BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P47079 (568 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5GW5-q nrPDB 1159 0.0 4B2T-Q nrPDB 470 e-133 1Q3S-A nrPDB 265 3e-71 1A6E-A nrPDB 256 2e-68 3RUW-A nrPDB 242 3e-64 3J1C-A nrPDB 237 8e-63 4XCI-A nrPDB 234 1e-61 3J1E-A nrPDB 224 7e-59 3AQ1-B nrPDB 223 3e-58 4XCG-B nrPDB 222 3e-58 1A6D-B nrPDB 216 3e-56 3IYF-A nrPDB 214 7e-56 5GW4-h nrPDB 197 1e-50 5UYZ-A nrPDB 196 2e-50 4B2T-H nrPDB 195 5e-50 4B2T-D nrPDB 190 1e-48 4B2T-A nrPDB 189 3e-48 5GW5-g nrPDB 186 2e-47 4V8R-AE nrPDB 186 2e-47 4B2T-G nrPDB 184 7e-47 5GW4-d nrPDB 184 1e-46 4V94-A nrPDB 177 1e-44 4B2T-Z nrPDB 174 8e-44 5GW5-z nrPDB 152 5e-37 4B2T-B nrPDB 146 2e-35 4V8R-AB nrPDB 139 4e-33 4V8R-AG nrPDB 127 1e-29 5X9V-A nrPDB 118 6e-27 1ASS-A nrPDB 69 4e-12 1E0R-B nrPDB 63 3e-10 1GN1-A nrPDB 53 4e-07 5CDI-A nrPDB 44 2e-04 5DA8-A nrPDB 42 5e-04 4PJ1-A nrPDB 39 0.007 4AAR-A nrPDB 39 0.007 1IOK-A nrPDB 37 0.034 4V4O-A nrPDB 33 0.48 5A1Y-E nrPDB 30 3.0 3BU8-A nrPDB 29 4.3 2Q8N-A nrPDB 29 4.9 3VSD-A nrPDB 29 5.1 5Y58-B nrPDB 29 5.2 5MDW-r nrPDB 29 6.3 4M7C-A nrPDB 28 8.4 3KLJ-A nrPDB 28 9.6 1NRX-A nrPDB 28 10.0 >5GW5-q nrPDB Length = 568 Score = 1159 bits (2997), Expect = 0.0, Method: Compositional matrix adjust. Identities = 568/568 (100%), Positives = 568/568 (100%) Query: 1 MSLRLPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLG 60 MSLRLPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLG Sbjct: 1 MSLRLPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLG 60 Query: 61 KIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISM 120 KIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISM Sbjct: 61 KIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISM 120 Query: 121 GLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGSEDILSE 180 GLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGSEDILSE Sbjct: 121 GLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGSEDILSE 180 Query: 181 LVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLS 240 LVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLS Sbjct: 181 LVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLS 240 Query: 241 EDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIV 300 EDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIV Sbjct: 241 EDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIV 300 Query: 301 AGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKT 360 AGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKT Sbjct: 301 AGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKT 360 Query: 361 MEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLL 420 MEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLL Sbjct: 361 MEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLL 420 Query: 421 PGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYA 480 PGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYA Sbjct: 421 PGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYA 480 Query: 481 AHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLS 540 AHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLS Sbjct: 481 AHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLS 540 Query: 541 IDQIIMAKKAGGPRAPQGPRPGNWDQED 568 IDQIIMAKKAGGPRAPQGPRPGNWDQED Sbjct: 541 IDQIIMAKKAGGPRAPQGPRPGNWDQED 568 >4B2T-Q nrPDB Length = 548 Score = 470 bits (1209), Expect = e-133, Method: Compositional matrix adjust. Identities = 258/569 (45%), Positives = 373/569 (65%), Gaps = 22/569 (3%) Query: 1 MSLRLPQNPN-AGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHL 59 M+L +P+ P A + K+G +S + + ++I A +EL Q T+ GP G NK+++NHL Sbjct: 1 MALHVPKAPGFAQMLKEGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHL 60 Query: 60 GKIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLIS 119 K+ +TNDAAT+LREL++ HPA K++VMA+ Q+ ++GDGTN V++ AG LL ++E+L+ Sbjct: 61 EKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLR 120 Query: 120 MGLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGSEDILS 179 +GLS E+I+GY +A K + L ++V + D +E+ ++ + SK+YG+E L+ Sbjct: 121 LGLSVSEVIEGYEIACKKAHEILPDLVCCSAKNLRDVDEVSSLLHTSVMSKQYGNEVFLA 180 Query: 180 ELVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSL 239 +L+++A + P + +FNVD+IRV KI+G + +S+V+ GMVF +E EG V S+ Sbjct: 181 KLIAQACVSIFP------DSGHFNVDNIRVCKILGSGVHSSSVLHGMVFKKETEGDVTSV 234 Query: 240 SEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECI 299 K K+AV++CP D TETKGTVL+ +A+E+++FSKGEE +DA +K IAD G + Sbjct: 235 ---KDAKIAVYSCPFDGMITETKGTVLIKSAEELMNFSKGEENLMDAQVKAIADTGANVV 291 Query: 300 VAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVK 359 V G V ++ALHY N+Y I+++++ SK++LRRLC+ GAT LPRL P EE+G ++V Sbjct: 292 VTGGRVADMALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLNPPVLEEMGHCDSVY 351 Query: 360 TMEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKL 419 E+G +V VFK E+ E STI+LRG+T N +DDIERA+DDGV K L + +L Sbjct: 352 LSEVGDTQVVVFKHEK-EDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDK--RL 408 Query: 420 LPGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLY 479 +PG GATEIEL +IT YGE PGL Q AIK+FA AFE +PR LAE +G+ NEV+ LY Sbjct: 409 VPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLY 468 Query: 480 AAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVL 539 A H G+DI+ E VKD+ E + D K +AI +AT AA TVL Sbjct: 469 AVHQEGNKNV--------GLDIEAEV-PAVKDMLEAGVLDTYLGKYWAIKLATNAAVTVL 519 Query: 540 SIDQIIMAKKAGGPRAPQGPRPGNWDQED 568 +DQIIMAK AGGP+ P G + + DQ D Sbjct: 520 RVDQIIMAKPAGGPKPPSGKKDWDEDQND 548 >1Q3S-A nrPDB Length = 548 Score = 265 bits (678), Expect = 3e-71, Method: Compositional matrix adjust. Identities = 175/538 (32%), Positives = 302/538 (56%), Gaps = 25/538 (4%) Query: 13 LFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATML 72 + +G Y D Q + +AA R + + T++GP G +K++V+ LG I++TND AT+L Sbjct: 11 ILPEGTQRYVGRDAQRLNILAA-RIIAETVRTTLGPKGMDKMLVDSLGDIVVTNDCATIL 69 Query: 73 RELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYN 132 ++D+ HPA K++V + Q + GDGT +++AGELL +E+L+ + II+GY Sbjct: 70 DKIDLQHPAAKMMVEVAKTQDKEAGDGTTTAVVIAGELLRKAEELLDQNIHPSIIIKGYA 129 Query: 133 MARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGS-EDILSELVSEAVSHVLP 191 +A + + LDE+ + D +D+ LLK+ I+ K S +++L++L EAV Sbjct: 130 LAAEKAQEILDEIAIR--VDPDDEETLLKIAATSITGKNAESHKELLAKLAVEAVKQ--- 184 Query: 192 VAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFT 251 VA++ ++D+I+ K G + S +++G+V ++E H + + K+A+ Sbjct: 185 VAEKKDGKYVVDLDNIKFEKKAGEGVEESELVRGVVIDKEV-VHPRMPKRVENAKIALIN 243 Query: 252 CPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGELALH 311 L++ TET + + + +++ F + EEK + M+ IA G + G+ +LA H Sbjct: 244 EALEVKKTETDAKINITSPDQLMSFLEQEEKMLKDMVDHIAQTGANVVFVQKGIDDLAQH 303 Query: 312 YLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGDRVTVF 371 YL +YGI+ ++ K ++ +L + GA + + TPE+LG E V+ ++ G+ + Sbjct: 304 YLAKYGIMAVRRVKKSDMEKLAKATGAKIVTNVKDLTPEDLGYAEVVEERKLAGENMIFV 363 Query: 372 KQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATEIELI 431 E + + TI++RG T++ +D++ERA++D V VK +M+ G +LP GA EIEL Sbjct: 364 --EGCKNPKAVTILIRGGTEHVIDEVERALEDAVKVVKDVME--DGAVLPAGGAPEIELA 419 Query: 432 SRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPGAVK 491 R+ +Y ++ G LAI+ FA A +++P+TLAE AGLD E+L + + H K Sbjct: 420 IRLDEYAKQVGGKEALAIENFADALKIIPKTLAENAGLDTVEMLVKVISEH--------K 471 Query: 492 TDHLYKGVDI-DGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQIIMAK 548 L G+D+ +G+ D+ E+ I + L KK AI A+EAA +L ID +I AK Sbjct: 472 NRGLGIGIDVFEGKP----ADMLEKGIIEPLRVKKQAIKSASEAAIMILRIDDVIAAK 525 >1A6E-A nrPDB Length = 545 Score = 256 bits (653), Expect = 2e-68, Method: Compositional matrix adjust. Identities = 179/540 (33%), Positives = 283/540 (52%), Gaps = 31/540 (5%) Query: 15 KQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRE 74 +QG N+ N +I A + + T++GP G +K++V+ +G III+ND AT+L+E Sbjct: 18 EQGKNAQRN-------NIEAAKAIADAVRTTLGPKGMDKMLVDSIGDIIISNDGATILKE 70 Query: 75 LDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNMA 134 +D+ HP K++V ++ Q +GDGT ++L+GELL +E L+ G+ I GY +A Sbjct: 71 MDVEHPTAKMIVEVSKAQDTAVGDGTTTAVVLSGELLKQAETLLDQGVHPTVISNGYRLA 130 Query: 135 RKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYG-SEDILSELVSEAVSHVLPVA 193 K +DE+ D L K+ +S K G S D L++LV +AV+ V V Sbjct: 131 VNEARKIIDEIA----EKSTDDATLRKIALTALSGKNTGLSNDFLADLVVKAVNAVAEVR 186 Query: 194 QQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFTCP 253 + N I+V K GGS++++ I G+V ++E + H K K K+A+ Sbjct: 187 DGKTIVDTAN---IKVDKKNGGSVNDTQFISGIVIDKE-KVHSKMPDVVKNAKIALIDSA 242 Query: 254 LDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGELALHYL 313 L+I TE + V + + ++ DF E M+++I G ++ G+ ++A HYL Sbjct: 243 LEIKKTEIEAKVQISDPSKIQDFLNQETNTFKQMVEKIKKSGANVVLCQKGIDDVAQHYL 302 Query: 314 NRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGDRVTVFKQ 373 + GI ++ K ++ +L + GA + L TP LG ETV+ +IG DR+T Sbjct: 303 AKEGIYAVRRVKKSDMEKLAKATGAKIVTDLDDLTPSVLGEAETVEERKIGDDRMTFVMG 362 Query: 374 EQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATEIELISR 433 + + +I++RG T + + ++ERA++D + V + GK L G GA E EL R Sbjct: 363 CKN--PKAVSILIRGGTDHVVSEVERALNDAIRVV--AITKEDGKFLWGGGAVEAELAMR 418 Query: 434 ITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPGAVKTD 493 + KY G QLAI+ FA A E++PRTLAE AG+D L L A E G + Sbjct: 419 LAKYANSVGGREQLAIEAFAKALEIIPRTLAENAGIDPINTLIKLKADD---EKGRISV- 474 Query: 494 HLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQIIMAKKAGGP 553 GVD+D + GV D++ + + D L K A+ A E AT +L ID +I +KK+ P Sbjct: 475 ----GVDLD---NNGVGDMKAKGVVDPLRVKTHALESAVEVATMILRIDDVIASKKSTPP 527 >3RUW-A nrPDB Length = 543 Score = 242 bits (617), Expect = 3e-64, Method: Compositional matrix adjust. Identities = 166/551 (30%), Positives = 302/551 (54%), Gaps = 31/551 (5%) Query: 5 LPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIII 64 + Q P G+ + Y D Q + +I A R + + +++GP G +K++V+ LG +++ Sbjct: 1 MSQQP--GVLPENMKRYMGRDAQRM-NILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVV 57 Query: 65 TNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSA 124 TND T+LRE+ + HPA K+L+ + Q+ ++GDGT +++AGELL +E+L+ + Sbjct: 58 TNDGVTILREMSVEHPAAKMLIEVAKTQEKEVGDGTTTAVVVAGELLRKAEELLDQNVHP 117 Query: 125 VEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSK-KYGSEDILSELVS 183 +++GY A + +EL + + E+ DK L K+ I+ K +++ L+E++ Sbjct: 118 TIVVKGYQAAAQKA-QELLKTIACEVG-AQDKEILTKIAMTSITGKGAEKAKEKLAEIIV 175 Query: 184 EAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDK 243 EAVS V+ G++ + D I++ K G S+ ++ +IKG++ ++E V + K Sbjct: 176 EAVSAVV---DDEGKV---DKDLIKIEKKSGASIDDTELIKGVLVDKE---RVSAQMPKK 226 Query: 244 --KHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVA 301 K+A+ C ++I TET + + + ++++F + EEK + M+ EI G + Sbjct: 227 VTDAKIALLNCAIEIKETETDAEIRITDPAKLMEFIEQEEKMLKDMVAEIKASGANVLFC 286 Query: 302 GAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTM 361 G+ +LA HYL + GI+ + K ++ +L + GA + + A + ++LG V+ Sbjct: 287 QKGIDDLAQHYLAKEGIVAARRVKKSDMEKLAKATGANVIAAIAALSAQDLGDAGLVEER 346 Query: 362 EIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLP 421 +I GD + E+ + + T+++RG T++ ++++ RA+DD V V ++ G+++ Sbjct: 347 KISGDSMIFV--EECKHPKAVTMLIRGTTEHVIEEVARAVDDAVGVVGCTIED--GRIVS 402 Query: 422 GAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAA 481 G G+TE+EL ++ +Y E G QLA++ FA A EV+PRTLAE AGLD E+L + AA Sbjct: 403 GGGSTEVELSMKLREYAEGISGREQLAVRAFADALEVIPRTLAENAGLDAIEILVKVRAA 462 Query: 482 HNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSI 541 H + +++ G V+D+ E + + L K AI A E+ +L I Sbjct: 463 H-ASNGNKCAGLNVFTG---------AVEDMCENGVVEPLRVKTQAIQSAAESTEMLLRI 512 Query: 542 DQIIMAKKAGG 552 D +I A+K G Sbjct: 513 DDVIAAEKLRG 523 >3J1C-A nrPDB Length = 563 Score = 237 bits (605), Expect = 8e-63, Method: Compositional matrix adjust. Identities = 164/544 (30%), Positives = 296/544 (54%), Gaps = 25/544 (4%) Query: 13 LFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATML 72 LFK+G + S D + +I A R L +M +S+GP G +K++++ G + ITND AT++ Sbjct: 9 LFKEGTSRNSGRDA-LKNNILAARTLAEMLRSSLGPKGLDKMLIDSFGDVTITNDGATIV 67 Query: 73 RELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYN 132 +E++I HPA K+LV A + Q ++GDGT ++LAG L +E L+ + II+G+ Sbjct: 68 KEMEIQHPAAKLLVEAAKAQDSEVGDGTTSAVVLAGLFLEKAESLVDQNIHPTIIIEGFK 127 Query: 133 MARKFTLKELDEMV----VGEITDKNDKNELLKMIKPVISSKKYGSEDILSELVSEAVSH 188 A +L+ L ++ V ++ ++ L K++ +SSK + L++++ + Sbjct: 128 KAFNKSLELLPQLATKVDVSDLNSATARDALKKIVYTTMSSKFMAEGEELNKIMDIVIDA 187 Query: 189 VLPVAQQAGEIPY-FNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKV 247 V VA+ + Y ++D I++ K GG++ +S +I+G+V ++E H +K K+ Sbjct: 188 VTTVAEPLPDGGYNVSLDLIKIDKKKGGTIEDSQLIRGIVLDKEVV-HAGMPRRVEKAKI 246 Query: 248 AVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGE 307 AV L++ E + + + ++ F E K + M+ ++A +G ++ G+ + Sbjct: 247 AVLDASLEVEKPEISAKISITSPDQIKAFLDEEAKYLKDMVDKLASIGANVVICQKGIDD 306 Query: 308 LALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGDR 367 +A H+L + GIL ++ + ++ +L + GA + + TPE+LG E V+ ++G D+ Sbjct: 307 IAQHFLAKRGILAVRRVKRSDIEKLEKALGARIISSIKDATPEDLGYAELVEERKVGNDK 366 Query: 368 VTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKG-LMKPSGGKLLPGAGAT 426 + E + + I+LRG+ LD+ ER+I+D + +++ LM+P ++PG GA Sbjct: 367 MVFI--EGAKNPKAVNILLRGSNDMALDEAERSINDALYSLRNILMEPY---IVPGGGAI 421 Query: 427 EIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTE 486 E+EL +R+ +Y G QLAI+ +A A E +P LAETAGL+ L +L A H Sbjct: 422 ELELSARLREYARSVGGKEQLAIEAYADALEEIPMILAETAGLEPISALMDLRARH---A 478 Query: 487 PGAVKTDHLYKGVD-IDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQII 545 G GVD I+G+ + DI N+ + + + + ATEAAT+++ ID +I Sbjct: 479 KGLTNC-----GVDVINGKI---IDDIYSINVVEPIRVTRQVLKSATEAATSIMKIDDLI 530 Query: 546 MAKK 549 A + Sbjct: 531 AASQ 534 >4XCI-A nrPDB Length = 559 Score = 234 bits (596), Expect = 1e-61, Method: Compositional matrix adjust. Identities = 167/541 (30%), Positives = 290/541 (53%), Gaps = 23/541 (4%) Query: 13 LFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATML 72 L K+G + + D + +I A + L +M +S+GP G +K++++ G + ITND AT++ Sbjct: 7 LLKEGTSRTTGRDA-LRNNILAAKTLAEMLRSSLGPKGLDKMLIDSFGDVTITNDGATIV 65 Query: 73 RELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYN 132 ++++I HPA K+LV A + Q ++GDGT ++LAG LL +E L+ + II+GY Sbjct: 66 KDMEIQHPAAKLLVEAAKAQDAEVGDGTTSAVVLAGALLEKAESLLDQNIHPTIIIEGYK 125 Query: 133 MARKFTLKELDEMVVG-EITDKND---KNELLKMIKPVISSKKYGSEDILSELVSEAVSH 188 A L+ L ++ +I D N ++ L K+ ++SK L++++ + Sbjct: 126 KAYNKALELLPQLGTRIDIKDLNSSVARDTLRKIAFTTLASKFIAEGAELNKIIDMVIDA 185 Query: 189 VLPVAQQAGEIPY-FNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKV 247 ++ VA+ Y ++D I++ K GGS+ +S ++KG+V ++E H K K+ Sbjct: 186 IVNVAEPLPNGGYNVSLDLIKIDKKKGGSIEDSVLVKGLVLDKEVV-HPGMPRRVTKAKI 244 Query: 248 AVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGE 307 AV L++ E + + + +++ F E K + M+ ++A +G ++ G+ + Sbjct: 245 AVLDAALEVEKPEISAKISITSPEQIKAFLDEESKYLKDMVDKLASIGANVVICQKGIDD 304 Query: 308 LALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGDR 367 +A H+L + GIL ++ + ++ +L + GA + + TPE+LG E V+ +G D+ Sbjct: 305 IAQHFLAKKGILAVRRVKRSDIEKLEKALGARIISSIKDATPEDLGYAELVEERRVGNDK 364 Query: 368 VTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKG-LMKPSGGKLLPGAGAT 426 + E + + I+LRG+ LD+ ER+I+D + A++ L++P +LPG GA Sbjct: 365 MVFI--EGAKNLKAVNILLRGSNDMALDEAERSINDALHALRNILLEPV---ILPGGGAI 419 Query: 427 EIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTE 486 E+EL ++ +Y G QLAI+ FA A E +P LAETAGL+ L +L A H Sbjct: 420 ELELAMKLREYARSVGGKEQLAIEAFADALEEIPLILAETAGLEAISSLMDLRARH---A 476 Query: 487 PGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQIIM 546 G T GVD+ G + V D+ NI + + K + ATEAAT +L ID +I Sbjct: 477 KGLSNT-----GVDVIG--GKIVDDVYALNIIEPIRVKSQVLKSATEAATAILKIDDLIA 529 Query: 547 A 547 A Sbjct: 530 A 530 >3J1E-A nrPDB Length = 553 Score = 224 bits (571), Expect = 7e-59, Method: Compositional matrix adjust. Identities = 160/541 (29%), Positives = 285/541 (52%), Gaps = 28/541 (5%) Query: 31 SIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVHPAVKVLVMATE 90 +IAA++ + + ++ GP G +K++V+ LG I ITND AT+L ++D+ HPA K+LV + Sbjct: 35 NIAAVKAVEEALKSTYGPRGMDKMLVDSLGDITITNDGATILDKMDLQHPAAKLLVQIAK 94 Query: 91 QQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNMARKFTLKELDEMVVGEI 150 Q + DGT +I +GEL+ +E L+ + II GY A + L+ + E+ + Sbjct: 95 GQDEETADGTKTAVIFSGELVKKAEDLLYKDVHPTIIISGYKKAEEVALQTIQEL--AQT 152 Query: 151 TDKNDKNELLKMIKPVISSKKY-GSEDILSELVSEAVSHVLPVAQQAGEIPYFNVDSIRV 209 ND + L K+ +SSK G+ + ++++V +AV+ VA+ G+ Y ++D+I++ Sbjct: 153 VSINDTDLLRKIAMTSLSSKAVAGAREYIADIVVKAVTQ---VAELRGDKWYVDLDNIQI 209 Query: 210 VKIMGGSLSNSTVIKGMVFNRE--PEGHVKSLSEDKKHKVAVFTCPLDIANTETKGTVLL 267 VK GGS++++ ++ G+V ++E G K L + K+A+ L++ E + + Sbjct: 210 VKKAGGSINDTQLVYGIVVDKEVVHPGMPKRL---ENAKIALIDASLEVEKPELDAEIRI 266 Query: 268 HNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGELALHYLNRYGILVLKVPSKF 327 ++ +M F EE I + +I G I+ G+ E+A YL + G+L ++ K Sbjct: 267 NDPTQMQKFLDEEENLIKEKVDKILATGANVIICQKGIDEVAQSYLAKKGVLAVRRAKKS 326 Query: 328 ELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGDRVTVFKQEQGEISRTSTIILR 387 +L +L R G + + + ++LG ++ ++G D++ E + ++ +I++R Sbjct: 327 DLEKLARATGGRVVSNIDEISEQDLGYASLIEERKVGEDKMVFV--EGAKNPKSISILIR 384 Query: 388 GATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATEIELISRITKYGERTPGLLQL 447 G + +D+ ERA+ D + V ++K G+ + G GA EIE+ ++ KY + G QL Sbjct: 385 GGLERLVDETERALRDALGTVADVIKD--GRAIAGGGAVEIEIAKKLRKYAPQVGGKEQL 442 Query: 448 AIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPGAVKTDHLYKGVDIDGESDE 507 A++ +A A E + L E AG D ++L L + H D LY G + Sbjct: 443 AVEAYANALESLVSILIENAGFDPIDLLMKLRSTHENENNKWYGID-LYAGQPV------ 495 Query: 508 GVKDIREENIYDMLATKKFAINVATEAATTVLSIDQIIMA-KKAGG-PRAPQGP-RPGNW 564 D+ ++ + + K AI ATEAAT VL ID ++ A KK+GG + P G +P Sbjct: 496 ---DMWQKGVIEPALVKMNAIKAATEAATLVLRIDDVVSAGKKSGGESKTPGGANKPSEE 552 Query: 565 D 565 D Sbjct: 553 D 553 >3AQ1-B nrPDB Length = 500 Score = 223 bits (567), Expect = 3e-58, Method: Compositional matrix adjust. Identities = 156/510 (30%), Positives = 279/510 (54%), Gaps = 25/510 (4%) Query: 54 IIVNHLGKIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNV 113 ++V+ +G I+ITND AT+L+E+DI HPA K++V ++ Q ++GDGT +L+GELL+ Sbjct: 1 MLVDSMGDIVITNDGATILKEMDIQHPAAKMIVEVSKTQDAEVGDGTTTAAVLSGELLSK 60 Query: 114 SEKLISMGLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYG 173 +E+LI G+ + I +GY A + +E+ E + I+ +D+ L+K+ I+ K G Sbjct: 61 AEELIMKGVHSTIISEGYRHAAE-KCREILETITIAIS-PDDEAALIKIAGTAITGK--G 116 Query: 174 SEDILSELVSEAVSHVLPVAQQAGEIPYFNV-DSIRVVKIMGGSLSNSTVIKGMVFNREP 232 +E +L + V V + ++ + NV ++I++ K GGS+ +S +I G+V ++E Sbjct: 117 AEAYKEKLSALTVKAVRSIVEEEEDGLKVNVLENIKIEKRAGGSIDDSELIDGLVIDKE- 175 Query: 233 EGHVKSLSEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIA 292 H + + K+ + +CP++ TE + + + +M F EEK + M +++ Sbjct: 176 RSHPNMPEKVENAKILLLSCPVEFRKTEVDSEIKITSPGQMQLFLDQEEKMMREMAEKVI 235 Query: 293 DMGVECIVAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEEL 352 G + G+ ++A +Y+ + GI ++ K +L+RL +V GAT + L T E++ Sbjct: 236 ASGANVVFCQKGIDDMAQYYIEKAGIYAVRRVKKSDLKRLSKVTGATIIQDLDQITTEDV 295 Query: 353 GLVETVKTMEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLM 412 G V+ E+ G ++T Q S+ T++L G T++ +D ++ A++D + V ++ Sbjct: 296 GTAGLVEEKEVRGGKMTYVTGCQN--SKAVTVLLHGGTEHVVDSLDHALNDALHVVGVVI 353 Query: 413 KPSGGKLLPGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVN 472 + GK++ G G++E+EL R+++Y G QLA+ +FA A EV+P LAE AGLD Sbjct: 354 ED--GKVVVGGGSSEVELSLRLSEYASTLKGREQLAVSKFAEALEVIPVALAENAGLDPI 411 Query: 473 EVLPNLYAAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVAT 532 +++ L + H A ++Y G V D+ E ++ + L K AIN A Sbjct: 412 DIMVELRSQHEKGNKNA--GLNVYTG---------EVVDMWENDVIEPLRIKTQAINAAM 460 Query: 533 EAATTVLSIDQIIMAKKAGGPRAPQGPRPG 562 EA +L ID ++ +K + A QG PG Sbjct: 461 EATVMILRIDDVVASKGS----ANQGMGPG 486 >4XCG-B nrPDB Length = 557 Score = 222 bits (566), Expect = 3e-58, Method: Compositional matrix