BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P49137 (400 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1NY3-A nrPDB 833 0.0 2OZA-A nrPDB 742 0.0 3KA0-A nrPDB 673 0.0 3M42-A nrPDB 612 e-175 3FXW-A nrPDB 525 e-149 4MVF-A nrPDB 211 4e-55 4NIF-A nrPDB 206 2e-53 4FG9-A nrPDB 198 4e-51 2JAM-A nrPDB 191 3e-49 2JC6-A nrPDB 191 5e-49 2W4O-A nrPDB 191 5e-49 4JG6-A nrPDB 191 7e-49 3KN6-A nrPDB 183 1e-46 3NCG-A nrPDB 183 1e-46 3HZT-A nrPDB 183 1e-46 3DXN-A nrPDB 182 2e-46 3LIJ-A nrPDB 180 1e-45 3DFA-A nrPDB 178 3e-45 3F3Z-A nrPDB 176 1e-44 5IG1-A nrPDB 174 6e-44 5FG8-A nrPDB 173 1e-43 2HW6-A nrPDB 172 2e-43 5JN2-A nrPDB 169 2e-42 5JZN-A nrPDB 167 7e-42 3KK8-A nrPDB 167 9e-42 2BDW-A nrPDB 167 1e-41 2YCR-A nrPDB 166 2e-41 3Q5I-A nrPDB 166 2e-41 3MA6-A nrPDB 165 4e-41 3I6U-A nrPDB 162 2e-40 2VN9-A nrPDB 162 2e-40 2V7O-A nrPDB 161 5e-40 4YZB-A nrPDB 160 6e-40 2Y7J-A nrPDB 159 1e-39 3BHH-A nrPDB 159 3e-39 6CKI-A nrPDB 157 6e-39 2VZ6-A nrPDB 157 1e-38 5U6Y-A nrPDB 156 2e-38 3SOA-A nrPDB 154 6e-38 3TAC-A nrPDB 154 7e-38 1PHK-A nrPDB 150 9e-37 3GUB-A nrPDB 150 1e-36 2J90-A nrPDB 149 1e-36 4RGJ-A nrPDB 148 4e-36 5XZW-A nrPDB 147 9e-36 2YAB-A nrPDB 143 1e-34 4PDS-A nrPDB 142 3e-34 1KOA-A nrPDB 141 5e-34 3UTO-A nrPDB 141 5e-34 2X4F-A nrPDB 139 2e-33 5YKS-A nrPDB 139 2e-33 2A27-A nrPDB 139 3e-33 1ZWS-A nrPDB 139 3e-33 1KOB-A nrPDB 137 9e-33 4WB7-A nrPDB 135 4e-32 5X3F-B nrPDB 135 4e-32 3UDB-A nrPDB 133 1e-31 4CFF-A nrPDB 133 2e-31 4CQG-A nrPDB 132 2e-31 5EZV-A nrPDB 132 2e-31 5N23-A nrPDB 132 3e-31 4D28-A nrPDB 131 4e-31 4CZT-A nrPDB 130 9e-31 4CFH-A nrPDB 130 1e-30 4YNZ-A nrPDB 129 2e-30 3LM0-A nrPDB 129 2e-30 4REW-A nrPDB 129 2e-30 5WAX-A nrPDB 129 3e-30 4D2V-A nrPDB 129 3e-30 3HDN-A nrPDB 128 4e-30 3ZUT-A nrPDB 127 9e-30 3IS5-A nrPDB 126 1e-29 4RED-A nrPDB 125 2e-29 1FOT-A nrPDB 125 2e-29 2JDO-A nrPDB 125 3e-29 1TKI-A nrPDB 124 6e-29 5ES1-A nrPDB 124 7e-29 2YZA-A nrPDB 124 9e-29 6BDL-A nrPDB 122 3e-28 5KZ7-A nrPDB 122 4e-28 3D2K-A nrPDB 121 5e-28 3H4J-B nrPDB 121 7e-28 6FDY-U nrPDB 120 9e-28 4UZD-A nrPDB 120 9e-28 2QNJ-A nrPDB 120 1e-27 3HKO-A nrPDB 120 1e-27 3MN3-A nrPDB 120 1e-27 3UC3-A nrPDB 120 1e-27 4B8L-A nrPDB 117 6e-27 5KCV-A nrPDB 115 3e-26 3MV5-A nrPDB 115 4e-26 4JXF-A nrPDB 115 5e-26 2HAK-A nrPDB 112 2e-25 4L42-A nrPDB 112 2e-25 4RLP-A nrPDB 111 5e-25 5F9E-A nrPDB 110 7e-25 6C9D-A nrPDB 110 7e-25 6ED6-A nrPDB 109 2e-24 1VZO-A nrPDB 108 4e-24 5D9K-A nrPDB 107 8e-24 4AF3-A nrPDB 105 5e-23 2F57-A nrPDB 103 1e-22 6QAU-A nrPDB 103 1e-22 5FET-A nrPDB 103 2e-22 2Z7Q-A nrPDB 103 2e-22 4KS7-A nrPDB 102 4e-22 6E9W-A nrPDB 101 5e-22 2OU7-A nrPDB 100 8e-22 6FD3-A nrPDB 100 9e-22 3DB8-A nrPDB 100 1e-21 4J52-A nrPDB 100 1e-21 5DYK-A nrPDB 100 2e-21 3TXO-A nrPDB 100 2e-21 5LOH-A nrPDB 97 9e-21 3A8W-A nrPDB 97 1e-20 3Q53-A nrPDB 97 1e-20 4FIE-A nrPDB 96 2e-20 4RA4-A nrPDB 96 2e-20 4QMW-A nrPDB 96 3e-20 2BRG-A nrPDB 96 3e-20 6BXI-A nrPDB 96 4e-20 4JDH-A nrPDB 96 4e-20 3COM-A nrPDB 95 4e-20 4KIK-B nrPDB 95 5e-20 6CCF-A nrPDB 94 7e-20 4WNO-A nrPDB 94 8e-20 2Q0N-A nrPDB 94 1e-19 6CMJ-A nrPDB 93 2e-19 4B6L-A nrPDB 93 2e-19 4XBR-A nrPDB 93 2e-19 4APC-A nrPDB 92 3e-19 4AW2-A nrPDB 92 3e-19 3BGP-A nrPDB 91 9e-19 3PFQ-A nrPDB 91 9e-19 2I0E-A nrPDB 91 1e-18 5TUR-A nrPDB 91 1e-18 4RC3-A nrPDB 91 1e-18 3TKU-A nrPDB 91 1e-18 6AO5-A nrPDB 91 1e-18 4LG4-A nrPDB 90 1e-18 5YV8-A nrPDB 89 3e-18 4EQM-A nrPDB 89 5e-18 4FZF-B nrPDB 88 6e-18 4I6B-A nrPDB 88 6e-18 6E2O-A nrPDB 88 7e-18 2UV2-A nrPDB 87 1e-17 2WQN-A nrPDB 87 1e-17 3ORZ-A nrPDB 87 1e-17 5CEK-A nrPDB 86 2e-17 6DTL-A nrPDB 86 2e-17 6DC0-A nrPDB 86 2e-17 5L2Q-C nrPDB 86 3e-17 5J5T-A nrPDB 86 3e-17 3QA8-A nrPDB 86 3e-17 5AIR-A nrPDB 86 3e-17 2XIK-A nrPDB 86 4e-17 5Z33-A nrPDB 84 8e-17 4BGQ-A nrPDB 84 9e-17 5ZTN-A nrPDB 84 1e-16 5VO2-A nrPDB 84 1e-16 3EB0-A nrPDB 83 2e-16 4YHJ-A nrPDB 83 2e-16 5O0Y-A nrPDB 83 2e-16 3ORP-A nrPDB 83 2e-16 3DLS-A nrPDB 83 3e-16 4OW8-A nrPDB 82 3e-16 3NIZ-A nrPDB 82 3e-16 4X3F-A nrPDB 82 4e-16 4CRS-A nrPDB 82 4e-16 4TNB-A nrPDB 82 5e-16 4C0T-A nrPDB 82 6e-16 4AGU-A nrPDB 81 7e-16 6B2Q-A nrPDB 81 8e-16 6HXF-B nrPDB 81 1e-15 4X7Q-B nrPDB 80 1e-15 4UY9-A nrPDB 80 2e-15 5TQX-A nrPDB 79 2e-15 5O2C-A nrPDB 79 3e-15 2XNP-A nrPDB 79 3e-15 4AU8-A nrPDB 79 3e-15 3DAK-A nrPDB 79 3e-15 5X8I-B nrPDB 79 4e-15 4OTD-A nrPDB 79 4e-15 4E7W-A nrPDB 79 4e-15 4QTB-A nrPDB 79 4e-15 6FYV-A nrPDB 78 6e-15 2W96-B nrPDB 78 7e-15 5O2B-A nrPDB 78 7e-15 5D7A-A nrPDB 77 1e-14 3NYO-A nrPDB 77 2e-14 3DTC-A nrPDB 77 2e-14 5UNP-A nrPDB 76 2e-14 4FR4-A nrPDB 76 2e-14 3C51-A nrPDB 76 3e-14 6CQF-A nrPDB 76 3e-14 4MYG-A nrPDB 75 4e-14 3ZDU-A nrPDB 75 4e-14 5EFQ-A nrPDB 75 5e-14 3E7O-A nrPDB 75 5e-14 4PWN-A nrPDB 75 6e-14 2WTK-C nrPDB 75 6e-14 4NST-A nrPDB 75 6e-14 1ZXE-A nrPDB 75 6e-14 1G3N-A nrPDB 74 8e-14 2I6L-A nrPDB 74 9e-14 4LQP-A nrPDB 74 1e-13 5DBX-A nrPDB 74 1e-13 5Y86-A nrPDB 74 1e-13 1U5R-A nrPDB 74 2e-13 5AWM-A nrPDB 73 2e-13 2GCD-A nrPDB 73 2e-13 3UIU-A nrPDB 73 2e-13 4LFI-A nrPDB 73 2e-13 3ALO-A nrPDB 73 2e-13 6O6Q-A nrPDB 72 4e-13 3E3P-A nrPDB 72 4e-13 4EWQ-A nrPDB 72 4e-13 6GVJ-A nrPDB 72 5e-13 2XS0-A nrPDB 71 7e-13 4IAN-A nrPDB 71 7e-13 4EUT-A nrPDB 71 8e-13 4QNY-A nrPDB 71 9e-13 4PDO-A nrPDB 71 9e-13 5NGU-A nrPDB 71 1e-12 2A1A-B nrPDB 71 1e-12 4BBM-A nrPDB 71 1e-12 3OZ6-A nrPDB 71 1e-12 4EUU-A nrPDB 71 1e-12 3GC9-A nrPDB 70 1e-12 6NT9-A nrPDB 70 1e-12 4UYA-A nrPDB 70 1e-12 1JNK-A nrPDB 70 1e-12 3RAW-A nrPDB 70 1e-12 3HMP-A nrPDB 70 1e-12 4TPT-A nrPDB 70 1e-12 3N9X-A nrPDB 70 2e-12 3FI2-A nrPDB 70 2e-12 2ZMD-A nrPDB 70 2e-12 4JLC-A nrPDB 70 2e-12 5HVK-A nrPDB 70 2e-12 1UA2-A nrPDB 70 2e-12 1CM8-A nrPDB 69 2e-12 5AP3-A nrPDB 69 3e-12 6O8B-A nrPDB 69 3e-12 4U41-A nrPDB 69 3e-12 3OHT-A nrPDB 69 3e-12 2BPM-A nrPDB 69 3e-12 3VN9-A nrPDB 69 4e-12 2F9G-A nrPDB 69 4e-12 4O2Z-A nrPDB 68 9e-12 1V0B-A nrPDB 68 9e-12 4IDT-A nrPDB 67 9e-12 5TE0-A nrPDB 67 1e-11 2VD5-A nrPDB 67 1e-11 4KRC-A nrPDB 67 1e-11 4MD7-E nrPDB 66 2e-11 3KUL-B nrPDB 66 2e-11 4GS6-A nrPDB 66 2e-11 2VWV-A nrPDB 66 3e-11 6EII-A nrPDB 66 3e-11 6HMD-A nrPDB 66 3e-11 2H34-A nrPDB 66 3e-11 4PL5-B nrPDB 65 3e-11 4XLV-A nrPDB 65 4e-11 4E93-A nrPDB 65 4e-11 3FME-A nrPDB 65 4e-11 1JPA-A nrPDB 65 4e-11 4IC8-A nrPDB 65 5e-11 2BUJ-A nrPDB 65 6e-11 4Y83-A nrPDB 65 6e-11 3MIA-A nrPDB 65 7e-11 3RP9-A nrPDB 65 7e-11 2RIO-A nrPDB 64 8e-11 3NIE-A nrPDB 64 8e-11 3PPZ-A nrPDB 64 1e-10 4OLI-A nrPDB 64 1e-10 2PVN-A nrPDB 64 1e-10 5UUU-A nrPDB 64 1e-10 3PVW-A nrPDB 64 1e-10 2OZO-A nrPDB 64 1e-10 5MJB-A nrPDB 64 1e-10 5H2U-A nrPDB 64 2e-10 5M07-A nrPDB 63 2e-10 1U59-A nrPDB 63 2e-10 5B2L-A nrPDB 63 2e-10 5KKR-C nrPDB 63 2e-10 4G3E-A nrPDB 63 3e-10 6DBM-A nrPDB 63 3e-10 2Y6O-A nrPDB 63 3e-10 4ZSG-A nrPDB 62 3e-10 4EBW-A nrPDB 62 3e-10 5IKW-A nrPDB 62 3e-10 4FL3-A nrPDB 62 4e-10 4Y93-A nrPDB 62 4e-10 5L6P-A nrPDB 62 4e-10 1K9A-A nrPDB 62 4e-10 5OAT-A nrPDB 62 4e-10 2WO6-A nrPDB 62 4e-10 3EQC-A nrPDB 62 5e-10 4P5Q-A nrPDB 62 5e-10 4C59-A nrPDB 62 6e-10 1BYG-A nrPDB 62 6e-10 5G6V-A nrPDB 62 6e-10 1S9I-A nrPDB 62 6e-10 5VD3-A nrPDB 62 6e-10 6GU6-A nrPDB 61 7e-10 4AN9-A nrPDB 61 7e-10 5XVU-A nrPDB 61 7e-10 2R2P-A nrPDB 61 9e-10 4CRL-A nrPDB 61 1e-09 5C26-A nrPDB 61 1e-09 4M7I-A nrPDB 61 1e-09 2J0K-A nrPDB 60 1e-09 2PMN-X nrPDB 60 1e-09 3DKO-A nrPDB 60 1e-09 6HV0-A nrPDB 60 2e-09 3QD2-B nrPDB 60 2e-09 2W1I-A nrPDB 59 3e-09 3IO7-A nrPDB 59 3e-09 4HVI-A nrPDB 59 3e-09 5EG3-A nrPDB 59 5e-09 3BEA-A nrPDB 58 6e-09 4XI2-A nrPDB 58 6e-09 4F0G-A nrPDB 58 7e-09 4F9B-A nrPDB 58 8e-09 3OMV-A nrPDB 57 1e-08 6CTH-A nrPDB 57 1e-08 2PSQ-A nrPDB 57 2e-08 4CSV-A nrPDB 57 2e-08 2PZI-A nrPDB 57 2e-08 2OGV-A nrPDB 56 2e-08 6E4F-A nrPDB 56 2e-08 3PG1-A nrPDB 56 3e-08 4H1J-A nrPDB 56 3e-08 5X5O-A nrPDB 56 3e-08 3GC0-A nrPDB 56 3e-08 2QKW-B nrPDB 56 3e-08 4AT3-A nrPDB 55 4e-08 4E20-A nrPDB 55 4e-08 5HI2-A nrPDB 55 5e-08 5A46-A nrPDB 55 6e-08 5GRN-A nrPDB 55 7e-08 3GQL-A nrPDB 55 8e-08 4Y12-A nrPDB 54 9e-08 3KRL-A nrPDB 54 1e-07 2DQ7-X nrPDB 54 1e-07 5VC6-A nrPDB 54 1e-07 2Y4I-B nrPDB 54 1e-07 3TT0-A nrPDB 54 1e-07 4R7H-A nrPDB 53 2e-07 3AOX-A nrPDB 53 3e-07 4K33-A nrPDB 53 3e-07 5AMN-A nrPDB 52 3e-07 2H8H-A nrPDB 52 3e-07 3QUP-A nrPDB 52 4e-07 5KMM-A nrPDB 52 4e-07 6F3F-A nrPDB 52 5e-07 5HIE-A nrPDB 52 5e-07 4XCU-A nrPDB 52 5e-07 2JD5-A nrPDB 52 5e-07 3LLT-A nrPDB 52 6e-07 5SYS-A nrPDB 52 7e-07 6NPU-A nrPDB 51 7e-07 4XEY-B nrPDB 51 7e-07 4NFN-A nrPDB 51 7e-07 4BTK-A nrPDB 51 8e-07 5FM2-A nrPDB 51 9e-07 3V5Q-A nrPDB 51 9e-07 5VDK-A nrPDB 51 9e-07 3VHK-A nrPDB 51 1e-06 3ZBF-A nrPDB 50 1e-06 3QGY-A nrPDB 50 1e-06 2HK5-A nrPDB 50 2e-06 3CJF-A nrPDB 50 2e-06 3I81-A nrPDB 50 2e-06 3HNG-A nrPDB 50 2e-06 4NT4-A nrPDB 50 2e-06 2FO0-A nrPDB 50 2e-06 6J5U-C nrPDB 49 3e-06 2XYN-A nrPDB 49 4e-06 4TN6-A nrPDB 49 4e-06 5LPZ-A nrPDB 49 5e-06 5LPV-A nrPDB 49 5e-06 2PL0-A nrPDB 49 6e-06 3SXS-A nrPDB 48 6e-06 5U6C-A nrPDB 48 9e-06 5UIU-A nrPDB 47 1e-05 5FQD-C nrPDB 47 1e-05 3A4O-X nrPDB 47 1e-05 2CMW-A nrPDB 47 1e-05 4XHL-A nrPDB 47 1e-05 3G0E-A nrPDB 47 2e-05 4HZS-A nrPDB 47 2e-05 3SV0-A nrPDB 47 2e-05 1U54-B nrPDB 46 2e-05 2C47-A nrPDB 46 2e-05 5U6B-A nrPDB 46 2e-05 1AD5-A nrPDB 46 2e-05 6FEX-A nrPDB 46 3e-05 5HLW-A nrPDB 46 3e-05 4NEU-A nrPDB 46 3e-05 6BSD-A nrPDB 46 3e-05 4XHH-A nrPDB 45 4e-05 3PP0-A nrPDB 45 5e-05 3ZZW-A nrPDB 45 7e-05 6GQK-A nrPDB 45 7e-05 3C1X-A nrPDB 45 8e-05 5TOS-A nrPDB 44 1e-04 2CHL-A nrPDB 44 1e-04 3BBT-B nrPDB 44 1e-04 1CSN-A nrPDB 44 1e-04 6DBN-A nrPDB 44 1e-04 4XUF-A nrPDB 44 1e-04 5GNK-A nrPDB 44 1e-04 5WNO-A nrPDB 44 1e-04 5X02-A nrPDB 44 1e-04 4RT7-A nrPDB 44 2e-04 3UIM-A nrPDB 44 2e-04 1LUF-A nrPDB 43 2e-04 6EQI-C nrPDB 42 5e-04 4M66-A nrPDB 42 5e-04 3REP-A nrPDB 42 6e-04 1FVR-A nrPDB 42 7e-04 3LZB-A nrPDB 41 7e-04 6FER-A nrPDB 41 8e-04 4IX6-A nrPDB 41 8e-04 4LRM-A nrPDB 41 0.001 3PLS-A nrPDB 41 0.001 5X18-A nrPDB 40 0.002 4JRN-A nrPDB 40 0.002 5CLR-A nrPDB 40 0.002 5C01-A nrPDB 39 0.005 4WOV-A nrPDB 39 0.005 3G2F-A nrPDB 39 0.005 3SOC-A nrPDB 38 0.007 3Q4U-A nrPDB 37 0.010 2QLU-A nrPDB 37 0.011 2LAV-A nrPDB 37 0.014 2RSV-A nrPDB 37 0.016 5XD6-A nrPDB 37 0.019 6BHC-A nrPDB 37 0.019 3LMG-A nrPDB 37 0.022 2WTK-B nrPDB 36 0.038 5X1R-A nrPDB 35 0.049 4OAU-C nrPDB 35 0.055 2X7G-A nrPDB 35 0.055 6G4J-A nrPDB 35 0.056 4BTF-A nrPDB 34 0.11 5UU1-A nrPDB 34 0.11 3MDY-A nrPDB 34 0.11 1PY5-A nrPDB 34 0.12 4M69-B nrPDB 34 0.13 5AC0-A nrPDB 33 0.20 4O1O-A nrPDB 33 0.20 3MY0-A nrPDB 33 0.31 3Q60-A nrPDB 32 0.34 5DMZ-A nrPDB 32 0.38 2JII-A nrPDB 32 0.39 4L00-A nrPDB 32 0.68 4WUA-A nrPDB 31 0.95 4MWI-A nrPDB 31 1.1 6DCE-A nrPDB 31 1.2 6GMA-A nrPDB 30 1.4 4UUD-B nrPDB 30 1.5 3ENH-A nrPDB 30 1.9 5UV4-A nrPDB 30 2.7 5AC2-A nrPDB 28 7.0 >1NY3-A nrPDB Length = 400 Score = 833 bits (2151), Expect = 0.0, Method: Compositional matrix adjust. Identities = 400/400 (100%), Positives = 400/400 (100%) Query: 1 MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII 60 MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII Sbjct: 1 MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII 60 Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI 120 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI Sbjct: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI 120 Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI Sbjct: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY 240 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY Sbjct: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY 240 Query: 241 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 300 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM Sbjct: 241 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 300 Query: 301 LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL 360 LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL Sbjct: 301 LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL 360 Query: 361 ATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH 400 ATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH Sbjct: 361 ATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH 400 >2OZA-A nrPDB Length = 356 Score = 742 bits (1916), Expect = 0.0, Method: Compositional matrix adjust. Identities = 354/354 (100%), Positives = 354/354 (100%) Query: 47 HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE 106 HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE Sbjct: 3 HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE 62 Query: 107 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI Sbjct: 63 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 122 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 226 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT Sbjct: 123 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 182 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF Sbjct: 183 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 242 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDK 346 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDK Sbjct: 243 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDK 302 Query: 347 ERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH 400 ERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH Sbjct: 303 ERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH 356 >3KA0-A nrPDB Length = 320 Score = 673 bits (1737), Expect = 0.0, Method: Compositional matrix adjust. Identities = 319/320 (99%), Positives = 319/320 (99%) Query: 47 HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE 106 HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE Sbjct: 1 HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE 60 Query: 107 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI Sbjct: 61 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 120 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 226 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT PCYT Sbjct: 121 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYT 180 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF Sbjct: 181 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 240 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDK 346 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDK Sbjct: 241 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDK 300 Query: 347 ERWEDVKEEMTSALATMRVD 366 ERWEDVKEEMTSALATMRVD Sbjct: 301 ERWEDVKEEMTSALATMRVD 320 >3M42-A nrPDB Length = 299 Score = 612 bits (1577), Expect = e-175, Method: Compositional matrix adjust. Identities = 296/318 (93%), Positives = 296/318 (93%), Gaps = 21/318 (6%) Query: 47 HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE 106 HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE Sbjct: 3 HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE 62 Query: 107 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI Sbjct: 63 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 122 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 226 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT Sbjct: 123 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTG---------- 172 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286 EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF Sbjct: 173 -----------EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 221 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDK 346 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDK Sbjct: 222 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDK 281 Query: 347 ERWEDVKEEMTSALATMR 364 ERWEDVKEEMTSALATMR Sbjct: 282 ERWEDVKEEMTSALATMR 299 >3FXW-A nrPDB Length = 336 Score = 525 bits (1351), Expect = e-149, Method: Compositional matrix adjust. Identities = 245/328 (74%), Positives = 289/328 (88%), Gaps = 8/328 (2%) Query: 50 SGLQI-------KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR 102 SGL++ KK A+ DDY+++ QVLGLG+NGKVL+ F++RT +K ALK+L D PKAR Sbjct: 10 SGLEVLFQGPEPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKAR 69 Query: 103 REVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTERE 162 +EV+ HW+AS PHIV I+DVYEN++ G++CLLI+MEC++GGELFSRIQ+RGDQAFTERE Sbjct: 70 QEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTERE 129 Query: 163 ASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTT 222 A+EIM+ IG AIQ+LHS NIAHRDVKPENLLYTSK +A+LKLTDFGFAKETT N+L T Sbjct: 130 AAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETT-QNALQT 188 Query: 223 PCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMG 282 PCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCG+PPFYSN G AISPGMK RIR+G Sbjct: 189 PCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLG 248 Query: 283 QYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVL 342 QY FPNPEWSEVSE+ K LIR LLKT+PT+R+TIT+FMNHPWI QS VPQTPLHT+RVL Sbjct: 249 QYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVL 308 Query: 343 KEDKERWEDVKEEMTSALATMRVDYEQI 370 +EDK+ W++VKEEMTSALATMRVDY+Q+ Sbjct: 309 QEDKDHWDEVKEEMTSALATMRVDYDQV 336 >4MVF-A nrPDB Length = 506 Score = 211 bits (538), Expect = 4e-55, Method: Compositional matrix adjust. Identities = 116/289 (40%), Positives = 170/289 (58%), Gaps = 17/289 (5%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALK-----MLQDCPKARREVELHWRASQC 114 ++D + + LG G G V + +K T + +A+K L++ + +E+E+ + Sbjct: 55 LEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKLDH- 113 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 P+IV++ + YEN + ++ME G ELF I + G +FTE+ A+ IMK I AI Sbjct: 114 PNIVKLYETYEN----DNYIYLIMELCSGRELFDSIIENG--SFTEKNAATIMKQIFSAI 167 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV 234 YLHS+NI HRD+KPEN L+ S+ +++LK+ DFG +K + TT TPYYVAP+V Sbjct: 168 FYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQV 227 Query: 235 LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 294 L KYDK CD+WS GVIMY LLCGYPPFY + + +++ G++ F +W + Sbjct: 228 LDG-KYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLK----KVKKGEFCFYENDWGSI 282 Query: 295 SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLK 343 S + K LI LL P +R TI E +NHPWI Q TK + +S +LK Sbjct: 283 SSDAKNLITKLLTYNPNERCTIEEALNHPWITQMTKSHEHVELSSTLLK 331 >4NIF-A nrPDB Length = 333 Score = 206 bits (523), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 106/284 (37%), Positives = 171/284 (60%), Gaps = 12/284 (4%) Query: 57 NAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKA-RREVELHWRASQCP 115 N + D V + +G+G + + +K T ++A+K++ + E+E+ R Q P Sbjct: 3 NLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHP 62 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 +I+ + DVY++ K + +V E + GGEL +I + + F+EREAS ++ +IG+ ++ Sbjct: 63 NIITLKDVYDD----GKHVYLVTELMRGGELLDKILRQ--KFFSEREASFVLHTIGKTVE 116 Query: 176 YLHSINIAHRDVKPENLLYTSKRPN-AILKLTDFGFAKETTSHNSL-TTPCYTPYYVAPE 233 YLHS + HRD+KP N+LY + N L++ DFGFAK+ + N L TPCYT +VAPE Sbjct: 117 YLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPE 176 Query: 234 VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISP-GMKTRIRMGQYEFPNPEWS 292 VL + YD+ CD+WSLG+++Y +L GY PF +G + +P + TRI G++ W+ Sbjct: 177 VLKRQGYDEGCDIWSLGILLYTMLAGYTPF--ANGPSDTPEEILTRIGSGKFTLSGGNWN 234 Query: 293 EVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPL 336 VSE K L+ +L +P QR+T + + HPW+ Q K+PQ+ L Sbjct: 235 TVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQL 278 >4FG9-A nrPDB Length = 320 Score = 198 bits (503), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 106/276 (38%), Positives = 165/276 (59%), Gaps = 16/276 (5%) Query: 69 VLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRAS-----QCPHIVRIVDV 123 VLG G +V+ +KRTQ+ A+K + +E + + + P+IV + D+ Sbjct: 25 VLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIVALDDI 84 Query: 124 YENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIA 183 YE+ G L ++M+ + GGELF RI ++G +TER+AS ++ + +A++YLH + I Sbjct: 85 YES--GGH--LYLIMQLVSGGELFDRIVEKG--FYTERDASRLIFQVLDAVKYLHDLGIV 138 Query: 184 HRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKS 243 HRD+KPENLLY S ++ + ++DFG +K + L+T C TP YVAPEVL + Y K+ Sbjct: 139 HRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKA 198 Query: 244 CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIR 303 D WS+GVI YILLCGYPPFY + + +I +YEF +P W ++S+ K IR Sbjct: 199 VDCWSIGVIAYILLCGYPPFYDEN----DAKLFEQILKAEYEFDSPYWDDISDSAKDFIR 254 Query: 304 NLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTS 339 +L++ +P +R T + + HPWI T + + +H S Sbjct: 255 HLMEKDPEKRFTCEQALQHPWIAGDTALDKN-IHQS 289 >2JAM-A nrPDB Length = 304 Score = 191 bits (486), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 110/291 (37%), Positives = 166/291 (57%), Gaps = 22/291 (7%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELH-----WRASQCPHIVRIVD 122 +VLG G +V + + T + FALK ++ P A R+ L + + +IV + D Sbjct: 15 EVLGSGAFSEVFLVKQRLTGKLFALKCIKKSP-AFRDSSLENEIAVLKKIKHENIVTLED 73 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182 +YE+ +VM+ + GGELF RI +RG +TE++AS +++ + A++YLH I Sbjct: 74 IYES----TTHYYLVMQLVSGGELFDRILERG--VYTEKDASLVIQQVLSAVKYLHENGI 127 Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDK 242 HRD+KPENLLY + N+ + +TDFG +K + ++T C TP YVAPEVL + Y K Sbjct: 128 VHRDLKPENLLYLTPEENSKIMITDFGLSK-MEQNGIMSTACGTPGYVAPEVLAQKPYSK 186 Query: 243 SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI 302 + D WS+GVI YILLCGYPPFY + +I+ G YEF +P W ++SE K I Sbjct: 187 AVDCWSIGVITYILLCGYPPFYEE----TESKLFEKIKEGYYEFESPFWDDISESAKDFI 242 Query: 303 RNLLKTEPTQRMTITEFMNHPWIMQSTKV-----PQTPLHTSRVLKEDKER 348 +LL+ +P +R T + ++HPWI +T + P L + + K R Sbjct: 243 CHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNFAKSKWR 293 >2JC6-A nrPDB Length = 334 Score = 191 bits (485), Expect = 5e-49, Method: Compositional matrix adjust. Identities = 103/277 (37%), Positives = 160/277 (57%), Gaps = 16/277 (5%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELH-----WRASQCPHIVRIVD 122 + LG G +V+ K T + FA+K + +E + R + +IV + D Sbjct: 28 ETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALED 87 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182 +YE+ L +VM+ + GGELF RI ++G +TE++AS +++ + +A+ YLH + I Sbjct: 88 IYES----PNHLYLVMQLVSGGELFDRIVEKG--FYTEKDASTLIRQVLDAVYYLHRMGI 141 Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDK 242 HRD+KPENLLY S+ + + ++DFG +K + ++T C TP YVAPEVL + Y K Sbjct: 142 VHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSK 201 Query: 243 SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI 302 + D WS+GVI YILLCGYPPFY + + +I +YEF +P W ++S+ K I Sbjct: 202 AVDCWSIGVIAYILLCGYPPFYDEN----DSKLFEQILKAEYEFDSPYWDDISDSAKDFI 257 Query: 303 RNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTS 339 RNL++ +P +R T + HPWI T + + +H S Sbjct: 258 RNLMEKDPNKRYTCEQAARHPWIAGDTALNKN-IHES 293 >2W4O-A nrPDB Length = 349 Score = 191 bits (485), Expect = 5e-49, Method: Compositional matrix adjust. Identities = 111/296 (37%), Positives = 166/296 (56%), Gaps = 17/296 (5%) Query: 33 AQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFAL 92 A P P + + ++A+ D ++V S+ LG G V + K TQ+ +AL Sbjct: 28 ASAAPGTASLVPDYWIDGS---NRDALSDFFEVESE-LGRGATSIVYRCKQKGTQKPYAL 83 Query: 93 KMLQ---DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSR 149 K+L+ D R E+ + R S P+I+++ +++E + +V+E + GGELF R Sbjct: 84 KVLKKTVDKKIVRTEIGVLLRLSH-PNIIKLKEIFETPTE----ISLVLELVTGGELFDR 138 Query: 150 IQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFG 209 I ++G ++ER+A++ +K I EA+ YLH I HRD+KPENLLY + P+A LK+ DFG Sbjct: 139 IVEKG--YYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFG 196 Query: 210 FAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL 269 +K + T C TP Y APE+L Y DMWS+G+I YILLCG+ PFY G Sbjct: 197 LSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERG- 255 Query: 270 AISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 M RI +Y F +P W EVS K L+R L+ +P +R+T + + HPW+ Sbjct: 256 --DQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV 309 >4JG6-A nrPDB Length = 355 Score = 191 bits (484), Expect = 7e-49, Method: Compositional matrix adjust. Identities = 104/290 (35%), Positives = 169/290 (58%), Gaps = 13/290 (4%) Query: 53 QIKKNAI--IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKA-RREVELHW 109 Q+ +N+I D Y+V + G+G + +K T +FA+K++ + E+E+ Sbjct: 25 QLHRNSIQFTDGYEVKEDI-GVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILL 83 Query: 110 RASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 169 R Q P+I+ + DVY++ K + +V E + GGEL +I + + F+EREAS ++ + Sbjct: 84 RYGQHPNIITLKDVYDD----GKYVYVVTELMKGGELLDKILRQ--KFFSEREASAVLFT 137 Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPN-AILKLTDFGFAKETTSHNSL-TTPCYTP 227 I + ++YLH+ + HRD+KP N+LY + N +++ DFGFAK+ + N L TPCYT Sbjct: 138 ITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTA 197 Query: 228 YYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 +VAPEVL + YD +CD+WSLGV++Y +L GY PF +N + RI G++ Sbjct: 198 NFVAPEVLERQGYDAACDIWSLGVLLYTMLTGYTPF-ANGPDDTPEEILARIGSGKFSLS 256 Query: 288 NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLH 337 W+ VS+ K L+ +L +P QR+T + HPWI+ ++PQ L+ Sbjct: 257 GGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLN 306 >3KN6-A nrPDB Length = 325 Score = 183 bits (465), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 99/287 (34%), Positives = 165/287 (57%), Gaps = 12/287 (4%) Query: 62 DYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKA--RREVELHWRASQCPHIVR 119 D + + LG G + +K++ + FA+K++ +A ++E+ P+IV+ Sbjct: 11 DLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVK 70 Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 + +V+ + +VME L+GGELF RI+ + + F+E EAS IM+ + A+ ++H Sbjct: 71 LHEVFHDQLH----TFLVMELLNGGELFERIKKK--KHFSETEASYIMRKLVSAVSHMHD 124 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS-LTTPCYTPYYVAPEVLGPE 238 + + HRD+KPENLL+T + N +K+ DFGFA+ N L TPC+T +Y APE+L Sbjct: 125 VGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQN 184 Query: 239 KYDKSCDMWSLGVIMYILLCGYPPFYS-NHGLAISPGMKT--RIRMGQYEFPNPEWSEVS 295 YD+SCD+WSLGVI+Y +L G PF S + L + ++ +I+ G + F W VS Sbjct: 185 GYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVS 244 Query: 296 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVL 342 +E K LI+ LL +P +R+ ++ + W+ +++ PL T +L Sbjct: 245 QEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDIL 291 >3NCG-A nrPDB Length = 486 Score = 183 bits (464), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 114/340 (33%), Positives = 182/340 (53%), Gaps = 28/340 (8%) Query: 69 VLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQCPHIVRIV 121 +LG G G+VL+ ++ TQ+++A+K++ +D REVEL + P+I+++ Sbjct: 29 MLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDH-PNIMKLF 87 Query: 122 DVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN 181 ++ E+ IV E GGELF I R + F+E +A+ I+K + I Y+H N Sbjct: 88 EILED----SSSFYIVGELYTGGELFDEIIKR--KRFSEHDAARIIKQVFSGITYMHKHN 141 Query: 182 IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYD 241 I HRD+KPEN+L SK + +K+ DFG + + + T YY+APEVL YD Sbjct: 142 IVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRG-TYD 200 Query: 242 KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKML 301 + CD+WS GVI+YILL G PPFY + I R+ G+Y F P+W +S++ K L Sbjct: 201 EKCDVWSAGVILYILLSGTPPFYGKNEYDILK----RVETGKYAFDLPQWRTISDDAKDL 256 Query: 302 IRNLLKTEPTQRMTITEFMNHPWIMQ-STKVP--------QTPLHTSRVLKEDKERWEDV 352 IR +L P+ R+T T+ + HPWI + S++ P ++ + R + +K+ + Sbjct: 257 IRKMLTFHPSLRITATQCLEHPWIQKYSSETPTISDLPSLESAMTNIRQFQAEKKLAQAA 316 Query: 353 KEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARA 392 M S L T+ + +I + D +N +L R + R Sbjct: 317 LLYMASKLTTLDETKQLTEIFRKLDTNNDGMLDRDELVRG 356 >3HZT-A nrPDB Length = 467 Score = 183 bits (464), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 108/303 (35%), Positives = 165/303 (54%), Gaps = 35/303 (11%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQ--------DCPKARREVELHWRASQCPHIVRIV 121 LG G G+VL +K T + A+K+++ + EV + + P+I+++ Sbjct: 12 LGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAV-LKQLDHPNIMKLY 70 Query: 122 DVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN 181 + +E+ ++ +VME GGELF I R Q F+E +A+ IMK + YLH N Sbjct: 71 EFFED----KRNYYLVMEVYRGGELFDEIILR--QKFSEVDAAVIMKQVLSGTTYLHKHN 124 Query: 182 IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYD 241 I HRD+KPENLL SK +A++K+ DFG + + T YY+APEVL +KYD Sbjct: 125 IVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVL-RKKYD 183 Query: 242 KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKML 301 + CD+WS GVI+YILLCGYPPF G + R+ G++ F P+W++VS+E K L Sbjct: 184 EKCDVWSCGVILYILLCGYPPF----GGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQL 239 Query: 302 IRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALA 361 ++ +L EP++R++ E +NHPWI++ T + K +T AL Sbjct: 240 VKLMLTYEPSKRISAEEALNHPWIVKFCSQKHTDVG---------------KHALTGALG 284 Query: 362 TMR 364 M+ Sbjct: 285 NMK 287 >3DXN-A nrPDB Length = 287 Score = 182 bits (463), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 102/266 (38%), Positives = 156/266 (58%), Gaps = 20/266 (7%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQ--------DCPKARREVELHWRASQCPHIVRIV 121 LG G G+VL +K T + A+K+++ + EV + + P+I+++ Sbjct: 29 LGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAV-LKQLDHPNIMKLY 87 Query: 122 DVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN 181 + +E+ ++ +VME GGELF I R Q F+E +A+ IMK + YLH N Sbjct: 88 EFFED----KRNYYLVMEVYRGGELFDEIILR--QKFSEVDAAVIMKQVLSGTTYLHKHN 141 Query: 182 IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYD 241 I HRD+KPENLL SK +A++K+ DFG + + T YY+APEVL +KYD Sbjct: 142 IVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVL-RKKYD 200 Query: 242 KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKML 301 + CD+WS GVI+YILLCGYPPF G + R+ G++ F P+W++VS+E K L Sbjct: 201 EKCDVWSCGVILYILLCGYPPF----GGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQL 256 Query: 302 IRNLLKTEPTQRMTITEFMNHPWIMQ 327 ++ +L EP++R++ E +NHPWI++ Sbjct: 257 VKLMLTYEPSKRISAEEALNHPWIVK 282 >3LIJ-A nrPDB Length = 494 Score = 180 bits (456), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 99/263 (37%), Positives = 151/263 (57%), Gaps = 19/263 (7%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQDCP-------KARREVELHWRASQCPHIVRIVD 122 LG G G+VL +K T + A+K+++ K EV + + P+I+++ D Sbjct: 45 LGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAV-LKLLDHPNIMKLYD 103 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182 +E+ ++ +VMEC GGELF I R F E +A+ I+K + + YLH NI Sbjct: 104 FFED----KRNYYLVMECYKGGELFDEIIHR--MKFNEVDAAVIIKQVLSGVTYLHKHNI 157 Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDK 242 HRD+KPENLL SK +A++K+ DFG + + + T YY+APEVL +KYD+ Sbjct: 158 VHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEVL-RKKYDE 216 Query: 243 SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI 302 CD+WS+GVI++ILL GYPPF G + ++ G+Y F +PEW VSE K LI Sbjct: 217 KCDVWSIGVILFILLAGYPPF----GGQTDQEILRKVEKGKYTFDSPEWKNVSEGAKDLI 272 Query: 303 RNLLKTEPTQRMTITEFMNHPWI 325 + +L+ + +R++ + + HPWI Sbjct: 273 KQMLQFDSQRRISAQQALEHPWI 295 >3DFA-A nrPDB Length = 286 Score = 178 bits (452), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 100/266 (37%), Positives = 152/266 (57%), Gaps = 19/266 (7%) Query: 69 VLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQCPHIVRIV 121 +LG G G+VL+ ++ TQ+++A+K++ +D REVEL + P+I+++ Sbjct: 29 MLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDH-PNIMKLF 87 Query: 122 DVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN 181 ++ E+ IV E GGELF I R + F+E +A+ I+K + I Y+H N Sbjct: 88 EILED----SSSFYIVGELYTGGELFDEIIKR--KRFSEHDAARIIKQVFSGITYMHKHN 141 Query: 182 IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYD 241 I HRD+KPEN+L SK + +K+ DFG + + + T YY+APEVL YD Sbjct: 142 IVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRG-TYD 200 Query: 242 KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKML 301 + CD+WS GVI+YILL G PPFY + I R+ G+Y F P+W +S++ K L Sbjct: 201 EKCDVWSAGVILYILLSGTPPFYGKNEYDILK----RVETGKYAFDLPQWRTISDDAKDL 256 Query: 302 IRNLLKTEPTQRMTITEFMNHPWIMQ 327 IR +L P+ R+T T+ + HPWI + Sbjct: 257 IRKMLTFHPSLRITATQCLEHPWIQK 282 >3F3Z-A nrPDB Length = 277 Score = 176 bits (446), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 100/275 (36%), Positives = 151/275 (54%), Gaps = 25/275 (9%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALK-----MLQDCPKARREVELHWRASQC 114 I+ Y +G G G+V K T+ + A K ++D + ++E+E+ ++ Sbjct: 7 INQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDRFKQEIEIM-KSLDH 65 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 P+I+R+ + +E+ + +VME GGELF R+ + + F E +A+ IMK + A+ Sbjct: 66 PNIIRLYETFED----NTDIYLVMELCTGGELFERVVHK--RVFRESDAARIMKDVLSAV 119 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV 234 Y H +N+AHRD+KPEN L+ + P++ LKL DFG A + T TPYYV+P+V Sbjct: 120 AYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQV 179 Query: 235 L----GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE 290 L GPE CD WS GV+MY+LLCGYPPF + + +IR G + FP + Sbjct: 180 LEGLYGPE-----CDEWSAGVMMYVLLCGYPPFSA----PTDSEVMLKIREGTFTFPEKD 230 Query: 291 WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 W VS + + LIR LL P QR+T + + H W Sbjct: 231 WLNVSPQAESLIRRLLTKSPKQRITSLQALEHEWF 265 >5IG1-A nrPDB Length = 344 Score = 174 bits (441), Expect = 6e-44, Method: Compositional matrix adjust. Identities = 109/293 (37%), Positives = 159/293 (54%), Gaps = 20/293 (6%) Query: 62 DYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQC 114 D K V+G G V + NKRT E A+K++ + K +RE+ + + Q Sbjct: 17 DLKDKRSVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGI-CSSLQH 75 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 HIV + + + +V E + GGELF I R + + E++AS M I A+ Sbjct: 76 EHIVSMRRAFRD----ESHFYLVFEYVSGGELFDEIVTR--KFYNEKDASACMHQILSAL 129 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV 234 Q+ HS NI HRD+KPENLL SK PNA +K+TDFG A + TP Y++PEV Sbjct: 130 QHCHSKNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEV 189 Query: 235 LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 294 + YD + D+W+ GVI+YILL GYPPF+ + +I+ QY+FP+PEW V Sbjct: 190 IRRVPYDTAVDVWACGVILYILLVGYPPFWEED----HQKLYAQIKNCQYDFPSPEWDSV 245 Query: 295 SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKE 347 + K LI+ +L+ P +R T+ E + HPWI + VP + +H L+E K+ Sbjct: 246 TTAAKELIKAMLEPNPKRRPTVQELLQHPWIARR-DVPGS-VHRQATLEELKK 296 >5FG8-A nrPDB Length = 285 Score = 173 bits (438), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 105/280 (37%), Positives = 152/280 (54%), Gaps = 22/280 (7%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQ 113 D+Y + + LG G V + K T +FA K++ +D K RE + R Sbjct: 14 DNYDIKEE-LGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARI-CRKLH 71 Query: 114 CPHIVRIVD-VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 P+IVR+ D + E Y +V + + GGELF I R + ++E +AS ++ I E Sbjct: 72 HPNIVRLHDSIQEENYH-----YLVFDLVTGGELFEDIVAR--EFYSEADASHCIQQILE 124 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS-HNSLTTPCYTPYYVA 231 ++ + H + HRD+KPENLL SK A +KL DFG A E H + TP Y++ Sbjct: 125 SVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLS 184 Query: 232 PEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW 291 PEVL E Y KS D+W+ GVI+YILL GYPPF+ + ++I+ G Y++P+PEW Sbjct: 185 PEVLKKEPYGKSVDIWACGVILYILLVGYPPFWDED----QHRLYSQIKAGAYDYPSPEW 240 Query: 292 SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKV 331 V+ E K LI +L P +R+T E + HPWI Q +V Sbjct: 241 DTVTPEAKNLINQMLTVNPNKRITAAEALKHPWICQRERV 280 >2HW6-A nrPDB Length = 307 Score = 172 bits (436), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 100/294 (34%), Positives = 160/294 (54%), Gaps = 35/294 (11%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-----DCPKARREVELHWRASQCP 115 D YK+TS++LG G KV + + +++A+K+++ + REVE ++ Sbjct: 12 DMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNK 71 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 +I+ +++ +E+ +V E L GG + + IQ + + F EREAS +++ + A+ Sbjct: 72 NILELIEFFED----DTRFYLVFEKLQGGSILAHIQKQ--KHFNEREASRVVRDVAAALD 125 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--------LTTPCYTP 227 +LH+ IAHRD+KPEN+L S + +K+ DF +NS LTTPC + Sbjct: 126 FLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSA 185 Query: 228 YYVAPEVL-----GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHG--LAISPGMKTR-- 278 Y+APEV+ YDK CD+WSLGV++YI+L GYPPF + G G R Sbjct: 186 EYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVC 245 Query: 279 -------IRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 I+ G+YEFP+ +W+ +S E K LI LL + QR++ + + HPW+ Sbjct: 246 QNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV 299 >5JN2-A nrPDB Length = 525 Score = 169 bits (428), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 106/331 (32%), Positives = 161/331 (48%), Gaps = 29/331 (8%) Query: 8 QSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTS 67 Q + A P + P P F Q AI D Sbjct: 22 QESTLGGAAGEPRSRGHAAGTSGGPGDHLHATPGMFVQ---------HSTAIFSDRYKGQ 72 Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQ--------DCPKARREVELHWRASQCPHIVR 119 +VLG G G+V+ +K T ++ A+K++ D REV+L + P+I++ Sbjct: 73 RVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQL-LKQLDHPNIMK 131 Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 + + +E+ + +V E GGELF I R + F+E +A+ I++ + I Y+H Sbjct: 132 LYEFFED----KGYFYLVGEVYTGGELFDEIISR--KRFSEVDAARIIRQVLSGITYMHK 185 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEK 239 I HRD+KPENLL SK +A +++ DFG + + + T YY+APEVL Sbjct: 186 NKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHG-T 244 Query: 240 YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVK 299 YD+ CD+WS GVI+YILL G PPF + I ++ G+Y F P+W +VSE K Sbjct: 245 YDEKCDVWSTGVILYILLSGCPPFNGANEYDILK----KVEKGKYTFELPQWKKVSESAK 300 Query: 300 MLIRNLLKTEPTQRMTITEFMNHPWIMQSTK 330 LIR +L P+ R++ + ++H WI TK Sbjct: 301 DLIRKMLTYVPSMRISARDALDHEWIQTYTK 331 >5JZN-A nrPDB Length = 280 Score = 167 bits (423), Expect = 7e-42, Method: Compositional matrix adjust. Identities = 106/286 (37%), Positives = 154/286 (53%), Gaps = 24/286 (8%) Query: 49 KSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELH 108 + G QI I + YKV + +G G V + + T ++ALK+++ +E + Sbjct: 8 EEGFQIPAT-ITERYKV-GRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQ 65 Query: 109 -----WRASQCPHIVRIV---DVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTE 160 R + P+IV ++ DV LY +VME + GG+LF I +TE Sbjct: 66 NEVSILRRVKHPNIVLLIEEMDVPTELY-------LVMELVKGGDLFDAITST--NKYTE 116 Query: 161 REASEIMKSIGEAIQYLHSINIAHRDVKPENLL-YTSKRPNAILKLTDFGFAKETTSHNS 219 R+AS ++ ++ AI+YLHS+NI HRD+KPENLL Y + + LKL DFG A T Sbjct: 117 RDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLA--TIVDGP 174 Query: 220 LTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRI 279 L T C TP YVAPE++ Y D+W+ GVI YILLCG+PPF + + +I Sbjct: 175 LYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSG--DDQEVLFDQI 232 Query: 280 RMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 MGQ +FP+P W VS+ K LI +L + QR + + + HPW+ Sbjct: 233 LMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWV 278 >3KK8-A nrPDB Length = 284 Score = 167 bits (422), Expect = 9e-42, Method: Compositional matrix adjust. Identities = 102/278 (36%), Positives = 149/278 (53%), Gaps = 19/278 (6%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQ 113 D+Y V + LG G V + +K T +FA K++ +D K RE + R Q Sbjct: 6 DNYDVKEE-LGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARI-CRKLQ 63 Query: 114 CPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEA 173 P+IVR+ D + +V + + GGELF I R + ++E +AS ++ I E+ Sbjct: 64 HPNIVRLHDSIQE----ESFHYLVFDLVTGGELFEDIVAR--EFYSEADASHCIQQILES 117 Query: 174 IQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPE 233 I Y HS I HR++KPENLL SK A +KL DFG A E + TP Y++PE Sbjct: 118 IAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPE 177 Query: 234 VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSE 293 VL + Y K D+W+ GVI+YILL GYPPF+ + +I+ G Y++P+PEW Sbjct: 178 VLKKDPYSKPVDIWACGVILYILLVGYPPFWDED----QHRLYAQIKAGAYDYPSPEWDT 233 Query: 294 VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKV 331 V+ E K LI ++L P +R+T + + PWI +V Sbjct: 234 VTPEAKSLIDSMLTVNPKKRITADQALKVPWICNRERV 271 >2BDW-A nrPDB Length = 362 Score = 167 bits (422), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 102/278 (36%), Positives = 149/278 (53%), Gaps = 19/278 (6%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQ 113 D+Y V + LG G V + +K T +FA K++ +D K RE + R Q Sbjct: 29 DNYDVKEE-LGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARI-CRKLQ 86 Query: 114 CPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEA 173 P+IVR+ D + +V + + GGELF I R + ++E +AS ++ I E+ Sbjct: 87 HPNIVRLHDSIQE----ESFHYLVFDLVTGGELFEDIVAR--EFYSEADASHCIQQILES 140 Query: 174 IQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPE 233 I Y HS I HR++KPENLL SK A +KL DFG A E + TP Y++PE Sbjct: 141 IAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPE 200 Query: 234 VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSE 293 VL + Y K D+W+ GVI+YILL GYPPF+ + +I+ G Y++P+PEW Sbjct: 201 VLKKDPYSKPVDIWACGVILYILLVGYPPFWDED----QHRLYAQIKAGAYDYPSPEWDT 256 Query: 294 VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKV 331 V+ E K LI ++L P +R+T + + PWI +V Sbjct: 257 VTPEAKSLIDSMLTVNPKKRITADQALKVPWICNRERV 294 >2YCR-A nrPDB Length = 323 Score = 166 bits (419), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 103/286 (36%), Positives = 160/286 (55%), Gaps = 32/286 (11%) Query: 58 AIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD----CPKARR---------E 104 A+ D+Y + S+ LG G G+V F ++T +K A+K++ AR E Sbjct: 7 ALRDEY-IMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETE 65 Query: 105 VELHWRASQCPHIVRIVDVY--ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTERE 162 +E+ + + P I++I + + E+ Y IV+E ++GGELF ++ G++ E Sbjct: 66 IEILKKLNH-PCIIKIKNFFDAEDYY-------IVLELMEGGELFDKVV--GNKRLKEAT 115 Query: 163 ASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTT 222 + A+QYLH I HRD+KPEN+L +S+ + ++K+TDFG +K + + T Sbjct: 116 CKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRT 175 Query: 223 PCYTPYYVAPEVL---GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRI 279 C TP Y+APEVL G Y+++ D WSLGVI++I L GYPPF S H +S +K +I Sbjct: 176 LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPF-SEHRTQVS--LKDQI 232 Query: 280 RMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 G+Y F W+EVSE+ L++ LL +P R T E + HPW+ Sbjct: 233 TSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 278 >3Q5I-A nrPDB Length = 504 Score = 166 bits (419), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 87/211 (41%), Positives = 124/211 (58%), Gaps = 11/211 (5%) Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 P+I+++ DV+E+ +K +V E +GGELF +I +R F E +A+ IMK I I Sbjct: 106 PNIIKLFDVFED----KKYFYLVTEFYEGGELFEQIINR--HKFDECDAANIMKQILSGI 159 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV 234 YLH NI HRD+KPEN+L +K +K+ DFG + + L T YY+APEV Sbjct: 160 CYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTAYYIAPEV 219 Query: 235 LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 294 L +KY++ CD+WS GVIMYILLCGYPPF G + ++ G+Y F +W + Sbjct: 220 L-KKKYNEKCDVWSCGVIMYILLCGYPPF----GGQNDQDIIKKVEKGKYYFDFNDWKNI 274 Query: 295 SEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 S+E K LI+ +L + +R T E +N WI Sbjct: 275 SDEAKELIKLMLTYDYNKRCTAEEALNSRWI 305 >3MA6-A nrPDB Length = 298 Score = 165 bits (417), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 99/282 (35%), Positives = 152/282 (53%), Gaps = 20/282 (7%) Query: 57 NAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ--------DCPKARREVELH 108 AI D +VLG G G+V+ +K T ++ A+K++ D REV+L Sbjct: 27 TAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQL- 85 Query: 109 WRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMK 168 + P+I+++ + +E+ + +V E GGELF I R + F+E +A+ I++ Sbjct: 86 LKQLDHPNIMKLYEFFED----KGYFYLVGEVYTGGELFDEIISR--KRFSEVDAARIIR 139 Query: 169 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY 228 + I Y+H I HRD+KPENLL SK +A +++ DFG + + + T Y Sbjct: 140 QVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAY 199 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN 288 Y+APEVL YD+ CD+WS GVI+YILL G PPF + I ++ G+Y F Sbjct: 200 YIAPEVLHG-TYDEKCDVWSTGVILYILLSGCPPFNGANEYDILK----KVEKGKYTFEL 254 Query: 289 PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTK 330 P+W +VSE K LIR +L P+ R++ + ++H WI TK Sbjct: 255 PQWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTK 296 >3I6U-A nrPDB Length = 419 Score = 162 bits (411), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 102/286 (35%), Positives = 160/286 (55%), Gaps = 32/286 (11%) Query: 58 AIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD----CPKARR---------E 104 A+ D+Y + S+ LG G G+V F ++T +K A++++ AR E Sbjct: 132 ALRDEY-IMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETE 190 Query: 105 VELHWRASQCPHIVRIVDVY--ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTERE 162 +E+ + + P I++I + + E+ Y IV+E ++GGELF ++ G++ E Sbjct: 191 IEILKKLNH-PCIIKIKNFFDAEDYY-------IVLELMEGGELFDKVV--GNKRLKEAT 240 Query: 163 ASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTT 222 + A+QYLH I HRD+KPEN+L +S+ + ++K+TDFG +K + + T Sbjct: 241 CKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRT 300 Query: 223 PCYTPYYVAPEVL---GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRI 279 C TP Y+APEVL G Y+++ D WSLGVI++I L GYPPF S H +S +K +I Sbjct: 301 LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPF-SEHRTQVS--LKDQI 357 Query: 280 RMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 G+Y F W+EVSE+ L++ LL +P R T E + HPW+ Sbjct: 358 TSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 403 >2VN9-A nrPDB Length = 301 Score = 162 bits (410), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 102/283 (36%), Positives = 154/283 (54%), Gaps = 22/283 (7%) Query: 58 AIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWR 110 ++ D+Y++ + LG G V + T +++A K++ +D K RE + R Sbjct: 1 SMTDEYQLFEE-LGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARI-CR 58 Query: 111 ASQCPHIVRIVD-VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 169 + P+IVR+ D + E + +V + + GGELF I R + ++E +AS ++ Sbjct: 59 LLKHPNIVRLHDSISEEGFH-----YLVFDLVTGGELFEDIVAR--EYYSEADASHCIQQ 111 Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS-HNSLTTPCYTPY 228 I E++ + H I HRD+KPENLL SK A +KL DFG A E + TP Sbjct: 112 ILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPG 171 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN 288 Y++PEVL + Y K DMW+ GVI+YILL GYPPF+ + +I+ G Y+FP+ Sbjct: 172 YLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDED----QHRLYQQIKAGAYDFPS 227 Query: 289 PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKV 331 PEW V+ E K LI +L P +R+T +E + HPWI Q + V Sbjct: 228 PEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTV 270 >2V7O-A nrPDB Length = 336 Score = 161 bits (407), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 100/280 (35%), Positives = 152/280 (54%), Gaps = 22/280 (7%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQ 113 DDY++ + LG G V + K +++A K++ +D K RE + R + Sbjct: 31 DDYQLFEE-LGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARI-CRLLK 88 Query: 114 CPHIVRIVD-VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 P+IVR+ D + E + +V + + GGELF I R + ++E +AS + I E Sbjct: 89 HPNIVRLHDSISEEGFH-----YLVFDLVTGGELFEDIVAR--EYYSEADASHCIHQILE 141 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS-HNSLTTPCYTPYYVA 231 ++ ++H +I HRD+KPENLL SK A +KL DFG A E + TP Y++ Sbjct: 142 SVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLS 201 Query: 232 PEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW 291 PEVL + Y K D+W+ GVI+YILL GYPPF+ + +I+ G Y+FP+PEW Sbjct: 202 PEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDED----QHKLYQQIKAGAYDFPSPEW 257 Query: 292 SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKV 331 V+ E K LI +L P +R+T + + HPW+ Q + V Sbjct: 258 DTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTV 297 >4YZB-A nrPDB Length = 491 Score = 160 bits (406), Expect = 6e-40, Method: Compositional matrix adjust. Identities = 98/305 (32%), Positives = 161/305 (52%), Gaps = 31/305 (10%) Query: 35 PPPPPPQQFPQFHVKSGLQIKKN--AIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFAL 92 P P + + G+ ++ + A D YK +VLG G G+V+ +K T +++A+ Sbjct: 2 PGSPAASKSDKLAATPGMFVQHSTAAFSDRYK-GQRVLGKGSFGEVILCKDKVTGQEYAV 60 Query: 93 KMLQDCPKARREVE------------LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMEC 140 K++ ++R+V+ + P+I+++ + +E+ + +V E Sbjct: 61 KVI-----SKRQVKQKTDKELLLKEVELLKKLDHPNIMKLYEFFED----KGYFYLVTEV 111 Query: 141 LDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPN 200 GGELF I R + F+E +A+ I++ + I Y+H I HRD+KPENLL +KR + Sbjct: 112 YTGGELFDEIISR--KRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKD 169 Query: 201 AILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGY 260 A +++ DFG + S + T YY+APEVL YD+ CD+WS GVI+YILL G Sbjct: 170 ANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHG-TYDEKCDVWSTGVILYILLSGC 228 Query: 261 PPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM 320 PPF + I ++ G++ F P+W +VSE K LIR +L PT R++ + + Sbjct: 229 PPFNGANEFDILK----KVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDAL 284 Query: 321 NHPWI 325 H W+ Sbjct: 285 EHEWL 289 >2Y7J-A nrPDB Length = 365 Score = 159 bits (403), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 91/276 (32%), Positives = 147/276 (53%), Gaps = 32/276 (11%) Query: 69 VLGLGINGKVLQIFNKRTQEKFALKMLQDCPK-------------ARREVELHWRASQCP 115 V+G G++ V + ++ T +FA+K+++ + RRE + + + P Sbjct: 101 VIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHP 160 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 HI+ ++D YE+ + +V + + GELF + ++ A +E+E IM+S+ EA+ Sbjct: 161 HIITLIDSYES----SSFMFLVFDLMRKGELFDYLTEK--VALSEKETRSIMRSLLEAVS 214 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL 235 +LH+ NI HRD+KPEN+L N ++L+DFGF+ L C TP Y+APE+L Sbjct: 215 FLHANNIVHRDLKPENILLDD---NMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEIL 271 Query: 236 GPE------KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNP 289 Y K D+W+ GVI++ LL G PPF+ + M I GQY+F +P Sbjct: 272 KCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQIL----MLRMIMEGQYQFSSP 327 Query: 290 EWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 EW + S VK LI LL+ +P R+T + + HP+ Sbjct: 328 EWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFF 363 >3BHH-A nrPDB Length = 295 Score = 159 bits (401), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 99/284 (34%), Positives = 151/284 (53%), Gaps = 22/284 (7%) Query: 58 AIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWR 110 ++ D+Y++ + G G V + T ++A K++ +D K RE + R Sbjct: 1 SMTDEYQLYEDI-GKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARI-CR 58 Query: 111 ASQCPHIVRIVD-VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 169 + +IVR+ D + E + +V + + GGELF I R + ++E +AS ++ Sbjct: 59 LLKHSNIVRLHDSISEEGFH-----YLVFDLVTGGELFEDIVAR--EYYSEADASHCIQQ 111 Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS-HNSLTTPCYTPY 228 I EA+ + H + + HRD+KPENLL SK A +KL DFG A E + TP Sbjct: 112 ILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPG 171 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN 288 Y++PEVL E Y K D+W+ GVI+YILL GYPPF+ + +I+ G Y+FP+ Sbjct: 172 YLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDED----QHKLYQQIKAGAYDFPS 227 Query: 289 PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVP 332 PEW V+ E K LI +L P +R+T E + HPW+ Q + V Sbjct: 228 PEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVA 271 >6CKI-A nrPDB Length = 316 Score = 157 bits (398), Expect = 6e-39, Method: Compositional matrix adjust. Identities = 105/314 (33%), Positives = 158/314 (50%), Gaps = 41/314 (13%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP-----KARREVELHWRASQCP 115 D Y++ VLG G + +V N T +++A+K+++ P + REVE+ + QC Sbjct: 12 DVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLY---QCQ 68 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 R V + +V E + GG + S I R + F E EAS +++ + A+ Sbjct: 69 G-HRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKR--RHFNELEASVVVQDVASALD 125 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAI--LKLTDFGFAKETTSHNS--------LTTPCY 225 +LH+ IAHRD+KPEN+L + PN + +K+ DFG + L TPC Sbjct: 126 FLHNKGIAHRDLKPENIL--CEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCG 183 Query: 226 TPYYVAPEVLGP-----EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL----------- 269 + Y+APEV+ YDK CD+WSLGVI+YILL GYPPF G Sbjct: 184 SAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACP 243 Query: 270 AISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQST 329 A + I+ G+YEFP+ +W+ +S K LI LL + QR++ + + HPW+ Sbjct: 244 ACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCA 303 Query: 330 KVPQTPLHTSRVLK 343 P+ L T VL+ Sbjct: 304 --PENTLPTPMVLQ 315 >2VZ6-A nrPDB Length = 313 Score = 157 bits (396), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 97/270 (35%), Positives = 143/270 (52%), Gaps = 19/270 (7%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQCPHIVRIVD 122 LG G V + +++A K++ +D K RE + R + P+IVR+ D Sbjct: 30 LGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARI-CRLLKHPNIVRLHD 88 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182 G L + + + GGELF I R + ++E +AS ++ I EA+ + H + + Sbjct: 89 SISE--EGHHYL--IFDLVTGGELFEDIVAR--EYYSEADASHCIQQILEAVLHCHQMGV 142 Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS-HNSLTTPCYTPYYVAPEVLGPEKYD 241 HRD+KPENLL SK A +KL DFG A E + TP Y++PEVL + Y Sbjct: 143 VHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYG 202 Query: 242 KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKML 301 K D+W+ GVI+YILL GYPPF+ + +I+ G Y+FP+PEW V+ E K L Sbjct: 203 KPVDLWACGVILYILLVGYPPFWDED----QHRLYQQIKAGAYDFPSPEWDTVTPEAKDL 258 Query: 302 IRNLLKTEPTQRMTITEFMNHPWIMQSTKV 331 I +L P++R+T E + HPWI + V Sbjct: 259 INKMLTINPSKRITAAEALKHPWISHRSTV 288 >5U6Y-A nrPDB Length = 461 Score = 156 bits (394), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 106/304 (34%), Positives = 158/304 (51%), Gaps = 23/304 (7%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQCPHIVRIVD 122 LG G V + +++A K++ +D K RE + R + P+IVR+ D Sbjct: 8 LGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARI-CRLLKHPNIVRLHD 66 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182 G L + + + GGELF I R + ++E +AS ++ I EA+ + H + + Sbjct: 67 SISE--EGHHYL--IFDLVTGGELFEDIVAR--EYYSEADASHCIQQILEAVLHCHQMGV 120 Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS-HNSLTTPCYTPYYVAPEVLGPEKYD 241 HRD+KPENLL SK A +KL DFG A E + TP Y++PEVL + Y Sbjct: 121 VHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYG 180 Query: 242 KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKML 301 K D+W+ GVI+YILL GYPPF+ + +I+ G Y+FP+PEW V+ E K L Sbjct: 181 KPVDLWACGVILYILLVGYPPFWDED----QHRLYQQIKAGAYDFPSPEWDTVTPEAKDL 236 Query: 302 IRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLH---TSRVLKEDKERWEDVKEEMTS 358 I +L P++R+T E + HPWI + V + +H T LK+ R + +T+ Sbjct: 237 INKMLTINPSKRITAAEALKHPWISHRSTVA-SCMHRQETVDCLKKFNARRKLKGAILTT 295 Query: 359 ALAT 362 LAT Sbjct: 296 MLAT 299 >3SOA-A nrPDB Length = 444 Score = 154 bits (389), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 101/286 (35%), Positives = 151/286 (52%), Gaps = 16/286 (5%) Query: 96 QDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGD 155 +D K RE + R + P+IVR+ D G L + + + GGELF I R Sbjct: 52 RDHQKLEREARI-CRLLKHPNIVRLHDSISE--EGHHYL--IFDLVTGGELFEDIVAR-- 104 Query: 156 QAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT 215 + ++E +AS ++ I EA+ + H + + HR++KPENLL SK A +KL DFG A E Sbjct: 105 EYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVE 164 Query: 216 S-HNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPG 274 + TP Y++PEVL + Y K D+W+ GVI+YILL GYPPF+ Sbjct: 165 GEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDED----QHR 220 Query: 275 MKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQT 334 + +I+ G Y+FP+PEW V+ E K LI +L P++R+T E + HPWI + V + Sbjct: 221 LYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVA-S 279 Query: 335 PLH---TSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIED 377 +H T LK+ R + +T LAT + +I K+ + Sbjct: 280 CMHRQETVDCLKKFNARRKLKGAILTVMLATRNFSVRKQEIIKVTE 325 >3TAC-A nrPDB Length = 361 Score = 154 bits (389), Expect = 7e-38, Method: Compositional matrix adjust. Identities = 102/300 (34%), Positives = 152/300 (50%), Gaps = 31/300 (10%) Query: 48 VKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-----DCPKAR 102 V G + + +D +V+G G V + N+ T ++FA+K++ P Sbjct: 12 VPRGSMADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLS 71 Query: 103 REVELHWRASQC-----PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQA 157 E +L AS C PHIV +++ Y + L +V E +DG +L I R D Sbjct: 72 TE-DLKREASICHMLKHPHIVELLETYSS----DGMLYMVFEFMDGADLCFEIVKRADAG 126 Query: 158 F--TEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT 215 F +E AS M+ I EA++Y H NI HRDVKP +L SK +A +KL FG A + Sbjct: 127 FVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLG 186 Query: 216 SHNSLTTP-CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPG 274 + TP+++APEV+ E Y K D+W GVI++ILL G PFY G Sbjct: 187 ESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFY---------G 237 Query: 275 MKTR----IRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTK 330 K R I G+Y+ +WS +SE K L+R +L +P +R+T+ E +NHPW+ + + Sbjct: 238 TKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDR 297 >1PHK-A nrPDB Length = 298 Score = 150 bits (379), Expect = 9e-37, Method: Compositional matrix adjust. Identities = 93/280 (33%), Positives = 148/280 (52%), Gaps = 33/280 (11%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKML-------------QDCPKAR-REVELHWRASQ 113 ++LG G++ V + +K T +++A+K++ Q+ +A +EV++ + S Sbjct: 23 EILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDILRKVSG 82 Query: 114 CPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEA 173 P+I+++ D YE +V + + GELF + ++ +E+E +IM+++ E Sbjct: 83 HPNIIQLKDTYET----NTFFFLVFDLMKKGELFDYLTEK--VTLSEKETRKIMRALLEV 136 Query: 174 IQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPE 233 I LH +NI HRD+KPEN+L + +KLTDFGF+ + L C TP Y+APE Sbjct: 137 ICALHKLNIVHRDLKPENILLDD---DMNIKLTDFGFSCQLDPGEKLREVCGTPSYLAPE 193 Query: 234 VLGPE------KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 ++ Y K DMWS GVIMY LL G PPF+ + M I G Y+F Sbjct: 194 IIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQML----MLRMIMSGNYQFG 249 Query: 288 NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 +PEW + S+ VK L+ L +P +R T E + HP+ Q Sbjct: 250 SPEWDDYSDTVKDLVSRFLVVQPQKRYTAEEALAHPFFQQ 289 >3GUB-A nrPDB Length = 295 Score = 150 bits (378), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 93/277 (33%), Positives = 141/277 (50%), Gaps = 21/277 (7%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD--CPKARREVELH--------W 109 +DDY T + LG G V + K T ++A K ++ +RR V Sbjct: 9 VDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSIL 68 Query: 110 RASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 169 + Q P+++ + +VYEN + ++++ E + GGELF + ++ ++ TE EA+E +K Sbjct: 69 KEIQHPNVITLHEVYEN----KTDVILIGELVAGGELFDFLAEK--ESLTEEEATEFLKQ 122 Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKR-PNAILKLTDFGFAKETTSHNSLTTPCYTPY 228 I + YLHS+ IAH D+KPEN++ + P +K+ DFG A + N TP Sbjct: 123 ILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPE 182 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN 288 +VAPE++ E DMWS+GVI YILL G PF + + YEF + Sbjct: 183 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGD----TKQETLANVSAVNYEFED 238 Query: 289 PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 +S S K IR LL +P +RMTI + + HPWI Sbjct: 239 EYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWI 275 >2J90-A nrPDB Length = 304 Score = 149 bits (377), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 93/279 (33%), Positives = 145/279 (51%), Gaps = 21/279 (7%) Query: 58 AIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD--CPKARREVELH------- 108 ++++D+ + LG G V + K T +++A K ++ +RR V Sbjct: 22 SMVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVN 81 Query: 109 -WRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIM 167 R + P+I+ + D++EN + +++++E + GGELF + ++ ++ TE EA++ + Sbjct: 82 ILREIRHPNIITLHDIFEN----KTDVVLILELVSGGELFDFLAEK--ESLTEDEATQFL 135 Query: 168 KSIGEAIQYLHSINIAHRDVKPENLLYTSKR-PNAILKLTDFGFAKETTSHNSLTTPCYT 226 K I + + YLHS IAH D+KPEN++ K PN +KL DFG A + + N T Sbjct: 136 KQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGT 195 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286 P +VAPE++ E DMWS+GVI YILL G PF T I Y+F Sbjct: 196 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGE----TKQETLTNISAVNYDF 251 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 +S SE K IR LL +P +RMTI + + H WI Sbjct: 252 DEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWI 290 >4RGJ-A nrPDB Length = 520 Score = 148 bits (373), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 92/271 (33%), Positives = 142/271 (52%), Gaps = 21/271 (7%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQ--------DCPKARREVELHWRASQCPHIVR 119 ++LG G G+V+ +K T ++A+K++ D REVEL HI Sbjct: 66 KILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVEL---LKMLDHI-N 121 Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 I+ +YE + +V + GGELF I R + F E +A+ I+K I I Y+H Sbjct: 122 IMKLYE-FFEDNNYYYLVSDVYTGGELFDEIISR--KRFYEIDAARIIKQILSGITYMHK 178 Query: 180 INIAHRDVKPEN-LLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPE 238 N+ HRD+KPEN LL T + + I+K+ DFG + + T YY+AP+VL Sbjct: 179 NNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHG- 237 Query: 239 KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEV 298 YD+ CD+WS GVI+YILL G PPF ++ I ++ G+Y F P++ ++S++ Sbjct: 238 TYDEKCDIWSCGVILYILLSGCPPFNGSNEYDILK----KVEAGKYTFDLPQFKKISDKA 293 Query: 299 KMLIRNLLKTEPTQRMTITEFMNHPWIMQST 329 K LI+ +L R++ + + H WI T Sbjct: 294 KDLIKKMLMYTSAVRISARDALEHEWIKMMT 324 >5XZW-A nrPDB Length = 471 Score = 147 bits (370), Expect = 9e-36, Method: Compositional matrix adjust. Identities = 95/300 (31%), Positives = 157/300 (52%), Gaps = 33/300 (11%) Query: 50 SGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ------DCPKARR 103 S + K I D+ + +V+G G V + + T + FA+K++ + R Sbjct: 184 SSMVANKTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTR 243 Query: 104 EVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREA 163 E+E+ + + P IVR+ YE+ + +VME + GG+L + G A E Sbjct: 244 ELEVLQKLNH-PRIVRLKGFYED----TESYYMVMEFVSGGDLMDFVAAHG--AVGEDAG 296 Query: 164 SEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTP 223 EI + I AI+Y+HS+ I+HRD+KP+N+L P ++K+TDFG AK + + + T Sbjct: 297 REISRQILTAIKYIHSMGISHRDLKPDNILIEQDDP-VLVKITDFGLAKVQGNGSFMKTF 355 Query: 224 CYTPYYVAPEVL-------GPEKYDKS------CDMWSLGVIMYILLCGYPPFYSNHGLA 270 C T YVAPEV+ P++Y++ DMWS+G ++Y++L G+ PF + Sbjct: 356 CGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSG----S 411 Query: 271 ISPGMKTRIRMGQY-EFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQST 329 + +I G Y E P ++ +SEE + I +LL+ +P R T + +NHPWI+ S+ Sbjct: 412 TQDQLYKQIGRGSYHEGPLKDF-RISEEARDFIDSLLQVDPNNRSTAAKALNHPWIVDSS 470 >2YAB-A nrPDB Length = 361 Score = 143 bits (360), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 96/287 (33%), Positives = 143/287 (49%), Gaps = 23/287 (8%) Query: 51 GLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD----------C-P 99 G++ K ++D+ + LG G V + K T ++A K ++ C Sbjct: 1 GMETFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCRE 60 Query: 100 KARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFT 159 + REV + R P+I+ + DVYEN R +++++E + GGELF + + ++ + Sbjct: 61 EIEREVSI-LRQVLHPNIITLHDVYEN----RTDVVLILELVSGGELFDFLAQK--ESLS 113 Query: 160 EREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKR-PNAILKLTDFGFAKETTSHN 218 E EA+ +K I + + YLH+ IAH D+KPEN++ K P +KL DFG A E Sbjct: 114 EEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGV 173 Query: 219 SLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTR 278 TP +VAPE++ E DMWS+GVI YILL G PF + Sbjct: 174 EFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGD----TKQETLAN 229 Query: 279 IRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 I Y+F +S+ SE K IR LL E +R+TI E + HPWI Sbjct: 230 ITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWI 276 >4PDS-A nrPDB Length = 347 Score = 142 bits (358), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 93/299 (31%), Positives = 154/299 (51%), Gaps = 33/299 (11%) Query: 50 SGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ------DCPKARR 103 S + K I D+ + +V+G G V + + T + F++K++ + R Sbjct: 19 SSMVANKTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTR 78 Query: 104 EVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREA 163 E+E+ + + P IVR+ YE+ + +VME + GG+L + G A E Sbjct: 79 ELEVLQKLNH-PRIVRLKGFYEDT----ESYYMVMEFVSGGDLMDFVAAHG--AVGEDAG 131 Query: 164 SEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTP 223 EI + I AI+Y+HS+ I+HRD+KP+N+L P ++K+T FG AK + + + T Sbjct: 132 REISRQILTAIKYIHSMGISHRDLKPDNILIEQDDP-VLVKITAFGLAKVQGNGSFMKTF 190 Query: 224 CYTPYYVAPEVL-------GPEKYDKS------CDMWSLGVIMYILLCGYPPFYSNHGLA 270 C T YVAPEV+ P++Y++ DMWS+G ++Y++L G+ PF + Sbjct: 191 CGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSG----S 246 Query: 271 ISPGMKTRIRMGQY-EFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328 + +I G Y E P ++ +SEE + I +LL+ +P R T + +NHPWI S Sbjct: 247 TQDQLYKQIGRGSYHEGPLKDF-RISEEARDFIDSLLQVDPNNRSTAAKALNHPWIKMS 304 >1KOA-A nrPDB Length = 491 Score = 141 bits (356), Expect = 5e-34, Method: Compositional matrix adjust. Identities = 86/279 (30%), Positives = 142/279 (50%), Gaps = 17/279 (6%) Query: 52 LQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-----QDCPKARREVE 106 ++IK + ++D Y + + LG G G V ++ + T FA K + D R+E++ Sbjct: 42 VEIKHDHVLDHYDIHEE-LGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQ 100 Query: 107 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 + P +V + D +E+ ++++ E + GGELF ++ D ++ +E EA E Sbjct: 101 T-MSVLRHPTLVNLHDAFED----DNEMVMIYEFMSGGELFEKVADEHNK-MSEDEAVEY 154 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 226 M+ + + + ++H N H D+KPEN+++T+KR N LKL DFG S+ T Sbjct: 155 MRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNE-LKLIDFGLTAHLDPKQSVKVTTGT 213 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286 + APEV + DMWS+GV+ YILL G PF G ++ + Sbjct: 214 AEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPF----GGENDDETLRNVKSCDWNM 269 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 + +S +SE+ K IR LL +P RMTI + + HPW+ Sbjct: 270 DDSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWL 308 >3UTO-A nrPDB Length = 573 Score = 141 bits (355), Expect = 5e-34, Method: Compositional matrix adjust. Identities = 86/279 (30%), Positives = 142/279 (50%), Gaps = 17/279 (6%) Query: 52 LQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-----QDCPKARREVE 106 ++IK + ++D Y + + LG G G V ++ + T FA K + D R+E++ Sbjct: 148 VEIKHDHVLDHYDIHEE-LGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQ 206 Query: 107 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 + P +V + D +E+ ++++ E + GGELF ++ D ++ +E EA E Sbjct: 207 T-MSVLRHPTLVNLHDAFED----DNEMVMIYEFMSGGELFEKVADEHNK-MSEDEAVEY 260 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 226 M+ + + + ++H N H D+KPEN+++T+KR N LKL DFG S+ T Sbjct: 261 MRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNE-LKLIDFGLTAHLDPKQSVKVTTGT 319 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286 + APEV + DMWS+GV+ YILL G PF G ++ + Sbjct: 320 AEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPF----GGENDDETLRNVKSCDWNM 375 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 + +S +SE+ K IR LL +P RMTI + + HPW+ Sbjct: 376 DDSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWL 414 >2X4F-A nrPDB Length = 373 Score = 139 bits (351), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 104/347 (29%), Positives = 170/347 (48%), Gaps = 35/347 (10%) Query: 19 PPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVT-SQVLGLGINGK 77 P T AL A P PP F V + K+ A+ Y V+ +++LG G G+ Sbjct: 53 PVKSKRTSAL----AVDIPAPPAPFDHRIVTA----KQGAVNSFYTVSKTEILGGGRFGQ 104 Query: 78 VLQIFNKRTQEKFALKM-----LQDCPKARREVELHWRASQCPH--IVRIVDVYENLYAG 130 V + T K A K+ ++D + + E+ + +Q H ++++ D +E+ Sbjct: 105 VHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISV---MNQLDHANLIQLYDAFES---- 157 Query: 131 RKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPE 190 + +++VME +DGGELF RI D TE + MK I E I+++H + I H D+KPE Sbjct: 158 KNDIVLVMEYVDGGELFDRIIDES-YNLTELDTILFMKQICEGIRHMHQMYILHLDLKPE 216 Query: 191 NLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLG 250 N+L ++ I K+ DFG A+ L TP ++APEV+ + DMWS+G Sbjct: 217 NILCVNRDAKQI-KIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVG 275 Query: 251 VIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEP 310 VI Y+LL G PF ++ I +++ + E+ ++SEE K I LL E Sbjct: 276 VIAYMLLSGLSPFLGDN----DAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEK 331 Query: 311 TQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMT 357 + R++ +E + HPW+ LH+ ++ K R D ++ +T Sbjct: 332 SWRISASEALKHPWL------SDHKLHSRLSAQKKKNRGSDAQDFVT 372 >5YKS-A nrPDB Length = 377 Score = 139 bits (350), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 85/239 (35%), Positives = 134/239 (56%), Gaps = 20/239 (8%) Query: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 Q P+IVR+ +V + + L +++E DGG++F I + ++ E A + I Sbjct: 92 QHPNIVRLYEVIDT----QTKLYLILELGDGGDMFDYIM-KHEEGLNEDLAKKYFAQIVH 146 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAP 232 AI Y H +++ HRD+KPEN+++ K+ ++KLTDFGF+ + LTT C + Y AP Sbjct: 147 AISYCHKLHVVHRDLKPENVVFFEKQ--GLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAP 204 Query: 233 EVLGPEKYDK-SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW 291 E+L ++YD + D+WSLGVI+++L+CG PPF A T I +Y P Sbjct: 205 EILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQE----ANDSETLTMIMDCKYTVP---- 256 Query: 292 SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQT----PLHTSRVLKEDK 346 S VS+E K LI +L+ +P +R ++ E NHPW+ P T PL + + L E++ Sbjct: 257 SHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYKNLSEEE 315 >2A27-A nrPDB Length = 321 Score = 139 bits (349), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 96/286 (33%), Positives = 143/286 (50%), Gaps = 21/286 (7%) Query: 51 GLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ--DCPKARREV--- 105 G++ K ++D+ + LG G V + K T ++A K ++ +RR V Sbjct: 1 GMEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSRE 60 Query: 106 ELHWRAS---QCPH--IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTE 160 E+ S Q H ++ + DVYEN R +++++E + GGELF + + ++ +E Sbjct: 61 EIEREVSILRQVLHHNVITLHDVYEN----RTDVVLILELVSGGELFDFLAQK--ESLSE 114 Query: 161 REASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKR-PNAILKLTDFGFAKETTSHNS 219 EA+ +K I + + YLH+ IAH D+KPEN++ K P +KL DFG A E Sbjct: 115 EEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE 174 Query: 220 LTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRI 279 TP +VAPE++ E DMWS+GVI YILL G PF + I Sbjct: 175 FKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGD----TKQETLANI 230 Query: 280 RMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 Y+F +S+ SE K IR LL E +R+TI E + HPWI Sbjct: 231 TAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWI 276 >1ZWS-A nrPDB Length = 288 Score = 139 bits (349), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 96/286 (33%), Positives = 142/286 (49%), Gaps = 21/286 (7%) Query: 51 GLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ--DCPKARREV--- 105 G++ K ++D+ + LG G V + K T ++A K ++ +RR V Sbjct: 1 GMEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSRE 60 Query: 106 ELHWRAS---QCPH--IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTE 160 E+ S Q H ++ + DVYEN R +++++E + GGELF + + ++ +E Sbjct: 61 EIEREVSILRQVLHHNVITLHDVYEN----RTDVVLILELVSGGELFDFLAQK--ESLSE 114 Query: 161 REASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKR-PNAILKLTDFGFAKETTSHNS 219 EA+ +K I + + YLH+ IAH D+KPEN++ K P +KL DFG A E Sbjct: 115 EEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE 174 Query: 220 LTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRI 279 TP +VAPE++ E DMWS+GVI YILL G PF + I Sbjct: 175 FKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGD----TKQETLANI 230 Query: 280 RMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 Y+F +S SE K IR LL E +R+TI E + HPWI Sbjct: 231 TSVSYDFDEEFFSHTSELAKDFIRKLLVKETRKRLTIQEALRHPWI 276 >1KOB-A nrPDB Length = 387 Score = 137 bits (345), Expect = 9e-33, Method: Compositional matrix adjust. Identities = 86/310 (27%), Positives = 158/310 (50%), Gaps = 24/310 (7%) Query: 52 LQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-----DCPKARREVE 106 +++K+ ++ D Y + + LG G G V + K T F K + D + E+ Sbjct: 42 VEVKQGSVYDYYDILEE-LGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVKNEIS 100 Query: 107 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 + + P ++ + D +E+ Y +++++E L GGELF RI D +E E Sbjct: 101 IMNQLHH-PKLINLHDAFEDKYE----MVLILEFLSGGELFDRIAAE-DYKMSEAEVINY 154 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 226 M+ E ++++H +I H D+KPEN++ +K+ +++ K+ DFG A + + T Sbjct: 155 MRQACEGLKHMHEHSIVHLDIKPENIMCETKKASSV-KIIDFGLATKLNPDEIVKVTTAT 213 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286 + APE++ E DMW++GV+ Y+LL G PF L +K +EF Sbjct: 214 AEFAAPEIVDREPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKR----CDWEF 269 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ-----STKVPQTPLHTSRV 341 +S VS E K I+NLL+ EP +R+T+ + + HPW+ ++++P + +++ Sbjct: 270 DEDAFSSVSPEAKDFIKNLLQKEPRKRLTVHDALEHPWLKGDHSNLTSRIPSS--RYNKI 327 Query: 342 LKEDKERWED 351 ++ KE++ D Sbjct: 328 RQKIKEKYAD 337 >4WB7-A nrPDB Length = 405 Score = 135 bits (339), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 87/270 (32%), Positives = 142/270 (52%), Gaps = 31/270 (11%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELH-------WRASQCPHIVRI 120 + LG G G+V+ + +K T +A+K+L + + H +A P +V++ Sbjct: 102 KTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 161 Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 E + L +VME + GGE+FS ++ G F+E A I +YLHS+ Sbjct: 162 ----EFSFKDNSNLYMVMEYVPGGEMFSHLRRIG--RFSEPHARFYAAQIVLTFEYLHSL 215 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY 240 ++ +RD+KPENLL + +++TDFGFAK T C TP Y+APE++ + Y Sbjct: 216 DLIYRDLKPENLLIDQQ---GYIQVTDFGFAKRVKGRT--WTLCGTPEYLAPEIILSKGY 270 Query: 241 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 300 +K+ D W+LGV++Y + GYPPF+++ + I +I G+ FP S S ++K Sbjct: 271 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYE----KIVSGKVRFP----SHFSSDLKD 322 Query: 301 LIRNLLKTEPTQRM-----TITEFMNHPWI 325 L+RNLL+ + T+R + + NH W Sbjct: 323 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 352 >5X3F-B nrPDB Length = 393 Score = 135 bits (339), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 89/270 (32%), Positives = 146/270 (54%), Gaps = 31/270 (11%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARR-EVELH----WRASQCPHIVRI 120 + LG G G+V+ + +K + +A+K+L Q K ++ E L+ +A P +V++ Sbjct: 90 KTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 149 Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 E + L +VME + GGE+FS ++ G F+E A I +YLHS+ Sbjct: 150 ----EFSFKDNSNLYMVMEYVAGGEMFSHLRRIG--RFSEPHARFYAAQIVLTFEYLHSL 203 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY 240 ++ +RD+KPENLL + +++TDFGFAK T C TP Y+APE++ + Y Sbjct: 204 DLIYRDLKPENLLIDQQ---GYIQVTDFGFAKRVKGRT--WTLCGTPEYLAPEIILSKGY 258 Query: 241 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 300 +K+ D W+LGV++Y + GYPPF+++ + I +I G+ FP S S ++K Sbjct: 259 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYE----KIVSGKVRFP----SHFSSDLKD 310 Query: 301 LIRNLLKTEPTQRM-----TITEFMNHPWI 325 L+RNLL+ + T+R + + NH W Sbjct: 311 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 340 >3UDB-A nrPDB Length = 317 Score = 133 bits (334), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 89/275 (32%), Positives = 145/275 (52%), Gaps = 20/275 (7%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK----ARREVELHWRASQCPH 116 D Y++ + G G G + +K+ E A+K ++ K +RE+ ++ R+ + P+ Sbjct: 19 DRYELVKDI-GAGNFGVARLMRDKQANELVAVKYIERGEKIDENVKREI-INHRSLRHPN 76 Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 IVR ++ + L IVME GGELF RI + G F+E EA + + + Y Sbjct: 77 IVR----FKEVILTPTHLAIVMEYASGGELFERICNAG--RFSEDEARFFFQQLISGVSY 130 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 236 H++ +AHRD+K EN L P LK+ DFG++K + H+ + TP Y+APEVL Sbjct: 131 AHAMQVAHRDLKLENTLLDGS-PAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLL 189 Query: 237 PEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPG--MKTRIRMGQYEFPNPEWSE 293 ++YD K D+WS GV +Y++L G PF P KT R+ ++ P++ Sbjct: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPE----EPKNFRKTIHRILNVQYAIPDYVH 245 Query: 294 VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328 +S E + LI + +P +R++I E NH W +++ Sbjct: 246 ISPECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 >4CFF-A nrPDB Length = 571 Score = 133 bits (334), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 99/313 (31%), Positives = 151/313 (48%), Gaps = 35/313 (11%) Query: 65 VTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD--------CPKARREVELHWRASQCPH 116 V LG+G GKV ++ T K A+K+L K +RE++ + + + PH Sbjct: 36 VLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQ-NLKLFRHPH 94 Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 I+++ V +VME + GGELF I G E EA + + I A+ Y Sbjct: 95 IIKLYQVIST----PTDFFMVMEYVSGGELFDYICKHG--RVEEMEARRLFQQILSAVDY 148 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 236 H + HRD+KPEN+L + NA K+ DFG + + L T C +P Y APEV+ Sbjct: 149 CHRHMVVHRDLKPENVLLDAHM-NA--KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 205 Query: 237 PEKYDK-SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 295 Y D+WS GVI+Y LLCG PF H P + +IR G + P ++ Sbjct: 206 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEH----VPTLFKKIRGGVFYIPE----YLN 257 Query: 296 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ---STKVPQTPLHTSRVL-----KEDKE 347 V L+ ++L+ +P +R TI + H W Q S P+ P + + V+ KE E Sbjct: 258 RSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCE 317 Query: 348 RWEDVKEEMTSAL 360 ++E + E+ ++L Sbjct: 318 KFECTESEVMNSL 330 >4CQG-A nrPDB Length = 331 Score = 132 bits (332), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 90/285 (31%), Positives = 151/285 (52%), Gaps = 36/285 (12%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQ------DCPKARREVELHWRASQCPHIVRIV 121 + +G G KV + T E A+K++ D P+ + E++ ++ + HI ++ Sbjct: 15 ETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDA-LKSLRHQHICQLY 73 Query: 122 DVYENLYAGRKCLLIVMECLDGGELFSRI--QDRGDQAFTEREASEIMKSIGEAIQYLHS 179 V E + + +V+E GGELF I QDR +E E + + I A+ Y+HS Sbjct: 74 HVLET----KNKIFMVLEYCPGGELFDYIISQDR----LSEEETRVVFRQILSAVAYVHS 125 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--LTTPCYTPYYVAPEVLGP 237 AHRD+KPENLL+ N LKL DFG + + L C + Y APE++ Sbjct: 126 QGYAHRDLKPENLLFDE---NHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQG 182 Query: 238 EKYDKS-CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSE 296 + Y S D+WS+G+++Y+L+CG+ PF ++ +A+ +I G+YE P+W +S Sbjct: 183 KSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYK----KIMRGKYEV--PKW--LSP 234 Query: 297 EVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVP-----QTPL 336 +L++ +L+ +P +R+++ +NHPW+MQ P +TPL Sbjct: 235 SSILLLQQMLQVDPKKRISMRNLLNHPWVMQDYSCPVEWQSKTPL 279 >5EZV-A nrPDB Length = 560 Score = 132 bits (332), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 99/313 (31%), Positives = 151/313 (48%), Gaps = 35/313 (11%) Query: 65 VTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD--------CPKARREVELHWRASQCPH 116 V LG+G GKV ++ T K A+K+L K +RE++ + + + PH Sbjct: 31 VLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQ-NLKLFRHPH 89 Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 I+++ V +VME + GGELF I G E EA + + I A+ Y Sbjct: 90 IIKLYQVIST----PTDFFMVMEYVSGGELFDYICKHG--RVEEMEARRLFQQILSAVDY 143 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 236 H + HRD+KPEN+L + NA K+ DFG + + L T C +P Y APEV+ Sbjct: 144 CHRHMVVHRDLKPENVLLDAHM-NA--KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 200 Query: 237 PEKYDK-SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 295 Y D+WS GVI+Y LLCG PF H P + +IR G + P ++ Sbjct: 201 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEH----VPTLFKKIRGGVFYIPE----YLN 252 Query: 296 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ---STKVPQTPLHTSRVL-----KEDKE 347 V L+ ++L+ +P +R TI + H W Q S P+ P + + V+ KE E Sbjct: 253 RSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCE 312 Query: 348 RWEDVKEEMTSAL 360 ++E + E+ ++L Sbjct: 313 KFECTESEVMNSL 325 >5N23-A nrPDB Length = 352 Score = 132 bits (332), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 89/270 (32%), Positives = 144/270 (53%), Gaps = 30/270 (11%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARR-EVELHWR----ASQCPHIVRI 120 + LG G G+V+ + +K T +A+K+L Q K ++ E L+ + A P +V++ Sbjct: 48 RTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNFPFLVKL 107 Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 E + L +V+E GGE+FS ++ G F+E A I +YLHS+ Sbjct: 108 ----EFSFKDNSNLYMVLEYAPGGEMFSHLRRIG--RFSEPHARFYAAQIVLTFEYLHSL 161 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY 240 ++ +RD+KPENLL + +K+ DFGFAK T C TP Y+APE++ + Y Sbjct: 162 DLIYRDLKPENLLIDQQ---GYIKVADFGFAKRVKGRTPWTL-CGTPEYLAPEIILSKGY 217 Query: 241 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 300 +K+ D W+LGV++Y + GYPPF+++ + I +I G+ FP S S ++K Sbjct: 218 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYE----KIVSGKVRFP----SHFSSDLKD 269 Query: 301 LIRNLLKTEPTQRM-----TITEFMNHPWI 325 L+RNLL+ + T+R + + NH W Sbjct: 270 LLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 299 >4D28-A nrPDB Length = 446 Score = 131 bits (330), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 100/280 (35%), Positives = 140/280 (50%), Gaps = 21/280 (7%) Query: 55 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR-REVELHWRASQ 113 KK + Y+V + +G G KV N T + A+K++ + R V+ R Sbjct: 3 KKMRRVGKYEV-GRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 Query: 114 CPHIVR---IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 IVR IV +YE L A + + IV+E + GGELF RI +G E E+ + + + Sbjct: 62 IMKIVRHPNIVRLYEVL-ASKSKIYIVLEFVTGGELFDRIVHKG--RLKEDESRKYFQQL 118 Query: 171 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGF-AKETTSHNSLTTPCYTPYY 229 +A+ + HS + HRD+KPENLL + N LK++DFG A L C TP Y Sbjct: 119 VDAVAHCHSKGVYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLNDTCGTPNY 175 Query: 230 VAPEVLGPEKYDKS-CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN 288 VAPEVL + YD S D+WS GVI++++L GY PF PG+ +I EF Sbjct: 176 VAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD----LPGLYRKINAA--EFDC 229 Query: 289 PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328 P W S EVK LI +L P R+ I PW ++ Sbjct: 230 PPW--FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRKN 267 >4CZT-A nrPDB Length = 464 Score = 130 bits (327), Expect = 9e-31, Method: Compositional matrix adjust. Identities = 85/279 (30%), Positives = 139/279 (49%), Gaps = 30/279 (10%) Query: 67 SQVLGLGINGKVLQIFNKRTQEKFALKMLQD--------CPKARREVELHWRASQCPHIV 118 + LG G KV N + A+K++ + +RE+ + + P+++ Sbjct: 16 GRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREIST-MKLIKHPNVI 74 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 R+ +V A + + V+E + GGELF +I G E EA + + + A+ Y H Sbjct: 75 RMFEVM----ASKTKIYFVLEFVTGGELFDKISSNG--RLKEDEARKYFQQLINAVDYCH 128 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFA---KETTSHNSLTTPCYTPYYVAPEVL 235 S + HRD+KPENLL + N LK++DFG + ++ L T C TP YVAPEV+ Sbjct: 129 SRGVYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVI 185 Query: 236 GPEKYDKS-CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 294 + YD + D+WS GVI+++L+ GY PF ++ ++ ++ + EF P W Sbjct: 186 NNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYK------KIFKAEFTCPPW--F 237 Query: 295 SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ 333 S K LI+ +L P R+T E + + W + K P+ Sbjct: 238 SASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPK 276 >4CFH-A nrPDB Length = 493 Score = 130 bits (326), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 99/313 (31%), Positives = 156/313 (49%), Gaps = 35/313 (11%) Query: 65 VTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD--------CPKARREVELHWRASQCPH 116 + LG+G GKV ++ T K A+K+L K RRE++ + + + PH Sbjct: 36 ILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQ-NLKLFRHPH 94 Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 I+++ V + + +VME + GGELF I G E+E+ + + I + Y Sbjct: 95 IIKLYQVI----STPSDIFMVMEYVSGGELFDYICKNG--RLDEKESRRLFQQILSGVDY 148 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 236 H + HRD+KPEN+L + NA K+ DFG + + L T C +P Y APEV+ Sbjct: 149 CHRHMVVHRDLKPENVLLDAHM-NA--KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 205 Query: 237 PEKYDK-SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 295 Y D+WS GVI+Y LLCG PF +H P + +I G F P++ ++ Sbjct: 206 GRLYAGPEVDIWSSGVILYALLCGTLPFDDDH----VPTLFKKICDGI--FYTPQY--LN 257 Query: 296 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQST---KVPQTPLHTSRV-----LKEDKE 347 V L++++L+ +P +R TI + H W Q P+ P ++S + LKE E Sbjct: 258 PSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCE 317 Query: 348 RWEDVKEEMTSAL 360 ++E +EE+ S L Sbjct: 318 KFECSEEEVLSCL 330 >4YNZ-A nrPDB Length = 342 Score = 129 bits (325), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 84/274 (30%), Positives = 144/274 (52%), Gaps = 26/274 (9%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQD-------CPKARREVELHWRASQCPHIVRI 120 + LG G G V + T +K A+K++ K RE+ + + + PH++++ Sbjct: 16 KTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAI-LKLIEHPHVLKL 74 Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 DVYEN +K L +V+E + GGELF + +G T +EA + + I A+ + HS Sbjct: 75 HDVYEN----KKYLYLVLEHVSGGELFDYLVKKG--RLTPKEARKFFRQIISALDFCHSH 128 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY 240 +I HRD+KPENLL +R N +++ DFG A + L T C +P+Y PEV+ EKY Sbjct: 129 SICHRDLKPENLL-LDERNN--IRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKY 185 Query: 241 D-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVK 299 D + D+WS GVI++ LL G PF ++ + +++ G + P+ + + + Sbjct: 186 DGRKADVWSCGVILFALLVGALPFDDDN----LRQLLEKVKRGVFHMPHF----IPPDCQ 237 Query: 300 MLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ 333 L+R +++ + +R+T+ H W + P+ Sbjct: 238 SLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPE 271 >3LM0-A nrPDB Length = 327 Score = 129 bits (325), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 83/274 (30%), Positives = 138/274 (50%), Gaps = 19/274 (6%) Query: 63 YKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------QDC-PKARREVELHWRASQCP 115 Y +TS+ LG G V Q +K T +++A K L QDC + E+ + A CP Sbjct: 30 YILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCP 89 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 ++ + +VYEN +++++E GGE+FS + +E + ++K I E + Sbjct: 90 RVINLHEVYENTSE----IILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVY 145 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL 235 YLH NI H D+KP+N+L +S P +K+ DFG +++ L TP Y+APE+L Sbjct: 146 YLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEIL 205 Query: 236 GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQ--YEFPNPEWSE 293 + + DMW++G+I Y+LL PF +T + + Q ++ +S Sbjct: 206 NYDPITTATDMWNIGIIAYMLLTHTSPFVG------EDNQETYLNISQVNVDYSEETFSS 259 Query: 294 VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 VS+ I++LL P +R T ++H W+ Q Sbjct: 260 VSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQ 293 >4REW-A nrPDB Length = 540 Score = 129 bits (324), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 98/313 (31%), Positives = 155/313 (49%), Gaps = 35/313 (11%) Query: 65 VTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD--------CPKARREVELHWRASQCPH 116 + LG+G GKV ++ T K A+K+L K RRE++ + + + PH Sbjct: 9 ILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQ-NLKLFRHPH 67 Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 I+++ V + + +VME + GGELF I G E+E+ + + I + Y Sbjct: 68 IIKLYQVI----STPSDIFMVMEYVSGGELFDYICKNG--RLDEKESRRLFQQILSGVDY 121 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 236 H + HRD+KPEN+L + NA K+ DFG + + L T C +P Y APEV+ Sbjct: 122 CHRHMVVHRDLKPENVLLDAHM-NA--KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 178 Query: 237 PEKYDK-SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 295 Y D+WS GVI+Y LLCG PF +H P + +I G F P++ ++ Sbjct: 179 GRLYAGPEVDIWSSGVILYALLCGTLPFDDDH----VPTLFKKICDGI--FYTPQY--LN 230 Query: 296 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQST---KVPQTPLHTS-----RVLKEDKE 347 V L++++L+ +P +R +I + H W Q P+ P ++S LKE E Sbjct: 231 PSVISLLKHMLQVDPMKRASIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCE 290 Query: 348 RWEDVKEEMTSAL 360 ++E +EE+ S L Sbjct: 291 KFECSEEEVLSCL 303 >5WAX-A nrPDB Length = 310 Score = 129 bits (323), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 90/273 (32%), Positives = 139/273 (50%), Gaps = 16/273 (5%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE---LHWRASQCPHI 117 D Y++ + G G G + N+ + A+K ++ K V+ ++ R+ + P+I Sbjct: 11 DRYELVRDI-GSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQREIINHRSLRHPNI 69 Query: 118 VRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL 177 +R ++ + L IVME GGELF RI + G F+E EA + + + Y Sbjct: 70 IR----FKEVILTPTHLAIVMEYASGGELFERICNAG--RFSEDEARFFFQQLISGVSYC 123 Query: 178 HSINIAHRDVKPEN-LLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 236 HS+ + HRD+K EN LL S P LK+ DFG++K + H+ + TP Y+APEVL Sbjct: 124 HSMQVCHRDLKLENTLLDGSTAPR--LKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 181 Query: 237 PEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 295 ++YD K D+WS GV +Y++L G PF RI QY P+ + +S Sbjct: 182 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPD--YVHIS 239 Query: 296 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328 E + LI + P R+TI E NHPW +++ Sbjct: 240 PECQDLISRIFVANPATRITIPEIRNHPWFLKN 272 >4D2V-A nrPDB Length = 356 Score = 129 bits (323), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 89/281 (31%), Positives = 144/281 (51%), Gaps = 31/281 (11%) Query: 63 YKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ------DCPKARREVELHWRASQCPH 116 Y + +G G KV + T E A+K++ D P+ + E+E + + H Sbjct: 30 YYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEA-LKNLRHQH 88 Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRI--QDRGDQAFTEREASEIMKSIGEAI 174 I ++ V E A + + +V+E GGELF I QDR +E E + + I A+ Sbjct: 89 ICQLYHVLET--ANK--IFMVLEYCPGGELFDYIISQDR----LSEEETRVVFRQIVSAV 140 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--LTTPCYTPYYVAP 232 Y+HS AHRD+KPENLL+ LKL DFG + + L C Y AP Sbjct: 141 AYVHSQGYAHRDLKPENLLFDEYHK---LKLIDFGLCAKPKGNKDYHLQACCGALAYAAP 197 Query: 233 EVLGPEKYDKS-CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW 291 E++ + Y S D+WS+G+++Y+L+CG+ PF + A+ +I G+Y+ P+W Sbjct: 198 ELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALV----AKIMRGKYDV--PKW 251 Query: 292 SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVP 332 +S +L++ +L+ +P +R+++ +NHPWIMQ P Sbjct: 252 --LSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYP 290 >3HDN-A nrPDB Length = 373 Score = 128 bits (322), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 84/253 (33%), Positives = 134/253 (52%), Gaps = 20/253 (7%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI-----VD 122 +V+G G GKVL +K + +A+K+LQ +++ E H + + + + V Sbjct: 44 KVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVG 103 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182 ++ + K L V++ ++GGELF +Q ++ F E A I A+ YLHS+NI Sbjct: 104 LHFSFQTADK-LYFVLDYINGGELFYHLQR--ERCFLEPRARFYAAEIASALGYLHSLNI 160 Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TPCYTPYYVAPEVLGPEKYD 241 +RD+KPEN+L S+ + LTDFG KE HNS T T C TP Y+APEVL + YD Sbjct: 161 VYRDLKPENILLDSQ---GHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYD 217 Query: 242 KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKML 301 ++ D W LG ++Y +L G PPFYS + + + + P ++ + L Sbjct: 218 RTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNK--------PLQLKPNITNSARHL 269 Query: 302 IRNLLKTEPTQRM 314 + LL+ + T+R+ Sbjct: 270 LEGLLQKDRTKRL 282 >3ZUT-A nrPDB Length = 362 Score = 127 bits (319), Expect = 9e-30, Method: Compositional matrix adjust. Identities = 87/273 (31%), Positives = 142/273 (52%), Gaps = 16/273 (5%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK----ARREVELHWRASQCPH 116 D Y++ + G G G + +K++ E A+K ++ K +RE+ H R+ + P+ Sbjct: 19 DRYELVKDI-GSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINH-RSLRHPN 76 Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 IVR ++ + L IVME GGELF RI + G F+E EA + + + Y Sbjct: 77 IVR----FKEVILTPTHLAIVMEYASGGELFERICNAG--RFSEDEARFFFQQLISGVSY 130 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 236 H++ + HRD+K EN L P LK+ FG++K + H+ + TP Y+APEVL Sbjct: 131 CHAMQVCHRDLKLENTLLDGS-PAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 189 Query: 237 PEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 295 ++YD K D+WS GV +Y++L G PF KT R+ ++ P++ +S Sbjct: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPE--EPKNFRKTIHRILNVQYAIPDYVHIS 247 Query: 296 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328 E + LI + +P +R++I E NH W +++ Sbjct: 248 PECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 >3IS5-A nrPDB Length = 285 Score = 126 bits (317), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 85/279 (30%), Positives = 144/279 (51%), Gaps = 23/279 (8%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ----DCPKARREVELH-WRASQC 114 IDD + + LG G G V + + + + +K + P + E E+ ++ Sbjct: 20 IDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLKSLDH 79 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRI---QDRGDQAFTEREASEIMKSIG 171 P+I++I +V+E+ + + IVME +GGEL RI Q RG +A +E +E+MK + Sbjct: 80 PNIIKIFEVFEDYHN----MYIVMETCEGGELLERIVSAQARG-KALSEGYVAELMKQMM 134 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVA 231 A+ Y HS ++ H+D+KPEN+L+ P++ +K+ DFG A+ S T T Y+A Sbjct: 135 NALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMA 194 Query: 232 PEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN--P 289 PEV + K CD+WS GV+MY LL G PF ++ + Y+ PN Sbjct: 195 PEVFKRDVTFK-CDIWSAGVVMYFLLTGCLPF-------TGTSLEEVQQKATYKEPNYAV 246 Query: 290 EWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328 E ++ + L++ +L +P +R + + ++H W Q+ Sbjct: 247 ECRPLTPQAVDLLKQMLTKDPERRPSAAQVLHHEWFKQA 285 >4RED-A nrPDB Length = 351 Score = 125 bits (315), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 96/313 (30%), Positives = 154/313 (49%), Gaps = 35/313 (11%) Query: 65 VTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD--------CPKARREVELHWRASQCPH 116 + LG+G GKV ++ T A+K+L K RRE++ + + + PH Sbjct: 17 ILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQ-NLKLFRHPH 75 Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 I+++ V + +VME + GGELF I G E+E+ + + I + Y Sbjct: 76 IIKLYQVIST----PSDIFMVMEYVSGGELFDYICKNG--RLDEKESRRLFQQILSGVDY 129 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 236 H + HRD+KPEN+L + NA K+ DFG + + L T C +P Y APEV+ Sbjct: 130 CHRHMVVHRDLKPENVLLDAHM-NA--KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 Query: 237 PEKYDK-SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 295 Y D+WS GVI+Y LLCG PF +H P + +I G F P++ ++ Sbjct: 187 GRLYAGPEVDIWSSGVILYALLCGTLPFDDDH----VPTLFKKICDGI--FYTPQY--LN 238 Query: 296 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQST---KVPQTPLHTSRV-----LKEDKE 347 V L++++L+ +P +R +I + H W Q P+ P +++ + LKE E Sbjct: 239 PSVISLLKHMLQVDPMKRASIKDIREHEWFKQDLPKYLFPEDPSYSTTMIDDEALKEVCE 298 Query: 348 RWEDVKEEMTSAL 360 ++E +EE+ S L Sbjct: 299 KFECSEEEVLSCL 311 >1FOT-A nrPDB Length = 318 Score = 125 bits (315), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 90/278 (32%), Positives = 146/278 (52%), Gaps = 32/278 (11%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR-REVE------LHWRAS 112 + D+++ + LG G G+V I ++ +A+K+L+ R ++VE L Sbjct: 5 LQDFQIL-RTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIV 63 Query: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 P I+R+ +++ + + ++M+ ++GGELFS + R Q F A + Sbjct: 64 THPFIIRMWGTFQD----AQQIFMIMDYIEGGELFSLL--RKSQRFPNPVAKFYAAEVCL 117 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAP 232 A++YLHS +I +RD+KPEN+L N +K+TDFGFAK + T C TP Y+AP Sbjct: 118 ALEYLHSKDIIYRDLKPENILLDK---NGHIKITDFGFAKYVP--DVTYTLCGTPDYIAP 172 Query: 233 EVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWS 292 EV+ + Y+KS D WS G+++Y +L GY PFY S MKT ++ E P + Sbjct: 173 EVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYD------SNTMKTYEKILNAELRFPPF- 225 Query: 293 EVSEEVKMLIRNLLKTEPTQRM-----TITEFMNHPWI 325 +E+VK L+ L+ + +QR+ + NHPW Sbjct: 226 -FNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWF 262 >2JDO-A nrPDB Length = 342 Score = 125 bits (315), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 89/268 (33%), Positives = 134/268 (50%), Gaps = 22/268 (8%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKML-QDCPKARREVELHWRASQCPHIVR--IVDVY 124 ++LG G GKV+ + K T +A+K+L ++ A+ EV S+ R + Sbjct: 16 KLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTAL 75 Query: 125 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 184 + + L VME +GGELF + ++ FTE A I A++YLHS ++ + Sbjct: 76 KYAFQTHDRLCFVMEYANGGELFFHLSR--ERVFTEERARFYGAEIVSALEYLHSRDVVY 133 Query: 185 RDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN-SLTTPCYTPYYVAPEVLGPEKYDKS 243 RD+K ENL+ + +K+TDFG KE S ++ T C TP Y+APEVL Y ++ Sbjct: 134 RDIKLENLMLDK---DGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRA 190 Query: 244 CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIR 303 D W LGV+MY ++CG PFY+ + I M + FP +S E K L+ Sbjct: 191 VDWWGLGVVMYEMMCGRLPFYNQD----HERLFELILMEEIRFPRT----LSPEAKSLLA 242 Query: 304 NLLKTEPTQRM-----TITEFMNHPWIM 326 LLK +P QR+ E M H + + Sbjct: 243 GLLKKDPKQRLGGGPSDAKEVMEHRFFL 270 >1TKI-A nrPDB Length = 321 Score = 124 bits (311), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 71/232 (30%), Positives = 118/232 (50%), Gaps = 8/232 (3%) Query: 134 LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL 193 L+++ E + G ++F RI + ERE + + EA+Q+LHS NI H D++PEN++ Sbjct: 76 LVMIFEFISGLDIFERINTSAFE-LNEREIVSYVHQVCEALQFLHSHNIGHFDIRPENII 134 Query: 194 YTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIM 253 Y ++R + I K+ +FG A++ ++ P Y APEV + + DMWSLG ++ Sbjct: 135 YQTRRSSTI-KIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDVVSTATDMWSLGTLV 193 Query: 254 YILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQR 313 Y+LL G PF + I I +Y F + E+S E + LL E R Sbjct: 194 YVLLSGINPFLAETNQQIIEN----IMNAEYTFDEEAFKEISIEAMDFVDRLLVKERKSR 249 Query: 314 MTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRV 365 MT +E + HPW+ Q K+ + R LK + +K+++ ++ R+ Sbjct: 250 MTASEALQHPWLKQ--KIERVSTKVIRTLKHRRYYHTLIKKDLNMVVSAARI 299 >5ES1-A nrPDB Length = 328 Score = 124 bits (311), Expect = 7e-29, Method: Compositional matrix adjust. Identities = 81/227 (35%), Positives = 118/227 (51%), Gaps = 19/227 (8%) Query: 100 KARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFT 159 K REV + + P+IV++ +V E K L +VME GE+F + G Sbjct: 60 KLFREVRI-MKGLNHPNIVKLFEVIET----EKTLYLVMEYASAGEVFDYLVSHG--RMK 112 Query: 160 EREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS 219 E+EA + I A+ Y H NI HRD+K ENLL ++ A +K+ DFGF+ E T + Sbjct: 113 EKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAE---ANIKIADFGFSNEFTLGSK 169 Query: 220 LTTPCYTPYYVAPEVLGPEKYDK-SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTR 278 L T C +P Y APE+ +KYD D+WSLGVI+Y L+ G PF H L ++ R Sbjct: 170 LDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPF-DGHNL---KELRER 225 Query: 279 IRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 + G+Y P +S + + ++R L P +R T+ + M WI Sbjct: 226 VLRGKYRVP----FYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWI 268 >2YZA-A nrPDB Length = 276 Score = 124 bits (310), Expect = 9e-29, Method: Compositional matrix adjust. Identities = 88/273 (32%), Positives = 130/273 (47%), Gaps = 27/273 (9%) Query: 65 VTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD--------CPKARREVELHWRASQCPH 116 V LG+G GKV ++ T K A+K+L K +RE++ + + + PH Sbjct: 14 VLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQ-NLKLFRHPH 72 Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 I+++ V +VME + GGELF I G E EA + + I A+ Y Sbjct: 73 IIKLYQVIST----PTDFFMVMEYVSGGELFDYICKHG--RVEEMEARRLFQQILSAVDY 126 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 236 H + HRD+KPEN+L + NA K+ DFG + + L C +P Y APEV+ Sbjct: 127 CHRHMVVHRDLKPENVLLDA-HMNA--KIADFGLSNMMSDGEFLRDSCGSPNYAAPEVIS 183 Query: 237 PEKYDK-SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 295 Y D+WS GVI+Y LLCG PF H P + +IR G + P ++ Sbjct: 184 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEH----VPTLFKKIRGGVFYIP----EYLN 235 Query: 296 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328 V L+ ++L+ +P +R TI + H W Q Sbjct: 236 RSVATLLMHMLQVDPLKRATIKDIREHEWFKQD 268 >6BDL-A nrPDB Length = 347 Score = 122 bits (306), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 90/279 (32%), Positives = 137/279 (49%), Gaps = 23/279 (8%) Query: 57 NAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEK-FALKMLQDCPKARREVELHWRAS--- 112 N + D+ + LG+G G+V + K + K FA+K+L+ + H R+ Sbjct: 30 NLKLSDFNII-DTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQI 88 Query: 113 -QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 Q H IV +Y + K L ++ME GGEL++ ++DRG +F + + Sbjct: 89 MQGAHSDFIVRLYRT-FKDSKYLYMLMEACLGGELWTILRDRG--SFEDSTTRFYTACVV 145 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVA 231 EA YLHS I +RD+KPENL+ + KL DFGFAK+ T C TP YVA Sbjct: 146 EAFAYLHSKGIIYRDLKPENLILDHR---GYAKLVDFGFAKKIGFGKKTWTFCGTPEYVA 202 Query: 232 PEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW 291 PE++ + +D S D WSLG++MY LL G PPF + + I M EFP Sbjct: 203 PEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM--IEFP---- 256 Query: 292 SEVSEEVKMLIRNLLKTEPTQRM-----TITEFMNHPWI 325 ++++ LI+ L + P++R+ + + H W Sbjct: 257 KKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWF 295 >5KZ7-A nrPDB Length = 346 Score = 122 bits (305), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 79/227 (34%), Positives = 118/227 (51%), Gaps = 19/227 (8%) Query: 100 KARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFT 159 K REV + + P+IV++ +V E K L +VME GGE+F + G Sbjct: 78 KLFREVRI-MKVLNHPNIVKLFEVIET----EKTLYLVMEYASGGEVFDYLVAHG--RMK 130 Query: 160 EREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS 219 E+EA + I A+QY H I HRD+K ENLL + + +K+ DFGF+ E T N Sbjct: 131 EKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDA---DMNIKIADFGFSNEFTFGNK 187 Query: 220 LTTPCYTPYYVAPEVLGPEKYDK-SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTR 278 L T C +P Y APE+ +KYD D+WSLGVI+Y L+ G PF + ++ R Sbjct: 188 LDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQN----LKELRER 243 Query: 279 IRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 + G+Y P +S + + L++ L P++R T+ + M W+ Sbjct: 244 VLRGKYRIP----FYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 286 >3D2K-A nrPDB Length = 272 Score = 121 bits (304), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 93/291 (31%), Positives = 150/291 (51%), Gaps = 32/291 (10%) Query: 52 LQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKA------RR 103 L K+ ++D+ + + LG G G V ++++ ALK+L KA RR Sbjct: 3 LGSKRQWTLEDFDI-GRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRR 61 Query: 104 EVEL--HWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTER 161 EVE+ H R P+I+R+ + + A R + +++E G ++ +Q F E+ Sbjct: 62 EVEIQSHLRH---PNILRLYGYFHD--ATR--VYLILEYAPLGTVYRELQKL--SRFDEQ 112 Query: 162 EASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT 221 + + + A+ Y HS + HRD+KPENLL S N LK+ DFG++ S + T Sbjct: 113 RTATYITELANALSYCHSKRVIHRDIKPENLLLGS---NGELKIADFGWSVHAPS-SRRT 168 Query: 222 TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRM 281 T C T Y+ PE++ +D+ D+WSLGV+ Y L G PPF ++ +T R+ Sbjct: 169 TLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAH------TYQETYRRI 222 Query: 282 GQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVP 332 + EF P++ V+E + LI LLK +QR+T+ E + HPWI ++ P Sbjct: 223 SRVEFTFPDF--VTEGARDLISRLLKHNASQRLTLAEVLEHPWIKANSSKP 271 >3H4J-B nrPDB Length = 336 Score = 121 bits (303), Expect = 7e-28, Method: Compositional matrix adjust. Identities = 86/271 (31%), Positives = 133/271 (49%), Gaps = 30/271 (11%) Query: 65 VTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQ---------CP 115 + + LG G GKV + +TQ+K ALK + + ++ ++H R + P Sbjct: 12 IIRETLGEGSFGKVKLATHYKTQQKVALKFIS--RQLLKKSDMHMRVEREISYLKLLRHP 69 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 HI+++ DV +++V+E GGELF I ++ + TE E + I AI+ Sbjct: 70 HIIKLYDVI----TTPTDIVMVIE-YAGGELFDYIVEK--KRMTEDEGRRFFQQIICAIE 122 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL 235 Y H I HRD+KPENLL N +K+ DFG + T N L T C +P Y APEV+ Sbjct: 123 YCHRHKIVHRDLKPENLLLDD---NLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVI 179 Query: 236 GPEKYDK-SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 294 + Y D+WS G+++Y++L G PF P + ++ Y P+ + Sbjct: 180 NGKLYAGPEVDVWSCGIVLYVMLVGRLPFDDE----FIPNLFKKVNSCVYVMPDF----L 231 Query: 295 SEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 S + LIR ++ +P QR+TI E PW Sbjct: 232 SPGAQSLIRRMIVADPMQRITIQEIRRDPWF 262 >6FDY-U nrPDB Length = 276 Score = 120 bits (302), Expect = 9e-28, Method: Compositional matrix adjust. Identities = 86/276 (31%), Positives = 149/276 (53%), Gaps = 29/276 (10%) Query: 62 DYKVTSQVLGLGINGKVLQIFNKR-TQEKFALKML--QDCPKAR-----REVELHWRASQ 113 D + ++ LG G V + + K+ T+E A+K + + KA E+E+ + + Sbjct: 11 DGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEI-LKGIR 69 Query: 114 CPHIVRIVDVY---ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 PHIV++ D +N+Y ++ME GG+L I R + E+ A M+ + Sbjct: 70 HPHIVQLKDFQWDSDNIY-------LIMEFCAGGDLSRFIHTR--RILPEKVARVFMQQL 120 Query: 171 GEAIQYLHSINIAHRDVKPENLLYTS-KRPNAILKLTDFGFAKETTSHNSLTTPCYTPYY 229 A+Q+LH NI+H D+KP+N+L +S ++P+ LKL DFGFA+ + + +P Y Sbjct: 121 ASALQFLHERNISHLDLKPQNILLSSLEKPH--LKLADFGFAQHMSPWDEKHVLRGSPLY 178 Query: 230 VAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNP 289 +APE++ +YD D+WS+GVI+Y L G PPF S ++ +IR + P Sbjct: 179 MAPEMVCQRQYDARVDLWSMGVILYEALFGQPPFASRS----FSELEEKIRSNRV-IELP 233 Query: 290 EWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 +S + + L++ LL+ +P++R++ +F HPW+ Sbjct: 234 LRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWV 269 >4UZD-A nrPDB Length = 287 Score = 120 bits (301), Expect = 9e-28, Method: Compositional matrix adjust. Identities = 91/289 (31%), Positives = 147/289 (50%), Gaps = 32/289 (11%) Query: 54 IKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP--------KARREV 105 +K+ ++D+++ + LG G G V K+++ ALK+L + RREV Sbjct: 1 MKRQWALEDFEI-GRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREV 59 Query: 106 EL--HWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREA 163 E+ H R P+I+R+ + + A R + +++E G ++ +Q F E+ Sbjct: 60 EIQSHLRH---PNILRLYGYFHD--ATR--VYLILEYAPLGTVYRELQKLSK--FDEQRT 110 Query: 164 SEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTP 223 + + + A+ Y HS + HRD+KPENLL S LK+ DFG++ S TT Sbjct: 111 ATYITELANALSYCHSKRVIHRDIKPENLLLGSA---GELKIADFGWSVHAPSSRR-TTL 166 Query: 224 CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQ 283 C T Y+ PE++ +D+ D+WSLGV+ Y L G PPF +N +T R+ + Sbjct: 167 CGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEAN------TYQETYKRISR 220 Query: 284 YEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVP 332 EF P++ V+E + LI LLK P+QR + E + HPWI ++ P Sbjct: 221 VEFTFPDF--VTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKP 267 >2QNJ-A nrPDB Length = 328 Score = 120 bits (301), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 78/227 (34%), Positives = 116/227 (51%), Gaps = 19/227 (8%) Query: 100 KARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFT 159 K REV + + P+IV++ +V E K L ++ME GGE+F + G Sbjct: 57 KLFREVRI-MKILNHPNIVKLFEVIET----EKTLYLIMEYASGGEVFDYLVAHG--RMK 109 Query: 160 EREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS 219 E+EA + I A+QY H I HRD+K ENLL + + +K+ DFGF+ E T Sbjct: 110 EKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDA---DMNIKIADFGFSNEFTVGGK 166 Query: 220 LTTPCYTPYYVAPEVLGPEKYDK-SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTR 278 L T C +P Y APE+ +KYD D+WSLGVI+Y L+ G PF + ++ R Sbjct: 167 LDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQN----LKELRER 222 Query: 279 IRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 + G+Y P +S + + L++ L P +R T+ + M WI Sbjct: 223 VLRGKYRIP----FYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 265 >3HKO-A nrPDB Length = 345 Score = 120 bits (301), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 94/314 (29%), Positives = 141/314 (44%), Gaps = 67/314 (21%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKML----------QDCPKARREVELHWRASQCPHIVR 119 +G G G V +T+ A+K++ +D + + EV L + P+I R Sbjct: 34 IGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKLHH-PNIAR 92 Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQA---------------------- 157 + +VYE+ + + +VME GG L ++ D + Sbjct: 93 LYEVYED----EQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECNEE 148 Query: 158 --------------FTEREA--SEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNA 201 F +RE S IM+ I A+ YLH+ I HRD+KPEN L+++ + Sbjct: 149 AINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKSFE 208 Query: 202 ILKLTDFGFAKETTSHNS-----LTTPCYTPYYVAPEVLGP--EKYDKSCDMWSLGVIMY 254 I KL DFG +KE N+ +TT TPY+VAPEVL E Y CD WS GV+++ Sbjct: 209 I-KLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVLLH 267 Query: 255 ILLCGYPPF-YSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQR 313 +LL G PF N IS + ++ F NP ++ +S + L+ NLL +R Sbjct: 268 LLLMGAVPFPGVNDADTISQVLNKKLC-----FENPNYNVLSPLARDLLSNLLNRNVDER 322 Query: 314 MTITEFMNHPWIMQ 327 + HPWI Q Sbjct: 323 FDAMRALQHPWISQ 336 >3MN3-A nrPDB Length = 271 Score = 120 bits (301), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 90/276 (32%), Positives = 135/276 (48%), Gaps = 29/276 (10%) Query: 58 AIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR--------REVELHW 109 A I +Y++ + LG G GKV ++ T +K ALK++ A+ RE+ + Sbjct: 1 AHIGNYQIV-KTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREIS-YL 58 Query: 110 RASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 169 R + PHI+++ DV ++ + +++V+E G ELF I R +E+EA + Sbjct: 59 RLLRHPHIIKLYDVIKS----KDEIIMVIE-YAGNELFDYIVQR--DKMSEQEARRFFQQ 111 Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYY 229 I A++Y H I HRD+KPENLL +K+ DFG + T N L T C +P Y Sbjct: 112 IISAVEYCHRHKIVHRDLKPENLLLDEHLN---VKIADFGLSNIMTDGNFLKTSCGSPNY 168 Query: 230 VAPEVLGPEKYDK-SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN 288 APEV+ + Y D+WS GVI+Y++LC PF P + I G Y P Sbjct: 169 AAPEVISGKLYAGPEVDVWSCGVILYVMLCRRLPFDDES----IPVLFKNISNGVYTLP- 223 Query: 289 PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPW 324 +S LI+ +L P R++I E M W Sbjct: 224 ---KFLSPGAAGLIKRMLIVNPLNRISIHEIMQDDW 256 >3UC3-A nrPDB Length = 361 Score = 120 bits (300), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 83/263 (31%), Positives = 133/263 (50%), Gaps = 13/263 (4%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE---LHWRASQCPHIVRIVDVYEN 126 +G G G + +K T+E A+K ++ V+ ++ R+ + P+IVR ++ Sbjct: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGAAIDENVQREIINHRSLRHPNIVR----FKE 83 Query: 127 LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRD 186 + L I+ME GGEL+ RI + G F+E EA + + + Y HS+ I HRD Sbjct: 84 VILTPTHLAIIMEYASGGELYERICNAG--RFSEDEARFFFQQLLSGVSYCHSMQICHRD 141 Query: 187 VKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYD-KSCD 245 +K EN L P LK+ DFG++K + H+ + TP Y+APEVL ++YD K D Sbjct: 142 LKLENTLLDGS-PAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIAD 200 Query: 246 MWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNL 305 +WS GV +Y++L G PF KT R+ ++ P+ +S E LI + Sbjct: 201 VWSCGVTLYVMLVGAYPFEDPE--EPRDYRKTIQRILSVKYSIPDDIRISPECCHLISRI 258 Query: 306 LKTEPTQRMTITEFMNHPWIMQS 328 +P R++I E H W +++ Sbjct: 259 FVADPATRISIPEIKTHSWFLKN 281 >4B8L-A nrPDB Length = 286 Score = 117 bits (294), Expect = 6e-27, Method: Compositional matrix adjust. Identities = 88/286 (30%), Positives = 141/286 (49%), Gaps = 32/286 (11%) Query: 55 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP--------KARREVE 106 K+ IDD+ + + LG G G V K+ + ALK+L + RRE+E Sbjct: 9 KRKFTIDDFDI-GRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIE 67 Query: 107 L--HWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREAS 164 + H R P+I+R+ N + RK + +++E GEL+ +Q G F E+ ++ Sbjct: 68 IQSHLRH---PNILRMY----NYFHDRKRIYLMLEFAPRGELYKELQKHG--RFDEQRSA 118 Query: 165 EIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPC 224 M+ + +A+ Y H + HRD+KPENLL K LK+ DFG++ S T C Sbjct: 119 TFMEELADALHYCHERKVIHRDIKPENLLMGYK---GELKIADFGWSVHAPSLRRRTM-C 174 Query: 225 YTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQY 284 T Y+ PE++ + +D+ D+W GV+ Y L G PPF S +T R+ Sbjct: 175 GTLDYLPPEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFDS------PSHTETHRRIVNV 228 Query: 285 EFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTK 330 + P + +S+ K LI LL+ P QR+ + M HPW+ +++ Sbjct: 229 DLKFPPF--LSDGSKDLISKLLRYHPPQRLPLKGVMEHPWVKANSR 272 >5KCV-A nrPDB Length = 460 Score = 115 bits (288), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 83/252 (32%), Positives = 126/252 (50%), Gaps = 18/252 (7%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQ-DCPKARREVELHWRASQCPHIVR--IVDVY 124 ++LG G GKV+ + K T +A+K+L+ + A+ EV ++ R + Sbjct: 168 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTAL 227 Query: 125 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS-INIA 183 + + L VME +GGELF + ++ F+E A I A+ YLHS N+ Sbjct: 228 KYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALDYLHSEKNVV 285 Query: 184 HRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN-SLTTPCYTPYYVAPEVLGPEKYDK 242 +RD+K ENL+ + +K+TDFG KE ++ T C TP Y+APEVL Y + Sbjct: 286 YRDLKLENLMLDK---DGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGR 342 Query: 243 SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI 302 + D W LGV+MY ++CG PFY+ + I M + FP + E K L+ Sbjct: 343 AVDWWGLGVVMYEMMCGRLPFYNQD----HEKLFELILMEEIRFPRT----LGPEAKSLL 394 Query: 303 RNLLKTEPTQRM 314 LLK +P QR+ Sbjct: 395 SGLLKKDPKQRL 406 >3MV5-A nrPDB Length = 342 Score = 115 bits (287), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 83/252 (32%), Positives = 126/252 (50%), Gaps = 18/252 (7%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQ-DCPKARREVELHWRASQCPHIVR--IVDVY 124 ++LG G GKV+ + K T +A+K+L+ + A+ EV ++ R + Sbjct: 16 KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTAL 75 Query: 125 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS-INIA 183 + + L VME +GGELF + ++ F+E A I A+ YLHS N+ Sbjct: 76 KYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALDYLHSEKNVV 133 Query: 184 HRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN-SLTTPCYTPYYVAPEVLGPEKYDK 242 +RD+K ENL+ + +K+TDFG KE ++ T C TP Y+APEVL Y + Sbjct: 134 YRDLKLENLMLDK---DGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGR 190 Query: 243 SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI 302 + D W LGV+MY ++CG PFY+ + I M + FP + E K L+ Sbjct: 191 AVDWWGLGVVMYEMMCGRLPFYNQD----HEKLFELILMEEIRFPRT----LGPEAKSLL 242 Query: 303 RNLLKTEPTQRM 314 LLK +P QR+ Sbjct: 243 SGLLKKDPKQRL 254 >4JXF-A nrPDB Length = 266 Score = 115 bits (287), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 82/279 (29%), Positives = 138/279 (49%), Gaps = 27/279 (9%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD--------CPKARREVELHWRA 111 I+D+KV +LG G V + + T + A+KM+ + + EV++H + Sbjct: 6 IEDFKV-GNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQL 64 Query: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 P I+ + + +E+ + +V+E GE+ +++R + F+E EA M I Sbjct: 65 KH-PSILELYNYFED----SNYVYLVLEMCHNGEMNRYLKNRV-KPFSENEARHFMHQII 118 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS-HNSLTTPCYTPYYV 230 + YLHS I HRD+ NLL T N +K+ DFG A + H T C TP Y+ Sbjct: 119 TGMLYLHSHGILHRDLTLSNLLLTR---NMNIKIADFGLATQLKMPHEKHYTLCGTPNYI 175 Query: 231 APEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE 290 +PE+ + D+WSLG + Y LL G PPF ++ ++ + YE P Sbjct: 176 SPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTD----TVKNTLNKVVLADYEMP--- 228 Query: 291 WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQST 329 S +S E K LI LL+ P R++++ ++HP++ +++ Sbjct: 229 -SFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNS 266 >2HAK-A nrPDB Length = 328 Score = 112 bits (281), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 79/227 (34%), Positives = 117/227 (51%), Gaps = 19/227 (8%) Query: 100 KARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFT 159 K REV + + P+IV++ +V E K L +VME GGE+F + G Sbjct: 60 KLFREVRI-MKILNHPNIVKLFEVIET----EKTLYLVMEYASGGEVFDYLVAHG--RMK 112 Query: 160 EREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS 219 E+EA + I A+QY H I HRD+K ENLL + +K+ DFGF+ E T N Sbjct: 113 EKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDG---DMNIKIADFGFSNEFTVGNK 169 Query: 220 LTTPCYTPYYVAPEVLGPEKYDK-SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTR 278 L T C +P Y APE+ +KYD D+WSLGVI+Y L+ G PF + ++ R Sbjct: 170 LDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQN----LKELRER 225 Query: 279 IRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 + G+Y P +S + + L++ LL P +R ++ + M W+ Sbjct: 226 VLRGKYRIP----FYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWM 268 >4L42-A nrPDB Length = 346 Score = 112 bits (281), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 84/259 (32%), Positives = 133/259 (51%), Gaps = 29/259 (11%) Query: 68 QVLGLGINGKVLQI---FNKRTQEKFALKMLQDCPKARREVEL-HWRASQCPHIVR---- 119 +VLG G GKV Q+ T + FA+K+L+ R + H +A + +I+ Sbjct: 24 RVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAER--NILEEVKH 81 Query: 120 --IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL 177 IVD+ G K L +++E L GGELF +++ G F E A + I A+ +L Sbjct: 82 PFIVDLIYAFQTGGK-LYLILEYLSGGELFMQLEREG--IFMEDTACFYLAEISMALGHL 138 Query: 178 HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TPCYTPYYVAPEVLG 236 H I +RD+KPEN++ + +KLTDFG KE+ ++T T C T Y+APE+L Sbjct: 139 HQKGIIYRDLKPENIMLNHQ---GHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 195 Query: 237 PEKYDKSCDMWSLGVIMYILLCGYPPFYS-NHGLAISPGMKTRIRMGQYEFPNPEWSEVS 295 ++++ D WSLG +MY +L G PPF N I +K ++ + Y ++ Sbjct: 196 RSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPY---------LT 246 Query: 296 EEVKMLIRNLLKTEPTQRM 314 +E + L++ LLK R+ Sbjct: 247 QEARDLLKKLLKRNAASRL 265 >4RLP-A nrPDB Length = 288 Score = 111 bits (278), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 84/259 (32%), Positives = 133/259 (51%), Gaps = 29/259 (11%) Query: 68 QVLGLGINGKVLQI---FNKRTQEKFALKMLQDCPKARREVEL-HWRASQCPHIVR---- 119 +VLG G GKV Q+ T + FA+K+L+ R + H +A + +I+ Sbjct: 11 RVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAER--NILEEVKH 68 Query: 120 --IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL 177 IVD+ G K L +++E L GGELF +++ G F E A + I A+ +L Sbjct: 69 PFIVDLIYAFQTGGK-LYLILEYLSGGELFMQLEREG--IFMEDTACFYLAEISMALGHL 125 Query: 178 HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TPCYTPYYVAPEVLG 236 H I +RD+KPEN++ + +KLTDFG KE+ ++T T C T Y+APE+L Sbjct: 126 HQKGIIYRDLKPENIMLNHQ---GHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 182 Query: 237 PEKYDKSCDMWSLGVIMYILLCGYPPFYS-NHGLAISPGMKTRIRMGQYEFPNPEWSEVS 295 ++++ D WSLG +MY +L G PPF N I +K ++ + Y ++ Sbjct: 183 RSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPY---------LT 233 Query: 296 EEVKMLIRNLLKTEPTQRM 314 +E + L++ LLK R+ Sbjct: 234 QEARDLLKKLLKRNAASRL 252 >5F9E-A nrPDB Length = 353 Score = 110 bits (276), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 89/277 (32%), Positives = 133/277 (48%), Gaps = 35/277 (12%) Query: 52 LQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ----------DCPKA 101 LQIK I+D+++ ++LG G GKV K+T + FA+K L+ +C Sbjct: 12 LQIKLK--IEDFEL-HKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMV 68 Query: 102 -RREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTE 160 +R + L W H+ ENL+ VME L+GG+L IQ F Sbjct: 69 EKRVLSLAWEHPFLTHMFCTFQTKENLF-------FVMEYLNGGDLMYHIQ--SCHKFDL 119 Query: 161 REASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL 220 A+ I +Q+LHS I +RD+K +N+L + +K+ DFG KE ++ Sbjct: 120 SRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDK---DGHIKIADFGMCKENMLGDAK 176 Query: 221 TTP-CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRI 279 T C TP Y+APE+L +KY+ S D WS GV++Y +L G PF+ + I Sbjct: 177 TNEFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQD----EEELFHSI 232 Query: 280 RMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTI 316 RM + P W E +E K L+ L EP +R+ + Sbjct: 233 RMDNPFY--PRWLE--KEAKDLLVKLFVREPEKRLGV 265 >6C9D-A nrPDB Length = 459 Score = 110 bits (276), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 74/212 (34%), Positives = 110/212 (51%), Gaps = 18/212 (8%) Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 P+IV++ +V E K L +VME GGE+F + G E+EA + I A+ Sbjct: 80 PNIVKLFEVIET----EKTLYLVMEYASGGEVFDYLVAHG--RMKEKEARAKFRQIVSAV 133 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV 234 QY H I HRD+K ENLL + +K+ DFGF+ E T N L C +P Y APE+ Sbjct: 134 QYCHQKYIVHRDLKAENLLLDG---DMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPEL 190 Query: 235 LGPEKYDK-SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSE 293 +KYD D+WSLGVI+Y L+ G PF + ++ R+ G+Y P Sbjct: 191 FQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQN----LKELRERVLRGKYRIP----FY 242 Query: 294 VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 +S + + L++ LL P +R ++ + M W+ Sbjct: 243 MSTDCENLLKKLLVLNPIKRGSLEQIMKDRWM 274 >6ED6-A nrPDB Length = 415 Score = 109 bits (273), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 92/342 (26%), Positives = 156/342 (45%), Gaps = 51/342 (14%) Query: 51 GLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARR-EVELHW 109 GLQ+K +DY V +V+G G G+V + +K +Q+ +A+K+L +R + W Sbjct: 82 GLQMKA----EDYDVV-KVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFW 136 Query: 110 RA------SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREA 163 + P +V++ +++ + L +VME + GG+L + + + E+ A Sbjct: 137 EERDIMAFANSPWVVQLFYAFQD----DRYLYMVMEYMPGGDLVNLMSN---YDVPEKWA 189 Query: 164 SEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFG--FAKETTSHNSLT 221 + A+ +HS+ + HRDVKP+N+L + LKL DFG + T Sbjct: 190 KFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDK---HGHLKLADFGTCMKMDETGMVHCD 246 Query: 222 TPCYTPYYVAPEVL----GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKT 277 T TP Y++PEVL G Y + CD WS+GV +Y +L G PFY++ + G + Sbjct: 247 TAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLV----GTYS 302 Query: 278 RIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQ--RMTITEFMNHPWIMQSTKVPQTP 335 +I + PE +E+S+ K LI L + R + E HP+ Sbjct: 303 KIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPF----------- 351 Query: 336 LHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIED 377 K D+ W++++E + + D + IED Sbjct: 352 ------FKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIED 387 >1VZO-A nrPDB Length = 355 Score = 108 bits (270), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 87/265 (32%), Positives = 138/265 (52%), Gaps = 33/265 (12%) Query: 68 QVLGLGINGKVL---QIFNKRTQEKFALKMLQDCP-----------KARREVELHWRASQ 113 +VLG G GKV +I T + +A+K+L+ + R+V H R Q Sbjct: 60 KVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIR--Q 117 Query: 114 CPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEA 173 P +V + ++ L ++++ ++GGELF+ + R + FTE E + I A Sbjct: 118 SPFLVTLHYAFQT----ETKLHLILDYINGGELFTHLSQR--ERFTEHEVQIYVGEIVLA 171 Query: 174 IQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--LTTPCYTPYYVA 231 +++LH + I +RD+K EN+L S N + LTDFG +KE + + C T Y+A Sbjct: 172 LEHLHKLGIIYRDIKLENILLDS---NGHVVLTDFGLSKEFVADETERAYDFCGTIEYMA 228 Query: 232 PEVL--GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNP 289 P+++ G +DK+ D WSLGV+MY LL G PF + G S +R R+ + E P P Sbjct: 229 PDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVD-GEKNSQAEISR-RILKSEPPYP 286 Query: 290 EWSEVSEEVKMLIRNLLKTEPTQRM 314 + E+S K LI+ LL +P +R+ Sbjct: 287 Q--EMSALAKDLIQRLLMKDPKKRL 309 >5D9K-A nrPDB Length = 330 Score = 107 bits (268), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 78/258 (30%), Positives = 131/258 (50%), Gaps = 29/258 (11%) Query: 68 QVLGLGINGKVL---QIFNKRTQEKFALKMLQDCP-KARREVELHWRAS-----QCPHIV 118 +VLG G GKV +I ++ +A+K+L+ K R V P IV Sbjct: 36 KVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIV 95 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 ++ ++ G+ L ++++ L GG+LF+R+ + FTE + + + A+ +LH Sbjct: 96 KLHYAFQT--EGK--LYLILDFLRGGDLFTRLSK--EVMFTEEDVKFYLAELALALDHLH 149 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TPCYTPYYVAPEVLGP 237 S+ I +RD+KPEN+L + +KLTDFG +KE+ H + C T Y+APEV+ Sbjct: 150 SLGIIYRDLKPENILLDEE---GHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNR 206 Query: 238 EKYDKSCDMWSLGVIMYILLCGYPPFYS-NHGLAISPGMKTRIRMGQYEFPNPEWSEVSE 296 + +S D WS GV+M+ +L G PF + ++ +K ++ M Q+ +S Sbjct: 207 RGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQF---------LSP 257 Query: 297 EVKMLIRNLLKTEPTQRM 314 E + L+R L K P R+ Sbjct: 258 EAQSLLRMLFKRNPANRL 275 >4AF3-A nrPDB Length = 292 Score = 105 bits (261), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 82/285 (28%), Positives = 138/285 (48%), Gaps = 28/285 (9%) Query: 54 IKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP--------KARREV 105 + ++ IDD+++ + LG G G V K++ ALK+L + RRE+ Sbjct: 16 LTRHFTIDDFEI-GRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREI 74 Query: 106 ELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASE 165 E+ P+I+R+ N + R+ + +++E GEL+ +Q F E+ + Sbjct: 75 EIQAHLHH-PNILRLY----NYFYDRRRIYLILEYAPRGELYKELQK--SCTFDEQRTAT 127 Query: 166 IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY 225 IM+ + +A+ Y H + HRD+KPENLL K I DFG++ S T C Sbjct: 128 IMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKI---ADFGWSVHAPSLRR-KTMCG 183 Query: 226 TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE 285 T Y+ PE++ +++ D+W +GV+ Y LL G PPF S A RI + Sbjct: 184 TLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFES----ASHNETYRRIVKVDLK 239 Query: 286 FPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTK 330 FP + V + LI LL+ P++R+ + + HPW+ +++ Sbjct: 240 FP----ASVPTGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSR 280 >2F57-A nrPDB Length = 317 Score = 103 bits (258), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 77/262 (29%), Positives = 133/262 (50%), Gaps = 22/262 (8%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRA-SQCPHIVRIVDVYENLY 128 +G G G V K T ++ A+K + + RRE+ + + H +VD+Y + Sbjct: 53 IGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYL 112 Query: 129 AGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVK 188 G + L +VME L+GG L + E + + + S+ A+ YLH+ + HRD+K Sbjct: 113 VGDE-LWVVMEFLEGGALTDIVTH---TRMNEEQIATVCLSVLRALSYLHNQGVIHRDIK 168 Query: 189 PENLLYTSKRPNAILKLTDFGF----AKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSC 244 +++L TS + +KL+DFGF +KE SL TPY++APEV+ Y Sbjct: 169 SDSILLTS---DGRIKLSDFGFCAQVSKEVPKRKSLVG---TPYWMAPEVISRLPYGTEV 222 Query: 245 DMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN-PEWSEVSEEVKMLIR 303 D+WSLG+++ ++ G PP+++ P ++ R+ P + +VS ++ + Sbjct: 223 DIWSLGIMVIEMIDGEPPYFNE------PPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLD 276 Query: 304 NLLKTEPTQRMTITEFMNHPWI 325 +L EP+QR T E + HP++ Sbjct: 277 LMLVREPSQRATAQELLGHPFL 298 >6QAU-A nrPDB Length = 280 Score = 103 bits (257), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 57/160 (35%), Positives = 90/160 (56%), Gaps = 12/160 (7%) Query: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 Q +IV + DV E + +VME +GG+L +Q +G +E + I Sbjct: 68 QHENIVALYDVQEL----PNSVFLVMEYCNGGDLADYLQAKG--TLSEDTIRVFLHQIAA 121 Query: 173 AIQYLHSINIAHRDVKPENLL--YTSKRPNAI----LKLTDFGFAKETTSHNSLTTPCYT 226 A++ LHS I HRD+KP+N+L Y ++R +++ +K+ DFGFA+ S+ C + Sbjct: 122 AMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGS 181 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSN 266 P Y+APEV+ + YD D+WS+G ++Y L G PPF +N Sbjct: 182 PMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQAN 221 >5FET-A nrPDB Length = 847 Score = 103 bits (256), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 75/233 (32%), Positives = 120/233 (51%), Gaps = 26/233 (11%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEKFALKML----------QDCPKARREVELHWRASQCP 115 T +++G G G V + +K TQ ++ALK + Q+ K RE+ + P Sbjct: 537 TERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAE---NDHP 593 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 I+R+V +++ C + E + GGEL+ I+ G ++ +A + SI AI+ Sbjct: 594 FIIRLVRTFKD----SNCFYFLTELVTGGELYDAIRKLG--LLSKPQAQFYLGSIILAIE 647 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL 235 YLH NI +RD+KPEN+L + +KL DFG AK+ T TP+Y+APEV+ Sbjct: 648 YLHERNIVYRDLKPENILLDKQ---GYVKLIDFGCAKKI--QGRAYTLVGTPHYMAPEVI 702 Query: 236 GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN 288 + Y + D+W+LGV +Y +CG PF ++ + + I GQ FP+ Sbjct: 703 LGKGYGCTVDIWALGVCLYEFICGPLPFGNDQEDQLE--IFRDILTGQLTFPD 753 >2Z7Q-A nrPDB Length = 321 Score = 103 bits (256), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 75/258 (29%), Positives = 131/258 (50%), Gaps = 29/258 (11%) Query: 68 QVLGLGINGKVL---QIFNKRTQEKFALKMLQDCP-----KARREVELHWRAS-QCPHIV 118 +VLG G GKV ++ + +A+K+L+ + R ++E A P +V Sbjct: 34 KVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVV 93 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 ++ ++ G+ L ++++ L GG+LF+R+ + FTE + + + + +LH Sbjct: 94 KLHYAFQT--EGK--LYLILDFLRGGDLFTRLSK--EVMFTEEDVKFYLAELALGLDHLH 147 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TPCYTPYYVAPEVLGP 237 S+ I +RD+KPEN+L + +KLTDFG +KE H + C T Y+APEV+ Sbjct: 148 SLGIIYRDLKPENILLDEE---GHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNR 204 Query: 238 EKYDKSCDMWSLGVIMYILLCGYPPFYS-NHGLAISPGMKTRIRMGQYEFPNPEWSEVSE 296 + + S D WS GV+M+ +L G PF + ++ +K ++ M Q+ +S Sbjct: 205 QGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQF---------LST 255 Query: 297 EVKMLIRNLLKTEPTQRM 314 E + L+R L K P R+ Sbjct: 256 EAQSLLRALFKRNPANRL 273 >4KS7-A nrPDB Length = 292 Score = 102 bits (253), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 79/272 (29%), Positives = 143/272 (52%), Gaps = 36/272 (13%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELH----WRASQCPHIVRIVDVYE 125 +G G G V K + + A+KM+ + RRE+ + R Q H +V++Y+ Sbjct: 31 IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQ--HF-NVVEMYK 87 Query: 126 NLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHR 185 + G + L ++ME L GG L + E + + + +++ +A+ YLH+ + HR Sbjct: 88 SYLVGEE-LWVLMEFLQGGALTDIV---SQVRLNEEQIATVCEAVLQALAYLHAQGVIHR 143 Query: 186 DVKPENLLYTSKRPNAILKLTDFGF----AKETTSHNSLTTPCYTPYYVAPEVLGPEKYD 