BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P47039 (444 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3B46-A nrPDB 918 0.0 1YIY-A nrPDB 247 6e-66 2ZJG-A nrPDB 241 6e-64 4WP0-A nrPDB 240 8e-64 3FVS-A nrPDB 240 9e-64 1V2E-A nrPDB 225 4e-59 1U08-A nrPDB 181 6e-46 2O0R-A nrPDB 177 6e-45 1GC4-A nrPDB 158 6e-39 1GDE-A nrPDB 156 1e-38 1O4S-A nrPDB 152 2e-37 6F77-B nrPDB 139 2e-33 4MY5-A nrPDB 122 3e-28 6F35-A nrPDB 119 2e-27 1J32-A nrPDB 119 4e-27 2GB3-A nrPDB 116 2e-26 2Z61-A nrPDB 107 1e-23 3DYD-A nrPDB 107 1e-23 4CVQ-A nrPDB 106 2e-23 1XI9-A nrPDB 106 3e-23 4IX8-A nrPDB 106 3e-23 5WMH-A nrPDB 105 4e-23 3PDX-A nrPDB 103 2e-22 3T32-A nrPDB 97 1e-20 2O1B-A nrPDB 92 3e-19 4DQ6-A nrPDB 92 3e-19 1BW0-A nrPDB 92 4e-19 5YHV-A nrPDB 92 6e-19 3H14-A nrPDB 87 2e-17 3B1C-A nrPDB 87 2e-17 2X5D-A nrPDB 85 5e-17 3ELE-A nrPDB 84 1e-16 3L8A-A nrPDB 78 7e-15 2ZC0-A nrPDB 75 8e-14 1C7O-A nrPDB 74 9e-14 3OP7-A nrPDB 73 2e-13 3DZZ-A nrPDB 67 2e-11 3F6T-A nrPDB 65 7e-11 2ZY3-A nrPDB 64 1e-10 4M2J-A nrPDB 62 4e-10 5Z0Q-C nrPDB 61 1e-09 3EZS-A nrPDB 60 2e-09 1D2F-A nrPDB 60 3e-09 1IAY-A nrPDB 59 4e-09 3NRA-A nrPDB 59 5e-09 3FDD-A nrPDB 58 9e-09 2ZY2-A nrPDB 56 3e-08 3G0T-A nrPDB 56 3e-08 3JTX-A nrPDB 56 3e-08 2DOU-A nrPDB 55 5e-08 4GDY-A nrPDB 55 8e-08 3TCM-A nrPDB 53 2e-07 1IJI-A nrPDB 52 3e-07 1M4N-A nrPDB 52 5e-07 6HNB-A nrPDB 51 1e-06 6HNV-A nrPDB 50 1e-06 3IF2-A nrPDB 50 3e-06 3FDB-A nrPDB 50 3e-06 2ZYJ-A nrPDB 49 4e-06 3EI8-A nrPDB 49 5e-06 3ASB-A nrPDB 49 6e-06 1X0M-A nrPDB 49 6e-06 4FL0-A nrPDB 48 8e-06 3AV7-A nrPDB 48 8e-06 1WST-A nrPDB 47 2e-05 4JE5-A nrPDB 47 2e-05 3LY1-A nrPDB 46 3e-05 1VP4-A nrPDB 45 5e-05 3CQ5-A nrPDB 45 5e-05 3IHJ-A nrPDB 45 6e-05 1AY8-A nrPDB 44 1e-04 3QGU-A nrPDB 44 2e-04 3G7Q-A nrPDB 43 2e-04 1UU1-A nrPDB 43 3e-04 3FFH-A nrPDB 42 5e-04 4R2N-A nrPDB 42 6e-04 5DJ3-A nrPDB 42 7e-04 5WT2-A nrPDB 41 8e-04 3UWC-A nrPDB 41 9e-04 4K2M-A nrPDB 40 0.002 2X5F-A nrPDB 39 0.003 6CJB-A nrPDB 38 0.009 3GET-A nrPDB 37 0.013 5TSU-A nrPDB 37 0.016 4PIW-A nrPDB 37 0.020 3FTB-A nrPDB 36 0.026 4IYO-A nrPDB 36 0.029 4L0O-H nrPDB 36 0.031 6BLG-A nrPDB 36 0.039 5K8B-A nrPDB 33 0.18 1LC8-A nrPDB 33 0.18 3NYS-A nrPDB 33 0.19 3EUC-A nrPDB 33 0.19 4C9K-A nrPDB 33 0.29 3NDN-A nrPDB 33 0.30 2C81-A nrPDB 33 0.35 3HDO-A nrPDB 33 0.37 2CB1-A nrPDB 32 0.74 4W91-A nrPDB 31 1.3 4RAE-A nrPDB 30 1.5 3SKS-A nrPDB 30 1.8 4ZTY-A nrPDB 30 2.5 2VNA-A nrPDB 29 4.2 4K8W-A nrPDB 29 4.7 4PLF-A nrPDB 28 6.8 >3B46-A nrPDB Length = 447 Score = 918 bits (2372), Expect = 0.0, Method: Compositional matrix adjust. Identities = 444/444 (100%), Positives = 444/444 (100%) Query: 1 MKQRFIRQFTNLMSTSRPKVVANKYFTSNTAKDVWSLTNEAAAKAANNSKNQGRELINLG 60 MKQRFIRQFTNLMSTSRPKVVANKYFTSNTAKDVWSLTNEAAAKAANNSKNQGRELINLG Sbjct: 4 MKQRFIRQFTNLMSTSRPKVVANKYFTSNTAKDVWSLTNEAAAKAANNSKNQGRELINLG 63 Query: 61 QGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTV 120 QGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTV Sbjct: 64 QGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTV 123 Query: 121 TTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTR 180 TTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTR Sbjct: 124 TTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTR 183 Query: 181 GEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVY 240 GEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVY Sbjct: 184 GEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVY 243 Query: 241 EHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTR 300 EHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTR Sbjct: 244 EHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTR 303 Query: 301 ICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFV 360 ICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFV Sbjct: 304 ICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFV 363 Query: 361 LVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLR 420 LVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLR Sbjct: 364 LVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLR 423 Query: 421 FAVCKDDAYLENAVERLKLLKDYL 444 FAVCKDDAYLENAVERLKLLKDYL Sbjct: 424 FAVCKDDAYLENAVERLKLLKDYL 447 >1YIY-A nrPDB Length = 429 Score = 247 bits (631), Expect = 6e-66, Method: Compositional matrix adjust. Identities = 143/394 (36%), Positives = 211/394 (53%), Gaps = 16/394 (4%) Query: 57 INLGQGFFSYSPPQFAIKEAQKALDIP--MVNQYSPTRGRPSLINSLIKLYSPIYNTELK 114 +NLGQGF Y P++A+ A + P + NQY+ G P L+ +L KLYS + + + Sbjct: 40 LNLGQGFPDYHAPKYALNALAAAANSPDPLANQYTRGFGHPRLVQALSKLYSQLVDRTIN 99 Query: 115 -AENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKE 173 V VT GA E + + + G ++ GDEVI+ EPFFD Y P ++ GG ++P+ P K Sbjct: 100 PMTEVLVTVGAYEALYATIQGHVDEGDEVIIIEPFFDCYEPMVKAAGGIPRFIPLKPNK- 158 Query: 174 LDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVV 233 +W +D + E KTK +IINTPHNP+GKV R EL + N+C K NV+ Sbjct: 159 -TGGTISSADWVLDNNELEALFNEKTKMIIINTPHNPLGKVMDRAELEVVANLCKKWNVL 217 Query: 234 IISDEVYEHLYFTD-SFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLS 292 +SDEVYEH+ F RI TL P + + T+T+GSAGK+F+ TGW+IGW A LL Sbjct: 218 CVSDEVYEHMVFEPFEHIRICTL-PGMWERTITIGSAGKTFSLTGWKIGWAYGPEA-LLK 275 Query: 293 YAAKAHTRICFASPSPLQEACANSINDALKI-----GYFEKMRQEYINKFKIFTSIFDEL 347 H + +P+QEA A LK YF + E + K S E+ Sbjct: 276 NLQMVHQNCVYTCATPIQEAIAVGFETELKRLKSPECYFNSISGELMAKRDYMASFLAEV 335 Query: 348 GLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFY 407 G+ T P+G YF++ D+S + D + + KD+R + W+ +G+ IPP+ FY Sbjct: 336 GMNPTVPQGGYFMVADWSSLDSKVDL---TQETDARKDYRFTKWMTKSVGLQGIPPSAFY 392 Query: 408 IKEHEKAAENLLRFAVCKDDAYLENAVERLKLLK 441 + ++ E+ +R+ K D L+ A E L+ K Sbjct: 393 SEPNKHLGEDFVRYCFFKKDENLQKAAEILRKWK 426 >2ZJG-A nrPDB Length = 410 Score = 241 bits (614), Expect = 6e-64, Method: Compositional matrix adjust. Identities = 137/392 (34%), Positives = 212/392 (54%), Gaps = 24/392 (6%) Query: 56 LINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKA 115 ++NLGQGF SPP + +E KA I +NQY+ G P+L+ +L LY IY ++ Sbjct: 25 VVNLGQGFPDISPPSYVKEELSKAAFIDNMNQYTRGFGHPALVKALSCLYGKIYQRQIDP 84 Query: 116 -ENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKEL 174 E + V GA + + + GL++ GDEVI+ PF+D Y P + + G V++P+ K Sbjct: 85 NEEILVAVGAYGSLFNSIQGLVDPGDEVIIMVPFYDCYEPMVRMAGAVPVFIPLRS-KPT 143 Query: 175 DQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVI 234 D +WT D + E +SKTKA+I+NTPHNP+GKV+TR+EL + ++CVKH+ + Sbjct: 144 DGMKWTSSDWTFDPRELESKFSSKTKAIILNTPHNPLGKVYTRQELQVIADLCVKHDTLC 203 Query: 235 ISDEVYEHLYFT-DSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSY 293 ISDEVYE L +T + +IATL P + + T+T+GSAGK+F+ TGW++GW + A L+ + Sbjct: 204 ISDEVYEWLVYTGHTHVKIATL-PGMWERTITIGSAGKTFSVTGWKLGWSIG-PAHLIKH 261 Query: 294 AAKAHTRICFASPSPLQEACANSINDALKI-----GYFEKMRQEYINKFKIFTSIFDELG 348 + +PLQ A A + +K YF + +E K + + +G Sbjct: 262 LQTVQQNSFYTCATPLQAALAEAFWIDIKRMDDPECYFNSLPKELEVKRDRMVRLLNSVG 321 Query: 349 LPYTAPEGTYFVLVDFSKV-----KIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPP 403 L P+G YF++ D S + + D PY D++ W+ + AIP Sbjct: 322 LKPIVPDGGYFIIADVSSLGADLSDMNSDEPY---------DYKFVKWMTKHKKLTAIPV 372 Query: 404 TEFYIKEHEKAAENLLRFAVCKDDAYLENAVE 435 + F + + E L+RF K D+ L+ A E Sbjct: 373 SAFCDSKSKPHFEKLVRFCFIKKDSTLDAAEE 404 >4WP0-A nrPDB Length = 472 Score = 240 bits (613), Expect = 8e-64, Method: Compositional matrix adjust. Identities = 141/403 (34%), Positives = 214/403 (53%), Gaps = 26/403 (6%) Query: 54 RELINLGQGFFSYSPPQFAIKEAQKALDIP-MVNQYSPTRGRPSLINSLIKLYSPIYNTE 112 +++NLGQGF + PP FA++ Q A+ M+NQY+ T G P L L + + E Sbjct: 28 HDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFMLNQYTKTFGYPPLTKILASFFGELLGQE 87 Query: 113 LKA-ENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPP 171 + NV VT G + + L++ GDEVI+ EPFFD Y P + GG+ V+V + P Sbjct: 88 IDPLRNVLVTVGGYGALFTAFQALVDEGDEVIIIEPFFDCYEPMTMMAGGRPVFVSLKPG 147 Query: 172 KELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHN 231 + W +D + TS+TKA+++NTP+NP+GKVF+REEL + ++C +H+ Sbjct: 148 PIQNGELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVFSREELELVASLCQQHD 207 Query: 232 VVIISDEVYEHLYFTDSFTRIATLS-PEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAEL 290 VV I+DEVY+ + + D I+ S P + + TLT+GSAGK+F+ATGW++GWVL + + Sbjct: 208 VVCITDEVYQWMVY-DGHQHISIASLPGMWERTLTIGSAGKTFSATGWKVGWVLGPD-HI 265 Query: 291 LSYAAKAHTRICFASPSPLQEACANSINDALKI-----GYFEKMRQEYINKFKIFTSIFD 345 + + H F P+ Q A A S + YF + Q Sbjct: 266 MKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFRQPSSYFVQFPQAMQRCRDHMIRSLQ 325 Query: 346 ELGLPYTAPEGTYFVLVDFS--KVKIPE-----DYPYPEEILNKGKDFRISHWLINELGV 398 +GL P+G+YF++ D S K K+P+ D PY D R W+I G+ Sbjct: 326 SVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDEPY---------DRRFVKWMIKNKGL 376 Query: 399 VAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLK 441 VAIP + FY H+K ++ +RF KD+A L+ E+L+ K Sbjct: 377 VAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWK 419 >3FVS-A nrPDB Length = 422 Score = 240 bits (612), Expect = 9e-64, Method: Compositional matrix adjust. Identities = 141/403 (34%), Positives = 214/403 (53%), Gaps = 26/403 (6%) Query: 54 RELINLGQGFFSYSPPQFAIKEAQKALDIP-MVNQYSPTRGRPSLINSLIKLYSPIYNTE 112 +++NLGQGF + PP FA++ Q A+ M+NQY+ T G P L L + + E Sbjct: 28 HDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFMLNQYTKTFGYPPLTKILASFFGELLGQE 87 Query: 113 LKA-ENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPP 171 + NV VT G + + L++ GDEVI+ EPFFD Y P + GG+ V+V + P Sbjct: 88 IDPLRNVLVTVGGYGALFTAFQALVDEGDEVIIIEPFFDCYEPMTMMAGGRPVFVSLKPG 147 Query: 172 KELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHN 231 + W +D + TS+TKA+++NTP+NP+GKVF+REEL + ++C +H+ Sbjct: 148 PIQNGELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVFSREELELVASLCQQHD 207 Query: 232 VVIISDEVYEHLYFTDSFTRIATLS-PEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAEL 290 VV I+DEVY+ + + D I+ S P + + TLT+GSAGK+F+ATGW++GWVL + + Sbjct: 208 VVCITDEVYQWMVY-DGHQHISIASLPGMWERTLTIGSAGKTFSATGWKVGWVLGPD-HI 265 Query: 291 LSYAAKAHTRICFASPSPLQEACANSINDALKI-----GYFEKMRQEYINKFKIFTSIFD 345 + + H F P+ Q A A S + YF + Q Sbjct: 266 MKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFRQPSSYFVQFPQAMQRCRDHMIRSLQ 325 Query: 346 ELGLPYTAPEGTYFVLVDFS--KVKIPE-----DYPYPEEILNKGKDFRISHWLINELGV 398 +GL P+G+YF++ D S K K+P+ D PY D R W+I G+ Sbjct: 326 SVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDEPY---------DRRFVKWMIKNKGL 376 Query: 399 VAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLK 441 VAIP + FY H+K ++ +RF KD+A L+ E+L+ K Sbjct: 377 VAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWK 419 >1V2E-A nrPDB Length = 381 Score = 225 bits (573), Expect = 4e-59, Method: Compositional matrix adjust. Identities = 132/383 (34%), Positives = 203/383 (53%), Gaps = 48/383 (12%) Query: 57 INLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAE 116 +NLGQGF S PP F ++ ++AL +QY+P G P+L +L + ++ ++ E Sbjct: 28 VNLGQGFPSNPPPPFLLEAVRRALG--RQDQYAPPAGLPALREALAEEFA------VEPE 79 Query: 117 NVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGK--VVYVPINPPKEL 174 +V VT+GA E + L L+ GDEV+V EPFFD Y+P+ L G K +V + + P Sbjct: 80 SVVVTSGATEALYVLLQSLVGPGDEVVVLEPFFDVYLPDAFLAGAKARLVRLDLTP---- 135 Query: 175 DQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVI 234 E + +D EKA+T +T+A+++NTP NP G VF EL + + H++ + Sbjct: 136 -------EGFRLDLSALEKALTPRTRALLLNTPMNPTGLVFGERELEAIARLARAHDLFL 188 Query: 235 ISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYA 294 ISDEVY+ LY+ + R+ +PE T TVGSAGK ATG+R+GW++ E + Sbjct: 189 ISDEVYDELYYGERPRRLREFAPE---RTFTVGSAGKRLEATGYRVGWIVG-PKEFMPRL 244 Query: 295 AKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAP 354 A F++P+PLQ A ++ A + G++E +R+ Y + + +GL P Sbjct: 245 AGMRQWTSFSAPTPLQAGVAEALKLARREGFYEALREGYRRRRDLLAGGLRAMGLRVYVP 304 Query: 355 EGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKA 414 EGTYF++ + L FR L+ E V IP + FY+++ K Sbjct: 305 EGTYFLMAE----------------LPGWDAFR----LVEEARVALIPASAFYLEDPPK- 343 Query: 415 AENLLRFAVCKDDAYLENAVERL 437 +L RFA CK + L A+ERL Sbjct: 344 --DLFRFAFCKTEEELHLALERL 364 >1U08-A nrPDB Length = 386 Score = 181 bits (459), Expect = 6e-46, Method: Compositional matrix adjust. Identities = 116/393 (29%), Positives = 192/393 (48%), Gaps = 38/393 (9%) Query: 52 QGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNT 111 Q + INL QGF + P++ ++E NQY+P G +L ++ + +Y Sbjct: 28 QQHQAINLSQGFPDFDGPRY-LQERLAHHVAQGANQYAPMTGVQALREAIAQKTERLYGY 86 Query: 112 ELKAE-NVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINP 170 + A+ ++TVT GA E + + + L+ GDEVI F+P +D Y P I L GG V + + P Sbjct: 87 QPDADSDITVTAGATEALYAAITALVRNGDEVICFDPSYDSYAPAIALSGGIVKRMALQP 146 Query: 171 PKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKH 230 P + +D+++F ++ +T+ VI+NTPHNP V+ + + L H Sbjct: 147 P-----------HFRVDWQEFAALLSERTRLVILNTPHNPSATVWQQADFAALWQAIAGH 195 Query: 231 NVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLS---LN 287 + +ISDEVYEH+ F+ P++ + + V S GK++ TGW++G+ ++ ++ Sbjct: 196 EIFVISDEVYEHINFSQQGHASVLAHPQLRERAVAVSSFGKTYHMTGWKVGYCVAPAPIS 255 Query: 288 AELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDEL 347 AE+ K H + F+ +P Q A A+ + + ++ + Y K I + +E Sbjct: 256 AEI----RKVHQYLTFSVNTPAQLALADMLR--AEPEHYLALPDFYRQKRDILVNALNES 309 Query: 348 GLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFY 407 L EGTYF+LVD+S V +D + WL E GV AIP + F Sbjct: 310 RLEILPCEGTYFLLVDYSAVSTLDDVEF-------------CQWLTQEHGVAAIPLSVFC 356 Query: 408 IKEHEKAAENLLRFAVCKDDAYLENAVERLKLL 440 + L+R K ++ L A ERL+ L Sbjct: 357 A---DPFPHKLIRLCFAKKESTLLAAAERLRQL 386 >2O0R-A nrPDB Length = 411 Score = 177 bits (450), Expect = 6e-45, Method: Compositional matrix adjust. Identities = 121/393 (30%), Positives = 186/393 (47%), Gaps = 33/393 (8%) Query: 57 INLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAE 116 +NLGQGF P ++ AQ A+ VNQY P G L ++ + + E Sbjct: 28 VNLGQGFPDEDGPPKMLQAAQDAI-AGGVNQYPPGPGSAPLRRAIAAQRRRHFGVDYDPE 86 Query: 117 N-VTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELD 175 V VT GA E I + ++GL+ G EV++ EPF+D Y P + + G V VP+ P Sbjct: 87 TEVLVTVGATEAIAAAVLGLVEPGSEVLLIEPFYDSYSPVVAMAGAHRVTVPLVP----- 141 Query: 176 QRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVII 235 G + +D + +A+T +T+A+IIN+PHNP G V + EL + I V N+V+I Sbjct: 142 ----DGRGFALDADALRRAVTPRTRALIINSPHNPTGAVLSATELAAIAEIAVAANLVVI 197 Query: 236 SDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAA 295 +DEVYEHL F + + + T+T+ SA K F TGW+IGW AEL++ Sbjct: 198 TDEVYEHLVFDHARHLPLAGFDGMAERTITISSAAKMFNCTGWKIGWACG-PAELIAGVR 256 Query: 296 KAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPE 355 A + + +P Q A A +++ + + +R + + E+G Sbjct: 257 AAKQYLSYVGGAPFQPAVALALD--TEDAWVAALRNSLRARRDRLAAGLTEIGFAVHDSY 314 Query: 356 GTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAA 415 GTYF+ D P P L L ++GV AIP + F +A+ Sbjct: 315 GTYFLCAD----------PRP---LGYDDSTEFCAALPEKVGVAAIPMSAFCDPAAGQAS 361 Query: 416 E------NLLRFAVCKDDAYLENAVERLKLLKD 442 + +L+RF CK D L+ A+ RL +L + Sbjct: 362 QQADVWNHLVRFTFCKRDDTLDEAIRRLSVLAE 394 >1GC4-A nrPDB Length = 385 Score = 158 bits (399), Expect = 6e-39, Method: Compositional matrix adjust. Identities = 113/390 (28%), Positives = 183/390 (46%), Gaps = 40/390 (10%) Query: 50 KNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIY 109 + QG +L+ L G + P+ + A++AL +Y+P G P L +L + + Sbjct: 27 RRQGVDLVALTAGEPDFDTPEHVKEAARRAL-AQGKTKYAPPAGIPELREALAEKFRREN 85 Query: 110 NTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPIN 169 + E VT G ++ + + +L+ GDEVIV P++ Y + GG VV V Sbjct: 86 GLSVTPEETIVTVGGSQALFNLFQAILDPGDEVIVLSPYWVSYPEMVRFAGGVVVEVETL 145 Query: 170 PPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVK 229 P E + D E+ +AIT +TKA+++N+P+NP G V+ +E L L + V+ Sbjct: 146 PE----------EGFVPDPERVRRAITPRTKALVVNSPNNPTGAVYPKEVLEALARLAVE 195 Query: 230 HNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAE 289 H+ ++SDE+YEHL + ++PE TLTV A K+FA TGWRIG+ Sbjct: 196 HDFYLVSDEIYEHLLYEGEHFSPGRVAPE---HTLTVNGAAKAFAMTGWRIGYACGPKEV 252 Query: 290 LLSYAAKAHTRICFASPSPL-QEACANSI-NDALKIGYFEKMRQEYINKFKIFTSIFDEL 347 + + A+ +R SP + Q A ++ N + E R+ Y + + L Sbjct: 253 IKAMASV--SRQSTTSPDTIAQWATLEALTNQEASRAFVEMAREAYRRRRDLLLEGLTAL 310 Query: 348 GLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFY 407 GL P G ++VL+D S + P+E+ R + L+ E GV +P T+F Sbjct: 311 GLKAVRPSGAFYVLMDTSPIA-------PDEV-------RAAERLL-EAGVAVVPGTDF- 354 Query: 408 IKEHEKAAENLLRFAVCKDDAYLENAVERL 437 AA +R + + L A+ER Sbjct: 355 ------AAFGHVRLSYATSEENLRKALERF 378 >1GDE-A nrPDB Length = 389 Score = 156 bits (395), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 119/406 (29%), Positives = 199/406 (49%), Gaps = 63/406 (15%) Query: 54 RELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTEL 113 +++I+LG G + PQ + A++ALD + + Y P G L++L I +L Sbjct: 26 KDVISLGIGEPDFDTPQHIKEYAKEALDKGLTH-YGPNIG-------LLELREAIAE-KL 76 Query: 114 KAEN---------VTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVV 164 K +N + V GAN+ L L L G+EV++ P F Y P + L GGK V Sbjct: 77 KKQNGIEADPKTEIMVLLGANQAFLMGLSAFLKDGEEVLIPTPAFVSYAPAVILAGGKPV 136 Query: 165 YVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLG 224 VP +E+ ++ ++ +K +T KT+A+IIN+P NP G V T+++L + Sbjct: 137 EVP----------TYEEDEFRLNVDELKKYVTDKTRALIINSPCNPTGAVLTKKDLEEIA 186 Query: 225 NICVKHNVVIISDEVYEHLYFTDS-FTRIATLSPEIGQLTLTVGSAGKSFAATGWRIG-- 281 + V+H++++ISDEVYEH + D+ IA+L + + T+TV K+FA TGWR+G Sbjct: 187 DFVVEHDLIVISDEVYEHFIYDDARHYSIASLDG-MFERTITVNGFSKTFAMTGWRLGFV 245 Query: 282 ----WVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKF 337 W++ + Y A + F +Q A A ++ D E+MR+EY + Sbjct: 246 AAPSWIIERMVKFQMY--NATCPVTF-----IQYAAAKALKDERSWKAVEEMRKEYDRRR 298 Query: 338 KIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELG 397 K+ +E+GLP P+G +++ +P + K F S ++ E Sbjct: 299 KLVWKRLNEMGLPTVKPKGAFYI------------FPRIRDTGLTSKKF--SELMLKEAR 344 Query: 398 VVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERL-KLLKD 442 V +P + F KA E +R + LE A++R+ ++LK+ Sbjct: 345 VAVVPGSAF-----GKAGEGYVRISYATAYEKLEEAMDRMERVLKE 385 >1O4S-A nrPDB Length = 389 Score = 152 bits (385), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 123/412 (29%), Positives = 196/412 (47%), Gaps = 52/412 (12%) Query: 36 SLTNEAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRP 95 S T E AKA K +G ++INL G + P+ ++EA + L V +Y+ RG Sbjct: 24 SKTMELDAKAKALIK-KGEDVINLTAGEPDFPTPEPVVEEAVRFLQKGEV-KYTDPRGIY 81 Query: 96 SLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPN 155 L + K Y ++ + V VT GA + + + M LL+ GDEVIVF P + YIP Sbjct: 82 ELREGIAKRIGERYKKDISPDQVVVTNGAKQALFNAFMALLDPGDEVIVFSPVWVSYIPQ 141 Query: 156 IELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVF 215 I L GG V N + +N + E+ E + KTKAV+IN+P+NP G V+ Sbjct: 142 IILAGGTV-----NVVETFMSKN-----FQPSLEEVEGLLVGKTKAVLINSPNNPTGVVY 191 Query: 216 TREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAA 275 RE L L + K N IISDEVY+ L +TD FT I +S ++ G + KS + Sbjct: 192 RREFLEGLVRLAKKRNFYIISDEVYDSLVYTDEFTSILDVSEGFDRIVYINGFS-KSHSM 250 Query: 276 TGWRIGWVLSLNAELLSYAA---KAHTRICFASPSPLQEACANSINDALKIGYFEKMRQE 332 TGWR+G+++S +E ++ A ++HT C + + A ++++ + F++ + Sbjct: 251 TGWRVGYLIS--SEKVATAVSKIQSHTTSCINTVAQYAALKALEVDNSYMVQTFKERKNF 308 Query: 333 YINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWL 392 + + K ++G+ + PEG +++ F KV +G D + L Sbjct: 309 VVERLK-------KMGVKFVEPEGAFYL---FFKV--------------RGDDVKFCERL 344 Query: 393 INELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLKDYL 444 + E V +P + F K L FA +E E L ++D+L Sbjct: 345 LEEKKVALVPGSAFL-----KPGFVRLSFATS-----IERLTEALDRIEDFL 386 >6F77-B nrPDB Length = 400 Score = 139 bits (351), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 109/402 (27%), Positives = 190/402 (47%), Gaps = 30/402 (7%) Query: 41 AAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINS 100 A ++ A K +GR++I LG G + P K A A+D +Y+P G P L + Sbjct: 18 AVSQKARELKAKGRDVIGLGAGEPDFDTPDNIKKAAIDAIDRGE-TKYTPVSGIPELREA 76 Query: 101 LIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCG 160 + K + N + A V TG + + + M LN GDEV++ P++ Y + LCG Sbjct: 77 IAKKFKRENNLDYTAAQTIVGTGGKQILFNAFMATLNPGDEVVIPAPYWVSYPEMVALCG 136 Query: 161 GKVVYVPINPPKELDQRNTRGE-EWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREE 219 G V+VP TR E + + E ++AIT KTK + N+P NP G ++ EE Sbjct: 137 GTPVFVP-----------TRQENNFKLKAEDLDRAITPKTKWFVFNSPSNPSGAAYSHEE 185 Query: 220 LTTLGNICVKH-NVVIISDEVYEHLYFTD-SFTRIATLSPEIGQLTLTVGSAGKSFAATG 277 L L ++ +KH +V +++D++YEHL + D F + P + + TLT+ K++A TG Sbjct: 186 LKALTDVLMKHPHVWVLTDDMYEHLTYGDFRFATPVEVEPGLYERTLTMNGVSKAYAMTG 245 Query: 278 WRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKF 337 WRIG+ L+ + + S Q A ++N + + ++ + + Sbjct: 246 WRIGYAAG-PLHLIKAMDMIQGQQTSGAASIAQWAAVEALNGPQD--FIGRNKEIFQGRR 302 Query: 338 KIFTSIFDEL-GLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINEL 396 + S+ ++ G+ PEG ++V + + I + P +++ +DF +S L E Sbjct: 303 DLVVSMLNQAKGISCPTPEGAFYVYPSCAGL-IGKTAP-SGKVIETDEDF-VSELLETE- 358 Query: 397 GVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLK 438 GV + + F + + R + +A LE A R++ Sbjct: 359 GVAVVHGSAFGLGPN-------FRISYATSEALLEEACRRIQ 393 >4MY5-A nrPDB Length = 393 Score = 122 bits (307), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 107/403 (26%), Positives = 185/403 (45%), Gaps = 60/403 (14%) Query: 55 ELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELK 114 +++ L G ++ P+ + A++A+D + Y+ G +L + Y+ Sbjct: 33 DVLKLTLGEPDFATPKHIKEAAKRAIDADE-SHYTGMAGLLALRQAASAFVKEKYHLTYN 91 Query: 115 AEN-VTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKE 173 +N + VT GA E + + L +L GD+V++ P + Y P + L G +VV + Sbjct: 92 PDNEILVTIGATEALSASLTAILEPGDKVLLPAPAYPGYEPVVNLVGAEVVEI------- 144 Query: 174 LDQRNTRGEEWTIDFEQFEKAITSK---TKAVIINTPHNPIGKVFTREELTTLGNICVKH 230 +TR ++ + E E+AI + KAVI+N P NP G ++R+++ L + K+ Sbjct: 145 ----DTRSNDFVLTPEMLEEAILKEGEALKAVILNYPTNPTGVTYSRQQIKNLAEVLKKY 200 Query: 231 NVVIISDEVYEHLYFT-DSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLS---L 286 + +ISDEVY L +T +S IA P+ T+ + KS A TGWR+G + + L Sbjct: 201 PIFVISDEVYAELTYTGESHVSIAEYLPD---QTILISGLSKSHAMTGWRLGLIFAPAVL 257 Query: 287 NAELLSYAAKAHTRICFASPSPLQ----EACANSINDALKIGYFEKMRQEYINKFKIFTS 342 A+L+ K+H + A+ + +Q EA N +DAL M++EYI + Sbjct: 258 TAQLI----KSHQYLVTAATTSVQFAAIEALTNGKDDAL------PMKEEYIKRRDYIIE 307 Query: 343 IFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKD-FRISHWLINELGVVAI 401 + + P+G +++ KIP + +G+D F+ E V I Sbjct: 308 KMEAMKFKIIKPDGAFYIF-----AKIP---------VAQGQDSFKFLQDFAKEKAVAFI 353 Query: 402 PPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLKDYL 444 P F K E LR + A +E E +K LK+++ Sbjct: 354 PGVAF-----GKYGEGYLRISYA---ASMETIKEAMKRLKEFM 388 >6F35-A nrPDB Length = 410 Score = 119 bits (299), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 100/403 (24%), Positives = 180/403 (44%), Gaps = 38/403 (9%) Query: 50 KNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIY 109 K +G+ +I LG G + P+ + A A+ +Y+ G P L ++ + + Sbjct: 37 KREGKPVIILGAGEPDFDTPEHVKQAASDAIHRGE-TKYTALDGTPELKKAIREKFQREN 95 Query: 110 NTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPIN 169 + + +TV TGA + + + +M L+ GDEVI+ P++ Y + +C GK V + + Sbjct: 96 GLAYELDEITVATGAKQILFNAMMASLDPGDEVIIPTPYWTSYSDIVHICEGKPVLIACD 155 Query: 170 PPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVK 229 + + E+ E AIT +T+ V++N+P NP G ++ + L + ++ Sbjct: 156 A----------SSGFRLTAEKLEAAITPRTRWVLLNSPSNPSGAAYSAADYRPLLEVLLR 205 Query: 230 H-NVVIISDEVYEHLYFTD-SFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLN 287 H +V ++ D++YEH+ + F A L P + TLTV K++A TGWRIG+ Sbjct: 206 HPHVWLLVDDMYEHIVYDGFRFVTPAQLEPGLKNRTLTVNGVSKAYAMTGWRIGYAGGPR 265 Query: 288 AELLSYAAKAHTRICFASPSPLQEACA----NSINDALK--IGYFEKMRQEYINKFKIFT 341 EL+ A ++ + PS + +A + N D LK F++ R +N Sbjct: 266 -ELIKAMAVVQSQAT-SCPSSISQAASVVALNGPQDFLKERTESFQRRRDLVVNGLNAID 323 Query: 342 SIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAI 401 GL PEG ++ + V + + P + I D +L+ + V + Sbjct: 324 ------GLDCRVPEGAFYTFSGCAGV-LGKVTPSGKRIKT---DTDFCAYLLEDAHVAVV 373 Query: 402 PPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLKDYL 444 P + F + R + +A L+ A+ER+ D L Sbjct: 374 PGSAFGLSP-------FFRISYATSEAELKEALERIAAACDRL 409 >1J32-A nrPDB Length = 388 Score = 119 bits (297), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 99/410 (24%), Positives = 185/410 (45%), Gaps = 50/410 (12%) Query: 36 SLTNEAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRP 95 +L +A AKA K +G ++ + G ++ P+ ++ A+ AL+ +Y P G P Sbjct: 15 TLIIDAKAKAM---KAEGIDVCSFSAGEPDFNTPKHIVEAAKAALEQGK-TRYGPAAGEP 70 Query: 96 SLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPN 155 L ++ + A+N+ VT G + I + ++ ++ GDEVI+ PF+ Y Sbjct: 71 RLREAIAQKLQRDNGLCYGADNILVTNGGKQSIFNLMLAMIEPGDEVIIPAPFWVSYPEM 130 Query: 156 IELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVF 215 ++L G V +P T ++ + EQ +AIT KTK ++ NTP NP G V+ Sbjct: 131 VKLAEGTPVILP----------TTVETQFKVSPEQIRQAITPKTKLLVFNTPSNPTGMVY 180 Query: 216 TREELTTLGNICVKHNVVIISDEVYEHLYFTDS-FTRIATLSPEIGQLTLTVGSAGKSFA 274 T +E+ + + V+ + ++SDE+YE + + D+ I SPE + ++ K++A Sbjct: 181 TPDEVRAIAQVAVEAGLWVLSDEIYEKILYDDAQHLSIGAASPEAYERSVVCSGFAKTYA 240 Query: 275 ATGWRIGWVLSLNAELLSYAAK----AHTRICFASPSPLQEACANSINDALK--IGYFEK 328 TGWR+G+ L+ L+ A K + + +C + A NS D ++ + F + Sbjct: 241 MTGWRVGF-LAGPVPLVKAATKIQGHSTSNVCTFAQYGAIAAYENS-QDCVQEMLAAFAE 298 Query: 329 MRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRI 388 R+ ++ GL P+G +++ +K DF Sbjct: 299 RRRYMLDALNAMP------GLECPKPDGAFYMFPSIAKTG------------RSSLDF-- 338 Query: 389 SHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLK 438 L+++ V +P F A++ +R + D ++ +ERL+ Sbjct: 339 CSELLDQHQVATVPGAAF-------GADDCIRLSYATDLDTIKRGMERLE 381 >2GB3-A nrPDB Length = 409 Score = 116 bits (291), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 83/280 (29%), Positives = 135/280 (48%), Gaps = 20/280 (7%) Query: 83 PMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEV 142 P V YS + G L + Y ++K ENV VT G +E IL + N GDE+ Sbjct: 70 PEVVYYSHSAGIWELREAFASYYKRRQRVDVKPENVLVTNGGSEAILFSFAVIANPGDEI 129 Query: 143 IVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAV 202 +V EPF+ Y ++ G K++ V R EE + E I +TK + Sbjct: 130 LVLEPFYANYNAFAKIAGVKLIPV-----------TRRMEEGFAIPQNLESFINERTKGI 178 Query: 203 IINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQL 262 +++ P NP G V+ ++E+ L I +H + +I DEVY + F F + LS E ++ Sbjct: 179 VLSNPCNPTGVVYGKDEMRYLVEIAERHGLFLIVDEVYSEIVFRGEFA--SALSIESDKV 236 Query: 263 TLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAK-AHTRICFASPSPLQEACANSINDAL 321 + + S K F+A G R+G +++ N EL+S+A K A R+ PL E + L Sbjct: 237 -VVIDSVSKKFSACGARVGCLITRNEELISHAMKLAQGRLA----PPLLEQIGSVGLLNL 291 Query: 322 KIGYFEKMRQEYINKFKIFTSIFDELGLP-YTAPEGTYFV 360 +F+ +R+ Y + + +E GL +T P G +++ Sbjct: 292 DDSFFDFVRETYRERVETVLKKLEEHGLKRFTKPSGAFYI 331 >2Z61-A nrPDB Length = 370 Score = 107 bits (267), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 96/393 (24%), Positives = 177/393 (45%), Gaps = 48/393 (12%) Query: 46 ANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLY 105 A +++G+++I+L G ++ P+ + E K+L Y+ +RG L + +LY Sbjct: 21 AQKLESEGKKVIHLEIGEPDFNTPKPIVDEGIKSLK-EGKTHYTDSRGILELREKISELY 79 Query: 106 SPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVY 165 Y ++ +N+ +T G++ G+ L +++ GDEV++ P + Y I G K V+ Sbjct: 80 KDKYKADIIPDNIIITGGSSLGLFFALSSIIDDGDEVLIQNPCYPCYKNFIRFLGAKPVF 139 Query: 166 VPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGN 225 ++T+ E E+A++ KTKA+IIN+P NP+G+V RE + Sbjct: 140 C----------------DFTV--ESLEEALSDKTKAIIINSPSNPLGEVIDRE----IYE 177 Query: 226 ICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLS 285 ++ IISDE+Y L + + + T+ + K +A TGWRIG+V+S Sbjct: 178 FAYENIPYIISDEIYNGLVYEGKCYSAIEFDENL-EKTILINGFSKLYAMTGWRIGYVIS 236 Query: 286 LNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFD 345 N E++ K + ++P+ Q A + + M +E+ + ++ Sbjct: 237 -NDEIIEAILKLQQNLFISAPTISQYAALKAFEKETE-REINSMIKEFDRRRRLVLKYVK 294 Query: 346 ELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTE 405 + G P G Y+V + I ED G++F ++ L+ E V P Sbjct: 295 DFGWEVNNPIGAYYVFPN-----IGED----------GREF--AYKLLKEKFVALTPGIG 337 Query: 406 FYIKEHEKAAENLLRFAVCKDDAYLENAVERLK 438 F K +N +R + ++ +ER+K Sbjct: 338 FGSK-----GKNYIRISYANSYENIKEGLERIK 365 >3DYD-A nrPDB Length = 427 Score = 107 bits (266), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 83/278 (29%), Positives = 125/278 (44%), Gaps = 34/278 (12%) Query: 23 NKYFTSNTAKDVWSLTNEAAAKAANN-----------SKNQGRELINLGQG---FFSYSP 68 N YF S +WS+ AK N N + +I+L G F P Sbjct: 17 NLYFQS-----MWSVRPSDMAKKTFNPIRAIVDNMKVKPNPNKTMISLSIGDPTVFGNLP 71 Query: 69 PQFAIKEAQK-ALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEG 127 + +A K ALD N Y+P+ G S + Y L+A++V +T+G ++ Sbjct: 72 TDPEVTQAMKDALDSGKYNGYAPSIGFLSSREEIASYYH-CPEAPLEAKDVILTSGCSQA 130 Query: 128 ILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTID 187 I CL L N G ++V P F Y E G +V + P K W ID Sbjct: 131 IDLCLAVLANPGQNILVPRPGFSLYKTLAESMGIEVKLYNLLPEKS----------WEID 180 Query: 188 FEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTD 247 +Q E I KT +I+N P NP G VF++ L + + + V I++DE+Y + F+D Sbjct: 181 LKQLEYLIDEKTACLIVNNPSNPCGSVFSKRHLQKILAVAARQCVPILADEIYGDMVFSD 240 Query: 248 S-FTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVL 284 + +ATLS ++ L+ G K + GWR+GW+L Sbjct: 241 CKYEPLATLSTDVP--ILSCGGLAKRWLVPGWRLGWIL 276 >4CVQ-A nrPDB Length = 431 Score = 106 bits (264), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 81/345 (23%), Positives = 156/345 (45%), Gaps = 35/345 (10%) Query: 44 KAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKAL-----DIPMVNQYSPTRGRPSLI 98 K A + +G +++ L G +P F + L ++P Y ++G S Sbjct: 49 KEAKRLEEEGNKVLKLNIG----NPAPFGFDAPDEILVDVIRNLPTAQGYCDSKGLYSAR 104 Query: 99 NSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIEL 158 ++++ Y ++ E++ + G +E I+ + LLN+GDE++V P + + + L Sbjct: 105 KAIMQHYQARGMRDVTVEDIYIGNGVSELIVQAMQALLNSGDEMLVPAPDYPLWTAAVSL 164 Query: 159 CGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTRE 218 GK V+ + +W D + IT +T+ ++I P+NP G V+++E Sbjct: 165 SSGKAVHYLCD----------ESSDWFPDLDDIRAKITPRTRGIVIINPNNPTGAVYSKE 214 Query: 219 ELTTLGNICVKHNVVIISDEVYEHLYFTDS-FTRIATLSPEIGQLTLTVGSAGKSFAATG 277 L + I +HN++I +DE+Y+ + + D+ IA L+P++ LT+T K++ G Sbjct: 215 LLMEIVEIARQHNLIIFADEIYDKILYDDAEHHSIAPLAPDL--LTITFNGLSKTYRVAG 272 Query: 278 WRIGWVLSLNAE-------LLSYAAKAHTRICFASPSPLQEACANSINDALKIGYF-EKM 329 +R GW++ LN + A R+C P+ Q A ++ I F Sbjct: 273 FRQGWMV-LNGPKKHAKGYIEGLEMLASMRLCANVPA--QHAIQTALGGYQSISEFITPG 329 Query: 330 RQEYINKFKIFTSIFDELGLPYTAPEGTYFVL--VDFSKVKIPED 372 + Y + + + I D G+ P G ++ +D + I +D Sbjct: 330 GRLYEQRNRAWELINDIPGVSCVKPRGALYMFPKIDAKRFNIHDD 374 >1XI9-A nrPDB Length = 406 Score = 106 bits (264), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 81/343 (23%), Positives = 152/343 (44%), Gaps = 48/343 (13%) Query: 46 ANNSKNQGRELINLGQG---FFSYSPPQF-------AIKEAQKALDIPMVNQYSPTRGRP 95 A + +G ++I L G F + PP+ AIKE N Y + G P Sbjct: 30 ARELEKKGIKVIRLNIGDPVKFDFQPPEHMKEAYCKAIKEGH--------NYYGDSEGLP 81 Query: 96 SLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPN 155 L ++++ ++ ++V VT E + LL+ GDE++V P + Y Sbjct: 82 ELRKAIVEREKRKNGVDITPDDVRVTAAVTEALQLIFGALLDPGDEILVPGPSYPPYTGL 141 Query: 156 IELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVF 215 ++ GGK V + R E+W D + K IT +TKA+ + P+NP G ++ Sbjct: 142 VKFYGGKPV----------EYRTIEEEDWQPDIDDIRKKITDRTKAIAVINPNNPTGALY 191 Query: 216 TREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAA 275 ++ L + NI ++ + +ISDE+Y+ + + +L+ ++ + + K + A Sbjct: 192 DKKTLEEILNIAGEYEIPVISDEIYDLMTYEGEHISPGSLTKDVP--VIVMNGLSKVYFA 249 Query: 276 TGWRIGWVLSLNAE----LLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQ 331 TGWR+G++ ++ E + A RI +P Q A + + + Sbjct: 250 TGWRLGYMYFVDPENKLSEVREAIDRLARIRLCPNTPAQFAAIAGLTGPM------DYLK 303 Query: 332 EYINKFK-----IFTSIFDELGLPYTAPEGTYFVLVDFSKVKI 369 EY+ K K I+ + + G+ T P+G +++ F K+++ Sbjct: 304 EYMKKLKERRDYIYKRLNEIPGISTTKPQGAFYI---FPKIEV 343 >4IX8-A nrPDB Length = 444 Score = 106 bits (264), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 91/365 (24%), Positives = 155/365 (42%), Gaps = 45/365 (12%) Query: 86 NQYSPTRGRPSLINSLIKLYSPIYNTE-----LKAENVTVTTGANEGILSCLMGLLNAGD 140 N Y PT G +L + + T+ LK ENV +T+G ++ I+ L L N GD Sbjct: 103 NGYPPTVGADNLRQVVSTYWRRFCQTKSRQEALKWENVIITSGVSQAIVLALTALCNEGD 162 Query: 141 EVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTK 200 ++V P F Y + G + Y ++P K W D + S TK Sbjct: 163 NILVCAPSFPHYKSVCDSYGIECRYYYLDPSKS----------WECDLRAAAGMVDSHTK 212 Query: 201 AVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDS-FTRIATLSPEI 259 A +I P NP G F+R ++ + + C +H + +ISDE+Y + + FT +A + Sbjct: 213 AFVIINPSNPCGSNFSRAHVSDIIDFCQQHQIPLISDEIYAEMVLNNGIFTSVADFDTNV 272 Query: 260 GQLTLTVGSAGKSFAATGWRIGWVLSLN----AELLSYAAKAHTRICFASPSPLQEACAN 315 +L L G K GWR+GW + ++ A + + T++ S QEA A Sbjct: 273 PRLIL--GGTAKYQVCPGWRVGWSILIDPMNVAGDWAVGMERLTQLIAGVNSICQEAIAR 330 Query: 316 SINDALKI--GYFEKMRQEYINKFKIFTSIFD-ELGLPYTAPEGTYFVLVDFSKVKIPED 372 ++ LK E + + K++ + + ++G+ AP+ + FV++ + Sbjct: 331 TL---LKCPTECTEHIVTQLEAGAKVYARLLEHDIGISMEAPQASMFVMLKL-------N 380 Query: 373 YPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLEN 432 Y +++ D L++E V +P F LR V + A L Sbjct: 381 LSYFQDL---KSDMEFYEKLLDEENVQVLPGEIF-------GMSGFLRATVSRPSAVLNE 430 Query: 433 AVERL 437 AV+R+ Sbjct: 431 AVDRI 435 >5WMH-A nrPDB Length = 475 Score = 105 bits (262), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 77/327 (23%), Positives = 156/327 (47%), Gaps = 27/327 (8%) Query: 116 ENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELD 175 + + V+ GA + +L ++ + + GDEVI+ P++ Y L V +P Sbjct: 160 DQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVVIP-------- 211 Query: 176 QRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKH-NVVI 234 + +D + E +T K++ +I+ +P NP G V+ + L + I KH +++ Sbjct: 212 --TKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIARIIAKHPRLLV 269 Query: 235 ISDEVYEHL-YFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSY 293 +SDE+YEH+ Y + T A+L P++ + TLTV K+FA TGWR+G+ L+ +++ Sbjct: 270 LSDEIYEHIIYAPATHTSFASL-PDMYERTLTVNGFSKAFAMTGWRLGY-LAGPKHIVAA 327 Query: 294 AAKAHTRICFASPSPLQEACANSINDALKIG-YFEKMRQEYINKFK-IFTSIFDELGLPY 351 +K ++ + S Q+A ++ G +M + Y + + S+ D G+ Sbjct: 328 CSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKSLGDIKGVKI 387 Query: 352 TAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEH 411 + P+G +++ +DFS E + ++N + + +++ V +P F Sbjct: 388 SEPQGAFYLFIDFSAYYGSEAEGF--GLINDSSSLAL--YFLDKFQVAMVPGDAF----- 438 Query: 412 EKAAENLLRFAVCKDDAYLENAVERLK 438 ++ +R + L+ AVE+++ Sbjct: 439 --GDDSCIRISYATSLDVLQAAVEKIR 463 >3PDX-A nrPDB Length = 402 Score = 103 bits (257), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 78/273 (28%), Positives = 125/273 (45%), Gaps = 28/273 (10%) Query: 17 RPKVVANKYFTSNTAKDVWSLTNEAAAKAANNSKNQGRELINLGQG---FFSYSPPQFAI 73 RP ++NK F + ++ + K N + +I+L G F P + Sbjct: 4 RPSDMSNKTFNP-----IRAIVDNMKVKP-----NPNKTVISLSIGDPTVFGNLPTDPEV 53 Query: 74 KEAQK-ALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCL 132 +A K ALD N Y+P+ G S + Y L+A++V +T+G ++ I CL Sbjct: 54 TQAMKDALDSGKYNGYAPSIGYLSSREEVASYYH-CPEAPLEAKDVILTSGCSQAIELCL 112 Query: 133 MGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFE 192 L N G +++ P F Y E G +V + P K W ID +Q E Sbjct: 113 AVLANPGQNILIPRPGFSLYRTLAESMGIEVKLYNLLPEKS----------WEIDLKQLE 162 Query: 193 KAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDS-FTR 251 I KT +++N P NP G VF++ L + + + V I++DE+Y + F+D + Sbjct: 163 SLIDEKTACLVVNNPSNPCGSVFSKRHLQKILAVAERQCVPILADEIYGDMVFSDCKYEP 222 Query: 252 IATLSPEIGQLTLTVGSAGKSFAATGWRIGWVL 284 +ATLS + L+ G K + GWR+GW+L Sbjct: 223 MATLSTNVP--ILSCGGLAKRWLVPGWRLGWIL 253 >3T32-A nrPDB Length = 383 Score = 97.1 bits (240), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 87/337 (25%), Positives = 156/337 (46%), Gaps = 42/337 (12%) Query: 52 QGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNT 111 + ELI+ + PQ +K ++ P+ P +I + K YN Sbjct: 22 KNEELIHAWIADMDFEVPQPIQTALKKRIEHPIFGYTLPPENIGDIICNWTKKQ---YNW 78 Query: 112 ELKAENVTVTTGANEGILSCLMGLLNAGDEVIV----FEPFFDQYIPN-IELCGGKVVYV 166 +++ E + + G + + + + V+V + PFF+ N +LC Sbjct: 79 DIQKEWIVFSAGIVPALSTSIQAFTKENESVLVQPPIYPPFFEMVTTNNRQLC------- 131 Query: 167 PINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNI 226 ++P L ++N + + IDFE EK K +++ +PHNPIG+V+ +EELT LG++ Sbjct: 132 -VSP---LQKQN---DTYAIDFEHLEKQFQQGVKLMLLCSPHNPIGRVWKKEELTKLGSL 184 Query: 227 CVKHNVVIISDEVYEHLYFTD-SFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLS 285 C K+NV++++DE++ + + D + T A+LS E+ T+T + K+F G + ++ Sbjct: 185 CTKYNVIVVADEIHSDIIYADHTHTPFASLSEELAARTITCMAPSKTFNIAGLQASIIII 244 Query: 286 LNAEL------LSYAAKAHTRICFASPSPLQEA---CANSIND-ALKIGYFEKMRQEYIN 335 N +L + Y H FA + +Q A C + +N+ I K EYI Sbjct: 245 PNEKLRQAFTSIQYRQGFHGLNIFAY-TAMQSAYTECNDWLNEIRFYIEDNAKFACEYI- 302 Query: 336 KFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPED 372 K I T L PEG++ + +D S + + +D Sbjct: 303 KDHIPT-------LSVMKPEGSFLLWIDCSALNLSQD 332 >2O1B-A nrPDB Length = 404 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 89/391 (22%), Positives = 160/391 (40%), Gaps = 46/391 (11%) Query: 56 LINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKA 115 LIN+ G PQ I QKAL IP +Y G+ + +++ Y YN L Sbjct: 49 LINMAVGIPDGPTPQGIIDHFQKALTIPENQKYGAFHGKEAFKQAIVDFYQRQYNVTLDK 108 Query: 116 EN-VTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKEL 174 E+ V + G G+++ ++N GD V++ +P + Y+ + L GK V + + PP Sbjct: 109 EDEVCILYGTKNGLVAVPTCVINPGDYVLLPDPGYTDYLAGVLLADGKPVPLNLEPP--- 165 Query: 175 DQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVI 234 + D+ + + I KTK + + P+NP G T+E + I Sbjct: 166 --------HYLPDWSKVDSQIIDKTKLIYLTYPNNPTGSTATKEVFDEAIAKFKGTDTKI 217 Query: 235 ISDEVYEHLYFTDSFTRIATLSPEIGQ-LTLTVGSAGKSFAATGWRIGWVLSLNAELLSY 293 + D Y F I L+ E G+ + + + S K + +G+R+G+ + N +++ Sbjct: 218 VHDFAYGAFGFDAKNPSI--LASENGKDVAIEIYSLSKGYNMSGFRVGFAVG-NKDMIQA 274 Query: 294 AAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKI----FTSIFDELGL 349 K T LQ+A ++N +++ +E N FK F ++ + L Sbjct: 275 LKKYQTHTNAGMFGALQDAAIYALN------HYDDFLEEQSNVFKTRRDRFEAMLAKADL 328 Query: 350 PYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIK 409 P+ +G +V ++ P Y + +L+ E ++ P F Sbjct: 329 PFVHAKGGIYVWLE-----TPPGY----------DSEQFEQFLVQEKSILVAPGKPF--- 370 Query: 410 EHEKAAENLLRFAVCKDDAYLENAVERLKLL 440 + +R ++ DD L+ A RL L Sbjct: 371 --GENGNRYVRISLALDDQKLDEAAIRLTEL 399 >4DQ6-A nrPDB Length = 391 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 77/287 (26%), Positives = 140/287 (48%), Gaps = 22/287 (7%) Query: 94 RPSLIN-SLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQY 152 RP N S++ +N ++K+E + + G I + L A D++++ EP + + Sbjct: 68 RPDSYNESIVNWLYRRHNWKIKSEWLIYSPGVIPAISLLINELTKANDKIMIQEPVYSPF 127 Query: 153 IPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIG 212 ++ +++ I+P ++L+ N + +D+E E I K I+ PHNP+G Sbjct: 128 NSVVKNNNRELI---ISPLQKLENGN-----YIMDYEDIENKIKD-VKLFILCNPHNPVG 178 Query: 213 KVFTREELTTLGNICVKHNVVIISDEVYEHLYF-TDSFTRIATLSPEIGQLTLTVGSAGK 271 +V+T++EL LG+IC+KHNV IISDE++ + +A++S E + T+T + K Sbjct: 179 RVWTKDELKKLGDICLKHNVKIISDEIHSDIILKKHKHIPMASISKEFEKNTITCMAPTK 238 Query: 272 SFAATGWRIGWVLSLNAELLSYAAKAHTRI------CFASPSPLQEACANSINDALKIGY 325 +F G + +V+ + + A TRI CF+ + EA N+ L+ + Sbjct: 239 TFNIAGLQSSYVVLPDEKDYKLLDDAFTRIDIKRNNCFSLVA--TEASYNNGESWLE-SF 295 Query: 326 FEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPED 372 E + K +L + PEGTY + VDFS + + ++ Sbjct: 296 LEYLESNIDFAIKYINENMPKLKV--RKPEGTYLLWVDFSALGLSDE 340 >1BW0-A nrPDB Length = 416 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 79/319 (24%), Positives = 140/319 (43%), Gaps = 41/319 (12%) Query: 73 IKEAQKALDIPMVNQYSPTRGRPSLINSLIKLY--SPIYNTELKA----ENVTVTTGANE 126 IK+ ++A+D N Y PT G P ++ + S ++ ELK+ +NV + +G + Sbjct: 56 IKKLKEAIDSQECNGYFPTVGSPEAREAVATWWRNSFVHKEELKSTIVKDNVVLCSGGSH 115 Query: 127 GILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCG-GKVVYVPINPPKELDQRNTRGE-EW 184 GIL + + +AGD +V +P F Y + G G Y N R E +W Sbjct: 116 GILMAITAICDAGDYALVPQPGFPHYETVCKAYGIGMHFY------------NCRPENDW 163 Query: 185 TIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLY 244 D ++ + KTK +I+ P NP G F+R+ + + + + + + SDE+Y + Sbjct: 164 EADLDEIRRLKDDKTKLLIVTNPSNPCGSNFSRKHVEDIVRLAEELRLPLFSDEIYAGMV 223 Query: 245 FTD-----SFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNA--------ELL 291 F +FT +A + ++ L G K+ GWR+GW+L ++ E L Sbjct: 224 FKGKDPNATFTSVADFETTVPRVIL--GGTAKNLVVPGWRLGWLLYVDPHGNGPSFLEGL 281 Query: 292 SYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPY 351 C + L EA N+ + L K+ + + ++ I + +GL Sbjct: 282 KRVGMLVCGPCTVVQAALGEALLNTPQEHLD-QIVAKIEE---SAMYLYNHIGECIGLAP 337 Query: 352 TAPEGTYFVL--VDFSKVK 368 T P G +++ +D K + Sbjct: 338 TMPRGAMYLMSRIDLEKYR 356 >5YHV-A nrPDB Length = 394 Score = 91.7 bits (226), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 71/252 (28%), Positives = 113/252 (44%), Gaps = 22/252 (8%) Query: 33 DVWSLTNEAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTR 92 DVW AA + G +L+NL G S P+ A AL + + YS Sbjct: 24 DVW-------LAAAERQRTHG-DLVNLSAGQPSAGAPEPVRAAAAAALHLNQLG-YSVAL 74 Query: 93 GRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQY 152 G P L +++ Y + ++ + V +TTG++ G L + +AGD V + P + Y Sbjct: 75 GIPELRDAIAADYQRRHGITVEPDAVVITTGSSGGFLLAFLACFDAGDRVAMASPGYPCY 134 Query: 153 IPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIG 212 + G +VV +P P TR + Q I + V++ +P NP G Sbjct: 135 RNILSALGCEVVEIPCGP-------QTRFQP----TAQMLAEIDPPLRGVVVASPANPTG 183 Query: 213 KVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKS 272 V EEL + + C +V +ISDEVY L + + + + + + + V S K Sbjct: 184 TVIPPEELAAIASWCDASDVRLISDEVYHGLVYQGAPQ--TSCAWQTSRNAVVVNSFSKY 241 Query: 273 FAATGWRIGWVL 284 +A TGWR+GW+L Sbjct: 242 YAMTGWRLGWLL 253 >3H14-A nrPDB Length = 391 Score = 87.0 bits (214), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 90/400 (22%), Positives = 160/400 (40%), Gaps = 49/400 (12%) Query: 44 KAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIK 103 +AA ++ GR +I++ G P+ A++ K+L+ + Y+ G P+L + + Sbjct: 21 EAARRAEEAGRRIIHMEVGQPGTGAPRGAVEALAKSLETDALG-YTVALGLPALRQRIAR 79 Query: 104 LYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKV 163 LY Y +L V +T G++ G L L ++GD V + P + Y + G Sbjct: 80 LYGEWYGVDLDPGRVVITPGSSGGFLLAFTALFDSGDRVGIGAPGYPSYRQILRALGLVP 139 Query: 164 VYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTL 223 V +P P L + DF + A +++ +P NP G + + L Sbjct: 140 VDLPTAPENRL-------QPVPADFAGLDLA------GLMVASPANPTGTMLDHAAMGAL 186 Query: 224 GNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWV 283 ISDE+Y + + A + E+ + S K F+ TGWR+GW+ Sbjct: 187 IEAAQAQGASFISDEIYHGIEYEAK----AVTALELTDECYVINSFSKYFSMTGWRVGWM 242 Query: 284 LSLNAELLSYAAKAHTR-ICFASPSPLQEACANSINDALK--IGYFEKMRQEYINKF--K 338 + ++ A IC S + A + L+ + ++ R+ + + Sbjct: 243 VVPEDQVRVVERIAQNMFICAPHASQVAALAALDCDAELQANLDVYKANRKLMLERLPKA 302 Query: 339 IFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGV 398 FT I P+G ++V D S + + + EIL K GV Sbjct: 303 GFTRI--------APPDGAFYVYADVSDLT-DDSRAFAAEILEKA-------------GV 340 Query: 399 VAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLK 438 P +F + E+ A LRF+ + A +E ++RL+ Sbjct: 341 AVTPGLDF---DPERGA-GTLRFSYARATADIEEGLDRLE 376 >3B1C-A nrPDB Length = 392 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 74/325 (22%), Positives = 135/325 (41%), Gaps = 52/325 (16%) Query: 88 YSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEP 147 Y T L+ +++ + E++ G I + G+ V++ P Sbjct: 62 YGYTYASDELLQAVLDWEKSEHQYSFDKEDIVFVEGVVPAISIAIQAFTKEGEAVLINSP 121 Query: 148 FFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEE---WTIDFEQFEKAIT-SKTKAVI 203 + + ++ L K+V N+ EE + IDFEQ E I + K + Sbjct: 122 VYPPFARSVRLNNRKLV------------SNSLKEENGLFQIDFEQLENDIVENDVKLYL 169 Query: 204 INTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHL-YFTDSFTRIATLSPEIGQL 262 + PHNP G+V+ RE L +G++C KH+V+++SDE+++ L F T+SP+ Sbjct: 170 LCNPHNPGGRVWEREVLEQIGHLCQKHHVILVSDEIHQDLTLFGHEHVSFNTVSPDFKDF 229 Query: 263 TLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALK 322 L + SA K+F G + + + N L A H ++ N+ ++ Sbjct: 230 ALVLSSATKTFNIAGTKNSYAIIENPTLC--AQFKHQQL------------VNNHHEVSS 275 Query: 323 IGYFE-----KMRQEYINKFKIFTSIFDELGLPYTA----------PEGTYFVLVDFSKV 367 +GY + + ++ K + + Y A P+GTY + +DFS Sbjct: 276 LGYIATETAYRYGKPWLVALKAVLEENIQFAVEYFAQEAPRLKVMKPQGTYLIWLDFSDY 335 Query: 368 KIPED------YPYPEEILNKGKDF 386 + +D + + ILN+G D+ Sbjct: 336 GLTDDALFTLLHDQAKVILNRGSDY 360 >2X5D-A nrPDB Length = 412 Score = 85.1 bits (209), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 83/398 (20%), Positives = 165/398 (41%), Gaps = 41/398 (10%) Query: 49 SKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPI 108 ++ +G ++I+L G P +++ + YS +RG P L ++ Y Sbjct: 32 ARRRGEDIIDLSMGNPDGPTPPHIVEKLCTVAQREDTHGYSTSRGIPRLRRAISHWYRDR 91 Query: 109 YNTELKAEN-VTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVP 167 Y+ ++ E+ VT G+ EG+ ++ L+ GD ++V P + +I + G +V VP Sbjct: 92 YDVQIDPESEAIVTIGSKEGLAHLMLATLDHGDTILVPNPSYPIHIYGAVIAGAQVRSVP 151 Query: 168 INPPKELDQRNTRGEEWTIDFEQFEKAITS---KTKAVIINTPHNPIGKVFTREELTTLG 224 + P + F + E+AI K + +I+ P NP + + + Sbjct: 152 LVPGIDF-------------FNELERAIRESIPKPRMMILGFPSNPTAQCVELDFFERVV 198 Query: 225 NICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVL 284 + +++V+++ D Y + + P + + + KS+ GWRIG+++ Sbjct: 199 ALAKQYDVMVVHDLAYADIVYDGWKAPSIMQVPGAKDIAVEFFTLSKSYNMAGWRIGFMV 258 Query: 285 SLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIF 344 N EL+S A+ + + + +PLQ A ++ + + ++Y + + Sbjct: 259 G-NPELVSALARIKSYHDYGTFTPLQVAAIAALEGDQQC--VRDIARQYQQRRDVLVKGL 315 Query: 345 DELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPT 404 E G P+ + +V KIPE Y + + K L+ + V P Sbjct: 316 REAGWMVENPKASMYVW-----AKIPEPYAHLGSLEFAKK-------LLQDAKVSVSPGI 363 Query: 405 EF--YIKEHEKAAENLLRFAVCKDDAYLENAVERLKLL 440 F Y +H +RFA+ ++ L AV +K + Sbjct: 364 GFGDYGDDH-------VRFALIENRDRLRQAVRGIKAM 394 >3ELE-A nrPDB Length = 398 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 76/305 (24%), Positives = 131/305 (42%), Gaps = 38/305 (12%) Query: 73 IKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCL 132 IKE D ++ Y+ +G ++ + + + T A+N+ +T GA + C Sbjct: 57 IKELVTDYDSVALHGYTSAQGDVETRAAIAEFLNNTHGTHFNADNLYMTMGAAASLSICF 116 Query: 133 MGLL-NAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQF 191 L +A DE I P+F +Y + G ++V VP + E + IDF+ Sbjct: 117 RALTSDAYDEFITIAPYFPEYKVFVNAAGARLVEVPADT-----------EHFQIDFDAL 165 Query: 192 EKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHN------VVIISDEVYEHLYF 245 E+ I + T+ VIIN+P+NP G V++ E + L ++ K + + II+DE Y + + Sbjct: 166 EERINAHTRGVIINSPNNPSGTVYSEETIKKLSDLLEKKSKEIGRPIFIIADEPYREIVY 225 Query: 246 TDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLN-----AELLSY---AAKA 297 T + TL S KS + G RIG+VL + AEL + A +A Sbjct: 226 DGIKVPFVT---KYYDNTLVCYSYSKSLSLPGERIGYVLVPDEVYDKAELYAAVCGAGRA 282 Query: 298 HTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGT 357 +C +PS Q+ I +++ R + +G P+G Sbjct: 283 LGYVC--APSLFQKMIVKCQGATGDINAYKENRD-------LLYEGLTRIGYHCFKPDGA 333 Query: 358 YFVLV 362 +++ V Sbjct: 334 FYMFV 338 >3L8A-A nrPDB Length = 421 Score = 78.2 bits (191), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 66/261 (25%), Positives = 113/261 (43%), Gaps = 17/261 (6%) Query: 116 ENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELD 175 E++ G I L GD V++ P + + I L ++V L Sbjct: 120 EDILFIDGVVPAISIALQAFSEKGDAVLINSPVYYPFARTIRLNDHRLV------ENSLQ 173 Query: 176 QRNTRGEEWTIDFEQFEK-AITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVI 234 N R E IDFEQ EK I + K ++ +PHNP G+V+ ++L + +C KH V++ Sbjct: 174 IINGRFE---IDFEQLEKDIIDNNVKIYLLCSPHNPGGRVWDNDDLIKIAELCKKHGVIL 230 Query: 235 ISDEVYEHL-YFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSY 293 +SDE+++ L F ++ + TL T+ + SA K+F G + + + N L Sbjct: 231 VSDEIHQDLALFGNTHHSLNTLDASYKDFTIILSSATKTFNIAGTKNSFAIIQNESL--- 287 Query: 294 AAKAHTRICFASPSPLQEACANSINDALKIG--YFEKMRQEYINKFKIFTSIFD-ELGLP 350 K R + + + A + G + E+++ K+ + + + Sbjct: 288 RRKFQYRQLANNQHEVPTVGMIATQAAFQYGKPWLEELKTVIEGNIKLVIKELEAKTKIK 347 Query: 351 YTAPEGTYFVLVDFSKVKIPE 371 PEGTY V +DFS I + Sbjct: 348 VMEPEGTYLVWLDFSAYAIAQ 368 >2ZC0-A nrPDB Length = 407 Score = 74.7 bits (182), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 101/390 (25%), Positives = 152/390 (38%), Gaps = 48/390 (12%) Query: 44 KAANNSKNQGRELINLGQGFFSYSP---PQFAIKE-AQKALDI-PMVNQYSPTRGRPSLI 98 K A+ + +G +LI+L G P P+ + E A++ L+ P Y+P G P L Sbjct: 24 KKASELQKKGVKLISLAAG--DPDPELIPRAVLGEIAKEVLEKEPKSVMYTPANGIPELR 81 Query: 99 NSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIEL 158 L + E+ EN+ +T G + L++ GD VI P + + E Sbjct: 82 EELAAFLKKYDHLEVSPENIVITIGGTGALDLLGRVLIDPGDVVITENPSYINTLLAFEQ 141 Query: 159 CGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAV-IINTPHNPIGKVFTR 217 G K+ VP+ D R + ++ KA K K + I T NP+G + Sbjct: 142 LGAKIEGVPV------DNDGMRVDLLEEKIKEL-KAKGQKVKLIYTIPTGQNPMGVTMSM 194 Query: 218 EELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATG 277 E L I K++++II D Y + + I L + + V TG Sbjct: 195 ERRKALLEIASKYDLLIIEDTAYNFMRYEGG--DIVPLKALDNEGRVIVAGTLSKVLGTG 252 Query: 278 WRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQE----- 332 +RIGW+++ E+L I F +P+ Q + LK GYFEK E Sbjct: 253 FRIGWIIA-EGEILKKVLMQKQPIDFCAPAISQYIAL----EYLKRGYFEKYHLEGALLG 307 Query: 333 YINKFKIFTSIFDELGLP---YTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKD-FRI 388 Y K I E LP +T P FV+ L +G D Sbjct: 308 YKEKRDIMLKAL-ENHLPNAEFTKPIAGMFVMF----------------FLPEGADGISF 350 Query: 389 SHWLINELGVVAIPPTEFYIKEHEKAAENL 418 ++ L+ GVV +P FY E K A L Sbjct: 351 ANELMEREGVVVVPGKPFYTDESGKNAIRL 380 >1C7O-A nrPDB Length = 399 Score = 74.3 bits (181), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 78/367 (21%), Positives = 160/367 (43%), Gaps = 52/367 (14%) Query: 53 GRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTE 112 G E++ L + P I+ +K LD ++ PT + +K + + Sbjct: 30 GNEVVPLSVADMEFKNPPELIEGLKKYLDETVLGYTGPTEEYKKTVKKWMK---DRHQWD 86 Query: 113 LKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPK 172 ++ + + T G + + + GD VI+ P + + I+ K++ Sbjct: 87 IQTDWIINTAGVVPAVFNAVREFTKPGDGVIIITPVYYPFFMAIKNQERKIIEC------ 140 Query: 173 ELDQRNTRGEEWTIDFEQFEKAITSKT-KAVIINTPHNPIGKVFTREELTTLGNICVKHN 231 EL +++ +TIDF++ EK K KA++ +PHNP+G+V+ ++EL + +I +K + Sbjct: 141 ELLEKDGY---YTIDFQKLEKLSKDKNNKALLFCSPHNPVGRVWKKDELQKIKDIVLKSD 197 Query: 232 VVIISDEV--------YEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWV 283 +++ SDE+ YEH F ++ ++ T+T + K+F G + + Sbjct: 198 LMLWSDEIHFDLIMPGYEHTVF-------QSIDEQLADKTITFTAPSKTFNIAGMGMSNI 250 Query: 284 LSLNAELLSYAAKAH--------TRICFASPSPLQEACANSINDALKIGYFEKMRQEYIN 335 + N ++ K+ T + + + + C ++ +K+ I+ Sbjct: 251 IIKNPDIRERFTKSRDATSGMPFTTLGYKACEICYKECGKWLDGCIKV----------ID 300 Query: 336 KFKIFTSIFDELGLP-YTAP--EGTYFVLVDFSKVKIPEDYPYPEE-ILNKGKDFRISHW 391 K + F E+ P AP EGTY +DF +K+ D+ EE +++K + F + Sbjct: 301 KNQRIVKDFFEVNHPEIKAPLIEGTYLQWIDFRALKM--DHKAMEEFMIHKAQIFFDEGY 358 Query: 392 LINELGV 398 + + G+ Sbjct: 359 IFGDGGI 365 >3OP7-A nrPDB Length = 375 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 86/329 (26%), Positives = 128/329 (38%), Gaps = 57/329 (17%) Query: 88 YSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEP 147 Y G P+ S+ +LY T +K E + T GA L L L+ GD VI P Sbjct: 59 YGWIEGSPAFKKSVSQLY-----TGVKPEQILQTNGATGANLLVLYSLIEPGDHVISLYP 113 Query: 148 FFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEE-WTIDFEQFEKAITSKTKAVIINT 206 + Q + +P + E+D E W D E+ + I TK + IN Sbjct: 114 TYQQ-----------LYDIPKSLGAEVDLWQIEEENGWLPDLEKLRQLIRPTTKMICINN 162 Query: 207 PHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLS-PEIGQLTLT 265 +NP G V R L L I + I+SDEVY SF+ + S E+ + Sbjct: 163 ANNPTGAVMDRTYLEELVEIASEVGAYILSDEVYR------SFSELDVPSIIEVYDKGIA 216 Query: 266 VGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSIND---ALK 322 V S K+++ G RIGWV AA CA +D L Sbjct: 217 VNSLSKTYSLPGIRIGWV----------AANHQVTDILRDYRDYTMICAGVFDDLVAQLA 266 Query: 323 IGYFEKMRQEYINKFKIFTSIFD-----ELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPE 377 + +++++ + + + +I D E + Y P +V S VKI D P Sbjct: 267 LAHYQEILERNRHILEENLAILDQWIEEEPLVSYIRP-----AVVSTSFVKIAVDMPM-- 319 Query: 378 EILNKGKDFRISHWLINELGVVAIPPTEF 406 +DF + L+ E GV+ +P F Sbjct: 320 ------EDFCLQ--LLQEHGVLLVPGNRF 340 >3DZZ-A nrPDB Length = 391 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 43/161 (26%), Positives = 77/161 (47%), Gaps = 9/161 (5%) Query: 114 KAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKE 173 K + +G I + + + GD+++V EP ++ + IE G +V+ + Sbjct: 84 KEDWCVFASGVVPAISAMVRQFTSPGDQILVQEPVYNMFYSVIEGNGRRVI------SSD 137 Query: 174 LDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVV 233 L N++ D E EK T + ++ PHNPIG ++ EE+ + +C KH V+ Sbjct: 138 LIYENSKYSVNWADLE--EKLATPSVRMMVFCNPHNPIGYAWSEEEVKRIAELCAKHQVL 195 Query: 234 IISDEVYEHLYFTD-SFTRIATLSPEIGQLTLTVGSAGKSF 273 +ISDE++ L TD T T+ + +++ S K+F Sbjct: 196 LISDEIHGDLVLTDEDITPAFTVDWDAKNWVVSLISPSKTF 236 >3F6T-A nrPDB Length = 533 Score = 65.1 bits (157), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 51/154 (33%), Positives = 75/154 (48%), Gaps = 15/154 (9%) Query: 135 LLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKA 194 LL GD++ + EP F Y+ EL ++V E+D + +W I+ + EK Sbjct: 189 LLKKGDKIAINEPIFTPYLRIPELKDYELV--------EVDLHSYEKNDWEIEPNEIEKL 240 Query: 195 ITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKH-NVVIISDEVYEHLYFTDSFTRIA 253 KA+I+ P NP K F L + K+ ++IISDEVY F +F I Sbjct: 241 KDPSIKALIVVNPTNPTSKEFDTNALNAIKQAVEKNPKLMIISDEVYGA--FVPNFKSIY 298 Query: 254 TLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLN 287 ++ P T+ V S K F TGWR+G V++LN Sbjct: 299 SVVP---YNTMLVYSYSKLFGCTGWRLG-VIALN 328 >2ZY3-A nrPDB Length = 546 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 50/154 (32%), Positives = 68/154 (44%), Gaps = 15/154 (9%) Query: 132 LMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQF 191 L GLL AGD+V + P F YI EL + V IN L+ W + Sbjct: 187 LNGLLKAGDKVAIGMPVFTPYIEIPELAQYALEEVAINADPSLN--------WQYPDSEL 238 Query: 192 EKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKH--NVVIISDEVYEHLYFTDSF 249 +K K P NP + L + NI +H +++I++D+VY F D F Sbjct: 239 DKLKDPAIKIFFCVNPSNPPSVKMDQRSLERVRNIVAEHRPDLMILTDDVYGT--FADDF 296 Query: 250 TRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWV 283 + + PE TL V S K F ATGWR+G V Sbjct: 297 