adjust. Identities = 160/529 (30%), Positives = 281/529 (53%), Gaps = 22/529 (4%) Query: 31 SIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVHPAVKVLVMATE 90 +IAA++ + + ++ GP G +K++V+ LG I ITND AT+L ++D+ HP K+LV + Sbjct: 37 NIAAVKAIEEALKSTYGPRGMDKMLVDSLGDITITNDGATILDKMDLQHPTGKLLVQIAK 96 Query: 91 QQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNMARKFTLKELDEMVVGEI 150 Q + DGT +ILAGEL +E L+ + I+ GY A + LK + E + + Sbjct: 97 GQDEETADGTKTAVILAGELAKKAEDLLYKEIHPTIIVSGYKKAEEIALKTIQE--IAQP 154 Query: 151 TDKNDKNELLKMIKPVISSKKY-GSEDILSELVSEAVSHVLPVAQQAGEIPYFNVDSIRV 209 ND + L K+ + SK G+ + L++LV +AV+ VA+ G+ Y ++D++++ Sbjct: 155 VTINDTDVLRKVALTSLGSKAVAGAREYLADLVVKAVAQ---VAELRGDKWYVDLDNVQI 211 Query: 210 VKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFTCPLDIANTETKGTVLLHN 269 VK GGS++++ ++ G+V ++E H + K+A+ L++ E + +++ Sbjct: 212 VKKHGGSVNDTQLVYGIVVDKEVV-HPGMPKRIENAKIALLDASLEVEKPELDAEIRIND 270 Query: 270 AQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGELALHYLNRYGILVLKVPSKFEL 329 +M F + EE + + +IA G ++ G+ E+A HYL + GIL ++ K +L Sbjct: 271 PTQMHKFLEEEENILKEKVDKIAATGANVVICQKGIDEVAQHYLAKKGILAVRRAKKSDL 330 Query: 330 RRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGDRVTVFKQEQGEISRTSTIILRGA 389 +L R G + + T ++LG V+ ++G D++ E + ++ +I++RG Sbjct: 331 EKLARATGGRVISNIDELTSQDLGYAALVEERKVGEDKMVFV--EGAKNPKSVSILIRGG 388 Query: 390 TQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATEIELISRITKYGERTPGLLQLAI 449 + +D+ ERA+ D + V +++ G+ + G GA EIE+ R+ KY + G QLAI Sbjct: 389 LERVVDETERALRDALGTVADVIRD--GRAVAGGGAVEIEIAKRLRKYAPQVGGKEQLAI 446 Query: 450 KQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPGAVKTDHLYKGVDIDGESDEGV 509 + +A A E + LAE AGLD + L L + H +T+ Y G+++ + E Sbjct: 447 EAYANAIEGLIMILAENAGLDPIDKLMQLRSLHE------NETNKWY-GLNLFTGNPE-- 497 Query: 510 KDIREENIYDMLATKKFAINVATEAATTVLSIDQIIMAKKAGGPRAPQG 558 D+ + + + K A+ ATEA T VL ID I+ A K G P G Sbjct: 498 -DMWKLGVIEPALVKMNAVKAATEAVTLVLRIDDIVAAGKKSGSE-PSG 544 >1A6D-B nrPDB Length = 543 Score = 216 bits (549), Expect = 3e-56, Method: Compositional matrix adjust. Identities = 166/538 (30%), Positives = 289/538 (53%), Gaps = 31/538 (5%) Query: 13 LFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATML 72 + K+G S D + ++I A + +S+GP G +K++V+ LG I+ITND T+L Sbjct: 9 ILKEGTKRESGKDA-MKENIEAAIAISNSVRSSLGPRGMDKMLVDSLGDIVITNDGVTIL 67 Query: 73 RELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYN 132 +E+D+ HPA K++V ++ Q +GDGT +I+AG LL ++ LI+ + I +GY Sbjct: 68 KEMDVEHPAAKMMVEVSKTQDSFVGDGTTTAVIIAGGLLQQAQGLINQNVHPTVISEGYR 127 Query: 133 MARKFTLKELDEMVVGEITDK---NDKNELLKMIKPVISSKKYG-SEDILSELVSEAVSH 188 MA E + V+ EI+ K ++K LLKM + ++SK ++D L+E+ EAV Sbjct: 128 MA-----SEEAKRVIDEISTKIGADEKALLLKMAQTSLNSKSASVAKDKLAEISYEAVK- 181 Query: 189 VLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVA 248 VA+ Y + D+I+VVK GG++ ++ +I G++ ++E + H K K+A Sbjct: 182 --SVAELRDGKYYVDFDNIQVVKKQGGAIDDTQLINGIIVDKE-KVHPGMPDVVKDAKIA 238 Query: 249 VFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGEL 308 + PL+I E + + + + F EE + M+ +I +G ++ G+ ++ Sbjct: 239 LLDAPLEIKKPEFDTNLRIEDPSMIQKFLAQEENMLREMVDKIKSVGANVVITQKGIDDM 298 Query: 309 ALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGDRV 368 A HYL+R GI ++ K ++ +L + GA+ + + + +LG E V+ +++G D + Sbjct: 299 AQHYLSRAGIYAVRRVKKSDMDKLAKATGASIVSTIDEISSSDLGTAERVEQVKVGEDYM 358 Query: 369 TVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATEI 428 T + + +I++RG T++ +D++ER+I D + V ++ GA A EI Sbjct: 359 TFVTGCKN--PKAVSILVRGETEHVVDEMERSITDSLHVVASALEDGAYAAGGGATAAEI 416 Query: 429 ELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPG 488 R+ Y ++ G QLAI++FA A E +PR LAE AGLD ++L L A H Sbjct: 417 AF--RLRSYAQKIGGRQQLAIEKFADAIEEIPRALAENAGLDPIDILLKLRAEH------ 468 Query: 489 AVKTDHLYKGVDI-DGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQII 545 K + Y G+++ GE ++D+ + + + + K AI ATEAA +L ID +I Sbjct: 469 -AKGNKTY-GINVFTGE----IEDMVKNGVIEPIRVGKQAIESATEAAIMILRIDDVI 520 >3IYF-A nrPDB Length = 521 Score = 214 bits (546), Expect = 7e-56, Method: Compositional matrix adjust. Identities = 161/552 (29%), Positives = 288/552 (52%), Gaps = 53/552 (9%) Query: 5 LPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIII 64 + Q P G+ + Y D Q + +I A R + + +++GP G +K++V+ LG +++ Sbjct: 1 MSQQP--GVLPENMKRYMGRDAQRM-NILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVV 57 Query: 65 TNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSA 124 TND T+LRE+ + HPA K+L+ + Q+ ++GDGT +++AGELL +E+L+ + Sbjct: 58 TNDGVTILREMSVEHPAAKMLIEVAKTQEKEVGDGTTTAVVVAGELLRKAEELLDQNVHP 117 Query: 125 VEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSK-KYGSEDILSELVS 183 +++GY A + +EL + + E+ DK L K+ I+ K +++ L+E++ Sbjct: 118 TIVVKGYQAAAQKA-QELLKTIACEVG-AQDKEILTKIAMTSITGKGAEKAKEKLAEIIV 175 Query: 184 EAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDK 243 EAVS V+ G++ + D I++ K G S+ ++ +IKG++ ++E V + K Sbjct: 176 EAVSAVV---DDEGKV---DKDLIKIEKKSGASIDDTELIKGVLVDKE---RVSAQMPKK 226 Query: 244 --KHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVA 301 K+A+ C ++ A EML M+ EI G + Sbjct: 227 VTDAKIALLNCAIE------------ETASEML----------KDMVAEIKASGANVLFC 264 Query: 302 GAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTM 361 G+ +LA HYL + GI+ + K ++ +L + GA + + + ++LG V+ Sbjct: 265 QKGIDDLAQHYLAKEGIVAARRVKKSDMEKLAKATGANVITNIKDLSAQDLGDAGLVEER 324 Query: 362 EIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLP 421 +I GD + E+ + + T+++RG T++ ++++ RA+DD V V ++ G+++ Sbjct: 325 KISGDSMIFV--EECKHPKAVTMLIRGTTEHVIEEVARAVDDAVGVVGCTIED--GRIVS 380 Query: 422 GAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAA 481 G G+TE+EL ++ +Y E G QLA++ FA A EV+PRTLAE AGLD E+L + AA Sbjct: 381 GGGSTEVELSMKLREYAEGISGREQLAVRAFADALEVIPRTLAENAGLDAIEILVKVRAA 440 Query: 482 HNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSI 541 H + +++ G V+D+ E + + L K AI A E+ +L I Sbjct: 441 H-ASNGNKCAGLNVFTG---------AVEDMCENGVVEPLRVKTQAIQSAAESTEMLLRI 490 Query: 542 DQIIMAKKAGGP 553 D +I A+K G Sbjct: 491 DDVIAAEKLRGA 502 >5GW4-h nrPDB Length = 550 Score = 197 bits (501), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 156/567 (27%), Positives = 274/567 (48%), Gaps = 38/567 (6%) Query: 7 QNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITN 66 Q P + K+G ++ S GQII +I A + + ++GP G + +IV K I+N Sbjct: 6 QTPTIVVLKEGTDA-SQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISN 64 Query: 67 DAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVE 126 D AT+L+ LD+VHPA K LV + Q ++GDGT V ILAGEL+ ++ + G+S+ Sbjct: 65 DGATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHL 124 Query: 127 IIQGYNMARKFTLKELDEMVVGEITDKNDKNELL-KMIKPVISSKK-YGSEDILSELVSE 184 I++GY A +++++E+ V ++K+ ELL + + +SSK + + D ++ + Sbjct: 125 IMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVD 184 Query: 185 AVSHVLPVAQQAGEIPYFNVDS--IRVVKIMGGSLSNSTVIKGMVFNR--EPEGHVKSLS 240 AV + ++D I + KI GG++ S I G+ F + G + Sbjct: 185 AVLS----------LDRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPK 234 Query: 241 EDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIV 300 + K+ L++ + V + + ++ E + I ++++ + G ++ Sbjct: 235 KFNNPKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVL 294 Query: 301 AGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKT 360 + +G+LA + I S ++ R+ + G + PE LG + Sbjct: 295 SKLPIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEE 354 Query: 361 MEIGGDRVTVFKQEQG-EISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKL 419 M+IG +R +F QG ++T T++LRG + + ++ER++ D + VK ++ + Sbjct: 355 MQIGSERYNLF---QGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNK--LI 409 Query: 420 LPGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLY 479 + G GATE+E+ + Y + G Q+ I FA A EV+PR L E AG D E+L L Sbjct: 410 VAGGGATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLR 469 Query: 480 AAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVL 539 AH+ E + GV + E+ + D + +++ K A+N ATEA +L Sbjct: 470 LAHSKGEK--------WYGVVFETEN---IGDNFAKFVWEPALVKINALNSATEATNLIL 518 Query: 540 SIDQIIMAKKAGGPRA----PQGPRPG 562 S+D+ I K + A PQG G Sbjct: 519 SVDETITNKGSESANAGMMPPQGAGRG 545 >5UYZ-A nrPDB Length = 541 Score = 196 bits (498), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 135/513 (26%), Positives = 265/513 (51%), Gaps = 17/513 (3%) Query: 32 IAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVHPAVKVLVMATEQ 91 I A + + TS+GP G +K++V+ G + +TND AT+L +D+ H K++V ++ Sbjct: 38 IMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKS 97 Query: 92 QKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNMARKFTLKELDEMVVGEIT 151 Q ++GDGT V++LAG LL +E+L+ G+ + I GY A + ++ LD++ + Sbjct: 98 QDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIERLDKISDSVLV 157 Query: 152 DKNDKNELLKMIKPVISSKKYGSEDILSELVSEAVSHVLPVAQQAGEIPYFNVDSIRVVK 211 D D L++ K + SK S ++ AV+ VL VA E + + I+V Sbjct: 158 DIKDTEPLIQTAKTTLGSKVVNS--CHRQMAEIAVNAVLTVADM--ERRDVDFELIKVEG 213 Query: 212 IMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFTCPLDIANTETKGTVLLHNAQ 271 +GG L ++ +IKG++ +++ H + + + K+A+ TCP + +TK + + + + Sbjct: 214 KVGGRLEDTKLIKGVIVDKDF-SHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVE 272 Query: 272 EMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGELALHYLNRYGILVLKVPSKFELRR 331 + K E+++ + M+++I + G + G + A H L + + ++ E+ Sbjct: 273 DYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIEL 332 Query: 332 LCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGDRVTVFKQEQGEISRTSTIILRGATQ 391 + G +PR T E+LG V+ + G + + EQ + SR TI +RG + Sbjct: 333 IAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNK 392 Query: 392 NNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATEIELISRITKYGERTPGLLQLAIKQ 451 +++ +R++ D + ++ L++ + +++ G GA EI +++ ++ P L Q A++ Sbjct: 393 MIIEEAKRSLHDALCVIRNLIRDN--RVVYGGGAAEISCALAVSQEADKCPTLEQYAMRA 450 Query: 452 FAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPGAVKTDHLYKGVDIDGESDEGVKD 511 FA A EV+P L+E +G++ + + + A A+ D L+KG + D Sbjct: 451 FADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTN----------D 500 Query: 512 IREENIYDMLATKKFAINVATEAATTVLSIDQI 544 ++++++ + L KK I++AT+ +L ID I Sbjct: 501 MKQQHVIETLIGKKQQISLATQMVRMILKIDDI 533 >4B2T-H nrPDB Length = 543 Score = 195 bits (495), Expect = 5e-50, Method: Compositional matrix adjust. Identities = 148/541 (27%), Positives = 267/541 (49%), Gaps = 36/541 (6%) Query: 13 LFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATML 72 L K+G +S S Q++ +I+A + + + T++GP G +K+IV+ GK I+ND AT+L Sbjct: 8 LLKEGTDS-SQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATIL 66 Query: 73 RELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYN 132 + LD+VHPA K LV + Q ++GDGT V +LA E L + + GL II+ + Sbjct: 67 KLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFR 126 Query: 133 MARKFTLKELDEMVVGEITDKNDKNELLKMIKPV----ISSKKYGSED-ILSELVSEAVS 187 A + + ++ E+ V K DK E K+++ +SSK + +++V +AV Sbjct: 127 TATQLAVNKIKEIAV--TVKKEDKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDAVM 184 Query: 188 HVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHK- 246 + + Q + I + K+ GG+L S ++ G+ F + + K H Sbjct: 185 MLDDLLQ---------LKMIGIKKVQGGALEESQLVAGVAFKKTFSYAGFEMQPKKYHNP 235 Query: 247 -VAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGV 305 +A+ L++ + + +H ++ E + +++I G + +++ + Sbjct: 236 MIALLNVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPI 295 Query: 306 GELALHYL-NRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIG 364 G++A Y +R +VP + +L+R CG + + A + + LG + + +IG Sbjct: 296 GDVATQYFADRDMFCAGRVPEE-DLKRTMMACGGSIQTSVNALSSDVLGRCQVFEETQIG 354 Query: 365 GDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAG 424 G+R F ++T TIILRG + +++ ER++ D + V+ +K ++ G G Sbjct: 355 GERYNFFT--GCPKAKTCTIILRGGAEQFMEETERSLHDAIMIVRRAIK--NDSVVAGGG 410 Query: 425 ATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNV 484 A E+EL + Y PG QL I +A A E++PR L + AG D +L L A H Sbjct: 411 AIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARH-- 468 Query: 485 TEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQI 544 + G ++ GVDI+ E + D E +++ + A+ A+EAA ++S+D+ Sbjct: 469 AQGG------MWYGVDINTED---IADNFEAFVWEPAMVRINALTAASEAACLIVSVDET 519 Query: 545 I 545 I Sbjct: 520 I 520 >4B2T-D nrPDB Length = 542 Score = 190 bits (483), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 149/543 (27%), Positives = 275/543 (50%), Gaps = 38/543 (6%) Query: 16 QGYNSYSNAD--GQI-IKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATML 72 +G ++Y + D QI +I+A + + TS+GP G +K+I + G + ITND AT+L Sbjct: 22 RGKSAYQDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATIL 81 Query: 73 RELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYN 132 +++ ++HPA ++LV ++ Q I+ GDGT V+I+AG LL+ KL+ G+ I + + Sbjct: 82 KQMQVLHPAARMLVELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQ 141 Query: 133 MARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSK---KYGSEDILSELVSEAVSHV 189 A + ++ L +M + +D+ LL ++SK +Y S +LS + +AV V Sbjct: 142 KALEKGIEILTDM--SRPVELSDRETLLNSAATSLNSKVVSQYSS--LLSPMSVDAVMKV 197 Query: 190 LPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAV 249 + A ++ I++VK +GG++ + +++G+V ++ ++ +K K+ + Sbjct: 198 IDPATATS----VDLRDIKIVKKLGGTIDDCELVEGLVLTQKVANS--GITRVEKAKIGL 251 Query: 250 FTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGV---- 305 L T+ +++ + +M + E I ++K+I G ++ + Sbjct: 252 IQFCLSAPKTDMDNQIVVSDYVQMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDA 311 Query: 306 -GELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIG 364 +LALH+LN+ I+V+K + ++ +C+ G P+ + T + LG E + + + Sbjct: 312 LSDLALHFLNKMKIMVVKDIEREDIEFICKTIGTKPVAHVDQFTADMLGSAELAEEVSLN 371 Query: 365 GDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAG 424 G + +T TI++RG+ + +++ ER+I D + ++ L+K L+ G G Sbjct: 372 GSGKLIKITGCASPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRA--LIAGGG 429 Query: 425 ATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNV 484 A EIEL R+T+Y G+ I+ FA A EV+P TLAE AGL+ + L H Sbjct: 430 APEIELALRLTEYSRTLSGMESYCIRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQ 489 Query: 485 TEPGAVKTD--HLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSID 542 E KT ++ KG G+ +I EE + L A+ +ATE ++L ID Sbjct: 490 GE----KTTGINVRKG---------GISNILEELVVQPLLVSVSALTLATETVRSILKID 536 Query: 543 QII 545 ++ Sbjct: 537 DVV 539 >4B2T-A nrPDB Length = 556 Score = 189 bits (479), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 160/537 (29%), Positives = 270/537 (50%), Gaps = 36/537 (6%) Query: 26 GQIIKS--IAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVHPAVK 83 G+ I+S + A + + +S+GP G +K++V+ +G + ITND AT+L+ L++ HPA K Sbjct: 14 GEAIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLLEVEHPAAK 73 Query: 84 VLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNMARKFTLKELD 143 VL + Q ++GDGT V+I+A ELL +++L+ + +I GY +A K ++ + Sbjct: 74 VLCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLACKEAVRYIS 133 Query: 144 EMVVGEITDKNDKNELLKMIKPVISSKKYG-SEDILSELVSEAVSHVLPVAQQAGEI--- 199 E ++ TD+ ++ L+ K +SSK G + D + LV +AV +A + +I Sbjct: 134 ENLIIN-TDELGRDCLINAAKTSMSSKVIGINGDFFANLVVDAV-----LAIKYTDIRGQ 187 Query: 200 PYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFTCPLDIANT 259 P + V+SI V+K G S S +I G N V S K+ A C LD + Sbjct: 188 PRYPVNSINVLKAHGRSQMESMLINGYALN----CVVGSQGMPKRIVNAKIAC-LDFSLQ 242 Query: 260 ETK---GTVLLHNAQEMLDFSKGEEKQIDA-MMKEIADMGVECIVAGAGVGELALHYLNR 315 +TK G ++ E LD + E I +++I G I+ G+ ++ L Y Sbjct: 243 KTKMKLGVQVVITDPEKLDQIRQRESDITKERIQKILATGANVILTTGGIDDMCLKYFVE 302 Query: 316 YGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEE------LGLVETVKTMEIGGDRVT 369 G + ++ K +L+R+ + GAT L L EE LG E V I D + Sbjct: 303 AGAMAVRRVLKRDLKRIAKASGATVLSTLANLEGEETFEASMLGQAEEVVQERICDDELI 362 Query: 370 VFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATEIE 429 + K + S +++ILRGA D++ER++ D + VK +++ ++PG GA E Sbjct: 363 LIKNTKARTS--ASVILRGANDFMCDEMERSLHDALCVVKRVLESKS--VVPGGGAVEAA 418 Query: 430 LISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPGA 489 L + Y QLAI +FA + V+P TLA A D +++ L A HN + Sbjct: 419 LSIYLENYATSMGSREQLAIAEFARSLPVIPNTLAVNAAQDSTDLVAKLRAFHNEAQVNP 478 Query: 490 VKTDHLYKGVD-IDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQII 545 + + + G+D ++G+ +D ++ +++ K ++ ATEAA T+L ID +I Sbjct: 479 ERKNLKWIGLDLVNGKP----RDNKQAGVFEPTIVKVKSLKFATEAAITILRIDDLI 531 >5GW5-g nrPDB Length = 534 Score = 186 bits (472), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 152/526 (28%), Positives = 267/526 (50%), Gaps = 29/526 (5%) Query: 29 IKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVHPAVKVLVMA 88 I +I A + + + T +GP K++++ +G +++TND +LRE+D+ HPA K ++ Sbjct: 22 ISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVAHPAAKSMLEL 81 Query: 89 TEQQKIDMGDGTNLVMILAGELL-NVSEKLISMGLSAVEIIQGYNMARKFTLKELDEMVV 147 + Q ++GDGT V+ILAGE+L + LI + V IIQ A L+ + + V Sbjct: 82 SRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDALEVIKQ--V 139 Query: 148 GEITDKNDKNELLKMIKPVISSKK--YGSEDILSELVSEAVSHVLP-VAQQAGEIPYFNV 204 + D + + K+I+ I +K + SE + EL +AV V + Q P F + Sbjct: 140 SKPVDVENDAAMKKLIQASIGTKYVIHWSEK-MCELALDAVKTVRKDLGQTVEGEPNFEI 198 Query: 205 D---SIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFTCPLDIANTET 261 D +RV KI GG + +S V+KG++ N++ H K + +V + CPL+ E+ Sbjct: 199 DIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVV-HPKMSRHIENPRVVLLDCPLEYKKGES 257 Query: 262 KGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGELALHYLNRYGILVL 321 + + + ++ + EE+Q+ M ++I + ++ GV +LA HYL + G VL Sbjct: 258 QTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSDLAQHYLLKGGCSVL 317 Query: 322 KVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGDRVTVFKQEQGEISRT 381 + K + R+ RV GAT + R+ ++G + +E+ GD F E + Sbjct: 318 RRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDEYFSFLDNCKE-PKA 376 Query: 382 STIILRGATQNNLDDIERAIDDGVAAVKGLM-KPSGGKLLPGAGATEIELISRITKYGER 440 TI+LRG +++ L++I+R + D +A + +M PS L PG GATE+ + ++ + ++ Sbjct: 377 CTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPS---LSPGGGATEMAVSVKLAEKAKQ 433 Query: 441 TPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPGAVKTDHLYKGVD 500 G+ Q + A A E +PRTL + AG D +L L A H + G+D Sbjct: 434 LEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKH--------AQGNFTTGID 485 Query: 501 IDGESDEG-VKDIREENIYDMLATKKFAINVATEAATTVLSIDQII 545 D+G + D+ I++ K+ ++ A E+A +L +D I+ Sbjct: 486 ----GDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIV 527 >4V8R-AE nrPDB Length = 562 Score = 186 bits (472), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 143/527 (27%), Positives = 270/527 (51%), Gaps = 27/527 (5%) Query: 32 IAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVHPAVKVLVMATEQ 91 I A R + + TS+GP G +KI+++ G+I ITND AT+L ++++ + K+LV ++ Sbjct: 51 ILAARSVASIIKTSLGPRGLDKILISPDGEITITNDGATILSQMELDNEIAKLLVQLSKS 110 Query: 92 QKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNMARKFTLKELDEMVVGEIT 151 Q ++GDGT V++LA LL+ + +LI G+ ++I G++ A K + +L+E +I+ Sbjct: 111 QDDEIGDGTTGVVVLASALLDQALELIQKGIHPIKIANGFDEAAKLAISKLEE-TCDDIS 169 Query: 152 DKND---KNELLKMIKPVISSKKYGSE-DILSELVSEAVSHVLPVAQQAGEIPYFNVDSI 207 ND ++ LL+ K + SK + D +E+ EAV +V+ ++ + D I Sbjct: 170 ASNDELFRDFLLRAAKTSLGSKIVSKDHDRFAEMAVEAVINVMDKDRKD-----VDFDLI 224 Query: 208 RVVKIMGGSLSNSTVIKGMVFNRE---PEGHVKSLSEDKKH--KVAVFTCPLDIANTETK 262 ++ +GGS+S+S +I G++ +++ P+ L ++ K+A+ TCP + +TK Sbjct: 225 KMQGRVGGSISDSKLINGVILDKDFSHPQMPKCVLPKEGSDGVKLAILTCPFEPPKPKTK 284 Query: 263 GTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGELALHYLNRYGILVLK 322 + + + +E E+ + M+ ++ G + ++ G + A H L + + ++ Sbjct: 285 HKLDISSVEEYQKLQTYEQDKFKEMIDDVKKAGADVVICQWGFDDEANHLLLQNDLPAVR 344 Query: 323 VPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGDRVTVFKQEQGEISRTS 382 EL + +PR + ++LG + E G + + EQ + ++T Sbjct: 345 WVGGQELEHIAISTNGRIVPRFQDLSKDKLGTCSRIYEQEFGTTKDRMLIIEQSKETKTV 404 Query: 383 TIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATEIELISRITKYGERTP 442 T +RG+ + +D+ ERA+ D + V+ L+K S +++ G GA E+ + +++ ++ Sbjct: 405 TCFVRGSNKMIVDEAERALHDSLCVVRNLVKDS--RVVYGGGAAEVTMSLAVSEEADKQR 462 Query: 443 GLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPGAVKTDHLYKGVDID 502 G+ Q A + FA A + +P TLAE +GLD L L + +K GVD Sbjct: 463 GIDQYAFRGFAQALDTIPMTLAENSGLDPIGTLSTLKSKQ-------LKEKISNIGVDCL 515 Query: 503 GESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQIIMAKK 549 G G D++E + D KK I +AT+ +L ID +I++ K Sbjct: 516 G---YGSNDMKELFVVDPFIGKKQQILLATQLCRMILKIDNVIISGK 559 >4B2T-G nrPDB Length = 545 Score = 184 bits (468), Expect = 7e-47, Method: Compositional matrix adjust. Identities = 150/547 (27%), Positives = 267/547 (48%), Gaps = 48/547 (8%) Query: 31 SIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVHPAVKVLVMATE 90 +I A + + + T +GP K++++ +G I++TND +LRE+ + HPA K ++ + Sbjct: 26 NINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISR 85 Query: 91 QQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNMARKFTLKELDEMVVGEI 150 Q ++GDGT V+ILAGE+L+V+E + + +I Y A + L ++ + Sbjct: 86 TQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRKALDDMISTLKKISIP-- 143 Query: 151 TDKNDKNELLKMIKPVISSKKYGSEDILSELVSEAVSHVLPVAQ--QAGEIPYFNVD--- 205 D ++++ +L +I I++K ++S S A + L + Q E +D Sbjct: 144 VDTSNRDTMLNIINSSITTK------VISRWSSLACNIALDAVKTVQFEENGRKEIDIKK 197 Query: 206 SIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFTCPLDIANTETKGTV 265 RV KI GG + +S V++G++ N++ H + K ++ + L+ E++ + Sbjct: 198 YARVEKIPGGIIEDSCVLRGVMINKDVT-HPRMRRYIKNPRIVLLDSSLEYKKGESQTDI 256 Query: 266 LLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGELALHYLNRYGILVLKVPS 325 + ++ + EE+ I + ++I + + ++ G+ +LA HYL R I ++ Sbjct: 257 EITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQHYLMRANITAIRRVR 316 Query: 326 KFELRRLCRVCGATPLPRLGAPTPEEL---------GLVETVKTMEIGGDRVTVFKQEQG 376 K + R+ R CGA + R PEEL GL+E K GD F E Sbjct: 317 KTDNNRIARACGARIVSR-----PEELREEDVGTGAGLLEIKKI----GDEYFTFITECK 367 Query: 377 EISRTSTIILRGATQNNLDDIERAIDDGVAAVKG-LMKPSGGKLLPGAGATEIELISRIT 435 + + TI+LRGA++ L ++ER + D + + L+ P +L+PG GA+E+ + +T Sbjct: 368 D-PKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDP---QLVPGGGASEMAVAHALT 423 Query: 436 KYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPGAVKTDHL 495 + + G+ Q + A A EV+PRTL + G +L +L A H T Sbjct: 424 EKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKH---------TQEN 474 Query: 496 YKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQIIMA-KKAGGPR 554 + ++GE+ V D++E I++ LA K A E A +L ID I+ KK G + Sbjct: 475 CETWGVNGETGTLV-DMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQ 533 Query: 555 APQGPRP 561 + QG P Sbjct: 534 SRQGGAP 540 >5GW4-d nrPDB Length = 528 Score = 184 bits (466), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 149/557 (26%), Positives = 274/557 (49%), Gaps = 38/557 (6%) Query: 1 MSLRLPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLG 60 MS ++P N FK II A R + TS+GP G +K+I G Sbjct: 1 MSAKVPSNAT---FKNKEKPQEVRKANII----AARSVADAIRTSLGPKGMDKMIKTSRG 53 Query: 61 KIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISM 120 +III+ND T+L+++ I+HP ++LV + Q + GDGT V+IL G LL +E+L++ Sbjct: 54 EIIISNDGHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNK 113 Query: 121 GLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSK---KYGSEDI 177 G+ I + A K ++ L EM +D+ +L++ +SSK +Y S Sbjct: 114 GIHPTIIADSFQSAAKRSVDILLEMC--HKVSLSDREQLVRAASTSLSSKIVSQYSS--F 169 Query: 178 LSELVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVK 237 L+ L AV VL ++ + + +++ IR+VK +GG++ ++ +I G+V + Sbjct: 170 LAPL---AVDSVLKISDENSK--NVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAG 224 Query: 238 SLSEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQI-----DAMMKEIA 292 + +K K+ + + +T+ +++++ ++M K E + + Sbjct: 225 GPTRKEKAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCN 284 Query: 293 DMGVECIVAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEEL 352 + ++ + V +LALH+L++ I+V+K + E+ L + G P+ + T + L Sbjct: 285 VLLIQKSILRDAVNDLALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRL 344 Query: 353 GLVETVKTMEIGGDRVTVFKQEQGEISR-TSTIILRGATQNNLDDIERAIDDGVAAVKGL 411 G + V+ ++ G ++ + +R T ++++RGA +D+ ER++ D + ++ L Sbjct: 345 GSADLVEEIDSDGSKIVRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCL 404 Query: 412 MKPSGGKLLPGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDV 471 +K G L+ G GA EIE+ R++K G+ ++FA A EV+P TLAE AGL+ Sbjct: 405 VKERG--LIAGGGAPEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNS 462 Query: 472 NEVLPNLYAAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVA 531 +V+ L + H E L G+ + G + EE+I + AI +A Sbjct: 463 IKVVTELRSKHENGE--------LNDGISV---RRSGTTNTYEEHILQPVLVSTSAITLA 511 Query: 532 TEAATTVLSIDQIIMAK 548 +E ++L ID I ++ Sbjct: 512 SECVKSILRIDDIAFSR 528 >4V94-A nrPDB Length = 559 Score = 177 bits (449), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 151/517 (29%), Positives = 255/517 (49%), Gaps = 28/517 (5%) Query: 44 TSMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLV 103 +S+GP G +K++V+ +G +TND AT+L LD+ HPA K+LV +QQ ++GDGT V Sbjct: 42 SSLGPVGLDKMLVDDIGDFTVTNDGATILSLLDVQHPAGKILVELAQQQDREIGDGTTSV 101 Query: 104 MILAGELLNVSEKLISMGLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMI 163 +I+A ELL + +L+ + II G+ +A + ++ ++E V+ D K L+ + Sbjct: 102 VIIASELLKRANELVKNKIHPTTIITGFRVALREAIRFINE-VLSTSVDTLGKETLINIA 160 Query: 164 KPVISSKKYGSE-DILSELVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTV 222 K +SSK G++ D S +V +A+ V GEI Y V ++ V+K G S + S + Sbjct: 161 KTSMSSKIIGADSDFFSNMVVDALLAV-KTQNSKGEIKY-PVKAVNVLKAHGKSATESLL 218 Query: 223 IKGMVFNREPEGHVKSLSEDKK-----HKVAVFTCPLDIANTETKGTVLLHNAQEMLDFS 277 + G N V S + K+ K+A L A + + + +++ Sbjct: 219 VPGYALN----CTVASQAMPKRIAGGNVKIACLDLNLQKARMAMGVQINIDDPEQLEQIR 274 Query: 278 KGEEKQIDAMMKEIADMGVECIVAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCG 337 K E + +K+I D G + ++ G+ +L L I+ ++ K +LRR+ R G Sbjct: 275 KREAGIVLERVKKIIDAGAQVVLTTKGIDDLCLKEFVEAKIMGVRRCKKEDLRRIARATG 334 Query: 338 ATPLPRLGAPTPEE------LGLVETVKTMEIGGDRVTVFKQEQGEISRTSTIILRGATQ 391 AT + + EE LGL + V + D + K S S+IILRGA Sbjct: 335 ATLVSSMSNLEGEETFESSYLGLCDEVVQAKFSDDECILIKGTSKHSS--SSIILRGAND 392 Query: 392 NNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATEIELISRITKYGERTPGLLQLAIKQ 451 +LD++ER++ D ++ VK ++ G ++PG G E L + + QLAI + Sbjct: 393 YSLDEMERSLHDSLSVVKRTLE--SGNVVPGGGCVEAALNIYLDNFATTVGSREQLAIAE 450 Query: 452 FAVAFEVVPRTLAETAGLDVNEVLPNL---YAAHNVTEPGAVKTDHLYKGVDIDGESDEG 508 FA A ++P+TLA A D +E++ L +AA + +P VK Y+ +D + Sbjct: 451 FAAALLIIPKTLAVNAAKDSSELVAKLRSYHAASQMAKPEDVKR-RSYRNYGLDLIRGKI 509 Query: 509 VKDIREENIYDMLATKKFAINVATEAATTVLSIDQII 545 V +I + + +K ++ A EA +L ID +I Sbjct: 510 VDEI-HAGVLEPTISKVKSLKSALEACVAILRIDTMI 545 >4B2T-Z nrPDB Length = 531 Score = 174 bits (442), Expect = 8e-44, Method: Compositional matrix adjust. Identities = 152/544 (27%), Positives = 269/544 (49%), Gaps = 51/544 (9%) Query: 22 SNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVHPA 81 + A + +I+A R L + T++GP G K++V+ G I +T D +L E+ I HP Sbjct: 14 ARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQIQHPT 73 Query: 82 VKVLV-MATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNMARKFTLK 140 ++ +AT Q I GDGT +++ GELL ++ IS GL I +G+ A++ L+ Sbjct: 74 ASLIAKVATAQDDI-TGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQ 132 Query: 141 ELDEMVVGEITDKNDKNELLKMIKPVISSKKYGS-EDILSELVSEAVSHVLPVAQQAGEI 199 L+++ +++ + D+ L+ + + + +K + D+L+E V V +L + +Q I Sbjct: 133 FLEQV---KVSKEMDRETLIDVARTSLRTKVHAELADVLTEAV---VDSILAIKKQDEPI 186 Query: 200 PYFNVDSIRVVKIMGGSLSNSTVIKGMVFN---REPEGHVKSLSEDKKHKVAVFTC--PL 254 F V+ ++++ S +++++I+G+V + R P+ +K ED + TC L Sbjct: 187 DLFMVE---IMEMKHKSETDTSLIRGLVLDHGARHPD--MKKRVED----AYILTCNVSL 237 Query: 255 DIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEI----------ADMGVECIVAGAG 304 + TE +A+E K E K I+ +K+I +D G ++ G Sbjct: 238 EYEKTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIIELKKKVCGDSDKGF-VVINQKG 296 Query: 305 VGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIG 364 + +L L + GI+ L+ + + RL CG L L P+ LG V +G Sbjct: 297 IDPFSLDALAKEGIIALRRAKRRNMERLTLACGGIALNSLDDLNPDCLGHAGLVYEYTLG 356 Query: 365 GDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAG 424 ++ T E+ R+ T++++G ++ L I+ AI DG+ AVK + G ++PGAG Sbjct: 357 EEKFTFI--EKCNNPRSVTLLIKGPNKHTLTQIKDAIRDGLRAVKNAI--DDGCVVPGAG 412 Query: 425 ATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNV 484 A E+ + + KY G QL ++ FA A ++P+ LA+ +G D+ E L + A H Sbjct: 413 AVEVAMAEALVKYKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKVQAEH-- 470 Query: 485 TEPGAVKTDHLYKGVDID-GESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQ 543 +E G + GVD++ GE E I+D KK ++ T AT +L +D+ Sbjct: 471 SESGQL------VGVDLNTGEPMVAA----EAGIWDNYCVKKQLLHSCTVIATNILLVDE 520 Query: 544 IIMA 547 I+ A Sbjct: 521 IMRA 524 >5GW5-z nrPDB Length = 546 Score = 152 bits (383), Expect = 5e-37, Method: Compositional matrix adjust. Identities = 151/577 (26%), Positives = 267/577 (46%), Gaps = 51/577 (8%) Query: 1 MSLRLPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLG 60 MSL+L NP A ++ D + ++ + L + T++GP G K++V+ G Sbjct: 1 MSLQL-LNPKAESLRR--------DAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAG 51 Query: 61 KIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISM 120 I +T D +L E+ I P ++ A Q GDGT V+ L GELL + + I Sbjct: 52 NIKLTKDGKVLLTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQE 111 Query: 121 GLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGS-EDILS 179 G+ I G+ +ARK ++K LDE + + ND+ LL++ + + +K ++L+ Sbjct: 112 GVHPRIITDGFEIARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLT 171 Query: 180 ELVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFN---REPEGHV 236 +V++AV V QA + ++ + ++++ S ++T IKG+V + R P+ Sbjct: 172 PIVTDAVLSVYDA--QADNL---DLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDMPT 226 Query: 237 KSLSEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGV 296 + K V + L+ TE +A + + E K +DA +K+I D+ Sbjct: 227 RV----KNAYVLILNVSLEYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKN 282 Query: 297 E-C---------IVAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGA 346 E C I+ G+ ++L ++ IL L+ + + RL V G + Sbjct: 283 EVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVED 342 Query: 347 PTPEELGLVETVKTMEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVA 406 +P+ LG V IG ++ T + ++ TI+++G+T L + A+ DG+ Sbjct: 343 LSPQILGFSGLVYQETIGEEKFTYVTENTD--PKSCTILIKGSTHYALAQTKDAVRDGLR 400 Query: 407 AVKGLMKPSGGKLLPGAGATEIEL-----ISRITKYGERTPGLLQLAIKQFAVAFEVVPR 461 AV ++K ++PGAGA I L + + K G + G + I+ FA A V+P+ Sbjct: 401 AVANVLKDKN--IIPGAGAFYIALSRYLRSANMNKLGAK--GKTKTGIEAFAEALLVIPK 456 Query: 462 TLAETAGLDVNEVLPNLYAAHNVTEPGAVKTDHLYKGVDID-GESDEGVKDIREENIYDM 520 TL + +G D +VL + + + Y GVD++ G+S D E I+D Sbjct: 457 TLVKNSGFDPLDVLA---MVEDELDDAQDSDETRYVGVDLNIGDS----CDPTIEGIWDS 509 Query: 521 LATKKFAINVATEAATTVLSIDQIIMAKKAGGPRAPQ 557 + AI AT A+ +L D+++ A ++ PQ Sbjct: 510 YRVLRNAITGATGIASNLLLCDELLRAGRSTLKETPQ 546 >4B2T-B nrPDB Length = 535 Score = 146 bits (369), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 141/557 (25%), Positives = 266/557 (47%), Gaps = 50/557 (8%) Query: 13 LFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVN--HLGKIIITNDAAT 70 +FK G + ++ I AI + + +++GP G +KI+++ +++TND AT Sbjct: 11 IFKAGADEERAETARLSSFIGAI-AIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGAT 69 Query: 71 MLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQG 130 +L+ + + +PA KVLV + Q ++GDGT V +LA ELL +E LI+ + II G Sbjct: 70 ILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIAG 129 Query: 131 YNMARKFTLKELDEMVVGEITDK-NDKNELLKMIKPVISSKKYG-SEDILSELVSEAVSH 188 + A K + L V +D+ + +L+ + +SSK +D ++L EAV Sbjct: 130 WREATKAARQALLNSAVDHGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLR 189 Query: 189 VLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVA 248 + + +G N+++I V+K +GGSL++S + +G + +++ V + K+ Sbjct: 190 L----KGSG-----NLEAIHVIKKLGGSLADSYLDEGFLLDKKIG--VNQPKRIENAKIL 238 Query: 249 VFTCPLDIANTETKGT-VLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGE 307 + +D + G+ V + + ++ + E++++ ++ I G+ C + + Sbjct: 239 IANTGMDTDKIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYN 298 Query: 308 LALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGDR 367 G++ ++ + RL V G P +LG + ++ + IG D+ Sbjct: 299 YPEQLFGAAGVMAIEHADFVGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVMIGEDK 358 Query: 368 VTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATE 427 + F + TI+LRGATQ LD+ ER++ D + + +K S + + G G +E Sbjct: 359 LIHFSGVA--LGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDS--RTVYGGGCSE 414 Query: 428 IELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEP 487 + + +T+ RTPG +A++ +A A ++P +A+ AG D +++ L AAH+ Sbjct: 415 MLMAHAVTQLASRTPGKEAVAMESYAKALRMLPTIIADNAGYDSADLVAQLRAAHS---- 470 Query: 488 GAVKTDHLYKGVDIDGESDEGVKDIREENIYDM--------LATKKFAINVATEAATTVL 539 +G++ G+ D++E I DM K+ + A EAA +L Sbjct: 471 --------------EGKTTAGL-DMKEGTIGDMSVLGITESFQVKRQVLLSAAEAAEVIL 515 Query: 540 SIDQIIMAKKAGGPRAP 556 +D II K A R P Sbjct: 516 RVDNII--KAAPRKRVP 530 >4V8R-AB nrPDB Length = 527 Score = 139 bits (350), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 131/514 (25%), Positives = 248/514 (48%), Gaps = 39/514 (7%) Query: 44 TSMGPCGRNKIIVN-HLGKIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNL 102 +++GP G +K++ + ++TND AT+L+ + + +PA KVLV ++ Q ++GDGT Sbjct: 35 STLGPKGMDKLLQSASSNTCMVTNDGATILKSIPLDNPAAKVLVNISKVQDDEVGDGTTS 94 Query: 103 VMILAGELLNVSEKLISMG-LSAVEIIQGYNMARKFTLKELDEMVVGEITDKN-DKNELL 160 V +L+ ELL +EKLI + II+GY +A L L + V DK + +L+ Sbjct: 95 VTVLSAELLREAEKLIDQSKIHPQTIIEGYRLASAAALDALTKAAVDNSHDKTMFREDLI 154 Query: 161 KMIKPVISSKKYGSE-DILSELVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSN 219 + K +SSK + D +EL + A+ + N++ I+++KI+GG LS+ Sbjct: 155 HIAKTTLSSKILSQDKDHFAELATNAILRLKGST---------NLEHIQIIKILGGKLSD 205 Query: 220 STVIKGMVFNREPEGHVKSLSEDKKHKVAVFTCPLDIANTETKGTVL-LHNAQEMLDFSK 278 S + +G + ++ + E+ K+ + LD + GT + + ++ K Sbjct: 206 SFLDEGFILAKKFGNNQPKRIENA--KILIANTTLDTDKVKIFGTKFKVDSTAKLAQLEK 263 Query: 279 GEEKQIDAMMKEIADMGVECIVAGAGVGELALHYLNRYGILVLKVPSKFE-LRRLCRVCG 337 E +++ + +I+ G+ + + + GI ++ + FE + RL V G Sbjct: 264 AEREKMKNKIAKISKFGINTFINRQLIYDYPEQLFTDLGINSIE-HADFEGVERLALVTG 322 Query: 338 ATPLPRLGAPTPEELGLVETVKTMEIGGDRVTVFKQ-EQGEISRTSTIILRGATQNNLDD 396 + P+ +LG + ++ + +G F + GE TI+LRGAT LD+ Sbjct: 323 GEVVSTFDEPSKCKLGECDVIEEIMLGEQPFLKFSGCKAGE---ACTIVLRGATDQTLDE 379 Query: 397 IERAIDDGVAAVKGLMKPSGGKLLPGAGATEIELISRITKYGERTPGLLQLAIKQFAVAF 456 ER++ D ++ + K + + + G G E+ + + + G LA++ FA A Sbjct: 380 AERSLHDALSVLSQTTKET--RTVLGGGCAEMVMSKAVDTEAQNIDGKKSLAVEAFARAL 437 Query: 457 EVVPRTLAETAGLDVNEVLPNLYAAHNVTEPGAVKTDHLYKGVDIDG-ESDEG-VKDIRE 514 +P LA+ AG D +E++ L ++ +Y G+ G + + G + D+R+ Sbjct: 438 RQLPTILADNAGFDSSELVSKLRSS-------------IYNGISTSGLDLNNGTIADMRQ 484 Query: 515 ENIYDMLATKKFAINVATEAATTVLSIDQIIMAK 548 I + K+ ++ A+EAA +L +D II A+ Sbjct: 485 LGIVESYKLKRAVVSSASEAAEVLLRVDNIIRAR 518 >4V8R-AG nrPDB Length = 590 Score = 127 bits (320), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 102/350 (29%), Positives = 179/350 (51%), Gaps = 11/350 (3%) Query: 29 IKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVHPAVKVLVMA 88 I +I A + + + T +GP K++++ +G +++TND +LRE+D+ HPA K ++ Sbjct: 22 ISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTNDGHAILREIDVAHPAAKSMLEL 81 Query: 89 TEQQKIDMGDGTNLVMILAGELL-NVSEKLISMGLSAVEIIQGYNMARKFTLKELDEMVV 147 + Q ++GDGT V+ILAGE+L + LI + V IIQ A L+ + + V Sbjct: 82 SRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVIIIQALKKALTDALEVIKQ--V 139 Query: 148 GEITDKNDKNELLKMIKPVISSKK--YGSEDILSELVSEAVSHVLP-VAQQAGEIPYFNV 204 + D + + K+I+ I +K + SE + EL +AV V + Q P F + Sbjct: 140 SKPVDVENDAAMKKLIQASIGTKYVIHWSEK-MCELALDAVKTVRKDLGQTVEGEPNFEI 198 Query: 205 D---SIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFTCPLDIANTET 261 D +RV KI GG + +S V+KG++ N++ H K + +V + CPL+ E+ Sbjct: 199 DIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVV-HPKMSRHIENPRVVLLDCPLEYKKGES 257 Query: 262 KGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGELALHYLNRYGILVL 321 + + + ++ + EE+Q+ M ++I + ++ GV +LA HYL + G VL Sbjct: 258 QTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVITEKGVSDLAQHYLLKGGCSVL 317 Query: 322 KVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGDRVTVF 371 + K + R+ RV GAT + R+ ++G + +E+ GD F Sbjct: 318 RRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKVEMIGDEYFSF 367 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 49/168 (29%), Positives = 87/168 (51%), Gaps = 17/168 (10%) Query: 380 RTSTIILRGATQNNLDDIERAIDDGVAAVKGLM-KPSGGKLLPGAGATEIELISRITKYG 438 + TI+LRG +++ L++I+R + D +A + +M PS L PG GATE+ + ++ + Sbjct: 431 KACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPS---LSPGGGATEMAVSVKLAEKA 487 Query: 439 ERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPGAVKTDHLYKG 498 ++ G+ Q + A A E +PRTL + AG D +L L A H + G Sbjct: 488 KQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKH--------AQGNFTTG 539 Query: 499 VDIDGESDEG-VKDIREENIYDMLATKKFAINVATEAATTVLSIDQII 545 +D D+G + D+ I++ K+ ++ A E+A +L +D I+ Sbjct: 540 ID----GDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIV 583 >5X9V-A nrPDB Length = 521 Score = 118 bits (296), Expect = 6e-27, Method: Compositional matrix adjust. Identities = 128/532 (24%), Positives = 237/532 (44%), Gaps = 54/532 (10%) Query: 28 IIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVHPAVKVLVM 87 + + AA++ L Q+ S+GP G + ++V+ G++++TND T+L +D HPA +++V Sbjct: 17 LFSNAAAVKALTQVVANSLGPKGLDAMLVDRFGEVVVTNDGVTILTLMDAQHPAARMVVN 76 Query: 88 ATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNMA--RKFTLKELDEM 145 Q+ ++GDGT +LAG L++ I G+ +++ G N A L + + Sbjct: 77 MARAQEREVGDGTTTAAVLAGALVSEGVNQILKGVPVSKVLAGMNRALNHALFLIRKNAI 136 Query: 146 VVGEITDKNDKNELLKMIKPVISSKKYGSEDILSELVSEAVSHVLPVAQQAGEIPYFNVD 205 VG ITD + + ++K G D E V+ + + + + P F + Sbjct: 137 KVGSITDD----------RLLAAAKIAGRGD---ERVAAILRDAAAMLEDKLQDPGFKLA 183 Query: 206 SIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFTCPLDIANTETKGTV 265 + + K+ +++T+I G+V N+ P S K +V + + E + Sbjct: 184 DLVLAKVG----ADTTLIPGVVINKSPLWEEGS---QKLQEVRLLVLDDGLYPEEVEEEA 236 Query: 266 LLHNA--QEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGELALHYLNRYGILVLKV 323 L A ++ L +K +K++ ++GV+ I+ G+ ++A + I+V+ Sbjct: 237 LASEAGFEQYLK----NQKIFQENLKKLKELGVKLILLTRGISDIAEEFCYENEIMVITR 292 Query: 324 PSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGDRVTVFKQ-------EQG 376 ++ EL+R+ GA R P VE ++ M +G R + E G Sbjct: 293 ITQKELKRVLEFTGARAAKRTSLNKP-----VEELQKM-LGYARTCFYDSRLDFTIIEGG 346 Query: 377 EISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATEIELISRITK 436 T+T+++ AT +D+ ER D + + +LPG GA + L + Sbjct: 347 AGKATATVLIGAATDEVVDEQERIAKDAAGSFAAAYRSG---VLPGGGAFFLYLSREVES 403 Query: 437 YGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPGAVKTDHLY 496 R PG+ + F+ A +V R +AE AG + E L +L V+ ++ Sbjct: 404 LKNRLPGMESYGVMAFSEALKVPFRVMAENAGFNGLEKLGDLMTLQ-------VQKNNYA 456 Query: 497 KGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQIIMAK 548 G+D E+ E + D+ + D A+ A+E A ++L I+ II K Sbjct: 457 LGLDF--ETGEFI-DMIAGGVVDPAEVVYQAVKNASEVAISLLKINTIIKMK 505 >1ASS-A nrPDB Length = 159 Score = 69.3 bits (168), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 43/145 (29%), Positives = 74/145 (51%), Gaps = 1/145 (0%) Query: 225 GMVFNREPEGHVKSLSEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQI 284 G+V ++E + H K K K+A+ L+I TE + V + + ++ DF E Sbjct: 3 GIVIDKE-KVHSKMPDVVKNAKIALIDSALEIKKTEIEAKVQISDPSKIQDFLNQETNTF 61 Query: 285 DAMMKEIADMGVECIVAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRL 344 M+++I G ++ G+ ++A HYL + GI ++ K ++ +L + GA + L Sbjct: 62 KQMVEKIKKSGANVVLCQKGIDDVAQHYLAKEGIYAVRRVKKSDMEKLAKATGAKIVTDL 121 Query: 345 GAPTPEELGLVETVKTMEIGGDRVT 369 