BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P48643 (541 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5UYZ-A nrPDB 1107 0.0 4V8R-AE nrPDB 693 0.0 4XCI-A nrPDB 385 e-107 3RUW-A nrPDB 384 e-107 4XCG-B nrPDB 383 e-106 1Q3S-A nrPDB 378 e-105 3J1C-A nrPDB 376 e-104 3IYF-A nrPDB 374 e-104 3J1E-A nrPDB 374 e-104 1A6E-A nrPDB 363 e-101 1A6D-B nrPDB 358 3e-99 4B2T-D nrPDB 346 1e-95 5GW4-d nrPDB 327 6e-90 3AQ1-B nrPDB 325 3e-89 4B2T-G nrPDB 302 3e-82 5GW5-g nrPDB 287 8e-78 4B2T-A nrPDB 264 7e-71 4V8R-AB nrPDB 259 3e-69 5GW4-h nrPDB 257 7e-69 4B2T-H nrPDB 250 9e-67 4B2T-B nrPDB 250 9e-67 4B2T-Z nrPDB 236 2e-62 4V94-A nrPDB 225 3e-59 4B2T-Q nrPDB 209 2e-54 5GW5-z nrPDB 201 7e-52 4V8R-AG nrPDB 198 4e-51 5GW5-q nrPDB 196 2e-50 5X9V-A nrPDB 176 2e-44 1E0R-B nrPDB 102 5e-22 1ASS-A nrPDB 100 1e-21 1GN1-A nrPDB 95 7e-20 4V4O-A nrPDB 68 1e-11 4AAR-A nrPDB 58 1e-08 4PJ1-A nrPDB 55 9e-08 1SJP-A nrPDB 54 2e-07 5DA8-A nrPDB 50 3e-06 1IOK-A nrPDB 48 1e-05 5CDI-A nrPDB 44 1e-04 3FIJ-A nrPDB 32 0.51 1Q1R-A nrPDB 32 1.0 3EXA-A nrPDB 31 1.2 4FYP-A nrPDB 30 3.0 2VLD-A nrPDB 30 3.7 1RLU-A nrPDB 29 4.7 4RUN-A nrPDB 29 5.7 3JVD-A nrPDB 29 6.3 4BT6-A nrPDB 28 8.3 >5UYZ-A nrPDB Length = 541 Score = 1107 bits (2862), Expect = 0.0, Method: Compositional matrix adjust. Identities = 540/541 (99%), Positives = 540/541 (99%) Query: 1 MASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKM 60 MASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKM Sbjct: 1 MASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKM 60 Query: 61 MVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEA 120 MVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEA Sbjct: 61 MVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEA 120 Query: 121 EQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNS 180 EQLLDRGIHPIRIADGYEQAARVAIE LDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNS Sbjct: 121 EQLLDRGIHPIRIADGYEQAARVAIERLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNS 180 Query: 181 CHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMP 240 CHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMP Sbjct: 181 CHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMP 240 Query: 241 KKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLA 300 KKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLA Sbjct: 241 KKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLA 300 Query: 301 ICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQ 360 ICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQ Sbjct: 301 ICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQ 360 Query: 361 EISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVY 420 EISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVY Sbjct: 361 EISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVY 420 Query: 421 GGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRAR 480 GGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRAR Sbjct: 421 GGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRAR 480 Query: 481 QVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESE 540 QVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESE Sbjct: 481 QVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESE 540 Query: 541 E 541 E Sbjct: 541 E 541 >4V8R-AE nrPDB Length = 562 Score = 693 bits (1788), Expect = 0.0, Method: Compositional matrix adjust. Identities = 326/546 (59%), Positives = 442/546 (80%), Gaps = 8/546 (1%) Query: 3 SMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMV 62 S +A DE GRPF+I+KDQ K R GLEA KSHI+AA++VA+ ++TSLGP GLDK+++ Sbjct: 16 SNAIVAQDEMGRPFIIVKDQGNKKRQHGLEAKKSHILAARSVASIIKTSLGPRGLDKILI 75 Query: 63 DKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQ 122 DG++T+TNDGATILS M++D++IAKL+V+LSKSQDDEIGDGTTGVVVLA ALL++A + Sbjct: 76 SPDGEITITNDGATILSQMELDNEIAKLLVQLSKSQDDEIGDGTTGVVVLASALLDQALE 135 Query: 123 LLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKD--TEPLIQTAKTTLGSKVVNS 180 L+ +GIHPI+IA+G+++AA++AI L++ D + + + L++ AKT+LGSK+V+ Sbjct: 136 LIQKGIHPIKIANGFDEAAKLAISKLEETCDDISASNDELFRDFLLRAAKTSLGSKIVSK 195 Query: 181 CHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMP 240 H + AE+AV AV+ V D +R+DVDF+LIK++G+VGG + D+KLI GVI+DKDFSHPQMP Sbjct: 196 DHDRFAEMAVEAVINVMDKDRKDVDFDLIKMQGRVGGSISDSKLINGVILDKDFSHPQMP 255 Query: 241 KKV------EDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKE 294 K V + K+AILTCPFEPPKPKTKHKLD++SVE+Y+ LQ YE++KF+EMI +K+ Sbjct: 256 KCVLPKEGSDGVKLAILTCPFEPPKPKTKHKLDISSVEEYQKLQTYEQDKFKEMIDDVKK 315 Query: 295 TGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLG 354 GA++ ICQWGFDDEANHLLLQN+LPAVRWVGG E+E IAI+T GRIVPRF +L+ +KLG Sbjct: 316 AGADVVICQWGFDDEANHLLLQNDLPAVRWVGGQELEHIAISTNGRIVPRFQDLSKDKLG 375 Query: 355 FAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIR 414 + E FGTTKD+ML+IEQ K ++ VT F+RG NKMI++EA+R+LHD+LCV+RNL++ Sbjct: 376 TCSRIYEQEFGTTKDRMLIIEQSKETKTVTCFVRGSNKMIVDEAERALHDSLCVVRNLVK 435 Query: 415 DNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTM 474 D+RVVYGGGAAE++ +LAVS+EADK ++QYA R FA AL+ IPM L+ENSG++PI T+ Sbjct: 436 DSRVVYGGGAAEVTMSLAVSEEADKQRGIDQYAFRGFAQALDTIPMTLAENSGLDPIGTL 495 Query: 475 TEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIR 534 + ++++Q+KE +G+DCL G+NDMK+ V++ IGKKQQI LATQ+ RMILKID++ Sbjct: 496 STLKSKQLKEKISNIGVDCLGYGSNDMKELFVVDPFIGKKQQILLATQLCRMILKIDNVI 555 Query: 535 KPGESE 540 G+ E Sbjct: 556 ISGKDE 561 >4XCI-A nrPDB Length = 559 Score = 385 bits (988), Expect = e-107, Method: Compositional matrix adjust. Identities = 221/531 (41%), Positives = 335/531 (63%), Gaps = 19/531 (3%) Query: 15 PFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDG 74 P L++K+ SR G +AL+++I+AAK +A +R+SLGP GLDKM++D GDVT+TNDG Sbjct: 4 PVLLLKEG--TSRTTGRDALRNNILAAKTLAEMLRSSLGPKGLDKMLIDSFGDVTITNDG 61 Query: 75 ATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIA 134 ATI+ M++ H AKL+VE +K+QD E+GDGTT VVLAGALLE+AE LLD+ IHP I Sbjct: 62 ATIVKDMEIQHPAAKLLVEAAKAQDAEVGDGTTSAVVLAGALLEKAESLLDQNIHPTIII 121 Query: 135 DGYEQAARVAIEHLDKISDSVLVDIKDT------EPLIQTAKTTLGSKVV--NSCHRQMA 186 +GY++A A+E L ++ +DIKD + L + A TTL SK + + ++ Sbjct: 122 EGYKKAYNKALELLPQLGTR--IDIKDLNSSVARDTLRKIAFTTLASKFIAEGAELNKII 179 Query: 187 EIAVNAVLTVAD---MERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKV 243 ++ ++A++ VA+ +V +LIK++ K GG +ED+ L+KG+++DK+ HP MP++V Sbjct: 180 DMVIDAIVNVAEPLPNGGYNVSLDLIKIDKKKGGSIEDSVLVKGLVLDKEVVHPGMPRRV 239 Query: 244 EDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQ 303 AKIA+L E KP+ K+ +TS E KA E + ++M+ ++ GAN+ ICQ Sbjct: 240 TKAKIAVLDAALEVEKPEISAKISITSPEQIKAFLDEESKYLKDMVDKLASIGANVVICQ 299 Query: 304 WGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEIS 363 G DD A H L + + AVR V +IE + A G RI+ + T E LG+A LV+E Sbjct: 300 KGIDDIAQHFLAKKGILAVRRVKRSDIEKLEKALGARIISSIKDATPEDLGYAELVEERR 359 Query: 364 FGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGG 423 G DKM+ IE KN +AV I +RG N M ++EA+RS++DAL +RN++ + ++ GGG Sbjct: 360 VGN--DKMVFIEGAKNLKAVNILLRGSNDMALDEAERSINDALHALRNILLEPVILPGGG 417 Query: 424 AAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVK 483 A E+ A+ + + A EQ A+ AFADALE IP+ L+E +G+ I ++ ++RAR K Sbjct: 418 AIELELAMKLREYARSVGGKEQLAIEAFADALEEIPLILAETAGLEAISSLMDLRARHAK 477 Query: 484 EMNPALGIDCL-HKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDI 533 ++ G+D + K +D+ ++IE + K Q + AT+ ILKIDD+ Sbjct: 478 GLSNT-GVDVIGGKIVDDVYALNIIEPIRVKSQVLKSATEAATAILKIDDL 527 >3RUW-A nrPDB Length = 543 Score = 384 bits (986), Expect = e-107, Method: Compositional matrix adjust. Identities = 211/507 (41%), Positives = 317/507 (62%), Gaps = 5/507 (0%) Query: 27 RLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQ 86 R MG +A + +I+A + +A T+R++LGP G+DKM+VD GDV VTNDG TIL M V+H Sbjct: 14 RYMGRDAQRMNILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVVTNDGVTILREMSVEHP 73 Query: 87 IAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIE 146 AK+++E++K+Q+ E+GDGTT VV+AG LL +AE+LLD+ +HP + GY+ AA+ A E Sbjct: 74 AAKMLIEVAKTQEKEVGDGTTTAVVVAGELLRKAEELLDQNVHPTIVVKGYQAAAQKAQE 133 Query: 147 HLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDF 206 L I + V +D E L + A T++ K ++AEI V AV V D E + VD Sbjct: 134 LLKTI--ACEVGAQDKEILTKIAMTSITGKGAEKAKEKLAEIIVEAVSAVVDDEGK-VDK 190 Query: 207 ELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKL 266 +LIK+E K G ++DT+LIKGV+VDK+ QMPKKV DAKIA+L C E + +T ++ Sbjct: 191 DLIKIEKKSGASIDDTELIKGVLVDKERVSAQMPKKVTDAKIALLNCAIEIKETETDAEI 250 Query: 267 DVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVG 326 +T + E++ ++M+ +IK +GAN+ CQ G DD A H L + + A R V Sbjct: 251 RITDPAKLMEFIEQEEKMLKDMVAEIKASGANVLFCQKGIDDLAQHYLAKEGIVAARRVK 310 Query: 327 GPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIF 386 ++E +A ATG ++ + L+A+ LG AGLV+E + D M+ +E+CK+ +AVT+ Sbjct: 311 KSDMEKLAKATGANVIAAIAALSAQDLGDAGLVEERKI--SGDSMIFVEECKHPKAVTML 368 Query: 387 IRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQY 446 IRG + +IEE R++ DA+ V+ I D R+V GGG+ E+ ++ + + A+ EQ Sbjct: 369 IRGTTEHVIEEVARAVDDAVGVVGCTIEDGRIVSGGGSTEVELSMKLREYAEGISGREQL 428 Query: 447 AMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHV 506 A+RAFADALEVIP L+EN+G++ I+ + +VRA N G++ DM + V Sbjct: 429 AVRAFADALEVIPRTLAENAGLDAIEILVKVRAAHASNGNKCAGLNVFTGAVEDMCENGV 488 Query: 507 IETLIGKKQQISLATQMVRMILKIDDI 533 +E L K Q I A + M+L+IDD+ Sbjct: 489 VEPLRVKTQAIQSAAESTEMLLRIDDV 515 >4XCG-B nrPDB Length = 557 Score = 383 bits (984), Expect = e-106, Method: Compositional matrix adjust. Identities = 208/538 (38%), Positives = 332/538 (61%), Gaps = 8/538 (1%) Query: 3 SMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMV 62 + T+A G P +I+K+ SR G EAL+++I A KA+ ++++ GP G+DKM+V Sbjct: 5 ATATVATTPEGIPVIILKEGS--SRTYGKEALRANIAAVKAIEEALKSTYGPRGMDKMLV 62 Query: 63 DKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQ 122 D GD+T+TNDGATIL MD+ H KL+V+++K QD+E DGT V+LAG L ++AE Sbjct: 63 DSLGDITITNDGATILDKMDLQHPTGKLLVQIAKGQDEETADGTKTAVILAGELAKKAED 122 Query: 123 LLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCH 182 LL + IHP I GY++A +A++ + +I+ V ++ DT+ L + A T+LGSK V Sbjct: 123 LLYKEIHPTIIVSGYKKAEEIALKTIQEIAQPVTIN--DTDVLRKVALTSLGSKAVAGAR 180 Query: 183 RQMAEIAVNAVLTVADM--ERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMP 240 +A++ V AV VA++ ++ VD + +++ K GG + DT+L+ G++VDK+ HP MP Sbjct: 181 EYLADLVVKAVAQVAELRGDKWYVDLDNVQIVKKHGGSVNDTQLVYGIVVDKEVVHPGMP 240 Query: 241 KKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLA 300 K++E+AKIA+L E KP+ ++ + + E+ +E + +I TGAN+ Sbjct: 241 KRIENAKIALLDASLEVEKPELDAEIRINDPTQMHKFLEEEENILKEKVDKIAATGANVV 300 Query: 301 ICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQ 360 ICQ G D+ A H L + + AVR ++E +A ATGGR++ ELT++ LG+A LV+ Sbjct: 301 ICQKGIDEVAQHYLAKKGILAVRRAKKSDLEKLARATGGRVISNIDELTSQDLGYAALVE 360 Query: 361 EISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVY 420 E G +DKM+ +E KN ++V+I IRGG + +++E +R+L DAL + ++IRD R V Sbjct: 361 ERKVG--EDKMVFVEGAKNPKSVSILIRGGLERVVDETERALRDALGTVADVIRDGRAVA 418 Query: 421 GGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRAR 480 GGGA EI A + + A + EQ A+ A+A+A+E + M L+EN+G++PI + ++R+ Sbjct: 419 GGGAVEIEIAKRLRKYAPQVGGKEQLAIEAYANAIEGLIMILAENAGLDPIDKLMQLRSL 478 Query: 481 QVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGE 538 E N G++ DM + VIE + K + AT+ V ++L+IDDI G+ Sbjct: 479 HENETNKWYGLNLFTGNPEDMWKLGVIEPALVKMNAVKAATEAVTLVLRIDDIVAAGK 536 >1Q3S-A nrPDB Length = 548 Score = 378 bits (970), Expect = e-105, Method: Compositional matrix adjust. Identities = 216/525 (41%), Positives = 334/525 (63%), Gaps = 13/525 (2%) Query: 13 GRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTN 72 G+P +I+ + + R +G +A + +I+AA+ +A T+RT+LGP G+DKM+VD GD+ VTN Sbjct: 6 GQPVVILPEGTQ--RYVGRDAQRLNILAARIIAETVRTTLGPKGMDKMLVDSLGDIVVTN 63 Query: 73 DGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIR 132 D ATIL +D+ H AK+MVE++K+QD E GDGTT VV+AG LL +AE+LLD+ IHP Sbjct: 64 DCATILDKIDLQHPAAKMMVEVAKTQDKEAGDGTTTAVVIAGELLRKAEELLDQNIHPSI 123 Query: 133 IADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNA 192 I GY AA A E LD+I ++ VD D E L++ A T++ K S +A++AV A Sbjct: 124 IIKGYALAAEKAQEILDEI--AIRVDPDDEETLLKIAATSITGKNAESHKELLAKLAVEA 181 Query: 193 VLTVADMERRD----VDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKI 248 V VA E++D VD + IK E K G +E+++L++GV++DK+ HP+MPK+VE+AKI Sbjct: 182 VKQVA--EKKDGKYVVDLDNIKFEKKAGEGVEESELVRGVVIDKEVVHPRMPKRVENAKI 239 Query: 249 AILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDD 308 A++ E K +T K+++TS + + + E++ ++M+ I +TGAN+ Q G DD Sbjct: 240 ALINEALEVKKTETDAKINITSPDQLMSFLEQEEKMLKDMVDHIAQTGANVVFVQKGIDD 299 Query: 309 EANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTK 368 A H L + + AVR V ++E +A ATG +IV +LT E LG+A +V+E Sbjct: 300 LAQHYLAKYGIMAVRRVKKSDMEKLAKATGAKIVTNVKDLTPEDLGYAEVVEERKLAG-- 357 Query: 369 DKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEIS 428 + M+ +E CKN +AVTI IRGG + +I+E +R+L DA+ V+++++ D V+ GGA EI Sbjct: 358 ENMIFVEGCKNPKAVTILIRGGTEHVIDEVERALEDAVKVVKDVMEDGAVLPAGGAPEIE 417 Query: 429 CALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPA 488 A+ + + A + E A+ FADAL++IP L+EN+G++ ++ + +V + K Sbjct: 418 LAIRLDEYAKQVGGKEALAIENFADALKIIPKTLAENAGLDTVEMLVKVISEH-KNRGLG 476 Query: 489 LGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDI 533 +GID DM ++ +IE L KKQ I A++ MIL+IDD+ Sbjct: 477 IGIDVFEGKPADMLEKGIIEPLRVKKQAIKSASEAAIMILRIDDV 521 >3J1C-A nrPDB Length = 563 Score = 376 bits (965), Expect = e-104, Method: Compositional matrix adjust. Identities = 215/533 (40%), Positives = 331/533 (62%), Gaps = 19/533 (3%) Query: 13 GRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTN 72 G P L+ K+ SR G +ALK++I+AA+ +A +R+SLGP GLDKM++D GDVT+TN Sbjct: 4 GVPVLLFKEG--TSRNSGRDALKNNILAARTLAEMLRSSLGPKGLDKMLIDSFGDVTITN 61 Query: 73 DGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIR 132 DGATI+ M++ H AKL+VE +K+QD E+GDGTT VVLAG LE+AE L+D+ IHP Sbjct: 62 DGATIVKEMEIQHPAAKLLVEAAKAQDSEVGDGTTSAVVLAGLFLEKAESLVDQNIHPTI 121 Query: 133 IADGYEQAARVAIEHLDKISDSVLVDIKDT------EPLIQTAKTTLGSKVVNSCH--RQ 184 I +G+++A ++E L +++ VD+ D + L + TT+ SK + + Sbjct: 122 IIEGFKKAFNKSLELLPQLATK--VDVSDLNSATARDALKKIVYTTMSSKFMAEGEELNK 179 Query: 185 MAEIAVNAVLTVADM---ERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPK 241 + +I ++AV TVA+ +V +LIK++ K GG +ED++LI+G+++DK+ H MP+ Sbjct: 180 IMDIVIDAVTTVAEPLPDGGYNVSLDLIKIDKKKGGTIEDSQLIRGIVLDKEVVHAGMPR 239 Query: 242 KVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAI 301 +VE AKIA+L E KP+ K+ +TS + KA E + ++M+ ++ GAN+ I Sbjct: 240 RVEKAKIAVLDASLEVEKPEISAKISITSPDQIKAFLDEEAKYLKDMVDKLASIGANVVI 299 Query: 302 CQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQE 361 CQ G DD A H L + + AVR V +IE + A G RI+ + T E LG+A LV+E Sbjct: 300 CQKGIDDIAQHFLAKRGILAVRRVKRSDIEKLEKALGARIISSIKDATPEDLGYAELVEE 359 Query: 362 ISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYG 421 G DKM+ IE KN +AV I +RG N M ++EA+RS++DAL +RN++ + +V G Sbjct: 360 RKVGN--DKMVFIEGAKNPKAVNILLRGSNDMALDEAERSINDALYSLRNILMEPYIVPG 417 Query: 422 GGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQ 481 GGA E+ + + + A EQ A+ A+ADALE IPM L+E +G+ PI + ++RAR Sbjct: 418 GGAIELELSARLREYARSVGGKEQLAIEAYADALEEIPMILAETAGLEPISALMDLRARH 477 Query: 482 VKEMNPALGIDCLH-KGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDI 533 K + G+D ++ K +D+ +V+E + +Q + AT+ I+KIDD+ Sbjct: 478 AKGLTNC-GVDVINGKIIDDIYSINVVEPIRVTRQVLKSATEAATSIMKIDDL 529 >3IYF-A nrPDB Length = 521 Score = 374 bits (960), Expect = e-104, Method: Compositional matrix adjust. Identities = 209/507 (41%), Positives = 310/507 (61%), Gaps = 27/507 (5%) Query: 27 RLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQ 86 R MG +A + +I+A + +A T+R++LGP G+DKM+VD GDV VTNDG TIL M V+H Sbjct: 14 RYMGRDAQRMNILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVVTNDGVTILREMSVEHP 73 Query: 87 IAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIE 146 AK+++E++K+Q+ E+GDGTT VV+AG LL +AE+LLD+ +HP + GY+ AA+ A E Sbjct: 74 AAKMLIEVAKTQEKEVGDGTTTAVVVAGELLRKAEELLDQNVHPTIVVKGYQAAAQKAQE 133 Query: 147 HLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDF 206 L I + V +D E L + A T++ K ++AEI V AV V D E + VD Sbjct: 134 LLKTI--ACEVGAQDKEILTKIAMTSITGKGAEKAKEKLAEIIVEAVSAVVDDEGK-VDK 190 Query: 207 ELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKL 266 +LIK+E K G ++DT+LIKGV+VDK+ QMPKKV DAKIA+L C Sbjct: 191 DLIKIEKKSGASIDDTELIKGVLVDKERVSAQMPKKVTDAKIALLNC------------- 237 Query: 267 DVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVG 326 A+++ E ++M+ +IK +GAN+ CQ G DD A H L + + A R V Sbjct: 238 ---------AIEETASEMLKDMVAEIKASGANVLFCQKGIDDLAQHYLAKEGIVAARRVK 288 Query: 327 GPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIF 386 ++E +A ATG ++ +L+A+ LG AGLV+E + D M+ +E+CK+ +AVT+ Sbjct: 289 KSDMEKLAKATGANVITNIKDLSAQDLGDAGLVEERKI--SGDSMIFVEECKHPKAVTML 346 Query: 387 IRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQY 446 IRG + +IEE R++ DA+ V+ I D R+V GGG+ E+ ++ + + A+ EQ Sbjct: 347 IRGTTEHVIEEVARAVDDAVGVVGCTIEDGRIVSGGGSTEVELSMKLREYAEGISGREQL 406 Query: 447 AMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHV 506 A+RAFADALEVIP L+EN+G++ I+ + +VRA N G++ DM + V Sbjct: 407 AVRAFADALEVIPRTLAENAGLDAIEILVKVRAAHASNGNKCAGLNVFTGAVEDMCENGV 466 Query: 507 IETLIGKKQQISLATQMVRMILKIDDI 533 +E L K Q I A + M+L+IDD+ Sbjct: 467 VEPLRVKTQAIQSAAESTEMLLRIDDV 493 >3J1E-A nrPDB Length = 553 Score = 374 bits (959), Expect = e-104, Method: Compositional matrix adjust. Identities = 209/543 (38%), Positives = 333/543 (61%), Gaps = 14/543 (2%) Query: 1 MASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKM 60 MAS T+A G P +I+K+ SR G EA++++I A KAV ++++ GP G+DKM Sbjct: 1 MASTATVATTPEGIPVIILKEG--SSRTYGKEAVRANIAAVKAVEEALKSTYGPRGMDKM 58 Query: 61 MVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEA 120 +VD GD+T+TNDGATIL MD+ H AKL+V+++K QD+E DGT V+ +G L+++A Sbjct: 59 LVDSLGDITITNDGATILDKMDLQHPAAKLLVQIAKGQDEETADGTKTAVIFSGELVKKA 118 Query: 121 EQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNS 180 E LL + +HP I GY++A VA++ + +++ + V I DT+ L + A T+L SK V Sbjct: 119 EDLLYKDVHPTIIISGYKKAEEVALQTIQELAQT--VSINDTDLLRKIAMTSLSSKAVAG 176 Query: 181 CHRQMAEIAVNAVLTVADM--ERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQ 238 +A+I V AV VA++ ++ VD + I++ K GG + DT+L+ G++VDK+ HP Sbjct: 177 AREYIADIVVKAVTQVAELRGDKWYVDLDNIQIVKKAGGSINDTQLVYGIVVDKEVVHPG 236 Query: 239 MPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKY---EKEKFEEMIQQIKET 295 MPK++E+AKIA++ E KP+ ++ + D +QK+ E+ +E + +I T Sbjct: 237 MPKRLENAKIALIDASLEVEKPELDAEI---RINDPTQMQKFLDEEENLIKEKVDKILAT 293 Query: 296 GANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGF 355 GAN+ ICQ G D+ A L + + AVR ++E +A ATGGR+V E++ + LG+ Sbjct: 294 GANVIICQKGIDEVAQSYLAKKGVLAVRRAKKSDLEKLARATGGRVVSNIDEISEQDLGY 353 Query: 356 AGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRD 415 A L++E G +DKM+ +E KN ++++I IRGG + +++E +R+L DAL + ++I+D Sbjct: 354 ASLIEERKVG--EDKMVFVEGAKNPKSISILIRGGLERLVDETERALRDALGTVADVIKD 411 Query: 416 NRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMT 475 R + GGGA EI A + + A + EQ A+ A+A+ALE + L EN+G +PI + Sbjct: 412 GRAIAGGGAVEIEIAKKLRKYAPQVGGKEQLAVEAYANALESLVSILIENAGFDPIDLLM 471 Query: 476 EVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRK 535 ++R+ E N GID DM Q+ VIE + K I AT+ ++L+IDD+ Sbjct: 472 KLRSTHENENNKWYGIDLYAGQPVDMWQKGVIEPALVKMNAIKAATEAATLVLRIDDVVS 531 Query: 536 PGE 538 G+ Sbjct: 532 AGK 534 >1A6E-A nrPDB Length = 545 Score = 363 bits (933), Expect = e-101, Method: Compositional matrix adjust. Identities = 208/523 (39%), Positives = 321/523 (61%), Gaps = 15/523 (2%) Query: 15 PFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDG 74 P L++K+ + R G A +++I AAKA+A+ +RT+LGP G+DKM+VD GD+ ++NDG Sbjct: 7 PILVLKEGTQ--REQGKNAQRNNIEAAKAIADAVRTTLGPKGMDKMLVDSIGDIIISNDG 64 Query: 75 ATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIA 134 ATIL MDV+H AK++VE+SK+QD +GDGTT VVL+G LL++AE LLD+G+HP I+ Sbjct: 65 ATILKEMDVEHPTAKMIVEVSKAQDTAVGDGTTTAVVLSGELLKQAETLLDQGVHPTVIS 124 Query: 135 DGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVL 194 +GY R+A+ KI D + D L + A T L K + +A++ V AV Sbjct: 125 NGY----RLAVNEARKIIDEIAEKSTDDATLRKIALTALSGKNTGLSNDFLADLVVKAVN 180 Query: 195 TVADMERRD----VDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAI 250 VA E RD VD IKV+ K GG + DT+ I G+++DK+ H +MP V++AKIA+ Sbjct: 181 AVA--EVRDGKTIVDTANIKVDKKNGGSVNDTQFISGIVIDKEKVHSKMPDVVKNAKIAL 