QSLFAICPEN---TLLVYSFSKYFGATGWRLGVV 327 >4M2J-A nrPDB Length = 406 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 68/256 (26%), Positives = 107/256 (41%), Gaps = 18/256 (7%) Query: 115 AENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKEL 174 A+ V VT G++E I L LL+ GD V+V E + G V +P Sbjct: 102 ADRVLVTHGSSEAIALTLNALLHRGDRVVVQEGIYHSLGHYPRAAGCDVAVLP------- 154 Query: 175 DQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVI 234 R R E ID + +T T AVI+N PHNP G + + L L V+ Sbjct: 155 -GRAVRDGE--IDPDVLAGLVTPGTAAVIVNFPHNPTGVTLSPQGLRALKERTAATGAVL 211 Query: 235 ISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYA 294 + D + + +A + G T++ G+ K+F G R+GW ++ ELL+ Sbjct: 212 VWDAATAEI--AHRWEVLADPGADGGD-TVSYGTLSKTFGLPGLRVGWAVAPK-ELLTAT 267 Query: 295 AKAHTRICFASPSPLQEACA-NSINDALK-IGYFEKMRQEYINKFKIFTSIFDELGLPYT 352 R SPL E A ++ A + IG + + + + +EL + +T Sbjct: 268 FPLRDRTTLFL-SPLVELVAERAVRHADELIGARAAEARHNLAHLTGWMAAHEEL-VRWT 325 Query: 353 APEGTYFVLVDFSKVK 368 PEG L F +++ Sbjct: 326 PPEGGVCALPVFRELE 341 >5Z0Q-C nrPDB Length = 389 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 29/98 (29%), Positives = 51/98 (52%), Gaps = 2/98 (2%) Query: 182 EEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYE 241 + W +D + E ++ K +++ PHNP G V+ R+EL +H++++ SDE++ Sbjct: 149 QRWVLDLDSHEDRMSGNEKLLLLCNPHNPGGTVYRRKELEAQLRFAQRHDLLVCSDEIHC 208 Query: 242 HLYFTDSFTRI--ATLSPEIGQLTLTVGSAGKSFAATG 277 L I A+LS + Q ++T+ S KSF G Sbjct: 209 DLVLEPGVQHIPFASLSDDAAQRSITLMSPSKSFNIAG 246 >3EZS-A nrPDB Length = 376 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 71/306 (23%), Positives = 130/306 (42%), Gaps = 32/306 (10%) Query: 57 INLGQGFFSYSPPQF---AIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTEL 113 ++LG G + P+F A+K +L+I Y + SL + + + EL Sbjct: 26 LDLGIGEPQFETPKFIQDALKNHTHSLNI-----YPKSAFEESLRAAQRGFFKRRFKIEL 80 Query: 114 KAENVTVTTGANEGILSC-LMGLLNAGDEVIVF-EPFFDQYIPNIELCGGKVVYVPINPP 171 K + T G+ E + + L + + I + PF+ Y + K + +P+ Sbjct: 81 KENELISTLGSREVLFNFPSFVLFDYQNPTIAYPNPFYQIYEGAAKFIKAKSLLMPL--- 137 Query: 172 KELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHN 231 T+ ++T + E + VI+N+P+NP G+ + EEL + + +KH+ Sbjct: 138 -------TKENDFTPSLNEKE---LQEVDLVILNSPNNPTGRTLSLEELISWVKLALKHD 187 Query: 232 VVIISDEVYEHLYFTD---SFTRIATLSP-EIGQLTLTVGSAGKSFAATGWRIGWVLSLN 287 ++I+DE Y +Y S L+ E + L + S K +A G R G++ + Sbjct: 188 FILINDECYSEIYENTPPPSLLEACMLAGNEAFKNVLVIHSLSKRSSAPGLRSGFIAG-D 246 Query: 288 AELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIF-DE 346 + LL + + S + +Q+A + D +F R Y N K+ IF + Sbjct: 247 SRLLEKYKAFRAYLGYTSANAIQKASEAAWLDDRHAEFF---RNIYANNLKLARKIFKNT 303 Query: 347 LGLPYT 352 L PY+ Sbjct: 304 LIYPYS 309 >1D2F-A nrPDB Length = 390 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 30/108 (27%), Positives = 57/108 (52%), Gaps = 10/108 (9%) Query: 139 GDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITS- 197 G+ V++ P +D + IE G + +P+ K+ D W D + E + Sbjct: 111 GEGVVIHTPAYDAFYKAIE--GNQRTVMPVALEKQADG-------WFCDMGKLEAVLAKP 161 Query: 198 KTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYF 245 + K +++ +P NP GKV+T +EL + ++C +H V +ISDE++ + + Sbjct: 162 ECKIMLLCSPQNPTGKVWTCDELEIMADLCERHGVRVISDEIHMDMVW 209 >1IAY-A nrPDB Length = 428 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 51/185 (27%), Positives = 85/185 (45%), Gaps = 17/185 (9%) Query: 121 TTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTR 180 TGANE I+ CL + GD +V P++ + ++ G V +PI+ + + T Sbjct: 117 ATGANETIIFCLA---DPGDAFLVPSPYYPAFNRDLRWRTG-VQLIPIHCESSNNFKITS 172 Query: 181 GEEWTIDFEQFEKAITS--KTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDE 238 E +E A S K K +I+ P NP+G ++ L ++ + +HN+ ++ DE Sbjct: 173 KAVK----EAYENAQKSNIKVKGLILTNPSNPLGTTLDKDTLKSVLSFTNQHNIHLVCDE 228 Query: 239 VYEHLYF-TDSFTRIATLSPEI------GQLTLTVGSAGKSFAATGWRIGWVLSLNAELL 291 +Y F T F IA + E L V S K G+R+G + S N +++ Sbjct: 229 IYAATVFDTPQFVSIAEILDEQEMTYCNKDLVHIVYSLSKDMGLPGFRVGIIYSFNDDVV 288 Query: 292 SYAAK 296 + A K Sbjct: 289 NCARK 293 >3NRA-A nrPDB Length = 407 Score = 58.9 bits (141), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 63/329 (19%), Positives = 133/329 (40%), Gaps = 34/329 (10%) Query: 85 VNQYSPTRGRPSLINSLIKLYSPIYNTELKA-ENVTVTTGANEGILSCLMGLLNAGDEVI 143 V Y+ RG + + L + + A + + +T G + + + GD+V Sbjct: 71 VQAYTEYRGDLGIRDLLAPRLAAFTGAPVDARDGLIITPGTQGALFLAVAATVARGDKVA 130 Query: 144 VFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVI 203 + +P + +E G++V P +LD + +D E+A + + + Sbjct: 131 IVQPDYFANRKLVEFFEGEMV------PVQLDYVSADETRAGLDLTGLEEAFKAGARVFL 184 Query: 204 INTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHL-YFTDSFTRIATLSPEIGQL 262 + P+NP G V++ EE+ + + ++ +I+D++Y L Y S+T + + + Sbjct: 185 FSNPNNPAGVVYSAEEIGQIAALAARYGATVIADQLYSRLRYAGASYTHLRAEAAVDAEN 244 Query: 263 TLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDAL- 321 +T+ K+ + +G+R+G A +++ K + + Q ++A Sbjct: 245 VVTIMGPSKTESLSGYRLGVAFGSRA-IIARMEKLQAIVSLRAAGYSQAVLRGWFDEAPG 303 Query: 322 ----KIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPE 377 +I + +R E ++ + +F T G+Y ++P+ P Sbjct: 304 WMEDRIARHQAIRDELLHVLRGCEGVFAR-----TPQAGSYLF------PRLPKLAVAPA 352 Query: 378 EILNKGKDFRISHWLINELGVVAIPPTEF 406 E + K R+ + GVV P TEF Sbjct: 353 EFV---KILRL------QAGVVVTPGTEF 372 >3FDD-A nrPDB Length = 533 Score = 57.8 bits (138), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 47/152 (30%), Positives = 64/152 (42%), Gaps = 15/152 (9%) Query: 134 GLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEK 193 GLL AGD+V + P F YI EL + V IN L+ W + +K Sbjct: 189 GLLKAGDKVAIGMPVFTPYIEIPELAQYALEEVAINADPALN--------WQYPDSELDK 240 Query: 194 AITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKH--NVVIISDEVYEHLYFTDSFTR 251 K P NP L + I +H +++I++D+VY F D F Sbjct: 241 LKDPAIKIFFCVNPSNPPSVKMDERSLERVRKIVAEHRPDLMILTDDVYGT--FADGFQS 298 Query: 252 IATLSPEIGQLTLTVGSAGKSFAATGWRIGWV 283 + + P TL V S K F ATGWR+G V Sbjct: 299 LFAICPAN---TLLVYSFSKYFGATGWRLGVV 327 >2ZY2-A nrPDB Length = 544 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 47/163 (28%), Positives = 71/163 (43%), Gaps = 15/163 (9%) Query: 134 GLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEK 193 GLL AGD+V + P F YI EL + VPI+ D N W + +K Sbjct: 188 GLLKAGDKVAIGMPVFTPYIEIPELAQYDLKEVPIHA----DPDNG----WQYSDAELDK 239 Query: 194 AITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKH--NVVIISDEVYEHLYFTDSFTR 251 K P NP + L + I + +++I++D+VY F D F Sbjct: 240 LKDPDVKIFFCVNPSNPPSVKMDQRSLDRVRAIVAEQRPDLLILTDDVYGT--FADEFQS 297 Query: 252 IATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYA 294 + ++ P + TL V S K F ATGWR+G + + + +A Sbjct: 298 LFSVCP---RNTLLVYSFSKYFGATGWRLGVIAAHKDNVFDHA 337 >3G0T-A nrPDB Length = 437 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 59/263 (22%), Positives = 102/263 (38%), Gaps = 26/263 (9%) Query: 40 EAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLIN 99 + A N K G + + G PQ I+ + L + + Y G P L Sbjct: 30 DLVALVTNLEKATGTKFCRMEMGVPGLPAPQIGIETEIQKLREGVASIYPNLDGLPELKQ 89 Query: 100 SLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDE-------VIVFEPFFDQY 152 + N ++ A T G+ +G C + L A + +P F+ Sbjct: 90 EASRFAKLFVNIDIPARACVPTVGSMQG---CFVSFLVANRTHKNREYGTLFIDPGFNLN 146 Query: 153 IPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIG 212 + G K + D RGE+ E + + T + ++I + P+NP Sbjct: 147 KLQCRILGQKF--------ESFDLFEYRGEKLREKLESYLQ--TGQFCSIIYSNPNNPTW 196 Query: 213 KVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIAT--LSPEIGQLT---LTVG 267 + T EEL +G + KH+V++I D Y + F ++ P + T + Sbjct: 197 QCMTDEELRIIGELATKHDVIVIEDLAYFGMDFRKDYSHPGEPLYQPSVANYTDNYILAL 256 Query: 268 SAGKSFAATGWRIGWVLSLNAEL 290 S+ K+F+ G RIG VL ++ +L Sbjct: 257 SSSKAFSYAGQRIG-VLMISGKL 278 >3JTX-A nrPDB Length = 396 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 88/404 (21%), Positives = 159/404 (39%), Gaps = 52/404 (12%) Query: 49 SKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPI 108 S +G E + L G + P+ I +A A + + +Y T G P L + Sbjct: 25 SAPEGMEAVPLHIGEPKHPTPK-VITDALTA-SLHELEKYPLTAGLPELRQACANWLKRR 82 Query: 109 YNT-ELKAEN-VTVTTGANEGILSCLMGLLNAGDE-----VIVFEPFFDQYIPNIELCGG 161 Y+ + A+N + G+ E + S + +LN + ++ PF+ Y L GG Sbjct: 83 YDGLTVDADNEILPVLGSREALFSFVQTVLNPVSDGIKPAIVSPNPFYQIYEGATLLGGG 142 Query: 162 KVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELT 221 ++ + N + D+ + + +TK V + +P+NP G V + Sbjct: 143 EIHFA-----------NCPAPSFNPDWRSISEEVWKRTKLVFVCSPNNPSGSVLDLDGWK 191 Query: 222 TLGNICVKHNVVIISDEVYEHLYFTDSFTRIATL--SPEIG---QLTLTVGSAGKSFAAT 276 + ++ K+ +I SDE Y +YF D + L + ++G Q L S K Sbjct: 192 EVFDLQDKYGFIIASDECYSEIYF-DGNKPLGCLQAAAQLGRSRQKLLMFTSLSKRSNVP 250 Query: 277 GWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINK 336 G R G+V +AELL T A P+Q A + +D + ++ QE + Sbjct: 251 GLRSGFVAG-DAELLKNFLLYRTYHGSAMSIPVQRASIAAWDDEQHVIDNRRLYQEKFER 309 Query: 337 -FKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINE 395 I +FD P+ ++++ +K+P+ G D + L + Sbjct: 310 VIPILQQVFD-----VKLPDASFYIW-----LKVPD-----------GDDLAFARNLWQK 348 Query: 396 LGVVAIPPTEFYIKEHEKA--AENLLRFAVCKDDAYLENAVERL 437 + + P F ++ E+ E +R A+ D A A E + Sbjct: 349 -AAIQVLPGRFLARDTEQGNPGEGYVRIALVADVATCVKAAEDI 391 >2DOU-A nrPDB Length = 376 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 49/244 (20%), Positives = 97/244 (39%), Gaps = 16/244 (6%) Query: 44 KAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIK 103 +A ++ +G LI+L G PP+ +K +AL+ P Y + + Sbjct: 15 EAKRKARERGVGLIDLSIGSTDLPPPEAPLKALAEALNDPTTYGYCLKSCTLPFLEEAAR 74 Query: 104 LYSPIYNTELKAENVTVT-TGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGK 162 Y Y L + G+ EG+ L+ L D +++ E + Y + + Sbjct: 75 WYEGRYGVGLDPRREALALIGSQEGLAHLLLALTEPEDLLLLPEVAYPSYFGAARVASLR 134 Query: 163 VVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTT 222 +P+ E+ D + + + + K +++N P+NP G V Sbjct: 135 TFLIPLR------------EDGLADLKAVPEGVWREAKVLLLNYPNNPTGAVADWGYFEE 182 Query: 223 LGNICVKHNVVIISDEVY-EHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIG 281 + KH + +I D Y + +Y ++ + +A P + + + S KS+ G+R+G Sbjct: 183 ALGLARKHGLWLIHDNPYVDQVYEGEAPSPLAL--PGAKERVVELFSLSKSYNLAGFRLG 240 Query: 282 WVLS 285 + L Sbjct: 241 FALG 244 >4GDY-A nrPDB Length = 439 Score = 54.7 bits (130), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 58/226 (25%), Positives = 103/226 (45%), Gaps = 25/226 (11%) Query: 70 QFAIKEAQKALDIPMVNQYSPTRGRPSLINSL----IKLYSPI---YNTELKAENVTVTT 122 QF + ++AL QYSP+ G P L++ L IKL++P Y ++ VT+ Sbjct: 62 QFGEEMMKRAL------QYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTS 115 Query: 123 GANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINP----PKELDQRN 178 G+ +G+ ++N GD V++ EP + + ++ G ++ V + P L Sbjct: 116 GSQQGLCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDIL 175 Query: 179 TRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDE 238 +R W + + + T K + N +NP G T E + + K++ +II D+ Sbjct: 176 SR---WKPEDAKNPQKNTPKFLYTVPNG-NNPTGNSLTSERKKEIYELARKYDFLIIEDD 231 Query: 239 VYEHLYFTDSFTRIAT-LSPEIGQLTLTVGSAGKSFAATGWRIGWV 283 Y L F R+ T LS ++ + S K ++G RIG++ Sbjct: 232 PYYFLQFNSG--RVPTFLSMDVDGRVIRADSFSK-IISSGLRIGFL 274 >3TCM-A nrPDB Length = 500 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 46/174 (26%), Positives = 82/174 (47%), Gaps = 16/174 (9%) Query: 88 YSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLL--NAGDEVIVF 145 YS ++G L +++ + A+++ +T GA+ G+ +M LL N D ++V Sbjct: 130 YSHSQGIHGLRDAIASGIASRDGFPANADDIFLTDGASPGV-HLMMQLLIRNEKDGILVP 188 Query: 146 EPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITS--KTKAVI 203 P + Y +I L GG +V P L++ G E + +Q E A + +A++ Sbjct: 189 IPQYPLYSASIALHGGALV------PYYLNESTGWGLETSDVKKQLEDARSRGINVRALV 242 Query: 204 INTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTD-----SFTRI 252 + P NP G+V E + C +V+++DEVY+ + D SF +I Sbjct: 243 VINPGNPTGQVLAEENQYDIVKFCKNEGLVLLADEVYQENIYVDNKKFHSFKKI 296 >1IJI-A nrPDB Length = 356 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 53/220 (24%), Positives = 90/220 (40%), Gaps = 26/220 (11%) Query: 113 LKAENVTVTTGANEGILSCLMGLLNAGDEVIVF-EPFFDQYIPNIELCGGKVVYVPINPP 171 +K E V V+ GA+EGI + G + I++ P + Y + E G + VP Sbjct: 73 VKPEQVLVSRGADEGIELLIRAFCEPGKDAILYCPPTYGMYSVSAETIGVECRTVPT--- 129 Query: 172 KELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHN 231 LD W +D + + K V + +P+NP G++ ++ TL + + Sbjct: 130 --LDN-------WQLDLQGISDKLDG-VKVVYVCSPNNPTGQLINPQDFRTLLEL-TRGK 178 Query: 232 VVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELL 291 ++++DE Y S P + L + K+FA G R G+ L+ N E++ Sbjct: 179 AIVVADEAYIEFCPQASLAGWLAEYPHLAILR----TLSKAFALAGLRCGFTLA-NEEVI 233 Query: 292 SYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQ 331 + K +P PL A+ AL MR+ Sbjct: 234 NLLMK------VIAPYPLSTPVADIAAQALSPQGIVAMRE 267 >1M4N-A nrPDB Length = 435 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 63/324 (19%), Positives = 131/324 (40%), Gaps = 22/324 (6%) Query: 58 NLGQGFFSYSPPQFAIKEAQKAL--DIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKA 115 +L + + + +P A K+ +++ ++ + Y G P+ +++ + I ++ Sbjct: 53 DLLESWLAKNPEAAAFKKNGESIFAELALFQDY---HGLPAFKKAMVDFMAEIRGNKVTF 109 Query: 116 E--NVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIEL-CGGKVVYVPINPPK 172 + ++ +T GA + + L + G+ V++ P++ + +++ G ++V + Sbjct: 110 DPNHLVLTAGATSANETFIFCLADPGEAVLIPTPYYPGFDRDLKWRTGVEIVPIHCTSSN 169 Query: 173 ELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNV 232 T EE +++ EK + K V++ P NP+G TR EL L + + Sbjct: 170 GFQITETALEE---AYQEAEKR-NLRVKGVLVTNPSNPLGTTMTRNELYLLLSFVEDKGI 225 Query: 233 VIISDEVYEHLYFTD-SFTRIATL--------SPEIGQLTLTVGSAGKSFAATGWRIGWV 283 +ISDE+Y F+ SF + + + E+ Q V S K G+R+G + Sbjct: 226 HLISDEIYSGTAFSSPSFISVMEVLKDRNCDENSEVWQRVHVVYSLSKDLGLPGFRVGAI 285 Query: 284 LSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSI 343 S N +++ AA + S A + L Y + + + K S Sbjct: 286 YS-NDDMVVAAATKMSSFGLVSSQTQHLLSAMLSDKKLTKNYIAENHKRLKQRQKKLVSG 344 Query: 344 FDELGLPYTAPEGTYFVLVDFSKV 367 + G+ F VD + Sbjct: 345 LQKSGISCLNGNAGLFCWVDMRHL 368 >6HNB-A nrPDB Length = 491 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 65/289 (22%), Positives = 112/289 (38%), Gaps = 43/289 (14%) Query: 87 QYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFE 146 QY T G P + + + ++ + +V V+ G E S L + GD ++V E Sbjct: 104 QYGSTFGLPEFLQFIKEHTDMVHKVPYENWDVIVSVGNTEAWDSTLRTFCSKGDTILVEE 163 Query: 147 PFFDQYIPNIELCGGKVVYVPINP----PKELDQRNTRGEEWTIDFEQFEKAITSKTKAV 202 F + + G V V ++ P++L++ +R W + +F Sbjct: 164 YTFSSALESANGQGVNTVPVTMDEFGIIPEKLEELMSR---WVGNKPKF---------LY 211 Query: 203 IINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHL----YFTDSFTR------- 251 I T NP G + E + +I K++ +II DE Y L Y D R Sbjct: 212 TICTGQNPTGSSLSAERRKQIYDIACKYDFLIIEDEPYYFLQMETYTKDKAAREGKAVHD 271 Query: 252 ----IATLSPEIGQL-----TLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRIC 302 + L P L + + S K A G R+GW++ +LL + H + Sbjct: 272 HDEFLKALVPSFISLDVEGRVVRLDSFSKVLAP-GLRLGWIVG-QKDLLERYVRLH-EVS 328 Query: 303 FASPSPLQEACANSI----NDALKIGYFEKMRQEYINKFKIFTSIFDEL 347 +PS EA AN++ + + + +R EY +K + D+ Sbjct: 329 VQNPSGFSEALANALLRKWGHSGYLDWLIGLRAEYTHKRDVAIDALDQF 377 >6HNV-A nrPDB Length = 524 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 96/410 (23%), Positives = 171/410 (41%), Gaps = 70/410 (17%) Query: 78 KALDIPMVNQYSPTRGRPSLI----NSLIKLYSPIYNTELKAENVTVTTGANEGILSCLM 133 K +D+ QY+ G L+ + +I+ + P Y+ NV +TTGA++G+ Sbjct: 120 KLIDLARGLQYAAVEGHAPLLQFARDFIIRTHKPNYDDW----NVFITTGASDGLNKAAD 175 Query: 134 GLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEK 193 L+ GD ++V E F ++ + G K V V IN + D + ++ E +EK Sbjct: 176 VFLDDGDVILVEEFTFSPFLRFSDNAGAKAVPVKINFDNDSDGIDLT--QFVDLLENWEK 233 Query: 194 AITS--KTKAV-IINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYF----- 245 + K KA+ I T NP G + E + ++ VK++ II D+ Y +L Sbjct: 234 HYPNLPKPKALYTIATGQNPTGFTQSLEFRKKIYDLAVKYDFAIIEDDPYGYLTLPKYEK 293 Query: 246 ------------------TDSFTRIATLSPEIGQL-----TLTVGSAGKSFAATGWRIGW 282 D + + L+P +L L V + K FA G R+G+ Sbjct: 294 PNIGGSGSGNNELKNDLEIDDYLK-NHLTPSYLELDTTGRVLRVETFSKLFAP-GLRLGF 351 Query: 283 VLSLNAELLSYAAKAHTRICFASPSPLQEACANSI---NDALKIGYFE---KMRQEY-IN 335 ++ + E++ A K ++ + S L + N++ N G+ E KMR Y Sbjct: 352 IVG-HKEVID-AVKNYSDVVNRGASGLTQTIVNNVIQENFKGVDGWLEWILKMRLNYSYR 409 Query: 336 KFKIFTSIFDELG-----LPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISH 390 K + SIF+ + P+ FV K+ +P+D ++L K ++ Sbjct: 410 KDLLLYSIFESQAYKKGYVDVIDPKAGMFVTF---KINLPKDV----DVLQK---MKLLL 459 Query: 391 WLINELGVVAIPPTEFYIK-EHEKAAENLLR--FAVCKDDAYLENAVERL 437 W + G++ +P + E K N R +A+ +D + + +RL Sbjct: 460 WKLISYGILVVPGYNMTVDLEFSKDRSNFFRLCYALANNDEEILESGKRL 509 >3IF2-A nrPDB Length = 444 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 45/191 (23%), Positives = 80/191 (41%), Gaps = 34/191 (17%) Query: 75 EAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMG 134 +A + I M N YS +G + I++L+ ++ Y+ L +EN+ +T G+ + Sbjct: 67 KANSSAIISMAN-YSNPQGDSAFIDALVGFFNRHYDWNLTSENIALTNGSQ----NAFFY 121 Query: 135 LLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPP------------------KELDQ 176 L N V E D+ +++ K + +P+ P +D+ Sbjct: 122 LFNLFGGAFVNEHSQDKESKSVD----KSILLPLTPEYIGYSDVHVEGQHFAAVLPHIDE 177 Query: 177 RNTRGEE----WTIDFEQFEKAIT---SKTKAVIINTPHNPIGKVFTREELTTLGNICVK 229 GEE + +DFE E + A+ + P NP G V T EE+ L I + Sbjct: 178 VTHDGEEGFFKYRVDFEALENLPALKEGRIGAICCSRPTNPTGNVLTDEEMAHLAEIAKR 237 Query: 230 HNVVIISDEVY 240 +++ +I D Y Sbjct: 238 YDIPLIIDNAY 248 >3FDB-A nrPDB Length = 377 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 23/102 (22%), Positives = 51/102 (50%) Query: 186 IDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYF 245 I+ EK + +++++ P+NP+G VF E L L ++ +++ ++ DE++ L F Sbjct: 138 INLHDVEKGFQAGARSILLCNPYNPLGMVFAPEWLNELCDLAHRYDARVLVDEIHAPLVF 197 Query: 246 TDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLN 287 T A +S + +T+ + K++ G + ++ N Sbjct: 198 DGQHTVAAGVSDTAASVCITITAPSKAWNIAGLKCAQIIFSN 239 >2ZYJ-A nrPDB Length = 397 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 67/296 (22%), Positives = 121/296 (40%), Gaps = 47/296 (15%) Query: 87 QYSPTRGRPSLINSLIKLYSPIYN-----TELKAENVTVTTGANEGILSCLMGLLNAGDE 141 QYSPT G Y+P+ ++ E V +TTG+ + + L+ G Sbjct: 69 QYSPTEG-----------YAPLRAFVAEWIGVRPEEVLITTGSQQALDLVGKVFLDEGSP 117 Query: 142 VIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKA 201 V++ P + I L G + + VP GEE D + E+ + + Sbjct: 118 VLLEAPSYMGAIQAFRLQGPRFLTVPA------------GEEGP-DLDALEEVLKRERPR 164 Query: 202 VIINTP--HNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDS-FTRIATLSPE 258 + P NP G + L + ++ +V++ D+ Y LYF ++ + L+ E Sbjct: 165 FLYLIPSFQNPTGGLTPLPARKRLLQMVMERGLVVVEDDAYRELYFGEARLPSLFELARE 224 Query: 259 IG-QLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSI 317 G + +GS K + G R+ + ++ + E L +A +P L + + Sbjct: 225 AGYPGVIYLGSFSKVL-SPGLRVAFAVA-HPEALQKLVQAKQGADLHTPM-LNQML---V 278 Query: 318 NDALKIGY---FEKMRQEYINKFKIFTSIFDELGLP----YTAPEGTYFVLVDFSK 366 ++ LK G+ E++R+ Y K + D +P YT P+G FV ++ K Sbjct: 279 HELLKEGFSERLERVRRVYREKAQAMLHALDR-EVPKEVRYTRPKGGMFVWMELPK 333 >3EI8-A nrPDB Length = 432 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 45/174 (25%), Positives = 67/174 (38%), Gaps = 7/174 (4%) Query: 197 SKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLS 256 +T + +P+NP G TRE+LT L K+ +I+ D Y +Y +D R Sbjct: 197 GRTDIIFFCSPNNPTGAAATREQLTQLVEFAKKNGSIIVYDSAYA-MYMSDDNPRSIFEI 255 Query: 257 PEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYA---AKAHTRI---CFASPSPLQ 310 P ++ + S TG R+GW + L S AK RI CF S + Sbjct: 256 PGAEEVAMETASFSNYAGFTGVRLGWTVIPKKLLYSDGFPVAKDFNRIICTCFNGASNIS 315 Query: 311 EACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDF 364 +A A + + K+ Y I F LG + +V V F Sbjct: 316 QAGALACLTPEGLEAMHKVIGFYKENTNIIIDTFTSLGYDVYGGKNAPYVWVHF 369 >3ASB-A nrPDB Length = 400 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 41/198 (20%), Positives = 78/198 (39%), Gaps = 20/198 (10%) Query: 88 YSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEP 147 Y P G P+L KL Y + A+ + ++ GA + L+ V + +P Sbjct: 71 YGPDFGLPALRQ---KLSEDFYRGFVDAKEIFISDGAKVDLFR-LLSFFGPNQTVAIQDP 126 Query: 148 FFDQYIPNIELCGGK-VVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINT 206 + Y+ L G K ++ +P Q N E+ D + + + + Sbjct: 127 SYPAYLDIARLTGAKEIIALPCL------QENAFFPEFPED---------THIDILCLCS 171 Query: 207 PHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTV 266 P+NP G V +++L + + ++H ++I+ D Y S + P+ + + Sbjct: 172 PNNPTGTVLNKDQLRAIVHYAIEHEILILFDAAYSTFISDPSLPKSIFEIPDARFCAIEI 231 Query: 267 GSAGKSFAATGWRIGWVL 284 S K G R+GW + Sbjct: 232 NSFSKPLGFAGIRLGWTV 249 >1X0M-A nrPDB Length = 403 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 72/302 (23%), Positives = 124/302 (41%), Gaps = 39/302 (12%) Query: 74 KEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLM 133 K A KAL QY T+G L +L+K Y + ++ +T+G+ + + Sbjct: 61 KYADKAL------QYGTTKGFTPLRETLMKWLGKRYGIS-QDNDIMITSGSQQALDLIGR 113 Query: 134 GLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEK 193 LN GD V+V P + + + + +P LD + E E+ K Sbjct: 114 VFLNPGDIVVVEAPTYLAALQAFNFYEPQYIQIP------LDDEGMKVE----ILEEKLK 163 Query: 194 AITSKTKAV----IINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHL-YFTDS 248 + S+ K V + T NP G + L + +++ +++ D+ Y L Y + Sbjct: 164 ELKSQGKKVKVVYTVPTFQNPAGVTMNEDRRKYLLELASEYDFIVVEDDPYGELRYSGNP 223 Query: 249 FTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYA-AKAHTRICFASPS 307 +I L E G++ + +G+ K A G+RIGW++ + AK T +C + Sbjct: 224 EKKIKALDNE-GRV-IYLGTFSKILAP-GFRIGWMVGDPGIIRKMEIAKQSTDLC---TN 277 Query: 308 PLQEACANSINDALKIGYFEK----MRQEYINKFKIFTSIFDEL---GLPYTAPEGTYFV 360 + A D GY EK +R+ Y + +E G+ +T PEG F+ Sbjct: 278 VFGQVVAWRYVDG---GYLEKHIPEIRKFYKPRRDAMLEALEEFMPEGVKWTKPEGGMFI 334 Query: 361 LV 362 V Sbjct: 335 WV 336 >4FL0-A nrPDB Length = 456 Score = 48.1 bits (113), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 47/185 (25%), Positives = 74/185 (40%), Gaps = 29/185 (15%) Query: 112 ELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGG---------- 161 +K+ V V+ GA I S L LL + + V +P F YI + + G Sbjct: 130 HVKSNEVFVSDGAQSDI-SRLQLLLGSNVTIAVQDPTFPAYIDSSVIIGQTGHFHEKTKK 188 Query: 162 --KVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREE 219 VVY+P P + A+T +T + +P+NP G V +R++ Sbjct: 189 YQNVVYMPCGPNNSFFP---------------DLAMTPRTDVIFFCSPNNPTGYVASRKQ 233 Query: 220 LTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWR 279 L L + + +II D Y + D R P ++ + V S K TG R Sbjct: 234 LHQLVDFAKTNGSIIIFDSAYA-AFIEDGSPRSIYEIPGAREVAIEVSSFSKFAGFTGVR 292 Query: 280 IGWVL 284 +GW + Sbjct: 293 LGWSI 297 >3AV7-A nrPDB Length = 448 Score = 48.1 bits (113), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 72/302 (23%), Positives = 124/302 (41%), Gaps = 39/302 (12%) Query: 74 KEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLM 133 K A KAL QY T+G L +L+K Y + ++ +T+G+ + + Sbjct: 106 KYADKAL------QYGTTKGFTPLRETLMKWLGKRYGIS-QDNDIMITSGSQQALDLIGR 158 Query: 134 GLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEK 193 LN GD V+V P + + + + +P LD + E E+ K Sbjct: 159 VFLNPGDIVVVEAPTYLAALQAFNFYEPQYIQIP------LDDEGMKVE----ILEEKLK 208 Query: 194 AITSKTKAV----IINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHL-YFTDS 248 + S+ K V + T NP G + L + +++ +++ D+ Y L Y + Sbjct: 209 ELKSQGKKVKVVYTVPTFQNPAGVTMNEDRRKYLLELASEYDFIVVEDDPYGELRYSGNP 268 Query: 249 FTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYA-AKAHTRICFASPS 307 +I L E G++ + +G+ K A G+RIGW++ + AK T +C + Sbjct: 269 EKKIKALDNE-GRV-IYLGTFSK-ILAPGFRIGWMVGDPGIIRKMEIAKQSTDLC---TN 322 Query: 308 PLQEACANSINDALKIGYFEK----MRQEYINKFKIFTSIFDEL---GLPYTAPEGTYFV 360 + A D GY EK +R+ Y + +E G+ +T PEG F+ Sbjct: 323 VFGQVVAWRYVDG---GYLEKHIPEIRKFYKPRRDAMLEALEEFMPEGVKWTKPEGGMFI 379 Query: 361 LV 362 V Sbjct: 380 WV 381 >1WST-A nrPDB Length = 417 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 75/352 (21%), Positives = 131/352 (37%), Gaps = 52/352 (14%) Query: 74 KEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLM 133 + A KAL QY T+G L +L + Y+ + + G+ + + Sbjct: 71 EHADKAL------QYGTTKGFTPLRLALARWMEKRYDIPMSKVEIMTVAGSQQALDLIGR 124 Query: 134 GLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEK 193 LN GD ++V P + I + + + +P LD + R + E+ K Sbjct: 125 VFLNPGDPIVVEAPTYLAAIQAFKYYDPEFISIP------LDDKGMRVDLLEEKLEELRK 178 Query: 194 AITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIA 253 ++T NP G + + L + +++ +I+ D Y L ++ T Sbjct: 179 QGKRVKIVYTVSTFQNPAGVTMSVDRRKKLLELANEYDFLIVEDGPYSELRYSGEPTPPI 238 Query: 254 TLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEAC 313 + G++ + +G+ K A G+RIGWV AA H + C Sbjct: 239 KHFDDYGRV-IYLGTFSKILAP-GFRIGWV----------AAHPHLIRKMEIAKQSIDLC 286 Query: 314 ANSINDALKIGYFEK-MRQEYINKFKIF-----TSIFDEL------GLPYTAPEGTYFVL 361 N+ A+ Y E E+I K F ++ + L G+ +T PEG FV Sbjct: 287 TNTFGQAIAWKYVENGYLDEHIPKIIEFYKPRRDAMLEALEEYMPEGVEWTKPEGGMFV- 345 Query: 362 VDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEK 413 +V +PE G D ++ GV +P F++ +K Sbjct: 346 ----RVTLPE-----------GIDTKLMMERAVAKGVAYVPGEAFFVHRDKK 382 >4JE5-A nrPDB Length = 503 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 71/295 (24%), Positives = 118/295 (40%), Gaps = 38/295 (12%) Query: 71 FAIKEAQKALDIPMVN--QYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGI 128 +A K A + DIP+ QY + G+P L+N + I++ + K +V T G Sbjct: 89 YADKSANPSNDIPLSRALQYGFSAGQPELLNFIRDHTKIIHDLKYKDWDVLATAGNTNAW 148 Query: 129 LSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTR-GEEWTID 187 S L N GD ++V F + + E G VPI+ + ++ + E WT Sbjct: 149 ESTLRVFCNRGDVILVEAHSFSSSLASAEAQGVITFPVPIDADGIIPEKLAKVMENWTPG 208 Query: 188 FEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHL---- 243 + + T I T NP G + I K++ +I+ DE Y L Sbjct: 209 APKPKLLYT-------IPTGQNPTGTSIADHRKEAIYKIAQKYDFLIVEDEPYYFLQMNP 261 Query: 244 YFTDSFTR-IATLSPE---------IGQLTLTVGSAGK-----SFA---ATGWRIGWVLS 285 Y D R A SP+ + L++ + G+ SF+ A G R+GW+ Sbjct: 262 YIKDLKEREKAQSSPKQDHDEFLKSLANTFLSLDTEGRVIRMDSFSKVLAPGTRLGWITG 321 Query: 286 LNAELLSYAAKAHTRICFASPSPLQEACAN-SINDALKIGYFE---KMRQEYINK 336 + L Y + I +P+ + N +++ + GY + +R EY K Sbjct: 322 SSKILKPYLSLHEMTI--QAPAGFTQVLVNATLSRWGQKGYLDWLLGLRHEYTLK 374 >3LY1-A nrPDB Length = 354 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 58/267 (21%), Positives = 117/267 (43%), Gaps = 30/267 (11%) Query: 112 ELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPP 171 +++A ++ +T G++EGI + + + ++++ E + ++ G KV V Sbjct: 65 QVEAPSILLTAGSSEGIRAAIEAYASLEAQLVIPELTYGDGEHFAKIAGMKVTKV----- 119 Query: 172 KELDQRNTRGEEWTIDFEQFEKAIT--SKTKAVIINTPHNPIGKVFTREELTTLGNICVK 229 K LD W D E + A+ S V + P+NP G + T ++ Sbjct: 120 KMLDN-------WAFDIEGLKAAVAAYSGPSIVYLVNPNNPTGTI-TPADVIEPWIASKP 171 Query: 230 HNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAE 289 N + I DE Y F I+ + + + + + + K A G R+G+ ++ + Sbjct: 172 ANTMFIVDEAYAEFVNDPRFRSISPMITQGAENIILLKTFSKIHAMAGMRVGYAVA-HPT 230 Query: 290 LLSYAAK--AHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDEL 347 +++ + A +I F+ +A S+ND+ I Y +K +++ +I ++L Sbjct: 231 VIALMGRYVAGEKINFSG----VDAALASMNDSAFITYSKKSND--VSR-QILLKALEDL 283 Query: 348 GLPYTAPEGTYFVLVDFSKVKIP-EDY 373 LPY EG + F ++ +P +DY Sbjct: 284 KLPYLPSEGNFV----FHQLVVPLKDY 306 >1VP4-A nrPDB Length = 425 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 74/304 (24%), Positives = 119/304 (39%), Gaps = 61/304 (20%) Query: 87 QYSPTRGRPSLINSLIKLYSPIYN-TELKAENVTVTTGANEGILSCLMGLLNAGDE--VI 143 QYS T G P L ++KL +Y T L +N+ T G+ + + L+G L DE + Sbjct: 80 QYSTTEGDPVLKQQILKLLERMYGITGLDEDNLIFTVGSQQAL--DLIGKLFLDDESYCV 137 Query: 144 VFEP-------FFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAIT 196 + +P F QY+ N V VP+ E+ +D E+ ++ Sbjct: 138 LDDPAYLGAINAFRQYLANF-------VVVPL-------------EDDGMDLNVLERKLS 177 Query: 197 -----SKTKAV----IINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYF-- 245 K K V +++ HNP G + E+ L I K+++ I+ D+ Y L + Sbjct: 178 EFDKNGKIKQVKFIYVVSNFHNPAGVTTSLEKRKALVEIAEKYDLFIVEDDPYGALRYEG 237 Query: 246 --TDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICF 303 D +I PE L T A G RIG V + E + +A Sbjct: 238 ETVDPIFKIG--GPERVVLLNTFSKV----LAPGLRIGMVAG-SKEFIRKIVQAKQSADL 290 Query: 304 ASPSPLQEACANSIN--DALK-----IGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEG 356 SP+ A + D L+ I + + R +N + + S D G+ + EG Sbjct: 291 CSPAITHRLAARYLERYDLLEQLKPTIELYRRKRTVMLNALEEYFS--DIPGVKWVKSEG 348 Query: 357 TYFV 360 F+ Sbjct: 349 GLFI 352 >3CQ5-A nrPDB Length = 369 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 73/361 (20%), Positives = 146/361 (40%), Gaps = 62/361 (17%) Query: 85 VNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIV 144 +N+Y P R L + L + + +N+ G+NE + L G + Sbjct: 63 LNRY-PERDAVELRDELAAYITKQTGVAVTRDNLWAANGSNEILQQLLQAFGGPGRTALG 121 Query: 145 FEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVI- 203 F+P + + I G ++ + +RG ++ ID + + I +K ++ Sbjct: 122 FQPSYSMH--PILAKGTHTEFIAV----------SRGADFRIDMDVALEEIRAKQPDIVF 169 Query: 204 INTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLT 263 + TP+NP G V + +++ + N+ ++I DE Y + S T + P ++ Sbjct: 170 VTTPNNPTGDVTSLDDVERIINVAPG---IVIVDEAYAEFSPSPSATTLLEKYPTKLVVS 226 Query: 264 LTVGSAGKSFAATGWRIGWVLS----LNAELLSYAAKAHTRICFASPSPLQEACANSI-N 318 T+ K+F G R+G+ ++ ++A +L R+ + + Q A ++ + Sbjct: 227 RTM---SKAFDFAGGRLGYFVANPAFIDAVML-------VRLPYHLSALSQAAAIVALRH 276 Query: 319 DALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEE 378 A +G EK+ E + + +ELG E + DFS + + + Sbjct: 277 SADTLGTVEKLSVERVR----VAARLEELGYAVVPSESNFVFFGDFS-----DQHAAWQA 327 Query: 379 ILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLK 438 L++G LI ++G+ T + E ++DA+L+ A E +K Sbjct: 328 FLDRG-------VLIRDVGIAGHLRTTIGVPE--------------ENDAFLDAAAEIIK 366 Query: 439 L 439 L Sbjct: 367 L 367 >3IHJ-A nrPDB Length = 498 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 72/327 (22%), Positives = 141/327 (43%), Gaps = 49/327 (14%) Query: 116 ENVTVTTGANEGILSCLMGLLNAGDE----VIVFEPFFDQYIPNI-ELCGGKVVYVPINP 170 +N+ +TTGA++GI + L L++ G + V++ P + Y I EL +V Y Sbjct: 154 DNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYY---- 209 Query: 171 PKELDQRNTRGEEWTIDFEQFEKAIT-----SKTKAVIINTPHNPIGKVFTREELTTLGN 225 LD+ N W ++ + +A+ K + I P NP G+V +R+ + + + Sbjct: 210 ---LDEENC----WALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIH 262 Query: 226 ICVKHNVVIISDEVYE-HLYFTD----SFTRIA-TLSPEIG---QLTLTVGSAGKSFAAT 276 + + +++DEVY+ ++Y D SF ++ + PE +L ++ Sbjct: 263 FAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGEC 322 Query: 277 GWRIGW--VLSLNAELLSYAAK-AHTRICFASPSPLQEACANSINDALKIG--YFEKMRQ 331 G+R G+ V++L+ E+ K R+C P +A + + + G FE+ + Sbjct: 323 GYRGGYMEVINLHPEIKGQLVKLLSVRLC---PPVSGQAAMDIVVNPPVAGEESFEQFSR 379 Query: 332 E-------YINKFKIFTSIFDEL-GLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKG 383 E K K+ +F+++ G+ +G + F ++ IP + Sbjct: 380 EKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYA---FPRIFIPAKAVEAAQAHQMA 436 Query: 384 KDFRISHWLINELGVVAIPPTEFYIKE 410 D L+ E G+ +P + F +E Sbjct: 437 PDMFYCMKLLEETGICVVPGSGFGQRE 463 >1AY8-A nrPDB Length = 394 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 64/258 (24%), Positives = 106/258 (41%), Gaps = 40/258 (15%) Query: 51 NQGRELINLGQGFF----SYSPPQFAIKEA-QKALDIPMVNQYSPTRGRPSLINSLIKLY 105 QG+ I+LG G + ++P A+ A Q+ L+ Y+ G P ++ +L Sbjct: 25 RQGK--IDLGVGVYKDATGHTPIMRAVHAAEQRMLETETTKTYAGLSGEPEFQKAMGEL- 81 Query: 106 SPIYNTELKAEN-VTVTTGANEGILSC---LMGLLNAGDEVIVFEPFFDQYIPNIELCGG 161 I LK+E T+ T G L L + N V V +P + ++ + G Sbjct: 82 --ILGDGLKSETTATLATVGGTGALRQALELARMANPDLRVFVSDPTWPNHVSIMNFMG- 138 Query: 162 KVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVII---NTPHNPIGKVFTRE 218 +P+ + D TRG +DFE + + + K ++ HNP G T + Sbjct: 139 ----LPVQTYRYFDA-ETRG----VDFEGMKADLAAAKKGDMVLLHGCCHNPTGANLTLD 189 Query: 219 ELTTLGNICVKHNVVIISDEVYEHLYFTDSF------TR-IATLSPEIGQLTLTVGSAGK 271 + + +I K + + D Y+ F D TR IA+ PE+ L S K Sbjct: 190 QWAEIASILEKTGALPLIDLAYQG--FGDGLEEDAAGTRLIASRIPEV----LIAASCSK 243 Query: 272 SFAATGWRIGWVLSLNAE 289 +F R G +L+L A+ Sbjct: 244 NFGIYRERTGCLLALCAD 261 >3QGU-A nrPDB Length = 449 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 40/183 (21%), Positives = 68/183 (37%), Gaps = 8/183 (4%) Query: 188 FEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTD 247 F KA +T + +P+NP G TR +LT L N K+ +++ D Y Sbjct: 201 FPDLSKA--KRTDIIFFCSPNNPTGAAATRAQLTELVNFARKNGSILVYDAAYALYISNP 258 Query: 248 SFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHT---RI--- 301 + P ++ + S K TG R+GW + A + H R+ Sbjct: 259 DCPKTIYEIPGADEVAIETCSFSKYAGFTGVRLGWTVVPKALKYANGEPVHADWNRVMTT 318 Query: 302 CFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVL 361 CF S + +A + + M + Y +I + F E+G + ++ Sbjct: 319 CFNGASNIVQAGGLACLQPEGLKEMNAMIKFYKENAQILKTTFTEMGFSVYGGDDAPYIW 378 Query: 362 VDF 364 V F Sbjct: 379 VGF 381 >3G7Q-A nrPDB Length = 417 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 32/132 (24%), Positives = 57/132 (43%), Gaps = 7/132 (5%) Query: 112 ELKAENVTVTTGANEG---ILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPI 168 +++ +N+ +T G+ + + G G V P +YI + ++V Sbjct: 95 DIEPQNIALTNGSQSAFFYLFNLFAGRRADGSTKKVLFPLAPEYIGYADSGLEDDLFVSA 154 Query: 169 NPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICV 228 P EL ++ +DFE I +T + ++ P NP G V T EEL L + Sbjct: 155 RPNIELLPEGQF--KYHVDFEHLH--IGEETGMICVSRPTNPTGNVITDEELMKLDRLAN 210 Query: 229 KHNVVIISDEVY 240 +HN+ ++ D Y Sbjct: 211 QHNIPLVIDNAY 222 >1UU1-A nrPDB Length = 335 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 42/176 (23%), Positives = 71/176 (40%), Gaps = 36/176 (20%) Query: 113 LKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPK 172 L NV+V GA+E I+ +M + D + F P + Y + G K + VP+ Sbjct: 74 LSKNNVSVGNGADE-IIYVMMLMF---DRSVFFPPTYSCYRIFAKAVGAKFLEVPLTKDL 129 Query: 173 ELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNV 232 + + N GE V I P+NP G VF REE+ + +K Sbjct: 130 RIPEVNV-GE----------------GDVVFIPNPNNPTGHVFEREEIERI----LKTGA 168 Query: 233 VIISDEVYEHLY---FTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLS 285 + DE Y + + D + L+ + + K+F+ R+G+V++ Sbjct: 169 FVALDEAYYEFHGESYVDFLKKYENLA--------VIRTFSKAFSLAAQRVGYVVA 216 >3FFH-A nrPDB Length = 363 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 60/254 (23%), Positives = 100/254 (39%), Gaps = 21/254 (8%) Query: 112 ELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPP 171 +L+ E + T G +E I LL+ ++ P F QY N + G +V +P+ Sbjct: 81 QLEEEELIFTAGVDELIELLTRVLLDTTTNTVMATPTFVQYRQNALIEGAEVREIPLLQD 140 Query: 172 KELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHN 231 E D E AI KT V I P+NP G ++ + V + Sbjct: 141 GEH------------DLEGMLNAIDEKTTIVWICNPNNPTGNYIELADIQAFLD-RVPSD 187 Query: 232 VVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELL 291 V+++ DE Y Y T + L L +T + K + R+G+ ++ + E++ Sbjct: 188 VLVVLDEAYIE-YVTPQPEKHEKLVRTYKNLIIT-RTFSKIYGLASARVGYGIA-DKEII 244 Query: 292 SYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPY 351 R F + S Q+ +I D IG I +++ F F+++ L Sbjct: 245 RQL--NIVRPPFNTTSIGQKLAIEAIKDQAFIGECRTSNANGIKQYEAFAKRFEKVKL-- 300 Query: 352 TAPEGTYFVLVDFS 365 P FVL+D Sbjct: 301 -YPANGNFVLIDLG 313 >4R2N-A nrPDB Length = 367 Score = 41.6 bits (96), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 43/201 (21%), Positives = 75/201 (37%), Gaps = 20/201 (9%) Query: 85 VNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIV 144 VN+Y P G L +L + P + E+V V G+ + + GDEV+ Sbjct: 52 VNRY-PDNGCVQLKAALARHLGP----DFAPEHVAVGCGSVSLCQQLVQVTASVGDEVVF 106 Query: 145 FEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVII 204 F+ Y P + + G + VP+ + T D +T +T+ + + Sbjct: 107 GWRSFELYPPQVRVAGAIPIQVPLT-------------DHTFDLYAMLATVTDRTRLIFV 153 Query: 205 NTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTL 264 P+NP V + L H ++I DE Y Y D + + Sbjct: 154 CNPNNPTSTVVGPDALARFVEAVPAH-ILIAIDEAYVE-YIRDGMRPDSLGLVRAHNNVV 211 Query: 265 TVGSAGKSFAATGWRIGWVLS 285 + + K++ G RIG+ + Sbjct: 212 VLRTFSKAYGLAGLRIGYAIG 232 >5DJ3-A nrPDB Length = 376 Score = 41.6 bits (96), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 48/201 (23%), Positives = 73/201 (36%), Gaps = 38/201 (18%) Query: 93 GRPSLINSLIKLYS-----PIYNTELKAENVTVTTGANEG-------ILSC--------- 131 G+ ++N L L++ P+ E +A T G +LSC Sbjct: 37 GQQKIVNELPVLWAESEQRPVQQIESEAHQAYFTLLGQHGYPAEPGRVLSCYSSSVSMEI 96 Query: 132 LMGLLNAG-DEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQ 190 L L+A D V + P FD I ++ L G + VP+ EE + Sbjct: 97 LARSLSASVDRVALVHPTFDN-IADL-LRGNGLDLVPV-------------EEDALHGAD 141 Query: 191 FEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFT 250 + S V + TP+NP G+V E L L C +H V+ D + + Sbjct: 142 LSAELLSSVGCVFVTTPNNPTGRVLAEERLRRLAEQCAEHGTVLALDTSFRGFDAAAHYD 201 Query: 251 RIATLSPEIGQLTLTVGSAGK 271 A L E G + + GK Sbjct: 202 HYAVLQ-EAGCRWVVIEDTGK 221 >5WT2-A nrPDB Length = 401 Score = 41.2 bits (95), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 46/158 (29%), Positives = 68/158 (43%), Gaps = 26/158 (16%) Query: 91 TRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGL-----LNAGDEVIVF 145 T P++ +L KLY I ++ ++V +T+ A E L G+ L G IV Sbjct: 42 TETHPAIAEALDKLYKGINARDI--DDVIITSCATESNNWVLKGVYFDECLKKGKNHIVT 99 Query: 146 ----EPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKA 201 P +E G +V Y+PIN E +I EQ +AIT KT Sbjct: 100 TVAEHPAVRSTCNFLESLGVEVTYLPIN------------EHGSITAEQVREAITEKTAL 147 Query: 202 VIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEV 239 V + +N G +F EE +G IC + V+ +D V Sbjct: 148 VSVMWANNETGLIFPIEE---IGAICKEKGVLFHTDAV 182 >3UWC-A nrPDB Length = 374 Score = 41.2 bits (95), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 37/120 (30%), Positives = 51/120 (42%), Gaps = 18/120 (15%) Query: 118 VTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQR 177 + V TG + +S M + AGDEVI F + I G V V D Sbjct: 57 IGVGTGTDALAMSFKMLNIGAGDEVITCANTFIASVGAIVQAGATPVLV--------DSE 108 Query: 178 NTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISD 237 N + ID E+ E AIT KTKA++ P+ ++ L I KHN+ I+ D Sbjct: 109 NG----YVIDPEKIEAAITDKTKAIM------PVHYTGNIADMPALAKIAKKHNLHIVED 158 >4K2M-A nrPDB Length = 443 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 40/155 (25%), Positives = 68/155 (43%), Gaps = 21/155 (13%) Query: 105 YSPIYNTELKAENVTVTTGANEGILSCLMGL-LNAGDEVIVFEPFFDQYIPNIELCGGKV 163 + + +T L V T+ + I+ L+ L LN GDEVI+ F + GG Sbjct: 108 FEKVLSTYLHKRYVIATSSGTDAIMIGLLALGLNPGDEVIMPANSFSATENAVLASGGVP 167 Query: 164 VYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTL 223 +YV INP + + ID ++ E+AIT TK ++ P+ ++ + Sbjct: 168 IYVDINP-----------QTFCIDPDKIEEAITPYTKFIL------PVHLYGKHSDMQHI 210 Query: 224 GNICVKHNVVIISDEVYEHLYFTD--SFTRIATLS 256 I ++ + +I D + + TD + I TLS Sbjct: 211 RQIANRYKLKVIEDAC-QGIGLTDLGKYADITTLS 244 >2X5F-A nrPDB Length = 430 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 38/130 (29%), Positives = 57/130 (43%), Gaps = 21/130 (16%) Query: 202 VIINTPHNPIGKVFTREELTT-------LGNICVKHNVVIISDEVYEHLYFTDS-----F 249 +I+N P+NP G T +E+TT L N K V+ + D+ Y L++ D F Sbjct: 193 MILNYPNNPTGYTPTHKEVTTIVEAIKALANKGTK--VIAVVDDAYYGLFYEDVYTQSLF 250 Query: 250 TRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVL-----SLNAELLSYAAKAHTRICFA 304 T + L L + + A K F A G+R+G++ E+L K R + Sbjct: 251 TALTNLHSN-AILPIRLDGATKEFFAWGFRVGFMTFGTSDQTTKEVLEAKVKGLIRSNIS 309 Query: 305 S-PSPLQEAC 313 S P P Q A Sbjct: 310 SGPLPTQSAV 319 >6CJB-A nrPDB Length = 391 Score = 38.1 bits (87), Expect = 0.009, Method: Compositional matrix adjust. Identities = 30/118 (25%), Positives = 52/118 (44%), Gaps = 27/118 (22%) Query: 129 LSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDF 188 ++ ++ LL +GD V+ + +L GG + D+ TR + F Sbjct: 89 INTVIDLLGSGDHVVAMD----------DLYGGTF--------RLFDKVKTRTSNLSFSF 130 Query: 189 ------EQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVY 240 E E AIT KTK + + TP NP+ K+ L + I K+N++ ++D + Sbjct: 131 IDMSVPENIEAAITPKTKLLWLETPSNPMLKL---ANLRKIAAIAKKYNLITVADNTF 185 >3GET-A nrPDB Length = 365 Score = 37.4 bits (85), Expect = 0.013, Method: Compositional matrix adjust. Identities = 44/197 (22%), Positives = 85/197 (43%), Gaps = 17/197 (8%) Query: 99 NSLIKLYSPIYNT-ELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIE 157 +S+I+L S + +++ EN+ + G+++ I + LN+ + + F Y + Sbjct: 65 DSMIELKSTLAQKYKVQNENIIIGAGSDQVIEFAIHSKLNSKNAFLQAGVTFAMYEIYAK 124 Query: 158 LCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTR 217 CG K Y + LD+ F++ + + K + + P+NP+G+ Sbjct: 125 QCGAKC-YKTQSITHNLDE-----------FKKLYETHKDEIKLIFLCLPNNPLGECLDA 172 Query: 218 EELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRI--ATLSPEIGQLTLTVGSAGKSFAA 275 E T + +V+I E F DS + L E + L +G+ K + Sbjct: 173 SEATEFIKGVNEDCLVVIDAAYNEFASFKDSKKHLEPCELIKEFDNV-LYLGTFSKLYGL 231 Query: 276 TGWRIGWVLSLNAELLS 292 G RIG+ ++ NA ++S Sbjct: 232 GGLRIGYGIA-NANIIS 247 >5TSU-A nrPDB Length = 422 Score = 37.0 bits (84), Expect = 0.016, Method: Compositional matrix adjust. Identities = 38/125 (30%), Positives = 55/125 (44%), Gaps = 23/125 (18%) Query: 191 FEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFT 250 E AIT +TK V I TP NP KV ++ +I KH +I+ V ++ + + F Sbjct: 160 LEAAITPETKLVWIETPTNPTQKVI---DIEGCAHIVHKHGDIIL---VVDNTFMSPYFQ 213 Query: 251 RIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICF------A 304 R L +I + T G S G ++S+N E L H R+ F A Sbjct: 214 RPLALGADISMYSATKYMNGHSDVVMG-----LVSVNCESL------HNRLRFLQNSLGA 262 Query: 305 SPSPL 309 PSP+ Sbjct: 263 VPSPI 267 >4PIW-A nrPDB Length = 396 Score = 36.6 bits (83), Expect = 0.020, Method: Compositional matrix adjust. Identities = 28/109 (25%), Positives = 47/109 (43%), Gaps = 17/109 (15%) Query: 129 LSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDF 188 ++ L+ + GDEVI+ F L G K+V+V + P + ID Sbjct: 81 MAALLLDIQPGDEVIMPSYTFVSTANAFVLRGAKIVFVDVRP-----------DTMNIDE 129 Query: 189 EQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISD 237 E AIT KT+ ++ P+ E+ T+ + KHN+ ++ D Sbjct: 130 TLIEAAITDKTRVIV------PVHYAGVACEMDTIMALAKKHNLFVVED 172 >3FTB-A nrPDB Length = 361 Score = 36.2 bits (82), Expect = 0.026, Method: Compositional matrix adjust. Identities = 48/207 (23%), Positives = 89/207 (42%), Gaps = 32/207 (15%) Query: 112 ELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPP 171 +LK + + GA+E I+ + L +++++ P + +Y N + G VV+ ++ Sbjct: 75 KLKDIGIVLGNGASE-IIELSISLF---EKILIIVPSYAEYEINAKKHGVSVVFSYLD-- 128 Query: 172 KELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHN 231 E ID+E I +VII P+NP G + +E+ + + + Sbjct: 129 ----------ENMCIDYEDIISKIDD-VDSVIIGNPNNPNGGLINKEKFIHVLKLAEEKK 177 Query: 232 VVIISDEVYEHLYFTDSFTRIATLSPEIGQLT--LTVGSAGKSFAATGWRIGWVLSLNAE 289 II DE + + FT + ++ EI + + + K FA G R G+ ++ N E Sbjct: 178 KTIIIDEAF--IEFTGDPS--SSFVGEIKNYSCLFIIRAMTKFFAMPGIRFGYGITNNKE 233 Query: 290 LLSYAAKAHTRI------CFASPSPLQ 310 + AAK + CFA + + Sbjct: 234 I---AAKIKAKQNPWNINCFAEMAAIN 257 >4IYO-A nrPDB Length = 397 Score = 36.2 bits (82), Expect = 0.029, Method: Compositional matrix adjust. Identities = 31/115 (26%), Positives = 51/115 (44%), Gaps = 23/115 (20%) Query: 130 SCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTI--- 186 S +M LL+AG V+ + +L GG E +R T G +++ Sbjct: 93 STVMELLDAGSHVVAMD----------DLYGGTFRLF------ERVRRRTAGLDFSFVDL 136 Query: 187 -DFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVY 240 D F+ AI + TK V I TP NP+ K+ ++ + I KH ++ + D + Sbjct: 137 TDPAAFKAAIRADTKMVWIETPTNPMLKLV---DIAAIAVIARKHGLLTVVDNTF 188 >4L0O-H nrPDB Length = 388 Score = 36.2 bits (82), Expect = 0.031, Method: Compositional matrix adjust. Identities = 19/63 (30%), Positives = 32/63 (50%), Gaps = 3/63 (4%) Query: 185 TIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLY 244 T D Q +KAI TKA+ + TP NP+ K+ +L ++ H ++ I D + Y Sbjct: 121 TSDISQIKKAIKPNTKALYLETPSNPLLKI---TDLAQCASVAKDHGLLTIVDNTFATPY 177 Query: 245 FTD 247 + + Sbjct: 178 YQN 180 >6BLG-A nrPDB Length = 379 Score = 35.8 bits (81), Expect = 0.039, Method: Compositional matrix adjust. Identities = 30/109 (27%), Positives = 48/109 (44%), Gaps = 17/109 (15%) Query: 129 LSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDF 188 ++ L+ + GDEVI+ F L G K+V+V I R + ID Sbjct: 64 MAALLLDIQPGDEVIMPSYTFVSTANAFVLRGAKIVFVDI-----------RRDTMNIDE 112 Query: 189 EQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISD 237 E AIT KT+A++ P+ E+ T+ I K+N+ ++ D Sbjct: 113 TLIEAAITDKTRAIV------PVHYAGVACEMDTIMAIADKYNLFVVED 155 >5K8B-A nrPDB Length = 403 Score = 33.5 bits (75), Expect = 0.18, Method: Compositional matrix adjust. Identities = 29/103 (28%), Positives = 46/103 (44%), Gaps = 20/103 (19%) Query: 136 LNAGDEVIVFEPF-FDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKA 194 + AGDEVIV PF F + I + G ++ I+ E + E E Sbjct: 74 IGAGDEVIV-PPFTFVASVEAIFMAGAVPIFAEID------------ETLCLSPEGIEAV 120 Query: 195 ITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISD 237 IT +TKA+ N + + ++ + IC KHN+V++ D Sbjct: 121 ITPRTKAI------NLVHMCGSMAKMDEIKAICKKHNLVLLED 157 >1LC8-A nrPDB Length = 364 Score = 33.5 bits (75), Expect = 0.18, Method: Compositional matrix adjust. Identities = 37/175 (21%), Positives = 70/175 (40%), Gaps = 18/175 (10%) Query: 112 ELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPP 171 ++ A + G E I + GL ++ P F +Y + G ++ Sbjct: 73 QVPASWILAGNGETESIFTVASGL--KPRRAMIVTPGFAEYGRALAQSGCEI-------- 122 Query: 172 KELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHN 231 + R G + T + +A+T + + TP+NP G + R L + + C N Sbjct: 123 RRWSLREADGWQLT---DAILEALTPDLDCLFLCTPNNPTGLLPERPLLQAIADRCKSLN 179 Query: 232 VVIISDEVY-EHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLS 285 + +I DE + + + F +P I L S K +A G R+G++++ Sbjct: 180 INLILDEAFIDFIPHETGFIPALKDNPHIWVLR----SLTKFYAIPGLRLGYLVN 230 >3NYS-A nrPDB Length = 367 Score = 33.5 bits (75), Expect = 0.19, Method: Compositional matrix adjust. Identities = 31/102 (30%), Positives = 44/102 (43%), Gaps = 23/102 (22%) Query: 139 GDEVIVFEPFFDQYIPNIE---LCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAI 195 GDEVI P F Y+ E L G K VYV I+P + +D + E AI Sbjct: 75 GDEVIT--PGF-TYVATAETVALLGAKPVYVDIDP-----------RTYNLDPQLLEAAI 120 Query: 196 TSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISD 237 T +TKA+I P+ + + I K+ + +I D Sbjct: 121 TPRTKAII------PVSLYGQCADFDAINAIASKYGIPVIED 156 >3EUC-A nrPDB Length = 367 Score = 33.5 bits (75), Expect = 0.19, Method: Compositional matrix adjust. Identities = 37/174 (21%), Positives = 71/174 (40%), Gaps = 31/174 (17%) Query: 118 VTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQR 177 V + G++E I + G +V+ P F Y + + G + V VP+ Sbjct: 88 VLLGNGSDEIISMLALAAARPGAKVMAPVPGFVMYAMSAQFAGLEFVGVPLRAD------ 141 Query: 178 NTRGEEWTIDFEQFEKAITSKTKAVI-INTPHNPIGKVFTREELTTL-----GNICVKHN 231 +T+D A+ A++ + P+NP G +F ++ + G++C Sbjct: 142 ------FTLDRGAMLAAMAEHQPAIVYLAYPNNPTGNLFDAADMEAIVRAAQGSVC---R 192 Query: 232 VVIISDEVYEHLYFTDSFTRIATLSPEIGQLTL--TVGSAGKSFAATGWRIGWV 283 +++ DE Y+ +R+ + G L + TV G + G R+G+V Sbjct: 193 SLVVVDEAYQPFAQESWMSRLT----DFGNLLVMRTVSKLGLA----GIRLGYV 238 >4C9K-A nrPDB Length = 421 Score = 32.7 bits (73), Expect = 0.29, Method: Compositional matrix adjust. Identities = 15/46 (32%), Positives = 20/46 (43%) Query: 37 LTNEAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDI 82 L NE + N + QGR L +GFF Y P A + D+ Sbjct: 182 LANEMTRPSGNTPEEQGRSLEAANKGFFEYVAPIIAARRGGSGTDL 227 >3NDN-A nrPDB Length = 414 Score = 32.7 bits (73), Expect = 0.30, Method: Compositional matrix adjust. Identities = 26/105 (24%), Positives = 41/105 (39%), Gaps = 13/105 (12%) Query: 121 TTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTR 180 T + + L LL AGD ++ F VV I P + Sbjct: 102 TASGMAAVFTSLGALLGAGDRLVAARSLFGSCF---------VVCSEILPRWGVQTVFVD 152 Query: 181 GEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGN 225 G+ D Q+E+A++ T+AV TP NP+ + +T L + Sbjct: 153 GD----DLSQWERALSVPTQAVFFETPSNPMQSLVDIAAVTELAH 193 >2C81-A nrPDB Length = 418 Score = 32.7 bits (73), Expect = 0.35, Method: Compositional matrix adjust. Identities = 38/159 (23%), Positives = 64/159 (40%), Gaps = 25/159 (15%) Query: 118 VTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINP-PKELDQ 176 V T+G+ +L+ + GDEVIV P++ + +N P +D Sbjct: 61 VPTTSGSTALMLALEALGIGEGDEVIV---------PSLTWIATATAVLNVNALPVFVD- 110 Query: 177 RNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIIS 236 + + ID + + AIT KTKA+I P+ + + + I +HN+ +I Sbjct: 111 --VEADTYCIDPQLIKSAITDKTKAII------PVHLFGSMANMDEINEIAQEHNLFVIE 162 Query: 237 DEVYEHLYF-----TDSFTRIATLSPEIGQLTLTVGSAG 270 D H + I S + G++ LT G G Sbjct: 163 DCAQSHGSVWNNQRAGTIGDIGAFSCQQGKV-LTAGEGG 200 >3HDO-A nrPDB Length = 360 Score = 32.7 bits (73), Expect = 0.37, Method: Compositional matrix adjust. Identities = 47/242 (19%), Positives = 88/242 (36%), Gaps = 30/242 (12%) Query: 118 VTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQR 177 + + G++E + + + G+E+ P + Y E+ G +V Sbjct: 85 IIMANGSDEVLNNLIRAFAAEGEEIGYVHPSYSYYGTLAEVQGARV-------------- 130 Query: 178 NTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISD 237 R T DF + K + TP+ P+G F E + L C +++ D Sbjct: 131 --RTFGLTGDFRIAGFPERYEGKVFFLTTPNAPLGPSFPLEYIDELARRCAG---MLVLD 185 Query: 238 EVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKA 297 E Y +++ + + TL+ KS++ G RIG ++ E++ AA Sbjct: 186 ETYAEFAESNALELVRRHENVVVTRTLS-----KSYSLAGMRIGLAIA-RPEVI--AALD 237 Query: 298 HTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGT 357 R + Q AC ++ D Y + + + FT+ +G +G Sbjct: 238 KIRDHYNLDRLAQAACVAALRDQ---AYLSECCRRIRETREWFTTELRSIGYDVIPSQGN 294 Query: 358 YF 359 Y Sbjct: 295 YL 296 >2CB1-A nrPDB Length = 412 Score = 31.6 bits (70), Expect = 0.74, Method: Compositional matrix adjust. Identities = 29/106 (27%), Positives = 42/106 (39%), Gaps = 25/106 (23%) Query: 139 GDEVIVFEPFFDQYI----PNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKA 194 GDEV+ + F Q I + L G V YV P E +A Sbjct: 95 GDEVVAAKGLFGQTIGLFGQVLSLMGVTVRYVDPEP------------------EAVREA 136 Query: 195 ITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVY 240 +++KT+AV + T NP V E L TL + V ++ D + Sbjct: 137 LSAKTRAVFVETVANPALLVPDLEALATLAE---EAGVALVVDNTF 179 >4W91-A nrPDB Length = 422 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 44/192 (22%), Positives = 73/192 (38%), Gaps = 38/192 (19%) Query: 52 QGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPT-RGRPSLINSLIKLYSPIYN 110 G+ L+ L G S PQ I A N+Y+ RG L N+ Y Sbjct: 36 HGKTLVYLDNGA-SAQKPQSVIDAVTHAY----ANEYANVHRGLHFLSNAATDAYEKSRE 90 Query: 111 TELK------AENVTVTTGANEGILSCLMG----LLNAGDEVIVFEPFFDQYIPNI---- 156 T + + + T A E I + G + GDE+++ ++ NI Sbjct: 91 TVRRFLNAGSVDEIVFTKNATEAINTVAYGYGMPFIGEGDEILLS---IMEHHSNIVPWH 147 Query: 157 ---ELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGK 213 E G K+V+ P++ + E+FEK ++ +TK V I N +G Sbjct: 148 FIRERQGAKLVFTPVD------------DNGVFHIEEFEKRLSERTKLVAITHMSNTLGT 195 Query: 214 VFTREELTTLGN 225 V +++ L + Sbjct: 196 VVPIKKIVELAH 207 >4RAE-A nrPDB Length = 394 Score = 30.4 bits (67), Expect = 1.5, Method: Compositional matrix adjust. Identities = 45/199 (22%), Positives = 74/199 (37%), Gaps = 17/199 (8%) Query: 90 PTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFF 149 P R +L L + +L EN+ G+NE + L G I F P + Sbjct: 69 PDRDAVALRADLAGYLTAQTGIQLGVENIWAANGSNEILQQLLQAFGGPGRSAIGFVPSY 128 Query: 150 DQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHN 209 + P I G ++ E + N G + K V I +P+N Sbjct: 129 SMH-PIIS-DGTHTEWI------EASRANDFG---LDVDVAVAAVVDRKPDVVFIASPNN 177 Query: 210 PIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSA 269 P G+ + +L L ++ + I DE Y S + P +T T+ Sbjct: 178 PSGQSVSLPDLCKLLDVAPG---IAIVDEAYGEFSSQPSAVSLVEEYPSKLVVTRTM--- 231 Query: 270 GKSFAATGWRIGWVLSLNA 288 K+FA G R+G++++ A Sbjct: 232 SKAFAFAGGRLGYLIATPA 250 >3SKS-A nrPDB Length = 567 Score = 30.4 bits (67), Expect = 1.8, Method: Compositional matrix adjust. Identities = 20/72 (27%), Positives = 39/72 (54%), Gaps = 7/72 (9%) Query: 182 EEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVY- 240 E++T+ E+F+ A T + + +I++ I ++ R + T+GN+C + V +D Y Sbjct: 21 EKFTVALEKFDNAKTVEEQKQVIHS----INEI--RNDFGTMGNLCYIRHSVDTTDAFYK 74 Query: 241 EHLYFTDSFTRI 252 E F D F+ + Sbjct: 75 EEQDFFDEFSPV 86 >4ZTY-A nrPDB Length = 769 Score = 29.6 bits (65), Expect = 2.5, Method: Compositional matrix adjust. Identities = 14/36 (38%), Positives = 21/36 (58%), Gaps = 1/36 (2%) Query: 377 EEILNKGKDFRISHWLIN-ELGVVAIPPTEFYIKEH 411 E +L +GK R++HW I + GV IP +F +H Sbjct: 33 EALLAEGKRLRLAHWKIQKDAGVDIIPSNDFAHYDH 68 >2VNA-A nrPDB Length = 357 Score = 28.9 bits (63), Expect = 4.2, Method: Compositional matrix adjust. Identities = 22/64 (34%), Positives = 32/64 (50%), Gaps = 5/64 (7%) Query: 182 EEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYE 241 E + Q+ K K K +IN N +G F + + T GNI +V IS+E+ E Sbjct: 298 EPGILQLSQWFKEGKLKIKETVINGLEN-MGAAF--QSMMTGGNI--GKQIVCISEEIAE 352 Query: 242 HLYF 245 +LYF Sbjct: 353 NLYF 356 >4K8W-A nrPDB Length = 129 Score = 28.9 bits (63), Expect = 4.7, Method: Composition-based stats. Identities = 10/25 (40%), Positives = 15/25 (60%) Query: 349 LPYTAPEGTYFVLVDFSKVKIPEDY 373 PY P GTYF+L D+ + ++ Y Sbjct: 83 FPYKVPTGTYFILNDYREERLDSRY 107 >4PLF-A nrPDB Length = 334 Score = 28.5 bits (62), Expect = 6.8, Method: Compositional matrix adjust. Identities = 16/45 (35%), Positives = 25/45 (55%), Gaps = 1/45 (2%) Query: 37 LTNEAAAKAANNSKNQGRELIN-LGQGFFSYSPPQFAIKEAQKAL 80 +T E + +KN G E++N LGQG ++P AI+ A+ L Sbjct: 213 ITQEEIDEIVERTKNAGGEIVNLLGQGSAYFAPAASAIEMAEAYL 257 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3B46-A nrPDB 565 e-161 3FVS-A nrPDB 363 e-100 4WP0-A nrPDB 362 e-100 2ZJG-A nrPDB 355 2e-98 1YIY-A nrPDB 348 3e-96 1GDE-A nrPDB 342 2e-94 6F77-B nrPDB 337 7e-93 1GC4-A nrPDB 332 2e-91 1J32-A nrPDB 328 3e-90 1O4S-A nrPDB 325 2e-89 6F35-A nrPDB 325 3e-89 1U08-A nrPDB 312 2e-85 5WMH-A nrPDB 312 2e-85 2X5D-A nrPDB 310 6e-85 2Z61-A nrPDB 308 3e-84 1V2E-A nrPDB 300 1e-81 1XI9-A nrPDB 294 4e-80 4MY5-A nrPDB 291 5e-79 2O0R-A nrPDB 288 4e-78 5YHV-A nrPDB 275 3e-74 3H14-A nrPDB 273 1e-73 2O1B-A nrPDB 270 8e-73 3PDX-A nrPDB 264 5e-71 2GB3-A nrPDB 262 3e-70 3DYD-A nrPDB 260 1e-69 4CVQ-A nrPDB 256 2e-68 4IX8-A nrPDB 251 4e-67 3JTX-A nrPDB 250 7e-67 2ZC0-A nrPDB 246 2e-65 3AV7-A nrPDB 235 3e-62 1WST-A nrPDB 235 3e-62 1X0M-A nrPDB 233 1e-61 4DQ6-A nrPDB 232 2e-61 3T32-A nrPDB 232 2e-61 2DOU-A nrPDB 232 3e-61 1BW0-A nrPDB 231 6e-61 3ELE-A nrPDB 228 4e-60 1C7O-A nrPDB 223 1e-58 3L8A-A nrPDB 220 7e-58 3ASB-A nrPDB 218 3e-57 3B1C-A nrPDB 216 1e-56 4FL0-A nrPDB 213 8e-56 3QGU-A nrPDB 210 8e-55 1VP4-A nrPDB 209 2e-54 1M4N-A nrPDB 205 3e-53 3OP7-A nrPDB 204 7e-53 2ZYJ-A nrPDB 200 1e-51 5Z0Q-C nrPDB 199 2e-51 3NRA-A nrPDB 198 6e-51 1IAY-A