TP LG ETV+ +IG DR+T Sbjct: 122 DDLTPSVLGEAETVEERKIGDDRMT 146 >1E0R-B nrPDB Length = 159 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 32/127 (25%), Positives = 65/127 (51%) Query: 243 KKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAG 302 K K+A+ PL+I E + + + + F EE + M+ +I +G ++ Sbjct: 20 KDAKIALLDAPLEIKKPEFDTNLRIEDPSMIQKFLAQEENMLREMVDKIKSVGANVVITQ 79 Query: 303 AGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTME 362 G+ ++A HYL+R GI ++ K ++ +L + GA+ + + + +LG E V+ ++ Sbjct: 80 KGIDDMAQHYLSRAGIYAVRRVKKSDMDKLAKATGASIVSTIDEISSSDLGTAERVEQVK 139 Query: 363 IGGDRVT 369 +G D +T Sbjct: 140 VGEDYMT 146 >1GN1-A nrPDB Length = 178 Score = 53.1 bits (126), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 43/183 (23%), Positives = 85/183 (46%), Gaps = 20/183 (10%) Query: 217 LSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDF 276 + +S V++G++ N++ H + K ++ + L+ E++ + + ++ Sbjct: 1 MEDSCVLRGVMINKDV-THPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRI 59 Query: 277 SKGEEKQIDAMMKEIADMGVECIVAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVC 336 + EE+ I + ++I + + ++ G+ +LA HYL R + ++ K + R+ R C Sbjct: 60 LQMEEEYIHQLCEDIIQLKPDVVITEKGISDLAQHYLMRANVTAIRRVRKTDNNRIARAC 119 Query: 337 GATPLPRLGAPTPEEL---------GLVETVKTMEIGGDRVTVFKQEQGEISRTSTIILR 387 GA + R PEEL GL+E K GD F + + + TI+LR Sbjct: 120 GARIVSR-----PEELREDDVGTGAGLLEIKKI----GDEYFTFITDCKD-PKACTILLR 169 Query: 388 GAT 390 GA+ Sbjct: 170 GAS 172 >5CDI-A nrPDB Length = 552 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 47/174 (27%), Positives = 84/174 (48%), Gaps = 14/174 (8%) Query: 21 YSNADGQIIKSI-AAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVH 79 + N D Q +K + A + +L + ++GP GRN ++ + G I ND T+ RE+++ Sbjct: 6 HFNKDMQALKRMQAGVDKLATVVGVTIGPKGRNVVLESKFGAPKIVNDGVTIAREVELSD 65 Query: 80 P----AVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNMAR 135 P ++ A + GDGT +L+ + K++S G + V++++G Sbjct: 66 PVENIGATLVRQAAARTNDTAGDGTTTATVLSAAFIAEGMKIVSAGTNPVQLVRGMEKTV 125 Query: 136 KFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGSEDILSELVSEAVSHV 189 + +KEL +M TDK+ N V G+ DI S L+S+A++ V Sbjct: 126 QELVKELRKMSSVVQTDKDLAN--------VACVSAGGNTDIGS-LISDAMAKV 170 >5DA8-A nrPDB Length = 545 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 30/113 (26%), Positives = 54/113 (47%), Gaps = 6/113 (5%) Query: 35 IRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVHP-----AVKVLVMAT 89 + +L ++GP GRN +I G T D T+ +E+++V P A V +A+ Sbjct: 20 VDKLANAVKVTLGPAGRNVLIDKKFGAPTSTKDGVTVAKEIELVDPVENMGAQMVREVAS 79 Query: 90 EQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNMARKFTLKEL 142 + + GDGT +LA + K ++ G +++ +G + A K + EL Sbjct: 80 KTSDV-AGDGTTTATVLAQAIYREGLKNVTAGARPIDLKRGIDRAVKEVVAEL 131 >4PJ1-A nrPDB Length = 558 Score = 38.9 bits (89), Expect = 0.007, Method: Compositional matrix adjust. Identities = 30/109 (27%), Positives = 46/109 (42%), Gaps = 4/109 (3%) Query: 38 LHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVHP----AVKVLVMATEQQK 93 L +MGP GR II G +T D T+ + +D+ K++ Sbjct: 49 LADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTN 108 Query: 94 IDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNMARKFTLKEL 142 + GDGT +LA + + IS G + VEI +G +A + EL Sbjct: 109 EEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAEL 157 >4AAR-A nrPDB Length = 548 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 26/123 (21%), Positives = 58/123 (47%), Gaps = 4/123 (3%) Query: 29 IKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDI----VHPAVKV 84 +K + + L ++GP GRN ++ G IT D ++ RE+++ + ++ Sbjct: 14 VKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFENMGAQM 73 Query: 85 LVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNMARKFTLKELDE 144 + + GDGT +LA ++ K ++ G++ +++ +G + A ++EL Sbjct: 74 VKEVASKANDAAGDGTTTATVLAQAIITEGLKAVAAGMNPMDLKRGIDKAVTAAVEELKA 133 Query: 145 MVV 147 + V Sbjct: 134 LSV 136 >1IOK-A nrPDB Length = 545 Score = 36.6 bits (83), Expect = 0.034, Method: Compositional matrix adjust. Identities = 22/101 (21%), Positives = 49/101 (48%), Gaps = 4/101 (3%) Query: 38 LHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVHP----AVKVLVMATEQQK 93 L ++GP GRN +I G IT D ++ +E+++ +++ + Sbjct: 23 LADAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEIELSDKFENMGAQMVREVASRTN 82 Query: 94 IDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNMA 134 + GDGT +LA ++ K ++ G++ +++ +G ++A Sbjct: 83 DEAGDGTTTATVLAQAIVREGLKAVAAGMNPMDLKRGIDVA 123 >4V4O-A nrPDB Length = 543 Score = 32.7 bits (73), Expect = 0.48, Method: Compositional matrix adjust. Identities = 22/107 (20%), Positives = 51/107 (47%), Gaps = 4/107 (3%) Query: 45 SMGPCGRNKIIVNHLGKIIITNDAATMLRELD----IVHPAVKVLVMATEQQKIDMGDGT 100 ++GP GRN ++ G IT D T+ +E++ + + ++L + GDGT Sbjct: 29 TLGPRGRNVVLEKKFGSPTITKDGVTVAKEVELEDHLENIGAQLLKEVASKTNDVAGDGT 88 Query: 101 NLVMILAGELLNVSEKLISMGLSAVEIIQGYNMARKFTLKELDEMVV 147 +LA ++ K ++ G + + + +G A + ++++ + + Sbjct: 89 TTATVLAQAIVREGLKNVAAGANPLALKRGIEKAVEAAVEKIKALAI 135 >5A1Y-E nrPDB Length = 874 Score = 30.0 bits (66), Expect = 3.0, Method: Compositional matrix adjust. Identities = 25/99 (25%), Positives = 38/99 (38%), Gaps = 11/99 (11%) Query: 244 KHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVEC----- 298 KH AV C LD+ N T + G E ID +MK+I+ E Sbjct: 317 KHPSAVTACNLDLENLVTDSNRSIATLAITTLLKTGSESSIDRLMKQISSFMSEISDEFK 376 Query: 299 IVAGAGVGELALHYLNRYGIL------VLKVPSKFELRR 331 +V + L Y ++ +L +L+ FE +R Sbjct: 377 VVVVQAISALCQKYPRKHAVLMNFLFTMLREEGGFEYKR 415 >3BU8-A nrPDB Length = 235 Score = 29.3 bits (64), Expect = 4.3, Method: Compositional matrix adjust. Identities = 19/72 (26%), Positives = 35/72 (48%), Gaps = 9/72 (12%) Query: 27 QIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIIT----NDAATMLRELDIVHPAV 82 +++K A I +C+ + +KI+ H+ K T ND ++RE ++ HP + Sbjct: 114 KLVKEAAVI-----ICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPVI 168 Query: 83 KVLVMATEQQKI 94 + T QQK+ Sbjct: 169 QNFSYETFQQKM 180 >2Q8N-A nrPDB Length = 460 Score = 29.3 bits (64), Expect = 4.9, Method: Compositional matrix adjust. Identities = 22/65 (33%), Positives = 35/65 (53%), Gaps = 8/65 (12%) Query: 255 DIANTETKGTVLLHNAQEML-DFSKGEEKQIDAMMKEIAD--MGVECIV----AGAGVGE 307 D+ + E K T + N E DF+K + ID++ K + D + + +V G+G+G Sbjct: 35 DVKSVEEKVTSAVRNFVENTPDFAKLDRSWIDSV-KSLEDWIINFDTVVVLGIGGSGLGN 93 Query: 308 LALHY 312 LALHY Sbjct: 94 LALHY 98 >3VSD-A nrPDB Length = 389 Score = 29.3 bits (64), Expect = 5.1, Method: Compositional matrix adjust. Identities = 22/86 (25%), Positives = 38/86 (44%), Gaps = 7/86 (8%) Query: 428 IELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGL-------DVNEVLPNLYA 480 +E+ISR+++ E+ + F VA V R A + + ++LP L Sbjct: 132 VEIISRLSRRVEKGSLVADATSSNFGVALSAVARLYGYRARVYLPGAAEEFGKLLPRLLG 191 Query: 481 AHNVTEPGAVKTDHLYKGVDIDGESD 506 A + +P A T HL V D +++ Sbjct: 192 AQVIVDPEAPSTVHLLPRVMKDSKNE 217 >5Y58-B nrPDB Length = 628 Score = 29.3 bits (64), Expect = 5.2, Method: Compositional matrix adjust. Identities = 15/44 (34%), Positives = 27/44 (61%) Query: 156 KNELLKMIKPVISSKKYGSEDILSELVSEAVSHVLPVAQQAGEI 199 K+ LK+++ + +S+ Y ++L E+ S A S V PV +GE+ Sbjct: 172 KSNWLKLVEAIPNSRIYNMNELLVEITSPATSVVKPVRVFSGEL 215 >5MDW-r nrPDB Length = 118 Score = 28.9 bits (63), Expect = 6.3, Method: Compositional matrix adjust. Identities = 17/56 (30%), Positives = 24/56 (42%) Query: 242 DKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVE 297 D KH V T + T +K + E + S+ E QID + E+A VE Sbjct: 11 DHKHAVIALTSIYGVGKTRSKAILAAAGIAEDVKISELSEGQIDTLRDEVAKFVVE 66 >4M7C-A nrPDB Length = 200 Score = 28.5 bits (62), Expect = 8.4, Method: Compositional matrix adjust. Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 9/75 (12%) Query: 24 ADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIIT----NDAATMLRELDIVH 79 + +++K A I +C+ + +KI+ H+ K T ND ++RE ++ H Sbjct: 108 SSRKLVKEAAVI-----ICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAH 162 Query: 80 PAVKVLVMATEQQKI 94 P ++ T QQK+ Sbjct: 163 PVIQNFSYETFQQKM 177 >3KLJ-A nrPDB Length = 385 Score = 28.1 bits (61), Expect = 9.6, Method: Compositional matrix adjust. Identities = 24/110 (21%), Positives = 51/110 (46%), Gaps = 18/110 (16%) Query: 373 QEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATEIELIS 432 +E G++ R+S +I + NLD I+ D +A+ +G++ + +I Sbjct: 212 EEMGDLIRSSCVITAVGVKPNLDFIK---DTEIASKRGILVNDHME----TSIKDIYACG 264 Query: 433 RITKYGERTPGLLQLAIKQFAVA-----------FEVVPRTLAETAGLDV 471 + ++ + PGL+ +A KQ VA E++P + + +G+ + Sbjct: 265 DVAEFYGKNPGLINIANKQGEVAGLNACGEDASYSEIIPSPILKVSGISI 314 >1NRX-A nrPDB Length = 393 Score = 28.1 bits (61), Expect = 10.0, Method: Compositional matrix adjust. Identities = 23/90 (25%), Positives = 41/90 (45%), Gaps = 7/90 (7%) Query: 21 YSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKII--ITND-AATMLRELDI 77 Y+ G++ KS ++ L+ PCGR+ +++ G +I +T A+T +R + Sbjct: 75 YNRPPGEVSKSRQTKADIEDWMLSQNPPCGRDTVVIALGGGVIGDLTGFVASTYMRGVRY 134 Query: 78 VHPAVKVLVMATE----QQKIDMGDGTNLV 103 V +L M + ID G NL+ Sbjct: 135 VQVPTTLLAMVDSSIGGKTAIDTPLGKNLI 164 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5GW5-q nrPDB 655 0.0 4XCG-B nrPDB 586 e-168 3J1E-A nrPDB 585 e-167 3J1C-A nrPDB 583 e-167 1Q3S-A nrPDB 580 e-166 1A6E-A nrPDB 579 e-166 4XCI-A nrPDB 572 e-163 4B2T-Q nrPDB 569 e-163 3RUW-A nrPDB 565 e-161 5UYZ-A nrPDB 558 e-159 1A6D-B nrPDB 557 e-159 5GW4-h nrPDB 555 e-158 4B2T-G nrPDB 550 e-157 4B2T-H nrPDB 545 e-155 4V8R-AE nrPDB 539 e-153 3IYF-A nrPDB 533 e-152 4B2T-A nrPDB 529 e-150 4B2T-D nrPDB 527 e-150 3AQ1-B nrPDB 526 e-149 5GW5-g nrPDB 516 e-146 5GW4-d nrPDB 505 e-143 4V94-A nrPDB 496 e-140 5GW5-z nrPDB 489 e-138 4B2T-Z nrPDB 483 e-137 4B2T-B nrPDB 478 e-135 4V8R-AB nrPDB 470 e-133 5X9V-A nrPDB 389 e-108 4V8R-AG nrPDB 355 4e-98 1GN1-A nrPDB 186 2e-47 1E0R-B nrPDB 178 6e-45 1ASS-A nrPDB 176 3e-44 5CDI-A nrPDB 160 2e-39 5DA8-A nrPDB 135 7e-32 Sequences not found previously or not previously below threshold: 4V4O-A nrPDB 176 3e-44 1IOK-A nrPDB 145 3e-35 4PJ1-A nrPDB 137 1e-32 4AAR-A nrPDB 135 5e-32 1SJP-A nrPDB 126 3e-29 3LXD-A nrPDB 40 0.003 3E0V-A nrPDB 38 0.011 4PLW-A nrPDB 37 0.027 2GJN-A nrPDB 34 0.18 3LFI-A nrPDB 33 0.38 4KRZ-A nrPDB 32 0.62 4N7R-A nrPDB 32 0.67 4FLV-A nrPDB 32 0.69 3OLJ-A nrPDB 32 1.0 5H12-A nrPDB 32 1.0 3L6X-A nrPDB 31 1.3 3GEE-A nrPDB 31 1.6 2VHI-A nrPDB 31 1.6 4A61-A nrPDB 31 1.8 3OZ2-A nrPDB 30 2.1 2ZVC-A nrPDB 30 3.9 3D31-A nrPDB 29 4.5 4CBQ-A nrPDB 29 4.9 2GF2-A nrPDB 29 7.0 1UF2-K nrPDB 28 7.2 2IOU-G nrPDB 28 7.6 4PLF-A nrPDB 28 9.8 >5GW5-q nrPDB Length = 568 Score = 655 bits (1689), Expect = 0.0, Method: Composition-based stats. Identities = 568/568 (100%), Positives = 568/568 (100%) Query: 1 MSLRLPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLG 60 MSLRLPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLG Sbjct: 1 MSLRLPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLG 60 Query: 61 KIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISM 120 KIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISM Sbjct: 61 KIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISM 120 Query: 121 GLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGSEDILSE 180 GLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGSEDILSE Sbjct: 121 GLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGSEDILSE 180 Query: 181 LVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLS 240 LVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLS Sbjct: 181 LVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLS 240 Query: 241 EDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIV 300 EDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIV Sbjct: 241 EDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIV 300 Query: 301 AGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKT 360 AGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKT Sbjct: 301 AGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKT 360 Query: 361 MEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLL 420 MEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLL Sbjct: 361 MEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLL 420 Query: 421 PGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYA 480 PGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYA Sbjct: 421 PGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYA 480 Query: 481 AHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLS 540 AHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLS Sbjct: 481 AHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLS 540 Query: 541 IDQIIMAKKAGGPRAPQGPRPGNWDQED 568 IDQIIMAKKAGGPRAPQGPRPGNWDQED Sbjct: 541 IDQIIMAKKAGGPRAPQGPRPGNWDQED 568 >4XCG-B nrPDB Length = 557 Score = 586 bits (1510), Expect = e-168, Method: Composition-based stats. Identities = 159/551 (28%), Positives = 286/551 (51%), Gaps = 22/551 (3%) Query: 6 PQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIIT 65 P+ + K+G + + + +IAA++ + + ++ GP G +K++V+ LG I IT Sbjct: 13 PEGIPVIILKEGSSRTYGKEA-LRANIAAVKAIEEALKSTYGPRGMDKMLVDSLGDITIT 71 Query: 66 NDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAV 125 ND AT+L ++D+ HP K+LV + Q + DGT +ILAGEL +E L+ + Sbjct: 72 NDGATILDKMDLQHPTGKLLVQIAKGQDEETADGTKTAVILAGELAKKAEDLLYKEIHPT 131 Query: 126 EIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKY-GSEDILSELVSE 184 I+ GY A + LK + E+ + ND + L K+ + SK G+ + L++LV + Sbjct: 132 IIVSGYKKAEEIALKTIQEIA--QPVTINDTDVLRKVALTSLGSKAVAGAREYLADLVVK 189 Query: 185 AVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKK 244 AV+ V A+ G+ Y ++D++++VK GGS++++ ++ G+V ++E H + Sbjct: 190 AVAQV---AELRGDKWYVDLDNVQIVKKHGGSVNDTQLVYGIVVDKEVV-HPGMPKRIEN 245 Query: 245 HKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAG 304 K+A+ L++ E + +++ +M F + EE + + +IA G ++ G Sbjct: 246 AKIALLDASLEVEKPELDAEIRINDPTQMHKFLEEEENILKEKVDKIAATGANVVICQKG 305 Query: 305 VGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIG 364 + E+A HYL + GIL ++ K +L +L R G + + T ++LG V+ ++G Sbjct: 306 IDEVAQHYLAKKGILAVRRAKKSDLEKLARATGGRVISNIDELTSQDLGYAALVEERKVG 365 Query: 365 GDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAG 424 D++ E + ++ +I++RG + +D+ ERA+ D + V +++ G+ + G G Sbjct: 366 EDKMVFV--EGAKNPKSVSILIRGGLERVVDETERALRDALGTVADVIRD--GRAVAGGG 421 Query: 425 ATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNV 484 A EIE+ R+ KY + G QLAI+ +A A E + LAE AGLD + L L + H Sbjct: 422 AVEIEIAKRLRKYAPQVGGKEQLAIEAYANAIEGLIMILAENAGLDPIDKLMQLRSLHEN 481 Query: 485 TEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQI 544 + + G+++ + E D+ + + + K A+ ATEA T VL ID I Sbjct: 482 E-------TNKWYGLNLFTGNPE---DMWKLGVIEPALVKMNAVKAATEAVTLVLRIDDI 531 Query: 545 IMAKKAGGPRA 555 + A K G Sbjct: 532 VAAGKKSGSEP 542 >3J1E-A nrPDB Length = 553 Score = 585 bits (1508), Expect = e-167, Method: Composition-based stats. Identities = 157/564 (27%), Positives = 290/564 (51%), Gaps = 25/564 (4%) Query: 6 PQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIIT 65 P+ + K+G + + + +IAA++ + + ++ GP G +K++V+ LG I IT Sbjct: 11 PEGIPVIILKEGSSRTYGKEA-VRANIAAVKAVEEALKSTYGPRGMDKMLVDSLGDITIT 69 Query: 66 NDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAV 125 ND AT+L ++D+ HPA K+LV + Q + DGT +I +GEL+ +E L+ + Sbjct: 70 NDGATILDKMDLQHPAAKLLVQIAKGQDEETADGTKTAVIFSGELVKKAEDLLYKDVHPT 129 Query: 126 EIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKY-GSEDILSELVSE 184 II GY A + L+ + E+ + ND + L K+ +SSK G+ + ++++V + Sbjct: 130 IIISGYKKAEEVALQTIQELA--QTVSINDTDLLRKIAMTSLSSKAVAGAREYIADIVVK 187 Query: 185 AVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKK 244 AV+ V A+ G+ Y ++D+I++VK GGS++++ ++ G+V ++E H + Sbjct: 188 AVTQV---AELRGDKWYVDLDNIQIVKKAGGSINDTQLVYGIVVDKEVV-HPGMPKRLEN 243 Query: 245 HKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAG 304 K+A+ L++ E + +++ +M F EE I + +I G I+ G Sbjct: 244 AKIALIDASLEVEKPELDAEIRINDPTQMQKFLDEEENLIKEKVDKILATGANVIICQKG 303 Query: 305 VGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIG 364 + E+A YL + G+L ++ K +L +L R G + + + ++LG ++ ++G Sbjct: 304 IDEVAQSYLAKKGVLAVRRAKKSDLEKLARATGGRVVSNIDEISEQDLGYASLIEERKVG 363 Query: 365 GDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAG 424 D++ E + ++ +I++RG + +D+ ERA+ D + V ++K G+ + G G Sbjct: 364 EDKMVFV--EGAKNPKSISILIRGGLERLVDETERALRDALGTVADVIKD--GRAIAGGG 419 Query: 425 ATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNV 484 A EIE+ ++ KY + G QLA++ +A A E + L E AG D ++L L + H Sbjct: 420 AVEIEIAKKLRKYAPQVGGKEQLAVEAYANALESLVSILIENAGFDPIDLLMKLRSTHEN 479 Query: 485 TEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQI 544 + + G+D+ D+ ++ + + K AI ATEAAT VL ID + Sbjct: 480 EN-------NKWYGIDLYAGQP---VDMWQKGVIEPALVKMNAIKAATEAATLVLRIDDV 529 Query: 545 IMAKKAGG--PRAPQGP-RPGNWD 565 + A K G + P G +P D Sbjct: 530 VSAGKKSGGESKTPGGANKPSEED 553 >3J1C-A nrPDB Length = 563 Score = 583 bits (1502), Expect = e-167, Method: Composition-based stats. Identities = 158/550 (28%), Positives = 293/550 (53%), Gaps = 21/550 (3%) Query: 5 LPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIII 64 + LFK+G + S D + +I A R L +M +S+GP G +K++++ G + I Sbjct: 1 MSSGVPVLLFKEGTSRNSGRDA-LKNNILAARTLAEMLRSSLGPKGLDKMLIDSFGDVTI 59 Query: 65 TNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSA 124 TND AT+++E++I HPA K+LV A + Q ++GDGT ++LAG L +E L+ + Sbjct: 60 TNDGATIVKEMEIQHPAAKLLVEAAKAQDSEVGDGTTSAVVLAGLFLEKAESLVDQNIHP 119 Query: 125 VEIIQGYNMARKFTLKELDEMV----VGEITDKNDKNELLKMIKPVISSKKYGSEDILSE 180 II+G+ A +L+ L ++ V ++ ++ L K++ +SSK + L++ Sbjct: 120 TIIIEGFKKAFNKSLELLPQLATKVDVSDLNSATARDALKKIVYTTMSSKFMAEGEELNK 179 Query: 181 LVSEAVSHVLPVAQQAGEIPY-FNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSL 239 ++ + V VA+ + Y ++D I++ K GG++ +S +I+G+V ++E H Sbjct: 180 IMDIVIDAVTTVAEPLPDGGYNVSLDLIKIDKKKGGTIEDSQLIRGIVLDKEVV-HAGMP 238 Query: 240 SEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECI 299 +K K+AV L++ E + + + ++ F E K + M+ ++A +G + Sbjct: 239 RRVEKAKIAVLDASLEVEKPEISAKISITSPDQIKAFLDEEAKYLKDMVDKLASIGANVV 298 Query: 300 VAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVK 359 + G+ ++A H+L + GIL ++ + ++ +L + GA + + TPE+LG E V+ Sbjct: 299 ICQKGIDDIAQHFLAKRGILAVRRVKRSDIEKLEKALGARIISSIKDATPEDLGYAELVE 358 Query: 360 TMEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKL 419 ++G D++ E + + I+LRG+ LD+ ER+I+D + +++ ++ + Sbjct: 359 ERKVGNDKMVFI--EGAKNPKAVNILLRGSNDMALDEAERSINDALYSLRNILME--PYI 414 Query: 420 LPGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLY 479 +PG GA E+EL +R+ +Y G QLAI+ +A A E +P LAETAGL+ L +L Sbjct: 415 VPGGGAIELELSARLREYARSVGGKEQLAIEAYADALEEIPMILAETAGLEPISALMDLR 474 Query: 480 AAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVL 539 A H GVD+ + + + DI N+ + + + + ATEAAT+++ Sbjct: 475 ARHAKGLTNC--------GVDV--INGKIIDDIYSINVVEPIRVTRQVLKSATEAATSIM 524 Query: 540 SIDQIIMAKK 549 ID +I A + Sbjct: 525 KIDDLIAASQ 534 >1Q3S-A nrPDB Length = 548 Score = 580 bits (1496), Expect = e-166, Method: Composition-based stats. Identities = 175/551 (31%), Positives = 301/551 (54%), Gaps = 24/551 (4%) Query: 3 LRLPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKI 62 +L P + +G Y D Q + +I A R + + T++GP G +K++V+ LG I Sbjct: 2 AQLSGQP-VVILPEGTQRYVGRDAQRL-NILAARIIAETVRTTLGPKGMDKMLVDSLGDI 59 Query: 63 IITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGL 122 ++TND AT+L ++D+ HPA K++V + Q + GDGT +++AGELL +E+L+ + Sbjct: 60 VVTNDCATILDKIDLQHPAAKMMVEVAKTQDKEAGDGTTTAVVIAGELLRKAEELLDQNI 119 Query: 123 SAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSK-KYGSEDILSEL 181 II+GY +A + + LDE+ + D +D+ LLK+ I+ K +++L++L Sbjct: 120 HPSIIIKGYALAAEKAQEILDEIAIR--VDPDDEETLLKIAATSITGKNAESHKELLAKL 177 Query: 182 VSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSE 241 EAV V A++ ++D+I+ K G + S +++G+V ++E H + Sbjct: 178 AVEAVKQV---AEKKDGKYVVDLDNIKFEKKAGEGVEESELVRGVVIDKEVV-HPRMPKR 233 Query: 242 DKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVA 301 + K+A+ L++ TET + + + +++ F + EEK + M+ IA G + Sbjct: 234 VENAKIALINEALEVKKTETDAKINITSPDQLMSFLEQEEKMLKDMVDHIAQTGANVVFV 293 Query: 302 GAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTM 361 G+ +LA HYL +YGI+ ++ K ++ +L + GA + + TPE+LG E V+ Sbjct: 294 QKGIDDLAQHYLAKYGIMAVRRVKKSDMEKLAKATGAKIVTNVKDLTPEDLGYAEVVEER 353 Query: 362 EIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLP 421 ++ G+ + E + + TI++RG T++ +D++ERA++D V VK +M+ G +LP Sbjct: 354 KLAGENMIFV--EGCKNPKAVTILIRGGTEHVIDEVERALEDAVKVVKDVMED--GAVLP 409 Query: 422 GAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAA 481 GA EIEL R+ +Y ++ G LAI+ FA A +++P+TLAE AGLD E+L + + Sbjct: 410 AGGAPEIELAIRLDEYAKQVGGKEALAIENFADALKIIPKTLAENAGLDTVEMLVKVISE 469 Query: 482 HNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSI 541 H K L G+D+ D+ E+ I + L KK AI A+EAA +L I Sbjct: 470 H--------KNRGLGIGIDVFEGKP---ADMLEKGIIEPLRVKKQAIKSASEAAIMILRI 518 Query: 542 DQIIMAKKAGG 552 D +I AK Sbjct: 519 DDVIAAKATKP 529 >1A6E-A nrPDB Length = 545 Score = 579 bits (1493), Expect = e-166, Method: Composition-based stats. Identities = 177/554 (31%), Positives = 286/554 (51%), Gaps = 29/554 (5%) Query: 1 MSLRLPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLG 60 M+ ++P + K+G + Q +I A + + T++GP G +K++V+ +G Sbjct: 2 MTGQVP----ILVLKEGTQREQGKNAQR-NNIEAAKAIADAVRTTLGPKGMDKMLVDSIG 56 Query: 61 KIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISM 120 III+ND AT+L+E+D+ HP K++V ++ Q +GDGT ++L+GELL +E L+ Sbjct: 57 DIIISNDGATILKEMDVEHPTAKMIVEVSKAQDTAVGDGTTTAVVLSGELLKQAETLLDQ 116 Query: 121 GLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYG-SEDILS 179 G+ I GY +A K +DE+ D L K+ +S K G S D L+ Sbjct: 117 GVHPTVISNGYRLAVNEARKIIDEIA----EKSTDDATLRKIALTALSGKNTGLSNDFLA 172 Query: 180 ELVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSL 239 +LV +AV+ V V + +I+V K GGS++++ I G+V ++E + H K Sbjct: 173 DLVVKAVNAVAEVRDGKT---IVDTANIKVDKKNGGSVNDTQFISGIVIDKE-KVHSKMP 228 Query: 240 SEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECI 299 K K+A+ L+I TE + V + + ++ DF E M+++I G + Sbjct: 229 DVVKNAKIALIDSALEIKKTEIEAKVQISDPSKIQDFLNQETNTFKQMVEKIKKSGANVV 288 Query: 300 VAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVK 359 + G+ ++A HYL + GI ++ K ++ +L + GA + L TP LG ETV+ Sbjct: 289 LCQKGIDDVAQHYLAKEGIYAVRRVKKSDMEKLAKATGAKIVTDLDDLTPSVLGEAETVE 348 Query: 360 TMEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKL 419 +IG DR+T + + +I++RG T + + ++ERA++D + V + GK Sbjct: 349 ERKIGDDRMTFVMG--CKNPKAVSILIRGGTDHVVSEVERALNDAIRVV--AITKEDGKF 404 Query: 420 LPGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLY 479 L G GA E EL R+ KY G QLAI+ FA A E++PRTLAE AG+D L L Sbjct: 405 LWGGGAVEAELAMRLAKYANSVGGREQLAIEAFAKALEIIPRTLAENAGIDPINTLIKLK 464 Query: 480 AAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVL 539 A + GVD+D + GV D++ + + D L K A+ A E AT +L Sbjct: 465 ADDEKG--------RISVGVDLD---NNGVGDMKAKGVVDPLRVKTHALESAVEVATMIL 513 Query: 540 SIDQIIMAKKAGGP 553 ID +I +KK+ P Sbjct: 514 RIDDVIASKKSTPP 527 >4XCI-A nrPDB Length = 559 Score = 572 bits (1475), Expect = e-163, Method: Composition-based stats. Identities = 164/563 (29%), Positives = 291/563 (51%), Gaps = 28/563 (4%) Query: 13 LFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATML 72 L K+G + + D + +I A + L +M +S+GP G +K++++ G + ITND AT++ Sbjct: 7 LLKEGTSRTTGRDA-LRNNILAAKTLAEMLRSSLGPKGLDKMLIDSFGDVTITNDGATIV 65 Query: 73 RELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYN 132 ++++I HPA K+LV A + Q ++GDGT ++LAG LL +E L+ + II+GY Sbjct: 66 KDMEIQHPAAKLLVEAAKAQDAEVGDGTTSAVVLAGALLEKAESLLDQNIHPTIIIEGYK 125 Query: 133 MARKFTLKELDEMV----VGEITDKNDKNELLKMIKPVISSKKYGSEDILSELVSEAVSH 188 A L+ L ++ + ++ ++ L K+ ++SK L++++ + Sbjct: 126 KAYNKALELLPQLGTRIDIKDLNSSVARDTLRKIAFTTLASKFIAEGAELNKIIDMVIDA 185 Query: 189 VLPVAQQAGEIPY-FNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKV 247 ++ VA+ Y ++D I++ K GGS+ +S ++KG+V ++E H K K+ Sbjct: 186 IVNVAEPLPNGGYNVSLDLIKIDKKKGGSIEDSVLVKGLVLDKEVV-HPGMPRRVTKAKI 244 Query: 248 AVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGE 307 AV L++ E + + + +++ F E K + M+ ++A +G ++ G+ + Sbjct: 245 AVLDAALEVEKPEISAKISITSPEQIKAFLDEESKYLKDMVDKLASIGANVVICQKGIDD 304 Query: 308 LALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGDR 367 +A H+L + GIL ++ + ++ +L + GA + + TPE+LG E V+ +G D+ Sbjct: 305 IAQHFLAKKGILAVRRVKRSDIEKLEKALGARIISSIKDATPEDLGYAELVEERRVGNDK 364 Query: 368 VTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATE 427 + E + + I+LRG+ LD+ ER+I+D + A++ ++ +LPG GA E Sbjct: 365 MVFI--EGAKNLKAVNILLRGSNDMALDEAERSINDALHALRNILLE--PVILPGGGAIE 420 Query: 428 IELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEP 487 +EL ++ +Y G QLAI+ FA A E +P LAETAGL+ L +L A H Sbjct: 421 LELAMKLREYARSVGGKEQLAIEAFADALEEIPLILAETAGLEAISSLMDLRARHAKGLS 480 Query: 488 GAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQIIMA 547 GVD+ G + V D+ NI + + K + ATEAAT +L ID +I A Sbjct: 481 N--------TGVDVIG--GKIVDDVYALNIIEPIRVKSQVLKSATEAATAILKIDDLIAA 530 Query: 548 -------KKAGGPRAPQGPRPGN 563 K G + G G+ Sbjct: 531 APLKSEKKGGEGSKEESGGEGGS 553 >4B2T-Q nrPDB Length = 548 Score = 569 bits (1467), Expect = e-163, Method: Composition-based stats. Identities = 258/569 (45%), Positives = 372/569 (65%), Gaps = 22/569 (3%) Query: 1 MSLRLPQNPN-AGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHL 59 M+L +P+ P A + K+G +S + + ++I A +EL Q T+ GP G NK+++NHL Sbjct: 1 MALHVPKAPGFAQMLKEGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHL 60 Query: 60 GKIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLIS 119 K+ +TNDAAT+LREL++ HPA K++VMA+ Q+ ++GDGTN V++ AG LL ++E+L+ Sbjct: 61 EKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLR 120 Query: 120 MGLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGSEDILS 179 +GLS E+I+GY +A K + L ++V + D +E+ ++ + SK+YG+E L+ Sbjct: 121 LGLSVSEVIEGYEIACKKAHEILPDLVCCSAKNLRDVDEVSSLLHTSVMSKQYGNEVFLA 180 Query: 180 ELVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSL 239 +L+++A + P + +FNVD+IRV KI+G + +S+V+ GMVF +E EG V S Sbjct: 181 KLIAQACVSIFP------DSGHFNVDNIRVCKILGSGVHSSSVLHGMVFKKETEGDVTS- 233 Query: 240 SEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECI 299 K K+AV++CP D TETKGTVL+ +A+E+++FSKGEE +DA +K IAD G + Sbjct: 234 --VKDAKIAVYSCPFDGMITETKGTVLIKSAEELMNFSKGEENLMDAQVKAIADTGANVV 291 Query: 300 VAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVK 359 V G V ++ALHY N+Y I+++++ SK++LRRLC+ GAT LPRL P EE+G ++V Sbjct: 292 VTGGRVADMALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLNPPVLEEMGHCDSVY 351 Query: 360 TMEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKL 419 E+G +V VFK E+ E STI+LRG+T N +DDIERA+DDGV K L + +L Sbjct: 352 LSEVGDTQVVVFKHEK-EDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDK--RL 408 Query: 420 LPGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLY 479 +PG GATEIEL +IT YGE PGL Q AIK+FA AFE +PR LAE +G+ NEV+ LY Sbjct: 409 VPGGGATEIELAKQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLY 468 Query: 480 AAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVL 539 A H G+DI+ E VKD+ E + D K +AI +AT AA TVL Sbjct: 469 AVHQEGNKN--------VGLDIEAEV-PAVKDMLEAGVLDTYLGKYWAIKLATNAAVTVL 519 Query: 540 SIDQIIMAKKAGGPRAPQGPRPGNWDQED 568 +DQIIMAK AGGP+ P G + + DQ D Sbjct: 520 RVDQIIMAKPAGGPKPPSGKKDWDEDQND 548 >3RUW-A nrPDB Length = 543 Score = 565 bits (1455), Expect = e-161, Method: Composition-based stats. Identities = 161/550 (29%), Positives = 295/550 (53%), Gaps = 27/550 (4%) Query: 5 LPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIII 64 + Q P G+ + Y D Q + +I A R + + +++GP G +K++V+ LG +++ Sbjct: 1 MSQQP--GVLPENMKRYMGRDAQRM-NILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVV 57 Query: 65 TNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSA 124 TND T+LRE+ + HPA K+L+ + Q+ ++GDGT +++AGELL +E+L+ + Sbjct: 58 TNDGVTILREMSVEHPAAKMLIEVAKTQEKEVGDGTTTAVVVAGELLRKAEELLDQNVHP 117 Query: 125 VEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSK-KYGSEDILSELVS 183 +++GY A + + L + DK L K+ I+ K +++ L+E++ Sbjct: 118 TIVVKGYQAAAQKAQELLKTIACE--VGAQDKEILTKIAMTSITGKGAEKAKEKLAEIIV 175 Query: 184 EAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDK 243 EAVS V+ + + D I++ K G S+ ++ +IKG++ ++E + + Sbjct: 176 EAVSAVVD------DEGKVDKDLIKIEKKSGASIDDTELIKGVLVDKE-RVSAQMPKKVT 228 Query: 244 KHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGA 303 K+A+ C ++I TET + + + ++++F + EEK + M+ EI G + Sbjct: 229 DAKIALLNCAIEIKETETDAEIRITDPAKLMEFIEQEEKMLKDMVAEIKASGANVLFCQK 288 Query: 304 GVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEI 363 G+ +LA HYL + GI+ + K ++ +L + GA + + A + ++LG V+ +I Sbjct: 289 GIDDLAQHYLAKEGIVAARRVKKSDMEKLAKATGANVIAAIAALSAQDLGDAGLVEERKI 348 Query: 364 GGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGA 423 GD + E+ + + T+++RG T++ ++++ RA+DD V V ++ G+++ G Sbjct: 349 SGDSMIFV--EECKHPKAVTMLIRGTTEHVIEEVARAVDDAVGVVGCTIED--GRIVSGG 404 Query: 424 GATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHN 483 G+TE+EL ++ +Y E G QLA++ FA A EV+PRTLAE AGLD E+L + AAH Sbjct: 405 GSTEVELSMKLREYAEGISGREQLAVRAFADALEVIPRTLAENAGLDAIEILVKVRAAH- 463 Query: 484 VTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQ 543 + +++ G V+D+ E + + L K AI A E+ +L ID Sbjct: 464 ASNGNKCAGLNVFTG---------AVEDMCENGVVEPLRVKTQAIQSAAESTEMLLRIDD 514 Query: 544 IIMAKKAGGP 553 +I A+K G Sbjct: 515 VIAAEKLRGA 524 >5UYZ-A nrPDB Length = 541 Score = 558 bits (1438), Expect = e-159, Method: Composition-based stats. Identities = 138/543 (25%), Positives = 272/543 (50%), Gaps = 17/543 (3%) Query: 9 PNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDA 68 P + Q S + I A + + TS+GP G +K++V+ G + +TND Sbjct: 15 PFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDG 74 Query: 69 ATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEII 128 AT+L +D+ H K++V ++ Q ++GDGT V++LAG LL +E+L+ G+ + I Sbjct: 75 ATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIA 134 Query: 129 QGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGSEDILSELVSEAVSH 188 GY A + ++ LD++ + D D L++ K + SK S ++ AV+ Sbjct: 135 DGYEQAARVAIERLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNS--CHRQMAEIAVNA 192 Query: 189 VLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVA 248 VL VA E + + I+V +GG L ++ +IKG++ +++ H + + + K+A Sbjct: 193 VLTVADM--ERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDF-SHPQMPKKVEDAKIA 249 Query: 249 VFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGEL 308 + TCP + +TK + + + ++ K E+++ + M+++I + G + G + Sbjct: 250 ILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDE 309 Query: 309 ALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGDRV 368 A H L + + ++ E+ + G +PR T E+LG V+ + G + Sbjct: 310 ANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKD 369 Query: 369 TVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATEI 428 + EQ + SR TI +RG + +++ +R++ D + ++ L++ + +++ G GA EI Sbjct: 370 KMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDN--RVVYGGGAAEI 427 Query: 429 ELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPG 488 +++ ++ P L Q A++ FA A EV+P L+E +G++ + + + A Sbjct: 428 SCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNP 487 Query: 489 AVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQIIMAK 548 A+ D L+KG + D++++++ + L KK I++AT+ +L ID I Sbjct: 488 ALGIDCLHKGTN----------DMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPG 537 Query: 549 KAG 551 ++ Sbjct: 538 ESE 540 >1A6D-B nrPDB Length = 543 Score = 557 bits (1436), Expect = e-159, Method: Composition-based stats. Identities = 159/535 (29%), Positives = 282/535 (52%), Gaps = 23/535 (4%) Query: 13 LFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATML 72 + K+G S D + ++I A + +S+GP G +K++V+ LG I+ITND T+L Sbjct: 9 ILKEGTKRESGKDA-MKENIEAAIAISNSVRSSLGPRGMDKMLVDSLGDIVITNDGVTIL 67 Query: 73 RELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYN 132 +E+D+ HPA K++V ++ Q +GDGT +I+AG LL ++ LI+ + I +GY Sbjct: 68 KEMDVEHPAAKMMVEVSKTQDSFVGDGTTTAVIIAGGLLQQAQGLINQNVHPTVISEGYR 127 Query: 133 MARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYG-SEDILSELVSEAVSHVLP 191 MA + + +DE+ D+ K LLKM + ++SK ++D L+E+ EAV V Sbjct: 128 MASEEAKRVIDEISTKIGADE--KALLLKMAQTSLNSKSASVAKDKLAEISYEAVKSV-- 183 Query: 192 VAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFT 251 A+ Y + D+I+VVK GG++ ++ +I G++ ++E + H K K+A+ Sbjct: 184 -AELRDGKYYVDFDNIQVVKKQGGAIDDTQLINGIIVDKE-KVHPGMPDVVKDAKIALLD 241 Query: 252 CPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGELALH 311 PL+I E + + + + F EE + M+ +I +G ++ G+ ++A H Sbjct: 242 APLEIKKPEFDTNLRIEDPSMIQKFLAQEENMLREMVDKIKSVGANVVITQKGIDDMAQH 301 Query: 312 YLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGDRVTVF 371 YL+R GI ++ K ++ +L + GA+ + + + +LG E V+ +++G D +T Sbjct: 302 YLSRAGIYAVRRVKKSDMDKLAKATGASIVSTIDEISSSDLGTAERVEQVKVGEDYMTFV 361 Query: 372 KQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATEIELI 431 + + +I++RG T++ +D++ER+I D + V ++ GAT E+ Sbjct: 362 TG--CKNPKAVSILVRGETEHVVDEMERSITDSLHVVASALEDGAYAAGG--GATAAEIA 417 Query: 432 SRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPGAVK 491 R+ Y ++ G QLAI++FA A E +PR LAE AGLD ++L L A H Sbjct: 418 FRLRSYAQKIGGRQQLAIEKFADAIEEIPRALAENAGLDPIDILLKLRAEHAKGNK---- 473 Query: 492 TDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQIIM 546 G+++ ++D+ + + + + K AI ATEAA +L ID +I Sbjct: 474 ----TYGINVFTG---EIEDMVKNGVIEPIRVGKQAIESATEAAIMILRIDDVIA 521 >5GW4-h nrPDB Length = 550 Score = 555 bits (1431), Expect = e-158, Method: Composition-based stats. Identities = 150/565 (26%), Positives = 270/565 (47%), Gaps = 32/565 (5%) Query: 6 PQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIIT 65 Q P + K+G ++ S GQII +I A + + ++GP G + +IV K I+ Sbjct: 5 SQTPTIVVLKEGTDA-SQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTIS 63 Query: 66 NDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAV 125 ND AT+L+ LD+VHPA K LV + Q ++GDGT V ILAGEL+ ++ + G+S+ Sbjct: 64 NDGATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSH 123 Query: 126 EIIQGYNMARKFTLKELDEMVVGEITDKND-KNELLKMIKPVISSK-KYGSEDILSELVS 183 I++GY A +++++E+ V ++K+ + L + + +SSK + + D ++ Sbjct: 124 LIMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCV 183 Query: 184 EAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREP--EGHVKSLSE 241 +AV + + + I + KI GG++ S I G+ F + G + + Sbjct: 184 DAVLSL--------DRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKK 235 Query: 242 DKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVA 301 K+ L++ + V + + ++ E + I ++++ + G +++ Sbjct: 236 FNNPKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLS 295 Query: 302 GAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTM 361 +G+LA + I S ++ R+ + G + PE LG + M Sbjct: 296 KLPIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEM 355 Query: 362 EIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLP 421 +IG +R +F + ++T T++LRG + + ++ER++ D + VK ++ ++ Sbjct: 356 QIGSERYNLF--QGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNK--LIVA 411 Query: 422 GAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAA 481 G GATE+E+ + Y + G Q+ I FA A EV+PR L E AG D E+L L A Sbjct: 412 GGGATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLA 471 Query: 482 HNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSI 541 H+ E + GV + E+ + D + +++ K A+N ATEA +LS+ Sbjct: 472 HSKGEK--------WYGVVFETEN---IGDNFAKFVWEPALVKINALNSATEATNLILSV 520 Query: 542 DQIIMAKKAGGPR----APQGPRPG 562 D+ I K + PQG G Sbjct: 521 DETITNKGSESANAGMMPPQGAGRG 545 >4B2T-G nrPDB Length = 545 Score = 550 bits (1418), Expect = e-157, Method: Composition-based stats. Identities = 142/552 (25%), Positives = 265/552 (48%), Gaps = 23/552 (4%) Query: 13 LFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATML 72 + Q S Q +I A + + + T +GP K++++ +G I++TND +L Sbjct: 9 VLSQNTKRESGRKVQ-SGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAIL 67 Query: 73 RELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYN 132 RE+ + HPA K ++ + Q ++GDGT V+ILAGE+L+V+E + + +I Y Sbjct: 68 REIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYR 127 Query: 133 MARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGSEDILS-ELVSEAVSHVLP 191 A + L ++ + D ++++ +L +I I++K L+ + +AV V Sbjct: 128 KALDDMISTLKKISI--PVDTSNRDTMLNIINSSITTKVISRWSSLACNIALDAVKTVQF 185 Query: 192 VAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFT 251 EI RV KI GG + +S V++G++ N++ H + K ++ + Sbjct: 186 EENGRKEIDIK--KYARVEKIPGGIIEDSCVLRGVMINKDVT-HPRMRRYIKNPRIVLLD 242 Query: 252 CPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGELALH 311 L+ E++ + + ++ + EE+ I + ++I + + ++ G+ +LA H Sbjct: 243 SSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQH 302 Query: 312 YLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGL-VETVKTMEIGGDRVTV 370 YL R I ++ K + R+ R CGA + R E++G ++ +IG + T Sbjct: 303 YLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREEDVGTGAGLLEIKKIGDEYFTF 362 Query: 371 FKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATEIEL 430 + + + TI+LRGA++ L ++ER + D + + ++ +L+PG GA+E+ + Sbjct: 363 IT--ECKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLD--PQLVPGGGASEMAV 418 Query: 431 ISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPGAV 490 +T+ + G+ Q + A A EV+PRTL + G +L +L A H Sbjct: 419 AHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQEN---- 474 Query: 491 KTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQIIMA-KK 549 + ++GE+ V D++E I++ LA K A E A +L ID I+ KK Sbjct: 475 -----CETWGVNGETGTLV-DMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKK 528 Query: 550 AGGPRAPQGPRP 561 G ++ QG P Sbjct: 529 KGDDQSRQGGAP 540 >4B2T-H nrPDB Length = 543 Score = 545 bits (1405), Expect = e-155, Method: Composition-based stats. Identities = 141/549 (25%), Positives = 260/549 (47%), Gaps = 30/549 (5%) Query: 13 LFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATML 72 L K+G +S S Q++ +I+A + + + T++GP G +K+IV+ GK I+ND AT+L Sbjct: 8 LLKEGTDS-SQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATIL 66 Query: 73 RELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYN 132 + LD+VHPA K LV + Q ++GDGT V +LA E L + + GL II+ + Sbjct: 67 KLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFR 126 Query: 133 MARKFTLKELDEMVVGEITDK--NDKNELLKMIKPVISSKKYGSED-ILSELVSEAVSHV 189 A + + ++ E+ V + + L K +SSK + +++V +AV + Sbjct: 127 TATQLAVNKIKEIAVTVKKEDKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDAVMML 186 Query: 190 LPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDK--KHKV 247 + Q + I + K+ GG+L S ++ G+ F + + K + Sbjct: 187 DDLLQ---------LKMIGIKKVQGGALEESQLVAGVAFKKTFSYAGFEMQPKKYHNPMI 237 Query: 248 AVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGE 307 A+ L++ + + +H ++ E + +++I G + +++ +G+ Sbjct: 238 ALLNVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGD 297 Query: 308 LALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGDR 367 +A Y + + +L+R CG + + A + + LG + + +IGG+R Sbjct: 298 VATQYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALSSDVLGRCQVFEETQIGGER 357 Query: 368 VTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATE 427 F ++T TIILRG + +++ ER++ D + V+ +K ++ G GA E Sbjct: 358 YNFFTG--CPKAKTCTIILRGGAEQFMEETERSLHDAIMIVRRAIKNDS--VVAGGGAIE 413 Query: 428 IELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEP 487 +EL + Y PG QL I +A A E++PR L + AG D +L L A H Sbjct: 414 MELSKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQG-- 471 Query: 488 GAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQIIMA 547 ++ GVDI+ E + D E +++ + A+ A+EAA ++S+D+ I Sbjct: 472 ------GMWYGVDINTED---IADNFEAFVWEPAMVRINALTAASEAACLIVSVDETIKN 522 Query: 548 KKAGGPRAP 556 ++ +P Sbjct: 523 PRSTVDASP 531 >4V8R-AE nrPDB Length = 562 Score = 539 bits (1389), Expect = e-153, Method: Composition-based stats. Identities = 143/550 (26%), Positives = 269/550 (48%), Gaps = 27/550 (4%) Query: 9 PNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDA 68 P + QG + I A R + + TS+GP G +KI+++ G+I ITND Sbjct: 28 