241 D+K +++L T + +KL+DFGF +K+ SL TPY++APEV+ Y Sbjct: 144 DIKSDSILLTL---DGRVKLSDFGFCAQISKDVPKRKSLVG---TPYWMAPEVISRSLYA 197 Query: 242 KSCDMWSLGVIMYILLCGYPPFYSNHGLAISP--GMKTRIRMGQYEFPNPEWS---EVSE 296 D+WSLG+++ ++ G PP++S+ SP MK R+R + P P+ +VS Sbjct: 198 TEVDIWSLGIMVIEMVDGEPPYFSD-----SPVQAMK-RLR----DSPPPKLKNSHKVSP 247 Query: 297 EVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328 ++ + +L +P +R T E ++HP+++Q+ Sbjct: 248 VLRDFLERMLVRDPQERATAQELLDHPFLLQT 279 >6E9W-A nrPDB Length = 443 Score = 101 bits (252), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 86/319 (26%), Positives = 152/319 (47%), Gaps = 42/319 (13%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARR-EVELHWRA------SQ 113 +DY+V +V+G G G+V + +K T++ +A+K+L +R + W + Sbjct: 102 EDYEVV-KVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFAN 160 Query: 114 CPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEA 173 P +V++ +++ + L +VME + GG+L + + + E+ A + A Sbjct: 161 SPWVVQLFYAFQD----DRYLYMVMEYMPGGDLVNLMSN---YDVPEKWARFYTAEVVLA 213 Query: 174 IQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL--TTPCYTPYYVA 231 + +HS+ HRDVKP+N+L + LKL DFG + + T TP Y++ Sbjct: 214 LDAIHSMGFIHRDVKPDNMLLDK---SGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYIS 270 Query: 232 PEVL----GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 PEVL G Y + CD WS+GV +Y +L G PFY++ + G ++I + Sbjct: 271 PEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLV----GTYSKIMNHKNSLT 326 Query: 288 NPEWSEVSEEVKMLIRNLLKTEPTQ--RMTITE------FMNHPW---IMQSTKVPQTPL 336 P+ +++S+E K LI L + R + E F N W ++ T P P Sbjct: 327 FPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPD 386 Query: 337 HTSRVLKEDKERWEDVKEE 355 +S + D ++D++E+ Sbjct: 387 LSSDI---DTSNFDDLEED 402 >2OU7-A nrPDB Length = 335 Score = 100 bits (250), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 79/265 (29%), Positives = 123/265 (46%), Gaps = 27/265 (10%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVELHWRASQCPHIVRIV 121 LG G K +I + T+E FA K++ K E+ +H R+ H+V Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIH-RSLAHQHVVG-- 105 Query: 122 DVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN 181 + + + +V+E L + R +A TE EA ++ I QYLH Sbjct: 106 --FHGFFEDNDFVFVVLELCRRRSLLELHKRR--KALTEPEARYYLRQIVLGCQYLHRNR 161 Query: 182 IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TPCYTPYYVAPEVLGPEKY 240 + HRD+K NL + +K+ DFG A + C TP Y+APEVL + + Sbjct: 162 VIHRDLKLGNLFLNE---DLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGH 218 Query: 241 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 300 D+WS+G IMY LL G PPF + S +T +R+ + E+ P+ ++ Sbjct: 219 SFEVDVWSIGCIMYTLLVGKPPFET------SCLKETYLRIKKNEYSIPK--HINPVAAS 270 Query: 301 LIRNLLKTEPTQRMTITEFMNHPWI 325 LI+ +L+T+PT R TI E +N + Sbjct: 271 LIQKMLQTDPTARPTINELLNDEFF 295 >6FD3-A nrPDB Length = 300 Score = 100 bits (250), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 77/261 (29%), Positives = 130/261 (49%), Gaps = 20/261 (7%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKM--LQDCPKARREVE--LHWRASQCPHIVRIVDVYE 125 +G G +G V + T ++ A+K LQ PK + L R ++ P+IV +D Y Sbjct: 30 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY- 88 Query: 126 NLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHR 185 G + L +VME L GG L + + E + + + + +A+ +LHS + HR Sbjct: 89 --LVGDE-LWVVMEYLAGGSLTDVVTE---TCMDEGQIAAVCRECLQALDFLHSNQVIHR 142 Query: 186 DVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS-LTTPCYTPYYVAPEVLGPEKYDKSC 244 D+K +N+L + +KLTDFGF + T S +T TPY++APEV+ + Y Sbjct: 143 DIKSDNILLGM---DGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKV 199 Query: 245 DMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRN 304 D+WSLG++ ++ G PP+ + + L + T G E NPE +S + + Sbjct: 200 DIWSLGIMAIEMVEGEPPYLNENPLRALYLIATN---GTPELQNPE--RLSAVFRDFLNR 254 Query: 305 LLKTEPTQRMTITEFMNHPWI 325 L+ + +R + E + HP++ Sbjct: 255 CLEMDVDRRGSAKELLQHPFL 275 >3DB8-A nrPDB Length = 317 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 77/268 (28%), Positives = 123/268 (45%), Gaps = 27/268 (10%) Query: 67 SQVLGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVELHWRASQCPHIV 118 + LG G K +I + T+E FA K++ K E+ +H ++ PH+V Sbjct: 47 GRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIH-KSLDNPHVV 105 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 + + + +V+E L + R +A TE EA M+ + +QYLH Sbjct: 106 G----FHGFFEDDDFVYVVLEICRRRSLLELHKRR--KAVTEPEARYFMRQTIQGVQYLH 159 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTP-CYTPYYVAPEVLGP 237 + + HRD+K NL + +K+ DFG A + C TP Y+APEVL Sbjct: 160 NNRVIHRDLKLGNLFLND---DMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLCK 216 Query: 238 EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEE 297 + + D+WSLG I+Y LL G PPF + S +T IR+ + E+ P ++ Sbjct: 217 KGHSFEVDIWSLGCILYTLLVGKPPFET------SCLKETYIRIKKNEYSVPR--HINPV 268 Query: 298 VKMLIRNLLKTEPTQRMTITEFMNHPWI 325 LIR +L +PT R ++ E + + Sbjct: 269 ASALIRRMLHADPTLRPSVAELLTDEFF 296 >4J52-A nrPDB Length = 293 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 79/265 (29%), Positives = 123/265 (46%), Gaps = 27/265 (10%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVELHWRASQCPHIVRIV 121 LG G K +I + T+E FA K++ K E+ +H R+ H+V Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIH-RSLAHQHVVG-- 78 Query: 122 DVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN 181 + + + +V+E L + R +A TE EA ++ I QYLH Sbjct: 79 --FHGFFEDNDFVFVVLELCRRRSLLELHKRR--KALTEPEARYYLRQIVLGCQYLHRNR 134 Query: 182 IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TPCYTPYYVAPEVLGPEKY 240 + HRD+K NL + +K+ DFG A + C TP Y+APEVL + + Sbjct: 135 VIHRDLKLGNLFLNE---DLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGH 191 Query: 241 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 300 D+WS+G IMY LL G PPF + S +T +R+ + E+ P+ ++ Sbjct: 192 SFEVDVWSIGCIMYTLLVGKPPFET------SCLKETYLRIKKNEYSIPK--HINPVAAS 243 Query: 301 LIRNLLKTEPTQRMTITEFMNHPWI 325 LI+ +L+T+PT R TI E +N + Sbjct: 244 LIQKMLQTDPTARPTINELLNDEFF 268 >5DYK-A nrPDB Length = 853 Score = 100 bits (248), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 75/252 (29%), Positives = 129/252 (51%), Gaps = 26/252 (10%) Query: 47 HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML----------Q 96 H++ ++++ + D T +++G G G V + +K T+ ++ALK + Q Sbjct: 524 HLEERIKMQDTKVEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQ 583 Query: 97 DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQ 156 + K RE+ + P I+R+V +++ K + E + GGEL+ I+ G Sbjct: 584 NNIKLEREITAE---NDHPFIIRLVRTFKD----SKYFYFLTELVTGGELYDAIRKLG-- 634 Query: 157 AFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS 216 ++ +A + SI AI+YLH NI +RD+KPEN+L + +KL DFG AK+ Sbjct: 635 LLSKSQAQFYLGSIILAIEYLHERNIVYRDLKPENILLDKQ---GYVKLIDFGCAKKV-- 689 Query: 217 HNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMK 276 T TP+Y+APEV+ + Y + D+W+LG+ +Y +CG PF ++ + + Sbjct: 690 QGRAYTLVGTPHYMAPEVILGKGYGCTVDIWALGICLYEFICGPLPFGNDEEDQLE--IF 747 Query: 277 TRIRMGQYEFPN 288 I GQ FP+ Sbjct: 748 RDILTGQLTFPD 759 >3TXO-A nrPDB Length = 353 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 79/271 (29%), Positives = 130/271 (47%), Gaps = 23/271 (8%) Query: 51 GLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-DCPKARREVELHW 109 G+ ID+++ +VLG G GKV+ K T + +A+K+L+ D +VE Sbjct: 13 GVNSSNRLGIDNFEFI-RVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTM 71 Query: 110 RASQCPHIVRIVDVYENLYAGRKC---LLIVMECLDGGELFSRIQD--RGDQAFTEREAS 164 + + R L+ + L VME ++GG+L IQ R D+A A+ Sbjct: 72 TEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAA 131 Query: 165 EIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TP 223 EI+ A+ +LH I +RD+K +N+L + KL DFG KE + T T Sbjct: 132 EIIS----ALMFLHDKGIIYRDLKLDNVLLDHE---GHCKLADFGMCKEGICNGVTTATF 184 Query: 224 CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQ 283 C TP Y+APE+L Y + D W++GV++Y +LCG+ PF + + + + Sbjct: 185 CGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILND----- 239 Query: 284 YEFPNPEWSEVSEEVKMLIRNLLKTEPTQRM 314 E P W + E+ ++++ + PT R+ Sbjct: 240 -EVVYPTW--LHEDATGILKSFMTKNPTMRL 267 >5LOH-A nrPDB Length = 341 Score = 97.4 bits (241), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 68/212 (32%), Positives = 106/212 (50%), Gaps = 20/212 (9%) Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 IV +Y +L + L VME L GG++ S + G F E A + + + A+ YLH Sbjct: 96 IVHLYYSLQSANNVYL-VMEYLIGGDVKSLLHIYG--YFDEEMAVKYISEVALALDYLHR 152 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN-------SLTTPCYTPYYVAP 232 I HRD+KP+N+L +++ +KLTDFG +K T + + + T C TP Y+AP Sbjct: 153 HGIIHRDLKPDNMLISNE---GHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAP 209 Query: 233 EVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWS 292 E+L + + D W+LGV ++ L G PPF + + R + P PE Sbjct: 210 ELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKR------DIPWPEGE 263 Query: 293 E-VSEEVKMLIRNLLKTEPTQRMTITEFMNHP 323 E +S+ + + LL + T+R + E HP Sbjct: 264 EKLSDNAQSAVEILLTIDDTKRAGMKELKRHP 295 >3A8W-A nrPDB Length = 345 Score = 97.4 bits (241), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 65/205 (31%), Positives = 106/205 (51%), Gaps = 18/205 (8%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVELHWRASQCPHIVR 119 +V+G G KVL + K+T +A+K++ +D + E + +AS P +V Sbjct: 15 RVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVG 74 Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 + ++ L V+E ++GG+L +Q + + E A I A+ YLH Sbjct: 75 LHSCFQT----ESRLFFVIEYVNGGDLMFHMQRQ--RKLPEEHARFYSAEISLALNYLHE 128 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS-HNSLTTPCYTPYYVAPEVLGPE 238 I +RD+K +N+L S+ +KLTD+G KE ++ +T C TP Y+APE+L E Sbjct: 129 RGIIYRDLKLDNVLLDSE---GHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGE 185 Query: 239 KYDKSCDMWSLGVIMYILLCGYPPF 263 Y S D W+LGV+M+ ++ G PF Sbjct: 186 DYGFSVDWWALGVLMFEMMAGRSPF 210 >3Q53-A nrPDB Length = 306 Score = 97.1 bits (240), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 75/261 (28%), Positives = 131/261 (50%), Gaps = 20/261 (7%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKM--LQDCPKARREVE--LHWRASQCPHIVRIVDVYE 125 +G G +G V + T ++ A++ LQ PK + L R ++ P+IV +D Y Sbjct: 29 IGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY- 87 Query: 126 NLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHR 185 G + L +VME L GG L + + E + + + + +A+++LHS + HR Sbjct: 88 --LVGDE-LWVVMEYLAGGSLTDVVTE---TCMDEGQIAAVCRECLQALEFLHSNQVIHR 141 Query: 186 DVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS-LTTPCYTPYYVAPEVLGPEKYDKSC 244 D+K +N+L + +KLTDFGF + T S +T TPY++APEV+ + Y Sbjct: 142 DIKSDNILLGM---DGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKV 198 Query: 245 DMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRN 304 D+WSLG++ ++ G PP+ + + L + T G E NPE ++S + + Sbjct: 199 DIWSLGIMAIEMIEGEPPYLNENPLRALYLIATN---GTPELQNPE--KLSAIFRDFLNR 253 Query: 305 LLKTEPTQRMTITEFMNHPWI 325 L+ + +R + E + H ++ Sbjct: 254 CLEMDVEKRGSAKELIQHQFL 274 >4FIE-A nrPDB Length = 423 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 83/313 (26%), Positives = 149/313 (47%), Gaps = 36/313 (11%) Query: 32 PAQPPPP-PPQQFPQFHVKSGLQIKKNAIID-----DYKVTSQVLGLGINGKVLQIFNKR 85 P +PP P PQ+ PQ + ++D Y +G G G V + Sbjct: 115 PEKPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRS 174 Query: 86 TQEKFALKMLQDCPKARREVELH----WRASQCPHIVRIVDVYENLYAGRKCLLIVMECL 141 + + A+K + + RRE+ + R Q ++V ++Y + G + L +VME L Sbjct: 175 SGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVV---EMYNSYLVGDE-LWVVMEFL 230 Query: 142 DGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNA 201 +GG L + E + + + ++ +A+ LH+ + HRD+K +++L T + Sbjct: 231 EGGALTDIVTH---TRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTH---DG 284 Query: 202 ILKLTDFGF----AKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILL 257 +KL+DFGF +KE SL TPY++APE++ Y D+WSLG+++ ++ Sbjct: 285 RVKLSDFGFCAQVSKEVPRRKSLVG---TPYWMAPELISRLPYGPEVDIWSLGIMVIEMV 341 Query: 258 CGYPPFYSNHGLAISPGMKTRIRMGQYEFPN--PEWSEVSEEVKMLIRNLLKTEPTQRMT 315 G PP+++ P +K ++M + P +VS +K + LL +P QR T Sbjct: 342 DGEPPYFNE------PPLKA-MKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRAT 394 Query: 316 ITEFMNHPWIMQS 328 E + HP++ ++ Sbjct: 395 AAELLKHPFLAKA 407 >4RA4-A nrPDB Length = 355 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 68/206 (33%), Positives = 104/206 (50%), Gaps = 22/206 (10%) Query: 69 VLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCP----HIVRIVDVY 124 VLG G GKV+ K T+E +A+K+L +++V + +C ++ ++D Sbjct: 27 VLGKGSFGKVMLADRKGTEELYAIKIL------KKDVVIQDDDVECTMVEKRVLALLDKP 80 Query: 125 ENLYAGRKC------LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 L C L VME ++GG+L IQ G F E +A I + +LH Sbjct: 81 PFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVG--KFKEPQAVFYAAEISIGLFFLH 138 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TPCYTPYYVAPEVLGP 237 I +RD+K +N++ S+ +K+ DFG KE T T C TP Y+APE++ Sbjct: 139 KRGIIYRDLKLDNVMLDSE---GHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAY 195 Query: 238 EKYDKSCDMWSLGVIMYILLCGYPPF 263 + Y KS D W+ GV++Y +L G PPF Sbjct: 196 QPYGKSVDWWAYGVLLYEMLAGQPPF 221 >4QMW-A nrPDB Length = 310 Score = 95.9 bits (237), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 83/294 (28%), Positives = 139/294 (47%), Gaps = 31/294 (10%) Query: 48 VKSGLQIKKNAIIDDYKVTSQV--LGLGINGKVLQIFNKRTQEKFALKMLQ------DCP 99 V+SGL +N D ++ +++ +G G G+V + + RTQ+ A+K++ + Sbjct: 13 VQSGLPGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIE 72 Query: 100 KARREVELHWRASQC--PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQA 157 ++E+ + SQC P++ + Y Y L I+ME L GG ++ Sbjct: 73 DIQQEITV---LSQCDSPYVTK----YYGSYLKDTKLWIIMEYLGGGSALDLLEP---GP 122 Query: 158 FTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTS 216 E + + I++ I + + YLHS HRD+K N+L + + +KL DFG A + T + Sbjct: 123 LDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSE---HGEVKLADFGVAGQLTDT 179 Query: 217 HNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMK 276 T TP+++APEV+ YD D+WSLG+ L G PP H MK Sbjct: 180 QIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELH------PMK 233 Query: 277 TRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTK 330 + + P E S+ +K + L EP+ R T E + H +I+++ K Sbjct: 234 VLFLIPKNNPPTLE-GNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAK 286 >2BRG-A nrPDB Length = 297 Score = 95.5 bits (236), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 82/278 (29%), Positives = 132/278 (47%), Gaps = 30/278 (10%) Query: 59 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-----DCPK-ARREVELHWRAS 112 ++D+ + Q LG G G+V N+ T+E A+K++ DCP+ ++E+ + + Sbjct: 5 FVEDWDLV-QTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICI----N 59 Query: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 + + +V Y + G L + C GGELF RI+ D E +A + Sbjct: 60 KMLNHENVVKFYGHRREGNIQYLFLEYC-SGGELFDRIEP--DIGMPEPDAQRFFHQLMA 116 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS---LTTPCYTPYY 229 + YLH I I HRD+KPENLL +R N LK++DFG A +N L C T Y Sbjct: 117 GVVYLHGIGITHRDIKPENLL-LDERDN--LKISDFGLATVFRYNNRERLLNKMCGTLPY 173 Query: 230 VAPEVLGPEKYDKS-CDMWSLGVIMYILLCGYPPFY--SNHGLAISPGMKTRIRMGQYEF 286 VAPE+L ++ D+WS G+++ +L G P+ S+ S + + + Sbjct: 174 VAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKT------Y 227 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPW 324 NP W ++ L+ +L P+ R+TI + W Sbjct: 228 LNP-WKKIDSAPLALLHKILVENPSARITIPDIKKDRW 264 >6BXI-A nrPDB Length = 333 Score = 95.5 bits (236), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 72/246 (29%), Positives = 115/246 (46%), Gaps = 47/246 (19%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHI-- 117 ++D++ + +V+G G G+V + K T +A+K+L+ +E H RA + + Sbjct: 5 LEDFE-SLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEA 63 Query: 118 --VRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 + +V ++ + + + L ++ME L GG++ + + + TE E + AI Sbjct: 64 DSLWVVKMFYS-FQDKLNLYLIMEFLPGGDMMTLLMKK--DTLTEEETQFYIAETVLAID 120 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGF------AKETTSHNSLT-------- 221 +H + HRD+KP+NLL SK +KL+DFG A T + +L Sbjct: 121 SIHQLGFIHRDIKPDNLLLDSK---GHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFT 177 Query: 222 ----------------------TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCG 259 + TP Y+APEV Y+K CD WSLGVIMY +L G Sbjct: 178 FQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIG 237 Query: 260 YPPFYS 265 YPPF S Sbjct: 238 YPPFCS 243 >4JDH-A nrPDB Length = 346 Score = 95.5 bits (236), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 83/313 (26%), Positives = 149/313 (47%), Gaps = 36/313 (11%) Query: 32 PAQPPPP-PPQQFPQFHVKSGLQIKKNAIID-----DYKVTSQVLGLGINGKVLQIFNKR 85 P +PP P PQ+ PQ + ++D Y +G G G V + Sbjct: 38 PEKPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRS 97 Query: 86 TQEKFALKMLQDCPKARREVELH----WRASQCPHIVRIVDVYENLYAGRKCLLIVMECL 141 + + A+K + + RRE+ + R Q ++V ++Y + G + L +VME L Sbjct: 98 SGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVV---EMYNSYLVGDE-LWVVMEFL 153 Query: 142 DGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNA 201 +GG L + E + + + ++ +A+ LH+ + HRD+K +++L T + Sbjct: 154 EGGALTDIVTH---TRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTH---DG 207 Query: 202 ILKLTDFGF----AKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILL 257 +KL+DFGF +KE SL TPY++APE++ Y D+WSLG+++ ++ Sbjct: 208 RVKLSDFGFCAQVSKEVPRRKSLVG---TPYWMAPELISRLPYGPEVDIWSLGIMVIEMV 264 Query: 258 CGYPPFYSNHGLAISPGMKTRIRMGQYEFP--NPEWSEVSEEVKMLIRNLLKTEPTQRMT 315 G PP+++ P +K ++M + P +VS +K + LL +P QR T Sbjct: 265 DGEPPYFN------EPPLKA-MKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRAT 317 Query: 316 ITEFMNHPWIMQS 328 E + HP++ ++ Sbjct: 318 AAELLKHPFLAKA 330 >3COM-A nrPDB Length = 314 Score = 95.1 bits (235), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 79/269 (29%), Positives = 127/269 (47%), Gaps = 24/269 (8%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKML---QDCPKARREVELHWRASQC--PHIVRIVDVY 124 LG G G V + +K T + A+K + D + +E+ + QC PH+V+ Y Sbjct: 37 LGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISI---MQQCDSPHVVK----Y 89 Query: 125 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 184 Y L IVME G + I+ R ++ TE E + I++S + ++YLH + H Sbjct: 90 YGSYFKNTDLWIVMEYCGAGSVSDIIRLR-NKTLTEDEIATILQSTLKGLEYLHFMRKIH 148 Query: 185 RDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYYVAPEVLGPEKYDKS 243 RD+K N+L ++ KL DFG A + T + T TP+++APEV+ Y+ Sbjct: 149 RDIKAGNILLNTE---GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCV 205 Query: 244 CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE-WSEVSEEVKMLI 302 D+WSLG+ + G PP+ H + + T F PE WS+ + + Sbjct: 206 ADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTN---PPPTFRKPELWSDNFTD---FV 259 Query: 303 RNLLKTEPTQRMTITEFMNHPWIMQSTKV 331 + L P QR T T+ + HP++ + V Sbjct: 260 KQCLVKSPEQRATATQLLQHPFVRSAKGV 288 >4KIK-B nrPDB Length = 677 Score = 95.1 bits (235), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 65/207 (31%), Positives = 105/207 (50%), Gaps = 12/207 (5%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQD--CPKARR----EVELHWRASQCPHIVRIVDV 123 LG G G V++ N+ T E+ A+K + P+ R E+++ R + P++V DV Sbjct: 27 LGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTH-PNVVAARDV 85 Query: 124 YENL--YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREAS--EIMKSIGEAIQYLHS 179 E + A L+ ME GG+L + ++ + RE + ++ I A++YLH Sbjct: 86 PEGMQNLAPNDLPLLAMEYCQGGDLRKYL-NQFENCCGLREGAILTLLSDIASALRYLHE 144 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEK 239 I HRD+KPEN++ I K+ D G+AKE + T+ T Y+APE+L +K Sbjct: 145 NRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQK 204 Query: 240 YDKSCDMWSLGVIMYILLCGYPPFYSN 266 Y + D WS G + + + G+ PF N Sbjct: 205 YTVTVDYWSFGTLAFECITGFRPFLPN 231 >6CCF-A nrPDB Length = 290 Score = 94.4 bits (233), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 54/177 (30%), Positives = 93/177 (52%), Gaps = 13/177 (7%) Query: 155 DQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET 214 D+ F+E +A ++ + ++YLH I HRD+KP NLL + +K+ DFG + + Sbjct: 123 DKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGD---DGHVKIADFGVSNQF 179 Query: 215 TSHNS-LTTPCYTPYYVAPEVL---GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLA 270 +++ L++ TP ++APE + G K+ D+W+ GV +Y + G PF + LA Sbjct: 180 EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA 239 Query: 271 ISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 + +K + PE E+SEE+K LI +L P R+ + + HPW+ + Sbjct: 240 LHRKIKNEPVV------FPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTK 290 >4WNO-A nrPDB Length = 287 Score = 94.4 bits (233), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 50/134 (37%), Positives = 77/134 (57%), Gaps = 8/134 (5%) Query: 136 IVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT 195 +VME +GG+L + + +E ++ I A++ LHS I HRD+KP+N+L + Sbjct: 94 LVMEYCNGGDLADYLHAM--RTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLS 151 Query: 196 S-----KRPNAI-LKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSL 249 + PN+I +K+ DFGFA+ S+ T C +P Y+APEV+ + YD D+WS+ Sbjct: 152 NPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSI 211 Query: 250 GVIMYILLCGYPPF 263 G I+Y L G PF Sbjct: 212 GTIVYQCLTGKAPF 225 >2Q0N-A nrPDB Length = 301 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 62/215 (28%), Positives = 113/215 (52%), Gaps = 23/215 (10%) Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 +V++Y + G + L +VME L+GG L + E + + + ++ +A+ LH+ Sbjct: 88 VVEMYNSYLVGDE-LWVVMEFLEGGALTDIVTH---TRMNEEQIAAVCLAVLQALSVLHA 143 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGF----AKETTSHNSLTTPCYTPYYVAPEVL 235 + HRD+K +++L T + +KL+DFGF +KE SL TPY++APE++ Sbjct: 144 QGVIHRDIKSDSILLTH---DGRVKLSDFGFCAQVSKEVPRRKSLVG---TPYWMAPELI 197 Query: 236 GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP--NPEWSE 293 Y D+WSLG+++ ++ G PP+++ P +K ++M + P + Sbjct: 198 SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNE------PPLKA-MKMIRDNLPPRLKNLHK 250 Query: 294 VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328 VS +K + LL +P QR T E + HP++ ++ Sbjct: 251 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKA 285 >6CMJ-A nrPDB Length = 321 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 73/292 (25%), Positives = 139/292 (47%), Gaps = 34/292 (11%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ---------DCPKARREVELHWR 110 +D Y + ++ G G G V +N+ +A+K+L C + R +E ++ Sbjct: 33 LDQYTLKDEI-GKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQ 91 Query: 111 ASQC------PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREAS 164 P++V++V+V ++ L +V E ++ G + ++ + +E +A Sbjct: 92 EIAILKKLDHPNVVKLVEVLDD--PNEDHLYMVFELVNQGPV---MEVPTLKPLSEDQAR 146 Query: 165 EIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL-TTP 223 + + + I+YLH I HRD+KP NLL + +K+ DFG + E ++L + Sbjct: 147 FYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGE---DGHIKIADFGVSNEFKGSDALLSNT 203 Query: 224 CYTPYYVAPEVLGPEK---YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIR 280 TP ++APE L + K+ D+W++GV +Y + G PF + + ++I+ Sbjct: 204 VGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMC----LHSKIK 259 Query: 281 MGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVP 332 EFP+ +++E++K LI +L P R+ + E HPW+ + P Sbjct: 260 SQALEFPDQ--PDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEP 309 >4B6L-A nrPDB Length = 281 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 81/284 (28%), Positives = 122/284 (42%), Gaps = 33/284 (11%) Query: 65 VTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR--------REVELHWRASQCPH 116 + ++LG G + + + T +A+K++ A+ E+ELH R Q H Sbjct: 12 LKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELH-RDLQHRH 70 Query: 117 IVRIVDVYE---NLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEA 173 IVR +E N+Y I +E L + R E E ++ I Sbjct: 71 IVRFSHHFEDADNIY-------IFLELCSRKSLAHIWKAR--HTLLEPEVRYYLRQILSG 121 Query: 174 IQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS-HNSLTTPCYTPYYVAP 232 ++YLH I HRD+K N T N LK+ DFG A T C TP YVAP Sbjct: 122 LKYLHQRGILHRDLKLGNFFITE---NMELKVGDFGLAARLEPPEQRKKTICGTPNYVAP 178 Query: 233 EVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWS 292 EVL + + D+WSLG +MY LLCG PPF + A I+ Y P + Sbjct: 179 EVLLRQGHGPEADVWSLGCVMYTLLCGSPPFET----ADLKETYRCIKQVHYTLP----A 230 Query: 293 EVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPL 336 +S + L+ +L+ P R +I + + H + + + P+ Sbjct: 231 SLSLPARQLLAAILRASPRDRPSIDQILRHDFFTKGYTPDRLPI 274 >4XBR-A nrPDB Length = 366 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 62/215 (28%), Positives = 113/215 (52%), Gaps = 23/215 (10%) Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 +V++Y + G + L +VME L+GG L + E + + + ++ +A+ LH+ Sbjct: 153 VVEMYNSYLVGDE-LWVVMEFLEGGALTDIVTH---TRMNEEQIAAVCLAVLQALSVLHA 208 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGF----AKETTSHNSLTTPCYTPYYVAPEVL 235 + HRD+K +++L T + +KL+DFGF +KE SL TPY++APE++ Sbjct: 209 QGVIHRDIKSDSILLTH---DGRVKLSDFGFCAQVSKEVPRRKSLVG---TPYWMAPELI 262 Query: 236 GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP--NPEWSE 293 Y D+WSLG+++ ++ G PP+++ P +K ++M + P + Sbjct: 263 SRLPYGPEVDIWSLGIMVIEMVDGEPPYFN------EPPLKA-MKMIRDNLPPRLKNLHK 315 Query: 294 VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328 VS +K + LL +P QR T E + HP++ ++ Sbjct: 316 VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKA 350 >4APC-A nrPDB Length = 350 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 70/271 (25%), Positives = 125/271 (46%), Gaps = 23/271 (8%) Query: 65 VTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQCPHI 117 V Q +G G GK + + + ++ +K + ++ ++RREV + P+I Sbjct: 27 VRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH-PNI 85 Query: 118 VRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL 177 V+ + +E L IVM+ +GG+LF RI + F E + + I A++++ Sbjct: 86 VQYRESFEE----NGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHV 141 Query: 178 HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY-TPYYVAPEVLG 236 H I HRD+K +N+ T + ++L DFG A+ S L C TPYY++PE+ Sbjct: 142 HDRKILHRDIKSQNIFLT---KDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEICE 198 Query: 237 PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSE 296 + Y+ D+W+LG ++Y LC H +++ FP P S Sbjct: 199 NKPYNNKSDIWALGCVLY-ELCTL-----KHAFEAGSMKNLVLKIISGSFP-PVSLHYSY 251 Query: 297 EVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 +++ L+ L K P R ++ + +I + Sbjct: 252 DLRSLVSQLFKRNPRDRPSVNSILEKGFIAK 282 >4AW2-A nrPDB Length = 437 Score = 92.0 bits (227), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 83/289 (28%), Positives = 138/289 (47%), Gaps = 44/289 (15%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD----------CPKARREVELHWR 110 +D+++ +V+G G G+V + K + FA+K+L C + R+V ++ Sbjct: 74 EDFEIL-KVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGD 132 Query: 111 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELF---SRIQDRGDQAFTEREASEIM 167 + + NLY +VM+ GG+L S+ +DR E A + Sbjct: 133 SKWITTLHYAFQDDNNLY-------LVMDYYVGGDLLTLLSKFEDR----LPEEMARFYL 181 Query: 168 KSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFG----FAKETTSHNSLTTP 223 + AI +H ++ HRD+KP+N+L N ++L DFG ++ T +S+ Sbjct: 182 AEMVIAIDSVHQLHYVHRDIKPDNILMDM---NGHIRLADFGSCLKLMEDGTVQSSVAVG 238 Query: 224 CYTPYYVAPEVL-----GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTR 278 TP Y++PE+L G +Y CD WSLGV MY +L G PFY+ L + G K Sbjct: 239 --TPDYISPEILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYA-ESLVETYG-KIM 294 Query: 279 IRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQ--RMTITEFMNHPWI 325 +++FP + ++VSE K LIR L+ + + + I +F HP+ Sbjct: 295 NHKERFQFPT-QVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFF 342 >3BGP-A nrPDB Length = 333 Score = 90.9 bits (224), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 66/193 (34%), Positives = 92/193 (47%), Gaps = 27/193 (13%) Query: 145 ELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILK 204 +LF I +RG A E A + EA+++ H+ + HRD+K EN+L R LK Sbjct: 148 DLFDFITERG--ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGE--LK 203 Query: 205 LTDFG---FAKETTSHNSLTTPCYTPYYVAPEVLGPEKY-DKSCDMWSLGVIMYILLCGY 260 L DFG K+T + T Y+P PE + +Y +S +WSLG+++Y ++CG Sbjct: 204 LIDFGSGALLKDTVYTDFDGTRVYSP----PEWIRYHRYHGRSAAVWSLGILLYDMVCGD 259 Query: 261 PPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM 320 PF + I GQ F VS E + LIR L P+ R T E Sbjct: 260 IPFEHD----------EEIIRGQVFFRQ----RVSSECQHLIRWCLALRPSDRPTFEEIQ 305 Query: 321 NHPWIMQSTKVPQ 333 NHPW MQ +PQ Sbjct: 306 NHPW-MQDVLLPQ 317 >3PFQ-A nrPDB Length = 674 Score = 90.9 bits (224), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 71/220 (32%), Positives = 104/220 (47%), Gaps = 14/220 (6%) Query: 53 QIKKNAIIDDYKVTS----QVLGLGINGKVLQIFNKRTQEKFALKMLQ-DCPKARREVE- 106 + N D K+T VLG G GKV+ K T E +A+K+L+ D +VE Sbjct: 328 KFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVEC 387 Query: 107 --LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREAS 164 + R P + + + L VME ++GG+L IQ G F E A Sbjct: 388 TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG--RFKEPHAV 445 Query: 165 EIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TP 223 I + +L S I +RD+K +N++ S+ +K+ DFG KE T T Sbjct: 446 FYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSE---GHIKIADFGMCKENIWDGVTTKTF 502 Query: 224 CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPF 263 C TP Y+APE++ + Y KS D W+ GV++Y +L G PF Sbjct: 503 CGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPF 542 >2I0E-A nrPDB Length = 353 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 67/200 (33%), Positives = 98/200 (49%), Gaps = 10/200 (5%) Query: 69 VLGLGINGKVLQIFNKRTQEKFALKMLQ-DCPKARREVE---LHWRASQCPHIVRIVDVY 124 VLG G GKV+ K T E +A+K+L+ D +VE + R P + Sbjct: 27 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQL 86 Query: 125 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 184 + + L VME ++GG+L IQ G F E A I + +L S I + Sbjct: 87 HSCFQTMDRLYFVMEYVNGGDLMYHIQQVG--RFKEPHAVFYAAEIAIGLFFLQSKGIIY 144 Query: 185 RDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TPCYTPYYVAPEVLGPEKYDKS 243 RD+K +N++ S+ +K+ DFG KE T T C TP Y+APE++ + Y KS Sbjct: 145 RDLKLDNVMLDSE---GHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS 201 Query: 244 CDMWSLGVIMYILLCGYPPF 263 D W+ GV++Y +L G PF Sbjct: 202 VDWWAFGVLLYEMLAGQAPF 221 >5TUR-A nrPDB Length = 404 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 66/193 (34%), Positives = 92/193 (47%), Gaps = 27/193 (13%) Query: 145 ELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILK 204 +LF I +RG A E A + EA+++ H+ + HRD+K EN+L R LK Sbjct: 219 DLFDFITERG--ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGE--LK 274 Query: 205 LTDFG---FAKETTSHNSLTTPCYTPYYVAPEVLGPEKY-DKSCDMWSLGVIMYILLCGY 260 L DFG K+T + T Y+P PE + +Y +S +WSLG+++Y ++CG Sbjct: 275 LIDFGSGALLKDTVYTDFDGTRVYSP----PEWIRYHRYHGRSAAVWSLGILLYDMVCGD 330 Query: 261 PPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM 320 PF + I GQ F VS E + LIR L P+ R T E Sbjct: 331 IPFEHD----------EEIIRGQVFFRQ----RVSSECQHLIRWCLALRPSDRPTFEEIQ 376 Query: 321 NHPWIMQSTKVPQ 333 NHPW MQ +PQ Sbjct: 377 NHPW-MQDVLLPQ 388 >4RC3-A nrPDB Length = 289 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 66/193 (34%), Positives = 92/193 (47%), Gaps = 27/193 (13%) Query: 145 ELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILK 204 +LF I +RG A E A + EA+++ H+ + HRD+K EN+L R LK Sbjct: 104 DLFDFITERG--ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGE--LK 159 Query: 205 LTDFG---FAKETTSHNSLTTPCYTPYYVAPEVLGPEKY-DKSCDMWSLGVIMYILLCGY 260 L DFG K+T + T Y+P PE + +Y +S +WSLG+++Y ++CG Sbjct: 160 LIDFGSGALLKDTVYTDFDGTRVYSP----PEWIRYHRYHGRSAAVWSLGILLYDMVCGD 215 Query: 261 PPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM 320 PF + I GQ F VS E + LIR L P+ R T E Sbjct: 216 IPFEHD----------EEIIRGQVFFRQ----RVSSECQHLIRWCLALRPSDRPTFEEIQ 261 Query: 321 NHPWIMQSTKVPQ 333 NHPW MQ +PQ Sbjct: 262 NHPW-MQDVLLPQ 273 >3TKU-A nrPDB Length = 433 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 79/284 (27%), Positives = 138/284 (48%), Gaps = 34/284 (11%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD----------CPKARREVELHWR 110 +D+++ +V+G G G+V + K T+ +A+K+L C + R+V ++ Sbjct: 90 EDFEII-KVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVN-- 146 Query: 111 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 C I + +++ L +VM+ GG+L + + D+ E A + + Sbjct: 147 -GDCQWITALHYAFQD----ENHLYLVMDYYVGGDLLTLLSKFEDK-LPEDMARFYIGEM 200 Query: 171 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL--TTPCYTPY 228 AI +H ++ HRD+KP+N+L N ++L DFG + ++ + TP Sbjct: 201 VLAIDSIHQLHYVHRDIKPDNVLLD---VNGHIRLADFGSCLKMNDDGTVQSSVAVGTPD 257 Query: 229 YVAPEVL-----GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQ 283 Y++PE+L G KY CD WSLGV MY +L G PFY+ L + G K + Sbjct: 258 YISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAE-SLVETYG-KIMNHEER 315 Query: 284 YEFPNPEWSEVSEEVKMLIRNLLKTEPTQ--RMTITEFMNHPWI 325 ++FP+ ++VSEE K LI+ L+ + + + I +F H + Sbjct: 316 FQFPS-HVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFF 358 >6AO5-A nrPDB Length = 362 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 76/263 (28%), Positives = 124/263 (47%), Gaps = 24/263 (9%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKML---QDCPKARREVELHWRASQC--PHIVRIVDVY 124 LG G G V + +K + + A+K + D + +E+ + QC P++V+ Y Sbjct: 18 LGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISI---MQQCDSPYVVK----Y 70 Query: 125 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 184 Y L IVME G + I+ R ++ E E + I+KS + ++YLH + H Sbjct: 71 YGSYFKNTDLWIVMEYCGAGSVSDIIRLR-NKTLIEDEIATILKSTLKGLEYLHFMRKIH 129 Query: 185 RDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYYVAPEVLGPEKYDKS 243 R++K N+L ++ KL DFG A + T + T TP+++APEV+ Y+ Sbjct: 130 RNIKAGNILLNTE---GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCV 186 Query: 244 CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE-WSEVSEEVKMLI 302 D+WSLG+ + G PP+ H + + T F PE W S++ + Sbjct: 187 ADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTN---PPPTFRKPELW---SDDFTDFV 240 Query: 303 RNLLKTEPTQRMTITEFMNHPWI 325 + L P QR T T+ + HP+I Sbjct: 241 KKCLVKNPEQRATATQLLQHPFI 263 >4LG4-A nrPDB Length = 299 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 76/263 (28%), Positives = 124/263 (47%), Gaps = 24/263 (9%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKML---QDCPKARREVELHWRASQC--PHIVRIVDVY 124 LG G G V + +K + + A+K + D + +E+ + QC P++V+ Y Sbjct: 19 LGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISI---MQQCDSPYVVK----Y 71 Query: 125 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 184 Y L IVME G + I+ R ++ E E + I+KS + ++YLH + H Sbjct: 72 YGSYFKNTDLWIVMEYCGAGSVSDIIRLR-NKTLIEDEIATILKSTLKGLEYLHFMRKIH 130 Query: 185 RDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYYVAPEVLGPEKYDKS 243 R++K N+L ++ KL DFG A + T + T TP+++APEV+ Y+ Sbjct: 131 RNIKAGNILLNTE---GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCV 187 Query: 244 CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE-WSEVSEEVKMLI 302 D+WSLG+ + G PP+ H + + T F PE W S++ + Sbjct: 188 ADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTN---PPPTFRKPELW---SDDFTDFV 241 Query: 303 RNLLKTEPTQRMTITEFMNHPWI 325 + L P QR T T+ + HP+I Sbjct: 242 KKCLVKNPEQRATATQLLQHPFI 264 >5YV8-A nrPDB Length = 298 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 59/215 (27%), Positives = 111/215 (51%), Gaps = 18/215 (8%) Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 P++V++V+V ++ L +V E ++ G + ++ + +E +A + + + I Sbjct: 96 PNVVKLVEVLDD--PNEDHLYMVFELVNQGPV---MEVPTLKPLSEDQARFYFQDLIKGI 150 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL-TTPCYTPYYVAPE 233 +YLH I HRD+KP NLL + +K+ DFG + E ++L + TP ++APE Sbjct: 151 EYLHYQKIIHRDIKPSNLLVGE---DGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPE 207 Query: 234 VLGPEK---YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE 290 L + K+ D+W++GV +Y + G PF + + ++I+ EFP+ Sbjct: 208 SLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMC----LHSKIKSQALEFPDQ- 262 Query: 291 WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 +++E++K LI +L P R+ + E HPW+ Sbjct: 263 -PDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 296 >4EQM-A nrPDB Length = 294 Score = 88.6 bits (218), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 64/192 (33%), Positives = 96/192 (50%), Gaps = 24/192 (12%) Query: 102 RREVELHWRASQCPH--IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFT 159 R E E+H +SQ H IV ++DV E C +VME ++G L I+ G + Sbjct: 57 RFEREVH-NSSQLSHQNIVSMIDVDEE----DDCYYLVMEYIEGPTLSEYIESHG--PLS 109 Query: 160 EREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS 219 A I + I++ H + I HRD+KP+N+L S N LK+ DFG AK S S Sbjct: 110 VDTAINFTNQILDGIKHAHDMRIVHRDIKPQNILIDS---NKTLKIFDFGIAK-ALSETS 165 Query: 220 LTTPCY---TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAIS---- 272 LT + T Y +PE E D+ D++S+G+++Y +L G PPF ++I+ Sbjct: 166 LTQTNHVLGTVQYFSPEQAKGEATDECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHI 225 Query: 273 ----PGMKTRIR 280 P + T +R Sbjct: 226 QDSVPNVTTDVR 237 >4FZF-B nrPDB Length = 283 Score = 88.2 bits (217), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 73/268 (27%), Positives = 123/268 (45%), Gaps = 25/268 (9%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQ------DCPKARREVELHWRASQCPHIVRIVDV 123 +G G G+V + + RTQ+ A+K++ + ++E+ + SQC V Sbjct: 16 IGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITV---LSQCDS--SYVTK 70 Query: 124 YENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIA 183 Y Y L I+ME L GG ++ F E + + ++K I + + YLHS Sbjct: 71 YYGSYLKGSKLWIIMEYLGGGSALDLLRA---GPFDEFQIATMLKEILKGLDYLHSEKKI 127 Query: 184 HRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYYVAPEVLGPEKYDK 242 HRD+K N+L + + +KL FG A + T + T TP+++APEV+ YD Sbjct: 128 HRDIKAANVLLSEQGD---VKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDS 184 Query: 243 SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI 302 D+WSLG+ L G PP H + + + + P + ++ K I Sbjct: 185 KADIWSLGITAIELAKGEPPNSDMHPMRV-------LFLIPKNNPPTLVGDFTKSFKEFI 237 Query: 303 RNLLKTEPTQRMTITEFMNHPWIMQSTK 330 L +P+ R T E + H +I++++K Sbjct: 238 DACLNKDPSFRPTAKELLKHKFIVKNSK 265 >4I6B-A nrPDB Length = 308 Score = 88.2 bits (217), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 72/272 (26%), Positives = 123/272 (45%), Gaps = 29/272 (10%) Query: 67 SQVLGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVELHWRASQCPHIV 118 + LG G K ++ + + +A K++ K +E+ELH R H+V Sbjct: 33 GKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELH-RILHHKHVV 91 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 + +E+ ++ + I++E + ++ R + TE E ++ I ++YLH Sbjct: 92 QFYHYFED----KENIYILLEYCSRRSMAHILKAR--KVLTEPEVRYYLRQIVSGLKYLH 145 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCYTPYYVAPEVLG 236 I HRD+K N LK+ DFG A E H T C TP Y++PEVL Sbjct: 146 EQEILHRDLKLGNFFINESME---LKVGDFGLAARLEPLEHRRRTI-CGTPNYLSPEVLN 201 Query: 237 PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSE 296 + + D+W+LG +MY +L G PPF + + + ++ IR +Y P S + Sbjct: 202 KQGHGAESDIWALGCVMYTMLLGRPPFETTN---LKETYRS-IREARYTMP----SSLLA 253 Query: 297 EVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328 K LI ++L P R ++ + + H + Q Sbjct: 254 PAKHLIASMLSKNPEDRPSLDDIIRHDFFTQG 285 >6E2O-A nrPDB Length = 295 Score = 87.8 bits (216), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 76/272 (27%), Positives = 129/272 (47%), Gaps = 15/272 (5%) Query: 69 VLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIV-RIVDVYENL 127 VLG G G V + Q + A+K + + +R LH + H+ + + Y Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEIPE-RDSRYSQPLHEEIALHKHLKHKNIVQYLGS 87 Query: 128 YAGRKCLLIVMECLDGGELFSRIQDR-GDQAFTEREASEIMKSIGEAIQYLHSINIAHRD 186 ++ + I ME + GG L + ++ + G E+ K I E ++YLH I HRD Sbjct: 88 FSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRD 147 Query: 187 VKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TPCYTPYYVAPEVL--GPEKYDKS 243 +K +N+L + + +LK++DFG +K N T T T Y+APE++ GP Y K+ Sbjct: 148 IKGDNVLINTY--SGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKA 205 Query: 244 CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSE-VSEEVKMLI 302 D+WSLG + + G PPFY + ++G ++ +PE E +S E K I Sbjct: 206 ADIWSLGCTIIEMATGKPPFYE-----LGEPQAAMFKVGMFKV-HPEIPESMSAEAKAFI 259 Query: 303 RNLLKTEPTQRMTITEFMNHPWIMQSTKVPQT 334 + +P +R + + ++ S+K +T Sbjct: 260 LKCFEPDPDKRACANDLLVDEFLKVSSKKKKT 291 >2UV2-A nrPDB Length = 325 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 88/298 (29%), Positives = 142/298 (47%), Gaps = 30/298 (10%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQDCPKARRE---VELHWRAS-QCPHIVRIVDV-- 123 LG G GKV + NK T A K++ + E VE+ AS P+IV+++D Sbjct: 45 LGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFY 104 Query: 124 YENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIA 183 YEN L I++E GG + + + + ++ TE + + K +A+ YLH I Sbjct: 105 YEN------NLWILIEFCAGGAVDAVMLEL-ERPLTESQIQVVCKQTLDALNYLHDNKII 157 Query: 184 HRDVKPENLLYTSKRPNAILKLTDFGF-AKETTSHNSLTTPCYTPYYVAPEVLGPEK--- 239 HRD+K N+L+T + +KL DFG AK T + + TPY++APEV+ E Sbjct: 158 HRDLKAGNILFT---LDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKD 214 Query: 240 --YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN-PEWSEVSE 296 YD D+WSLG+ + + PP + ++P M+ +++ + E P + S S Sbjct: 215 RPYDYKADVWSLGITLIEMAEIEPPHHE-----LNP-MRVLLKIAKSEPPTLAQPSRWSS 268 Query: 297 EVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKE 354 K ++ L+ R T ++ + HP++ + P L + E E ED KE Sbjct: 269 NFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIREL-IAEAKAEVTEEVEDGKE 325 >2WQN-A nrPDB Length = 310 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 78/301 (25%), Positives = 136/301 (45%), Gaps = 31/301 (10%) Query: 23 PPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIF 82 PP P A P F ++ +I + + Y+ + G+ + K +QIF Sbjct: 11 PPVPQFQPQKALRPDMGYNTLANFRIEK--KIGRGQFSEVYRAACLLDGVPVALKKVQIF 68 Query: 83 NKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLD 142 + + A DC K E++L + + P++++ Y + L IV+E D Sbjct: 69 DLMDAKARA-----DCIK---EIDLLKQLNH-PNVIK----YYASFIEDNELNIVLELAD 115 Query: 143 GGELFSRIQDRGDQA--FTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPN 200 G+L I+ Q ER + + A++++HS + HRD+KP N+ T+ Sbjct: 116 AGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITA---T 172 Query: 201 AILKLTDFG----FAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYIL 256 ++KL D G F+ +TT+ +SL TPYY++PE + Y+ D+WSLG ++Y + Sbjct: 173 GVVKLGDLGLGRFFSSKTTAAHSLVG---TPYYMSPERIHENGYNFKSDIWSLGCLLYEM 229 Query: 257 LCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTI 316 PFY + S K Q ++P SEE++ L+ + +P +R + Sbjct: 230 AALQSPFYGDKMNLYSLCKKIE----QCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDV 285 Query: 317 T 317 T Sbjct: 286 T 286 >3ORZ-A nrPDB Length = 316 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 80/277 (28%), Positives = 130/277 (46%), Gaps = 46/277 (16%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD--------CPKARREVELHWRAS 112 +D+K ++LG G V+ T ++A+K+L+ P RE ++ R Sbjct: 37 EDFKF-GKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLD 95 Query: 113 QCPHIVRIVDVY---ENLYAGRKCLLIVMECLDGGELFSRIQDRG--DQAFTEREASEIM 167 P V++ + E LY G + GEL I+ G D+ T +EI+ Sbjct: 96 H-PFFVKLYFCFQDDEKLYFG-------LSYAKNGELLKYIRKIGSFDETCTRFYTAEIV 147 Query: 168 KSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK------ETTSHNSLT 221 A++YLH I HRD+KPEN+L + +++TDFG AK + NS Sbjct: 148 S----ALEYLHGKGIIHRDLKPENILLNE---DMHIQITDFGTAKVLSPESKQARANSFV 200 Query: 222 TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRM 281 T YV+PE+L + KS D+W+LG I+Y L+ G PPF + + I + I++ Sbjct: 201 G---TAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLI---FQKIIKL 254 Query: 282 GQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITE 318 +Y+FP + + + L+ LL + T+R+ E Sbjct: 255 -EYDFPEKFFPKARD----LVEKLLVLDATKRLGCEE 286 >5CEK-A nrPDB Length = 263 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 57/188 (30%), Positives = 97/188 (51%), Gaps = 16/188 (8%) Query: 142 DGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNA 201 D G++ S ++ R + E EA+ + K I A+ + H I D+K +++++ Sbjct: 83 DFGDMHSYVRSR--KRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQ 140 Query: 202 IL--KLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY--DKSCDMWSLGVIMYILL 257 + L D K ++L+ P YV+PE+L K+ D+WSLGV++Y LL Sbjct: 141 LRLESLEDTHIMK--GEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLL 198 Query: 258 CGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTIT 317 G PF+ + A+ ++IR GQ+ P +S + + LIR+LL+ EP++R+T Sbjct: 199 VGRYPFHDSDPSALF----SKIRRGQFCIPE----HISPKARCLIRSLLRREPSERLTAP 250 Query: 318 EFMNHPWI 325 E + HPW Sbjct: 251 EILLHPWF 258 >6DTL-A nrPDB Length = 364 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 70/229 (30%), Positives = 107/229 (46%), Gaps = 22/229 (9%) Query: 50 SGLQIKKNAIIDDYKVTSQV------LGLGINGKVLQIFNKRTQEKFALKMLQ------- 96 G I+ N + ++VT++ +G G G V N T E A+K + Sbjct: 12 GGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKI 71 Query: 97 DCPKARREVELHWRASQCPHIVRIVDVYEN-LYAGRKCLLIVMECLDGGELFSRIQDRGD 155 D + RE++L R +IV I D+ L + I E +D +L I R + Sbjct: 72 DAKRTLREIKL-LRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQII--RSN 127 Query: 156 QAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT 215 QA +E + I ++Y+HS N+ HRD+KP NLL + N LK+ DFG A+ T+ Sbjct: 128 QALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNA---NCDLKICDFGLARVTS 184 Query: 216 SHNSLTTPCYTPYYVAPE-VLGPEKYDKSCDMWSLGVIMYILLCGYPPF 263 + +T T +Y APE +L Y + D+WS+G I L+ P F Sbjct: 185 ESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLF 233 >6DC0-A nrPDB Length = 292 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 57/188 (30%), Positives = 97/188 (51%), Gaps = 16/188 (8%) Query: 142 DGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNA 201 D G++ S ++ R + E EA+ + K I A+ + H I D+K +++++ Sbjct: 80 DFGDMHSYVRSR--KRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQ 137 Query: 202 IL--KLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY--DKSCDMWSLGVIMYILL 257 + L D K ++L+ P YV+PE+L K+ D+WSLGV++Y LL Sbjct: 138 LRLESLEDTHIMK--GEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLL 195 Query: 258 CGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTIT 317 G PF+ + A + ++IR GQ+ P +S + + LIR+LL+ EP++R+T Sbjct: 196 VGRYPFHDSDPSA----LFSKIRRGQFCIPE----HISPKARCLIRSLLRREPSERLTAP 247 Query: 318 EFMNHPWI 325 E + HPW Sbjct: 248 EILLHPWF 255 >5L2Q-C nrPDB Length = 320 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 60/200 (30%), Positives = 98/200 (49%), Gaps = 18/200 (9%) Query: 131 RKCLLIVMECLDGGELFSRIQDR--------GDQAFTEREASEIMKSIGEAIQYLHSINI 182 +K + +V++CL + + D ++ +ERE I + ++ LH NI Sbjct: 115 KKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSERETVVIFYDVVRVVEALHQKNI 174 Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY-TPYYVAPEVLGPEKY- 240 HRD+K N++ +KR + I +T+F K S L +P Y++P+VL Y Sbjct: 175 VHRDLKLGNMVL-NKRTHRI-TITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYR 232 Query: 241 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 300 K DMW+LGV+++ +L G PFY +I + +I+ +Y PE VSE Sbjct: 233 GKPSDMWALGVVLFTMLYGQFPFYD----SIPQELFRKIKAAEYTI--PEDGRVSENTVC 286 Query: 301 LIRNLLKTEPTQRMTITEFM 320 LIR LL +P QR+ + + Sbjct: 287 LIRKLLVLDPQQRLAAADVL 306 >5J5T-A nrPDB Length = 370 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 74/272 (27%), Positives = 122/272 (44%), Gaps = 28/272 (10%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKML-----QDCPKARREVELHWRASQCPHIVRIVD 122 Q +G G G V + N T E A+K++ +D ++E+ + + + P+IV Sbjct: 10 QRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEI-IMMKDCKHPNIV---- 64 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182 Y Y R L I ME GG L G +E + + + + + + YLHS Sbjct: 65 AYFGSYLRRDKLWICMEFCGGGSLQDIYHVTG--PLSELQIAYVSRETLQGLYYLHSKGK 122 Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY-TPYYVAPEVLGPEK-- 239 HRD+K N+L T N +KL DFG + + T+ + TPY++APEV E+ Sbjct: 123 MHRDIKGANILLTD---NGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKG 179 Query: 240 -YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV---S 295 Y++ CD+W++G+ L PP + H M+ M + F P+ + S Sbjct: 180 GYNQLCDLWAVGITAIELAELQPPMFDLH------PMRALFLMTKSNFQPPKLKDKMKWS 233 Query: 296 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 ++ L P +R T + + HP++ Q Sbjct: 234 NSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQ 265 >3QA8-A nrPDB Length = 676 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 64/206 (31%), Positives = 100/206 (48%), Gaps = 10/206 (4%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQD--CPKARR----EVELHWRASQCPHIVRIVDV 123 LG G G VL+ ++ T E+ A+K + PK R E+++ + + P++V +V Sbjct: 22 LGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKLNH-PNVVSAREV 80 Query: 124 YENL--YAGRKCLLIVMECLDGGELFSRI-QDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 + L A L+ ME +GG+L + Q E ++ I A++YLH Sbjct: 81 PDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSALRYLHEN 140 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY 240 I HRD+KPEN++ I K+ D G+AKE T T Y+APE+L +KY Sbjct: 141 RIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPELLEQKKY 200 Query: 241 DKSCDMWSLGVIMYILLCGYPPFYSN 266 + D WS G + + + G+ PF N Sbjct: 201 TVTVDYWSFGTLAFECITGFRPFLPN 226 >5AIR-A nrPDB Length = 430 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 81/287 (28%), Positives = 130/287 (45%), Gaps = 33/287 (11%) Query: 67 SQVLGLGINGKVLQIFNKRTQEKFALK-MLQDCPKARREVELHWRASQCPHIVRIVDVYE 125 ++V+G G G V Q + E A+K +LQD RE+++ + C +IVR+ + Sbjct: 69 TKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHC-NIVRLRYFFY 127 Query: 126 NLYAGRK----CLLIVMECL-DGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 + +G K L +V++ + + +R R Q M + ++ Y+HS Sbjct: 128 S--SGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF 185 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPE-VLGPEK 239 I HRD+KP+NLL A+LKL DFG AK+ + + YY APE + G Sbjct: 186 GICHRDIKPQNLLLDPD--TAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATD 243 Query: 240 YDKSCDMWSLGVIMYILLCGYPPFYSNHGL--------AISPGMKTRIR-----MGQYEF 286 Y S D+WS G ++ LL G P F + G+ + + +IR +++F Sbjct: 244 YTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKF 303 Query: 287 PNPE---WSEVSE-----EVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 P + W++V E L LL+ PT R+T E H + Sbjct: 304 PQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 350 >2XIK-A nrPDB Length = 294 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 79/273 (28%), Positives = 121/273 (44%), Gaps = 35/273 (12%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQ------DCPKARREVELHWRASQC--PHIVRIV 121 +G G G+V + + T+E A+K++ + ++E+ + SQC P+I R Sbjct: 27 IGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITV---LSQCDSPYITR-- 81 Query: 122 DVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN 181 Y Y L I+ME L GG ++ E + I++ I + + YLHS Sbjct: 82 --YFGSYLKSTKLWIIMEYLGGGSALDLLKP---GPLEETYIATILREILKGLDYLHSER 136 Query: 182 IAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYYVAPEVLGPEKY 240 HRD+K N+L + + +KL DFG A + T + T TP+++APEV+ Y Sbjct: 137 KIHRDIKAANVLLSEQ---GDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAY 193 Query: 241 DKSCDMWSLGVIMYILLCGYPPFYSNH---GLAISPGMKTRIRMGQYEFPNPEWSEVSEE 297 D D+WSLG+ L G PP H L + P GQ+ P E+ E Sbjct: 194 DFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEAC-- 251 Query: 298 VKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTK 330 L +P R T E + H +I + TK Sbjct: 252 --------LNKDPRFRPTAKELLKHKFITRYTK 276 >5Z33-A nrPDB Length = 425 Score = 84.3 bits (207), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 91/352 (25%), Positives = 154/352 (43%), Gaps = 73/352 (20%) Query: 54 IKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD-------CPKARREVE 106 ++ I+D+ ++ LG G G V N +T E A+K + + +A RE++ Sbjct: 23 FNQDFIVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIK 82 Query: 107 L--HWRASQCPHIVRIVDV-----YENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFT 159 L H+R + + +D+ + Y + +MEC +L + I R Q T Sbjct: 83 LLQHFRGHRNITCLYDMDIPRPDNFNETYLYEE----LMEC----DLAAII--RSGQPLT 132 Query: 160 EREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT---- 215 + + I ++Y+HS N+ HRD+KP NLL + + LK+ DFG A+ + Sbjct: 133 DAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNA---DCELKICDFGLARGFSVDPE 189 Query: 216 -SHNSLTTPCYTPYYVAPEV-LGPEKYDKSCDMWSLGVIMYILLCGYPPFYS-------N 266 + +T T +Y APE+ L + Y K+ D+WS+G I+ LL G P F N Sbjct: 190 ENAGYMTEYVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLN 249 Query: 267 HGLAI--SPGMKTRIRMG-----QYE--------------FPNPEWSEVSEEVKMLIRNL 305 L I +P +T R+G +Y FPN + + L+ + Sbjct: 250 QILHILGTPNEETLSRIGSPRAQEYVRNLPFMAKKPFPTLFPN-----ANPDALDLLDRM 304 Query: 306 LKTEPTQRMTITEFMNHPWI---MQSTKVPQTPLHTSRVLKEDKERWEDVKE 354 L +P+ R+++ + + HP++ ++ P P D E EDV E Sbjct: 305 LAFDPSSRISVEQALEHPYLHIWHDASDEPDCPT----TFNFDFEVVEDVGE 352 >4BGQ-A nrPDB Length = 304 Score = 84.3 bits (207), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 83/293 (28%), Positives = 128/293 (43%), Gaps = 53/293 (18%) Query: 69 VLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYE--N 126 V+G G G VL+ +K T E A+K +D + E R + ++ ++ E Sbjct: 19 VVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKE 78 Query: 127 LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRD 186 + R L +V E ++ + +++ + E+ S I + I +AI + H +I HRD Sbjct: 79 AFRRRGKLYLVFEYVEKN-MLELLEEMPNGVPPEKVKSYIYQLI-KAIHWCHKNDIVHRD 136 Query: 187 VKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT--TPCYTPYYVAPEVLGPEKYDKSC 244 +KPENLL + N +LKL DFGFA+ + N+ T +Y +PE+L Y KS Sbjct: 137 IKPENLLISH---NDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGAPYGKSV 193 Query: 245 DMWSLGVIMYILLCGYP---------------------------PFYSN---HGLAI--- 271 DMWS+G I+ L G P FYSN HGL Sbjct: 194 DMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAV 253 Query: 272 -SPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHP 323 P R +G ++ + L++NLLK +P R + +NHP Sbjct: 254 NHPQSLERRYLGI----------LNSVLLDLMKNLLKLDPADRYLTEQCLNHP 296 >5ZTN-A nrPDB Length = 429 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 63/218 (28%), Positives = 108/218 (49%), Gaps = 12/218 (5%) Query: 50 SGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARR----EV 105 S +Q+ + + Y+V +V+G G G+V++ ++ + + ALKM+++ + R E+ Sbjct: 86 SYVQVPHDHVAYRYEVL-KVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEI 144 Query: 106 EL--HWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREA 163 + H R + + ++ + EN + R + + E L L+ I+ Q F+ Sbjct: 145 RILEHLRKQDKDNTMNVIHMLEN-FTFRNHICMTFELLSM-NLYELIKKNKFQGFSLPLV 202 Query: 164 SEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTP 223 + SI + + LH I H D+KPEN+L + + I K+ DFG H + T Sbjct: 203 RKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGI-KVIDFG--SSCYEHQRVYTY 259 Query: 224 CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYP 261 + +Y APEV+ +Y DMWSLG I+ LL GYP Sbjct: 260 IQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYP 297 >5VO2-A nrPDB Length = 300 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 77/287 (26%), Positives = 132/287 (45%), Gaps = 25/287 (8%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVEL-HWRASQCPHIVRIVDVYEN 126 Q +G G G V + E+ A+K ++D +E ++ H R + P+I+ ++ Sbjct: 18 QWVGSGAQGAVF--LGRFHGEEVAVKKVRDL----KETDIKHLRKLKHPNII----TFKG 67 Query: 127 LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRD 186 + C I+ME G+L+ + R + T + I + YLH I HRD Sbjct: 68 VCTQAPCYCILMEFCAQGQLYEVL--RAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRD 125 Query: 187 VKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDM 246 +K N+L T + ++K++DFG +KE + ++ + T ++APEV+ E + D+ Sbjct: 126 LKSPNMLITY---DDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDI 182 Query: 247 WSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLL 306 WS GV+++ LL G P+ AI G+ + P P S + K+L+R Sbjct: 183 WSFGVVLWELLTGEIPYKDVDSSAIIWGVGSN----SLHLPVP--SSCPDGFKILLRQCW 236 Query: 307 KTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVK 353 ++P R + + + H + S V TP T K E E+VK Sbjct: 237 NSKPRNRPSFRQILLHL-DIASADVLSTPQET--YFKSQAEWREEVK 280 >3EB0-A nrPDB Length = 383 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 85/318 (26%), Positives = 140/318 (44%), Gaps = 63/318 (19%) Query: 67 SQVLGLGINGKVLQIFNKRTQEKFALK-MLQDCPKARREVELHWRASQCPHIVRIVDVY- 124 + LG G G V ++F+ + ++FALK +LQD RE+++ + +I+++VD + Sbjct: 12 GKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKNRELDI-MKVLDHVNIIKLVDYFY 70 Query: 125 ---------------ENLYAGR------------------KCLLIVMECL-DGGELFSRI 150 N G+ K L ++ME + D + Sbjct: 71 TTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPDTLHKVLKS 130 Query: 151 QDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGF 210 R ++ S + + A+ ++HS+ I HRD+KP+NLL SK + LKL DFG Sbjct: 131 FIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSK--DNTLKLCDFGS 188 Query: 211 AKETT-SHNSLTTPCYTPYYVAPEV-LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHG 268 AK+ S S+ C + +Y APE+ LG +Y S D+WS+G + L+ G P F Sbjct: 189 AKKLIPSEPSVAYIC-SRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGKPLFSGETS 247 Query: 269 ---------LAISPGMKTRIRMG----QYEFPN---PEWSEVSEE-----VKMLIRNLLK 307 + +P + IRM + FP +W ++ E L+ +L+ Sbjct: 248 IDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKILPEGTPSLAIDLLEQILR 307 Query: 308 TEPTQRMTITEFMNHPWI 325 EP R+ E M HP+ Sbjct: 308 YEPDLRINPYEAMAHPFF 325 >4YHJ-A nrPDB Length = 584 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 53/187 (28%), Positives = 90/187 (48%), Gaps = 7/187 (3%) Query: 128 YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDV 187 Y + L +V+ ++GG+L I + G+ F E+ A + ++ L I +RD+ Sbjct: 254 YETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDL 313 Query: 188 KPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMW 247 KPEN+L + ++++D G A E + T Y+APEV+ EKY S D W Sbjct: 314 KPENILLDDR---GHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWW 370 Query: 248 SLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLK 307 LG ++Y ++ G+ PF + RI+ E+ + SE+ K + R LL Sbjct: 371 GLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYS----EKFSEDAKSICRMLLT 426 Query: 308 TEPTQRM 314 P++R+ Sbjct: 427 KNPSKRL 433 >5O0Y-A nrPDB Length = 579 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 81/309 (26%), Positives = 138/309 (44%), Gaps = 28/309 (9%) Query: 41 QQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK 100 ++ + H + Q K + ++D + +LG G +V + F+ Q A+K+ Q Sbjct: 263 RELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKN 322 Query: 101 ARREVELHWRASQCPHIV--------RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQD 152 R E + ++ C RIV +Y+ V+E +G +L ++ Sbjct: 323 WRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQ 382 Query: 153 RGDQAFTEREASEIMKSIGEAIQYLHSIN--IAHRDVKPENLLYTSKRPNAILKLTDFGF 210 + +E+EA I+ I A++YL+ I I H D+KP N+L + +K+TDFG Sbjct: 383 H--KLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGL 440 Query: 211 AK--ETTSHNSL------TTPCYTPYYVAPE--VLGPE--KYDKSCDMWSLGVIMYILLC 258 +K + S+NS+ + T +Y+ PE V+G E K D+WS+GVI Y L Sbjct: 441 SKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLY 500 Query: 259 GYPPFYSNHGLAISPGMKTRIRMGQYEF-PNPEWSEVSEEVKMLIRNLLKTEPTQRMTIT 317 G PF N T ++ + +F P P V+ E K IR L R+ + Sbjct: 501 GRKPFGHNQSQQDILQENTILKATEVQFPPKP---VVTPEAKAFIRRCLAYRKEDRIDVQ 557 Query: 318 EFMNHPWIM 326 + P+++ Sbjct: 558 QLACDPYLL 566 >3ORP-A nrPDB Length = 311 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 67/224 (29%), Positives = 109/224 (48%), Gaps = 19/224 (8%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-DCPKA-------RREVELHWRAS 112 D Y++ ++LG G +V + R A+K+L+ D + RRE + + A Sbjct: 12 DRYEL-GEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQ-NAAAL 69 Query: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 P IV + D E IVME +DG L + G T + A E++ + Sbjct: 70 NHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEG--PMTPKRAIEVIADACQ 127 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT-SHNSLTTPCY---TPY 228 A+ + H I HRDVKP N++ ++ NA+ K+ DFG A+ S NS+T T Sbjct: 128 ALNFSHQNGIIHRDVKPANIMISAT--NAV-KVMDFGIARAIADSGNSVTQTAAVIGTAQ 184 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAIS 272 Y++PE + D D++SLG ++Y +L G PPF + ++++ Sbjct: 185 YLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVA 228 >3DLS-A nrPDB Length = 335 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 82/278 (29%), Positives = 128/278 (46%), Gaps = 49/278 (17%) Query: 70 LGLGINGKVLQIFNKRTQEKFALK------MLQDC-------PKARREVELHWRASQCPH 116 LG G G V +K ++ +K +L+DC K E+ + R + Sbjct: 32 LGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHA-N 90 Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGG-ELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 I++++D++EN + +VME G +LF+ I DR + E AS I + + A+ Sbjct: 91 IIKVLDIFEN----QGFFQLVMEKHGSGLDLFAFI-DRHPR-LDEPLASYIFRQLVSAVG 144 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL 235 YL +I HRD+K EN++ + +KL DFG A T C T Y APEVL Sbjct: 145 YLRLKDIIHRDIKDENIVIAE---DFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVL 201 Query: 236 ------GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNP 289 GPE +MWSLGV +Y L+ PF + ++ I +P Sbjct: 202 MGNPYRGPE-----LEMWSLGVTLYTLVFEENPF-----CELEETVEAAI--------HP 243 Query: 290 EWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 + VS+E+ L+ LL+ P +R T+ + + PW+ Q Sbjct: 244 PYL-VSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQ 280 >4OW8-A nrPDB Length = 283 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 61/215 (28%), Positives = 102/215 (47%), Gaps = 15/215 (6%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRAS-------QCPHIVRI 120 +++ G G+V + + R + A+K+L+ + E +RA P I + Sbjct: 17 RLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASV 76 Query: 121 VDVYENLYAGR-KCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 D E+ G + +VME ++G L S ++ G + R A ++++ G A+Q H+ Sbjct: 77 HDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDMLEQTGRALQIAHA 134 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY--TPYYVAPEVLGP 237 + HRDVKP N+L T P +K+TDFG AK + T T Y+APE Sbjct: 135 AGLVHRDVKPGNILIT---PTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG 191 Query: 238 EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAIS 272 + D++SLGV+ Y + G PF + L ++ Sbjct: 192 HDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVA 226 >3NIZ-A nrPDB Length = 311 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 71/258 (27%), Positives = 112/258 (43%), Gaps = 52/258 (20%) Query: 101 ARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTE 160 A RE+ L + P+IV ++DV + +CL +V E ++ ++ D + Sbjct: 66 AIREISL-LKELHHPNIVSLIDVIHS----ERCLTLVFEFMEKD--LKKVLDENKTGLQD 118 Query: 161 REASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNS 219 + + + + + H I HRD+KP+NLL S + LKL DFG A+ S Sbjct: 119 SQIKIYLYQLLRGVAHCHQHRILHRDLKPQNLLINS---DGALKLADFGLARAFGIPVRS 175 Query: 220 LTTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTR 278 T T +Y AP+VL G +KY S D+WS+G I ++ G P F PG+ Sbjct: 176 YTHEVVTLWYRAPDVLMGSKKYSTSVDIWSIGCIFAEMITGKPLF---------PGVTDD 226 Query: 279 IRM----GQYEFPNP-EWSEVSE--------------------------EVKMLIRNLLK 307 ++ PNP EW +V E E L+ N+L Sbjct: 227 DQLPKIFSILGTPNPREWPQVQELPLWKQRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLC 286 Query: 308 TEPTQRMTITEFMNHPWI 325 +P +R++ + MNHP+ Sbjct: 287 FDPNKRISARDAMNHPYF 304 >4X3F-A nrPDB Length = 337 Score = 82.4 bits (202), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 61/215 (28%), Positives = 102/215 (47%), Gaps = 15/215 (6%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRAS-------QCPHIVRI 120 +++ G G+V + + R + A+K+L+ + E +RA P I + Sbjct: 18 RLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASV 77 Query: 121 VDVYENLYAGR-KCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 D E+ G + +VME ++G L S ++ G + R A ++++ G A+Q H+ Sbjct: 78 HDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDMLEQTGRALQIAHA 135 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY--TPYYVAPEVLGP 237 + HRDVKP N+L T P +K+TDFG AK + T T Y+APE Sbjct: 136 AGLVHRDVKPGNILIT---PTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG 192 Query: 238 EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAIS 272 + D++SLGV+ Y + G PF + L ++ Sbjct: 193 HDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVA 227 >4CRS-A nrPDB Length = 341 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 80/268 (29%), Positives = 129/268 (48%), Gaps = 26/268 (9%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP-KARREVE---LHWRASQCP 115 + D++ + VL G GKVL K T E FA+K L+ AR EV+ R + Sbjct: 11 LQDFRCCA-VLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETV 69 Query: 116 HIVR---IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 + VR +V+++ + ++ + VME GG+L I F+E A + Sbjct: 70 NSVRHPFLVNLF-ACFQTKEHVCFVMEYAAGGDLMMHIHT---DVFSEPRAVFYAACVVL 125 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TPCYTPYYVA 231 +QYLH I +RD+K +NLL ++ +K+ DFG KE + T T C TP ++A Sbjct: 126 GLQYLHEHKIVYRDLKLDNLLLDTE---GFVKIADFGLCKEGMGYGDRTSTFCGTPEFLA 182 Query: 232 PEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGM-KTRIRMGQYEFPNPE 290 PEVL Y ++ D W LGV++Y +L G PF + + + +R ++ Sbjct: 183 PEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRF------ 236 Query: 291 WSEVSEEVKMLIRNLLKTEPTQRMTITE 318 +S E ++R LL+ P +R+ +E Sbjct: 237 ---LSTEAISIMRRLLRRNPERRLGASE 261 >4TNB-A nrPDB Length = 590 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 73/265 (27%), Positives = 119/265 (44%), Gaps = 32/265 (12%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE---------LHWRASQCPHIV 118 +VLG G G+V + T + +A K L+ +R+ E L SQ +V Sbjct: 190 RVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQ--FVV 247 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 + YE + L +V+ ++GG+L I + G+ F E A I ++ LH Sbjct: 248 NLAYAYET----KDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLH 303 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPE 238 N +RD+KPEN+L ++++D G A + + + T Y+APEVL + Sbjct: 304 HENTVYRDLKPENILLDDY---GHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 Query: 239 KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV---- 294 +Y S D W LG ++Y ++ G PF G K +++ + + E EV Sbjct: 361 RYGLSPDYWGLGCLIYEMIEGQSPF---------RGRKEKVKREEVDRRVLETEEVYSHK 411 Query: 295 -SEEVKMLIRNLLKTEPTQRMTITE 318 SEE K + + LL + QR+ E Sbjct: 412 FSEEAKSICKMLLTKDAKQRLGCQE 436 >4C0T-A nrPDB Length = 974 Score = 81.6 bits (200), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 78/291 (26%), Positives = 134/291 (46%), Gaps = 35/291 (12%) Query: 54 IKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD----CPKARREVELHW 109 I++N + D+K + LG G V+ +K T +++A+K+L K + V + Sbjct: 261 IRRN--VTDFKFGKE-LGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEK 317 Query: 110 RA-SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMK 168 A ++ + + ++ +Y + + L V++ GEL + I+ E Sbjct: 318 HALNRLSNRLGVISLYF-TFQDKDSLYFVLDYASNGELLTLIKRYN--TLNEECTRHFGA 374 Query: 169 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLTTPC-- 224 I +AI+Y+H + HRD+KPEN+L K +++TDFG A+ E + S P Sbjct: 375 QILDAIKYMHDNGVIHRDLKPENILLDDKMR---IQITDFGTARLLEKKNDESEEYPVDV 431 Query: 225 ------YTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPF-YSNHGLAISPGMKT 277 T YV+PE+L + K D+W+ G I+Y ++ G PPF +N L K Sbjct: 432 RAKSFVGTAEYVSPELLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKL 491 Query: 278 RIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328 + FP ++ LI+ +L +P++R TI E H + QS Sbjct: 492 QFAFSA-GFPTI--------IRDLIKKILVLQPSRRATIPEIQKH-YFFQS 532 >4AGU-A nrPDB Length = 311 Score = 81.3 bits (199), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 76/288 (26%), Positives = 130/288 (45%), Gaps = 42/288 (14%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKML---QDCPK----ARREVELHWRASQCPHIVRIVD 122 +G G G V + N+ T + A+K +D P A RE+ + + + P++V +++ Sbjct: 11 IGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRM-LKQLKHPNLVNLLE 69 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182 V+ ++ L +V E D L DR + E I +A+ + H N Sbjct: 70 VFRR----KRRLHLVFEYCDHTVLHE--LDRYQRGVPEHLVKSITWQTLQAVNFCHKHNC 123 Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS-HNSLTTPCYTPYYVAPEVL-GPEKY 240 HRDVKPEN+L T ++++KL DFGFA+ T + T +Y +PE+L G +Y Sbjct: 124 IHRDVKPENILITK---HSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDTQY 180 Query: 241 DKSCDMWSLGVIMYILLCGYPPFYSNHGL-----------AISPGMKTRIRMGQY----E 285 D+W++G + LL G P + + + P + QY + Sbjct: 181 GPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVK 240 Query: 286 FPNPEWSE--------VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 P+PE E +S L++ L +PT+R+T + ++HP+ Sbjct: 241 IPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYF 288 >6B2Q-A nrPDB Length = 317 Score = 80.9 bits (198), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 61/215 (28%), Positives = 102/215 (47%), Gaps = 15/215 (6%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRAS-------QCPHIVRI 120 +++ G G+V + + R + A+K+L+ + E +RA P I + Sbjct: 38 RLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASV 97 Query: 121 VDVYENLYAGR-KCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 D E+ G + +VME ++G L S ++ G + R A ++++ G A+Q H+ Sbjct: 98 HDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDMLEQTGRALQIAHA 155 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY--TPYYVAPEVLGP 237 + HRDVKP N+L T P +K+TDFG AK + T T Y+APE Sbjct: 156 AGLVHRDVKPGNILIT---PTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG 212 Query: 238 EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAIS 272 + D++SLGV+ Y + G PF + L ++ Sbjct: 213 HDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVA 247 >6HXF-B nrPDB Length = 302 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 77/274 (28%), Positives = 132/274 (48%), Gaps = 31/274 (11%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQDCPKARRE---VELHWRAS-QCPHIVRIVDVYE 125 LG G GKV + NK T A K+++ + E VE+ A+ P+IV+++ Y Sbjct: 27 LGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAY- 85 Query: 126 NLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHR 185 + G+ L I++E GG + I D+ TE + + + + EA+ +LHS I HR Sbjct: 86 -YHDGK--LWIMIEFCPGGAV-DAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHR 141 Query: 186 DVKPENLLYTSKRPNAILKLTDFGF-AKETTSHNSLTTPCYTPYYVAPEVLGPEK----- 239 D+K N+L T + ++L DFG AK + + TPY++APEV+ E Sbjct: 142 DLKAGNVLMTLE---GDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTP 198 Query: 240 YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN----PEWSEVS 295 YD D+WSLG+ + + PP + ++P M+ +++ + + P +W S Sbjct: 199 YDYKADIWSLGITLIEMAQIEPPHHE-----LNP-MRVLLKIAKSDPPTLLTPSKW---S 249 Query: 296 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQST 329 E + ++ L P R + + + HP++ T Sbjct: 250 VEFRDFLKIALDKNPETRPSAAQLLEHPFVSSIT 283 >4X7Q-B nrPDB Length = 312 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 77/288 (26%), Positives = 124/288 (43%), Gaps = 41/288 (14%) Query: 69 VLGLGINGKVLQIFNKRTQEKFALKM-----------LQDCPKARREVELHWRASQC--- 114 +LG G G V + + A+K+ L D EV L W+ Sbjct: 38 LLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGH 97 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMEC-LDGGELFSRIQDRGDQAFTEREASEIMKSIGEA 173 P ++R++D +E ++ ++V+E L +LF I ++G E + + A Sbjct: 98 PGVIRLLDWFET----QEGFMLVLERPLPAQDLFDYITEKG--PLGEGPSRCFFGQVVAA 151 Query: 174 IQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPE 233 IQ+ HS + HRD+K EN+L +R A KL DFG + T T Y PE Sbjct: 152 IQHCHSRGVVHRDIKDENILIDLRRGCA--KLIDFG-SGALLHDEPYTDFDGTRVYSPPE 208 Query: 234 VLGPEKYDK-SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWS 292 + +Y +WSLG+++Y ++CG PF + I + FP + Sbjct: 209 WISRHQYHALPATVWSLGILLYDMVCGDIPFERDQ----------EILEAELHFP----A 254 Query: 293 EVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSR 340 VS + LIR L +P+ R ++ E + PW+ T PL+ S+ Sbjct: 255 HVSPDCCALIRRCLAPKPSSRPSLEEILLDPWM--QTPAEDVPLNPSK 300 >4UY9-A nrPDB Length = 323 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 57/199 (28%), Positives = 93/199 (46%), Gaps = 18/199 (9%) Query: 170 IGEAIQYLHS---INIAHRDVKPENLLYTSKRPNA-----ILKLTDFGFAKETTSHNSLT 221 I + YLH + I HRD+K N+L K N ILK+TDFG A+E ++ Sbjct: 116 IARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMS 175 Query: 222 TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRM 281 T ++APEV+ + K D+WS GV+++ LL G PF GLA++ G + M Sbjct: 176 AAG-TYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYG----VAM 230 Query: 282 GQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRV 341 + P P S E L+ + +P R + T ++ ++ + + P + Sbjct: 231 NKLALPIP--STCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHC 288 Query: 342 LKEDKERWEDVKEEMTSAL 360 L+++ W+ +EM L Sbjct: 289 LQDN---WKHEIQEMFDQL 304 >5TQX-A nrPDB Length = 655 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 42/130 (32%), Positives = 63/130 (48%), Gaps = 1/130 (0%) Query: 135 LIVMECLDGGELFSRIQD-RGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL 193 L+ ME GG+L + E + ++ IG I+YLH I HRD+KPEN++ Sbjct: 87 LLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIV 146 Query: 194 YTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIM 253 I K+ D G+AK+ T T Y+APE+ + Y + D WS G ++ Sbjct: 147 LQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAPELFENKPYTATVDYWSFGTMV 206 Query: 254 YILLCGYPPF 263 + + GY PF Sbjct: 207 FECIAGYRPF 216 >5O2C-A nrPDB Length = 380 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 71/276 (25%), Positives = 130/276 (47%), Gaps = 35/276 (12%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQD--CPKA-----RREVELHWRASQCPHIVRIVD 122 LG G V + + T + A LQD KA + E E+ + Q P+IVR D Sbjct: 33 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEM-LKGLQHPNIVRFYD 91 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN- 181 +E++ G+KC+++V E + G L + ++ + + + I + +Q+LH+ Sbjct: 92 SWESILKGKKCIVLVTELMTSGTLKTYLKRF--KVMKPKVLRSWCRQILKGLQFLHTRTP 149 Query: 182 -IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY-TPYYVAPEVLGPEK 239 I HRD+K +N+ T P +K+ D G A T S TP ++APE+ E Sbjct: 150 PIIHRDLKCDNIFITG--PTGSVKIGDLGLA--TLMRTSFAKSVIGTPEFMAPEMY-EEH 204 Query: 240 YDKSCDMWSLGVIMYILLCGYPPFYSNHGLA-----ISPGMKTRIRMGQYEFPNPEWSEV 294 YD+S D+++ G+ M + P+ A ++ G+K +++V Sbjct: 205 YDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKP-----------ASFNKV 253 Query: 295 SE-EVKMLIRNLLKTEPTQRMTITEFMNHPWIMQST 329 ++ EVK +I ++ ++R++I + +NH + + T Sbjct: 254 TDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDT 289 >2XNP-A nrPDB Length = 279 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 78/283 (27%), Positives = 126/283 (44%), Gaps = 31/283 (10%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELH------WRASQC 114 +DY+V + G G G+ +I K + K L E ++ R + Sbjct: 6 EDYEVLYTI-GTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKH 64 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQD--RGDQAFTEREASEIMKSIGE 172 P+IVR D + L IVME +GG+L S I + Q E +M + Sbjct: 65 PNIVRYYD--RIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTL 122 Query: 173 AIQYLH-----SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TPCYT 226 A++ H + HRD+KP N+ K+ +KL DFG A+ S T T Sbjct: 123 ALKECHRRSDGGHTVLHRDLKPANVFLDGKQN---VKLGDFGLARILNHDTSFAKTFVGT 179 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPF--YSNHGLAISPGMKTRIRMGQY 284 PYY++PE + Y++ D+WSLG ++Y L PPF +S LA +IR G++ Sbjct: 180 PYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELA------GKIREGKF 233 Query: 285 EFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 + S+E+ +I +L + R ++ E + +P I++ Sbjct: 234 RRIPYRY---SDELNEIITRMLNLKDYHRPSVEEILENPLILE 273 >4AU8-A nrPDB Length = 296 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 85/293 (29%), Positives = 127/293 (43%), Gaps = 53/293 (18%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKML------QDCPK-ARREVELHWRASQCPHIVRIVD 122 +G G G V + N+ T E ALK + + P A RE+ L + + +IVR+ D Sbjct: 14 IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICL-LKELKHKNIVRLHD 72 Query: 123 VYENLYAGRKCLLIVMEC-LDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN 181 V L++ +K L+ C D + F D + +++K +G + HS N Sbjct: 73 V---LHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLG----FCHSRN 125 Query: 182 IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY-----TPYYVAPEVL- 235 + HRD+KP+NLL N LKL DFG A+ + CY T +Y P+VL Sbjct: 126 VLHRDLKPQNLLINR---NGELKLADFGLARAF----GIPVRCYSAEVVTLWYRPPDVLF 178 Query: 236 GPEKYDKSCDMWSLGVIMYILL-CGYPPFYSNH------------GLAISPGMKTRIRMG 282 G + Y S DMWS G I L G P F N G + ++ Sbjct: 179 GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLP 238 Query: 283 QYEFPNPEWSEVSEEVKM----------LIRNLLKTEPTQRMTITEFMNHPWI 325 Y+ P P + + V + L++NLLK P QR++ E + HP+ Sbjct: 239 DYK-PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 290 >3DAK-A nrPDB Length = 290 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 77/292 (26%), Positives = 133/292 (45%), Gaps = 36/292 (12%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM--LQDCPKARREVELHWRA-SQCPHI 117 DDY++ +V+G G V + +EK A+K L+ C + E+ +A SQC H Sbjct: 10 DDYEL-QEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHH- 67 Query: 118 VRIVDVYENLYAGRKCLLIVMECLDGG---ELFSRIQDRGDQ---AFTEREASEIMKSIG 171 IV Y + + + L +VM+ L GG ++ I +G+ E + I++ + Sbjct: 68 PNIVSYYTS-FVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVL 126 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT------TPCY 225 E ++YLH HRDVK N+L + +++ DFG + + +T T Sbjct: 127 EGLEYLHKNGQIHRDVKAGNILLGE---DGSVQIADFGVSAFLATGGDITRNKVRKTFVG 183 Query: 226 TPYYVAPEVLGPEK-YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQY 284 TP ++APEV+ + YD D+WS G+ L G P++ P MK + Q Sbjct: 184 TPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHK------YPPMKVLMLTLQN 237 Query: 285 EFPNPEWSEVSEEV--------KMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328 + P+ E +E+ + +I L+ +P +R T E + H + ++ Sbjct: 238 DPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKA 289 >5X8I-B nrPDB Length = 346 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 84/317 (26%), Positives = 137/317 (43%), Gaps = 67/317 (21%) Query: 70 LGLGINGKVLQ-IFNKRTQEKFALKMLQD----CPKARREVEL--HWRASQCPHIVRIVD 122 LG G GKV++ I +K A+K++++ C AR E+++ H + R V Sbjct: 21 LGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQ 80 Query: 123 VYENL-YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN 181 + E + G C IV E L G + I++ G F ++ I +++ +LHS Sbjct: 81 MLEWFEHHGHIC--IVFELL-GLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNK 137 Query: 182 IAHRDVKPENLLYTS-----------KRP-----NAILKLTDFGFAKETTSHNSLTTPCY 225 + H D+KPEN+L+ KR N +K+ DFG A H+S T Sbjct: 138 LTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHS--TLVS 195 Query: 226 TPYYVAPEVLGPEKYDKSCDMWSLGVIM---YILLCGYPPFYSNHGLAISPGM------- 275 T +Y APEV+ + + CD+WS+G I+ Y+ +P S LA+ + Sbjct: 196 TRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKH 255 Query: 276 ---KTRIRMGQYEFPNPEWSEVS------------------------EEVKMLIRNLLKT 308 KTR R + +W E S E + LI+ +L+ Sbjct: 256 MIQKTRKR-KYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDLIQKMLEY 314 Query: 309 EPTQRMTITEFMNHPWI 325 +P +R+T+ E + HP+ Sbjct: 315 DPAKRITLREALKHPFF 331 >4OTD-A nrPDB Length = 341 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 80/281 (28%), Positives = 133/281 (47%), Gaps = 33/281 (11%) Query: 51 GLQIKKNAI-IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP-KARREVE-- 106 G ++K+ + ++D+K + VLG G GKVL + + E FA+K L+ AR EVE Sbjct: 1 GSMLRKSPLTLEDFKFLA-VLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESL 59 Query: 107 -------LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFT 159 ++ P +V + ++ + + VME GG+L I F+ Sbjct: 60 MCEKRILAAVTSAGHPFLVNLFGCFQT----PEHVCFVMEYSAGGDLMLHIHS---DVFS 112 Query: 160 EREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS 219 E A + +Q+LH I +RD+K +NLL ++ +K+ DFG KE + Sbjct: 113 EPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTE---GYVKIADFGLCKEGMGYGD 169 Query: 220 LT-TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGM-KT 277 T T C TP ++APEVL Y ++ D W LGV++Y +L G PF + + + Sbjct: 170 RTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVND 229 Query: 278 RIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITE 318 +R ++ +S E ++R LL+ P +R+ +E Sbjct: 230 EVRYPRF---------LSAEAIGIMRRLLRRNPERRLGSSE 261 >4E7W-A nrPDB Length = 394 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 79/283 (27%), Positives = 128/283 (45%), Gaps = 28/283 (9%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI-VDVYEN 126 +V+G G G V Q + E K+LQD RE+++ R + P++V + Y N Sbjct: 46 KVIGNGSFGVVFQAKLVESDEVAIKKVLQDKRFKNRELQI-MRIVKHPNVVDLKAFFYSN 104 Query: 127 LYAGRKCLL-IVMECL-DGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 184 + L +V+E + + SR + Q M + ++ Y+HSI I H Sbjct: 105 GDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAYIHSIGICH 164 Query: 185 RDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPE-VLGPEKYDKS 243 RD+KP+NLL P+ +LKL DFG AK + + + YY APE + G Y + Sbjct: 165 RDIKPQNLLLDP--PSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPELIFGATNYTTN 222 Query: 244 CDMWSLGVIMYILLCGYPPFYSNHGL--------AISPGMKTRIRM-----GQYEFPNPE 290 D+WS G +M L+ G P F G+ + + +I+ +++FP Sbjct: 223 IDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNYMEHKFPQIR 282 Query: 291 ---WSEVSE-----EVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 +S+V + LI LL+ P+ R+T E + HP+ Sbjct: 283 PHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFF 325 >4QTB-A nrPDB Length = 380 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 77/299 (25%), Positives = 133/299 (44%), Gaps = 51/299 (17%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQ------DCPKARREVELHWRASQCPHIVRIV 121 Q +G G G V ++ + + A+K + C + RE+++ R +++ I Sbjct: 47 QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH-ENVIGIR 105 Query: 122 DVY--ENLYAGRKCLLI--VMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL 177 D+ L A R ++ +ME +L+ ++ Q + + I ++Y+ Sbjct: 106 DILRASTLEAMRDVYIVQDLMET----DLYKLLKS---QQLSNDHICYFLYQILRGLKYI 158 Query: 178 HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK----ETTSHNSLTTPCYTPYYVAPE 233 HS N+ HRD+KP NLL + LK+ DFG A+ E LT T +Y APE Sbjct: 159 HSANVLHRDLKPSNLLINT---TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 215 Query: 234 V-LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH---------GLAISPG-------MK 276 + L + Y KS D+WS+G I+ +L P F H G+ SP + Sbjct: 216 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 275 Query: 277 TRIRMGQYEFPNP---EWSEV-----SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 + R P+ W+++ S+ + +L R +L P +R+T+ E + HP++ Q Sbjct: 276 MKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDR-MLTFNPNKRITVEEALAHPYLEQ 333 >6FYV-A nrPDB Length = 337 Score = 78.2 bits (191), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 84/316 (26%), Positives = 136/316 (43%), Gaps = 65/316 (20%) Query: 70 LGLGINGKVLQIFNKRTQE-KFALKMLQDCPK----ARREVEL--HWRASQCPHIVRIVD 122 LG G GKV++ + A+K++++ + AR E+++ H ++ + R V Sbjct: 22 LGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQ 81 Query: 123 VYENL-YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN 181 + E + G C IV E L G + I++ F ++ I ++I +LH Sbjct: 82 MLEWFDHHGHVC--IVFELL-GLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNK 138 Query: 182 IAHRDVKPENLL---------YTSKRP-------NAILKLTDFGFAKETTSHNSLTTPCY 225 + H D+KPEN+L Y SK N +K+ DFG A H+S T Sbjct: 139 LTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHS--TLVS 196 Query: 226 TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFY---SNHGLA--------ISPG 274 T +Y APEV+ + + CD+WS+G I+ G+ F S LA I Sbjct: 197 TRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQH 256 Query: 275 MKTRIRMGQYEFPNP-EWSEVS------------------------EEVKMLIRNLLKTE 309 M + R +Y N +W E S E++ L+R +L+ + Sbjct: 257 MIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYD 316 Query: 310 PTQRMTITEFMNHPWI 325 PTQR+T+ E + HP+ Sbjct: 317 PTQRITLDEALQHPFF 332 >2W96-B nrPDB Length = 306 Score = 78.2 bits (191), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 62/208 (29%), Positives = 96/208 (46%), Gaps = 16/208 (7%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR--------REVELHWR--ASQCPHIVR 119 +G+G G V + + + ALK ++ P REV L R A + P++VR Sbjct: 12 IGVGAYGTVYKARDPHSGHFVALKSVR-VPNGEEGLPISTVREVALLRRLEAFEHPNVVR 70 Query: 120 IVDVYENLYAGRKC-LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 ++DV R+ + +V E +D +L + + ++M+ + +LH Sbjct: 71 LMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLH 129 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPE 238 + I HRD+KPEN+L TS +KL DFG A+ + +L T +Y APEVL Sbjct: 130 ANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEVLLQS 186 Query: 239 KYDKSCDMWSLGVIMYILLCGYPPFYSN 266 Y DMWS+G I + P F N Sbjct: 187 TYATPVDMWSVGCIFAEMFRRKPLFCGN 214 >5O2B-A nrPDB Length = 285 Score = 77.8 bits (190), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 71/276 (25%), Positives = 130/276 (47%), Gaps = 35/276 (12%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQD--CPKA-----RREVELHWRASQCPHIVRIVD 122 LG G V + + T + A LQD KA + E E+ + Q P+IVR D Sbjct: 24 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEM-LKGLQHPNIVRFYD 82 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN- 181 +E++ G+KC+++V E + G L + ++ + + + I + +Q+LH+ Sbjct: 83 SWESILKGKKCIVLVTELMTSGTLKTYLKRF--KVMKPKVLRSWCRQILKGLQFLHTRTP 140 Query: 182 -IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY-TPYYVAPEVLGPEK 239 I HRD+K +N+ T P +K+ D G A T S TP ++APE+ E Sbjct: 141 PIIHRDLKCDNIFITG--PTGSVKIGDLGLA--TLMRTSFAKSVIGTPEFMAPEMY-EEH 195 Query: 240 YDKSCDMWSLGVIMYILLCGYPPFYSNHGLA-----ISPGMKTRIRMGQYEFPNPEWSEV 294 YD+S D+++ G+ M + P+ A ++ G+K +++V Sbjct: 196 YDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKP-----------ASFNKV 244 Query: 295 SE-EVKMLIRNLLKTEPTQRMTITEFMNHPWIMQST 329 ++ EVK +I ++ ++R++I + +NH + + T Sbjct: 245 TDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDT 280 >5D7A-A nrPDB Length = 308 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 56/198 (28%), Positives = 91/198 (45%), Gaps = 15/198 (7%) Query: 134 LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL 193 L +VME G + I++ E + I + I + +LH + HRD+K +N+L Sbjct: 95 LWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVL 154 Query: 194 YTSKRPNAILKLTDFGF-AKETTSHNSLTTPCYTPYYVAPEVLGPEK-----YDKSCDMW 247 T NA +KL DFG A+ + T TPY++APEV+ ++ YD D+W Sbjct: 155 LTE---NAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLW 211 Query: 248 SLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLK 307 SLG+ + G PP H M+ + + P + + S++ + I + L Sbjct: 212 SLGITAIEMAEGAPPLCDMH------PMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLV 265 Query: 308 TEPTQRMTITEFMNHPWI 325 +QR + M HP+I Sbjct: 266 KNHSQRPATEQLMKHPFI 283 >3NYO-A nrPDB Length = 576 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 55/210 (26%), Positives = 91/210 (43%), Gaps = 12/210 (5%) Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 R V Y + L +V+ ++GG+L I G F E A I ++ LH Sbjct: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPE 238 I +RD+KPEN+L + ++++D G A ++ T Y+APEV+ E Sbjct: 304 RERIVYRDLKPENILLDD---HGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE 360 Query: 239 KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEV 298 +Y S D W+LG ++Y ++ G PF ++ ++ E P S + Sbjct: 361 RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVK----EVPEEYSERFSPQA 416 Query: 299 KMLIRNLLKTEPTQRM-----TITEFMNHP 323 + L LL +P +R+ + E HP Sbjct: 417 RSLCSQLLCKDPAERLGCRGGSAREVKEHP 446 >3DTC-A nrPDB Length = 271 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 52/162 (32%), Positives = 77/162 (47%), Gaps = 17/162 (10%) Query: 170 IGEAIQYLHS---INIAHRDVKPENLLYTSKRPNA-----ILKLTDFGFAKETTSHNSLT 221 I + YLH + I HRD+K N+L K N ILK+TDFG A+E H + Sbjct: 114 IARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREW--HRTTK 171 Query: 222 TPCYTPY-YVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIR 280 Y ++APEV+ + K D+WS GV+++ LL G PF GLA++ G + Sbjct: 172 MSAAGAYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYG----VA 227 Query: 281 MGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNH 322 M + P P S E L+ + +P R + T ++ Sbjct: 228 MNKLALPIP--STCPEPFAKLMEDCWNPDPHSRPSFTNILDQ 267 >5UNP-A nrPDB Length = 369 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 89/359 (24%), Positives = 156/359 (43%), Gaps = 83/359 (23%) Query: 46 FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQ-IFNKRTQEKFALKMLQDCPK---- 100 +HV LQ + Y++ S LG G G+V+Q + ++R + ALK++++ K Sbjct: 26 YHVGDWLQ-------ERYEIVS-TLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEA 77 Query: 101 ARREVELHWRASQ--------CPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQD 152 AR E+ + + ++ C V++ D ++ Y G C I E L G F ++D Sbjct: 78 ARLEINVLEKINEKDPDNKNLC---VQMFDWFD--YHGHMC--ISFELL-GLSTFDFLKD 129 Query: 153 RGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTS-----------KRP-- 199 + + + + +A+++LH + H D+KPEN+L+ + KR Sbjct: 130 NNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDER 189 Query: 200 ---NAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYIL 256 + +++ DFG A T H +T T +Y APEV+ + + CD+WS+G I++ Sbjct: 190 SVKSTAVRVVDFGSA--TFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEY 247 Query: 257 LCGYPPFYSNHG---LA--------ISPGMKTRIRMGQYEFPNP-EWSE-------VSEE 297 G+ F ++ LA I M + R +Y + +W E V E Sbjct: 248 YVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVREN 307 Query: 298 VK-----------------MLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTS 339 K LI ++L+ EP +R+T+ E + HP+ + P L S Sbjct: 308 CKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDS 366 >4FR4-A nrPDB Length = 384 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 73/270 (27%), Positives = 130/270 (48%), Gaps = 27/270 (10%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWRASQCPHIVR---IVD 122 + +G G GKV + T++ +A+K + Q C + R EV ++ Q + +V+ Sbjct: 21 RAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVE-RNEVRNVFKELQIMQGLEHPFLVN 79 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182 ++ + + + + +V++ L GG+L +Q + F E + + A+ YL + I Sbjct: 80 LWYS-FQDEEDMFMVVDLLLGGDLRYHLQQ--NVHFKEETVKLFICELVMALDYLQNQRI 136 Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEK--- 239 HRD+KP+N+L + + +TDF A +TT T Y+APE+ K Sbjct: 137 IHRDMKPDNILLDE---HGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKGAG 193 Query: 240 YDKSCDMWSLGVIMYILLCGYPPFY---SNHGLAISPGMKTRIRMGQYEFPNPEWSEVSE 296 Y + D WSLGV Y LL G P++ S I +T + +P+ W S+ Sbjct: 194 YSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTV----VTYPSA-W---SQ 245 Query: 297 EVKMLIRNLLKTEPTQRMT-ITEFMNHPWI 325 E+ L++ LL+ P QR + +++ N P++ Sbjct: 246 EMVSLLKKLLEPNPDQRFSQLSDVQNFPYM 275 >3C51-A nrPDB Length = 543 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 53/188 (28%), Positives = 93/188 (49%), Gaps = 10/188 (5%) Query: 134 LLIVMECLDGGELFSRIQ--DRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPEN 191 L +VM ++GG++ I D + F E A I +++LH NI +RD+KPEN Sbjct: 260 LCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNIIYRDLKPEN 319 Query: 192 LLYTSKRPNAILKLTDFGFAKETTSHNSLTTP-CYTPYYVAPEVLGPEKYDKSCDMWSLG 250 +L + ++++D G A E + + T TP ++APE+L E+YD S D ++LG Sbjct: 320 VLLDD---DGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEYDFSVDYFALG 376 Query: 251 VIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEP 310 V +Y ++ PF + + +K R+ +P+ + S K LL+ +P Sbjct: 377 VTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPD----KFSPASKDFCEALLQKDP 432 Query: 311 TQRMTITE 318 +R+ + Sbjct: 433 EKRLGFRD 440 >6CQF-A nrPDB Length = 297 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 74/270 (27%), Positives = 119/270 (44%), Gaps = 24/270 (8%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQ-----DCPKARREVELHWRASQCPHIVRIVD 122 Q LG G G+V + +K + + ALKM++ D ++E+ + C H IV Sbjct: 22 QRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILI---LKTCRH-ANIV- 76 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182 Y Y + L I ME G L Q G + +E + S + + + + + YLHS Sbjct: 77 AYHGSYLWLQKLWICMEFCGAGSLQDIYQVTG--SLSELQISYVCREVLQGLAYLHSQKK 134 Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY-TPYYVAPEVLG---PE 238 HRD+K N+L ++L DFG + + + + TPY++APEV Sbjct: 135 IHRDIKGANILINDAGE---VRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALKG 191 Query: 239 KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN-PEWSEVSEE 297 Y++ CD+WSLG+ L PP + H L + M Y+ P E + S Sbjct: 192 GYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKS----GYQPPRLKEKGKWSAA 247 Query: 298 VKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 I+ L P +R + T+ ++H + Q Sbjct: 248 FHNFIKVTLTKSPKKRPSATKMLSHQLVSQ 277 >4MYG-A nrPDB Length = 372 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 58/204 (28%), Positives = 100/204 (49%), Gaps = 21/204 (10%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQD-------CPKARREVELHWRASQCPHIVRIVD 122 +G G G V +KR+ EK A+K L +A RE+ L + Q +++ ++D Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYREL-LLLKHMQHENVIGLLD 109 Query: 123 VYENLYAGRKC--LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 V+ + R +VM + + +Q F+E + ++ + + ++Y+HS Sbjct: 110 VFTPASSLRNFYDFYLVMPFMQ-----TDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSA 164 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV-LGPEK 239 + HRD+KP NL + + LK+ DFG A+ + +T T +Y APEV L Sbjct: 165 GVVHRDLKPGNL---AVNEDCELKILDFGLARHADA--EMTGYVVTRWYRAPEVILSWMH 219 Query: 240 YDKSCDMWSLGVIMYILLCGYPPF 263 Y+++ D+WS+G IM +L G F Sbjct: 220 YNQTVDIWSVGCIMAEMLTGKTLF 243 >3ZDU-A nrPDB Length = 325 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 60/200 (30%), Positives = 99/200 (49%), Gaps = 18/200 (9%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQDCPK------ARREVELHWRASQCPHIVRIVDV 123 +G G G V++ +K T + A+K+ + P+ A RE++ + ++V +++V Sbjct: 11 VGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKF-LKQFHHENLVNLIEV 69 Query: 124 YENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIA 183 + +K + +V E +D L +Q + + + I AI YLHS NI Sbjct: 70 FRQ----KKKIHLVFEFIDHTVL-DELQHYC-HGLESKRLRKYLFQILRAIDYLHSNNII 123 Query: 184 HRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL-TTPCYTPYYVAPE-VLGPEKYD 241 HRD+KPEN+L + + I KL DFGFA+ + + T +Y APE VL Y Sbjct: 124 HRDIKPENILVSQ---SGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTSYG 180 Query: 242 KSCDMWSLGVIMYILLCGYP 261 K D+W+LG ++ + G P Sbjct: 181 KPVDIWALGCMIIEMATGNP 200 >5EFQ-A nrPDB Length = 347 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 64/226 (28%), Positives = 101/226 (44%), Gaps = 21/226 (9%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-DCPK------ARREVEL----- 107 +D + + ++G G G+V + +K T E ALK ++ D K A RE+++ Sbjct: 10 VDKFDIIG-IIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLT 68 Query: 108 HWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIM 167 H IV + + + +V E +D + + G F E M Sbjct: 69 HQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHD--LMGLLESGLVHFNENHIKSFM 126 Query: 168 KSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--LTTPCY 225 + + E + Y H N HRD+K N+L ++ +KL DFG A+ +S S T Sbjct: 127 RQLMEGLDYCHKKNFLHRDIKCSNILLNNR---GQIKLADFGLARLYSSEESRPYTNKVI 183 Query: 226 TPYYVAPE-VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLA 270 T +Y PE +LG E+Y + D+WS G I+ L P F +N LA Sbjct: 184 TLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELA 229 >3E7O-A nrPDB Length = 360 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 79/300 (26%), Positives = 132/300 (44%), Gaps = 54/300 (18%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRIVD 122 +G G G V F+ A+K L +A RE+ L + +I+ +++ Sbjct: 30 IGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVL-LKCVNHKNIISLLN 88 Query: 123 VY--ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 V+ + + + +VME +D L I D ER S ++ + I++LHS Sbjct: 89 VFTPQKTLEEFQDVYLVMELMDAN-LCQVIHMELDH---ER-MSYLLYQMLCGIKHLHSA 143 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTP-CYTPYYVAPEVLGPEK 239 I HRD+KP N++ S + LK+ DFG A+ T S N + TP T YY APEV+ Sbjct: 144 GIIHRDLKPSNIVVKS---DCTLKILDFGLAR-TASTNFMMTPYVVTRYYRAPEVILGMG 199 Query: 240 YDKSCDMWSLGVIMYILLCGYPPFYSNHGL-------------------AISPGMKTRIR 280 Y ++ D+WS+G IM L+ G F + A+ P ++ + Sbjct: 200 YKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTVRNYVE 259 Query: 281 MG------QYEFPNPEWSEVSE---------EVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 +E P+W SE + + L+ +L +P +R+++ E + HP+I Sbjct: 260 NRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI 319 >4PWN-A nrPDB Length = 274 Score = 75.1 bits (183), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 56/225 (24%), Positives = 104/225 (46%), Gaps = 22/225 (9%) Query: 110 RASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 169 + Q P+IVR D +E+ G+KC+++V E + G L + ++ + + + Sbjct: 64 KGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRF--KVMKIKVLRSWCRQ 121 Query: 170 IGEAIQYLHSIN--IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTP 227 I + +Q+LH+ I HRD+K +N+ T P +K+ D G A + + TP Sbjct: 122 ILKGLQFLHTRTPPIIHRDLKCDNIFITG--PTGSVKIGDLGLATLEKRASFAKSVIGTP 179 Query: 228 YYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLA-----ISPGMKTRIRMG 282 ++APE+ EKYD+S D+++ G+ M + P+ A ++ G+K Sbjct: 180 EFMAPEMY-EEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVK------ 232 Query: 283 QYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 P EVK +I ++ +R +I + +NH + + Sbjct: 233 ----PASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >2WTK-C nrPDB Length = 305 Score = 75.1 bits (183), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 72/281 (25%), Positives = 130/281 (46%), Gaps = 41/281 (14%) Query: 65 VTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC---------PKARREVELHWRASQCP 115 + +LG G GKV ++ + T + A+K+L+ ++E++L R Sbjct: 8 LMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRH-K 66 Query: 116 HIVRIVDVYENLYAGRKCLLIVME-CLDG-GELFSRIQDRGDQAFTEREASEIMKSIGEA 173 +++++VDV N ++ + +VME C+ G E+ + ++ F +A + + Sbjct: 67 NVIQLVDVLYN--EEKQKMYMVMEYCVCGMQEMLDSVPEK---RFPVCQAHGYFCQLIDG 121 Query: 174 IQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFG-------FAKETTSHNSLTTPCYT 226 ++YLHS I H+D+KP NLL T+ LK++ G FA + T S +P + Sbjct: 122 LEYLHSQGIVHKDIKPGNLLLTT---GGTLKISALGVAEALHPFAADDTCRTSQGSPAFQ 178 Query: 227 PYYVAPEVL-GPEKYDK-SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQY 284 P PE+ G + + D+WS GV +Y + G PF ++ + I G Y Sbjct: 179 P----PEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLF----ENIGKGSY 230 Query: 285 EFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 P +S+ L++ +L+ EP +R +I + H W Sbjct: 231 AIPGDCGPPLSD----LLKGMLEYEPAKRFSIRQIRQHSWF 267 >4NST-A nrPDB Length = 351 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 65/226 (28%), Positives = 101/226 (44%), Gaps = 21/226 (9%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-DCPK------ARREVEL----- 107 +D + + ++G G G+V + +K T E ALK ++ D K A RE+++ Sbjct: 12 VDKFDIIG-IIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLI 70 Query: 108 HWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIM 167 H IV + + +V E +D + + G F+E M Sbjct: 71 HRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHD--LMGLLESGLVHFSEDHIKSFM 128 Query: 168 KSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--LTTPCY 225 K + E ++Y H N HRD+K N+L + + +KL DFG A+ S S T Sbjct: 129 KQLMEGLEYCHKKNFLHRDIKCSNILLNN---SGQIKLADFGLARLYNSEESRPYTNKVI 185 Query: 226 TPYYVAPE-VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLA 270 T +Y PE +LG E+Y + D+WS G I+ L P F +N LA Sbjct: 186 TLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELA 231 >1ZXE-A nrPDB Length = 303 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 63/217 (29%), Positives = 98/217 (45%), Gaps = 38/217 (17%) Query: 131 RKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPE 190 + L I ME + L+ I E + + I EA+ Y+HS I HR++KP Sbjct: 87 KSTLFIQMEYCENRTLYDLIHSENLNQ-QRDEYWRLFRQILEALSYIHSQGIIHRNLKPM 145 Query: 191 NLLYTSKRPNAILKLTDFGFAKET---------------TSHNSLTTPCYTPYYVAPEVL 235 N+ R +K+ DFG AK S ++LT+ T YVA EVL Sbjct: 146 NIFIDESRN---VKIGDFGLAKNVHRSLDILKLDSQNLPGSSDNLTSAIGTAMYVATEVL 202 Query: 236 -GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMK-----TRIRMGQYEFPNP 289 G Y++ DM+SLG+I + ++ YP S GM+ ++R EFP P Sbjct: 203 DGTGHYNEKIDMYSLGIIFFEMI--YP---------FSTGMERVNILKKLRSVSIEFP-P 250 Query: 290 EWSEVSEEV-KMLIRNLLKTEPTQRMTITEFMNHPWI 325 ++ + +V K +IR L+ +P +R +N W+ Sbjct: 251 DFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGWL 287 >1G3N-A nrPDB Length = 326 Score = 74.3 bits (181), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 61/205 (29%), Positives = 100/205 (48%), Gaps = 15/205 (7%) Query: 70 LGLGINGKVLQIFNKRTQEKF-ALKML------QDCPKAR-REVEL--HWRASQCPHIVR 119 +G G GKV + + + +F ALK + + P + REV + H + P++VR Sbjct: 19 IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVR 78 Query: 120 IVDVYENLYAGRKC-LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 + DV R+ L +V E +D +L + + + ++M + + +LH Sbjct: 79 LFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLH 137 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPE 238 S + HRD+KP+N+L TS + +KL DFG A+ + +LT+ T +Y APEVL Sbjct: 138 SHRVVHRDLKPQNILVTS---SGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQS 194 Query: 239 KYDKSCDMWSLGVIMYILLCGYPPF 263 Y D+WS+G I + P F Sbjct: 195 SYATPVDLWSVGCIFAEMFRRKPLF 219 >2I6L-A nrPDB Length = 320 Score = 74.3 bits (181), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 62/223 (27%), Positives = 97/223 (43%), Gaps = 33/223 (14%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKML-----QDCPKARREVELHWRASQCPHIVRIVDVY 124 LG G NG V + ++ A+K + Q A RE+++ R IV V+ Sbjct: 19 LGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHD----NIVKVF 74 Query: 125 ENL-------------YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 E L + IV E ++ + + ++G E A M + Sbjct: 75 EILGPSGSQLTDDVGSLTELNSVYIVQEYMETD--LANVLEQG--PLLEEHARLFMYQLL 130 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS----LTTPCYTP 227 ++Y+HS N+ HRD+KP NL ++ + +LK+ DFG A+ H S L+ T Sbjct: 131 RGLKYIHSANVLHRDLKPANLFINTE--DLVLKIGDFGLARIMDPHYSHKGHLSEGLVTK 188 Query: 228 YYVAPE-VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL 269 +Y +P +L P Y K+ DMW+ G I +L G F H L Sbjct: 189 WYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHEL 231 >4LQP-A nrPDB Length = 508 Score = 73.9 bits (180), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 85/333 (25%), Positives = 132/333 (39%), Gaps = 87/333 (26%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRA-------SQCPHIV 118 T +V+G G G+V + K T + +A+K L +++ H +A S P +V Sbjct: 106 TVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSPWVV 165 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 + +++ + L ++ME L GG+L + + Q FTE M AI+ +H Sbjct: 166 SLYYSFQDA----QYLYLIMEFLPGGDLMTMLIRW--QLFTEDVTRFYMAECILAIETIH 219 Query: 179 SINIAHRDVKPEN-------------------------------LLYTSKRPNAILK--- 204 + HR +KP+N LL + N I K Sbjct: 220 KLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGISKPGT 279 Query: 205 ----LTDFGFAKETTSHNSLT---------------------TPCYTPYYVAPEVLGPEK 239 TD ++T +S++ + TP Y+APE+ + Sbjct: 280 YNANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYIAPEIFLYQG 339 Query: 240 YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMG---QYEFPNPEWSEVSE 296 Y + CD WSLG IMY L G+PPF S +P R M +FP+ +S Sbjct: 340 YGQECDWWSLGAIMYECLIGWPPFCSE-----TPQETYRKIMNFEQTLQFPDD--IHISY 392 Query: 297 EVKMLIRNLLKTEPTQRM----TITEFMNHPWI 325 E + LIR LL T QR+ E +HP+ Sbjct: 393 EAEDLIRRLL-THADQRLGRHGGADEIKSHPFF 424 >5DBX-A nrPDB Length = 328 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 76/284 (26%), Positives = 127/284 (44%), Gaps = 36/284 (12%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM--LQDCPKARREVELHWRA-SQCPHI 117 D Y++ +V+G G V K QE+ A+K L+ C + E+ +A SQC H Sbjct: 11 DAYEL-QEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSH- 68 Query: 118 VRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQ---DRGDQ---AFTEREASEIMKSIG 171 +V Y + + + L +VM+ L GG + I+ +RG+ E + I+K + Sbjct: 69 PNVVTYYTS-FVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVL 127 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTP------CY 225 E + YLH HRD+K N+L + +++ DFG + + +T Sbjct: 128 EGLDYLHRNGQIHRDLKAGNILLGE---DGSVQIADFGVSAFLATGGDVTRNKVRKDFVG 184 Query: 226 TPYYVAPEVLGPEK-YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQY 284 TP ++APEV+ + YD DMWS G+ L G P++ P MK + Q Sbjct: 185 TPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHK------YPPMKVLMLTLQN 238 Query: 285 EFPNPEWSEVSEEV--------KMLIRNLLKTEPTQRMTITEFM 320 + P E +E+ + L+ L+ +P++R T E + Sbjct: 239 DPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELL 282 >5Y86-A nrPDB Length = 588 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 50/203 (24%), Positives = 99/203 (48%), Gaps = 13/203 (6%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARRE------VELHWRASQCPHIVRIV 121 +++G G G+V ++++ + ++ ALKM+++ + R+ + H + + ++ Sbjct: 213 KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVI 272 Query: 122 DVYENL-YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 + E+ + C+ + +D L+ I+ Q F+ + + +SI +++ LH Sbjct: 273 HMLESFTFRNHVCMAFELLSID---LYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKN 329 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY 240 I H D+KPEN+L ++ K+ DFG + L T + +Y APE++ +Y Sbjct: 330 KIIHCDLKPENILLKHHGRSST-KVIDFG--SSCFEYQKLYTYIQSRFYRAPEIILGSRY 386 Query: 241 DKSCDMWSLGVIMYILLCGYPPF 263 D+WS G I+ LL G P F Sbjct: 387 STPIDIWSFGCILAELLTGQPLF 409 >1U5R-A nrPDB Length = 348 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 58/208 (27%), Positives = 91/208 (43%), Gaps = 19/208 (9%) Query: 124 YENLYAGRKCLLIVME-CLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182 Y Y +VME CL S + + + E E + + + + YLHS N+ Sbjct: 119 YRGCYLREHTAWLVMEYCLGSA---SDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNM 175 Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV---LGPEK 239 HRDVK N+L + ++KL DFG A NS TPY++APEV + + Sbjct: 176 IHRDVKAGNILLSEP---GLVKLGDFGSASIMAPANSFVG---TPYWMAPEVILAMDEGQ 229 Query: 240 YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVK 299 YD D+WSLG+ L PP ++ + M + Q E P + SE + Sbjct: 230 YDGKVDVWSLGITCIELAERKPPLFNMN------AMSALYHIAQNESPALQSGHWSEYFR 283 Query: 300 MLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 + + L+ P R T + H ++++ Sbjct: 284 NFVDSCLQKIPQDRPTSEVLLKHRFVLR 311 >5AWM-A nrPDB Length = 394 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 74/301 (24%), Positives = 125/301 (41%), Gaps = 55/301 (18%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRIVD 122 +G G G V ++ TQ+ A+K L +A RE +L + +I+ +++ Sbjct: 52 IGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKL-MKLVNHKNIIGLLN 110 Query: 123 VY---ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 + NL + L VME +D L IQ D S ++ + I++LHS Sbjct: 111 AFTPQRNLEEFQDVYL-VMELMDAN-LCQVIQMDLDHD----RMSYLLYQMLCGIKHLHS 164 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEK 239 I HRD+KP N++ + + LK+ DFG A+ + +T T YY APEV+ Sbjct: 165 AGIIHRDLKPSNIVV---KADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMG 221 Query: 240 YDKSCDMWSLGVIMYILLCG-----------------------YPPFYSNHGLAISPGMK 276 Y ++ D+WS+G IM ++ G P F + ++ Sbjct: 222 YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVE 281 Query: 277 TRIRMGQYEFP------------NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPW 324 R R Y F N + + + L+ +L +P QR+++ E + H + Sbjct: 282 NRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEY 341 Query: 325 I 325 I Sbjct: 342 I 342 >2GCD-A nrPDB Length = 309 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 58/208 (27%), Positives = 91/208 (43%), Gaps = 19/208 (9%) Query: 124 YENLYAGRKCLLIVME-CLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182 Y Y +VME CL S + + + E E + + + + YLHS N+ Sbjct: 80 YRGCYLREHTAWLVMEYCLGSA---SDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNM 136 Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV---LGPEK 239 HRDVK N+L + ++KL DFG A NS TPY++APEV + + Sbjct: 137 IHRDVKAGNILLSEP---GLVKLGDFGSASIMAPANSFVG---TPYWMAPEVILAMDEGQ 190 Query: 240 YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVK 299 YD D+WSLG+ L PP ++ + M + Q E P + SE + Sbjct: 191 YDGKVDVWSLGITCIELAERKPPLFNMN------AMSALYHIAQNESPALQSGHWSEYFR 244 Query: 300 MLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 + + L+ P R T + H ++++ Sbjct: 245 NFVDSCLQKIPQDRPTSEVLLKHRFVLR 272 >3UIU-A nrPDB Length = 306 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 53/191 (27%), Positives = 85/191 (44%), Gaps = 19/191 (9%) Query: 132 KCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPEN 191 KCL I ME D G L I+ R + + A E+ + I + + Y+HS + HRD+KP N Sbjct: 107 KCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSN 166 Query: 192 LLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV 251 + + +K+ DFG + T T Y++PE + + Y K D+++LG+ Sbjct: 167 IFLVDTKQ---VKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGL 223 Query: 252 IMYILL--CGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTE 309 I+ LL C S + G+ + I F E K L++ LL + Sbjct: 224 ILAELLHVCDTAFETSKFFTDLRDGIISDI------FDKKE--------KTLLQKLLSKK 269 Query: 310 PTQRMTITEFM 320 P R +E + Sbjct: 270 PEDRPNTSEIL 280 >4LFI-A nrPDB Length = 374 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 55/200 (27%), Positives = 87/200 (43%), Gaps = 37/200 (18%) Query: 159 TEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN 218 T+ E M + +A+ Y HS+ I HRDVKP N++ K N L+L D+G A+ + Sbjct: 170 TDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK--NKKLRLIDWGLAEFYHVNM 227 Query: 219 SLTTPCYTPYYVAPEVLGPEK-YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISP---- 273 + ++ PE+L + YD S D+WS G ++ ++ PF+ HG + + Sbjct: 228 EYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFF--HGTSNTDQLVK 285 Query: 274 --------------------------GMKTRIRMGQYEFPNPEWSEVS--EEVKMLIRNL 305 M IR + F N +S +E+ LI NL Sbjct: 286 IVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNL 345 Query: 306 LKTEPTQRMTITEFMNHPWI 325 L+ + +R+T E M HPW Sbjct: 346 LRYDHQERLTAKEAMGHPWF 365 >3ALO-A nrPDB Length = 327 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 68/292 (23%), Positives = 128/292 (43%), Gaps = 29/292 (9%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQDCPKARR------EVELHWRASQCPHIVRIVDV 123 +G G G V ++ +K + + A+K ++ + ++++ R+S CP+IV+ Sbjct: 30 IGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQF--- 86 Query: 124 YENLYAGRKCLLIVMECLDGG--ELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL-HSI 180 Y L+ C I ME + + + + D E +I + +A+ +L ++ Sbjct: 87 YGALFREGDCW-ICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENL 145 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGP--- 237 I HRD+KP N+L + +KL DFG + + + T Y+APE + P Sbjct: 146 KIIHRDIKPSNILLDR---SGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSAS 202 Query: 238 -EKYDKSCDMWSLGVIMYILLCG---YPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSE 293 + YD D+WSLG+ +Y L G YP + S + + ++ + N E E Sbjct: 203 RQGYDVRSDVWSLGITLYELATGRFPYPKWNS-----VFDQLTQVVKGDPPQLSNSEERE 257 Query: 294 VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI-MQSTKVPQTPLHTSRVLKE 344 S + L + ++R E + HP+I M + + + ++L + Sbjct: 258 FSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQ 309 >6O6Q-A nrPDB Length = 335 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 72/290 (24%), Positives = 125/290 (43%), Gaps = 45/290 (15%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQDCP--KARREVELHWRASQCPHIVRIVDVYENL 127 LG G +V + +EK +K+L+ K +RE+ + P+I+ ++DV Sbjct: 49 LGRGKYSEVFLGIDLEKREKVVIKVLKPVKRKKIKREISILKNLVDGPNIIAMLDVVRE- 107 Query: 128 YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDV 187 K ++ E ++ + S FT+ + M + +A+ Y HS+ I HRDV Sbjct: 108 -PQSKTPGLIFEHINNIDFRSLYP-----TFTDYDIRFYMYELLKALDYSHSMGIMHRDV 161 Query: 188 KPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEK-YDKSCDM 246 KP N++ + +L+L D+G A+ + Y+ PE+L + YD S DM Sbjct: 162 KPHNVMIDHDKK--LLRLIDWGLAEYYHPGTEYNVRVASRYFKGPELLVDYRLYDYSLDM 219 Query: 247 WSLGVIMYILLCGYPPFYSNHGLAISPGM-----------------KTRIRMG-QYE--- 285 WS G ++ ++ PF+ HG + + + K I +G +YE Sbjct: 220 WSFGCMLASMVFMKEPFF--HGKSNTDQLVQIVRVLGSKNFKKYLEKYNISLGEEYEDIG 277 Query: 286 -FPNPEWSE---------VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 + +W VS+E LI LL+ + +R+T E M H + Sbjct: 278 YYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKHAYF 327 >3E3P-A nrPDB Length = 360 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 60/210 (28%), Positives = 94/210 (44%), Gaps = 30/210 (14%) Query: 165 EIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPC 224 ++++SIG +L S+N+ HRD+KP N+L + LKL DFG AK+ + Sbjct: 137 QLIRSIG--CLHLPSVNVCHRDIKPHNVLVNE--ADGTLKLCDFGSAKKLSPSEPNVAYI 192 Query: 225 YTPYYVAPE-VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSN------HGLAISPGMKT 277 + YY APE + G + Y + D+WS+G I ++ G P F + H + G + Sbjct: 193 CSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPS 252 Query: 278 R----------IRMGQYEFPNPEWSEV--------SEEVKMLIRNLLKTEPTQRMTITEF 319 R + Y WS V ++E L+ LL+ P +RM E Sbjct: 253 REVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKPYEA 312 Query: 320 MNHPWIMQSTKVPQTPLHTSRVLKEDKERW 349 + HP+ P T L ++ L ED R+ Sbjct: 313 LCHPY-FDELHDPATKLPNNKDLPEDLFRF 341 >4EWQ-A nrPDB Length = 383 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 58/205 (28%), Positives = 100/205 (48%), Gaps = 22/205 (10%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRIVD 122 +G G G V F+ +T + A+K L + RE+ L + + +++ ++D Sbjct: 53 VGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRL-LKHMKHENVIGLLD 111 Query: 123 VY---ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 V+ +L L+ L G +L + ++ Q T+ ++ I ++Y+HS Sbjct: 112 VFTPARSLEEFNDVYLVTH--LMGADLNNIVKC---QKLTDDHVQFLIYQILRGLKYIHS 166 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV-LGPE 238 +I HRD+KP NL + + LK+ DFG A+ T + +T T +Y APE+ L Sbjct: 167 ADIIHRDLKPSNL---AVNEDCELKILDFGLARHTD--DEMTGYVATRWYRAPEIMLNWM 221 Query: 239 KYDKSCDMWSLGVIMYILLCGYPPF 263 Y+++ D+WS+G IM LL G F Sbjct: 222 HYNQTVDIWSVGCIMAELLTGRTLF 246 >6GVJ-A nrPDB Length = 429 Score = 72.0 bits (175), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 75/295 (25%), Positives = 128/295 (43%), Gaps = 52/295 (17%) Query: 63 YKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQCP 115 Y + Q+ G G + KV Q+ N++ Q +A+K + Q R E+ + Q Sbjct: 146 YSILKQI-GSGGSSKVFQVLNEKKQ-IYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQ-- 201 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 H +I+ +Y+ + + +VMEC G + + ++ E K++ EA+ Sbjct: 202 HSDKIIRLYD-YEITDQYIYMVMEC---GNIDLNSWLKKKKSIDPWERKSYWKNMLEAVH 257 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE---TTSHNSLTTPCYTPYYVAP 232 +H I H D+KP N L + +LKL DFG A + T+ + T Y+ P Sbjct: 258 TIHQHGIVHSDLKPANFLIV----DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPP 313 Query: 233 EVLGPEKYDKS-----------CDMWSLGVIMYILLCGYPPF------YSNHGLAISPGM 275 E + + D+WSLG I+Y + G PF S I P Sbjct: 314 EAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNH 373 Query: 276 KTRIRMGQYEFPN-PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQST 329 + EFP+ PE ++++ +++ LK +P QR++I E + HP++ T Sbjct: 374 EI-------EFPDIPE-----KDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQT 416 >2XS0-A nrPDB Length = 386 Score = 71.2 bits (173), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 77/303 (25%), Positives = 129/303 (42%), Gaps = 60/303 (19%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRIVD 122 +G G G V ++ + A+K L +A RE+ L +C + I+ Sbjct: 34 IGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVL----MKCVNHKNIIG 89 Query: 123 VYENLYAGRKCL------LIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 + N++ +K L IVME +D L IQ D ER S ++ + I++ Sbjct: 90 LL-NVFTPQKSLEEFQDVYIVMELMDAN-LCQVIQMELDH---ER-MSYLLYQMLCGIKH 143 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 236 LHS I HRD+KP N++ S + LK+ DFG A+ + + T YY APEV+ Sbjct: 144 LHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMVPFVVTRYYRAPEVIL 200 Query: 237 PEKYDKSCDMWSLGVIMYILLCG-----------------------YPPFYSNHGLAISP 273 Y ++ D+WS+G IM ++ G P F + Sbjct: 201 GMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRT 260 Query: 274 GMKTRIRMGQYE----FPNPEWSEVSEEVKM-------LIRNLLKTEPTQRMTITEFMNH 322 ++ R + Y FP+ + SE K+ L+ +L + ++R+++ E + H Sbjct: 261 YVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQH 320 Query: 323 PWI 325 P+I Sbjct: 321 PYI 323 >4IAN-A nrPDB Length = 358 Score = 71.2 bits (173), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 39/110 (35%), Positives = 60/110 (54%), Gaps = 6/110 (5%) Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAP 232 A++ L NI H D+KP+N+L + ILKL DFG A N +T + +Y AP Sbjct: 147 ALKLLKRCNILHADIKPDNILVNESK--TILKLCDFGSASHVAD-NDITPYLVSRFYRAP 203 Query: 233 EVLGPEKYDKSCDMWSLGVIMYILLCG---YPPFYSNHGLAISPGMKTRI 279 E++ + YD DMWS+G +Y L G +P +NH L ++ +K ++ Sbjct: 204 EIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKM 253 >4EUT-A nrPDB Length = 396 Score = 71.2 bits (173), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 98/213 (46%), Gaps = 19/213 (8%) Query: 67 SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR------REVELHWRASQCPHIVRI 120 S +LG G V + +K+T + FA+K+ + R RE E+ + + +IV++ Sbjct: 14 SDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH-KNIVKL 72 Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQ-AFTEREASEIMKSIGEAIQYLHS 179 + E K L +ME G L++ +++ + E E +++ + + +L Sbjct: 73 FAIEEETTTRHKVL--IMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 130 Query: 180 INIAHRDVKPENLL-YTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL--- 235 I HR++KP N++ + ++ KLTDFG A+E + T Y+ P++ Sbjct: 131 NGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERA 190 Query: 236 -----GPEKYDKSCDMWSLGVIMYILLCGYPPF 263 +KY + D+WS+GV Y G PF Sbjct: 191 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 223 >4QNY-A nrPDB Length = 354 Score = 70.9 bits (172), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 52/200 (26%), Positives = 83/200 (41%), Gaps = 28/200 (14%) Query: 153 RGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK 212 R Q TE + A+ +HS + HRD+ P N+L + N LK+ DFG AK Sbjct: 117 RSGQELTEAHIQFFIYQALRALHIIHSAGVIHRDITPANILVNT---NCDLKICDFGLAK 173 Query: 213 ETTSHNSLTTPCYT-PYYVAPEVLGPEK-YDKSCDMWSLGVIMYILLCGYPPFYSNHGL- 269 E T T +Y APE++ +K Y D+W +G I+ LL P F + Sbjct: 174 EENDQGEYMTDYVTMRWYRAPELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVN 233 Query: 270 ------------------AISPGMKTRIRMGQYEFPNPEWSE----VSEEVKMLIRNLLK 307 ++ + + P +W + S E L+R++L Sbjct: 234 QLDKIVDVIGTPSEEDINSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLV 293 Query: 308 TEPTQRMTITEFMNHPWIMQ 327 P +R+T+ + M HP++ Q Sbjct: 294 FNPKRRITVLQAMRHPFLEQ 313 >4PDO-A nrPDB Length = 299 Score = 70.9 bits (172), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 62/231 (26%), Positives = 116/231 (50%), Gaps = 27/231 (11%) Query: 65 VTSQ-VLGLGINGKVLQIFNKRTQEK----FALKMLQDCPKARREVELHWRAS---QCPH 116 VT Q V+G G G+V + K + K A+K L+ ++ V+ A Q H Sbjct: 36 VTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSH 95 Query: 117 --IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 I+R+ E + + K ++I+ E ++ G L ++++ D F+ + +++ I + Sbjct: 96 HNIIRL----EGVISKYKPMMIITEYMENGALDKFLREK-DGEFSVLQLVGMLRGIAAGM 150 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCYTP--YYV 230 +YL ++N HRD+ N+L S N + K++DFG ++ E + TT + Sbjct: 151 KYLANMNYVHRDLAARNILVNS---NLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWT 207 Query: 231 APEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPFY--SNHGL--AISPGMK 276 APE + K+ + D+WS G++M+ ++ G P++ SNH + AI+ G + Sbjct: 208 APEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFR 258 >5NGU-A nrPDB Length = 381 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 68/292 (23%), Positives = 125/292 (42%), Gaps = 41/292 (14%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQ------DCPKARREVELHWRASQCPHIVRIVDV 123 +G G G V ++ + + A+K + C + RE+++ R +I+ I D+ Sbjct: 50 IGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRH-ENIIGINDI 108 Query: 124 YENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIA 183 + + +++ L +L+ ++ Q + + I ++Y+HS N+ Sbjct: 109 IRAPTIEQMKDVYIVQDLMETDLYKLLKT---QHLSNDHICYFLYQILRGLKYIHSANVL 165 Query: 184 HRDVKPENLLYTSKRPNAILKLTDFGFAK----ETTSHNSLTTPCYTPYYVAPEV-LGPE 238 HRD+KP NLL + LK+ DFG A+ + LT T +Y APE+ L + Sbjct: 166 HRDLKPSNLLLNT---TCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSK 222 Query: 239 KYDKSCDMWSLGVIMYILLCGYPPFYSNH---------GLAISPGMK-----TRIRMGQY 284 Y KS D+WS+G I+ +L P F H G+ SP + ++ Y Sbjct: 223 GYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNY 282 Query: 285 EFPNPEWSEV---------SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 P ++V + L+ +L P +R+ + + + HP++ Q Sbjct: 283 LLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQ 334 >2A1A-B nrPDB Length = 284 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 39/126 (30%), Positives = 64/126 (50%), Gaps = 3/126 (2%) Query: 132 KCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPEN 191 KCL I ME D G L I+ R + + A E+ + I + + Y+HS + +RD+KP N Sbjct: 93 KCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLINRDLKPSN 152 Query: 192 LLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV 251 + + +K+ DFG + T T Y++PE + + Y K D+++LG+ Sbjct: 153 IFLVDTKQ---VKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGL 209 Query: 252 IMYILL 257 I+ LL Sbjct: 210 ILAELL 215 >4BBM-A nrPDB Length = 331 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 62/209 (29%), Positives = 104/209 (49%), Gaps = 29/209 (13%) Query: 69 VLGLGINGKVLQIFNKRTQEKFALKMLQDCPK-------ARREVELHWRASQCPHIVRIV 121 ++G G G V++ NK T A+K + A RE++L + + ++V ++ Sbjct: 32 LVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKL-LKQLRHENLVNLL 90 Query: 122 DVYENLYAGRKCLLIVME-----CLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 +V + +K +V E LD ELF + D ++ +I+ IG + Sbjct: 91 EVCKK----KKRWYLVFEFVDHTILDDLELFP---NGLDYQVVQKYLFQIINGIG----F 139 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL-TTPCYTPYYVAPEVL 235 HS NI HRD+KPEN+L + + ++KL DFGFA+ + + T +Y APE+L Sbjct: 140 CHSHNIIHRDIKPENILVSQ---SGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELL 196 Query: 236 -GPEKYDKSCDMWSLGVIMYILLCGYPPF 263 G KY K+ D+W++G ++ + G P F Sbjct: 197 VGDVKYGKAVDVWAIGCLVTEMFMGEPLF 225 >3OZ6-A nrPDB Length = 388 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 71/256 (27%), Positives = 113/256 (44%), Gaps = 54/256 (21%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQCPHIVRIVD 122 LG G G V + ++RT E A+K + D + RE+ + S +IV +++ Sbjct: 17 LGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSGHENIVNLLN 76 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182 V + + +V + ++ +L + I+ ++ + + I+YLHS + Sbjct: 77 VLR--ADNDRDVYLVFDYMET-DLHAVIRA---NILEPVHKQYVVYQLIKVIKYLHSGGL 130 Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAK-----------------ETTSHNSLTTPCY 225 HRD+KP N+L ++ +K+ DFG ++ E T + P Sbjct: 131 LHRDMKPSNILLNAE---CHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQPIL 187 Query: 226 TPY-----YVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKT-- 277 T Y Y APE+L G KY K DMWSLG I+ +LCG P F PG T Sbjct: 188 TDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIF---------PGSSTMN 238 Query: 278 ---RIRMGQYEFPNPE 290 RI +G +FP+ E Sbjct: 239 QLERI-IGVIDFPSNE 253 >4EUU-A nrPDB Length = 319 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 98/213 (46%), Gaps = 19/213 (8%) Query: 67 SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR------REVELHWRASQCPHIVRI 120 S +LG G V + +K+T + FA+K+ + R RE E+ + + +IV++ Sbjct: 14 SDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH-KNIVKL 72 Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQ-AFTEREASEIMKSIGEAIQYLHS 179 + E K L +ME G L++ +++ + E E +++ + + +L Sbjct: 73 FAIEEETTTRHKVL--IMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 130 Query: 180 INIAHRDVKPENLL-YTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL--- 235 I HR++KP N++ + ++ KLTDFG A+E + T Y+ P++ Sbjct: 131 NGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERA 190 Query: 236 -----GPEKYDKSCDMWSLGVIMYILLCGYPPF 263 +KY + D+WS+GV Y G PF Sbjct: 191 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 223 >3GC9-A nrPDB Length = 370 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 56/205 (27%), Positives = 105/205 (51%), Gaps = 22/205 (10%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKML----QDCPKARR---EVELHWRASQCPHIVRIVD 122 +G G G V ++ R ++K A+K L Q ARR E+ L + + +++ ++D Sbjct: 36 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRL-LKHLKHENVIGLLD 94 Query: 123 VYE---NLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 V+ ++ + L+ L G +L + ++ QA ++ ++ + ++Y+HS Sbjct: 95 VFTPATSIEDFSEVYLVT--TLMGADLNNIVKS---QALSDEHVQFLVYQLLRGLKYIHS 149 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV-LGPE 238 I HRD+KP N+ + ++ L++ DFG A++ + +T T +Y APE+ L Sbjct: 150 AGIIHRDLKPSNV---AVNEDSELRILDFGLARQ--ADEEMTGYVATRWYRAPEIMLNWM 204 Query: 239 KYDKSCDMWSLGVIMYILLCGYPPF 263 Y+++ D+WS+G IM LL G F Sbjct: 205 HYNQTVDIWSVGCIMAELLQGKALF 229 >6NT9-A nrPDB Length = 742 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 98/213 (46%), Gaps = 19/213 (8%) Query: 67 SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR------REVELHWRASQCPHIVRI 120 S +LG G V + +K+T + FA+K+ + R RE E+ + + +IV++ Sbjct: 12 SDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH-KNIVKL 70 Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQ-AFTEREASEIMKSIGEAIQYLHS 179 + E K L +ME G L++ +++ + E E +++ + + +L Sbjct: 71 FAIEEETTTRHKVL--IMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 128 Query: 180 INIAHRDVKPENLL-YTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL--- 235 I HR++KP N++ + ++ KLTDFG A+E + T Y+ P++ Sbjct: 129 NGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERA 188 Query: 236 -----GPEKYDKSCDMWSLGVIMYILLCGYPPF 263 +KY + D+WS+GV Y G PF Sbjct: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 >4UYA-A nrPDB Length = 340 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 40/114 (35%), Positives = 59/114 (51%), Gaps = 9/114 (7%) Query: 170 IGEAIQYLHS---INIAHRDVKPENLLYTSKRP-----NAILKLTDFGFAKETTSHNSLT 221 I + YLH + I HRD+K N+L K N LK+TDFG A+E + Sbjct: 133 IARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMA 192 Query: 222 TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGM 275 T + +APEV+ + K D+WS GV+++ LL G P+ GLA++ G+ Sbjct: 193 TAGAYAW-MAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGV 245 >1JNK-A nrPDB Length = 423 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 75/299 (25%), Positives = 128/299 (42%), Gaps = 52/299 (17%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRIVD 122 +G G G V ++ A+K L +A RE+ L + +I+ +++ Sbjct: 70 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL-MKCVNHKNIISLLN 128 Query: 123 VY--ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 V+ + + + +VME +D L IQ D ER S ++ + I++LHS Sbjct: 129 VFTPQKTLEEFQDVYLVMELMDAN-LCQVIQMELDH---ER-MSYLLYQMLCGIKHLHSA 183 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY 240 I HRD+KP N++ S + LK+ DFG A+ + +T T YY APEV+ Y Sbjct: 184 GIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 240 Query: 241 DKSCDMWSLGVIM------YILLCGY-----------------PPFYSNHGLAISPGMKT 277 ++ D+WS+G IM IL G P F + ++ Sbjct: 241 KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN 300 Query: 278 RIRMGQYEFPN-------PEWSE----VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 R + FP P SE + + + L+ +L +P +R+++ + + HP+I Sbjct: 301 RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 359 >3RAW-A nrPDB Length = 381 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 74/317 (23%), Positives = 130/317 (41%), Gaps = 67/317 (21%) Query: 70 LGLGINGKVLQIFNK-RTQEKFALKMLQDCPKARREVELHW--------RASQCPHIVRI 120 LG G GKV++ + R + + ALK++++ K R L + + + + Sbjct: 59 LGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVL 118 Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 + + N + G C I E L G F +++ Q + + + A+++LH Sbjct: 119 MSDWFNFH-GHMC--IAFELL-GKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHEN 174 Query: 181 NIAHRDVKPENLLYTSKR----------------PNAILKLTDFGFAKETTSHNSLTTPC 224 + H D+KPEN+L+ + N +++ DFG A T H TT Sbjct: 175 QLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSA--TFDHEHHTTIV 232 Query: 225 YTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLA-----------ISP 273 T +Y PEV+ + + CD+WS+G I++ G+ F ++ I Sbjct: 233 ATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPS 292 Query: 274 GMKTRIRMGQYEFPNP-EWSEVS----------------------EEVKM--LIRNLLKT 308 M R R +Y + W E S E V++ L+R +L+ Sbjct: 293 HMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEF 352 Query: 309 EPTQRMTITEFMNHPWI 325 +P QR+T+ E + HP+ Sbjct: 353 DPAQRITLAEALLHPFF 369 >3HMP-A nrPDB Length = 342 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 77/296 (26%), Positives = 128/296 (43%), Gaps = 54/296 (18%) Query: 63 YKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVE-LHWRASQC 114 Y + Q+ G G + KV Q+ N++ Q +A+K + Q R E+ L+ Sbjct: 58 YSILKQI-GSGGSSKVFQVLNEKKQ-IYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHS 115 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 I+R+ D YE + + +VMEC G + + ++ E K++ EA+ Sbjct: 116 DKIIRLYD-YE---ITDQYIYMVMEC---GNIDLNSWLKKKKSIDPWERKSYWKNMLEAV 168 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE---TTSHNSLTTPCYTPYYVA 231 +H I H D+KP N L + +LKL DFG A + T+ + T Y+ Sbjct: 169 HTIHQHGIVHSDLKPANFLIV----DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMP 224 Query: 232 PEVLGPEKYDKS-----------CDMWSLGVIMYILLCGYPPF------YSNHGLAISPG 274 PE + + D+WSLG I+Y + G PF S I P Sbjct: 225 PEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPN 284 Query: 275 MKTRIRMGQYEFPN-PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQST 329 + EFP+ PE ++++ +++ LK +P QR++I E + HP++ T Sbjct: 285 H-------EIEFPDIPE-----KDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQT 328 >4TPT-A nrPDB Length = 303 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 57/216 (26%), Positives = 102/216 (47%), Gaps = 38/216 (17%) Query: 65 VTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELH----WRASQCPHIVRI 120 + +VLG G G+ +++ +K T + +K L C + ++ L R+ P++++ Sbjct: 3 IHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKF 62 Query: 121 VDVYENLYAGRKCLLIVMECLDGGEL--FSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 + V LY +K L ++ E ++GG L F R D F ++ K I + YLH Sbjct: 63 IGV---LYKDKK-LNLLTEYIEGGTLKDFLRSMD----PFPWQQKVRFAKGIASGMAYLH 114 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFA-------------KETTSHNSLT---- 221 S+ I HRD+ N L + + + + DFG + K TT +L Sbjct: 115 SMCIIHRDLNSHNCLI---KLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDR 171 Query: 222 ----TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIM 253 T PY++APE+L + YD++ D++S G+++ Sbjct: 172 KKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVL 207 >3N9X-A nrPDB Length = 432 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 93/394 (23%), Positives = 156/394 (39%), Gaps = 105/394 (26%) Query: 56 KNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM-------LQDCPKARREVELH 108 KN + D + ++G G G V ++K T++ A+K L DC + RE+ + Sbjct: 20 KNVHVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITIL 79 Query: 109 