nrPDB 196 2e-50 3EI8-A nrPDB 196 2e-50 6HNV-A nrPDB 195 3e-50 4GDY-A nrPDB 195 5e-50 3IHJ-A nrPDB 194 7e-50 3DZZ-A nrPDB 189 2e-48 3EZS-A nrPDB 188 5e-48 4JE5-A nrPDB 187 1e-47 6HNB-A nrPDB 186 2e-47 4M2J-A nrPDB 183 2e-46 3TCM-A nrPDB 180 9e-46 3FDB-A nrPDB 180 1e-45 3CQ5-A nrPDB 174 6e-44 3G0T-A nrPDB 167 9e-42 1D2F-A nrPDB 164 6e-41 3FFH-A nrPDB 159 2e-39 3IF2-A nrPDB 159 3e-39 4R2N-A nrPDB 157 1e-38 3G7Q-A nrPDB 146 2e-35 3LY1-A nrPDB 145 4e-35 1IJI-A nrPDB 144 7e-35 1UU1-A nrPDB 143 2e-34 2ZY3-A nrPDB 142 3e-34 2ZY2-A nrPDB 138 7e-33 3FDD-A nrPDB 137 1e-32 3F6T-A nrPDB 132 3e-31 1AY8-A nrPDB 123 2e-28 5DJ3-A nrPDB 109 3e-24 4K2M-A nrPDB 99 4e-21 5WT2-A nrPDB 89 4e-18 3UWC-A nrPDB 79 3e-15 Sequences not found previously or not previously below threshold: 4RAE-A nrPDB 131 8e-31 3HDO-A nrPDB 122 4e-28 3GET-A nrPDB 118 4e-27 3EUC-A nrPDB 114 7e-26 4WBT-A nrPDB 113 2e-25 3RQ1-A nrPDB 108 4e-24 3FTB-A nrPDB 106 2e-23 1LC8-A nrPDB 102 4e-22 2X5F-A nrPDB 99 4e-21 5X03-B nrPDB 99 4e-21 4N0B-A nrPDB 98 1e-20 4EMY-A nrPDB 96 2e-20 3FKD-A nrPDB 95 5e-20 4F5M-A nrPDB 94 1e-19 3FSL-A nrPDB 94 2e-19 3P1T-A nrPDB 88 8e-18 3PD6-B nrPDB 84 1e-16 4WD2-A nrPDB 84 1e-16 5IWQ-A nrPDB 84 1e-16 6C3C-A nrPDB 79 3e-15 6EZL-A nrPDB 79 5e-15 3BWN-A nrPDB 78 6e-15 4WB0-B nrPDB 78 8e-15 4RKC-A nrPDB 78 8e-15 4W5K-A nrPDB 78 1e-14 4EFF-A nrPDB 76 2e-14 3NYS-A nrPDB 76 3e-14 2CST-A nrPDB 76 4e-14 3DR4-A nrPDB 75 7e-14 4H51-A nrPDB 75 7e-14 1YAA-A nrPDB 74 9e-14 2C81-A nrPDB 73 2e-13 1TAR-A nrPDB 73 2e-13 3II0-A nrPDB 73 2e-13 2OGE-A nrPDB 73 3e-13 3EZ1-A nrPDB 73 3e-13 3MEB-A nrPDB 73 3e-13 2X8U-A nrPDB 71 1e-12 1M6S-A nrPDB 71 1e-12 1MDZ-A nrPDB 70 2e-12 2HOR-A nrPDB 69 4e-12 4PIW-A nrPDB 69 5e-12 5TON-A nrPDB 69 5e-12 5W1B-A nrPDB 68 9e-12 5XT5-A nrPDB 68 1e-11 6BLG-A nrPDB 65 5e-11 5K8B-A nrPDB 65 8e-11 4W91-A nrPDB 64 1e-10 1B9H-A nrPDB 64 1e-10 5C6U-A nrPDB 64 2e-10 3K7Y-A nrPDB 63 2e-10 4OC9-A nrPDB 63 3e-10 3VK2-A nrPDB 62 4e-10 5W70-A nrPDB 61 7e-10 3A2B-A nrPDB 61 1e-09 3BB8-A nrPDB 59 4e-09 3MKJ-A nrPDB 58 6e-09 4LW2-A nrPDB 58 6e-09 3QI6-A nrPDB 58 8e-09 1O69-A nrPDB 58 9e-09 1ECX-A nrPDB 57 2e-08 2GMS-A nrPDB 57 2e-08 4BMK-A nrPDB 56 3e-08 5VPR-A nrPDB 56 4e-08 3TQX-A nrPDB 56 4e-08 6CJB-A nrPDB 56 5e-08 3AEO-A nrPDB 55 6e-08 3LVM-A nrPDB 54 1e-07 1T3I-A nrPDB 54 1e-07 1CS1-A nrPDB 54 1e-07 4JF0-A nrPDB 54 1e-07 6HRH-B nrPDB 53 2e-07 5U24-A nrPDB 53 2e-07 5TSU-A nrPDB 53 2e-07 5VMB-A nrPDB 53 2e-07 2E7J-A nrPDB 53 3e-07 4IYO-A nrPDB 53 3e-07 5WGB-A nrPDB 53 3e-07 5DX5-A nrPDB 53 3e-07 1E5F-A nrPDB 53 4e-07 6ONN-A nrPDB 52 5e-07 4Q6R-A nrPDB 52 7e-07 4ADC-A nrPDB 52 7e-07 1N8P-A nrPDB 51 8e-07 5X5H-A nrPDB 51 9e-07 4QGR-A nrPDB 51 1e-06 2EZ1-A nrPDB 51 1e-06 5YKR-A nrPDB 51 1e-06 1C7G-A nrPDB 51 1e-06 4L0O-H nrPDB 51 1e-06 3WGB-A nrPDB 50 2e-06 1FC4-A nrPDB 50 2e-06 2CTZ-A nrPDB 49 3e-06 5JAY-A nrPDB 49 4e-06 3MAF-B nrPDB 49 6e-06 5I92-A nrPDB 48 8e-06 2BWN-A nrPDB 48 8e-06 4ZWV-A nrPDB 48 9e-06 4GSA-A nrPDB 48 9e-06 4P3M-A nrPDB 47 1e-05 5TXT-B nrPDB 47 1e-05 3G8M-A nrPDB 47 1e-05 3WKR-A nrPDB 47 2e-05 2DKJ-A nrPDB 46 3e-05 4J5U-A nrPDB 46 3e-05 1IBJ-A nrPDB 46 4e-05 3GBX-A nrPDB 46 4e-05 3NDN-A nrPDB 46 4e-05 2DR1-A nrPDB 45 6e-05 3ISL-A nrPDB 45 7e-05 3HMU-A nrPDB 44 9e-05 3N0L-A nrPDB 44 1e-04 2CB1-A nrPDB 44 1e-04 1WYV-B nrPDB 44 1e-04 5IJG-A nrPDB 44 2e-04 4OBV-D nrPDB 44 2e-04 4U1T-A nrPDB 43 2e-04 3NNK-A nrPDB 43 2e-04 2E54-A nrPDB 43 2e-04 3RUY-A nrPDB 43 3e-04 5LL2-A nrPDB 43 3e-04 4J8L-A nrPDB 43 3e-04 2EH6-A nrPDB 42 6e-04 5Z0Y-A nrPDB 42 7e-04 4OTL-A nrPDB 41 8e-04 4W8I-A nrPDB 41 0.001 2EO5-A nrPDB 41 0.001 3A9Z-A nrPDB 41 0.001 3GZD-A nrPDB 41 0.002 1SVV-A nrPDB 40 0.002 3WY7-A nrPDB 40 0.002 2E7U-A nrPDB 40 0.002 3ECD-A nrPDB 39 0.003 3GJU-A nrPDB 39 0.006 4KAM-A nrPDB 39 0.006 1Z7D-A nrPDB 38 0.007 1SFF-A nrPDB 38 0.007 6JEQ-A nrPDB 38 0.009 3MC6-C nrPDB 38 0.010 2FNU-A nrPDB 38 0.010 3NTJ-A nrPDB 37 0.013 5VYE-A nrPDB 37 0.014 3RI6-A nrPDB 37 0.017 3I5T-A nrPDB 37 0.018 3HQT-A nrPDB 37 0.020 2VYC-A nrPDB 37 0.020 5LH9-A nrPDB 37 0.021 5M46-A nrPDB 37 0.021 3HBX-A nrPDB 36 0.029 2QMA-A nrPDB 36 0.029 1VJO-A nrPDB 36 0.033 4ISY-A nrPDB 36 0.038 3HL2-A nrPDB 36 0.051 3FCR-A nrPDB 35 0.053 4PPM-A nrPDB 35 0.056 3L44-A nrPDB 35 0.063 3BC8-A nrPDB 35 0.080 6G4F-A nrPDB 35 0.081 6GWI-A nrPDB 35 0.086 4E3Q-A nrPDB 34 0.096 4WXB-A nrPDB 34 0.099 5KR3-A nrPDB 34 0.10 5VIU-A nrPDB 34 0.11 4RIT-B nrPDB 34 0.13 2CH1-A nrPDB 34 0.13 2Z9W-A nrPDB 34 0.14 4BA4-A nrPDB 34 0.14 5KQU-A nrPDB 34 0.15 1DJ9-A nrPDB 34 0.17 2DGM-A nrPDB 34 0.19 5KQW-A nrPDB 34 0.20 5KR5-A nrPDB 33 0.23 2HUU-A nrPDB 33 0.24 1OAT-A nrPDB 33 0.27 5KR6-A nrPDB 32 0.35 5EG1-A nrPDB 32 0.36 2Z67-A nrPDB 32 0.36 3DOR-A nrPDB 32 0.47 6ERK-A nrPDB 32 0.49 5FXF-A nrPDB 32 0.66 2JIS-A nrPDB 32 0.68 5XX1-A nrPDB 32 0.73 1QZ9-A nrPDB 32 0.73 3N5M-A nrPDB 31 0.78 1S09-A nrPDB 31 0.78 4GRX-A nrPDB 31 0.80 5KQT-A nrPDB 31 0.81 2ZUK-A nrPDB 31 0.87 2YWH-A nrPDB 31 0.94 6IO1-A nrPDB 31 1.0 5O5C-A nrPDB 31 1.0 6GIO-D nrPDB 31 1.3 6JRL-A nrPDB 31 1.3 5GHG-A nrPDB 31 1.4 2OKJ-A nrPDB 31 1.5 1OHW-A nrPDB 31 1.5 4BQ0-A nrPDB 30 1.9 3DR3-A nrPDB 30 1.9 4ROS-A nrPDB 30 2.0 4E1O-A nrPDB 30 2.1 6EEI-A nrPDB 30 2.3 1VRD-A nrPDB 30 2.5 5VNX-A nrPDB 29 3.0 2E8Y-A nrPDB 29 3.9 4WYG-A nrPDB 29 4.1 1WA5-C nrPDB 29 4.3 4W8Y-A nrPDB 29 4.6 2BHU-A nrPDB 29 5.2 5EAV-A nrPDB 29 5.8 3TL2-A nrPDB 28 6.9 2C8J-A nrPDB 28 7.9 6EEW-A nrPDB 28 8.5 6GPA-A nrPDB 28 9.3 6GP5-A nrPDB 28 9.3 4UHN-A nrPDB 28 9.7 >3B46-A nrPDB Length = 447 Score = 565 bits (1456), Expect = e-161, Method: Composition-based stats. Identities = 444/444 (100%), Positives = 444/444 (100%) Query: 1 MKQRFIRQFTNLMSTSRPKVVANKYFTSNTAKDVWSLTNEAAAKAANNSKNQGRELINLG 60 MKQRFIRQFTNLMSTSRPKVVANKYFTSNTAKDVWSLTNEAAAKAANNSKNQGRELINLG Sbjct: 4 MKQRFIRQFTNLMSTSRPKVVANKYFTSNTAKDVWSLTNEAAAKAANNSKNQGRELINLG 63 Query: 61 QGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTV 120 QGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTV Sbjct: 64 QGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTV 123 Query: 121 TTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTR 180 TTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTR Sbjct: 124 TTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTR 183 Query: 181 GEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVY 240 GEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVY Sbjct: 184 GEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVY 243 Query: 241 EHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTR 300 EHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTR Sbjct: 244 EHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTR 303 Query: 301 ICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFV 360 ICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFV Sbjct: 304 ICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFV 363 Query: 361 LVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLR 420 LVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLR Sbjct: 364 LVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLR 423 Query: 421 FAVCKDDAYLENAVERLKLLKDYL 444 FAVCKDDAYLENAVERLKLLKDYL Sbjct: 424 FAVCKDDAYLENAVERLKLLKDYL 447 >3FVS-A nrPDB Length = 422 Score = 363 bits (931), Expect = e-100, Method: Composition-based stats. Identities = 137/396 (34%), Positives = 211/396 (53%), Gaps = 12/396 (3%) Query: 54 RELINLGQGFFSYSPPQFAIKEAQKALDIP-MVNQYSPTRGRPSLINSLIKLYSPIYNTE 112 +++NLGQGF + PP FA++ Q A+ M+NQY+ T G P L L + + E Sbjct: 28 HDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFMLNQYTKTFGYPPLTKILASFFGELLGQE 87 Query: 113 LKA-ENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPP 171 + NV VT G + + L++ GDEVI+ EPFFD Y P + GG+ V+V + P Sbjct: 88 IDPLRNVLVTVGGYGALFTAFQALVDEGDEVIIIEPFFDCYEPMTMMAGGRPVFVSLKPG 147 Query: 172 KELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHN 231 + W +D + TS+TKA+++NTP+NP+GKVF+REEL + ++C +H+ Sbjct: 148 PIQNGELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVFSREELELVASLCQQHD 207 Query: 232 VVIISDEVYEHLYFT-DSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAEL 290 VV I+DEVY+ + + IA+L P + + TLT+GSAGK+F+ATGW++GWVL + + Sbjct: 208 VVCITDEVYQWMVYDGHQHISIASL-PGMWERTLTIGSAGKTFSATGWKVGWVLGPD-HI 265 Query: 291 LSYAAKAHTRICFASPSPLQEACANSINDALKI-----GYFEKMRQEYINKFKIFTSIFD 345 + + H F P+ Q A A S + YF + Q Sbjct: 266 MKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFRQPSSYFVQFPQAMQRCRDHMIRSLQ 325 Query: 346 ELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTE 405 +GL P+G+YF++ D S K P +++ D R W+I G+VAIP + Sbjct: 326 SVGLKPIIPQGSYFLITDISDFK--RKMPDLPGAVDEPYDRRFVKWMIKNKGLVAIPVSI 383 Query: 406 FYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLK 441 FY H+K ++ +RF KD+A L+ E+L+ K Sbjct: 384 FYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWK 419 >4WP0-A nrPDB Length = 472 Score = 362 bits (930), Expect = e-100, Method: Composition-based stats. Identities = 137/396 (34%), Positives = 211/396 (53%), Gaps = 12/396 (3%) Query: 54 RELINLGQGFFSYSPPQFAIKEAQKALDIP-MVNQYSPTRGRPSLINSLIKLYSPIYNTE 112 +++NLGQGF + PP FA++ Q A+ M+NQY+ T G P L L + + E Sbjct: 28 HDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFMLNQYTKTFGYPPLTKILASFFGELLGQE 87 Query: 113 LKA-ENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPP 171 + NV VT G + + L++ GDEVI+ EPFFD Y P + GG+ V+V + P Sbjct: 88 IDPLRNVLVTVGGYGALFTAFQALVDEGDEVIIIEPFFDCYEPMTMMAGGRPVFVSLKPG 147 Query: 172 KELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHN 231 + W +D + TS+TKA+++NTP+NP+GKVF+REEL + ++C +H+ Sbjct: 148 PIQNGELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVFSREELELVASLCQQHD 207 Query: 232 VVIISDEVYEHLYFT-DSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAEL 290 VV I+DEVY+ + + IA+L P + + TLT+GSAGK+F+ATGW++GWVL + + Sbjct: 208 VVCITDEVYQWMVYDGHQHISIASL-PGMWERTLTIGSAGKTFSATGWKVGWVLGPD-HI 265 Query: 291 LSYAAKAHTRICFASPSPLQEACANSINDALKI-----GYFEKMRQEYINKFKIFTSIFD 345 + + H F P+ Q A A S + YF + Q Sbjct: 266 MKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFRQPSSYFVQFPQAMQRCRDHMIRSLQ 325 Query: 346 ELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTE 405 +GL P+G+YF++ D S K P +++ D R W+I G+VAIP + Sbjct: 326 SVGLKPIIPQGSYFLITDISDFK--RKMPDLPGAVDEPYDRRFVKWMIKNKGLVAIPVSI 383 Query: 406 FYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLK 441 FY H+K ++ +RF KD+A L+ E+L+ K Sbjct: 384 FYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWK 419 >2ZJG-A nrPDB Length = 410 Score = 355 bits (911), Expect = 2e-98, Method: Composition-based stats. Identities = 130/391 (33%), Positives = 206/391 (52%), Gaps = 12/391 (3%) Query: 56 LINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKA 115 ++NLGQGF SPP + +E KA I +NQY+ G P+L+ +L LY IY ++ Sbjct: 25 VVNLGQGFPDISPPSYVKEELSKAAFIDNMNQYTRGFGHPALVKALSCLYGKIYQRQIDP 84 Query: 116 -ENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKEL 174 E + V GA + + + GL++ GDEVI+ PF+D Y P + + G V++P+ K Sbjct: 85 NEEILVAVGAYGSLFNSIQGLVDPGDEVIIMVPFYDCYEPMVRMAGAVPVFIPLR-SKPT 143 Query: 175 DQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVI 234 D +WT D + E +SKTKA+I+NTPHNP+GKV+TR+EL + ++CVKH+ + Sbjct: 144 DGMKWTSSDWTFDPRELESKFSSKTKAIILNTPHNPLGKVYTRQELQVIADLCVKHDTLC 203 Query: 235 ISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYA 294 ISDEVYE L +T P + + T+T+GSAGK+F+ TGW++GW + A L+ + Sbjct: 204 ISDEVYEWLVYTGHTHVKIATLPGMWERTITIGSAGKTFSVTGWKLGWSIGP-AHLIKHL 262 Query: 295 AKAHTRICFASPSPLQEACANSINDALKI-----GYFEKMRQEYINKFKIFTSIFDELGL 349 + +PLQ A A + +K YF + +E K + + +GL Sbjct: 263 QTVQQNSFYTCATPLQAALAEAFWIDIKRMDDPECYFNSLPKELEVKRDRMVRLLNSVGL 322 Query: 350 PYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIK 409 P+G YF++ D S + + ++ D++ W+ + AIP + F Sbjct: 323 KPIVPDGGYFIIADVSSLG----ADLSDMNSDEPYDYKFVKWMTKHKKLTAIPVSAFCDS 378 Query: 410 EHEKAAENLLRFAVCKDDAYLENAVERLKLL 440 + + E L+RF K D+ L+ A E + Sbjct: 379 KSKPHFEKLVRFCFIKKDSTLDAAEEIFRAW 409 >1YIY-A nrPDB Length = 429 Score = 348 bits (892), Expect = 3e-96, Method: Composition-based stats. Identities = 152/442 (34%), Positives = 229/442 (51%), Gaps = 29/442 (6%) Query: 13 MSTSRPKVVANKYFTSN----TAKDVWSLTNEAAAKAANNSKNQGRELINLGQGFFSYSP 68 MS++ + + NK+ + K VW + AA+ + +NLGQGF Y Sbjct: 1 MSSTSNETMHNKFDLPKRYQGSTKSVWVEYIQLAAQ---------YKPLNLGQGFPDYHA 51 Query: 69 PQFAIKEAQKALDIP--MVNQYSPTRGRPSLINSLIKLYSPIYNTELKAE-NVTVTTGAN 125 P++A+ A + P + NQY+ G P L+ +L KLYS + + + V VT GA Sbjct: 52 PKYALNALAAAANSPDPLANQYTRGFGHPRLVQALSKLYSQLVDRTINPMTEVLVTVGAY 111 Query: 126 EGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWT 185 E + + + G ++ GDEVI+ EPFFD Y P ++ GG ++P+ P K +W Sbjct: 112 EALYATIQGHVDEGDEVIIIEPFFDCYEPMVKAAGGIPRFIPLKPNKT--GGTISSADWV 169 Query: 186 IDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYF 245 +D + E KTK +IINTPHNP+GKV R EL + N+C K NV+ +SDEVYEH+ F Sbjct: 170 LDNNELEALFNEKTKMIIINTPHNPLGKVMDRAELEVVANLCKKWNVLCVSDEVYEHMVF 229 Query: 246 TD-SFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFA 304 RI TL P + + T+T+GSAGK+F+ TGW+IGW A LL H + Sbjct: 230 EPFEHIRICTL-PGMWERTITIGSAGKTFSLTGWKIGWAYGPEA-LLKNLQMVHQNCVYT 287 Query: 305 SPSPLQEACANSINDALKI-----GYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYF 359 +P+QEA A LK YF + E + K S E+G+ T P+G YF Sbjct: 288 CATPIQEAIAVGFETELKRLKSPECYFNSISGELMAKRDYMASFLAEVGMNPTVPQGGYF 347 Query: 360 VLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLL 419 ++ D+S + D + + KD+R + W+ +G+ IPP+ FY + ++ E+ + Sbjct: 348 MVADWSSLDSKVDL---TQETDARKDYRFTKWMTKSVGLQGIPPSAFYSEPNKHLGEDFV 404 Query: 420 RFAVCKDDAYLENAVERLKLLK 441 R+ K D L+ A E L+ K Sbjct: 405 RYCFFKKDENLQKAAEILRKWK 426 >1GDE-A nrPDB Length = 389 Score = 342 bits (876), Expect = 2e-94, Method: Composition-based stats. Identities = 107/392 (27%), Positives = 188/392 (47%), Gaps = 33/392 (8%) Query: 54 RELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTEL 113 +++I+LG G + PQ + A++ALD + + Y P G L ++ + E Sbjct: 26 KDVISLGIGEPDFDTPQHIKEYAKEALDKGLTH-YGPNIGLLELREAIAEKLKKQNGIEA 84 Query: 114 KAE-NVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPK 172 + + V GAN+ L L L G+EV++ P F Y P + L GGK V VP Sbjct: 85 DPKTEIMVLLGANQAFLMGLSAFLKDGEEVLIPTPAFVSYAPAVILAGGKPVEVP----- 139 Query: 173 ELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNV 232 +E+ ++ ++ +K +T KT+A+IIN+P NP G V T+++L + + V+H++ Sbjct: 140 -----TYEEDEFRLNVDELKKYVTDKTRALIINSPCNPTGAVLTKKDLEEIADFVVEHDL 194 Query: 233 VIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLS 292 ++ISDEVYEH + D+ + + T+TV K+FA TGWR+G+V + + ++ Sbjct: 195 IVISDEVYEHFIYDDARHYSIASLDGMFERTITVNGFSKTFAMTGWRLGFVAAPSW-IIE 253 Query: 293 YAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYT 352 K + +Q A A ++ D E+MR+EY + K+ +E+GLP Sbjct: 254 RMVKFQMYNATCPVTFIQYAAAKALKDERSWKAVEEMRKEYDRRRKLVWKRLNEMGLPTV 313 Query: 353 APEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHE 412 P+G +++ + + S ++ E V +P + F Sbjct: 314 KPKGAFYIFPRIRDTGLTSK--------------KFSELMLKEARVAVVPGSAFG----- 354 Query: 413 KAAENLLRFAVCKDDAYLENAVERL-KLLKDY 443 KA E +R + LE A++R+ ++LK+ Sbjct: 355 KAGEGYVRISYATAYEKLEEAMDRMERVLKER 386 >6F77-B nrPDB Length = 400 Score = 337 bits (863), Expect = 7e-93, Method: Composition-based stats. Identities = 106/419 (25%), Positives = 186/419 (44%), Gaps = 28/419 (6%) Query: 26 FTSNTAKDVWSLTNEAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMV 85 F ++ V A ++ A K +GR++I LG G + P K A A+D Sbjct: 3 FLADALSRVKPSATIAVSQKARELKAKGRDVIGLGAGEPDFDTPDNIKKAAIDAIDRGET 62 Query: 86 NQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVF 145 +Y+P G P L ++ K + N + A V TG + + + M LN GDEV++ Sbjct: 63 -KYTPVSGIPELREAIAKKFKRENNLDYTAAQTIVGTGGKQILFNAFMATLNPGDEVVIP 121 Query: 146 EPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIIN 205 P++ Y + LCGG V+VP + + E ++AIT KTK + N Sbjct: 122 APYWVSYPEMVALCGGTPVFVPTRQEN----------NFKLKAEDLDRAITPKTKWFVFN 171 Query: 206 TPHNPIGKVFTREELTTLGNICVKH-NVVIISDEVYEHLYFTD-SFTRIATLSPEIGQLT 263 +P NP G ++ EEL L ++ +KH +V +++D++YEHL + D F + P + + T Sbjct: 172 SPSNPSGAAYSHEELKALTDVLMKHPHVWVLTDDMYEHLTYGDFRFATPVEVEPGLYERT 231 Query: 264 LTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKI 323 LT+ K++A TGWRIG+ L+ + + S Q A ++N Sbjct: 232 LTMNGVSKAYAMTGWRIGYAAGP-LHLIKAMDMIQGQQTSGAASIAQWAAVEALNGPQD- 289 Query: 324 GYFEKMRQEYINKFKIFTSIFDEL-GLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNK 382 + + ++ + + + S+ ++ G+ PEG ++V + + I + P + I Sbjct: 290 -FIGRNKEIFQGRRDLVVSMLNQAKGISCPTPEGAFYVYPSCAGL-IGKTAPSGKVIET- 346 Query: 383 GKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLK 441 D L+ GV + + F + + R + +A LE A R++ Sbjct: 347 --DEDFVSELLETEGVAVVHGSAFGLGPN-------FRISYATSEALLEEACRRIQRFC 396 >1GC4-A nrPDB Length = 385 Score = 332 bits (851), Expect = 2e-91, Method: Composition-based stats. Identities = 110/401 (27%), Positives = 179/401 (44%), Gaps = 38/401 (9%) Query: 41 AAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINS 100 A A + QG +L+ L G + P+ + A++AL +Y+P G P L + Sbjct: 18 AVNAKALELRRQGVDLVALTAGEPDFDTPEHVKEAARRALAQGKT-KYAPPAGIPELREA 76 Query: 101 LIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCG 160 L + + + E VT G ++ + + +L+ GDEVIV P++ Y + G Sbjct: 77 LAEKFRRENGLSVTPEETIVTVGGSQALFNLFQAILDPGDEVIVLSPYWVSYPEMVRFAG 136 Query: 161 GKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREEL 220 G VV V P E + D E+ +AIT +TKA+++N+P+NP G V+ +E L Sbjct: 137 GVVVEVETLPE----------EGFVPDPERVRRAITPRTKALVVNSPNNPTGAVYPKEVL 186 Query: 221 TTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRI 280 L + V+H+ ++SDE+YEHL + ++PE TLTV A K+FA TGWRI Sbjct: 187 EALARLAVEHDFYLVSDEIYEHLLYEGEHFSPGRVAPE---HTLTVNGAAKAFAMTGWRI 243 Query: 281 GWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSI-NDALKIGYFEKMRQEYINKFKI 339 G+ E++ A + + + Q A ++ N + E R+ Y + + Sbjct: 244 GYACGP-KEVIKAMASVSRQSTTSPDTIAQWATLEALTNQEASRAFVEMAREAYRRRRDL 302 Query: 340 FTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVV 399 LGL P G ++VL+D S + D + + E GV Sbjct: 303 LLEGLTALGLKAVRPSGAFYVLMDTSPI---------------APDEVRAAERLLEAGVA 347 Query: 400 AIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLL 440 +P T+F AA +R + + L A+ER + Sbjct: 348 VVPGTDF-------AAFGHVRLSYATSEENLRKALERFARV 381 >1J32-A nrPDB Length = 388 Score = 328 bits (840), Expect = 3e-90, Method: Composition-based stats. Identities = 91/406 (22%), Positives = 176/406 (43%), Gaps = 40/406 (9%) Query: 36 SLTNEAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRP 95 +L +A AKA K +G ++ + G ++ P+ ++ A+ AL+ +Y P G P Sbjct: 15 TLIIDAKAKAM---KAEGIDVCSFSAGEPDFNTPKHIVEAAKAALEQGKT-RYGPAAGEP 70 Query: 96 SLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPN 155 L ++ + A+N+ VT G + I + ++ ++ GDEVI+ PF+ Y Sbjct: 71 RLREAIAQKLQRDNGLCYGADNILVTNGGKQSIFNLMLAMIEPGDEVIIPAPFWVSYPEM 130 Query: 156 IELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVF 215 ++L G V +P T ++ + EQ +AIT KTK ++ NTP NP G V+ Sbjct: 131 VKLAEGTPVILP----------TTVETQFKVSPEQIRQAITPKTKLLVFNTPSNPTGMVY 180 Query: 216 TREELTTLGNICVKHNVVIISDEVYEHLYFTD-SFTRIATLSPEIGQLTLTVGSAGKSFA 274 T +E+ + + V+ + ++SDE+YE + + D I SPE + ++ K++A Sbjct: 181 TPDEVRAIAQVAVEAGLWVLSDEIYEKILYDDAQHLSIGAASPEAYERSVVCSGFAKTYA 240 Query: 275 ATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYI 334 TGWR+G++ L+ A K + Q + ++ ++M + Sbjct: 241 MTGWRVGFLAGPVP-LVKAATKIQGHSTSNVCTFAQYGAIAAYENSQDC--VQEMLAAFA 297 Query: 335 NKFKIFTSIFDEL-GLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLI 393 + + + + GL P+G +++ +K L+ Sbjct: 298 ERRRYMLDALNAMPGLECPKPDGAFYMFPSIAKTG--------------RSSLDFCSELL 343 Query: 394 NELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKL 439 ++ V +P F A++ +R + D ++ +ERL+ Sbjct: 344 DQHQVATVPGAAF-------GADDCIRLSYATDLDTIKRGMERLEK 382 >1O4S-A nrPDB Length = 389 Score = 325 bits (834), Expect = 2e-89, Method: Composition-based stats. Identities = 112/409 (27%), Positives = 178/409 (43%), Gaps = 46/409 (11%) Query: 36 SLTNEAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRP 95 S T E AKA K +G ++INL G + P+ ++EA + L V +Y+ RG Sbjct: 24 SKTMELDAKAKALIK-KGEDVINLTAGEPDFPTPEPVVEEAVRFLQKGEV-KYTDPRGIY 81 Query: 96 SLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPN 155 L + K Y ++ + V VT GA + + + M LL+ GDEVIVF P + YIP Sbjct: 82 ELREGIAKRIGERYKKDISPDQVVVTNGAKQALFNAFMALLDPGDEVIVFSPVWVSYIPQ 141 Query: 156 IELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVF 215 I L GG V V + + E+ E + KTKAV+IN+P+NP G V+ Sbjct: 142 IILAGGTVNVV----------ETFMSKNFQPSLEEVEGLLVGKTKAVLINSPNNPTGVVY 191 Query: 216 TREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAA 275 RE L L + K N IISDEVY+ L +TD FT I +S + + KS + Sbjct: 192 RREFLEGLVRLAKKRNFYIISDEVYDSLVYTDEFTSILDVSEGF-DRIVYINGFSKSHSM 250 Query: 276 TGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYIN 335 TGWR+G+++S + + +K + + Q A ++ M Q + Sbjct: 251 TGWRVGYLISSEK-VATAVSKIQSHTTSCINTVAQYAALKALEVDNSY-----MVQTFKE 304 Query: 336 KFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINE 395 + ++G+ + PEG +++ +G D + L+ E Sbjct: 305 RKNFVVERLKKMGVKFVEPEGAFYLFFKV-----------------RGDDVKFCERLLEE 347 Query: 396 LGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLKDYL 444 V +P + F +R + L A++R++ D+L Sbjct: 348 KKVALVPGSAFLKP-------GFVRLSFATSIERLTEALDRIE---DFL 386 >6F35-A nrPDB Length = 410 Score = 325 bits (832), Expect = 3e-89, Method: Composition-based stats. Identities = 95/402 (23%), Positives = 180/402 (44%), Gaps = 28/402 (6%) Query: 46 ANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLY 105 A K +G+ +I LG G + P+ + A A+ +Y+ G P L ++ + + Sbjct: 33 AAAMKREGKPVIILGAGEPDFDTPEHVKQAASDAIHRGET-KYTALDGTPELKKAIREKF 91 Query: 106 SPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVY 165 + + +TV TGA + + + +M L+ GDEVI+ P++ Y + +C GK V Sbjct: 92 QRENGLAYELDEITVATGAKQILFNAMMASLDPGDEVIIPTPYWTSYSDIVHICEGKPVL 151 Query: 166 VPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGN 225 + + + + E+ E AIT +T+ V++N+P NP G ++ + L Sbjct: 152 IACDA----------SSGFRLTAEKLEAAITPRTRWVLLNSPSNPSGAAYSAADYRPLLE 201 Query: 226 ICVKH-NVVIISDEVYEHLYFTD-SFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWV 283 + ++H +V ++ D++YEH+ + F A L P + TLTV K++A TGWRIG+ Sbjct: 202 VLLRHPHVWLLVDDMYEHIVYDGFRFVTPAQLEPGLKNRTLTVNGVSKAYAMTGWRIGYA 261 Query: 284 LSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSI 343 EL+ A ++ S Q A ++N + ++ + + + + + Sbjct: 262 GGPR-ELIKAMAVVQSQATSCPSSISQAASVVALNGPQD--FLKERTESFQRRRDLVVNG 318 Query: 344 FDEL-GLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIP 402 + + GL PEG ++ + V + + P + I D +L+ + V +P Sbjct: 319 LNAIDGLDCRVPEGAFYTFSGCAGV-LGKVTPSGKRI---KTDTDFCAYLLEDAHVAVVP 374 Query: 403 PTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLKDYL 444 + F + R + +A L+ A+ER+ D L Sbjct: 375 GSAFGLSP-------FFRISYATSEAELKEALERIAAACDRL 409 >1U08-A nrPDB Length = 386 Score = 312 bits (800), Expect = 2e-85, Method: Composition-based stats. Identities = 114/391 (29%), Positives = 187/391 (47%), Gaps = 32/391 (8%) Query: 51 NQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYN 110 Q + INL QGF + P++ + + NQY+P G +L ++ + +Y Sbjct: 27 AQQHQAINLSQGFPDFDGPRYLQERLAHHV-AQGANQYAPMTGVQALREAIAQKTERLYG 85 Query: 111 TELKAE-NVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPIN 169 + A+ ++TVT GA E + + + L+ GDEVI F+P +D Y P I L GG V + + Sbjct: 86 YQPDADSDITVTAGATEALYAAITALVRNGDEVICFDPSYDSYAPAIALSGGIVKRMALQ 145 Query: 170 PPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVK 229 PP + +D+++F ++ +T+ VI+NTPHNP V+ + + L Sbjct: 146 PP-----------HFRVDWQEFAALLSERTRLVILNTPHNPSATVWQQADFAALWQAIAG 194 Query: 230 HNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAE 289 H + +ISDEVYEH+ F+ P++ + + V S GK++ TGW++G+ ++ A Sbjct: 195 HEIFVISDEVYEHINFSQQGHASVLAHPQLRERAVAVSSFGKTYHMTGWKVGYCVAP-AP 253 Query: 290 LLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGL 349 + + K H + F+ +P Q A A+ + + ++ + Y K I + +E L Sbjct: 254 ISAEIRKVHQYLTFSVNTPAQLALADMLR--AEPEHYLALPDFYRQKRDILVNALNESRL 311 Query: 350 PYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIK 409 EGTYF+LVD+S V + D WL E GV AIP + F Sbjct: 312 EILPCEGTYFLLVDYSAVSTLD-------------DVEFCQWLTQEHGVAAIPLSVFCAD 358 Query: 410 EHEKAAENLLRFAVCKDDAYLENAVERLKLL 440 L+R K ++ L A ERL+ L Sbjct: 359 PFP---HKLIRLCFAKKESTLLAAAERLRQL 386 >5WMH-A nrPDB Length = 475 Score = 312 bits (799), Expect = 2e-85, Method: Composition-based stats. Identities = 81/402 (20%), Positives = 166/402 (41%), Gaps = 26/402 (6%) Query: 46 ANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLY 105 A G +I L G + P+ + A+ +Y+ G L ++ + Sbjct: 91 AATLVQSGVPVIRLAAGEPDFDTPKVVAEAGINAIREG-FTRYTLNAGITELREAICRKL 149 Query: 106 SPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVY 165 + + V+ GA + +L ++ + + GDEVI+ P++ Y L V Sbjct: 150 KEENGLSYAPDQILVSNGAKQSLLQAVLAVCSPGDEVIIPAPYWVSYTEQARLADATPVV 209 Query: 166 VPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGN 225 +P + +D + E +T K++ +I+ +P NP G V+ + L + Sbjct: 210 IP----------TKISNNFLLDPKDLESKLTEKSRLLILCSPSNPTGSVYPKSLLEEIAR 259 Query: 226 ICVKH-NVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVL 284 I KH ++++SDE+YEH+ + + P++ + TLTV K+FA TGWR+G++ Sbjct: 260 IIAKHPRLLVLSDEIYEHIIYAPATHTSFASLPDMYERTLTVNGFSKAFAMTGWRLGYLA 319 Query: 285 SLNAELLSYAAKAHTRICFASPSPLQEACANSIN-DALKIGYFEKMRQEYINKFKIFTSI 343 +++ +K ++ + S Q+A ++ +M + Y + Sbjct: 320 GP-KHIVAACSKLQGQVSSGASSIAQKAGVAALGLGKAGGETVAEMVKAYRERRDFLVKS 378 Query: 344 F-DELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIP 402 D G+ + P+G +++ +DFS E E ++ + +++ V +P Sbjct: 379 LGDIKGVKISEPQGAFYLFIDFSAYYGSE----AEGFGLINDSSSLALYFLDKFQVAMVP 434 Query: 403 PTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLKDYL 444 F + +R + L+ AVE+++ + L Sbjct: 435 GDAFGDD-------SCIRISYATSLDVLQAAVEKIRKALEPL 469 >2X5D-A nrPDB Length = 412 Score = 310 bits (795), Expect = 6e-85, Method: Composition-based stats. Identities = 81/407 (19%), Positives = 164/407 (40%), Gaps = 37/407 (9%) Query: 38 TNEAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSL 97 A+ ++ +G ++I+L G P +++ + YS +RG P L Sbjct: 21 VFNITAELKMAARRRGEDIIDLSMGNPDGPTPPHIVEKLCTVAQREDTHGYSTSRGIPRL 80 Query: 98 INSLIKLYSPIYNTELKAE-NVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNI 156 ++ Y Y+ ++ E VT G+ EG+ ++ L+ GD ++V P + +I Sbjct: 81 RRAISHWYRDRYDVQIDPESEAIVTIGSKEGLAHLMLATLDHGDTILVPNPSYPIHIYGA 140 Query: 157 ELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAIT---SKTKAVIINTPHNPIGK 213 + G +V VP+ P + F + E+AI K + +I+ P NP + Sbjct: 141 VIAGAQVRSVPLVPGIDF-------------FNELERAIRESIPKPRMMILGFPSNPTAQ 187 Query: 214 VFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSF 273 + + + +++V+++ D Y + + P + + + KS+ Sbjct: 188 CVELDFFERVVALAKQYDVMVVHDLAYADIVYDGWKAPSIMQVPGAKDIAVEFFTLSKSY 247 Query: 274 AATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEY 333 GWRIG+++ N EL+S A+ + + + +PLQ A ++ + + ++Y Sbjct: 248 NMAGWRIGFMVG-NPELVSALARIKSYHDYGTFTPLQVAAIAALEGDQQC--VRDIARQY 304 Query: 334 INKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLI 393 + + E G P+ + +V KIPE Y + + L+ Sbjct: 305 QQRRDVLVKGLREAGWMVENPKASMYVWA-----KIPEPYAHLG-------SLEFAKKLL 352 Query: 394 NELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLL 440 + V P F ++ +RFA+ ++ L AV +K + Sbjct: 353 QDAKVSVSPGIGFGD-----YGDDHVRFALIENRDRLRQAVRGIKAM 394 >2Z61-A nrPDB Length = 370 Score = 308 bits (789), Expect = 3e-84, Method: Composition-based stats. Identities = 91/394 (23%), Positives = 168/394 (42%), Gaps = 48/394 (12%) Query: 46 ANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLY 105 A +++G+++I+L G ++ P+ + E K+L + Y+ +RG L + +LY Sbjct: 21 AQKLESEGKKVIHLEIGEPDFNTPKPIVDEGIKSLKEGKTH-YTDSRGILELREKISELY 79 Query: 106 SPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVY 165 Y ++ +N+ +T G++ G+ L +++ GDEV++ P + Y I G K V+ Sbjct: 80 KDKYKADIIPDNIIITGGSSLGLFFALSSIIDDGDEVLIQNPCYPCYKNFIRFLGAKPVF 139 Query: 166 VPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGN 225 E E+A++ KTKA+IIN+P NP+G+V RE + Sbjct: 140 CD------------------FTVESLEEALSDKTKAIIINSPSNPLGEVIDRE----IYE 177 Query: 226 ICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLS 285 ++ IISDE+Y L + E + T+ + K +A TGWRIG+V+S Sbjct: 178 FAYENIPYIISDEIYNGLVYEGKCYSAIEFD-ENLEKTILINGFSKLYAMTGWRIGYVIS 236 Query: 286 LNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFD 345 N E++ K + ++P+ Q A + + M +E+ + ++ Sbjct: 237 -NDEIIEAILKLQQNLFISAPTISQYAALKAFEKETERE-INSMIKEFDRRRRLVLKYVK 294 Query: 346 ELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTE 405 + G P G Y+V + + ++ L+ E V P Sbjct: 295 DFGWEVNNPIGAYYVFPNIGE-----------------DGREFAYKLLKEKFVALTPGIG 337 Query: 406 FYIKEHEKAAENLLRFAVCKDDAYLENAVERLKL 439 F K +N +R + ++ +ER+K Sbjct: 338 FGSK-----GKNYIRISYANSYENIKEGLERIKE 366 >1V2E-A nrPDB Length = 381 Score = 300 bits (767), Expect = 1e-81, Method: Composition-based stats. Identities = 128/385 (33%), Positives = 200/385 (51%), Gaps = 44/385 (11%) Query: 56 LINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKA 115 +NLGQGF S PP F ++ ++AL +QY+P G P+L +L + ++ ++ Sbjct: 27 AVNLGQGFPSNPPPPFLLEAVRRAL--GRQDQYAPPAGLPALREALAEEFA------VEP 78 Query: 116 ENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELD 175 E+V VT+GA E + L L+ GDEV+V EPFFD Y+P+ L G K V ++ Sbjct: 79 ESVVVTSGATEALYVLLQSLVGPGDEVVVLEPFFDVYLPDAFLAGAKARLVRLDLTP--- 135 Query: 176 QRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVII 235 E + +D EKA+T +T+A+++NTP NP G VF EL + + H++ +I Sbjct: 136 ------EGFRLDLSALEKALTPRTRALLLNTPMNPTGLVFGERELEAIARLARAHDLFLI 189 Query: 236 SDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAA 295 SDEVY+ LY+ + R+ +PE T TVGSAGK ATG+R+GW++ E + A Sbjct: 190 SDEVYDELYYGERPRRLREFAPE---RTFTVGSAGKRLEATGYRVGWIVGP-KEFMPRLA 245 Query: 296 KAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPE 355 F++P+PLQ A ++ A + G++E +R+ Y + + +GL PE Sbjct: 246 GMRQWTSFSAPTPLQAGVAEALKLARREGFYEALREGYRRRRDLLAGGLRAMGLRVYVPE 305 Query: 356 GTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAA 415 GTYF++ + + L+ E V IP + FY+++ K Sbjct: 306 GTYFLMAELPGWD--------------------AFRLVEEARVALIPASAFYLEDPPK-- 343 Query: 416 ENLLRFAVCKDDAYLENAVERLKLL 440 +L RFA CK + L A+ERL + Sbjct: 344 -DLFRFAFCKTEEELHLALERLGRV 367 >1XI9-A nrPDB Length = 406 Score = 294 bits (753), Expect = 4e-80, Method: Composition-based stats. Identities = 84/415 (20%), Positives = 167/415 (40%), Gaps = 42/415 (10%) Query: 39 NEAAAKAANNSKNQGRELINLGQGFF---SYSPPQFAIKEAQKALDIPMVNQYSPTRGRP 95 A + +G ++I L G + PP+ + KA+ N Y + G P Sbjct: 23 IRDVVLPARELEKKGIKVIRLNIGDPVKFDFQPPEHMKEAYCKAIKEGH-NYYGDSEGLP 81 Query: 96 SLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPN 155 L ++++ ++ ++V VT E + LL+ GDE++V P + Y Sbjct: 82 ELRKAIVEREKRKNGVDITPDDVRVTAAVTEALQLIFGALLDPGDEILVPGPSYPPYTGL 141 Query: 156 IELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVF 215 ++ GGK V R E+W D + K IT +TKA+ + P+NP G ++ Sbjct: 142 VKFYGGKPVEY----------RTIEEEDWQPDIDDIRKKITDRTKAIAVINPNNPTGALY 191 Query: 216 TREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAA 275 ++ L + NI ++ + +ISDE+Y+ + + +L+ ++ + + K + A Sbjct: 192 DKKTLEEILNIAGEYEIPVISDEIYDLMTYEGEHISPGSLTKDVP--VIVMNGLSKVYFA 249 Query: 276 TGWRIGWVLSLNAE----LLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQ 331 TGWR+G++ ++ E + A RI +P Q A + + Y ++ + Sbjct: 250 TGWRLGYMYFVDPENKLSEVREAIDRLARIRLCPNTPAQFAAIAGLTGPMD--YLKEYMK 307 Query: 332 EYINKFKIFTSIFDE-LGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISH 390 + + +E G+ T P+G +++ E+ D Sbjct: 308 KLKERRDYIYKRLNEIPGISTTKPQGAFYIFPKI-------------EVGPWKNDKEFVL 354 Query: 391 WLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKL-LKDYL 444 +++ V+ + + F + R LE A++R + +K+ L Sbjct: 355 DVLHNAHVLFVHGSGFG-----EYGAGHFRAVFLPPIEILEEAMDRFEKFMKERL 404 >4MY5-A nrPDB Length = 393 Score = 291 bits (744), Expect = 5e-79, Method: Composition-based stats. Identities = 94/393 (23%), Positives = 169/393 (43%), Gaps = 41/393 (10%) Query: 55 ELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELK 114 +++ L G ++ P+ + A++A+D + Y+ G +L + Y+ Sbjct: 33 DVLKLTLGEPDFATPKHIKEAAKRAIDADESH-YTGMAGLLALRQAASAFVKEKYHLTYN 91 Query: 115 AEN-VTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKE 173 +N + VT GA E + + L +L GD+V++ P + Y P + L G +VV + Sbjct: 92 PDNEILVTIGATEALSASLTAILEPGDKVLLPAPAYPGYEPVVNLVGAEVVEI------- 144 Query: 174 LDQRNTRGEEWTIDFEQFEKAI---TSKTKAVIINTPHNPIGKVFTREELTTLGNICVKH 230 +TR ++ + E E+AI KAVI+N P NP G ++R+++ L + K+ Sbjct: 145 ----DTRSNDFVLTPEMLEEAILKEGEALKAVILNYPTNPTGVTYSRQQIKNLAEVLKKY 200 Query: 231 NVVIISDEVYEHLYFTD-SFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAE 289 + +ISDEVY L +T S IA P+ T+ + KS A TGWR+G + + A Sbjct: 201 PIFVISDEVYAELTYTGESHVSIAEYLPD---QTILISGLSKSHAMTGWRLGLIFAP-AV 256 Query: 290 LLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGL 349 L + K+H + A+ + +Q A ++ + M++EYI + + + Sbjct: 257 LTAQLIKSHQYLVTAATTSVQFAAIEALTNGKDDAL--PMKEEYIKRRDYIIEKMEAMKF 314 Query: 350 PYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIK 409 P+G +++ + F+ E V IP F Sbjct: 315 KIIKPDGAFYIFAKIP-------------VAQGQDSFKFLQDFAKEKAVAFIPGVAFG-- 359 Query: 410 EHEKAAENLLRFAVCKDDAYLENAVERLKLLKD 442 K E LR + ++ A++RLK + Sbjct: 360 ---KYGEGYLRISYAASMETIKEAMKRLKEFME 389 >2O0R-A nrPDB Length = 411 Score = 288 bits (736), Expect = 4e-78, Method: Composition-based stats. Identities = 118/395 (29%), Positives = 183/395 (46%), Gaps = 33/395 (8%) Query: 56 LINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKA 115 +NLGQGF P ++ AQ A+ VNQY P G L ++ + + Sbjct: 27 AVNLGQGFPDEDGPPKMLQAAQDAI-AGGVNQYPPGPGSAPLRRAIAAQRRRHFGVDYDP 85 Query: 116 E-NVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKEL 174 E V VT GA E I + ++GL+ G EV++ EPF+D Y P + + G V VP+ P Sbjct: 86 ETEVLVTVGATEAIAAAVLGLVEPGSEVLLIEPFYDSYSPVVAMAGAHRVTVPLVPD--- 142 Query: 175 DQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVI 234 G + +D + +A+T +T+A+IIN+PHNP G V + EL + I V N+V+ Sbjct: 143 ------GRGFALDADALRRAVTPRTRALIINSPHNPTGAVLSATELAAIAEIAVAANLVV 196 Query: 235 ISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYA 294 I+DEVYEHL F + + + T+T+ SA K F TGW+IGW AEL++ Sbjct: 197 ITDEVYEHLVFDHARHLPLAGFDGMAERTITISSAAKMFNCTGWKIGWACGP-AELIAGV 255 Query: 295 AKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAP 354 A + + +P Q A A +++ + + +R + + E+G Sbjct: 256 RAAKQYLSYVGGAPFQPAVALALDT--EDAWVAALRNSLRARRDRLAAGLTEIGFAVHDS 313 Query: 355 EGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKA 414 GTYF+ D + L ++GV AIP + F +A Sbjct: 314 YGTYFLCADPRPLG-------------YDDSTEFCAALPEKVGVAAIPMSAFCDPAAGQA 360 Query: 415 A------ENLLRFAVCKDDAYLENAVERLKLLKDY 443 + +L+RF CK D L+ A+ RL +L + Sbjct: 361 SQQADVWNHLVRFTFCKRDDTLDEAIRRLSVLAER 395 >5YHV-A nrPDB Length = 394 Score = 275 bits (703), Expect = 3e-74, Method: Composition-based stats. Identities = 90/404 (22%), Positives = 150/404 (37%), Gaps = 36/404 (8%) Query: 38 TNEAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSL 97 + AA + G +L+NL G S P+ A AL + + YS G P L Sbjct: 22 VMDVWLAAAERQRTHG-DLVNLSAGQPSAGAPEPVRAAAAAALHLNQL-GYSVALGIPEL 79 Query: 98 INSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIE 157 +++ Y + ++ + V +TTG++ G L + +AGD V + P + Y + Sbjct: 80 RDAIAADYQRRHGITVEPDAVVITTGSSGGFLLAFLACFDAGDRVAMASPGYPCYRNILS 139 Query: 158 LCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTR 217 G +VV +P P Q I + V++ +P NP G V Sbjct: 140 ALGCEVVEIPCGPQTRFQPT-----------AQMLAEIDPPLRGVVVASPANPTGTVIPP 188 Query: 218 EELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATG 277 EEL + + C +V +ISDEVY L + + + + + + + V S K +A TG Sbjct: 189 EELAAIASWCDASDVRLISDEVYHGLVYQGAPQ--TSCAWQTSRNAVVVNSFSKYYAMTG 246 Query: 278 WRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKF 337 WR+GW+L +L A T P L + A S + Y Sbjct: 247 WRLGWLLVP--TVLRRAVDCLTGNFTICPPVLSQIAAVSAFTPEATAEADGNLASYAINR 304 Query: 338 KIFTSIFDELGLPYTAP-EGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINEL 396 + +G+ AP +G ++V D S L+ + Sbjct: 305 SLLLDGLRRIGIDRLAPTDGAFYVYADVSDFT--------------SDSLAFCSKLLADT 350 Query: 397 GVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLL 440 GV P +F + +R + +E A+ R+ Sbjct: 351 GVAIAPGIDFDTAR----GGSFVRISFAGPSGDIEEALRRIGSW 390 >3H14-A nrPDB Length = 391 Score = 273 bits (697), Expect = 1e-73, Method: Composition-based stats. Identities = 80/400 (20%), Positives = 147/400 (36%), Gaps = 41/400 (10%) Query: 41 AAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINS 100 +AA ++ GR +I++ G P+ A++ K+L+ + Y+ G P+L Sbjct: 18 DVMEAARRAEEAGRRIIHMEVGQPGTGAPRGAVEALAKSLETDAL-GYTVALGLPALRQR 76 Query: 101 LIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCG 160 + +LY Y +L V +T G++ G L L ++GD V + P + Y + G Sbjct: 77 IARLYGEWYGVDLDPGRVVITPGSSGGFLLAFTALFDSGDRVGIGAPGYPSYRQILRALG 136 Query: 161 GKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREEL 220 V +P P L DF + A +++ +P NP G + + Sbjct: 137 LVPVDLPTAPENRLQPV-------PADFAGLDLA------GLMVASPANPTGTMLDHAAM 183 Query: 221 TTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRI 280 L ISDE+Y + + L+ E + S K F+ TGWR+ Sbjct: 184 GALIEAAQAQGASFISDEIYHGIEYEAKAVTALELTDE----CYVINSFSKYFSMTGWRV 239 Query: 281 GWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIF 340 GW++ ++ A + +P Q ++ + Y K+ Sbjct: 240 GWMVVPEDQVRVVERIAQ-NMFICAPHASQ---VAALAALDCDAELQANLDVYKANRKLM 295 Query: 341 TSIFDELGL-PYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVV 399 + G P+G ++V D S + + ++ + GV Sbjct: 296 LERLPKAGFTRIAPPDGAFYVYADVSDLT--------------DDSRAFAAEILEKAGVA 341 Query: 400 AIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKL 439 P +F + LRF+ + A +E ++RL+ Sbjct: 342 VTPGLDF----DPERGAGTLRFSYARATADIEEGLDRLEA 377 >2O1B-A nrPDB Length = 404 Score = 270 bits (690), Expect = 8e-73, Method: Composition-based stats. Identities = 82/396 (20%), Positives = 153/396 (38%), Gaps = 36/396 (9%) Query: 47 NNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYS 106 ++ LIN+ G PQ I QKAL IP +Y G+ + +++ Y Sbjct: 40 RKIEHGPLPLINMAVGIPDGPTPQGIIDHFQKALTIPENQKYGAFHGKEAFKQAIVDFYQ 99 Query: 107 PIYNTELKAEN-VTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVY 165 YN L E+ V + G G+++ ++N GD V++ +P + Y+ + L GK V Sbjct: 100 RQYNVTLDKEDEVCILYGTKNGLVAVPTCVINPGDYVLLPDPGYTDYLAGVLLADGKPVP 159 Query: 166 VPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGN 225 + + PP + D+ + + I KTK + + P+NP G T+E Sbjct: 160 LNLEPP-----------HYLPDWSKVDSQIIDKTKLIYLTYPNNPTGSTATKEVFDEAIA 208 Query: 226 ICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLS 285 + I+ D Y F I S + + + S K + +G+R+G+ + Sbjct: 209 KFKGTDTKIVHDFAYGAFGFDAKNPSILA-SENGKDVAIEIYSLSKGYNMSGFRVGFAVG 267 Query: 286 LNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFD 345 N +++ K T LQ+A ++N + E+ + + F ++ Sbjct: 268 -NKDMIQALKKYQTHTNAGMFGALQDAAIYALNHYDD--FLEEQSNVFKTRRDRFEAMLA 324 Query: 346 ELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTE 405 + LP+ +G +V ++ + +L+ E ++ P Sbjct: 325 KADLPFVHAKGGIYVWLETP---------------PGYDSEQFEQFLVQEKSILVAPGKP 369 Query: 406 FYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLK 441 F + +R ++ DD L+ A RL L Sbjct: 370 FG-----ENGNRYVRISLALDDQKLDEAAIRLTELA 400 >3PDX-A nrPDB Length = 402 Score = 264 bits (675), Expect = 5e-71, Method: Composition-based stats. Identities = 98/438 (22%), Positives = 169/438 (38%), Gaps = 54/438 (12%) Query: 17 RPKVVANKYFTSNTAKDVWSLTNEAAAKAANNSKNQGRELINLGQGFF----SYSPPQFA 72 RP ++NK F + ++ + K N + +I+L G + Sbjct: 4 RPSDMSNKTFNP-----IRAIVDNMKVKP-----NPNKTVISLSIGDPTVFGNLPTDPEV 53 Query: 73 IKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCL 132 + + ALD N Y+P+ G S + Y L+A++V +T+G ++ I CL Sbjct: 54 TQAMKDALDSGKYNGYAPSIGYLSSREEVASYYH-CPEAPLEAKDVILTSGCSQAIELCL 112 Query: 133 MGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFE 192 L N G +++ P F Y E G +V + P K W ID +Q E Sbjct: 113 AVLANPGQNILIPRPGFSLYRTLAESMGIEVKLYNLLPEKS----------WEIDLKQLE 162 Query: 193 KAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTD-SFTR 251 I KT +++N P NP G VF++ L + + + V I++DE+Y + F+D + Sbjct: 163 SLIDEKTACLVVNNPSNPCGSVFSKRHLQKILAVAERQCVPILADEIYGDMVFSDCKYEP 222 Query: 252 IATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNA------ELLSYAAKAHTRICFAS 305 +ATLS + L+ G K + GWR+GW+L + E+ K RI Sbjct: 223 MATLSTNVP--ILSCGGLAKRWLVPGWRLGWILIHDRRDIFGNEIRDGLVKLSQRI-LGP 279 Query: 306 PSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIF-DELGLPYTAPEGTYFVLVDF 364 + +Q A + + + +++ + + GL P G +++V Sbjct: 280 CTIVQGALKSILQRTPQ-EFYQDTLSFLKSNADLCYGALSAIPGLQPVRPSGAMYLMVGI 338 Query: 365 SKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVC 424 E D + LI E V +P T F N R + Sbjct: 339 ----------EMEHFPEFENDVEFTERLIAEQSVHCLPATCFEYP-------NFFRVVIT 381 Query: 425 KDDAYLENAVERLKLLKD 442 + + A R++ + Sbjct: 382 VPEVMMLEACSRIQEFCE 399 >2GB3-A nrPDB Length = 409 Score = 262 bits (668), Expect = 3e-70, Method: Composition-based stats. Identities = 94/398 (23%), Positives = 165/398 (41%), Gaps = 43/398 (10%) Query: 46 ANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLY 105 A +K +G + +L G P+ + + + P V YS + G L + Y Sbjct: 35 AEMAKKRGVRIHHLNIGQPDLKTPEVFFERIYE--NKPEVVYYSHSAGIWELREAFASYY 92 Query: 106 SPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVY 165 ++K ENV VT G +E IL + N GDE++V EPF+ Y ++ G K++ Sbjct: 93 KRRQRVDVKPENVLVTNGGSEAILFSFAVIANPGDEILVLEPFYANYNAFAKIAGVKLIP 152 Query: 166 VPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGN 225 V R EE + E I +TK ++++ P NP G V+ ++E+ L Sbjct: 153 V-----------TRRMEEGFAIPQNLESFINERTKGIVLSNPCNPTGVVYGKDEMRYLVE 201 Query: 226 ICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLS 285 I +H + +I DEVY + F F ++ + + S K F+A G R+G +++ Sbjct: 202 IAERHGLFLIVDEVYSEIVFRGEFASALSIE---SDKVVVIDSVSKKFSACGARVGCLIT 258 Query: 286 LNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFD 345 N EL+S+A K PL E + L +F+ +R+ Y + + + Sbjct: 259 RNEELISHAMKLAQG---RLAPPLLEQIGSVGLLNLDDSFFDFVRETYRERVETVLKKLE 315 Query: 346 ELGLP-YTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGV-----V 399 E GL +T P G +++ + L + W++ + + + Sbjct: 316 EHGLKRFTKPSGAFYITAE----------------LPVEDAEEFARWMLTDFNMDGETTM 359 Query: 400 AIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERL 437 P FY+ + +R A + L A++ L Sbjct: 360 VAPLRGFYLTPG--LGKKEIRIACVLEKDLLSRAIDVL 395 >3DYD-A nrPDB Length = 427 Score = 260 bits (664), Expect = 1e-69, Method: Composition-based stats. Identities = 100/442 (22%), Positives = 170/442 (38%), Gaps = 54/442 (12%) Query: 13 MSTSRPKVVANKYFTSNTAKDVWSLTNEAAAKAANNSKNQGRELINLGQGFF----SYSP 68 M + RP +A K F + ++ + K N + +I+L G + Sbjct: 23 MWSVRPSDMAKKTFNP-----IRAIVDNMKVKP-----NPNKTMISLSIGDPTVFGNLPT 72 Query: 69 PQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGI 128 + + ALD N Y+P+ G S + Y L+A++V +T+G ++ I Sbjct: 73 DPEVTQAMKDALDSGKYNGYAPSIGFLSSREEIASYYH-CPEAPLEAKDVILTSGCSQAI 131 Query: 129 LSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDF 188 CL L N G ++V P F Y E G +V + P K W ID Sbjct: 132 DLCLAVLANPGQNILVPRPGFSLYKTLAESMGIEVKLYNLLPEKS----------WEIDL 181 Query: 189 EQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTD- 247 +Q E I KT +I+N P NP G VF++ L + + + V I++DE+Y + F+D Sbjct: 182 KQLEYLIDEKTACLIVNNPSNPCGSVFSKRHLQKILAVAARQCVPILADEIYGDMVFSDC 241 Query: 248 SFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNA------ELLSYAAKAHTRI 301 + +ATLS ++ L+ G K + GWR+GW+L + E+ K RI Sbjct: 242 KYEPLATLSTDVP--ILSCGGLAKRWLVPGWRLGWILIHDRRDIFGNEIRDGLVKLSQRI 299 Query: 302 CFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDE-LGLPYTAPEGTYFV 360 + +Q A + + ++ + + GL P G ++ Sbjct: 300 -LGPCTIVQGALKSILCRTPG-EFYHNTLSFLKSNADLCYGALAAIPGLRPVRPSGAMYL 357 Query: 361 LVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLR 420 +V E D + L+ E V +P T F N +R Sbjct: 358 MVGI----------EMEHFPEFENDVEFTERLVAEQSVHCLPATCFEYP-------NFIR 400 Query: 421 FAVCKDDAYLENAVERLKLLKD 442 + + + A R++ + Sbjct: 401 VVITVPEVMMLEACSRIQEFCE 422 >4CVQ-A nrPDB Length = 431 Score = 256 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 88/438 (20%), Positives = 177/438 (40%), Gaps = 55/438 (12%) Query: 23 NKYFT--------SNTAKDVWSLTNEAAAKAANNSKNQGRELINLGQGFF---SYSPPQF 71 N YF S+ ++V K A + +G +++ L G + P Sbjct: 20 NLYFEGAMSPIEKSSKLENVCYDIRGPVLKEAKRLEEEGNKVLKLNIGNPAPFGFDAPDE 79 Query: 72 AIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSC 131 + + + ++P Y ++G S ++++ Y ++ E++ + G +E I+ Sbjct: 80 ILVDVIR--NLPTAQGYCDSKGLYSARKAIMQHYQARGMRDVTVEDIYIGNGVSELIVQA 137 Query: 132 LMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQF 191 + LLN+GDE++V P + + + L GK V+ + +W D + Sbjct: 138 MQALLNSGDEMLVPAPDYPLWTAAVSLSSGKAVHYLCD----------ESSDWFPDLDDI 187 Query: 192 EKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTD-SFT 250 IT +T+ ++I P+NP G V+++E L + I +HN++I +DE+Y+ + + D Sbjct: 188 RAKITPRTRGIVIINPNNPTGAVYSKELLMEIVEIARQHNLIIFADEIYDKILYDDAEHH 247 Query: 251 RIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVL--SLNAE----LLSYAAKAHTRICFA 304 IA L+P++ LT+T K++ G+R GW++ + A R+C Sbjct: 248 SIAPLAPDL--LTITFNGLSKTYRVAGFRQGWMVLNGPKKHAKGYIEGLEMLASMRLCAN 305 Query: 305 SPSPLQEACANSINDALKI-GYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVL-- 361 P+ Q A ++ I + + Y + + + I D G+ P G ++ Sbjct: 306 VPA--QHAIQTALGGYQSISEFITPGGRLYEQRNRAWELINDIPGVSCVKPRGALYMFPK 363 Query: 362 VDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRF 421 +D + I +D + L+ E V+ + T F + R Sbjct: 364 IDAKRFNIHDDQKMVLDF------------LLQEK-VLLVQGTAFNWPWP-----DHFRI 405 Query: 422 AVCKDDAYLENAVERLKL 439 +E ++ + Sbjct: 406 VTLPRVDDIELSLSKFAR 423 >4IX8-A nrPDB Length = 444 Score = 251 bits (641), Expect = 4e-67, Method: Composition-based stats. Identities = 89/402 (22%), Positives = 157/402 (39%), Gaps = 45/402 (11%) Query: 57 INLGQGFF----SYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTE 112 + L G + P + + N Y PT G +L + + T+ Sbjct: 70 LRLSIGDPTVDGNLKTPDIVTEAMVDVVRSGKFNGYPPTVGADNLRQVVSTYWRRFCQTK 129 Query: 113 -----LKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVP 167 LK ENV +T+G ++ I+ L L N GD ++V P F Y + G + Y Sbjct: 130 SRQEALKWENVIITSGVSQAIVLALTALCNEGDNILVCAPSFPHYKSVCDSYGIECRYYY 189 Query: 168 INPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNIC 227 ++P K W D + S TKA +I P NP G F+R ++ + + C Sbjct: 190 LDPSKS----------WECDLRAAAGMVDSHTKAFVIINPSNPCGSNFSRAHVSDIIDFC 239 Query: 228 VKHNVVIISDEVYEHLYFTDS-FTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSL 286 +H + +ISDE+Y + + FT +A + + L +G K GWR+GW + + Sbjct: 240 QQHQIPLISDEIYAEMVLNNGIFTSVADFDTNVPR--LILGGTAKYQVCPGWRVGWSILI 297 Query: 287 NA----ELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTS 342 + + + T++ S QEA A ++ E + + K++ Sbjct: 298 DPMNVAGDWAVGMERLTQLIAGVNSICQEAIARTLLKCPT-ECTEHIVTQLEAGAKVYAR 356 Query: 343 IFD-ELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAI 401 + + ++G+ AP+ + FV++ + + D L++E V + Sbjct: 357 LLEHDIGISMEAPQASMFVMLKLN----------LSYFQDLKSDMEFYEKLLDEENVQVL 406 Query: 402 PPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLKDY 443 P F LR V + A L AV+R+ + Sbjct: 407 PGEIF-------GMSGFLRATVSRPSAVLNEAVDRIIEFCER 441 >3JTX-A nrPDB Length = 396 Score = 250 bits (639), Expect = 7e-67, Method: Composition-based stats. Identities = 86/406 (21%), Positives = 152/406 (37%), Gaps = 50/406 (12%) Query: 49 SKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPI 108 S +G E + L G + P+ +L + +Y T G P L + Sbjct: 25 SAPEGMEAVPLHIGEPKHPTPKVITDALTASLH--ELEKYPLTAGLPELRQACANWLKRR 82 Query: 109 Y-NTELKAEN-VTVTTGANEGILSCLMGLLNAGDE-----VIVFEPFFDQYIPNIELCGG 161 Y + A+N + G+ E + S + +LN + ++ PF+ Y L GG Sbjct: 83 YDGLTVDADNEILPVLGSREALFSFVQTVLNPVSDGIKPAIVSPNPFYQIYEGATLLGGG 142 Query: 162 KVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELT 221 ++ + N + D+ + + +TK V + +P+NP G V + Sbjct: 143 EIHF-----------ANCPAPSFNPDWRSISEEVWKRTKLVFVCSPNNPSGSVLDLDGWK 191 Query: 222 TLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEI-----GQLTLTVGSAGKSFAAT 276 + ++ K+ +I SDE Y +YF D + L Q L S K Sbjct: 192 EVFDLQDKYGFIIASDECYSEIYF-DGNKPLGCLQAAAQLGRSRQKLLMFTSLSKRSNVP 250 Query: 277 GWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINK 336 G R G+V +AELL T A P+Q A + +D + R+ Y K Sbjct: 251 GLRSGFVAG-DAELLKNFLLYRTYHGSAMSIPVQRASIAAWDDE---QHVIDNRRLYQEK 306 Query: 337 FKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINEL 396 F+ I ++ P+ ++++ +K+P+ G D + L + Sbjct: 307 FERVIPILQQV-FDVKLPDASFYIW-----LKVPD-----------GDDLAFARNLWQKA 349 Query: 397 GVVAIPPTEFYIKEHEKA--AENLLRFAVCKDDAYLENAVERLKLL 440 + +P F ++ E+ E +R A+ D A A E + L Sbjct: 350 AIQVLPG-RFLARDTEQGNPGEGYVRIALVADVATCVKAAEDIVSL 394 >2ZC0-A nrPDB Length = 407 Score = 246 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 93/427 (21%), Positives = 154/427 (36%), Gaps = 44/427 (10%) Query: 26 FTSNTAKDVWSLTNEAAAKAANNSKNQGRELINLGQGFFSYSPPQFAI--KEAQKALDI- 82 + + A + K A+ + +G +LI+L G A+ + A++ L+ Sbjct: 6 YLAGRANWIKGSALADVMKKASELQKKGVKLISLAAGDPDPELIPRAVLGEIAKEVLEKE 65 Query: 83 PMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEV 142 P Y+P G P L L + E+ EN+ +T G + L++ GD V Sbjct: 66 PKSVMYTPANGIPELREELAAFLKKYDHLEVSPENIVITIGGTGALDLLGRVLIDPGDVV 125 Query: 143 IVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAV 202 I P + + E G K+ VP+ D R + ++ + Sbjct: 126 ITENPSYINTLLAFEQLGAKIEGVPV------DNDGMRVDLLEEKIKELKAKGQKVKLIY 179 Query: 203 IINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDS-FTRIATLSPEIGQ 261 I T NP+G + E L I K++++II D Y + + + L E Sbjct: 180 TIPTGQNPMGVTMSMERRKALLEIASKYDLLIIEDTAYNFMRYEGGDIVPLKALDNEG-- 237 Query: 262 LTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDAL 321 + G+ K TG+RIGW+++ E+L I F +P+ Q + L Sbjct: 238 RVIVAGTLSKVLG-TGFRIGWIIA-EGEILKKVLMQKQPIDFCAPAISQYIAL----EYL 291 Query: 322 KIGYFEKMRQE-----YINKFKIFTSIFDE--LGLPYTAPEGTYFVLVDFSKVKIPEDYP 374 K GYFEK E Y K I + +T P FV+ Sbjct: 292 KRGYFEKYHLEGALLGYKEKRDIMLKALENHLPNAEFTKPIAGMFVMFFLP--------- 342 Query: 375 YPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCK-DDAYLENA 433 ++ L+ GVV +P FY E K A +R + + Sbjct: 343 ------EGADGISFANELMEREGVVVVPGKPFYTDESGKNA---IRLNFSRPSKEEIPIG 393 Query: 434 VERLKLL 440 +++L L Sbjct: 394 IKKLAKL 400 >3AV7-A nrPDB Length = 448 Score = 235 bits (600), Expect = 3e-62, Method: Composition-based stats. Identities = 77/424 (18%), Positives = 150/424 (35%), Gaps = 50/424 (11%) Query: 37 LTNEAAAKAANNSKN--QGRELINLGQGFFSYSP-PQFAI---------KEAQKALDIPM 84 E A + ++I+L G + P+ I K A KAL Sbjct: 57 KALEMRASEVRELLKLVETSDIISLAGGLPNPKTFPKEIIRDILVEIMEKYADKAL---- 112 Query: 85 VNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIV 144 QY T+G L +L+K Y ++ +T+G+ + + LN GD V+V Sbjct: 113 --QYGTTKGFTPLRETLMKWLGKRYGISQD-NDIMITSGSQQALDLIGRVFLNPGDIVVV 169 Query: 145 FEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVII 204 P + + + + +P LD + E ++ + + Sbjct: 170 EAPTYLAALQAFNFYEPQYIQIP------LDDEGMKVEILEEKLKELKSQGKKVKVVYTV 223 Query: 205 NTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTL 264 T NP G + L + +++ +++ D+ Y L ++ + + + + + Sbjct: 224 PTFQNPAGVTMNEDRRKYLLELASEYDFIVVEDDPYGELRYSGNPEKKIK-ALDNEGRVI 282 Query: 265 TVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIG 324 +G+ K A G+RIGW++ + ++ A + Q ++ Sbjct: 283 YLGTFSKILA-PGFRIGWMVG-DPGIIRKMEIAKQSTDLCTNVFGQVVAWRYVDGGYLEK 340 Query: 325 YFEKMRQEYINKFKIFTSIFDEL---GLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILN 381 + ++R+ Y + +E G+ +T PEG F+ V L Sbjct: 341 HIPEIRKFYKPRRDAMLEALEEFMPEGVKWTKPEGGMFIWV----------------TLP 384 Query: 382 KGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERL-KLL 440 G D + + GV +P FY K L F D+ + ++RL + + Sbjct: 385 DGIDSKKMLERAIKKGVAYVPGEAFYAHRDVKNTMR-LNFTYV-DEDKIMEGIKRLAETI 442 Query: 441 KDYL 444 K+ L Sbjct: 443 KEEL 446 >1WST-A nrPDB Length = 417 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 75/392 (19%), Positives = 141/392 (35%), Gaps = 34/392 (8%) Query: 55 ELINLGQGFFSYS--PPQFAIKEAQKALDI--PMVNQYSPTRGRPSLINSLIKLYSPIYN 110 ++I+L G + P + K A + L+ QY T+G L +L + Y+ Sbjct: 42 DVISLAGGLPAPETFPVETIKKIAVEVLEEHADKALQYGTTKGFTPLRLALARWMEKRYD 101 Query: 111 TELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINP 170 + + G+ + + LN GD ++V P + I + + + +P Sbjct: 102 IPMSKVEIMTVAGSQQALDLIGRVFLNPGDPIVVEAPTYLAAIQAFKYYDPEFISIP--- 158 Query: 171 PKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKH 230 LD + R + E+ K ++T NP G + + L + ++ Sbjct: 159 ---LDDKGMRVDLLEEKLEELRKQGKRVKIVYTVSTFQNPAGVTMSVDRRKKLLELANEY 215 Query: 231 NVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAEL 290 + +I+ D Y L ++ T + G + +G+ K A G+RIGWV + + L Sbjct: 216 DFLIVEDGPYSELRYSGEPTPPIKHFDDYG-RVIYLGTFSKILA-PGFRIGWVAA-HPHL 272 Query: 291 LSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDEL--- 347 + A I + + Q + + + K+ + Y + +E Sbjct: 273 IRKMEIAKQSIDLCTNTFGQAIAWKYVENGYLDEHIPKIIEFYKPRRDAMLEALEEYMPE 332 Query: 348 GLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFY 407 G+ +T PEG FV L +G D ++ GV +P F+ Sbjct: 333 GVEWTKPEGGMFV----------------RVTLPEGIDTKLMMERAVAKGVAYVPGEAFF 376 Query: 408 IKEHEKAAENLLRFAVCKDDAYLENAVERLKL 439 + +K L F + + V RL Sbjct: 377 VHRDKKNTMR-LNFTYV-PEETIREGVRRLAE 406 >1X0M-A nrPDB Length = 403 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 77/424 (18%), Positives = 150/424 (35%), Gaps = 50/424 (11%) Query: 37 LTNEAAAKAANNSKN--QGRELINLGQGFFSYSP-PQFAI---------KEAQKALDIPM 84 E A + ++I+L G + P+ I K A KAL Sbjct: 12 KALEMRASEVRELLKLVETSDIISLAGGLPNPKTFPKEIIRDILVEIMEKYADKAL---- 67 Query: 85 VNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIV 144 QY T+G L +L+K Y ++ +T+G+ + + LN GD V+V Sbjct: 68 --QYGTTKGFTPLRETLMKWLGKRYGISQD-NDIMITSGSQQALDLIGRVFLNPGDIVVV 124 Query: 145 FEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVII 204 P + + + + +P LD + E ++ + + Sbjct: 125 EAPTYLAALQAFNFYEPQYIQIP------LDDEGMKVEILEEKLKELKSQGKKVKVVYTV 178 Query: 205 NTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTL 264 T NP G + L + +++ +++ D+ Y L ++ + + + + + Sbjct: 179 PTFQNPAGVTMNEDRRKYLLELASEYDFIVVEDDPYGELRYSGNPEKKIK-ALDNEGRVI 237 Query: 265 TVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIG 324 +G+ K A G+RIGW++ + ++ A + Q ++ Sbjct: 238 YLGTFSKILA-PGFRIGWMVG-DPGIIRKMEIAKQSTDLCTNVFGQVVAWRYVDGGYLEK 295 Query: 325 YFEKMRQEYINKFKIFTSIFDEL---GLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILN 381 + ++R+ Y + +E G+ +T PEG F+ V L Sbjct: 296 HIPEIRKFYKPRRDAMLEALEEFMPEGVKWTKPEGGMFIWV----------------TLP 339 Query: 382 KGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERL-KLL 440 G D + + GV +P FY K L F D+ + ++RL + + Sbjct: 340 DGIDSKKMLERAIKKGVAYVPGEAFYAHRDVKNTMR-LNFTYV-DEDKIMEGIKRLAETI 397 Query: 441 KDYL 444 K+ L Sbjct: 398 KEEL 401 >4DQ6-A nrPDB Length = 391 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 