PFIIVKDQGNKKRQHGLEAKKSHILAARSVASIIKTSLGPRGLDKILISPDGEITITNDG 87 Query: 69 ATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEII 128 AT+L ++++ + K+LV ++ Q ++GDGT V++LA LL+ + +LI G+ ++I Sbjct: 88 ATILSQMELDNEIAKLLVQLSKSQDDEIGDGTTGVVVLASALLDQALELIQKGIHPIKIA 147 Query: 129 QGYNMARKFTLKELDEMV--VGEITDKNDKNELLKMIKPVISSKKYGSE-DILSELVSEA 185 G++ A K + +L+E + D+ ++ LL+ K + SK + D +E+ EA Sbjct: 148 NGFDEAAKLAISKLEETCDDISASNDELFRDFLLRAAKTSLGSKIVSKDHDRFAEMAVEA 207 Query: 186 VSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSED--- 242 V +V+ + + D I++ +GGS+S+S +I G++ +++ H + Sbjct: 208 VINVMDK-----DRKDVDFDLIKMQGRVGGSISDSKLINGVILDKDF-SHPQMPKCVLPK 261 Query: 243 ---KKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECI 299 K+A+ TCP + +TK + + + +E E+ + M+ ++ G + + Sbjct: 262 EGSDGVKLAILTCPFEPPKPKTKHKLDISSVEEYQKLQTYEQDKFKEMIDDVKKAGADVV 321 Query: 300 VAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVK 359 + G + A H L + + ++ EL + +PR + ++LG + Sbjct: 322 ICQWGFDDEANHLLLQNDLPAVRWVGGQELEHIAISTNGRIVPRFQDLSKDKLGTCSRIY 381 Query: 360 TMEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKL 419 E G + + EQ + ++T T +RG+ + +D+ ERA+ D + V+ L+K S ++ Sbjct: 382 EQEFGTTKDRMLIIEQSKETKTVTCFVRGSNKMIVDEAERALHDSLCVVRNLVKDS--RV 439 Query: 420 LPGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLY 479 + G GA E+ + +++ ++ G+ Q A + FA A + +P TLAE +GLD L L Sbjct: 440 VYGGGAAEVTMSLAVSEEADKQRGIDQYAFRGFAQALDTIPMTLAENSGLDPIGTLSTLK 499 Query: 480 AAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVL 539 + +K GVD G G D++E + D KK I +AT+ +L Sbjct: 500 SKQ-------LKEKISNIGVDCLG---YGSNDMKELFVVDPFIGKKQQILLATQLCRMIL 549 Query: 540 SIDQIIMAKK 549 ID +I++ K Sbjct: 550 KIDNVIISGK 559 >3IYF-A nrPDB Length = 521 Score = 533 bits (1373), Expect = e-152, Method: Composition-based stats. Identities = 153/550 (27%), Positives = 280/550 (50%), Gaps = 49/550 (8%) Query: 5 LPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIII 64 + Q P G+ + Y D Q + +I A R + + +++GP G +K++V+ LG +++ Sbjct: 1 MSQQP--GVLPENMKRYMGRDAQRM-NILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVV 57 Query: 65 TNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSA 124 TND T+LRE+ + HPA K+L+ + Q+ ++GDGT +++AGELL +E+L+ + Sbjct: 58 TNDGVTILREMSVEHPAAKMLIEVAKTQEKEVGDGTTTAVVVAGELLRKAEELLDQNVHP 117 Query: 125 VEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSK-KYGSEDILSELVS 183 +++GY A + + L + DK L K+ I+ K +++ L+E++ Sbjct: 118 TIVVKGYQAAAQKAQELLKTIACE--VGAQDKEILTKIAMTSITGKGAEKAKEKLAEIIV 175 Query: 184 EAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDK 243 EAVS V+ + + D I++ K G S+ ++ +IKG++ ++E + + Sbjct: 176 EAVSAVVD------DEGKVDKDLIKIEKKSGASIDDTELIKGVLVDKE-RVSAQMPKKVT 228 Query: 244 KHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGA 303 K+A+ C ++ +E + M+ EI G + Sbjct: 229 DAKIALLNCAIEETASE----------------------MLKDMVAEIKASGANVLFCQK 266 Query: 304 GVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEI 363 G+ +LA HYL + GI+ + K ++ +L + GA + + + ++LG V+ +I Sbjct: 267 GIDDLAQHYLAKEGIVAARRVKKSDMEKLAKATGANVITNIKDLSAQDLGDAGLVEERKI 326 Query: 364 GGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGA 423 GD + E+ + + T+++RG T++ ++++ RA+DD V V ++ G+++ G Sbjct: 327 SGDSMIFV--EECKHPKAVTMLIRGTTEHVIEEVARAVDDAVGVVGCTIED--GRIVSGG 382 Query: 424 GATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHN 483 G+TE+EL ++ +Y E G QLA++ FA A EV+PRTLAE AGLD E+L + AAH Sbjct: 383 GSTEVELSMKLREYAEGISGREQLAVRAFADALEVIPRTLAENAGLDAIEILVKVRAAH- 441 Query: 484 VTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQ 543 + +++ G V+D+ E + + L K AI A E+ +L ID Sbjct: 442 ASNGNKCAGLNVFTG---------AVEDMCENGVVEPLRVKTQAIQSAAESTEMLLRIDD 492 Query: 544 IIMAKKAGGP 553 +I A+K G Sbjct: 493 VIAAEKLRGA 502 >4B2T-A nrPDB Length = 556 Score = 529 bits (1363), Expect = e-150, Method: Composition-based stats. Identities = 148/545 (27%), Positives = 260/545 (47%), Gaps = 20/545 (3%) Query: 22 SNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVHPA 81 S + +++ A + + +S+GP G +K++V+ +G + ITND AT+L+ L++ HPA Sbjct: 12 STGEAIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLLEVEHPA 71 Query: 82 VKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNMARKFTLKE 141 KVL + Q ++GDGT V+I+A ELL +++L+ + +I GY +A K ++ Sbjct: 72 AKVLCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLACKEAVRY 131 Query: 142 LDEMVVGEITDKNDKNELLKMIKPVISSKKYG-SEDILSELVSEAVSHVLPVAQQAGEIP 200 + E ++ TD+ ++ L+ K +SSK G + D + LV +AV + P Sbjct: 132 ISENLIIN-TDELGRDCLINAAKTSMSSKVIGINGDFFANLVVDAVLAIKYT--DIRGQP 188 Query: 201 YFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFTCPLDIANTE 260 + V+SI V+K G S S +I G N G K+A L + Sbjct: 189 RYPVNSINVLKAHGRSQMESMLINGYALN-CVVGSQGMPKRIVNAKIACLDFSLQKTKMK 247 Query: 261 TKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGELALHYLNRYGILV 320 V++ + +++ + E +++I G I+ G+ ++ L Y G + Sbjct: 248 LGVQVVITDPEKLDQIRQRESDITKERIQKILATGANVILTTGGIDDMCLKYFVEAGAMA 307 Query: 321 LKVPSKFELRRLCRVCGATPLPRLGAPTPEE------LGLVETVKTMEIGGDRVTVFKQE 374 ++ K +L+R+ + GAT L L EE LG E V I D + + K Sbjct: 308 VRRVLKRDLKRIAKASGATVLSTLANLEGEETFEASMLGQAEEVVQERICDDELILIKNT 367 Query: 375 QGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATEIELISRI 434 + S +++ILRGA D++ER++ D + VK +++ ++PG GA E L + Sbjct: 368 KARTS--ASVILRGANDFMCDEMERSLHDALCVVKRVLESKS--VVPGGGAVEAALSIYL 423 Query: 435 TKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPGAVKTDH 494 Y QLAI +FA + V+P TLA A D +++ L A HN + + + Sbjct: 424 ENYATSMGSREQLAIAEFARSLPVIPNTLAVNAAQDSTDLVAKLRAFHNEAQVNPERKNL 483 Query: 495 LYKGVD-IDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQIIMAKKAGGP 553 + G+D ++G+ +D ++ +++ K ++ ATEAA T+L ID +I Sbjct: 484 KWIGLDLVNGKP----RDNKQAGVFEPTIVKVKSLKFATEAAITILRIDDLIKLHPESKD 539 Query: 554 RAPQG 558 G Sbjct: 540 DKHGG 544 >4B2T-D nrPDB Length = 542 Score = 527 bits (1357), Expect = e-150, Method: Composition-based stats. Identities = 144/542 (26%), Positives = 271/542 (50%), Gaps = 30/542 (5%) Query: 16 QGYNSYSNAD--GQI-IKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATML 72 +G ++Y + D QI +I+A + + TS+GP G +K+I + G + ITND AT+L Sbjct: 22 RGKSAYQDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATIL 81 Query: 73 RELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYN 132 +++ ++HPA ++LV ++ Q I+ GDGT V+I+AG LL+ KL+ G+ I + + Sbjct: 82 KQMQVLHPAARMLVELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQ 141 Query: 133 MARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGS-EDILSELVSEAVSHVLP 191 A + ++ L +M + +D+ LL ++SK +LS + +AV V+ Sbjct: 142 KALEKGIEILTDM--SRPVELSDRETLLNSAATSLNSKVVSQYSSLLSPMSVDAVMKVID 199 Query: 192 VAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFT 251 A ++ I++VK +GG++ + +++G+V ++ ++ +K K+ + Sbjct: 200 PATATS----VDLRDIKIVKKLGGTIDDCELVEGLVLTQKVANS--GITRVEKAKIGLIQ 253 Query: 252 CPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGV-----G 306 L T+ +++ + +M + E I ++K+I G ++ + Sbjct: 254 FCLSAPKTDMDNQIVVSDYVQMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALS 313 Query: 307 ELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGD 366 +LALH+LN+ I+V+K + ++ +C+ G P+ + T + LG E + + + G Sbjct: 314 DLALHFLNKMKIMVVKDIEREDIEFICKTIGTKPVAHVDQFTADMLGSAELAEEVSLNGS 373 Query: 367 RVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGAT 426 + +T TI++RG+ + +++ ER+I D + ++ L+K L+ G GA Sbjct: 374 GKLIKITGCASPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRA--LIAGGGAP 431 Query: 427 EIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTE 486 EIEL R+T+Y G+ I+ FA A EV+P TLAE AGL+ + L H E Sbjct: 432 EIELALRLTEYSRTLSGMESYCIRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGE 491 Query: 487 PGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQIIM 546 G+++ G+ +I EE + L A+ +ATE ++L ID ++ Sbjct: 492 K--------TTGINV---RKGGISNILEELVVQPLLVSVSALTLATETVRSILKIDDVVN 540 Query: 547 AK 548 + Sbjct: 541 TR 542 >3AQ1-B nrPDB Length = 500 Score = 526 bits (1354), Expect = e-149, Method: Composition-based stats. Identities = 152/510 (29%), Positives = 277/510 (54%), Gaps = 25/510 (4%) Query: 54 IIVNHLGKIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNV 113 ++V+ +G I+ITND AT+L+E+DI HPA K++V ++ Q ++GDGT +L+GELL+ Sbjct: 1 MLVDSMGDIVITNDGATILKEMDIQHPAAKMIVEVSKTQDAEVGDGTTTAAVLSGELLSK 60 Query: 114 SEKLISMGLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYG 173 +E+LI G+ + I +GY A + + L+ + + +D+ L+K+ I+ K G Sbjct: 61 AEELIMKGVHSTIISEGYRHAAEKCREILETITIA--ISPDDEAALIKIAGTAITGK--G 116 Query: 174 SEDILSELVSEAVSHVLPVAQQAGEIPYFN-VDSIRVVKIMGGSLSNSTVIKGMVFNREP 232 +E +L + V V + ++ + N +++I++ K GGS+ +S +I G+V ++E Sbjct: 117 AEAYKEKLSALTVKAVRSIVEEEEDGLKVNVLENIKIEKRAGGSIDDSELIDGLVIDKE- 175 Query: 233 EGHVKSLSEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIA 292 H + + K+ + +CP++ TE + + + +M F EEK + M +++ Sbjct: 176 RSHPNMPEKVENAKILLLSCPVEFRKTEVDSEIKITSPGQMQLFLDQEEKMMREMAEKVI 235 Query: 293 DMGVECIVAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEEL 352 G + G+ ++A +Y+ + GI ++ K +L+RL +V GAT + L T E++ Sbjct: 236 ASGANVVFCQKGIDDMAQYYIEKAGIYAVRRVKKSDLKRLSKVTGATIIQDLDQITTEDV 295 Query: 353 GLVETVKTMEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLM 412 G V+ E+ G ++T + S+ T++L G T++ +D ++ A++D + V ++ Sbjct: 296 GTAGLVEEKEVRGGKMTYVTG--CQNSKAVTVLLHGGTEHVVDSLDHALNDALHVVGVVI 353 Query: 413 KPSGGKLLPGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVN 472 + GK++ G G++E+EL R+++Y G QLA+ +FA A EV+P LAE AGLD Sbjct: 354 ED--GKVVVGGGSSEVELSLRLSEYASTLKGREQLAVSKFAEALEVIPVALAENAGLDPI 411 Query: 473 EVLPNLYAAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVAT 532 +++ L + H A ++Y G V D+ E ++ + L K AIN A Sbjct: 412 DIMVELRSQHEKGNKNA--GLNVYTG---------EVVDMWENDVIEPLRIKTQAINAAM 460 Query: 533 EAATTVLSIDQIIMAKKAGGPRAPQGPRPG 562 EA +L ID ++ +K + A QG PG Sbjct: 461 EATVMILRIDDVVASKGS----ANQGMGPG 486 >5GW5-g nrPDB Length = 534 Score = 516 bits (1329), Expect = e-146, Method: Composition-based stats. Identities = 147/549 (26%), Positives = 266/549 (48%), Gaps = 24/549 (4%) Query: 8 NPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITND 67 + QI +I A + + + T +GP K++++ +G +++TND Sbjct: 2 QAPVVFMNASQERTTGRQAQI-SNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND 60 Query: 68 AATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNV-SEKLISMGLSAVE 126 +LRE+D+ HPA K ++ + Q ++GDGT V+ILAGE+L + LI + V Sbjct: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 Query: 127 IIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGS-EDILSELVSEA 185 IIQ A L+ + + V + D + + K+I+ I +K + + EL +A Sbjct: 121 IIQALKKALTDALEVIKQ--VSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDA 178 Query: 186 VSHVL-PVAQQAGEIPYFNVD---SIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSE 241 V V + Q P F +D +RV KI GG + +S V+KG++ N++ H K Sbjct: 179 VKTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVV-HPKMSRH 237 Query: 242 DKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVA 301 + +V + CPL+ E++ + + ++ + EE+Q+ M ++I + ++ Sbjct: 238 IENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVIT 297 Query: 302 GAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTM 361 GV +LA HYL + G VL+ K + R+ RV GAT + R+ ++G + + Sbjct: 298 EKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKV 357 Query: 362 EIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLP 421 E+ GD F + + TI+LRG +++ L++I+R + D +A + +M L P Sbjct: 358 EMIGDEYFSFLDN-CKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVM--LSPSLSP 414 Query: 422 GAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAA 481 G GATE+ + ++ + ++ G+ Q + A A E +PRTL + AG D +L L A Sbjct: 415 GGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAK 474 Query: 482 HNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSI 541 H + G+D G+ + + D+ I++ K+ ++ A E+A +L + Sbjct: 475 HAQG--------NFTTGID--GDKGK-IVDMVSYGIWEPEVIKQQSVKTAIESACLLLRV 523 Query: 542 DQIIMAKKA 550 D I+ + Sbjct: 524 DDIVSGVRK 532 >5GW4-d nrPDB Length = 528 Score = 505 bits (1301), Expect = e-143, Method: Composition-based stats. Identities = 144/555 (25%), Positives = 268/555 (48%), Gaps = 34/555 (6%) Query: 1 MSLRLPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLG 60 MS ++P N FK +I A R + TS+GP G +K+I G Sbjct: 1 MSAKVPSNAT---FKNKEKPQEVRKA----NIIAARSVADAIRTSLGPKGMDKMIKTSRG 53 Query: 61 KIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISM 120 +III+ND T+L+++ I+HP ++LV + Q + GDGT V+IL G LL +E+L++ Sbjct: 54 EIIISNDGHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNK 113 Query: 121 GLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGS-EDILS 179 G+ I + A K ++ L EM +D+ +L++ +SSK L+ Sbjct: 114 GIHPTIIADSFQSAAKRSVDILLEM--CHKVSLSDREQLVRAASTSLSSKIVSQYSSFLA 171 Query: 180 ELVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSL 239 L ++V + +++ IR+VK +GG++ ++ +I G+V + Sbjct: 172 PLAVDSVLKISD-----ENSKNVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGP 226 Query: 240 SEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECI 299 + +K K+ + + +T+ +++++ ++M K E + + K+I + Sbjct: 227 TRKEKAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVL 286 Query: 300 VAGAGV-----GELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGL 354 + + +LALH+L++ I+V+K + E+ L + G P+ + T + LG Sbjct: 287 LIQKSILRDAVNDLALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGS 346 Query: 355 VETVKTMEIGGDRVTVFKQEQGEISR-TSTIILRGATQNNLDDIERAIDDGVAAVKGLMK 413 + V+ ++ G ++ + +R T ++++RGA +D+ ER++ D + ++ L+K Sbjct: 347 ADLVEEIDSDGSKIVRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVK 406 Query: 414 PSGGKLLPGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNE 473 G L+ G GA EIE+ R++K G+ ++FA A EV+P TLAE AGL+ + Sbjct: 407 ERG--LIAGGGAPEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIK 464 Query: 474 VLPNLYAAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATE 533 V+ L + H E L G+ + G + EE+I + AI +A+E Sbjct: 465 VVTELRSKHENGE--------LNDGISV---RRSGTTNTYEEHILQPVLVSTSAITLASE 513 Query: 534 AATTVLSIDQIIMAK 548 ++L ID I ++ Sbjct: 514 CVKSILRIDDIAFSR 528 >4V94-A nrPDB Length = 559 Score = 496 bits (1276), Expect = e-140, Method: Composition-based stats. Identities = 147/564 (26%), Positives = 259/564 (45%), Gaps = 21/564 (3%) Query: 4 RLPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKII 63 +L N + G S D + +++ A + + +S+GP G +K++V+ +G Sbjct: 3 QLFNNSRSDTLFLGGEKISGDDIR-NQNVLATMAVANVVKSSLGPVGLDKMLVDDIGDFT 61 Query: 64 ITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLS 123 +TND AT+L LD+ HPA K+LV +QQ ++GDGT V+I+A ELL + +L+ + Sbjct: 62 VTNDGATILSLLDVQHPAGKILVELAQQQDREIGDGTTSVVIIASELLKRANELVKNKIH 121 Query: 124 AVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGSE-DILSELV 182 II G+ +A + ++ ++E V+ D K L+ + K +SSK G++ D S +V Sbjct: 122 PTTIITGFRVALREAIRFINE-VLSTSVDTLGKETLINIAKTSMSSKIIGADSDFFSNMV 180 Query: 183 SEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSED 242 +A+ V Q + + V ++ V+K G S + S ++ G N Sbjct: 181 VDALLAVKT--QNSKGEIKYPVKAVNVLKAHGKSATESLLVPGYALNCTVA-SQAMPKRI 237 Query: 243 K--KHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIV 300 K+A L A + + + +++ K E + +K+I D G + ++ Sbjct: 238 AGGNVKIACLDLNLQKARMAMGVQINIDDPEQLEQIRKREAGIVLERVKKIIDAGAQVVL 297 Query: 301 AGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEE------LGL 354 G+ +L L I+ ++ K +LRR+ R GAT + + EE LGL Sbjct: 298 TTKGIDDLCLKEFVEAKIMGVRRCKKEDLRRIARATGATLVSSMSNLEGEETFESSYLGL 357 Query: 355 VETVKTMEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKP 414 + V + D + K S S+IILRGA +LD++ER++ D ++ VK ++ Sbjct: 358 CDEVVQAKFSDDECILIKGTSKHSS--SSIILRGANDYSLDEMERSLHDSLSVVKRTLE- 414 Query: 415 SGGKLLPGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEV 474 G ++PG G E L + + QLAI +FA A ++P+TLA A D +E+ Sbjct: 415 -SGNVVPGGGCVEAALNIYLDNFATTVGSREQLAIAEFAAALLIIPKTLAVNAAKDSSEL 473 Query: 475 LPNLYAAHNVTE--PGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVAT 532 + L + H ++ Y+ +D + + D + + +K ++ A Sbjct: 474 VAKLRSYHAASQMAKPEDVKRRSYRNYGLDLIRGK-IVDEIHAGVLEPTISKVKSLKSAL 532 Query: 533 EAATTVLSIDQIIMAKKAGGPRAP 556 EA +L ID +I P Sbjct: 533 EACVAILRIDTMITVDPEPPKEDP 556 >5GW5-z nrPDB Length = 546 Score = 489 bits (1260), Expect = e-138, Method: Composition-based stats. Identities = 143/571 (25%), Positives = 254/571 (44%), Gaps = 39/571 (6%) Query: 1 MSLRLPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLG 60 MSL+L NP A + D + ++ + L + T++GP G K++V+ G Sbjct: 1 MSLQL-LNPKAESLR--------RDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAG 51 Query: 61 KIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISM 120 I +T D +L E+ I P ++ A Q GDGT V+ L GELL + + I Sbjct: 52 NIKLTKDGKVLLTEMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQE 111 Query: 121 GLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGS-EDILS 179 G+ I G+ +ARK ++K LDE + + ND+ LL++ + + +K ++L+ Sbjct: 112 GVHPRIITDGFEIARKESMKFLDEFKISKTNLSNDREFLLQVARSSLLTKVDADLTEVLT 171 Query: 180 ELVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSL 239 +V++AV V + ++ + ++++ S ++T IKG+V + H Sbjct: 172 PIVTDAVLSVYDA-----QADNLDLHMVEIMQMQHLSPKDTTFIKGLVLD-HGGRHPDMP 225 Query: 240 SEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVE-- 297 + K V + L+ TE +A + + E K +DA +K+I D+ E Sbjct: 226 TRVKNAYVLILNVSLEYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVC 285 Query: 298 --------CIVAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTP 349 I+ G+ ++L ++ IL L+ + + RL V G + +P Sbjct: 286 GMDPDKGFVIINQKGIDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSP 345 Query: 350 EELGLVETVKTMEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVK 409 + LG V IG ++ T + ++ TI+++G+T L + A+ DG+ AV Sbjct: 346 QILGFSGLVYQETIGEEKFTYVT--ENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVA 403 Query: 410 GLMKPSGGKLLPGAGATEIELISRITKY---GERTPGLLQLAIKQFAVAFEVVPRTLAET 466 ++K ++PGAGA I L + G + I+ FA A V+P+TL + Sbjct: 404 NVLKDKN--IIPGAGAFYIALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKN 461 Query: 467 AGLDVNEVLPNLYAAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKF 526 +G D +VL + + + Y GVD++ D E I+D + Sbjct: 462 SGFDPLDVLA---MVEDELDDAQDSDETRYVGVDLNIGDS---CDPTIEGIWDSYRVLRN 515 Query: 527 AINVATEAATTVLSIDQIIMAKKAGGPRAPQ 557 AI AT A+ +L D+++ A ++ PQ Sbjct: 516 AITGATGIASNLLLCDELLRAGRSTLKETPQ 546 >4B2T-Z nrPDB Length = 531 Score = 483 bits (1243), Expect = e-137, Method: Composition-based stats. Identities = 136/563 (24%), Positives = 258/563 (45%), Gaps = 43/563 (7%) Query: 1 MSLRLPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLG 60 M+ NP A + + A + +I+A R L + T++GP G K++V+ G Sbjct: 1 MAAVKTLNPKAEV--------ARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAG 52 Query: 61 KIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISM 120 I +T D +L E+ I HP ++ Q GDGT +++ GELL ++ IS Sbjct: 53 DIKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISE 112 Query: 121 GLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGS-EDILS 179 GL I +G+ A++ L+ L+++ V + + D+ L+ + + + +K + D+L+ Sbjct: 113 GLHPRIITEGFEAAKEKALQFLEQVKV---SKEMDRETLIDVARTSLRTKVHAELADVLT 169 Query: 180 ELVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSL 239 E V +++ + + ++ + ++++ S +++++I+G+V + H Sbjct: 170 EAVVDSILAIKKQDEP------IDLFMVEIMEMKHKSETDTSLIRGLVLD-HGARHPDMK 222 Query: 240 SEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVE-- 297 + + L+ TE +A+E K E K I+ +K+I ++ + Sbjct: 223 KRVEDAYILTCNVSLEYEKTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIIELKKKVC 282 Query: 298 -------CIVAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPE 350 ++ G+ +L L + GI+ L+ + + RL CG L L P+ Sbjct: 283 GDSDKGFVVINQKGIDPFSLDALAKEGIIALRRAKRRNMERLTLACGGIALNSLDDLNPD 342 Query: 351 ELGLVETVKTMEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKG 410 LG V +G ++ T E+ R+ T++++G ++ L I+ AI DG+ AVK Sbjct: 343 CLGHAGLVYEYTLGEEKFTFI--EKCNNPRSVTLLIKGPNKHTLTQIKDAIRDGLRAVKN 400 Query: 411 LMKPSGGKLLPGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLD 470 + G ++PGAGA E+ + + KY G QL ++ FA A ++P+ LA+ +G D Sbjct: 401 AIDD--GCVVPGAGAVEVAMAEALVKYKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFD 458 Query: 471 VNEVLPNLYAAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINV 530 + E L + A H+ + GVD++ E I+D KK ++ Sbjct: 459 LQETLVKVQAEHSES--------GQLVGVDLNTGEPMVAA---EAGIWDNYCVKKQLLHS 507 Query: 531 ATEAATTVLSIDQIIMAKKAGGP 553 T AT +L +D+I+ A + Sbjct: 508 CTVIATNILLVDEIMRAGMSSLK 530 >4B2T-B nrPDB Length = 535 Score = 478 bits (1229), Expect = e-135, Method: Composition-based stats. Identities = 140/559 (25%), Positives = 264/559 (47%), Gaps = 35/559 (6%) Query: 3 LRLPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNH--LG 60 L P +FK G + ++ I AI + + +++GP G +KI+++ Sbjct: 2 ASLSLAP-VNIFKAGADEERAETARLSSFIGAI-AIGDLVKSTLGPKGMDKILLSSGRDA 59 Query: 61 KIIITNDAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISM 120 +++TND AT+L+ + + +PA KVLV + Q ++GDGT V +LA ELL +E LI+ Sbjct: 60 SLMVTNDGATILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAK 119 Query: 121 GLSAVEIIQGYNMARKFTLKELDEMVVGEITDK-NDKNELLKMIKPVISSKKYG-SEDIL 178 + II G+ A K + L V +D+ + +L+ + +SSK +D Sbjct: 120 KIHPQTIIAGWREATKAARQALLNSAVDHGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHF 179 Query: 179 SELVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKS 238 ++L EAV + N+++I V+K +GGSL++S + +G + +++ V Sbjct: 180 TKLAVEAVLRLKGSG---------NLEAIHVIKKLGGSLADSYLDEGFLLDKKIG--VNQ 228 Query: 239 LSEDKKHKVAVFTCPLDIANTETKGT-VLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVE 297 + K+ + +D + G+ V + + ++ + E++++ ++ I G+ Sbjct: 229 PKRIENAKILIANTGMDTDKIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGIN 288 Query: 298 CIVAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVET 357 C + + G++ ++ + RL V G P +LG + Sbjct: 289 CFINRQLIYNYPEQLFGAAGVMAIEHADFVGVERLALVTGGEIASTFDHPELVKLGSCKL 348 Query: 358 VKTMEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGG 417 ++ + IG D++ F + TI+LRGATQ LD+ ER++ D + + +K S Sbjct: 349 IEEVMIGEDKLIHFSGVA--LGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDS-- 404 Query: 418 KLLPGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPN 477 + + G G +E+ + +T+ RTPG +A++ +A A ++P +A+ AG D +++ Sbjct: 405 RTVYGGGCSEMLMAHAVTQLASRTPGKEAVAMESYAKALRMLPTIIADNAGYDSADLVAQ 464 Query: 478 LYAAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATT 537 L AAH+ + A G+D+ + + D+ I + K+ + A EAA Sbjct: 465 LRAAHSEGKTTA--------GLDMKEGT---IGDMSVLGITESFQVKRQVLLSAAEAAEV 513 Query: 538 VLSIDQIIMAKKAGGPRAP 556 +L +D II K A R P Sbjct: 514 ILRVDNII--KAAPRKRVP 530 >4V8R-AB nrPDB Length = 527 Score = 470 bits (1210), Expect = e-133, Method: Composition-based stats. Identities = 127/550 (23%), Positives = 251/550 (45%), Gaps = 32/550 (5%) Query: 10 NAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVN-HLGKIIITNDA 68 + +F + ++ + AI + + +++GP G +K++ + ++TND Sbjct: 2 SVQIFGDQVTEERAENARLSAFVGAI-AVGDLVKSTLGPKGMDKLLQSASSNTCMVTNDG 60 Query: 69 ATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISM-GLSAVEI 127 AT+L+ + + +PA KVLV ++ Q ++GDGT V +L+ ELL +EKLI + I Sbjct: 61 ATILKSIPLDNPAAKVLVNISKVQDDEVGDGTTSVTVLSAELLREAEKLIDQSKIHPQTI 120 Query: 128 IQGYNMARKFTLKELDEMVVGEITDKN-DKNELLKMIKPVISSKKYGSE-DILSELVSEA 185 I+GY +A L L + V DK + +L+ + K +SSK + D +EL + A Sbjct: 121 IEGYRLASAAALDALTKAAVDNSHDKTMFREDLIHIAKTTLSSKILSQDKDHFAELATNA 180 Query: 186 VSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKH 245 + + N++ I+++KI+GG LS+S + +G + ++ + Sbjct: 181 ILRL---------KGSTNLEHIQIIKILGGKLSDSFLDEGFILAKKFGN--NQPKRIENA 229 Query: 246 KVAVFTCPLDIANTETKG-TVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAG 304 K+ + LD + G + + ++ K E +++ + +I+ G+ + Sbjct: 230 KILIANTTLDTDKVKIFGTKFKVDSTAKLAQLEKAEREKMKNKIAKISKFGINTFINRQL 289 Query: 305 VGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIG 364 + + GI ++ + RL V G + P+ +LG + ++ + +G Sbjct: 290 IYDYPEQLFTDLGINSIEHADFEGVERLALVTGGEVVSTFDEPSKCKLGECDVIEEIMLG 349 Query: 365 GDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAG 424 F + TI+LRGAT LD+ ER++ D ++ + K + + + G G Sbjct: 350 EQPFLKFSG--CKAGEACTIVLRGATDQTLDEAERSLHDALSVLSQTTKET--RTVLGGG 405 Query: 425 ATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNV 484 E+ + + + G LA++ FA A +P LA+ AG D +E++ L ++ Sbjct: 406 CAEMVMSKAVDTEAQNIDGKKSLAVEAFARALRQLPTILADNAGFDSSELVSKLRSS--- 462 Query: 485 TEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQI 544 + G+D++ + + D+R+ I + K+ ++ A+EAA +L +D I Sbjct: 463 -----IYNGISTSGLDLNNGT---IADMRQLGIVESYKLKRAVVSSASEAAEVLLRVDNI 514 Query: 545 IMAKKAGGPR 554 I A+ R Sbjct: 515 IRARPRTANR 524 >5X9V-A nrPDB Length = 521 Score = 389 bits (1000), Expect = e-108, Method: Composition-based stats. Identities = 124/541 (22%), Positives = 234/541 (43%), Gaps = 46/541 (8%) Query: 15 KQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRE 74 + + + AA++ L Q+ S+GP G + ++V+ G++++TND T+L Sbjct: 4 ENQTQEIEERYQALFSNAAAVKALTQVVANSLGPKGLDAMLVDRFGEVVVTNDGVTILTL 63 Query: 75 LDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNMA 134 +D HPA +++V Q+ ++GDGT +LAG L++ I G+ +++ G N A Sbjct: 64 MDAQHPAARMVVNMARAQEREVGDGTTTAAVLAGALVSEGVNQILKGVPVSKVLAGMNRA 123 Query: 135 RKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGSEDILSELVSEAVSHVLPVAQ 194 L + + + + +D+ + ++K G D E V+ + + + Sbjct: 124 LNHALFLIRKNAIKVGSITDDR--------LLAAAKIAGRGD---ERVAAILRDAAAMLE 172 Query: 195 QAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFTCPL 254 + P F + + + K+ +++T+I G+V N+ P S K +V + Sbjct: 173 DKLQDPGFKLADLVLAKVG----ADTTLIPGVVINKSPLWEEGSQ---KLQEVRLLVLDD 225 Query: 255 DIANTETKGTVLLHNA--QEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGELALHY 312 + E + L A ++ L +K +K++ ++GV+ I+ G+ ++A + Sbjct: 226 GLYPEEVEEEALASEAGFEQYLK----NQKIFQENLKKLKELGVKLILLTRGISDIAEEF 281 Query: 313 LNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEE-----LGLVETVKTMEIGGDR 367 I+V+ ++ EL+R+ GA R P E LG T R Sbjct: 282 CYENEIMVITRITQKELKRVLEFTGARAAKRTSLNKPVEELQKMLGYARTC----FYDSR 337 Query: 368 VTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATE 427 + E G T+T+++ AT +D+ ER D + + +LPG GA Sbjct: 338 LDFTIIEGGAGKATATVLIGAATDEVVDEQERIAKDAAGSFAAAYRSG---VLPGGGAFF 394 Query: 428 IELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEP 487 + L + R PG+ + F+ A +V R +AE AG + E L +L Sbjct: 395 LYLSREVESLKNRLPGMESYGVMAFSEALKVPFRVMAENAGFNGLEKLGDLMTLQ----- 449 Query: 488 GAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQIIMA 547 V+ ++ G+D E+ E + D+ + D A+ A+E A ++L I+ II Sbjct: 450 --VQKNNYALGLDF--ETGEFI-DMIAGGVVDPAEVVYQAVKNASEVAISLLKINTIIKM 504 Query: 548 K 548 K Sbjct: 505 K 505 >4V8R-AG nrPDB Length = 590 Score = 355 bits (910), Expect = 4e-98, Method: Composition-based stats. Identities = 102/378 (26%), Positives = 180/378 (47%), Gaps = 10/378 (2%) Query: 8 NPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITND 67 + QI +I A + + + T +GP K++++ +G +++TND Sbjct: 2 QAPVVFMNASQERTTGRQAQI-SNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND 60 Query: 68 AATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNV-SEKLISMGLSAVE 126 +LRE+D+ HPA K ++ + Q ++GDGT V+ILAGE+L + LI + V Sbjct: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 Query: 127 IIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGS-EDILSELVSEA 185 IIQ A L+ + + V + D + + K+I+ I +K + + EL +A Sbjct: 121 IIQALKKALTDALEVIKQ--VSKPVDVENDAAMKKLIQASIGTKYVIHWSEKMCELALDA 178 Query: 186 VSHVL-PVAQQAGEIPYFNVD---SIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSE 241 V V + Q P F +D +RV KI GG + +S V+KG++ N++ H K Sbjct: 179 VKTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVV-HPKMSRH 237 Query: 242 DKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVA 301 + +V + CPL+ E++ + + ++ + EE+Q+ M ++I + ++ Sbjct: 238 IENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTLVIT 297 Query: 302 GAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTM 361 GV +LA HYL + G VL+ K + R+ RV GAT + R+ ++G + + Sbjct: 298 EKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGLFKV 357 Query: 362 EIGGDRVTVFKQEQGEIS 379 E+ GD F E Sbjct: 358 EMIGDEYFSFLDNCKEPG 375 Score = 174 bits (442), Expect = 6e-44, Method: Composition-based stats. Identities = 46/171 (26%), Positives = 86/171 (50%), Gaps = 13/171 (7%) Query: 380 RTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATEIELISRITKYGE 439 + TI+LRG +++ L++I+R + D +A + +M L PG GATE+ + ++ + + Sbjct: 431 KACTIMLRGGSKDILNEIDRNLQDAMAVARNVM--LSPSLSPGGGATEMAVSVKLAEKAK 488 Query: 440 RTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPGAVKTDHLYKGV 499 + G+ Q + A A E +PRTL + AG D +L L A H + G+ Sbjct: 489 QLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQG--------NFTTGI 540 Query: 500 DIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQIIMAKKA 550 D G+ + + D+ I++ K+ ++ A E+A +L +D I+ + Sbjct: 541 D--GDKGK-IVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVSGVRK 588 >1GN1-A nrPDB Length = 178 Score = 186 bits (473), Expect = 2e-47, Method: Composition-based stats. Identities = 36/175 (20%), Positives = 83/175 (47%), Gaps = 4/175 (2%) Query: 217 LSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDF 276 + +S V++G++ N++ H + K ++ + L+ E++ + + ++ Sbjct: 1 MEDSCVLRGVMINKDVT-HPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRI 59 Query: 277 SKGEEKQIDAMMKEIADMGVECIVAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVC 336 + EE+ I + ++I + + ++ G+ +LA HYL R + ++ K + R+ R C Sbjct: 60 LQMEEEYIHQLCEDIIQLKPDVVITEKGISDLAQHYLMRANVTAIRRVRKTDNNRIARAC 119 Query: 337 GATPLPRLGAPTPEELGL-VETVKTMEIGGDRVTVFKQEQGEISRTSTIILRGAT 390 GA + R +++G ++ +IG + T + + TI+LRGA+ Sbjct: 120 GARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITD--CKDPKACTILLRGAS 172 >1E0R-B nrPDB Length = 159 Score = 178 bits (451), Expect = 6e-45, Method: Composition-based stats. Identities = 35/154 (22%), Positives = 75/154 (48%), Gaps = 1/154 (0%) Query: 223 IKGMVFNREPEGHVKSLSEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEK 282 + G++ ++E + H K K+A+ PL+I E + + + + F EE Sbjct: 1 MNGIIVDKE-KVHPGMPDVVKDAKIALLDAPLEIKKPEFDTNLRIEDPSMIQKFLAQEEN 59 Query: 283 QIDAMMKEIADMGVECIVAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLP 342 + M+ +I +G ++ G+ ++A HYL+R GI ++ K ++ +L + GA+ + Sbjct: 60 MLREMVDKIKSVGANVVITQKGIDDMAQHYLSRAGIYAVRRVKKSDMDKLAKATGASIVS 119 Query: 343 RLGAPTPEELGLVETVKTMEIGGDRVTVFKQEQG 376 + + +LG E V+ +++G D +T + Sbjct: 120 TIDEISSSDLGTAERVEQVKVGEDYMTFVTGSKN 153 >1ASS-A nrPDB Length = 159 Score = 176 bits (445), Expect = 3e-44, Method: Composition-based stats. Identities = 43/152 (28%), Positives = 75/152 (49%), Gaps = 1/152 (0%) Query: 225 GMVFNREPEGHVKSLSEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQI 284 G+V ++E + H K K K+A+ L+I TE + V + + ++ DF E Sbjct: 3 GIVIDKE-KVHSKMPDVVKNAKIALIDSALEIKKTEIEAKVQISDPSKIQDFLNQETNTF 61 Query: 285 DAMMKEIADMGVECIVAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRL 344 M+++I G ++ G+ ++A HYL + GI ++ K ++ +L + GA + L Sbjct: 62 KQMVEKIKKSGANVVLCQKGIDDVAQHYLAKEGIYAVRRVKKSDMEKLAKATGAKIVTDL 121 Query: 345 GAPTPEELGLVETVKTMEIGGDRVTVFKQEQG 376 TP LG ETV+ +IG DR+T + Sbjct: 122 DDLTPSVLGEAETVEERKIGDDRMTFVMGCKN 153 >4V4O-A nrPDB Length = 543 Score = 176 bits (445), Expect = 3e-44, Method: Composition-based stats. Identities = 89/585 (15%), Positives = 194/585 (33%), Gaps = 113/585 (19%) Query: 34 AIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVHP----AVKVLVMAT 89 + + ++GP GRN ++ G IT D T+ +E+++ ++L Sbjct: 18 GVNAVANAVKVTLGPRGRNVVLEKKFGSPTITKDGVTVAKEVELEDHLENIGAQLLKEVA 77 Query: 90 EQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNMARKFTLKELDEMVVGE 149 + GDGT +LA ++ K ++ G + + + +G A + ++++ + + Sbjct: 78 SKTNDVAGDGTTTATVLAQAIVREGLKNVAAGANPLALKRGIEKAVEAAVEKIKALAIPV 137 Query: 150 ITDKNDKNELLKMIKPVISSKKYGSEDILSELVSEAVSHVLPVAQQAGEIPYFNVDSIRV 209 D+ + ++ ++ + +L+++A+ V G+ V+ + Sbjct: 138 ----EDRKAIEEVATIS------ANDPEVGKLIADAMEKV-------GKEGIITVEESKS 180 Query: 210 VKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFTCPLDIANTETKGTVLLHN 269 ++ + KG + + + + + + N Sbjct: 181 LETELKFVEGYQFDKGYISPYFVTNPETMEAVLEDAFILIV-------------EKKVSN 227 Query: 270 AQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGELALHYLNRYG------ILVLKV 323 +E+L +++A G ++ V AL L + +K Sbjct: 228 VRELLPIL-----------EQVAQTGKPLLIIAEDVEGEALATLVVNKLRGTLSVAAVKA 276 Query: 324 PSKFE-----LRRLCRVCGATPLP-----RLGAPTPEELGLVETVKTMEIGGDRVTVFKQ 373 P + L+ + V G T + +L T LG E V I D T+ Sbjct: 277 PGFGDRRKEMLKDIAAVTGGTVISEELGFKLENATLSMLGRAERV---RITKDETTIVGG 333 Query: 374 EQGEI---------------------------------SRTSTIILRGATQNNLDDIERA 400 + + + I + AT+ L + + Sbjct: 334 KGKKEDIEARINGIKKELETTDSEYAREKLQERLAKLAGGVAVIRVGAATETELKEKKHR 393 Query: 401 IDDGVAAVKGLMKPSGGKLLPGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVP 460 +D + A + ++ ++PG G T + IS + + ++ G K A E Sbjct: 394 FEDALNATRAAVEEG---IVPGGGVTLLRAISAVEELIKKLEGDEATGAKIVRRALEEPA 450 Query: 461 RTLAETAGLDVNEVLPNLYAAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDM 520 R +AE AG + + ++ + A + + E V D+ E I D Sbjct: 451 RQIAENAGYEGSVIVQQILAETKNPR------------YGFNAATGEFV-DMVEAGIVDP 497 Query: 521 LATKKFAINVATEAATTVLSIDQIIMAKKAGGPRAPQGPRPGNWD 565 + A+ A +L+ + ++ K P G+ D Sbjct: 498 AKVTRSALQNAASIGALILTTEAVVAEKPEKKESTPASAGAGDMD 542 >5CDI-A nrPDB Length = 552 Score = 160 bits (404), Expect = 2e-39, Method: Composition-based stats. Identities = 99/569 (17%), Positives = 201/569 (35%), Gaps = 64/569 (11%) Query: 21 YSNADGQIIKSIAA-IRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVH 79 + N D Q +K + A + +L + ++GP GRN ++ + G I ND T+ RE+++ Sbjct: 6 HFNKDMQALKRMQAGVDKLATVVGVTIGPKGRNVVLESKFGAPKIVNDGVTIAREVELSD 65 Query: 80 P----AVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNMAR 135 P ++ A + GDGT +L+ + K++S G + V++++G Sbjct: 66 PVENIGATLVRQAAARTNDTAGDGTTTATVLSAAFIAEGMKIVSAGTNPVQLVRGMEKTV 125 Query: 136 KFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGSEDILSELVSEAVSHVLPVAQQ 195 + +KEL +M TDK+ N V G+ DI S L+S+A++ V Sbjct: 126 QELVKELRKMSSVVQTDKDLAN--------VACVSAGGNTDIGS-LISDAMAKVGRTGVV 176 Query: 196 AGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFTCPLD 255 E D + V+ M +G + + E + K+ + + Sbjct: 177 TMEEGKTAEDQLVFVEGM-------QFERGYTSPYFVTDPERMICEYENCKILLVDKKIS 229 Query: 256 IAN---TETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGELALHY 312 A T + + + ++ +E ++ ++ + G GE Y Sbjct: 230 TARDIITILESAIRGNYPLLIMAEEVEQEALATLVVNKLRGTLKVVAIKAPGFGERRSSY 289 Query: 313 LNRYGIL----VLKVPSKFELRRLCRVCGATPL---------------PRLGAPTPEELG 353 L IL V++ L + T Sbjct: 290 LEDIAILTGGTVVRDEMGVSLEQATDAVLGTAAKITITKERTTVVGDGSTAADVAARVKQ 349 Query: 354 LVETVKTMEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMK 413 + + +R + ++ + I + T+ L + + ++D + A + ++ Sbjct: 350 IRNLQMQTDQDYEREKLQERIARLSGGVAIIQVGAQTETELKEKKLRVEDALNATRAAVE 409 Query: 414 PSGGKLLPGAGATEIELISRITKYGERTPGLL-QLAIKQFAVAFEVVPRTLAETAGLDVN 472 ++PG G T + L ++ R Q+ A + +A+ AG++ + Sbjct: 410 EG---VVPGGGCTLLRLSEKVDVIKRRMTDPEQQMGADIIKRALCYPIKLIAQNAGVNGS 466 Query: 473 EVLPNLYAAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVAT 532 V+ + D + G + +S E ++ E I D + ++ A Sbjct: 467 VVMNEVM----------KNLDRPHYGYNAATDSFE---NLMETGIIDPSKVVRCSMENAV 513 Query: 533 EAATTVLSIDQIIMAKKAGGPRAPQGPRP 561 A T L D ++ G +P Sbjct: 514 SVAKTFLLADVVVT----ELKEIEAGAKP 538 >1IOK-A nrPDB Length = 545 Score = 145 bits (367), Expect = 3e-35, Method: Composition-based stats. Identities = 78/548 (14%), Positives = 181/548 (33%), Gaps = 60/548 (10%) Query: 34 AIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVHP----AVKVLVMAT 89 + L ++GP GRN +I G IT D ++ +E+++ +++ Sbjct: 19 GVNILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEIELSDKFENMGAQMVREVA 78 Query: 90 EQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNMARKFTLKELDEMVVGE 149 + + GDGT +LA ++ K ++ G++ +++ +G ++A ++ + Sbjct: 79 SRTNDEAGDGTTTATVLAQAIVREGLKAVAAGMNPMDLKRGIDVATAKVVEAIKSAARPV 138 Query: 150 ITDKNDKNELLKMIKPVISSKKYGSEDILSELVSEAVSHVLPVAQQAGEIPYFNVDSIRV 209 ND +E+ ++ + E + + ++EA+ V G V+ + Sbjct: 139 ----NDSSEVAQVGTISANG-----ESFIGQQIAEAMQRV-------GNEGVITVEENKG 182 Query: 210 VKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFT---CPLDIANTETKGTVL 266 ++ + +G + K ++E + + + L + + Sbjct: 183 METEVEVVEGMQFDRGYLSPYFVTNADKMIAELEDAYILLHEKKLSSLQPMVPLLESVIQ 242 Query: 267 LHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGELALHYLNRYGILVLKVPSK 326 ++ E ++ ++ V G G+ L IL Sbjct: 243 SQKPLLIVAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLQDIAILTGGQVIS 302 Query: 327 FELR-RLCRVC-----GATPLPRLGAPTPEELGLVE-------------TVKTMEIGGDR 367 +L +L V A + T G E ++ DR Sbjct: 303 EDLGMKLENVTIDMLGRAKKVSINKDNTTIVDGAGEKAEIEARVSQIRQQIEETTSDYDR 362 Query: 368 VTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATE 427 + ++ + I + G T+ + + + +DD + A + ++ ++ G G Sbjct: 363 EKLQERVAKLAGGVAVIRVGGMTEIEVKERKDRVDDALNATRAAVQEG---IVVGGGVAL 419 Query: 428 IELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEP 487 ++ + I A E R +AE AG+D V + + + Sbjct: 420 VQGAKVLEGLS-GANSDQDAGIAIIRRALEAPMRQIAENAGVDGAVVAGKVRESSDKAFG 478 Query: 488 GAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSIDQIIMA 547 +T+ D+ + + D + A+ A A +++ + +I Sbjct: 479 FNAQTEEY--------------GDMFKFGVIDPAKVVRTALEDAASVAGLLITTEAMIAE 524 Query: 548 KKAGGPRA 555 K A Sbjct: 525 KPEPKAPA 532 >4PJ1-A nrPDB Length = 558 Score = 137 bits (345), Expect = 1e-32, Method: Composition-based stats. Identities = 88/554 (15%), Positives = 201/554 (36%), Gaps = 49/554 (8%) Query: 5 LPQNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIII 64 +P N + AD + + + + L +MGP GR II G + Sbjct: 17 IPTTENLYFQGSAKDVKFGADARALM-LQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKV 75 Query: 65 TNDAATMLRELDIVHP----AVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISM 120 T D T+ + +D+ K++ + GDGT +LA + + IS Sbjct: 76 TKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISK 135 Query: 121 GLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGSEDILSE 180 G + VEI +G +A + EL + T E+ ++ + + + Sbjct: 136 GANPVEIRRGVMLAVDAVIAELKKQSKPVTTP----EEIAQVATISANG-----DKEIGN 186 Query: 181 LVSEAVSHVLP---VAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVK 237 ++S+A+ V + + G+ ++ I +K G +S + E + Sbjct: 187 IISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYV 246 Query: 238 SLSEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVE 297 LSE K + L+IAN K V++ + S ++ ++ +A Sbjct: 247 LLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPG 306 Query: 298 CIVAGAG-VGELAL----HYLNRYGILV-LKVPSKFELRRLCRVC----GATPLPRLGAP 347 + ++A+ G+ + L+ +L ++ +V A L G Sbjct: 307 FGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGKVIVTKDDAMLLKGKGDK 366 Query: 348 TPEELGLVETVKTMEIGGDRVTVFKQEQ--GEISRTSTII-LRGATQNNLDDIERAIDDG 404 E + E ++ +++ K + ++S ++ + G + +++ + + D Sbjct: 367 AQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDA 426 Query: 405 VAAVKGLMKPSGGKLLPGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLA 464 + A + ++ ++ G G + I + ++ I+ ++ T+A Sbjct: 427 LNATRAAVEEG---IVLGGGCALLRCIPALDSLTPANED-QKIGIEIIKRTLKIPAMTIA 482 Query: 465 ETAGLDVNEVLPNLYAAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATK 524 + AG++ + ++ + + + A+ D + ++ E+ I D Sbjct: 483 KNAGVEGSLIVEKIMQSSSEVGYDAMAGDFV---------------NMVEKGIIDPTKVV 527 Query: 525 KFAINVATEAATTV 538 + A+ A A+ + Sbjct: 528 RTALLDAAGVASLL 541 >4AAR-A nrPDB Length = 548 Score = 135 bits (340), Expect = 5e-32, Method: Composition-based stats. Identities = 85/572 (14%), Positives = 186/572 (32%), Gaps = 110/572 (19%) Query: 18 YNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDI 77 + D ++ + + L ++GP GRN ++ G IT D ++ RE+++ Sbjct: 4 KDVKFGNDARVKM-LRGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIEL 62 Query: 78 VHP----AVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNM 133 +++ + GDGT +LA ++ K ++ G++ +++ +G + Sbjct: 63 EDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIITEGLKAVAAGMNPMDLKRGIDK 122 Query: 134 ARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGSEDILSELVSEAVSHVLPVA 193 