BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P49189 (494 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 6QAO-A nrPDB 1022 0.0 1BPW-A nrPDB 747 0.0 4CAZ-A nrPDB 519 e-147 3R31-A nrPDB 481 e-136 5GT6-A nrPDB 379 e-105 5L13-A nrPDB 378 e-105 4O6R-A nrPDB 373 e-103 1AG8-A nrPDB 372 e-103 4PZ2-A nrPDB 361 e-100 4V3F-A nrPDB 358 2e-99 3RHO-A nrPDB 357 6e-99 4GO4-A nrPDB 353 8e-98 5KLK-A nrPDB 351 4e-97 5AC2-A nrPDB 351 5e-97 4X2Q-A nrPDB 351 5e-97 5AC0-A nrPDB 349 2e-96 2D4E-A nrPDB 348 2e-96 4PXL-B nrPDB 348 4e-96 3IWK-A nrPDB 347 7e-96 1O9J-A nrPDB 341 4e-94 4MPY-A nrPDB 340 7e-94 4I8Q-A nrPDB 338 4e-93 3IWJ-A nrPDB 335 3e-92 4U3W-A nrPDB 332 3e-91 5FHZ-A nrPDB 331 6e-91 4QYJ-A nrPDB 326 1e-89 4I8P-A nrPDB 322 2e-88 3U4J-A nrPDB 307 7e-84 3JZ4-A nrPDB 304 5e-83 4O5H-A nrPDB 303 1e-82 3TY7-A nrPDB 293 1e-79 1WNB-A nrPDB 291 3e-79 6C43-A nrPDB 287 6e-78 4V6H-A nrPDB 285 3e-77 5IUV-A nrPDB 284 6e-77 6MVR-A nrPDB 284 7e-77 6B4R-B nrPDB 282 2e-76 4LIH-A nrPDB 282 2e-76 4F3X-A nrPDB 281 4e-76 2HG2-A nrPDB 281 4e-76 3B4W-A nrPDB 278 4e-75 4YWE-A nrPDB 274 6e-74 3EK1-A nrPDB 270 1e-72 4JZ6-A nrPDB 267 6e-72 5J77-A nrPDB 266 1e-71 3K2W-A nrPDB 266 2e-71 5EUY-A nrPDB 255 3e-68 5VBF-A nrPDB 253 9e-68 2W8P-A nrPDB 249 1e-66 5X5U-A nrPDB 246 2e-65 3RHD-A nrPDB 243 2e-64 3EFV-A nrPDB 241 4e-64 1T90-A nrPDB 241 7e-64 3R64-A nrPDB 241 8e-64 3RH9-A nrPDB 235 4e-62 2QE0-A nrPDB 234 8e-62 3I44-A nrPDB 231 8e-61 3QAN-A nrPDB 230 1e-60 3VZ3-A nrPDB 227 9e-60 3RJL-A nrPDB 224 5e-59 6FK3-A nrPDB 223 2e-58 4DNG-A nrPDB 221 5e-58 4ZZ7-A nrPDB 219 2e-57 3VZ0-A nrPDB 219 3e-57 3PRL-A nrPDB 218 5e-57 5KF0-A nrPDB 216 2e-56 3ROS-A nrPDB 216 2e-56 5JRY-A nrPDB 214 9e-56 5TJR-A nrPDB 213 1e-55 4E4G-A nrPDB 213 2e-55 2J5N-A nrPDB 209 2e-54 2JG7-A nrPDB 207 9e-54 4OGD-A nrPDB 204 8e-53 5J6B-A nrPDB 201 6e-52 5N5S-A nrPDB 194 6e-50 4X0T-A nrPDB 188 5e-48 5U0M-A nrPDB 186 2e-47 4I3V-A nrPDB 186 3e-47 1UXV-A nrPDB 183 2e-46 5UR2-A nrPDB 183 2e-46 6DBB-A nrPDB 177 9e-45 4H7N-A nrPDB 174 7e-44 4PXN-A nrPDB 174 8e-44 4KNA-A nrPDB 167 9e-42 3SZA-A nrPDB 166 3e-41 1AD3-A nrPDB 162 3e-40 4LGZ-A nrPDB 155 5e-38 4QGK-A nrPDB 153 1e-37 3V9H-A nrPDB 152 3e-37 3JU8-A nrPDB 150 2e-36 5UCD-A nrPDB 142 5e-34 5NNO-A nrPDB 137 8e-33 4OE4-A nrPDB 116 2e-26 4IDS-A nrPDB 100 2e-21 2Y53-A nrPDB 96 4e-20 3V4C-A nrPDB 81 1e-15 5UJU-A nrPDB 64 1e-10 1EZ0-A nrPDB 60 2e-09 3MY7-A nrPDB 59 4e-09 6D97-A nrPDB 56 3e-08 5J7I-A nrPDB 52 6e-07 3K9D-A nrPDB 49 7e-06 5DBV-A nrPDB 33 0.30 5JFN-A nrPDB 33 0.38 5AA6-A nrPDB 32 0.64 4GDY-A nrPDB 30 3.2 4JBE-A nrPDB 29 5.2 1XMM-B nrPDB 28 9.2 1ORD-A nrPDB 28 9.3 >6QAO-A nrPDB Length = 508 Score = 1022 bits (2643), Expect = 0.0, Method: Compositional matrix adjust. Identities = 494/494 (100%), Positives = 494/494 (100%) Query: 1 MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA 60 MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA Sbjct: 15 MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA 74 Query: 61 AFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYY 120 AFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYY Sbjct: 75 AFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYY 134 Query: 121 AGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFK 180 AGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFK Sbjct: 135 AGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFK 194 Query: 181 PSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKI 240 PSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKI Sbjct: 195 PSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKI 254 Query: 241 MEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEI 300 MEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEI Sbjct: 255 MEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEI 314 Query: 301 LDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY 360 LDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY Sbjct: 315 LDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY 374 Query: 361 VPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA 420 VPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA Sbjct: 375 VPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA 434 Query: 421 AGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQL 480 AGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQL Sbjct: 435 AGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQL 494 Query: 481 KTVCVEMGDVESAF 494 KTVCVEMGDVESAF Sbjct: 495 KTVCVEMGDVESAF 508 >1BPW-A nrPDB Length = 503 Score = 747 bits (1928), Expect = 0.0, Method: Compositional matrix adjust. Identities = 348/493 (70%), Positives = 416/493 (84%) Query: 2 STGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAA 61 STG+ VV+ LNY GG R++ D + TE FEPATGRV+ G +EV+ AVQ+A+AA Sbjct: 11 STGSVVVTDDLNYWGGRRIKSKDGATTEPVFEPATGRVLCQMVPCGAEEVDQAVQSAQAA 70 Query: 62 FKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYA 121 + WS+ +G+ER R++LEAARIIRER D IA +E INNGK+I EA DID +WQC+EYYA Sbjct: 71 YLKWSKMAGIERSRVMLEAARIIRERRDNIAKLEVINNGKTITEAEYDIDAAWQCIEYYA 130 Query: 122 GLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKP 181 GLA +++G+HIQLPGG+F YTRREPLGVC GI AWNYPF IA+WK APALACGNA+VFKP Sbjct: 131 GLAPTLSGQHIQLPGGAFAYTRREPLGVCAGILAWNYPFMIAAWKCAPALACGNAVVFKP 190 Query: 182 SPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIM 241 SP TPV+ ++LAEI+ EAGVP GL NVVQGGA TG LC HP+VAKVSFTGSVPTG K+M Sbjct: 191 SPMTPVTGVILAEIFHEAGVPVGLVNVVQGGAETGSLLCHHPNVAKVSFTGSVPTGKKVM 250 Query: 242 EMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEIL 301 EMSAK +K VTLELGGKSPL+IF DC++ NAV+GALMANFLTQGQVC NGTRVFVQ+EI+ Sbjct: 251 EMSAKTVKHVTLELGGKSPLLIFKDCELENAVRGALMANFLTQGQVCTNGTRVFVQREIM 310 Query: 302 DKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYV 361 +F EEVVK+T+ I +GDPLL +TRMG LI++P L++VLGFV AK++GA+VLCGG+ Sbjct: 311 PQFLEEVVKRTKAIVVGDPLLTETRMGGLISKPQLDKVLGFVAQAKKEGARVLCGGEPLT 370 Query: 362 PEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAA 421 P DPKLK+GY+M PCVL NCRDDMTCVKEEIFGPVMS+L FDTE EVL+RAN+TTFGLA+ Sbjct: 371 PSDPKLKNGYFMSPCVLDNCRDDMTCVKEEIFGPVMSVLPFDTEEEVLQRANNTTFGLAS 430 Query: 422 GVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLK 481 GVFTRDI RAHRV A L+AGTC+IN Y++SPVE+PFGGYK SGFGRENG+ T++YYSQLK Sbjct: 431 GVFTRDISRAHRVAANLEAGTCYINTYSISPVEVPFGGYKMSGFGRENGQATVDYYSQLK 490 Query: 482 TVCVEMGDVESAF 494 TV VEMGDV+S F Sbjct: 491 TVIVEMGDVDSLF 503 >4CAZ-A nrPDB Length = 490 Score = 519 bits (1336), Expect = e-147, Method: Compositional matrix adjust. Identities = 256/484 (52%), Positives = 334/484 (69%), Gaps = 6/484 (1%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMER 73 Y GG VE A + T + PA G V+A + ++V AVQ+A K+W+ + M+R Sbjct: 10 YIGGRYVE-ASSGATFETINPANGEVLAKVQRASREDVERAVQSAVEGQKVWAAMTAMQR 68 Query: 74 CRILLEAARIIREREDEIATMECINNGKSIFEAR-LDIDISWQCLEYYAGLAASMAGEHI 132 RIL A I+RER DE+A +E ++ GK + E R +DI LEYYAGL ++ GE I Sbjct: 69 SRILRRAVDILRERNDELAALETLDTGKPLAETRSVDIVTGADVLEYYAGLVPAIEGEQI 128 Query: 133 QLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLL 192 L SF YTRREPLGV GIGAWNYP QIA WKSAPALA GNAM+FKPS TP++AL L Sbjct: 129 PLRETSFVYTRREPLGVVAGIGAWNYPVQIALWKSAPALAAGNAMIFKPSEVTPLTALKL 188 Query: 193 AEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIM-EMSAKGIKP 250 AEIY+EAGVP G+FNV+ G G GQ+L +HP + K+SFTG TG K+M S+ +K Sbjct: 189 AEIYTEAGVPDGVFNVLTGSGREVGQWLTEHPLIEKISFTGGTSTGKKVMASASSSSLKE 248 Query: 251 VTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVK 310 VT+ELGGKSPLIIF D D++ A A+MANF + GQVC NGTRVF+ + +F +V++ Sbjct: 249 VTMELGGKSPLIIFPDADLDRAADIAVMANFFSSGQVCTNGTRVFIHRSQQARFEAKVLE 308 Query: 311 QTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDG 370 + QRI++GDP E+T GPL++ PH+E VLG+++ K Q A++LCGG+ D G Sbjct: 309 RVQRIRLGDPQDENTNFGPLVSFPHMESVLGYIESGKAQKARLLCGGERVT--DGAFGKG 366 Query: 371 YYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQR 430 Y+ P V T+CRDDMT V+EEIFGPVMSIL +D E E + RANDT +GLAAGV T+D+ R Sbjct: 367 AYVAPTVFTDCRDDMTIVREEIFGPVMSILVYDDEDEAIRRANDTEYGLAAGVVTQDLAR 426 Query: 431 AHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDV 490 AHR + L+AG C+IN + SP E+P GGYK+SG GRENG T+ +Y+++K+V VE+GD Sbjct: 427 AHRAIHRLEAGICWINTWGESPAEMPVGGYKQSGVGRENGLTTLAHYTRIKSVQVELGDY 486 Query: 491 ESAF 494 S F Sbjct: 487 ASVF 490 >3R31-A nrPDB Length = 517 Score = 481 bits (1239), Expect = e-136, Method: Compositional matrix adjust. Identities = 253/498 (50%), Positives = 332/498 (66%), Gaps = 9/498 (1%) Query: 1 MSTGTFVVSQPL--NYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNA 58 M+ T + +QP ++ G VE + E F PATG +IA + V A+ +A Sbjct: 3 MTIATPLKAQPKASHFIDGDYVEDNTGTPFESIF-PATGEMIAKLHAATPAIVERAIASA 61 Query: 59 KAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARL-DIDISWQCL 117 K A K W+ S M R RIL AA I+RER D ++T+E ++ GK I E + D Sbjct: 62 KRAQKEWAAMSPMARGRILKRAADIMRERNDALSTLETLDTGKPIQETIVADPTSGADAF 121 Query: 118 EYYAGLAAS-MAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNA 176 E++ G+A S + G++I L GG F YT+R PLGVCVGIGAWNYP QIA WK+APAL GNA Sbjct: 122 EFFGGIAPSALNGDYIPL-GGDFAYTKRVPLGVCVGIGAWNYPQQIACWKAAPALVAGNA 180 Query: 177 MVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPT 236 MVFKPS TP+ AL +AEI EAG+P GLFNV+QG TG L HPDVAKVS TGSVPT Sbjct: 181 MVFKPSENTPLGALKIAEILIEAGLPKGLFNVIQGDRDTGPLLVNHPDVAKVSLTGSVPT 240 Query: 237 GMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFV 296 G K+ +A +K VT+ELGGKSP+I+F D D+ +AV GA++ NF + GQVC NGTRVFV Sbjct: 241 GRKVAAAAAGHLKHVTMELGGKSPMIVFDDADIESAVGGAMLGNFYSSGQVCSNGTRVFV 300 Query: 297 QKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCG 356 QK+ +F E + ++T+ + +GDPL T +GPL+++ E+VL +++ K +GA ++ G Sbjct: 301 QKKAKARFLENLKRRTEAMILGDPLDYATHLGPLVSKAQQEKVLSYIEKGKAEGATLITG 360 Query: 357 GDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTT 416 G I + +G Y++P V + DDMT +EEIFGPVM +L FD E EVL RAN T Sbjct: 361 GGI---PNNVAGEGAYVQPTVFADVTDDMTIAREEIFGPVMCVLDFDDEDEVLARANATE 417 Query: 417 FGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEY 476 FGLA GVFT D+ RAHRVV L+AGT +IN YN+ PVE+PFGG K+SGFGREN +E+ Sbjct: 418 FGLAGGVFTADLARAHRVVDGLEAGTLWINTYNLCPVEIPFGGSKQSGFGRENSAAALEH 477 Query: 477 YSQLKTVCVEMGDVESAF 494 YS+LKTV V G V++ + Sbjct: 478 YSELKTVYVSTGKVDAPY 495 >5GT6-A nrPDB Length = 508 Score = 379 bits (972), Expect = e-105, Method: Compositional matrix adjust. Identities = 193/465 (41%), Positives = 291/465 (62%), Gaps = 12/465 (2%) Query: 28 TEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI--WSQKSGMERCRILLEAARIIR 85 T + + PAT V+A + E++++ AV+ A++AF+ W++ + ER ++ + A +I Sbjct: 50 TFETYNPATEDVLAVVCEAQEEDIDAAVKAARSAFESGPWAEMTTAERAHLIYKLADLIE 109 Query: 86 EREDEIATMECINNGKSIFEARLDIDISW--QCLEYYAGLAASMAGEHIQLPGGSFGYTR 143 E +E+A +E ++NGK ++ LD DIS + YYAG + G+ I + YTR Sbjct: 110 EHREELAQLEALDNGKP-YQVALDDDISATVENYRYYAGWTTKIIGQTIPISKDYLNYTR 168 Query: 144 REPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPP 203 EP+GV I WN+P ++SWK ALA G +V KP+ TP+S L A+++ EAG P Sbjct: 169 HEPVGVVGQIIPWNFPLVMSSWKMGAALATGCTIVLKPAEQTPLSLLYAAKLFKEAGFPN 228 Query: 204 GLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLI 262 G+ N V G G G + H D+ KV+FTGS TG IM SA+ IK VTLELGGKSP I Sbjct: 229 GVVNFVPGFGPEAGAAIVNHHDIDKVAFTGSTVTGKYIMRQSAEMIKHVTLELGGKSPNI 288 Query: 263 IFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLL 322 I D D+ A+ GA GQ C G+RVFV ++ + + +VK +K+G + Sbjct: 289 ILEDADLEEAINGAFQGIMYNHGQNCSAGSRVFVHRKHYETVVDALVKMANNVKLGAGME 348 Query: 323 EDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCR 382 ++T MGPL+++ ERVL +++ K++GA V GG+ L+ GY+++P V T+ Sbjct: 349 KETEMGPLVSKKQQERVLNYIEQGKKEGATVAAGGE------RALEKGYFVKPTVFTDVT 402 Query: 383 DDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGT 442 DDMT VKEEIFGPV+ +L FD+ EV+ERAN++++GLAAGV+T++I+ H+V +L+AGT Sbjct: 403 DDMTIVKEEIFGPVVVVLPFDSTEEVIERANNSSYGLAAGVWTQNIKTGHQVANKLKAGT 462 Query: 443 CFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 487 +IN+YN+ PFGGYK+SG GRE G ++ Y+++K+V V + Sbjct: 463 VWINDYNLENAAAPFGGYKQSGIGRELGSYALDNYTEVKSVWVNI 507 >5L13-A nrPDB Length = 517 Score = 378 bits (971), Expect = e-105, Method: Compositional matrix adjust. Identities = 198/461 (42%), Positives = 287/461 (62%), Gaps = 14/461 (3%) Query: 34 PATGRVIATFTCSGEKEVNLAVQNAKAAFKI---WSQKSGMERCRILLEAARIIREREDE 90 P+TG VI +++V+ AV+ A+AAF++ W + R R+L A +I Sbjct: 59 PSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTY 118 Query: 91 IATMECINNGKS-IFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGV 149 +A +E ++NGK + +D+D+ +CL YYAG A G+ I + G F YTR EP+GV Sbjct: 119 LAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGV 178 Query: 150 CVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVV 209 C I WN+P + +WK PALA GN +V K + TP++AL +A + EAG PPG+ N+V Sbjct: 179 CGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIV 238 Query: 210 QG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSA--KGIKPVTLELGGKSPLIIFSD 266 G G G + H DV KV+FTGS G ++++++A +K VTLELGGKSP II SD Sbjct: 239 PGFGPTAGAAIASHEDVDKVAFTGSTEIG-RVIQVAAGSSNLKRVTLELGGKSPNIIMSD 297 Query: 267 CDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTR 326 DM+ AV+ A A F QGQ CC G+R FVQ++I D+F E V + + +G+P T Sbjct: 298 ADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTE 357 Query: 327 MGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMT 386 GP ++ +++LG++ K++GAK+LCGG I GY+++P V + +D MT Sbjct: 358 QGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADR------GYFIQPTVFGDVQDGMT 411 Query: 387 CVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFIN 446 KEEIFGPVM IL F T EV+ RAN++T+GLAA VFT+D+ +A+ + LQAGT ++N Sbjct: 412 IAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVN 471 Query: 447 NYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 487 Y+V + PFGGYK SG GRE G ++ Y+++KTV V++ Sbjct: 472 CYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKV 512 >4O6R-A nrPDB Length = 496 Score = 373 bits (958), Expect = e-103, Method: Compositional matrix adjust. Identities = 193/471 (40%), Positives = 272/471 (57%), Gaps = 5/471 (1%) Query: 27 GTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIRE 86 GT P G VI + +V+LAV A AF WS ER R+LL A I Sbjct: 26 GTIDVLNPHDGSVITKIAAATAADVDLAVDAATRAFPAWSAMPAAERGRLLLRLADAIEA 85 Query: 87 REDEIATMECINNGKSIFEAR-LDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRRE 145 + +A +E ++ G I ++R LD+ + C Y+ G+A + G I + G Y +R Sbjct: 86 NTEALAQLESLDTGHPIRDSRALDVPRTAACFRYFGGMADKLQGSVIPVDTGFLNYVQRA 145 Query: 146 PLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGL 205 P+GV I WN+P SWK PALA GN +V KPS TP+S L + E+ +E G P G+ Sbjct: 146 PIGVVGQIVPWNFPLMFTSWKMGPALAAGNTVVLKPSEITPLSTLRIVELMAEVGFPAGV 205 Query: 206 FNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIF 264 N+V G G GQ L +HP V K++FTGS TG +I+E S +K V LELGGK I+F Sbjct: 206 VNIVPGYGHTAGQRLAEHPGVGKIAFTGSTATGRRIVEASQGNLKRVQLELGGKGANIVF 265 Query: 265 SDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLED 324 D +++ A+ GA A F QGQ C G+R+ + + I D F E V I+IG+PL + Sbjct: 266 DDANLDAAINGAAWAIFHNQGQACIAGSRLVLHERIADAFLERFVALASSIRIGNPLDPN 325 Query: 325 TRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDD 384 T MGPL ++ HL+RVL +V VA+EQG +VL GG P+DP L +GYY+RP ++ Sbjct: 326 TEMGPLTSKQHLDRVLSYVDVAREQGGRVLTGGS--APQDPALANGYYVRPTIVEAKHAT 383 Query: 385 MTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCF 444 +EE+FGP +++L F ++ E L AN T +GL +G++T D+ RAHR+ A + AG C+ Sbjct: 384 DRVAQEEVFGPFVTVLRFGSDDEALAIANATEYGLGSGLWTNDLSRAHRMAARIDAGMCW 443 Query: 445 INNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM-GDVESAF 494 IN Y PFGG KSG+GRE G + Y++ ++V V + G+V F Sbjct: 444 INCYKRVNPGSPFGGVGKSGYGREMGFEAMHDYTEARSVWVNVDGNVPPHF 494 >1AG8-A nrPDB Length = 499 Score = 372 bits (954), Expect = e-103, Method: Compositional matrix adjust. Identities = 198/460 (43%), Positives = 279/460 (60%), Gaps = 12/460 (2%) Query: 34 PATGRVIATFTCSGEKEVNLAVQNAKAAFKI---WSQKSGMERCRILLEAARIIREREDE 90 P+TG VI + +V+ AV+ A+AAF++ W + ER R+L A +I Sbjct: 41 PSTGDVICHVAEGDKADVDRAVKAARAAFQLGSPWRRMDASERGRLLNRLADLIERDRTY 100 Query: 91 IATMECINNGKS-IFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGV 149 +A +E ++NGK I +D+D+ +CL YYAG A G+ I + G F YTR EP+GV Sbjct: 101 LAALETLDNGKPYIISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDYFSYTRHEPVGV 160 Query: 150 CVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVV 209 C I WN+P + +WK PALA GN +V K + TP++AL +A + EAG PPG+ NV+ Sbjct: 161 CGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNVI 220 Query: 210 QG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK-GIKPVTLELGGKSPLIIFSDC 267 G G G + H DV KV+FTGS G I + K +K VTLE+GGKSP II SD Sbjct: 221 PGFGPTAGAAIASHEDVDKVAFTGSTEVGHLIQVAAGKSNLKRVTLEIGGKSPNIIMSDA 280 Query: 268 DMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRM 327 DM+ AV+ A A F QGQ CC G+R FVQ++I +F E V + + +G+P T Sbjct: 281 DMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYAEFVERSVARAKSRVVGNPFDSRTEQ 340 Query: 328 GPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTC 387 GP ++ ++VLG++K KE+G K+LCGG GY+++P V + +D MT Sbjct: 341 GPQVDETQFKKVLGYIKSGKEEGLKLLCGGGAAADR------GYFIQPTVFGDLQDGMTI 394 Query: 388 VKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN 447 KEEIFGPVM IL F + EV+ RAN++ +GLAA VFT+D+ +A+ + LQAGT ++N Sbjct: 395 AKEEIFGPVMQILKFKSMEEVVGRANNSKYGLAAAVFTKDLDKANYLSQALQAGTVWVNC 454 Query: 448 YNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 487 Y+V + PFGGYK SG GRE G ++ Y+++KTV V + Sbjct: 455 YDVFGAQSPFGGYKLSGSGRELGEYGLQAYTEVKTVTVRV 494 >4PZ2-A nrPDB Length = 534 Score = 361 bits (926), Expect = e-100, Method: Compositional matrix adjust. Identities = 199/462 (43%), Positives = 284/462 (61%), Gaps = 12/462 (2%) Query: 33 EPATGRVIATFTCSGEKEVNLAVQNAKAAFKI--WSQKSGMERCRILLEAARIIREREDE 90 +P TG VIA+ + +++V+LAV+ A+AAF W + SG ER RI+ A ++ E E Sbjct: 72 DPRTGGVIASVAEADKEDVDLAVRAARAAFDHGEWPRMSGSERGRIMARLADLVEEHAGE 131 Query: 91 IATMECINNGKSIFEAR-LDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGV 149 +A +E ++ GK R +D+ + L Y+AG A + GE +++PG G+T REPLGV Sbjct: 132 LAALESLDAGKHPAVTRAVDVGNAAGSLRYFAGAADKIHGETLKMPGQFQGHTLREPLGV 191 Query: 150 CVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVV 209 I WN+P + + K APALA G A+V KP+ TP+SAL LA++ +AGVP G+ NVV Sbjct: 192 AGVIIPWNFPSTMFAVKVAPALAAGCALVVKPAEQTPLSALYLAQLAKQAGVPDGVINVV 251 Query: 210 QG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKG-IKPVTLELGGKSPLIIFSDC 267 G G G L H DV VSFTGS G IM+ SA+ +KPV LELGGKSPLI+F D Sbjct: 252 PGFGPTAGAALASHMDVDMVSFTGSTEVGRLIMKASAESNLKPVYLELGGKSPLIVFDDA 311 Query: 268 DMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTR- 326 D++ AV+ A+ A+F +G+ C +RV+VQ+ + D+F E + ++ + +GDP D R Sbjct: 312 DLDMAVELAVGASFFNKGEACVAASRVYVQERVYDRFEERLAERMRSWVVGDPF-SDPRA 370 Query: 327 -MGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDM 385 GP +++ ERVL ++ K +GA +L GG PE GYY+ P V TN ++DM Sbjct: 371 DQGPQVDKAQYERVLSYIDHGKREGATLLTGGRPCAPE----GKGYYIEPTVFTNVKEDM 426 Query: 386 TCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFI 445 KEEIFGPVM ++ F T E + RANDT +GL AGV TRD+ A+RVV ++AG ++ Sbjct: 427 IIAKEEIFGPVMCLMKFKTVEEAIARANDTRYGLGAGVVTRDLDVANRVVRSVRAGVVWV 486 Query: 446 NNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 487 N Y + PFGG K SGFG++ G ++ Y +K+V + Sbjct: 487 NCYFAMGSDCPFGGRKMSGFGKDEGMHALDKYLAVKSVVTPL 528 >4V3F-A nrPDB Length = 497 Score = 358 bits (920), Expect = 2e-99, Method: Compositional matrix adjust. Identities = 188/463 (40%), Positives = 275/463 (59%), Gaps = 11/463 (2%) Query: 34 PATGRVIATFTCSGEKEVNLAVQNAKAAFKI--WSQKSGMERCRILLEAARIIREREDEI 91 P+T +I + ++V +AV A+ AF+ WS SG R L A I E++D Sbjct: 30 PSTEEIIGDIPAATAEDVEVAVVAARRAFRRNNWSATSGAHRATYLRAIAAKITEKKDHF 89 Query: 92 ATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEH---IQLPGGSF-GYTRREPL 147 +E I++GK EA LDID C EY+AG A ++ G+ + LP F + R+PL Sbjct: 90 VKLETIDSGKPFDEAVLDIDDVASCFEYFAGQAEALDGKQKAPVTLPMERFKSHVLRQPL 149 Query: 148 GVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFN 207 GV I WNYP +A+WK APALA G V KPS V+ L E+ +E G+PPG+ N Sbjct: 150 GVVGLISPWNYPLLMATWKIAPALAAGCTAVLKPSELASVTCLEFGEVCNEVGLPPGVLN 209 Query: 208 VVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSD 266 ++ G G G L HPDV K++FTGS TG K+M +A+ +KPVTLELGGKSP+++F D Sbjct: 210 ILTGLGPDAGAPLVSHPDVDKIAFTGSSATGSKVMASAAQLVKPVTLELGGKSPIVVFED 269 Query: 267 CDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTR 326 D++ V+ + F T GQ+C +R+ V + I +F +++VK T+ IKI DP E R Sbjct: 270 VDIDKVVEWTIFGCFWTNGQICSATSRLLVHESIAAEFVDKLVKWTKNIKISDPFEEGCR 329 Query: 327 MGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMT 386 +GP+I++ ++++ F+ AK +GA +L GG PE LK GYY+ P ++T+ M Sbjct: 330 LGPVISKGQYDKIMKFISTAKSEGATILYGGS--RPE--HLKKGYYIEPTIVTDISTSMQ 385 Query: 387 CVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFIN 446 KEE+FGPV+ + +F +E E + ANDT +GLAA VF+ D++R R+ L+ G ++N Sbjct: 386 IWKEEVFGPVLCVKTFSSEDEAIALANDTEYGLAAAVFSNDLERCERITKALEVGAVWVN 445 Query: 447 NYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGD 489 V+ P+GG K+SGFGRE G I+ Y +K V ++ D Sbjct: 446 CSQPCFVQAPWGGIKRSGFGRELGEWGIQNYLNIKQVTQDISD 488 >3RHO-A nrPDB Length = 517 Score = 357 bits (917), Expect = 6e-99, Method: Compositional matrix adjust. Identities = 195/485 (40%), Positives = 295/485 (60%), Gaps = 20/485 (4%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFK--IWSQKSGM 71 + GG V+ A+ S T P G VI + + +V+ AV AK AF+ +W + + Sbjct: 40 FIGGEFVD-AEGSKTYNTINPTDGSVICQVSLAQVSDVDKAVAAAKEAFENGLWGKINAR 98 Query: 72 ERCRILLEAARIIREREDEIATMECINNGKSIFEA-RLDIDISWQCLEYYAGLAASMAGE 130 +R R+L A ++ + ++E+AT+E ++ G A + + +S Q Y+AG + G Sbjct: 99 DRGRLLYRLADVMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGA 158 Query: 131 HIQL----PGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTP 186 I + P + T++EP+GVC + WNYP + SWK+A LA GN +V KP+ TP Sbjct: 159 TIPINQARPNRNLTLTKKEPVGVCGIVIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTP 218 Query: 187 VSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSA 245 ++AL AE+ +AG+P G+ N++ G G+ GQ L HPDV K+ FTGS G IM+ A Sbjct: 219 LTALKFAELTLKAGIPKGVVNILPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCA 278 Query: 246 -KGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKF 304 +K V+L+LGGKSPLIIF+DCD+N AV+ + + F +G+ C R+FV++ I ++F Sbjct: 279 LSNVKKVSLQLGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEESIHNQF 338 Query: 305 TEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPED 364 ++VV++ +++KIG+PL DT GP + HL +++ + + ++GA ++CGG+ VP Sbjct: 339 VQKVVEEVEKMKIGNPLERDTNHGPQNHEAHLRKLVEYCQRGVKEGATLVCGGN-QVP-- 395 Query: 365 PKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSF---DTEAEVLERANDTTFGLAA 421 + G++ +P V T+ D M KEE FGP+M I F D +A VL RAN T FGLA+ Sbjct: 396 ---RPGFFFQPTVFTDVEDHMYIAKEESFGPIMIISRFADGDVDA-VLSRANATEFGLAS 451 Query: 422 GVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLK 481 GVFTRDI +A V +LQAGT FIN YN + V PFGG+K+SGFG++ G + Y ++K Sbjct: 452 GVFTRDINKALYVSDKLQAGTVFINTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRIK 511 Query: 482 TVCVE 486 TV E Sbjct: 512 TVTFE 516 >4GO4-A nrPDB Length = 495 Score = 353 bits (907), Expect = 8e-98, Method: Compositional matrix adjust. Identities = 192/472 (40%), Positives = 278/472 (58%), Gaps = 7/472 (1%) Query: 19 RVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILL 78 R A A GT P G +I + +V+LAV AK AF WS ER R+LL Sbjct: 10 RFVDAVAGGTIDVVSPHDGSLITRIAAAEAADVDLAVAAAKRAFPAWSALGAAERGRLLL 69 Query: 79 EAARIIREREDEIATMECINNGKSIFEAR-LDIDISWQCLEYYAGLAASMAGEHIQLPGG 137 + A I E +E+A +E +N G I ++R LD+ + C Y+ G+A + G I + G Sbjct: 70 KLADRIEECSEELAQLESLNTGHPIRDSRGLDVPRTAACFRYFGGMADKIEGSVIPVDAG 129 Query: 138 SFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYS 197 Y +R+P+GV I WN+P SWK PALA GN +V KPS TP+S L + E+ + Sbjct: 130 FLNYVQRKPIGVVAQIVPWNFPLMFTSWKMGPALAAGNTIVIKPSEITPLSTLRIVELMT 189 Query: 198 EAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELG 256 E G P G+ NVV G G GQ L +H DV K++FTGS TG +I+E S +K + LELG Sbjct: 190 EVGFPKGVVNVVPGYGHTAGQALAEHLDVGKIAFTGSTATGRRIVEASKSNLKRIQLELG 249 Query: 257 GKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIK 316 GK I+F D ++ AV GA A F QGQ C G+R+ + K+I D+F E + + I+ Sbjct: 250 GKGANIVFEDANIEAAVNGAAWAIFHNQGQACIAGSRLILHKDIADQFLERFIALAKSIR 309 Query: 317 IGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPC 376 +GDP+ +T MGPL + +RVL ++ +A EQG KVL GG P+D L +G+Y+ P Sbjct: 310 LGDPMDPETEMGPLTSALRRDRVLSYIDIAIEQGGKVLAGGK--APDDKALANGFYVEPT 367 Query: 377 VLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVA 436 V+ D C +EE+FGP ++++ F ++ E L AN+T +GL +G++T+++ RAH++ Sbjct: 368 VVEAKPQDRVC-QEEVFGPFVTVVRFSSDEEALAIANNTEYGLGSGLWTQNLARAHKMAH 426 Query: 437 ELQAGTCFINNYN-VSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 487 + AG C+IN Y VSP PFGG +SG+GRE G I Y++ ++V V + Sbjct: 427 AIHAGMCWINCYKRVSPGS-PFGGVGQSGYGREMGFEAIHDYTEARSVWVNV 477 >5KLK-A nrPDB Length = 520 Score = 351 bits (901), Expect = 4e-97, Method: Compositional matrix adjust. Identities = 185/491 (37%), Positives = 285/491 (58%), Gaps = 20/491 (4%) Query: 9 SQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFK-IWSQ 67 SQ LNY G V A + P G++I+ + K+VN AV A+ A K W + Sbjct: 38 SQLLNYIDGNFVTSASSFAN---INPVNGKLISDVFEADAKQVNEAVVAAQNALKGPWGK 94 Query: 68 KSGMERCRILLEAARIIREREDEIATMECINNGKSIFEAR-LDIDISWQCLEYYAGLAAS 126 S +R ++ + A I+ R +E E + G+ + +AR LDI + +A LA + Sbjct: 95 LSVQDRAALIHKIADGIQARFEEFVAAEVADTGRPVHQARTLDIPRAIANFRTFADLAKT 154 Query: 127 MAGEHIQLP----GGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPS 182 + ++ G+ YT R+PLGV I W+ P + +WK APALACGN +V KPS Sbjct: 155 SHTDLFEMSTSDGSGALNYTVRKPLGVIGVISPWDLPLLLFTWKVAPALACGNTVVAKPS 214 Query: 183 PFTPVSALLLAEIYSEAGVPPGLFNVVQG--GAATGQFLCQHPDVAKVSFTGSVPTGMKI 240 +P SA LLAE+ +AGVPPG+FN++ G + G+FL QHP ++ ++FTG TG I Sbjct: 215 EESPSSATLLAEVMHDAGVPPGVFNLIHGFGKDSAGEFLTQHPGISALTFTGESKTGSTI 274 Query: 241 MEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEI 300 M+ A G+K V+ ELGGK+ ++F+D D++ A++G L ++F GQVC RV+V + I Sbjct: 275 MKAVADGVKEVSFELGGKNAAVVFADADLDAAIEGVLRSSFTNSGQVCLCSERVYVHRSI 334 Query: 301 LDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY 360 D+F + + +R+ +G P + MGPLI+ H ++VL + ++A ++GA V+ GG + Sbjct: 335 FDEFVSGLKVEAERLVVGYPDQDGVNMGPLISHGHRDKVLSYYRLAVDEGATVVTGGGV- 393 Query: 361 VPEDPKLKD----GYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTT 416 PK D G Y++P + T D CV EEIFGPV I FD E EV+ R ND+ Sbjct: 394 ----PKFNDERDQGAYVQPTIWTGLSDKARCVTEEIFGPVCHISPFDDEDEVINRVNDSN 449 Query: 417 FGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEY 476 +GLA ++T ++ RAHRV ++ G ++N + + + PFGG K SG GRE GR ++++ Sbjct: 450 YGLACAIWTTNLSRAHRVSRQIHVGLVWVNTWYLRDLRTPFGGVKLSGLGREGGRFSMDF 509 Query: 477 YSQLKTVCVEM 487 YS + +C+++ Sbjct: 510 YSDIANICIKI 520 >5AC2-A nrPDB Length = 501 Score = 351 bits (900), Expect = 5e-97, Method: Compositional matrix adjust. Identities = 190/467 (40%), Positives = 276/467 (59%), Gaps = 12/467 (2%) Query: 32 FEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI---WSQKSGMERCRILLEAARIIRERE 88 F PAT + +++V+ AV+ A+ AF+I W ER R+L + A +I Sbjct: 41 FNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDR 100 Query: 89 DEIATMECINNGKSIFEARL-DIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPL 147 +ATME +N GK A L D+ + L Y AG A + G I + G F YTR EP+ Sbjct: 101 LLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPI 160 Query: 148 GVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFN 207 GVC I WN+P + WK PAL+CGN +V KP+ TP++AL +A + EAG PPG+ N Sbjct: 161 GVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVN 220 Query: 208 VVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK-GIKPVTLELGGKSPLIIFS 265 +V G G G + H D+ KV+FTGS G I E + K +K VTLELGGKSP I+ + Sbjct: 221 IVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLA 280 Query: 266 DCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDT 325 D D++NAV+ A F QGQ C +R+FV++ I D+F V++ ++ +G+PL Sbjct: 281 DADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGV 340 Query: 326 RMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDM 385 GP I++ +++L ++ K++GAK+ CGG P GY+++P V +N D+M Sbjct: 341 TQGPQIDKEQYDKILDLIESGKKEGAKLECGGG------PWGNKGYFVQPTVFSNVTDEM 394 Query: 386 TCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFI 445 KEEIFGPV I+ F + +V++RAN+T +GL+AGVFT+DI +A + + LQAGT ++ Sbjct: 395 RIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWV 454 Query: 446 NNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDVES 492 N Y V + PFGG+K SG GRE G Y+++KTV V++ S Sbjct: 455 NCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKISQKNS 501 >4X2Q-A nrPDB Length = 504 Score = 351 bits (900), Expect = 5e-97, Method: Compositional matrix adjust. Identities = 187/462 (40%), Positives = 270/462 (58%), Gaps = 12/462 (2%) Query: 32 FEPATGRVIATFTCSGEKEVNLAVQNAKAAFK---IWSQKSGMERCRILLEAARIIRERE 88 + PATG + + + +++ AVQ A+ AF +W + ER R+L + A ++ Sbjct: 44 YNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDR 103 Query: 89 DEIATMECINNGKSIFEA-RLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPL 147 +ATME +N GK +A +D+ + YYAG A + G I + G F +TR EP+ Sbjct: 104 AVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPI 163 Query: 148 GVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFN 207 GVC I WN+P + +WK APAL CGN +V KP+ TP+SAL + + EAG PPG+ N Sbjct: 164 GVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVIN 223 Query: 208 VVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK-GIKPVTLELGGKSPLIIFS 265 ++ G G G + H + K++FTGS G I E + + +K VTLELGGKSP IIF+ Sbjct: 224 ILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFA 283 Query: 266 DCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDT 325 D D++ AV+ A F QGQ C G+R+FV++ I ++F V++ +R +G P T Sbjct: 284 DADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTT 343 Query: 326 RMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDM 385 GP I++ ++L ++ +GAK+ CGG + G+++ P V +N DDM Sbjct: 344 EQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLG------RKGFFIEPTVFSNVTDDM 397 Query: 386 TCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFI 445 KEEIFGPV IL F T EV+ERAN++ FGL A VFT DI +A V + +QAGT +I Sbjct: 398 RIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWI 457 Query: 446 NNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 487 N YN + PFGG+K SG GRE G + YS++KTV V++ Sbjct: 458 NCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKI 499 >5AC0-A nrPDB Length = 501 Score = 349 bits (895), Expect = 2e-96, Method: Compositional matrix adjust. Identities = 189/467 (40%), Positives = 276/467 (59%), Gaps = 12/467 (2%) Query: 32 FEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI---WSQKSGMERCRILLEAARIIRERE 88 F PAT + +++V+ AV+ A+ AF+I W ER R+L + A +I Sbjct: 41 FNPATEEKLCEVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLNKLADLIERDR 100 Query: 89 DEIATMECINNGKSIFEARL-DIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPL 147 +ATME +N GK A L D+ + L Y AG A + G I + G F YTR EP+ Sbjct: 101 LLLATMEAMNGGKLFSNAYLMDLGGCIKTLRYCAGWADKIQGRTIPMDGNFFTYTRSEPV 160 Query: 148 GVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFN 207 GVC I WN+P + WK PAL+CGN +V KP+ TP++AL + + EAG PPG+ N Sbjct: 161 GVCGQIIPWNFPLLMFLWKIGPALSCGNTVVVKPAEQTPLTALHMGSLIKEAGFPPGVVN 220 Query: 208 VVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK-GIKPVTLELGGKSPLIIFS 265 +V G G G + H DV KV+FTGS G I E + K +K V+LELGGKSP I+F+ Sbjct: 221 IVPGYGPTAGAAISSHMDVDKVAFTGSTEVGKLIKEAAGKSNLKRVSLELGGKSPCIVFA 280 Query: 266 DCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDT 325 D D++NAV+ A F QGQ C +R+FV++ I D+F V++ ++ +G+PL Sbjct: 281 DADLDNAVEFAHQGVFYHQGQCCIAASRLFVEESIYDEFVRRSVERAKKYVLGNPLTPGV 340 Query: 326 RMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDM 385 GP I++ E++L ++ K++GAK+ CGG P GY+++P V ++ DDM Sbjct: 341 SQGPQIDKEQYEKILDLIESGKKEGAKLECGGG------PWGNKGYFIQPTVFSDVTDDM 394 Query: 386 TCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFI 445 KEEIFGPV I+ F + +V++RAN+T +GL+AG+FT DI +A V + LQ+GT ++ Sbjct: 395 RIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGIFTNDIDKAITVSSALQSGTVWV 454 Query: 446 NNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDVES 492 N Y+V + PFGG+K SG GRE G Y+++KTV +++ S Sbjct: 455 NCYSVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTIKISQKNS 501 >2D4E-A nrPDB Length = 515 Score = 348 bits (894), Expect = 2e-96, Method: Compositional matrix adjust. Identities = 183/472 (38%), Positives = 279/472 (59%), Gaps = 9/472 (1%) Query: 22 PADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAA 81 P+++ T + +PAT V+ GE+EV+ A + A AF+ WS+ ER R LL A Sbjct: 37 PSESGETFPSLDPATNEVLGVAARGGEREVDRAAKAAHEAFQRWSRTKAKERKRYLLRIA 96 Query: 82 RIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLA-ASMAGEHIQLPGGSFG 140 +I + DE+A MEC++ G+ + R + + + +YA A +M + Sbjct: 97 ELIEKHADELAVMECLDAGQVLRIVRAQVARAAENFAFYAEYAEHAMEDRTFPVDRDWLY 156 Query: 141 YTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAG 200 YT R P G I WN P +++W+ APALA GN +V KP+ ++P +A LAEI EA Sbjct: 157 YTVRVPAGPVGIITPWNAPLMLSTWRIAPALAFGNTVVLKPAEWSPFTATKLAEILKEAD 216 Query: 201 VPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKS 259 +PPG+FN+VQG G G L HP V ++ TG TG +M +A +K ++ ELGGKS Sbjct: 217 LPPGVFNLVQGFGEEAGAALVAHPLVPLLTLTGETETGKIVMRNAADHLKRLSPELGGKS 276 Query: 260 PLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGD 319 P ++F+D D+ A+ + F G+ C +R+ V+++I + F +VV++ + I++G Sbjct: 277 PALVFADADLERALDAVVFQIFSFNGERCTASSRLLVEEKIFEDFVGKVVERARAIRVGH 336 Query: 320 PLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGD----IYVPEDPKLKDGYYMRP 375 PL +T +GPLI+ HL+RVLG+V+ K +GA++L GG+ + ED L G Y+ P Sbjct: 337 PLDPETEVGPLIHPEHLQRVLGYVEAGKREGARLLVGGERAKTSFRGED--LSRGNYLLP 394 Query: 376 CVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVV 435 V + M +EEIFGPV+ + F E E L +ANDT +GLAA VFTRD++RAHR+ Sbjct: 395 TVFVG-ENHMKIAQEEIFGPVLVAIPFKDEEEALRKANDTKYGLAAYVFTRDLERAHRLA 453 Query: 436 AELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 487 EL+AG ++N++NV + PFGG K SG RE G +++Y+ LKT+ + + Sbjct: 454 LELEAGMVYLNSHNVRHLPTPFGGVKGSGDRREGGTYALDFYTDLKTIALPL 505 >4PXL-B nrPDB Length = 517 Score = 348 bits (892), Expect = 4e-96, Method: Compositional matrix adjust. Identities = 186/461 (40%), Positives = 279/461 (60%), Gaps = 13/461 (2%) Query: 33 EPATGRVIATFTCSGEKEVNLAVQNAKAAFK--IWSQKSGMERCRILLEAARIIREREDE 90 +P TG VIA+ + +V+LAV+ A+ AF W + +G ER RIL A +I E +E Sbjct: 58 DPRTGEVIASIAEGDKADVDLAVKAAREAFDNGPWPRMTGYERGRILHRFADLIDEHVEE 117 Query: 91 IATMECINNGK--SIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLG 148 +A ++ ++ GK ++ +AR DI + L YYAG A + G +++ GYT +EP+G Sbjct: 118 LAALDTVDAGKLFAVGKAR-DIPGAAHLLRYYAGAADKVHGATLKMAQRMHGYTLKEPVG 176 Query: 149 VCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNV 208 V I WNYP + +K PALA G A+V KP+ TP+SAL A + EAGVP G+ NV Sbjct: 177 VVGHIVPWNYPTTMFFFKVGPALAAGCAVVVKPAEQTPLSALFYAHLAREAGVPAGVLNV 236 Query: 209 VQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK-GIKPVTLELGGKSPLIIFSD 266 V G G G + H DV KVSFTGS G +M +A+ +KPV+LELGGKSP+I+F D Sbjct: 237 VPGFGPTAGAAVAAHMDVDKVSFTGSTEVGRLVMRAAAESNLKPVSLELGGKSPVIVFDD 296 Query: 267 CDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTR 326 D++ AV A + +G++C GTR++VQ+ I D+F ++ + + +GDP Sbjct: 297 ADLDMAVNLVNFATYTNKGEICVAGTRIYVQEGIYDEFVKKAAELASKSVVGDPFNPSVS 356 Query: 327 MGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMT 386 GP +++ E+VL ++ + K +GA ++ GG P GYY+ P + T+ +DDMT Sbjct: 357 QGPQVDKDQYEKVLRYIDIGKREGATLVTGGK------PCGDKGYYIEPTIFTDVKDDMT 410 Query: 387 CVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFIN 446 ++EIFGPVM+++ F T EV+++AN+T +GLAAG+ T++I A+ V ++AG +IN Sbjct: 411 IAQDEIFGPVMALMKFKTVEEVIQKANNTRYGLAAGIVTKNIDVANTVSRSIRAGAIWIN 470 Query: 447 NYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 487 Y + PFGGYK SGFG++ G ++ Y Q KTV + Sbjct: 471 CYFAFDPDAPFGGYKMSGFGKDMGMDALDKYLQTKTVVTPL 511 >3IWK-A nrPDB Length = 503 Score = 347 bits (890), Expect = 7e-96, Method: Compositional matrix adjust. Identities = 193/466 (41%), Positives = 276/466 (59%), Gaps = 14/466 (3%) Query: 34 PATGRVIATFTCSGEKEVNLAVQNAKAAF-----KIWSQKSGMERCRILLEAARIIRERE 88 P+T +I + +++V+LAV AK A + WS SG R R L A I+E++ Sbjct: 30 PSTENIIGDIPAATKEDVDLAVDAAKRAISRKNGRDWSAASGSLRARYLRAIAAKIKEKK 89 Query: 89 DEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEH---IQLPGGSF-GYTRR 144 DE+ +E I+ GK + EA D+D C EYYAGLA + + I LP +F Y + Sbjct: 90 DELGKLESIDCGKPLEEALADLDDVVACFEYYAGLAEELDSKQKAPISLPMDTFKSYILK 149 Query: 145 EPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPG 204 EP+GV I WNYPF +A+WK APALA G A + KPS V+ L L EI E G+P G Sbjct: 150 EPIGVVALITPWNYPFLMATWKIAPALAAGCAAILKPSELASVTCLELGEICKEVGLPRG 209 Query: 205 LFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLII 263 + N+V G G G L HPDV K+SFTGS TG KIM +A+ +KPV+LELGGKSP+++ Sbjct: 210 VLNIVTGLGHEAGASLASHPDVDKISFTGSSATGSKIMTTAAQLVKPVSLELGGKSPIVV 269 Query: 264 FSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLE 323 F D D++ + + F T GQ+C +R+ V + I +F +++VK + IKI DPL E Sbjct: 270 FEDVDLDKVAEWTVFGCFFTNGQICSATSRLIVHESIAVEFVDKLVKWAENIKISDPLEE 329 Query: 324 DTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRD 383 R+GP+++ ++VL + AK +GA +L GG PE LK GY++ P ++T+ Sbjct: 330 GCRLGPIVSEAQYKKVLNCISSAKSEGATILTGG--RRPE--HLKKGYFVEPTIITDVTT 385 Query: 384 DMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTC 443 M +EE+FGPV+++ +F TE E + ANDT +GL + V + D++R R+ LQAG Sbjct: 386 SMQIWREEVFGPVLAVKTFSTEEEAINLANDTHYGLGSAVMSNDLERCERLSKALQAGIV 445 Query: 444 FINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGD 489 +IN S ++ P+GG K+SGFGRE G +E Y +K V D Sbjct: 446 WINCAQPSFIQAPWGGIKRSGFGRELGEWGLENYLSVKQVTRYTSD 491 >1O9J-A nrPDB Length = 501 Score = 341 bits (874), Expect = 4e-94, Method: Compositional matrix adjust. Identities = 186/467 (39%), Positives = 276/467 (59%), Gaps = 12/467 (2%) Query: 32 FEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI---WSQKSGMERCRILLEAARIIRERE 88 F PAT I + +++V+ AV+ A+ AF++ W ER +++ + A +I Sbjct: 41 FNPATEEKICEVEEADKEDVDKAVKAAREAFQMGSPWRTMDASERGQLIYKLADLIERDR 100 Query: 89 DEIATMECINNGKSIFEARL-DIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPL 147 +AT+E IN GK A L D+D + L Y AG A + G I + G F YTR EP+ Sbjct: 101 LLLATLESINAGKVFASAYLMDLDYCIKALRYCAGWADKIQGRTIPVDGEFFSYTRHEPI 160 Query: 148 GVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFN 207 GVC I WN P + + K PAL CGN ++ KP+ TP++AL +A + EAG PPG+ N Sbjct: 161 GVCGLIFPWNAPMILLACKIGPALCCGNTVIVKPAEQTPLTALHVASLIKEAGFPPGVVN 220 Query: 208 VVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK-GIKPVTLELGGKSPLIIFS 265 +V G G G + H DV KV+FTGS G I E +AK +K VTLELG K+P I+F+ Sbjct: 221 IVPGYGPTAGAAISSHMDVDKVAFTGSTEVGKMIQEAAAKSNLKRVTLELGAKNPCIVFA 280 Query: 266 DCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDT 325 D D+++AV+ A F QGQ C +++FV++ I D+F + V++ ++ G+PL Sbjct: 281 DADLDSAVEFAHQGVFTNQGQSCIAASKLFVEEAIYDEFVQRSVERAKKYVFGNPLTPGV 340 Query: 326 RMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDM 385 GP IN+ +++ ++ K++GAK+ CGG P GY+++P V +N DDM Sbjct: 341 NHGPQINKAQHNKIMELIESGKKEGAKLECGGG------PWGNKGYFIQPTVFSNVTDDM 394 Query: 386 TCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFI 445 KEEIFGPV I+ F + EV++RAN+T +GL AGVFT+D+ +A V + LQAGT ++ Sbjct: 395 RIAKEEIFGPVQQIMKFKSLDEVIKRANNTYYGLVAGVFTKDLDKAVTVSSALQAGTVWV 454 Query: 446 NNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDVES 492 N Y + + P GG+K SG GRE G I Y+++KTV +++ + S Sbjct: 455 NCYLAASAQSPAGGFKMSGHGREMGEYGIHEYTEVKTVTMKISEKNS 501 >4MPY-A nrPDB Length = 520 Score = 340 bits (873), Expect = 7e-94, Method: Compositional matrix adjust. Identities = 181/468 (38%), Positives = 272/468 (58%), Gaps = 7/468 (1%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI--WSQKSGM 71 Y G VE A+ + T P VI T + +++ A+ A+ AF+ WSQ++ Sbjct: 36 YIDGEWVESANKN-TRDIINPYNQEVIFTVSEGTKEDAERAILAARRAFESGEWSQETAE 94 Query: 72 ERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEH 131 R + + A I+E + +A +E ++ GK++ E+ D+D Y+AGLA GE Sbjct: 95 TRGKKVRAIADKIKEHREALARLETLDTGKTLEESYADMDDIHNVFMYFAGLADKDGGEM 154 Query: 132 IQLP-GGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSAL 190 I P + +EP+GV I WNYP ASWK APALA G ++V KPS TP++ + Sbjct: 155 IDSPIPDTESKIVKEPVGVVTQITPWNYPLLQASWKIAPALATGCSLVMKPSEITPLTTI 214 Query: 191 LLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIK 249 + E+ E G P G N++ G G+ G + H +V VSFTG + TG IM+ +A + Sbjct: 215 RVFELMEEVGFPKGTINLILGAGSEVGDVMSGHKEVDLVSFTGGIETGKHIMKNAANNVT 274 Query: 250 PVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVV 309 + LELGGK+P IIF D D AV AL + GQVC G+R+ VQ I DKF + ++ Sbjct: 275 NIALELGGKNPNIIFDDADFELAVDQALNGGYFHAGQVCSAGSRILVQNSIKDKFEQALI 334 Query: 310 KQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKD 369 + ++IK+G+ DT MGP+I+ H ++ ++ VAK +GA + GG P+ LKD Sbjct: 335 DRVKKIKLGNGFDADTEMGPVISTEHRNKIESYMDVAKAEGATIAVGGK--RPDRDDLKD 392 Query: 370 GYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQ 429 G + P V+TNC M V+EE+FGPV+++ F+TE E ++ AND+ +GLA VF++DI Sbjct: 393 GLFFEPTVITNCDTSMRIVQEEVFGPVVTVEGFETEQEAIQLANDSIYGLAGAVFSKDIG 452 Query: 430 RAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYY 477 +A RV +L+ GT +IN+++ + P+GGYK+SG GRE G+ +E Y Sbjct: 453 KAQRVANKLKLGTVWINDFHPYFAQAPWGGYKQSGIGRELGKEGLEEY 500 >4I8Q-A nrPDB Length = 514 Score = 338 bits (866), Expect = 4e-93, Method: Compositional matrix adjust. Identities = 192/479 (40%), Positives = 281/479 (58%), Gaps = 15/479 (3%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAF--KIWSQKSGM 71 Y GG EP + PAT +I + ++V++AV+ A+ A W +G Sbjct: 27 YIGGEWREPVKKNRI-PIINPATEEIIGDIPAATAEDVDIAVEAARKAIARDDWGSTTGA 85 Query: 72 ERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEH 131 +R + L A + E++ +AT+E +++GK+++E+ D+D C EYYAGLA ++ Sbjct: 86 QRAKYLRAIAAKVLEKKSVLATLESLDSGKTLYESAADMDDVAGCFEYYAGLAEALDSRR 145 Query: 132 ---IQLPGGSF-GYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPV 187 + L S+ Y REPLGV I WNYP +A WK APALA G A + KPS + Sbjct: 146 MTPVNLNSDSYKSYVLREPLGVVGLITPWNYPLLMAIWKVAPALAAGCAAILKPSELASI 205 Query: 188 SALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK 246 + L L EI E G+P G N++ G G G L HP V K+SFTGS PTG KIM +A+ Sbjct: 206 TCLELGEICREIGLPSGALNILTGLGPEAGGPLASHPHVDKISFTGSGPTGSKIMTAAAQ 265 Query: 247 GIKPVTLELGGKSPLIIFSDCD-MNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFT 305 +KPV+L LGGKSP+++F D D ++ A + L F GQVC +R+ VQ+ I F Sbjct: 266 LVKPVSLALGGKSPIVVFDDIDNLDIAAEWTLFGIFANTGQVCSATSRLIVQENIASAFM 325 Query: 306 EEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDP 365 + ++K T+ IKI DPL ED ++GP+++ E+VL F+ AK +GA +LCGG E P Sbjct: 326 DRLLKWTKNIKISDPLEEDCKLGPVVSAGQYEKVLKFISNAKSEGATILCGG-----ERP 380 Query: 366 K-LKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVF 424 + LK GYY++P ++T+ M KEE+FGPV+ + +F TE + +E ANDT +GL A V Sbjct: 381 QHLKKGYYVQPTIITDVNTSMEIWKEEVFGPVLCVKTFKTEEQAIELANDTKYGLGAAVM 440 Query: 425 TRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTV 483 ++D++R R Q G +IN + ELP+GG K+SGFGR+ G+ +E + +K V Sbjct: 441 SKDVKRCERFTKAFQTGIIWINCSQPTFNELPWGGKKRSGFGRDLGKWGLENFLNIKQV 499 >3IWJ-A nrPDB Length = 503 Score = 335 bits (859), Expect = 3e-92, Method: Compositional matrix adjust. Identities = 187/462 (40%), Positives = 270/462 (58%), Gaps = 14/462 (3%) Query: 32 FEPATGRVIATFTCSGEKEVNLAVQNAKAAFK-----IWSQKSGMERCRILLEAARIIRE 86 PAT +I + +++V++AV AK A W+ SG R R L A + E Sbjct: 28 INPATQNIIGDIPAATKEDVDVAVAAAKTALTRNKGADWATASGAVRARYLRAIAAKVTE 87 Query: 87 REDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEH---IQLPGGSF-GYT 142 ++ E+A +E I+ GK + EA DID C EYYA LA + + LP +F + Sbjct: 88 KKPELAKLESIDCGKPLDEAAWDIDDVAGCFEYYADLAEKLDARQKAPVSLPMDTFKSHV 147 Query: 143 RREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVP 202 REP+GV I WNYP +A+WK APALA G A + KPS ++ L L EI E G+P Sbjct: 148 LREPIGVVGLITPWNYPMLMATWKVAPALAAGCAAILKPSELASLTCLELGEICKEVGLP 207 Query: 203 PGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPL 261 PG+ N++ G G G L HPDV KV+FTGS TG KIM +A+ +KPV+LELGGKSPL Sbjct: 208 PGVLNILTGLGPEAGAPLATHPDVDKVAFTGSSATGSKIMTAAAQLVKPVSLELGGKSPL 267 Query: 262 IIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPL 321 ++F D D++ A + A+ F T GQ+C +R+ + + I +F +VK + IKI DPL Sbjct: 268 VVFEDVDLDKAAEWAIFGCFWTNGQICSATSRLILHESIATEFLNRIVKWIKNIKISDPL 327 Query: 322 LEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNC 381 E R+GP+++ E++L FV AK +GA +L GG PE LK G+++ P ++T+ Sbjct: 328 EEGCRLGPVVSEGQYEKILKFVSNAKSEGATILTGGS--RPE--HLKKGFFIEPTIITDV 383 Query: 382 RDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAG 441 +M +EE+FGPV+ + +F TE E ++ ANDT +GL A V + D++R RV +AG Sbjct: 384 TTNMQIWREEVFGPVLCVKTFSTEEEAIDLANDTVYGLGAAVISNDLERCERVTKAFKAG 443 Query: 442 TCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTV 483 ++N + P+GG K+SGFGRE G ++ Y +K V Sbjct: 444 IVWVNCSQPCFTQAPWGGVKRSGFGRELGEWGLDNYLSVKQV 485 >4U3W-A nrPDB Length = 505 Score = 332 bits (850), Expect = 3e-91, Method: Compositional matrix adjust. Identities = 189/472 (40%), Positives = 273/472 (57%), Gaps = 10/472 (2%) Query: 25 ASGTE-KAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI-WSQKSGMERCRILLEAAR 82 ASGT P GR +A + V+ AVQ A AA K W + +R L + A Sbjct: 34 ASGTTFPNLSPVDGRKLADVCEADAALVDSAVQAAHAAQKAGWRDTTPAQRAAWLHKIAD 93 Query: 83 IIREREDEIATMECINNGKSIFEAR-LDIDISWQCLEYYAGLAASMAGEHIQLPGGS--- 138 I R DE E + G+ + +AR LDI +A L + +GE+ + Sbjct: 94 GIEARFDEFVAAEVADTGRPVAQARTLDIARGIANFRTFADLVRTASGEYFETHAADGSE 153 Query: 139 -FGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYS 197 Y R+PLGV I WN P + +WK APALA GN +V KPS TP SA LLAE+ Sbjct: 154 LINYVTRKPLGVIGIISPWNLPLLLFTWKVAPALAMGNCVVAKPSEETPSSATLLAEVMH 213 Query: 198 EAGVPPGLFNVVQGGA--ATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLEL 255 + G+PPG+FN++ G A G+FL +HPD++ ++FTG TG IM+ A G+K V+ EL Sbjct: 214 DVGLPPGVFNLIHGHGQNAAGEFLTRHPDISAITFTGESRTGSTIMKAVADGVKEVSFEL 273 Query: 256 GGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRI 315 GGK+ ++F+D D + AV G L ++F GQVC RV+V++ I ++F + +Q Q + Sbjct: 274 GGKNAAVVFADADFDAAVAGVLRSSFTNAGQVCLCSERVYVERPIFERFVAALKEQAQAL 333 Query: 316 KIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRP 375 ++G P T MGPLI+R H ++VL + ++A E+GA V+ GG D + DG ++ P Sbjct: 334 RVGAPEDPATTMGPLISRGHRDKVLSYFRLAVEEGATVVTGGGAPSFGDAR-DDGAFVMP 392 Query: 376 CVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVV 435 + T D CV+EEIFGPV I FD EAEV++R ND+ +GLAA ++T + R HRV Sbjct: 393 TIWTGLPDSARCVREEIFGPVCHIAPFDDEAEVVKRVNDSAYGLAASIWTTQLARGHRVA 452 Query: 436 AELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 487 +++ G ++N + V + PFGG K SG GRE GR ++++YS+L VCV + Sbjct: 453 KQIETGIVWVNAWFVRDLRTPFGGTKLSGLGREGGRHSLDFYSELTNVCVRI 504 >5FHZ-A nrPDB Length = 529 Score = 331 bits (848), Expect = 6e-91, Method: Compositional matrix adjust. Identities = 173/462 (37%), Positives = 270/462 (58%), Gaps = 12/462 (2%) Query: 34 PATGRVIATFTCSGEKEVNLAVQNAKAAFK---IWSQKSGMERCRILLEAARIIREREDE 90 P+T I + +V+ AV+ A+ AF+ W + + R R+L + A ++ Sbjct: 71 PSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRAT 130 Query: 91 IATMECINNGKSIFEAR-LDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGV 149 +A +E ++ GK A +D++ + L Y+AG A + G+ I +TR EP+GV Sbjct: 131 LAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGV 190 Query: 150 CVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVV 209 C I WN+P + WK APAL CGN MV KP+ TP++AL L + EAG PPG+ N+V Sbjct: 191 CGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIV 250 Query: 210 QG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK-GIKPVTLELGGKSPLIIFSDC 267 G G G + HP + K++FTGS G + E +++ +K VTLELGGK+P I+ +D Sbjct: 251 PGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADA 310 Query: 268 DMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRM 327 D++ AV+ A F QGQ C +RVFV++++ +F V+ ++ +GDP T Sbjct: 311 DLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQ 370 Query: 328 GPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTC 387 GP I++ +++L ++ K++GAK+ CGG ED G +++P V + D+M Sbjct: 371 GPQIDQKQFDKILELIESGKKEGAKLECGGSAM--ED----KGLFIKPTVFSEVTDNMRI 424 Query: 388 VKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN 447 KEEIFGPV IL F + EV++RAN T +GL A VFT+++ +A ++ + L++GT +IN Sbjct: 425 AKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINC 484 Query: 448 YNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGD 489 YN + PFGG+K SG GRE G + Y+++KTV +++GD Sbjct: 485 YNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKLGD 526 >4QYJ-A nrPDB Length = 516 Score = 326 bits (836), Expect = 1e-89, Method: Compositional matrix adjust. Identities = 181/474 (38%), Positives = 271/474 (57%), Gaps = 16/474 (3%) Query: 23 ADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFK--IWSQKSGMERCRILLEA 80 A + T + PATG ++ ++VN AV++A A + W + R RILL Sbjct: 46 AQSGKTLNVYNPATGDILTEVPDGDVEDVNAAVESAAATLRSDTWRRMPPSARERILLRL 105 Query: 81 ARIIREREDEIATMECINNGKSIFEARL-DIDISWQCLEYYAGLAASMAGEHIQLP---- 135 A ++ DE+A +E +NNGK + ++L ++ S Q L Y AG A + G + L Sbjct: 106 ADLLEVHGDELARLETLNNGKLLIYSKLMEVGASAQWLRYMAGWATKLTGSTLDLSLPLP 165 Query: 136 --GGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLA 193 S T+R P+GV I WN+P +A WK