WRASQCPHIVRIVDVY--ENLYAGRKCLLIVMECLDGG--ELFSRIQDRGDQAFTEREAS 164 R + +I+R+ D+ ++L + L IV+E D +LF + TE Sbjct: 80 NRL-KSDYIIRLYDLIIPDDLLKFDE-LYIVLEIADSDLKKLF-----KTPIFLTEEHIK 132 Query: 165 EIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS-------- 216 I+ ++ ++H I HRD+KP N L + +K+ DFG A+ S Sbjct: 133 TILYNLLLGENFIHESGIIHRDLKPANCLLNQ---DCSVKVCDFGLARTINSEKDTNIVN 189 Query: 217 ----------HNS-----LTTPCYTPYYVAPE-VLGPEKYDKSCDMWSLGVIMYILL--- 257 HN LT+ T +Y APE +L E Y KS D+WS G I LL Sbjct: 190 DLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNML 249 Query: 258 --------CGYPPFYSNHGLAISPGMKTR------------------------------- 278 +P F + +SP ++ Sbjct: 250 QSHINDPTNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINK 309 Query: 279 ------IRMGQYEFP---NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ-- 327 I++ + P ++ +S++ L+ ++LK P +R+TI + ++HP++ Sbjct: 310 PEVIKYIKLFPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLKDVR 369 Query: 328 -------STKVPQTPLHTSRVLKEDKERWEDVKE 354 STK P VL E + R+ +KE Sbjct: 370 KKKLENFSTKKIILPFDDWMVLSETQLRYIFLKE 403 >3FI2-A nrPDB Length = 353 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 57/193 (29%), Positives = 93/193 (48%), Gaps = 18/193 (9%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRIVD 122 +G G G V ++ A+K L +A RE+ L + +I+ +++ Sbjct: 32 IGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVL-MKCVNHKNIISLLN 90 Query: 123 VY--ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 V+ + + + +VME +D L IQ D ER S ++ + I++LHS Sbjct: 91 VFTPQKTLEEFQDVYLVMELMDAN-LCQVIQMELDH---ER-MSYLLYQMLCGIKHLHSA 145 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY 240 I HRD+KP N++ S + LK+ DFG A+ + +T T YY APEV+ Y Sbjct: 146 GIIHRDLKPSNIVVKS---DCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY 202 Query: 241 DKSCDMWSLGVIM 253 ++ D+WS+G IM Sbjct: 203 KENVDIWSVGCIM 215 >2ZMD-A nrPDB Length = 390 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 80/311 (25%), Positives = 135/311 (43%), Gaps = 55/311 (17%) Query: 63 YKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVE-LHWRASQC 114 Y + Q+ G G + KV Q+ N++ Q +A+K + Q R E+ L+ Sbjct: 58 YSILKQI-GSGGSSKVFQVLNEKKQ-IYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHS 115 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 I+R+ D YE + + +VMEC G + + ++ E K++ EA+ Sbjct: 116 DKIIRLYD-YE---ITDQYIYMVMEC---GNIDLNSWLKKKKSIDPWERKSYWKNMLEAV 168 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE---TTSHNSLTTPCYTPYYVA 231 +H I H D+KP N L + +LKL DFG A + T+ + Y+ Sbjct: 169 HTIHQHGIVHSDLKPANFLIV----DGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMP 224 Query: 232 PEVLGPEKYDKS-----------CDMWSLGVIMYILLCGYPPF------YSNHGLAISPG 274 PE + + D+WSLG I+Y + G PF S I P Sbjct: 225 PEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPN 284 Query: 275 MKTRIRMGQYEFPN-PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI-MQSTKVP 332 + EFP+ PE ++++ +++ LK +P QR++I E + HP++ +Q+ V Sbjct: 285 H-------EIEFPDIPE-----KDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVN 332 Query: 333 QTPLHTSRVLK 343 Q T+ +K Sbjct: 333 QMAKGTTEEMK 343 >4JLC-A nrPDB Length = 657 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 97/213 (45%), Gaps = 19/213 (8%) Query: 67 SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR------REVELHWRASQCPHIVRI 120 S +LG G V + +K+T + +A+K+ + R RE E+ + + +IV++ Sbjct: 13 SDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNH-KNIVKL 71 Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQD-RGDQAFTEREASEIMKSIGEAIQYLHS 179 + E K L +ME G L++ +++ E E +++ + + +L Sbjct: 72 FAIEEETTTRHKVL--IMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 129 Query: 180 INIAHRDVKPENLL-YTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL--- 235 I HRD+KP N++ + ++ KLTDFG A+E + T Y+ P++ Sbjct: 130 NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERA 189 Query: 236 -----GPEKYDKSCDMWSLGVIMYILLCGYPPF 263 +KY + D+WS+GV Y G PF Sbjct: 190 VLRKDHQKKYGATVDLWSVGVTFYHAATGSLPF 222 >5HVK-A nrPDB Length = 315 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 53/208 (25%), Positives = 98/208 (47%), Gaps = 27/208 (12%) Query: 65 VTSQVLGLGINGKVLQIFNKRTQEKFALK-MLQDCPKARREVELHWRASQC---PHIVRI 120 + +VLG G G+ +++ ++ T E +K +++ + +R + +C P++++ Sbjct: 17 IHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKF 76 Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 + V LY ++ L + E + GG L I+ D + + K I + YLHS+ Sbjct: 77 IGV---LYKDKR-LNFITEYIKGGTLRGIIKSM-DSQYPWSQRVSFAKDIASGMAYLHSM 131 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAK----ETTSHNSLT-----------TPCY 225 NI HR++ N L R N + + DFG A+ E T L T Sbjct: 132 NIIHRNLNSHNCLV---RENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVG 188 Query: 226 TPYYVAPEVLGPEKYDKSCDMWSLGVIM 253 PY++APE++ YD+ D++S G+++ Sbjct: 189 NPYWMAPEMINGRSYDEKVDVFSFGIVL 216 >1UA2-A nrPDB Length = 346 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 55/163 (33%), Positives = 78/163 (47%), Gaps = 12/163 (7%) Query: 101 ARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTE 160 A RE++L S P+I+ ++D + G K + ++ +L I+D T Sbjct: 59 ALREIKLLQELSH-PNIIGLLDAF-----GHKSNISLVFDFMETDLEVIIKDN-SLVLTP 111 Query: 161 REASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN-S 219 M + ++YLH I HRD+KP NLL N +LKL DFG AK S N + Sbjct: 112 SHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDE---NGVLKLADFGLAKSFGSPNRA 168 Query: 220 LTTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYP 261 T T +Y APE+L G Y DMW++G I+ LL P Sbjct: 169 YTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVP 211 >1CM8-A nrPDB Length = 367 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 84/330 (25%), Positives = 142/330 (43%), Gaps = 57/330 (17%) Query: 33 AQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFAL 92 + PPP + Q K+ +++ A+ D Q +G G G V + RT K A+ Sbjct: 2 SSPPPARSGFYRQEVTKTAWEVR--AVYRDL----QPVGSGAYGAVCSAVDGRTGAKVAI 55 Query: 93 KMLQD-------CPKARREVEL--HWRASQCPHIVRIVDVY---ENLYAGRKCLLIV-ME 139 K L +A RE+ L H R +++ ++DV+ E L L++ Sbjct: 56 KKLYRPFQSELFAKRAYRELRLLKHMRHE---NVIGLLDVFTPDETLDDFTDFYLVMPFM 112 Query: 140 CLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRP 199 D G+L + E ++ + + ++Y+H+ I HRD+KP NL + Sbjct: 113 GTDLGKLMKH------EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNL---AVNE 163 Query: 200 NAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV-LGPEKYDKSCDMWSLGVIMYILLC 258 + LK+ DFG A++ S +T T +Y APEV L +Y ++ D+WS+G IM ++ Sbjct: 164 DCELKILDFGLARQADSE--MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT 221 Query: 259 GYPPFY-SNHGLAISPGMKT----------RIRM--------GQYEFPNPEWSEVSEEVK 299 G F S+H + MK R++ G E +++ + Sbjct: 222 GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNAS 281 Query: 300 MLIRNLLKT----EPTQRMTITEFMNHPWI 325 L NLL+ + QR+T E + HP+ Sbjct: 282 PLAVNLLEKMLVLDAEQRVTAGEALAHPYF 311 >5AP3-A nrPDB Length = 313 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 77/296 (26%), Positives = 128/296 (43%), Gaps = 54/296 (18%) Query: 63 YKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVE-LHWRASQC 114 Y + Q+ G G + KV Q+ N++ Q +A+K + Q R E+ L+ Sbjct: 30 YSILKQI-GSGGSSKVFQVLNEKKQ-IYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHS 87 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 I+R+ D YE + + +VMEC G + + ++ E K++ EA+ Sbjct: 88 DKIIRLYD-YE---ITDQYIYMVMEC---GNIDLNGWLKKKKSIDPWERKSYWKNMLEAV 140 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE---TTSHNSLTTPCYTPYYVA 231 +H I H D+KP N L + +LKL DFG A + T+ + T Y+ Sbjct: 141 HTIHQHGIVHSDLKPANFLIV----DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMP 196 Query: 232 PEVLGPEKYDKS-----------CDMWSLGVIMYILLCGYPPF------YSNHGLAISPG 274 PE + + D+WSLG I+Y + G PF S I P Sbjct: 197 PEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPN 256 Query: 275 MKTRIRMGQYEFPN-PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQST 329 + EFP+ PE ++++ +++ LK +P QR++I E + HP++ T Sbjct: 257 HEI-------EFPDIPE-----KDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQT 300 >6O8B-A nrPDB Length = 665 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 97/213 (45%), Gaps = 19/213 (8%) Query: 67 SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR------REVELHWRASQCPHIVRI 120 S +LG G V + +K+T + FA+K+ + R RE E+ + + +IV++ Sbjct: 20 SDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH-KNIVKL 78 Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQ-AFTEREASEIMKSIGEAIQYLHS 179 + E K L +ME G L++ +++ + E E +++ + + +L Sbjct: 79 FAIEEETTTRHKVL--IMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRE 136 Query: 180 INIAHRDVKPENLL-YTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL--- 235 I HR++KP N++ + ++ KLTDFG A+E T Y+ P++ Sbjct: 137 NGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYERA 196 Query: 236 -----GPEKYDKSCDMWSLGVIMYILLCGYPPF 263 +KY + D+WS+GV Y G PF Sbjct: 197 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 229 >4U41-A nrPDB Length = 332 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 55/212 (25%), Positives = 96/212 (45%), Gaps = 15/212 (7%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENL 127 +V+G G G+V + + +T + A+K++ E++L + R + Y Sbjct: 30 EVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGA 89 Query: 128 YAGRK------CLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN 181 + + L +VME G + +++ E + I + I + +LH + Sbjct: 90 FIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHH 149 Query: 182 IAHRDVKPENLLYTSKRPNAILKLTDFGF-AKETTSHNSLTTPCYTPYYVAPEVLGPEK- 239 + HRD+K +N+L T NA +KL DFG A+ + T TPY++APEV+ ++ Sbjct: 150 VIHRDIKGQNVLLTE---NAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN 206 Query: 240 ----YDKSCDMWSLGVIMYILLCGYPPFYSNH 267 YD D+WS G+ + G PP H Sbjct: 207 PDATYDYRSDLWSCGITAIEMAEGAPPLCDMH 238 >3OHT-A nrPDB Length = 389 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 57/205 (27%), Positives = 99/205 (48%), Gaps = 22/205 (10%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRIVD 122 +G G G V ++ ++ K A+K L + RE+ L + + +++ ++D Sbjct: 59 VGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRTYRELRL-LKHMKHENVIGLLD 117 Query: 123 VYE---NLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 V+ +L L+ L G +L + ++ Q T+ ++ I ++Y+HS Sbjct: 118 VFTPATSLEEFNDVYLVTH--LMGADLNNIVKC---QKLTDDHVQFLIYQILRGLKYIHS 172 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV-LGPE 238 +I HRD+KP NL + + LK+ DFG A+ T + +T T +Y APE+ L Sbjct: 173 ADIIHRDLKPSNL---AVNEDCELKILDFGLARHTD--DEMTGYVATRWYRAPEIMLNWM 227 Query: 239 KYDKSCDMWSLGVIMYILLCGYPPF 263 Y+ + D+WS+G IM LL G F Sbjct: 228 HYNMTVDIWSVGCIMAELLTGRTLF 252 >2BPM-A nrPDB Length = 309 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 75/298 (25%), Positives = 129/298 (43%), Gaps = 53/298 (17%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKML------QDCPK-ARREVELHWRASQCPHIVRIVD 122 +G G G V + NK T E ALK + + P A RE+ L + P+IV+++D Sbjct: 15 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISL-LKELNHPNIVKLLD 73 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS----IGEAIQYLH 178 V L +V E L ++ D + ++KS + + + + H Sbjct: 74 VIHT----ENKLYLVFEFLH-----QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 124 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYYVAPEV-LG 236 S + HRD+KP+NLL ++ +KL DFG A+ + T T +Y APE+ LG Sbjct: 125 SHRVLHRDLKPQNLLINTE---GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 181 Query: 237 PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL---------------AISPGMKTRIRM 281 + Y + D+WSLG I ++ F + + + PG+ + M Sbjct: 182 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS---M 238 Query: 282 GQYEFPNPEWSE---------VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTK 330 Y+ P+W+ + E+ + L+ +L +P +R++ + HP+ TK Sbjct: 239 PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 296 >3VN9-A nrPDB Length = 340 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 75/274 (27%), Positives = 126/274 (45%), Gaps = 36/274 (13%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRASQCPHIVRIVDV 123 LG G G V ++ + + + A+K + Q+ + ++++ R CP V Sbjct: 59 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTF--- 115 Query: 124 YENLYAGRKCLLIVMECLDGG--ELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS-I 180 Y L+ + I ME +D + + ++ D+G Q E +I SI +A+++LHS + Sbjct: 116 YGALFR-EGDVWICMELMDTSLDKFYKQVIDKG-QTIPEDILGKIAVSIVKALEHLHSKL 173 Query: 181 NIAHRDVKPENLLYTSKRPNAI--LKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPE 238 ++ HRDVKP N+L NA+ +K+ DFG + + T Y+APE + PE Sbjct: 174 SVIHRDVKPSNVLI-----NALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPE 228 Query: 239 ----KYDKSCDMWSLGVIMYIL-LCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW-- 291 Y D+WSLG+ M L + +P Y + G +P + + + E P+P+ Sbjct: 229 LNQKGYSVKSDIWSLGITMIELAILRFP--YDSWG---TPFQQLKQVV---EEPSPQLPA 280 Query: 292 SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 + S E LK +R T E M HP+ Sbjct: 281 DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 >2F9G-A nrPDB Length = 353 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 84/317 (26%), Positives = 137/317 (43%), Gaps = 66/317 (20%) Query: 59 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ--DCP----KARREVEL--HWR 110 I D+++ S +LG G G V +K T E A+K ++ D P + RE+++ H++ Sbjct: 9 ISSDFQLKS-LLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK 67 Query: 111 ASQCPHIVRIV--DVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMK 168 I I D +EN + +++ L +L I Q ++ + Sbjct: 68 HENIITIFNIQRPDSFENFNE-----VYIIQELMQTDLHRVI---STQMLSDDHIQYFIY 119 Query: 169 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK---ETTSHNS------ 219 A++ LH N+ HRD+KP NLL S N LK+ DFG A+ E+ + NS Sbjct: 120 QTLRAVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQ 176 Query: 220 --LTTPCYTPYYVAPEV-LGPEKYDKSCDMWSLGVIMYILLCGYPPF----YSNHGLAI- 271 +T T +Y APEV L KY ++ D+WS G I+ L P F Y + L I Sbjct: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIF 236 Query: 272 ----SPGMKTRIRMGQYEFPNPEWSEVSEEVKM-------------------LIRNLLKT 308 +P +R + +P E + + M L++ +L Sbjct: 237 GIIGTPHSDNDLRCIE----SPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVF 292 Query: 309 EPTQRMTITEFMNHPWI 325 +P +R+T E + HP++ Sbjct: 293 DPAKRITAKEALEHPYL 309 >4O2Z-A nrPDB Length = 377 Score = 67.8 bits (164), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 51/197 (25%), Positives = 91/197 (46%), Gaps = 17/197 (8%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKM-------LQDCPKARREVEL--HWRASQCPHIV 118 ++LG+G G + T EK ++K ++D + RE+++ + ++V Sbjct: 51 KILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREIDMMRFFHHENLLNVV 110 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 I+ + Y + + +V +D + + R Q E + I ++YLH Sbjct: 111 NILPPLKREYHSFEDVYVVTPLMD---VDMNVVLRSRQVLEESHMQYFVYQILRGLKYLH 167 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET-TSHNSLTTPCYTPYYVAPEVLGP 237 S N+AHRD+KP NL+ + LK+ DFG ++ ++ LT T +Y PE+L Sbjct: 168 SANVAHRDLKPANLV---TNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPELLLE 224 Query: 238 E-KYDKSCDMWSLGVIM 253 Y + D+WS+G I Sbjct: 225 NTNYSTAVDIWSVGCIF 241 >1V0B-A nrPDB Length = 288 Score = 67.8 bits (164), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 60/203 (29%), Positives = 94/203 (46%), Gaps = 20/203 (9%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKML------QDCPKAR-REVELHWRASQCPHIVRIVD 122 +G G G V + N E FALK + + P RE+ + + + +IV++ D Sbjct: 10 IGEGTYGVVYKAQNNYG-ETFALKKIRLEKEDEGIPSTTIREISI-LKELKHSNIVKLYD 67 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182 V +K L++V E LD + ++ D + A + + I Y H + Sbjct: 68 VIHT----KKRLVLVFEHLD--QDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRRV 121 Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYYVAPEVL-GPEKY 240 HRD+KP+NLL + LK+ DFG A+ T T +Y AP+VL G +KY Sbjct: 122 LHRDLKPQNLLINREGE---LKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKKY 178 Query: 241 DKSCDMWSLGVIMYILLCGYPPF 263 + D+WS+G I ++ G P F Sbjct: 179 STTIDIWSVGCIFAEMVNGAPLF 201 >4IDT-A nrPDB Length = 356 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 64/202 (31%), Positives = 95/202 (47%), Gaps = 19/202 (9%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIV--RIVDVYENL 127 LG G G+V ++ +K+T + A+K K R EV C + RIV +Y + Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVK------KVRLEVFRAEELMACAGLTSPRIVPLYGAV 135 Query: 128 YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDV 187 G + I ME L+GG L ++++G E A + E ++YLHS I H DV Sbjct: 136 REG-PWVNIFMELLEGGSLGQLVKEQG--CLPEDRALYYLGQALEGLEYLHSRRILHGDV 192 Query: 188 KPENLLYTSKRPNAILKLTDFGFA---KETTSHNSLTTPCYTP---YYVAPEVLGPEKYD 241 K +N+L +S +A L DFG A + L T Y P ++APEV+ D Sbjct: 193 KADNVLLSSDGSHA--ALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCD 250 Query: 242 KSCDMWSLGVIMYILLCGYPPF 263 D+WS +M +L G P+ Sbjct: 251 AKVDVWSSCCMMLHMLNGCHPW 272 >5TE0-A nrPDB Length = 347 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 72/261 (27%), Positives = 114/261 (43%), Gaps = 37/261 (14%) Query: 76 GKVLQIFNKRTQE--KFALKML-----QDCPKARREVELHWRASQCPHIVRIVDVYENLY 128 G +F RT K ALK + D +RE+++ S +IV +D N Sbjct: 30 GGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNV 89 Query: 129 AGRKC--LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN--IAH 184 + +LI+M+ GG++ + + R FTE E +I EA+ LH I H Sbjct: 90 SSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIH 149 Query: 185 RDVKPENLLYTSKRPNAILKLTDFGFAK------ETTSHNSLTTPC--YTPY-YVAPEVL 235 RD+K EN+L + L DFG A +T N++ YT Y APE++ Sbjct: 150 RDLKVENILLHDRGHYV---LCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMV 206 Query: 236 G---PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWS 292 + D+W+LG ++Y LC + + +AI G F P+ S Sbjct: 207 NLYSGKIITTKADIWALGCLLY-KLCYFTLPFGESQVAICDG----------NFTIPDNS 255 Query: 293 EVSEEVKMLIRNLLKTEPTQR 313 S+++ LIR +L+ +P +R Sbjct: 256 RYSQDMHCLIRYMLEPDPDKR 276 >2VD5-A nrPDB Length = 412 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 57/218 (26%), Positives = 101/218 (46%), Gaps = 17/218 (7%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHI--- 117 DD+++ +V+G G +V + K+T + +A+K++ +R +R + + Sbjct: 61 DDFEIL-KVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGD 119 Query: 118 VRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL 177 R + + L +VME GG+L + + G++ E A + I AI + Sbjct: 120 RRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEM-ARFYLAEIVMAIDSV 178 Query: 178 HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTT--PCYTPYYVAPEVL 235 H + HRD+KP+N+L R I +L DFG + + ++ + TP Y++PE+L Sbjct: 179 HRLGYVHRDIKPDNILL--DRCGHI-RLADFGSCLKLRADGTVRSLVAVGTPDYLSPEIL 235 Query: 236 GPEKYDK-------SCDMWSLGVIMYILLCGYPPFYSN 266 CD W+LGV Y + G PFY++ Sbjct: 236 QAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYAD 273 >4KRC-A nrPDB Length = 317 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 61/205 (29%), Positives = 90/205 (43%), Gaps = 19/205 (9%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKML-----QDCPK-ARREVELHWRASQCPHIVRIVDV 123 LG G V + NK T ALK + + P A RE+ L + + +IVR+ DV Sbjct: 13 LGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLM-KELKHENIVRLYDV 71 Query: 124 YENLYAGRKCLLIVMECLDGG---ELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 L +V E +D + SR + + + + + H Sbjct: 72 IHT----ENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHEN 127 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYYVAPEVL-GPE 238 I HRD+KP+NLL + LKL DFG A+ N+ ++ T +Y AP+VL G Sbjct: 128 KILHRDLKPQNLLINKR---GQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 Query: 239 KYDKSCDMWSLGVIMYILLCGYPPF 263 Y S D+WS G I+ ++ G P F Sbjct: 185 TYSTSIDIWSCGCILAEMITGKPLF 209 >4MD7-E nrPDB Length = 391 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 53/207 (25%), Positives = 84/207 (40%), Gaps = 35/207 (16%) Query: 156 QAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT 215 Q T+ + M I +A+ Y HS+ I HRDVKP N++ + L+L D+G A+ Sbjct: 126 QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYH 183 Query: 216 SHNSLTTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH------- 267 + Y+ PE+L + YD S DMWSLG ++ ++ PF+ H Sbjct: 184 PGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLV 243 Query: 268 ------------------GLAISP------GMKTRIRMGQYEFPNPEWSEVSEEVKMLIR 303 + + P G +R R ++ + VS E + Sbjct: 244 RIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQ-HLVSPEALDFLD 302 Query: 304 NLLKTEPTQRMTITEFMNHPWIMQSTK 330 LL+ + R+T E M HP+ K Sbjct: 303 KLLRYDHQSRLTAREAMEHPYFYTVVK 329 >3KUL-B nrPDB Length = 325 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 41/156 (26%), Positives = 79/156 (50%), Gaps = 13/156 (8%) Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 P+I+R+ E + + +IV E ++ G L + ++ D FT + +++ +G + Sbjct: 110 PNIIRL----EGVVTRGRLAMIVTEYMENGSLDTFLRTH-DGQFTIMQLVGMLRGVGAGM 164 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK---ETTSHNSLTTPCYTPY-YV 230 +YL + HRD+ N+L S N + K++DFG ++ + TT P + Sbjct: 165 RYLSDLGYVHRDLAARNVLVDS---NLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWT 221 Query: 231 APEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPFYS 265 APE + + + D+WS GV+M+ +L G P+++ Sbjct: 222 APEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWN 257 >4GS6-A nrPDB Length = 315 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 41/136 (30%), Positives = 71/136 (52%), Gaps = 12/136 (8%) Query: 134 LLIVMECLDGGELFSRIQDRGDQ---AFTEREASEIMKSIGEAIQYLHSIN---IAHRDV 187 + +VME +GG L++ + G + +T A + + YLHS+ + HRD+ Sbjct: 75 VCLVMEYAEGGSLYNVLH--GAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDL 132 Query: 188 KPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMW 247 KP NLL + +LK+ DFG A + +H +T + ++APEV Y + CD++ Sbjct: 133 KPPNLLLVAG--GTVLKICDFGTACDIQTH--MTNNKGSAAWMAPEVFEGSNYSEKCDVF 188 Query: 248 SLGVIMYILLCGYPPF 263 S G+I++ ++ PF Sbjct: 189 SWGIILWEVITRRKPF 204 >2VWV-A nrPDB Length = 302 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 56/217 (25%), Positives = 104/217 (47%), Gaps = 23/217 (10%) Query: 63 YKVTSQVLGLGINGKVLQIFNK---RTQEKFALKMLQDCPKARREVELHWRAS-----QC 114 Y +V+G G G+V + K + + A+K L+ R+ E AS + Sbjct: 17 YVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEH 76 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 P+I+R+ V N ++I+ E ++ G L S ++ D FT + +++ I + Sbjct: 77 PNIIRLEGVVTNSMP----VMILTEFMENGALDSFLR-LNDGQFTVIQLVGMLRGIASGM 131 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFG---FAKETTSHNSLTTPCYTPY--- 228 +YL ++ HRD+ N+L S N + K++DFG F +E +S + T+ Sbjct: 132 RYLAEMSYVHRDLAARNILVNS---NLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIR 188 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPFY 264 + APE + K+ + D WS G++M+ ++ G P++ Sbjct: 189 WTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYW 225 >6EII-A nrPDB Length = 352 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 53/207 (25%), Positives = 84/207 (40%), Gaps = 35/207 (16%) Query: 156 QAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT 215 Q T+ + M I +A+ Y HS+ I HRDVKP N++ + L+L D+G A+ Sbjct: 149 QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRK--LRLIDWGLAEFYH 206 Query: 216 SHNSLTTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH------- 267 + Y+ PE+L + YD S DMWSLG ++ ++ PF+ H Sbjct: 207 PGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLV 266 Query: 268 ------------------GLAISP------GMKTRIRMGQYEFPNPEWSEVSEEVKMLIR 303 + + P G +R R ++ + VS E + Sbjct: 267 RIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQ-HLVSPEALDFLD 325 Query: 304 NLLKTEPTQRMTITEFMNHPWIMQSTK 330 LL+ + R+T E M HP+ K Sbjct: 326 KLLRYDHQSRLTAREAMEHPYFYTVVK 352 >6HMD-A nrPDB Length = 365 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 59/220 (26%), Positives = 94/220 (42%), Gaps = 37/220 (16%) Query: 156 QAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT 215 Q T+ + M + +A+ Y HS I HRDVKP N++ ++ L+L D+G A+ Sbjct: 142 QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKK--LRLIDWGLAEFYH 199 Query: 216 SHNSLTTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHG------ 268 + Y+ PE+L + YD S DMWSLG ++ ++ PF+ HG Sbjct: 200 PAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFF--HGQDNYDQ 257 Query: 269 -LAISPGMKTRIRMG---QYEFP-NPEWSE---------------------VSEEVKMLI 302 + I+ + T G +Y +P +++ VS E L+ Sbjct: 258 LVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLL 317 Query: 303 RNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVL 342 LL+ + QR+T E M HP+ K P + VL Sbjct: 318 DKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPSADNAVL 357 >2H34-A nrPDB Length = 309 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 97/209 (46%), Gaps = 18/209 (8%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDC----PKARREVELHWRAS---QCPHIVRI 120 +++G G G V + + + ALK++ + P R ++ R + Q PH+V I Sbjct: 40 RLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPHVVPI 99 Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 D E G+ L + M ++G +L + ++ +G A I++ IG A+ H+ Sbjct: 100 HDFGE--IDGQ--LYVDMRLINGVDLAAMLRRQG--PLAPPRAVAIVRQIGSALDAAHAA 153 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSH--NSLTTPCYTPYYVAPEVLGPE 238 HRDVKPEN+L ++ + L DFG A TT L T YY+APE Sbjct: 154 GATHRDVKPENILVSA---DDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSES 210 Query: 239 KYDKSCDMWSLGVIMYILLCGYPPFYSNH 267 D+++L ++Y L G PP+ + Sbjct: 211 HATYRADIYALTCVLYECLTGSPPYQGDQ 239 >4PL5-B nrPDB Length = 435 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 70/272 (25%), Positives = 126/272 (46%), Gaps = 30/272 (11%) Query: 69 VLGLGINGKVLQ--IFNKRTQEKFALKMLQDCPK-ARREVELHWRASQCPHIVRIVDVYE 125 VLG G G ++ +F+ R + ++L +C A REV+L + + P+++R Y Sbjct: 34 VLGHGAEGTIVYKGMFDNR--DVAVKRILPECFSFADREVQLLRESDEHPNVIR----YF 87 Query: 126 NLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHR 185 R+ I +E L L ++ + D A E ++ + +LHS+NI HR Sbjct: 88 CTEKDRQFQYIAIE-LCAATLQEYVEQK-DFAHLGLEPITLLHQTTSGLAHLHSLNIVHR 145 Query: 186 DVKPENLLYTSKRPNAILK--LTDFGFAKE-TTSHNSLTTPCYTP---YYVAPEVLGPEK 239 D+KP N+L + + +K ++DFG K+ +S + P ++APE+L + Sbjct: 146 DLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDC 205 Query: 240 YDK---SCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 295 D + D++S G + Y ++ GY PF S + I +G + S+ Sbjct: 206 KDNPTYTVDIFSAGCVFYYVISEGYHPF------GKSLQRQANILLGACNL-DCFHSDKH 258 Query: 296 EEV--KMLIRNLLKTEPTQRMTITEFMNHPWI 325 E+V + LI ++ +P QR + + HP+ Sbjct: 259 EDVIARELIEKMIAMDPQQRPSAKHVLKHPFF 290 >4XLV-A nrPDB Length = 328 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 64/269 (23%), Positives = 111/269 (41%), Gaps = 31/269 (11%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRAS-----QCPHIVRIVDVY 124 G+ G I + + A+K + + R +E AS C H+VR++ V Sbjct: 52 FGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVV 111 Query: 125 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAF--------TEREASEIMKSIGEAIQY 176 + + L+VME + G+L S ++ +A T +E ++ I + + Y Sbjct: 112 ----SKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAY 167 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK---ETTSHNSLTTPCYTPYYVAPE 233 L++ HRD+ N + + +K+ DFG + ET + ++APE Sbjct: 168 LNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPE 224 Query: 234 VLGPEKYDKSCDMWSLGVIMY-ILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWS 292 L + S DMWS GV+++ I P+ GL+ +K + G + P+ Sbjct: 225 SLKDGVFTTSSDMWSFGVVLWEITSLAEQPY---QGLSNEQVLKFVMDGGYLDQPD---- 277 Query: 293 EVSEEVKMLIRNLLKTEPTQRMTITEFMN 321 E V L+R + P R T E +N Sbjct: 278 NCPERVTDLMRMCWQFNPNMRPTFLEIVN 306 >4E93-A nrPDB Length = 377 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 54/224 (24%), Positives = 102/224 (45%), Gaps = 30/224 (13%) Query: 49 KSGLQIKKNAIIDDYKVTSQVLGLG---INGKVLQIFNKRTQEKFALKMLQDC------- 98 KSG+ + + D + + + L LG G ++F+ R + L ++ C Sbjct: 95 KSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPD 154 Query: 99 --PKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQ 156 K +E + + S P+IVR++ V ++ + IVME + GG+ + ++ G + Sbjct: 155 LKAKFLQEARILKQYSH-PNIVRLIGVCTQ----KQPIYIVMELVQGGDFLTFLRTEGAR 209 Query: 157 AFTEREASEIMKSIGEA---IQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE 213 +++ +G+A ++YL S HRD+ N L T K +LK++DFG ++E Sbjct: 210 L----RVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKN---VLKISDFGMSRE 262 Query: 214 TTSHNSLTTPCYTPY---YVAPEVLGPEKYDKSCDMWSLGVIMY 254 + + APE L +Y D+WS G++++ Sbjct: 263 EADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLW 306 >3FME-A nrPDB Length = 290 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 74/273 (27%), Positives = 123/273 (45%), Gaps = 34/273 (12%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRASQCPHIVRIVDV 123 LG G G V ++ + + + A+K + Q+ + ++++ R CP V Sbjct: 15 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTF--- 71 Query: 124 YENLYAGRKCLLIVMECLDGG--ELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS-I 180 Y L+ + I ME +D + + ++ D+G Q E +I SI +A+++LHS + Sbjct: 72 YGALFR-EGDVWICMELMDTSLDKFYKQVIDKG-QTIPEDILGKIAVSIVKALEHLHSKL 129 Query: 181 NIAHRDVKPENLLYTSKRPNAI--LKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPE 238 ++ HRDVKP N+L NA+ +K+ DFG + + Y+APE + PE Sbjct: 130 SVIHRDVKPSNVLI-----NALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPERINPE 184 Query: 239 ----KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW--S 292 Y D+WSLG+ M L P Y + G +P + + + E P+P+ Sbjct: 185 LNQKGYSVKSDIWSLGITMIELAILRFP-YDSWG---TPFQQLKQVV---EEPSPQLPAD 237 Query: 293 EVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 + S E LK +R T E M HP+ Sbjct: 238 KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 270 >1JPA-A nrPDB Length = 312 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 56/216 (25%), Positives = 104/216 (48%), Gaps = 31/216 (14%) Query: 68 QVLGLGINGKV----LQIFNKRTQEKF-ALKMLQDCPKARREVELHWRAS-----QCPHI 117 QV+G G G+V L++ KR E F A+K L+ ++ + AS P++ Sbjct: 39 QVIGAGEFGEVCSGHLKLPGKR--EIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNV 96 Query: 118 VRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL 177 + + E + ++I+ E ++ G L S ++ + D FT + +++ I ++YL Sbjct: 97 IHL----EGVVTKSTPVMIITEFMENGSLDSFLR-QNDGQFTVIQLVGMLRGIAAGMKYL 151 Query: 178 HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY--------Y 229 +N HRD+ N+L S N + K++DFG ++ S P YT + Sbjct: 152 ADMNYVHRDLAARNILVNS---NLVCKVSDFGLSRFLEDDTS--DPTYTSALGGKIPIRW 206 Query: 230 VAPEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPFY 264 APE + K+ + D+WS G++M+ ++ G P++ Sbjct: 207 TAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYW 242 >4IC8-A nrPDB Length = 442 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 77/343 (22%), Positives = 146/343 (42%), Gaps = 62/343 (18%) Query: 37 PPPPQQFPQFHVKSGLQIKKNAII------------DDYKVTSQVLGLGINGKVLQIFNK 84 PP P + H + + K A++ D+Y++ + +G G G V + Sbjct: 19 PPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEII-ETIGNGAYGVVSSARRR 77 Query: 85 RTQEKFALK-------MLQDCPKARREVEL--HWRASQCPHIVRIVDVYENL--YAGRKC 133 T ++ A+K ++ + + RE+++ H++ +I+ I D+ Y K Sbjct: 78 LTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD---NIIAIKDILRPTVPYGEFKS 134 Query: 134 LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL 193 + +V++ ++ +L I Q T + + ++Y+HS + HRD+KP NLL Sbjct: 135 VYVVLDLMES-DLHQIIH--SSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLL 191 Query: 194 YTSKRPNAILKLTDFGFAKETTSHNS-----LTTPCYTPYYVAPEV-LGPEKYDKSCDMW 247 N LK+ DFG A+ + + +T T +Y APE+ L +Y ++ D+W Sbjct: 192 VNE---NCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLW 248 Query: 248 SLGVIMYILLCG---YPPFYSNHGLAI--------SPGM-----KTRIRMGQYEFPNPE- 290 S+G I +L +P H L + SP + R+R P + Sbjct: 249 SVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQP 308 Query: 291 --WSEV----SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 W V + L+ +L+ EP+ R++ + HP++ + Sbjct: 309 VPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAK 351 >2BUJ-A nrPDB Length = 317 Score = 65.1 bits (157), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 70/305 (22%), Positives = 137/305 (44%), Gaps = 31/305 (10%) Query: 58 AIIDD-YKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-----QDCPKARREVELHWRA 111 IID+ + + Q LG G V + +ALK + QD +A+RE ++H R Sbjct: 24 VIIDNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMH-RL 82 Query: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFS---RIQDRGDQAFTEREASEIMK 168 P+I+R+V + +++ G L++ R++D+G+ TE + ++ Sbjct: 83 FNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGN-FLTEDQILWLLL 141 Query: 169 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDF--------GFAKETTSHNSL 220 I ++ +H+ AHRD+KP N+L + ++ L G + T + Sbjct: 142 GICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWA 201 Query: 221 TTPCYTPYYVAPEVLGPEKY---DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKT 277 C T Y APE+ + + D+ D+WSLG ++Y ++ G P+ + G Sbjct: 202 AQRC-TISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPY----DMVFQKGDSV 256 Query: 278 RIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLH 337 + + Q + P+ S + L+ +++ +P QR I ++ +++ + P H Sbjct: 257 ALAV-QNQLSIPQSPRHSSALWQLLNSMMTVDPHQRPHIPLLLSQ---LEALQPPAPGQH 312 Query: 338 TSRVL 342 T+++L Sbjct: 313 TTQIL 317 >4Y83-A nrPDB Length = 332 Score = 65.1 bits (157), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 53/217 (24%), Positives = 99/217 (45%), Gaps = 17/217 (7%) Query: 53 QIKKNAIIDDYKVTSQVLG-----LGINGKVLQIFNKRTQEKFALKMLQDCPKARREVEL 107 QI + ++ +K+T + +G G GKV + +T+++ A K++ +VE+ Sbjct: 59 QIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEI 118 Query: 108 HWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIM 167 C I ++Y + G L ME +GG + +++ G E E + Sbjct: 119 Q----ACFRHENIAELYGAVLWGETVHLF-MEAGEGGSVLEKLESCG--PMREFEIIWVT 171 Query: 168 KSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY-T 226 K + + + +LHS + H D+KP N+++ S + L DFG + + T T Sbjct: 172 KHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKA----VLVDFGLSVQMTEDVYFPKDLRGT 227 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPF 263 Y++PEV+ + D++SLG + + G PP+ Sbjct: 228 EIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPW 264 >3MIA-A nrPDB Length = 351 Score = 64.7 bits (156), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 75/298 (25%), Positives = 120/298 (40%), Gaps = 49/298 (16%) Query: 70 LGLGINGKVLQIFNKRTQEKFALK-MLQDCPK------ARREVEL-----HWRASQCPHI 117 +G G G+V + +++T +K ALK +L + K A RE+++ H I Sbjct: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEI 84 Query: 118 VRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL 177 R N G L+ D L S + + FT E +M+ + + Y+ Sbjct: 85 CRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK----FTLSEIKRVMQMLLNGLYYI 140 Query: 178 HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK-----ETTSHNSLTTPCYTPYYVAP 232 H I HRD+K N+L T + +LKL DFG A+ + + N T T +Y P Sbjct: 141 HRNKILHRDMKAANVLITR---DGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 Query: 233 E-VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSN---HGLA------------ISPGMK 276 E +LG Y D+W G IM + P N H LA + P + Sbjct: 198 ELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVD 257 Query: 277 TRIRMGQYEFPNPEWSEVSEEVKMLIRN---------LLKTEPTQRMTITEFMNHPWI 325 + E + +V + +K +R+ LL +P QR+ + +NH + Sbjct: 258 NYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 >3RP9-A nrPDB Length = 458 Score = 64.7 bits (156), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 63/243 (25%), Positives = 105/243 (43%), Gaps = 63/243 (25%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM-------LQDCPKARREVELHWRASQ 113 D Y++ ++G G G V + ++K + A+K L DC + RE+ + R + Sbjct: 53 DRYEI-RHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNRLNH 111 Query: 114 CPHIVRIVDV--------YENLYAGRKCLLIVMECLDGG--ELFSRIQDRGDQAFTEREA 163 H+V+++D+ ++ LY +V+E D +LF R TE Sbjct: 112 -DHVVKVLDIVIPKDVEKFDELY-------VVLEIADSDFKKLF-----RTPVYLTELHI 158 Query: 164 SEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT---SHNS- 219 ++ ++ ++Y+HS I HRD+KP N L + +K+ DFG A+ + NS Sbjct: 159 KTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQ---DCSVKVCDFGLARTVDYPENGNSQ 215 Query: 220 ------------------------LTTPCYTPYYVAPE-VLGPEKYDKSCDMWSLGVIMY 254 LT T +Y APE +L E Y ++ D+WS+G I Sbjct: 216 LPISPREDDMNLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFA 275 Query: 255 ILL 257 LL Sbjct: 276 ELL 278 >2RIO-A nrPDB Length = 434 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 79/312 (25%), Positives = 135/312 (43%), Gaps = 45/312 (14%) Query: 65 VTSQVLGLGINGKVLQIFNKRTQEK-FALK-MLQD-CPKARREVELHWRASQCPHIVRIV 121 V+ ++LG G +G V +F Q + A+K ML D C A E++L + P+++R Sbjct: 18 VSEKILGYGSSGTV--VFQGSFQGRPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIR-- 73 Query: 122 DVYENLYAGRKCLLIVMEC--LDGGELFS--RIQDRGDQAFTEREASEIMKSIGEAIQYL 177 Y + L I +E L+ +L + D + E +++ I + +L Sbjct: 74 --YYCSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHL 131 Query: 178 HSINIAHRDVKPENLLY-TSKR---------PNAILKLTDFGFAKETTSHNS-----LTT 222 HS+ I HRD+KP+N+L TS R N + ++DFG K+ S S L Sbjct: 132 HSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNN 191 Query: 223 PCYTPYYVAPEVL-------GPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPG 274 P T + APE+L + +S D++S+G + Y +L G PF + Sbjct: 192 PSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKY------S 245 Query: 275 MKTRIRMGQYEFPNPEW---SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKV 331 ++ I G + + + E LI ++ +P +R T + + HP +K Sbjct: 246 RESNIIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRHPLFWPKSKK 305 Query: 332 PQTPLHTSRVLK 343 + L S L+ Sbjct: 306 LEFLLKVSDRLE 317 >3NIE-A nrPDB Length = 429 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 68/245 (27%), Positives = 107/245 (43%), Gaps = 49/245 (20%) Query: 51 GLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM-------LQDCPKARR 103 G IK + D+Y++ ++G G G V ++K + A+K L DC + R Sbjct: 18 GAIIKNVKVPDNYEI-KHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILR 76 Query: 104 EVELHWRASQCPHIVRIVDVY--ENLYAGRKCLLIVMECLDGG--ELFSRIQDRGDQAFT 159 E+ + R + +I+R+ D+ E+L + L IV+E D +LF + T Sbjct: 77 EITILNRL-KSDYIIRLHDLIIPEDLLKFDE-LYIVLEIADSDLKKLF-----KTPIFLT 129 Query: 160 EREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS--- 216 E+ I+ ++ +++H I HRD+KP N L + +K+ DFG A+ S Sbjct: 130 EQHVKTILYNLLLGEKFIHESGIIHRDLKPANCLLNQ---DCSVKICDFGLARTINSDKD 186 Query: 217 ------------------HNS-----LTTPCYTPYYVAPE-VLGPEKYDKSCDMWSLGVI 252 HN LT+ T +Y APE +L E Y S D+WS G I Sbjct: 187 IHIVNDLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCI 246 Query: 253 MYILL 257 LL Sbjct: 247 FAELL 251 Score = 27.7 bits (60), Expect = 9.8, Method: Compositional matrix adjust. Identities = 12/53 (22%), Positives = 30/53 (56%) Query: 290 EWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVL 342 ++S +S+E L+ ++L+ +R+TI + ++HP++ K T +++ Sbjct: 335 KYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVRKENLENFSTEKII 387 >3PPZ-A nrPDB Length = 309 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 51/192 (26%), Positives = 91/192 (47%), Gaps = 13/192 (6%) Query: 134 LLIVMECLDGGELFSRIQDRGD-QAFTEREASEIMKSIGEAIQYLHSIN--IAHRDVKPE 190 L IV E L G L+ + G + ER + + + + YLH+ N I HRD+K Sbjct: 109 LSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSP 168 Query: 191 NLLYTSKRPNAILKLTDFGFAK-ETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSL 249 NLL K +K+ DFG ++ + ++ S + TP ++APEVL E ++ D++S Sbjct: 169 NLLVDKK---YTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPSNEKSDVYSF 225 Query: 250 GVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTE 309 GVI++ L P+ + + + + + + + E P ++ +V +I E Sbjct: 226 GVILWELATLQQPWGNLNPAQVVAAVGFKCK--RLEIPR----NLNPQVAAIIEGCWTNE 279 Query: 310 PTQRMTITEFMN 321 P +R + M+ Sbjct: 280 PWKRPSFATIMD 291 >4OLI-A nrPDB Length = 645 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 79/275 (28%), Positives = 126/275 (45%), Gaps = 35/275 (12%) Query: 70 LGLGINGKV-LQIF---NKRTQEKFALKMLQ-DC-PKAR----REVELHWRASQCPHIVR 119 LG G GKV L + N T E A+K L+ DC P+ R +E+++ R HI++ Sbjct: 361 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDI-LRTLYHEHIIK 419 Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 E+ G K L +VME + G L + + + + I E + YLHS Sbjct: 420 YKGCCED--QGEKSLQLVMEYVPLGSLRDYLPR---HSIGLAQLLLFAQQICEGMAYLHS 474 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAK---ETTSHNSLTTPCYTP-YYVAPEVL 235 + HR++ N+L + R ++K+ DFG AK E + + +P ++ APE L Sbjct: 475 QHYIHRNLAARNVLLDNDR---LVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECL 531 Query: 236 GPEKYDKSCDMWSLGVIMYILL--CG---YPPFYSNHGLAISPGMKTRIRMGQY-----E 285 K+ + D+WS GV +Y LL C PP + I+ G T +R+ + Sbjct: 532 KEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGER 591 Query: 286 FPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM 320 P P+ + EV L++N +TE + R T + Sbjct: 592 LPRPD--KCPCEVYHLMKNCWETEASFRPTFENLI 624 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 39/155 (25%), Positives = 61/155 (39%), Gaps = 19/155 (12%) Query: 166 IMKSIGEAIQYLHSINIAHRDVKPENLLYT----SKRPNAILKLTDFGFAKETTSHNSLT 221 + + + A+ YL + N+ H +V N+L ++ + +KL+D G S Sbjct: 172 VAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERV 231 Query: 222 TPCYTPYYVAPEVL--GPEKYDKSCDMWSLG-VIMYILLCGYPPFYSNHGLAISPGMKTR 278 P ++APE L G + D W G ++ I G P S SP K Sbjct: 232 E--RIP-WLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSR-----SPSEKEH 283 Query: 279 IRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQR 313 Q+ P P +++ L L EPTQR Sbjct: 284 FYQRQHRLPEPSCPQLA----TLTSQCLTYEPTQR 314 >2PVN-A nrPDB Length = 352 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 78/301 (25%), Positives = 134/301 (44%), Gaps = 45/301 (14%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQC--PHIV 118 DDY+V +V G G +V + N EK +K+L+ K + + E+ + C P+IV Sbjct: 52 DDYEVVRKV-GRGKYSEVFEGINVNNNEKCIIKILKPVKKKKIKREIKILQNLCGGPNIV 110 Query: 119 RIVDVYENLYAGRKCLLI-VMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL 177 +++D+ + ++ L+ + D L+ + D + + E++K A+ Y Sbjct: 111 KLLDIVRDQHSKTPSLIFEYVNNTDFKVLYPTLTDYDIRYYI----YELLK----ALDYC 162 Query: 178 HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-G 236 HS I HRDVKP N++ + L+L D+G A+ + Y+ PE+L Sbjct: 163 HSQGIMHRDVKPHNVMIDHELRK--LRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLVD 220 Query: 237 PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHG----------LAISPGM-----KTRIRM 281 + YD S DMWSLG + ++ PF+ H + + G+ K RI + Sbjct: 221 LQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYRIEL 280 Query: 282 --------GQY------EFPNPEWSE-VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIM 326 G++ +F N + VS E + LL+ + +R+T E M HP+ Sbjct: 281 DPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTHPYFQ 340 Query: 327 Q 327 Q Sbjct: 341 Q 341 >5UUU-A nrPDB Length = 547 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 67/287 (23%), Positives = 131/287 (45%), Gaps = 33/287 (11%) Query: 42 QFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKA 101 +F +F +++ + ++D+ V +++G G G+V T + +A+K L Sbjct: 179 KFTRFCQWKNVELNIHLTMNDFSV-HRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIK 237 Query: 102 RREVE---LHWR-------ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQ 151 ++ E L+ R CP IV + + L +++ ++GG+L + Sbjct: 238 MKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHT----PDKLSFILDLMNGGDLHYHLS 293 Query: 152 DRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFA 211 G F+E + I ++++H+ + +RD+KP N+L + ++++D G A Sbjct: 294 QHG--VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDE---HGHVRISDLGLA 348 Query: 212 KETTS---HNSLTTPCYTPYYVAPEVLGPE-KYDKSCDMWSLGVIMYILLCGYPPFYSNH 267 + + H S+ T Y +APEVL YD S D +SLG +++ LL G+ PF + Sbjct: 349 CDFSKKKPHASVGTHGY----MAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHK 404 Query: 268 GLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRM 314 + + M E P+ S E++ L+ LL+ + +R+ Sbjct: 405 TKDKHEIDRMTLTMA-VELPDS----FSPELRSLLEGLLQRDVNRRL 446 >3PVW-A nrPDB Length = 695 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 67/287 (23%), Positives = 131/287 (45%), Gaps = 33/287 (11%) Query: 42 QFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKA 101 +F +F +++ + ++D+ V +++G G G+V T + +A+K L Sbjct: 170 KFTRFCQWKNVELNIHLTMNDFSV-HRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIK 228 Query: 102 RREVE---LHWR-------ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQ 151 ++ E L+ R CP IV + + L +++ ++GG+L + Sbjct: 229 MKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHT----PDKLSFILDLMNGGDLHYHLS 284 Query: 152 DRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFA 211 G F+E + I ++++H+ + +RD+KP N+L + ++++D G A Sbjct: 285 QHG--VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDE---HGHVRISDLGLA 339 Query: 212 KETTS---HNSLTTPCYTPYYVAPEVLGPE-KYDKSCDMWSLGVIMYILLCGYPPFYSNH 267 + + H S+ T Y +APEVL YD S D +SLG +++ LL G+ PF + Sbjct: 340 CDFSKKKPHASVGTHGY----MAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHK 395 Query: 268 GLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRM 314 + + M E P+ S E++ L+ LL+ + +R+ Sbjct: 396 TKDKHEIDRMTLTMA-VELPDS----FSPELRSLLEGLLQRDVNRRL 437 >2OZO-A nrPDB Length = 613 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 65/265 (24%), Positives = 117/265 (44%), Gaps = 36/265 (13%) Query: 4 NSQGQSP-PVPFPAPAPP-PQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIID 61 NS G +P P +P P P P ++ P P + K + N +I Sbjct: 288 NSDGYTPEPARITSPDKPRPMPMDTSVFESPFSDPE-------ELKDKKLFLKRDNLLIA 340 Query: 62 DYKVTSQVLGLGINGKVLQ-IFNKRTQE-KFALKMLQ------DCPKARREVELHWRASQ 113 D + LG G G V Q ++ R ++ A+K+L+ D + RE ++ + Sbjct: 341 DIE-----LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN 395 Query: 114 CPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEA 173 P+IVR++ V + + L++VME GG L + + ++ +E++ + Sbjct: 396 -PYIVRLIGVCQA-----EALMLVMEMAGGGPLHKFLVGKREE-IPVSNVAELLHQVSMG 448 Query: 174 IQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTP----CYTPYY 229 ++YL N HR++ N+L ++ K++DFG +K + +S T + + Sbjct: 449 MKYLEEKNFVHRNLAARNVLLVNRH---YAKISDFGLSKALGADDSYYTARSAGKWPLKW 505 Query: 230 VAPEVLGPEKYDKSCDMWSLGVIMY 254 APE + K+ D+WS GV M+ Sbjct: 506 YAPECINFRKFSSRSDVWSYGVTMW 530 >5MJB-A nrPDB Length = 305 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 39/158 (24%), Positives = 80/158 (50%), Gaps = 19/158 (12%) Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 +I+R+ E + + ++I+ E ++ L S ++ + D FT + +++ I ++ Sbjct: 88 NIIRL----EGVVTKSRPVMIITEFMENCALDSFLR-QNDGQFTVIQLVGMLRGIAAGMK 142 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY------- 228 YL +N HRD+ N+L S N + K++DFG ++ + + P YT Sbjct: 143 YLSEMNYVHRDLAARNILVNS---NLVCKVSDFGLSRYL--QDDTSDPTYTSSLGGKIPV 197 Query: 229 -YVAPEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPFY 264 + APE + K+ + D+WS G++M+ ++ G P++ Sbjct: 198 RWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYW 235 >5H2U-A nrPDB Length = 267 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 40/136 (29%), Positives = 63/136 (46%), Gaps = 7/136 (5%) Query: 136 IVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT 195 I+ E + G L ++D ++ E +I + E + YL S N HRD+ N+L Sbjct: 79 IITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVG 138 Query: 196 SKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY-YVAPEVLGPEKYDKSCDMWSLGVIMY 254 N + K+ DFG A+ L+ PY + APE L Y D+WS G++++ Sbjct: 139 E---NTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLH 195 Query: 255 ILLC-GYPPF--YSNH 267 + G P+ SNH Sbjct: 196 EMFSRGQVPYPGMSNH 211 >5M07-A nrPDB Length = 276 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 48/167 (28%), Positives = 74/167 (44%), Gaps = 19/167 (11%) Query: 102 RREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTER 161 +RE E+ R PHI+ + D E + G+ L I M+ +DG + + DR Sbjct: 78 QRETEVAARLFH-PHILEVHDRGE--FDGQ--LWIAMDYVDGIDATQHMADRFPAVLPVG 132 Query: 162 EASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRP-NAILKLTDFGFAKETTSHNSL 220 E I+ ++ A+ Y H + HRDV P N++ TS+ + + L DFG A + Sbjct: 133 EVLAIVTAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ------- 185 Query: 221 TTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH 267 P Y APE+ D D ++L + L G PP +H Sbjct: 186 ------PSYPAPELSAGADVDGRADQYALALTAIHLFAGAPPVDRSH 226 >1U59-A nrPDB Length = 287 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 56/221 (25%), Positives = 102/221 (46%), Gaps = 23/221 (10%) Query: 61 DDYKVTSQVLGLGINGKVLQ-IFNKRTQE-KFALKMLQ------DCPKARREVELHWRAS 112 D+ + LG G G V Q ++ R ++ A+K+L+ D + RE ++ + Sbjct: 9 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 68 Query: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 P+IVR++ V + + L++VME GG L + + ++ +E++ + Sbjct: 69 N-PYIVRLIGVCQA-----EALMLVMEMAGGGPLHKFLVGKREE-IPVSNVAELLHQVSM 121 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTP----CYTPY 228 ++YL N HRD+ N+L ++ K++DFG +K + +S T + Sbjct: 122 GMKYLEEKNFVHRDLAARNVLLVNRH---YAKISDFGLSKALGADDSYYTARSAGKWPLK 178 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHG 268 + APE + K+ D+WS GV M+ L G P+ G Sbjct: 179 WYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKG 219 >5B2L-A nrPDB Length = 324 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 51/206 (24%), Positives = 94/206 (45%), Gaps = 21/206 (10%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRASQCPHIVRIVDV 123 +G G G+V ++ ++T A+K + ++ + ++++ ++ CP+IV+ Sbjct: 25 MGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCF-- 82 Query: 124 YENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN-I 182 + + I ME + G +++ R ER ++ +I +A+ YL + + Sbjct: 83 --GTFITNTDVFIAMELM--GTSAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGV 138 Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEK--- 239 HRDVKP N+L + +KL DFG + + T Y+APE + P Sbjct: 139 IHRDVKPSNILLDER---GQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTK 195 Query: 240 --YDKSCDMWSLGVIMYILLCGYPPF 263 YD D+WSLG+ + L G P+ Sbjct: 196 PDYDIRADVWSLGISLVELATGQFPY 221 >5KKR-C nrPDB Length = 395 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 61/211 (28%), Positives = 98/211 (46%), Gaps = 21/211 (9%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM--LQDCPKARREVELHWRASQCPHIV 118 DD++ S+ LG G G V ++ +K + A K+ L+ P R ++ R Q H Sbjct: 68 DDFEKISE-LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQI---IRELQVLHEC 123 Query: 119 R---IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 IV Y Y+ + + I ME +DGG L ++ G E+ ++ ++ + + Sbjct: 124 NSPYIVGFYGAFYSDGE-ISICMEHMDGGSLDQVLKKAG--RIPEQILGKVSIAVIKGLT 180 Query: 176 YLHSIN-IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSH--NSLTTPCYTPYYVAP 232 YL + I HRDVKP N+L S+ +KL DFG + + NS T Y++P Sbjct: 181 YLREKHKIMHRDVKPSNILVNSR---GEIKLCDFGVSGQLIDSMANSFVG---TRSYMSP 234 Query: 233 EVLGPEKYDKSCDMWSLGVIMYILLCGYPPF 263 E L Y D+WS+G+ + + G P Sbjct: 235 ERLQGTHYSVQSDIWSMGLSLVEMAVGRYPI 265 >4G3E-A nrPDB Length = 352 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 64/202 (31%), Positives = 94/202 (46%), Gaps = 19/202 (9%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIV--RIVDVYENL 127 +G G G+V ++ +K+T + A+K K R EV C + RIV +Y + Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVK------KVRLEVFRVEELVACAGLSSPRIVPLYGAV 135 Query: 128 YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDV 187 G + I ME L+GG L I+ G E A + E ++YLH+ I H DV Sbjct: 136 REG-PWVNIFMELLEGGSLGQLIKQMG--CLPEDRALYYLGQALEGLEYLHTRRILHGDV 192 Query: 188 KPENLLYTSKRPNAILKLTDFGFA---KETTSHNSLTTPCYTP---YYVAPEVLGPEKYD 241 K +N+L +S A L DFG A + SL T Y P ++APEV+ + D Sbjct: 193 KADNVLLSSDGSRA--ALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCD 250 Query: 242 KSCDMWSLGVIMYILLCGYPPF 263 D+WS +M +L G P+ Sbjct: 251 AKVDIWSSCCMMLHMLNGCHPW 272 >6DBM-A nrPDB Length = 318 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 77/275 (28%), Positives = 122/275 (44%), Gaps = 35/275 (12%) Query: 70 LGLGINGKV-LQIF---NKRTQEKFALKML------QDCPKARREVELHWRASQCPHIVR 119 LG G GKV L + N T E A+K L Q ++E+++ R HI++ Sbjct: 39 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQEIDI-LRTLYHEHIIK 97 Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 E+ AG L +VME + G L + + + + I E + YLHS Sbjct: 98 YKGCCED--AGAASLQLVMEYVPLGSLRDYLPR---HSIGLAQLLLFAQQICEGMAYLHS 152 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAK---ETTSHNSLTTPCYTP-YYVAPEVL 235 + HRD+ N+L + R ++K+ DFG AK E + + +P ++ APE L Sbjct: 153 QHYIHRDLAARNVLLDNDR---LVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECL 209 Query: 236 GPEKYDKSCDMWSLGVIMYILL--CG---YPPFYSNHGLAISPGMKTRIRMGQY-----E 285 K+ + D+WS GV +Y LL C PP + I+ G T +R+ + Sbjct: 210 KEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGER 269 Query: 286 FPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM 320 P P+ + EV L++N +TE + R T + Sbjct: 270 LPRPD--KCPAEVYHLMKNCWETEASFRPTFENLI 302 >2Y6O-A nrPDB Length = 291 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 38/140 (27%), Positives = 75/140 (53%), Gaps = 11/140 (7%) Query: 132 KC--LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKP 189 KC ++I+ E ++ G L + ++ + D FT + +++ IG ++YL ++ HRD+ Sbjct: 86 KCKPVMIITEYMENGSLDAFLR-KNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAA 144 Query: 190 ENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCYT--PYYVAPEVLGPEKYDKSCD 245 N+L S N + K++DFG ++ E + TT + APE + K+ + D Sbjct: 145 RNILVNS---NLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASD 201 Query: 246 MWSLGVIMY-ILLCGYPPFY 264 +WS G++M+ ++ G P++ Sbjct: 202 VWSYGIVMWEVMSYGERPYW 221 >4ZSG-A nrPDB Length = 347 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 70/303 (23%), Positives = 133/303 (43%), Gaps = 46/303 (15%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALK-------MLQDCPKARREVELHWRASQ 113 D+Y++ + +G G G V + T ++ A+K ++ + + RE+++ + + Sbjct: 7 DEYEII-ETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI-LKHFK 64 Query: 114 CPHIVRIVDVYENL--YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 +I+ I D+ Y K + +V++ ++ +L I Q T + + Sbjct: 65 HDNIIAIKDILRPTVPYGEFKSVYVVLDLMES-DLHQIIH--SSQPLTLEHVRYFLYQLL 121 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS-----LTTPCYT 226 ++Y+HS + HRD+KP NLL N LK+ DFG A+ + + +T T Sbjct: 122 RGLKYMHSAQVIHRDLKPSNLLVNE---NCELKIGDFGMARGLCTSPAEHQYFMTEYVAT 178 Query: 227 PYYVAPEV-LGPEKYDKSCDMWSLGVIMYILLCG---YPPFYSNHGLAI--------SPG 274 +Y APE+ L +Y ++ D+WS+G I +L +P H L + SP Sbjct: 179 RWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPA 238 Query: 275 M-----KTRIRMGQYEFPNPE---WSEV----SEEVKMLIRNLLKTEPTQRMTITEFMNH 322 + R+R P + W V + L+ +L+ EP+ R++ + H Sbjct: 239 VIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRH 298 Query: 323 PWI 325 P++ Sbjct: 299 PFL 301 >4EBW-A nrPDB Length = 304 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 47/154 (30%), Positives = 78/154 (50%), Gaps = 16/154 (10%) Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS--IGE 172 PHIV+++ V + I+ME GEL S +Q R ++ AS I+ + + Sbjct: 99 PHIVKLIGVITE-----NPVWIIMELCTLGELRSFLQVR---KYSLDLASLILYAYQLST 150 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCYTPYYV 230 A+ YL S HRD+ N+L +S N +KL DFG ++ E +++ + ++ Sbjct: 151 ALAYLESKRFVHRDIAARNVLVSS---NDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWM 207 Query: 231 APEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPF 263 APE + ++ + D+W GV M+ IL+ G PF Sbjct: 208 APESINFRRFTSASDVWMFGVCMWEILMHGVKPF 241 >5IKW-A nrPDB Length = 310 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 67/260 (25%), Positives = 110/260 (42%), Gaps = 29/260 (11%) Query: 97 DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKC-LLIVMECLDGGELFSRIQDRGD 155 D +RE+ + S +IV +D N + +LI+ME G++ +++ + Sbjct: 53 DLNVCKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQ 112 Query: 156 QAFTEREASEIMKSIGEAIQYLHSIN--IAHRDVKPENLLYTSKRPNAILKLTDFGFA-- 211 FTE E +I EA+ LH I HRD+K EN+L N + L DFG A Sbjct: 113 TGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDG-GNYV--LCDFGSATN 169 Query: 212 ------KETTSHNSLTTPCYTPY-YVAPEVL---GPEKYDKSCDMWSLGVIMYILLCGYP 261 K+ + YT Y APE++ G + D+W+LG ++Y LC + Sbjct: 170 KFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLY-KLCFFT 228 Query: 262 PFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMN 321 + +AI G F P+ S S + LIR +L+ +P R I + Sbjct: 229 LPFGESQVAICDG----------NFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSY 278 Query: 322 HPWIMQSTKVPQTPLHTSRV 341 + + P + ++ S + Sbjct: 279 FAFKFAAADCPVSNINNSSI 298 >4FL3-A nrPDB Length = 635 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 42/173 (24%), Positives = 82/173 (47%), Gaps = 15/173 (8%) Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 P+IVR++ + E + ++VME + G L +Q ++ ++ E++ + + Sbjct: 430 PYIVRMIGICE-----AESWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGM 482 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK----ETTSHNSLTTPCYTPYYV 230 +YL N HRD+ N+L ++ K++DFG +K + + + T + + Sbjct: 483 KYLEESNFVHRDLAARNVLLVTQH---YAKISDFGLSKALRADENYYKAQTHGKWPVKWY 539 Query: 231 APEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMG 282 APE + K+ D+WS GV+M+ G P+ G ++ ++ RMG Sbjct: 540 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMG 592 >4Y93-A nrPDB Length = 446 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 62/251 (24%), Positives = 118/251 (47%), Gaps = 20/251 (7%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYA 129 LG G G V++ R Q A+KM+++ + E + ++V +Y + Sbjct: 196 LGTGQFG-VVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLY-GVCT 253 Query: 130 GRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKP 189 ++ + I+ E + G L + +++ + F ++ E+ K + EA++YL S HRD+ Sbjct: 254 KQRPIFIITEYMANGCLLNYLREMRHR-FQTQQLLEMCKDVCEAMEYLESKQFLHRDLAA 312 Query: 190 ENLLYTSKRPNAILKLTDFGFAKETTS--HNSLTTPCYTPYYVAPEVLGPEKYDKSCDMW 247 N L + ++K++DFG + + S T + + +PEVL K+ D+W Sbjct: 313 RNCLVNDQ---GVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLMYSKFSSKSDIW 369 Query: 248 SLGVIMY-ILLCGYPPF--YSNHGLA--ISPGMKT-RIRMGQ---YEFPNPEWSEVSEE- 297 + GV+M+ I G P+ ++N A I+ G++ R + Y W E ++E Sbjct: 370 AFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLASERVYAIMYSCWHEKADER 429 Query: 298 --VKMLIRNLL 306 K+L+ N+L Sbjct: 430 PTFKILLSNIL 440 >5L6P-A nrPDB Length = 298 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 41/159 (25%), Positives = 79/159 (49%), Gaps = 19/159 (11%) Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 P+I+R+ E + + ++I+ E ++ L S ++ D FT + +++ I + Sbjct: 80 PNIIRL----EGVVTKSRPVMILTEFMENCALDSFLR-LNDGQFTVIQLVGMLRGIAAGM 134 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY------ 228 +YL +N HRD+ N+L S N + K++DFG ++ S P YT Sbjct: 135 KYLSEMNYVHRDLAARNILVNS---NLVCKVSDFGLSRFLEDDPS--DPTYTSSLGGKIP 189 Query: 229 --YVAPEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPFY 264 + APE + K+ + D+WS G++M+ ++ G P++ Sbjct: 190 IRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYW 228 >1K9A-A nrPDB Length = 450 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 49/189 (25%), Positives = 85/189 (44%), Gaps = 12/189 (6%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPH--IVRIVDVYE 125 Q +G G G V+ K A+K +++ A+ + +Q H +V+++ V Sbjct: 199 QTIGKGEFGDVM--LGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIV 256 Query: 126 NLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHR 185 G L IV E + G L ++ RG + + EA++YL N HR Sbjct: 257 EEKGG---LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 313 Query: 186 DVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCD 245 D+ N+L + + + K++DFG KE +S T + APE L +K+ D Sbjct: 314 DLAARNVLVSE---DNVAKVSDFGLTKEASSTQD--TGKLPVKWTAPEALREKKFSTKSD 368 Query: 246 MWSLGVIMY 254 +WS G++++ Sbjct: 369 VWSFGILLW 377 >5OAT-A nrPDB Length = 411 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 68/247 (27%), Positives = 111/247 (44%), Gaps = 55/247 (22%) Query: 104 EVELHWRASQCP---HIVRIVDVYENLY------------AGRK-CLLIVMECLDGGELF 147 E+EL R P +IV I V+ +LY GR L ++M+ D Sbjct: 85 EIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMSLFLLMKRYD----- 139 Query: 148 SRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNA-ILKLT 206 +Q A + R + ++ + E + ++ + IAHRD+K +NLL + P + IL ++ Sbjct: 140 CNLQSFLSTAPSTRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVIS 199 Query: 207 DFG--FAKETTSHNSLTTPCYTPY---------YVAPEVLGPE-------KYDKSCDMWS 248 DFG A +T N L+ P YT Y +APE++ + Y K+ D+W+ Sbjct: 200 DFGCCLADKT---NGLSLP-YTSYEMDKGGNTALMAPEIICQKPGTFSVLNYSKA-DLWA 254 Query: 249 LGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN-PEWSEVSEEVKMLIRNLLK 307 +G I Y + + PFY P + + P P+ EV ++ L+ NLLK Sbjct: 255 VGAIAYEIFNCHNPFY-------GPSRLKNFNYKEGDLPKLPD--EVPTVIQALVANLLK 305 Query: 308 TEPTQRM 314 P +R+ Sbjct: 306 RNPNKRL 312 >2WO6-A nrPDB Length = 382 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 57/213 (26%), Positives = 109/213 (51%), Gaps = 16/213 (7%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD----CPKARREVELHWRASQCP 115 +D Y++ S ++G G G+V++ +++ QE A+K++++ +A+ EV L ++ Sbjct: 53 MDRYEIDS-LIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHD 111 Query: 116 HIVRIVDVY---ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 ++ V+ ++ CL+ M + +L RG R+ ++ M + Sbjct: 112 TEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCT--- 168 Query: 173 AIQYLHS--INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYV 230 A+ +L + ++I H D+KPEN+L + + +AI K+ DFG + + + + +Y Sbjct: 169 ALLFLATPELSIIHCDLKPENILLCNPKRSAI-KIVDFGSSCQLGQR--IYQYIQSRFYR 225 Query: 231 APEVLGPEKYDKSCDMWSLGVIMYILLCGYPPF 263 +PEVL YD + DMWSLG I+ + G P F Sbjct: 226 SPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLF 258 >3EQC-A nrPDB Length = 360 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 61/211 (28%), Positives = 98/211 (46%), Gaps = 21/211 (9%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM--LQDCPKARREVELHWRASQCPHIV 118 DD++ S+ LG G G V ++ +K + A K+ L+ P R ++ R Q H Sbjct: 33 DDFEKISE-LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQI---IRELQVLHEC 88 Query: 119 R---IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 IV Y Y+ + + I ME +DGG L ++ G E+ ++ ++ + + Sbjct: 89 NSPYIVGFYGAFYSDGE-ISICMEHMDGGSLDQVLKKAG--RIPEQILGKVSIAVIKGLT 145 Query: 176 YLHSIN-IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSH--NSLTTPCYTPYYVAP 232 YL + I HRDVKP N+L S+ +KL DFG + + NS T Y++P Sbjct: 146 YLREKHKIMHRDVKPSNILVNSRGE---IKLCDFGVSGQLIDSMANSFVG---TRSYMSP 199 Query: 233 EVLGPEKYDKSCDMWSLGVIMYILLCGYPPF 263 E L Y D+WS+G+ + + G P Sbjct: 200 ERLQGTHYSVQSDIWSMGLSLVEMAVGRYPI 230 >4P5Q-A nrPDB Length = 361 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 41/155 (26%), Positives = 81/155 (52%), Gaps = 13/155 (8%) Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 P+I+R+ E + K ++IV E ++ G L S ++ + D FT + +++ I + Sbjct: 94 PNIIRL----EGVVTKSKPVMIVTEYMENGSLDSFLR-KHDAQFTVIQLVGMLRGIASGM 148 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLTT-PCYTPY-YV 230 +YL + HRD+ N+L S N + K++DFG ++ E + TT P + Sbjct: 149 KYLSDMGYVHRDLAARNILINS---NLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWT 205 Query: 231 APEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPFY 264 +PE + K+ + D+WS G++++ ++ G P++ Sbjct: 206 SPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYW 240 >4C59-A nrPDB Length = 340 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 67/245 (27%), Positives = 105/245 (42%), Gaps = 41/245 (16%) Query: 103 REVELHWRASQCPHIVRIVDVY----ENLYAGRKCLLIVMECLDGG--ELFSRIQDRGDQ 156 +EV + S P+IV+ E G+ L++ E G E +++ RG Sbjct: 73 QEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRG-- 130 Query: 157 AFTEREASEIMKSIGEAIQYLHSIN--IAHRDVKPENLLYTSKRPNAILKLTDFGFAKET 214 + +I A+Q++H I HRD+K ENLL +++ +KL DFG A T Sbjct: 131 PLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQ---GTIKLCDFGSAT-T 186 Query: 215 TSH--------------NSLTTPCYTPYYVAPEVLGPEK---YDKSCDMWSLGVIMYILL 257 SH T TP Y PE++ + D+W+LG I+Y+L Sbjct: 187 ISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLC 246 Query: 258 CGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTIT 317 PF G K RI G+Y P P ++ + LIR +L+ P +R++I Sbjct: 247 FRQHPF--------EDGAKLRIVNGKYSIP-PHDTQYT-VFHSLIRAMLQVNPEERLSIA 296 Query: 318 EFMNH 322 E ++ Sbjct: 297 EVVHQ 301 >1BYG-A nrPDB Length = 278 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 49/189 (25%), Positives = 85/189 (44%), Gaps = 12/189 (6%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPH--IVRIVDVYE 125 Q +G G G V+ K A+K +++ A+ + +Q H +V+++ V Sbjct: 27 QTIGKGEFGDVM--LGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIV 84 Query: 126 NLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHR 185 G L IV E + G L ++ RG + + EA++YL N HR Sbjct: 85 EEKGG---LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 141 Query: 186 DVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCD 245 D+ N+L + + + K++DFG KE +S T + APE L +K+ D Sbjct: 142 DLAARNVLVSE---DNVAKVSDFGLTKEASSTQD--TGKLPVKWTAPEALREKKFSTKSD 196 Query: 246 MWSLGVIMY 254 +WS G++++ Sbjct: 197 VWSFGILLW 205 >5G6V-A nrPDB Length = 324 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 62/206 (30%), Positives = 88/206 (42%), Gaps = 26/206 (12%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKML-----QDCP-KARREVELHWRASQCPHIVRIVDV 123 LG G V + +K T ALK + + P A REV L + + +IV + D+ Sbjct: 10 LGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSL-LKDLKHANIVTLHDI 68 Query: 124 YENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIA 183 K L +V E LD +L + D G+ + + + Y H + Sbjct: 69 IHT----EKSLTLVFEYLDK-DLKQYLDDCGN-IINMHNVKLFLFQLLRGLAYCHRQKVL 122 Query: 184 HRDVKPENLLYTSKRPNAILKLTDFGFAKET-----TSHNSLTTPCYTPYYVAPEVL-GP 237 HRD+KP+NLL + LKL DFG A+ T N + T Y P P++L G Sbjct: 123 HRDLKPQNLLINERGE---LKLADFGLARAKSIPTKTYDNEVVTLWYRP----PDILLGS 175 Query: 238 EKYDKSCDMWSLGVIMYILLCGYPPF 263 Y DMW +G I Y + G P F Sbjct: 176 TDYSTQIDMWGVGCIFYEMATGRPLF 201 >1S9I-A nrPDB Length = 354 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 67/217 (30%), Positives = 97/217 (44%), Gaps = 33/217 (15%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM--LQDCPKARREVELHWRASQCPHIV 118 DD++ S+ LG G G V ++ ++ + A K+ L+ P R ++ R Q H Sbjct: 16 DDFERISE-LGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQI---IRELQVLHEC 71 Query: 119 R---IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTE--REASEIMKSIGEA 173 IV Y Y+ + + I ME +DGG L DQ E R EI+ + A Sbjct: 72 NSPYIVGFYGAFYSDGE-ISICMEHMDGGSL--------DQVLKEAKRIPEEILGKVSIA 122 Query: 174 I----QYLHSIN-IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSH--NSLTTPCYT 226 + YL + I HRDVKP N+L S+ +KL DFG + + NS T Sbjct: 123 VLRGLAYLREKHQIMHRDVKPSNILVNSR---GEIKLCDFGVSGQLIDSMANSFVG---T 176 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPF 263 Y+APE L Y D+WS+G+ + L G P Sbjct: 177 RSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPI 213 >5VD3-A nrPDB Length = 311 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 65/266 (24%), Positives = 113/266 (42%), Gaps = 28/266 (10%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQCPHIVRIVD 122 LG G G+V ++ +K +A+K +D + EV H + Q P VR+ Sbjct: 65 LGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQ 124 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182 +E +L + L G L + G + E + ++ A+ +LHS + Sbjct: 125 AWEE-----GGILYLQTELCGPSLQQHCEAWG-ASLPEAQVWGYLRDTLLALAHLHSQGL 178 Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDK 242 H DVKP N+ P KL DFG E + + P Y+APE+L Y Sbjct: 179 VHLDVKPANIFLG---PRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELL-QGSYGT 234 Query: 243 SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSE-VSEEVKML 301 + D++SLG+ + + C + G ++R G + PE++ +S E++ + Sbjct: 235 AADVFSLGLTILEVACNMELPHGGEGW-------QQLRQG---YLPPEFTAGLSSELRSV 284 Query: 302 IRNLLKTEPTQRMTITEFMNHPWIMQ 327 + +L+ +P R T + P + Q Sbjct: 285 LVMMLEPDPKLRATAEALLALPVLRQ 310 >6GU6-A nrPDB Length = 302 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 75/301 (24%), Positives = 129/301 (42%), Gaps = 49/301 (16%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------QDCPK-ARREVELHWRAS 112 ++DY ++ G G G V + +K T + A+K + + P A RE+ L + Sbjct: 6 MEDYTKIEKI-GEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISL-LKEL 63 Query: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRI--QDRGDQAFTEREASEIMKSI 170 + P+IV + DV + R L+ +D + I D + + +I+ Sbjct: 64 RHPNIVSLQDVL--MQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQIL--- 118 Query: 171 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYY 229 + I + HS + HRD+KP+NLL K +KL DFG A+ T T +Y Sbjct: 119 -QGIVFCHSRRVLHRDLKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHEVVTLWY 174 Query: 230 VAPEV-LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL---------------AISP 273 +PEV LG +Y D+WS+G I L P F+ + + + P Sbjct: 175 RSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP 234 Query: 274 GMKTRIRMGQYEFPNPEW--SEVSEEVKMLIRN-------LLKTEPTQRMTITEFMNHPW 324 +++ + Y+ P+W ++ VK L N +L +P +R++ +NHP+ Sbjct: 235 EVES---LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 291 Query: 325 I 325 Sbjct: 292 F 292 >4AN9-A nrPDB Length = 301 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 72/277 (25%), Positives = 123/277 (44%), Gaps = 29/277 (10%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM--LQDCPKARREVELHWRASQCPHIV 118 DD++ S+ LG G G V ++ +K + A K+ L+ P R ++ R Q H Sbjct: 9 DDFEKISE-LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQI---IRELQVLHEC 64 Query: 119 R---IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 IV Y Y+ + + I ME +DGG L ++ G E+ ++ ++ + + Sbjct: 65 NSPYIVGFYGAFYSDGE-ISICMEHMDGGSLDQVLKKAG--RIPEQILGKVSIAVIKGLT 121 Query: 176 YLHSIN-IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV 234 YL + I HRDVKP N+L S+ +KL DFG + + + T Y++PE Sbjct: 122 YLREKHKIMHRDVKPSNILVNSRGE---IKLCDFGVSGQLIDEMA-NEFVGTRSYMSPER 177 Query: 235 LGPEKYDKSCDMWSLGVIMYILLCG---YPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW 291 L Y D+WS+G+ + + G PP +AI + + + P+ + Sbjct: 178 LQGTHYSVQSDIWSMGLSLVEMAVGRYPRPP------MAIFELLDYIVNEPPPKLPSAVF 231 Query: 292 SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328 S E + + L P +R + + M H +I +S Sbjct: 232 ---SLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRS 265 >5XVU-A nrPDB Length = 332 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 35/111 (31%), Positives = 57/111 (51%), Gaps = 3/111 (2%) Query: 158 FTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSH 217 FT+++ + I +A+ Y HS I HRDVKP N++ + N ++L +G A+ Sbjct: 122 FTDKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHE--NRQIRLISWGLAEFYHPG 179 Query: 218 NSLTTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH 267 + YY PE+L + YD S D+WSLG ++ ++ PF+ H Sbjct: 180 QEYNVRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGH 230 >2R2P-A nrPDB Length = 295 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 41/155 (26%), Positives = 80/155 (51%), Gaps = 13/155 (8%) Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 P+I+ + E + K ++IV E ++ G L + ++ + D FT + +++ I + Sbjct: 83 PNIIHL----EGVVTKSKPVMIVTEYMENGSLDTFLK-KNDGQFTVIQLVGMLRGISAGM 137 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLTT-PCYTPY-YV 230 +YL + HRD+ N+L S N + K++DFG ++ E + TT P + Sbjct: 138 KYLSDMGYVHRDLAARNILINS---NLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWT 194 Query: 231 APEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPFY 264 APE + K+ + D+WS G++M+ ++ G P++ Sbjct: 195 APEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYW 229 >4CRL-A nrPDB Length = 406 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 37/105 (35%), Positives = 55/105 (52%), Gaps = 6/105 (5%) Query: 166 IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPN-AILKLTDFGFAKETTS----HNSL 220 ++ I + I YLH+ + HRD+KP N+L + P +K+ D GFA+ S L Sbjct: 134 LLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADL 193 Query: 221 TTPCYTPYYVAPE-VLGPEKYDKSCDMWSLGVIMYILLCGYPPFY 264 T +Y APE +LG Y K+ D+W++G I LL P F+ Sbjct: 194 DPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFH 238 >5C26-A nrPDB Length = 299 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 42/173 (24%), Positives = 82/173 (47%), Gaps = 15/173 (8%) Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 P+IVR++ + E + ++VME + G L +Q ++ ++ E++ + + Sbjct: 88 PYIVRMIGICE-----AESWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGM 140 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK----ETTSHNSLTTPCYTPYYV 230 +YL N HRD+ N+L ++ K++DFG +K + + + T + + Sbjct: 141 KYLEESNFVHRDLAARNVLLVTQH---YAKISDFGLSKALRADENYYKAQTHGKWPVKWY 197 Query: 231 APEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMG 282 APE + K+ D+WS GV+M+ G P+ G ++ ++ RMG Sbjct: 198 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMG 250 >4M7I-A nrPDB Length = 299 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 41/124 (33%), Positives = 62/124 (50%), Gaps = 21/124 (16%) Query: 154 GDQAFTEREAS---EIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGF 210 G ERE S I I EA+++LHS + HRD+KP N+ +T + ++K+ DFG Sbjct: 108 GRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTM---DDVVKVGDFGL 164 Query: 211 A----KETTSHNSLT-TPCY--------TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILL 257 ++ LT P Y T Y++PE + Y D++SLG+I++ LL Sbjct: 165 VTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELL 224 Query: 258 CGYP 261 YP Sbjct: 225 --YP 226 >2J0K-A nrPDB Length = 656 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 46/154 (29%), Positives = 77/154 (50%), Gaps = 16/154 (10%) Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS--IGE 172 PHIV+++ V + I+ME GEL S +Q R F+ AS I+ + + Sbjct: 451 PHIVKLIGV-----ITENPVWIIMELCTLGELRSFLQVR---KFSLDLASLILYAYQLST 502 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCYTPYYV 230 A+ YL S HRD+ N+L ++ +KL DFG ++ E +++ + ++ Sbjct: 503 ALAYLESKRFVHRDIAARNVLVSA---TDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWM 559 Query: 231 APEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPF 263 APE + ++ + D+W GV M+ IL+ G PF Sbjct: 560 APESINFRRFTSASDVWMFGVCMWEILMHGVKPF 593 >2PMN-X nrPDB Length = 348 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 64/273 (23%), Positives = 113/273 (41%), Gaps = 40/273 (14%) Query: 82 FNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECL 141 F K +K ++K D K ++ + C I+ Y+ +Y I+ E + Sbjct: 73 FTKSNNDKISIKSKYDDFKNELQIITDIKNEYCLTCEGIITNYDEVY-------IIYEYM 125 Query: 142 DGGEL-----FSRIQDRGDQAFTEREASE-IMKSIGEAIQYLHS-INIAHRDVKPENLLY 194 + + + + D+ F + + I+KS+ + Y+H+ NI HRDVKP N+L Sbjct: 126 ENDSILKFDEYFFVLDKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILM 185 Query: 195 TSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPE-KYDKS-CDMWSLGVI 252 N +KL+DFG E + T ++ PE E Y+ + D+WSLG+ Sbjct: 186 D---KNGRVKLSDFG-ESEYMVDKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGIC 241 Query: 253 MYILLCGYPPFYSNHGLAIS-PGMKTRIRMGQYEFP---------------NPEWSEVSE 296 +Y++ PF L IS + IR E+P + +S Sbjct: 242 LYVMFYNVVPF----SLKISLVELFNNIRTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSN 297 Query: 297 EVKMLIRNLLKTEPTQRMTITEFMNHPWIMQST 329 E ++ L+ P +R+T + + H W+ + Sbjct: 298 EDIDFLKLFLRKNPAERITSEDALKHEWLADTN 330 >3DKO-A nrPDB Length = 318 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 40/156 (25%), Positives = 80/156 (51%), Gaps = 13/156 (8%) Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 P++V + E + K ++IV+E ++ G L + ++ + D FT + +++ I + Sbjct: 104 PNVVHL----EGVVTRGKPVMIVIEFMENGALDAFLR-KHDGQFTVIQLVGMLRGIAAGM 158 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK---ETTSHNSLTTPCYTPY-YV 230 +YL + HRD+ N+L S N + K++DFG ++ + TT P + Sbjct: 159 RYLADMGYVHRDLAARNILVNS---NLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWT 215 Query: 231 APEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPFYS 265 APE + K+ + D+WS G++M+ ++ G P++ Sbjct: 216 APEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWD 251 >6HV0-A nrPDB Length = 416 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 72/314 (22%), Positives = 141/314 (44%), Gaps = 26/314 (8%) Query: 69 VLGLGINGKVL--QIFNKRTQEKFALKMLQDCPK-ARREVELHWRASQCPHIVRIVDVYE 125 VLG G G ++ +F+ R + ++L +C A REV+L + + P+++R Y Sbjct: 15 VLGHGAEGTIVYRGMFDNR--DVAVKRILPECFSFADREVQLLRESDEHPNVIR----YF 68 Query: 126 NLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHR 185 R+ I +E L L ++ + D A E +++ + +LHS+NI HR Sbjct: 69 CTEKDRQFQYIAIE-LCAATLQEYVEQK-DFAHLGLEPITLLQQTTSGLAHLHSLNIVHR 126 Query: 186 DVKPENLLYTSKRPNAILK--LTDFGFAKE-TTSHNSLTTPCYTP---YYVAPEVLGPEK 239 D+KP N+L + + +K ++DFG K+ +S + P ++APE+L + Sbjct: 127 DLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDC 186 Query: 240 YDK---SCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 295 + + D++S G + Y ++ G PF G ++ + + +PE E Sbjct: 187 KENPTYTVDIFSAGCVFYYVISEGSHPF----GKSLQRQANILLGACSLDCLHPEKHE-D 241 Query: 296 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEE 355 + LI ++ +P +R + + HP+ K Q S ++++ VK+ Sbjct: 242 VIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQL 301 Query: 356 MTSALATMRVDYEQ 369 A +++D+ + Sbjct: 302 ERGGRAVVKMDWRE 315 >3QD2-B nrPDB Length = 332 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 34/108 (31%), Positives = 56/108 (51%), Gaps = 16/108 (14%) Query: 166 IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFA----KETTSHNSLT 221 I I EA+++LHS + HRD+KP N+ +T + ++K+ DFG ++ LT Sbjct: 169 IFIQIAEAVEFLHSKGLMHRDLKPSNIFFTM---DDVVKVGDFGLVTAMDQDEEEQTVLT 225 Query: 222 -TPCY--------TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGY 260 P Y T Y++PE + Y D++SLG+I++ LL + Sbjct: 226 PMPAYATHTGQVGTKLYMSPEQIHGNNYSHKVDIFSLGLILFELLYSF 273 >2W1I-A nrPDB Length = 326 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 60/206 (29%), Positives = 96/206 (46%), Gaps = 26/206 (12%) Query: 68 QVLGLGINGKVLQI----FNKRTQEKFALKMLQDCPKAR-----REVELHWRASQCPHIV 118 Q LG G G V T E A+K LQ + RE+E+ ++ Q +IV Sbjct: 47 QQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEI-LKSLQHDNIV 105 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQ---DRGDQAFTEREASEIMKSIGEAIQ 175 + V + AGR+ L ++ME L G L +Q +R D + S+I K ++ Sbjct: 106 KYKGVCYS--AGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICK----GME 159 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK---ETTSHNSLTTPCYTP-YYVA 231 YL + HRD+ N+L ++ +K+ DFG K + + + P +P ++ A Sbjct: 160 YLGTKRYIHRDLATRNILVENENR---VKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYA 216 Query: 232 PEVLGPEKYDKSCDMWSLGVIMYILL 257 PE L K+ + D+WS GV++Y L Sbjct: 217 PESLTESKFSVASDVWSFGVVLYELF 242 >3IO7-A nrPDB Length = 313 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 60/206 (29%), Positives = 96/206 (46%), Gaps = 26/206 (12%) Query: 68 QVLGLGINGKVLQI----FNKRTQEKFALKMLQDCPKAR-----REVELHWRASQCPHIV 118 Q LG G G V T E A+K LQ + RE+E+ ++ Q +IV Sbjct: 34 QQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEI-LKSLQHDNIV 92 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQ---DRGDQAFTEREASEIMKSIGEAIQ 175 + V + AGR+ L ++ME L G L +Q +R D + S+I K ++ Sbjct: 93 KYKGVCYS--AGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICK----GME 146 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK---ETTSHNSLTTPCYTP-YYVA 231 YL + HRD+ N+L ++ +K+ DFG K + + + P +P ++ A Sbjct: 147 YLGTKRYIHRDLATRNILVENENR---VKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYA 203 Query: 232 PEVLGPEKYDKSCDMWSLGVIMYILL 257 PE L K+ + D+WS GV++Y L Sbjct: 204 PESLTESKFSVASDVWSFGVVLYELF 229 >4HVI-A nrPDB Length = 314 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 62/207 (29%), Positives = 92/207 (44%), Gaps = 21/207 (10%) Query: 64 KVTSQVLGLGINGKV----LQIFNKRTQEKFALKMLQDC-PKARREVELHWRASQCPHIV 118 K SQ LG G G V T A+K LQ P +R+ + + + H Sbjct: 13 KYISQ-LGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSD 71 Query: 119 RIVDVYENLYA-GRKCLLIVMECLDGG---ELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 IV Y GR+ L +VME L G + R + R D + +S+I K + Sbjct: 72 FIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICK----GM 127 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE---TTSHNSLTTPCYTP-YYV 230 +YL S HRD+ N+L S+ A +K+ DFG AK + + P +P ++ Sbjct: 128 EYLGSRRCVHRDLAARNILVESE---AHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWY 184 Query: 231 APEVLGPEKYDKSCDMWSLGVIMYILL 257 APE L + + D+WS GV++Y L Sbjct: 185 APESLSDNIFSRQSDVWSFGVVLYELF 211 >5EG3-A nrPDB Length = 334 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 47/182 (25%), Positives = 82/182 (45%), Gaps = 14/182 (7%) Query: 143 GGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAI 202 G EL I ++ T ++ + ++YL S HRD+ N+L T N + Sbjct: 139 GMELSPDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE---NNV 195 Query: 203 LKLTDFGFAKETTSHNSL--TTPCYTPY-YVAPEVLGPEKYDKSCDMWSLGVIMY-ILLC 258 +K+ DFG A++ + + TT P ++APE L Y D+WS GV+M+ I Sbjct: 196 MKIADFGLARDINNIDFFKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTL 255 Query: 259 GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITE 318 G P+ G+ + K + + P + + E+ M++R+ P+QR T + Sbjct: 256 GGSPY---PGIPVEELFKLLKEGHRMDKP----ANCTNELYMMMRDCWHAVPSQRPTFKQ 308 Query: 319 FM 320 + Sbjct: 309 LV 310 >3BEA-A nrPDB Length = 333 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 67/305 (21%), Positives = 124/305 (40%), Gaps = 38/305 (12%) Query: 32 PAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFA 91 P Q P +FP+ +++ G + A V + GLG VL++ A Sbjct: 32 PTQLPYNEKWEFPRNNLQFGKTLGAGAF--GKVVEATAFGLGKEDAVLKV---------A 80 Query: 92 LKMLQDCPKARREVELHWRASQCPHIVR---IVDVYENLYAGRKCLLIVMECLDGGEL-F 147 +KML+ A + L H+ + IV++ G L+I C G L F Sbjct: 81 VKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNF 140 Query: 148 SRIQDR----------GDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSK 197 R + R + + R+ + + + +L S N HRDV N+L T+ Sbjct: 141 LRRKSRVLETDPAFAIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNG 200 Query: 198 RPNAILKLTDFGFAKETTSHNSLTTPCYTPY---YVAPEVLGPEKYDKSCDMWSLGVIMY 254 + K+ DFG A++ + ++ ++APE + Y D+WS G++++ Sbjct: 201 H---VAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLW 257 Query: 255 -ILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQR 313 I G P+ G+ ++ ++ G Y+ P ++ + + +++ EPT R Sbjct: 258 EIFSLGLNPY---PGILVNSKFYKLVKDG-YQMAQPAFA--PKNIYSIMQACWALEPTHR 311 Query: 314 MTITE 318 T + Sbjct: 312 PTFQQ 316 >4XI2-A nrPDB Length = 446 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 65/255 (25%), Positives = 119/255 (46%), Gaps = 28/255 (10%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYA 129 LG G G V++ R Q A+KM+++ + E + ++V +Y + Sbjct: 195 LGTGQFG-VVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHEKLVQLY-GVCT 252 Query: 130 GRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKP 189 ++ + I+ E + G L + +++ F ++ E+ K + EA++YL S HRD+ Sbjct: 253 KQRPIFIITEYMANGCLLNYLREM-RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAA 311 Query: 190 ENLLYTSKRPNAILKLTDFGFAK-----ETTSHNSLTTPC-YTPYYVAPEVLGPEKYDKS 243 N L + ++K++DFG ++ E TS P ++P PEVL K+ Sbjct: 312 RNCLVNDQ---GVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSP----PEVLMYSKFSSK 364 Query: 244 CDMWSLGVIMY-ILLCGYPPF--YSNHGLA--ISPGMKT-RIRMGQ---YEFPNPEWSEV 294 D+W+ GV+M+ I G P+ ++N A I+ G++ R + Y W E Sbjct: 365 SDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERVYTIMYSCWHEK 424 Query: 295 SEE---VKMLIRNLL 306 ++E K+L+ N+L Sbjct: 425 ADERPSFKILLSNIL 439 >4F0G-A nrPDB Length = 287 Score = 58.2 bits (139), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 39/134 (29%), Positives = 69/134 (51%), Gaps = 9/134 (6%) Query: 136 IVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN--IAHRDVKPENLL 193 +VME + G+L+ R+ D+ +M I I+Y+ + N I HRD++ N+ Sbjct: 98 MVMEFVPCGDLYHRLLDKA-HPIKWSVKLRLMLDIALGIEYMQNQNPPIVHRDLRSPNIF 156 Query: 194 YTSKRPNA--ILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEK--YDKSCDMWSL 249 S NA K+ DFG ++++ +S++ ++APE +G E+ Y + D +S Sbjct: 157 LQSLDENAPVCAKVADFGLSQQSV--HSVSGLLGNFQWMAPETIGAEEESYTEKADTYSF 214 Query: 250 GVIMYILLCGYPPF 263 +I+Y +L G PF Sbjct: 215 AMILYTILTGEGPF 228 >4F9B-A nrPDB Length = 361 Score = 57.8 bits (138), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 45/136 (33%), Positives = 58/136 (42%), Gaps = 36/136 (26%) Query: 161 REASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFA--------- 211 +E E M ++ +A++ +H I HRDVKP N LY + L DFG A Sbjct: 117 QEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKK--YALVDFGLAQGTHDTKIE 174 Query: 212 ----------KETTSHNSLTTPCY-----------TPYYVAPEVLG--PEKYDKSCDMWS 248 +E S N + C TP + APEVL P + + DMWS Sbjct: 175 LLKFVQSEAQQERCSQNKCSI-CLSRRQQVAPRAGTPGFRAPEVLTKCPNQ-TTAIDMWS 232 Query: 249 LGVIMYILLCGYPPFY 264 GVI LL G PFY Sbjct: 233 AGVIFLSLLSGRYPFY 248 >3OMV-A nrPDB Length = 307 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 35/142 (24%), Positives = 67/142 (47%), Gaps = 10/142 (7%) Query: 128 YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDV 187 Y + L IV + +G L+ + + + F + +I + + + YLH+ NI HRD+ Sbjct: 100 YMTKDNLAIVTQWCEGSSLYKHLHVQ-ETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDM 158 Query: 188 KPENLLYTSKRPNAILKLTDFGFA---KETTSHNSLTTPCYTPYYVAPEVLGPEK---YD 241 K N+ +K+ DFG A + + P + ++APEV+ + + Sbjct: 159 KSNNIFL---HEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFS 215 Query: 242 KSCDMWSLGVIMYILLCGYPPF 263 D++S G+++Y L+ G P+ Sbjct: 216 FQSDVYSYGIVLYELMTGELPY 237 >6CTH-A nrPDB Length = 309 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 49/152 (32%), Positives = 68/152 (44%), Gaps = 13/152 (8%) Query: 131 RKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN---IAHRDV 187 R L++V E + G L S I +G T I+K + A+ YLH + HRD+ Sbjct: 84 RGELMLVYEFMANGSLDSHIF-KGKSLLTWEVRYRIVKDLASALLYLHEEGDHCVLHRDI 142 Query: 188 KPENLLYTSKRPNAILKLTDFGFAKETTSHNSL--TTPCYTPYYVAPEVLGPEKYDKSCD 245 K N++ S NA KL DFG A+ L T T Y+APE L K K D Sbjct: 143 KTSNIMLDSS-FNA--KLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLSSGKASKESD 199 Query: 246 MWSLGVIMYILLCGY----PPFYSNHGLAISP 273 ++S GV+ + G P F + L + P Sbjct: 200 VYSFGVVALEIASGRRSIEPKFEESEALLLVP 231 >2PSQ-A nrPDB Length = 370 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 43/170 (25%), Positives = 78/170 (45%), Gaps = 14/170 (8%) Query: 155 DQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET 214 ++ T ++ + ++YL S HRD+ N+L T N ++K+ DFG A++ Sbjct: 197 EEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE---NNVMKIADFGLARDI 253 Query: 215 TS--HNSLTTPCYTPY-YVAPEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPFYSNHGLA 270 + + TT P ++APE L Y D+WS GV+M+ I G P+ G+ Sbjct: 254 NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY---PGIP 310 Query: 271 ISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM 320 + K + + P + + E+ M++R+ P+QR T + + Sbjct: 311 VEELFKLLKEGHRMDKP----ANCTNELYMMMRDCWHAVPSQRPTFKQLV 356 >4CSV-A nrPDB Length = 275 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 48/211 (22%), Positives = 87/211 (41%), Gaps = 30/211 (14%) Query: 134 LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL 193 + I+ E + G L ++D + ++ + + YL S N HRD+ N L Sbjct: 82 IYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAYLESQNFIHRDLAARNCL 141 Query: 194 YTSKRPNAILKLTDFGFAK-----ETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWS 248 N ++K+ DFG A+ E T+ P + APE + ++ D+W+ Sbjct: 142 VGE---NNVVKVADFGLARLINEDEYTARAGAKFPI---KWTAPEAISYNRFSIKSDVWA 195 Query: 249 LGVIMY-ILLCGYPPFYSNHGLAISPGMKTRIRMGQ----YEFPNPEWSEVSEEVKMLIR 303 G++++ I G P+ PGM + Q Y P P+ EE+ L+ Sbjct: 196 FGILLWEIFTYGQVPY---------PGMSGSEVIEQVERGYRMPRPQ--GCPEEIYELML 244 Query: 304 NLLKTEPTQRMTITEFMNHPWIMQSTKVPQT 334 P +R T E ++ +++ +P+T Sbjct: 245 QCWNKSPEERPTFAETLH---ALETMFLPET 272 >2PZI-A nrPDB Length = 681 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 67/237 (28%), Positives = 99/237 (41%), Gaps = 44/237 (18%) Query: 115 PHIVRIVDVYENL-YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEA 173 P IV+I + E+ G IVME + GG+ R + Q EA + I A Sbjct: 139 PSIVQIFNFVEHTDRHGDPVGYIVMEYV-GGQSLKRSKG---QKLPVAEAIAYLLEILPA 194 Query: 174 IQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPE 233 + YLHSI + + D+KPEN++ T ++ LKL D G S L TP + APE Sbjct: 195 LSYLHSIGLVYNDLKPENIMLTEEQ----LKLIDLGAVSRINSFGYLYG---TPGFQAPE 247 Query: 234 VL--GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW 291 ++ GP + D++++G + L P R G+Y PE Sbjct: 248 IVRTGPT---VATDIYTVGRTLAALTLDLP-----------------TRNGRYVDGLPED 287 Query: 292 SEV---SEEVKMLIRNLLKTEPTQRMTITEFMN-------HPWIMQSTKVPQTPLHT 338 V + L+R + +P QR T E M+ + Q T VP+ L T Sbjct: 288 DPVLKTYDSYGRLLRRAIDPDPRQRFTTAEEMSAQLTGVLREVVAQDTGVPRPGLST 344 >2OGV-A nrPDB Length = 317 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 67/301 (22%), Positives = 123/301 (40%), Gaps = 34/301 (11%) Query: 32 PAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFA 91 P Q P +FP+ +++ G + A V + GLG VL++ A Sbjct: 24 PTQLPYNEKWEFPRNNLQFGKTLGAGAF--GKVVEATAFGLGKEDAVLKV---------A 72 Query: 92 LKMLQDCPKARREVELHWRASQCPHIVR---IVDVYENLYAGRKCLLIVMECLDGGEL-F 147 +KML+ A + L H+ + IV++ G L+I C G L F Sbjct: 73 VKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNF 132 Query: 148 SRIQDRGD------QAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNA 201 R + D + R+ + + + +L S N HRDV N+L T+ Sbjct: 133 LRRKAEADLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGH--- 189 Query: 202 ILKLTDFGFAKETTSHNSLTTPCYTPY---YVAPEVLGPEKYDKSCDMWSLGVIMY-ILL 257 + K+ DFG A++ + ++ ++APE + Y D+WS G++++ I Sbjct: 190 VAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFS 249 Query: 258 CGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTIT 317 G P+ G+ ++ ++ G Y+ P ++ + + +++ EPT R T Sbjct: 250 LGLNPY---PGILVNSKFYKLVKDG-YQMAQPAFA--PKNIYSIMQACWALEPTHRPTFQ 303 Query: 318 E 318 + Sbjct: 304 Q 304 >6E4F-A nrPDB Length = 290 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 65/255 (25%), Positives = 119/255 (46%), Gaps = 28/255 (10%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYA 129 LG G G V++ R Q A+KM+++ + E + ++V +Y + Sbjct: 39 LGTGQFG-VVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLY-GVCT 96 Query: 130 GRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKP 189 ++ + I+ E + G L + +++ F ++ E+ K + EA++YL S HRD+ Sbjct: 97 KQRPIFIITEYMANGCLLNYLREM-RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAA 155 Query: 190 ENLLYTSKRPNAILKLTDFGFAK-----ETTSHNSLTTPC-YTPYYVAPEVLGPEKYDKS 243 N L + ++K++DFG ++ E TS P ++P PEVL K+ Sbjct: 156 RNCLVNDQ---GVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSP----PEVLMYSKFSSK 208 Query: 244 CDMWSLGVIMY-ILLCGYPPF--YSNHGLA--ISPGMKT-RIRMGQ---YEFPNPEWSEV 294 D+W+ GV+M+ I G P+ ++N A I+ G++ R + Y W E Sbjct: 209 SDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEK 268 Query: 295 SEE---VKMLIRNLL 306 ++E K+L+ N+L Sbjct: 269 ADERPTFKILLSNIL 283 >3PG1-A nrPDB Length = 362 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 66/289 (22%), Positives = 119/289 (41%), Gaps = 34/289 (11%) Query: 65 VTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD---CPKARREVELHWRASQCPHIVRIV 121 V + V GI + ++FN + + + +L D C + RE+ L P+I+ + Sbjct: 38 VCAGVDSEGIPVAIKRVFNTVSDGR-TVNILSDSFLCKRVLREIRL-LNHFHHPNILGLR 95 Query: 122 DVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN 181 D++ + L ++ L +L I D+ + + M I + LH Sbjct: 96 DIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQR-IVISPQHIQYFMYHILLGLHVLHEAG 154 Query: 182 IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPE-VLGPEKY 240 + HRD+ P N+L N + + DF A+E T+ + T +Y APE V+ + + Sbjct: 155 VVHRDLHPGNILLAD---NNDITICDFNLAREDTADANKTHYVTHRWYRAPELVMQFKGF 211 Query: 241 DKSCDMWSLGVIMYIL-----LCGYPPFYSNHGLAI---------------SPGMKTRIR 280 K DMWS G +M + L FY+ + SP + +R Sbjct: 212 TKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVVMFSSPSARDYLR 271 Query: 281 MGQYEFPNPEWSEV---SEEVKM-LIRNLLKTEPTQRMTITEFMNHPWI 325 P W+ V ++ V + LI +L+ P +R++ + + HP+ Sbjct: 272 NSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHPYF 320 >4H1J-A nrPDB Length = 293 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 56/211 (26%), Positives = 96/211 (45%), Gaps = 20/211 (9%) Query: 65 VTSQVLGLGINGKVLQ-IFNKRTQEKF--ALKMLQ-DCPKARREVELH----WRASQCPH 116 V +++LG G G+V + ++ EK A+K + DC +E + + PH Sbjct: 27 VLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPH 86 Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 IV+++ + E + I+ME GEL ++ R + I +A+ Y Sbjct: 87 IVKLIGIIE-----EEPTWIIMELYPYGELGHYLE-RNKNSLKVLTLVLYSLQICKAMAY 140 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCYTPYYVAPEV 234 L SIN HRD+ N+L S P + KL DFG ++ E + + +++PE Sbjct: 141 LESINCVHRDIAVRNILVAS--PECV-KLGDFGLSRYIEDEDYYKASVTRLPIKWMSPES 197 Query: 235 LGPEKYDKSCDMWSLGVIMY-ILLCGYPPFY 264 + ++ + D+W V M+ IL G PF+ Sbjct: 198 INFRRFTTASDVWMFAVCMWEILSFGKQPFF 228 >5X5O-A nrPDB Length = 310 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 38/142 (26%), Positives = 67/142 (47%), Gaps = 11/142 (7%) Query: 136 IVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS---INIAHRDVKPENL 192 IV E G L+ I + + + + YLH + + HRD+K N+ Sbjct: 81 IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNV 140 Query: 193 LYTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLG 250 + + + +LK+ DFG ++ T+H SL T ++APEV+ ++CD +S G Sbjct: 141 VIAA---DGVLKICDFGASRFHNHTTHMSLVG---TFPWMAPEVIQSLPVSETCDTYSYG 194 Query: 251 VIMYILLCGYPPFYSNHGLAIS 272 V+++ +L PF GL ++ Sbjct: 195 VVLWEMLTREVPFKGLEGLQVA 216 >3GC0-A nrPDB Length = 329 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 57/215 (26%), Positives = 94/215 (43%), Gaps = 20/215 (9%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------QDCP-KARREVELHWRAS 112 ID Y+ ++ LG G G+V + + T E A+K + + P A REV L + Sbjct: 33 IDRYRRITK-LGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSL-LKEL 90 Query: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 Q +I+ + V + + L ++ E + + D+ + R + + Sbjct: 91 QHRNIIELKSVIHHNHR----LHLIFEYAEND--LKKYMDKNPDV-SMRVIKSFLYQLIN 143 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNA--ILKLTDFGFAKE-TTSHNSLTTPCYTPYY 229 + + HS HRD+KP+NLL + + +LK+ DFG A+ T T +Y Sbjct: 144 GVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWY 203 Query: 230 VAPEV-LGPEKYDKSCDMWSLGVIMYILLCGYPPF 263 PE+ LG Y S D+WS+ I +L P F Sbjct: 204 RPPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLF 238 >2QKW-B nrPDB Length = 321 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 41/150 (27%), Positives = 73/150 (48%), Gaps = 14/150 (9%) Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRI--QDRGDQAFTEREASEIMKSIGE 172 PH+V ++ + R ++++ + ++ G L + D + + + EI Sbjct: 95 PHLVSLIGFCDE----RNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAAR 150 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT----SHNSLTTPCYTPY 228 + YLH+ I HRDVK N+L N + K+TDFG +K+ T +H S T T Sbjct: 151 GLHYLHTRAIIHRDVKSINILLD---ENFVPKITDFGISKKGTELDQTHLS-TVVKGTLG 206 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMYILLC 258 Y+ PE + + D++S GV+++ +LC Sbjct: 207 YIDPEYFIKGRLTEKSDVYSFGVVLFEVLC 236 >4AT3-A nrPDB Length = 299 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 59/230 (25%), Positives = 99/230 (43%), Gaps = 43/230 (18%) Query: 65 VTSQVLGLGINGKVL--QIFN---KRTQEKFALKMLQDCPKARREVELHWRAS-----QC 114 V + LG G GKV + +N ++ + A+K L+D R+ + H A Q Sbjct: 16 VLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARK-DFHREAELLTNLQH 74 Query: 115 PHIVRIVDVYENLYAGRKC-----LLIVMECLDGGELFSRIQDRGDQA-----------F 158 HIV+ V C L++V E + G+L ++ G A Sbjct: 75 EHIVKFYGV---------CVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTEL 125 Query: 159 TEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN 218 T+ + I + I + YL S + HRD+ N L N ++K+ DFG +++ S + Sbjct: 126 TQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGE---NLLVKIGDFGMSRDVYSTD 182 Query: 219 SLTTPCYTPY---YVAPEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPFY 264 +T ++ PE + K+ D+WSLGV+++ I G P+Y Sbjct: 183 YYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWY 232 >4E20-A nrPDB Length = 290 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 80/285 (28%), Positives = 127/285 (44%), Gaps = 38/285 (13%) Query: 70 LGLGINGKV-LQIF---NKRTQEKFALKMLQD-C-PKAR----REVELHWRASQCPHIVR 119 LG G GKV L + N T E A+K L++ C P+ R RE+E+ R HIV+ Sbjct: 16 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEI-LRTLYHEHIVK 74 Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 E+ G K + +VME + G L + + + I E + YLH+ Sbjct: 75 YKGCCED--QGEKSVQLVMEYVPLGSLRDYLPR---HCVGLAQLLLFAQQICEGMAYLHA 129 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAK---ETTSHNSLTTPCYTP-YYVAPEVL 235 + HR + N+L + R ++K+ DFG AK E + + +P ++ APE L Sbjct: 130 QHYIHRALAARNVLLDNDR---LVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECL 186 Query: 236 GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHG-----LAISPGMKTRIRMGQY-----E 285 K+ + D+WS GV +Y LL S H + + G T +R+ + Sbjct: 187 KECKFYYASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVLRLTELLERGER 246 Query: 286 FPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTK 330 P P+ E+ L++N +TE + R T F N I+Q+ + Sbjct: 247 LPRPD--RCPCEIYHLMKNCWETEASFRPT---FQNLVPILQTAQ 286 >5HI2-A nrPDB Length = 283 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 54/221 (24%), Positives = 101/221 (45%), Gaps = 30/221 (13%) Query: 61 DDYKV------TSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWRAS 112 DD+++ Q +G G G V + + A+KML Q + EV + R + Sbjct: 13 DDWEIPDGQITVGQRIGSGSFGTV---YKGKWHGDVAVKMLTPQQLQAFKNEVGV-LRKT 68 Query: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 + +I+ + Y+ + L IV + +G L+ + + F ++ +I + Sbjct: 69 RHVNILLFMG-----YSTKPQLAIVTQWCEGSSLYHHLH-ASETKFEMKKLIDIARQTAR 122 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFA----KETTSHNSLTTPCYTPY 228 + YLH+ +I HRD+K N+ + +K+ DFG A + + SH + Sbjct: 123 GMDYLHAKSIIHRDLKSNNIFL---HEDNTVKIGDFGLATVKSRWSGSHQ-FEQLSGSIL 178 Query: 229 YVAPEVLGPEK---YDKSCDMWSLGVIMYILLCGYPPFYSN 266 ++APEV+ + Y D+++ G+++Y L+ G P YSN Sbjct: 179 WMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLP-YSN 218 >5A46-A nrPDB Length = 386 Score = 55.1 bits (131), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 41/170 (24%), Positives = 77/170 (45%), Gaps = 14/170 (8%) Query: 155 DQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET 214 ++ + ++ + ++YL S HRD+ N+L T + ++K+ DFG A++ Sbjct: 156 EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI 212 Query: 215 --TSHNSLTTPCYTPY-YVAPEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPFYSNHGLA 270 + TT P ++APE L Y D+WS GV+++ I G P+ G+ Sbjct: 213 HHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY---PGVP 269 Query: 271 ISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM 320 + K + + P S + E+ M++R+ P+QR T + + Sbjct: 270 VEELFKLLKEGHRMDKP----SNCTNELYMMMRDCWHAVPSQRPTFKQLV 315 >5GRN-A nrPDB Length = 356 Score = 54.7 bits (130), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 67/290 (23%), Positives = 115/290 (39%), Gaps = 50/290 (17%) Query: 62 DYKVTSQVLGLGINGKVLQ---IFNKRTQ--EKFALKMLQDCPKARRE------VELHWR 110 D V +VLG G GKV++ R+Q K A+KML+ P AR EL Sbjct: 46 DGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLK--PTARSSEKQALMSELKIM 103 Query: 111 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDG-----------------------GELF 147 PH+ IV++ +I C G E+ Sbjct: 104 THLGPHL-NIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVK 162 Query: 148 SRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTD 207 + + D + T + + +++L S N HRD+ N+L + I+K+ D Sbjct: 163 NLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGK---IVKICD 219 Query: 208 FGFAKETTSHNSLTTPCYTPY---YVAPEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPF 263 FG A++ ++ + T ++APE + Y D+WS G++++ I G P+ Sbjct: 220 FGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPY 279 Query: 264 YSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQR 313 G+ + +I+ G Y P+ + EV ++ +EP +R Sbjct: 280 ---PGMMVDSTFYNKIKSG-YRMAKPD--HATSEVYEIMVKCWNSEPEKR 323 >3GQL-A nrPDB Length = 326 Score = 54.7 bits (130), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 41/170 (24%), Positives = 77/170 (45%), Gaps = 14/170 (8%) Query: 155 DQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET 214 ++ + ++ + ++YL S HRD+ N+L T + ++K+ DFG A++ Sbjct: 144 EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI 200 Query: 215 --TSHNSLTTPCYTPY-YVAPEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPFYSNHGLA 270 + TT P ++APE L Y D+WS GV+++ I G P+ G+ Sbjct: 201 HHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY---PGVP 257 Query: 271 ISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM 320 + K + + P S + E+ M++R+ P+QR T + + Sbjct: 258 VEELFKLLKEGHRMDKP----SNCTNELYMMMRDCWHAVPSQRPTFKQLV 303 >4Y12-A nrPDB Length = 375 Score = 54.3 bits (129), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 61/213 (28%), Positives = 91/213 (42%), Gaps = 37/213 (17%) Query: 115 PHIVRIVDVYENL-YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEA 173 P IV+I + E+ G IVME + GG+ R + Q EA + I A Sbjct: 178 PSIVQIFNFVEHTDRHGDPVGYIVMEYV-GGQSLKRSKG---QKLPVAEAIAYLLEILPA 233 Query: 174 IQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPE 233 + YLHSI + + D+KPEN++ T ++ LKL D G S L TP + APE Sbjct: 234 LSYLHSIGLVYNDLKPENIMLTEEQ----LKLIDLGAVSRINSFGYLYG---TPGFQAPE 286 Query: 234 VL--GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW 291 ++ GP + D++++G + L P R G+Y PE Sbjct: 287 IVRTGPT---VATDIYTVGRTLAALTLDLP-----------------TRNGRYVDGLPED 326 Query: 292 SEV---SEEVKMLIRNLLKTEPTQRMTITEFMN 321 V + L+R + +P QR T E M+ Sbjct: 327 DPVLKTYDSYGRLLRRAIDPDPRQRFTTAEEMS 359 >3KRL-A nrPDB Length = 335 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 64/308 (20%), Positives = 126/308 (40%), Gaps = 42/308 (13%) Query: 32 PAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFA 91 P Q P +FP+ +++ G + A V + GLG VL++ A Sbjct: 32 PTQLPYNEKWEFPRNNLQFGKTLGAGAF--GKVVEATAFGLGKEDAVLKV---------A 80 Query: 92 LKMLQDCPKARREVELHWRASQCPHIVR---IVDVYENLYAGRKCLLIVMECLDGGELFS 148 +KML+ A + L H+ + IV++ G L+I C G +L + Sbjct: 81 VKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYG-DLLN 139 Query: 149 RIQDRG--------------DQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLY 194 ++ + ++ + R+ + + + +L S N HRDV N+L Sbjct: 140 FLRRKRPPGLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLL 199 Query: 195 TSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY---YVAPEVLGPEKYDKSCDMWSLGV 251 T+ + K+ DFG A++ + ++ ++APE + Y D+WS G+ Sbjct: 200 TNGH---VAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGI 256 Query: 252 IMY-ILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEP 310 +++ I G P+ G+ ++ ++ G Y+ P ++ + + +++ EP Sbjct: 257 LLWEIFSLGLNPY---PGILVNSKFYKLVKDG-YQMAQPAFA--PKNIYSIMQACWALEP 310 Query: 311 TQRMTITE 318 T R T + Sbjct: 311 THRPTFQQ 318 >2DQ7-X nrPDB Length = 283 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 45/190 (23%), Positives = 83/190 (43%), Gaps = 21/190 (11%) Query: 134 LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL 193 + IV E ++ G L ++D +A ++ + + Y+ +N HRD++ N+L Sbjct: 78 IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANIL 137 Query: 194 YTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV 251 + I K+ DFG A+ E + + + + APE ++ D+WS G+ Sbjct: 138 VGN---GLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 194 Query: 252 IMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQ----YEFPNPEWSEVSEEVKMLIRNLL 306 ++ L+ G P+ PGM R + Q Y P P+ +S + L+ + Sbjct: 195 LLTELVTKGRVPY---------PGMNNREVLEQVERGYRMPCPQDCPIS--LHELMIHCW 243 Query: 307 KTEPTQRMTI 316 K +P +R T Sbjct: 244 KKDPEERPTF 253 >5VC6-A nrPDB Length = 289 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 41/142 (28%), Positives = 67/142 (47%), Gaps = 14/142 (9%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRIVD 122 +G G G V + + +A+K + D A REV H Q H+VR Sbjct: 19 IGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVR--- 75 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQD--RGDQAFTEREASEIMKSIGEAIQYLHSI 180 Y + +A +LI E +GG L I + R F E E +++ +G ++Y+HS+ Sbjct: 76 -YFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSM 134 Query: 181 NIAHRDVKPENLLYT-SKRPNA 201 ++ H D+KP N+ + + PNA Sbjct: 135 SLVHMDIKPSNIFISRTSIPNA 156 >2Y4I-B nrPDB Length = 319 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 66/275 (24%), Positives = 119/275 (43%), Gaps = 52/275 (18%) Query: 76 GKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRASQCPHIVRIVDVYENLYA 129 G+ Q+++ R + A++++ +D KA + + +R ++ ++V L+ Sbjct: 44 GRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVV--------LFM 95 Query: 130 GRKC-----LLIVMECLDGGELFSRIQDRG---DQAFTEREASEIMKSIGEAIQYLHSIN 181 G C L I+ G L+S ++D D T + A EI+K +G YLH+ Sbjct: 96 G-ACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMG----YLHAKG 150 Query: 182 IAHRDVKPENLLYTSKRPNAILKLTDFGF------AKETTSHNSLTTPCYTPYYVAPEV- 234 I H+D+K +N+ Y N + +TDFG + + L ++APE+ Sbjct: 151 ILHKDLKSKNVFY----DNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEII 206 Query: 235 --LGPEK------YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286 L P+ + K D+++LG I Y L PF + AI M T ++ Sbjct: 207 RQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMK------ 260 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMN 321 PN + +E+ ++ E +R T T+ M+ Sbjct: 261 PNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMD 295 >3TT0-A nrPDB Length = 382 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 41/170 (24%), Positives = 77/170 (45%), Gaps = 14/170 (8%) Query: 155 DQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET 214 ++ + ++ + ++YL S HRD+ N+L T + ++K+ DFG A++ Sbjct: 185 EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI 241 Query: 215 --TSHNSLTTPCYTPY-YVAPEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPFYSNHGLA 270 + TT P ++APE L Y D+WS GV+++ I G P+ G+ Sbjct: 242 HHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY---PGVP 298 Query: 271 ISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM 320 + K + + P S + E+ M++R+ P+QR T + + Sbjct: 299 VEELFKLLKEGHRMDKP----SNCTNELYMMMRDCWHAVPSQRPTFKQLV 344 >4R7H-A nrPDB Length = 343 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 72/319 (22%), Positives = 128/319 (40%), Gaps = 50/319 (15%) Query: 32 PAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFA 91 P Q P +FP+ +++ G + A V + GLG VL++ A Sbjct: 36 PTQLPYNEKWEFPRNNLQFGKTLGAGAF--GKVVEATAFGLGKEDAVLKV---------A 84 Query: 92 LKMLQDCPKARREVELHWRASQCPHIVR---IVDVYENLYAGRKCLLIVMECLDGGEL-F 147 +KML+ A + L H+ + IV++ G L+I C G L F Sbjct: 85 VKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNF 144 Query: 148 SRIQ------------------DRGDQAFTE-REASEIMKSIGEAIQYLHSINIAHRDVK 188 R + D+ D E R+ + + + +L S N HRDV Sbjct: 145 LRRKAEAMLGPSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVA 204 Query: 189 PENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY---YVAPEVLGPEKYDKSCD 245 N+L T+ + K+ DFG A++ + ++ ++APE + Y D Sbjct: 205 ARNVLLTNGH---VAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDSVYTVQSD 261 Query: 246 MWSLGVIMY-ILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRN 304 +WS G++++ I G P+ G+ ++ ++ G Y+ P ++ + + +++ Sbjct: 262 VWSYGILLWEIFSLGLNPY---PGILVNSKFYKLVKDG-YQMAQPAFA--PKNIYSIMQA 315 Query: 305 LLKTEPTQRMT---ITEFM 320 EPT R T IT F+ Sbjct: 316 CWALEPTHRPTFQQITSFL 334 >3AOX-A nrPDB Length = 344 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 37/138 (26%), Positives = 62/138 (44%), Gaps = 9/138 (6%) Query: 135 LIVMECLDGGELFSRIQD---RGDQ--AFTEREASEIMKSIGEAIQYLHSINIAHRDVKP 189 I++E + GG+L S +++ R Q + + + + I QYL + HRD+ Sbjct: 126 FILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAA 185 Query: 190 ENLLYTSKRPNAILKLTDFGFAKET--TSHNSLTTPCYTPY-YVAPEVLGPEKYDKSCDM 246 N L T P + K+ DFG A++ S+ P ++ PE + D Sbjct: 186 RNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDT 245 Query: 247 WSLGVIMY-ILLCGYPPF 263 WS GV+++ I GY P+ Sbjct: 246 WSFGVLLWEIFSLGYMPY 263 >4K33-A nrPDB Length = 325 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 42/172 (24%), Positives = 77/172 (44%), Gaps = 18/172 (10%) Query: 155 DQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET 214 ++ T ++ + ++YL S HRD+ N+L T + ++K+ DFG A++ Sbjct: 152 EEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE---DNVMKIADFGLARDV 208 Query: 215 TSHN----SLTTPCYTPY-YVAPEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPFYSNHG 268 HN TT P ++APE L Y D+WS GV+++ I G P+ G Sbjct: 209 --HNLDYYKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPY---PG 263 Query: 269 LAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM 320 + + K + + P + + ++ M++R P+QR T + + Sbjct: 264 IPVEELFKLLKEGHRMDKP----ANCTHDLYMIMRECWHAAPSQRPTFKQLV 311 >5AMN-A nrPDB Length = 299 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 64/271 (23%), Positives = 118/271 (43%), Gaps = 36/271 (13%) Query: 65 VTSQVLGLGINGKVLQI--FNKRTQEKF---ALKMLQD--CPKARREVELHW---RASQC 114 V + LG G GKV++ F+ + + + A+KML++ P R++ + + Sbjct: 26 VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNH 85 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDR--------GDQAFTEREASEI 166 PH++++ LL+++E G L +++ ++A T + Sbjct: 86 PHVIKLYGACSQ----DGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISF 141 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 226 I + +QYL + + HRD+ N+L R +K++DFG +++ +S Sbjct: 142 AWQISQGMQYLAEMKLVHRDLAARNILVAEGRK---MKISDFGLSRDVYEEDSYVKRSQG 198 Query: 227 PY---YVAPEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPFYSNHGLAISPGMKTRIRMG 282 ++A E L Y D+WS GV+++ I+ G P+ + +KT RM Sbjct: 199 RIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRM- 257 Query: 283 QYEFPNPEWSEVSEEVKMLIRNLLKTEPTQR 313 E P+ SEE+ L+ K EP +R Sbjct: 258 --ERPD----NCSEEMYRLMLQCWKQEPDKR 282 >2H8H-A nrPDB Length = 535 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 44/189 (23%), Positives = 77/189 (40%), Gaps = 19/189 (10%) Query: 134 LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL 193 + IV E + G L ++ + + ++ I + Y+ +N HRD++ N+L Sbjct: 336 IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANIL 395 Query: 194 YTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV 251 N + K+ DFG A+ E + + + + APE ++ D+WS G+ Sbjct: 396 VGE---NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 452 Query: 252 IMYILLCGYPPFYSNHGLAISPGMKTRIRMGQ----YEFPNPEWSEVSEEVKMLIRNLLK 307 ++ L + G PGM R + Q Y P P E E + L+ + Sbjct: 453 LLTEL--------TTKGRVPYPGMVNREVLDQVERGYRMPCP--PECPESLHDLMCQCWR 502 Query: 308 TEPTQRMTI 316 EP +R T Sbjct: 503 KEPEERPTF 511 >3QUP-A nrPDB Length = 323 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 68/292 (23%), Positives = 119/292 (40%), Gaps = 36/292 (12%) Query: 67 SQVLGLGINGKVLQIFNKRTQEKF---ALKMLQDCPKARREVELHWRASQC------PHI 117 ++LG G G V + K+ F A+KML+ A ++E R + C PH+ Sbjct: 28 GRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHV 87 Query: 118 VRIVDVYENLYA-GRKCL-LIVMECLDGGEL--FSRIQDRGDQAFTE--REASEIMKSIG 171 ++V V A GR + ++++ + G+L F G+ F + M I Sbjct: 88 AKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFMVDIA 147 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY--- 228 ++YL S N HRD+ N + + + + DFG +++ S + C + Sbjct: 148 CGMEYLSSRNFIHRDLAARNCMLAE---DMTVCVADFGLSRKIYSGDYYRQGCASKLPVK 204 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 ++A E L Y D+W+ GV M+ I+ G P+ I + +G Sbjct: 205 WLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYL-----IGGNRLK 259 Query: 288 NPEWSEVSEEVKMLIRNLLKTEPTQ-------RMTITEFMNHPWIMQSTKVP 332 P E EEV L+ +P Q RM + + H ++ +++ P Sbjct: 260 QP--PECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGHLSVLSTSQDP 309 >5KMM-A nrPDB Length = 329 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 67/301 (22%), Positives = 121/301 (40%), Gaps = 40/301 (13%) Query: 40 PQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP 99 PQ F V IK+ I+ +++ G + + ++ + A+K L++ Sbjct: 21 PQYFSDACVH---HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEAS 77 Query: 100 KA-----RREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRG 154 ++ +RE EL Q HIVR V GR LL+V E + G+L ++ G Sbjct: 78 ESARQDFQREAEL-LTMLQHQHIVRFFGVCTE---GRP-LLMVFEYMRHGDLNRFLRSHG 132 Query: 155 DQA-------------FTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNA 201 A + + + + YL ++ HRD+ N L Sbjct: 133 PDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ---GL 189 Query: 202 ILKLTDFGFAKETTSHNSLTTPCYTPY---YVAPEVLGPEKYDKSCDMWSLGVIMY-ILL 257 ++K+ DFG +++ S + T ++ PE + K+ D+WS GV+++ I Sbjct: 190 VVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFT 249 Query: 258 CGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTIT 317 G P+Y L+ + + + + E P EV ++R + EP QR +I Sbjct: 250 YGKQPWYQ---LSNTEAIDCITQGRELERPRA----CPPEVYAIMRGCWQREPQQRHSIK 302 Query: 318 E 318 + Sbjct: 303 D 303 >6F3F-A nrPDB Length = 455 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 44/189 (23%), Positives = 78/189 (41%), Gaps = 19/189 (10%) Query: 134 LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL 193 + IV E ++ G L ++ + + ++ I + Y+ +N HRD++ N+L Sbjct: 256 IYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANIL 315 Query: 194 YTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV 251 N + K+ DFG A+ E + + + + APE ++ D+WS G+ Sbjct: 316 VGE---NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 372 Query: 252 IMYILLCGYPPFYSNHGLAISPGMKTRIRMGQ----YEFPNPEWSEVSEEVKMLIRNLLK 307 ++ L + G PGM R + Q Y P P E E + L+ + Sbjct: 373 LLTEL--------TTKGRVPYPGMVNREVLDQVERGYRMPCP--PECPESLHDLMCQCWR 422 Query: 308 TEPTQRMTI 316 EP +R T Sbjct: 423 KEPEERPTF 431 >5HIE-A nrPDB Length = 302 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 54/221 (24%), Positives = 101/221 (45%), Gaps = 30/221 (13%) Query: 61 DDYKV------TSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWRAS 112 DD+++ Q +G G G V + + A+KML Q + EV + R + Sbjct: 29 DDWEIPDGQITVGQRIGSGSFGTV---YKGKWHGDVAVKMLTPQQLQAFKNEVGV-LRKT 84 Query: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 + +I+ + Y+ + L IV + +G L+ + + F + +I + + Sbjct: 85 RHVNILLFMG-----YSTKPQLAIVTQWCEGSSLYHHLHII-ETKFEMIKLIDIARQTAQ 138 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFA----KETTSHNSLTTPCYTPY 228 + YLH+ +I HRD+K N+ + +K+ DFG A + + SH + Sbjct: 139 GMDYLHAKSIIHRDLKSNNIFL---HEDLTVKIGDFGLATVKSRWSGSHQ-FEQLSGSIL 194 Query: 229 YVAPEVLGPEK---YDKSCDMWSLGVIMYILLCGYPPFYSN 266 ++APEV+ + Y D+++ G+++Y L+ G P YSN Sbjct: 195 WMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLP-YSN 234 >4XCU-A nrPDB Length = 300 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 37/139 (26%), Positives = 62/139 (44%), Gaps = 12/139 (8%) Query: 134 LLIVMECLDGGELFSRIQDRGDQAFTEREAS-----EIMKSIGEAIQYLHSINIAHRDVK 188 L +++EC G L ++ R +E S + +QYL S HRD+ Sbjct: 98 LYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLA 157 Query: 189 PENLLYTSKRPNAILKLTDFGFAKET--TSHNSLTTPCYTPY-YVAPEVLGPEKYDKSCD 245 N+L T + ++K+ DFG A+ + T+ P ++APE L Y D Sbjct: 158 ARNVLVTE---DNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSD 214 Query: 246 MWSLGVIMY-ILLCGYPPF 263 +WS G++++ I G P+ Sbjct: 215 VWSFGILLWEIFTLGGSPY 233 >2JD5-A nrPDB Length = 373 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 67/301 (22%), Positives = 115/301 (38%), Gaps = 63/301 (20%) Query: 92 LKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQ 151 +K+LQ A E + HI++++D + + +++V E L G L + I+ Sbjct: 66 IKLLQRVNDADNTKE---DSMGANHILKLLDHFNHKGPNGVHVVMVFEVL-GENLLALIK 121 Query: 152 DRGDQAFTEREASEIMKSIGEAIQYLHS-INIAHRDVKPENLLY--TSKRPNAI-LKLTD 207 + +I K + + Y+H I H D+KPEN+L N I +K+ D Sbjct: 122 KYEHRGIPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIAD 181 Query: 208 FGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH 267 G A H T T Y +PEVL + D+WS +++ L+ G F + Sbjct: 182 LGNACWYDEH--YTNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDE 239 Query: 268 GLA----------------------ISPGMKTR----------------------IRMGQ 283 G + + G TR + + Sbjct: 240 GHSYTKDDDHIAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEK 299 Query: 284 YEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI-----MQSTKVPQTPLHT 338 Y+F E E+S+ + +L+ +P +R +NHPW+ M+ +VP L+ Sbjct: 300 YKFSKDEAKEISD----FLSPMLQLDPRKRADAGGLVNHPWLKDTLGMEEIRVPDRELYG 355 Query: 339 S 339 S Sbjct: 356 S 356 >3LLT-A nrPDB Length = 360 Score = 51.6 bits (122), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 56/236 (23%), Positives = 100/236 (42%), Gaps = 31/236 (13%) Query: 55 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK----ARREVELHWR 110 KK ++++ + + +G G G+VL + ++ +A+K++++ K A+ E ++ + Sbjct: 28 KKGMLLNNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKK 87 Query: 111 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 + Y + + ++ E L G L+ I F + I Sbjct: 88 IQNDDINNNNIVKYHGKFMYYDHMCLIFEPL-GPSLYEIITRNNYNGFHIEDIKLYCIEI 146 Query: 171 GEAIQYLHSINIAHRDVKPENLL----YTSKRPNAI------------------LKLTDF 208 +A+ YL +++ H D+KPEN+L Y K + +KL DF Sbjct: 147 LKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDF 206 Query: 209 GFAK-ETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPF 263 G A ++ H S+ T Y APEV+ +D S DMWS G ++ L G F Sbjct: 207 GCATFKSDYHGSIIN---TRQYRAPEVILNLGWDVSSDMWSFGCVLAELYTGSLLF 259 >5SYS-A nrPDB Length = 286 Score = 51.6 bits (122), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 43/189 (22%), Positives = 77/189 (40%), Gaps = 19/189 (10%) Query: 134 LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL 193 + IV E + G L ++ + + ++ I + Y+ +N HRD++ N+L Sbjct: 87 IYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANIL 146 Query: 194 YTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV 251 N + K+ DFG A+ E + + + + APE ++ D+WS G+ Sbjct: 147 VGE---NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 203 Query: 252 IMYILLCGYPPFYSNHGLAISPGMKTRIRMGQ----YEFPNPEWSEVSEEVKMLIRNLLK 307 ++ L + G PGM R + Q Y P P E E + L+ + Sbjct: 204 LLTEL--------TTKGRVPYPGMVNREVLDQVERGYRMPCP--PECPESLHDLMCQCWR 253 Query: 308 TEPTQRMTI 316 +P +R T Sbjct: 254 KDPEERPTF 262 >6NPU-A nrPDB Length = 298 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 43/191 (22%), Positives = 80/191 (41%), Gaps = 19/191 (9%) Query: 134 LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL 193 I+ E + G L +++ Q + I A++YL N HRD+ N L Sbjct: 97 FYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCL 156 Query: 194 YTSKRPNAILKLTDFGFAKETT--SHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV 251 N ++K+ DFG ++ T ++ + + + APE L K+ D+W+ GV Sbjct: 157 VGE---NHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGV 213 Query: 252 IMYILLCGYPPFYSNHGLAISPGMKT----RIRMGQYEFPNPEWSEVSEEVKMLIRNLLK 307 +++ + + +G++ PG+ + Y PE E+V L+R + Sbjct: 214 LLWEI--------ATYGMSPYPGIDLSQVYELLEKDYRMERPE--GCPEKVYELMRACWQ 263 Query: 308 TEPTQRMTITE 318 P+ R + E Sbjct: 264 WNPSDRPSFAE 274 >4XEY-B nrPDB Length = 408 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 34/134 (25%), Positives = 59/134 (44%), Gaps = 8/134 (5%) Query: 134 LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL 193 I+ E + G L +++ Q + I A++YL N HRD+ N L Sbjct: 196 FYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCL 255 Query: 194 YTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY---YVAPEVLGPEKYDKSCDMWSLG 250 N ++K+ DFG ++ T ++ T + + APE L K+ D+W+ G Sbjct: 256 VGE---NHLVKVADFGLSRLMTG-DTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFG 311 Query: 251 VIMY-ILLCGYPPF 263 V+++ I G P+ Sbjct: 312 VLLWEIATYGMSPY 325 >4NFN-A nrPDB Length = 309 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 58/220 (26%), Positives = 94/220 (42%), Gaps = 23/220 (10%) Query: 58 AIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM-LQDCPKA--RREVELHWRASQC 114 + D +KV ++ G G G++ + + T+E ALK+ PK + EV + + Sbjct: 18 VVKDRWKVLKKIGGGGF-GEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGK 76 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGEL--FSRIQDRGDQAFTEREASEIMKSIGE 172 H+ R + N K +VM+ L G L R Q RG FT + K I E Sbjct: 77 DHVCRFIGCGRN----EKFNYVVMQ-LQGRNLADLRRSQPRG--TFTLSTTLRLGKQILE 129 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILK--LTDFGFAKETTSHNSLTTP------- 223 +I+ +HS+ HRD+KP N + P+ K + DFG A++ T+ P Sbjct: 130 SIEAIHSVGFLHRDIKPSNFA-MGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGF 188 Query: 224 CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPF 263 T Y + + + D+WSL ++ G P+ Sbjct: 189 RGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPW 228 >4BTK-A nrPDB Length = 337 Score = 51.2 bits (121), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 58/220 (26%), Positives = 94/220 (42%), Gaps = 23/220 (10%) Query: 58 AIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM-LQDCPKA--RREVELHWRASQC 114 + D +KV ++ G G G++ + + T+E ALK+ PK + EV + + Sbjct: 53 VVKDRWKVLKKIGGGGF-GEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGK 111 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGEL--FSRIQDRGDQAFTEREASEIMKSIGE 172 H+ R + N K +VM+ L G L R Q RG FT + K I E Sbjct: 112 DHVCRFIGCGRN----EKFNYVVMQ-LQGRNLADLRRSQPRG--TFTLSTTLRLGKQILE 164 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILK--LTDFGFAKETTSHNSLTTP------- 223 +I+ +HS+ HRD+KP N + P+ K + DFG A++ T+ P Sbjct: 165 SIEAIHSVGFLHRDIKPSNFA-MGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGF 223 Query: 224 CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPF 263 T Y + + + D+WSL ++ G P+ Sbjct: 224 RGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPW 263 >5FM2-A nrPDB Length = 355 Score = 51.2 bits (121), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 43/163 (26%), Positives = 73/163 (44%), Gaps = 14/163 (8%) Query: 155 DQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET 214 ++A T + I + +QYL + + HRD+ N+L R +K++DFG +++ Sbjct: 185 ERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRK---MKISDFGLSRDV 241 Query: 215 TSHNSLTTPCYTPY---YVAPEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPFYSNHGLA 270 +S ++A E L Y D+WS GV+++ I+ G P+ Sbjct: 242 YEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPER 301 Query: 271 ISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQR 313 + +KT RM E P+ SEE+ L+ K EP +R Sbjct: 302 LFNLLKTGHRM---ERPD----NCSEEMYRLMLQCWKQEPDKR 337 >3V5Q-A nrPDB Length = 297 Score = 50.8 bits (120), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 62/228 (27%), Positives = 102/228 (44%), Gaps = 36/228 (15%) Query: 65 VTSQVLGLGINGKVL--QIFNKR-TQEKF--ALKMLQDCPKA-----RREVELHWRASQC 114 V + LG G GKV + +N T++K A+K L+D A +RE EL Q Sbjct: 18 VLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAEL-LTNLQH 76 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRG-----------DQAFTEREA 163 HIV+ V + L++V E + G+L ++ G QA E Sbjct: 77 EHIVKFYGVCGD----GDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGL 132 Query: 164 SEIM---KSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL 220 S+++ I + YL S + HRD+ N L + N ++K+ DFG +++ S + Sbjct: 133 SQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGA---NLLVKIGDFGMSRDVYSTDYY 189 Query: 221 TTPCYTPY---YVAPEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPFY 264 +T ++ PE + K+ D+WS GVI++ I G P++ Sbjct: 190 RVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWF 237 >5VDK-A nrPDB Length = 297 Score = 50.8 bits (120), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 63/275 (22%), Positives = 113/275 (41%), Gaps = 49/275 (17%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKM-------LQDCPKARREVELHWRASQCPHIVRIVD 122 +G+G G V + + +A+K L + A EV H PH+VR Sbjct: 23 IGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHHPHVVR--- 79 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQD--RGDQAFTEREASEIMKSIGEAIQYLHSI 180 Y + +A ++I E +GG L + I + + F E + +I+ I + Y+H+ Sbjct: 80 -YYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYIHNS 138 Query: 181 NIAHRDVKPENLLYTSK--------------------RPNAILKLTDFGFAKETTSHNSL 220 ++ H D+KP N+ K N + K+ D G A TS N Sbjct: 139 SMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHA---TSINKP 195 Query: 221 TTPCYTPYYVAPEVLGPE-KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRI 279 ++A E+L + ++ D+++LG+ + + L + I Sbjct: 196 KVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGA-------ESLPTNGAAWHHI 248 Query: 280 RMGQYEFPN-PEWSEVSEEVKMLIRNLLKTEPTQR 313 R G FP+ P+ E+SE L++N+++ + QR Sbjct: 249 RKGN--FPDVPQ--ELSESFSSLLKNMIQPDAEQR 279 >3VHK-A nrPDB Length = 368 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 38/157 (24%), Positives = 72/157 (45%), Gaps = 13/157 (8%) Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY- 228 + + +++L S HRD+ N+L + K ++K+ DFG A++ Sbjct: 209 VAKGMEFLASRKCIHRDLAARNILLSEKN---VVKICDFGLARDIYKDPDYVRKGDARLP 265 Query: 229 --YVAPEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPFYSNHGLAISPGMKTRIRMGQYE 285 ++APE + Y D+WS GV+++ I G P+ G+ I R++ G Sbjct: 266 LKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPY---PGVKIDEEFCRRLKEGT-R 321 Query: 286 FPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNH 322 P+++ + E+ + + EP+QR T +E + H Sbjct: 322 MRAPDYT--TPEMYQTMLDCWHGEPSQRPTFSELVEH 356 >3ZBF-A nrPDB Length = 322 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 62/264 (23%), Positives = 119/264 (45%), Gaps = 48/264 (18%) Query: 43 FPQFHVKSGLQIKKNAIIDDYKVTS-QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKA 101 FP+ + L + A + Y+ T+ +LG+G +G++ K A+K L+ Sbjct: 30 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVG-SGEI----------KVAVKTLKKGSTD 78 Query: 102 RREVELHWRAS-----QCPHIVRIVDVYENLYAGRKCLL-----IVMECLDGGELFSRIQ 151 + ++E A P+I++ + V CLL I++E ++GG+L + ++ Sbjct: 79 QEKIEFLKEAHLMSKFNHPNILKQLGV---------CLLNEPQYIILELMEGGDLLTYLR 129 Query: 152 DRGDQAF-----TEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL-----YTSKRPNA 201 F T + ++ I + YL ++ HRD+ N L YTS R Sbjct: 130 KARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPR--- 186 Query: 202 ILKLTDFGFAKETTSHNSL---TTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMY-ILL 257 I+K+ DFG A++ ++ ++APE L + D+WS G++++ IL Sbjct: 187 IVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILT 246 Query: 258 CGYPPFYSNHGLAISPGMKTRIRM 281 G+ P+ ++ L + ++T R+ Sbjct: 247 LGHQPYPAHSNLDVLNYVQTGGRL 270 >3QGY-A nrPDB Length = 286 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 33/135 (24%), Positives = 58/135 (42%), Gaps = 14/135 (10%) Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS--HNSLTTPCYTP 227 + E + YL + HRD+ N L N ++K++DFG + + S T + Sbjct: 132 VCEGMAYLEEACVIHRDLAARNCLVG---ENQVIKVSDFGMTRFVLDDQYTSSTGTKFPV 188 Query: 228 YYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQ--- 283 + +PEV +Y D+WS GV+M+ + G P+ + + + T R+ + Sbjct: 189 KWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRL 248 Query: 284 -----YEFPNPEWSE 293 Y+ N W E Sbjct: 249 ASTHVYQIMNHCWKE 263 >2HK5-A nrPDB Length = 270 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 39/154 (25%), Positives = 66/154 (42%), Gaps = 21/154 (13%) Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCYTP 227 I E + ++ N HRD++ N+L ++ + + K+ DFG A+ E + + + Sbjct: 120 IAEGMAFIEQRNYIHRDLRAANILVSA---SLVCKIADFGLARVIEDNEYTAREGAKFPI 176 Query: 228 YYVAPEVLGPEKYDKSCDMWSLGV-IMYILLCGYPPFYSNHGLAISPGMKT----RIRMG 282 + APE + + D+WS G+ +M I+ G P+ PGM R Sbjct: 177 KWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPY---------PGMSNPEVIRALER 227 Query: 283 QYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTI 316 Y P PE EE+ ++ K P +R T Sbjct: 228 GYRMPRPE--NCPEELYNIMMRCWKNRPEERPTF 259 >3CJF-A nrPDB Length = 309 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 60/275 (21%), Positives = 116/275 (42%), Gaps = 31/275 (11%) Query: 70 LGLGINGKVLQ-----IFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVY 124 LG G G+V++ I T A+KML++ L HI ++V Sbjct: 35 LGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVV 94 Query: 125 ENLYAGRKC---LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS----------IG 171 L A K L++++E G L + ++ + ++ ++ + + + Sbjct: 95 NLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEHLICYSFQVA 154 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY--- 228 + +++L S HRD+ N+L + K ++K+ DFG A++ Sbjct: 155 KGMEFLASRKCIHRDLAARNILLSEKN---VVKICDFGLARDIYKDPDYVRKGDARLPLK 211 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 ++APE + Y D+WS GV+++ I G P+ G+ I R++ G Sbjct: 212 WMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPY---PGVKIDEEFCRRLKEGT-RMR 267 Query: 288 NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNH 322 P+++ + E+ + + EP+QR T +E + H Sbjct: 268 APDYT--TPEMYQTMLDCWHGEPSQRPTFSELVEH 300 >3I81-A nrPDB Length = 315 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 48/213 (22%), Positives = 91/213 (42%), Gaps = 29/213 (13%) Query: 64 KVT-SQVLGLGINGKVLQ-----IFNKRTQEKFALKMLQDCPKARREVELHWRAS----- 112 K+T S+ LG G G V + + + + A+K + + R +E AS Sbjct: 19 KITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEF 78 Query: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQD-----RGDQAFTEREASEIM 167 C H+VR++ V + L++ME + G+L S ++ + S+++ Sbjct: 79 NCHHVVRLLGVVSQ----GQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMI 134 Query: 168 KSIGE---AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK---ETTSHNSLT 221 + GE + YL++ HRD+ N + + +K+ DFG + ET + Sbjct: 135 QMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDIYETDYYRKGG 191 Query: 222 TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMY 254 +++PE L + D+WS GV+++ Sbjct: 192 KGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLW 224 >3HNG-A nrPDB Length = 360 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 37/155 (23%), Positives = 72/155 (46%), Gaps = 13/155 (8%) Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY- 228 + +++L S HRD+ N+L + N ++K+ DFG A++ + T Sbjct: 208 VARGMEFLSSRKCIHRDLAARNILLSE---NNVVKICDFGLARDIYKNPDYVRKGDTRLP 264 Query: 229 --YVAPEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPFYSNHGLAISPGMKTRIRMGQYE 285 ++APE + + Y D+WS GV+++ I G P+ G+ + +R+R G Sbjct: 265 LKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPY---PGVQMDEDFCSRLREGM-R 320 Query: 286 FPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM 320 PE+S + E+ ++ + +P +R E + Sbjct: 321 MRAPEYS--TPEIYQIMLDCWHRDPKERPRFAELV 353 >4NT4-A nrPDB Length = 312 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 37/120 (30%), Positives = 57/120 (47%), Gaps = 17/120 (14%) Query: 156 QAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLY--TSKRPNAILKLTDFGFAKE 213 + F+ + I K + I+Y+HS ++ +RDVKPEN L TS + I+ + DFG AKE Sbjct: 109 RKFSLKTVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKE 168 Query: 214 TTSHNSLTTPCYTPYYVAPEVLGPEKY-----------DKSCDMWSLG-VIMYILLCGYP 261 + L T + PY + G +Y + D+ +LG + MY L P Sbjct: 169 ---YIDLDTNRHIPYREHKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLP 225 >2FO0-A nrPDB Length = 495 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 33/134 (24%), Positives = 59/134 (44%), Gaps = 8/134 (5%) Query: 134 LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL 193 I+ E + G L +++ Q + I A++YL N HR++ N L Sbjct: 288 FYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCL 347 Query: 194 YTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY---YVAPEVLGPEKYDKSCDMWSLG 250 N ++K+ DFG ++ T ++ T + + APE L K+ D+W+ G Sbjct: 348 VGE---NHLVKVADFGLSRLMTG-DTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFG 403 Query: 251 VIMY-ILLCGYPPF 263 V+++ I G P+ Sbjct: 404 VLLWEIATYGMSPY 417 >6J5U-C nrPDB Length = 426 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 38/130 (29%), Positives = 62/130 (47%), Gaps = 8/130 (6%) Query: 135 LIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI--NIAHRDVKPENL 192 L+V E + G L + + RG Q T ++ + + +LH + +RD K N+ Sbjct: 166 LLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGAAKGLTFLHEAKSQVIYRDFKAANI 225 Query: 193 LYTSKRPNAILKLTDFGFAKE--TTSHNSLTTPCY-TPYYVAPEVLGPEKYDKSCDMWSL 249 L + NA KL+DFG AK T + ++T T Y APE + + D++S Sbjct: 226 LLDADF-NA--KLSDFGLAKAGPTGDNTHVSTKVIGTHGYAAPEYVATGRLTAKSDVYSF 282 Query: 250 GVIMYILLCG 259 GV++ L+ G Sbjct: 283 GVVLLELISG 292 >2XYN-A nrPDB Length = 292 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 33/133 (24%), Positives = 59/133 (44%), Gaps = 6/133 (4%) Query: 134 LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL 193 IV E + G L +++ + T + I A++YL N HRD+ N L Sbjct: 103 FYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCL 162 Query: 194 YTSKRPNAILKLTDFGFAKETT--SHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV 251 N ++K+ DFG ++ T ++ + + + APE L + D+W+ GV Sbjct: 163 VGE---NHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGV 219 Query: 252 IMY-ILLCGYPPF 263 +++ I G P+ Sbjct: 220 LLWEIATYGMSPY 232 >4TN6-A nrPDB Length = 318 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 32/100 (32%), Positives = 47/100 (47%), Gaps = 15/100 (15%) Query: 174 IQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPE 233 I+Y+HS N HRDVKP+N L + ++ + DFG AK+ + T + PY Sbjct: 116 IEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKK---YRDARTHQHIPYRENKN 172 Query: 234 VLGPEKY-----------DKSCDMWSLG-VIMYILLCGYP 261 + G +Y + D+ SLG V+MY L P Sbjct: 173 LTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLP 212 >5LPZ-A nrPDB Length = 332 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 35/102 (34%), Positives = 54/102 (52%), Gaps = 11/102 (10%) Query: 169 SIGEA--IQYLH---SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT---SHNSL 220 +IG A + +LH S +I HRD+K N+L N +++DFG A+ + +H S+ Sbjct: 123 AIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDE---NLEARVSDFGMARLMSAMDTHLSV 179 Query: 221 TTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPP 262 +T TP YV PE + D++S GV++ LL G P Sbjct: 180 STLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKRP 221 >5LPV-A nrPDB Length = 296 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 41/136 (30%), Positives = 65/136 (47%), Gaps = 11/136 (8%) Query: 135 LIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEA--IQYLH---SINIAHRDVKP 189 L+V E + G L + D ++ +IG A + +LH S +I HRD+K Sbjct: 89 LLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKS 148 Query: 190 ENLLYTSKRPNAILKLTDFGFAKETT---SHNSLTTPCYTPYYVAPEVLGPEKYDKSCDM 246 N+L N +++DFG A+ + +H S++T TP YV PE + D+ Sbjct: 149 SNVLLDE---NLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTKGDV 205 Query: 247 WSLGVIMYILLCGYPP 262 +S GV++ LL G P Sbjct: 206 YSYGVVLLELLTGKRP 221 >2PL0-A nrPDB Length = 289 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 42/190 (22%), Positives = 76/190 (40%), Gaps = 21/190 (11%) Query: 134 LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL 193 + I+ E ++ G L ++ T + ++ I E + ++ N HRD++ N+L Sbjct: 92 IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANIL 151 Query: 194 YTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV 251 + K+ DFG A+ E + + + + APE + + D+WS G+ Sbjct: 152 VSDTLS---CKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGI 208 Query: 252 IMYILLCGYPPFYSNHGLAISPGMKT-----RIRMGQYEFPNPEWSEVSEEVKMLIRNLL 306 ++ ++ HG PGM + G Y P+ EE+ L+R Sbjct: 209 LLTEIV--------THGRIPYPGMTNPEVIQNLERG-YRMVRPD--NCPEELYQLMRLCW 257 Query: 307 KTEPTQRMTI 316 K P R T Sbjct: 258 KERPEDRPTF 267 >3SXS-A nrPDB Length = 268 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 49/219 (22%), Positives = 96/219 (43%), Gaps = 19/219 (8%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR----REVELHWRASQCPHIVRIVDVYE 125 LG G G V+++ + Q A+KM+++ + +E + + S P +V+ V Sbjct: 16 LGSGQFG-VVKLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSH-PKLVKFYGVCS 73 Query: 126 NLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHR 185 Y + IV E + G L + ++ G + + E+ + E + +L S HR Sbjct: 74 KEYP----IYIVTEYISNGCLLNYLRSHG-KGLEPSQLLEMCYDVCEGMAFLESHQFIHR 128 Query: 186 DVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPC--YTPYYVAPEVLGPEKYDKS 243 D+ N L + +K++DFG + +++ + + APEV KY Sbjct: 129 DLAARNCLVDR---DLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSK 185 Query: 244 CDMWSLGVIMY-ILLCGYPPF--YSNHGLAISPGMKTRI 279 D+W+ G++M+ + G P+ Y+N + + R+ Sbjct: 186 SDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRL 224 >5U6C-A nrPDB Length = 315 Score = 47.8 bits (112), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 50/218 (22%), Positives = 100/218 (45%), Gaps = 23/218 (10%) Query: 56 KNAIID-DYKVTSQVLGLGINGKVLQIFNKR---TQEKFALKMLQDCPKARREVELHWRA 111 ++ +ID + + ++LG G G V++ K+ T K A+K ++ ++RE+E Sbjct: 29 EDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSE 88 Query: 112 SQC------PHIVRIVDV-YENLYAGRKCLLIVMECLDGGEL-----FSRIQDRGDQAFT 159 + C P+++R++ V E G ++++ + G+L +SR++ G + Sbjct: 89 AACMKDFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLE-TGPKHIP 147 Query: 160 EREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS 219 + + M I ++YL + N HRD+ N + R + + + DFG +K+ S + Sbjct: 148 LQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCML---RDDMTVCVADFGLSKKIYSGDY 204 Query: 220 LTTPCYTPY---YVAPEVLGPEKYDKSCDMWSLGVIMY 254 ++A E L Y D+W+ GV M+ Sbjct: 205 YRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMW 242 >5UIU-A nrPDB Length = 323 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 32/101 (31%), Positives = 51/101 (50%), Gaps = 7/101 (6%) Query: 165 EIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLTT 222 +I + I +LH + HRD+K N+L K++DFG A+ E + +T+ Sbjct: 153 KIAQGAANGINFLHENHHIHRDIKSANILLDEAFT---AKISDFGLARASEKFAQTVMTS 209 Query: 223 PCY-TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPP 262 T Y+APE L E KS D++S GV++ ++ G P Sbjct: 210 RIVGTTAYMAPEALRGEITPKS-DIYSFGVVLLEIITGLPA 249 >5FQD-C nrPDB Length = 341 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 32/94 (34%), Positives = 44/94 (46%), Gaps = 15/94 (15%) Query: 174 IQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPE 233 I+Y+H+ N HRD+KP+N L R L L DFG AK+ + T + PY Sbjct: 128 IEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNR---TRQHIPYREDKN 184 Query: 234 VLGPEKY-----------DKSCDMWSLG-VIMYI 255 + G +Y + DM SLG V+MY Sbjct: 185 LTGTARYASINAHLGIEQSRRDDMESLGYVLMYF 218 >3A4O-X nrPDB Length = 286 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 39/176 (22%), Positives = 74/176 (42%), Gaps = 16/176 (9%) Query: 134 LLIVMECLDGGELFSRIQ-DRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENL 192 + I+ E + G L ++ D G + + + I E + Y+ N HRD++ N+ Sbjct: 83 IYIITEYMAKGSLLDFLKSDEGGKVLLPK-LIDFSAQIAEGMAYIERKNYIHRDLRAANV 141 Query: 193 LYTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLG 250 L + + + K+ DFG A+ E + + + + APE + + D+WS G Sbjct: 142 LVSE---SLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFG 198 Query: 251 VIMY-ILLCGYPPFYSNHGLAISPGMKTRIRMGQ--------YEFPNPEWSEVSEE 297 +++Y I+ G P+ + + RM + Y+ W E +EE Sbjct: 199 ILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEE 254 >2CMW-A nrPDB Length = 310 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 43/141 (30%), Positives = 65/141 (46%), Gaps = 21/141 (14%) Query: 136 IVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT 195 +V+E L G + D D+ FT + I + ++Y+HS N+ +RDVKPEN L Sbjct: 74 MVLELL--GPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIG 131 Query: 196 --SKRPNAILKLTDFGFAKETTS-----------HNSLTTPCYTPYYVAPEV-LGPEKYD 241 + ++ + DFG AKE H SLT T Y++ LG E+ Sbjct: 132 RQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTG---TARYMSINTHLGKEQ-S 187 Query: 242 KSCDMWSLG-VIMYILLCGYP 261 + D+ +LG + MY L P Sbjct: 188 RRDDLEALGHMFMYFLRGSLP 208 >4XHL-A nrPDB Length = 394 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 28/96 (29%), Positives = 44/96 (45%), Gaps = 15/96 (15%) Query: 174 IQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPE 233 IQY+H + HRD+KP+N L R + + + DFG +K+ N T + PY Sbjct: 116 IQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFN---THRHIPYRENKS 172 Query: 234 VLGPEKY-----------DKSCDMWSLGVIMYILLC 258 + G +Y + D+ SLG ++ I C Sbjct: 173 LTGTARYASVNTHLGIEQSRRDDLESLGYVL-IYFC 207 >3G0E-A nrPDB Length = 336 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 53/221 (23%), Positives = 91/221 (41%), Gaps = 37/221 (16%) Query: 67 SQVLGLGINGKVLQ-----IFNKRTQEKFALKMLQDCPKAR---REV---ELHWRASQCP 115 + LG G GKV++ + A+KML+ P A RE EL + Sbjct: 51 GKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK--PSAHLTEREALMSELKVLSYLGN 108 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS------ 169 H+ IV++ G L+I C G +L + ++ + D + + IM+ Sbjct: 109 HM-NIVNLLGACTIGGPTLVITEYCCYG-DLLNFLRRKRDSFICSKTSPAIMEDDELALD 166 Query: 170 ----------IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS 219 + + + +L S N HRD+ N+L T R I K+ DFG A++ + ++ Sbjct: 167 LEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGR---ITKICDFGLARDIKNDSN 223 Query: 220 LTTPCYTPY---YVAPEVLGPEKYDKSCDMWSLGVIMYILL 257 ++APE + Y D+WS G+ ++ L Sbjct: 224 YVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELF 264 >4HZS-A nrPDB Length = 341 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 33/133 (24%), Positives = 56/133 (42%), Gaps = 9/133 (6%) Query: 144 GELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAIL 203 G L R++ + F S + E + YL S HRD+ NLL ++ ++ Sbjct: 99 GSLLDRLR-KHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATR---DLV 154 Query: 204 KLTDFGFAK---ETTSHNSLTTPCYTPY-YVAPEVLGPEKYDKSCDMWSLGVIMYILLC- 258 K+ DFG + + H + P+ + APE L + + D W GV ++ + Sbjct: 155 KIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTY 214 Query: 259 GYPPFYSNHGLAI 271 G P+ +G I Sbjct: 215 GQEPWIGLNGSQI 227 >3SV0-A nrPDB Length = 483 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 38/151 (25%), Positives = 66/151 (43%), Gaps = 31/151 (20%) Query: 174 IQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPE 233 ++++HS + HRD+KP+N L R + + DFG AK+ + +T + PY Sbjct: 116 VEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKK---YRDTSTHQHIPYRENKN 172 Query: 234 VLGPEKY-----------DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMG 282 + G +Y + D+ SLG ++ L G P+ G+K + Sbjct: 173 LTGTARYASVNTHLGIEQSRRDDLESLGYVLMYFLRGSLPW---------QGLKAGTKKQ 223 Query: 283 QYEFPNPEWSEVSE-EVKMLIRNLLKTEPTQ 312 +YE ++SE +V I L + PT+ Sbjct: 224 KYE-------KISEKKVATSIEALCRGYPTE 247 >1U54-B nrPDB Length = 291 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 33/133 (24%), Positives = 56/133 (42%), Gaps = 9/133 (6%) Query: 144 GELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAIL 203 G L R++ + F S + E + YL S HRD+ NLL ++ ++ Sbjct: 105 GSLLDRLR-KHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATR---DLV 160 Query: 204 KLTDFGFAK---ETTSHNSLTTPCYTPY-YVAPEVLGPEKYDKSCDMWSLGVIMYILLC- 258 K+ DFG + + H + P+ + APE L + + D W GV ++ + Sbjct: 161 KIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTY 220 Query: 259 GYPPFYSNHGLAI 271 G P+ +G I Sbjct: 221 GQEPWIGLNGSQI 233 >2C47-A nrPDB Length = 313 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 62/218 (28%), Positives = 97/218 (44%), Gaps = 29/218 (13%) Query: 62 DYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIV 121 +++V ++ G G G++ N T E A+K+ P R +LH + Sbjct: 5 NFRVGKKI-GCGNFGELRLGKNLYTNEYVAIKL---EPIKSRAPQLHLEYRFYKQLSATE 60 Query: 122 DVYENLYAG--RKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 V + Y G K +V+E L G + D D+ FT + I + ++Y+H+ Sbjct: 61 GVPQVYYFGPCGKYNAMVLELL--GPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHT 118 Query: 180 INIAHRDVKPENLLY---TSKRPNAILKLTDFGFAKETTS-----------HNSLTTPCY 225 ++ +RDVKPEN L +KR +AI + DFG AKE H SLT Sbjct: 119 KSLIYRDVKPENFLVGRPGTKRQHAI-HIIDFGLAKEYIDPETKKHIPYREHKSLTG--- 174 Query: 226 TPYYVAPEV-LGPEKYDKSCDMWSLG-VIMYILLCGYP 261 T Y++ LG E+ + D+ +LG + MY L P Sbjct: 175 TARYMSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLP 211 >5U6B-A nrPDB Length = 307 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 51/223 (22%), Positives = 97/223 (43%), Gaps = 33/223 (14%) Query: 56 KNAIIDDYKVT-SQVLGLGINGKVL--QIFNKRTQEKFALKMLQDCPKARREVELHWRAS 112 ++ ++D +KV + LG G G V+ Q+ + K A+K ++ R E+E + Sbjct: 16 RDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEA 75 Query: 113 QC------PHIVRIVDVYENLYAG--RKCL---LIVMECLDGGEL-----FSRIQDRGDQ 156 C P+++R++ V + G R+ ++++ + G+L +SR+ GDQ Sbjct: 76 VCMKEFDHPNVMRLIGV---CFQGSERESFPAPVVILPFMKHGDLHSFLLYSRL---GDQ 129 Query: 157 --AFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET 214 + + M I ++YL + HRD+ N + N + + DFG +K+ Sbjct: 130 PVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNE---NMSVCVADFGLSKKI 186 Query: 215 TSHNSLTTPCYTPY---YVAPEVLGPEKYDKSCDMWSLGVIMY 254 + + ++A E L Y D+WS GV M+ Sbjct: 187 YNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMW 229 >1AD5-A nrPDB Length = 438 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 38/152 (25%), Positives = 63/152 (41%), Gaps = 27/152 (17%) Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYY 229 I E + ++ N HRD++ N+L ++ + + K+ DFG A+ + + Sbjct: 287 IAEGMAFIEQRNYIHRDLRAANILVSA---SLVCKIADFGLAR--------VGAKFPIKW 335 Query: 230 VAPEVLGPEKYDKSCDMWSLGV-IMYILLCGYPPFYSNHGLAISPGMKT----RIRMGQY 284 APE + + D+WS G+ +M I+ G P+ PGM R Y Sbjct: 336 TAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPY---------PGMSNPEVIRALERGY 386 Query: 285 EFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTI 316 P PE EE+ ++ K P +R T Sbjct: 387 RMPRPE--NCPEELYNIMMRCWKNRPEERPTF 416 >6FEX-A nrPDB Length = 321 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 25/103 (24%), Positives = 48/103 (46%), Gaps = 8/103 (7%) Query: 166 IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY 225 + I ++YL ++N HRD+ N L N +K+ DFG ++ + + Sbjct: 148 VAAQIASGMRYLATLNFVHRDLATRNCLVGE---NFTIKIADFGMSRNLYAGDYYRVQGR 204 Query: 226 TPY---YVAPEVLGPEKYDKSCDMWSLGVIMY--ILLCGYPPF 263 ++A E + K+ + D+W+ GV ++ ++LC PF Sbjct: 205 AVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPF 247 >5HLW-A nrPDB Length = 299 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 36/135 (26%), Positives = 65/135 (48%), Gaps = 10/135 (7%) Query: 135 LIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLY 194 L+V+ + G+L + I++ T ++ + + ++YL S HRD+ N + Sbjct: 98 LVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCML 156 Query: 195 TSKRPNAILKLTDFGFA-----KETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSL 249 K +K+ DFG A KE S ++ T ++A E L +K+ D+WS Sbjct: 157 DEK---FTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSF 213 Query: 250 GVIMYILLC-GYPPF 263 GV+++ L+ G PP+ Sbjct: 214 GVLLWELMTRGAPPY 228 >4NEU-A nrPDB Length = 333 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 37/144 (25%), Positives = 63/144 (43%), Gaps = 21/144 (14%) Query: 136 IVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT 195 +VME ++ G L ++ + + I+ I E + YLH + H+D+KPEN+L Sbjct: 99 LVMEYMEKGNLMHVLKAEMSTPLSVK--GRIILEIIEGMCYLHGKGVIHKDLKPENILVD 156 Query: 196 SKRPNAILKLTDFGFAK-------ETTSHNSL-------TTPCYTPYYVAPEVLGP--EK 239 + + +K+ D G A HN L T YY+APE L K Sbjct: 157 N---DFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAK 213 Query: 240 YDKSCDMWSLGVIMYILLCGYPPF 263 + D++S V+++ + P+ Sbjct: 214 PTEKSDVYSFAVVLWAIFANKEPY 237 >6BSD-A nrPDB Length = 876 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 25/103 (24%), Positives = 48/103 (46%), Gaps = 8/103 (7%) Query: 166 IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY 225 + I ++YL ++N HRD+ N L N +K+ DFG ++ + + Sbjct: 709 VAAQIASGMRYLATLNFVHRDLATRNCLVGE---NFTIKIADFGMSRNLYAGDYYRVQGR 765 Query: 226 TPY---YVAPEVLGPEKYDKSCDMWSLGVIMY--ILLCGYPPF 263 ++A E + K+ + D+W+ GV ++ ++LC PF Sbjct: 766 AVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPF 808 >4XHH-A nrPDB Length = 403 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 28/96 (29%), Positives = 43/96 (44%), Gaps = 15/96 (15%) Query: 174 IQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPE 233 +QY+H + HRD+KP+N L R + + + DFG +K+ N T + PY Sbjct: 116 VQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFN---THRHIPYRENKS 172 Query: 234 VLGPEKY-----------DKSCDMWSLGVIMYILLC 258 + G +Y + D+ SLG M I C Sbjct: 173 LTGTARYASVNTHLGIEQSRRDDLESLGY-MLIYFC 207 >3PP0-A nrPDB Length = 338 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 54/216 (25%), Positives = 101/216 (46%), Gaps = 36/216 (16%) Query: 68 QVLGLGINGKVLQIF----NKRTQEKFALKMLQD--CPKARREV--ELHWRAS-QCPHIV 118 +VLG G G V + + + A+K+L++ PKA +E+ E + A P++ Sbjct: 23 KVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVS 82 Query: 119 RIVDVYENLYAGRKCLL----IVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 R++ + CL +V + + G L +++ + ++ + M+ I + + Sbjct: 83 RLLGI---------CLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQ-IAKGM 132 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK-----ETTSH-NSLTTPCYTPY 228 YL + + HRD+ N+L K PN + K+TDFG A+ ET H + P Sbjct: 133 SYLEDVRLVHRDLAARNVLV--KSPNHV-KITDFGLARLLDIDETEYHADGGKVPI---K 186 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPF 263 ++A E + ++ D+WS GV ++ L+ G P+ Sbjct: 187 WMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPY 222 >3ZZW-A nrPDB Length = 289 Score = 44.7 bits (104), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 28/107 (26%), Positives = 53/107 (49%), Gaps = 9/107 (8%) Query: 166 IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS---HNSLTT 222 ++ I ++YL S ++ H+D+ N+L K +K++D G +E + + L Sbjct: 133 LVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLN---VKISDLGLFREVYAADYYKLLGN 189 Query: 223 PCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPF--YSN 266 ++APE + K+ D+WS GV+++ + G P+ YSN Sbjct: 190 SLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSN 236 >6GQK-A nrPDB Length = 328 Score = 44.7 bits (104), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 35/155 (22%), Positives = 70/155 (45%), Gaps = 13/155 (8%) Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY- 228 + + + +L S N HRD+ N+L T I K+ DFG A++ + ++ Sbjct: 170 VAKGMAFLASKNCIHRDLAARNILLTHGN---ITKICDFGLARDIKNDSNYVDKGNARLP 226 Query: 229 --YVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYE 285 ++APE + Y D+WS G+ ++ L G P+ G+ + I+ G + Sbjct: 227 VKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPY---PGMPVDSKFYKMIKEG-FR 282 Query: 286 FPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM 320 +PE++ E+ +++ +P +R T + + Sbjct: 283 MSSPEYAPA--EMYDIMKTCWDADPDKRPTFKQIV 315 >3C1X-A nrPDB Length = 373 Score = 44.7 bits (104), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 35/135 (25%), Positives = 65/135 (48%), Gaps = 10/135 (7%) Query: 135 LIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLY 194 L+V+ + G+L + I++ T ++ + + +++L S HRD+ N + Sbjct: 167 LVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKFLASKKFVHRDLAARNCML 225 Query: 195 TSKRPNAILKLTDFGFA-----KETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSL 249 K +K+ DFG A KE S ++ T ++A E L +K+ D+WS Sbjct: 226 DEK---FTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSF 282 Query: 250 GVIMYILLC-GYPPF 263 GV+++ L+ G PP+ Sbjct: 283 GVLLWELMTRGAPPY 297 >5TOS-A nrPDB Length = 395 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 28/93 (30%), Positives = 50/93 (53%), Gaps = 8/93 (8%) Query: 172 EAIQYLHS--INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE--TTSHNSLTTPCYTP 227 + + +LHS + + +RD+K N+L + NA KL+DFG A++ + ++T Sbjct: 186 KGLAFLHSDPVKVIYRDIKASNILLDADY-NA--KLSDFGLARDGPMGDLSYVSTRVMGT 242 Query: 228 Y-YVAPEVLGPEKYDKSCDMWSLGVIMYILLCG 259 Y Y APE + + D++S GV++ +L G Sbjct: 243 YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 >2CHL-A nrPDB Length = 351 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 41/141 (29%), Positives = 64/141 (45%), Gaps = 21/141 (14%) Query: 136 IVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT 195 +V+E L G + D D+ F+ + I + ++Y+HS N+ +RDVKPEN L Sbjct: 103 MVLELL--GPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIG 160 Query: 196 --SKRPNAILKLTDFGFAKETTS-----------HNSLTTPCYTPYYVAPEV-LGPEKYD 241 + ++ + DF AKE H SLT T Y++ LG E+ Sbjct: 161 RPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTG---TARYMSINTHLGKEQ-S 216 Query: 242 KSCDMWSLG-VIMYILLCGYP 261 + D+ +LG + MY L P Sbjct: 217 RRDDLEALGHMFMYFLRGSLP 237 >3BBT-B nrPDB Length = 328 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 51/206 (24%), Positives = 89/206 (43%), Gaps = 29/206 (14%) Query: 68 QVLGLGINGKVLQIF----NKRTQEKFALKMLQDCPKARREVE-----LHWRASQCPHIV 118 +VLG G G V + + + A+K+L + + VE L + PH+V Sbjct: 21 KVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLV 80 Query: 119 RIVDVYENLYAGRKCL----LIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 R++ V CL +V + + G L + + D ++ + ++ I + + Sbjct: 81 RLLGV---------CLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQ-IAKGM 130 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCYTPY-YVA 231 YL + HRD+ N+L K PN + K+TDFG A+ E P ++A Sbjct: 131 MYLEERRLVHRDLAARNVLV--KSPNHV-KITDFGLARLLEGDEKEYNADGGKMPIKWMA 187 Query: 232 PEVLGPEKYDKSCDMWSLGVIMYILL 257 E + K+ D+WS GV ++ L+ Sbjct: 188 LECIHYRKFTHQSDVWSYGVTIWELM 213 >1CSN-A nrPDB Length = 298 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 55/249 (22%), Positives = 104/249 (41%), Gaps = 37/249 (14%) Query: 55 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM---LQDCPKARREVELHWRA 111 + N + YKV ++ G G G + + N ++ A+K D P+ R E + Sbjct: 4 QNNVVGVHYKVGRRI-GEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDEYRTYKLL 62 Query: 112 SQCPHIVRIVDVYENLYAGRKCL--LIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 169 + C I + Y G++ L ++V++ L G + D + F+ + + K Sbjct: 63 AGCTGIPNVY------YFGQEGLHNVLVIDLL--GPSLEDLLDLCGRKFSVKTVAMAAKQ 114 Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNA----ILKLTDFGFAKETTSHNSLTTPCY 225 + +Q +H ++ +RD+KP+N L RPN+ ++ + DFG K + T + Sbjct: 115 MLARVQSIHEKSLVYRDIKPDNFLIG--RPNSKNANMIYVVDFGMVK---FYRDPVTKQH 169 Query: 226 TPYYVAPEVLGPEKY-----------DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPG 274 PY + G +Y + D+ +LG + L G P+ GL + Sbjct: 170 IPYREKKNLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPW---QGLKAATN 226 Query: 275 MKTRIRMGQ 283 + R+G+ Sbjct: 227 KQKYERIGE 235 >6DBN-A nrPDB Length = 316 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 31/95 (32%), Positives = 47/95 (49%), Gaps = 13/95 (13%) Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK--ET-----TSHNSLTT 222 I + + YL S HRD+ N+L S+ +K+ DFG K ET T + + Sbjct: 149 ICKGMDYLGSRQYVHRDLAARNVLVESEHQ---VKIGDFGLTKAIETDKEYYTVKDDRDS 205 Query: 223 PCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILL 257 P + + APE L K+ + D+WS GV ++ LL Sbjct: 206 PVF---WYAPECLMQSKFYIASDVWSFGVTLHELL 237 >4XUF-A nrPDB Length = 297 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 25/98 (25%), Positives = 49/98 (50%), Gaps = 7/98 (7%) Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY- 228 + + +++L + HRD+ N+L T + ++K+ DFG A++ S ++ Sbjct: 145 VAKGMEFLEFKSCVHRDLAARNVLVTHGK---VVKICDFGLARDIMSDSNYVVRGNARLP 201 Query: 229 --YVAPEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPF 263 ++APE L Y D+WS G++++ I G P+ Sbjct: 202 VKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPY 239 >5GNK-A nrPDB Length = 297 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 97/213 (45%), Gaps = 30/213 (14%) Query: 68 QVLGLGINGKVLQIF----NKRTQEKFALKMLQDC--PKARREV--ELHWRAS-QCPHIV 118 +VLG G G V + ++ + A+K L++ PKA +E+ E + AS PH+ Sbjct: 25 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVC 84 Query: 119 RIVDVYENLYAGRKCLL----IVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 R++ + CL ++M+ + G L +++ D ++ + ++ I + + Sbjct: 85 RLLGI---------CLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQ-IAKGM 134 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--LTTPCYTPY-YVA 231 YL + HRD+ N+L K P + K+TDFG AK + P ++A Sbjct: 135 NYLEDRRLVHRDLAARNVLV--KTPQHV-KITDFGLAKLLGAEEKEYHAEGGKVPIKWMA 191 Query: 232 PEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPF 263 E + Y D+WS GV ++ L+ G P+ Sbjct: 192 LESILHRIYTHQSDVWSYGVTVWELMTFGSKPY 224 >5WNO-A nrPDB Length = 330 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 32/127 (25%), Positives = 56/127 (44%), Gaps = 7/127 (5%) Query: 161 REASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFA---KETTSH 217 RE I +QYL + HRD+ N+L K+ N + ++TDFG + K Sbjct: 124 REQVLYCYQIASGMQYLEKQRVVHRDLATRNVLV--KKFNHV-EITDFGLSKILKHDADS 180 Query: 218 NSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPFYSNHGLAISPGMK 276 ++ + ++A E+ Y + D+W+ GV + I+ G P+ +I +K Sbjct: 181 ITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLK 240 Query: 277 TRIRMGQ 283 R+ Q Sbjct: 241 DGNRLSQ 247 >5X02-A nrPDB Length = 347 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 25/98 (25%), Positives = 49/98 (50%), Gaps = 7/98 (7%) Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY- 228 + + +++L + HRD+ N+L T + ++K+ DFG A++ S ++ Sbjct: 184 VAKGMEFLEFKSCVHRDLAARNVLVTHGK---VVKICDFGLARDIMSDSNYVVRGNARLP 240 Query: 229 --YVAPEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPF 263 ++APE L Y D+WS G++++ I G P+ Sbjct: 241 VKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPY 278 >4RT7-A nrPDB Length = 415 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 25/98 (25%), Positives = 49/98 (50%), Gaps = 7/98 (7%) Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY- 228 + + +++L + HRD+ N+L T + ++K+ DFG A++ S ++ Sbjct: 252 VAKGMEFLEFKSCVHRDLAARNVLVTHGK---VVKICDFGLARDIMSDSNYVVRGNARLP 308 Query: 229 --YVAPEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPF 263 ++APE L Y D+WS G++++ I G P+ Sbjct: 309 VKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPY 346 >3UIM-A nrPDB Length = 326 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 29/96 (30%), Positives = 43/96 (44%), Gaps = 8/96 (8%) Query: 173 AIQYLHSI---NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY--TP 227 + YLH I HRDVK N+L + + DFG AK ++ T T Sbjct: 143 GLAYLHDHCDPKIIHRDVKAANILLDEEFEAVV---GDFGLAKLMDYKDTHVTTAVRGTI 199 Query: 228 YYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPF 263 ++APE L K + D++ GV++ L+ G F Sbjct: 200 GHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQRAF 235 >1LUF-A nrPDB Length = 343 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 28/122 (22%), Positives = 51/122 (41%), Gaps = 7/122 (5%) Query: 148 SRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTD 207 +R+ G + E I + + + YL HRD+ N L N ++K+ D Sbjct: 161 ARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGE---NMVVKIAD 217 Query: 208 FGFAKETTSHNSLTTPCYTPY---YVAPEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPF 263 FG ++ S + ++ PE + +Y D+W+ GV+++ I G P+ Sbjct: 218 FGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPY 277 Query: 264 YS 265 Y Sbjct: 278 YG 279 >6EQI-C nrPDB Length = 433 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 40/154 (25%), Positives = 67/154 (43%), Gaps = 30/154 (19%) Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNA--ILKLTDFGFAKETTSHNSLTTPCYTP-- 227 EA+ +++ NI+HRD+K +N+L +A + +TDFG N L P + Sbjct: 178 EAVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCL-CDKQNGLVIPYRSEDQ 236 Query: 228 ------YYVAPEVLGPE-------KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPG 274 +APE+ + Y KS D+W++G I Y + PFY +S Sbjct: 237 DKGGNRALMAPEIANAKPGTFSWLNYKKS-DLWAVGAIAYEIFNIDNPFYDKTMKLLSKS 295 Query: 275 MKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKT 308 K + + P E+ + + +IRNL+ Sbjct: 296 YK------EEDLP-----ELPDTIPFIIRNLVSN 318 >4M66-A nrPDB Length = 325 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 37/138 (26%), Positives = 64/138 (46%), Gaps = 22/138 (15%) Query: 141 LDGGELFSRIQDRGDQA-FTEREA-------SEIMKSIGEAIQYLHSIN--IAHRDVKPE 190 + G L +R + G A + EA +++ + + YLHS++ + HRD+KP Sbjct: 88 VSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGMCYLHSLDPPLLHRDLKPS 147 Query: 191 NLLYTSKRPNAILKLTDFGFA-------KETTSHNSLTTPCYTPYYVAPEVLGPE--KYD 241 N+L P KL DFG + + S + T Y+ PE+L K Sbjct: 148 NILLD---PELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDPELLFKVNLKAS 204 Query: 242 KSCDMWSLGVIMYILLCG 259 K+ D++S G++++ +L G Sbjct: 205 KASDVYSFGILVWAVLAG 222 >3REP-A nrPDB Length = 271 Score = 41.6 bits (96), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 36/174 (20%), Positives = 73/174 (41%), Gaps = 16/174 (9%) Query: 144 GELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN-IAHRDVKPENLLYTSKRPNAI 202 G L++ + + + + +A + + + +LH++ + R + + A Sbjct: 94 GSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTAR 153 Query: 203 LKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYD---KSCDMWSLGVIMYILLCG 259 + + D F+ ++ Y P +VAPE L + D +S DMWS V+++ L+ Sbjct: 154 ISMADVKFSFQSPGR------MYAPAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTR 207 Query: 260 YPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQR 313 PF + I GMK + + P +S V L++ + +P +R Sbjct: 208 EVPFADLSNMEI--GMKVALEGLRPTIP----PGISPHVSKLMKICMNEDPAKR 255 >1FVR-A nrPDB Length = 327 Score = 41.6 bits (96), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 25/96 (26%), Positives = 43/96 (44%), Gaps = 4/96 (4%) Query: 169 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY 228 + + YL HRD+ N+L N + K+ DFG ++ + T Sbjct: 150 DVARGMDYLSQKQFIHRDLAARNILVGE---NYVAKIADFGLSRGQEVYVKKTMGRLPVR 206 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMY-ILLCGYPPF 263 ++A E L Y + D+WS GV+++ I+ G P+ Sbjct: 207 WMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPY 242 >3LZB-A nrPDB Length = 327 Score = 41.2 bits (95), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 53/213 (24%), Positives = 96/213 (45%), Gaps = 30/213 (14%) Query: 68 QVLGLGINGKVLQIF----NKRTQEKFALKMLQDC--PKARREV--ELHWRAS-QCPHIV 118 +VLG G G V + ++ + A+K L++ PKA +E+ E + AS PH+ Sbjct: 21 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVC 80 Query: 119 RIVDVYENLYAGRKCLL----IVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 R++ + CL ++ + + G L +++ D ++ + ++ I + + Sbjct: 81 RLLGI---------CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQ-IAKGM 130 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--LTTPCYTPY-YVA 231 YL + HRD+ N+L K P + K+TDFG AK + P ++A Sbjct: 131 NYLEDRRLVHRDLAARNVLV--KTPQHV-KITDFGLAKLLGAEEKEYHAEGGKVPIKWMA 187 Query: 232 PEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPF 263 E + Y D+WS GV ++ L+ G P+ Sbjct: 188 LESILHRIYTHQSDVWSYGVTVWELMTFGSKPY 220 >6FER-A nrPDB Length = 309 Score = 41.2 bits (95), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 25/99 (25%), Positives = 46/99 (46%), Gaps = 8/99 (8%) Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN--SLTTPCYTP 227 I ++YL S+N HRD+ N L N +K+ DFG ++ S + + P Sbjct: 142 IASGMKYLSSLNFVHRDLATRNCLVG---KNYTIKIADFGMSRNLYSGDYYRIQGRAVLP 198 Query: 228 Y-YVAPEVLGPEKYDKSCDMWSLGVIMY--ILLCGYPPF 263 +++ E + K+ + D+W+ GV ++ C P+ Sbjct: 199 IRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPY 237 >4IX6-A nrPDB Length = 350 Score = 41.2 bits (95), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 25/78 (32%), Positives = 36/78 (46%), Gaps = 15/78 (19%) Query: 134 LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL 193 L M C D EL T++ E++ S+ LH + HRDVKP NL+ Sbjct: 130 LATAMACADATEL----------GVTKKAMRELLGSLAR----LHECGVVHRDVKPANLI 175 Query: 194 YTSKRPNAILKLTDFGFA 211 +++ +LKL D G A Sbjct: 176 -AAEKDGGVLKLIDLGAA 192 >4LRM-A nrPDB Length = 334 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 55/219 (25%), Positives = 97/219 (44%), Gaps = 39/219 (17%) Query: 68 QVLGLGINGKVLQIF----NKRTQEKFALKMLQDC--PKARREV--ELHWRAS----QCP 115 +VLG G G V + ++ + A+K L++ PKA +E+ E + AS P Sbjct: 25 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNP 84 Query: 116 HIVRIVDVYENLYAGRKCLL----IVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 H+ R++ + CL ++ + + G L +++ D ++ + ++ I Sbjct: 85 HVCRLLGI---------CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQ-IA 134 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK-----ETTSH-NSLTTPCY 225 + + YL + HRD+ N+L K P + K+TDFG AK E H P Sbjct: 135 KGMNYLEDRRLVHRDLAARNVLV--KTPQHV-KITDFGLAKLLGAEEKEYHAEGGKVPI- 190 Query: 226 TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPF 263 ++A E + Y D+WS GV ++ L+ G P+ Sbjct: 191 --KWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPY 227 >3PLS-A nrPDB Length = 298 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 30/128 (23%), Positives = 51/128 (39%), Gaps = 14/128 (10%) Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY- 228 + ++YL HRD+ N + + +K+ DFG A++ + + Sbjct: 133 VARGMEYLAEQKFVHRDLAARNCMLDE---SFTVKVADFGLARDILDREYYSVQQHRHAR 189 Query: 229 ----YVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQ 283 + A E L ++ D+WS GV+++ LL G PP+ I P T Sbjct: 190 LPVKWTALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRH-----IDPFDLTHFLAQG 244 Query: 284 YEFPNPEW 291 P PE+ Sbjct: 245 RRLPQPEY 252 >5X18-A nrPDB Length = 295 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 37/151 (24%), Positives = 71/151 (47%), Gaps = 20/151 (13%) Query: 128 YAGRKCL--LIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHR 185 Y G++ L ++V++ L G + D + F+ + ++ + I+ LH+ ++ +R Sbjct: 70 YFGQEGLHNILVIDLL--GPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHAHDLIYR 127 Query: 186 DVKPENLLYTS-KRPNA-ILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY--- 240 D+KP+N L +P+A + L DFG AK+ + T + PY + G +Y Sbjct: 128 DIKPDNFLIGRPGQPDANNIHLIDFGMAKQ---YRDPKTKQHIPYREKKSLSGTARYMSI 184 Query: 241 --------DKSCDMWSLGVIMYILLCGYPPF 263 + DM +LG + + L G+ P+ Sbjct: 185 NTHLGREQSRRDDMEALGHVFFYFLRGHLPW 215 >4JRN-A nrPDB Length = 372 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 44/171 (25%), Positives = 73/171 (42%), Gaps = 32/171 (18%) Query: 154 GDQAFTEREASEIMKSI--GEAIQYLHSI---NIAHRDVKPENLLYTSKRPNAILKLTDF 208 GD + + E +++ +AI+ + ++ I H D+KP N L + L L DF Sbjct: 190 GDASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLK---DGRLFLGDF 246 Query: 209 GFAKETTSHNSLTTPCYTPYYVAPE----VLGPEKYDKSCDMWSLGVIMYILLCGYPPFY 264 G + +NS+ TP Y PE G Y D W LG+ +Y + C P Sbjct: 247 GTYR---INNSVGRAIGTPGYEPPERPFQATGI-TYTFPTDAWQLGITLYCIWCKERPTP 302 Query: 265 SNHGLAISPGMKTRIRMGQYEFPN-PEWSEVSEEVKMLIRNLLKTEPTQRM 314 ++ G +++ + + E V+ LIR+LL +P +RM Sbjct: 303 AD---------------GIWDYLHFADCPSTPELVQDLIRSLLNRDPQKRM 338 >5CLR-A nrPDB Length = 451 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 48/219 (21%), Positives = 89/219 (40%), Gaps = 34/219 (15%) Query: 162 EASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT 221 E IM S+ ++ H + + HRD+KP N++ + L DFG ++S + Sbjct: 177 EVLGIMISVCHQVKQFHELGLIHRDLKPGNIMLDADMQ---CHLVDFG----SSSSDKEP 229 Query: 222 TPCY--TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRI 279 P T Y+APE+ E + + L + Y L + PF + G+K Sbjct: 230 KPASWGTASYLAPELNAQEDFIAFSQVSDLFALAYSLDELFNPFRQVKFAKVDIGIK--- 286 Query: 280 RMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQT----- 334 N + E++ I L+ E + R + I+Q +VP++ Sbjct: 287 --------NKHLVLLHAEIEACITGLMSNETSVRT-----LYFSRILQLQRVPESFKSRP 333 Query: 335 --PLHTSRVLKEDKERWE--DVKEEMTSALATMRVDYEQ 369 + +L + K +E ++ +E+ +A ++V YE Sbjct: 334 EAFTYLIMLLTQWKSCYEAPEMNKELDEIIAEIKVAYEN 372 >5C01-A nrPDB Length = 342 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 39/155 (25%), Positives = 61/155 (39%), Gaps = 19/155 (12%) Query: 166 IMKSIGEAIQYLHSINIAHRDVKPENLLYT----SKRPNAILKLTDFGFAKETTSHNSLT 221 + + + A+ YL + N+ H +V N+L ++ + +KL+D G S Sbjct: 185 VAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERV 244 Query: 222 TPCYTPYYVAPEVL--GPEKYDKSCDMWSLG-VIMYILLCGYPPFYSNHGLAISPGMKTR 278 P ++APE L G + D W G ++ I G P S SP K Sbjct: 245 E--RIP-WLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSR-----SPSEKEH 296 Query: 279 IRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQR 313 Q+ P P +++ L L EPTQR Sbjct: 297 FYQRQHRLPEPSCPQLA----TLTSQCLTYEPTQR 327 >4WOV-A nrPDB Length = 317 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 39/155 (25%), Positives = 61/155 (39%), Gaps = 19/155 (12%) Query: 166 IMKSIGEAIQYLHSINIAHRDVKPENLLYT----SKRPNAILKLTDFGFAKETTSHNSLT 221 + + + A+ YL + N+ H +V N+L ++ + +KL+D G S Sbjct: 162 VAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERV 221 Query: 222 TPCYTPYYVAPEVL--GPEKYDKSCDMWSLG-VIMYILLCGYPPFYSNHGLAISPGMKTR 278 P ++APE L G + D W G ++ I G P S SP K Sbjct: 222 E--RIP-WLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSR-----SPSEKEH 273 Query: 279 IRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQR 313 Q+ P P +++ L L EPTQR Sbjct: 274 FYQRQHRLPEPSCPQLA----TLTSQCLTYEPTQR 304 >3G2F-A nrPDB Length = 336 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 40/165 (24%), Positives = 68/165 (41%), Gaps = 32/165 (19%) Query: 116 HIVRIVDVYENLYA-GRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 +I R + E + A GR L+VME G L + + + + S+ + Sbjct: 68 NIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVS---SCRLAHSVTRGL 124 Query: 175 QYLHSI---------NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSH-------- 217 YLH+ I+HRD+ N+L + + ++DFG + T + Sbjct: 125 AYLHTELPRGDHYKPAISHRDLNSRNVLV---KNDGTCVISDFGLSMRLTGNRLVRPGEE 181 Query: 218 -NSLTTPCYTPYYVAPEVLGPEKYDKSC-------DMWSLGVIMY 254 N+ + T Y+APEVL + C DM++LG+I + Sbjct: 182 DNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYW 226 >3SOC-A nrPDB Length = 322 Score = 38.1 bits (87), Expect = 0.007, Method: Compositional matrix adjust. Identities = 30/113 (26%), Positives = 51/113 (45%), Gaps = 21/113 (18%) Query: 162 EASEIMKSIGEAIQYLHSI----------NIAHRDVKPENLLYTSKRPNAILKLTDFGFA 211 E I +++ + YLH I+HRD+K +N+L + N + DFG A Sbjct: 122 ELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLL---KNNLTACIADFGLA 178 Query: 212 ---KETTSHNSLTTPCYTPYYVAPEVL-GPEKYDKSC----DMWSLGVIMYIL 256 + S T Y+APEVL G + + DM+++G++++ L Sbjct: 179 LKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWEL 231 >3Q4U-A nrPDB Length = 301 Score = 37.4 bits (85), Expect = 0.010, Method: Compositional matrix adjust. Identities = 32/108 (29%), Positives = 50/108 (46%), Gaps = 22/108 (20%) Query: 166 IMKSIGEAIQYLH--------SINIAHRDVKPENLLYTSKRPNAILKLTDFGFA-KETTS 216 I+ SI + +LH IAHRD+K +N+L + N + D G A + S Sbjct: 110 IVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILV---KKNGQCCIADLGLAVMHSQS 166 Query: 217 HNSLTTP----CYTPYYVAPEVLGP----EKYD--KSCDMWSLGVIMY 254 N L T Y+APEVL + +D K D+W+ G++++ Sbjct: 167 TNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLW 214 >2QLU-A nrPDB Length = 314 Score = 37.4 bits (85), Expect = 0.011, Method: Compositional matrix adjust. Identities = 35/142 (24%), Positives = 59/142 (41%), Gaps = 37/142 (26%) Query: 146 LFSRIQDRGD-------QAFTEREASEIMKSIGEAIQYLHSI-----------NIAHRDV 187 L + D+G T E + +++ + YLH +IAHRD Sbjct: 90 LITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDF 149 Query: 188 KPENLLYTSKRPNAILKLTDFGFAKE-------TTSHNSLTTPCYTPYYVAPEVL-GPEK 239 K +N+L S + L DFG A +H + T Y+APEVL G Sbjct: 150 KSKNVLLKS---DLTAVLADFGLAVRFEPGKPPGDTHGQVG----TRRYMAPEVLEGAIN 202 Query: 240 YDKSC----DMWSLGVIMYILL 257 + + DM+++G++++ L+ Sbjct: 203 FQRDAFLRIDMYAMGLVLWELV 224 >2LAV-A nrPDB Length = 361 Score = 37.0 bits (84), Expect = 0.014, Method: Compositional matrix adjust. Identities = 20/82 (24%), Positives = 39/82 (47%), Gaps = 3/82 (3%) Query: 130 GRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKP 189 G+ ++M+ G +I + + F+ + ++ I + ++Y+H H D+K Sbjct: 123 GKSYRFMIMDRF--GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 180 Query: 190 ENLLYTSKRPNAILKLTDFGFA 211 NLL K P+ + L D+G A Sbjct: 181 SNLLLNYKNPDQVY-LVDYGLA 201 >2RSV-A nrPDB Length = 403 Score = 37.0 bits (84), Expect = 0.016, Method: Compositional matrix adjust. Identities = 20/82 (24%), Positives = 39/82 (47%), Gaps = 3/82 (3%) Query: 130 GRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKP 189 G+ ++M+ G +I + + F+ + ++ I + ++Y+H H D+K Sbjct: 130 GKSYRFMIMDRF--GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 187 Query: 190 ENLLYTSKRPNAILKLTDFGFA 211 NLL K P+ + L D+G A Sbjct: 188 SNLLLNYKNPDQVY-LVDYGLA 208 >5XD6-A nrPDB Length = 305 Score = 36.6 bits (83), Expect = 0.019, Method: Compositional matrix adjust. Identities = 27/104 (25%), Positives = 44/104 (42%), Gaps = 9/104 (8%) Query: 165 EIMKSIGEAIQYLHSI---NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET---TSHN 218 +I ++YLH ++ HRD+K N+L + + K+ DF + + + Sbjct: 130 KIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFD---DDVAKIADFDLSNQAPDMAARL 186 Query: 219 SLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPP 262 T T Y APE D++S GV++ LL G P Sbjct: 187 HSTRVLGTFGYHAPEYAMTGTLSTKSDVYSFGVVLLELLTGRKP 230 >6BHC-A nrPDB Length = 438 Score = 36.6 bits (83), Expect = 0.019, Method: Compositional matrix adjust. Identities = 42/178 (23%), Positives = 77/178 (43%), Gaps = 28/178 (15%) Query: 160 EREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAI----------------- 202 ER+ ++ + +++L ++ H D++ ENLL +P Sbjct: 177 ERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLLVHYQPGGTAQGFGPAEPTPTSSYPT 236 Query: 203 -LKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYP 261 L +++F AK+ SH +APE++ +Y K CD + G+++Y +L Sbjct: 237 RLIVSNFSQAKQ-KSHLVDPEILRDQSRLAPEIITATQY-KKCDEFQTGILIYEMLHLPN 294 Query: 262 PFYSNHGLAISPGMKTRIRMGQYEFPN-PEWSEVSEEVKMLIRNLLKTEPTQRMTITE 318 PF N P +K R + + P P S S ++ L LL P++R+ I++ Sbjct: 295 PFDEN------PELKER-EYTRADLPRIPFRSPYSRGLQQLASCLLNPNPSERILISD 345 >3LMG-A nrPDB Length = 344 Score = 36.6 bits (83), Expect = 0.022, Method: Compositional matrix adjust. Identities = 43/164 (26%), Positives = 70/164 (42%), Gaps = 14/164 (8%) Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRI-QDRGDQAFTEREASEIMKSIGEAI 174 HIVR++ + L +V + L G L + Q RG A + I + + Sbjct: 94 HIVRLLGLCPG-----SSLQLVTQYLPLGSLLDHVRQHRG--ALGPQLLLNWGVQIAKGM 146 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET--TSHNSLTTPCYTPY-YVA 231 YL + HR++ N+L K P+ + ++ DFG A L + TP ++A Sbjct: 147 YYLEEHGMVHRNLAARNVLL--KSPSQV-QVADFGVADLLPPDDKQLLYSEAKTPIKWMA 203 Query: 232 PEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGM 275 E + KY D+WS GV ++ L+ Y+ LA P + Sbjct: 204 LESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDL 247 >2WTK-B nrPDB Length = 373 Score = 35.8 bits (81), Expect = 0.038, Method: Compositional matrix adjust. Identities = 28/117 (23%), Positives = 52/117 (44%), Gaps = 13/117 (11%) Query: 157 AFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL--------YTSKRPNAILKLTDF 208 E + I++ + +A+ Y+H + HR VK ++L + R N L + Sbjct: 108 GMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSN--LSMISH 165 Query: 209 GFAKETTSHNSLTTPCYTPYYVAPEVL--GPEKYDKSCDMWSLGVIMYILLCGYPPF 263 G ++ H+ +++PEVL + YD D++S+G+ L G+ PF Sbjct: 166 G-QRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPF 221 >5X1R-A nrPDB Length = 302 Score = 35.4 bits (80), Expect = 0.049, Method: Compositional matrix adjust. Identities = 27/95 (28%), Positives = 43/95 (45%), Gaps = 9/95 (9%) Query: 173 AIQYLHSINIAHRDVKPENL-LYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVA 231 AI +H HRD+ +N+ + S+ P L DFG A++ + S T A Sbjct: 152 AINTIHQEGYLHRDISLDNIQIQESQLP----VLLDFGSARKEIGNLSDETEIVLKPGFA 207 Query: 232 PEVLGPEKYDKS----CDMWSLGVIMYILLCGYPP 262 P E D D+++LG +++ L+ G PP Sbjct: 208 PIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP 242 >4OAU-C nrPDB Length = 699 Score = 35.0 bits (79), Expect = 0.055, Method: Compositional matrix adjust. Identities = 49/192 (25%), Positives = 78/192 (40%), Gaps = 30/192 (15%) Query: 30 HPPAQPPPPPPQQF----PQFH-VKSGLQIKKNAIIDD-YKVTSQVLGLGINGKVLQIFN 83 HPPA+ P + H + + K ID+ YK+ G G L + Sbjct: 310 HPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEG----GIYLGFYE 365 Query: 84 KRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVME---- 139 K QE + P+A+REV + + H+V + C+ + + Sbjct: 366 K--QEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEA 423 Query: 140 CLDGGELFSRIQDRGDQAFTERE--ASEIMKSIGEAIQYLH-SINIAHRDVKPENLLYTS 196 CLD RG+ E + A ++ SI +A+Q LH S H+D++P+N+L S Sbjct: 424 CLD--------VHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDS 475 Query: 197 KRPNAILKLTDF 208 K+ L DF Sbjct: 476 KKA---AHLADF 484 >2X7G-A nrPDB Length = 389 Score = 35.0 bits (79), Expect = 0.055, Method: Compositional matrix adjust. Identities = 23/78 (29%), Positives = 38/78 (48%), Gaps = 2/78 (2%) Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 +V+++D ++ + +V E L G L I Q R I++ + + + Y Sbjct: 97 VVQLIDDFKISGMNGIHVCMVFEVL-GHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDY 155 Query: 177 LHS-INIAHRDVKPENLL 193 LHS I H D+KPEN+L Sbjct: 156 LHSKCKIIHTDIKPENIL 173 >6G4J-A nrPDB Length = 315 Score = 35.0 bits (79), Expect = 0.056, Method: Compositional matrix adjust. Identities = 51/212 (24%), Positives = 84/212 (39%), Gaps = 20/212 (9%) Query: 48 VKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVEL 107 +K G IK + Y + Q LG G NG V + + ALK+ D EV + Sbjct: 13 LKPGTTIKGKWNGNTYTLRKQ-LGKGANGIVY--LAETSDGHVALKVSDDSLSITSEVNV 69 Query: 108 HWRASQCPHIVRIVDVYE--NLY---AGRKCLLIVMECLDGGELFSRIQDRGDQAFTERE 162 S+ + ++ + Y A K ME + G L + D+G + Sbjct: 70 LKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGAEWI---- 125 Query: 163 ASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTT 222 +M + ++ LH D+KP+NL+ T P A ++ D G T+ Sbjct: 126 -PVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTG--PPARIRCIDVG----GTTKEGRAI 178 Query: 223 PCYTPYY-VAPEVLGPEKYDKSCDMWSLGVIM 253 YT +Y G K + S D++++ +IM Sbjct: 179 KEYTEFYDRGYWGYGTRKAEPSYDLFAVAMIM 210 >4BTF-A nrPDB Length = 469 Score = 34.3 bits (77), Expect = 0.11, Method: Compositional matrix adjust. Identities = 44/206 (21%), Positives = 80/206 (38%), Gaps = 18/206 (8%) Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 P+I+RI + + IVME + G L + D + R S ++ + Sbjct: 254 PNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVR--SLLVLRAARGL 311 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK-----ETTSHNSLTTPCYTPYY 229 LH HR++ + L +KL F +K T+ ++ + Y Sbjct: 312 YRLHHSETLHRNISSSSFLVAGGYQ---VKLAGFELSKTQNSISRTAKSTKAERSSSTIY 368 Query: 230 VAPEVLGPE--KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 V+PE L YD +++S G++++ + G PF K R + + + Sbjct: 369 VSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEG------CDSKKIRELVAEDKKQ 422 Query: 288 NPEWSEVSEEVKMLIRNLLKTEPTQR 313 P + E ++ +I EP+QR Sbjct: 423 EPVGQDCPELLREIINECRAHEPSQR 448 >5UU1-A nrPDB Length = 324 Score = 34.3 bits (77), Expect = 0.11, Method: Compositional matrix adjust. Identities = 22/84 (26%), Positives = 40/84 (47%), Gaps = 4/84 (4%) Query: 128 YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDV 187 + GR +VME L G +I + + F + ++ + + ++Y+H H D+ Sbjct: 100 FKGRSYRFMVMERL--GIDLQKISGQ-NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDI 156 Query: 188 KPENLLYTSKRPNAILKLTDFGFA 211 K NLL K P+ + L D+G + Sbjct: 157 KAANLLLGYKNPDQVY-LADYGLS 179 >3MDY-A nrPDB Length = 337 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 27/85 (31%), Positives = 42/85 (49%), Gaps = 16/85 (18%) Query: 182 IAHRDVKPENLLYTSKRPNAILKLTDFGFA-KETTSHNSLTTP----CYTPYYVAPEVLG 236 IAHRD+K +N+L + N + D G A K + N + P T Y+ PEVL Sbjct: 163 IAHRDLKSKNILV---KKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVL- 218 Query: 237 PEKYDKS-------CDMWSLGVIMY 254 E +++ DM+S G+I++ Sbjct: 219 DESLNRNHFQSYIMADMYSFGLILW 243 >1PY5-A nrPDB Length = 326 Score = 33.9 bits (76), Expect = 0.12, Method: Compositional matrix adjust. Identities = 26/88 (29%), Positives = 41/88 (46%), Gaps = 22/88 (25%) Query: 182 IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTP--------CYTPYYVAPE 233 IAHRD+K +N+L + N + D G A H+S T T Y+APE Sbjct: 155 IAHRDLKSKNILV---KKNGTCCIADLGLA---VRHDSATDTIDIAPNHRVGTKRYMAPE 208 Query: 234 VLGP-------EKYDKSCDMWSLGVIMY 254 VL E + K D++++G++ + Sbjct: 209 VLDDSINMKHFESF-KRADIYAMGLVFW 235 >4M69-B nrPDB Length = 283 Score = 33.9 bits (76), Expect = 0.13, Method: Compositional matrix adjust. Identities = 44/206 (21%), Positives = 80/206 (38%), Gaps = 18/206 (8%) Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 P+I+RI + + IVME + G L + D + R S ++ + Sbjct: 68 PNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVR--SLLVLRAARGL 125 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK-----ETTSHNSLTTPCYTPYY 229 LH HR++ + L +KL F +K T+ ++ + Y Sbjct: 126 YRLHHSETLHRNISSSSFLVAG---GYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIY 182 Query: 230 VAPEVLGPE--KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 V+PE L YD +++S G++++ + G PF K R + + + Sbjct: 183 VSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEG------CDSKKIRELVAEDKKQ 236 Query: 288 NPEWSEVSEEVKMLIRNLLKTEPTQR 313 P + E ++ +I EP+QR Sbjct: 237 EPVGQDCPELLREIINECRAHEPSQR 262 >5AC0-A nrPDB Length = 501 Score = 33.1 bits (74), Expect = 0.20, Method: Compositional matrix adjust. Identities = 23/85 (27%), Positives = 38/85 (44%), Gaps = 9/85 (10%) Query: 74 INGKVLQIFNKRTQEKFALKMLQD-------CPKARREVELH--WRASQCPHIVRIVDVY 124 ++GK +FN T+EK D AR+ ++ WR R+++ Sbjct: 33 VSGKKFPVFNPATEEKLCEVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLNKL 92 Query: 125 ENLYAGRKCLLIVMECLDGGELFSR 149 +L + LL ME ++GG+LFS Sbjct: 93 ADLIERDRLLLATMEAMNGGKLFSN 117 >4O1O-A nrPDB Length = 717 Score = 33.1 bits (74), Expect = 0.20, Method: Compositional matrix adjust. Identities = 21/58 (36%), Positives = 31/58 (53%), Gaps = 5/58 (8%) Query: 153 RGDQAFTERE--ASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDF 208 RGD E + A I+ S+ +AI LH +H+D++P+N+L SK L DF Sbjct: 432 RGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTF---LADF 486 >3MY0-A nrPDB Length = 305 Score = 32.7 bits (73), Expect = 0.31, Method: Compositional matrix adjust. Identities = 26/85 (30%), Positives = 37/85 (43%), Gaps = 16/85 (18%) Query: 182 IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTP-----YYVAPEVLG 236 IAHRD K N+L S N + D G A + + P Y+APEVL Sbjct: 134 IAHRDFKSRNVLVKS---NLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLD 190 Query: 237 P-------EKYDKSCDMWSLGVIMY 254 E Y K D+W+ G++++ Sbjct: 191 EQIRTDCFESY-KWTDIWAFGLVLW 214 >3Q60-A nrPDB Length = 371 Score = 32.3 bits (72), Expect = 0.34, Method: Compositional matrix adjust. Identities = 40/173 (23%), Positives = 68/173 (39%), Gaps = 20/173 (11%) Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAP-EVL 235 L S + H P+NL P+ L L D + + ++ P AP E L Sbjct: 210 LQSKGLVHGHFTPDNLFIM---PDGRLMLGDVSALWKVGTRGPASS---VPVTYAPREFL 263 Query: 236 GPEK--YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE--- 290 + + + W LG+ +Y + C + PF GL ++PG+K + P + Sbjct: 264 NASTATFTHALNAWQLGLSIYRVWCLFLPF----GL-VTPGIKGSWKRPSLRVPGTDSLA 318 Query: 291 ---WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSR 340 + + + VK LI L + +R+ E M P +Q + L T + Sbjct: 319 FGSCTPLPDFVKTLIGRFLNFDRRRRLLPLEAMETPEFLQLQNEISSSLSTGQ 371 >5DMZ-A nrPDB Length = 365 Score = 32.3 bits (72), Expect = 0.38, Method: Compositional matrix adjust. Identities = 30/122 (24%), Positives = 48/122 (39%), Gaps = 20/122 (16%) Query: 174 IQYLHSINIAHRDVKPENLLYTS--------KRPNAILKLTDFG-------FAKETTSHN 218 I+ +H I H D+KP+N + + +A L L D G F K T Sbjct: 185 IEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTI--- 241 Query: 219 SLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISP-GMKT 277 T C T + E+L + ++ D + + +Y +L G N G P G+ Sbjct: 242 -FTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFR 300 Query: 278 RI 279 R+ Sbjct: 301 RL 302 >2JII-A nrPDB Length = 352 Score = 32.3 bits (72), Expect = 0.39, Method: Compositional matrix adjust. Identities = 42/197 (21%), Positives = 80/197 (40%), Gaps = 23/197 (11%) Query: 87 QEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYEN-LYAGRKCL----------L 135 ++KF+LK+ + E RA++ + + +Y L A C+ Sbjct: 75 KQKFSLKLDAKDGRLFNEQNFFQRAAKPLQVNKWKKLYSTPLLAIPTCMGFGVHQDKYRF 134 Query: 136 IVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT 195 +V+ L G L S + +ER ++ + +A+++LH H +V EN ++ Sbjct: 135 LVLPSL-GRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAEN-IFV 192 Query: 196 SKRPNAILKLTDFGFAKE---TTSHNSLTTPCYTPYYVAPEVLGPEKYDKSC------DM 246 + + L +GFA + H + +P+ E + + + K C D+ Sbjct: 193 DPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLH-KGCGPSRRSDL 251 Query: 247 WSLGVIMYILLCGYPPF 263 SLG M L G+ P+ Sbjct: 252 QSLGYCMLKWLYGFLPW 268 >4L00-A nrPDB Length = 304 Score = 31.6 bits (70), Expect = 0.68, Method: Compositional matrix adjust. Identities = 30/126 (23%), Positives = 53/126 (42%), Gaps = 11/126 (8%) Query: 135 LIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLY 194 ++V E ++GG L R T ++ K + A+ YL ++ H +V +NLL Sbjct: 108 IMVEEFVEGGPL-DLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLL 166 Query: 195 TSKRPNA----ILKLTDFGFAKETTSHNSLTTPCYTPY-YVAPEVLGPEK-YDKSCDMWS 248 + ++ +KL+D G S C ++APE + K + D WS Sbjct: 167 AREGIDSECGPFIKLSDPGIPITVLSRQE----CIERIPWIAPECVEDSKNLSVAADKWS 222 Query: 249 LGVIMY 254 G ++ Sbjct: 223 FGTTLW 228 >4WUA-A nrPDB Length = 401 Score = 30.8 bits (68), Expect = 0.95, Method: Compositional matrix adjust. Identities = 21/80 (26%), Positives = 39/80 (48%), Gaps = 2/80 (2%) Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 +V+++D ++ + +V E L G L I Q +I++ + + + Y Sbjct: 107 VVQLLDDFKISGVNGTHICMVFEVL-GHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDY 165 Query: 177 LHS-INIAHRDVKPENLLYT 195 LH+ I H D+KPEN+L + Sbjct: 166 LHTKCRIIHTDIKPENILLS 185 >4MWI-A nrPDB Length = 294 Score = 30.8 bits (68), Expect = 1.1, Method: Compositional matrix adjust. Identities = 36/160 (22%), Positives = 62/160 (38%), Gaps = 14/160 (8%) Query: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 + P+I+RI + + IVME + G L + D +R ++ Sbjct: 81 ESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRMV--LVLGAAR 138 Query: 173 AIQYLHSINI--AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYV 230 + LH H ++ N L T +KL F K TS + TT T Sbjct: 139 GLYRLHHSEAPELHGKIRSSNFLVTQ---GYQVKLAGFELRKTQTSMSLGTTREKTDRVK 195 Query: 231 APEVLGPE-------KYDKSCDMWSLGVIMYILLCGYPPF 263 + L P+ +YD +++S G++++ + G PF Sbjct: 196 STAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPF 235 >6DCE-A nrPDB Length = 101 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 17/71 (23%), Positives = 35/71 (49%), Gaps = 1/71 (1%) Query: 160 EREASEIMKSIGEAIQYLHSINIAHRDVKP-ENLLYTSKRPNAILKLTDFGFAKETTSHN 218 ER + ++ ++ + +LHS ++ D+KP E S+RP + K+ + + + + N Sbjct: 20 ERHDNYVLFTVSPTLYFLHSESLPALDLKPGEGASGASRRPWVLGKVMEKEYCQAKKAQN 79 Query: 219 SLTTPCYTPYY 229 P T +Y Sbjct: 80 RFKVPLGTKFY 90 >6GMA-A nrPDB Length = 140 Score = 30.4 bits (67), Expect = 1.4, Method: Compositional matrix adjust. Identities = 18/76 (23%), Positives = 36/76 (47%), Gaps = 1/76 (1%) Query: 160 EREASEIMKSIGEAIQYLHSINIAHRDVKP-ENLLYTSKRPNAILKLTDFGFAKETTSHN 218 ER + ++ ++ + +LHS ++ D+KP E S+RP + K+ + + + + N Sbjct: 59 ERHDNYVLFTVSPTLYFLHSESLPALDLKPGEGASGASRRPWVLGKVMEKEYCQAKKAQN 118 Query: 219 SLTTPCYTPYYVAPEV 234 P T +Y V Sbjct: 119 RFKVPLGTKFYRVKAV 134 >4UUD-B nrPDB Length = 864 Score = 30.4 bits (67), Expect = 1.5, Method: Compositional matrix adjust. Identities = 16/40 (40%), Positives = 21/40 (52%), Gaps = 1/40 (2%) Query: 7 GQSPPVPF-PAPAPPPQPPTPALPHPPAQPPPPPPQQFPQ 45 G +PPVP P +P P P P +P P + PP P + Q Sbjct: 810 GGAPPVPSRPGASPDPFGPPPQVPSRPNRAPPGVPSRSGQ 849 >3ENH-A nrPDB Length = 540 Score = 30.0 bits (66), Expect = 1.9, Method: Compositional matrix adjust. Identities = 20/77 (25%), Positives = 32/77 (41%), Gaps = 15/77 (19%) Query: 136 IVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT 195 I+M ++G I+D D A+ IGE + LH ++ H D+ N ++ Sbjct: 416 IMMSYINGKLAKDVIEDNLDIAY----------KIGEIVGKLHKNDVIHNDLTTSNFIFD 465 Query: 196 SKRPNAILKLTDFGFAK 212 L + DFG K Sbjct: 466 KD-----LYIIDFGLGK 477 >5UV4-A nrPDB Length = 311 Score = 29.6 bits (65), Expect = 2.7, Method: Compositional matrix adjust. Identities = 28/104 (26%), Positives = 48/104 (46%), Gaps = 17/104 (16%) Query: 166 IMKSIGEAIQYLHSINIA-HRDVKPENLLYTSKRPNAILK-------LTDFGFAKETTSH 217 I I + YLH+ + H ++K N+L + P+A++ +T G A++ + Sbjct: 133 IAIDIARCLDYLHNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNA 192 Query: 218 NSLTTPCYTPYYVAPEVLGPEKYDKS--CDMWSLGVIMYILLCG 259 +L Y+P PE K S D+++ GVI+ LL G Sbjct: 193 GALG---YSP----PEFSSTSKPCPSLKSDVYAFGVILLELLTG 229 >5AC2-A nrPDB Length = 501 Score = 28.1 bits (61), Expect = 7.0, Method: Compositional matrix adjust. Identities = 21/85 (24%), Positives = 37/85 (43%), Gaps = 9/85 (10%) Query: 74 INGKVLQIFNKRTQEKFALKMLQD-------CPKARREVELH--WRASQCPHIVRIVDVY 124 ++GK +FN T+E+ D AR+ ++ WR R++ Sbjct: 33 VSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKL 92 Query: 125 ENLYAGRKCLLIVMECLDGGELFSR 149 +L + LL ME ++GG+L+S Sbjct: 93 ADLIERDRLLLATMESMNGGKLYSN 117 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1NY3-A nrPDB 602 e-172 2OZA-A nrPDB 529 e-150 3KA0-A nrPDB 477 e-135 3FXW-A nrPDB 430 e-121 3M42-A nrPDB 430 e-121 5JN2-A nrPDB 371 e-103 3NCG-A nrPDB 361 e-100 3HZT-A nrPDB 344 3e-95 4MVF-A nrPDB 339 1e-93 3LIJ-A nrPDB 338 3e-93 4YZB-A nrPDB 336 1e-92 5U6Y-A nrPDB 331 4e-91 3SOA-A nrPDB 330 8e-91 2BDW-A nrPDB 330 8e-91 2VN9-A nrPDB 326 1e-89 2V7O-A nrPDB 323 8e-89 4RGJ-A nrPDB 322 2e-88 5FG8-A nrPDB 320 5e-88 4NIF-A nrPDB 319 2e-87 2W4O-A nrPDB 318 2e-87 3DFA-A nrPDB 318 3e-87 3MA6-A nrPDB 318 4e-87 3DXN-A nrPDB 318 4e-87 5IG1-A nrPDB 317 5e-87 3Q5I-A nrPDB 314 4e-86 2VZ6-A nrPDB 314 4e-86 3BHH-A nrPDB 314 5e-86 3KK8-A nrPDB 312 2e-85 2JAM-A nrPDB 312 2e-85 4FG9-A nrPDB 311 3e-85 2JC6-A nrPDB 311 4e-85 4JG6-A nrPDB 302 2e-82 3TAC-A nrPDB 297 7e-81 4REW-A nrPDB 297 7e-81 3KN6-A nrPDB 294 4e-80 4CFF-A nrPDB 294 4e-80 5EZV-A nrPDB 294 5e-80 4CFH-A nrPDB 294 5e-80 5WAX-A nrPDB 294 6e-80 2YCR-A nrPDB 293 8e-80 4RED-A nrPDB 292 1e-79 3F3Z-A nrPDB 292 2e-79 3I6U-A nrPDB 291 5e-79 3ZUT-A nrPDB 288 3e-78 2HW6-A nrPDB 287 8e-78 2X4F-A nrPDB 287 8e-78 2YAB-A nrPDB 286 1e-77 2J90-A nrPDB 284 4e-77 3UDB-A nrPDB 284 5e-77 5JZN-A nrPDB 284 5e-77 3UC3-A nrPDB 283 7e-77 5XZW-A nrPDB 283 8e-77 5YKS-A nrPDB 283 9e-77 6CKI-A nrPDB 282 1e-76 2A27-A nrPDB 282 1e-76 3GUB-A nrPDB 282 2e-76 1ZWS-A nrPDB 282 2e-76 1PHK-A nrPDB 281 4e-76 5ES1-A nrPDB 278 4e-75 2YZA-A nrPDB 278 4e-75 3H4J-B nrPDB 277 5e-75 2QNJ-A nrPDB 277 5e-75 2Y7J-A nrPDB 277 7e-75 3MN3-A nrPDB 276 2e-74 4CZT-A nrPDB 274 7e-74 3IS5-A nrPDB 273 8e-74 4PDS-A nrPDB 273 8e-74 5KZ7-A nrPDB 273 1e-73 4UZD-A nrPDB 271 4e-73 4CQG-A nrPDB 270 6e-73 6ED6-A nrPDB 270 8e-73 1KOB-A nrPDB 269 1e-72 3D2K-A nrPDB 268 3e-72 4D2V-A nrPDB 268 3e-72 3UTO-A nrPDB 268 4e-72 6E9W-A nrPDB 267 8e-72 4D28-A nrPDB 266 1e-71 5KCV-A nrPDB 266 2e-71 2JDO-A nrPDB 265 2e-71 3LM0-A nrPDB 265 2e-71 1KOA-A nrPDB 264 3e-71 3COM-A nrPDB 264 7e-71 4JXF-A nrPDB 263 8e-71 4YNZ-A nrPDB 263 1e-70 5N23-A nrPDB 262 2e-70 1FOT-A nrPDB 262 2e-70 3MV5-A nrPDB 261 3e-70 5X3F-B nrPDB 260 7e-70 4WB7-A nrPDB 259 1e-69 4FIE-A nrPDB 258 4e-69 6FDY-U nrPDB 257 4e-69 4LG4-A nrPDB 256 1e-68 6FD3-A nrPDB 255 3e-68 2HAK-A nrPDB 254 3e-68 3HDN-A nrPDB 254 4e-68 5D7A-A nrPDB 254 5e-68 4QMW-A nrPDB 254 5e-68 5DYK-A nrPDB 253 8e-68 3TXO-A nrPDB 253 1e-67 6AO5-A nrPDB 253 1e-67 6C9D-A nrPDB 253 1e-67 2BPM-A nrPDB 253 1e-67 6CMJ-A nrPDB 252 2e-67 4JDH-A nrPDB 252 3e-67 5FET-A nrPDB 251 4e-67 2UV2-A nrPDB 250 5e-67 5F9E-A nrPDB 249 1e-66 6DTL-A nrPDB 249 1e-66 5D9K-A nrPDB 248 2e-66 4KS7-A nrPDB 248 3e-66 1CM8-A nrPDB 248 3e-66 3NIZ-A nrPDB 248 3e-66 3DB8-A nrPDB 248 4e-66 4B6L-A nrPDB 248 4e-66 5AWM-A nrPDB 248 4e-66 4RA4-A nrPDB 248 4e-66 4FZF-B nrPDB 247 5e-66 2XIK-A nrPDB 247 6e-66 4J52-A nrPDB 247 7e-66 2OU7-A nrPDB 246 9e-66 5Z33-A nrPDB 246 1e-65 4L42-A nrPDB 246 1e-65 1TKI-A nrPDB 246 1e-65 4XBR-A nrPDB 246 1e-65 3Q53-A nrPDB 246 1e-65 4RLP-A nrPDB 246 1e-65 2Q0N-A nrPDB 246 2e-65 2F57-A nrPDB 245 2e-65 3HKO-A nrPDB 245 2e-65 4I6B-A nrPDB 245 2e-65 4AGU-A nrPDB 245 2e-65 2Z7Q-A nrPDB 245 2e-65 4B8L-A nrPDB 245 2e-65 1VZO-A nrPDB 244 4e-65 3NYO-A nrPDB 244 5e-65 3E7O-A nrPDB 244 6e-65 4TNB-A nrPDB 244 6e-65 5YV8-A nrPDB 244 8e-65 4MYG-A nrPDB 243 8e-65 4CSV-A nrPDB 243 1e-64 1G3N-A nrPDB 243 1e-64 3PFQ-A nrPDB 242 1e-64 3A8W-A nrPDB 242 3e-64 6BDL-A nrPDB 241 5e-64 4AF3-A nrPDB 240 5e-64 4UY9-A nrPDB 240 5e-64 2I0E-A nrPDB 240 8e-64 5NGU-A nrPDB 240 9e-64 5J5T-A nrPDB 239 1e-63 5VO2-A nrPDB 239 1e-63 1JNK-A nrPDB 239 2e-63 3TKU-A nrPDB 239 2e-63 3ORZ-A nrPDB 239 3e-63 4IC8-A nrPDB 238 3e-63 3DAK-A nrPDB 238 4e-63 2XS0-A nrPDB 237 6e-63 4QTB-A nrPDB 237 6e-63 4EWQ-A nrPDB 236 1e-62 6HXF-B nrPDB 236 1e-62 4BBM-A nrPDB 235 2e-62 6GU6-A nrPDB 235 2e-62 4AW2-A nrPDB 235 3e-62 4APC-A nrPDB 235 3e-62 3C51-A nrPDB 235 3e-62 6QAU-A nrPDB 235 3e-62 2F9G-A nrPDB 235 3e-62 4U41-A nrPDB 234 5e-62 3OHT-A nrPDB 233 1e-61 3OZ6-A nrPDB 233 1e-61 4WNO-A nrPDB 233 1e-61 2WQN-A nrPDB 232 2e-61 4YHJ-A nrPDB 232 2e-61 4QNY-A nrPDB 232 2e-61 5AIR-A nrPDB 232 2e-61 3FI2-A nrPDB 232 3e-61 4ZSG-A nrPDB 231 3e-61 6CCF-A nrPDB 231 5e-61 6E2O-A nrPDB 230 6e-61 3ZDU-A nrPDB 230 7e-61 5LOH-A nrPDB 230 8e-61 4KRC-A nrPDB 230 1e-60 5ZTN-A nrPDB 230 1e-60 4NST-A nrPDB 229 1e-60 2W96-B nrPDB 229 1e-60 5EFQ-A nrPDB 229 2e-60 4AU8-A nrPDB 229 2e-60 4BGQ-A nrPDB 228 3e-60 2XNP-A nrPDB 228 4e-60 5Y86-A nrPDB 227 5e-60 4C0T-A nrPDB 227 6e-60 3ALO-A nrPDB 227 6e-60 5DBX-A nrPDB 227 9e-60 3DTC-A nrPDB 226 1e-59 6GQK-A nrPDB 226 1e-59 2OZO-A nrPDB 225 2e-59 2BRG-A nrPDB 225 2e-59 1V0B-A nrPDB 225 2e-59 4UYA-A nrPDB 225 3e-59 3N9X-A nrPDB 225 4e-59 5O2B-A nrPDB 224 4e-59 6CQF-A nrPDB 224 5e-59 3GC9-A nrPDB 224 5e-59 4E7W-A nrPDB 224 5e-59 6BXI-A nrPDB 224 6e-59 1FVR-A nrPDB 224 8e-59 5O2C-A nrPDB 223 1e-58 5UUU-A nrPDB 222 1e-58 3V5Q-A nrPDB 222 3e-58 3PVW-A nrPDB 222 3e-58 4CRS-A nrPDB 221 3e-58 4OTD-A nrPDB 221 3e-58 4PWN-A nrPDB 221 4e-58 2VD5-A nrPDB 221 4e-58 4XEY-B nrPDB 221 4e-58 3TT0-A nrPDB 220 6e-58 2FO0-A nrPDB 220 7e-58 4FR4-A nrPDB 220 7e-58 1U5R-A nrPDB 220 1e-57 6NPU-A nrPDB 219 1e-57 3E3P-A nrPDB 219 1e-57 5KMM-A nrPDB 219 1e-57 4O2Z-A nrPDB 219 1e-57 5H2U-A nrPDB 219 1e-57 4GS6-A nrPDB 219 3e-57 3NIE-A nrPDB 218 3e-57 3GQL-A nrPDB 218 3e-57 5X8I-B nrPDB 218 4e-57 3CJF-A nrPDB 218 4e-57 5O0Y-A nrPDB 217 5e-57 4OLI-A nrPDB 217 5e-57 4AT3-A nrPDB 217 5e-57 2XYN-A nrPDB 217 6e-57 4E93-A nrPDB 217 7e-57 5A46-A nrPDB 217 7e-57 2OGV-A nrPDB 217 7e-57 2GCD-A nrPDB 217 7e-57 3RP9-A nrPDB 217 8e-57 3EB0-A nrPDB 217 8e-57 4XCU-A nrPDB 216 1e-56 5G6V-A nrPDB 216 1e-56 2PSQ-A nrPDB 216 1e-56 6DBM-A nrPDB 216 1e-56 3MIA-A nrPDB 216 2e-56 3BEA-A nrPDB 215 2e-56 2H8H-A nrPDB 215 3e-56 3KRL-A nrPDB 214 4e-56 1UA2-A nrPDB 214 5e-56 3G0E-A nrPDB 214 5e-56 3GC0-A nrPDB 214 6e-56 6F3F-A nrPDB 214 6e-56 3VN9-A nrPDB 214 6e-56 2WTK-C nrPDB 214 6e-56 2I6L-A nrPDB 214 8e-56 5X5O-A nrPDB 214 9e-56 4EBW-A nrPDB 213 9e-56 6FYV-A nrPDB 213 1e-55 3PPZ-A nrPDB 213 1e-55 5GRN-A nrPDB 213 1e-55 5EG3-A nrPDB 212 2e-55 4R7H-A nrPDB 212 2e-55 4P5Q-A nrPDB 212 2e-55 6HV0-A nrPDB 212 3e-55 5SYS-A nrPDB 212 3e-55 4PL5-B nrPDB 211 3e-55 4XLV-A nrPDB 211 4e-55 4E20-A nrPDB 211 5e-55 4H1J-A nrPDB 211 5e-55 3PG1-A nrPDB 211 5e-55 4AN9-A nrPDB 210 6e-55 5U6B-A nrPDB 210 8e-55 4K33-A nrPDB 210 9e-55 5MJB-A nrPDB 210 1e-54 4X7Q-B nrPDB 210 1e-54 2J0K-A nrPDB 210 1e-54 6O6Q-A nrPDB 210 1e-54 2DQ7-X nrPDB 210 1e-54 1JPA-A nrPDB 209 1e-54 2Y6O-A nrPDB 209 1e-54 3RAW-A nrPDB 209 2e-54 3DKO-A nrPDB 209 2e-54 3FME-A nrPDB 209 2e-54 1K9A-A nrPDB 209 2e-54 5UNP-A nrPDB 209 2e-54 6GVJ-A nrPDB 208 3e-54 4KIK-B nrPDB 207 5e-54 2VWV-A nrPDB 207 5e-54 2R2P-A nrPDB 207 5e-54 5AMN-A nrPDB 207 6e-54 3QUP-A nrPDB 207 6e-54 5L6P-A nrPDB 207 7e-54 1BYG-A nrPDB 207 1e-53 5TQX-A nrPDB 206 1e-53 4XUF-A nrPDB 206 1e-53 5X02-A nrPDB 206 1e-53 2WO6-A nrPDB 206 2e-53 2PL0-A nrPDB 206 2e-53 3HMP-A nrPDB 206 2e-53 3A4O-X nrPDB 206 2e-53 3QA8-A nrPDB 205 2e-53 2ZMD-A nrPDB 205 2e-53 4PDO-A nrPDB 205 3e-53 5AP3-A nrPDB 205 4e-53 2W1I-A nrPDB 204 4e-53 3IO7-A nrPDB 204 4e-53 3BGP-A nrPDB 204 5e-53 3ORP-A nrPDB 204 5e-53 2HK5-A nrPDB 204 6e-53 4LQP-A nrPDB 203 7e-53 2A1A-B nrPDB 203 9e-53 3QGY-A nrPDB 203 9e-53 1AD5-A nrPDB 203 1e-52 5FM2-A nrPDB 203 1e-52 3KUL-B nrPDB 203 1e-52 5TUR-A nrPDB 203 1e-52 3ZBF-A nrPDB 202 2e-52 4RC3-A nrPDB 202 2e-52 3DLS-A nrPDB 202 3e-52 1ZXE-A nrPDB 201 4e-52 5U6C-A nrPDB 201 5e-52 2BUJ-A nrPDB 201 5e-52 3SXS-A nrPDB 201 6e-52 5B2L-A nrPDB 200 7e-52 2RIO-A nrPDB 200 7e-52 4C59-A nrPDB 200 1e-51 6FEX-A nrPDB 199 1e-51 5IKW-A nrPDB 199 2e-51 3UIU-A nrPDB 199 2e-51 4Y83-A nrPDB 198 2e-51 6BSD-A nrPDB 198 4e-51 4HVI-A nrPDB 198 4e-51 5TE0-A nrPDB 198 4e-51 5KKR-C nrPDB 198 4e-51 5HI2-A nrPDB 198 5e-51 6DBN-A nrPDB 197 5e-51 6E4F-A nrPDB 197 8e-51 1U59-A nrPDB 197 8e-51 3EQC-A nrPDB 197 1e-50 4Y93-A nrPDB 195 2e-50 3I81-A nrPDB 195 3e-50 5HVK-A nrPDB 195 3e-50 4XI2-A nrPDB 194 5e-50 2PVN-A nrPDB 194 5e-50 5HIE-A nrPDB 194 7e-50 1LUF-A nrPDB 193 8e-50 6FER-A nrPDB 192 2e-49 5VD3-A nrPDB 192 2e-49 5HLW-A nrPDB 192 2e-49 3LZB-A nrPDB 192 2e-49 5GNK-A nrPDB 192 3e-49 3BBT-B nrPDB 192 3e-49 6HMD-A nrPDB 191 4e-49 4JLC-A nrPDB 191 4e-49 4FL3-A nrPDB 191 6e-49 3PLS-A nrPDB 190 7e-49 4EUU-A nrPDB 190 9e-49 3C1X-A nrPDB 190 1e-48 4EQM-A nrPDB 190 1e-48 1S9I-A nrPDB 190 1e-48 3AOX-A nrPDB 189 2e-48 4EUT-A nrPDB 189 2e-48 4MD7-E nrPDB 188 5e-48 4F0G-A nrPDB 188 5e-48 3OMV-A nrPDB 187 6e-48 4HZS-A nrPDB 187 8e-48 6EII-A nrPDB 187 9e-48 4TPT-A nrPDB 187 9e-48 6O8B-A nrPDB 187 1e-47 4IDT-A nrPDB 187 1e-47 6NT9-A nrPDB 186 2e-47 2JD5-A nrPDB 185 2e-47 4CRL-A nrPDB 185 2e-47 4LRM-A nrPDB 185 2e-47 1U54-B nrPDB 185 2e-47 3PP0-A nrPDB 183 1e-46 3HNG-A nrPDB 183 1e-46 4X3F-A nrPDB 182 2e-46 3LLT-A nrPDB 182 3e-46 5C26-A nrPDB 181 4e-46 4OW8-A nrPDB 181 6e-46 6B2Q-A nrPDB 181 6e-46 4M7I-A nrPDB 180 8e-46 5XVU-A nrPDB 179 2e-45 6DC0-A nrPDB 179 2e-45 5CEK-A nrPDB 179 2e-45 5WNO-A nrPDB 178 3e-45 4IAN-A nrPDB 177 5e-45 4NEU-A nrPDB 177 1e-44 4G3E-A nrPDB 175 2e-44 6CTH-A nrPDB 174 6e-44 4LFI-A nrPDB 172 2e-43 5UIU-A nrPDB 172 3e-43 3ZZW-A nrPDB 170 9e-43 2PMN-X nrPDB 168 3e-42 5LPZ-A nrPDB 166 2e-41 5LPV-A nrPDB 165 3e-41 5L2Q-C nrPDB 165 3e-41 5VDK-A nrPDB 165 4e-41 5TOS-A nrPDB 164 6e-41 2Y4I-B nrPDB 162 3e-40 6J5U-C nrPDB 161 5e-40 5VC6-A nrPDB 160 1e-39 3VHK-A nrPDB 157 6e-39 3UIM-A nrPDB 157 7e-39 3REP-A nrPDB 155 3e-38 2QKW-B nrPDB 153 9e-38 2H34-A nrPDB 153 2e-37 3QD2-B nrPDB 152 2e-37 4BTK-A nrPDB 150 9e-37 4NFN-A nrPDB 149 2e-36 4RT7-A nrPDB 149 2e-36 4M66-A nrPDB 149 2e-36 4F9B-A nrPDB 145 3e-35 4TN6-A nrPDB 142 2e-34 3SV0-A nrPDB 138 4e-33 2PZI-A nrPDB 137 8e-33 2CMW-A nrPDB 136 2e-32 5FQD-C nrPDB 135 5e-32 1CSN-A nrPDB 133 1e-31 2CHL-A nrPDB 133 1e-31 4Y12-A nrPDB 133 2e-31 2C47-A nrPDB 131 3e-31 4NT4-A nrPDB 131 3e-31 5M07-A nrPDB 130 2e-30 5X18-A nrPDB 129 3e-30 4XHH-A nrPDB 123 2e-28 4XHL-A nrPDB 120 1e-27 5OAT-A nrPDB 119 2e-27 6EQI-C nrPDB 106 2e-23 4IX6-A nrPDB 91 9e-19 Sequences not found previously or not previously below threshold: 4YFF-A nrPDB 173 8e-44 3LMG-A nrPDB 169 2e-42 5WNL-A nrPDB 164 5e-41 4WUA-A nrPDB 160 9e-40 2X7G-A nrPDB 158 3e-39 3Q4U-A nrPDB 154 7e-38 5AR8-A nrPDB 151 5e-37 2WTK-B nrPDB 150 8e-37 5XD6-A nrPDB 150 9e-37 3MDY-A nrPDB 150 1e-36 3MY0-A nrPDB 148 4e-36 1PY5-A nrPDB 145 3e-35 5E8V-A nrPDB 145 3e-35 3G2F-A nrPDB 143 1e-34 3SOC-A nrPDB 140 1e-33 6BFN-A nrPDB 130 1e-30 2QLU-A nrPDB 128 6e-30 4MWI-A nrPDB 124 8e-29 5J0A-A nrPDB 123 1e-28 5USZ-A nrPDB 123 2e-28 4BTF-A nrPDB 122 3e-28 4M69-B nrPDB 122 3e-28 4L00-A nrPDB 121 6e-28 5C01-A nrPDB 109 3e-24 4WOV-A nrPDB 108 3e-24 4JRN-A nrPDB 107 1e-23 5X1R-A nrPDB 103 2e-22 4I94-A nrPDB 102 3e-22 5UV4-A nrPDB 100 2e-21 5UU1-A nrPDB 96 2e-20 6J6I-B nrPDB 95 6e-20 5DMZ-A nrPDB 91 7e-19 4L68-A nrPDB 90 1e-18 2RSV-A nrPDB 87 9e-18 2LAV-A nrPDB 87 2e-17 6EWX-A nrPDB 84 1e-16 5CLR-A nrPDB 81 1e-15 6BHC-A nrPDB 79 3e-15 4CI6-B nrPDB 78 7e-15 4O1O-A nrPDB 76 3e-14 6G4J-A nrPDB 76 4e-14 5VE6-A nrPDB 75 4e-14 6EAS-A nrPDB 72 5e-13 4OAU-C nrPDB 71 6e-13 2JII-A nrPDB 70 2e-12 4CYJ-A nrPDB 61 1e-09 6M7Z-A nrPDB 56 3e-08 5GZA-A nrPDB 55 7e-08 4CZY-B nrPDB 53 2e-07 6R5K-O nrPDB 52 4e-07 4XR7-L nrPDB 51 7e-07 3Q60-A nrPDB 50 2e-06 3ENH-A nrPDB 49 5e-06 4AZV-A nrPDB 48 9e-06 4AZW-A nrPDB 48 9e-06 4WWA-A nrPDB 46 2e-05 4BWP-A nrPDB 46 3e-05 1TQM-A nrPDB 46 3e-05 3BYV-A nrPDB 45 8e-05 6G38-A nrPDB 42 4e-04 5GZ9-A nrPDB 41 6e-04 3J8B-F nrPDB 41 0.001 6G18-v nrPDB 41 0.001 2W1Z-A nrPDB 41 0.001 3DZO-A nrPDB 41 0.001 6FDN-A nrPDB 40 0.002 5A5T-F nrPDB 40 0.003 4BVU-A nrPDB 40 0.003 3ZO9-A nrPDB 38 0.009 4LXF-A nrPDB 37 0.018 6EF6-A nrPDB 36 0.035 >1NY3-A nrPDB Length = 400 Score = 602 bits (1552), Expect = e-172, Method: Composition-based stats. Identities = 400/400 (100%), Positives = 400/400 (100%) Query: 1 MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII 60 MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII Sbjct: 1 MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII 60 Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI 120 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI Sbjct: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI 120 Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI Sbjct: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY 240 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY Sbjct: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY 240 Query: 241 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 300 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM Sbjct: 241 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 300 Query: 301 LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL 360 LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL Sbjct: 301 LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL 360 Query: 361 ATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH 400 ATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH Sbjct: 361 ATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH 400 >2OZA-A nrPDB Length = 356 Score = 529 bits (1362), Expect = e-150, Method: Composition-based stats. Identities = 354/354 (100%), Positives = 354/354 (100%) Query: 47 HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE 106 HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE Sbjct: 3 HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE 62 Query: 107 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI Sbjct: 63 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 122 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 226 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT Sbjct: 123 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 182 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF Sbjct: 183 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 242 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDK 346 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDK Sbjct: 243 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDK 302 Query: 347 ERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH 400 ERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH Sbjct: 303 ERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH 356 >3KA0-A nrPDB Length = 320 Score = 477 bits (1227), Expect = e-135, Method: Composition-based stats. Identities = 319/320 (99%), Positives = 319/320 (99%) Query: 47 HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE 106 HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE Sbjct: 1 HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE 60 Query: 107 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI Sbjct: 61 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 120 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 226 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT PCYT Sbjct: 121 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYT 180 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF Sbjct: 181 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 240 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDK 346 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDK Sbjct: 241 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDK 300 Query: 347 ERWEDVKEEMTSALATMRVD 366 ERWEDVKEEMTSALATMRVD Sbjct: 301 ERWEDVKEEMTSALATMRVD 320 >3FXW-A nrPDB Length = 336 Score = 430 bits (1106), Expect = e-121, Method: Composition-based stats. Identities = 243/320 (75%), Positives = 286/320 (89%), Gaps = 1/320 (0%) Query: 51 GLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWR 110 G + KK A+ DDY+++ QVLGLG+NGKVL+ F++RT +K ALK+L D PKAR+EV+ HW+ Sbjct: 18 GPEPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQ 77 Query: 111 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 AS PHIV I+DVYEN++ G++CLLI+MEC++GGELFSRIQ+RGDQAFTEREA+EIM+ I Sbjct: 78 ASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDI 137 Query: 171 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYV 230 G AIQ+LHS NIAHRDVKPENLLYTSK +A+LKLTDFGFAKETT N+L TPCYTPYYV Sbjct: 138 GTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETT-QNALQTPCYTPYYV 196 Query: 231 APEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE 290 APEVLGPEKYDKSCDMWSLGVIMYILLCG+PPFYSN G AISPGMK RIR+GQY FPNPE Sbjct: 197 APEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPE 256 Query: 291 WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE 350 WSEVSE+ K LIR LLKT+PT+R+TIT+FMNHPWI QS VPQTPLHT+RVL+EDK+ W+ Sbjct: 257 WSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKDHWD 316 Query: 351 DVKEEMTSALATMRVDYEQI 370 +VKEEMTSALATMRVDY+Q+ Sbjct: 317 EVKEEMTSALATMRVDYDQV 336 >3M42-A nrPDB Length = 299 Score = 430 bits (1106), Expect = e-121, Method: Composition-based stats. Identities = 296/318 (93%), Positives = 296/318 (93%), Gaps = 21/318 (6%) Query: 47 HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE 106 HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE Sbjct: 3 HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE 62 Query: 107 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI Sbjct: 63 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 122 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 226 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT Sbjct: 123 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT----------- 171 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286 EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF Sbjct: 172 ----------GEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 221 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDK 346 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDK Sbjct: 222 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDK 281 Query: 347 ERWEDVKEEMTSALATMR 364 ERWEDVKEEMTSALATMR Sbjct: 282 ERWEDVKEEMTSALATMR 299 >5JN2-A nrPDB Length = 525 Score = 371 bits (954), Expect = e-103, Method: Composition-based stats. Identities = 115/401 (28%), Positives = 178/401 (44%), Gaps = 37/401 (9%) Query: 8 QSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTS 67 Q + A P + P P F Q AI D Sbjct: 22 QESTLGGAAGEPRSRGHAAGTSGGPGDHLHATPGMFVQ---------HSTAIFSDRYKGQ 72 Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQ--------DCPKARREVELHWRASQCPHIVR 119 +VLG G G+V+ +K T ++ A+K++ D REV+L + P+I++ Sbjct: 73 RVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQL-LKQLDHPNIMK 131 Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 + + +E+ + +V E GGELF I R + F+E +A+ I++ + I Y+H Sbjct: 132 LYEFFED----KGYFYLVGEVYTGGELFDEIISR--KRFSEVDAARIIRQVLSGITYMHK 185 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEK 239 I HRD+KPENLL SK +A +++ DFG + + + T YY+APEVL Sbjct: 186 NKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGT- 244 Query: 240 YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVK 299 YD+ CD+WS GVI+YILL G PPF + I ++ G+Y F P+W +VSE K Sbjct: 245 YDEKCDVWSTGVILYILLSGCPPFNGANEYDI----LKKVEKGKYTFELPQWKKVSESAK 300 Query: 300 MLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVP--------QTPLHTSRVLKEDKERWED 351 LIR +L P+ R++ + ++H WI TK + R + ++ + Sbjct: 301 DLIRKMLTYVPSMRISARDALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQA 360 Query: 352 VKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARA 392 M S L + E I D + L R + Sbjct: 361 ALLYMGSKLTSQDETKELTAIFHKMDKNGDGQLDRAELIEG 401 >3NCG-A nrPDB Length = 486 Score = 361 bits (926), Expect = e-100, Method: Composition-based stats. Identities = 113/353 (32%), Positives = 183/353 (51%), Gaps = 29/353 (8%) Query: 56 KNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELH 108 + + Y + +LG G G+VL+ ++ TQ+++A+K++ +D REVEL Sbjct: 17 QGTFAERYNIVC-MLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELL 75 Query: 109 WRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMK 168 + P+I+++ ++ E+ IV E GGELF I R + F+E +A+ I+K Sbjct: 76 KKL-DHPNIMKLFEILEDS----SSFYIVGELYTGGELFDEIIKR--KRFSEHDAARIIK 128 Query: 169 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY 228 + I Y+H NI HRD+KPEN+L SK + +K+ DFG + + + T Y Sbjct: 129 QVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAY 188 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN 288 Y+APEVL YD+ CD+WS GVI+YILL G PPFY + I R+ G+Y F Sbjct: 189 YIAPEVLRGT-YDEKCDVWSAGVILYILLSGTPPFYGKNEYDI----LKRVETGKYAFDL 243 Query: 289 PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKV---------PQTPLHTS 339 P+W +S++ K LIR +L P+ R+T T+ + HPWI + + ++ + Sbjct: 244 PQWRTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYSSETPTISDLPSLESAMTNI 303 Query: 340 RVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARA 392 R + +K+ + M S L T+ + +I + D +N +L R + R Sbjct: 304 RQFQAEKKLAQAALLYMASKLTTLDETKQLTEIFRKLDTNNDGMLDRDELVRG 356 >3HZT-A nrPDB Length = 467 Score = 344 bits (884), Expect = 3e-95, Method: Composition-based stats. Identities = 114/351 (32%), Positives = 181/351 (51%), Gaps = 30/351 (8%) Query: 59 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK--------ARREVELHWR 110 + D Y+ + LG G G+VL +K T + A+K+++ EV + + Sbjct: 2 LSDRYQRVKK-LGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAV-LK 59 Query: 111 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 P+I+++ + +E+ ++ +VME GGELF I R Q F+E +A+ IMK + Sbjct: 60 QLDHPNIMKLYEFFED----KRNYYLVMEVYRGGELFDEIILR--QKFSEVDAAVIMKQV 113 Query: 171 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYV 230 YLH NI HRD+KPENLL SK +A++K+ DFG + + T YY+ Sbjct: 114 LSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYI 173 Query: 231 APEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE 290 APEVL +KYD+ CD+WS GVI+YILLCGYPPF + R+ G++ F P+ Sbjct: 174 APEVL-RKKYDEKCDVWSCGVILYILLCGYPPFGG----QTDQEILKRVEKGKFSFDPPD 228 Query: 291 WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQT---------PLHTSRV 341 W++VS+E K L++ +L EP++R++ E +NHPWI++ T L + Sbjct: 229 WTQVSDEAKQLVKLMLTYEPSKRISAEEALNHPWIVKFCSQKHTDVGKHALTGALGNMKK 288 Query: 342 LKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARA 392 + ++ + M S L T+ E +I + D + L R++ Sbjct: 289 FQSSQKLAQAAMLFMGSKLTTLEETKELTQIFRQLDNNGDGQLDRKELIEG 339 >4MVF-A nrPDB Length = 506 Score = 339 bits (871), Expect = 1e-93, Method: Composition-based stats. Identities = 125/355 (35%), Positives = 196/355 (55%), Gaps = 22/355 (6%) Query: 50 SGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALK-----MLQDCPKARRE 104 L + + ++D + + LG G G V + +K T + +A+K L++ + +E Sbjct: 45 KNLILCHSGKLEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQE 104 Query: 105 VELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREAS 164 +E+ + P+IV++ + YEN + ++ME G ELF I + G +FTE+ A+ Sbjct: 105 IEIMKKL-DHPNIVKLYETYEN----DNYIYLIMELCSGRELFDSIIENG--SFTEKNAA 157 Query: 165 EIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPC 224 IMK I AI YLHS+NI HRD+KPEN L+ S+ +++LK+ DFG +K + TT Sbjct: 158 TIMKQIFSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKA 217 Query: 225 YTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQY 284 TPYYVAP+VL + YDK CD+WS GVIMY LLCGYPPFY + + +++ G++ Sbjct: 218 GTPYYVAPQVLDGK-YDKKCDIWSSGVIMYTLLCGYPPFYGD----TDNEVLKKVKKGEF 272 Query: 285 EFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLK- 343 F +W +S + K LI LL P +R TI E +NHPWI Q TK + +S +LK Sbjct: 273 CFYENDWGSISSDAKNLITKLLTYNPNERCTIEEALNHPWITQMTKSHEHVELSSTLLKN 332 Query: 344 -EDKERWEDVKEEMTSALATMRVDYEQIKIKKI---EDASNPLLLKRRKKARALE 394 ++ ++ ++K+ + +A D E ++ I D N L ++ L+ Sbjct: 333 LKNFKKENELKKIALTIIAKHLCDVEINNLRNIFIALDVDNSGTLSSQEILDGLK 387 >3LIJ-A nrPDB Length = 494 Score = 338 bits (866), Expect = 3e-93, Method: Composition-based stats. Identities = 110/354 (31%), Positives = 178/354 (50%), Gaps = 29/354 (8%) Query: 55 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP-------KARREVEL 107 KK + + Y+ + LG G G+VL +K T + A+K+++ K EV + Sbjct: 31 KKGHLSEMYQRVKK-LGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAV 89 Query: 108 HWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIM 167 + P+I+++ D +E+ ++ +VMEC GGELF I R F E +A+ I+ Sbjct: 90 -LKLLDHPNIMKLYDFFED----KRNYYLVMECYKGGELFDEIIHRM--KFNEVDAAVII 142 Query: 168 KSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTP 227 K + + YLH NI HRD+KPENLL SK +A++K+ DFG + + + T Sbjct: 143 KQVLSGVTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTA 202 Query: 228 YYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 YY+APEVL +KYD+ CD+WS+GVI++ILL GYPPF + ++ G+Y F Sbjct: 203 YYIAPEVL-RKKYDEKCDVWSIGVILFILLAGYPPFGG----QTDQEILRKVEKGKYTFD 257 Query: 288 NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ---------TPLHT 338 +PEW VSE K LI+ +L+ + +R++ + + HPWI + + + Sbjct: 258 SPEWKNVSEGAKDLIKQMLQFDSQRRISAQQALEHPWIKEMCSKKESGIELPSLANAIEN 317 Query: 339 SRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARA 392 R + ++ + M S L + E I + D + L R++ Sbjct: 318 MRKFQNSQKLAQAALLYMASKLTSQEETKELTDIFRHIDKNGDGQLDRQELIDG 371 >4YZB-A nrPDB Length = 491 Score = 336 bits (862), Expect = 1e-92, Method: Composition-based stats. Identities = 109/375 (29%), Positives = 182/375 (48%), Gaps = 29/375 (7%) Query: 35 PPPPPPQQFPQFHVKSGLQIKKN--AIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFAL 92 P P + + G+ ++ + A D YK +VLG G G+V+ +K T +++A+ Sbjct: 2 PGSPAASKSDKLAATPGMFVQHSTAAFSDRYK-GQRVLGKGSFGEVILCKDKVTGQEYAV 60 Query: 93 KMLQDCPKARR-------EVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGE 145 K++ ++ + + P+I+++ + +E+ + +V E GGE Sbjct: 61 KVISKRQVKQKTDKELLLKEVELLKKLDHPNIMKLYEFFED----KGYFYLVTEVYTGGE 116 Query: 146 LFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKL 205 LF I R + F+E +A+ I++ + I Y+H I HRD+KPENLL +KR +A +++ Sbjct: 117 LFDEIISR--KRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRI 174 Query: 206 TDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYS 265 DFG + S + T YY+APEVL YD+ CD+WS GVI+YILL G PPF Sbjct: 175 IDFGLSTHFESTKKMKDKIGTAYYIAPEVLHGT-YDEKCDVWSTGVILYILLSGCPPFNG 233 Query: 266 NHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 + I ++ G++ F P+W +VSE K LIR +L PT R++ + + H W+ Sbjct: 234 ANEFDI----LKKVEKGKFTFDLPQWKKVSEPAKDLIRKMLAYVPTMRISARDALEHEWL 289 Query: 326 M------QSTKVP--QTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIED 377 S VP ++ + R + ++ M S L T E KI + D Sbjct: 290 KTTDAATDSIDVPSLESTILNIRQFQGTQKLAAAALLYMGSKLTTNEETVELNKIFQRMD 349 Query: 378 ASNPLLLKRRKKARA 392 + L +++ Sbjct: 350 KNGDGQLDKQELMEG 364 >5U6Y-A nrPDB Length = 461 Score = 331 bits (848), Expect = 4e-91, Method: Composition-based stats. Identities = 109/349 (31%), Positives = 171/349 (48%), Gaps = 29/349 (8%) Query: 63 YKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQCP 115 Y++ + LG G V + +++A K++ +D K RE + R + P Sbjct: 2 YQLFEE-LGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARI-CRLLKHP 59 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 +IVR+ D + ++ + + GGELF I R + ++E +AS ++ I EA+ Sbjct: 60 NIVRLHDSI----SEEGHHYLIFDLVTGGELFEDIVAR--EYYSEADASHCIQQILEAVL 113 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT-SHNSLTTPCYTPYYVAPEV 234 + H + + HRD+KPENLL SK A +KL DFG A E + TP Y++PEV Sbjct: 114 HCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEV 173 Query: 235 LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 294 L + Y K D+W+ GVI+YILL GYPPF+ + +I+ G Y+FP+PEW V Sbjct: 174 LRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQ----HRLYQQIKAGAYDFPSPEWDTV 229 Query: 295 SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ--TPLHTSRVLKEDKERWEDV 352 + E K LI +L P++R+T E + HPWI + V T LK+ R + Sbjct: 230 TPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLK 289 Query: 353 KEEMTSALATMRVD-------YEQIKIKKIEDASNPLLLKRRKKARALE 394 +T+ LAT + +K+ +++N + K R E Sbjct: 290 GAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQE 338 >3SOA-A nrPDB Length = 444 Score = 330 bits (846), Expect = 8e-91, Method: Composition-based stats. Identities = 106/329 (32%), Positives = 165/329 (50%), Gaps = 22/329 (6%) Query: 59 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFAL-----KML--QDCPKARREVELHWRA 111 ++Y++ + LG G V + +++A K L +D K RE + R Sbjct: 9 FTEEYQLFEE-LGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARI-CRL 66 Query: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 + P+IVR+ D + ++ + + GGELF I R + ++E +AS ++ I Sbjct: 67 LKHPNIVRLHDSI----SEEGHHYLIFDLVTGGELFEDIVAR--EYYSEADASHCIQQIL 120 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT-SHNSLTTPCYTPYYV 230 EA+ + H + + HR++KPENLL SK A +KL DFG A E + TP Y+ Sbjct: 121 EAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYL 180 Query: 231 APEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE 290 +PEVL + Y K D+W+ GVI+YILL GYPPF+ + +I+ G Y+FP+PE Sbjct: 181 SPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQ----HRLYQQIKAGAYDFPSPE 236 Query: 291 WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ--TPLHTSRVLKEDKER 348 W V+ E K LI +L P++R+T E + HPWI + V T LK+ R Sbjct: 237 WDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNAR 296 Query: 349 WEDVKEEMTSALATMRVDYEQIKIKKIED 377 + +T LAT + +I K+ + Sbjct: 297 RKLKGAILTVMLATRNFSVRKQEIIKVTE 325 >2BDW-A nrPDB Length = 362 Score = 330 bits (846), Expect = 8e-91, Method: Composition-based stats. Identities = 111/336 (33%), Positives = 168/336 (50%), Gaps = 21/336 (6%) Query: 59 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRA 111 D+Y V + LG G V + +K T +FA K++ +D K RE + R Sbjct: 27 FSDNYDVKEE-LGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARI-CRK 84 Query: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 Q P+IVR+ D + +V + + GGELF I R + ++E +AS ++ I Sbjct: 85 LQHPNIVRLHDSIQE----ESFHYLVFDLVTGGELFEDIVAR--EFYSEADASHCIQQIL 138 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVA 231 E+I Y HS I HR++KPENLL SK A +KL DFG A E + TP Y++ Sbjct: 139 ESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLS 198 Query: 232 PEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW 291 PEVL + Y K D+W+ GVI+YILL GYPPF+ + +I+ G Y++P+PEW Sbjct: 199 PEVLKKDPYSKPVDIWACGVILYILLVGYPPFWDEDQ----HRLYAQIKAGAYDYPSPEW 254 Query: 292 SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ--TPLHTSRVLKEDKERW 349 V+ E K LI ++L P +R+T + + PWI +V T LK+ R Sbjct: 255 DTVTPEAKSLIDSMLTVNPKKRITADQALKVPWICNRERVASAIHRQDTVDCLKKFNARR 314 Query: 350 EDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLK 385 + +T+ +AT + + ++ P +K Sbjct: 315 KLKGAILTTMIATRNLSNLGRNLLNKKEQGPPSTIK 350 >2VN9-A nrPDB Length = 301 Score = 326 bits (836), Expect = 1e-89, Method: Composition-based stats. Identities = 107/313 (34%), Positives = 162/313 (51%), Gaps = 22/313 (7%) Query: 58 AIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWR 110 ++ D+Y++ + LG G V + T +++A K++ +D K RE + R Sbjct: 1 SMTDEYQLFEE-LGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARI-CR 58 Query: 111 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 + P+IVR+ D + +V + + GGELF I R + ++E +AS ++ I Sbjct: 59 LLKHPNIVRLHDSI----SEEGFHYLVFDLVTGGELFEDIVAR--EYYSEADASHCIQQI 112 Query: 171 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET-TSHNSLTTPCYTPYY 229 E++ + H I HRD+KPENLL SK A +KL DFG A E + TP Y Sbjct: 113 LESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY 172 Query: 230 VAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNP 289 ++PEVL + Y K DMW+ GVI+YILL GYPPF+ + +I+ G Y+FP+P Sbjct: 173 LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQ----HRLYQQIKAGAYDFPSP 228 Query: 290 EWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQT--PLHTSRVLKEDKE 347 EW V+ E K LI +L P +R+T +E + HPWI Q + V T LK+ Sbjct: 229 EWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNA 288 Query: 348 RWEDVKEEMTSAL 360 R + +T+ L Sbjct: 289 RRKLKGAILTTML 301 >2V7O-A nrPDB Length = 336 Score = 323 bits (828), Expect = 8e-89, Method: Composition-based stats. Identities = 104/319 (32%), Positives = 161/319 (50%), Gaps = 22/319 (6%) Query: 59 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRA 111 DDY++ + LG G V + K +++A K++ +D K RE + R Sbjct: 29 FTDDYQLFEE-LGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARI-CRL 86 Query: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 + P+IVR+ D + +V + + GGELF I R + ++E +AS + I Sbjct: 87 LKHPNIVRLHDSI----SEEGFHYLVFDLVTGGELFEDIVAR--EYYSEADASHCIHQIL 140 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET-TSHNSLTTPCYTPYYV 230 E++ ++H +I HRD+KPENLL SK A +KL DFG A E + TP Y+ Sbjct: 141 ESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYL 200 Query: 231 APEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE 290 +PEVL + Y K D+W+ GVI+YILL GYPPF+ + +I+ G Y+FP+PE Sbjct: 201 SPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQ----HKLYQQIKAGAYDFPSPE 256 Query: 291 WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQT--PLHTSRVLKEDKER 348 W V+ E K LI +L P +R+T + + HPW+ Q + V T L++ R Sbjct: 257 WDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNAR 316 Query: 349 WEDVKEEMTSALATMRVDY 367 + +T+ L + Sbjct: 317 RKLKGAILTTMLVSRNFSV 335 >4RGJ-A nrPDB Length = 520 Score = 322 bits (825), Expect = 2e-88, Method: Composition-based stats. Identities = 104/371 (28%), Positives = 177/371 (47%), Gaps = 31/371 (8%) Query: 41 QQFPQFHVKSGLQIKK-NAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ--- 96 F ++ G+ I+ N + ++ ++LG G G+V+ +K T ++A+K++ Sbjct: 38 NSFNNSKLRPGMFIQNSNVVFNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKH 97 Query: 97 -----DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQ 151 D REVEL + +I+++ + +E+ +V + GGELF I Sbjct: 98 VKRKTDKESLLREVEL-LKMLDHINIMKLYEFFED----NNYYYLVSDVYTGGELFDEII 152 Query: 152 DRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSK-RPNAILKLTDFGF 210 R + F E +A+ I+K I I Y+H N+ HRD+KPEN+L +K + + I+K+ DFG Sbjct: 153 SR--KRFYEIDAARIIKQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGL 210 Query: 211 AKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLA 270 + + T YY+AP+VL YD+ CD+WS GVI+YILL G PPF ++ Sbjct: 211 STHFEYSKKMKDKIGTAYYIAPDVLHGT-YDEKCDIWSCGVILYILLSGCPPFNGSNEYD 269 Query: 271 ISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTK 330 I ++ G+Y F P++ ++S++ K LI+ +L R++ + + H WI T Sbjct: 270 I----LKKVEAGKYTFDLPQFKKISDKAKDLIKKMLMYTSAVRISARDALEHEWIKMMTS 325 Query: 331 V---------PQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNP 381 + + R + ++ + M S L T+ E KI K D + Sbjct: 326 KDNLNIDIPSLELSIANIRQFQSTQKLAQAALLYMGSKLTTIDETKELTKIFKKMDKNGD 385 Query: 382 LLLKRRKKARA 392 L R + Sbjct: 386 GQLDRNELIIG 396 >5FG8-A nrPDB Length = 285 Score = 320 bits (821), Expect = 5e-88, Method: Composition-based stats. Identities = 103/284 (36%), Positives = 150/284 (52%), Gaps = 20/284 (7%) Query: 59 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRA 111 D+Y + + LG G V + K T +FA K++ +D K RE + R Sbjct: 12 FSDNYDIKEE-LGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARI-CRK 69 Query: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 P+IVR+ D + +V + + GGELF I R + ++E +AS ++ I Sbjct: 70 LHHPNIVRLHDSIQE----ENYHYLVFDLVTGGELFEDIVAR--EFYSEADASHCIQQIL 123 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET-TSHNSLTTPCYTPYYV 230 E++ + H + HRD+KPENLL SK A +KL DFG A E H + TP Y+ Sbjct: 124 ESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYL 183 Query: 231 APEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE 290 +PEVL E Y KS D+W+ GVI+YILL GYPPF+ + ++I+ G Y++P+PE Sbjct: 184 SPEVLKKEPYGKSVDIWACGVILYILLVGYPPFWDEDQ----HRLYSQIKAGAYDYPSPE 239 Query: 291 WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQT 334 W V+ E K LI +L P +R+T E + HPWI Q +V Sbjct: 240 WDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWICQRERVASV 283 >4NIF-A nrPDB Length = 333 Score = 319 bits (817), Expect = 2e-87, Method: Composition-based stats. Identities = 117/347 (33%), Positives = 191/347 (55%), Gaps = 23/347 (6%) Query: 55 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKA-RREVELHWRASQ 113 N + D V + +G+G + + +K T ++A+K++ + E+E+ R Q Sbjct: 1 GSNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQ 60 Query: 114 CPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEA 173 P+I+ + DVY++ K + +V E + GGEL +I + + F+EREAS ++ +IG+ Sbjct: 61 HPNIITLKDVYDD----GKHVYLVTELMRGGELLDKILRQ--KFFSEREASFVLHTIGKT 114 Query: 174 IQYLHSINIAHRDVKPENLLYTSKRPNAI-LKLTDFGFAKETTSHNSL-TTPCYTPYYVA 231 ++YLHS + HRD+KP N+LY + N L++ DFGFAK+ + N L TPCYT +VA Sbjct: 115 VEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVA 174 Query: 232 PEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW 291 PEVL + YD+ CD+WSLG+++Y +L GY PF +N + TRI G++ W Sbjct: 175 PEVLKRQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGSGKFTLSGGNW 233 Query: 292 SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWED 351 + VSE K L+ +L +P QR+T + + HPW+ Q K+PQ+ L + + Sbjct: 234 NTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDL--------QL 285 Query: 352 VKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAAL 398 VK M + + + ++K IE + +L +RR R L + L Sbjct: 286 VKGAMAATYSALNSSKPTPQLKPIESS---ILAQRR--VRKLPSTTL 327 >2W4O-A nrPDB Length = 349 Score = 318 bits (816), Expect = 2e-87, Method: Composition-based stats. Identities = 117/342 (34%), Positives = 183/342 (53%), Gaps = 18/342 (5%) Query: 27 ALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRT 86 ++ A P P + + ++A+ D ++V S+ LG G V + K T Sbjct: 22 SMSSVTASAAPGTASLVPDYWIDGS---NRDALSDFFEVESE-LGRGATSIVYRCKQKGT 77 Query: 87 QEKFALKMLQ---DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDG 143 Q+ +ALK+L+ D R E+ + R S P+I+++ +++E + +V+E + G Sbjct: 78 QKPYALKVLKKTVDKKIVRTEIGVLLRLS-HPNIIKLKEIFETPTE----ISLVLELVTG 132 Query: 144 GELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAIL 203 GELF RI ++G ++ER+A++ +K I EA+ YLH I HRD+KPENLLY + P+A L Sbjct: 133 GELFDRIVEKG--YYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPL 190 Query: 204 KLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPF 263 K+ DFG +K + T C TP Y APE+L Y DMWS+G+I YILLCG+ PF Sbjct: 191 KIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPF 250 Query: 264 YSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHP 323 Y G M RI +Y F +P W EVS K L+R L+ +P +R+T + + HP Sbjct: 251 YDERG---DQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHP 307 Query: 324 WIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRV 365 W+ + L+E R + +K + + +A+ R+ Sbjct: 308 WVTGKAANFVHMDTAQKKLQEFNARRK-LKAAVKAVVASSRL 348 >3DFA-A nrPDB Length = 286 Score = 318 bits (816), Expect = 3e-87, Method: Composition-based stats. Identities = 101/283 (35%), Positives = 157/283 (55%), Gaps = 20/283 (7%) Query: 56 KNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELH 108 + + Y + +LG G G+VL+ ++ TQ+++A+K++ +D REVEL Sbjct: 17 QGTFAERYNIVC-MLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELL 75 Query: 109 WRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMK 168 + P+I+++ ++ E+ IV E GGELF I R + F+E +A+ I+K Sbjct: 76 KKL-DHPNIMKLFEILEDS----SSFYIVGELYTGGELFDEIIKR--KRFSEHDAARIIK 128 Query: 169 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY 228 + I Y+H NI HRD+KPEN+L SK + +K+ DFG + + + T Y Sbjct: 129 QVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAY 188 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN 288 Y+APEVL YD+ CD+WS GVI+YILL G PPFY + I R+ G+Y F Sbjct: 189 YIAPEVLRGT-YDEKCDVWSAGVILYILLSGTPPFYGKNEYDI----LKRVETGKYAFDL 243 Query: 289 PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKV 331 P+W +S++ K LIR +L P+ R+T T+ + HPWI + + Sbjct: 244 PQWRTISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYSSE 286 >3MA6-A nrPDB Length = 298 Score = 318 bits (814), Expect = 4e-87, Method: Composition-based stats. Identities = 99/285 (34%), Positives = 152/285 (53%), Gaps = 20/285 (7%) Query: 55 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ--------DCPKARREVE 106 AI D +VLG G G+V+ +K T ++ A+K++ D REV+ Sbjct: 25 HSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQ 84 Query: 107 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 L + P+I+++ + +E+ + +V E GGELF I R + F+E +A+ I Sbjct: 85 L-LKQLDHPNIMKLYEFFED----KGYFYLVGEVYTGGELFDEIISR--KRFSEVDAARI 137 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 226 ++ + I Y+H I HRD+KPENLL SK +A +++ DFG + + + T Sbjct: 138 IRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGT 197 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286 YY+APEVL YD+ CD+WS GVI+YILL G PPF + I ++ G+Y F Sbjct: 198 AYYIAPEVLHGT-YDEKCDVWSTGVILYILLSGCPPFNGANEYDI----LKKVEKGKYTF 252 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKV 331 P+W +VSE K LIR +L P+ R++ + ++H WI TK Sbjct: 253 ELPQWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKE 297 >3DXN-A nrPDB Length = 287 Score = 318 bits (814), Expect = 4e-87, Method: Composition-based stats. Identities = 103/279 (36%), Positives = 159/279 (56%), Gaps = 21/279 (7%) Query: 57 NAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK--------ARREVELH 108 + D Y+ + LG G G+VL +K T + A+K+++ EV + Sbjct: 17 QGLSDRYQRVKK-LGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAV- 74 Query: 109 WRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMK 168 + P+I+++ + +E+ ++ +VME GGELF I R Q F+E +A+ IMK Sbjct: 75 LKQLDHPNIMKLYEFFED----KRNYYLVMEVYRGGELFDEIILR--QKFSEVDAAVIMK 128 Query: 169 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY 228 + YLH NI HRD+KPENLL SK +A++K+ DFG + + T Y Sbjct: 129 QVLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAY 188 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN 288 Y+APEVL +KYD+ CD+WS GVI+YILLCGYPPF + R+ G++ F Sbjct: 189 YIAPEVL-RKKYDEKCDVWSCGVILYILLCGYPPFGG----QTDQEILKRVEKGKFSFDP 243 Query: 289 PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 P+W++VS+E K L++ +L EP++R++ E +NHPWI++ Sbjct: 244 PDWTQVSDEAKQLVKLMLTYEPSKRISAEEALNHPWIVK 282 >5IG1-A nrPDB Length = 344 Score = 317 bits (813), Expect = 5e-87, Method: Composition-based stats. Identities = 107/300 (35%), Positives = 155/300 (51%), Gaps = 19/300 (6%) Query: 62 DYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQC 114 D K V+G G V + NKRT E A+K++ + K +RE+ + + Q Sbjct: 17 DLKDKRSVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGI-CSSLQH 75 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 HIV + + + +V E + GGELF I R + + E++AS M I A+ Sbjct: 76 EHIVSMRRAFRD----ESHFYLVFEYVSGGELFDEIVTR--KFYNEKDASACMHQILSAL 129 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV 234 Q+ HS NI HRD+KPENLL SK PNA +K+TDFG A + TP Y++PEV Sbjct: 130 QHCHSKNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEV 189 Query: 235 LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 294 + YD + D+W+ GVI+YILL GYPPF+ + +I+ QY+FP+PEW V Sbjct: 190 IRRVPYDTAVDVWACGVILYILLVGYPPFWEED----HQKLYAQIKNCQYDFPSPEWDSV 245 Query: 295 SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIM-QSTKVPQTPLHTSRVLKEDKERWEDVK 353 + K LI+ +L+ P +R T+ E + HPWI + T LK+ R + Sbjct: 246 TTAAKELIKAMLEPNPKRRPTVQELLQHPWIARRDVPGSVHRQATLEELKKFNARRKLKG 305 >3Q5I-A nrPDB Length = 504 Score = 314 bits (805), Expect = 4e-86, Method: Composition-based stats. Identities = 112/368 (30%), Positives = 175/368 (47%), Gaps = 39/368 (10%) Query: 51 GLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC------------ 98 ++ K+ I + Y + LG G G+VL K + A+K+++ Sbjct: 26 YVRKKEGKIGESYFKVRK-LGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNK 84 Query: 99 ------PKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQD 152 + E+ L ++ P+I+++ DV+E+ +K +V E +GGELF +I + Sbjct: 85 NIEKFHEEIYNEISL-LKSLDHPNIIKLFDVFED----KKYFYLVTEFYEGGELFEQIIN 139 Query: 153 RGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK 212 R F E +A+ IMK I I YLH NI HRD+KPEN+L +K +K+ DFG + Sbjct: 140 R--HKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSS 197 Query: 213 ETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAIS 272 + L T YY+APEVL +KY++ CD+WS GVIMYILLCGYPPF + I Sbjct: 198 FFSKDYKLRDRLGTAYYIAPEVL-KKKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDII 256 Query: 273 PGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ----- 327 ++ G+Y F +W +S+E K LI+ +L + +R T E +N WI + Sbjct: 257 ----KKVEKGKYYFDFNDWKNISDEAKELIKLMLTYDYNKRCTAEEALNSRWIKKYANNI 312 Query: 328 ---STKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLL 384 K L R + ++ + + S L T+ E I K D + L Sbjct: 313 NKSDQKTLCGALSNMRKFEGSQKLAQAAILFIGSKLTTLEERKELTDIFKKLDKNGDGQL 372 Query: 385 KRRKKARA 392 +++ Sbjct: 373 DKKELIEG 380 >2VZ6-A nrPDB Length = 313 Score = 314 bits (805), Expect = 4e-86, Method: Composition-based stats. Identities = 100/301 (33%), Positives = 153/301 (50%), Gaps = 22/301 (7%) Query: 63 YKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQCP 115 Y++ + LG G V + +++A K++ +D K RE + R + P Sbjct: 24 YQLFEE-LGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARI-CRLLKHP 81 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 +IVR+ D + ++ + + GGELF I R + ++E +AS ++ I EA+ Sbjct: 82 NIVRLHDSI----SEEGHHYLIFDLVTGGELFEDIVAR--EYYSEADASHCIQQILEAVL 135 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT-SHNSLTTPCYTPYYVAPEV 234 + H + + HRD+KPENLL SK A +KL DFG A E + TP Y++PEV Sbjct: 136 HCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEV 195 Query: 235 LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 294 L + Y K D+W+ GVI+YILL GYPPF+ + +I+ G Y+FP+PEW V Sbjct: 196 LRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQ----HRLYQQIKAGAYDFPSPEWDTV 251 Query: 295 SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ--TPLHTSRVLKEDKERWEDV 352 + E K LI +L P++R+T E + HPWI + V T LK+ R + Sbjct: 252 TPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLK 311 Query: 353 K 353 Sbjct: 312 G 312 >3BHH-A nrPDB Length = 295 Score = 314 bits (805), Expect = 5e-86, Method: Composition-based stats. Identities = 102/306 (33%), Positives = 155/306 (50%), Gaps = 22/306 (7%) Query: 58 AIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWR 110 ++ D+Y++ +G G V + T ++A K++ +D K RE + R Sbjct: 1 SMTDEYQLYED-IGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARI-CR 58 Query: 111 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 + +IVR+ D + +V + + GGELF I R + ++E +AS ++ I Sbjct: 59 LLKHSNIVRLHDSI----SEEGFHYLVFDLVTGGELFEDIVAR--EYYSEADASHCIQQI 112 Query: 171 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET-TSHNSLTTPCYTPYY 229 EA+ + H + + HRD+KPENLL SK A +KL DFG A E + TP Y Sbjct: 113 LEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY 172 Query: 230 VAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNP 289 ++PEVL E Y K D+W+ GVI+YILL GYPPF+ + +I+ G Y+FP+P Sbjct: 173 LSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQ----HKLYQQIKAGAYDFPSP 228 Query: 290 EWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQT--PLHTSRVLKEDKE 347 EW V+ E K LI +L P +R+T E + HPW+ Q + V T LK+ Sbjct: 229 EWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNA 288 Query: 348 RWEDVK 353 R + Sbjct: 289 RRKLKG 294 >3KK8-A nrPDB Length = 284 Score = 312 bits (800), Expect = 2e-85, Method: Composition-based stats. Identities = 104/293 (35%), Positives = 151/293 (51%), Gaps = 21/293 (7%) Query: 59 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRA 111 D+Y V + LG G V + +K T +FA K++ +D K RE + R Sbjct: 4 FSDNYDVKEE-LGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARI-CRK 61 Query: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 Q P+IVR+ D + +V + + GGELF I R + ++E +AS ++ I Sbjct: 62 LQHPNIVRLHDSIQE----ESFHYLVFDLVTGGELFEDIVAR--EFYSEADASHCIQQIL 115 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVA 231 E+I Y HS I HR++KPENLL SK A +KL DFG A E + TP Y++ Sbjct: 116 ESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLS 175 Query: 232 PEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW 291 PEVL + Y K D+W+ GVI+YILL GYPPF+ + +I+ G Y++P+PEW Sbjct: 176 PEVLKKDPYSKPVDIWACGVILYILLVGYPPFWDEDQ----HRLYAQIKAGAYDYPSPEW 231 Query: 292 SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ--TPLHTSRVL 342 V+ E K LI ++L P +R+T + + PWI +V T L Sbjct: 232 DTVTPEAKSLIDSMLTVNPKKRITADQALKVPWICNRERVASAIHRQDTVDCL 284 >2JAM-A nrPDB Length = 304 Score = 312 bits (799), Expect = 2e-85, Method: Composition-based stats. Identities = 108/294 (36%), Positives = 166/294 (56%), Gaps = 22/294 (7%) Query: 65 VTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP-----KARREVELHWRASQCPHIVR 119 + +VLG G +V + + T + FALK ++ P E+ + + + +IV Sbjct: 12 IFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKI-KHENIVT 70 Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 + D+YE+ +VM+ + GGELF RI +RG +TE++AS +++ + A++YLH Sbjct: 71 LEDIYEST----THYYLVMQLVSGGELFDRILERG--VYTEKDASLVIQQVLSAVKYLHE 124 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEK 239 I HRD+KPENLLY + N+ + +TDFG +K + ++T C TP YVAPEVL + Sbjct: 125 NGIVHRDLKPENLLYLTPEENSKIMITDFGLSK-MEQNGIMSTACGTPGYVAPEVLAQKP 183 Query: 240 YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVK 299 Y K+ D WS+GVI YILLCGYPPFY + +I+ G YEF +P W ++SE K Sbjct: 184 YSKAVDCWSIGVITYILLCGYPPFYEETE----SKLFEKIKEGYYEFESPFWDDISESAK 239 Query: 300 MLIRNLLKTEPTQRMTITEFMNHPWIMQSTKV-----PQTPLHTSRVLKEDKER 348 I +LL+ +P +R T + ++HPWI +T + P L + + K R Sbjct: 240 DFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNFAKSKWR 293 >4FG9-A nrPDB Length = 320 Score = 311 bits (798), Expect = 3e-85, Method: Composition-based stats. Identities = 110/318 (34%), Positives = 178/318 (55%), Gaps = 18/318 (5%) Query: 50 SGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP------KARR 103 G + K+ I D VLG G +V+ +KRTQ+ A+K + Sbjct: 6 EGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMEN 65 Query: 104 EVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREA 163 E+ + + + P+IV + D+YE+ L ++M+ + GGELF RI ++G +TER+A Sbjct: 66 EIAVLHKI-KHPNIVALDDIYES----GGHLYLIMQLVSGGELFDRIVEKG--FYTERDA 118 Query: 164 SEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTP 223 S ++ + +A++YLH + I HRD+KPENLLY S ++ + ++DFG +K + L+T Sbjct: 119 SRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTA 178 Query: 224 CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQ 283 C TP YVAPEVL + Y K+ D WS+GVI YILLCGYPPFY + + +I + Sbjct: 179 CGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAK----LFEQILKAE 234 Query: 284 YEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQT-PLHTSRVL 342 YEF +P W ++S+ K IR+L++ +P +R T + + HPWI T + + S + Sbjct: 235 YEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQI 294 Query: 343 KEDKERWEDVKEEMTSAL 360 K++ + + + +A+ Sbjct: 295 KKNFAKSKWKQAFNATAV 312 >2JC6-A nrPDB Length = 334 Score = 311 bits (797), Expect = 4e-85, Method: Composition-based stats. Identities = 110/320 (34%), Positives = 176/320 (55%), Gaps = 17/320 (5%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELH-----WRASQCPHIVRI 120 + LG G +V+ K T + FA+K + +E + R + +IV + Sbjct: 26 FKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVAL 85 Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 D+YE+ L +VM+ + GGELF RI ++G +TE++AS +++ + +A+ YLH + Sbjct: 86 EDIYES----PNHLYLVMQLVSGGELFDRIVEKG--FYTEKDASTLIRQVLDAVYYLHRM 139 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY 240 I HRD+KPENLLY S+ + + ++DFG +K + ++T C TP YVAPEVL + Y Sbjct: 140 GIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPY 199 Query: 241 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 300 K+ D WS+GVI YILLCGYPPFY + + +I +YEF +P W ++S+ K Sbjct: 200 SKAVDCWSIGVIAYILLCGYPPFYDEN----DSKLFEQILKAEYEFDSPYWDDISDSAKD 255 Query: 301 LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL 360 IRNL++ +P +R T + HPWI T + + +H S + K + + +A Sbjct: 256 FIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKN-IHESVSAQIRKNFAKSKWRQAFNAT 314 Query: 361 ATMRVDYEQIKIKKIEDASN 380 A +R ++ + D+SN Sbjct: 315 AVVR-HMRKLHLGSSLDSSN 333 >4JG6-A nrPDB Length = 355 Score = 302 bits (774), Expect = 2e-82, Method: Composition-based stats. Identities = 104/293 (35%), Positives = 170/293 (58%), Gaps = 13/293 (4%) Query: 53 QIKKNAI--IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKA-RREVELHW 109 Q+ +N+I D Y+V + +G+G + +K T +FA+K++ + E+E+ Sbjct: 25 QLHRNSIQFTDGYEV-KEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILL 83 Query: 110 RASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 169 R Q P+I+ + DVY++ K + +V E + GGEL +I + + F+EREAS ++ + Sbjct: 84 RYGQHPNIITLKDVYDD----GKYVYVVTELMKGGELLDKILRQ--KFFSEREASAVLFT 137 Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAI-LKLTDFGFAKETTSHNSL-TTPCYTP 227 I + ++YLH+ + HRD+KP N+LY + N +++ DFGFAK+ + N L TPCYT Sbjct: 138 ITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTA 197 Query: 228 YYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 +VAPEVL + YD +CD+WSLGV++Y +L GY PF +N + RI G++ Sbjct: 198 NFVAPEVLERQGYDAACDIWSLGVLLYTMLTGYTPF-ANGPDDTPEEILARIGSGKFSLS 256 Query: 288 NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSR 340 W+ VS+ K L+ +L +P QR+T + HPWI+ ++PQ L+ Sbjct: 257 GGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQD 309 >3TAC-A nrPDB Length = 361 Score = 297 bits (760), Expect = 7e-81, Method: Composition-based stats. Identities = 98/327 (29%), Positives = 156/327 (47%), Gaps = 25/327 (7%) Query: 48 VKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ----------D 97 V G + + +D +V+G G V + N+ T ++FA+K++ Sbjct: 12 VPRGSMADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLS 71 Query: 98 CPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQA 157 +RE + + PHIV +++ Y + L +V E +DG +L I R D Sbjct: 72 TEDLKREASI-CHMLKHPHIVELLETYSS----DGMLYMVFEFMDGADLCFEIVKRADAG 126 Query: 158 F--TEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT 215 F +E AS M+ I EA++Y H NI HRDVKP +L SK +A +KL FG A + Sbjct: 127 FVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLG 186 Query: 216 SHNSLT-TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPG 274 + TP+++APEV+ E Y K D+W GVI++ILL G PFY Sbjct: 187 ESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYG-----TKER 241 Query: 275 MKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTK--VP 332 + I G+Y+ +WS +SE K L+R +L +P +R+T+ E +NHPW+ + + Sbjct: 242 LFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYK 301 Query: 333 QTPLHTSRVLKEDKERWEDVKEEMTSA 359 T L++ R + + + Sbjct: 302 IHLPETVEQLRKFNARRKLKGAVLAAV 328 >4REW-A nrPDB Length = 540 Score = 297 bits (760), Expect = 7e-81, Method: Composition-based stats. Identities = 94/319 (29%), Positives = 153/319 (47%), Gaps = 35/319 (10%) Query: 63 YKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP--------KARREVELHWRASQC 114 + + LG+G GKV ++ T K A+K+L K RRE++ + + + Sbjct: 7 HYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQ-NLKLFRH 65 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 PHI+++ V + + +VME + GGELF I G E+E+ + + I + Sbjct: 66 PHIIKLYQVI----STPSDIFMVMEYVSGGELFDYICKNG--RLDEKESRRLFQQILSGV 119 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV 234 Y H + HRD+KPEN+L + + K+ DFG + + L T C +P Y APEV Sbjct: 120 DYCHRHMVVHRDLKPENVLLDA---HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV 176 Query: 235 LGPEKY-DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSE 293 + Y D+WS GVI+Y LLCG PF +H + + I F P++ Sbjct: 177 ISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGI------FYTPQY-- 228 Query: 294 VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKV---PQTPLHTS-----RVLKED 345 ++ V L++++L+ +P +R +I + H W Q P+ P ++S LKE Sbjct: 229 LNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEV 288 Query: 346 KERWEDVKEEMTSALATMR 364 E++E +EE+ S L Sbjct: 289 CEKFECSEEEVLSCLYNRN 307 >3KN6-A nrPDB Length = 325 Score = 294 bits (754), Expect = 4e-80, Method: Composition-based stats. Identities = 98/287 (34%), Positives = 162/287 (56%), Gaps = 12/287 (4%) Query: 62 DYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKA--RREVELHWRASQCPHIVR 119 D + + LG G + +K++ + FA+K++ +A ++E+ P+IV+ Sbjct: 11 DLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVK 70 Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 + +V+ + +VME L+GGELF RI+ + + F+E EAS IM+ + A+ ++H Sbjct: 71 LHEVFHDQLHT----FLVMELLNGGELFERIKKK--KHFSETEASYIMRKLVSAVSHMHD 124 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS-LTTPCYTPYYVAPEVLGPE 238 + + HRD+KPENLL+T + N +K+ DFGFA+ N L TPC+T +Y APE+L Sbjct: 125 VGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQN 184 Query: 239 KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISP---GMKTRIRMGQYEFPNPEWSEVS 295 YD+SCD+WSLGVI+Y +L G PF S+ + +I+ G + F W VS Sbjct: 185 GYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVS 244 Query: 296 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVL 342 +E K LI+ LL +P +R+ ++ + W+ +++ PL T +L Sbjct: 245 QEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDIL 291 >4CFF-A nrPDB Length = 571 Score = 294 bits (754), Expect = 4e-80, Method: Composition-based stats. Identities = 97/325 (29%), Positives = 153/325 (47%), Gaps = 35/325 (10%) Query: 53 QIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP--------KARRE 104 Q + + V LG+G GKV ++ T K A+K+L K +RE Sbjct: 24 QKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKRE 83 Query: 105 VELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREAS 164 ++ + + + PHI+++ V + +VME + GGELF I G E EA Sbjct: 84 IQ-NLKLFRHPHIIKLYQVI----STPTDFFMVMEYVSGGELFDYICKHG--RVEEMEAR 136 Query: 165 EIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPC 224 + + I A+ Y H + HRD+KPEN+L + + K+ DFG + + L T C Sbjct: 137 RLFQQILSAVDYCHRHMVVHRDLKPENVLLDA---HMNAKIADFGLSNMMSDGEFLRTSC 193 Query: 225 YTPYYVAPEVLGPEKY-DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQ 283 +P Y APEV+ Y D+WS GVI+Y LLCG PF H P + +IR G Sbjct: 194 GSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEH----VPTLFKKIRGGV 249 Query: 284 YEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTK---VPQTPLHTSR 340 + P ++ V L+ ++L+ +P +R TI + H W Q P+ P + + Sbjct: 250 FYIPE----YLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDAN 305 Query: 341 VL-----KEDKERWEDVKEEMTSAL 360 V+ KE E++E + E+ ++L Sbjct: 306 VIDDEAVKEVCEKFECTESEVMNSL 330 >5EZV-A nrPDB Length = 560 Score = 294 bits (752), Expect = 5e-80, Method: Composition-based stats. Identities = 97/325 (29%), Positives = 153/325 (47%), Gaps = 35/325 (10%) Query: 53 QIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP--------KARRE 104 Q + + V LG+G GKV ++ T K A+K+L K +RE Sbjct: 19 QKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKRE 78 Query: 105 VELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREAS 164 ++ + + + PHI+++ V + +VME + GGELF I G E EA Sbjct: 79 IQ-NLKLFRHPHIIKLYQVI----STPTDFFMVMEYVSGGELFDYICKHG--RVEEMEAR 131 Query: 165 EIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPC 224 + + I A+ Y H + HRD+KPEN+L + + K+ DFG + + L T C Sbjct: 132 RLFQQILSAVDYCHRHMVVHRDLKPENVLLDA---HMNAKIADFGLSNMMSDGEFLRTSC 188 Query: 225 YTPYYVAPEVLGPEKY-DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQ 283 +P Y APEV+ Y D+WS GVI+Y LLCG PF H P + +IR G Sbjct: 189 GSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEH----VPTLFKKIRGGV 244 Query: 284 YEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTK---VPQTPLHTSR 340 + P ++ V L+ ++L+ +P +R TI + H W Q P+ P + + Sbjct: 245 FYIPE----YLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDAN 300 Query: 341 VL-----KEDKERWEDVKEEMTSAL 360 V+ KE E++E + E+ ++L Sbjct: 301 VIDDEAVKEVCEKFECTESEVMNSL 325 >4CFH-A nrPDB Length = 493 Score = 294 bits (752), Expect = 5e-80, Method: Composition-based stats. Identities = 96/329 (29%), Positives = 155/329 (47%), Gaps = 35/329 (10%) Query: 53 QIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP--------KARRE 104 Q + + + LG+G GKV ++ T K A+K+L K RRE Sbjct: 24 QKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRRE 83 Query: 105 VELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREAS 164 ++ + + + PHI+++ V + + +VME + GGELF I G E+E+ Sbjct: 84 IQ-NLKLFRHPHIIKLYQVI----STPSDIFMVMEYVSGGELFDYICKNG--RLDEKESR 136 Query: 165 EIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPC 224 + + I + Y H + HRD+KPEN+L + + K+ DFG + + L T C Sbjct: 137 RLFQQILSGVDYCHRHMVVHRDLKPENVLLDA---HMNAKIADFGLSNMMSDGEFLRTSC 193 Query: 225 YTPYYVAPEVLGPEKY-DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQ 283 +P Y APEV+ Y D+WS GVI+Y LLCG PF +H + + I Sbjct: 194 GSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGI---- 249 Query: 284 YEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKV---PQTPLHTS- 339 F P++ ++ V L++++L+ +P +R TI + H W Q P+ P ++S Sbjct: 250 --FYTPQY--LNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSST 305 Query: 340 ----RVLKEDKERWEDVKEEMTSALATMR 364 LKE E++E +EE+ S L Sbjct: 306 MIDDEALKEVCEKFECSEEEVLSCLYNRN 334 >5WAX-A nrPDB Length = 310 Score = 294 bits (752), Expect = 6e-80, Method: Composition-based stats. Identities = 92/292 (31%), Positives = 145/292 (49%), Gaps = 18/292 (6%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKA----RREVELHWRASQCPH 116 D Y++ +G G G + N+ + A+K ++ K +RE+ ++ R+ + P+ Sbjct: 11 DRYELVRD-IGSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQREI-INHRSLRHPN 68 Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 I+R +V L IVME GGELF RI + G F+E EA + + + Y Sbjct: 69 IIRFKEVI----LTPTHLAIVMEYASGGELFERICNAG--RFSEDEARFFFQQLISGVSY 122 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 236 HS+ + HRD+K EN L LK+ DFG++K + H+ + TP Y+APEVL Sbjct: 123 CHSMQVCHRDLKLENTLLDGSTA-PRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 181 Query: 237 PEKYDKSC-DMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 295 ++YD D+WS GV +Y++L G PF RI QY P ++ +S Sbjct: 182 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIP--DYVHIS 239 Query: 296 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKE 347 E + LI + P R+TI E NHPW +++ +P + S + K+ +E Sbjct: 240 PECQDLISRIFVANPATRITIPEIRNHPWFLKN--LPADLMDDSTMSKQYEE 289 >2YCR-A nrPDB Length = 323 Score = 293 bits (751), Expect = 8e-80, Method: Composition-based stats. Identities = 98/302 (32%), Positives = 154/302 (50%), Gaps = 31/302 (10%) Query: 62 DYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKA-------------RREVELH 108 D + S+ LG G G+V F ++T +K A+K++ A E+E+ Sbjct: 10 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 69 Query: 109 WRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMK 168 + P I++I + ++ + IV+E ++GGELF ++ G++ E Sbjct: 70 KKL-NHPCIIKIKNFFDA-----EDYYIVLELMEGGELFDKVV--GNKRLKEATCKLYFY 121 Query: 169 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY 228 + A+QYLH I HRD+KPEN+L +S+ + ++K+TDFG +K + + T C TP Sbjct: 122 QMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPT 181 Query: 229 YVAPEVL---GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE 285 Y+APEVL G Y+++ D WSLGVI++I L GYPPF +K +I G+Y Sbjct: 182 YLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPF---SEHRTQVSLKDQITSGKYN 238 Query: 286 FPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKED 345 F W+EVSE+ L++ LL +P R T E + HPW+ +L E+ Sbjct: 239 FIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDE----DMKRKFQDLLSEE 294 Query: 346 KE 347 E Sbjct: 295 NE 296 >4RED-A nrPDB Length = 351 Score = 292 bits (749), Expect = 1e-79, Method: Composition-based stats. Identities = 92/319 (28%), Positives = 152/319 (47%), Gaps = 35/319 (10%) Query: 63 YKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP--------KARREVELHWRASQC 114 + + LG+G GKV ++ T A+K+L K RRE++ + + + Sbjct: 15 HYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQ-NLKLFRH 73 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 PHI+++ V + + +VME + GGELF I G E+E+ + + I + Sbjct: 74 PHIIKLYQVI----STPSDIFMVMEYVSGGELFDYICKNG--RLDEKESRRLFQQILSGV 127 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV 234 Y H + HRD+KPEN+L + + K+ DFG + + L T C +P Y APEV Sbjct: 128 DYCHRHMVVHRDLKPENVLLDA---HMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV 184 Query: 235 LGPEKY-DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSE 293 + Y D+WS GVI+Y LLCG PF +H + + I F P++ Sbjct: 185 ISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGI------FYTPQY-- 236 Query: 294 VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKV---PQTPLHTS-----RVLKED 345 ++ V L++++L+ +P +R +I + H W Q P+ P +++ LKE Sbjct: 237 LNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQDLPKYLFPEDPSYSTTMIDDEALKEV 296 Query: 346 KERWEDVKEEMTSALATMR 364 E++E +EE+ S L Sbjct: 297 CEKFECSEEEVLSCLYNRN 315 >3F3Z-A nrPDB Length = 277 Score = 292 bits (747), Expect = 2e-79, Method: Composition-based stats. Identities = 101/283 (35%), Positives = 153/283 (54%), Gaps = 18/283 (6%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-----QDCPKARREVELHWRASQC 114 I+ Y +G G G+V K T+ + A K + +D + ++E+E+ ++ Sbjct: 7 INQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDRFKQEIEIM-KSLDH 65 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 P+I+R+ + +E+ + +VME GGELF R+ + + F E +A+ IMK + A+ Sbjct: 66 PNIIRLYETFED----NTDIYLVMELCTGGELFERVVHK--RVFRESDAARIMKDVLSAV 119 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV 234 Y H +N+AHRD+KPEN L+ + P++ LKL DFG A + T TPYYV+P+V Sbjct: 120 AYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQV 179 Query: 235 LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 294 L Y CD WS GV+MY+LLCGYPPF + +IR G + FP +W V Sbjct: 180 LEG-LYGPECDEWSAGVMMYVLLCGYPPF----SAPTDSEVMLKIREGTFTFPEKDWLNV 234 Query: 295 SEEVKMLIRNLLKTEPTQRMTITEFMNHPWI-MQSTKVPQTPL 336 S + + LIR LL P QR+T + + H W Q + P+ L Sbjct: 235 SPQAESLIRRLLTKSPKQRITSLQALEHEWFEKQLSSSPRNLL 277 >3I6U-A nrPDB Length = 419 Score = 291 bits (744), Expect = 5e-79, Method: Composition-based stats. Identities = 94/283 (33%), Positives = 149/283 (52%), Gaps = 27/283 (9%) Query: 62 DYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKA-------------RREVELH 108 D + S+ LG G G+V F ++T +K A++++ A E+E+ Sbjct: 135 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEIL 194 Query: 109 WRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMK 168 + P I++I + ++ + IV+E ++GGELF ++ G++ E Sbjct: 195 KKL-NHPCIIKIKNFFDA-----EDYYIVLELMEGGELFDKVV--GNKRLKEATCKLYFY 246 Query: 169 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY 228 + A+QYLH I HRD+KPEN+L +S+ + ++K+TDFG +K + + T C TP Sbjct: 247 QMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPT 306 Query: 229 YVAPEVL---GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE 285 Y+APEVL G Y+++ D WSLGVI++I L GYPPF +K +I G+Y Sbjct: 307 YLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPF---SEHRTQVSLKDQITSGKYN 363 Query: 286 FPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328 F W+EVSE+ L++ LL +P R T E + HPW+ Sbjct: 364 FIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDE 406 >3ZUT-A nrPDB Length = 362 Score = 288 bits (737), Expect = 3e-78, Method: Composition-based stats. Identities = 91/302 (30%), Positives = 149/302 (49%), Gaps = 17/302 (5%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKA----RREVELHWRASQCPH 116 D Y++ +G G G + +K++ E A+K ++ K +RE+ ++ R+ + P+ Sbjct: 19 DRYELVKD-IGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREI-INHRSLRHPN 76 Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 IVR +V L IVME GGELF RI + G F+E EA + + + Y Sbjct: 77 IVRFKEVI----LTPTHLAIVMEYASGGELFERICNAG--RFSEDEARFFFQQLISGVSY 130 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 236 H++ + HRD+K EN L P LK+ FG++K + H+ + TP Y+APEVL Sbjct: 131 CHAMQVCHRDLKLENTLLD-GSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 189 Query: 237 PEKYDKSC-DMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 295 ++YD D+WS GV +Y++L G PF RI QY P ++ +S Sbjct: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP--DYVHIS 247 Query: 296 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHT-SRVLKEDKERWEDVKE 354 E + LI + +P +R++I E NH W +++ +T + E + + ++E Sbjct: 248 PECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEE 307 Query: 355 EM 356 M Sbjct: 308 IM 309 >2HW6-A nrPDB Length = 307 Score = 287 bits (734), Expect = 8e-78, Method: Composition-based stats. Identities = 98/304 (32%), Positives = 159/304 (52%), Gaps = 35/304 (11%) Query: 57 NAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD-----CPKARREVELHWRA 111 D YK+TS++LG G KV + + +++A+K+++ + REVE ++ Sbjct: 8 GKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQC 67 Query: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 +I+ +++ +E+ +V E L GG + + IQ + + F EREAS +++ + Sbjct: 68 QGNKNILELIEFFED----DTRFYLVFEKLQGGSILAHIQKQ--KHFNEREASRVVRDVA 121 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--------LTTP 223 A+ +LH+ IAHRD+KPEN+L S + +K+ DF +NS LTTP Sbjct: 122 AALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTP 181 Query: 224 CYTPYYVAPEVL-----GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAI------- 271 C + Y+APEV+ YDK CD+WSLGV++YI+L GYPPF + G Sbjct: 182 CGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEV 241 Query: 272 ----SPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 + I+ G+YEFP+ +W+ +S E K LI LL + QR++ + + HPW+ Sbjct: 242 CRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQG 301 Query: 328 STKV 331 Sbjct: 302 QAPE 305 >2X4F-A nrPDB Length = 373 Score = 287 bits (734), Expect = 8e-78, Method: Composition-based stats. Identities = 101/345 (29%), Positives = 168/345 (48%), Gaps = 31/345 (8%) Query: 19 PPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTS-QVLGLGINGK 77 P T AL A P PP F V + K+ A+ Y V+ ++LG G G+ Sbjct: 53 PVKSKRTSAL----AVDIPAPPAPFDHRIVTA----KQGAVNSFYTVSKTEILGGGRFGQ 104 Query: 78 VLQIFNKRTQEKFALKMLQ-----DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRK 132 V + T K A K+++ D + + E+ + + +++++ D +E+ + Sbjct: 105 VHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQL-DHANLIQLYDAFES----KN 159 Query: 133 CLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENL 192 +++VME +DGGELF RI D TE + MK I E I+++H + I H D+KPEN+ Sbjct: 160 DIVLVMEYVDGGELFDRIIDESYN-LTELDTILFMKQICEGIRHMHQMYILHLDLKPENI 218 Query: 193 LYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVI 252 L ++ +K+ DFG A+ L TP ++APEV+ + DMWS+GVI Sbjct: 219 LCVNRDAKQ-IKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVI 277 Query: 253 MYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQ 312 Y+LL G PF ++ I +++ + E+ ++SEE K I LL E + Sbjct: 278 AYMLLSGLSPFLGDNDAET----LNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSW 333 Query: 313 RMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMT 357 R++ +E + HPW+ LH+ ++ K R D ++ +T Sbjct: 334 RISASEALKHPWLS------DHKLHSRLSAQKKKNRGSDAQDFVT 372 >2YAB-A nrPDB Length = 361 Score = 286 bits (732), Expect = 1e-77, Method: Composition-based stats. Identities = 103/348 (29%), Positives = 163/348 (46%), Gaps = 29/348 (8%) Query: 51 GLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC-----------P 99 G++ K ++D+ + LG G V + K T ++A K ++ Sbjct: 1 GMETFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCRE 60 Query: 100 KARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFT 159 + REV + + P+I+ + DVYEN R +++++E + GGELF + + ++ + Sbjct: 61 EIEREVSILRQVL-HPNIITLHDVYEN----RTDVVLILELVSGGELFDFLAQK--ESLS 113 Query: 160 EREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKR-PNAILKLTDFGFAKETTSHN 218 E EA+ +K I + + YLH+ IAH D+KPEN++ K P +KL DFG A E Sbjct: 114 EEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGV 173 Query: 219 SLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTR 278 TP +VAPE++ E DMWS+GVI YILL G PF + Sbjct: 174 EFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGD----TKQETLAN 229 Query: 279 IRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI----MQSTKVPQT 334 I Y+F +S+ SE K IR LL E +R+TI E + HPWI Q V + Sbjct: 230 ITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDTQQAMVRRE 289 Query: 335 PLHTSRVLKED--KERWEDVKEEMTSALATMRVDYEQIKIKKIEDASN 380 + K+ + RW+ ++ R +++ ++ ED N Sbjct: 290 SVVNLENFKKQYVRRRWKLSFSIVSLCNHLTRSLMKKVHLRTSEDLRN 337 >2J90-A nrPDB Length = 304 Score = 284 bits (727), Expect = 4e-77, Method: Composition-based stats. Identities = 93/282 (32%), Positives = 146/282 (51%), Gaps = 23/282 (8%) Query: 57 NAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC-----------PKARREV 105 ++++D+ + LG G V + K T +++A K ++ + REV Sbjct: 21 QSMVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREV 80 Query: 106 ELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASE 165 + R + P+I+ + D++EN + +++++E + GGELF + ++ ++ TE EA++ Sbjct: 81 NI-LREIRHPNIITLHDIFEN----KTDVVLILELVSGGELFDFLAEK--ESLTEDEATQ 133 Query: 166 IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKR-PNAILKLTDFGFAKETTSHNSLTTPC 224 +K I + + YLHS IAH D+KPEN++ K PN +KL DFG A + + N Sbjct: 134 FLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIF 193 Query: 225 YTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQY 284 TP +VAPE++ E DMWS+GVI YILL G PF T I Y Sbjct: 194 GTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGE----TKQETLTNISAVNY 249 Query: 285 EFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIM 326 +F +S SE K IR LL +P +RMTI + + H WI Sbjct: 250 DFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIK 291 >3UDB-A nrPDB Length = 317 Score = 284 bits (727), Expect = 5e-77, Method: Composition-based stats. Identities = 93/302 (30%), Positives = 150/302 (49%), Gaps = 17/302 (5%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKA----RREVELHWRASQCPH 116 D Y++ +G G G + +K+ E A+K ++ K +RE+ ++ R+ + P+ Sbjct: 19 DRYELVKD-IGAGNFGVARLMRDKQANELVAVKYIERGEKIDENVKREI-INHRSLRHPN 76 Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 IVR +V L IVME GGELF RI + G F+E EA + + + Y Sbjct: 77 IVRFKEVI----LTPTHLAIVMEYASGGELFERICNAG--RFSEDEARFFFQQLISGVSY 130 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 236 H++ +AHRD+K EN L P LK+ DFG++K + H+ + TP Y+APEVL Sbjct: 131 AHAMQVAHRDLKLENTLLD-GSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLL 189 Query: 237 PEKYDKSC-DMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 295 ++YD D+WS GV +Y++L G PF RI QY P ++ +S Sbjct: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIP--DYVHIS 247 Query: 296 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHT-SRVLKEDKERWEDVKE 354 E + LI + +P +R++I E NH W +++ +T + E + + ++E Sbjct: 248 PECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMNDNTMTTQFDESDQPGQSIEE 307 Query: 355 EM 356 M Sbjct: 308 IM 309 >5JZN-A nrPDB Length = 280 Score = 284 bits (727), Expect = 5e-77, Method: Composition-based stats. Identities = 103/288 (35%), Positives = 153/288 (53%), Gaps = 20/288 (6%) Query: 45 QFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP----- 99 + + G QI I + YKV + +G G V + + T ++ALK+++ Sbjct: 4 EEVSEEGFQIPAT-ITERYKV-GRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKE 61 Query: 100 -KARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAF 158 + EV + R + P+IV +++ L +VME + GG+LF I + Sbjct: 62 HMIQNEVSILRRV-KHPNIVLLIE----EMDVPTELYLVMELVKGGDLFDAITS--TNKY 114 Query: 159 TEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLY-TSKRPNAILKLTDFGFAKETTSH 217 TER+AS ++ ++ AI+YLHS+NI HRD+KPENLL + + LKL DFG A T Sbjct: 115 TERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLA--TIVD 172 Query: 218 NSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKT 277 L T C TP YVAPE++ Y D+W+ GVI YILLCG+PPF + + Sbjct: 173 GPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQ--EVLFD 230 Query: 278 RIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 +I MGQ +FP+P W VS+ K LI +L + QR + + + HPW+ Sbjct: 231 QILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWV 278 >3UC3-A nrPDB Length = 361 Score = 283 bits (725), Expect = 7e-77, Method: Composition-based stats. Identities = 89/292 (30%), Positives = 141/292 (48%), Gaps = 18/292 (6%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC----PKARREVELHWRASQCPH 116 D Y +G G G + +K T+E A+K ++ +RE+ ++ R+ + P+ Sbjct: 20 DRYDFVKD-IGSGNFGVARLMRDKLTKELVAVKYIERGAAIDENVQREI-INHRSLRHPN 77 Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 IVR +V L I+ME GGEL+ RI + G F+E EA + + + Y Sbjct: 78 IVRFKEVI----LTPTHLAIIMEYASGGELYERICNAG--RFSEDEARFFFQQLLSGVSY 131 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 236 HS+ I HRD+K EN L P LK+ DFG++K + H+ + TP Y+APEVL Sbjct: 132 CHSMQICHRDLKLENTLLD-GSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 190 Query: 237 PEKYDKS-CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 295 ++YD D+WS GV +Y++L G PF RI +Y P + +S Sbjct: 191 RQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIP--DDIRIS 248 Query: 296 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKE 347 E LI + +P R++I E H W +++ +P ++ S + +E Sbjct: 249 PECCHLISRIFVADPATRISIPEIKTHSWFLKN--LPADLMNESNTGSQFQE 298 >5XZW-A nrPDB Length = 471 Score = 283 bits (725), Expect = 8e-77, Method: Composition-based stats. Identities = 92/302 (30%), Positives = 149/302 (49%), Gaps = 31/302 (10%) Query: 48 VKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKA------ 101 S + K I D+ + +V+G G V + + T + FA+K++ Sbjct: 182 TASSMVANKTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGV 241 Query: 102 RREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTER 161 RE+E+ + P IVR+ YE+ + +VME + GG+L + G A E Sbjct: 242 TRELEVLQKL-NHPRIVRLKGFYEDT----ESYYMVMEFVSGGDLMDFVAAHG--AVGED 294 Query: 162 EASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT 221 EI + I AI+Y+HS+ I+HRD+KP+N+L P ++K+TDFG AK + + + Sbjct: 295 AGREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDP-VLVKITDFGLAKVQGNGSFMK 353 Query: 222 TPCYTPYYVAPEVLGPE-------------KYDKSCDMWSLGVIMYILLCGYPPFYSNHG 268 T C T YVAPEV+ + +Y DMWS+G ++Y++L G+ PF Sbjct: 354 TFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSG--- 410 Query: 269 LAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328 + + +I G Y + +SEE + I +LL+ +P R T + +NHPWI+ S Sbjct: 411 -STQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWIVDS 469 Query: 329 TK 330 + Sbjct: 470 SN 471 >5YKS-A nrPDB Length = 377 Score = 283 bits (724), Expect = 9e-77, Method: Composition-based stats. Identities = 101/337 (29%), Positives = 165/337 (48%), Gaps = 29/337 (8%) Query: 50 SGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP-------KAR 102 +G + + I + LG G V + T EK A+K++ Sbjct: 23 AGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLF 82 Query: 103 REVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTERE 162 +EV + Q P+IVR+ +V + + L +++E DGG++F I ++ E Sbjct: 83 QEVRCM-KLVQHPNIVRLYEVIDT----QTKLYLILELGDGGDMFDYIMKH-EEGLNEDL 136 Query: 163 ASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTT 222 A + I AI Y H +++ HRD+KPEN+++ K+ ++KLTDFGF+ + LTT Sbjct: 137 AKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQ--GLVKLTDFGFSNKFQPGKKLTT 194 Query: 223 PCYTPYYVAPEVLGPEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRM 281 C + Y APE+L ++YD + D+WSLGVI+++L+CG PPF A T I Sbjct: 195 SCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQE----ANDSETLTMIMD 250 Query: 282 GQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQT----PLH 337 +Y P S VS+E K LI +L+ +P +R ++ E NHPW+ P T PL Sbjct: 251 CKYTVP----SHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLV 306 Query: 338 TSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKK 374 + + L E+ E ++ + +A E ++ + Sbjct: 307 SYKNLSEE-EHNSIIQRMVLGDIADRDAIVEALETNR 342 >6CKI-A nrPDB Length = 316 Score = 282 bits (723), Expect = 1e-76, Method: Composition-based stats. Identities = 98/317 (30%), Positives = 154/317 (48%), Gaps = 37/317 (11%) Query: 56 KNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP-----KARREVELHWR 110 D Y++ VLG G + +V N T +++A+K+++ P + REVE+ ++ Sbjct: 7 SGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQ 66 Query: 111 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 ++ + +V E + GG + S I R + F E EAS +++ + Sbjct: 67 CQGHRNV----LELIEFFEEEDRFYLVFEKMRGGSILSHIHKR--RHFNELEASVVVQDV 120 Query: 171 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT--------T 222 A+ +LH+ IAHRD+KPEN+L + +K+ DFG + + T Sbjct: 121 ASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLT 180 Query: 223 PCYTPYYVAPEVL-----GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL-------- 269 PC + Y+APEV+ YDK CD+WSLGVI+YILL GYPPF G Sbjct: 181 PCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGE 240 Query: 270 ---AISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIM 326 A + I+ G+YEFP+ +W+ +S K LI LL + QR++ + + HPW+ Sbjct: 241 ACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQ 300 Query: 327 QSTKVPQTPLHTSRVLK 343 P+ L T VL+ Sbjct: 301 GCA--PENTLPTPMVLQ 315 >2A27-A nrPDB Length = 321 Score = 282 bits (723), Expect = 1e-76, Method: Composition-based stats. Identities = 92/288 (31%), Positives = 141/288 (48%), Gaps = 23/288 (7%) Query: 51 GLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC-----------P 99 G++ K ++D+ + LG G V + K T ++A K ++ Sbjct: 1 GMEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSRE 60 Query: 100 KARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFT 159 + REV + + +++ + DVYEN R +++++E + GGELF + + ++ + Sbjct: 61 EIEREVSILRQVLHH-NVITLHDVYEN----RTDVVLILELVSGGELFDFLAQK--ESLS 113 Query: 160 EREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKR-PNAILKLTDFGFAKETTSHN 218 E EA+ +K I + + YLH+ IAH D+KPEN++ K P +KL DFG A E Sbjct: 114 EEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGV 173 Query: 219 SLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTR 278 TP +VAPE++ E DMWS+GVI YILL G PF + Sbjct: 174 EFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGD----TKQETLAN 229 Query: 279 IRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIM 326 I Y+F +S+ SE K IR LL E +R+TI E + HPWI Sbjct: 230 ITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT 277 >3GUB-A nrPDB Length = 295 Score = 282 bits (722), Expect = 2e-76, Method: Composition-based stats. Identities = 94/287 (32%), Positives = 143/287 (49%), Gaps = 23/287 (8%) Query: 52 LQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC-----------PK 100 + + + +DDY T + LG G V + K T ++A K ++ Sbjct: 1 MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSRED 60 Query: 101 ARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTE 160 REV + + Q P+++ + +VYEN + ++++ E + GGELF + ++ ++ TE Sbjct: 61 IEREVSI-LKEIQHPNVITLHEVYEN----KTDVILIGELVAGGELFDFLAEK--ESLTE 113 Query: 161 REASEIMKSIGEAIQYLHSINIAHRDVKPENL-LYTSKRPNAILKLTDFGFAKETTSHNS 219 EA+E +K I + YLHS+ IAH D+KPEN+ L P +K+ DFG A + N Sbjct: 114 EEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNE 173 Query: 220 LTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRI 279 TP +VAPE++ E DMWS+GVI YILL G PF + + Sbjct: 174 FKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGD----TKQETLANV 229 Query: 280 RMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIM 326 YEF + +S S K IR LL +P +RMTI + + HPWI Sbjct: 230 SAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIK 276 >1ZWS-A nrPDB Length = 288 Score = 282 bits (722), Expect = 2e-76, Method: Composition-based stats. Identities = 92/288 (31%), Positives = 140/288 (48%), Gaps = 23/288 (7%) Query: 51 GLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC-----------P 99 G++ K ++D+ + LG G V + K T ++A K ++ Sbjct: 1 GMEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSRE 60 Query: 100 KARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFT 159 + REV + + +++ + DVYEN R +++++E + GGELF + + ++ + Sbjct: 61 EIEREVSILRQVLHH-NVITLHDVYEN----RTDVVLILELVSGGELFDFLAQK--ESLS 113 Query: 160 EREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKR-PNAILKLTDFGFAKETTSHN 218 E EA+ +K I + + YLH+ IAH D+KPEN++ K P +KL DFG A E Sbjct: 114 EEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGV 173 Query: 219 SLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTR 278 TP +VAPE++ E DMWS+GVI YILL G PF + Sbjct: 174 EFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGD----TKQETLAN 229 Query: 279 IRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIM 326 I Y+F +S SE K IR LL E +R+TI E + HPWI Sbjct: 230 ITSVSYDFDEEFFSHTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT 277 >1PHK-A nrPDB Length = 298 Score = 281 bits (719), Expect = 4e-76, Method: Composition-based stats. Identities = 93/291 (31%), Positives = 153/291 (52%), Gaps = 34/291 (11%) Query: 57 NAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML----------QDCPKAR---- 102 + ++Y+ ++LG G++ V + +K T +++A+K++ ++ + R Sbjct: 13 HGFYENYE-PKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATL 71 Query: 103 REVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTERE 162 +EV++ + S P+I+++ D YE +V + + GELF + ++ +E+E Sbjct: 72 KEVDILRKVSGHPNIIQLKDTYET----NTFFFLVFDLMKKGELFDYLTEK--VTLSEKE 125 Query: 163 ASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTT 222 +IM+++ E I LH +NI HRD+KPEN+L + +KLTDFGF+ + L Sbjct: 126 TRKIMRALLEVICALHKLNIVHRDLKPENILLDD---DMNIKLTDFGFSCQLDPGEKLRE 182 Query: 223 PCYTPYYVAPEVLGPE------KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMK 276 C TP Y+APE++ Y K DMWS GVIMY LL G PPF+ + M Sbjct: 183 VCGTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQML----ML 238 Query: 277 TRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 I G Y+F +PEW + S+ VK L+ L +P +R T E + HP+ Q Sbjct: 239 RMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQKRYTAEEALAHPFFQQ 289 >5ES1-A nrPDB Length = 328 Score = 278 bits (711), Expect = 4e-75, Method: Composition-based stats. Identities = 93/322 (28%), Positives = 153/322 (47%), Gaps = 38/322 (11%) Query: 57 NAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP-------KARREVELHW 109 + +Y++ + +G G KV + T + A+K++ K REV + Sbjct: 11 QPHVGNYRLL-RTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIM- 68 Query: 110 RASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 169 + P+IV++ +V E K L +VME GE+F + G E+EA + Sbjct: 69 KGLNHPNIVKLFEVIET----EKTLYLVMEYASAGEVFDYLVSHG--RMKEKEARAKFRQ 122 Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYY 229 I A+ Y H NI HRD+K ENLL ++ A +K+ DFGF+ E T + L T C +P Y Sbjct: 123 IVSAVHYCHQKNIVHRDLKAENLLLDAE---ANIKIADFGFSNEFTLGSKLDTFCGSPPY 179 Query: 230 VAPEVLGPEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN 288 APE+ +KYD D+WSLGVI+Y L+ G PF ++ ++ R+ G+Y P Sbjct: 180 AAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHN----LKELRERVLRGKYRVPF 235 Query: 289 PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI--------MQSTKVPQTPLHTSR 340 +S + + ++R L P +R T+ + M WI ++ P+ ++ Sbjct: 236 ----YMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTK 291 Query: 341 VLK---EDKERWEDVKEEMTSA 359 ++ E++KE +TS Sbjct: 292 RIEVMVGMGYTREEIKESLTSQ 313 >2YZA-A nrPDB Length = 276 Score = 278 bits (711), Expect = 4e-75, Method: Composition-based stats. Identities = 86/283 (30%), Positives = 132/283 (46%), Gaps = 27/283 (9%) Query: 55 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP--------KARREVE 106 + + V LG+G GKV ++ T K A+K+L K +RE++ Sbjct: 4 HDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQ 63 Query: 107 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 + + + PHI+++ V + +VME + GGELF I G E EA + Sbjct: 64 -NLKLFRHPHIIKLYQVI----STPTDFFMVMEYVSGGELFDYICKHG--RVEEMEARRL 116 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 226 + I A+ Y H + HRD+KPEN+L + + K+ DFG + + L C + Sbjct: 117 FQQILSAVDYCHRHMVVHRDLKPENVLLDA---HMNAKIADFGLSNMMSDGEFLRDSCGS 173 Query: 227 PYYVAPEVLGPEKY-DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE 285 P Y APEV+ Y D+WS GVI+Y LLCG PF H P + +IR G + Sbjct: 174 PNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEH----VPTLFKKIRGGVFY 229 Query: 286 FPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328 P ++ V L+ ++L+ +P +R TI + H W Q Sbjct: 230 IPE----YLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQD 268 >3H4J-B nrPDB Length = 336 Score = 277 bits (710), Expect = 5e-75, Method: Composition-based stats. Identities = 92/326 (28%), Positives = 149/326 (45%), Gaps = 28/326 (8%) Query: 64 KVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC--------PKARREVELHWRASQCP 115 + + LG G GKV + +TQ+K ALK + + RE+ + + + P Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREIS-YLKLLRHP 69 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 HI+++ DV +++V+E GGELF I ++ + TE E + I AI+ Sbjct: 70 HIIKLYDVI----TTPTDIVMVIEYA-GGELFDYIVEK--KRMTEDEGRRFFQQIICAIE 122 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL 235 Y H I HRD+KPENLL N +K+ DFG + T N L T C +P Y APEV+ Sbjct: 123 YCHRHKIVHRDLKPENLLLDD---NLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVI 179 Query: 236 GPEKY-DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 294 + Y D+WS G+++Y++L G PF P + ++ Y P+ + Sbjct: 180 NGKLYAGPEVDVWSCGIVLYVMLVGRLPFDDE----FIPNLFKKVNSCVYVMPD----FL 231 Query: 295 SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKE 354 S + LIR ++ +P QR+TI E PW + P+ + D + E Sbjct: 232 SPGAQSLIRRMIVADPMQRITIQEIRRDPWFNVNLPDYLRPMEEVQGSYADSRIVSKLGE 291 Query: 355 EMTSALATMRVDYEQIKIKKIEDASN 380 M + + + ++++A N Sbjct: 292 AMGFSEDYIVEALRSDENNEVKEAYN 317 >2QNJ-A nrPDB Length = 328 Score = 277 bits (709), Expect = 5e-75, Method: Composition-based stats. Identities = 96/341 (28%), Positives = 157/341 (46%), Gaps = 29/341 (8%) Query: 55 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP-------KARREVEL 107 + I +Y++ + +G G KV + T + A+K++ K REV + Sbjct: 6 DEQPHIGNYRLL-KTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRI 64 Query: 108 HWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIM 167 + P+IV++ +V E K L ++ME GGE+F + G E+EA Sbjct: 65 M-KILNHPNIVKLFEVIET----EKTLYLIMEYASGGEVFDYLVAHG--RMKEKEARSKF 117 Query: 168 KSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTP 227 + I A+QY H I HRD+K ENLL + + +K+ DFGF+ E T L T C +P Sbjct: 118 RQIVSAVQYCHQKRIVHRDLKAENLLLDA---DMNIKIADFGFSNEFTVGGKLDTFCGSP 174 Query: 228 YYVAPEVLGPEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286 Y APE+ +KYD D+WSLGVI+Y L+ G PF + ++ R+ G+Y Sbjct: 175 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQN----LKELRERVLRGKYRI 230 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDK 346 P +S + + L++ L P +R T+ + M WI + + L Sbjct: 231 PF----YMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISD 286 Query: 347 ERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRR 387 ++ D+ M + ++ ++K +I LLL R+ Sbjct: 287 QKRIDIMVGMGYSQEEIQESLSKMKYDEITATY--LLLGRK 325 >2Y7J-A nrPDB Length = 365 Score = 277 bits (708), Expect = 7e-75, Method: Composition-based stats. Identities = 91/280 (32%), Positives = 148/280 (52%), Gaps = 32/280 (11%) Query: 67 SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK-------------ARREVELHWRASQ 113 V+G G++ V + ++ T +FA+K+++ + RRE + + + Sbjct: 99 KDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAG 158 Query: 114 CPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEA 173 PHI+ ++D YE+ + +V + + GELF + ++ A +E+E IM+S+ EA Sbjct: 159 HPHIITLIDSYESS----SFMFLVFDLMRKGELFDYLTEK--VALSEKETRSIMRSLLEA 212 Query: 174 IQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPE 233 + +LH+ NI HRD+KPEN+L N ++L+DFGF+ L C TP Y+APE Sbjct: 213 VSFLHANNIVHRDLKPENILLDD---NMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPE 269 Query: 234 VLGPE------KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 +L Y K D+W+ GVI++ LL G PPF+ + M I GQY+F Sbjct: 270 ILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQIL----MLRMIMEGQYQFS 325 Query: 288 NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 +PEW + S VK LI LL+ +P R+T + + HP+ + Sbjct: 326 SPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFER 365 >3MN3-A nrPDB Length = 271 Score = 276 bits (705), Expect = 2e-74, Method: Composition-based stats. Identities = 89/278 (32%), Positives = 135/278 (48%), Gaps = 29/278 (10%) Query: 58 AIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC--------PKARREVELHW 109 A I +Y++ + LG G GKV ++ T +K ALK++ + RE+ + Sbjct: 1 AHIGNYQIV-KTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREIS-YL 58 Query: 110 RASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 169 R + PHI+++ DV ++ + +++V+E G ELF I R +E+EA + Sbjct: 59 RLLRHPHIIKLYDVIKS----KDEIIMVIEYA-GNELFDYIVQR--DKMSEQEARRFFQQ 111 Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYY 229 I A++Y H I HRD+KPENLL + +K+ DFG + T N L T C +P Y Sbjct: 112 IISAVEYCHRHKIVHRDLKPENLLLDE---HLNVKIADFGLSNIMTDGNFLKTSCGSPNY 168 Query: 230 VAPEVLGPEKY-DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN 288 APEV+ + Y D+WS GVI+Y++LC PF P + I G Y P Sbjct: 169 AAPEVISGKLYAGPEVDVWSCGVILYVMLCRRLPFDDES----IPVLFKNISNGVYTLP- 223 Query: 289 PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIM 326 +S LI+ +L P R++I E M W Sbjct: 224 ---KFLSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFK 258 >4CZT-A nrPDB Length = 464 Score = 274 bits (700), Expect = 7e-74, Method: Composition-based stats. Identities = 88/303 (29%), Positives = 142/303 (46%), Gaps = 31/303 (10%) Query: 64 KVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP--------KARREVELHWRASQCP 115 + LG G KV N + A+K++ + +RE+ + + P Sbjct: 13 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTM-KLIKHP 71 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 +++R+ +V A + + V+E + GGELF +I G E EA + + + A+ Sbjct: 72 NVIRMFEV----MASKTKIYFVLEFVTGGELFDKISSNG--RLKEDEARKYFQQLINAVD 125 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFA---KETTSHNSLTTPCYTPYYVAP 232 Y HS + HRD+KPENLL + N LK++DFG + ++ L T C TP YVAP Sbjct: 126 YCHSRGVYHRDLKPENLLLDA---NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAP 182 Query: 233 EVLGPEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW 291 EV+ + YD D+WS GVI+++L+ GY PF ++ ++ + EF P W Sbjct: 183 EVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA------EFTCPPW 236 Query: 292 SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWED 351 S K LI+ +L P R+T E + + W + K P+ L + ++D Sbjct: 237 --FSASAKKLIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVS-LDDVDAIFDD 293 Query: 352 VKE 354 E Sbjct: 294 SGE 296 >3IS5-A nrPDB Length = 285 Score = 273 bits (699), Expect = 8e-74, Method: Composition-based stats. Identities = 80/279 (28%), Positives = 136/279 (48%), Gaps = 17/279 (6%) Query: 57 NAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD----CPKARREVELH-WRA 111 IDD + + LG G G V + + + + +K + P + E E+ ++ Sbjct: 17 QGTIDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLKS 76 Query: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDR--GDQAFTEREASEIMKS 169 P+I++I +V+E+ + + IVME +GGEL RI +A +E +E+MK Sbjct: 77 LDHPNIIKIFEVFEDYHN----MYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQ 132 Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYY 229 + A+ Y HS ++ H+D+KPEN+L+ P++ +K+ DFG A+ S T T Y Sbjct: 133 MMNALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALY 192 Query: 230 VAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNP 289 +APEV CD+WS GV+MY LL G PF + K + Y Sbjct: 193 MAPEVF-KRDVTFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQ--KATYKEPNYAV--- 246 Query: 290 EWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328 E ++ + L++ +L +P +R + + ++H W Q+ Sbjct: 247 ECRPLTPQAVDLLKQMLTKDPERRPSAAQVLHHEWFKQA 285 >4PDS-A nrPDB Length = 347 Score = 273 bits (699), Expect = 8e-74, Method: Composition-based stats. Identities = 89/298 (29%), Positives = 145/298 (48%), Gaps = 31/298 (10%) Query: 48 VKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKA------ 101 S + K I D+ + +V+G G V + + T + F++K++ Sbjct: 17 TASSMVANKTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGV 76 Query: 102 RREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTER 161 RE+E+ + P IVR+ YE+ + +VME + GG+L + G A E Sbjct: 77 TRELEVLQKL-NHPRIVRLKGFYEDT----ESYYMVMEFVSGGDLMDFVAAHG--AVGED 129 Query: 162 EASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT 221 EI + I AI+Y+HS+ I+HRD+KP+N+L P ++K+T FG AK + + + Sbjct: 130 AGREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDP-VLVKITAFGLAKVQGNGSFMK 188 Query: 222 TPCYTPYYVAPEVLGPE-------------KYDKSCDMWSLGVIMYILLCGYPPFYSNHG 268 T C T YVAPEV+ + +Y DMWS+G ++Y++L G+ PF Sbjct: 189 TFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSG--- 245 Query: 269 LAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIM 326 + + +I G Y + +SEE + I +LL+ +P R T + +NHPWI Sbjct: 246 -STQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWIK 302 >5KZ7-A nrPDB Length = 346 Score = 273 bits (698), Expect = 1e-73, Method: Composition-based stats. Identities = 89/286 (31%), Positives = 141/286 (49%), Gaps = 27/286 (9%) Query: 48 VKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP-------K 100 + S + I +Y++ + +G G KV + T ++ A+K++ K Sbjct: 20 LNSATSADEQPHIGNYRLL-KTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQK 78 Query: 101 ARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTE 160 REV + + P+IV++ +V E K L +VME GGE+F + G E Sbjct: 79 LFREVRIM-KVLNHPNIVKLFEVIET----EKTLYLVMEYASGGEVFDYLVAHG--RMKE 131 Query: 161 REASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL 220 +EA + I A+QY H I HRD+K ENLL + + +K+ DFGF+ E T N L Sbjct: 132 KEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDA---DMNIKIADFGFSNEFTFGNKL 188 Query: 221 TTPCYTPYYVAPEVLGPEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRI 279 T C +P Y APE+ +KYD D+WSLGVI+Y L+ G PF + ++ R+ Sbjct: 189 DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQN----LKELRERV 244 Query: 280 RMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 G+Y P +S + + L++ L P++R T+ + M W+ Sbjct: 245 LRGKYRIPF----YMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 286 >4UZD-A nrPDB Length = 287 Score = 271 bits (694), Expect = 4e-73, Method: Composition-based stats. Identities = 86/292 (29%), Positives = 142/292 (48%), Gaps = 28/292 (9%) Query: 54 IKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP--------KARREV 105 +K+ ++D+++ + LG G G V K+++ ALK+L + RREV Sbjct: 1 MKRQWALEDFEI-GRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREV 59 Query: 106 ELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASE 165 E+ + P+I+R+ + + + +++E G ++ +Q F E+ + Sbjct: 60 EIQS-HLRHPNILRLYGYFHDA----TRVYLILEYAPLGTVYRELQKLS--KFDEQRTAT 112 Query: 166 IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY 225 + + A+ Y HS + HRD+KPENLL S LK+ DFG++ S TT C Sbjct: 113 YITELANALSYCHSKRVIHRDIKPENLLLGSA---GELKIADFGWSVHAPSSRR-TTLCG 168 Query: 226 TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE 285 T Y+ PE++ +D+ D+WSLGV+ Y L G PPF +N RI ++ Sbjct: 169 TLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEAN----TYQETYKRISRVEFT 224 Query: 286 FPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLH 337 FP+ V+E + LI LLK P+QR + E + HPWI ++ P + Sbjct: 225 FPD----FVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQN 272 >4CQG-A nrPDB Length = 331 Score = 270 bits (691), Expect = 6e-73, Method: Composition-based stats. Identities = 89/321 (27%), Positives = 157/321 (48%), Gaps = 34/321 (10%) Query: 62 DYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ------DCPKARREVELHWRASQCP 115 Y + +G G KV + T E A+K++ D P+ + E++ ++ + Sbjct: 9 KYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEID-ALKSLRHQ 67 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 HI ++ V E + + +V+E GGELF I + +E E + + I A+ Sbjct: 68 HICQLYHVLET----KNKIFMVLEYCPGGELFDYIISQ--DRLSEEETRVVFRQILSAVA 121 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL--TTPCYTPYYVAPE 233 Y+HS AHRD+KPENLL+ N LKL DFG + + C + Y APE Sbjct: 122 YVHSQGYAHRDLKPENLLFDE---NHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPE 178 Query: 234 VLGPEKY-DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWS 292 ++ + Y D+WS+G+++Y+L+CG+ PF ++ +A + +I G+YE P W Sbjct: 179 LIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMA----LYKKIMRGKYEVPK--W- 231 Query: 293 EVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVP-----QTPLH--TSRVLKED 345 +S +L++ +L+ +P +R+++ +NHPW+MQ P +TPL + E Sbjct: 232 -LSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQDYSCPVEWQSKTPLTHLDEDCVTEL 290 Query: 346 KERWEDVKEEMTSALATMRVD 366 ++ M +++ + D Sbjct: 291 SVHHRSSRQTMEDLISSWQYD 311 >6ED6-A nrPDB Length = 415 Score = 270 bits (691), Expect = 8e-73, Method: Composition-based stats. Identities = 90/348 (25%), Positives = 157/348 (45%), Gaps = 53/348 (15%) Query: 50 SGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARR------ 103 GLQ+K +DY V +V+G G G+V + +K +Q+ +A+K+L +R Sbjct: 81 RGLQMKA----EDYDVV-KVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFF 135 Query: 104 --EVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTER 161 E ++ + P +V++ +++ + L +VME + GG+L + + + E+ Sbjct: 136 WEERDIMA-FANSPWVVQLFYAFQD----DRYLYMVMEYMPGGDLVNLM---SNYDVPEK 187 Query: 162 EASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL- 220 A + A+ +HS+ + HRDVKP+N+L + LKL DFG + + Sbjct: 188 WAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLD---KHGHLKLADFGTCMKMDETGMVH 244 Query: 221 -TTPCYTPYYVAPEVLGPEK----YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGM 275 T TP Y++PEVL + Y + CD WS+GV +Y +L G PFY++ + G Sbjct: 245 CDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLV----GT 300 Query: 276 KTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQ--RMTITEFMNHPWIMQSTKVPQ 333 ++I + PE +E+S+ K LI L + R + E HP+ Sbjct: 301 YSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFF-------- 352 Query: 334 TPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNP 381 K D+ W++++E + + D + IED Sbjct: 353 ---------KNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGD 391 >1KOB-A nrPDB Length = 387 Score = 269 bits (688), Expect = 1e-72, Method: Composition-based stats. Identities = 86/312 (27%), Positives = 156/312 (50%), Gaps = 20/312 (6%) Query: 48 VKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-----DCPKAR 102 V +++K+ ++ D Y + + LG G G V + K T F K + D + Sbjct: 38 VPQPVEVKQGSVYDYYDILEE-LGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVK 96 Query: 103 REVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTERE 162 E+ + + P ++ + D +E+ Y +++++E L GGELF RI D +E E Sbjct: 97 NEISIMNQL-HHPKLINLHDAFEDKYE----MVLILEFLSGGELFDRIAAE-DYKMSEAE 150 Query: 163 ASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTT 222 M+ E ++++H +I H D+KPEN++ +K+ ++ +K+ DFG A + + Sbjct: 151 VINYMRQACEGLKHMHEHSIVHLDIKPENIMCETKKASS-VKIIDFGLATKLNPDEIVKV 209 Query: 223 PCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMG 282 T + APE++ E DMW++GV+ Y+LL G PF L ++ Sbjct: 210 TTATAEFAAPEIVDREPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQ----NVKRC 265 Query: 283 QYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTS--- 339 +EF +S VS E K I+NLL+ EP +R+T+ + + HPW+ + + +S Sbjct: 266 DWEFDEDAFSSVSPEAKDFIKNLLQKEPRKRLTVHDALEHPWLKGDHSNLTSRIPSSRYN 325 Query: 340 RVLKEDKERWED 351 ++ ++ KE++ D Sbjct: 326 KIRQKIKEKYAD 337 >3D2K-A nrPDB Length = 272 Score = 268 bits (686), Expect = 3e-72, Method: Composition-based stats. Identities = 85/287 (29%), Positives = 141/287 (49%), Gaps = 28/287 (9%) Query: 55 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP--------KARREVE 106 K+ ++D+ + + LG G G V ++++ ALK+L + RREVE Sbjct: 6 KRQWTLEDFDI-GRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVE 64 Query: 107 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 + + P+I+R+ + + + +++E G ++ +Q F E+ + Sbjct: 65 IQS-HLRHPNILRLYGYFHDA----TRVYLILEYAPLGTVYRELQKLS--RFDEQRTATY 117 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 226 + + A+ Y HS + HRD+KPENLL S N LK+ DFG++ S TT C T Sbjct: 118 ITELANALSYCHSKRVIHRDIKPENLLLGS---NGELKIADFGWSVHAPSSRR-TTLCGT 173 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286 Y+ PE++ +D+ D+WSLGV+ Y L G PPF ++ RI ++ F Sbjct: 174 LDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAH----TYQETYRRISRVEFTF 229 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ 333 P+ V+E + LI LLK +QR+T+ E + HPWI ++ P Sbjct: 230 PD----FVTEGARDLISRLLKHNASQRLTLAEVLEHPWIKANSSKPS 272 >4D2V-A nrPDB Length = 356 Score = 268 bits (685), Expect = 3e-72, Method: Composition-based stats. Identities = 86/294 (29%), Positives = 142/294 (48%), Gaps = 27/294 (9%) Query: 48 VKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ------DCPKA 101 V G +K + Y + +G G KV + T E A+K++ D P+ Sbjct: 15 VPRGSHMKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRI 74 Query: 102 RREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTER 161 + E+E + + HI ++ V E + +V+E GGELF I + +E Sbjct: 75 KTEIE-ALKNLRHQHICQLYHVLETA----NKIFMVLEYCPGGELFDYIISQ--DRLSEE 127 Query: 162 EASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL- 220 E + + I A+ Y+HS AHRD+KPENLL+ LKL DFG + + Sbjct: 128 ETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHK---LKLIDFGLCAKPKGNKDYH 184 Query: 221 -TTPCYTPYYVAPEVLGPEKY-DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTR 278 C Y APE++ + Y D+WS+G+++Y+L+CG+ PF + A+ + Sbjct: 185 LQACCGALAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALV----AK 240 Query: 279 IRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVP 332 I G+Y+ P W +S +L++ +L+ +P +R+++ +NHPWIMQ P Sbjct: 241 IMRGKYDVPK--W--LSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYP 290 >3UTO-A nrPDB Length = 573 Score = 268 bits (685), Expect = 4e-72, Method: Composition-based stats. Identities = 93/356 (26%), Positives = 159/356 (44%), Gaps = 37/356 (10%) Query: 4 NSQGQSPPVPFPAP-------APPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSG----- 51 N GQS P AP + + + + Sbjct: 86 NKHGQSKPCEPTAPVLIPGDERKRRRGYDVDEQGKIVRGKGTVSSNYDNYVFDIWKQYYP 145 Query: 52 --LQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-----QDCPKARRE 104 ++IK + ++D Y + + LG G G V ++ + T FA K + D R+E Sbjct: 146 QPVEIKHDHVLDHYDIHEE-LGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKE 204 Query: 105 VELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREAS 164 ++ + P +V + D +E+ ++++ E + GGELF ++ D ++ +E EA Sbjct: 205 IQTMS-VLRHPTLVNLHDAFED----DNEMVMIYEFMSGGELFEKVADEHNK-MSEDEAV 258 Query: 165 EIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPC 224 E M+ + + + ++H N H D+KPEN+++T+KR N LKL DFG S+ Sbjct: 259 EYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSN-ELKLIDFGLTAHLDPKQSVKVTT 317 Query: 225 YTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQY 284 T + APEV + DMWS+GV+ YILL G PF + ++ + Sbjct: 318 GTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGEN----DDETLRNVKSCDW 373 Query: 285 EFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIM------QSTKVPQT 334 + +S +SE+ K IR LL +P RMTI + + HPW+ + +++P + Sbjct: 374 NMDDSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAPGRDSQIPSS 429 >6E9W-A nrPDB Length = 443 Score = 267 bits (682), Expect = 8e-72, Method: Composition-based stats. Identities = 82/353 (23%), Positives = 154/353 (43%), Gaps = 49/353 (13%) Query: 41 QQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK 100 ++ +DY+V +V+G G G+V + +K T++ +A+K+L Sbjct: 82 NFLSRYKDTINKIRDLRMKAEDYEVV-KVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEM 140 Query: 101 ARR--------EVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQD 152 +R E ++ + P +V++ +++ + L +VME + GG+L + + Sbjct: 141 IKRSDSAFFWEERDIMA-FANSPWVVQLFYAFQD----DRYLYMVMEYMPGGDLVNLM-- 193 Query: 153 RGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK 212 + E+ A + A+ +HS+ HRDVKP+N+L + LKL DFG Sbjct: 194 -SNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLD---KSGHLKLADFGTCM 249 Query: 213 ETTSHNSLT--TPCYTPYYVAPEVLGPEK----YDKSCDMWSLGVIMYILLCGYPPFYSN 266 + + T TP Y++PEVL + Y + CD WS+GV +Y +L G PFY++ Sbjct: 250 KMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYAD 309 Query: 267 HGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQ--RMTITEFMNHPW 324 + G ++I + P+ +++S+E K LI L + R + E H + Sbjct: 310 SLV----GTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLF 365 Query: 325 IMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIED 377 K D+ WE +++ + + + D + +E+ Sbjct: 366 F-----------------KNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEE 401 >4D28-A nrPDB Length = 446 Score = 266 bits (680), Expect = 1e-71, Method: Composition-based stats. Identities = 95/311 (30%), Positives = 150/311 (48%), Gaps = 29/311 (9%) Query: 53 QIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD--------CPKARRE 104 KK + Y+V + +G G KV N T + A+K++ + +RE Sbjct: 1 MTKKMRRVGKYEV-GRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKRE 59 Query: 105 VELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREAS 164 + + + + P+IVR+ +V A + + IV+E + GGELF RI +G E E+ Sbjct: 60 ISIM-KIVRHPNIVRLYEVL----ASKSKIYIVLEFVTGGELFDRIVHKG--RLKEDESR 112 Query: 165 EIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSH-NSLTTP 223 + + + +A+ + HS + HRD+KPENLL + N LK++DFG + L Sbjct: 113 KYFQQLVDAVAHCHSKGVYHRDLKPENLLLDT---NGNLKVSDFGLSALPQEGVELLNDT 169 Query: 224 CYTPYYVAPEVLGPEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMG 282 C TP YVAPEVL + YD + D+WS GVI++++L GY PF PG+ +I Sbjct: 170 CGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETD----LPGLYRKINAA 225 Query: 283 QYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVL 342 EF P W S EVK LI +L P R+ I PW ++ + L Sbjct: 226 --EFDCPPW--FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRKNYVPIRAREEEEVNL 281 Query: 343 KEDKERWEDVK 353 + + ++ ++ Sbjct: 282 DDIRAVFDGIE 292 >5KCV-A nrPDB Length = 460 Score = 266 bits (679), Expect = 2e-71, Method: Composition-based stats. Identities = 88/286 (30%), Positives = 137/286 (47%), Gaps = 32/286 (11%) Query: 55 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD-CPKARREVE------L 107 K +++++ ++LG G GKV+ + K T +A+K+L+ A+ EV Sbjct: 156 KHRVTMNEFEYL-KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENR 214 Query: 108 HWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIM 167 + S+ P + + ++ L VME +GGELF + ++ F+E A Sbjct: 215 VLQNSRHPFLTALKYSFQT----HDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYG 268 Query: 168 KSIGEAIQYLHS-INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCY 225 I A+ YLHS N+ +RD+K ENL+ + +K+TDFG KE ++ T C Sbjct: 269 AEIVSALDYLHSEKNVVYRDLKLENLMLD---KDGHIKITDFGLCKEGIKDGATMKTFCG 325 Query: 226 TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE 285 TP Y+APEVL Y ++ D W LGV+MY ++CG PFY+ + I M + Sbjct: 326 TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQD----HEKLFELILMEEIR 381 Query: 286 FPNPEWSEVSEEVKMLIRNLLKTEPTQRMT-----ITEFMNHPWIM 326 FP + E K L+ LLK +P QR+ E M H + Sbjct: 382 FPR----TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 423 >2JDO-A nrPDB Length = 342 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 88/282 (31%), Positives = 140/282 (49%), Gaps = 31/282 (10%) Query: 58 AIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-QDCPKARREVE------LHWR 110 ++D+ ++LG G GKV+ + K T +A+K+L ++ A+ EV + Sbjct: 7 VTMNDFDYL-KLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ 65 Query: 111 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 ++ P + + ++ L VME +GGELF + ++ FTE A I Sbjct: 66 NTRHPFLTALKYAFQT----HDRLCFVMEYANGGELFFHLSR--ERVFTEERARFYGAEI 119 Query: 171 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYY 229 A++YLHS ++ +RD+K ENL+ + +K+TDFG KE + ++ T C TP Y Sbjct: 120 VSALEYLHSRDVVYRDIKLENLMLD---KDGHIKITDFGLCKEGISDGATMKTFCGTPEY 176 Query: 230 VAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNP 289 +APEVL Y ++ D W LGV+MY ++CG PFY+ + I M + FP Sbjct: 177 LAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQD----HERLFELILMEEIRFPR- 231 Query: 290 EWSEVSEEVKMLIRNLLKTEPTQRMT-----ITEFMNHPWIM 326 +S E K L+ LLK +P QR+ E M H + + Sbjct: 232 ---TLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFL 270 >3LM0-A nrPDB Length = 327 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 78/287 (27%), Positives = 135/287 (47%), Gaps = 16/287 (5%) Query: 49 KSGLQIKKNAIIDDYKVT-SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK------- 100 L + +++ + S+ LG G V Q +K T +++A K L+ + Sbjct: 15 TENLYFQSMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAE 74 Query: 101 ARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTE 160 E+ + A CP ++ + +VYEN +++++E GGE+FS + +E Sbjct: 75 ILHEIAVLELAKSCPRVINLHEVYENTSE----IILILEYAAGGEIFSLCLPELAEMVSE 130 Query: 161 REASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL 220 + ++K I E + YLH NI H D+KP+N+L +S P +K+ DFG +++ L Sbjct: 131 NDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACEL 190 Query: 221 TTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIR 280 TP Y+APE+L + + DMW++G+I Y+LL PF I Sbjct: 191 REIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDN----QETYLNIS 246 Query: 281 MGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 ++ +S VS+ I++LL P +R T ++H W+ Q Sbjct: 247 QVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQ 293 >1KOA-A nrPDB Length = 491 Score = 264 bits (676), Expect = 3e-71, Method: Composition-based stats. Identities = 86/294 (29%), Positives = 148/294 (50%), Gaps = 23/294 (7%) Query: 52 LQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-----QDCPKARREVE 106 ++IK + ++D Y + + LG G G V ++ + T FA K + D R+E++ Sbjct: 42 VEIKHDHVLDHYDIHEE-LGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQ 100 Query: 107 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 + P +V + D +E+ ++++ E + GGELF ++ D ++ +E EA E Sbjct: 101 TMS-VLRHPTLVNLHDAFED----DNEMVMIYEFMSGGELFEKVADEHNK-MSEDEAVEY 154 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 226 M+ + + + ++H N H D+KPEN+++T+KR N LKL DFG S+ T Sbjct: 155 MRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSN-ELKLIDFGLTAHLDPKQSVKVTTGT 213 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286 + APEV + DMWS+GV+ YILL G PF + ++ + Sbjct: 214 AEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGEN----DDETLRNVKSCDWNM 269 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIM------QSTKVPQT 334 + +S +SE+ K IR LL +P RMTI + + HPW+ + +++P + Sbjct: 270 DDSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAPGRDSQIPSS 323 >3COM-A nrPDB Length = 314 Score = 264 bits (674), Expect = 7e-71, Method: Composition-based stats. Identities = 80/300 (26%), Positives = 134/300 (44%), Gaps = 19/300 (6%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML---QDCPKARREVELHWRASQCPHI 117 + + V + LG G G V + +K T + A+K + D + +E+ + + PH+ Sbjct: 29 EVFDVLEK-LGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQC-DSPHV 86 Query: 118 VRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL 177 V+ Y Y L IVME G + I+ R ++ TE E + I++S + ++YL Sbjct: 87 VK----YYGSYFKNTDLWIVMEYCGAGSVSDIIRLR-NKTLTEDEIATILQSTLKGLEYL 141 Query: 178 HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN-SLTTPCYTPYYVAPEVLG 236 H + HRD+K N+L ++ KL DFG A + T T TP+++APEV+ Sbjct: 142 HFMRKIHRDIKAGNILLNTE---GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ 198 Query: 237 PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSE 296 Y+ D+WSLG+ + G PP+ H + + T F PE S+ Sbjct: 199 EIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTN---PPPTFRKPEL--WSD 253 Query: 297 EVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEM 356 ++ L P QR T T+ + HP++ + V + + +R E + E Sbjct: 254 NFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREE 313 >4JXF-A nrPDB Length = 266 Score = 263 bits (673), Expect = 8e-71, Method: Composition-based stats. Identities = 82/279 (29%), Positives = 139/279 (49%), Gaps = 27/279 (9%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD--------CPKARREVELHWRA 111 I+D+KV +LG G V + + T + A+KM+ + + EV++H + Sbjct: 6 IEDFKV-GNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQL 64 Query: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 + P I+ + + +E+ + +V+E GE+ +++R + F+E EA M I Sbjct: 65 -KHPSILELYNYFEDS----NYVYLVLEMCHNGEMNRYLKNR-VKPFSENEARHFMHQII 118 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT-SHNSLTTPCYTPYYV 230 + YLHS I HRD+ NLL T N +K+ DFG A + H T C TP Y+ Sbjct: 119 TGMLYLHSHGILHRDLTLSNLLLT---RNMNIKIADFGLATQLKMPHEKHYTLCGTPNYI 175 Query: 231 APEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE 290 +PE+ + D+WSLG + Y LL G PPF ++ ++ + YE P Sbjct: 176 SPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTD----TVKNTLNKVVLADYEMP--- 228 Query: 291 WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQST 329 S +S E K LI LL+ P R++++ ++HP++ +++ Sbjct: 229 -SFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNS 266 >4YNZ-A nrPDB Length = 342 Score = 263 bits (672), Expect = 1e-70, Method: Composition-based stats. Identities = 83/288 (28%), Positives = 144/288 (50%), Gaps = 26/288 (9%) Query: 64 KVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP-------KARREVELHWRASQCPH 116 + LG G G V + T +K A+K++ K RE+ + + + PH Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAI-LKLIEHPH 70 Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 ++++ DVYEN +K L +V+E + GGELF + +G T +EA + + I A+ + Sbjct: 71 VLKLHDVYEN----KKYLYLVLEHVSGGELFDYLVKKG--RLTPKEARKFFRQIISALDF 124 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 236 HS +I HRD+KPENLL + +++ DFG A + L T C +P+Y PEV+ Sbjct: 125 CHSHSICHRDLKPENLLLDERNN---IRIADFGMASLQVGDSLLETSCGSPHYACPEVIR 181 Query: 237 PEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 295 EKYD + D+WS GVI++ LL G PF ++ + +++ G + P + Sbjct: 182 GEKYDGRKADVWSCGVILFALLVGALPFDDDN----LRQLLEKVKRGVFHMP----HFIP 233 Query: 296 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLK 343 + + L+R +++ + +R+T+ H W + P+ R ++ Sbjct: 234 PDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQ 281 >5N23-A nrPDB Length = 352 Score = 262 bits (670), Expect = 2e-70, Method: Composition-based stats. Identities = 88/286 (30%), Positives = 146/286 (51%), Gaps = 33/286 (11%) Query: 54 IKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR--------REV 105 + A +D ++ + LG G G+V+ + +K T +A+K+L + E Sbjct: 35 AQNTAHLDQFERI-RTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEK 93 Query: 106 ELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASE 165 + +A P +V++ E + L +V+E GGE+FS ++ G F+E A Sbjct: 94 RIQ-QAVNFPFLVKL----EFSFKDNSNLYMVLEYAPGGEMFSHLRRIG--RFSEPHARF 146 Query: 166 IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY 225 I +YLHS+++ +RD+KPENLL + +K+ DFGFAK T C Sbjct: 147 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQ---GYIKVADFGFAKRVKGRTPW-TLCG 202 Query: 226 TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE 285 TP Y+APE++ + Y+K+ D W+LGV++Y + GYPPF+++ + I +I G+ Sbjct: 203 TPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI----YEKIVSGKVR 258 Query: 286 FPNPEWSEVSEEVKMLIRNLLKTEPTQRM-----TITEFMNHPWIM 326 FP S S ++K L+RNLL+ + T+R + + NH W Sbjct: 259 FP----SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 300 >1FOT-A nrPDB Length = 318 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 84/280 (30%), Positives = 142/280 (50%), Gaps = 32/280 (11%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR-------REVELHWRAS 112 + D+++ + LG G G+V I ++ +A+K+L+ R + L Sbjct: 5 LQDFQIL-RTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIV 63 Query: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 P I+R+ +++ + + ++M+ ++GGELFS ++ Q F A + Sbjct: 64 THPFIIRMWGTFQDA----QQIFMIMDYIEGGELFSLLRK--SQRFPNPVAKFYAAEVCL 117 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAP 232 A++YLHS +I +RD+KPEN+L N +K+TDFGFAK T C TP Y+AP Sbjct: 118 ALEYLHSKDIIYRDLKPENILLD---KNGHIKITDFGFAKYVPDVTY--TLCGTPDYIAP 172 Query: 233 EVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWS 292 EV+ + Y+KS D WS G+++Y +L GY PFY ++ + +I + FP Sbjct: 173 EVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKT----YEKILNAELRFP----P 224 Query: 293 EVSEEVKMLIRNLLKTEPTQRM-----TITEFMNHPWIMQ 327 +E+VK L+ L+ + +QR+ + NHPW + Sbjct: 225 FFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKE 264 >3MV5-A nrPDB Length = 342 Score = 261 bits (668), Expect = 3e-70, Method: Composition-based stats. Identities = 87/287 (30%), Positives = 137/287 (47%), Gaps = 32/287 (11%) Query: 54 IKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD-CPKARREVE------ 106 + +++++ ++LG G GKV+ + K T +A+K+L+ A+ EV Sbjct: 3 MDPRVTMNEFEYL-KLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTEN 61 Query: 107 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 + S+ P + + ++ L VME +GGELF + ++ F+E A Sbjct: 62 RVLQNSRHPFLTALKYSFQT----HDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFY 115 Query: 167 MKSIGEAIQYLHS-INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPC 224 I A+ YLHS N+ +RD+K ENL+ + +K+TDFG KE ++ T C Sbjct: 116 GAEIVSALDYLHSEKNVVYRDLKLENLMLD---KDGHIKITDFGLCKEGIKDGATMKTFC 172 Query: 225 YTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQY 284 TP Y+APEVL Y ++ D W LGV+MY ++CG PFY+ + I M + Sbjct: 173 GTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQD----HEKLFELILMEEI 228 Query: 285 EFPNPEWSEVSEEVKMLIRNLLKTEPTQRMT-----ITEFMNHPWIM 326 FP + E K L+ LLK +P QR+ E M H + Sbjct: 229 RFPR----TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFA 271 >5X3F-B nrPDB Length = 393 Score = 260 bits (665), Expect = 7e-70, Method: Composition-based stats. Identities = 94/337 (27%), Positives = 161/337 (47%), Gaps = 40/337 (11%) Query: 55 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR--------REVE 106 + A +D + + LG G G+V+ + +K + +A+K+L + E Sbjct: 78 QNTAQLDQFDRI-KTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKR 136 Query: 107 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 + +A P +V++ E + L +VME + GGE+FS ++ G F+E A Sbjct: 137 I-LQAVNFPFLVKL----EFSFKDNSNLYMVMEYVAGGEMFSHLRRIG--RFSEPHARFY 189 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 226 I +YLHS+++ +RD+KPENLL + +++TDFGFAK T C T Sbjct: 190 AAQIVLTFEYLHSLDLIYRDLKPENLLIDQQ---GYIQVTDFGFAKRVKGRTW--TLCGT 244 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286 P Y+APE++ + Y+K+ D W+LGV++Y + GYPPF+++ + I +I G+ F Sbjct: 245 PEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI----YEKIVSGKVRF 300 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRM-----TITEFMNHPWIMQST------KVPQTP 335 P S S ++K L+RNLL+ + T+R + + NH W + + + P Sbjct: 301 P----SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAP 356 Query: 336 LHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKI 372 D ++D +EE + E + Sbjct: 357 FIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF 393 >4WB7-A nrPDB Length = 405 Score = 259 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 89/286 (31%), Positives = 148/286 (51%), Gaps = 34/286 (11%) Query: 54 IKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR--------REV 105 + A +D ++ + LG G G+V+ + +K T +A+K+L + E Sbjct: 89 AQNTAHLDQFERI-KTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEK 147 Query: 106 ELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASE 165 + +A P +V++ E + L +VME + GGE+FS ++ G F+E A Sbjct: 148 RI-LQAVNFPFLVKL----EFSFKDNSNLYMVMEYVPGGEMFSHLRRIG--RFSEPHARF 200 Query: 166 IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY 225 I +YLHS+++ +RD+KPENLL + +++TDFGFAK T C Sbjct: 201 YAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQ---GYIQVTDFGFAKRVKGRTW--TLCG 255 Query: 226 TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE 285 TP Y+APE++ + Y+K+ D W+LGV++Y + GYPPF+++ + I +I G+ Sbjct: 256 TPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI----YEKIVSGKVR 311 Query: 286 FPNPEWSEVSEEVKMLIRNLLKTEPTQRM-----TITEFMNHPWIM 326 FP S S ++K L+RNLL+ + T+R + + NH W Sbjct: 312 FP----SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFA 353 >4FIE-A nrPDB Length = 423 Score = 258 bits (659), Expect = 4e-69, Method: Composition-based stats. Identities = 80/324 (24%), Positives = 145/324 (44%), Gaps = 30/324 (9%) Query: 18 APPPQPPTPALPHPPAQPPPP-PPQQFPQFHVKSGLQIKKNAIIDD-----YKVTSQVLG 71 +PPP P +PP P PQ+ PQ + ++D Y +G Sbjct: 101 SPPPPARARQENGMPEKPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIG 160 Query: 72 LGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELH----WRASQCPHIVRIVDVYENL 127 G G V + + + A+K + + RRE+ + R Q ++V + + Y Sbjct: 161 EGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY--- 217 Query: 128 YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDV 187 L +VME L+GG L + E + + + ++ +A+ LH+ + HRD+ Sbjct: 218 -LVGDELWVVMEFLEGGALTDIV---THTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDI 273 Query: 188 KPENLLYTSKRPNAILKLTDFGFAKET-TSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDM 246 K +++L T + +KL+DFGF + + TPY++APE++ Y D+ Sbjct: 274 KSDSILLTH---DGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDI 330 Query: 247 WSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN--PEWSEVSEEVKMLIRN 304 WSLG+++ ++ G PP+++ L ++M + P +VS +K + Sbjct: 331 WSLGIMVIEMVDGEPPYFNEPPL-------KAMKMIRDNLPPRLKNLHKVSPSLKGFLDR 383 Query: 305 LLKTEPTQRMTITEFMNHPWIMQS 328 LL +P QR T E + HP++ ++ Sbjct: 384 LLVRDPAQRATAAELLKHPFLAKA 407 >6FDY-U nrPDB Length = 276 Score = 257 bits (658), Expect = 4e-69, Method: Composition-based stats. Identities = 81/272 (29%), Positives = 138/272 (50%), Gaps = 21/272 (7%) Query: 62 DYKVTSQVLGLGINGKVLQIF-NKRTQEKFALKMLQD-------CPKARREVELHWRASQ 113 D + ++ LG G V + + K T+E A+K + E+E+ + + Sbjct: 11 DGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEI-LKGIR 69 Query: 114 CPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEA 173 PHIV++ D + ++ME GG+L I R + E+ A M+ + A Sbjct: 70 HPHIVQLKDF----QWDSDNIYLIMEFCAGGDLSRFIHTR--RILPEKVARVFMQQLASA 123 Query: 174 IQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPE 233 +Q+LH NI+H D+KP+N+L +S LKL DFGFA+ + + +P Y+APE Sbjct: 124 LQFLHERNISHLDLKPQNILLSSLEK-PHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPE 182 Query: 234 VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSE 293 ++ +YD D+WS+GVI+Y L G PPF S ++ +IR + P Sbjct: 183 MVCQRQYDARVDLWSMGVILYEALFGQPPFASRS----FSELEEKIRSNRV-IELPLRPL 237 Query: 294 VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 +S + + L++ LL+ +P++R++ +F HPW+ Sbjct: 238 LSRDCRDLLQRLLERDPSRRISFQDFFAHPWV 269 >4LG4-A nrPDB Length = 299 Score = 256 bits (654), Expect = 1e-68, Method: Composition-based stats. Identities = 76/293 (25%), Positives = 132/293 (45%), Gaps = 19/293 (6%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML---QDCPKARREVELHWRASQCPHI 117 + + V + LG G G V + +K + + A+K + D + +E+ + + P++ Sbjct: 11 EVFDVLEK-LGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQC-DSPYV 68 Query: 118 VRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL 177 V+ Y Y L IVME G + I+ R ++ E E + I+KS + ++YL Sbjct: 69 VK----YYGSYFKNTDLWIVMEYCGAGSVSDIIRLR-NKTLIEDEIATILKSTLKGLEYL 123 Query: 178 HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN-SLTTPCYTPYYVAPEVLG 236 H + HR++K N+L ++ KL DFG A + T T TP+++APEV+ Sbjct: 124 HFMRKIHRNIKAGNILLNTE---GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ 180 Query: 237 PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSE 296 Y+ D+WSLG+ + G PP+ H + + T F PE S+ Sbjct: 181 EIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTN---PPPTFRKPEL--WSD 235 Query: 297 EVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERW 349 + ++ L P QR T T+ + HP+I + V + ++ +R Sbjct: 236 DFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRH 288 >6FD3-A nrPDB Length = 300 Score = 255 bits (651), Expect = 3e-68, Method: Composition-based stats. Identities = 72/264 (27%), Positives = 131/264 (49%), Gaps = 20/264 (7%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELH----WRASQCPHIVRIVDV 123 + +G G +G V + T ++ A+K + + ++E+ ++ R ++ P+IV +D Sbjct: 28 EKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDS 87 Query: 124 YENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIA 183 Y L +VME L GG L + + E + + + + +A+ +LHS + Sbjct: 88 Y----LVGDELWVVMEYLAGGSLTDVVTE---TCMDEGQIAAVCRECLQALDFLHSNQVI 140 Query: 184 HRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS-LTTPCYTPYYVAPEVLGPEKYDK 242 HRD+K +N+L + +KLTDFGF + T S +T TPY++APEV+ + Y Sbjct: 141 HRDIKSDNILLG---MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGP 197 Query: 243 SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI 302 D+WSLG++ ++ G PP+ + + L + T G E NPE +S + + Sbjct: 198 KVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATN---GTPELQNPE--RLSAVFRDFL 252 Query: 303 RNLLKTEPTQRMTITEFMNHPWIM 326 L+ + +R + E + HP++ Sbjct: 253 NRCLEMDVDRRGSAKELLQHPFLK 276 >2HAK-A nrPDB Length = 328 Score = 254 bits (650), Expect = 3e-68, Method: Composition-based stats. Identities = 93/332 (28%), Positives = 151/332 (45%), Gaps = 27/332 (8%) Query: 55 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP-------KARREVEL 107 + I +Y++ + +G G KV + T + A+K++ K REV + Sbjct: 9 DEQPHIGNYRL-QKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRI 67 Query: 108 HWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIM 167 + P+IV++ +V E K L +VME GGE+F + G E+EA Sbjct: 68 M-KILNHPNIVKLFEVIET----EKTLYLVMEYASGGEVFDYLVAHG--RMKEKEARAKF 120 Query: 168 KSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTP 227 + I A+QY H I HRD+K ENLL + +K+ DFGF+ E T N L T C +P Sbjct: 121 RQIVSAVQYCHQKYIVHRDLKAENLLLD---GDMNIKIADFGFSNEFTVGNKLDTFCGSP 177 Query: 228 YYVAPEVLGPEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286 Y APE+ +KYD D+WSLGVI+Y L+ G PF + ++ R+ G+Y Sbjct: 178 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQN----LKELRERVLRGKYRI 233 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDK 346 P +S + + L++ LL P +R ++ + M W+ + + +T + Sbjct: 234 PF----YMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDFND 289 Query: 347 ERWEDVKEEMTSALATMRVDYEQIKIKKIEDA 378 + D+ M A + K ++ Sbjct: 290 TKRIDIMVTMGFARDEINDALINQKYDEVMAT 321 >3HDN-A nrPDB Length = 373 Score = 254 bits (650), Expect = 4e-68, Method: Composition-based stats. Identities = 85/271 (31%), Positives = 136/271 (50%), Gaps = 30/271 (11%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARR--------EVELHWRASQCPHIVR 119 +V+G G GKVL +K + +A+K+LQ ++ E + + + P +V Sbjct: 44 KVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVG 103 Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 + ++ L V++ ++GGELF +Q ++ F E A I A+ YLHS Sbjct: 104 LHFSFQTA----DKLYFVLDYINGGELFYHLQR--ERCFLEPRARFYAAEIASALGYLHS 157 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TPCYTPYYVAPEVLGPE 238 +NI +RD+KPEN+L S+ + LTDFG KE HNS T T C TP Y+APEVL + Sbjct: 158 LNIVYRDLKPENILLDSQ---GHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQ 214 Query: 239 KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEV 298 YD++ D W LG ++Y +L G PPFYS + + + + P ++ Sbjct: 215 PYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNK--------PLQLKPNITNSA 266 Query: 299 KMLIRNLLKTEPTQRMTIT----EFMNHPWI 325 + L+ LL+ + T+R+ E +H + Sbjct: 267 RHLLEGLLQKDRTKRLGAKDDFMEIKSHVFF 297 >5D7A-A nrPDB Length = 308 Score = 254 bits (649), Expect = 5e-68, Method: Composition-based stats. Identities = 68/299 (22%), Positives = 131/299 (43%), Gaps = 22/299 (7%) Query: 63 YKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ----DCPKARREVELHWRASQCPHIV 118 +++ +++G G G+V + + +T + A+K++ + + ++E+ + + S +I Sbjct: 19 FELV-ELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIA 77 Query: 119 RIVDVY--ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 + +N L +VME G + I++ E + I + I + + Sbjct: 78 TYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSH 137 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSH-NSLTTPCYTPYYVAPEVL 235 LH + HRD+K +N+L T NA +KL DFG + + T TPY++APEV+ Sbjct: 138 LHQHKVIHRDIKGQNVLLTE---NAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVI 194 Query: 236 GPEK-----YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE 290 ++ YD D+WSLG+ + G PP H M+ + + P + Sbjct: 195 ACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHP------MRALFLIPRNPAPRLK 248 Query: 291 WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERW 349 + S++ + I + L +QR + M HP+I Q + + K++ Sbjct: 249 SKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKR 307 >4QMW-A nrPDB Length = 310 Score = 254 bits (649), Expect = 5e-68, Method: Composition-based stats. Identities = 81/304 (26%), Positives = 138/304 (45%), Gaps = 27/304 (8%) Query: 37 PPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQV--LGLGINGKVLQIFNKRTQEKFALKM 94 P + V+SGL +N D ++ +++ +G G G+V + + RTQ+ A+K+ Sbjct: 2 PLGSEFMAHSPVQSGLPGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKI 61 Query: 95 LQ------DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFS 148 + + ++E+ + + P++ + Y Y L I+ME L GG Sbjct: 62 IDLEEAEDEIEDIQQEITVLSQC-DSPYVTK----YYGSYLKDTKLWIIMEYLGGGSALD 116 Query: 149 RIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDF 208 ++ E + + I++ I + + YLHS HRD+K N+L + + +KL DF Sbjct: 117 LLE---PGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSE---HGEVKLADF 170 Query: 209 GFAKETTSHN-SLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH 267 G A + T T TP+++APEV+ YD D+WSLG+ L G PP H Sbjct: 171 GVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELH 230 Query: 268 GLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 MK + + P E S+ +K + L EP+ R T E + H +I++ Sbjct: 231 P------MKVLFLIPKNNPPTLE-GNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILR 283 Query: 328 STKV 331 + K Sbjct: 284 NAKK 287 >5DYK-A nrPDB Length = 853 Score = 253 bits (647), Expect = 8e-68, Method: Composition-based stats. Identities = 82/295 (27%), Positives = 141/295 (47%), Gaps = 34/295 (11%) Query: 46 FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP------ 99 H++ ++++ + D T +++G G G V + +K T+ ++ALK + Sbjct: 523 AHLEERIKMQDTKVEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQ 582 Query: 100 ----KARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGD 155 K RE+ + P I+R+V +++ K + E + GGEL+ I+ G Sbjct: 583 QNNIKLEREITAE---NDHPFIIRLVRTFKDS----KYFYFLTELVTGGELYDAIRKLG- 634 Query: 156 QAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT 215 ++ +A + SI AI+YLH NI +RD+KPEN+L + +KL DFG AK+ Sbjct: 635 -LLSKSQAQFYLGSIILAIEYLHERNIVYRDLKPENILLDKQ---GYVKLIDFGCAKKV- 689 Query: 216 SHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGM 275 T TP+Y+APEV+ + Y + D+W+LG+ +Y +CG PF ++ + + Sbjct: 690 -QGRAYTLVGTPHYMAPEVILGKGYGCTVDIWALGICLYEFICGPLPFGNDEEDQL--EI 746 Query: 276 KTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRM-----TITEFMNHPWI 325 I GQ FP+ S L++ LL P R+ + +HP+ Sbjct: 747 FRDILTGQLTFPDYVTDTDS---INLMKRLLCRLPQGRIGCSINGFKDIKDHPFF 798 >3TXO-A nrPDB Length = 353 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 80/304 (26%), Positives = 137/304 (45%), Gaps = 33/304 (10%) Query: 39 PPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-- 96 P++ + G+ ID+++ +VLG G GKV+ K T + +A+K+L+ Sbjct: 1 GPKESSKEGNGIGVNSSNRLGIDNFEFI-RVLGKGSFGKVMLARVKETGDLYAVKVLKKD 59 Query: 97 ------DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRI 150 D E + A P + ++ + L VME ++GG+L I Sbjct: 60 VILQDDDVECTMTEKRILSLARNHPFLTQLF----CCFQTPDRLFFVMEFVNGGDLMFHI 115 Query: 151 QDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGF 210 Q + F E A I A+ +LH I +RD+K +N+L + KL DFG Sbjct: 116 QK--SRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHE---GHCKLADFGM 170 Query: 211 AKETTSHNSLT-TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL 269 KE + T T C TP Y+APE+L Y + D W++GV++Y +LCG+ PF + + Sbjct: 171 CKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENED 230 Query: 270 AISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRM-TITE-----FMNHP 323 + + E P W E+ ++++ + PT R+ ++T+ + HP Sbjct: 231 DLFEAILND------EVVYPTWLH--EDATGILKSFMTKNPTMRLGSLTQGGEHAILRHP 282 Query: 324 WIMQ 327 + + Sbjct: 283 FFKE 286 >6AO5-A nrPDB Length = 362 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 76/293 (25%), Positives = 132/293 (45%), Gaps = 19/293 (6%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML---QDCPKARREVELHWRASQCPHI 117 + + V + LG G G V + +K + + A+K + D + +E+ + + P++ Sbjct: 10 EVFDVLEK-LGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQC-DSPYV 67 Query: 118 VRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL 177 V+ Y Y L IVME G + I+ R ++ E E + I+KS + ++YL Sbjct: 68 VK----YYGSYFKNTDLWIVMEYCGAGSVSDIIRLR-NKTLIEDEIATILKSTLKGLEYL 122 Query: 178 HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN-SLTTPCYTPYYVAPEVLG 236 H + HR++K N+L ++ KL DFG A + T T TP+++APEV+ Sbjct: 123 HFMRKIHRNIKAGNILLNTE---GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ 179 Query: 237 PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSE 296 Y+ D+WSLG+ + G PP+ H + + T F PE S+ Sbjct: 180 EIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTN---PPPTFRKPEL--WSD 234 Query: 297 EVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERW 349 + ++ L P QR T T+ + HP+I + V + ++ +R Sbjct: 235 DFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRH 287 >6C9D-A nrPDB Length = 459 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 90/323 (27%), Positives = 144/323 (44%), Gaps = 26/323 (8%) Query: 64 KVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP-------KARREVELHWRASQCPH 116 + +G G KV + T + A+K++ K REV + + P+ Sbjct: 23 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIM-KILNHPN 81 Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 IV++ +V E K L +VME GGE+F + G E+EA + I A+QY Sbjct: 82 IVKLFEVIET----EKTLYLVMEYASGGEVFDYLVAHG--RMKEKEARAKFRQIVSAVQY 135 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 236 H I HRD+K ENLL + +K+ DFGF+ E T N L C +P Y APE+ Sbjct: 136 CHQKYIVHRDLKAENLLLD---GDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQ 192 Query: 237 PEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 295 +KYD D+WSLGVI+Y L+ G PF + ++ R+ G+Y P +S Sbjct: 193 GKKYDGPEVDVWSLGVILYTLVSGSLPFDGQN----LKELRERVLRGKYRIPF----YMS 244 Query: 296 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEE 355 + + L++ LL P +R ++ + M W+ + + +T + + D+ Sbjct: 245 TDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVT 304 Query: 356 MTSALATMRVDYEQIKIKKIEDA 378 M A + K ++ Sbjct: 305 MGFARDEINDALINQKYDEVMAT 327 >2BPM-A nrPDB Length = 309 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 70/302 (23%), Positives = 126/302 (41%), Gaps = 40/302 (13%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK-------ARREVELHWRAS 112 +++++ + +G G G V + NK T E ALK ++ + A RE+ L + Sbjct: 6 MENFQKVEK-IGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISL-LKEL 63 Query: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 P+IV+++DV L +V E L +L + + + + Sbjct: 64 NHPNIVKLLDVIHT----ENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQ 118 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT-SHNSLTTPCYTPYYVA 231 + + HS + HRD+KP+NLL ++ +KL DFG A+ + T T +Y A Sbjct: 119 GLAFCHSHRVLHRDLKPQNLLINTE---GAIKLADFGLARAFGVPVRTYTHEVVTLWYRA 175 Query: 232 PEVLGPEK-YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRI----------- 279 PE+L K Y + D+WSLG I ++ F + + + + Sbjct: 176 PEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGV 235 Query: 280 -RMGQYEFPNPEW---------SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQST 329 M Y+ P+W + E+ + L+ +L +P +R++ + HP+ T Sbjct: 236 TSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVT 295 Query: 330 KV 331 K Sbjct: 296 KP 297 >6CMJ-A nrPDB Length = 321 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 74/311 (23%), Positives = 141/311 (45%), Gaps = 36/311 (11%) Query: 54 IKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARR---------- 103 ++ +D Y + + +G G G V +N+ +A+K+L R+ Sbjct: 27 MQDCVQLDQYTLKDE-IGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGP 85 Query: 104 ------EVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQA 157 E+ + + P++V++V+V ++ L +V E ++ G + + Sbjct: 86 IEQVYQEIAILKKL-DHPNVVKLVEVLDD--PNEDHLYMVFELVNQGPVMEV---PTLKP 139 Query: 158 FTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSH 217 +E +A + + + I+YLH I HRD+KP NLL + +K+ DFG + E Sbjct: 140 LSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGE---DGHIKIADFGVSNEFKGS 196 Query: 218 NS-LTTPCYTPYYVAPEVLGPEK---YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISP 273 ++ L+ TP ++APE L + K+ D+W++GV +Y + G PF + + Sbjct: 197 DALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLH- 255 Query: 274 GMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ 333 ++I+ EFP + +++E++K LI +L P R+ + E HPW+ + P Sbjct: 256 ---SKIKSQALEFP--DQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPL 310 Query: 334 TPLHTSRVLKE 344 + L E Sbjct: 311 PSEDENCTLVE 321 >4JDH-A nrPDB Length = 346 Score = 252 bits (643), Expect = 3e-67, Method: Composition-based stats. Identities = 77/318 (24%), Positives = 141/318 (44%), Gaps = 30/318 (9%) Query: 24 PTPALPHPPAQPPPP-PPQQFPQFHVKSGLQIKKNAIIDD-----YKVTSQVLGLGINGK 77 P +PP P PQ+ PQ + ++D Y +G G G Sbjct: 30 RARQENGMPEKPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGI 89 Query: 78 VLQIFNKRTQEKFALKMLQDCPKARREVELH----WRASQCPHIVRIVDVYENLYAGRKC 133 V + + + A+K + + RRE+ + R Q ++V + + Y Sbjct: 90 VCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY----LVGDE 145 Query: 134 LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL 193 L +VME L+GG L + E + + + ++ +A+ LH+ + HRD+K +++L Sbjct: 146 LWVVMEFLEGGALTDIV---THTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSIL 202 Query: 194 YTSKRPNAILKLTDFGFAKET-TSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVI 252 T + +KL+DFGF + + TPY++APE++ Y D+WSLG++ Sbjct: 203 LTH---DGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIM 259 Query: 253 MYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN--PEWSEVSEEVKMLIRNLLKTEP 310 + ++ G PP+++ L ++M + P +VS +K + LL +P Sbjct: 260 VIEMVDGEPPYFNEPPL-------KAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDP 312 Query: 311 TQRMTITEFMNHPWIMQS 328 QR T E + HP++ ++ Sbjct: 313 AQRATAAELLKHPFLAKA 330 >5FET-A nrPDB Length = 847 Score = 251 bits (642), Expect = 4e-67, Method: Composition-based stats. Identities = 92/351 (26%), Positives = 156/351 (44%), Gaps = 49/351 (13%) Query: 47 HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP------- 99 H++ ++++ + T +++G G G V + +K TQ ++ALK + Sbjct: 518 HLEERIKMQDTKVEMHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQ 577 Query: 100 ---KARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQ 156 K RE+ + P I+R+V +++ C + E + GGEL+ I+ G Sbjct: 578 NNIKLEREITAE---NDHPFIIRLVRTFKDS----NCFYFLTELVTGGELYDAIRKLG-- 628 Query: 157 AFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS 216 ++ +A + SI AI+YLH NI +RD+KPEN+L + +KL DFG AK+ Sbjct: 629 LLSKPQAQFYLGSIILAIEYLHERNIVYRDLKPENILLDKQ---GYVKLIDFGCAKKI-- 683 Query: 217 HNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMK 276 T TP+Y+APEV+ + Y + D+W+LGV +Y +CG PF ++ + + Sbjct: 684 QGRAYTLVGTPHYMAPEVILGKGYGCTVDIWALGVCLYEFICGPLPFGNDQEDQL--EIF 741 Query: 277 TRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRM-----TITEFMNHPWIMQSTKV 331 I GQ FP+ + S L++ LL P R+ + H + Sbjct: 742 RDILTGQLTFPDYVSDQDS---INLMKRLLCRLPQGRIGCSINGFKDIKEHAFF------ 792 Query: 332 PQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPL 382 DK ++ + S T D + +I++ EDA N Sbjct: 793 --------GNFNWDKLAGRLLEPPLVSKGETYAEDIDIKQIEE-EDALNEG 834 >2UV2-A nrPDB Length = 325 Score = 250 bits (640), Expect = 5e-67, Method: Composition-based stats. Identities = 84/305 (27%), Positives = 142/305 (46%), Gaps = 27/305 (8%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARRE---VELHWRAS-QCPH 116 D +++ + LG G GKV + NK T A K++ + E VE+ AS P+ Sbjct: 37 DFWEIIGE-LGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPN 95 Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 IV+++D + L I++E GG + + + + ++ TE + + K +A+ Y Sbjct: 96 IVKLLDAFY----YENNLWILIEFCAGGAVDAVMLE-LERPLTESQIQVVCKQTLDALNY 150 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGF-AKETTSHNSLTTPCYTPYYVAPEVL 235 LH I HRD+K N+L+T + +KL DFG AK T + + TPY++APEV+ Sbjct: 151 LHDNKIIHRDLKAGNILFT---LDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVV 207 Query: 236 G-----PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN-P 289 YD D+WSLG+ + + PP + + M+ +++ + E P Sbjct: 208 MCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNP------MRVLLKIAKSEPPTLA 261 Query: 290 EWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERW 349 + S S K ++ L+ R T ++ + HP++ + P L + E E Sbjct: 262 QPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIREL-IAEAKAEVTEEV 320 Query: 350 EDVKE 354 ED KE Sbjct: 321 EDGKE 325 >5F9E-A nrPDB Length = 353 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 84/294 (28%), Positives = 134/294 (45%), Gaps = 28/294 (9%) Query: 44 PQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARR 103 K ++ I+D+++ ++LG G GKV K+T + FA+K L+ Sbjct: 2 EPELNKERPSLQIKLKIEDFEL-HKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMD 60 Query: 104 --------EVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGD 155 E + A + P + + + ++ L VME L+GG+L IQ Sbjct: 61 DDVECTMVEKRVLSLAWEHPFLTHMF----CTFQTKENLFFVMEYLNGGDLMYHIQSC-- 114 Query: 156 QAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT 215 F A+ I +Q+LHS I +RD+K +N+L + +K+ DFG KE Sbjct: 115 HKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLD---KDGHIKIADFGMCKENM 171 Query: 216 SHNSLTT-PCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPG 274 ++ T C TP Y+APE+L +KY+ S D WS GV++Y +L G PF+ Sbjct: 172 LGDAKTNEFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDE----EE 227 Query: 275 MKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTIT-EFMNHPWIMQ 327 + IRM +P W E +E K L+ L EP +R+ + + HP + Sbjct: 228 LFHSIRMDNPFYPR--WLE--KEAKDLLVKLFVREPEKRLGVRGDIRQHPLFRE 277 >6DTL-A nrPDB Length = 364 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 88/361 (24%), Positives = 148/361 (40%), Gaps = 47/361 (13%) Query: 49 KSGLQIKKNAIIDDYKVTSQ------VLGLGINGKVLQIFNKRTQEKFALKMLQ------ 96 G I+ N + ++VT++ +G G G V N T E A+K + Sbjct: 11 HGGRFIQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNK 70 Query: 97 -DCPKARREVELHWRASQCPHIVRIVDVYENLYAG-RKCLLIVMECLDGGELFSRIQDRG 154 D + RE++L R +IV I D+ + I E +D +L I R Sbjct: 71 IDAKRTLREIKL-LRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQII--RS 126 Query: 155 DQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET 214 +QA +E + I ++Y+HS N+ HRD+KP NLL + N LK+ DFG A+ T Sbjct: 127 NQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNA---NCDLKICDFGLARVT 183 Query: 215 TSHNSLTTPCYTPYYVAPE-VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISP 273 + + +T T +Y APE +L Y + D+WS+G I L+ P F + Sbjct: 184 SESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLR 243 Query: 274 GMKTRI----------------RMGQYEFPNP------EWSEVSEEVKMLIRNLLKTEPT 311 + I R + P P ++ V LI +L +P Sbjct: 244 LLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPR 303 Query: 312 QRMTITEFMNHPW---IMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYE 368 +R+T+ + + HP+ + + P+ + + + E +KE + +Y+ Sbjct: 304 RRITVLDALAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYREALAFNPEYQ 363 Query: 369 Q 369 Q Sbjct: 364 Q 364 >5D9K-A nrPDB Length = 330 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 82/295 (27%), Positives = 137/295 (46%), Gaps = 38/295 (12%) Query: 47 HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNK---RTQEKFALKMLQ------- 96 HVK G + A +++ +VLG G GKV + ++ +A+K+L+ Sbjct: 19 HVKEG---HEKADPSQFELL-KVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVR 74 Query: 97 DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQ 156 D + + E ++ P IV++ ++ L ++++ L GG+LF+R+ + Sbjct: 75 DRVRTKMERDILVEV-NHPFIVKLHYAFQT----EGKLYLILDFLRGGDLFTRLSK--EV 127 Query: 157 AFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS 216 FTE + + + A+ +LHS+ I +RD+KPEN+L + +KLTDFG +KE+ Sbjct: 128 MFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEE---GHIKLTDFGLSKESID 184 Query: 217 HNSL-TTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGM 275 H + C T Y+APEV+ + +S D WS GV+M+ +L G PF Sbjct: 185 HEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKD----RKET 240 Query: 276 KTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTI-----TEFMNHPWI 325 T I + P +S E + L+R L K P R+ E H + Sbjct: 241 MTMILKAKLGMPQ----FLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF 291 >4KS7-A nrPDB Length = 292 Score = 248 bits (634), Expect = 3e-66, Method: Composition-based stats. Identities = 70/272 (25%), Positives = 136/272 (50%), Gaps = 27/272 (9%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELH----WRASQCPHIVRIVDVYE 125 +G G G V K + + A+KM+ + RRE+ + R Q ++V + Y Sbjct: 31 IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSY- 89 Query: 126 NLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHR 185 + L ++ME L GG L + E + + + +++ +A+ YLH+ + HR Sbjct: 90 ---LVGEELWVLMEFLQGGALTDIVSQ---VRLNEEQIATVCEAVLQALAYLHAQGVIHR 143 Query: 186 DVKPENLLYTSKRPNAILKLTDFGFAKETTSHN-SLTTPCYTPYYVAPEVLGPEKYDKSC 244 D+K +++L T + +KL+DFGF + + + TPY++APEV+ Y Sbjct: 144 DIKSDSILLT---LDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEV 200 Query: 245 DMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE---WSEVSEEVKML 301 D+WSLG+++ ++ G PP++S+ + ++ + P P+ +VS ++ Sbjct: 201 DIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLR--------DSPPPKLKNSHKVSPVLRDF 252 Query: 302 IRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ 333 + +L +P +R T E ++HP+++Q T +P+ Sbjct: 253 LERMLVRDPQERATAQELLDHPFLLQ-TGLPE 283 >1CM8-A nrPDB Length = 367 Score = 248 bits (634), Expect = 3e-66, Method: Composition-based stats. Identities = 75/342 (21%), Positives = 141/342 (41%), Gaps = 52/342 (15%) Query: 33 AQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFAL 92 + PPP + Q K+ +++ A+ D Q +G G G V + RT K A+ Sbjct: 2 SSPPPARSGFYRQEVTKTAWEVR--AVYRDL----QPVGSGAYGAVCSAVDGRTGAKVAI 55 Query: 93 KMLQD-------CPKARREVELHWRASQCPHIVRIVDVY--ENLYAGRKCLLIVMECLDG 143 K L +A RE+ L + + +++ ++DV+ + +VM + G Sbjct: 56 KKLYRPFQSELFAKRAYRELRL-LKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-G 113 Query: 144 GELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAIL 203 +L ++ + E ++ + + ++Y+H+ I HRD+KP NL + L Sbjct: 114 TDLGKLMKH---EKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNE---DCEL 167 Query: 204 KLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPP 262 K+ DFG A++ + + +T T +Y APEV+ +Y ++ D+WS+G IM ++ G Sbjct: 168 KILDFGLARQ--ADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTL 225 Query: 263 FYSNHGLAISPGMK-------------------TRIRMGQYEFPNPEWSEV----SEEVK 299 F + L + G E +++ + S Sbjct: 226 FKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAV 285 Query: 300 MLIRNLLKTEPTQRMTITEFMNHPWIM---QSTKVPQTPLHT 338 L+ +L + QR+T E + HP+ + PQ + Sbjct: 286 NLLEKMLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYD 327 >3NIZ-A nrPDB Length = 311 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 75/302 (24%), Positives = 127/302 (42%), Gaps = 43/302 (14%) Query: 57 NAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK-------ARREVELHW 109 +++ Y+ +V G G G V + + + ALK ++ + A RE+ L Sbjct: 17 QGLMEKYQKLEKV-GEGTYGVVYKAKDSQ-GRIVALKRIRLDAEDEGIPSTAIREISL-L 73 Query: 110 RASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 169 + P+IV ++DV + +CL +V E ++ +L + D + + + Sbjct: 74 KELHHPNIVSLIDVIHS----ERCLTLVFEFMEK-DLKKVL-DENKTGLQDSQIKIYLYQ 127 Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT-SHNSLTTPCYTPY 228 + + + H I HRD+KP+NLL S + LKL DFG A+ S T T + Sbjct: 128 LLRGVAHCHQHRILHRDLKPQNLLINS---DGALKLADFGLARAFGIPVRSYTHEVVTLW 184 Query: 229 YVAPEVLGP-EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE-- 285 Y AP+VL +KY S D+WS+G I ++ G P F P + + + Sbjct: 185 YRAPDVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREW 244 Query: 286 ----------------FPNPEWSEVSE----EVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 F WS + E L+ N+L +P +R++ + MNHP+ Sbjct: 245 PQVQELPLWKQRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYF 304 Query: 326 MQ 327 Sbjct: 305 KD 306 >3DB8-A nrPDB Length = 317 Score = 248 bits (633), Expect = 4e-66, Method: Composition-based stats. Identities = 81/319 (25%), Positives = 133/319 (41%), Gaps = 34/319 (10%) Query: 26 PALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKR 85 P+ P P + + +K+ + + LG G K +I + Sbjct: 13 PSAKPSAHVDPKSAPLKEIPDVLVDPRTMKR-------YMRGRFLGKGGFAKCYEITDMD 65 Query: 86 TQEKFALKMLQDC--------PKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIV 137 T+E FA K++ K E+ +H ++ PH+V +E+ + +V Sbjct: 66 TKEVFAGKVVPKSMLLKPHQKEKMSTEIAIH-KSLDNPHVVGFHGFFED----DDFVYVV 120 Query: 138 MECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSK 197 +E L + R +A TE EA M+ + +QYLH+ + HRD+K NL Sbjct: 121 LEICRRRSLLELHKRR--KAVTEPEARYFMRQTIQGVQYLHNNRVIHRDLKLGNLFLND- 177 Query: 198 RPNAILKLTDFGFAKETT-SHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYIL 256 + +K+ DFG A + C TP Y+APEVL + + D+WSLG I+Y L Sbjct: 178 --DMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVLCKKGHSFEVDIWSLGCILYTL 235 Query: 257 LCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTI 316 L G PPF + + RI+ +Y P ++ LIR +L +PT R ++ Sbjct: 236 LVGKPPFET----SCLKETYIRIKKNEYSVPR----HINPVASALIRRMLHADPTLRPSV 287 Query: 317 TEFMNHPWIMQSTKVPQTP 335 E + + + P Sbjct: 288 AELLTDEFFTSGYAPMRLP 306 >4B6L-A nrPDB Length = 281 Score = 248 bits (633), Expect = 4e-66, Method: Composition-based stats. Identities = 78/285 (27%), Positives = 121/285 (42%), Gaps = 27/285 (9%) Query: 64 KVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC--------PKARREVELHWRASQCP 115 + ++LG G + + + T +A+K++ K E+ELH R Q Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELH-RDLQHR 69 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 HIVR +E+ + I +E L + R E E ++ I ++ Sbjct: 70 HIVRFSHHFEDA----DNIYIFLELCSRKSLAHIWKAR--HTLLEPEVRYYLRQILSGLK 123 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFA-KETTSHNSLTTPCYTPYYVAPEV 234 YLH I HRD+K N T N LK+ DFG A + T C TP YVAPEV Sbjct: 124 YLHQRGILHRDLKLGNFFITE---NMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEV 180 Query: 235 LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 294 L + + D+WSLG +MY LLCG PPF + I+ Y P + + Sbjct: 181 LLRQGHGPEADVWSLGCVMYTLLCGSPPFETAD----LKETYRCIKQVHYTLP----ASL 232 Query: 295 SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTS 339 S + L+ +L+ P R +I + + H + + + P+ + Sbjct: 233 SLPARQLLAAILRASPRDRPSIDQILRHDFFTKGYTPDRLPISSC 277 >5AWM-A nrPDB Length = 394 Score = 248 bits (633), Expect = 4e-66, Method: Composition-based stats. Identities = 77/364 (21%), Positives = 144/364 (39%), Gaps = 61/364 (16%) Query: 47 HVKSGLQIKK-NAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-------DC 98 H +++ N I + + +G G G V ++ TQ+ A+K L Sbjct: 28 HQHYTVEVGDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHA 87 Query: 99 PKARREVELHWRASQCPHIVRIVDVY--ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQ 156 +A RE +L + +I+ +++ + + + + +VME +D L IQ D Sbjct: 88 KRAYREFKLM-KLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQMDLDH 145 Query: 157 AFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS 216 S ++ + I++LHS I HRD+KP N++ + + LK+ DFG A+ + Sbjct: 146 ----DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV---KADCTLKILDFGLARTAGT 198 Query: 217 HNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLA------ 270 +T T YY APEV+ Y ++ D+WS+G IM ++ G F + Sbjct: 199 TFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKII 258 Query: 271 -----------------ISPGMKTRIRMGQYEFPNPEWSEVSE------------EVKML 301 + ++ R R Y F + + + L Sbjct: 259 EQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNL 318 Query: 302 IRNLLKTEPTQRMTITEFMNHPWI-------MQSTKVPQTPLHTSRVLKEDKERWEDVKE 354 + +L +P QR+++ E + H +I P+ H+ + E+W+++ Sbjct: 319 LSKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDHSVDEREHTVEQWKELIY 378 Query: 355 EMTS 358 E Sbjct: 379 EEVM 382 >4RA4-A nrPDB Length = 355 Score = 248 bits (633), Expect = 4e-66, Method: Composition-based stats. Identities = 72/273 (26%), Positives = 122/273 (44%), Gaps = 31/273 (11%) Query: 69 VLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARR--------EVELHWRASQCPHIVRI 120 VLG G GKV+ K T+E +A+K+L+ + E + + P + ++ Sbjct: 27 VLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQL 86 Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 ++ + L VME ++GG+L IQ G F E +A I + +LH Sbjct: 87 HSCFQTV----DRLYFVMEYVNGGDLMYHIQQVG--KFKEPQAVFYAAEISIGLFFLHKR 140 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYYVAPEVLGPEK 239 I +RD+K +N++ S+ +K+ DFG KE + T C TP Y+APE++ + Sbjct: 141 GIIYRDLKLDNVMLDSE---GHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQP 197 Query: 240 YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVK 299 Y KS D W+ GV++Y +L G PPF + I +P +S+E Sbjct: 198 YGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQS----IMEHNVSYP----KSLSKEAV 249 Query: 300 MLIRNLLKTEPTQRMTI-----TEFMNHPWIMQ 327 + + L+ P +R+ + H + + Sbjct: 250 SICKGLMTKHPAKRLGCGPEGERDVREHAFFRR 282 >4FZF-B nrPDB Length = 283 Score = 247 bits (632), Expect = 5e-66, Method: Composition-based stats. Identities = 76/296 (25%), Positives = 130/296 (43%), Gaps = 27/296 (9%) Query: 57 NAIIDDYKVTSQV--LGLGINGKVLQIFNKRTQEKFALKMLQ------DCPKARREVELH 108 A+ D ++ +++ +G G G+V + + RTQ+ A+K++ + ++E+ + Sbjct: 1 GAMADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITV- 59 Query: 109 WRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMK 168 SQC V Y Y L I+ME L GG ++ F E + + ++K Sbjct: 60 --LSQCDS--SYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA---GPFDEFQIATMLK 112 Query: 169 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN-SLTTPCYTP 227 I + + YLHS HRD+K N+L + + +KL FG A + T T TP Sbjct: 113 EILKGLDYLHSEKKIHRDIKAANVLLSEQ---GDVKLAAFGVAGQLTDTQIKRNTFVGTP 169 Query: 228 YYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 +++APEV+ YD D+WSLG+ L G PP H + + + P Sbjct: 170 FWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNN-------P 222 Query: 288 NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLK 343 + ++ K I L +P+ R T E + H +I++++K K Sbjct: 223 PTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFK 278 >2XIK-A nrPDB Length = 294 Score = 247 bits (631), Expect = 6e-66, Method: Composition-based stats. Identities = 75/287 (26%), Positives = 128/287 (44%), Gaps = 27/287 (9%) Query: 54 IKKNAIIDDYKVTSQV--LGLGINGKVLQIFNKRTQEKFALKMLQ------DCPKARREV 105 +++ +D ++ +++ +G G G+V + + T+E A+K++ + ++E+ Sbjct: 9 ANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEI 68 Query: 106 ELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASE 165 + + P+I R Y Y L I+ME L GG ++ E + Sbjct: 69 TVLSQC-DSPYITR----YFGSYLKSTKLWIIMEYLGGGSALDLLK---PGPLEETYIAT 120 Query: 166 IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN-SLTTPC 224 I++ I + + YLHS HRD+K N+L + + +KL DFG A + T T Sbjct: 121 ILREILKGLDYLHSERKIHRDIKAANVLLSEQ---GDVKLADFGVAGQLTDTQIKRNTFV 177 Query: 225 YTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQY 284 TP+++APEV+ YD D+WSLG+ L G PP H M+ + + Sbjct: 178 GTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHP------MRVLFLIPKN 231 Query: 285 EFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKV 331 P E S+ K + L +P R T E + H +I + TK Sbjct: 232 SPPTLEGQH-SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKK 277 >4J52-A nrPDB Length = 293 Score = 247 bits (631), Expect = 7e-66, Method: Composition-based stats. Identities = 80/276 (28%), Positives = 123/276 (44%), Gaps = 27/276 (9%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQDC--------PKARREVELHWRASQCPHIVRIV 121 LG G K +I + T+E FA K++ K E+ +H R+ H+V Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIH-RSLAHQHVVGFH 80 Query: 122 DVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN 181 +E+ + +V+E L + R +A TE EA ++ I QYLH Sbjct: 81 GFFED----NDFVFVVLELCRRRSLLELHKRR--KALTEPEARYYLRQIVLGCQYLHRNR 134 Query: 182 IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT-SHNSLTTPCYTPYYVAPEVLGPEKY 240 + HRD+K NL + +K+ DFG A + C TP Y+APEVL + + Sbjct: 135 VIHRDLKLGNLFLNE---DLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGH 191 Query: 241 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 300 D+WS+G IMY LL G PPF + + RI+ +Y P ++ Sbjct: 192 SFEVDVWSIGCIMYTLLVGKPPFET----SCLKETYLRIKKNEYSIP----KHINPVAAS 243 Query: 301 LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPL 336 LI+ +L+T+PT R TI E +N + + P+ Sbjct: 244 LIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPI 279 >2OU7-A nrPDB Length = 335 Score = 246 bits (629), Expect = 9e-66, Method: Composition-based stats. Identities = 80/276 (28%), Positives = 123/276 (44%), Gaps = 27/276 (9%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQDC--------PKARREVELHWRASQCPHIVRIV 121 LG G K +I + T+E FA K++ K E+ +H R+ H+V Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIH-RSLAHQHVVGFH 107 Query: 122 DVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN 181 +E+ + +V+E L + R +A TE EA ++ I QYLH Sbjct: 108 GFFED----NDFVFVVLELCRRRSLLELHKRR--KALTEPEARYYLRQIVLGCQYLHRNR 161 Query: 182 IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT-SHNSLTTPCYTPYYVAPEVLGPEKY 240 + HRD+K NL + +K+ DFG A + C TP Y+APEVL + + Sbjct: 162 VIHRDLKLGNLFLNE---DLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGH 218 Query: 241 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 300 D+WS+G IMY LL G PPF + + RI+ +Y P ++ Sbjct: 219 SFEVDVWSIGCIMYTLLVGKPPFET----SCLKETYLRIKKNEYSIP----KHINPVAAS 270 Query: 301 LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPL 336 LI+ +L+T+PT R TI E +N + + P+ Sbjct: 271 LIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPI 306 >5Z33-A nrPDB Length = 425 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 81/349 (23%), Positives = 144/349 (41%), Gaps = 49/349 (14%) Query: 54 IKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC-------PKARREVE 106 ++ I+D+ ++ LG G G V N +T E A+K + + +A RE++ Sbjct: 23 FNQDFIVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIK 82 Query: 107 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 L +I + D+ + E ++ +L + I R Q T+ Sbjct: 83 LLQHFRGHRNITCLYDMDIPRPDNFNETYLYEELMEC-DLAAII--RSGQPLTDAHFQSF 139 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSH-----NSLT 221 + I ++Y+HS N+ HRD+KP NLL + + LK+ DFG A+ + +T Sbjct: 140 IYQILCGLKYIHSANVLHRDLKPGNLLVNA---DCELKICDFGLARGFSVDPEENAGYMT 196 Query: 222 TPCYTPYYVAPEV-LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRI- 279 T +Y APE+ L + Y K+ D+WS+G I+ LL G P F + + + Sbjct: 197 EYVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILG 256 Query: 280 -------------RMGQY--------EFPNPE-WSEVSEEVKMLIRNLLKTEPTQRMTIT 317 R +Y + P P + + + L+ +L +P+ R+++ Sbjct: 257 TPNEETLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVE 316 Query: 318 EFMNHPWI---MQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATM 363 + + HP++ ++ P P D E EDV E L + Sbjct: 317 QALEHPYLHIWHDASDEPDCPT----TFNFDFEVVEDVGEMRKMILDEV 361 >4L42-A nrPDB Length = 346 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 81/282 (28%), Positives = 133/282 (47%), Gaps = 37/282 (13%) Query: 63 YKVTSQVLGLGINGKVLQIFNK---RTQEKFALKMLQDCPKARR---------EVELHWR 110 +++ +VLG G GKV Q+ T + FA+K+L+ R E + Sbjct: 20 FELL-RVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNI-LE 77 Query: 111 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 + P IV ++ ++ L +++E L GGELF +++ G F E A + I Sbjct: 78 EVKHPFIVDLIYAFQT----GGKLYLILEYLSGGELFMQLEREG--IFMEDTACFYLAEI 131 Query: 171 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TPCYTPYY 229 A+ +LH I +RD+KPEN++ + +KLTDFG KE+ ++T T C T Y Sbjct: 132 SMALGHLHQKGIIYRDLKPENIMLNHQ---GHVKLTDFGLCKESIHDGTVTHTFCGTIEY 188 Query: 230 VAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNP 289 +APE+L ++++ D WSLG +MY +L G PPF + +I + P Sbjct: 189 MAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTID----KILKCKLNLP-- 242 Query: 290 EWSEVSEEVKMLIRNLLKTEPTQRMT-----ITEFMNHPWIM 326 +++E + L++ LLK R+ E HP+ Sbjct: 243 --PYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFR 282 >1TKI-A nrPDB Length = 321 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 80/307 (26%), Positives = 152/307 (49%), Gaps = 17/307 (5%) Query: 64 KVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ----DCPKARREVELHWRASQCPHIVR 119 + ++ LG G G V + +++ + K ++ D ++E+ + ++ +I+ Sbjct: 7 YMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISI-LNIARHRNILH 65 Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 + + +E++ L+++ E + G ++F RI + ERE + + EA+Q+LHS Sbjct: 66 LHESFESMEE----LVMIFEFISGLDIFERINTSAFE-LNEREIVSYVHQVCEALQFLHS 120 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEK 239 NI H D++PEN++Y ++R ++ +K+ +FG A++ ++ P Y APEV + Sbjct: 121 HNIGHFDIRPENIIYQTRR-SSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDV 179 Query: 240 YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVK 299 + DMWSLG ++Y+LL G PF + I I +Y F + E+S E Sbjct: 180 VSTATDMWSLGTLVYVLLSGINPFLAETNQQIIE----NIMNAEYTFDEEAFKEISIEAM 235 Query: 300 MLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSA 359 + LL E RMT +E + HPW+ Q K+ + R LK + +K+++ Sbjct: 236 DFVDRLLVKERKSRMTASEALQHPWLKQ--KIERVSTKVIRTLKHRRYYHTLIKKDLNMV 293 Query: 360 LATMRVD 366 ++ R+ Sbjct: 294 VSAARIS 300 >4XBR-A nrPDB Length = 366 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 73/302 (24%), Positives = 136/302 (45%), Gaps = 29/302 (9%) Query: 39 PPQQFPQFHVKSGLQIKKNAIIDD-----YKVTSQVLGLGINGKVLQIFNKRTQEKFALK 93 PQ+ PQ + ++D Y +G G G V + + + A+K Sbjct: 66 SPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVK 125 Query: 94 MLQDCPKARREVELH----WRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSR 149 + + RRE+ + R Q ++V + + Y L +VME L+GG L Sbjct: 126 KMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY----LVGDELWVVMEFLEGGALTDI 181 Query: 150 IQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFG 209 + E + + + ++ +A+ LH+ + HRD+K +++L T + +KL+DFG Sbjct: 182 V---THTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTH---DGRVKLSDFG 235 Query: 210 FAKET-TSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHG 268 F + + TPY++APE++ Y D+WSLG+++ ++ G PP+++ Sbjct: 236 FCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP 295 Query: 269 LAISPGMKTRIRMGQYEFPN--PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIM 326 L ++M + P +VS +K + LL +P QR T E + HP++ Sbjct: 296 L-------KAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLA 348 Query: 327 QS 328 ++ Sbjct: 349 KA 350 >3Q53-A nrPDB Length = 306 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 70/264 (26%), Positives = 132/264 (50%), Gaps = 20/264 (7%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELH----WRASQCPHIVRIVDV 123 + +G G +G V + T ++ A++ + + ++E+ ++ R ++ P+IV +D Sbjct: 27 EKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKNPNIVNYLDS 86 Query: 124 YENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIA 183 Y L +VME L GG L + + E + + + + +A+++LHS + Sbjct: 87 Y----LVGDELWVVMEYLAGGSLTDVVTE---TCMDEGQIAAVCRECLQALEFLHSNQVI 139 Query: 184 HRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS-LTTPCYTPYYVAPEVLGPEKYDK 242 HRD+K +N+L + +KLTDFGF + T S +T TPY++APEV+ + Y Sbjct: 140 HRDIKSDNILLG---MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGP 196 Query: 243 SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI 302 D+WSLG++ ++ G PP+ + + L + T G E NPE ++S + + Sbjct: 197 KVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATN---GTPELQNPE--KLSAIFRDFL 251 Query: 303 RNLLKTEPTQRMTITEFMNHPWIM 326 L+ + +R + E + H ++ Sbjct: 252 NRCLEMDVEKRGSAKELIQHQFLK 275 >4RLP-A nrPDB Length = 288 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 81/282 (28%), Positives = 133/282 (47%), Gaps = 37/282 (13%) Query: 63 YKVTSQVLGLGINGKVLQIFNK---RTQEKFALKMLQDCPKARR---------EVELHWR 110 +++ +VLG G GKV Q+ T + FA+K+L+ R E + Sbjct: 7 FELL-RVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNI-LE 64 Query: 111 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 + P IV ++ ++ L +++E L GGELF +++ G F E A + I Sbjct: 65 EVKHPFIVDLIYAFQT----GGKLYLILEYLSGGELFMQLEREG--IFMEDTACFYLAEI 118 Query: 171 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TPCYTPYY 229 A+ +LH I +RD+KPEN++ + +KLTDFG KE+ ++T T C T Y Sbjct: 119 SMALGHLHQKGIIYRDLKPENIMLNHQ---GHVKLTDFGLCKESIHDGTVTHTFCGTIEY 175 Query: 230 VAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNP 289 +APE+L ++++ D WSLG +MY +L G PPF + +I + P Sbjct: 176 MAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTID----KILKCKLNLP-- 229 Query: 290 EWSEVSEEVKMLIRNLLKTEPTQRMT-----ITEFMNHPWIM 326 +++E + L++ LLK R+ E HP+ Sbjct: 230 --PYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFR 269 >2Q0N-A nrPDB Length = 301 Score = 246 bits (628), Expect = 2e-65, Method: Composition-based stats. Identities = 73/302 (24%), Positives = 136/302 (45%), Gaps = 29/302 (9%) Query: 39 PPQQFPQFHVKSGLQIKKNAIIDD-----YKVTSQVLGLGINGKVLQIFNKRTQEKFALK 93 PQ+ PQ + ++D Y +G G G V + + + A+K Sbjct: 1 SPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVK 60 Query: 94 MLQDCPKARREVELH----WRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSR 149 + + RRE+ + R Q ++V + + Y L +VME L+GG L Sbjct: 61 KMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY----LVGDELWVVMEFLEGGALTDI 116 Query: 150 IQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFG 209 + E + + + ++ +A+ LH+ + HRD+K +++L T + +KL+DFG Sbjct: 117 V---THTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTH---DGRVKLSDFG 170 Query: 210 FAKET-TSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHG 268 F + + TPY++APE++ Y D+WSLG+++ ++ G PP+++ Sbjct: 171 FCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP 230 Query: 269 LAISPGMKTRIRMGQYEFPN--PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIM 326 L ++M + P +VS +K + LL +P QR T E + HP++ Sbjct: 231 L-------KAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLA 283 Query: 327 QS 328 ++ Sbjct: 284 KA 285 >2F57-A nrPDB Length = 317 Score = 245 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 73/264 (27%), Positives = 129/264 (48%), Gaps = 24/264 (9%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELH----WRASQCPHIVRIVDVYE 125 +G G G V K T ++ A+K + + RRE+ + R ++V D+Y Sbjct: 53 IGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVV---DMYS 109 Query: 126 NLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHR 185 + G + L +VME L+GG L + E + + + S+ A+ YLH+ + HR Sbjct: 110 SYLVGDE-LWVVMEFLEGGALTDIV---THTRMNEEQIATVCLSVLRALSYLHNQGVIHR 165 Query: 186 DVKPENLLYTSKRPNAILKLTDFGFAKET-TSHNSLTTPCYTPYYVAPEVLGPEKYDKSC 244 D+K +++L TS + +KL+DFGF + + TPY++APEV+ Y Sbjct: 166 DIKSDSILLTS---DGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEV 222 Query: 245 DMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN--PEWSEVSEEVKMLI 302 D+WSLG+++ ++ G PP+++ L +R + P + +VS ++ + Sbjct: 223 DIWSLGIMVIEMIDGEPPYFNEPPLQA-------MRRIRDSLPPRVKDLHKVSSVLRGFL 275 Query: 303 RNLLKTEPTQRMTITEFMNHPWIM 326 +L EP+QR T E + HP++ Sbjct: 276 DLMLVREPSQRATAQELLGHPFLK 299 >3HKO-A nrPDB Length = 345 Score = 245 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 88/317 (27%), Positives = 137/317 (43%), Gaps = 65/317 (20%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKML----------QDCPKARREVELHWRASQCPHIVR 119 +G G G V +T+ A+K++ +D + + EV L + P+I R Sbjct: 34 IGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKL-HHPNIAR 92 Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRI----------------------------- 150 + +VYE+ + + +VME GG L ++ Sbjct: 93 LYEVYED----EQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECNEE 148 Query: 151 ---------QDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNA 201 ++ D E+ S IM+ I A+ YLH+ I HRD+KPEN L+ S + Sbjct: 149 AINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLF-STNKSF 207 Query: 202 ILKLTDFGFAKET-----TSHNSLTTPCYTPYYVAPEVLG--PEKYDKSCDMWSLGVIMY 254 +KL DFG +KE + +TT TPY+VAPEVL E Y CD WS GV+++ Sbjct: 208 EIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVLLH 267 Query: 255 ILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRM 314 +LL G PF + + + + F NP ++ +S + L+ NLL +R Sbjct: 268 LLLMGAVPFPGVNDADTISQVLNK----KLCFENPNYNVLSPLARDLLSNLLNRNVDERF 323 Query: 315 TITEFMNHPWIMQSTKV 331 + HPWI Q + Sbjct: 324 DAMRALQHPWISQFSDK 340 >4I6B-A nrPDB Length = 308 Score = 245 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 70/270 (25%), Positives = 119/270 (44%), Gaps = 27/270 (10%) Query: 67 SQVLGLGINGKVLQIFNKRTQEKFALKMLQDC--------PKARREVELHWRASQCPHIV 118 + LG G K ++ + + +A K++ K +E+ELH R H+V Sbjct: 33 GKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELH-RILHHKHVV 91 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 + +E+ ++ + I++E + ++ R + TE E ++ I ++YLH Sbjct: 92 QFYHYFED----KENIYILLEYCSRRSMAHILKAR--KVLTEPEVRYYLRQIVSGLKYLH 145 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS-HNSLTTPCYTPYYVAPEVLGP 237 I HRD+K N LK+ DFG A + T C TP Y++PEVL Sbjct: 146 EQEILHRDLKLGNFFINESME---LKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNK 202 Query: 238 EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEE 297 + + D+W+LG +MY +L G PPF + + IR +Y P S + Sbjct: 203 QGHGAESDIWALGCVMYTMLLGRPPFETTN----LKETYRSIREARYTMP----SSLLAP 254 Query: 298 VKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 K LI ++L P R ++ + + H + Q Sbjct: 255 AKHLIASMLSKNPEDRPSLDDIIRHDFFTQ 284 >4AGU-A nrPDB Length = 311 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 74/299 (24%), Positives = 133/299 (44%), Gaps = 43/299 (14%) Query: 59 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC-------PKARREVELHWRA 111 +++ Y+ + +G G G V + N+ T + A+K + A RE+ + Sbjct: 1 MMEKYEKIGK-IGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIR-MLKQ 58 Query: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 + P++V +++V+ ++ L +V E D L DR + E I Sbjct: 59 LKHPNLVNLLEVFR----RKRRLHLVFEYCDHTVLHEL--DRYQRGVPEHLVKSITWQTL 112 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT-SHNSLTTPCYTPYYV 230 +A+ + H N HRDVKPEN+L T ++++KL DFGFA+ T + T +Y Sbjct: 113 QAVNFCHKHNCIHRDVKPENILIT---KHSVIKLCDFGFARLLTGPSDYYDDEVATRWYR 169 Query: 231 APEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL-----------AISPGMKTR 278 +PE+L G +Y D+W++G + LL G P + + + P + Sbjct: 170 SPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQV 229 Query: 279 IRMGQY----EFPNPE--------WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 QY + P+PE + +S L++ L +PT+R+T + ++HP+ Sbjct: 230 FSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYF 288 >2Z7Q-A nrPDB Length = 321 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 80/310 (25%), Positives = 137/310 (44%), Gaps = 38/310 (12%) Query: 31 PPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNK---RTQ 87 P++ + HVK+G + + + +VLG G GKV + + Sbjct: 1 QPSKDEGVLKEISITHHVKAGSEKADPSHFE----LLKVLGQGSFGKVFLVRKVTRPDSG 56 Query: 88 EKFALKMLQ-------DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMEC 140 +A+K+L+ D + + E ++ P +V++ ++ L ++++ Sbjct: 57 HLYAMKVLKKATLKVRDRVRTKMERDILA-DVNHPFVVKLHYAFQT----EGKLYLILDF 111 Query: 141 LDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPN 200 L GG+LF+R+ + FTE + + + + +LHS+ I +RD+KPEN+L + Sbjct: 112 LRGGDLFTRLSK--EVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEE--- 166 Query: 201 AILKLTDFGFAKETTSHNSL-TTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCG 259 +KLTDFG +KE H + C T Y+APEV+ + + S D WS GV+M+ +L G Sbjct: 167 GHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTG 226 Query: 260 YPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRM----- 314 PF T I + P +S E + L+R L K P R+ Sbjct: 227 SLPFQGKD----RKETMTLILKAKLGMPQ----FLSTEAQSLLRALFKRNPANRLGSGPD 278 Query: 315 TITEFMNHPW 324 E H + Sbjct: 279 GAEEIKRHVF 288 >4B8L-A nrPDB Length = 286 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 88/298 (29%), Positives = 144/298 (48%), Gaps = 28/298 (9%) Query: 55 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP--------KARREVE 106 K+ IDD+ + + LG G G V K+ + ALK+L + RRE+E Sbjct: 9 KRKFTIDDFDI-GRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIE 67 Query: 107 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 + + P+I+R+ + + + RK + +++E GEL+ +Q G F E+ ++ Sbjct: 68 IQS-HLRHPNILRMYNYFHD----RKRIYLMLEFAPRGELYKELQKHG--RFDEQRSATF 120 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 226 M+ + +A+ Y H + HRD+KPENLL K LK+ DFG++ S T C T Sbjct: 121 MEELADALHYCHERKVIHRDIKPENLLMGYK---GELKIADFGWSVHAPSLRR-RTMCGT 176 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286 Y+ PE++ + +D+ D+W GV+ Y L G PPF S RI +F Sbjct: 177 LDYLPPEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETH----RRIVNVDLKF 232 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKE 344 P +S+ K LI LL+ P QR+ + M HPW+ +++ ++ S K+ Sbjct: 233 P----PFLSDGSKDLISKLLRYHPPQRLPLKGVMEHPWVKANSRRVLPGVYQSTQSKD 286 >1VZO-A nrPDB Length = 355 Score = 244 bits (624), Expect = 4e-65, Method: Composition-based stats. Identities = 82/289 (28%), Positives = 137/289 (47%), Gaps = 35/289 (12%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFN---KRTQEKFALKMLQDC---------PKARREVEL 107 I+++++ +VLG G GKV + T + +A+K+L+ R E ++ Sbjct: 53 IENFELL-KVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQV 111 Query: 108 HWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIM 167 Q P +V + ++ L ++++ ++GGELF+ + R + FTE E + Sbjct: 112 LEHIRQSPFLVTLHYAFQT----ETKLHLILDYINGGELFTHLSQR--ERFTEHEVQIYV 165 Query: 168 KSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET--TSHNSLTTPCY 225 I A+++LH + I +RD+K EN+L S N + LTDFG +KE C Sbjct: 166 GEIVLALEHLHKLGIIYRDIKLENILLDS---NGHVVLTDFGLSKEFVADETERAYDFCG 222 Query: 226 TPYYVAPEVLGPE--KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQ 283 T Y+AP+++ +DK+ D WSLGV+MY LL G PF + + RI + Sbjct: 223 TIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSE 282 Query: 284 YEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMT-----ITEFMNHPWIMQ 327 +P E+S K LI+ LL +P +R+ E H + + Sbjct: 283 PPYPQ----EMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQK 327 >3NYO-A nrPDB Length = 576 Score = 244 bits (623), Expect = 5e-65, Method: Composition-based stats. Identities = 70/299 (23%), Positives = 123/299 (41%), Gaps = 27/299 (9%) Query: 42 QFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC--- 98 F +F L+ + + + +VLG G G+V + T + +A K L+ Sbjct: 166 YFNRFLQWKWLE--RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIK 223 Query: 99 -----PKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDR 153 A E ++ + +V + YE + L +V+ ++GG+L I Sbjct: 224 KRKGEAMALNEKQILEKV-NSRFVVSLAYAYET----KDALCLVLTLMNGGDLKFHIYHM 278 Query: 154 GDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE 213 G F E A I ++ LH I +RD+KPEN+L + ++++D G A Sbjct: 279 GQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDD---HGHIRISDLGLAVH 335 Query: 214 TTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISP 273 ++ T Y+APEV+ E+Y S D W+LG ++Y ++ G PF Sbjct: 336 VPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKRE 395 Query: 274 GMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRM-----TITEFMNHPWIMQ 327 ++ ++ E P S + + L LL +P +R+ + E HP + Sbjct: 396 EVERLVK----EVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 >3E7O-A nrPDB Length = 360 Score = 244 bits (623), Expect = 6e-65, Method: Composition-based stats. Identities = 74/331 (22%), Positives = 133/331 (40%), Gaps = 52/331 (15%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRI 120 + +G G G V F+ A+K L +A RE+ + + +I+ + Sbjct: 28 KPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYREL-VLLKCVNHKNIISL 86 Query: 121 VDVY--ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 ++V+ + + + +VME +D L I D S ++ + I++LH Sbjct: 87 LNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIHMELDH----ERMSYLLYQMLCGIKHLH 141 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPE 238 S I HRD+KP N++ + + LK+ DFG A+ +++ +T T YY APEV+ Sbjct: 142 SAGIIHRDLKPSNIVV---KSDCTLKILDFGLARTASTNFMMTPYVVTRYYRAPEVILGM 198 Query: 239 KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP----------- 287 Y ++ D+WS+G IM L+ G F + + ++ EF Sbjct: 199 GYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTVRNYV 258 Query: 288 --------------NPEWSEVSEE---------VKMLIRNLLKTEPTQRMTITEFMNHPW 324 P+W SE + L+ +L +P +R+++ E + HP+ Sbjct: 259 ENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPY 318 Query: 325 IMQSTKVPQTPLHTSRVLKEDKERWEDVKEE 355 I + ++ E E EE Sbjct: 319 ITVWYDPAEAEAPPPQIYDAQLEEREHAIEE 349 >4TNB-A nrPDB Length = 590 Score = 244 bits (622), Expect = 6e-65, Method: Composition-based stats. Identities = 71/298 (23%), Positives = 125/298 (41%), Gaps = 27/298 (9%) Query: 42 QFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKA 101 F +F L+ + + + +VLG G G+V + T + +A K L+ Sbjct: 166 FFDRFLQWKWLE--RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIK 223 Query: 102 RR--------EVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDR 153 +R E ++ + +V + YE + L +V+ ++GG+L I + Sbjct: 224 KRKGESMALNEKQILEKV-NSQFVVNLAYAYET----KDALCLVLTIMNGGDLKFHIYNM 278 Query: 154 GDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE 213 G+ F E A I ++ LH N +RD+KPEN+L ++++D G A + Sbjct: 279 GNPGFEEERALFYAAEILCGLEDLHHENTVYRDLKPENILLDDY---GHIRISDLGLAVK 335 Query: 214 TTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISP 273 + + T Y+APEVL ++Y S D W LG ++Y ++ G PF Sbjct: 336 IPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKRE 395 Query: 274 GMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMT-----ITEFMNHPWIM 326 + R+ + + + SEE K + + LL + QR+ E HP+ Sbjct: 396 EVDRRVLETEEVYS----HKFSEEAKSICKMLLTKDAKQRLGCQEEEAAEVKRHPFFR 449 >5YV8-A nrPDB Length = 298 Score = 244 bits (622), Expect = 8e-65, Method: Composition-based stats. Identities = 69/299 (23%), Positives = 130/299 (43%), Gaps = 50/299 (16%) Query: 64 KVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARR-------------------- 103 +G G G V +N+ +A+K+L R+ Sbjct: 15 YTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCI 74 Query: 104 -----------EVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQD 152 E+ + + P++V++V+V ++ L +V E ++ G + Sbjct: 75 QPRGPIEQVYQEIAILKKL-DHPNVVKLVEVLDD--PNEDHLYMVFELVNQGPVMEV--- 128 Query: 153 RGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK 212 + +E +A + + + I+YLH I HRD+KP NLL + +K+ DFG + Sbjct: 129 PTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGE---DGHIKIADFGVSN 185 Query: 213 ETTSHNS-LTTPCYTPYYVAPEVLGPEK---YDKSCDMWSLGVIMYILLCGYPPFYSNHG 268 E ++ L+ TP ++APE L + K+ D+W++GV +Y + G PF Sbjct: 186 EFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERI 245 Query: 269 LAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 + + ++I+ EFP + +++E++K LI +L P R+ + E HPW+ + Sbjct: 246 MCLH----SKIKSQALEFP--DQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTR 298 >4MYG-A nrPDB Length = 372 Score = 243 bits (621), Expect = 8e-65, Method: Composition-based stats. Identities = 78/353 (22%), Positives = 145/353 (41%), Gaps = 57/353 (16%) Query: 40 PQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD-- 97 + Q K+ ++ K V+ +G G G V +KR+ EK A+K L Sbjct: 27 KGFYKQDVNKTAWELPKT------YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPF 80 Query: 98 -----CPKARREVELHWRASQCPHIVRIVDVYENLYAGRKC--LLIVMECLDGGELFSRI 150 +A RE+ L + Q +++ ++DV+ + R +VM + + + Sbjct: 81 QSEIFAKRAYREL-LLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQ-----TDL 134 Query: 151 QDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGF 210 Q F+E + ++ + + ++Y+HS + HRD+KP NL + LK+ DFG Sbjct: 135 QKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNE---DCELKILDFGL 191 Query: 211 AKETTSHNSLTTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL 269 A+ + +T T +Y APEV+ Y+++ D+WS+G IM +L G F L Sbjct: 192 ARH--ADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYL 249 Query: 270 AISPGMKTRIRMGQYEF-------------------PNPE----WSEVSEEVKMLIRNLL 306 + + EF P + + S + L+ +L Sbjct: 250 DQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKML 309 Query: 307 KTEPTQRMTITEFMNHPWIM-----QSTKVPQTPLHTSRVLKEDKERWEDVKE 354 + + +R+T + + HP+ + Q P S L+ +K ++ K+ Sbjct: 310 ELDVDKRLTAAQALTHPFFEPFRDPEEETEAQQPFDDS--LEHEKLTVDEWKQ 360 >4CSV-A nrPDB Length = 275 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 55/288 (19%), Positives = 119/288 (41%), Gaps = 31/288 (10%) Query: 61 DDYKV------TSQVLGLGINGKVLQIFNKRTQEKFALKMLQD----CPKARREVELHWR 110 D +++ + LG G G+V + + + A+K L++ + +E ++ + Sbjct: 4 DKWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEEFLQEAQIMKK 63 Query: 111 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 + P++V++ V + I+ E + G L ++D + ++ + Sbjct: 64 L-KHPNLVQLYGVC----TKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQV 118 Query: 171 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET--TSHNSLTTPCYTPY 228 + YL S N HRD+ N L N ++K+ DFG A+ + + + Sbjct: 119 ASGMAYLESQNFIHRDLAARNCLVGE---NNVVKVADFGLARLINEDEYTARAGAKFPIK 175 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 + APE + ++ D+W+ G++++ + G P+ G + ++ Y P Sbjct: 176 WTAPEAISYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERG-----YRMP 230 Query: 288 NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTP 335 P+ EE+ L+ P +R T E + H +++ +P+T Sbjct: 231 RPQ--GCPEEIYELMLQCWNKSPEERPTFAETL-HA--LETMFLPETG 273 >1G3N-A nrPDB Length = 326 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 73/302 (24%), Positives = 126/302 (41%), Gaps = 35/302 (11%) Query: 63 YKVTSQVLGLGINGKVLQIFN-KRTQEKFALKMLQDCP-------KARREVEL--HWRAS 112 Y+ ++ +G G GKV + + K ALK ++ REV + H Sbjct: 13 YECVAE-IGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETF 71 Query: 113 QCPHIVRIVDVYENLYAGRK-CLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 + P++VR+ DV R+ L +V E +D +L + + + ++M + Sbjct: 72 EHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLL 130 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVA 231 + +LHS + HRD+KP+N+L TS + +KL DFG A+ + +LT+ T +Y A Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTS---SGQIKLADFGLARIYSFQMALTSVVVTLWYRA 187 Query: 232 PEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE------ 285 PEVL Y D+WS+G I + P F + + + I + E Sbjct: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 Query: 286 -FPNPEWSEVS------------EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVP 332 P + S E K L+ L P +R++ ++HP+ + Sbjct: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCK 307 Query: 333 QT 334 + Sbjct: 308 EN 309 >3PFQ-A nrPDB Length = 674 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 91/408 (22%), Positives = 154/408 (37%), Gaps = 42/408 (10%) Query: 1 MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSG--LQIKKNA 58 +LS +G+ F P PP + + + N Sbjct: 278 LLSQEEGEY----FNVPVPPEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNG 333 Query: 59 IIDDYKVTS----QVLGLGINGKVLQIFNKRTQEKFALKMLQ-DCPKARREVE---LHWR 110 D K+T VLG G GKV+ K T E +A+K+L+ D +VE + R Sbjct: 334 NRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR 393 Query: 111 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 P + + + L VME ++GG+L IQ G F E A I Sbjct: 394 VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG--RFKEPHAVFYAAEI 451 Query: 171 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT-SHNSLTTPCYTPYY 229 + +L S I +RD+K +N++ S+ +K+ DFG KE + T C TP Y Sbjct: 452 AIGLFFLQSKGIIYRDLKLDNVMLDSE---GHIKIADFGMCKENIWDGVTTKTFCGTPDY 508 Query: 230 VAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNP 289 +APE++ + Y KS D W+ GV++Y +L G PF + I +P Sbjct: 509 IAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQS----IMEHNVAYP-- 562 Query: 290 EWSEVSEEVKMLIRNLLKTEPTQRMTI-----TEFMNHPWI---------MQSTKVPQTP 335 +S+E + + L+ P +R+ + H + + + P P Sbjct: 563 --KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKP 620 Query: 336 LHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLL 383 + R + + +T + + +Q + + ++ L Sbjct: 621 KASGRNAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFVNSEFL 668 >3A8W-A nrPDB Length = 345 Score = 242 bits (617), Expect = 3e-64, Method: Composition-based stats. Identities = 76/287 (26%), Positives = 132/287 (45%), Gaps = 34/287 (11%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ--------DCPKARREVELHWRA 111 + D+ + +V+G G KVL + K+T +A+K+++ D + E + +A Sbjct: 8 LQDFDLL-RVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQA 66 Query: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 S P +V + + + L V+E ++GG+L +Q + + E A I Sbjct: 67 SNHPFLVGLH----SCFQTESRLFFVIEYVNGGDLMFHMQRQ--RKLPEEHARFYSAEIS 120 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYYV 230 A+ YLH I +RD+K +N+L S+ +KLTD+G KE ++ +T C TP Y+ Sbjct: 121 LALNYLHERGIIYRDLKLDNVLLDSE---GHIKLTDYGMCKEGLRPGDTTSTFCGTPNYI 177 Query: 231 APEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFY-----SNHGLAISPGMKTRIRMGQYE 285 APE+L E Y S D W+LGV+M+ ++ G PF N + I Q Sbjct: 178 APEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIR 237 Query: 286 FPNPEWSEVSEEVKMLIRNLLKTEPTQRM------TITEFMNHPWIM 326 P +S + ++++ L +P +R+ + HP+ Sbjct: 238 IPR----SLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFR 280 >6BDL-A nrPDB Length = 347 Score = 241 bits (615), Expect = 5e-64, Method: Composition-based stats. Identities = 87/282 (30%), Positives = 136/282 (48%), Gaps = 29/282 (10%) Query: 57 NAIIDDYKVTSQVLGLGINGKVLQIFNK-RTQEKFALKMLQDCPKARREVELHWRAS--- 112 N + D+ + LG+G G+V + K + FA+K+L+ + H R+ Sbjct: 30 NLKLSDFNII-DTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQI 88 Query: 113 ----QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMK 168 IVR+ +++ K L ++ME GGEL++ ++DRG +F + Sbjct: 89 MQGAHSDFIVRLYRTFKDS----KYLYMLMEACLGGELWTILRDRG--SFEDSTTRFYTA 142 Query: 169 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY 228 + EA YLHS I +RD+KPENL+ + KL DFGFAK+ T C TP Sbjct: 143 CVVEAFAYLHSKGIIYRDLKPENLILDHR---GYAKLVDFGFAKKIGFGKKTWTFCGTPE 199 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN 288 YVAPE++ + +D S D WSLG++MY LL G PPF + + I M EFP Sbjct: 200 YVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM--IEFP- 256 Query: 289 PEWSEVSEEVKMLIRNLLKTEPTQRM-----TITEFMNHPWI 325 ++++ LI+ L + P++R+ + + H W Sbjct: 257 ---KKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWF 295 >4AF3-A nrPDB Length = 292 Score = 240 bits (614), Expect = 5e-64, Method: Composition-based stats. Identities = 79/290 (27%), Positives = 138/290 (47%), Gaps = 28/290 (9%) Query: 54 IKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP--------KARREV 105 + ++ IDD+++ + LG G G V K++ ALK+L + RRE+ Sbjct: 16 LTRHFTIDDFEI-GRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREI 74 Query: 106 ELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASE 165 E+ P+I+R+ + + + R+ + +++E GEL+ +Q F E+ + Sbjct: 75 EIQA-HLHHPNILRLYNYFYD----RRRIYLILEYAPRGELYKELQKSC--TFDEQRTAT 127 Query: 166 IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY 225 IM+ + +A+ Y H + HRD+KPEN LK+ DFG++ S T C Sbjct: 128 IMEELADALMYCHGKKVIHRDIKPEN---LLLGLKGELKIADFGWSVHAPSLRR-KTMCG 183 Query: 226 TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE 285 T Y+ PE++ +++ D+W +GV+ Y LL G PPF S RI + Sbjct: 184 TLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESAS----HNETYRRIVKVDLK 239 Query: 286 FPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTP 335 FP + V + LI LL+ P++R+ + + HPW+ +++ P Sbjct: 240 FP----ASVPTGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPP 285 >4UY9-A nrPDB Length = 323 Score = 240 bits (614), Expect = 5e-64, Method: Composition-based stats. Identities = 79/323 (24%), Positives = 134/323 (41%), Gaps = 37/323 (11%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEKFALK---------MLQDCPKARREVELHWRASQCPH 116 +++G+G GKV + F ++ A+K + Q R+E +L + P+ Sbjct: 13 LEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFA-MLKHPN 69 Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 I+ + V L +VME GG L + + I + Y Sbjct: 70 IIALRGVC----LKEPNLCLVMEFARGGPLNRVL---SGKRIPPDILVNWAVQIARGMNY 122 Query: 177 LHSINI---AHRDVKPENLLYTSKRPNA-----ILKLTDFGFAKETTSHNSLTTPCYTPY 228 LH I HRD+K N+L K N ILK+TDFG A+E ++ T Sbjct: 123 LHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMS-AAGTYA 181 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN 288 ++APEV+ + K D+WS GV+++ LL G PF GLA++ G + M + P Sbjct: 182 WMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYG----VAMNKLALPI 237 Query: 289 PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKER 348 P S E L+ + +P R + T ++ ++ + + P + L+++ Sbjct: 238 P--STCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDN--- 292 Query: 349 WEDVKEEMTSALATMRVDYEQIK 371 W+ +EM L + + Sbjct: 293 WKHEIQEMFDQLRAKEKELRTWE 315 >2I0E-A nrPDB Length = 353 Score = 240 bits (613), Expect = 8e-64, Method: Composition-based stats. Identities = 78/289 (26%), Positives = 123/289 (42%), Gaps = 27/289 (9%) Query: 52 LQIKKNAIIDDYKVTS----QVLGLGINGKVLQIFNKRTQEKFALKMLQ-DCPKARREVE 106 + N D K+T VLG G GKV+ K T E +A+K+L+ D +VE Sbjct: 6 SKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVE 65 Query: 107 ---LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREA 163 + R P + + + L VME ++GG+L IQ G F E A Sbjct: 66 CTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG--RFKEPHA 123 Query: 164 SEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT-SHNSLTT 222 I + +L S I +RD+K +N++ S+ +K+ DFG KE + T Sbjct: 124 VFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSE---GHIKIADFGMCKENIWDGVTTKT 180 Query: 223 PCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMG 282 C TP Y+APE++ + Y KS D W+ GV++Y +L G PF + I Sbjct: 181 FCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQS----IMEH 236 Query: 283 QYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTI-----TEFMNHPWIM 326 +P +S+E + + L+ P +R+ + H + Sbjct: 237 NVAYP----KSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFR 281 >5NGU-A nrPDB Length = 381 Score = 240 bits (612), Expect = 9e-64, Method: Composition-based stats. Identities = 74/322 (22%), Positives = 136/322 (42%), Gaps = 44/322 (13%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQ------DCPKARREVELHWRASQCPHIVRIVDV 123 +G G G V ++ + + A+K + C + RE+++ R + +I+ I D+ Sbjct: 50 IGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLR-FRHENIIGINDI 108 Query: 124 YENLYAGR-KCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182 + K + IV + ++ +L+ ++ Q + + I ++Y+HS N+ Sbjct: 109 IRAPTIEQMKDVYIVQDLMET-DLYKLLK---TQHLSNDHICYFLYQILRGLKYIHSANV 164 Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS----LTTPCYTPYYVAPEV-LGP 237 HRD+KP NLL + LK+ DFG A+ + LT T +Y APE+ L Sbjct: 165 LHRDLKPSNLLLNT---TCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNS 221 Query: 238 EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMK--------------TRIRMGQ 283 + Y KS D+WS+G I+ +L P F H L + ++ Sbjct: 222 KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARN 281 Query: 284 YEFPNPEWSEVS---------EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQT 334 Y P ++V + L+ +L P +R+ + + + HP++ Q Sbjct: 282 YLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDE 341 Query: 335 PLHTSRVLKEDKERWEDVKEEM 356 P+ + K D E + KE++ Sbjct: 342 PIAEAP-FKFDMELDDLPKEKL 362 >5J5T-A nrPDB Length = 370 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 73/279 (26%), Positives = 124/279 (44%), Gaps = 29/279 (10%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-----DCPKARREVELHWRASQCP 115 +D+++ + +G G G V + N T E A+K+++ D ++E+ + + + P Sbjct: 4 EDFELIQR-IGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEI-IMMKDCKHP 61 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 +IV Y Y R L I ME GG L G +E + + + + + + Sbjct: 62 NIV----AYFGSYLRRDKLWICMEFCGGGSLQDIYHVTG--PLSELQIAYVSRETLQGLY 115 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSH-NSLTTPCYTPYYVAPEV 234 YLHS HRD+K N+L T N +KL DFG + + T+ TPY++APEV Sbjct: 116 YLHSKGKMHRDIKGANILLTD---NGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEV 172 Query: 235 L---GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNP-- 289 Y++ CD+W++G+ L PP + H M+ M + F P Sbjct: 173 AAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHP------MRALFLMTKSNFQPPKL 226 Query: 290 -EWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 + + S ++ L P +R T + + HP++ Q Sbjct: 227 KDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQ 265 >5VO2-A nrPDB Length = 300 Score = 239 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 78/286 (27%), Positives = 126/286 (44%), Gaps = 23/286 (8%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENL 127 Q +G G G V E+ A+K ++D + + H R + P+I+ V Sbjct: 18 QWVGSGAQGAVFLGRFH--GEEVAVKKVRDLKETDIK---HLRKLKHPNIITFKGVCTQA 72 Query: 128 YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDV 187 C I+ME G+L+ + R + T + I + YLH I HRD+ Sbjct: 73 ----PCYCILMEFCAQGQLYEVL--RAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDL 126 Query: 188 KPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMW 247 K N+L T + ++K++DFG +KE + ++ + T ++APEV+ E + D+W Sbjct: 127 KSPNMLIT---YDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIW 183 Query: 248 SLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLK 307 S GV+++ LL G P+ AI G+ G P S + K+L+R Sbjct: 184 SFGVVLWELLTGEIPYKDVDSSAIIWGV------GSNSLHLPVPSSCPDGFKILLRQCWN 237 Query: 308 TEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVK 353 ++P R + + + H I S V TP T K E E+VK Sbjct: 238 SKPRNRPSFRQILLHLDIA-SADVLSTPQET--YFKSQAEWREEVK 280 >1JNK-A nrPDB Length = 423 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 67/331 (20%), Positives = 130/331 (39%), Gaps = 52/331 (15%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRI 120 + +G G G V ++ A+K L +A RE+ + + +I+ + Sbjct: 68 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL-VLMKCVNHKNIISL 126 Query: 121 VDVY--ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 ++V+ + + + +VME +D L IQ D S ++ + I++LH Sbjct: 127 LNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQMELDH----ERMSYLLYQMLCGIKHLH 181 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPE 238 S I HRD+KP N++ + + LK+ DFG A+ + +T T YY APEV+ Sbjct: 182 SAGIIHRDLKPSNIVV---KSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGM 238 Query: 239 KYDKSCDMWSLGVIMYILLCGYPPFYSNH-----------------------GLAISPGM 275 Y ++ D+WS+G IM ++ F + + Sbjct: 239 GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYV 298 Query: 276 KTRIRMGQYEFPNPEWSEVSE-----------EVKMLIRNLLKTEPTQRMTITEFMNHPW 324 + R + FP + + + L+ +L +P +R+++ + + HP+ Sbjct: 299 ENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPY 358 Query: 325 IMQSTKVPQTPLHTSRVLKEDKERWEDVKEE 355 I + ++ + + E EE Sbjct: 359 INVWYDPAEVEAPPPQIYDKQLDEREHTIEE 389 >3TKU-A nrPDB Length = 433 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 78/338 (23%), Positives = 143/338 (42%), Gaps = 49/338 (14%) Query: 57 NAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARR-------EVELHW 109 +D+++ +V+G G G+V + K T+ +A+K+L +R E Sbjct: 86 QLHREDFEII-KVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVL 144 Query: 110 RASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 169 C I + +++ L +VM+ GG+L + + D+ E A + Sbjct: 145 VNGDCQWITALHYAFQD----ENHLYLVMDYYVGGDLLTLLSKFEDK-LPEDMARFYIGE 199 Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL--TTPCYTP 227 + AI +H ++ HRD+KP+N+L N ++L DFG + ++ + TP Sbjct: 200 MVLAIDSIHQLHYVHRDIKPDNVLLD---VNGHIRLADFGSCLKMNDDGTVQSSVAVGTP 256 Query: 228 YYVAPEVLGPE-----KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMG 282 Y++PE+L KY CD WSLGV MY +L G PFY+ + + Sbjct: 257 DYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH--EE 314 Query: 283 QYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRM---TITEFMNHPWIMQSTKVPQTPLHTS 339 +++FP+ ++VSEE K LI+ L+ + +R+ I +F H + Sbjct: 315 RFQFPS-HVTDVSEEAKDLIQRLICSR-ERRLGQNGIEDFKKHAFF-------------- 358 Query: 340 RVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIED 377 + WE+++ + + + +D Sbjct: 359 -----EGLNWENIRNLEAPYIPDVSSPSDTSNFDVDDD 391 >3ORZ-A nrPDB Length = 316 Score = 239 bits (609), Expect = 3e-63, Method: Composition-based stats. Identities = 81/323 (25%), Positives = 134/323 (41%), Gaps = 39/323 (12%) Query: 24 PTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFN 83 P A P P + +D+K ++LG G V+ Sbjct: 3 MDPEFMDGTAAEPRPGAGSLQHAQPPPQPRK---KRPEDFK-FGKILGEGSFSTVVLARE 58 Query: 84 KRTQEKFALKMLQD--------CPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLL 135 T ++A+K+L+ P RE ++ R P V++ +++ + L Sbjct: 59 LATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL-DHPFFVKLYFCFQD----DEKLY 113 Query: 136 IVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT 195 + GEL I+ G +F E I A++YLH I HRD+KPEN+L Sbjct: 114 FGLSYAKNGELLKYIRKIG--SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN 171 Query: 196 SKRPNAILKLTDFGFAKETTSHNS---LTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVI 252 + +++TDFG AK + + + T YV+PE+L + KS D+W+LG I Sbjct: 172 E---DMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCI 228 Query: 253 MYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQ 312 +Y L+ G PPF + + I +I +Y+FP + + + L+ LL + T+ Sbjct: 229 IYQLVAGLPPFRAGNEYLIFQ----KIIKLEYDFPEKFF----PKARDLVEKLLVLDATK 280 Query: 313 RMTITE------FMNHPWIMQST 329 R+ E HP+ T Sbjct: 281 RLGCEEMEGYGPLKAHPFFESVT 303 >4IC8-A nrPDB Length = 442 Score = 238 bits (608), Expect = 3e-63, Method: Composition-based stats. Identities = 73/357 (20%), Positives = 139/357 (38%), Gaps = 60/357 (16%) Query: 30 HPPAQPPPPPPQQFPQFHVKSGLQIKKNAII------------DDYKVTSQVLGLGINGK 77 PP P + H + + K A++ D+Y++ + +G G G Sbjct: 12 GEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEII-ETIGNGAYGV 70 Query: 78 VLQIFNKRTQEKFALKMLQDC-------PKARREVELHWRASQCPHIVRIVDVYENL--Y 128 V + T ++ A+K + + + RE+++ + + +I+ I D+ Y Sbjct: 71 VSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI-LKHFKHDNIIAIKDILRPTVPY 129 Query: 129 AGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVK 188 K + +V++ ++ +L I Q T + + ++Y+HS + HRD+K Sbjct: 130 GEFKSVYVVLDLMES-DLHQIIHS--SQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLK 186 Query: 189 PENLLYTSKRPNAILKLTDFGFAKET-----TSHNSLTTPCYTPYYVAPE-VLGPEKYDK 242 P NLL N LK+ DFG A+ +T T +Y APE +L +Y + Sbjct: 187 PSNLLVNE---NCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQ 243 Query: 243 SCDMWSLGVIMYILLCGYPPFYSNH--------------------GLAISPGMKTRIRMG 282 + D+WS+G I +L F + + ++ I+ Sbjct: 244 AIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSL 303 Query: 283 QYEFPNPEWSEVSE----EVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTP 335 P P W V + L+ +L+ EP+ R++ + HP++ + P Sbjct: 304 PPRQPVP-WETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEP 359 >3DAK-A nrPDB Length = 290 Score = 238 bits (607), Expect = 4e-63, Method: Composition-based stats. Identities = 71/294 (24%), Positives = 126/294 (42%), Gaps = 40/294 (13%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWRAS---QCP 115 DDY++ +V+G G V + +EK A+K + + C + E+ +A P Sbjct: 10 DDYEL-QEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHP 68 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQ------DRGDQAFTEREASEIMKS 169 +IV Y + + L +VM+ L GG + I+ + E + I++ Sbjct: 69 NIV----SYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILRE 124 Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT------TP 223 + E ++YLH HRDVK N+L + +++ DFG + + +T T Sbjct: 125 VLEGLEYLHKNGQIHRDVKAGNILLGE---DGSVQIADFGVSAFLATGGDITRNKVRKTF 181 Query: 224 CYTPYYVAPEVLGP-EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMG 282 TP ++APEV+ YD D+WS G+ L G P++ P MK + Sbjct: 182 VGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHK------YPPMKVLMLTL 235 Query: 283 QYEFPNPE--------WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328 Q + P+ E + + + +I L+ +P +R T E + H + ++ Sbjct: 236 QNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKA 289 >2XS0-A nrPDB Length = 386 Score = 237 bits (605), Expect = 6e-63, Method: Composition-based stats. Identities = 71/331 (21%), Positives = 135/331 (40%), Gaps = 52/331 (15%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRI 120 + +G G G V ++ + A+K L +A RE+ + + +I+ + Sbjct: 32 KPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYREL-VLMKCVNHKNIIGL 90 Query: 121 VDVY--ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 ++V+ + + + IVME +D L IQ D S ++ + I++LH Sbjct: 91 LNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQMELDH----ERMSYLLYQMLCGIKHLH 145 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPE 238 S I HRD+KP N++ + + LK+ DFG A+ + + T YY APEV+ Sbjct: 146 SAGIIHRDLKPSNIVV---KSDCTLKILDFGLARTAGTSFMMVPFVVTRYYRAPEVILGM 202 Query: 239 KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLA-----------------------ISPGM 275 Y ++ D+WS+G IM ++ G F + + + Sbjct: 203 GYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYV 262 Query: 276 KTRIRMGQYEF----PNPEWSEVSEE-------VKMLIRNLLKTEPTQRMTITEFMNHPW 324 + R + Y F P+ + SE + L+ +L + ++R+++ E + HP+ Sbjct: 263 ENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPY 322 Query: 325 IMQSTKVPQTPLHTSRVLKEDKERWEDVKEE 355 I + ++ + + E EE Sbjct: 323 INVWYDPSEAEAPPPKIPDKQLDEREHTIEE 353 >4QTB-A nrPDB Length = 380 Score = 237 bits (605), Expect = 6e-63, Method: Composition-based stats. Identities = 71/304 (23%), Positives = 130/304 (42%), Gaps = 43/304 (14%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQ------DCPKARREVELHWRASQCPHIVRIV 121 Q +G G G V ++ + + A+K + C + RE+++ R + +++ I Sbjct: 47 QYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLR-FRHENVIGIR 105 Query: 122 DVYE-NLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 D+ + + + IV + ++ +L+ ++ Q + + I ++Y+HS Sbjct: 106 DILRASTLEAMRDVYIVQDLMET-DLYKLLKS---QQLSNDHICYFLYQILRGLKYIHSA 161 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAK----ETTSHNSLTTPCYTPYYVAPEV-L 235 N+ HRD+KP NLL + LK+ DFG A+ E LT T +Y APE+ L Sbjct: 162 NVLHRDLKPSNLLINT---TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIML 218 Query: 236 GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMK--------------TRIRM 281 + Y KS D+WS+G I+ +L P F H L + ++ Sbjct: 219 NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKA 278 Query: 282 GQYEFPNPEWSEVS---------EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVP 332 Y P ++V+ + L+ +L P +R+T+ E + HP++ Q Sbjct: 279 RNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPT 338 Query: 333 QTPL 336 P+ Sbjct: 339 DEPV 342 >4EWQ-A nrPDB Length = 383 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 72/334 (21%), Positives = 134/334 (40%), Gaps = 49/334 (14%) Query: 39 PPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-- 96 P + Q K+ ++ + Y+ S V G G G V F+ +T + A+K L Sbjct: 28 RPTFYRQELNKTIWEVP-----ERYQNLSPV-GSGAYGSVCAAFDTKTGLRVAVKKLSRP 81 Query: 97 -----DCPKARREVELHWRASQCPHIVRIVDVYE--NLYAGRKCLLIVMECLDGGELFSR 149 + RE+ L + + +++ ++DV+ + +V + G +L + Sbjct: 82 FQSIIHAKRTYRELRL-LKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNI 139 Query: 150 IQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFG 209 ++ Q T+ ++ I ++Y+HS +I HRD+KP NL + LK+ DFG Sbjct: 140 VK---CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE---DCELKILDFG 193 Query: 210 FAKETTSHNSLTTPCYTPYYVAPEV-LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHG 268 A+ T + +T T +Y APE+ L Y+++ D+WS+G IM LL G F Sbjct: 194 LARHT--DDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDH 251 Query: 269 LAISPGMKTRIRMGQYE-------------------FPNPEWSEV----SEEVKMLIRNL 305 + + + E P ++ V + L+ + Sbjct: 252 IDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKM 311 Query: 306 LKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTS 339 L + +R+T + + H + Q P+ Sbjct: 312 LVLDSDKRITAAQALAHAYFAQYHDPDDEPVADP 345 >6HXF-B nrPDB Length = 302 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 75/299 (25%), Positives = 134/299 (44%), Gaps = 26/299 (8%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARRE---VELHWRAS-QCPH 116 + +++ + LG G GKV + NK T A K+++ + E VE+ A+ P+ Sbjct: 19 EVWEIVGE-LGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPY 77 Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 IV+++ Y + L I++E GG + I D+ TE + + + + EA+ + Sbjct: 78 IVKLLGAYYH----DGKLWIMIEFCPGGAV-DAIMLELDRGLTEPQIQVVCRQMLEALNF 132 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGF-AKETTSHNSLTTPCYTPYYVAPEVL 235 LHS I HRD+K N+L T + ++L DFG AK + + TPY++APEV+ Sbjct: 133 LHSKRIIHRDLKAGNVLMTLE---GDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVV 189 Query: 236 G-----PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE 290 YD D+WSLG+ + + PP + + M+ +++ + + P Sbjct: 190 MCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNP------MRVLLKIAKSDPPTLL 243 Query: 291 WS-EVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKER 348 + S E + ++ L P R + + + HP++ T + E E Sbjct: 244 TPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEE 302 >4BBM-A nrPDB Length = 331 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 69/318 (21%), Positives = 132/318 (41%), Gaps = 43/318 (13%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC-------PKARREVELHWRAS 112 ++ Y+ ++G G G V++ NK T A+K + A RE++L + Sbjct: 24 MEKYENLG-LVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKL-LKQL 81 Query: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 + ++V +++V +K +V E +D L + + + + I Sbjct: 82 RHENLVNLLEVC----KKKKRWYLVFEFVDHTILDDL--ELFPNGLDYQVVQKYLFQIIN 135 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET-TSHNSLTTPCYTPYYVA 231 I + HS NI HRD+KPEN+L + + ++KL DFGFA+ T +Y A Sbjct: 136 GIGFCHSHNIIHRDIKPENILVS---QSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRA 192 Query: 232 PEVLGPE-KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLA-------------------- 270 PE+L + KY K+ D+W++G ++ + G P F + + Sbjct: 193 PELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELF 252 Query: 271 ISPGMKTRIRMGQYEFPNP---EWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 + +R+ + + P + ++SE V L + L +P +R E ++H + Sbjct: 253 NKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQM 312 Query: 328 STKVPQTPLHTSRVLKED 345 + +++D Sbjct: 313 DGFAERFSQELQLKVQKD 330 >6GU6-A nrPDB Length = 302 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 71/298 (23%), Positives = 125/298 (41%), Gaps = 43/298 (14%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK-------ARREVELHWRAS 112 ++DY + +G G G V + +K T + A+K ++ + A RE+ L + Sbjct: 6 MEDYTKIEK-IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISL-LKEL 63 Query: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQD-RGDQAFTEREASEIMKSIG 171 + P+IV + DV L ++ E L +L + Q + I Sbjct: 64 RHPNIVSLQDVL----MQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQIL 118 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT-SHNSLTTPCYTPYYV 230 + I + HS + HRD+KP+NLL K +KL DFG A+ T T +Y Sbjct: 119 QGIVFCHSRRVLHRDLKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHEVVTLWYR 175 Query: 231 APEVLGPE-KYDKSCDMWSLGVIMYILLCGYPPFYSNHGL---------------AISPG 274 +PEVL +Y D+WS+G I L P F+ + + + P Sbjct: 176 SPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPE 235 Query: 275 MKTRIRMGQYEFPNPEWSEVSEEVK-------MLIRNLLKTEPTQRMTITEFMNHPWI 325 +++ ++ + FP + ++ VK L+ +L +P +R++ +NHP+ Sbjct: 236 VES-LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 292 >4AW2-A nrPDB Length = 437 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 74/282 (26%), Positives = 129/282 (45%), Gaps = 30/282 (10%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARR-------EVELHWRASQ 113 +D+++ +V+G G G+V + K + FA+K+L +R E Sbjct: 74 EDFEIL-KVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGD 132 Query: 114 CPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEA 173 I + +++ L +VM+ GG+L + + D+ E A + + A Sbjct: 133 SKWITTLHYAFQD----DNNLYLVMDYYVGGDLLTLLSKFEDR-LPEEMARFYLAEMVIA 187 Query: 174 IQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL--TTPCYTPYYVA 231 I +H ++ HRD+KP+N+L N ++L DFG + ++ + TP Y++ Sbjct: 188 IDSVHQLHYVHRDIKPDNILMD---MNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYIS 244 Query: 232 PEVLG-----PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286 PE+L +Y CD WSLGV MY +L G PFY+ + + +++F Sbjct: 245 PEILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH--KERFQF 302 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRM---TITEFMNHPWI 325 P + ++VSE K LIR L+ + R+ I +F HP+ Sbjct: 303 PT-QVTDVSENAKDLIRRLICSR-EHRLGQNGIEDFKKHPFF 342 >4APC-A nrPDB Length = 350 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 70/287 (24%), Positives = 129/287 (44%), Gaps = 23/287 (8%) Query: 64 KVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQCPH 116 V Q +G G GK + + + ++ +K + ++ ++RREV + + P+ Sbjct: 26 YVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLAN-MKHPN 84 Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 IV+ Y + L IVM+ +GG+LF RI + F E + + I A+++ Sbjct: 85 IVQ----YRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKH 140 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPC-YTPYYVAPEVL 235 +H I HRD+K +N+ T + ++L DFG A+ S L C TPYY++PE+ Sbjct: 141 VHDRKILHRDIKSQNIFLT---KDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEIC 197 Query: 236 GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 295 + Y+ D+W+LG ++Y L F + + +I G + P S Sbjct: 198 ENKPYNNKSDIWALGCVLYELCTLKHAFEAGSM----KNLVLKIISGSF---PPVSLHYS 250 Query: 296 EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVL 342 +++ L+ L K P R ++ + +I + + +P + Sbjct: 251 YDLRSLVSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEF 297 >3C51-A nrPDB Length = 543 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 83/385 (21%), Positives = 157/385 (40%), Gaps = 36/385 (9%) Query: 12 VPFPAPAPPPQPPTPALPHPPAQPPPPP---PQQFPQFHVKSGLQIKKNAIIDDYKVTSQ 68 A QP A+ Q P F +F L+ + + +D+ + + Sbjct: 134 ARAGAGDGLFQPLLRAVLAHLGQAPFQEFLDSLYFLRFLQWKWLEAQ--PMGEDWFLDFR 191 Query: 69 VLGLGINGKVLQIFNKRTQEKFALKMLQDC--------PKARREVELHWRASQCPHIVRI 120 VLG G G+V K T + +A K L A E ++ + IV + Sbjct: 192 VLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKV-HSRFIVSL 250 Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRI--QDRGDQAFTEREASEIMKSIGEAIQYLH 178 +E + L +VM ++GG++ I D + F E A I +++LH Sbjct: 251 AYAFET----KTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLH 306 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TPCYTPYYVAPEVLGP 237 NI +RD+KPEN+L + ++++D G A E + + T TP ++APE+L Sbjct: 307 QRNIIYRDLKPENVLLDD---DGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLG 363 Query: 238 EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEE 297 E+YD S D ++LGV +Y ++ PF + + +K R+ +P+ + S Sbjct: 364 EEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPD----KFSPA 419 Query: 298 VKMLIRNLLKTEPTQRMTITE-----FMNHPWIMQST-KVPQTPLHTSRVLKEDKERWED 351 K LL+ +P +R+ + HP + + + + T + + + + Sbjct: 420 SKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDSRTVYAK 479 Query: 352 VKEEM--TSALATMRVDYEQIKIKK 374 +++ S + + + + + Sbjct: 480 NIQDVGAFSTVKGVAFEKADTEFFQ 504 >6QAU-A nrPDB Length = 280 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 78/283 (27%), Positives = 135/283 (47%), Gaps = 26/283 (9%) Query: 59 IIDDYKVTSQVL-GLGINGKVLQIFNK-RTQEKFALKMLQDCPKAR------REVELHWR 110 ++ D++ + + L G G V + ++ +T + A+K + ++ +E+++ + Sbjct: 7 VVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKI-LK 65 Query: 111 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 Q +IV + DV E + +VME +GG+L +Q +G +E + I Sbjct: 66 ELQHENIVALYDVQE----LPNSVFLVMEYCNGGDLADYLQAKG--TLSEDTIRVFLHQI 119 Query: 171 GEAIQYLHSINIAHRDVKPENLLYT------SKRPNAILKLTDFGFAKETTSHNSLTTPC 224 A++ LHS I HRD+KP+N+L + S +K+ DFGFA+ S+ C Sbjct: 120 AAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLC 179 Query: 225 YTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQY 284 +P Y+APEV+ + YD D+WS+G ++Y L G PPF +N + + R Sbjct: 180 GSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLR-MFYEKNRSLMP 238 Query: 285 EFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 P E S + L+ LL+ RM F +HP++ Q Sbjct: 239 SIPR----ETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQ 277 >2F9G-A nrPDB Length = 353 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 79/344 (22%), Positives = 138/344 (40%), Gaps = 54/344 (15%) Query: 59 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ--DCP----KARREVELHWRAS 112 I D+++ S +LG G G V +K T E A+K ++ D P + RE+++ + Sbjct: 9 ISSDFQLKS-LLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKI-LKHF 66 Query: 113 QCPHIVRIVDVYE-NLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 + +I+ I ++ + + + I+ E + +L I Q ++ + Sbjct: 67 KHENIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVI---STQMLSDDHIQYFIYQTL 122 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS-----------HNSL 220 A++ LH N+ HRD+KP NLL S N LK+ DFG A+ + + Sbjct: 123 RAVKVLHGSNVIHRDLKPSNLLINS---NCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179 Query: 221 TTPCYTPYYVAPEV-LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH------------ 267 T T +Y APEV L KY ++ D+WS G I+ L P F Sbjct: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 Query: 268 ---------GLAISPGMKTRIRMGQYEFPNP---EWSEVSEEVKMLIRNLLKTEPTQRMT 315 SP + I+ P + V+ + L++ +L +P +R+T Sbjct: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 Query: 316 ITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSA 359 E + HP++ P + ++ KE +T+ Sbjct: 300 AKEALEHPYLQTYHDPNDEPEGEP--IPPSFFEFDHYKEALTTK 341 >4U41-A nrPDB Length = 332 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 65/306 (21%), Positives = 130/306 (42%), Gaps = 22/306 (7%) Query: 63 YKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ----DCPKARREVELHWRASQCPHIV 118 +++ +V+G G G+V + + +T + A+K++ + + + E+ + + S +I Sbjct: 26 FELV-EVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIA 84 Query: 119 RIVDVY--ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 + ++ L +VME G + +++ E + I + I + + Sbjct: 85 TYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAH 144 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSH-NSLTTPCYTPYYVAPEVL 235 LH ++ HRD+K +N+L T NA +KL DFG + + T TPY++APEV+ Sbjct: 145 LHIHHVIHRDIKGQNVLLTE---NAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVI 201 Query: 236 GPEK-----YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE 290 ++ YD D+WS G+ + G PP H M+ + + P + Sbjct: 202 ACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHP------MRALFLIPRNPPPRLK 255 Query: 291 WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE 350 + S++ I L QR + + + HP+I Q + + +++ Sbjct: 256 SKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRG 315 Query: 351 DVKEEM 356 + E Sbjct: 316 EKDETE 321 >3OHT-A nrPDB Length = 389 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 77/371 (20%), Positives = 149/371 (40%), Gaps = 54/371 (14%) Query: 39 PPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-- 96 P + Q K+ ++ + Y+ S V G G G V ++ ++ K A+K L Sbjct: 34 RPTFYRQELNKTIWEVP-----ERYQTLSPV-GSGAYGSVCSSYDVKSGLKIAVKKLSRP 87 Query: 97 -----DCPKARREVELHWRASQCPHIVRIVDVYE--NLYAGRKCLLIVMECLDGGELFSR 149 + RE+ L + + +++ ++DV+ + +V + G +L + Sbjct: 88 FQSIIHAKRTYRELRL-LKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLM-GADLNNI 145 Query: 150 IQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFG 209 ++ Q T+ ++ I ++Y+HS +I HRD+KP NL + LK+ DFG Sbjct: 146 VK---CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE---DCELKILDFG 199 Query: 210 FAKETTSHNSLTTPCYTPYYVAPEV-LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHG 268 A+ T + +T T +Y APE+ L Y+ + D+WS+G IM LL G F Sbjct: 200 LARHT--DDEMTGYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDH 257 Query: 269 LAISPGMKTRIRMGQ-------------------YEFPNPEWSEV----SEEVKMLIRNL 305 + + + P +++V + L+ + Sbjct: 258 INQLQQIMRLTGTPPASVISRMPSHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKM 317 Query: 306 LKTEPTQRMTITEFMNHPWIMQSTKVPQTPLH-----TSRVLKEDKERWEDVKEEMTSAL 360 L + +R+T +E + HP+ Q P + + + E W+ + E + Sbjct: 318 LVLDTDKRITASEALAHPYFSQYHDPDDEPESEPYDQSFESRQLEIEEWKRLTYEEVCSF 377 Query: 361 ATMRVDYEQIK 371 T D ++++ Sbjct: 378 ETPPFDGDEME 388 >3OZ6-A nrPDB Length = 388 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 72/349 (20%), Positives = 136/349 (38%), Gaps = 79/349 (22%) Query: 56 KNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELH 108 ++ Y++ + LG G G V + ++RT E A+K + D + RE+ + Sbjct: 4 DRHVLRKYELVKK-LGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMIL 62 Query: 109 WRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMK 168 S +IV +++V + + +V + ++ +L + I+ ++ Sbjct: 63 TELSGHENIVNLLNVLRA--DNDRDVYLVFDYMET-DLHAVIRA---NILEPVHKQYVVY 116 Query: 169 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET-------------- 214 + + I+YLHS + HRD+KP N+L ++ +K+ DFG ++ Sbjct: 117 QLIKVIKYLHSGGLLHRDMKPSNILLNAE---CHVKVADFGLSRSFVNIRRVTNNIPLSI 173 Query: 215 --------TSHNSLTTPCYTPYYVAPEVLGP-EKYDKSCDMWSLGVIMYILLCGYPPFYS 265 LT T +Y APE+L KY K DMWSLG I+ +LCG P F Sbjct: 174 NENTENFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPG 233 Query: 266 NHGL---------------------------AISPGMKTRIRMGQYE------------F 286 + + + +K ++ + Q Sbjct: 234 SSTMNQLERIIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLL 293 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTP 335 ++ +EE L+ LL+ P +R++ + + HP++ + P Sbjct: 294 KINPKADCNEEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEP 342 >4WNO-A nrPDB Length = 287 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 70/272 (25%), Positives = 128/272 (47%), Gaps = 25/272 (9%) Query: 67 SQVLGLGINGKVLQIFNKRTQE-KFALKMLQDCPKAR------REVELHWRASQCPHIVR 119 ++G G V + ++ + + A+K + A+ +E+++ + + +IV Sbjct: 23 KDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKI-LKELKHENIVA 81 Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 + D E + +VME +GG+L + + +E ++ I A++ LHS Sbjct: 82 LYDFQEMA----NSVYLVMEYCNGGDLADYLHAM--RTLSEDTIRLFLQQIAGAMRLLHS 135 Query: 180 INIAHRDVKPENLLYTSKR------PNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPE 233 I HRD+KP+N+L ++ + +K+ DFGFA+ S+ T C +P Y+APE Sbjct: 136 KGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPE 195 Query: 234 VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSE 293 V+ + YD D+WS+G I+Y L G PF ++ + + + P E Sbjct: 196 VIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLR-LFYEKNKTLVPTIPR----E 250 Query: 294 VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 S ++ L+ LL+ RM EF +HP++ Sbjct: 251 TSAPLRQLLLALLQRNHKDRMDFDEFFHHPFL 282 >2WQN-A nrPDB Length = 310 Score = 232 bits (593), Expect = 2e-61, Method: Composition-based stats. Identities = 67/306 (21%), Positives = 123/306 (40%), Gaps = 41/306 (13%) Query: 23 PPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIF 82 PP P A P F ++ + +G G +V + Sbjct: 11 PPVPQFQPQKALRPDMGYNTLANFRIE------------------KKIGRGQFSEVYRAA 52 Query: 83 NKRTQEKFALKML--------QDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCL 134 ALK + + +E++L + P++++ Y + L Sbjct: 53 CLLDGVPVALKKVQIFDLMDAKARADCIKEIDL-LKQLNHPNVIK----YYASFIEDNEL 107 Query: 135 LIVMECLDGGELFSRIQ--DRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENL 192 IV+E D G+L I+ + + ER + + A++++HS + HRD+KP N+ Sbjct: 108 NIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANV 167 Query: 193 LYTSKRPNAILKLTDFGFAKETTS-HNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV 251 T+ ++KL D G + +S + + TPYY++PE + Y+ D+WSLG Sbjct: 168 FITA---TGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGC 224 Query: 252 IMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPT 311 ++Y + PFY + + +I Y P SEE++ L+ + +P Sbjct: 225 LLYEMAALQSPFYGDKM--NLYSLCKKIEQCDY--PPLPSDHYSEELRQLVNMCINPDPE 280 Query: 312 QRMTIT 317 +R +T Sbjct: 281 KRPDVT 286 >4YHJ-A nrPDB Length = 584 Score = 232 bits (593), Expect = 2e-61, Method: Composition-based stats. Identities = 75/304 (24%), Positives = 125/304 (41%), Gaps = 27/304 (8%) Query: 37 PPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ 96 F QF L+ + + + +VLG G G+V + T + +A K LQ Sbjct: 162 YQESSYFSQFLQWKWLE--RQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQ 219 Query: 97 DC--------PKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFS 148 A E + + Q +V + YE + L +V+ ++GG+L Sbjct: 220 KKRIKKRKGEAMALNEKRILEKV-QSRFVVSLAYAYET----KDALCLVLTIMNGGDLKF 274 Query: 149 RIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDF 208 I + G+ F E+ A + ++ L I +RD+KPEN+L + ++++D Sbjct: 275 HIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDR---GHIRISDL 331 Query: 209 GFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHG 268 G A E + T Y+APEV+ EKY S D W LG ++Y ++ G+ PF Sbjct: 332 GLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKE 391 Query: 269 LAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRM-----TITEFMNHP 323 + RI+ E+ + SE+ K + R LL P++R+ HP Sbjct: 392 KVKWEEVDQRIKNDTEEYSE----KFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHP 447 Query: 324 WIMQ 327 Sbjct: 448 VFKD 451 >4QNY-A nrPDB Length = 354 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 70/312 (22%), Positives = 122/312 (39%), Gaps = 42/312 (13%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFN-KRTQEKFALKMLQD--------CPKARREVELHWR 110 +DD + +++G G G V++ + K A+K + + RE++L Sbjct: 18 LDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLA- 76 Query: 111 ASQCPHIVRIVDVYENLYAGR-KCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 169 +I+ + ++ IVM+ ++ +L + R Q TE + Sbjct: 77 HFNDDNIIGLRNILTPEDPENFDHFYIVMDIMET-DLKQVL--RSGQELTEAHIQFFIYQ 133 Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT-PY 228 A+ +HS + HRD+ P N+L + N LK+ DFG AKE T T + Sbjct: 134 ALRALHIIHSAGVIHRDITPANILVNT---NCDLKICDFGLAKEENDQGEYMTDYVTMRW 190 Query: 229 YVAPE-VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL------------------ 269 Y APE V+ + Y D+W +G I+ LL P F + Sbjct: 191 YRAPELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDI 250 Query: 270 -AISPGMKTRIRMGQYEFPNPEW----SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPW 324 ++ + + P +W S E L+R++L P +R+T+ + M HP+ Sbjct: 251 NSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHPF 310 Query: 325 IMQSTKVPQTPL 336 + Q L Sbjct: 311 LEQLHDDADDNL 322 >5AIR-A nrPDB Length = 430 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 81/299 (27%), Positives = 131/299 (43%), Gaps = 30/299 (10%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFAL-KMLQDCPKARREVELHWRASQCPHIVRIVDVYEN 126 +V+G G G V Q + E A+ K+LQD RE+++ + C +IVR+ + + Sbjct: 70 KVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHC-NIVRLRYFFYS 128 Query: 127 LYAGRKCLL--IVMECLDGGELF-SRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIA 183 + + +V++ + +R R Q M + ++ Y+HS I Sbjct: 129 SGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGIC 188 Query: 184 HRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GPEKYDK 242 HRD+KP+NLL A+LKL DFG AK+ + + YY APE++ G Y Sbjct: 189 HRDIKPQNLLLD--PDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTS 246 Query: 243 SCDMWSLGVIMYILLCGYPPFYSNHGLA--------ISPGMKTRIRM-----GQYEFPNP 289 S D+WS G ++ LL G P F + G+ + + +IR +++FP Sbjct: 247 SIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQI 306 Query: 290 E---WSEV-----SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSR 340 + W++V E L LL+ PT R+T E H + + P L R Sbjct: 307 KAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF-DELRDPNVKLPNGR 364 >3FI2-A nrPDB Length = 353 Score = 232 bits (591), Expect = 3e-61, Method: Composition-based stats. Identities = 64/301 (21%), Positives = 122/301 (40%), Gaps = 52/301 (17%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRI 120 + +G G G V ++ A+K L +A RE+ + + +I+ + Sbjct: 30 KPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYREL-VLMKCVNHKNIISL 88 Query: 121 VDVY--ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 ++V+ + + + +VME +D L IQ D S ++ + I++LH Sbjct: 89 LNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQMELDH----ERMSYLLYQMLCGIKHLH 143 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPE 238 S I HRD+KP N++ + + LK+ DFG A+ + +T T YY APEV+ Sbjct: 144 SAGIIHRDLKPSNIVV---KSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGM 200 Query: 239 KYDKSCDMWSLGVIMYILLCGYPPFYSNH-----------------------GLAISPGM 275 Y ++ D+WS+G IM ++ F + + Sbjct: 201 GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYV 260 Query: 276 KTRIRMGQYEFPNPEWSEVSE-----------EVKMLIRNLLKTEPTQRMTITEFMNHPW 324 + R + FP + + + L+ +L +P +R+++ + + HP+ Sbjct: 261 ENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPY 320 Query: 325 I 325 I Sbjct: 321 I 321 >4ZSG-A nrPDB Length = 347 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 67/316 (21%), Positives = 129/316 (40%), Gaps = 48/316 (15%) Query: 59 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC-------PKARREVELHWRA 111 + D+Y++ + +G G G V + T ++ A+K + + + RE+++ + Sbjct: 5 VGDEYEII-ETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKI-LKH 62 Query: 112 SQCPHIVRIVDVYENL--YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 169 + +I+ I D+ Y K + +V++ ++ +L I Q T + Sbjct: 63 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMES-DLHQIIHS--SQPLTLEHVRYFLYQ 119 Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET-----TSHNSLTTPC 224 + ++Y+HS + HRD+KP NLL N LK+ DFG A+ +T Sbjct: 120 LLRGLKYMHSAQVIHRDLKPSNLLVNE---NCELKIGDFGMARGLCTSPAEHQYFMTEYV 176 Query: 225 YTPYYVAPE-VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH---------------- 267 T +Y APE +L +Y ++ D+WS+G I +L F + Sbjct: 177 ATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPS 236 Query: 268 ----GLAISPGMKTRIRMGQYEFPNPEWSEVSE----EVKMLIRNLLKTEPTQRMTITEF 319 + ++ I+ P P W V + L+ +L+ EP+ R++ Sbjct: 237 PAVIQAVGAERVRAYIQSLPPRQPVP-WETVYPGADRQALSLLGRMLRFEPSARISAAAA 295 Query: 320 MNHPWIMQSTKVPQTP 335 + HP++ + P Sbjct: 296 LRHPFLAKYHDPDDEP 311 >6CCF-A nrPDB Length = 290 Score = 231 bits (589), Expect = 5e-61, Method: Composition-based stats. Identities = 72/303 (23%), Positives = 136/303 (44%), Gaps = 51/303 (16%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFAL--------------------------- 92 ++ YK+ S+ +G G G V +N+ +A+ Sbjct: 4 LNQYKLQSE-IGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQ 62 Query: 93 ----KMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFS 148 K L + +E+ + + ++V++++V ++ L +V + L G + Sbjct: 63 GGPAKQLLPLERVYQEIAILKKL-DHVNVVKLIEVLDD--PAEDNLYLVFDLLRKGPVME 119 Query: 149 RIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDF 208 D+ F+E +A ++ + ++YLH I HRD+KP NLL + +K+ DF Sbjct: 120 V---PCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGD---DGHVKIADF 173 Query: 209 GFAKETTSHNS-LTTPCYTPYYVAPEVLGPEK---YDKSCDMWSLGVIMYILLCGYPPFY 264 G + + +++ L++ TP ++APE + K+ D+W+ GV +Y + G PF Sbjct: 174 GVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFI 233 Query: 265 SNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPW 324 + LA+ +I+ FP E E+SEE+K LI +L P R+ + + HPW Sbjct: 234 DDFILALH----RKIKNEPVVFP--EEPEISEELKDLILKMLDKNPETRIGVPDIKLHPW 287 Query: 325 IMQ 327 + + Sbjct: 288 VTK 290 >6E2O-A nrPDB Length = 295 Score = 230 bits (588), Expect = 6e-61, Method: Composition-based stats. Identities = 73/275 (26%), Positives = 126/275 (45%), Gaps = 21/275 (7%) Query: 69 VLGLGINGKVLQIFNKRTQEKFALKMLQDCPK-----ARREVELHWRASQCPHIVRIVDV 123 VLG G G V + Q + A+K + + E+ LH + + +IV+ + Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALH-KHLKHKNIVQYLGS 87 Query: 124 YENLYAGRKCLLIVMECLDGGELFSRIQDR-GDQAFTEREASEIMKSIGEAIQYLHSINI 182 + + + I ME + GG L + ++ + G E+ K I E ++YLH I Sbjct: 88 F----SENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQI 143 Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TPCYTPYYVAPEVL--GPEK 239 HRD+K +N+L + + +LK++DFG +K N T T T Y+APE++ GP Sbjct: 144 VHRDIKGDNVLINTY--SGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRG 201 Query: 240 YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVK 299 Y K+ D+WSLG + + G PPFY + ++G ++ +S E K Sbjct: 202 YGKAADIWSLGCTIIEMATGKPPFY-----ELGEPQAAMFKVGMFKVHPEIPESMSAEAK 256 Query: 300 MLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQT 334 I + +P +R + + ++ S+K +T Sbjct: 257 AFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKT 291 >3ZDU-A nrPDB Length = 325 Score = 230 bits (587), Expect = 7e-61, Method: Composition-based stats. Identities = 73/319 (22%), Positives = 143/319 (44%), Gaps = 43/319 (13%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK------ARREVELHWRASQ 113 ++ Y+ +V G G G V++ +K T + A+K+ + P+ A RE++ + Sbjct: 2 MEMYETLGKV-GEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKF-LKQFH 59 Query: 114 CPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEA 173 ++V +++V+ +K + +V E +D L + + + I A Sbjct: 60 HENLVNLIEVFRQ----KKKIHLVFEFIDHTVLDEL--QHYCHGLESKRLRKYLFQILRA 113 Query: 174 IQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET-TSHNSLTTPCYTPYYVAP 232 I YLHS NI HRD+KPEN+L + + I KL DFGFA+ + T +Y AP Sbjct: 114 IDYLHSNNIIHRDIKPENILVS---QSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAP 170 Query: 233 E-VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAI-------------------- 271 E VL Y K D+W+LG ++ + G P S+ L + Sbjct: 171 ELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFS 230 Query: 272 SPGMKTRIRMGQYEFP---NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328 + + + Q + P ++ +++ + ++ L+ +P R++ ++ ++H + + Sbjct: 231 KSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRD 290 Query: 329 TKVPQ-TPLHTSRVLKEDK 346 + + P +++L+E K Sbjct: 291 GFIEKFMPELKAKLLQEAK 309 >5LOH-A nrPDB Length = 341 Score = 230 bits (587), Expect = 8e-61, Method: Composition-based stats. Identities = 80/318 (25%), Positives = 141/318 (44%), Gaps = 40/318 (12%) Query: 31 PPAQPPPPPPQQFPQ--FHVKSGLQ---IKKNAIIDDYKVTSQVLGLGINGKVLQIFNKR 85 P P ++ P + G+ + K I+++ + + + G GKV + Sbjct: 1 GPHMDPTAGSKKEPGGGAATEEGVNRIAVPKPPSIEEFSIV-KPISRGAFGKVYLGQ--K 57 Query: 86 TQEKFALKMLQDCPKARR--------EVELHWRASQCPHIVRIVDVYENLYAGRKCLLIV 137 + +A+K+++ + E + S+ P IV + ++ + +V Sbjct: 58 GGKLYAVKVVKKADMINKNMTHQVQAERDALA-LSKSPFIVHLYYSLQSA----NNVYLV 112 Query: 138 MECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSK 197 ME L GG++ S + G F E A + + + A+ YLH I HRD+KP+N+L +++ Sbjct: 113 MEYLIGGDVKSLLHIYG--YFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNE 170 Query: 198 RPNAILKLTDFGFAKETTSHN-------SLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLG 250 +KLTDFG +K T + + + T C TP Y+APE+L + + D W+LG Sbjct: 171 ---GHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPELLLGRAHGPAVDWWALG 227 Query: 251 VIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSE-VSEEVKMLIRNLLKTE 309 V ++ L G PPF + + R + P PE E +S+ + + LL + Sbjct: 228 VCLFEFLTGIPPFNDETPQQVFQNILKR------DIPWPEGEEKLSDNAQSAVEILLTID 281 Query: 310 PTQRMTITEFMNHPWIMQ 327 T+R + E HP Sbjct: 282 DTKRAGMKELKRHPLFSD 299 >4KRC-A nrPDB Length = 317 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 70/301 (23%), Positives = 123/301 (40%), Gaps = 47/301 (15%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK------ARREVELHWRASQCPHIVRIV 121 + LG G V + NK T ALK ++ + A RE+ L + + +IVR+ Sbjct: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLM-KELKHENIVRLY 69 Query: 122 DVYENLYAGRKCLLIVMECLDGGELFSRIQDRG----DQAFTEREASEIMKSIGEAIQYL 177 DV L +V E +D +L + R + + + + + Sbjct: 70 DVIHT----ENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 Query: 178 HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT-SHNSLTTPCYTPYYVAPEVLG 236 H I HRD+KP+NLL + LKL DFG A+ N+ ++ T +Y AP+VL Sbjct: 125 HENKILHRDLKPQNLLINKR---GQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLM 181 Query: 237 PEK-YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRI------------RMGQ 283 + Y S D+WS G I+ ++ G P F + + + ++ + Sbjct: 182 GSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 Query: 284 Y-----EFPNPEWSEV----SEE-----VKMLIRNLLKTEPTQRMTITEFMNHPWIMQST 329 Y + P + +V ++E + + LL+ P R++ + ++HPW + Sbjct: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYY 301 Query: 330 K 330 Sbjct: 302 H 302 >5ZTN-A nrPDB Length = 429 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 80/347 (23%), Positives = 137/347 (39%), Gaps = 63/347 (18%) Query: 50 SGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARR----EV 105 S +Q+ + + Y+V +V+G G G+V++ ++ + + ALKM+++ + R E+ Sbjct: 86 SYVQVPHDHVAYRYEVL-KVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEI 144 Query: 106 EL--HWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREA 163 + H R + + ++ + EN + R + + E L L+ I+ Q F+ Sbjct: 145 RILEHLRKQDKDNTMNVIHMLEN-FTFRNHICMTFELLSM-NLYELIKKNKFQGFSLPLV 202 Query: 164 SEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTP 223 + SI + + LH I H D+KPEN+L + + +K+ DFG + H + T Sbjct: 203 RKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSG-IKVIDFGSSC--YEHQRVYTY 259 Query: 224 CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRI---- 279 + +Y APEV+ +Y DMWSLG I+ LL GYP M + Sbjct: 260 IQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPS 319 Query: 280 ----------------------------------------RMGQYEFPNP--EWSEV--- 294 R G+ P EW Sbjct: 320 QKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKG 379 Query: 295 --SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTS 339 ++ L+ +P RMT + + HPW+ + P T TS Sbjct: 380 CDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKTS 426 >4NST-A nrPDB Length = 351 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 74/306 (24%), Positives = 131/306 (42%), Gaps = 45/306 (14%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-DCPK------ARREVELHWRAS 112 +D + + ++G G G+V + +K T E ALK ++ D K A RE+++ R Sbjct: 12 VDKFDIIG-IIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKI-LRQL 69 Query: 113 QCPHIVRIVDVYEN------LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 +V + ++ + + +V E +D +L ++ G F+E Sbjct: 70 IHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDH-DLMGLLES-GLVHFSEDHIKSF 127 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--LTTPC 224 MK + E ++Y H N HRD+K N+L + + +KL DFG A+ S S T Sbjct: 128 MKQLMEGLEYCHKKNFLHRDIKCSNILLNN---SGQIKLADFGLARLYNSEESRPYTNKV 184 Query: 225 YTPYYVAPE-VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTR----- 278 T +Y PE +LG E+Y + D+WS G I+ L P F +N LA + Sbjct: 185 ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPC 244 Query: 279 -------IRMGQYEFPNP----------EWSEVSEEVKMLIRNLLKTEPTQRMTITEFMN 321 I++ + P E+S + L+ ++L +P++R T + + Sbjct: 245 PAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQ 304 Query: 322 HPWIMQ 327 ++ Sbjct: 305 SDFLKD 310 >2W96-B nrPDB Length = 306 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 73/301 (24%), Positives = 122/301 (40%), Gaps = 34/301 (11%) Query: 62 DYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR-------REVELHWRA--S 112 Y+ ++ +G+G G V + + + ALK ++ REV L R Sbjct: 5 RYEPVAE-IGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAF 63 Query: 113 QCPHIVRIVDVYENLYAGRK-CLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 + P++VR++DV R+ + +V E +D +L + + ++M+ Sbjct: 64 EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFL 122 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVA 231 + +LH+ I HRD+KPEN+L TS +KL DFG A+ + +L T +Y A Sbjct: 123 RGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALDPVVVTLWYRA 179 Query: 232 PEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMG--------- 282 PEVL Y DMWS+G I + P F N + I + Sbjct: 180 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 239 Query: 283 -------QYEFPNPEWSEVS---EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVP 332 P P S V E L+ +L P +R++ + H ++ + P Sbjct: 240 SLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNP 299 Query: 333 Q 333 + Sbjct: 300 E 300 >5EFQ-A nrPDB Length = 347 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 81/345 (23%), Positives = 143/345 (41%), Gaps = 49/345 (14%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-DCPK------ARREVELHWRAS 112 +D + + ++G G G+V + +K T E ALK ++ D K A RE+++ R Sbjct: 10 VDKFDIIG-IIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKI-LRQL 67 Query: 113 QCPHIVRIVDVYEN------LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 I+ + ++ + + +V E +D +L ++ G F E Sbjct: 68 THQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDH-DLMGLLES-GLVHFNENHIKSF 125 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--LTTPC 224 M+ + E + Y H N HRD+K N+L ++ +KL DFG A+ +S S T Sbjct: 126 MRQLMEGLDYCHKKNFLHRDIKCSNILLNNR---GQIKLADFGLARLYSSEESRPYTNKV 182 Query: 225 YTPYYVAPE-VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTR----- 278 T +Y PE +LG E+Y + D+WS G I+ L P F +N LA + Sbjct: 183 ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPC 242 Query: 279 -------IRMGQYEFPNP----------EWSEVSEEVKMLIRNLLKTEPTQRMTITEFMN 321 I++ + P E+ + L +L +P++R T + + Sbjct: 243 PAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQ 302 Query: 322 HPWIMQS--TKVPQTPLHTSRVLKE--DKERWEDVKEEMTSALAT 362 ++ +K+P L + E K+R + MT ++T Sbjct: 303 CEFLRDVEPSKMPPPDLPLWQDCHELWSKKRRRQKQMGMTDDVST 347 >4AU8-A nrPDB Length = 296 Score = 229 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 81/298 (27%), Positives = 122/298 (40%), Gaps = 44/298 (14%) Query: 62 DYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP-------KARREVELHWRASQC 114 Y+ + +G G G V + N+ T E ALK ++ A RE+ L + + Sbjct: 7 KYEKLEK-IGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICL-LKELKH 64 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 +IVR+ DV + K L +V E D +L D + + + + + Sbjct: 65 KNIVRLHDVLHS----DKKLTLVFEFCDQ-DLKKY-FDSCNGDLDPEIVKSFLFQLLKGL 118 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT-SHNSLTTPCYTPYYVAPE 233 + HS N+ HRD+KP+NLL N LKL DFG A+ + T +Y P+ Sbjct: 119 GFCHSRNVLHRDLKPQNLLIN---RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPD 175 Query: 234 VLGPEK-YDKSCDMWSLGVIMYILL-CGYPPFYSNH------------GLAISPGMKTRI 279 VL K Y S DMWS G I L G P F N G + Sbjct: 176 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 235 Query: 280 RMGQYEFPNPEWSEVSEEV----------KMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 ++ Y+ P P + + V + L++NLLK P QR++ E + HP+ Sbjct: 236 KLPDYK-PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 292 >4BGQ-A nrPDB Length = 304 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 78/301 (25%), Positives = 131/301 (43%), Gaps = 44/301 (14%) Query: 59 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK-------ARREVELHWRA 111 +++ +++ V+G G G VL+ +K T E A+K +D + RE++ R Sbjct: 10 VMNKFEILG-VVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELK-MLRT 67 Query: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 + +IV + + + R L +V E ++ L + + + + + Sbjct: 68 LKQENIVELKEAFR----RRGKLYLVFEYVEKNML--ELLEEMPNGVPPEKVKSYIYQLI 121 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--LTTPCYTPYY 229 +AI + H +I HRD+KPENLL + N +LKL DFGFA+ + N+ T +Y Sbjct: 122 KAIHWCHKNDIVHRDIKPENLLISH---NDVLKLCDFGFARNLSEGNNANYDEEVATRWY 178 Query: 230 VAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL---------------AISPG 274 +PE+L Y KS DMWS+G I+ L G P F + Sbjct: 179 RSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKL 238 Query: 275 MKTRIRMGQYEFP---NPEWSE------VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 + R FP +P+ E ++ + L++NLLK +P R + +NHP Sbjct: 239 FYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF 298 Query: 326 M 326 Sbjct: 299 Q 299 >2XNP-A nrPDB Length = 279 Score = 228 bits (581), Expect = 4e-60, Method: Composition-based stats. Identities = 76/282 (26%), Positives = 125/282 (44%), Gaps = 29/282 (10%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELH------WRASQC 114 +DY+V +G G G+ +I K + K L E ++ R + Sbjct: 6 EDYEVLY-TIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKH 64 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQD--RGDQAFTEREASEIMKSIGE 172 P+IVR D + L IVME +GG+L S I + Q E +M + Sbjct: 65 PNIVRYYDRIID--RTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTL 122 Query: 173 AIQYLHS-----INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL-TTPCYT 226 A++ H + HRD+KP N+ K+ +KL DFG A+ S T T Sbjct: 123 ALKECHRRSDGGHTVLHRDLKPANVFLDGKQN---VKLGDFGLARILNHDTSFAKTFVGT 179 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQY-E 285 PYY++PE + Y++ D+WSLG ++Y L PPF + ++ +IR G++ Sbjct: 180 PYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELA----GKIREGKFRR 235 Query: 286 FPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 P S+E+ +I +L + R ++ E + +P I++ Sbjct: 236 IPY----RYSDELNEIITRMLNLKDYHRPSVEEILENPLILE 273 >5Y86-A nrPDB Length = 588 Score = 227 bits (580), Expect = 5e-60, Method: Composition-based stats. Identities = 67/348 (19%), Positives = 141/348 (40%), Gaps = 69/348 (19%) Query: 50 SGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHW 109 + + + ++ + Y+V +++G G G+V ++++ + ++ ALKM+++ + R+ Sbjct: 196 AYIHVPRDHLAYRYEVL-KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEI 254 Query: 110 RASQCP---------HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTE 160 R + +++ +++ + R + + E L +L+ I+ Q F+ Sbjct: 255 RILEHLKKQDKTGSMNVIHMLESF----TFRNHVCMAFELLS-IDLYELIKKNKFQGFSV 309 Query: 161 REASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL 220 + + +SI +++ LH I H D+KPEN+L ++ K+ DFG + + L Sbjct: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSST-KVIDFGSSCF--EYQKL 366 Query: 221 TTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLA---------- 270 T + +Y APE++ +Y D+WS G I+ LL G P F Sbjct: 367 YTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLG 426 Query: 271 -ISPGMKTRIRMGQYEFPN---PEWSEVSEEV---------------------------- 298 P + + + +Y + P + V+ + Sbjct: 427 MPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTA 486 Query: 299 ---------KMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLH 337 ++ L +P+ R+T + + HPWI +S P T + Sbjct: 487 LKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTID 534 >4C0T-A nrPDB Length = 974 Score = 227 bits (580), Expect = 6e-60, Method: Composition-based stats. Identities = 71/291 (24%), Positives = 126/291 (43%), Gaps = 38/291 (13%) Query: 54 IKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREV 105 I++N D+K + LG G V+ +K T +++A+K+L + E Sbjct: 261 IRRNVT--DFK-FGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEK 317 Query: 106 ELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASE 165 R S ++ + +++ + L V++ GEL + I+ E Sbjct: 318 HALNRLSNRLGVISLYFTFQD----KDSLYFVLDYASNGELLTLIKRYN--TLNEECTRH 371 Query: 166 IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK----------ETT 215 I +AI+Y+H + HRD+KPEN+L K +++TDFG A+ E Sbjct: 372 FGAQILDAIKYMHDNGVIHRDLKPENILLDDK---MRIQITDFGTARLLEKKNDESEEYP 428 Query: 216 SHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGM 275 + T YV+PE+L + K D+W+ G I+Y ++ G PPF + + Sbjct: 429 VDVRAKSFVGTAEYVSPELLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQ-- 486 Query: 276 KTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIM 326 +I Q+ F + ++ LI+ +L +P++R TI E H + Sbjct: 487 --KITKLQFAFS----AGFPTIIRDLIKKILVLQPSRRATIPEIQKHYFFQ 531 >3ALO-A nrPDB Length = 327 Score = 227 bits (579), Expect = 6e-60, Method: Composition-based stats. Identities = 66/302 (21%), Positives = 132/302 (43%), Gaps = 24/302 (7%) Query: 57 NAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWR 110 + +D K + +G G G V ++ +K + + A+K + ++ + ++++ R Sbjct: 18 DFTAEDLKDLGE-IGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMR 76 Query: 111 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLD--GGELFSRIQDRGDQAFTEREASEIMK 168 +S CP+IV+ L+ C I ME + + + + D E +I Sbjct: 77 SSDCPYIVQFYGA---LFREGDC-WICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITL 132 Query: 169 SIGEAIQYL-HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTP 227 + +A+ +L ++ I HRD+KP N+L + +KL DFG + + + T Sbjct: 133 ATVKALNHLKENLKIIHRDIKPSNILLD---RSGNIKLCDFGISGQLVDSIAKTRDAGCR 189 Query: 228 YYVAPEVL----GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQ 283 Y+APE + + YD D+WSLG+ +Y L G P+ + ++ + ++ Sbjct: 190 PYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWN--SVFDQLTQVVKGDP 247 Query: 284 YEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI-MQSTKVPQTPLHTSRVL 342 + N E E S + L + ++R E + HP+I M + + + ++L Sbjct: 248 PQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKIL 307 Query: 343 KE 344 + Sbjct: 308 DQ 309 >5DBX-A nrPDB Length = 328 Score = 227 bits (578), Expect = 9e-60, Method: Composition-based stats. Identities = 69/295 (23%), Positives = 125/295 (42%), Gaps = 42/295 (14%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCP----KARREVELHWRASQC 114 D Y++ +V+G G V K QE+ A+K + + C + +E++ + S Sbjct: 11 DAYEL-QEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCS-H 68 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQ------DRGDQAFTEREASEIMK 168 P++V Y + + L +VM+ L GG + I+ + + E + I+K Sbjct: 69 PNVV----TYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILK 124 Query: 169 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT------T 222 + E + YLH HRD+K N+L + +++ DFG + + +T Sbjct: 125 EVLEGLDYLHRNGQIHRDLKAGNILLGE---DGSVQIADFGVSAFLATGGDVTRNKVRKD 181 Query: 223 PCYTPYYVAPEVLGP-EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRM 281 TP ++APEV+ YD DMWS G+ L G P++ P MK + Sbjct: 182 FVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHK------YPPMKVLMLT 235 Query: 282 GQYEFPNPEW--------SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328 Q + P E + + + L+ L+ +P++R T E + + ++ Sbjct: 236 LQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKA 290 >3DTC-A nrPDB Length = 271 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 72/273 (26%), Positives = 115/273 (42%), Gaps = 34/273 (12%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEKFALK---------MLQDCPKARREVELHWRASQCPH 116 +++G+G GKV + F ++ A+K + Q R+E +L + P+ Sbjct: 11 LEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFA-MLKHPN 67 Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 I+ + V L +VME GG L + + I + Y Sbjct: 68 IIALRGVC----LKEPNLCLVMEFARGGPLNRVL---SGKRIPPDILVNWAVQIARGMNY 120 Query: 177 LHSINI---AHRDVKPENLLYTSKRPNA-----ILKLTDFGFAKETTSHNSLTTPCYTPY 228 LH I HRD+K N+L K N ILK+TDFG A+E ++ Sbjct: 121 LHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMS-AAGAYA 179 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN 288 ++APEV+ + K D+WS GV+++ LL G PF GLA++ G + M + P Sbjct: 180 WMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYG----VAMNKLALPI 235 Query: 289 PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMN 321 P S E L+ + +P R + T ++ Sbjct: 236 P--STCPEPFAKLMEDCWNPDPHSRPSFTNILD 266 >6GQK-A nrPDB Length = 328 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 60/320 (18%), Positives = 119/320 (37%), Gaps = 58/320 (18%) Query: 32 PAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQI-----FNKRT 86 P Q P +FP+ + G + LG G GKV++ Sbjct: 27 PTQLPYDHKWEFPRNRLSFG----------------KTLGAGAFGKVVEATAQGLIKSDA 70 Query: 87 QEKFALKMLQ------DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMEC 140 A+KML+ + E+++ +IV ++ + L++ E Sbjct: 71 AMTVAVKMLKPSAHSTEREALMSELKVLSYLGNHENIVNLLGACTH----GGPTLVITEY 126 Query: 141 LDGGELFSRIQDRGDQA--------------FTEREASEIMKSIGEAIQYLHSINIAHRD 186 G+L + ++ + D+ T + + + +L S N HRD Sbjct: 127 CCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRD 186 Query: 187 VKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTP---YYVAPEVLGPEKYDKS 243 + N+L T I K+ DFG A++ + ++ ++APE + Y Sbjct: 187 LAARNILLTHGN---ITKICDFGLARDIKNDSNYVDKGNARLPVKWMAPESIFNSVYTFE 243 Query: 244 CDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI 302 D+WS G+ ++ L G P+ G+ + I+ G + +PE++ E+ ++ Sbjct: 244 SDVWSYGIFLWELFSLGSSPY---PGMPVDSKFYKMIKEG-FRMSSPEYA--PAEMYDIM 297 Query: 303 RNLLKTEPTQRMTITEFMNH 322 + +P +R T + + Sbjct: 298 KTCWDADPDKRPTFKQIVQD 317 >2OZO-A nrPDB Length = 613 Score = 225 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 75/328 (22%), Positives = 133/328 (40%), Gaps = 44/328 (13%) Query: 4 NSQGQSP-PVPFPAPA-PPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIID 61 NS G +P P +P P P P ++ P P + K + N +I Sbjct: 288 NSDGYTPEPARITSPDKPRPMPMDTSVFESPFSDPE-------ELKDKKLFLKRDNLLIA 340 Query: 62 DYKVTSQVLGLGINGKVLQI--FNKRTQEKFALKMLQ------DCPKARREVELHWRASQ 113 D + LG G G V Q ++ Q A+K+L+ D + RE ++ + Sbjct: 341 DIE-----LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN 395 Query: 114 CPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEA 173 P+IVR++ V + + L++VME GG L + + ++ +E++ + Sbjct: 396 -PYIVRLIGVCQA-----EALMLVMEMAGGGPLHKFLVGKREE-IPVSNVAELLHQVSMG 448 Query: 174 IQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTT----PCYTPYY 229 ++YL N HR++ N+L ++ K++DFG +K + +S T + + Sbjct: 449 MKYLEEKNFVHRNLAARNVLLVNRH---YAKISDFGLSKALGADDSYYTARSAGKWPLKW 505 Query: 230 VAPEVLGPEKYDKSCDMWSLGVIMYI-LLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN 288 APE + K+ D+WS GV M+ L G P+ G + ++ RM Sbjct: 506 YAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM------- 558 Query: 289 PEWSEVSEEVKMLIRNLLKTEPTQRMTI 316 E E+ L+ + + R Sbjct: 559 ECPPECPPELYALMSDCWIYKWEDRPDF 586 >2BRG-A nrPDB Length = 297 Score = 225 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 76/290 (26%), Positives = 127/290 (43%), Gaps = 30/290 (10%) Query: 59 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-----DCPK-ARREVELHWRAS 112 ++D+ + Q LG G G+V N+ T+E A+K++ DCP+ ++E+ ++ + Sbjct: 5 FVEDWDLV-QTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICIN-KML 62 Query: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 ++V+ + +E GGELF RI D E +A + Sbjct: 63 NHENVVKFYG----HRREGNIQYLFLEYCSGGELFDRI--EPDIGMPEPDAQRFFHQLMA 116 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFA---KETTSHNSLTTPCYTPYY 229 + YLH I I HRD+KPENLL + LK++DFG A + L C T Y Sbjct: 117 GVVYLHGIGITHRDIKPENLLLDERDN---LKISDFGLATVFRYNNRERLLNKMCGTLPY 173 Query: 230 VAPEVLGPEKYD-KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN 288 VAPE+L ++ + D+WS G+++ +L G P+ + Y P Sbjct: 174 VAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPW--DQPSDSCQEYSDWKEKKTYLNP- 230 Query: 289 PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPW----IMQSTKVPQT 334 W ++ L+ +L P+ R+TI + W + + K P+ Sbjct: 231 --WKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRV 278 >1V0B-A nrPDB Length = 288 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 71/291 (24%), Positives = 120/291 (41%), Gaps = 41/291 (14%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR-------REVELHWRASQCPHIVRI 120 + +G G G V + N E FALK ++ + RE+ + + + +IV++ Sbjct: 8 EKIGEGTYGVVYKAQNNY-GETFALKKIRLEKEDEGIPSTTIREISI-LKELKHSNIVKL 65 Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 DV +K L++V E LD ++ D + A + + I Y H Sbjct: 66 YDVIHT----KKRLVLVFEHLDQD--LKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDR 119 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT-SHNSLTTPCYTPYYVAPEVLGP-E 238 + HRD+KP+NLL + LK+ DFG A+ T T +Y AP+VL + Sbjct: 120 RVLHRDLKPQNLLINRE---GELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSK 176 Query: 239 KYDKSCDMWSLGVIMYILLCGYPPFYSNH------------GLAISPGMKTRIRMGQYE- 285 KY + D+WS+G I ++ G P F G S + +Y+ Sbjct: 177 KYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDP 236 Query: 286 ----FPNPEW----SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328 + W + E L+ +LK +P QR+T + + H + ++ Sbjct: 237 NFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKEN 287 >4UYA-A nrPDB Length = 340 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 73/332 (21%), Positives = 135/332 (40%), Gaps = 38/332 (11%) Query: 57 NAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK---------ARREVEL 107 + + ++ +++G G G+V + + ++ A+K + P+ RRE L Sbjct: 22 HVAFERLEL-KELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAESVRREARL 78 Query: 108 HWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIM 167 + P+I+ + V + L +V+E GG L + + Sbjct: 79 FA-MLRHPNIIELRGVC----LQQPHLCLVLEFARGGALNRAL---AGRRIPPHVLVNWA 130 Query: 168 KSIGEAIQYLHSIN---IAHRDVKPENLLYTSKRP-----NAILKLTDFGFAKETTSHNS 219 I + YLH I HRD+K N+L K N LK+TDFG A+E Sbjct: 131 VQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTK 190 Query: 220 LTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRI 279 + T ++APEV+ + K D+WS GV+++ LL G P+ GLA++ G+ Sbjct: 191 MAT-AGAYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVN- 248 Query: 280 RMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTS 339 + P P S E L++ + +P R + + ++ + + P + Sbjct: 249 ---KLTLPIP--STCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESF 303 Query: 340 RVLKEDKERWEDVKEEMTSALATMRVDYEQIK 371 +++D W+ ++M L T + + Sbjct: 304 HSMQDD---WKLEIQQMFDELRTKEKELRSRE 332 >3N9X-A nrPDB Length = 432 Score = 225 bits (573), Expect = 4e-59, Method: Composition-based stats. Identities = 89/396 (22%), Positives = 150/396 (37%), Gaps = 99/396 (25%) Query: 51 GLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARR 103 Q KN + D + ++G G G V ++K T++ A+K + DC + R Sbjct: 15 YFQGIKNVHVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILR 74 Query: 104 EVELHWRASQCPHIVRIVD-VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTERE 162 E+ + R + +I+R+ D + + L IV+E D +L + TE Sbjct: 75 EITILNRL-KSDYIIRLYDLIIPDDLLKFDELYIVLEIADS-DLKKL--FKTPIFLTEEH 130 Query: 163 ASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--- 219 I+ ++ ++H I HRD+KP N L + +K+ DFG A+ S Sbjct: 131 IKTILYNLLLGENFIHESGIIHRDLKPANCLLN---QDCSVKVCDFGLARTINSEKDTNI 187 Query: 220 --------------------LTTPCYTPYYVAPE-VLGPEKYDKSCDMWSLGVIMYILL- 257 LT+ T +Y APE +L E Y KS D+WS G I LL Sbjct: 188 VNDLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLN 247 Query: 258 ----------CGYPPFYSNHGLAIS----------------------------------- 272 +P F + +S Sbjct: 248 MLQSHINDPTNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNI 307 Query: 273 --PGMKTRIRMGQYEFP---NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 P + I++ + P ++ +S++ L+ ++LK P +R+TI + ++HP++ Sbjct: 308 NKPEVIKYIKLFPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLKD 367 Query: 328 ---------STKVPQTPLHTSRVLKEDKERWEDVKE 354 STK P VL E + R+ +KE Sbjct: 368 VRKKKLENFSTKKIILPFDDWMVLSETQLRYIFLKE 403 >5O2B-A nrPDB Length = 285 Score = 224 bits (572), Expect = 4e-59, Method: Composition-based stats. Identities = 66/279 (23%), Positives = 124/279 (44%), Gaps = 21/279 (7%) Query: 62 DYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR------REVELHWRASQCP 115 + LG G V + + T + A LQD + +E + Q P Sbjct: 16 RFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHP 75 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 +IVR D +E++ G+KC+++V E + G L + ++ + + + I + +Q Sbjct: 76 NIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKR--FKVMKPKVLRSWCRQILKGLQ 133 Query: 176 YLHSIN--IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPE 233 +LH+ I HRD+K +N+ T P +K+ D G A + + TP ++APE Sbjct: 134 FLHTRTPPIIHRDLKCDNIFIT--GPTGSVKIGDLGLAT-LMRTSFAKSVIGTPEFMAPE 190 Query: 234 VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLA-ISPGMKTRIRMGQYEFPNPEWS 292 + E YD+S D+++ G+ M + P+ A I + + I+ P Sbjct: 191 MY-EEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIK------PASFNK 243 Query: 293 EVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKV 331 EVK +I ++ ++R++I + +NH + + T + Sbjct: 244 VTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGL 282 >6CQF-A nrPDB Length = 297 Score = 224 bits (572), Expect = 5e-59, Method: Composition-based stats. Identities = 74/284 (26%), Positives = 124/284 (43%), Gaps = 25/284 (8%) Query: 54 IKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-----DCPKARREVELH 108 I D Y + + LG G G+V + +K + + ALKM++ D ++E+ + Sbjct: 9 IFNRDPRDHYDLLQR-LGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILI- 66 Query: 109 WRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMK 168 + + +IV Y Y + L I ME G L Q G + +E + S + + Sbjct: 67 LKTCRHANIV----AYHGSYLWLQKLWICMEFCGAGSLQDIYQVTG--SLSELQISYVCR 120 Query: 169 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TPCYTP 227 + + + YLHS HRD+K N+L ++L DFG + + + + TP Sbjct: 121 EVLQGLAYLHSQKKIHRDIKGANILINDA---GEVRLADFGISAQIGATLARRLAFIGTP 177 Query: 228 YYVAPE---VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQY 284 Y++APE V Y++ CD+WSLG+ L PP + H L + M Y Sbjct: 178 YWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMT----KSGY 233 Query: 285 EFPN-PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 + P E + S I+ L P +R + T+ ++H + Q Sbjct: 234 QPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQ 277 >3GC9-A nrPDB Length = 370 Score = 224 bits (572), Expect = 5e-59, Method: Composition-based stats. Identities = 66/332 (19%), Positives = 134/332 (40%), Gaps = 49/332 (14%) Query: 37 PPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ 96 P + Q K+ ++ + + +G G G V ++ R ++K A+K L Sbjct: 9 GPRAGFYRQELNKTVWEVPQRLQ------GLRPVGSGAYGSVCSAYDARLRQKVAVKKLS 62 Query: 97 -------DCPKARREVELHWRASQCPHIVRIVDVYE--NLYAGRKCLLIVMECLDGGELF 147 + RE+ L + + +++ ++DV+ + +V + G +L Sbjct: 63 RPFQSLIHARRTYRELRL-LKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLN 120 Query: 148 SRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTD 207 + ++ QA ++ ++ + ++Y+HS I HRD+KP N+ ++ L++ D Sbjct: 121 NIVKS---QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNE---DSELRILD 174 Query: 208 FGFAKETTSHNSLTTPCYTPYYVAPEV-LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSN 266 FG A++ + +T T +Y APE+ L Y+++ D+WS+G IM LL G F + Sbjct: 175 FGLARQ--ADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGS 232 Query: 267 HGLAISPGMKTRIRMGQYE-------------------FPNPEWSEV----SEEVKMLIR 303 + + + E P + S + + L+ Sbjct: 233 DYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLG 292 Query: 304 NLLKTEPTQRMTITEFMNHPWIMQSTKVPQTP 335 +L + QR++ E + H + Q P Sbjct: 293 RMLVLDSDQRVSAAEALAHAYFSQYHDPEDEP 324 >4E7W-A nrPDB Length = 394 Score = 224 bits (572), Expect = 5e-59, Method: Composition-based stats. Identities = 74/288 (25%), Positives = 126/288 (43%), Gaps = 30/288 (10%) Query: 64 KVTSQVLGLGINGKVLQIFNKRTQEKFALK-MLQDCPKARREVELHWRASQCPHIVRIVD 122 +V+G G G V Q + E A+K +LQD RE+++ R + P++V + Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFKNRELQIM-RIVKHPNVVDLKA 99 Query: 123 VYENLYAGRK--CLLIVMECLDGGELF-SRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 + + + L +V+E + SR + Q M + ++ Y+HS Sbjct: 100 FFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAYIHS 159 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GPE 238 I I HRD+KP+NLL P+ +LKL DFG AK + + + YY APE++ G Sbjct: 160 IGICHRDIKPQNLLLD--PPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPELIFGAT 217 Query: 239 KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLA--------ISPGMKTRIRMGQYEFPNPE 290 Y + D+WS G +M L+ G P F G+ + + +I+ + + Sbjct: 218 NYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNYMEHK 277 Query: 291 WSEV-------------SEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 + ++ + LI LL+ P+ R+T E + HP+ Sbjct: 278 FPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFF 325 >6BXI-A nrPDB Length = 333 Score = 224 bits (571), Expect = 6e-59, Method: Composition-based stats. Identities = 80/313 (25%), Positives = 130/313 (41%), Gaps = 63/313 (20%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQ------ 113 ++D++ +V+G G G+V + K T +A+K+L+ +E H RA + Sbjct: 5 LEDFESL-KVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEA 63 Query: 114 -CPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 +V++ +++ + L ++ME L GG++ + + + TE E + Sbjct: 64 DSLWVVKMFYSFQD----KLNLYLIMEFLPGGDMMTLLMKK--DTLTEEETQFYIAETVL 117 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFA---KETTSHNSLT-------- 221 AI +H + HRD+KP+NLL SK +KL+DFG K+ Sbjct: 118 AIDSIHQLGFIHRDIKPDNLLLDSK---GHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPS 174 Query: 222 -------------------------TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYIL 256 + TP Y+APEV Y+K CD WSLGVIMY + Sbjct: 175 DFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEM 234 Query: 257 LCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI-RNLLKTEPTQRMT 315 L GYPPF S ++ + P +SE+ K LI R + E R+ Sbjct: 235 LIGYPPFCSETP----QETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEH--RIG 288 Query: 316 I---TEFMNHPWI 325 E ++ + Sbjct: 289 APGVEEIKSNSFF 301 >1FVR-A nrPDB Length = 327 Score = 224 bits (570), Expect = 8e-59, Method: Composition-based stats. Identities = 50/278 (17%), Positives = 105/278 (37%), Gaps = 37/278 (13%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEKF--ALKMLQDCPKARR------EVELHWRASQCPHI 117 V+G G G+VL+ K+ + A+K +++ E+E+ + P+I Sbjct: 29 FQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNI 88 Query: 118 VRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRG--------------DQAFTEREA 163 + ++ E+ R L + +E G L ++ + ++ Sbjct: 89 INLLGACEH----RGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQL 144 Query: 164 SEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTP 223 + + YL HRD+ N+L N + K+ DFG ++ + T Sbjct: 145 LHFAADVARGMDYLSQKQFIHRDLAARNILVGE---NYVAKIADFGLSRGQEVYVKKTMG 201 Query: 224 CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMG 282 ++A E L Y + D+WS GV+++ ++ G P+ + + R+ Sbjct: 202 RLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLE 261 Query: 283 QYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM 320 + +EV L+R + +P +R + + + Sbjct: 262 KP-------LNCDDEVYDLMRQCWREKPYERPSFAQIL 292 >5O2C-A nrPDB Length = 380 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 66/279 (23%), Positives = 124/279 (44%), Gaps = 21/279 (7%) Query: 62 DYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR------REVELHWRASQCP 115 + LG G V + + T + A LQD + +E + Q P Sbjct: 25 RFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHP 84 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 +IVR D +E++ G+KC+++V E + G L + ++ + + + I + +Q Sbjct: 85 NIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKR--FKVMKPKVLRSWCRQILKGLQ 142 Query: 176 YLHSIN--IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPE 233 +LH+ I HRD+K +N+ T P +K+ D G A + + TP ++APE Sbjct: 143 FLHTRTPPIIHRDLKCDNIFIT--GPTGSVKIGDLGLAT-LMRTSFAKSVIGTPEFMAPE 199 Query: 234 VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLA-ISPGMKTRIRMGQYEFPNPEWS 292 + E YD+S D+++ G+ M + P+ A I + + I+ P Sbjct: 200 MY-EEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIK------PASFNK 252 Query: 293 EVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKV 331 EVK +I ++ ++R++I + +NH + + T + Sbjct: 253 VTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGL 291 >5UUU-A nrPDB Length = 547 Score = 222 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 66/304 (21%), Positives = 130/304 (42%), Gaps = 32/304 (10%) Query: 39 PPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC 98 +F +F +++ + ++D+ V +++G G G+V T + +A+K L Sbjct: 176 ESDKFTRFCQWKNVELNIHLTMNDFSV-HRIIGRGGFGEVYGCRKADTGKMYAMKCLDKK 234 Query: 99 PKARRE---VELHWRAS-------QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFS 148 ++ + L+ R CP IV + + L +++ ++GG+L Sbjct: 235 RIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHT----PDKLSFILDLMNGGDLHY 290 Query: 149 RIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDF 208 + G F+E + I ++++H+ + +RD+KP N+L + ++++D Sbjct: 291 HLSQHG--VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDE---HGHVRISDL 345 Query: 209 GFAKETTSHNSLTTPCYTPYYVAPEVLGPEK-YDKSCDMWSLGVIMYILLCGYPPFYSNH 267 G A + + + T Y+APEVL YD S D +SLG +++ LL G+ PF H Sbjct: 346 GLACDFSKKKPHAS-VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFR-QH 403 Query: 268 GLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRM-----TITEFMNH 322 + E P+ S E++ L+ LL+ + +R+ E Sbjct: 404 KTKDKHEIDRMTLTMAVELPD----SFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKES 459 Query: 323 PWIM 326 P+ Sbjct: 460 PFFR 463 >3V5Q-A nrPDB Length = 297 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 67/300 (22%), Positives = 118/300 (39%), Gaps = 45/300 (15%) Query: 48 VKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQ--IFN---KRTQEKFALKMLQD----- 97 + SG+ ++ D V + LG G GKV +N + + A+K L+D Sbjct: 3 MHSGIHVQHIKRRD--IVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAA 60 Query: 98 CPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQA 157 +RE EL Q HIV+ V + L++V E + G+L ++ G A Sbjct: 61 RKDFQREAELLTNL-QHEHIVKFYGVCGD----GDPLIMVFEYMKHGDLNKFLRAHGPDA 115 Query: 158 --------------FTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAIL 203 + I I + YL S + HRD+ N L + N ++ Sbjct: 116 MILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGA---NLLV 172 Query: 204 KLTDFGFAKETTSHNSLTTPCYT---PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-G 259 K+ DFG +++ S + +T ++ PE + K+ D+WS GVI++ + G Sbjct: 173 KIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYG 232 Query: 260 YPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEF 319 P++ + + + + +EV ++ + EP QR+ I E Sbjct: 233 KQPWFQLSNTEVIECITQGRVLERPRV-------CPKEVYDVMLGCWQREPQQRLNIKEI 285 >3PVW-A nrPDB Length = 695 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 66/304 (21%), Positives = 130/304 (42%), Gaps = 32/304 (10%) Query: 39 PPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC 98 +F +F +++ + ++D+ V +++G G G+V T + +A+K L Sbjct: 167 ESDKFTRFCQWKNVELNIHLTMNDFSV-HRIIGRGGFGEVYGCRKADTGKMYAMKCLDKK 225 Query: 99 PKARRE---VELHWRAS-------QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFS 148 ++ + L+ R CP IV + + L +++ ++GG+L Sbjct: 226 RIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHT----PDKLSFILDLMNGGDLHY 281 Query: 149 RIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDF 208 + G F+E + I ++++H+ + +RD+KP N+L + ++++D Sbjct: 282 HLSQHG--VFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDE---HGHVRISDL 336 Query: 209 GFAKETTSHNSLTTPCYTPYYVAPEVLGPEK-YDKSCDMWSLGVIMYILLCGYPPFYSNH 267 G A + + + T Y+APEVL YD S D +SLG +++ LL G+ PF H Sbjct: 337 GLACDFSKKKPHAS-VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFR-QH 394 Query: 268 GLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRM-----TITEFMNH 322 + E P+ S E++ L+ LL+ + +R+ E Sbjct: 395 KTKDKHEIDRMTLTMAVELPD----SFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKES 450 Query: 323 PWIM 326 P+ Sbjct: 451 PFFR 454 >4CRS-A nrPDB Length = 341 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 84/335 (25%), Positives = 132/335 (39%), Gaps = 44/335 (13%) Query: 69 VLGLGINGKVLQIFNKRTQEKFALKMLQDCPK-ARREVELHW---------RASQCPHIV 118 VL G GKVL K T E FA+K L+ AR EV+ + + P +V Sbjct: 19 VLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLV 78 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 + ++ ++ + VME GG+L I F+E A + +QYLH Sbjct: 79 NLFACFQT----KEHVCFVMEYAAGGDLMMHIH---TDVFSEPRAVFYAACVVLGLQYLH 131 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TPCYTPYYVAPEVLGP 237 I +R L +K+ DFG KE + T T C TP ++APEVL Sbjct: 132 EHKIVYR---DLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTE 188 Query: 238 EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEE 297 Y ++ D W LGV++Y +L G PF + + I + +P +S E Sbjct: 189 TSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDS----IVNDEVRYPR----FLSTE 240 Query: 298 VKMLIRNLLKTEPTQRMT-----ITEFMNHPWI------MQSTKVPQTPLHTSRVLKEDK 346 ++R LL+ P +R+ + HP+ K + P + +ED Sbjct: 241 AISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDV 300 Query: 347 ERWEDVKEEMTSALATMRV----DYEQIKIKKIED 377 ++D L R E+ ++ + D Sbjct: 301 SNFDDEFTSEAPILTPPREPRILSEEEQEMFRDFD 335 >4OTD-A nrPDB Length = 341 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 76/288 (26%), Positives = 120/288 (41%), Gaps = 35/288 (12%) Query: 55 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK-ARREVELHW---- 109 K ++D+K + VLG G GKVL + + E FA+K L+ AR EVE Sbjct: 6 KSPLTLEDFKFLA-VLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKR 64 Query: 110 -----RASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREAS 164 ++ P +V + ++ + + VME GG+L I F+E A Sbjct: 65 ILAAVTSAGHPFLVNLFGCFQT----PEHVCFVMEYSAGGDLMLHIHS---DVFSEPRAI 117 Query: 165 EIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT-TP 223 + +Q+LH I +R L +K+ DFG KE + T T Sbjct: 118 FYSACVVLGLQFLHEHKIVYR---DLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTF 174 Query: 224 CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQ 283 C TP ++APEVL Y ++ D W LGV++Y +L G PF + + I + Sbjct: 175 CGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDS----IVNDE 230 Query: 284 YEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMT-----ITEFMNHPWIM 326 +P +S E ++R LL+ P +R+ + P+ Sbjct: 231 VRYPR----FLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFR 274 >4PWN-A nrPDB Length = 274 Score = 221 bits (564), Expect = 4e-58, Method: Composition-based stats. Identities = 65/275 (23%), Positives = 119/275 (43%), Gaps = 18/275 (6%) Query: 62 DYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR------REVELHWRASQCP 115 + +G G V + + T + A LQD + +E + Q P Sbjct: 10 RFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHP 69 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 +IVR D +E+ G+KC+++V E + G L + ++ + + + I + +Q Sbjct: 70 NIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKR--FKVMKIKVLRSWCRQILKGLQ 127 Query: 176 YLHSIN--IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPE 233 +LH+ I HRD+K +N+ T P +K+ D G A + + TP ++APE Sbjct: 128 FLHTRTPPIIHRDLKCDNIFIT--GPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPE 185 Query: 234 VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSE 293 + EKYD+S D+++ G+ M + P+ A + R+ G P Sbjct: 186 MY-EEKYDESVDVYAFGMCMLEMATSEYPYSECQNAA---QIYRRVTSG--VKPASFDKV 239 Query: 294 VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328 EVK +I ++ +R +I + +NH + + Sbjct: 240 AIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEE 274 >2VD5-A nrPDB Length = 412 Score = 221 bits (564), Expect = 4e-58, Method: Composition-based stats. Identities = 79/334 (23%), Positives = 134/334 (40%), Gaps = 37/334 (11%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARR-EVELHWRASQCPHIV- 118 DD+++ +V+G G +V + K+T + +A+K++ +R EV +V Sbjct: 61 DDFEIL-KVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDV--LVN 117 Query: 119 ---RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 R + + L +VME GG+L + + G + A + I AI Sbjct: 118 GDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFG-ERIPAEMARFYLAEIVMAID 176 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTT--PCYTPYYVAPE 233 +H + HRD+KP+N+L ++L DFG + + ++ + TP Y++PE Sbjct: 177 SVHRLGYVHRDIKPDNILLD---RCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPE 233 Query: 234 VLG-------PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286 +L Y CD W+LGV Y + G PFY++ +I + Sbjct: 234 ILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAET----YGKIVHYKEHL 289 Query: 287 PNPEWSE-VSEEVKMLIRNLLKTEPTQRM---TITEFMNHPWI-------MQSTKVPQTP 335 P E V EE + I+ LL P R+ +F HP+ ++ + P TP Sbjct: 290 SLPLVDEGVPEEARDFIQRLLCP-PETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTP 348 Query: 336 LHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQ 369 + + ED M S D + Sbjct: 349 DFEGATDTCNFDLVEDGLTAMVSGGGETLSDIRE 382 >4XEY-B nrPDB Length = 408 Score = 221 bits (564), Expect = 4e-58, Method: Composition-based stats. Identities = 60/297 (20%), Positives = 112/297 (37%), Gaps = 28/297 (9%) Query: 29 PHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQE 88 P + P P + ++++ I +K LG G G+V + K+ Sbjct: 100 YPAPKRNKPTVYGVSPNY---DKWEMERTDITMKHK-----LGGGQYGEVYEGVWKKYSL 151 Query: 89 KFALKMLQDCPKARREV---ELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGE 145 A+K L++ E + + P++V+++ V I+ E + G Sbjct: 152 TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVC----TREPPFYIITEFMTYGN 207 Query: 146 LFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKL 205 L +++ Q + I A++YL N HRD+ N L N ++K+ Sbjct: 208 LLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHLVKV 264 Query: 206 TDFGFAKETTSHNS--LTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPP 262 DFG ++ T + + APE L K+ D+W+ GV+++ + G P Sbjct: 265 ADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSP 324 Query: 263 FYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEF 319 + + ++ Y PE E+V L+R + P+ R + E Sbjct: 325 YPGIDLSQVYELLEK-----DYRMERPE--GCPEKVYELMRACWQWNPSDRPSFAEI 374 >3TT0-A nrPDB Length = 382 Score = 220 bits (562), Expect = 6e-58, Method: Composition-based stats. Identities = 60/292 (20%), Positives = 113/292 (38%), Gaps = 45/292 (15%) Query: 62 DYKVTSQVLGLGINGKVLQI------FNKRTQE-KFALKMLQDCPKARR------EVELH 108 D V + LG G G+V+ +K + K A+KML+ + E+E+ Sbjct: 69 DRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMM 128 Query: 109 WRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGD------------- 155 + +I+ ++ L +++E G L +Q R Sbjct: 129 KMIGKHKNIINLLGAC----TQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNP 184 Query: 156 -QAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK-- 212 + + ++ + ++YL S HRD+ N+L T + ++K+ DFG A+ Sbjct: 185 EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI 241 Query: 213 -ETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLA 270 + T ++APE L Y D+WS GV+++ + G P+ Sbjct: 242 HHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEE 301 Query: 271 ISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNH 322 + +K RM + S + E+ M++R+ P+QR T + + Sbjct: 302 LFKLLKEGHRMDKP-------SNCTNELYMMMRDCWHAVPSQRPTFKQLVED 346 >2FO0-A nrPDB Length = 495 Score = 220 bits (561), Expect = 7e-58, Method: Composition-based stats. Identities = 61/328 (18%), Positives = 119/328 (36%), Gaps = 30/328 (9%) Query: 29 PHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQE 88 P + P P + ++++ I +K LG G G+V + K+ Sbjct: 192 YPAPKRNKPTVYGVSPNY---DKWEMERTDITMKHK-----LGGGQYGEVYEGVWKKYSL 243 Query: 89 KFALKMLQDCPKARREV---ELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGE 145 A+K L++ E + + P++V+++ V I+ E + G Sbjct: 244 TVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVC----TREPPFYIITEFMTYGN 299 Query: 146 LFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKL 205 L +++ Q + I A++YL N HR++ N L N ++K+ Sbjct: 300 LLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGE---NHLVKV 356 Query: 206 TDFGFAKETTSHNS--LTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPP 262 DFG ++ T + + APE L K+ D+W+ GV+++ + G P Sbjct: 357 ADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSP 416 Query: 263 FYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNH 322 + + ++ Y PE E+V L+R + P+ R + E H Sbjct: 417 YPGIDLSQVYELLEK-----DYRMERPE--GCPEKVYELMRACWQWNPSDRPSFAEI--H 467 Query: 323 PWIMQSTKVPQTPLHTSRVLKEDKERWE 350 + + L ++ + Sbjct: 468 QAFETMFQESSISDEVEKELGKENLYGQ 495 >4FR4-A nrPDB Length = 384 Score = 220 bits (561), Expect = 7e-58, Method: Composition-based stats. Identities = 71/282 (25%), Positives = 129/282 (45%), Gaps = 26/282 (9%) Query: 55 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARR-EVELHWRASQ 113 ++ D +++ + +G G GKV + T++ +A+K + R EV ++ Q Sbjct: 9 NEDVNFDHFEIL-RAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQ 67 Query: 114 ------CPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIM 167 P +V + +++ + + +V++ L GG+L +Q + F E + Sbjct: 68 IMQGLEHPFLVNLWYSFQD----EEDMFMVVDLLLGGDLRYHLQQ--NVHFKEETVKLFI 121 Query: 168 KSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTP 227 + A+ YL + I HRD+KP+N+L + + +TDF A +TT T Sbjct: 122 CELVMALDYLQNQRIIHRDMKPDNILLDE---HGHVHITDFNIAAMLPRETQITTMAGTK 178 Query: 228 YYVAPEVLGPEK---YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQY 284 Y+APE+ K Y + D WSLGV Y LL G P++ + + T Sbjct: 179 PYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHT-FETTVV 237 Query: 285 EFPNPEWSEVSEEVKMLIRNLLKTEPTQRMT-ITEFMNHPWI 325 +P S S+E+ L++ LL+ P QR + +++ N P++ Sbjct: 238 TYP----SAWSQEMVSLLKKLLEPNPDQRFSQLSDVQNFPYM 275 >1U5R-A nrPDB Length = 348 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 74/317 (23%), Positives = 123/317 (38%), Gaps = 30/317 (9%) Query: 23 PPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIF 82 P T L A P P + ++ + + +G G G V Sbjct: 15 PTTENLYFQGAMDPMPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFAR 74 Query: 83 NKRTQEKFALKML--------QDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCL 134 + R E A+K + + +EV + + P+ ++ Y Y Sbjct: 75 DVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKL-RHPNTIQ----YRGCYLREHTA 129 Query: 135 LIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLY 194 +VME G S + + + E E + + + + YLHS N+ HRDVK N+L Sbjct: 130 WLVMEYCLG--SASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILL 187 Query: 195 TSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG---PEKYDKSCDMWSLGV 251 + ++KL DFG A NS TPY++APEV+ +YD D+WSLG+ Sbjct: 188 SEP---GLVKLGDFGSASIMAPANS---FVGTPYWMAPEVILAMDEGQYDGKVDVWSLGI 241 Query: 252 IMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPT 311 L PP ++ + M + Q E P + SE + + + L+ P Sbjct: 242 TCIELAERKPPLFNMNA------MSALYHIAQNESPALQSGHWSEYFRNFVDSCLQKIPQ 295 Query: 312 QRMTITEFMNHPWIMQS 328 R T + H ++++ Sbjct: 296 DRPTSEVLLKHRFVLRE 312 >6NPU-A nrPDB Length = 298 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 55/260 (21%), Positives = 100/260 (38%), Gaps = 20/260 (7%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREV---ELHWRASQCPHIVRIVD 122 LG G G+V + K+ A+K L++ E + + P++V+++ Sbjct: 30 MKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLG 89 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182 V I+ E + G L +++ Q + I A++YL N Sbjct: 90 VC----TREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNF 145 Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--LTTPCYTPYYVAPEVLGPEKY 240 HRD+ N L N ++K+ DFG ++ T + + APE L K+ Sbjct: 146 IHRDLAARNCLVGE---NHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKF 202 Query: 241 DKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVK 299 D+W+ GV+++ + G P+ + ++ Y PE E+V Sbjct: 203 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEK-----DYRMERPE--GCPEKVY 255 Query: 300 MLIRNLLKTEPTQRMTITEF 319 L+R + P+ R + E Sbjct: 256 ELMRACWQWNPSDRPSFAEI 275 >3E3P-A nrPDB Length = 360 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 83/334 (24%), Positives = 141/334 (42%), Gaps = 40/334 (11%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR-REVELHWRA--SQCPH 116 +D ++V ++ G G G V K T A+K + P+ R RE+++ P+ Sbjct: 22 MDRFQV-ERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRNRELQIMQDLAVLHHPN 80 Query: 117 IVRIVDVYENLYAGRK---CLLIVMECLDGGELFSRIQD--RGDQAFTEREASEIMKSIG 171 IV++ + L + L +VME + L ++ R A + + Sbjct: 81 IVQLQSYFYTLGERDRRDIYLNVVMEYVP-DTLHRCCRNYYRRQVAPPPILIKVFLFQLI 139 Query: 172 EAIQYLH--SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYY 229 +I LH S+N+ HRD+KP N+L + LKL DFG AK+ + + YY Sbjct: 140 RSIGCLHLPSVNVCHRDIKPHNVLVNE--ADGTLKLCDFGSAKKLSPSEPNVAYICSRYY 197 Query: 230 VAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGM--------KTRIR 280 APE++ G + Y + D+WS+G I ++ G P F ++ + + +R Sbjct: 198 RAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSREVLR 257 Query: 281 MGQYEFPNPE--------WSEV--------SEEVKMLIRNLLKTEPTQRMTITEFMNHPW 324 + + WS V ++E L+ LL+ P +RM E + HP+ Sbjct: 258 KLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKPYEALCHPY 317 Query: 325 IMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTS 358 P T L ++ L ED R+ + E+ S Sbjct: 318 F-DELHDPATKLPNNKDLPEDLFRFLPNEIEVMS 350 >5KMM-A nrPDB Length = 329 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 68/326 (20%), Positives = 118/326 (36%), Gaps = 52/326 (15%) Query: 40 PQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNK-----RTQEKFALKM 94 PQ F V IK+ I+ ++ LG G GKV + + A+K Sbjct: 21 PQYFSDACVH---HIKRRDIVLKWE-----LGEGAFGKVFLAECHNLLPEQDKMLVAVKA 72 Query: 95 LQDC-----PKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSR 149 L++ +RE EL Q HIVR V + LL+V E + G+L Sbjct: 73 LKEASESARQDFQREAEL-LTMLQHQHIVRFFGVC----TEGRPLLMVFEYMRHGDLNRF 127 Query: 150 IQDRGDQ-------------AFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTS 196 ++ G + + + + YL ++ HRD+ N L Sbjct: 128 LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVG- 186 Query: 197 KRPNAILKLTDFGFAKETTSHNSLTTPCYT---PYYVAPEVLGPEKYDKSCDMWSLGVIM 253 ++K+ DFG +++ S + T ++ PE + K+ D+WS GV++ Sbjct: 187 --QGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVL 244 Query: 254 YILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQ 312 + + G P+Y + + + EV ++R + EP Q Sbjct: 245 WEIFTYGKQPWYQLSNTEAIDCITQGRELERPR-------ACPPEVYAIMRGCWQREPQQ 297 Query: 313 RMTITEFMNHPWIMQSTKVPQTPLHT 338 R +I + H + + P L Sbjct: 298 RHSIKDV--HARLQALAQAPPVYLDV 321 >4O2Z-A nrPDB Length = 377 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 62/305 (20%), Positives = 120/305 (39%), Gaps = 40/305 (13%) Query: 64 KVTSQVLGLGINGKVLQIFNKRTQEKFALKM-------LQDCPKARREVELHWRASQCPH 116 ++LG+G G + T EK ++K ++D + RE++ R + Sbjct: 47 YTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREID-MMRFFHHEN 105 Query: 117 ---IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEA 173 +V I+ + Y + + +V + ++ + R Q E + I Sbjct: 106 LLNVVNILPPLKREYHSFEDVYVVTPLM---DVDMNVVLRSRQVLEESHMQYFVYQILRG 162 Query: 174 IQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT-SHNSLTTPCYTPYYVAP 232 ++YLHS N+AHRD+KP NL+ + LK+ DFG ++ ++ LT T +Y P Sbjct: 163 LKYLHSANVAHRDLKPANLV---TNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPP 219 Query: 233 EVLGP-EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMG-----QYEF 286 E+L Y + D+WS+G I + P F + + + I ++ Sbjct: 220 ELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEHRE 279 Query: 287 PNPEWSEVSE----------------EVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTK 330 + +E+ + E + + +P++R T + + HP++ Sbjct: 280 ALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAADMLAHPYLAHLHD 339 Query: 331 VPQTP 335 P Sbjct: 340 EEDEP 344 >5H2U-A nrPDB Length = 267 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 58/263 (22%), Positives = 102/263 (38%), Gaps = 23/263 (8%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-----DCPKARREVELHWRASQCPHIVRI 120 + LG G G+V + + + + A+K++ + E++ + + HI+ + Sbjct: 10 LCRKLGSGYFGEVFEGL-WKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKL-RHKHILAL 67 Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 V + + I+ E + G L ++D ++ E +I + E + YL S Sbjct: 68 YAVV----SVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQ 123 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY-YVAPEVLGPEK 239 N HRD+ N+L N + K+ DFG A+ L+ PY + APE L Sbjct: 124 NYIHRDLAARNILVGE---NTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGH 180 Query: 240 YDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEV 298 Y D+WS G++++ + G P+ + Y P P E V Sbjct: 181 YSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAG-----YRMPCP--LECPPSV 233 Query: 299 KMLIRNLLKTEPTQRMTITEFMN 321 L+ +P QR T Sbjct: 234 HKLMLTCWCRDPEQRPTFKALRE 256 >4GS6-A nrPDB Length = 315 Score = 219 bits (557), Expect = 3e-57, Method: Composition-based stats. Identities = 63/274 (22%), Positives = 119/274 (43%), Gaps = 30/274 (10%) Query: 58 AIIDDYKV-TSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRAS---Q 113 +ID ++ +V+G G G V + + + A+K ++ R+ + R Sbjct: 4 HMIDYKEIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQIE-SESERKAFIVELRQLSRVN 60 Query: 114 CPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQ-DRGDQAFTEREASEIMKSIGE 172 P+IV++ N + +VME +GG L++ + +T A + Sbjct: 61 HPNIVKLYGACLN------PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQ 114 Query: 173 AIQYLHSIN---IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYY 229 + YLHS+ + HRD+KP NLL + +LK+ DFG A + +H +T + + Sbjct: 115 GVAYLHSMQPKALIHRDLKPPNLLLVAGG--TVLKICDFGTACDIQTH--MTNNKGSAAW 170 Query: 230 VAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFY--SNHGLAISPGMKTRIRMGQYEFP 287 +APEV Y + CD++S G+I++ ++ PF I + R Sbjct: 171 MAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTR------- 223 Query: 288 NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMN 321 P + + ++ L+ +P+QR ++ E + Sbjct: 224 PPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVK 257 >3NIE-A nrPDB Length = 429 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 87/400 (21%), Positives = 150/400 (37%), Gaps = 103/400 (25%) Query: 51 GLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARR 103 G IK + D+Y++ ++G G G V ++K + A+K + DC + R Sbjct: 18 GAIIKNVKVPDNYEI-KHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILR 76 Query: 104 EVELHWRASQCPHIVRIVD-VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTERE 162 E+ + R + +I+R+ D + L IV+E D +L + TE+ Sbjct: 77 EITILNRL-KSDYIIRLHDLIIPEDLLKFDELYIVLEIADS-DLKKL--FKTPIFLTEQH 132 Query: 163 ASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--- 219 I+ ++ +++H I HRD+KP N L + +K+ DFG A+ S Sbjct: 133 VKTILYNLLLGEKFIHESGIIHRDLKPANCLLN---QDCSVKICDFGLARTINSDKDIHI 189 Query: 220 -----------------------LTTPCYTPYYVAPE-VLGPEKYDKSCDMWSLGVIMYI 255 LT+ T +Y APE +L E Y S D+WS G I Sbjct: 190 VNDLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAE 249 Query: 256 LL-----------CGYPPFYSNHGLAISPGMKTRIRMGQYE------------------- 285 LL +P F + +SP ++ + Sbjct: 250 LLNMMKSHINNPTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDL 309 Query: 286 --------------FPNPE-------WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPW 324 FP + +S +S+E L+ ++L+ +R+TI + ++HP+ Sbjct: 310 KCITKQEVIKYIKLFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPY 369 Query: 325 IMQ---------STKVPQTPLHTSRVLKEDKERWEDVKEE 355 + ST+ P VL E + R+ +KE Sbjct: 370 LKDVRKENLENFSTEKIILPFDDWMVLSETQLRYIFLKEI 409 >3GQL-A nrPDB Length = 326 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 60/292 (20%), Positives = 113/292 (38%), Gaps = 45/292 (15%) Query: 62 DYKVTSQVLGLGINGKVLQI------FNKRTQE-KFALKMLQDCPKARR------EVELH 108 D V + LG G G+V+ +K + K A+KML+ + E+E+ Sbjct: 28 DRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMM 87 Query: 109 WRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGD------------- 155 + +I+ ++ L +++E G L +Q R Sbjct: 88 KMIGKHKNIINLLGAC----TQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNP 143 Query: 156 -QAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK-- 212 + + ++ + ++YL S HRD+ N+L T + ++K+ DFG A+ Sbjct: 144 EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI 200 Query: 213 -ETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLA 270 + T ++APE L Y D+WS GV+++ + G P+ Sbjct: 201 HHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEE 260 Query: 271 ISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNH 322 + +K RM + S + E+ M++R+ P+QR T + + Sbjct: 261 LFKLLKEGHRMDKP-------SNCTNELYMMMRDCWHAVPSQRPTFKQLVED 305 >5X8I-B nrPDB Length = 346 Score = 218 bits (555), Expect = 4e-57, Method: Composition-based stats. Identities = 75/331 (22%), Positives = 139/331 (41%), Gaps = 70/331 (21%) Query: 57 NAIIDDYKVTSQVLGLGINGKVLQIF-NKRTQEKFALKMLQD----CPKARREVELHWRA 111 + + Y++ LG G GKV++ +K A+K++++ C AR E+++ Sbjct: 9 DVLSARYEIV-DTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHL 67 Query: 112 S-QCPH----IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 + P+ V++++ +E+ + IV E L G + I++ G F ++ Sbjct: 68 NTTDPNSTFRCVQMLEWFEH----HGHICIVFELL-GLSTYDFIKENGFLPFRLDHIRKM 122 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKR----------------PNAILKLTDFGF 210 I +++ +LHS + H D+KPEN+L+ N +K+ DFG Sbjct: 123 AYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGS 182 Query: 211 AKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLA 270 A H+S T T +Y APEV+ + + CD+WS+G I+ G+ F ++ Sbjct: 183 ATYDDEHHS--TLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKE 240 Query: 271 -----------ISPGMKTRIRMGQY-EFPNPEWSEVS----------------------- 295 + M + R +Y +W E S Sbjct: 241 HLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVE 300 Query: 296 -EEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 E + LI+ +L+ +P +R+T+ E + HP+ Sbjct: 301 HERLFDLIQKMLEYDPAKRITLREALKHPFF 331 >3CJF-A nrPDB Length = 309 Score = 218 bits (555), Expect = 4e-57, Method: Composition-based stats. Identities = 61/330 (18%), Positives = 124/330 (37%), Gaps = 56/330 (16%) Query: 18 APPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGK 77 P P H P +FP+ + + LG G G+ Sbjct: 2 DPDELPLD---EHCERLPYDASKWEFPRDRLN----------------LGKPLGRGAFGQ 42 Query: 78 VLQI----FNK-RTQEKFALKMLQDCPK------ARREVELHWRASQCPHIVRIVDVYEN 126 V++ +K T A+KML++ E+++ ++V ++ Sbjct: 43 VIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGAC-- 100 Query: 127 LYAGRKCLLIVMECLDGGELFSRIQDRGDQA----------FTEREASEIMKSIGEAIQY 176 L++++E G L + ++ + ++ T + + +++ Sbjct: 101 -TKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEHLICYSFQVAKGMEF 159 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTP---YYVAPE 233 L S HRD+ N+L + K ++K+ DFG A++ ++APE Sbjct: 160 LASRKCIHRDLAARNILLSEKN---VVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPE 216 Query: 234 VLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWS 292 + Y D+WS GV+++ + G P+ G+ I R++ G P+++ Sbjct: 217 TIFDRVYTIQSDVWSFGVLLWEIFSLGASPY---PGVKIDEEFCRRLKEGT-RMRAPDYT 272 Query: 293 EVSEEVKMLIRNLLKTEPTQRMTITEFMNH 322 + E+ + + EP+QR T +E + H Sbjct: 273 --TPEMYQTMLDCWHGEPSQRPTFSELVEH 300 >5O0Y-A nrPDB Length = 579 Score = 217 bits (554), Expect = 5e-57, Method: Composition-based stats. Identities = 76/312 (24%), Positives = 130/312 (41%), Gaps = 34/312 (10%) Query: 41 QQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK 100 ++ + H + Q K + ++D + +LG G +V + F+ Q A+K+ Q Sbjct: 263 RELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKN 322 Query: 101 AR------------REVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFS 148 R RE +H + P IV++ D + V+E +G +L Sbjct: 323 WRDEKKENYHKHACREYRIH-KELDHPRIVKLYDYFS---LDTDSFCTVLEYCEGNDLDF 378 Query: 149 RIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN--IAHRDVKPENLLYTSKRPNAILKLT 206 ++ + +E+EA I+ I A++YL+ I I H D+KP N+L + +K+T Sbjct: 379 YLKQH--KLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKIT 436 Query: 207 DFGFAKETTSHNS--------LTTPCYTPYYVAPEVL----GPEKYDKSCDMWSLGVIMY 254 DFG +K + + T +Y+ PE P K D+WS+GVI Y Sbjct: 437 DFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFY 496 Query: 255 ILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRM 314 L G PF N T ++ + +FP V+ E K IR L R+ Sbjct: 497 QCLYGRKPFGHNQSQQDILQENTILKATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRI 554 Query: 315 TITEFMNHPWIM 326 + + P+++ Sbjct: 555 DVQQLACDPYLL 566 >4OLI-A nrPDB Length = 645 Score = 217 bits (554), Expect = 5e-57, Method: Composition-based stats. Identities = 71/282 (25%), Positives = 116/282 (41%), Gaps = 35/282 (12%) Query: 62 DYKVTSQVLGLGINGKVLQ-IFN---KRTQEKFALKMLQ------DCPKARREVELHWRA 111 Y + LG G GKV ++ T E A+K L+ ++E+++ R Sbjct: 353 RYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDI-LRT 411 Query: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 HI++ E+ G K L +VME + G L + + + I Sbjct: 412 LYHEHIIKYKGCCED--QGEKSLQLVMEYVPLGSLRDYLPRHS---IGLAQLLLFAQQIC 466 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT----TPCYTP 227 E + YLHS + HR++ N+L + R ++K+ DFG AK + Sbjct: 467 EGMAYLHSQHYIHRNLAARNVLLDNDR---LVKIGDFGLAKAVPEGHEYYRVREDGDSPV 523 Query: 228 YYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGY-----PPFYSNHGLAISPGMKTRIRMG 282 ++ APE L K+ + D+WS GV +Y LL PP + I+ G T +R+ Sbjct: 524 FWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLT 583 Query: 283 QY-----EFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEF 319 + P P+ + EV L++N +TE + R T Sbjct: 584 ELLERGERLPRPD--KCPCEVYHLMKNCWETEASFRPTFENL 623 Score = 108 bits (269), Expect = 6e-24, Method: Composition-based stats. Identities = 55/300 (18%), Positives = 99/300 (33%), Gaps = 36/300 (12%) Query: 42 QFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLG--INGK------VLQIFNKRTQEKFALK 93 + Q + + + + Y+ +V G G GK ++ ++ + + LK Sbjct: 41 RVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLK 100 Query: 94 MLQ----DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSR 149 +L D A E H+ + V ++V E ++ G L Sbjct: 101 VLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVC----VRGPENIMVTEYVEHGPLDVW 156 Query: 150 IQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT----SKRPNAILKL 205 ++ + + + A+ YL + N+ H +V N+L ++ + +KL Sbjct: 157 LRRERGH-VPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKL 215 Query: 206 TDFGFAKETTSHNSLTTPCYTPYYVAPEVL--GPEKYDKSCDMWSLGVIMYI-LLCGYPP 262 +D G S ++APE L G + D W G + G P Sbjct: 216 SDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAP 272 Query: 263 FYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNH 322 S P K Q+ P P ++ L L EPTQR + + Sbjct: 273 LQSRS-----PSEKEHFYQRQHRLPEPSC----PQLATLTSQCLTYEPTQRPSFRTILRD 323 >4AT3-A nrPDB Length = 299 Score = 217 bits (554), Expect = 5e-57, Method: Composition-based stats. Identities = 64/274 (23%), Positives = 108/274 (39%), Gaps = 40/274 (14%) Query: 65 VTSQVLGLGINGKVLQ--IFNK---RTQEKFALKMLQDC-----PKARREVELHWRASQC 114 V + LG G GKV +N + + A+K L+D RE EL Q Sbjct: 16 VLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNL-QH 74 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQA-----------FTEREA 163 HIV+ V L++V E + G+L ++ G A T+ + Sbjct: 75 EHIVKFYGVC----VEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQM 130 Query: 164 SEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTP 223 I + I + YL S + HRD+ N L N ++K+ DFG +++ S + Sbjct: 131 LHIAQQIAAGMVYLASQHFVHRDLATRNCLVGE---NLLVKIGDFGMSRDVYSTDYYRVG 187 Query: 224 CYT---PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRI 279 +T ++ PE + K+ D+WSLGV+++ + G P+Y + + Sbjct: 188 GHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGR 247 Query: 280 RMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQR 313 + + +EV L+ + EP R Sbjct: 248 VLQRPR-------TCPQEVYELMLGCWQREPHMR 274 >2XYN-A nrPDB Length = 292 Score = 217 bits (554), Expect = 6e-57, Method: Composition-based stats. Identities = 58/275 (21%), Positives = 104/275 (37%), Gaps = 21/275 (7%) Query: 51 GLQIKKNAIIDDYKVTSQ-VLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREV---E 106 Q ++ +T + LG G G+V K+ A+K L++ E Sbjct: 20 YFQSMDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEA 79 Query: 107 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 + + P++V+++ V IV E + G L +++ + T + Sbjct: 80 AVMKEIKHPNLVQLLGVC----TLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYM 135 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--LTTPC 224 I A++YL N HRD+ N L N ++K+ DFG ++ T Sbjct: 136 ATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHVVKVADFGLSRLMTGDTYTAHAGAK 192 Query: 225 YTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQ 283 + + APE L + D+W+ GV+++ + G P+ + ++ RM Q Sbjct: 193 FPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQ 252 Query: 284 YEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITE 318 E +V L+R K P R + E Sbjct: 253 PE-------GCPPKVYELMRACWKWSPADRPSFAE 280 >4E93-A nrPDB Length = 377 Score = 217 bits (553), Expect = 7e-57, Method: Composition-based stats. Identities = 63/287 (21%), Positives = 116/287 (40%), Gaps = 32/287 (11%) Query: 49 KSGLQIKKNAIIDDYK------VTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD----- 97 KSG+ + + D + V + +G G G+V + A+K ++ Sbjct: 95 KSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPD 154 Query: 98 -CPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQ 156 K +E + + S P+IVR++ V ++ + IVME + GG+ + ++ G Sbjct: 155 LKAKFLQEARILKQYS-HPNIVRLIGVC----TQKQPIYIVMELVQGGDFLTFLRTEG-A 208 Query: 157 AFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS 216 + +++ ++YL S HRD+ N L T K +LK++DFG ++E Sbjct: 209 RLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKN---VLKISDFGMSREEAD 265 Query: 217 HNSLTT---PCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYI-LLCGYPPFYSNHGLAIS 272 + + APE L +Y D+WS G++++ G P+ + Sbjct: 266 GVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTR 325 Query: 273 PGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEF 319 ++ R P PE + V L+ EP QR + + Sbjct: 326 EFVEKGGR-----LPCPEL--CPDAVFRLMEQCWAYEPGQRPSFSTI 365 >5A46-A nrPDB Length = 386 Score = 217 bits (553), Expect = 7e-57, Method: Composition-based stats. Identities = 67/338 (19%), Positives = 124/338 (36%), Gaps = 62/338 (18%) Query: 17 PAPPPQPPTPALPH-PPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGIN 75 P+ TP L + P P + P+ D V + LG G Sbjct: 10 PSRLSSSGTPMLAGVSEYELPEDPRWELPR----------------DRLVLGKPLGEGCF 53 Query: 76 GKVLQI------FNKRTQE-KFALKMLQDCPKARR------EVELHWRASQCPHIVRIVD 122 G+V+ +K + K A+KML+ + E+E+ + +I+ ++ Sbjct: 54 GQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLG 113 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGD--------------QAFTEREASEIMK 168 L +++E G L +Q R + + ++ Sbjct: 114 AC----TQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAY 169 Query: 169 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK---ETTSHNSLTTPCY 225 + ++YL S HRD+ N+L T + ++K+ DFG A+ + T Sbjct: 170 QVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDIHHIDYYKKTTNGRL 226 Query: 226 TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQY 284 ++APE L Y D+WS GV+++ + G P+ + +K RM + Sbjct: 227 PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKP 286 Query: 285 EFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNH 322 S + E+ M++R+ P+QR T + + Sbjct: 287 -------SNCTNELYMMMRDCWHAVPSQRPTFKQLVED 317 >2OGV-A nrPDB Length = 317 Score = 217 bits (553), Expect = 7e-57, Method: Composition-based stats. Identities = 58/315 (18%), Positives = 123/315 (39%), Gaps = 52/315 (16%) Query: 28 LPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQ 87 P Q P +FP+ +++ G + LG G GKV++ Sbjct: 20 TFIDPTQLPYNEKWEFPRNNLQFG----------------KTLGAGAFGKVVEATAFGLG 63 Query: 88 E-----KFALKMLQ------DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLI 136 + K A+KML+ + E+++ Q +IV ++ + +L+ Sbjct: 64 KEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTH----GGPVLV 119 Query: 137 VMECLDGGELFSRIQDRGD--------QAFTEREASEIMKSIGEAIQYLHSINIAHRDVK 188 + E G+L + ++ + + + R+ + + + +L S N HRDV Sbjct: 120 ITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVA 179 Query: 189 PENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTP---YYVAPEVLGPEKYDKSCD 245 N+L T+ + K+ DFG A++ + ++ ++APE + Y D Sbjct: 180 ARNVLLTNGH---VAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSD 236 Query: 246 MWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRN 304 +WS G++++ + G P+ + ++ Y+ P ++ + + +++ Sbjct: 237 VWSYGILLWEIFSLGLNPYPG----ILVNSKFYKLVKDGYQMAQPAFA--PKNIYSIMQA 290 Query: 305 LLKTEPTQRMTITEF 319 EPT R T + Sbjct: 291 CWALEPTHRPTFQQI 305 >2GCD-A nrPDB Length = 309 Score = 217 bits (553), Expect = 7e-57, Method: Composition-based stats. Identities = 68/272 (25%), Positives = 113/272 (41%), Gaps = 30/272 (11%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVELHWRASQCPHIVR 119 + +G G G V + R E A+K + + +EV + + P+ ++ Sbjct: 21 REIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKL-RHPNTIQ 79 Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 Y Y +VME G S + + + E E + + + + YLHS Sbjct: 80 ----YRGCYLREHTAWLVMEYCLG--SASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHS 133 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG--- 236 N+ HRDVK N+L + ++KL DFG A NS TPY++APEV+ Sbjct: 134 HNMIHRDVKAGNILLSEP---GLVKLGDFGSASIMAPANS---FVGTPYWMAPEVILAMD 187 Query: 237 PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSE 296 +YD D+WSLG+ L PP ++ + M + Q E P + SE Sbjct: 188 EGQYDGKVDVWSLGITCIELAERKPPLFNMNA------MSALYHIAQNESPALQSGHWSE 241 Query: 297 EVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328 + + + L+ P R T + H ++++ Sbjct: 242 YFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRE 273 >3RP9-A nrPDB Length = 458 Score = 217 bits (552), Expect = 8e-57, Method: Composition-based stats. Identities = 92/452 (20%), Positives = 157/452 (34%), Gaps = 124/452 (27%) Query: 4 NSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDY 63 ++ G V + + + P P Q P D Y Sbjct: 12 HNSGTQHTVSGSQQEGQQRKQHHSSKPTASMPRPHSDWQIP----------------DRY 55 Query: 64 KVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQCPH 116 ++ ++G G G V + ++K + A+K + DC + RE+ + R H Sbjct: 56 EI-RHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNRL-NHDH 113 Query: 117 IVRIVD-VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 +V+++D V L +V+E D F ++ R TE ++ ++ ++ Sbjct: 114 VVKVLDIVIPKDVEKFDELYVVLEIADSD--FKKLF-RTPVYLTELHIKTLLYNLLVGVK 170 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS------------------- 216 Y+HS I HRD+KP N L + +K+ DFG A+ Sbjct: 171 YVHSAGILHRDLKPANCLVN---QDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNL 227 Query: 217 ---------HNSLTTPCYTPYYVAPE-VLGPEKYDKSCDMWSLGVIMYILLC-------- 258 LT T +Y APE +L E Y ++ D+WS+G I LL Sbjct: 228 VTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAY 287 Query: 259 ---GYPPFYSNHGLAISPGMKT-------------------RIRMGQYE----------- 285 P F + +SP K I E Sbjct: 288 HADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDA 347 Query: 286 ------FPNPEWSEV-------SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ----- 327 FP E +++ S + L++ +L P +R+TI E + HP+ + Sbjct: 348 KRYIRIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFKEVRIAE 407 Query: 328 ----STKVPQTPLHTSRVLKEDKERWEDVKEE 355 +T+ + P + + E + R+ VKE Sbjct: 408 VETNATEKVRLPFNDWMNMDEPQLRYAFVKEI 439 >3EB0-A nrPDB Length = 383 Score = 217 bits (552), Expect = 8e-57, Method: Composition-based stats. Identities = 78/338 (23%), Positives = 138/338 (40%), Gaps = 63/338 (18%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR-REVELHWRASQCPHIVRIVDVY 124 + LG G G V ++F+ + ++FALK + P+ + RE+++ + +I+++VD + Sbjct: 11 LGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKNRELDIM-KVLDHVNIIKLVDYF 69 Query: 125 ENLYAGR----------------------------------KCLLIVMECLDGGELFSRI 150 K L ++ME + L + Sbjct: 70 YTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVP-DTLHKVL 128 Query: 151 QD--RGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDF 208 + R ++ S + + A+ ++HS+ I HRD+KP+NLL SK + LKL DF Sbjct: 129 KSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSK--DNTLKLCDF 186 Query: 209 GFAKETTSHNSLTTPCYTPYYVAPE-VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH 267 G AK+ + +Y APE +LG +Y S D+WS+G + L+ G P F Sbjct: 187 GSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGKPLFSGET 246 Query: 268 GLA---------ISPGMKTRIRMG----QYEFPN---PEWSEVSEE-----VKMLIRNLL 306 + +P + IRM + FP +W ++ E L+ +L Sbjct: 247 SIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKILPEGTPSLAIDLLEQIL 306 Query: 307 KTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKE 344 + EP R+ E M HP+ ++ + + Sbjct: 307 RYEPDLRINPYEAMAHPFFDHLRNSYESEVKNNSNFPH 344 >4XCU-A nrPDB Length = 300 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 58/282 (20%), Positives = 107/282 (37%), Gaps = 36/282 (12%) Query: 62 DYKVTSQVLGLGINGKVLQIF-------NKRTQEKFALKMLQDCPKARR------EVELH 108 D V + LG G G+V++ A+KML+D + E+E+ Sbjct: 17 DRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVM 76 Query: 109 WRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTE-----REA 163 + +I+ ++ V L +++EC G L ++ R +E Sbjct: 77 KLIGRHKNIINLLGVC----TQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVL 132 Query: 164 SEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK---ETTSHNSL 220 + +QYL S HRD+ N+L T + ++K+ DFG A+ + Sbjct: 133 VSCAYQVARGMQYLESRKCIHRDLAARNVLVTE---DNVMKIADFGLARGVHHIDYYKKT 189 Query: 221 TTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRI 279 + ++APE L Y D+WS G++++ + G P+ + ++ Sbjct: 190 SNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGH 249 Query: 280 RMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMN 321 RM + E+ L+R P+QR T + + Sbjct: 250 RMDRP-------PHCPPELYGLMRECWHAAPSQRPTFKQLVE 284 >5G6V-A nrPDB Length = 324 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 69/293 (23%), Positives = 113/293 (38%), Gaps = 40/293 (13%) Query: 64 KVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK------ARREVELHWRASQCPHI 117 + LG G V + +K T ALK ++ + A REV L + + +I Sbjct: 4 YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSL-LKDLKHANI 62 Query: 118 VRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL 177 V + D+ K L +V E LD +L + D G+ + + + Y Sbjct: 63 VTLHDIIHT----EKSLTLVFEYLDK-DLKQYLDDCGN-IINMHNVKLFLFQLLRGLAYC 116 Query: 178 HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK-ETTSHNSLTTPCYTPYYVAPEVLG 236 H + HRD+KP+NLL + LKL DFG A+ ++ + T +Y P++L Sbjct: 117 HRQKVLHRDLKPQNLLINER---GELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILL 173 Query: 237 P-EKYDKSCDMWSLGVIMYILLCGYPPFYSN---------------HGLAISPGMKTRIR 280 Y DMW +G I Y + G P F + PG+ + Sbjct: 174 GSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEE 233 Query: 281 MGQYEFPN-------PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIM 326 Y +P + + L+ LL+ E R++ + M HP+ + Sbjct: 234 FKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFL 286 >2PSQ-A nrPDB Length = 370 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 66/347 (19%), Positives = 127/347 (36%), Gaps = 65/347 (18%) Query: 9 SPPVPFPA--PAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVT 66 +P V + P + + P P +FP+ + Sbjct: 44 TPLVRITTRLSSTADTPMLAGVSE--YELPEDPKWEFPRDKLT----------------L 85 Query: 67 SQVLGLGINGKVLQI----FNKRTQEK---FALKMLQDCPKARR------EVELHWRASQ 113 + LG G G+V+ +K ++ A+KML+D + E+E+ + Sbjct: 86 GKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGK 145 Query: 114 CPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGD--------------QAFT 159 +I+ ++ L +++E G L ++ R + T Sbjct: 146 HKNIINLLGAC----TQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT 201 Query: 160 EREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET---TS 216 ++ + ++YL S HRD+ N+L T N ++K+ DFG A++ Sbjct: 202 FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE---NNVMKIADFGLARDINNIDY 258 Query: 217 HNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGM 275 + T ++APE L Y D+WS GV+M+ + G P+ + + Sbjct: 259 YKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLL 318 Query: 276 KTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNH 322 K RM + + + E+ M++R+ P+QR T + + Sbjct: 319 KEGHRMDKP-------ANCTNELYMMMRDCWHAVPSQRPTFKQLVED 358 >6DBM-A nrPDB Length = 318 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 72/282 (25%), Positives = 116/282 (41%), Gaps = 35/282 (12%) Query: 62 DYKVTSQVLGLGINGKVLQ-IFN---KRTQEKFALKMLQ------DCPKARREVELHWRA 111 Y + LG G GKV ++ T E A+K L+ ++E+++ R Sbjct: 31 RYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQEIDI-LRT 89 Query: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 HI++ E+ AG L +VME + G L + + + I Sbjct: 90 LYHEHIIKYKGCCED--AGAASLQLVMEYVPLGSLRDYLPRHS---IGLAQLLLFAQQIC 144 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT----TPCYTP 227 E + YLHS + HRD+ N+L + R ++K+ DFG AK + Sbjct: 145 EGMAYLHSQHYIHRDLAARNVLLDNDR---LVKIGDFGLAKAVPEGHEYYRVREDGDSPV 201 Query: 228 YYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGY-----PPFYSNHGLAISPGMKTRIRMG 282 ++ APE L K+ + D+WS GV +Y LL PP + I+ G T +R+ Sbjct: 202 FWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLT 261 Query: 283 QY-----EFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEF 319 + P P+ + EV L++N +TE + R T Sbjct: 262 ELLERGERLPRPD--KCPAEVYHLMKNCWETEASFRPTFENL 301 >3MIA-A nrPDB Length = 351 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 66/310 (21%), Positives = 129/310 (41%), Gaps = 48/310 (15%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM--LQDCPK-----ARREVELHWRAS 112 + Y+ ++ +G G G+V + +++T +K ALK +++ + A RE+++ + Sbjct: 16 VSKYEKLAK-IGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKI-LQLL 73 Query: 113 QCPHIVRIVDVYEN----LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMK 168 + ++V ++++ + + +V + + +L + + + FT E +M+ Sbjct: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVK-FTLSEIKRVMQ 131 Query: 169 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET-----TSHNSLTTP 223 + + Y+H I HRD+K N+L T + +LKL DFG A+ + N T Sbjct: 132 MLLNGLYYIHRNKILHRDMKAANVLIT---RDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 Query: 224 CYTPYYVAPEVLGPEK-YDKSCDMWSLGVIMYILLCGYPPFYSNHGL------------- 269 T +Y PE+L E+ Y D+W G IM + P N Sbjct: 189 VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSI 248 Query: 270 --AISPGMKTRIRMGQYEFPNPEWSEVSEEVK---------MLIRNLLKTEPTQRMTITE 318 + P + + E + +V + +K LI LL +P QR+ + Sbjct: 249 TPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDD 308 Query: 319 FMNHPWIMQS 328 +NH + Sbjct: 309 ALNHDFFWSD 318 >3BEA-A nrPDB Length = 333 Score = 215 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 58/335 (17%), Positives = 129/335 (38%), Gaps = 58/335 (17%) Query: 28 LPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQ 87 P Q P +FP+ +++ G + LG G GKV++ Sbjct: 28 TFIDPTQLPYNEKWEFPRNNLQFG----------------KTLGAGAFGKVVEATAFGLG 71 Query: 88 E-----KFALKMLQ------DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLI 136 + K A+KML+ + E+++ Q +IV ++ + +L+ Sbjct: 72 KEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTH----GGPVLV 127 Query: 137 VMECLDGGELFSRIQDRG------------DQAFTEREASEIMKSIGEAIQYLHSINIAH 184 + E G+L + ++ + + + R+ + + + +L S N H Sbjct: 128 ITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLLHFSSQVAQGMAFLASKNCIH 187 Query: 185 RDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTP---YYVAPEVLGPEKYD 241 RDV N+L T+ + K+ DFG A++ + ++ ++APE + Y Sbjct: 188 RDVAARNVLLTNGH---VAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYT 244 Query: 242 KSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 300 D+WS G++++ + G P+ + ++ Y+ P ++ + + Sbjct: 245 VQSDVWSYGILLWEIFSLGLNPYPG----ILVNSKFYKLVKDGYQMAQPAFA--PKNIYS 298 Query: 301 LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTP 335 +++ EPT R T + + ++ + + + Sbjct: 299 IMQACWALEPTHRPTFQQICS--FLQEQAQEDRRE 331 >2H8H-A nrPDB Length = 535 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 53/275 (19%), Positives = 107/275 (38%), Gaps = 30/275 (10%) Query: 56 KNAIIDDYKVTSQ------VLGLGINGKVLQIFNKRTQEKFALKMLQDCPKA----RREV 105 + D +++ + LG G G+V T + A+K L+ + +E Sbjct: 255 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFLQEA 313 Query: 106 ELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASE 165 ++ + + +V++ V + + IV E + G L ++ + + + Sbjct: 314 QVMKKL-RHEKLVQLYAVV-----SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD 367 Query: 166 IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLTTP 223 + I + Y+ +N HRD++ N+L N + K+ DFG A+ E + + Sbjct: 368 MAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLIEDNEYTARQGA 424 Query: 224 CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMG 282 + + APE ++ D+WS G+++ L G P+ + ++ Sbjct: 425 KFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---- 480 Query: 283 QYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTIT 317 Y P P E E + L+ + EP +R T Sbjct: 481 -YRMPCP--PECPESLHDLMCQCWRKEPEERPTFE 512 >3KRL-A nrPDB Length = 335 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 58/337 (17%), Positives = 129/337 (38%), Gaps = 60/337 (17%) Query: 28 LPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQ 87 P Q P +FP+ +++ G + LG G GKV++ Sbjct: 28 TFIDPTQLPYNEKWEFPRNNLQFG----------------KTLGAGAFGKVVEATAFGLG 71 Query: 88 E-----KFALKMLQ------DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLI 136 + K A+KML+ + E+++ Q +IV ++ + +L+ Sbjct: 72 KEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTH----GGPVLV 127 Query: 137 VMECLDGGELFSRIQDRGD--------------QAFTEREASEIMKSIGEAIQYLHSINI 182 + E G+L + ++ + + + R+ + + + +L S N Sbjct: 128 ITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNC 187 Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTP---YYVAPEVLGPEK 239 HRDV N+L T+ + K+ DFG A++ + ++ ++APE + Sbjct: 188 IHRDVAARNVLLTNGH---VAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCV 244 Query: 240 YDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEV 298 Y D+WS G++++ + G P+ + ++ Y+ P ++ + + Sbjct: 245 YTVQSDVWSYGILLWEIFSLGLNPYPG----ILVNSKFYKLVKDGYQMAQPAFA--PKNI 298 Query: 299 KMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTP 335 +++ EPT R T + + ++ + + + Sbjct: 299 YSIMQACWALEPTHRPTFQQICS--FLQEQAQEDRRE 333 >1UA2-A nrPDB Length = 346 Score = 214 bits (546), Expect = 5e-56, Method: Composition-based stats. Identities = 78/337 (23%), Positives = 129/337 (38%), Gaps = 50/337 (14%) Query: 62 DYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK----------ARREVELHWRA 111 Y+ LG G V + +K T + A+K ++ + A RE++L Sbjct: 11 RYEKL-DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Query: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 S P+I+ ++D + + + + +V + ++ I T M Sbjct: 70 S-HPNIIGLLDAFGH----KSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTL 122 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT-SHNSLTTPCYTPYYV 230 + ++YLH I HRD+KP NLL N +LKL DFG AK + + T T +Y Sbjct: 123 QGLEYLHQHWILHRDLKPNNLLLDE---NGVLKLADFGLAKSFGSPNRAYTHQVVTRWYR 179 Query: 231 APEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE---- 285 APE+L G Y DMW++G I+ LL P + L + + E Sbjct: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 Query: 286 ------------FPNPEWSEVS----EEVKMLIRNLLKTEPTQRMTITEFMNHPWI---- 325 FP + +++ LI+ L P R+T T+ + + Sbjct: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRP 299 Query: 326 --MQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL 360 ++P+ LKE +K + T AL Sbjct: 300 GPTPGCQLPRPNCPV-ETLKEQSNPALAIKRKRTEAL 335 >3G0E-A nrPDB Length = 336 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 62/321 (19%), Positives = 119/321 (37%), Gaps = 60/321 (18%) Query: 32 PAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQI-----FNKRT 86 P Q P +FP+ + G + LG G GKV++ Sbjct: 32 PTQLPYDHKWEFPRNRLSFG----------------KTLGAGAFGKVVEATAYGLIKSDA 75 Query: 87 QEKFALKMLQ------DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMEC 140 A+KML+ + E+++ +IV ++ L++ E Sbjct: 76 AMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC----TIGGPTLVITEY 131 Query: 141 LDGGELFSRIQDRGDQAFTEREASEIM----------------KSIGEAIQYLHSINIAH 184 G+L + ++ + D + + IM + + + +L S N H Sbjct: 132 CCYGDLLNFLRRKRDSFICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIH 191 Query: 185 RDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTP---YYVAPEVLGPEKYD 241 RD+ N+L T R I K+ DFG A++ + ++ ++APE + Y Sbjct: 192 RDLAARNILLTHGR---ITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYT 248 Query: 242 KSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 300 D+WS G+ ++ L G P+ G+ + I+ G + +PE E+ Sbjct: 249 FESDVWSYGIFLWELFSLGSSPY---PGMPVDSKFYKMIKEG-FRMLSPE--HAPAEMYD 302 Query: 301 LIRNLLKTEPTQRMTITEFMN 321 +++ +P +R T + + Sbjct: 303 IMKTCWDADPLKRPTFKQIVQ 323 >3GC0-A nrPDB Length = 329 Score = 214 bits (545), Expect = 6e-56, Method: Composition-based stats. Identities = 64/306 (20%), Positives = 121/306 (39%), Gaps = 42/306 (13%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK-------ARREVELHWRAS 112 ID Y+ ++ LG G G+V + + T E A+K ++ + A REV L + Sbjct: 33 IDRYRRITK-LGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSL-LKEL 90 Query: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 Q +I+ + V + + L ++ E + +L + D + R + + Sbjct: 91 QHRNIIELKSVIHHNHR----LHLIFEYAEN-DLKKYMDKNPD--VSMRVIKSFLYQLIN 143 Query: 173 AIQYLHSINIAHRDVKPENLLY--TSKRPNAILKLTDFGFAKETT-SHNSLTTPCYTPYY 229 + + HS HRD+KP+NLL + +LK+ DFG A+ T T +Y Sbjct: 144 GVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWY 203 Query: 230 VAPEVLGP-EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE--- 285 PE+L Y S D+WS+ I +L P F + + + + + Sbjct: 204 RPPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWP 263 Query: 286 --FPNPEWSEVSEEVK-MLIRN----------------LLKTEPTQRMTITEFMNHPWIM 326 P+W + + + ++ +L+ +P +R++ + HP+ Sbjct: 264 GVTALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYFS 323 Query: 327 QSTKVP 332 + P Sbjct: 324 HNDFDP 329 >6F3F-A nrPDB Length = 455 Score = 214 bits (545), Expect = 6e-56, Method: Composition-based stats. Identities = 53/275 (19%), Positives = 108/275 (39%), Gaps = 30/275 (10%) Query: 56 KNAIIDDYKVTSQ------VLGLGINGKVLQIFNKRTQEKFALKMLQDCPKA----RREV 105 + D +++ + LG G G+V T + A+K L+ + +E Sbjct: 175 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFLQEA 233 Query: 106 ELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASE 165 ++ + + +V++ V + + IV E ++ G L ++ + + + Sbjct: 234 QVMKKL-RHEKLVQLYAVV-----SEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVD 287 Query: 166 IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLTTP 223 + I + Y+ +N HRD++ N+L N + K+ DFG A+ E + + Sbjct: 288 MSAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLIEDNEYTARQGA 344 Query: 224 CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMG 282 + + APE ++ D+WS G+++ L G P+ + ++ Sbjct: 345 KFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---- 400 Query: 283 QYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTIT 317 Y P P E E + L+ + EP +R T Sbjct: 401 -YRMPCP--PECPESLHDLMCQCWRKEPEERPTFE 432 >3VN9-A nrPDB Length = 340 Score = 214 bits (545), Expect = 6e-56, Method: Composition-based stats. Identities = 71/311 (22%), Positives = 117/311 (37%), Gaps = 28/311 (9%) Query: 29 PHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQE 88 P PP + + G Q DD + + LG G G V ++ + + + Sbjct: 20 FEQPQTSSTPPRDLDSKACISIGNQ-NFEVKADDLEPIME-LGRGAYGVVEKMRHVPSGQ 77 Query: 89 KFALKML------QDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLD 142 A+K + Q+ + ++++ R CP V + I ME +D Sbjct: 78 IMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALF----REGDVWICMELMD 133 Query: 143 GGELFSRIQD--RGDQAFTEREASEIMKSIGEAIQYLHSI-NIAHRDVKPENLLYTSKRP 199 L + Q E +I SI +A+++LHS ++ HRDVKP N+L + Sbjct: 134 T-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINAL-- 190 Query: 200 NAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG----PEKYDKSCDMWSLGVIMYI 255 +K+ DFG + + T Y+APE + + Y D+WSLG+ M Sbjct: 191 -GQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIE 249 Query: 256 LLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMT 315 L P+ + +K + + P + S E LK +R T Sbjct: 250 LAILRFPY--DSWGTPFQQLKQVVEEPSPQLPA---DKFSAEFVDFTSQCLKKNSKERPT 304 Query: 316 ITEFMNHPWIM 326 E M HP+ Sbjct: 305 YPELMQHPFFT 315 >2WTK-C nrPDB Length = 305 Score = 214 bits (545), Expect = 6e-56, Method: Composition-based stats. Identities = 70/300 (23%), Positives = 131/300 (43%), Gaps = 30/300 (10%) Query: 64 KVTSQVLGLGINGKVLQIFNKRTQEKFALKML---------QDCPKARREVELHWRASQC 114 + +LG G GKV ++ + T + A+K+L ++E++L R + Sbjct: 7 YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL-RH 65 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 +++++VDV N ++ + +VME G + + ++ F +A + + + Sbjct: 66 KNVIQLVDVLYN--EEKQKMYMVMEYCVCG-MQEMLDSVPEKRFPVCQAHGYFCQLIDGL 122 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS---HNSLTTPCYTPYYVA 231 +YLHS I H+D+KP NLL T+ LK++ G A+ ++ T +P + Sbjct: 123 EYLHSQGIVHKDIKPGNLLLTT---GGTLKISALGVAEALHPFAADDTCRTSQGSPAFQP 179 Query: 232 PEVLGPEKY--DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNP 289 PE+ D+WS GV +Y + G PF ++ + I G Y P Sbjct: 180 PEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYK----LFENIGKGSYAIPGD 235 Query: 290 EWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERW 349 +S L++ +L+ EP +R +I + H W + + P+ + K+RW Sbjct: 236 CGPPLS----DLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPS-PDTKDRW 290 >2I6L-A nrPDB Length = 320 Score = 214 bits (544), Expect = 8e-56, Method: Composition-based stats. Identities = 71/311 (22%), Positives = 124/311 (39%), Gaps = 49/311 (15%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKML-----QDCPKARREVELHWRASQCPHIVRIVD 122 + LG G NG V + ++ A+K + Q A RE+++ R +IV++ + Sbjct: 17 KPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRL-DHDNIVKVFE 75 Query: 123 VYE----------NLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 + + IV E ++ +L + ++ E A M + Sbjct: 76 ILGPSGSQLTDDVGSLTELNSVYIVQEYMET-DLANVLEQ---GPLLEEHARLFMYQLLR 131 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS----LTTPCYTPY 228 ++Y+HS N+ HRD+KP NL ++ + +LK+ DFG A+ H S L+ T + Sbjct: 132 GLKYIHSANVLHRDLKPANLFINTE--DLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKW 189 Query: 229 YVAPE-VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRI-------- 279 Y +P +L P Y K+ DMW+ G I +L G F H L + I Sbjct: 190 YRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDR 249 Query: 280 --------RMGQYEFPNPEW------SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 + + P +S E + +L P R+T E ++HP++ Sbjct: 250 QELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALSHPYM 309 Query: 326 MQSTKVPQTPL 336 + P+ Sbjct: 310 SIYSFPMDEPI 320 >5X5O-A nrPDB Length = 310 Score = 214 bits (544), Expect = 9e-56, Method: Composition-based stats. Identities = 59/308 (19%), Positives = 118/308 (38%), Gaps = 26/308 (8%) Query: 71 GLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAG 130 G G G V + ++ A+K L K E E+ S +I++ V Sbjct: 24 GGGSFGSVYRAKWISQDKEVAVKKLLKIEK---EAEILSVLS-HRNIIQFYGVI----LE 75 Query: 131 RKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI---NIAHRDV 187 IV E G L+ I + + + + YLH + HRD+ Sbjct: 76 PPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDL 135 Query: 188 KPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMW 247 K N++ + + +LK+ DFG ++ +H + + T ++APEV+ ++CD + Sbjct: 136 KSRNVVIAA---DGVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTY 191 Query: 248 SLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLK 307 S GV+++ +L PF GL ++ + + + P S L+ + Sbjct: 192 SYGVVLWEMLTREVPFKGLEGLQVAWLVVE--KNERLTIP----SSCPRSFAELLHQCWE 245 Query: 308 TEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALA--TMRV 365 + +R + + ++ I++S + +K W E L + Sbjct: 246 ADAKKRPSFKQIIS---ILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDL 302 Query: 366 DYEQIKIK 373 +++ ++K Sbjct: 303 SFKEQELK 310 >4EBW-A nrPDB Length = 304 Score = 213 bits (543), Expect = 9e-56, Method: Composition-based stats. Identities = 66/277 (23%), Positives = 106/277 (38%), Gaps = 35/277 (12%) Query: 62 DYKV------TSQVLGLGINGKVLQIFNKRTQEK---FALKMLQDC------PKARREVE 106 DY++ + +G G G V Q + A+K ++C K +E Sbjct: 32 DYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQE-A 90 Query: 107 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 L R PHIV+++ V + I+ME GEL S +Q R + Sbjct: 91 LTMRQFDHPHIVKLIGVI-----TENPVWIIMELCTLGELRSFLQVRK-YSLDLASLILY 144 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY- 225 + A+ YL S HRD+ N+L +S N +KL DFG ++ Sbjct: 145 AYQLSTALAYLESKRFVHRDIAARNVLVSS---NDCVKLGDFGLSRYMEDSTYYKASKGK 201 Query: 226 -TPYYVAPEVLGPEKYDKSCDMWSLGVIMYI-LLCGYPPFYSNHGLAISPGMKTRIRMGQ 283 ++APE + ++ + D+W GV M+ L+ G PF + RI G+ Sbjct: 202 LPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVI----GRIENGE 257 Query: 284 YEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM 320 P P + L+ +P++R TE Sbjct: 258 -RLPMP--PNCPPTLYSLMTKCWAYDPSRRPRFTELK 291 >6FYV-A nrPDB Length = 337 Score = 213 bits (543), Expect = 1e-55, Method: Composition-based stats. Identities = 73/328 (22%), Positives = 131/328 (39%), Gaps = 64/328 (19%) Query: 57 NAIIDDYKVTSQVLGLGINGKVLQIFNKR-TQEKFALKMLQDCPKARREVELHWRASQCP 115 + + Y++ LG G GKV++ + A+K++++ + R + + Sbjct: 10 DVLRARYEIV-DTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHL 68 Query: 116 H------IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 169 + + R V + E + + IV E L G + I++ F ++ Sbjct: 69 NSTDPNSVFRCVQMLEW-FDHHGHVCIVFELL-GLSTYDFIKENSFLPFQIDHIRQMAYQ 126 Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKR----------------PNAILKLTDFGFAKE 213 I ++I +LH + H D+KPEN+L+ N +K+ DFG A Sbjct: 127 ICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATY 186 Query: 214 TTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLA--- 270 H+S T T +Y APEV+ + + CD+WS+G I+ G+ F ++ Sbjct: 187 DDEHHS--TLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLA 244 Query: 271 --------ISPGMKTRIRMGQY-EFPNPEWSEVS------------------------EE 297 I M + R +Y +W E S E+ Sbjct: 245 MMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEK 304 Query: 298 VKMLIRNLLKTEPTQRMTITEFMNHPWI 325 + L+R +L+ +PTQR+T+ E + HP+ Sbjct: 305 LFDLVRRMLEYDPTQRITLDEALQHPFF 332 >3PPZ-A nrPDB Length = 309 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 68/280 (24%), Positives = 121/280 (43%), Gaps = 29/280 (10%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQCPHIV 118 + +G G G V + A+K+L + + REV + R + P+IV Sbjct: 41 IKEKIGAGSFGTVHRAEWH--GSDVAVKILMEQDFHAERVNEFLREVAIMKRL-RHPNIV 97 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRG-DQAFTEREASEIMKSIGEAIQYL 177 ++ L IV E L G L+ + G + ER + + + + YL Sbjct: 98 ----LFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYL 153 Query: 178 HSIN--IAHRDVKPENLLYTSKRPNAILKLTDFGFAK-ETTSHNSLTTPCYTPYYVAPEV 234 H+ N I HRD+K NLL K +K+ DFG ++ + ++ S + TP ++APEV Sbjct: 154 HNRNPPIVHRDLKSPNLLVDKKY---TVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEV 210 Query: 235 LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 294 L E ++ D++S GVI++ L P+ + + + + + + + E P + Sbjct: 211 LRDEPSNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCK--RLEIPR----NL 264 Query: 295 SEEVKMLIRNLLKTEPTQRMTITEFMN--HPWIMQSTKVP 332 + +V +I EP +R + M+ P I + P Sbjct: 265 NPQVAAIIEGCWTNEPWKRPSFATIMDLLRPLIKSAVPPP 304 >5GRN-A nrPDB Length = 356 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 63/327 (19%), Positives = 121/327 (37%), Gaps = 68/327 (20%) Query: 32 PAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQ--IFNKRTQE- 88 P Q P +FP+ D V +VLG G GKV++ + + Sbjct: 32 PMQLPYDSRWEFPR----------------DGLVLGRVLGSGAFGKVVEGTAYGLSRSQP 75 Query: 89 --KFALKMLQ------DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMEC 140 K A+KML+ + E+++ +IV ++ + I+ E Sbjct: 76 VMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGAC----TKSGPIYIITEY 131 Query: 141 LDGGELFSRIQDRGD------------------------QAFTEREASEIMKSIGEAIQY 176 G+L + + D + T + + +++ Sbjct: 132 CFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEF 191 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT---PYYVAPE 233 L S N HRD+ N+L + I+K+ DFG A++ ++ + T ++APE Sbjct: 192 LASKNCVHRDLAARNVLLAQGK---IVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPE 248 Query: 234 VLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWS 292 + Y D+WS G++++ + G P+ G+ + +I+ G Y P+ Sbjct: 249 SIFDNLYTTLSDVWSYGILLWEIFSLGGTPY---PGMMVDSTFYNKIKSG-YRMAKPD-- 302 Query: 293 EVSEEVKMLIRNLLKTEPTQRMTITEF 319 + EV ++ +EP +R + Sbjct: 303 HATSEVYEIMVKCWNSEPEKRPSFYHL 329 >5EG3-A nrPDB Length = 334 Score = 212 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 63/331 (19%), Positives = 123/331 (37%), Gaps = 63/331 (19%) Query: 23 PPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQI- 81 P + + P P +FP+ + + LG G G+V+ Sbjct: 14 PMLAGVSE--FELPEDPKWEFPRDKLT----------------LGKPLGEGAFGQVVMAE 55 Query: 82 ---FNKRTQEK---FALKMLQDCPKARR------EVELHWRASQCPHIVRIVDVYENLYA 129 +K ++ A+KML+D + E+E+ + +I+ ++ Sbjct: 56 AVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGAC----T 111 Query: 130 GRKCLLIVMECLDGGELFSRIQDRGD--------------QAFTEREASEIMKSIGEAIQ 175 L +++ G L ++ R + T ++ + ++ Sbjct: 112 QDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQMTFKDLVSCTYQLARGME 171 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL---TTPCYTPYYVAP 232 YL S HRD+ N+L T N ++K+ DFG A++ + + T ++AP Sbjct: 172 YLASQKCIHRDLAARNVLVTE---NNVMKIADFGLARDINNIDFFKETTNGRLPVKWMAP 228 Query: 233 EVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW 291 E L Y D+WS GV+M+ + G P+ + +K RM + Sbjct: 229 EALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKP------- 281 Query: 292 SEVSEEVKMLIRNLLKTEPTQRMTITEFMNH 322 + + E+ M++R+ P+QR T + + Sbjct: 282 ANCTNELYMMMRDCWHAVPSQRPTFKQLVED 312 >4R7H-A nrPDB Length = 343 Score = 212 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 58/328 (17%), Positives = 123/328 (37%), Gaps = 65/328 (19%) Query: 28 LPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQ 87 P Q P +FP+ +++ G + LG G GKV++ Sbjct: 32 TFIDPTQLPYNEKWEFPRNNLQFG----------------KTLGAGAFGKVVEATAFGLG 75 Query: 88 E-----KFALKMLQ------DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLI 136 + K A+KML+ + E+++ Q +IV ++ + +L+ Sbjct: 76 KEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTH----GGPVLV 131 Query: 137 VMECLDGGELFSRIQDRGD---------------------QAFTEREASEIMKSIGEAIQ 175 + E G+L + ++ + + + R+ + + + Sbjct: 132 ITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMA 191 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTP---YYVAP 232 +L S N HRDV N+L T+ + K+ DFG A++ + ++ ++AP Sbjct: 192 FLASKNCIHRDVAARNVLLTNGH---VAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAP 248 Query: 233 EVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW 291 E + Y D+WS G++++ + G P+ + ++ Y+ P + Sbjct: 249 ESIFDSVYTVQSDVWSYGILLWEIFSLGLNPYPG----ILVNSKFYKLVKDGYQMAQPAF 304 Query: 292 SEVSEEVKMLIRNLLKTEPTQRMTITEF 319 + + + +++ EPT R T + Sbjct: 305 A--PKNIYSIMQACWALEPTHRPTFQQI 330 >4P5Q-A nrPDB Length = 361 Score = 212 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 59/269 (21%), Positives = 115/269 (42%), Gaps = 30/269 (11%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEK---FALKMLQ--DCPKARR----EVELHWRASQCPH 116 +V+G G G+V K +K A+K L+ K RR E + + P+ Sbjct: 37 IDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQ-FDHPN 95 Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 I+R+ E + K ++IV E ++ G L S ++ D FT + +++ I ++Y Sbjct: 96 IIRL----EGVVTKSKPVMIVTEYMENGSLDSFLRKH-DAQFTVIQLVGMLRGIASGMKY 150 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCY--TPYYVAP 232 L + HRD+ N+L S N + K++DFG ++ E + TT + +P Sbjct: 151 LSDMGYVHRDLAARNILINS---NLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSP 207 Query: 233 EVLGPEKYDKSCDMWSLGVIMYI-LLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW 291 E + K+ + D+WS G++++ + G P++ + + Y P P Sbjct: 208 EAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEG-----YRLPPP-- 260 Query: 292 SEVSEEVKMLIRNLLKTEPTQRMTITEFM 320 + + L+ + + + R + + Sbjct: 261 MDCPAALYQLMLDCWQKDRNNRPKFEQIV 289 >6HV0-A nrPDB Length = 416 Score = 212 bits (540), Expect = 3e-55, Method: Composition-based stats. Identities = 70/316 (22%), Positives = 133/316 (42%), Gaps = 26/316 (8%) Query: 67 SQVLGLGINGK-VLQIFNKRTQEKFALK-MLQDCPK-ARREVELHWRASQCPHIVRIVDV 123 VLG G G V + A+K +L +C A REV+L + + P+++R Sbjct: 13 KDVLGHGAEGTIVYRGM--FDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIR---- 66 Query: 124 YENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIA 183 Y R+ I +E L ++ + +++ + +LHS+NI Sbjct: 67 YFCTEKDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPI-TLLQQTTSGLAHLHSLNIV 124 Query: 184 HRDVKPENLLYTSKRPNAILK--LTDFGFAKET----TSHNSLTTPCYTPYYVAPEVLG- 236 HRD+KP N+L + + +K ++DFG K+ S + + T ++APE+L Sbjct: 125 HRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSE 184 Query: 237 --PEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSE 293 E + D++S G + Y ++ G PF G ++ + + +PE E Sbjct: 185 DCKENPTYTVDIFSAGCVFYYVISEGSHPF----GKSLQRQANILLGACSLDCLHPEKHE 240 Query: 294 VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVK 353 + LI ++ +P +R + + HP+ K Q S ++++ VK Sbjct: 241 -DVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVK 299 Query: 354 EEMTSALATMRVDYEQ 369 + A +++D+ + Sbjct: 300 QLERGGRAVVKMDWRE 315 >5SYS-A nrPDB Length = 286 Score = 212 bits (539), Expect = 3e-55, Method: Composition-based stats. Identities = 51/275 (18%), Positives = 106/275 (38%), Gaps = 30/275 (10%) Query: 56 KNAIIDDYKVTSQ------VLGLGINGKVLQIFNKRTQEKFALKMLQDCPKA----RREV 105 + D +++ + LG G G+ T + A+K L+ + +E Sbjct: 6 QGLAKDAWEIPRESLRLEVKLGQGCFGECWMGTWNGT-TRVAIKTLKPGTMSPEAFLQEA 64 Query: 106 ELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASE 165 ++ + + +V++ V + + IV E + G L ++ + + + Sbjct: 65 QVMKKL-RHEKLVQLYAVV-----SEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVD 118 Query: 166 IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLTTP 223 + I + Y+ +N HRD++ N+L N + K+ DFG A+ E + + Sbjct: 119 MAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLIEDNEYTARQGA 175 Query: 224 CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMG 282 + + APE ++ D+WS G+++ L G P+ + ++ Sbjct: 176 KFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---- 231 Query: 283 QYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTIT 317 Y P P E E + L+ + +P +R T Sbjct: 232 -YRMPCP--PECPESLHDLMCQCWRKDPEERPTFE 263 >4PL5-B nrPDB Length = 435 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 69/317 (21%), Positives = 131/317 (41%), Gaps = 28/317 (8%) Query: 67 SQVLGLGINGK-VLQIFNKRTQEKFALK-MLQDCPK-ARREVELHWRASQCPHIVRIVDV 123 VLG G G V + A+K +L +C A REV+L + + P+++R Sbjct: 32 KDVLGHGAEGTIVYKGM--FDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIR---- 85 Query: 124 YENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIA 183 Y R+ I +E L ++ + ++ + +LHS+NI Sbjct: 86 YFCTEKDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPI-TLLHQTTSGLAHLHSLNIV 143 Query: 184 HRDVKPENLLYTSKRPNAILK--LTDFGFAKET----TSHNSLTTPCYTPYYVAPEVLGP 237 HRD+KP N+L + + +K ++DFG K+ S + + T ++APE+L Sbjct: 144 HRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSE 203 Query: 238 EKYD---KSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSE 293 + D + D++S G + Y ++ GY PF + I +G + Sbjct: 204 DCKDNPTYTVDIFSAGCVFYYVISEGYHPFGKSLQRQ------ANILLGACNLDCFHSDK 257 Query: 294 VSEE-VKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDV 352 + + LI ++ +P QR + + HP+ K Q S ++++ V Sbjct: 258 HEDVIARELIEKMIAMDPQQRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKEALDGPIV 317 Query: 353 KEEMTSALATMRVDYEQ 369 ++ A +++D+ + Sbjct: 318 RQLERGGRAVVKMDWRE 334 >4XLV-A nrPDB Length = 328 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 69/335 (20%), Positives = 129/335 (38%), Gaps = 50/335 (14%) Query: 29 PHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTS------QVLGLGINGKVLQ-- 80 P P P P++ S + + D+++V+ + LG G G V + Sbjct: 2 PDGPLGPLFASSN--PEYLSASDVFPSSVYVPDEWEVSREKITLLRELGQGSFGMVYEGN 59 Query: 81 IFNKRTQE---KFALKMLQDCPKARREVELH-----WRASQCPHIVRIVDVYENLYAGRK 132 + E + A+K + + R +E + C H+VR++ V + + Sbjct: 60 ARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVV----SKGQ 115 Query: 133 CLLIVMECLDGGELFSRIQD--------RGDQAFTEREASEIMKSIGEAIQYLHSINIAH 184 L+VME + G+L S ++ G T +E ++ I + + YL++ H Sbjct: 116 PTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVH 175 Query: 185 RDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPC---YTPYYVAPEVLGPEKYD 241 RD+ N + + +K+ DFG ++ + ++APE L + Sbjct: 176 RDLAARNCMVAH---DFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFT 232 Query: 242 KSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 300 S DMWS GV+++ + P+ + +K + G + P+ E V Sbjct: 233 TSSDMWSFGVVLWEITSLAEQPYQGLSNEQV---LKFVMDGGYLDQPD----NCPERVTD 285 Query: 301 LIRNLLKTEPTQRMTITEFMN------HPWIMQST 329 L+R + P R T E +N HP + + Sbjct: 286 LMRMCWQFNPNMRPTFLEIVNLLKDDLHPSFPEVS 320 >4E20-A nrPDB Length = 290 Score = 211 bits (537), Expect = 5e-55, Method: Composition-based stats. Identities = 67/283 (23%), Positives = 111/283 (39%), Gaps = 35/283 (12%) Query: 62 DYKVTSQVLGLGINGKVLQ-IFN---KRTQEKFALKMLQD------CPKARREVELHWRA 111 Y + LG G GKV ++ T E A+K L++ +RE+E+ R Sbjct: 8 RYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEI-LRT 66 Query: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 HIV+ E+ G K + +VME + G L + + + I Sbjct: 67 LYHEHIVKYKGCCED--QGEKSVQLVMEYVPLGSLRDYLPRHC---VGLAQLLLFAQQIC 121 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT----TPCYTP 227 E + YLH+ + HR + N+L + R ++K+ DFG AK + Sbjct: 122 EGMAYLHAQHYIHRALAARNVLLDNDR---LVKIGDFGLAKAVPEGHEYYRVREDGDSPV 178 Query: 228 YYVAPEVLGPEKYDKSCDMWSLGVIMYILLC----GYPPFY------SNHGLAISPGMKT 277 ++ APE L K+ + D+WS GV +Y LL P + ++ T Sbjct: 179 FWYAPECLKECKFYYASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVLRLT 238 Query: 278 RIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM 320 + P P+ E+ L++N +TE + R T + Sbjct: 239 ELLERGERLPRPD--RCPCEIYHLMKNCWETEASFRPTFQNLV 279 >4H1J-A nrPDB Length = 293 Score = 211 bits (537), Expect = 5e-55, Method: Composition-based stats. Identities = 58/268 (21%), Positives = 108/268 (40%), Gaps = 29/268 (10%) Query: 65 VTSQVLGLGINGKVLQIF---NKRTQEKFALKM------LQDCPKARREVELHWRASQCP 115 V +++LG G G+V + +K + A+K L + K E + + P Sbjct: 27 VLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIM-KNLDHP 85 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 HIV+++ + E + I+ME GEL + +R + I +A+ Sbjct: 86 HIVKLIGIIE-----EEPTWIIMELYPYGELGHYL-ERNKNSLKVLTLVLYSLQICKAMA 