238 Query: 251 LTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEA 310 + E K + + K+ ++ + E F++M+++IK++GAN+ +CQ G DD A Sbjct: 239 IDSALEIKKTEIEAKVQISDPSKIQDFLNQETNTFKQMVEKIKKSGANVVLCQKGIDDVA 298 Query: 311 NHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDK 370 H L + + AVR V ++E +A ATG +IV +LT LG A V+E G D+ Sbjct: 299 QHYLAKEGIYAVRRVKKSDMEKLAKATGAKIVTDLDDLTPSVLGEAETVEERKIG--DDR 356 Query: 371 MLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCA 430 M + CKN +AV+I IRGG ++ E +R+L+DA+ V+ D + ++GGGA E A Sbjct: 357 MTFVMGCKNPKAVSILIRGGTDHVVSEVERALNDAIRVVAITKEDGKFLWGGGAVEAELA 416 Query: 431 LAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALG 490 + +++ A+ EQ A+ AFA ALE+IP L+EN+G++PI T+ +++A K ++G Sbjct: 417 MRLAKYANSVGGREQLAIEAFAKALEIIPRTLAENAGIDPINTLIKLKADDEKG-RISVG 475 Query: 491 IDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDI 533 +D + G DMK + V++ L K + A ++ MIL+IDD+ Sbjct: 476 VDLDNNGVGDMKAKGVVDPLRVKTHALESAVEVATMILRIDDV 518 >1A6D-B nrPDB Length = 543 Score = 358 bits (920), Expect = 3e-99, Method: Compositional matrix adjust. Identities = 214/526 (40%), Positives = 323/526 (61%), Gaps = 15/526 (2%) Query: 13 GRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTN 72 G+P I+K+ + R G +A+K +I AA A++N++R+SLGP G+DKM+VD GD+ +TN Sbjct: 4 GQPIFILKEGTK--RESGKDAMKENIEAAIAISNSVRSSLGPRGMDKMLVDSLGDIVITN 61 Query: 73 DGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIR 132 DG TIL MDV+H AK+MVE+SK+QD +GDGTT V++AG LL++A+ L+++ +HP Sbjct: 62 DGVTILKEMDVEHPAAKMMVEVSKTQDSFVGDGTTTAVIIAGGLLQQAQGLINQNVHPTV 121 Query: 133 IADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNA 192 I++GY A+ A +D+IS + D K L++ A+T+L SK + ++AEI+ A Sbjct: 122 ISEGYRMASEEAKRVIDEISTKIGADEKAL--LLKMAQTSLNSKSASVAKDKLAEISYEA 179 Query: 193 VLTVADME--RRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAI 250 V +VA++ + VDF+ I+V K GG ++DT+LI G+IVDK+ HP MP V+DAKIA+ Sbjct: 180 VKSVAELRDGKYYVDFDNIQVVKKQGGAIDDTQLINGIIVDKEKVHPGMPDVVKDAKIAL 239 Query: 251 LTCPFEPPKPKTKHKLDVTSVEDYKALQKY---EKEKFEEMIQQIKETGANLAICQWGFD 307 L P E KP+ L +ED +QK+ E+ EM+ +IK GAN+ I Q G D Sbjct: 240 LDAPLEIKKPEFDTNL---RIEDPSMIQKFLAQEENMLREMVDKIKSVGANVVITQKGID 296 Query: 308 DEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTT 367 D A H L + + AVR V +++ +A ATG IV E+++ LG A V+++ G Sbjct: 297 DMAQHYLSRAGIYAVRRVKKSDMDKLAKATGASIVSTIDEISSSDLGTAERVEQVKVG-- 354 Query: 368 KDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEI 427 +D M + CKN +AV+I +RG + +++E +RS+ D+L V+ + + D GGGA Sbjct: 355 EDYMTFVTGCKNPKAVSILVRGETEHVVDEMERSITDSLHVVASALEDGAYAAGGGATAA 414 Query: 428 SCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNP 487 A + A K +Q A+ FADA+E IP AL+EN+G++PI + ++RA K N Sbjct: 415 EIAFRLRSYAQKIGGRQQLAIEKFADAIEEIPRALAENAGLDPIDILLKLRAEHAKG-NK 473 Query: 488 ALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDI 533 GI+ DM + VIE + KQ I AT+ MIL+IDD+ Sbjct: 474 TYGINVFTGEIEDMVKNGVIEPIRVGKQAIESATEAAIMILRIDDV 519 >4B2T-D nrPDB Length = 542 Score = 346 bits (888), Expect = 1e-95, Method: Compositional matrix adjust. Identities = 199/505 (39%), Positives = 313/505 (61%), Gaps = 12/505 (2%) Query: 36 SHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELS 95 S+I AAKAVA+ +RTSLGP G+DKM+ D GDVT+TNDGATIL M V H A+++VELS Sbjct: 39 SNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVELS 98 Query: 96 KSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSV 155 K+QD E GDGTT VV++AG+LL+ +LL +GIHP I++ +++A IE L +S V Sbjct: 99 KAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGIEILTDMSRPV 158 Query: 156 LVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVAD-MERRDVDFELIKVEGK 214 ++ D E L+ +A T+L SKVV+ ++ ++V+AV+ V D VD IK+ K Sbjct: 159 --ELSDRETLLNSAATSLNSKVVSQYSSLLSPMSVDAVMKVIDPATATSVDLRDIKIVKK 216 Query: 215 VGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDY 274 +GG ++D +L++G+++ + ++ + +VE AKI ++ PK +++ V+ Sbjct: 217 LGGTIDDCELVEGLVLTQKVANSGI-TRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYVQM 275 Query: 275 KALQKYEKEKFEEMIQQIKETGANLAICQW-----GFDDEANHLLLQNNLPAVRWVGGPE 329 + + E+ +++QIK+TG N+ + Q D A H L + + V+ + + Sbjct: 276 DRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMVVKDIERED 335 Query: 330 IELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKN-SRAVTIFIR 388 IE I G + V + TA+ LG A L +E+S + K++ I C + + VTI +R Sbjct: 336 IEFICKTIGTKPVAHVDQFTADMLGSAELAEEVSLNGS-GKLIKITGCASPGKTVTIVVR 394 Query: 389 GGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAM 448 G NK++IEEA+RS+HDALCVIR L++ ++ GGGA EI AL +++ + +E Y + Sbjct: 395 GSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYCI 454 Query: 449 RAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIE 508 RAFADA+EVIP L+EN+G+NPI T+TE+R R + GI+ G +++ ++ V++ Sbjct: 455 RAFADAMEVIPSTLAENAGLNPISTVTELRNRHA-QGEKTTGINVRKGGISNILEELVVQ 513 Query: 509 TLIGKKQQISLATQMVRMILKIDDI 533 L+ ++LAT+ VR ILKIDD+ Sbjct: 514 PLLVSVSALTLATETVRSILKIDDV 538 >5GW4-d nrPDB Length = 528 Score = 327 bits (839), Expect = 6e-90, Method: Compositional matrix adjust. Identities = 190/515 (36%), Positives = 315/515 (61%), Gaps = 22/515 (4%) Query: 32 EALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLM 91 E K++I+AA++VA+ +RTSLGP G+DKM+ G++ ++NDG TIL M + H +A+++ Sbjct: 19 EVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPVARML 78 Query: 92 VELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKI 151 VE+S +QD E GDGTT VV+L GALL AE+LL++GIHP IAD ++ AA+ +++ L ++ Sbjct: 79 VEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDILLEM 138 Query: 152 SDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKV 211 V + D E L++ A T+L SK+V+ +A +AV++VL ++D ++VD I++ Sbjct: 139 CHK--VSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKNVDLNDIRL 196 Query: 212 EGKVGGRLEDTKLIKGVIVDKD-FSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTS 270 KVGG ++DT++I GV++ + P + E AKI ++ PPKP T++ + Sbjct: 197 VKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNI---I 253 Query: 271 VEDYKALQKYEKEKFEEMIQQIKETGANL--------AICQWGFDDEANHLLLQNNLPAV 322 V DY+ + K KE+ ++ K+ +I + +D A H L + N+ V Sbjct: 254 VNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIMVV 313 Query: 323 RWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRA 382 + + EIE ++ G + + T ++LG A LV+EI + K++ + +N+ A Sbjct: 314 KDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEID--SDGSKIVRVTGIRNNNA 371 Query: 383 ---VTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADK 439 V++ IRG N MII+E +RSLHDALCVIR L+++ ++ GGGA EI + +S+EA Sbjct: 372 RPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARS 431 Query: 440 CPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVK-EMNPALGIDCLHKGT 498 ++ + + FA ALEVIP L+EN+G+N I+ +TE+R++ E+N GI GT Sbjct: 432 MEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELND--GISVRRSGT 489 Query: 499 NDMKQQHVIETLIGKKQQISLATQMVRMILKIDDI 533 + ++H+++ ++ I+LA++ V+ IL+IDDI Sbjct: 490 TNTYEEHILQPVLVSTSAITLASECVKSILRIDDI 524 >3AQ1-B nrPDB Length = 500 Score = 325 bits (833), Expect = 3e-89, Method: Compositional matrix adjust. Identities = 182/477 (38%), Positives = 291/477 (61%), Gaps = 8/477 (1%) Query: 60 MMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEE 119 M+VD GD+ +TNDGATIL MD+ H AK++VE+SK+QD E+GDGTT VL+G LL + Sbjct: 1 MLVDSMGDIVITNDGATILKEMDIQHPAAKMIVEVSKTQDAEVGDGTTTAAVLSGELLSK 60 Query: 120 AEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVN 179 AE+L+ +G+H I++GY AA E L+ I+ ++ D D LI+ A T + K Sbjct: 61 AEELIMKGVHSTIISEGYRHAAEKCREILETITIAISPD--DEAALIKIAGTAITGKGAE 118 Query: 180 SCHRQMAEIAVNAVLTVADMERRDVD---FELIKVEGKVGGRLEDTKLIKGVIVDKDFSH 236 + +++ + V AV ++ + E + E IK+E + GG ++D++LI G+++DK+ SH Sbjct: 119 AYKEKLSALTVKAVRSIVEEEEDGLKVNVLENIKIEKRAGGSIDDSELIDGLVIDKERSH 178 Query: 237 PQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETG 296 P MP+KVE+AKI +L+CP E K + ++ +TS + E++ EM +++ +G Sbjct: 179 PNMPEKVENAKILLLSCPVEFRKTEVDSEIKITSPGQMQLFLDQEEKMMREMAEKVIASG 238 Query: 297 ANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFA 356 AN+ CQ G DD A + + + + AVR V +++ ++ TG I+ ++T E +G A Sbjct: 239 ANVVFCQKGIDDMAQYYIEKAGIYAVRRVKKSDLKRLSKVTGATIIQDLDQITTEDVGTA 298 Query: 357 GLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDN 416 GLV+E KM + C+NS+AVT+ + GG + +++ +L+DAL V+ +I D Sbjct: 299 GLVEEKEV--RGGKMTYVTGCQNSKAVTVLLHGGTEHVVDSLDHALNDALHVVGVVIEDG 356 Query: 417 RVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTE 476 +VV GGG++E+ +L +S+ A EQ A+ FA+ALEVIP+AL+EN+G++PI M E Sbjct: 357 KVVVGGGSSEVELSLRLSEYASTLKGREQLAVSKFAEALEVIPVALAENAGLDPIDIMVE 416 Query: 477 VRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDI 533 +R++ K N G++ DM + VIE L K Q I+ A + MIL+IDD+ Sbjct: 417 LRSQHEKG-NKNAGLNVYTGEVVDMWENDVIEPLRIKTQAINAAMEATVMILRIDDV 472 >4B2T-G nrPDB Length = 545 Score = 302 bits (773), Expect = 3e-82, Method: Compositional matrix adjust. Identities = 179/524 (34%), Positives = 306/524 (58%), Gaps = 10/524 (1%) Query: 14 RPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTND 73 RP L++ + R G + +I AAK +A+ +RT LGP + KM++D G + +TND Sbjct: 5 RPVLVLSQNTK--RESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTND 62 Query: 74 GATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRI 133 G IL + V H AK M+E+S++QD+E+GDGTT V++LAG +L AE L++ +HP + Sbjct: 63 GNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVV 122 Query: 134 ADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAV 193 Y +A I L KI S+ VD + + ++ +++ +KV++ IA++AV Sbjct: 123 ISAYRKALDDMISTLKKI--SIPVDTSNRDTMLNIINSSITTKVISRWSSLACNIALDAV 180 Query: 194 LTVADME--RRDVDF-ELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAI 250 TV E R+++D + +VE GG +ED+ +++GV+++KD +HP+M + +++ +I + Sbjct: 181 KTVQFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVL 240 Query: 251 LTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEA 310 L E K +++ +++T ED+ + + E+E +++ + I + ++ I + G D A Sbjct: 241 LDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLA 300 Query: 311 NHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGF-AGLVQEISFGTTKD 369 H L++ N+ A+R V + IA A G RIV R EL E +G AGL++ G + Sbjct: 301 QHYLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREEDVGTGAGLLEIKKIG--DE 358 Query: 370 KMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISC 429 I +CK+ +A TI +RG +K I+ E +R+L DA+ V RN++ D ++V GGGA+E++ Sbjct: 359 YFTFITECKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAV 418 Query: 430 ALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPAL 489 A A+++++ +EQ+ RA A ALEVIP L +N G + I+ +T +RA+ +E Sbjct: 419 AHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETW 478 Query: 490 GIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDI 533 G++ DMK+ + E L K Q A + ++L+IDDI Sbjct: 479 GVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDI 522 >5GW5-g nrPDB Length = 534 Score = 287 bits (735), Expect = 8e-78, Method: Compositional matrix adjust. Identities = 175/524 (33%), Positives = 304/524 (58%), Gaps = 24/524 (4%) Query: 25 KSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVD 84 + R G +A S+I AAKAVA+ +RT LGP + KM++D G + +TNDG IL +DV Sbjct: 12 QERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVA 71 Query: 85 HQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEE-AEQLLDRGIHPIRIADGYEQAARV 143 H AK M+ELS++QD+E+GDGTT V++LAG +L + A L+++ IHP+ I ++A Sbjct: 72 HPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTD 131 Query: 144 AIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRD 203 A+E + ++S VD+++ + + + ++G+K V +M E+A++AV TV R+D Sbjct: 132 ALEVIKQVSKP--VDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTV----RKD 185 Query: 204 V--------DFEL-----IKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAI 250 + +FE+ ++VE GG + D++++KGV+++KD HP+M + +E+ ++ + Sbjct: 186 LGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVVL 245 Query: 251 LTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEA 310 L CP E K +++ +++ ED+ + + E+E+ + M +QI L I + G D A Sbjct: 246 LDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSDLA 305 Query: 311 NHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGF-AGLVQEISFGTTKD 369 H LL+ +R V + IA TG IV R +L +G GL + G + Sbjct: 306 QHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIG--DE 363 Query: 370 KMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISC 429 ++ CK +A TI +RGG+K I+ E R+L DA+ V RN++ + GGGA E++ Sbjct: 364 YFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAV 423 Query: 430 ALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPAL 489 ++ ++++A + ++Q+ +A ADA+E IP L +N+G +PI+ ++++RA+ + N Sbjct: 424 SVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHA-QGNFTT 482 Query: 490 GIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDI 533 GID DM + E + K+Q + A + ++L++DDI Sbjct: 483 GIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDI 526 >4B2T-A nrPDB Length = 556 Score = 264 bits (675), Expect = 7e-71, Method: Compositional matrix adjust. Identities = 172/521 (33%), Positives = 290/521 (55%), Gaps = 20/521 (3%) Query: 32 EALKS-HIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKL 90 EA++S ++MAA ++AN +++SLGP GLDKM+VD GDVT+TNDGATIL +++V+H AK+ Sbjct: 15 EAIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLLEVEHPAAKV 74 Query: 91 MVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDK 150 + EL+ QD E+GDGTT VV++A LL+ A++L+ + IHP + GY A + A+ + Sbjct: 75 LCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLACKEAVRY--- 131 Query: 151 ISDSVLVDIKDT--EPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRD---VD 205 IS++++++ + + LI AKT++ SKV+ A + V+AVL + + R Sbjct: 132 ISENLIINTDELGRDCLINAAKTSMSSKVIGINGDFFANLVVDAVLAIKYTDIRGQPRYP 191 Query: 206 FELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHK 265 I V G ++ LI G ++ MPK++ +AKIA L + K K + Sbjct: 192 VNSINVLKAHGRSQMESMLINGYALNCVVGSQGMPKRIVNAKIACLDFSLQKTKMKLGVQ 251 Query: 266 LDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWV 325 + +T E +++ E + +E IQ+I TGAN+ + G DD ++ AVR V Sbjct: 252 VVITDPEKLDQIRQRESDITKERIQKILATGANVILTTGGIDDMCLKYFVEAGAMAVRRV 311 Query: 326 GGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQE----ISFGTTKDKMLVIEQCKNSR 381 +++ IA A+G ++ + L E+ A ++ + + D++++I+ K Sbjct: 312 LKRDLKRIAKASGATVLSTLANLEGEETFEASMLGQAEEVVQERICDDELILIKNTKART 371 Query: 382 AVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCP 441 + ++ +RG N + +E +RSLHDALCV++ ++ VV GGGA E + ++ + A Sbjct: 372 SASVILRGANDFMCDEMERSLHDALCVVKRVLESKSVVPGGGAVEAALSIYLENYATSMG 431 Query: 442 TLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRA-RQVKEMNPA------LGIDCL 494 + EQ A+ FA +L VIP L+ N+ + + ++RA ++NP +G+D + Sbjct: 432 SREQLAIAEFARSLPVIPNTLAVNAAQDSTDLVAKLRAFHNEAQVNPERKNLKWIGLDLV 491 Query: 495 HKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRK 535 + D KQ V E I K + + AT+ IL+IDD+ K Sbjct: 492 NGKPRDNKQAGVFEPTIVKVKSLKFATEAAITILRIDDLIK 532 >4V8R-AB nrPDB Length = 527 Score = 259 bits (661), Expect = 3e-69, Method: Compositional matrix adjust. Identities = 178/505 (35%), Positives = 285/505 (56%), Gaps = 18/505 (3%) Query: 36 SHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVT-VTNDGATILSMMDVDHQIAKLMVEL 94 S + A AV + ++++LGP G+DK++ + VTNDGATIL + +D+ AK++V + Sbjct: 21 SAFVGAIAVGDLVKSTLGPKGMDKLLQSASSNTCMVTNDGATILKSIPLDNPAAKVLVNI 80 Query: 95 SKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRG-IHPIRIADGYEQAARVAIEHLDKIS- 152 SK QDDE+GDGTT V VL+ LL EAE+L+D+ IHP I +GY A+ A++ L K + Sbjct: 81 SKVQDDEVGDGTTSVTVLSAELLREAEKLIDQSKIHPQTIIEGYRLASAAALDALTKAAV 140 Query: 153 DSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVE 212 D+ E LI AKTTL SK+++ AE+A NA+L + + + E I++ Sbjct: 141 DNSHDKTMFREDLIHIAKTTLSSKILSQDKDHFAELATNAILRL----KGSTNLEHIQII 196 Query: 213 GKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPK---TKHKLDVT 269 +GG+L D+ L +G I+ K F + Q PK++E+AKI I + K K TK K+D T Sbjct: 197 KILGGKLSDSFLDEGFILAKKFGNNQ-PKRIENAKILIANTTLDTDKVKIFGTKFKVDST 255 Query: 270 SVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPE 329 + L+K E+EK + I +I + G N I + D L + ++ Sbjct: 256 A--KLAQLEKAEREKMKNKIAKISKFGINTFINRQLIYDYPEQLFTDLGINSIEHADFEG 313 Query: 330 IELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRG 389 +E +A+ TGG +V F E + KLG +++EI G + L CK A TI +RG Sbjct: 314 VERLALVTGGEVVSTFDEPSKCKLGECDVIEEIMLG--EQPFLKFSGCKAGEACTIVLRG 371 Query: 390 GNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMR 449 ++EA+RSLHDAL V+ ++ R V GGG AE+ + AV EA + A+ Sbjct: 372 ATDQTLDEAERSLHDALSVLSQTTKETRTVLGGGCAEMVMSKAVDTEAQNIDGKKSLAVE 431 Query: 450 AFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGT-NDMKQQHVIE 508 AFA AL +P L++N+G + + ++++R+ ++ + G+D L+ GT DM+Q ++E Sbjct: 432 AFARALRQLPTILADNAGFDSSELVSKLRSSIYNGISTS-GLD-LNNGTIADMRQLGIVE 489 Query: 509 TLIGKKQQISLATQMVRMILKIDDI 533 + K+ +S A++ ++L++D+I Sbjct: 490 SYKLKRAVVSSASEAAEVLLRVDNI 514 >5GW4-h nrPDB Length = 550 Score = 257 bits (657), Expect = 7e-69, Method: Compositional matrix adjust. Identities = 157/501 (31%), Positives = 273/501 (54%), Gaps = 10/501 (1%) Query: 36 SHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELS 95 S+I A AV ++ +LGP G D ++V + T++NDGATIL ++DV H AK +V++S Sbjct: 28 SNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVHPAAKTLVDIS 87 Query: 96 KSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSV 155 ++QD E+GDGTT V +LAG L++EA+ L+ GI I GY +A +A+E +++++ + Sbjct: 88 RAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAVEKINELAVDI 147 Query: 156 LVDIKDTEPLIQ-TAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGK 214 + L++ A+T + SK++++ ++ V+AVL+ ++R D+D +LI ++ Sbjct: 148 TSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLS---LDRNDLDDKLIGIKKI 204 Query: 215 VGGRLEDTKLIKGVIVDKDFSHP---QMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSV 271 GG +E++ I GV K FS+ Q PKK + KI L E K ++ V V Sbjct: 205 PGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELELKAEKDNAEVRVEHV 264 Query: 272 EDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIE 331 EDY+A+ E + E ++Q++ETGAN+ + + D A N+ V ++ Sbjct: 265 EDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRVSADDMN 324 Query: 332 LIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGN 391 + A GG I S++ E LG L +E+ G+ + + + C ++ T+ +RGG Sbjct: 325 RVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNLF--QGCPQAKTCTLLLRGGA 382 Query: 392 KMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAF 451 + +I E +RSLHDA+ +++ +++ +V GGGA E+ + + + +Q + AF Sbjct: 383 EQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYSKTIAGKQQMIINAF 442 Query: 452 ADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLI 511 A ALEVIP L EN+G + I+ + ++R K G+ + D + V E + Sbjct: 443 AKALEVIPRQLCENAGFDAIEILNKLRLAHSKG-EKWYGVVFETENIGDNFAKFVWEPAL 501 Query: 512 GKKQQISLATQMVRMILKIDD 532 K ++ AT+ +IL +D+ Sbjct: 502 VKINALNSATEATNLILSVDE 522 >4B2T-H nrPDB Length = 543 Score = 250 bits (639), Expect = 9e-67, Method: Compositional matrix adjust. Identities = 156/528 (29%), Positives = 287/528 (54%), Gaps = 15/528 (2%) Query: 15 PFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDG 74 P +++K+ S+ G+ L S+I A + +A +RT+LGP G+DK++VD G T++NDG Sbjct: 5 PVILLKEGTDSSQ--GIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDG 62 Query: 75 ATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIA 134 ATIL ++DV H AK +V+++KSQD E+GDGTT V +LA L++ + ++ G+HP I Sbjct: 63 ATILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIII 122 Query: 135 DGYEQAARVAIEHLDKISDSVLVD--IKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNA 192 + A ++A+ + +I+ +V + ++ + L + A T L SK+++ A++ V+A Sbjct: 123 RAFRTATQLAVNKIKEIAVTVKKEDKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDA 182 Query: 193 VLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQM---PKKVEDAKIA 249 V+ + D+ + ++I ++ GG LE+++L+ GV K FS+ PKK + IA Sbjct: 183 VMMLDDL----LQLKMIGIKKVQGGALEESQLVAGVAFKKTFSYAGFEMQPKKYHNPMIA 238 Query: 250 ILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDE 309 +L E K ++ V +VEDY+A+ E + +++I +GA + + + D Sbjct: 239 LLNVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGDV 298 Query: 310 ANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKD 369 A ++ V +++ +A GG I + L+++ LG + +E G + Sbjct: 299 ATQYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALSSDVLGRCQVFEETQIGGERY 358 Query: 370 KMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISC 429 C ++ TI +RGG + +EE +RSLHDA+ ++R I+++ VV GGGA E+ Sbjct: 359 NFFT--GCPKAKTCTIILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMEL 416 