APALACGN +V KP+ TP++AL LA Sbjct: 166 PEVRSRASTQRVPVGVVAAIIPWNFPLLMAVWKIAPALACGNTVVLKPAEETPLTALRLA 225 Query: 194 EIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVT 252 E+ EAG+P G NVV G G G L +HP VAKV+FTGS G I + +K V+ Sbjct: 226 ELAMEAGLPAGALNVVTGRGETAGDALVRHPKVAKVAFTGSTEVGRIIGSACGRSLKAVS 285 Query: 253 LELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQT 312 LELGGKSP+I+ +DCD A +GA A F GQVC G+R++V + I + + + Sbjct: 286 LELGGKSPVIVLADCDPQEAAEGAAAAIFFNHGQVCTAGSRLYVHESIYEDVIQRLAVIG 345 Query: 313 QRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYY 372 + I +G L + MGP++++ H E VL ++ E GA ++CGG E P G++ Sbjct: 346 ESIVVGSGLEQGVHMGPMVSKKHHENVLRHIRNGIEDGADLICGGT----EAP-CAQGFF 400 Query: 373 MRPCVLTNC-RDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRA 431 ++P + N + D+ + +E+FGPV+ F AEV+ AN + +GL A ++T D+ A Sbjct: 401 VKPTIFANREKKDIRLLSQEVFGPVLVATPFSDIAEVVNEANRSVYGLGASIWTNDLSAA 460 Query: 432 HRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCV 485 R+ EL+AGT ++N +N+ LPFGG+K SG GRE+G IE+Y+ +++ + Sbjct: 461 LRINDELEAGTVWVNTHNMVDPNLPFGGFKDSGVGREHGAAAIEHYTTTRSLVI 514 >4I8P-A nrPDB Length = 520 Score = 322 bits (825), Expect = 2e-88, Method: Compositional matrix adjust. Identities = 174/430 (40%), Positives = 248/430 (57%), Gaps = 9/430 (2%) Query: 65 WSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLA 124 W++ G R + L A + ER+ E+A +E ++ GK EA D+D C EY+A A Sbjct: 83 WARAPGAVRAKYLRAIAAKVIERKPELAKLEALDCGKPYDEAAWDMDDVAGCFEYFADQA 142 Query: 125 ASMAGEH---IQLPGGSFG-YTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFK 180 ++ + LP +F + RREP+GV I WNYP +A+WK APALA G V K Sbjct: 143 EALDKRQNSPVSLPMETFKCHLRREPIGVVGLITPWNYPLLMATWKIAPALAAGCTAVLK 202 Query: 181 PSPFTPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMK 239 PS V+ L LA+I E G+P G+ N+V G G G L HPDV KV+FTGS TG K Sbjct: 203 PSELASVTCLELADICKEVGLPSGVLNIVTGLGPDAGAPLSAHPDVDKVAFTGSFETGKK 262 Query: 240 IMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKE 299 IM +A +KPVTLELGGKSP+++F D D++ AV+ L F T GQ+C +R+ + + Sbjct: 263 IMASAAPMVKPVTLELGGKSPIVVFDDVDIDKAVEWTLFGCFWTNGQICSATSRLLIHTK 322 Query: 300 ILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDI 359 I KF E +V + IK+ DPL E R+GP+++ E++ F+ AK QGA +L GG Sbjct: 323 IAKKFNERMVAWAKNIKVSDPLEEGCRLGPVVSEGQYEKIKKFISNAKSQGATILTGG-- 380 Query: 360 YVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGL 419 L+ G+++ P ++T+ M +EE+FGPV+ + F TE E +E ANDT +GL Sbjct: 381 --VRPAHLEKGFFIEPTIITDITTSMEIWREEVFGPVLCVKEFSTEDEAIELANDTQYGL 438 Query: 420 AAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQ 479 A V + D +R R+ E+ AG ++N + P+GG K+SGFGRE G I+ Y Sbjct: 439 AGAVISGDRERCQRLSEEIDAGCIWVNCSQPCFCQAPWGGNKRSGFGRELGEGGIDNYLS 498 Query: 480 LKTVCVEMGD 489 +K V + D Sbjct: 499 VKQVTEYISD 508 >3U4J-A nrPDB Length = 528 Score = 307 bits (786), Expect = 7e-84, Method: Compositional matrix adjust. Identities = 185/476 (38%), Positives = 271/476 (56%), Gaps = 9/476 (1%) Query: 17 GARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI--WSQKSGMERC 74 G V+ A S ++ G V+ T+ + +V AV A+ AF W + SG ER Sbjct: 29 GKSVDAASGSTIDRVSPGHAGEVVGTWPEASADDVRKAVAAARKAFDAGPWPRMSGAERS 88 Query: 75 RILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGE-HIQ 133 R++ + A +I R++E+A +E + GK I +AR +I Y AG A ++ G+ H Sbjct: 89 RLMFKVADLILARQEELALIESLEVGKPIAQARGEIGFCADLWSYAAGQARALEGQTHNN 148 Query: 134 LPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLA 193 + G REP+GV I WN+PF IAS + A+ G +V KPS FT +++ LA Sbjct: 149 IGDDRLGLVLREPVGVVGIITPWNFPFIIASERVPWAIGSGCTVVLKPSEFTSGTSIRLA 208 Query: 194 EIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVT 252 E+ EAG+P G+FNVV G G GQ L + P+V V+FTGSV G K+ E++A+ +K V Sbjct: 209 ELAREAGIPDGVFNVVTGYGDPAGQVLAEDPNVDMVAFTGSVRVGTKLGEIAARTVKRVG 268 Query: 253 LELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQT 312 LELGGK P I+F+D D++ A G + GQ C +G+R+ VQ+ I D E ++ + Sbjct: 269 LELGGKGPQIVFADADLDAAADGIAYGVYHNAGQCCISGSRLLVQEGIRDALMERLLDIS 328 Query: 313 QRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYY 372 +++ GDPL E T++G +I+ H E+V +V GA++L GG E + G Y Sbjct: 329 RKVAFGDPLNERTKIGAMISEAHAEKVHSYVTAGITSGAELLLGG-----ERIGREAGLY 383 Query: 373 MRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAH 432 P V DM+ +EEIFGPV+S L+F T E + AN T FGL+A V++ +++ A Sbjct: 384 YAPTVFAGVTPDMSIAREEIFGPVLSTLTFKTADEAVALANATEFGLSASVWSTNLETAL 443 Query: 433 RVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMG 488 + + ++AG C+IN+ ELP GGYKKSG GRE GR + YSQ K V V +G Sbjct: 444 QTIRRIRAGRCWINSVIDGTPELPIGGYKKSGLGRELGRYGFDEYSQFKGVHVTLG 499 >3JZ4-A nrPDB Length = 481 Score = 304 bits (779), Expect = 5e-83, Method: Compositional matrix adjust. Identities = 171/456 (37%), Positives = 250/456 (54%), Gaps = 12/456 (2%) Query: 34 PATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIAT 93 PA G + + G E A+ A A W + ER IL ++ E +D++A Sbjct: 32 PANGDKLGSVPKMGADETRAAIDAANRALPAWRALTAKERATILRNWFNLMMEHQDDLAR 91 Query: 94 MECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFG---YTRREPLGVC 150 + + GK + EA+ +I + +E++A + G+ I PG ++P+GV Sbjct: 92 LMTLEQGKPLAEAKGEISYAASFIEWFAEEGKRIYGDTI--PGHQADKRLIVIKQPIGVT 149 Query: 151 VGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQ 210 I WN+P + + K+ PALA G MV KP+ TP SAL LAE+ AGVP G+FNVV Sbjct: 150 AAITPWNFPAAMITRKAGPALAAGCTMVLKPASQTPFSALALAELAIRAGVPAGVFNVVT 209 Query: 211 GGA-ATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDM 269 G A A G L +P V K+SFTGS G ++ME AK IK V+LELGG +P I+F D D+ Sbjct: 210 GSAGAVGNELTSNPLVRKLSFTGSTEIGRQLMEQCAKDIKKVSLELGGNAPFIVFDDADL 269 Query: 270 NNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGP 329 + AV+GAL + F GQ C R++VQ + D+F E++ + ++ IGD L +GP Sbjct: 270 DKAVEGALASKFRNAGQTCVCANRLYVQDGVYDRFAEKLQQAMSKLHIGDGLDNGVTIGP 329 Query: 330 LINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVK 389 LI+ + +V + A E+GA+V+CGG + + G + +P +L + + K Sbjct: 330 LIDEKAVAKVEEHIADALEKGARVVCGGKAHE------RGGNFFQPTILVDVPANAKVSK 383 Query: 390 EEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYN 449 EE FGP+ + F EA+V+ +ANDT FGLAA + RD+ R RV L+ G IN Sbjct: 384 EETFGPLAPLFRFKDEADVIAQANDTEFGLAAYFYARDLSRVFRVGEALEYGIVGINTGI 443 Query: 450 VSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCV 485 +S PFGG K SG GRE + IE Y ++K +C+ Sbjct: 444 ISNEVAPFGGIKASGLGREGSKYGIEDYLEIKYMCI 479 >4O5H-A nrPDB Length = 511 Score = 303 bits (775), Expect = 1e-82, Method: Compositional matrix adjust. Identities = 181/488 (37%), Positives = 271/488 (55%), Gaps = 16/488 (3%) Query: 8 VSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI--W 65 +++P GA A + PA G VIA + E++V AV A+ AF W Sbjct: 27 LAKPKQMLIGAEWSDAASGRQLDVVNPADGTVIARVPEADERDVQQAVAAARRAFDAGPW 86 Query: 66 SQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEAR-LDIDISWQCLEYYAGLA 124 +R R++L A +I E+A +E ++NGK + A+ LD+ ++ QC Y AG A Sbjct: 87 RTAKTTDRERLMLVLADLIEANARELAEIESLDNGKPVMVAQGLDVAMAAQCFRYMAGWA 146 Query: 125 ASMAGEHIQ-----LPGGS-FGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMV 178 + G I LP F YTR+EP+GV I WN+P +A+WK APALA G +V Sbjct: 147 TKIEGSVIDAGMPYLPDSEIFAYTRKEPVGVVGAIIPWNFPLLMAAWKIAPALATGCTVV 206 Query: 179 FKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTG 237 KP+ TP+SAL L E+ AG P G+ N+V G G G L + P + K++FTGS TG Sbjct: 207 LKPAEDTPLSALRLGELIQAAGFPDGVVNIVTGYGHTAGAALSRDPRIDKIAFTGSTQTG 266 Query: 238 MKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQ 297 I + + ++LELGGKSP+I+ D D++ A +G A F QGQVC G+R ++ Sbjct: 267 KTIGHAALDNMTRMSLELGGKSPVIVLPDVDLDKAAQGVANAIFFNQGQVCTAGSRAYIH 326 Query: 298 KEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGG 357 ++ D E V K +KIG + T++GPL++ ERV G++ +GA+ GG Sbjct: 327 SKVFDGVIERVAKIAASLKIGPGMDPATQIGPLVSAKQRERVCGYIDSGFGEGARAAAGG 386 Query: 358 DIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTF 417 + P G+++ P VL + M V+EEIFGPV+ + FD ++ ANDT + Sbjct: 387 RAI--DGP----GFFVEPTVLVDTTQAMRVVREEIFGPVLVAMPFDDVDTAVQLANDTPY 440 Query: 418 GLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYY 477 GL A +++ D+ H++V + AGT ++N +++ LPFGG K+SGFGRE GR I+ Y Sbjct: 441 GLGASIWSNDLSAIHKLVPRIAAGTVWVNCHSLLDNALPFGGMKQSGFGRELGRAVIDQY 500 Query: 478 SQLKTVCV 485 ++ K+V + Sbjct: 501 TESKSVMM 508 >3TY7-A nrPDB Length = 478 Score = 293 bits (750), Expect = 1e-79, Method: Compositional matrix adjust. Identities = 178/479 (37%), Positives = 267/479 (55%), Gaps = 23/479 (4%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMER 73 Y G VE ++++ T + PAT VI + +V+ AV+ A + + S ER Sbjct: 11 YINGEWVE-SNSNETIEVINPATEEVIGKVAKGNKADVDKAVEAADDVYLEFRHTSVKER 69 Query: 74 CRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQ 133 +L + + R+D+I ++ I + E + +S + + Y GL +A Sbjct: 70 QALLDKIVKEYENRKDDI--VQAITD-----ELGAPLSLS-ERVHYQMGLNHFVAARD-A 120 Query: 134 LPGGSFGYTR------REPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPV 187 L F R +E +GV I WN+P S K A A A G+ +V KPS TP Sbjct: 121 LDNYEFEERRGDDLVVKEAIGVSGLITPWNFPTNQTSLKLAAAFAAGSPVVLKPSEETPF 180 Query: 188 SALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK 246 +A++LAEI+ + GVP G+FN+V G GA G L +HP V +SFTGS PTG KIME +AK Sbjct: 181 AAVILAEIFDKVGVPKGVFNLVNGDGAGVGNPLSEHPKVRMMSFTGSGPTGSKIMEKAAK 240 Query: 247 GIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTE 306 K V+LELGGKSP I+ D D+ A K GQVC GTRV V +I D F Sbjct: 241 DFKKVSLELGGKSPYIVLDDVDIKEAAKATTGKVVNNTGQVCTAGTRVLVPNKIKDAFLA 300 Query: 307 EVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPK 366 E+ +Q ++++G+P + T++GP+I++ ++V ++ E+GA++ GG P P+ Sbjct: 301 ELKEQFSQVRVGNPREDGTQVGPIISKKQFDQVQNYINKGIEEGAELFYGG----PGKPE 356 Query: 367 -LKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFT 425 L+ GY+ RP + N + MT +EEIFGPVMS+++++ E ++ ANDT +GLA V Sbjct: 357 GLEKGYFARPTIFINVDNQMTIAQEEIFGPVMSVITYNDLDEAIQIANDTKYGLAGYVIG 416 Query: 426 RDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVC 484 +D + H+V ++AGT IN P +LPFGGYK+SG GRE G IE + ++K++ Sbjct: 417 KDKETLHKVARSIEAGTVEINEAGRKP-DLPFGGYKQSGLGREWGDYGIEEFLEVKSIA 474 >1WNB-A nrPDB Length = 495 Score = 291 bits (746), Expect = 3e-79, Method: Compositional matrix adjust. Identities = 178/462 (38%), Positives = 256/462 (55%), Gaps = 17/462 (3%) Query: 32 FEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEI 91 + PATG V+ + ++V+ AV+ A AAF W Q + R LL+ A +I E Sbjct: 43 YNPATGDVLLEIAEASAEQVDAAVRAADAAFAEWGQTTPKVRAECLLKLADVIEENGQVF 102 Query: 92 ATMECINNGKSIFEARLD-IDISWQCLEYYAGLAASM----AGEHIQLPGGSFGYTRREP 146 A +E N GK + A D I ++AG A + AGE+++ G RR+P Sbjct: 103 AELESRNCGKPLHSAFNDEIPAIVDVFRFFAGAARCLNGLAAGEYLE---GHTSMIRRDP 159 Query: 147 LGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLF 206 LGV I WNYP +A+WK APALA GN +V KPS TP++AL LAE+ + P G+ Sbjct: 160 LGVVASIAPWNYPLMMAAWKLAPALAAGNCVVLKPSEITPLTALKLAELAKDI-FPAGVV 218 Query: 207 NVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFS 265 N++ G G G L HP V VS TGS+ TG I+ +A IK +ELGGK+P+I+F Sbjct: 219 NILFGRGKTVGDPLTGHPKVRMVSLTGSIATGEHIISHTASSIKRTHMELGGKAPVIVFD 278 Query: 266 DCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDT 325 D D+ V+G + GQ C R++ QK I D E++ +K G P E T Sbjct: 279 DADIEAVVEGVRTFGYYNAGQDCTAACRIYAQKGIYDTLVEKLGAAVATLKSGAPDDEST 338 Query: 326 RMGPLINRPHLERVLGFVKVAKEQGA-KVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDD 384 +GPL + HLERV V+ AK G KV+ GG+ + +GYY P +L D Sbjct: 339 ELGPLSSLAHLERVGKAVEEAKATGHIKVITGGE------KRKGNGYYYAPTLLAGALQD 392 Query: 385 MTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCF 444 V++E+FGPV+S+ FD E +V+ AND+ +GLA+ V+T+D+ RAHRV A LQ G + Sbjct: 393 DAIVQKEVFGPVVSVTPFDNEEQVVNWANDSQYGLASSVWTKDVGRAHRVSARLQYGCTW 452 Query: 445 INNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 486 +N + + E+P GG K SG+G++ +E Y+ ++ V V+ Sbjct: 453 VNTHFMLVSEMPHGGQKLSGYGKDMSLYGLEDYTVVRHVMVK 494 >6C43-A nrPDB Length = 477 Score = 287 bits (735), Expect = 6e-78, Method: Compositional matrix adjust. Identities = 173/465 (37%), Positives = 253/465 (54%), Gaps = 17/465 (3%) Query: 29 EKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIRERE 88 + + PATG VI + +V+ AVQ A AF W Q + R LL+ A I + Sbjct: 22 QSVYNPATGEVILEIAEASPAQVDAAVQAADNAFAEWGQTTPKARAECLLKLADSIEQNA 81 Query: 89 DEIATMECINNGKSIFEARLD-IDISWQCLEYYAG----LAASMAGEHIQLPGGSFGYTR 143 E A +E N GK + D I ++AG L+ AGE+++ G R Sbjct: 82 LEFARLESQNCGKPLHCVINDEIPAIVDVFRFFAGAARCLSGLAAGEYLE---GHTSMIR 138 Query: 144 REPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPP 203 R+P+GV I WNYP +A+WK APALA GN +V KPS TP++AL LA + ++ PP Sbjct: 139 RDPIGVVASIAPWNYPLMMAAWKLAPALAAGNCVVIKPSEITPLTALKLA-VLAKDIFPP 197 Query: 204 GLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLI 262 G+ NV+ G G G L H V VS TGS+ TG I+ +A IK +ELGGK+P+I Sbjct: 198 GVLNVLFGRGQTVGDVLTGHEKVRMVSLTGSIATGEHILRHTAPAIKRTHMELGGKAPVI 257 Query: 263 IFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLL 322 +F D D++ +G F GQ C R++ Q+ I D E++ +K+G P Sbjct: 258 VFDDADLDAVAQGVRTFGFYNAGQDCTAACRIYAQRGIYDALVEKLGNAVSSLKMGAPED 317 Query: 323 EDTRMGPLINRPHLERVLGFVKVAKE-QGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNC 381 E T +GPL + HL+RV V+ AK +V+ GG GYY P +L + Sbjct: 318 ESTELGPLSSLAHLKRVTAAVEEAKALSHIRVITGG------SQTEGKGYYFAPTLLADA 371 Query: 382 RDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAG 441 + + V+ E+FGPV+SI FD E +VL AND+ +GLA+ V+T+D+ RAHR+ A LQ G Sbjct: 372 KQEDAIVQREVFGPVVSITVFDDEDQVLRWANDSRYGLASSVWTQDVGRAHRLSARLQYG 431 Query: 442 TCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 486 +IN + + E+P GG K+SG+G++ +E Y+ ++ + V+ Sbjct: 432 CTWINTHFMLVSEMPHGGQKQSGYGKDMSLYGLEDYTLVRHIMVK 476 >4V6H-A nrPDB Length = 484 Score = 285 bits (730), Expect = 3e-77, Method: Compositional matrix adjust. Identities = 169/471 (35%), Positives = 254/471 (53%), Gaps = 8/471 (1%) Query: 17 GARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRI 76 G + AD+ T + F+PATG + T G E A++ A+AA+ W K+ ER I Sbjct: 18 GGEWQAADSDATFEVFDPATGESLGTVPKMGAAETARAIEAAQAAWAGWRMKTAKERAAI 77 Query: 77 LLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPG 136 L ++ D++A + GK + EA+ +I + +E++A +AG+ + P Sbjct: 78 LRRWFDLVIANSDDLALILTTEQGKPLAEAKGEIAYAASFIEWFAEEGKRVAGDTLPTPD 137 Query: 137 GSFG-YTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEI 195 + +EP+GVC I WN+P + + K PALA G +V KP+ TP SAL +A + Sbjct: 138 ANKRIVVVKEPIGVCAAITPWNFPAAMIARKVGPALAAGCPIVVKPAESTPFSALAMAFL 197 Query: 196 YSEAGVPPGLFNVVQGG-AATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLE 254 AGVP G+ +VV G A G + +P V K+SFTGS G +M SA +K +TLE Sbjct: 198 AERAGVPKGVLSVVIGDPKAIGTEITSNPIVRKLSFTGSTAVGRLLMAQSAPTVKKLTLE 257 Query: 255 LGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQR 314 LGG +P I+F D D++ AV+GA+ + + GQ C R FV + + D F +++ + Sbjct: 258 LGGNAPFIVFDDADLDAAVEGAIASKYRNNGQTCVCTNRFFVHERVYDAFADKLAAAVSK 317 Query: 315 IKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMR 374 +K+G +GPLIN +++V + A +GA ++ GG + L G++ Sbjct: 318 LKVGRGTESGATLGPLINEAAVKKVESHIADALAKGASLMTGGKRHA-----LGHGFF-E 371 Query: 375 PCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRV 434 P VLT + DM KEE FGP+ + F +E E++ ANDT FGLAA +++RDI R RV Sbjct: 372 PTVLTGVKPDMDVAKEETFGPLAPLFRFASEEELVRLANDTEFGLAAYLYSRDIGRVWRV 431 Query: 435 VAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCV 485 L+ G IN +S PFGG K+SG GRE I+ Y +K +CV Sbjct: 432 AEALEYGMVGINTGLISNEVAPFGGVKQSGLGREGSHYGIDDYVVIKYLCV 482 >5IUV-A nrPDB Length = 497 Score = 284 bits (727), Expect = 6e-77, Method: Compositional matrix adjust. Identities = 165/489 (33%), Positives = 268/489 (54%), Gaps = 14/489 (2%) Query: 9 SQPLNYRGGARVE---PADASG-TEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFK- 63 +Q L G A ++ A ASG T P GR++A + AV++A++AF Sbjct: 13 AQNLKIEGRAFIQGEYTAAASGETFDCISPVDGRLLAKVASCDAADAQRAVESARSAFDS 72 Query: 64 -IWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEAR-LDIDISWQCLEYYA 121 WS+ + +R ++ A ++ + +E+A +E ++ GK I ++ +DI + L + Sbjct: 73 GAWSRLAPAKRKATMIRFAGLLEQNAEELALLETLDMGKPISDSLGVDIPGGARALSWSG 132 Query: 122 GLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKP 181 + E P G REP+GV I WN+P +A WK PAL+ GN++V KP Sbjct: 133 EAIDKLYDEVAATPHDQLGLVTREPVGVVAAIVPWNFPLMMACWKLGPALSTGNSVVLKP 192 Query: 182 SPFTPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKI 240 S +P++A+ +A++ EAG+P G+ NV+ G G G+ L H DV V FTGS ++ Sbjct: 193 SEKSPLTAIRIAQLAIEAGIPAGVLNVLPGYGHTVGKALALHMDVDTVVFTGSTKIAKQL 252 Query: 241 MEMSAKG-IKPVTLELGGKSPLIIFSDC-DMNNAVKGALMANFLTQGQVCCNGTRVFVQK 298 M + + +K V LE GGKSP I+F+D D+ A A A QG+VC G+R+ V++ Sbjct: 253 MIYAGESNMKRVWLEAGGKSPNIVFADAPDLQAAADSAASAIAFNQGEVCTAGSRLLVER 312 Query: 299 EILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGD 358 I D+F V++ K G+PL T +G L++ + VL ++ GA+++ GG Sbjct: 313 SIKDRFLPMVIEALGTWKPGNPLDPATNVGALVDTQQMNTVLSYIAAGHTDGARLVAGGK 372 Query: 359 IYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFG 418 + E G Y+ P + + M +EEIFGPV+S+L+FDT E ++ ANDT +G Sbjct: 373 QILQE----TGGTYVEPTIFDGVNNAMRIAQEEIFGPVLSVLTFDTAEEAIQIANDTPYG 428 Query: 419 LAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYS 478 LAA V+T ++ +AH L+AG+ ++N Y+ + PFGG+K+SG GR+ + Y+ Sbjct: 429 LAAAVWTANLSKAHLTARALRAGSVWVNQYDGGDMTAPFGGFKQSGNGRDKSLHAFDKYT 488 Query: 479 QLKTVCVEM 487 +LK+ +++ Sbjct: 489 ELKSTWIKL 497 >6MVR-A nrPDB Length = 767 Score = 284 bits (726), Expect = 7e-77, Method: Compositional matrix adjust. Identities = 170/468 (36%), Positives = 266/468 (56%), Gaps = 27/468 (5%) Query: 13 NYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGME 72 ++ GGA P D T PATG+ +A + + + +V+ AV+ A+ A W+ K G Sbjct: 35 HFIGGAWTAPGDLFAT---VNPATGQTLAQVSQATQADVDAAVKAARKAQPAWA-KDGAA 90 Query: 73 RCRILLEAARIIREREDEIATMECINNGKSIFEAR-LDIDISWQCLEYYAGLAASMAGEH 131 R R+L AR++++ A +E ++NGK I EAR +D+ ++ + ++AG A M E Sbjct: 91 RARVLYALARLLQKHARLFAVLETLDNGKPIREARDIDVPLAQRHFYHHAGYAQLMGTE- 149 Query: 132 IQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALL 191 +P R PLGVC + WN+P + +WK APALA GN +V KP+ +TP++ALL Sbjct: 150 --MP-------DRAPLGVCGQVIPWNFPLLMLAWKIAPALAMGNTVVLKPAEWTPLTALL 200 Query: 192 LAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPV 251 A+I +AGVP G+ N+V G A G+ + V KV+FTGS G +I E +A K + Sbjct: 201 FADICGQAGVPAGVVNIVTGDGAVGEMIVT-AQVDKVAFTGSTAVGRRIREATAGTGKAL 259 Query: 252 TLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQ 311 +LELGGK P ++ D D+++AV+G + A + QGQVCC G+R+ VQ+ I D F ++ + Sbjct: 260 SLELGGKGPYVVCDDADIDSAVEGLVDAIWFNQGQVCCAGSRLLVQEGIADVFHAKLRAR 319 Query: 312 TQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGY 371 ++IGDPL + +G +++ L RV V + G++Y P G Sbjct: 320 MDSLRIGDPLDKCIDIGAMVHPDQLARVRDMVAANTD--------GEVYQTAVPA---GC 368 Query: 372 YMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRA 431 Y P +++ +++EIFGPV+ +F T AE +E AN+T +GLAA V++ ++ A Sbjct: 369 YYPPTLISGLAPASPLMQQEIFGPVLVSTTFRTPAEAVEIANNTAYGLAASVWSENVNLA 428 Query: 432 HRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQ 479 + +L AG +IN N+ PFGG ++SGFGRE G + Y++ Sbjct: 429 LDLAPKLVAGIVWINGTNMMDAAAPFGGVRESGFGREGGWEGLAGYTR 476 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 53/216 (24%), Positives = 89/216 (41%), Gaps = 7/216 (3%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMER 73 Y GG + P G +A G+++ + S K++ AV+ AA WS+ +G R Sbjct: 506 YIGGKQTRPD--GGYSRAVYGPKGKLLGHASLSNRKDLRNAVEAMNAASG-WSRTTGHLR 562 Query: 74 CRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQ 133 +IL + R DE A GK + + ++ S L A A G+ Sbjct: 563 AQILYFIGENLSARADEFANRIKDMTGK---DGKAEVAASIDRLFSAAAWADKYDGQVKG 619 Query: 134 LPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLA 193 +P +EP+G + P APA+A GN + S P++A Sbjct: 620 VPLRGVALAMKEPVGKIGILCPDAAPLLGLVSLMAPAIAMGNRVTLAASEAFPLAATDFY 679 Query: 194 EIYSEAGVPPGLFNVVQGGAAT-GQFLCQHPDVAKV 228 ++ + VP G+ N++ G A + + +H D+ V Sbjct: 680 QVLDTSDVPAGVVNILTGAHADLAEPMARHLDLDAV 715 >6B4R-B nrPDB Length = 497 Score = 282 bits (722), Expect = 2e-76, Method: Compositional matrix adjust. Identities = 155/462 (33%), Positives = 256/462 (55%), Gaps = 10/462 (2%) Query: 32 FEPATGRVIATFTCSGEKEVNLAVQNAKAAFK--IWSQKSGMERCRILLEAARIIRERED 89 P GR +A + AV+ A+ AF WS+ + +R + ++ A ++ E + Sbjct: 40 LSPVDGRFLAKVASCDLADAEQAVKVARNAFDSGAWSRLAPAKRKQTMIRFADLLLENAE 99 Query: 90 EIATMECINNGKSIFEA-RLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLG 148 E+A +E ++ GK I ++ +D+ + L + A + E P G REP+G Sbjct: 100 ELALLETLDMGKPISDSLHIDVASAANSLRWSAEAIDKIYDEVAATPHAELGLVTREPVG 159 Query: 149 VCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNV 208 V I WN+P ++ WK PALA GN+++ KPS +P++A+ +A++ EAG+P G+FNV Sbjct: 160 VVAAIVPWNFPLLMSCWKLGPALATGNSVILKPSEKSPLTAIRIAQLAVEAGIPKGVFNV 219 Query: 209 VQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK-GIKPVTLELGGKSPLIIFSD 266 + G G G+ L H DV + FTGS ++M + + +K V LE GGKSP I+F+D Sbjct: 220 LPGYGHTVGKALALHMDVDTLVFTGSTKIAKQLMVYAGESNMKRVWLEAGGKSPNIVFAD 279 Query: 267 C-DMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDT 325 D+ A + A A QG+VC G+R+ V++ I DKF V++ + K G+PL +T Sbjct: 280 APDLKAAAEAAAGAIAFNQGEVCTAGSRLLVERSIKDKFLPLVIEALKGWKPGNPLDPET 339 Query: 326 RMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDM 385 +G L++ + VL +++ GAK++ GG + E G Y+ P + + M Sbjct: 340 NVGALVDTQQMNTVLSYIEAGHNDGAKLVAGGKRTLEE----TGGTYVEPTIFDGVTNAM 395 Query: 386 TCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFI 445 +EEIFGPV+S++ F+ E + ANDT +GLAA V+T ++ +AH L+AG+ ++ Sbjct: 396 KIAREEIFGPVLSVIEFEDAEEAVRIANDTPYGLAAAVWTSNLSKAHLTAKALRAGSVWV 455 Query: 446 NNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 487 N Y+ + PFGG+K+SG GR+ + Y++LK +++ Sbjct: 456 NQYDGGDMTAPFGGFKQSGNGRDKSLHAFDKYTELKATWIKL 497 >4LIH-A nrPDB Length = 504 Score = 282 bits (722), Expect = 2e-76, Method: Compositional matrix adjust. Identities = 175/472 (37%), Positives = 268/472 (56%), Gaps = 14/472 (2%) Query: 24 DASG--TEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFK--IWSQKSGMERCRILLE 79 DA G T P GRV+A GE +VN AV A+ AF +W+ + R +LL Sbjct: 38 DAHGGRTFDCVSPIDGRVLAKVADCGEADVNAAVAAARRAFDAGVWAGLNPRARKAVLLR 97 Query: 80 AARIIREREDEIATMECINNGKSIFEAR-LDIDISWQCLEYYAGLAASMAGEHIQLPGGS 138 A ++RE DE++ +E ++ GK I + +D+ + C+E++A + GE Sbjct: 98 WAALMREHLDELSLLETLDAGKPIGDTTTVDVPGAAYCVEWFAEAIDKVGGEVAPADHHL 157 Query: 139 FGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSE 198 G REP+GV + WN+P +A+WK PALA GN++V KPS +P++A+ +A++ E Sbjct: 158 VGLVTREPVGVVAAVVPWNFPILMAAWKFGPALAAGNSVVLKPSEKSPLTAIRVAQLAFE 217 Query: 199 AGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK-GIKPVTLELGG 257 AG+P G+FNVV G G+ L H DV ++FTGS G IM+ +A+ +K LELGG Sbjct: 218 AGIPAGVFNVVPGAGEPGKLLALHRDVDCIAFTGSTAVGKLIMQYAAQSNLKRAWLELGG 277 Query: 258 KSPLIIFSDC-DMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIK 316 KSP I+ DC D++ A + A A F G++C G+R+ V ++I D F E++V + Sbjct: 278 KSPNIVLPDCPDLDRAAQTAAGAIFYNMGEMCTAGSRLLVHRDIKDAFIEKLVAAARAYV 337 Query: 317 IGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPC 376 G+PL MG +++ LERVLG+++ + +G V G + G+Y+ P Sbjct: 338 PGNPLDPSVSMGAIVDGIQLERVLGYIEAGRGEGRLVTGGARVNAE-----TGGFYVEPT 392 Query: 377 VLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVA 436 V + D +EEIFGPV+S++ FD E + ANDT +GLAA V+T ++ AH V Sbjct: 393 VF-EVKPDAKIAREEIFGPVLSVIVFDDVDEAVRIANDTEYGLAAAVWTSNLTTAHDVSR 451 Query: 437 ELQAGTCFINNYNV-SPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 487 L+AGT ++N Y+ + PFGGYK+SG GR+ +E Y++LK+ + + Sbjct: 452 RLRAGTVWVNCYDEGGDMNFPFGGYKQSGNGRDKSLHALEKYTELKSTLIRL 503 >4F3X-A nrPDB Length = 498 Score = 281 bits (720), Expect = 4e-76, Method: Compositional matrix adjust. Identities = 162/479 (33%), Positives = 254/479 (53%), Gaps = 18/479 (3%) Query: 17 GARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRI 76 G+R E A E P TG I + +++ AV A+ AF WSQ + ER Sbjct: 31 GSRFE-AGTEAEEHILNPRTGAGIIDLAEASHAQIDAAVDAAERAFVGWSQTTPAERSNA 89 Query: 77 LLEAARIIREREDEIATMECINNGKSIFEARLD-IDISWQCLEYYAG----LAASMAGEH 131 LL+ A I + DE A +E +N GK I + D + C ++AG L A AGE+ Sbjct: 90 LLKIADAIEKEADEFAALEALNCGKPINAVKNDELPAIIDCWRFFAGAVRNLHAPAAGEY 149 Query: 132 IQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALL 191 LPG + RR+P+G+ I WNYP + +WK APA+ GN +VFKPS TP++AL Sbjct: 150 --LPGHT-SMIRRDPIGIVGSIAPWNYPLMMMAWKLAPAIGGGNTVVFKPSEQTPLTALK 206 Query: 192 LAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKP 250 LA + ++ +P G+ NV+ G G G L HP V VS TG + TG K++ +AK +K Sbjct: 207 LARLIADI-LPEGVVNVITGRGETVGNALINHPKVGMVSITGDIATGKKVLAAAAKTVKR 265 Query: 251 VTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVK 310 LELGGK+P+I++ D D+ V G + GQ C R++ + I +K ++ Sbjct: 266 THLELGGKAPVIVYGDADLEAVVNGIRTFGYYNAGQDCTAACRIYAEAGIYEKLVADLTS 325 Query: 311 QTQRIKIGDPLLEDTRMGPLINRPHLERVLGFV-KVAKEQGAKVLCGGDIYVPEDPKLKD 369 I+ + +GPLI+R +RV FV + A ++ ++ GG E Sbjct: 326 AVSTIRYNLDDDTENEIGPLISRRQRDRVASFVERAADQKHIEITTGGRTGSDE------ 379 Query: 370 GYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQ 429 G++ +P V+ + V+ E+FGPV+S+ F + + + AND+ +GLA+ V+T+DI Sbjct: 380 GFFFQPTVVAGATQEDEIVRREVFGPVVSVTRFTGKDDAVAWANDSDYGLASSVWTKDIS 439 Query: 430 RAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMG 488 +A R + LQ G +IN + + E+P GG K+SG+G++ +E Y+ ++ + + G Sbjct: 440 KAMRAASRLQYGCTWINTHFMLTNEMPHGGIKQSGYGKDMSVYALEDYTAVRHIMINHG 498 >2HG2-A nrPDB Length = 479 Score = 281 bits (719), Expect = 4e-76, Method: Compositional matrix adjust. Identities = 174/485 (35%), Positives = 260/485 (53%), Gaps = 20/485 (4%) Query: 6 FVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIW 65 ++ Q + +RG A ++ + PAT VI+ ++ A+ A+ A W Sbjct: 10 YIDGQFVTWRGDAWIDVVN---------PATEAVISRIPDGQAEDARKAIDAAERAQPEW 60 Query: 66 SQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAA 125 +ER L + + IRER EI+ + GK A +++ + ++Y A A Sbjct: 61 EALPAIERASWLRKISAGIRERASEISALIVEEGGKIQQLAEVEVAFTADYIDYMAEWAR 120 Query: 126 SMAGEHIQ--LPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSP 183 GE IQ PG + +R LGV GI WN+PF + + K APAL GN +V KPS Sbjct: 121 RYEGEIIQSDRPGENILLFKR-ALGVTTGILPWNFPFFLIARKMAPALLTGNTIVIKPSE 179 Query: 184 FTPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIME 242 FTP +A+ A+I E G+P G+FN+V G G GQ L +P VA VS TGSV G KIM Sbjct: 180 FTPNNAIAFAKIVDEIGLPRGVFNLVLGRGETVGQELAGNPKVAMVSMTGSVSAGEKIMA 239 Query: 243 MSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILD 302 +AK I V LELGGK+P I+ D D+ AVK + + + GQVC RV+VQK I D Sbjct: 240 TAAKNITKVCLELGGKAPAIVMDDADLELAVKAIVDSRVINSGQVCNCAERVYVQKGIYD 299 Query: 303 KFTEEVVKQTQRIKIGDPL-LEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYV 361 +F + + Q ++ G+P D MGPLIN LERV V A E+GA+V GG Sbjct: 300 QFVNRLGEAMQAVQFGNPAERNDIAMGPLINAAALERVEQKVARAVEEGARVAFGGKAVE 359 Query: 362 PEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAA 421 + GYY P +L + R +M+ + EE FGPV+ +++FDT + + AND+ +GL + Sbjct: 360 GK------GYYYPPTLLLDVRQEMSIMHEETFGPVLPVVAFDTLEDAISMANDSDYGLTS 413 Query: 422 GVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLK 481 ++T+++ A + + L+ G +IN N ++ G++KSG G +G+ + Y Q + Sbjct: 414 SIYTQNLNVAMKAIKGLKFGETYINRENFEAMQGFHAGWRKSGIGGADGKHGLHEYLQTQ 473 Query: 482 TVCVE 486 V ++ Sbjct: 474 VVYLQ 478 >3B4W-A nrPDB Length = 495 Score = 278 bits (711), Expect = 4e-75, Method: Compositional matrix adjust. Identities = 155/428 (36%), Positives = 240/428 (56%), Gaps = 12/428 (2%) Query: 65 WSQKSGMERCRILLEAARIIREREDEIATMECINNGK--SIFEARLDIDISWQCLEYYAG 122 W ER ++ A +++ ER+D + G+ +I E + S + Y+AG Sbjct: 64 WPSTPPHERAAVIAAAVKMLAERKDLFTKLLAAETGQPPTIIETMHWMG-SMGAMNYFAG 122 Query: 123 LAASMAGEHIQLPGGSFGYT--RREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFK 180 A + + GS+G + REP+GV I AWN P +A K APAL G +V K Sbjct: 123 AADKVTWTETRT--GSYGQSIVSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLK 180 Query: 181 PSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKI 240 P+ TP++A LAE+++E G+P G+ +VV GG TGQ L +PD+ +FTGS G ++ Sbjct: 181 PAAETPLTANALAEVFAEVGLPEGVLSVVPGGIETGQALTSNPDIDMFTFTGSSAVGREV 240 Query: 241 MEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEI 300 +A+ +KP TLELGGKS II D D+ A+ + + + GQ C N TR+ + Sbjct: 241 GRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVMNAGQGCVNQTRILAPRSR 300 Query: 301 LDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY 360 D+ V + +G P ++GPLI+ RV G++ E+GA+++CGG Sbjct: 301 YDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEKQRTRVEGYIAKGIEEGARLVCGGG-- 358 Query: 361 VPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA 420 PE L +G++++P V + + MT +EEIFGPV++I+ +DTE + + AND+ +GLA Sbjct: 359 RPEG--LDNGFFIQPTVFADVDNKMTIAQEEIFGPVLAIIPYDTEEDAIAIANDSVYGLA 416 Query: 421 AGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQL 480 V+T D+ + ++ +++ GT IN Y P PFGGYK SG GRENG +E+++Q Sbjct: 417 GSVWTTDVPKGIKISQQIRTGTYGINWYAFDPGS-PFGGYKNSGIGRENGPEGVEHFTQQ 475 Query: 481 KTVCVEMG 488 K+V + MG Sbjct: 476 KSVLLPMG 483 >4YWE-A nrPDB Length = 487 Score = 274 bits (701), Expect = 6e-74, Method: Compositional matrix adjust. Identities = 160/426 (37%), Positives = 231/426 (54%), Gaps = 6/426 (1%) Query: 65 WSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLA 124 W S ER R+L+ + + + +E+A +E + GK + +AR D + E+YAG A Sbjct: 66 WGAASAAERGRVLMRLSARVTDSIEELAAIEARDTGKPLKQARADAAALARYFEFYAGAA 125 Query: 125 ASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPF 184 + GE + G T REP GV I WNYP QI ALA GNA V KP+ Sbjct: 126 DKLHGETLPYQAGYTVLTVREPHGVTGHIVPWNYPMQIFGRSVGAALAAGNACVVKPAED 185 Query: 185 TPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEM 243 +S L +AE+ +EAG+P G N+V G G G L +HP + +SFTGS TG + +M Sbjct: 186 ACLSVLRVAELAAEAGLPAGALNIVTGYGHEAGAALARHPGIDHISFTGSPATGKLVTQM 245 Query: 244 SAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDK 303 +A+ PVTLELGGKSP I+F+D D++ A+ + A GQ C G+RV +++ + + Sbjct: 246 AAENHVPVTLELGGKSPQIVFADADLDAALPVLVSAIVQNGGQTCSAGSRVLIERAVYEP 305 Query: 304 FTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPE 363 E + +++G P D GPLIN +RV F+ A+ G + G + V + Sbjct: 306 LVERLATAFNGLRVG-PSRADLDCGPLINAKQQQRVWDFLSDAQHDGIPMAAHGQV-VAD 363 Query: 364 DPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGV 423 P + G+Y P +L + +EE+FGPV++ + F E E + AN T +GL AG+ Sbjct: 364 AP--ESGFYQAPALLRDVPPSHRLAQEEVFGPVLAAMRFVDEDEAVALANGTPYGLVAGI 421 Query: 424 FTRDIQRAHRVVAELQAGTCFINNYNV-SPVELPFGGYKKSGFGRENGRVTIEYYSQLKT 482 +TRD R R+ L+AG FINNY VELPFGG SG GRE G + ++ LKT Sbjct: 422 WTRDGARQMRLARRLRAGQVFINNYGAGGGVELPFGGVGHSGHGREKGFEALYGFTALKT 481 Query: 483 VCVEMG 488 + + G Sbjct: 482 IAIRHG 487 >3EK1-A nrPDB Length = 504 Score = 270 bits (690), Expect = 1e-72, Method: Compositional matrix adjust. Identities = 166/470 (35%), Positives = 251/470 (53%), Gaps = 11/470 (2%) Query: 17 GARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRI 76 G ++ AD + T K PA G VI T + A+ + A W+ K+ ER I Sbjct: 39 GRWIDAADGT-TIKVTNPADGSVIGTVPSLSVATIKEAIDASAKALSGWAAKTAKERAGI 97 Query: 77 LLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLP- 135 L + +I D+IA + GK + EAR ++ + +E++A A + G+ I P Sbjct: 98 LRKWFDLIIANADDIALIMTSEQGKPLAEARGEVLYAASFIEWFAEEAKRVYGDTIPAPQ 157 Query: 136 GGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEI 195 G R+P+GV I WN+P + + K+APALA G M+ +P+ TP++AL L + Sbjct: 158 NGQRLTVIRQPVGVTAAITPWNFPAAMITRKAAPALAAGCTMIVRPADLTPLTALALGVL 217 Query: 196 YSEAGVPPGLFNVVQGGA-ATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLE 254 +AG+P G+ +V G A G L + V K+SFTGS G +M A IK ++LE Sbjct: 218 AEKAGIPAGVLQIVTGKAREIGAELTSNDTVRKLSFTGSTEVGRLLMAQCAPTIKRISLE 277 Query: 255 LGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQR 314 LGG +P I+F D D++ AV GA+++ + GQ C R++VQ+ + DKF E++ + + Sbjct: 278 LGGNAPFIVFDDADLDAAVDGAMVSKYRNAGQTCVCANRIYVQRGVYDKFAEKLAAKVKE 337 Query: 315 IKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMR 374 +K+G+ +GP+I + +V ++ A +GAK++ GG K G + Sbjct: 338 LKVGNGTEPGVVIGPMIEEKAITKVKAHIEDAVSKGAKLITGG--------KELGGLFFE 389 Query: 375 PCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRV 434 P +LT DM KEE FGP+ + +FDTE EV+ +ANDT FGLAA +T + RA RV Sbjct: 390 PGILTGVTSDMLVAKEETFGPLAPLFAFDTEEEVIAQANDTIFGLAAYFYTENFSRAIRV 449 Query: 435 VAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVC 484 L+ G N +S PFGG K+SG GRE + IE Y + K +C Sbjct: 450 SEALEYGMVGHNTGLISNEVAPFGGVKQSGLGREGSKYGIEEYLETKYIC 499 >4JZ6-A nrPDB Length = 500 Score = 267 bits (683), Expect = 6e-72, Method: Compositional matrix adjust. Identities = 158/471 (33%), Positives = 248/471 (52%), Gaps = 19/471 (4%) Query: 26 SGTEKAFE---PATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAAR 82 S ++ FE P + V+ + + A Q A+ AFK W ER R+LL+ A Sbjct: 31 SSDQQTFERKHPVSSEVMTESANATVTDAIKAAQAAEEAFKTWKDVGPSERRRLLLKVAD 90 Query: 83 IIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGG-SFGY 141 ++ + + + + G S A ++ S A LA + GE I + Sbjct: 91 VMESKTPKFIEVMAMEVGASALWAGFNVHASANVFREAASLATQIQGETIPTDKAETLSM 150 Query: 142 TRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGV 201 T R+P+G + I WN +A+ A L CGN +VFK S F+P + L+ + EAG+ Sbjct: 151 TLRQPVGPILSIVPWNGTAVLAARAIAYPLVCGNTVVFKGSEFSPATHALITQCVQEAGL 210 Query: 202 PPGLFNVVQGGA----ATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGG 257 P G+ N + L ++ +++FTGS G I + +A+ +K LELGG Sbjct: 211 PAGVLNYLNSSPDRSPEIADALISAKEIRRINFTGSTRVGSIIAQKAAQHLKRCLLELGG 270 Query: 258 KSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKI 317 KSPLI+ D D+N AVK A+ +FL QGQ+C + R+ V ++I D+F V++T+R+ + Sbjct: 271 KSPLIVLDDADINAAVKAAVFGSFLFQGQICMSTERLVVDEKIADEFVARFVEKTERLSV 330 Query: 318 GDPLLE-DTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPC 376 GDP L D +GP+++ ER+ G K A ++GAKV+CGG + G M Sbjct: 331 GDPCLTGDCIIGPMVSPNSGERINGLFKDAIDKGAKVVCGG---------MAQGAVMPAT 381 Query: 377 VLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVA 436 +L + + DM EE FGP+ ++ EAE + AND+ +GL++GVF RDI RA RV Sbjct: 382 ILDHVKSDMRIYDEETFGPITVVIRCKGEAEAIRIANDSVYGLSSGVFGRDINRALRVGM 441 Query: 437 ELQAGTCFINNYNV-SPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 486 ++ G IN V + + P+GG K +G+GR +GR I+ +++LK + +E Sbjct: 442 SIEYGCVHINGSTVQNEAQAPYGGTKNTGYGRFDGRAVIDEFTELKWLTIE 492 >5J77-A nrPDB Length = 508 Score = 266 bits (681), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 151/491 (30%), Positives = 254/491 (51%), Gaps = 20/491 (4%) Query: 1 MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA 60 M T ++ Q +N G V+ + P TG+VI + +V+ A+ A+ Sbjct: 1 MDTKLYIDGQWVNSSSGKTVD---------KYSPVTGQVIGRMEAATRDDVDRAIDAAED 51 Query: 61 AFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYY 120 AF W+ +ER +I+ A +I + E+ + NGK + EA+ ++D ++YY Sbjct: 52 AFWAWNDLGSVERSKIIYRAKELIEKNRAELENIIMEENGKPVKEAKEEVDGVIDQIQYY 111 Query: 121 AGLAASMAGEHIQLPGGSFGYTR----REPLGVCVGIGAWNYPFQIASWKSAPALACGNA 176 A A + GE ++ G+ + + + P G+ V + WN+P + + K APAL GN Sbjct: 112 AEWARKLNGEVVE---GTSSHRKIFQYKVPYGIVVALTPWNFPAGMVARKLAPALLTGNT 168 Query: 177 MVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVP 235 +V KPS TP SA + + EAGVP G+ N + G G+ G ++ +H V ++ TGS Sbjct: 169 VVLKPSSDTPGSAEWIVRKFVEAGVPKGVLNFITGRGSEIGDYIVEHKKVNLITMTGSTA 228 Query: 236 TGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVF 295 TG +IM+ ++ + + LELGGK+P +++ D DM+NA+K L A + GQ C R++ Sbjct: 229 TGQRIMQKASANMAKLILELGGKAPFMVWKDADMDNALKTLLWAKYWNAGQSCIAAERLY 288 Query: 296 VQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLC 355 V ++I D F V+ ++++ +GDP ++ MGPLIN+ L+ V+ AKE GAK+L Sbjct: 289 VHEDIYDTFMSRFVELSRKLALGDP--KNADMGPLINKGALQATSEIVEEAKESGAKILF 346 Query: 356 GGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDT 415 GG P ++GY+ P ++ N +EEIF PV+ + E+ + AND Sbjct: 347 GGSQPSLSGP-YRNGYFFLPTIIGNADQKSKIFQEEIFAPVIGARKISSVEEMYDLANDN 405 Query: 416 TFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIE 475 +GLA+ +FT+D ++ G ++N + G++ +G E + I Sbjct: 406 KYGLASYLFTKDPNIIFEASERIRFGELYVNMPGPEASQGYHTGFRMTGQAGEGSKYGIS 465 Query: 476 YYSQLKTVCVE 486 Y +LK + V+ Sbjct: 466 EYLKLKNIYVD 476 >3K2W-A nrPDB Length = 497 Score = 266 bits (679), Expect = 2e-71, Method: Compositional matrix adjust. Identities = 160/478 (33%), Positives = 259/478 (54%), Gaps = 9/478 (1%) Query: 12 LNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGM 71 +N+ GG V P++ S T P+TG+VI + + A++ A+AA K W++ + Sbjct: 14 VNFIGGQYV-PSNESDTIDILSPSTGKVIGEIPAGCKADAENALEVAQAAQKAWAKLTAR 72 Query: 72 ERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEH 131 R +L A IRE + +A M GK + A +++D++ ++Y A ++ G+ Sbjct: 73 TRQNMLRTFANKIRENKHILAPMLVAEQGKLLSVAEMEVDVTATFIDYGCDNALTIEGD- 131 Query: 132 IQLPGGSFG---YTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVS 188 LP + Y + P GV VGI AWN+P +A K PAL GN MV KP+ TP++ Sbjct: 132 -ILPSDNQDEKIYIHKVPRGVVVGITAWNFPLALAGRKIGPALITGNTMVLKPTQETPLA 190 Query: 189 ALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKG 247 L I EAG+P G+ NV+ G G+ GQ LC+ P ++ TGS G +I + SA+ Sbjct: 191 TTELGRIAKEAGLPDGVLNVINGTGSVVGQTLCESPITKMITMTGSTVAGKQIYKTSAEY 250 Query: 248 IKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEE 307 + PV LELGGK+P+++ D D++ A + AL F GQVC R++V + D+F + Sbjct: 251 MTPVMLELGGKAPMVVMDDADLDKAAEDALWGRFANCGQVCTCVERLYVHASVYDEFMAK 310 Query: 308 VVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKL 367 + + +K+GDP+ D++MGP N+ ++ + V A +QGA V GG E Sbjct: 311 FLPLVKGLKVGDPMDADSQMGPKCNQREIDNIDHIVHEAIKQGATVATGGKTATVE--GF 368 Query: 368 KDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRD 427 + G + P VL + + D V EE FGP++ I+ + + +E ND+ +GL+A V T+ Sbjct: 369 EGGCWYEPTVLVDVKQDNIVVHEETFGPILPIVKVSSMEQAIEFCNDSIYGLSAYVHTQS 428 Query: 428 IQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCV 485 ++ +++L+ G +IN + G+K+SGFG E+G+ +E Y + KTV + Sbjct: 429 FANINQAISDLEVGEVYINRGMGEQHQGFHNGWKQSGFGGEDGKFGLEQYLEKKTVYI 486 >5EUY-A nrPDB Length = 491 Score = 255 bits (652), Expect = 3e-68, Method: Compositional matrix adjust. Identities = 152/479 (31%), Positives = 243/479 (50%), Gaps = 14/479 (2%) Query: 13 NYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGME 72 NY G EP+ + K P G IA SG ++ A+ +A A K W+ + Sbjct: 11 NYINGEFKEPSTGAFQVKT-SPVDGSKIAEVPRSGREDAREAIDSAFEALKAWANIPAIR 69 Query: 73 RCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHI 132 R L + + R+ +++ + + G + + ++ + + ++ A LA G + Sbjct: 70 RAEYLYKMLEVFRQMKEDFMKILTVEGGGTYRKVWGEVVFTERLIQNAAELARHYQGRVL 129 Query: 133 QLPGGS-FGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALL 191 Q S + GV I WNYP I+ K A LA GN +V+KP+ TPV+ L Sbjct: 130 QSDSESTISVVFKRSKGVVGVITPWNYPLSISMKKIAHTLAVGNTVVYKPASDTPVTGWL 189 Query: 192 LAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKP 250 +A++ ++AG+P G+FN+V G G G+ + H VA V+FTG TG +I +A +K Sbjct: 190 IAQMVAKAGLPKGVFNLVIGPGPVVGEEIVTHKRVAHVTFTGESSTGREIAAKAAGTLKT 249 Query: 251 VTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVK 310 VTLELGG PLII D D++ A + A+ A+ QGQ+C + R+ V K + DKF E V Sbjct: 250 VTLELGGSDPLIILDDVDVDYAARLAVFASLFHQGQICTSAKRIIVHKAVADKFIERYVH 309 Query: 311 QTQRIKIGDPLL-EDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKD 369 + ++I DP E +GPLIN + + FV A +G ++L GG + Sbjct: 310 YVKMLRIDDPRKDEKVDLGPLINERQVALMKEFVDDAVSRGGRLLIGGRSW--------- 360 Query: 370 GYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQ 429 G + P + + + ++EE+FGPV I+ + + + +E ANDT +GL+ V T ++ Sbjct: 361 GNFFEPAIFVDVDRNFRIMREEVFGPVRPIVVVENDDQAVEVANDTDYGLSGAVLTNNVN 420 Query: 430 RAHRVVAELQAGTCFINNYN-VSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 487 RA R+ +++G IN+ + +PFGG K SG GRE G + + + V V + Sbjct: 421 RAFRIAEAVESGMFHINDVTFLEESHVPFGGIKASGVGREGGEWSFHETTYDRWVTVTL 479 >5VBF-A nrPDB Length = 478 Score = 253 bits (647), Expect = 9e-68, Method: Compositional matrix adjust. Identities = 162/476 (34%), Positives = 244/476 (51%), Gaps = 10/476 (2%) Query: 11 PLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSG 70 PL R AD T+ +P T RV+ + +++ AVQ A AF W +S Sbjct: 6 PLRLYIDGRFHDADGRRTQPVVDPGTTRVLGELPHATAHDIDAAVQAAHRAFVTWRHESP 65 Query: 71 MERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGE 130 + R +L AA + RER + I ++ GK + EA ++ + + LE++A G Sbjct: 66 LVRSDLLRRAAALARERAETIGRHITMDQGKPLREAIAEVVSAAEQLEWHAEEGRRTYGR 125 Query: 131 HIQLPGGSFGYT-RREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSA 189 + T REP+GVC WN+PF A K A ALA G +V K +P + Sbjct: 126 VVPARSPDVMQTVLREPIGVCAAFSPWNFPFSQAMHKIAAALASGCTLVLKGPEESPSAI 185 Query: 190 LLLAEIYSEAGVPPGLFNVVQG--GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKG 247 + LA+++ +AG+PPG N+V G G + Q L + P V K+SFTGSVP G ++ ++A Sbjct: 186 VALAQLFHDAGLPPGCLNIVWGVPGDVSKQ-LIEAPQVRKISFTGSVPVGKQLAALAASL 244 Query: 248 IKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEE 307 +K +T+ELGG +P+++ +D D+ A F GQVC + TR FVQ+ D+F Sbjct: 245 MKRMTMELGGHAPVLVCADADVERAAAMLAAYKFRNAGQVCVSPTRFFVQRAAFDRFVCA 304 Query: 308 VVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKL 367 + I++G L MGPL + ++ + FV A +GA++ GG + +P Sbjct: 305 YLDAVGTIRVGYGLDAGVTMGPLAHARRVDEIDAFVADATAKGAQIATGG-MRLP----- 358 Query: 368 KDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRD 427 G+Y P V+ D + +E FGP++ I+ FD + L AN FGLA+ FT Sbjct: 359 GPGHYFAPTVVLGPTRDTRLMNDEPFGPIVGIVPFDDLDDALAEANRLPFGLASYAFTTS 418 Query: 428 IQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTV 483 + AHR+ L+AG IN++ + P E+PFGG K SGFG E G + Y K V Sbjct: 419 ARNAHRISRALEAGMVNINHFGMGPAEIPFGGVKDSGFGSEGGMEAFDGYLVTKFV 474 >2W8P-A nrPDB Length = 487 Score = 249 bits (637), Expect = 1e-66, Method: Compositional matrix adjust. Identities = 163/474 (34%), Positives = 253/474 (53%), Gaps = 14/474 (2%) Query: 17 GARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRI 76 G R PA A T +PA+G + G +E AV+ A AF W + S ER + Sbjct: 18 GGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSL 75 Query: 77 LLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPG 136 L + ++ + +D++A + +GK + EA +I S LE+++ A + G+ I P Sbjct: 76 LRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPA 135 Query: 137 GSF-GYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEI 195 ++P+GV I WN+P + + K ALA G +V KP+ TP SAL LAE+ Sbjct: 136 KDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAEL 195 Query: 196 YSEAGVPPGLFNVV----QGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPV 251 S+AG+P G++NV+ + G+ +C P V+K+SFTGS TG ++ +A +K V Sbjct: 196 ASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRV 255 Query: 252 TLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQ 311 ++ELGG +P I+F +++ AV GA+ + F GQ + VQ+ I D F + + Sbjct: 256 SMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTAVCSNQFLVQRGIHDAFVKAFAEA 315 Query: 312 TQR-IKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDG 370 ++ +++G+ E T GPLIN +E+V V A +GA V+ GG + +L Sbjct: 316 MKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRH-----QLGKN 370 Query: 371 YYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQR 430 ++ P +L N DM C EE FGP+ ++ FDTE E + AN GLA +++D + Sbjct: 371 FF-EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQ 429 Query: 431 AHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVC 484 RV +L+ G +N +S VE PFGG K+SG GRE + I+ Y +LK VC Sbjct: 430 IWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 483 >5X5U-A nrPDB Length = 505 Score = 246 bits (627), Expect = 2e-65, Method: Compositional matrix adjust. Identities = 157/466 (33%), Positives = 232/466 (49%), Gaps = 13/466 (2%) Query: 25 ASG-TEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARI 83 ASG T PATG+ I +G +++ A+ A++ F+ W + ER + +AA + Sbjct: 45 ASGKTIDVVNPATGKPIGRVAHAGIADLDRALAAAQSGFEAWRKVPAHERAATMRKAAAL 104 Query: 84 IREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTR 143 +RER D IA + GK + EAR+++ + +E++A + G + P + G + Sbjct: 105 VRERADAIAQLMTQEQGKPLTEARVEVLSAADIIEWFADEGRRVYGRIV--PPRNLGAQQ 162 Query: 144 ---REPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAG 200 +EP+G WN+P K + ALA G + + K TP S L + +AG Sbjct: 163 TVVKEPVGPVAAFTPWNFPVNQVVRKLSAALATGCSFLVKAPEETPASPAALLRAFVDAG 222 Query: 201 VPPGLFNVVQGGAA-TGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKS 259 VP G+ +V G A +L HP + KV+FTGS P G ++ ++ +K T+ELGG + Sbjct: 223 VPAGVIGLVYGDPAEISSYLIPHPVIRKVTFTGSTPVGKQLASLAGLHMKRATMELGGHA 282 Query: 260 PLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGD 319 P+I+ D D+ AVK A A F GQVC + TR V I D+FT +VK + +K+G+ Sbjct: 283 PVIVAEDADVALAVKAAGGAKFRNAGQVCISPTRFLVHNSIRDEFTRALVKHAEGLKVGN 342 Query: 320 PLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLT 379 L E T +G L N L + + A++ GA + GG+ E G + P V+ Sbjct: 343 GLEEGTTLGALANPRRLTAMASVIDNARKVGASIETGGERIGSE------GNFFAPTVIA 396 Query: 380 NCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQ 439 N D E FGPV +I FD E + AN FGLA FTR H + L+ Sbjct: 397 NVPLDADVFNNEPFGPVAAIRGFDKLEEAIAEANRLPFGLAGYAFTRSFANVHLLTQRLE 456 Query: 440 AGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCV 485 G +IN E+PFGG K SG+G E G +E Y K+V V Sbjct: 457 VGMLWINQPATPWPEMPFGGVKDSGYGSEGGPEALEPYLVTKSVTV 502 >3RHD-A nrPDB Length = 486 Score = 243 bits (619), Expect = 2e-64, Method: Compositional matrix adjust. Identities = 153/461 (33%), Positives = 246/461 (53%), Gaps = 26/461 (5%) Query: 34 PATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIAT 93 P + VI +E A+ A+ ++ +R IL+ A+ I+E+++E+A Sbjct: 19 PYSLEVIKKIPALSREEAKEAIDTAEKYKEVMKNLPITKRYNILMNIAKQIKEKKEELAK 78 Query: 94 MECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQ--LPGGS-FGYTRREPLGVC 150 + I+ GK I +AR++++ S + LAA EH +P +TRREP+G+ Sbjct: 79 ILAIDAGKPIKQARVEVERSIGTFK----LAAFYVKEHRDEVIPSDDRLIFTRREPVGIV 134 Query: 151 VGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEA----GVPPGLF 206 I +N+P +++ K APA+A GN +V PS P+ + LA+I A VP G++ Sbjct: 135 GAITPFNFPLNLSAHKIAPAIATGNVIVHHPSSKAPLVCIELAKIIENALKKYNVPLGVY 194 Query: 207 NVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFS 265 N++ G G G + + V +SFTGS G I + + G K + LELGG +P I+ Sbjct: 195 NLLTGAGEVVGDEIVVNEKVNMISFTGSSKVGELITKKA--GFKKIALELGGVNPNIVLK 252 Query: 266 DCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDT 325 D D+N AV + +F+ GQVC + + V + I DKF E V + + + +G+PL E T Sbjct: 253 DADLNKAVNALIKGSFIYAGQVCISVGMILVDESIADKFIEMFVNKAKVLNVGNPLDEKT 312 Query: 326 RMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDM 385 +GPLI+ H E V V+ A ++G K+L GG +D P +L RD++ Sbjct: 313 DVGPLISVEHAEWVEKVVEKAIDEGGKLLLGGK---------RDKALFYPTILEVDRDNI 363 Query: 386 TCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFI 445 C K E F PV+ I+ + E E+++ AN T +GL + +FT DI ++ + L+ G I Sbjct: 364 LC-KTETFAPVIPIIRTNEE-EMIDIANSTEYGLHSAIFTNDINKSLKFAENLEFGGVVI 421 Query: 446 NNYNVSPVE-LPFGGYKKSGFGRENGRVTIEYYSQLKTVCV 485 N+ ++ + +PFGG KKSG GRE + +E S +KT+ + Sbjct: 422 NDSSLFRQDNMPFGGVKKSGLGREGVKYAMEEMSNIKTIII 462 >3EFV-A nrPDB Length = 462 Score = 241 bits (616), Expect = 4e-64, Method: Compositional matrix adjust. Identities = 147/452 (32%), Positives = 222/452 (49%), Gaps = 10/452 (2%) Query: 34 PATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIAT 93 PATG+ +A + +E+ A+ A + FK W S +R + L + + +R +E+A Sbjct: 14 PATGQTLAAMPWANAQEIEHALSLAASGFKKWKMTSVAQRAQTLRDIGQALRAHAEEMA- 72 Query: 94 MECINN--GKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCV 151 +CI GK I +AR ++ S ++YA +M L PLGV + Sbjct: 73 -QCITREMGKPIKQARAEVTKSAALCDWYAEHGPAMLNPEPTLVENQQAVIEYRPLGVIL 131 Query: 152 GIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG 211 I WN+P + P L GN+ + K +P A ++A I +EAG P G++ V Sbjct: 132 AIMPWNFPLWQVLRGAVPILLAGNSYLLKHAPNVTGCAQMIARILAEAGTPAGVYGWVNA 191 Query: 212 GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNN 271 + P +A V+ TGSV G I + +K LELGG P I+ +D D+ Sbjct: 192 NNEGVSQMINDPRIAAVTVTGSVRAGAAIGAQAGAALKKCVLELGGSDPFIVLNDADLEL 251 Query: 272 AVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLI 331 AVK A+ + GQVC R V++ I FT+ V +K+GDPL+E+ +GP+ Sbjct: 252 AVKAAVAGRYQNTGQVCAAAKRFIVEEGIAQAFTDRFVAAAAALKMGDPLVEENDLGPMA 311 Query: 332 NRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEE 391 + + V+ + +GA++L GG+ E G Y VL + DMT ++E Sbjct: 312 RFDLRDELHQQVQASVAEGARLLLGGEKIAGE------GNYYAATVLADVTPDMTAFRQE 365 Query: 392 IFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVS 451 +FGPV +I A L AND+ FGL+A +FT D A + A L+ G FIN Y+ S Sbjct: 366 LFGPVAAITVAKDAAHALALANDSEFGLSATIFTADDTLAAEMAARLECGGVFINGYSAS 425 Query: 452 PVELPFGGYKKSGFGRENGRVTIEYYSQLKTV 483 + FGG KKSGFGRE + + ++TV Sbjct: 426 DARVAFGGVKKSGFGRELSHFGLHEFCNVQTV 457 >1T90-A nrPDB Length = 486 Score = 241 bits (614), Expect = 7e-64, Method: Compositional matrix adjust. Identities = 144/476 (30%), Positives = 246/476 (51%), Gaps = 10/476 (2%) Query: 13 NYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGME 72 NY G VE + E PAT V+ S +++++ A Q A AFK WS+ + Sbjct: 8 NYINGEWVE-SKTDQYEDVVNPATKEVLCQVPISTKEDIDYAAQTAAEAFKTWSKVAVPR 66 Query: 73 RCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHI 132 R RIL +++ + ++E+A + I NGK+ EA ++ + +E+ AG + M G+ + Sbjct: 67 RARILFNFQQLLSQHKEELAHLITIENGKNTKEALGEVGRGIENVEFAAGAPSLMMGDSL 126 Query: 133 -QLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALL 191 + R P+GV GI +N+P + W A+A GN + KPS TP+ Sbjct: 127 ASIATDVEAANYRYPIGVVGGIAPFNFPMMVPCWMFPMAIALGNTFILKPSERTPLLTEK 186 Query: 192 LAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPV 251 L E++ +AG+P G+FNVV G + +HP++ +SF GS P G + + ++ +K V Sbjct: 187 LVELFEKAGLPKGVFNVVYGAHDVVNGILEHPEIKAISFVGSKPVGEYVYKKGSENLKRV 246 Query: 252 TLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQ 311 G K+ I+ +D ++ + V + A F + G+ C V V++ I D+F ++ ++ Sbjct: 247 QSLTGAKNHTIVLNDANLEDTVTNIVGAAFGSAGERCMACAVVTVEEGIADEFMAKLQEK 306 Query: 312 TQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGY 371 IKIG+ L + +GP+I + +R L +++ E+GA+++C G V + DGY Sbjct: 307 VADIKIGNGLDDGVFLGPVIREDNKKRTLSYIEKGLEEGARLVCDGRENVSD-----DGY 361 Query: 372 YMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRA 431 ++ P + N +MT K+EIF PV+S++ E +E AN + F A +FT + Sbjct: 362 FVGPTIFDNVTTEMTIWKDEIFAPVLSVIRVKNLKEAIEIANKSEFANGACLFTSNSNAI 421 Query: 432 HRVVAELQAGTCFINNYNVSPVE-LPFGGYKKSGFG--RENGRVTIEYYSQLKTVC 484 + AG IN +P+ PF G+K S FG NG+ ++++Y++ K V Sbjct: 422 RYFRENIDAGMLGINLGVPAPMAFFPFSGWKSSFFGTLHANGKDSVDFYTRKKVVT 477 >3R64-A nrPDB Length = 508 Score = 241 bits (614), Expect = 8e-64, Method: Compositional matrix adjust. Identities = 156/460 (33%), Positives = 240/460 (52%), Gaps = 17/460 (3%) Query: 34 PATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIAT 93 P VIA + +V+ A + AK A W+ ER I+ AA ++ E +EI Sbjct: 35 PYDDSVIAESKQASIADVDAAYEAAKKAQAEWAATPAAERSAIIYRAAELLEEHREEIVE 94 Query: 94 MECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGE--HIQLPGGSFGYTRREPLGVCV 151 +G + +A L+I ++ + A + G PG R GV Sbjct: 95 WLIKESGSTRSKANLEITLAGNITKESASFPGRVHGRISPSNTPGKE-NRVYRVAKGVVG 153 Query: 152 GIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSA-LLLAEIYSEAGVPPGLFNVVQ 210 I WN+P ++ APALA GNA+V KP+ TPV+ ++ A I+ EAGVP G+ + V Sbjct: 154 VISPWNFPLNLSIRSVAPALAVGNAVVIKPASDTPVTGGVIPARIFEEAGVPAGVISTVA 213 Query: 211 G-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKG--IKPVTLELGGKSPLIIFSDC 267 G G+ G H +SFTGS P G ++ E++ G +K V LELGG +P ++ +D Sbjct: 214 GAGSEIGDHFVTHAVPKLISFTGSTPVGRRVGELAINGGPMKTVALELGGNAPFVVLADA 273 Query: 268 DMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRM 327 D++ A + A + FL QGQ+C + RV V + D+F E+ V+ + I GDP E T + Sbjct: 274 DIDAAAQAAAVGAFLHQGQICMSINRVIVDAAVHDEFLEKFVEAVKNIPTGDPSAEGTLV 333 Query: 328 GPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTC 387 GP+IN L + +++AK++GA V G I +G + P V ++ DM Sbjct: 334 GPVINDSQLSGLKEKIELAKKEGATVQVEGPI---------EGRLVHPHVFSDVTSDMEI 384 Query: 388 VKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN 447 +EEIFGP++S+L D EA E AN + FGL+A V+++DI RA + ++ +G IN+ Sbjct: 385 AREEIFGPLISVLKADDEAHAAELANASDFGLSAAVWSKDIDRAAQFALQIDSGMVHIND 444 Query: 448 YNVSPV-ELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 486 V+ + FGG K SG GR NG IE ++ + + ++ Sbjct: 445 LTVNDEPHVMFGGSKNSGLGRFNGDWAIEEFTTDRWIGIK 484 >3RH9-A nrPDB Length = 506 Score = 235 bits (599), Expect = 4e-62, Method: Compositional matrix adjust. Identities = 153/470 (32%), Positives = 250/470 (53%), Gaps = 9/470 (1%) Query: 17 GARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRI 76 G R + + T + PATG VIA E++V AV+ ++A ++ + +E R Sbjct: 17 GGRWKDSAGGATFDVYNPATGSVIAKVPSMPEEDVVAAVEAGQSALRL-TNPWPIETRRK 75 Query: 77 LLEAARI-IREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHI-QL 134 LE R ++E +EI + C+ +GK EA+ ++D + +Y A +++ I + Sbjct: 76 WLEDIRDGLKENREEIGRILCMEHGKPWKEAQGEVDYAAGFFDYCAKHISALDSHTIPEK 135 Query: 135 PGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAE 194 P P+GV I WN+P + + K + ALA G V KP+ TP++ + Sbjct: 136 PKDCTWTVHYRPVGVTGLIVPWNFPIGMIAKKLSAALAAGCPSVIKPASETPLTMIAFFS 195 Query: 195 IYSEAGVPPGLFNVVQGGAAT-GQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTL 253 + + +P G+ N+V G A+ G+ LC+H DV +SFTGS G K++ +A+ +K + L Sbjct: 196 VMDKLDLPDGMVNLVMGKASVIGKVLCEHKDVPMLSFTGSTEVGRKLIVDTAEQVKKLAL 255 Query: 254 ELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQ 313 ELGG +P I+F D D+ A + F GQ C R+FV +++ D F +++ ++ Sbjct: 256 ELGGNAPFIVFDDADLEAAADNLIANKFRGGGQTCVCANRIFVHEKVADAFGQKLAERVN 315 Query: 314 RIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYM 373 ++ +GD + + +GPLIN+ ++V ++ A ++GA ++ G + +L DG + Sbjct: 316 KMTVGDGMNDGIDIGPLINKQGFDKVKRHLQDALDKGASLVAG-----KQPAELGDGLFF 370 Query: 374 RPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHR 433 P V+ +M C +EE FGP++ + F TE EV++ NDT FGLA+ VFT D +RA R Sbjct: 371 PPTVVQGVDREMCCYQEETFGPLVPMALFRTEEEVIDAGNDTEFGLASYVFTADAERAQR 430 Query: 434 VVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTV 483 V A L+ G N E PFGG K SG GRE G + + + +TV Sbjct: 431 VAAGLRFGHVGWNTGTGPTPEAPFGGMKASGIGREGGLEGLFEFVEAQTV 480 >2QE0-A nrPDB Length = 475 Score = 234 bits (596), Expect = 8e-62, Method: Compositional matrix adjust. Identities = 147/468 (31%), Positives = 235/468 (50%), Gaps = 24/468 (5%) Query: 30 KAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIRERED 89 K +EPA+G + + +EV+ +AK A W S +ER L + A I+ ++ Sbjct: 21 KIYEPASGAELGSVPAMSTEEVDYVYASAKKAQPAWRALSYIERAAYLHKVADILMRDKE 80 Query: 90 EIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSF--------GY 141 +I + K A ++ + + + Y A M GE ++ GGSF Sbjct: 81 KIGAILSKEVAKGYKSAVSEVVRTAEIINYAAEEGLRMEGEVLE--GGSFEAASKKKIAV 138 Query: 142 TRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGV 201 RREP+G+ + I +NYP +A K APAL GN + FKP +S LLLAE ++EAG+ Sbjct: 139 VRREPVGLVLAISPFNYPVNLAGSKIAPALIAGNVIAFKPPTQGSISGLLLAEAFAEAGL 198 Query: 202 PPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSP 260 P G+FN + G G+ G ++ +H V ++FTGS G +I +M+ G++P+ L LGGK Sbjct: 199 PAGVFNTITGRGSEIGDYIVEHQAVNFINFTGSTGIGERIGKMA--GMRPIMLALGGKDS 256 Query: 261 LIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDP 320 I+ D D+ K + F GQ C RV V + + D+ E++ ++ + IG+P Sbjct: 257 AIVLEDADLELTAKNIIAGAFGYSGQRCTAVKRVLVMESVADELVEKIREKVLALTIGNP 316 Query: 321 LLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTN 380 +D + PLI+ + V G + A ++GA L ++G + P + Sbjct: 317 -EDDADITPLIDTKSADYVEGLINDANDKGATALT---------EIKREGNLICPILFDK 366 Query: 381 CRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQA 440 DM EE FGPV+ I+ + E +E +N + +GL A +FT D RA + +L+ Sbjct: 367 VTTDMRLAWEEPFGPVLPIIRVTSVEEAIEISNKSEYGLQASIFTNDFPRAFGIAEQLEV 426 Query: 441 GTCFINNYNVSPVE-LPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 487 GT INN + PF G KKSG G + + +IE + +K+V ++ Sbjct: 427 GTVHINNKTQRGTDNFPFLGAKKSGAGIQGVKYSIEAMTTVKSVVFDI 474 >3I44-A nrPDB Length = 497 Score = 231 bits (588), Expect = 8e-61, Method: Compositional matrix adjust. Identities = 141/464 (30%), Positives = 235/464 (50%), Gaps = 25/464 (5%) Query: 32 FEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEI 91 +P+T A + ++ + A+ AK AF+ W S ER + + I +R ++ Sbjct: 46 IDPSTEEACAVISLGSTRDADKAINAAKKAFQTWKTTSPHERLGFVEKILEIYEKRSSDM 105 Query: 92 ATMECINNGKSIFEARLDIDISWQC------LEYYAGLAASMAGEHIQLPGGSFGYTRRE 145 A + G A +D+ ++ Q + + + + + G + Sbjct: 106 AKTISMEMG-----APIDMALNAQTATGSSHIRNFIKAYKEFSFQEALIEGNEQAILHYD 160 Query: 146 PLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGL 205 +GV I WN+P + K PAL G MV KPS P+SA+L AEI EA +P G+ Sbjct: 161 AIGVVGLITPWNWPMNQVTLKVIPALLAGCTMVLKPSEIAPLSAMLFAEILDEAALPSGV 220 Query: 206 FNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIF 264 FN++ G GA G +L HPD+ +SFTGS G I + ++ +K V LELGGK IIF Sbjct: 221 FNLINGDGANVGSYLSAHPDLEMISFTGSTRAGKDISKNASNTLKRVCLELGGKGANIIF 280 Query: 265 SDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLED 324 +D D++ A++ + F GQ C TR+ V++ I DK + ++ ++G Sbjct: 281 ADADID-ALQRGVRHCFYNSGQSCNAPTRMLVEQAIYDKAIKTAKDIAEKTQVGPGHQTG 339 Query: 325 TRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDD 384 +GP++++ +++ ++ ++GA ++ GG +P ++ GYY+RP V + + Sbjct: 340 NHIGPVVSKEQYDKIQDLIQSGIDEGATLVTGG-TGLPMG--MERGYYVRPTVFADVKPH 396 Query: 385 MTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCF 444 M +EEIFGPV+S+L F+TE E + ANDT +GL + ++D + R+ A++++G Sbjct: 397 MRIFREEIFGPVLSLLPFNTEDEAVTLANDTEYGLTNYIQSQDRSKCRRIAAQVRSGMVE 456 Query: 445 INNYNVSPVELP----FGGYKKSGFGRENGRVTIEYYSQLKTVC 484 +N + ELP FGG K SG RE G I+ + K + Sbjct: 457 VNGH-----ELPGGSYFGGVKFSGRAREGGLWGIKEFLDTKAIS 495 >3QAN-A nrPDB Length = 538 Score = 230 bits (587), Expect = 1e-60, Method: Compositional matrix adjust. Identities = 139/470 (29%), Positives = 238/470 (50%), Gaps = 25/470 (5%) Query: 30 KAFEPA-TGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIRERE 88 +++ PA +++ + + + + A+Q+A AF+ W + ER IL++AA IIR R+ Sbjct: 54 QSWNPARKDQLVGSVSKANQDLAEKAIQSADEAFQTWRNVNPEERANILVKAAAIIRRRK 113 Query: 89 DEIATMECINNGKSIFEARLDIDISWQCLEYYAG--LAASMAGEHIQLPG--GSFGYTRR 144 E + GK EA D + LEYYA + + E + PG + YT Sbjct: 114 HEFSAWLVHEAGKPWKEADADTAEAIDFLEYYARQMIELNRGKEILSRPGEQNRYFYT-- 171 Query: 145 EPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPG 204 P+GV V I WN+ I + + GN +V KP+ TPV A E+ +AG+P G Sbjct: 172 -PMGVTVTISPWNFALAIMVGTAVAPIVTGNTVVLKPASTTPVVAAKFVEVLEDAGLPKG 230 Query: 205 LFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSA------KGIKPVTLELGG 257 + N V G GA G +L HP + ++FTGS G+++ E +A +K V +E+GG Sbjct: 231 VINYVPGSGAEVGDYLVDHPKTSLITFTGSKDVGVRLYERAAVVRPGQNHLKRVIVEMGG 290 Query: 258 KSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKI 317 K +++ D D++ A + L++ F GQ C G+R + K++ D+ E+ V + + + Sbjct: 291 KDTVVVDRDADLDLAAESILVSAFGFSGQKCSAGSRAVIHKDVYDEVLEKTVALAKNLTV 350 Query: 318 GDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCV 377 GDP D MGP+I+ E+++ ++++ K++G +++ GG + G++++P + Sbjct: 351 GDPTNRDNYMGPVIDEKAFEKIMSYIEIGKKEG-RLMTGG------EGDSSTGFFIQPTI 403 Query: 378 LTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAE 437 + + + ++EEIFGPV++ + LE AN+T +GL V TR+ + E Sbjct: 404 IADLDPEAVIMQEEIFGPVVAFSKANDFDHALEIANNTEYGLTGAVITRNRAHIEQAKRE 463 Query: 438 LQAGTCFINNYNVSPV--ELPFGGYKKSGF-GRENGRVTIEYYSQLKTVC 484 G + N + PFGG+K SG + G + + Q KTV Sbjct: 464 FHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQAKTVS 513 >3VZ3-A nrPDB Length = 457 Score = 227 bits (579), Expect = 9e-60, Method: Compositional matrix adjust. Identities = 139/453 (30%), Positives = 212/453 (46%), Gaps = 6/453 (1%) Query: 34 PATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIAT 93 P TG + F E++ + A+ AF+ + + S +R + L AA I+ + A Sbjct: 11 PTTGEICQRFKALTPAEIDAKLAKAQEAFQAYRRTSFSQRRQWLENAAAILERDTSKFAE 70 Query: 94 MECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGI 153 + GK+ A + + S YYA + Y +PLG+ + + Sbjct: 71 IMTTEMGKTHQSAIAEAEKSALVCRYYAEHGEQFLANEYTETQATESYVCYQPLGILLAV 130 Query: 154 GAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGA 213 WN+PF +APAL GN V K + P AL + I AG P G+F + GA Sbjct: 131 MPWNFPFWQVFRFAAPALMAGNVAVLKHASNVPQCALAVEAILEAAGFPEGVFQTLLIGA 190 Query: 214 ATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAV 273 + + + + P V + TGS P G + ++ + IKP LELGG P ++F D++ AV Sbjct: 191 SQVEQVIKDPRVKAATLTGSEPAGASLASLAGQEIKPTLLELGGSDPFVVFPSADLDEAV 250 Query: 274 KGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINR 333 + +A + GQ R + + I +F E++ + +KIGDP+ +T +GPL Sbjct: 251 EVGTVARTMNNGQSAIAAKRFILHEAIAAEFLEKLHLKFASLKIGDPMAPETDIGPLATE 310 Query: 334 PHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIF 393 L+ + V A GAK+L GG P + GY+ P +LT ++EE+F Sbjct: 311 GILQDISRQVDQAVAAGAKILLGG------RPLDRAGYFYPPTILTEIPPGAKILQEELF 364 Query: 394 GPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPV 453 PV + + + + AND FGL A +T D R + EL AG FIN S Sbjct: 365 APVAMVFTVKDLDQAIALANDIPFGLGASAWTNDPAEQQRFIQELDAGAVFINGMVKSDP 424 Query: 454 ELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 486 LPFGG K+SG+GRE G I + KTV ++ Sbjct: 425 RLPFGGTKRSGYGRELGLAGIRTFVNAKTVWLK 457 >3RJL-A nrPDB Length = 538 Score = 224 bits (572), Expect = 5e-59, Method: Compositional matrix adjust. Identities = 136/457 (29%), Positives = 224/457 (49%), Gaps = 18/457 (3%) Query: 39 VIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECIN 98 V+ T + + + A+Q A AF+ W ER +L A +R ++ E + + Sbjct: 64 VVGTVSKATQDHAEKAIQAAAKAFETWRYTDPEERAAVLFRAVAKVRRKKHEFSALLVKE 123 Query: 99 NGKSIFEARLDIDISWQCLEYYAGLAASMA-GEHIQLPGGSFGYTRREPLGVCVGIGAWN 157 GK EA D + +EYYA +A G+ + G P GV V I WN Sbjct: 124 AGKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSREGERNQYVYTPTGVTVVIPPWN 183 Query: 158 YPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG-GAATG 216 + F I + + + GN +V KP+ PV A E+ E+G+P G+ N V G GA G Sbjct: 184 FLFAIMAGTTVAPIVTGNTVVLKPASAAPVIAAKFVEVLEESGLPKGVVNFVPGSGAEVG 243 Query: 217 QFLCQHPDVAKVSFTGSVPTGMKIMEMSAK------GIKPVTLELGGKSPLIIFSDCDMN 270 +L HP + ++FTGS G +I E +AK +K V E+GGK +++ DCD+ Sbjct: 244 DYLVDHPKTSIITFTGSREVGTRIFERAAKVQPGQTHLKQVIAEMGGKDTVVVDEDCDIE 303 Query: 271 NAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPL 330 A + + F GQ C G+R V +++ D+ + V++ T+ K+G+P D MGP+ Sbjct: 304 LAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYDEVLKRVIEITESKKVGEPDSADVYMGPV 363 Query: 331 INRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKE 390 I++ +++ ++++ KE+G +++ GG +D K GY++ P + + ++E Sbjct: 364 IDQASFNKIMDYIEIGKEEG-RLVSGGK---GDDSK---GYFIEPTIFADLDPKARLMQE 416 Query: 391 EIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNV 450 EIFGPV++ + E LE AN+T +GL V T++ +R E G + N Sbjct: 417 EIFGPVVAFSKVSSFDEALEVANNTEYGLTGAVITKNRDHINRAKQEFHVGNLYFNRNCT 476 Query: 451 SPV--ELPFGGYKKSGF-GRENGRVTIEYYSQLKTVC 484 + PFGG+K SG + G + + Q KT+ Sbjct: 477 GAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQAKTIS 513 >6FK3-A nrPDB Length = 536 Score = 223 bits (567), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 148/464 (31%), Positives = 234/464 (50%), Gaps = 18/464 (3%) Query: 39 VIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECIN 98 V+A F + + V A A+ AF WS+ R ++L +I+ + + + Sbjct: 46 VVARFPEADKDLVRKAALKAREAFAEWSRTPAPIRGQVLFNLVKILEREKPTLTRLMVRE 105 Query: 99 NGKSIFEARLDIDISWQCLEYYAGLAASMAGEHI--QLPGGSFGYTRREPLGVCVGIGAW 156 GK+ EA D+ + ++A + G+ + ++ +T R PLGV I A Sbjct: 106 VGKTPKEAAGDVQEAIDTALFFASEGRRLYGQTVPSEMRDKEL-FTFRRPLGVVGIITAG 164 Query: 157 NYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGG--AA 214 N+P + SWK PA+ GN +V+KPS P + + A+++ EAG+PPG+ NVV GG + Sbjct: 165 NFPIAVPSWKLIPAVLTGNTVVWKPSEDAPTLSFVFAKLFEEAGLPPGVLNVVFGGGKGS 224 Query: 215 TGQFLCQHPD---VAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNN 271 TGQ++ + D K +FTGS G I E++ + + TLELGGK+PL++ D D++ Sbjct: 225 TGQWMVELMDEGLFQKFAFTGSTQVGRWIGEVAGRNLIRPTLELGGKNPLVVMRDADLDL 284 Query: 272 AVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLE-DTRMGPL 330 AV+GA + F T GQ C + + V I ++F +++ + +G+PLL + GP Sbjct: 285 AVEGAWWSAFATGGQRCTSAGNILVDAPIYEEFKRRFLERVEATLVGNPLLHPEVTYGPF 344 Query: 331 INRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPK---LKD---GYYMRPCVLTNCRDD 384 IN R +V + +GA++L G E+P L D G Y P V R Sbjct: 345 INERFFARWQEHYRVGEAEGARLLFGRGRITRENPYPRFLGDPEAGLYGWPTVW-EVRPG 403 Query: 385 MTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCF 444 EE+FGP ++++ D E + AN T +GL++ ++T A+ ++AG Sbjct: 404 TRLFTEEVFGPTINLVKVDGIEEAIAVANSTPYGLSSAIYTNHRHWAYLFKVGIRAGMTS 463 Query: 445 INNYNV-SPVELPFGGYKKSGF-GRENGRVTIEYYSQLKTVCVE 486 INN V + LPFGG K SG GRE+G +E Y+ V E Sbjct: 464 INNATVGAEAHLPFGGVKASGNGGRESGIWVLEEYTYWHAVNEE 507 >4DNG-A nrPDB Length = 485 Score = 221 bits (563), Expect = 5e-58, Method: Compositional matrix adjust. Identities = 132/466 (28%), Positives = 236/466 (50%), Gaps = 18/466 (3%) Query: 28 TEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIRER 87 TE P VI T + + K++ A A+ A K W++ + +R +L +A + E Sbjct: 23 TEDILNPYDQSVITTASLATGKQLEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHEN 82 Query: 88 EDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTR---R 144 D+I M G +I ++ ++++ + L+ + G ++P G T R Sbjct: 83 RDDIIMMIARETGGTIIKSTIELEQTIAILDEAMTYTGELGGVK-EVPSDIEGKTNKIYR 141 Query: 145 EPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSA-LLLAEIYSEAGVPP 203 PLGV I +N+P ++ APA+A GN++V KP T +S ++A+ + AG+P Sbjct: 142 LPLGVISSISPFNFPMNLSMRSIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPA 201 Query: 204 GLFNVVQGGAA-TGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLI 262 G+ NV+ G + +P +SFTGS G I E++ + K + LELGG +P Sbjct: 202 GVLNVMLTDVKEIGDGMLTNPIPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFA 261 Query: 263 IFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLL 322 + SD D++ AV A+ F+ QGQ+C R+ V +++ D+F E+ + +++ GD Sbjct: 262 VLSDADVDRAVDAAIFGKFIHQGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTD 321 Query: 323 EDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCR 382 T +GPLIN +E+ L ++ AK G ++ G + G + P V Sbjct: 322 PKTVVGPLINERQIEKALEIIEQAKTDGIELAVEGK---------RVGNVLTPYVFVGAD 372 Query: 383 DDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGT 442 ++ + E+F P+ +I+ ++ E ++ ANDT +GL++ VFT D+++ + ++ +G Sbjct: 373 NNSKIAQTELFAPIATIIKAGSDQEAIDMANDTEYGLSSAVFTSDLEKGEKFALQIDSGM 432 Query: 443 CFINNYNV--SPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 486 +N+ +V SP + FGG K SG GR +E ++ K + ++ Sbjct: 433 THVNDQSVNDSP-NIAFGGNKASGVGRFGNPWVVEEFTVTKWISIQ 477 >4ZZ7-A nrPDB Length = 501 Score = 219 bits (558), Expect = 2e-57, Method: Compositional matrix adjust. Identities = 137/466 (29%), Positives = 224/466 (48%), Gaps = 15/466 (3%) Query: 28 TEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIRER 87 ++ F PATG + + K V A+ A+ AF W ++R R++ ++ + Sbjct: 22 SQNVFNPATGEIGKQLDLASTKTVEQAISAAQHAFPTWRNTPPLKRARVMFRFKELLEQH 81 Query: 88 EDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPG-GSFGYTRREP 146 DEI + +GK +A ++ + +EY G + GEH + G G ++ +P Sbjct: 82 ADEICRLIGEEHGKIAHDAMGELQRGIENVEYACGAPELLKGEHSRNVGPGIDSWSEFQP 141 Query: 147 LGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLF 206 +GV GI +N+P + W A+ CGN V KPS P S L +A++ EAG+P G+ Sbjct: 142 MGVVAGITPFNFPVMVPLWMFPMAIVCGNCFVLKPSERDPSSTLYIAQLLQEAGLPDGVM 201 Query: 207 NVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSD 266 NVV G L V VSF GS P I ++ K G K+ I+ D Sbjct: 202 NVVNGDKEAVDALLHDDRVKAVSFVGSTPIAEYIYRTASANGKRCQALGGAKNHAIVMPD 261 Query: 267 CDMNNAVKGALMANFLTQGQVCCN-GTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDT 325 DM+NAV L A F + G+ C V V D ++ + Q++K+G Sbjct: 262 ADMDNAVNQLLGAAFGSSGERCMALSVAVAVGDAAGDALVSKMTQAMQKLKVGPSTDSGN 321 Query: 326 RMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDM 385 GP+I R H E+V+G++ A++QGA ++ G P+ P ++G+++ ++ + +M Sbjct: 322 DFGPVITRQHQEKVIGYINSAEQQGATIVVDG--RQPKVPNHENGFFVGGTLIDHVTPEM 379 Query: 386 TCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFI 445 T +EEIFGPV+ ++ T + ++ + +G +FTRD + A +Q G I Sbjct: 380 TSYQEEIFGPVLQVVRVATMQDAMDLIDAHEYGNGTCIFTRDGEAARYFSDNIQVGMVGI 439 Query: 446 NNYNVSPVELP-----FGGYKKSGFG--RENGRVTIEYYSQLKTVC 484 N P+ +P FGG+K+S FG G + +Y++ KTV Sbjct: 440 N----IPLPVPVAYHSFGGWKRSLFGDLHAYGPDAVRFYTKRKTVT 481 >3VZ0-A nrPDB Length = 459 Score = 219 bits (557), Expect = 3e-57, Method: Compositional matrix adjust. Identities = 137/459 (29%), Positives = 224/459 (48%), Gaps = 11/459 (2%) Query: 30 KAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI-WSQKSGMERCRILLEAARIIRERE 88 + P T V +F ++ A+ +K W +S +R I+ AA ++R Sbjct: 8 QTLNPTTETVERSFDLHTPAQMKDITDRAEHVWKTDWKLRSIAQRKEIVSRAADLLRRDR 67 Query: 89 DEIATMECINNGKSIFEARLDIDISWQCLEYYA-GLAASMAGEHIQLPGGSFGYTRREPL 147 A++ GK++ +A +ID++ L +YA G +A +++ G +PL Sbjct: 68 QHHASLIATEMGKALPDALEEIDVTADILSFYANGAEEFLAPTPLKVKTGQ-AKIINQPL 126 Query: 148 GVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLF- 206 G+ I WN+P+ + + P L GN ++ K +P P AL +++ +AG P G + Sbjct: 127 GIIYCIEPWNFPYYQLARVAGPNLMAGNVVIAKHAPNVPQCALAFEKLFHDAGAPVGAYA 186 Query: 207 NVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSD 266 N+ + + L + + V+ TGS G + + +K T+ELGG I+ D Sbjct: 187 NIFLDNDQSAE-LIKDERIRGVALTGSERAGQAVAAQAGAALKKDTMELGGSDAFIVLDD 245 Query: 267 CDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTR 326 D++ AVK A+ F GQVC R+ V +++ D F + + R +IG+PL DT Sbjct: 246 ADLDLAVKWAVWGRFANNGQVCTAAKRMIVHEKVYDAFLDGLKTAITRFRIGNPLDRDTT 305 Query: 327 MGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMT 386 GP+ + +E L A + GA ++ GG + G++M P +LT+ D Sbjct: 306 HGPMSSLRAMELALDQTAEAVKGGATLVAGGKRMD------RKGFFMEPTILTDVSKDNP 359 Query: 387 CVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFIN 446 +EIFGPV + +E ++ AND+ +GL VF+RDI RA +V +++ G FIN Sbjct: 360 VFYQEIFGPVAVVHKVASEQAAIDLANDSPYGLGGAVFSRDIARAEKVAEQVETGMVFIN 419 Query: 447 NYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCV 485 + ELPFGG K SGFGRE + IE + K V + Sbjct: 420 TATAAAPELPFGGIKNSGFGRELSFLGIEEFINRKLVRI 458 >3PRL-A nrPDB Length = 505 Score = 218 bits (555), Expect = 5e-57, Method: Compositional matrix adjust. Identities = 146/441 (33%), Positives = 216/441 (48%), Gaps = 20/441 (4%) Query: 34 PATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIAT 93 PA+G + + ++EVN A+Q AK A KIW + ER +L A ++ ER++ I Sbjct: 34 PASGVALGSIPALSQEEVNDAIQGAKDAQKIWKIRPIHERVDLLYAWADLLEERKEIIGE 93 Query: 94 MECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHI---QLPGGS---FGYTRREPL 147 + K A ++ + + + A A + GE + Q GGS REPL Sbjct: 94 LIMHEVAKPKKSAIGEVSRTADIIRHTADEALRLNGETLKGDQFKGGSSKKIALVEREPL 153 Query: 148 GVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFN 207 GV + I +NYP +A+ K APAL GN +VFKP+ +S + + E ++AG P G+ Sbjct: 154 GVVLAISPFNYPVNLAAAKIAPALVTGNTVVFKPATQGSLSGIKMVEALADAGAPEGIIQ 213 Query: 208 VVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSD 266 VV G G+ G L +HP + ++FTG TG +I E AK I PV LELGGK P I+ D Sbjct: 214 VVTGRGSVIGDHLVEHPGIDMITFTGGTTTGERISE-KAKMI-PVVLELGGKDPAIVLDD 271 Query: 267 CDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTR 326 D+ + F GQ C RVFVQ + D+ + + +++ +G P +D Sbjct: 272 ADLKLTASQIVSGAFSYSGQRCTAIKRVFVQDSVADQLVANIKELVEQLTVGSP-EDDAD 330 Query: 327 MGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMT 386 + P+I+ + G + A E GA +L G + G + P +L + M Sbjct: 331 ITPVIDEKSAAFIQGLIDDALENGATLLSGNK---------RQGNLLSPTLLDDVTPAMR 381 Query: 387 CVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFIN 446 EE FGPV+ I+ E + +N + +GL A +FT+D RA + L+ GT IN Sbjct: 382 VAWEEPFGPVLPIIRVKDANEAISLSNQSDYGLQASIFTKDTDRAINIGKHLEVGTVHIN 441 Query: 447 -NYNVSPVELPFGGYKKSGFG 466 P PF G KKSG G Sbjct: 442 AKTERGPDHFPFLGVKKSGLG 462 >5KF0-A nrPDB Length = 485 Score = 216 bits (550), Expect = 2e-56, Method: Compositional matrix adjust. Identities = 136/410 (33%), Positives = 202/410 (49%), Gaps = 19/410 (4%) Query: 84 IREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQL-----PGGS 138 RER DE+A CI GK I ++R ++ + A + GE + L G Sbjct: 84 FRERFDELAEALCIEAGKPINDSRGEVTRLIDTFRVASEEAVRIDGEVLNLEISARAQGY 143 Query: 139 FGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSE 198 GYTRR P+G C I +N+P +A+ K APALA G V KP+ TPV AL++AE+ +E Sbjct: 144 TGYTRRVPIGPCSFISPFNFPLNLAAHKVAPALAAGCPFVLKPASRTPVGALIIAEVLAE 203 Query: 199 AGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGK 258 +P G F+V+ +SFTGS G + E + K K V LELGG Sbjct: 204 TNLPKGAFSVLPAHRDGADLFTTDERFRLLSFTGSPAVGWALKEKAGK--KKVVLELGGN 261 Query: 259 SPLIIFSDC--DMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIK 316 + I+ +D ++ V + GQ C R+ V + D +++V +T+ +K Sbjct: 262 AAAIVDADQFEQLDYVVDRLAFGAYYQSGQSCIGVQRILVHASLYDTLRDKLVAKTRSLK 321 Query: 317 IGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPC 376 +GDP T +GP+I+ R+ G++ A GAK++ GG + DG Sbjct: 322 MGDPKDPSTFVGPMISESESRRLSGWMDAAVAAGAKIIAGGKV---------DGAMFEAT 372 Query: 377 VLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVA 436 +L + + ++E FGPV + FD + L R ND+ FGL AGVFT + A R Sbjct: 373 LLEDVGREQDLYRKEAFGPVAILEKFDRFDDALARVNDSDFGLQAGVFTDSLTHAQRAWD 432 Query: 437 ELQAGTCFINNYNVSPVE-LPFGGYKKSGFGRENGRVTIEYYSQLKTVCV 485 EL+ G IN+ V+ +P+GG K SG GRE R IE ++ + + V Sbjct: 433 ELEVGGVVINDVPSFRVDNMPYGGVKDSGLGREGIRYAIEDMTEPRLMVV 482 >3ROS-A nrPDB Length = 484 Score = 216 bits (549), Expect = 2e-56, Method: Compositional matrix adjust. Identities = 135/443 (30%), Positives = 210/443 (47%), Gaps = 14/443 (3%) Query: 30 KAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIRERED 89 ++ P T A++ K+++ A+ A A +K W + R IL + A ++E ED Sbjct: 7 QSVNPYTNEAFASYDNPTSKQIDEAINLAHALYKKWRHEEPASRAEILHDIANALKEHED 66 Query: 90 EIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGV 149 E+A M + GK + E++ ++++ YYA M Y ++ GV Sbjct: 67 ELAKMMTLEMGKLLSESKEEVELCVSICNYYADHGPEMLKPTKLNSDLGNAYYLKQSTGV 126 Query: 150 CVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPG-LFNV 208 + WN+P AP GN ++ K + P SA L A+I AG P G L N+ Sbjct: 127 IMACEPWNFPLYQVIRVFAPNFIVGNPILLKHAHNVPGSAALTAKIIKRAGAPEGSLINL 186 Query: 209 VQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCD 268 + P + V+ TGS G + E + K +K T+ELGG I+ D D Sbjct: 187 YPSYDQLADIIAD-PRIQGVALTGSERGGSAVAEAAGKNLKKSTMELGGNDAFIVLDDAD 245 Query: 269 ---MNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDT 325 + N + A N GQVC + R+ V+K D+ E+ +K GDPL DT Sbjct: 246 PQVLRNVLNDARTYN---DGQVCTSSKRIIVEKSRYDEVLHELKNVFSNLKAGDPLEADT 302 Query: 326 RMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDM 385 + P+ + E++ VK A + GAKV Y D K G + RP +LT+ D Sbjct: 303 TLPPMNSEKAKEKLEAQVKEAIDAGAKVFYQ---YPEIDSK---GAFFRPTILTDIAKDN 356 Query: 386 TCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFI 445 +E+FGP+ + + + ++ AND+++GL + V DI RA +V A+++ G I Sbjct: 357 PVFDKEVFGPIAEVFVVEDDNAAIQLANDSSYGLGSSVIGSDIDRAKKVSAQIETGMTVI 416 Query: 446 NNYNVSPVELPFGGYKKSGFGRE 468 N ++ ELPFGG KKSG+GRE Sbjct: 417 NGRWITSGELPFGGIKKSGYGRE 439 >5JRY-A nrPDB Length = 485 Score = 214 bits (544), Expect = 9e-56, Method: Compositional matrix adjust. Identities = 134/410 (32%), Positives = 200/410 (48%), Gaps = 19/410 (4%) Query: 84 IREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQL-----PGGS 138 RER DE+A CI GK I +A+ ++ + A + GE + L G Sbjct: 84 FRERFDELAEALCIEAGKPINDAKGEVTRLIDTFRVASEEAVRIDGEVLNLEISARAQGY 143 Query: 139 FGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSE 198 GYTRR P+G C I +N+P +A+ K APALA G V KP+ TPV AL++ E+ +E Sbjct: 144 TGYTRRVPIGPCSFISPFNFPLNLAAHKVAPALAAGCPFVLKPASRTPVGALIIGEVLAE 203 Query: 199 AGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGK 258 +P G F+V+ +SFTGS G + E + K K V LELGG Sbjct: 204 TDLPKGAFSVLPAHRDGADLFTTDDRFRLLSFTGSPAVGWALKEKAGK--KKVVLELGGN 261 Query: 259 SPLIIFSDC--DMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIK 316 + I+ +D ++ V F GQ C R+ +I D ++++ +T+ +K Sbjct: 262 AAAIVDADQLDRLDYVVDRLAFGAFYQSGQSCIGVQRILAHADIYDALRDKLIAKTRSLK 321 Query: 317 IGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPC 376 +GDP T +GP+I+ R+ G++ A GAK++ GG + DG Sbjct: 322 MGDPKDPSTFVGPMISESESRRLSGWMDAAVAAGAKIVAGGKV---------DGAMFEAT 372 Query: 377 VLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVA 436 +L N D ++E FGP+ + FD + L R ND+ FGL AGVFT + + Sbjct: 373 LLENVGRDQDLYRKEAFGPIAILEKFDRFDDALARVNDSDFGLQAGVFTDSLAHTQQAWD 432 Query: 437 ELQAGTCFINNYNVSPVE-LPFGGYKKSGFGRENGRVTIEYYSQLKTVCV 485 EL+ G IN+ V+ +P+GG K SG GRE R IE ++ + + V Sbjct: 433 ELEVGGVVINDVPSFRVDNMPYGGVKDSGLGREGIRYAIEDMTEPRLLVV 482 >5TJR-A nrPDB Length = 531 Score = 213 bits (543), Expect = 1e-55, Method: Compositional matrix adjust. Identities = 136/466 (29%), Positives = 228/466 (48%), Gaps = 7/466 (1%) Query: 23 ADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAAR 82 AD T F P+TG + + + + A+ AKAAF W +R ++L + Sbjct: 47 ADTGRTADVFNPSTGEAVRKVPLADRETMQQAIDAAKAAFPAWRNTPPAKRAQVLFRFKQ 106 Query: 83 IIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSF-GY 141 ++ E+ I + +GK+I +A ++ + +EY + GE+ + G + + Sbjct: 107 LLEANEERIVKLISEEHGKTIEDAAGELKRGIENVEYATAAPEILKGEYSRNVGPNIDAW 166 Query: 142 TRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGV 201 + +P+GV GI +N+P + W A+ACGN + KPS P S LL+AE++ EAG+ Sbjct: 167 SDFQPIGVVAGITPFNFPAMVPLWMYPLAIACGNTFILKPSERDPSSTLLIAELFHEAGL 226 Query: 202 PPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPL 261 P G+ NVV G L + P+V +SF GS P I K K V G K+ Sbjct: 227 PKGVLNVVHGDKGAVDALIEAPEVKALSFVGSTPIAEYIYSEGTKRGKRVQALGGAKNHA 286 Query: 262 IIFSDCDMNNAVKGALMANFLTQGQVCCN-GTRVFVQKEILDKFTEEVVKQTQRIKIGDP 320 ++ D D++NAV + A + + G+ C V V +I D +++V Q + +KIG Sbjct: 287 VLMPDADLDNAVSALMGAAYGSCGERCMAISVAVCVGDQIADALVQKLVPQIKGLKIGAG 346 Query: 321 LLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTN 380 MGPL+ ++V G++ QGA+++ G Y + ++G+++ + Sbjct: 347 TSCGLDMGPLVTGAARDKVTGYIDTGVAQGAELVVDGRGY--KVAGHENGFFLGGTLFDR 404 Query: 381 CRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQA 440 +MT KEEIFGPV+ I+ ++ E ++ ND +G +FTRD + A E++ Sbjct: 405 VTPEMTIYKEEIFGPVLCIVRVNSLEEAMQLINDHEYGNGTCIFTRDGEAARLFCDEIEV 464 Query: 441 GTCFINNYNVSPVEL-PFGGYKKSGFG--RENGRVTIEYYSQLKTV 483 G +N PV FGG+K+S FG G + +Y++ K + Sbjct: 465 GMVGVNVPLPVPVAYHSFGGWKRSLFGDLHAYGPDGVRFYTKRKAI 510 >4E4G-A nrPDB Length = 521 Score = 213 bits (541), Expect = 2e-55, Method: Compositional matrix adjust. Identities = 145/491 (29%), Positives = 243/491 (49%), Gaps = 25/491 (5%) Query: 10 QPLNYRGGARVEPADASGTE----KAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIW 65 Q + Y G ++ +GT F PATG V T + + ++ AV++AKAA W Sbjct: 21 QSMMYELGHFIDGKRVAGTSGRVSNIFNPATGEVQGTVALASDADLAAAVESAKAAQPKW 80 Query: 66 SQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAA 125 + + R R+ ++ +++ + +E+A M +GK+I +A+ DI + E+ G+ Sbjct: 81 AATNPQRRARVFMKFVQLLNDNMNELAEMLSREHGKTIDDAKGDIVRGLEVCEFVIGIPH 140 Query: 126 SMAGEHIQLPG-GSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPF 184 E + G G Y+ R+P+G+ GI +N+P I W APA+ACGNA + KPS Sbjct: 141 LQKSEFTEGAGPGIDMYSIRQPVGIGAGITPFNFPGMIPMWMFAPAIACGNAFILKPSER 200 Query: 185 TPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMS 244 P + LAE+ EAG+P G+ NVV G + HPD+A VSF GS P + + Sbjct: 201 DPSVPIRLAELMIEAGLPAGILNVVNGDKGAVDAILTHPDIAAVSFVGSTPIARYVYGTA 260 Query: 245 AKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCN-GTRVFVQKEILDK 303 A K G K+ +II D D++ A + A + + G+ C V V +E ++ Sbjct: 261 AMNGKRAQCFGGAKNHMIIMPDADLDQAANALIGAGYGSAGERCMAISVAVPVGEETANR 320 Query: 304 FTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPE 363 +++V + ++IG E MGP++ + +R+ + EQGAK++ G Sbjct: 321 LIDKLVPMVESLRIGPYTDEKADMGPVVTKEAEQRIRSLIDSGIEQGAKLVVDG-----R 375 Query: 364 DPKLK---DGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA 420 D KL+ +G+++ C+ + DM K EIFGPV+S++ E L +G Sbjct: 376 DFKLQGYENGHFIGGCLFDDVTPDMDIYKTEIFGPVLSVVRARNYEEALSLPMKHEYGNG 435 Query: 421 AGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELP-----FGGYKKSGFG--RENGRVT 473 ++TRD A + + G +N P+ +P FGG+K S FG ++G + Sbjct: 436 VAIYTRDGDAARDFASRINIGMVGVN----VPIPVPLAYHSFGGWKSSSFGDLNQHGTDS 491 Query: 474 IEYYSQLKTVC 484 I+++++ KT+ Sbjct: 492 IKFWTRTKTIT 502 >2J5N-A nrPDB Length = 516 Score = 209 bits (532), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 133/436 (30%), Positives = 216/436 (49%), Gaps = 22/436 (5%) Query: 62 FKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYA 121 FK W +R R+LL+AA ++R R+ E+ GK+ EA D+ + +EYYA Sbjct: 87 FKTWKDWPQEDRSRLLLKAAALMRRRKRELEATLVYEVGKNWVEASADVAEAIDFIEYYA 146 Query: 122 GLAASM---AGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMV 178 A A E + PG + PLG V I WN+P I + +A GN ++ Sbjct: 147 RAALRYRYPAVEVVPYPGED-NESFYVPLGAGVVIAPWNFPVAIFTGMIVGPVAVGNTVI 205 Query: 179 FKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTG 237 KP+ V + EI+ EAG PPG+ N + G G G +L +HP + ++FTGS+ G Sbjct: 206 AKPAEDAVVVGAKVFEIFHEAGFPPGVVNFLPGVGEEVGAYLVEHPRIRFINFTGSLEVG 265 Query: 238 MKIMEMSAK------GIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNG 291 +KI E + + K +E GGK +I+ D + A +G +++ + QGQ C Sbjct: 266 LKIYEAAGRLAPGQTWFKRAYVETGGKDAIIVDETADFDLAAEGVVVSAYGFQGQKCSAA 325 Query: 292 TRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGA 351 +R+ + + + E V+K+ +R+ +G P E+ +GP+++ +VL ++++ K +G Sbjct: 326 SRLILTQGAYEPVLERVLKRAERLSVG-PAEENPDLGPVVSAEQERKVLSYIEIGKNEGQ 384 Query: 352 KVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLER 411 VL G + +GY++ P V T +EEIFGPV+S++ AE LE Sbjct: 385 LVLGGKRLE-------GEGYFIAPTVFTEVPPKARIAQEEIFGPVLSVIRVKDFAEALEV 437 Query: 412 ANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPV--ELPFGGYKKSGFGREN 469 ANDT +GL GV++R + E G + N + PFGG+K SG + Sbjct: 438 ANDTPYGLTGGVYSRKREHLEWARREFHVGNLYFNRKITGALVGVQPFGGFKLSGTNAKT 497 Query: 470 GRVT-IEYYSQLKTVC 484 G + + + ++K V Sbjct: 498 GALDYLRLFLEMKAVA 513 >2JG7-A nrPDB Length = 510 Score = 207 bits (527), Expect = 9e-54, Method: Compositional matrix adjust. Identities = 131/465 (28%), Positives = 231/465 (49%), Gaps = 18/465 (3%) Query: 31 AFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDE 90 ++ PA IA T + E VQ + A+K+W+ +R I+ + +R++ Sbjct: 39 SYCPANNEPIARVTQATLAEYEETVQKTREAWKMWADIPAPKRGEIVRQIGDALRKKIKV 98 Query: 91 IATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHI--QLPGGSFGYTRREPLG 148 + ++ + GK E ++ +Y GL+ + G + + PG + + P+G Sbjct: 99 LGSLVSLEMGKIYVEGVGEVQEYVDVCDYAVGLSRMIGGPVLPSERPGHAL-IEQWNPVG 157 Query: 149 VCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSAL----LLAEIYSEAGVPPG 204 + I A+N+P + W +A AL CGN ++K +P TP++++ ++AE+ + +P Sbjct: 158 LVGIITAFNFPVAVYGWNNAIALTCGNVCLWKGAPTTPLTSVAVTKIVAEVLEQNNLPGA 217 Query: 205 LFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIF 264 + ++ GGA G + + V +SFTGS G + M + LELGG + +I+F Sbjct: 218 ICSMTCGGADIGTAMAKDERVDLLSFTGSTHVGKMVAMMVQERFGRKLLELGGNNAIIVF 277 Query: 265 SDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLED 324 D D+N V A+ A+ T GQ C R+ + + + D E + K ++++IGDP Sbjct: 278 EDADLNLVVPSAVFASVGTAGQRCTTTRRLMLHESVHDAVVERIAKAYKQVRIGDPWDPS 337 Query: 325 TRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDD 384 T GPL + +++ L ++ AK+QG ++CGG + + G Y+ P ++T D Sbjct: 338 TLYGPLHTKQAVDQYLAAIEQAKQQGGTLVCGGKVMD------RPGNYVEPTIITGLAHD 391 Query: 385 MTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCF 444 V E F P++ +L F TE E N+ GL++ +FT+D+ R R + + C Sbjct: 392 APIVHTETFVPILYVLKFKTEEEAFAWNNEVQQGLSSSIFTKDLGRVFRWLGP-KGSDCG 450 Query: 445 INNYNV--SPVEL--PFGGYKKSGFGRENGRVTIEYYSQLKTVCV 485 I N N+ S E+ FGG K +G GRE+G + + Y + T + Sbjct: 451 IVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDSWKQYMRRSTCTI 495 >4OGD-A nrPDB Length = 465 Score = 204 bits (519), Expect = 8e-53, Method: Compositional matrix adjust. Identities = 135/438 (30%), Positives = 209/438 (47%), Gaps = 11/438 (2%) Query: 34 PATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGME-RCRILLEAARIIREREDEIA 92 P T V+ TF ++ + ++ A +K W ++ +E R L + A I+R D+ A Sbjct: 8 PYTNEVLHTFDNMTDQGLADVLERAHLLYKKWRKEDHLEERKAQLHQVANILRRDRDKYA 67 Query: 93 TMECINNGKSIFEARLDIDISWQCLEYYAGLAAS-MAGEHIQLPGGSFGYTRREPLGVCV 151 + + GK EA+ ++D+ +YYA A + ++ G Y ++ GV + Sbjct: 68 EIMTKDMGKLFTEAQGEVDLCADIADYYADKADEFLMSTPLETDSGQ-AYYLKQSTGVIL 126 Query: 152 GIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPG-LFNVVQ 210 + WN+P+ AP GN MV K + P SA E+ EAG G + N+ Sbjct: 127 AVEPWNFPYYQIMRVFAPNFIVGNPMVLKHASICPRSAQSFEELVLEAGAEAGSITNLFI 186 Query: 211 GGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMN 270 Q + V V TGS G I E + K +K TLELGG II D D + Sbjct: 187 SYDQVSQVIADKR-VVGVCLTGSERGGASIAEEAGKNLKKTTLELGGDDAFIILDDADWD 245 Query: 271 NAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPL 330 K + GQVC + R V + D+F E + K + K GDP+ +T + PL Sbjct: 246 QLEKVLYFSRLYNAGQVCTSSKRFIVLDKDYDRFKELLTKVFKTAKWGDPMDPETTLAPL 305 Query: 331 INRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKE 390 + VL +K+A + GA+++ GG+ + P G+++ P ++ D + Sbjct: 306 SSAQAKADVLDQIKLALDHGAELVYGGE--AIDHP----GHFVMPTIIAGLTKDNPIYYQ 359 Query: 391 EIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNV 450 EIFGPV I +E E +E AND+ +GL +F+ + + A V A+++ G FIN+ Sbjct: 360 EIFGPVGEIYKVSSEEEAIEVANDSNYGLGGTIFSSNQEHAKAVAAKIETGMSFINSGWT 419 Query: 451 SPVELPFGGYKKSGFGRE 468 S ELPFGG K SG+GRE Sbjct: 420 SLPELPFGGIKHSGYGRE 437 >5J6B-A nrPDB Length = 485 Score = 201 bits (511), Expect = 6e-52, Method: Compositional matrix adjust. Identities = 134/441 (30%), Positives = 213/441 (48%), Gaps = 25/441 (5%) Query: 53 LAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDI 112 + Q A + +++ +E C AR RER DE+A CI GK I +++ ++ Sbjct: 59 VGAQKPLRALPAFRRQAILEHC-----VARF-RERFDELAQALCIEAGKPINDSKGEVTR 112 Query: 113 SWQCLEYYAGLAASMAGEHIQL-----PGGSFGYTRREPLGVCVGIGAWNYPFQIASWKS 167 A + + G + L G GY +R P+G C I +N+P +A+ K Sbjct: 113 LIDTFRVAAEESVRIEGGLVNLEISPRAQGYSGYYKRVPIGPCSFISPFNFPLNLAAHKV 172 Query: 168 APALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAK 227 APALA G V KP+ TP+ AL++ E+ +E +P G F+++ Sbjct: 173 APALAAGCPFVLKPASRTPIGALIIGEVLAETDLPKGAFSILPAHRDGADLFTTDERFKL 232 Query: 228 VSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCD--MNNAVKGALMANFLTQG 285 +SFTGS G ++ + + K K V LELGG + I+ +D ++ V+ + G Sbjct: 233 LSFTGSPTVGWELKKKAGK--KKVVLELGGNAAAIVDADQREVLDYVVERLAFGAYYQSG 290 Query: 286 QVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKV 345 Q C R+ ++ D E+++ +T+ +K+GDP T +GP+I+ R+ G+++ Sbjct: 291 QSCIGVQRIIAHADVYDALREKLIAKTRSLKMGDPKDPATFVGPMISESEARRLAGWMEA 350 Query: 346 AKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTE 405 A GAK++ GG + DG +L D ++E FGPV + F Sbjct: 351 AVAAGAKIVAGGKV---------DGAMFEATLLEGVGRDQDLYRKEAFGPVALLERFSDF 401 Query: 406 AEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVE-LPFGGYKKSG 464 + L R ND+ FGL AGVFT + A R EL+ G IN+ V+ +P+GG K SG Sbjct: 402 DDALARVNDSDFGLQAGVFTDSLSHAQRAWDELEVGGVVINDVPSFRVDNMPYGGVKDSG 461 Query: 465 FGRENGRVTIEYYSQLKTVCV 485 GRE R IE ++L+ + V Sbjct: 462 LGREGIRYAIEDMTELRLMVV 482 >5N5S-A nrPDB Length = 515 Score = 194 bits (494), Expect = 6e-50, Method: Compositional matrix adjust. Identities = 125/428 (29%), Positives = 217/428 (50%), Gaps = 23/428 (5%) Query: 72 ERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEH 131 ER +L + ++ R +EIA + +GK I +AR ++ + + A + + GEH Sbjct: 99 ERKAVLEKVVAELKNRFEEIAQTLTMESGKPIKDARGEVTRTIDTFQVAAEESVRIYGEH 158 Query: 132 IQLP-----GGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTP 186 I L G G ++ P+G + WN+P + + K APA+A G V KP+ TP Sbjct: 159 IPLDISARNKGLQGIVKKFPIGPVSMVSPWNFPLNLVAHKVAPAIAVGCPFVLKPASRTP 218 Query: 187 VSALLLAEIYSE-AGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSA 245 +SAL+L EI + +P G F+++ ++FTGS P G +M A Sbjct: 219 LSALILGEILHKIEELPLGAFSILPVSREDADMFTVDERFKLLTFTGSGPIGW---DMKA 275 Query: 246 K-GIKPVTLELGGKSPLIIFSDC-DMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDK 303 + G K V +ELGG +P I+ D++ ++ + F GQ C + R++V + + D+ Sbjct: 276 RAGKKKVVMELGGNAPCIVDDYVPDLDYTIQRLINGGFYQGGQSCIHMQRLYVHERLYDE 335 Query: 304 FTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPE 363 E V +++K+G+P EDT +GP+I+ + + +VK A +G K+L GG+ Sbjct: 336 VKEGFVAAVKKLKMGNPFEEDTYLGPMISESAAKGIEDWVKEAVAKGGKLLTGGN----- 390 Query: 364 DPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGV 423 + G ++ P V+ + + KEEIFGPV+ + + E ++ N+T +GL +G+ Sbjct: 391 ----RKGAFIEPTVIEDVPIEANARKEEIFGPVVLLYKYSDFKEAVKECNNTHYGLQSGI 446 Query: 424 FTRDIQRAHRVVAELQAGTCFINNYNVSPVE-LPFGGYKKSGFGRENGRVTIEYYSQLKT 482 FT+D+ +A ++ G +N+ V+ P+GG K SG RE + ++ L+T Sbjct: 447 FTKDLNKAFYAFEHMEVGGVILNDSPALRVDSQPYGGLKDSGIQREGVKYAMD--DMLET 504 Query: 483 VCVEMGDV 490 + M +V Sbjct: 505 KVLVMRNV 512 >4X0T-A nrPDB Length = 513 Score = 188 bits (477), Expect = 5e-48, Method: Compositional matrix adjust. Identities = 128/463 (27%), Positives = 222/463 (47%), Gaps = 20/463 (4%) Query: 34 PATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIAT 93 PA IA + + V+ A+ A+KIW+ +R I+ + +RE+ + + Sbjct: 45 PANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGS 104 Query: 94 MECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRRE---PLGVC 150 + + GK + E ++ +Y GL+ + G LP G+ E P+G+ Sbjct: 105 LVSLEMGKILVEGVGEVQEYVDICDYAVGLSRMIGGP--ILPSERSGHALIEQWNPVGLV 162 Query: 151 VGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSAL----LLAEIYSEAGVPPGLF 206 I A+N+P + W +A A+ CGN ++K +P T + ++ ++A++ + +P + Sbjct: 163 GIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAIC 222 Query: 207 NVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSD 266 ++ GGA G + + V +SFTGS G ++ M + LELGG + +I F D Sbjct: 223 SLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFED 282 Query: 267 CDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTR 326 D++ V AL A T GQ C R+F+ + I D+ + K +I++G+P + Sbjct: 283 ADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVL 342 Query: 327 MGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMT 386 GPL + + LG V+ AK++G V+ GG + + G Y+ P ++T D + Sbjct: 343 YGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMD------RPGNYVEPTIVTGLGHDAS 396 Query: 387 CVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFIN 446 E F P++ + F E EV N+ GL++ +FT+D+ R R + + C I Sbjct: 397 IAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGP-KGSDCGIV 455 Query: 447 NYNV--SPVEL--PFGGYKKSGFGRENGRVTIEYYSQLKTVCV 485 N N+ S E+ FGG K +G GRE+G + Y + T + Sbjct: 456 NVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTI 498 >5U0M-A nrPDB Length = 497 Score = 186 bits (473), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 143/469 (30%), Positives = 232/469 (49%), Gaps = 48/469 (10%) Query: 30 KAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIRERED 89 ++ +P TG + + ++V+ AV+ A+ AF W +KS ER ++ ++ ++ Sbjct: 29 ESVQPVTGETVWDGNAASLEDVDAAVREARKAFLAWRRKSLAERQAVIEAFGELLEANKE 88 Query: 90 EIATMECINNGKSIFEARLD-------IDISWQCLEYYAGLAAS-MAGEHIQLPGGSFGY 141 E+A + GK ++E+R + I IS + G S +AG H L Sbjct: 89 ELAHQIGLETGKPLWESRTEVAAMMGKIPISVKAYNERTGHTESDVAGGHAVL------- 141 Query: 142 TRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGV 201 R P GV G +N+P + + PAL GN +VFKPS TP A L ++ +AG+ Sbjct: 142 -RHRPHGVVAVFGPYNFPGHLPNGHIVPALLAGNTVVFKPSELTPGVAELTVRLWEKAGL 200 Query: 202 PPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIME-MSAKGIKPVTLELGGKSP 260 P G+ N+VQGG+ TG+ L +H + + FTGS G + E + K + LE+GG +P Sbjct: 201 PDGVINLVQGGSDTGKCLARHSLIDGLFFTGSSTVGHLLHEQFGGQPEKILALEMGGNNP 260 Query: 261 LIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQK-EILDKFTEEVVKQTQRIKI-- 317 LI+ + D++ AV AL + FL+ GQ C R+ V K + D+F +V+ RI + Sbjct: 261 LIVQNVSDLDGAVHHALQSAFLSAGQRCTCARRLLVPKGKKGDEFLARLVEVAARITVAE 320 Query: 318 --GDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLK-DGYYMR 374 DP MG +I+ ++L E+GA L E +LK D + Sbjct: 321 FDADP---QPFMGSVISAEAANQLLKAQAAMLEKGATSLL-------EMKQLKPDTGLLS 370 Query: 375 PCVLTNCRDDMTCVK---EEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRA 431 P ++ D T ++ +E FGP++++ + E LE AN+T +GL+AG+ + D + Sbjct: 371 PGIV-----DATGIELEDQEFFGPLLTVYRYKGFDEALELANNTRYGLSAGILSDDRKLY 425 Query: 432 HRVVAELQAGTCFINNYNV----SPVELPFGGYKKSGFGRENGRVTIEY 476 +R+V E++AG I N+N + PFGG SG R + +Y Sbjct: 426 NRLVEEVRAG---IVNWNRPLTGASSAAPFGGVGASGNHRPSAYYAADY 471 >4I3V-A nrPDB Length = 488 Score = 186 bits (471), Expect = 3e-47, Method: Compositional matrix adjust. Identities = 123/349 (35%), Positives = 186/349 (53%), Gaps = 18/349 (5%) Query: 141 YTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAG 200 +T REPL I +N+P + + K APA+A N +V KP+ TP++ALLLA+I EAG Sbjct: 145 FTMREPLTAISAITPFNHPLNMVAHKVAPAIATNNCVVVKPTELTPMTALLLADILYEAG 204 Query: 201 VPPGLFNVVQGGAA-TGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKS 259 +PP + +VV G A G + +P V V+FTGSVP G K++ +A + V LELGG Sbjct: 205 LPPEMLSVVTGWPADIGMEMITNPHVDLVTFTGSVPVG-KLIAANAHYKRQV-LELGGND 262 Query: 260 PLII---FSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIK 316 PLII SD D+ A A+ GQ C R+ Q+ + D+F V+++ +R++ Sbjct: 263 PLIILNDLSDDDLARAADLAVAGATKNSGQRCTAVKRILCQESVADRFVPLVLERAKRLR 322 Query: 317 IGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPC 376 GDP+ T +G +I+ V A E+GA +L Y P + G + P Sbjct: 323 FGDPMDRSTDLGTVIHEKAAALFEERVMRAAEEGADIL-----YHPG----RSGALLPPI 373 Query: 377 VLTNCRDDMTCVKEEIFGPVMSILSF-DTEAEVLERANDTTFGLAAGVFTRDIQRAHRVV 435 V+ V EE FGP++ I+ D + + +N T FGL++GV T D +R + + Sbjct: 374 VVDRVPHQSDLVLEETFGPIIPIVRVPDDDDATITLSNSTAFGLSSGVCTNDYRRMQKYI 433 Query: 436 AELQAGTCFINNYNVSPVEL-PFGGYKKSGFGRENGRV-TIEYYSQLKT 482 A L+ GT I +E+ PFGG K SG G + G + ++ ++ +KT Sbjct: 434 AGLKVGTVNIWEVPGYRIEMSPFGGIKDSGNGYKEGVIEAMKSFTNVKT 482 >1UXV-A nrPDB Length = 501 Score = 183 bits (464), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 131/433 (30%), Positives = 200/433 (46%), Gaps = 25/433 (5%) Query: 65 WSQKS--GMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAG 122 WS + G ER +L +AA II D A + +N GK A ++ + L Sbjct: 69 WSARDMPGTERLAVLRKAADIIERNLDVFAEVLVMNAGKPKSAAVGEVKAAVDRLRLAEL 128 Query: 123 LAASMAGEHIQLPGG-------SFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGN 175 + G++I PG + G RREPLGV I +NYP A K + GN Sbjct: 129 DLKKIGGDYI--PGDWTYDTLETEGLVRREPLGVVAAITPFNYPLFDAVNKITYSFIYGN 186 Query: 176 AMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVP 235 A+V KPS P+ A + + +AG PP ++ + + VA VSFTGS Sbjct: 187 AVVVKPSISDPLPAAMAVKALLDAGFPPDAIALLNLPGKEAEKIVADDRVAAVSFTGSTE 246 Query: 236 TGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVF 295 G +++++ G+K +ELGG P I+ D D++ A + GQ C V Sbjct: 247 VGERVVKVG--GVKQYVMELGGGDPAIVLEDADLDLAADKIARGIYSYAGQRCDAIKLVL 304 Query: 296 VQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLC 355 ++ + K EEV K+ +++GDP +GPLI+ ++ ++ ++ A E+G +VL Sbjct: 305 AERPVYGKLVEEVAKRLSSLRVGDPRDPTVDVGPLISPSAVDEMMAAIEDAVEKGGRVLA 364 Query: 356 GGDIYVPEDPKLKDGYYMRPCVLTNCRD---DMTCVKEEIFGPVMSILSFDTEAEVLERA 412 GG P Y++P ++ D DM K E+F PV + + +E A Sbjct: 365 GGRRLGPT--------YVQPTLVEAPADRVKDMVLYKREVFAPVALAVEVKDLDQAIELA 416 Query: 413 NDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPV-ELPFGGYKKSGFGRENGR 471 N +GL A VF RD+ + R V L+ G +IN+ + PFGG KKSG RE Sbjct: 417 NGRPYGLDAAVFGRDVVKIRRAVRLLEVGAIYINDMPRHGIGYYPFGGRKKSGVFREGIG 476 Query: 472 VTIEYYSQLKTVC 484 +E + KT+ Sbjct: 477 YAVEAVTAYKTIV 489 >5UR2-A nrPDB Length = 984 Score = 183 bits (464), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 127/422 (30%), Positives = 208/422 (49%), Gaps = 22/422 (5%) Query: 61 AFKIWSQKSGMERCRILLEAARII-REREDEIATMECINNGKSIFEARLDIDISWQCLEY 119 A+K W +R ++ + A I+ R+R IAT + + GK EA DI + Y Sbjct: 545 AYKTWKNVPCEQRAALVDKLADIMTRDRFKLIAT-QVLEVGKPWAEADGDIGEAIDFCRY 603 Query: 120 YAGLAASMAGEHIQLPG--GSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAM 177 YA + + +++ G G + + GV I WN+P I + A GN + Sbjct: 604 YARHMRELQ-KPLRVGGLPGELSHYIYKSRGVTAVIAPWNFPLAILAGMVTAAAVAGNTV 662 Query: 178 VFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPT 236 V KP+ + V A L ++ EAG P G+ N + G G G+++ H ++FTGS Sbjct: 663 VMKPAEQSTVVAWGLMKMIQEAGFPQGVINFLPGYGEEVGEYIVNHKYTTTIAFTGSKAV 722 Query: 237 GMKIMEMSA------KGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCN 290 G+ IM +A + +K +E+GGK+ +II +D D++ AV G + + F GQ C Sbjct: 723 GLHIMNRAAVVQPGQQHVKRCIIEMGGKNAVIIDNDADLDEAVDGVIYSAFGFSGQKCSA 782 Query: 291 GTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQG 350 +RV V E+ D+F + +V+ + I+I MGP++++ +R+LG + A E+ Sbjct: 783 ASRVIVLDEVYDRFVDRLVETAKSIEIHPAENPKAYMGPVVDKEAYDRILGTIAEA-EKN 841 Query: 351 AKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLE 410 K+L G VP G++ P + + D + EIFGPV++++ + L+ Sbjct: 842 HKLLFKGS--VP-----GGGFFAPPTIFGDVPGDAKLAQAEIFGPVVAVIRAKNLDQALD 894 Query: 411 RANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPV--ELPFGGYKKSGFGRE 468 AN T + L GVF+R +RV EL+ G ++N + PFGG+K SG G + Sbjct: 895 IANSTEYALTGGVFSRSPANINRVKEELEVGNLYVNRGITGAMVDRHPFGGFKMSGIGSK 954 Query: 469 NG 470 G Sbjct: 955 TG 956 >6DBB-A nrPDB Length = 511 Score = 177 bits (449), Expect = 9e-45, Method: Compositional matrix adjust. Identities = 131/469 (27%), Positives = 226/469 (48%), Gaps = 25/469 (5%) Query: 31 AFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDE 90 A P G +AT + + A AF W R ++ ++RE + E Sbjct: 32 ARSPLDGATLATLAVDTPADAERKIDAAHDAFLKWRTVPAPVRGELVRVFGNVLREHKAE 91 Query: 91 IATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHI--QLPGGSFGYTRREPLG 148 + + + GK E ++ ++ GL+ + G I + PG T P+G Sbjct: 92 LGRLVTLEAGKITSEGLGEVQEMIDICDFAVGLSRQLYGLTIASERPGHRMMETW-HPIG 150 Query: 149 VCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSAL----LLAEIYSE-----A 199 VC I A+N+P + +W +A A CG+++V+KPS TP++A+ LL + E Sbjct: 151 VCGVISAFNFPVAVWAWNAALAFVCGDSVVWKPSEKTPLTAIACHVLLQKALREFEKTHP 210 Query: 200 GVPPG-LFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGK 258 GV P L +V G G+ L V VS TGSV G ++ ++ ++ + LELGG Sbjct: 211 GVAPAELGQLVLGMRDVGEVLTASKKVPVVSATGSVRMGQEVAKVLSQRLARGILELGGN 270 Query: 259 SPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIG 318 + +I+ D++ V+ A T GQ C R+ V + ++++ + K +K+G Sbjct: 271 NGMIVAPSADLDLVVRAVTFAAVGTAGQRCTTLRRLIVHRSLVEQLLPRIEKAYASVKVG 330 Query: 319 DPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVL 378 +PL E T +GPL++R + + + A+EQG +V G + D D YY+RP ++ Sbjct: 331 NPLEEGTLVGPLVDRASFDAMQKALADAREQGGEVKGGERV----DVGHADAYYVRPAIV 386 Query: 379 TNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAEL 438 + V+ E F P++ ++ +D + ++ N GL++ +FT D++ A + ++ Sbjct: 387 RMPKQS-AVVERETFAPILYVMVYDNFDDAIDVHNAVPQGLSSAIFTNDMREAEQFMS-- 443 Query: 439 QAGT-CFINNYNV--SPVEL--PFGGYKKSGFGRENGRVTIEYYSQLKT 482 AG+ C I N N+ S E+ FGG K++G GRE+G + Y + T Sbjct: 444 AAGSDCGIVNVNIGTSGAEIGGAFGGEKETGGGRESGSDAWKAYMRRAT 492 >4H7N-A nrPDB Length = 474 Score = 174 bits (441), Expect = 7e-44, Method: Compositional matrix adjust. Identities = 122/399 (30%), Positives = 198/399 (49%), Gaps = 24/399 (6%) Query: 58 AKAAFKIWSQKSGME-RCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQC 116 A+ A W Q+ G+E R L + + I R +++ T +N+ + L+ID Sbjct: 37 ARRAQSRW-QELGVEGRITTLQQWKQAILSRREQL-TEALVNDTGRLSITVLEIDSFLAS 94 Query: 117 LEYYAGLAASM---AGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALAC 173 ++ + GLA + + ++ +P + + P + I WN+P ++ + PAL Sbjct: 95 IDRWCGLAPELLQTSAKNTSIPFIALQQSLV-PYPLVGVISPWNFPLTLSMIDTIPALLA 153 Query: 174 GNAMVFKPSPFTP--VSALLLAEIYSEAGVPPGLFNV---VQGGAATGQFLCQHPDVAKV 228 G A+V KPS P V+ LL+A P L +V V+GG TG L + D V Sbjct: 154 GCAVVVKPSEIAPRFVAPLLMA-----LNTVPELRDVLIFVEGGGETGANLINYVDF--V 206 Query: 229 SFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVC 288 FTGSV TG ++ E +A+ P LELGGK P I+ ++ A L + GQ C Sbjct: 207 