84/405 (20%), Positives = 161/405 (39%), Gaps = 36/405 (8%) Query: 38 TNEAAAKAANNSKNQG-RELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPS 96 +N ++K + K G +L+ + + I + L+ + + S Sbjct: 15 SNNFSSKWSEMEKKYGTNDLLPMWVADMDFKAAPCIIDSLKNRLEQEIYGYTTRPD---S 71 Query: 97 LINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNI 156 S++ +N ++K+E + + G I + L A D++++ EP + + + Sbjct: 72 YNESIVNWLYRRHNWKIKSEWLIYSPGVIPAISLLINELTKANDKIMIQEPVYSPFNSVV 131 Query: 157 ELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFT 216 + +++ P+ + +D+E E I K I+ PHNP+G+V+T Sbjct: 132 KNNNRELIISPLQK--------LENGNYIMDYEDIENKIKD-VKLFILCNPHNPVGRVWT 182 Query: 217 REELTTLGNICVKHNVVIISDEVYEHLYF-TDSFTRIATLSPEIGQLTLTVGSAGKSFAA 275 ++EL LG+IC+KHNV IISDE++ + +A++S E + T+T + K+F Sbjct: 183 KDELKKLGDICLKHNVKIISDEIHSDIILKKHKHIPMASISKEFEKNTITCMAPTKTFNI 242 Query: 276 TGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYIN 335 G + +V+ + + A TRI + + + + + E + + Sbjct: 243 AGLQSSYVVLPDEKDYKLLDDAFTRIDIKRNNCFSLVATEASYNNGE-SWLESFLEYLES 301 Query: 336 KFKIFTSIFDE--LGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLI 393 +E L PEGTY + VDFS + + D + L+ Sbjct: 302 NIDFAIKYINENMPKLKVRKPEGTYLLWVDFSALGL--------------SDEELESILV 347 Query: 394 NELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLK 438 + V F I R + + LE A+ R+K Sbjct: 348 QKGKVALNQGNSFGI-----GGSGYQRINLACPRSMLEEALIRIK 387 >3T32-A nrPDB Length = 383 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 76/391 (19%), Positives = 155/391 (39%), Gaps = 37/391 (9%) Query: 52 QGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNT 111 + ELI+ + PQ +K ++ P+ P + + YN Sbjct: 22 KNEELIHAWIADMDFEVPQPIQTALKKRIEHPIFGYTLPPENIGDI---ICNWTKKQYNW 78 Query: 112 ELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPP 171 +++ E + + G + + + + V+V P + + + ++ P+ Sbjct: 79 DIQKEWIVFSAGIVPALSTSIQAFTKENESVLVQPPIYPPFFEMVTTNNRQLCVSPLQKQ 138 Query: 172 KELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHN 231 + + IDFE EK K +++ +PHNPIG+V+ +EELT LG++C K+N Sbjct: 139 N---------DTYAIDFEHLEKQFQQGVKLMLLCSPHNPIGRVWKKEELTKLGSLCTKYN 189 Query: 232 VVIISDEVYEHLYFTD-SFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAEL 290 V++++DE++ + + D + T A+LS E+ T+T + K+F G + ++ N +L Sbjct: 190 VIVVADEIHSDIIYADHTHTPFASLSEELAARTITCMAPSKTFNIAGLQASIIIIPNEKL 249 Query: 291 LSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDE--LG 348 R F + S + ++R + K + Sbjct: 250 RQAFTSIQYRQGFHGLNIFAYTAMQSAYTECN-DWLNEIRFYIEDNAKFACEYIKDHIPT 308 Query: 349 LPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELG-VVAIPPTEFY 407 L PEG++ + +D S + + +D L+ E G ++ P ++ Sbjct: 309 LSVMKPEGSFLLWIDCSALNLSQDERT---------------KLLEEKGKIIVEPGEKYG 353 Query: 408 IKEHEKAAENLLRFAVCKDDAYLENAVERLK 438 + E + + + LE + RL+ Sbjct: 354 L-----GGEEHIGINIGCPRSVLEEILNRLR 379 >2DOU-A nrPDB Length = 376 Score = 232 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 67/400 (16%), Positives = 133/400 (33%), Gaps = 39/400 (9%) Query: 44 KAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIK 103 +A ++ +G LI+L G PP+ +K +AL+ P Y + + Sbjct: 15 EAKRKARERGVGLIDLSIGSTDLPPPEAPLKALAEALNDPTTYGYCLKSCTLPFLEEAAR 74 Query: 104 LYSPIYNTELKA-ENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGK 162 Y Y L G+ EG+ L+ L D +++ E + Y + + Sbjct: 75 WYEGRYGVGLDPRREALALIGSQEGLAHLLLALTEPEDLLLLPEVAYPSYFGAARVASLR 134 Query: 163 VVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTT 222 +P+ E+ D + + + + K +++N P+NP G V Sbjct: 135 TFLIPLR------------EDGLADLKAVPEGVWREAKVLLLNYPNNPTGAVADWGYFEE 182 Query: 223 LGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGW 282 + KH + +I D Y + L P + + + S KS+ G+R+G+ Sbjct: 183 ALGLARKHGLWLIHDNPYVDQVYEGEAPSPLAL-PGAKERVVELFSLSKSYNLAGFRLGF 241 Query: 283 VLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTS 342 L + E L+ + I F + + ++ ++ + Y + Sbjct: 242 ALG-SEEALARLERVKGVIDFNQYAGVLRMGVEALKTPKEV--VRGYARVYRERALGMAE 298 Query: 343 IFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIP 402 + L P T ++ + D L+ E GV Sbjct: 299 ALKGV-LSLLPPRATMYLW---------------GRLPEGVDDLEFGLRLV-ERGVALA- 340 Query: 403 PTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLKD 442 + + +R A+ + L A +R++ D Sbjct: 341 ----PGRGFGPGGKGFVRIALVRPLEELLEAAKRIREALD 376 >1BW0-A nrPDB Length = 416 Score = 231 bits (588), Expect = 6e-61, Method: Composition-based stats. Identities = 82/412 (19%), Positives = 158/412 (38%), Gaps = 54/412 (13%) Query: 54 RELINLGQGFFSYS----PPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLY---- 105 + +I L G + IK+ ++A+D N Y PT G P ++ + Sbjct: 33 KPIIKLSVGDPTLDKNLLTSAAQIKKLKEAIDSQECNGYFPTVGSPEAREAVATWWRNSF 92 Query: 106 --SPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKV 163 + + +NV + +G + GIL + + +AGD +V +P F Y + G + Sbjct: 93 VHKEELKSTIVKDNVVLCSGGSHGILMAITAICDAGDYALVPQPGFPHYETVCKAYGIGM 152 Query: 164 VYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTL 223 + P +W D ++ + KTK +I+ P NP G F+R+ + + Sbjct: 153 HFYNCRPEN----------DWEADLDEIRRLKDDKTKLLIVTNPSNPCGSNFSRKHVEDI 202 Query: 224 GNICVKHNVVIISDEVYEHLYFTDS-----FTRIATLSPEIGQLTLTVGSAGKSFAATGW 278 + + + + SDE+Y + F FT +A + + + +G K+ GW Sbjct: 203 VRLAEELRLPLFSDEIYAGMVFKGKDPNATFTSVADFETTVPR--VILGGTAKNLVVPGW 260 Query: 279 RIGWVLSLNAE-----LLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEY 333 R+GW+L ++ L + +C + +Q A ++ + + + + + Sbjct: 261 RLGWLLYVDPHGNGPSFLEGLKRVGMLVC-GPCTVVQAALGEALLNTPQEHLDQIVAKIE 319 Query: 334 INKFKIFTSIFDELGLPYTAPEGTYFVL--VDFSKVKIPEDYPYPEEILNKGKDFRISHW 391 + ++ I + +GL T P G +++ +D K + + D Sbjct: 320 ESAMYLYNHIGECIGLAPTMPRGAMYLMSRIDLEKYR------------DIKTDVEFFEK 367 Query: 392 LINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLKDY 443 L+ E V +P T F A R + AVER+K Sbjct: 368 LLEEENVQVLPGTIF-------HAPGFTRLTTTRPVEVYREAVERIKAFCQR 412 >3ELE-A nrPDB Length = 398 Score = 228 bits (580), Expect = 4e-60, Method: Composition-based stats. Identities = 89/424 (20%), Positives = 157/424 (37%), Gaps = 62/424 (14%) Query: 34 VWSLTNEAAAKAANNSKNQGRE-LINLGQGFFSYSPPQFA---IKEAQKALDIPMVNQYS 89 V S E + G+E + + G S PQ IKE D ++ Y+ Sbjct: 14 VRSAIRELFEYGKKRAAIVGKENVYDFSIGNPSIPAPQIVNDTIKELVTDYDSVALHGYT 73 Query: 90 PTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLL-NAGDEVIVFEPF 148 +G ++ + + + T A+N+ +T GA + C L +A DE I P+ Sbjct: 74 SAQGDVETRAAIAEFLNNTHGTHFNADNLYMTMGAAASLSICFRALTSDAYDEFITIAPY 133 Query: 149 FDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPH 208 F +Y + G ++V VP + E + IDF+ E+ I + T+ VIIN+P+ Sbjct: 134 FPEYKVFVNAAGARLVEVPADT-----------EHFQIDFDALEERINAHTRGVIINSPN 182 Query: 209 NPIGKVFTREELTTLGNICVKHN------VVIISDEVYEHLYFTDSFTRIATLSPEIGQL 262 NP G V++ E + L ++ K + + II+DE Y + + T + Sbjct: 183 NPSGTVYSEETIKKLSDLLEKKSKEIGRPIFIIADEPYREIVYDGIKVPFVT---KYYDN 239 Query: 263 TLTVGSAGKSFAATGWRIGWVLSLN-----AELLSYAAKAHTRICF-ASPSPLQEACANS 316 TL S KS + G RIG+VL + AEL + A + + +PS Q+ Sbjct: 240 TLVCYSYSKSLSLPGERIGYVLVPDEVYDKAELYAAVCGAGRALGYVCAPSLFQKMIVKC 299 Query: 317 INDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYP 376 I Y + +G P+G +++ V Sbjct: 300 QGATGDINA-------YKENRDLLYEGLTRIGYHCFKPDGAFYMFVK------------- 339 Query: 377 EEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVER 436 + E V+ + F +R + C D +++++ Sbjct: 340 ---ALEDDSNAFCEK-AKEEDVLIVAADGFGCP-------GWVRISYCVDREMIKHSMPA 388 Query: 437 LKLL 440 + + Sbjct: 389 FEKI 392 >1C7O-A nrPDB Length = 399 Score = 223 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 78/404 (19%), Positives = 165/404 (40%), Gaps = 55/404 (13%) Query: 53 GRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTE 112 G E++ L + P I+ +K LD ++ PT ++ K + + Sbjct: 30 GNEVVPLSVADMEFKNPPELIEGLKKYLDETVLGYTGPTE---EYKKTVKKWMKDRHQWD 86 Query: 113 LKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPK 172 ++ + + T G + + + GD VI+ P + + I+ K++ + Sbjct: 87 IQTDWIINTAGVVPAVFNAVREFTKPGDGVIIITPVYYPFFMAIKNQERKIIECELLEKD 146 Query: 173 ELDQRNTRGEEWTIDFEQFEKAITSK-TKAVIINTPHNPIGKVFTREELTTLGNICVKHN 231 +TIDF++ EK K KA++ +PHNP+G+V+ ++EL + +I +K + Sbjct: 147 GY---------YTIDFQKLEKLSKDKNNKALLFCSPHNPVGRVWKKDELQKIKDIVLKSD 197 Query: 232 VVIISDEVYEHLYFTD-SFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAEL 290 +++ SDE++ L T ++ ++ T+T + K+F G + ++ N ++ Sbjct: 198 LMLWSDEIHFDLIMPGYEHTVFQSIDEQLADKTITFTAPSKTFNIAGMGMSNIIIKNPDI 257 Query: 291 LSYAAKAH--------TRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTS 342 K+ T + + + + C ++ +K+ I+K + Sbjct: 258 RERFTKSRDATSGMPFTTLGYKACEICYKECGKWLDGCIKV----------IDKNQRIVK 307 Query: 343 IFDELGLPYTAP---EGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVV 399 F E+ P EGTY +DF +K+ + E +++K + F ++ + G+ Sbjct: 308 DFFEVNHPEIKAPLIEGTYLQWIDFRALKM-DHKAMEEFMIHKAQIFFDEGYIFGDGGI- 365 Query: 400 AIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERL-KLLKD 442 R + + ++ ++ERL K LKD Sbjct: 366 -----------------GFERINLAAPSSVIQESLERLNKALKD 392 >3L8A-A nrPDB Length = 421 Score = 220 bits (561), Expect = 7e-58, Method: Composition-based stats. Identities = 82/395 (20%), Positives = 151/395 (38%), Gaps = 39/395 (9%) Query: 48 NSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSP 107 + EL+ + + P + ++ + + L ++I Sbjct: 55 KTSENNPELLQMWVADMDFLPVPEIKEA---IINYGREHIFGYNYFNDDLYQAVIDWERK 111 Query: 108 IYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVP 167 ++ + E++ G I L GD V++ P + + I L ++V Sbjct: 112 EHDYAVVKEDILFIDGVVPAISIALQAFSEKGDAVLINSPVYYPFARTIRLNDHRLV--- 168 Query: 168 INPPKELDQRNTRGEEWTIDFEQFEKAI-TSKTKAVIINTPHNPIGKVFTREELTTLGNI 226 L N R + IDFEQ EK I + K ++ +PHNP G+V+ ++L + + Sbjct: 169 ---ENSLQIINGR---FEIDFEQLEKDIIDNNVKIYLLCSPHNPGGRVWDNDDLIKIAEL 222 Query: 227 CVKHNVVIISDEVYEHL-YFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLS 285 C KH V+++SDE+++ L F ++ + TL T+ + SA K+F G + + + Sbjct: 223 CKKHGVILVSDEIHQDLALFGNTHHSLNTLDASYKDFTIILSSATKTFNIAGTKNSFAII 282 Query: 286 LNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIG--YFEKMRQEYINKFKIFTSI 343 N L K R + + + A + G + E+++ K+ Sbjct: 283 QNESLR---RKFQYRQLANNQHEVPTVGMIATQAAFQYGKPWLEELKTVIEGNIKLVIKE 339 Query: 344 FD-ELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIP 402 + + + PEGTY V +DFS I + ++S L NE VV Sbjct: 340 LEAKTKIKVMEPEGTYLVWLDFSAYAIAQP--------------QLSEKLQNEAKVVLND 385 Query: 403 PTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERL 437 F K + R V ++ A+ R+ Sbjct: 386 GAHFG-----KEGKYFARLNVATPKNTVQEALSRI 415 >3ASB-A nrPDB Length = 400 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 69/428 (16%), Positives = 142/428 (33%), Gaps = 56/428 (13%) Query: 23 NKYFTSNTAKDVWSLTNEAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDI 82 N +F S T +++ + A+ +N +INL G + + ++ Sbjct: 4 NPHFVSLTKNYLFADLQKRVAQ--FRLENPQHTVINLSIGDTTQPLNASVAEAFASSIAR 61 Query: 83 ----PMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNA 138 Y P G P+L L + Y + A+ + ++ GA + L Sbjct: 62 LSSPTTCRGYGPDFGLPALRQKLSE---DFYRGFVDAKEIFISDGAKVDLFRLL-SFFGP 117 Query: 139 GDEVIVFEPFFDQYIPNIELCGGK-VVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITS 197 V + +P + Y+ L G K ++ +P Q N E+ D + Sbjct: 118 NQTVAIQDPSYPAYLDIARLTGAKEIIALPCL------QENAFFPEFPED---------T 162 Query: 198 KTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSP 257 + + +P+NP G V +++L + + ++H ++I+ D Y S + P Sbjct: 163 HIDILCLCSPNNPTGTVLNKDQLRAIVHYAIEHEILILFDAAYSTFISDPSLPKSIFEIP 222 Query: 258 EIGQLTLTVGSAGKSFAATGWRIGWVLSLNAE-------LLSYAAKAHTRICFASPSPLQ 310 + + + S K G R+GW + ++ + + + P Q Sbjct: 223 DARFCAIEINSFSKPLGFAGIRLGWTVIPQELTYADGHFVIQDWERFLSTTFNGASIPAQ 282 Query: 311 EACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIP 370 EA ++ ++ Y + G E ++ V ++ I Sbjct: 283 EAGVAGLSILPQLEAI----HYYRENSDLLRKALLATGFEVFGGEHAPYLWVKPTQANI- 337 Query: 371 EDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYL 430 D + + + E + P F ++ +RF+ + Sbjct: 338 -------------SDRDLFDFFLREYHIAITPGIGFG-----RSGSGFVRFSSLGKREDI 379 Query: 431 ENAVERLK 438 A ERL+ Sbjct: 380 LAACERLQ 387 >3B1C-A nrPDB Length = 392 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 73/356 (20%), Positives = 135/356 (37%), Gaps = 23/356 (6%) Query: 55 ELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELK 114 +L+ + + + + Y T L+ +++ + Sbjct: 32 QLLPAWIADMDFEVMPEVKQAIHDYAEQLV---YGYTYASDELLQAVLDWEKSEHQYSFD 88 Query: 115 AENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKEL 174 E++ G I + G+ V++ P + + ++ L K+V + L Sbjct: 89 KEDIVFVEGVVPAISIAIQAFTKEGEAVLINSPVYPPFARSVRLNNRKLVSNSLKEENGL 148 Query: 175 DQRNTRGEEWTIDFEQFEKAITSK-TKAVIINTPHNPIGKVFTREELTTLGNICVKHNVV 233 + IDFEQ E I K ++ PHNP G+V+ RE L +G++C KH+V+ Sbjct: 149 ---------FQIDFEQLENDIVENDVKLYLLCNPHNPGGRVWEREVLEQIGHLCQKHHVI 199 Query: 234 IISDEVYEHLY-FTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLS 292 ++SDE+++ L F T+SP+ L + SA K+F G + + + N L + Sbjct: 200 LVSDEIHQDLTLFGHEHVSFNTVSPDFKDFALVLSSATKTFNIAGTKNSYAIIENPTLCA 259 Query: 293 YAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIF--DELGLP 350 S L + K + ++ + F + L Sbjct: 260 QFKHQQLVNNHHEVSSLGYIATETAYRYGKP-WLVALKAVLEENIQFAVEYFAQEAPRLK 318 Query: 351 YTAPEGTYFVLVDFSKVKIPED------YPYPEEILNKGKDFRISHWLINELGVVA 400 P+GTY + +DFS + +D + + ILN+G D+ L L + A Sbjct: 319 VMKPQGTYLIWLDFSDYGLTDDALFTLLHDQAKVILNRGSDYGSEGELHARLNIAA 374 >4FL0-A nrPDB Length = 456 Score = 213 bits (543), Expect = 8e-56, Method: Composition-based stats. Identities = 79/412 (19%), Positives = 141/412 (34%), Gaps = 62/412 (15%) Query: 49 SKNQGRELINLGQGFFSYSPPQFAIKEAQKALD----IPMVNQYSPTRGRPSLINSLIKL 104 K+ +LI+LG G + P+ + Y +G +L ++ + Sbjct: 65 EKHPNVQLISLGTGDTTEPIPEQITSHMSNFAHGLSTVEGYRGYGLEQGNKTLRKAIAET 124 Query: 105 YSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGG--- 161 + + +K+ V V+ GA I L LL + + V +P F YI + + G Sbjct: 125 FYR--DLHVKSNEVFVSDGAQSDISR-LQLLLGSNVTIAVQDPTFPAYIDSSVIIGQTGH 181 Query: 162 ---------KVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIG 212 VVY+P P + D A+T +T + +P+NP G Sbjct: 182 FHEKTKKYQNVVYMPCGPNNS----------FFPDL-----AMTPRTDVIFFCSPNNPTG 226 Query: 213 KVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKS 272 V +R++L L + + +II D Y S I P ++ + V S K Sbjct: 227 YVASRKQLHQLVDFAKTNGSIIIFDSAYAAFIEDGSPRSIYE-IPGAREVAIEVSSFSKF 285 Query: 273 FAATGWRIGWVLSLNAELLSYAAKA------HTRICFASPSPLQEACANSINDALKIGYF 326 TG R+GW + + L S F S + +A + + + Sbjct: 286 AGFTGVRLGWSIIPDELLYSNGFPIINDFHRIVTTSFNGASNIAQAGGLACLSSGGLKEI 345 Query: 327 EKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDF 386 + Y KI LGL ++ V F K + Sbjct: 346 RSVNNYYKENRKILMDTLVSLGLKVYGGVNAPYLWVHFKG----------------SKSW 389 Query: 387 RISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLK 438 + + ++ ++ +P + F E LR + ++ A +RL+ Sbjct: 390 DVFNEILENTHIITVPGSGFG-----PGGEEYLRISGFGRRDHIVEASKRLQ 436 >3QGU-A nrPDB Length = 449 Score = 210 bits (535), Expect = 8e-55, Method: Composition-based stats. Identities = 67/406 (16%), Positives = 134/406 (33%), Gaps = 39/406 (9%) Query: 44 KAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKAL----DIPMVNQYSPTRGRPSLIN 99 + A+ KN ++I+LG G + P++ KA + Y +G+ +L Sbjct: 59 RKAHQEKNPDAKIISLGIGDTTEPLPKYIADAMAKAAAGLATREGYSGYGAEQGQGALRE 118 Query: 100 SLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELC 159 ++ + A+ + ++ G+ I + + + V V +P + Y+ + Sbjct: 119 AVASTFYGHAGRA--ADEIFISDGSKCDIAR-IQMMFGSKPTVAVQDPSYPVYVDTSVMM 175 Query: 160 GGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREE 219 G + + D + +T + +P+NP G TR + Sbjct: 176 GMTGDHNGTGFDGIEYMVCNPDNHFFPDLSK-----AKRTDIIFFCSPNNPTGAAATRAQ 230 Query: 220 LTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWR 279 LT L N K+ +++ D Y + P ++ + S K TG R Sbjct: 231 LTELVNFARKNGSILVYDAAYALYISNPDCPKTIYEIPGADEVAIETCSFSKYAGFTGVR 290 Query: 280 IGWVLSLNAELLSYAAKAH------TRICFASPSPLQEACANSINDALKIGYFEKMRQEY 333 +GW + A + H CF S + +A + + M + Y Sbjct: 291 LGWTVVPKALKYANGEPVHADWNRVMTTCFNGASNIVQAGGLACLQPEGLKEMNAMIKFY 350 Query: 334 INKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLI 393 +I + F E+G + ++ V F + + ++ Sbjct: 351 KENAQILKTTFTEMGFSVYGGDDAPYIWVGFPG----------------KPSWDVFAEIL 394 Query: 394 NELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKL 439 +V P + + A E +R + + AV R K Sbjct: 395 ERCNIVTTPGSGYG-----PAGEGFVRASAFGSRENILEAVRRFKE 435 >1VP4-A nrPDB Length = 425 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 71/407 (17%), Positives = 142/407 (34%), Gaps = 55/407 (13%) Query: 54 RELINLGQGFFSYSP-PQFAIKEAQKALDIPMVN---QYSPTRGRPSLINSLIKLYSPIY 109 ++ I+ G G P+ + E K + + QYS T G P L ++KL +Y Sbjct: 43 KDAISFGGGVPDPETFPRKELAEIAKEIIEKEYHYTLQYSTTEGDPVLKQQILKLLERMY 102 Query: 110 NT-ELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPI 168 L +N+ T G+ + + L+ ++ +P + I V VP+ Sbjct: 103 GITGLDEDNLIFTVGSQQALDLIGKLFLDDESYCVLDDPAYLGAINAFRQYLANFVVVPL 162 Query: 169 NPPKELDQRNTRGEEWTIDFEQFEKAITSKTK---------AVIINTPHNPIGKVFTREE 219 E+ +D E+ ++ K +++ HNP G + E+ Sbjct: 163 -------------EDDGMDLNVLERKLSEFDKNGKIKQVKFIYVVSNFHNPAGVTTSLEK 209 Query: 220 LTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWR 279 L I K+++ I+ D+ Y L + + + + + K A G R Sbjct: 210 RKALVEIAEKYDLFIVEDDPYGALRYEGETVDPIFKI-GGPERVVLLNTFSKVLA-PGLR 267 Query: 280 IGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKI 339 IG +++ + E + +A SP+ A + + + + Y K + Sbjct: 268 IG-MVAGSKEFIRKIVQAKQSADLCSPAITHRLAARYLERYDLLEQLKPTIELYRRKRTV 326 Query: 340 FTSIFDE-----LGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLIN 394 + +E G+ + EG F+ + L +G D Sbjct: 327 MLNALEEYFSDIPGVKWVKSEGGLFIWL----------------TLPEGFDTWEMFEYAK 370 Query: 395 ELGVVAIPPTEFYIKEHEKAAENLLRFAVCK-DDAYLENAVERLKLL 440 V +P F + + + +R + C D + ++RL+ + Sbjct: 371 RKKVFYVPGRVFKVYDEPSPS---MRLSFCLPPDEKIVEGIKRLREV 414 >1M4N-A nrPDB Length = 435 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 70/397 (17%), Positives = 147/397 (37%), Gaps = 37/397 (9%) Query: 58 NLGQGFFSYSPPQFAIKEAQKAL--DIPMVNQYSPTRGRPSLINSLIKLYSPIYN--TEL 113 +L + + + +P A K+ +++ ++ + Y G P+ +++ + I Sbjct: 53 DLLESWLAKNPEAAAFKKNGESIFAELALFQDY---HGLPAFKKAMVDFMAEIRGNKVTF 109 Query: 114 KAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIEL-CGGKVVYVPINPPK 172 ++ +T GA + + L + G+ V++ P++ + +++ G ++V + Sbjct: 110 DPNHLVLTAGATSANETFIFCLADPGEAVLIPTPYYPGFDRDLKWRTGVEIVPIHCTSSN 169 Query: 173 ELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNV 232 T EE + E+ + K V++ P NP+G TR EL L + + Sbjct: 170 GFQITETALEEAYQEAEK----RNLRVKGVLVTNPSNPLGTTMTRNELYLLLSFVEDKGI 225 Query: 233 VIISDEVYEHLYF-TDSFTRIATL--------SPEIGQLTLTVGSAGKSFAATGWRIGWV 283 +ISDE+Y F + SF + + + E+ Q V S K G+R+G Sbjct: 226 HLISDEIYSGTAFSSPSFISVMEVLKDRNCDENSEVWQRVHVVYSLSKDLGLPGFRVG-A 284 Query: 284 LSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSI 343 + N +++ AA + S A + L Y + + + K S Sbjct: 285 IYSNDDMVVAAATKMSSFGLVSSQTQHLLSAMLSDKKLTKNYIAENHKRLKQRQKKLVSG 344 Query: 344 FDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPP 403 + G+ F VD + + + + ++ E+ + P Sbjct: 345 LQKSGISCLNGNAGLFCWVDMRHLLRSNTFEA---------EMELWKKIVYEVHLNISPG 395 Query: 404 TEFYIKEHEKAAENLLRFAVCK-DDAYLENAVERLKL 439 + + E R + L+ A++RLK Sbjct: 396 SSCHCTEP-----GWFRVCFANLPERTLDLAMQRLKA 427 >3OP7-A nrPDB Length = 375 Score = 204 bits (518), Expect = 7e-53, Method: Composition-based stats. Identities = 86/374 (22%), Positives = 135/374 (36%), Gaps = 61/374 (16%) Query: 74 KEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLM 133 ++ K L +N Y G P+ S+ +LY T +K E + T GA L L Sbjct: 46 EDFYKKLQGTKLN-YGWIEGSPAFKKSVSQLY-----TGVKPEQILQTNGATGANLLVLY 99 Query: 134 GLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEK 193 L+ GD VI P + Q + G +V I W D E+ + Sbjct: 100 SLIEPGDHVISLYPTYQQLYDIPKSLGAEVDLWQIEEEN----------GWLPDLEKLRQ 149 Query: 194 AITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIA 253 I TK + IN +NP G V R L L I + I+SDEVY D + I Sbjct: 150 LIRPTTKMICINNANNPTGAVMDRTYLEELVEIASEVGAYILSDEVYRSFSELDVPSII- 208 Query: 254 TLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEAC 313 E+ + V S K+++ G RIGWV + + C Sbjct: 209 ----EVYDKGIAVNSLSKTYSLPGIRIGWVAANH----------QVTDILRDYRDYTMIC 254 Query: 314 ANSIND---ALKIGYFEKMRQEYINKFKIFTSIF-----DELGLPYTAPEGTYFVLVDFS 365 A +D L + +++++ + + + +I +E + Y P +V S Sbjct: 255 AGVFDDLVAQLALAHYQEILERNRHILEENLAILDQWIEEEPLVSYIRP-----AVVSTS 309 Query: 366 KVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCK 425 VKI D P + L+ E GV+ +P F + +R Sbjct: 310 FVKIAVDMPMED----------FCLQLLQEHGVLLVPGNRF-------ERDGYVRLGFAC 352 Query: 426 DDAYLENAVERLKL 439 + L +E+L Sbjct: 353 EQETLIKGLEKLSQ 366 >2ZYJ-A nrPDB Length = 397 Score = 200 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 76/371 (20%), Positives = 134/371 (36%), Gaps = 50/371 (13%) Query: 83 PMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEV 142 + QYSPT G L + + ++ E V +TTG+ + + L+ G V Sbjct: 65 EVALQYSPTEGYAPLRAFVAEW------IGVRPEEVLITTGSQQALDLVGKVFLDEGSPV 118 Query: 143 IVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTK-- 200 ++ P + I L G + + VP D + E+ + + Sbjct: 119 LLEAPSYMGAIQAFRLQGPRFLTVPAGEEG-------------PDLDALEEVLKRERPRF 165 Query: 201 AVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTD-SFTRIATLSPEI 259 +I + NP G + L + ++ +V++ D+ Y LYF + + L+ E Sbjct: 166 LYLIPSFQNPTGGLTPLPARKRLLQMVMERGLVVVEDDAYRELYFGEARLPSLFELAREA 225 Query: 260 G-QLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSIN 318 G + +GS K + G R+ + ++ + E L +A +P L + + + Sbjct: 226 GYPGVIYLGSFSKVLS-PGLRVAFAVA-HPEALQKLVQAKQGADLHTPM-LNQMLVHELL 282 Query: 319 DALKIGYFEKMRQEYINKFKIFTSIFDE---LGLPYTAPEGTYFVLVDFSKVKIPEDYPY 375 E++R+ Y K + D + YT P+G FV ++ Sbjct: 283 KEGFSERLERVRRVYREKAQAMLHALDREVPKEVRYTRPKGGMFVWME------------ 330 Query: 376 PEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCK-DDAYLENAV 434 L KG E V +P F+ EN LR + D + V Sbjct: 331 ----LPKGLSAEGLFRRALEENVAFVPGGPFFANG---GGENTLRLSYATLDREGIAEGV 383 Query: 435 ERL-KLLKDYL 444 RL + LK L Sbjct: 384 RRLGRALKGLL 394 >5Z0Q-C nrPDB Length = 389 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 63/389 (16%), Positives = 132/389 (33%), Gaps = 41/389 (10%) Query: 54 RELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTEL 113 R+++ L + I Q+ + + Y T +L I+ + ++ Sbjct: 33 RDILPLWIADTDFRAADCIIDALQQRVQQGVF-GYGVTS--EALAEVAIERMESRFGWKI 89 Query: 114 KAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKE 173 + E + G GI + A + P + + +L G + + + + Sbjct: 90 QPEWLVFLPGVVTGINIAVRAFTEAHQSTVSATPIYPPFFLAPKLAGRQHLSAALRLEQ- 148 Query: 174 LDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVV 233 + W +D + E ++ K +++ PHNP G V+ R+EL +H+++ Sbjct: 149 --------QRWVLDLDSHEDRMSGNEKLLLLCNPHNPGGTVYRRKELEAQLRFAQRHDLL 200 Query: 234 IISDEVYEHLYFTDS--FTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELL 291 + SDE++ L A+LS + Q ++T+ S KSF G + N EL Sbjct: 201 VCSDEIHCDLVLEPGVQHIPFASLSDDAAQRSITLMSPSKSFNIAGLGASLAVIPNPELR 260 Query: 292 SYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDEL-GLP 350 + + + A + + + + + + + L GL Sbjct: 261 ARFNRMRKGMVPDVDVLAYVAASAAWREGQP--WLDAQLDYLRANRDMLAQHVNRLPGLS 318 Query: 351 YTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKE 410 PE ++ +D S + + + + G+ +F Sbjct: 319 MVTPEASFLGWIDASGLGVADPA-----------------LFFEKHGLGFSSGRDFGND- 360 Query: 411 HEKAAENLLRFAVCKDDAYLENAVERLKL 439 +RF LE A++R+ Sbjct: 361 ------RFVRFNFGCPRQLLEEALQRMTR 383 >3NRA-A nrPDB Length = 407 Score = 198 bits (502), Expect = 6e-51, Method: Composition-based stats. Identities = 64/391 (16%), Positives = 140/391 (35%), Gaps = 32/391 (8%) Query: 57 INLGQGFFS-YSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKA 115 ++ G + P A + V Y+ RG + + L + + A Sbjct: 42 VDFSHGDVDAHEPTPGAFDLFSAGVQSGGVQAYTEYRGDLGIRDLLAPRLAAFTGAPVDA 101 Query: 116 EN-VTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKEL 174 + + +T G + + + GD+V + +P + +E G++V V +L Sbjct: 102 RDGLIITPGTQGALFLAVAATVARGDKVAIVQPDYFANRKLVEFFEGEMVPV------QL 155 Query: 175 DQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVI 234 D + +D E+A + + + + P+NP G V++ EE+ + + ++ + Sbjct: 156 DYVSADETRAGLDLTGLEEAFKAGARVFLFSNPNNPAGVVYSAEEIGQIAALAARYGATV 215 Query: 235 ISDEVYEHLYFTD-SFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSY 293 I+D++Y L + S+T + + + +T+ K+ + +G+R+G A +++ Sbjct: 216 IADQLYSRLRYAGASYTHLRAEAAVDAENVVTIMGPSKTESLSGYRLGVAFGSRA-IIAR 274 Query: 294 AAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFD-ELGLPYT 352 K + + Q ++A G+ E + + G+ Sbjct: 275 MEKLQAIVSLRAAGYSQAVLRGWFDEA--PGWMEDRIARHQAIRDELLHVLRGCEGVFAR 332 Query: 353 APEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHE 412 P+ ++ K+ + L + GVV P TEF Sbjct: 333 TPQAGSYLFPRLPKLAVAPA--------------EFVKILRLQAGVVVTPGTEF-----S 373 Query: 413 KAAENLLRFAVCKDDAYLENAVERLKLLKDY 443 + +R +D A R+ L + Sbjct: 374 PHTADSVRLNFSQDHEAAVAAARRIVTLVER 404 >1IAY-A nrPDB Length = 428 Score = 196 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 64/361 (17%), Positives = 132/361 (36%), Gaps = 34/361 (9%) Query: 92 RGRPSLINSLIKLYSPIYN--TELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFF 149 G P ++ K E V + GA + + L + GD +V P++ Sbjct: 83 HGLPEFRKAIAKFMEKTRGGRVRFDPERVVMAGGATGANETIIFCLADPGDAFLVPSPYY 142 Query: 150 DQYIPNIEL-CGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITS--KTKAVIINT 206 + ++ G +++ + + + E +E A S K K +I+ Sbjct: 143 PAFNRDLRWRTGVQLIPIHCESSNNFKITSKAVK------EAYENAQKSNIKVKGLILTN 196 Query: 207 PHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFT-DSFTRIATLSPE------I 259 P NP+G ++ L ++ + +HN+ ++ DE+Y F F IA + E Sbjct: 197 PSNPLGTTLDKDTLKSVLSFTNQHNIHLVCDEIYAATVFDTPQFVSIAEILDEQEMTYCN 256 Query: 260 GQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSIND 319 L V S K G+R+G + S N ++++ A K + ++ + A S ++ Sbjct: 257 KDLVHIVYSLSKDMGLPGFRVGIIYSFNDDVVNCARKMSSFGLVSTQTQYFLAAMLS-DE 315 Query: 320 ALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEI 379 + + + K FT+ + +G+ F +D + Sbjct: 316 KFVDNFLRESAMRLGKRHKHFTNGLEVVGIKCLKNNAGLFCWMDLRPL---------LRE 366 Query: 380 LNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCK-DDAYLENAVERLK 438 + + +IN++ + P + F +E R DD ++ A+ R++ Sbjct: 367 STFDSEMSLWRVIINDVKLNVSPGSSFECQEP-----GWFRVCFANMDDGTVDIALARIR 421 Query: 439 L 439 Sbjct: 422 R 422 >3EI8-A nrPDB Length = 432 Score = 196 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 78/409 (19%), Positives = 138/409 (33%), Gaps = 42/409 (10%) Query: 44 KAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALD----IPMVNQYSPTRGRPSLIN 99 ++A+ K ++I+LG G + P+ K I + Y +G L Sbjct: 46 RSAHLLKYPDAQVISLGIGDTTEPIPEVITSAMAKKAHELSTIEGYSGYGAEQGAKPLRA 105 Query: 100 SLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELC 159 ++ K + + ++V V+ GA I L + + + V +P + Y+ + + Sbjct: 106 AIAKTFYG--GLGIGDDDVFVSDGAKCDISR-LQVMFGSNVTIAVQDPSYPAYVDSSVIM 162 Query: 160 GGKVVY-VPINPPKELDQRNTRGEE-WTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTR 217 G + + ++ E + D +T + +P+NP G TR Sbjct: 163 GQTGQFNTDVQKYGNIEYMRCTPENGFFPDLSTV-----GRTDIIFFCSPNNPTGAAATR 217 Query: 218 EELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATG 277 E+LT L K+ +I+ D Y +Y +D R P ++ + S TG Sbjct: 218 EQLTQLVEFAKKNGSIIVYDSAYA-MYMSDDNPRSIFEIPGAEEVAMETASFSNYAGFTG 276 Query: 278 WRIGWVLSLNAELLSY---AAKAHTRI---CFASPSPLQEACANSINDALKIGYFEKMRQ 331 R+GW + L S AK RI CF S + +A A + + K+ Sbjct: 277 VRLGWTVIPKKLLYSDGFPVAKDFNRIICTCFNGASNISQAGALACLTPEGLEAMHKVIG 336 Query: 332 EYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHW 391 Y I F LG + +V V F + + Sbjct: 337 FYKENTNIIIDTFTSLGYDVYGGKNAPYVWVHFP----------------NQSSWDVFAE 380 Query: 392 LINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLL 440 ++ + VV E +R + + A R K L Sbjct: 381 ILEKTHVVTT-----PGSGFGPGGEGFVRVSAFGHRENILEACRRFKQL 424 >6HNV-A nrPDB Length = 524 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 82/405 (20%), Positives = 148/405 (36%), Gaps = 58/405 (14%) Query: 78 KALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLN 137 K +D+ QY+ G L+ + NV +TTGA++G+ L+ Sbjct: 120 KLIDLARGLQYAAVEGHAPLLQFARDFIIRTHKPNYDDWNVFITTGASDGLNKAADVFLD 179 Query: 138 AGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAIT- 196 GD ++V E F ++ + G K V V IN + D + ++ E +EK Sbjct: 180 DGDVILVEEFTFSPFLRFSDNAGAKAVPVKINFDNDSDGIDLT--QFVDLLENWEKHYPN 237 Query: 197 -SKTKAVI-INTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLY---------- 244 K KA+ I T NP G + E + ++ VK++ II D+ Y +L Sbjct: 238 LPKPKALYTIATGQNPTGFTQSLEFRKKIYDLAVKYDFAIIEDDPYGYLTLPKYEKPNIG 297 Query: 245 -----------------FTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLN 287 + + + L + L V + K FA G R+G+++ + Sbjct: 298 GSGSGNNELKNDLEIDDYLKNHLTPSYLELDTTGRVLRVETFSKLFA-PGLRLGFIVG-H 355 Query: 288 AELLSYAAKAHTRICFASPSPLQEACANSINDALK-----IGYFEKMRQEYINKFKIFT- 341 E++ + + Q N I + K + + KMR Y + + Sbjct: 356 KEVIDAVKNYSDVVNRGASGLTQTIVNNVIQENFKGVDGWLEWILKMRLNYSYRKDLLLY 415 Query: 342 SIFDELGLP-----YTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINEL 396 SIF+ P+ FV K+ +P+D ++ ++ W + Sbjct: 416 SIFESQAYKKGYVDVIDPKAGMFVTF---KINLPKDVDVLQK-------MKLLLWKLISY 465 Query: 397 GVVAIPPTEFYIK-EHEKAAENLLRFAV--CKDDAYLENAVERLK 438 G++ +P + E K N R +D + + +RL Sbjct: 466 GILVVPGYNMTVDLEFSKDRSNFFRLCYALANNDEEILESGKRLT 510 >4GDY-A nrPDB Length = 439 Score = 195 bits (494), Expect = 5e-50, Method: Composition-based stats. Identities = 72/417 (17%), Positives = 151/417 (36%), Gaps = 57/417 (13%) Query: 54 RELINLGQGFFSYS---------------PPQFAIKEAQKALDIPMVNQYSPTRGRPSLI 98 + +I+L G + + QF + ++AL QYSP+ G P L+ Sbjct: 31 KSMISLAGGLPNPNMFPFKTAVITVENGKTIQFGEEMMKRAL------QYSPSAGIPELL 84 Query: 99 NSLIKLYSPIYNTE-------LKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQ 151 + L +L ++N ++ VT+G+ +G+ ++N GD V++ EP + Sbjct: 85 SWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQGLCKVFEMIINPGDNVLLDEPAYSG 144 Query: 152 YIPNIELCGGKVVYVPINPPKELDQRNTR-GEEWTIDFEQFEKAITSKTKAVIINTPHNP 210 + ++ G ++ V + + W + + + T K + +NP Sbjct: 145 TLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKPEDAKNPQKNTPKF-LYTVPNGNNP 203 Query: 211 IGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAG 270 G T E + + K++ +II D+ Y L F LS ++ + S Sbjct: 204 TGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNSGRVPTF-LSMDVDGRVIRADSFS 262 Query: 271 KSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGY---FE 327 K + +G RIG++ L+ + Q + +++ + G+ + Sbjct: 263 KIIS-SGLRIGFLTGPKP-LIERVILHIQVSTLHPSTFNQLMISQLLHEWGEEGFMAHVD 320 Query: 328 KMRQEYINKFKIFTSIFDE--LGL-PYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGK 384 ++ Y N+ + D+ GL + P F+ + + Sbjct: 321 RVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGIN---------------D 365 Query: 385 DFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDD-AYLENAVERLKLL 440 + ++GV+ +P FY+ + LR + ++ A + L L Sbjct: 366 VKELIEEKAVKMGVLMLPGNAFYVDSSAPSP--YLRASFSSASPEQMDVAFQVLAQL 420 >3IHJ-A nrPDB Length = 498 Score = 194 bits (492), Expect = 7e-50, Method: Composition-based stats. Identities = 80/415 (19%), Positives = 159/415 (38%), Gaps = 60/415 (14%) Query: 64 FSYSPPQFAIKEAQKALDI---PMVNQYSPTRGRPSLINSLIKLYSPIYN-TELKAENVT 119 S+ P+ A K A++ L + YS ++G + + + +N+ Sbjct: 100 PSF--PEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIY 157 Query: 120 VTTGANEGILSCLMGLLNAGDE----VIVFEPFFDQYIPNIELCGGKVVYVPINPPKELD 175 +TTGA++GI + L L++ G + V++ P + Y I I LD Sbjct: 158 LTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDA------IQVNYYLD 211 Query: 176 QRNTRGEEWTIDFEQFEKAITS-----KTKAVIINTPHNPIGKVFTREELTTLGNICVKH 230 + N W ++ + +A+ K + I P NP G+V +R+ + + + + Sbjct: 212 EENC----WALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEE 267 Query: 231 NVVIISDEVYEHLYFTDSF------TRIATLSPEIGQLT--LTVGSAGK-SFAATGWRIG 281 + +++DEVY+ ++ + + PE + S K G+R G Sbjct: 268 KLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGG 327 Query: 282 W--VLSLNAELLSYAAK-AHTRICFASPSPLQEACANSINDALKIGY--FEKMRQE---- 332 + V++L+ E+ K R+C P +A + + + G FE+ +E Sbjct: 328 YMEVINLHPEIKGQLVKLLSVRLC---PPVSGQAAMDIVVNPPVAGEESFEQFSREKESV 384 Query: 333 ---YINKFKIFTSIFDE-LGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRI 388 K K+ +F++ G+ +G + F ++ IP + D Sbjct: 385 LGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYA---FPRIFIPAKAVEAAQAHQMAPDMFY 441 Query: 389 SHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLKDY 443 L+ E G+ +P + F +E R + L+ L+ +KD+ Sbjct: 442 CMKLLEETGICVVPGSGFGQRE----GTYHFRMTILPPVEKLKTV---LQKVKDF 489 >3DZZ-A nrPDB Length = 391 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 63/389 (16%), Positives = 138/389 (35%), Gaps = 34/389 (8%) Query: 54 RELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTEL 113 + + + + + ++ L + S ++ + Sbjct: 27 EKELPMWIAEMDFKIAPEIMASMEEKLKVAAFGYESVPA---EYYKAVADWEEIEHRARP 83 Query: 114 KAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKE 173 K + +G I + + + GD+++V EP ++ + IE G +V+ + Sbjct: 84 KEDWCVFASGVVPAISAMVRQFTSPGDQILVQEPVYNMFYSVIEGNGRRVI------SSD 137 Query: 174 LDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVV 233 L N++ D E EK T + ++ PHNPIG ++ EE+ + +C KH V+ Sbjct: 138 LIYENSKYSVNWADLE--EKLATPSVRMMVFCNPHNPIGYAWSEEEVKRIAELCAKHQVL 195 Query: 234 IISDEVYEHLYFTD-SFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLS 292 +ISDE++ L TD T T+ + +++ S K+F + N +L + Sbjct: 196 LISDEIHGDLVLTDEDITPAFTVDWDAKNWVVSLISPSKTFNLAALHAACAIIPNPDLRA 255 Query: 293 YAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDE--LGLP 350 A ++ P+ L A + + + +++Q + F + + Sbjct: 256 RAEESFFLAGIGEPNLLAIPAAIAAYEEGH-DWLRELKQVLRDNFAYAREFLAKEVPEVK 314 Query: 351 YTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKE 410 +Y VD S + + + +L + G++ + Sbjct: 315 VLDSNASYLAWVDISALGMNAE--------------DFCKYLREKTGLIISAGNGY---- 356 Query: 411 HEKAAENLLRFAVCKDDAYLENAVERLKL 439 +R + + + ++RLK Sbjct: 357 -RGNGHEFVRINLACPKELVIDGMQRLKQ 384 >3EZS-A nrPDB Length = 376 Score = 188 bits (476), Expect = 5e-48, Method: Composition-based stats. Identities = 79/425 (18%), Positives = 156/425 (36%), Gaps = 59/425 (13%) Query: 24 KYFTSNTAKDVWSLTNEAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIP 83 F + + +L E K ++LG G + P+F + Sbjct: 2 MTFEPYPFERLRALLKEITPKKRG---------LDLGIGEPQFETPKFIQDALKN--HTH 50 Query: 84 MVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCL-MGLLNAGD-E 141 +N Y + SL + + + ELK + T G+ E + + L + + Sbjct: 51 SLNIYPKSAFEESLRAAQRGFFKRRFKIELKENELISTLGSREVLFNFPSFVLFDYQNPT 110 Query: 142 VIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKA 201 + PF+ Y + K + +P+ T+ ++T + E + Sbjct: 111 IAYPNPFYQIYEGAAKFIKAKSLLMPL----------TKENDFTPSLNEKELQ---EVDL 157 Query: 202 VIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSP---- 257 VI+N+P+NP G+ + EEL + + +KH+ ++I+DE Y +Y + Sbjct: 158 VILNSPNNPTGRTLSLEELISWVKLALKHDFILINDECYSEIYENTPPPSLLEACMLAGN 217 Query: 258 EIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSI 317 E + L + S K +A G R G++ ++ LL + + S + +Q+A + Sbjct: 218 EAFKNVLVIHSLSKRSSAPGLRSGFIAG-DSRLLEKYKAFRAYLGYTSANAIQKASEAAW 276 Query: 318 NDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPE 377 D +F R Y N K+ IF + +++V Sbjct: 277 LDDRHAEFF---RNIYANNLKLARKIFKNTLIYPY----SFYVY---------------- 313 Query: 378 EILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERL 437 L + L G++ +P Y+ + A+ +R A+ D LE +E + Sbjct: 314 --LPVQNGENFAKTLYQNEGIITLP--ALYLGRNRIGAD-YVRLALVYDTPLLEKPLEII 368 Query: 438 KLLKD 442 + ++ Sbjct: 369 ETYRE 373 >4JE5-A nrPDB Length = 503 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 82/420 (19%), Positives = 136/420 (32%), Gaps = 68/420 (16%) Query: 70 QFAIKEAQKALDIPMVN--QYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEG 127 +A K A + DIP+ QY + G+P L+N + I++ + K +V T G Sbjct: 88 DYADKSANPSNDIPLSRALQYGFSAGQPELLNFIRDHTKIIHDLKYKDWDVLATAGNTNA 147 Query: 128 ILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTR-GEEWTI 186 S L N GD ++V F + + E G VPI+ + ++ + E WT Sbjct: 148 WESTLRVFCNRGDVILVEAHSFSSSLASAEAQGVITFPVPIDADGIIPEKLAKVMENWTP 207 Query: 187 DFEQFEKAITSKTKAVI-INTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYF 245 K K + I T NP G + I K++ +I+ DE Y L Sbjct: 208 G--------APKPKLLYTIPTGQNPTGTSIADHRKEAIYKIAQKYDFLIVEDEPYYFLQM 259 Query: 246 TDSFTRIAT-----------------------LSPEIGQLTLTVGSAGKSFAATGWRIGW 282 + LS + + + S K A G R+GW Sbjct: 260 NPYIKDLKEREKAQSSPKQDHDEFLKSLANTFLSLDTEGRVIRMDSFSKVLA-PGTRLGW 318 Query: 283 VLSLNAELLSYAAKAHTRICFASPSPLQEACANS----INDALKIGYFEKMRQEYINKFK 338 + + L Y + I +P+ + N+ + + +R EY K Sbjct: 319 ITGSSKILKPYLSLHEMTI--QAPAGFTQVLVNATLSRWGQKGYLDWLLGLRHEYTLKRD 376 Query: 339 IFTSIF-----DELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWL- 392 P F V+ PE + +++ L Sbjct: 377 CAIDALYKYLPQSDAFVINPPIAGMFFTVNIDASVHPE-----FKTKYNSDPYQLEQSLY 431 Query: 393 --INELGVVAIPPTEF---YIKEHEKAAEN---------LLRFAVCK-DDAYLENAVERL 437 + E GV+ +P + F E + AE+ R L ++RL Sbjct: 432 HKVVERGVLVVPGSWFKSEGETEPPQPAESKEVSNPNIIFFRGTYAAVSPEKLTEGLKRL 491 >6HNB-A nrPDB Length = 491 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 83/431 (19%), Positives = 150/431 (34%), Gaps = 72/431 (16%) Query: 60 GQGFFSYSPPQFAIKEAQKA-------LDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTE 112 G G + I+ +KA +++ QY T G P + + + ++ Sbjct: 70 GIGAPIEGENKTTIEVFKKAADNVPDQIELARSLQYGSTFGLPEFLQFIKEHTDMVHKVP 129 Query: 113 LKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPK 172 + +V V+ G E S L + GD ++V E F + + G V V ++ Sbjct: 130 YENWDVIVSVGNTEAWDSTLRTFCSKGDTILVEEYTFSSALESANGQGVNTVPVTMD--- 186 Query: 173 ELDQRNTRGEEWTIDFEQFEKAITS----KTKAVI-INTPHNPIGKVFTREELTTLGNIC 227 E+ I E+ E+ ++ K K + I T NP G + E + +I Sbjct: 187 ----------EFGIIPEKLEELMSRWVGNKPKFLYTICTGQNPTGSSLSAERRKQIYDIA 236 Query: 228 VKHNVVIISDEVYEHLYFT-----------------DSFTR---IATLSPEIGQLTLTVG 267 K++ +II DE Y L D F + + +S ++ + + Sbjct: 237 CKYDFLIIEDEPYYFLQMETYTKDKAAREGKAVHDHDEFLKALVPSFISLDVEGRVVRLD 296 Query: 268 SAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSI----NDALKI 323 S K A G R+GW++ +LL + H + +PS EA AN++ + + Sbjct: 297 SFSKVLA-PGLRLGWIVGQ-KDLLERYVRLHE-VSVQNPSGFSEALANALLRKWGHSGYL 353 Query: 324 GYFEKMRQEYINKFKIFTSIFDELGLP----YTAPEGTYFVLVDFSKVKIPEDYPYPEEI 379 + +R EY +K + D+ + P F V K P+ + E+ Sbjct: 354 DWLIGLRAEYTHKRDVAIDALDQFVPKEVSSFNPPVAGMFFTVTLDASKHPKYKEFLEDP 413 Query: 380 LNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAEN------------LLRFAVCK-D 426 L K H + G + P + F + + R Sbjct: 414 L---KVEAAVHEQAIKQGCLLAPGSWFKAEGQSSPPQKNLPANPSHKTHIFFRGTYAAVP 470 Query: 427 DAYLENAVERL 437 L +E+ Sbjct: 471 LDQLVVGLEKF 481 >4M2J-A nrPDB Length = 406 Score = 183 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 72/352 (20%), Positives = 125/352 (35%), Gaps = 36/352 (10%) Query: 89 SPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPF 148 S ++G + ++ Y+ A+ V VT G++E I L LL+ GD V+V E Sbjct: 81 SVSQGGEGVRRAIADRYAGG-----DADRVLVTHGSSEAIALTLNALLHRGDRVVVQEGI 135 Query: 149 FDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPH 208 + G V +P + ID + +T T AVI+N PH Sbjct: 136 YHSLGHYPRAAGCDVAVLP----------GRAVRDGEIDPDVLAGLVTPGTAAVIVNFPH 185 Query: 209 NPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGS 268 NP G + + L L V++ D + + +A + G T++ G+ Sbjct: 186 NPTGVTLSPQGLRALKERTAATGAVLVWDAATAEI--AHRWEVLADPGADGGD-TVSYGT 242 Query: 269 AGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALK-IGYFE 327 K+F G R+GW ++ ELL+ R ++ ++ A + IG Sbjct: 243 LSKTFGLPGLRVGWAVAP-KELLTATFPLRDRTTLFLSPLVELVAERAVRHADELIGARA 301 Query: 328 KMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFR 387 + + + + +EL + +T PEG L F +++ P E R Sbjct: 302 AEARHNLAHLTGWMAAHEEL-VRWTPPEGGVCALPVFRELERAAAGPQEVE--------R 352 Query: 388 ISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKL 439 L+ + +P T F R ++ L Sbjct: 353 FCLELLERHRTLLVPGTAFGAPHGA-------RLGFGGPQEDFRAGLDGLSR 397 >3TCM-A nrPDB Length = 500 Score = 180 bits (457), Expect = 9e-46, Method: Composition-based stats. Identities = 73/390 (18%), Positives = 147/390 (37%), Gaps = 34/390 (8%) Query: 74 KEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLM 133 K+ + YS ++G L +++ + A+++ +T GA+ G+ + Sbjct: 116 KQILAMIPGRATGAYSHSQGIHGLRDAIASGIASRDGFPANADDIFLTDGASPGVHLMMQ 175 Query: 134 GLL-NAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFE 192 L+ N D ++V P + Y +I L GG +V L++ G E + +Q E Sbjct: 176 LLIRNEKDGILVPIPQYPLYSASIALHGGALVPY------YLNESTGWGLETSDVKKQLE 229 Query: 193 KAITS--KTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTD--S 248 A + +A+++ P NP G+V E + C +V+++DEVY+ + D Sbjct: 230 DARSRGINVRALVVINPGNPTGQVLAEENQYDIVKFCKNEGLVLLADEVYQENIYVDNKK 289 Query: 249 FTRIATLSPEIGQL-----TLTVGSAGK-SFAATGWRIGW--VLSLNAELLSYAAK-AHT 299 F + +G ++ S K + G R G+ + +A + K A Sbjct: 290 FHSFKKIVRSLGYGEEDLPLVSYQSVSKGYYGECGKRGGYFEITGFSAPVREQIYKIASV 349 Query: 300 RICFASPSPLQEACANSINDALKIGYF------EKMRQEYINKFKIFTSIFDEL-GLPYT 352 +C + + + A Y + + + K F++L G+ Sbjct: 350 NLCSNITGQILASLVMNPPKASDESYASYKAEKDGILASLARRAKALEHAFNKLEGITCN 409 Query: 353 APEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHE 412 EG +V F ++ +P+ + NK D + L+ G+V +P + F Sbjct: 410 EAEGAMYV---FPQICLPQKAIEAAKAANKAPDAFYALRLLESTGIVVVPGSGFGQVP-- 464 Query: 413 KAAENLLRFAVCKDDAYLENAVERLKLLKD 442 R + + + + R + + Sbjct: 465 --GTWHFRCTILPQEDKIPAVISRFTVFHE 492 >3FDB-A nrPDB Length = 377 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 60/404 (14%), Positives = 130/404 (32%), Gaps = 41/404 (10%) Query: 38 TNEAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSL 97 + A+ G+ ++ L +S ++ A+ Y P L Sbjct: 7 IEDLRARNTMKWTRYGQGVLPLWVAESDFSTCPAVLQAITDAVQREAF-GYQPDGSL--L 63 Query: 98 INSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIE 157 + + Y+ Y + + E + G+ + A +VIV P + + + Sbjct: 64 SQATAEFYADRYGYQARPEWIFPIPDVVRGLYIAIDHFTPAQSKVIVPTPAYPPFFHLLS 123 Query: 158 LCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTR 217 + +++ I+ EK + +++++ P+NP+G VF Sbjct: 124 ATQREGIFIDAT--------------GGINLHDVEKGFQAGARSILLCNPYNPLGMVFAP 169 Query: 218 EELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATG 277 E L L ++ +++ ++ DE++ L F T A +S + +T+ + K++ G Sbjct: 170 EWLNELCDLAHRYDARVLVDEIHAPLVFDGQHTVAAGVSDTAASVCITITAPSKAWNIAG 229 Query: 278 WRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKF 337 + ++ N + + + + S L A + + + N Sbjct: 230 LKCAQIIFSNPSDAEHWQQL-SPVIKDGASTLGLIAAEAAYRYGT-DFLNQEVAYLKNNH 287 Query: 338 KIFTSIFDE--LGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINE 395 + G T + TY + +DF I S + I + Sbjct: 288 DFLLHEIPKRIPGAKITPMQATYLMWIDFRDTTIEGSP---------------SEFFIEK 332 Query: 396 LGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKL 439 V F + R LE A++R+ Sbjct: 333 AKVAMNDGAWFG-----EDGTGFCRLNFATSREVLEEAIDRMAK 371 >3CQ5-A nrPDB Length = 369 Score = 174 bits (441), Expect = 6e-44, Method: Composition-based stats. Identities = 78/407 (19%), Positives = 154/407 (37%), Gaps = 57/407 (14%) Query: 37 LTNEAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDI--PMVNQYSPTRGR 94 L E + A + + I L Y P + + + +D +N+Y P R Sbjct: 14 LREELRGEHAYGAPQLNVD-IRLNTNENPYPPSEALVADLVATVDKIATELNRY-PERDA 71 Query: 95 PSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIP 154 L + L + + +N+ G+NE + L G + F+P + + Sbjct: 72 VELRDELAAYITKQTGVAVTRDNLWAANGSNEILQQLLQAFGGPGRTALGFQPSYSMHPI 131 Query: 155 NIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFE-QFEKAITSKTKAVIINTPHNPIGK 213 + + + V +RG ++ ID + E+ + V + TP+NP G Sbjct: 132 LAKGTHTEFIAV------------SRGADFRIDMDVALEEIRAKQPDIVFVTTPNNPTGD 179 Query: 214 VFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSF 273 V + +++ + N+ ++I DE Y + S T + P + + K+F Sbjct: 180 VTSLDDVERIINVAPG---IVIVDEAYAEFSPSPSATTLLEKYPT---KLVVSRTMSKAF 233 Query: 274 AATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSI-NDALKIGYFEKMRQE 332 G R+G+ ++ A + + R+ + + Q A ++ + A +G EK+ E Sbjct: 234 DFAGGRLGYFVANPAFIDAVML---VRLPYHLSALSQAAAIVALRHSADTLGTVEKLSVE 290 Query: 333 YINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWL 392 + + +ELG E + DFS + + + L++G L Sbjct: 291 RVR----VAARLEELGYAVVPSESNFVFFGDFS-----DQHAAWQAFLDRG-------VL 334 Query: 393 INELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKL 439 I ++G+ T + E ++DA+L+ A E +KL Sbjct: 335 IRDVGIAGHLRTTIGVPE--------------ENDAFLDAAAEIIKL 367 >3G0T-A nrPDB Length = 437 Score = 167 bits (423), Expect = 9e-42, Method: Composition-based stats. Identities = 68/371 (18%), Positives = 124/371 (33%), Gaps = 46/371 (12%) Query: 36 SLTNEAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRP 95 + + A N K G + + G PQ I+ + L + + Y G P Sbjct: 26 ASIRDLVALVTNLEKATGTKFCRMEMGVPGLPAPQIGIETEIQKLREGVASIYPNLDGLP 85 Query: 96 SLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMG----LLNAGDEVIVFEPFFDQ 151 L + N ++ A T G+ +G + N + +P F+ Sbjct: 86 ELKQEASRFAKLFVNIDIPARACVPTVGSMQGCFVSFLVANRTHKNREYGTLFIDPGFNL 145 Query: 152 YIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPI 211 + G K + D RGE+ E + + T + ++I + P+NP Sbjct: 146 NKLQCRILGQKF--------ESFDLFEYRGEKLREKLESYLQ--TGQFCSIIYSNPNNPT 195 Query: 212 GKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATL-----SPEIGQLTLTV 266 + T EEL +G + KH+V++I D Y + F ++ + Sbjct: 196 WQCMTDEELRIIGELATKHDVIVIEDLAYFGMDFRKDYSHPGEPLYQPSVANYTDNYILA 255 Query: 267 GSAGKSFAATGWRIGWVLSLNAELLSY----AAKAHTRICF--------------ASPSP 308 S+ K+F+ G RIG VL ++ +L ++ R+ F + Sbjct: 256 LSSSKAFSYAGQRIG-VLMISGKLYEREYPDLEESFGRLRFGEALSSSALYALSSGATHS 314 Query: 309 LQEACANSINDALKIGY-FEKMRQEYINKFKIFTSIFDELGLPYT-------APEGTYFV 360 Q A + Y F EY K +I +F + G ++ Sbjct: 315 AQWGMAAMLKACNDGEYNFRDSVIEYGRKARIMKKMFLDNGFNIVYDKDGNEPLADGFYF 374 Query: 361 LVDFSKVKIPE 371 V + + + Sbjct: 375 TVGYKGMDSSK 385 >1D2F-A nrPDB Length = 390 Score = 164 bits (415), Expect = 6e-41, Method: Composition-based stats. Identities = 67/388 (17%), Positives = 140/388 (36%), Gaps = 39/388 (10%) Query: 55 ELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELK 114 +L+ ++ I+ + L + YS + + ++ +S + T + Sbjct: 29 DLLPFTISDMDFATAPCIIEALNQRLMHGVF-GYSRWKND-EFLAAIAHWFSTQHYTAID 86 Query: 115 AENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKEL 174 ++ V + + G+ V++ P +D + IE G + +P+ K+ Sbjct: 87 SQTVVYGPSVIYMVSELIRQWSETGEGVVIHTPAYDAFYKAIE--GNQRTVMPVALEKQA 144 Query: 175 DQRNTRGEEWTIDFEQFEKAI-TSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVV 233 D W D + E + + K +++ +P NP GKV+T +EL + ++C +H V Sbjct: 145 DG-------WFCDMGKLEAVLAKPECKIMLLCSPQNPTGKVWTCDELEIMADLCERHGVR 197 Query: 234 IISDEVYEHLYFTDS-FTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELL- 291 +ISDE++ + + + + ++ L + S KSF + + N+ Sbjct: 198 VISDEIHMDMVWGEQPHIPWSNVARGDWAL---LTSGSKSFNIPALTGAYGIIENSSSRD 254 Query: 292 SYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDE--LGL 349 +Y + R +SPS L + + + +R + + L Sbjct: 255 AYLSALKGRDGLSSPSVLALTAHIAAYQQGAP-WLDALRIYLKDNLTYIADKMNAAFPEL 313 Query: 350 PYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIK 409 + P+ TY +D + I D + LI + V +P + + Sbjct: 314 NWQIPQSTYLAWLDLRPLNI--------------DDNALQKALIEQEKVAIMPGYTYGEE 359 Query: 410 EHEKAAENLLRFAVCKDDAYLENAVERL 437 +R + LE V L Sbjct: 360 -----GRGFVRLNAGCPRSKLEKGVAGL 382 >3FFH-A nrPDB Length = 363 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 64/290 (22%), Positives = 107/290 (36%), Gaps = 28/290 (9%) Query: 75 EAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMG 134 A +A Y SL + Y L+ E + T G +E I Sbjct: 51 AAIQANSSVETEIYPDGWAS-SLRKEVADFYQ------LEEEELIFTAGVDELIELLTRV 103 Query: 135 LLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKA 194 LL+ ++ P F QY N + G +V +P+ ++ D E A Sbjct: 104 LLDTTTNTVMATPTFVQYRQNALIEGAEVREIPLL------------QDGEHDLEGMLNA 151 Query: 195 ITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIAT 254 I KT V I P+NP G ++ + +V+++ DE Y Y T + Sbjct: 152 IDEKTTIVWICNPNNPTGNYIELADIQAFLDRV-PSDVLVVLDEAYIE-YVTPQPEKHEK 209 Query: 255 LSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACA 314 L L +T + K + R+G+ ++ + E++ R F + S Q+ Sbjct: 210 LVRTYKNLIIT-RTFSKIYGLASARVGYGIA-DKEIIRQL--NIVRPPFNTTSIGQKLAI 265 Query: 315 NSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDF 364 +I D IG I +++ F F+++ L P FVL+D Sbjct: 266 EAIKDQAFIGECRTSNANGIKQYEAFAKRFEKVKL---YPANGNFVLIDL 312 >3IF2-A nrPDB Length = 444 Score = 159 bits (401), Expect = 3e-39, Method: Composition-based stats. Identities = 67/390 (17%), Positives = 146/390 (37%), Gaps = 50/390 (12%) Query: 75 EAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLM- 133 +A + I M N YS +G + I++L+ ++ Y+ L +EN+ +T G+ Sbjct: 67 KANSSAIISMAN-YSNPQGDSAFIDALVGFFNRHYDWNLTSENIALTNGSQNAFFYLFNL 125 Query: 134 ---GLLNA----------GDEVIVF-EPFFDQYIPNIELCGGKVVYVPINPPKELDQRNT 179 +N +++ P + Y ++ + G V + + Sbjct: 126 FGGAFVNEHSQDKESKSVDKSILLPLTPEYIGY-SDVHVEGQHFAAVLPHIDEVTHDGEE 184 Query: 180 RGEEWTIDFEQFE---KAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIIS 236 ++ +DFE E + A+ + P NP G V T EE+ L I ++++ +I Sbjct: 185 GFFKYRVDFEALENLPALKEGRIGAICCSRPTNPTGNVLTDEEMAHLAEIAKRYDIPLII 244 Query: 237 DEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAK 296 D Y + F + A L+ + T+ S K G R G +++ +A+++ + Sbjct: 245 DNAY-GMPFPNIIYSDAHLNWD--NNTILCFSLSKI-GLPGMRTGIIVA-DAKVIEAVSA 299 Query: 297 AHTRICFASPSPLQEACANSINDALKIGYF--EKMRQEYINKFKIFTSIFDELG----LP 350 + + +P+ A A + +I +++ Y + + + + L Sbjct: 300 MNAVVNL-APTRFGAAIATPLVANDRIKQLSDNEIKPFYQKQATLAVKLLKQALGDYPLM 358 Query: 351 YTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFY--- 407 PEG F+ + F + I + + G + +P F+ Sbjct: 359 IHKPEGAIFLWLWFKDLPI---------------STLDLYERLKAKGTLIVPSEYFFPGV 403 Query: 408 IKEHEKAAENLLRFAVCKDDAYLENAVERL 437 + A +R ++ D+ L + ++ + Sbjct: 404 DVSDYQHAHECIRMSIAADEQTLIDGIKVI 433 >4R2N-A nrPDB Length = 367 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 71/381 (18%), Positives = 124/381 (32%), Gaps = 45/381 (11%) Query: 56 LINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKA 115 I L + P +A D VN+Y P G L +L + P + Sbjct: 25 AIKLASNETVFGPLPSVRAAIDRATD--TVNRY-PDNGCVQLKAALARHLGP----DFAP 77 Query: 116 ENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELD 175 E+V V G+ + + GDEV+ F+ Y P + + G + VP+ Sbjct: 78 EHVAVGCGSVSLCQQLVQVTASVGDEVVFGWRSFELYPPQVRVAGAIPIQVPLT------ 131 Query: 176 QRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVII 235 + T D +T +T+ + + P+NP V + L H ++I Sbjct: 132 -------DHTFDLYAMLATVTDRTRLIFVCNPNNPTSTVVGPDALARFVEAVPAH-ILIA 183 Query: 236 SDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAA 295 DE Y Y D + + + + K++ G RIG+ + + ++++ Sbjct: 184 IDEAYVE-YIRDGMRPDSLGLVRAHNNVVVLRTFSKAYGLAGLRIGYAIG-HPDVITALD 241 Query: 296 KAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPE 355 K + F S Q A S + + ++ G P Sbjct: 242 K--VYVPFTVSSIGQAAAIAS---LDAADELLARTDTVVAERARVSAELRAAGF-TLPPS 295 Query: 356 GTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAA 415 FV + ++ + + D RI GV + Sbjct: 296 QANFVWLPLGS--------RTQDFVEQAADARIVVRPYGTDGVRVT-------VAAPEEN 340 Query: 416 ENLLRFAVC-KDDAYLENAVE 435 + LRFA + D L A+E Sbjct: 341 DAFLRFARRWRSDQKLAAALE 361 >3G7Q-A nrPDB Length = 417 Score = 146 bits (368), Expect = 2e-35, Method: Composition-based stats. Identities = 70/414 (16%), Positives = 134/414 (32%), Gaps = 48/414 (11%) Query: 49 SKNQGRELINLGQGFFSYSPP--QFAIKEAQKALDIPMVNQ----YSPTRGRPSLINSLI 102 + G I LG G ++ P + ++ Y +G+ +L+N+L Sbjct: 28 LRTPG--AIMLGGGNPAHIPAMQDYFQTLLTDMVESGKAADALCNYDGPQGKTALLNALA 85 Query: 103 KLYSPIYNTELKAENVTVTTGANEGILSCLMGLLN---AGDEVIVFEPFFDQYIPNIELC 159 L +++ +N+ +T G+ G V P +YI + Sbjct: 86 VLLRETLGWDIEPQNIALTNGSQSAFFYLFNLFAGRRADGSTKKVLFPLAPEYIGYADSG 145 Query: 160 GGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREE 219 ++V P EL + +DFE I +T + ++ P NP G V T EE Sbjct: 146 LEDDLFVSARPNIELLPEGQFK--YHVDFEHLH--IGEETGMICVSRPTNPTGNVITDEE 201 Query: 220 LTTLGNICVKHNVVIISDEVYE----HLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAA 275 L L + +HN+ ++ D Y + F+++ P + S K Sbjct: 202 LMKLDRLANQHNIPLVIDNAYGVPFPGIIFSEAR-------PLWNPNIILCMSLSK-LGL 253 Query: 276 TGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYIN 335 G R G +++ + + + A C + L ++ Y Sbjct: 254 PGSRCGIIIANDKTITAIANMNGIISLAPGGMGPAMMCEMIKRNDLLRLSETVIKPFYYQ 313 Query: 336 KFK----IFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHW 391 + + I E PEG F+ + F + I + + Sbjct: 314 RVQQTIAIIRRYLSEERCLIHKPEGAIFLWLWFKDLPIT---------------TELLYQ 358 Query: 392 LINELGVVAIPPTEF--YIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLKDY 443 + GV+ +P F + + +R + +E V+ L + Sbjct: 359 RLKARGVLMVPGHYFFPGLDKPWPHTHQCMRMNYVPEPDKIEAGVKILAEEIER 412 >3LY1-A nrPDB Length = 354 Score = 145 bits (366), Expect = 4e-35, Method: Composition-based stats. Identities = 64/361 (17%), Positives = 129/361 (35%), Gaps = 57/361 (15%) Query: 70 QFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGIL 129 A A+ A+ N+Y+ L N L + ++A ++ +T G++EGI Sbjct: 32 PKAQAAARDAVV--KANRYAKNE-ILMLGNKLAAHHQ------VEAPSILLTAGSSEGIR 82 Query: 130 SCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFE 189 + + + ++++ E + ++ G KV V + + W D E Sbjct: 83 AAIEAYASLEAQLVIPELTYGDGEHFAKIAGMKVTKVKML------------DNWAFDIE 130 Query: 190 QFEKAIT--SKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTD 247 + A+ S V + P+NP G T ++ N + I DE Y Sbjct: 131 GLKAAVAAYSGPSIVYLVNPNNPTG-TITPADVIEPWIASKPANTMFIVDEAYAEFVNDP 189 Query: 248 SFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPS 307 F I+ + + + + + + K A G R+G+ ++ + +++ + Sbjct: 190 RFRSISPMITQGAENIILLKTFSKIHAMAGMRVGYAVA-HPTVIALMGRYVAGEKINFSG 248 Query: 308 PLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKV 367 +A S+ND+ I Y +K +I ++L LPY EG + F ++ Sbjct: 249 V--DAALASMNDSAFITYSKKSNDV---SRQILLKALEDLKLPYLPSEGNFV----FHQL 299 Query: 368 KIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDD 427 +P + + + GV+ F A+N R ++ Sbjct: 300 VVP---------------LKDYQTHMADAGVLI--GRAF------PPADNWCRISLGTPQ 336 Query: 428 A 428 Sbjct: 337 E 337 >1IJI-A nrPDB Length = 356 Score = 144 bits (363), Expect = 7e-35, Method: Composition-based stats. Identities = 55/288 (19%), Positives = 115/288 (39%), Gaps = 29/288 (10%) Query: 80 LDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAG 139 L +N+Y +P ++I+ Y+ +K E V V+ GA+EGI + G Sbjct: 47 LTQQTLNRYP--ECQP---KAVIENYAQYAG--VKPEQVLVSRGADEGIELLIRAFCEPG 99 Query: 140 -DEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSK 198 D ++ P + Y + E G + VP + W +D + + Sbjct: 100 KDAILYCPPTYGMYSVSAETIGVECRTVPTL------------DNWQLDLQGISDKLDG- 146 Query: 199 TKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPE 258 K V + +P+NP G++ ++ TL + + ++++DE Y S P Sbjct: 147 VKVVYVCSPNNPTGQLINPQDFRTLLEL-TRGKAIVVADEAYIEFCPQASLAGWLAEYPH 205 Query: 259 IGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSIN 318 + + + K+FA G R G+ L+ N E+++ K + +P+ + A +++ Sbjct: 206 LA----ILRTLSKAFALAGLRCGFTLA-NEEVINLLMKVIA--PYPLSTPVADIAAQALS 258 Query: 319 DALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSK 366 + E++ Q + + ++ + + T ++L F Sbjct: 259 PQGIVAMRERVAQIIAEREYLIAALKEIPCVEQVFDSETNYILARFKA 