Query: 430 ALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPAL 489 + + + P +Q + A+A ALE+IP L +N+G + + ++RAR + Sbjct: 417 SKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHA-QGGMWY 475 Query: 490 GIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDD-IRKP 536 G+D + D + V E + + ++ A++ +I+ +D+ I+ P Sbjct: 476 GVDINTEDIADNFEAFVWEPAMVRINALTAASEAACLIVSVDETIKNP 523 >4B2T-B nrPDB Length = 535 Score = 250 bits (639), Expect = 9e-67, Method: Compositional matrix adjust. Identities = 172/504 (34%), Positives = 277/504 (54%), Gaps = 12/504 (2%) Query: 36 SHIMAAKAVANTMRTSLGPNGLDKMMVD--KDGDVTVTNDGATILSMMDVDHQIAKLMVE 93 S + A A+ + ++++LGP G+DK+++ +D + VTNDGATIL + VD+ AK++V+ Sbjct: 27 SSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGATILKNIGVDNPAAKVLVD 86 Query: 94 LSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHL-DKIS 152 +S+ QDDE+GDGTT V VLA LL EAE L+ + IHP I G+ +A + A + L + Sbjct: 87 MSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIAGWREATKAARQALLNSAV 146 Query: 153 DSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVE 212 D ++K + L+ A TTL SK++ ++AV AVL + + + E I V Sbjct: 147 DHGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRL----KGSGNLEAIHVI 202 Query: 213 GKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKT-KHKLDVTSV 271 K+GG L D+ L +G ++DK Q PK++E+AKI I + K K ++ V S Sbjct: 203 KKLGGSLADSYLDEGFLLDKKIGVNQ-PKRIENAKILIANTGMDTDKIKIFGSRVRVDST 261 Query: 272 EDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIE 331 ++ EKEK +E +++I + G N I + + L + A+ +E Sbjct: 262 AKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHADFVGVE 321 Query: 332 LIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGN 391 +A+ TGG I F KLG L++E+ G +DK++ A TI +RG Sbjct: 322 RLALVTGGEIASTFDHPELVKLGSCKLIEEVMIG--EDKLIHFSGVALGEACTIVLRGAT 379 Query: 392 KMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAF 451 + I++EA+RSLHDALCV+ ++D+R VYGGG +E+ A AV+Q A + P E AM ++ Sbjct: 380 QQILDEAERSLHDALCVLAQTVKDSRTVYGGGCSEMLMAHAVTQLASRTPGKEAVAMESY 439 Query: 452 ADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLI 511 A AL ++P +++N+G + + ++RA E G+D DM + E+ Sbjct: 440 AKALRMLPTIIADNAGYDSADLVAQLRAAH-SEGKTTAGLDMKEGTIGDMSVLGITESFQ 498 Query: 512 GKKQQISLATQMVRMILKIDDIRK 535 K+Q + A + +IL++D+I K Sbjct: 499 VKRQVLLSAAEAAEVILRVDNIIK 522 >4B2T-Z nrPDB Length = 531 Score = 236 bits (602), Expect = 2e-62, Method: Compositional matrix adjust. Identities = 165/519 (31%), Positives = 276/519 (53%), Gaps = 22/519 (4%) Query: 33 ALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMV 92 AL +I AA+ + + +RT+LGP G KM+V GD+ +T DG +L M + H A L+ Sbjct: 19 ALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQIQHPTASLIA 78 Query: 93 ELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKIS 152 +++ +QDD GDGTT V++ G LL++A+ + G+HP I +G+E A A++ L+++ Sbjct: 79 KVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQFLEQVK 138 Query: 153 DSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVL-TVADMERRDVDFELIKV 211 S + D E LI A+T+L +KV H ++A++ AV+ ++ ++++D +L V Sbjct: 139 VSKEM---DRETLIDVARTSLRTKV----HAELADVLTEAVVDSILAIKKQDEPIDLFMV 191 Query: 212 E-GKVGGRLE-DTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVT 269 E ++ + E DT LI+G+++D HP M K+VEDA I E K + Sbjct: 192 EIMEMKHKSETDTSLIRGLVLDHGARHPDMKKRVEDAYILTCNVSLEYEKTEVNSGFFYK 251 Query: 270 SVEDYKALQKYEKEKFEEMIQQIKETGANLA---------ICQWGFDDEANHLLLQNNLP 320 S E+ + L K E++ E+ +++I E + I Q G D + L + + Sbjct: 252 SAEEREKLVKAERKFIEDRVKKIIELKKKVCGDSDKGFVVINQKGIDPFSLDALAKEGII 311 Query: 321 AVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNS 380 A+R +E + +A GG + +L + LG AGLV E + G ++K IE+C N Sbjct: 312 ALRRAKRRNMERLTLACGGIALNSLDDLNPDCLGHAGLVYEYTLG--EEKFTFIEKCNNP 369 Query: 381 RAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKC 440 R+VT+ I+G NK + + K ++ D L ++N I D VV G GA E++ A A+ + Sbjct: 370 RSVTLLIKGPNKHTLTQIKDAIRDGLRAVKNAIDDGCVVPGAGAVEVAMAEALVKYKPSV 429 Query: 441 PTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTND 500 Q ++AFADAL +IP L++NSG + +T+ +V+A E +G+D Sbjct: 430 KGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKVQAEH-SESGQLVGVDLNTGEPMV 488 Query: 501 MKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGES 539 + + + KKQ + T + IL +D+I + G S Sbjct: 489 AAEAGIWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMS 527 >4V94-A nrPDB Length = 559 Score = 225 bits (574), Expect = 3e-59, Method: Compositional matrix adjust. Identities = 157/518 (30%), Positives = 265/518 (51%), Gaps = 27/518 (5%) Query: 37 HIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSK 96 +++A AVAN +++SLGP GLDKM+VD GD TVTNDGATILS++DV H K++VEL++ Sbjct: 29 NVLATMAVANVVKSSLGPVGLDKMLVDDIGDFTVTNDGATILSLLDVQHPAGKILVELAQ 88 Query: 97 SQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVL 156 QD EIGDGTT VV++A LL+ A +L+ IHP I G+ A R AI ++++ S Sbjct: 89 QQDREIGDGTTSVVIIASELLKRANELVKNKIHPTTIITGFRVALREAIRFINEVL-STS 147 Query: 157 VDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERR-DVDF-----ELIK 210 VD E LI AKT++ SK++ + + + V+A+L V + ++ + ++K Sbjct: 148 VDTLGKETLINIAKTSMSSKIIGADSDFFSNMVVDALLAVKTQNSKGEIKYPVKAVNVLK 207 Query: 211 VEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVE--DAKIAILTCPFEPPKPKTKHKLDV 268 GK ++ L+ G ++ + MPK++ + KIA L + + ++++ Sbjct: 208 AHGKSA---TESLLVPGYALNCTVASQAMPKRIAGGNVKIACLDLNLQKARMAMGVQINI 264 Query: 269 TSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGP 328 E + ++K E E +++I + GA + + G DD ++ + VR Sbjct: 265 DDPEQLEQIRKREAGIVLERVKKIIDAGAQVVLTTKGIDDLCLKEFVEAKIMGVRRCKKE 324 Query: 329 EIELIAIATGGRIVPRFSELTAEKL---GFAGLVQE-ISFGTTKDKMLVIEQCKNSRAVT 384 ++ IA ATG +V S L E+ + GL E + + D+ ++I+ + + Sbjct: 325 DLRRIARATGATLVSSMSNLEGEETFESSYLGLCDEVVQAKFSDDECILIKGTSKHSSSS 384 Query: 385 IFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLE 444 I +RG N ++E +RSLHD+L V++ + VV GGG E + + + A + E Sbjct: 385 IILRGANDYSLDEMERSLHDSLSVVKRTLESGNVVPGGGCVEAALNIYLDNFATTVGSRE 444 Query: 445 QYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQV-----------KEMNPALGIDC 493 Q A+ FA AL +IP L+ N+ + + + ++R+ + G+D Sbjct: 445 QLAIAEFAAALLIIPKTLAVNAAKDSSELVAKLRSYHAASQMAKPEDVKRRSYRNYGLDL 504 Query: 494 LHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKID 531 + D V+E I K + + A + IL+ID Sbjct: 505 IRGKIVDEIHAGVLEPTISKVKSLKSALEACVAILRID 542 >4B2T-Q nrPDB Length = 548 Score = 209 bits (533), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 162/504 (32%), Positives = 264/504 (52%), Gaps = 8/504 (1%) Query: 32 EALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLM 91 EA+ +I A K +A T RT+ GPNG++KM+++ + VTND ATIL ++V H AK++ Sbjct: 27 EAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATILRELEVQHPAAKMI 86 Query: 92 VELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKI 151 V S Q+ E+GDGT V+V AGALLE AE+LL G+ + +GYE A + A E L + Sbjct: 87 VMASHMQEQEVGDGTNFVLVFAGALLELAEELLRLGLSVSEVIEGYEIACKKAHEILPDL 146 Query: 152 SDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKV 211 +++D + + T++ SK + IA V D +VD I+V Sbjct: 147 VCCSAKNLRDVDEVSSLLHTSVMSKQYGNEVFLAKLIAQACVSIFPDSGHFNVDN--IRV 204 Query: 212 EGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSV 271 +G + + ++ G++ K+ V+DAKIA+ +CPF+ +TK + + S Sbjct: 205 CKILGSGVHSSSVLHGMVFKKETEGDVT--SVKDAKIAVYSCPFDGMITETKGTVLIKSA 262 Query: 272 EDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIE 331 E+ K E+ + ++ I +TGAN+ + D A H + N+ VR ++ Sbjct: 263 EELMNFSKGEENLMDAQVKAIADTGANVVVTGGRVADMALHYANKYNIMLVRLNSKWDLR 322 Query: 332 LIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAV-TIFIRGG 390 + G +PR + E++G V G T +++V + K A+ TI +RG Sbjct: 323 RLCKTVGATALPRLNPPVLEEMGHCDSVYLSEVGDT--QVVVFKHEKEDGAISTIVLRGS 380 Query: 391 NKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRA 450 ++++ +R++ D + + L RD R+V GGGA EI A ++ + CP LEQYA++ Sbjct: 381 TDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSYGETCPGLEQYAIKK 440 Query: 451 FADALEVIPMALSENSGMNPIQTMTEVRA-RQVKEMNPALGIDCLHKGTNDMKQQHVIET 509 FA+A E IP AL+ENSG+ + ++++ A Q N L I+ DM + V++T Sbjct: 441 FAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGLDIEAEVPAVKDMLEAGVLDT 500 Query: 510 LIGKKQQISLATQMVRMILKIDDI 533 +GK I LAT +L++D I Sbjct: 501 YLGKYWAIKLATNAAVTVLRVDQI 524 >5GW5-z nrPDB Length = 546 Score = 201 bits (511), Expect = 7e-52, Method: Compositional matrix adjust. Identities = 144/526 (27%), Positives = 268/526 (50%), Gaps = 23/526 (4%) Query: 33 ALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMV 92 ALK ++ +A+ + + + T+LGP G KM+VD G++ +T DG +L+ M + A L+ Sbjct: 18 ALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIA 77 Query: 93 ELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLD--K 150 + +QD+ GDGTT VV L G LL +A + + G+HP I DG+E A + +++ LD K Sbjct: 78 RAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFK 137 Query: 151 ISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIK 210 IS + L + D E L+Q A+++L +KV + I +AVL+V D + ++D +++ Sbjct: 138 ISKTNLSN--DREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADNLDLHMVE 195 Query: 211 VEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTS 270 + +DT IKG+++D HP MP +V++A + IL E K + +S Sbjct: 196 IMQMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSS 255 Query: 271 VEDYKALQKYEKEKFEEMIQQIKETGANLA----------ICQWGFDDEANHLLLQNNLP 320 + L E++ + +++I + + I Q G D + + ++N+ Sbjct: 256 ADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNIL 315 Query: 321 AVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNS 380 A+R +E + + TGG +L+ + LGF+GLV + + G ++K + + + Sbjct: 316 ALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIG--EEKFTYVTENTDP 373 Query: 381 RAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAV-SQEADK 439 ++ TI I+G + + K ++ D L + N+++D ++ G GA I+ + + S +K Sbjct: 374 KSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNK 433 Query: 440 --CPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMT----EVRARQVKEMNPALGIDC 493 + + AFA+AL VIP L +NSG +P+ + E+ Q + +G+D Sbjct: 434 LGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDL 493 Query: 494 LHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGES 539 + D + + ++ + I+ AT + +L D++ + G S Sbjct: 494 NIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRS 539 >4V8R-AG nrPDB Length = 590 Score = 198 bits (504), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 119/344 (34%), Positives = 202/344 (58%), Gaps = 20/344 (5%) Query: 25 KSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVD 84 + R G +A S+I AAKAVA+ +RT LGP + KM++D G + +TNDG IL +DV Sbjct: 12 QERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVA 71 Query: 85 HQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEE-AEQLLDRGIHPIRIADGYEQAARV 143 H AK M+ELS++QD+E+GDGTT V++LAG +L + A L+++ IHP+ I ++A Sbjct: 72 HPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTD 131 Query: 144 AIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRD 203 A+E + ++S VD+++ + + + ++G+K V +M E+A++AV TV R+D Sbjct: 132 ALEVIKQVSKP--VDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAVKTV----RKD 185 Query: 204 V--------DFEL-----IKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAI 250 + +FE+ ++VE GG + D++++KGV+++KD HP+M + +E+ ++ + Sbjct: 186 LGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIENPRVVL 245 Query: 251 LTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEA 310 L CP E K +++ +++ ED+ + + E+E+ + M +QI L I + G D A Sbjct: 246 LDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSDLA 305 Query: 311 NHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLG 354 H LL+ +R V + IA TG IV R +L +G Sbjct: 306 QHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVG 349 Score = 95.5 bits (236), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 51/153 (33%), Positives = 93/153 (60%), Gaps = 1/153 (0%) Query: 381 RAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKC 440 +A TI +RGG+K I+ E R+L DA+ V RN++ + GGGA E++ ++ ++++A + Sbjct: 431 KACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAVSVKLAEKAKQL 490 Query: 441 PTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTND 500 ++Q+ +A ADA+E IP L +N+G +PI+ ++++RA+ + N GID D Sbjct: 491 EGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHA-QGNFTTGIDGDKGKIVD 549 Query: 501 MKQQHVIETLIGKKQQISLATQMVRMILKIDDI 533 M + E + K+Q + A + ++L++DDI Sbjct: 550 MVSYGIWEPEVIKQQSVKTAIESACLLLRVDDI 582 >5GW5-q nrPDB Length = 568 Score = 196 bits (498), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 135/513 (26%), Positives = 265/513 (51%), Gaps = 17/513 (3%) Query: 38 IMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKS 97 I A + + TS+GP G +K++V+ G + +TND AT+L +D+ H K++V ++ Sbjct: 32 IAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVHPAVKVLVMATEQ 91 Query: 98 QDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLV 157 Q ++GDGT V++LAG LL +E+L+ G+ + I GY A + ++ LD++ + Sbjct: 92 QKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNMARKFTLKELDEMVVGEIT 151 Query: 158 DIKDTEPLIQTAKTTLGSKVVNS--CHRQMAEIAVNAVLTVADM--ERRDVDFELIKVEG 213 D D L++ K + SK S ++ AV+ VL VA E + + I+V Sbjct: 152 DKNDKNELLKMIKPVISSKKYGSEDILSELVSEAVSHVLPVAQQAGEIPYFNVDSIRVVK 211 Query: 214 KVGGRLEDTKLIKGVIVDKDF-SHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVE 272 +GG L ++ +IKG++ +++ H + + + K+A+ TCP + +TK + + + + Sbjct: 212 IMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFTCPLDIANTETKGTVLLHNAQ 271 Query: 273 DYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIEL 332 + K E+++ + M+++I + G + G + A H L + + ++ E+ Sbjct: 272 EMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGELALHYLNRYGILVLKVPSKFELRR 331 Query: 333 IAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNK 392 + G +PR T E+LG V+ + G + + EQ + SR TI +RG + Sbjct: 332 LCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGDRVTVFKQEQGEISRTSTIILRGATQ 391 Query: 393 MIIEEAKRSLHDALCVIRNLIRDN--RVVYGGGAAEISCALAVSQEADKCPTLEQYAMRA 450 +++ +R++ D + ++ L++ + +++ G GA EI +++ ++ P L Q A++ Sbjct: 392 NNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATEIELISRITKYGERTPGLLQLAIKQ 451 Query: 451 FADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTN----------D 500 FA A EV+P L+E +G++ + + + A A+ D L+KG + D Sbjct: 452 FAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPGAVKTDHLYKGVDIDGESDEGVKD 511 Query: 501 MKQQHVIETLIGKKQQISLATQMVRMILKIDDI 533 ++++++ + L KK I++AT+ +L ID I Sbjct: 512 IREENIYDMLATKKFAINVATEAATTVLSIDQI 544 >5X9V-A nrPDB Length = 521 Score = 176 bits (446), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 144/510 (28%), Positives = 250/510 (49%), Gaps = 27/510 (5%) Query: 32 EALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLM 91 +AL S+ A KA+ + SLGP GLD M+VD+ G+V VTNDG TIL++MD H A+++ Sbjct: 15 QALFSNAAAVKALTQVVANSLGPKGLDAMLVDRFGEVVVTNDGVTILTLMDAQHPAARMV 74 Query: 92 VELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKI 151 V ++++Q+ E+GDGTT VLAGAL+ E + +G+ ++ G +A A+ + K Sbjct: 75 VNMARAQEREVGDGTTTAAVLAGALVSEGVNQILKGVPVSKVLAGMNRALNHALFLIRK- 133 Query: 152 SDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIK- 210 +++ V + L+ A K+ ++A I +A + D + +D F+L Sbjct: 134 -NAIKVGSITDDRLLAAA------KIAGRGDERVAAILRDAAAMLED-KLQDPGFKLADL 185 Query: 211 VEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTS 270 V KVG DT LI GV+++K + +K+++ ++ +L P + + + Sbjct: 186 VLAKVGA---DTTLIPGVVINKSPLWEEGSQKLQEVRLLVLDDGLYPEEVEEEALASEAG 242 Query: 271 VEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEI 330 E Y QK F+E ++++KE G L + G D A +N + + + E+ Sbjct: 243 FEQYLKNQKI----FQENLKKLKELGVKLILLTRGISDIAEEFCYENEIMVITRITQKEL 298 Query: 331 ELIAIATGGRIVPRFS-----ELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTI 385 + + TG R R S E + LG+A F ++ +IE T+ Sbjct: 299 KRVLEFTGARAAKRTSLNKPVEELQKMLGYA----RTCFYDSRLDFTIIEGGAGKATATV 354 Query: 386 FIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQ 445 I +++E +R DA R V+ GGGA + + V ++ P +E Sbjct: 355 LIGAATDEVVDEQERIAKDAAGSFAAAYRSG-VLPGGGAFFLYLSREVESLKNRLPGMES 413 Query: 446 YAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQH 505 Y + AF++AL+V ++EN+G N ++ + ++ QV++ N ALG+D DM Sbjct: 414 YGVMAFSEALKVPFRVMAENAGFNGLEKLGDLMTLQVQKNNYALGLDFETGEFIDMIAGG 473 Query: 506 VIETLIGKKQQISLATQMVRMILKIDDIRK 535 V++ Q + A+++ +LKI+ I K Sbjct: 474 VVDPAEVVYQAVKNASEVAISLLKINTIIK 503 >1E0R-B nrPDB Length = 159 Score = 102 bits (253), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 61/158 (38%), Positives = 88/158 (55%), Gaps = 8/158 (5%) Query: 225 IKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKY---E 281 + G+IVDK+ HP MP V+DAKIA+L P E KP+ L +ED +QK+ E Sbjct: 1 MNGIIVDKEKVHPGMPDVVKDAKIALLDAPLEIKKPEFDTNL---RIEDPSMIQKFLAQE 57 Query: 282 KEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRI 341 + EM+ +IK GAN+ I Q G DD A H L + + AVR V +++ +A ATG I Sbjct: 58 ENMLREMVDKIKSVGANVVITQKGIDDMAQHYLSRAGIYAVRRVKKSDMDKLAKATGASI 117 Query: 342 VPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKN 379 V E+++ LG A V+++ G +D M + KN Sbjct: 118 VSTIDEISSSDLGTAERVEQVKVG--EDYMTFVTGSKN 153 >1ASS-A nrPDB Length = 159 Score = 100 bits (250), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 54/153 (35%), Positives = 88/153 (57%), Gaps = 2/153 (1%) Query: 227 GVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFE 286 G+++DK+ H +MP V++AKIA++ E K + + K+ ++ + E F+ Sbjct: 3 GIVIDKEKVHSKMPDVVKNAKIALIDSALEIKKTEIEAKVQISDPSKIQDFLNQETNTFK 62 Query: 287 EMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFS 346 +M+++IK++GAN+ +CQ G DD A H L + + AVR V ++E +A ATG +IV Sbjct: 63 QMVEKIKKSGANVVLCQKGIDDVAQHYLAKEGIYAVRRVKKSDMEKLAKATGAKIVTDLD 122 Query: 347 ELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKN 379 +LT LG A V+E G D+M + CKN Sbjct: 123 DLTPSVLGEAETVEERKIGD--DRMTFVMGCKN 153 >1GN1-A nrPDB Length = 178 Score = 95.1 bits (235), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 52/174 (29%), Positives = 99/174 (56%), Gaps = 3/174 (1%) Query: 219 LEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQ 278 +ED+ +++GV+++KD +HP+M + +++ +I +L E K +++ +++T ED+ + Sbjct: 1 MEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRIL 60 Query: 279 KYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATG 338 + E+E ++ + I + ++ I + G D A H L++ N+ A+R V + IA A G Sbjct: 61 QMEEEYIHQLCEDIIQLKPDVVITEKGISDLAQHYLMRANVTAIRRVRKTDNNRIARACG 120 Query: 339 GRIVPRFSELTAEKLGF-AGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGN 391 RIV R EL + +G AGL++ G + I CK+ +A TI +RG + Sbjct: 121 ARIVSRPEELREDDVGTGAGLLEIKKIG--DEYFTFITDCKDPKACTILLRGAS 172 >4V4O-A nrPDB Length = 543 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 82/330 (24%), Positives = 150/330 (45%), Gaps = 62/330 (18%) Query: 43 AVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQI----AKLMVELSKSQ 98 AVAN ++ +LGP G + ++ K G T+T DG T+ ++++ + A+L+ E++ Sbjct: 21 AVANAVKVTLGPRGRNVVLEKKFGSPTITKDGVTVAKEVELEDHLENIGAQLLKEVASKT 80 Query: 99 DDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVD 158 +D GDGTT VLA A++ E + + G +P+ + G E+A A+E + ++ + Sbjct: 81 NDVAGDGTTTATVLAQAIVREGLKNVAAGANPLALKRGIEKAVEAAVEKIKALA----IP 136 Query: 159 IKDTEPLIQTAKTTLGSKVVNSC-HRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGG 217 ++D + + + A + V M ++ ++TV E + ++ EL VEG Sbjct: 137 VEDRKAIEEVATISANDPEVGKLIADAMEKVGKEGIITVE--ESKSLETELKFVEG---- 190 Query: 218 RLEDTKLIKGVIVDKDFSHPQ-MPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKA 276 + KG I ++P+ M +EDA I I+ + V++V + Sbjct: 191 ----YQFDKGYISPYFVTNPETMEAVLEDAFILIV-------------EKKVSNVRELLP 233 Query: 277 LQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLP---AVRWVGGPE---- 329 + ++Q+ +TG L I + EA L+ N L +V V P Sbjct: 234 I-----------LEQVAQTGKPLLIIAEDVEGEALATLVVNKLRGTLSVAAVKAPGFGDR 282 Query: 330 ----IELIAIATGGRIVPRFSELTAEKLGF 355 ++ IA TGG ++ +E+LGF Sbjct: 283 RKEMLKDIAAVTGGTVI-------SEELGF 305 >4AAR-A nrPDB Length = 548 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 52/219 (23%), Positives = 101/219 (46%), Gaps = 29/219 (13%) Query: 44 VANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQI----AKLMVELSKSQD 99 +A+ ++ +LGP G + ++ G T+T DG ++ ++++ + A+++ E++ + Sbjct: 23 LADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASKAN 82 Query: 100 DEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDI 159 D GDGTT VLA A++ E + + G++P+ + G ++A A+E L +S V Sbjct: 83 DAAGDGTTTATVLAQAIITEGLKAVAAGMNPMDLKRGIDKAVTAAVEELKALS----VPC 138 Query: 160 KDTEPLIQTAKTTLGS--KVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGG 217 D++ + Q + S V M ++ V+TV D G Sbjct: 139 