CFTGSVATGREVAETAARRFIPAYLELGGKDPAIVLESANLELATSAILWGAVVNTGQSC 266 Query: 289 CNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKE 348 + R++V + ++F +++ + R+++ PL+ED +GP+I + + A E Sbjct: 267 LSIERIYVAESKFEEFYHQLIAKAHRLQLAYPLVEDGAIGPIIAEKQAGIINDHILDAVE 326 Query: 349 QGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEV 408 +GA + CGG + +L G++ RP V+TN M + EE FGP+M ++ F E Sbjct: 327 KGAVIHCGGKV-----EELGGGWWCRPTVMTNVNHSMKVMTEETFGPIMPVMPFPDVEEA 381 Query: 409 LERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN 447 + ANDT +GL+A VF A +V +L AG IN+ Sbjct: 382 VYLANDTIYGLSAAVFAGSEDEALKVARQLNAGAISIND 420 >4PXN-A nrPDB Length = 525 Score = 174 bits (441), Expect = 8e-44, Method: Compositional matrix adjust. Identities = 127/473 (26%), Positives = 214/473 (45%), Gaps = 21/473 (4%) Query: 28 TEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIRER 87 T + P +VIA + + ++ A K W +R I+ + +R + Sbjct: 52 TVTSTSPTNNQVIAEVVEASVHDYEEGMRACFDAAKTWMAIPAPKRGEIVRQIGDALRAK 111 Query: 88 EDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRRE-- 145 + + + GK + E ++ +Y GL+ + G I P + E Sbjct: 112 LHHLGRLVSLEMGKILPEGIGEVQEIIDMCDYAVGLSRQLNGSII--PSERPNHMMMEVW 169 Query: 146 -PLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSAL----LLAEIYSEAG 200 PLGV I A+N+P + W + AL CGN +V+K +P TP+ + ++A + + Sbjct: 170 NPLGVVGVITAFNFPCAVLGWNACIALVCGNCVVWKGAPTTPLITIAMTKIVASVLEKNN 229 Query: 201 VPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSP 260 +P +F GG GQ + + VSFTGS G+ + + + LEL G + Sbjct: 230 LPGAIFTSFCGGTEIGQAIALDIRIPLVSFTGSTRAGLMVQQQVSARFGKCLLELSGNNA 289 Query: 261 LIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDP 320 +I+ D D+ AV+ L A T GQ C R+ + + I F +++V+ ++++IGDP Sbjct: 290 IIVMDDADIQLAVRSVLFAAVGTAGQRCTTCRRLILHENIYQTFLDQLVEVYKQVRIGDP 349 Query: 321 LLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTN 380 L + T +GPL E L ++ K QG K+L GG E G +++P ++ Sbjct: 350 LEKGTLLGPLHTPASKENFLKGIQTIKSQGGKILFGGSAIESE------GNFVQPTIV-E 402 Query: 381 CRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQA 440 VKEE+FGPV+ ++ F T E +E N GL++ +FT+ + + Sbjct: 403 ITPSAPVVKEELFGPVLYVMKFQTLKEAIEINNSVPQGLSSSIFTKRPDIIFKWLGP-HG 461 Query: 441 GTCFINNYNV----SPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGD 489 C I N N+ + + FGG K +G GRE G + + Y + T + G Sbjct: 462 SDCGIVNVNIPTNGAEIGGAFGGEKATGGGREAGSDSWKQYMRRATCTINYGS 514 >4KNA-A nrPDB Length = 495 Score = 167 bits (423), Expect = 9e-42, Method: Compositional matrix adjust. Identities = 133/448 (29%), Positives = 200/448 (44%), Gaps = 31/448 (6%) Query: 34 PATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIAT 93 P T + + +V AV +A+ AF WS RC I+ A ++ ER++ +AT Sbjct: 31 PGTNERVWEGASASADDVERAVASARRAFAAWSALDLDARCTIVKRFAALLVERKEALAT 90 Query: 94 MECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGI 153 M GK ++EAR ++ ++ GE R P GV Sbjct: 91 MIGRETGKPLWEARTEVASMAAKVDISITAYHERTGEKRAPMADGVAVLRHRPHGVVAVF 150 Query: 154 GAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGA 213 G +N+P + + PAL GN +VFKPS P A EI+ +AG+P G+ N+VQG Sbjct: 151 GPYNFPGHLPNGHIVPALIAGNTVVFKPSELAPGVARATVEIWRDAGLPAGVLNLVQGEK 210 Query: 214 ATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKP---VTLELGGKSPLIIFSDCDMN 270 TG L H + + FTGS TG + + G +P + LE+GG +PL++ D++ Sbjct: 211 DTGVALANHRQIDGLFFTGSSDTGTLLHKQF--GGRPEIVLALEMGGNNPLVVAEVEDID 268 Query: 271 NAVKGALMANFLTQGQVCCNGTRVFVQKEIL-DKFTEEVVKQTQRIKI----GDPLLEDT 325 AV A+ + FL+ GQ C R+ V + D+F + +I DP Sbjct: 269 AAVHHAIQSAFLSAGQRCTCARRILVPRGAFGDRFVARLADVASKITASVFDADP---QP 325 Query: 326 RMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVP---EDPKLKDGYYMRPCVL--TN 380 MG +I+ R++ Q V G + DP L ++ +L TN Sbjct: 326 FMGAVISARAASRLVA------AQARLVGLGASPIIEMKQRDPALG---FVNAAILDVTN 376 Query: 381 CRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQA 440 R+ EE FGP+ I+ + + + RANDT FGL+AG+ D Q H ++A Sbjct: 377 VRE---LPDEEHFGPLAQIVRYTDLDDAIARANDTAFGLSAGLLADDEQAWHTFRRAIRA 433 Query: 441 GTCFINN-YNVSPVELPFGGYKKSGFGR 467 G N N + PFGG +SG R Sbjct: 434 GIVNWNRPTNGASSAAPFGGAGRSGNHR 461 >3SZA-A nrPDB Length = 469 Score = 166 bits (419), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 130/448 (29%), Positives = 212/448 (47%), Gaps = 24/448 (5%) Query: 46 SGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFE 105 S +++ AV+ A+AAF + R + L R+I+E+E E+ + K+ + Sbjct: 15 SHMSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWN 74 Query: 106 ARL-DIDISWQCLEYYAG----LAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPF 160 A ++ + +EY AA E Y EPLGV + IG WNYPF Sbjct: 75 AYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPF 134 Query: 161 QIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAA-TGQFL 219 + A+A GNA+V KPS + A LLA I + + L+ V+ GG T + L Sbjct: 135 NLTIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELL 193 Query: 220 CQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMA 279 + D + +TGS G IM +AK + PVTLELGGKSP + +CD++ A + Sbjct: 194 KERFD--HILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWG 251 Query: 280 NFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERV 339 F+ GQ C + I ++ E++ K + G+ + G +I+ H +RV Sbjct: 252 KFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRV 310 Query: 340 LGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSI 399 +G + +G KV GG D + Y+ P +LT+ ++EEIFGPV+ I Sbjct: 311 MGLI-----EGQKVAYGGT----GDAATR---YIAPTILTDVDPQSPVMQEEIFGPVLPI 358 Query: 400 LSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN--YNVSPVELPF 457 + + E ++ N LA +F+ + + +++AE +G N+ +++ LPF Sbjct: 359 VCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPF 418 Query: 458 GGYKKSGFGRENGRVTIEYYSQLKTVCV 485 GG SG G +G+ + E +S ++ V Sbjct: 419 GGVGNSGMGSYHGKKSFETFSHRRSCLV 446 >1AD3-A nrPDB Length = 452 Score = 162 bits (410), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 109/349 (31%), Positives = 173/349 (49%), Gaps = 19/349 (5%) Query: 141 YTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAG 200 Y EPLGV + IGAWNYPF + A+A GNA++ KPS + A LLA + + Sbjct: 98 YIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY- 156 Query: 201 VPPGLFNVVQGGA-ATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKS 259 + L+ VV+GG T + L + D + +TGS G +M +AK + PVTLELGGKS Sbjct: 157 MDQNLYLVVKGGVPETTELLKERFD--HIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKS 214 Query: 260 PLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGD 319 P + DCD++ A + F+ GQ C + I ++ E+ +K++ + G+ Sbjct: 215 PCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKDFYGE 273 Query: 320 PLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLT 379 + G +IN H +RV G + KV GG + Y+ P +L Sbjct: 274 DAKQSRDYGRIINDRHFQRVKGLI-----DNQKVAHGGTWD-------QSSRYIAPTILV 321 Query: 380 NCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQ 439 + ++EEIFGPVM I+ + E ++ N LA VF+ + + +++AE Sbjct: 322 DVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETS 381 Query: 440 AGTCFINN--YNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 486 +G N+ +++ LPFGG SG G +G+ + E +S ++ V+ Sbjct: 382 SGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVK 430 >4LGZ-A nrPDB Length = 563 Score = 155 bits (391), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 126/454 (27%), Positives = 218/454 (48%), Gaps = 34/454 (7%) Query: 40 IATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIR-EREDEIATMECIN 98 +A F + + +N A+ A AA K W K +R ++ L+AA ++ R E+ + Sbjct: 91 VAKFCYADKALLNRAIDAALAARKEWDLKPMADRAQVFLKAADMLSGPRRAEVLAKTMVG 150 Query: 99 NGKSIFEARLDIDISWQCLEYY---AGLAASMAGEH-IQLPGGSFGYTRREPLGVCVGIG 154 GK++ +A +ID + + ++++ A A + GE I +P + R G I Sbjct: 151 QGKTVIQA--EIDAAAELIDFFRFNAKFAVELEGEQPISVPPSTNHTVYRGLEGFVAAIS 208 Query: 155 AWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAA 214 +N+ + APAL GN +++KPS +++ + I EAG+PP + V Sbjct: 209 PFNFTAIGGNLAGAPAL-MGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGP 267 Query: 215 T-GQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTL------ELGGKSPLIIFSDC 267 T G + + ++FTGSVPT + A+ + E GGK+ + S Sbjct: 268 TFGDTVTSSEHLCGINFTGSVPTFKHLWRQVAQNLDRFRTFPRLAGECGGKNFHFVHSSA 327 Query: 268 DMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLED--T 325 D+++ V G L + F GQ C +R++V K + + ++++ RIK+GDP ED T Sbjct: 328 DVDSVVSGTLRSAFEYGGQKCSACSRLYVPKSLWPQIKGRLLEEHSRIKVGDP-AEDFGT 386 Query: 326 RMGPLINRPHLERVLGFVKVAKEQGA-KVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDD 384 +I+ R+ +++ A+ + +L GG GYY+ PC++ + Sbjct: 387 FFSAVIDAKAFARIKKWLEHARSSPSLSILAGGQC------NESVGYYVEPCIIESKDPQ 440 Query: 385 MTCVKEEIFGPVMSILSF--DTEAEVLERANDTT-FGLAAGVFTRD---IQRAHRVVAEL 438 +KEEIFGPV+++ + D E L+ + TT +GL VF +D +Q A R++ Sbjct: 441 EPIMKEEIFGPVLTVYVYPDDKYRETLKLVDSTTSYGLTGAVFAQDKAIVQEATRMLRN- 499 Query: 439 QAGTCFINNYNVSPV--ELPFGGYKKSGFGRENG 470 AG +IN+ + V + PFGG + SG + G Sbjct: 500 AAGNFYINDKSTGSVVGQQPFGGARASGTNDKPG 533 >4QGK-A nrPDB Length = 461 Score = 153 bits (387), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 122/440 (27%), Positives = 209/440 (47%), Gaps = 30/440 (6%) Query: 51 VNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARL-- 108 + L V+ + AF + R + L R+++ERE +I T + KS F Sbjct: 2 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 61 Query: 109 ------DIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQI 162 +ID + L + + A +++ L Y + +PLGV + IGAWNYPF + Sbjct: 62 VITVLGEIDFMLENLPEW--VTAKPVKKNV-LTMLDEAYIQPQPLGVVLIIGAWNYPFVL 118 Query: 163 ASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAA-TGQFLCQ 221 A+A GNA++ KPS + +A +LA++ + + L+ V+ GG T + L Q Sbjct: 119 TIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQ 177 Query: 222 HPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANF 281 D + +TG+ G +ME +AK + PVTLELGGKSP I DCD++ + + Sbjct: 178 RFD--HIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKY 235 Query: 282 LTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLG 341 + GQ C + + + ++ + +K+T + G+ + E +IN H +R+L Sbjct: 236 MNCGQTCIAPDYILCEASLQNQIVWK-IKETVKEFYGENIKESPDYERIINLRHFKRILS 294 Query: 342 FVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILS 401 + +G K+ GG+ D + Y+ P VLT+ ++EEIFGP++ I+ Sbjct: 295 LL-----EGQKIAFGGET----DEATR---YIAPTVLTDVDPKTKVMQEEIFGPILPIVP 342 Query: 402 FDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN--YNVSPVELPFGG 459 E + N+ LA VF+ + + R++ E +G N+ + + PFGG Sbjct: 343 VKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGG 402 Query: 460 YKKSGFGRENGRVTIEYYSQ 479 SG G +G+ + + +S Sbjct: 403 VGSSGMGAYHGKHSFDTFSH 422 >3V9H-A nrPDB Length = 566 Score = 152 bits (384), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 127/459 (27%), Positives = 220/459 (47%), Gaps = 38/459 (8%) Query: 37 GRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIR-EREDEIATME 95 G +A F + + +N A++ A AA K W K +R +I L+AA ++ R EI Sbjct: 91 GHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKT 150 Query: 96 CINNGKSIFEARLDIDISWQCLEYY---AGLAASMAGEH-IQLPGGSFGYTRREPLGVCV 151 + GK++ +A +ID + + ++++ A A + G+ I +P + R G Sbjct: 151 MVGQGKTVIQA--EIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVA 208 Query: 152 GIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG 211 I +N+ + APAL GN +++KPS +++ + I EAG+PP + V Sbjct: 209 AISPFNFTAIGGNLAGAPAL-MGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPA 267 Query: 212 -GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTL------ELGGKSPLIIF 264 G G + + ++FTGSVPT + + A+ + E GGK+ + Sbjct: 268 DGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVH 327 Query: 265 SDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLED 324 D+ + V G L + F GQ C R++V + + ++++ RIK+GDP ED Sbjct: 328 RSADVESVVSGTLRSAFEYGGQKCSACARLYVPHSLWPQIKGRLLEEHSRIKVGDP-AED 386 Query: 325 --TRMGPLINRPHLERVLGFVKVAKEQGA-KVLCGGDIYVPEDPKLKD--GYYMRPCVLT 379 T +I+ R+ +++ A+ + +L GG K D GY++ PC++ Sbjct: 387 FGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGG--------KCDDSVGYFVEPCIVE 438 Query: 380 NCRDDMTCVKEEIFGPVMSILSF--DTEAEVLERANDTT-FGLAAGVFTRD---IQRAHR 433 + +KEEIFGPV+S+ + D E L+ + TT +GL VF++D +Q A + Sbjct: 439 SKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATK 498 Query: 434 VVAELQAGTCFINNYNVSPV--ELPFGGYKKSGFGRENG 470 V+ AG +IN+ + + + PFGG + SG + G Sbjct: 499 VLRN-AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 536 >3JU8-A nrPDB Length = 490 Score = 150 bits (378), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 123/456 (26%), Positives = 207/456 (45%), Gaps = 35/456 (7%) Query: 28 TEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIRER 87 T ++ +P V+ + + +V+ AV A+ AF W+++ +R +L A ++ R Sbjct: 21 TLESLDPVGQGVVWSGRGADATQVDAAVCAAREAFPAWARRPLEQRIELLERFAATLKSR 80 Query: 88 EDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPL 147 DE+A + GK ++E+ ++ + GE + R +P Sbjct: 81 ADELARVIGEETGKPLWESATEVTSMVNKVAISVQAFRERTGEKSGPLADATAVLRHKPH 140 Query: 148 GVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFN 207 GV G +N+P + + PAL GN +VFKPS TP A L + + +AG+P G+ N Sbjct: 141 GVVAVFGPYNFPGHLPNGHIVPALLAGNCVVFKPSELTPKVAELTLKAWIQAGLPAGVLN 200 Query: 208 VVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIM-EMSAKGIKPVTLELGGKSPLIIFSD 266 +VQGG TG L H + + FTGS TG + + + K + LE+GG +PL++ Sbjct: 201 LVQGGRETGVALAAHRGLDGLFFTGSSRTGNLLHSQFGGQPQKILALEMGGNNPLVVEEV 260 Query: 267 CDMNNAVKGALMANFLTQGQVCCNGTRVFV-QKEILDKFTEEVVKQTQRIKIGD------ 319 D++ AV + + F++ GQ C R+ V Q D +V + +++G Sbjct: 261 ADLDAAVYTIIQSAFISAGQRCTCARRLLVPQGAWGDALLARLVAVSATLRVGRFDEQPA 320 Query: 320 PLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLT 379 P MG +I+ E +L K Q + G + + + P +L Sbjct: 321 PF-----MGAVISLSAAEHLL------KAQEHLIGKGAQPLLAMTQPIDGAALLTPGIL- 368 Query: 380 NCRDDMTCV----KEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVV 435 D++ V EE FGP++ ++ + A + AN T +GLAAG+ + +R + + Sbjct: 369 ----DVSAVAERPDEEFFGPLLQVIRYSDFAAAIREANATQYGLAAGLLSDSRERFEQFL 424 Query: 436 AELQAGTCFINNYNV----SPVELPFGGYKKSGFGR 467 E +AG I N+N + PFGG SG R Sbjct: 425 VESRAG---IVNWNKQLTGAASSAPFGGIGASGNHR 457 >5UCD-A nrPDB Length = 457 Score = 142 bits (357), Expect = 5e-34, Method: Compositional matrix adjust. Identities = 101/349 (28%), Positives = 166/349 (47%), Gaps = 22/349 (6%) Query: 141 YTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAG 200 Y +EP GV IG +NYP + A+ GN + KPS TP ++ ++ +I +EA Sbjct: 125 YVVQEPYGVTYIIGPFNYPVNLTLTPLIGAIIGGNTCIIKPSETTPETSAVIEKIIAEA- 183 Query: 201 VPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSP 260 P V+QGG L P + FTGS G +M+ +AK + PV LELGGK P Sbjct: 184 FAPEYVAVIQGGRDENSHLLSLP-FDFIFFTGSPNVGKVVMQAAAKHLTPVVLELGGKCP 242 Query: 261 LIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDP 320 LI+ D D++ V + F+ GQ ++V + D E +V +R+K P Sbjct: 243 LIVLPDADLDQTVNQLMFGKFINSGQTXIAPDYLYVHYSVKDALLERLV---ERVKTELP 299 Query: 321 LLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTN 380 + T G L+ ++R++ ++ + Q VL G V + + V+ Sbjct: 300 EINST--GKLVTERQVQRLVSLLEATQGQ---VLVGSQADVSKRA-------LSATVVDG 347 Query: 381 CRDDMTCVKEEIFGPVMSILSFDTEAEVLERAN-DTTFGLAAGVFTRDIQRAHRVVAELQ 439 + + EE+FGP++ +L FD+ +++ N LA VF +D+ A ++ ++Q Sbjct: 348 VEWNDPLMSEELFGPILPVLEFDSVRTAIDQVNKHHPKPLAVYVFGKDMDVAKGIINQIQ 407 Query: 440 AGTCFINN---YNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCV 485 +G +N + SP LPFGG SG G +G + ++ K+V + Sbjct: 408 SGDAQVNGVMLHAFSPY-LPFGGIGASGMGEYHGHFSYLTFTHKKSVRI 455 >5NNO-A nrPDB Length = 546 Score = 137 bits (346), Expect = 8e-33, Method: Compositional matrix adjust. Identities = 106/359 (29%), Positives = 169/359 (47%), Gaps = 35/359 (9%) Query: 145 EPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPG 204 EPLGV + IG WNYP + ALA GN V KPS P +A LL ++ + V Sbjct: 116 EPLGVVLVIGTWNYPLLLILQPLLGALAAGNTAVIKPSELAPATAELLTKLLPKY-VSSD 174 Query: 205 LFNVVQGGAA-TGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLII 263 + +V GG + T L + D + +TGS +M +AK + PVTLELGGKSP+++ Sbjct: 175 VVGIVNGGVSETTAVLKERFD--HILYTGSARVAEIVMAAAAKHLTPVTLELGGKSPVVV 232 Query: 264 FSDC--DMNNAVKGALMANFLTQGQVCCNGTRVFVQKE----ILDKFTE----------- 306 C +M + + + GQ V V+K ++D E Sbjct: 233 DDTCADNMKVVAERIMWGKIINAGQTSIAPDYVVVEKSMESVLVDALAEARKAMLGDKFL 292 Query: 307 EVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPK 366 +V+K +K LE++ ++N H +R++ F+K G KV GG+ ++ Sbjct: 293 KVLKGELLVKQKQQFLEESDYPRIVNASHFQRLMEFMK-----GGKVAVGGE---ADEAT 344 Query: 367 LKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTR 426 L + P +LTN ++EEIFGP++ +L+++ E ++L+ N LA VF+ Sbjct: 345 LT----IAPTILTNIDPTHPVMQEEIFGPILPVLTYENEKDILKIINSREKPLALYVFSN 400 Query: 427 DIQRAHRVVAELQAGT--CFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTV 483 + + V + +G + LPFGG +SG G +GR + E +S + V Sbjct: 401 NKRFIRGVESRTSSGAVVVNDVVVHAGADGLPFGGVGRSGMGAYHGRYSFETFSHRRPV 459 >4OE4-A nrPDB Length = 580 Score = 116 bits (290), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 124/476 (26%), Positives = 223/476 (46%), Gaps = 50/476 (10%) Query: 28 TEKAFEPATG-----RVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAAR 82 E+A P T +V+A T + EK+V AV+ AK A K W +R I L+AA Sbjct: 73 NERALFPQTNPANHQQVLANVTQATEKDVMNAVKAAKDAKKDWYNLPFYDRSAIFLKAAD 132 Query: 83 II--REREDEIATMECINNGKSIFEARLD-IDISWQCLEYYAGLAASM-AGEHIQLPGGS 138 +I + R D +A + GK++++A +D I YY A+ + A + ++ G+ Sbjct: 133 LISTKYRYDMLAAT-MLGQGKNVYQAEIDCITELSDFFRYYVKYASDLYAQQPVESADGT 191 Query: 139 FGYTRREPL-GVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYS 197 + PL G + +N+ A+ APAL GN +V+KPS +S LL + Sbjct: 192 WNKAEYRPLEGFVYAVSPFNFTAIAANLIGAPAL-MGNTVVWKPSQTAALSNYLLMTVLE 250 Query: 198 EAGVPPGLFNVVQGG--AATGQFLCQHPDVAKVSFTGS----------VPTGMKIMEMSA 245 EAG+P G+ N + G T Q L D + FTGS + +G ++E Sbjct: 251 EAGLPKGVINFIPGDPVQVTDQVLADK-DFGALHFTGSTNVFKSLYGKIQSG--VVEGKY 307 Query: 246 KGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFT 305 + + E GGK+ ++ ++++AV + F QGQ C +R+++ + ++F Sbjct: 308 RDYPRIIGETGGKNFHLVHPSANISHAVLSTIRGTFEFQGQKCSAASRLYLPESKSEEFL 367 Query: 306 EEV--VKQTQRI----KIGDPLLEDTR---MGPLINRPHLERVLGFVKVAKEQGA-KVLC 355 ++ + Q+Q + P+ MGP+I+ ++++ ++ AK+ ++L Sbjct: 368 SDMFGILQSQNVVPMNTSASPISGGNLRGFMGPVIHEQSFDKLVKVIEDAKKDPELEILY 427 Query: 356 GGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSF-DTE-AEVLERAN 413 GG G+++ P V+ R D + E FGP++++ + DTE E+ + + Sbjct: 428 GGQY------DKSQGWFVGPTVIKAKRPDHPYMSTEFFGPILTVYEYPDTEFNEICDIID 481 Query: 414 DTT-FGLAAGVFTRDIQRAHRVVAELQ--AGTCFINNYNVSPV--ELPFGGYKKSG 464 +T+ + L +F +D + +L+ AG +IN+ V + FGG + SG Sbjct: 482 NTSQYALTGAIFAKDRKAIEYADEKLKFSAGNFYINDKCTGAVVSQQWFGGARMSG 537 >4IDS-A nrPDB Length = 563 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 103/420 (24%), Positives = 177/420 (42%), Gaps = 31/420 (7%) Query: 65 WSQKSGMERCRILLEAARIIR-EREDEIATMECINNGKSIFEARLD-----IDISWQCLE 118 W+ ER + L AA ++ ++IA + KS+++A +D ID W+ Sbjct: 115 WAALPFDERAAVFLRAADLLAGPWREKIAAATMLGQSKSVYQAEIDAVCELIDF-WR--- 170 Query: 119 YYAGLAASMAGEHIQLPGGSFGYTRREPL-GVCVGIGAWNYPFQIASWKSAPALACGNAM 177 + A + + G + PL G I +N+ + +APAL GN + Sbjct: 171 FNVAFARQILEQQPISGPGEWNRIDYRPLDGFVYAITPFNFTSIAGNLPTAPAL-MGNTV 229 Query: 178 VFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPT 236 ++KPS ++A L ++ AG+PPG+ N+V G G A P +A + FTGS T Sbjct: 230 IWKPSITQTLAAYLTMQLLEAAGLPPGVINLVTGDGFAVSDVALADPRLAGIHFTGSTAT 289 Query: 237 GMKIMEMSAKGI------KPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCN 290 + + I + E GGK ++ + + + F QGQ C Sbjct: 290 FGHLWQWVGTNIGRYHSYPRLVGETGGKDFVVAHASARPDVLRTALIRGAFDYQGQKCSA 349 Query: 291 GTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQG 350 +R F+ + + +E++ + ++ GD G LI++ + + ++ AK Sbjct: 350 VSRAFIAHSVWQRMGDELLAKAAELRYGDITDLSNYGGALIDQRAFVKNVDAIERAKGAA 409 Query: 351 AKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSF-DTEAEVL 409 A + G Y +D +GY++RP VL + E FGP++S+ + D E + Sbjct: 410 AVTVAVGGEY--DD---SEGYFVRPTVLLSDDPTDESFVIEYFGPLLSVHVYPDERYEQI 464 Query: 410 ERANDT--TFGLAAGVFTRDIQRAHRVVAELQ--AGTCFINNYNVSPV--ELPFGGYKKS 463 DT + L V D Q + L+ AG ++N+ V PFGG + S Sbjct: 465 LDVIDTGSRYALTGAVIADDRQAVLTALDRLRFAAGNFYVNDKPTGAVVGRQPFGGARGS 524 >2Y53-A nrPDB Length = 534 Score = 95.5 bits (236), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 106/443 (23%), Positives = 191/443 (43%), Gaps = 49/443 (11%) Query: 33 EPATGRVIATFTCSG---EKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIRERED 89 +P TG + + G + + A ++ AA + + +R L + ++++ + Sbjct: 28 DPVTGVALVRVSSEGLDLARAFSFAREDGGAALRALTYA---QRAARLADIVKLLQAKRG 84 Query: 90 EIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPL-- 147 + + N+G + ++ +DID L YYA L AS+ H G + ++ Sbjct: 85 DYYAIATANSGTTRNDSAVDIDGGIFTLSYYAKLGASLGEVHALRDGSAESLSKDRSFSA 144 Query: 148 --------GVCVGIGAWNYPFQIASW----KSAPALACGNAMVFKPSPFTP-VSALLLAE 194 GV + I A+N+P SW K+APAL G ++ KP+ T ++ ++A+ Sbjct: 145 QHVLSPTRGVALFINAFNFP----SWGLWEKAAPALLSGVPVIVKPATATAWLTQRMVAD 200 Query: 195 IYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSA---KGIKPV 251 + +PPG +++ G +A L Q VSFTGS T + A +G + + Sbjct: 201 VVDAGILPPGALSIICGSSA--GLLDQIRSFDVVSFTGSADTAATLRAHPAFVQRGAR-L 257 Query: 252 TLELGGKSPLIIFSDCDMNNA-----VKGALMANFLTQGQVCCNGTRVFVQKEILDKFTE 306 ++ + I+ +D + +K + + GQ C R FV + L+ E Sbjct: 258 NVQADSLNSAILCADATPDTPAFDLFIKEVVREMTVKSGQKCTAIRRAFVPEAALEPVLE 317 Query: 307 EVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPE-DP 365 + + +I +G+P + RMG L++R E VL + +E+ VL VP D Sbjct: 318 ALKAKLAKITVGNPRNDAVRMGSLVSREQYENVLAGIAALREEA--VLAYDSSAVPLIDA 375 Query: 366 KLKDGYYMRPCV-LTNCRDDMTCVKE-EIFGPVMSILSF----DT----EAEVLERANDT 415 + P + + N D+ T + + E+FGPV S+ + DT EA + A Sbjct: 376 DANIAACVAPHLFVVNDPDNATLLHDVEVFGPVASVAPYRVTTDTNALPEAHAVALARRG 435 Query: 416 TFGLAAGVFTRDIQRAHRVVAEL 438 L A +++ D R+ EL Sbjct: 436 QGSLVASIYSNDDAHLGRLALEL 458 >3V4C-A nrPDB Length = 528 Score = 81.3 bits (199), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 110/429 (25%), Positives = 171/429 (39%), Gaps = 51/429 (11%) Query: 51 VNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIRERED---EIATMEC------IN--N 99 VN A + A+ AF + S ER L A I R + EI + E +N Sbjct: 65 VNRACEAAEEAFWTYGYSSRKERAAFLRAIADEIEARAEAITEIGSQETGLPEARLNGER 124 Query: 100 GKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYP 159 G++ + RL D + +Y + E P +R P+G GA N+P Sbjct: 125 GRTTGQLRLFAD-HIEKGDYLDRRVDAAMPERQPAPRQEIRLVQR-PVGPVAVFGASNFP 182 Query: 160 --FQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEA----GVPPGLFNVVQGGA 213 F A +A ALA G +V K P + ++AE A GV PG+F+++QGG+ Sbjct: 183 LAFSTAGGDTAAALAAGCPVVVKGHSAHPGTGEIVAEAVDAAIRKTGVHPGVFSLIQGGS 242 Query: 214 A-TGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTL--ELGGKSPLIIFSDCDMN 270 G L QHP + V FTGS+ G + ++ A +P+ ELG +P+ + + Sbjct: 243 RDVGHALVQHPHIKAVGFTGSLAGGRALFDLCAARPEPIPFFGELGSVNPMFLLPEALKA 302 Query: 271 NA-VKGALMANFLTQ--GQVCCN-GTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTR 326 A G A LT GQ C N G V ++ D+FT V+ ++ Sbjct: 303 RAETLGQGWAGSLTMGAGQFCTNPGIAVVIEGADADRFTTAAVEALAKVA---------- 352 Query: 327 MGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDM- 385 P G K ++ A+ + P G P + Sbjct: 353 -------PQTMLTDGIAKAYRDGQARFATRNAVK-PLLATESSGRDASPNLFETTGAQFL 404 Query: 386 --TCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTR--DIQRAHRV--VAELQ 439 + EE+FGP+ ++ + AE+ E A L A + D++ A R+ V E + Sbjct: 405 ADHALGEEVFGPLGLVVRVGSPAEMEELARGFQGQLTATIHMDAGDLETARRLRPVLERK 464 Query: 440 AGTCFINNY 448 AG +N + Sbjct: 465 AGRVLVNGF 473 >5UJU-A nrPDB Length = 576 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 66/289 (22%), Positives = 117/289 (40%), Gaps = 34/289 (11%) Query: 146 PLGVCVGIGAWNYPFQIASWKSAPAL----ACGNAMVFKPSP--FTP--VSALLLAEIYS 197 P G + +G +P +W P L A GN ++ KP P P ++ + ++ Sbjct: 204 PRGTGLVLGCCTFP----TWNGYPGLFADLATGNTVIVKPHPGAILPLAITVRIARDVLR 259 Query: 198 EAGVPPGLFNVVQGGAATG---QFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLE 254 EAG P + ++ G Q L P++ + FTGS G + + + V E Sbjct: 260 EAGFDPNVVTLLATEPNDGALVQDLALRPEIKLIDFTGSTQNGTWLERHAHQA--QVYTE 317 Query: 255 LGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKE---------ILDKFT 305 G + ++I S D+ A K + L GQ+C ++V ++ D+ Sbjct: 318 KAGVNQIVIDSTDDLKAAAKNIAFSLALYSGQMCTAPQNIYVPRDGIRTADGHASFDEVA 377 Query: 306 EEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDP 365 + + Q++ GDP +G + N + V + A+ G +L D + P Sbjct: 378 QAIAGAVQKL-TGDPARSVELIGAIQN----DGVTARIDAARAVGRVLL---DSQTLQHP 429 Query: 366 KLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERAND 414 D P VL D +E FGP+ +++ D+ A+ L+ A + Sbjct: 430 AFPDARVRTPLVLQLDVADREKFTQEWFGPISFVIATDSTAQSLDLAGE 478 >1EZ0-A nrPDB Length = 510 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 54/205 (26%), Positives = 90/205 (43%), Gaps = 21/205 (10%) Query: 147 LGVCVGIGAWNYP--FQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEA----G 200 LG GA N+P F A +A ALA G ++ K P ++ ++AE +A Sbjct: 137 LGPVAVFGASNFPLAFSAAGGDTASALAAGCPVIVKGHTAHPGTSQIVAECIEQALKQEQ 196 Query: 201 VPPGLFNVVQGGA-ATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTL--ELGG 257 +P +F ++QG A GQ L HP++ V FTGSV G + ++ + +P+ ELG Sbjct: 197 LPQAIFTLLQGNQRALGQALVSHPEIKAVGFTGSVGGGRALFNLAHERPEPIPFYGELGA 256 Query: 258 KSPLIIFSDCDMNNAVKGALMANFLTQ-----GQVCCNGTRVFV----QKEILDKFTEEV 308 +P IF K L F+ GQ C VF + + + + + Sbjct: 257 INPTFIFPSA---MRAKADLADQFVASMTMGCGQFCTKPGVVFALNTPETQAFIETAQSL 313 Query: 309 VKQTQRIKIGDPLLEDTRMGPLINR 333 ++Q + P + D+ +++R Sbjct: 314 IRQQSPSTLLTPGIRDSYQSQVVSR 338 >3MY7-A nrPDB Length = 452 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 53/195 (27%), Positives = 81/195 (41%), Gaps = 16/195 (8%) Query: 142 TRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSP----FTPVSALLLAEIYS 197 T EP+G+ GI P A +KS +L N ++F P P T +A L+ + Sbjct: 99 TIAEPVGIICGIVPTTNPTSTAIFKSLISLKTRNGIIFSPHPRAKNSTNDAAKLVLDAAV 158 Query: 198 EAGVPPGLFN-VVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELG 256 AG P + + Q L +H D+A + TG G +++ + KP Sbjct: 159 AAGAPKDIIGWIDQPSVELSNALMKHDDIALILATG----GPGMVKAAYSSGKPAIGVGA 214 Query: 257 GKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTE-------EVV 309 G P++I D+ AV LM+ G VC + V V E+ D+ E V+ Sbjct: 215 GNVPVVIDETADIKRAVASVLMSKTFDNGVVCASEQAVIVVDEVYDEVKERFASHKAHVL 274 Query: 310 KQTQRIKIGDPLLED 324 +T K+ LL D Sbjct: 275 SKTDADKVRKVLLID 289 >6D97-A nrPDB Length = 547 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 85/370 (22%), Positives = 137/370 (37%), Gaps = 48/370 (12%) Query: 101 KSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTR---REPLGVCVGIGAWN 157 KS +A ++ +S + LE + G +PG G R P G I +N Sbjct: 140 KSYQQALAEVQVSQKFLENFCGDQVRFLARSFAVPGNHLGQRSNGYRWPYGPVAIITPFN 199 Query: 158 YPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQ 217 +P +I + AL GN V K + + + + G+P + + A Sbjct: 200 FPLEIPLLQLMGALYMGNKPVLKVDSKVSIVMEQMIRLLHDCGLPAEDMDFINSDGAVMN 259 Query: 218 FLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIK-PVTLELGGKSPLIIFSDCDMNNAVKGA 276 L + FTGS ++ E A +K V LE G I+ D + V Sbjct: 260 KLLLEANPKMTLFTGS----SRVAEKLAADLKGRVKLEDAGFDWKILGPDVQEVDYVAWV 315 Query: 277 LMAN-FLTQGQVCCNGTRVFVQKEILDK-FTEEVVKQTQRIKIGDPLLEDTRMGPLINRP 334 + + GQ C + +F+ K E++ K ++R K LED +GP++ Sbjct: 316 CDQDAYACSGQKCSAQSVLFMHKNWSSSGLLEKMKKLSERRK-----LEDLTIGPVLTVT 370 Query: 335 HLERVLGFVKVAKEQGAKVLCGGD------------------IYVPEDPKLKDGYYMRPC 376 + + K +G+KVL GG+ ++VP + LK G Sbjct: 371 TEAMIEHMNNLLKIRGSKVLFGGEPLANHSIPKIYGAMKPTAVFVPLEEILKSG------ 424 Query: 377 VLTNCRDDMTCVKEEIFGP--VMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRV 434 + V +EIFGP V++ S D VLE L A + + D V Sbjct: 425 -------NFELVTKEIFGPFQVVTEYSEDQLELVLEACERMNAHLTAAIVSNDPLFLQDV 477 Query: 435 VAELQAGTCF 444 + GT + Sbjct: 478 LGRSVNGTTY 487 >5J7I-A nrPDB Length = 488 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 64/271 (23%), Positives = 110/271 (40%), Gaps = 16/271 (5%) Query: 49 KEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARL 108 +EV ++ AKAA KI + + E +I+ A RE +A M G E + Sbjct: 34 QEVRNYLEEAKAAQKILEKMTQSEIDKIVESMANAAREEAGRLAAMAVEETGFGNVEDKT 93 Query: 109 DIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSA 168 ++ + + Y + I+ + + +P+G+ GI P +K+ Sbjct: 94 LKNL-FAANDVYNSIKDVKTVGIIRRDEENRVWEIAQPVGIVAGIIPSTNPTSTVIFKAL 152 Query: 169 PALACGNAMVFKPSPF----TPVSALLLAEIYSEAGVPPGLFN-VVQGGAATGQFLCQHP 223 A+ NA+VF P P T +A ++ E AG P GL + + Q A L +H Sbjct: 153 IAVKARNAIVFSPHPSAAKCTAEAARIMQEAAERAGAPKGLISCITQPTMAATNELMKHK 212 Query: 224 DVAKVSFTGSVPTGMKIMEMSAK---GIKPVTLELGGKSPLIIFSDCDMNNAVKGALMAN 280 + TG P +K S K G+ P G P+ I ++ AV+ + + Sbjct: 213 LTDVILATGG-PGLVKAAYSSGKPAYGVGP------GNVPVYIHESANIAKAVQLIIQSK 265 Query: 281 FLTQGQVCCNGTRVFVQKEILDKFTEEVVKQ 311 G +C + + V + I +K E+ +Q Sbjct: 266 TFDYGTICASEQALLVDESIKEKVVAELKQQ 296 >3K9D-A nrPDB Length = 464 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 54/202 (26%), Positives = 81/202 (40%), Gaps = 26/202 (12%) Query: 146 PLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSE----AGV 201 PLGV G+ P +K+ ++ GN++VF P P + L I SE AG Sbjct: 108 PLGVVAGLIPSTNPTSTVIYKTLISIKAGNSIVFSPHPNALKAILETVRIISEAAEKAGC 167 Query: 202 PPGLFN-----VVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELG 256 P G + +QG T Q L +H D A + TG G +++ + P Sbjct: 168 PKGAISCMTVPTIQG---TDQ-LMKHKDTAVILATG----GSAMVKAAYSSGTPAIGVGP 219 Query: 257 GKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIK 316 G P I ++ AVK L + G +C + V V++ + E KQ Sbjct: 220 GNGPAFIERSANIPRAVKHILDSKTFDNGTICASEQSVVVERVNKEAVIAEFRKQ----- 274 Query: 317 IGDPLLED---TRMGPLINRPH 335 G L D ++G I RP+ Sbjct: 275 -GAHFLSDAEAVQLGKFILRPN 295 >5DBV-A nrPDB Length = 445 Score = 33.1 bits (74), Expect = 0.30, Method: Compositional matrix adjust. Identities = 46/234 (19%), Positives = 90/234 (38%), Gaps = 21/234 (8%) Query: 50 EVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLD 109 ++N A++ AK A + + S +R +I+ + E + +A M G Sbjct: 17 DMNQAIEAAKEAQLVVKKMSMDQREKIISAIRKKTIEHAETLARMAVEETGMG------- 69 Query: 110 IDISWQCLEYYAGLAASMAGEHIQLPG--GSFGYTRRE--PLGVCVGIGAWNYPFQIASW 165 ++ + L++ + E I G G T E P GV I P + Sbjct: 70 -NVGHKILKHQLVAEKTPGTEDITTTAWSGDRGLTLVEMGPFGVIGAITPCTNPSETIIC 128 Query: 166 KSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPG-----LFNVVQGGAATGQFLC 220 + LA GN +VF P P ++ ++ +EA + G +V + + + + Sbjct: 129 NTIGMLAGGNTVVFNPHPAAIKTSNFAVQLINEASLSAGGPVNIACSVRKPTLDSSKIMM 188 Query: 221 QHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVK 274 H D+ ++ TG +++ +GI G P+++ D+ A + Sbjct: 189 SHQDIPLIAATGGPGVVTAVLQSGKRGIGAG----AGNPPVLVDETADIRKAAE 238 >5JFN-A nrPDB Length = 524 Score = 32.7 bits (73), Expect = 0.38, Method: Compositional matrix adjust. Identities = 30/103 (29%), Positives = 41/103 (39%), Gaps = 7/103 (6%) Query: 137 GSFGYTRRE--PLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAE 194 G G T E P GV I P + S LA GN++VF P P +LLL Sbjct: 176 GDNGLTLVEYSPFGVIGAITPTTNPTETIVCNSIGMLAAGNSVVFSPHPRARQVSLLLVR 235 Query: 195 IYSEA----GVPPGLFNVVQGGA-ATGQFLCQHPDVAKVSFTG 232 + ++ G P L V+ + + HP V + TG Sbjct: 236 LINQKLAALGAPENLVVTVEKPSIENTNAMMAHPKVRMLVATG 278 >5AA6-A nrPDB Length = 597 Score = 32.0 bits (71), Expect = 0.64, Method: Compositional matrix adjust. Identities = 23/63 (36%), Positives = 32/63 (50%), Gaps = 2/63 (3%) Query: 429 QRAHRVVAELQAG-TCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 487 +R V EL G TC +NN + + + L G + KS + GRV E Y QL C+E Sbjct: 41 RRIGIAVGELAVGPTCHLNNGDEANIPLFDGQFHKSLPHDDMGRVNPEAY-QLLLDCIES 99 Query: 488 GDV 490 D+ Sbjct: 100 NDI 102 >4GDY-A nrPDB Length = 439 Score = 29.6 bits (65), Expect = 3.2, Method: Compositional matrix adjust. Identities = 26/100 (26%), Positives = 41/100 (41%), Gaps = 6/100 (6%) Query: 394 GPVMSILSFDTEAEVLERAND----TTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYN 449 G V + LS D + V+ RA+ + GL G T RV+ +Q T + +N Sbjct: 241 GRVPTFLSMDVDGRVI-RADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFN 299 Query: 450 VSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGD 489 + + + GF RV I++YS K + D Sbjct: 300 QLMISQLLHEWGEEGFMAHVDRV-IDFYSNQKDAILAAAD 338 >4JBE-A nrPDB Length = 445 Score = 28.9 bits (63), Expect = 5.2, Method: Compositional matrix adjust. Identities = 22/69 (31%), Positives = 31/69 (44%), Gaps = 5/69 (7%) Query: 397 MSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELP 456 +++ D AE + AN+ T GLAAG+ T D + A Q F N +P L Sbjct: 348 VTVARVDGVAEAVRIANEETSGLAAGIATEDARAAEEFFDGYQGTGVFWN----APTRL- 402 Query: 457 FGGYKKSGF 465 G+K G Sbjct: 403 LDGFKLLGV 411 >1XMM-B nrPDB Length = 342 Score = 28.1 bits (61), Expect = 9.2, Method: Compositional matrix adjust. Identities = 15/48 (31%), Positives = 23/48 (47%), Gaps = 2/48 (4%) Query: 427 DIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTI 474 D++ AH A + + N +PV LPF G++ RE+ R I Sbjct: 21 DVEEAH--AASTEEKEAGVGNGTCAPVRLPFSGFRLQKVLRESARDKI 66 >1ORD-A nrPDB Length = 730 Score = 28.1 bits (61), Expect = 9.3, Method: Compositional matrix adjust. Identities = 12/37 (32%), Positives = 22/37 (59%) Query: 393 FGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQ 429 F V ++++ D E +V++ A+ T FG+ T+D Q Sbjct: 30 FTDVGAVIAMDYETDVIDAADATKFGIPVFAVTKDAQ 66 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6QAO-A nrPDB 702 0.0 1BPW-A nrPDB 664 0.0 5AC2-A nrPDB 647 0.0 5AC0-A nrPDB 646 0.0 4X2Q-A nrPDB 633 0.0 5FHZ-A nrPDB 628 e-180 5L13-A nrPDB 626 e-180 1O9J-A nrPDB 622 e-178 1AG8-A nrPDB 618 e-177 5GT6-A nrPDB 610 e-175 4V3F-A nrPDB 608 e-174 4CAZ-A nrPDB 608 e-174 4O6R-A nrPDB 605 e-173 3R31-A nrPDB 591 e-169 4MPY-A nrPDB 587 e-168 4PZ2-A nrPDB 585 e-167 3IWK-A nrPDB 577 e-165 4PXL-B nrPDB 577 e-165 4GO4-A nrPDB 576 e-165 3JZ4-A nrPDB 569 e-163 3IWJ-A nrPDB 569 e-162 2D4E-A nrPDB 565 e-161 3RHO-A nrPDB 564 e-161 4I8Q-A nrPDB 560 e-160 4I8P-A nrPDB 559 e-160 5KLK-A nrPDB 551 e-157 4QYJ-A nrPDB 549 e-157 4O5H-A nrPDB 542 e-154 6B4R-B nrPDB 542 e-154 5IUV-A nrPDB 541 e-154 5J77-A nrPDB 537 e-153 4V6H-A nrPDB 536 e-153 4U3W-A nrPDB 526 e-150 2HG2-A nrPDB 524 e-149 3TY7-A nrPDB 522 e-148 3EK1-A nrPDB 522 e-148 3K2W-A nrPDB 519 e-148 1WNB-A nrPDB 517 e-147 6C43-A nrPDB 515 e-146 1T90-A nrPDB 512 e-145 5EUY-A nrPDB 511 e-145 3U4J-A nrPDB 510 e-145 4F3X-A nrPDB 508 e-144 3I44-A nrPDB 505 e-143 4LIH-A nrPDB 505 e-143 2W8P-A nrPDB 499 e-141 3QAN-A nrPDB 498 e-141 5TJR-A nrPDB 493 e-140 5X5U-A nrPDB 492 e-139 4ZZ7-A nrPDB 492 e-139 3RJL-A nrPDB 492 e-139 3B4W-A nrPDB 490 e-139 5VBF-A nrPDB 490 e-139 4JZ6-A nrPDB 487 e-138 3RH9-A nrPDB 487 e-138 3RHD-A nrPDB 484 e-137 2JG7-A nrPDB 482 e-136 4YWE-A nrPDB 476 e-135 4X0T-A nrPDB 475 e-134 4DNG-A nrPDB 475 e-134 2QE0-A nrPDB 475 e-134 6FK3-A nrPDB 474 e-134 3VZ3-A nrPDB 473 e-134 6MVR-A nrPDB 471 e-133 3EFV-A nrPDB 468 e-132 3ROS-A nrPDB 467 e-132 3R64-A nrPDB 465 e-131 3VZ0-A nrPDB 465 e-131 4PXN-A nrPDB 464 e-131 5UR2-A nrPDB 463 e-130 4OGD-A nrPDB 461 e-130 3PRL-A nrPDB 459 e-129 5N5S-A nrPDB 455 e-128 4E4G-A nrPDB 453 e-127 5KF0-A nrPDB 448 e-126 5JRY-A nrPDB 442 e-124 2J5N-A nrPDB 440 e-124 5J6B-A nrPDB 438 e-123 5U0M-A nrPDB 428 e-120 6DBB-A nrPDB 419 e-117 3SZA-A nrPDB 417 e-117 1UXV-A nrPDB 412 e-115 3JU8-A nrPDB 408 e-114 4KNA-A nrPDB 403 e-112 3V9H-A nrPDB 393 e-110 4I3V-A nrPDB 393 e-109 1AD3-A nrPDB 392 e-109 4LGZ-A nrPDB 391 e-109 4QGK-A nrPDB 383 e-106 4H7N-A nrPDB 379 e-105 4OE4-A nrPDB 364 e-101 5UCD-A nrPDB 350 7e-97 4IDS-A nrPDB 322 3e-88 5NNO-A nrPDB 309 2e-84 2Y53-A nrPDB 267 1e-71 3V4C-A nrPDB 252 3e-67 6D97-A nrPDB 244 7e-65 5J7I-A nrPDB 202 3e-52 1EZ0-A nrPDB 193 1e-49 5UJU-A nrPDB 187 1e-47 3K9D-A nrPDB 170 9e-43 3MY7-A nrPDB 168 3e-42 Sequences not found previously or not previously below threshold: 5DBV-A nrPDB 159 2e-39 5JFN-A nrPDB 133 1e-31 1O20-A nrPDB 110 2e-24 4JBE-A nrPDB 93 3e-19 4GHK-A nrPDB 88 6e-18 1VLU-A nrPDB 72 7e-13 2H5G-A nrPDB 69 5e-12 5A0V-A nrPDB 39 0.004 1PDZ-A nrPDB 36 0.040 4YIF-A nrPDB 35 0.079 1NNE-A nrPDB 34 0.16 1EWR-A nrPDB 34 0.17 3BA0-A nrPDB 33 0.25 1JIZ-A nrPDB 33 0.36 1V9N-A nrPDB 33 0.43 2PA6-A nrPDB 32 0.66 3B97-A nrPDB 32 0.73 3LOO-A nrPDB 31 1.0 2CUN-A nrPDB 31 1.1 5WRO-A nrPDB 31 1.3 6AHD-9 nrPDB 31 1.3 3DOD-A nrPDB 31 1.4 1SU3-A nrPDB 31 1.7 1FBL-A nrPDB 31 1.7 5MMM-i nrPDB 31 1.8 5J6F-A nrPDB 30 2.2 3TSB-A nrPDB 30 2.4 2R6F-A nrPDB 30 2.8 3WUY-A nrPDB 29 3.8 4G5X-A nrPDB 29 3.9 3UX8-A nrPDB 29 3.9 3R11-A nrPDB 29 4.0 1EAK-A nrPDB 29 4.1 1CK7-A nrPDB 29 4.1 2Q9B-A nrPDB 29 4.7 3IWA-A nrPDB 29 4.9 4XFE-A nrPDB 29 5.2 1QIB-A nrPDB 29 5.4 3TFC-A nrPDB 29 5.6 2IPH-A nrPDB 29 6.8 6C0F-8 nrPDB 28 7.3 4ILK-A nrPDB 28 7.9 >6QAO-A nrPDB Length = 508 Score = 702 bits (1812), Expect = 0.0, Method: Composition-based stats. Identities = 494/494 (100%), Positives = 494/494 (100%) Query: 1 MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA 60 MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA Sbjct: 15 MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA 74 Query: 61 AFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYY 120 AFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYY Sbjct: 75 AFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYY 134 Query: 121 AGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFK 180 AGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFK Sbjct: 135 AGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFK 194 Query: 181 PSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKI 240 PSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKI Sbjct: 195 PSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKI 254 Query: 241 MEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEI 300 MEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEI Sbjct: 255 MEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEI 314 Query: 301 LDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY 360 LDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY Sbjct: 315 LDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY 374 Query: 361 VPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA 420 VPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA Sbjct: 375 VPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA 434 Query: 421 AGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQL 480 AGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQL Sbjct: 435 AGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQL 494 Query: 481 KTVCVEMGDVESAF 494 KTVCVEMGDVESAF Sbjct: 495 KTVCVEMGDVESAF 508 >1BPW-A nrPDB Length = 503 Score = 664 bits (1713), Expect = 0.0, Method: Composition-based stats. Identities = 348/493 (70%), Positives = 416/493 (84%) Query: 2 STGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAA 61 STG+ VV+ LNY GG R++ D + TE FEPATGRV+ G +EV+ AVQ+A+AA Sbjct: 11 STGSVVVTDDLNYWGGRRIKSKDGATTEPVFEPATGRVLCQMVPCGAEEVDQAVQSAQAA 70 Query: 62 FKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYA 121 + WS+ +G+ER R++LEAARIIRER D IA +E INNGK+I EA DID +WQC+EYYA Sbjct: 71 YLKWSKMAGIERSRVMLEAARIIRERRDNIAKLEVINNGKTITEAEYDIDAAWQCIEYYA 130 Query: 122 GLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKP 181 GLA +++G+HIQLPGG+F YTRREPLGVC GI AWNYPF IA+WK APALACGNA+VFKP Sbjct: 131 GLAPTLSGQHIQLPGGAFAYTRREPLGVCAGILAWNYPFMIAAWKCAPALACGNAVVFKP 190 Query: 182 SPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIM 241 SP TPV+ ++LAEI+ EAGVP GL NVVQGGA TG LC HP+VAKVSFTGSVPTG K+M Sbjct: 191 SPMTPVTGVILAEIFHEAGVPVGLVNVVQGGAETGSLLCHHPNVAKVSFTGSVPTGKKVM 250 Query: 242 EMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEIL 301 EMSAK +K VTLELGGKSPL+IF DC++ NAV+GALMANFLTQGQVC NGTRVFVQ+EI+ Sbjct: 251 EMSAKTVKHVTLELGGKSPLLIFKDCELENAVRGALMANFLTQGQVCTNGTRVFVQREIM 310 Query: 302 DKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYV 361 +F EEVVK+T+ I +GDPLL +TRMG LI++P L++VLGFV AK++GA+VLCGG+ Sbjct: 311 PQFLEEVVKRTKAIVVGDPLLTETRMGGLISKPQLDKVLGFVAQAKKEGARVLCGGEPLT 370 Query: 362 PEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAA 421 P DPKLK+GY+M PCVL NCRDDMTCVKEEIFGPVMS+L FDTE EVL+RAN+TTFGLA+ Sbjct: 371 PSDPKLKNGYFMSPCVLDNCRDDMTCVKEEIFGPVMSVLPFDTEEEVLQRANNTTFGLAS 430 Query: 422 GVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLK 481 GVFTRDI RAHRV A L+AGTC+IN Y++SPVE+PFGGYK SGFGRENG+ T++YYSQLK Sbjct: 431 GVFTRDISRAHRVAANLEAGTCYINTYSISPVEVPFGGYKMSGFGRENGQATVDYYSQLK 490 Query: 482 TVCVEMGDVESAF 494 TV VEMGDV+S F Sbjct: 491 TVIVEMGDVDSLF 503 >5AC2-A nrPDB Length = 501 Score = 647 bits (1669), Expect = 0.0, Method: Composition-based stats. Identities = 192/494 (38%), Positives = 281/494 (56%), Gaps = 12/494 (2%) Query: 5 TFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI 64 T + Q + + F PAT + +++V+ AV+ A+ AF+I Sbjct: 14 TDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQI 73 Query: 65 ---WSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARL-DIDISWQCLEYY 120 W ER R+L + A +I +ATME +N GK A L D+ + L Y Sbjct: 74 GSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYC 133 Query: 121 AGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFK 180 AG A + G I + G F YTR EP+GVC I WN+P + WK PAL+CGN +V K Sbjct: 134 AGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVK 193 Query: 181 PSPFTPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMK 239 P+ TP++AL +A + EAG PPG+ N+V G G G + H D+ KV+FTGS G Sbjct: 194 PAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKL 253 Query: 240 IMEMSAK-GIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQK 298 I E + K +K VTLELGGKSP I+ +D D++NAV+ A F QGQ C +R+FV++ Sbjct: 254 IKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEE 313 Query: 299 EILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGD 358 I D+F V++ ++ +G+PL GP I++ +++L ++ K++GAK+ CGG Sbjct: 314 SIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGG 373 Query: 359 IYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFG 418 P GY+++P V +N D+M KEEIFGPV I+ F + +V++RAN+T +G Sbjct: 374 ------PWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYG 427 Query: 419 LAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYS 478 L+AGVFT+DI +A + + LQAGT ++N Y V + PFGG+K SG GRE G Y+ Sbjct: 428 LSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYT 487 Query: 479 QLKTVCVEMGDVES 492 ++KTV V++ S Sbjct: 488 EVKTVTVKISQKNS 501 >5AC0-A nrPDB Length = 501 Score = 646 bits (1667), Expect = 0.0, Method: Composition-based stats. Identities = 189/485 (38%), Positives = 279/485 (57%), Gaps = 13/485 (2%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI---WSQKSG 70 + + + F PAT + +++V+ AV+ A+ AF+I W Sbjct: 24 FINNEW-HSSVSGKKFPVFNPATEEKLCEVEEGDKEDVDKAVKAARQAFQIGSPWRTMDA 82 Query: 71 MERCRILLEAARIIREREDEIATMECINNGKSIFEARL-DIDISWQCLEYYAGLAASMAG 129 ER R+L + A +I +ATME +N GK A L D+ + L Y AG A + G Sbjct: 83 SERGRLLNKLADLIERDRLLLATMEAMNGGKLFSNAYLMDLGGCIKTLRYCAGWADKIQG 142 Query: 130 EHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSA 189 I + G F YTR EP+GVC I WN+P + WK PAL+CGN +V KP+ TP++A Sbjct: 143 RTIPMDGNFFTYTRSEPVGVCGQIIPWNFPLLMFLWKIGPALSCGNTVVVKPAEQTPLTA 202 Query: 190 LLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK-G 247 L + + EAG PPG+ N+V G G G + H DV KV+FTGS G I E + K Sbjct: 203 LHMGSLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVDKVAFTGSTEVGKLIKEAAGKSN 262 Query: 248 IKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEE 307 +K V+LELGGKSP I+F+D D++NAV+ A F QGQ C +R+FV++ I D+F Sbjct: 263 LKRVSLELGGKSPCIVFADADLDNAVEFAHQGVFYHQGQCCIAASRLFVEESIYDEFVRR 322 Query: 308 VVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKL 367 V++ ++ +G+PL GP I++ E++L ++ K++GAK+ CGG P Sbjct: 323 SVERAKKYVLGNPLTPGVSQGPQIDKEQYEKILDLIESGKKEGAKLECGGG------PWG 376 Query: 368 KDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRD 427 GY+++P V ++ DDM KEEIFGPV I+ F + +V++RAN+T +GL+AG+FT D Sbjct: 377 NKGYFIQPTVFSDVTDDMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGIFTND 436 Query: 428 IQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 487 I +A V + LQ+GT ++N Y+V + PFGG+K SG GRE G Y+++KTV +++ Sbjct: 437 IDKAITVSSALQSGTVWVNCYSVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTIKI 496 Query: 488 GDVES 492 S Sbjct: 497 SQKNS 501 >4X2Q-A nrPDB Length = 504 Score = 633 bits (1634), Expect = 0.0, Method: Composition-based stats. Identities = 188/485 (38%), Positives = 276/485 (56%), Gaps = 13/485 (2%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFK---IWSQKSG 70 + + +++ + PATG + + + +++ AVQ A+ AF +W + Sbjct: 27 FINNEW-QNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDA 85 Query: 71 MERCRILLEAARIIREREDEIATMECINNGKSIFEA-RLDIDISWQCLEYYAGLAASMAG 129 ER R+L + A ++ +ATME +N GK +A +D+ + YYAG A + G Sbjct: 86 SERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHG 145 Query: 130 EHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSA 189 I + G F +TR EP+GVC I WN+P + +WK APAL CGN +V KP+ TP+SA Sbjct: 146 MTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSA 205 Query: 190 LLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK-G 247 L + + EAG PPG+ N++ G G G + H + K++FTGS G I E + + Sbjct: 206 LYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSN 265 Query: 248 IKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEE 307 +K VTLELGGKSP IIF+D D++ AV+ A F QGQ C G+R+FV++ I ++F Sbjct: 266 LKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRR 325 Query: 308 VVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKL 367 V++ +R +G P T GP I++ ++L ++ +GAK+ CGG Sbjct: 326 SVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLG------ 379 Query: 368 KDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRD 427 + G+++ P V +N DDM KEEIFGPV IL F T EV+ERAN++ FGL A VFT D Sbjct: 380 RKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTND 439 Query: 428 IQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 487 I +A V + +QAGT +IN YN + PFGG+K SG GRE G + YS++KTV V++ Sbjct: 440 INKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKI 499 Query: 488 GDVES 492 S Sbjct: 500 PQKNS 504 >5FHZ-A nrPDB Length = 529 Score = 628 bits (1619), Expect = e-180, Method: Composition-based stats. Identities = 171/485 (35%), Positives = 271/485 (55%), Gaps = 13/485 (2%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI---WSQKSG 70 + + + P+T I + +V+ AV+ A+ AF+ W + Sbjct: 52 FINNEW-HESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDA 110 Query: 71 MERCRILLEAARIIREREDEIATMECINNGKSIFEAR-LDIDISWQCLEYYAGLAASMAG 129 + R R+L + A ++ +A +E ++ GK A +D++ + L Y+AG A + G Sbjct: 111 LSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQG 170 Query: 130 EHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSA 189 + I +TR EP+GVC I WN+P + WK APAL CGN MV KP+ TP++A Sbjct: 171 KTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTA 230 Query: 190 LLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK-G 247 L L + EAG PPG+ N+V G G G + HP + K++FTGS G + E +++ Sbjct: 231 LYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSN 290 Query: 248 IKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEE 307 +K VTLELGGK+P I+ +D D++ AV+ A F QGQ C +RVFV++++ +F Sbjct: 291 LKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRR 350 Query: 308 VVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKL 367 V+ ++ +GDP T GP I++ +++L ++ K++GAK+ CGG Sbjct: 351 SVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAM------E 404 Query: 368 KDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRD 427 G +++P V + D+M KEEIFGPV IL F + EV++RAN T +GL A VFT++ Sbjct: 405 DKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKN 464 Query: 428 IQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 487 + +A ++ + L++GT +IN YN + PFGG+K SG GRE G + Y+++KTV +++ Sbjct: 465 LDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKL 524 Query: 488 GDVES 492 GD Sbjct: 525 GDKNP 529 >5L13-A nrPDB Length = 517 Score = 626 bits (1616), Expect = e-180, Method: Composition-based stats. Identities = 201/485 (41%), Positives = 286/485 (58%), Gaps = 13/485 (2%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFK---IWSQKSG 70 + A + T P+TG VI +++V+ AV+ A+AAF+ W + Sbjct: 40 FINNEW-HDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDA 98 Query: 71 MERCRILLEAARIIREREDEIATMECINNGKSIFEAR-LDIDISWQCLEYYAGLAASMAG 129 R R+L A +I +A +E ++NGK + +D+D+ +CL YYAG A G Sbjct: 99 SHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHG 158 Query: 130 EHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSA 189 + I + G F YTR EP+GVC I WN+P + +WK PALA GN +V K + TP++A Sbjct: 159 KTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTA 218 Query: 190 LLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK-G 247 L +A + EAG PPG+ N+V G G G + H DV KV+FTGS G I + Sbjct: 219 LYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSN 278 Query: 248 IKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEE 307 +K VTLELGGKSP II SD DM+ AV+ A A F QGQ CC G+R FVQ++I D+F E Sbjct: 279 LKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVER 338 Query: 308 VVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKL 367 V + + +G+P T GP ++ +++LG++ K++GAK+LCGG I Sbjct: 339 SVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADR---- 394 Query: 368 KDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRD 427 GY+++P V + +D MT KEEIFGPVM IL F T EV+ RAN++T+GLAA VFT+D Sbjct: 395 --GYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKD 452 Query: 428 IQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 487 + +A+ + LQAGT ++N Y+V + PFGGYK SG GRE G ++ Y+++KTV V++ Sbjct: 453 LDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKV 512 Query: 488 GDVES 492 S Sbjct: 513 PQKNS 517 >1O9J-A nrPDB Length = 501 Score = 