139 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY--TPYYVAPE 233 YL SIN HRD+ N+L S +KL DFG ++ + +++PE Sbjct: 140 YLESINCVHRDIAVRNILVASPE---CVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPE 196 Query: 234 VLGPEKYDKSCDMWSLGVIMYILL-CGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWS 292 + ++ + D+W V M+ +L G PF+ + ++ R+ + + Sbjct: 197 SINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDL------ 250 Query: 293 EVSEEVKMLIRNLLKTEPTQRMTITEFM 320 + L+ +P+ R TE + Sbjct: 251 -CPPVLYTLMTRCWDYDPSDRPRFTELV 277 >3PG1-A nrPDB Length = 362 Score = 211 bits (537), Expect = 5e-55, Method: Composition-based stats. Identities = 65/325 (20%), Positives = 113/325 (34%), Gaps = 49/325 (15%) Query: 64 KVTSQVLGLGINGKVLQIFNKRTQEKFALK-------------MLQD---CPKARREVEL 107 + + G G V + A+K +L D C + RE+ L Sbjct: 24 YTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 108 HWRASQCPHIVRIVDVYENLYAGRKC-LLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 P+I+ + D++ + L +V E + +L I D+ + + Sbjct: 83 -LNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRT-DLAQVIHDQR-IVISPQHIQYF 139 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 226 M I + LH + HRD+ P N+L N + + DF A+E T+ + T Sbjct: 140 MYHILLGLHVLHEAGVVHRDLHPGNILLAD---NNDITICDFNLAREDTADANKTHYVTH 196 Query: 227 PYYVAPE-VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH------------------ 267 +Y APE V+ + + K DMWS G +M + F + Sbjct: 197 RWYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIE 256 Query: 268 --GLAISPGMKTRIRMGQYEFPNPEWSEV----SEEVKMLIRNLLKTEPTQRMTITEFMN 321 + SP + +R P W+ V LI +L+ P +R++ + + Sbjct: 257 DVVMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALR 316 Query: 322 HPWIMQSTKVPQTPLHTSRVLKEDK 346 HP+ S D+ Sbjct: 317 HPYFESLFDPLDLTEGLSERFHFDE 341 >4AN9-A nrPDB Length = 301 Score = 210 bits (536), Expect = 6e-55, Method: Composition-based stats. Identities = 66/277 (23%), Positives = 118/277 (42%), Gaps = 23/277 (8%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWRASQ---CP 115 DD++ S+ LG G G V ++ +K + A K++ + P R ++ + P Sbjct: 9 DDFEKISE-LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 67 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 +IV + + + I ME +DGG L ++ G E+ ++ ++ + + Sbjct: 68 YIVGFYGAFYS----DGEISICMEHMDGGSLDQVLKKAG--RIPEQILGKVSIAVIKGLT 121 Query: 176 YL-HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV 234 YL I HRDVKP N+L S+ +KL DFG + + T Y++PE Sbjct: 122 YLREKHKIMHRDVKPSNILVNSR---GEIKLCDFGVSGQLI-DEMANEFVGTRSYMSPER 177 Query: 235 LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 294 L Y D+WS+G+ + + G P +AI + + + P+ + Sbjct: 178 LQGTHYSVQSDIWSMGLSLVEMAVGRYP---RPPMAIFELLDYIVNEPPPKLPSAVF--- 231 Query: 295 SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKV 331 S E + + L P +R + + M H +I +S Sbjct: 232 SLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAE 268 >5U6B-A nrPDB Length = 307 Score = 210 bits (535), Expect = 8e-55, Method: Composition-based stats. Identities = 56/286 (19%), Positives = 112/286 (39%), Gaps = 29/286 (10%) Query: 56 KNAIIDDYKV-TSQVLGLGINGKVLQIFNKRTQ--EKFALKMLQDCPKARREVE------ 106 ++ ++D +KV + LG G G V++ + K A+K ++ R E+E Sbjct: 16 RDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEA 75 Query: 107 LHWRASQCPHIVRIVDVYENLYAGRKCL--LIVMECLDGGELFSRI--QDRGDQA--FTE 160 + + P+++R++ V ++++ + G+L S + GDQ Sbjct: 76 VCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPT 135 Query: 161 REASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL 220 + + M I ++YL + HRD+ N + N + + DFG +K+ + + Sbjct: 136 QMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNE---NMSVCVADFGLSKKIYNGDYY 192 Query: 221 TTPCY---TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMK 276 ++A E L Y D+WS GV M+ + G P+ I ++ Sbjct: 193 RQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLR 252 Query: 277 TRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNH 322 R+ Q ++ + + L+ + P R + TE Sbjct: 253 QGNRLKQP-------ADCLDGLYALMSRCWELNPQDRPSFTELRED 291 >4K33-A nrPDB Length = 325 Score = 210 bits (535), Expect = 9e-55, Method: Composition-based stats. Identities = 57/288 (19%), Positives = 111/288 (38%), Gaps = 45/288 (15%) Query: 66 TSQVLGLGINGKVLQI----FNKRTQEK---FALKMLQDCPKARR------EVELHWRAS 112 + LG G G+V+ +K K A+KML+D + E+E+ Sbjct: 40 LGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIG 99 Query: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGD--------------QAF 158 + +I+ ++ L +++E G L ++ R + Sbjct: 100 KHKNIINLLGAC----TQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEEQL 155 Query: 159 TEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE---TT 215 T ++ + ++YL S HRD+ N+L T + ++K+ DFG A++ Sbjct: 156 TFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE---DNVMKIADFGLARDVHNLD 212 Query: 216 SHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPG 274 + T ++APE L Y D+WS GV+++ + G P+ + Sbjct: 213 YYKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKL 272 Query: 275 MKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNH 322 +K RM + + + ++ M++R P+QR T + + Sbjct: 273 LKEGHRMDKP-------ANCTHDLYMIMRECWHAAPSQRPTFKQLVED 313 >5MJB-A nrPDB Length = 305 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 56/274 (20%), Positives = 116/274 (42%), Gaps = 30/274 (10%) Query: 63 YKVTSQVLGLGINGKVLQIFNKRTQEK---FALKMLQDCPKARREVELHWRAS-----QC 114 + +V+G G G+V + K ++ A+K L+ ++ + AS Sbjct: 27 FVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDH 86 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 +I+R+ E + + ++I+ E ++ L S ++ D FT + +++ I + Sbjct: 87 RNIIRL----EGVVTKSRPVMIITEFMENCALDSFLRQ-NDGQFTVIQLVGMLRGIAAGM 141 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS---LTTPCY---TPY 228 +YL +N HRD+ N+L S N + K++DFG ++ S T+ Sbjct: 142 KYLSEMNYVHRDLAARNILVNS---NLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVR 198 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMYI-LLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 + APE + K+ + D+WS G++M+ + G P++ + ++ Y P Sbjct: 199 WTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQ-----DYRLP 253 Query: 288 NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMN 321 P + + L+ + + + R E +N Sbjct: 254 PP--MDCPAALHQLMLDCWQKDRNSRPRFAEIVN 285 >4X7Q-B nrPDB Length = 312 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 75/293 (25%), Positives = 123/293 (41%), Gaps = 41/293 (13%) Query: 64 KVTSQVLGLGINGKVLQIFNKRTQEKFALKML-----------QDCPKARREVELHWRAS 112 +LG G G V + + A+K++ D EV L W+ Sbjct: 33 YRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVG 92 Query: 113 ---QCPHIVRIVDVYENLYAGRKCLLIVMEC-LDGGELFSRIQDRGDQAFTEREASEIMK 168 P ++R++D +E ++ ++V+E L +LF I ++G E + Sbjct: 93 AGGGHPGVIRLLDWFET----QEGFMLVLERPLPAQDLFDYITEKG--PLGEGPSRCFFG 146 Query: 169 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY 228 + AIQ+ HS + HRD+K EN+L +R KL DFG + T T Sbjct: 147 QVVAAIQHCHSRGVVHRDIKDENILIDLRR--GCAKLIDFG-SGALLHDEPYTDFDGTRV 203 Query: 229 YVAPEVLGPEKYDK-SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 Y PE + +Y +WSLG+++Y ++CG PF + I + FP Sbjct: 204 YSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQE----------ILEAELHFP 253 Query: 288 NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSR 340 + VS + LIR L +P+ R ++ E + PW+ T PL+ S+ Sbjct: 254 ----AHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQ--TPAEDVPLNPSK 300 >2J0K-A nrPDB Length = 656 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 61/277 (22%), Positives = 104/277 (37%), Gaps = 35/277 (12%) Query: 62 DYKV------TSQVLGLGINGKVLQIFNKRTQ---EKFALKMLQDC------PKARREVE 106 DY++ + +G G G V Q + A+K ++C K +E Sbjct: 384 DYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQE-A 442 Query: 107 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 L R PHIV+++ V + I+ME GEL S +Q R + Sbjct: 443 LTMRQFDHPHIVKLIGVI-----TENPVWIIMELCTLGELRSFLQVRK-FSLDLASLILY 496 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY- 225 + A+ YL S HRD+ N+L ++ +KL DFG ++ Sbjct: 497 AYQLSTALAYLESKRFVHRDIAARNVLVSATD---CVKLGDFGLSRYMEDSTYYKASKGK 553 Query: 226 -TPYYVAPEVLGPEKYDKSCDMWSLGVIMYI-LLCGYPPFYSNHGLAISPGMKTRIRMGQ 283 ++APE + ++ + D+W GV M+ L+ G PF + ++ R+ Sbjct: 554 LPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERL-- 611 Query: 284 YEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM 320 P + L+ +P++R TE Sbjct: 612 -----PMPPNCPPTLYSLMTKCWAYDPSRRPRFTELK 643 >6O6Q-A nrPDB Length = 335 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 73/323 (22%), Positives = 133/323 (41%), Gaps = 53/323 (16%) Query: 37 PPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ 96 P + ++K Q ++Y++ + LG G +V + +EK +K+L+ Sbjct: 24 PQSYWDYDDLNIKWNPQ-------ENYEILRK-LGRGKYSEVFLGIDLEKREKVVIKVLK 75 Query: 97 --DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRG 154 K +RE+ + P+I+ ++DV + L + E ++ + S Sbjct: 76 PVKRKKIKREISILKNLVDGPNIIAMLDVVREPQSKTPGL--IFEHINNIDFRSL----- 128 Query: 155 DQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET 214 FT+ + M + +A+ Y HS+ I HRDVKP N++ + +L+L D+G A+ Sbjct: 129 YPTFTDYDIRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKK--LLRLIDWGLAEYY 186 Query: 215 TSHNSLTTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISP 273 + Y+ PE+L YD S DMWS G ++ ++ PF+ HG + + Sbjct: 187 HPGTEYNVRVASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFF--HGKSNTD 244 Query: 274 GMKTRIR----------MGQYEFP------------NPEWSE---------VSEEVKMLI 302 + +R + +Y +W VS+E LI Sbjct: 245 QLVQIVRVLGSKNFKKYLEKYNISLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLI 304 Query: 303 RNLLKTEPTQRMTITEFMNHPWI 325 LL+ + +R+T E M H + Sbjct: 305 DRLLRYDHQERLTAKEAMKHAYF 327 >2DQ7-X nrPDB Length = 283 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 53/270 (19%), Positives = 109/270 (40%), Gaps = 30/270 (11%) Query: 61 DDYKV------TSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC----PKARREVELHWR 110 D +++ + LG G G+V K A+K L+ E ++ + Sbjct: 2 DVWEIPRESLQLIKRLGNGQFGEVWMGT-WNGNTKVAIKTLKPGTMSPESFLEEAQIMKK 60 Query: 111 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 + +V++ V + + IV E ++ G L ++D +A ++ + Sbjct: 61 L-KHDKLVQLYAVV-----SEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQV 114 Query: 171 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCYTPY 228 + Y+ +N HRD++ N+L + I K+ DFG A+ E + + + Sbjct: 115 AAGMAYIERMNYIHRDLRSANILVGN---GLICKIADFGLARLIEDNEYTARQGAKFPIK 171 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 + APE ++ D+WS G+++ L+ G P+ + + ++ Y P Sbjct: 172 WTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERG-----YRMP 226 Query: 288 NPEWSEVSEEVKMLIRNLLKTEPTQRMTIT 317 P+ +S + L+ + K +P +R T Sbjct: 227 CPQDCPIS--LHELMIHCWKKDPEERPTFE 254 >1JPA-A nrPDB Length = 312 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 56/271 (20%), Positives = 114/271 (42%), Gaps = 30/271 (11%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEK---FALKMLQDCPKARREVELHWRAS-----QCPHI 117 QV+G G G+V K ++ A+K L+ ++ + AS P++ Sbjct: 37 IEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNV 96 Query: 118 VRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL 177 + + E + ++I+ E ++ G L S ++ D FT + +++ I ++YL Sbjct: 97 IHL----EGVVTKSTPVMIITEFMENGSLDSFLRQ-NDGQFTVIQLVGMLRGIAAGMKYL 151 Query: 178 HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS---LTTPCY---TPYYVA 231 +N HRD+ N+L S N + K++DFG ++ S T+ + A Sbjct: 152 ADMNYVHRDLAARNILVNS---NLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 208 Query: 232 PEVLGPEKYDKSCDMWSLGVIMYI-LLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE 290 PE + K+ + D+WS G++M+ + G P++ + ++ Y P P Sbjct: 209 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQ-----DYRLPPP- 262 Query: 291 WSEVSEEVKMLIRNLLKTEPTQRMTITEFMN 321 + + L+ + + + R + +N Sbjct: 263 -MDCPSALHQLMLDCWQKDRNHRPKFGQIVN 292 >2Y6O-A nrPDB Length = 291 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 58/269 (21%), Positives = 119/269 (44%), Gaps = 28/269 (10%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEK---FALKMLQDCPKARREVELHWRAS-----QCPHI 117 +V+G+G G+V K ++ A+K L+ ++ + AS P+I Sbjct: 18 IEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNI 77 Query: 118 VRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL 177 + + V K ++I+ E ++ G L + ++ + D FT + +++ IG ++YL Sbjct: 78 IHLEGVVTKC----KPVMIITEYMENGSLDAFLR-KNDGRFTVIQLVGMLRGIGSGMKYL 132 Query: 178 HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCY--TPYYVAPE 233 ++ HRD+ N+L S N + K++DFG ++ E + TT + APE Sbjct: 133 SDMSYVHRDLAARNILVNS---NLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPE 189 Query: 234 VLGPEKYDKSCDMWSLGVIMYI-LLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWS 292 + K+ + D+WS G++M+ + G P++ + ++ Y P P Sbjct: 190 AIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEG-----YRLPPP--M 242 Query: 293 EVSEEVKMLIRNLLKTEPTQRMTITEFMN 321 + + L+ + + E + R + +N Sbjct: 243 DCPIALHQLMLDCWQKERSDRPKFGQIVN 271 >3RAW-A nrPDB Length = 381 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 72/336 (21%), Positives = 137/336 (40%), Gaps = 62/336 (18%) Query: 57 NAIIDDYKVTSQVLGLGINGKVLQIFNKRTQE-KFALKMLQDCPK----ARREVELHWRA 111 + + + Y++ LG G GKV++ + + + ALK++++ K AR E+ + + Sbjct: 47 DWLQERYEIVGN-LGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKI 105 Query: 112 SQCPHIVRIVDVY-ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 + + + V + + + I E L G F +++ Q + + + Sbjct: 106 KEKDKENKFLCVLMSDWFNFHGHMCIAFELL-GKNTFEFLKENNFQPYPLPHVRHMAYQL 164 Query: 171 GEAIQYLHSINIAHRDVKPENLLYTSKR----------------PNAILKLTDFGFAKET 214 A+++LH + H D+KPEN+L+ + N +++ DFG A T Sbjct: 165 CHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSA--T 222 Query: 215 TSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLA---- 270 H TT T +Y PEV+ + + CD+WS+G I++ G+ F ++ Sbjct: 223 FDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVM 282 Query: 271 -------ISPGMKTRIRMGQYEFP-NPEWSEVSEEVK----------------------- 299 I M R R +Y + W E S + + Sbjct: 283 MEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQL 342 Query: 300 -MLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQT 334 L+R +L+ +P QR+T+ E + HP+ T ++ Sbjct: 343 FDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERS 378 >3DKO-A nrPDB Length = 318 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 57/268 (21%), Positives = 115/268 (42%), Gaps = 28/268 (10%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEK---FALKMLQDCPKARREVELHWRAS-----QCPHI 117 +V+G G G+V K ++ A+K L+ ++ + AS P++ Sbjct: 47 IERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNV 106 Query: 118 VRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL 177 V + E + K ++IV+E ++ G L + ++ D FT + +++ I ++YL Sbjct: 107 VHL----EGVVTRGKPVMIVIEFMENGALDAFLRKH-DGQFTVIQLVGMLRGIAAGMRYL 161 Query: 178 HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCY--TPYYVAPE 233 + HRD+ N+L S N + K++DFG ++ E TT + APE Sbjct: 162 ADMGYVHRDLAARNILVNS---NLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPE 218 Query: 234 VLGPEKYDKSCDMWSLGVIMYI-LLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWS 292 + K+ + D+WS G++M+ + G P++ + ++ Y P P Sbjct: 219 AIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEG-----YRLPAP--M 271 Query: 293 EVSEEVKMLIRNLLKTEPTQRMTITEFM 320 + + L+ + + E +R + + Sbjct: 272 DCPAGLHQLMLDCWQKERAERPKFEQIV 299 >3FME-A nrPDB Length = 290 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 65/282 (23%), Positives = 109/282 (38%), Gaps = 27/282 (9%) Query: 58 AIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRA 111 DD + + LG G G V ++ + + + A+K + Q+ + ++++ R Sbjct: 4 VKADDLEPIME-LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRT 62 Query: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQD--RGDQAFTEREASEIMKS 169 CP V + I ME +D L + Q E +I S Sbjct: 63 VDCPFTVTFYGALF----REGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVS 117 Query: 170 IGEAIQYLHSI-NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY 228 I +A+++LHS ++ HRDVKP N+L + +K+ DFG + + Sbjct: 118 IVKALEHLHSKLSVIHRDVKPSNVLINAL---GQVKMCDFGISGYLVDDVAKDIDAGCKP 174 Query: 229 YVAPEVLG----PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQY 284 Y+APE + + Y D+WSLG+ M L P+ + +K + Sbjct: 175 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPY--DSWGTPFQQLKQVVEEPSP 232 Query: 285 EFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIM 326 + P + S E LK +R T E M HP+ Sbjct: 233 QLPA---DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 271 >1K9A-A nrPDB Length = 450 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 57/262 (21%), Positives = 110/262 (41%), Gaps = 25/262 (9%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARR---EVELHWRASQCPHIVRIVDVY 124 Q +G G G V+ + K A+K +++ A+ E + + + ++V+++ V Sbjct: 199 QTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQL-RHSNLVQLLGVI 255 Query: 125 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 184 + L IV E + G L ++ RG + + EA++YL N H Sbjct: 256 ---VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312 Query: 185 RDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSC 244 RD+ N+L + + + K++DFG KE +S T + APE L +K+ Sbjct: 313 RDLAARNVLVSE---DNVAKVSDFGLTKEASSTQD--TGKLPVKWTAPEALREKKFSTKS 367 Query: 245 DMWSLGVIMYIL-LCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIR 303 D+WS G++++ + G P+ + P ++ Y+ P+ V +++ Sbjct: 368 DVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-----YKMDAPD--GCPPAVYDVMK 420 Query: 304 NLLKTEPTQRMTITEF---MNH 322 N + R T + + H Sbjct: 421 NCWHLDAATRPTFLQLREQLEH 442 >5UNP-A nrPDB Length = 369 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 78/354 (22%), Positives = 147/354 (41%), Gaps = 69/354 (19%) Query: 46 FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIF-NKRTQEKFALKMLQDCPK---- 100 +HV LQ + Y++ S LG G G+V+Q ++R + ALK++++ K Sbjct: 26 YHVGDWLQ-------ERYEIVS-TLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEA 77 Query: 101 ARREVELHWRAS-QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFT 159 AR E+ + + + + P + + + + I E L G F ++D + Sbjct: 78 ARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELL-GLSTFDFLKDNNYLPYP 136 Query: 160 EREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKR----------------PNAIL 203 + + + +A+++LH + H D+KPEN+L+ + + + Sbjct: 137 IHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAV 196 Query: 204 KLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPF 263 ++ DFG A T H +T T +Y APEV+ + + CD+WS+G I++ G+ F Sbjct: 197 RVVDFGSA--TFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLF 254 Query: 264 YSNHGLA-----------ISPGMKTRIRMGQYEFP-NPEWSE------------------ 293 ++ I M + R +Y + +W E Sbjct: 255 QTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRY 314 Query: 294 VSEEVK------MLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRV 341 ++ E + LI ++L+ EP +R+T+ E + HP+ + P L S Sbjct: 315 LTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSR 368 >6GVJ-A nrPDB Length = 429 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 72/301 (23%), Positives = 130/301 (43%), Gaps = 41/301 (13%) Query: 63 YKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQC- 114 Y + Q +G G + KV Q+ N++ ++ +A+K + Q R E+ + Q Sbjct: 146 YSILKQ-IGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHS 203 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 I+R+ D + + +VME +L S ++ + ++ E K++ EA+ Sbjct: 204 DKIIRLYD----YEITDQYIYMVME-CGNIDLNSWLKKK--KSIDPWERKSYWKNMLEAV 256 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS---LTTPCYTPYYVA 231 +H I H D+KP N L + +LKL DFG A + + + T Y+ Sbjct: 257 HTIHQHGIVHSDLKPANFLIV----DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMP 312 Query: 232 PEVLGPEKYDKS-----------CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIR 280 PE + + D+WSLG I+Y + G PF + I Sbjct: 313 PEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---QQIINQISKLHAII 369 Query: 281 MGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIM-QSTKVPQTPLHTS 339 +E P+ E ++++ +++ LK +P QR++I E + HP++ Q+ V Q T+ Sbjct: 370 DPNHEIEFPDIPE--KDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGTT 427 Query: 340 R 340 Sbjct: 428 E 428 >4KIK-B nrPDB Length = 677 Score = 207 bits (528), Expect = 5e-54, Method: Composition-based stats. Identities = 75/275 (27%), Positives = 124/275 (45%), Gaps = 26/275 (9%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEKFALKMLQD--CPKARR----EVELHWRASQCPHIVR 119 + LG G G V++ N+ T E+ A+K + P+ R E+++ R + P++V Sbjct: 23 MKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLT-HPNVVA 81 Query: 120 IVDVYENL--YAGRKCLLIVMECLDGGELFSRIQD-RGDQAFTEREASEIMKSIGEAIQY 176 DV E + A L+ ME GG+L + E ++ I A++Y Sbjct: 82 ARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRY 141 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 236 LH I HRD+KPEN++ I K+ D G+AKE + T+ T Y+APE+L Sbjct: 142 LHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLE 201 Query: 237 PEKYDKSCDMWSLGVIMYILLCGYPPFYSN-HGLAISPGMKTRIR---------MGQYEF 286 +KY + D WS G + + + G+ PF N + ++ + G +F Sbjct: 202 QQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKF 261 Query: 287 ------PNPEWSEVSEEVKMLIRNLLKTEPTQRMT 315 PN S ++E ++ ++ +L P QR T Sbjct: 262 SSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGT 296 >2VWV-A nrPDB Length = 302 Score = 207 bits (528), Expect = 5e-54, Method: Composition-based stats. Identities = 60/273 (21%), Positives = 117/273 (42%), Gaps = 30/273 (10%) Query: 63 YKVTSQVLGLGINGKVLQIFNKRTQEK---FALKMLQDCPKARREVELHWRAS-----QC 114 Y +V+G G G+V + K +K A+K L+ R+ E AS + Sbjct: 17 YVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEH 76 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 P+I+R+ V N ++I+ E ++ G L S ++ D FT + +++ I + Sbjct: 77 PNIIRLEGVVTNS----MPVMILTEFMENGALDSFLR-LNDGQFTVIQLVGMLRGIASGM 131 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTT------PCYTPY 228 +YL ++ HRD+ N+L S N + K++DFG ++ ++S T Sbjct: 132 RYLAEMSYVHRDLAARNILVNS---NLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIR 188 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMYI-LLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 + APE + K+ + D WS G++M+ + G P++ + ++ Y P Sbjct: 189 WTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQ-----DYRLP 243 Query: 288 NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM 320 P + + L+ + + + R + + Sbjct: 244 PP--PDCPTSLHQLMLDCWQKDRNARPRFPQVV 274 >2R2P-A nrPDB Length = 295 Score = 207 bits (528), Expect = 5e-54, Method: Composition-based stats. Identities = 61/270 (22%), Positives = 119/270 (44%), Gaps = 30/270 (11%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEK---FALKMLQ--DCPKARR----EVELHWRASQCPH 116 +V+G G G+V K ++ A+K L+ K RR E + + P+ Sbjct: 26 IERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQ-FDHPN 84 Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 I+ + E + K ++IV E ++ G L + ++ + D FT + +++ I ++Y Sbjct: 85 IIHL----EGVVTKSKPVMIVTEYMENGSLDTFLK-KNDGQFTVIQLVGMLRGISAGMKY 139 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCY--TPYYVAP 232 L + HRD+ N+L S N + K++DFG ++ E + TT + AP Sbjct: 140 LSDMGYVHRDLAARNILINS---NLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAP 196 Query: 233 EVLGPEKYDKSCDMWSLGVIMYILL-CGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW 291 E + K+ + D+WS G++M+ ++ G P++ + ++ Y P+P Sbjct: 197 EAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEG-----YRLPSP-- 249 Query: 292 SEVSEEVKMLIRNLLKTEPTQRMTITEFMN 321 + + L+ + + E R E +N Sbjct: 250 MDCPAALYQLMLDCWQKERNSRPKFDEIVN 279 >5AMN-A nrPDB Length = 299 Score = 207 bits (528), Expect = 6e-54, Method: Composition-based stats. Identities = 61/277 (22%), Positives = 118/277 (42%), Gaps = 36/277 (12%) Query: 65 VTSQVLGLGINGKVLQI--FNKRTQE---KFALKMLQD--CPKARREVELH---WRASQC 114 V + LG G GKV++ F+ + + A+KML++ P R++ + Sbjct: 26 VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNH 85 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRG--------DQAFTEREASEI 166 PH++++ + LL+++E G L +++ ++A T + Sbjct: 86 PHVIKLYGAC----SQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISF 141 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL---TTP 223 I + +QYL + + HRD+ N+L R +K++DFG +++ +S + Sbjct: 142 AWQISQGMQYLAEMKLVHRDLAARNILVAEGRK---MKISDFGLSRDVYEEDSYVKRSQG 198 Query: 224 CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMG 282 ++A E L Y D+WS GV+++ ++ G P+ + +KT RM Sbjct: 199 RIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRME 258 Query: 283 QYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEF 319 + + SEE+ L+ K EP +R + Sbjct: 259 RPD-------NCSEEMYRLMLQCWKQEPDKRPVFADI 288 >3QUP-A nrPDB Length = 323 Score = 207 bits (528), Expect = 6e-54, Method: Composition-based stats. Identities = 61/294 (20%), Positives = 113/294 (38%), Gaps = 38/294 (12%) Query: 66 TSQVLGLGINGKVLQIFNKRTQE---KFALKMLQ-------DCPKARREVELHWRASQCP 115 ++LG G G V + K+ K A+KML+ D + RE + P Sbjct: 27 LGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACM-KEFDHP 85 Query: 116 HIVRIVDV-YENLYAGRKCL-LIVMECLDGGELFSRIQD----RGDQAFTEREASEIMKS 169 H+ ++V V + GR + ++++ + G+L + + + M Sbjct: 86 HVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFMVD 145 Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT--- 226 I ++YL S N HRD+ N + + + + DFG +++ S + C + Sbjct: 146 IACGMEYLSSRNFIHRDLAARNCMLAE---DMTVCVADFGLSRKIYSGDYYRQGCASKLP 202 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYI-LLCGYPPFYSNHGLAISPGMKTRIRMGQYE 285 ++A E L Y D+W+ GV M+ + G P+ I + R+ Q Sbjct: 203 VKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQP- 261 Query: 286 FPNPEWSEVSEEVKMLIRNLLKTEPTQRMTI-------TEFMNHPWIMQSTKVP 332 E EEV L+ +P QR + + H ++ +++ P Sbjct: 262 ------PECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGHLSVLSTSQDP 309 >5L6P-A nrPDB Length = 298 Score = 207 bits (527), Expect = 7e-54, Method: Composition-based stats. Identities = 57/271 (21%), Positives = 116/271 (42%), Gaps = 30/271 (11%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEK---FALKMLQDCPKARREVELHWRAS-----QCPHI 117 +V+G G G+V + K+ + A+K L+ R+ + AS P+I Sbjct: 23 IEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNI 82 Query: 118 VRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL 177 +R+ E + + ++I+ E ++ L S ++ D FT + +++ I ++YL Sbjct: 83 IRL----EGVVTKSRPVMILTEFMENCALDSFLR-LNDGQFTVIQLVGMLRGIAAGMKYL 137 Query: 178 HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS---LTTPCY---TPYYVA 231 +N HRD+ N+L S N + K++DFG ++ S T+ + A Sbjct: 138 SEMNYVHRDLAARNILVNS---NLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTA 194 Query: 232 PEVLGPEKYDKSCDMWSLGVIMYI-LLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE 290 PE + K+ + D+WS G++M+ + G P++ + ++ Y P P Sbjct: 195 PEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQ-----DYRLPPP- 248 Query: 291 WSEVSEEVKMLIRNLLKTEPTQRMTITEFMN 321 + + L+ + + R ++ +N Sbjct: 249 -MDCPTALHQLMLDCWVRDRNLRPKFSQIVN 278 >1BYG-A nrPDB Length = 278 Score = 207 bits (526), Expect = 1e-53, Method: Composition-based stats. Identities = 56/262 (21%), Positives = 110/262 (41%), Gaps = 25/262 (9%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARR---EVELHWRASQCPHIVRIVDVY 124 Q +G G G V+ + K A+K +++ A+ E + + + ++V+++ V Sbjct: 27 QTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQL-RHSNLVQLLGVI 83 Query: 125 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 184 + L IV E + G L ++ RG + + EA++YL N H Sbjct: 84 ---VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 140 Query: 185 RDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSC 244 RD+ N+L + + + K++DFG KE +S T + APE L +K+ Sbjct: 141 RDLAARNVLVSE---DNVAKVSDFGLTKEASSTQD--TGKLPVKWTAPEALREKKFSTKS 195 Query: 245 DMWSLGVIMYIL-LCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIR 303 D+WS G++++ + G P+ + P ++ Y+ P+ V +++ Sbjct: 196 DVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKG-----YKMDAPD--GCPPAVYEVMK 248 Query: 304 NLLKTEPTQRMTITEF---MNH 322 N + R + + + H Sbjct: 249 NCWHLDAAMRPSFLQLREQLEH 270 >5TQX-A nrPDB Length = 655 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 70/291 (24%), Positives = 120/291 (41%), Gaps = 35/291 (12%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRASQCPHIVR 119 + LG G G V ++ K A+K ++ + E+++ + ++V+ Sbjct: 12 MRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKL-NHANVVK 70 Query: 120 IVDVYENL-YAGRKCLLIVMECLDGGELFSRIQD-RGDQAFTEREASEIMKSIGEAIQYL 177 DV E L L+ ME GG+L + E + ++ IG I+YL Sbjct: 71 ACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYL 130 Query: 178 HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGP 237 H I HRD+KPEN++ I K+ D G+AK+ T T Y+APE+ Sbjct: 131 HENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAPELFEN 190 Query: 238 EKYDKSCDMWSLGVIMYILLCGYPPF-YSNHGLAISPGMKTR---------IRMGQYEF- 286 + Y + D WS G +++ + GY PF + +K + G+ F Sbjct: 191 KPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFS 250 Query: 287 -----PNPEWSEVSEEVKMLIRNLLKTEPTQR-----MTITE-----FMNH 322 PN S + E ++ ++ +L +P QR +T+ + M+H Sbjct: 251 SHLPQPNSLCSLIVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRCFVLMDH 301 >4XUF-A nrPDB Length = 297 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 55/317 (17%), Positives = 127/317 (40%), Gaps = 67/317 (21%) Query: 40 PQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFN---KRTQ--EKFALKM 94 +FP+ +++ G +VLG G GKV+ +T + A+KM Sbjct: 3 KWEFPRENLEFG----------------KVLGSGAFGKVMNATAYGISKTGVSIQVAVKM 46 Query: 95 LQDC------PKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFS 148 L++ E+++ + +IV ++ + ++ E G+L + Sbjct: 47 LKEKADSSEREALMSELKMMTQLGSHENIVNLLGAC----TLSGPIYLIFEYCCYGDLLN 102 Query: 149 RIQDRGDQAFTEREASE----------------------IMKSIGEAIQYLHSINIAHRD 186 ++ + ++ F+E E + + +++L + HRD Sbjct: 103 YLRSKREK-FSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRD 161 Query: 187 VKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTP---YYVAPEVLGPEKYDKS 243 + N+L T + ++K+ DFG A++ S ++ ++APE L Y Sbjct: 162 LAARNVLVTHGK---VVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIK 218 Query: 244 CDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI 302 D+WS G++++ + G P+ G+ + I+ G ++ P ++ +EE+ +++ Sbjct: 219 SDVWSYGILLWEIFSLGVNPY---PGIPVDANFYKLIQNG-FKMDQPFYA--TEEIYIIM 272 Query: 303 RNLLKTEPTQRMTITEF 319 ++ + +R + Sbjct: 273 QSCWAFDSRKRPSFPNL 289 >5X02-A nrPDB Length = 347 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 55/317 (17%), Positives = 127/317 (40%), Gaps = 67/317 (21%) Query: 40 PQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFN---KRTQ--EKFALKM 94 +FP+ +++ G +VLG G GKV+ +T + A+KM Sbjct: 42 KWEFPRENLEFG----------------KVLGSGAFGKVMNATAYGISKTGVSIQVAVKM 85 Query: 95 LQDC------PKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFS 148 L++ E+++ + +IV ++ + ++ E G+L + Sbjct: 86 LKEKADSSEREALMSELKMMTQLGSHENIVNLLGAC----TLSGPIYLIFEYCCYGDLLN 141 Query: 149 RIQDRGDQAFTEREASE----------------------IMKSIGEAIQYLHSINIAHRD 186 ++ + ++ F+E E + + +++L + HRD Sbjct: 142 YLRSKREK-FSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRD 200 Query: 187 VKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTP---YYVAPEVLGPEKYDKS 243 + N+L T + ++K+ DFG A++ S ++ ++APE L Y Sbjct: 201 LAARNVLVTHGK---VVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIK 257 Query: 244 CDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI 302 D+WS G++++ + G P+ G+ + I+ G ++ P ++ +EE+ +++ Sbjct: 258 SDVWSYGILLWEIFSLGVNPY---PGIPVDANFYKLIQNG-FKMDQPFYA--TEEIYIIM 311 Query: 303 RNLLKTEPTQRMTITEF 319 ++ + +R + Sbjct: 312 QSCWAFDSRKRPSFPNL 328 >2WO6-A nrPDB Length = 382 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 64/335 (19%), Positives = 135/335 (40%), Gaps = 68/335 (20%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP----KARREVELHWRASQCP 115 +D Y++ S ++G G G+V++ +++ QE A+K++++ +A+ EV L ++ Sbjct: 53 MDRYEIDS-LIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHD 111 Query: 116 HIVRIVDV-YENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 ++ V + + R L +V E L L+ +++ + + + + + A+ Sbjct: 112 TEMKYYIVHLKRHFMFRNHLCLVFEMLSY-NLYDLLRNTNFRGVSLNLTRKFAQQMCTAL 170 Query: 175 QYLH--SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAP 232 +L ++I H D+KPEN+L + + +A +K+ DFG + + + + +Y +P Sbjct: 171 LFLATPELSIIHCDLKPENILLCNPKRSA-IKIVDFGSSCQL--GQRIYQYIQSRFYRSP 227 Query: 233 EVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGM----------------- 275 EVL YD + DMWSLG I+ + G P F + + + Sbjct: 228 EVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPK 287 Query: 276 --------------KTRIRMGQYEFPNPEWSEVSE------------------------- 296 + + G+ E+ P ++ Sbjct: 288 ARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYL 347 Query: 297 EVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKV 331 + K LI +L +P R+ + H + ++ Sbjct: 348 KFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE 382 >2PL0-A nrPDB Length = 289 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 57/270 (21%), Positives = 108/270 (40%), Gaps = 30/270 (11%) Query: 61 DDYKVTSQVL------GLGINGKVLQIF-NKRTQEKFALKMLQD---CPKARREVELHWR 110 D+++V + L G G G+V + N T K A+K L+ P A + Sbjct: 16 DEWEVPRETLKLVERLGAGQFGEVWMGYYNGHT--KVAVKSLKQGSMSPDAFLAEANLMK 73 Query: 111 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 Q +VR+ V ++ + I+ E ++ G L ++ T + ++ I Sbjct: 74 QLQHQRLVRLYAVV-----TQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQI 128 Query: 171 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCYTPY 228 E + ++ N HRD++ N+L + K+ DFG A+ E + + + Sbjct: 129 AEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLIEDNEYTAREGAKFPIK 185 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 + APE + + D+WS G+++ ++ G P+ + ++ RM + + Sbjct: 186 WTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPD-- 243 Query: 288 NPEWSEVSEEVKMLIRNLLKTEPTQRMTIT 317 EE+ L+R K P R T Sbjct: 244 -----NCPEELYQLMRLCWKERPEDRPTFD 268 >3HMP-A nrPDB Length = 342 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 72/303 (23%), Positives = 131/303 (43%), Gaps = 41/303 (13%) Query: 63 YKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQC- 114 Y + Q +G G + KV Q+ N++ ++ +A+K + Q R E+ + Q Sbjct: 58 YSILKQ-IGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHS 115 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 I+R+ D + + +VME +L S ++ + ++ E K++ EA+ Sbjct: 116 DKIIRLYD----YEITDQYIYMVME-CGNIDLNSWLKKK--KSIDPWERKSYWKNMLEAV 168 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS---LTTPCYTPYYVA 231 +H I H D+KP N L + +LKL DFG A + + + T Y+ Sbjct: 169 HTIHQHGIVHSDLKPANFLIV----DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMP 224 Query: 232 PEVLGPEKYDKS-----------CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIR 280 PE + + D+WSLG I+Y + G PF + I Sbjct: 225 PEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---QQIINQISKLHAII 281 Query: 281 MGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIM-QSTKVPQTPLHTS 339 +E P+ E ++++ +++ LK +P QR++I E + HP++ Q+ V Q T+ Sbjct: 282 DPNHEIEFPDIPE--KDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGTT 339 Query: 340 RVL 342 + Sbjct: 340 EEM 342 >3A4O-X nrPDB Length = 286 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 54/277 (19%), Positives = 105/277 (37%), Gaps = 26/277 (9%) Query: 47 HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK---ARR 103 K +I + +I + LG G G+V + + K A+K L+ A Sbjct: 3 WDKDAWEIPRESIK-----LVKRLGAGQFGEVWMGYYNNS-TKVAVKTLKPGTMSVQAFL 56 Query: 104 EVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREA 163 E + Q +VR+ V + + I+ E + G L ++ + Sbjct: 57 EEANLMKTLQHDKLVRLYAVV----TREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKL 112 Query: 164 SEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLT 221 + I E + Y+ N HRD++ N+L + K+ DFG A+ E + + Sbjct: 113 IDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLM---CKIADFGLARVIEDNEYTARE 169 Query: 222 TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIR 280 + + APE + + D+WS G+++Y ++ G P+ + + R Sbjct: 170 GAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYR 229 Query: 281 MGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTIT 317 M + E +E+ +++ K + +R T Sbjct: 230 MPRVE-------NCPDELYDIMKMCWKEKAEERPTFD 259 >3QA8-A nrPDB Length = 676 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 58/207 (28%), Positives = 96/207 (46%), Gaps = 10/207 (4%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEKFALKML------QDCPKARREVELHWRASQCPHIVR 119 + LG G G VL+ ++ T E+ A+K ++ + E+++ + P++V Sbjct: 18 MKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKL-NHPNVVS 76 Query: 120 IVDVYENLYA--GRKCLLIVMECLDGGELFSRIQD-RGDQAFTEREASEIMKSIGEAIQY 176 +V + L L+ ME +GG+L + E ++ I A++Y Sbjct: 77 AREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSALRY 136 Query: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG 236 LH I HRD+KPEN++ I K+ D G+AKE T T Y+APE+L Sbjct: 137 LHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPELLE 196 Query: 237 PEKYDKSCDMWSLGVIMYILLCGYPPF 263 +KY + D WS G + + + G+ PF Sbjct: 197 QKKYTVTVDYWSFGTLAFECITGFRPF 223 >2ZMD-A nrPDB Length = 390 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 72/304 (23%), Positives = 131/304 (43%), Gaps = 41/304 (13%) Query: 63 YKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRASQC- 114 Y + Q +G G + KV Q+ N++ ++ +A+K + Q R E+ + Q Sbjct: 58 YSILKQ-IGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHS 115 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 I+R+ D + + +VME +L S ++ + ++ E K++ EA+ Sbjct: 116 DKIIRLYD----YEITDQYIYMVME-CGNIDLNSWLKKK--KSIDPWERKSYWKNMLEAV 168 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS---LTTPCYTPYYVA 231 +H I H D+KP N L + +LKL DFG A + + + Y+ Sbjct: 169 HTIHQHGIVHSDLKPANFLIV----DGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMP 224 Query: 232 PEVLGPEKYDKS-----------CDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIR 280 PE + + D+WSLG I+Y + G PF + I Sbjct: 225 PEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---QQIINQISKLHAII 281 Query: 281 MGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIM-QSTKVPQTPLHTS 339 +E P+ E ++++ +++ LK +P QR++I E + HP++ Q+ V Q T+ Sbjct: 282 DPNHEIEFPDIPE--KDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGTT 339 Query: 340 RVLK 343 +K Sbjct: 340 EEMK 343 >4PDO-A nrPDB Length = 299 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 56/267 (20%), Positives = 116/267 (43%), Gaps = 29/267 (10%) Query: 68 QVLGLGINGKVLQIFNKRTQEK----FALKMLQDCPKARREVELHWRA-----SQCPHIV 118 +V+G G G+V + K + K A+K L+ ++ V+ A +I+ Sbjct: 40 KVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNII 99 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 R+ V K ++I+ E ++ G L ++++ D F+ + +++ I ++YL Sbjct: 100 RLEGVISKY----KPMMIITEYMENGALDKFLREK-DGEFSVLQLVGMLRGIAAGMKYLA 154 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCY--TPYYVAPEV 234 ++N HRD+ N+L S N + K++DFG ++ E + TT + APE Sbjct: 155 NMNYVHRDLAARNILVNS---NLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEA 211 Query: 235 LGPEKYDKSCDMWSLGVIMYI-LLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSE 293 + K+ + D+WS G++M+ + G P++ + + + P P + Sbjct: 212 ISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDG-----FRLPTP--MD 264 Query: 294 VSEEVKMLIRNLLKTEPTQRMTITEFM 320 + L+ + E +R + + Sbjct: 265 CPSAIYQLMMQCWQQERARRPKFADIV 291 >5AP3-A nrPDB Length = 313 Score = 205 bits (521), Expect = 4e-53, Method: Composition-based stats. Identities = 70/315 (22%), Positives = 131/315 (41%), Gaps = 40/315 (12%) Query: 49 KSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKA 101 L + ++ + +G G + KV Q+ N++ ++ +A+K + Q Sbjct: 15 TENLYFQSMSVKGRIYSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSY 73 Query: 102 RREVELHWRASQC-PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTE 160 R E+ + Q I+R+ D + + +VME +L ++ + ++ Sbjct: 74 RNEIAYLNKLQQHSDKIIRLYD----YEITDQYIYMVME-CGNIDLNGWLKKK--KSIDP 126 Query: 161 REASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS- 219 E K++ EA+ +H I H D+KP N L + +LKL DFG A + + Sbjct: 127 WERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIV----DGMLKLIDFGIANQMQPDTTS 182 Query: 220 --LTTPCYTPYYVAPEVLGPEKYDKS-----------CDMWSLGVIMYILLCGYPPFYSN 266 + T Y+ PE + + D+WSLG I+Y + G PF Sbjct: 183 VVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF--- 239 Query: 267 HGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIM 326 + I +E P+ E ++++ +++ LK +P QR++I E + HP++ Sbjct: 240 QQIINQISKLHAIIDPNHEIEFPDIPE--KDLQDVLKCCLKRDPKQRISIPELLAHPYVQ 297 Query: 327 -QSTKVPQTPLHTSR 340 Q+ V Q T+ Sbjct: 298 IQTHPVNQMAKGTTE 312 >2W1I-A nrPDB Length = 326 Score = 204 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 67/285 (23%), Positives = 114/285 (40%), Gaps = 29/285 (10%) Query: 57 NAIIDDYKVTSQVLGLGINGKVLQIF----NKRTQEKFALKMLQDCPKA-----RREVEL 107 + + Q LG G G V T E A+K LQ + RE+E+ Sbjct: 36 TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEI 95 Query: 108 HWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIM 167 ++ Q +IV+ V + AGR+ L ++ME L G L +Q + + + Sbjct: 96 -LKSLQHDNIVKYKGVCYS--AGRRNLKLIMEYLPYGSLRDYLQKHK-ERIDHIKLLQYT 151 Query: 168 KSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK---ETTSHNSLTTPC 224 I + ++YL + HRD+ N+L ++ +K+ DFG K + + + P Sbjct: 152 SQICKGMEYLGTKRYIHRDLATRNILVENEN---RVKIGDFGLTKVLPQDKEYYKVKEPG 208 Query: 225 YTP-YYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-----GYPP--FYSNHGLAISPGM- 275 +P ++ APE L K+ + D+WS GV++Y L PP F G M Sbjct: 209 ESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMI 268 Query: 276 -KTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEF 319 I + + P +E+ M++ QR + + Sbjct: 269 VFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 313 >3IO7-A nrPDB Length = 313 Score = 204 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 67/285 (23%), Positives = 114/285 (40%), Gaps = 29/285 (10%) Query: 57 NAIIDDYKVTSQVLGLGINGKVLQIF----NKRTQEKFALKMLQDCPKA-----RREVEL 107 + + Q LG G G V T E A+K LQ + RE+E+ Sbjct: 23 TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEI 82 Query: 108 HWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIM 167 ++ Q +IV+ V + AGR+ L ++ME L G L +Q + + + Sbjct: 83 -LKSLQHDNIVKYKGVCYS--AGRRNLKLIMEYLPYGSLRDYLQKHK-ERIDHIKLLQYT 138 Query: 168 KSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK---ETTSHNSLTTPC 224 I + ++YL + HRD+ N+L ++ +K+ DFG K + + + P Sbjct: 139 SQICKGMEYLGTKRYIHRDLATRNILVENEN---RVKIGDFGLTKVLPQDKEYYKVKEPG 195 Query: 225 YTP-YYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-----GYPP--FYSNHGLAISPGM- 275 +P ++ APE L K+ + D+WS GV++Y L PP F G M Sbjct: 196 ESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMI 255 Query: 276 -KTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEF 319 I + + P +E+ M++ QR + + Sbjct: 256 VFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 300 >3BGP-A nrPDB Length = 333 Score = 204 bits (520), Expect = 5e-53, Method: Composition-based stats. Identities = 82/314 (26%), Positives = 125/314 (39%), Gaps = 38/314 (12%) Query: 34 QPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALK 93 H K+ ++ +LG G G V A+K Sbjct: 28 SLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIK 87 Query: 94 -----------MLQDCPKARREVELHWR-ASQCPHIVRIVDVYENLYAGRKCLLIVMECL 141 L + + EV L + +S ++R++D +E ++++E Sbjct: 88 HVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFE----RPDSFVLILERP 143 Query: 142 DG-GELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPN 200 + +LF I +RG A E A + EA+++ H+ + HRD+K EN+L R Sbjct: 144 EPVQDLFDFITERG--ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNR-- 199 Query: 201 AILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY-DKSCDMWSLGVIMYILLCG 259 LKL DFG + T T Y PE + +Y +S +WSLG+++Y ++CG Sbjct: 200 GELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCG 258 Query: 260 YPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEF 319 PF + I GQ F VS E + LIR L P+ R T E Sbjct: 259 DIPFEHDEE----------IIRGQVFFRQ----RVSSECQHLIRWCLALRPSDRPTFEEI 304 Query: 320 MNHPWIMQSTKVPQ 333 NHPW MQ +PQ Sbjct: 305 QNHPW-MQDVLLPQ 317 >3ORP-A nrPDB Length = 311 Score = 204 bits (520), Expect = 5e-53, Method: Composition-based stats. Identities = 72/291 (24%), Positives = 126/291 (43%), Gaps = 24/291 (8%) Query: 58 AIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-DCP-------KARREVELHW 109 + D Y++ ++LG G +V + R A+K+L+ D + RRE + + Sbjct: 9 HLSDRYEL-GEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQ-NA 66 Query: 110 RASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 169 A P IV + D E IVME +DG L + G T + A E++ Sbjct: 67 AALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEG--PMTPKRAIEVIAD 124 Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTP----CY 225 +A+ + H I HRDVKP N++ ++ +K+ DFG A+ + T Sbjct: 125 ACQALNFSHQNGIIHRDVKPANIMISATNA---VKVMDFGIARAIADSGNSVTQTAAVIG 181 Query: 226 TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE 285 T Y++PE + D D++SLG ++Y +L G PPF + ++++ +R Sbjct: 182 TAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVA---YQHVREDPI- 237 Query: 286 FPNPEWSEVSEEVKMLIRNLLKTEPTQRM-TITEFMNHPWIMQSTKVPQTP 335 P+ +S ++ ++ L P R T E + + + P+ P Sbjct: 238 PPSARHEGLSADLDAVVLKALAKNPENRYQTAAEMRADLVRVHNGEPPEAP 288 >2HK5-A nrPDB Length = 270 Score = 204 bits (519), Expect = 6e-53, Method: Composition-based stats. Identities = 52/260 (20%), Positives = 104/260 (40%), Gaps = 26/260 (10%) Query: 66 TSQVLGLGINGKVLQI-FNKRTQEKFALKMLQ----DCPKARREVELHWRASQCPHIVRI 120 + LG G G+V +NK T K A+K ++ E + + Q +V++ Sbjct: 19 LEKKLGAGQFGEVWMATYNKHT--KVAVKTMKPGSMSVEAFLAEANVM-KTLQHDKLVKL 75 Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 V ++ + I+ E + G L ++ + + I E + ++ Sbjct: 76 HAVV-----TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQR 130 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCYTPYYVAPEVLGPE 238 N HRD++ N+L ++ + + K+ DFG A+ E + + + + APE + Sbjct: 131 NYIHRDLRAANILVSA---SLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFG 187 Query: 239 KYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEE 297 + D+WS G+++ ++ G P+ + ++ Y P PE EE Sbjct: 188 SFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERG-----YRMPRPE--NCPEE 240 Query: 298 VKMLIRNLLKTEPTQRMTIT 317 + ++ K P +R T Sbjct: 241 LYNIMMRCWKNRPEERPTFE 260 >4LQP-A nrPDB Length = 508 Score = 203 bits (518), Expect = 7e-53, Method: Composition-based stats. Identities = 77/332 (23%), Positives = 125/332 (37%), Gaps = 87/332 (26%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRA-------SQCPHIVRI 120 +V+G G G+V + K T + +A+K L +++ H +A S P +V + Sbjct: 108 KVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSPWVVSL 167 Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 +++ + L ++ME L GG+L + + Q FTE M AI+ +H + Sbjct: 168 YYSFQDA----QYLYLIMEFLPGGDLMTMLIRW--QLFTEDVTRFYMAECILAIETIHKL 221 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFA------------KETTSHNSLTTPC---Y 225 HR +KP+N+L + +KL+DFG + K+ + T Sbjct: 222 GFIHRAIKPDNILIDIR---GHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGISKPG 278 Query: 226 T------------------------------------PYYVA------PEVLGPEKY--- 240 T +A P+ + PE + Sbjct: 279 TYNANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYIAPEIFLYQ 338 Query: 241 --DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEV 298 + CD WSLG IMY L G+PPF S +I + P+ +S E Sbjct: 339 GYGQECDWWSLGAIMYECLIGWPPFCSETP----QETYRKIMNFEQTLQFPDDIHISYEA 394 Query: 299 KMLIRNLLKTEPTQRM----TITEFMNHPWIM 326 + LIR LL QR+ E +HP+ Sbjct: 395 EDLIRRLLTH-ADQRLGRHGGADEIKSHPFFR 425 >2A1A-B nrPDB Length = 284 Score = 203 bits (517), Expect = 9e-53, Method: Composition-based stats. Identities = 65/275 (23%), Positives = 118/275 (42%), Gaps = 34/275 (12%) Query: 62 DYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-DCPKARREVELHWRASQCPHIVRI 120 D+K +++G G G+V + ++ + + +K ++ + KA REV+ + +IV Sbjct: 12 DFKEI-ELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKL-DHVNIVHY 69 Query: 121 VDVYENL------------YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMK 168 ++ + KCL I ME D G L I+ R + + A E+ + Sbjct: 70 NGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFE 129 Query: 169 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPY 228 I + + Y+HS + +RD+KP N+ + +K+ DFG + T T Sbjct: 130 QITKGVDYIHSKKLINRDLKPSNIFLVDTKQ---VKIGDFGLVTSLKNDGKRTRSKGTLR 186 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE--F 286 Y++PE + + Y K D+++LG+I+ LL + + T +R G F Sbjct: 187 YMSPEQISSQDYGKEVDLYALGLILAELL------HVCDTAFETSKFFTDLRDGIISDIF 240 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMN 321 E K L++ LL +P R +E + Sbjct: 241 DKKE--------KTLLQKLLSKKPEDRPNTSEILR 267 >3QGY-A nrPDB Length = 286 Score = 203 bits (517), Expect = 9e-53, Method: Composition-based stats. Identities = 56/274 (20%), Positives = 112/274 (40%), Gaps = 27/274 (9%) Query: 57 NAIIDDYKVT-SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR----REVELHWRA 111 + +ID ++T Q +G G G V + ++K A+K +++ + E E+ + Sbjct: 21 HMVIDPSELTFVQEIGSGQFGLVHLGY-WLNKDKVAIKTIKEGSMSEDDFIEEAEVMMKL 79 Query: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 S P +V++ V + + +V E ++ G L ++ + F + + Sbjct: 80 S-HPKLVQLYGVC----LEQAPICLVFEFMEHGCLSDYLRTQRG-LFAAETLLGMCLDVC 133 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT---PY 228 E + YL + HRD+ N L N ++K++DFG + + T+ T Sbjct: 134 EGMAYLEEACVIHRDLAARNCLVGE---NQVIKVSDFGMTR-FVLDDQYTSSTGTKFPVK 189 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 + +PEV +Y D+WS GV+M+ + G P+ + + + T R+ + Sbjct: 190 WASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRL- 248 Query: 288 NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMN 321 S V ++ + K P R + + Sbjct: 249 ------ASTHVYQIMNHCWKERPEDRPAFSRLLR 276 >1AD5-A nrPDB Length = 438 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 56/299 (18%), Positives = 111/299 (37%), Gaps = 48/299 (16%) Query: 25 TPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQI-FN 83 P + P +P + P+ +K + LG G G+V +N Sbjct: 161 VPCMSSKPQKPWEKDAWEIPRESLK----------------LEKKLGAGQFGEVWMATYN 204 Query: 84 KRTQEKFALKMLQ----DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVME 139 K T K A+K ++ E + + Q +V++ V ++ + I+ E Sbjct: 205 KHT--KVAVKTMKPGSMSVEAFLAEANVM-KTLQHDKLVKLHAVV-----TKEPIYIITE 256 Query: 140 CLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRP 199 + G L ++ + + I E + ++ N HRD++ N+L ++ Sbjct: 257 FMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA--- 313 Query: 200 NAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC- 258 + + K+ DFG A+ + + APE + + D+WS G+++ ++ Sbjct: 314 SLVCKIADFGLAR--------VGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTY 365 Query: 259 GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTIT 317 G P+ + ++ Y P PE EE+ ++ K P +R T Sbjct: 366 GRIPYPGMSNPEVIRALERG-----YRMPRPE--NCPEELYNIMMRCWKNRPEERPTFE 417 >5FM2-A nrPDB Length = 355 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 69/350 (19%), Positives = 135/350 (38%), Gaps = 63/350 (18%) Query: 19 PPPQPPTPALPHPPAQPPPPPPQQFPQFH-----VKSGLQIKKNAIIDD--YK------V 65 PP PAQ P +++ + + I++D ++ V Sbjct: 8 KPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLV 67 Query: 66 TSQVLGLGINGKVLQI--FNKRTQE---KFALKMLQD--CPKARREVELH---WRASQCP 115 + LG G GKV++ F+ + + A+KML++ P R++ + P Sbjct: 68 LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHP 127 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRG--------------------- 154 H++++ + LL+++E G L +++ Sbjct: 128 HVIKLYGAC----SQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHP 183 Query: 155 -DQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE 213 ++A T + I + +QYL + + HRD+ N+L R +K++DFG +++ Sbjct: 184 DERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRK---MKISDFGLSRD 240 Query: 214 TTSHNSL---TTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGL 269 +S + ++A E L Y D+WS GV+++ ++ G P+ Sbjct: 241 VYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPE 300 Query: 270 AISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEF 319 + +KT RM + + SEE+ L+ K EP +R + Sbjct: 301 RLFNLLKTGHRMERPD-------NCSEEMYRLMLQCWKQEPDKRPVFADI 343 >3KUL-B nrPDB Length = 325 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 64/312 (20%), Positives = 127/312 (40%), Gaps = 42/312 (13%) Query: 24 PTPALPHPP--AQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQI 81 P P P + P + F + S + I +++G G +G+V Sbjct: 21 PEPQFYAEPHTYEEPGRAGRSFTREIEASRIHI------------EKIIGSGDSGEVCYG 68 Query: 82 FNKRTQEK---FALKMLQDCPKARREVELHWRAS-----QCPHIVRIVDVYENLYAGRKC 133 + ++ A+K L+ R+ + AS P+I+R+ E + + Sbjct: 69 RLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRL----EGVVTRGRL 124 Query: 134 LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL 193 +IV E ++ G L + ++ D FT + +++ +G ++YL + HRD+ N+L Sbjct: 125 AMIVTEYMENGSLDTFLRTH-DGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVL 183 Query: 194 YTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCY--TPYYVAPEVLGPEKYDKSCDMWSL 249 S N + K++DFG ++ E + TT + APE + + + D+WS Sbjct: 184 VDS---NLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWSF 240 Query: 250 GVIMYI-LLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKT 308 GV+M+ L G P+++ + ++ Y P P + L+ + Sbjct: 241 GVVMWEVLAYGERPYWNMTNRDVISSVEEG-----YRLPAP--MGCPHALHQLMLDCWHK 293 Query: 309 EPTQRMTITEFM 320 + QR ++ + Sbjct: 294 DRAQRPRFSQIV 305 >5TUR-A nrPDB Length = 404 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 82/314 (26%), Positives = 125/314 (39%), Gaps = 38/314 (12%) Query: 34 QPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALK 93 H K+ ++ +LG G G V A+K Sbjct: 99 SLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIK 158 Query: 94 -----------MLQDCPKARREVELHWR-ASQCPHIVRIVDVYENLYAGRKCLLIVMECL 141 L + + EV L + +S ++R++D +E ++++E Sbjct: 159 HVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFE----RPDSFVLILERP 214 Query: 142 DG-GELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPN 200 + +LF I +RG A E A + EA+++ H+ + HRD+K EN+L R Sbjct: 215 EPVQDLFDFITERG--ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNR-- 270 Query: 201 AILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY-DKSCDMWSLGVIMYILLCG 259 LKL DFG + T T Y PE + +Y +S +WSLG+++Y ++CG Sbjct: 271 GELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCG 329 Query: 260 YPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEF 319 PF + I GQ F VS E + LIR L P+ R T E Sbjct: 330 DIPFEHDEE----------IIRGQVFFRQ----RVSSECQHLIRWCLALRPSDRPTFEEI 375 Query: 320 MNHPWIMQSTKVPQ 333 NHPW MQ +PQ Sbjct: 376 QNHPW-MQDVLLPQ 388 >3ZBF-A nrPDB Length = 322 Score = 202 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 59/275 (21%), Positives = 118/275 (42%), Gaps = 33/275 (12%) Query: 69 VLGLGINGKVLQIF-----NKRTQE-KFALKMLQDCPKARREVELHWRAS-----QCPHI 117 +LG G G+V + + E K A+K L+ + ++E A P+I Sbjct: 40 LLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNI 99 Query: 118 VRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAF-----TEREASEIMKSIGE 172 ++ + V + I++E ++GG+L + ++ F T + ++ I + Sbjct: 100 LKQLGVC----LLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISK 155 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNA--ILKLTDFGFAKETTSHNSLTTPC---YTP 227 YL ++ HRD+ N L + K + I+K+ DFG A++ ++ Sbjct: 156 GCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPV 215 Query: 228 YYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEF 286 ++APE L + D+WS G++++ +L G+ P+ ++ L + ++T G+ E Sbjct: 216 RWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQT---GGRLEP 272 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMN 321 P +++ L+ EP QR T + Sbjct: 273 PR----NCPDDLWNLMTQCWAQEPDQRPTFHRIQD 303 >4RC3-A nrPDB Length = 289 Score = 202 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 82/297 (27%), Positives = 126/297 (42%), Gaps = 38/297 (12%) Query: 51 GLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALK-----------MLQDCP 99 G +K+ ++ +LG G G V A+K L + Sbjct: 1 GPHMKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT 60 Query: 100 KARREVELHWR-ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDG-GELFSRIQDRGDQA 157 + EV L + +S ++R++D +E ++++E + +LF I +RG A Sbjct: 61 RVPMEVVLLKKVSSGFSGVIRLLDWFE----RPDSFVLILERPEPVQDLFDFITERG--A 114 Query: 158 FTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSH 217 E A + EA+++ H+ + HRD+K EN+L R LKL DFG + Sbjct: 115 LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNR--GELKLIDFG-SGALLKD 171 Query: 218 NSLTTPCYTPYYVAPEVLGPEKY-DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMK 276 T T Y PE + +Y +S +WSLG+++Y ++CG PF + Sbjct: 172 TVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE-------- 223 Query: 277 TRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ 333 I GQ F VS E + LIR L P+ R T E NHPW MQ +PQ Sbjct: 224 --IIRGQVFFRQ----RVSSECQHLIRWCLALRPSDRPTFEEIQNHPW-MQDVLLPQ 273 >3DLS-A nrPDB Length = 335 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 73/273 (26%), Positives = 116/273 (42%), Gaps = 39/273 (14%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQDCPKARR-------------EVELHWRASQCPH 116 LG G G V +K ++ +K ++ E+ + R + Sbjct: 32 LGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVE-HAN 90 Query: 117 IVRIVDVYENLYAGRKCLLIVME-CLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 I++++D++EN + +VME G +LF+ I E AS I + + A+ Sbjct: 91 IIKVLDIFEN----QGFFQLVMEKHGSGLDLFAFIDRH--PRLDEPLASYIFRQLVSAVG 144 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL 235 YL +I HRD+K EN++ + +KL DFG A T C T Y APEVL Sbjct: 145 YLRLKDIIHRDIKDENIVIAE---DFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVL 201 Query: 236 GPEKY-DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 294 Y +MWSLGV +Y L+ PF + ++ I V Sbjct: 202 MGNPYRGPELEMWSLGVTLYTLVFEENPFC-----ELEETVEAAIHPPYL---------V 247 Query: 295 SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 S+E+ L+ LL+ P +R T+ + + PW+ Q Sbjct: 248 SKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQ 280 >1ZXE-A nrPDB Length = 303 Score = 201 bits (512), Expect = 4e-52, Method: Composition-based stats. Identities = 70/292 (23%), Positives = 120/292 (41%), Gaps = 39/292 (13%) Query: 62 DYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE---LHWRASQCPHIV 118 D++ + VLG G G+V++ N +A+K ++ + + + + ++V Sbjct: 7 DFEEIA-VLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASLNHQYVV 65 Query: 119 RIVDVYEN---------LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 169 R + + L I ME + L+ I E + + Sbjct: 66 RYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQ-QRDEYWRLFRQ 124 Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT-------------- 215 I EA+ Y+HS I HR++KP N+ R +K+ DFG AK Sbjct: 125 ILEALSYIHSQGIIHRNLKPMNIFIDESRN---VKIGDFGLAKNVHRSLDILKLDSQNLP 181 Query: 216 -SHNSLTTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISP 273 S ++LT+ T YVA EVL G Y++ DM+SLG+I + ++ PF + Sbjct: 182 GSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY---PFSTGMERV--- 235 Query: 274 GMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 + ++R EFP + K +IR L+ +P +R +N W+ Sbjct: 236 NILKKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGWL 287 >5U6C-A nrPDB Length = 315 Score = 201 bits (511), Expect = 5e-52, Method: Composition-based stats. Identities = 57/279 (20%), Positives = 118/279 (42%), Gaps = 29/279 (10%) Query: 57 NAIIDD-YKVTSQVLGLGINGKVLQIFNKR---TQEKFALKMLQDCPKARREVELH---- 108 + +ID + ++LG G G V++ K+ T K A+K ++ ++RE+E Sbjct: 30 DVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEA 89 Query: 109 --WRASQCPHIVRIVDVY-ENLYAGRKCLLIVMECLDGGELFSRIQ----DRGDQAFTER 161 + P+++R++ V E G ++++ + G+L + + + G + + Sbjct: 90 ACMKDFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQ 149 Query: 162 EASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT 221 + M I ++YL + N HRD+ N + R + + + DFG +K+ S + Sbjct: 150 TLLKFMVDIALGMEYLSNRNFLHRDLAARNCML---RDDMTVCVADFGLSKKIYSGDYYR 206 Query: 222 TPCY---TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKT 277 ++A E L Y D+W+ GV M+ + G P+ + + Sbjct: 207 QGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLH 266 Query: 278 RIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTI 316 R+ Q E + +E+ ++ + +T+P R T Sbjct: 267 GHRLKQPE-------DCLDELYEIMYSCWRTDPLDRPTF 298 >2BUJ-A nrPDB Length = 317 Score = 201 bits (511), Expect = 5e-52, Method: Composition-based stats. Identities = 67/309 (21%), Positives = 131/309 (42%), Gaps = 33/309 (10%) Query: 55 KKNAIIDD-YKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-----QDCPKARREVELH 108 IID+ + + Q LG G V + +ALK + QD +A+RE ++H Sbjct: 21 GHMVIIDNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMH 80 Query: 109 WRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQA--FTEREASEI 166 R P+I+R+V + +++ G L++ I+ D+ TE + + Sbjct: 81 -RLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWL 139 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGF----------AKETTS 216 + I ++ +H+ AHRD+KP N+L + L D G +++ + Sbjct: 140 LLGICRGLEAIHAKGYAHRDLKPTNILLGDE---GQPVLMDLGSMNQACIHVEGSRQALT 196 Query: 217 HNSLTTPCYTPYYVAPEVLGPEKY---DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISP 273 T Y APE+ + + D+ D+WSLG ++Y ++ G P+ + Sbjct: 197 LQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYD-----MVFQ 251 Query: 274 GMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ 333 + Q + P+ S + L+ +++ +P QR I ++ +++ + P Sbjct: 252 KGDSVALAVQNQLSIPQSPRHSSALWQLLNSMMTVDPHQRPHIPLLLSQ---LEALQPPA 308 Query: 334 TPLHTSRVL 342 HT+++L Sbjct: 309 PGQHTTQIL 317 >3SXS-A nrPDB Length = 268 Score = 201 bits (511), Expect = 6e-52, Method: Composition-based stats. Identities = 52/261 (19%), Positives = 103/261 (39%), Gaps = 26/261 (9%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR----REVELHWRASQCPHIVRIVDV 123 + LG G G V + Q A+KM+++ + +E + + S P +V+ V Sbjct: 14 KELGSGQFGVVKLGK-WKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLS-HPKLVKFYGV 71 Query: 124 YENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIA 183 Y + IV E + G L + ++ G + + E+ + E + +L S Sbjct: 72 CSKEY----PIYIVTEYISNGCLLNYLRSHG-KGLEPSQLLEMCYDVCEGMAFLESHQFI 126 Query: 184 HRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT---PYYVAPEVLGPEKY 240 HRD+ N L + +K++DFG + + + T + APEV KY Sbjct: 127 HRDLAARNCLVD---RDLCVKVSDFGMTR-YVLDDQYVSSVGTKFPVKWSAPEVFHYFKY 182 Query: 241 DKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVK 299 D+W+ G++M+ + G P+ + + R+ + S+ + Sbjct: 183 SSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHL-------ASDTIY 235 Query: 300 MLIRNLLKTEPTQRMTITEFM 320 ++ + P +R T + + Sbjct: 236 QIMYSCWHELPEKRPTFQQLL 256 >5B2L-A nrPDB Length = 324 Score = 200 bits (510), Expect = 7e-52, Method: Composition-based stats. Identities = 60/285 (21%), Positives = 121/285 (42%), Gaps = 26/285 (9%) Query: 55 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ------DCPKARREVELH 108 + A I+D + ++ G G G+V ++ ++T A+K ++ + + ++++ Sbjct: 11 RYQAEINDLENLGEM-GSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVV 69 Query: 109 WRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMK 168 ++ CP+IV+ + + I ME + G +++ R ER ++ Sbjct: 70 LKSHDCPYIVQCFGTF----ITNTDVFIAMELM--GTSAEKLKKRMQGPIPERILGKMTV 123 Query: 169 SIGEAIQYL-HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTP 227 +I +A+ YL + HRDVKP N+L + +KL DFG + + T Sbjct: 124 AIVKALYYLKEKHGVIHRDVKPSNILLDER---GQIKLCDFGISGRLVDSKAKTRSAGCA 180 Query: 228 YYVAPEVLG-----PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMG 282 Y+APE + YD D+WSLG+ + L G P+ + T++ Sbjct: 181 AYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPY---KNCKTDFEVLTKVLQE 237 Query: 283 QYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 + P S + + +++ L + +R + + H +I + Sbjct: 238 EPPL-LPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKR 281 >2RIO-A nrPDB Length = 434 Score = 200 bits (510), Expect = 7e-52, Method: Composition-based stats. Identities = 70/311 (22%), Positives = 127/311 (40%), Gaps = 43/311 (13%) Query: 65 VTSQVLGLGINGKVLQIFNKRTQEKFALKM--LQDCPKARREVELHWRASQCPHIVRIVD 122 V+ ++LG G +G V+ A+K + C A E++L + P+++R Sbjct: 18 VSEKILGYGSSGTVVF-QGSFQGRPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIR--- 73 Query: 123 VYENLYAGRKCLLIVMECLDGG--ELFS--RIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 Y + L I +E + +L + D + E +++ I + +LH Sbjct: 74 -YYCSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLH 132 Query: 179 SINIAHRDVKPENLLYTSKR----------PNAILKLTDFGFAKETTSHNS-----LTTP 223 S+ I HRD+KP+N+L ++ N + ++DFG K+ S S L P Sbjct: 133 SLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNP 192 Query: 224 CYTPYYVAPEVLG-------PEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGM 275 T + APE+L + +S D++S+G + Y +L G PF Sbjct: 193 SGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDK------YSR 246 Query: 276 KTRIRMGQYEFPNPEWSE---VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVP 332 ++ I G + + + E LI ++ +P +R T + + HP +K Sbjct: 247 ESNIIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRHPLFWPKSKKL 306 Query: 333 QTPLHTSRVLK 343 + L S L+ Sbjct: 307 EFLLKVSDRLE 317 >4C59-A nrPDB Length = 340 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 70/284 (24%), Positives = 119/284 (41%), Gaps = 42/284 (14%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEKFALKML-----QDCPKARREVELHWRASQCPHIVRI 120 +VL G V + + + ++ALK L + +EV + S P+IV+ Sbjct: 31 VRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQF 90 Query: 121 VDVY----ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQ-AFTEREASEIMKSIGEAIQ 175 E G+ L++ E G+L ++ + + +I A+Q Sbjct: 91 CSAASIGKEESDTGQAEFLLLTELCK-GQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQ 149 Query: 176 YLHSIN--IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT------------ 221 ++H I HRD+K ENLL +++ +KL DFG A + + + Sbjct: 150 HMHRQKPPIIHRDLKVENLLLSNQ---GTIKLCDFGSATTISHYPDYSWSAQRRALVEEE 206 Query: 222 -TPCYTPYYVAPEVL---GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKT 277 T TP Y PE++ + D+W+LG I+Y+L PF G K Sbjct: 207 ITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFED--------GAKL 258 Query: 278 RIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMN 321 RI G+Y P P ++ + LIR +L+ P +R++I E ++ Sbjct: 259 RIVNGKYSIP-PHDTQYT-VFHSLIRAMLQVNPEERLSIAEVVH 300 >6FEX-A nrPDB Length = 321 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 53/302 (17%), Positives = 105/302 (34%), Gaps = 48/302 (15%) Query: 66 TSQVLGLGINGKVLQIF--------------NKRTQE--KFALKMLQDCPKA------RR 103 + LG G G+V N R A+K+L+ + Sbjct: 20 FKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLK 79 Query: 104 EVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDR---------- 153 EV++ R P+I+R++ V L ++ + ++ G+L + Sbjct: 80 EVKIMSRLKD-PNIIRLLGVC----VQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGA 134 Query: 154 -GDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK 212 GD + + I ++YL ++N HRD+ N L N +K+ DFG ++ Sbjct: 135 PGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGE---NFTIKIADFGMSR 191 Query: 213 ETTSHNSLTT---PCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYI--LLCGYPPFYSNH 267 + + ++A E + K+ + D+W+ GV ++ +LC PF Sbjct: 192 NLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLT 251 Query: 268 GLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 + R + + + L+ E QR ++ H ++ + Sbjct: 252 DEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQL--HRFLAE 309 Query: 328 ST 329 Sbjct: 310 DA 311 >5IKW-A nrPDB Length = 310 Score = 199 bits (507), Expect = 2e-51, Method: Composition-based stats. Identities = 71/296 (23%), Positives = 113/296 (38%), Gaps = 35/296 (11%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEKFALKML-----QDCPKARREVELHWRASQCPHIVRI 120 + L G V + + ALK + D +RE+ + S +IV Sbjct: 18 LEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGY 76 Query: 121 VDVYENLYAGRKC-LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 +D N + +LI+ME G++ +++ + FTE E +I EA+ LH Sbjct: 77 LDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQ 136 Query: 180 IN--IAHRDVKPENLLYTSKRPNAILKLTDFGFA--KETTSHNSLTTPC-------YTPY 228 I HRD+K EN+L L DFG A K T Sbjct: 137 CKTPIIHRDLKVENILLND---GGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLS 193 Query: 229 YVAPEVLG---PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE 285 Y APE++ + D+W+LG ++Y L PF +AI G Sbjct: 194 YRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF-GESQVAICDG----------N 242 Query: 286 FPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRV 341 F P+ S S + LIR +L+ +P R I + + + P + ++ S + Sbjct: 243 FTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFAFKFAAADCPVSNINNSSI 298 >3UIU-A nrPDB Length = 306 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 65/288 (22%), Positives = 118/288 (40%), Gaps = 47/288 (16%) Query: 62 DYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-DCPKARREVELHWRASQCPHIVRI 120 D+K +++G G G+V + ++ + + ++ ++ + KA REV+ + +IV Sbjct: 13 DFKEI-ELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNNEKAEREVKALAKL-DHVNIVHY 70 Query: 121 VDVYENL-------------------------YAGRKCLLIVMECLDGGELFSRIQDRGD 155 ++ + KCL I ME D G L I+ R Sbjct: 71 NGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRG 130 Query: 156 QAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT 215 + + A E+ + I + + Y+HS + HRD+KP N+ + +K+ DFG Sbjct: 131 EKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQ---VKIGDFGLVTSLK 187 Query: 216 SHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGM 275 + T T Y++PE + + Y K D+++LG+I+ LL + + Sbjct: 188 NDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL------HVCDTAFETSKF 241 Query: 276 KTRIRMGQYE--FPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMN 321 T +R G F E K L++ LL +P R +E + Sbjct: 242 FTDLRDGIISDIFDKKE--------KTLLQKLLSKKPEDRPNTSEILR 281 >4Y83-A nrPDB Length = 332 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 58/277 (20%), Positives = 116/277 (41%), Gaps = 18/277 (6%) Query: 53 QIKKNAIIDDYKVTSQVLG-----LGINGKVLQIFNKRTQEKFALKMLQDCPKARREVEL 107 QI + ++ +K+T + +G G GKV + +T+++ A K++ +VE+ Sbjct: 59 QIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEI 118 Query: 108 HWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIM 167 + +I + + + + ME +GG + +++ G E E + Sbjct: 119 QA-CFRHENIAELYGAV----LWGETVHLFMEAGEGGSVLEKLESCG--PMREFEIIWVT 171 Query: 168 KSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL-TTPCYT 226 K + + + +LHS + H D+KP N+++ S + L DFG + + T T Sbjct: 172 KHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKA----VLVDFGLSVQMTEDVYFPKDLRGT 227 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286 Y++PEV+ + D++SLG + + G PP+ + + P I Sbjct: 228 EIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPL 287 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHP 323 + + S ++ LI L+ P R + + H Sbjct: 288 EDIA-DDCSPGMRELIEASLERNPNHRPRAADLLKHE 323 >6BSD-A nrPDB Length = 876 Score = 198 bits (504), Expect = 4e-51, Method: Composition-based stats. Identities = 59/349 (16%), Positives = 114/349 (32%), Gaps = 71/349 (20%) Query: 25 TPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIF-- 82 PALP PP FP+ ++ + LG G G+V Sbjct: 551 VPALPPGAVGDGPPR-VDFPRSRLR----------------FKEKLGEGQFGEVHLCEVD 593 Query: 83 ------------NKRTQE--KFALKMLQDCPKA------RREVELHWRASQCPHIVRIVD 122 N R A+K+L+ +EV++ R P+I+R++ Sbjct: 594 SPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKD-PNIIRLLG 652 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRG-----------------DQAFTEREASE 165 V L ++ + ++ G+L + + Sbjct: 653 VC----VQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLH 708 Query: 166 IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTT--- 222 + I ++YL ++N HRD+ N L N +K+ DFG ++ + + Sbjct: 709 VAAQIASGMRYLATLNFVHRDLATRNCLVGE---NFTIKIADFGMSRNLYAGDYYRVQGR 765 Query: 223 PCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYI--LLCGYPPFYSNHGLAISPGMKTRIR 280 ++A E + K+ + D+W+ GV ++ +LC PF + R Sbjct: 766 AVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFR 825 Query: 281 MGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQST 329 + + + L+ E QR ++ H ++ + Sbjct: 826 DQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQL--HRFLAEDA 872 >4HVI-A nrPDB Length = 314 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 65/277 (23%), Positives = 102/277 (36%), Gaps = 40/277 (14%) Query: 70 LGLGINGKVLQIF----NKRTQEKFALKMLQDC-----PKARREVELHWRASQCPHIVRI 120 LG G G V T A+K LQ +RE+++ +A IV+ Sbjct: 18 LGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQI-LKALHSDFIVKY 76 Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 V + GR+ L +VME L G L +Q R I + ++YL S Sbjct: 77 RGV--SYGPGRQSLRLVMEYLPSGCLRDFLQ-RHRARLDASRLLLYSSQICKGMEYLGSR 133 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL---TTPCYTP-YYVAPEVLG 236 HRD+ N+L S+ A +K+ DFG AK P +P ++ APE L Sbjct: 134 RCVHRDLAARNILVESE---AHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLS 190 Query: 237 PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN-------- 288 + + D+WS GV++Y L + + + R+ + + P Sbjct: 191 DNIFSRQSDVWSFGVVLYELFT----YCDKSCSPSAEFL--RMMGSERDVPALSRLLELL 244 Query: 289 ------PEWSEVSEEVKMLIRNLLKTEPTQRMTITEF 319 P EV L++ P R + + Sbjct: 245 EEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSAL 281 >5TE0-A nrPDB Length = 347 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 76/322 (23%), Positives = 124/322 (38%), Gaps = 36/322 (11%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEKFALKML-----QDCPKARREVELHWRASQCPHIVRI 120 +VL G V + K ALK + D +RE+++ S +IV Sbjct: 23 VDEVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGY 81 Query: 121 VDVYENLYAGRKC--LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 +D N + +LI+M+ GG++ + + R FTE E +I EA+ LH Sbjct: 82 IDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLH 141 Query: 179 SIN--IAHRDVKPENLLYTSKRPNAILKLTDFGFA--KETTSHNSLTTPC-------YTP 227 I HRD+K EN+L + L DFG A K T Sbjct: 142 QCKTPIIHRDLKVENILLHDR---GHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTL 198 Query: 228 YYVAPEVLG---PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQY 284 Y APE++ + D+W+LG ++Y L PF +AI G Sbjct: 199 SYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF-GESQVAICDG---------- 247 Query: 285 EFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKE 344 F P+ S S+++ LIR +L+ +P +R I + + + + P + S + + Sbjct: 248 NFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAK 307 Query: 345 DKERWEDVKEEMTSALATMRVD 366 E + + R+ Sbjct: 308 LPEPVKASEAAAKKTQPKARLT 329 >5KKR-C nrPDB Length = 395 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 70/313 (22%), Positives = 122/313 (38%), Gaps = 53/313 (16%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWRASQ---CP 115 DD++ S+ LG G G V ++ +K + A K++ + P R ++ + P Sbjct: 68 DDFEKISE-LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 126 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 +IV + + + I ME +DGG L ++ G E+ ++ ++ + + Sbjct: 127 YIVGFYGAFYS----DGEISICMEHMDGGSLDQVLKKAG--RIPEQILGKVSIAVIKGLT 180 Query: 176 YL-HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV 234 YL I HRDVKP N+L S+ +KL DFG + + + + T Y++PE Sbjct: 181 YLREKHKIMHRDVKPSNILVNSR---GEIKLCDFGVSGQLIDSMA-NSFVGTRSYMSPER 236 Query: 235 LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAI----------------------- 271 L Y D+WS+G+ + + G P + Sbjct: 237 LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 296 Query: 272 ----SPGMKTRIRMGQYEF---------PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITE 318 S GM +R M +E P + S E + + L P +R + + Sbjct: 297 RPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQ 356 Query: 319 FMNHPWIMQSTKV 331 M H +I +S Sbjct: 357 LMVHAFIKRSDAE 369 >5HI2-A nrPDB Length = 283 Score = 198 bits (503), Expect = 5e-51, Method: Composition-based stats. Identities = 55/275 (20%), Positives = 116/275 (42%), Gaps = 31/275 (11%) Query: 61 DDYKV------TSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWRAS 112 DD+++ Q +G G G V + + A+KML Q + EV + + + Sbjct: 13 DDWEIPDGQITVGQRIGSGSFGTVYKG---KWHGDVAVKMLTPQQLQAFKNEVGVLRK-T 68 Query: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 + +I+ + Y+ + L IV + +G L+ + + F ++ +I + Sbjct: 69 RHVNILLFMG-----YSTKPQLAIVTQWCEGSSLYHHLHA-SETKFEMKKLIDIARQTAR 122 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFA---KETTSHNSLTTPCYTPYY 229 + YLH+ +I HRD+K N+ + +K+ DFG A + + + + Sbjct: 123 GMDYLHAKSIIHRDLKSNNIFL---HEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILW 179 Query: 230 VAPEVLGPE---KYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286 +APEV+ + Y D+++ G+++Y L+ G P+ + + + + G Sbjct: 180 MAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINN---RDQIIEMVGRGSLSP 236 Query: 287 P-NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM 320 + S + +K L+ LK + +R + + Sbjct: 237 DLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRIL 271 >6DBN-A nrPDB Length = 316 Score = 197 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 63/298 (21%), Positives = 112/298 (37%), Gaps = 35/298 (11%) Query: 49 KSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIF----NKRTQEKFALKMLQ------DC 98 K ++ + + LG G GKV T E+ A+K L+ Sbjct: 22 KPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHI 81 Query: 99 PKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAF 158 ++E+E+ R +IV+ + G + ++ME L G L + ++ Sbjct: 82 ADLKKEIEI-LRNLYHENIVKYKGICTE--DGGNGIKLIMEFLPSGSLKEYLPKNKNK-I 137 Query: 159 TEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN 218 ++ + I + + YL S HRD+ N+L S+ +K+ DFG K + Sbjct: 138 NLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQ---VKIGDFGLTKAIETDK 194 Query: 219 SLTT----PCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGY----PPFY------ 264 T ++ APE L K+ + D+WS GV ++ LL P Sbjct: 195 EYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMI 254 Query: 265 -SNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMN 321 HG + ++ G+ P P +EV L+R + +P+ R + + Sbjct: 255 GPTHGQMTVTRLVNTLKEGK-RLPCP--PNCPDEVYQLMRKCWEFQPSNRTSFQNLIE 309 >6E4F-A nrPDB Length = 290 Score = 197 bits (501), Expect = 8e-51, Method: Composition-based stats. Identities = 53/260 (20%), Positives = 109/260 (41%), Gaps = 24/260 (9%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQ---CPHIVRIVDVY 124 + LG G G V R Q A+KM+++ + E + +V++ V Sbjct: 37 KELGTGQFGVVKYGK-WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVC 95 Query: 125 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 184 ++ + I+ E + G L + +++ F ++ E+ K + EA++YL S H Sbjct: 96 ----TKQRPIFIITEYMANGCLLNYLREMR-HRFQTQQLLEMCKDVCEAMEYLESKQFLH 150 Query: 185 RDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT---PYYVAPEVLGPEKYD 241 RD+ N L + ++K++DFG ++ + T+ + + PEVL K+ Sbjct: 151 RDLAARNCLVNDQ---GVVKVSDFGLSR-YVLDDEYTSSVGSKFPVRWSPPEVLMYSKFS 206 Query: 242 KSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 300 D+W+ GV+M+ + G P+ + + +R+ + SE+V Sbjct: 207 SKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHL-------ASEKVYT 259 Query: 301 LIRNLLKTEPTQRMTITEFM 320 ++ + + +R T + Sbjct: 260 IMYSCWHEKADERPTFKILL 279 >1U59-A nrPDB Length = 287 Score = 197 bits (501), Expect = 8e-51, Method: Composition-based stats. Identities = 62/269 (23%), Positives = 113/269 (42%), Gaps = 30/269 (11%) Query: 61 DDYKVTSQVLGLGINGKVLQI--FNKRTQEKFALKMLQ------DCPKARREVELHWRAS 112 D+ + LG G G V Q ++ Q A+K+L+ D + RE ++ + Sbjct: 9 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 68 Query: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 P+IVR++ V + + L++VME GG L + + ++ +E++ + Sbjct: 69 N-PYIVRLIGVCQA-----EALMLVMEMAGGGPLHKFLVGKREE-IPVSNVAELLHQVSM 121 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTT----PCYTPY 228 ++YL N HRD+ N+L ++ K++DFG +K + +S T + Sbjct: 122 GMKYLEEKNFVHRDLAARNVLLVNRH---YAKISDFGLSKALGADDSYYTARSAGKWPLK 178 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMYI-LLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 + APE + K+ D+WS GV M+ L G P+ G + ++ RM Sbjct: 179 WYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM------ 232 Query: 288 NPEWSEVSEEVKMLIRNLLKTEPTQRMTI 316 E E+ L+ + + R Sbjct: 233 -ECPPECPPELYALMSDCWIYKWEDRPDF 260 >3EQC-A nrPDB Length = 360 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 70/313 (22%), Positives = 122/313 (38%), Gaps = 53/313 (16%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWRASQ---CP 115 DD++ S+ LG G G V ++ +K + A K++ + P R ++ + P Sbjct: 33 DDFEKISE-LGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSP 91 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 +IV + + + I ME +DGG L ++ G E+ ++ ++ + + Sbjct: 92 YIVGFYGAFYS----DGEISICMEHMDGGSLDQVLKKAG--RIPEQILGKVSIAVIKGLT 145 Query: 176 YL-HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV 234 YL I HRDVKP N+L S+ +KL DFG + + + + T Y++PE Sbjct: 146 YLREKHKIMHRDVKPSNILVNSR---GEIKLCDFGVSGQLIDSMA-NSFVGTRSYMSPER 201 Query: 235 LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAIS---------------------- 272 L Y D+WS+G+ + + G P + Sbjct: 202 LQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 261 Query: 273 -----PGMKTRIRMGQYEF-------PNPEWSE--VSEEVKMLIRNLLKTEPTQRMTITE 318 GM +R M +E P P+ S E + + L P +R + + Sbjct: 262 RPLNKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQ 321 Query: 319 FMNHPWIMQSTKV 331 M H +I +S Sbjct: 322 LMVHAFIKRSDAE 334 >4Y93-A nrPDB Length = 446 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 54/259 (20%), Positives = 108/259 (41%), Gaps = 22/259 (8%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQ---CPHIVRIVDVY 124 + LG G G V R Q A+KM+++ + E + +V++ V Sbjct: 194 KELGTGQFGVVKYGK-WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVC 252 Query: 125 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 184 ++ + I+ E + G L + +++ F ++ E+ K + EA++YL S H Sbjct: 253 ----TKQRPIFIITEYMANGCLLNYLREMR-HRFQTQQLLEMCKDVCEAMEYLESKQFLH 307 Query: 185 RDVKPENLLYTSKRPNAILKLTDFGFAKET--TSHNSLTTPCYTPYYVAPEVLGPEKYDK 242 RD+ N L + ++K++DFG + + S T + + +PEVL K+ Sbjct: 308 RDLAARNCLVNDQ---GVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLMYSKFSS 364 Query: 243 SCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKML 301 D+W+ GV+M+ + G P+ + + +R+ + SE V + Sbjct: 365 KSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHL-------ASERVYAI 417 Query: 302 IRNLLKTEPTQRMTITEFM 320 + + + +R T + Sbjct: 418 MYSCWHEKADERPTFKILL 436 >3I81-A nrPDB Length = 315 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 50/289 (17%), Positives = 113/289 (39%), Gaps = 42/289 (14%) Query: 59 IIDDYKV------TSQVLGLGINGKVLQ-----IFNKRTQEKFALKMLQDCPKARREVEL 107 + D+++V S+ LG G G V + + + + A+K + + R +E Sbjct: 9 VPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEF 68 Query: 108 H-----WRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQ------ 156 + C H+VR++ V + + L++ME + G+L S ++ + Sbjct: 69 LNEASVMKEFNCHHVVRLLGVV----SQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPV 124 Query: 157 --AFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET 214 + + ++ I + + YL++ HRD+ N + + +K+ DFG ++ Sbjct: 125 LAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI 181 Query: 215 TSHNSLTTPC---YTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLA 270 + +++PE L + D+WS GV+++ + P+ Sbjct: 182 YETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQ 241 Query: 271 ISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEF 319 + ++ + G + P+ + + L+R + P R + E Sbjct: 242 V---LRFVMEGGLLDKPD----NCPDMLFELMRMCWQYNPKMRPSFLEI 283 >5HVK-A nrPDB Length = 315 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 59/281 (20%), Positives = 113/281 (40%), Gaps = 36/281 (12%) Query: 65 VTSQVLGLGINGKVLQIFNKRTQEKFALKML-----QDCPKARREVELHWRASQCPHIVR 119 + +VLG G G+ +++ ++ T E +K L + +EV++ R + P++++ Sbjct: 17 IHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVM-RCLEHPNVLK 75 Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 + V K L + E + GG L I+ D + + K I + YLHS Sbjct: 76 FIGVLY----KDKRLNFITEYIKGGTLRGIIKSM-DSQYPWSQRVSFAKDIASGMAYLHS 130 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET---------------TSHNSLTTPC 224 +NI HR++ N L R N + + DFG A+ T Sbjct: 131 MNIIHRNLNSHNCLV---RENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVV 187 Query: 225 YTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQY 284 PY++APE++ YD+ D++S G+++ ++ + G+ R + +Y Sbjct: 188 GNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRY 247 Query: 285 EFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 P + +P +R + + + H W+ Sbjct: 248 CPP-----NCPPSFFPITVRCCDLDPEKRPSFVK-LEH-WL 281 >4XI2-A nrPDB Length = 446 Score = 194 bits (494), Expect = 5e-50, Method: Composition-based stats. Identities = 52/260 (20%), Positives = 108/260 (41%), Gaps = 24/260 (9%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQ---CPHIVRIVDVY 124 + LG G G V R Q A+KM+++ + E + +V++ V Sbjct: 193 KELGTGQFGVVKYGK-WRGQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHEKLVQLYGVC 251 Query: 125 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 184 ++ + I+ E + G L + +++ F ++ E+ K + EA++YL S H Sbjct: 252 ----TKQRPIFIITEYMANGCLLNYLREMR-HRFQTQQLLEMCKDVCEAMEYLESKQFLH 306 Query: 185 RDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT---PYYVAPEVLGPEKYD 241 RD+ N L + ++K++DFG ++ + T+ + + PEVL K+ Sbjct: 307 RDLAARNCLVNDQ---GVVKVSDFGLSR-YVLDDEYTSSVGSKFPVRWSPPEVLMYSKFS 362 Query: 242 KSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 300 D+W+ GV+M+ + G P+ + + +R+ + SE V Sbjct: 363 SKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHL-------ASERVYT 415 Query: 301 LIRNLLKTEPTQRMTITEFM 320 ++ + + +R + + Sbjct: 416 IMYSCWHEKADERPSFKILL 435 >2PVN-A nrPDB Length = 352 Score = 194 bits (494), Expect = 5e-50, Method: Composition-based stats. Identities = 77/324 (23%), Positives = 136/324 (41%), Gaps = 50/324 (15%) Query: 37 PPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ 96 P + V+ G Q DDY+V +V G G +V + N EK +K+L+ Sbjct: 35 PKEYWDYEALTVQWGEQ-------DDYEVVRKV-GRGKYSEVFEGINVNNNEKCIIKILK 86 Query: 97 DCPKARREVELHWRASQC--PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRG 154 K + + E+ + C P+IV+++D+ + ++ L + E ++ + F + Sbjct: 87 PVKKKKIKREIKILQNLCGGPNIVKLLDIVRDQHSKTPSL--IFEYVNNTD-FKVLY--- 140 Query: 155 DQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET 214 T+ + + + +A+ Y HS I HRDVKP N++ + L+L D+G A+ Sbjct: 141 -PTLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELR--KLRLIDWGLAEFY 197 Query: 215 TSHNSLTTPCYTPYYVAPEVLGP-EKYDKSCDMWSLGVIMYILLCGYPPFYSNHG----- 268 + Y+ PE+L + YD S DMWSLG + ++ PF+ H Sbjct: 198 HPGKEYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQL 257 Query: 269 --------------------LAISPGMKTRI----RMGQYEFPNPEWSE-VSEEVKMLIR 303 + + P ++ + R +F N + VS E + Sbjct: 258 VKIAKVLGTDGLNAYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLD 317 Query: 304 NLLKTEPTQRMTITEFMNHPWIMQ 327 LL+ + +R+T E M HP+ Q Sbjct: 318 KLLRYDHQERLTALEAMTHPYFQQ 341 >5HIE-A nrPDB Length = 302 Score = 194 bits (493), Expect = 7e-50, Method: Composition-based stats. Identities = 55/282 (19%), Positives = 117/282 (41%), Gaps = 31/282 (10%) Query: 54 IKKNAIIDDYKV------TSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREV 105 + + DD+++ Q +G G G V + + A+KML Q + EV Sbjct: 22 LGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKG---KWHGDVAVKMLTPQQLQAFKNEV 78 Query: 106 ELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASE 165 + + ++ +I+ + Y+ + L IV + +G L+ + + F + + Sbjct: 79 GVLRK-TRHVNILLFMG-----YSTKPQLAIVTQWCEGSSLYHHLH-IIETKFEMIKLID 131 Query: 166 IMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFA---KETTSHNSLTT 222 I + + + YLH+ +I HRD+K N+ + +K+ DFG A + + Sbjct: 132 IARQTAQGMDYLHAKSIIHRDLKSNNIFL---HEDLTVKIGDFGLATVKSRWSGSHQFEQ 188 Query: 223 PCYTPYYVAPEVLG---PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRI 279 + ++APEV+ Y D+++ G+++Y L+ G P+ + + + + Sbjct: 189 LSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINN---RDQIIFMV 245 Query: 280 RMGQYEFP-NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM 320 G + S + +K L+ LK + +R + + Sbjct: 246 GRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQIL 287 >1LUF-A nrPDB Length = 343 Score = 193 bits (492), Expect = 8e-50, Method: Composition-based stats. Identities = 55/288 (19%), Positives = 102/288 (35%), Gaps = 56/288 (19%) Query: 68 QVLGLGINGKVLQIF-------NKRTQEKFALKMLQDCPKA------RREVELHWRASQC 114 + +G G G+V Q T A+KML++ A +RE L Sbjct: 53 RDIGEGAFGRVFQARAPGLLPYEPFT--MVAVKMLKEEASADMQADFQREAALMAE-FDN 109 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDR--------------------- 153 P+IV+++ V A K + ++ E + G+L ++ Sbjct: 110 PNIVKLLGVC----AVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSS 165 Query: 154 -GDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK 212 G + E I + + + YL HRD+ N L N ++K+ DFG ++ Sbjct: 166 PGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGE---NMVVKIADFGLSR 222 Query: 213 ETTSHNSLT---TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILL-CGYPPFYSNHG 268 S + ++ PE + +Y D+W+ GV+++ + G P+Y Sbjct: 223 NIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAH 282 Query: 269 LAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTI 316 + ++ + E E+ L+R P R + Sbjct: 283 EEVIYYVRDGNILACPE-------NCPLELYNLMRLCWSKLPADRPSF 323 >6FER-A nrPDB Length = 309 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 53/298 (17%), Positives = 107/298 (35%), Gaps = 45/298 (15%) Query: 66 TSQVLGLGINGKVLQIF--------------NKRTQE--KFALKMLQ-DCPKARR----- 103 + LG G G+V + + A+KML+ D K R Sbjct: 13 FKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLK 72 Query: 104 EVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGD-------- 155 E+++ R P+I+ ++ V L ++ E ++ G+L + Sbjct: 73 EIKIMSRLKD-PNIIHLLAVC----ITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDV 127 Query: 156 QAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT 215 + + + I ++YL S+N HRD+ N L N +K+ DFG ++ Sbjct: 128 RTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVG---KNYTIKIADFGMSRNLY 184 Query: 216 SHNSLT---TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYI--LLCGYPPFYSNHGLA 270 S + +++ E + K+ + D+W+ GV ++ C P+ Sbjct: 185 SGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQ 244 Query: 271 ISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQS 328 + R + P+ + + V L+ + + + R + E H ++Q Sbjct: 245 VIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEI--HLLLLQQ 300 >5VD3-A nrPDB Length = 311 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 69/314 (21%), Positives = 116/314 (36%), Gaps = 45/314 (14%) Query: 22 QPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQI 81 + P P P F Q ++ S+ LG G G+V ++ Sbjct: 34 RGEASETLQSPGYDPSRPESFFQQS----------------FQRLSR-LGHGSYGEVFKV 76 Query: 82 FNKRTQEKFALKML-------QDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCL 134 +K +A+K +D + EV H + Q P VR+ E + L Sbjct: 77 RSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRL----EQAWEEGGIL 132 Query: 135 LIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLY 194 + E G L + G + E + ++ A+ +LHS + H DVKP N+ Sbjct: 133 YLQTELC-GPSLQQHCEAWG-ASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFL 190 Query: 195 TSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMY 254 P KL DFG E + + P Y+APE+L Y + D++SLG+ + Sbjct: 191 G---PRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQG-SYGTAADVFSLGLTIL 246 Query: 255 ILLCG-YPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQR 313 + C P + G P + +S E++ ++ +L+ +P R Sbjct: 247 EVACNMELPHGGEGWQQLRQGY----------LPPEFTAGLSSELRSVLVMMLEPDPKLR 296 Query: 314 MTITEFMNHPWIMQ 327 T + P + Q Sbjct: 297 ATAEALLALPVLRQ 310 >5HLW-A nrPDB Length = 299 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 50/268 (18%), Positives = 106/268 (39%), Gaps = 30/268 (11%) Query: 68 QVLGLGINGKVLQIFNKRTQEK---FALKMLQ------DCPKARREVELHWRASQCPHIV 118 +V+G G G V K A+K L + + E + + P+++ Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTE-GIIMKDFSHPNVL 84 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 ++ + L+V+ + G+L + I++ T ++ + + ++YL Sbjct: 85 SLLGIC---LRSEGSPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKYLA 140 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT-----PYYVAPE 233 S HRD+ N + K +K+ DFG A++ + T ++A E Sbjct: 141 SKKFVHRDLAARNCMLDEKF---TVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALE 197 Query: 234 VLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWS 292 L +K+ D+WS GV+++ L+ G PP+ + I+ + R+ Q E+ Sbjct: 198 SLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEY------ 251 Query: 293 EVSEEVKMLIRNLLKTEPTQRMTITEFM 320 + + ++ + R + +E + Sbjct: 252 -CPDPLYEVMLKCWHPKAEMRPSFSELV 278 >3LZB-A nrPDB Length = 327 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 56/265 (21%), Positives = 105/265 (39%), Gaps = 29/265 (10%) Query: 68 QVLGLGINGKVLQIFNKRTQEKF----ALKMLQD--CPKARREV---ELHWRASQCPHIV 118 +VLG G G V + EK A+K L++ PKA +E+ + PH+ Sbjct: 21 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVC 80 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 R++ + + ++ + + G L +++ D ++ I + + YL Sbjct: 81 RLLGICLTST-----VQLITQLMPFGCLLDYVREHKDNIGSQ-YLLNWCVQIAKGMNYLE 134 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY---TPYYVAPEVL 235 + HRD+ N+L + + +K+TDFG AK + ++A E + Sbjct: 135 DRRLVHRDLAARNVLVKTPQ---HVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESI 191 Query: 236 GPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 294 Y D+WS GV ++ L+ G P+ IS ++ R+ P+ Sbjct: 192 LHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERL-------PQPPIC 244 Query: 295 SEEVKMLIRNLLKTEPTQRMTITEF 319 + +V M++R + R E Sbjct: 245 TIDVYMIMRKCWMIDADSRPKFREL 269 >5GNK-A nrPDB Length = 297 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 56/265 (21%), Positives = 105/265 (39%), Gaps = 29/265 (10%) Query: 68 QVLGLGINGKVLQIFNKRTQEKF----ALKMLQD--CPKARREV---ELHWRASQCPHIV 118 +VLG G G V + EK A+K L++ PKA +E+ + PH+ Sbjct: 25 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVC 84 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 R++ + + ++M+ + G L +++ D ++ I + + YL Sbjct: 85 RLLGICLTST-----VQLIMQLMPFGCLLDYVREHKDNIGSQ-YLLNWCVQIAKGMNYLE 138 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY---TPYYVAPEVL 235 + HRD+ N+L + + +K+TDFG AK + ++A E + Sbjct: 139 DRRLVHRDLAARNVLVKTPQ---HVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESI 195 Query: 236 GPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 294 Y D+WS GV ++ L+ G P+ IS ++ R+ P+ Sbjct: 196 LHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERL-------PQPPIC 248 Query: 295 SEEVKMLIRNLLKTEPTQRMTITEF 319 + +V M++ + R E Sbjct: 249 TIDVYMIMVKCWMIDADSRPKFREL 273 >3BBT-B nrPDB Length = 328 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 55/265 (20%), Positives = 99/265 (37%), Gaps = 29/265 (10%) Query: 68 QVLGLGINGKVLQIFNKRTQEKF----ALKMLQDCPKARREVELHWRAS-----QCPHIV 118 +VLG G G V + E A+K+L + + VE A PH+V Sbjct: 21 KVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLV 80 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 R++ V + + +V + + G L + + D ++ I + + YL Sbjct: 81 RLLGVCLS-----PTIQLVTQLMPHGCLLEYVHEHKDNIGSQ-LLLNWCVQIAKGMMYLE 134 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY---TPYYVAPEVL 235 + HRD+ N+L S +K+TDFG A+ ++A E + Sbjct: 135 ERRLVHRDLAARNVLVKSPN---HVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECI 191 Query: 236 GPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 294 K+ D+WS GV ++ L+ G P+ I ++ R+ P+ Sbjct: 192 HYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERL-------PQPPIC 244 Query: 295 SEEVKMLIRNLLKTEPTQRMTITEF 319 + +V M++ + R E Sbjct: 245 TIDVYMVMVKCWMIDADSRPKFKEL 269 >6HMD-A nrPDB Length = 365 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 74/317 (23%), Positives = 135/317 (42%), Gaps = 43/317 (13%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVEL--HWRASQCPHIV 118 DDY++ + LG G +V + N E+ +K+L+ K + + E+ +I+ Sbjct: 53 DDYQLVRK-LGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNII 111 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 +++D ++ + L V E ++ + + Q T+ + M + +A+ Y H Sbjct: 112 KLIDTVKDPVSKTPAL--VFEYINNTDF-----KQLYQILTDFDIRFYMYELLKALDYCH 164 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GP 237 S I HRDVKP N++ ++ L+L D+G A+ + Y+ PE+L Sbjct: 165 SKGIMHRDVKPHNVMIDHQQK--KLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDY 222 Query: 238 EKYDKSCDMWSLGVIMYILLCGYPPFYS-----NHGLAISPGMKTRIRMG---QYEFP-N 288 + YD S DMWSLG ++ ++ PF+ + + I+ + T G +Y + Sbjct: 223 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 282 Query: 289 PEWSEV---------------------SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 P ++++ S E L+ LL+ + QR+T E M HP+ Sbjct: 283 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYP 342 Query: 328 STKVPQTPLHTSRVLKE 344 K P + VL Sbjct: 343 VVKEQSQPSADNAVLSS 359 >4JLC-A nrPDB Length = 657 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 56/237 (23%), Positives = 106/237 (44%), Gaps = 19/237 (8%) Query: 65 VTSQVLGLGINGKVLQIFNKRTQEKFALKM------LQDCPKARREVELHWRASQCPHIV 118 + S +LG G V + +K+T + +A+K+ L+ RE E+ + +IV Sbjct: 11 LLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKL-NHKNIV 69 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGD-QAFTEREASEIMKSIGEAIQYL 177 ++ + E K +++ME G L++ +++ + E E +++ + + +L Sbjct: 70 KLFAIEEETTTRHK--VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 127 Query: 178 HSINIAHRDVKPENLL-YTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL- 235 I HRD+KP N++ + ++ KLTDFG A+E + T Y+ P++ Sbjct: 128 RENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 187 Query: 236 -------GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE 285 +KY + D+WS+GV Y G PF G + + +I G+ Sbjct: 188 RAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 244 >4FL3-A nrPDB Length = 635 Score = 191 bits (485), Expect = 6e-49, Method: Composition-based stats. Identities = 65/327 (19%), Positives = 122/327 (37%), Gaps = 46/327 (14%) Query: 8 QSPPVPFPAPAPPPQ----PPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDY 63 P + A PQ P + P P + K +K ++D Sbjct: 323 YEPELAPWAADKGPQREALPMDTEVFESPFADPE-------EIRPKEVYLDRKLLTLED- 374 Query: 64 KVTSQVLGLGINGKVLQIF-----NKRTQEKFALKMLQDCPKARREVELH---WRASQCP 115 + LG G G V + + +T LK + P + E+ + P Sbjct: 375 ----KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNP 430 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 +IVR++ + E + ++VME + G L +Q ++ ++ E++ + ++ Sbjct: 431 YIVRMIGICEA-----ESWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGMK 483 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL----TTPCYTPYYVA 231 YL N HRD+ N+L ++ K++DFG +K + + T + + A Sbjct: 484 YLEESNFVHRDLAARNVLLVTQH---YAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540 Query: 232 PEVLGPEKYDKSCDMWSLGVIMYI-LLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE 290 PE + K+ D+WS GV+M+ G P+ G ++ ++ RMG Sbjct: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMG-------C 593 Query: 291 WSEVSEEVKMLIRNLLKTEPTQRMTIT 317 + E+ L+ + R Sbjct: 594 PAGCPREMYDLMNLCWTYDVENRPGFA 620 >3PLS-A nrPDB Length = 298 Score = 190 bits (484), Expect = 7e-49, Method: Composition-based stats. Identities = 48/265 (18%), Positives = 100/265 (37%), Gaps = 30/265 (11%) Query: 68 QVLGLGINGKVLQIF---NKRTQEKFALK------MLQDCPKARREVELHWRASQCPHIV 118 +V+G G G V + + + A+K +Q RE L R P+++ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLRE-GLLMRGLNHPNVL 85 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 ++ + + +++ + G+L I+ T ++ + ++YL Sbjct: 86 ALIGI---MLPPEGLPHVLLPYMCHGDLLQFIRSPQRNP-TVKDLISFGLQVARGMEYLA 141 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY-----TPYYVAPE 233 HRD+ N + +K+ DFG A++ + + + A E Sbjct: 142 EQKFVHRDLAARNCMLDESF---TVKVADFGLARDILDREYYSVQQHRHARLPVKWTALE 198 Query: 234 VLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWS 292 L ++ D+WS GV+++ LL G PP+ ++ + R P PE+ Sbjct: 199 SLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRR-----LPQPEY- 252 Query: 293 EVSEEVKMLIRNLLKTEPTQRMTIT 317 + + +++ + +P R T Sbjct: 253 -CPDSLYQVMQQCWEADPAVRPTFR 276 >4EUU-A nrPDB Length = 319 Score = 190 bits (483), Expect = 9e-49, Method: Composition-based stats. Identities = 56/248 (22%), Positives = 109/248 (43%), Gaps = 19/248 (7%) Query: 54 IKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM------LQDCPKARREVEL 107 + + + + S +LG G V + +K+T + FA+K+ L+ RE E+ Sbjct: 1 MGSQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEV 60 Query: 108 HWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQ-AFTEREASEI 166 + +IV++ + E K +++ME G L++ +++ + E E + Sbjct: 61 LKKL-NHKNIVKLFAIEEETTTRHK--VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIV 117 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLL-YTSKRPNAILKLTDFGFAKETTSHNSLTTPCY 225 ++ + + +L I HR++KP N++ + ++ KLTDFG A+E + Sbjct: 118 LRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYG 177 Query: 226 TPYYVAPEVL--------GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKT 277 T Y+ P++ +KY + D+WS+GV Y G PF G + + Sbjct: 178 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMY 237 Query: 278 RIRMGQYE 285 +I G+ Sbjct: 238 KIITGKPS 245 >3C1X-A nrPDB Length = 373 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 49/268 (18%), Positives = 106/268 (39%), Gaps = 30/268 (11%) Query: 68 QVLGLGINGKVLQIFNKRTQEK---FALKMLQ------DCPKARREVELHWRASQCPHIV 118 +V+G G G V K A+K L + + E + + P+++ Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTE-GIIMKDFSHPNVL 153 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 ++ + L+V+ + G+L + I++ T ++ + + +++L Sbjct: 154 SLLGIC---LRSEGSPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKFLA 209 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT-----PYYVAPE 233 S HRD+ N + K +K+ DFG A++ + T ++A E Sbjct: 210 SKKFVHRDLAARNCMLDEKF---TVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALE 266 Query: 234 VLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWS 292 L +K+ D+WS GV+++ L+ G PP+ + I+ + R+ Q E+ Sbjct: 267 SLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEY------ 320 Query: 293 EVSEEVKMLIRNLLKTEPTQRMTITEFM 320 + + ++ + R + +E + Sbjct: 321 -CPDPLYEVMLKCWHPKAEMRPSFSELV 347 >4EQM-A nrPDB Length = 294 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 71/282 (25%), Positives = 121/282 (42%), Gaps = 23/282 (8%) Query: 51 GLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARRE-VELHW 109 G + I + YK+ + LG G V + K A+K + P+ + E ++ Sbjct: 1 GSHMIGKIINERYKIVDK-LGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFE 59 Query: 110 RASQ------CPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREA 163 R +IV ++DV E C +VME ++G L I+ G + A Sbjct: 60 REVHNSSQLSHQNIVSMIDVDEE----DDCYYLVMEYIEGPTLSEYIESHG--PLSVDTA 113 Query: 164 SEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTP 223 I + I++ H + I HRD+KP+N+L S N LK+ DFG AK + + T Sbjct: 114 INFTNQILDGIKHAHDMRIVHRDIKPQNILIDS---NKTLKIFDFGIAKALSETSLTQTN 170 Query: 224 C--YTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRM 281 T Y +PE E D+ D++S+G+++Y +L G PPF ++I+ I+ Sbjct: 171 HVLGTVQYFSPEQAKGEATDECTDIYSIGIVLYEMLVGEPPFNGETAVSIA---IKHIQD 227 Query: 282 GQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRM-TITEFMNH 322 ++ + + +I + + R TI E + Sbjct: 228 SVPNVTTDVRKDIPQSLSNVILRATEKDKANRYKTIQEMKDD 269 >1S9I-A nrPDB Length = 354 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 68/314 (21%), Positives = 120/314 (38%), Gaps = 57/314 (18%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWRASQ---CP 115 DD++ S+ LG G G V ++ ++ + A K++ + P R ++ + P Sbjct: 16 DDFERISE-LGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSP 74 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 +IV + + + I ME +DGG L +++ + E ++ ++ + Sbjct: 75 YIVGFYGAFYS----DGEISICMEHMDGGSLDQVLKE--AKRIPEEILGKVSIAVLRGLA 128 Query: 176 YL-HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEV 234 YL I HRDVKP N+L S+ +KL DFG + + + + T Y+APE Sbjct: 129 YLREKHQIMHRDVKPSNILVNSR---GEIKLCDFGVSGQLIDSMA-NSFVGTRSYMAPER 184 Query: 235 LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAIS---------------------- 272 L Y D+WS+G+ + L G P + Sbjct: 185 LQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRP 244 Query: 273 ---------PGMKTRIRMGQYEF-------PNPEWSE--VSEEVKMLIRNLLKTEPTQRM 314 GM +R M +E P P+ + + + + L P +R Sbjct: 245 RPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERA 304 Query: 315 TITEFMNHPWIMQS 328 + NH +I +S Sbjct: 305 DLKMLTNHTFIKRS 318 >3AOX-A nrPDB Length = 344 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 53/271 (19%), Positives = 100/271 (36%), Gaps = 30/271 (11%) Query: 70 LGLGINGKVLQIF-----NKRTQEKFALKMLQDCPKARREVELHWRAS-----QCPHIVR 119 LG G G+V + N + + A+K L + + E++ A +IVR Sbjct: 55 LGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVR 114 Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQA-----FTEREASEIMKSIGEAI 174 + V I++E + GG+L S +++ + + + + I Sbjct: 115 CIGVSLQSLPR----FILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGC 170 Query: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTP---CYTPYYVA 231 QYL + HRD+ N L T P + K+ DFG A++ + ++ Sbjct: 171 QYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMP 230 Query: 232 PEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE 290 PE + D WS GV+++ + GY P+ S + + + G+ + P Sbjct: 231 PEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTS---GGRMDPP--- 284 Query: 291 WSEVSEEVKMLIRNLLKTEPTQRMTITEFMN 321 V ++ + +P R + Sbjct: 285 -KNCPGPVYRIMTQCWQHQPEDRPNFAIILE 314 >4EUT-A nrPDB Length = 396 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 56/248 (22%), Positives = 109/248 (43%), Gaps = 19/248 (7%) Query: 54 IKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM------LQDCPKARREVEL 107 + + + + S +LG G V + +K+T + FA+K+ L+ RE E+ Sbjct: 1 MGSQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEV 60 Query: 108 HWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGD-QAFTEREASEI 166 + +IV++ + E K +++ME G L++ +++ + E E + Sbjct: 61 LKKL-NHKNIVKLFAIEEETTTRHK--VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIV 117 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLL-YTSKRPNAILKLTDFGFAKETTSHNSLTTPCY 225 ++ + + +L I HR++KP N++ + ++ KLTDFG A+E + Sbjct: 118 LRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYG 177 Query: 226 TPYYVAPEVL--------GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKT 277 T Y+ P++ +KY + D+WS+GV Y G PF G + + Sbjct: 178 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMY 237 Query: 278 RIRMGQYE 285 +I G+ Sbjct: 238 KIITGKPS 245 >4MD7-E nrPDB Length = 391 Score = 188 bits (477), Expect = 5e-48, Method: Composition-based stats. Identities = 77/338 (22%), Positives = 130/338 (38%), Gaps = 50/338 (14%) Query: 21 PQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQ 80 P P + P + V+ G Q DDY++ + LG G +V + Sbjct: 4 PVPSRARVYTDVNTHRPREYWDYESHVVEWGNQ-------DDYQLVRK-LGRGKYSEVFE 55 Query: 81 IFNKRTQEKFALKMLQDCPKARREVEL--HWRASQCPHIVRIVDVYENLYAGRKCLLIVM 138 N EK +K+L+ K + + E+ P+I+ + D+ ++ + L V Sbjct: 56 AINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPAL--VF 113 Query: 139 ECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKR 198 E ++ + + Q T+ + M I +A+ Y HS+ I HRDVKP N++ + Sbjct: 114 EHVNNTDF-----KQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH 168 Query: 199 PNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILL 257 L+L D+G A+ + Y+ PE+L + YD S DMWSLG ++ ++ Sbjct: 169 R--KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI 226 Query: 258 CGYPPFYSNHG----------LAISPGMKTRIRMGQYEFPN-----------PEWSE--- 293 PF+ H + + + I E W Sbjct: 227 FRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVH 286 Query: 294 ------VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 VS E + LL+ + R+T E M HP+ Sbjct: 287 SENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 >4F0G-A nrPDB Length = 287 Score = 188 bits (477), Expect = 5e-48, Method: Composition-based stats. Identities = 59/273 (21%), Positives = 112/273 (41%), Gaps = 32/273 (11%) Query: 67 SQVLGLGINGKVLQIFNKRTQEKFALK------------MLQDCPKARREVELHWRASQC 114 + +G G G V + + + A+K M++ + +REV + Sbjct: 24 EKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNL-NH 82 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 P+IV++ + N +VME + G+L+ R+ D+ +M I I Sbjct: 83 PNIVKLYGLMHNPPR------MVMEFVPCGDLYHRLLDKA-HPIKWSVKLRLMLDIALGI 135 Query: 175 QYLHSIN--IAHRDVKPENLLYTSKRPNAIL--KLTDFGFAKETTSHNSLTTPCYTPYYV 230 +Y+ + N I HRD++ N+ S NA + K+ DFG ++++ S++ ++ Sbjct: 136 EYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVH--SVSGLLGNFQWM 193 Query: 231 APEVLG--PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN 288 APE +G E Y + D +S +I+Y +L G PF I R + P Sbjct: 194 APETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGLRPTIPE 253 Query: 289 PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMN 321 + ++ +I +P +R + + Sbjct: 254 ----DCPPRLRNVIELCWSGDPKKRPHFSYIVK 282 >3OMV-A nrPDB Length = 307 Score = 187 bits (476), Expect = 6e-48, Method: Composition-based stats. Identities = 54/266 (20%), Positives = 109/266 (40%), Gaps = 32/266 (12%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVELHWRASQCPHIVRIVD 122 +G G G V + + A+K+L+ R EV + + ++ +I+ + Sbjct: 44 IGSGSFGTVYKG---KWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRK-TRHVNILLFMG 99 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182 Y + L IV + +G L+ + + + F + +I + + + YLH+ NI Sbjct: 100 -----YMTKDNLAIVTQWCEGSSLYKHLHVQ-ETKFQMFQLIDIARQTAQGMDYLHAKNI 153 Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFA---KETTSHNSLTTPCYTPYYVAPEVLG--- 236 HRD+K N+ +K+ DFG A + + P + ++APEV+ Sbjct: 154 IHRDMKSNNIFL---HEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQD 210 Query: 237 PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN--PEWSEV 294 + D++S G+++Y L+ G P+ + M R Y P+ + Sbjct: 211 NNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGR----GYASPDLSKLYKNC 266 Query: 295 SEEVKMLIRNLLKTEPTQRMTITEFM 320 + +K L+ + +K +R + + Sbjct: 267 PKAMKRLVADCVKKVKEERPLFPQIL 292 >4HZS-A nrPDB Length = 341 Score = 187 bits (475), Expect = 8e-48, Method: Composition-based stats. Identities = 53/271 (19%), Positives = 98/271 (36%), Gaps = 33/271 (12%) Query: 62 DYKVTSQVLGLGINGKVLQIF-NKRTQEKF--ALKMLQDC--------PKARREVELHWR 110 D ++ + LG G G V + + + + A+K L+ REV Sbjct: 13 DLRLLEK-LGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAM-H 70 Query: 111 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 + +++R+ V + +V E G L R++ S + Sbjct: 71 SLDHRNLIRLYGVVLT-----PPMKMVTELAPLGSLLDRLRKHQGHFL-LGTLSRYAVQV 124 Query: 171 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTT----PCYT 226 E + YL S HRD+ NLL ++ ++K+ DFG + ++ Sbjct: 125 AEGMGYLESKRFIHRDLAARNLLLATRD---LVKIGDFGLMRALPQNDDHYVMQEHRKVP 181 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYE 285 + APE L + + D W GV ++ + G P+ +G I +I Sbjct: 182 FAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQI----LHKIDKEGER 237 Query: 286 FPNPEWSEVSEEVKMLIRNLLKTEPTQRMTI 316 P PE + +++ ++ +P R T Sbjct: 238 LPRPE--DCPQDIYNVMVQCWAHKPEDRPTF 266 >6EII-A nrPDB Length = 352 Score = 187 bits (474), Expect = 9e-48, Method: Composition-based stats. Identities = 77/338 (22%), Positives = 130/338 (38%), Gaps = 50/338 (14%) Query: 21 PQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQ 80 P P + P + V+ G Q DDY++ + LG G +V + Sbjct: 27 PVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQ-------DDYQLVRK-LGRGKYSEVFE 78 Query: 81 IFNKRTQEKFALKMLQDCPKARREVEL--HWRASQCPHIVRIVDVYENLYAGRKCLLIVM 138 N EK +K+L+ K + + E+ P+I+ + D+ ++ + L V Sbjct: 79 AINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPAL--VF 136 Query: 139 ECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKR 198 E ++ + + Q T+ + M I +A+ Y HS+ I HRDVKP N++ + Sbjct: 137 EHVNNTDF-----KQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEH 191 Query: 199 PNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILL 257 L+L D+G A+ + Y+ PE+L + YD S DMWSLG ++ ++ Sbjct: 192 R--KLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMI 249 Query: 258 CGYPPFYSNHG----------LAISPGMKTRIRMGQYEFPN-----------PEWSE--- 293 PF+ H + + + I E W Sbjct: 250 FRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVH 309 Query: 294 ------VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 VS E + LL+ + R+T E M HP+ Sbjct: 310 SENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 347 >4TPT-A nrPDB Length = 303 Score = 187 bits (474), Expect = 9e-48, Method: Composition-based stats. Identities = 56/281 (19%), Positives = 114/281 (40%), Gaps = 41/281 (14%) Query: 65 VTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC-----PKARREVELHWRASQCPHIVR 119 + +VLG G G+ +++ +K T + +K L C EV++ R+ P++++ Sbjct: 3 IHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVM-RSLDHPNVLK 61 Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 + V K L ++ E ++GG L ++ F ++ K I + YLHS Sbjct: 62 FIGVLY----KDKKLNLLTEYIEGGTLKDFLRSM--DPFPWQQKVRFAKGIASGMAYLHS 115 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET---------------------TSHN 218 + I HRD+ N L + + + + DFG ++ Sbjct: 116 MCIIHRDLNSHNCLI---KLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRK 172 Query: 219 SLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTR 278 T PY++APE+L + YD++ D++S G+++ ++ G + L + Sbjct: 173 KRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII-GQV-YADPDCLPRTLDFGLN 230 Query: 279 IRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEF 319 +++ +F ++ L + EP R ++ Sbjct: 231 VKLFWEKFVP---TDCPPAFFPLAAICCRLEPESRPAFSKL 268 >6O8B-A nrPDB Length = 665 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 56/237 (23%), Positives = 105/237 (44%), Gaps = 19/237 (8%) Query: 65 VTSQVLGLGINGKVLQIFNKRTQEKFALKM------LQDCPKARREVELHWRASQCPHIV 118 + S +LG G V + +K+T + FA+K+ L+ RE E+ + +IV Sbjct: 18 LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL-NHKNIV 76 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGD-QAFTEREASEIMKSIGEAIQYL 177 ++ + E K +++ME G L++ +++ + E E +++ + + +L Sbjct: 77 KLFAIEEETTTRHK--VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 134 Query: 178 HSINIAHRDVKPENLL-YTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL- 235 I HR++KP N++ + ++ KLTDFG A+E T Y+ P++ Sbjct: 135 RENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYE 194 Query: 236 -------GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE 285 +KY + D+WS+GV Y G PF G + + +I G+ Sbjct: 195 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 251 >4IDT-A nrPDB Length = 356 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 77/341 (22%), Positives = 124/341 (36%), Gaps = 50/341 (14%) Query: 26 PALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQV--------LGLGINGK 77 +L A + P+ G+ + + DY+ +V LG G G+ Sbjct: 30 TSLAKTWAARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGE 89 Query: 78 VLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIV 137 V ++ +K+T + A+K ++ R E + P IV + + I Sbjct: 90 VHRMEDKQTGFQCAVKKVR-LEVFRAEELMACAGLTSPRIVPLYGAVRE----GPWVNIF 144 Query: 138 MECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSK 197 ME L+GG L ++++G E A + E ++YLHS I H DVK +N+L +S Sbjct: 145 MELLEGGSLGQLVKEQG--CLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSD 202 Query: 198 RPNAILKLTDFGFAKETTSHNSLTTPC------YTPYYVAPEVLGPEKYDKSCDMWSLGV 251 +A L DFG A T ++APEV+ D D+WS Sbjct: 203 GSHAA--LCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCC 260 Query: 252 IMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKML----IRNLLK 307 +M +L G P+ + P E+ L I+ L+ Sbjct: 261 MMLHMLNGCHPW---------TQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLR 311 Query: 308 TEPTQRMTITEF-------------MNHPWIMQSTKVPQTP 335 EP R++ E + PW K P+ P Sbjct: 312 KEPIHRVSAAELGGKVNRALQQVGGLKSPW-RGEYKEPRHP 351 >6NT9-A nrPDB Length = 742 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 56/237 (23%), Positives = 106/237 (44%), Gaps = 19/237 (8%) Query: 65 VTSQVLGLGINGKVLQIFNKRTQEKFALKM------LQDCPKARREVELHWRASQCPHIV 118 + S +LG G V + +K+T + FA+K+ L+ RE E+ + +IV Sbjct: 10 LLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKL-NHKNIV 68 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGD-QAFTEREASEIMKSIGEAIQYL 177 ++ + E K +++ME G L++ +++ + E E +++ + + +L Sbjct: 69 KLFAIEEETTTRHK--VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHL 126 Query: 178 HSINIAHRDVKPENLL-YTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL- 235 I HR++KP N++ + ++ KLTDFG A+E + T Y+ P++ Sbjct: 127 RENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYE 186 Query: 236 -------GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE 285 +KY + D+WS+GV Y G PF G + + +I G+ Sbjct: 187 RAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 >2JD5-A nrPDB Length = 373 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 72/346 (20%), Positives = 126/346 (36%), Gaps = 74/346 (21%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPK----ARREVELHWRASQCP- 115 D + + LG G V + A+K+++ A E++L R + Sbjct: 18 DARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADN 77 Query: 116 ---------HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 HI++++D + + +++V E L G L + I+ + +I Sbjct: 78 TKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVL-GENLLALIKKYEHRGIPLIYVKQI 136 Query: 167 MKSIGEAIQYLHSI-NIAHRDVKPENLLY---TSKRPNAILKLTDFGFAKETTSHNSLTT 222 K + + Y+H I H D+KPEN+L S +K+ D G A H T Sbjct: 137 SKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEH--YTN 194 Query: 223 PCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLA------------ 270 T Y +PEVL + D+WS +++ L+ G F + G + Sbjct: 195 SIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQII 254 Query: 271 ----------ISPGMKTR----------------------IRMGQYEFPNPEWSEVSEEV 298 + G TR + +Y+F E E+S Sbjct: 255 ELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEIS--- 311 Query: 299 KMLIRNLLKTEPTQRMTITEFMNHPWI-----MQSTKVPQTPLHTS 339 + +L+ +P +R +NHPW+ M+ +VP L+ S Sbjct: 312 -DFLSPMLQLDPRKRADAGGLVNHPWLKDTLGMEEIRVPDRELYGS 356 >4CRL-A nrPDB Length = 406 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 72/345 (20%), Positives = 139/345 (40%), Gaps = 67/345 (19%) Query: 56 KNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEK--FALKMLQDCPKAR---REVELHWR 110 + + D ++ +G G G V + K ++ +ALK ++ + RE+ L R Sbjct: 16 RERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIAL-LR 74 Query: 111 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQ-------DRGDQAFTEREA 163 + P+++ + V+ L + + ++ + + +L+ I+ ++ Sbjct: 75 ELKHPNVISLQKVF--LSHADRKVWLLFDYAEH-DLWHIIKFHRASKANKKPVQLPRGMV 131 Query: 164 SEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPN-AILKLTDFGFAKETTSH----N 218 ++ I + I YLH+ + HRD+KP N+L + P +K+ D GFA+ S Sbjct: 132 KSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLA 191 Query: 219 SLTTPCYTPYYVAPEVLGP-EKYDKSCDMWSLGVIMYILLCGYP-------------PFY 264 L T +Y APE+L Y K+ D+W++G I LL P P++ Sbjct: 192 DLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYH 251 Query: 265 SNHGLAISPGM--------KTRIRMGQY-----EFPNPEWSEVS-------------EEV 298 + I M + +M ++ +F ++ S + Sbjct: 252 HDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKA 311 Query: 299 KMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLK 343 L++ LL +P +R+T + M P+ ++ PL TS V Sbjct: 312 FHLLQKLLTMDPIKRITSEQAMQDPYFLED------PLPTSDVFA 350 >4LRM-A nrPDB Length = 334 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 55/268 (20%), Positives = 104/268 (38%), Gaps = 32/268 (11%) Query: 68 QVLGLGINGKVLQIFNKRTQEKF----ALKMLQD--CPKARREVE----LHWRASQ--CP 115 +VLG G G V + EK A+K L++ PKA +E+ + P Sbjct: 25 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNP 84 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 H+ R++ + + ++ + + G L +++ D ++ I + + Sbjct: 85 HVCRLLGICLTST-----VQLITQLMPFGCLLDYVREHKDNIGSQ-YLLNWCVQIAKGMN 138 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY---TPYYVAP 232 YL + HRD+ N+L + + +K+TDFG AK + ++A Sbjct: 139 YLEDRRLVHRDLAARNVLVKTPQ---HVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMAL 195 Query: 233 EVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEW 291 E + Y D+WS GV ++ L+ G P+ IS ++ R+ P+ Sbjct: 196 ESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERL-------PQP 248 Query: 292 SEVSEEVKMLIRNLLKTEPTQRMTITEF 319 + +V M++ + R E Sbjct: 249 PICTIDVYMIMVKCWMIDADSRPKFREL 276 >1U54-B nrPDB Length = 291 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 53/271 (19%), Positives = 98/271 (36%), Gaps = 33/271 (12%) Query: 62 DYKVTSQVLGLGINGKVLQIF-NKRTQEKF--ALKMLQDC--------PKARREVELHWR 110 D ++ + LG G G V + + + + A+K L+ REV Sbjct: 19 DLRLLEK-LGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAM-H 76 Query: 111 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 + +++R+ V + +V E G L R++ S + Sbjct: 77 SLDHRNLIRLYGVVLT-----PPMKMVTELAPLGSLLDRLRKHQGHFL-LGTLSRYAVQV 130 Query: 171 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTT----PCYT 226 E + YL S HRD+ NLL ++ ++K+ DFG + ++ Sbjct: 131 AEGMGYLESKRFIHRDLAARNLLLATRD---LVKIGDFGLMRALPQNDDHYVMQEHRKVP 187 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYE 285 + APE L + + D W GV ++ + G P+ +G I +I Sbjct: 188 FAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQI----LHKIDKEGER 243 Query: 286 FPNPEWSEVSEEVKMLIRNLLKTEPTQRMTI 316 P PE + +++ ++ +P R T Sbjct: 244 LPRPE--DCPQDIYNVMVQCWAHKPEDRPTF 272 >3PP0-A nrPDB Length = 338 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 53/280 (18%), Positives = 109/280 (38%), Gaps = 31/280 (11%) Query: 68 QVLGLGINGKVLQIFNKRTQEKF----ALKMLQD--CPKARREV---ELHWRASQCPHIV 118 +VLG G G V + E A+K+L++ PKA +E+ P++ Sbjct: 23 KVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVS 82 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 R++ + + +V + + G L +++ + ++ I + + YL Sbjct: 83 RLLGICLTST-----VQLVTQLMPYGCLLDHVRENRGR-LGSQDLLNWCMQIAKGMSYLE 136 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCY---TPYYVAPEVL 235 + + HRD+ N+L S +K+TDFG A+ + ++A E + Sbjct: 137 DVRLVHRDLAARNVLVKSPN---HVKITDFGLARLLDIDETEYHADGGKVPIKWMALESI 193 Query: 236 GPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 294 ++ D+WS GV ++ L+ G P+ I ++ R+ P+ Sbjct: 194 LRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERL-------PQPPIC 246 Query: 295 SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQT 334 + +V M++ + R E ++ + + PQ Sbjct: 247 TIDVYMIMVKCWMIDSECRPRFRELVSE--FSRMARDPQR 284 >3HNG-A nrPDB Length = 360 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 64/379 (16%), Positives = 121/379 (31%), Gaps = 103/379 (27%) Query: 21 PQPPTPALPHPPAQPPP-PPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVL 79 P L + P +F + +K + LG G GKV+ Sbjct: 1 SMPDEVPLDEQCERLPYDASKWEFARERLK----------------LGKSLGRGAFGKVV 44 Query: 80 QI-----FNKRTQEKFALKMLQDCPKARR------EVELHWRASQCPHIVRI-------- 120 Q T A+KML++ A E+++ ++V + Sbjct: 45 QASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQG 104 Query: 121 -----------VDVYENLYAGRKCLLIV--------------ME---------------- 139 N ++ L + ME Sbjct: 105 GPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTS 164 Query: 140 ---CLDGG-----ELFSRIQDRGDQAF-----TEREASEIMKSIGEAIQYLHSINIAHRD 186 G L ++ F T + + +++L S HRD Sbjct: 165 SESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRD 224 Query: 187 VKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTP---YYVAPEVLGPEKYDKS 243 + N+L + N ++K+ DFG A++ + T ++APE + + Y Sbjct: 225 LAARNILLSE---NNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTK 281 Query: 244 CDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI 302 D+WS GV+++ + G P+ G+ + +R+R G PE+S + E+ ++ Sbjct: 282 SDVWSYGVLLWEIFSLGGSPY---PGVQMDEDFCSRLREG-MRMRAPEYS--TPEIYQIM 335 Query: 303 RNLLKTEPTQRMTITEFMN 321 + +P +R E + Sbjct: 336 LDCWHRDPKERPRFAELVE 354 >4X3F-A nrPDB Length = 337 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 69/273 (25%), Positives = 114/273 (41%), Gaps = 22/273 (8%) Query: 51 GLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWR 110 G+ + + +++ G G+V + + R + A+K+L+ + E +R Sbjct: 1 GMSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFR 60 Query: 111 -------ASQCPHIVRIVDVYENLYAGRKCL-LIVMECLDGGELFSRIQDRGDQAFTERE 162 P I + D E+ G +VME ++G L S ++ G + R Sbjct: 61 AEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTG--RLSLRH 118 Query: 163 ASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTT 222 A ++++ G A+Q H+ + HRDVKP N+L T P +K+TDFG AK + T Sbjct: 119 ALDMLEQTGRALQIAHAAGLVHRDVKPGNILIT---PTGQVKITDFGIAKAVDAAPVTQT 175 Query: 223 PC--YTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIR 280 T Y+APE + D++SLGV+ Y + G PF + L ++ I+ Sbjct: 176 GMVMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVA---MKHIK 232 Query: 281 MGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQR 313 P V + LI L P R Sbjct: 233 EPPPPLPPDLPPNV----RELIEITLVKNPAMR 261 >3LLT-A nrPDB Length = 360 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 63/335 (18%), Positives = 126/335 (37%), Gaps = 67/335 (20%) Query: 55 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARR----EVELHWR 110 KK ++++ + + +G G G+VL + ++ +A+K++++ K R E ++ + Sbjct: 28 KKGMLLNNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKK 87 Query: 111 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 + Y + + ++ E L G L+ I F + I Sbjct: 88 IQNDDINNNNIVKYHGKFMYYDHMCLIFEPL-GPSLYEIITRNNYNGFHIEDIKLYCIEI 146 Query: 171 GEAIQYLHSINIAHRDVKPENLLYTS----------------------KRPNAILKLTDF 208 +A+ YL +++ H D+KPEN+L + + +KL DF Sbjct: 147 LKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDF 206 Query: 209 GFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHG 268 G A + ++ + T Y APEV+ +D S DMWS G ++ L G F ++ Sbjct: 207 GCATFKSDYHG--SIINTRQYRAPEVILNLGWDVSSDMWSFGCVLAELYTGSLLFRTHEH 264 Query: 269 LAISPGMKTRIR--------------------MGQYEFPNPEWSE--------------- 293 + M++ I+ + + PE + Sbjct: 265 MEHLAMMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKCLPLY 324 Query: 294 ---VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 E + ++L+ +PT R + E + H ++ Sbjct: 325 KIIKHELFCDFLYSILQIDPTLRPSPAELLKHKFL 359 >5C26-A nrPDB Length = 299 Score = 181 bits (460), Expect = 4e-46, Method: Composition-based stats. Identities = 60/307 (19%), Positives = 116/307 (37%), Gaps = 42/307 (13%) Query: 24 PTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIF- 82 + P P + K +K ++D + LG G G V + + Sbjct: 1 MDTEVYESPYADPE-------EIRPKEVYLDRKLLTLED-----KELGSGNFGTVKKGYY 48 Query: 83 ----NKRTQEKFALKMLQDCPKARREVELH---WRASQCPHIVRIVDVYENLYAGRKCLL 135 +T LK + P + E+ + P+IVR++ + E + + Sbjct: 49 QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEA-----ESWM 103 Query: 136 IVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT 195 +VME + G L +Q ++ ++ E++ + ++YL N HRD+ N+L Sbjct: 104 LVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV 161 Query: 196 SKRPNAILKLTDFGFAKETTSHNSL----TTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV 251 ++ K++DFG +K + + T + + APE + K+ D+WS GV Sbjct: 162 TQH---YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGV 218 Query: 252 IMYI-LLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEP 310 +M+ G P+ G ++ ++ RMG + E+ L+ + Sbjct: 219 LMWEAFSYGQKPYRGMKGSEVTAMLEKGERMG-------CPAGCPREMYDLMNLCWTYDV 271 Query: 311 TQRMTIT 317 R Sbjct: 272 ENRPGFA 278 >4OW8-A nrPDB Length = 283 Score = 181 bits (459), Expect = 6e-46, Method: Composition-based stats. Identities = 68/267 (25%), Positives = 111/267 (41%), Gaps = 22/267 (8%) Query: 57 NAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWR------ 110 + +++ G G+V + + R + A+K+L+ + E +R Sbjct: 6 GVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTT 65 Query: 111 -ASQCPHIVRIVDVYENLYAGRKCL-LIVMECLDGGELFSRIQDRGDQAFTEREASEIMK 168 P I + D E+ G +VME ++G L S ++ G + R A ++++ Sbjct: 66 AMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTG--RLSLRHALDMLE 123 Query: 169 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPC--YT 226 G A+Q H+ + HRDVKP N+L T P +K+TDFG AK + T T Sbjct: 124 QTGRALQIAHAAGLVHRDVKPGNILIT---PTGQVKITDFGIAKAVDAAPVTQTGMVMGT 180 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286 Y+APE + D++SLGV+ Y + G PF + L ++ I+ Sbjct: 181 AQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVA---MKHIKEPPPPL 237 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQR 313 P V + LI L P R Sbjct: 238 PPDLPPNV----RELIEITLVKNPAMR 260 >6B2Q-A nrPDB Length = 317 Score = 181 bits (459), Expect = 6e-46, Method: Composition-based stats. Identities = 68/267 (25%), Positives = 111/267 (41%), Gaps = 22/267 (8%) Query: 57 NAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWR------ 110 + +++ G G+V + + R + A+K+L+ + E +R Sbjct: 27 GVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTT 86 Query: 111 -ASQCPHIVRIVDVYENLYAGRKCL-LIVMECLDGGELFSRIQDRGDQAFTEREASEIMK 168 P I + D E+ G +VME ++G L S ++ G + R A ++++ Sbjct: 87 AMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTG--RLSLRHALDMLE 144 Query: 169 SIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPC--YT 226 G A+Q H+ + HRDVKP N+L T P +K+TDFG AK + T T Sbjct: 145 QTGRALQIAHAAGLVHRDVKPGNILIT---PTGQVKITDFGIAKAVDAAPVTQTGMVMGT 201 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEF 286 Y+APE + D++SLGV+ Y + G PF + L ++ I+ Sbjct: 202 AQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVA---MKHIKEPPPPL 258 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQR 313 P V + LI L P R Sbjct: 259 PPDLPPNV----RELIEITLVKNPAMR 281 >4M7I-A nrPDB Length = 299 Score = 180 bits (458), Expect = 8e-46, Method: Composition-based stats. Identities = 67/294 (22%), Positives = 114/294 (38%), Gaps = 42/294 (14%) Query: 62 DYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD------CPKARREVELHWRASQCP 115 D++ Q LG G G V + NK +A+K ++ K REV+ + P Sbjct: 6 DFEPI-QCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLE-HP 63 Query: 116 HIVRIVDVYENLYAGRK--------CLLIVMECLDGGELFSRIQDRGDQAFTEREA-SEI 166 IVR + + K L I M+ L + R ER I Sbjct: 64 GIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHI 123 Query: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS------- 219 I EA+++LHS + HRD+KP N+ +T + ++K+ DFG Sbjct: 124 FLQIAEAVEFLHSKGLMHRDLKPSNIFFT---MDDVVKVGDFGLVTAMDQDEEEQTVLTP 180 Query: 220 ------LTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISP 273 T T Y++PE + Y D++SLG+I++ LL PF + Sbjct: 181 MPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLY---PFSTQ-----ME 232 Query: 274 GMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 ++T + +FP + E ++++++L P +R + + Sbjct: 233 RVRTLTDVRNLKFPPLFTQKYPCE-YVMVQDMLSPSPMERPEAINIIENAVFED 285 >5XVU-A nrPDB Length = 332 Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 63/300 (21%), Positives = 124/300 (41%), Gaps = 43/300 (14%) Query: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVEL--HWRASQCPHIV 118 + Y++ + +G G +V ++ A+K+L+ K + + E+ + P+I+ Sbjct: 31 NRYEIMKK-IGRGKYSEVFNGYDTECNRPCAIKVLKPVKKKKIKREIKILQNLNGGPNII 89 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 +++D+ ++ L + E ++ + + FT+++ + I +A+ Y H Sbjct: 90 KLLDIVKDPVTKTPSL--IFEYINNIDFKTL-----YPKFTDKDIRYYIYQILKALDYCH 142 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGP- 237 S I HRDVKP N++ + N ++L +G A+ + YY PE+L Sbjct: 143 SQGIMHRDVKPHNIMIDHE--NRQIRLISWGLAEFYHPGQEYNVRVASRYYKGPELLIDL 200 Query: 238 EKYDKSCDMWSLGVIMYILLCGYPPFYSNHG--------------LAISPGMKTRIRMGQ 283 + YD S D+WSLG ++ ++ PF+ H + +K + Sbjct: 201 QLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKKYNIKLK 260 Query: 284 Y-------EFPNPEWSEV---------SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 E+ WS +EV LI +L + +R+ E M HP+ + Sbjct: 261 PHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEAMEHPYFRE 320 >6DC0-A nrPDB Length = 292 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 66/252 (26%), Positives = 117/252 (46%), Gaps = 22/252 (8%) Query: 78 VLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIV 137 V + T + K+ + ++ + + +I IV+V G + Sbjct: 22 VSRALCIHTGRELRCKVFP-IKHYQDKIRPYIQLPSHSNITGIVEVI----LGETKAYVF 76 Query: 138 MECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSK 197 E D G++ S ++ R + E EA+ + K I A+ + H I D+K +++++ Sbjct: 77 FEK-DFGDMHSYVRSR--KRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTE 133 Query: 198 RPNAIL--KLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY--DKSCDMWSLGVIM 