SDSKAIAQVGTISANSDETVGKLIAEAMDKVGKEGVITVED-----------------GT 181 Query: 218 RLEDT-KLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPF 255 L+D +++G+ D+ + P K E + L PF Sbjct: 182 GLQDELDVVEGMQFDRGYLSPYFINKPETGAVE-LESPF 219 >4PJ1-A nrPDB Length = 558 Score = 54.7 bits (130), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 47/188 (25%), Positives = 87/188 (46%), Gaps = 10/188 (5%) Query: 29 MGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQI- 87 G +A + +A+ + ++GP G ++ G VT DG T+ +D+ + Sbjct: 34 FGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYK 93 Query: 88 ---AKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVA 144 AKL+ +++ + ++E GDGTT VLA ++ +E + + +G +P+ I G A Sbjct: 94 NIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAV 153 Query: 145 IEHLDKISDSVLVDIKDTEPLIQTAKTTLGS--KVVNSCHRQMAEIAVNAVLTVADMERR 202 I L K S V E + Q A + ++ N M ++ V+TV D + Sbjct: 154 IAELKKQSKPVTT----PEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTL 209 Query: 203 DVDFELIK 210 + + E+I+ Sbjct: 210 NDELEIIE 217 >1SJP-A nrPDB Length = 504 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 82/343 (23%), Positives = 144/343 (41%), Gaps = 71/343 (20%) Query: 66 GDVTVTNDGATILSMMDVDHQI----AKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAE 121 G T+TNDG +I ++++ A+L+ E++K DD GDGTT VLA AL+ E Sbjct: 2 GAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGL 61 Query: 122 QLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSC 181 + + G +P+ + G E+A ++K+++++L K+ E Q A T S S Sbjct: 62 RNVAAGANPLGLKRGIEKA-------VEKVTETLLKGAKEVETKEQIAATAAISAGDQSI 114 Query: 182 HRQMAE----IAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHP 237 +AE + V+TV + + EL E + KG I + P Sbjct: 115 GDLIAEAMDKVGNEGVITVEESNTFGLQLELT----------EGMRFDKGYISGYFVTDP 164 Query: 238 QMPKKV-EDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKAL---------------QKYE 281 + + V ED I +++ V++V+D L + E Sbjct: 165 ERQEAVLEDPYILLVSS-------------KVSTVKDLLPLLEKVIGAGKPLLIIAEDVE 211 Query: 282 KEKFEEM-IQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGR 340 E + + +I+ T ++A+ GF D +LQ+ +AI TGG+ Sbjct: 212 GEALSTLVVNKIRGTFKSVAVKAPGFGDR-RKAMLQD---------------MAILTGGQ 255 Query: 341 IVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAV 383 ++ LT E + L + TKD+ ++E ++ A+ Sbjct: 256 VISEEVGLTLENADLSLLGKARKVVVTKDETTIVEGAGDTDAI 298 >5DA8-A nrPDB Length = 545 Score = 50.1 bits (118), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 80/354 (22%), Positives = 148/354 (41%), Gaps = 64/354 (18%) Query: 44 VANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATI---LSMMD-VDHQIAKLMVELSKSQD 99 +AN ++ +LGP G + ++ K G T T DG T+ + ++D V++ A+++ E++ Sbjct: 23 LANAVKVTLGPAGRNVLIDKKFGAPTSTKDGVTVAKEIELVDPVENMGAQMVREVASKTS 82 Query: 100 DEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDI 159 D GDGTT VLA A+ E + + G PI + G ++A + + L IS S+ Sbjct: 83 DVAGDGTTTATVLAQAIYREGLKNVTAGARPIDLKRGIDRAVKEVVAELRNISRSI--SG 140 Query: 160 KDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRL 219 K + T ++ M ++ + V+TV E + ++ EL Sbjct: 141 KKEIAQVGTISANNDPEIGELIAEAMDKVGKDGVITVE--EAKGMETEL----------- 187 Query: 220 EDTKLIKGVIVDKDFSHP-------QMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVE 272 K+++G+ D+ + P M ++++A I I H +++++ Sbjct: 188 ---KVVEGMQFDRGYLSPYFVTNSETMEAELDEALILI-------------HDKKISNMK 231 Query: 273 DYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNL------PAVRWVG 326 + ++++ ++G L I + EA L+ N L AV+ G Sbjct: 232 E-----------LLPILEKAAQSGRPLLIIAEDIEGEALATLVVNKLRGTLKVAAVKAPG 280 Query: 327 GPE-----IELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIE 375 + +E IAI TGG ++ E A L Q KD ++E Sbjct: 281 FGDRRKAMLEDIAILTGGTVISEEKGYKLENATMAYLGQAARITIDKDNTTIVE 334 >1IOK-A nrPDB Length = 545 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 38/176 (21%), Positives = 91/176 (51%), Gaps = 16/176 (9%) Query: 44 VANTMRTSLGPNGLDKMMVDKD-GDVTVTNDGATILSMMDVDHQI----AKLMVELSKSQ 98 +A+ ++ +LGP G + +++DK G +T DG ++ +++ + A+++ E++ Sbjct: 23 LADAVKVTLGPKGRN-VVIDKSFGAPRITKDGVSVAKEIELSDKFENMGAQMVREVASRT 81 Query: 99 DDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDK----ISDS 154 +DE GDGTT VLA A++ E + + G++P+ + G + A +E + ++DS Sbjct: 82 NDEAGDGTTTATVLAQAIVREGLKAVAAGMNPMDLKRGIDVATAKVVEAIKSAARPVNDS 141 Query: 155 VLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIK 210 ++ + ++ +G ++ + R + V+TV + + + + E+++ Sbjct: 142 --SEVAQVGTISANGESFIGQQIAEAMQR----VGNEGVITVEENKGMETEVEVVE 191 >5CDI-A nrPDB Length = 552 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 47/189 (24%), Positives = 94/189 (49%), Gaps = 12/189 (6%) Query: 31 LEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQI--- 87 ++ALK +A + ++GP G + ++ K G + NDG TI +++ + Sbjct: 11 MQALKRMQAGVDKLATVVGVTIGPKGRNVVLESKFGAPKIVNDGVTIAREVELSDPVENI 70 Query: 88 -AKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIE 146 A L+ + + +D GDGTT VL+ A + E +++ G +P+++ G E+ + ++ Sbjct: 71 GATLVRQAAARTNDTAGDGTTTATVLSAAFIAEGMKIVSAGTNPVQLVRGMEKTVQELVK 130 Query: 147 HLDKISDSVLV--DIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDV 204 L K+S V D+ + + T +GS + ++ MA++ V+T+ E + Sbjct: 131 ELRKMSSVVQTDKDLANVACVSAGGNTDIGSLISDA----MAKVGRTGVVTME--EGKTA 184 Query: 205 DFELIKVEG 213 + +L+ VEG Sbjct: 185 EDQLVFVEG 193 >3FIJ-A nrPDB Length = 254 Score = 32.3 bits (72), Expect = 0.51, Method: Compositional matrix adjust. Identities = 20/66 (30%), Positives = 34/66 (51%), Gaps = 6/66 (9%) Query: 126 RGIHPIRIADG---YEQAARV---AIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVN 179 RG+ + +A G Y+ ++V A++HL ++ + + D EP + AK K+VN Sbjct: 116 RGMQLVNVALGGTLYQDISQVETKALQHLQRVDEQLGSHTIDIEPTSELAKHHPNKKLVN 175 Query: 180 SCHRQM 185 S H Q Sbjct: 176 SLHHQF 181 >1Q1R-A nrPDB Length = 431 Score = 31.6 bits (70), Expect = 1.0, Method: Compositional matrix adjust. Identities = 23/53 (43%), Positives = 29/53 (54%), Gaps = 2/53 (3%) Query: 400 RSLHDALCVIRNLIRDNR-VVYGGGAAEISCALAVSQEADKCPTLEQYAMRAF 451 R+L DA C+ R LI DNR VV GGG + A A + +A+ TL A R Sbjct: 134 RTLEDAECIRRQLIADNRLVVIGGGYIGLEVA-ATAIKANMHVTLLDTAARVL 185 >3EXA-A nrPDB Length = 322 Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 27/109 (24%), Positives = 47/109 (43%), Gaps = 18/109 (16%) Query: 115 ALLEEAEQLLDRGIHPIRI--ADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTT 172 L++EA++L DRGI + A GY++ + D D ++ A T Sbjct: 219 GLIDEAKKLYDRGIRDCQSVQAIGYKE----------------MYDYLDGNVTLEEAIDT 262 Query: 173 LGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLED 221 L RQ+ A +T DM D D +++++ + G+LE+ Sbjct: 263 LKRNSRRYAKRQLTWFRNKANVTWFDMTDVDFDKKIMEIHNFIAGKLEE 311 >4FYP-A nrPDB Length = 263 Score = 30.0 bits (66), Expect = 3.0, Method: Compositional matrix adjust. Identities = 17/51 (33%), Positives = 28/51 (54%), Gaps = 4/51 (7%) Query: 101 EIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKI 151 E G+ T G+ L E LL+ GI PI I+D +++ + V +E+L + Sbjct: 141 ESGESTPGL----PETLHLYENLLELGIEPIIISDRWKKLSEVTVENLKAV 187 >2VLD-A nrPDB Length = 251 Score = 29.6 bits (65), Expect = 3.7, Method: Compositional matrix adjust. Identities = 22/70 (31%), Positives = 34/70 (48%), Gaps = 6/70 (8%) Query: 57 LDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGAL 116 +D M VDKDG++ V L D M S +E G+ G++V A +L Sbjct: 159 VDVMGVDKDGNIVVLE-----LKRRKADLHAVSQMKRYVDSLKEEYGENVRGILV-APSL 212 Query: 117 LEEAEQLLDR 126 E A++LL++ Sbjct: 213 TEGAKKLLEK 222 >1RLU-A nrPDB Length = 382 Score = 29.3 bits (64), Expect = 4.7, Method: Compositional matrix adjust. Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 9/89 (10%) Query: 121 EQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVL------VDIKDTEPLIQTAKTTL- 173 ++LL G + + D + A V + + I+D + VD D + ++ A T L Sbjct: 167 DRLLQMGDAAVSLMDAFRSADEVLLNGVQGITDLITTPGLINVDFADVKGIMSGAGTALM 226 Query: 174 --GSKVVNSCHRQMAEIAVNAVLTVADME 200 GS + AEIA+N+ L A ME Sbjct: 227 GIGSARGEGRSLKAAEIAINSPLLEASME 255 >4RUN-A nrPDB Length = 161 Score = 28.9 bits (63), Expect = 5.7, Method: Composition-based stats. Identities = 12/30 (40%), Positives = 18/30 (60%) Query: 222 TKLIKGVIVDKDFSHPQMPKKVEDAKIAIL 251 T +K ++VDKDF + P+KV K+ L Sbjct: 13 TWYVKAMVVDKDFPEDRRPRKVSPVKVTAL 42 >3JVD-A nrPDB Length = 333 Score = 28.9 bits (63), Expect = 6.3, Method: Compositional matrix adjust. Identities = 43/185 (23%), Positives = 72/185 (38%), Gaps = 41/185 (22%) Query: 232 KDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQ 291 K + PQ +KV+ A + P + K +H+ + V +Y E + + Q Sbjct: 30 KGYVSPQTREKVQAAAKELNYVPNQLAKALREHRSALVGVIVPDLSNEYYSESLQTIQQD 89 Query: 292 IKETGANLAICQWGFDDEANHLLLQN---------------NLPAVRWVGGPEIELIAIA 336 +K G + + EAN + Q+ ++P V + I ++ + Sbjct: 90 LKAAGYQMLVA------EANSVQAQDVVMESLISIQAAGIIHVPVVGSIAPEGIPMVQLT 143 Query: 337 TG--GRIVPR--------FSELTAEKLGFAG-----LVQEISFGTTKDKMLVIEQCKNSR 381 G G PR F +LT LG +G LV E S TT+++M I S Sbjct: 144 RGELGPGFPRVLCDDEAGFFQLTESVLGGSGMNIAALVGEESLSTTQERMRGI-----SH 198 Query: 382 AVTIF 386 A +I+ Sbjct: 199 AASIY 203 >4BT6-A nrPDB Length = 257 Score = 28.5 bits (62), Expect = 8.3, Method: Compositional matrix adjust. Identities = 19/49 (38%), Positives = 26/49 (53%), Gaps = 7/49 (14%) Query: 251 LTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFE--EMIQQIKETGA 297 +T FEP K K +T+V+DY L K +EKFE + +K TG Sbjct: 95 VTTHFEP-----KEKTTLTNVQDYNQLTKMLEEKFENKNVFYAVKLTGT 138 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5UYZ-A nrPDB 695 0.0 4XCG-B nrPDB 635 0.0 3J1E-A nrPDB 635 0.0 4V8R-AE nrPDB 632 0.0 1Q3S-A nrPDB 611 e-175 3J1C-A nrPDB 602 e-172 1A6E-A nrPDB 600 e-172 3RUW-A nrPDB 593 e-170 4XCI-A nrPDB 591 e-169 1A6D-B nrPDB 591 e-169 4B2T-G nrPDB 589 e-168 4B2T-H nrPDB 572 e-163 3IYF-A nrPDB 566 e-162 5GW5-g nrPDB 554 e-158 5GW4-h nrPDB 552 e-157 4B2T-D nrPDB 543 e-155 3AQ1-B nrPDB 541 e-154 4B2T-A nrPDB 538 e-153 4V8R-AG nrPDB 529 e-150 4V94-A nrPDB 514 e-146 5GW4-d nrPDB 506 e-144 4B2T-Z nrPDB 504 e-143 4B2T-Q nrPDB 496 e-140 5GW5-z nrPDB 496 e-140 4B2T-B nrPDB 494 e-140 4V8R-AB nrPDB 490 e-139 5GW5-q nrPDB 485 e-137 5X9V-A nrPDB 421 e-118 4V4O-A nrPDB 264 5e-71 1IOK-A nrPDB 239 3e-63 4AAR-A nrPDB 238 5e-63 5DA8-A nrPDB 236 3e-62 4PJ1-A nrPDB 225 3e-59 1SJP-A nrPDB 224 8e-59 5CDI-A nrPDB 207 1e-53 1GN1-A nrPDB 190 2e-48 1E0R-B nrPDB 170 1e-42 1ASS-A nrPDB 170 2e-42 Sequences not found previously or not previously below threshold: 1SRV-A nrPDB 68 1e-11 1KID-A nrPDB 66 4e-11 1DKD-A nrPDB 62 6e-10 3OSX-A nrPDB 59 5e-09 3M6C-A nrPDB 53 4e-07 5CDK-A nrPDB 48 7e-06 3LXD-A nrPDB 40 0.003 5CDJ-A nrPDB 39 0.005 3E0V-A nrPDB 36 0.047 4G1T-A nrPDB 34 0.15 3L6X-A nrPDB 33 0.29 6ESQ-A nrPDB 33 0.31 3BWN-A nrPDB 33 0.37 5H12-A nrPDB 32 0.53 4FLV-A nrPDB 31 0.89 4UZY-A nrPDB 31 1.4 1FX7-A nrPDB 31 1.5 3D31-A nrPDB 31 1.7 2H6E-A nrPDB 30 2.0 4KRZ-A nrPDB 30 2.4 2GJN-A nrPDB 30 2.6 2VWK-A nrPDB 30 2.7 1S5J-A nrPDB 30 3.9 2OF3-A nrPDB 30 4.0 2GF2-A nrPDB 30 4.0 1V72-A nrPDB 29 4.9 5U7X-F nrPDB 29 5.6 4XFK-A nrPDB 29 6.4 2QS8-A nrPDB 28 8.6 1Q1R-A nrPDB 28 8.9 3GEE-A nrPDB 28 9.6 >5UYZ-A nrPDB Length = 541 Score = 695 bits (1795), Expect = 0.0, Method: Composition-based stats. Identities = 540/541 (99%), Positives = 540/541 (99%) Query: 1 MASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKM 60 MASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKM Sbjct: 1 MASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKM 60 Query: 61 MVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEA 120 MVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEA Sbjct: 61 MVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEA 120 Query: 121 EQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNS 180 EQLLDRGIHPIRIADGYEQAARVAIE LDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNS Sbjct: 121 EQLLDRGIHPIRIADGYEQAARVAIERLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNS 180 Query: 181 CHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMP 240 CHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMP Sbjct: 181 CHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMP 240 Query: 241 KKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLA 300 KKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLA Sbjct: 241 KKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLA 300 Query: 301 ICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQ 360 ICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQ Sbjct: 301 ICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQ 360 Query: 361 EISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVY 420 EISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVY Sbjct: 361 EISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVY 420 Query: 421 GGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRAR 480 GGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRAR Sbjct: 421 GGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRAR 480 Query: 481 QVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESE 540 QVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESE Sbjct: 481 QVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESE 540 Query: 541 E 541 E Sbjct: 541 E 541 >4XCG-B nrPDB Length = 557 Score = 635 bits (1638), Expect = 0.0, Method: Composition-based stats. Identities = 208/538 (38%), Positives = 332/538 (61%), Gaps = 8/538 (1%) Query: 3 SMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMV 62 + T+A G P +I+K+ SR G EAL+++I A KA+ ++++ GP G+DKM+V Sbjct: 5 ATATVATTPEGIPVIILKEG--SSRTYGKEALRANIAAVKAIEEALKSTYGPRGMDKMLV 62 Query: 63 DKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQ 122 D GD+T+TNDGATIL MD+ H KL+V+++K QD+E DGT V+LAG L ++AE Sbjct: 63 DSLGDITITNDGATILDKMDLQHPTGKLLVQIAKGQDEETADGTKTAVILAGELAKKAED 122 Query: 123 LLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCH 182 LL + IHP I GY++A +A++ + +I+ V ++ DT+ L + A T+LGSK V Sbjct: 123 LLYKEIHPTIIVSGYKKAEEIALKTIQEIAQPVTIN--DTDVLRKVALTSLGSKAVAGAR 180 Query: 183 RQMAEIAVNAVLTVADM--ERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMP 240 +A++ V AV VA++ ++ VD + +++ K GG + DT+L+ G++VDK+ HP MP Sbjct: 181 EYLADLVVKAVAQVAELRGDKWYVDLDNVQIVKKHGGSVNDTQLVYGIVVDKEVVHPGMP 240 Query: 241 KKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLA 300 K++E+AKIA+L E KP+ ++ + + E+ +E + +I TGAN+ Sbjct: 241 KRIENAKIALLDASLEVEKPELDAEIRINDPTQMHKFLEEEENILKEKVDKIAATGANVV 300 Query: 301 ICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQ 360 ICQ G D+ A H L + + AVR ++E +A ATGGR++ ELT++ LG+A LV+ Sbjct: 301 ICQKGIDEVAQHYLAKKGILAVRRAKKSDLEKLARATGGRVISNIDELTSQDLGYAALVE 360 Query: 361 EISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVY 420 E G +DKM+ +E KN ++V+I IRGG + +++E +R+L DAL + ++IRD R V Sbjct: 361 ERKVG--EDKMVFVEGAKNPKSVSILIRGGLERVVDETERALRDALGTVADVIRDGRAVA 418 Query: 421 GGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRAR 480 GGGA EI A + + A + EQ A+ A+A+A+E + M L+EN+G++PI + ++R+ Sbjct: 419 GGGAVEIEIAKRLRKYAPQVGGKEQLAIEAYANAIEGLIMILAENAGLDPIDKLMQLRSL 478 Query: 481 QVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGE 538 E N G++ DM + VIE + K + AT+ V ++L+IDDI G+ Sbjct: 479 HENETNKWYGLNLFTGNPEDMWKLGVIEPALVKMNAVKAATEAVTLVLRIDDIVAAGK 536 >3J1E-A nrPDB Length = 553 Score = 635 bits (1637), Expect = 0.0, Method: Composition-based stats. Identities = 205/540 (37%), Positives = 330/540 (61%), Gaps = 8/540 (1%) Query: 1 MASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKM 60 MAS T+A G P +I+K+ SR G EA++++I A KAV ++++ GP G+DKM Sbjct: 1 MASTATVATTPEGIPVIILKEG--SSRTYGKEAVRANIAAVKAVEEALKSTYGPRGMDKM 58 Query: 61 MVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEA 120 +VD GD+T+TNDGATIL MD+ H AKL+V+++K QD+E DGT V+ +G L+++A Sbjct: 59 LVDSLGDITITNDGATILDKMDLQHPAAKLLVQIAKGQDEETADGTKTAVIFSGELVKKA 118 Query: 121 EQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNS 180 E LL + +HP I GY++A VA++ + +++ +V ++ DT+ L + A T+L SK V Sbjct: 119 EDLLYKDVHPTIIISGYKKAEEVALQTIQELAQTVSIN--DTDLLRKIAMTSLSSKAVAG 176 Query: 181 CHRQMAEIAVNAVLTVADM--ERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQ 238 +A+I V AV VA++ ++ VD + I++ K GG + DT+L+ G++VDK+ HP Sbjct: 177 AREYIADIVVKAVTQVAELRGDKWYVDLDNIQIVKKAGGSINDTQLVYGIVVDKEVVHPG 236 Query: 239 MPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGAN 298 MPK++E+AKIA++ E KP+ ++ + + E+ +E + +I TGAN Sbjct: 237 MPKRLENAKIALIDASLEVEKPELDAEIRINDPTQMQKFLDEEENLIKEKVDKILATGAN 296 Query: 299 LAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGL 358 + ICQ G D+ A L + + AVR ++E +A ATGGR+V E++ + LG+A L Sbjct: 297 VIICQKGIDEVAQSYLAKKGVLAVRRAKKSDLEKLARATGGRVVSNIDEISEQDLGYASL 356 Query: 359 VQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRV 418 ++E G +DKM+ +E KN ++++I IRGG + +++E +R+L DAL + ++I+D R Sbjct: 357 IEERKVG--EDKMVFVEGAKNPKSISILIRGGLERLVDETERALRDALGTVADVIKDGRA 414 Query: 419 VYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVR 478 + GGGA EI A + + A + EQ A+ A+A+ALE + L EN+G +PI + ++R Sbjct: 415 IAGGGAVEIEIAKKLRKYAPQVGGKEQLAVEAYANALESLVSILIENAGFDPIDLLMKLR 474 Query: 479 ARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGE 538 + E N GID DM Q+ VIE + K I AT+ ++L+IDD+ G+ Sbjct: 475 STHENENNKWYGIDLYAGQPVDMWQKGVIEPALVKMNAIKAATEAATLVLRIDDVVSAGK 534 >4V8R-AE nrPDB Length = 562 Score = 632 bits (1630), Expect = 0.0, Method: Composition-based stats. Identities = 326/546 (59%), Positives = 442/546 (80%), Gaps = 8/546 (1%) Query: 3 SMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMV 62 S +A DE GRPF+I+KDQ K R GLEA KSHI+AA++VA+ ++TSLGP GLDK+++ Sbjct: 16 SNAIVAQDEMGRPFIIVKDQGNKKRQHGLEAKKSHILAARSVASIIKTSLGPRGLDKILI 75 Query: 63 DKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQ 122 DG++T+TNDGATILS M++D++IAKL+V+LSKSQDDEIGDGTTGVVVLA ALL++A + Sbjct: 76 SPDGEITITNDGATILSQMELDNEIAKLLVQLSKSQDDEIGDGTTGVVVLASALLDQALE 135 Query: 123 LLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKD--TEPLIQTAKTTLGSKVVNS 180 L+ +GIHPI+IA+G+++AA++AI L++ D + + + L++ AKT+LGSK+V+ Sbjct: 136 LIQKGIHPIKIANGFDEAAKLAISKLEETCDDISASNDELFRDFLLRAAKTSLGSKIVSK 195 Query: 181 CHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMP 240 H + AE+AV AV+ V D +R+DVDF+LIK++G+VGG + D+KLI GVI+DKDFSHPQMP Sbjct: 196 DHDRFAEMAVEAVINVMDKDRKDVDFDLIKMQGRVGGSISDSKLINGVILDKDFSHPQMP 255 Query: 241 KKV------EDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKE 294 K V + K+AILTCPFEPPKPKTKHKLD++SVE+Y+ LQ YE++KF+EMI +K+ Sbjct: 256 KCVLPKEGSDGVKLAILTCPFEPPKPKTKHKLDISSVEEYQKLQTYEQDKFKEMIDDVKK 315 Query: 295 TGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLG 354 GA++ ICQWGFDDEANHLLLQN+LPAVRWVGG E+E IAI+T GRIVPRF +L+ +KLG Sbjct: 316 AGADVVICQWGFDDEANHLLLQNDLPAVRWVGGQELEHIAISTNGRIVPRFQDLSKDKLG 375 Query: 355 FAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIR 414 + E FGTTKD+ML+IEQ K ++ VT F+RG NKMI++EA+R+LHD+LCV+RNL++ Sbjct: 376 TCSRIYEQEFGTTKDRMLIIEQSKETKTVTCFVRGSNKMIVDEAERALHDSLCVVRNLVK 435 Query: 415 DNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTM 474 D+RVVYGGGAAE++ +LAVS+EADK ++QYA R FA AL+ IPM L+ENSG++PI T+ Sbjct: 436 DSRVVYGGGAAEVTMSLAVSEEADKQRGIDQYAFRGFAQALDTIPMTLAENSGLDPIGTL 495 Query: 475 TEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIR 534 + ++++Q+KE +G+DCL G+NDMK+ V++ IGKKQQI LATQ+ RMILKID++ Sbjct: 496 STLKSKQLKEKISNIGVDCLGYGSNDMKELFVVDPFIGKKQQILLATQLCRMILKIDNVI 555 Query: 535 KPGESE 540 G+ E Sbjct: 556 ISGKDE 561 >1Q3S-A nrPDB Length = 548 Score = 611 bits (1577), Expect = e-175, Method: Composition-based stats. Identities = 214/526 (40%), Positives = 333/526 (63%), Gaps = 9/526 (1%) Query: 13 GRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTN 72 G+P +I+ + + R +G +A + +I+AA+ +A T+RT+LGP G+DKM+VD GD+ VTN Sbjct: 6 GQPVVILPEGTQ--RYVGRDAQRLNILAARIIAETVRTTLGPKGMDKMLVDSLGDIVVTN 63 Query: 73 DGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIR 132 D ATIL +D+ H AK+MVE++K+QD E GDGTT VV+AG LL +AE+LLD+ IHP Sbjct: 64 DCATILDKIDLQHPAAKMMVEVAKTQDKEAGDGTTTAVVIAGELLRKAEELLDQNIHPSI 123 Query: 133 IADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNA 192 I GY AA A E LD+I+ + VD D E L++ A T++ K S +A++AV A Sbjct: 124 IIKGYALAAEKAQEILDEIA--IRVDPDDEETLLKIAATSITGKNAESHKELLAKLAVEA 181 Query: 193 VLTVADME--RRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAI 250 V VA+ + + VD + IK E K G +E+++L++GV++DK+ HP+MPK+VE+AKIA+ Sbjct: 182 VKQVAEKKDGKYVVDLDNIKFEKKAGEGVEESELVRGVVIDKEVVHPRMPKRVENAKIAL 241 Query: 251 LTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEA 310 + E K +T K+++TS + + + E++ ++M+ I +TGAN+ Q G DD A Sbjct: 242 INEALEVKKTETDAKINITSPDQLMSFLEQEEKMLKDMVDHIAQTGANVVFVQKGIDDLA 301 Query: 