306 >1UU1-A nrPDB Length = 335 Score = 143 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 62/345 (17%), Positives = 127/345 (36%), Gaps = 41/345 (11%) Query: 40 EAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLIN 99 + AK A + + R+ L + P+ + E + L+ + Y + LI Sbjct: 5 DLIAKRAYPYETEKRDKTYLALNENPFPFPEDLVDEVFRRLNSDALRIYYDSP-DEELIE 63 Query: 100 SLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELC 159 ++ + L NV+V GA+E I ++ D + F P + Y + Sbjct: 64 KILSYLDTDF---LSKNNVSVGNGADEIIYVMMLMF----DRSVFFPPTYSCYRIFAKAV 116 Query: 160 GGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREE 219 G K + VP+ + + N + V I P+NP G VF REE Sbjct: 117 GAKFLEVPLTKDLRIPEVNVGEGD-----------------VVFIPNPNNPTGHVFEREE 159 Query: 220 LTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWR 279 + + K + DE Y + +S+ + + + + K+F+ R Sbjct: 160 IERIL----KTGAFVALDEAYYEFH-GESYVDFL----KKYENLAVIRTFSKAFSLAAQR 210 Query: 280 IGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKI 339 +G+V++ + +Y R+ F Q +++ FE+ + + + + Sbjct: 211 VGYVVASEKFIDAY---NRVRLPFNVSYVSQMFAKVALDH---REIFEERTKFIVEERER 264 Query: 340 FTSIFDELGLPYTAPEGTY-FVLVDFSKVKIPEDYPYPEEILNKG 383 S E+G T G + FV ++ + + ++ + + + Sbjct: 265 MKSALREMGYRITDSRGNFVFVFMEKEEKERLLEHLRTKNVAVRS 309 >2ZY3-A nrPDB Length = 546 Score = 142 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 77/398 (19%), Positives = 130/398 (32%), Gaps = 75/398 (18%) Query: 98 INSLIKLYSPIYNTELKAENVTVTTGANEGILSCL-----MGLLNAGDEVIVFEPFFDQY 152 +I+ ++ N+ G + GLL AGD+V + P F Y Sbjct: 149 RQYIIREMGA-DAIPSESVNLFAVEGGTAAMAYIFESLKLNGLLKAGDKVAIGMPVFTPY 207 Query: 153 IPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIG 212 I EL + V IN L+ W + +K K P NP Sbjct: 208 IEIPELAQYALEEVAINADPSLN--------WQYPDSELDKLKDPAIKIFFCVNPSNPPS 259 Query: 213 KVFTREELTTLGNICVKH--NVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAG 270 + L + NI +H +++I++D+VY F D F + + PE TL V S Sbjct: 260 VKMDQRSLERVRNIVAEHRPDLMILTDDVYG--TFADDFQSLFAICPE---NTLLVYSFS 314 Query: 271 KSFAATGWRIGWVLSLNAELLSYAAKAHT------------------------------- 299 K F ATGWR+G V + + A Sbjct: 315 KYFGATGWRLGVVAAHQQNVFDLALDKLQESEKVALDHRYRSLLPDVRSLKFIDRLVADS 374 Query: 300 -------RICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYT 352 ++P +Q A + + ++ ++ I + + + ELG+P Sbjct: 375 RAVALNHTAGLSTPQQVQMALFSLFALMDEADEYKHTLKQLIRRRETTL--YRELGMPPL 432 Query: 353 APEGT--YFVLVDFSKVKI---PEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFY 407 E Y+ L+D V E + + D + +E G+V +P F Sbjct: 433 RDENAVDYYTLIDLQDVTAKLYGEAFSEWAVKQSSTGDMLF--RIADETGIVLLPGRGFG 490 Query: 408 IKEHEKAAENLLRFAVCK-DDAYLENAVERLKLLKDYL 444 R ++ ++ L+ + D L Sbjct: 491 SNRPSG------RASLANLNEYEYAAIGRALRKMADEL 522 >2ZY2-A nrPDB Length = 544 Score = 138 bits (346), Expect = 7e-33, Method: Composition-based stats. Identities = 70/385 (18%), Positives = 128/385 (33%), Gaps = 74/385 (19%) Query: 111 TELKAENVTVTTGANEGILSCLM-----GLLNAGDEVIVFEPFFDQYIPNIELCGGKVVY 165 ++ ++ G + GLL AGD+V + P F YI EL + Sbjct: 160 VPPESVDLFAVEGGTAAMAYIFESLRISGLLKAGDKVAIGMPVFTPYIEIPELAQYDLKE 219 Query: 166 VPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGN 225 VPI+ + W + +K K P NP + L + Sbjct: 220 VPIHADPD--------NGWQYSDAELDKLKDPDVKIFFCVNPSNPPSVKMDQRSLDRVRA 271 Query: 226 ICVKH--NVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWV 283 I + +++I++D+VY F D F + ++ P + TL V S K F ATGWR+G + Sbjct: 272 IVAEQRPDLLILTDDVYG--TFADEFQSLFSVCP---RNTLLVYSFSKYFGATGWRLGVI 326 Query: 284 LSLNAELLSYA--------------------------------------AKAHTRICFAS 305 + + +A + ++ Sbjct: 327 AAHKDNVFDHALSQLPESAKKALDHRYRSLLPDVRSLKFIDRLVADSRVVALNHTAGLST 386 Query: 306 PSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYT-APEG-TYFVLVD 363 P +Q + + +++ ++ I + + + ELG+P P Y+ L+D Sbjct: 387 PQQVQMVLFSLFALMDEADAYKQALKQLIRRREATL--YRELGMPPLENPNSVNYYTLID 444 Query: 364 FSKVK---IPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLR 420 V E + + D + +E G+V +P F R Sbjct: 445 LQNVTCRLYGEAFSQWAVQQSSTGDMLF--RVADETGIVLLPGRGFGSDRPSG------R 496 Query: 421 FAVCK-DDAYLENAVERLKLLKDYL 444 ++ ++ L+ L D L Sbjct: 497 ASLANLNEYEYAAIGRALRRLADEL 521 >3FDD-A nrPDB Length = 533 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 75/398 (18%), Positives = 127/398 (31%), Gaps = 75/398 (18%) Query: 98 INSLIKLYSPIYNTELKAENVTVTTGANEGILSCL-----MGLLNAGDEVIVFEPFFDQY 152 +I+ ++ N+ G + GLL AGD+V + P F Y Sbjct: 149 RQYIIREMGA-DAIPSESVNLFAVEGGTAAMAYIFESMKVNGLLKAGDKVAIGMPVFTPY 207 Query: 153 IPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIG 212 I EL + V IN L+ W + +K K P NP Sbjct: 208 IEIPELAQYALEEVAINADPALN--------WQYPDSELDKLKDPAIKIFFCVNPSNPPS 259 Query: 213 KVFTREELTTLGNICVKH--NVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAG 270 L + I +H +++I++D+VY F D F + + P TL V S Sbjct: 260 VKMDERSLERVRKIVAEHRPDLMILTDDVYG--TFADGFQSLFAICP---ANTLLVYSFS 314 Query: 271 KSFAATGWRIGWVLSLNAELL--------------------------------------S 292 K F ATGWR+G V + + S Sbjct: 315 KYFGATGWRLGVVAAHKENIFDLALGRLPESEKTALDDRYRSLLPDVRSLKFLDRLVADS 374 Query: 293 YAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYT 352 A + ++P +Q + + ++ ++ I + + + ELG P Sbjct: 375 RAVALNHTAGLSTPQQVQMTLFSLFALMDESDQYKHTLKQLIRRREATL--YRELGTPPQ 432 Query: 353 APEGT--YFVLVDFSKVKI---PEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFY 407 E Y+ L+D V E + + D + +E G+V +P F Sbjct: 433 RDENAVDYYTLIDLQDVTSKLYGEAFSKWAVKQSSTGDMLF--RIADETGIVLLPGRGFG 490 Query: 408 IKEHEKAAENLLRFAVCK-DDAYLENAVERLKLLKDYL 444 R ++ ++ L+ + D L Sbjct: 491 SDRPSG------RASLANLNEYEYAAIGRALRQMADEL 522 >3F6T-A nrPDB Length = 533 Score = 132 bits (332), Expect = 3e-31, Method: Composition-based stats. Identities = 83/379 (21%), Positives = 132/379 (34%), Gaps = 71/379 (18%) Query: 117 NVTVTTGANEGILSCLMGL-----LNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPP 171 ++ T G I+ L L GD++ + EP F Y+ EL ++V V Sbjct: 166 DLFPTEGGTAAIVYAFHSLAENHLLKKGDKIAINEPIFTPYLRIPELKDYELVEV----- 220 Query: 172 KELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKH- 230 D + +W I+ + EK KA+I+ P NP K F L + K+ Sbjct: 221 ---DLHSYEKNDWEIEPNEIEKLKDPSIKALIVVNPTNPTSKEFDTNALNAIKQAVEKNP 277 Query: 231 NVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAEL 290 ++IISDEVY +F I ++ P T+ V S K F TGWR+G + + Sbjct: 278 KLMIISDEVYGAFV--PNFKSIYSVVP---YNTMLVYSYSKLFGCTGWRLGVIALNEKNV 332 Query: 291 ----LSYAAKAHTR--------------------------------ICFASPSPLQEACA 314 +++ K R +P Q A Sbjct: 333 FDDNIAHLDKVELRQLHKRYSSVVLDPDKMKFIDRLCADSRSIGLYHTAGLSTPQQIMEA 392 Query: 315 NSINDALKIGYFEKMRQEYIN-KFKIFTSIFDELGLPYTAPEGT------YFVLVDFSKV 367 L YI+ K+ + +D+L AP+ Y+ L+D ++ Sbjct: 393 LFSMTHLLTSTNGGSDDPYIDIARKLVSERYDQLHDAMQAPKDETDTNTHYYSLIDIYRL 452 Query: 368 KIPEDYPYPEEIL-NKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCK- 425 + L N + L + GVV + F K E LR + Sbjct: 453 AEKIYGKEFRDYLTNNFEQVDFLLKLAEKNGVVLVDGVGFGAKPGE------LRVSQANL 506 Query: 426 -DDAYLENAVERLKLLKDY 443 + Y + L+LLK+Y Sbjct: 507 PTEDYALIGKQVLELLKEY 525 >4RAE-A nrPDB Length = 394 Score = 131 bits (328), Expect = 8e-31, Method: Composition-based stats. Identities = 58/369 (15%), Positives = 125/369 (33%), Gaps = 43/369 (11%) Query: 57 INLGQGFFSYSPPQFAIKEAQKALDIPM--VNQYSPTRGRPSLINSLIKLYSPIYNTELK 114 + L + P + + + +++ +++Y P R +L L + +L Sbjct: 35 VRLNTNENPHPPTRALVDDVVRSVREAAIDLHRY-PDRDAVALRADLAGYLTAQTGIQLG 93 Query: 115 AENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKEL 174 EN+ G+NE + L G I F P + + I G ++ + + Sbjct: 94 VENIWAANGSNEILQQLLQAFGGPGRSAIGFVPSYSMHP--IISDGTHTEWIEASRANDF 151 Query: 175 DQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVI 234 + K V I +P+NP G+ + +L L ++ + Sbjct: 152 GLDVDVAVA---------AVVDRKPDVVFIASPNNPSGQSVSLPDLCKLLDVAPG---IA 199 Query: 235 ISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYA 294 I DE Y +L E + + K+FA G R+G++++ A + + Sbjct: 200 IVDEAYGEFSSQP---SAVSLVEEYPSKLVVTRTMSKAFAFAGGRLGYLIATPAVIDAML 256 Query: 295 AKAHTRICFASPSPLQEACANSI-NDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTA 353 R+ + S Q A ++ + + + E + T+ +++G Sbjct: 257 L---VRLPYHLSSVTQAAARAALRHSDDTLSSVAALIAE----RERVTTSLNDMGFRVIP 309 Query: 354 PEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEK 413 + + + +F+ + L G LI ++G+ P + Sbjct: 310 SDANFVLFGEFA-----DAPAAWRRYLEAGI-------LIRDVGI---PGYLRATTGLAE 354 Query: 414 AAENLLRFA 422 + LR + Sbjct: 355 ENDAFLRAS 363 >1AY8-A nrPDB Length = 394 Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats. Identities = 63/326 (19%), Positives = 113/326 (34%), Gaps = 42/326 (12%) Query: 47 NNSKNQGRELINLGQGFF----SYSPPQFAIKEA-QKALDIPMVNQYSPTRGRPSLINSL 101 QG+ I+LG G + ++P A+ A Q+ L+ Y+ G P ++ Sbjct: 21 RADPRQGK--IDLGVGVYKDATGHTPIMRAVHAAEQRMLETETTKTYAGLSGEPEFQKAM 78 Query: 102 IKLYSPIYNTELKAENV--TVTTGANEGILSCL--MGLLNAGDEVIVFEPFFDQYIPNIE 157 +L I LK+E T G + L + N V V +P + ++ + Sbjct: 79 GEL---ILGDGLKSETTATLATVGGTGALRQALELARMANPDLRVFVSDPTWPNHVSIMN 135 Query: 158 LCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVII---NTPHNPIGKV 214 G +P+ + D +DFE + + + K ++ HNP G Sbjct: 136 FMG-----LPVQTYRYFDAETR-----GVDFEGMKADLAAAKKGDMVLLHGCCHNPTGAN 185 Query: 215 FTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIAT---LSPEIGQLTLTVGSAGK 271 T ++ + +I K + + D Y+ F D A L L S K Sbjct: 186 LTLDQWAEIASILEKTGALPLIDLAYQG--FGDGLEEDAAGTRLIASRIPEVLIAASCSK 243 Query: 272 SFAATGWRIGWVLSLNA-----ELLSYAAKAHTRICFASPSPLQEACANSINDALKI--- 323 +F R G +L+L A EL A R ++ P +++ ++ Sbjct: 244 NFGIYRERTGCLLALCADAATRELAQGAMAFLNRQTYSFPPFHGAKIVSTVLTTPELRAD 303 Query: 324 --GYFEKMRQEYINKFKIFTSIFDEL 347 E +R + + +L Sbjct: 304 WMAELEAVRSGMLRLREQLAGELRDL 329 >3HDO-A nrPDB Length = 360 Score = 122 bits (305), Expect = 4e-28, Method: Composition-based stats. Identities = 54/306 (17%), Positives = 99/306 (32%), Gaps = 39/306 (12%) Query: 57 INLGQGFFSYSPPQFAIKEAQKAL--DIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELK 114 I L Y P +K + L D + Y P+ L +LY Sbjct: 29 IKLNTNENPYPPSPEVVKAILEELGPDGAALRIY-PSASSQKLREVAGELYG------FD 81 Query: 115 AENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKEL 174 + + G++E + + + G+E+ P + Y E+ G +V + + Sbjct: 82 PSWIIMANGSDEVLNNLIRAFAAEGEEIGYVHPSYSYYGTLAEVQGARVRTFGLTGDFRI 141 Query: 175 DQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVI 234 R E K + TP+ P+G F E + L C ++ Sbjct: 142 AGFPERYEG----------------KVFFLTTPNAPLGPSFPLEYIDELARRCAG---ML 182 Query: 235 ISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYA 294 + DE Y A + + + KS++ G RIG ++ E+++ Sbjct: 183 VLDETYAEFA-----ESNALELVRRHENVVVTRTLSKSYSLAGMRIGLAIA-RPEVIAAL 236 Query: 295 AKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAP 354 K + Q AC ++ D Y + + + FT+ +G Sbjct: 237 DKIRDH--YNLDRLAQAACVAALRDQ---AYLSECCRRIRETREWFTTELRSIGYDVIPS 291 Query: 355 EGTYFV 360 +G Y Sbjct: 292 QGNYLF 297 >3GET-A nrPDB Length = 365 Score = 118 bits (296), Expect = 4e-27, Method: Composition-based stats. Identities = 56/340 (16%), Positives = 126/340 (37%), Gaps = 34/340 (10%) Query: 54 RELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTEL 113 +E+I L + P AI+ ++ + + Y L ++L + Y + Sbjct: 30 KEVIKLASNENPFGTPPKAIECLRQ--NANKAHLYPDDSMI-ELKSTLAQKYK------V 80 Query: 114 KAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKE 173 + EN+ + G+++ I + LN+ + + F Y + CG K Sbjct: 81 QNENIIIGAGSDQVIEFAIHSKLNSKNAFLQAGVTFAMYEIYAKQCGAKC---------- 130 Query: 174 LDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVV 233 + +F++ + + K + + P+NP+G+ E T + + + Sbjct: 131 --YKTQSITHNLDEFKKLYETHKDEIKLIFLCLPNNPLGECLDASEATEFIKGVNE-DCL 187 Query: 234 IISDEVYEHLY-FTDSFTRI--ATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAEL 290 ++ D Y F DS + L E L +G+ K + G RIG+ ++ NA + Sbjct: 188 VVIDAAYNEFASFKDSKKHLEPCELIKEF-DNVLYLGTFSKLYGLGGLRIGYGIA-NANI 245 Query: 291 LSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLP 350 +S K R F + +A +++D + EK + ++ +++ + + Sbjct: 246 ISAFYKL--RAPFNVSNLALKAAVAAMDDD---EFTEKTLENNFSQMELYKEFAKKHNIK 300 Query: 351 YTAPEGTY--FVLVDFSKVKIPEDYPYPEEILNKGKDFRI 388 + + + + + E I+ K + + Sbjct: 301 IIDSYTNFITYFFDEKNSTDLSEKLLKKGIIIRNLKSYGL 340 >3EUC-A nrPDB Length = 367 Score = 114 bits (285), Expect = 7e-26, Method: Composition-based stats. Identities = 52/332 (15%), Positives = 101/332 (30%), Gaps = 33/332 (9%) Query: 54 RELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTEL 113 L+ L Y P E L +N+Y +L + Sbjct: 30 HGLVKLDAMENPYRLPPALRSELAARLGEVALNRYPVPS-----SEALRAKLKEVMQVPA 84 Query: 114 KAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKE 173 E V + G++E I + G +V+ P F Y + + G + V VP+ Sbjct: 85 GME-VLLGNGSDEIISMLALAAARPGAKVMAPVPGFVMYAMSAQFAGLEFVGVPLRA--- 140 Query: 174 LDQRNTRGEEWTIDFEQFEKAITSK-TKAVIINTPHNPIGKVFTREELTTLGNICVKH-- 230 ++T+D A+ V + P+NP G +F ++ + Sbjct: 141 ---------DFTLDRGAMLAAMAEHQPAIVYLAYPNNPTGNLFDAADMEAIVRAAQGSVC 191 Query: 231 NVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAEL 290 +++ DE Y+ +R+ L + + K G R+G+V + + Sbjct: 192 RSLVVVDEAYQPFAQESWMSRLTDFG-----NLLVMRTVSK-LGLAGIRLGYVAG-DPQW 244 Query: 291 LSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLP 350 L K R + + ++ + ++ + + G Sbjct: 245 LEQLDK--VRPPYNVNVLTEATALFALEH---VAVLDEQAAQLRAERSRVAEGMAAHGGV 299 Query: 351 YTAPEGTYFVLVDFSKVKIPEDYPYPEEILNK 382 P F+L D ++L K Sbjct: 300 TVFPSAANFLLARVPDAAQTFDRLLARKVLIK 331 >4WBT-A nrPDB Length = 376 Score = 113 bits (282), Expect = 2e-25, Method: Composition-based stats. Identities = 68/402 (16%), Positives = 133/402 (33%), Gaps = 58/402 (14%) Query: 45 AANNSKNQGRELI-NLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIK 103 + GR++ +G + P + ++A +Y+ L +L + Sbjct: 26 PEALERQHGRKIAARIGANESGFGPAPSVLLAIRQAA--GDTWKYADPENH-DLKQALAR 82 Query: 104 LYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKV 163 N+ + G + + + ++ AG V+ + + ++ GG++ Sbjct: 83 HLGT------SPANIAIGEGIDGLLGQIVRLVVEAGAPVVTSLGGYPTFNYHVAGHGGRL 136 Query: 164 VYVPINPPKELDQRNTRGEEWTIDFEQFEKAI-TSKTKAVIINTPHNPIGKVFTREELTT 222 V VP + D E A+ V + P NP+G + E + Sbjct: 137 VTVP-------------YADDREDLEGLLAAVGRENAPLVYLANPDNPMGSWWPAERVVA 183 Query: 223 LGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGW 282 + ++++ DE Y D+ I +L + + K++ G RIG+ Sbjct: 184 FAQALPETTLLVL-DEAYCETAPRDALPPIESLID--KPNVIRARTFSKAYGLAGARIGY 240 Query: 283 VLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTS 342 LS + A R F A ++ D Y +++ + N + Sbjct: 241 TLSTPG---TAQAFDKIRNHFGMSRIGVAAAIAALADQ---DYLKEVTLKIANSRQRIGR 294 Query: 343 IFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIP 402 I + GL P T FV VD +D Y I+++ L+++ G+ Sbjct: 295 IAADSGLAPL-PSATNFVAVDC-----GKDASYARAIVDR---------LMSDHGI---- 335 Query: 403 PTEFYIKEHEKAAENLLRFAVCKDDA-YLENAV--ERLKLLK 441 F +R + D L A E ++ L Sbjct: 336 ---FIRMPGVAPLNRCIRISTAPDAEMDLLAAALPEVIRSLA 374 >5DJ3-A nrPDB Length = 376 Score = 109 bits (271), Expect = 3e-24, Method: Composition-based stats. Identities = 56/336 (16%), Positives = 107/336 (31%), Gaps = 36/336 (10%) Query: 108 IYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVP 167 + + V ++ + L + D V + P FD + G +V V Sbjct: 74 QHGYPAEPGRVLSCYSSSVSMEILARSLSASVDRVALVHPTFDNIADLLRGNGLDLVPV- 132 Query: 168 INPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNIC 227 EE + + S V + TP+NP G+V E L L C Sbjct: 133 --------------EEDALHGADLSAELLSSVGCVFVTTPNNPTGRVLAEERLRRLAEQC 178 Query: 228 VKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLN 287 +H V+ D + + A L E G + + GK + + G ++ Sbjct: 179 AEHGTVLALDTSFRGFDAAAHYDHYAVLQ-EAGCRWVVIEDTGKLWPTLDLKAGLLVFS- 236 Query: 288 AELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDEL 347 E + + SPL A + G + ++ + + Sbjct: 237 -EDIGLPVEKIYSDILLGVSPLILALIREFSRDAADGGLADLHAFILHNRSVVRRALAGV 295 Query: 348 -GLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEF 406 G+ + PE E + G+ + V A+P +F Sbjct: 296 EGVSFPDPE----------------SRSSVERVAFAGRTGTEVWEELQRHHVFALPCRQF 339 Query: 407 YIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLKD 442 + E ++++R A+ + LE +V+ L+ + + Sbjct: 340 HWAEPS-DGDHMVRIALSRSTEPLEKSVQVLRTVLE 374 >3RQ1-A nrPDB Length = 418 Score = 108 bits (270), Expect = 4e-24, Method: Composition-based stats. Identities = 60/314 (19%), Positives = 108/314 (34%), Gaps = 35/314 (11%) Query: 73 IKEAQKALDIPMVNQYSPTRGRPSLINSLIK--LYSPIYNTELKAENVTVTTGANEGILS 130 +KE +L Y+P G P + + K + +++ T G GI Sbjct: 61 VKEEYLSLSDSEHVGYAPIAGIPDFLCAAEKECFGNFRPEGHIRS---IATAGGTGGIHH 117 Query: 131 CLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQ 190 + GDEV+ + ++ Y G +V + N E + + Sbjct: 118 LIHNYTEPGDEVLTADWYWGAYRVICSDTGRTLVTYSLFDEHN----NFNHEAFQNRVNE 173 Query: 191 FEKAITSKTKAVIINTP-HNPIGKVFTREELTTLGNICV------KHNVVIISDEVYEHL 243 T+ VI NTP +NP G ++ ++ N ++NV+I D Y L Sbjct: 174 LAAKQTNVV--VIFNTPGNNPTGYSIEDKDWDSILNFLKDLVAIGRNNVIIGIDVAY--L 229 Query: 244 YFTDSFTRIATLSPEIGQ-----LTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAH 298 ++ + + LT S K F G R+G ++ ++ + Sbjct: 230 DYSGEKDEVRAFFNKFSHLPKEILTCVCYSLSKGFTMYGQRVGAMIGISDDEEIADEFFE 289 Query: 299 TRICFASPS------PLQEACANSINDALKIGYFEKMRQEY----INKFKIFTSIFDELG 348 + + P AN + D K +E R Y ++ IF ++G Sbjct: 290 VNKSTSRATWSNICRPAMRTMANIVADPAKFKEYEAERNCYYQLIRDRADIFKQEAAQVG 349 Query: 349 LPYTAPEGTYFVLV 362 LP G +F+ + Sbjct: 350 LPMLPYRGGFFITI 363 >3FTB-A nrPDB Length = 361 Score = 106 bits (263), Expect = 2e-23, Method: Composition-based stats. Identities = 46/245 (18%), Positives = 92/245 (37%), Gaps = 26/245 (10%) Query: 118 VTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQR 177 + + GA+E I + +++++ P + +Y N + G VV+ ++ Sbjct: 81 IVLGNGASEIIELSISLF----EKILIIVPSYAEYEINAKKHGVSVVFSYLD-------- 128 Query: 178 NTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISD 237 E ID+E I +VII P+NP G + +E+ + + + II D Sbjct: 129 ----ENMCIDYEDIISKIDD-VDSVIIGNPNNPNGGLINKEKFIHVLKLAEEKKKTIIID 183 Query: 238 EVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKA 297 E + + FT + + + + K FA G R G+ ++ N E+ + Sbjct: 184 EAF--IEFTGDPSSSFVGEIKNYSCLFIIRAMTKFFAMPGIRFGYGITNNKEIAAKIKAK 241 Query: 298 HTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGL--PYTAPE 355 + + A N + D Y E+ + K F +++G +P Sbjct: 242 QNPWNINCFAEM--AAINCLKDT---NYIEESLLWIKKERKRFIEELNKIGFIKRVFSPH 296 Query: 356 GTYFV 360 + + Sbjct: 297 ANFVL 301 >1LC8-A nrPDB Length = 364 Score = 102 bits (253), Expect = 4e-22, Method: Composition-based stats. Identities = 52/316 (16%), Positives = 111/316 (35%), Gaps = 32/316 (10%) Query: 55 ELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELK 114 +L++ P + LD + +Y P L +L + + + Sbjct: 25 QLLDFSANINPLGMPVSVKRALIDNLDC--IERY-PDADYFHLHQALARHHQ------VP 75 Query: 115 AENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKEL 174 A + G E I + GL ++ P F +Y + G ++ + Sbjct: 76 ASWILAGNGETESIFTVASGL-KP-RRAMIVTPGFAEYGRALAQSGCEIRRWSLR----- 128 Query: 175 DQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVI 234 + W + + +A+T + + TP+NP G + R L + + C N+ + Sbjct: 129 -----EADGWQLT-DAILEALTPDLDCLFLCTPNNPTGLLPERPLLQAIADRCKSLNINL 182 Query: 235 ISDEVYEHLYF-TDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSY 293 I DE + F +P I + S K +A G R+G+++ N++ + Sbjct: 183 ILDEAFIDFIPHETGFIPALKDNPHIW----VLRSLTKFYAIPGLRLGYLV--NSDDAAM 236 Query: 294 AAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTA 353 A ++ ++ + A ++ D+ + + + F +L L Sbjct: 237 ARMRRQQMPWSVNALAALAGEVALQDS---AWQQATWHWLREEGARFYQALCQLPLLTVY 293 Query: 354 PEGTYFVLVDFSKVKI 369 P ++L+ + I Sbjct: 294 PGRANYLLLRCEREDI 309 >2X5F-A nrPDB Length = 430 Score = 99.1 bits (245), Expect = 4e-21, Method: Composition-based stats. Identities = 56/294 (19%), Positives = 108/294 (36%), Gaps = 35/294 (11%) Query: 73 IKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENV---TVTTGANEGIL 129 + L + Y+P +G L + + N EL +N+ VT G+ Sbjct: 69 LDAMFNDLTPDEIFPYAPPQGIEELRDLWQQKM-LRDNPELSIDNMSRPIVTNALTHGLS 127 Query: 130 SCLMGLLNAGDEVIVFEPFFDQYIPNIEL-CGGKVVYVPINPPKELDQRNTRGEEWTIDF 188 +N D +++ E + Y G + PI ++ Sbjct: 128 LVGDLFVNQDDTILLPEHNWGNYKLVFNTRNGANLQTYPI-----------FDKDGHYTT 176 Query: 189 EQFEKAITSKTK---AVIINTPHNPIGKVFTREE----LTTLGNICVK-HNVVIISDEVY 240 + +A+ S K +I+N P+NP G T +E + + + K V+ + D+ Y Sbjct: 177 DSLVEALQSYNKDKVIMILNYPNNPTGYTPTHKEVTTIVEAIKALANKGTKVIAVVDDAY 236 Query: 241 EHLYFTDSFT-RIATLSPEIGQLTLT---VGSAGKSFAATGWRIGWVLS-----LNAELL 291 L++ D +T + T + + + A K F A G+R+G++ E+L Sbjct: 237 YGLFYEDVYTQSLFTALTNLHSNAILPIRLDGATKEFFAWGFRVGFMTFGTSDQTTKEVL 296 Query: 292 SYAAKAHTRICF-ASPSPLQEACANSI-NDALKIGYFEKMRQEYINKFKIFTSI 343 K R + P P Q A + + N+ E+ Q ++++ + Sbjct: 297 EAKVKGLIRSNISSGPLPTQSAVKHVLKNNKQFDKEIEQNIQTLKERYEVTKEV 350 >5X03-B nrPDB Length = 365 Score = 98.7 bits (244), Expect = 4e-21, Method: Composition-based stats. Identities = 56/358 (15%), Positives = 119/358 (33%), Gaps = 48/358 (13%) Query: 89 SPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPF 148 S +G + ++ +L S + + E + + G + ++ L LL + EP Sbjct: 39 SHPQGIYEVRAAITRLISLTRGVKCRPEQMIIGAG-TQVLMQLLTELLPKEAVYAMEEPG 97 Query: 149 FDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPH 208 + + ++ G +V + ++ IT + V++ TP Sbjct: 98 YRRMYQLLKNAGKQVKTIMLDEKGMSI-----------------AEITRQQPDVLVTTPS 140 Query: 209 N--PIGKVFTREELTTLGNICVKH-NVVIISDEVYEHLYFT-DSFTRIATLSPEIGQLTL 264 + P G + L N + II D+ + DS + +L + Q + Sbjct: 141 HQFPSGTIMPVSRRIQLLNWAAEEPRRYIIEDDYDSEFTYDVDSIPALQSL--DRFQNVI 198 Query: 265 TVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIG 324 +G+ KS G RI +++ L +Y K S Q I Sbjct: 199 YMGTFSKSL-LPGLRISYMVLPPELLRAY--KQRGYDLQTCSSLTQLTLQEFIESGEYQK 255 Query: 325 YFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGK 384 + +KM+Q Y K + + + +FS + + + Sbjct: 256 HIKKMKQHYKEKRERLITALE----------------AEFSGEVTVKGANAGLHFVTEFD 299 Query: 385 DFRISHWLINEL---GVVAIPPTEFYIKEHE-KAAENLLRFAVCK-DDAYLENAVERL 437 R +++ + + F +KE++ + L + + ++ V+RL Sbjct: 300 TRRTEQDILSHAAGLQLEIFGMSRFNLKENKRQTGRPALIIGFARLKEEDIQEGVQRL 357 >4K2M-A nrPDB Length = 443 Score = 98.7 bits (244), Expect = 4e-21, Method: Composition-based stats. Identities = 44/196 (22%), Positives = 80/196 (40%), Gaps = 28/196 (14%) Query: 103 KLYSPIYNTELKAENVTVTTGANEGILSCLMGL-LNAGDEVIVFEPFFDQYIPNIELCGG 161 + + + +T L V T+ + I+ L+ L LN GDEVI+ F + GG Sbjct: 106 EQFEKVLSTYLHKRYVIATSSGTDAIMIGLLALGLNPGDEVIMPANSFSATENAVLASGG 165 Query: 162 KVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELT 221 +YV INP + + ID ++ E+AIT TK ++ P+ ++ Sbjct: 166 VPIYVDINP-----------QTFCIDPDKIEEAITPYTKFIL------PVHLYGKHSDMQ 208 Query: 222 TLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIG 281 + I ++ + +I D + + TD + +T + K+F G + G Sbjct: 209 HIRQIANRYKLKVIEDAC-QGIGLTD--------LGKYADITTLSFNPYKNFGVCG-KAG 258 Query: 282 WVLSLNAELLSYAAKA 297 + + N EL + Sbjct: 259 AIATDNEELAKKCIQF 274 >4N0B-A nrPDB Length = 479 Score = 97.6 bits (241), Expect = 1e-20, Method: Composition-based stats. Identities = 56/358 (15%), Positives = 119/358 (33%), Gaps = 48/358 (13%) Query: 89 SPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPF 148 S +G + ++ +L S + + E + + G + ++ L LL + EP Sbjct: 146 SHPQGIYEVRAAITRLISLTRGVKCRPEQMIIGAG-TQVLMQLLTELLPKEAVYAMEEPG 204 Query: 149 FDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPH 208 + + ++ G +V + ++ IT + V++ TP Sbjct: 205 YRRMYQLLKNAGKQVKTIMLDEKGMSI-----------------AEITRQQPDVLVTTPS 247 Query: 209 N--PIGKVFTREELTTLGNICVKH-NVVIISDEVYEHLYFT-DSFTRIATLSPEIGQLTL 264 + P G + L N + II D+ + DS + +L + Q + Sbjct: 248 HQFPSGTIMPVSRRIQLLNWAAEEPRRYIIEDDYDSEFTYDVDSIPALQSL--DRFQNVI 305 Query: 265 TVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIG 324 +G+ KS G RI +++ L +Y K S Q I Sbjct: 306 YMGTFSKSL-LPGLRISYMVLPPELLRAY--KQRGYDLQTCSSLTQLTLQEFIESGEYQK 362 Query: 325 YFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGK 384 + +KM+Q Y K + + + +FS + + + Sbjct: 363 HIKKMKQHYKEKRERLITALE----------------AEFSGEVTVKGANAGLHFVTEFD 406 Query: 385 DFRISHWLINEL---GVVAIPPTEFYIKEHE-KAAENLLRFAVCK-DDAYLENAVERL 437 R +++ + + F +KE++ + L + + ++ V+RL Sbjct: 407 TRRTEQDILSHAAGLQLEIFGMSRFNLKENKRQTGRPALIIGFARLKEEDIQEGVQRL 464 >4EMY-A nrPDB Length = 413 Score = 96.4 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 51/302 (16%), Positives = 96/302 (31%), Gaps = 42/302 (13%) Query: 88 YSPTRGRPSLINSLIKLYSPIYNTELKAE---NVTVTTGANEGILSCLMGLLNAGDEVIV 144 Y+P G +I Y K E + T G I S + L+ GD +I Sbjct: 75 YAPIEGEKDYRKIVIDTLFGPY----KPEGYISAIATPGGTGAIRSAIFSYLDEGDPLIC 130 Query: 145 FEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTK---- 200 + ++ Y E G +++ + + +++AI + Sbjct: 131 HDYYWAPYRKICEEFGRN-----------FKTFEFFTDDFAFNIDVYKEAIDEGIRDSDR 179 Query: 201 -AVIINTP-HNPIGKVFTREELTTLGNIC------VKHNVVIISDEVYEHL-YFTDSFTR 251 A +IN+P +NP G + EE + + +I D Y D + Sbjct: 180 IASLINSPGNNPTGYSLSDEEWDEVITFLKEKAEDKDKKITLIVDVAYLEFAGDGDQQRK 239 Query: 252 IATLSPEIGQL--TLTVGSAGKSFAATGWRIGWVLSL--NAELLSYAAKAHTRICFASPS 307 + + + S KS A G R G + + + E++ + + S Sbjct: 240 FFEKFSNLPRNLFVVVAFSMSKSHTAYGLRSGAAVGISSSKEIIEEFEASLAHSARCNWS 299 Query: 308 PLQEACANSI-------NDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFV 360 A N + N + +R ++ +F + E L G +F Sbjct: 300 NGTHAAQNILIELERAENKKIYEQELVDLRNMLKSRADVFVTAAKENKLTMIPYFGGFFT 359 Query: 361 LV 362 + Sbjct: 360 FI 361 >3FKD-A nrPDB Length = 350 Score = 95.3 bits (235), Expect = 5e-20, Method: Composition-based stats. Identities = 55/362 (15%), Positives = 111/362 (30%), Gaps = 66/362 (18%) Query: 70 QFAIKEAQKALDIPMVNQYS-PTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGI 128 K + L+ + Y P G L L K + + VT G Sbjct: 31 DHLEKHLVENLNC--IRHYPEPDAGT--LRQMLAKR------NSVDNNAILVTNGPTAAF 80 Query: 129 LSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDF 188 G ++ P F +Y + +V + P N DF Sbjct: 81 YQIAQAF--RGSRSLIAIPSFAEYEDACRMYEHEVCFYPSNEDI-----------GEADF 127 Query: 189 EQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKH-NVVIISDEVYEHLYFTD 247 + + P+NP G++ + T + + H + + D+ Y Sbjct: 128 SNMD--------FCWLCNPNNPDGRLL---QRTEILRLLNDHPDTTFVLDQSYVSFTTE- 175 Query: 248 SFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPS 307 I + + + V S ++ G RIG++++ N + + A T +A + Sbjct: 176 --EVIRPADIKGRKNLVMVYSFSHAYGIPGLRIGYIVA-NKDFMKRVAAFST--PWAVNA 230 Query: 308 PLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKV 367 EA + + + +R+ N T++ G+ T+F+L Sbjct: 231 LAIEAAKFILIHPAQ--FTLPIRKWQRNTVDFITALNRLDGVEVHPSGTTFFLL------ 282 Query: 368 KIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDD 427 L KG + +++ E ++ + F + E+ +R + Sbjct: 283 -----------RLKKGTAAELKKYMLEEYNMLIRDASNFRGLD-----ESYVRITTQRPA 326 Query: 428 AY 429 Sbjct: 327 QN 328 >4F5M-A nrPDB Length = 406 Score = 93.7 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 54/348 (15%), Positives = 106/348 (30%), Gaps = 41/348 (11%) Query: 47 NNSKNQGRELINLGQGFFSYSPPQ-FAIKEAQKA----LDIPMVNQYSPTRGRPSLINSL 101 + G+ INLG G + + + +KA L+ Y G P Sbjct: 31 RADERPGK--INLGIGVYKDETGKTPVLTSVKKAEQYLLENETTKNYLGIDGIPEFGRCT 88 Query: 102 IKLYSPIYNTELKAENV--TVTTGANEGILSCLMGLLNAGD--EVIVFEPFFDQYIPNIE 157 +L + + + T G + L V V P + + Sbjct: 89 QELLFGKGSALINDKRARTAQTPGGTGALRVAADFLAKNTSVKRVWVSNPSWPNHKSVFN 148 Query: 158 LCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVII---NTPHNPIGKV 214 G +V E T+DF+ ++ ++ HNP G Sbjct: 149 SAGLEVREYAY----------YDAENHTLDFDALINSLNEAQAGDVVLFHGCCHNPTGID 198 Query: 215 FTREELTTLGNICVKHNVVIISDEVYEHL--YFTDSFTRIATLSPEIGQLTLTVGSAGKS 272 T E+ TL + V+ + + D Y+ + + + +L + S K+ Sbjct: 199 PTLEQWQTLAQLSVEKGWLPLFDFAYQGFARGLEEDAEGLRAFAAMHKEL-IVASSYSKN 257 Query: 273 FAATGWRIGW--VLSLNAE--------LLSYAAKAHTRICFASPSPLQEACANSINDALK 322 F R+G +++ ++E + + ++ S + +N A+ Sbjct: 258 FGLYNERVGACTLVAADSETVDRAFSQMKAAIRANYSNPPAHGASVVATILSNDALRAIW 317 Query: 323 IGYFEKMRQEYINKFKIFTSIFDELG----LPYTAPEGTYFVLVDFSK 366 MRQ ++F + E G + + F +K Sbjct: 318 EQELTDMRQRIQRMRQLFVNTLQEKGANRDFSFIIKQNGMFSFSGLTK 365 >3FSL-A nrPDB Length = 397 Score = 93.7 bits (231), Expect = 2e-19, Method: Composition-based stats. Identities = 63/371 (16%), Positives = 122/371 (32%), Gaps = 38/371 (10%) Query: 47 NNSKNQGRELINLGQGFF---SYSPPQ-FAIKEAQKALDIP--MVNQYSPTRGRPSLINS 100 ++ + +NL G + PQ A+ EA+ L+ + Y P G ++ Sbjct: 19 RFKEDPRSDKVNLSIGLYYNEDGIIPQLQAVAEAEARLNAQPHGASLYLPMEGLNCYRHA 78 Query: 101 LIKLYSPIYNTELKAENV--TVTTGANEGILSCLMGLLN---AGDEVIVFEPFFDQYIPN 155 + L + LK + V T G + + L V V +P ++ ++ Sbjct: 79 IAPLLFGADHPVLKQQRVATIQTLGGSGAL-KVGADFLKRYFPESGVWVSDPTWENHVAI 137 Query: 156 IELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVF 215 G +V P T G + D K + + + ++ HNP G Sbjct: 138 FAGAGFEVSTYP------WYDEATNGVRFN-DLLATLKTLQAGSIVLLHPCCHNPTGADL 190 Query: 216 TREELTTLGNICVKHNVVIISDEVYEHLYFT---DSFTRIATLSPEIGQLTLTVGSAGKS 272 T ++ + I ++ D Y+ D++ A S + L S K Sbjct: 191 TNDQWDAVIEILKARELIPFLDIAYQGFGAGMEEDAYAIRAIASAGLP--ALVSNSFSKI 248 Query: 273 FAATGWRIGWVLSLNAELLSYAA-----KAHTRICFASPSPLQEACANSI--NDALKIGY 325 F+ G R+G + + + + KA R ++SP ++ ++ALK + Sbjct: 249 FSLYGERVGGLSVMCEDAEAAGRVLGQLKATVRRNYSSPPNFGAQVVAAVLNDEALKASW 308 Query: 326 ---FEKMRQEYINKFKIFTSIF----DELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEE 378 E+MR + + + E Y + F S ++ Sbjct: 309 LKEVEEMRTRILAMRQELVKVLSTEMPERNFDYLLNQRGMFSYTGLSAAQVDRLREEFGV 368 Query: 379 ILNKGKDFRIS 389 L ++ Sbjct: 369 YLIASGRMCVA 379 >5WT2-A nrPDB Length = 401 Score = 89.1 bits (219), Expect = 4e-18, Method: Composition-based stats. Identities = 48/192 (25%), Positives = 77/192 (40%), Gaps = 34/192 (17%) Query: 65 SYSPPQFAIKEAQKALDIPMVNQYSP--------TRGRPSLINSLIKLYSPIYNTELKAE 116 + + ++ +D + + Y T P++ +L KLY I ++ + Sbjct: 8 DNNATTRIDPKVKEIMDPFLRDHYGNPSSLHQFGTETHPAIAEALDKLYKGINARDI--D 65 Query: 117 NVTVTTGANEGILSCLMGL-----LNAGDEVIV----FEPFFDQYIPNIELCGGKVVYVP 167 +V +T+ A E L G+ L G IV P +E G +V Y+P Sbjct: 66 DVIITSCATESNNWVLKGVYFDECLKKGKNHIVTTVAEHPAVRSTCNFLESLGVEVTYLP 125 Query: 168 INPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNIC 227 IN E +I EQ +AIT KT V + +N G +F EE +G IC Sbjct: 126 IN------------EHGSITAEQVREAITEKTALVSVMWANNETGLIFPIEE---IGAIC 170 Query: 228 VKHNVVIISDEV 239 + V+ +D V Sbjct: 171 KEKGVLFHTDAV 182 >3P1T-A nrPDB Length = 337 Score = 87.9 bits (216), Expect = 8e-18, Method: Composition-based stats. Identities = 56/360 (15%), Positives = 112/360 (31%), Gaps = 70/360 (19%) Query: 84 MVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVI 143 +N+Y P P ++ L + + +N+ + G +E + + Sbjct: 44 RINRY-PFDAEPRVMRKLAEHF------SCPEDNLMLVRGIDECFDRISAEFSSM--RFV 94 Query: 144 VFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVI 203 P FD Y I + G + + + LD + A S+ V+ Sbjct: 95 TAWPGFDGYRARIAVSGLRHFEIGLTDDLLLDPNDL--------------AQVSRDDCVV 140 Query: 204 INTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLT 263 + P NP G+ + EL L K ++ DE Y ++ G+ Sbjct: 141 LANPSNPTGQALSAGELDQLRQRAGK----LLIDETYVD------YSSFRARGLAYGENE 190 Query: 264 LTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKI 323 L S KS+ G R+G + + + A K C L A ND + Sbjct: 191 LVFRSFSKSYGLAGLRLGALFGPSELI--AAMKRKQWFCNVGTLDLHALEAALDNDRARE 248 Query: 324 GYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKG 383 + K + + + LG + E + ++ + + + Sbjct: 249 AHIAKT----LAQRRRVADALRGLGYRVASSEANFVLVENAAGERT-------------- 290 Query: 384 KDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLKDY 443 + E G+ +F + + +R ++ +++ L L +Y Sbjct: 291 ------LRFLRERGIQVKDAGQFGLH-------HHIRISIGREEDN----DRLLAALAEY 333 >3PD6-B nrPDB Length = 401 Score = 84.1 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 47/321 (14%), Positives = 93/321 (28%), Gaps = 29/321 (9%) Query: 50 KNQGRELINLGQGFF--SYSPP---QFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKL 104 ++ + +NLG G + P K + + +Y P G + +L Sbjct: 24 RDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAEL 83 Query: 105 YSPIYNTELKAEN--VTVTTGANEGI---LSCLMGLLNAGDEVIVFEPFFDQYIPNIELC 159 N LK+ T + S L +V + +P + + P Sbjct: 84 ALGENNEVLKSGRFVTVQTISGTGALRVGASFLQRFFKFSRDVFLPKPSWGNHTPIFRDA 143 Query: 160 GGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREE 219 G + + + D + G +++ E K I ++ ++ HNP G E+ Sbjct: 144 GMQ-----LQGYRYYDPKTC-GFDFSGALEDISK-IPEQSVLLLHACAHNPTGVDPRPEQ 196 Query: 220 LTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATL--SPEIGQLTLTVGSAGKSFAATG 277 + ++ K N+ D Y+ D + E G S K+ G Sbjct: 197 WKEIASVVKKKNLFAFFDMAYQGFASGDGDKDAWAVRHFIEQGINVCLCQSYAKNMGLYG 256 Query: 278 WRIGWVLSLNAE----------LLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFE 327 R+G + + L ++ + + + Sbjct: 257 ERVGAFTVVCKDAEEAKRVESQLKILIRPLYSNPPLNGARIAATILTSPDLRKQWLQEVK 316 Query: 328 KMRQEYINKFKIFTSIFDELG 348 M I+ S + G Sbjct: 317 GMADRIISMRTQLVSNLKKEG 337 >4WD2-A nrPDB Length = 408 Score = 84.1 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 47/312 (15%), Positives = 100/312 (32%), Gaps = 40/312 (12%) Query: 57 INLGQGFF----SYSPPQFAIKEAQKALDIPMVNQ-YSPTRGRPSLINSLIKLYSPIYNT 111 +NL G + P A++EA+ AL + Y P G + +++ L + Sbjct: 37 VNLSIGIYFDAEGRIPVMGAVREAETALQRDSGPKPYLPMVGLAAYRDAVQSLVFGADHP 96 Query: 112 ELKAENV--TVTTGANEGILSCLMGLLN---AGDEVIVFEPFFDQYIPNIELCGGKVVYV 166 A + T G + + L +V + +P ++ + E G V Sbjct: 97 ARAAGRIATLQTLGGSGAL-KVGADFLKRYFPDSQVWLSDPSWENHRFIFERAGFTVNTY 155 Query: 167 PINPPKELDQRNTRGEEWTIDFEQFEKAITS---KTKAVIINTPHNPIGKVFTREELTTL 223 P + F+ AI + ++ ++ HNP G + L Sbjct: 156 PY----------YDEATGGLKFDAMLAAIDALPARSIVLLHACCHNPTGVDLDEGQWEKL 205 Query: 224 GNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQL---TLTVGSAGKSFAATGWRI 280 ++ ++ D Y+ F A E+ + TL S K+F+ G R+ Sbjct: 206 IDVIEARELLPFVDMAYQG--FGAGLDADAFAVRELARRGVPTLVANSFSKNFSLYGERV 263 Query: 281 GWVLSLNAELLSYAAKAHT-----RICFASPSPLQEACANSINDALKIGYFEKMRQEYIN 335 G + + + + R +++P ++ +R+++ Sbjct: 264 GGLSVVCEDAAAAERVLGQLAGAVRSNYSNPQTYGAKVVAAVLGTP------ALRKQWEE 317 Query: 336 KFKIFTSIFDEL 347 + + Sbjct: 318 ELSAMCRRIARM 329 >5IWQ-A nrPDB Length = 434 Score = 83.7 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 73/432 (16%), Positives = 129/432 (29%), Gaps = 76/432 (17%) Query: 40 EAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQ-------KALDIPMVNQYSPTR 92 E + + K++ +L +L +G S FA + KA D V Y Sbjct: 19 EDIKRKFDELKSKNLKL-DLTRGKPSSEQLDFADELLALPGKGDFKAADGTDVRNYGGLD 77 Query: 93 GRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMG---LLNAGDEV------- 142 G + L + E V ++ I+ ++ + D V Sbjct: 78 GIVDIRQIWADLLG------VPVEQVLAGDASSLNIMFDVISWSYIFGNNDSVQPWSKEE 131 Query: 143 ----IVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAIT-S 197 I P +D++ E G +++ VP+N D + E+ + Sbjct: 132 TVKWICPVPGYDRHFSITERFGFEMISVPMNEDG-------------PDMDAVEELVKNP 178 Query: 198 KTKAV-IINTPHNPIGKVFTREELTTLGNI-CVKHNVVIISDEVYEHLYFTDSFTRIATL 255 + K + ++ NP G T + L + + ++ D Y TD F + + Sbjct: 179 QVKGMWVVPVFSNPTGFTVTEDVAKRLSAMETAAPDFRVVWDNAYAVHTLTDEFPEVIDI 238 Query: 256 -----SPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQ 310 + S K G + + L +AE + Q Sbjct: 239 VGLGEAAGNPNRFWAFTSTSKI-TLAGAGVSFFL-TSAENRKWYTGHAGIRGIGPNKVNQ 296 Query: 311 EACANSINDALKIGYF-----EKMRQEYINKFKIFTSIFDELGLP-YTAPEGTYFVLVDF 364 A A DA + + ++ +I S E G+ +T P G YF+ +D Sbjct: 297 LAHARYFGDAEGVRAVMRKHAASLAPKFNKVLEILDSRLAEYGVAQWTVPAGGYFISLDV 356 Query: 365 SKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVC 424 +P E L E G+ + LR A Sbjct: 357 ----VPGTASRVAE-------------LAKEAGIALT-GAGSSYPLRQDPENKNLRLAPS 398 Query: 425 K-DDAYLENAVE 435 LE A++ Sbjct: 399 LPPVEELEVAMD 410 >3UWC-A nrPDB Length = 374 Score = 79.5 bits (194), Expect = 3e-15, Method: Composition-based stats. Identities = 38/143 (26%), Positives = 52/143 (36%), Gaps = 18/143 (12%) Query: 97 LINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNI 156 L L K + V TG + +S M + AGDEVI F + I Sbjct: 36 LGAELEKFEKRFAALHNAPHAIGVGTGTDALAMSFKMLNIGAGDEVITCANTFIASVGAI 95 Query: 157 ELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFT 216 G V V + ID E+ E AIT KTKA++ P+ Sbjct: 96 VQAGATPVLVD------------SENGYVIDPEKIEAAITDKTKAIM------PVHYTGN 137 Query: 217 REELTTLGNICVKHNVVIISDEV 239 ++ L I KHN+ I+ D Sbjct: 138 IADMPALAKIAKKHNLHIVEDAC 160 >6C3C-A nrPDB Length = 413 Score = 79.1 bits (193), Expect = 3e-15, Method: Composition-based stats. Identities = 65/415 (15%), Positives = 126/415 (30%), Gaps = 52/415 (12%) Query: 50 KNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQ----------YSPTRGRPSLIN 99 G L++L Q ++ + +A Q Y G + Sbjct: 27 PAPGAPLLDLTQHEIQALTMKYNLADAHTHQRQSASQQSIVSRLPQLWYEAEEGLQATYE 86 Query: 100 SLIKLYSPIYNTELKAENVT-----VTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIP 154 + + + + ++ A+ + M L V + EP FD Sbjct: 87 K--RFTEAFFQLHRQPTALVKNKTMLSYAASISTMVAGMFLKKERLAVTLIEPCFDNLYD 144 Query: 155 NIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKV 214 L V PI+ D E E+ + +T A+ + P+NP G Sbjct: 145 V--LANMDVPLYPIDESVFYDVDRIYPE--------LERRV--RTDALFLVDPNNPTGFS 192 Query: 215 F---TREELTTLGNICVKHNVVIISDEVYEHLY-FTDSFTR--IATLSPEIGQLTLTVGS 268 R+ + C H+ +++ D + F R + L G L + Sbjct: 193 LLRHGRKGFEEVVRFCKDHDKLLLIDFCFASFTLFEPELARFDMYELLENSGVRYLAIED 252 Query: 269 AGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEK 328 GK++ + + + + ++ HT + + + D+ Sbjct: 253 TGKTWPVQDAKCALITASD-DIWETVYNLHTSVLLNVSPFVLNMLTQYVRDSAADR-LAS 310 Query: 329 MRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRI 388 +R+ + D L Y P +V S D+P Sbjct: 311 VREVLTRNRECARKTLDGSILEYQEP------VVKVSVAWFRVDHPELTAT--------D 356 Query: 389 SHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLKDY 443 H L++ GV +P FY E K + +R A+ ++ +A+ + + D Sbjct: 357 VHRLLSADGVYVLPGRYFYWSEPSK-GDAYVRMALAREPEMFADAMALTRQVLDR 410 >6EZL-A nrPDB Length = 404 Score = 78.7 bits (192), Expect = 5e-15, Method: Composition-based stats. Identities = 56/375 (14%), Positives = 115/375 (30%), Gaps = 49/375 (13%) Query: 40 EAAAKAANNSKNQGRELINLGQGFF----SYSPPQFAI-KEAQKALDIPMVNQYSPTRGR 94 AK A K +L G + + P + K Q+ L++ +Y P G Sbjct: 22 SLVAKKAPEPKA------DLIIGAYRDAEGHPYPLNVVRKAEQRLLEMNADKEYLPMSGY 75 Query: 95 PSLINSLIKLYSPIYNTELKAENV-----TVTTGANEGILSCLMGLLNAGDEVIVFEPFF 149 I + Y + ENV TG+ L +L+ V + +P + Sbjct: 76 APFIE---ESLKIAYGDSVARENVVGIQGLSGTGSLSIGACFLARVLSRDTPVYISDPTW 132 Query: 150 DQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIIN---T 206 + + N R + IDF+ + + + I+ Sbjct: 133 PNHYAVMAAA---------NLTDLRKYRYYDNAKRCIDFDGLLEDLNGAPEGSIVILHAC 183 Query: 207 PHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLY---FTDSFTRIATLSPEIGQLT 263 HNP G T E+ + + ++ D Y+ + I + + ++ Sbjct: 184 AHNPTGMDPTHEQWAKILEVFQARRLIPFFDSAYQGYATGSLDNDAYSIRLFARQGMEM- 242 Query: 264 LTVGSAGKSFAATGWRIGW--VLSLNAE---LLSYAAKAHTRICFASPSPLQEACANSIN 318 L S K+ R+G +++ N + L+ + R +++P A + Sbjct: 243 LLAQSYSKNMGLYAERVGVCSIVTANPKKAPLIKSQLETIVRSQYSTPPAHGARVAYLVL 302 Query: 319 DALKI-----GYFEKMRQEYINKFKIFTSIFDELG----LPYTAPEGTYFVLVDFSKVKI 369 ++ M + + LG + + F + +K + Sbjct: 303 SDPELRAGWEQELRVMSTRVLEMRQALYDGLKRLGTPGSWEHIIQQVGMFSYLGLTKAQC 362 Query: 370 PEDYPYPEEILNKGK 384 + +L G+ Sbjct: 363 EKLIERRVFVLPSGR 377 >3BWN-A nrPDB Length = 391 Score = 78.3 bits (191), Expect = 6e-15, Method: Composition-based stats. Identities = 55/363 (15%), Positives = 103/363 (28%), Gaps = 63/363 (17%) Query: 94 RPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDE----VIVFEPFF 149 P L +++ L+ + N + + V TG+ + + + L + V+ PF+ Sbjct: 70 EPELEDAIKDLHGVVGNAATEDRYIVVGTGSTQLCQAAVHALSSLARSQPVSVVAAAPFY 129 Query: 150 DQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHN 209 Y V G+ W D ++ +P+N Sbjct: 130 STY-------------VEETTYVRSGMYKWEGDAWGFD--------KKGPYIELVTSPNN 168 Query: 210 PIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSA 269 P G + T+ N +I D Y ++T + + + Sbjct: 169 PDGTI-----RETVVNRPDDDEAKVIHDFAYYWPHYTP--------ITRRQDHDIMLFTF 215 Query: 270 GKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSIN--------DAL 321 K G RIGW L + E+ + Q A +N ++ Sbjct: 216 SKITGHAGSRIGWALVKDKEVAKKMVEYIIVNSIGVSKESQVRTAKILNVLKETCKSESE 275 Query: 322 KIGYFEKMRQEYI---NKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEE 378 +F+ R+ K + D LP PE F YP Sbjct: 276 SENFFKYGREMMKNRWEKLREVVKESDAFTLP-KYPEA-------FCNYFGKSLESYPAF 327 Query: 379 ILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLK 438 K+ + V++ + +R ++ + +ERL Sbjct: 328 AWLGTKEETDLVSELRRHKVMSRAGERCGSDK------KHVRVSMLSREDVFNVFLERLA 381 Query: 439 LLK 441 +K Sbjct: 382 NMK 384 >4WB0-B nrPDB Length = 414 Score = 77.9 bits (190), Expect = 8e-15, Method: Composition-based stats. Identities = 51/353 (14%), Positives = 109/353 (30%), Gaps = 45/353 (12%) Query: 45 AANNSKNQGRELINLGQG----FFSYSPPQFAIKEAQKAL-DIPMVNQYSPTRGRPSLIN 99 A + +G + NL G P +++A++ L D+ + +Y P G I+ Sbjct: 30 AKRAAAAKGPKA-NLVIGAYRDEQGLPYPLRVVRKAEQLLLDMNLNYEYLPISGYQPFID 88 Query: 100 SLIKLYSPIYNTELKAENVTV--TTGANEGILSCLMGLLNAGD----EVIVFEPFFDQYI 153 + Y ++ EN+ T + L + D + + +P + + Sbjct: 89 EAV---KMTYGDTVELENLVAVQTLSGTGALSLGAKLLTHVFDAEKTPIYLADPTWPNHY 145 Query: 154 PNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIIN---TPHNP 210 ++ G K + + +DFE +K I + + HNP Sbjct: 146 SIVKAAGWKDIR---------TYAYYDHKTLGLDFEGMKKDILAAPDGSVFLLHQCAHNP 196 Query: 211 IGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTV---G 267 G ++E+ + ++ + + + D Y+ Y + S A + + + V Sbjct: 197 TGVDPSQEQWNEIASLMLAKHHQVFFDSAYQG-YASGSLDTDAYAARLFARRGIEVLLAQ 255 Query: 268 SAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICF------ASPSPLQEACANSINDAL 321 S K+ R G + L + A P+ +++ Sbjct: 256 SFSKNMGLYSERAGTLSLLLKDKTKRADVKSVMDSLIRAEYTCPPAHGARLAHLILSNNE 315 Query: 322 KIGYFEKMRQEYINKFKIFTSIFDELGLPYTAP--------EGTYFVLVDFSK 366 +E + + + L P + F + SK Sbjct: 316 LRKEWEAELSAMAERIRTMRRTVYDELLRLQTPGRWEHVINQIGMFSFLGLSK 368 >4RKC-A nrPDB Length = 398 Score = 77.9 bits (190), Expect = 8e-15, Method: Composition-based stats. Identities = 51/337 (15%), Positives = 99/337 (29%), Gaps = 33/337 (9%) Query: 53 GRELINLGQGFF-SYSPPQFAIK----EAQKALDIPMVNQYSPTRGRPSLINSLIKLYSP 107 + +NLG G + S + Q+ D Y P G P +L Sbjct: 25 NPDKVNLGIGIYYDESGVMPVLDCVKIAEQRIADPISPRPYLPMAGLPGHRKGCQELLFG 84 Query: 108 IYNTELKAENV--TVTTGANEGILSCLMGLLN---AGDEVIVFEPFFDQYIPNIELCGGK 162 LK V T G + + ++ + V +P + +I E C + Sbjct: 85 KDAPVLKDGLVATIATIGGSGAL-KVGAEFIHEWFPQSKCYVSDPTWGNHIAIFEGCDIE 143 Query: 163 VVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTT 222 V P + + + + ++ HNP G TRE+ T Sbjct: 144 VGKYPYYDTATGGIKFDEMIAFFETLNKDDV-------LLLHPCCHNPTGVDLTREQWDT 196 Query: 223 LGNICVKHNVVIISDEVYEHLYFT-DSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIG 281 + N+ + ++ D Y+ DS + ++G S K+ + G R+G Sbjct: 197 VLNVIQERELIPFMDIAYQGFGEDMDSDAYAIRKAVDMGLPLFVSNSFSKNLSLYGERVG 256 Query: 282 WVLSLNA----------ELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQ 331 + + +L S + ++ + ++ +G MR Sbjct: 257 GLSVVCPTVDETERVFGQLNSTVRRIYSSPPSHGGRVVDIVMNDAALHEQWVGEVYAMRD 316 Query: 332 EYINKFKIFTSIFDEL----GLPYTAPEGTYFVLVDF 364 + S+ + Y + F Sbjct: 317 RIKSMRTKLKSVLEAKISGRNFDYLTAQNGMFSFTGL 353 >4W5K-A nrPDB Length = 396 Score = 77.5 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 44/308 (14%), Positives = 88/308 (28%), Gaps = 24/308 (7%) Query: 52 QGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNT 111 + +NL G + Q + E K + Y+P G S + KL Sbjct: 26 PAKRKVNLSIGVYRDDADQPFVLECVKQATLGTNMDYAPVTGIASFVEEAQKLCFGPTCA 85 Query: 112 ELKAENV--TVTTGANEGILS---CLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYV 166 L+ + T G + L + + + + + + G ++ Sbjct: 86 ALRDGRIASCQTLGGTGALRIGGDLLNRFVANCNRIYGPDVGYPNHESIFAKAGMELTPY 145 Query: 167 PINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNI 226 T+G E +KA V HNP G T ++ + ++ Sbjct: 146 ------SYYDPATKGLNLAGMLECLDKAPEGSVILVHAC-AHNPTGVDPTHDDWRQVCDV 198 Query: 227 CVKHNVVIISDEVYEHLYFTDSFTRIATLSP----EIGQLTLTVGSAGKSFAATGWRIGW 282 + N + D Y+ F P ++ + S +F G R G Sbjct: 199 IKRRNHIPFVDMAYQG--FATGQLDYDAFVPRHLVDMVPNLIVAQSFSANFGLYGHRCGA 256 Query: 283 VLSLN------AELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINK 336 + L+S A + P ++ + D ++K ++ ++ Sbjct: 257 LHISTASAEEAKRLVSQLALLIRPMYSNPPLYGAWVVSSILKDPQLTALWKKELKQMSSR 316 Query: 337 FKIFTSIF 344 Sbjct: 317 IAEVRKRL 324 >4EFF-A nrPDB Length = 420 Score = 76.4 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 49/340 (14%), Positives = 102/340 (30%), Gaps = 37/340 (10%) Query: 57 INLGQGFF---SYSPP--QFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNT 111 +NLG G + P + + ++ + Y P G + S+ KL + Sbjct: 52 VNLGVGVYTNEDGKIPLLRAVRDAEKARVEAGLPRGYLPIDGIAAYDASVQKLLLGDDSP 111 Query: 112 ELKAENVTVT--TGANEGILSC--LMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVP 167 + A V G + + LN +V + +P ++ + ++ G +VV P Sbjct: 112 LIAAGRVVTAQALGGTGALKIGADFLRTLNPKAKVAISDPSWENHRALFDMAGFEVVAYP 171 Query: 168 INPPKELDQRNTRGEEWTIDFEQFEKAIT---SKTKAVIINTPHNPIGKVFTREELTTLG 224 + ++F+ A+ T V+ HNP G + + Sbjct: 172 Y----------YDAKTNGVNFDGMLAALNGYEPGTIVVLHACCHNPTGVDLNDAQWAQVV 221 Query: 225 NICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQ-LTLTVGSAGKSFAATGWRIGWV 283 + +V D Y+ + A S KSF+ G R+G + Sbjct: 222 EVVKARRLVPFLDIAYQGFGESIEADAAAVRLFAAANLNVFVSSSFSKSFSLYGERVGAL 281 Query: 284 LSLNAELLSYAAKAHT-----RICFASPSPLQEACANSINDALKI-----GYFEKMRQEY 333 + A R +++P A ++ + ++ +MR Sbjct: 282 SIITDSKDEAARVLSQLKRVIRTNYSNPPTHGGAIVAAVLASPELRASWVQELGEMRDRI 341 Query: 334 INKFKIFTSIFDELGL----PYTAPEGTYFVLVDFSKVKI 369 G+ + + F + ++ Sbjct: 342 RAMRNGLVERLKAAGIERDFSFINAQRGMFSYSGLTSAQV 381 >3NYS-A nrPDB Length = 367 Score = 76.0 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 54/279 (19%), Positives = 86/279 (30%), Gaps = 38/279 (13%) Query: 86 NQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGL-LNAGDEVIV 144 QY L + L Y + + M L + GDEVI Sbjct: 29 GQYILGPEVTELEDRLADFVGAKY--------CISCANGTDALQIVQMALGVGPGDEVIT 80 Query: 145 FEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVII 204 + + L G K VYV I+P + +D + E AIT +TKA+I Sbjct: 81 PGFTYVATAETVALLGAKPVYVDIDP-----------RTYNLDPQLLEAAITPRTKAII- 128 Query: 205 NTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTL 264 P+ + + I K+ + +I D + + R LS T+ Sbjct: 129 -----PVSLYGQCADFDAINAIASKYGIPVIEDAA-QSFGASYKGKRSCNLS------TV 176 Query: 265 TVGSA--GKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALK 322 S G G + N + L+ A + R NS D L+ Sbjct: 177 ACTSFFPSAPLGCYG--DGGAIFTNDDELATAIRQIARHGQDRRYHHIRVGVNSRLDTLQ 234 Query: 323 IGYFEKMRQEYINKFKIFTSIFDELGLPYT-APEGTYFV 360 + + + + + E L GT F+ Sbjct: 235 AAILLPKLEIFEEEIALRQKVAAEYDLSLKQVGIGTPFI 273 >2CST-A nrPDB Length = 411 Score = 75.6 bits (184), Expect = 4e-14, Method: Composition-based stats. Identities = 54/346 (15%), Positives = 103/346 (29%), Gaps = 44/346 (12%) Query: 34 VWSLTNEAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRG 93 V+ LT + + N G +G P +++ A D + ++Y P G Sbjct: 16 VFKLTADFREDGDSRKVNLGVGAYRTDEGQPWVLPVVRKVEQLI-AGDGSLNHEYLPILG 74 Query: 94 RPSLINSLIKLYSPIYNTELKAENV--TVTTGANEGILS---CLMGLLNAGDE----VIV 144 P + ++ + + + V G + L N + V V Sbjct: 75 LPEFRANASRIALGDDSPAIAQKRVGSVQGLGGTGALRIGAEFLRRWYNGNNNTATPVYV 134 Query: 145 FEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVII 204 P ++ + G K + RG + + EKA + I+ Sbjct: 135 SSPTWENHNSVFMDAGFKDIR-----TYRYWDAAKRGLDLQGLLDDMEKA--PEFSIFIL 187 Query: 205 -NTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLT 263 HNP G T +E + + + + D Y+ +L + + Sbjct: 188 HACAHNPTGTDPTPDEWKQIAAVMKRRCLFPFFDSAYQGFASG-------SLDKDAWAVR 240 Query: 264 LTVG---------SAGKSFAATGWRIGW--VLSLNAE----LLSYAAKAHTRICFASPSP 308 V S K+F R+G V+ + + +LS K PS Sbjct: 241 YFVSEGFELFCAQSFSKNFGLYNERVGNLSVVGKDEDNVQRVLSQMEKIVRTTWSNPPSQ 300 Query: 309 LQEACANSINDALKIGYFEKMRQEYINK----FKIFTSIFDELGLP 350 A ++ ++ + ++ S + LG P Sbjct: 301 GARIVATTLTSPQLFAEWKDNVKTMADRVLLMRSELRSRLESLGTP 346 >3DR4-A nrPDB Length = 391 Score = 74.8 bits (182), Expect = 7e-14, Method: Composition-based stats. Identities = 49/336 (14%), Positives = 103/336 (30%), Gaps = 46/336 (13%) Query: 99 NSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGL-LNAGDEVIVFEPFFDQYIPNIE 157 +++ + + G + L+ + + GDEVIV + ++ Sbjct: 56 RFIVEFEKAFADYCGVKHAIACNNGTT-ALHLALVAMGIGPGDEVIVPSLTYIASANSVT 114 Query: 158 LCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTR 217 CG V V +P + +D + E IT +TKA++ P+ Sbjct: 115 YCGATPVLVDNDP-----------RTFNLDAAKLEALITPRTKAIM------PVHLYGQI 157 Query: 218 EELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATG 277 ++ + + +HN+++I D E + T + +L T G + TG Sbjct: 158 CDMDPILEVARRHNLLVIEDAA-EAVGATYRGKKSGSLGD-----CATFSFFGNAIITTG 211 Query: 278 WRIGWVLSLNAELLSYAAKAHTR------------ICFASPSPLQEACANSINDALKIGY 325 G + + + +L + + + F +A + Sbjct: 212 E-GGMITTNDDDLAAKMRLLRGQGMDPNRRYWFPIVGFNYRMTNIQAAIGLAQLERVDEH 270 Query: 326 FEKMRQE---YINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNK 382 + Y K + + + T G + + V++ E + + K Sbjct: 271 LAARERVVGWYEQKLARLGNRVTKPHVALT---GRHVFWM--YTVRLGEGLSTTRDQVIK 325 Query: 383 GKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENL 418 D + +PP + K AE Sbjct: 326 DLDALGIESRPVFHPMHIMPPYAHLATDDLKIAEAC 361 >4H51-A nrPDB Length = 420 Score = 74.8 bits (182), Expect = 7e-14, Method: Composition-based stats. Identities = 52/357 (14%), Positives = 113/357 (31%), Gaps = 40/357 (11%) Query: 37 LTNEAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKAL-DIPMVNQYSPTRGRP 95 + + A +AA + +I + P +++A++ L D+ + +Y P G Sbjct: 31 VIFDLAKRAAAAKGPKANLVIGAYRDEQGRPYPLRVVRKAEQLLLDMNLDYEYLPISGYQ 90 Query: 96 SLINSLIKLYSPIYNTELKAENVTV--TTGANEGILSCLMGLLNAGD----EVIVFEPFF 149 I+ + IY ++ EN+ T + L D + + +P + Sbjct: 91 PFIDEAV---KIIYGNTVELENLVAVQTLSGTGAVSLGAKLLTRVFDAETTPIYLSDPTW 147 Query: 150 DQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIIN---T 206 + ++ G K I D + +++FE +K I + + Sbjct: 148 PNHYGVVKAAGWK----NICTYAYYDPKTV-----SLNFEGMKKDILAAPDGSVFILHQC 198 Query: 207 PHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTV 266 HNP G ++E+ + ++ + + + D Y+ Y + S A + + + V Sbjct: 199 AHNPTGVDPSQEQWNEIASLMLAKHHQVFFDSAYQG-YASGSLDTDAYAARLFARRGIEV 257 Query: 267 ---GSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICF------ASPSPLQEACANSI 317 S K+ R G + L + A P+ + Sbjct: 258 LLAQSFSKNMGLYSERAGTLSLLLKDKTKRADVKSVMDSLIREEYTCPPAHGARLAHLIL 317 Query: 318 NDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAP--------EGTYFVLVDFSK 366 ++ +E + + + L P + F + SK Sbjct: 318 SNNELRKEWEAELSAMAERIRTMRRTVYDELLRLQTPGSWEHVINQIGMFSFLGLSK 374 >1YAA-A nrPDB Length = 412 Score = 74.5 bits (181), Expect = 9e-14, Method: Composition-based stats. Identities = 55/327 (16%), Positives = 103/327 (31%), Gaps = 40/327 (12%) Query: 57 INLGQGFF--SYSPP--QFAIKEAQKAL--DIPMVNQYSPTRGRPSLINSLIKLYSPIYN 110 ++LG G + P ++K A+K + D ++Y G PSL ++ K+ + Sbjct: 32 VDLGIGAYRDDNGKPWVLPSVKAAEKLIHNDSSYNHEYLGITGLPSLTSNAAKIIFGTQS 91 Query: 111 TELKAENVTV-----TTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVY 165 L+ + V TGA I + V + +P + ++ E G K Sbjct: 92 DALQEDRVISVQSLSGTGALH-ISAKFFSKFFPDKLVYLSKPTWANHMAIFENQGLKTAT 150 Query: 166 VPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKA---VIINTPHNPIGKVFTREELTT 222 P E ++D F AI + V+ + HNP G T E+ Sbjct: 151 YPY----------WANETKSLDLNGFLNAIQKAPEGSIFVLHSCAHNPTGLDPTSEQWVQ 200 Query: 223 LGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQL-----TLTVGSAGKSFAATG 277 + + N + + D Y+ D + + +L S K+ G Sbjct: 201 IVDAIASKNHIALFDTAYQGFATGDLDKDAYAVRLGVEKLSTVSPVFVCQSFAKNAGMYG 260 Query: 278 WRIGWV----------LSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFE 327 R+G ++ + S AK P+ + A + + Sbjct: 261 ERVGCFHLALTKQAQNKTIKPAVTSQLAKIIRSEVSNPPAYGAKIVAKLLETPELTEQWH 320 Query: 328 KMRQEYINKFKIFTSIFDELGLPYTAP 354 K ++ + + P Sbjct: 321 KDMVTMSSRITKMRHALRDHLVKLGTP 347 >2C81-A nrPDB Length = 418 Score = 73.3 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 35/173 (20%), Positives = 66/173 (38%), Gaps = 25/173 (14%) Query: 69 PQFAIKEAQKALDIPMVNQYSPT---RGRPSLINSLIKLYSPIYNTELKAENVTVTTGAN 125 PQ + + +K ++ N+++ + G S+ K ++ TT + Sbjct: 12 PQHSDRTRRKIEEVFQSNRWAISGYWTGEESMERKFAKAFADFNGVPY----CVPTTSGS 67 Query: 126 EGILSCLMGL-LNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEW 184 ++ L L + GDEVIV + + V+V + + Sbjct: 68 TALMLALEALGIGEGDEVIVPSLTWIATATAVLNVNALPVFVDVEAD-----------TY 116 Query: 185 TIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISD 237 ID + + AIT KTKA+I P+ + + + I +HN+ +I D Sbjct: 117 CIDPQLIKSAITDKTKAII------PVHLFGSMANMDEINEIAQEHNLFVIED 163 >1TAR-A nrPDB Length = 401 Score = 72.9 bits (177), Expect = 2e-13, Method: Composition-based stats. Identities = 59/371 (15%), Positives = 125/371 (33%), Gaps = 33/371 (8%) Query: 50 KNQGRELINLGQGFF-SYSPPQFAIKEAQKA----LDIPMVNQYSPTRGRPSLINSLIKL 104 ++ + +NLG G + + + + +KA M +Y P G + +L Sbjct: 24 RDTNSKKMNLGVGAYRDDNGKPYVLNCVRKAEAMIAAKKMDKEYLPIAGLADFTRASAEL 83 Query: 105 YSPIYNTELKA-ENVTV----TTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELC 159 + K+ VTV TG+ + L +V + +P + + P Sbjct: 84 ALGENSEAFKSGRYVTVQGISGTGSLRVGANFLQRFFKFSRDVYLPKPSWGNHTPIFRDA 143 Query: 160 GGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREE 219 G + + + D + ++T E K I K+ ++ HNP G +E+ Sbjct: 144 GLQ-----LQAYRYYDPKTCSL-DFTGAMEDISK-IPEKSIILLHACAHNPTGVDPRQEQ 196 Query: 220 LTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATL--SPEIGQLTLTVGSAGKSFAATG 277 L ++ K N++ D Y+ D L E G + S K+ G Sbjct: 197 WKELASVVKKRNLLAYFDMAYQGFASGDINRDAWALRHFIEQGIDVVLSQSYAKNMGLYG 256 Query: 278 WRIG-WVL----SLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQE 332 R G + + + A+ + K R +++P A+ I + ++R+E Sbjct: 257 ERAGAFTVICRDAEEAKRVESQLKILIRPMYSNPPMNGARIASLILNTP------ELRKE 310 Query: 333 YINKFKIFTSIFDELG---LPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRIS 389 ++ + K + + EG+ + + + + S Sbjct: 311 WLVEVKGMADRIISMRTQLVSNLKKEGSSHNWQHITDQIGMFCFTGLKPEQVERLTKEFS 370 Query: 390 HWLINELGVVA 400 ++ + + Sbjct: 371 IYMTKDGRISV 381 >3II0-A nrPDB Length = 422 Score = 72.9 bits (177), Expect = 2e-13, Method: Composition-based stats. Identities = 58/402 (14%), Positives = 119/402 (29%), Gaps = 47/402 (11%) Query: 57 INLGQGFFS----YSPPQFAIKEAQK--ALDIPMVNQYSPTRGRPSLINSLIKLYSPIYN 110 +NLG G + + +K+ ++ A D + ++Y P G + +L + Sbjct: 22 VNLGVGAYRTDDCHPWVLPVVKKVEQKIANDNSLNHEYLPILGLAEFRSCASRLALGDDS 81 Query: 111 TELKAENV--TVTTGANEGILSCLMGLL-------NAGDEVIVFEPFFDQYIPNIELCGG 161 LK + V + G + L N V V P ++ + G Sbjct: 82 PALKEKRVGGVQSLGGTGALRIGADFLARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGF 141 Query: 162 KVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVII-NTPHNPIGKVFTREEL 220 K + RG + E A + V++ HNP G T E+ Sbjct: 142 KDIR-----SYRYWDAEKRGLDLQGFLNDLENA--PEFSIVVLHACAHNPTGIDPTPEQW 194 Query: 221 TTLGNICVKHNVVIISDEVYEHLYFT----DSFTRIATLSPEIGQLTLTVGSAGKSFAAT 276 + ++ + D Y+ D++ +S S K+F Sbjct: 195 KQIASVMKHRFLFPFFDSAYQGFASGNLERDAWAIRYFVSEGFEFFC--AQSFSKNFGLY 252 Query: 277 GWRIGW--VLSLNAE----LLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMR 330 R+G V+ E +LS K P+ A+++++ + Sbjct: 253 NERVGNLTVVGKEPESILQVLSQMEKIVRITWSNPPAQGARIVASTLSNPELFEEWTGNV 312 Query: 331 QEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISH 390 + ++ S L GT + G + + Sbjct: 313 KTMADRILTMRSEL-RARLEALKTPGT---WNHITD--------QIGMFSFTGLNPKQVE 