253 + L D K ++L+ P YV+PE+L K+ D+WSLGV++ Sbjct: 134 ERTQLRLESLEDTHIMK--GEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVML 191 Query: 254 YILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQR 313 Y LL G PF+ + A + ++IR GQ+ P +S + + LIR+LL+ EP++R Sbjct: 192 YTLLVGRYPFHDSDPSA----LFSKIRRGQFCIPE----HISPKARCLIRSLLRREPSER 243 Query: 314 MTITEFMNHPWI 325 +T E + HPW Sbjct: 244 LTAPEILLHPWF 255 >5CEK-A nrPDB Length = 263 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 66/252 (26%), Positives = 117/252 (46%), Gaps = 22/252 (8%) Query: 78 VLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIV 137 V + T + K+ + ++ + + +I IV+V G + Sbjct: 25 VSRALCIHTGRELRCKVFP-IKHYQDKIRPYIQLPSHSNITGIVEVI----LGETKAYVF 79 Query: 138 MECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSK 197 E D G++ S ++ R + E EA+ + K I A+ + H I D+K +++++ Sbjct: 80 FEK-DFGDMHSYVRSR--KRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTE 136 Query: 198 RPNAIL--KLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY--DKSCDMWSLGVIM 253 + L D K ++L+ P YV+PE+L K+ D+WSLGV++ Sbjct: 137 ERTQLRLESLEDTHIMK--GEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVML 194 Query: 254 YILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQR 313 Y LL G PF+ + A + ++IR GQ+ P +S + + LIR+LL+ EP++R Sbjct: 195 YTLLVGRYPFHDSDPSA----LFSKIRRGQFCIPE----HISPKARCLIRSLLRREPSER 246 Query: 314 MTITEFMNHPWI 325 +T E + HPW Sbjct: 247 LTAPEILLHPWF 258 >5WNO-A nrPDB Length = 330 Score = 178 bits (453), Expect = 3e-45, Method: Composition-based stats. Identities = 57/298 (19%), Positives = 106/298 (35%), Gaps = 29/298 (9%) Query: 66 TSQVLGLGINGKVLQI-----FNKRTQEKFALKMLQDCPKARREV---ELHWRASQCPHI 117 + LG G G V K + A+K+ Q E+ + + ++ Sbjct: 26 LDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNL 85 Query: 118 VRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL 177 ++I+ L IV G L + ++ + RE I +QYL Sbjct: 86 LKIIGFC----MHDDGLKIVTIYRPLGNLQNFLKLHKEN-LGAREQVLYCYQIASGMQYL 140 Query: 178 HSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS---LTTPCYTPYYVAPEV 234 + HRD+ N+L + +++TDFG +K + + ++A E+ Sbjct: 141 EKQRVVHRDLATRNVLV---KKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEI 197 Query: 235 LGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSE 293 Y + D+W+ GV + ++ G P+ +I +K R+ Q Sbjct: 198 FSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQP-------PN 250 Query: 294 VSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWED 351 S+++ + +P R E + + KVPQ L S + E E+ Sbjct: 251 CSQDLYQELLRCWMADPKSRPGF-EILY-ERFKEFCKVPQLFLENSNKISESDLSAEE 306 >4IAN-A nrPDB Length = 358 Score = 177 bits (450), Expect = 5e-45, Method: Composition-based stats. Identities = 72/342 (21%), Positives = 138/342 (40%), Gaps = 71/342 (20%) Query: 49 KSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNK-RTQEKFALKMLQDCPKARR---- 103 + ++ ++D G G+ V++ + R ++ A+K++++ ++ Sbjct: 17 EGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLK 76 Query: 104 EVELHWRASQCP-----HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRG-DQA 157 E+E + + H +R+ + + ++ L +V E L L ++ G D Sbjct: 77 ELEFLKKLNDADPDDKFHCLRLFRHFYH----KQHLCLVFEPLSM-NLREVLKKYGKDVG 131 Query: 158 FTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSH 217 + + + A++ L NI H D+KP+N+L + ILKL DFG A + Sbjct: 132 LHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESK--TILKLCDFGSASHV-AD 188 Query: 218 NSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYS---NHGLAISPG 274 N +T + +Y APE++ + YD DMWS+G +Y L G F NH L ++ Sbjct: 189 NDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMD 248 Query: 275 MK-----TRIRMGQY---------EFPNPEWSEVSE------------------------ 296 +K IR G + F E +V+E Sbjct: 249 LKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQ 308 Query: 297 -----------EVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 ++K L+ +L +P +R++I + + H +I + Sbjct: 309 RLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE 350 >4NEU-A nrPDB Length = 333 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 60/311 (19%), Positives = 115/311 (36%), Gaps = 39/311 (12%) Query: 72 LGINGKVLQIFNKRTQEKFALKMLQDCP------KARREVELHWRASQCPHIVRIVDVYE 125 G GKV F++ TQ +K + P +A E + +V+++ V Sbjct: 34 SGGFGKVSLCFHR-TQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVI- 91 Query: 126 NLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHR 185 +VME ++ G L ++ + + I+ I E + YLH + H+ Sbjct: 92 ---IEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVK--GRIILEIIEGMCYLHGKGVIHK 146 Query: 186 DVKPENLLYTSKRPNAILKLTDFGFAKET--------------TSHNSLTTPCYTPYYVA 231 D+KPEN+L + + +K+ D G A + T YY+A Sbjct: 147 DLKPENILVDN---DFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMA 203 Query: 232 PEVLGP--EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNP 289 PE L K + D++S V+++ + P+ + I+ G + Sbjct: 204 PEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPY---ENAICEQQLIMCIKSGNRPDVDD 260 Query: 290 EWSEVSEEVKMLIRNLLKTEPTQRMTITEFMN--HPWIMQSTKVPQTPLHTSRVLKEDKE 347 E+ L++ + P R T P+ + +++ ++ + LK++ Sbjct: 261 ITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYL--SQLEESVEEDVKSLKKEYS 318 Query: 348 RWEDVKEEMTS 358 V + M S Sbjct: 319 NENAVVKRMQS 329 >4G3E-A nrPDB Length = 352 Score = 175 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 71/317 (22%), Positives = 115/317 (36%), Gaps = 42/317 (13%) Query: 44 PQFHVKSGLQIKKNAIIDDYKVTSQV--------LGLGINGKVLQIFNKRTQEKFALKML 95 P+ G+ + + DY+ +V +G G G+V ++ +K+T + A+K + Sbjct: 48 PETEDNEGVLLTEKLKPVDYEYREEVHWMTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKV 107 Query: 96 QDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGD 155 + R E + P IV + + I ME L+GG L I+ G Sbjct: 108 R-LEVFRVEELVACAGLSSPRIVPLYGAVRE----GPWVNIFMELLEGGSLGQLIKQMG- 161 Query: 156 QAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT 215 E A + E ++YLH+ I H DVK +N+L +S A L DFG A Sbjct: 162 -CLPEDRALYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAA--LCDFGHALCLQ 218 Query: 216 SHNSLTTPC------YTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL 269 + T ++APEV+ + D D+WS +M +L G P+ Sbjct: 219 PDGLGKSLLTGDYIPGTETHMAPEVVMGKPCDAKVDIWSSCCMMLHMLNGCHPW-----T 273 Query: 270 AISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEF---------- 319 G + + I+ L+ EP R + E Sbjct: 274 QYFRGPLCLKIASEPPPIREIPPSCAPLTAQAIQEGLRKEPVHRASAMELRRKVGKALQE 333 Query: 320 ---MNHPWIMQSTKVPQ 333 + PW K P+ Sbjct: 334 VGGLKSPW-KGEYKEPR 349 >6CTH-A nrPDB Length = 309 Score = 174 bits (442), Expect = 6e-44, Method: Composition-based stats. Identities = 64/274 (23%), Positives = 110/274 (40%), Gaps = 33/274 (12%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQDC-----PKARREVELHWRASQCPHIVRIVDVY 124 LG G G V + F + + A+K + + EV++ R + ++V+++ Sbjct: 23 LGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYASEVKIISRL-RHKNLVKLIGWC 81 Query: 125 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN--- 181 R L++V E + G L S I +G T I+K + A+ YLH Sbjct: 82 HE----RGELMLVYEFMANGSLDSHIF-KGKSLLTWEVRYRIVKDLASALLYLHEEGDHC 136 Query: 182 IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTP--CYTPYYVAPEVLGPEK 239 + HRD+K N++ S KL DFG A+ L T Y+APE L K Sbjct: 137 VLHRDIKTSNIMLDSSFN---AKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLSSGK 193 Query: 240 YDKSCDMWSLGVIMYILLCG----YPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV- 294 K D++S GV+ + G P F + L + P + G + ++ Sbjct: 194 ASKESDVYSFGVVALEIASGRRSIEPKFEESEALLLVPWVWES--YGNERILDIADRKLG 251 Query: 295 ----SEEVKML-IRNLLKTEPTQ--RMTITEFMN 321 ++++ L + L P+ R +I + + Sbjct: 252 MAFDPKQLECLVMVGLWCAHPSHNLRPSIRQVIQ 285 >4YFF-A nrPDB Length = 311 Score = 173 bits (440), Expect = 8e-44, Method: Composition-based stats. Identities = 57/307 (18%), Positives = 122/307 (39%), Gaps = 30/307 (9%) Query: 27 ALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRT 86 ++P P + ++ +++GL + + + + +++G G GKV + + Sbjct: 8 SVPSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIE-FHEIIGSGSFGKVYKGRCR-- 64 Query: 87 QEKFALKMLQ--------DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVM 138 + A+K + D REV + + P +++ V N IV Sbjct: 65 NKIVAIKRYRANTYCSKSDVDMFCREVSILCQL-NHPCVIQFVGACLN---DPSQFAIVT 120 Query: 139 ECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH--SINIAHRDVKPENLLYTS 196 + + GG LFS + ++ + + I + + ++YLH + I HRD+ N+L Sbjct: 121 QYISGGSLFSLLHEQK-RILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILL-- 177 Query: 197 KRPNAILKLTDFGFAK--ETTSHNSLTTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIM 253 + + DFG ++ ++ +++T ++APEV +Y D++S + + Sbjct: 178 -YEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCL 236 Query: 254 YILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQR 313 + +L G PF A + M + P + + + L+ P R Sbjct: 237 WEILTGEIPFAHLKPAAAAADM------AYHHIRPPIGYSIPKPISSLLIRGWNACPEGR 290 Query: 314 MTITEFM 320 +E + Sbjct: 291 PEFSEVV 297 >4LFI-A nrPDB Length = 374 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 73/358 (20%), Positives = 129/358 (36%), Gaps = 81/358 (22%) Query: 40 PQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFAL------- 92 Q+ ++ I + DY++ ++V G G +V Q ++ K + Sbjct: 19 KQRTEEYWDYENTVIDWSTNTKDYEIENKV-GRGKYSEVFQGVKLDSKVKIVIKMLKPVK 77 Query: 93 -----------------KM------LQDCPKARREVELHWR----------ASQCPHIVR 119 K+ Q + E + + +I+ Sbjct: 78 KKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIH 137 Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 + D+ ++ + L V E +D + F + + T+ E M + +A+ Y HS Sbjct: 138 LFDIIKDPISKTPAL--VFEYVDNVD-FRILYPK----LTDLEIRFYMFELLKALDYCHS 190 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GPE 238 + I HRDVKP N++ K N L+L D+G A+ + + ++ PE+L Sbjct: 191 MGIMHRDVKPHNVMIDHK--NKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYR 248 Query: 239 KYDKSCDMWSLGVIMYILLCGYPPFYSNHG----------------------------LA 270 YD S D+WS G ++ ++ PF+ Sbjct: 249 MYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPR 308 Query: 271 ISPGMKTRIRMGQYEFPNPEWSEVS--EEVKMLIRNLLKTEPTQRMTITEFMNHPWIM 326 M IR + F N +S +E+ LI NLL+ + +R+T E M HPW Sbjct: 309 EFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 366 >5UIU-A nrPDB Length = 323 Score = 172 bits (435), Expect = 3e-43, Method: Composition-based stats. Identities = 56/303 (18%), Positives = 114/303 (37%), Gaps = 38/303 (12%) Query: 44 PQFHVKSGLQIKKNAIIDDYK-----VTSQVLGLGINGKVLQIFNKRTQEKFALKML--- 95 +FH S ++K + +++ V +G G G V + + T A+K L Sbjct: 26 TRFHSFSFYELKN--VTNNFDERPISVGGNKMGEGGFGVVYKGYVNNT--TVAVKKLAAM 81 Query: 96 ------QDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSR 149 + + +E+++ + Q ++V ++ + L +V + G L R Sbjct: 82 VDITTEELKQQFDQEIKVMAKC-QHENLVELLGF----SSDGDDLCLVYVYMPNGSLLDR 136 Query: 150 I-QDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDF 208 + G + +I + I +LH + HRD+K N+L K++DF Sbjct: 137 LSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAF---TAKISDF 193 Query: 209 GFAK---ETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYS 265 G A+ + + T Y+APE L E D++S GV++ ++ G P Sbjct: 194 GLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI-TPKSDIYSFGVVLLEIITGLPAVDE 252 Query: 266 NHGLAISPGMKTRIRMGQYEFPNPEWSEVS-------EEVKMLIRNLLKTEPTQRMTITE 318 + + +K I + + +++ E + + L + +R I + Sbjct: 253 HREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKK 312 Query: 319 FMN 321 Sbjct: 313 VQQ 315 >3ZZW-A nrPDB Length = 289 Score = 170 bits (431), Expect = 9e-43, Method: Composition-based stats. Identities = 53/281 (18%), Positives = 105/281 (37%), Gaps = 44/281 (15%) Query: 68 QVLGLGINGKVLQIF------NKRTQEKFALKMLQDCPK--ARREV--ELHWRA-SQCPH 116 + LG GKV + ++T + A+K L+D + R E E RA Q P+ Sbjct: 15 EELGEDRFGKVYKGHLFGPAPGEQT-QAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPN 73 Query: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQA--------------FTERE 162 +V ++ V + L ++ G+L + R + + Sbjct: 74 VVCLLGVV----TKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPD 129 Query: 163 ASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT- 221 ++ I ++YL S ++ H+D+ N+L K +K++D G +E + + Sbjct: 130 FVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLN---VKISDLGLFREVYAADYYKL 186 Query: 222 --TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYI-LLCGYPPFYSNHGLAISPGMKTR 278 ++APE + K+ D+WS GV+++ G P+ + ++ R Sbjct: 187 LGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNR 246 Query: 279 IRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEF 319 + P + V L+ P++R + Sbjct: 247 QVL-------PCPDDCPAWVYALMIECWNEFPSRRPRFKDI 280 >3LMG-A nrPDB Length = 344 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 56/279 (20%), Positives = 108/279 (38%), Gaps = 30/279 (10%) Query: 68 QVLGLGINGKVLQIFNKRTQE----KFALKMLQDCP-----KARREVELHWRASQCPHIV 118 +VLG G+ G V + E +K+++D +A + L + HIV Sbjct: 37 KVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIV 96 Query: 119 RIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH 178 R++ + L +V + L G L ++ A + I + + YL Sbjct: 97 RLLGLC-----PGSSLQLVTQYLPLGSLLDHVRQHRG-ALGPQLLLNWGVQIAKGMYYLE 150 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--LTTPCYTP-YYVAPEVL 235 + HR++ N+L S +++ DFG A + L + TP ++A E + Sbjct: 151 EHGMVHRNLAARNVLLKSPSQ---VQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESI 207 Query: 236 GPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 294 KY D+WS GV ++ L+ G P+ + ++ R+ Q + Sbjct: 208 HFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQI-------C 260 Query: 295 SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ 333 + +V M++ + R T E + + + + P+ Sbjct: 261 TIDVYMVMVKCWMIDENIRPTFKE-LANEFTRMARDPPR 298 >2PMN-X nrPDB Length = 348 Score = 168 bits (427), Expect = 3e-42, Method: Composition-based stats. Identities = 62/314 (19%), Positives = 117/314 (37%), Gaps = 51/314 (16%) Query: 56 KNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC---------PKARREVE 106 K+ I+DY++ + L G K++ + + +ALK + ++ Sbjct: 26 KDKYINDYRII-RTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDKIS 82 Query: 107 LHWRASQCPHIVRIVD--------VYENLYAGRKCLLIVMECLDGGELFSR------IQD 152 + + + ++I+ E + + I+ E ++ + + Sbjct: 83 IKSKYDDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDK 142 Query: 153 RGDQAFTEREASEIMKSIGEAIQYLH-SINIAHRDVKPENLLYTSKRPNAILKLTDFGFA 211 + I+KS+ + Y+H NI HRDVKP N+L N +KL+DFG + Sbjct: 143 NYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMD---KNGRVKLSDFGES 199 Query: 212 KETTSHNSLTTPCYTPYYVAPEVLGPEK-Y-DKSCDMWSLGVIMYILLCGYPPFYSNHGL 269 E + T ++ PE E Y D+WSLG+ +Y++ PF L Sbjct: 200 -EYMVDKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISL 258 Query: 270 AISPGMKTRIRMGQYEFPNPEWSEV---------------SEEVKMLIRNLLKTEPTQRM 314 + IR E+P + S E ++ L+ P +R+ Sbjct: 259 V---ELFNNIRTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERI 315 Query: 315 TITEFMNHPWIMQS 328 T + + H W+ + Sbjct: 316 TSEDALKHEWLADT 329 >5LPZ-A nrPDB Length = 332 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 59/274 (21%), Positives = 108/274 (39%), Gaps = 31/274 (11%) Query: 69 VLGLGINGKVLQIFNKRTQEKFALKMLQDCP-KARREVELHWR---ASQCPHIVRIVDVY 124 ++G G G V + K A+K L + RE + ++V ++ Sbjct: 24 LIGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPLLGYC 82 Query: 125 ENLYAGRKCLLIVMECLDGGELFSRIQD--RGDQAFTEREASEIMKSIGEAIQYLHSI-- 180 + G + L +V E + G L + D + +I + +LH Sbjct: 83 K---VGDERL-LVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCS 138 Query: 181 -NIAHRDVKPENLLYTSKRPNAILKLTDFGFAK---ETTSHNSLTTPCYTPYYVAPEVLG 236 +I HRD+K N+L N +++DFG A+ +H S++T TP YV PE Sbjct: 139 PHIIHRDMKSSNVLLDE---NLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQ 195 Query: 237 PEKYDKSCDMWSLGVIMYILLCGYPPF----YSNHGLAISPGMKTRIRMGQYEFPNPEWS 292 + D++S GV++ LL G P + ++ L ++R+ P Sbjct: 196 SFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPELMKE 255 Query: 293 EVSEEVKMLIRN------LLKTEPTQRMTITEFM 320 + + E+ L+++ L +R T+ + M Sbjct: 256 DPALEI-ELLQHLKVAVACLDDRAWRRPTMVQVM 288 >5LPV-A nrPDB Length = 296 Score = 165 bits (419), Expect = 3e-41, Method: Composition-based stats. Identities = 59/274 (21%), Positives = 108/274 (39%), Gaps = 31/274 (11%) Query: 69 VLGLGINGKVLQIFNKRTQEKFALKMLQDCP-KARREVELHWR---ASQCPHIVRIVDVY 124 ++G G G V + K A+K L + RE + ++V ++ Sbjct: 24 LIGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPLLGYC 82 Query: 125 ENLYAGRKCLLIVMECLDGGELFSRIQD--RGDQAFTEREASEIMKSIGEAIQYLHSI-- 180 + G + L +V E + G L + D + +I + +LH Sbjct: 83 K---VGDERL-LVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCS 138 Query: 181 -NIAHRDVKPENLLYTSKRPNAILKLTDFGFAK---ETTSHNSLTTPCYTPYYVAPEVLG 236 +I HRD+K N+L N +++DFG A+ +H S++T TP YV PE Sbjct: 139 PHIIHRDMKSSNVLLDE---NLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQ 195 Query: 237 PEKYDKSCDMWSLGVIMYILLCGYPPF----YSNHGLAISPGMKTRIRMGQYEFPNPEWS 292 + D++S GV++ LL G P + ++ L ++R+ P Sbjct: 196 SFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPELMKE 255 Query: 293 EVSEEVKMLIRN------LLKTEPTQRMTITEFM 320 + + E+ L+++ L +R T+ + M Sbjct: 256 DPALEI-ELLQHLKVAVACLDDRAWRRPTMVQVM 288 >5L2Q-C nrPDB Length = 320 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 63/283 (22%), Positives = 113/283 (39%), Gaps = 48/283 (16%) Query: 79 LQIFNKRTQEKFALKMLQDCPK----------------ARREVELHWRASQCPHIVRIVD 122 T + + LK+L + E L +V Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 123 VYEN--------------LYAGRKCLLIVMECLDGGELFSRIQDR--------GDQAFTE 160 ++++ + +K + +V++CL + + D ++ +E Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 161 REASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET-TSHNS 219 RE I + ++ LH NI HRD+K N++ + + +T+F K + + Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLN--KRTHRITITNFCLGKHLVSEGDL 210 Query: 220 LTTPCYTPYYVAPEVLGPEKY-DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTR 278 L +P Y++P+VL Y K DMW+LGV+++ +L G PFY +I + + Sbjct: 211 LKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYD----SIPQELFRK 266 Query: 279 IRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMN 321 I+ +Y P E VSE LIR LL +P QR+ + + Sbjct: 267 IKAAEYTIP--EDGRVSENTVCLIRKLLVLDPQQRLAAADVLE 307 >5VDK-A nrPDB Length = 297 Score = 165 bits (417), Expect = 4e-41, Method: Composition-based stats. Identities = 64/302 (21%), Positives = 119/302 (39%), Gaps = 50/302 (16%) Query: 51 GLQIKKNAIIDDYK---VTSQVLGLGINGKVLQIFNKRTQEKFALKM-------LQDCPK 100 G + + Y+ + + +G+G G V + + +A+K L + Sbjct: 1 GPEFGSTNMASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENS 60 Query: 101 ARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQD--RGDQAF 158 A EV H PH+VR Y + +A ++I E +GG L + I + + F Sbjct: 61 ALHEVYAHAVLGHHPHVVR----YYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHF 116 Query: 159 TEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSK--------------------R 198 E + +I+ I + Y+H+ ++ H D+KP N+ K Sbjct: 117 EEPKLKDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLS 176 Query: 199 PNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPE-KYDKSCDMWSLGVIMYILL 257 N + K+ D G A TS N ++A E+L + ++ D+++LG+ + + Sbjct: 177 ANVMYKIGDLGHA---TSINKPKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAA 233 Query: 258 CGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTIT 317 L + IR G FP+ E+SE L++N+++ + QR + Sbjct: 234 -------GAESLPTNGAAWHHIRKG--NFPDVP-QELSESFSSLLKNMIQPDAEQRPSAA 283 Query: 318 EF 319 Sbjct: 284 AL 285 >5WNL-A nrPDB Length = 342 Score = 164 bits (416), Expect = 5e-41, Method: Composition-based stats. Identities = 47/262 (17%), Positives = 102/262 (38%), Gaps = 18/262 (6%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENL 127 + +G G G+V ++ + + A+K RE ++ + + + Sbjct: 26 EKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVY 85 Query: 128 YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN--IAHR 185 ++ + +VME ++ G L + + I+ + +LH ++ + H Sbjct: 86 GICQEPVGLVMEYMETGSLEKLLAS---EPLPWDLRFRIVHETAVGMNFLHCMSPPLLHL 142 Query: 186 DVKPENLLYTSKRPNAILKLTDFGFAK----ETTSHNSLTTPCYTPYYVAPEVLGPEK-- 239 ++KP N+L + + +K++DFG AK + S+ T Y+ PE + + Sbjct: 143 NLKPANILLDA---HYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKSRL 199 Query: 240 YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN--PEWSEVSEE 297 +D D++S ++++ +L PF I M ++ + E P Sbjct: 200 FDTKHDVYSFAIVIWGVLTQKKPFADEKN--ILHIMMKVVKGHRPELPPICRPRPRACAS 257 Query: 298 VKMLIRNLLKTEPTQRMTITEF 319 + L++ +P R T E Sbjct: 258 LIGLMQRCWHADPQVRPTFQEI 279 >5TOS-A nrPDB Length = 395 Score = 164 bits (416), Expect = 6e-41, Method: Composition-based stats. Identities = 55/284 (19%), Positives = 105/284 (36%), Gaps = 39/284 (13%) Query: 69 VLGLGINGKVLQI---------FNKRTQEKFALKMLQDC-----PKARREVELHWRASQC 114 V+G G G V + T A+K L + E+ + S Sbjct: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLS-H 130 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRG--DQAFTEREASEIMKSIGE 172 P++V+++ + L+V E + G L + + RG + + + Sbjct: 131 PNLVKLIGYC----LEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAK 186 Query: 173 AIQYLHS--INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN---SLTTPCYTP 227 + +LHS + + +RD+K N+L + + KL+DFG A++ + T T Sbjct: 187 GLAFLHSDPVKVIYRDIKASNILLDA---DYNAKLSDFGLARDGPMGDLSYVSTRVMGTY 243 Query: 228 YYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLA-------ISPGMKTRIR 280 Y APE + + D++S GV++ +L G N P + ++ + Sbjct: 244 GYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRK 303 Query: 281 MGQYEFPNPEWSEVSEEVKMLIR---NLLKTEPTQRMTITEFMN 321 + + + EE + L EP R T+ + + Sbjct: 304 VLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 >2Y4I-B nrPDB Length = 319 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 60/306 (19%), Positives = 128/306 (41%), Gaps = 43/306 (14%) Query: 39 PPQQFPQFHVKSGLQIKK-NAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ- 96 + FP+ ++ + +++ + + ++ +++G G G+V + R + A++++ Sbjct: 10 SARSFPRKASQTSIFLQEWDIPFEQLEI-GELIGKGRFGQVY---HGRWHGEVAIRLIDI 65 Query: 97 ------DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRI 150 +REV + +R ++ ++V ++ L I+ G L+S + Sbjct: 66 ERDNEDQLKAFKREV-MAYRQTRHENVV----LFMGACMSPPHLAIITSLCKGRTLYSVV 120 Query: 151 QDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGF 210 +D + +I + I + + YLH+ I H+D+K +N+ Y N + +TDFG Sbjct: 121 RD-AKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYD----NGKVVITDFGL 175 Query: 211 ------AKETTSHNSLTTPCYTPYYVAPEVLG---------PEKYDKSCDMWSLGVIMYI 255 + + L ++APE++ + K D+++LG I Y Sbjct: 176 FSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYE 235 Query: 256 LLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMT 315 L PF + AI M T ++ PN + +E+ ++ E +R T Sbjct: 236 LHAREWPFKTQPAEAIIWQMGTGMK------PNLSQIGMGKEISDILLFCWAFEQEERPT 289 Query: 316 ITEFMN 321 T+ M+ Sbjct: 290 FTKLMD 295 >6J5U-C nrPDB Length = 426 Score = 161 bits (407), Expect = 5e-40, Method: Composition-based stats. Identities = 62/289 (21%), Positives = 109/289 (37%), Gaps = 53/289 (18%) Query: 69 VLGLGINGKVLQIFNKRT---------QEKFALKMLQ-----DCPKARREVELHWRASQC 114 +LG G G V + + +T A+K L+ + EV + S Sbjct: 91 LLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGHKEWLTEVNYLGQLS-H 149 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 P++V +V G L +V E + G L + + RG Q T ++ + + Sbjct: 150 PNLVLLVGYC---AEGENRL-LVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGAAKGL 205 Query: 175 QYLHSIN--IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL---TTPCYTPYY 229 +LH + +RD K N+L + + KL+DFG AK + ++ T T Y Sbjct: 206 TFLHEAKSQVIYRDFKAANILLDA---DFNAKLSDFGLAKAGPTGDNTHVSTKVIGTHGY 262 Query: 230 VAPEVLGPEKYDKSCDMWSLGVIMYILLCGY------------------PPFYSNHGLAI 271 APE + + D++S GV++ L+ G P+ + + Sbjct: 263 AAPEYVATGRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLVDWATPYLGDK-RKL 321 Query: 272 SPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM 320 M T++ GQY P+ + L L + R ++E + Sbjct: 322 FRIMDTKL-GGQY----PQKGAFT--AANLALQCLNPDAKLRPKMSEVL 363 >4WUA-A nrPDB Length = 401 Score = 160 bits (405), Expect = 9e-40, Method: Composition-based stats. Identities = 67/379 (17%), Positives = 119/379 (31%), Gaps = 101/379 (26%) Query: 45 QFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC----PK 100 + +K + + + LG G V ++ + ++ A+K+++ Sbjct: 24 DYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTET 83 Query: 101 ARREVELHWRASQC-PH------IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDR 153 A E+ L P+ +V+++D ++ + +V E L G L I Sbjct: 84 ALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVL-GHHLLKWIIKS 142 Query: 154 GDQAFTEREASEIMKSIGEAIQYLHSI-NIAHRDVKPENLLYT----------------- 195 Q +I++ + + + YLH+ I H D+KPEN+L + Sbjct: 143 NYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQ 202 Query: 196 -----------------------------SKRPNAILKLTDFGFAKETTSHNSLTTPCYT 226 +K+ D G A H T T Sbjct: 203 RSGAPPPSGSAVSTAPATAGNFLVNPLEPKNAEKLKVKIADLGNACWV--HKHFTEDIQT 260 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGM----------- 275 Y + EVL Y+ D+WS + + L G F + G + Sbjct: 261 RQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLG 320 Query: 276 ---KTRIRMGQYE---FPNP-------------------EWSEVSEE----VKMLIRNLL 306 + I G+Y F E E S+E + +L Sbjct: 321 KVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPML 380 Query: 307 KTEPTQRMTITEFMNHPWI 325 + P +R T E + HPW+ Sbjct: 381 ELIPEKRATAAECLRHPWL 399 >5VC6-A nrPDB Length = 289 Score = 160 bits (405), Expect = 1e-39, Method: Composition-based stats. Identities = 66/307 (21%), Positives = 125/307 (40%), Gaps = 51/307 (16%) Query: 54 IKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-------DCPKARREVE 106 +K + +++ + +G G G V + + +A+K + D A REV Sbjct: 5 MKSRYTTEFHEL--EKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVY 62 Query: 107 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQD--RGDQAFTEREAS 164 H Q H+VR Y + +A +LI E +GG L I + R F E E Sbjct: 63 AHAVLGQHSHVVR----YFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELK 118 Query: 165 EIMKSIGEAIQYLHSINIAHRDVKPENLLY---------------TSKRPNAIL-KLTDF 208 +++ +G ++Y+HS+++ H D+KP N+ N ++ K+ D Sbjct: 119 DLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDL 178 Query: 209 GFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDK--SCDMWSLGVIMYILLCGYPPFY-- 264 G T +S ++A EVL E Y D+++L + + + G P Sbjct: 179 G---HVTRISSPQVEEGDSRFLANEVLQ-ENYTHLPKADIFALALTV-VCAAGAEPLPRN 233 Query: 265 SNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPW 324 + I G RI P+ +S+E L++ ++ +P +R + + H Sbjct: 234 GDQWHEIRQGRLPRI---------PQV--LSQEFTELLKVMIHPDPERRPSAMALVKHSV 282 Query: 325 IMQSTKV 331 ++ +++ Sbjct: 283 LLSASRK 289 >2X7G-A nrPDB Length = 389 Score = 158 bits (401), Expect = 3e-39, Method: Composition-based stats. Identities = 68/378 (17%), Positives = 122/378 (32%), Gaps = 99/378 (26%) Query: 44 PQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC----P 99 + +K + + + LG G V ++ + + A+K+++ Sbjct: 13 ADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTE 72 Query: 100 KARREVELHW--RASQ--CPH---IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQD 152 A E++L R S P+ +V+++D ++ + +V E L G L I Sbjct: 73 TALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVL-GHHLLKWIIK 131 Query: 153 RGDQAFTEREASEIMKSIGEAIQYLHSI-NIAHRDVKPENLL------------------ 193 Q R I++ + + + YLHS I H D+KPEN+L Sbjct: 132 SNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEW 191 Query: 194 -------------------------YTSKRPNAI-LKLTDFGFAKETTSHNSLTTPCYTP 227 + + I +K+ D G A H T T Sbjct: 192 QKAGAPPPSGSAVSTAPAADLLVNPLDPRNADKIRVKIADLGNACWV--HKHFTEDIQTR 249 Query: 228 YYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFY----------SNHGLAISPGMKT 277 Y + EVL Y D+WS + + L G F +H I + + Sbjct: 250 QYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGS 309 Query: 278 RIR----MGQYEF----PNPEWSEVSE----------------------EVKMLIRNLLK 307 R G+Y E +++ + + +L+ Sbjct: 310 IPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLE 369 Query: 308 TEPTQRMTITEFMNHPWI 325 P +R + E + HPW+ Sbjct: 370 MVPEKRASAGECLRHPWL 387 >3VHK-A nrPDB Length = 368 Score = 157 bits (398), Expect = 6e-39, Method: Composition-based stats. Identities = 38/169 (22%), Positives = 73/169 (43%), Gaps = 13/169 (7%) Query: 158 FTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSH 217 T + + +++L S HRD+ N+L + K ++K+ DFG A++ Sbjct: 197 LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKN---VVKICDFGLARDIYKD 253 Query: 218 NSLTTPCYTP---YYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISP 273 ++APE + Y D+WS GV+++ + G P+ G+ I Sbjct: 254 PDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPY---PGVKIDE 310 Query: 274 GMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNH 322 R++ G P+++ + E+ + + EP+QR T +E + H Sbjct: 311 EFCRRLKEGT-RMRAPDYT--TPEMYQTMLDCWHGEPSQRPTFSELVEH 356 Score = 77.3 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 28/184 (15%), Positives = 60/184 (32%), Gaps = 39/184 (21%) Query: 16 APAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGIN 75 A P P H P +FP+ +K + LG G Sbjct: 2 AMDPDELPLD---EHCERLPYDASKWEFPRDRLK----------------LGKPLGRGAF 42 Query: 76 GKVLQI----FNK-RTQEKFALKMLQDCPK------ARREVELHWRASQCPHIVRIVDVY 124 G+V++ +K T A+KML++ E+++ ++V ++ Sbjct: 43 GQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGAC 102 Query: 125 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 184 L++++E G L + ++ + ++ + + Y+ Sbjct: 103 ---TKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQ---GKDYV---GAIP 153 Query: 185 RDVK 188 D+K Sbjct: 154 VDLK 157 >3UIM-A nrPDB Length = 326 Score = 157 bits (398), Expect = 7e-39, Method: Composition-based stats. Identities = 58/310 (18%), Positives = 114/310 (36%), Gaps = 31/310 (10%) Query: 35 PPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM 94 P +++ + D +LG G GKV + A+K Sbjct: 3 DVPAEEDPEVHLGQLKRFSLRELQVASDNFSNKNILGRGGFGKVYKGR-LADGTLVAVKR 61 Query: 95 LQDCPKARREVELHWRASQ-----CPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSR 149 L++ E++ +++R+ L+V + G + S Sbjct: 62 LKEERTQGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTER----LLVYPYMANGSVASC 117 Query: 150 IQDRGD--QAFTEREASEIMKSIGEAIQYLHSI---NIAHRDVKPENLLYTSKRPNAILK 204 +++R + + I + YLH I HRDVK N+L + Sbjct: 118 LRERPESQPPLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAV--- 174 Query: 205 LTDFGFAKETTSHNSLTTPC--YTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPP 262 + DFG AK ++ T T ++APE L K + D++ GV++ L+ G Sbjct: 175 VGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQRA 234 Query: 263 FY-----SNHGLAISPGMKTRIRMGQYE---FPNPEWSEVSEEVKMLIR---NLLKTEPT 311 F ++ + + +K ++ + E + + + EEV+ LI+ ++ P Sbjct: 235 FDLARLANDDDVMLLDWVKGLLKEKKLEALVDVDLQGNYKDEEVEQLIQVALLCTQSSPM 294 Query: 312 QRMTITEFMN 321 +R ++E + Sbjct: 295 ERPKMSEVVR 304 >3REP-A nrPDB Length = 271 Score = 155 bits (392), Expect = 3e-38, Method: Composition-based stats. Identities = 45/248 (18%), Positives = 98/248 (39%), Gaps = 28/248 (11%) Query: 77 KVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLI 136 KVL++ + T++ + E R P+++ ++ ++ A L Sbjct: 39 KVLKVRDWSTRK----------SRDFNEECPRLRIFSHPNVLPVLGACQSPPAPHPTL-- 86 Query: 137 VMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN-IAHRDVKPENLLYT 195 + + G L++ + + + + +A + + + +LH++ + R + Sbjct: 87 ITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVMI 146 Query: 196 SKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYD---KSCDMWSLGVI 252 + A + + D F+ ++ Y P +VAPE L + D +S DMWS V+ Sbjct: 147 DEDMTARISMADVKFSFQSP------GRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVL 200 Query: 253 MYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQ 312 ++ L+ PF + I GMK + + P +S V L++ + +P + Sbjct: 201 LWELVTREVPFADLSNMEI--GMKVALEGLRPTIP----PGISPHVSKLMKICMNEDPAK 254 Query: 313 RMTITEFM 320 R + Sbjct: 255 RPKFDMIV 262 >3Q4U-A nrPDB Length = 301 Score = 154 bits (389), Expect = 7e-38, Method: Composition-based stats. Identities = 61/289 (21%), Positives = 106/289 (36%), Gaps = 46/289 (15%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWR-ASQCPHIVRIVDVYEN 126 +G G G+V + + E A+K+ +D RE EL+ + +I+ + Sbjct: 16 VGKGRYGEVWRGSWQ--GENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMT 73 Query: 127 LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH-------- 178 L ++ + G L+ +Q + I+ SI + +LH Sbjct: 74 SRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVS---CLRIVLSIASGLAHLHIEIFGTQG 130 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK-ETTSHNSLTT----PCYTPYYVAPE 233 IAHRD+K +N+L + N + D G A + S N L T Y+APE Sbjct: 131 KPAIAHRDLKSKNILV---KKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPE 187 Query: 234 VLGP-------EKYDKSCDMWSLGVIMYILLCG----------YPPFYSNHGLAISPGMK 276 VL + Y K D+W+ G++++ + PPFY S Sbjct: 188 VLDETIQVDCFDSY-KRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDM 246 Query: 277 TRIRMGQYEFPNPEWSEVSE----EVKMLIRNLLKTEPTQRMTITEFMN 321 ++ + PN S+ + L++ P+ R+T Sbjct: 247 RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKK 295 >2QKW-B nrPDB Length = 321 Score = 153 bits (388), Expect = 9e-38, Method: Composition-based stats. Identities = 55/270 (20%), Positives = 104/270 (38%), Gaps = 26/270 (9%) Query: 69 VLGLGINGKVLQIFNKRTQEKFALKM----LQDCPKARREVELHWRASQCPHIVRIVDVY 124 ++G G+ GKV + + K ALK + + PH+V ++ Sbjct: 46 LIGHGVFGKVYKGVLRD-GAKVALKRRTPESSQGIEEFETEIETLSFCRHPHLVSLIGFC 104 Query: 125 ENLYAGRKCLLIVMECLDGGELFSRI--QDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182 + R ++++ + ++ G L + D + + + EI + YLH+ I Sbjct: 105 DE----RNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTRAI 160 Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL---TTPCYTPYYVAPEVLGPEK 239 HRDVK N+L N + K+TDFG +K+ T + T T Y+ PE + Sbjct: 161 IHRDVKSINILLDE---NFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKGR 217 Query: 240 YDKSCDMWSLGVIMYILLCGYP------PFYSNHGLAISPGMKTRIRMGQYEFPNPEWSE 293 + D++S GV+++ +LC P + + ++ Q PN Sbjct: 218 LTEKSDVYSFGVVLFEVLCARSAIVQSLPREMVNLAEWAVESHNNGQLEQIVDPNLADKI 277 Query: 294 VSEEVKMLIR---NLLKTEPTQRMTITEFM 320 E ++ L R ++ + + Sbjct: 278 RPESLRKFGDTAVKCLALSSEDRPSMGDVL 307 >2H34-A nrPDB Length = 309 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 63/260 (24%), Positives = 105/260 (40%), Gaps = 25/260 (9%) Query: 64 KVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD--------CPKARREVELHWRASQCP 115 +++G G G V + + + ALK++ + + +RE R Q P Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRL-QEP 94 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 H+V I D E L + M ++G +L + ++ +G A I++ IG A+ Sbjct: 95 HVVPIHDFGE----IDGQLYVDMRLINGVDLAAMLRRQG--PLAPPRAVAIVRQIGSALD 148 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSH--NSLTTPCYTPYYVAPE 233 H+ HRDVKPEN+L ++ + L DFG A TT L T YY+APE Sbjct: 149 AAHAAGATHRDVKPENILVSA---DDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPE 205 Query: 234 VLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSE 293 D+++L ++Y L G PP+ + + + I P+ Sbjct: 206 RFSESHATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPR-----PSTVRPG 260 Query: 294 VSEEVKMLIRNLLKTEPTQR 313 + +I + P R Sbjct: 261 IPVAFDAVIARGMAKNPEDR 280 >3QD2-B nrPDB Length = 332 Score = 152 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 64/333 (19%), Positives = 115/333 (34%), Gaps = 87/333 (26%) Query: 62 DYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQD------CPKARREVELHWRASQCP 115 D++ Q +G G G V + NK +A+K ++ K REV+ + P Sbjct: 7 DFEPI-QCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLE-HP 64 Query: 116 HI---------------------------------------------VRIVDVYENL--- 127 I +R +D + Sbjct: 65 GIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTV 124 Query: 128 -----YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREA-SEIMKSIGEAIQYLHSIN 181 + + L I M+ L + R E I I EA+++LHS Sbjct: 125 GQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKG 184 Query: 182 IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS-------------LTTPCYTPY 228 + HRD+KP N+ +T + ++K+ DFG T T Sbjct: 185 LMHRDLKPSNIFFT---MDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKL 241 Query: 229 YVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN 288 Y++PE + Y D++SLG+I++ LL + ++ + +FP Sbjct: 242 YMSPEQIHGNNYSHKVDIFSLGLILFELLYSFS--------TQMERVRIITDVRNLKFPL 293 Query: 289 PEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMN 321 + +E M+++++L PT+R T+ + Sbjct: 294 LFTQKYPQE-HMMVQDMLSPSPTERPEATDIIE 325 >5AR8-A nrPDB Length = 326 Score = 151 bits (382), Expect = 5e-37, Method: Composition-based stats. Identities = 55/274 (20%), Positives = 105/274 (38%), Gaps = 29/274 (10%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKML--------QDCPKARREVELHWRASQCPHIVR 119 + L G +G V + + + A+K L + RE E+ +A + +I+ Sbjct: 38 RYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKA-RFSYILP 96 Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQA-FTEREASEIMKSIGEAIQYLH 178 I+ + + L IV E + G L + + + I+ I + YLH Sbjct: 97 ILGICNE----PEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLH 152 Query: 179 SIN--IAHRDVKPENLLYTSKRPNAILKLTDFGFAK------ETTSHNSLTTPCYTPYYV 230 ++ + H D+K +N+L ++ +K+ DFG +K + + T Y+ Sbjct: 153 NMTPPLLHHDLKTQNILLDNEF---HVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYM 209 Query: 231 APEVLGPEKYDKSC---DMWSLGVIMYILLCGYPPFYS-NHGLAISPGMKTRIRMGQYEF 286 PE P + ++ D++S VI + +L PF + L I + R E Sbjct: 210 PPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEE 269 Query: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM 320 P + LI + P +R + + + Sbjct: 270 SLPYDIPHRARMISLIESGWAQNPDERPSFLKCL 303 >2WTK-B nrPDB Length = 373 Score = 150 bits (380), Expect = 8e-37, Method: Composition-based stats. Identities = 55/320 (17%), Positives = 102/320 (31%), Gaps = 62/320 (19%) Query: 63 YKVTSQVLGLGING--KVLQIFNKRTQEKFALKMLQDCPKARREV------ELHW-RASQ 113 Y++ + V+G G V K T E ++ + + E+ ELH + Sbjct: 11 YELLT-VIGKGFEDLMTVNLARYKPTGEYVTVRRI-NLEACSNEMVTFLQGELHVSKLFN 68 Query: 114 CPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEA 173 P+IV Y + L +V + G I E + I++ + +A Sbjct: 69 HPNIVP----YRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKA 124 Query: 174 IQYLHSINIAHRDVKPENLLYTSKRP------NAILKLTDFGFAKETTSHNSLTTPCYTP 227 + Y+H + HR VK ++L + + L + G ++ H+ Sbjct: 125 LDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQ-RQRVVHDFPKYSVKVL 183 Query: 228 YYVAPEVLGP--EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTR------- 278 +++PEVL + YD D++S+G+ L G+ PF + Sbjct: 184 PWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLD 243 Query: 279 ---IRMGQYEFPN----------------------------PEWSEVSEEVKMLIRNLLK 307 I + P S + L+ Sbjct: 244 TSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQ 303 Query: 308 TEPTQRMTITEFMNHPWIMQ 327 P R + + +NH + Q Sbjct: 304 RNPDARPSASTLLNHSFFKQ 323 >5XD6-A nrPDB Length = 305 Score = 150 bits (380), Expect = 9e-37, Method: Composition-based stats. Identities = 47/221 (21%), Positives = 84/221 (38%), Gaps = 27/221 (12%) Query: 59 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARRE----VELHWRASQC 114 I D+Y + ++G G G+V K + + A+K L + +E V + R Q Sbjct: 20 ITDNY-GSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQPDQEFLAQVSMVSRLRQ- 76 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGD-------QAFTEREASEIM 167 ++V ++ ++ E G L + R + + +I Sbjct: 77 ENVVALLGYC----VDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIA 132 Query: 168 KSIGEAIQYLHSI---NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL---T 221 ++YLH ++ HRD+K N+L + + K+ DF + + + T Sbjct: 133 VGAARGLEYLHEKANPHVIHRDIKSSNVLLFD---DDVAKIADFDLSNQAPDMAARLHST 189 Query: 222 TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPP 262 T Y APE D++S GV++ LL G P Sbjct: 190 RVLGTFGYHAPEYAMTGTLSTKSDVYSFGVVLLELLTGRKP 230 >4BTK-A nrPDB Length = 337 Score = 150 bits (380), Expect = 9e-37, Method: Composition-based stats. Identities = 55/262 (20%), Positives = 103/262 (39%), Gaps = 25/262 (9%) Query: 56 KNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM---LQDCPKARREVELHWRAS 112 + D +KV + +G G G++ + + T+E ALK+ Q + EV + + Sbjct: 51 NYVVKDRWKVLKK-IGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQ 109 Query: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 H+ R + N K +VM+ G L + + FT + K I E Sbjct: 110 GKDHVCRFIGCGRN----EKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILE 164 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILK--LTDFGFAKETTSHN-------SLTTP 223 +I+ +HS+ HRD+KP N + P+ K + DFG A++ T+ ++ Sbjct: 165 SIEAIHSVGFLHRDIKPSNFAMG-RLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGF 223 Query: 224 CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQ 283 T Y + + + D+WSL ++ G P+ I + + + Sbjct: 224 RGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWR-----KIKDKEQVGMIKEK 278 Query: 284 YEFPNPEWSEVSEEVKMLIRNL 305 YE + E + + ++ Sbjct: 279 YEH-RMLLKHMPSEFHLFLDHI 299 >3MDY-A nrPDB Length = 337 Score = 150 bits (379), Expect = 1e-36, Method: Composition-based stats. Identities = 57/286 (19%), Positives = 104/286 (36%), Gaps = 46/286 (16%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKA--RREVELHWR-ASQCPHIVRIVDVY 124 + +G G G+V K EK A+K+ +A RE E++ + +I+ + Sbjct: 43 KQIGKGRYGEVWMG--KWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAAD 100 Query: 125 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI---- 180 L ++ + + G L+ ++ + ++ S + +LH+ Sbjct: 101 IKGTGSWTQLYLITDYHENGSLYDYLKS---TTLDAKSMLKLAYSSVSGLCHLHTEIFST 157 Query: 181 ----NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS-----LTTPCYTPYYVA 231 IAHRD+K +N+L + N + D G A + S + T T Y+ Sbjct: 158 QGKPAIAHRDLKSKNILV---KKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMP 214 Query: 232 PEVLGP-------EKYDKSCDMWSLGVIMYILLCG----------YPPFYSNHGLAISPG 274 PEVL + Y DM+S G+I++ + P++ S Sbjct: 215 PEVLDESLNRNHFQSY-IMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYE 273 Query: 275 MKTR---IRMGQYEFPNP-EWSEVSEEVKMLIRNLLKTEPTQRMTI 316 I+ + FPN E ++ L+ P R+T Sbjct: 274 DMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTA 319 >4NFN-A nrPDB Length = 309 Score = 149 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 55/262 (20%), Positives = 103/262 (39%), Gaps = 25/262 (9%) Query: 56 KNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM---LQDCPKARREVELHWRAS 112 + D +KV + +G G G++ + + T+E ALK+ Q + EV + + Sbjct: 16 NYVVKDRWKVLKK-IGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQ 74 Query: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 H+ R + N K +VM+ G L + + FT + K I E Sbjct: 75 GKDHVCRFIGCGRN----EKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILE 129 Query: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILK--LTDFGFAKETTSHN-------SLTTP 223 +I+ +HS+ HRD+KP N + P+ K + DFG A++ T+ ++ Sbjct: 130 SIEAIHSVGFLHRDIKPSNFAMG-RLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGF 188 Query: 224 CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQ 283 T Y + + + D+WSL ++ G P+ I + + + Sbjct: 189 RGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWR-----KIKDKEQVGMIKEK 243 Query: 284 YEFPNPEWSEVSEEVKMLIRNL 305 YE + E + + ++ Sbjct: 244 YEH-RMLLKHMPSEFHLFLDHI 264 >4RT7-A nrPDB Length = 415 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 40/221 (18%), Positives = 92/221 (41%), Gaps = 26/221 (11%) Query: 103 REVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTERE 162 REV++ P +I ++ N + + E + L + T + Sbjct: 198 REVQI------HPDSDQISGLHGNSFHSEDEI----EYENQKRLEE---EEDLNVLTFED 244 Query: 163 ASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTT 222 + + +++L + HRD+ N+L T + ++K+ DFG A++ S ++ Sbjct: 245 LLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK---VVKICDFGLARDIMSDSNYVV 301 Query: 223 PCYTP---YYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTR 278 ++APE L Y D+WS G++++ + G P+ G+ + Sbjct: 302 RGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPY---PGIPVDANFYKL 358 Query: 279 IRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEF 319 I+ G ++ P ++ +EE+ +++++ + +R + Sbjct: 359 IQNG-FKMDQPFYA--TEEIYIIMQSCWAFDSRKRPSFPNL 396 Score = 76.5 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 21/128 (16%), Positives = 50/128 (39%), Gaps = 31/128 (24%) Query: 40 PQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFN---KRTQ--EKFALKM 94 +FP+ +++ G +VLG G GKV+ +T + A+KM Sbjct: 59 KWEFPRENLEFG----------------KVLGSGAFGKVMNATAYGISKTGVSIQVAVKM 102 Query: 95 LQDC------PKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFS 148 L++ E+++ + +IV ++ + ++ E G+L + Sbjct: 103 LKEKADSSEREALMSELKMMTQLGSHENIVNLLGAC----TLSGPIYLIFEYCCYGDLLN 158 Query: 149 RIQDRGDQ 156 ++ + ++ Sbjct: 159 YLRSKREK 166 >4M66-A nrPDB Length = 325 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 60/307 (19%), Positives = 121/307 (39%), Gaps = 32/307 (10%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENL 127 + +G G G V + ++ A+K++ + K EV+ + +++ ++ V E+L Sbjct: 26 EFVGKGGFGVVFRAHHRTWNHDVAVKIV-NSKKISWEVKAMVNL-RNENVLLLLGVTEDL 83 Query: 128 YAGRKC-LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN--IAH 184 +V ++ G L +Q + +++ + + YLHS++ + H Sbjct: 84 QWDFVSGQALVTRFMENGSLAGLLQPEAPR--PWPLLCRLLQEVVLGMCYLHSLDPPLLH 141 Query: 185 RDVKPENLLYTSKRPNAILKLTDFGFAK-------ETTSHNSLTTPCYTPYYVAPEVLGP 237 RD+KP N+L P KL DFG + + S + T Y+ PE+L Sbjct: 142 RDLKPSNILLD---PELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDPELLFK 198 Query: 238 --EKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS 295 K K+ D++S G++++ +L G + I + R P E Sbjct: 199 VNLKASKASDVYSFGILVWAVLAGREAELVDKTSLIRETVCDRQSRPPLTELPPGSPETP 258 Query: 296 --EEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVK 353 E++K L+ + ++ R + + P+T + V + +VK Sbjct: 259 GLEKLKELMIHCWGSQSENRPSFQDC-----------EPKTNEVYNLVKDKVDAAVSEVK 307 Query: 354 EEMTSAL 360 ++ L Sbjct: 308 HYLSQHL 314 >3MY0-A nrPDB Length = 305 Score = 148 bits (374), Expect = 4e-36, Method: Composition-based stats. Identities = 57/288 (19%), Positives = 97/288 (33%), Gaps = 44/288 (15%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWR-ASQCPHIVRIVDVYEN 126 +G G G+V + E A+K+ +D RE E++ + +I+ + Sbjct: 16 VGKGRYGEVWRGLWH--GESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMT 73 Query: 127 LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH-------- 178 L ++ + G L+ +Q Q A + S + +LH Sbjct: 74 SRNSSTQLWLITHYHEHGSLYDFLQR---QTLEPHLALRLAVSAACGLAHLHVEIFGTQG 130 Query: 179 SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL-----TTPCYTPYYVAPE 233 IAHRD K N+L + N + D G A + + T Y+APE Sbjct: 131 KPAIAHRDFKSRNVLV---KSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPE 187 Query: 234 VLGPEKYD------KSCDMWSLGVIMYILLCG----------YPPFYS-NHGLAISPGMK 276 VL + K D+W+ G++++ + PPFY MK Sbjct: 188 VLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMK 247 Query: 277 TRIRMGQYEFPNPEWSEVSEEVKML---IRNLLKTEPTQRMTITEFMN 321 + + Q P + L +R P+ R+T Sbjct: 248 KVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKK 295 >1PY5-A nrPDB Length = 326 Score = 145 bits (367), Expect = 3e-35, Method: Composition-based stats. Identities = 55/293 (18%), Positives = 102/293 (34%), Gaps = 44/293 (15%) Query: 65 VTSQVLGLGINGKVLQIFNKRTQEKFALKML--QDCPKARREVELHWR-ASQCPHIVRIV 121 V + +G G G+V + K E+ A+K+ ++ RE E++ + +I+ + Sbjct: 32 VLQESIGKGRFGEVWRG--KWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFI 89 Query: 122 DVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH--- 178 L +V + + G LF + T ++ S + +LH Sbjct: 90 AADNKDNGTWTQLWLVSDYHEHGSLFDYLNR---YTVTVEGMIKLALSTASGLAHLHMEI 146 Query: 179 -----SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL-----TTPCYTPY 228 IAHRD+K +N+L + N + D G A S T Sbjct: 147 VGTQGKPAIAHRDLKSKNILV---KKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKR 203 Query: 229 YVAPEV----LGPEKYD--KSCDMWSLGVIMYILLCG----------YPPFYSNHGLAIS 272 Y+APEV + + ++ K D++++G++ + + P+Y S Sbjct: 204 YMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPS 263 Query: 273 PGMKTRIRMGQYEFPNPEWSEVSEEV----KMLIRNLLKTEPTQRMTITEFMN 321 ++ Q PN S E ++R R+T Sbjct: 264 VEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK 316 >4F9B-A nrPDB Length = 361 Score = 145 bits (367), Expect = 3e-35, Method: Composition-based stats. Identities = 73/355 (20%), Positives = 114/355 (32%), Gaps = 95/355 (26%) Query: 58 AIIDDYKVTSQVLGLGINGKVLQIF---NKRTQEKFALKMLQDCPKARR---EVELHWRA 111 + + +K+ + +G G V +EK ALK L R E++ A Sbjct: 18 QLSNVFKIEDK-IGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVA 76 Query: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 +++ + + ++I M L+ + + +E E M ++ Sbjct: 77 GGQDNVMGVKYCFR----KNDHVVIAMPYLEHESFLDILNS-----LSFQEVREYMLNLF 127 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS--------------- 216 +A++ +H I HRDVKP N LY + L DFG A+ T Sbjct: 128 KALKRIHQFGIVHRDVKPSNFLYNRRLKKYA--LVDFGLAQGTHDTKIELLKFVQSEAQQ 185 Query: 217 --------------HNSLTTPCYTPYYVAPEVLGPEK-YDKSCDMWSLGVIMYILLCGYP 261 + TP + APEVL + DMWS GVI LL G Sbjct: 186 ERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRY 245 Query: 262 PFYSNHGLAISPGMKTRIRMGQYEF----------------PNPE--------------- 290 PFY + IR + P + Sbjct: 246 PFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSST 305 Query: 291 ----------------WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQST 329 W+EV +E L+ LL P R+T E + HP+ + Sbjct: 306 PKLTSDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMS 360 >5E8V-A nrPDB Length = 316 Score = 145 bits (366), Expect = 3e-35, Method: Composition-based stats. Identities = 54/291 (18%), Positives = 105/291 (36%), Gaps = 49/291 (16%) Query: 69 VLGLGINGKVLQIFNKRTQ----EKFALKML--QDCPKARREVELHWRA-SQCPHIVRIV 121 ++G G +V + K+ E A+K+ ++ + E ++ + +I++ + Sbjct: 16 LVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFL 75 Query: 122 DVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS-- 179 E K ++ G L + + + ++ S+ I +LHS Sbjct: 76 TAEERKTELGKQYWLITAFHAKGNLQEYLTRH---VISWEDLRKLGSSLARGIAHLHSDH 132 Query: 180 -------INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL-----TTPCYTP 227 + I HRD+K N+L + + L DFG + S+ + T Sbjct: 133 TPCGRPKMPIVHRDLKSSNILV---KNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA 189 Query: 228 YYVAPEVLGP-------EKYDKSCDMWSLGVIMYILLCG----------YPPFYS---NH 267 Y+APEVL E + K D++S+ ++++ + PPF S H Sbjct: 190 RYMAPEVLASAMNLENVESF-KQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREH 248 Query: 268 GLAISPGMKTRIRMGQYEFPNPEWSEVSEE-VKMLIRNLLKTEPTQRMTIT 317 S G+ E P+ + + V + +P R+T Sbjct: 249 PCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQ 299 >3G2F-A nrPDB Length = 336 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 61/306 (19%), Positives = 109/306 (35%), Gaps = 58/306 (18%) Query: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ--DCPKARREVELHWR-ASQCPH 116 +D+ K+ +++G G G V + + A+K+ + E ++ + + Sbjct: 12 LDNLKLL-ELIGRGRYGAVYKG--SLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDN 68 Query: 117 IVR-IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 I R IV GR L+VME G L + + + + S+ + Sbjct: 69 IARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVS---SCRLAHSVTRGLA 125 Query: 176 YLHSI---------NIAHRDVKPENLLYTSKRPNAILKLTDFGFA---------KETTSH 217 YLH+ I+HRD+ N+L + + ++DFG + + Sbjct: 126 YLHTELPRGDHYKPAISHRDLNSRNVLV---KNDGTCVISDFGLSMRLTGNRLVRPGEED 182 Query: 218 NSLTTPCYTPYYVAPEVLGP-------EKYDKSCDMWSLGVIMYILLCGYP-PFYSNHGL 269 N+ + T Y+APEVL E K DM++LG+I + + F Sbjct: 183 NAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVP 242 Query: 270 AISPGMKTRI---------------RMGQYEFPNPEWSEVSEEVKML---IRNLLKTEPT 311 +T + + +FP W E S V+ L I + + Sbjct: 243 EYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPE-AWKENSLAVRSLKETIEDCWDQDAE 301 Query: 312 QRMTIT 317 R+T Sbjct: 302 ARLTAQ 307 >4TN6-A nrPDB Length = 318 Score = 142 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 50/265 (18%), Positives = 94/265 (35%), Gaps = 22/265 (8%) Query: 59 IIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALK---MLQDCPKARREVELHWRASQCP 115 + + Y++ + +G G G + + E+ A+K + P+ E +++ Sbjct: 5 VGNRYRL-GRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGV 63 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 I I A ++VME L G + + + F+ + + + I+ Sbjct: 64 GIPTI----RWCGAEGDYNVMVMELL--GPSLEDLFNFCSRKFSLKTVLLLADQMISRIE 117 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS--------HNSLTTPCYTP 227 Y+HS N HRDVKP+N L + ++ + DFG AK+ + T Sbjct: 118 YIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTA 177 Query: 228 YYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 Y + + + D+ SLG ++ G P+ A RI + P Sbjct: 178 RYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKA-ATKRQKYERISEKKMSTP 236 Query: 288 NPE-WSEVSEEVKMLIRNL--LKTE 309 E + L+ + Sbjct: 237 IEVLCKGYPSEFATYLNFCRSLRFD 261 >3SOC-A nrPDB Length = 322 Score = 140 bits (353), Expect = 1e-33, Method: Composition-based stats. Identities = 52/281 (18%), Positives = 103/281 (36%), Gaps = 44/281 (15%) Query: 72 LGINGKVLQIFNKRTQEKFALKM--LQDCPKARREVELH-WRASQCPHIVRIVDVYENLY 128 G G V + E A+K+ +QD + E E++ + +I++ + + Sbjct: 34 RGRFGCVWKAQLL--NEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGT 91 Query: 129 AGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI-------- 180 + L ++ + G L ++ + E I +++ + YLH Sbjct: 92 SVDVDLWLITAFHEKGSLSDFLKA---NVVSWNELCHIAETMARGLAYLHEDIPGLKDGH 148 Query: 181 --NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS---LTTPCYTPYYVAPEVL 235 I+HRD+K +N+L + N + DFG A + + S T Y+APEVL Sbjct: 149 KPAISHRDIKSKNVLL---KNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVL 205 Query: 236 GP-----EKYDKSCDMWSLGVIMYILLCGYP-----------PFYSNHGLAISPGMKTRI 279 DM+++G++++ L PF G S + Sbjct: 206 EGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEV 265 Query: 280 RMGQYEFP-NPEWSEVSEEVKML---IRNLLKTEPTQRMTI 316 + + + P ++ + + ML I + R++ Sbjct: 266 VVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSA 306 >3SV0-A nrPDB Length = 483 Score = 138 bits (348), Expect = 4e-33, Method: Composition-based stats. Identities = 53/261 (20%), Positives = 101/261 (38%), Gaps = 38/261 (14%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEKFALK---MLQDCPKARREVELHWRASQCPHI--VRI 120 + +G G G++ N +T E+ A+K + P+ E +++ I VR Sbjct: 11 LGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHPQLLYESKIYRILQGGTGIPNVRW 70 Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 V ++VM+ L G + + + + + + + ++++HS Sbjct: 71 FGV------EGDYNVLVMDLL--GPSLEDLFNFCSRKLSLKTVLMLADQMINRVEFVHSK 122 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS--------HNSLTTPCYTPYYVAP 232 + HRD+KP+N L R + + DFG AK+ + T Y + Sbjct: 123 SFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTARYASV 182 Query: 233 EVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWS 292 + + D+ SLG ++ L G P+ G+K + +YE Sbjct: 183 NTHLGIEQSRRDDLESLGYVLMYFLRGSLPW---------QGLKAGTKKQKYE------- 226 Query: 293 EVSE-EVKMLIRNLLKTEPTQ 312 ++SE +V I L + PT+ Sbjct: 227 KISEKKVATSIEALCRGYPTE 247 >2PZI-A nrPDB Length = 681 Score = 137 bits (345), Expect = 8e-33, Method: Composition-based stats. Identities = 70/299 (23%), Positives = 110/299 (36%), Gaps = 47/299 (15%) Query: 57 NAIIDDYKVTSQVLGLGINGKVLQIFNKR-TQEKFALKML-----QDCPKARREVELHWR 110 + + Y+V + G G + ++ LK L + Sbjct: 76 DIVAGQYEVKG-CIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLA 134 Query: 111 ASQCPHIVRIVDVYENLYAGRKCL-LIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 169 P IV+I + E+ + IVME + G L + Q EA + Sbjct: 135 EVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSL----KRSKGQKLPVAEAIAYLLE 190 Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYY 229 I A+ YLHSI + + D+KPEN++ T ++ LKL D G S L TP + Sbjct: 191 ILPALSYLHSIGLVYNDLKPENIMLTEEQ----LKLIDLGAVSRINSFGYLY---GTPGF 243 Query: 230 VAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNP 289 APE++ + D++++G + L P R G+Y P Sbjct: 244 QAPEIVRTGP-TVATDIYTVGRTLAALTLDLP-----------------TRNGRYVDGLP 285 Query: 290 EWSEV---SEEVKMLIRNLLKTEPTQRMTITEFMN-------HPWIMQSTKVPQTPLHT 338 E V + L+R + +P QR T E M+ + Q T VP+ L T Sbjct: 286 EDDPVLKTYDSYGRLLRRAIDPDPRQRFTTAEEMSAQLTGVLREVVAQDTGVPRPGLST 344 >2CMW-A nrPDB Length = 310 Score = 136 bits (342), Expect = 2e-32, Method: Composition-based stats. Identities = 52/258 (20%), Positives = 93/258 (36%), Gaps = 32/258 (12%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYE 125 + +G G G++ N T E A+K+ P R +LH R Sbjct: 4 VGKKIGCGNFGELRLGKNLYTNEYVAIKL---EPIKSRAPQLHLEY-------RFYKQLG 53 Query: 126 NLYAGRKCLL----------IVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 + G + +V+E L G + D D+ FT + I + ++ Sbjct: 54 SAGEGLPQVYYFGPCGKYNAMVLELL--GPSLEDLFDLCDRTFTLKTVLMIAIQLLSRME 111 Query: 176 YLHSINIAHRDVKPENLLYTSK--RPNAILKLTDFGFAKETTS--------HNSLTTPCY 225 Y+HS N+ +RDVKPEN L + + ++ + DFG AKE + + Sbjct: 112 YVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTG 171 Query: 226 TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYE 285 T Y++ ++ + D+ +LG + L G P+ + + + Sbjct: 172 TARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNT 231 Query: 286 FPNPEWSEVSEEVKMLIR 303 EE+ +R Sbjct: 232 PIEALCENFPEEMATYLR 249 >5FQD-C nrPDB Length = 341 Score = 135 bits (339), Expect = 5e-32, Method: Composition-based stats. Identities = 51/240 (21%), Positives = 86/240 (35%), Gaps = 25/240 (10%) Query: 62 DYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC---PKARREVELHWRASQ---CP 115 YK+ + +G G G + N E+ A+K+ P+ E +L+ P Sbjct: 20 KYKLVRK-IGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIP 78 Query: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 HI + ++VM+ L G + + + FT + + + I+ Sbjct: 79 HI-------RWYGQEKDYNVLVMDLL--GPSLEDLFNFCSRRFTMKTVLMLADQMISRIE 129 Query: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS--------HNSLTTPCYTP 227 Y+H+ N HRD+KP+N L R L L DFG AK+ + T Sbjct: 130 YVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTA 189 Query: 228 YYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 Y + + + DM SLG ++ P+ A +I + P Sbjct: 190 RYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKA-ATKKQKYEKISEKKMSTP 248 >1CSN-A nrPDB Length = 298 Score = 133 bits (336), Expect = 1e-31, Method: Composition-based stats. Identities = 45/261 (17%), Positives = 94/261 (36%), Gaps = 20/261 (7%) Query: 55 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALK---MLQDCPKARREVELHWRA 111 + N + YKV + +G G G + + N ++ A+K D P+ R E + Sbjct: 4 QNNVVGVHYKV-GRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDEYRTYKLL 62 Query: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 + C I + + ++V++ L G + D + F+ + + K + Sbjct: 63 AGCTGIPNVYYFGQEGLHN----VLVIDLL--GPSLEDLLDLCGRKFSVKTVAMAAKQML 116 Query: 172 EAIQYLHSINIAHRDVKPENLLYT--SKRPNAILKLTDFGF--------AKETTSHNSLT 221 +Q +H ++ +RD+KP+N L + + ++ + DFG K+ + Sbjct: 117 ARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKK 176 Query: 222 TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRM 281 T Y++ + + D+ +LG + L G P+ + Sbjct: 177 NLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIGEK 236 Query: 282 GQYEFPNPEWSEVSEEVKMLI 302 Q + EE + Sbjct: 237 KQSTPLRELCAGFPEEFYKYM 257 >2CHL-A nrPDB Length = 351 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 51/251 (20%), Positives = 93/251 (37%), Gaps = 20/251 (7%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEKFALK---MLQDCPKARREVELHWRASQCPHIVRIVD 122 + +G G G++ N T E A+K M P+ E + + I ++ Sbjct: 34 VGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQVYY 93 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182 K +V+E L G + D D+ F+ + I + ++Y+HS N+ Sbjct: 94 F----GPCGKYNAMVLELL--GPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNL 147 Query: 183 AHRDVKPENLLYT--SKRPNAILKLTDFGFAKETTS--------HNSLTTPCYTPYYVAP 232 +RDVKPEN L + ++ + DF AKE + + T Y++ Sbjct: 148 IYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSI 207 Query: 233 EVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWS 292 ++ + D+ +LG + L G P+ + +I + P Sbjct: 208 NTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTL-KERYQKIGDTKRATPIEVLC 266 Query: 293 EVSEEVKMLIR 303 E E+ +R Sbjct: 267 ENFPEMATYLR 277 >4Y12-A nrPDB Length = 375 Score = 133 bits (334), Expect = 2e-31, Method: Composition-based stats. Identities = 64/274 (23%), Positives = 101/274 (36%), Gaps = 40/274 (14%) Query: 57 NAIIDDYKVTSQVLGLGINGKVLQIFNKR-TQEKFALKML-----QDCPKARREVELHWR 110 + + Y+V + G G + ++ LK L + Sbjct: 115 DIVAGQYEVKG-CIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLA 173 Query: 111 ASQCPHIVRIVDVYENLYAGRKCL-LIVMECLDGGELFSRIQDRGDQAFTEREASEIMKS 169 P IV+I + E+ + IVME + G L + Q EA + Sbjct: 174 EVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSL----KRSKGQKLPVAEAIAYLLE 229 Query: 170 IGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYY 229 I A+ YLHSI + + D+KPEN++ T ++ LKL D G S L TP + Sbjct: 230 ILPALSYLHSIGLVYNDLKPENIMLTEEQ----LKLIDLGAVSRINSFGYLY---GTPGF 282 Query: 230 VAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNP 289 APE++ + D++++G + L P R G+Y P Sbjct: 283 QAPEIVRTGP-TVATDIYTVGRTLAALTLDLP-----------------TRNGRYVDGLP 324 Query: 290 EWSEV---SEEVKMLIRNLLKTEPTQRMTITEFM 320 E V + L+R + +P QR T E M Sbjct: 325 EDDPVLKTYDSYGRLLRRAIDPDPRQRFTTAEEM 358 >2C47-A nrPDB Length = 313 Score = 131 bits (331), Expect = 3e-31, Method: Composition-based stats. Identities = 48/251 (19%), Positives = 92/251 (36%), Gaps = 19/251 (7%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEKFALK---MLQDCPKARREVELHWRASQCPHIVRIVD 122 + +G G G++ N T E A+K + P+ E + + S + ++ Sbjct: 8 VGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYY 67 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182 K +V+E L G + D D+ FT + I + ++Y+H+ ++ Sbjct: 68 F----GPCGKYNAMVLELL--GPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSL 121 Query: 183 AHRDVKPENLLYT--SKRPNAILKLTDFGFAKETTS--------HNSLTTPCYTPYYVAP 232 +RDVKPEN L + + + DFG AKE + + T Y++ Sbjct: 122 IYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSI 181 Query: 233 EVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWS 292 ++ + D+ +LG + L G P+ + + + Sbjct: 182 NTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCE 241 Query: 293 EVSEEVKMLIR 303 EE+ +R Sbjct: 242 NFPEEMATYLR 252 >4NT4-A nrPDB Length = 312 Score = 131 bits (331), Expect = 3e-31, Method: Composition-based stats. Identities = 54/256 (21%), Positives = 92/256 (35%), Gaps = 23/256 (8%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEKFALKM---LQDCPKARREVELHWRASQC-----PHI 117 + +G G G++ N E A+KM P+ E + I Sbjct: 16 VGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAPDGI 75 Query: 118 VRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYL 177 RI Y G + +V+E L G + + + F+ + I K + I+Y+ Sbjct: 76 PRI---YHLGTCGGRYNAMVLELL--GLSLEDLFNICARKFSLKTVLMIAKQLLHRIEYV 130 Query: 178 HSINIAHRDVKPENLLY--TSKRPNAILKLTDFGFAKETTS--------HNSLTTPCYTP 227 HS ++ +RDVKPEN L TS + I+ + DFG AKE + + T Sbjct: 131 HSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTA 190 Query: 228 YYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 Y++ + + D+ +LG + L G P+ + + + Sbjct: 191 RYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPI 250 Query: 288 NPEWSEVSEEVKMLIR 303 EE +R Sbjct: 251 EVLCDGHPEEFATYLR 266 >6BFN-A nrPDB Length = 342 Score = 130 bits (326), Expect = 1e-30, Method: Composition-based stats. Identities = 49/214 (22%), Positives = 81/214 (37%), Gaps = 33/214 (15%) Query: 70 LGLGINGKVLQIFNKRTQEKFALKMLQD---------CPKARREVELHWRASQCPHIVRI 120 +G G G V + + T +A+K L++ EVE R + P+IV Sbjct: 30 IGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSR-FRHPNIVDF 86 Query: 121 VDVYENLYAGRKCLLIVMECLDGGELFSRIQ--DRGDQAFTEREASEIMKSIGEAIQYLH 178 A +V L G L R+ + + + +I+ AIQ+LH Sbjct: 87 AGYC----AQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLH 142 Query: 179 --SINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK----------ETTSHNSLTTPCYT 226 S ++ H D+K N+L + KL DFG A+ +++ T T Sbjct: 143 QDSPSLIHGDIKSSNVLLDER---LTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGT 199 Query: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGY 260 Y+ E + + D +S GV++ L G Sbjct: 200 LAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 233 >5M07-A nrPDB Length = 276 Score = 130 bits (326), Expect = 2e-30, Method: Composition-based stats. Identities = 67/288 (23%), Positives = 106/288 (36%), Gaps = 50/288 (17%) Query: 50 SGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC--------PKA 101 S + + Y V ++LG G+V + + ALK+L + Sbjct: 19 SHMALASGVTFAGYTVV-RMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRF 77 Query: 102 RREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTER 161 +RE E+ R PHI+ + D E L I M+ +DG + + DR Sbjct: 78 QRETEVAARLF-HPHILEVHDRGE----FDGQLWIAMDYVDGIDATQHMADRFPAVLPVG 132 Query: 162 EASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRP-NAILKLTDFGFAKETTSHNSL 220 E I+ ++ A+ Y H + HRDV P N++ TS+ + + L DFG A + Sbjct: 133 EVLAIVTAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ------- 185 Query: 221 TTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIR 280 P Y APE+ D D ++L + L G PP +H + P + R Sbjct: 186 ------PSYPAPELSAGADVDGRADQYALALTAIHLFAGAPPVDRSHTGPLQPPKLSAFR 239 Query: 281 MGQYEFPNPEWSEVSEEVKML---IRNLLKTEPTQRMT----ITEFMN 321 ++ L + L T P R + MN Sbjct: 240 ---------------PDLARLDGVLSRALATAPADRFGSCREFADAMN 272 >5X18-A nrPDB Length = 295 Score = 129 bits (324), Expect = 3e-30, Method: Composition-based stats. Identities = 46/256 (17%), Positives = 97/256 (37%), Gaps = 30/256 (11%) Query: 63 YKVTSQVLGLGINGKVLQIFNKRTQEKFALK---MLQDCPKARREVELHWRASQCPHIVR 119 + + +G G G + + N A+K + P+ R E + + + P+I Sbjct: 8 HYKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRDEYKTYKILNGTPNIPY 67 Query: 120 IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHS 179 + ++V++ L G + D + F+ + ++ + I+ LH+ Sbjct: 68 AYYFGQEGLHN----ILVIDLL--GPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHA 121 Query: 180 INIAHRDVKPENLLYT--SKRPNAILKLTDFGFAKETTS--------HNSLTTPCYTPYY 229 ++ +RD+KP+N L + + L DFG AK+ + + T Y Sbjct: 122 HDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARY 181 Query: 230 VAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNP 289 ++ + + DM +LG + + L G+ P+ L + ++G+ Sbjct: 182 MSINTHLGREQSRRDDMEALGHVFFYFLRGHLPWQG---LKAPNNKQKYEKIGE------ 232 Query: 290 EWSEVSEEVKMLIRNL 305 + S V L + L Sbjct: 233 --KKRSTNVYDLAQGL 246 >2QLU-A nrPDB Length = 314 Score = 128 bits (321), Expect = 6e-30, Method: Composition-based stats. Identities = 50/282 (17%), Positives = 95/282 (33%), Gaps = 45/282 (15%) Query: 72 LGINGKVLQIFNKRTQEKFALKM--LQDCPKARREVELHWR-ASQCPHIVRIVDVYENLY 128 G G V + + A+K+ LQD + E E+ + ++++ + + Sbjct: 25 RGRFGCVWKAQLM--NDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGS 82 Query: 129 AGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI-------- 180 L ++ D G L ++ T E + +++ + YLH Sbjct: 83 NLEVELWLITAFHDKGSLTDYLK---GNIITWNELCHVAETMSRGLSYLHEDVPWCRGEG 139 Query: 181 ---NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSH---NSLTTPCYTPYYVAPEV 234 +IAHRD K +N+L + + L DFG A T Y+APEV Sbjct: 140 HKPSIAHRDFKSKNVLL---KSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEV 196 Query: 235 LGP-----EKYDKSCDMWSLGVIMYILLCGY-----------PPFYSNHGLAIS-PGMKT 277 L DM+++G++++ L+ PF G S ++ Sbjct: 197 LEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQE 256 Query: 278 RIRMGQYEFPNPEWSEVSEEVKML---IRNLLKTEPTQRMTI 316 + + + + L I + R++ Sbjct: 257 VVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSA 298 >4MWI-A nrPDB Length = 294 Score = 124 bits (311), Expect = 8e-29, Method: Composition-based stats. Identities = 43/250 (17%), Positives = 91/250 (36%), Gaps = 30/250 (12%) Query: 90 FALKMLQD---------CPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMEC 140 A+K+ + +E++ + + P+I+RI + + IVME Sbjct: 50 VAIKVFKKLQAGSIAIVRQTFNKEIKTMKK-FESPNILRIFGICIDETVTPPQFSIVMEY 108 Query: 141 LDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI--AHRDVKPENLLYTSKR 198 + G L + D T + ++ + LH H ++ N L T Sbjct: 109 CELGTLRELLDREKD--LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGY 166 Query: 199 PNAILKLTDFGFAK-----ETTSHNSLTTPCYTPYYVAPEVLGP--EKYDKSCDMWSLGV 251 +KL F K + T + Y++P+ L +YD +++S G+ Sbjct: 167 Q---VKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGI 223 Query: 252 IMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPT 311 +++ + G PF + I + + + P + E++ +I +P+ Sbjct: 224 VLWEIATGDIPFQGCNSEKIRKLVAVKRQQ------EPLGEDCPSELREIIDECRAHDPS 277 Query: 312 QRMTITEFMN 321 R ++ E + Sbjct: 278 VRPSVDEILK 287 >5J0A-A nrPDB Length = 300 Score = 123 bits (310), Expect = 1e-28, Method: Composition-based stats. Identities = 42/287 (14%), Positives = 87/287 (30%), Gaps = 39/287 (13%) Query: 68 QVLGLGINGKVLQIFNKRTQE---KFALKMLQ----------DCPKARREVELHWRASQC 114 Q LG G V + +A+K + + E ++ ++ Sbjct: 15 QKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKI-LKSLHH 73 Query: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDR---GDQAFTEREASEIMKSIG 171 P+IV E L + ME L I++R F ++ ++ Sbjct: 74 PNIVGYRAFTEA---NDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMA 130 Query: 172 EAIQYLHS-INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTP----CYT 226 ++YLH + H D+K N++ +K+ D G + + +T P T Sbjct: 131 RGLKYLHQEKKLLHGDIKSSNVVIKGDFET--IKICDVGVSLPLDENMEVTDPEACYIGT 188 Query: 227 PYYVAPEVLGPEKY-DKSCDMWSLGVIMYILLCGYPPFYSNHGL-----------AISPG 274 + E + D+++ G+ ++ ++ P + Sbjct: 189 EPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDE 248 Query: 275 MKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMN 321 + E E ++V L +P R + + Sbjct: 249 AYYAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVE 295 >5USZ-A nrPDB Length = 289 Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats. Identities = 48/275 (17%), Positives = 98/275 (35%), Gaps = 33/275 (12%) Query: 65 VTSQVLGLGINGKVLQIFNKRTQE-------KFALKMLQDCPKARRE----VELHWRASQ 113 + ++ LG G K+ + + + + LK+L + E Sbjct: 11 IFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLS 70 Query: 114 CPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEA 173 H+V V ++V E + G L + ++ + E+ K + A Sbjct: 71 HKHLVLNYGVC----VCGDENILVQEFVKFGSLDTYLKKNKN-CINILWKLEVAKQLAAA 125 Query: 174 IQYLHSINIAHRDVKPENLLYTSKRPNAI-----LKLTDFGFAKETTSHNSLTTPCYTPY 228 + +L + H +V +N+L + +KL+D G + + L Sbjct: 126 MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERI---P 182 Query: 229 YVAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 +V PE + P+ + + D WS G ++ + G A+ K + +++ P Sbjct: 183 WVPPECIENPKNLNLATDKWSFGTTLWEICSG----GDKPLSALDSQRKLQFYEDRHQLP 238 Query: 288 NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNH 322 P+ + E+ LI N + EP R + + Sbjct: 239 APKAA----ELANLINNCMDYEPDHRPSFRAIIRD 269 >4XHH-A nrPDB Length = 403 Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats. Identities = 43/263 (16%), Positives = 90/263 (34%), Gaps = 23/263 (8%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEKFALK---MLQDCPKARREVELHWRASQCPHIVRIVD 122 + +G G G + N + E+ A++ + P+ E ++ S I Sbjct: 11 IGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYKYLSGGVGI----P 66 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182 + +V++ L G + + + F+ + + + +QY+H + Sbjct: 67 FIRWFGREGEYNAMVIDLL--GPSLEDLFNYCHRKFSFKTVIMLALQMICRVQYIHGRSF 124 Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS--------HNSLTTPCYTPYYVAPEV 234 HRD+KP+N L R + + + DFG +K+ + + T Y + Sbjct: 125 IHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNT 184 Query: 235 LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE-WSE 293 + + D+ SLG ++ G P+ RI + + Sbjct: 185 HLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKA-TTKKQKYDRILEKKLCISVETLCAG 243 Query: 294 VSEEVKMLIRNL--LKTEPTQRM 314 + E + LK + +R Sbjct: 244 LPLEFSEYMNYCRNLKFD--ERP 264 >4BTF-A nrPDB Length = 469 Score = 122 bits (306), Expect = 3e-28, Method: Composition-based stats. Identities = 45/248 (18%), Positives = 87/248 (35%), Gaps = 28/248 (11%) Query: 90 FALKMLQDCP---------KARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMEC 140 +K+ + E++ + P+I+RI + + IVME Sbjct: 221 VTIKVFNNPQAESVGIVRFTFNDEIKTMKK-FDSPNILRIFGICIDQTVKPPEFSIVMEY 279 Query: 141 LDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPN 200 + G L + D T S ++ + LH HR++ + L Sbjct: 280 CELGTLRELLDREKD--LTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQ- 336 Query: 201 AILKLTDFGFAKETTS-----HNSLTTPCYTPYYVAPEVLGP--EKYDKSCDMWSLGVIM 253 +KL F +K S ++ + YV+PE L YD +++S G+++ Sbjct: 337 --VKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVL 394 Query: 254 YILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQR 313 + + G PF I + + P + E ++ +I EP+QR Sbjct: 395 WEIATGKIPFEGCDSKKIRELVAEDKKQ------EPVGQDCPELLREIINECRAHEPSQR 448 Query: 314 MTITEFMN 321 ++ + Sbjct: 449 PSVDGILE 456 >4M69-B nrPDB Length = 283 Score = 122 bits (306), Expect = 3e-28, Method: Composition-based stats. Identities = 45/248 (18%), Positives = 87/248 (35%), Gaps = 28/248 (11%) Query: 90 FALKMLQDCP---------KARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMEC 140 +K+ + E++ + P+I+RI + + IVME Sbjct: 35 VTIKVFNNPQAESVGIVRFTFNDEIKTMKK-FDSPNILRIFGICIDQTVKPPEFSIVMEY 93 Query: 141 LDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPN 200 + G L + D T S ++ + LH HR++ + L Sbjct: 94 CELGTLRELLDREKD--LTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQ- 150 Query: 201 AILKLTDFGFAKETTS-----HNSLTTPCYTPYYVAPEVLGP--EKYDKSCDMWSLGVIM 253 +KL F +K S ++ + YV+PE L YD +++S G+++ Sbjct: 151 --VKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVL 208 Query: 254 YILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQR 313 + + G PF I + + P + E ++ +I EP+QR Sbjct: 209 WEIATGKIPFEGCDSKKIRELVAEDKKQ------EPVGQDCPELLREIINECRAHEPSQR 262 Query: 314 MTITEFMN 321 ++ + Sbjct: 263 PSVDGILE 270 >4L00-A nrPDB Length = 304 Score = 121 bits (303), Expect = 6e-28, Method: Composition-based stats. Identities = 57/281 (20%), Positives = 102/281 (36%), Gaps = 43/281 (15%) Query: 65 VTSQVLGLGI-----NGKVL-----QIFNKRTQEKFALKML----QDCPKARREVELHWR 110 V + LG G +G ++ + ++ + K LK+L +D A E R Sbjct: 28 VQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMR 87 Query: 111 ASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 HIV + V ++V E ++GG L + + D T ++ K + Sbjct: 88 QVSHKHIVYLYGVCVRDVEN----IMVEEFVEGGPLDLFMHRKSD-VLTTPWKFKVAKQL 142 Query: 171 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAI----LKLTDFGFAKETTSHNSLTTPCYT 226 A+ YL ++ H +V +NLL + ++ +KL+D G S Sbjct: 143 ASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERI-- 200 Query: 227 PYYVAPEVLGPEK-YDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQY 284 ++APE + K + D WS G ++ + G P +K + + + Sbjct: 201 -PWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIP------------LKDKTLIEKE 247 Query: 285 EFPNPEWSEVSEEVK---MLIRNLLKTEPTQRMTITEFMNH 322 F V+ K L+ + +P QR M Sbjct: 248 RFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRD 288 >4XHL-A nrPDB Length = 394 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 44/243 (18%), Positives = 89/243 (36%), Gaps = 26/243 (10%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEKFALK---MLQDCPKARREVELHWRASQCPHIVRIVD 122 + +G G G + N + E+ A++ + P+ E ++ S I Sbjct: 11 IGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYRYLSGGVGI----P 66 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182 + +V++ L G + + + F+ + + + IQY+H + Sbjct: 67 FIRWFGREGEYNAMVIDLL--GPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQYIHGRSF 124 Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTS--------HNSLTTPCYTPYYVAPEV 234 HRD+KP+N L R + + + DFG +K+ + + T Y + Sbjct: 125 IHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNT 184 Query: 235 LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEV 294 + + D+ SLG ++ G P+ G+K + +Y+ + V Sbjct: 185 HLGIEQSRRDDLESLGYVLIYFCKGSLPW---------QGLKATTKKQKYDRIMEKKLNV 235 Query: 295 SEE 297 S E Sbjct: 236 SVE 238 >5OAT-A nrPDB Length = 411 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 66/315 (20%), Positives = 115/315 (36%), Gaps = 77/315 (24%) Query: 66 TSQVLGLGINGKVL--QIFNKRTQEK---FALKMLQDCPKARR----------------- 103 + + G NG V ++ + T + FALKM+ + Sbjct: 15 LGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRETVPARM 74 Query: 104 ----------EVELHWRASQ---CPHIVRIVDVYENLYA-------------GRKCLLIV 137 E+EL R P+IV I V+ +LY L ++ Sbjct: 75 YYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMSLFLL 134 Query: 138 MECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT-S 196 M+ D +Q A + R + ++ + E + ++ + IAHRD+K +NLL S Sbjct: 135 MKRYDC-----NLQSFLSTAPSTRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDTS 189 Query: 197 KRPNAILKLTDFGFAKETTSHN-------SLTTPCYTPYYVAPEVLGPEK-------YDK 242 + + IL ++DFG ++ +APE++ + Y Sbjct: 190 EPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLNYS- 248 Query: 243 SCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI 302 D+W++G I Y + + PFY P + + P EV ++ L+ Sbjct: 249 KADLWAVGAIAYEIFNCHNPFYG-------PSRLKNFNYKEGDLPKLP-DEVPTVIQALV 300 Query: 303 RNLLKTEPTQRMTIT 317 NLLK P +R+ Sbjct: 301 ANLLKRNPNKRLDPE 315 >5C01-A nrPDB Length = 342 Score = 109 bits (272), Expect = 3e-24, Method: Composition-based stats. Identities = 55/300 (18%), Positives = 99/300 (33%), Gaps = 36/300 (12%) Query: 42 QFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLG--INGK------VLQIFNKRTQEKFALK 93 + Q + + + + Y+ +V G G GK ++ ++ + + LK Sbjct: 54 RVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLK 113 Query: 94 MLQ----DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSR 149 +L D A E H+ + V ++V E ++ G L Sbjct: 114 VLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVC----VRGPENIMVTEYVEHGPLDVW 169 Query: 150 IQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT----SKRPNAILKL 205 ++ + + + A+ YL + N+ H +V N+L ++ + +KL Sbjct: 170 LRRERGH-VPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKL 228 Query: 206 TDFGFAKETTSHNSLTTPCYTPYYVAPEVL--GPEKYDKSCDMWSLGVIMYI-LLCGYPP 262 +D G S ++APE L G + D W G + G P Sbjct: 229 SDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAP 285 Query: 263 FYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNH 322 S P K Q+ P P ++ L L EPTQR + + Sbjct: 286 LQSRS-----PSEKEHFYQRQHRLPEPSC----PQLATLTSQCLTYEPTQRPSFRTILRD 336 >4WOV-A nrPDB Length = 317 Score = 108 bits (271), Expect = 3e-24, Method: Composition-based stats. Identities = 55/300 (18%), Positives = 99/300 (33%), Gaps = 36/300 (12%) Query: 42 QFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLG--INGK------VLQIFNKRTQEKFALK 93 + Q + + + + Y+ +V G G GK ++ ++ + + LK Sbjct: 31 RVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLK 90 Query: 94 MLQ----DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSR 149 +L D A E H+ + V ++V E ++ G L Sbjct: 91 VLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVC----VRGPENIMVTEYVEHGPLDVW 146 Query: 150 IQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT----SKRPNAILKL 205 ++ + + + A+ YL + N+ H +V N+L ++ + +KL Sbjct: 147 LRRERGH-VPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKL 205 Query: 206 TDFGFAKETTSHNSLTTPCYTPYYVAPEVL--GPEKYDKSCDMWSLGVIMYI-LLCGYPP 262 +D G S ++APE L G + D W G + G P Sbjct: 206 SDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAP 262 Query: 263 FYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNH 322 S P K Q+ P P ++ L L EPTQR + + Sbjct: 263 LQSRS-----PSEKEHFYQRQHRLPEPSC----PQLATLTSQCLTYEPTQRPSFRTILRD 313 >4JRN-A nrPDB Length = 372 Score = 107 bits (267), Expect = 1e-23, Method: Composition-based stats. Identities = 61/325 (18%), Positives = 98/325 (30%), Gaps = 70/325 (21%) Query: 36 PPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM- 94 PP P++F + + A LG G V + + T E+ A+K+ Sbjct: 52 PPDVPKRFVSVTTGETRTLVRGAP----------LGSGGFATVYEATDVETNEELAVKVF 101 Query: 95 -------------LQDCPKARREVELHWRASQCPHIVRIVD----------------VYE 125 LQ R L A R + V Sbjct: 102 MSEKEPTDETMLDLQRESSCYRNFSLAKTAKDAQESCRFMVPSDVVMLEGQPASTEVVIG 161 Query: 126 NLYAGRKCLLIVMECLDGGELFSRIQ------DRGDQAFTEREASEIMKSIGEAIQYLHS 179 ++M + ++ I F + + + + + Sbjct: 162 LTTRWVPNYFLLMMRAEA-DMSKVISWVFGDASVNKSEFGLVVRMYLSSQAIKLVANVQA 220 Query: 180 INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPE---VLG 236 I H D+KP N L + L L DFG +NS+ TP Y PE Sbjct: 221 QGIVHTDIKPANFLL---LKDGRLFLGDFG---TYRINNSVGRAIGTPGYEPPERPFQAT 274 Query: 237 PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSE 296 Y D W LG+ +Y + C P + G+ + + E Sbjct: 275 GITYTFPTDAWQLGITLYCIWCKERP-------TPADGIWDYLHFA-------DCPSTPE 320 Query: 297 EVKMLIRNLLKTEPTQRMTITEFMN 321 V+ LIR+LL +P +RM + + Sbjct: 321 LVQDLIRSLLNRDPQKRMLPLQALE 345 >6EQI-C nrPDB Length = 433 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 64/348 (18%), Positives = 122/348 (35%), Gaps = 92/348 (26%) Query: 66 TSQVLGLGINGKVLQIFNKRTQ-----EKFALKMLQD----------CPKARREV----- 105 + + G N V K Q + A+KM+ + RE Sbjct: 19 LGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRETVPAMS 78 Query: 106 --------------ELHWRASQCPHIVRIVDVYENLYAGRKC------------------ 133 + R P+IVR+ V+ + +C Sbjct: 79 YFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRINPEGS 138 Query: 134 -----LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVK 188 L +VM+ D L ++D+ R + ++ + EA+ +++ NI+HRD+K Sbjct: 139 GRNMSLFLVMKRYDC-TLKEYLRDKTPN---MRSSILLLSQLLEAVAHMNIHNISHRDLK 194 Query: 189 PENLLYTSKRPNA--ILKLTDFGFA---KE----TTSHNSLTTPCYTPYYVAPEVLGPEK 239 +N+L +A + +TDFG K+ + +APE+ + Sbjct: 195 SDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEIANAKP 254 Query: 240 YD------KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSE 293 K D+W++G I Y + PFY +S K+ E P+ Sbjct: 255 GTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDKTMKLLS---KSYKEEDLPELPD----T 307 Query: 294 VSEEVKMLIRNLLKTEPTQRM------TITEF-MNHP--WIMQSTKVP 332 + ++ L+ N+L +R+ T+ + + P W+ ++ +P Sbjct: 308 IPFIIRNLVSNMLSRSTNKRLDCDVAATVAQLYLWAPSSWLKENYTLP 355 >5X1R-A nrPDB Length = 302 Score = 103 bits (257), Expect = 2e-22, Method: Composition-based stats. Identities = 50/296 (16%), Positives = 107/296 (36%), Gaps = 50/296 (16%) Query: 54 IKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARR---------- 103 + +++++ + +G G G V + ++ + + A+K A+R Sbjct: 14 LPSGYRFNEFEI-QEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRG 72 Query: 104 ----------------EVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELF 147 E L R S P ++ ++ +E + + G L Sbjct: 73 ERFGKTFQAGLNSFIQEARLLARFS-HPGLLHVLRFWEE----NGTAYMGTQFYSGTTLK 127 Query: 148 SRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTD 207 + +Q + + E ++ + AI +H HRD+ +N+ + +L D Sbjct: 128 N-LQAQQPEKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLL---D 183 Query: 208 FGFAK-ETTSHNSLTTPCYTPYYVAPEVLGPEKYDKS---CDMWSLGVIMYILLCGYPPF 263 FG A+ E + + T P + E + D+++LG +++ L+ G PP Sbjct: 184 FGSARKEIGNLSDETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP- 242 Query: 264 YSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRM-TITE 318 +++ ++ + P + S E+ + L +P R TI E Sbjct: 243 ----PVSVVRSIEDSYQPLTERRP----AGYSPELLRTVDRALALKPEDRPQTIDE 290 >4I94-A nrPDB Length = 300 Score = 102 bits (255), Expect = 3e-22, Method: Composition-based stats. Identities = 44/246 (17%), Positives = 86/246 (34%), Gaps = 24/246 (9%) Query: 77 KVLQIFNKRTQEKFALKMLQ-----DCPKARREVELHWRASQCPHIVRIVDVYENLYAGR 131 V + Q + A+K D + E + + R+ ++ Y Sbjct: 44 VVYKGK-LENQRRIAVKRFNRKSWPDSRQFLEEAKAVGQLRNH----RMANLLGCCYEDE 98 Query: 132 KCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN-IAHRDVKPE 190 + LLI E + L + Q + I +A++Y S + D+ Sbjct: 99 ERLLIA-EFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAY 157 Query: 191 NLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLG 250 +L+ +A +L+ FG K + S +T + PE L + ++S G Sbjct: 158 RVLFDD---DANPRLSCFGLMKNSRDGKSYSTN---LAFTPPEYLRTGRVTPESVIYSFG 211 Query: 251 VIMYILLCGY--PPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKT 308 ++ LL G PP ++ + + +F + + + E+ L L+ Sbjct: 212 TLLLDLLSGKHIPPSHALDLIRDRNIQMLMDSGLEGQFSSDDGT----ELIRLASRCLQY 267 Query: 309 EPTQRM 314 EP +R Sbjct: 268 EPRERP 273 >5UV4-A nrPDB Length = 311 Score = 99.6 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 37/205 (18%), Positives = 79/205 (38%), Gaps = 17/205 (8%) Query: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDC-PKARREVELHWRAS---QCPHIVRIVDV 123 +++G +G + +K L++ K+++E + + P++V + Sbjct: 31 EIIGRSCHGTSYKAT-LDNGYMLTVKWLKEGFAKSKKEFSREIKKLGSVRHPNLVPLRGY 89 Query: 124 YENLYAGRKCLLIVMECLDGGELFSRIQD---RGDQAFTEREASEIMKSIGEAIQYLHSI 180 Y + +++ + D L + + + R + + I I + YLH+ Sbjct: 90 YWGPKEHER--IMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHNE 147 Query: 181 NIA-HRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTT--PCYTPYYVAPEVLGP 237 + H ++K N+L + P+A++ TD+ + T Y PE Sbjct: 148 RVIPHGNIKSSNVLIQNSTPSALV--TDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSST 205 Query: 238 EKY--DKSCDMWSLGVIMYILLCGY 260 K D+++ GVI+ LL G Sbjct: 206 SKPCPSLKSDVYAFGVILLELLTGK 230 >5UU1-A nrPDB Length = 324 Score = 96.1 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 47/246 (19%), Positives = 85/246 (34%), Gaps = 34/246 (13%) Query: 51 GLQIKKNAIIDDYK----VTSQVLGLGINGKVLQIFNKRTQEKFA---LKM--------L 95 + + ++DD + V + +G G G + F EK A +K+ Sbjct: 1 SMPFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLF 60 Query: 96 QDCPKARREVE-------LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFS 148 + +R + + + I + GR +VME L G +L Sbjct: 61 SELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERL-GIDLQK 119 Query: 149 RIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDF 208 G F + ++ + + ++Y+H H D+K NLL K P+ + L D+ Sbjct: 120 ISGQNG--TFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQ-VYLADY 176 Query: 209 GFA--------KETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGY 260 G + + N T + + + + D+ LG M LCG Sbjct: 177 GLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGK 236 Query: 261 PPFYSN 266 P+ N Sbjct: 237 LPWEQN 242 >6J6I-B nrPDB Length = 351 Score = 94.6 bits (234), Expect = 6e-20, Method: Composition-based stats. Identities = 37/188 (19%), Positives = 71/188 (37%), Gaps = 22/188 (11%) Query: 83 NKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLD 142 ++ T ++ + ++ L R S + ++++ ++V E + Sbjct: 92 DEITGKR------HRVKEVYNDIVLSARMSNHSNFLQLLGCCLEF----PFPVLVFEFAE 141 Query: 143 GGELFSR---IQDRGDQAFTEREASEIMKSIGEAIQYLHS---INIAHRDVKPENLLYTS 196 G + R I + + +I K I A+ YLH+ I HRDVKP ++ Sbjct: 142 HGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLD- 200 Query: 197 KRPNAILKLTDFGFAKETTSHNSLTTP---CYTPYYVAPEVLGPEKYDKSCDMWSLGVIM 253 N KL+D F+ S T Y+ P + D++S G+ + Sbjct: 201 --KNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDPLYHKTCFVTEYTDVYSFGICL 258 Query: 254 YILLCGYP 261 +++ G P Sbjct: 259 LVIITGKP 266 >5DMZ-A nrPDB Length = 365 Score = 91.1 bits (225), Expect = 7e-19, Method: Composition-based stats. Identities = 45/269 (16%), Positives = 91/269 (33%), Gaps = 26/269 (9%) Query: 12 VPFPAPAPPPQPPTPALPHPPAQPPPPPPQ--QFPQFHVKSGLQIKKNAIIDDYKVTSQV 69 V P L P + P + P K+ Q+ + + Sbjct: 18 VGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEFQLGSKLVY-----VHHL 72 Query: 70 LGLGINGKVLQIF-----NKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVY 124 LG G +V + + + ++KF LK+ + + P + + + Sbjct: 73 LGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMERLKPSMQHMFMKF 132 Query: 125 ENLYAGRKCLLIVMECLDGGELFSRI---QDRGDQAFTEREASEIMKSIGEAIQYLHSIN 181 + + + ++V E G L + I ++ ++ + + I+ +H Sbjct: 133 YSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVHDCE 192 Query: 182 IAHRDVKPENLLY--------TSKRPNAILKLTDFGFA---KETTSHNSLTTPCYTPYYV 230 I H D+KP+N + +A L L D G + K T C T + Sbjct: 193 IIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETSGFQ 252 Query: 231 APEVLGPEKYDKSCDMWSLGVIMYILLCG 259 E+L + ++ D + + +Y +L G Sbjct: 253 CVEMLSNKPWNYQIDYFGVAATVYCMLFG 281 >4IX6-A nrPDB Length = 350 Score = 90.7 bits (224), Expect = 9e-19, Method: Composition-based stats. Identities = 62/325 (19%), Positives = 103/325 (31%), Gaps = 67/325 (20%) Query: 62 DYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREV-ELHWRASQCPH---- 116 D +V LG G G V + K Q+ LK + A E+ E + H Sbjct: 20 DIRVLPGPLGSGNFGTVFRGVFKGDQDVV-LKNAKADVMAAEELLECEMDVNYHVHANAK 78 Query: 117 --IVRIVDVYENLYAGRKCLL--IVME---CL---DGGELFSRIQDRGDQAFTEREA--- 163 R + E + + E + +G + RG A Sbjct: 79 GTCARFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACAD 138 Query: 164 -------SEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK---- 212 + M+ + ++ LH + HRDVKP N L +++ +LKL D G A Sbjct: 139 ATELGVTKKAMRELLGSLARLHECGVVHRDVKPAN-LIAAEKDGGVLKLIDLGAAALCLP 197 Query: 213 --ETTSHNSLTTPCYTPY------YVAP---------------EVLGPEKYDKSCDMWSL 249 ET ++ P Y Y+ P E P+++D WS Sbjct: 198 LPETLNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDS----WSA 253 Query: 250 GVIMYILLC-------GYPPFYSNHGLAISP-GMKTRIRMGQY-EFPNPEWSEVSEEVKM 300 G +M L G F +++ + G+Y Sbjct: 254 GCVMLQLAVVGLRTDAGLERFLADYKAVGYDVNAFRGEKSGEYGTMDFAALDANGGAGWD 313 Query: 301 LIRNLLKTEPTQRMTITEFMNHPWI 325 L + L++ E R + ++H + Sbjct: 314 LCQRLMEAERDARASCEAALSHAFF 338 >4L68-A nrPDB Length = 340 Score = 90.4 bits (223), Expect = 1e-18, Method: Composition-based stats. Identities = 39/263 (14%), Positives = 82/263 (31%), Gaps = 29/263 (11%) Query: 76 GKVLQIFNKRTQEKFALKMLQDCPKARREVELHWR---ASQCPHIVRIVDVYENLYAGRK 132 G + A+K L C RE + ++ ++ Sbjct: 54 GTTYKAL-LPDGSALAVKHLSTCKLGEREFRYEMNQLWELRHSNLAPLLGFCVVEEEK-- 110 Query: 133 CLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSIN----IAHRDVK 188 +V + + G L S + + I + +LH I H+++ Sbjct: 111 --FLVYKYMSNGTLHSLLDSNRGE-LDWSTRFRIGLGAARGLAWLH-HGCRPPILHQNIC 166 Query: 189 PENLLYTSKRPNAILKLTDFGFAKETTSHNS-----LTTPCYTPYYVAPEVLGPEKYDKS 243 +L + ++ D G A+ ++ +T YVAPE Sbjct: 167 SSVILIDE---DFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEYSTTMLASLK 223 Query: 244 CDMWSLGVIMYILLCGYPPFYSN----HGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVK 299 D++ LGV++ L G + +++ R+ + N EE+ Sbjct: 224 GDVYGLGVVLLELATGLKAVGGEGFKGSLVDWVKQLESSGRIAETFDENIRGKGHDEEIS 283 Query: 300 MLIR---NLLKTEPTQRMTITEF 319 + N + + P +R ++ + Sbjct: 284 KFVEIALNCVSSRPKERWSMFQA 306 >2RSV-A nrPDB Length = 403 Score = 87.3 bits (215), Expect = 9e-18, Method: Composition-based stats. Identities = 46/313 (14%), Positives = 100/313 (31%), Gaps = 52/313 (16%) Query: 31 PPAQPPPPPPQQFPQFHVKSGLQIKK---NAIIDDYKVTSQVLGLGINGKVLQIFNKRTQ 87 P + Q + H+ + + + ++KV +G G G + ++ Sbjct: 9 PRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKV-GLPIGQGGFGCIYLADMNSSE 67 Query: 88 EK-----FALKM-----------LQDCPKARREVELHW----RASQCPHIVRIVDVYENL 127 +K+ L+ +A + ++ R + + + + Sbjct: 68 SVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHD 127 Query: 128 YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDV 187 G+ ++M+ G +I + + F+ + ++ I + ++Y+H H D+ Sbjct: 128 KNGKSYRFMIMD--RFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDI 185 Query: 188 KPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPC--------YTPYYVAPEVLGPEK 239 K NLL K P+ + L D+G A T + + + Sbjct: 186 KASNLLLNYKNPDQ-VYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVA 244 Query: 240 YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVK 299 + D+ LG M L G+ P+ N + R +Y E + Sbjct: 245 PSRRGDLEILGYCMIQWLTGHLPWEDN----LKDPKYVRDSKIRYR----------ENIA 290 Query: 300 MLIRNLLKTEPTQ 312 L+ P + Sbjct: 291 SLMDKCF---PEK 300 >2LAV-A nrPDB Length = 361 Score = 86.5 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 46/313 (14%), Positives = 100/313 (31%), Gaps = 52/313 (16%) Query: 31 PPAQPPPPPPQQFPQFHVKSGLQIKK---NAIIDDYKVTSQVLGLGINGKVLQIFNKRTQ 87 P + Q + H+ + + + ++KV +G G G + ++ Sbjct: 2 PRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKV-GLPIGQGGFGCIYLADMNSSE 60 Query: 88 EK-----FALKM-----------LQDCPKARREVELHW----RASQCPHIVRIVDVYENL 127 +K+ L+ +A + ++ R + + + + Sbjct: 61 SVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHD 120 Query: 128 YAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDV 187 G+ ++M+ G +I + + F+ + ++ I + ++Y+H H D+ Sbjct: 121 KNGKSYRFMIMD--RFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDI 178 Query: 188 KPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPC--------YTPYYVAPEVLGPEK 239 K NLL K P+ + L D+G A T + + + Sbjct: 179 KASNLLLNYKNPDQ-VYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVA 237 Query: 240 YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVK 299 + D+ LG M L G+ P+ N + R +Y E + Sbjct: 238 PSRRGDLEILGYCMIQWLTGHLPWEDN----LKDPKYVRDSKIRYR----------ENIA 283 Query: 300 MLIRNLLKTEPTQ 312 L+ P + Sbjct: 284 SLMDKCF---PEK 293 >6EWX-A nrPDB Length = 484 Score = 83.8 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 49/284 (17%), Positives = 97/284 (34%), Gaps = 59/284 (20%) Query: 125 ENLYAGRKCLLIVMECLDGGELFSRIQD-----RGDQAFTEREASEIMKSIGEAIQYLHS 179 + C++++ + ++D R + ER ++ + +++L Sbjct: 169 HTPAQEQDCVVVITREVPHQTASDFVRDSVASHRAEPEVYERRVCFLLLQLCNGLEHLKE 228 Query: 180 INIAHRDVKPENLLYTSKRPNA-------------------------------------- 201 I HRD+ ENLL P + Sbjct: 229 HGIIHRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCPSAAPAATTACQGGPGEKHLP 288 Query: 202 ILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYP 261 L +++F AK+ + + +APE++ +Y + D + G+++Y LL Sbjct: 289 RLIISNFLKAKQKPGGTTNLQQKKSQARLAPEIVSASQY-RKFDEFQTGILIYELLHQPN 347 Query: 262 PFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMN 321 PF L + + P P S S ++ L LL+ +P +R+ I E Sbjct: 348 PFEVRAQLRERDYRREDL------PPLPTLSLYSPGLQQLAHLLLEADPIKRIRIGEAKR 401 Query: 322 HPWIMQ------STKVPQTPLHTSRVLKEDKERWEDVKEEMTSA 359 ++Q ++ + P + VL W D+K + Sbjct: 402 ---VLQCLLWGPRRELVEQPCPSEEVLCNTLHNWIDMKRALMMM 442 >5CLR-A nrPDB Length = 451 Score = 80.7 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 39/220 (17%), Positives = 81/220 (36%), Gaps = 24/220 (10%) Query: 68 QVLGLG-INGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYEN 126 ++ G G + +++ + + LK ++ ++ E R+V + N Sbjct: 84 KISGGGKSYCEQFKVYALDDGKTYFLKSVKIDAESLTEFTNEKDTLSKLG--RLVGTFFN 141 Query: 127 LYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTER-----EASEIMKSIGEAIQYLHSIN 181 + I+ + G +L + E IM S+ ++ H + Sbjct: 142 --EQTQVHYILTTFIKGIDLSRY---KNALPLNVNLKHFWEVLGIMISVCHQVKQFHELG 196 Query: 182 IAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEK-- 239 + HRD+KP N++ + + L DFG + + T Y+APE+ E Sbjct: 197 LIHRDLKPGNIMLDA---DMQCHLVDFGSSSSDKEPKPAS--WGTASYLAPELNAQEDFI 251 Query: 240 -YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTR 278 + + D+++L + L PF + G+K + Sbjct: 252 AFSQVSDLFALAYSLDELF---NPFRQVKFAKVDIGIKNK 288 >6BHC-A nrPDB Length = 438 Score = 79.2 bits (194), Expect = 3e-15, Method: Composition-based stats. Identities = 49/273 (17%), Positives = 105/273 (38%), Gaps = 53/273 (19%) Query: 90 FALKMLQDCPK----------ARREVELHWRASQC--------PHIVRIVDVYENLYAGR 131 +A+K+ + K R+ + +H+ Q P+ R++ + R Sbjct: 86 YAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPN--RLLPWEDPSKKQR 143 Query: 132 KCLLIVMECLDGGELFSRIQDRGDQA-----FTEREASEIMKSIGEAIQYLHSINIAHRD 186 ++++ + + ++D Q ER+ ++ + +++L ++ H D Sbjct: 144 SHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCD 203 Query: 187 VKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT-------------PY----- 228 ++ ENLL +P + FG A+ T + + T + P Sbjct: 204 LRLENLLLVHYQPGGTAQ--GFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQ 261 Query: 229 -YVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 +APE++ +Y K CD + G+++Y +L PF N L + + + P Sbjct: 262 SRLAPEIITATQY-KKCDEFQTGILIYEMLHLPNPFDENPELKEREYTRADLPRIPFRSP 320 Query: 288 NPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM 320 S ++ L LL P++R+ I++ Sbjct: 321 ------YSRGLQQLASCLLNPNPSERILISDAK 347 >4CI6-B nrPDB Length = 643 Score = 78.0 bits (191), Expect = 7e-15, Method: Composition-based stats. Identities = 45/280 (16%), Positives = 96/280 (34%), Gaps = 38/280 (13%) Query: 107 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDG----GELFSRIQDRGDQAFT--- 159 ++ A + P++ + + Y R ++M+ +DG L S Sbjct: 94 IYKTAGKHPNLANVHGMAVVPYGNRYYYALLMDEVDGWRCSDTLRSLADSWKQGKINSEA 153 Query: 160 -EREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN 218 I + + +L I H D+KP N+++ R + + D G + S Sbjct: 154 YWGTIKFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFD--RASGEPVVIDLGL--HSRSGE 209 Query: 219 SLTTPCYTPYYVAPEV-LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMK- 276 T + APE+ +G + D++ +++ LL G F + + + G++ Sbjct: 210 QPKGF--TESFKAPELGVGNLGASEKSDVF---LVVSTLLHGIEGFEKDPEIKPNQGLRF 264 Query: 277 ------TRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTK 330 + Y P + V I ++L R E H ++ T Sbjct: 265 ITSEPAHVMDENGYPIHRPGIAGVETAYTRFITDILGVSADSRPDSNEARLHEFLSDGTI 324 Query: 331 VPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQI 370 ++ + +K+ +T ++ + D +I Sbjct: 325 DEESAK-------------QILKDTLTGEMSPLPTDVRRI 351 >4O1O-A nrPDB Length = 717 Score = 76.1 bits (186), Expect = 3e-14, Method: Composition-based stats. Identities = 49/313 (15%), Positives = 104/313 (33%), Gaps = 64/313 (20%) Query: 22 QPPTPALPHPPAQPPPPPPQQFPQFH-VKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQ 80 +PP ++ H + + K ID+ + G + Sbjct: 313 RPPAENWKPQSSRWGEA----LKHLHRIWRPMIGKLKIFIDEEYKIADT----AEGGIYL 364 Query: 81 IFNKRTQEKFALKMLQD-CPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVME 139 ++ A+K + + ++EV + ++V + + CL + + Sbjct: 365 GL--YEDQEVAVKRFSEGSTRGQQEVSCLQSSRANDNVV----TFYGSESDGSCLHVCLA 418 Query: 140 CLDGGELFSRIQDRGDQAFTERE---ASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTS 196 + L + + A E A I+ S+ +AI LH +H+D++P+N+L S Sbjct: 419 LCEY-TLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDS 477 Query: 197 KRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLG-VIMYI 255 K L DF + + D+ +LG +++Y+ Sbjct: 478 KNGTF---LADFDKSIKWAEDPQKIKR---------------------DLEALGLLVLYV 513 Query: 256 LLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKT--EPTQR 313 + G F + + ++ +P+ EE + LI +L R Sbjct: 514 VKKGDISFETLKNQSFEEVIQG----------SPD-----EETRDLIHHLFHPGDNVEDR 558 Query: 314 MTITEFMNHPWIM 326 ++ + HP+ Sbjct: 559 LSS--LLAHPFFW 569 >6G4J-A nrPDB Length = 315 Score = 75.7 bits (185), Expect = 4e-14, Method: Composition-based stats. Identities = 50/213 (23%), Positives = 78/213 (36%), Gaps = 20/213 (9%) Query: 48 VKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVEL 107 +K G IK + Y + Q LG G NG V + ALK+ D EV + Sbjct: 13 LKPGTTIKGKWNGNTYTLRKQ-LGKGANGIVYLAE--TSDGHVALKVSDDSLSITSEVNV 69 Query: 108 HWRASQ------CPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTER 161 S+ P D Y + ME + G L + D+G + Sbjct: 70 LKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSFY-AMEYIKGPLLLKYVSDKGAEWIPV- 127 Query: 162 EASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLT 221 +M + ++ LH D+KP+NL+ T P A ++ D G + Sbjct: 128 ----LMIQLLSSLSVLHQQGWIFGDLKPDNLIVT--GPPARIRCIDVGGTTKEGRAIKEY 181 Query: 222 TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMY 254 T Y Y G K + S D++++ +IM Sbjct: 182 TEFYDRGYWG---YGTRKAEPSYDLFAVAMIMI 211 >5VE6-A nrPDB Length = 492 Score = 75.3 bits (184), Expect = 4e-14, Method: Composition-based stats. Identities = 41/246 (16%), Positives = 82/246 (33%), Gaps = 60/246 (24%) Query: 129 AGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREAS-----EIMKSIGEAIQYLHSINIA 183 + C++++ + ++D E EA ++ + +++L I Sbjct: 171 QEQDCVVVITREVPHQTASDFVRDSAASHQAEPEAYERRVCFLLLQLCNGLEHLKEHGII 230 Query: 184 HRDVKPENLLYTS----------------------------------------------- 196 HRD+ ENLL Sbjct: 231 HRDLCLENLLLVHCTLQAGPGPAPAPAPAPAAAAPPCSSAAPPAGGTLSPAAGPASPEGP 290 Query: 197 -KRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYI 255 ++ L +++F AK+ + +APE++ +Y + D + G+++Y Sbjct: 291 REKQLPRLIISNFLKAKQKPGGTPNLQQKKSQARLAPEIVSASQY-RKFDEFQTGILIYE 349 Query: 256 LLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMT 315 LL PF + ++ R + P P S S ++ L LL+ +P +R+ Sbjct: 350 LLHQPNPF------EVRAQLRERDYRQEDLPPLPALSLYSPGLQQLAHLLLEADPIKRIR 403 Query: 316 ITEFMN 321 I E Sbjct: 404 IGEAKR 409 >6EAS-A nrPDB Length = 308 Score = 71.9 bits (175), Expect = 5e-13, Method: Composition-based stats. Identities = 34/234 (14%), Positives = 73/234 (31%), Gaps = 29/234 (12%) Query: 96 QDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGD 155 ++ R+ + + + ++ E + + ++V E G LF + R Sbjct: 82 KENESQYRKKITNLSKVSHKNFMNLLGYCEEEHPFTR--VMVFEYAPNGTLFEHLHVREA 139 Query: 156 QAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT 215 + I I ++++H + N + + LTD FA + + Sbjct: 140 EKLDWMARLRISMGIAYCLEHMHQLQ---TPAALRNF------DSTTVYLTD-DFAAKVS 189 Query: 216 SHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMW----SLGVIMYILLCGYPPFYSNHGLAI 271 + S DM G+++ +L G P S + Sbjct: 190 DLEFWNDAKGH------NSTTNNELAFSPDMEDIVRKYGMVLLEILTGRVP-SSEDDGPL 242 Query: 272 SPGMKTRIRMGQ--YEFPNPEWSEVSEE-VKML---IRNLLKTEPTQRMTITEF 319 + G E +P E+ + L +R+ + +P +R + E Sbjct: 243 ENWVSRYFEGGMRLEELIDPSIGFFPEDTARALCEVVRSCIDRDPKKRPQMKEV 296 >4OAU-C nrPDB Length = 699 Score = 71.5 bits (174), Expect = 6e-13, Method: Composition-based stats. Identities = 62/308 (20%), Positives = 112/308 (36%), Gaps = 59/308 (19%) Query: 29 PHPPAQPPPPPPQQ----FPQFH-VKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFN 83 HPPA+ P H + + K ID+ + G + F Sbjct: 309 FHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADT----SEGGIYLGF- 363 Query: 84 KRTQEKFALKML-QDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLD 142 +++ A+K + P+A+REV + + H+V + + R L + + + Sbjct: 364 -YEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLV----TFYGSESHRGHLFVCVTLCE 418 Query: 143 GG-ELFSRIQDRGDQAFTERE-ASEIMKSIGEAIQYLH-SINIAHRDVKPENLLYTSKRP 199 E + D E E A ++ SI +A+Q LH S H+D++P+N+L SK+ Sbjct: 419 QTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKA 478 Query: 200 NAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLG-VIMYILLC 258 L DF + + EV D+ LG +++Y++ Sbjct: 479 ---AHLADFDKSIKWAGDPQ-------------EV--------KRDLEDLGRLVLYVVKK 514 Query: 259 GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITE 318 G F + ++ +P+ EE K LI L R +++ Sbjct: 515 GSISFEDLKAQSNEEVVQL----------SPD-----EETKDLIHRLFHPGEHVRDCLSD 559 Query: 319 FMNHPWIM 326 + HP+ Sbjct: 560 LLGHPFFW 567 >2JII-A nrPDB Length = 352 Score = 69.9 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 42/239 (17%), Positives = 86/239 (35%), Gaps = 24/239 (10%) Query: 87 QEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLY-----------AGRKCLL 135 ++KF+LK+ + E RA++ + + +Y K Sbjct: 75 KQKFSLKLDAKDGRLFNEQNFFQRAAKPLQVNKWKKLYSTPLLAIPTCMGFGVHQDKYRF 134 Query: 136 IVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT 195 +V+ L G L S + +ER ++ + +A+++LH H +V EN+ Sbjct: 135 LVLPSL-GRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVD 193 Query: 196 SKRPNAILKLTDFGFAKETTSHNSLTTPC--------YTPYYVAPEVLGPEKYDKSCDMW 247 + + + L +GFA +++ ++ + D+ Sbjct: 194 PEDQSQ-VTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQ 252 Query: 248 SLGVIMYILLCGYPPFYS---NHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIR 303 SLG M L G+ P+ + N + K + G + P W SE ++ ++ Sbjct: 253 SLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLK 311 >4CYJ-A nrPDB Length = 438 Score = 60.7 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 31/151 (20%), Positives = 53/151 (35%), Gaps = 19/151 (12%) Query: 78 VLQIFNKRTQEKFALKMLQDCPKARREVELH-----WRASQCPHIVRIVDVYENLYAGRK 132 V + N R +AL+ L+ + E + W+ + IV I +V+ G Sbjct: 71 VYKAQNSRNGRHYALRRLE-GYRLTNEKAILNVMKDWKKIKNASIVTIHEVFTTREFGDS 129 Query: 133 CLLIVMECLD-GGELFSRIQD-------RGDQAFTEREASEIMKSIGEAIQYLHSINIAH 184 L+ + L R A E + I A++ +HS +A Sbjct: 130 SLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTIHSNRLAA 189 Query: 185 RDVKPENLLYTSKRP-----NAILKLTDFGF 210 R ++P ++ T AIL + FG Sbjct: 190 RCLEPSKIILTDINRIRLSACAILDVVQFGM 220 >6M7Z-A nrPDB Length = 319 Score = 56.1 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 45/265 (16%), Positives = 85/265 (32%), Gaps = 61/265 (23%) Query: 92 LKMLQDCPKARRE----VELHWRASQCPHIVRIVDVYENLYAGRKCLLI--VMECLDGGE 145 +++L P+ +RE + V +Y + R LL+ + E G Sbjct: 62 VRLLSLTPEQQREGVSAKVRLINLLDPKYSVYEPYLYREILPKRSPLLLPSLGEY--RGA 119 Query: 146 LFSRIQDRGDQAF---------TEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTS 196 + I + + + + ++ A++ LH++ + HR ++ N S Sbjct: 120 FLTYIFHPLSKGLVGDMLETGRSHPDVQVLAANMVAALKSLHNLGLLHRSIEL-NSF--S 176 Query: 197 KRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYV-------APEV---------LGPEKY 240 P+ + L G T +V APE+ L ++ Sbjct: 177 VLPDGTVVLG--GLDTAAPIGTE------TRLWVGFFGQETAPEIDRNFLADLALTQGRH 228 Query: 241 DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM 300 D++SLGV + P + +R E + Sbjct: 229 TVKSDVYSLGVAF------RNLVQLLGNGNLGPEDRGAVRQDHLELLDK----------- 271 Query: 301 LIRNLLKTEPTQRMTITEFMNHPWI 325 L + +++ EP R TI E M P Sbjct: 272 LSQKMIEEEPGNRPTIEEIMKDPLF 296 >5GZA-A nrPDB Length = 290 Score = 54.5 bits (130), Expect = 7e-08, Method: Composition-based stats. Identities = 42/215 (19%), Positives = 69/215 (32%), Gaps = 52/215 (24%) Query: 68 QVLGLGINGKVLQIFNKRT-QEKFALKMLQDCPKARREV--ELHWRASQCPHIVRIVDVY 124 +++G G V +++ +K AL +L A + RA Q H+V +V V Sbjct: 31 KLIGQGA---VKKVYLSEWQGQKVALSVLSSDQYADDFLHGLSMLRALQSSHVVTLVGVC 87 Query: 125 ENLYAGRKCLLIVMECLDGGELFSR----IQDRGDQAFTEREASEIMKSIGEAIQYLHSI 180 E + + V E G + + Q+R + ++ + YLHS Sbjct: 88 E------EDAVFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLAYLHSS 141 Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT------------SHNSLTTPCY--- 225 P + + L+ F A + L C Sbjct: 142 --------PAGIRVMCDSNDLHKTLSQFLLASDMRLLANDLDALPEVEKGGLGVKCGHHE 193 Query: 226 -TPYYVAPEVLGPEK------------YDKSCDMW 247 T +VAPE L P YD+ D+W Sbjct: 194 LTGDFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >4CZY-B nrPDB Length = 429 Score = 53.4 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 22/120 (18%), Positives = 42/120 (35%), Gaps = 13/120 (10%) Query: 79 LQIFNKRTQEKFALKMLQD----CPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCL 134 + N + FAL+ ++ KA V W+ +IV + + + + G L Sbjct: 61 YKAQNNKNGRHFALRRIEGYRLTNEKAILNVTKEWKKIINANIVTVHEAFTTEFFGDSSL 120 Query: 135 LIVMECLDGGE-LFSRI--------QDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHR 185 + V + E L+ + R E + I A+ +H+ +A R Sbjct: 121 IFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAKLAAR 180 >6R5K-O nrPDB Length = 689 Score = 52.2 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 16/111 (14%), Positives = 41/111 (36%), Gaps = 7/111 (6%) Query: 79 LQIFNKRTQEKFALKMLQDCPKARR-----EVELHWRASQCPHIVRIVDVYENLYAGRKC 133 ++F+ + + LK L + K+ ++ W C ++++ D+++ G Sbjct: 311 FKVFSNYDGKAYVLKRLPNIDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGDLS 370 Query: 134 LLIVMECLDGG-ELFSRI-QDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182 + +V + L+ + T + + I +HS N+ Sbjct: 371 ICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNL 421 >4XR7-L nrPDB Length = 465 Score = 51.5 bits (122), Expect = 7e-07, Method: Composition-based stats. Identities = 16/111 (14%), Positives = 41/111 (36%), Gaps = 7/111 (6%) Query: 79 LQIFNKRTQEKFALKMLQDCPKARR-----EVELHWRASQCPHIVRIVDVYENLYAGRKC 133 ++F+ + + LK L + K+ ++ W C ++++ D+++ G Sbjct: 87 FKVFSNYDGKAYVLKRLPNIDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGDLS 146 Query: 134 LLIVMECLDGG-ELFSRI-QDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182 + +V + L+ + T + + I +HS N+ Sbjct: 147 ICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNL 197 >3Q60-A nrPDB Length = 371 Score = 49.5 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 40/202 (19%), Positives = 67/202 (33%), Gaps = 20/202 (9%) Query: 145 ELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILK 204 L RGD+ + + L S + H P+NL P+ L Sbjct: 180 TLDFVYVFRGDEGILALHI--LTAQLIRLAANLQSKGLVHGHFTPDNLFI---MPDGRLM 234 Query: 205 LTDFGFAKETTSHNSLTTPCYTPYYVAPEVLG--PEKYDKSCDMWSLGVIMYILLCGYPP 262 L D + Y E L + + + W LG+ +Y + C + P Sbjct: 235 LGD--VSALWKVGTRGPASSVPVTYAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLP 292 Query: 263 FYSNHGLAISPGMKTRIRMGQYEFPNPE------WSEVSEEVKMLIRNLLKTEPTQRMTI 316 F ++PG+K + P + + + + VK LI L + +R+ Sbjct: 293 F-----GLVTPGIKGSWKRPSLRVPGTDSLAFGSCTPLPDFVKTLIGRFLNFDRRRRLLP 347 Query: 317 TEFMNHPWIMQSTKVPQTPLHT 338 E M P +Q + L T Sbjct: 348 LEAMETPEFLQLQNEISSSLST 369 >3ENH-A nrPDB Length = 540 Score = 48.8 bits (115), Expect = 5e-06, Method: Composition-based stats. Identities = 26/157 (16%), Positives = 58/157 (36%), Gaps = 11/157 (7%) Query: 64 KVTSQVLGLGINGKVLQIFNKRTQEKFALK-MLQDCPKARREVELHWRASQCPHIVRIVD 122 K+ ++G G + + +K ++ + R ++ + R S+ R + Sbjct: 338 KIPEHLIGKGAEADIK--RDSYLDFDVIIKERVKKGYRDER-LDENIRKSRTAREARYLA 394 Query: 123 VYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINI 182 + ++ + V + + + S I + + E +I IGE + LH ++ Sbjct: 395 LVKDFGIPAPYIFDV-DLDNKRIMMSYINGKLAKDVIEDNL-DIAYKIGEIVGKLHKNDV 452 Query: 183 AHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS 219 H D+ N ++ L + DFG K + Sbjct: 453 IHNDLTTSNFIFDKD-----LYIIDFGLGKISNLDED 484 >4AZV-A nrPDB Length = 569 Score = 47.6 bits (112), Expect = 9e-06, Method: Composition-based stats. Identities = 19/75 (25%), Positives = 34/75 (45%), Gaps = 8/75 (10%) Query: 135 LIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLY 194 +VME L G L + E + +I+ S+ ++ L H DV+P N++ Sbjct: 318 WLVMEKLPGRLLSDMLAAG-----EEIDREKILGSLLRSLAALEKQGFWHDDVRPWNVMV 372 Query: 195 TSKRPNAILKLTDFG 209 +++ +L DFG Sbjct: 373 DARQ---HARLIDFG 384 >4AZW-A nrPDB Length = 471 Score = 47.6 bits (112), Expect = 9e-06, Method: Composition-based stats. Identities = 19/75 (25%), Positives = 34/75 (45%), Gaps = 8/75 (10%) Query: 135 LIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLY 194 +VME L G L + E + +I+ S+ ++ L H DV+P N++ Sbjct: 318 WLVMEKLPGRLLSDMLAAG-----EEIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMV 372 Query: 195 TSKRPNAILKLTDFG 209 +++ +L DFG Sbjct: 373 DARQ---HARLIDFG 384 >4WWA-A nrPDB Length = 261 Score = 46.5 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 26/167 (15%), Positives = 48/167 (28%), Gaps = 29/167 (17%) Query: 70 LGLGINGKV-------LQIFNKRTQEKFALKM----------LQDCPKARR---EVELHW 109 + G V K + +K+ +K + R E L Sbjct: 22 ISQGAEAIVFTTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLA 81 Query: 110 RASQCPHIVRIVDVYENLYAGRKCLLIVM--ECLDGG----ELFSRIQDRGDQAFTEREA 163 + P + V + + E L GG L + + ++ Sbjct: 82 KLYLIPGLC--VPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYS-DLV 138 Query: 164 SEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGF 210 + ++ +G I LH + H D+ N++ L DFG Sbjct: 139 ATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >4BWP-A nrPDB Length = 448 Score = 46.1 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 17/136 (12%), Positives = 40/136 (29%), Gaps = 32/136 (23%) Query: 79 LQIFNKRTQEKFALKMLQDCPKARRE---VELHWRASQCPHIVRIVDVYENLYAGRKCLL 135 + + T K+ L+ + + + W+ Q ++V++ +V+ G L+ Sbjct: 67 YRATHNTTGYKYCLRRIHGFRLQSTKCMTLVEMWKKLQHTNVVQLREVFTTKAFGDNSLV 126 Query: 136 IVMECLDG-----------------------GELFSRIQDRGDQA------FTEREASEI 166 +V + G GE Q E I Sbjct: 127 LVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEATIWSI 186 Query: 167 MKSIGEAIQYLHSINI 182 + + ++ +H + Sbjct: 187 IMQLTAGLKAIHHAGL 202 >1TQM-A nrPDB Length = 282 Score = 46.1 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 25/157 (15%), Positives = 58/157 (36%), Gaps = 28/157 (17%) Query: 66 TSQVLGLGINGKVLQIFNKRTQEKFALKM-------LQDCPKARREVELHWRASQCP--- 115 +++G G V ++++ E +K + + R +LH+ Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECV-VKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSAR 152 Query: 116 HIVRIVDVYENLYAGRKCLL----IVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 + R + + L + ++ME +D EL+ + D+ I++ + Sbjct: 153 NEFRALQKLQGLAVPKVYAWEGNAVLMELIDAKELYRVRVENPDEVLDM-----ILEEVA 207 Query: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDF 208 + + H I H D+ N+L + + + + DF Sbjct: 208 K---FYH-RGIVHGDLSQYNVLVSEEG----IWIIDF 236 >3BYV-A nrPDB Length = 377 Score = 44.5 bits (104), Expect = 8e-05, Method: Composition-based stats. Identities = 25/171 (14%), Positives = 58/171 (33%), Gaps = 29/171 (16%) Query: 164 SEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTP 223 ++ + + LH + H ++P +++ + + LT F + + Sbjct: 209 LQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQR---GGVFLTGF---EHLVRDGARVVS 262 Query: 224 CYTPYYVAPEV------LGPEK-----YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAIS 272 + + PE+ + + S D W+LG+++Y + C P + L S Sbjct: 263 SVSRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIWCADLPITKDAALGGS 322 Query: 273 PGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHP 323 + + + V+ L+ L+ R+ + M P Sbjct: 323 EWIFR------------SCKNIPQPVRALLEGFLRYPKEDRLLPLQAMETP 361 >6G38-A nrPDB Length = 357 Score = 42.2 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 27/174 (15%), Positives = 55/174 (31%), Gaps = 53/174 (30%) Query: 67 SQVLGLGINGKVLQIFNKRTQEKFALKML-------------QDCPKARREVELHWRAS- 112 + +G G+ G+V Q T A+K++ + + E+ + S Sbjct: 46 CEKIGEGVFGEVFQTIADHT--PVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSL 103 Query: 113 ------------------QC------PHIVRIVDVYENL---------YAGRKCLLIVME 139 C P +++ D Y + + L IV+E Sbjct: 104 LSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLE 163 Query: 140 CLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLH-SINIAHRDVKPENL 192 GG ++ + + A I+ + ++ S+ HRD+ N+ Sbjct: 164 FEFGG---IDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNV 214 >5GZ9-A nrPDB Length = 305 Score = 41.4 bits (96), Expect = 6e-04, Method: Composition-based stats. Identities = 41/239 (17%), Positives = 75/239 (31%), Gaps = 39/239 (16%) Query: 37 PPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQE-KFALKML 95 PP + + S + + ++ + +G G V ++F +E K AL L Sbjct: 11 PPGYFRMGRMRQCSRWLSCEELRTEVRQL--KRVGEGA---VKRVFLSEWKEHKVALSRL 65 Query: 96 QDCPKARREV--ELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSR---I 150 + ++ Q H+V +V E I+ E G L + + Sbjct: 66 TRLEMKEDFLHGLQMLKSLQSEHVVTLVGYCEEDGT------ILTEYHPLGSLSNLEETL 119 Query: 151 Q-DRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL---YTSKRPNAILKLT 206 Q + T + ++ I YLH + R + N L + + + Sbjct: 120 QLSKYQDVNTWQHRLQLAMEYVSIINYLHHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIV 179 Query: 207 --DFGFAKETTSHNSLTTPCYTPY----YVAPEVLGPEK------------YDKSCDMW 247 D + + C +VAPE L P Y++ D+W Sbjct: 180 ANDLDALPLVDHDSGVLIKCGHRELHGDFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >3J8B-F nrPDB Length = 327 Score = 41.1 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 29/140 (20%), Positives = 54/140 (38%), Gaps = 22/140 (15%) Query: 17 PAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKV----TSQVLGL 72 P PA PA P P P FP V + +I+D Y+ ++V+G Sbjct: 60 GQTPASAQAPAQTPAPALPGPALPGPFPGGRVVRLHPVILASIVDSYERRNEGAARVIGT 119 Query: 73 GINGKV----------LQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVD 122 + G V + + ++++ A+ D A+ ELH + S P+ + I+ Sbjct: 120 -LLGTVDKHSVEVTNCFSVPHNESEDEVAV----DMEFAKNMYELHKKVS--PNEL-ILG 171 Query: 123 VYENLYAGRKCLLIVMECLD 142 Y + + +++ E Sbjct: 172 WYATGHDITEHSVLIHEYYS 191 >6G18-v nrPDB Length = 552 Score = 41.1 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 27/158 (17%), Positives = 54/158 (34%), Gaps = 32/158 (20%) Query: 71 GLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDV------- 123 G+G + + N+ ++FALK+ + + R ++ + H V + + Sbjct: 102 GVGKESDIYIVANEE-GQQFALKLHRLGRTSFRNLKNKRDYHKHRHNVSWLYLSRLSAMK 160 Query: 124 --------YENLYAGRKCL-----LIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 YE + K + +VME ++G L + + I+K Sbjct: 161 EFAYMKALYERKFPVPKPIDYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVK-- 218 Query: 171 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDF 208 L + + H D NL+ + + DF Sbjct: 219 ------LANHGLIHGDFNEFNLILDESD---HITMIDF 247 >2W1Z-A nrPDB Length = 368 Score = 40.7 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 27/188 (14%), Positives = 53/188 (28%), Gaps = 30/188 (15%) Query: 146 LFSRIQDRGDQAFTERE--ASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAIL 203 L + + ++ + L + H D + N+L + + Sbjct: 174 LGDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVRNILLDQRGGVFL- 232 Query: 204 KLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPE--KY--------DKSCDMWSLGVIM 253 GF S +P + PE Y D W+LG+ + Sbjct: 233 ----TGFEHLVRDGASAVSPIG-RGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAI 287 Query: 254 YILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQR 313 Y + C P + L + R + + + V+ L+ L+ R Sbjct: 288 YWIWCADLPNTEDAELGGIEWIYRRCK------------NIPQPVRALLEGFLRYSKEDR 335 Query: 314 MTITEFMN 321 + + M Sbjct: 336 LLPLQAME 343 >3DZO-A nrPDB Length = 413 Score = 40.7 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 25/170 (14%), Positives = 53/170 (31%), Gaps = 28/170 (16%) Query: 164 SEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTP 223 ++ + + LH + H ++P +++ + + GF S +P Sbjct: 214 LQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFL-----TGFEHLVRDGASAVSP 268 Query: 224 CYTPYYVAPEVLGPEK----------YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISP 273 + PE + D W+LG+ +Y + C P + L S Sbjct: 269 IG-RGFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCADLPNTDDAALGGSE 327 Query: 274 GMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHP 323 + + + V+ L+ L+ R+ + M P Sbjct: 328 WIFR------------SCKNIPQPVRALLEGFLRYPKEDRLLPLQAMETP 365 >6FDN-A nrPDB Length = 320 Score = 39.9 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 27/158 (17%), Positives = 54/158 (34%), Gaps = 32/158 (20%) Query: 71 GLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDV------- 123 G+G + + N+ ++FALK+ + + R ++ + H V + + Sbjct: 102 GVGKESDIYIVANEE-GQQFALKLHRLGRTSFRNLKNKRDYHKHRHNVSWLYLSRLSAMK 160 Query: 124 --------YENLYAGRKCL-----LIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI 170 YE + K + +VME ++G L + + I+K Sbjct: 161 EFAYMKALYERKFPVPKPIDYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVK-- 218 Query: 171 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDF 208 L + + H D NL+ + + DF Sbjct: 219 ------LANHGLIHGDFNEFNLILDESD---HITMIDF 247 >5A5T-F nrPDB Length = 364 Score = 39.5 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 28/141 (19%), Positives = 54/141 (38%), Gaps = 22/141 (15%) Query: 16 APAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKV----TSQVLG 71 P PA P+ P P P FP V + +I+D Y+ ++V+G Sbjct: 66 TGQTPASAQAPAQTSAPSLPGPALPGPFPGGRVVRLHPVILASIVDSYERRNEGAARVIG 125 Query: 72 LGINGKV----------LQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIV 121 + G V + + ++++ A+ D A+ ELH + S P+ + I+ Sbjct: 126 T-LLGTVDKHSVEVTNCFSVPHNESEDEVAV----DMEFAKNMYELHKKVS--PNEL-IL 177 Query: 122 DVYENLYAGRKCLLIVMECLD 142 Y + + +++ E Sbjct: 178 GWYATGHDITEHSVLIHEYYS 198 >4BVU-A nrPDB Length = 211 Score = 39.5 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 36/220 (16%), Positives = 79/220 (35%), Gaps = 48/220 (21%) Query: 39 PPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC 98 P F + +G+ + + +++G G ++ + N + K Sbjct: 25 TPFPFENNNSHAGIVTEP--------ILGKLIGQGSTAEIFEDVNDSSALY---KKYDLI 73 Query: 99 PKARREV-ELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQA 157 E+ E+ W+ S +++ Y ++I GG+++ R+ Sbjct: 74 GNQYNEILEMAWQES---------ELFNAFYGDEASVVIQY----GGDVYLRMLRVPGTP 120 Query: 158 FTEREASEIMKSI----GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE 213 ++ + ++I +I + I L+ ++I H D+ N+LY + + DF Sbjct: 121 LSDIDTADIPDNIESLYLQLICKLNELSIIHYDLNTGNMLYDKESESLFP--IDF----- 173 Query: 214 TTSHNSLTTPCYTPYYVA----PEVLGPEKYDKSCDMWSL 249 Y YY A E++ ++ D +SL Sbjct: 174 --------RNIYAEYYAATKKDKEIIDRRLQMRTNDFYSL 205 >3ZO9-A nrPDB Length = 593 Score = 37.6 bits (86), Expect = 0.009, Method: Composition-based stats. Identities = 36/177 (20%), Positives = 60/177 (33%), Gaps = 59/177 (33%) Query: 207 DFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCD---------------MWSLGV 251 DFG A+ + + + +Y EVL YD + D W LGV Sbjct: 22 DFGHARTLPTDTNW--FKHAVFY---EVLVRAFYDSNADGIGDLRGLTEKLDYIKW-LGV 75 Query: 252 -IMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN-----PEWSEVSEEVKMLIRNL 305 ++ PPFY + +R G Y+ + PE+ V ++ L+ Sbjct: 76 DCLW-----LPPFYDSP-----------LRDGGYDIRDFYKVLPEFGTV-DDFVTLL--- 115 Query: 306 LKTEPTQRMTIT---EFM------NHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVK 353 + R I + + H W +S P P V + +R+ D + Sbjct: 116 ---DAAHRRGIRIITDLVMNHTSDQHEWFQESRHNPDGPYGDFYVWSDTSDRYPDAR 169 >4LXF-A nrPDB Length = 620 Score = 36.8 bits (84), Expect = 0.018, Method: Composition-based stats. Identities = 39/177 (22%), Positives = 61/177 (34%), Gaps = 59/177 (33%) Query: 207 DFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCD---------------MWSLGV 251 DFG A + + + +Y EVL +D S D W LG+ Sbjct: 49 DFGSAAALPADPTW--FKHAVFY---EVLVRAFFDASADGSGDLRGLIDRLDYLQW-LGI 102 Query: 252 -IMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPN-----PEWSEVSEEVKMLIRNL 305 ++ PPFY + +R G Y+ + PE+ V ++ L+ Sbjct: 103 DCIW-----LPPFYDSP-----------LRDGGYDIRDFYKVLPEFGTV-DDFVALV--- 142 Query: 306 LKTEPTQRMTITEF----MNH-----PWIMQSTKVPQTPLHTSRVLKEDKERWEDVK 353 + R I MNH PW +S + P P V + ER+ D + Sbjct: 143 ---DAAHRRGIRIITDLVMNHTSESHPWFQESRRDPDGPYGDYYVWSDTSERYTDAR 196 >6EF6-A nrPDB Length = 354 Score = 35.7 bits (81), Expect = 0.035, Method: Composition-based stats. Identities = 9/28 (32%), Positives = 14/28 (50%) Query: 181 NIAHRDVKPENLLYTSKRPNAILKLTDF 208 + H D++ NLL S P + + DF Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >6FAI-l nrPDB Length = 425 Score = 34.5 bits (78), Expect = 0.073, Method: Composition-based stats. Identities = 22/183 (12%), Positives = 58/183 (31%), Gaps = 33/183 (18%) Query: 50 SGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP----KARREV 105 L +K D +G+G + ++ +K + +K+ + R Sbjct: 81 DYLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNR 139 Query: 106 ELHWRASQCPHIVRI--------VDVYENLYA---------GRKCLLIVMECLDGGELFS 148 + +++Q + + + LY+ ++VME ++G + Sbjct: 140 DYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMR- 198 Query: 149 RIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSK---RPNAILKL 205 R++ + + + + + + H D N++ K + + Sbjct: 199 RLRKHKNIPKLYSDLMCFIVDLANS-------GLIHCDFNEFNIMIKDKLEDENDCGFVV 251 Query: 206 TDF 208 DF Sbjct: 252 IDF 254 >3NPK-A nrPDB Length = 291 Score = 32.6 bits (73), Expect = 0.32, Method: Composition-based stats. Identities = 12/92 (13%), Positives = 32/92 (34%), Gaps = 20/92 (21%) Query: 102 RREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGE------LFSRIQDRGD 155 +E+ +H P + + + + GG+ L S +Q Sbjct: 5 LKELFIHHLEKNLPKVESFHPFFNEA--------LALMLKAGGKHFRAQLLLSVVQSNKP 56 Query: 156 QAFTEREASEIMKSIGEAIQYLHSINIAHRDV 187 + + + A++++H+ ++ H D+ Sbjct: 57 ELLNQ------ALDVALALEFIHTYSLIHDDL 82 >5YK0-A nrPDB Length = 452 Score = 32.2 bits (72), Expect = 0.40, Method: Composition-based stats. Identities = 28/177 (15%), Positives = 54/177 (30%), Gaps = 54/177 (30%) Query: 76 GKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLL 135 G+V + + A+K+ P A + + Q R+V V + L G Sbjct: 146 GQVHKAI-WSDGREVAVKI--QYPGADEALRADLKTMQ-----RMVGVLKQLSPGADVQG 197 Query: 136 IVMECLDGGE--LFSRIQDRGDQ----------AFTEREASE-----IMKSIGEA--IQY 176 +V E ++ E L R++ + F +++ E + Sbjct: 198 VVDELVERTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVVASAPKVVIQEWIEGVPMAE 257 Query: 177 L--H----------------------SINIAHRDVKPENLLYTSKRPNAILKLTDFG 209 + H + + H D P N + P+ + + DFG Sbjct: 258 IIRHGTTEQRDLIGTLLAELTFDAPRRLGLMHGDAHPGNFML---LPDGRMGIIDFG 311 >5H12-A nrPDB Length = 775 Score = 32.2 bits (72), Expect = 0.44, Method: Composition-based stats. Identities = 18/118 (15%), Positives = 44/118 (37%), Gaps = 16/118 (13%) Query: 4 NSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDY 63 ++ G +P P + + + A+ P ++ F+V+ KK + D Sbjct: 541 DTDGLYATIPGAKPEEIKKKALEFVDYINAKLPGLLELEYEGFYVRGFFVTKKKYALIDE 600 Query: 64 KVTSQVLGLG--------------INGKVLQIFNKRTQEKFALKMLQDCPKARREVEL 107 + +++ G KVL+ K + A+K++++ + + E+ Sbjct: 601 E--GKIITRGLEIVRRDWSEIAKETQAKVLEAILKHGNVEEAVKIVKEVTEKLSKYEI 656 >2J89-A nrPDB Length = 261 Score = 31.4 bits (70), Expect = 0.63, Method: Composition-based stats. Identities = 13/37 (35%), Positives = 16/37 (43%) Query: 10 PPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQF 46 + F +P P P +P P P P QQF QF Sbjct: 63 SKLGFGTRSPDPSTMDPTIPQGPDDDLPAPGQQFAQF 99 >6DFL-A nrPDB Length = 259 Score = 31.4 bits (70), Expect = 0.70, Method: Composition-based stats. Identities = 12/63 (19%), Positives = 24/63 (38%), Gaps = 1/63 (1%) Query: 125 ENLYAGRKCLLIVME-CLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIA 183 R+ IV E +L QD ++ R +++++ + +H + Sbjct: 101 RGSDPARQHSFIVTEELAPTVDLEVFSQDWRERPPPPRLKRALVEAVARMVGDMHRAGVN 160 Query: 184 HRD 186 HRD Sbjct: 161 HRD 163 >4UUD-B nrPDB Length = 864 Score = 31.0 bits (69), Expect = 0.94, Method: Composition-based stats. Identities = 16/41 (39%), Positives = 21/41 (51%), Gaps = 1/41 (2%) Query: 7 GQSPPVPF-PAPAPPPQPPTPALPHPPAQPPPPPPQQFPQF 46 G +PPVP P +P P P P +P P + PP P + Q Sbjct: 810 GGAPPVPSRPGASPDPFGPPPQVPSRPNRAPPGVPSRSGQA 850 >4GYG-A nrPDB Length = 397 Score = 30.7 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 27/180 (15%), Positives = 60/180 (33%), Gaps = 37/180 (20%) Query: 56 KNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHW------ 109 A D Y V S+ +G+G ++ + +++ ++K LK+ + + R V+ + Sbjct: 90 HAARKDVYSVGSR-IGVGKESDIMIVADEKGKQKV-LKIHRLGRISFRTVKANRDYLRNR 147 Query: 110 ---------RASQCPHIVRIVDVYENLYAGRKCLL-----IVMECLDGGELFSRIQDRGD 155 R + + +YE + + + IVM +D + Sbjct: 148 STGSWMYLSRLAAIKEFAFMKALYEEGFPVPEPIAQSRHTIVMSLVDALPMRQVSSVPDP 207 Query: 156 QAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILK-------LTDF 208 + + I++ L + H D N+L ++ + DF Sbjct: 208 ASLYADLIALILR--------LAKHGLIHGDFNEFNILIREEKDAEDPSSITLTPIIIDF 259 >5MG3-F nrPDB Length = 323 Score = 30.7 bits (68), Expect = 1.2, Method: Composition-based stats. Identities = 10/33 (30%), Positives = 19/33 (57%), Gaps = 4/33 (12%) Query: 64 KVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ 96 + QVLG +VL++ N+ T + A+K ++ Sbjct: 104 ETGGQVLGS----QVLKVINESTNQNAAVKRIE 132 >4N78-D nrPDB Length = 559 Score = 30.3 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 21/69 (30%), Positives = 24/69 (34%), Gaps = 4/69 (5%) Query: 9 SPPVPFPAPAPPPQP--PTPALPHPPAQP--PPPPPQQFPQFHVKSGLQIKKNAIIDDYK 64 S PV A A PP PTP+ P P PP PP Q I D Sbjct: 440 SSPVTVTALAHPPSGLHPTPSTAPGPHVPLMPPSPPSQVIPASEPKRHPSTLPVISDARS 499 Query: 65 VTSQVLGLG 73 V + + G Sbjct: 500 VLLEAIRKG 508 >4DDG-A nrPDB Length = 399 Score = 29.9 bits (66), Expect = 2.2, Method: Composition-based stats. Identities = 11/48 (22%), Positives = 19/48 (39%), Gaps = 8/48 (16%) Query: 98 CPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGE 145 ++EVE + S HI+ + + I +E +D GE Sbjct: 329 KEFCQQEVEPMCKESDHIHIIALAQAL--------SVSIQVEYMDRGE 368 >1P4X-A nrPDB Length = 250 Score = 29.9 bits (66), Expect = 2.2, Method: Composition-based stats. Identities = 11/61 (18%), Positives = 28/61 (45%), Gaps = 2/61 (3%) Query: 79 LQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVM 138 ++ N ++ + +K + + R++ +H +Q H +++ L A + L +V Sbjct: 192 VRALNNLKKQGYLIK--ERSTEDERKILIHMDDAQQDHAEQLLAQVNQLLADKDHLHLVF 249 Query: 139 E 139 E Sbjct: 250 E 250 >3VON-A nrPDB Length = 228 Score = 29.5 bits (65), Expect = 2.4, Method: Composition-based stats. Identities = 11/48 (22%), Positives = 19/48 (39%), Gaps = 8/48 (16%) Query: 98 CPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGE 145 ++EVE + S HI+ + + I +E +D GE Sbjct: 158 KEFCQQEVEPMCKESDHIHIIALAQAL--------SVSIQVEYMDRGE 197 >6FF4-Y nrPDB Length = 904 Score = 29.5 bits (65), Expect = 2.5, Method: Composition-based stats. Identities = 11/40 (27%), Positives = 17/40 (42%) Query: 10 PPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVK 49 PP +P+PPP+ P P + P ++ P K Sbjct: 620 PPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSK 659 Score = 29.5 bits (65), Expect = 2.8, Method: Composition-based stats. Identities = 13/33 (39%), Positives = 19/33 (57%), Gaps = 3/33 (9%) Query: 16 APAPPPQPPTPALPHPP---AQPPPPPPQQFPQ 45 +P+PPP+ T + P PP A P PPP ++ Sbjct: 605 SPSPPPKRRTASPPPPPKRRASPSPPPKRRVSH 637 >6AHD-v nrPDB Length = 464 Score = 29.5 bits (65), Expect = 2.5, Method: Composition-based stats. Identities = 15/41 (36%), Positives = 17/41 (41%), Gaps = 1/41 (2%) Query: 7 GQSPPVPFP-APAPPPQPPTPALPHPPAQPPPPPPQQFPQF 46 G PP P PAP PP P + P + PP P P Sbjct: 300 GVHPPAPGVHPPAPGVHPPAPGVHPPTSGVHPPAPGVHPPA 340 Score = 29.1 bits (64), Expect = 3.3, Method: Composition-based stats. Identities = 15/35 (42%), Positives = 16/35 (45%), Gaps = 2/35 (5%) Query: 7 GQSPPVPFP-APAPPPQPPTPAL-PHPPAQPPPPP 39 G PP P PAP PPT + P P PP P Sbjct: 307 GVHPPAPGVHPPAPGVHPPTSGVHPPAPGVHPPAP 341 Score = 28.7 bits (63), Expect = 4.4, Method: Composition-based stats. Identities = 12/31 (38%), Positives = 13/31 (41%), Gaps = 1/31 (3%) Query: 10 PPVPFPAPAPPPQPPTPAL-PHPPAQPPPPP 39 P PAP PP P + P P PP P Sbjct: 325 PTSGVHPPAPGVHPPAPGVHPPAPGVHPPAP 355 >4N78-F nrPDB Length = 514 Score = 29.5 bits (65), Expect = 2.6, Method: Composition-based stats. Identities = 17/55 (30%), Positives = 18/55 (32%), Gaps = 4/55 (7%) Query: 9 SPPVPFPAPA----PPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAI 59 SPP FPAPA PP P T A P P P P + Sbjct: 278 SPPSVFPAPAGSAGTPPLPATSASAPAPLVPATVPSSTAPDAAAGGAQTLADGFT 332 >5HD1-1D nrPDB Length = 276 Score = 29.5 bits (65), Expect = 2.9, Method: Composition-based stats. Identities = 13/62 (20%), Positives = 19/62 (30%), Gaps = 4/62 (6%) Query: 7 GQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVT 66 G+ P V A P P P PP P GL+ +K + Sbjct: 216 GRRPHVRGAAMNPVDHPHGGGEGRAPRGRPPASPWG----WQTKGLKTRKRRKPSSRFII 271 Query: 67 SQ 68 ++ Sbjct: 272 AR 273 >5T7C-A nrPDB Length = 193 Score = 29.5 bits (65), Expect = 2.9, Method: Composition-based stats. Identities = 10/57 (17%), Positives = 21/57 (36%) Query: 339 SRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEA 395 S +L+ + ++ V M + KI + D +N L + R ++ Sbjct: 119 SEMLEIVQAIYKMVSSVMKMPEDESTPEKRTDKIFRQMDTNNDGKLSLEEFIRGAKS 175 >4CE4-l nrPDB Length = 166 Score = 29.5 bits (65), Expect = 3.0, Method: Composition-based stats. Identities = 12/40 (30%), Positives = 15/40 (37%) Query: 10 PPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVK 49 PP P P PTP+ PP P P P + + Sbjct: 53 PPASIPRPPKHEHYPTPSGWQPPRDPAPSLPYFVRRSRMH 92 >5H2T-A nrPDB Length = 601 Score = 28.7 bits (63), Expect = 4.9, Method: Composition-based stats. Identities = 17/102 (16%), Positives = 39/102 (38%), Gaps = 15/102 (14%) Query: 263 FYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKML---IRNLLKTEPTQRM--TIT 317 + + + P ++ +R G Y+ +++++ E L + L E +R I Sbjct: 59 WLGIDCIWLLPIYQSPLRDGGYDIS--DYTKILPEFGDLGDFVE--LVDEAHRRGIRVIA 114 Query: 318 EFM------NHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVK 353 + + HPW S P P + + +++ D + Sbjct: 115 DLVMNHTSDQHPWFQASRTDPDGPYGDFYMWSDTDDKYPDAR 156 >2G64-A nrPDB Length = 140 Score = 28.7 bits (63), Expect = 5.0, Method: Composition-based stats. Identities = 8/45 (17%), Positives = 21/45 (46%) Query: 94 MLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVM 138 M+ D K ++E+ L ++ + V+ ++ + + + I M Sbjct: 64 MVYDLAKLKKEMSLVLDTVDHRNLDKDVEFFKTTVSTSENVAIYM 108 >5M6C-E nrPDB Length = 193 Score = 28.7 bits (63), Expect = 5.2, Method: Composition-based stats. Identities = 9/56 (16%), Positives = 20/56 (35%) Query: 340 RVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEA 395 +L+ + ++ V M + KI + D +N L + R ++ Sbjct: 120 EMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFRQMDTNNDGKLSLEEFIRGAKS 175 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.148 0.439 Lambda K H 0.267 0.0453 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,924,595 Number of Sequences: 36641 Number of extensions: 734235 Number of successful extensions: 8988 Number of sequences better than 10.0: 563 Number of HSP's better than 10.0 without gapping: 920 Number of HSP's successfully gapped in prelim test: 177 Number of HSP's that attempted gapping in prelim test: 3121 Number of HSP's gapped (non-prelim): 2102 length of query: 400 length of database: 10,336,785 effective HSP length: 99 effective length of query: 301 effective length of database: 6,709,326 effective search space: 2019507126 effective search space used: 2019507126 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 61 (28.0 bits)