311 NHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDK 370 H L + + AVR V ++E +A ATG +IV +LT E LG+A +V+E + Sbjct: 302 QHYLAKYGIMAVRRVKKSDMEKLAKATGAKIVTNVKDLTPEDLGYAEVVEERKLAG--EN 359 Query: 371 MLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCA 430 M+ +E CKN +AVTI IRGG + +I+E +R+L DA+ V+++++ D V+ GGA EI A Sbjct: 360 MIFVEGCKNPKAVTILIRGGTEHVIDEVERALEDAVKVVKDVMEDGAVLPAGGAPEIELA 419 Query: 431 LAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALG 490 + + + A + E A+ FADAL++IP L+EN+G++ ++ + +V + K +G Sbjct: 420 IRLDEYAKQVGGKEALAIENFADALKIIPKTLAENAGLDTVEMLVKVISEH-KNRGLGIG 478 Query: 491 IDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKP 536 ID DM ++ +IE L KKQ I A++ MIL+IDD+ Sbjct: 479 IDVFEGKPADMLEKGIIEPLRVKKQAIKSASEAAIMILRIDDVIAA 524 >3J1C-A nrPDB Length = 563 Score = 602 bits (1553), Expect = e-172, Method: Composition-based stats. Identities = 213/536 (39%), Positives = 330/536 (61%), Gaps = 15/536 (2%) Query: 13 GRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTN 72 G P L+ K+ SR G +ALK++I+AA+ +A +R+SLGP GLDKM++D GDVT+TN Sbjct: 4 GVPVLLFKEGT--SRNSGRDALKNNILAARTLAEMLRSSLGPKGLDKMLIDSFGDVTITN 61 Query: 73 DGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIR 132 DGATI+ M++ H AKL+VE +K+QD E+GDGTT VVLAG LE+AE L+D+ IHP Sbjct: 62 DGATIVKEMEIQHPAAKLLVEAAKAQDSEVGDGTTSAVVLAGLFLEKAESLVDQNIHPTI 121 Query: 133 IADGYEQAARVAIEHLDKISDSVLVDIKD----TEPLIQTAKTTLGSKVVNSCHR--QMA 186 I +G+++A ++E L +++ V V + + L + TT+ SK + ++ Sbjct: 122 IIEGFKKAFNKSLELLPQLATKVDVSDLNSATARDALKKIVYTTMSSKFMAEGEELNKIM 181 Query: 187 EIAVNAVLTVAD---MERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKV 243 +I ++AV TVA+ +V +LIK++ K GG +ED++LI+G+++DK+ H MP++V Sbjct: 182 DIVIDAVTTVAEPLPDGGYNVSLDLIKIDKKKGGTIEDSQLIRGIVLDKEVVHAGMPRRV 241 Query: 244 EDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQ 303 E AKIA+L E KP+ K+ +TS + KA E + ++M+ ++ GAN+ ICQ Sbjct: 242 EKAKIAVLDASLEVEKPEISAKISITSPDQIKAFLDEEAKYLKDMVDKLASIGANVVICQ 301 Query: 304 WGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEIS 363 G DD A H L + + AVR V +IE + A G RI+ + T E LG+A LV+E Sbjct: 302 KGIDDIAQHFLAKRGILAVRRVKRSDIEKLEKALGARIISSIKDATPEDLGYAELVEERK 361 Query: 364 FGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGG 423 G DKM+ IE KN +AV I +RG N M ++EA+RS++DAL +RN++ + +V GGG Sbjct: 362 VGN--DKMVFIEGAKNPKAVNILLRGSNDMALDEAERSINDALYSLRNILMEPYIVPGGG 419 Query: 424 AAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVK 483 A E+ + + + A EQ A+ A+ADALE IPM L+E +G+ PI + ++RAR K Sbjct: 420 AIELELSARLREYARSVGGKEQLAIEAYADALEEIPMILAETAGLEPISALMDLRARHAK 479 Query: 484 EMNPALGIDCLHKG-TNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGE 538 + G+D ++ +D+ +V+E + +Q + AT+ I+KIDD+ + Sbjct: 480 GLTNC-GVDVINGKIIDDIYSINVVEPIRVTRQVLKSATEAATSIMKIDDLIAASQ 534 >1A6E-A nrPDB Length = 545 Score = 600 bits (1546), Expect = e-172, Method: Composition-based stats. Identities = 205/528 (38%), Positives = 323/528 (61%), Gaps = 11/528 (2%) Query: 14 RPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTND 73 P L++K+ + R G A +++I AAKA+A+ +RT+LGP G+DKM+VD GD+ ++ND Sbjct: 6 VPILVLKEGTQ--REQGKNAQRNNIEAAKAIADAVRTTLGPKGMDKMLVDSIGDIIISND 63 Query: 74 GATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRI 133 GATIL MDV+H AK++VE+SK+QD +GDGTT VVL+G LL++AE LLD+G+HP I Sbjct: 64 GATILKEMDVEHPTAKMIVEVSKAQDTAVGDGTTTAVVLSGELLKQAETLLDQGVHPTVI 123 Query: 134 ADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAV 193 ++GY A A + +D+I++ D L + A T L K + +A++ V AV Sbjct: 124 SNGYRLAVNEARKIIDEIAEKST----DDATLRKIALTALSGKNTGLSNDFLADLVVKAV 179 Query: 194 LTVAD--MERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAIL 251 VA+ + VD IKV+ K GG + DT+ I G+++DK+ H +MP V++AKIA++ Sbjct: 180 NAVAEVRDGKTIVDTANIKVDKKNGGSVNDTQFISGIVIDKEKVHSKMPDVVKNAKIALI 239 Query: 252 TCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEAN 311 E K + + K+ ++ + E F++M+++IK++GAN+ +CQ G DD A Sbjct: 240 DSALEIKKTEIEAKVQISDPSKIQDFLNQETNTFKQMVEKIKKSGANVVLCQKGIDDVAQ 299 Query: 312 HLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKM 371 H L + + AVR V ++E +A ATG +IV +LT LG A V+E G D+M Sbjct: 300 HYLAKEGIYAVRRVKKSDMEKLAKATGAKIVTDLDDLTPSVLGEAETVEERKIG--DDRM 357 Query: 372 LVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCAL 431 + CKN +AV+I IRGG ++ E +R+L+DA+ V+ D + ++GGGA E A+ Sbjct: 358 TFVMGCKNPKAVSILIRGGTDHVVSEVERALNDAIRVVAITKEDGKFLWGGGAVEAELAM 417 Query: 432 AVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGI 491 +++ A+ EQ A+ AFA ALE+IP L+EN+G++PI T+ +++A K ++G+ Sbjct: 418 RLAKYANSVGGREQLAIEAFAKALEIIPRTLAENAGIDPINTLIKLKADDEKGR-ISVGV 476 Query: 492 DCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGES 539 D + G DMK + V++ L K + A ++ MIL+IDD+ +S Sbjct: 477 DLDNNGVGDMKAKGVVDPLRVKTHALESAVEVATMILRIDDVIASKKS 524 >3RUW-A nrPDB Length = 543 Score = 593 bits (1530), Expect = e-170, Method: Composition-based stats. Identities = 211/515 (40%), Positives = 318/515 (61%), Gaps = 5/515 (0%) Query: 24 RKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDV 83 R MG +A + +I+A + +A T+R++LGP G+DKM+VD GDV VTNDG TIL M V Sbjct: 11 NMKRYMGRDAQRMNILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVVTNDGVTILREMSV 70 Query: 84 DHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARV 143 +H AK+++E++K+Q+ E+GDGTT VV+AG LL +AE+LLD+ +HP + GY+ AA+ Sbjct: 71 EHPAAKMLIEVAKTQEKEVGDGTTTAVVVAGELLRKAEELLDQNVHPTIVVKGYQAAAQK 130 Query: 144 AIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRD 203 A E L I+ V +D E L + A T++ K ++AEI V AV V D E + Sbjct: 131 AQELLKTIAC--EVGAQDKEILTKIAMTSITGKGAEKAKEKLAEIIVEAVSAVVDDEGK- 187 Query: 204 VDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTK 263 VD +LIK+E K G ++DT+LIKGV+VDK+ QMPKKV DAKIA+L C E + +T Sbjct: 188 VDKDLIKIEKKSGASIDDTELIKGVLVDKERVSAQMPKKVTDAKIALLNCAIEIKETETD 247 Query: 264 HKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVR 323 ++ +T + E++ ++M+ +IK +GAN+ CQ G DD A H L + + A R Sbjct: 248 AEIRITDPAKLMEFIEQEEKMLKDMVAEIKASGANVLFCQKGIDDLAQHYLAKEGIVAAR 307 Query: 324 WVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAV 383 V ++E +A ATG ++ + L+A+ LG AGLV+E + D M+ +E+CK+ +AV Sbjct: 308 RVKKSDMEKLAKATGANVIAAIAALSAQDLGDAGLVEERKI--SGDSMIFVEECKHPKAV 365 Query: 384 TIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTL 443 T+ IRG + +IEE R++ DA+ V+ I D R+V GGG+ E+ ++ + + A+ Sbjct: 366 TMLIRGTTEHVIEEVARAVDDAVGVVGCTIEDGRIVSGGGSTEVELSMKLREYAEGISGR 425 Query: 444 EQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQ 503 EQ A+RAFADALEVIP L+EN+G++ I+ + +VRA N G++ DM + Sbjct: 426 EQLAVRAFADALEVIPRTLAENAGLDAIEILVKVRAAHASNGNKCAGLNVFTGAVEDMCE 485 Query: 504 QHVIETLIGKKQQISLATQMVRMILKIDDIRKPGE 538 V+E L K Q I A + M+L+IDD+ + Sbjct: 486 NGVVEPLRVKTQAIQSAAESTEMLLRIDDVIAAEK 520 >4XCI-A nrPDB Length = 559 Score = 591 bits (1523), Expect = e-169, Method: Composition-based stats. Identities = 216/535 (40%), Positives = 331/535 (61%), Gaps = 15/535 (2%) Query: 12 YGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVT 71 P L++K+ SR G +AL+++I+AAK +A +R+SLGP GLDKM++D GDVT+T Sbjct: 1 MAAPVLLLKEGT--SRTTGRDALRNNILAAKTLAEMLRSSLGPKGLDKMLIDSFGDVTIT 58 Query: 72 NDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPI 131 NDGATI+ M++ H AKL+VE +K+QD E+GDGTT VVLAGALLE+AE LLD+ IHP Sbjct: 59 NDGATIVKDMEIQHPAAKLLVEAAKAQDAEVGDGTTSAVVLAGALLEKAESLLDQNIHPT 118 Query: 132 RIADGYEQAARVAIEHLDKISDSVLVDIKD----TEPLIQTAKTTLGSKVVNSCHR--QM 185 I +GY++A A+E L ++ + + + + L + A TTL SK + ++ Sbjct: 119 IIIEGYKKAYNKALELLPQLGTRIDIKDLNSSVARDTLRKIAFTTLASKFIAEGAELNKI 178 Query: 186 AEIAVNAVLTVAD---MERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKK 242 ++ ++A++ VA+ +V +LIK++ K GG +ED+ L+KG+++DK+ HP MP++ Sbjct: 179 IDMVIDAIVNVAEPLPNGGYNVSLDLIKIDKKKGGSIEDSVLVKGLVLDKEVVHPGMPRR 238 Query: 243 VEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAIC 302 V AKIA+L E KP+ K+ +TS E KA E + ++M+ ++ GAN+ IC Sbjct: 239 VTKAKIAVLDAALEVEKPEISAKISITSPEQIKAFLDEESKYLKDMVDKLASIGANVVIC 298 Query: 303 QWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEI 362 Q G DD A H L + + AVR V +IE + A G RI+ + T E LG+A LV+E Sbjct: 299 QKGIDDIAQHFLAKKGILAVRRVKRSDIEKLEKALGARIISSIKDATPEDLGYAELVEER 358 Query: 363 SFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGG 422 G DKM+ IE KN +AV I +RG N M ++EA+RS++DAL +RN++ + ++ GG Sbjct: 359 RVGN--DKMVFIEGAKNLKAVNILLRGSNDMALDEAERSINDALHALRNILLEPVILPGG 416 Query: 423 GAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQV 482 GA E+ A+ + + A EQ A+ AFADALE IP+ L+E +G+ I ++ ++RAR Sbjct: 417 GAIELELAMKLREYARSVGGKEQLAIEAFADALEEIPLILAETAGLEAISSLMDLRARHA 476 Query: 483 KEMNPALGIDCLHKGT-NDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKP 536 K ++ G+D + +D+ ++IE + K Q + AT+ ILKIDD+ Sbjct: 477 KGLSNT-GVDVIGGKIVDDVYALNIIEPIRVKSQVLKSATEAATAILKIDDLIAA 530 >1A6D-B nrPDB Length = 543 Score = 591 bits (1523), Expect = e-169, Method: Composition-based stats. Identities = 209/524 (39%), Positives = 318/524 (60%), Gaps = 9/524 (1%) Query: 13 GRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTN 72 G+P I+K+ + R G +A+K +I AA A++N++R+SLGP G+DKM+VD GD+ +TN Sbjct: 4 GQPIFILKEGTK--RESGKDAMKENIEAAIAISNSVRSSLGPRGMDKMLVDSLGDIVITN 61 Query: 73 DGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIR 132 DG TIL MDV+H AK+MVE+SK+QD +GDGTT V++AG LL++A+ L+++ +HP Sbjct: 62 DGVTILKEMDVEHPAAKMMVEVSKTQDSFVGDGTTTAVIIAGGLLQQAQGLINQNVHPTV 121 Query: 133 IADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNA 192 I++GY A+ A +D+IS + D + L++ A+T+L SK + ++AEI+ A Sbjct: 122 ISEGYRMASEEAKRVIDEISTKIGAD--EKALLLKMAQTSLNSKSASVAKDKLAEISYEA 179 Query: 193 VLTVADM--ERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAI 250 V +VA++ + VDF+ I+V K GG ++DT+LI G+IVDK+ HP MP V+DAKIA+ Sbjct: 180 VKSVAELRDGKYYVDFDNIQVVKKQGGAIDDTQLINGIIVDKEKVHPGMPDVVKDAKIAL 239 Query: 251 LTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEA 310 L P E KP+ L + + E+ EM+ +IK GAN+ I Q G DD A Sbjct: 240 LDAPLEIKKPEFDTNLRIEDPSMIQKFLAQEENMLREMVDKIKSVGANVVITQKGIDDMA 299 Query: 311 NHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDK 370 H L + + AVR V +++ +A ATG IV E+++ LG A V+++ G +D Sbjct: 300 QHYLSRAGIYAVRRVKKSDMDKLAKATGASIVSTIDEISSSDLGTAERVEQVKVG--EDY 357 Query: 371 MLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCA 430 M + CKN +AV+I +RG + +++E +RS+ D+L V+ + + D GGGA A Sbjct: 358 MTFVTGCKNPKAVSILVRGETEHVVDEMERSITDSLHVVASALEDGAYAAGGGATAAEIA 417 Query: 431 LAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALG 490 + A K +Q A+ FADA+E IP AL+EN+G++PI + ++RA K N G Sbjct: 418 FRLRSYAQKIGGRQQLAIEKFADAIEEIPRALAENAGLDPIDILLKLRAEHAKG-NKTYG 476 Query: 491 IDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIR 534 I+ DM + VIE + KQ I AT+ MIL+IDD+ Sbjct: 477 INVFTGEIEDMVKNGVIEPIRVGKQAIESATEAAIMILRIDDVI 520 >4B2T-G nrPDB Length = 545 Score = 589 bits (1518), Expect = e-168, Method: Composition-based stats. Identities = 178/531 (33%), Positives = 308/531 (58%), Gaps = 10/531 (1%) Query: 14 RPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTND 73 RP L++ + R G + +I AAK +A+ +RT LGP + KM++D G + +TND Sbjct: 5 RPVLVLSQNTK--RESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTND 62 Query: 74 GATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRI 133 G IL + V H AK M+E+S++QD+E+GDGTT V++LAG +L AE L++ +HP + Sbjct: 63 GNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVV 122 Query: 134 ADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAV 193 Y +A I L KIS + VD + + ++ +++ +KV++ IA++AV Sbjct: 123 ISAYRKALDDMISTLKKIS--IPVDTSNRDTMLNIINSSITTKVISRWSSLACNIALDAV 180 Query: 194 LTV--ADMERRDVDFE-LIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAI 250 TV + R+++D + +VE GG +ED+ +++GV+++KD +HP+M + +++ +I + Sbjct: 181 KTVQFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVL 240 Query: 251 LTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEA 310 L E K +++ +++T ED+ + + E+E +++ + I + ++ I + G D A Sbjct: 241 LDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLA 300 Query: 311 NHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGF-AGLVQEISFGTTKD 369 H L++ N+ A+R V + IA A G RIV R EL E +G AGL++ G + Sbjct: 301 QHYLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREEDVGTGAGLLEIKKIG--DE 358 Query: 370 KMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISC 429 I +CK+ +A TI +RG +K I+ E +R+L DA+ V RN++ D ++V GGGA+E++ Sbjct: 359 YFTFITECKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAV 418 Query: 430 ALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPAL 489 A A+++++ +EQ+ RA A ALEVIP L +N G + I+ +T +RA+ +E Sbjct: 419 AHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETW 478 Query: 490 GIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESE 540 G++ DMK+ + E L K Q A + ++L+IDDI + + Sbjct: 479 GVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKK 529 >4B2T-H nrPDB Length = 543 Score = 572 bits (1474), Expect = e-163, Method: Composition-based stats. Identities = 156/530 (29%), Positives = 286/530 (53%), Gaps = 14/530 (2%) Query: 15 PFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDG 74 P +++K+ S+ G+ L S+I A + +A +RT+LGP G+DK++VD G T++NDG Sbjct: 5 PVILLKEGTDSSQ--GIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDG 62 Query: 75 ATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIA 134 ATIL ++DV H AK +V+++KSQD E+GDGTT V +LA L++ + ++ G+HP I Sbjct: 63 ATILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIII 122 Query: 135 DGYEQAARVAIEHLDKISDSVLVD--IKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNA 192 + A ++A+ + +I+ +V + ++ + L + A T L SK+++ A++ V+A Sbjct: 123 RAFRTATQLAVNKIKEIAVTVKKEDKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDA 182 Query: 193 VLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQM---PKKVEDAKIA 249 V+ + D+ + ++I ++ GG LE+++L+ GV K FS+ PKK + IA Sbjct: 183 VMMLDDL----LQLKMIGIKKVQGGALEESQLVAGVAFKKTFSYAGFEMQPKKYHNPMIA 238 Query: 250 ILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDE 309 +L E K ++ V +VEDY+A+ E + +++I +GA + + + D Sbjct: 239 LLNVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGDV 298 Query: 310 ANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKD 369 A ++ V +++ +A GG I + L+++ LG + +E G + Sbjct: 299 ATQYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALSSDVLGRCQVFEETQIGGERY 358 Query: 370 KMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISC 429 C ++ TI +RGG + +EE +RSLHDA+ ++R I+++ VV GGGA E+ Sbjct: 359 NF--FTGCPKAKTCTIILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMEL 416 Query: 430 ALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPAL 489 + + + P +Q + A+A ALE+IP L +N+G + + ++RAR + Sbjct: 417 SKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGG-MWY 475 Query: 490 GIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGES 539 G+D + D + V E + + ++ A++ +I+ +D+ K S Sbjct: 476 GVDINTEDIADNFEAFVWEPAMVRINALTAASEAACLIVSVDETIKNPRS 525 >3IYF-A nrPDB Length = 521 Score = 566 bits (1459), Expect = e-162, Method: Composition-based stats. Identities = 209/515 (40%), Positives = 311/515 (60%), Gaps = 27/515 (5%) Query: 24 RKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDV 83 R MG +A + +I+A + +A T+R++LGP G+DKM+VD GDV VTNDG TIL M V Sbjct: 11 NMKRYMGRDAQRMNILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVVTNDGVTILREMSV 70 Query: 84 DHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARV 143 +H AK+++E++K+Q+ E+GDGTT VV+AG LL +AE+LLD+ +HP + GY+ AA+ Sbjct: 71 EHPAAKMLIEVAKTQEKEVGDGTTTAVVVAGELLRKAEELLDQNVHPTIVVKGYQAAAQK 130 Query: 144 AIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRD 203 A E L I+ V +D E L + A T++ K ++AEI V AV V D E + Sbjct: 131 AQELLKTIAC--EVGAQDKEILTKIAMTSITGKGAEKAKEKLAEIIVEAVSAVVDDEGK- 187 Query: 204 VDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTK 263 VD +LIK+E K G ++DT+LIKGV+VDK+ QMPKKV DAKIA+L C Sbjct: 188 VDKDLIKIEKKSGASIDDTELIKGVLVDKERVSAQMPKKVTDAKIALLNC---------- 237 Query: 264 HKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVR 323 A+++ E ++M+ +IK +GAN+ CQ G DD A H L + + A R Sbjct: 238 ------------AIEETASEMLKDMVAEIKASGANVLFCQKGIDDLAQHYLAKEGIVAAR 285 Query: 324 WVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAV 383 V ++E +A ATG ++ +L+A+ LG AGLV+E + D M+ +E+CK+ +AV Sbjct: 286 RVKKSDMEKLAKATGANVITNIKDLSAQDLGDAGLVEERKI--SGDSMIFVEECKHPKAV 343 Query: 384 TIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTL 443 T+ IRG + +IEE R++ DA+ V+ I D R+V GGG+ E+ ++ + + A+ Sbjct: 344 TMLIRGTTEHVIEEVARAVDDAVGVVGCTIEDGRIVSGGGSTEVELSMKLREYAEGISGR 403 Query: 444 EQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQ 503 EQ A+RAFADALEVIP L+EN+G++ I+ + +VRA N G++ DM + Sbjct: 404 EQLAVRAFADALEVIPRTLAENAGLDAIEILVKVRAAHASNGNKCAGLNVFTGAVEDMCE 463 Query: 504 QHVIETLIGKKQQISLATQMVRMILKIDDIRKPGE 538 V+E L K Q I A + M+L+IDD+ + Sbjct: 464 NGVVEPLRVKTQAIQSAAESTEMLLRIDDVIAAEK 498 >5GW5-g nrPDB Length = 534 Score = 554 bits (1429), Expect = e-158, Method: Composition-based stats. Identities = 175/538 (32%), Positives = 305/538 (56%), Gaps = 18/538 (3%) Query: 15 PFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDG 74 P + + + R G +A S+I AAKAVA+ +RT LGP + KM++D G + +TNDG Sbjct: 4 PVVFM--NASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDG 61 Query: 75 ATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEE-AEQLLDRGIHPIRI 133 IL +DV H AK M+ELS++QD+E+GDGTT V++LAG +L + A L+++ IHP+ I Sbjct: 62 HAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVII 121 Query: 134 ADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAV 193 ++A A+E + ++S VD+++ + + + ++G+K V +M E+A++AV Sbjct: 122 IQALKKALTDALEVIKQVSKP--VDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAV 179 Query: 194 LTVADMERRDVDFE---------LIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVE 244 TV + V+ E ++VE GG + D++++KGV+++KD HP+M + +E Sbjct: 180 KTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIE 239 Query: 245 DAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQW 304 + ++ +L CP E K +++ +++ ED+ + + E+E+ + M +QI L I + Sbjct: 240 NPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEK 299 Query: 305 GFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGF-AGLVQEIS 363 G D A H LL+ +R V + IA TG IV R +L +G GL + Sbjct: 300 GVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEM 359 Query: 364 FGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGG 423 G + ++ CK +A TI +RGG+K I+ E R+L DA+ V RN++ + GGG Sbjct: 360 IG--DEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGG 417 Query: 424 AAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVK 483 A E++ ++ ++++A + ++Q+ +A ADA+E IP L +N+G +PI+ ++++RA+ Sbjct: 418 ATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHA- 476 Query: 484 EMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESEE 541 + N GID DM + E + K+Q + A + ++L++DDI +E Sbjct: 477 QGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRKQE 534 >5GW4-h nrPDB Length = 550 Score = 552 bits (1422), Expect = e-157, Method: Composition-based stats. Identities = 162/529 (30%), Positives = 283/529 (53%), Gaps = 12/529 (2%) Query: 16 FLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGA 75 +++K+ S+ G + S+I A AV ++ +LGP G D ++V + T++NDGA Sbjct: 10 IVVLKEGTDASQ--GKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGA 67 Query: 76 TILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIAD 135 TIL ++DV H AK +V++S++QD E+GDGTT V +LAG L++EA+ L+ GI I Sbjct: 68 TILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMK 127 Query: 136 GYEQAARVAIEHLDKISDSVLVDIKD-TEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVL 194 GY +A +A+E +++++ + + E L + A+T + SK++++ ++ V+AVL Sbjct: 128 GYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVL 187 Query: 195 TVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQM---PKKVEDAKIAIL 251 ++ +R D+D +LI ++ GG +E++ I GV K FS+ PKK + KI L Sbjct: 188 SL---DRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSL 244 Query: 252 TCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEAN 311 E K ++ V VEDY+A+ E + E ++Q++ETGAN+ + + D A Sbjct: 245 NVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLAT 304 Query: 312 HLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKM 371 N+ V ++ + A GG I S++ E LG L +E+ G+ + + Sbjct: 305 QFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNL 364 Query: 372 LVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCAL 431 + C ++ T+ +RGG + +I E +RSLHDA+ +++ +++ +V GGGA E+ + Sbjct: 365 --FQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSK 422 Query: 432 AVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGI 491 + + +Q + AFA ALEVIP L EN+G + I+ + ++R K G+ Sbjct: 423 CLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGE-KWYGV 481 Query: 492 DCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESE 540 + D + V E + K ++ AT+ +IL +D+ SE Sbjct: 482 VFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSE 530 >4B2T-D nrPDB Length = 542 Score = 543 bits (1399), Expect = e-155, Method: Composition-based stats. Identities = 200/518 (38%), Positives = 316/518 (61%), Gaps = 12/518 (2%) Query: 25 KSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVD 84 + R + S+I AAKAVA+ +RTSLGP G+DKM+ D GDVT+TNDGATIL M V Sbjct: 28 QDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVL 87 Query: 85 HQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVA 144 H A+++VELSK+QD E GDGTT VV++AG+LL+ +LL +GIHP I++ +++A Sbjct: 88 HPAARMLVELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKG 147 Query: 145 IEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVAD-MERRD 203 IE L +S V++ D E L+ +A T+L SKVV+ ++ ++V+AV+ V D Sbjct: 148 IEILTDMSRP--VELSDRETLLNSAATSLNSKVVSQYSSLLSPMSVDAVMKVIDPATATS 205 Query: 204 VDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTK 263 VD IK+ K+GG ++D +L++G+++ + ++ + +VE AKI ++ PK Sbjct: 206 VDLRDIKIVKKLGGTIDDCELVEGLVLTQKVANSGI-TRVEKAKIGLIQFCLSAPKTDMD 264 Query: 264 HKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGF-----DDEANHLLLQNN 318 +++ V+ + + E+ +++QIK+TG N+ + Q D A H L + Sbjct: 265 NQIVVSDYVQMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMK 324 Query: 319 LPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCK 378 + V+ + +IE I G + V + TA+ LG A L +E+S + K++ I C Sbjct: 325 IMVVKDIEREDIEFICKTIGTKPVAHVDQFTADMLGSAELAEEVSLNGSG-KLIKITGCA 383 Query: 379 NS-RAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEA 437 + + VTI +RG NK++IEEA+RS+HDALCVIR L++ ++ GGGA EI AL +++ + Sbjct: 384 SPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYS 443 Query: 438 DKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKG 497 +E Y +RAFADA+EVIP L+EN+G+NPI T+TE+R R + GI+ G Sbjct: 444 RTLSGMESYCIRAFADAMEVIPSTLAENAGLNPISTVTELRNRHA-QGEKTTGINVRKGG 502 Query: 498 TNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRK 535 +++ ++ V++ L+ ++LAT+ VR ILKIDD+ Sbjct: 503 ISNILEELVVQPLLVSVSALTLATETVRSILKIDDVVN 540 >3AQ1-B nrPDB Length = 500 Score = 541 bits (1393), Expect = e-154, Method: Composition-based stats. Identities = 182/480 (37%), Positives = 291/480 (60%), Gaps = 8/480 (1%) Query: 60 MMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEE 119 M+VD GD+ +TNDGATIL MD+ H AK++VE+SK+QD E+GDGTT VL+G LL + Sbjct: 1 MLVDSMGDIVITNDGATILKEMDIQHPAAKMIVEVSKTQDAEVGDGTTTAAVLSGELLSK 60 Query: 120 AEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVN 179 AE+L+ +G+H I++GY AA E L+ I+ ++ D D LI+ A T + K Sbjct: 61 AEELIMKGVHSTIISEGYRHAAEKCREILETITIAISPD--DEAALIKIAGTAITGKGAE 118 Query: 180 SCHRQMAEIAVNAVLTVADMERRDVD---FELIKVEGKVGGRLEDTKLIKGVIVDKDFSH 236 + +++ + V AV ++ + E + E IK+E + GG ++D++LI G+++DK+ SH Sbjct: 119 AYKEKLSALTVKAVRSIVEEEEDGLKVNVLENIKIEKRAGGSIDDSELIDGLVIDKERSH 178 Query: 237 PQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETG 296 P MP+KVE+AKI +L+CP E K + ++ +TS + E++ EM +++ +G Sbjct: 179 PNMPEKVENAKILLLSCPVEFRKTEVDSEIKITSPGQMQLFLDQEEKMMREMAEKVIASG 238 Query: 297 ANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFA 356 AN+ CQ G DD A + + + + AVR V +++ ++ TG I+ ++T E +G A Sbjct: 239 ANVVFCQKGIDDMAQYYIEKAGIYAVRRVKKSDLKRLSKVTGATIIQDLDQITTEDVGTA 298 Query: 357 GLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDN 416 GLV+E KM + C+NS+AVT+ + GG + +++ +L+DAL V+ +I D Sbjct: 299 GLVEEKEVRG--GKMTYVTGCQNSKAVTVLLHGGTEHVVDSLDHALNDALHVVGVVIEDG 356 Query: 417 RVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTE 476 +VV GGG++E+ +L +S+ A EQ A+ FA+ALEVIP+AL+EN+G++PI M E Sbjct: 357 KVVVGGGSSEVELSLRLSEYASTLKGREQLAVSKFAEALEVIPVALAENAGLDPIDIMVE 416 Query: 477 VRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKP 536 +R++ K N G++ DM + VIE L K Q I+ A + MIL+IDD+ Sbjct: 417 LRSQHEKG-NKNAGLNVYTGEVVDMWENDVIEPLRIKTQAINAAMEATVMILRIDDVVAS 475 >4B2T-A nrPDB Length = 556 Score = 538 bits (1385), Expect = e-153, Method: Composition-based stats. Identities = 168/523 (32%), Positives = 281/523 (53%), Gaps = 15/523 (2%) Query: 27 RLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQ 86 R G ++MAA ++AN +++SLGP GLDKM+VD GDVT+TNDGATIL +++V+H Sbjct: 11 RSTGEAIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLLEVEHP 70 Query: 87 IAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIE 146 AK++ EL+ QD E+GDGTT VV++A LL+ A++L+ + IHP + GY A + A+ Sbjct: 71 AAKVLCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLACKEAVR 130 Query: 147 HLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRD--- 203 ++ + + + D + LI AKT++ SKV+ A + V+AVL + + R Sbjct: 131 YISE-NLIINTDELGRDCLINAAKTSMSSKVIGINGDFFANLVVDAVLAIKYTDIRGQPR 189 Query: 204 VDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTK 263 I V G ++ LI G ++ MPK++ +AKIA L + K K Sbjct: 190 YPVNSINVLKAHGRSQMESMLINGYALNCVVGSQGMPKRIVNAKIACLDFSLQKTKMKLG 249 Query: 264 HKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVR 323 ++ +T E +++ E + +E IQ+I TGAN+ + G DD ++ AVR Sbjct: 250 VQVVITDPEKLDQIRQRESDITKERIQKILATGANVILTTGGIDDMCLKYFVEAGAMAVR 309 Query: 324 WVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLV----QEISFGTTKDKMLVIEQCKN 379 V +++ IA A+G ++ + L E+ A ++ + + D++++I+ K Sbjct: 310 RVLKRDLKRIAKASGATVLSTLANLEGEETFEASMLGQAEEVVQERICDDELILIKNTKA 369 Query: 380 SRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADK 439 + ++ +RG N + +E +RSLHDALCV++ ++ VV GGGA E + ++ + A Sbjct: 370 RTSASVILRGANDFMCDEMERSLHDALCVVKRVLESKSVVPGGGAVEAALSIYLENYATS 429 Query: 440 CPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQ-------VKEMNPALGID 492 + EQ A+ FA +L VIP L+ N+ + + ++RA ++ +G+D Sbjct: 430 MGSREQLAIAEFARSLPVIPNTLAVNAAQDSTDLVAKLRAFHNEAQVNPERKNLKWIGLD 489 Query: 493 CLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRK 535 ++ D KQ V E I K + + AT+ IL+IDD+ K Sbjct: 490 LVNGKPRDNKQAGVFEPTIVKVKSLKFATEAAITILRIDDLIK 532 >4V8R-AG nrPDB Length = 590 Score = 529 bits (1364), Expect = e-150, Method: Composition-based stats. Identities = 174/592 (29%), Positives = 304/592 (51%), Gaps = 70/592 (11%) Query: 15 PFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDG 74 P + + + R G +A S+I AAKAVA+ +RT LGP + KM++D G + +TNDG Sbjct: 4 PVVFM--NASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDG 61 Query: 75 ATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEE-AEQLLDRGIHPIRI 133 IL +DV H AK M+ELS++QD+E+GDGTT V++LAG +L + A L+++ IHP+ I Sbjct: 62 HAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVII 121 Query: 134 ADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAV 193 ++A A+E + ++S VD+++ + + + ++G+K V +M E+A++AV Sbjct: 122 IQALKKALTDALEVIKQVSKP--VDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDAV 179 Query: 194 LTVADMERRDVDFE---------LIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVE 244 TV + V+ E ++VE GG + D++++KGV+++KD HP+M + +E Sbjct: 180 KTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMSRHIE 239 Query: 245 DAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQW 304 + ++ +L CP E K +++ +++ ED+ + + E+E+ + M +QI L I + Sbjct: 240 NPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEK 299 Query: 305 GFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGF-AGLVQEIS 363 G D A H LL+ +R V + IA TG IV R +L +G GL + Sbjct: 300 GVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEM 359 Query: 364 FGTT-------------------------------KDKMLVIEQCK-------------- 378 G K + + Sbjct: 360 IGDEYFSFLDNCKEPGSGSGWSHPQFEKGSGKRRWKKNFIAVSAANRFKKISSSGALGSG 419 Query: 379 ---------NSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISC 429 + +A TI +RGG+K I+ E R+L DA+ V RN++ + GGGA E++ Sbjct: 420 HHHHHHHHGSGKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGATEMAV 479 Query: 430 ALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPAL 489 ++ ++++A + ++Q+ +A ADA+E IP L +N+G +PI+ ++++RA+ + N Sbjct: 480 SVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHA-QGNFTT 538 Query: 490 GIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESEE 541 GID DM + E + K+Q + A + ++L++DDI +E Sbjct: 539 GIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRKQE 590 >4V94-A nrPDB Length = 559 Score = 514 bits (1323), Expect = e-146, Method: Composition-based stats. Identities = 156/531 (29%), Positives = 265/531 (49%), Gaps = 25/531 (4%) Query: 26 SRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDH 85 ++ G + +++A AVAN +++SLGP GLDKM+VD GD TVTNDGATILS++DV H Sbjct: 18 EKISGDDIRNQNVLATMAVANVVKSSLGPVGLDKMLVDDIGDFTVTNDGATILSLLDVQH 77 Query: 86 QIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAI 145 K++VEL++ QD EIGDGTT VV++A LL+ A +L+ IHP I G+ A R AI Sbjct: 78 PAGKILVELAQQQDREIGDGTTSVVIIASELLKRANELVKNKIHPTTIITGFRVALREAI 137 Query: 146 EHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRD-- 203 ++++ S VD E LI AKT++ SK++ + + + V+A+L V + Sbjct: 138 RFINEVL-STSVDTLGKETLINIAKTSMSSKIIGADSDFFSNMVVDALLAVKTQNSKGEI 196 Query: 204 -VDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVE--DAKIAILTCPFEPPKP 260 + + V G ++ L+ G ++ + MPK++ + KIA L + + Sbjct: 197 KYPVKAVNVLKAHGKSATESLLVPGYALNCTVASQAMPKRIAGGNVKIACLDLNLQKARM 256 Query: 261 KTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLP 320 ++++ E + ++K E E +++I + GA + + G DD ++ + Sbjct: 257 AMGVQINIDDPEQLEQIRKREAGIVLERVKKIIDAGAQVVLTTKGIDDLCLKEFVEAKIM 316 Query: 321 AVRWVGGPEIELIAIATGGRIVPRFSELTAEK------LGFAGLVQEISFGTTKDKMLVI 374 VR ++ IA ATG +V S L E+ LG + + + D+ ++I Sbjct: 317 GVRRCKKEDLRRIARATGATLVSSMSNLEGEETFESSYLGLCD--EVVQAKFSDDECILI 374 Query: 375 EQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVS 434 + + +I +RG N ++E +RSLHD+L V++ + VV GGG E + + + Sbjct: 375 KGTSKHSSSSIILRGANDYSLDEMERSLHDSLSVVKRTLESGNVVPGGGCVEAALNIYLD 434 Query: 435 QEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQV-----------K 483 A + EQ A+ FA AL +IP L+ N+ + + + ++R+ + Sbjct: 435 NFATTVGSREQLAIAEFAAALLIIPKTLAVNAAKDSSELVAKLRSYHAASQMAKPEDVKR 494 Query: 484 EMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIR 534 G+D + D V+E I K + + A + IL+ID + Sbjct: 495 RSYRNYGLDLIRGKIVDEIHAGVLEPTISKVKSLKSALEACVAILRIDTMI 545 >5GW4-d nrPDB Length = 528 Score = 506 bits (1303), Expect = e-144, Method: Composition-based stats. Identities = 187/523 (35%), Positives = 314/523 (60%), Gaps = 14/523 (2%) Query: 20 KDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILS 79 + K++ E K++I+AA++VA+ +RTSLGP G+DKM+ G++ ++NDG TIL Sbjct: 7 SNATFKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILK 66 Query: 80 MMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQ 139 M + H +A+++VE+S +QD E GDGTT VV+L GALL AE+LL++GIHP IAD ++ Sbjct: 67 QMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQS 126 Query: 140 AARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADM 199 AA+ +++ L ++ V + D E L++ A T+L SK+V+ +A +AV++VL ++D Sbjct: 127 AAKRSVDILLEMCH--KVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDE 184 Query: 200 ERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKD-FSHPQMPKKVEDAKIAILTCPFEPP 258 ++VD I++ KVGG ++DT++I GV++ + P + E AKI ++ PP Sbjct: 185 NSKNVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPP 244 Query: 259 KPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGF-----DDEANHL 313 KP T++ + V + K E+ + ++IK+ N+ + Q +D A H Sbjct: 245 KPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHF 304 Query: 314 LLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLV 373 L + N+ V+ + EIE ++ G + + T ++LG A LV+E + K++ Sbjct: 305 LSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEE--IDSDGSKIVR 362 Query: 374 IEQCKNSRA---VTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCA 430 + +N+ A V++ IRG N MII+E +RSLHDALCVIR L+++ ++ GGGA EI + Sbjct: 363 VTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEIS 422 Query: 431 LAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALG 490 +S+EA ++ + + FA ALEVIP L+EN+G+N I+ +TE+R++ G Sbjct: 423 RRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGE-LNDG 481 Query: 491 IDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDI 533 I GT + ++H+++ ++ I+LA++ V+ IL+IDDI Sbjct: 482 ISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDI 524 >4B2T-Z nrPDB Length = 531 Score = 504 bits (1299), Expect = e-143, Method: Composition-based stats. Identities = 160/516 (31%), Positives = 267/516 (51%), Gaps = 16/516 (3%) Query: 33 ALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMV 92 AL +I AA+ + + +RT+LGP G KM+V GD+ +T DG +L M + H A L+ Sbjct: 19 ALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQIQHPTASLIA 78 Query: 93 ELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKIS 152 +++ +QDD GDGTT V++ G LL++A+ + G+HP I +G+E A A++ L+++ Sbjct: 79 KVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQFLEQVK 138 Query: 153 DSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVE 212 S + D E LI A+T+L +KV + E V+++L + + +D ++++ Sbjct: 139 VSKEM---DRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIKKQDEP-IDLFMVEIM 194 Query: 213 GKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVE 272 DT LI+G+++D HP M K+VEDA I E K + S E Sbjct: 195 EMKHKSETDTSLIRGLVLDHGARHPDMKKRVEDAYILTCNVSLEYEKTEVNSGFFYKSAE 254 Query: 273 DYKALQKYEKEKFEEMIQQIKETGAN---------LAICQWGFDDEANHLLLQNNLPAVR 323 + + L K E++ E+ +++I E + I Q G D + L + + A+R Sbjct: 255 EREKLVKAERKFIEDRVKKIIELKKKVCGDSDKGFVVINQKGIDPFSLDALAKEGIIALR 314 Query: 324 WVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAV 383 +E + +A GG + +L + LG AGLV E + G ++K IE+C N R+V Sbjct: 315 RAKRRNMERLTLACGGIALNSLDDLNPDCLGHAGLVYEYTLG--EEKFTFIEKCNNPRSV 372 Query: 384 TIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTL 443 T+ I+G NK + + K ++ D L ++N I D VV G GA E++ A A+ + Sbjct: 373 TLLIKGPNKHTLTQIKDAIRDGLRAVKNAIDDGCVVPGAGAVEVAMAEALVKYKPSVKGR 432 Query: 444 EQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQ 503 Q ++AFADAL +IP L++NSG + +T+ +V+A E +G+D + Sbjct: 433 AQLGVQAFADALLIIPKVLAQNSGFDLQETLVKVQAEH-SESGQLVGVDLNTGEPMVAAE 491 Query: 504 QHVIETLIGKKQQISLATQMVRMILKIDDIRKPGES 539 + + KKQ + T + IL +D+I + G S Sbjct: 492 AGIWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMS 527 >4B2T-Q nrPDB Length = 548 Score = 496 bits (1277), Expect = e-140, Method: Composition-based stats. Identities = 165/523 (31%), Positives = 273/523 (52%), Gaps = 13/523 (2%) Query: 18 IIKDQDRKSRLMGLE-ALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGAT 76 ++K+ + GLE A+ +I A K +A T RT+ GPNG++KM+++ + VTND AT Sbjct: 14 MLKEGAKH--FSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAAT 71 Query: 77 ILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADG 136 IL ++V H AK++V S Q+ E+GDGT V+V AGALLE AE+LL G+ + +G Sbjct: 72 ILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRLGLSVSEVIEG 131 Query: 137 YEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTV 196 YE A + A E L + +++D + + T++ SK + IA V Sbjct: 132 YEIACKKAHEILPDLVCCSAKNLRDVDEVSSLLHTSVMSKQYGNEVFLAKLIAQACVSIF 191 Query: 197 ADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFE 256 D +VD I+V +G + + ++ G++ K+ V+DAKIA+ +CPF+ Sbjct: 192 PDSGHFNVD--NIRVCKILGSGVHSSSVLHGMVFKKETEGDV--TSVKDAKIAVYSCPFD 247 Query: 257 PPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQ 316 +TK + + S E+ K E+ + ++ I +TGAN+ + D A H + Sbjct: 248 GMITETKGTVLIKSAEELMNFSKGEENLMDAQVKAIADTGANVVVTGGRVADMALHYANK 307 Query: 317 NNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQ 376 N+ VR ++ + G +PR + E++G V G T +++V + Sbjct: 308 YNIMLVRLNSKWDLRRLCKTVGATALPRLNPPVLEEMGHCDSVYLSEVGDT--QVVVFKH 365 Query: 377 CKNSRAV-TIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQ 435 K A+ TI +RG ++++ +R++ D + + L RD R+V GGGA EI A ++ Sbjct: 366 EKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITS 425 Query: 436 EADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDC-- 493 + CP LEQYA++ FA+A E IP AL+ENSG+ + ++++ A +E N +G+D Sbjct: 426 YGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVH-QEGNKNVGLDIEA 484 Query: 494 LHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKP 536 DM + V++T +GK I LAT +L++D I Sbjct: 485 EVPAVKDMLEAGVLDTYLGKYWAIKLATNAAVTVLRVDQIIMA 527 >5GW5-z nrPDB Length = 546 Score = 496 bits (1277), Expect = e-140, Method: Composition-based stats. Identities = 139/524 (26%), Positives = 261/524 (49%), Gaps = 19/524 (3%) Query: 33 ALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMV 92 ALK ++ +A+ + + + T+LGP G KM+VD G++ +T DG +L+ M + A L+ Sbjct: 18 ALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIA 77 Query: 93 ELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKIS 152 + +QD+ GDGTT VV L G LL +A + + G+HP I DG+E A + +++ LD+ Sbjct: 78 RAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFK 137 Query: 153 DSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVE 212 S D E L+Q A+++L +KV + I +AVL+V D + ++D ++++ Sbjct: 138 ISKTNLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADNLDLHMVEIM 197 Query: 213 GKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVE 272 +DT IKG+++D HP MP +V++A + IL E K + +S + Sbjct: 198 QMQHLSPKDTTFIKGLVLDHGGRHPDMPTRVKNAYVLILNVSLEYEKTEVNSGFFYSSAD 257 Query: 273 DYKALQKYEKEKFEEMIQQIKETGAN----------LAICQWGFDDEANHLLLQNNLPAV 322 L E++ + +++I + + I Q G D + + ++N+ A+ Sbjct: 258 QRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILAL 317 Query: 323 RWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRA 382 R +E + + TGG +L+ + LGF+GLV + + G ++K + + + ++ Sbjct: 318 RRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIG--EEKFTYVTENTDPKS 375 Query: 383 VTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQ---EADK 439 TI I+G + + K ++ D L + N+++D ++ G GA I+ + + Sbjct: 376 CTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKLG 435 Query: 440 CPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMT----EVRARQVKEMNPALGIDCLH 495 + + AFA+AL VIP L +NSG +P+ + E+ Q + +G+D Sbjct: 436 AKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDLNI 495 Query: 496 KGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGES 539 + D + + ++ + I+ AT + +L D++ + G S Sbjct: 496 GDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRS 539 >4B2T-B nrPDB Length = 535 Score = 494 bits (1271), Expect = e-140, Method: Composition-based stats. Identities = 177/526 (33%), Positives = 282/526 (53%), Gaps = 14/526 (2%) Query: 15 PFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDK--DGDVTVTN 72 P I K + R A S + A A+ + ++++LGP G+DK+++ D + VTN Sbjct: 8 PVNIFKAGADEER--AETARLSSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTN 65 Query: 73 DGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIR 132 DGATIL + VD+ AK++V++S+ QDDE+GDGTT V VLA LL EAE L+ + IHP Sbjct: 66 DGATILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQT 125 Query: 133 IADGYEQAARVAIE-HLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVN 191 I G+ +A + A + L+ D ++K + L+ A TTL SK++ ++AV Sbjct: 126 IIAGWREATKAARQALLNSAVDHGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHFTKLAVE 185 Query: 192 AVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAIL 251 AVL + + + E I V K+GG L D+ L +G ++DK Q PK++E+AKI I Sbjct: 186 AVLRL----KGSGNLEAIHVIKKLGGSLADSYLDEGFLLDKKIGVNQ-PKRIENAKILIA 240 Query: 252 TCPFEPPKPKT-KHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEA 310 + K K ++ V S ++ EKEK +E +++I + G N I + + Sbjct: 241 NTGMDTDKIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYP 300 Query: 311 NHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDK 370 L + A+ +E +A+ TGG I F KLG L++E+ G +DK Sbjct: 301 EQLFGAAGVMAIEHADFVGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVMIG--EDK 358 Query: 371 MLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCA 430 ++ A TI +RG + I++EA+RSLHDALCV+ ++D+R VYGGG +E+ A Sbjct: 359 LIHFSGVALGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDSRTVYGGGCSEMLMA 418 Query: 431 LAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALG 490 AV+Q A + P E AM ++A AL ++P +++N+G + + ++RA E G Sbjct: 419 HAVTQLASRTPGKEAVAMESYAKALRMLPTIIADNAGYDSADLVAQLRAAH-SEGKTTAG 477 Query: 491 IDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKP 536 +D DM + E+ K+Q + A + +IL++D+I K Sbjct: 478 LDMKEGTIGDMSVLGITESFQVKRQVLLSAAEAAEVILRVDNIIKA 523 >4V8R-AB nrPDB Length = 527 Score = 490 bits (1262), Expect = e-139, Method: Composition-based stats. Identities = 175/519 (33%), Positives = 283/519 (54%), Gaps = 12/519 (2%) Query: 22 QDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVT-VTNDGATILSM 80 D+ + A S + A AV + ++++LGP G+DK++ + VTNDGATIL Sbjct: 7 GDQVTEERAENARLSAFVGAIAVGDLVKSTLGPKGMDKLLQSASSNTCMVTNDGATILKS 66 Query: 81 MDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDR-GIHPIRIADGYEQ 139 + +D+ AK++V +SK QDDE+GDGTT V VL+ LL EAE+L+D+ IHP I +GY Sbjct: 67 IPLDNPAAKVLVNISKVQDDEVGDGTTSVTVLSAELLREAEKLIDQSKIHPQTIIEGYRL 126 Query: 140 AARVAIEHLDKIS-DSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVAD 198 A+ A++ L K + D+ E LI AKTTL SK+++ AE+A NA+L + Sbjct: 127 ASAAALDALTKAAVDNSHDKTMFREDLIHIAKTTLSSKILSQDKDHFAELATNAILRL-- 184 Query: 199 MERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPP 258 + + E I++ +GG+L D+ L +G I+ K F + Q PK++E+AKI I + Sbjct: 185 --KGSTNLEHIQIIKILGGKLSDSFLDEGFILAKKFGNNQ-PKRIENAKILIANTTLDTD 241 Query: 259 KPKT-KHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQN 317 K K K V S L+K E+EK + I +I + G N I + D L Sbjct: 242 KVKIFGTKFKVDSTAKLAQLEKAEREKMKNKIAKISKFGINTFINRQLIYDYPEQLFTDL 301 Query: 318 NLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQC 377 + ++ +E +A+ TGG +V F E + KLG +++EI G + L C Sbjct: 302 GINSIEHADFEGVERLALVTGGEVVSTFDEPSKCKLGECDVIEEIMLG--EQPFLKFSGC 359 Query: 378 KNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEA 437 K A TI +RG ++EA+RSLHDAL V+ ++ R V GGG AE+ + AV EA Sbjct: 360 KAGEACTIVLRGATDQTLDEAERSLHDALSVLSQTTKETRTVLGGGCAEMVMSKAVDTEA 419 Query: 438 DKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKG 497 + A+ AFA AL +P L++N+G + + ++++R+ ++ + G+D + Sbjct: 420 QNIDGKKSLAVEAFARALRQLPTILADNAGFDSSELVSKLRSSIYNGISTS-GLDLNNGT 478 Query: 498 TNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKP 536 DM+Q ++E+ K+ +S A++ ++L++D+I + Sbjct: 479 IADMRQLGIVESYKLKRAVVSSASEAAEVLLRVDNIIRA 517 >5GW5-q nrPDB Length = 568 Score = 485 bits (1249), Expect = e-137, Method: Composition-based stats. Identities = 138/539 (25%), Positives = 272/539 (50%), Gaps = 18/539 (3%) Query: 18 IIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATI 77 + K + +KS I A + + TS+GP G +K++V+ G + +TND AT+ Sbjct: 13 LFKQGYNSYSNADGQIIKS-IAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATM 71 Query: 78 LSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGY 137 L +D+ H K++V ++ Q ++GDGT V++LAG LL +E+L+ G+ + I GY Sbjct: 72 LRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGY 131 Query: 138 EQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNS--CHRQMAEIAVNAVLT 195 A + ++ LD++ + D D L++ K + SK S ++ AV+ VL Sbjct: 132 NMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGSEDILSELVSEAVSHVLP 191 Query: 196 VADM--ERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDF-SHPQMPKKVEDAKIAILT 252 VA E + + I+V +GG L ++ +IKG++ +++ H + + + K+A+ T Sbjct: 192 VAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFT 251 Query: 253 CPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANH 312 CP + +TK + + + ++ K E+++ + M+++I + G + G + A H Sbjct: 252 CPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGELALH 311 Query: 313 LLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKML 372 L + + ++ E+ + G +PR T E+LG V+ + G + + Sbjct: 312 YLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGDRVTVF 371 Query: 373 VIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRD--NRVVYGGGAAEISCA 430 EQ + SR TI +RG + +++ +R++ D + ++ L++ +++ G GA EI Sbjct: 372 KQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATEIELI 431 Query: 431 LAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALG 490 +++ ++ P L Q A++ FA A EV+P L+E +G++ + + + A A+ Sbjct: 432 SRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPGAVK 491 Query: 491 IDCLHKGTN----------DMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGES 539 D L+KG + D++++++ + L KK I++AT+ +L ID I ++ Sbjct: 492 TDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQIIMAKKA 550 >5X9V-A nrPDB Length = 521 Score = 421 bits (1083), Expect = e-118, Method: Composition-based stats. Identities = 145/522 (27%), Positives = 253/522 (48%), Gaps = 27/522 (5%) Query: 20 KDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILS 79 K+ + +AL S+ A KA+ + SLGP GLD M+VD+ G+V VTNDG TIL+ Sbjct: 3 KENQTQEIEERYQALFSNAAAVKALTQVVANSLGPKGLDAMLVDRFGEVVVTNDGVTILT 62 Query: 80 MMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQ 139 +MD H A+++V ++++Q+ E+GDGTT VLAGAL+ E + +G+ ++ G + Sbjct: 63 LMDAQHPAARMVVNMARAQEREVGDGTTTAAVLAGALVSEGVNQILKGVPVSKVLAGMNR 122 Query: 140 AARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADM 199 A A+ + K +++ V + L+ A K+ ++A I +A + D Sbjct: 123 ALNHALFLIRK--NAIKVGSITDDRLLAAA------KIAGRGDERVAAILRDAAAMLED- 173 Query: 200 ERRDVDFELIK-VEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPP 258 + +D F+L V KVG DT LI GV+++K + +K+++ ++ +L P Sbjct: 174 KLQDPGFKLADLVLAKVGA---DTTLIPGVVINKSPLWEEGSQKLQEVRLLVLDDGLYPE 230 Query: 259 KPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNN 318 + + + E Y QK F+E ++++KE G L + G D A +N Sbjct: 231 EVEEEALASEAGFEQYLKNQK----IFQENLKKLKELGVKLILLTRGISDIAEEFCYENE 286 Query: 319 LPAVRWVGGPEIELIAIATGGRIVPRFS-----ELTAEKLGFAGLVQEISFGTTKDKMLV 373 + + + E++ + TG R R S E + LG+A F ++ + Sbjct: 287 IMVITRITQKELKRVLEFTGARAAKRTSLNKPVEELQKMLGYA----RTCFYDSRLDFTI 342 Query: 374 IEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAV 433 IE T+ I +++E +R DA R V+ GGGA + + V Sbjct: 343 IEGGAGKATATVLIGAATDEVVDEQERIAKDAAGSFAAAYRSG-VLPGGGAFFLYLSREV 401 Query: 434 SQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDC 493 ++ P +E Y + AF++AL+V ++EN+G N ++ + ++ QV++ N ALG+D Sbjct: 402 ESLKNRLPGMESYGVMAFSEALKVPFRVMAENAGFNGLEKLGDLMTLQVQKNNYALGLDF 461 Query: 494 LHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRK 535 DM V++ Q + A+++ +LKI+ I K Sbjct: 462 ETGEFIDMIAGGVVDPAEVVYQAVKNASEVAISLLKINTIIK 503 >4V4O-A nrPDB Length = 543 Score = 264 bits (676), Expect = 5e-71, Method: Composition-based stats. Identities = 109/554 (19%), Positives = 214/554 (38%), Gaps = 94/554 (16%) Query: 33 ALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQ----IA 88 A ++ AVAN ++ +LGP G + ++ K G T+T DG T+ ++++ A Sbjct: 11 ARRALERGVNAVANAVKVTLGPRGRNVVLEKKFGSPTITKDGVTVAKEVELEDHLENIGA 70 Query: 89 KLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHL 148 +L+ E++ +D GDGTT VLA A++ E + + G +P+ + G E+A A+E + Sbjct: 71 QLLKEVASKTNDVAGDGTTTATVLAQAIVREGLKNVAAGANPLALKRGIEKAVEAAVEKI 130 Query: 149 DKISDSVLVDIKDTEPLIQTAKTTLG-SKVVNSCHRQMAEIAVNAVLTVADMERRDVDFE 207 ++ + ++D + + + A + +V M ++ ++TV + + + + + Sbjct: 131 KALA----IPVEDRKAIEEVATISANDPEVGKLIADAMEKVGKEGIITVEESKSLETELK 186 Query: 208 LIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQ-MPKKVEDAKIAILTCPFEPPKPKTKHKL 266 + E + KG I ++P+ M +EDA I I+ + Sbjct: 187 FV----------EGYQFDKGYISPYFVTNPETMEAVLEDAFILIV-------------EK 223 Query: 267 DVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLP------ 320 V++V + + ++Q+ +TG L I + EA L+ N L Sbjct: 224 KVSNVRELLPI-----------LEQVAQTGKPLLIIAEDVEGEALATLVVNKLRGTLSVA 272 Query: 321 AVRWVGGPE-----IELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIE 375 AV+ G + ++ IA TGG ++ E + L + TKD+ ++ Sbjct: 273 AVKAPGFGDRRKEMLKDIAAVTGGTVISEELGFKLENATLSMLGRAERVRITKDETTIVG 332 Query: 376 QCKNSRAV-----------------------------------TIFIRGGNKMIIEEAKR 400 + I + + ++E K Sbjct: 333 GKGKKEDIEARINGIKKELETTDSEYAREKLQERLAKLAGGVAVIRVGAATETELKEKKH 392 Query: 401 SLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPM 460 DAL R + + +V GGG + AV + K E + ALE Sbjct: 393 RFEDALNATRAAVEEG-IVPGGGVTLLRAISAVEELIKKLEGDEATGAKIVRRALEEPAR 451 Query: 461 ALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLA 520 ++EN+G + ++ A NP G + DM + +++ + + A Sbjct: 452 QIAENAGYEGSVIVQQILAE---TKNPRYGFNAATGEFVDMVEAGIVDPAKVTRSALQNA 508 Query: 521 TQMVRMILKIDDIR 534 + +IL + + Sbjct: 509 ASIGALILTTEAVV 522 >1IOK-A nrPDB Length = 545 Score = 239 bits (609), Expect = 3e-63, Method: Composition-based stats. Identities = 95/553 (17%), Positives = 214/553 (38%), Gaps = 97/553 (17%) Query: 29 MGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDV----D 84 +A + +A+ ++ +LGP G + ++ G +T DG ++ +++ + Sbjct: 8 FNSDARDRMLKGVNILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEIELSDKFE 67 Query: 85 HQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVA 144 + A+++ E++ +DE GDGTT VLA A++ E + + G++P+ + G + A Sbjct: 68 NMGAQMVREVASRTNDEAGDGTTTATVLAQAIVREGLKAVAAGMNPMDLKRGIDVATAKV 127 Query: 145 IEHLDKISDSVLVDIKDTEPLIQTAKTTLGSK--VVNSCHRQMAEIAVNAVLTVADMERR 202 +E + + V D+ + Q + + + M + V+TV + + Sbjct: 128 VEAIKSAARPV----NDSSEVAQVGTISANGESFIGQQIAEAMQRVGNEGVITVEENKGM 183 Query: 203 DVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHP-QMPKKVEDAKIAILTCPFEPPKPK 261 + + E++ E + +G + ++ +M ++EDA I + Sbjct: 184 ETEVEVV----------EGMQFDRGYLSPYFVTNADKMIAELEDAYILL----------- 222 Query: 262 TKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNN--- 318 H+ ++S++ L ++ + ++ L I + EA L+ N Sbjct: 223 --HEKKLSSLQPMVPL-----------LESVIQSQKPLLIVAEDVEGEALATLVVNKLRG 269 Query: 319 ---LPAVRWVGGPE-----IELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDK 370 + AV+ G + ++ IAI TGG+++ + E + L + KD Sbjct: 270 GLKIAAVKAPGFGDRRKAMLQDIAILTGGQVISEDLGMKLENVTIDMLGRAKKVSINKDN 329 Query: 371 MLVIEQCKNSRAV-----------------------------------TIFIRGGNKMII 395 +++ + I + G ++ + Sbjct: 330 TTIVDGAGEKAEIEARVSQIRQQIEETTSDYDREKLQERVAKLAGGVAVIRVGGMTEIEV 389 Query: 396 EEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADAL 455 +E K + DAL R +++ +V GGG A + A + + + + + AL Sbjct: 390 KERKDRVDDALNATRAAVQEG-IVVGGGVALVQGAKVLEGLS-GANSDQDAGIAIIRRAL 447 Query: 456 EVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQ 515 E ++EN+G++ +VR + + A G + + DM + VI+ + Sbjct: 448 EAPMRQIAENAGVDGAVVAGKVR----ESSDKAFGFNAQTEEYGDMFKFGVIDPAKVVRT 503 Query: 516 QISLATQMVRMIL 528 + A + +++ Sbjct: 504 ALEDAASVAGLLI 516 >4AAR-A nrPDB Length = 548 Score = 238 bits (607), Expect = 5e-63, Method: Composition-based stats. Identities = 100/552 (18%), Positives = 203/552 (36%), Gaps = 96/552 (17%) Query: 29 MGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQI- 87 G +A + +A+ ++ +LGP G + ++ G T+T DG ++ ++++ + Sbjct: 8 FGNDARVKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFE 67 Query: 88 ---AKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVA 144 A+++ E++ +D GDGTT VLA A++ E + + G++P+ + G ++A A Sbjct: 68 NMGAQMVKEVASKANDAAGDGTTTATVLAQAIITEGLKAVAAGMNPMDLKRGIDKAVTAA 127 Query: 145 IEHLDKISDSVLVDIKDTEPLIQTAKTTLGS--KVVNSCHRQMAEIAVNAVLTVADMERR 202 +E L +S V D++ + Q + S V M ++ V+TV D Sbjct: 128 VEELKALS----VPCSDSKAIAQVGTISANSDETVGKLIAEAMDKVGKEGVITVEDGTGL 183 Query: 203 DVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKT 262 + + +++G+ D+ + P K E + L PF Sbjct: 184 QDELD----------------VVEGMQFDRGYLSPYFINKPETGAVE-LESPFILL---- 222 Query: 263 KHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQN----- 317 ++++ + + ++ + + G L I + EA L+ N Sbjct: 223 -ADKKISNIREMLPV-----------LEAVAKAGKPLLIIAEDVEGEALATLVVNTMRGI 270 Query: 318 -NLPAVRWVGGPE-----IELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKM 371 + AV+ G + ++ IA TGG ++ + EK L Q KD Sbjct: 271 VKVAAVKAPGFGDRRKAMLQDIATLTGGTVISEEIGMELEKATLEDLGQAKRVVINKDTT 330 Query: 372 LVIEQCKNSRAV-----------------------------------TIFIRGGNKMIIE 396 +I+ A+ I + ++ ++ Sbjct: 331 TIIDGVGEEAAIQGRVAQIRQQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMK 390 Query: 397 EAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALE 456 E K + AL R + + VV GGG A I A ++ + ++ A+E Sbjct: 391 EKKARVEAALHATRAAVEEG-VVAGGGVALIRVASKLADL-RGQNEDQNVGIKVALRAME 448 Query: 457 VIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQ 516 + N G P V A VK + G + + +M +++ + Sbjct: 449 APLRQIVLNCGEEPS-----VVANTVKGGDGNYGYNAATEEYGNMIDMGILDPTKVTRSA 503 Query: 517 ISLATQMVRMIL 528 + A + +++ Sbjct: 504 LQYAASVAGLMI 515 >5DA8-A nrPDB Length = 545 Score = 236 bits (601), Expect = 3e-62, Method: Composition-based stats. Identities = 104/562 (18%), Positives = 208/562 (37%), Gaps = 103/562 (18%) Query: 23 DRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMD 82 K L EA + +AN ++ +LGP G + ++ K G T T DG T+ ++ Sbjct: 2 TAKDILFDAEARTKLKVGVDKLANAVKVTLGPAGRNVLIDKKFGAPTSTKDGVTVAKEIE 61 Query: 83 VDHQI----AKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYE 138 + + A+++ E++ D GDGTT VLA A+ E + + G PI + G + Sbjct: 62 LVDPVENMGAQMVREVASKTSDVAGDGTTTATVLAQAIYREGLKNVTAGARPIDLKRGID 121 Query: 139 QAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLG--SKVVNSCHRQMAEIAVNAVLTV 196 +A + + L IS S+ + + Q + ++ M ++ + V+TV Sbjct: 122 RAVKEVVAELRNISRSI----SGKKEIAQVGTISANNDPEIGELIAEAMDKVGKDGVITV 177 Query: 197 ADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQ-MPKKVEDAKIAILTCPF 255 + + + + +++ E + +G + ++ + M ++++A I I Sbjct: 178 EEAKGMETELKVV----------EGMQFDRGYLSPYFVTNSETMEAELDEALILI----- 222 Query: 256 EPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLL 315 H ++++++ + +++ ++G L I + EA L+ Sbjct: 223 --------HDKKISNMKELLPI-----------LEKAAQSGRPLLIIAEDIEGEALATLV 263 Query: 316 QNNLP------AVRWVGGPE-----IELIAIATGGRIVPRFSELTAEKLGFAGLVQEISF 364 N L AV+ G + +E IAI TGG ++ E A L Q Sbjct: 264 VNKLRGTLKVAAVKAPGFGDRRKAMLEDIAILTGGTVISEEKGYKLENATMAYLGQAARI 323 Query: 365 GTTKDKMLVIEQ----------------------------------CKNSRAVTIF-IRG 389 KD ++E K S V + I Sbjct: 324 TIDKDNTTIVEGKGKQEEIKARINEIKGQIEKSTSDYDTEKLQERLAKLSGGVAVLKIGA 383 Query: 390 GNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLE--QYA 447 ++ ++E K + DAL R +++ VV GG ++ A A E + Sbjct: 384 STEVEMKEKKARVEDALHATRAAVQEGIVVGGG----VALIRAAKGLAKAVADNEDQKTG 439 Query: 448 MRAFADALEVIPMALSENSG-MNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHV 506 + ALE + N+G + + +V K G + + ++ + V Sbjct: 440 IEIIRRALEEPLRQIVANTGTTDGAVVLEKV-----KNAEGDYGFNARTEQYENLIEAGV 494 Query: 507 IETLIGKKQQISLATQMVRMIL 528 ++ + + A + ++L Sbjct: 495 VDPTKVTRSALENAASVASILL 516 >4PJ1-A nrPDB Length = 558 Score = 225 bits (574), Expect = 3e-59, Method: Composition-based stats. Identities = 104/561 (18%), Positives = 209/561 (37%), Gaps = 99/561 (17%) Query: 21 DQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSM 80 K G +A + +A+ + ++GP G ++ G VT DG T+ Sbjct: 26 QGSAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKS 85 Query: 81 MDVDHQI----AKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADG 136 +D+ + AKL+ +++ + ++E GDGTT VLA ++ +E + + +G +P+ I G Sbjct: 86 IDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRG 145 Query: 137 YEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGS--KVVNSCHRQMAEIAVNAVL 194 A I L K S V E + Q A + ++ N M ++ V+ Sbjct: 146 VMLAVDAVIAELKKQSKPVTTP----EEIAQVATISANGDKEIGNIISDAMKKVGRKGVI 201 Query: 195 TVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPK-KVEDAKIAILTC 253 TV D + + + E+I E K +G I + + K + +DA + + Sbjct: 202 TVKDGKTLNDELEII----------EGMKFDRGYISPYFINTSKGQKCEFQDAYVLL--- 248 Query: 254 PFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHL 313 + ++S++ ++ L I D EA Sbjct: 249 ----------SEKKISSIQSIVP-----------ALEIANAHRKPLVIIAEDVDGEALST 287 Query: 314 LLQN------NLPAVRWVGGPE-----IELIAIATGGRIVPRFS-ELTAEKLGFAGLVQE 361 L+ N + AV+ G + ++ +AIATGG + L E + L + Sbjct: 288 LVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKV 347 Query: 362 ISFGTTKDKMLVIEQ----------------------------------CKNSRAVTIF- 386 TKD ++++ K S V + Sbjct: 348 GKVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLK 407 Query: 387 IRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQY 446 + G + + + E K + DAL R + + +V GGG A + C A+ ++ Sbjct: 408 VGGTSDVEVNEKKDRVTDALNATRAAVEEG-IVLGGGCALLRCIPALDSLTPANED-QKI 465 Query: 447 AMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHV 506 + L++ M +++N+G+ + ++ + + +G D + +M ++ + Sbjct: 466 GIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIM-----QSSSEVGYDAMAGDFVNMVEKGI 520 Query: 507 IETLIGKKQQISLATQMVRMI 527 I+ + + A + ++ Sbjct: 521 IDPTKVVRTALLDAAGVASLL 541 >1SJP-A nrPDB Length = 504 Score = 224 bits (571), Expect = 8e-59, Method: Composition-based stats. Identities = 106/529 (20%), Positives = 199/529 (37%), Gaps = 98/529 (18%) Query: 65 DGDVTVTNDGATILSMMDVDHQI----AKLMVELSKSQDDEIGDGTTGVVVLAGALLEEA 120 G T+TNDG +I ++++ A+L+ E++K DD GDGTT VLA AL+ E Sbjct: 1 WGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREG 60 Query: 121 EQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSK-VVN 179 + + G +P+ + G E+A E L K +++ E + TA + G + + + Sbjct: 61 LRNVAAGANPLGLKRGIEKAVEKVTETLLK----GAKEVETKEQIAATAAISAGDQSIGD 116 Query: 180 SCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQM 239 M ++ V+TV + + EL E + KG I + P+ Sbjct: 117 LIAEAMDKVGNEGVITVEESNTFGLQLELT----------EGMRFDKGYISGYFVTDPER 166 Query: 240 PKKV-EDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGAN 298 + V ED I +++ V++V+D L ++++ G Sbjct: 167 QEAVLEDPYILLVSS-------------KVSTVKDLLPL-----------LEKVIGAGKP 202 Query: 299 LAICQWGFDDEANHLLLQNNL------PAVRWVGGPE-----IELIAIATGGRIVPRFSE 347 L I + EA L+ N + AV+ G + ++ +AI TGG+++ Sbjct: 203 LLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISEEVG 262 Query: 348 LTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVT----------------------- 384 LT E + L + TKD+ ++E ++ A+ Sbjct: 263 LTLENADLSLLGKARKVVVTKDETTIVEGAGDTDAIAGRVAQIRQEIENSDSDYDREKLQ 322 Query: 385 ------------IFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALA 432 I ++ ++E K + DA+ + + + +V GGG + A Sbjct: 323 ERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEG-IVAGGGVTLLQAAPT 381 Query: 433 VSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGID 492 + + K E ALE ++ NSG+ P +VR + G++ Sbjct: 382 LDEL--KLEGDEATGANIVKVALEAPLKQIAFNSGLEPGVVAEKVR-----NLPAGHGLN 434 Query: 493 CLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESEE 541 D+ V + + + + A + + L + + +E Sbjct: 435 AQTGVYEDLLAAGVADPVKVTRSALQNAASIAGLFLTTEAVVADKPEKE 483 >5CDI-A nrPDB Length = 552 Score = 207 bits (526), Expect = 1e-53, Method: Composition-based stats. Identities = 104/550 (18%), Positives = 205/550 (37%), Gaps = 80/550 (14%) Query: 31 LEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQI--- 87 ++ALK +A + ++GP G + ++ K G + NDG TI +++ + Sbjct: 11 MQALKRMQAGVDKLATVVGVTIGPKGRNVVLESKFGAPKIVNDGVTIAREVELSDPVENI 70 Query: 88 -AKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIE 146 A L+ + + +D GDGTT VL+ A + E +++ G +P+++ G E+ + ++ Sbjct: 71 GATLVRQAAARTNDTAGDGTTTATVLSAAFIAEGMKIVSAGTNPVQLVRGMEKTVQELVK 130 Query: 147 HLDKISDSVLVD--IKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDV 204 L K+S V D + + + T +GS + MA++ V+T+ E + Sbjct: 131 ELRKMSSVVQTDKDLANVACVSAGGNTDIGSLI----SDAMAKVGRTGVVTME--EGKTA 184 Query: 205 DFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQ-MPKKVEDAKIAILTCPFEPPK---P 260 + +L+ VEG + +G + P+ M + E+ KI ++ + Sbjct: 185 EDQLVFVEG--------MQFERGYTSPYFVTDPERMICEYENCKILLVDKKISTARDIIT 236 Query: 261 KTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLP 320 + + A + ++ ++ +++ T +AI GF + + L Sbjct: 237 ILESAIRGNYPLLIMAEEVEQEALATLVVNKLRGTLKVVAIKAPGFGERRSSYL------ 290 Query: 321 AVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNS 380 E IAI TGG +V ++ E+ A L TK++ V+ + Sbjct: 291 ----------EDIAILTGGTVVRDEMGVSLEQATDAVLGTAAKITITKERTTVVGDGSTA 340 Query: 381 RAVT-----------------------------------IFIRGGNKMIIEEAKRSLHDA 405 V I + + ++E K + DA Sbjct: 341 ADVAARVKQIRNLQMQTDQDYEREKLQERIARLSGGVAIIQVGAQTETELKEKKLRVEDA 400 Query: 406 LCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLE-QYAMRAFADALEVIPMALSE 464 L R + + VV GGG + + V + E Q AL +++ Sbjct: 401 LNATRAAVEEG-VVPGGGCTLLRLSEKVDVIKRRMTDPEQQMGADIIKRALCYPIKLIAQ 459 Query: 465 NSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMV 524 N+G+N M EV P G + ++ + +I+ + + A + Sbjct: 460 NAGVNGSVVMNEVM---KNLDRPHYGYNAATDSFENLMETGIIDPSKVVRCSMENAVSVA 516 Query: 525 RMILKIDDIR 534 + L D + Sbjct: 517 KTFLLADVVV 526 >1GN1-A nrPDB Length = 178 Score = 190 bits (482), Expect = 2e-48, Method: Composition-based stats. Identities = 52/174 (29%), Positives = 99/174 (56%), Gaps = 3/174 (1%) Query: 219 LEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQ 278 +ED+ +++GV+++KD +HP+M + +++ +I +L E K +++ +++T ED+ + Sbjct: 1 MEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRIL 60 Query: 279 KYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATG 338 + E+E ++ + I + ++ I + G D A H L++ N+ A+R V + IA A G Sbjct: 61 QMEEEYIHQLCEDIIQLKPDVVITEKGISDLAQHYLMRANVTAIRRVRKTDNNRIARACG 120 Query: 339 GRIVPRFSELTAEKLGF-AGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGN 391 RIV R EL + +G AGL++ G + I CK+ +A TI +RG + Sbjct: 121 