A ++EL + V K + + S++ + +L++EA+ V Sbjct: 123 AVTAAVEELKALSVPCSDSK---------AIAQVGTISANSDETVGKLIAEAMDKVGKEG 173 Query: 194 QQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFTCP 253 E G V++GM F+R Sbjct: 174 VITVEDGT-------------GLQDELDVVEGMQFDRGYLSPYFINKP------------ 208 Query: 254 LDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAGVGELALHYL 313 + E + +L +++ + + + +++ +A G ++ V AL L Sbjct: 209 -ETGAVELESPFILLADKKISNIRE-----MLPVLEAVAKAGKPLLIIAEDVEGEALATL 262 Query: 314 NRY------GILVLKVPSKFELRR-----LCRVCGATPLP-----RLGAPTPEELGLVET 357 + +K P + R+ + + G T + L T E+LG + Sbjct: 263 VVNTMRGIVKVAAVKAPGFGDRRKAMLQDIATLTGGTVISEEIGMELEKATLEDLGQAKR 322 Query: 358 V------------------------------KTMEIGGDRVTVFKQEQGEISRTSTIILR 387 V + DR + ++ + I + Sbjct: 323 VVINKDTTTIIDGVGEEAAIQGRVAQIRQQIEEATSDYDREKLQERVAKLAGGVAVIKVG 382 Query: 388 GATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATEIELISRITKYGERTPGLLQL 447 AT+ + + + ++ + A + ++ ++ G G I + S++ + Sbjct: 383 AATEVEMKEKKARVEAALHATRAAVEEG---VVAGGGVALIRVASKLADL-RGQNEDQNV 438 Query: 448 AIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPGAVKTDHLYKGVDIDGESDE 507 IK A E R + G + + V VK G + E Sbjct: 439 GIKVALRAMEAPLRQIVLNCGEEPSVV------------ANTVKGGDGNYGYNAATEEYG 486 Query: 508 GVKDIREENIYDMLATKKFAINVATEAATTVL 539 + D+ I D + A+ A A ++ Sbjct: 487 NMIDM---GILDPTKVTRSALQYAASVAGLMI 515 >5DA8-A nrPDB Length = 545 Score = 135 bits (339), Expect = 7e-32, Method: Composition-based stats. Identities = 73/541 (13%), Positives = 175/541 (32%), Gaps = 78/541 (14%) Query: 34 AIRELHQMCLTSMGPCGRNKIIVNHLGKIIITNDAATMLRELDIVHP----AVKVLVMAT 89 + +L ++GP GRN +I G T D T+ +E+++V P +++ Sbjct: 19 GVDKLANAVKVTLGPAGRNVLIDKKFGAPTSTKDGVTVAKEIELVDPVENMGAQMVREVA 78 Query: 90 EQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVEIIQGYNMARKFTLKELDEMVVGE 149 + GDGT +LA + K ++ G +++ +G + A K + EL + Sbjct: 79 SKTSDVAGDGTTTATVLAQAIYREGLKNVTAGARPIDLKRGIDRAVKEVVAELRNISRSI 138 Query: 150 ITDKNDKNELLKMIKPVISSKKYGSEDILSELVSEAVSHVLPVAQQAGEIPYFNVDSIRV 209 K + + ++ + EL++EA+ V G+ V+ + Sbjct: 139 SGKKEIAQ---------VGTISANNDPEIGELIAEAMDKV-------GKDGVITVEEAKG 182 Query: 210 VKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFTCPLDIANT---------- 259 ++ + +G + +E + + + + Sbjct: 183 METELKVVEGMQFDRGYLSPYFVTNSETMEAELDEALILIHDKKISNMKELLPILEKAAQ 242 Query: 260 --------------ETKGTVLLHNAQEMLDFSKGEEKQI----DAMMKEIADMGVECIVA 301 E T++++ + L + + AM+++IA + +++ Sbjct: 243 SGRPLLIIAEDIEGEALATLVVNKLRGTLKVAAVKAPGFGDRRKAMLEDIAILTGGTVIS 302 Query: 302 GAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGA--TPLPRLGAPTPEELGLVETVK 359 +L + G ++ + + G R+ + ++ Sbjct: 303 EEKGYKLENATMAYLG-QAARITIDKDNTTIVEGKGKQEEIKARINEIKGQ-------IE 354 Query: 360 TMEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKL 419 D + ++ + + + +T+ + + + ++D + A + ++ + Sbjct: 355 KSTSDYDTEKLQERLAKLSGGVAVLKIGASTEVEMKEKKARVEDALHATRAAVQEG---I 411 Query: 420 LPGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAG-LDVNEVLPNL 478 + G G I + K + I+ A E R + G D VL + Sbjct: 412 VVGGGVALIRAAKGLAK-AVADNEDQKTGIEIIRRALEEPLRQIVANTGTTDGAVVLEKV 470 Query: 479 YAAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTV 538 A A E +++ E + D + A+ A A+ + Sbjct: 471 KNAEGDYGFNA---------------RTEQYENLIEAGVVDPTKVTRSALENAASVASIL 515 Query: 539 L 539 L Sbjct: 516 L 516 >1SJP-A nrPDB Length = 504 Score = 126 bits (316), Expect = 3e-29, Method: Composition-based stats. Identities = 70/522 (13%), Positives = 164/522 (31%), Gaps = 63/522 (12%) Query: 60 GKIIITNDAATMLRELDIVHP----AVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSE 115 G ITND ++ +E+++ P +++ ++ GDGT +LA L+ Sbjct: 2 GAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGL 61 Query: 116 KLISMGLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYGSE 175 + ++ G + + + +G A + + L + + ++ S + Sbjct: 62 RNVAAGANPLGLKRGIEKAVEKVTETLLKGA-------KEVETKEQIAATAAIS---AGD 111 Query: 176 DILSELVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGH 235 + +L++EA+ V G V+ + KG + Sbjct: 112 QSIGDLIAEAMDKV-------GNEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDP 164 Query: 236 VKSLSEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGE---EKQIDAMMKEIA 292 + + + + + + + + A + L + E ++ +I Sbjct: 165 ERQEAVLEDPYILLVSSKVSTVKDLLPLLEKVIGAGKPLLIIAEDVEGEALSTLVVNKIR 224 Query: 293 DMGVECIVAGAGVGELALHYLNRYGILVLKVP---------SKFELRRLCRV-------- 335 V G G+ L IL +L L + Sbjct: 225 GTFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISEEVGLTLENADLSLLGKARKVVVTKD 284 Query: 336 --CGATPLPRLGAPTPEELGLVETVKTMEIGGDRVTVFKQEQGEISRTSTIILRGATQNN 393 A + + ++ + DR + ++ + I AT+ Sbjct: 285 ETTIVEGAGDTDAIAGRVAQIRQEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVE 344 Query: 394 LDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATEIELISRITKYGERTPGLLQLAIKQFA 453 L + + I+D V K ++ ++ G G T ++ + + + G Sbjct: 345 LKERKHRIEDAVRNAKAAVEEG---IVAGGGVTLLQAAPTLDEL--KLEGDEATGANIVK 399 Query: 454 VAFEVVPRTLAETAGLDVNEVLPNLYAAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIR 513 VA E + +A +GL+ V + +L G ++ ++ +D+ Sbjct: 400 VALEAPLKQIAFNSGLEPGVVAEKVR--------------NLPAGHGLNAQTGVY-EDLL 444 Query: 514 EENIYDMLATKKFAINVATEAATTVLSIDQIIMAKKAGGPRA 555 + D + + A+ A A L+ + ++ K + Sbjct: 445 AAGVADPVKVTRSALQNAASIAGLFLTTEAVVADKPEKEKAS 486 >3LXD-A nrPDB Length = 415 Score = 40.1 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 37/215 (17%), Positives = 70/215 (32%), Gaps = 31/215 (14%) Query: 307 ELALHYLNRYGIL---VLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEI 363 L+ YL R ++ +E + + GA + A +LG ++ Sbjct: 52 PLSKEYLAREKTFERICIRPAQFWEDKAVEMKLGAEVVSLDPAAHTVKLGDGSAIE---- 107 Query: 364 GGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGA 423 G R + + R +D + L + ++ G Sbjct: 108 ----YGKLIWATGGDPRRLSCV---GADLAGVHAVRTKEDADRLMAELDAGAKNAVVIGG 160 Query: 424 GATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAHN 483 G +E + +TK+G E +PR LA AG E L Y A + Sbjct: 161 GYIGLEAAAVLTKFGVNVT------------LLEALPRVLARVAG----EALSEFYQAEH 204 Query: 484 VTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIY 518 ++T ++ DG GV+ +++ ++ Sbjct: 205 RAHGVDLRTGAAMDCIEGDGTKVTGVR-MQDGSVI 238 >3E0V-A nrPDB Length = 539 Score = 38.1 bits (87), Expect = 0.011, Method: Composition-based stats. Identities = 17/76 (22%), Positives = 31/76 (40%), Gaps = 11/76 (14%) Query: 21 YSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGK---------IIITNDAATM 71 D I + ++ ++GP GR+ +I+ + II +D + Sbjct: 243 EQGVDMIFASFIRSAEQVGD-VRKALGPKGRDIMIICKIENHQGVQNIDSIIEESDGIMV 301 Query: 72 LR-ELDIVHPAVKVLV 86 R +L + PA KV+V Sbjct: 302 ARGDLGVEIPAEKVVV 317 >4PLW-A nrPDB Length = 326 Score = 36.6 bits (83), Expect = 0.027, Method: Composition-based stats. Identities = 38/244 (15%), Positives = 73/244 (29%), Gaps = 20/244 (8%) Query: 209 VVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKKHKVAVFTCPLDIANTE---TKGTV 265 + + G + +++GM + + S K+ DI ++ + Sbjct: 23 IAQKELGDVVLFDIVEGMPQGKALDISHSSPIMGSNVKITGTNNYEDIKGSDVVIITAGI 82 Query: 266 LLHNAQEMLDFSKGEEKQIDAMMKEIADMGVE--CIVAGAGVGELALHYLNRYGILVLKV 323 D K + + + I IV + + + VL Sbjct: 83 PRKPGMSRDDLLSVNAKIMKDVAENIKKYCPNAFVIVVTNPLDVM---------VYVLHK 133 Query: 324 PSKFELRRLCRVCGATPLPRLGAPTPEELGLV-ETVKTMEIGG--DRVTVFKQEQGEISR 380 S ++C + G R E+L + V+ M IGG D + + Sbjct: 134 YSGLPHNKVCGMAGVLDSSRFRYFLAEKLNVSPNDVQAMVIGGHGDTMVPLTRYCTVGGI 193 Query: 381 TSTIILRGA--TQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPGAGATEIELISRITKYG 438 T ++ TQ +D+I + + L+K P A A E+ + Sbjct: 194 PLTEFIKQGWITQEEIDEIVERTRNAGGEIVNLLKTGSAYFAPAASAIEMAES-YLKDKK 252 Query: 439 ERTP 442 P Sbjct: 253 RILP 256 >2GJN-A nrPDB Length = 328 Score = 33.9 bits (76), Expect = 0.18, Method: Composition-based stats. Identities = 11/84 (13%), Positives = 29/84 (34%), Gaps = 4/84 (4%) Query: 356 ETVKTMEIGGDRVT----VFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGL 411 V + +G D + + I +R A + + D I R++ + + Sbjct: 186 GLVAALALGADAINMGTRFLATRECPIHPAVKAAIRAADERSTDLIMRSLRNTARVARNA 245 Query: 412 MKPSGGKLLPGAGATEIELISRIT 435 + + GA ++ + ++ Sbjct: 246 ISQEVLAIEARGGAGYADIAALVS 269 >3LFI-A nrPDB Length = 634 Score = 33.1 bits (74), Expect = 0.38, Method: Composition-based stats. Identities = 33/213 (15%), Positives = 70/213 (32%), Gaps = 28/213 (13%) Query: 365 GDRVTVFKQEQGEISRT----STIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLL 420 +F E+G +T T+ G+ + + +I D + A + Sbjct: 273 ETGNVLFLTEEGHDPQTGEVFVTLGTEGSGLPIVPQVS-SIHDMLWAAGEV--------- 322 Query: 421 PGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVP--RTLAETAGLDVNEVLP-- 476 +E E ++ G L +A A +V+P +++T+G++V+ + Sbjct: 323 --GVGSEQEGAK--VEFSPSMAGFLDWGFSAYAAAGKVLPASSAVSKTSGVEVDRYVSFV 378 Query: 477 NLYAAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAIN---VATE 533 L G + G +K EN+ D ++ ++ ++ Sbjct: 379 WLTGDQYEQADGFPTAQQGWTG---SLLLPRELKVQTVENVVDNELVREEGVSWVVGESD 435 Query: 534 AATTVLSIDQIIMAKKAGGPRAPQGPRPGNWDQ 566 T L I +A++ G D+ Sbjct: 436 NQTATLRTLGITIARETKAALLANGSVTAEEDR 468 >4KRZ-A nrPDB Length = 519 Score = 32.3 bits (72), Expect = 0.62, Method: Composition-based stats. Identities = 15/76 (19%), Positives = 31/76 (40%), Gaps = 11/76 (14%) Query: 21 YSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGK---------IIITNDAATM 71 D I ++ + ++G G++ +I++ + II +D + Sbjct: 223 EQGIDMVFASFIRTAEQVQE-VREALGEKGKDILIISKIENHQGVQNIDGIIEASDGIMV 281 Query: 72 LR-ELDIVHPAVKVLV 86 R +L + PA KV+V Sbjct: 282 ARGDLGVEIPAEKVVV 297 >4N7R-A nrPDB Length = 472 Score = 32.0 bits (71), Expect = 0.67, Method: Composition-based stats. Identities = 31/227 (13%), Positives = 69/227 (30%), Gaps = 27/227 (11%) Query: 298 CIVAGAGVGELALHYLNRYGILVLKVPSKFELRRLC----RVCGATPLPRLGAPTPEELG 353 C++ +G+L + +L G + V ++ E R+ + G + R Sbjct: 211 CVIGAGKMGKLVIKHLMAKGCTKVVVVNRSE-ERVSAIREEMPGIEIIYRPLDEMLACAS 269 Query: 354 LVETVKTMEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLD-DIERAIDDGVAAV--KG 410 + V T + + + + + + G ++ +D + R + V V Sbjct: 270 EADVVFTSTASETPLFLKEHVENLPQASPEV---GGLRHFVDISVPRNVGSCVGEVETAR 326 Query: 411 LMKPSGGKLLPGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLD 470 + K + A E R + + + + E VP Sbjct: 327 VYNVDDLKEVV---AANKEDRMRKAMEAQTIITEESTQFEAWRDSLETVP---------- 373 Query: 471 VNEVLPNLYAAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENI 517 + L A ++ G DI+ ++ V D+ + Sbjct: 374 ---TIKKLRAYAERIRVAELEKCMSKMGDDINKKTTRAVDDLSRGIV 417 >4FLV-A nrPDB Length = 793 Score = 32.0 bits (71), Expect = 0.69, Method: Composition-based stats. Identities = 18/125 (14%), Positives = 43/125 (34%), Gaps = 12/125 (9%) Query: 226 MVFNREPEGHVKSLSEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQID 285 + + E H K + + + A T ++ L ++ E + I Sbjct: 160 LAVDIETLYHEGE-EFGKGPIIMISYADEEGAKVITWKSIDLP----YVEVVSSEREMIK 214 Query: 286 AMMKEIADMGVECIVAGAGVGELALHYLNRY------GILVLKVPSKFELRRLCRVCGAT 339 ++K I + + I+ G A YL + + + + S+ +++R+ Sbjct: 215 RLVKVIREKDPDVIITYNG-DNFAFPYLLKRAEKLGIKLPLGRDNSEPKMQRMGDSLAVE 273 Query: 340 PLPRL 344 R+ Sbjct: 274 IKGRI 278 >3OLJ-A nrPDB Length = 286 Score = 31.6 bits (70), Expect = 1.0, Method: Composition-based stats. Identities = 30/219 (13%), Positives = 74/219 (33%), Gaps = 25/219 (11%) Query: 115 EKLISMGLSAVEIIQ-----GYNMARKFTLKELDEMVVGE-ITDKNDKNELLKMIKP--V 166 E L+ V+I + G+ +A + E+ +++ I D ++ L I+ Sbjct: 79 ENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPC 138 Query: 167 ISSKKYGSEDILSELVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGM 226 + K + + + + V+ A G + SI +K G ++ G+ Sbjct: 139 VKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRG-------LMPGL 191 Query: 227 VFNREPEGHVKSLSEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDA 286 F+ E S E A + + + +++ + E++ + Sbjct: 192 TFSNELI----SRDEGLHCDFACLMFKHLVHKPSEERVREI-----IINAVRIEQEFLTE 242 Query: 287 MMKEIADMGVECIVAGAGVGELALHYLNRYGILVLKVPS 325 + + +G+ C + + +A + G + Sbjct: 243 ALP-VKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVE 280 >5H12-A nrPDB Length = 775 Score = 31.6 bits (70), Expect = 1.0, Method: Composition-based stats. Identities = 22/166 (13%), Positives = 53/166 (31%), Gaps = 20/166 (12%) Query: 185 AVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREPEGHVKSLSEDKK 244 AV + + + I + + + K + F+ E H E K Sbjct: 105 AVIDIFEYDIPFAKRYLIDKGLIPMEG-------DEEL-KLLAFDIETLYHEG--EEFAK 154 Query: 245 HKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAGAG 304 + + + + + + ++ E + I +K I + + I+ G Sbjct: 155 GPIIMISYADE-EEAKVITWKKIDLP--YVEVVSSEREMIKRFLKVIREKDPDVIITYNG 211 Query: 305 VGELALHYLNRY------GILVLKVPSKFELRRLCRVCGATPLPRL 344 L YL + + + + S+ +++RL + R+ Sbjct: 212 -DSFDLPYLVKRAEKLGIKLPLGRDGSEPKMQRLGDMTAVEIKGRI 256 >3L6X-A nrPDB Length = 584 Score = 31.2 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 17/89 (19%), Positives = 32/89 (35%), Gaps = 9/89 (10%) Query: 310 LHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPE-ELGLVETVKTMEIGGDRV 368 H R + K ++R+L + + L P E LG +K + G D+ Sbjct: 73 QHLCYRNDKV------KTDVRKLKGI--PVLVGLLDHPKKEVHLGACGALKNISFGRDQD 124 Query: 369 TVFKQEQGEISRTSTIILRGATQNNLDDI 397 + + +LR A +L ++ Sbjct: 125 NKIAIKNCDGVPALVRLLRKARDMDLTEV 153 >3GEE-A nrPDB Length = 476 Score = 30.8 bits (68), Expect = 1.6, Method: Composition-based stats. Identities = 16/81 (19%), Positives = 31/81 (38%), Gaps = 10/81 (12%) Query: 67 DAATMLRELDIVHPAVKVLVMATEQQK--------IDMGDGTNLVMILAGELLNVSEKLI 118 D T +REL HPA K L +A + + + DGT +I L + Sbjct: 329 DELTEIRELKAAHPAAKFLTVANKLDRAANADALIRAIADGTGTEVIGISALNGDGIDTL 388 Query: 119 SMGLSAVEIIQGYNMARKFTL 139 ++++ + + ++ Sbjct: 389 KQ--HMGDLVKNLDKLHEASV 407 >2VHI-A nrPDB Length = 405 Score = 30.8 bits (68), Expect = 1.6, Method: Composition-based stats. Identities = 4/42 (9%), Positives = 16/42 (38%) Query: 261 TKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAG 302 + ++++ + + ++ M+K A+ G + Sbjct: 78 IQNSIVIPTTAPIEKQREAIWNKVKTMIKAAAEAGCNIVCTQ 119 >4A61-A nrPDB Length = 326 Score = 30.8 bits (68), Expect = 1.8, Method: Composition-based stats. Identities = 22/87 (25%), Positives = 33/87 (37%), Gaps = 7/87 (8%) Query: 119 SMGLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVIS--SKKYGSED 176 + + I GY L+ELDE I D + + +S SK YG Sbjct: 148 DVKVMPESIPAGYE-----VLQELDERDSLLIIDLGGTTLDISQVMGKLSGISKIYGDSS 202 Query: 177 ILSELVSEAVSHVLPVAQQAGEIPYFN 203 + LV+ AV L +A+ G + Sbjct: 203 LGVSLVTSAVKDALSLARTKGSSYLAD 229 >3OZ2-A nrPDB Length = 397 Score = 30.4 bits (67), Expect = 2.1, Method: Composition-based stats. Identities = 26/162 (16%), Positives = 57/162 (35%), Gaps = 15/162 (9%) Query: 51 RNKIIVNHLG-----KIIITNDAATMLR-ELDIVHPAVKVLVMATEQQKIDMGDGTNLVM 104 ++ I NH G I + ++ + ++ I P + ++ A G G + Sbjct: 242 LDRFIENHPGLKKGQDIQLVTGGVSVSKVKMPITMPGLMLVGDAARLIDPITGGGIANAI 301 Query: 105 ILAGELLNVSEKLISMGLSAVEIIQGYNMARKFTLKE--LDEMVVGEITDKNDKNELLKM 162 + V+++ I + +++Q Y K + L V E + L K+ Sbjct: 302 VSGMYAAQVTKEAIESNDYSPQMMQKYEKLIKERFERKHLRNWVAKEKLAMLSDDTLDKL 361 Query: 163 IKPVISSKKYGSEDILSELVSEAVSHVLPVAQQAGEIPYFNV 204 + V SE +L+ + EA+ + ++ Sbjct: 362 VDIV-------SEQVLTTISVEAILKAIAEKYPEVVKELEDL 396 >2ZVC-A nrPDB Length = 295 Score = 29.7 bits (65), Expect = 3.9, Method: Composition-based stats. Identities = 24/112 (21%), Positives = 44/112 (39%), Gaps = 8/112 (7%) Query: 360 TMEIGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKL 419 + IG +E G ++ ++ +G T+ LD E A++ ++ + + G Sbjct: 29 EVVIGYSTYVKLLEEMGLLAGK-EVVRKGMTEE-LDRAEEALERALSGQRVALVSGGDPG 86 Query: 420 LPGAGATEIEL----ISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETA 467 + G A +EL + G PG A ++ V V+P A A Sbjct: 87 IYGMAAPVLELMEERGLKRVDGGVGLPGR--FAGEEGEVFLAVIPGVTAANA 136 >3D31-A nrPDB Length = 348 Score = 29.3 bits (64), Expect = 4.5, Method: Composition-based stats. Identities = 33/218 (15%), Positives = 68/218 (31%), Gaps = 34/218 (15%) Query: 238 SLSEDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQI------DAMMKEI 291 + + K+ + PL + T+ NA+EML + K D I Sbjct: 139 ARALVTNPKILLLDEPLSALDPRTQ-----ENAREMLSVLHKKNKLTVLHITHDQTEARI 193 Query: 292 ADMGVECIVAGAGVG-ELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPE 350 + ++ G + + + +V S + + + Sbjct: 194 MADRIAVVMDGKLIQVGKPEEIFEKP--VEGRVASFVGFENVLK---GRVISAEQGLLRI 248 Query: 351 ELGLV--ETVKTMEIGGDRVTVFKQEQGEISRTST-IILRGATQNNLDDIERAIDDGVAA 407 +G V + ME+G + E +S++ST +R + Q + + Sbjct: 249 RVGEVVIDAAGDMEVGDQVYAFLRPENIALSKSSTQSSIRNSLQGRVTEA--------WV 300 Query: 408 VKGLMKPSGGKLLPGA------GATEIELISRITKYGE 439 + L++ +P A E+EL + Y Sbjct: 301 LGALVRVKVDCGVPLNVLITRRSAEEMELSPGVQIYAR 338 >4CBQ-A nrPDB Length = 314 Score = 29.3 bits (64), Expect = 4.9, Method: Composition-based stats. Identities = 18/96 (18%), Positives = 34/96 (35%), Gaps = 13/96 (13%) Query: 356 ETVKTMEIGGDRVTVFKQEQGEISRTSTIILRGATQ---NNLDDIERAIDDGVAAVKGLM 412 ET+ ++ +F +E E+ S II GAT + + + + + Sbjct: 86 ETIDHVDFSTQPFKLFTEEGKEVLTKSVIIATGATAKRMHVPGEDKYWQN---GVSACAI 142 Query: 413 KPSGGKL-------LPGAGATEIELISRITKYGERT 441 + + G G +E +TKYG + Sbjct: 143 CDGAVPIFRNKVLMVVGGGDAAMEEALHLTKYGSKV 178 >2GF2-A nrPDB Length = 296 Score = 28.9 bits (63), Expect = 7.0, Method: Composition-based stats. Identities = 16/113 (14%), Positives = 43/113 (38%), Gaps = 4/113 (3%) Query: 114 SEKLISMGLSAVEIIQGYNMARKFTLKELDEMVVGEITDKNDKNELLKMIKPVISSKKYG 173 ++ L+ G + I + A K +++V + ++ M+ I++ + Sbjct: 16 AKNLMKHG-YPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIITMLPTSINAIEAY 74 Query: 174 SEDILSELVSEAVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGM 226 S + + + V + + P + + + V+ MG ++ V G+ Sbjct: 75 SG---ANGILKKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMDAPVSGGV 124 >1UF2-K nrPDB Length = 506 Score = 28.5 bits (62), Expect = 7.2, Method: Composition-based stats. Identities = 12/60 (20%), Positives = 21/60 (35%), Gaps = 7/60 (11%) Query: 300 VAGAGVGELALHYLNRYGILV-------LKVPSKFELRRLCRVCGATPLPRLGAPTPEEL 352 + G+ ++L L GILV ++ K +L G + + E L Sbjct: 440 LTKNGISVVSLDELTDAGILVESTGPDRVRRSPKVLANKLSSFKGRKVTLDVDNMSTEAL 499 >2IOU-G nrPDB Length = 535 Score = 28.5 bits (62), Expect = 7.6, Method: Composition-based stats. Identities = 17/88 (19%), Positives = 31/88 (35%), Gaps = 8/88 (9%) Query: 308 LALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTMEIGGDR 367 +A L G + ++ + ++R V G + L PE+L V +G Sbjct: 118 IADSTLQGAGGVRVERGANVTVQRSTIVDGGLHIGTLQPLQPEDLPPSRVV----LGDTS 173 Query: 368 VTVFKQEQGEISRTSTIILRGATQNNLD 395 VT ++ GA + +D Sbjct: 174 VTAVPASGA--PAAVSVF--GANELTVD 197 >4PLF-A nrPDB Length = 334 Score = 28.1 bits (61), Expect = 9.8, Method: Composition-based stats. Identities = 33/195 (16%), Positives = 59/195 (30%), Gaps = 22/195 (11%) Query: 242 DKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVE--CI 299 K V + T L A ++ D K + + + I I Sbjct: 74 IKGSDVVIITAGLTKAPGKSDKEWS------RDDLLPFNAKIMREVGENIKKYCPNAFVI 127 Query: 300 VAGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVET-V 358 V + + + VL S ++C + G R E+L + V Sbjct: 128 VITNPLDVM---------VKVLHEHSGLPKNKVCGMAGVLDSSRFRHFIAEKLNVSPRDV 178 Query: 359 KTMEIG--GDRVTVFKQEQGEISRTSTIILRGA--TQNNLDDIERAIDDGVAAVKGLMKP 414 + M IG GD++ + ++ TQ +D+I + + L+ Sbjct: 179 QAMVIGAHGDKMVPLTRYVTVNGIPLQEFIKKGRITQEEIDEIVERTKNAGGEIVNLLGQ 238 Query: 415 SGGKLLPGAGATEIE 429 P A A E+ Sbjct: 239 GSAYFAPAASAIEMA 253 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.308 0.133 0.332 Lambda K H 0.267 0.0412 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 19,583,277 Number of Sequences: 36641 Number of extensions: 764186 Number of successful extensions: 2913 Number of sequences better than 10.0: 65 Number of HSP's better than 10.0 without gapping: 80 Number of HSP's successfully gapped in prelim test: 35 Number of HSP's that attempted gapping in prelim test: 2508 Number of HSP's gapped (non-prelim): 128 length of query: 568 length of database: 10,336,785 effective HSP length: 102 effective length of query: 466 effective length of database: 6,599,403 effective search space: 3075321798 effective search space used: 3075321798 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 62 (28.5 bits)