360 Query: 391 WLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLEN 432 +L+NE + +P + + + ++ + + Sbjct: 361 YLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIAE 402 >2OGE-A nrPDB Length = 399 Score = 72.9 bits (177), Expect = 3e-13, Method: Composition-based stats. Identities = 43/261 (16%), Positives = 84/261 (32%), Gaps = 33/261 (12%) Query: 105 YSPIYNTELKAENVTVTTGANEGILSCLMGL-LNAGDEVIVFEPFFDQYIPNIELCGGKV 163 + + + ++ + + L GL + GDEVIV + + G Sbjct: 68 FEAEFAAYCETDHAVGVNSGMDALQLALRGLGIGPGDEVIVPSHTYIASWLAVSATGATP 127 Query: 164 VYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTL 223 V V + T+D EKAIT +T+A++ P+ ++ L Sbjct: 128 VPV-----------EPHEDHPTLDPLLVEKAITPRTRALL------PVHLYGHPADMDAL 170 Query: 224 GNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWV 283 + +H + I+ D H + R + + GK+ G G V Sbjct: 171 RELADRHGLHIVEDAAQAH----GARYRGRRIGAGSSVAAFSFY-PGKNLGCFG-DGGAV 224 Query: 284 LSLNAELLSYAAKAHTRICFASPSPLQEACANSIND--ALKIGYFEKMRQEYINKFKIF- 340 ++ + EL S + + +++ A + + + Sbjct: 225 VTGDPELAERLRMLRNYGSRQKYSHETKGTNSRLDEMQAAVLRIRLAHLDSWNGRRSALA 284 Query: 341 ------TSIFDELGLPYTAPE 355 + +GLP TAP+ Sbjct: 285 AEYLSGLAGLPGIGLPVTAPD 305 >3EZ1-A nrPDB Length = 423 Score = 72.9 bits (177), Expect = 3e-13, Method: Composition-based stats. Identities = 66/417 (15%), Positives = 128/417 (30%), Gaps = 77/417 (18%) Query: 40 EAAAKAANNSKNQGRELINLGQGFF---SYSPPQFAIKEA----QKALDIPMVNQYSPTR 92 + A +A K +G L N+ +G + + + + + N Sbjct: 12 DLARQAYEAFKARGLNL-NMQRGQPADADFDLSNGLLTVLGAEDVRMDGLDLRNYPGGVA 70 Query: 93 GRPSLINSLIKLYSPIYNTELKAENVTVTTGAN---EGILSCLMGL----------LNAG 139 G PS ++KAENV V ++ +G++ L L+ Sbjct: 71 GLPSARALFAGYL------DVKAENVLVWNNSSLELQGLVLTFALLHGVRGSTGPWLSQT 124 Query: 140 DEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAI--TS 197 ++IV P +D++ ++ G +++ V + D + E+ Sbjct: 125 PKMIVTVPGYDRHFLLLQTLGFELLTVDMQSDG-------------PDVDAVERLAGTDP 171 Query: 198 KTKAV-IINTPHNPIGKVFTREELTTLGNI-CVKHNVVIISDEVY--EHLYFTDSFTRIA 253 K + + T NP G+ + E+ L + + I +D+ Y HL D + Sbjct: 172 SVKGILFVPTYSNPGGETISLEKARRLAGLQAAAPDFTIFADDAYRVHHLVEEDRAEPVN 231 Query: 254 TL----SPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPL 309 + S K G +G+ ++ + + + + +K Sbjct: 232 FVVLARDAGYPDRAFVFASTSKI-TFAGAGLGF-VASSEDNIRWLSKYLGAQSIGPNKVE 289 Query: 310 QEACANSINDALK--IGYFEKMRQEYINKFKIFTSIFD-ELG-----LPYTAPEGTYFVL 361 Q + + G KF+ + ELG +T P+G YF+ Sbjct: 290 QARHVKFLTEYPGGLEGLMRDHAAIIAPKFRAVDEVLRAELGEGGEYATWTLPKGGYFIS 349 Query: 362 VDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENL 418 +D ++ L GV P Y + NL Sbjct: 350 LDTAEPVADRVV-----------------KLAEAAGVSLTPAGATYPAGQDPHNRNL 389 >3MEB-A nrPDB Length = 448 Score = 72.5 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 49/305 (16%), Positives = 92/305 (30%), Gaps = 17/305 (5%) Query: 57 INLGQG----FFSYSPPQFAIKEAQKALDIPMVNQ---YSPTRGRPSLINSLIKLYSPIY 109 +NLG G A+KEA+ + + Y P G P + + L Sbjct: 52 VNLGVGAYRDESGKPWILPAVKEAEAIISSDLSKYNKEYPPVAGFPLFLEAAQFLMFGKD 111 Query: 110 NTELKAENV-----TVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVV 164 + + + TG+ I + L E + + + + K+ Sbjct: 112 SKAAQEGRIASCQSLSGTGSLH-IGFEFLHLWMPKAEFYMPSTTWPNHYGIYDKVFNKLK 170 Query: 165 YVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLG 224 VP L + +++ + + A K+ + HNP G FT + L Sbjct: 171 -VPYKEYTYLRKDGELEIDFSNTKKDIQSA-PEKSIFLFHACAHNPSGIDFTEAQWKELL 228 Query: 225 NICVKHNVVIISDEVYEHLYFTDSFTRIAT--LSPEIGQLTLTVGSAGKSFAATGWRIGW 282 I + + D Y+ + + G L S K+F G RIG Sbjct: 229 PIMKEKKHIAFFDSAYQGFATGSFEADAFAVRMFVDAGVEVLVAQSFSKNFGLYGERIGC 288 Query: 283 VLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTS 342 + ++A + K + A+ Y ++ ++F Sbjct: 289 LHVVHAGVEGSVEKNKALSAAMVSGMTLQIRKTWSMSAIHGAYIVQVIVHDKRLLQMFYD 348 Query: 343 IFDEL 347 E+ Sbjct: 349 NVKEM 353 >2X8U-A nrPDB Length = 412 Score = 70.6 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 54/350 (15%), Positives = 111/350 (31%), Gaps = 43/350 (12%) Query: 11 NLMSTSRPKVVANKYFTSNTAKDVWSLTNEAAAKAANNSKNQGRELINLG----QGFFSY 66 +L+S P + + + +D +++ + N GR+ I LG G ++ Sbjct: 2 DLLSKFDPLIAEREALLATGVRDPYAIVMDKVLSPTEAMIN-GRKTILLGTYNYMG-MTF 59 Query: 67 SPPQFAIKEAQKALDIPMVNQYS------PTRGRPSLINSLIKLYSPIYNTELKAENVTV 120 P I ++ALD +G + ++L + Y + + Sbjct: 60 DP--DVIAAGKQALDEFGSGTTGSRVLNGTYQGHKACEDALKEFYGTEHA-------IVF 110 Query: 121 TTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTR 180 +TG + L + L GD +I+ L ++V N ++LD+R R Sbjct: 111 STG-YQANLGMISTLAGKGDYIILDADSHASIYDGCWLGDAEIVRFRHNSVEDLDKRLGR 169 Query: 181 GEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVY 240 E + + L + + KH +I+ DE + Sbjct: 170 LPAEAGKLVVLEGVYS----------------MMGDIAPLQEMVAVSKKHGAMILVDEAH 213 Query: 241 EHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTR 300 +F + + + + VG+ KS G G+ +S + + + R Sbjct: 214 GMGFFGEHGRGVFEEAGVEADVDFVVGTFSKSVGTVG---GFCVSNHPKF--EVLRLVCR 268 Query: 301 ICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLP 350 + S A + K+ + R + ++G Sbjct: 269 PYVFTASLPPSVVATAATSIRKLMHAGDKRAHLWKNSRRLHQGLRDMGYK 318 >1M6S-A nrPDB Length = 347 Score = 70.6 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 51/290 (17%), Positives = 89/290 (30%), Gaps = 39/290 (13%) Query: 74 KEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLM 133 +E +KA+ V G IN L +L + + E G +M Sbjct: 18 EEMRKAMAQAEVGD--DVYGEDPTINELERLAAETFG----KEAALFVPSGTMGNQVSIM 71 Query: 134 GLLNAGDEVIVFEP---FFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQ 190 GDEVI+ F+ + L G VP G+ +D + Sbjct: 72 AHTQRGDEVILEADSHIFWYEVGAMAVLSGVMPHPVP-------------GKNGAMDPDD 118 Query: 191 FEKAITSK------TKAVIINTPHNPIG-KVFTREELTTLGNICVKHNVVIISDEVYEHL 243 KAI + T + I HN G +V E + + I +H + + D Sbjct: 119 VRKAIRPRNIHFPRTSLIAIENTHNRSGGRVVPLENIKEICTIAKEHGINVHID---GAR 175 Query: 244 YFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICF 303 F S + G + K A +G V+ + + + A KA + Sbjct: 176 IFNASIASGVPVKEYAGYADSVMFCLSKGLCAP---VGSVVVGDRDFIERARKARKMLG- 231 Query: 304 ASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTA 353 +++A + + + +E + E+G Sbjct: 232 ---GGMRQAGVLAAAGIIALTKMVDRLKEDHENARFLALKLKEIGYSVNP 278 >1MDZ-A nrPDB Length = 393 Score = 69.8 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 31/156 (19%), Positives = 55/156 (35%), Gaps = 27/156 (17%) Query: 96 SLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGL-LNAGDEVIVFEPFFDQYIP 154 L + +L Y + + A G+ LM L + GDEVI + + Sbjct: 43 ELEAAFCRLTGNQYAVAVSS--------ATAGMHIALMALGIGEGDEVITPSMTWVSTLN 94 Query: 155 NIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKV 214 I L G V V ++ + + E E AIT +TKA+I P+ Sbjct: 95 MIVLLGANPVMVDVDRDTLM-----------VTPEHIEAAITPQTKAII------PVHYA 137 Query: 215 FTREELTTLGNICVKHNVVIISDEVYE-HLYFTDSF 249 +L + + ++ + +I D + + Sbjct: 138 GAPADLDAIYALGERYGIPVIEDAAHATGTSYKGRH 173 >2HOR-A nrPDB Length = 427 Score = 69.1 bits (167), Expect = 4e-12, Method: Composition-based stats. Identities = 47/364 (12%), Positives = 114/364 (31%), Gaps = 65/364 (17%) Query: 96 SLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLL--------NAGDEVIVFEP 147 L ++ +L+ + N K + G + I ++ L +V+ P Sbjct: 104 ELEKTIKELHEVVGNAAAKDRYIVFGVGVTQLIHGLVISLSPNMTATPDAPESKVVAHAP 163 Query: 148 FFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTP 207 F+ + + + +G W + + + ++ +P Sbjct: 164 FYPVFREQTK------------------YFDKKGYVWAGNAANYVNVSNPEQYIEMVTSP 205 Query: 208 HNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVG 267 +NP G + + C +Y+ +Y+ +T I + E + + Sbjct: 206 NNPEGLL-----RHAVIKGCK---------SIYDMVYYWPHYTPIKYKADED----ILLF 247 Query: 268 SAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSIND-----ALK 322 + K +G R GW L + + + T+ +P Q + + + Sbjct: 248 TMSKFTGHSGSRFGWALIKDESVYNNLLNYMTKNTEGTPRETQLRSLKVLKEVVAMVKTQ 307 Query: 323 IGYFEKMRQEYINKFKI----FTSIFDEL-GLPYTA-PEGTYFVLVDFSKVKIPEDYPYP 376 G + K + T++ D+ Y P+ Y F +++ P P Sbjct: 308 KGTMRDLNTFGFKKLRERWVNITALLDQSDRFSYQELPQSEYCNY--FRRMRPPS--PSY 363 Query: 377 EEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVER 436 + + ++ + + + F +A+ +R ++ K + + Sbjct: 364 AWVKCEWEEDKDCYQTFQNGRINTQNGVGF------EASSRYVRLSLIKTQDDFDQLMYY 417 Query: 437 LKLL 440 LK + Sbjct: 418 LKDM 421 >4PIW-A nrPDB Length = 396 Score = 68.7 bits (166), Expect = 5e-12, Method: Composition-based stats. Identities = 31/175 (17%), Positives = 55/175 (31%), Gaps = 25/175 (14%) Query: 66 YSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGAN 125 ++ P E + G + + + V +T Sbjct: 24 FNAPPVVGTELDYMQSAMGSGKLC---GDGGFTRRCQQWLEQRFG----SAKVLLTPSCT 76 Query: 126 EGILSCLMGL-LNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEW 184 + + L + GDEVI+ F L G K+V+V + P Sbjct: 77 ASLEMAALLLDIQPGDEVIMPSYTFVSTANAFVLRGAKIVFVDVRPDTMNIDETL----- 131 Query: 185 TIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEV 239 E AIT KT+ ++ P+ E+ T+ + KHN+ ++ D Sbjct: 132 ------IEAAITDKTRVIV------PVHYAGVACEMDTIMALAKKHNLFVVEDAA 174 >5TON-A nrPDB Length = 414 Score = 68.7 bits (166), Expect = 5e-12, Method: Composition-based stats. Identities = 51/323 (15%), Positives = 96/323 (29%), Gaps = 37/323 (11%) Query: 57 INLGQGFFSYSPPQF-----AIKEAQK-ALDIPMVNQYSPTRGRPSLINSLIKLYSPIYN 110 +NLG G + Q K Q+ A + + ++Y P G +L + Sbjct: 35 VNLGVGAYRTDDCQPWVLPVVRKVEQRIANNSSLNHEYLPILGLAEFRTCASRLALGDDS 94 Query: 111 TELKAENV--TVTTGANEGILSCLMGLL-------NAGDEVIVFEPFFDQYIPNIELCGG 161 L+ + V + G + L N V V P ++ G Sbjct: 95 PALQEKRVGGVQSLGGTGALRIGAEFLARWYNGTNNKDTPVYVSSPTWENLNGVFTTAGF 154 Query: 162 KVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVII-NTPHNPIGKVFTREEL 220 K + RG + E A + ++ HNP G T E+ Sbjct: 155 KDIR-----SYRYWDTEKRGLDLQGFLSDLENA--PEFSIFVLHACAHNPTGTDPTPEQW 207 Query: 221 TTLGNICVKHNVVIISDEVYEHLYFTDSFTR---IATLSPEIGQLTLTVGSAGKSFAATG 277 + ++ + + D Y+ + I E +L S K+F Sbjct: 208 KQIASVMKRRFLFPFFDSAYQGFASGNLEKDAWAIRYFVSEGFELF-CAQSFSKNFGLYN 266 Query: 278 WRIGW--VLSLNAELLSYAAKAHTRIC----FASPSPLQEACANSINDALK----IGYFE 327 R+G V++ + + +I P+ A +++D G + Sbjct: 267 ERVGNLTVVAKEPDSILRVLSQMQKIVRVTWSNPPAQGARIVARTLSDPELFHEWTGNVK 326 Query: 328 KMRQEYINKFKIFTSIFDELGLP 350 M ++ + + L P Sbjct: 327 TMADRILSMRSELRARLEALKTP 349 >5W1B-A nrPDB Length = 467 Score = 67.9 bits (164), Expect = 9e-12, Method: Composition-based stats. Identities = 68/393 (17%), Positives = 135/393 (34%), Gaps = 45/393 (11%) Query: 79 ALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELK----AENVTVTTGANEGILSCLMG 134 A I Y+ +R L + +L++ Y AEN+ +L Sbjct: 63 AAMITGDEAYAGSRNYYDLKDKAKELFNYDYIIPAHQGRGAENILF-----PVLLKYKQK 117 Query: 135 LLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKA 194 A + V + FD ++EL G K + I K D + D ++ ++ Sbjct: 118 EGKAKNPVFISNFHFDTTAAHVELNGCKA--INIVTEKAFDSETYDDWKGDFDIKKLKEN 175 Query: 195 ITSK-----TKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEV-YEHLYFTDS 248 I V T ++ G+ + L + I +H + ++ D + + Sbjct: 176 IAQHGADNIVAIVSTVTCNSAGGQPVSMSNLKEVYEIAKQHGIFVVMDSARFCENAYFIK 235 Query: 249 FTRIATLSPEIGQLTLTVGSAGKSFAATG-----WRIGWVLSL--NAELLSYAAKAHTRI 301 + I ++ + + + IG ++++ N E+ + A + + Sbjct: 236 ARDPKYKNATIKEVIFDMYKYADALTMSAKKDPLLNIGGLVAIRDNEEIFTLARQRCVPM 295 Query: 302 -CFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFV 360 F + L ++ L+ G E+ I + K E G+P P G + V Sbjct: 296 EGFVTYGGLAGRDMAAMVQGLEEGTEEEYLHYRIGQVKYLGDRLREAGIPIQYPTGGHAV 355 Query: 361 LVDFSKV--KIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAEN- 417 VD K+ +IP D + ++N L E GV A+ F + E Sbjct: 356 FVDCKKLVPQIPGDQFPAQAVINA---------LYLESGVRAVEIGSFLLGRDPATGEQK 406 Query: 418 -----LLRFAVCK---DDAYLENAVERLKLLKD 442 +R + + + +++ + L LK+ Sbjct: 407 HADMEFMRLTIARRVYTNDHMDYIADALIGLKE 439 >5XT5-A nrPDB Length = 419 Score = 67.5 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 68/437 (15%), Positives = 129/437 (29%), Gaps = 98/437 (22%) Query: 53 GRELINLGQGFFSYSPPQFAIKEAQKALDIPMVN--------QYSPTRGRPSLINSLIKL 104 G +L+ L S P+ I+ K + N T G + K Sbjct: 22 GHDLVYLDSAATS-QKPRAVIETLDKYYNQYNSNVHRGVHTLGTRATDGYEGAREKVRKF 80 Query: 105 YSPIYNTELKAENVTVTTGANEGILSCL----MGLLNAGDEVIVFEPFFD-------QYI 153 + + T G + L GDEV++ + + Sbjct: 81 INAK-----SMAEIIFTKGTTTSLNMVALSYARANLKPGDEVVI---TYMEHHANIIPWQ 132 Query: 154 PNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGK 213 ++ G + Y+P+ E+ TI E + +TS TK V ++ N +G Sbjct: 133 QAVKATGATLKYIPLQ------------EDGTISLEDVRETVTSNTKIVAVSHVSNVLGT 180 Query: 214 VFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSF 273 V +E+ + + VI+ D T + + S+ K Sbjct: 181 VNPIKEMAKI---AHDNGAVIVVD--------GAQSTPHMKIDVQDLDCDFFALSSHKMC 229 Query: 274 AATGWRIGWVLSLNA------------ELLSYAAKAHTR-----ICFASPSPLQEACA-- 314 TG +G + A E++ + + F + +P+ Sbjct: 230 GPTG--VGVLYGKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTPIIAGAIGL 287 Query: 315 -NSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDY 373 +I+ +IG E R E+ G+ PE + + + Sbjct: 288 GAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPE----ERAGLVTFNLDDVH 343 Query: 374 PYPEEILNKGKDFRI------SHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDD 427 P+ + + + + L+ L V A FY + + Sbjct: 344 PHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFY---------------LYNTE 388 Query: 428 AYLENAVERLKLLKDYL 444 ++ VE L+ K+Y Sbjct: 389 EEIDKLVEALQKTKEYF 405 >6BLG-A nrPDB Length = 379 Score = 65.2 bits (157), Expect = 5e-11, Method: Composition-based stats. Identities = 36/178 (20%), Positives = 62/178 (34%), Gaps = 31/178 (17%) Query: 66 YSPPQFA---IKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTT 122 ++ P + Q A++ + G + + T +T Sbjct: 7 FNAPPVVGTELDYMQSAMNSGKLC------GDGGFTRRCQQWMEQRFGTA----KALLTP 56 Query: 123 GANEGILSCLMGL-LNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRG 181 + + L + GDEVI+ F L G K+V+V I R Sbjct: 57 SCTASLEMAALLLDIQPGDEVIMPSYTFVSTANAFVLRGAKIVFVDI-----------RR 105 Query: 182 EEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEV 239 + ID E AIT KT+A++ P+ E+ T+ I K+N+ ++ D Sbjct: 106 DTMNIDETLIEAAITDKTRAIV------PVHYAGVACEMDTIMAIADKYNLFVVEDAA 157 >5K8B-A nrPDB Length = 403 Score = 64.8 bits (156), Expect = 8e-11, Method: Composition-based stats. Identities = 29/122 (23%), Positives = 52/122 (42%), Gaps = 20/122 (16%) Query: 119 TVTTGANEGILSCLMGL-LNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQR 177 +++G + + +M + AGDEVIV F + I + G ++ I+ Sbjct: 57 LLSSG-TAALQTAMMAAGIGAGDEVIVPPFTFVASVEAIFMAGAVPIFAEID-------- 107 Query: 178 NTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISD 237 E + E E IT +TKA+ N + + ++ + IC KHN+V++ D Sbjct: 108 ----ETLCLSPEGIEAVITPRTKAI------NLVHMCGSMAKMDEIKAICKKHNLVLLED 157 Query: 238 EV 239 Sbjct: 158 AC 159 >4W91-A nrPDB Length = 422 Score = 64.4 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 67/423 (15%), Positives = 128/423 (30%), Gaps = 67/423 (15%) Query: 52 QGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPT-RGRPSLINSLIKLYS---- 106 G+ L+ L G S PQ I A N+Y+ RG L N+ Y Sbjct: 36 HGKTLVYLDNGA-SAQKPQSVIDAVTHAY----ANEYANVHRGLHFLSNAATDAYEKSRE 90 Query: 107 --PIYNTELKAENVTVTTGANEGILSCLMG----LLNAGDEV---IVFEPF-FDQYIPNI 156 + + + T A E I + G + GDE+ I+ + Sbjct: 91 TVRRFLNAGSVDEIVFTKNATEAINTVAYGYGMPFIGEGDEILLSIMEHHSNIVPWHFIR 150 Query: 157 ELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFT 216 E G K+V+ P++ + E+FEK ++ +TK V I N +G V Sbjct: 151 ERQGAKLVFTPVD------------DNGVFHIEEFEKRLSERTKLVAITHMSNTLGTVVP 198 Query: 217 REELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAAT 276 + + + + ++ D + + ++G K + + Sbjct: 199 ---IKKIVELAHARGIPVLVDG-------SQGAVHLPVDVQDLGCDWYVFTGH-KVYGPS 247 Query: 277 GWRIGWVLSLNAELLSYAAKAHT-----------RICFASPSPLQEACANSINDALKIG- 324 G IG + A++L + + P EA I A+ +G Sbjct: 248 G--IGVLYG-RAQMLEKMRPFQGGGEMIEEVTEENVTYNHPPHRFEAGTPPIVQAIGLGA 304 Query: 325 YFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGK 384 E M + + + + + + + D +G Sbjct: 305 ALEYMEKIGRHAILAHEADLRDYAHERLGRINSLRIFGNAP------DKGAIISFALEGI 358 Query: 385 DFRISHWLINELGVVAIPPTEFYIKEHEKAA-ENLLRFAVC--KDDAYLENAVERLKLLK 441 +I+ GV T ++ + R + A ++ E L+ + Sbjct: 359 HAHDVSMVIDRAGVAVRAGTHCAQPLLKRFGVTSTCRASFALYNTRAEVDALAEALEKAR 418 Query: 442 DYL 444 + Sbjct: 419 KFF 421 >1B9H-A nrPDB Length = 388 Score = 64.1 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 31/181 (17%), Positives = 56/181 (30%), Gaps = 25/181 (13%) Query: 64 FSYSP-PQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTT 122 + PQ+ E + Q+ G + + A + VT Sbjct: 7 PEFPAWPQYDDAERNGLVRALEQGQWWRMGG-----DEVNSFEREFAAHHGAAHALAVTN 61 Query: 123 GANEGILSCLMGL-LNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRG 181 G + L + + G EVIV F + G V V ++ Sbjct: 62 G-THALELALQVMGVGPGTEVIVPAFTFISSSQAAQRLGAVTVPVDVDA----------- 109 Query: 182 EEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYE 241 + +D E A+T +TK ++ P+ ++ L I V ++ D + Sbjct: 110 ATYNLDPEAVAAAVTPRTKVIM------PVHMAGLMADMDALAKISADTGVPLLQDAAHA 163 Query: 242 H 242 H Sbjct: 164 H 164 >5C6U-A nrPDB Length = 435 Score = 63.7 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 41/320 (12%), Positives = 88/320 (27%), Gaps = 63/320 (19%) Query: 81 DIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLL---- 136 + Y G P L +L + N+ ++ ++ ++ Sbjct: 61 EGTDTRNYGGQHGLPGLRAIFAELLG------IAVPNLIAGNNSSLELMHDIVAFSMLYG 114 Query: 137 -----------NAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWT 185 G + + P +D++ E G +++ +P+ Sbjct: 115 GVDSPRPWIQEQDGIKFLCPVPGYDRHFAITETMGIEMIPIPMLQDG------------- 161 Query: 186 IDFEQFEK--AITSKTKAVI-INTPHNPIGKVFTREELTTLGNICVKH-NVVIISDEVYE 241 D + E+ A+ K + + NP G ++ E + L + + + D Y Sbjct: 162 PDVDLIEELVAVDPAIKGMWTVPVFGNPSGVTYSWETVRRLVQMRTAAPDFRLFWDNAYA 221 Query: 242 HLYFTDSFTRIATLS-----PEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAK 296 T F R + S K I + + Sbjct: 222 VHTLTLDFPRQVDVLGLAAKAGNPNRPYVFASTSK--------ITFAGGGVSFFGGSLGN 273 Query: 297 AHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIF------------ 344 + +A + N + G + +R + +I F Sbjct: 274 IAWYLQYAGKKSIGPDKVNQLRHLRFFGDADGVRLHMLRHQQILAPKFALVAEVLDQRLS 333 Query: 345 DELGLPYTAPEGTYFVLVDF 364 + +T P+G YF+ +D Sbjct: 334 ESKIASWTEPKGGYFISLDV 353 >3K7Y-A nrPDB Length = 405 Score = 63.3 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 41/258 (15%), Positives = 75/258 (29%), Gaps = 20/258 (7%) Query: 36 SLTNEAAAKAANNSKNQG-RELINLGQGFFSYSPPQ-FAIKEAQKALDIPMVNQ----YS 89 ++ + K A K E INL G A + N Y Sbjct: 10 NIEVDNILKTAREFKEDTCEEKINLSIGVCCNDDGDLHIFDSVLNADKLVTENYKEKPYL 69 Query: 90 PTRGRPSLINSLIKLYSPIYNTELKAENV--TVTTGANEGILSCLMGLLNAGDEVI-VFE 146 G L + ++ + + G I L L E + V Sbjct: 70 LGNGTEDFSTLTQNLIFGNNSKYIEDKKICTIQCIGGTGAIFVLLEFLKMLNVETLYVTN 129 Query: 147 PFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINT 206 P + ++ IE G + Y+ +D + + I + + ++ + Sbjct: 130 PPYINHVNMIESRGFNLKYINFFDYNLIDI------NYDLFLNDLRN-IPNGSSVILQIS 182 Query: 207 PHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTL-- 264 +NP + + I + VII D Y+ T+ L + + + Sbjct: 183 CYNPCSVNIEEKYFDEIIEIVLHKKHVIIFDIAYQGFGHTN-LEEDVLLIRKFEEKNIAF 241 Query: 265 -TVGSAGKSFAATGWRIG 281 S K+ + G R G Sbjct: 242 SVCQSFSKNMSLYGERAG 259 >4OC9-A nrPDB Length = 424 Score = 62.9 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 42/244 (17%), Positives = 76/244 (31%), Gaps = 35/244 (14%) Query: 118 VTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQR 177 + V +G L+ L ++GD V + ++ GG + L Sbjct: 79 IPVASG-MAACFYALINLASSGDNV-----AYSN-----KIYGGTQTLI----SHTLKNF 123 Query: 178 NTRGEEWTID-FEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIIS 236 E+ ID + EK I TKA+ + NP ++ + I KH +V I Sbjct: 124 GIEAREFDIDDLDSLEKVIDQNTKAIFFESLSNP---QIAIADIEKINQIAKKHKIVSIC 180 Query: 237 DEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAK 296 D ++ L P + + V S K + G +G L +L Sbjct: 181 D---------NTVATPFLLQPFKHGVDVIVHSLSKYVSGQGTALGGALIERKDLNDLLKN 231 Query: 297 AHTRICFASPSPLQEAC-ANSINDALK-----IGYFEKMRQEYI-NKFKIFTSIFDELGL 349 F +P P N+++ + I + + + + L + Sbjct: 232 NDRYKAFNTPDPSYHGLNLNTLDLPIFSIRVIITWLRDLGASLAPQNAWLLLQGLETLAV 291 Query: 350 PYTA 353 Sbjct: 292 RIEK 295 >3VK2-A nrPDB Length = 398 Score = 62.1 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 34/158 (21%), Positives = 53/158 (33%), Gaps = 33/158 (20%) Query: 124 ANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELC----GGKVVYVPINPPKELDQRNT 179 I S L LL GDEV++ + + G K+ +V + Sbjct: 89 GMGAITSTLWTLLRPGDEVLLGNTLYGHTFAFLHHGIGEFGVKLRHVDMA---------- 138 Query: 180 RGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEV 239 D + E A+T T+ + +P NP ++ + I KH ++ D Sbjct: 139 -------DLQALEAAMTPATRVIYFESPANP---NMHMADIAGVAKIARKHGATVVVDNT 188 Query: 240 YEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATG 277 Y T R L + L V SA K + G Sbjct: 189 YC----TPYLQRPLELGAD-----LVVHSATKYLSGHG 217 >5W70-A nrPDB Length = 445 Score = 61.4 bits (147), Expect = 7e-10, Method: Composition-based stats. Identities = 27/165 (16%), Positives = 51/165 (30%), Gaps = 22/165 (13%) Query: 74 KEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLM 133 L + P RG S + ++ + ++ L Sbjct: 51 DAVADVLGSGRWSISGPYRGTESYERRFARAFAAYNGVP----HCVPAASGTASLMLALE 106 Query: 134 GL-LNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFE 192 + AGDEVIV + I ++ ++P + E E Sbjct: 107 ACGIGAGDEVIVPGLSWVASGSTILGVNAVPIFCDVDPD-----------TLCLSPEAVE 155 Query: 193 KAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISD 237 AIT T+A+++ + ++ L I +H + +I D Sbjct: 156 AAITEHTRAIVV------VHLYSALADMDALSAIAERHGLPLIED 194 >3A2B-A nrPDB Length = 398 Score = 60.6 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 65/431 (15%), Positives = 138/431 (32%), Gaps = 75/431 (17%) Query: 24 KYFTSNTAKDVWSLTNEAAAKAANNSKNQGRELINLGQGFF-SYSPPQFAIKEAQKALDI 82 K AK +++ +K K GR ++ G + + IK AQ AL+ Sbjct: 13 KIVEELKAKGLYAYFRPIQSKQDTEVKIDGRRVLMFGSNSYLGLTTDTRIIKAAQDALE- 71 Query: 83 PMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSC----------L 132 +Y + + + + ++ E E + L Sbjct: 72 ----KYGTG-------CAGSRFLNGTLDIHVELEEKLSAYVGKEAAILFSTGFQSNLGPL 120 Query: 133 MGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFE 192 L+ D +++ E I L KV+ N ++L + +R E Sbjct: 121 SCLMGRNDYILLDERDHASIIDGSRLSFSKVIKYGHNNMEDLRAKLSRLPE--------- 171 Query: 193 KAITSKTKAVIINTPHNPIGKVFTRE----ELTTLGNICVKHNVVIISDEVYEHLYFTDS 248 K + +F+ E L L +I + + ++ D+ + Sbjct: 172 ----DSAKLIC-------TDGIFSMEGDIVNLPELTSIANEFDAAVMVDDAHSLGVIGHK 220 Query: 249 FTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSP 308 A+ + L +G+ KS A+ G G+V +A+++ + K + R S S Sbjct: 221 GAGTASHFGLNDDVDLIMGTFSKSLASLG---GFVAG-DADVIDFL-KHNARSVMFSASM 275 Query: 309 LQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVK 368 + A+++ I + ++ + + G G Sbjct: 276 TPASVASTLKALEIIQNEPEHIEKLWKNTDYAKAQLLDHGFDL----GA----------- 320 Query: 369 IPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCK--D 426 + P + + ++ + GV P + A E+L+RF++ Sbjct: 321 --TESPILPIFIRSNEKTFWVTKMLQDDGVFVNPV----VSPAVPAEESLIRFSLMATHT 374 Query: 427 DAYLENAVERL 437 ++ A+E++ Sbjct: 375 YDQIDEAIEKM 385 >3BB8-A nrPDB Length = 437 Score = 59.1 bits (141), Expect = 4e-09, Method: Composition-based stats. Identities = 30/142 (21%), Positives = 50/142 (35%), Gaps = 26/142 (18%) Query: 105 YSPIYNTELKAENVTVTTGANEGILSCLMGL---------LNAGDEVIVFEPFFDQYIPN 155 + L V TT + L L L L GDEVI F + Sbjct: 67 FEKKLGEYLGVPYVLTTTSGSSANLLALTALTSPKLGVRALKPGDEVITVAAGFPTTVNP 126 Query: 156 IELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVF 215 G V+V ++ P + ++ E A++ KTKA++I + Sbjct: 127 TIQNGLIPVFVDVDIP-----------TYNVNASLIEAAVSDKTKAIMI------AHTLG 169 Query: 216 TREELTTLGNICVKHNVVIISD 237 +L + + K+N+ +I D Sbjct: 170 NLFDLAEVRRVADKYNLWLIED 191 >3MKJ-A nrPDB Length = 398 Score = 58.3 bits (139), Expect = 6e-09, Method: Composition-based stats. Identities = 32/177 (18%), Positives = 58/177 (32%), Gaps = 25/177 (14%) Query: 119 TVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRN 178 T I + L+ L GD ++ + G ++ + PK + Sbjct: 83 LATASGISAITTTLLTLCQQGDHIV----------SASAIYGCTHAFLSHSMPKFGINVS 132 Query: 179 TRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDE 238 E+ A+ +TK V I TP NP + ++ T+ I + +++ D Sbjct: 133 FVD---AAKPEEIRAAMRPETKVVYIETPANPT---LSLVDIETVAGIAHQQGALLVVD- 185 Query: 239 VYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAA 295 ++F P + V S K G IG ++ E + A Sbjct: 186 --------NTFMSPYCQQPLQLGADIVVHSVTKYINGHGDVIGGIIVGKQEFIDQAR 234 >4LW2-A nrPDB Length = 404 Score = 58.3 bits (139), Expect = 6e-09, Method: Composition-based stats. Identities = 60/386 (15%), Positives = 123/386 (31%), Gaps = 63/386 (16%) Query: 69 PQFAIKEAQKALDIPMVN----QYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGA 124 P+ ++ Q+ + N Q++ + + + + + + N + + T G Sbjct: 35 PEAVVEATQQFYSLSAGNVHRSQFAEAQRLTARYEAAREKVAQLLNAP-DDKTIVWTRGT 93 Query: 125 NEGILSCLMGL----LNAGDEVIV----FEPFFDQYIPNIELCGGKVVYVPINPPKELDQ 176 E I L GDE+IV ++ + G KVV +P+N + Sbjct: 94 TESINMVAQCYARPRLQPGDEIIVSVAEHHANLVPWLMVAQQTGAKVVKLPLNAQR---- 149 Query: 177 RNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIIS 236 D + + IT +++ + + N G +L +V++ Sbjct: 150 --------LPDVDLLPELITPRSRILALGQMSNVTGGC---PDLARAITFAHSAGMVVMV 198 Query: 237 DEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAG--KSFAATGWRIGWVLSLNAELLS-- 292 D ++F ++ QL + + K + TG IG + + L + Sbjct: 199 DGAQGAVHFPA----------DVQQLDIDFYAFSGHKLYGPTG--IGVLYGKSELLEAMS 246 Query: 293 ------YAAKAHTRICFASPSPLQEACANSINDALKIG---YFEKMRQEYINKFKIFTSI 343 + F + S + A + N A IG E + IN+ + ++ Sbjct: 247 PWLGGGKMVHEVSFDGFTTQSAPWKLEAGTPNVAGVIGLSAALEWLADYDINQAESWSRS 306 Query: 344 FD---------ELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRIS-HWLI 393 G + + + DF+ V + E + + L+ Sbjct: 307 LATLAEDALAKRPGFRSFRCQDSSLLAFDFAGVHHSDMVTLLAEYGIALRAGQHCAQPLL 366 Query: 394 NELGVVAIPPTEFYIKEHEKAAENLL 419 ELGV F + + L+ Sbjct: 367 AELGVTGTLRASFAPYNTKSDVDALV 392 >3QI6-A nrPDB Length = 392 Score = 57.9 bits (138), Expect = 8e-09, Method: Composition-based stats. Identities = 32/185 (17%), Positives = 58/185 (31%), Gaps = 29/185 (15%) Query: 127 GILSCLMGLLNAGDEVIVFEPFFDQYIPNIE--LCGGKVVYVPINPPKELDQRNTRGEEW 184 L +L GD V++ + + I+ G V Y P+ Sbjct: 93 AADCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTGWNVEYTPVAL-------------- 138 Query: 185 TIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLY 244 D + AI T+ + + TP NP+ + ++ + + + ++ D Sbjct: 139 -ADLDAVRAAIRPTTRLIWVETPTNPL---LSIADIAGIAQLGADSSAKVLVD------- 187 Query: 245 FTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFA 304 ++F A P + + S K +G L N E L + A Sbjct: 188 --NTFASPALQQPLSLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDQSFAFLQNGAGA 245 Query: 305 SPSPL 309 P P Sbjct: 246 VPGPF 250 >1O69-A nrPDB Length = 394 Score = 57.9 bits (138), Expect = 9e-09, Method: Composition-based stats. Identities = 40/239 (16%), Positives = 76/239 (31%), Gaps = 35/239 (14%) Query: 66 YSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGAN 125 + P K ++ + Y G + + K+EN A Sbjct: 4 FLSPPHMGGNELKYIEEVFKSNYIAPLG------EFVNRFEQSVKDYSKSENALALNSAT 57 Query: 126 EGILSCLMGL-LNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEW 184 + L + D V+ F + I K V++ + E + Sbjct: 58 AALHLALRVAGVKQDDIVLASSFTFIASVAPICYLKAKPVFIDCD------------ETY 105 Query: 185 TIDFEQFEKAITS---KTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYE 241 ID + + AI K KA+I+ ++ + IC ++++V+I D Sbjct: 106 NIDVDLLKLAIKECEKKPKALIL------THLYGNAAKMDEIVEICKENDIVLIEDAA-- 157 Query: 242 HLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTR 300 SF + L G+ + + K +G G ++ N E + A T+ Sbjct: 158 --EALGSFYKNKALG-TFGEFGVYSYNGNKIITTSG--GGMLIGKNKEKIEKARFYSTQ 211 >1ECX-A nrPDB Length = 384 Score = 56.7 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 47/360 (13%), Positives = 110/360 (30%), Gaps = 66/360 (18%) Query: 111 TELKAENVTVTTGANEGILSCLMGLLNAGD---EVIVFEP----FFDQYIPNIELCGGKV 163 + + T+ A E I L + + I+ P + + + + G KV Sbjct: 57 LGVSPSEIFFTSCATESINWILKTVAETFEKRKRTIITTPIEHKAVLETMKYLSMKGFKV 116 Query: 164 VYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTL 223 YVP++ + E+ EK + T V I +N +G + E++T + Sbjct: 117 KYVPVD------------SRGVVKLEELEKLVDEDTFLVSIMAANNEVGTIQPVEDVTRI 164 Query: 224 GNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAG--KSFAATGWRIG 281 K ++ D V I + + +L + S K G I Sbjct: 165 VKKKNK-ETLVHVDAV----------QTIGKIPFSLEKLEVDYASFSAHKFHGPKGVGIT 213 Query: 282 WV---LSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFK 338 ++ + + + + R + + A + + + + Sbjct: 214 YIRKGVPIRPLIHGGGQERGLRSGTQNVPGIVGAARAM---EIAVEELSEAAKHMEKLRS 270 Query: 339 IFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGV 398 S LG P ++ +P + L++ G+ Sbjct: 271 KLVSGLMNLGAHIITP----------LEISLPNTLSVSFPNIRGST----LQNLLSGYGI 316 Query: 399 VAIPPTEFYIKE------------HEKAAENLLRFAVCK--DDAYLENAVERLKLLKDYL 444 + K+ + A+ +R ++CK + ++ +++++ + +L Sbjct: 317 YVSTSSACTSKDERLRHVLDAMGVDRRIAQGAIRISLCKYNTEEEVDYFLKKIEEILSFL 376 >2GMS-A nrPDB Length = 390 Score = 56.7 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 30/187 (16%), Positives = 64/187 (34%), Gaps = 44/187 (23%) Query: 118 VTVTTGANE------GILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPP 171 V V++G+ + L GDE+IV + ++ G +V +V I+ Sbjct: 53 VMVSSGSTANLLMIAALFFTKKPRLKKGDEIIVPAVSWSTTYYPLQQYGLRVKFVDID-- 110 Query: 172 KELDQRNTRGEEWTIDFEQFEKAITSKTKAV----IINTPHNPIGKVFTREELTTLGNIC 227 ID E ++A+T TKA+ ++ P+N + I Sbjct: 111 ---------INTLNIDIESLKEAVTDSTKAILTVNLLGNPNN----------FDEINKII 151 Query: 228 VKHNVVIISDEVYE-HLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFA--ATGWRIGWVL 284 +++++ D F + L +G+ ++ G ++ Sbjct: 152 GGRDIILLEDNCESMGATFNNKCAGTFGL----------MGTFSSFYSHHIATMEGGCIV 201 Query: 285 SLNAELL 291 + + E+ Sbjct: 202 TDDEEIY 208 >4BMK-A nrPDB Length = 442 Score = 56.4 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 50/325 (15%), Positives = 101/325 (31%), Gaps = 37/325 (11%) Query: 33 DVWSLTNEAAAKAANNSKNQGRELINLG----QGF-FSYSPPQFAIKEAQKALDIPMVNQ 87 D +++ E K+ + +G++ I LG G F + +K ++ Sbjct: 66 DPFAIVMEQV-KSPTEAVIRGKDTILLGTYNYMGMTFDPDVIAAGKEALEKFGSGTNGSR 124 Query: 88 Y--SPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVF 145 + +L Y + +TG L + L G+ VI+ Sbjct: 125 MLNGTFHDHMEVEQALRDFYG-------TTGAIVFSTG-YMANLGIISTLAGKGEYVILD 176 Query: 146 EPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIIN 205 + ++V N ++LD+R R + E + Sbjct: 177 ADSHASIYDGCQQGNAEIVRFRHNSVEDLDKRLGRLPKEPAKLVVLEGVYS--------- 227 Query: 206 TPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLT 265 + L + + KH +++ DE + +F + + GQ+ Sbjct: 228 -------MLGDIAPLKEMVAVAKKHGAMVLVDEAHSMGFFGPNGRGVYEAQGLEGQIDFV 280 Query: 266 VGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGY 325 VG+ S G G+V+S + + + I AS P A A + L + Sbjct: 281 VGTFSASVGTVG---GFVVSNHPKFEAVRLACRPYIFTASLPPSVVATATTSIRKLMTAH 337 Query: 326 FEKMRQEYINKFKIFTSIFDELGLP 350 + R+ + + +G Sbjct: 338 --EKRERLWSNARALHGGLKAMGFR 360 >5VPR-A nrPDB Length = 414 Score = 55.6 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 66/441 (14%), Positives = 128/441 (29%), Gaps = 94/441 (21%) Query: 48 NSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSP 107 K G++L+ L S P+ + + N + + +++ Sbjct: 23 QEKVNGKDLVYLDNAATS-QKPKMVLDAINNYYEHYNANVHRGIHTLSQVATEMMEDARK 81 Query: 108 IYNTELKAE---NVTVTTGANEGILS---CLMGLLNAGDEVIVFEPFF-------DQYIP 154 + A+ V T G EGI + L+ DE+I+ + + Sbjct: 82 KVQRFINAKHDYEVLFTKGTTEGINLVAYAMTDLIKKDDEIII---SYLEHHSNIVPWQM 138 Query: 155 NIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKV 214 + G K+ +P+N E+ T+ + ++ ++ KTK V +N N +G V Sbjct: 139 LCQRTGAKLRVIPMN------------EDGTLQIDVLDEWLSEKTKLVSVNQVSNALGIV 186 Query: 215 FTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFA 274 +E+ + + K N I D + + S K + Sbjct: 187 NPIDEI--IRKVRAKSNAFIFID--------GAQAAPHFEIDVQTMDCDFFAFSGHKMYG 236 Query: 275 ATGWRIGWVLSLNAELLSYAAKAHT--------------------RICFASPSPLQEACA 314 TG I L A +L H R +P+ Sbjct: 237 PTGTGI---LYGKASVLEQLNPFHGGGEMIDHCTFEKTTYAGLPFRFEAGTPNIAGNIAI 293 Query: 315 NSINDALK------IGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEG--TYFVLVDFSK 366 + D ++ I E EY + + + GL + V + S Sbjct: 294 GTAVDFMEKVGRSNIAAHEHALLEYAQR-----KLLEIEGLKVYGEKANRAGVVSFNLSG 348 Query: 367 VKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAA-ENLLRFAVC- 424 + I D ++++LG+ E +R + Sbjct: 349 IGIASDVGM----------------ILDKLGIAVRTGHHCTQPIMEYFGVAGTVRASFAV 392 Query: 425 -KDDAYLENAVERLKLLKDYL 444 ++ E +K + L Sbjct: 393 YNTFEEIDILTEGVKKAQKML 413 >3TQX-A nrPDB Length = 399 Score = 55.6 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 49/382 (12%), Positives = 127/382 (33%), Gaps = 52/382 (13%) Query: 70 QFAIKEAQKALDIPMVNQYSPTRGRPSLI---NSLIKLYSPIYNTELKAENVTVTTGANE 126 IK AQ ++ QY I ++ K + L ++ + + + Sbjct: 60 PALIKTAQTVVE-----QYGFGMASVRFICGTQTIHKELEKDISEFLGTDDTILYSSCFD 114 Query: 127 GILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTI 186 LL D +I E I I LC + +N + Sbjct: 115 ANGGLFETLLGPEDAIISDELNHASIIDGIRLCKAQ----------RYRYKNNAMGDLEA 164 Query: 187 DFEQFEKAITSKTKAVIINTPHNPIGKVFTRE----ELTTLGNICVKHNVVIISDEVYEH 242 ++ ++ ++ K + VF+ + +L ++ ++ K+N +++ D+ + Sbjct: 165 KLKEADEK-GARFKLIA-------TDGVFSMDGIIADLKSICDLADKYNALVMVDDSHAV 216 Query: 243 LYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRIC 302 + ++ ++ + G+ GK+ G G+ + ++ + Sbjct: 217 GFIGENGRGTPEYCGVADRVDILTGTLGKALG--GASGGYTSGHKEIIEWLRNRSRPYLF 274 Query: 303 FASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLV 362 + +P+ A + + + LK ++R++ + F + ++LG Sbjct: 275 SNTVAPVIVATSLKVLELLKTEG-PQLRKQLQENSRYFRAGMEKLGFQL----------- 322 Query: 363 DFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFA 422 +P ++P +L + + + G+ + + + KA ++ + Sbjct: 323 ------VPGNHPIIPVMLGDAQLATNMADHLLQEGIYVV-GFSYPVVPMGKARIR-VQMS 374 Query: 423 VCKDDAYLENAVERLKLLKDYL 444 L+ A+E + L Sbjct: 375 AVHTQQQLDRAIEAFGQVGKKL 396 >6CJB-A nrPDB Length = 391 Score = 55.6 bits (132), Expect = 5e-08, Method: Composition-based stats. Identities = 31/148 (20%), Positives = 56/148 (37%), Gaps = 24/148 (16%) Query: 127 GILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTI 186 ++ ++ LL +GD V+ + +L GG + + + + Sbjct: 87 AAINTVIDLLGSGDHVVAMD----------DLYGGTFRLFDKVKTRTSNLSFSFIDMSV- 135 Query: 187 DFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFT 246 E E AIT KTK + + TP NP + L + I K+N++ ++D + T Sbjct: 136 -PENIEAAITPKTKLLWLETPSNP---MLKLANLRKIAAIAKKYNLITVADNTFA----T 187 Query: 247 DSFTRIATLSPEIGQLTLTVGSAGKSFA 274 R L + + + SA K Sbjct: 188 PWIQRPLELGFD-----IVLHSATKYLN 210 >3AEO-A nrPDB Length = 389 Score = 55.2 bits (131), Expect = 6e-08, Method: Composition-based stats. Identities = 61/361 (16%), Positives = 114/361 (31%), Gaps = 48/361 (13%) Query: 46 ANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDI----PMVNQYSPTRGRPSLINSL 101 +G +++ + + F Q+ D+ + YS G P ++ Sbjct: 8 TTLLHPKGDHVLH-SHAYPIFQTSTFCFDSTQQGADLFMGKGEGHIYSRL-GNP----TV 61 Query: 102 IKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGG 161 + + + E A + +G I S + L GD +I + + + Sbjct: 62 EQFEEMVCSIEGAAGSAAFGSG-MGAISSSTLAFLQKGDHLIAGDTLYGCTVSLF----- 115 Query: 162 KVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELT 221 ++P E+D +T D E+ + A TK V + +P NP KV ++ Sbjct: 116 -THWLP-RFGIEVDLIDTS------DVEKVKAAWKPNTKMVYLESPANPTCKV---SDIK 164 Query: 222 TLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRI- 280 + +C + ++ D +FT L P + + S K G I Sbjct: 165 GIAVVCHERGARLVVDA---------TFTSPCFLKPLELGADIALHSVSKYINGHGDVIG 215 Query: 281 GWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIF 340 G + AE ++ CA + ++ E K F Sbjct: 216 GVSSAKTAEDIATIKFYRKDAGSLMAPMDAFLCARGMKTLPIR---MQIHMENGLKVAKF 272 Query: 341 TSIFDELGLPYTAPEGTYFVLVDFSKVKIPED--YPYPEEILNKGKDFRISHWLINELGV 398 +++ + P L F I + Y L + K F + L+ L V Sbjct: 273 LEQHEKI-VKVNHPG-----LESFPGHDIAKKQMTGYGSTFLFEMKSFEAAKKLMEHLKV 326 Query: 399 V 399 Sbjct: 327 C 327 >3LVM-A nrPDB Length = 423 Score = 54.4 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 37/208 (17%), Positives = 67/208 (32%), Gaps = 36/208 (17%) Query: 98 INSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLN----AGDEVIVFEPFFDQYI 153 N + L + T+GA E + G N G +I + + Sbjct: 74 RNQIADL------VGADPREIVFTSGATESDNLAIKGAANFYQKKGKHIITSKTEHKAVL 127 Query: 154 PNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGK 213 + V P+ ID ++ E A+ T V I +N IG Sbjct: 128 DTCRQLEREGFEVTYLAPQR---------NGIIDLKELEAAMRDDTILVSIMHVNNEIGV 178 Query: 214 VFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAG--K 271 V +++ +G +C + +Y D+ + L ++ QL + + S K Sbjct: 179 V---QDIAAIGEMCRARGI----------IYHVDATQSVGKLPIDLSQLKVDLMSFSGHK 225 Query: 272 SFAATGWRIGWVLSLNAELLSYAAKAHT 299 + G IG + + A+ H Sbjct: 226 IYGPKG--IGALYVRRKPRVRIEAQMHG 251 >1T3I-A nrPDB Length = 420 Score = 54.0 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 42/242 (17%), Positives = 76/242 (31%), Gaps = 47/242 (19%) Query: 69 PQFAIKEAQKALDIPMVNQYS--------PTRGRPSLINSLIKLYSPIYNTELKAENVTV 120 P+ +++ + N + T ++ N + K + + Sbjct: 41 PRAVLEKLMHYYENDNANVHRGAHQLSVRATDAYEAVRNKVAKFINAR-----SPREIVY 95 Query: 121 TTGANEGILSC----LMGLLNAGDEVI---VFEPF-FDQYIPNIELCGGKVVYVPINPPK 172 T A E I M L AGDE+I + + G + +V ++ + Sbjct: 96 TRNATEAINLVAYSWGMNNLKAGDEIITTVMEHHSNLVPWQMVAAKTGAVLKFVQLDEQE 155 Query: 173 ELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNV 232 D E F+ ++ KTK V + N +G V EE + + + Sbjct: 156 SF------------DLEHFKTLLSEKTKLVTVVHISNTLGCVNPAEE---IAQLAHQAGA 200 Query: 233 VIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLS 292 ++ D L ++ V S K A TG IG++ E+L Sbjct: 201 KVLVDAC--------QSAPHYPLDVQLIDCDWLVASGHKMCAPTG--IGFLYG-KEEILE 249 Query: 293 YA 294 Sbjct: 250 AM 251 >1CS1-A nrPDB Length = 386 Score = 54.0 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 28/209 (13%), Positives = 64/209 (30%), Gaps = 42/209 (20%) Query: 119 TVTTGANEGILSCLMGLLNAGDEVIVFE----PFFDQYIPNIELCGGKVVYVPINPPKEL 174 +T I L GD ++ + + + +V++V Sbjct: 71 VLTNTGMSAIHLVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVD------- 123 Query: 175 DQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVI 234 D + A+ K K V++ +P NP+ +V ++ + ++ + V Sbjct: 124 ----------QGDEQALRAALAEKPKLVLVESPSNPLLRVV---DIAKICHLAREVGAVS 170 Query: 235 ISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFA-----ATGWRIGWVLSLNAE 289 + D ++F A +P L + S K G V++ + + Sbjct: 171 VVD---------NTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGV----VIAKDPD 217 Query: 290 LLSYAAKAHTRICFASPSPLQEACANSIN 318 +++ A I + + Sbjct: 218 VVTELAWWANNIGVTGGAFDSYLLLRGLR 246 >4JF0-A nrPDB Length = 422 Score = 53.7 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 65/413 (15%), Positives = 129/413 (31%), Gaps = 59/413 (14%) Query: 42 AAKAANNSKNQGRELINL--GQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLIN 99 K + QG+E I+ G + A+ EA K+ + + P+L Sbjct: 45 KGKGSRVWDQQGKEYIDFAGGIAVTALGHCHPALVEALKSQGETLWHTSRVFTNEPALR- 103 Query: 100 SLIKLYSPIYNTELKAENVTVTTGANEGILSCLM-------GLLNAGDEVIV-FEPFFDQ 151 AE V E + + I+ F F Sbjct: 104 -----LGRKLIDATFAERVLFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHG 158 Query: 152 YIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPI 211 GG+ Y PK D + D + + T AV++ Sbjct: 159 RSLFTVSVGGQPKYSDGFGPKPADIIHVPFN----DLHAVKAVMDDHTCAVVVEPIQGEG 214 Query: 212 G-KVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAG 270 G + T E L L ++C +H +++ DEV + T +T + ++ Sbjct: 215 GVQAATPEFLKGLRDLCDEHQALLVFDEVQCGMGRTGDLFAYMHYG-----VTPDILTSA 269 Query: 271 KSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACA--NSINDALKIGYFEK 328 K+ G+ + +L+ ++ +H +P A A + IN + Sbjct: 270 KALGG-GFPVSAMLTTQEIASAFHVGSHGSTYGGNPLACAVAGATFDIINTPEVLQGIHT 328 Query: 329 MRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRI 388 RQ+++ + FD + D + + + + +DF Sbjct: 329 KRQQFVQHLQAIDEQFD--------------IFSDIRGMGLLIGAELKPKYKGRARDFLY 374 Query: 389 SHWLINELGVVAIPPTEFYIKEHEKAAENLLRF--AVCKDDAYLENAVERLKL 439 + E GV+ + A +++RF ++ ++A + ++R Sbjct: 375 AGA---EAGVMVL-----------NAGADVMRFAPSLVVEEADIHEGMQRFAQ 413 >6HRH-B nrPDB Length = 469 Score = 53.3 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 49/316 (15%), Positives = 99/316 (31%), Gaps = 49/316 (15%) Query: 89 SPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLN--AGDEVIVFE 146 ++ L L +L+ ++ + + S L L G E+ Sbjct: 113 GTSKFHVELEQELAELHQK--------DSALLFSSCFVANDSTLFTLAKILPGCEIYSDA 164 Query: 147 PFFDQYIPNIELCGG-KVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSK-TKAVII 204 I I G K V+ +P ++ + K K V Sbjct: 165 GNHASMIQGIRNSGAAKFVFRHNDPDH---------------LKKLLEKSNPKIPKIVAF 209 Query: 205 NTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTL 264 T H+ G + L L ++ ++ + DEV+ + I + ++ + Sbjct: 210 ETVHSMDGAICP---LEELCDVSHQYGALTFVDEVHAVGLYGSRGAGIGERDGIMHKIDI 266 Query: 265 TVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIG 324 G+ GK+F G G++ S + + A I S P+ + A LK Sbjct: 267 ISGTLGKAFGCVG---GYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGE 323 Query: 325 YFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGK 384 + +R+ + K + + GLP + P + N Sbjct: 324 EGQALRRAHQRNVKHMRQLLMDRGLPVIPC----------------PSHIIPIRVGNAAL 367 Query: 385 DFRISHWLINELGVVA 400 + ++ L+++ G+ Sbjct: 368 NSKLCDLLLSKHGIYV 383 >5U24-A nrPDB Length = 382 Score = 53.3 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 23/130 (17%), Positives = 48/130 (36%), Gaps = 21/130 (16%) Query: 118 VTVTTGANEGILSCLMGL-LNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQ 176 + V G + + + DE+IV + I I K + + Sbjct: 75 IGVANG-LDALRLIIKAYDFKENDEIIVPANTYIASILAITDNKCKPILI---------- 123 Query: 177 RNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIIS 236 + I+ + E+ IT KTKA+++ + ++ + + K+N+ II Sbjct: 124 -EPDINTYNINPDLIEEKITKKTKAIMV------VHLYGQVCDMEKIQLLANKYNLKIIE 176 Query: 237 D--EVYEHLY 244 D + + +Y Sbjct: 177 DCAQAHGAIY 186 >5TSU-A nrPDB Length = 422 Score = 53.3 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 34/153 (22%), Positives = 57/153 (37%), Gaps = 34/153 (22%) Query: 127 GILSCLMGLLNAGDEVIVFEPFFDQ----YIPNIELCGGKVVYVPINPPKELDQRNTRGE 182 + LL AGD++I + + + G K+ +V + K Sbjct: 109 AATVTITHLLKAGDQIICMDDVYGGTNLYFRQVASEFGLKISFVDCSKIKL--------- 159 Query: 183 EWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKH-NVVIISDEVYE 241 E AIT +TK V I TP NP KV E + + KH +++++ D Sbjct: 160 --------LEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVH---KHGDIILVVDN--- 205 Query: 242 HLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFA 274 + + F R L + +++ SA K Sbjct: 206 -TFMSPYFQRPLALGAD-----ISMYSATKYMN 232 >5VMB-A nrPDB Length = 425 Score = 52.9 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 41/298 (13%), Positives = 84/298 (28%), Gaps = 25/298 (8%) Query: 83 PMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEV 142 P Y + I ++ + NV G+ + + + LLN GD V Sbjct: 67 PGKRYYGGCEFVDVIEQMAIDRAKELFGADYA--NVQPHAGS-QANSAVYLALLNPGDTV 123 Query: 143 IVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAV 202 + ++ G KV + N E ID+E+ E+ + Sbjct: 124 LGMSLAHGGHLT----HGAKVSFSGKTYNAVQYGLNA--ETGEIDYEEVERLALEHKPRM 177 Query: 203 IINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVY-EHLYFTDSFTRIATLSPEIGQ 261 I+ + +I K + D + L + ++ Sbjct: 178 IVAGFS----AYSRVVDWQRFRDIADKVGAYLFVDMAHVAGLVAAGVYPNPVQIADVTTT 233 Query: 262 LTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANS-INDA 320 T K+ G R G +L+ E + ++ + A + Sbjct: 234 TTH------KTLR--GPRSGLILAKANEEIEKKLQSAVFPGNQGGPLMHAIAAKAICFKE 285 Query: 321 LKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAP--EGTYFVLVDFSKVKIPEDYPYP 376 F+ +Q+ + + +F G + + F+L + +D Sbjct: 286 AMSDDFKAYQQQVVKNAQAMAEVFIARGYDVVSGGTDNHLFLLSLIKQDVTGKDADAW 343 >2E7J-A nrPDB Length = 371 Score = 52.9 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 45/263 (17%), Positives = 89/263 (33%), Gaps = 31/263 (11%) Query: 95 PSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIP 154 P + + + ++ VT GA E + + L V++ E Sbjct: 53 PPIHDFIHNQLPKFLGCDVAR----VTNGAREAKFAVMHSLAKKDAWVVMDENCHYSSYV 108 Query: 155 NIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKA--VIINTPHNPIG 212 E G + VP T ++ I E F + I K V++ P G Sbjct: 109 AAERAGLNIALVP----------KTDYPDYAITPENFAQTIEETKKRGEVVLALITYPDG 158 Query: 213 KVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKS 272 ++ + +C +++V ++ + Y + + + VGS KS Sbjct: 159 NYGNLPDVKKIAKVCSEYDVPLLVNGAYA---IGRMPVSLKEIGADF-----IVGSGHKS 210 Query: 273 FAATGWRIGWVLSLNAE----LLSYAAKAHTR-ICFASPSPLQEACANSINDALKIGYFE 327 AA+G IG V+ + E +L + K + + + + + Sbjct: 211 MAASGP-IG-VMGMKEEWAEIVLRRSEKYKNKEVELLGCTARGATIITLMASFPHVRERI 268 Query: 328 KMRQEYINKFKIFTSIFDELGLP 350 K E + K + F + ++LG+ Sbjct: 269 KRWDEEVEKARRFAAEMEKLGIK 291 >4IYO-A nrPDB Length = 397 Score = 52.9 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 40/183 (21%), Positives = 62/183 (33%), Gaps = 36/183 (19%) Query: 127 GILSCLMGLLNAGDEVIVFEPFFDQYIPNI-----ELCGGKVVYVPINPPKELDQRNTRG 181 S +M LL+AG V+ + + G +V + Sbjct: 90 AATSTVMELLDAGSHVVAMDDLYGGTFRLFERVRRRTAGLDFSFVDLT------------ 137 Query: 182 EEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYE 241 D F+ AI + TK V I TP NP + ++ + I KH ++ + D + Sbjct: 138 -----DPAAFKAAIRADTKMVWIETPTNP---MLKLVDIAAIAVIARKHGLLTVVDNTFA 189 Query: 242 HLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIG--WVLSLNAELLSYAAKAHT 299 + R +L + L V SA K +G V+ NAEL A Sbjct: 190 ----SPMLQRPLSLGAD-----LVVHSATKYLNGHSDMVGGIAVVGDNAELAEQMAFLQN 240 Query: 300 RIC 302 I Sbjct: 241 SIG 243 >5WGB-A nrPDB Length = 426 Score = 52.5 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 39/266 (14%), Positives = 78/266 (29%), Gaps = 50/266 (18%) Query: 82 IPMVNQYSPT--RGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMG---LL 136 + Y + L + T+GA E + G Sbjct: 58 HSRTHAYGWESEAAMERARQQVASLIGA------DPREIIFTSGATESNNIAIKGVARFY 111 Query: 137 NAGDEVIVFEPF----FDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFE 192 + + ++ ++E G +V Y+P+ ID ++ E Sbjct: 112 RSRKKHLITTQTEHKCVLDSCRSLEAEGFQVTYLPVQKSGI------------IDLKELE 159 Query: 193 KAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRI 252 AI T V + T +N IG ++ + +G IC V +D + Sbjct: 160 AAIQPDTSLVSVMTVNNEIGV---KQPIAEIGRICSSRKVYFHTDAA----------QAV 206 Query: 253 ATLSPEIGQLTLTVGSAG--KSFAATGWRIGWVLSLN------AELLSYAAKAHTRICFA 304 + ++ + + + S K + G +G + L S + Sbjct: 207 GKIPLDVNDMKIDLMSISGHKIYGPKG--VGAIYIRRRPRVRVEALQSGGGQERGMRSGT 264 Query: 305 SPSPLQEACANSINDALKIGYFEKMR 330 P+PL + A + ++ R Sbjct: 265 VPTPLVVGLGAACEVAQQEMEYDHKR 290 >5DX5-A nrPDB Length = 400 Score = 52.5 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 59/353 (16%), Positives = 116/353 (32%), Gaps = 61/353 (17%) Query: 116 ENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIEL----CGGKVVYVPINPP 171 E V I + L L +GD V+ + + + G +V +V ++ Sbjct: 80 EAAVVAASGMGAIAASLWSALKSGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVDVS-- 137 Query: 172 KELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHN 231 + ++ + A+ TK V + TP NP KV +++ + + K Sbjct: 138 ---------------NLDEVKNALKPNTKVVYLETPANPTLKVTDIRKISNMVHESNKEC 182 Query: 232 VVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFA-----ATGWRIG---WV 283 V + D + T R L + + V SA K G+ +G ++ Sbjct: 183 FVFV-DNTFC----TPYIQRPLELGAD-----VVVHSATKYLNGHGDVIAGFAVGKEEFI 232 Query: 284 -----LSLNAELLSYAAKAHTRICFASPSPLQ----EACANSINDALKIGYFEKMRQEY- 333 + S + + LQ + C N++ A + + + Y Sbjct: 233 NQVKLFGIKDMTGSVTGPFESFLIIRGMKTLQLRMEKHCKNAMEVAKFLESHPAVEKVYY 292 Query: 334 --INKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHW 391 + FK + +++ LP G V+ + ++ S Sbjct: 293 PGLESFKYYQLAREQMKLP-----GAMISFELKGGVEEGKIVMNNVKLATLAVSLGDSET 347 Query: 392 LINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLKDYL 444 LI + P ++ ++ L+R +V LE+A + + LK L Sbjct: 348 LIQHPASMTHSPYTAEERKAAGISDGLVRLSVG-----LEDAEDIIDDLKQAL 395 >1E5F-A nrPDB Length = 404 Score = 52.5 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 57/339 (16%), Positives = 110/339 (32%), Gaps = 55/339 (16%) Query: 114 KAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKE 173 K E T+ I + ++ +L AGD +I E + E K + Sbjct: 76 KTEACVATSSGMGAIAATVLTILKAGDHLISDECLYGCTHALFEHALTKF-------GIQ 128 Query: 174 LDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVV 233 +D NT + +K + TK V TP NP K+ E + + + V+ Sbjct: 129 VDFINTAI------PGEVKKHMKPNTKIVYFETPANPTLKIIDMERVCK--DAHSQEGVL 180 Query: 234 IISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFA-----ATGWRIGWVLSLNA 288 +I+D ++F +P + + V SA K G G A Sbjct: 181 VIAD---------NTFCSPMITNPVDFGVDVVVHSATKYINGHTDVVAGLICG-----KA 226 Query: 289 ELLSYAAKAHTRICFASPSPLQEA-----CANSINDALKIGY-----FEKMRQEYINKFK 338 +LL + S +A +++N +K + + + K Sbjct: 227 DLLQQIRMVGIKDITGSVISPHDAWLITRGLSTLNIRMKAESENAMKVAEYLKSHPAVEK 286 Query: 339 IFTSIFDEL-GLPYTAPE----GTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLI 393 ++ F++ G + G+ + S + + +++ LI Sbjct: 287 VYYPGFEDHEGHDIAKKQMRMYGSMITFILKSGFEGAKKLLDNLKLITLAVSLGGCESLI 346 Query: 394 NELGV---VAIPPTEFYIKEHEKAAENLLRFAVCKDDAY 429 +P E +E + ++R +V +DA Sbjct: 347 QHPASMTHAVVPKEE---REAAGITDGMIRLSVGIEDAD 382 >6ONN-A nrPDB Length = 402 Score = 52.1 bits (123), Expect = 5e-07, Method: Composition-based stats. Identities = 31/257 (12%), Positives = 69/257 (26%), Gaps = 32/257 (12%) Query: 94 RPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYI 153 L + L + + + +TG L+ L L G + D Sbjct: 94 HAQLEDDLAEFAGGFVD---NPRALYFSTG-YMANLATLTALAGRGTTLFS-----DSLN 144 Query: 154 PNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGK 213 + G ++ I D +A + K ++ Sbjct: 145 HASLIDGARLSRADIQIYPHADAEA---------LGAMLEASDAAVKLIV-------SDT 188 Query: 214 VFTREE----LTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSA 269 VF+ + L L + H ++ D+ + + + VG+ Sbjct: 189 VFSMDGDIAPLARLLELAEHHGAWLVVDDAHGFGVLGPQGRGAVAEAALRSPHLIVVGTL 248 Query: 270 GKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKM 329 GK+ +G +V++ + +A I + P ++ + E Sbjct: 249 GKAAGVSG---AFVVAHETVIEWLVQRARPYIFTTASVPSAAHAVSASLRIIGGDEGEHR 305 Query: 330 RQEYINKFKIFTSIFDE 346 R + + + Sbjct: 306 RAHLRSLIALTRDMLKS 322 >4Q6R-A nrPDB Length = 511 Score = 51.7 bits (122), Expect = 7e-07, Method: Composition-based stats. Identities = 24/132 (18%), Positives = 46/132 (34%), Gaps = 22/132 (16%) Query: 119 TVTTGANEGILSCLMGLLN-------AGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPP 171 VT+G E IL + E++ + + G K+V VP+ Sbjct: 148 CVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQSAHAAFNKAASYFGMKIVRVPLTKM 207 Query: 172 KELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHN 231 E +D +AI+ T ++ +TP P G + + + + + VK+ Sbjct: 208 ME------------VDVRAMRRAISRNTAMLVCSTPQFPHGVI---DPVPEVAKLAVKYK 252 Query: 232 VVIISDEVYEHL 243 + + D Sbjct: 253 IPLHVDACLGGF 264 >4ADC-A nrPDB Length = 406 Score = 51.7 bits (122), Expect = 7e-07, Method: Composition-based stats. Identities = 65/412 (15%), Positives = 130/412 (31%), Gaps = 51/412 (12%) Query: 44 KAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIK 103 + + QG+E I+ G + + A E ++AL+ + G + +++ Sbjct: 29 EGSRLWDQQGKEYIDFAGGI-AVNALGHAHPELREALNEQASKFWHTGNGYTN--EPVLR 85 Query: 104 LYSPIYNTELKAENVTVTTGANEGILSCLM--------GLLNAGDEVIVFEPFFDQYIPN 155 L + + A+ V E + L + ++ F+ F Sbjct: 86 LAKKLIDATF-ADRVFFCNSGAEANEAALKLARKFAHDRYGSHKSGIVAFKNAFHGRTLF 144 Query: 156 IELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKV- 214 GG+ Y P D R+ D I T AVI+ G V Sbjct: 145 TVSAGGQPAYSQDFAPLPADIRHAAYN----DINSASALIDDSTCAVIVEPIQGEGGVVP 200 Query: 215 FTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFA 274 + L L +C +HN ++I DEV + T +T + + K+ Sbjct: 201 ASNAFLQGLRELCNRHNALLIFDEVQTGVGRTGELYAYMHYG-----VTPDLLTTAKALG 255 Query: 275 ATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYI 334 G+ +G +L+ E + T +PL A A L++ +M Sbjct: 256 G-GFPVGALLAT--EECARVMTVGTHGTTYGGNPLASAVA---GKVLELINTPEMLNGVK 309 Query: 335 NKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLIN 394 + F + + Y + + + + + + K Sbjct: 310 QRHDWFVERLNTINHRYG-------LFSEVRGLGLLIGCVLNADYAGQAKQISQEAA--- 359 Query: 395 ELGVVAIPPTEFYIKEHEKAAENLLRFAVCKD--DAYLENAVERLKLLKDYL 444 + GV+ + A N++RFA + + + ++R ++ Sbjct: 360 KAGVMVL-----------IAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHF 400 >1N8P-A nrPDB Length = 393 Score = 51.3 bits (121), Expect = 8e-07, Method: Composition-based stats. Identities = 44/277 (15%), Positives = 84/277 (30%), Gaps = 39/277 (14%) Query: 188 FEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKH----NVVIISDEVYEHL 243 + I TK V I TP NP ++ + ++ KH +V+++ D Sbjct: 128 LNDLPQLIKENTKLVWIETPTNPT---LKVTDIQKVADLIKKHAAGQDVILVVD------ 178 Query: 244 YFTDSFTRIATLSPEIGQLTLTVGSAGKSFAA-TGWRIGWVLSLNAELLSYAAKAHTRIC 302 ++F +P + V SA K + +G + + N L I Sbjct: 179 ---NTFLSPYISNPLNFGADIVVHSATKYINGHSDVVLGVLATNNKPLYERLQFLQNAIG 235 Query: 303 FASPSPL----QEACANSINDALKIGYFEKMR-QEYINKFKIFTSIFDELGLPYTAPE-- 355 PSP +++ ++ + E++ K + GL T P Sbjct: 236 A-IPSPFDAWLTHRGLKTLHLRVRQAALSANKIAEFLAADKENVVAVNYPGLK-THPNYD 293 Query: 356 -----------GTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPT 404 G + + + + L+ V+ Sbjct: 294 VVLKQHRDALGGGMISFRIKGGAEAASKFASSTRLFTLAESLGGIESLLEVPAVMTHGGI 353 Query: 405 EFYIKEHEKAAENLLRFAVC--KDDAYLENAVERLKL 439 +E ++L+R +V D LE+ + LK Sbjct: 354 PKEAREASGVFDDLVRISVGIEDTDDLLEDIKQALKQ 390 >5X5H-A nrPDB Length = 392 Score = 51.0 bits (120), Expect = 9e-07, Method: Composition-based stats. Identities = 53/409 (12%), Positives = 115/409 (28%), Gaps = 59/409 (14%) Query: 51 NQGRELINLGQG-FFS-----YSPPQFAIKEAQKALDIPMVNQYSPTR-GRP---SLINS 100 QG ++ G + P +A + + Y TR G P +L + Sbjct: 7 TQGFSTASIHAGYEPDDYYGSINTPIYASTTFAQNAPNELRKGYEYTRVGNPTIVALEQT 66 Query: 101 LIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCG 160 + L Y + +L GD +++ + I+ Sbjct: 67 VAALEGAKYGRAFSS--------GMAATDILFRIILKPGDHIVLGNDAYGGTYRLID--- 115 Query: 161 GKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREEL 220 V+ + + E+ + AI TK + + TP NP ++ Sbjct: 116 --TVFTAWGVEYTVVDTSV--------VEEVKAAIKDNTKLIWVETPTNP---ALGITDI 162 Query: 221 TTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRI 280 + + N ++ D ++F P + S K + Sbjct: 163 EAVAKLTEGTNAKLVVD---------NTFASPYLQQPLKLGAHAVLHSTTKYIGGHSDVV 213 Query: 281 GWVLSLNAELLSYAAKAHTRICFASPSPLQE------ACANSINDALKIGYFEKMRQEYI 334 G ++ N + + PS ++ EK+ + Sbjct: 214 GGLVVTNDQEMDEELLFMQGGIGPIPSVFDAYLTARGLKTLAVRMDRHCDNAEKIAEFLD 273 Query: 335 NKFK----IFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISH 390 ++ + ++ + + G A + V+ ++ K ++ Sbjct: 274 SRPEVSTVLYPGLKNHPGHEVAAKQ--MKRFGGMISVRFAGGEEAAKKFCTSTKLICLAE 331 Query: 391 WLINELGVVAIPPTEFYIKEHEKAAE---NLLRFAV-CKDDAYLENAVE 435 L ++ P T + E +L+R ++ +D L VE Sbjct: 332 SLGGVESLLEHPATMTHQSAAGSQLEVPRDLVRISIGIEDIEDLLADVE 380 >4QGR-A nrPDB Length = 382 Score = 51.0 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 27/143 (18%), Positives = 47/143 (32%), Gaps = 25/143 (17%) Query: 105 YSPIYNTELKAENVTVTTGANEGILSCLMGL-LNAGDEVIVFEPFFDQYIPNIELCGGKV 163 + L E+V + + LM + G V V F + L G + Sbjct: 