ARIVSRPEELREDDVGTGAGLLEIKKIG--DEYFTFITDCKDPKACTILLRGAS 172 >1E0R-B nrPDB Length = 159 Score = 170 bits (431), Expect = 1e-42, Method: Composition-based stats. Identities = 57/155 (36%), Positives = 83/155 (53%), Gaps = 2/155 (1%) Query: 225 IKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEK 284 + G+IVDK+ HP MP V+DAKIA+L P E KP+ L + + E+ Sbjct: 1 MNGIIVDKEKVHPGMPDVVKDAKIALLDAPLEIKKPEFDTNLRIEDPSMIQKFLAQEENM 60 Query: 285 FEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPR 344 EM+ +IK GAN+ I Q G DD A H L + + AVR V +++ +A ATG IV Sbjct: 61 LREMVDKIKSVGANVVITQKGIDDMAQHYLSRAGIYAVRRVKKSDMDKLAKATGASIVST 120 Query: 345 FSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKN 379 E+++ LG A V+++ G +D M + KN Sbjct: 121 IDEISSSDLGTAERVEQVKVG--EDYMTFVTGSKN 153 >1ASS-A nrPDB Length = 159 Score = 170 bits (431), Expect = 2e-42, Method: Composition-based stats. Identities = 54/155 (34%), Positives = 89/155 (57%), Gaps = 2/155 (1%) Query: 225 IKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEK 284 + G+++DK+ H +MP V++AKIA++ E K + + K+ ++ + E Sbjct: 1 MSGIVIDKEKVHSKMPDVVKNAKIALIDSALEIKKTEIEAKVQISDPSKIQDFLNQETNT 60 Query: 285 FEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPR 344 F++M+++IK++GAN+ +CQ G DD A H L + + AVR V ++E +A ATG +IV Sbjct: 61 FKQMVEKIKKSGANVVLCQKGIDDVAQHYLAKEGIYAVRRVKKSDMEKLAKATGAKIVTD 120 Query: 345 FSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKN 379 +LT LG A V+E G D+M + CKN Sbjct: 121 LDDLTPSVLGEAETVEERKIG--DDRMTFVMGCKN 153 >1SRV-A nrPDB Length = 145 Score = 68.1 bits (165), Expect = 1e-11, Method: Composition-based stats. Identities = 35/167 (20%), Positives = 63/167 (37%), Gaps = 36/167 (21%) Query: 222 TKLIKGVIVDKDFSHPQ-MPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKY 280 + KG I ++P+ M +EDA I I+ + V++V + + Sbjct: 2 YQFDKGYISPYFVTNPETMEAVLEDAFILIV-------------EKKVSNVRELLPI--- 45 Query: 281 EKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLP------AVRWVGGPE----- 329 ++Q+ +TG L I + EA L+ N L AV+ G + Sbjct: 46 --------LEQVAQTGKPLLIIAEDVEGEALATLVVNKLRGTLSVAAVKAPGFGDRRKEM 97 Query: 330 IELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQ 376 ++ IA TGG ++ E + L + TKD+ ++ Sbjct: 98 LKDIAAVTGGTVISEELGFKLENATLSMLGRAERVRITKDETTIVGG 144 >1KID-A nrPDB Length = 203 Score = 66.2 bits (160), Expect = 4e-11, Method: Composition-based stats. Identities = 35/190 (18%), Positives = 67/190 (35%), Gaps = 32/190 (16%) Query: 226 KGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKF 285 +G+ D+ + P K E + L PF ++++ + + Sbjct: 18 EGMQFDRGYLSPYFINKPETGAVE-LESPFILL-----ADKKISNIREMLPV-------- 63 Query: 286 EEMIQQIKETGANLAICQWGFDDEANHLLLQN------NLPAVRWVGGPE-----IELIA 334 ++ + + G L I + EA L+ N + AV+ G + ++ IA Sbjct: 64 ---LEAVAKAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIA 120 Query: 335 IATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMI 394 TGG ++ + EK L Q KD +I+ A I+G I Sbjct: 121 TLTGGTVISEEIGMELEKATLEDLGQAKRVVINKDTTTIIDGVGEEAA----IQGRVAQI 176 Query: 395 IEEAKRSLHD 404 ++ + + D Sbjct: 177 RQQIEEATSD 186 >1DKD-A nrPDB Length = 146 Score = 62.3 bits (150), Expect = 6e-10, Method: Composition-based stats. Identities = 30/162 (18%), Positives = 57/162 (35%), Gaps = 28/162 (17%) Query: 226 KGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKF 285 +G+ D+ + P K E + L PF ++++ + + Sbjct: 1 EGMQFDRGYLSPYFINKPETGAVE-LESPFILL-----ADKKISNIREMLPV-------- 46 Query: 286 EEMIQQIKETGANLAICQWGFDDEANHLLLQN------NLPAVRWVGGPE-----IELIA 334 ++ + + G L I + EA L+ N + AV+ G + ++ IA Sbjct: 47 ---LEAVAKAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIA 103 Query: 335 IATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQ 376 TGG ++ + EK L Q KD +I+ Sbjct: 104 TLTGGTVISEEIGMELEKATLEDLGQAKRVVINKDTTTIIDG 145 >3OSX-A nrPDB Length = 201 Score = 59.2 bits (142), Expect = 5e-09, Method: Composition-based stats. Identities = 27/169 (15%), Positives = 56/169 (33%), Gaps = 28/169 (16%) Query: 226 KGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKF 285 +G+ D+ + P K E + + ++++ + + Sbjct: 13 EGMQFDRGYLSPYFINKPESGSVELENPYI------LLVDKKISNIRELLPV-------- 58 Query: 286 EEMIQQIKETGANLAICQWGFDDEANHLLLQNN------LPAVRWVGGPE-----IELIA 334 ++ + + L I + EA L+ NN + +V+ G + ++ IA Sbjct: 59 ---LEGVAKASKPLVIIAEDVEGEALATLVVNNMRGIVKVASVKAPGFGDRRKAMLQDIA 115 Query: 335 IATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAV 383 T G ++ L EK L Q KD +I+ A+ Sbjct: 116 TLTNGTVISEEIGLELEKATLEDLGQAKRVVINKDTTTIIDGVGEEGAI 164 >3M6C-A nrPDB Length = 194 Score = 52.7 bits (125), Expect = 4e-07, Method: Composition-based stats. Identities = 32/195 (16%), Positives = 68/195 (34%), Gaps = 32/195 (16%) Query: 221 DTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKY 280 + + +G+ DK F ++ + + + K D+ + Sbjct: 1 ELEFTEGIGFDKGFLSAYFVTDFDNQQAVLEDALILLHQDKISSLPDLLPLL-------- 52 Query: 281 EKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNL------PAVRWVGGPE----- 329 +++ TG L I + EA L+ N + AV+ + Sbjct: 53 ---------EKVAGTGKPLLIVAEDVEGEALATLVVNAIRKTLKAVAVKGPYFGDRRKAF 103 Query: 330 IELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRG 389 +E +A+ TGG++V + + ++G L +KD ++++ + AV Sbjct: 104 LEDLAVVTGGQVVNPDAGMVLREVGLEVLGSARRVVVSKDDTVIVDGGGTAEAVA----N 159 Query: 390 GNKMIIEEAKRSLHD 404 K + E +S D Sbjct: 160 RAKHLRAEIDKSDSD 174 >5CDK-A nrPDB Length = 183 Score = 48.4 bits (114), Expect = 7e-06, Method: Composition-based stats. Identities = 27/157 (17%), Positives = 57/157 (36%), Gaps = 20/157 (12%) Query: 222 TKLIKGVIVDKDFSHPQ-MPKKVEDAKIAILTCPFEPPK---PKTKHKLDVTSVEDYKAL 277 ++ +G + P+ M + E+ KI ++ + + + A Sbjct: 1 SQFERGYTSPYFVTDPERMICEYENCKILLVDKKISTARDIITILESAIRGNYPLLIMAE 60 Query: 278 QKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIAT 337 + ++ ++ +++ T +AI GF + + L E IAI T Sbjct: 61 EVEQEALATLVVNKLRGTLKVVAIKAPGFGERRSSYL----------------EDIAILT 104 Query: 338 GGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVI 374 GG +V ++ E+ A L TK++ V+ Sbjct: 105 GGTVVRDEMGVSLEQATDAVLGTAAKITITKERTTVV 141 >3LXD-A nrPDB Length = 415 Score = 40.0 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 34/213 (15%), Positives = 67/213 (31%), Gaps = 36/213 (16%) Query: 308 DEANHLLLQNNLP---AVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISF 364 + L + +R E + + + G +V KLG ++ Sbjct: 52 PLSKEYLAREKTFERICIRPAQFWEDKAVEMKLGAEVVSLDPAAHTVKLGDGSAIE---- 107 Query: 365 GTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDA--LCVIRNLIRDNRVVYGG 422 K++ + R ++ G + A R+ DA L + N VV GG Sbjct: 108 ---YGKLIWATGG-DPRRLSCV---GADLAGVHAVRTKEDADRLMAELDAGAKNAVVIGG 160 Query: 423 GAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQV 482 G + A +++ LE +P L+ +G + ++E Sbjct: 161 GYIGLEAAAVLTKFGVNVT------------LLEALPRVLARVAG----EALSEFY---- 200 Query: 483 KEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQ 515 + + A G+D D + + + Q Sbjct: 201 QAEHRAHGVDLRTGAAMDCIEGDGTKVTGVRMQ 233 >5CDJ-A nrPDB Length = 186 Score = 38.8 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 27/173 (15%), Positives = 52/173 (30%), Gaps = 28/173 (16%) Query: 226 KGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKF 285 +G+ +D+ + PQ E + C + ++ D + Sbjct: 2 EGMEIDRGYISPQFVTNQERLLVEYDNCRVLV------TDQKIDAIRDIIPI-------- 47 Query: 286 EEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWV-----------GGPEIELIA 334 ++Q+ A L I EA L+ N L V V ++ IA Sbjct: 48 ---LEQVTRLNAPLLIIAEDVSGEALATLVVNKLRGVLNVCAIKAPGFGERRKSLLQDIA 104 Query: 335 IATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFI 387 I TG + + + E+ L + +I + + + I Sbjct: 105 IVTGAEFIAKDLGMKVEQAVVEQLGVARKVTVANNTTTLIADAASKDEIEMRI 157 >3E0V-A nrPDB Length = 539 Score = 35.7 bits (81), Expect = 0.047, Method: Composition-based stats. Identities = 17/76 (22%), Positives = 34/76 (44%), Gaps = 12/76 (15%) Query: 28 LMGLEALKSH-IMAAKAVANTMRTSLGPNGLDKMM---------VDKDGDVTVTNDGATI 77 G++ + + I +A+ V + +R +LGP G D M+ V + +DG + Sbjct: 243 EQGVDMIFASFIRSAEQVGD-VRKALGPKGRDIMIICKIENHQGVQNIDSIIEESDGIMV 301 Query: 78 LS-MMDVDHQIAKLMV 92 + V+ K++V Sbjct: 302 ARGDLGVEIPAEKVVV 317 >4G1T-A nrPDB Length = 472 Score = 34.2 bits (77), Expect = 0.15, Method: Composition-based stats. Identities = 26/138 (18%), Positives = 52/138 (37%), Gaps = 13/138 (9%) Query: 182 HRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVG--GRLEDTKLIKGVIVDKDFSHPQM 239 R++ E+ +AV + + + + L +V + L D K+FS Sbjct: 309 KRKLLELIGHAVAHLK--KADEANDNLFRVCSILASLHALADQYEEAEYYFQKEFSKELT 366 Query: 240 PKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQK--YEKEKFEEMIQQIKETGA 297 P + + K + K + + + + EKEK ++ +Q+I + Sbjct: 367 PVAKQLLHLRYGNFQLYQMKCEDKA---IHHFIEGVKINQKSREKEKMKDKLQKIAKMR- 422 Query: 298 NLAICQWGFDDEANHLLL 315 + + G D EA H+L Sbjct: 423 ---LSKNGADSEALHVLA 437 >3L6X-A nrPDB Length = 584 Score = 33.4 bits (75), Expect = 0.29, Method: Composition-based stats. Identities = 15/55 (27%), Positives = 23/55 (41%), Gaps = 1/55 (1%) Query: 345 FSELTAE-KLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEA 398 E LG G ++ ISFG +D + I+ C A+ +R M + E Sbjct: 99 LDHPKKEVHLGACGALKNISFGRDQDNKIAIKNCDGVPALVRLLRKARDMDLTEV 153 >6ESQ-A nrPDB Length = 392 Score = 33.0 bits (74), Expect = 0.31, Method: Composition-based stats. Identities = 15/73 (20%), Positives = 26/73 (35%), Gaps = 1/73 (1%) Query: 175 SKVVNSCHRQMAEIAVNA-VLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKD 233 +K ++ V A V + D D + + + GG + I +I D Sbjct: 12 TKFGELWEDSFRDLIVEAGVKAIKDANVDGGDIDAMYIGNMSGGLFVGQEHIASLIADHA 71 Query: 234 FSHPQMPKKVEDA 246 +P +VE A Sbjct: 72 GLNPVPCTRVEAA 84 >3BWN-A nrPDB Length = 391 Score = 33.0 bits (74), Expect = 0.37, Method: Composition-based stats. Identities = 19/79 (24%), Positives = 32/79 (40%), Gaps = 15/79 (18%) Query: 378 KNSRAVTIFIRGG------NKMI-----IE-EAKRSLHDALCVIRN-LIRDNRVVYGGGA 424 K T+ IRG + M +E E + ++ D V+ N D +V G G+ Sbjct: 41 KMGDRCTVTIRGCDLMSYFSDMTNLCWFLEPELEDAIKDLHGVVGNAATEDRYIVVGTGS 100 Query: 425 AEI--SCALAVSQEADKCP 441 ++ + A+S A P Sbjct: 101 TQLCQAAVHALSSLARSQP 119 >5H12-A nrPDB Length = 775 Score = 32.3 bits (72), Expect = 0.53, Method: Composition-based stats. Identities = 32/161 (19%), Positives = 60/161 (37%), Gaps = 14/161 (8%) Query: 191 NAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAI 250 +AV+ + + + LI E+ KL + D + + + + + I I Sbjct: 104 SAVIDIFEYDIPFAKRYLIDKGLIPMEGDEELKL---LAFDIETLYHEGEEFAKGPIIMI 160 Query: 251 LTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEA 310 E K T K+D+ VE + E+E + ++ I+E ++ I G D Sbjct: 161 SYADEEEAKVITWKKIDLPYVE----VVSSEREMIKRFLKVIREKDPDVIITYNG-DSFD 215 Query: 311 NHLLLQN------NLPAVRWVGGPEIELIAIATGGRIVPRF 345 L++ LP R P+++ + T I R Sbjct: 216 LPYLVKRAEKLGIKLPLGRDGSEPKMQRLGDMTAVEIKGRI 256 >4FLV-A nrPDB Length = 793 Score = 31.5 bits (70), Expect = 0.89, Method: Composition-based stats. Identities = 30/145 (20%), Positives = 59/145 (40%), Gaps = 11/145 (7%) Query: 195 TVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCP 254 V D+ D+ F + K +E + + + VD + + + + + I I Sbjct: 127 AVVDIFEYDIPFAKRYLIDKGLTPMEGNEELTFLAVDIETLYHEGEEFGKGPIIMISYAD 186 Query: 255 FEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLL 314 E K T +D+ VE + E+E + +++ I+E ++ I G D+ A L Sbjct: 187 EEGAKVITWKSIDLPYVE----VVSSEREMIKRLVKVIREKDPDVIITYNG-DNFAFPYL 241 Query: 315 LQN------NLPAVRWVGGPEIELI 333 L+ LP R P+++ + Sbjct: 242 LKRAEKLGIKLPLGRDNSEPKMQRM 266 >4UZY-A nrPDB Length = 651 Score = 31.1 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 41/198 (20%), Positives = 74/198 (37%), Gaps = 11/198 (5%) Query: 149 DKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFEL 208 K +D+V E L A +K + +AEI AV ++ + + Sbjct: 168 QKFNDAVQALGYQPELLYNIALCYYKTKQFGPALKHLAEIIEKAVREHPELSVGS-NTDG 226 Query: 209 IKVEGKVGG-RLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLD 267 ++V L++T LI+ + + K VE AK A+ P + L Sbjct: 227 MEVRSVGNSQTLKETALIE--AFNLKAAIEYTMKNVEAAKEALTDMPPRAEEELDPVTLH 284 Query: 268 VTSVEDYKALQKYEKEKFEEMIQQ---IKETGANLAIC----QWGFDDEANHLLLQNNLP 320 +++ + + +K ++Q ET ANL + GF D A +L +N Sbjct: 285 NSALINMDSDPTGGFKKLNFLLQSPPFPPETFANLLLLYCKPSHGFYDLAADVLAENPQY 344 Query: 321 AVRWVGGPEIELIAIATG 338 A + + + + A G Sbjct: 345 AGKLLSPDLYDYLQAAIG 362 >1FX7-A nrPDB Length = 230 Score = 30.7 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 18/107 (16%), Positives = 31/107 (28%), Gaps = 9/107 (8%) Query: 323 RWVGGPEIEL-IAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSR 381 V ++E + F G L G ++ + + Sbjct: 105 EHVMSEDVERRLVKVLNNPTTSPFGNPIP---GLDELGVGPEPGADDANLVRLTELPAGS 161 Query: 382 AVTIFIRGGNKMI---IEEAKRSLHDALCVIRNLIRDNRVVYGGGAA 425 V + +R + + I+ R L DA V+ N GGG Sbjct: 162 PVAVVVRQLTEHVQGDIDLITR-LKDA-GVVPNARVTVETTPGGGVT 206 >3D31-A nrPDB Length = 348 Score = 30.7 bits (68), Expect = 1.7, Method: Composition-based stats. Identities = 34/215 (15%), Positives = 65/215 (30%), Gaps = 38/215 (17%) Query: 243 VEDAKIAILTCPFEPPKPKTKHKLD-----VTSVEDYKAL----QKYEKEKFEEMIQ--- 290 V + KI +L P P+T+ + L + E + I Sbjct: 143 VTNPKILLLDEPLSALDPRTQENAREMLSVLHKKNKLTVLHITHDQTEARIMADRIAVVM 202 Query: 291 --QIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSEL 348 ++ + G I + + R E + GR++ L Sbjct: 203 DGKLIQVGKPEEIFEKPVEG--------------RVASFVGFENVLK---GRVISAEQGL 245 Query: 349 TAEKLGFA--GLVQEISFGTTKDKMLVIEQCKNSRAVT-IFIRGGNKMIIEEAKRSLHDA 405 ++G ++ G L E S++ T IR + + EA + A Sbjct: 246 LRIRVGEVVIDAAGDMEVGDQVYAFLRPENIALSKSSTQSSIRNSLQGRVTEA--WVLGA 303 Query: 406 LCVIR--NLIRDNRVVYGGGAAEISCALAVSQEAD 438 L ++ + N ++ A E+ + V A Sbjct: 304 LVRVKVDCGVPLNVLITRRSAEEMELSPGVQIYAR 338 >2H6E-A nrPDB Length = 344 Score = 30.3 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 20/110 (18%), Positives = 36/110 (32%), Gaps = 24/110 (21%) Query: 92 VELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKI 151 VE + D GTT + GA+ +A + + P+ I +G A I+ L + Sbjct: 143 VEAAPLADA----GTTSM----GAI-RQALPFISKFAEPVVIVNGIGGLAVYTIQILKAL 193 Query: 152 SDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMER 201 ++ + K E+ + V + D E Sbjct: 194 MKNIT-----------IVGISRSKK----HRDFALELGADYVSEMKDAES 228 >4KRZ-A nrPDB Length = 519 Score = 30.3 bits (67), Expect = 2.4, Method: Composition-based stats. Identities = 12/83 (14%), Positives = 33/83 (39%), Gaps = 10/83 (12%) Query: 20 KDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGD---------VTV 70 ++ + G++ + + + +R +LG G D +++ K + + Sbjct: 215 REDLKFGVEQGIDMVFASFIRTAEQVQEVREALGEKGKDILIISKIENHQGVQNIDGIIE 274 Query: 71 TNDGATILS-MMDVDHQIAKLMV 92 +DG + + V+ K++V Sbjct: 275 ASDGIMVARGDLGVEIPAEKVVV 297 >2GJN-A nrPDB Length = 328 Score = 29.9 bits (66), Expect = 2.6, Method: Composition-based stats. Identities = 23/84 (27%), Positives = 32/84 (38%), Gaps = 6/84 (7%) Query: 357 GLVQEISFGTT----KDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNL 412 GLV ++ G + L +C AV IR ++ + RSL + V RN Sbjct: 186 GLVAALALGADAINMGTRFLATRECPIHPAVKAAIRAADERSTDLIMRSLRNTARVARNA 245 Query: 413 IRDNRVV--YGGGAAEISCALAVS 434 I + GGA A VS Sbjct: 246 ISQEVLAIEARGGAGYADIAALVS 269 >2VWK-A nrPDB Length = 773 Score = 29.9 bits (66), Expect = 2.7, Method: Composition-based stats. Identities = 25/123 (20%), Positives = 48/123 (39%), Gaps = 5/123 (4%) Query: 195 TVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCP 254 V D+ D+ F + K +E + +K + D + + + K E + I Sbjct: 105 AVVDIYEYDIPFAKRYLIDKGLIPMEGDEELKMLAFDIETLYHEGEKFAEGPILMISYAD 164 Query: 255 FEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLL 314 E + T +D+ Y + EKE + ++ +KE ++ I G D+ A L Sbjct: 165 EEGARVITWRNIDLP----YVDVVSTEKEMIKRFLKVVKEKDPDVLITYNG-DNFAFAYL 219 Query: 315 LQN 317 + Sbjct: 220 KKR 222 >1S5J-A nrPDB Length = 847 Score = 29.6 bits (65), Expect = 3.9, Method: Composition-based stats. Identities = 14/97 (14%), Positives = 34/97 (35%) Query: 237 PQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETG 296 P MP V++ K+ + + + K S E + + FE I +IK Sbjct: 135 PGMPYVVKNGKLESVYLSLDEKDVEEIKKAFADSDEMTRQMAVDWLPIFETEIPKIKRVA 194 Query: 297 ANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELI 333 ++ + + + + ++ G ++ + Sbjct: 195 IDIEVYTPVKGRIPDSQKAEFPIISIALAGSDGLKKV 231 >2OF3-A nrPDB Length = 266 Score = 29.6 bits (65), Expect = 4.0, Method: Composition-based stats. Identities = 16/89 (17%), Positives = 34/89 (38%), Gaps = 23/89 (25%) Query: 14 RPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDG------- 66 P+L++K EA + + + + N + +GP + M++D Sbjct: 134 VPYLLLKTG---------EAKDNMRTSVRDIVNVLSDVVGPLKMTPMLLDALKSKNARQR 184 Query: 67 -------DVTVTNDGATILSMMDVDHQIA 88 + +TN G + L + V+ +A Sbjct: 185 SECLLVIEYYITNAGISPLKSLSVEKTVA 213 >2GF2-A nrPDB Length = 296 Score = 29.6 bits (65), Expect = 4.0, Method: Composition-based stats. Identities = 19/108 (17%), Positives = 40/108 (37%), Gaps = 1/108 (0%) Query: 122 QLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSC 181 + L + +P+ I D + A + + +++ S + + +I T++ + S Sbjct: 17 KNLMKHGYPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIITMLPTSINAIEAYSG 76 Query: 182 HRQMAEIAVNAVLTVADMER-RDVDFELIKVEGKVGGRLEDTKLIKGV 228 + + L + V EL K K+G D + GV Sbjct: 77 ANGILKKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMDAPVSGGV 124 >1V72-A nrPDB Length = 356 Score = 29.2 bits (64), Expect = 4.9, Method: Composition-based stats. Identities = 15/47 (31%), Positives = 24/47 (51%), Gaps = 4/47 (8%) Query: 63 DKDGDVTVTNDGATILSMMDVDHQIAKL-MVELSKSQDDEIGDGTTG 108 D+ G ++GA +M VD AKL +V L + +++GD T Sbjct: 97 DECGAPEFFSNGA---KLMTVDGPAAKLDIVRLRERTREKVGDVHTT 140 >5U7X-F nrPDB Length = 437 Score = 28.8 bits (63), Expect = 5.6, Method: Composition-based stats. Identities = 16/102 (15%), Positives = 37/102 (36%), Gaps = 9/102 (8%) Query: 116 LLEEAEQLLDRGIHPIR-----IADGYEQ----AARVAIEHLDKISDSVLVDIKDTEPLI 166 LLEEAE ++ +HP G AA ++ + ++ + + + Sbjct: 87 LLEEAEDVVPEELHPKTPLKLGATAGLRLLDGDAAEKILQAVREMFRNRSSLSVQPDAVS 146 Query: 167 QTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFEL 208 T GS + + + + ++ TV ++ ++ Sbjct: 147 VIDGTQEGSYLWVTVNYLLGKLGKKFTKTVGVIDLGGASVQM 188 >4XFK-A nrPDB Length = 399 Score = 28.8 bits (63), Expect = 6.4, Method: Composition-based stats. Identities = 22/143 (15%), Positives = 49/143 (34%), Gaps = 32/143 (22%) Query: 396 EEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADAL 455 + K ++ D +I + + V G V + + E + A+AL Sbjct: 69 DRVKAAIADGAQII--VQGSSSAVAG------QITEDVRKYNLRNKGKEVLYLNLGAEAL 120 Query: 456 E------------------VIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKG 497 E + +++ GM + E RA + + N + G+D + Sbjct: 121 ELTGSKCHFYHFRFSPNAAIRFKTVAQ--GMKDKGILGE-RAYSINQ-NYSWGVDVENTV 176 Query: 498 TNDMKQQH--VIETLIGKKQQIS 518 + K+ V++ + + +I Sbjct: 177 VANAKEIGYEVVDKTLHEVNKIQ 199 >2QS8-A nrPDB Length = 418 Score = 28.4 bits (62), Expect = 8.6, Method: Composition-based stats. Identities = 13/57 (22%), Positives = 23/57 (40%), Gaps = 2/57 (3%) Query: 478 RARQVKEMNPALGIDCLHKGTNDMKQQHV--IETLIGKKQQISLATQMVRMILKIDD 532 R K + A G D + ++ V +E + + I AT +L+I+D Sbjct: 314 RKAYEKGVKIAFGTDAGVQKHGTNWKEFVYMVENGMPAMKAIQSATMETAKLLRIED 370 >1Q1R-A nrPDB Length = 431 Score = 28.4 bits (62), Expect = 8.9, Method: Composition-based stats. Identities = 16/32 (50%), Positives = 20/32 (62%), Gaps = 1/32 (3%) Query: 400 RSLHDALCVIRNLIRDNRVVY-GGGAAEISCA 430 R+L DA C+ R LI DNR+V GGG + A Sbjct: 134 RTLEDAECIRRQLIADNRLVVIGGGYIGLEVA 165 >3GEE-A nrPDB Length = 476 Score = 28.0 bits (61), Expect = 9.6, Method: Composition-based stats. Identities = 14/82 (17%), Positives = 27/82 (32%), Gaps = 12/82 (14%) Query: 73 DGATILSMMDVDHQIAKLMVELSKSQDDEI---------GDGTTGVVVLAGALLEEAEQL 123 D T + + H AK + ++ D DGT V+ AL + Sbjct: 329 DELTEIRELKAAHPAAKFLT-VANKLDRAANADALIRAIADGTGTEVIGISALNGDGIDT 387 Query: 124 LDRGIHPIRIADGYEQAARVAI 145 L + H + ++ ++ Sbjct: 388 LKQ--HMGDLVKNLDKLHEASV 407 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.142 0.362 Lambda K H 0.267 0.0438 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 19,321,669 Number of Sequences: 36641 Number of extensions: 809250 Number of successful extensions: 3021 Number of sequences better than 10.0: 80 Number of HSP's better than 10.0 without gapping: 88 Number of HSP's successfully gapped in prelim test: 47 Number of HSP's that attempted gapping in prelim test: 2631 Number of HSP's gapped (non-prelim): 151 length of query: 541 length of database: 10,336,785 effective HSP length: 102 effective length of query: 439 effective length of database: 6,599,403 effective search space: 2897137917 effective search space used: 2897137917 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 62 (28.4 bits)