622 bits (1604), Expect = e-178, Method: Composition-based stats. Identities = 189/494 (38%), Positives = 282/494 (57%), Gaps = 12/494 (2%) Query: 5 TFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI 64 T + Q + + T F PAT I + +++V+ AV+ A+ AF++ Sbjct: 14 TNIKIQHTKLFINNEWHESVSGKTFPVFNPATEEKICEVEEADKEDVDKAVKAAREAFQM 73 Query: 65 ---WSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARL-DIDISWQCLEYY 120 W ER +++ + A +I +AT+E IN GK A L D+D + L Y Sbjct: 74 GSPWRTMDASERGQLIYKLADLIERDRLLLATLESINAGKVFASAYLMDLDYCIKALRYC 133 Query: 121 AGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFK 180 AG A + G I + G F YTR EP+GVC I WN P + + K PAL CGN ++ K Sbjct: 134 AGWADKIQGRTIPVDGEFFSYTRHEPIGVCGLIFPWNAPMILLACKIGPALCCGNTVIVK 193 Query: 181 PSPFTPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMK 239 P+ TP++AL +A + EAG PPG+ N+V G G G + H DV KV+FTGS G Sbjct: 194 PAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVDKVAFTGSTEVGKM 253 Query: 240 IMEMSAK-GIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQK 298 I E +AK +K VTLELG K+P I+F+D D+++AV+ A F QGQ C +++FV++ Sbjct: 254 IQEAAAKSNLKRVTLELGAKNPCIVFADADLDSAVEFAHQGVFTNQGQSCIAASKLFVEE 313 Query: 299 EILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGD 358 I D+F + V++ ++ G+PL GP IN+ +++ ++ K++GAK+ CGG Sbjct: 314 AIYDEFVQRSVERAKKYVFGNPLTPGVNHGPQINKAQHNKIMELIESGKKEGAKLECGGG 373 Query: 359 IYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFG 418 P GY+++P V +N DDM KEEIFGPV I+ F + EV++RAN+T +G Sbjct: 374 ------PWGNKGYFIQPTVFSNVTDDMRIAKEEIFGPVQQIMKFKSLDEVIKRANNTYYG 427 Query: 419 LAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYS 478 L AGVFT+D+ +A V + LQAGT ++N Y + + P GG+K SG GRE G I Y+ Sbjct: 428 LVAGVFTKDLDKAVTVSSALQAGTVWVNCYLAASAQSPAGGFKMSGHGREMGEYGIHEYT 487 Query: 479 QLKTVCVEMGDVES 492 ++KTV +++ + S Sbjct: 488 EVKTVTMKISEKNS 501 >1AG8-A nrPDB Length = 499 Score = 618 bits (1595), Expect = e-177, Method: Composition-based stats. Identities = 200/485 (41%), Positives = 283/485 (58%), Gaps = 13/485 (2%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFK---IWSQKSG 70 + A + T P+TG VI + +V+ AV+ A+AAF+ W + Sbjct: 22 FINNEW-HDAVSKKTFPTVNPSTGDVICHVAEGDKADVDRAVKAARAAFQLGSPWRRMDA 80 Query: 71 MERCRILLEAARIIREREDEIATMECINNGKSIFEAR-LDIDISWQCLEYYAGLAASMAG 129 ER R+L A +I +A +E ++NGK + +D+D+ +CL YYAG A G Sbjct: 81 SERGRLLNRLADLIERDRTYLAALETLDNGKPYIISYLVDLDMVLKCLRYYAGWADKYHG 140 Query: 130 EHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSA 189 + I + G F YTR EP+GVC I WN+P + +WK PALA GN +V K + TP++A Sbjct: 141 KTIPIDGDYFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTA 200 Query: 190 LLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK-G 247 L +A + EAG PPG+ NV+ G G G + H DV KV+FTGS G I + K Sbjct: 201 LYVANLIKEAGFPPGVVNVIPGFGPTAGAAIASHEDVDKVAFTGSTEVGHLIQVAAGKSN 260 Query: 248 IKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEE 307 +K VTLE+GGKSP II SD DM+ AV+ A A F QGQ CC G+R FVQ++I +F E Sbjct: 261 LKRVTLEIGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYAEFVER 320 Query: 308 VVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKL 367 V + + +G+P T GP ++ ++VLG++K KE+G K+LCGG Sbjct: 321 SVARAKSRVVGNPFDSRTEQGPQVDETQFKKVLGYIKSGKEEGLKLLCGGG------AAA 374 Query: 368 KDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRD 427 GY+++P V + +D MT KEEIFGPVM IL F + EV+ RAN++ +GLAA VFT+D Sbjct: 375 DRGYFIQPTVFGDLQDGMTIAKEEIFGPVMQILKFKSMEEVVGRANNSKYGLAAAVFTKD 434 Query: 428 IQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 487 + +A+ + LQAGT ++N Y+V + PFGGYK SG GRE G ++ Y+++KTV V + Sbjct: 435 LDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKLSGSGRELGEYGLQAYTEVKTVTVRV 494 Query: 488 GDVES 492 S Sbjct: 495 PQKNS 499 >5GT6-A nrPDB Length = 508 Score = 610 bits (1573), Expect = e-175, Method: Composition-based stats. Identities = 195/486 (40%), Positives = 295/486 (60%), Gaps = 11/486 (2%) Query: 6 FVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI- 64 F+ + + G V A T + + PAT V+A + E++++ AV+ A++AF+ Sbjct: 29 FLNEEIKMFINGEFV-SAIGGKTFETYNPATEDVLAVVCEAQEEDIDAAVKAARSAFESG 87 Query: 65 -WSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLD-IDISWQCLEYYAG 122 W++ + ER ++ + A +I E +E+A +E ++NGK A D I + + YYAG Sbjct: 88 PWAEMTTAERAHLIYKLADLIEEHREELAQLEALDNGKPYQVALDDDISATVENYRYYAG 147 Query: 123 LAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPS 182 + G+ I + YTR EP+GV I WN+P ++SWK ALA G +V KP+ Sbjct: 148 WTTKIIGQTIPISKDYLNYTRHEPVGVVGQIIPWNFPLVMSSWKMGAALATGCTIVLKPA 207 Query: 183 PFTPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIM 241 TP+S L A+++ EAG P G+ N V G G G + H D+ KV+FTGS TG IM Sbjct: 208 EQTPLSLLYAAKLFKEAGFPNGVVNFVPGFGPEAGAAIVNHHDIDKVAFTGSTVTGKYIM 267 Query: 242 EMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEIL 301 SA+ IK VTLELGGKSP II D D+ A+ GA GQ C G+RVFV ++ Sbjct: 268 RQSAEMIKHVTLELGGKSPNIILEDADLEEAINGAFQGIMYNHGQNCSAGSRVFVHRKHY 327 Query: 302 DKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYV 361 + + +VK +K+G + ++T MGPL+++ ERVL +++ K++GA V GG+ Sbjct: 328 ETVVDALVKMANNVKLGAGMEKETEMGPLVSKKQQERVLNYIEQGKKEGATVAAGGER-- 385 Query: 362 PEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAA 421 L+ GY+++P V T+ DDMT VKEEIFGPV+ +L FD+ EV+ERAN++++GLAA Sbjct: 386 ----ALEKGYFVKPTVFTDVTDDMTIVKEEIFGPVVVVLPFDSTEEVIERANNSSYGLAA 441 Query: 422 GVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLK 481 GV+T++I+ H+V +L+AGT +IN+YN+ PFGGYK+SG GRE G ++ Y+++K Sbjct: 442 GVWTQNIKTGHQVANKLKAGTVWINDYNLENAAAPFGGYKQSGIGRELGSYALDNYTEVK 501 Query: 482 TVCVEM 487 +V V + Sbjct: 502 SVWVNI 507 >4V3F-A nrPDB Length = 497 Score = 608 bits (1568), Expect = e-174, Method: Composition-based stats. Identities = 189/485 (38%), Positives = 278/485 (57%), Gaps = 12/485 (2%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI--WSQKSGM 71 + G EP + P+T +I + ++V +AV A+ AF+ WS SG Sbjct: 11 FIDGEWREPIKKNR-IPVINPSTEEIIGDIPAATAEDVEVAVVAARRAFRRNNWSATSGA 69 Query: 72 ERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGE- 130 R L A I E++D +E I++GK EA LDID C EY+AG A ++ G+ Sbjct: 70 HRATYLRAIAAKITEKKDHFVKLETIDSGKPFDEAVLDIDDVASCFEYFAGQAEALDGKQ 129 Query: 131 --HIQLPGGSF-GYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPV 187 + LP F + R+PLGV I WNYP +A+WK APALA G V KPS V Sbjct: 130 KAPVTLPMERFKSHVLRQPLGVVGLISPWNYPLLMATWKIAPALAAGCTAVLKPSELASV 189 Query: 188 SALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK 246 + L E+ +E G+PPG+ N++ G G G L HPDV K++FTGS TG K+M +A+ Sbjct: 190 TCLEFGEVCNEVGLPPGVLNILTGLGPDAGAPLVSHPDVDKIAFTGSSATGSKVMASAAQ 249 Query: 247 GIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTE 306 +KPVTLELGGKSP+++F D D++ V+ + F T GQ+C +R+ V + I +F + Sbjct: 250 LVKPVTLELGGKSPIVVFEDVDIDKVVEWTIFGCFWTNGQICSATSRLLVHESIAAEFVD 309 Query: 307 EVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPK 366 ++VK T+ IKI DP E R+GP+I++ ++++ F+ AK +GA +L GG Sbjct: 310 KLVKWTKNIKISDPFEEGCRLGPVISKGQYDKIMKFISTAKSEGATILYGGSR----PEH 365 Query: 367 LKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTR 426 LK GYY+ P ++T+ M KEE+FGPV+ + +F +E E + ANDT +GLAA VF+ Sbjct: 366 LKKGYYIEPTIVTDISTSMQIWKEEVFGPVLCVKTFSSEDEAIALANDTEYGLAAAVFSN 425 Query: 427 DIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 486 D++R R+ L+ G ++N V+ P+GG K+SGFGRE G I+ Y +K V + Sbjct: 426 DLERCERITKALEVGAVWVNCSQPCFVQAPWGGIKRSGFGRELGEWGIQNYLNIKQVTQD 485 Query: 487 MGDVE 491 + D Sbjct: 486 ISDEP 490 >4CAZ-A nrPDB Length = 490 Score = 608 bits (1568), Expect = e-174, Method: Composition-based stats. Identities = 255/484 (52%), Positives = 334/484 (69%), Gaps = 6/484 (1%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMER 73 Y GG VE A + T + PA G V+A + ++V AVQ+A K+W+ + M+R Sbjct: 10 YIGGRYVE-ASSGATFETINPANGEVLAKVQRASREDVERAVQSAVEGQKVWAAMTAMQR 68 Query: 74 CRILLEAARIIREREDEIATMECINNGKSIFEAR-LDIDISWQCLEYYAGLAASMAGEHI 132 RIL A I+RER DE+A +E ++ GK + E R +DI LEYYAGL ++ GE I Sbjct: 69 SRILRRAVDILRERNDELAALETLDTGKPLAETRSVDIVTGADVLEYYAGLVPAIEGEQI 128 Query: 133 QLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLL 192 L SF YTRREPLGV GIGAWNYP QIA WKSAPALA GNAM+FKPS TP++AL L Sbjct: 129 PLRETSFVYTRREPLGVVAGIGAWNYPVQIALWKSAPALAAGNAMIFKPSEVTPLTALKL 188 Query: 193 AEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMS-AKGIKP 250 AEIY+EAGVP G+FNV+ G G GQ+L +HP + K+SFTG TG K+M + + +K Sbjct: 189 AEIYTEAGVPDGVFNVLTGSGREVGQWLTEHPLIEKISFTGGTSTGKKVMASASSSSLKE 248 Query: 251 VTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVK 310 VT+ELGGKSPLIIF D D++ A A+MANF + GQVC NGTRVF+ + +F +V++ Sbjct: 249 VTMELGGKSPLIIFPDADLDRAADIAVMANFFSSGQVCTNGTRVFIHRSQQARFEAKVLE 308 Query: 311 QTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDG 370 + QRI++GDP E+T GPL++ PH+E VLG+++ K Q A++LCGG+ D G Sbjct: 309 RVQRIRLGDPQDENTNFGPLVSFPHMESVLGYIESGKAQKARLLCGGERVT--DGAFGKG 366 Query: 371 YYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQR 430 Y+ P V T+CRDDMT V+EEIFGPVMSIL +D E E + RANDT +GLAAGV T+D+ R Sbjct: 367 AYVAPTVFTDCRDDMTIVREEIFGPVMSILVYDDEDEAIRRANDTEYGLAAGVVTQDLAR 426 Query: 431 AHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDV 490 AHR + L+AG C+IN + SP E+P GGYK+SG GRENG T+ +Y+++K+V VE+GD Sbjct: 427 AHRAIHRLEAGICWINTWGESPAEMPVGGYKQSGVGRENGLTTLAHYTRIKSVQVELGDY 486 Query: 491 ESAF 494 S F Sbjct: 487 ASVF 490 >4O6R-A nrPDB Length = 496 Score = 605 bits (1560), Expect = e-173, Method: Composition-based stats. Identities = 197/497 (39%), Positives = 279/497 (56%), Gaps = 6/497 (1%) Query: 1 MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA 60 M+ Q + G V+ D GT P G VI + +V+LAV A Sbjct: 1 MAHHHHHHMQTQLFIDGRFVDAVD-RGTIDVLNPHDGSVITKIAAATAADVDLAVDAATR 59 Query: 61 AFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARL-DIDISWQCLEY 119 AF WS ER R+LL A I + +A +E ++ G I ++R D+ + C Y Sbjct: 60 AFPAWSAMPAAERGRLLLRLADAIEANTEALAQLESLDTGHPIRDSRALDVPRTAACFRY 119 Query: 120 YAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVF 179 + G+A + G I + G Y +R P+GV I WN+P SWK PALA GN +V Sbjct: 120 FGGMADKLQGSVIPVDTGFLNYVQRAPIGVVGQIVPWNFPLMFTSWKMGPALAAGNTVVL 179 Query: 180 KPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGM 238 KPS TP+S L + E+ +E G P G+ N+V G G GQ L +HP V K++FTGS TG Sbjct: 180 KPSEITPLSTLRIVELMAEVGFPAGVVNIVPGYGHTAGQRLAEHPGVGKIAFTGSTATGR 239 Query: 239 KIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQK 298 +I+E S +K V LELGGK I+F D +++ A+ GA A F QGQ C G+R+ + + Sbjct: 240 RIVEASQGNLKRVQLELGGKGANIVFDDANLDAAINGAAWAIFHNQGQACIAGSRLVLHE 299 Query: 299 EILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGD 358 I D F E V I+IG+PL +T MGPL ++ HL+RVL +V VA+EQG +VL GG Sbjct: 300 RIADAFLERFVALASSIRIGNPLDPNTEMGPLTSKQHLDRVLSYVDVAREQGGRVLTGGS 359 Query: 359 IYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFG 418 P+DP L +GYY+RP ++ +EE+FGP +++L F ++ E L AN T +G Sbjct: 360 --APQDPALANGYYVRPTIVEAKHATDRVAQEEVFGPFVTVLRFGSDDEALAIANATEYG 417 Query: 419 LAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYS 478 L +G++T D+ RAHR+ A + AG C+IN Y PFGG KSG+GRE G + Y+ Sbjct: 418 LGSGLWTNDLSRAHRMAARIDAGMCWINCYKRVNPGSPFGGVGKSGYGREMGFEAMHDYT 477 Query: 479 QLKTVCVEM-GDVESAF 494 + ++V V + G+V F Sbjct: 478 EARSVWVNVDGNVPPHF 494 >3R31-A nrPDB Length = 517 Score = 591 bits (1523), Expect = e-169, Method: Composition-based stats. Identities = 250/498 (50%), Positives = 331/498 (66%), Gaps = 9/498 (1%) Query: 1 MSTGTFVVSQPL--NYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNA 58 M+ T + +QP ++ G VE + ++ PATG +IA + V A+ +A Sbjct: 3 MTIATPLKAQPKASHFIDGDYVED-NTGTPFESIFPATGEMIAKLHAATPAIVERAIASA 61 Query: 59 KAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEAR-LDIDISWQCL 117 K A K W+ S M R RIL AA I+RER D ++T+E ++ GK I E D Sbjct: 62 KRAQKEWAAMSPMARGRILKRAADIMRERNDALSTLETLDTGKPIQETIVADPTSGADAF 121 Query: 118 EYYAGLAA-SMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNA 176 E++ G+A ++ G++I L GG F YT+R PLGVCVGIGAWNYP QIA WK+APAL GNA Sbjct: 122 EFFGGIAPSALNGDYIPL-GGDFAYTKRVPLGVCVGIGAWNYPQQIACWKAAPALVAGNA 180 Query: 177 MVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPT 236 MVFKPS TP+ AL +AEI EAG+P GLFNV+QG TG L HPDVAKVS TGSVPT Sbjct: 181 MVFKPSENTPLGALKIAEILIEAGLPKGLFNVIQGDRDTGPLLVNHPDVAKVSLTGSVPT 240 Query: 237 GMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFV 296 G K+ +A +K VT+ELGGKSP+I+F D D+ +AV GA++ NF + GQVC NGTRVFV Sbjct: 241 GRKVAAAAAGHLKHVTMELGGKSPMIVFDDADIESAVGGAMLGNFYSSGQVCSNGTRVFV 300 Query: 297 QKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCG 356 QK+ +F E + ++T+ + +GDPL T +GPL+++ E+VL +++ K +GA ++ G Sbjct: 301 QKKAKARFLENLKRRTEAMILGDPLDYATHLGPLVSKAQQEKVLSYIEKGKAEGATLITG 360 Query: 357 GDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTT 416 G I + +G Y++P V + DDMT +EEIFGPVM +L FD E EVL RAN T Sbjct: 361 GGIP---NNVAGEGAYVQPTVFADVTDDMTIAREEIFGPVMCVLDFDDEDEVLARANATE 417 Query: 417 FGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEY 476 FGLA GVFT D+ RAHRVV L+AGT +IN YN+ PVE+PFGG K+SGFGREN +E+ Sbjct: 418 FGLAGGVFTADLARAHRVVDGLEAGTLWINTYNLCPVEIPFGGSKQSGFGRENSAAALEH 477 Query: 477 YSQLKTVCVEMGDVESAF 494 YS+LKTV V G V++ + Sbjct: 478 YSELKTVYVSTGKVDAPY 495 >4MPY-A nrPDB Length = 520 Score = 587 bits (1515), Expect = e-168, Method: Composition-based stats. Identities = 182/478 (38%), Positives = 274/478 (57%), Gaps = 7/478 (1%) Query: 13 NYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFK--IWSQKSG 70 Y G VE A+ + T P VI T + +++ A+ A+ AF+ WSQ++ Sbjct: 35 QYIDGEWVESANKN-TRDIINPYNQEVIFTVSEGTKEDAERAILAARRAFESGEWSQETA 93 Query: 71 MERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGE 130 R + + A I+E + +A +E ++ GK++ E+ D+D Y+AGLA GE Sbjct: 94 ETRGKKVRAIADKIKEHREALARLETLDTGKTLEESYADMDDIHNVFMYFAGLADKDGGE 153 Query: 131 HIQLP-GGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSA 189 I P + +EP+GV I WNYP ASWK APALA G ++V KPS TP++ Sbjct: 154 MIDSPIPDTESKIVKEPVGVVTQITPWNYPLLQASWKIAPALATGCSLVMKPSEITPLTT 213 Query: 190 LLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGI 248 + + E+ E G P G N++ G G+ G + H +V VSFTG + TG IM+ +A + Sbjct: 214 IRVFELMEEVGFPKGTINLILGAGSEVGDVMSGHKEVDLVSFTGGIETGKHIMKNAANNV 273 Query: 249 KPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEV 308 + LELGGK+P IIF D D AV AL + GQVC G+R+ VQ I DKF + + Sbjct: 274 TNIALELGGKNPNIIFDDADFELAVDQALNGGYFHAGQVCSAGSRILVQNSIKDKFEQAL 333 Query: 309 VKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLK 368 + + ++IK+G+ DT MGP+I+ H ++ ++ VAK +GA + GG P+ LK Sbjct: 334 IDRVKKIKLGNGFDADTEMGPVISTEHRNKIESYMDVAKAEGATIAVGGKR--PDRDDLK 391 Query: 369 DGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDI 428 DG + P V+TNC M V+EE+FGPV+++ F+TE E ++ AND+ +GLA VF++DI Sbjct: 392 DGLFFEPTVITNCDTSMRIVQEEVFGPVVTVEGFETEQEAIQLANDSIYGLAGAVFSKDI 451 Query: 429 QRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 486 +A RV +L+ GT +IN+++ + P+GGYK+SG GRE G+ +E Y K + Sbjct: 452 GKAQRVANKLKLGTVWINDFHPYFAQAPWGGYKQSGIGRELGKEGLEEYLVSKHILTN 509 >4PZ2-A nrPDB Length = 534 Score = 585 bits (1509), Expect = e-167, Method: Composition-based stats. Identities = 200/484 (41%), Positives = 289/484 (59%), Gaps = 11/484 (2%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFK--IWSQKSGM 71 + G+ V+ A + T +P TG VIA+ + +++V+LAV+ A+AAF W + SG Sbjct: 54 FINGSFVD-AVSGRTFDTRDPRTGGVIASVAEADKEDVDLAVRAARAAFDHGEWPRMSGS 112 Query: 72 ERCRILLEAARIIREREDEIATMECINNGK-SIFEARLDIDISWQCLEYYAGLAASMAGE 130 ER RI+ A ++ E E+A +E ++ GK +D+ + L Y+AG A + GE Sbjct: 113 ERGRIMARLADLVEEHAGELAALESLDAGKHPAVTRAVDVGNAAGSLRYFAGAADKIHGE 172 Query: 131 HIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSAL 190 +++PG G+T REPLGV I WN+P + + K APALA G A+V KP+ TP+SAL Sbjct: 173 TLKMPGQFQGHTLREPLGVAGVIIPWNFPSTMFAVKVAPALAAGCALVVKPAEQTPLSAL 232 Query: 191 LLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK-GI 248 LA++ +AGVP G+ NVV G G G L H DV VSFTGS G IM+ SA+ + Sbjct: 233 YLAQLAKQAGVPDGVINVVPGFGPTAGAALASHMDVDMVSFTGSTEVGRLIMKASAESNL 292 Query: 249 KPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEV 308 KPV LELGGKSPLI+F D D++ AV+ A+ A+F +G+ C +RV+VQ+ + D+F E + Sbjct: 293 KPVYLELGGKSPLIVFDDADLDMAVELAVGASFFNKGEACVAASRVYVQERVYDRFEERL 352 Query: 309 VKQTQRIKIGDPL-LEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKL 367 ++ + +GDP GP +++ ERVL ++ K +GA +L GG PE Sbjct: 353 AERMRSWVVGDPFSDPRADQGPQVDKAQYERVLSYIDHGKREGATLLTGGRPCAPE---- 408 Query: 368 KDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRD 427 GYY+ P V TN ++DM KEEIFGPVM ++ F T E + RANDT +GL AGV TRD Sbjct: 409 GKGYYIEPTVFTNVKEDMIIAKEEIFGPVMCLMKFKTVEEAIARANDTRYGLGAGVVTRD 468 Query: 428 IQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 487 + A+RVV ++AG ++N Y + PFGG K SGFG++ G ++ Y +K+V + Sbjct: 469 LDVANRVVRSVRAGVVWVNCYFAMGSDCPFGGRKMSGFGKDEGMHALDKYLAVKSVVTPL 528 Query: 488 GDVE 491 Sbjct: 529 RASP 532 >3IWK-A nrPDB Length = 503 Score = 577 bits (1489), Expect = e-165, Method: Composition-based stats. Identities = 193/488 (39%), Positives = 278/488 (56%), Gaps = 15/488 (3%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAF-----KIWSQK 68 + G P + P+T +I + +++V+LAV AK A + WS Sbjct: 11 FIDGEWRVPI-LNKRIPNINPSTENIIGDIPAATKEDVDLAVDAAKRAISRKNGRDWSAA 69 Query: 69 SGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMA 128 SG R R L A I+E++DE+ +E I+ GK + EA D+D C EYYAGLA + Sbjct: 70 SGSLRARYLRAIAAKIKEKKDELGKLESIDCGKPLEEALADLDDVVACFEYYAGLAEELD 129 Query: 129 GE---HIQLPGGSF-GYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPF 184 + I LP +F Y +EP+GV I WNYPF +A+WK APALA G A + KPS Sbjct: 130 SKQKAPISLPMDTFKSYILKEPIGVVALITPWNYPFLMATWKIAPALAAGCAAILKPSEL 189 Query: 185 TPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEM 243 V+ L L EI E G+P G+ N+V G G G L HPDV K+SFTGS TG KIM Sbjct: 190 ASVTCLELGEICKEVGLPRGVLNIVTGLGHEAGASLASHPDVDKISFTGSSATGSKIMTT 249 Query: 244 SAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDK 303 +A+ +KPV+LELGGKSP+++F D D++ + + F T GQ+C +R+ V + I + Sbjct: 250 AAQLVKPVSLELGGKSPIVVFEDVDLDKVAEWTVFGCFFTNGQICSATSRLIVHESIAVE 309 Query: 304 FTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPE 363 F +++VK + IKI DPL E R+GP+++ ++VL + AK +GA +L GG Sbjct: 310 FVDKLVKWAENIKISDPLEEGCRLGPIVSEAQYKKVLNCISSAKSEGATILTGGRR---- 365 Query: 364 DPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGV 423 LK GY++ P ++T+ M +EE+FGPV+++ +F TE E + ANDT +GL + V Sbjct: 366 PEHLKKGYFVEPTIITDVTTSMQIWREEVFGPVLAVKTFSTEEEAINLANDTHYGLGSAV 425 Query: 424 FTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTV 483 + D++R R+ LQAG +IN S ++ P+GG K+SGFGRE G +E Y +K V Sbjct: 426 MSNDLERCERLSKALQAGIVWINCAQPSFIQAPWGGIKRSGFGRELGEWGLENYLSVKQV 485 Query: 484 CVEMGDVE 491 D Sbjct: 486 TRYTSDEP 493 >4PXL-B nrPDB Length = 517 Score = 577 bits (1487), Expect = e-165, Method: Composition-based stats. Identities = 188/483 (38%), Positives = 284/483 (58%), Gaps = 12/483 (2%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFK--IWSQKSGM 71 + G V+ A + T + +P TG VIA+ + +V+LAV+ A+ AF W + +G Sbjct: 40 FIDGKFVD-AVSGKTFETRDPRTGEVIASIAEGDKADVDLAVKAAREAFDNGPWPRMTGY 98 Query: 72 ERCRILLEAARIIREREDEIATMECINNGKSIFEARL-DIDISWQCLEYYAGLAASMAGE 130 ER RIL A +I E +E+A ++ ++ GK + DI + L YYAG A + G Sbjct: 99 ERGRILHRFADLIDEHVEELAALDTVDAGKLFAVGKARDIPGAAHLLRYYAGAADKVHGA 158 Query: 131 HIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSAL 190 +++ GYT +EP+GV I WNYP + +K PALA G A+V KP+ TP+SAL Sbjct: 159 TLKMAQRMHGYTLKEPVGVVGHIVPWNYPTTMFFFKVGPALAAGCAVVVKPAEQTPLSAL 218 Query: 191 LLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK-GI 248 A + EAGVP G+ NVV G G G + H DV KVSFTGS G +M +A+ + Sbjct: 219 FYAHLAREAGVPAGVLNVVPGFGPTAGAAVAAHMDVDKVSFTGSTEVGRLVMRAAAESNL 278 Query: 249 KPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEV 308 KPV+LELGGKSP+I+F D D++ AV A + +G++C GTR++VQ+ I D+F ++ Sbjct: 279 KPVSLELGGKSPVIVFDDADLDMAVNLVNFATYTNKGEICVAGTRIYVQEGIYDEFVKKA 338 Query: 309 VKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLK 368 + + +GDP GP +++ E+VL ++ + K +GA ++ GG P Sbjct: 339 AELASKSVVGDPFNPSVSQGPQVDKDQYEKVLRYIDIGKREGATLVTGGK------PCGD 392 Query: 369 DGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDI 428 GYY+ P + T+ +DDMT ++EIFGPVM+++ F T EV+++AN+T +GLAAG+ T++I Sbjct: 393 KGYYIEPTIFTDVKDDMTIAQDEIFGPVMALMKFKTVEEVIQKANNTRYGLAAGIVTKNI 452 Query: 429 QRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMG 488 A+ V ++AG +IN Y + PFGGYK SGFG++ G ++ Y Q KTV + Sbjct: 453 DVANTVSRSIRAGAIWINCYFAFDPDAPFGGYKMSGFGKDMGMDALDKYLQTKTVVTPLY 512 Query: 489 DVE 491 + Sbjct: 513 NTP 515 >4GO4-A nrPDB Length = 495 Score = 576 bits (1486), Expect = e-165, Method: Composition-based stats. Identities = 191/488 (39%), Positives = 279/488 (57%), Gaps = 7/488 (1%) Query: 10 QPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKS 69 Q Y G V+ A A GT P G +I + +V+LAV AK AF WS Sbjct: 2 QNQLYIDGRFVD-AVAGGTIDVVSPHDGSLITRIAAAEAADVDLAVAAAKRAFPAWSALG 60 Query: 70 GMERCRILLEAARIIREREDEIATMECINNGKSIFEARL-DIDISWQCLEYYAGLAASMA 128 ER R+LL+ A I E +E+A +E +N G I ++R D+ + C Y+ G+A + Sbjct: 61 AAERGRLLLKLADRIEECSEELAQLESLNTGHPIRDSRGLDVPRTAACFRYFGGMADKIE 120 Query: 129 GEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVS 188 G I + G Y +R+P+GV I WN+P SWK PALA GN +V KPS TP+S Sbjct: 121 GSVIPVDAGFLNYVQRKPIGVVAQIVPWNFPLMFTSWKMGPALAAGNTIVIKPSEITPLS 180 Query: 189 ALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKG 247 L + E+ +E G P G+ NVV G G GQ L +H DV K++FTGS TG +I+E S Sbjct: 181 TLRIVELMTEVGFPKGVVNVVPGYGHTAGQALAEHLDVGKIAFTGSTATGRRIVEASKSN 240 Query: 248 IKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEE 307 +K + LELGGK I+F D ++ AV GA A F QGQ C G+R+ + K+I D+F E Sbjct: 241 LKRIQLELGGKGANIVFEDANIEAAVNGAAWAIFHNQGQACIAGSRLILHKDIADQFLER 300 Query: 308 VVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKL 367 + + I++GDP+ +T MGPL + +RVL ++ +A EQG KVL GG P+D L Sbjct: 301 FIALAKSIRLGDPMDPETEMGPLTSALRRDRVLSYIDIAIEQGGKVLAGGK--APDDKAL 358 Query: 368 KDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRD 427 +G+Y+ P V+ D +EE+FGP ++++ F ++ E L AN+T +GL +G++T++ Sbjct: 359 ANGFYVEPTVVEAKPQD-RVCQEEVFGPFVTVVRFSSDEEALAIANNTEYGLGSGLWTQN 417 Query: 428 IQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 487 + RAH++ + AG C+IN Y PFGG +SG+GRE G I Y++ ++V V + Sbjct: 418 LARAHKMAHAIHAGMCWINCYKRVSPGSPFGGVGQSGYGREMGFEAIHDYTEARSVWVNV 477 Query: 488 -GDVESAF 494 + F Sbjct: 478 DAKIAPHF 485 >3JZ4-A nrPDB Length = 481 Score = 569 bits (1467), Expect = e-163, Method: Composition-based stats. Identities = 169/475 (35%), Positives = 251/475 (52%), Gaps = 9/475 (1%) Query: 15 RGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERC 74 G ++ + PA G + + G E A+ A A W + ER Sbjct: 14 INGEWLDANNGEA-IDVTNPANGDKLGSVPKMGADETRAAIDAANRALPAWRALTAKERA 72 Query: 75 RILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQL 134 IL ++ E +D++A + + GK + EA+ +I + +E++A + G+ I Sbjct: 73 TILRNWFNLMMEHQDDLARLMTLEQGKPLAEAKGEISYAASFIEWFAEEGKRIYGDTIPG 132 Query: 135 PG-GSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLA 193 ++P+GV I WN+P + + K+ PALA G MV KP+ TP SAL LA Sbjct: 133 HQADKRLIVIKQPIGVTAAITPWNFPAAMITRKAGPALAAGCTMVLKPASQTPFSALALA 192 Query: 194 EIYSEAGVPPGLFNVVQGG-AATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVT 252 E+ AGVP G+FNVV G A G L +P V K+SFTGS G ++ME AK IK V+ Sbjct: 193 ELAIRAGVPAGVFNVVTGSAGAVGNELTSNPLVRKLSFTGSTEIGRQLMEQCAKDIKKVS 252 Query: 253 LELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQT 312 LELGG +P I+F D D++ AV+GAL + F GQ C R++VQ + D+F E++ + Sbjct: 253 LELGGNAPFIVFDDADLDKAVEGALASKFRNAGQTCVCANRLYVQDGVYDRFAEKLQQAM 312 Query: 313 QRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYY 372 ++ IGD L +GPLI+ + +V + A E+GA+V+CGG + G + Sbjct: 313 SKLHIGDGLDNGVTIGPLIDEKAVAKVEEHIADALEKGARVVCGGK------AHERGGNF 366 Query: 373 MRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAH 432 +P +L + + KEE FGP+ + F EA+V+ +ANDT FGLAA + RD+ R Sbjct: 367 FQPTILVDVPANAKVSKEETFGPLAPLFRFKDEADVIAQANDTEFGLAAYFYARDLSRVF 426 Query: 433 RVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 487 RV L+ G IN +S PFGG K SG GRE + IE Y ++K +C+ + Sbjct: 427 RVGEALEYGIVGINTGIISNEVAPFGGIKASGLGREGSKYGIEDYLEIKYMCIGL 481 >3IWJ-A nrPDB Length = 503 Score = 569 bits (1467), Expect = e-162, Method: Composition-based stats. Identities = 187/488 (38%), Positives = 274/488 (56%), Gaps = 15/488 (3%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAF-----KIWSQK 68 + G P + PAT +I + +++V++AV AK A W+ Sbjct: 11 FINGDWKAPV-LNKRIPVINPATQNIIGDIPAATKEDVDVAVAAAKTALTRNKGADWATA 69 Query: 69 SGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMA 128 SG R R L A + E++ E+A +E I+ GK + EA DID C EYYA LA + Sbjct: 70 SGAVRARYLRAIAAKVTEKKPELAKLESIDCGKPLDEAAWDIDDVAGCFEYYADLAEKLD 129 Query: 129 GE---HIQLPGGSF-GYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPF 184 + LP +F + REP+GV I WNYP +A+WK APALA G A + KPS Sbjct: 130 ARQKAPVSLPMDTFKSHVLREPIGVVGLITPWNYPMLMATWKVAPALAAGCAAILKPSEL 189 Query: 185 TPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEM 243 ++ L L EI E G+PPG+ N++ G G G L HPDV KV+FTGS TG KIM Sbjct: 190 ASLTCLELGEICKEVGLPPGVLNILTGLGPEAGAPLATHPDVDKVAFTGSSATGSKIMTA 249 Query: 244 SAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDK 303 +A+ +KPV+LELGGKSPL++F D D++ A + A+ F T GQ+C +R+ + + I + Sbjct: 250 AAQLVKPVSLELGGKSPLVVFEDVDLDKAAEWAIFGCFWTNGQICSATSRLILHESIATE 309 Query: 304 FTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPE 363 F +VK + IKI DPL E R+GP+++ E++L FV AK +GA +L GG Sbjct: 310 FLNRIVKWIKNIKISDPLEEGCRLGPVVSEGQYEKILKFVSNAKSEGATILTGGSR---- 365 Query: 364 DPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGV 423 LK G+++ P ++T+ +M +EE+FGPV+ + +F TE E ++ ANDT +GL A V Sbjct: 366 PEHLKKGFFIEPTIITDVTTNMQIWREEVFGPVLCVKTFSTEEEAIDLANDTVYGLGAAV 425 Query: 424 FTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTV 483 + D++R RV +AG ++N + P+GG K+SGFGRE G ++ Y +K V Sbjct: 426 ISNDLERCERVTKAFKAGIVWVNCSQPCFTQAPWGGVKRSGFGRELGEWGLDNYLSVKQV 485 Query: 484 CVEMGDVE 491 + + Sbjct: 486 TQYISEEP 493 >2D4E-A nrPDB Length = 515 Score = 565 bits (1456), Expect = e-161, Method: Composition-based stats. Identities = 184/481 (38%), Positives = 281/481 (58%), Gaps = 6/481 (1%) Query: 12 LNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGM 71 L++ G V P+++ T + +PAT V+ GE+EV+ A + A AF+ WS+ Sbjct: 28 LHFIAGEFV-PSESGETFPSLDPATNEVLGVAARGGEREVDRAAKAAHEAFQRWSRTKAK 86 Query: 72 ERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLA-ASMAGE 130 ER R LL A +I + DE+A MEC++ G+ + R + + + +YA A +M Sbjct: 87 ERKRYLLRIAELIEKHADELAVMECLDAGQVLRIVRAQVARAAENFAFYAEYAEHAMEDR 146 Query: 131 HIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSAL 190 + YT R P G I WN P +++W+ APALA GN +V KP+ ++P +A Sbjct: 147 TFPVDRDWLYYTVRVPAGPVGIITPWNAPLMLSTWRIAPALAFGNTVVLKPAEWSPFTAT 206 Query: 191 LLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIK 249 LAEI EA +PPG+FN+VQG G G L HP V ++ TG TG +M +A +K Sbjct: 207 KLAEILKEADLPPGVFNLVQGFGEEAGAALVAHPLVPLLTLTGETETGKIVMRNAADHLK 266 Query: 250 PVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVV 309 ++ ELGGKSP ++F+D D+ A+ + F G+ C +R+ V+++I + F +VV Sbjct: 267 RLSPELGGKSPALVFADADLERALDAVVFQIFSFNGERCTASSRLLVEEKIFEDFVGKVV 326 Query: 310 KQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVP--EDPKL 367 ++ + I++G PL +T +GPLI+ HL+RVLG+V+ K +GA++L GG+ L Sbjct: 327 ERARAIRVGHPLDPETEVGPLIHPEHLQRVLGYVEAGKREGARLLVGGERAKTSFRGEDL 386 Query: 368 KDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRD 427 G Y+ P V + M +EEIFGPV+ + F E E L +ANDT +GLAA VFTRD Sbjct: 387 SRGNYLLPTVFVG-ENHMKIAQEEIFGPVLVAIPFKDEEEALRKANDTKYGLAAYVFTRD 445 Query: 428 IQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 487 ++RAHR+ EL+AG ++N++NV + PFGG K SG RE G +++Y+ LKT+ + + Sbjct: 446 LERAHRLALELEAGMVYLNSHNVRHLPTPFGGVKGSGDRREGGTYALDFYTDLKTIALPL 505 Query: 488 G 488 Sbjct: 506 R 506 >3RHO-A nrPDB Length = 517 Score = 564 bits (1453), Expect = e-161, Method: Composition-based stats. Identities = 191/485 (39%), Positives = 290/485 (59%), Gaps = 18/485 (3%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFK--IWSQKSGM 71 + GG V+ A+ S T P G VI + + +V+ AV AK AF+ +W + + Sbjct: 40 FIGGEFVD-AEGSKTYNTINPTDGSVICQVSLAQVSDVDKAVAAAKEAFENGLWGKINAR 98 Query: 72 ERCRILLEAARIIREREDEIATMECINNGKSIFEA-RLDIDISWQCLEYYAGLAASMAGE 130 +R R+L A ++ + ++E+AT+E ++ G A + + +S Q Y+AG + G Sbjct: 99 DRGRLLYRLADVMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGA 158 Query: 131 HIQL----PGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTP 186 I + P + T++EP+GVC + WNYP + SWK+A LA GN +V KP+ TP Sbjct: 159 TIPINQARPNRNLTLTKKEPVGVCGIVIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTP 218 Query: 187 VSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSA 245 ++AL AE+ +AG+P G+ N++ G G+ GQ L HPDV K+ FTGS G IM+ A Sbjct: 219 LTALKFAELTLKAGIPKGVVNILPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCA 278 Query: 246 -KGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKF 304 +K V+L+LGGKSPLIIF+DCD+N AV+ + + F +G+ C R+FV++ I ++F Sbjct: 279 LSNVKKVSLQLGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEESIHNQF 338 Query: 305 TEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPED 364 ++VV++ +++KIG+PL DT GP + HL +++ + + ++GA ++CGG+ Sbjct: 339 VQKVVEEVEKMKIGNPLERDTNHGPQNHEAHLRKLVEYCQRGVKEGATLVCGGNQVP--- 395 Query: 365 PKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSF--DTEAEVLERANDTTFGLAAG 422 + G++ +P V T+ D M KEE FGP+M I F VL RAN T FGLA+G Sbjct: 396 ---RPGFFFQPTVFTDVEDHMYIAKEESFGPIMIISRFADGDVDAVLSRANATEFGLASG 452 Query: 423 VFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKT 482 VFTRDI +A V +LQAGT FIN YN + V PFGG+K+SGFG++ G + Y ++KT Sbjct: 453 VFTRDINKALYVSDKLQAGTVFINTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRIKT 512 Query: 483 VCVEM 487 V E Sbjct: 513 VTFEY 517 >4I8Q-A nrPDB Length = 514 Score = 560 bits (1443), Expect = e-160, Method: Composition-based stats. Identities = 190/489 (38%), Positives = 278/489 (56%), Gaps = 13/489 (2%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAA--FKIWSQKSGM 71 Y GG EP + PAT +I + ++V++AV+ A+ A W +G Sbjct: 27 YIGGEWREPVKKNR-IPIINPATEEIIGDIPAATAEDVDIAVEAARKAIARDDWGSTTGA 85 Query: 72 ERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEH 131 +R + L A + E++ +AT+E +++GK+++E+ D+D C EYYAGLA ++ Sbjct: 86 QRAKYLRAIAAKVLEKKSVLATLESLDSGKTLYESAADMDDVAGCFEYYAGLAEALDSRR 145 Query: 132 IQ----LPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPV 187 + Y REPLGV I WNYP +A WK APALA G A + KPS + Sbjct: 146 MTPVNLNSDSYKSYVLREPLGVVGLITPWNYPLLMAIWKVAPALAAGCAAILKPSELASI 205 Query: 188 SALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK 246 + L L EI E G+P G N++ G G G L HP V K+SFTGS PTG KIM +A+ Sbjct: 206 TCLELGEICREIGLPSGALNILTGLGPEAGGPLASHPHVDKISFTGSGPTGSKIMTAAAQ 265 Query: 247 GIKPVTLELGGKSPLIIFSDCD-MNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFT 305 +KPV+L LGGKSP+++F D D ++ A + L F GQVC +R+ VQ+ I F Sbjct: 266 LVKPVSLALGGKSPIVVFDDIDNLDIAAEWTLFGIFANTGQVCSATSRLIVQENIASAFM 325 Query: 306 EEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDP 365 + ++K T+ IKI DPL ED ++GP+++ E+VL F+ AK +GA +LCGG+ Sbjct: 326 DRLLKWTKNIKISDPLEEDCKLGPVVSAGQYEKVLKFISNAKSEGATILCGGER----PQ 381 Query: 366 KLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFT 425 LK GYY++P ++T+ M KEE+FGPV+ + +F TE + +E ANDT +GL A V + Sbjct: 382 HLKKGYYVQPTIITDVNTSMEIWKEEVFGPVLCVKTFKTEEQAIELANDTKYGLGAAVMS 441 Query: 426 RDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCV 485 +D++R R Q G +IN + ELP+GG K+SGFGR+ G+ +E + +K V Sbjct: 442 KDVKRCERFTKAFQTGIIWINCSQPTFNELPWGGKKRSGFGRDLGKWGLENFLNIKQVTE 501 Query: 486 EMGDVESAF 494 AF Sbjct: 502 YTSAEPLAF 510 >4I8P-A nrPDB Length = 520 Score = 559 bits (1442), Expect = e-160, Method: Composition-based stats. Identities = 187/488 (38%), Positives = 266/488 (54%), Gaps = 15/488 (3%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI-----WSQK 68 + G PA P T I ++V+ AV A+AA K W++ Sbjct: 28 FVDGEWRPPAQGRR-LPVVNPTTEAHIGEIPAGTAEDVDAAVAAARAALKRNRGRDWARA 86 Query: 69 SGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMA 128 G R + L A + ER+ E+A +E ++ GK EA D+D C EY+A A ++ Sbjct: 87 PGAVRAKYLRAIAAKVIERKPELAKLEALDCGKPYDEAAWDMDDVAGCFEYFADQAEALD 146 Query: 129 GE---HIQLPGGSFG-YTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPF 184 + LP +F + RREP+GV I WNYP +A+WK APALA G V KPS Sbjct: 147 KRQNSPVSLPMETFKCHLRREPIGVVGLITPWNYPLLMATWKIAPALAAGCTAVLKPSEL 206 Query: 185 TPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEM 243 V+ L LA+I E G+P G+ N+V G G G L HPDV KV+FTGS TG KIM Sbjct: 207 ASVTCLELADICKEVGLPSGVLNIVTGLGPDAGAPLSAHPDVDKVAFTGSFETGKKIMAS 266 Query: 244 SAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDK 303 +A +KPVTLELGGKSP+++F D D++ AV+ L F T GQ+C +R+ + +I K Sbjct: 267 AAPMVKPVTLELGGKSPIVVFDDVDIDKAVEWTLFGCFWTNGQICSATSRLLIHTKIAKK 326 Query: 304 FTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPE 363 F E +V + IK+ DPL E R+GP+++ E++ F+ AK QGA +L GG Sbjct: 327 FNERMVAWAKNIKVSDPLEEGCRLGPVVSEGQYEKIKKFISNAKSQGATILTGG----VR 382 Query: 364 DPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGV 423 L+ G+++ P ++T+ M +EE+FGPV+ + F TE E +E ANDT +GLA V Sbjct: 383 PAHLEKGFFIEPTIITDITTSMEIWREEVFGPVLCVKEFSTEDEAIELANDTQYGLAGAV 442 Query: 424 FTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTV 483 + D +R R+ E+ AG ++N + P+GG K+SGFGRE G I+ Y +K V Sbjct: 443 ISGDRERCQRLSEEIDAGCIWVNCSQPCFCQAPWGGNKRSGFGRELGEGGIDNYLSVKQV 502 Query: 484 CVEMGDVE 491 + D Sbjct: 503 TEYISDEP 510 >5KLK-A nrPDB Length = 520 Score = 551 bits (1421), Expect = e-157, Method: Composition-based stats. Identities = 183/487 (37%), Positives = 284/487 (58%), Gaps = 12/487 (2%) Query: 9 SQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFK-IWSQ 67 SQ LNY G V A + P G++I+ + K+VN AV A+ A K W + Sbjct: 38 SQLLNYIDGNFVTSASSFAN---INPVNGKLISDVFEADAKQVNEAVVAAQNALKGPWGK 94 Query: 68 KSGMERCRILLEAARIIREREDEIATMECINNGKSIFEAR-LDIDISWQCLEYYAGLAAS 126 S +R ++ + A I+ R +E E + G+ + +AR LDI + +A LA + Sbjct: 95 LSVQDRAALIHKIADGIQARFEEFVAAEVADTGRPVHQARTLDIPRAIANFRTFADLAKT 154 Query: 127 MAGEHIQLP----GGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPS 182 + ++ G+ YT R+PLGV I W+ P + +WK APALACGN +V KPS Sbjct: 155 SHTDLFEMSTSDGSGALNYTVRKPLGVIGVISPWDLPLLLFTWKVAPALACGNTVVAKPS 214 Query: 183 PFTPVSALLLAEIYSEAGVPPGLFNVVQG--GAATGQFLCQHPDVAKVSFTGSVPTGMKI 240 +P SA LLAE+ +AGVPPG+FN++ G + G+FL QHP ++ ++FTG TG I Sbjct: 215 EESPSSATLLAEVMHDAGVPPGVFNLIHGFGKDSAGEFLTQHPGISALTFTGESKTGSTI 274 Query: 241 MEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEI 300 M+ A G+K V+ ELGGK+ ++F+D D++ A++G L ++F GQVC RV+V + I Sbjct: 275 MKAVADGVKEVSFELGGKNAAVVFADADLDAAIEGVLRSSFTNSGQVCLCSERVYVHRSI 334 Query: 301 LDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY 360 D+F + + +R+ +G P + MGPLI+ H ++VL + ++A ++GA V+ GG + Sbjct: 335 FDEFVSGLKVEAERLVVGYPDQDGVNMGPLISHGHRDKVLSYYRLAVDEGATVVTGGGVP 394 Query: 361 VPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA 420 D + G Y++P + T D CV EEIFGPV I FD E EV+ R ND+ +GLA Sbjct: 395 KFNDER-DQGAYVQPTIWTGLSDKARCVTEEIFGPVCHISPFDDEDEVINRVNDSNYGLA 453 Query: 421 AGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQL 480 ++T ++ RAHRV ++ G ++N + + + PFGG K SG GRE GR ++++YS + Sbjct: 454 CAIWTTNLSRAHRVSRQIHVGLVWVNTWYLRDLRTPFGGVKLSGLGREGGRFSMDFYSDI 513 Query: 481 KTVCVEM 487 +C+++ Sbjct: 514 ANICIKI 520 >4QYJ-A nrPDB Length = 516 Score = 549 bits (1415), Expect = e-157, Method: Composition-based stats. Identities = 183/484 (37%), Positives = 274/484 (56%), Gaps = 17/484 (3%) Query: 13 NYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFK--IWSQKSG 70 GG V A + T + PATG ++ ++VN AV++A A + W + Sbjct: 37 MLIGGQWV-SAQSGKTLNVYNPATGDILTEVPDGDVEDVNAAVESAAATLRSDTWRRMPP 95 Query: 71 MERCRILLEAARIIREREDEIATMECINNGKSIFEARL-DIDISWQCLEYYAGLAASMAG 129 R RILL A ++ DE+A +E +NNGK + ++L ++ S Q L Y AG A + G Sbjct: 96 SARERILLRLADLLEVHGDELARLETLNNGKLLIYSKLMEVGASAQWLRYMAGWATKLTG 155 Query: 130 EHI----QLPGG--SFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSP 183 + LP S T+R P+GV I WN+P +A WK APALACGN +V KP+ Sbjct: 156 STLDLSLPLPPEVRSRASTQRVPVGVVAAIIPWNFPLLMAVWKIAPALACGNTVVLKPAE 215 Query: 184 FTPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIME 242 TP++AL LAE+ EAG+P G NVV G G G L +HP VAKV+FTGS G I Sbjct: 216 ETPLTALRLAELAMEAGLPAGALNVVTGRGETAGDALVRHPKVAKVAFTGSTEVGRIIGS 275 Query: 243 MSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILD 302 + +K V+LELGGKSP+I+ +DCD A +GA A F GQVC G+R++V + I + Sbjct: 276 ACGRSLKAVSLELGGKSPVIVLADCDPQEAAEGAAAAIFFNHGQVCTAGSRLYVHESIYE 335 Query: 303 KFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVP 362 + + + I +G L + MGP++++ H E VL ++ E GA ++CGG Sbjct: 336 DVIQRLAVIGESIVVGSGLEQGVHMGPMVSKKHHENVLRHIRNGIEDGADLICGGT---- 391 Query: 363 EDPKLKDGYYMRPCVLTNC-RDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAA 421 + G++++P + N + D+ + +E+FGPV+ F AEV+ AN + +GL A Sbjct: 392 -EAPCAQGFFVKPTIFANREKKDIRLLSQEVFGPVLVATPFSDIAEVVNEANRSVYGLGA 450 Query: 422 GVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLK 481 ++T D+ A R+ EL+AGT ++N +N+ LPFGG+K SG GRE+G IE+Y+ + Sbjct: 451 SIWTNDLSAALRINDELEAGTVWVNTHNMVDPNLPFGGFKDSGVGREHGAAAIEHYTTTR 510 Query: 482 TVCV 485 ++ + Sbjct: 511 SLVI 514 >4O5H-A nrPDB Length = 511 Score = 542 bits (1398), Expect = e-154, Method: Composition-based stats. Identities = 175/497 (35%), Positives = 264/497 (53%), Gaps = 16/497 (3%) Query: 1 MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA 60 + +++P GA A + PA G VIA + E++V AV A+ Sbjct: 20 LDATRAFLAKPKQMLIGAEWSDAASGRQLDVVNPADGTVIARVPEADERDVQQAVAAARR 79 Query: 61 AFKI--WSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARL-DIDISWQCL 117 AF W +R R++L A +I E+A +E ++NGK + A+ D+ ++ QC Sbjct: 80 AFDAGPWRTAKTTDRERLMLVLADLIEANARELAEIESLDNGKPVMVAQGLDVAMAAQCF 139 Query: 118 EYYAGLAASMAGEHIQL------PGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPAL 171 Y AG A + G I F YTR+EP+GV I WN+P +A+WK APAL Sbjct: 140 RYMAGWATKIEGSVIDAGMPYLPDSEIFAYTRKEPVGVVGAIIPWNFPLLMAAWKIAPAL 199 Query: 172 ACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSF 230 A G +V KP+ TP+SAL L E+ AG P G+ N+V G G G L + P + K++F Sbjct: 200 ATGCTVVLKPAEDTPLSALRLGELIQAAGFPDGVVNIVTGYGHTAGAALSRDPRIDKIAF 259 Query: 231 TGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCN 290 TGS TG I + + ++LELGGKSP+I+ D D++ A +G A F QGQVC Sbjct: 260 TGSTQTGKTIGHAALDNMTRMSLELGGKSPVIVLPDVDLDKAAQGVANAIFFNQGQVCTA 319 Query: 291 GTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQG 350 G+R ++ ++ D E V K +KIG + T++GPL++ ERV G++ +G Sbjct: 320 GSRAYIHSKVFDGVIERVAKIAASLKIGPGMDPATQIGPLVSAKQRERVCGYIDSGFGEG 379 Query: 351 AKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLE 410 A G+++ P VL + M V+EEIFGPV+ + FD ++ Sbjct: 380 A------RAAAGGRAIDGPGFFVEPTVLVDTTQAMRVVREEIFGPVLVAMPFDDVDTAVQ 433 Query: 411 RANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENG 470 ANDT +GL A +++ D+ H++V + AGT ++N +++ LPFGG K+SGFGRE G Sbjct: 434 LANDTPYGLGASIWSNDLSAIHKLVPRIAAGTVWVNCHSLLDNALPFGGMKQSGFGRELG 493 Query: 471 RVTIEYYSQLKTVCVEM 487 R I+ Y++ K+V + Sbjct: 494 RAVIDQYTESKSVMMNY 510 >6B4R-B nrPDB Length = 497 Score = 542 bits (1397), Expect = e-154, Method: Composition-based stats. Identities = 158/480 (32%), Positives = 261/480 (54%), Gaps = 11/480 (2%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFK--IWSQKSGM 71 + G A + T P GR +A + AV+ A+ AF WS+ + Sbjct: 23 FVNGEY-SNAASGETFDCLSPVDGRFLAKVASCDLADAEQAVKVARNAFDSGAWSRLAPA 81 Query: 72 ERCRILLEAARIIREREDEIATMECINNGKSIFEAR-LDIDISWQCLEYYAGLAASMAGE 130 +R + ++ A ++ E +E+A +E ++ GK I ++ +D+ + L + A + E Sbjct: 82 KRKQTMIRFADLLLENAEELALLETLDMGKPISDSLHIDVASAANSLRWSAEAIDKIYDE 141 Query: 131 HIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSAL 190 P G REP+GV I WN+P ++ WK PALA GN+++ KPS +P++A+ Sbjct: 142 VAATPHAELGLVTREPVGVVAAIVPWNFPLLMSCWKLGPALATGNSVILKPSEKSPLTAI 201 Query: 191 LLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK-GI 248 +A++ EAG+P G+FNV+ G G G+ L H DV + FTGS ++M + + + Sbjct: 202 RIAQLAVEAGIPKGVFNVLPGYGHTVGKALALHMDVDTLVFTGSTKIAKQLMVYAGESNM 261 Query: 249 KPVTLELGGKSPLIIFSDC-DMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEE 307 K V LE GGKSP I+F+D D+ A + A A QG+VC G+R+ V++ I DKF Sbjct: 262 KRVWLEAGGKSPNIVFADAPDLKAAAEAAAGAIAFNQGEVCTAGSRLLVERSIKDKFLPL 321 Query: 308 VVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKL 367 V++ + K G+PL +T +G L++ + VL +++ GAK++ GG + E Sbjct: 322 VIEALKGWKPGNPLDPETNVGALVDTQQMNTVLSYIEAGHNDGAKLVAGGKRTLEE---- 377 Query: 368 KDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRD 427 G Y+ P + + M +EEIFGPV+S++ F+ E + ANDT +GLAA V+T + Sbjct: 378 TGGTYVEPTIFDGVTNAMKIAREEIFGPVLSVIEFEDAEEAVRIANDTPYGLAAAVWTSN 437 Query: 428 IQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 487 + +AH L+AG+ ++N Y+ + PFGG+K+SG GR+ + Y++LK +++ Sbjct: 438 LSKAHLTAKALRAGSVWVNQYDGGDMTAPFGGFKQSGNGRDKSLHAFDKYTELKATWIKL 497 >5IUV-A nrPDB Length = 497 Score = 541 bits (1395), Expect = e-154, Method: Composition-based stats. Identities = 162/489 (33%), Positives = 265/489 (54%), Gaps = 14/489 (2%) Query: 9 SQPLNYRGGARVE----PADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFK- 63 +Q L G A ++ A + T P GR++A + AV++A++AF Sbjct: 13 AQNLKIEGRAFIQGEYTAAASGETFDCISPVDGRLLAKVASCDAADAQRAVESARSAFDS 72 Query: 64 -IWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARL-DIDISWQCLEYYA 121 WS+ + +R ++ A ++ + +E+A +E ++ GK I ++ DI + L + Sbjct: 73 GAWSRLAPAKRKATMIRFAGLLEQNAEELALLETLDMGKPISDSLGVDIPGGARALSWSG 132 Query: 122 GLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKP 181 + E P G REP+GV I WN+P +A WK PAL+ GN++V KP Sbjct: 133 EAIDKLYDEVAATPHDQLGLVTREPVGVVAAIVPWNFPLMMACWKLGPALSTGNSVVLKP 192 Query: 182 SPFTPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKI 240 S +P++A+ +A++ EAG+P G+ NV+ G G G+ L H DV V FTGS ++ Sbjct: 193 SEKSPLTAIRIAQLAIEAGIPAGVLNVLPGYGHTVGKALALHMDVDTVVFTGSTKIAKQL 252 Query: 241 MEMSAK-GIKPVTLELGGKSPLIIFSDC-DMNNAVKGALMANFLTQGQVCCNGTRVFVQK 298 M + + +K V LE GGKSP I+F+D D+ A A A QG+VC G+R+ V++ Sbjct: 253 MIYAGESNMKRVWLEAGGKSPNIVFADAPDLQAAADSAASAIAFNQGEVCTAGSRLLVER 312 Query: 299 EILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGD 358 I D+F V++ K G+PL T +G L++ + VL ++ GA+++ GG Sbjct: 313 SIKDRFLPMVIEALGTWKPGNPLDPATNVGALVDTQQMNTVLSYIAAGHTDGARLVAGGK 372 Query: 359 IYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFG 418 + E G Y+ P + + M +EEIFGPV+S+L+FDT E ++ ANDT +G Sbjct: 373 QILQE----TGGTYVEPTIFDGVNNAMRIAQEEIFGPVLSVLTFDTAEEAIQIANDTPYG 428 Query: 419 LAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYS 478 LAA V+T ++ +AH L+AG+ ++N Y+ + PFGG+K+SG GR+ + Y+ Sbjct: 429 LAAAVWTANLSKAHLTARALRAGSVWVNQYDGGDMTAPFGGFKQSGNGRDKSLHAFDKYT 488 Query: 479 QLKTVCVEM 487 +LK+ +++ Sbjct: 489 ELKSTWIKL 497 >5J77-A nrPDB Length = 508 Score = 537 bits (1385), Expect = e-153, Method: Composition-based stats. Identities = 149/495 (30%), Positives = 251/495 (50%), Gaps = 14/495 (2%) Query: 1 MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA 60 M T ++ Q +N + + T + P TG+VI + +V+ A+ A+ Sbjct: 1 MDTKLYIDGQWVN---------SSSGKTVDKYSPVTGQVIGRMEAATRDDVDRAIDAAED 51 Query: 61 AFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYY 120 AF W+ +ER +I+ A +I + E+ + NGK + EA+ ++D ++YY Sbjct: 52 AFWAWNDLGSVERSKIIYRAKELIEKNRAELENIIMEENGKPVKEAKEEVDGVIDQIQYY 111 Query: 121 AGLAASMAGEHIQ-LPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVF 179 A A + GE ++ + + P G+ V + WN+P + + K APAL GN +V Sbjct: 112 AEWARKLNGEVVEGTSSHRKIFQYKVPYGIVVALTPWNFPAGMVARKLAPALLTGNTVVL 171 Query: 180 KPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGM 238 KPS TP SA + + EAGVP G+ N + G G+ G ++ +H V ++ TGS TG Sbjct: 172 KPSSDTPGSAEWIVRKFVEAGVPKGVLNFITGRGSEIGDYIVEHKKVNLITMTGSTATGQ 231 Query: 239 KIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQK 298 +IM+ ++ + + LELGGK+P +++ D DM+NA+K L A + GQ C R++V + Sbjct: 232 RIMQKASANMAKLILELGGKAPFMVWKDADMDNALKTLLWAKYWNAGQSCIAAERLYVHE 291 Query: 299 EILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGD 358 +I D F V+ ++++ +GDP ++ MGPLIN+ L+ V+ AKE GAK+L GG Sbjct: 292 DIYDTFMSRFVELSRKLALGDP--KNADMGPLINKGALQATSEIVEEAKESGAKILFGGS 349 Query: 359 IYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFG 418 P ++GY+ P ++ N +EEIF PV+ + E+ + AND +G Sbjct: 350 QPSLSGP-YRNGYFFLPTIIGNADQKSKIFQEEIFAPVIGARKISSVEEMYDLANDNKYG 408 Query: 419 LAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYS 478 LA+ +FT+D ++ G ++N + G++ +G E + I Y Sbjct: 409 LASYLFTKDPNIIFEASERIRFGELYVNMPGPEASQGYHTGFRMTGQAGEGSKYGISEYL 468 Query: 479 QLKTVCVEMGDVESA 493 +LK + V+ Sbjct: 469 KLKNIYVDYSGKPLH 483 >4V6H-A nrPDB Length = 484 Score = 536 bits (1382), Expect = e-153, Method: Composition-based stats. Identities = 169/474 (35%), Positives = 253/474 (53%), Gaps = 9/474 (1%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMER 73 Y GG + AD+ T + F+PATG + T G E A++ A+AA+ W K+ ER Sbjct: 16 YIGGEW-QAADSDATFEVFDPATGESLGTVPKMGAAETARAIEAAQAAWAGWRMKTAKER 74 Query: 74 CRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQ 133 IL ++ D++A + GK + EA+ +I + +E++A +AG+ + Sbjct: 75 AAILRRWFDLVIANSDDLALILTTEQGKPLAEAKGEIAYAASFIEWFAEEGKRVAGDTLP 134 Query: 134 LPGGS-FGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLL 192 P + +EP+GVC I WN+P + + K PALA G +V KP+ TP SAL + Sbjct: 135 TPDANKRIVVVKEPIGVCAAITPWNFPAAMIARKVGPALAAGCPIVVKPAESTPFSALAM 194 Query: 193 AEIYSEAGVPPGLFNVVQGGA-ATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPV 251 A + AGVP G+ +VV G A G + +P V K+SFTGS G +M SA +K + Sbjct: 195 AFLAERAGVPKGVLSVVIGDPKAIGTEITSNPIVRKLSFTGSTAVGRLLMAQSAPTVKKL 254 Query: 252 TLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQ 311 TLELGG +P I+F D D++ AV+GA+ + + GQ C R FV + + D F +++ Sbjct: 255 TLELGGNAPFIVFDDADLDAAVEGAIASKYRNNGQTCVCTNRFFVHERVYDAFADKLAAA 314 Query: 312 TQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGY 371 ++K+G +GPLIN +++V + A +GA ++ GG + Sbjct: 315 VSKLKVGRGTESGATLGPLINEAAVKKVESHIADALAKGASLMTGGKRHALGHG------ 368 Query: 372 YMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRA 431 + P VLT + DM KEE FGP+ + F +E E++ ANDT FGLAA +++RDI R Sbjct: 369 FFEPTVLTGVKPDMDVAKEETFGPLAPLFRFASEEELVRLANDTEFGLAAYLYSRDIGRV 428 Query: 432 HRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCV 485 RV L+ G IN +S PFGG K+SG GRE I+ Y +K +CV Sbjct: 429 WRVAEALEYGMVGINTGLISNEVAPFGGVKQSGLGREGSHYGIDDYVVIKYLCV 482 >4U3W-A nrPDB Length = 505 Score = 526 bits (1355), Expect = e-150, Method: Composition-based stats. Identities = 189/483 (39%), Positives = 275/483 (56%), Gaps = 12/483 (2%) Query: 13 NYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI-WSQKSGM 71 +Y G V + T P GR +A + V+ AVQ A AA K W + Sbjct: 26 HYINGEFV---ASGTTFPNLSPVDGRKLADVCEADAALVDSAVQAAHAAQKAGWRDTTPA 82 Query: 72 ERCRILLEAARIIREREDEIATMECINNGKSIFEAR-LDIDISWQCLEYYAGLAASMAGE 130 +R L + A I R DE E + G+ + +AR LDI +A L + +GE Sbjct: 83 QRAAWLHKIADGIEARFDEFVAAEVADTGRPVAQARTLDIARGIANFRTFADLVRTASGE 142 Query: 131 HIQL----PGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTP 186 + + Y R+PLGV I WN P + +WK APALA GN +V KPS TP Sbjct: 143 YFETHAADGSELINYVTRKPLGVIGIISPWNLPLLLFTWKVAPALAMGNCVVAKPSEETP 202 Query: 187 VSALLLAEIYSEAGVPPGLFNVVQGGA--ATGQFLCQHPDVAKVSFTGSVPTGMKIMEMS 244 SA LLAE+ + G+PPG+FN++ G A G+FL +HPD++ ++FTG TG IM+ Sbjct: 203 SSATLLAEVMHDVGLPPGVFNLIHGHGQNAAGEFLTRHPDISAITFTGESRTGSTIMKAV 262 Query: 245 AKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKF 304 A G+K V+ ELGGK+ ++F+D D + AV G L ++F GQVC RV+V++ I ++F Sbjct: 263 ADGVKEVSFELGGKNAAVVFADADFDAAVAGVLRSSFTNAGQVCLCSERVYVERPIFERF 322 Query: 305 TEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPED 364 + +Q Q +++G P T MGPLI+R H ++VL + ++A E+GA V+ GG D Sbjct: 323 VAALKEQAQALRVGAPEDPATTMGPLISRGHRDKVLSYFRLAVEEGATVVTGGGAPSFGD 382 Query: 365 PKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVF 424 + DG ++ P + T D CV+EEIFGPV I FD EAEV++R ND+ +GLAA ++ Sbjct: 383 AR-DDGAFVMPTIWTGLPDSARCVREEIFGPVCHIAPFDDEAEVVKRVNDSAYGLAASIW 441 Query: 425 TRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVC 484 T + R HRV +++ G ++N + V + PFGG K SG GRE GR ++++YS+L VC Sbjct: 442 TTQLARGHRVAKQIETGIVWVNAWFVRDLRTPFGGTKLSGLGREGGRHSLDFYSELTNVC 501 Query: 485 VEM 487 V + Sbjct: 502 VRI 504 >2HG2-A nrPDB Length = 479 Score = 524 bits (1350), Expect = e-149, Method: Composition-based stats. Identities = 172/485 (35%), Positives = 255/485 (52%), Gaps = 18/485 (3%) Query: 5 TFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI 64 ++ Q + +RG A ++ PAT VI+ ++ A+ A+ A Sbjct: 9 MYIDGQFVTWRGDAWID---------VVNPATEAVISRIPDGQAEDARKAIDAAERAQPE 59 Query: 65 WSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLA 124 W +ER L + + IRER EI+ + GK A +++ + ++Y A A Sbjct: 60 WEALPAIERASWLRKISAGIRERASEISALIVEEGGKIQQLAEVEVAFTADYIDYMAEWA 119 Query: 125 ASMAGEHIQLP-GGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSP 183 GE IQ G + LGV GI WN+PF + + K APAL GN +V KPS Sbjct: 120 RRYEGEIIQSDRPGENILLFKRALGVTTGILPWNFPFFLIARKMAPALLTGNTIVIKPSE 179 Query: 184 FTPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIME 242 FTP +A+ A+I E G+P G+FN+V G G GQ L +P VA VS TGSV G KIM Sbjct: 180 FTPNNAIAFAKIVDEIGLPRGVFNLVLGRGETVGQELAGNPKVAMVSMTGSVSAGEKIMA 239 Query: 243 MSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILD 302 +AK I V LELGGK+P I+ D D+ AVK + + + GQVC RV+VQK I D Sbjct: 240 TAAKNITKVCLELGGKAPAIVMDDADLELAVKAIVDSRVINSGQVCNCAERVYVQKGIYD 299 Query: 303 KFTEEVVKQTQRIKIGDPLLE-DTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYV 361 +F + + Q ++ G+P D MGPLIN LERV V A E+GA+V GG Sbjct: 300 QFVNRLGEAMQAVQFGNPAERNDIAMGPLINAAALERVEQKVARAVEEGARVAFGGK--- 356 Query: 362 PEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAA 421 GYY P +L + R +M+ + EE FGPV+ +++FDT + + AND+ +GL + Sbjct: 357 ---AVEGKGYYYPPTLLLDVRQEMSIMHEETFGPVLPVVAFDTLEDAISMANDSDYGLTS 413 Query: 422 GVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLK 481 ++T+++ A + + L+ G +IN N ++ G++KSG G +G+ + Y Q + Sbjct: 414 SIYTQNLNVAMKAIKGLKFGETYINRENFEAMQGFHAGWRKSGIGGADGKHGLHEYLQTQ 473 Query: 482 TVCVE 486 V ++ Sbjct: 474 VVYLQ 478 >3TY7-A nrPDB Length = 478 Score = 522 bits (1346), Expect = e-148, Method: Composition-based stats. Identities = 169/473 (35%), Positives = 258/473 (54%), Gaps = 9/473 (1%) Query: 12 LNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGM 71 Y G VE ++++ T + PAT VI + +V+ AV+ A + + S Sbjct: 9 KQYINGEWVE-SNSNETIEVINPATEEVIGKVAKGNKADVDKAVEAADDVYLEFRHTSVK 67 Query: 72 ERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEH 131 ER +L + + R+D+I G + + + L ++ ++ Sbjct: 68 ERQALLDKIVKEYENRKDDIVQAITDELGAPL--SLSERVHYQMGLNHFVAARDALDNYE 125 Query: 132 IQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALL 191 + G +E +GV I WN+P S K A A A G+ +V KPS TP +A++ Sbjct: 126 FEERRGDD-LVVKEAIGVSGLITPWNFPTNQTSLKLAAAFAAGSPVVLKPSEETPFAAVI 184 Query: 192 LAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKP 250 LAEI+ + GVP G+FN+V G GA G L +HP V +SFTGS PTG KIME +AK K Sbjct: 185 LAEIFDKVGVPKGVFNLVNGDGAGVGNPLSEHPKVRMMSFTGSGPTGSKIMEKAAKDFKK 244 Query: 251 VTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVK 310 V+LELGGKSP I+ D D+ A K GQVC GTRV V +I D F E+ + Sbjct: 245 VSLELGGKSPYIVLDDVDIKEAAKATTGKVVNNTGQVCTAGTRVLVPNKIKDAFLAELKE 304 Query: 311 QTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDG 370 Q ++++G+P + T++GP+I++ ++V ++ E+GA++ GG + L+ G Sbjct: 305 QFSQVRVGNPREDGTQVGPIISKKQFDQVQNYINKGIEEGAELFYGG---PGKPEGLEKG 361 Query: 371 YYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQR 430 Y+ RP + N + MT +EEIFGPVMS+++++ E ++ ANDT +GLA V +D + Sbjct: 362 YFARPTIFINVDNQMTIAQEEIFGPVMSVITYNDLDEAIQIANDTKYGLAGYVIGKDKET 421 Query: 431 AHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTV 483 H+V ++AGT IN P +LPFGGYK+SG GRE G IE + ++K++ Sbjct: 422 LHKVARSIEAGTVEINEAGRKP-DLPFGGYKQSGLGREWGDYGIEEFLEVKSI 473 >3EK1-A nrPDB Length = 504 Score = 522 bits (1346), Expect = e-148, Method: Composition-based stats. Identities = 164/472 (34%), Positives = 249/472 (52%), Gaps = 11/472 (2%) Query: 15 RGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERC 74 G ++ AD + T K PA G VI T + A+ + A W+ K+ ER Sbjct: 37 VNGRWIDAADGT-TIKVTNPADGSVIGTVPSLSVATIKEAIDASAKALSGWAAKTAKERA 95 Query: 75 RILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQL 134 IL + +I D+IA + GK + EAR ++ + +E++A A + G+ I Sbjct: 96 GILRKWFDLIIANADDIALIMTSEQGKPLAEARGEVLYAASFIEWFAEEAKRVYGDTIPA 155 Query: 135 PG-GSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLA 193 P G R+P+GV I WN+P + + K+APALA G M+ +P+ TP++AL L Sbjct: 156 PQNGQRLTVIRQPVGVTAAITPWNFPAAMITRKAAPALAAGCTMIVRPADLTPLTALALG 215 Query: 194 EIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVT 252 + +AG+P G+ +V G G L + V K+SFTGS G +M A IK ++ Sbjct: 216 VLAEKAGIPAGVLQIVTGKAREIGAELTSNDTVRKLSFTGSTEVGRLLMAQCAPTIKRIS 275 Query: 253 LELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQT 312 LELGG +P I+F D D++ AV GA+++ + GQ C R++VQ+ + DKF E++ + Sbjct: 276 LELGGNAPFIVFDDADLDAAVDGAMVSKYRNAGQTCVCANRIYVQRGVYDKFAEKLAAKV 335 Query: 313 QRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYY 372 + +K+G+ +GP+I + +V ++ A +GAK++ GG G + Sbjct: 336 KELKVGNGTEPGVVIGPMIEEKAITKVKAHIEDAVSKGAKLITGGKEL--------GGLF 387 Query: 373 MRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAH 432 P +LT DM KEE FGP+ + +FDTE EV+ +ANDT FGLAA +T + RA Sbjct: 388 FEPGILTGVTSDMLVAKEETFGPLAPLFAFDTEEEVIAQANDTIFGLAAYFYTENFSRAI 447 Query: 433 RVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVC 484 RV L+ G N +S PFGG K+SG GRE + IE Y + K +C Sbjct: 448 RVSEALEYGMVGHNTGLISNEVAPFGGVKQSGLGREGSKYGIEEYLETKYIC 499 >3K2W-A nrPDB Length = 497 Score = 519 bits (1338), Expect = e-148, Method: Composition-based stats. Identities = 158/477 (33%), Positives = 257/477 (53%), Gaps = 5/477 (1%) Query: 12 LNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGM 71 +N+ GG V P++ S T P+TG+VI + + A++ A+AA K W++ + Sbjct: 14 VNFIGGQYV-PSNESDTIDILSPSTGKVIGEIPAGCKADAENALEVAQAAQKAWAKLTAR 72 Query: 72 ERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEH 131 R +L A IRE + +A M GK + A +++D++ ++Y A ++ G+ Sbjct: 73 TRQNMLRTFANKIRENKHILAPMLVAEQGKLLSVAEMEVDVTATFIDYGCDNALTIEGDI 132 Query: 132 IQLP-GGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSAL 190 + Y + P GV VGI AWN+P +A K PAL GN MV KP+ TP++ Sbjct: 133 LPSDNQDEKIYIHKVPRGVVVGITAWNFPLALAGRKIGPALITGNTMVLKPTQETPLATT 192 Query: 191 LLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIK 249 L I EAG+P G+ NV+ G G+ GQ LC+ P ++ TGS G +I + SA+ + Sbjct: 193 ELGRIAKEAGLPDGVLNVINGTGSVVGQTLCESPITKMITMTGSTVAGKQIYKTSAEYMT 252 Query: 250 PVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVV 309 PV LELGGK+P+++ D D++ A + AL F GQVC R++V + D+F + + Sbjct: 253 PVMLELGGKAPMVVMDDADLDKAAEDALWGRFANCGQVCTCVERLYVHASVYDEFMAKFL 312 Query: 310 KQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKD 369 + +K+GDP+ D++MGP N+ ++ + V A +QGA V GG E + Sbjct: 313 PLVKGLKVGDPMDADSQMGPKCNQREIDNIDHIVHEAIKQGATVATGGKTATVE--GFEG 370 Query: 370 GYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQ 429 G + P VL + + D V EE FGP++ I+ + + +E ND+ +GL+A V T+ Sbjct: 371 GCWYEPTVLVDVKQDNIVVHEETFGPILPIVKVSSMEQAIEFCNDSIYGLSAYVHTQSFA 430 Query: 430 RAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 486 ++ +++L+ G +IN + G+K+SGFG E+G+ +E Y + KTV + Sbjct: 431 NINQAISDLEVGEVYINRGMGEQHQGFHNGWKQSGFGGEDGKFGLEQYLEKKTVYIN 487 >1WNB-A nrPDB Length = 495 Score = 517 bits (1332), Expect = e-147, Method: Composition-based stats. Identities = 180/493 (36%), Positives = 261/493 (52%), Gaps = 16/493 (3%) Query: 2 STGTFVVS---QPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNA 58 ST + + Q G V + + + PATG V+ + ++V+ AV+ A Sbjct: 12 STSLYKKAGLMQHKLLINGELV--SGEGEKQPVYNPATGDVLLEIAEASAEQVDAAVRAA 69 Query: 59 KAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARL-DIDISWQCL 117 AAF W Q + R LL+ A +I E A +E N GK + A +I Sbjct: 70 DAAFAEWGQTTPKVRAECLLKLADVIEENGQVFAELESRNCGKPLHSAFNDEIPAIVDVF 129 Query: 118 EYYAGLAASMAGEHI-QLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNA 176 ++AG A + G + G RR+PLGV I WNYP +A+WK APALA GN Sbjct: 130 RFFAGAARCLNGLAAGEYLEGHTSMIRRDPLGVVASIAPWNYPLMMAAWKLAPALAAGNC 189 Query: 177 MVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVP 235 +V KPS TP++AL LAE+ + P G+ N++ G G G L HP V VS TGS+ Sbjct: 190 VVLKPSEITPLTALKLAELAKDI-FPAGVVNILFGRGKTVGDPLTGHPKVRMVSLTGSIA 248 Query: 236 TGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVF 295 TG I+ +A IK +ELGGK+P+I+F D D+ V+G + GQ C R++ Sbjct: 249 TGEHIISHTASSIKRTHMELGGKAPVIVFDDADIEAVVEGVRTFGYYNAGQDCTAACRIY 308 Query: 296 VQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGA-KVL 354 QK I D E++ +K G P E T +GPL + HLERV V+ AK G KV+ Sbjct: 309 AQKGIYDTLVEKLGAAVATLKSGAPDDESTELGPLSSLAHLERVGKAVEEAKATGHIKVI 368 Query: 355 CGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERAND 414 GG+ + +GYY P +L D V++E+FGPV+S+ FD E +V+ AND Sbjct: 369 TGGE------KRKGNGYYYAPTLLAGALQDDAIVQKEVFGPVVSVTPFDNEEQVVNWAND 422 Query: 415 TTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTI 474 + +GLA+ V+T+D+ RAHRV A LQ G ++N + + E+P GG K SG+G++ + Sbjct: 423 SQYGLASSVWTKDVGRAHRVSARLQYGCTWVNTHFMLVSEMPHGGQKLSGYGKDMSLYGL 482 Query: 475 EYYSQLKTVCVEM 487 E Y+ ++ V V+ Sbjct: 483 EDYTVVRHVMVKH 495 >6C43-A nrPDB Length = 477 Score = 515 bits (1327), Expect = e-146, Method: Composition-based stats. Identities = 173/482 (35%), Positives = 253/482 (52%), Gaps = 13/482 (2%) Query: 10 QPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKS 69 Q G V+ + + PATG VI + +V+ AVQ A AF W Q + Sbjct: 5 QYQLLINGVLVDG--EGERQSVYNPATGEVILEIAEASPAQVDAAVQAADNAFAEWGQTT 62 Query: 70 GMERCRILLEAARIIREREDEIATMECINNGKSIFEARL-DIDISWQCLEYYAGLAASMA 128 R LL+ A I + E A +E N GK + +I ++AG A ++ Sbjct: 63 PKARAECLLKLADSIEQNALEFARLESQNCGKPLHCVINDEIPAIVDVFRFFAGAARCLS 122 Query: 129 GEHI-QLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPV 187 G + G RR+P+GV I WNYP +A+WK APALA GN +V KPS TP+ Sbjct: 123 GLAAGEYLEGHTSMIRRDPIGVVASIAPWNYPLMMAAWKLAPALAAGNCVVIKPSEITPL 182 Query: 188 SALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK 246 +AL LA + + PPG+ NV+ G G G L H V VS TGS+ TG I+ +A Sbjct: 183 TALKLAVLAKDI-FPPGVLNVLFGRGQTVGDVLTGHEKVRMVSLTGSIATGEHILRHTAP 241 Query: 247 GIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTE 306 IK +ELGGK+P+I+F D D++ +G F GQ C R++ Q+ I D E Sbjct: 242 AIKRTHMELGGKAPVIVFDDADLDAVAQGVRTFGFYNAGQDCTAACRIYAQRGIYDALVE 301 Query: 307 EVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKE-QGAKVLCGGDIYVPEDP 365 ++ +K+G P E T +GPL + HL+RV V+ AK +V+ GG Sbjct: 302 KLGNAVSSLKMGAPEDESTELGPLSSLAHLKRVTAAVEEAKALSHIRVITGGS------Q 355 Query: 366 KLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFT 425 GYY P +L + + + V+ E+FGPV+SI FD E +VL AND+ +GLA+ V+T Sbjct: 356 TEGKGYYFAPTLLADAKQEDAIVQREVFGPVVSITVFDDEDQVLRWANDSRYGLASSVWT 415 Query: 426 RDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCV 485 +D+ RAHR+ A LQ G +IN + + E+P GG K+SG+G++ +E Y+ ++ + V Sbjct: 416 QDVGRAHRLSARLQYGCTWINTHFMLVSEMPHGGQKQSGYGKDMSLYGLEDYTLVRHIMV 475 Query: 486 EM 487 + Sbjct: 476 KH 477 >1T90-A nrPDB Length = 486 Score = 512 bits (1320), Expect = e-145, Method: Composition-based stats. Identities = 144/482 (29%), Positives = 247/482 (51%), Gaps = 10/482 (2%) Query: 10 QPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKS 69 + NY G VE + E PAT V+ S +++++ A Q A AFK WS+ + Sbjct: 5 KLKNYINGEWVE-SKTDQYEDVVNPATKEVLCQVPISTKEDIDYAAQTAAEAFKTWSKVA 63 Query: 70 GMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAG 129 R RIL +++ + ++E+A + I NGK+ EA ++ + +E+ AG + M G Sbjct: 64 VPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEALGEVGRGIENVEFAAGAPSLMMG 123 Query: 130 EHI-QLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVS 188 + + + R P+GV GI +N+P + W A+A GN + KPS TP+ Sbjct: 124 DSLASIATDVEAANYRYPIGVVGGIAPFNFPMMVPCWMFPMAIALGNTFILKPSERTPLL 183 Query: 189 ALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGI 248 L E++ +AG+P G+FNVV G + +HP++ +SF GS P G + + ++ + Sbjct: 184 TEKLVELFEKAGLPKGVFNVVYGAHDVVNGILEHPEIKAISFVGSKPVGEYVYKKGSENL 243 Query: 249 KPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEV 308 K V G K+ I+ +D ++ + V + A F + G+ C V V++ I D+F ++ Sbjct: 244 KRVQSLTGAKNHTIVLNDANLEDTVTNIVGAAFGSAGERCMACAVVTVEEGIADEFMAKL 303 Query: 309 VKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLK 368 ++ IKIG+ L + +GP+I + +R L +++ E+GA+++C G V +D Sbjct: 304 QEKVADIKIGNGLDDGVFLGPVIREDNKKRTLSYIEKGLEEGARLVCDGRENVSDD---- 359 Query: 369 DGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDI 428 GY++ P + N +MT K+EIF PV+S++ E +E AN + F A +FT + Sbjct: 360 -GYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIRVKNLKEAIEIANKSEFANGACLFTSNS 418 Query: 429 QRAHRVVAELQAGTCFINNYNVSPVE-LPFGGYKKSGFG--RENGRVTIEYYSQLKTVCV 485 + AG IN +P+ PF G+K S FG NG+ ++++Y++ K V Sbjct: 419 NAIRYFRENIDAGMLGINLGVPAPMAFFPFSGWKSSFFGTLHANGKDSVDFYTRKKVVTA 478 Query: 486 EM 487 Sbjct: 479 RY 480 >5EUY-A nrPDB Length = 491 Score = 511 bits (1317), Expect = e-145, Method: Composition-based stats. Identities = 151/480 (31%), Positives = 242/480 (50%), Gaps = 14/480 (2%) Query: 13 NYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGME 72 NY G EP+ + K P G IA SG ++ A+ +A A K W+ + Sbjct: 11 NYINGEFKEPSTGAFQVKT-SPVDGSKIAEVPRSGREDAREAIDSAFEALKAWANIPAIR 69 Query: 73 RCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHI 132 R L + + R+ +++ + + G + + ++ + + ++ A LA G + Sbjct: 70 RAEYLYKMLEVFRQMKEDFMKILTVEGGGTYRKVWGEVVFTERLIQNAAELARHYQGRVL 129 Query: 133 QLPGG-SFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALL 191 Q + + GV I WNYP I+ K A LA GN +V+KP+ TPV+ L Sbjct: 130 QSDSESTISVVFKRSKGVVGVITPWNYPLSISMKKIAHTLAVGNTVVYKPASDTPVTGWL 189 Query: 192 LAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKP 250 +A++ ++AG+P G+FN+V G G G+ + H VA V+FTG TG +I +A +K Sbjct: 190 IAQMVAKAGLPKGVFNLVIGPGPVVGEEIVTHKRVAHVTFTGESSTGREIAAKAAGTLKT 249 Query: 251 VTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVK 310 VTLELGG PLII D D++ A + A+ A+ QGQ+C + R+ V K + DKF E V Sbjct: 250 VTLELGGSDPLIILDDVDVDYAARLAVFASLFHQGQICTSAKRIIVHKAVADKFIERYVH 309 Query: 311 QTQRIKIGDPL-LEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKD 369 + ++I DP E +GPLIN + + FV A +G ++L GG + Sbjct: 310 YVKMLRIDDPRKDEKVDLGPLINERQVALMKEFVDDAVSRGGRLLIGGRSW--------- 360 Query: 370 GYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQ 429 G + P + + + ++EE+FGPV I+ + + + +E ANDT +GL+ V T ++ Sbjct: 361 GNFFEPAIFVDVDRNFRIMREEVFGPVRPIVVVENDDQAVEVANDTDYGLSGAVLTNNVN 420 Query: 430 RAHRVVAELQAGTCFINNYNV-SPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMG 488 RA R+ +++G IN+ +PFGG K SG GRE G + + + V V + Sbjct: 421 RAFRIAEAVESGMFHINDVTFLEESHVPFGGIKASGVGREGGEWSFHETTYDRWVTVTLR 480 >3U4J-A nrPDB Length = 528 Score = 510 bits (1314), Expect = e-145, Method: Composition-based stats. Identities = 189/498 (37%), Positives = 275/498 (55%), Gaps = 11/498 (2%) Query: 2 STGTFVVSQPLNYRGGARVEPADASGTEKAFEP-ATGRVIATFTCSGEKEVNLAVQNAKA 60 + S+ G V+ A S T P G V+ T+ + +V AV A+ Sbjct: 14 DPRLRIKSRYQMLVDGKSVDAASGS-TIDRVSPGHAGEVVGTWPEASADDVRKAVAAARK 72 Query: 61 AFKI--WSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLE 118 AF W + SG ER R++ + A +I R++E+A +E + GK I +AR +I Sbjct: 73 AFDAGPWPRMSGAERSRLMFKVADLILARQEELALIESLEVGKPIAQARGEIGFCADLWS 132 Query: 119 YYAGLAASMAGE-HIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAM 177 Y AG A ++ G+ H + G REP+GV I WN+PF IAS + A+ G + Sbjct: 133 YAAGQARALEGQTHNNIGDDRLGLVLREPVGVVGIITPWNFPFIIASERVPWAIGSGCTV 192 Query: 178 VFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPT 236 V KPS FT +++ LAE+ EAG+P G+FNVV G G GQ L + P+V V+FTGSV Sbjct: 193 VLKPSEFTSGTSIRLAELAREAGIPDGVFNVVTGYGDPAGQVLAEDPNVDMVAFTGSVRV 252 Query: 237 GMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFV 296 G K+ E++A+ +K V LELGGK P I+F+D D++ A G + GQ C +G+R+ V Sbjct: 253 GTKLGEIAARTVKRVGLELGGKGPQIVFADADLDAAADGIAYGVYHNAGQCCISGSRLLV 312 Query: 297 QKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCG 356 Q+ I D E ++ ++++ GDPL E T++G +I+ H E+V +V GA++L G Sbjct: 313 QEGIRDALMERLLDISRKVAFGDPLNERTKIGAMISEAHAEKVHSYVTAGITSGAELLLG 372 Query: 357 GDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTT 416 G+ E G Y P V DM+ +EEIFGPV+S L+F T E + AN T Sbjct: 373 GERIGREA-----GLYYAPTVFAGVTPDMSIAREEIFGPVLSTLTFKTADEAVALANATE 427 Query: 417 FGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEY 476 FGL+A V++ +++ A + + ++AG C+IN+ ELP GGYKKSG GRE GR + Sbjct: 428 FGLSASVWSTNLETALQTIRRIRAGRCWINSVIDGTPELPIGGYKKSGLGRELGRYGFDE 487 Query: 477 YSQLKTVCVEMGDVESAF 494 YSQ K V V +G F Sbjct: 488 YSQFKGVHVTLGRPAPWF 505 >4F3X-A nrPDB Length = 498 Score = 508 bits (1308), Expect = e-144, Method: Composition-based stats. Identities = 157/483 (32%), Positives = 251/483 (51%), Gaps = 18/483 (3%) Query: 13 NYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGME 72 G+R E A E P TG I + +++ AV A+ AF WSQ + E Sbjct: 27 QLLIGSRFE-AGTEAEEHILNPRTGAGIIDLAEASHAQIDAAVDAAERAFVGWSQTTPAE 85 Query: 73 RCRILLEAARIIREREDEIATMECINNGKSIFEARL-DIDISWQCLEYYAGLAASMA--- 128 R LL+ A I + DE A +E +N GK I + ++ C ++AG ++ Sbjct: 86 RSNALLKIADAIEKEADEFAALEALNCGKPINAVKNDELPAIIDCWRFFAGAVRNLHAPA 145 Query: 129 -GEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPV 187 GE++ G RR+P+G+ I WNYP + +WK APA+ GN +VFKPS TP+ Sbjct: 146 AGEYLP---GHTSMIRRDPIGIVGSIAPWNYPLMMMAWKLAPAIGGGNTVVFKPSEQTPL 202 Query: 188 SALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK 246 +AL LA + ++ +P G+ NV+ G G G L HP V VS TG + TG K++ +AK Sbjct: 203 TALKLARLIADI-LPEGVVNVITGRGETVGNALINHPKVGMVSITGDIATGKKVLAAAAK 261 Query: 247 GIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTE 306 +K LELGGK+P+I++ D D+ V G + GQ C R++ + I +K Sbjct: 262 TVKRTHLELGGKAPVIVYGDADLEAVVNGIRTFGYYNAGQDCTAACRIYAEAGIYEKLVA 321 Query: 307 EVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQ-GAKVLCGGDIYVPEDP 365 ++ I+ + +GPLI+R +RV FV+ A +Q ++ GG E Sbjct: 322 DLTSAVSTIRYNLDDDTENEIGPLISRRQRDRVASFVERAADQKHIEITTGGRTGSDE-- 379 Query: 366 KLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFT 425 G++ +P V+ + V+ E+FGPV+S+ F + + + AND+ +GLA+ V+T Sbjct: 380 ----GFFFQPTVVAGATQEDEIVRREVFGPVVSVTRFTGKDDAVAWANDSDYGLASSVWT 435 Query: 426 RDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCV 485 +DI +A R + LQ G +IN + + E+P GG K+SG+G++ +E Y+ ++ + + Sbjct: 436 KDISKAMRAASRLQYGCTWINTHFMLTNEMPHGGIKQSGYGKDMSVYALEDYTAVRHIMI 495 Query: 486 EMG 488 G Sbjct: 496 NHG 498 >3I44-A nrPDB Length = 497 Score = 505 bits (1300), Expect = e-143, Method: Composition-based stats. Identities = 139/473 (29%), Positives = 231/473 (48%), Gaps = 8/473 (1%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMER 73 Y G +P+ +P+T A + ++ + A+ AK AF+ W S ER Sbjct: 29 YINGLWDDPSTPHDLY-VIDPSTEEACAVISLGSTRDADKAINAAKKAFQTWKTTSPHER 87 Query: 74 CRILLEAARIIREREDEIATMECINNGKSIFEAR-LDIDISWQCLEYYAGLAASMAGEHI 132 + + I +R ++A + G I A + + + + Sbjct: 88 LGFVEKILEIYEKRSSDMAKTISMEMGAPIDMALNAQTATGSSHIRNFIKAYKEFSFQEA 147 Query: 133 QLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLL 192 + G + +GV I WN+P + K PAL G MV KPS P+SA+L Sbjct: 148 LIEGNEQAILHYDAIGVVGLITPWNWPMNQVTLKVIPALLAGCTMVLKPSEIAPLSAMLF 207 Query: 193 AEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPV 251 AEI EA +P G+FN++ G GA G +L HPD+ +SFTGS G I + ++ +K V Sbjct: 208 AEILDEAALPSGVFNLINGDGANVGSYLSAHPDLEMISFTGSTRAGKDISKNASNTLKRV 267 Query: 252 TLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQ 311 LELGGK IIF+D D++ A++ + F GQ C TR+ V++ I DK + Sbjct: 268 CLELGGKGANIIFADADID-ALQRGVRHCFYNSGQSCNAPTRMLVEQAIYDKAIKTAKDI 326 Query: 312 TQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGY 371 ++ ++G +GP++++ +++ ++ ++GA ++ GG ++ GY Sbjct: 327 AEKTQVGPGHQTGNHIGPVVSKEQYDKIQDLIQSGIDEGATLVTGG---TGLPMGMERGY 383 Query: 372 YMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRA 431 Y+RP V + + M +EEIFGPV+S+L F+TE E + ANDT +GL + ++D + Sbjct: 384 YVRPTVFADVKPHMRIFREEIFGPVLSLLPFNTEDEAVTLANDTEYGLTNYIQSQDRSKC 443 Query: 432 HRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVC 484 R+ A++++G +N + + FGG K SG RE G I+ + K + Sbjct: 444 RRIAAQVRSGMVEVNGHELPGGSY-FGGVKFSGRAREGGLWGIKEFLDTKAIS 495 >4LIH-A nrPDB Length = 504 Score = 505 bits (1300), Expect = e-143, Method: Composition-based stats. Identities = 176/481 (36%), Positives = 272/481 (56%), Gaps = 13/481 (2%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI--WSQKSGM 71 + GA + A T P GRV+A GE +VN AV A+ AF W+ + Sbjct: 31 FIDGASRD-AHGGRTFDCVSPIDGRVLAKVADCGEADVNAAVAAARRAFDAGVWAGLNPR 89 Query: 72 ERCRILLEAARIIREREDEIATMECINNGKSIFEAR-LDIDISWQCLEYYAGLAASMAGE 130 R +LL A ++RE DE++ +E ++ GK I + +D+ + C+E++A + GE Sbjct: 90 ARKAVLLRWAALMREHLDELSLLETLDAGKPIGDTTTVDVPGAAYCVEWFAEAIDKVGGE 149 Query: 131 HIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSAL 190 G REP+GV + WN+P +A+WK PALA GN++V KPS +P++A+ Sbjct: 150 VAPADHHLVGLVTREPVGVVAAVVPWNFPILMAAWKFGPALAAGNSVVLKPSEKSPLTAI 209 Query: 191 LLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK-GIK 249 +A++ EAG+P G+FNVV G G+ L H DV ++FTGS G IM+ +A+ +K Sbjct: 210 RVAQLAFEAGIPAGVFNVVPGAGEPGKLLALHRDVDCIAFTGSTAVGKLIMQYAAQSNLK 269 Query: 250 PVTLELGGKSPLIIFSDC-DMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEV 308 LELGGKSP I+ DC D++ A + A A F G++C G+R+ V ++I D F E++ Sbjct: 270 RAWLELGGKSPNIVLPDCPDLDRAAQTAAGAIFYNMGEMCTAGSRLLVHRDIKDAFIEKL 329 Query: 309 VKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLK 368 V + G+PL MG +++ LERVLG+++ + +G +++ GG E Sbjct: 330 VAAARAYVPGNPLDPSVSMGAIVDGIQLERVLGYIEAGRGEG-RLVTGGARVNAE----T 384 Query: 369 DGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDI 428 G+Y+ P V + D +EEIFGPV+S++ FD E + ANDT +GLAA V+T ++ Sbjct: 385 GGFYVEPTVFE-VKPDAKIAREEIFGPVLSVIVFDDVDEAVRIANDTEYGLAAAVWTSNL 443 Query: 429 QRAHRVVAELQAGTCFINNYN-VSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 487 AH V L+AGT ++N Y+ + PFGGYK+SG GR+ +E Y++LK+ + + Sbjct: 444 TTAHDVSRRLRAGTVWVNCYDEGGDMNFPFGGYKQSGNGRDKSLHALEKYTELKSTLIRL 503 Query: 488 G 488 Sbjct: 504 R 504 >2W8P-A nrPDB Length = 487 Score = 499 bits (1285), Expect = e-141, Method: Composition-based stats. Identities = 160/477 (33%), Positives = 249/477 (52%), Gaps = 15/477 (3%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMER 73 + GG + A T +PA+G + G +E AV+ A AF W + S ER Sbjct: 16 FVGGRWLPAA---ATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKER 72 Query: 74 CRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQ 133 +L + ++ + +D++A + +GK + EA +I S LE+++ A + G+ I Sbjct: 73 SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIH 132 Query: 134 LPG-GSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLL 192 P ++P+GV I WN+P + + K ALA G +V KP+ TP SAL L Sbjct: 133 TPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALAL 192 Query: 193 AEIYSEAGVPPGLFNVVQ----GGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGI 248 AE+ S+AG+P G++NV+ G+ +C P V+K+SFTGS TG ++ +A + Sbjct: 193 AELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSV 252 Query: 249 KPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEV 308 K V++ELGG +P I+F +++ AV GA+ + F GQ + VQ+ I D F + Sbjct: 253 KRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTAVCSNQFLVQRGIHDAFVKAF 312 Query: 309 VKQTQR-IKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKL 367 + ++ +++G+ E T GPLIN +E+V V A +GA V+ GG + Sbjct: 313 AEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGK--- 369 Query: 368 KDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRD 427 + P +L N DM C EE FGP+ ++ FDTE E + AN GLA +++D Sbjct: 370 ---NFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQD 426 Query: 428 IQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVC 484 + RV +L+ G +N +S VE PFGG K+SG GRE + I+ Y +LK VC Sbjct: 427 PAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 483 >3QAN-A nrPDB Length = 538 Score = 498 bits (1284), Expect = e-141, Method: Composition-based stats. Identities = 141/482 (29%), Positives = 238/482 (49%), Gaps = 22/482 (4%) Query: 15 RGGARVEPADASGTEKAFEPA-TGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMER 73 G RV D +++ PA +++ + + + + A+Q+A AF+ W + ER Sbjct: 42 INGERVTTEDK---IQSWNPARKDQLVGSVSKANQDLAEKAIQSADEAFQTWRNVNPEER 98 Query: 74 CRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMA-GEHI 132 IL++AA IIR R+ E + GK EA D + LEYYA + G+ I Sbjct: 99 ANILVKAAAIIRRRKHEFSAWLVHEAGKPWKEADADTAEAIDFLEYYARQMIELNRGKEI 158 Query: 133 QLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLL 192 G P+GV V I WN+ I + + GN +V KP+ TPV A Sbjct: 159 LSRPGEQNRYFYTPMGVTVTISPWNFALAIMVGTAVAPIVTGNTVVLKPASTTPVVAAKF 218 Query: 193 AEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSA------ 245 E+ +AG+P G+ N V G GA G +L HP + ++FTGS G+++ E +A Sbjct: 219 VEVLEDAGLPKGVINYVPGSGAEVGDYLVDHPKTSLITFTGSKDVGVRLYERAAVVRPGQ 278 Query: 246 KGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFT 305 +K V +E+GGK +++ D D++ A + L++ F GQ C G+R + K++ D+ Sbjct: 279 NHLKRVIVEMGGKDTVVVDRDADLDLAAESILVSAFGFSGQKCSAGSRAVIHKDVYDEVL 338 Query: 306 EEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDP 365 E+ V + + +GDP D MGP+I+ E+++ ++++ K++G +++ GG+ Sbjct: 339 EKTVALAKNLTVGDPTNRDNYMGPVIDEKAFEKIMSYIEIGKKEG-RLMTGGE------G 391 Query: 366 KLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFT 425 G++++P ++ + + ++EEIFGPV++ + LE AN+T +GL V T Sbjct: 392 DSSTGFFIQPTIIADLDPEAVIMQEEIFGPVVAFSKANDFDHALEIANNTEYGLTGAVIT 451 Query: 426 RDIQRAHRVVAELQAGTCFINNYNVSPV--ELPFGGYKKSGF-GRENGRVTIEYYSQLKT 482 R+ + E G + N + PFGG+K SG + G + + Q KT Sbjct: 452 RNRAHIEQAKREFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQAKT 511 Query: 483 VC 484 V Sbjct: 512 VS 513 >5TJR-A nrPDB Length = 531 Score = 493 bits (1269), Expect = e-140, Method: Composition-based stats. Identities = 139/487 (28%), Positives = 235/487 (48%), Gaps = 9/487 (1%) Query: 12 LNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGM 71 + GG + AD T F P+TG + + + + A+ AKAAF W Sbjct: 38 KHLIGGELI--ADTGRTADVFNPSTGEAVRKVPLADRETMQQAIDAAKAAFPAWRNTPPA 95 Query: 72 ERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEH 131 +R ++L +++ E+ I + +GK+I +A ++ + +EY + GE+ Sbjct: 96 KRAQVLFRFKQLLEANEERIVKLISEEHGKTIEDAAGELKRGIENVEYATAAPEILKGEY 155 Query: 132 IQLPGGSF-GYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSAL 190 + G + ++ +P+GV GI +N+P + W A+ACGN + KPS P S L Sbjct: 156 SRNVGPNIDAWSDFQPIGVVAGITPFNFPAMVPLWMYPLAIACGNTFILKPSERDPSSTL 215 Query: 191 LLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKP 250 L+AE++ EAG+P G+ NVV G L + P+V +SF GS P I K K Sbjct: 216 LIAELFHEAGLPKGVLNVVHGDKGAVDALIEAPEVKALSFVGSTPIAEYIYSEGTKRGKR 275 Query: 251 VTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGT-RVFVQKEILDKFTEEVV 309 V G K+ ++ D D++NAV + A + + G+ C + V V +I D +++V Sbjct: 276 VQALGGAKNHAVLMPDADLDNAVSALMGAAYGSCGERCMAISVAVCVGDQIADALVQKLV 335 Query: 310 KQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKD 369 Q + +KIG MGPL+ ++V G++ QGA+++ G Y + ++ Sbjct: 336 PQIKGLKIGAGTSCGLDMGPLVTGAARDKVTGYIDTGVAQGAELVVDGRGY--KVAGHEN 393 Query: 370 GYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQ 429 G+++ + +MT KEEIFGPV+ I+ ++ E ++ ND +G +FTRD + Sbjct: 394 GFFLGGTLFDRVTPEMTIYKEEIFGPVLCIVRVNSLEEAMQLINDHEYGNGTCIFTRDGE 453 Query: 430 RAHRVVAELQAGTCFINNYNVSPVE-LPFGGYKKSGFG--RENGRVTIEYYSQLKTVCVE 486 A E++ G +N PV FGG+K+S FG G + +Y++ K + Sbjct: 454 AARLFCDEIEVGMVGVNVPLPVPVAYHSFGGWKRSLFGDLHAYGPDGVRFYTKRKAITQR 513 Query: 487 MGDVESA 493 +S Sbjct: 514 WPQRKSH 520 >5X5U-A nrPDB Length = 505 Score = 492 bits (1267), Expect = e-139, Method: Composition-based stats. Identities = 158/483 (32%), Positives = 236/483 (48%), Gaps = 11/483 (2%) Query: 5 TFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI 64 T+ +Q L G V+ A + T PATG+ I +G +++ A+ A++ F+ Sbjct: 29 TYTDTQLL--IDGEWVD-AASGKTIDVVNPATGKPIGRVAHAGIADLDRALAAAQSGFEA 85 Query: 65 WSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLA 124 W + ER + +AA ++RER D IA + GK + EAR+++ + +E++A Sbjct: 86 WRKVPAHERAATMRKAAALVRERADAIAQLMTQEQGKPLTEARVEVLSAADIIEWFADEG 145 Query: 125 ASMAGEHIQLPG-GSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSP 183 + G + G+ +EP+G WN+P K + ALA G + + K Sbjct: 146 RRVYGRIVPPRNLGAQQTVVKEPVGPVAAFTPWNFPVNQVVRKLSAALATGCSFLVKAPE 205 Query: 184 FTPVSALLLAEIYSEAGVPPGLFNVVQGGA-ATGQFLCQHPDVAKVSFTGSVPTGMKIME 242 TP S L + +AGVP G+ +V G +L HP + KV+FTGS P G ++ Sbjct: 206 ETPASPAALLRAFVDAGVPAGVIGLVYGDPAEISSYLIPHPVIRKVTFTGSTPVGKQLAS 265 Query: 243 MSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILD 302 ++ +K T+ELGG +P+I+ D D+ AVK A A F GQVC + TR V I D Sbjct: 266 LAGLHMKRATMELGGHAPVIVAEDADVALAVKAAGGAKFRNAGQVCISPTRFLVHNSIRD 325 Query: 303 KFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVP 362 +FT +VK + +K+G+ L E T +G L N L + + A++ GA + GG+ Sbjct: 326 EFTRALVKHAEGLKVGNGLEEGTTLGALANPRRLTAMASVIDNARKVGASIETGGERIGS 385 Query: 363 EDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAG 422 E G + P V+ N D E FGPV +I FD E + AN FGLA Sbjct: 386 E------GNFFAPTVIANVPLDADVFNNEPFGPVAAIRGFDKLEEAIAEANRLPFGLAGY 439 Query: 423 VFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKT 482 FTR H + L+ G +IN E+PFGG K SG+G E G +E Y K+ Sbjct: 440 AFTRSFANVHLLTQRLEVGMLWINQPATPWPEMPFGGVKDSGYGSEGGPEALEPYLVTKS 499 Query: 483 VCV 485 V V Sbjct: 500 VTV 502 >4ZZ7-A nrPDB Length = 501 Score = 492 bits (1267), Expect = e-139, Method: Composition-based stats. Identities = 139/477 (29%), Positives = 228/477 (47%), Gaps = 9/477 (1%) Query: 13 NYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGME 72 + G V + + ++ F PATG + + K V A+ A+ AF W ++ Sbjct: 9 HLINGQLVT--ENTRSQNVFNPATGEIGKQLDLASTKTVEQAISAAQHAFPTWRNTPPLK 66 Query: 73 RCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHI 132 R R++ ++ + DEI + +GK +A ++ + +EY G + GEH Sbjct: 67 RARVMFRFKELLEQHADEICRLIGEEHGKIAHDAMGELQRGIENVEYACGAPELLKGEHS 126 Query: 133 QLPG-GSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALL 191 + G G ++ +P+GV GI +N+P + W A+ CGN V KPS P S L Sbjct: 127 RNVGPGIDSWSEFQPMGVVAGITPFNFPVMVPLWMFPMAIVCGNCFVLKPSERDPSSTLY 186 Query: 192 LAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPV 251 +A++ EAG+P G+ NVV G L V VSF GS P I ++ K Sbjct: 187 IAQLLQEAGLPDGVMNVVNGDKEAVDALLHDDRVKAVSFVGSTPIAEYIYRTASANGKRC 246 Query: 252 TLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGT-RVFVQKEILDKFTEEVVK 310 G K+ I+ D DM+NAV L A F + G+ C + V V D ++ + Sbjct: 247 QALGGAKNHAIVMPDADMDNAVNQLLGAAFGSSGERCMALSVAVAVGDAAGDALVSKMTQ 306 Query: 311 QTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDG 370 Q++K+G GP+I R H E+V+G++ A++QGA ++ G P+ P ++G Sbjct: 307 AMQKLKVGPSTDSGNDFGPVITRQHQEKVIGYINSAEQQGATIVVDGR--QPKVPNHENG 364 Query: 371 YYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQR 430 +++ ++ + +MT +EEIFGPV+ ++ T + ++ + +G +FTRD + Sbjct: 365 FFVGGTLIDHVTPEMTSYQEEIFGPVLQVVRVATMQDAMDLIDAHEYGNGTCIFTRDGEA 424 Query: 431 AHRVVAELQAGTCFINNYNVSPVE-LPFGGYKKSGFG--RENGRVTIEYYSQLKTVC 484 A +Q G IN PV FGG+K+S FG G + +Y++ KTV Sbjct: 425 ARYFSDNIQVGMVGINIPLPVPVAYHSFGGWKRSLFGDLHAYGPDAVRFYTKRKTVT 481 >3RJL-A nrPDB Length = 538 Score = 492 bits (1266), Expect = e-139, Method: Composition-based stats. Identities = 139/482 (28%), Positives = 228/482 (47%), Gaps = 22/482 (4%) Query: 15 RGGARVEPADASGTEKAFEPAT-GRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMER 73 G R E + + PA V+ T + + + A+Q A AF+ W ER Sbjct: 42 IDGERYETENK---IVSINPANKEEVVGTVSKATQDHAEKAIQAAAKAFETWRYTDPEER 98 Query: 74 CRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMA-GEHI 132 +L A +R ++ E + + GK EA D + +EYYA +A G+ + Sbjct: 99 AAVLFRAVAKVRRKKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMIELAKGKPV 158 Query: 133 QLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLL 192 G P GV V I WN+ F I + + + GN +V KP+ PV A Sbjct: 159 NSREGERNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASAAPVIAAKF 218 Query: 193 AEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK----- 246 E+ E+G+P G+ N V G GA G +L HP + ++FTGS G +I E +AK Sbjct: 219 VEVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSIITFTGSREVGTRIFERAAKVQPGQ 278 Query: 247 -GIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFT 305 +K V E+GGK +++ DCD+ A + + F GQ C G+R V +++ D+ Sbjct: 279 THLKQVIAEMGGKDTVVVDEDCDIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYDEVL 338 Query: 306 EEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDP 365 + V++ T+ K+G+P D MGP+I++ +++ ++++ KE+G +++ GG Sbjct: 339 KRVIEITESKKVGEPDSADVYMGPVIDQASFNKIMDYIEIGKEEG-RLVSGGK------G 391 Query: 366 KLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFT 425 GY++ P + + ++EEIFGPV++ + E LE AN+T +GL V T Sbjct: 392 DDSKGYFIEPTIFADLDPKARLMQEEIFGPVVAFSKVSSFDEALEVANNTEYGLTGAVIT 451 Query: 426 RDIQRAHRVVAELQAGTCFINNYNVSPV--ELPFGGYKKSGF-GRENGRVTIEYYSQLKT 482 ++ +R E G + N + PFGG+K SG + G + + Q KT Sbjct: 452 KNRDHINRAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQAKT 511 Query: 483 VC 484 + Sbjct: 512 IS 513 >3B4W-A nrPDB Length = 495 Score = 490 bits (1263), Expect = e-139, Method: Composition-based stats. Identities = 162/479 (33%), Positives = 254/479 (53%), Gaps = 11/479 (2%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFK--IWSQKSGM 71 + GG +P+ S + PATG + + +V+ AV A+AAF W Sbjct: 12 FIGGKWTKPS-TSDVIEVRCPATGEYVGKVPMAAAADVDAAVAAARAAFDNGPWPSTPPH 70 Query: 72 ERCRILLEAARIIREREDEIATMECINNGKS--IFEARLDIDISWQCLEYYAGLAASMAG 129 ER ++ A +++ ER+D + G+ I E + + Y+AG A + Sbjct: 71 ERAAVIAAAVKMLAERKDLFTKLLAAETGQPPTIIETMHWMGSM-GAMNYFAGAADKVTW 129 Query: 130 EHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSA 189 + REP+GV I AWN P +A K APAL G +V KP+ TP++A Sbjct: 130 TETRTGSYGQSIVSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAETPLTA 189 Query: 190 LLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIK 249 LAE+++E G+P G+ +VV GG TGQ L +PD+ +FTGS G ++ +A+ +K Sbjct: 190 NALAEVFAEVGLPEGVLSVVPGGIETGQALTSNPDIDMFTFTGSSAVGREVGRRAAEMLK 249 Query: 250 PVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVV 309 P TLELGGKS II D D+ A+ + + + GQ C N TR+ + D+ V Sbjct: 250 PCTLELGGKSAAIILEDVDLAAAIPMMVFSGVMNAGQGCVNQTRILAPRSRYDEIVAAVT 309 Query: 310 KQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKD 369 + +G P ++GPLI+ RV G++ E+GA+++CGG L + Sbjct: 310 NFVTALPVGPPSDPAAQIGPLISEKQRTRVEGYIAKGIEEGARLVCGGGR----PEGLDN 365 Query: 370 GYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQ 429 G++++P V + + MT +EEIFGPV++I+ +DTE + + AND+ +GLA V+T D+ Sbjct: 366 GFFIQPTVFADVDNKMTIAQEEIFGPVLAIIPYDTEEDAIAIANDSVYGLAGSVWTTDVP 425 Query: 430 RAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMG 488 + ++ +++ GT IN + PFGGYK SG GRENG +E+++Q K+V + MG Sbjct: 426 KGIKISQQIRTGTYGIN-WYAFDPGSPFGGYKNSGIGRENGPEGVEHFTQQKSVLLPMG 483 >5VBF-A nrPDB Length = 478 Score = 490 bits (1262), Expect = e-139, Method: Composition-based stats. Identities = 159/476 (33%), Positives = 239/476 (50%), Gaps = 8/476 (1%) Query: 11 PLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSG 70 PL R AD T+ +P T RV+ + +++ AVQ A AF W +S Sbjct: 6 PLRLYIDGRFHDADGRRTQPVVDPGTTRVLGELPHATAHDIDAAVQAAHRAFVTWRHESP 65 Query: 71 MERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGE 130 + R +L AA + RER + I ++ GK + EA ++ + + LE++A G Sbjct: 66 LVRSDLLRRAAALARERAETIGRHITMDQGKPLREAIAEVVSAAEQLEWHAEEGRRTYGR 125 Query: 131 HIQLPGGSFGYT-RREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSA 189 + T REP+GVC WN+PF A K A ALA G +V K +P + Sbjct: 126 VVPARSPDVMQTVLREPIGVCAAFSPWNFPFSQAMHKIAAALASGCTLVLKGPEESPSAI 185 Query: 190 LLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGI 248 + LA+++ +AG+PPG N+V G + L + P V K+SFTGSVP G ++ ++A + Sbjct: 186 VALAQLFHDAGLPPGCLNIVWGVPGDVSKQLIEAPQVRKISFTGSVPVGKQLAALAASLM 245 Query: 249 KPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEV 308 K +T+ELGG +P+++ +D D+ A F GQVC + TR FVQ+ D+F Sbjct: 246 KRMTMELGGHAPVLVCADADVERAAAMLAAYKFRNAGQVCVSPTRFFVQRAAFDRFVCAY 305 Query: 309 VKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLK 368 + I++G L MGPL + ++ + FV A +GA++ GG Sbjct: 306 LDAVGTIRVGYGLDAGVTMGPLAHARRVDEIDAFVADATAKGAQIATGGMRLP------G 359 Query: 369 DGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDI 428 G+Y P V+ D + +E FGP++ I+ FD + L AN FGLA+ FT Sbjct: 360 PGHYFAPTVVLGPTRDTRLMNDEPFGPIVGIVPFDDLDDALAEANRLPFGLASYAFTTSA 419 Query: 429 QRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVC 484 + AHR+ L+AG IN++ + P E+PFGG K SGFG E G + Y K V Sbjct: 420 RNAHRISRALEAGMVNINHFGMGPAEIPFGGVKDSGFGSEGGMEAFDGYLVTKFVT 475 >4JZ6-A nrPDB Length = 500 Score = 487 bits (1255), Expect = e-138, Method: Composition-based stats. Identities = 159/488 (32%), Positives = 254/488 (52%), Gaps = 17/488 (3%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMER 73 + A ++ +D T + P + V+ + + A Q A+ AFK W ER Sbjct: 23 FINNAWIDSSD-QQTFERKHPVSSEVMTESANATVTDAIKAAQAAEEAFKTWKDVGPSER 81 Query: 74 CRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQ 133 R+LL+ A ++ + + + + G S A ++ S A LA + GE I Sbjct: 82 RRLLLKVADVMESKTPKFIEVMAMEVGASALWAGFNVHASANVFREAASLATQIQGETIP 141 Query: 134 LP-GGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLL 192 + T R+P+G + I WN +A+ A L CGN +VFK S F+P + L+ Sbjct: 142 TDKAETLSMTLRQPVGPILSIVPWNGTAVLAARAIAYPLVCGNTVVFKGSEFSPATHALI 201 Query: 193 AEIYSEAGVPPGLFNVVQGGA----ATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGI 248 + EAG+P G+ N + L ++ +++FTGS G I + +A+ + Sbjct: 202 TQCVQEAGLPAGVLNYLNSSPDRSPEIADALISAKEIRRINFTGSTRVGSIIAQKAAQHL 261 Query: 249 KPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEV 308 K LELGGKSPLI+ D D+N AVK A+ +FL QGQ+C + R+ V ++I D+F Sbjct: 262 KRCLLELGGKSPLIVLDDADINAAVKAAVFGSFLFQGQICMSTERLVVDEKIADEFVARF 321 Query: 309 VKQTQRIKIGDP-LLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKL 367 V++T+R+ +GDP L D +GP+++ ER+ G K A ++GAKV+CGG + Sbjct: 322 VEKTERLSVGDPCLTGDCIIGPMVSPNSGERINGLFKDAIDKGAKVVCGG---------M 372 Query: 368 KDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRD 427 G M +L + + DM EE FGP+ ++ EAE + AND+ +GL++GVF RD Sbjct: 373 AQGAVMPATILDHVKSDMRIYDEETFGPITVVIRCKGEAEAIRIANDSVYGLSSGVFGRD 432 Query: 428 IQRAHRVVAELQAGTCFINNYNV-SPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 486 I RA RV ++ G IN V + + P+GG K +G+GR +GR I+ +++LK + +E Sbjct: 433 INRALRVGMSIEYGCVHINGSTVQNEAQAPYGGTKNTGYGRFDGRAVIDEFTELKWLTIE 492 Query: 487 MGDVESAF 494 + + F Sbjct: 493 PFEQQYPF 500 >3RH9-A nrPDB Length = 506 Score = 487 bits (1253), Expect = e-138, Method: Composition-based stats. Identities = 152/483 (31%), Positives = 251/483 (51%), Gaps = 8/483 (1%) Query: 3 TGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAF 62 + ++ Y GG + A T + PATG VIA E++V AV+ ++A Sbjct: 4 IESPLLENLTGYIGGRWKDSA-GGATFDVYNPATGSVIAKVPSMPEEDVVAAVEAGQSAL 62 Query: 63 KIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAG 122 ++ + R + L + ++E +EI + C+ +GK EA+ ++D + +Y A Sbjct: 63 RLTNPWPIETRRKWLEDIRDGLKENREEIGRILCMEHGKPWKEAQGEVDYAAGFFDYCAK 122 Query: 123 LAASMAGEHIQ-LPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKP 181 +++ I P P+GV I WN+P + + K + ALA G V KP Sbjct: 123 HISALDSHTIPEKPKDCTWTVHYRPVGVTGLIVPWNFPIGMIAKKLSAALAAGCPSVIKP 182 Query: 182 SPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAAT-GQFLCQHPDVAKVSFTGSVPTGMKI 240 + TP++ + + + +P G+ N+V G A+ G+ LC+H DV +SFTGS G K+ Sbjct: 183 ASETPLTMIAFFSVMDKLDLPDGMVNLVMGKASVIGKVLCEHKDVPMLSFTGSTEVGRKL 242 Query: 241 MEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEI 300 + +A+ +K + LELGG +P I+F D D+ A + F GQ C R+FV +++ Sbjct: 243 IVDTAEQVKKLALELGGNAPFIVFDDADLEAAADNLIANKFRGGGQTCVCANRIFVHEKV 302 Query: 301 LDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY 360 D F +++ ++ ++ +GD + + +GPLIN+ ++V ++ A ++GA ++ G Sbjct: 303 ADAFGQKLAERVNKMTVGDGMNDGIDIGPLINKQGFDKVKRHLQDALDKGASLVAG---- 358 Query: 361 VPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA 420 + +L DG + P V+ +M C +EE FGP++ + F TE EV++ NDT FGLA Sbjct: 359 -KQPAELGDGLFFPPTVVQGVDREMCCYQEETFGPLVPMALFRTEEEVIDAGNDTEFGLA 417 Query: 421 AGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQL 480 + VFT D +RA RV A L+ G N E PFGG K SG GRE G + + + Sbjct: 418 SYVFTADAERAQRVAAGLRFGHVGWNTGTGPTPEAPFGGMKASGIGREGGLEGLFEFVEA 477 Query: 481 KTV 483 +TV Sbjct: 478 QTV 480 >3RHD-A nrPDB Length = 486 Score = 484 bits (1246), Expect = e-137, Method: Composition-based stats. Identities = 149/480 (31%), Positives = 241/480 (50%), Gaps = 24/480 (5%) Query: 12 LNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGM 71 + + G + D P + VI +E A+ A+ ++ Sbjct: 1 VMFIDGKWINRED----MDVINPYSLEVIKKIPALSREEAKEAIDTAEKYKEVMKNLPIT 56 Query: 72 ERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEH 131 +R IL+ A+ I+E+++E+A + I+ GK I +AR++++ S + A E Sbjct: 57 KRYNILMNIAKQIKEKKEELAKILAIDAGKPIKQARVEVERSIGTFKLAAFYVKEHRDEV 116 Query: 132 IQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALL 191 I +TRREP+G+ I +N+P +++ K APA+A GN +V PS P+ + Sbjct: 117 IPSD-DRLIFTRREPVGIVGAITPFNFPLNLSAHKIAPAIATGNVIVHHPSSKAPLVCIE 175 Query: 192 LAEIYSEA----GVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK 246 LA+I A VP G++N++ G G G + + V +SFTGS G I + + Sbjct: 176 LAKIIENALKKYNVPLGVYNLLTGAGEVVGDEIVVNEKVNMISFTGSSKVGELITKKAG- 234 Query: 247 GIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTE 306 K + LELGG +P I+ D D+N AV + +F+ GQVC + + V + I DKF E Sbjct: 235 -FKKIALELGGVNPNIVLKDADLNKAVNALIKGSFIYAGQVCISVGMILVDESIADKFIE 293 Query: 307 EVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPK 366 V + + + +G+PL E T +GPLI+ H E V V+ A ++G K+L GG Sbjct: 294 MFVNKAKVLNVGNPLDEKTDVGPLISVEHAEWVEKVVEKAIDEGGKLLLGGK-------- 345 Query: 367 LKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTR 426 +D P +L D K E F PV+ I+ E E+++ AN T +GL + +FT Sbjct: 346 -RDKALFYPTILE-VDRDNILCKTETFAPVIPIIR-TNEEEMIDIANSTEYGLHSAIFTN 402 Query: 427 DIQRAHRVVAELQAGTCFINNYNVSPVE-LPFGGYKKSGFGRENGRVTIEYYSQLKTVCV 485 DI ++ + L+ G IN+ ++ + +PFGG KKSG GRE + +E S +KT+ + Sbjct: 403 DINKSLKFAENLEFGGVVINDSSLFRQDNMPFGGVKKSGLGREGVKYAMEEMSNIKTIII 462 >2JG7-A nrPDB Length = 510 Score = 482 bits (1241), Expect = e-136, Method: Composition-based stats. Identities = 126/483 (26%), Positives = 225/483 (46%), Gaps = 17/483 (3%) Query: 15 RGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERC 74 G+ + ++ PA IA T + E VQ + A+K+W+ +R Sbjct: 26 YNGSW---GGSGEVITSYCPANNEPIARVTQATLAEYEETVQKTREAWKMWADIPAPKRG 82 Query: 75 RILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQL 134 I+ + +R++ + ++ + GK E ++ +Y GL+ + G + Sbjct: 83 EIVRQIGDALRKKIKVLGSLVSLEMGKIYVEGVGEVQEYVDVCDYAVGLSRMIGGPVLPS 142 Query: 135 PGGSFGYTRRE-PLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSAL--- 190 + P+G+ I A+N+P + W +A AL CGN ++K +P TP++++ Sbjct: 143 ERPGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIALTCGNVCLWKGAPTTPLTSVAVT 202 Query: 191 -LLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIK 249 ++AE+ + +P + ++ GGA G + + V +SFTGS G + M + Sbjct: 203 KIVAEVLEQNNLPGAICSMTCGGADIGTAMAKDERVDLLSFTGSTHVGKMVAMMVQERFG 262 Query: 250 PVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVV 309 LELGG + +I+F D D+N V A+ A+ T GQ C R+ + + + D E + Sbjct: 263 RKLLELGGNNAIIVFEDADLNLVVPSAVFASVGTAGQRCTTTRRLMLHESVHDAVVERIA 322 Query: 310 KQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKD 369 K ++++IGDP T GPL + +++ L ++ AK+QG ++CGG + + Sbjct: 323 KAYKQVRIGDPWDPSTLYGPLHTKQAVDQYLAAIEQAKQQGGTLVCGGKVMD------RP 376 Query: 370 GYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQ 429 G Y+ P ++T D V E F P++ +L F TE E N+ GL++ +FT+D+ Sbjct: 377 GNYVEPTIITGLAHDAPIVHTETFVPILYVLKFKTEEEAFAWNNEVQQGLSSSIFTKDLG 436 Query: 430 RAHRVV--AELQAGTCFINNYNVSP-VELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 486 R R + G +N + FGG K +G GRE+G + + Y + T + Sbjct: 437 RVFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDSWKQYMRRSTCTIN 496 Query: 487 MGD 489 Sbjct: 497 YSK 499 >4YWE-A nrPDB Length = 487 Score = 476 bits (1226), Expect = e-135, Method: Composition-based stats. Identities = 171/482 (35%), Positives = 250/482 (51%), Gaps = 8/482 (1%) Query: 10 QPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFK-IWSQK 68 + ++ G PA T +P+ G+ AT ++ AV A+ AF W Sbjct: 11 EAKHFIAGEWTLPAQL-ETIPVVDPSDGQPFATIARGTAPDIERAVAAARDAFAGPWGAA 69 Query: 69 SGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMA 128 S ER R+L+ + + + +E+A +E + GK + +AR D + E+YAG A + Sbjct: 70 SAAERGRVLMRLSARVTDSIEELAAIEARDTGKPLKQARADAAALARYFEFYAGAADKLH 129 Query: 129 GEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVS 188 GE + G T REP GV I WNYP QI ALA GNA V KP+ +S Sbjct: 130 GETLPYQAGYTVLTVREPHGVTGHIVPWNYPMQIFGRSVGAALAAGNACVVKPAEDACLS 189 Query: 189 ALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKG 247 L +AE+ +EAG+P G N+V G G G L +HP + +SFTGS TG + +M+A+ Sbjct: 190 VLRVAELAAEAGLPAGALNIVTGYGHEAGAALARHPGIDHISFTGSPATGKLVTQMAAEN 249 Query: 248 IKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEE 307 PVTLELGGKSP I+F+D D++ A+ + A GQ C G+RV +++ + + E Sbjct: 250 HVPVTLELGGKSPQIVFADADLDAALPVLVSAIVQNGGQTCSAGSRVLIERAVYEPLVER 309 Query: 308 VVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKL 367 + +++G P D GPLIN +RV F+ A+ G + G + Sbjct: 310 LATAFNGLRVG-PSRADLDCGPLINAKQQQRVWDFLSDAQHDGIPMAAHGQVVAD---AP 365 Query: 368 KDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRD 427 + G+Y P +L + +EE+FGPV++ + F E E + AN T +GL AG++TRD Sbjct: 366 ESGFYQAPALLRDVPPSHRLAQEEVFGPVLAAMRFVDEDEAVALANGTPYGLVAGIWTRD 425 Query: 428 IQRAHRVVAELQAGTCFINNYNV-SPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 486 R R+ L+AG FINNY VELPFGG SG GRE G + ++ LKT+ + Sbjct: 426 GARQMRLARRLRAGQVFINNYGAGGGVELPFGGVGHSGHGREKGFEALYGFTALKTIAIR 485 Query: 487 MG 488 G Sbjct: 486 HG 487 >4X0T-A nrPDB Length = 513 Score = 475 bits (1224), Expect = e-134, Method: Composition-based stats. Identities = 121/483 (25%), Positives = 217/483 (44%), Gaps = 17/483 (3%) Query: 15 RGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERC 74 G+ + PA IA + + V+ A+ A+KIW+ +R Sbjct: 29 YNGSW---GGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRG 85 Query: 75 RILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQL 134 I+ + +RE+ + ++ + GK + E ++ +Y GL+ + G + Sbjct: 86 EIVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQEYVDICDYAVGLSRMIGGPILPS 145 Query: 135 PGGSFGYTRRE-PLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSAL--- 190 + P+G+ I A+N+P + W +A A+ CGN ++K +P T + ++ Sbjct: 146 ERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVT 205 Query: 191 -LLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIK 249 ++A++ + +P + ++ GGA G + + V +SFTGS G ++ M + Sbjct: 206 KIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFG 265 Query: 250 PVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVV 309 LELGG + +I F D D++ V AL A T GQ C R+F+ + I D+ + Sbjct: 266 RSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLK 325 Query: 310 KQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKD 369 K +I++G+P + GPL + + LG V+ AK++G V+ GG + + Sbjct: 326 KAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMD------RP 379 Query: 370 GYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQ 429 G Y+ P ++T D + E F P++ + F E EV N+ GL++ +FT+D+ Sbjct: 380 GNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLG 439 Query: 430 RAHRVV--AELQAGTCFINNYNVSP-VELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 486 R R + G +N + FGG K +G GRE+G + Y + T + Sbjct: 440 RIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTIN 499 Query: 487 MGD 489 Sbjct: 500 YSK 502 >4DNG-A nrPDB Length = 485 Score = 475 bits (1224), Expect = e-134, Method: Composition-based stats. Identities = 129/481 (26%), Positives = 238/481 (49%), Gaps = 15/481 (3%) Query: 11 PLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSG 70 ++ G ++ TE P VI T + + K++ A A+ A K W++ + Sbjct: 7 NKSFINGKW-TGGESGRTEDILNPYDQSVITTASLATGKQLEDAFDIAQKAQKEWAKSTT 65 Query: 71 MERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAG- 129 +R +L +A + E D+I M G +I ++ ++++ + L+ + G Sbjct: 66 EDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKSTIELEQTIAILDEAMTYTGELGGV 125 Query: 130 EHIQLP-GGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVS 188 + + G R PLGV I +N+P ++ APA+A GN++V KP T +S Sbjct: 126 KEVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLSMRSIAPAIALGNSVVHKPDIQTAIS 185 Query: 189 A-LLLAEIYSEAGVPPGLFNVVQGG-AATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK 246 ++A+ + AG+P G+ NV+ G + +P +SFTGS G I E++ + Sbjct: 186 GGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGMLTNPIPRLISFTGSTAVGRHIGEIAGR 245 Query: 247 GIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTE 306 K + LELGG +P + SD D++ AV A+ F+ QGQ+C R+ V +++ D+F E Sbjct: 246 AFKRMALELGGNNPFAVLSDADVDRAVDAAIFGKFIHQGQICMIINRIIVHQDVYDEFVE 305 Query: 307 EVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPK 366 + + +++ GD T +GPLIN +E+ L ++ AK G ++ G Sbjct: 306 KFTARVKQLPYGDQTDPKTVVGPLINERQIEKALEIIEQAKTDGIELAVEGK-------- 357 Query: 367 LKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTR 426 + G + P V ++ + E+F P+ +I+ ++ E ++ ANDT +GL++ VFT Sbjct: 358 -RVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKAGSDQEAIDMANDTEYGLSSAVFTS 416 Query: 427 DIQRAHRVVAELQAGTCFINNYNVSP-VELPFGGYKKSGFGRENGRVTIEYYSQLKTVCV 485 D+++ + ++ +G +N+ +V+ + FGG K SG GR +E ++ K + + Sbjct: 417 DLEKGEKFALQIDSGMTHVNDQSVNDSPNIAFGGNKASGVGRFGNPWVVEEFTVTKWISI 476 Query: 486 E 486 + Sbjct: 477 Q 477 >2QE0-A nrPDB Length = 475 Score = 475 bits (1223), Expect = e-134, Method: Composition-based stats. Identities = 146/486 (30%), Positives = 233/486 (47%), Gaps = 23/486 (4%) Query: 10 QPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKS 69 Q NY G + K +EPA+G + + +EV+ +AK A W S Sbjct: 4 QYKNYVNGEWKLSENE---IKIYEPASGAELGSVPAMSTEEVDYVYASAKKAQPAWRALS 60 Query: 70 GMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAG 129 +ER L + A I+ +++I + K A ++ + + + Y A M G Sbjct: 61 YIERAAYLHKVADILMRDKEKIGAILSKEVAKGYKSAVSEVVRTAEIINYAAEEGLRMEG 120 Query: 130 EHIQ------LPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSP 183 E ++ RREP+G+ + I +NYP +A K APAL GN + FKP Sbjct: 121 EVLEGGSFEAASKKKIAVVRREPVGLVLAISPFNYPVNLAGSKIAPALIAGNVIAFKPPT 180 Query: 184 FTPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIME 242 +S LLLAE ++EAG+P G+FN + G G+ G ++ +H V ++FTGS G +I + Sbjct: 181 QGSISGLLLAEAFAEAGLPAGVFNTITGRGSEIGDYIVEHQAVNFINFTGSTGIGERIGK 240 Query: 243 MSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILD 302 M+ ++P+ L LGGK I+ D D+ K + F GQ C RV V + + D Sbjct: 241 MAG--MRPIMLALGGKDSAIVLEDADLELTAKNIIAGAFGYSGQRCTAVKRVLVMESVAD 298 Query: 303 KFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVP 362 + E++ ++ + IG+P D + PLI+ + V G + A ++GA L Sbjct: 299 ELVEKIREKVLALTIGNPED-DADITPLIDTKSADYVEGLINDANDKGATALT------- 350 Query: 363 EDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAG 422 ++G + P + DM EE FGPV+ I+ + E +E +N + +GL A Sbjct: 351 --EIKREGNLICPILFDKVTTDMRLAWEEPFGPVLPIIRVTSVEEAIEISNKSEYGLQAS 408 Query: 423 