47 FEKKLGEYLGVEHVIACANGTDALQMPLMTRGIGPGHAVFVPSFTFAATAEVVALVGAEP 106 Query: 164 VYVPINPPKELDQRNTRGEEWTIDFEQFEKAITS-------KTKAVIINTPHNPIGKVFT 216 V+V ++P + ++ EQ E AI + + KA+I P+ Sbjct: 107 VFVDVDPDS-----------YNMNVEQLEAAIAATIKEGRLEPKAII------PVDLFGL 149 Query: 217 REELTTLGNICVKHNVVIISDEV 239 + I + + II D Sbjct: 150 AASYNRITAIAEREGLFIIEDAA 172 >2EZ1-A nrPDB Length = 456 Score = 51.0 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 56/373 (15%), Positives = 119/373 (31%), Gaps = 36/373 (9%) Query: 88 YSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEP 147 Y+ + L ++ +L+ + + T + G V Sbjct: 71 YAGSENFYHLERTVQELFGFKH--------IVPTHQGRGAENLLSQLAIKPGQYVAGNM- 121 Query: 148 FFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSK----TKAVI 203 +F + E G V+V I + D + ID ++ +K I K + Sbjct: 122 YFTTTRYHQEKNGA--VFVDIVRDEAHDAGLNIAFKGDIDLKKLQKLIDEKGAENIAYIC 179 Query: 204 I-NTPHNPIGKVFTREELTTLGNICVKHNVVIISDE--VYEHLYFTDSFTRIATLSPEIG 260 + T + G+ + + + + H + + D E+ YF + I Sbjct: 180 LAVTVNLAGGQPVSMANMRAVRELTEAHGIKVFYDATRCVENAYFIKE-QEQGFENKSIA 238 Query: 261 QLTLTVGSAGKSFAATGWR------IGWVLSLNAELLSYAAKAHTRICFASPSPLQEACA 314 ++ + S +G + G++ + E+ S A + + PS A Sbjct: 239 EIVHEMFSYADGCTMSGKKDCLVNIGGFLCMNDDEMFSSAKELVV-VYEGMPSYGGLAGR 297 Query: 315 NSINDALKIGYFEKMRQEYINKF----KIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIP 370 + +A+ IG E M+ EYI + G+P P G + V +D + Sbjct: 298 DM--EAMAIGLREAMQYEYIEHRVKQVRYLGDKLKAAGVPIVEPVGGHAVFLDARRFCEH 355 Query: 371 EDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCK---DD 427 + + E G+++ EH + +R + + Sbjct: 356 LTQDEFPAQSLAASIYVETGVRSMERGIISA-GRNNVTGEHHRPKLETVRLTIPRRVYTY 414 Query: 428 AYLENAVERLKLL 440 A+++ + + L Sbjct: 415 AHMDVVADGIIKL 427 >5YKR-A nrPDB Length = 461 Score = 50.6 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 72/426 (16%), Positives = 136/426 (31%), Gaps = 42/426 (9%) Query: 3 QRFIRQFTNLMSTSRPKVVANK----YFTSNTAKDVWSLTNEAAAKAANNSKNQ---GRE 55 +R +R+F L S N+ Y W K A ++ G++ Sbjct: 17 KRELRRFDELHPRSAQAYRENRRHWLYGAPLHWMQQWPGNCPLLVKEAQGARVTDIDGQQ 76 Query: 56 LINLGQGFFS--YSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTEL 113 ++ G + Q A+ +A PT + L + + Y Sbjct: 77 YVDFALGDSGAMFGHAQPAVADAIARQARRGSTLMLPTEDSLWVGAELARRFGLPYWQ-- 134 Query: 114 KAENVTVTTGANEGILSCLM--GLLNAGDEVIVFEPFFDQYIPN----IELCGGKVVYVP 167 VTT A + L +L+ D+V+VF + + + G V Sbjct: 135 ------VTTSATDANRFVLRLCRMLSGRDKVVVFNCNYHGSVDESQVEFDAAGRMVPRAG 188 Query: 168 INPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTP--HNPIGKVFTREELTT-LG 224 ++P TR E+ D + E A+ A ++ P N +G V E L Sbjct: 189 VHPNGVRHATTTRLVEFN-DLDALEAALAHGDVAAVLTEPFMTN-VGMVPPAEGFHAGLR 246 Query: 225 NICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQL--TLTVGSAGKSFAAT---GWR 279 + +H+V +I DE + ++ L P+ L + G + + R Sbjct: 247 ELTRRHDVALIIDETHTISCGPAGYSGAHGLEPDFFVLGKCIAGGIPSAVWGCSQAQAER 306 Query: 280 IGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKI 339 I W + + A + A + + + + M Q Sbjct: 307 I-WAVLPHFRPGQAINHFGFGGTLAGNALQLAAMRATFAEVMTEDAYRHMFQLAAQLEAG 365 Query: 340 FTSIFDELGLPYTAPE-GTY--FVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINEL 396 + +EL LP+ G ++ + + E + ++ + +L+N Sbjct: 366 VRATLEELRLPWHVTRIGARVEYLFMTHAPRNGGEAHHARNGLIEA----CLHLYLLNR- 420 Query: 397 GVVAIP 402 GV+ P Sbjct: 421 GVLLTP 426 >1C7G-A nrPDB Length = 456 Score = 50.6 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 55/328 (16%), Positives = 101/328 (30%), Gaps = 30/328 (9%) Query: 88 YSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEP 147 Y+ + L ++ +L+ + + T + G V Sbjct: 71 YAGSENFYHLEKTVKELFGFKH--------IVPTHQGRGAENLLSQLAIKPGQYVAGNM- 121 Query: 148 FFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSK----TKAVI 203 +F + E G +V I + D + ID + I K + Sbjct: 122 YFTTTRFHQEKNGA--TFVDIVRDEAHDASLNLPFKGDIDLNKLATLIKEKGAENIAYIC 179 Query: 204 I-NTPHNPIGKVFTREELTTLGNICVKHNVVIISDE--VYEHLYFTDSFTRIATLSPEIG 260 + T + G+ + + + + + + I D E+ YF + I Sbjct: 180 LAVTVNLAGGQPVSMANMRAVHEMASTYGIKIFYDATRCVENAYFIKE-QEAGYENVSIK 238 Query: 261 QLTLTVGSAGKSFAATGWR-----IGWVLSLNAELLSYAAKAHTRICFASPSPLQEACAN 315 + + S +G + IG L +N E + AAK + PS A + Sbjct: 239 DIVHEMFSYADGCTMSGKKDCLVNIGGFLCMNDEEMFSAAKELVVVYEGMPSYGGLAGRD 298 Query: 316 SINDALKIGYFEKMRQEYINKF----KIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPE 371 +A+ IG E M+ EYI + E G+P P G + V +D + Sbjct: 299 M--EAMAIGLREAMQYEYIEHRVKQVRYLGDKLREAGVPIVEPTGGHAVFLDARRFCPHL 356 Query: 372 DYPYPEEILNKGKDFRISHWLINELGVV 399 + + E G+V Sbjct: 357 TQDQFPAQSLAASIYMETGVRSMERGIV 384 >4L0O-H nrPDB Length = 388 Score = 50.6 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 33/177 (18%), Positives = 61/177 (34%), Gaps = 29/177 (16%) Query: 74 KEAQKALDIPMVNQYSPTRGRP---SLINSLIKLYSPIYNTELKAENVTVTTGANEGILS 130 Q A+ +YS + G P +L + L + +G + Sbjct: 30 TYRQDAIGRHKGYEYSRS-GNPTRFALEELIADLEGGVKGF-------AFASG--LAGIH 79 Query: 131 CLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQ 190 + LL +GD V++ + + V V + + D Q Sbjct: 80 AVFSLLQSGDHVLLGDDVYGGTFRLFNQ-----VLVKNGLSCTIIDTS--------DISQ 126 Query: 191 FEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTD 247 +KAI TKA+ + TP NP+ +L ++ H ++ I D + Y+ + Sbjct: 127 IKKAIKPNTKALYLETPSNPL---LKITDLAQCASVAKDHGLLTIVDNTFATPYYQN 180 >3WGB-A nrPDB Length = 341 Score = 49.8 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 36/269 (13%), Positives = 78/269 (28%), Gaps = 34/269 (12%) Query: 88 YSPTRGRPSLINSLIKLYSPIYNTEL-KAENVTVTTGANEGILSCLMGLLNAGDEVIVF- 145 Y G +L Y +L E L +M G+ ++ Sbjct: 35 YGEDPGVNAL---------EAYGADLLGKEAALFVPSGTMSNLLAVMSHCQRGEGAVLGS 85 Query: 146 -EPFFD-QYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVI 203 + + + L + VP+ L + R D T T+ V Sbjct: 86 AAHIYRYEAQGSAVLGSVALQPVPMQADGSLALADVRAAIAPDDVH-----FTP-TRLVC 139 Query: 204 INTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLT 263 + HN GKV L + + +H + + D S + L ++ Sbjct: 140 LENTHN--GKVLPLPYLREMRELVDEHGLQLHLDGARLFNAVVASGHTVRELVAPFDSVS 197 Query: 264 LTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRI--CFASPSPLQEACANSINDAL 321 + K A +G +L + ++ A + + L +A ++ Sbjct: 198 IC---LSKGLGAP---VGSLLVGSHAFIARARRLRKMVGGGMRQAGILAQAGLFALQQ-- 249 Query: 322 KIGYFEKMRQEYINKFKIFTSIFDELGLP 350 + ++ ++ ++ + G+ Sbjct: 250 ---HVVRLADDHRRARQLAEGLAALPGIR 275 >1FC4-A nrPDB Length = 401 Score = 49.8 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 63/451 (13%), Positives = 142/451 (31%), Gaps = 64/451 (14%) Query: 1 MKQRFIRQFTNLMSTSRPKVVANKYFTSNTAKDVWSLTNEAAAKAANNSKNQGRELINLG 60 M+ F +Q TN + T+R + + +A+ A+ + G +IN Sbjct: 4 MRGEFYQQLTNDLETARAEGL------------FKEERIITSAQQADITVADGSHVINFC 51 Query: 61 QGFF-SYSPPQFAIKEAQKALDIPMVNQYSPTR--GRPSLINSLIKLYSPIYNTELKAEN 117 + + I A+ +D S G L + + E+ Sbjct: 52 ANNYLGLANHPDLIAAAKAGMDSHGFGMASVRFICGTQDSHKELEQKLAAFLGM----ED 107 Query: 118 VTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQR 177 + + + LL A D +I I + LC K N +EL+ R Sbjct: 108 AILYSSCFDANGGLFETLLGAEDAIISDALNHASIIDGVRLCKAKRYRYANNDMQELEAR 167 Query: 178 NTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTRE----ELTTLGNICVKHNVV 233 ++A + + V+I VF+ + L + ++ K++ + Sbjct: 168 -------------LKEAREAGARHVLIA-----TDGVFSMDGVIANLKGVCDLADKYDAL 209 Query: 234 IISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSY 293 ++ D+ + + ++ +G++ + G+ GK+ G G+ + + Sbjct: 210 VMVDDSHAVGFVGENGRGSHEYCDVMGRVDIITGTLGKALG--GASGGYTAARKEVVEWL 267 Query: 294 AAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTA 353 ++ + S +P A + + + ++ G ++R + F G Sbjct: 268 RQRSRPYLFSNSLAPAIVAASIKVLEMVEAGS--ELRDRLWANARQFREQMSAAGF---- 321 Query: 354 PEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEK 413 + + P + + + + L + G+ FY + Sbjct: 322 ------------TLAGADHAIIPVMLGDAVVAQKFAREL-QKEGIYVT--GFFYPVVPKG 366 Query: 414 AAENLLRFAVCKDDAYLENAVERLKLLKDYL 444 A + + + AVE + L Sbjct: 367 QARIRTQMSAAHTPEQITRAVEAFTRIGKQL 397 >2CTZ-A nrPDB Length = 421 Score = 49.4 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 49/364 (13%), Positives = 97/364 (26%), Gaps = 51/364 (14%) Query: 59 LGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENV 118 L + Y + K + A ++ + ++ ++N + + + Sbjct: 19 LSRQVPIYPTTSYVFKSPEHAANLFALKEFGNI--YSRIMNPTVDVLEKRLAALEGGKAA 76 Query: 119 TVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRN 178 T + L L AGD ++ + + V + + Sbjct: 77 LATASGHAAQFLALTTLAQAGDNIVSTPNLYGGTFNQFK--------VTLKRLGIEVRFT 128 Query: 179 TRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDE 238 +R E E+F KT+A + + NP +L L + V +I D Sbjct: 129 SREER----PEEFLALTDEKTRAWWVESIGNP---ALNIPDLEALAQAAREKGVALIVDN 181 Query: 239 VYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAH 298 + + L P L S K WV A + Sbjct: 182 TFGMGGY--------LLRPLAWGAALVTHSLTK----------WVGGHGAVIAGAIVDGG 223 Query: 299 TRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTY 358 PL + F ++ + LG P + Sbjct: 224 NFPWEGGRYPLLTEPQPGYHGLRLTEAFGELAFIVKARVDGLRDQGQALG-----PFEAW 278 Query: 359 FVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAI--PPTEFYIKEHEKAAE 416 VL+ + + + + ++HWL+ + V + P H A+ Sbjct: 279 VVLLGMETLSLRAERHVENTLH-------LAHWLLEQPQVAWVNYPGLP--HHPHHDRAQ 329 Query: 417 NLLR 420 + Sbjct: 330 KYFK 333 >5JAY-A nrPDB Length = 402 Score = 49.0 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 38/353 (10%), Positives = 92/353 (26%), Gaps = 55/353 (15%) Query: 94 RPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYI 153 L + L + A + +TG L+ L L G + D Sbjct: 94 HAQLEDDLAEFVGGFVE---NARALYFSTG-YMANLATLTALAGRGTTLFS-----DALN 144 Query: 154 PNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGK 213 + G ++ + D +A + K ++ Sbjct: 145 HASLIDGARLSRADVQIYPHCDTDA---------LSAMLEASDADVKVIV-------SDT 188 Query: 214 VFTREE----LTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSA 269 VF+ + L L + +H +I D+ + + +++G+ Sbjct: 189 VFSMDGDIAPLPRLLELAEQHGAWLIVDDAHGFGVLGPQGRGAIAQAALRSPNLISIGTL 248 Query: 270 GKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKM 329 K+ +G +V + + +A I + P ++ + + Sbjct: 249 DKAAGVSG---AFVAAHETVIEWLVQRARPYIFTTASVPAAAHAVSASLRIIGGEEGDAR 305 Query: 330 RQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRIS 389 R ++ P+ + + + ++ D + Sbjct: 306 RAHLQQLIGRTRAMLKAT--PWLP----------------VDSHTAVQPLIIGANDATLE 347 Query: 390 HWLINELGVVAIPPTEFYIKEHEKAAENLLRFAV--CKDDAYLENAVERLKLL 440 + + +P + LR ++ A L+ L+ L Sbjct: 348 IAATLDRAGLWVPAIR---PPTVPTGTSRLRISLSAAHSQADLDRLEAGLQQL 397 >3MAF-B nrPDB Length = 518 Score = 48.7 bits (114), Expect = 6e-06, Method: Composition-based stats. Identities = 27/159 (16%), Positives = 48/159 (30%), Gaps = 24/159 (15%) Query: 120 VTTGANEGILSCLMGLLNAGD--------EVIVFEPFFDQYIPNIELCGGKVVYVPINPP 171 VT+G E +L + + E +V + + G K+V P++ Sbjct: 169 VTSGGTESLLLAMKTYRDWARATKGITAPEAVVPVSAHAAFDKAAQYFGIKLVRTPLDA- 227 Query: 172 KELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHN 231 ++ D +AIT T V + P P G V + + + + +H Sbjct: 228 -----------DYRADVAAMREAITPNTVVVAGSAPGYPHGVV---DPIPEIAALAAEHG 273 Query: 232 VVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAG 270 + D R+ P V S Sbjct: 274 IGCHVDACLGGFIL-PWAERLGYPVPPFDFRLEGVTSVS 311 >5I92-A nrPDB Length = 435 Score = 48.3 bits (113), Expect = 8e-06, Method: Composition-based stats. Identities = 51/310 (16%), Positives = 92/310 (29%), Gaps = 44/310 (14%) Query: 119 TVTTGANEGILSCLMGLLNAG----DEVIVFEPFFDQYIPNIEL---CGGKVVYVPINPP 171 V++G E +S + L G D +I FE + + ++ + G VP +P Sbjct: 119 MVSSG-TEATMSAIR--LARGYTGRDSIIKFEGCYHGHSDSLLVKAGSGALTFGVPNSPG 175 Query: 172 KELDQRNTRGEEWTIDFEQFEKAITS---KTKAVIINTPHNPIGKVFT-----REELTTL 223 D E K + + +I+ P+ L L Sbjct: 176 VPAAFAKHTLTLPFNDIEAVRKTLGEVGKEVACIIVE----PVAGNMNCVPPAPGFLEGL 231 Query: 224 GNICVKHNVVIISDEVYEHL-YFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGW 282 C +H VV+I DEV ++P+ + + GK G +G Sbjct: 232 REACDEHGVVLIFDEVMTGFRVALGGAQAYYGVTPD-------LSTFGKIIGG-GMPVG- 282 Query: 283 VLSLNAELLSY---AAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKI 339 E++ + + A ++ + G+ +++ Sbjct: 283 AFGGKREIMQQISPLGPVYQAGTLSGNPLAMAAGLTTLRLISRPGFHDELTAYTTRMLDG 342 Query: 340 FTSIFDELGLP-YTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHW--LINEL 396 D G+P T G F D E + R + L+ + Sbjct: 343 LQQRADAAGIPFVTTQAGGMF-----GLYFSGADAIVTFEDVMASDVERFKRFFHLMLDG 397 Query: 397 GVVAIPPTEF 406 GV P + F Sbjct: 398 GVYLAP-SAF 406 >2BWN-A nrPDB Length = 401 Score = 47.9 bits (112), Expect = 8e-06, Method: Composition-based stats. Identities = 23/133 (17%), Positives = 49/133 (36%), Gaps = 3/133 (2%) Query: 220 LTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWR 279 + + +I + + DEV+ + +A + ++ + G+ K++ G Sbjct: 197 IKEICDIAEEFGALTYIDEVHAVGMYGPRGAGVAERDGLMHRIDIFNGTLAKAYGVFG-- 254 Query: 280 IGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKI 339 G++ + + + + A I S P A A + LK +K+R K+ Sbjct: 255 -GYIAASARMVDAVRSYAPGFIFSTSLPPAIAAGAQASIAFLKTAEGQKLRDAQQMHAKV 313 Query: 340 FTSIFDELGLPYT 352 LG+P Sbjct: 314 LKMRLKALGMPII 326 >4ZWV-A nrPDB Length = 372 Score = 47.9 bits (112), Expect = 9e-06, Method: Composition-based stats. Identities = 24/131 (18%), Positives = 45/131 (34%), Gaps = 19/131 (14%) Query: 117 NVTVTTGANEGILSCLMGLLNAG--DEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKEL 174 V G+ L L DEV+ F+ I G ++ +V ++P Sbjct: 50 RVVSVHSGTSGLCLALRLLDAPEERDEVLSTPLTFEATNWAILADGRRITWVDVDP---- 105 Query: 175 DQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICV-KHNVV 233 T+D + E+ I+ T+A+I+ G + L + + +H Sbjct: 106 -------ATLTMDLDDLERKISPATRAIIVVHW---TGYPVDLDRLAGILDRAEREHGFR 155 Query: 234 --IISDEVYEH 242 +I D + Sbjct: 156 PAVIEDCAHAW 166 >4GSA-A nrPDB Length = 432 Score = 47.9 bits (112), Expect = 9e-06, Method: Composition-based stats. Identities = 51/347 (14%), Positives = 105/347 (30%), Gaps = 35/347 (10%) Query: 70 QFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGIL 129 I+ + A++ + G P + ++ L + + E V E + Sbjct: 76 PEVIEALKVAMEK------GTSFGAPCALENV--LAEMVNDAVPSIEMVRFVNSGTEACM 127 Query: 130 SCLMGLLNAG--DEVIVFEPFFDQYIPNIEL---CGGKVVYVPINPPKELDQRNTRGEEW 184 + L + D++I FE + + + G + +P +P Sbjct: 128 AVLRLMRAYTGRDKIIKFEGCYHGHADMFLVKAGSGVATLGLPSSPGVPKKTTANTLTTP 187 Query: 185 TIDFEQFEKAITSKTKAV--IINTP--HNPIGKVFTREELTTLGNICVKHNVVIISDEVY 240 D E + + +I P N V L L I ++H+ +++ DEV Sbjct: 188 YNDLEAVKALFAENPGEIAGVILEPIVGNSGFIVPDAGFLEGLREITLEHDALLVFDEVM 247 Query: 241 EHLYFT-DSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKA-- 297 ++P+ + + GK G +G E++ A A Sbjct: 248 TGFRIAYGGVQEKFGVTPD-------LTTLGKIIGG-GLPVG-AYGGKREIMQLVAPAGP 298 Query: 298 -HTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPE- 355 + + A ++ + G +E + Q +I E G + Sbjct: 299 MYQAGTLSGNPLAMTAGIKTLELLRQPGTYEYLDQITKRLSDGLLAIAQETGHAACGGQV 358 Query: 356 GTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIP 402 F F + P + + K R ++ + G+ P Sbjct: 359 SGMF---GFFFTEGPVHNYEDAKKSDLQKFSRFHRGMLEQ-GIYLAP 401 >4P3M-A nrPDB Length = 429 Score = 47.5 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 30/232 (12%), Positives = 63/232 (27%), Gaps = 22/232 (9%) Query: 124 ANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEE 183 ++ + L GD ++ ++ G V + Q E Sbjct: 98 GSQANAAVYQALCAPGDTILGMSLAHGGHLT----HGSHVSF--SGKMYNAVQYGITPET 151 Query: 184 WTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVY-EH 242 +D+ + E+ +II G V + I K + D + Sbjct: 152 GILDYAEIERLAVEHKPTMIIAGFSAYSGIV----DWAKFREIADKVGAYLFVDMAHVAG 207 Query: 243 LYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRIC 302 L + + + + K+ G R G +L+ E + + Sbjct: 208 LVAAGLYPNPVPFAD------VVTTTTHKTLG--GPRGGLILAKANEAIEKKLNSAVFPG 259 Query: 303 FASPSPLQ--EACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYT 352 + A A + + + F +Q+ ++ K F G Sbjct: 260 QQGGPLMHVIAAKAVAFKECAEPE-FAVYQQQVLDNAKAMVKSFLARGYKIV 310 >5TXT-B nrPDB Length = 491 Score = 47.5 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 44/304 (14%), Positives = 92/304 (30%), Gaps = 44/304 (14%) Query: 85 VNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIV 144 N Y P +++++ K Y L + L+ + +V Sbjct: 63 SNDYLALSKHPEVLDAMHKTIDK-YGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALV 121 Query: 145 FEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTI---------DFEQFEKAI 195 F + + L G K+ + I + G + D + E+ + Sbjct: 122 FSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLL 181 Query: 196 TSKTK----AVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTR 251 S K + + ++ G V ++ + ++ K+ + DEV+ + Sbjct: 182 QSYPKSVPKLIAFESVYSMAGSV---ADIEKICDLADKYGALTFLDEVHAVGLYGPHGAG 238 Query: 252 IATLSP----------------------EIGQLTLTVGSAGKSFAATGWRIGWVLSLNAE 289 +A + ++ + G+ GKSF + G G+V + Sbjct: 239 VAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVG---GYVAASRKL 295 Query: 290 LLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGL 349 + + + A I + P A A + + +R F ELG+ Sbjct: 296 IDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRC--HIDLRTSQQKHTMYVKKAFHELGI 353 Query: 350 PYTA 353 P Sbjct: 354 PVIP 357 >3G8M-A nrPDB Length = 417 Score = 47.1 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 48/320 (15%), Positives = 82/320 (25%), Gaps = 37/320 (11%) Query: 44 KAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDI-----PMVNQYSPTRGRPSLI 98 +A K + E I L +Y+ P+ + + + P Y + Sbjct: 17 QAMEQEKVRQEEHIEL-IASENYTSPRVMQAQGSQLTNKFAEGYPGKRYYGGCEYVDIVE 75 Query: 99 NSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIEL 158 I ++ + NV +G+ + + LL GD V+ Sbjct: 76 QLAIDRAKELFGADYA--NVQPHSGS-QANFAVYTALLEPGDTVL----------GMNLA 122 Query: 159 CGGKVV---YVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVF 215 GG + V + ID+ EK +II G V Sbjct: 123 HGGHLTHGSPVNFSGKLYNIVPYGIDATGHIDYADLEKQAKEHKPKMIIGGFSAYSGVV- 181 Query: 216 TREELTTLGNICVKHNVVIISDEVY-EHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFA 274 + + I + D + L + + + T Sbjct: 182 ---DWAKMREIADSIGAYLFVDMAHVAGLVAAGVYPNPVPHAHVVTTTT--------HKT 230 Query: 275 ATGWRIGWVL--SLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQE 332 G R G +L + EL A P A F+ +Q+ Sbjct: 231 LAGPRGGLILAKGGSEELYKKLNSAVFPGGQGGPLMHVIAGKAVALKEAMEPEFKTYQQQ 290 Query: 333 YINKFKIFTSIFDELGLPYT 352 K +F E G Sbjct: 291 VAKNAKAMVEVFLERGYKVV 310 >3WKR-A nrPDB Length = 416 Score = 47.1 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 35/232 (15%), Positives = 69/232 (29%), Gaps = 30/232 (12%) Query: 44 KAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTR----GRPSLIN 99 K N +++ RE INL P+ A K + D V Y R P + + Sbjct: 42 KYKNLTRSLTREFINLNPIQRGGILPKEAKKAVYEYWDGYSVCDYCHGRLDEVTCPPIKD 101 Query: 100 SLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPF-FDQYIPNIEL 158 L + + + T GA EG + + GD V++ + + Y+ Sbjct: 102 FLEDIAKFLNMDCARP-----THGAREGKFIVMHAICKEGDYVVLDKNAHYTSYVAAER- 155 Query: 159 CGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTRE 218 K+ + +E E + + E +++ G+ Sbjct: 156 --AKLNVAEVGYEEEYPTYKINLEGYKEVIDNLEDK-GKNVGLILLTHVD---GEYGNLN 209 Query: 219 ELTTLGNICVKHNVVIISDEVY-------------EHLYFTDSFTRIATLSP 257 + +G I + + + + Y +A +P Sbjct: 210 DAKKVGKIAKEKGIPFLLNCAYTVGRMPVNGKEVKADFIVASGHKSMAASAP 261 >2DKJ-A nrPDB Length = 407 Score = 46.3 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 55/382 (14%), Positives = 114/382 (29%), Gaps = 66/382 (17%) Query: 37 LTNEAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPS 96 +EA + + + RE + L F K+ ++A+ + N+Y+ G P Sbjct: 6 KRDEALFELIALEEKRQREGLELIASE------NFVSKQVREAVGSVLTNKYA--EGYPG 57 Query: 97 LI--------NSLIKLYSPIYNTELKAENVTVTT-GANEGILSCLMGLLNAGDEVIVFEP 147 + + L A V ++ ++ M L+ GD ++ + Sbjct: 58 ARYYGGCEVIDRVESLAIERAKALFGAAWANVQPHSGSQANMAVYMALMEPGDTLMGMDL 117 Query: 148 FFDQYI---PNIELCG--GKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAV 202 ++ + G KVV + P EL ID E+ + V Sbjct: 118 AAGGHLTHGSRVNFSGKLYKVVSYGVRPDTEL-----------IDLEEVRRLALEHRPKV 166 Query: 203 IINTPHNPIGKVFTRE--ELTTLGNICVKHNVVIISDEVY-EHLYFTDSFTRIATLSPEI 259 I+ G + I + ++ D + L + Sbjct: 167 IV------AGASAYPRFWDFKAFREIADEVGAYLVVDMAHFAGLVAAGLHPNPLPYA--- 217 Query: 260 GQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEAC-ANSIN 318 + + K+ G R G +LS + EL K P A A + Sbjct: 218 ---HVVTSTTHKTLR--GPRGGLILSNDPELGKRIDKLIFPGIQGGPLEHVIAGKAVAFF 272 Query: 319 DALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEE 378 +AL+ F++ + + K G +++ + + Sbjct: 273 EALQPE-FKEYSRLVVENAKRLAEELARRGYRIV--------------TGGTDNHLFLVD 317 Query: 379 ILNKGKDFRISHWLINELGVVA 400 + KG + + ++ +G+ Sbjct: 318 LRPKGLTGKEAEERLDAVGITV 339 >4J5U-A nrPDB Length = 420 Score = 46.0 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 54/328 (16%), Positives = 105/328 (32%), Gaps = 42/328 (12%) Query: 38 TNEAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTR---GR 94 T++ + + K + +I L ++ P ++ L Y R G Sbjct: 11 TDKEINEIIKHEKLRQSSVIEL-IASENFVSP-AVLEAQGALLTNKYAEGYPSKRFYNGC 68 Query: 95 PSLINS---LIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQ 151 + + I+ ++N + NV +G+ + + + LL GD V+ Sbjct: 69 EEVDKAENLAIERVKKLFNCKYA--NVQPHSGS-QANQAVYLALLQPGDTVL-------- 117 Query: 152 YIPNIELCGGKVVY--VPINPPKELDQRNTR--GEEWTIDFEQFEKAITSKTKAVIINTP 207 GG + + P K + + E + ID+++ E+ ++I Sbjct: 118 --GMSLDSGGHLTHGAAPNMSGKWFNAVSYSVNKETYLIDYDEIERLADLHKPKLLIAGF 175 Query: 208 HNPIGKVFTRE-ELTTLGNICVKHNVVIISDEVY-EHLYFTDSFTRIATLSPEIGQLTLT 265 + R + I K ++D + L T + + T Sbjct: 176 S-----AYPRNIDFAKFREIVDKVGAYFMADIAHIAGLVATGEHQSPIPYAHAVTSTTH- 229 Query: 266 VGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASP-SPLQEACANSINDALKIG 324 K+ G R G +LS + E+ A P + A A + + L+ Sbjct: 230 -----KTLR--GPRGGLILSNDEEIGHKINSALFPGLQGGPLMHIIAAKAVAFLENLQPE 282 Query: 325 YFEKMRQEYINKFKIFTSIFDELGLPYT 352 Y + Q+ I+ K S E G Sbjct: 283 Y-KSYIQQVISNAKALASSLQERGYDIL 309 >1IBJ-A nrPDB Length = 464 Score = 45.6 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 36/227 (15%), Positives = 74/227 (32%), Gaps = 40/227 (17%) Query: 88 YSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEP 147 Y TR ++L L + + + T+G LS + L+ G+E++ + Sbjct: 125 YDYTRSGNPTRDALESLLAKLDKAD---RAFCFTSGM--AALSAVTHLIKNGEEIVAGDD 179 Query: 148 FFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTP 207 + + VP + T+ ++ AI +TK V + +P Sbjct: 180 VYGGSDRLLSQ------VVPRSGVVVKRVNTTK-------LDEVAAAIGPQTKLVWLESP 226 Query: 208 HNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVG 267 NP ++ + + +++ D + +R L + + + Sbjct: 227 TNP---RQQISDIRKISEMAHAQGALVLVDNS----IMSPVLSRPLELGAD-----IVMH 274 Query: 268 SAGKSFA-----ATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPL 309 SA K A G VL++ E L+ + +P Sbjct: 275 SATKFIAGHSDVMAG-----VLAVKGEKLAKEVYFLQNSEGSGLAPF 316 >3GBX-A nrPDB Length = 420 Score = 45.6 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 47/320 (14%), Positives = 83/320 (25%), Gaps = 37/320 (11%) Query: 44 KAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDI-----PMVNQYSPTRGRPSLI 98 +A K + E I L +Y+ P+ + + + P Y + Sbjct: 20 QAMEQEKVRQEEHIEL-IASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEYVDVVE 78 Query: 99 NSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIEL 158 I ++ + NV +G+ + + LL GD V+ Sbjct: 79 QLAIDRAKELFGADYA--NVQPHSGS-QANFAVYTALLQPGDTVL----------GMNLA 125 Query: 159 CGGKVV---YVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVF 215 GG + V + E ID+++ K +II G V Sbjct: 126 QGGHLTHGSPVNFSGKLYNIVPYGIDESGKIDYDEMAKLAKEHKPKMIIGGFSAYSGVV- 184 Query: 216 TREELTTLGNICVKHNVVIISDEVY-EHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFA 274 + + I + D + L + + + T Sbjct: 185 ---DWAKMREIADSIGAYLFVDMAHVAGLIAAGVYPNPVPHAHVVTTTT--------HKT 233 Query: 275 ATGWRIGWVL--SLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQE 332 G R G +L + EL A P A F+ +Q+ Sbjct: 234 LAGPRGGLILAKGGDEELYKKLNSAVFPSAQGGPLMHVIAGKAVALKEAMEPEFKVYQQQ 293 Query: 333 YINKFKIFTSIFDELGLPYT 352 K +F G Sbjct: 294 VAKNAKAMVEVFLNRGYKVV 313 >3NDN-A nrPDB Length = 414 Score = 45.6 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 37/240 (15%), Positives = 71/240 (29%), Gaps = 34/240 (14%) Query: 72 AIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSC 131 A K LD + ++Y + ++ A T + + Sbjct: 62 AEKSFAGELDHYVYSRYGNPT---------VSVFEERLRLIEGAPAAFATASGMAAVFTS 112 Query: 132 LMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQF 191 L LL AGD ++ G V + + D Q+ Sbjct: 113 LGALLGAGDRLV-----------AARSLFGSCFVVCSEILPRWGVQTVFVDG--DDLSQW 159 Query: 192 EKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTR 251 E+A++ T+AV TP NP + + ++ + + ++ D V+ F Sbjct: 160 ERALSVPTQAVFFETPSNP---MQSLVDIAAVTELAHAAGAKVVLDNVFATPLLQQGFP- 215 Query: 252 IATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQE 311 + + V S K G +G + + E + + R + S Sbjct: 216 --------LGVDVVVYSGTKHIDGQGRVLGGAILGDREYIDGPVQKLMRHTGPAMSAFNA 267 >2DR1-A nrPDB Length = 386 Score = 45.2 bits (105), Expect = 6e-05, Method: Composition-based stats. Identities = 45/257 (17%), Positives = 84/257 (32%), Gaps = 30/257 (11%) Query: 111 TELKAENVTVTTGANEGILSC-LMGLLNAGDEVIV-FEPFFDQ-YIPNIELCGGKVVYVP 167 E++ V + + GI+ + ++ G +V+V F + Y +E G K V + Sbjct: 66 LEVEKGEVLLVPSSGTGIMEASIRNGVSKGGKVLVTIIGAFGKRYKEVVESNGRKAVVLE 125 Query: 168 INPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGK-VFTREELTTLGNI 226 P K + E + A+ + +N V L L + Sbjct: 126 YEPGK------------AVKPEDLDDALRKNPDVEAVTITYNETSTGVLNP--LPELAKV 171 Query: 227 CVKHNVVIISDEVY----EHLYFTDSFTRIATLSPEIGQLT---LTVGSAGKSFAATGWR 279 +H+ ++ D V + F + S + L +G+ + F + Sbjct: 172 AKEHDKLVFVDAVSAMGGADIKFDKWGLDVVFSSSQKAFGVPPGLAIGAFSERFLEIAEK 231 Query: 280 I---GWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINK 336 + GW + L K P P ++ K+G EK + Y + Sbjct: 232 MPERGW--YFDIPLYVKYLKEKESTPSTPPMPQVFGINVALRIIEKMGGKEKWLEMYEKR 289 Query: 337 FKIFTSIFDELGLPYTA 353 K+ E+GL A Sbjct: 290 AKMVREGVREIGLDILA 306 >3ISL-A nrPDB Length = 416 Score = 44.8 bits (104), Expect = 7e-05, Method: Composition-based stats. Identities = 43/302 (14%), Positives = 87/302 (28%), Gaps = 43/302 (14%) Query: 67 SPPQFAIKEAQKALDIPMVNQYSPTR-GRP-SLINSLIKLYSPIYNTELKAENVTVTTGA 124 P + + P+V Q+ P G + L +L+ + + Sbjct: 17 PGPVEVDPRVLRVMSTPVVGQFDPAFTGIMNETMEMLRELFQTKNRWAYPIDGT-----S 71 Query: 125 NEGILSCLMGLLNAGDEVIVFEPFFDQYI--PNIELCGGKVVYVPINPPKELDQRNTRGE 182 GI + L ++ D+V++ Y+ E G V + D + Sbjct: 72 RAGIEAVLASVIEPEDDVLIPIYGRFGYLLTEIAERYGANVHMLECEWGTVFDPEDI--- 128 Query: 183 EWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEH 242 + K K V + G++ L +G C + + I D V Sbjct: 129 --------IREIKKVKPKIVAMVHGETSTGRIHP---LKAIGEACRTEDALFIVDAV--- 174 Query: 243 LYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAAT-GW-------RIGWVLSLNAELLSYA 294 ++ + +G K + G R+ V++ ++ Sbjct: 175 ATIGGCEVKVDEWKIDAA-----IGGTQKCLSVPSGMAPITYNERVADVIAARKKVERGI 229 Query: 295 AKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAP 354 A R + P+ N + + Y+ + R + + E G+ Sbjct: 230 ATQADRAALSGNRPITS---NYFDLSQLEDYWSERRLNHHTEATTMLYALRE-GVRLVLE 285 Query: 355 EG 356 EG Sbjct: 286 EG 287 >3HMU-A nrPDB Length = 472 Score = 44.4 bits (103), Expect = 9e-05, Method: Composition-based stats. Identities = 56/342 (16%), Positives = 113/342 (33%), Gaps = 40/342 (11%) Query: 26 FTSNTAKDVWSLTNEAAAKAANNSKNQGRELINLGQG----FFSYSPPQFAIKEAQKALD 81 F++N A A+ + ++G E+++ G Y + A A++ + Sbjct: 27 FSANNALGEEGTRVITRARGVWLNDSEGEEILDAMAGLWCVNIGYGRDELAEVAARQMRE 86 Query: 82 IPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLL----- 136 +P N + T P++ +L + + + +L +V G +E + + + Sbjct: 87 LPYYNTFFKTTHVPAI--ALAQKLAELAPGDL--NHVFFAGGGSEANDTNIRMVRTYWQN 142 Query: 137 --NAGDEVIVFE-PFFDQYIPNIELCGG----KVVYVPINPPKELDQRNTRGEEWTIDFE 189 VI+ + GG I ++Q N E +D E Sbjct: 143 KGQPEKTVIISRKNAYHGSTVASSALGGMAGMHAQSGLIPDVHHINQPNWWAEGGDMDPE 202 Query: 190 Q--------FEKAI---TSKTKAVIINTPHNPIGKVF--TREELTTLGNICVKHNVVIIS 236 + E+AI A I P G V + IC K+++++I+ Sbjct: 203 EFGLARARELEEAILELGENRVAAFIAEPVQGAGGVIVAPDSYWPEIQRICDKYDILLIA 262 Query: 237 DEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLN-AELLSYAA 295 DEV T ++ T+ +T+ +A G G ++ A ++ Sbjct: 263 DEVICGFGRTGNWFGTQTMGIRPHIMTI-AKGLSSGYAPIG---GSIVCDEVAHVIGKDE 318 Query: 296 KAHTRICFASPSPLQEACAN--SINDALKIGYFEKMRQEYIN 335 H P A N + + + + + Y+ Sbjct: 319 FNHGYTYSGHPVAAAVALENLRILEEENILDHVRNVAAPYLK 360 >3N0L-A nrPDB Length = 417 Score = 44.4 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 35/328 (10%), Positives = 95/328 (28%), Gaps = 43/328 (13%) Query: 83 PMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEV 142 P Y + I+ ++N + NV +G+ + L+N GD++ Sbjct: 58 PGKRYYGGCEFVDEIETLAIERCKKLFNCKFA--NVQPNSGS-QANQGVYAALINPGDKI 114 Query: 143 IVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAV 202 + + ++ G K V + + ID+E+ + + + Sbjct: 115 LGMDLSHGGHLT----HGAK---VSSSGKMYESCFYGVELDGRIDYEKVREIAKKEKPKL 167 Query: 203 IINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVY-EHLYFTDSFTRIATLSPEIGQ 261 I+ + I + + +D + L + Sbjct: 168 IVCGAS----AYARVIDFAKFREIADEIGAYLFADIAHIAGLVVAGEHPSPFPYA----- 218 Query: 262 LTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDAL 321 + + K+ G R G ++ N E L+ + + A ++ Sbjct: 219 -HVVSSTTHKTLR--GPRGG-IIMTNDEELAKKINSAIFPGIQGGPLMHVIAAKAVGFKF 274 Query: 322 KIG-YFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEIL 380 + ++ ++ ++ ++ + +GT +++ L Sbjct: 275 NLSDEWKVYAKQVRTNAQVLANVLMDRKFKLV-SDGT-------------DNHLVLMSFL 320 Query: 381 NKGKDFRISHWLINELGVVA----IPPT 404 ++ + + + G+ A +P Sbjct: 321 DREFSGKDADLALGNAGITANKNTVPGE 348 >2CB1-A nrPDB Length = 412 Score = 44.0 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 48/263 (18%), Positives = 84/263 (31%), Gaps = 38/263 (14%) Query: 60 GQGFFSYSPPQFAIKEAQKALDI-PMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENV 118 G Y+ + K ++ + Y R + +L + + E V Sbjct: 19 AVGLPIYAVAAYGFKTLEEGQERFATGEGYVYARQKDPTAKALEERLKALEGA---LEAV 75 Query: 119 TVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYI----PNIELCGGKVVYVPINPPKEL 174 + +G + L+ LL GDEV+ + F Q I + L G V YV Sbjct: 76 VLASG-QAATFAALLALLRPGDEVVAAKGLFGQTIGLFGQVLSLMGVTVRYVD------- 127 Query: 175 DQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVI 234 + E +A+++KT+AV + T NP V +L L + + V + Sbjct: 128 -----------PEPEAVREALSAKTRAVFVETVANPALLV---PDLEALATLAEEAGVAL 173 Query: 235 ISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYA 294 + D F + L+ + V S K + G +G + L Sbjct: 174 VVDN-----TFGAAGALCRPLAWGAH---VVVESLTKWASGHGSVLGGAVLSRETELWRN 225 Query: 295 AKAHTRICFASPSPLQEACANSI 317 + P + A Sbjct: 226 YPQFLQPDLKGQIPWEALRARCF 248 >1WYV-B nrPDB Length = 474 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 29/177 (16%), Positives = 59/177 (33%), Gaps = 21/177 (11%) Query: 69 PQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTE-LKAENVTVTTGANEG 127 P+ + A+ D+ +G L+ L + + + + E G G Sbjct: 80 PKLHEEAARLFADLHPYQDPRTAQGALRLMWELGEYLKALTGMDAITLEPAAGAHGELTG 139 Query: 128 ILSCLMGLLNAGDE-----VIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGE 182 IL + G+ V+V + + G +V +P P Sbjct: 140 ILIIRAYHEDRGEGRTRRVVLVPDSAHGSNPATASMAGYQVREIPSGP------------ 187 Query: 183 EWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEV 239 E +D E ++ + A+++ P+ +F R L + +C + V + D Sbjct: 188 EGEVDLEALKRELGPHVAALMLTNPN--TLGLFERRILE-ISRLCKEAGVQLYYDGA 241 >5IJG-A nrPDB Length = 427 Score = 43.6 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 25/174 (14%), Positives = 52/174 (29%), Gaps = 15/174 (8%) Query: 102 IKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGG 161 ++ AE+ + + I + L + GD ++ +P + + Sbjct: 85 SEIVEDRLAVYEGAESAALFSSGMSAIATTLFAFVRPGDVILHSQPLYGGTETLL----A 140 Query: 162 KVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELT 221 K + N E E TI+ E + ++I TP NP + + Sbjct: 141 KTFF---NFGVEAVAFADGVHEATIEKAAEEALAKGRVSVILIETPANPTNSIVDVAAVR 197 Query: 222 TLGN-ICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFA 274 + I + + ++ F + + L+V S K Sbjct: 198 RVAEKIEARQGSRPVI--ACDNTLLGPVFQKPLDHGAD-----LSVYSLTKYVG 244 >4OBV-D nrPDB Length = 490 Score = 43.6 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 26/168 (15%), Positives = 60/168 (35%), Gaps = 22/168 (13%) Query: 99 NSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVI--VFEPFFDQYI--- 153 ++K + V V+ G+ ++ + L A D + + YI Sbjct: 135 QEVLKWLAKQVGFTENPGGVFVSGGS----MANITALTAARDNKLTDINLHLGTAYISDQ 190 Query: 154 -PNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTK-----AVIINTP 207 + G +++ + + + + + +D + E+AI + K V+I T Sbjct: 191 THSSVAKGLRIIGITDSRIRRIP----TNSHFQMDTTKLEEAIETDKKSGYIPFVVIGTA 246 Query: 208 HNPIGKVFTREELTTLGNICVKHNVVIISDEVYEH-LYFTDSFTRIAT 254 + + LT + +C KH++ D Y + + + + T Sbjct: 247 G--TTNTGSIDPLTEISALCKKHDMWFHIDGAYGASVLLSPKYKSLLT 292 >4U1T-A nrPDB Length = 389 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 37/250 (14%), Positives = 71/250 (28%), Gaps = 45/250 (18%) Query: 60 GQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVT 119 G PP ++ Y RG L + + E Sbjct: 18 SAGTGDVVPPIHVSTTYERRAQDEPRYFYG--RGENPTREELEECLA---GLERAPFATV 72 Query: 120 VTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELC---GGKVVYVPINPPKELDQ 176 ++G + + L+ L+ G V+ + + +L G +V Y + Sbjct: 73 FSSG--QAAAATLLSLVRPGQCVVSTDDVYAGTDGLFDLAARQGVRVRYADLTT------ 124 Query: 177 RNTRGEEWTIDFEQFEKAIT-SKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVII 235 E A+ V I TP NP+ V E++ + ++ Sbjct: 125 -----------PEGIAAALAEPDLALVWIETPTNPLLTVVDVAEVSR---RAHERGARVV 170 Query: 236 SDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATG---WRIGWVLSLNAELLS 292 D ++F P +++ S K + G G ++ +A+L + Sbjct: 171 VD---------NTFASPVLQQPLALGADVSLYSTTK--SIAGHADVLGGALVYRDADLHA 219 Query: 293 YAAKAHTRIC 302 T Sbjct: 220 AVRAYRTTAG 229 >3NNK-A nrPDB Length = 411 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 36/174 (20%), Positives = 70/174 (40%), Gaps = 19/174 (10%) Query: 67 SPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTG-AN 125 P A +A+ ++ QY P +N ++ LY ++ T + + G + Sbjct: 19 PGPINADPRVLRAMSSQLIGQYDPAMTHY--MNEVMALYRGVFRT--ENRWTMLVDGTSR 74 Query: 126 EGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNT-RGEEW 184 GI + L+ + GD+V+V P F ++ G + + E+ GE + Sbjct: 75 AGIEAILVSAIRPGDKVLV--PVFGRF-------GHLLCEIARRCRAEVHTIEVPWGEVF 125 Query: 185 TIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDE 238 T D Q E A+ + + ++ T + L LG IC +++ + +D Sbjct: 126 TPD--QVEDAVK-RIRPRLLLTVQGDTSTTM-LQPLAELGEICRRYDALFYTDA 175 >2E54-A nrPDB Length = 385 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 46/257 (17%), Positives = 85/257 (33%), Gaps = 38/257 (14%) Query: 187 DFEQFEKAITSKTKAVIINTPHNPIGKV-FTREELTTLGNICVKHNVVIISDEVYEHLYF 245 + E + ++ AV + G V T+E L +C +++ +++ DEV + Sbjct: 160 NVEDLRRKMSEDVCAVFLEPIQGESGIVPATKEFLEEARKLCDEYDALLVFDEVQCGMGR 219 Query: 246 TDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFAS 305 T + + + V + K G IG V+ E + F Sbjct: 220 TGKL-----FAYQKYGVVPDVLTTAKGLGG-GVPIGAVIVN--ERANVLEPGDHGTTFGG 271 Query: 306 PSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFS 365 A I + K G+ E E K E+ Y V+ D Sbjct: 272 NPLACRAGVTVIKELTKEGFLE----EVEEKGNYLMKKLQEMKEEYD-------VVADVR 320 Query: 366 KVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRF--AV 423 + + + EE+ N+ + E ++ +P A N +RF + Sbjct: 321 GMGLMIGIQFREEVSNREVATKCF-----ENKLLVVP-----------AGNNTIRFLPPL 364 Query: 424 CKDDAYLENAVERLKLL 440 + ++ AVE LK + Sbjct: 365 TVEYGEIDLAVETLKKV 381 >3RUY-A nrPDB Length = 392 Score = 42.9 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 29/173 (16%), Positives = 54/173 (31%), Gaps = 8/173 (4%) Query: 187 DFEQFEKAITSKTKAVIINTPHNPIGKVFTRE-ELTTLGNICVKHNVVIISDEVYEHLYF 245 D E + AIT T A I+ G L +C K NV+ ++DE+ L Sbjct: 171 DLEALKAAITPNTAAFILEPIQGEAGINIPPAGFLKEALEVCKKENVLFVADEIQTGLGR 230 Query: 246 TDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFAS 305 T + + +T + GK+ + I + N ++L F Sbjct: 231 TGK-----VFACDWDNVTPDMYILGKALGGGVFPISCAAA-NRDILGVFEPGSHGSTFGG 284 Query: 306 PSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTY 358 ++ + L+ + + K D + +G + Sbjct: 285 NPLACAVSIAAL-EVLEEEKLTERSLQLGEKLVGQLKEIDNPMITEVRGKGLF 336 >5LL2-A nrPDB Length = 480 Score = 42.9 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 63/367 (17%), Positives = 115/367 (31%), Gaps = 55/367 (14%) Query: 12 LMSTSRPKVVANKYFTSNTAKDVWSLTNEAAAKAANNSKNQGRELINLGQGFFSYSPPQF 71 L S+ NKY+ + + ++L + A A G + I+L + + Sbjct: 34 LDKASKLIDEENKYYARSARINYYNLVID-HAHGATLVDVDGNKYIDLLASASAINV-GH 91 Query: 72 AIKEAQKAL--DIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGIL 129 ++ KA+ + Y+P + + EL + + G + ++ Sbjct: 92 THEKVVKAIADQAQKLIHYTPA------------YFHHVPGMELSEKLAKIAPGNSPKMV 139 Query: 130 SCLMGLLNAGDEVIVFEPFFDQYIPNIELCG---------------------------GK 162 S +A D +I F + + G Sbjct: 140 SFGNSGSDANDAIIKFARAYTGRQYIVSYMGSYHGSTYGSQTLSGSSLNMTRKIGPMLPS 199 Query: 163 VVYVPINPPKELDQRNTRGEEWTIDFEQFEK-----AITSKTKAVIINTPHNPIGKVFTR 217 VV+VP T + F +F+K +T V+I G + Sbjct: 200 VVHVPYPDSYRTYPGETEHDVSLRYFNEFKKPFESFLPADETACVLIEPIQGDGGIIKAP 259 Query: 218 EE-LTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAAT 276 EE + + C +H ++ DEV + L T I + S GKS A + Sbjct: 260 EEYMQLVYKFCHEHGILFAIDEVNQGLGRTGKMWAIQQFKDIEPD----LMSVGKSLA-S 314 Query: 277 GWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINK 336 G + V+ + S A AH +P A +++ G EK + Sbjct: 315 GMPLSAVIGKKEVMQSLDAPAHLFTTAGNP-VCSAASLATLDVIEYEGLVEKSATDGAYA 373 Query: 337 FKIFTSI 343 + F + Sbjct: 374 KQRFLEM 380 >4J8L-A nrPDB Length = 361 Score = 42.9 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 33/228 (14%), Positives = 68/228 (29%), Gaps = 34/228 (14%) Query: 124 ANEGILSCLMGLLNAGDEVIVFE-PFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGE 182 I + L LL G ++V + P + IE G ++ V N L Q Sbjct: 75 GTGAIRAGLAALLKPGQRLLVHDAPVYPTTRVIIEQMGLTLITVDFNDLSALKQ------ 128 Query: 183 EWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEH 242 +D +Q + A+ T+ P L + V ++D+ Y Sbjct: 129 --VVDEQQPDAALVQHTR-------QQP----QDSYVLADVLATLRAAGVPALTDDNYAV 175 Query: 243 LYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRIC 302 + ++A + E G T K F G +G V+ +A++++ + Sbjct: 176 M-------KVARIGCECGANVSTFSCF-KLFGPEG--VGAVVG-DADVINRI---RATLY 221 Query: 303 FASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLP 350 + + ++ + + + Sbjct: 222 SGGSQIQGAQALEVLRGLVFAPVMHAVQAGVSERLLALLNGGAVPEVK 269 >2EH6-A nrPDB Length = 375 Score = 42.1 bits (97), Expect = 6e-04, Method: Composition-based stats. Identities = 40/216 (18%), Positives = 65/216 (30%), Gaps = 21/216 (9%) Query: 187 DFEQFEKAITSKTKAVIINTPHNPIGKV-FTREELTTLGNICVKHNVVIISDEVYEHLYF 245 D + K + +T +II G + + L+ L IC + +V++I DEV + Sbjct: 161 DIDSVYKLLDEETAGIIIEVIQGEGGVNEASEDFLSKLQEICKEKDVLLIIDEVQTGIGR 220 Query: 246 TDSFTRI--ATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICF 303 T F L P+ V + K G IG +L+ E+ F Sbjct: 221 TGEFYAYQHFNLKPD-------VIALAKGLGG-GVPIGAILA-REEVAQSFTPGSHGSTF 271 Query: 304 ASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYF---V 360 A +++ EK+ F ELG G + Sbjct: 272 GGNPLACRAGTVVVDE------VEKLLPHVREVGNYFKEKLKELGKGKVKGRGLMLGLEL 325 Query: 361 LVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINEL 396 + + GK R LI + Sbjct: 326 ERECKDYVLKALEKGLLINCTAGKVLRFLPPLIIQK 361 >5Z0Y-A nrPDB Length = 470 Score = 41.7 bits (96), Expect = 7e-04, Method: Composition-based stats. Identities = 39/308 (12%), Positives = 78/308 (25%), Gaps = 53/308 (17%) Query: 78 KALDIPMVNQYSPTRGRPSLI-----------------NSLIKLYSPIYNTELKAENVTV 120 AL PM N+Y + G P +L + + Sbjct: 55 DALGTPMCNKY--SEGYPGARYYGGNEHIDRMEILCQQRALKAFHLDGSRWGVN----VQ 108 Query: 121 TTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYV-PINPPKELDQRNT 179 T + L ++ D ++ + + ++ E Sbjct: 109 TLSGSPANLQVYQAIMKPHDRLMGLD--LPHGGHLSHGYQTDTRKISAVSTYFETMPYRV 166 Query: 180 RGEEWTIDFEQFEK-AITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDE 238 E ID++ EK A+ + K ++ + + I K ++ D Sbjct: 167 DLETGIIDYDMLEKTAVLYRPKVLVAG-----TSAYCRLIDYKRMREIADKVGAYLVVDM 221 Query: 239 VY-EHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATG-----WRIGWVLSLNAELLS 292 + L + + + KS +R G Sbjct: 222 AHISGLIAAGVIPSPFEYAD------IVTTTTHKSLRGPRGAMIFFRKGVRSVNPKTGKE 275 Query: 293 YAAKAHTRICFASPSPLQ--------EACANSINDALKIGYFEKMRQEYINKFKIFTSIF 344 I F+ Q A A ++ A F++ +++ + K + F Sbjct: 276 IYYDLENPINFSVFPGHQGGPHNHTIAALATALKQAATPE-FKQYQEQVLKNAKALENEF 334 Query: 345 DELGLPYT 352 LG Sbjct: 335 KRLGYKLV 342 >4OTL-A nrPDB Length = 423 Score = 41.3 bits (95), Expect = 8e-04, Method: Composition-based stats. Identities = 46/318 (14%), Positives = 88/318 (27%), Gaps = 36/318 (11%) Query: 44 KAANNSKNQGRELINLGQGF----FSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLIN 99 A + + I L + Q + + A P Y + Sbjct: 26 AAIEQENRRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQ 85 Query: 100 SLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELC 159 I ++ +A NV +G+ + +L GD ++ Sbjct: 86 LAIDRVKQLFGA--EAANVQPNSGS-QANQGVFFAMLKPGDTIM----------GMSLAH 132 Query: 160 GGKVV---YVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFT 216 GG + V ++ E ID++ EK +I+ F Sbjct: 133 GGHLTHGSPVNMSGKWFNVVSYGLNENEDIDYDAAEKLANEHKPKLIVAGAS-----AFA 187 Query: 217 RE-ELTTLGNICVKHNVVIISDEV-YEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFA 274 + + L I ++ D Y L + P +T T + Sbjct: 188 LKIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPV---PHADFVTTTTHK-----S 239 Query: 275 ATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYI 334 G R G +L + I + A A + +AL F++ +Q+ + Sbjct: 240 LRGPRGGVILMKAEYEKPINSAIFPGIQGGPLMHVIAAKAVAFKEALSPE-FKEYQQKVV 298 Query: 335 NKFKIFTSIFDELGLPYT 352 ++ + GL Sbjct: 299 ENARVLAETLVKRGLRIV 316 >4W8I-A nrPDB Length = 551 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 21/132 (15%), Positives = 41/132 (31%), Gaps = 21/132 (15%) Query: 119 TVTTGANEGILSCLMGLLNAGD-------EVIVFEPFFDQYIPNIELCGGKVVYVPINPP 171 +T G I+ + + E++V E + EL G ++ VP++ Sbjct: 161 LLTHGGTTSIIEAMAAYVIRARAKGIDYPEIVVPETAHAAFKKAAELTGAILITVPVD-- 218 Query: 172 KELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHN 231 + ++ IT T ++ P + ++ LG + K N Sbjct: 219 ---------KKTGAVNPNVMSSYITRNTAVMV---GSAPSFMNGIHDPISELGQLAKKKN 266 Query: 232 VVIISDEVYEHL 243 V D Sbjct: 267 VPFHVDACLGGF 278 >2EO5-A nrPDB Length = 419 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 47/326 (14%), Positives = 95/326 (29%), Gaps = 43/326 (13%) Query: 53 GRELINLGQGFFSYS-PPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNT 111 G + NL G+ S+ + I++ QK + Y+ + L L+ + Sbjct: 50 GIGVNNL--GWPSHPEVIKIGIEQMQKLAHAAANDFYNIPQ--LELAKKLVTYSPGNFQK 105 Query: 112 ELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFE------PFFDQYIPNIELC------ 159 + V + E I + + + N G + I+ F Sbjct: 106 K-----VFFSNSGTEAIEASIKVVKNTGRKYIIAFLGGFHGRTFGSISLTASKAVQRSIV 160 Query: 160 -----GGKVVYVP--------INPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINT 206 G V P IN + + R E+ D+ + + Sbjct: 161 GPFMPGVIHVPYPNPYRNPWHINGYENPSELVNRVIEFIEDYIFVNLVPPEEVAGIFFEP 220 Query: 207 PHNPIGKVFTREEL-TTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLT 265 G V + L + K+ ++++ DEV L T I E Sbjct: 221 IQGEGGYVIPPKNFFAELQKLAKKYGILLVDDEVQMGLGRTGKLFAI-----ENFNTVPD 275 Query: 266 VGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGY 325 V + K+ IG + ++T A + + + D L + Sbjct: 276 VITLAKALGGGIMPIGATIFRKDLDFKPGMHSNTFGGNALACAIGSKVIDIVKDLLP--H 333 Query: 326 FEKMRQEYINKFKIFTSIFDELGLPY 351 ++ + + + + +GL + Sbjct: 334 VNEIGKIFAEELQGLADDVRGIGLAW 359 >3A9Z-A nrPDB Length = 432 Score = 40.6 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 37/308 (12%), Positives = 76/308 (24%), Gaps = 40/308 (12%) Query: 65 SYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGA 124 Q + ++A P + + + + + + L I K +++ T+G Sbjct: 31 EPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTARASLAKMIGG---KPQDIIFTSGG 87 Query: 125 NEGILSCLMGLLN--------AGDEVIVFEP---FFDQYIPNIELCGGKVVYVPINPPKE 173 E + + G V P +I + + + Sbjct: 88 TESNNLVIHSTVRCFHEQQTLQGRTVDQISPEEGTRPHFITCTVEHDSIRLPLEHLVEDQ 147 Query: 174 LDQRN---TRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREE----LTTLGNI 226 + + ++ E A+ T V I +N G + E + L I Sbjct: 148 VAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIMLANNETGVIMPISEISRRIKALNQI 207 Query: 227 CVKHN---VVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWV 283 V++ +D R+ + LT+ G RIG + Sbjct: 208 RAASGLPRVLVHTDAAQAL-----GKRRVDVEDLGVDFLTIVGHKF------YGPRIGAL 256 Query: 284 ----LSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGY-FEKMRQEYINKFK 338 + L F + A A + E + Sbjct: 257 YVRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVSENCETYEAHMRDIRD 316 Query: 339 IFTSIFDE 346 + Sbjct: 317 YLEERLEA 324 >3GZD-A nrPDB Length = 440 Score = 40.6 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 39/309 (12%), Positives = 80/309 (25%), Gaps = 42/309 (13%) Query: 67 SPPQFAIKEAQKALDIPMVNQ---YSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTG 123 I+ KA+ N YS R +IN+ + + + K +++ T+G Sbjct: 36 PLEPEVIQAMTKAMWEAWGNPSSPYSAGRKAKDIINAARESLAKMIGG--KPQDIIFTSG 93 Query: 124 ANEGILSCLMGLLNAG--------------DEVIVFEPFFDQYIPNIELCGGKVVYVPIN 169 E + ++ V +P F + + ++ Sbjct: 94 GTESNNLVIHSVVKHFHANQTSKGHTGGHHSPVKGAKPHFITSSVEHDSIRLPLEHLVEE 153 Query: 170 PPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREEL-TTLGNICV 228 + + + A+ T+ V I +N G V E+ + + Sbjct: 154 QVAAVTFVPVSKVSGQTEVDDILAAVRPTTRLVTIMLANNETGIVMPVPEISQRIKALNQ 213 Query: 229 KH------NVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIG- 281 + +++ +D R+ + LT+ G RIG Sbjct: 214 ERVAAGLPPILVHTDAAQAL-----GKQRVDVEDLGVDFLTIVGHKF------YGPRIGA 262 Query: 282 -WV--LSLNAELLSYAAKAHTRICFASPSPLQEACANSINDA-LKIGYFEKMRQEYINKF 337 ++ L L F + A A L E + Sbjct: 263 LYIRGLGEFTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAAELVTQNCEAYEAHMRDVR 322 Query: 338 KIFTSIFDE 346 + Sbjct: 323 DYLEERLEA 331 >1SVV-A nrPDB Length = 359 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 52/328 (15%), Positives = 84/328 (25%), Gaps = 45/328 (13%) Query: 117 NVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQY--IPNIELCGGKVVYVPINPPKEL 174 +V +G + L L + VI + IE G KVV P Sbjct: 68 DVHFISGGTQTNLIACSLALRPWEAVIATQLGHISTHETGAIEATGHKVVTAPC------ 121 Query: 175 DQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVI 234 R + + K V I+ +G +T++EL + C +H + + Sbjct: 122 PDGKLRVADIESALHENRSEHMVIPKLVYISN-TTEVGTQYTKQELEDISASCKEHGLYL 180 Query: 235 ISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYA 294 D S TL+ + A K+ G + + LN L A Sbjct: 181 FLDGA-RLASALSSPVNDLTLADIARLTDMFYIGATKAGGMFGEAL---IILNDALKPNA 236 Query: 295 AKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAP 354 + +K F ++ I + + G+ Sbjct: 237 RHLIKQRGALMAKG--WLLGIQFEVLMKDNLFFELGAHSNKMAAILKAGLEACGIR---- 290 Query: 355 EGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKA 414 S P LN D Y E K Sbjct: 291 ----LAWPSASNQLFPILENTMIAELNNDFDM--------------------YTVEPLKD 326 Query: 415 AENLLRFA--VCKDDAYLENAVERLKLL 440 ++R ++ VE LK L Sbjct: 327 GTCIMRLCTSWATEEKECHRFVEVLKRL 354 >3WY7-A nrPDB Length = 404 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 32/202 (15%), Positives = 59/202 (29%), Gaps = 35/202 (17%) Query: 93 GRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQY 152 G L + + AE+ V + L L+ L G ++ Sbjct: 99 GNTELHEAFEHQLASFLG----AESALVFSSGYTANLGALVALSGPGSLIVSDALSHASL 154 Query: 153 IPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIG 212 + L +VV P +D E +AV++ Sbjct: 155 VDACRLSRARVVVSPHRDVDAVDAALAARTE---------------ERAVVV------TE 193 Query: 213 KVFTREE----LTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLS--PEIGQLTLTV 266 VF+ + L L +C +H +++ DE + + + +T Sbjct: 194 SVFSADGDLAPLRDLHAVCRRHGALLLVDEAHGLGVRGTRGQGLLHEVGLAGAPDIVMT- 252 Query: 267 GSAGKSFAATGWRIGWVLSLNA 288 + K+ + G G VL A Sbjct: 253 TTLSKALGSQG---GAVLGPEA 271 >2E7U-A nrPDB Length = 424 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 61/365 (16%), Positives = 110/365 (30%), Gaps = 40/365 (10%) Query: 89 SPTRGRP-SLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLM-GLLNAGDEVIV-F 145 T G P L +L K Y + V E +S L G IV F Sbjct: 84 GLTFGAPSPLEVALAKKVKRAYPF---VDLVRFVNSGTEATMSALRLARGYTGRPYIVKF 140 Query: 146 EPFFDQYIPNIEL---CGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSK---- 198 + + + + G + VP + + D E + + + Sbjct: 141 RGNYHGHADGLLVEAGSGALTLGVPSSAGVPEEYAKLTLVLEYNDPEGLREVLKRRGEEI 200 Query: 199 TKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFT-DSFTRIATLSP 257 + N G + E+ + + V++I+DEV T + L P Sbjct: 201 AAIIFEPVVGN-AGVLVPTEDFLKALHEAKAYGVLLIADEVMTGFRLAFGGATELLGLKP 259 Query: 258 EIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSI 317 ++ L +G + A G R E ++ + + A ++ Sbjct: 260 DLVTLGKILGGGLPAAAYAGRR------EIMEKVAPLGPVYQAGTLSGNPLAMAAGLATL 313 Query: 318 NDALK-IGYFEKMRQEYINKFKIFTSIFDELGLPYTAPE-GTYF-VLVDFSKVKIPEDYP 374 + GY+ + + E GLP+T G+ V V +D Sbjct: 314 ELLEENPGYYAYLEDLGARLEAGLKEVLKEKGLPHTVNRVGSMITVFFTEGPVVTFQDAR 373 Query: 375 YPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAV 434 + L K R H L++ + PP+ F +V + +E + Sbjct: 374 RTDTELFK----RFFHGLLDRG--IYWPPSNFEAAF----------LSVAHREEDVEKTL 417 Query: 435 ERLKL 439 E L+ Sbjct: 418 EALRK 422 >3ECD-A nrPDB Length = 425 Score = 39.4 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 40/295 (13%), Positives = 83/295 (28%), Gaps = 35/295 (11%) Query: 83 PMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEV 142 P Y + I+ ++N NV +GA + + ++ L GD V Sbjct: 65 PGKRYYGGCEFADEVEALAIERVKRLFNAGHA--NVQPHSGA-QANGAVMLALAKPGDTV 121 Query: 143 IVFEPFFDQYIPNIELCGGKVVY--VPINPPKELDQRNTRGEEWT--IDFEQFEKAITSK 198 + GG + + P K + T ID++Q E Sbjct: 122 L----------GMSLDAGGHLTHGAKPALSGKWFNALQYGVSRDTMLIDYDQVEALAQQH 171 Query: 199 TKAVIINTPHNPIGKVFTRE-ELTTLGNICVKHNVVIISDEVY-EHLYFTDSFTRIATLS 256 ++II + R+ + I ++ D + + + Sbjct: 172 KPSLIIAGFS-----AYPRKLDFARFRAIADSVGAKLMVDMAHIAGVIAAGRHANPVEHA 226 Query: 257 PEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANS 316 + + K+ G R G+VL+ + E+ A + + Sbjct: 227 ------HVVTSTTHKTLR--GPRGGFVLTNDEEIAKKINSA-VFPGLQGGPLMHVIAGKA 277 Query: 317 IN-DALKIGYFEKMRQEYINKFKIFTSIFDELGLP-YTAPEGTYFVLVDFSKVKI 369 + F+ + + + G+ T + +LVD + Sbjct: 278 VAFGEALTDDFKTYIDRVLANAQALGDVLKAGGVDLVTGGTDNHLLLVDLRPKGL 332 >3GJU-A nrPDB Length = 460 Score = 38.6 bits (88), Expect = 0.006, Method: Composition-based stats. Identities = 22/156 (14%), Positives = 44/156 (28%), Gaps = 29/156 (18%) Query: 87 QYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVI-VF 145 Y+ GRP + + + + V TG+ G+ V+ Sbjct: 134 YYNNVLGRPEKKKIISRW-RGYHGSG-------VMTGSLTGLDLFHNAFDLPRAPVLHTE 185 Query: 146 EPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIIN 205 P++ + E+ A +T A I Sbjct: 186 APYY------------------FRRTDRSMSEEQFSQHCADKLEEMILAEGPETIAAFIG 227 Query: 206 TPHNPIGKVFTREE--LTTLGNICVKHNVVIISDEV 239 P G + + + K++V++++DEV Sbjct: 228 EPILGTGGIVPPPAGYWEKIQAVLKKYDVLLVADEV 263 >4KAM-A nrPDB Length = 453 Score = 38.6 bits (88), Expect = 0.006, Method: Composition-based stats. Identities = 24/176 (13%), Positives = 50/176 (28%), Gaps = 33/176 (18%) Query: 111 TELKAENVTVTTGANEGILS---------CLMGLLNAGDEVIVFEPFFDQYIPNIELCGG 161 T++ + + G + ++ L AGD ++ + Sbjct: 79 TDVVEQRIAALEGGVAALFLSSGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLA 138 Query: 162 KVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELT 221 K+ + + + ++ A+ TKA T NP + Sbjct: 139 KL------------GIEVSFVDDPDNLDSWQAAVRPNTKAFFGETISNP---QIDLLDTP 183 Query: 222 TLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATG 277 + + ++ + +I D T R T + + V SA K G Sbjct: 184 GVAEVAHRNGIPLIVDN----TIATPYLIRPFTQGAD-----IVVHSATKYLGGHG 230 >1Z7D-A nrPDB Length = 433 Score = 38.3 bits (87), Expect = 0.007, Method: Composition-based stats. Identities = 26/165 (15%), Positives = 56/165 (33%), Gaps = 8/165 (4%) Query: 187 DFEQFEKAI-TSKTKAVIINTPHNPIGKVFTRE-ELTTLGNICVKHNVVIISDEVYEHLY 244 D E E+ + A I+ G + + L + +IC K+NV+ ++DEV L Sbjct: 200 DLEALEEELKDPNVCAFIVEPIQGEAGVIVPSDNYLQGVYDICKKYNVLFVADEVQTGLG 259 Query: 245 FTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFA 304 T + + + +G K+ + + I VL+ N +++ + Sbjct: 260 RTGKL--LCVHHYNVKPDVILLG---KALSGGHYPISAVLA-NDDIMLVIKPGEHGSTYG 313 Query: 305 SPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGL 349 C ++N + E + + + + Sbjct: 314 GNPLAASICVEALNVLINEKLCENAEKLGGPFLENLKRELKDSKI 358 >1SFF-A nrPDB Length = 426 Score = 38.3 bits (87), Expect = 0.007, Method: Composition-based stats. Identities = 26/172 (15%), Positives = 54/172 (31%), Gaps = 9/172 (5%) Query: 216 TREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAA 275 + + L +C +H +++I+DEV T + + + LT S F Sbjct: 218 SPAFMQRLRALCDEHGIMLIADEVQSGAGRTGTLFAMEQMGV-APDLTTFAKSIAGGFPL 276 Query: 276 TGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYIN 335 G ++ AE++ A +A A + + +K Sbjct: 277 AG------VTGRAEVMDAVAPGGLGGTYAGNPIACVAALEVLKVFEQENLLQKANDLGQK 330 Query: 336 KFKIFTSIFDE-LGLPYTAPEGTYFVLVDFSKVKIPE-DYPYPEEILNKGKD 385 +I ++ + G + F + D EI+ + +D Sbjct: 331 LKDGLLAIAEKHPEIGDVRGLGAMIAIELFEDGDHNKPDAKLTAEIVARARD 382 >6JEQ-A nrPDB Length = 675 Score = 37.9 bits (86), Expect = 0.009, Method: Composition-based stats. Identities = 14/64 (21%), Positives = 20/64 (31%), Gaps = 4/64 (6%) Query: 207 PHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTV 266 PHNP ++ EL L + +I D VY H + L P Sbjct: 252 PHNPAARIL---ELKRLIQKLHARGLRVIMDVVYNH-VYDGYLIHFTKLVPGYYLRYKAD 307 Query: 267 GSAG 270 + Sbjct: 308 RTFS 311 >3MC6-C nrPDB Length = 497 Score = 37.9 bits (86), Expect = 0.010, Method: Composition-based stats. Identities = 18/104 (17%), Positives = 38/104 (36%), Gaps = 14/104 (13%) Query: 141 EVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTK 200 E+I + G K+ +V ++P + +D + +K I T Sbjct: 160 EIIAPVTAHAGFDKAAYYFGMKLRHVELDP-----------TTYQVDLGKVKKFINKNTV 208 Query: 201 AVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLY 244 ++ + P+ P G +++ LG I K+ + + D Sbjct: 209 LLVGSAPNFPHGIA---DDIEGLGKIAQKYKLPLHVDSCLGSFI 249 >2FNU-A nrPDB Length = 375 Score = 37.9 bits (86), Expect = 0.010, Method: Composition-based stats. Identities = 30/177 (16%), Positives = 60/177 (33%), Gaps = 31/177 (17%) Query: 70 QFAIKEAQKALDIPMVNQYSPTRGRPSLI--NSLIKLYSPIYNTELKAENVTVTTGANEG 127 + + + K + ++N T+G+ SL+ +L + + V A Sbjct: 8 EPCLDKEDKKAVLEVLNSKQLTQGKRSLLFEEALCEFLGVKHA--------LVFNSATSA 59 Query: 128 ILSCLMGL--LNAGDEVIVFEP-FFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEW 184 +L+ +A I+ P F + G V+ + Sbjct: 60 LLTLYRNFSEFSADRNEIITTPISFVATANMLLESGYTPVF------------AGIKNDG 107 Query: 185 TIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYE 241 ID EK I +TKA++ E+ ++ +C KH++ +SD + Sbjct: 108 NIDELALEKLINERTKAIVSVD------YAGKSVEVESVQKLCKKHSLSFLSDSSHA 158 >3NTJ-A nrPDB Length = 422 Score = 37.5 bits (85), Expect = 0.013, Method: Composition-based stats. Identities = 24/165 (14%), Positives = 55/165 (33%), Gaps = 8/165 (4%) Query: 187 DFEQFEKAI-TSKTKAVIINTPHNPIGKVFTRE-ELTTLGNICVKHNVVIISDEVYEHLY 244 D E EK + A I+ G + + + ++C K+NV+ ++DEV L Sbjct: 181 