VFTRDIQRAHRVVAELQAGTCFINNYN-VSPVELPFGGYKKSGFGRENGRVTIEYYSQLK 481 +FT D RA + +L+ GT INN PF G KKSG G + + +IE + +K Sbjct: 409 IFTNDFPRAFGIAEQLEVGTVHINNKTQRGTDNFPFLGAKKSGAGIQGVKYSIEAMTTVK 468 Query: 482 TVCVEM 487 +V ++ Sbjct: 469 SVVFDI 474 >6FK3-A nrPDB Length = 536 Score = 474 bits (1221), Expect = e-134, Method: Composition-based stats. Identities = 150/492 (30%), Positives = 237/492 (48%), Gaps = 20/492 (4%) Query: 13 NYRGGARVEPADASGTEKAFEPATGR-VIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGM 71 + GG V + P+ V+A F + + V A A+ AF WS+ Sbjct: 22 HLVGGEEVL---EGPLLERRNPSDREDVVARFPEADKDLVRKAALKAREAFAEWSRTPAP 78 Query: 72 ERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEH 131 R ++L +I+ + + + GK+ EA D+ + ++A + G+ Sbjct: 79 IRGQVLFNLVKILEREKPTLTRLMVREVGKTPKEAAGDVQEAIDTALFFASEGRRLYGQT 138 Query: 132 IQLPG-GSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSAL 190 + +T R PLGV I A N+P + SWK PA+ GN +V+KPS P + Sbjct: 139 VPSEMRDKELFTFRRPLGVVGIITAGNFPIAVPSWKLIPAVLTGNTVVWKPSEDAPTLSF 198 Query: 191 LLAEIYSEAGVPPGLFNVVQGGA--ATGQFLCQHPD---VAKVSFTGSVPTGMKIMEMSA 245 + A+++ EAG+PPG+ NVV GG +TGQ++ + D K +FTGS G I E++ Sbjct: 199 VFAKLFEEAGLPPGVLNVVFGGGKGSTGQWMVELMDEGLFQKFAFTGSTQVGRWIGEVAG 258 Query: 246 KGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFT 305 + + TLELGGK+PL++ D D++ AV+GA + F T GQ C + + V I ++F Sbjct: 259 RNLIRPTLELGGKNPLVVMRDADLDLAVEGAWWSAFATGGQRCTSAGNILVDAPIYEEFK 318 Query: 306 EEVVKQTQRIKIGDPLL-EDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPED 364 +++ + +G+PLL + GP IN R +V + +GA++L G E+ Sbjct: 319 RRFLERVEATLVGNPLLHPEVTYGPFINERFFARWQEHYRVGEAEGARLLFGRGRITREN 378 Query: 365 PKLK------DGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFG 418 P + G Y P V R EE+FGP ++++ D E + AN T +G Sbjct: 379 PYPRFLGDPEAGLYGWPTVWE-VRPGTRLFTEEVFGPTINLVKVDGIEEAIAVANSTPYG 437 Query: 419 LAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSP-VELPFGGYKKSGF-GRENGRVTIEY 476 L++ ++T A+ ++AG INN V LPFGG K SG GRE+G +E Sbjct: 438 LSSAIYTNHRHWAYLFKVGIRAGMTSINNATVGAEAHLPFGGVKASGNGGRESGIWVLEE 497 Query: 477 YSQLKTVCVEMG 488 Y+ V E Sbjct: 498 YTYWHAVNEEYS 509 >3VZ3-A nrPDB Length = 457 Score = 473 bits (1219), Expect = e-134, Method: Composition-based stats. Identities = 139/456 (30%), Positives = 212/456 (46%), Gaps = 6/456 (1%) Query: 31 AFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDE 90 P TG + F E++ + A+ AF+ + + S +R + L AA I+ + Sbjct: 8 TINPTTGEICQRFKALTPAEIDAKLAKAQEAFQAYRRTSFSQRRQWLENAAAILERDTSK 67 Query: 91 IATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVC 150 A + GK+ A + + S YYA + Y +PLG+ Sbjct: 68 FAEIMTTEMGKTHQSAIAEAEKSALVCRYYAEHGEQFLANEYTETQATESYVCYQPLGIL 127 Query: 151 VGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQ 210 + + WN+PF +APAL GN V K + P AL + I AG P G+F + Sbjct: 128 LAVMPWNFPFWQVFRFAAPALMAGNVAVLKHASNVPQCALAVEAILEAAGFPEGVFQTLL 187 Query: 211 GGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMN 270 GA+ + + + P V + TGS P G + ++ + IKP LELGG P ++F D++ Sbjct: 188 IGASQVEQVIKDPRVKAATLTGSEPAGASLASLAGQEIKPTLLELGGSDPFVVFPSADLD 247 Query: 271 NAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPL 330 AV+ +A + GQ R + + I +F E++ + +KIGDP+ +T +GPL Sbjct: 248 EAVEVGTVARTMNNGQSAIAAKRFILHEAIAAEFLEKLHLKFASLKIGDPMAPETDIGPL 307 Query: 331 INRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKE 390 L+ + V A GAK+L GG P + GY+ P +LT ++E Sbjct: 308 ATEGILQDISRQVDQAVAAGAKILLGGR------PLDRAGYFYPPTILTEIPPGAKILQE 361 Query: 391 EIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNV 450 E+F PV + + + + AND FGL A +T D R + EL AG FIN Sbjct: 362 ELFAPVAMVFTVKDLDQAIALANDIPFGLGASAWTNDPAEQQRFIQELDAGAVFINGMVK 421 Query: 451 SPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 486 S LPFGG K+SG+GRE G I + KTV ++ Sbjct: 422 SDPRLPFGGTKRSGYGRELGLAGIRTFVNAKTVWLK 457 >6MVR-A nrPDB Length = 767 Score = 471 bits (1213), Expect = e-133, Method: Composition-based stats. Identities = 168/473 (35%), Positives = 263/473 (55%), Gaps = 27/473 (5%) Query: 8 VSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQ 67 ++ GGA P D T PATG+ +A + + + +V+ AV+ A+ A W++ Sbjct: 30 KGDFGHFIGGAWTAPGDLFAT---VNPATGQTLAQVSQATQADVDAAVKAARKAQPAWAK 86 Query: 68 KSGMERCRILLEAARIIREREDEIATMECINNGKSIFEAR-LDIDISWQCLEYYAGLAAS 126 G R R+L AR++++ A +E ++NGK I EAR +D+ ++ + ++AG A Sbjct: 87 -DGAARARVLYALARLLQKHARLFAVLETLDNGKPIREARDIDVPLAQRHFYHHAGYAQL 145 Query: 127 MAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTP 186 M E R PLGVC + WN+P + +WK APALA GN +V KP+ +TP Sbjct: 146 MGTEMPD----------RAPLGVCGQVIPWNFPLLMLAWKIAPALAMGNTVVLKPAEWTP 195 Query: 187 VSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK 246 ++ALL A+I +AGVP G+ N+V G A G+ + V KV+FTGS G +I E +A Sbjct: 196 LTALLFADICGQAGVPAGVVNIVTGDGAVGEMIVT-AQVDKVAFTGSTAVGRRIREATAG 254 Query: 247 GIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTE 306 K ++LELGGK P ++ D D+++AV+G + A + QGQVCC G+R+ VQ+ I D F Sbjct: 255 TGKALSLELGGKGPYVVCDDADIDSAVEGLVDAIWFNQGQVCCAGSRLLVQEGIADVFHA 314 Query: 307 EVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPK 366 ++ + ++IGDPL + +G +++ L RV V G++Y P Sbjct: 315 KLRARMDSLRIGDPLDKCIDIGAMVHPDQLARVRDMVAAN--------TDGEVYQTAVPA 366 Query: 367 LKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTR 426 G Y P +++ +++EIFGPV+ +F T AE +E AN+T +GLAA V++ Sbjct: 367 ---GCYYPPTLISGLAPASPLMQQEIFGPVLVSTTFRTPAEAVEIANNTAYGLAASVWSE 423 Query: 427 DIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQ 479 ++ A + +L AG +IN N+ PFGG ++SGFGRE G + Y++ Sbjct: 424 NVNLALDLAPKLVAGIVWINGTNMMDAAAPFGGVRESGFGREGGWEGLAGYTR 476 Score = 122 bits (307), Expect = 3e-28, Method: Composition-based stats. Identities = 58/238 (24%), Positives = 96/238 (40%), Gaps = 9/238 (3%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMER 73 Y GG + P D + + P G+++ + S K++ AV+ AA WS+ +G R Sbjct: 506 YIGGKQTRP-DGGYSRAVYGP-KGKLLGHASLSNRKDLRNAVEAMNAA-SGWSRTTGHLR 562 Query: 74 CRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQ 133 +IL + R DE A GK + + ++ S L A A G+ Sbjct: 563 AQILYFIGENLSARADEFANRIKDMTGK---DGKAEVAASIDRLFSAAAWADKYDGQVKG 619 Query: 134 LPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLA 193 +P +EP+G + P APA+A GN + S P++A Sbjct: 620 VPLRGVALAMKEPVGKIGILCPDAAPLLGLVSLMAPAIAMGNRVTLAASEAFPLAATDFY 679 Query: 194 EIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKP 250 ++ + VP G+ N++ G A + + +H D+ V G I SA +K Sbjct: 680 QVLDTSDVPAGVVNILTGAHADLAEPMARHLDLDAVW--GLSGHAQVIEAASAGNLKR 735 >3EFV-A nrPDB Length = 462 Score = 468 bits (1204), Expect = e-132, Method: Composition-based stats. Identities = 144/454 (31%), Positives = 220/454 (48%), Gaps = 6/454 (1%) Query: 31 AFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDE 90 + PATG+ +A + +E+ A+ A + FK W S +R + L + + +R +E Sbjct: 11 SVNPATGQTLAAMPWANAQEIEHALSLAASGFKKWKMTSVAQRAQTLRDIGQALRAHAEE 70 Query: 91 IATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVC 150 +A GK I +AR ++ S ++YA +M L PLGV Sbjct: 71 MAQCITREMGKPIKQARAEVTKSAALCDWYAEHGPAMLNPEPTLVENQQAVIEYRPLGVI 130 Query: 151 VGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQ 210 + I WN+P + P L GN+ + K +P A ++A I +EAG P G++ V Sbjct: 131 LAIMPWNFPLWQVLRGAVPILLAGNSYLLKHAPNVTGCAQMIARILAEAGTPAGVYGWVN 190 Query: 211 GGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMN 270 + P +A V+ TGSV G I + +K LELGG P I+ +D D+ Sbjct: 191 ANNEGVSQMINDPRIAAVTVTGSVRAGAAIGAQAGAALKKCVLELGGSDPFIVLNDADLE 250 Query: 271 NAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPL 330 AVK A+ + GQVC R V++ I FT+ V +K+GDPL+E+ +GP+ Sbjct: 251 LAVKAAVAGRYQNTGQVCAAAKRFIVEEGIAQAFTDRFVAAAAALKMGDPLVEENDLGPM 310 Query: 331 INRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKE 390 + + V+ + +GA++L GG+ +G Y VL + DMT ++ Sbjct: 311 ARFDLRDELHQQVQASVAEGARLLLGGEKIA------GEGNYYAATVLADVTPDMTAFRQ 364 Query: 391 EIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNV 450 E+FGPV +I A L AND+ FGL+A +FT D A + A L+ G FIN Y+ Sbjct: 365 ELFGPVAAITVAKDAAHALALANDSEFGLSATIFTADDTLAAEMAARLECGGVFINGYSA 424 Query: 451 SPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVC 484 S + FGG KKSGFGRE + + ++TV Sbjct: 425 SDARVAFGGVKKSGFGRELSHFGLHEFCNVQTVW 458 >3ROS-A nrPDB Length = 484 Score = 467 bits (1202), Expect = e-132, Method: Composition-based stats. Identities = 131/456 (28%), Positives = 207/456 (45%), Gaps = 8/456 (1%) Query: 29 EKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIRERE 88 ++ P T A++ K+++ A+ A A +K W + R IL + A ++E E Sbjct: 6 YQSVNPYTNEAFASYDNPTSKQIDEAINLAHALYKKWRHEEPASRAEILHDIANALKEHE 65 Query: 89 DEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLG 148 DE+A M + GK + E++ ++++ YYA M Y ++ G Sbjct: 66 DELAKMMTLEMGKLLSESKEEVELCVSICNYYADHGPEMLKPTKLNSDLGNAYYLKQSTG 125 Query: 149 VCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPG-LFN 207 V + WN+P AP GN ++ K + P SA L A+I AG P G L N Sbjct: 126 VIMACEPWNFPLYQVIRVFAPNFIVGNPILLKHAHNVPGSAALTAKIIKRAGAPEGSLIN 185 Query: 208 VVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDC 267 + + P + V+ TGS G + E + K +K T+ELGG I+ D Sbjct: 186 LYPSYDQLAD-IIADPRIQGVALTGSERGGSAVAEAAGKNLKKSTMELGGNDAFIVLDDA 244 Query: 268 DMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRM 327 D A GQVC + R+ V+K D+ E+ +K GDPL DT + Sbjct: 245 DPQVLRNVLNDARTYNDGQVCTSSKRIIVEKSRYDEVLHELKNVFSNLKAGDPLEADTTL 304 Query: 328 GPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTC 387 P+ + E++ VK A + GAKV G + RP +LT+ D Sbjct: 305 PPMNSEKAKEKLEAQVKEAIDAGAKVFY------QYPEIDSKGAFFRPTILTDIAKDNPV 358 Query: 388 VKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN 447 +E+FGP+ + + + ++ AND+++GL + V DI RA +V A+++ G IN Sbjct: 359 FDKEVFGPIAEVFVVEDDNAAIQLANDSSYGLGSSVIGSDIDRAKKVSAQIETGMTVING 418 Query: 448 YNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTV 483 ++ ELPFGG KKSG+GRE + + + V Sbjct: 419 RWITSGELPFGGIKKSGYGRELSGLGLMAFVNEHLV 454 >3R64-A nrPDB Length = 508 Score = 465 bits (1197), Expect = e-131, Method: Composition-based stats. Identities = 159/489 (32%), Positives = 246/489 (50%), Gaps = 16/489 (3%) Query: 12 LNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGM 71 + GG VE ++ P VIA + +V+ A + AK A W+ Sbjct: 14 KHLIGGQWVEG-NSDRISTNINPYDDSVIAESKQASIADVDAAYEAAKKAQAEWAATPAA 72 Query: 72 ERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEH 131 ER I+ AA ++ E +EI +G + +A L+I ++ + A + G Sbjct: 73 ERSAIIYRAAELLEEHREEIVEWLIKESGSTRSKANLEITLAGNITKESASFPGRVHGRI 132 Query: 132 IQL-PGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSA- 189 G R GV I WN+P ++ APALA GNA+V KP+ TPV+ Sbjct: 133 SPSNTPGKENRVYRVAKGVVGVISPWNFPLNLSIRSVAPALAVGNAVVIKPASDTPVTGG 192 Query: 190 LLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMS--AK 246 ++ A I+ EAGVP G+ + V G G+ G H +SFTGS P G ++ E++ Sbjct: 193 VIPARIFEEAGVPAGVISTVAGAGSEIGDHFVTHAVPKLISFTGSTPVGRRVGELAINGG 252 Query: 247 GIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTE 306 +K V LELGG +P ++ +D D++ A + A + FL QGQ+C + RV V + D+F E Sbjct: 253 PMKTVALELGGNAPFVVLADADIDAAAQAAAVGAFLHQGQICMSINRVIVDAAVHDEFLE 312 Query: 307 EVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPK 366 + V+ + I GDP E T +GP+IN L + +++AK++GA V G I Sbjct: 313 KFVEAVKNIPTGDPSAEGTLVGPVINDSQLSGLKEKIELAKKEGATVQVEGPI------- 365 Query: 367 LKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTR 426 +G + P V ++ DM +EEIFGP++S+L D EA E AN + FGL+A V+++ Sbjct: 366 --EGRLVHPHVFSDVTSDMEIAREEIFGPLISVLKADDEAHAAELANASDFGLSAAVWSK 423 Query: 427 DIQRAHRVVAELQAGTCFINNYNVSP-VELPFGGYKKSGFGRENGRVTIEYYSQLKTVCV 485 DI RA + ++ +G IN+ V+ + FGG K SG GR NG IE ++ + + + Sbjct: 424 DIDRAAQFALQIDSGMVHINDLTVNDEPHVMFGGSKNSGLGRFNGDWAIEEFTTDRWIGI 483 Query: 486 EMGDVESAF 494 + F Sbjct: 484 KRSAENLYF 492 >3VZ0-A nrPDB Length = 459 Score = 465 bits (1197), Expect = e-131, Method: Composition-based stats. Identities = 134/458 (29%), Positives = 215/458 (46%), Gaps = 7/458 (1%) Query: 29 EKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI-WSQKSGMERCRILLEAARIIRER 87 + P T V +F ++ A+ +K W +S +R I+ AA ++R Sbjct: 7 YQTLNPTTETVERSFDLHTPAQMKDITDRAEHVWKTDWKLRSIAQRKEIVSRAADLLRRD 66 Query: 88 EDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPL 147 A++ GK++ +A +ID++ L +YA A +PL Sbjct: 67 RQHHASLIATEMGKALPDALEEIDVTADILSFYANGAEEFLAPTPLKVKTGQAKIINQPL 126 Query: 148 GVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFN 207 G+ I WN+P+ + + P L GN ++ K +P P AL +++ +AG P G + Sbjct: 127 GIIYCIEPWNFPYYQLARVAGPNLMAGNVVIAKHAPNVPQCALAFEKLFHDAGAPVGAYA 186 Query: 208 VVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDC 267 + L + + V+ TGS G + + +K T+ELGG I+ D Sbjct: 187 NIFLDNDQSAELIKDERIRGVALTGSERAGQAVAAQAGAALKKDTMELGGSDAFIVLDDA 246 Query: 268 DMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRM 327 D++ AVK A+ F GQVC R+ V +++ D F + + R +IG+PL DT Sbjct: 247 DLDLAVKWAVWGRFANNGQVCTAAKRMIVHEKVYDAFLDGLKTAITRFRIGNPLDRDTTH 306 Query: 328 GPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTC 387 GP+ + +E L A + GA ++ GG + G++M P +LT+ D Sbjct: 307 GPMSSLRAMELALDQTAEAVKGGATLVAGGKRMD------RKGFFMEPTILTDVSKDNPV 360 Query: 388 VKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN 447 +EIFGPV + +E ++ AND+ +GL VF+RDI RA +V +++ G FIN Sbjct: 361 FYQEIFGPVAVVHKVASEQAAIDLANDSPYGLGGAVFSRDIARAEKVAEQVETGMVFINT 420 Query: 448 YNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCV 485 + ELPFGG K SGFGRE + IE + K V + Sbjct: 421 ATAAAPELPFGGIKNSGFGRELSFLGIEEFINRKLVRI 458 >4PXN-A nrPDB Length = 525 Score = 464 bits (1195), Expect = e-131, Method: Composition-based stats. Identities = 126/481 (26%), Positives = 213/481 (44%), Gaps = 18/481 (3%) Query: 17 GARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRI 76 GA + T + P +VIA + + ++ A K W +R I Sbjct: 44 GAW---GGSGPTVTSTSPTNNQVIAEVVEASVHDYEEGMRACFDAAKTWMAIPAPKRGEI 100 Query: 77 LLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQL-P 135 + + +R + + + + GK + E ++ +Y GL+ + G I Sbjct: 101 VRQIGDALRAKLHHLGRLVSLEMGKILPEGIGEVQEIIDMCDYAVGLSRQLNGSIIPSER 160 Query: 136 GGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSAL----L 191 PLGV I A+N+P + W + AL CGN +V+K +P TP+ + + Sbjct: 161 PNHMMMEVWNPLGVVGVITAFNFPCAVLGWNACIALVCGNCVVWKGAPTTPLITIAMTKI 220 Query: 192 LAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPV 251 +A + + +P +F GG GQ + + VSFTGS G+ + + + Sbjct: 221 VASVLEKNNLPGAIFTSFCGGTEIGQAIALDIRIPLVSFTGSTRAGLMVQQQVSARFGKC 280 Query: 252 TLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQ 311 LEL G + +I+ D D+ AV+ L A T GQ C R+ + + I F +++V+ Sbjct: 281 LLELSGNNAIIVMDDADIQLAVRSVLFAAVGTAGQRCTTCRRLILHENIYQTFLDQLVEV 340 Query: 312 TQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGY 371 ++++IGDPL + T +GPL E L ++ K QG K+L GG E G Sbjct: 341 YKQVRIGDPLEKGTLLGPLHTPASKENFLKGIQTIKSQGGKILFGGSAIESE------GN 394 Query: 372 YMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRA 431 +++P ++ VKEE+FGPV+ ++ F T E +E N GL++ +FT+ Sbjct: 395 FVQPTIVE-ITPSAPVVKEELFGPVLYVMKFQTLKEAIEINNSVPQGLSSSIFTKRPDII 453 Query: 432 HRVVAE--LQAGTCFIN-NYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMG 488 + + G +N N + + FGG K +G GRE G + + Y + T + G Sbjct: 454 FKWLGPHGSDCGIVNVNIPTNGAEIGGAFGGEKATGGGREAGSDSWKQYMRRATCTINYG 513 Query: 489 D 489 Sbjct: 514 S 514 >5UR2-A nrPDB Length = 984 Score = 463 bits (1191), Expect = e-130, Method: Composition-based stats. Identities = 125/475 (26%), Positives = 219/475 (46%), Gaps = 20/475 (4%) Query: 24 DASGTEKAFEPA-TGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAAR 82 + P+ + +++ + ++ A+Q A+ A+K W +R ++ + A Sbjct: 507 QSGKIFDRVNPSQSDQIVGKIQMATTEQAEQAMQAAQTAYKTWKNVPCEQRAALVDKLAD 566 Query: 83 IIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGE-HIQLPGGSFGY 141 I+ ++ + + GK EA DI + YYA + + G + Sbjct: 567 IMTRDRFKLIATQVLEVGKPWAEADGDIGEAIDFCRYYARHMRELQKPLRVGGLPGELSH 626 Query: 142 TRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGV 201 + GV I WN+P I + A GN +V KP+ + V A L ++ EAG Sbjct: 627 YIYKSRGVTAVIAPWNFPLAILAGMVTAAAVAGNTVVMKPAEQSTVVAWGLMKMIQEAGF 686 Query: 202 PPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSA------KGIKPVTLE 254 P G+ N + G G G+++ H ++FTGS G+ IM +A + +K +E Sbjct: 687 PQGVINFLPGYGEEVGEYIVNHKYTTTIAFTGSKAVGLHIMNRAAVVQPGQQHVKRCIIE 746 Query: 255 LGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQR 314 +GGK+ +II +D D++ AV G + + F GQ C +RV V E+ D+F + +V+ + Sbjct: 747 MGGKNAVIIDNDADLDEAVDGVIYSAFGFSGQKCSAASRVIVLDEVYDRFVDRLVETAKS 806 Query: 315 IKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMR 374 I+I MGP++++ +R+LG + A E+ K+L G + G++ Sbjct: 807 IEIHPAENPKAYMGPVVDKEAYDRILGTIAEA-EKNHKLLFKGSVP-------GGGFFAP 858 Query: 375 PCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRV 434 P + + D + EIFGPV++++ + L+ AN T + L GVF+R +RV Sbjct: 859 PTIFGDVPGDAKLAQAEIFGPVVAVIRAKNLDQALDIANSTEYALTGGVFSRSPANINRV 918 Query: 435 VAELQAGTCFINNYNVSPV--ELPFGGYKKSGFGRE-NGRVTIEYYSQLKTVCVE 486 EL+ G ++N + PFGG+K SG G + G ++ Y + V Sbjct: 919 KEELEVGNLYVNRGITGAMVDRHPFGGFKMSGIGSKTGGPDYLKQYMEPACVTEN 973 >4OGD-A nrPDB Length = 465 Score = 461 bits (1186), Expect = e-130, Method: Composition-based stats. Identities = 134/466 (28%), Positives = 208/466 (44%), Gaps = 9/466 (1%) Query: 29 EKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKS-GMERCRILLEAARIIRER 87 + P T V+ TF ++ + ++ A +K W ++ ER L + A I+R Sbjct: 3 YQTIYPYTNEVLHTFDNMTDQGLADVLERAHLLYKKWRKEDHLEERKAQLHQVANILRRD 62 Query: 88 EDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPL 147 D+ A + + GK EA+ ++D+ +YYA A Y ++ Sbjct: 63 RDKYAEIMTKDMGKLFTEAQGEVDLCADIADYYADKADEFLMSTPLETDSGQAYYLKQST 122 Query: 148 GVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPG-LF 206 GV + + WN+P+ AP GN MV K + P SA E+ EAG G + Sbjct: 123 GVILAVEPWNFPYYQIMRVFAPNFIVGNPMVLKHASICPRSAQSFEELVLEAGAEAGSIT 182 Query: 207 NVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSD 266 N+ Q + V V TGS G I E + K +K TLELGG II D Sbjct: 183 NLFISYDQVSQVIA-DKRVVGVCLTGSERGGASIAEEAGKNLKKTTLELGGDDAFIILDD 241 Query: 267 CDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTR 326 D + K + GQVC + R V + D+F E + K + K GDP+ +T Sbjct: 242 ADWDQLEKVLYFSRLYNAGQVCTSSKRFIVLDKDYDRFKELLTKVFKTAKWGDPMDPETT 301 Query: 327 MGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMT 386 + PL + VL +K+A + GA+++ GG+ G+++ P ++ D Sbjct: 302 LAPLSSAQAKADVLDQIKLALDHGAELVYGGEAIDH------PGHFVMPTIIAGLTKDNP 355 Query: 387 CVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFIN 446 +EIFGPV I +E E +E AND+ +GL +F+ + + A V A+++ G FIN Sbjct: 356 IYYQEIFGPVGEIYKVSSEEEAIEVANDSNYGLGGTIFSSNQEHAKAVAAKIETGMSFIN 415 Query: 447 NYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDVES 492 + S ELPFGG K SG+GRE + + + + S Sbjct: 416 SGWTSLPELPFGGIKHSGYGRELSELGFTSFVNEHLIYIPNKTNNS 461 >3PRL-A nrPDB Length = 505 Score = 459 bits (1182), Expect = e-129, Method: Composition-based stats. Identities = 143/483 (29%), Positives = 226/483 (46%), Gaps = 21/483 (4%) Query: 15 RGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERC 74 R G VE + PA+G + + ++EVN A+Q AK A KIW + ER Sbjct: 16 RNGEWVE-SRTGERISISAPASGVALGSIPALSQEEVNDAIQGAKDAQKIWKIRPIHERV 74 Query: 75 RILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQL 134 +L A ++ ER++ I + K A ++ + + + A A + GE ++ Sbjct: 75 DLLYAWADLLEERKEIIGELIMHEVAKPKKSAIGEVSRTADIIRHTADEALRLNGETLKG 134 Query: 135 P------GGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVS 188 REPLGV + I +NYP +A+ K APAL GN +VFKP+ +S Sbjct: 135 DQFKGGSSKKIALVEREPLGVVLAISPFNYPVNLAAAKIAPALVTGNTVVFKPATQGSLS 194 Query: 189 ALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKG 247 + + E ++AG P G+ VV G G+ G L +HP + ++FTG TG +I E + Sbjct: 195 GIKMVEALADAGAPEGIIQVVTGRGSVIGDHLVEHPGIDMITFTGGTTTGERISEKA--K 252 Query: 248 IKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEE 307 + PV LELGGK P I+ D D+ + F GQ C RVFVQ + D+ Sbjct: 253 MIPVVLELGGKDPAIVLDDADLKLTASQIVSGAFSYSGQRCTAIKRVFVQDSVADQLVAN 312 Query: 308 VVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKL 367 + + +++ +G P D + P+I+ + G + A E GA +L G Sbjct: 313 IKELVEQLTVGSPED-DADITPVIDEKSAAFIQGLIDDALENGATLLSGNK--------- 362 Query: 368 KDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRD 427 + G + P +L + M EE FGPV+ I+ E + +N + +GL A +FT+D Sbjct: 363 RQGNLLSPTLLDDVTPAMRVAWEEPFGPVLPIIRVKDANEAISLSNQSDYGLQASIFTKD 422 Query: 428 IQRAHRVVAELQAGTCFINNYN-VSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 486 RA + L+ GT IN P PF G KKSG G + + ++ ++ + + Sbjct: 423 TDRAINIGKHLEVGTVHINAKTERGPDHFPFLGVKKSGLGVQGIKPSLLSMTRERVTVLN 482 Query: 487 MGD 489 + + Sbjct: 483 LAE 485 >5N5S-A nrPDB Length = 515 Score = 455 bits (1171), Expect = e-128, Method: Composition-based stats. Identities = 128/466 (27%), Positives = 226/466 (48%), Gaps = 19/466 (4%) Query: 29 EKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIRERE 88 T V A + K+++ A+ A AA + ER +L + ++ R Sbjct: 56 LDVTNKYTNDVAAKVPQATHKDIDDAIDAAVAAAPAMAAMGAYERKAVLEKVVAELKNRF 115 Query: 89 DEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLP-----GGSFGYTR 143 +EIA + +GK I +AR ++ + + A + + GEHI L G G + Sbjct: 116 EEIAQTLTMESGKPIKDARGEVTRTIDTFQVAAEESVRIYGEHIPLDISARNKGLQGIVK 175 Query: 144 REPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEA-GVP 202 + P+G + WN+P + + K APA+A G V KP+ TP+SAL+L EI + +P Sbjct: 176 KFPIGPVSMVSPWNFPLNLVAHKVAPAIAVGCPFVLKPASRTPLSALILGEILHKIEELP 235 Query: 203 PGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLI 262 G F+++ ++FTGS P G + + K K V +ELGG +P I Sbjct: 236 LGAFSILPVSREDADMFTVDERFKLLTFTGSGPIGWDMKARAGK--KKVVMELGGNAPCI 293 Query: 263 IFSDC-DMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPL 321 + D++ ++ + F GQ C + R++V + + D+ E V +++K+G+P Sbjct: 294 VDDYVPDLDYTIQRLINGGFYQGGQSCIHMQRLYVHERLYDEVKEGFVAAVKKLKMGNPF 353 Query: 322 LEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNC 381 EDT +GP+I+ + + +VK A +G K+L GG+ + G ++ P V+ + Sbjct: 354 EEDTYLGPMISESAAKGIEDWVKEAVAKGGKLLTGGN---------RKGAFIEPTVIEDV 404 Query: 382 RDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAG 441 + KEEIFGPV+ + + E ++ N+T +GL +G+FT+D+ +A ++ G Sbjct: 405 PIEANARKEEIFGPVVLLYKYSDFKEAVKECNNTHYGLQSGIFTKDLNKAFYAFEHMEVG 464 Query: 442 TCFINNYNVSPVE-LPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 486 +N+ V+ P+GG K SG RE + ++ + K + + Sbjct: 465 GVILNDSPALRVDSQPYGGLKDSGIQREGVKYAMDDMLETKVLVMR 510 >4E4G-A nrPDB Length = 521 Score = 453 bits (1165), Expect = e-127, Method: Composition-based stats. Identities = 141/484 (29%), Positives = 240/484 (49%), Gaps = 11/484 (2%) Query: 10 QPLNYRGGARVEPADASGTE----KAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIW 65 Q + Y G ++ +GT F PATG V T + + ++ AV++AKAA W Sbjct: 21 QSMMYELGHFIDGKRVAGTSGRVSNIFNPATGEVQGTVALASDADLAAAVESAKAAQPKW 80 Query: 66 SQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAA 125 + + R R+ ++ +++ + +E+A M +GK+I +A+ DI + E+ G+ Sbjct: 81 AATNPQRRARVFMKFVQLLNDNMNELAEMLSREHGKTIDDAKGDIVRGLEVCEFVIGIPH 140 Query: 126 SMAGEHIQLPG-GSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPF 184 E + G G Y+ R+P+G+ GI +N+P I W APA+ACGNA + KPS Sbjct: 141 LQKSEFTEGAGPGIDMYSIRQPVGIGAGITPFNFPGMIPMWMFAPAIACGNAFILKPSER 200 Query: 185 TPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMS 244 P + LAE+ EAG+P G+ NVV G + HPD+A VSF GS P + + Sbjct: 201 DPSVPIRLAELMIEAGLPAGILNVVNGDKGAVDAILTHPDIAAVSFVGSTPIARYVYGTA 260 Query: 245 AKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGT-RVFVQKEILDK 303 A K G K+ +II D D++ A + A + + G+ C + V V +E ++ Sbjct: 261 AMNGKRAQCFGGAKNHMIIMPDADLDQAANALIGAGYGSAGERCMAISVAVPVGEETANR 320 Query: 304 FTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPE 363 +++V + ++IG E MGP++ + +R+ + EQGAK++ G + + Sbjct: 321 LIDKLVPMVESLRIGPYTDEKADMGPVVTKEAEQRIRSLIDSGIEQGAKLVVDGRDFKLQ 380 Query: 364 DPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGV 423 ++G+++ C+ + DM K EIFGPV+S++ E L +G + Sbjct: 381 --GYENGHFIGGCLFDDVTPDMDIYKTEIFGPVLSVVRARNYEEALSLPMKHEYGNGVAI 438 Query: 424 FTRDIQRAHRVVAELQAGTCFINNYNVSP-VELPFGGYKKSGFGR--ENGRVTIEYYSQL 480 +TRD A + + G +N P FGG+K S FG ++G +I+++++ Sbjct: 439 YTRDGDAARDFASRINIGMVGVNVPIPVPLAYHSFGGWKSSSFGDLNQHGTDSIKFWTRT 498 Query: 481 KTVC 484 KT+ Sbjct: 499 KTIT 502 >5KF0-A nrPDB Length = 485 Score = 448 bits (1152), Expect = e-126, Method: Composition-based stats. Identities = 146/474 (30%), Positives = 224/474 (47%), Gaps = 19/474 (4%) Query: 21 EPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEA 80 E A+ + + +G+V + + ++ A+ A A K + R +L Sbjct: 21 EAVYANTDLEVTDKFSGKVATRVALADAQAIDAAIGAAVDAVKPMRELPAYRRQAVLDHC 80 Query: 81 ARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQL-----P 135 RER DE+A CI GK I ++R ++ + A + GE + L Sbjct: 81 VARFRERFDELAEALCIEAGKPINDSRGEVTRLIDTFRVASEEAVRIDGEVLNLEISARA 140 Query: 136 GGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEI 195 G GYTRR P+G C I +N+P +A+ K APALA G V KP+ TPV AL++AE+ Sbjct: 141 QGYTGYTRRVPIGPCSFISPFNFPLNLAAHKVAPALAAGCPFVLKPASRTPVGALIIAEV 200 Query: 196 YSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLEL 255 +E +P G F+V+ +SFTGS G + E + K K V LEL Sbjct: 201 LAETNLPKGAFSVLPAHRDGADLFTTDERFRLLSFTGSPAVGWALKEKAGK--KKVVLEL 258 Query: 256 GGKSPLIIFSDC--DMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQ 313 GG + I+ +D ++ V + GQ C R+ V + D +++V +T+ Sbjct: 259 GGNAAAIVDADQFEQLDYVVDRLAFGAYYQSGQSCIGVQRILVHASLYDTLRDKLVAKTR 318 Query: 314 RIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYM 373 +K+GDP T +GP+I+ R+ G++ A GAK++ GG + DG Sbjct: 319 SLKMGDPKDPSTFVGPMISESESRRLSGWMDAAVAAGAKIIAGGKV---------DGAMF 369 Query: 374 RPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHR 433 +L + + ++E FGPV + FD + L R ND+ FGL AGVFT + A R Sbjct: 370 EATLLEDVGREQDLYRKEAFGPVAILEKFDRFDDALARVNDSDFGLQAGVFTDSLTHAQR 429 Query: 434 VVAELQAGTCFINNYNVSPVE-LPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 486 EL+ G IN+ V+ +P+GG K SG GRE R IE ++ + + V Sbjct: 430 AWDELEVGGVVINDVPSFRVDNMPYGGVKDSGLGREGIRYAIEDMTEPRLMVVR 483 >5JRY-A nrPDB Length = 485 Score = 442 bits (1137), Expect = e-124, Method: Composition-based stats. Identities = 144/470 (30%), Positives = 222/470 (47%), Gaps = 19/470 (4%) Query: 25 ASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARII 84 A+ + + +G+V + K ++ A+ A A K + +R +L Sbjct: 25 ANTDLEVTDKYSGKVATRVALADAKAIDAAIGAAVDATKPMRELPAYKRQAVLDHCVARF 84 Query: 85 REREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQL-----PGGSF 139 RER DE+A CI GK I +A+ ++ + A + GE + L G Sbjct: 85 RERFDELAEALCIEAGKPINDAKGEVTRLIDTFRVASEEAVRIDGEVLNLEISARAQGYT 144 Query: 140 GYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEA 199 GYTRR P+G C I +N+P +A+ K APALA G V KP+ TPV AL++ E+ +E Sbjct: 145 GYTRRVPIGPCSFISPFNFPLNLAAHKVAPALAAGCPFVLKPASRTPVGALIIGEVLAET 204 Query: 200 GVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKS 259 +P G F+V+ +SFTGS G + E + K K V LELGG + Sbjct: 205 DLPKGAFSVLPAHRDGADLFTTDDRFRLLSFTGSPAVGWALKEKAGK--KKVVLELGGNA 262 Query: 260 PLIIFSD--CDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKI 317 I+ +D ++ V F GQ C R+ +I D ++++ +T+ +K+ Sbjct: 263 AAIVDADQLDRLDYVVDRLAFGAFYQSGQSCIGVQRILAHADIYDALRDKLIAKTRSLKM 322 Query: 318 GDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCV 377 GDP T +GP+I+ R+ G++ A GAK++ GG + DG + Sbjct: 323 GDPKDPSTFVGPMISESESRRLSGWMDAAVAAGAKIVAGGKV---------DGAMFEATL 373 Query: 378 LTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAE 437 L N D ++E FGP+ + FD + L R ND+ FGL AGVFT + + E Sbjct: 374 LENVGRDQDLYRKEAFGPIAILEKFDRFDDALARVNDSDFGLQAGVFTDSLAHTQQAWDE 433 Query: 438 LQAGTCFINNYNVSPVE-LPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 486 L+ G IN+ V+ +P+GG K SG GRE R IE ++ + + V Sbjct: 434 LEVGGVVINDVPSFRVDNMPYGGVKDSGLGREGIRYAIEDMTEPRLLVVR 483 >2J5N-A nrPDB Length = 516 Score = 440 bits (1131), Expect = e-124, Method: Composition-based stats. Identities = 144/483 (29%), Positives = 236/483 (48%), Gaps = 24/483 (4%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMER 73 Y GG V+ + + P+ V+ T +G+ E A++ A AFK W +R Sbjct: 41 YIGGEWVDTKERMVSLNPSAPS--EVVGTTAKAGKAEAEAALEAAWKAFKTWKDWPQEDR 98 Query: 74 CRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASM---AGE 130 R+LL+AA ++R R+ E+ GK+ EA D+ + +EYYA A A E Sbjct: 99 SRLLLKAAALMRRRKRELEATLVYEVGKNWVEASADVAEAIDFIEYYARAALRYRYPAVE 158 Query: 131 HIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSAL 190 + PG + PLG V I WN+P I + +A GN ++ KP+ V Sbjct: 159 VVPYPGED-NESFYVPLGAGVVIAPWNFPVAIFTGMIVGPVAVGNTVIAKPAEDAVVVGA 217 Query: 191 LLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK--- 246 + EI+ EAG PPG+ N + G G G +L +HP + ++FTGS+ G+KI E + + Sbjct: 218 KVFEIFHEAGFPPGVVNFLPGVGEEVGAYLVEHPRIRFINFTGSLEVGLKIYEAAGRLAP 277 Query: 247 ---GIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDK 303 K +E GGK +I+ D + A +G +++ + QGQ C +R+ + + + Sbjct: 278 GQTWFKRAYVETGGKDAIIVDETADFDLAAEGVVVSAYGFQGQKCSAASRLILTQGAYEP 337 Query: 304 FTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPE 363 E V+K+ +R+ +G P E+ +GP+++ +VL ++++ K +G ++ GG Sbjct: 338 VLERVLKRAERLSVG-PAEENPDLGPVVSAEQERKVLSYIEIGKNEGQ-LVLGGKRL--- 392 Query: 364 DPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGV 423 +GY++ P V T +EEIFGPV+S++ AE LE ANDT +GL GV Sbjct: 393 ---EGEGYFIAPTVFTEVPPKARIAQEEIFGPVLSVIRVKDFAEALEVANDTPYGLTGGV 449 Query: 424 FTRDIQRAHRVVAELQAGTCFINNYNVSPV--ELPFGGYKKSGFGRENG-RVTIEYYSQL 480 ++R + E G + N + PFGG+K SG + G + + ++ Sbjct: 450 YSRKREHLEWARREFHVGNLYFNRKITGALVGVQPFGGFKLSGTNAKTGALDYLRLFLEM 509 Query: 481 KTV 483 K V Sbjct: 510 KAV 512 >5J6B-A nrPDB Length = 485 Score = 438 bits (1126), Expect = e-123, Method: Composition-based stats. Identities = 139/474 (29%), Positives = 219/474 (46%), Gaps = 19/474 (4%) Query: 21 EPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEA 80 E A+ + + TG+V + ++ A+ A A K R IL Sbjct: 21 EAVYANAELEVTDKYTGKVATRVALADASAIDAAIAAAVGAQKPLRALPAFRRQAILEHC 80 Query: 81 ARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAG-----EHIQLP 135 RER DE+A CI GK I +++ ++ A + + G E Sbjct: 81 VARFRERFDELAQALCIEAGKPINDSKGEVTRLIDTFRVAAEESVRIEGGLVNLEISPRA 140 Query: 136 GGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEI 195 G GY +R P+G C I +N+P +A+ K APALA G V KP+ TP+ AL++ E+ Sbjct: 141 QGYSGYYKRVPIGPCSFISPFNFPLNLAAHKVAPALAAGCPFVLKPASRTPIGALIIGEV 200 Query: 196 YSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLEL 255 +E +P G F+++ +SFTGS G ++ + + K V LEL Sbjct: 201 LAETDLPKGAFSILPAHRDGADLFTTDERFKLLSFTGSPTVGWELKKKAGKKK--VVLEL 258 Query: 256 GGKSPLIIFSDCD--MNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQ 313 GG + I+ +D ++ V+ + GQ C R+ ++ D E+++ +T+ Sbjct: 259 GGNAAAIVDADQREVLDYVVERLAFGAYYQSGQSCIGVQRIIAHADVYDALREKLIAKTR 318 Query: 314 RIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYM 373 +K+GDP T +GP+I+ R+ G+++ A GAK++ GG + DG Sbjct: 319 SLKMGDPKDPATFVGPMISESEARRLAGWMEAAVAAGAKIVAGGKV---------DGAMF 369 Query: 374 RPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHR 433 +L D ++E FGPV + F + L R ND+ FGL AGVFT + A R Sbjct: 370 EATLLEGVGRDQDLYRKEAFGPVALLERFSDFDDALARVNDSDFGLQAGVFTDSLSHAQR 429 Query: 434 VVAELQAGTCFINNYNVSPVE-LPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 486 EL+ G IN+ V+ +P+GG K SG GRE R IE ++L+ + V Sbjct: 430 AWDELEVGGVVINDVPSFRVDNMPYGGVKDSGLGREGIRYAIEDMTELRLMVVR 483 >5U0M-A nrPDB Length = 497 Score = 428 bits (1100), Expect = e-120, Method: Composition-based stats. Identities = 130/467 (27%), Positives = 216/467 (46%), Gaps = 14/467 (2%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMER 73 Y G + ++ +P TG + + ++V+ AV+ A+ AF W +KS ER Sbjct: 15 YIDGLWLPG--HGAPFESVQPVTGETVWDGNAASLEDVDAAVREARKAFLAWRRKSLAER 72 Query: 74 CRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQ 133 ++ ++ ++E+A + GK ++E+R ++ + G Sbjct: 73 QAVIEAFGELLEANKEELAHQIGLETGKPLWESRTEVAAMMGKIPISVKAYNERTGHTES 132 Query: 134 LPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLA 193 G R P GV G +N+P + + PAL GN +VFKPS TP A L Sbjct: 133 DVAGGHAVLRHRPHGVVAVFGPYNFPGHLPNGHIVPALLAGNTVVFKPSELTPGVAELTV 192 Query: 194 EIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEM-SAKGIKPVT 252 ++ +AG+P G+ N+VQGG+ TG+ L +H + + FTGS G + E + K + Sbjct: 193 RLWEKAGLPDGVINLVQGGSDTGKCLARHSLIDGLFFTGSSTVGHLLHEQFGGQPEKILA 252 Query: 253 LELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEIL-DKFTEEVVKQ 311 LE+GG +PLI+ + D++ AV AL + FL+ GQ C R+ V K D+F +V+ Sbjct: 253 LEMGGNNPLIVQNVSDLDGAVHHALQSAFLSAGQRCTCARRLLVPKGKKGDEFLARLVEV 312 Query: 312 TQRIKIGD-PLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDG 370 RI + + MG +I+ ++L E+GA L P+ L G Sbjct: 313 AARITVAEFDADPQPFMGSVISAEAANQLLKAQAAMLEKGATSLLEMKQLKPDTGLLSPG 372 Query: 371 YYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQR 430 + + + +E FGP++++ + E LE AN+T +GL+AG+ + D + Sbjct: 373 -------IVDAT-GIELEDQEFFGPLLTVYRYKGFDEALELANNTRYGLSAGILSDDRKL 424 Query: 431 AHRVVAELQAGTCFINNYNVSP-VELPFGGYKKSGFGRENGRVTIEY 476 +R+V E++AG N PFGG SG R + +Y Sbjct: 425 YNRLVEEVRAGIVNWNRPLTGASSAAPFGGVGASGNHRPSAYYAADY 471 >6DBB-A nrPDB Length = 511 Score = 419 bits (1077), Expect = e-117, Method: Composition-based stats. Identities = 123/471 (26%), Positives = 219/471 (46%), Gaps = 21/471 (4%) Query: 33 EPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIA 92 P G +AT + + A AF W R ++ ++RE + E+ Sbjct: 34 SPLDGATLATLAVDTPADAERKIDAAHDAFLKWRTVPAPVRGELVRVFGNVLREHKAELG 93 Query: 93 TMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHI--QLPGGSFGYTRREPLGVC 150 + + GK E ++ ++ GL+ + G I + PG T P+GVC Sbjct: 94 RLVTLEAGKITSEGLGEVQEMIDICDFAVGLSRQLYGLTIASERPGHRMMETWH-PIGVC 152 Query: 151 VGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEA---------GV 201 I A+N+P + +W +A A CG+++V+KPS TP++A+ + +A GV Sbjct: 153 GVISAFNFPVAVWAWNAALAFVCGDSVVWKPSEKTPLTAIACHVLLQKALREFEKTHPGV 212 Query: 202 -PPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSP 260 P L +V G G+ L V VS TGSV G ++ ++ ++ + LELGG + Sbjct: 213 APAELGQLVLGMRDVGEVLTASKKVPVVSATGSVRMGQEVAKVLSQRLARGILELGGNNG 272 Query: 261 LIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDP 320 +I+ D++ V+ A T GQ C R+ V + ++++ + K +K+G+P Sbjct: 273 MIVAPSADLDLVVRAVTFAAVGTAGQRCTTLRRLIVHRSLVEQLLPRIEKAYASVKVGNP 332 Query: 321 LLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTN 380 L E T +GPL++R + + + A+EQG +V G + D D YY+RP ++ Sbjct: 333 LEEGTLVGPLVDRASFDAMQKALADAREQGGEVKGGERV----DVGHADAYYVRPAIVRM 388 Query: 381 CRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRV--VAEL 438 + V+ E F P++ ++ +D + ++ N GL++ +FT D++ A + A Sbjct: 389 PKQSA-VVERETFAPILYVMVYDNFDDAIDVHNAVPQGLSSAIFTNDMREAEQFMSAAGS 447 Query: 439 QAGTCFIN-NYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMG 488 G +N + + + FGG K++G GRE+G + Y + T + Sbjct: 448 DCGIVNVNIGTSGAEIGGAFGGEKETGGGRESGSDAWKAYMRRATNTINYS 498 >3SZA-A nrPDB Length = 469 Score = 417 bits (1072), Expect = e-117, Method: Composition-based stats. Identities = 126/452 (27%), Positives = 206/452 (45%), Gaps = 23/452 (5%) Query: 43 FTCSG-EKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGK 101 +++ AV+ A+AAF + R + L R+I+E+E E+ + K Sbjct: 11 VPRGSHMSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHK 70 Query: 102 SIFEARLD-IDISWQCLEYYA----GLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAW 156 + + A + + + +EY AA E Y EPLGV + IG W Sbjct: 71 NEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTW 130 Query: 157 NYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATG 216 NYPF + A+A GNA+V KPS + A LLA I + + L+ V+ GG Sbjct: 131 NYPFNLTIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPET 189 Query: 217 QFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGA 276 L + + +TGS G IM +AK + PVTLELGGKSP + +CD++ A + Sbjct: 190 TELLK-ERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRI 248 Query: 277 LMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHL 336 F+ GQ C + I ++ E++ K + G+ + G +I+ H Sbjct: 249 AWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHF 307 Query: 337 ERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPV 396 +RV+G + +G KV GG Y+ P +LT+ ++EEIFGPV Sbjct: 308 QRVMGLI-----EGQKVAYGGTGDAAT-------RYIAPTILTDVDPQSPVMQEEIFGPV 355 Query: 397 MSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN--YNVSPVE 454 + I+ + E ++ N LA +F+ + + +++AE +G N+ +++ Sbjct: 356 LPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHS 415 Query: 455 LPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 486 LPFGG SG G +G+ + E +S ++ V Sbjct: 416 LPFGGVGNSGMGSYHGKKSFETFSHRRSCLVR 447 >1UXV-A nrPDB Length = 501 Score = 412 bits (1060), Expect = e-115, Method: Composition-based stats. Identities = 134/484 (27%), Positives = 206/484 (42%), Gaps = 23/484 (4%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNA-KAAFKIWSQKSGME 72 Y G + + P IA +EV + K G E Sbjct: 22 YLAGEW---GGSGQEIEVKSPIDLATIAKVISPSREEVERTLDVLFKRGRWSARDMPGTE 78 Query: 73 RCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHI 132 R +L +AA II D A + +N GK A ++ + L + G++I Sbjct: 79 RLAVLRKAADIIERNLDVFAEVLVMNAGKPKSAAVGEVKAAVDRLRLAELDLKKIGGDYI 138 Query: 133 QLP-----GGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPV 187 + G RREPLGV I +NYP A K + GNA+V KPS P+ Sbjct: 139 PGDWTYDTLETEGLVRREPLGVVAAITPFNYPLFDAVNKITYSFIYGNAVVVKPSISDPL 198 Query: 188 SALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKG 247 A + + +AG PP ++ + + VA VSFTGS G +++++ Sbjct: 199 PAAMAVKALLDAGFPPDAIALLNLPGKEAEKIVADDRVAAVSFTGSTEVGERVVKVGG-- 256 Query: 248 IKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEE 307 +K +ELGG P I+ D D++ A + GQ C V ++ + K EE Sbjct: 257 VKQYVMELGGGDPAIVLEDADLDLAADKIARGIYSYAGQRCDAIKLVLAERPVYGKLVEE 316 Query: 308 VVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKL 367 V K+ +++GDP +GPLI+ ++ ++ ++ A E+G +VL GG P Sbjct: 317 VAKRLSSLRVGDPRDPTVDVGPLISPSAVDEMMAAIEDAVEKGGRVLAGGRRLGPT---- 372 Query: 368 KDGYYMRPCVLTNCRD---DMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVF 424 Y++P ++ D DM K E+F PV + + +E AN +GL A VF Sbjct: 373 ----YVQPTLVEAPADRVKDMVLYKREVFAPVALAVEVKDLDQAIELANGRPYGLDAAVF 428 Query: 425 TRDIQRAHRVVAELQAGTCFINNYNVSPV-ELPFGGYKKSGFGRENGRVTIEYYSQLKTV 483 RD+ + R V L+ G +IN+ + PFGG KKSG RE +E + KT+ Sbjct: 429 GRDVVKIRRAVRLLEVGAIYINDMPRHGIGYYPFGGRKKSGVFREGIGYAVEAVTAYKTI 488 Query: 484 CVEM 487 Sbjct: 489 VFNY 492 >3JU8-A nrPDB Length = 490 Score = 408 bits (1048), Expect = e-114, Method: Composition-based stats. Identities = 119/459 (25%), Positives = 203/459 (44%), Gaps = 13/459 (2%) Query: 13 NYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGME 72 +Y G + A T ++ +P V+ + + +V+ AV A+ AF W+++ + Sbjct: 8 HYIAGQWL--AGQGETLESLDPVGQGVVWSGRGADATQVDAAVCAAREAFPAWARRPLEQ 65 Query: 73 RCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHI 132 R +L A ++ R DE+A + GK ++E+ ++ + GE Sbjct: 66 RIELLERFAATLKSRADELARVIGEETGKPLWESATEVTSMVNKVAISVQAFRERTGEKS 125 Query: 133 QLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLL 192 + R +P GV G +N+P + + PAL GN +VFKPS TP A L Sbjct: 126 GPLADATAVLRHKPHGVVAVFGPYNFPGHLPNGHIVPALLAGNCVVFKPSELTPKVAELT 185 Query: 193 AEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEM-SAKGIKPV 251 + + +AG+P G+ N+VQGG TG L H + + FTGS TG + + K + Sbjct: 186 LKAWIQAGLPAGVLNLVQGGRETGVALAAHRGLDGLFFTGSSRTGNLLHSQFGGQPQKIL 245 Query: 252 TLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEIL-DKFTEEVVK 310 LE+GG +PL++ D++ AV + + F++ GQ C R+ V + D +V Sbjct: 246 ALEMGGNNPLVVEEVADLDAAVYTIIQSAFISAGQRCTCARRLLVPQGAWGDALLARLVA 305 Query: 311 QTQRIKIGD-PLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKD 369 + +++G MG +I+ E +L + +GA + + Sbjct: 306 VSATLRVGRFDEQPAPFMGAVISLSAAEHLLKAQEHLIGKGA------QPLLAMTQPIDG 359 Query: 370 GYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQ 429 + P +L + EE FGP++ ++ + A + AN T +GLAAG+ + + Sbjct: 360 AALLTPGIL-DVSAVAERPDEEFFGPLLQVIRYSDFAAAIREANATQYGLAAGLLSDSRE 418 Query: 430 RAHRVVAELQAGTCFINNYNVSPV-ELPFGGYKKSGFGR 467 R + + E +AG N PFGG SG R Sbjct: 419 RFEQFLVESRAGIVNWNKQLTGAASSAPFGGIGASGNHR 457 >4KNA-A nrPDB Length = 495 Score = 403 bits (1035), Expect = e-112, Method: Composition-based stats. Identities = 128/458 (27%), Positives = 199/458 (43%), Gaps = 13/458 (2%) Query: 14 YRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMER 73 + GA V+ A + P T + + +V AV +A+ AF WS R Sbjct: 13 FIDGAWVDGA--GPVFASRNPGTNERVWEGASASADDVERAVASARRAFAAWSALDLDAR 70 Query: 74 CRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQ 133 C I+ A ++ ER++ +ATM GK ++EAR ++ ++ GE Sbjct: 71 CTIVKRFAALLVERKEALATMIGRETGKPLWEARTEVASMAAKVDISITAYHERTGEKRA 130 Query: 134 LPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLA 193 R P GV G +N+P + + PAL GN +VFKPS P A Sbjct: 131 PMADGVAVLRHRPHGVVAVFGPYNFPGHLPNGHIVPALIAGNTVVFKPSELAPGVARATV 190 Query: 194 EIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPV-T 252 EI+ +AG+P G+ N+VQG TG L H + + FTGS TG + + + V Sbjct: 191 EIWRDAGLPAGVLNLVQGEKDTGVALANHRQIDGLFFTGSSDTGTLLHKQFGGRPEIVLA 250 Query: 253 LELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEIL-DKFTEEVVKQ 311 LE+GG +PL++ D++ AV A+ + FL+ GQ C R+ V + D+F + Sbjct: 251 LEMGGNNPLVVAEVEDIDAAVHHAIQSAFLSAGQRCTCARRILVPRGAFGDRFVARLADV 310 Query: 312 TQRIKIGD-PLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDG 370 +I MG +I+ R++ Q V G + + Sbjct: 311 ASKITASVFDADPQPFMGAVISARAASRLVA------AQARLVGLGASPIIEMKQRDPAL 364 Query: 371 YYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQR 430 ++ +L + + EE FGP+ I+ + + + RANDT FGL+AG+ D Q Sbjct: 365 GFVNAAIL-DVTNVRELPDEEHFGPLAQIVRYTDLDDAIARANDTAFGLSAGLLADDEQA 423 Query: 431 AHRVVAELQAGTCFINNY-NVSPVELPFGGYKKSGFGR 467 H ++AG N N + PFGG +SG R Sbjct: 424 WHTFRRAIRAGIVNWNRPTNGASSAAPFGGAGRSGNHR 461 >3V9H-A nrPDB Length = 566 Score = 393 bits (1011), Expect = e-110, Method: Composition-based stats. Identities = 125/489 (25%), Positives = 218/489 (44%), Gaps = 29/489 (5%) Query: 15 RGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERC 74 G V +D F G +A F + + +N A++ A AA K W K +R Sbjct: 71 VGDEEVWTSDVQYQVSPFN--HGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRA 128 Query: 75 RILLEAARIIR-EREDEIATMECINNGKSIFEARLDID-ISWQCLEYYAGLAASMAGE-H 131 +I L+AA ++ R EI + GK++ +A +D + A A + G+ Sbjct: 129 QIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQP 188 Query: 132 IQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALL 191 I +P + R G I +N+ + APAL GN +++KPS +++ Sbjct: 189 ISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPAL-MGNVVLWKPSDTAMLASYA 247 Query: 192 LAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGI-- 248 + I EAG+PP + V G G + + ++FTGSVPT + + A+ + Sbjct: 248 VYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDR 307 Query: 249 ----KPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKF 304 + E GGK+ + D+ + V G L + F GQ C R++V + + Sbjct: 308 FHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACARLYVPHSLWPQI 367 Query: 305 TEEVVKQTQRIKIGDPLLE-DTRMGPLINRPHLERVLGFVKVAKEQGA-KVLCGGDIYVP 362 ++++ RIK+GDP + T +I+ R+ +++ A+ + +L GG Sbjct: 368 KGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKC--- 424 Query: 363 EDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSF--DTEAEVLERANDTT-FGL 419 GY++ PC++ + +KEEIFGPV+S+ + D E L+ + TT +GL Sbjct: 425 ---DDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGL 481 Query: 420 AAGVFTRDIQRAHRVVAELQ--AGTCFINNYNVSPV--ELPFGGYKKSGFG-RENGRVTI 474 VF++D L+ AG +IN+ + + + PFGG + SG + G I Sbjct: 482 TGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYI 541 Query: 475 EYYSQLKTV 483 ++ + + Sbjct: 542 LRWTSPQVI 550 >4I3V-A nrPDB Length = 488 Score = 393 bits (1010), Expect = e-109, Method: Composition-based stats. Identities = 138/475 (29%), Positives = 218/475 (45%), Gaps = 26/475 (5%) Query: 24 DASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARI 83 D + P V+ T + A A A + + ER +ILL A Sbjct: 26 DTDDRVEVRYPWNDTVVGTVPAGRAEHAREAFAIAAAYQP---KLTRYERQKILLATAEA 82 Query: 84 IREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLP-----GGS 138 + R++EI+ + + G S ++ ++ ++ + GE Sbjct: 83 LAARKEEISDVITLELGISKADSLYEVGRAFDVFTLAGQMCIRDDGEIFSCDLTPHGKAR 142 Query: 139 FGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSE 198 +T REPL I +N+P + + K APA+A N +V KP+ TP++ALLLA+I E Sbjct: 143 KIFTMREPLTAISAITPFNHPLNMVAHKVAPAIATNNCVVVKPTELTPMTALLLADILYE 202 Query: 199 AGVPPGLFNVVQGGA-ATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGG 257 AG+PP + +VV G G + +P V V+FTGSVP G I + K LELGG Sbjct: 203 AGLPPEMLSVVTGWPADIGMEMITNPHVDLVTFTGSVPVGKLIAANA--HYKRQVLELGG 260 Query: 258 KSPLII---FSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQR 314 PLII SD D+ A A+ GQ C R+ Q+ + D+F V+++ +R Sbjct: 261 NDPLIILNDLSDDDLARAADLAVAGATKNSGQRCTAVKRILCQESVADRFVPLVLERAKR 320 Query: 315 IKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMR 374 ++ GDP+ T +G +I+ V A E+GA +L + G + Sbjct: 321 LRFGDPMDRSTDLGTVIHEKAAALFEERVMRAAEEGADILY---------HPGRSGALLP 371 Query: 375 PCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEV-LERANDTTFGLAAGVFTRDIQRAHR 433 P V+ V EE FGP++ I+ + + + +N T FGL++GV T D +R + Sbjct: 372 PIVVDRVPHQSDLVLEETFGPIIPIVRVPDDDDATITLSNSTAFGLSSGVCTNDYRRMQK 431 Query: 434 VVAELQAGTCFINNYNVSPVEL-PFGGYKKSGFG-RENGRVTIEYYSQLKTVCVE 486 +A L+ GT I +E+ PFGG K SG G +E ++ ++ +KT + Sbjct: 432 YIAGLKVGTVNIWEVPGYRIEMSPFGGIKDSGNGYKEGVIEAMKSFTNVKTFSLP 486 >1AD3-A nrPDB Length = 452 Score = 392 bits (1008), Expect = e-109, Method: Composition-based stats. Identities = 122/443 (27%), Positives = 199/443 (44%), Gaps = 22/443 (4%) Query: 51 VNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLD- 109 ++ V+ A+ AF +S R + L R+I E I+ + GK+ + + + Sbjct: 3 ISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEE 62 Query: 110 IDISWQCLEYYA----GLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASW 165 + + L+ A + Y EPLGV + IGAWNYPF + Sbjct: 63 VAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQ 122 Query: 166 KSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDV 225 A+A GNA++ KPS + A LLA + + + L+ VV+GG L + Sbjct: 123 PMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLK-ERF 180 Query: 226 AKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQG 285 + +TGS G +M +AK + PVTLELGGKSP + DCD++ A + F+ G Sbjct: 181 DHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSG 240 Query: 286 QVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKV 345 Q C + I ++ E++ K + G+ + G +IN H +RV G + Sbjct: 241 QTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGLIDN 299 Query: 346 AKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTE 405 KV GG Y+ P +L + ++EEIFGPVM I+ + Sbjct: 300 -----QKVAHGGTWDQSS-------RYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSL 347 Query: 406 AEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN--YNVSPVELPFGGYKKS 463 E ++ N LA VF+ + + +++AE +G N+ +++ LPFGG S Sbjct: 348 EEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNS 407 Query: 464 GFGRENGRVTIEYYSQLKTVCVE 486 G G +G+ + E +S ++ V+ Sbjct: 408 GMGAYHGKKSFETFSHRRSCLVK 430 >4LGZ-A nrPDB Length = 563 Score = 391 bits (1005), Expect = e-109, Method: Composition-based stats. Identities = 126/489 (25%), Positives = 219/489 (44%), Gaps = 29/489 (5%) Query: 15 RGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERC 74 G V +D F A +A F + + +N A+ A AA K W K +R Sbjct: 68 VGDEEVWTSDIQYQLSPFNHA--HKVAKFCYADKALLNRAIDAALAARKEWDLKPMADRA 125 Query: 75 RILLEAARIIR-EREDEIATMECINNGKSIFEARLDID-ISWQCLEYYAGLAASMAGE-H 131 ++ L+AA ++ R E+ + GK++ +A +D + A A + GE Sbjct: 126 QVFLKAADMLSGPRRAEVLAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKFAVELEGEQP 185 Query: 132 IQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALL 191 I +P + R G I +N+ + APAL GN +++KPS +++ Sbjct: 186 ISVPPSTNHTVYRGLEGFVAAISPFNFTAIGGNLAGAPAL-MGNVVLWKPSDTAMLASYA 244 Query: 192 LAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGI-- 248 + I EAG+PP + V G G + + ++FTGSVPT + A+ + Sbjct: 245 VYRILREAGLPPNIIQFVPADGPTFGDTVTSSEHLCGINFTGSVPTFKHLWRQVAQNLDR 304 Query: 249 ----KPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKF 304 + E GGK+ + S D+++ V G L + F GQ C +R++V K + + Sbjct: 305 FRTFPRLAGECGGKNFHFVHSSADVDSVVSGTLRSAFEYGGQKCSACSRLYVPKSLWPQI 364 Query: 305 TEEVVKQTQRIKIGDPLLE-DTRMGPLINRPHLERVLGFVKVAKEQGA-KVLCGGDIYVP 362 ++++ RIK+GDP + T +I+ R+ +++ A+ + +L GG Sbjct: 365 KGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKAFARIKKWLEHARSSPSLSILAGGQC--- 421 Query: 363 EDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEA--EVLERANDTT-FGL 419 GYY+ PC++ + +KEEIFGPV+++ + + E L+ + TT +GL Sbjct: 422 ---NESVGYYVEPCIIESKDPQEPIMKEEIFGPVLTVYVYPDDKYRETLKLVDSTTSYGL 478 Query: 420 AAGVFTRDIQRAHRVVAELQ--AGTCFINNYNVSPV--ELPFGGYKKSGFG-RENGRVTI 474 VF +D L+ AG +IN+ + V + PFGG + SG + G I Sbjct: 479 TGAVFAQDKAIVQEATRMLRNAAGNFYINDKSTGSVVGQQPFGGARASGTNDKPGGPHYI 538 Query: 475 EYYSQLKTV 483 ++ + + Sbjct: 539 LRWTSPQVI 547 >4QGK-A nrPDB Length = 461 Score = 383 bits (983), Expect = e-106, Method: Composition-based stats. Identities = 115/446 (25%), Positives = 201/446 (45%), Gaps = 28/446 (6%) Query: 51 VNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEAR--- 107 + L V+ + AF + R + L R+++ERE +I T + KS F Sbjct: 2 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 61 Query: 108 -----LDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQI 162 +ID + L + + L Y + +PLGV + IGAWNYPF + Sbjct: 62 VITVLGEIDFMLENLP---EWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVL 118 Query: 163 ASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQH 222 A+A GNA++ KPS + +A +LA++ + + L+ V+ GG L + Sbjct: 119 TIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLK- 176 Query: 223 PDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFL 282 + +TG+ G +ME +AK + PVTLELGGKSP I DCD++ + ++ Sbjct: 177 QRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYM 236 Query: 283 TQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGF 342 GQ C + + + ++ ++ + + G+ + E +IN H +R+L Sbjct: 237 NCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSL 295 Query: 343 VKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSF 402 + +G K+ GG+ Y+ P VLT+ ++EEIFGP++ I+ Sbjct: 296 L-----EGQKIAFGGETDEAT-------RYIAPTVLTDVDPKTKVMQEEIFGPILPIVPV 343 Query: 403 DTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNY--NVSPVELPFGGY 460 E + N+ LA VF+ + + R++ E +G N+ + + PFGG Sbjct: 344 KNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGV 403 Query: 461 KKSGFGRENGRVTIEYYSQLKTVCVE 486 SG G +G+ + + +S + ++ Sbjct: 404 GSSGMGAYHGKHSFDTFSHQRPCLLK 429 >4H7N-A nrPDB Length = 474 Score = 379 bits (975), Expect = e-105, Method: Composition-based stats. Identities = 123/480 (25%), Positives = 214/480 (44%), Gaps = 25/480 (5%) Query: 26 SGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIR 85 + T + P TG+ + + A+ A W + R L + + I Sbjct: 5 TKTIEVRNPRTGKFDYVIIPPPPRLLAQQCNRARRAQSRWQELGVEGRITTLQQWKQAIL 64 Query: 86 EREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASM---AGEHIQLPGGSFGYT 142 R +++ + G+ + L+ID ++ + GLA + + ++ +P + + Sbjct: 65 SRREQLTEALVNDTGR-LSITVLEIDSFLASIDRWCGLAPELLQTSAKNTSIPFIALQQS 123 Query: 143 RREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVP 202 P + I WN+P ++ + PAL G A+V KPS P +A + Sbjct: 124 L-VPYPLVGVISPWNFPLTLSMIDTIPALLAGCAVVVKPSEIAP---RFVAPLLMALNTV 179 Query: 203 P---GLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKS 259 P + V+GG TG L + V V FTGSV TG ++ E +A+ P LELGGK Sbjct: 180 PELRDVLIFVEGGGETGANLINY--VDFVCFTGSVATGREVAETAARRFIPAYLELGGKD 237 Query: 260 PLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGD 319 P I+ ++ A L + GQ C + R++V + ++F +++ + R+++ Sbjct: 238 PAIVLESANLELATSAILWGAVVNTGQSCLSIERIYVAESKFEEFYHQLIAKAHRLQLAY 297 Query: 320 PLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLT 379 PL+ED +GP+I + + A E+GA + CGG + +L G++ RP V+T Sbjct: 298 PLVEDGAIGPIIAEKQAGIINDHILDAVEKGAVIHCGGKV-----EELGGGWWCRPTVMT 352 Query: 380 NCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQ 439 N M + EE FGP+M ++ F E + ANDT +GL+A VF A +V +L Sbjct: 353 NVNHSMKVMTEETFGPIMPVMPFPDVEEAVYLANDTIYGLSAAVFAGSEDEALKVARQLN 412 Query: 440 AGTCFINNYNVSPVELPFGGYKK----SGF-GRENGRVTIEYYSQLKTVCVEMGDVESAF 494 AG IN+ ++ + G K SG G G ++ + + + ++ + Sbjct: 413 AGAISINDAALTA--MMHEGEKNAFNFSGLGGSRVGAAGLKRFLRKQAFLIKTNSTSDPW 470 >4OE4-A nrPDB Length = 580 Score = 364 bits (934), Expect = e-101, Method: Composition-based stats. Identities = 116/501 (23%), Positives = 215/501 (42%), Gaps = 41/501 (8%) Query: 15 RGGARVEPADASGTEKAFEPAT-GRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMER 73 G R+ + PA +V+A T + EK+V AV+ AK A K W +R Sbjct: 64 INGERIYDNNERALFPQTNPANHQQVLANVTQATEKDVMNAVKAAKDAKKDWYNLPFYDR 123 Query: 74 CRILLEAARII--REREDEIATMECINNGKSIFEARLD-IDISWQCLEYYAGLAASMAGE 130 I L+AA +I + R D +A + GK++++A +D I YY A+ + + Sbjct: 124 SAIFLKAADLISTKYRYDMLAATM-LGQGKNVYQAEIDCITELSDFFRYYVKYASDLYAQ 182 Query: 131 -HIQLPGGSFGYTRREPL-GVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVS 188 ++ G++ PL G + +N+ A+ APAL GN +V+KPS +S Sbjct: 183 QPVESADGTWNKAEYRPLEGFVYAVSPFNFTAIAANLIGAPAL-MGNTVVWKPSQTAALS 241 Query: 189 ALLLAEIYSEAGVPPGLFNVVQGGA-ATGQFLCQHPDVAKVSFTGSVPTGMKIM------ 241 LL + EAG+P G+ N + G + D + FTGS + Sbjct: 242 NYLLMTVLEEAGLPKGVINFIPGDPVQVTDQVLADKDFGALHFTGSTNVFKSLYGKIQSG 301 Query: 242 --EMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKE 299 E + + E GGK+ ++ ++++AV + F QGQ C +R+++ + Sbjct: 302 VVEGKYRDYPRIIGETGGKNFHLVHPSANISHAVLSTIRGTFEFQGQKCSAASRLYLPES 361 Query: 300 ILDKFTEEVVKQTQRIKI------GDPLLEDT---RMGPLINRPHLERVLGFVKVAKEQG 350 ++F ++ Q + P+ MGP+I+ ++++ ++ AK+ Sbjct: 362 KSEEFLSDMFGILQSQNVVPMNTSASPISGGNLRGFMGPVIHEQSFDKLVKVIEDAKKDP 421 Query: 351 A-KVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEA--E 407 ++L GG G+++ P V+ R D + E FGP++++ + E Sbjct: 422 ELEILYGGQY------DKSQGWFVGPTVIKAKRPDHPYMSTEFFGPILTVYEYPDTEFNE 475 Query: 408 VLERA-NDTTFGLAAGVFTRDIQRAHRVVAELQ--AGTCFINNYNVSPV--ELPFGGYKK 462 + + N + + L +F +D + +L+ AG +IN+ V + FGG + Sbjct: 476 ICDIIDNTSQYALTGAIFAKDRKAIEYADEKLKFSAGNFYINDKCTGAVVSQQWFGGARM 535 Query: 463 SGF-GRENGRVTIEYYSQLKT 482 SG + G + + ++ Sbjct: 536 SGTDDKAGGPNILSRFVSIRN 556 >5UCD-A nrPDB Length = 457 Score = 350 bits (899), Expect = 7e-97, Method: Composition-based stats. Identities = 109/447 (24%), Positives = 191/447 (42%), Gaps = 25/447 (5%) Query: 47 GEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEA 106 +++ KA F + R + L + ++ + + + GK Sbjct: 26 SPAKIDSLFSAQKAYFATRATADVGFRKQSLERLKEAVINNKEALYSALAEDLGKPKDVV 85 Query: 107 -RLDIDISWQCLEYYAGLAAS-MAGEHIQLPG---GSFGYTRREPLGVCVGIGAWNYPFQ 161 +I +++ +A + P S Y +EP GV IG +NYP Sbjct: 86 DLAEIGAVLHEIDFALAHLDEWVAPVSVPSPDIIAPSECYVVQEPYGVTYIIGPFNYPVN 145 Query: 162 IASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQ 221 + A+ GN + KPS TP ++ ++ +I +EA P V+QGG L Sbjct: 146 LTLTPLIGAIIGGNTCIIKPSETTPETSAVIEKIIAEA-FAPEYVAVIQGGRDENSHLLS 204 Query: 222 HPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANF 281 P + FTGS G +M+ +AK + PV LELGGK PLI+ D D++ V + F Sbjct: 205 LP-FDFIFFTGSPNVGKVVMQAAAKHLTPVVLELGGKCPLIVLPDADLDQTVNQLMFGKF 263 Query: 282 LTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLG 341 + GQ ++V + D E +V++ K P + T G L+ ++R++ Sbjct: 264 INSGQTXIAPDYLYVHYSVKDALLERLVERV---KTELPEINST--GKLVTERQVQRLVS 318 Query: 342 FVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILS 401 ++ + Q VL G V + + V+ + + EE+FGP++ +L Sbjct: 319 LLEATQGQ---VLVGSQADVSKRA-------LSATVVDGVEWNDPLMSEELFGPILPVLE 368 Query: 402 FDTEAEVLERAND-TTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNY--NVSPVELPFG 458 FD+ +++ N LA VF +D+ A ++ ++Q+G +N + LPFG Sbjct: 369 FDSVRTAIDQVNKHHPKPLAVYVFGKDMDVAKGIINQIQSGDAQVNGVMLHAFSPYLPFG 428 Query: 459 GYKKSGFGRENGRVTIEYYSQLKTVCV 485 G SG G +G + ++ K+V + Sbjct: 429 GIGASGMGEYHGHFSYLTFTHKKSVRI 455 >4IDS-A nrPDB Length = 563 Score = 322 bits (825), Expect = 3e-88, Method: Composition-based stats. Identities = 99/438 (22%), Positives = 183/438 (41%), Gaps = 26/438 (5%) Query: 65 WSQKSGMERCRILLEAARIIR-EREDEIATMECINNGKSIFEARLD-IDISWQCLEYYAG 122 W+ ER + L AA ++ ++IA + KS+++A +D + + Sbjct: 115 WAALPFDERAAVFLRAADLLAGPWREKIAAATMLGQSKSVYQAEIDAVCELIDFWRFNVA 174 Query: 123 LAASMAGEHIQLPGGSFGYTRREPL-GVCVGIGAWNYPFQIASWKSAPALACGNAMVFKP 181 A + + G + PL G I +N+ + +APAL GN +++KP Sbjct: 175 FARQILEQQPISGPGEWNRIDYRPLDGFVYAITPFNFTSIAGNLPTAPAL-MGNTVIWKP 233 Query: 182 SPFTPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKI 240 S ++A L ++ AG+PPG+ N+V G G A P +A + FTGS T + Sbjct: 234 SITQTLAAYLTMQLLEAAGLPPGVINLVTGDGFAVSDVALADPRLAGIHFTGSTATFGHL 293 Query: 241 MEMSAKGIKP------VTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRV 294 + I + E GGK ++ + + + F QGQ C +R Sbjct: 294 WQWVGTNIGRYHSYPRLVGETGGKDFVVAHASARPDVLRTALIRGAFDYQGQKCSAVSRA 353 Query: 295 FVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGA-KV 353 F+ + + +E++ + ++ GD G LI++ + + ++ AK A V Sbjct: 354 FIAHSVWQRMGDELLAKAAELRYGDITDLSNYGGALIDQRAFVKNVDAIERAKGAAAVTV 413 Query: 354 LCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTE--AEVLER 411 GG+ E GY++RP VL + E FGP++S+ + E ++L+ Sbjct: 414 AVGGEYDDSE------GYFVRPTVLLSDDPTDESFVIEYFGPLLSVHVYPDERYEQILDV 467 Query: 412 AN-DTTFGLAAGVFTRDIQRAHRVVAELQ--AGTCFINNYNVSPV--ELPFGGYKKSGFG 466 + + + L V D Q + L+ AG ++N+ V PFGG + S Sbjct: 468 IDTGSRYALTGAVIADDRQAVLTALDRLRFAAGNFYVNDKPTGAVVGRQPFGGARGSDTN 527 Query: 467 -RENGRVTIEYYSQLKTV 483 + + + ++ +++ Sbjct: 528 DKAGSPLNLLRWTSARSI 545 >5NNO-A nrPDB Length = 546 Score = 309 bits (791), Expect = 2e-84, Method: Composition-based stats. Identities = 110/457 (24%), Positives = 189/457 (41%), Gaps = 44/457 (9%) Query: 55 VQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEA-------- 106 V + AF + + +R ++L ++ E DE + + E Sbjct: 21 VSKCREAFNDDANRDLKKRKQVLRSLLNLVEENTDEFCKAIHRDRRRHRDETVVMEILPL 80 Query: 107 RLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWK 166 R ++ + ++ Y L Y EPLGV + IG WNYP + Sbjct: 81 RNEVWHLIEHMDEYVKPVKPTMEGAAALDDCELQY---EPLGVVLVIGTWNYPLLLILQP 137 Query: 167 SAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVA 226 ALA GN V KPS P +A LL ++ + V + +V GG + + + Sbjct: 138 LLGALAAGNTAVIKPSELAPATAELLTKLLPKY-VSSDVVGIVNGGVSETTAVLK-ERFD 195 Query: 227 KVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDC--DMNNAVKGALMANFLTQ 284 + +TGS +M +AK + PVTLELGGKSP+++ C +M + + + Sbjct: 196 HILYTGSARVAEIVMAAAAKHLTPVTLELGGKSPVVVDDTCADNMKVVAERIMWGKIINA 255 Query: 285 GQVCCNGTRVFVQKEILDKFTEEVVKQTQR---------------IKIGDPLLEDTRMGP 329 GQ V V+K + + + + + +K LE++ Sbjct: 256 GQTSIAPDYVVVEKSMESVLVDALAEARKAMLGDKFLKVLKGELLVKQKQQFLEESDYPR 315 Query: 330 LINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVK 389 ++N H +R++ F+ +G KV GG+ + P +LTN ++ Sbjct: 316 IVNASHFQRLMEFM-----KGGKVAVGGEADEATLT-------IAPTILTNIDPTHPVMQ 363 Query: 390 EEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGT--CFINN 447 EEIFGP++ +L+++ E ++L+ N LA VF+ + + V + +G Sbjct: 364 EEIFGPILPVLTYENEKDILKIINSREKPLALYVFSNNKRFIRGVESRTSSGAVVVNDVV 423 Query: 448 YNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVC 484 + LPFGG +SG G +GR + E +S + V Sbjct: 424 VHAGADGLPFGGVGRSGMGAYHGRYSFETFSHRRPVM 460 >2Y53-A nrPDB Length = 534 Score = 267 bits (682), Expect = 1e-71, Method: Composition-based stats. Identities = 102/464 (21%), Positives = 187/464 (40%), Gaps = 35/464 (7%) Query: 4 GTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA-AF 62 G+ + N+ G + A T +P TG + + G ++ A A+ Sbjct: 1 GSHMTELLKNHVAGQWIAGTGAGITLT--DPVTGVALVRVSSEGL-DLARAFSFAREDGG 57 Query: 63 KIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAG 122 + +R L + ++++ + + + N+G + ++ +DID L YYA Sbjct: 58 AALRALTYAQRAARLADIVKLLQAKRGDYYAIATANSGTTRNDSAVDIDGGIFTLSYYAK 117 Query: 123 LAASMAGEHIQLPGGSFGYTRREPL----------GVCVGIGAWNYPFQIASWKSAPALA 172 L AS+ H G + ++ GV + I A+N+P K+APAL Sbjct: 118 LGASLGEVHALRDGSAESLSKDRSFSAQHVLSPTRGVALFINAFNFPSWGLWEKAAPALL 177 Query: 173 CGNAMVFKPSPFTP-VSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFT 231 G ++ KP+ T ++ ++A++ +PPG +++ G +A L Q VSFT Sbjct: 178 SGVPVIVKPATATAWLTQRMVADVVDAGILPPGALSIICGSSA--GLLDQIRSFDVVSFT 235 Query: 232 GSVPTGMKIMEMSA--KGIKPVTLELGGKSPLIIFSDCDMNNAV-----KGALMANFLTQ 284 GS T + A + + ++ + I+ +D + K + + Sbjct: 236 GSADTAATLRAHPAFVQRGARLNVQADSLNSAILCADATPDTPAFDLFIKEVVREMTVKS 295 Query: 285 GQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVK 344 GQ C R FV + L+ E + + +I +G+P + RMG L++R E VL + Sbjct: 296 GQKCTAIRRAFVPEAALEPVLEALKAKLAKITVGNPRNDAVRMGSLVSREQYENVLAGIA 355 Query: 345 VAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVL-TNCRDDMTCVKE-EIFGPVMSILSF 402 +E+ A + D + P + N D+ T + + E+FGPV S+ + Sbjct: 356 ALREE-AVLAYDSSAVPLIDADANIAACVAPHLFVVNDPDNATLLHDVEVFGPVASVAPY 414 Query: 403 DT--------EAEVLERANDTTFGLAAGVFTRDIQRAHRVVAEL 438 EA + A L A +++ D R+ EL Sbjct: 415 RVTTDTNALPEAHAVALARRGQGSLVASIYSNDDAHLGRLALEL 458 >3V4C-A nrPDB Length = 528 Score = 252 bits (643), Expect = 3e-67, Method: Composition-based stats. Identities = 106/470 (22%), Positives = 170/470 (36%), Gaps = 54/470 (11%) Query: 12 LNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGM 71 + G ++ A + A PA F + VN A + A+ AF + S Sbjct: 31 KHLVAGEWLDGAGTFASAPAHGPA-----HDFAVGTVELVNRACEAAEEAFWTYGYSSRK 85 Query: 72 ERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAAS----- 126 ER L A I R + I + G + + L +A Sbjct: 86 ERAAFLRAIADEIEARAEAITEIGSQETGLPEARLNGERGRTTGQLRLFADHIEKGDYLD 145 Query: 127 -----MAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPF--QIASWKSAPALACGNAMVF 179 E P +R P+G GA N+P A +A ALA G +V Sbjct: 146 RRVDAAMPERQPAPRQEIRLVQR-PVGPVAVFGASNFPLAFSTAGGDTAAALAAGCPVVV 204 Query: 180 KPSPFTPVSALLLAEIYSEA----GVPPGLFNVVQGG-AATGQFLCQHPDVAKVSFTGSV 234 K P + ++AE A GV PG+F+++QGG G L QHP + V FTGS+ Sbjct: 205 KGHSAHPGTGEIVAEAVDAAIRKTGVHPGVFSLIQGGSRDVGHALVQHPHIKAVGFTGSL 264 Query: 235 PTGMKIMEMSAKGIKPVTL--ELGGKSPLIIFSDCDMNNAV---KGALMANFLTQGQVCC 289 G + ++ A +P+ ELG +P+ + + A +G + + GQ C Sbjct: 265 AGGRALFDLCAARPEPIPFFGELGSVNPMFLLPEALKARAETLGQGWAGSLTMGAGQFCT 324 Query: 290 NGT-RVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKE 348 N V ++ D+FT V+ ++ P G K ++ Sbjct: 325 NPGIAVVIEGADADRFTTAAVEALAKV-----------------APQTMLTDGIAKAYRD 367 Query: 349 QGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDM---TCVKEEIFGPVMSILSFDTE 405 A+ + P G P + + EE+FGP+ ++ + Sbjct: 368 GQARFATRNAVK-PLLATESSGRDASPNLFETTGAQFLADHALGEEVFGPLGLVVRVGSP 426 Query: 406 AEVLERANDTTFGLAAGVFTR--DIQRAHRV--VAELQAGTCFINNYNVS 451 AE+ E A L A + D++ A R+ V E +AG +N + Sbjct: 427 AEMEELARGFQGQLTATIHMDAGDLETARRLRPVLERKAGRVLVNGFPTG 476 >6D97-A nrPDB Length = 547 Score = 244 bits (623), Expect = 7e-65, Method: Composition-based stats. Identities = 95/473 (20%), Positives = 162/473 (34%), Gaps = 34/473 (7%) Query: 9 SQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQK 68 ++ N+ G+ A+ + +P G E+ +++ K Sbjct: 43 AEVQNFVQGSWTASANWNW---IVDPLNGDKFIKVAEVQGTEIKSFMESLSKCPKHGLHN 99 Query: 69 S--GMER----CRILLEAARIIRERE--DEIATMECINNGKSIFEARLDIDISWQCLEYY 120 ER I +AA ++ + D A + + KS +A ++ +S + LE + Sbjct: 100 PLKAPERYLMYGDISAKAAHMLGQPTVLDFFAKLIQRVSPKSYQQALAEVQVSQKFLENF 159 Query: 121 AGLAASMAGEHIQLPGGSFGYT---RREPLGVCVGIGAWNYPFQIASWKSAPALACGNAM 177 G +PG G R P G I +N+P +I + AL GN Sbjct: 160 CGDQVRFLARSFAVPGNHLGQRSNGYRWPYGPVAIITPFNFPLEIPLLQLMGALYMGNKP 219 Query: 178 VFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTG 237 V K + + + + G+P + + A L + FTGS Sbjct: 220 VLKVDSKVSIVMEQMIRLLHDCGLPAEDMDFINSDGAVMNKLLLEANPKMTLFTGSSRVA 279 Query: 238 MKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMA-NFLTQGQVCCNGTRVFV 296 K+ +A V LE G I+ D + V + GQ C + +F+ Sbjct: 280 EKL---AADLKGRVKLEDAGFDWKILGPDVQEVDYVAWVCDQDAYACSGQKCSAQSVLFM 336 Query: 297 QKEILDK-FTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLC 355 K E++ K ++R K+ ED +GP++ + + K +G+KVL Sbjct: 337 HKNWSSSGLLEKMKKLSERRKL-----EDLTIGPVLTVTTEAMIEHMNNLLKIRGSKVLF 391 Query: 356 GGDIYVPEDPKLKDGYYMRPCVLTNCRD-----DMTCVKEEIFGPVMSILSF--DTEAEV 408 GG+ G V + + V +EIFGP + + D V Sbjct: 392 GGEPLANHSIPKIYGAMKPTAVFVPLEEILKSGNFELVTKEIFGPFQVVTEYSEDQLELV 451 Query: 409 LERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCF--INNYNVSPVE-LPFG 458 LE L A + + D V+ GT + I + FG Sbjct: 452 LEACERMNAHLTAAIVSNDPLFLQDVLGRSVNGTTYAGIRARTTGAPQNHWFG 504 >5J7I-A nrPDB Length = 488 Score = 202 bits (515), Expect = 3e-52, Method: Composition-based stats. Identities = 86/440 (19%), Positives = 153/440 (34%), Gaps = 44/440 (10%) Query: 38 RVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECI 97 ++ +EV ++ AKAA KI + + E +I+ A RE +A M Sbjct: 23 SMLRDIDLQSIQEVRNYLEEAKAAQKILEKMTQSEIDKIVESMANAAREEAGRLAAMAVE 82 Query: 98 NNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWN 157 G E + ++ + Y + I+ + + +P+G+ GI Sbjct: 83 ETGFGNVEDKTLKNLFAAN-DVYNSIKDVKTVGIIRRDEENRVWEIAQPVGIVAGIIPST 141 Query: 158 YPFQIASWKSAPALACGNAMVFKPSPF----TPVSALLLAEIYSEAGVPPGLFN-VVQGG 212 P +K+ A+ NA+VF P P T +A ++ E AG P GL + + Q Sbjct: 142 NPTSTVIFKALIAVKARNAIVFSPHPSAAKCTAEAARIMQEAAERAGAPKGLISCITQPT 201 Query: 213 AATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNA 272 A L +H + TG G +++ + KP G P+ I ++ A Sbjct: 202 MAATNELMKHKLTDVILATG----GPGLVKAAYSSGKPAYGVGPGNVPVYIHESANIAKA 257 Query: 273 VKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLIN 332 V+ + + G +C + + V + I +K E+ +Q +N Sbjct: 258 VQLIIQSKTFDYGTICASEQALLVDESIKEKVVAELKQQGAY---------------FLN 302 Query: 333 RPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEI 392 ++V + V AK++ P+ G + V ++ KE Sbjct: 303 EEEKQKVASIIMVNGSLNAKIV----GKAPQVIAEMAGIEIPSDVKLLVAEETEVGKEYP 358 Query: 393 F-----GPVMSILSFDTEAEVLERANDT--TFGL--AAGVFTRDIQRAHRVVAELQAGTC 443 F P+++ E E A GL G+ D + + AG Sbjct: 359 FSIEKLSPILAFYIVKGMEEASELAQKLLEVGGLGHTVGIHAEDEKVIEAYTIDKPAGRI 418 Query: 444 FINNYNVSPVELPFGGYKKS 463 +N FGG + Sbjct: 419 VVNAGTT------FGGIGAT 432 >1EZ0-A nrPDB Length = 510 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 95/468 (20%), Positives = 171/468 (36%), Gaps = 51/468 (10%) Query: 24 DASGTEKAFEPATGRVI-ATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAAR 82 A TG + F E EVN A A + + + + +R +L A Sbjct: 4 QTDNVFYATNAFTGEALPLAFPVHTEVEVNQAATAAAKVARDFRRLNNSKRASLLRTIAS 63 Query: 83 IIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGL--AASMAGEHIQLPGGSFG 140 + R D+I + +I + L +A + + S + P + Sbjct: 64 ELEARSDDIIARAHLETALPEVRLTGEIARTANQLRLFADVVNSGSYHQAILDTPNPTRA 123 Query: 141 -----YTRRE--PLGVCVGIGAWNYPF--QIASWKSAPALACGNAMVFKPSPFTPVSALL 191 RR+ LG GA N+P A +A ALA G ++ K P ++ + Sbjct: 124 PLPKPDIRRQQIALGPVAVFGASNFPLAFSAAGGDTASALAAGCPVIVKGHTAHPGTSQI 183 Query: 192 LAEIYSEA----GVPPGLFNVVQGG-AATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK 246 +AE +A +P +F ++QG A GQ L HP++ V FTGSV G + ++ + Sbjct: 184 VAECIEQALKQEQLPQAIFTLLQGNQRALGQALVSHPEIKAVGFTGSVGGGRALFNLAHE 243 Query: 247 GIKPVTL--ELGGKSPLIIFSDCDMNNA--VKGALMANFLTQGQVCCNGTRVFV----QK 298 +P+ ELG +P IF A + + + GQ C VF + Sbjct: 244 RPEPIPFYGELGAINPTFIFPSAMRAKADLADQFVASMTMGCGQFCTKPGVVFALNTPET 303 Query: 299 EILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGD 358 + + + +++Q + P + D+ +++R + + A Sbjct: 304 QAFIETAQSLIRQQSPSTLLTPGIRDSYQSQVVSRGSDDGIDVTFSQA------------ 351 Query: 359 IYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFG 418 E P + ++ + +EEIFGP I+ + A++L + Sbjct: 352 ----ESPCVASALFVTS---SENWRKHPAWEEEIFGPQSLIVVCENVADMLSLSEMLAGS 404 Query: 419 LAAGVFTR--DIQRAHRVVAELQ--AGTCFINNYNVS---PVELPFGG 459 L A + D + +++ L+ AG N + + GG Sbjct: 405 LTATIHATEEDYPQVSQLIPRLEEIAGRLVFNGWPTGVEVGYAMVHGG 452 >5UJU-A nrPDB Length = 576 Score = 187 bits (475), Expect = 1e-47, Method: Composition-based stats. Identities = 94/493 (19%), Positives = 165/493 (33%), Gaps = 72/493 (14%) Query: 16 GGARVEPADASGTEKAFEPATGRVIA--TFTCSGEKEV-------NLAVQNAKAAFKIWS 66 G + T + +PA+G + ++ + + A AA + W Sbjct: 53 DGEAAFKSHLGKTFELDQPASGETVGAERSPYGVALDIRYPKSTPDALIAAAAAAQRTWR 112 Query: 67 QKSGMERCRILLEAARIIREREDEIAT----------MECINNGKSIFEARLD--IDISW 114 + + LE + EIA M G + R + +W Sbjct: 113 EAGPSAWIGVSLEILARLNRASFEIAYSVMHTTGQAFMMAFQAGGPHAQDRALEAVAYAW 172 Query: 115 QCLEY--YAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPAL- 171 L G++ L P G + +G +P +W P L Sbjct: 173 DQLRRIPADAHWEKPQGKNPPLAMQKRYTIV--PRGTGLVLGCCTFP----TWNGYPGLF 226 Query: 172 ---ACGNAMVFKPSPFT----PVSALLLAEIYSEAGVPPGLFNVV---QGGAATGQFLCQ 221 A GN ++ KP P ++ + ++ EAG P + ++ A Q L Sbjct: 227 ADLATGNTVIVKPHPGAILPLAITVRIARDVLREAGFDPNVVTLLATEPNDGALVQDLAL 286 Query: 222 HPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANF 281 P++ + FTGS G + + + V E G + ++I S D+ A K + Sbjct: 287 RPEIKLIDFTGSTQNGTWLERHAHQA--QVYTEKAGVNQIVIDSTDDLKAAAKNIAFSLA 344 Query: 282 LTQGQVCCNGTRVFVQK---------EILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLIN 332 L GQ+C ++V + D+ + + Q++ GDP +G + Sbjct: 345 LYSGQMCTAPQNIYVPRDGIRTADGHASFDEVAQAIAGAVQKLT-GDPARSVELIGAI-- 401 Query: 333 RPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEI 392 + V + A+ G +L D + P D P VL D +E Sbjct: 402 --QNDGVTARIDAARAVGRVLL---DSQTLQHPAFPDARVRTPLVLQLDVADREKFTQEW 456 Query: 393 FGPVMSILSFDTEAEVLERANDT---TFGLAAGVFT--RD-IQRAHRVVAELQA------ 440 FGP+ +++ D+ A+ L+ A + L V++ D I AH Sbjct: 457 FGPISFVIATDSTAQSLDLAGEIAAEHGALTLSVYSTADDVIDAAHEAAVRGGVALSINL 516 Query: 441 -GTCFINNYNVSP 452 G F+N Sbjct: 517 TGGVFVNQSAAFS 529 >3K9D-A nrPDB Length = 464 Score = 170 bits (432), Expect = 9e-43, Method: Composition-based stats. Identities = 76/434 (17%), Positives = 147/434 (33%), Gaps = 49/434 (11%) Query: 47 GEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEA 106 +EV +++A A K + S + I+ A +++A M G I++ Sbjct: 10 SIQEVRNLIESANKAQKELAAMSQQQIDTIVKAIADAGYGAREKLAKMAHEETGFGIWQD 69 Query: 107 RLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWK 166 ++ I + Y + ++ PLGV G+ P +K Sbjct: 70 KV-IKNVFASKHVYNYIKDMKTIGMLKEDNEKKVMEVAVPLGVVAGLIPSTNPTSTVIYK 128 Query: 167 SAPALACGNAMVFKPSPFTP----VSALLLAEIYSEAGVPPGLFNVVQ-GGAATGQFLCQ 221 + ++ GN++VF P P + +++E +AG P G + + L + Sbjct: 129 TLISIKAGNSIVFSPHPNALKAILETVRIISEAAEKAGCPKGAISCMTVPTIQGTDQLMK 188 Query: 222 HPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANF 281 H D A + TG G +++ + P G P I ++ AVK L + Sbjct: 189 HKDTAVILATG----GSAMVKAAYSSGTPAIGVGPGNGPAFIERSANIPRAVKHILDSKT 244 Query: 282 LTQGQVCCNGTRVFVQKEILDKFTEEVVKQ-------TQRIKIGD-PLLEDTRMGPLINR 333 G +C + V V++ + E KQ + +++G L + M P I Sbjct: 245 FDNGTICASEQSVVVERVNKEAVIAEFRKQGAHFLSDAEAVQLGKFILRPNGSMNPAIVG 304 Query: 334 PHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIF 393 ++ + + A+VL + K G + E Sbjct: 305 KSVQHIANLAGLTVPADARVL--------IAEETKVGAKIP-------------YSREKL 343 Query: 394 GPVMSILSFDTEAEVLERANDTTFGLAAG----VFTRDIQRAHRVVAELQAGTCFINNYN 449 P+++ + +T E E + D + AG + + D + + +N Sbjct: 344 APILAFYTAETWQEACELSMDILYHEGAGHTLIIHSEDKEIIREFALKKPVSRLLVNTPG 403 Query: 450 VSPVELPFGGYKKS 463 GG + Sbjct: 404 AL------GGIGAT 411 >3MY7-A nrPDB Length = 452 Score = 168 bits (427), Expect = 3e-42, Method: Composition-based stats. Identities = 78/432 (18%), Positives = 148/432 (34%), Gaps = 36/432 (8%) Query: 43 FTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKS 102 + E++ + K A + ++ S + +I A+ + +A +G Sbjct: 1 MPVTNMAELDAMIARVKKAQEEFATYSQEQVDKIFRAASLAANQARIPLAQQAVEESGMG 60 Query: 103 IFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQI 162 I E ++ + Y ++ T EP+G+ GI P Sbjct: 61 IVEDKVIKNHFASEF-IYNKYKDEQTCGILEEDDNLGTMTIAEPVGIICGIVPTTNPTST 119 Query: 163 ASWKSAPALACGNAMVFKPSPF----TPVSALLLAEIYSEAGVPPGLFNVV-QGGAATGQ 217 A +KS +L N ++F P P T +A L+ + AG P + + Q Sbjct: 120 AIFKSLISLKTRNGIIFSPHPRAKNSTNDAAKLVLDAAVAAGAPKDIIGWIDQPSVELSN 179 Query: 218 FLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGAL 277 L +H D+A + TG G +++ + KP G P++I D+ AV L Sbjct: 180 ALMKHDDIALILATG----GPGMVKAAYSSGKPAIGVGAGNVPVVIDETADIKRAVASVL 235 Query: 278 MANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLE 337 M+ G VC + V V E+ D+ E + + ++ LI+ Sbjct: 236 MSKTFDNGVVCASEQAVIVVDEVYDEVKERFASHKAHVLSKTDADKVRKV-LLIDGALNA 294 Query: 338 RVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVM 397 +++G A + + G + + +G L D E++ P + Sbjct: 295 KIVGQPATAIAE----MAGVKVPADTKVLIGEG-------LGKVSYDDAFAHEKL-SPTL 342 Query: 398 SILSFDTEAEVLERANDTT----FGLAAGVFTR---DIQRAHRVVAELQAGTCFINNYNV 450 + D + + +A G +G++T + R +++ IN Sbjct: 343 GMFRADNFEDAVAQAVTMVEIGGIGHTSGLYTNQDVNADRIRYFGDKMKTARILINIPTT 402 Query: 451 SPVELPFGGYKK 462 GG Sbjct: 403 ------HGGIGD 408 >5DBV-A nrPDB Length = 445 Score = 159 bits (403), Expect = 2e-39, Method: Composition-based stats. Identities = 69/452 (15%), Positives = 148/452 (32%), Gaps = 44/452 (9%) Query: 49 KEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARL 108 ++N A++ AK A + + S +R +I+ + E + +A M G Sbjct: 16 DDMNQAIEAAKEAQLVVKKMSMDQREKIISAIRKKTIEHAETLARMAVEETG------MG 69 Query: 109 DIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRRE--PLGVCVGIGAWNYPFQIASWK 166 ++ + A G G T E P GV I P + Sbjct: 70 NVGHKILKHQLVAEKTPGTEDITTTAWSGDRGLTLVEMGPFGVIGAITPCTNPSETIICN 129 Query: 167 SAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPG-----LFNVVQGGAATGQFLCQ 221 + LA GN +VF P P ++ ++ +EA + G +V + + + + Sbjct: 130 TIGMLAGGNTVVFNPHPAAIKTSNFAVQLINEASLSAGGPVNIACSVRKPTLDSSKIMMS 189 Query: 222 HPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANF 281 H D+ ++ TG G ++ + K G P+++ D+ A + + Sbjct: 190 HQDIPLIAATG----GPGVVTAVLQSGKRGIGAGAGNPPVLVDETADIRKAAEDIINGCT 245 Query: 282 LTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLG 341 V I ++ +VK + I + E++ Sbjct: 246 FDNNLPAIAEKEVVAIDAIANELMNYMVK-----------EQGCYA---ITKEQQEKLTN 291 Query: 342 FVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILS 401 V K + + + +R + + + EE+ P++ I+ Sbjct: 292 LVITPKGLNRNCVGKDARTLLGMIGIDVPSNIRCIIFEG-EKEHPLISEELMMPILGIVR 350 Query: 402 FDTEAEVLERANDTTFGL--AAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGG 459 + + +E+A G +A + ++++ R + N + + + FGG Sbjct: 351 AKSFDDAVEKAVWLEHGNRHSAHIHSKNVDRITTYAKAIDTAILVKNAPSYAAIG--FGG 408 Query: 460 YK------KSGFGRENGRVTIEYYSQLKTVCV 485 S G G + +++ + + Sbjct: 409 EGFCTFTIASRTG--EGLTSASTFTKRRRCVM 438 >5JFN-A nrPDB Length = 524 Score = 133 bits (336), Expect = 1e-31, Method: Composition-based stats. Identities = 73/433 (16%), Positives = 146/433 (33%), Gaps = 43/433 (9%) Query: 69 SGMERCRILLEAARII--REREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAAS 126 S +R R + +I ++ ++++ M G +E +L + Sbjct: 112 SMSDRARFVQGIRDVILNQDTLEKMSRMAVEETGMGNYEHKLIKNRLAG------EKTPG 165 Query: 127 MAGEHIQLPGGSFGYTRRE--PLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPF 184 + G G T E P GV I P + S LA GN++VF P P Sbjct: 166 IEDLTTDAFSGDNGLTLVEYSPFGVIGAITPTTNPTETIVCNSIGMLAAGNSVVFSPHPR 225 Query: 185 TPVSALLLAEI----YSEAGVPPG-LFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMK 239 +LLL + + G P + V + + HP V + TG G Sbjct: 226 ARQVSLLLVRLINQKLAALGAPENLVVTVEKPSIENTNAMMAHPKVRMLVATG----GPA 281 Query: 240 IMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKE 299 I++ K G P+++ ++ A + + + Sbjct: 282 IVKAVLSTGKKAIGAGAGNPPVVVDETANIEKAACDIVNGCSFDNNLPXVAEKEIIAVAQ 341 Query: 300 ILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDI 359 I D + K +I DP + L+++ V AK G + C G Sbjct: 342 IADYLIFNLKKN-GAYEIKDPAV-------------LQQLQDLVLTAKG-GPQTKCVGKS 386 Query: 360 YVPEDPKLKDGYYMR-PCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFG 418 V ++ +L + V+EE+ P++ ++ +T + ++ A + Sbjct: 387 AVWLLSQIGISVDASIKIILMEVPREHPFVQEELMMPILPLVRVETVDDAIDLAIEVEHD 446 Query: 419 L--AAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGREN----GRV 472 A + + D+++ ++ +Q N + + + GG S F G Sbjct: 447 NRHTAIMHSTDVRKLTKMAKLIQTTIFVKNGPSYAGLGA--GGEGYSTFTIAGPTGEGLT 504 Query: 473 TIEYYSQLKTVCV 485 + + +++ + + Sbjct: 505 SAKSFARRRKCVM 517 >1O20-A nrPDB Length = 427 Score = 110 bits (275), Expect = 2e-24, Method: Composition-based stats. Identities = 78/473 (16%), Positives = 144/473 (30%), Gaps = 103/473 (21%) Query: 51 VNLAVQNAKAAFKIW---SQKSGMERCRILLEAARIIREREDEIATMECINNGK----SI 103 ++ ++ AK + W + E+ + + + A + ER EI I+ K + Sbjct: 13 MDELLEKAKKVREAWDVLRNATTREKNKAIKKIAEKLDERRKEILEANRIDVEKARERGV 72 Query: 104 FEARLD--------IDISWQCLEYYAGLAASMAGEHIQ---LPGGSFGYTRREPLGVCVG 152 E+ +D ID + E GL + GE I G R P+G Sbjct: 73 KESLVDRLALNDKRIDEMIKACETVIGLKDPV-GEVIDSWVREDGLRIARVRVPIGPIGI 131 Query: 153 I---GAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEA----GVPPGL 205 I + + AL GN ++ + S + EA +P Sbjct: 132 IYESRP-----NVTVETTILALKSGNTILLRGGSDALNSNKAIVSAIREALKETEIPESS 186 Query: 206 FNVVQGGAA--TGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELG-GKSPLI 262 ++ + + ++ V G ++ LE G G + Sbjct: 187 VEFIENTDRSLVLEMIRLREYLSLVI----PRGGYGLISFVRDNATVPVLETGVGNCHIF 242 Query: 263 IFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLL 322 + D+ AV + A G C ++ V ++I +F Sbjct: 243 VDESADLKKAVPVIINAKTQRPG-TCNAAEKLLVHEKIAKEFL----------------- 284 Query: 323 EDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCR 382 P+I V+ ++ G +V + + P V+ Sbjct: 285 ------PVI-----------VEELRKHGVEV-----------RGCEKTREIVPDVVPATE 316 Query: 383 DDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGT 442 DD E +++I E +E + G + + T + A + V+E+ A Sbjct: 317 DD---WPTEYLDLIIAIKVVKNVDEAIEHIKKYSTGHSESILTENYSNAKKFVSEIDAAA 373 Query: 443 CFINNYNVSPVELPFGGYKKSGFGRE----------NGRVTIEYYSQLKTVCV 485 ++N F GFG E G V + + K V + Sbjct: 374 VYVNASTRFTDGGQF------GFGAEIGISTQRFHARGPVGLRELTTYKFVVL 420 >4JBE-A nrPDB Length = 445 Score = 93.0 bits (230), Expect = 3e-19, Method: Composition-based stats. Identities = 84/475 (17%), Positives = 135/475 (28%), Gaps = 98/475 (20%) Query: 19 RVEPADASGTEKAF---EPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCR 75 P GTE + T V K V + AK+A S Sbjct: 14 WSHPQFEKGTENLYFQSNAMTNEV--------AKAVEECARAAKSAAPSLSGAPDTAIDA 65 Query: 76 ILLEAARIIREREDEIATMECINNGK--------------SIFEARLDIDISWQCLEYYA 121 L A + D + + K +I E+R + L A Sbjct: 66 ALESMADRLLAHRDAVLAANAEDIAKAEAGGMSAGLLDRLTITESR--LTDMADQLRLLA 123 Query: 122 GLAA-SMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPF--QIASWKSAPALACGNAMV 178 G E L GG RR P+GV NY + ++ + NA V Sbjct: 124 GAPHPQRTVELSTLDGGLRLVERRRPVGVIGA----NYEARPNVTVDVASQLVKSRNAGV 179 Query: 179 FKPSPFTPVSALLLAEI-----YSEAGVPPGLFNVVQ-GGAATGQFLCQHPD-VAKVSFT 231 + SA L E+ +++G+ + +V L + PD V V Sbjct: 180 LRTGSAALKSAQRLLEVVIRPALTDSGIDANVVQLVPRPEREAAGALVRLPDLVPLVILR 239 Query: 232 GSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNG 291 GS + + +A+ G L + D + V+ ++ + G VC Sbjct: 240 GSGESTRALALEAAQHGVRTLAHADGGGVLYVDEKADRD-TVRSLVVNSLDRLG-VCNRL 297 Query: 292 TRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGA 351 + + + ++F P+++ ER Sbjct: 298 NLLLIHDAVYEEFW-----------------------PVVSEALAER------------- 321 Query: 352 KVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLER 411 G GY + + T ++ D AE + Sbjct: 322 -----GVSPSLPPYDHPIGYEWA----LDSEREATV----------TVARVDGVAEAVRI 362 Query: 412 ANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFG 466 AN+ T GLAAG+ T D + A Q F N G ++G Sbjct: 363 ANEETSGLAAGIATEDARAAEEFFDGYQGTGVFWNAPTRLLDGFKLLGVPETGIN 417 >4GHK-A nrPDB Length = 444 Score = 88.4 bits (218), Expect = 6e-18, Method: Composition-based stats. Identities = 84/446 (18%), Positives = 136/446 (30%), Gaps = 87/446 (19%) Query: 75 RILLEAARIIREREDEIATMECINNG----KSIFEARLD--------IDISWQCLEYYAG 122 L AR I + + K + A +D + + L A Sbjct: 52 AALEAVARAIERDAGALKAANARDVARAKDKGLDAAFVDRLTLSDKALKTMVEGLRQVAT 111 Query: 123 LAASMAGEHIQL---PGGSFGYTRREPLGVCVGI---GAWNYPFQIASWKSAPALACGNA 176 L + GE L P G R PLGV I + +A L GNA Sbjct: 112 LPDPI-GEMSNLKYRPSGIQVGQMRVPLGVIGIIYESRP-----NVTIDAAALCLKSGNA 165 Query: 177 MVFKPSPFTPVSALLLAEI----YSEAGVPPGLFNVVQGG--AATGQFLCQHPDVAKVSF 230 + + S LA++ +EAG+P VV+ AA G+ + V + Sbjct: 166 TILRGGSEALESNTALAKLIGEGLAEAGLPQDTVQVVETADRAAVGRLITMTEYVDVIV- 224 Query: 231 TGSVPTGMKIMEMSAKGIK-PVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCC 289 G ++E + P+ L G + + + A+ A G C Sbjct: 225 ---PRGGKSLIERLINEARVPMIKHLDGICHVYVDDRASVTKALTVCDNAKTHRYG-TCN 280 Query: 290 NGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQ 349 + V + I + G L +E + A + Sbjct: 281 TMETLLVARGIAPAVLSPL-------------------GRLYREKGVELRVDADARAVLE 321 Query: 350 GAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVL 409 A V P L + D+ + E PV++I D + Sbjct: 322 AAGV--------------------GP--LVDATDED--WRTEYLAPVLAIKIVDGIDAAI 357 Query: 410 ERANDTTFGL--AAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGR 467 E N +G + T D RA R + E+ + + +N FG + G Sbjct: 358 EHIN--EYGSHHTDAIVTEDHDRAMRFLREVDSASVMVNASTRFADGFEFGLGAEIGISN 415 Query: 468 EN----GRVTIEYYSQLKTVCVEMGD 489 + G V +E + LK V + G+ Sbjct: 416 DKLHARGPVGLEGLTSLKYVVLGHGE 441 >1VLU-A nrPDB Length = 468 Score = 71.8 bits (175), Expect = 7e-13, Method: Composition-based stats. Identities = 70/448 (15%), Positives = 135/448 (30%), Gaps = 88/448 (19%) Query: 56 QNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATM------ECINNG------KSI 103 +NA+ A I S R IL + ++ I G K + Sbjct: 21 KNARKAGNILKTISNEGRSDILYKIHDALKANAHAIEEANKIDLAVAKETGLADSLLKRL 80 Query: 104 FEARLDI-DISWQCLEYYAGLAASMAGEHI--QLPGGSFGYTRREPLGVCVGIGAWNYPF 160 + D ++ Q ++ A L + + +L G Y P+GV + I + Sbjct: 81 DLFKGDKFEVMLQGIKDVAELEDPVGKVKMARELDDGLTLYQVTAPVGVLLVI--FESRP 138 Query: 161 QIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIY--------SEAGVPPGLFNVVQGG 212 ++ + +A ++ GNA + K + + +A+I SE GVP G +++ Sbjct: 139 EVIANITALSIKSGNAAILKGGKESVNTFREMAKIVNDTIAQFQSETGVPVGSVQLIETR 198 Query: 213 AATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNA 272 L Q + V GS KI + PV G + + D D+ A Sbjct: 199 QDVSDLLDQDEYIDLVVPRGSNALVRKIKDT---TKIPVLGHADGICSIYLDEDADLIKA 255 Query: 273 VKGALMANFLT-QGQVCCNGTRVFVQK--EILDKFTEEV-------VKQTQRIKIGDPLL 322 + +L A G C + + + E + + T+ +K Sbjct: 256 KRISLDAKTNYPAG--CNAMETLLINPKFSKWWEVLENLTLEGGVTIHATKDLKTAY-FD 312 Query: 323 EDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCR 382 + +G L + V + Sbjct: 313 KLNELGKLTEAIQCK--------------------------------------TVDADEE 334 Query: 383 DDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGT 442 D +E ++ + ++ N + + T + A + + + + Sbjct: 335 QD---FDKEFLSLDLAAKFVTSTESAIQHINTHSSRHTDAIVTENKANAEKFMKGVDSSG 391 Query: 443 CFINNYNVSPVELPFGGYKKSGFGRENG 470 + N G++ GFG E G Sbjct: 392 VYWNASTRFAD-----GFRY-GFGAEVG 413 >2H5G-A nrPDB Length = 463 Score = 68.7 bits (167), Expect = 5e-12, Method: Composition-based stats. Identities = 69/466 (14%), Positives = 143/466 (30%), Gaps = 100/466 (21%) Query: 51 VNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDI 110 V + A++ ++ + +R I+ A ++ ++ DEI + N K + EA + Sbjct: 31 VEQQGEMARSGGRMLATLEPEQRAEIIHHLADLLTDQRDEIL----LANKKDLEEAEGRL 86 Query: 111 DI----------------SWQCLEYYAGLAASMAGEHIQLPGGSFGYTRRE---PLGVCV 151 + + A S+ G ++ + + P+GV + Sbjct: 87 AAPLLKRLSLSTSKLNSLAIGLRQIAASSQDSV-GRVLRRTRIAKNLELEQVTVPIGVLL 145 Query: 152 GIGAWNY---PFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEA----GVPPG 204 I + P + +A A+A GN ++ K S +L + EA GV Sbjct: 146 VI----FESRPDCLP-QVAALAIASGNGLLLKGGKEAAHSNRILHLLTQEALSIHGV-KE 199 Query: 205 LFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIF 264 +V + + GS I + +AKGI PV G + + Sbjct: 200 AVQLVNTREEVEDLCRLDKMIDLIIPRGSSQLVRDI-QKAAKGI-PVMGHSEGICHMYVD 257 Query: 265 SDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLED 324 S+ ++ + + C + + ++ Sbjct: 258 SEASVDKVTRLVRDSKCEYPA-ACNALETLLIHRD------------------------- 291 Query: 325 TRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDD 384 L+ P +++ + + + + K+ G LT + Sbjct: 292 -----LLRTPLFDQI---IDMLRVEQVKIHAGPKFASY---------------LTFSPSE 328 Query: 385 MTCVKEEIFGPV-MSILSFDTEAEVLERANDTTFGLAAG--VFTRDIQRAHRVVAELQAG 441 + ++ E +G + + I D + ++ +G + + T D A + + + Sbjct: 329 VKSLRTE-YGDLELCIEVVDNVQDAIDHI--HKYGSSHTDVIVTEDENTAEFFLQHVDSA 385 Query: 442 TCFINNYNVSPVELPFG-----GYKKSGFGRENGRVTIEYYSQLKT 482 F N FG G S G V +E K Sbjct: 386 CVFWNASTRFSDGYRFGLGAEVGISTSRI-HARGPVGLEGLLTTKW 430 >5A0V-A nrPDB Length = 561 Score = 39.4 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 22/116 (18%), Positives = 42/116 (36%), Gaps = 10/116 (8%) Query: 333 RPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKD-GYY-MRPCVLTNCRDDMTCVKE 390 H+ R+ + A E G +V G V +D GY + P ++ + + Sbjct: 242 ASHVHRIQQILDAAHEYGRRVAFVGRSMVRNMGIARDLGYLKVPPGLVVDVKTLDDLPDS 301 Query: 391 EIF-------G-PVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAEL 438 E+ G P+ ++ + N T LA+ + + +RV+ L Sbjct: 302 EVVLVCTGSQGEPMAALSRMANRDHQIRIVNGDTVILASSLIPGNENAVYRVINGL 357 >1PDZ-A nrPDB Length = 434 Score = 36.0 bits (82), Expect = 0.040, Method: Composition-based stats. Identities = 23/119 (19%), Positives = 43/119 (36%), Gaps = 13/119 (10%) Query: 197 SEAGVPPGLFNVVQGGAATGQFLCQHP----DVAKVSFTGSVPTGMKIMEMSAKGIK--- 249 E +P FNV+ GG+ G L SFT ++ G ++ IK Sbjct: 141 DEVILPVPAFNVINGGSHAGNKLAMQEFMILPTGATSFTEAMRMGTEVYHHLKAVIKARF 200 Query: 250 ----PVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCC--NGTRVFVQKEILD 302 + GG +P I+ + ++ + A + + ++ + + Q I D Sbjct: 201 GLDATAVGDEGGFAPNILNNKDALDLIQEAIKKAGYTGKIEIGMDVAASEFYKQNNIYD 259 >4YIF-A nrPDB Length = 164 Score = 34.8 bits (79), Expect = 0.079, Method: Composition-based stats. Identities = 20/74 (27%), Positives = 34/74 (45%), Gaps = 11/74 (14%) Query: 23 ADASGTEKAFEPATG-RVIATFTCSGEKEVNLAVQNAKAAFKIW-----SQKSGMERCRI 76 AD ++A P G +V+ + + SG + V + A+ A + W + + ER I Sbjct: 94 ADMGFVDRAPHPIDGRQVLVSVSESGAELV----KAARRARQEWLAERLATLNRSERD-I 148 Query: 77 LLEAARIIREREDE 90 L AA ++ DE Sbjct: 149 LRSAADLMLALVDE 162 >1NNE-A nrPDB Length = 765 Score = 34.0 bits (77), Expect = 0.16, Method: Composition-based stats. Identities = 16/55 (29%), Positives = 23/55 (41%), Gaps = 1/55 (1%) Query: 71 MERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAA 125 E+ R + +IR RE+E +E K EA + L+ YA LA Sbjct: 482 KEKEREVYRLEALIRRREEE-VFLEVRERAKRQAEALREAARILAELDVYAALAE 535 >1EWR-A nrPDB Length = 649 Score = 34.0 bits (77), Expect = 0.17, Method: Composition-based stats. Identities = 16/55 (29%), Positives = 23/55 (41%), Gaps = 1/55 (1%) Query: 71 MERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAA 125 E+ R + +IR RE+E +E K EA + L+ YA LA Sbjct: 366 KEKEREVYRLEALIRRREEE-VFLEVRERAKRQAEALREAARILAELDVYAALAE 419 >3BA0-A nrPDB Length = 365 Score = 33.3 bits (75), Expect = 0.25, Method: Composition-based stats. Identities = 9/41 (21%), Positives = 21/41 (51%), Gaps = 3/41 (7%) Query: 44 TCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARII 84 ++V+ A+ + AF++WS + ++ +I A I+ Sbjct: 18 PDMNREDVDYAI---RKAFQVWSNVTPLKFSKINTGMADIL 55 >1JIZ-A nrPDB Length = 166 Score = 32.9 bits (74), Expect = 0.36, Method: Composition-based stats. Identities = 9/41 (21%), Positives = 21/41 (51%), Gaps = 3/41 (7%) Query: 44 TCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARII 84 ++V+ A+ + AF++WS + ++ +I A I+ Sbjct: 25 PDMNREDVDYAI---RKAFQVWSNVTPLKFSKINTGMADIL 62 >1V9N-A nrPDB Length = 360 Score = 32.5 bits (73), Expect = 0.43, Method: Composition-based stats. Identities = 21/134 (15%), Positives = 45/134 (33%), Gaps = 27/134 (20%) Query: 348 EQGAKVLCGGDIYVPEDPKLKDG-----YYMRPCVLTNCR--DDMTCVKEEIFGP----- 395 E+ AK++ + G Y+ + + ++E GP Sbjct: 34 EEDAKIVADNLVMADLRGVESHGVQRLKRYVDGIISGGVNLHPKIRVIRE---GPSYALI 90 Query: 396 -----VMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQR----AHRVVAELQAGTCFIN 446 + ++ + + +++A DT G+ V R+ + + + G I+ Sbjct: 91 DGDEGLGQVVGYRSMKLAIKKAKDTGIGI---VIARNSNHYGIAGYYALMAAEEGMIGIS 147 Query: 447 NYNVSPVELPFGGY 460 N P+ P GG Sbjct: 148 MTNSRPLVAPTGGI 161 >2PA6-A nrPDB Length = 427 Score = 31.7 bits (71), Expect = 0.66, Method: Composition-based stats. Identities = 17/66 (25%), Positives = 29/66 (43%), Gaps = 2/66 (3%) Query: 201 VPPGLFNVVQGGAATGQFL-CQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKS 259 +P + NV+ GG G L Q + V T S+ +++ +K V LE GK+ Sbjct: 148 MPVPMMNVINGGKHAGNDLDLQEFMIMPVGAT-SISEAVRMGSEVYHVLKNVILEKYGKN 206 Query: 260 PLIIFS 265 + + Sbjct: 207 AVNVGD 212 >3B97-A nrPDB Length = 433 Score = 31.7 bits (71), Expect = 0.73, Method: Composition-based stats. Identities = 18/72 (25%), Positives = 25/72 (34%), Gaps = 8/72 (11%) Query: 198 EAGVPPGLFNVVQGGAATGQFLCQHP----DVAKVSFTGSVPTGMKIMEMSAKGIKPVTL 253 E +P FNV+ GG+ G L V +F M+I +K V Sbjct: 141 EVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAANF----REAMRIGAEVYHNLKNVIK 196 Query: 254 ELGGKSPLIIFS 265 E GK + Sbjct: 197 EKYGKDATNVGD 208 >3LOO-A nrPDB Length = 365 Score = 31.4 bits (70), Expect = 1.0, Method: Composition-based stats. Identities = 15/49 (30%), Positives = 24/49 (48%), Gaps = 8/49 (16%) Query: 390 EEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAEL 438 EEIF P + +L F E E + A + +G T D++ + +A L Sbjct: 226 EEIF-PYVDVL-FGNETEAIALAKEFNYG------TEDLREIGKRIAAL 266 >2CUN-A nrPDB Length = 410 Score = 31.4 bits (70), Expect = 1.1, Method: Composition-based stats. Identities = 19/70 (27%), Positives = 30/70 (42%), Gaps = 7/70 (10%) Query: 328 GPLINRPHLERVLGFVKVAKEQGAKVLCG---GDIYVPEDPKLKDGYYMRPCVLTNCRDD 384 G +I+ + VL ++ E GAKV+ G G Y + ++ VL+ D Sbjct: 27 GKIISDARFKAVLPTIRYLIESGAKVVIGTHQGKPYSEDYTTTEE----HARVLSELLDQ 82 Query: 385 MTCVKEEIFG 394 E+IFG Sbjct: 83 HVEYIEDIFG 92 >5WRO-A nrPDB Length = 439 Score = 31.0 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 19/78 (24%), Positives = 28/78 (35%), Gaps = 13/78 (16%) Query: 197 SEAGVPPGLFNVVQGGAATGQFLCQHP----DVAKVSFTGSVPTGMKIMEMSAKGIKPVT 252 E +P FNV+ GG+ G L SFT ++ G ++ K + Sbjct: 147 KEIILPVPAFNVINGGSHAGNKLAMQEFMILPTGATSFTEAMKMGSEVYHHL-KNVIKAK 205 Query: 253 LEL--------GGKSPLI 262 L GG +P I Sbjct: 206 FGLDATAVGDEGGFAPNI 223 >6AHD-9 nrPDB Length = 800 Score = 31.0 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 15/79 (18%), Positives = 23/79 (29%), Gaps = 17/79 (21%) Query: 33 EPATGRVIATFTCSGEKEVNLAVQNAKAAF---------------KIWSQKSGM--ERCR 75 EP T VI +E+ + AK W + ER R Sbjct: 149 EPVTADVINPMALRQREELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSR 208 Query: 76 ILLEAARIIREREDEIATM 94 L + + +R + M Sbjct: 209 QLQKEKDLAEKRAKLLEEM 227 >3DOD-A nrPDB Length = 448 Score = 31.0 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 8/22 (36%), Positives = 14/22 (63%) Query: 73 RCRILLEAARIIREREDEIATM 94 R + L E A+++ E +EIA + Sbjct: 193 RDQCLRELAQLLEEHHEEIAAL 214 >1SU3-A nrPDB Length = 450 Score = 30.6 bits (68), Expect = 1.7, Method: Composition-based stats. Identities = 13/67 (19%), Positives = 25/67 (37%), Gaps = 13/67 (19%) Query: 4 GTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFK 63 G V+Q + G R E + + + P +V+ A++ AF+ Sbjct: 74 GVPDVAQFVLTEGNPRWEQTHLTYRIENYTP----------DLPRADVDHAIE---KAFQ 120 Query: 64 IWSQKSG 70 +WS + Sbjct: 121 LWSNVTP 127 >1FBL-A nrPDB Length = 370 Score = 30.6 bits (68), Expect = 1.7, Method: Composition-based stats. Identities = 7/27 (25%), Positives = 14/27 (51%), Gaps = 3/27 (11%) Query: 44 TCSGEKEVNLAVQNAKAAFKIWSQKSG 70 ++V+ A++ AF++WS S Sbjct: 24 PDLSREDVDRAIE---KAFQLWSNVSP 47 >5MMM-i nrPDB Length = 208 Score = 30.6 bits (68), Expect = 1.8, Method: Composition-based stats. Identities = 12/55 (21%), Positives = 20/55 (36%) Query: 175 NAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVS 229 N V KP T SA E+ A + + + + GG A + ++ Sbjct: 40 NPAVVKPLVITATSATAPVEVAETADLEKFVKSRLPGGFAAQTVIGTGRRKCAIA 94 >5J6F-A nrPDB Length = 368 Score = 30.2 bits (67), Expect = 2.2, Method: Composition-based stats. Identities = 21/98 (21%), Positives = 35/98 (35%), Gaps = 6/98 (6%) Query: 292 TRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGA 351 + V ++ E + + + +IGD MGP E+V + K+QG Sbjct: 92 KALLVSRKKHP---ENTIVEVKGERIGDGNQYFV-MGP-CAVESYEQVAAVAEAVKKQGI 146 Query: 352 KVLCGGDIYVPEDPKLKDGYYMRPC-VLTNCRDDMTCV 388 K+L GG P G + +L D+ Sbjct: 147 KLLRGGAYKPRTSPYDFQGLGVEGLKILKRIADEFDLA 184 >3TSB-A nrPDB Length = 511 Score = 30.2 bits (67), Expect = 2.4, Method: Composition-based stats. Identities = 15/72 (20%), Positives = 33/72 (45%), Gaps = 1/72 (1%) Query: 306 EEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDP 365 E+++++ + K+ G LI +E+V+ F AK++ ++L G + V D Sbjct: 199 EKILQKYKIEKLPLVDNNGVLQG-LITIKDIEKVIEFPNSAKDKQGRLLVGAAVGVTADA 257 Query: 366 KLKDGYYMRPCV 377 + ++ V Sbjct: 258 MTRIDALVKASV 269 >2R6F-A nrPDB Length = 972 Score = 29.8 bits (66), Expect = 2.8, Method: Composition-based stats. Identities = 21/78 (26%), Positives = 35/78 (44%), Gaps = 9/78 (11%) Query: 174 GNA-MVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTG 232 GN +V + T ++A L +I AG+ G VV G + + P+ S TG Sbjct: 556 GNTLIVVEHDEDTMLAADYLIDIGPGAGIHGG--EVVAAGTP--EEVMNDPN----SLTG 607 Query: 233 SVPTGMKIMEMSAKGIKP 250 +G K + + A+ +P Sbjct: 608 QYLSGKKFIPIPAERRRP 625 >3WUY-A nrPDB Length = 349 Score = 29.4 bits (65), Expect = 3.8, Method: Composition-based stats. Identities = 15/99 (15%), Positives = 39/99 (39%), Gaps = 13/99 (13%) Query: 319 DPLLEDTRMGPLINRPH--LERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPC 376 + ++ P++ +E+VL + A ++G +++ + +VP P ++ P Sbjct: 15 NIRAAAAQISPVLFSQQGTMEKVLDAIANAAKKGVELIVFPETFVPYYPYFS---FVEPP 71 Query: 377 VLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDT 415 VL + +E ++ + + +A T Sbjct: 72 VLMGKSH-LKLYQE-------AVTVPGKVTQAIAQAAKT 102 >4G5X-A nrPDB Length = 279 Score = 29.4 bits (65), Expect = 3.9, Method: Composition-based stats. Identities = 20/98 (20%), Positives = 40/98 (40%), Gaps = 8/98 (8%) Query: 189 ALLLAEIYSEAGVPPGL-FNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKG 247 A + E+ + G+ + F GG + + ++P++ + TG+ P E +G Sbjct: 81 ADAMTEVMQQLGIADAVVFGWSLGGHIGIEMIARYPEMRGLMITGTPPVAR---EEVGQG 137 Query: 248 IKPVT-LELGGKSPLIIFSDCDMNNAVKGALMANFLTQ 284 K + L G+ IFS+ D+ + + F Sbjct: 138 FKSGPDMALAGQE---IFSERDVESYARSTCGEPFEAS 172 >3UX8-A nrPDB Length = 670 Score = 29.4 bits (65), Expect = 3.9, Method: Composition-based stats. Identities = 21/78 (26%), Positives = 35/78 (44%), Gaps = 9/78 (11%) Query: 174 GNA-MVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTG 232 GN +V + T ++A L +I AG+ G VV G + + P+ S TG Sbjct: 254 GNTLIVVEHDEDTMLAADYLIDIGPGAGIHGG--EVVAAGTP--EEVMNDPN----SLTG 305 Query: 233 SVPTGMKIMEMSAKGIKP 250 +G K + + A+ +P Sbjct: 306 QYLSGKKFIPIPAERRRP 323 >3R11-A nrPDB Length = 379 Score = 29.4 bits (65), Expect = 4.0, Method: Composition-based stats. Identities = 13/47 (27%), Positives = 18/47 (38%), Gaps = 3/47 (6%) Query: 369 DGYYMRP--CVLTNCR-DDMTCVKEEIFGPVMSILSFDTEAEVLERA 412 GY + P +T M + EIF PV+ + LE A Sbjct: 45 KGYGVAPATTAITGDTLQGMQYIIREIFAPVILGSDLSDYKQTLELA 91 >1EAK-A nrPDB Length = 421 Score = 29.4 bits (65), Expect = 4.1, Method: Composition-based stats. Identities = 13/52 (25%), Positives = 21/52 (40%), Gaps = 3/52 (5%) Query: 33 EPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARII 84 T R+I + V+ A AF++WS + + RI A I+ Sbjct: 91 NQITYRIIGYTPDLDPETVDDAFA---RAFQVWSDVTPLRFSRIHDGEADIM 139 >1CK7-A nrPDB Length = 631 Score = 29.4 bits (65), Expect = 4.1, Method: Composition-based stats. Identities = 13/52 (25%), Positives = 21/52 (40%), Gaps = 3/52 (5%) Query: 33 EPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARII 84 T R+I + V+ A AF++WS + + RI A I+ Sbjct: 93 NQITYRIIGYTPDLDPETVDDAFA---RAFQVWSDVTPLRFSRIHDGEADIM 141 >2Q9B-A nrPDB Length = 304 Score = 29.0 bits (64), Expect = 4.7, Method: Composition-based stats. Identities = 11/47 (23%), Positives = 18/47 (38%), Gaps = 5/47 (10%) Query: 35 ATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAA 81 AT ++ SG K++ AV+ K+ ER L + Sbjct: 48 ATEEILQEVRASGRKDLKEAVKE-----KLVGMLEPDERRATLRKLG 89 >3IWA-A nrPDB Length = 472 Score = 29.0 bits (64), Expect = 4.9, Method: Composition-based stats. Identities = 16/89 (17%), Positives = 28/89 (31%), Gaps = 2/89 (2%) Query: 301 LDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY 360 DK + + R + L P+ N E V + + A ++ GG I Sbjct: 114 YDKLVLALGSKANRPPVEGMDLAGVT--PVTNLDEAEFVQHAISAGEVSKAVIVGGGFIG 171 Query: 361 VPEDPKLKDGYYMRPCVLTNCRDDMTCVK 389 + L D + + V+ M Sbjct: 172 LEMAVSLADMWGIDTTVVELADQIMPGFT 200 >4XFE-A nrPDB Length = 341 Score = 29.0 bits (64), Expect = 5.2, Method: Composition-based stats. Identities = 16/68 (23%), Positives = 24/68 (35%), Gaps = 10/68 (14%) Query: 98 NNGKSIFEAR-LDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGA- 155 N GK + +A DI + +AG E I+ R LG+ + Sbjct: 45 NMGKKLEQASNGDI-----TFKMFAGGVLGSEKEVIEQAQIGAVQMTRVSLGIVGPVVPD 99 Query: 156 ---WNYPF 160 +N PF Sbjct: 100 VNVFNMPF 107 >1QIB-A nrPDB Length = 161 Score = 29.0 bits (64), Expect = 5.4, Method: Composition-based stats. Identities = 13/52 (25%), Positives = 21/52 (40%), Gaps = 3/52 (5%) Query: 33 EPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARII 84 T R+I + V+ A AF++WS + + RI A I+ Sbjct: 8 NQITYRIIGYTPDLDPETVDDAFA---RAFQVWSDVTPLRFSRIHDGEADIM 56 >3TFC-A nrPDB Length = 385 Score = 28.7 bits (63), Expect = 5.6, Method: Composition-based stats. Identities = 15/80 (18%), Positives = 29/80 (36%), Gaps = 5/80 (6%) Query: 291 GTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQG 350 + V ++ E+ + + + IG+ GP + E+V + K +G Sbjct: 115 SKALLVSRKNK---KEDTIVTVKGLPIGNG-EPVFVFGP-CSVESYEQVAAVAESIKAKG 169 Query: 351 AKVLCGGDIYVPEDPKLKDG 370 K++ GG P G Sbjct: 170 LKLIRGGAFKPRTSPYDFQG 189 >2IPH-A nrPDB Length = 181 Score = 28.7 bits (63), Expect = 6.8, Method: Composition-based stats. Identities = 9/31 (29%), Positives = 15/31 (48%), Gaps = 1/31 (3%) Query: 370 GYYMRPCVLTNCRDDMTCVKEEIFG-PVMSI 399 G+++ P V + +E FG P+ SI Sbjct: 17 GFWVSPTVFITTTHVIPTSAKEFFGEPLTSI 47 >6C0F-8 nrPDB Length = 434 Score = 28.3 bits (62), Expect = 7.3, Method: Composition-based stats. Identities = 15/55 (27%), Positives = 25/55 (45%), Gaps = 1/55 (1%) Query: 47 GEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGK 101 EK + A++ K A K S ER R++ + ++R +E + N GK Sbjct: 343 DEKLLRKAIKR-KEAQKRKSAIEWSERKRVVEDTISERQKRREENLRIRKDNKGK 396 >4ILK-A nrPDB Length = 359 Score = 28.3 bits (62), Expect = 7.9, Method: Composition-based stats. Identities = 19/116 (16%), Positives = 38/116 (32%), Gaps = 23/116 (19%) Query: 296 VQKEILDK---FTEEVVKQTQRIKIGDPLLEDTRM----GP--------------LINRP 334 + + + D+ E G P DT + GP + N Sbjct: 151 IPEAVADQYAVMIEPFTIAANVTGHGQPTENDTVLVYGAGPIGLTIVQVLKGVYNVKNVI 210 Query: 335 HLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKE 390 +R+ ++ AKE GA + + G ++P ++ + + +KE Sbjct: 211 VADRIDERLEKAKESGADWAINNSQTPLGESFAEKG--IKPTLIIDAACHPSILKE 264 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.312 0.156 0.455 Lambda K H 0.267 0.0481 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 21,838,128 Number of Sequences: 36641 Number of extensions: 1018803 Number of successful extensions: 4375 Number of sequences better than 10.0: 157 Number of HSP's better than 10.0 without gapping: 218 Number of HSP's successfully gapped in prelim test: 50 Number of HSP's that attempted gapping in prelim test: 3225 Number of HSP's gapped (non-prelim): 303 length of query: 494 length of database: 10,336,785 effective HSP length: 101 effective length of query: 393 effective length of database: 6,636,044 effective search space: 2607965292 effective search space used: 2607965292 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 62 (28.3 bits)