DLEALEKELQDPNVCAFIVEPVQGEAGVIVPSDSYFPGVASLCKKYNVLFVADEVQTGLG 240 Query: 245 FTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFA 304 T + T + + +G K+ + + I +L+ N +++ + Sbjct: 241 RTGKL--LCTHHYGVKPDVILLG---KALSGGHYPISAILA-NDDVMLVLKPGEHGSTYG 294 Query: 305 SPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGL 349 C ++ + E + + + + Sbjct: 295 GNPLAAAICVEALKVLINEKLCENADKLGAPFLQNLKEQLKDSKV 339 >5VYE-A nrPDB Length = 346 Score = 37.1 bits (84), Expect = 0.014, Method: Composition-based stats. Identities = 42/338 (12%), Positives = 85/338 (25%), Gaps = 40/338 (11%) Query: 75 EAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMG 134 A + + Y G + + ++ T+ + V L Sbjct: 22 AAMEKANHGHDRAY----GDDQWTERASEYFRNLFETDCE---VFFAFNGTAANSLALAS 74 Query: 135 LLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKA 194 L + VI E + CG P + + + Sbjct: 75 LCQSYHSVICSETAHVETDE----CGA-----PEFFSNGSKLLTAASVNGKLTPQSIREV 125 Query: 195 IT-------SKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTD 247 K + V I +G V+ +EL + C + + + D FT+ Sbjct: 126 ALKRQDIHYPKPRVVTITQAT-EVGTVYRPDELKAISATCKELGLNLHMDGA----RFTN 180 Query: 248 SFT----RIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICF 303 + A L+ + G L G G +G + L+ + Sbjct: 181 ACAFLGCSPAELTWKAGVDVLCFGGTKN-----GMAVGEAILFFNRQLAEDFDYRCKQAG 235 Query: 304 ASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAP---EGTYFV 360 S ++ A + + + + D G+ P G + Sbjct: 236 QLASKMRFLSAPWVGLLEDGAWLRHGNHANHCAQLLALLVSDLPGVELMFPVEANGVFLQ 295 Query: 361 LVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGV 398 + + + + + G + W E V Sbjct: 296 MPEHAIEALRAKGWRFYTFIGSGGARFMCSWDTEEERV 333 >3RI6-A nrPDB Length = 430 Score = 37.1 bits (84), Expect = 0.017, Method: Composition-based stats. Identities = 22/124 (17%), Positives = 42/124 (33%), Gaps = 25/124 (20%) Query: 119 TVTTGA-NEGILSCLMGLLNAGDEVIVFEPFF----DQYIPNIELCGGKVVYVPINPPKE 173 + G+ I + ++ L AGD V+ + F + + G +V +V + Sbjct: 100 VLALGSGMAAISTAILTLARAGDSVVTTDRLFGHTLSLFQKTLPSFGIEVRFVDV----- 154 Query: 174 LDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVV 233 +D E A TK + + T NP +L L + + Sbjct: 155 ------------MDSLAVEHACDETTKLLFLETISNP---QLQVADLEALSKVVHAKGIP 199 Query: 234 IISD 237 ++ D Sbjct: 200 LVVD 203 >3I5T-A nrPDB Length = 476 Score = 36.7 bits (83), Expect = 0.018, Method: Composition-based stats. Identities = 65/430 (15%), Positives = 122/430 (28%), Gaps = 72/430 (16%) Query: 51 NQGRELIN----LGQGFFSYSPPQFAIKEAQKALDIPMVN-QYSPTRGRPSLINSLIKLY 105 GR LI+ + Y + A +A+ +P + Y T L + L Sbjct: 51 EDGRRLIDGPAGMWCAQVGYGRREIVDAMAHQAMVLPYASPWYMATSPAARLAEKIATL- 109 Query: 106 SPIYNTELKAENVTVTTGANEGILSCLM-------GLLNAGD-EVIVFEPFFDQYIPNIE 157 T + TTG + + S L L +IV + Sbjct: 110 -----TPGDLNRIFFTTGGSTAVDSALRFSEFYNNVLGRPQKKRIIVRYDGYHGSTALTA 164 Query: 158 LCGGKVVYVP-----------INPPKELDQRNTRGEEWTIDF-EQFEKAI---TSKTKAV 202 C G+ P ++ P N E + D ++FE I T A Sbjct: 165 ACTGRTGNWPNFDIAQDRISFLSSPNPRHAGNRSQEAFLDDLVQEFEDRIESLGPDTIAA 224 Query: 203 IINTPHNPIGKVF--TREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIG 260 + P G V IC KH+++ ISDEV + + + Sbjct: 225 FLAEPILASGGVIIPPAGYHARFKAICEKHDILYISDEVVTGFGRCGEWFASEKVFGVVP 284 Query: 261 QLTLTVGSAGKSFAATGWRIGWV----LSLNAELLSYAA---KAHTRICFASPSPLQEAC 313 + + K G G+V L+++ +L+ + + Q Sbjct: 285 D----IITFAK-----GVTSGYVPLGGLAISEAVLARISGENAKGSWFTNGYTYSNQPVA 335 Query: 314 ANSINDALKIGYFEKMRQEYINKFKIFTSIF----DELGLPYTAPEGTYFVLVDFSKVKI 369 + +++ E + + F + D G+ T G + Sbjct: 336 CAAALANIELMEREGIVDQAREMADYFAAALASLRDLPGVAETRSVGLVGCVQCLLDPTR 395 Query: 370 PEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAY 429 + + K + ELG++ P + + + A Sbjct: 396 ADGTAEDKAFTLKIDERCF------ELGLIVRPLGDLCVISPP----------LIISRAQ 439 Query: 430 LENAVERLKL 439 ++ V ++ Sbjct: 440 IDEMVAIMRQ 449 >3HQT-A nrPDB Length = 409 Score = 36.7 bits (83), Expect = 0.020, Method: Composition-based stats. Identities = 45/329 (13%), Positives = 102/329 (31%), Gaps = 51/329 (15%) Query: 116 ENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELD 175 + ++ + L + V + D + G + +P + Sbjct: 120 DECLLSQSGWNANVGLLQTICQPNTNVYI-----DFFAHMSLWEGARYANAQAHPFMHNN 174 Query: 176 QRNTRGEEWTIDFEQFEKAITSKTKAVIIN-TPHNPIGKVFTREELTTLGNICVKHNVVI 234 + I +I+ + ++ +G + L L NI + + Sbjct: 175 C------------DHLRMLIQRHGPGIIVVDSIYSTLGTIAP---LAELVNISKEFGCAL 219 Query: 235 ISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYA 294 + DE + + + ++ S K+FA +R G + N ++ Sbjct: 220 LVDESHSLGTHGPNGAGLLAELGLTREVHFMTASLAKTFA---YRAGAIWCNNE--VNRC 274 Query: 295 AKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSI-FDELGLPYTA 353 + S + L A + L+I R++++++ I +LGL Sbjct: 275 VPFISYPAIFSSTLLPYEAA-GLETTLEIIESADNRRQHLDRMARKLRIGLSQLGLTIR- 332 Query: 354 PEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEK 413 S+ +I E K +D+ + GV + F K Sbjct: 333 -----------SESQIIGLETGDERNTEKVRDY------LESNGVF---GSVFCRPATSK 372 Query: 414 AAENLLRFAVCKDDAYLENAVERLKLLKD 442 +N++R ++ D E + +++ D Sbjct: 373 N-KNIIRLSL-NSDVNDEQIAKIIEVCSD 399 >2VYC-A nrPDB Length = 755 Score = 36.7 bits (83), Expect = 0.020, Method: Composition-based stats. Identities = 34/265 (12%), Positives = 75/265 (28%), Gaps = 28/265 (10%) Query: 103 KLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGK 162 K + ++ + ++ +V V G + + + + D V+V + L G K Sbjct: 212 KYAARVFGAD-RSWSVVV--GTSGSNRTIMQACMTDNDVVVVDRNCHKSIEQGLMLTGAK 268 Query: 163 VVY-VPINPPKELDQRNTRGEEWTIDFEQ------FEKAITSKTKAVIINTPHNPI--GK 213 VY VP + E ++ K + + + T N G Sbjct: 269 PVYMVPSRNRYGIIGPIYPQEMQPETLQKKISESPLTKDKAGQKPSYCVVT--NCTYDGV 326 Query: 214 VFTREELTTLGNICVKHNVVIISDEVYEHL-----YFTDSFTRIATLSPEIGQLTLTVGS 268 + +E L K + + DE + + D + G S Sbjct: 327 CYNAKEAQDLLE---KTSDRLHFDEAWYGYARFNPIYADHYAMRGEPGDHNGPTVFATHS 383 Query: 269 AGKSFAATGW------RIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALK 322 K A R G + T + + + ++ Sbjct: 384 THKLLNALSQASYIHVREGRGAINFSRFNQAYMMHATTSPLYAICASNDVAVSMMDGNSG 443 Query: 323 IGYFEKMRQEYINKFKIFTSIFDEL 347 + +++ E ++ + ++ E Sbjct: 444 LSLTQEVIDEAVDFRQAMARLYKEF 468 >5LH9-A nrPDB Length = 458 Score = 36.7 bits (83), Expect = 0.021, Method: Composition-based stats. Identities = 44/305 (14%), Positives = 86/305 (28%), Gaps = 62/305 (20%) Query: 75 EAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAE--NVTVTTGANEGILSCL 132 +A A + + Y G + L + + V ++G ++ + + L Sbjct: 75 KAAIAAQLDELAYYQTFDGIAHPR--VFDLAERLTGMFAQERMARVLFSSGGSDAVETAL 132 Query: 133 M-------GLLNAGD-EVIVFEPFFDQ---------------YIPNIELCGGKVVYVPIN 169 G + + Y L G ++ P Sbjct: 133 KMARQYWIASGEPGRTRFLSLRNGYHGVHMGGTSVGGNGVYHYNHGQLLAGCHLLDTPWL 192 Query: 170 PPKELDQRNTRGEEWTIDFEQFEKAIT---SKTKAVIINTPHNPIGKVF--TREELTTLG 224 D R+ + Q E+ I ++T A +I P G V + L Sbjct: 193 YRNPWDCRDPQALTAHC-IRQLEEQIALLGAQTIAALIAEPVQGAGGVIVPPADYWPRLR 251 Query: 225 NICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVL 284 +C +H +++I+DEV V G+S G R GW + Sbjct: 252 EVCDRHGILLIADEV--------------------------VTGFGRSGCMLGSR-GWGV 284 Query: 285 SLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIF 344 + + +L A + + A++I + + Y + Sbjct: 285 APD--ILCLAKGITAGYIPLGATLFNQRIADAIENGQGFSHMIMHGYTYSGHPTACAAAL 342 Query: 345 DELGL 349 L + Sbjct: 343 AVLDI 347 >5M46-A nrPDB Length = 440 Score = 36.7 bits (83), Expect = 0.021, Method: Composition-based stats. Identities = 34/216 (15%), Positives = 63/216 (29%), Gaps = 25/216 (11%) Query: 44 KAANNSKNQGRELINL----GQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLIN 99 + A + GRELI+L G Y P I+ +A P P++ Sbjct: 34 QGARLVEEDGRELIDLSGAWGAASLGYGHP-AIIEAVSRAAANPAGASILSASNAPAVAL 92 Query: 100 SLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEP------------ 147 + +L + V ++ + + A V Sbjct: 93 A-ERLTASFPGRGTHK--VWFGHSGSDANEAAYRAITRATGRTGVIAFIGAYHGCTVGSM 149 Query: 148 FFDQYI---PNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVII 204 F + + G ++ P +P + T + E+ A I Sbjct: 150 AFSGHSVQADAAKADGLILLPYP-DPYRPYQDDPTGDAVLALLKERLAAVPAGSIAAAFI 208 Query: 205 NTPHNPIGKVFTRE-ELTTLGNICVKHNVVIISDEV 239 + G + + L +IC H + ++ DEV Sbjct: 209 EPIQSDGGLIVPPDGFLRKFADICRAHGISVVCDEV 244 >3HBX-A nrPDB Length = 502 Score = 36.3 bits (82), Expect = 0.029, Method: Composition-based stats. Identities = 46/363 (12%), Positives = 96/363 (26%), Gaps = 65/363 (17%) Query: 27 TSNTAKDVWSLTNEAAAKAANNSKNQGRELIN---LGQGFFSYSPPQFAIK----EAQKA 79 ++ ++ V + + K ++IN + G + F E K Sbjct: 16 STFASRYVRTSLPRFKMPENSIPKEAAYQIINDELMLDGNPRLNLASFVTTWMEPECDKL 75 Query: 80 LDIPMVNQYSPTRGRP---SLINSLIKLYSPIYNTELKAENVTV---TTGANEGILSCLM 133 + + Y P L N + + + ++N L+ V T G++E I+ + Sbjct: 76 IMSSINKNYVDMDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVGVGTVGSSEAIMLAGL 135 Query: 134 GL-----------LNAGD--EVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTR 180 D ++ + ++ V ++ Sbjct: 136 AFKRKWQNKRKAEGKPVDKPNIVTGANVQVCWEKFARYFEVELKEVKLSEGY-------- 187 Query: 181 GEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFT--REELTTLGNICVKH------NV 232 + +D +Q + T V +G E++ L ++ V+ + Sbjct: 188 ---YVMDPQQAVDMVDENTICVAAI-----LGSTLNGEFEDVKLLNDLLVEKNKETGWDT 239 Query: 233 VIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLS 292 I D + + ++ V G IGWV+ N E L Sbjct: 240 PIHVDAASGGFIAPFLYPELEWDFRLPLVKSINVSGHKYGLVYAG--IGWVIWRNKEDLP 297 Query: 293 YAAKAH-TRICFASPS------------PLQEACANSINDALKIGYFEKMRQEYINKFKI 339 H + P+ Q + E R+ I + Sbjct: 298 EELIFHINYLGADQPTFTLNFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLREG 357 Query: 340 FTS 342 Sbjct: 358 LEK 360 >2QMA-A nrPDB Length = 497 Score = 36.3 bits (82), Expect = 0.029, Method: Composition-based stats. Identities = 20/167 (11%), Positives = 50/167 (29%), Gaps = 15/167 (8%) Query: 99 NSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMG----LLNAGDEVIVFEPFFDQYIP 154 ++ Y+ KA+ + T+G + LM + + + + Y Sbjct: 143 QKVVNWLCDKYDLSEKADGI-FTSGGTQSNQMGLMLARDWIADKLSGHSIQKLGLPDYAD 201 Query: 155 NIELCGGKVVYVPINPPKELDQRNTRG-------EEWTIDFEQFEKAITSKTKAVIINTP 207 + + K + + + + T+D + ++ I +I Sbjct: 202 KLRIVCSKKSHFTVQKSASWMGLGEKAVMTVDANADGTMDITKLDEVIAQAKAEGLIPFA 261 Query: 208 HNPIGKVFTR---EELTTLGNICVKHNVVIISDEVYEHLYFTDSFTR 251 ++L + ++ VKH++ + D Y S Sbjct: 262 IVGTAGTTDHGAIDDLDFIADMAVKHDMWMHVDGAYGGALILSSHKS 308 >1VJO-A nrPDB Length = 393 Score = 35.9 bits (81), Expect = 0.033, Method: Composition-based stats. Identities = 26/174 (14%), Positives = 63/174 (36%), Gaps = 17/174 (9%) Query: 67 SPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANE 126 P A +A+++ V P +L++ + L ++ TE + V+ Sbjct: 40 PGPSNAHPSVLQAMNVSPVGHLDPAF--LALMDEIQSLLRYVWQTE-NPLTIAVSGTGTA 96 Query: 127 GILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTI 186 + + + + GD V++ + G ++V + ++ + E Sbjct: 97 AMEATIANAVEPGDVVLIGVAGY---------FGNRLVDMAGRYGADVRTISKPWGE-VF 146 Query: 187 DFEQFEKAI-TSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEV 239 E+ A+ T + + + G R+ L +G +C + +++ D V Sbjct: 147 SLEELRTALETHRPAILALVHAETSTGA---RQPLEGVGELCREFGTLLLVDTV 197 >4ISY-A nrPDB Length = 404 Score = 35.9 bits (81), Expect = 0.038, Method: Composition-based stats. Identities = 21/157 (13%), Positives = 40/157 (25%), Gaps = 30/157 (19%) Query: 94 RPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGL------LNAGDEVIV--- 144 + V T G E + G+ IV Sbjct: 55 IEEARELIADKLGAR------PSEVIFTAGGTESDNLAVKGIYWARRDAEPHRRRIVTTE 108 Query: 145 --FEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAV 202 D +E G V ++P + R + D V Sbjct: 109 VEHHAVLDSVNWLVEHEGAHVTWLPTAADGSVSATALREALQSHD----------DVALV 158 Query: 203 IINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEV 239 + +N +G + E++ + ++ V + SD + Sbjct: 159 SVMWANNEVGTILPIAEMSVV---AMEFGVPMHSDAI 192 >3HL2-A nrPDB Length = 501 Score = 35.6 bits (80), Expect = 0.051, Method: Composition-based stats. Identities = 25/171 (14%), Positives = 53/171 (30%), Gaps = 12/171 (7%) Query: 166 VPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTR---EELTT 222 + + + G+E D + E + I+ F + L Sbjct: 180 ITAGFEPVVIENVLEGDELRTDLKAVEAKVQELGPDCILCIHS--TTSCFAPRVPDRLEE 237 Query: 223 LGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIG- 281 L IC +++ I + Y + + +G++ V S K+F +G Sbjct: 238 LAVICANYDIPHIVNNAYG--VQSSKCMHLIQQGARVGRIDAFVQSLDKNFMVP---VGG 292 Query: 282 -WVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQ 331 + N + +K + ASPS S+ ++ ++ Sbjct: 293 AIIAGFNDSFIQEISKMYPGRASASPSLDVLITLLSLGSNGYKKLLKERKE 343 >3FCR-A nrPDB Length = 458 Score = 35.2 bits (79), Expect = 0.053, Method: Composition-based stats. Identities = 22/156 (14%), Positives = 45/156 (28%), Gaps = 29/156 (18%) Query: 87 QYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVI-VF 145 Y+ GRP + + + + L TG+ G+ ++VI Sbjct: 133 YYNNILGRPEKKKIISRW-RGYHGSGL-------VTGSLTGLELFHKKFDLPVEQVIHTE 184 Query: 146 EPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIIN 205 P++ + E + + T A I Sbjct: 185 APYY------------------FRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIG 226 Query: 206 TPHNPIGKVFTREE--LTTLGNICVKHNVVIISDEV 239 P G + + + KH++++++DEV Sbjct: 227 EPILGTGGIVPPPAGYWEAIQTVLNKHDILLVADEV 262 >4PPM-A nrPDB Length = 861 Score = 35.2 bits (79), Expect = 0.056, Method: Composition-based stats. Identities = 33/244 (13%), Positives = 73/244 (29%), Gaps = 29/244 (11%) Query: 43 AKAANNSKNQGRELINLGQGFFSYS---PPQFAIKEAQKALDIPMVN--QYSPTRGRPSL 97 A + G +++ G+ + PQ + + LD N QY P Sbjct: 422 AAGTQLYDDAGEAFLDMVAGYGCLNLGHNPQPVVNALKNYLDAQGPNFIQYIS---IPEQ 478 Query: 98 INSLIKLYSPIYNTELKAENVTVTTGANEGILSCL----MGLLNAGDEVIVFEPFFDQ-Y 152 L ++ + + V + E + + + G + + Sbjct: 479 TAKLAEVLCRLAPGNMG--RVFFSNSGTEAVEAAMKIAKASTGKPG--IAYLRNSYHGKT 534 Query: 153 IPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSK-TKAVIINTPHNPI 211 + + + G P + G D +A+ + A++I Sbjct: 535 LGALSITGRDKHRRYFTPLLDAMVEVPFG-----DLAALREALNREDVGALMIEPIQGEG 589 Query: 212 GKVFTRE-ELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAG 270 G L + +C + V+++ DEV L T ++ + + + + Sbjct: 590 GVHIPPAGYLQAVQQLCRETGVLLMVDEVQTGLGRTG---KLFACEWDGIEPDVLM--LS 644 Query: 271 KSFA 274 KS + Sbjct: 645 KSLS 648 >3L44-A nrPDB Length = 434 Score = 35.2 bits (79), Expect = 0.063, Method: Composition-based stats. Identities = 51/306 (16%), Positives = 91/306 (29%), Gaps = 42/306 (13%) Query: 140 DEVIVFEPFFDQYIPNIELCGG------KVVYVPINPPKELDQRNTRGEEWTIDFEQFEK 193 D V+V + + G +V+ VP N + L + + E Sbjct: 152 DLVLVAAGSGPSTLGTPDSAGVPQSIAQEVITVPFNNVETLKEALDKWGH-----EVAAI 206 Query: 194 AITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFT-DSFTRI 252 + I P L + + + ++I DEV F + Sbjct: 207 LVEPIVGNFGIVEP--------KPGFLEKVNELVHEAGALVIYDEVITAFRFMYGGAQDL 258 Query: 253 ATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSY---AAKAHTRICFASPSPL 309 ++P++ L +G G IG E++ A+ A Sbjct: 259 LGVTPDLTALGKVIGG--------GLPIG-AYGGKKEIMEQVAPLGPAYQAGTMAGNPAS 309 Query: 310 QEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYT--APEGTYFVLVDFSKV 367 + + + G +EK+ + K + + T +G V + + Sbjct: 310 MASGIACLEVLQQEGLYEKLDELGATLEKGILEQAAKHNIDITLNRLKGALTVYFTTNTI 369 Query: 368 KIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTE---FYIKEHEKAAENLLRFAVC 424 EDY ++ G+ F L+ + GV P F EH K AV Sbjct: 370 ---EDYDAAQD--TDGEMFGKFFKLMLQEGVNLAPSKYEAWFLTTEHTKEDIEYTIEAVG 424 Query: 425 KDDAYL 430 + A L Sbjct: 425 RAFAAL 430 >3BC8-A nrPDB Length = 450 Score = 34.8 bits (78), Expect = 0.080, Method: Composition-based stats. Identities = 30/187 (16%), Positives = 60/187 (32%), Gaps = 16/187 (8%) Query: 166 VPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTR---EELTT 222 V + + G+E D + E I I+ F + L Sbjct: 162 VTAGFEPVVIENVLEGDELRTDLKAVEAKIQELGPEHILCLHS--TTACFAPRVPDRLEE 219 Query: 223 LGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIG- 281 L IC +++ + + Y + + +G++ V S K+F +G Sbjct: 220 LAVICANYDIPHVVNNAYG--LQSSKCMHLIQQGARVGRIDAFVQSLDKNFMVP---VGG 274 Query: 282 -WVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIF 340 + N + +K AS SP + + +L + K+ +E F Sbjct: 275 AIIAGFNEPFIQDISK--MYPGRASASPSLDVLITLL--SLGCSGYRKLLKERKEMFVYL 330 Query: 341 TSIFDEL 347 ++ +L Sbjct: 331 STQLKKL 337 >6G4F-A nrPDB Length = 464 Score = 34.8 bits (78), Expect = 0.081, Method: Composition-based stats. Identities = 35/228 (15%), Positives = 67/228 (29%), Gaps = 35/228 (15%) Query: 52 QGRELIN----LGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSP 107 QG+ I L +S + Q+ +P + +S RPS+ L + Sbjct: 46 QGKGYIEAMAGLWSAALGFSNQRLIKAAEQQFNTLPFYHLFSHKSHRPSI--ELAEKLIE 103 Query: 108 IYNTELKAENVTVTTGANEGILSCLM-------GLLNAGDEVIVFE-PFF---------- 149 + + V T +E + + L + + + Sbjct: 104 MAPVPMSK--VFFTNSGSEANDTVVKMVWYLNNALGKPAKKKFISRVNGYHGITVASASL 161 Query: 150 ---DQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFE-QFEKAI---TSKTKAV 202 +L ++V E + + E+ I +T A Sbjct: 162 TGLPGNQRGFDLPLPGFLHVGCPHHYRFALAGESEEHFADRLAVELEQKILAEGPETIAA 221 Query: 203 IINTPHNPIGKVF--TREELTTLGNICVKHNVVIISDEVYEHLYFTDS 248 I P G V R + +C K+++++I+DEV T Sbjct: 222 FIGEPLMGAGGVIVPPRTYWEKIQKVCRKYDILVIADEVICGFGRTGQ 269 >6GWI-A nrPDB Length = 462 Score = 34.8 bits (78), Expect = 0.086, Method: Composition-based stats. Identities = 50/367 (13%), Positives = 110/367 (29%), Gaps = 44/367 (11%) Query: 57 INLGQGFFSYSPPQFAIKEAQKALD-IPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKA 115 +NLG G + ++ A L+ +P N + T P++ L + + + Sbjct: 59 VNLGYGR------RELVEAATAQLEQLPYYNTFFKTTHPPAVR--LAEKLCDLAPAHI-- 108 Query: 116 ENVTVTTGANEGILSCLM------GLLNAGDE--VIVFEPFFD-QYIPNIELCGGKVVY- 165 V T +E + L L D+ +I E + + + L G ++ Sbjct: 109 NRVFFTGSGSEANDTVLRMVRRYWALKGQPDKQWIIGRENAYHGSTLAGMSLGGMAPMHA 168 Query: 166 -----VPINPPKELDQRNTRGEEWTIDF------EQFEKAI----TSKTKAVIINTPHNP 210 VP G + + + E E+ I K A I Sbjct: 169 QGGPCVPGIAHIRQPYWFGEGRDMSPEAFGQTCAEALEEKILELGEEKVAAFIAEPVQGA 228 Query: 211 IGKVFTRE-ELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSA 269 G + E + + K+++++++DEV + E L Sbjct: 229 GGAIMPPESYWPAVKKVLAKYDILLVADEVICGFGRLGEWFGSQHYGLE-PDLMPIAKGL 287 Query: 270 GKSFAATGWRIGWVLSLN--AELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFE 327 + G G ++ L+ + ++ ++ G + Sbjct: 288 SSGYLPIG---GVLVGDRVAETLIEEGGEFFHGFTYSGHPTCAAVALKNLELLEAEGVVD 344 Query: 328 KMRQEYINKF-KIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDF 386 ++R + + + S+ D + G L + + + N +D Sbjct: 345 RVRDDLGPYLAERWASLVDHPIVGEARSLGLMGALELVADKTTGQRFDKSLGAGNLCRDL 404 Query: 387 RISHWLI 393 ++ L+ Sbjct: 405 CFANGLV 411 >4E3Q-A nrPDB Length = 473 Score = 34.4 bits (77), Expect = 0.096, Method: Composition-based stats. Identities = 22/158 (13%), Positives = 44/158 (27%), Gaps = 26/158 (16%) Query: 112 ELKAENVTVTTGANEGILSCLMGL----LNAGD----EVIVFEPFFDQYIPNIELCGGKV 163 + V T +E + + L G +++ + GK Sbjct: 125 PFDSGRVFYTNSGSEANDTMVKMLWFLHAAEGKPQKRKILTRWNAYHGVTAVSASMTGKP 184 Query: 164 ------------VYVPINPPKELDQRNTRGEEWTIDFE-QFEKAITSKTKAVIINTPHNP 210 V++ + E++ + E+ I + I P Sbjct: 185 YNSVFGLPLPGFVHLTCPHYWRYGEEGETEEQFVARLARELEETIQREGADTIAGFFAEP 244 Query: 211 I---GKVFTRE--ELTTLGNICVKHNVVIISDEVYEHL 243 + G V + I K+++ +ISDEV Sbjct: 245 VMGAGGVIPPAKGYFQAILPILRKYDIPVISDEVICGF 282 >4WXB-A nrPDB Length = 428 Score = 34.4 bits (77), Expect = 0.099, Method: Composition-based stats. Identities = 36/266 (13%), Positives = 78/266 (29%), Gaps = 24/266 (9%) Query: 83 PMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEV 142 P Y T + I+ ++ + NV +G+ + + M L+ GD V Sbjct: 72 PGKRYYGGTAVIDVVETLAIERAKKLFGAKFA--NVQPHSGS-QANAAVYMSLIQPGDTV 128 Query: 143 IVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAV 202 + + ++ G V + N E +D++ + Sbjct: 129 MGMDLSAGGHLT----HGAPVSF--SGKTYNFVSYNVDKESELLDYDAILAQAKEVRPKL 182 Query: 203 IINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVY-EHLYFTDSFTRIATLSPEIGQ 261 I+ + I ++ D + L + + Sbjct: 183 IVAGAS----AYSRIIDFAKFREIADAVGAYLMVDMAHIAGLVASGHHPSPVPYAHVTTT 238 Query: 262 LTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASP-SPLQEACANSINDA 320 T K+ G R G +L+ + ++ A P + A A ++ +A Sbjct: 239 TTH------KTLR--GPRGGLILTDDEDIAKKLNSAVFPGLQGGPLEHVIAAKAVALKEA 290 Query: 321 LKIGYFEKMRQEYINKFKIFTSIFDE 346 L F++ + I +F++ Sbjct: 291 LDPA-FKEYGENVIKNAAAMADVFNQ 315 >5KR3-A nrPDB Length = 479 Score = 34.4 bits (77), Expect = 0.10, Method: Composition-based stats. Identities = 25/147 (17%), Positives = 49/147 (33%), Gaps = 10/147 (6%) Query: 189 EQFEKAITSK---TKAVIINTPHNPIGKVFTREE--LTTLGNICVKHNVVIISDEVYEHL 243 E+ EK I + T A I P G + + + + KH++++I+DEV Sbjct: 226 EELEKLIAREGADTIAAFIAEPVMGTGGIIPPPQGYWEAIQAVLRKHDILLIADEVVCGF 285 Query: 244 YFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNA-ELLSYAAKAHTRIC 302 S + L ++A G ++ +++ ++ H + Sbjct: 286 GRLGSKMGSQHYGIK-PDLITVAKGLTSAYAPL---SGVIVGEKVWDVIEKGSQEHGPMG 341 Query: 303 FASPSPLQEACANSINDALKIGYFEKM 329 CA + L I E + Sbjct: 342 HGWTYSGHPICAAAALANLDILERENL 368 >5VIU-A nrPDB Length = 419 Score = 34.4 bits (77), Expect = 0.11, Method: Composition-based stats. Identities = 26/163 (15%), Positives = 51/163 (31%), Gaps = 7/163 (4%) Query: 188 FEQFEKAITSKTKAVIINTPHNPIGKVFTRE-ELTTLGNICVKHNVVIISDEVYEHLYFT 246 E+ A ++ G E L +C KHNV+ I+DEV + T Sbjct: 190 LEEVLSKEAGNIAAFLVEPIQGEAGVYVPNEGFLKQSSELCKKHNVLFIADEVQTGIART 249 Query: 247 DSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASP 306 IA ++ L +G K+ + + + VL+ N ++ F Sbjct: 250 GKL--IACHHEDVQPDILILG---KALSGGMYPVSAVLANN-NIMDVIKPGQHGSTFGGN 303 Query: 307 SPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGL 349 +++ E+ + + ++ L Sbjct: 304 PLACAVAMAALDVVQDEKLSERAEKLGNLFRSEIEKLIEKTDL 346 >4RIT-B nrPDB Length = 486 Score = 34.0 bits (76), Expect = 0.13, Method: Composition-based stats. Identities = 21/148 (14%), Positives = 38/148 (25%), Gaps = 23/148 (15%) Query: 119 TVTTGANEGILSCLMG-------LLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPP 171 +T+G + L L + G + P + + + Sbjct: 149 VLTSGGSLANLQALAVARNVAFDSVEPGITGLAQRPVIFASEAAHTSLQKAAMLLGLGTA 208 Query: 172 KELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNP--------IGKVFTREELTTL 223 + R T +D E I A +P + L + Sbjct: 209 AVIPVRATADS--RMDPEDLRARIDQARGA-----GQHPFCVVATAGTTTTGNIDPLAEI 261 Query: 224 GNICVKHNVVIISDEVYEH-LYFTDSFT 250 G I +H + D Y L F++ Sbjct: 262 GAIAREHGLWFHVDAAYGGALVFSERHR 289 >2CH1-A nrPDB Length = 396 Score = 34.0 bits (76), Expect = 0.13, Method: Composition-based stats. Identities = 42/258 (16%), Positives = 82/258 (31%), Gaps = 48/258 (18%) Query: 119 TVTTGANEGILSCLMGLLNAGDEVIVFEPF--FDQYIPNIELCGGKVVYVPINPPKELDQ 176 V+ A+ G+ + L LL GD V++ ++ + E G V + P + Sbjct: 73 CVSGSAHAGMEAMLSNLLEEGDRVLIAVNGIWAERAVEMSERYGADVRTIEGPPDRPF-- 130 Query: 177 RNTRGEEWTIDFEQFEKAIT-SKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVII 235 E +AI + K + + + G + L +G IC +H+ ++I Sbjct: 131 ----------SLETLARAIELHQPKCLFLTHGDSSSGLLQP---LEGVGQICHQHDCLLI 177 Query: 236 SDEV--------YE-----HLYFTDSFT--------RIATLSPEIGQLTLTVGSAGKSFA 274 D V Y +T + ++SP+ + + K F Sbjct: 178 VDAVASLCGVPFYMDKWEIDAVYTGAQKVLGAPPGITPISISPKALDVIRNRRTKSKVFY 237 Query: 275 ATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYI 334 +G E Y + + FA L + + + + + I Sbjct: 238 WDLLLLGNYWGCYDEPKRYHHTVASNLIFALREALAQIAEEGLENQI---------KRRI 288 Query: 335 NKFKIFTSIFDELGLPYT 352 +I ++GL Sbjct: 289 ECAQILYEGLGKMGLDIF 306 >2Z9W-A nrPDB Length = 392 Score = 34.0 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 37/231 (16%), Positives = 66/231 (28%), Gaps = 33/231 (14%) Query: 48 NSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSP 107 +I L G P A E + L ++ Y P L ++ Sbjct: 2 RYPEHADPVITLTAG------PVNAYPEVLRGLGRTVLYDYDPAFQL--LYEKVVDKAQK 53 Query: 108 IYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVP 167 K V + G+ + L++ D V+ + G Y Sbjct: 54 AMRLSNKP--VILHGEPVLGLEAAAASLISPDDVVL---------NLASGVYGKGFGYWA 102 Query: 168 INPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHN--PIGKVFTREELTTLGN 225 L + E ID + + + + +++ H+ P G + + +G Sbjct: 103 KRYSPHLLEIEVPYNE-AIDPQAVADMLKAHPEITVVSVCHHDTPSGTINPID---AIGA 158 Query: 226 ICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAAT 276 + H +I D V F T PE + + V K A Sbjct: 159 LVSAHGAYLIVDAVSS---FGGMKTH-----PEDCKADIYVTGPNKCLGAP 201 >4BA4-A nrPDB Length = 459 Score = 34.0 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 37/229 (16%), Positives = 77/229 (33%), Gaps = 34/229 (14%) Query: 51 NQGRELIN----LGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYS 106 ++G ++I+ L Y FA ++ ++P N + T P+++ L L + Sbjct: 47 SEGNKIIDGMAGLWCVNVGYGRKDFAEAARRQMEELPFYNTFFKTT-HPAVVE-LSSLLA 104 Query: 107 PIYNTELKAENVTVTTGANEGILSCLMGLL-------NAGDEVIVF-EPFFD-QYIPNIE 157 + + V T +E + + + + + ++ + I Sbjct: 105 EVTPAGF--DRVFYTNSGSESVDTMIRMVRRYWDVQGKPEKKTLIGRWNGYHGSTIGGAS 162 Query: 158 LCGGKV------VYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAV--------- 202 L G K + +P E G++ T D A + K + Sbjct: 163 LGGMKYMHEQGDLPIPGMAHIEQPWWYKHGKDMTPDEFGVVAARWLEEKILEIGADKVAA 222 Query: 203 IINTPHNPIGKVF--TREELTTLGNICVKHNVVIISDEVYEHLYFTDSF 249 + P G V + IC K++V++++DEV T + Sbjct: 223 FVGEPIQGAGGVIVPPATYWPEIERICRKYDVLLVADEVICGFGRTGEW 271 >5KQU-A nrPDB Length = 479 Score = 34.0 bits (76), Expect = 0.15, Method: Composition-based stats. Identities = 20/96 (20%), Positives = 33/96 (34%), Gaps = 4/96 (4%) Query: 147 PFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTID-FEQFEKAITSKTKAVIIN 205 P F Q+ + G K P + D E+ A T A I Sbjct: 187 PSFHQHFDLP-VEGIKHTVCPHWYKAPAGMDEAAFVRYCADELEKLILAEGPDTVAAFIG 245 Query: 206 TPHNPIGKVF--TREELTTLGNICVKHNVVIISDEV 239 P G + + + + K++V++I+DEV Sbjct: 246 EPVMGTGGIIVPPKGYWEAIQAVLNKYDVLLIADEV 281 >1DJ9-A nrPDB Length = 384 Score = 33.6 bits (75), Expect = 0.17, Method: Composition-based stats. Identities = 16/129 (12%), Positives = 45/129 (34%), Gaps = 7/129 (5%) Query: 220 LTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWR 279 L + + +HN ++ D+ + + L +L + + GK F +G Sbjct: 187 LAEIQQVTQQHNGWLMVDDAHGTGVIGEQGRGSCWLQKVKPELLVV--TFGKGFGVSGA- 243 Query: 280 IGWVLSLNAELLSYAAKAHTRICFASP-SPLQEACANSINDALKIGYFEKMRQEYINKFK 338 + ++ + Y + + +++ P Q + ++ + R++ Sbjct: 244 ---AVLCSSTVADYLLQFARHLIYSTSMPPAQAQALRASLAVIRSDEGDARREKLAALIT 300 Query: 339 IFTSIFDEL 347 F + +L Sbjct: 301 RFRAGVQDL 309 >2DGM-A nrPDB Length = 466 Score = 33.6 bits (75), Expect = 0.19, Method: Composition-based stats. Identities = 31/239 (12%), Positives = 66/239 (27%), Gaps = 35/239 (14%) Query: 121 TTGANEGILSCLMGL-----------LNAGDEV-IVFEPFFDQYIPNIELCGGKVVYVPI 168 T G++E + M + D+ +V P + ++ +P+ Sbjct: 123 TIGSSEACMLGGMAMKWRWRKRMEAAGKPTDKPNLVCGPVQICWHKFARYWDVELREIPM 182 Query: 169 NPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKV-FTREELTTLGNIC 227 P + +D ++ +A T V+ G F + L Sbjct: 183 RPGQLF-----------MDPKRMIEACDENTIGVVPTFGVTYTGNYEFPQPLHDALDKFQ 231 Query: 228 VKHNVVI--ISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLS 285 + I D F + ++ ++G F GWV+ Sbjct: 232 ADTGIDIDMHIDAASGGFL--APFVAPDIVWDFRLPRVKSISASGHKFGLAPLGCGWVIW 289 Query: 286 LNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIG-YFEKMRQEYINKFKIFTSI 343 + E L + F + +IN + G + + + +T + Sbjct: 290 RDEEALP------QELVFNVDYLGGQIGTFAINFSRPAGQVIAQYYEFLRLGREGYTKV 342 >5KQW-A nrPDB Length = 479 Score = 33.6 bits (75), Expect = 0.20, Method: Composition-based stats. Identities = 23/147 (15%), Positives = 48/147 (32%), Gaps = 10/147 (6%) Query: 189 EQFEKAI---TSKTKAVIINTPHNPIGKVFTREE--LTTLGNICVKHNVVIISDEVYEHL 243 ++ EK I T A I P G + + + + K+++++I+DEV Sbjct: 226 DELEKLILAEGPDTVAAFIGEPVMGTGGIIPPPQGYWEAIQAVLNKYDILLIADEVVCGF 285 Query: 244 YFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNA-ELLSYAAKAHTRIC 302 S + L ++A G ++ +++ ++ H + Sbjct: 286 GRLGSKMGSQHYGMK-PDLITVAKGLTSAYAPL---SGVIVGEKVWDVIEKGSQEHGPMG 341 Query: 303 FASPSPLQEACANSINDALKIGYFEKM 329 CA + L I E + Sbjct: 342 HGWTYSGHPICAAAALANLDILERENL 368 >5KR5-A nrPDB Length = 479 Score = 33.2 bits (74), Expect = 0.23, Method: Composition-based stats. Identities = 26/148 (17%), Positives = 50/148 (33%), Gaps = 12/148 (8%) Query: 189 EQFEKAITSK---TKAVIINTPHNPIGKVFTREE--LTTLGNICVKHNVVIISDEVYEHL 243 E+ EK I + T A I P G + + + + KH++++I+DEV Sbjct: 226 EELEKLIAREGADTIAAFIAEPVMGTGGIVPPPQGYWEAIQAVLRKHDILLIADEVVCGF 285 Query: 244 YFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNA--ELLSYAAKAHTRI 301 S T + L ++A + V+ +++ ++ H + Sbjct: 286 GRLGSKTGSEHYGIK-PDLITVAKGLTSAYAP----LSAVIVSEKVWDVIEKGSREHGVM 340 Query: 302 CFASPSPLQEACANSINDALKIGYFEKM 329 CA + L I E + Sbjct: 341 GHGWTYSGHPVCAAAALANLDILERENL 368 >2HUU-A nrPDB Length = 393 Score = 33.2 bits (74), Expect = 0.24, Method: Composition-based stats. Identities = 28/187 (14%), Positives = 59/187 (31%), Gaps = 29/187 (15%) Query: 58 NLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAEN 117 L G + PQ + + + + P + ++ + N Sbjct: 20 KLLMGPGPSNAPQRVLDAMSRPILGHL---------HPETLK-IMDDIKEGVRYLFQTNN 69 Query: 118 V---TVTTGANEGILSCLMGLLNAGDEVIVFEPFF--DQYIPNIELCGGKVVYVPINPPK 172 + ++ + G+ + L LL GD +++ D+ G V V + Sbjct: 70 IATFCLSASGHGGMEATLCNLLEDGDVILIGHTGHWGDRSADMATRYGADVRVVKSKVGQ 129 Query: 173 ELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNV 232 L R + + K + + + G + L +G +C +HN Sbjct: 130 SLSLDEIR-----------DALLIHKPSVLFLTQGDSSTGV---LQGLEGVGALCHQHNC 175 Query: 233 VIISDEV 239 ++I D V Sbjct: 176 LLIVDTV 182 >1OAT-A nrPDB Length = 439 Score = 32.9 bits (73), Expect = 0.27, Method: Composition-based stats. Identities = 15/65 (23%), Positives = 26/65 (40%), Gaps = 2/65 (3%) Query: 187 DFEQFEKAI-TSKTKAVIINTPHNPIGKVF-TREELTTLGNICVKHNVVIISDEVYEHLY 244 D E+A+ A ++ G V L + +C +H V+ I+DE+ L Sbjct: 211 DLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLA 270 Query: 245 FTDSF 249 T + Sbjct: 271 RTGRW 275 >5KR6-A nrPDB Length = 479 Score = 32.5 bits (72), Expect = 0.35, Method: Composition-based stats. Identities = 24/141 (17%), Positives = 45/141 (31%), Gaps = 10/141 (7%) Query: 147 PFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTID-FEQFEKAI---TSKTKAV 202 P F + + + P E++ ++ EK I T A Sbjct: 187 PAFHNHFDLPL----EPIRHTTCPHYYRAPAGMSEAEFSRHCADELEKMILAEGPDTVAA 242 Query: 203 IINTPHNPIGKVFTREE--LTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIG 260 I P G + E + + K+++++I+DEV T S + Sbjct: 243 FIGEPVMGTGGIVPPPEGYWEAIQAVLNKYDILLIADEVVCGFGRTGSMFGSHHYGMKPD 302 Query: 261 QLTLTVGSAGKSFAATGWRIG 281 +T+ G +G +G Sbjct: 303 LITVAKGLTSAYAPLSGVIVG 323 >5EG1-A nrPDB Length = 580 Score = 32.5 bits (72), Expect = 0.36, Method: Composition-based stats. Identities = 29/216 (13%), Positives = 74/216 (34%), Gaps = 26/216 (12%) Query: 57 INLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPT----RGRPSLINSLIKLYSPIYNTE 112 +NL S+S +LD+ YS T G+ +L+ + Y + + Sbjct: 343 LNLSIRELSFSYSDDKKILNSVSLDLFTGKMYSLTGPSGSGKSTLVKIISGYYKNYFG-D 401 Query: 113 LKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPK 172 + ++++ ++E + + L D + + F+ + N + ++ V Sbjct: 402 IYLNDISLRNISDEDLNDAIYYLTQD-DYIFMDTLRFNLRLANYDASENEIFKVLKLANL 460 Query: 173 ELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNV 232 + + +IN +N G +++ +L + ++ Sbjct: 461 SVVNNEPVSLDTH-----------------LINRGNNYSG---GQKQRISLARLFLRKPA 500 Query: 233 VIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGS 268 +II DE L + + ++++ + S Sbjct: 501 IIIIDEATSALDYINESEILSSIRTHFPDALIINIS 536 >2Z67-A nrPDB Length = 456 Score = 32.5 bits (72), Expect = 0.36, Method: Composition-based stats. Identities = 47/282 (16%), Positives = 98/282 (34%), Gaps = 43/282 (15%) Query: 96 SLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNA-GDEVIVFEPFFDQYIP 154 +L N +++ + + A ++TG + I CL G V+++ + + Sbjct: 133 ALTNKILESFFKQLGLNVHAIATPISTGMS--ISLCLSAARKKYGSNVVIYP--YASHKS 188 Query: 155 NIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKA---------VIIN 205 I+ + L + G+ + E E AI + + + Sbjct: 189 PIKAVSF------VGMNMRLVETVLDGDRVYVPVEDIENAIKKEIELGNRPCVLSTLTFF 242 Query: 206 TPHNPIGKVFTREELTTLGNICVKHNVVIISDEVY--EHLYFTDSFTRIATLSPEIGQLT 263 P N +++ + IC +++ I + Y ++ Y+ + + + Sbjct: 243 PPRN-------SDDIVEIAKICENYDIPHIINGAYAIQNNYYLEKLKKAFKYRVDA---- 291 Query: 264 LTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKI 323 V S+ K+ G V S +AE + + + AS +P N++ L + Sbjct: 292 -VVSSSDKNLLTP-IGGGLVYSTDAEFIKEISL--SYPGRASATP----VVNTLVSLLSM 343 Query: 324 GYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFS 365 G K E + K + DEL + G F+ V+ Sbjct: 344 GS--KNYLELVKNQKNSKKLLDELLNDLSKKTGGKFLDVESP 383 >3DOR-A nrPDB Length = 583 Score = 32.1 bits (71), Expect = 0.47, Method: Composition-based stats. Identities = 24/103 (23%), Positives = 46/103 (44%), Gaps = 15/103 (14%) Query: 149 FDQYIPNIELCGGK-----VVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVI 203 F YI ++ GK + +P ++++ + G +F + + +S T+A+I Sbjct: 276 FRAYISSVTDGDGKSHKVGFLRIPTYSWQDMEDFDPSGPPPWEEFAKIIQVFSSNTEALI 335 Query: 204 INTPHNPIGKVFTREELTTLGNICV-------KHNVVIISDEV 239 I+ +NP G V L L ++ KH +++ DEV Sbjct: 336 IDQTNNPGGSVL---YLYALLSMLTDRPLELPKHRMILTQDEV 375 >6ERK-A nrPDB Length = 451 Score = 32.1 bits (71), Expect = 0.49, Method: Composition-based stats. Identities = 16/71 (22%), Positives = 34/71 (47%), Gaps = 14/71 (19%) Query: 215 FTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFT--RIATLSPEIGQLTLTVGSAGKS 272 ++ + L L +C +++V++I+DE+ + A +SP+ + + GK Sbjct: 245 YSPQYLQLLRKLCDEYDVLLIADEIATGFGRSGKLFACEHAAISPD-------IMTIGK- 296 Query: 273 FAATGWRIGWV 283 A TG G++ Sbjct: 297 -ALTG---GYM 303 >5FXF-A nrPDB Length = 526 Score = 31.7 bits (70), Expect = 0.66, Method: Composition-based stats. Identities = 12/35 (34%), Positives = 15/35 (42%) Query: 65 SYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLIN 99 P AI+ +K LD+ N Y G P LI Sbjct: 297 DGPMPAEAIERMKKDLDLGFWNFYGTLYGPPPLIE 331 >2JIS-A nrPDB Length = 515 Score = 31.7 bits (70), Expect = 0.68, Method: Composition-based stats. Identities = 8/67 (11%), Positives = 24/67 (35%), Gaps = 3/67 (4%) Query: 182 EEWTIDFEQFEKAIT---SKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDE 238 E + E E+ I ++ + + + + + L + ++C +H + + D Sbjct: 237 ERGKMVPEDLERQIGMAEAEGAVPFLVSATSGTTVLGAFDPLEAIADVCQRHGLWLHVDA 296 Query: 239 VYEHLYF 245 + Sbjct: 297 AWGGSVL 303 >5XX1-A nrPDB Length = 756 Score = 31.7 bits (70), Expect = 0.73, Method: Composition-based stats. Identities = 32/248 (12%), Positives = 66/248 (26%), Gaps = 25/248 (10%) Query: 120 VTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVY-VPINPPKELDQRN 178 V G + + + + D V++ + L G K VY VP + Sbjct: 227 VVVGTSGSNRTIMQACMTDNDVVVLDRNCHKSIEQGLILTGAKPVYMVPSRNRYGIIGPI 286 Query: 179 TRGEEWTIDFEQ------FEKAITSKTKAVIINTPHNPI--GKVFTREELTTLGNICVKH 230 E ++ K + + + T N G + +E L K Sbjct: 287 YPQEMQPETLQKKISASPLTKTKAGQKPSYSVVT--NCTYDGVCYNAKEAQDLLA---KT 341 Query: 231 NVVIISDEVYEHL-----YFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGW------R 279 + I DE + + D + G S K A R Sbjct: 342 SDRIHFDEAWYGYARFNPIYCDHYAMRGEPGDHNGPTVFATHSTHKLLNALSQASYIHVR 401 Query: 280 IGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKI 339 G + T + + + ++ + +++ E ++ + Sbjct: 402 EGRGAVNFSRFNQAYMMHATTSPLYAICASNDVAVSMMDGNSGLSLTQEVIDEAVDFRQA 461 Query: 340 FTSIFDEL 347 ++ E Sbjct: 462 MARLYKEF 469 >1QZ9-A nrPDB Length = 416 Score = 31.7 bits (70), Expect = 0.73, Method: Composition-based stats. Identities = 21/149 (14%), Positives = 41/149 (27%), Gaps = 23/149 (15%) Query: 101 LIKLYSPIYNTELKAEN--VTVTTGANEGILSCL------MGLLNAGDEVIVFEPFFDQY 152 L + T + A + V VT + + L + VIV E Sbjct: 72 LSERLGNRLATLIGARDGEVVVTDTTSINLFKVLSAALRVQATRSPERRVIVTE------ 125 Query: 153 IPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIG 212 + I + E+ +AI T V++ + G Sbjct: 126 ------TSNFPTDLYIAEGLADMLQQGYTLRLVDSPEELPQAIDQDTAVVMLTHVNYKTG 179 Query: 213 KVFTREELTTLGNICVKHNVVIISDEVYE 241 + ++ L + + + I D + Sbjct: 180 YM---HDMQALTALSHECGALAIWDLAHS 205 >3N5M-A nrPDB Length = 452 Score = 31.3 bits (69), Expect = 0.78, Method: Composition-based stats. Identities = 20/134 (14%), Positives = 41/134 (30%), Gaps = 10/134 (7%) Query: 216 TREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAA 275 ++ + + C KH ++ISDEV T + +T+ G Sbjct: 234 PQDYMKAVHETCQKHGALLISDEVICGFGRTGKAFGFMNYDVKPDIITMAKGITSAYLPL 293 Query: 276 TGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQ---EACANSINDALKIGYFEKMRQE 332 + ++ E+ F + ACA ++ + L+I E + + Sbjct: 294 S------ATAVKREIYEAFKGKGEYEFFRHINTFGGNPAACALALKN-LEIIENENLIER 346 Query: 333 YINKFKIFTSIFDE 346 + E Sbjct: 347 SAQMGSLLLEQLKE 360 >1S09-A nrPDB Length = 429 Score = 31.3 bits (69), Expect = 0.78, Method: Composition-based stats. Identities = 10/48 (20%), Positives = 23/48 (47%), Gaps = 2/48 (4%) Query: 213 KVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFT--RIATLSPE 258 +++ E L + IC + +++I+DE+ T A ++P+ Sbjct: 221 RMYHPEWLKRIRKICDREGILLIADEIATGFGRTGKLFACEHAEIAPD 268 >4GRX-A nrPDB Length = 465 Score = 31.3 bits (69), Expect = 0.80, Method: Composition-based stats. Identities = 45/364 (12%), Positives = 99/364 (27%), Gaps = 51/364 (14%) Query: 112 ELKAENVTVTTGANEGILSCLMGL----LNAGD----EVIVFEPFFDQYIPNIELCGGKV 163 V T +E + + L G +++ + GK Sbjct: 117 PFDNGRVFYTNSGSEANDTMVKMLWFLHAAEGKPQKRKILTRWNAYHGVTAVSASMTGKP 176 Query: 164 ------------VYVPINPPKELDQRNTRGEEWTIDFE-QFEKAITSKTKAVIINTPHNP 210 +++ + ++ + E IT + I P Sbjct: 177 YNSVFGLPLPGFIHLTCPHYWRYGEEGETEAQFVARLARELEDTITREGADTIAGFFAEP 236 Query: 211 I---GKVFTRE--ELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLT 265 + G V + I K+++ +ISDEV T + L+ + + Sbjct: 237 VMGAGGVIPPAKGYFQAILPILRKYDIPMISDEVICGFGRTGN--TWGCLTYDFMPDAII 294 Query: 266 VGSAGKSFAATGWRIGWVLSLN--AELLSYAAKAHTRICFASPSPLQEACANSINDALKI 323 + K+ A + +G V+ A+ + A +A + A+ + Sbjct: 295 ---SSKNLTAGFFPMGAVILGPDLAKRVEAAVEAIEEFPHGFTASGHPVGCAIALKAIDV 351 Query: 324 GYFEKMRQEYINKFKIFTSIFDELGLPYTAPE--GTYFVLVDFSKVKIPEDYPYPEEILN 381 E + + F + + E G F+ + P P+ + Sbjct: 352 VMNEGLAENVRRLAPRFEAGLKRIADRPNIGEYRGIGFMWALEAVKDKPTKTPFDANLSV 411 Query: 382 KGKDFRISHWLINELGVVAIP-PTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLL 440 + L G++ P + +A ++ E+L+ Sbjct: 412 SERIANTCTDL----GLICRPLGQSIVLCPP-----------FILTEAQMDEMFEKLEKA 456 Query: 441 KDYL 444 D + Sbjct: 457 LDKV 460 >5KQT-A nrPDB Length = 479 Score = 31.3 bits (69), Expect = 0.81, Method: Composition-based stats. Identities = 28/184 (15%), Positives = 54/184 (29%), Gaps = 29/184 (15%) Query: 187 DFEQFEKAITSKTKAVIINTPHNPIGKVF--TREELTTLGNICVKHNVVIISDEVYEHL- 243 + E A T A I P G + + + + K++V++I+DEV Sbjct: 227 ELENLILAEGPDTVAAFIGEPVMGTGGIIVPPKGYWEAIQAVLAKYDVLLIADEVVCAFG 286 Query: 244 ----------------------YFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIG 281 T ++ ++ + ++ + SA A G G Sbjct: 287 RLGDKMGSQRHAMRPDLITTAKGLTSAYAPLSAVIVG-EKVWDVIDSASTREGAMGH--G 343 Query: 282 WVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFT 341 W S + + + AA A+ I A + FE + Sbjct: 344 WTYSGHP-ICAAAALANLDILERENITANAADVGGYLNQQLRQAFEGHPLVGEVRGDGML 402 Query: 342 SIFD 345 + + Sbjct: 403 AALE 406 >2ZUK-A nrPDB Length = 439 Score = 31.3 bits (69), Expect = 0.87, Method: Composition-based stats. Identities = 16/86 (18%), Positives = 31/86 (36%), Gaps = 2/86 (2%) Query: 155 NIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKV 214 + G ++ P +P + T T+ E+ A I + G + Sbjct: 159 AAKADGLILLPYP-DPYRPYRNDPTGDAILTLLTEKLAAVPAGSIGAAFIEPIQSDGGLI 217 Query: 215 FTRE-ELTTLGNICVKHNVVIISDEV 239 + L +IC H ++++ DEV Sbjct: 218 VPPDGFLRKFADICRAHGILVVCDEV 243 >2YWH-A nrPDB Length = 600 Score = 31.3 bits (69), Expect = 0.94, Method: Composition-based stats. Identities = 38/277 (13%), Positives = 79/277 (28%), Gaps = 48/277 (17%) Query: 39 NEAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPM-----VNQYSPTRG 93 + + + K Q E++ L P + + A++ + I VN+ P +G Sbjct: 135 IDLPSADVDRVKKQIEEVLGL-------DPEEAILASAKEGIGIEEILEAIVNRIPPPKG 187 Query: 94 RP--SLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQ 151 P L + Y Y + + G + GD++++ Sbjct: 188 DPQKPLKALIFDSYYDPYRGAV-------------AFVRIFDGEVKPGDKIML------- 227 Query: 152 YIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPI 211 +V V PK + + + I NP Sbjct: 228 ---MSTGKEYEVTEVGAQTPKMTKFDKLSAGDVGYIAASIKDVRDIRI-GDTITHAKNPT 283 Query: 212 GKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGK 271 + + + D YE L D+ + A I + Sbjct: 284 KEPVPGFQPAKPMVYA---GIYPAEDTTYEEL--RDALEKYA-----INDAAIVYEPESS 333 Query: 272 SFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSP 308 G+R+G++ L+ E++ + + + +P Sbjct: 334 PALGMGFRVGFLGLLHMEIVQERLEREYGVKIITTAP 370 >6IO1-A nrPDB Length = 451 Score = 30.9 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 31/219 (14%), Positives = 65/219 (29%), Gaps = 8/219 (3%) Query: 170 PPKELDQRNTRGEEWTIDF-EQFEKAI---TSKTKAVIINTP-HNPIGKVFTRE-ELTTL 223 P K EE+ ++ E+ I S+T A I P G V + + Sbjct: 187 PYKYRFGEGLTDEEFVARLVQELEETIEREGSETIAAFIGEPVQGAGGVVVPPDGYWPAI 246 Query: 224 GNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWV 283 + K+ +++I DEV T + + + +T G G +G Sbjct: 247 AAVLRKYGILLILDEVITGFGRTGTLFGMQQYGVQPDIVTFAKGITSGYVPLGG--VGVS 304 Query: 284 LSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSI 343 + L S ++ +++ L +E + + Sbjct: 305 DEIAETLASADRVFMHGFTYSGHPVACAVALRNLDILLAERLWENAAASGAYLLQELKRL 364 Query: 344 FDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNK 382 + + +G ++ E +P ++ K Sbjct: 365 EERPYVGEVRGKGLMLLVEVVRDKASKEKFPPEFKLGPK 403 >5O5C-A nrPDB Length = 519 Score = 30.9 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 22/197 (11%), Positives = 58/197 (29%), Gaps = 31/197 (15%) Query: 91 TRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLN-------AGDEVI 143 + G + +I A+ + T+G + L ++ + G + Sbjct: 138 SAGGTLIEQKVIDWTLSRIGLPAGADGI-FTSGGTQSNLMAMLLARDSWCAAHHPG--HL 194 Query: 144 VFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRG-------EEWTIDFEQFEKAIT 196 + + K+ + I + E + +D + ++ + Sbjct: 195 IKHRGLPHDAAKWRVFTSKLSHFSIQKSMAILGLGYDAVIPVDYDERYRMDVDCLKQEVQ 254 Query: 197 SKTKAVIINTPHNPIGKVF--------TREELTTLGNICVKHNVVIISDEVYE-HLYFTD 247 + +I P+ V + + L + +C H + + D Y L ++ Sbjct: 255 RCLQQGLI-----PVAVVATSGTTDFGSIDPLGAISELCKHHGMWMHVDAAYGCGLLVSE 309 Query: 248 SFTRIATLSPEIGQLTL 264 S + +T+ Sbjct: 310 SHRPRLAGIEKADSVTV 326 >6GIO-D nrPDB Length = 439 Score = 30.9 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 9/27 (33%), Positives = 14/27 (51%) Query: 213 KVFTREELTTLGNICVKHNVVIISDEV 239 V L L + C KH ++++ DEV Sbjct: 214 VVPPPAFLEALQDRCRKHGILVVVDEV 240 >6JRL-A nrPDB Length = 510 Score = 30.5 bits (67), Expect = 1.3, Method: Composition-based stats. Identities = 13/73 (17%), Positives = 28/73 (38%), Gaps = 11/73 (15%) Query: 181 GEEWTIDFEQFEKAITS-----KTKAVIINTPHNPIGKVFTR--EELTTLGNICVKHNVV 233 GE++ + + AI + + + T +G T +++ +L +C + V Sbjct: 212 GEDFVLRGDTLRGAIEEDVAAGRIPVICVAT----LGTTGTCAYDDIESLSAVCEEFKVW 267 Query: 234 IISDEVYEHLYFT 246 + D Y F Sbjct: 268 LHVDAAYAGGAFA 280 >5GHG-A nrPDB Length = 456 Score = 30.5 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 34/231 (14%), Positives = 70/231 (30%), Gaps = 15/231 (6%) Query: 175 DQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVF--TREELTTLGNICVKHNV 232 + + EQ A T A I P G V + + + ++++ Sbjct: 194 ESEEQFATRLADELEQLIIAEGPHTIAAFIGEPVMGAGGVVVPPKTYWEKVQAVLKRYDI 253 Query: 233 VIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLS 292 ++I+DEV T + T + L + K +++ I L Sbjct: 254 LLIADEVICGFGRTGNLFGSQTFDMKPDILVM-----SKQLSSSYLPISAFLINERVYAP 308 Query: 293 YAAKAH--TRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLP 350 A ++H + + A + L I + ++ EL Sbjct: 309 IAEESHKIGTLGTGFTASGHPVAAAVALENLAIIEERDLVANARDRGTYMQKRLRELQDH 368 Query: 351 YTAPE--GTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVV 399 E G + + V++ D + G ++ ++ E GV+ Sbjct: 369 PLVGEVRGVGLI----AGVELVTDKQAKTGLEPTGALGAKANAVLQERGVI 415 >2OKJ-A nrPDB Length = 504 Score = 30.5 bits (67), Expect = 1.5, Method: Composition-based stats. Identities = 12/64 (18%), Positives = 20/64 (31%), Gaps = 3/64 (4%) Query: 182 EEWTIDFEQFEKAITS-KTKAV--IINTPHNPIGKVFTREELTTLGNICVKHNVVIISDE 238 E I FE I K K + + + +IC K+N+ + D Sbjct: 223 ERGKIIPADFEAKILEAKQKGYVPFYVNATAGTTVYGAFDPIQEIADICEKYNLWLHVDA 282 Query: 239 VYEH 242 + Sbjct: 283 AWGG 286 >1OHW-A nrPDB Length = 472 Score = 30.5 bits (67), Expect = 1.5, Method: Composition-based stats. Identities = 14/62 (22%), Positives = 20/62 (32%), Gaps = 4/62 (6%) Query: 216 TREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAA 275 + + L +I KH + DEV T F A + V + K Sbjct: 277 SDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKF--WAHEHWGLDDPA-DVMTFSKKM-M 332 Query: 276 TG 277 TG Sbjct: 333 TG 334 >4BQ0-A nrPDB Length = 448 Score = 30.2 bits (66), Expect = 1.9, Method: Composition-based stats. Identities = 12/57 (21%), Positives = 24/57 (42%), Gaps = 9/57 (15%) Query: 220 LTTLGNICVKHNVVIISDEV---------YEHLYFTDSFTRIATLSPEIGQLTLTVG 267 L L IC +HN+++I DEV Y + + ++ ++ + +G Sbjct: 242 LQRLREICDQHNILLIFDEVITAFGRLGTYSGAEYFGVTPDLMNVAKQVTNGAVPMG 298 >3DR3-A nrPDB Length = 337 Score = 30.2 bits (66), Expect = 1.9, Method: Composition-based stats. Identities = 11/53 (20%), Positives = 17/53 (32%), Gaps = 1/53 (1%) Query: 87 QYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANE-GILSCLMGLLNA 138 Y T P L+ + +LK N+ G L L++A Sbjct: 120 YYGFTHQYPELLEQAAYGLAEWCGNKLKEANLIAVPGCYPTAAQLALKPLIDA 172 >4ROS-A nrPDB Length = 320 Score = 30.2 bits (66), Expect = 2.0, Method: Composition-based stats. Identities = 21/110 (19%), Positives = 31/110 (28%), Gaps = 20/110 (18%) Query: 345 DELGLPYTAPEGTYFVLV--DFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIP 402 D + T P V FS + + + R H+L E GV Sbjct: 113 DAFVICITNPLDAM-VWALQKFSGLPTNKVVGMAGVL----DSARFRHFLAEEFGVSVED 167 Query: 403 PTEFYIKEHEKAAENLLRFAVC-------------KDDAYLENAVERLKL 439 T F + H L R++ L+ VER + Sbjct: 168 VTAFVLGGHGDDMVPLTRYSTVAGVPLTDLVKLGWTTQEKLDAMVERTRK 217 >4E1O-A nrPDB Length = 481 Score = 30.2 bits (66), Expect = 2.1, Method: Composition-based stats. Identities = 14/85 (16%), Positives = 28/85 (32%), Gaps = 9/85 (10%) Query: 161 GKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREEL 220 K+ ++P++ L + + E+ V + G + L Sbjct: 210 VKMKFLPVDDNFSLRGEALQ--------KAIEEDKQRGLVPVFVCATLGTTGVC-AFDCL 260 Query: 221 TTLGNICVKHNVVIISDEVYEHLYF 245 + LG IC + + + D Y F Sbjct: 261 SELGPICAREGLWLHIDAAYAGTAF 285 >6EEI-A nrPDB Length = 490 Score = 29.8 bits (65), Expect = 2.3, Method: Composition-based stats. Identities = 12/78 (15%), Positives = 25/78 (32%), Gaps = 3/78 (3%) Query: 168 INPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIIN---TPHNPIGKVFTREELTTLG 224 I+P + + E ++A++ +A +I + + L LG Sbjct: 205 IHPENCRVLTTDSSTNYALRPESLQEAVSRDLEAGLIPFFLCANVGTTSSTAVDPLAALG 264 Query: 225 NICVKHNVVIISDEVYEH 242 I + + D Y Sbjct: 265 KIANSNGIWFHVDAAYAG 282 >1VRD-A nrPDB Length = 494 Score = 29.8 bits (65), Expect = 2.5, Method: Composition-based stats. Identities = 40/286 (13%), Positives = 84/286 (29%), Gaps = 46/286 (16%) Query: 68 PPQFAIKEAQKALDIPMVNQYSPTRGRPSLI-----NSLIKLYSPIYNTELKAENVTV-- 120 PP ++++A++ L + + L+ ++ + + + V Sbjct: 171 PPDISLEKAKEILHQHRIEKLPLVSKDNKLVGLITIKDIMSVIEHPNAARDEKGRLLVGA 230 Query: 121 TTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTR 180 G + + + L+ AG +VIV + IE P P + Sbjct: 231 AVGTSPETMERVEKLVKAGVDVIVIDTAHGHSRRVIETLEMIKADYPDLPVVAGN----- 285 Query: 181 GEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTR----------EELTTLGNICVKH 230 E E I + AV + P TR + + K+ Sbjct: 286 ----VATPEGTEALIKAGADAVKVGVG--PGSICTTRVVAGVGVPQLTAVMECSEVARKY 339 Query: 231 NVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGS-AGKSFAATGWRIGWVLSLNAE 289 +V II+D + ++ + E ++ VGS + A G Sbjct: 340 DVPIIAD---GGIRYSGDIVKALAAGAE----SVMVGSIFAGTEEAPG----------ET 382 Query: 290 LLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYIN 335 +L K S ++ A+ + + + + + Sbjct: 383 ILYQGRKYKAYRGMGSLGAMRSGSADRYGQEGENKFVPEGIEGMVP 428 >5VNX-A nrPDB Length = 393 Score = 29.4 bits (64), Expect = 3.0, Method: Composition-based stats. Identities = 24/180 (13%), Positives = 46/180 (25%), Gaps = 29/180 (16%) Query: 94 RPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYI 153 L + L + + +TG L+ + L + I Sbjct: 86 HAKLEDELAGFAGGFSDA---PRALYFSTG-YMANLAAVTALAGKDATIFSDALNHASLI 141 Query: 154 PNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGK 213 L V P T +A TS+TK ++ Sbjct: 142 DGTRLSRATVQVYPHAD--------------TATLGALLEACTSQTKLIV-------TDT 180 Query: 214 VFTRE----ELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSA 269 VF+ + L L + +H ++ D+ + + + VG+ Sbjct: 181 VFSMDGDIAPLAELLALAERHGAWLVVDDAHGFGVLGPQGRGALAAAALRSPHLVYVGTL 240 >2E8Y-A nrPDB Length = 718 Score = 29.0 bits (63), Expect = 3.9, Method: Composition-based stats. Identities = 13/66 (19%), Positives = 23/66 (34%), Gaps = 4/66 (6%) Query: 205 NTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTL 264 + PH+P + EL + N +H + +I D V+ H + + P Sbjct: 306 SNPHDP---QTRKTELKQMINTLHQHGLRVILDVVFNH-VYKRENSPFEKTVPGYFFRHD 361 Query: 265 TVGSAG 270 G Sbjct: 362 ECGKPS 367 >4WYG-A nrPDB Length = 457 Score = 29.0 bits (63), Expect = 4.1, Method: Composition-based stats. Identities = 8/24 (33%), Positives = 14/24 (58%) Query: 216 TREELTTLGNICVKHNVVIISDEV 239 L L +IC ++ V++I DE+ Sbjct: 253 DPRYLHDLRDICRRYEVLLIFDEI 276 >1WA5-C nrPDB Length = 960 Score = 29.0 bits (63), Expect = 4.3, Method: Composition-based stats. Identities = 8/36 (22%), Positives = 17/36 (47%) Query: 202 VIINTPHNPIGKVFTREELTTLGNICVKHNVVIISD 237 ++ P NP +T E + + N + N+ ++ D Sbjct: 605 IMAKNPSNPRFTHYTFESIGAILNYTQRQNLPLLVD 640 >4W8Y-A nrPDB Length = 888 Score = 29.0 bits (63), Expect = 4.6, Method: Composition-based stats. Identities = 8/55 (14%), Positives = 22/55 (40%) Query: 77 QKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSC 131 + ++IP YS + ++ +L + +K E + + G ++ + Sbjct: 642 RDYVEIPEAKYYSTPQVHVAISQALANFSIREVRSVVKDEGLLIYAGGDDVLAIL 696 >2BHU-A nrPDB Length = 602 Score = 28.6 bits (62), Expect = 5.2, Method: Composition-based stats. Identities = 11/69 (15%), Positives = 23/69 (33%), Gaps = 10/69 (14%) Query: 207 PHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTV 266 P+ P G+ E+L L + + + + D VY H + ++ S Sbjct: 185 PYAPYGR---PEDLMALVDAAHRLGLGVFLDVVYNHFGPSGNYLSSYAPS-------YFT 234 Query: 267 GSAGKSFAA 275 ++ Sbjct: 235 DRFSSAWGM 243 >5EAV-A nrPDB Length = 441 Score = 28.6 bits (62), Expect = 5.8, Method: Composition-based stats. Identities = 40/245 (16%), Positives = 78/245 (31%), Gaps = 12/245 (4%) Query: 187 DFEQFEKAI-TSKTKAVIINTPHNPIGKVFTRE-ELTTLGNICVKHNVVIISDEVYEHLY 244 D E+A+ A + G + L +C NV++I DE+ L Sbjct: 205 DVGALEEALKDPNVAAFFVEPIQGEGGVNVPKPGYLKRAHELCRSKNVLLIVDEIQTGLC 264 Query: 245 FTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFA 304 T +A E+ L +G KS +A I + A+++ F Sbjct: 265 RTGRL--LAADHDEVHPDILLLG---KSLSAGVVPIS-AVMGRADVMDVLKPGTHGSTFG 318 Query: 305 SPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDF 364 ++ LK + +F+ +P+ Sbjct: 319 GNPLACAVAVEAL-TVLKDEKLADRAERLGAQFRDCLRRELYGKVPWIKEIRG---RGLL 374 Query: 365 SKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVC 424 + V++ D P +++ K K+ I + IPP +EH A +++ + Sbjct: 375 NAVEVDSDAIDPNDVVMKLKENGILSKPTRGRVMRFIPPLVITDEEHRDATTRIIKSFLA 434 Query: 425 KDDAY 429 ++ Sbjct: 435 VEEER 439 >3TL2-A nrPDB Length = 315 Score = 28.2 bits (61), Expect = 6.9, Method: Composition-based stats. Identities = 18/111 (16%), Positives = 34/111 (30%), Gaps = 11/111 (9%) Query: 337 FKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINEL 396 I + + + T P F + P++ + + R ++ EL Sbjct: 112 RDIAKHSPNAIIVVLTNPVDAM-TYSVFKEAGFPKERVIGQSGVL--DTARFRTFIAQEL 168 Query: 397 GVVAIPPTEFYIKEHEKAAENLLRFAVCK--------DDAYLENAVERLKL 439 + T F + H L+R++ LE VER + Sbjct: 169 NLSVKDITGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERLEAIVERTRK 219 >2C8J-A nrPDB Length = 311 Score = 28.2 bits (61), Expect = 7.9, Method: Composition-based stats. Identities = 15/76 (19%), Positives = 31/76 (40%), Gaps = 1/76 (1%) Query: 51 NQGRELINLGQGFFS-YSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIY 109 +G E+ N G+ S + P I + L + +Y T + + + + +Y Sbjct: 207 ARGAEVANYAVGWQSAGNTPDPWIGPDVQDLTRELNEKYGYTSFVYAPVGFVAEHLEVLY 266 Query: 110 NTELKAENVTVTTGAN 125 + + + + VT GA Sbjct: 267 DNDFECKVVTDEIGAK 282 >6EEW-A nrPDB Length = 500 Score = 27.9 bits (60), Expect = 8.5, Method: Composition-based stats. Identities = 12/99 (12%), Positives = 27/99 (27%), Gaps = 12/99 (12%) Query: 148 FFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKA----VI 203 + +L G + + P T ++ I + K + A + Sbjct: 202 THTMFPKTCKLAGIYPNNIRLIP-------TTVETDFGISPQVLRKMVEDDVAAGYVPLF 254 Query: 204 INTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEH 242 + + + +L I + + I D Y Sbjct: 255 LCATLG-TTSTTATDPVDSLSEIANEFGIWIHVDAAYAG 292 >6GPA-A nrPDB Length = 314 Score = 27.9 bits (60), Expect = 9.3, Method: Composition-based stats. Identities = 20/127 (15%), Positives = 39/127 (30%), Gaps = 8/127 (6%) Query: 30 TAKDVWSLTNEAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYS 89 KD W+ N+ KA + R +I+ P + EA K L + Sbjct: 58 NPKDGWNNMNDVIVKAKRAERLGLRTMIDFHFSDTWADPGHQEMPEAWKELSFDDLKI-- 115 Query: 90 PTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFF 149 +L + + + + + E V V G++ + + N + + Sbjct: 116 ------ALSEHVKSVLTALKAVGVTPEWVQVGNETTPGMMLPVGSVDNPEQLTALNNAGY 169 Query: 150 DQYIPNI 156 D Sbjct: 170 DAVKAIC 176 >6GP5-A nrPDB Length = 352 Score = 27.9 bits (60), Expect = 9.3, Method: Composition-based stats. Identities = 20/127 (15%), Positives = 39/127 (30%), Gaps = 8/127 (6%) Query: 30 TAKDVWSLTNEAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYS 89 KD W+ N+ KA + R +I+ P + EA K L + Sbjct: 94 NPKDGWNNMNDVIVKAKRAERLGLRTMIDFHFSDTWADPGHQEMPEAWKELSFDDLKI-- 151 Query: 90 PTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFF 149 +L + + + + + E V V G++ + + N + + Sbjct: 152 ------ALSEHVKSVLTALKAVGVTPEWVQVGNETTPGMMLPVGSVDNPEQLTALNNAGY 205 Query: 150 DQYIPNI 156 D Sbjct: 206 DAVKAIC 212 >4UHN-A nrPDB Length = 468 Score = 27.9 bits (60), Expect = 9.7, Method: Composition-based stats. Identities = 9/26 (34%), Positives = 15/26 (57%) Query: 214 VFTREELTTLGNICVKHNVVIISDEV 239 V + L L IC +++++I DEV Sbjct: 256 VPPKGYLQRLREICDANDILLIFDEV 281 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.122 0.306 Lambda K H 0.267 0.0373 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 14,633,165 Number of Sequences: 36641 Number of extensions: 549414 Number of successful extensions: 2879 Number of sequences better than 10.0: 298 Number of HSP's better than 10.0 without gapping: 276 Number of HSP's successfully gapped in prelim test: 132 Number of HSP's that attempted gapping in prelim test: 2006 Number of HSP's gapped (non-prelim): 434 length of query: 444 length of database: 10,336,785 effective HSP length: 100 effective length of query: 344 effective length of database: 6,672,685 effective search space: 2295403640 effective search space used: 2295403640 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.5 bits) S2: 60 (27.9 bits)