BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P46680 (615 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1PI6-A nrPDB 1259 0.0 1NR0-A nrPDB 252 3e-67 5NNZ-B nrPDB 66 5e-11 2H9P-A nrPDB 64 3e-10 5M25-A nrPDB 63 4e-10 6N9G-C nrPDB 54 2e-07 6Q8F-A nrPDB 51 1e-06 5FL8-q nrPDB 51 2e-06 6MZM-G nrPDB 50 2e-06 6F3T-A nrPDB 50 2e-06 6QX9-4B nrPDB 50 3e-06 5FVM-C nrPDB 48 1e-05 6ID0-T nrPDB 47 3e-05 3DM0-A nrPDB 46 6e-05 6QX9-5O nrPDB 45 7e-05 5WYJ-BC nrPDB 45 8e-05 6HHQ-h nrPDB 45 9e-05 5Y88-O nrPDB 44 2e-04 6GMH-W nrPDB 44 3e-04 5Z56-q nrPDB 43 3e-04 3JB9-S nrPDB 43 5e-04 6ELZ-p nrPDB 43 5e-04 5K1B-B nrPDB 43 5e-04 4LG8-A nrPDB 42 6e-04 4V6W-Ag nrPDB 41 0.002 3JB9-L nrPDB 40 0.002 2YNP-A nrPDB 40 0.002 4YCZ-A nrPDB 40 0.003 3MKQ-A nrPDB 40 0.004 5L9T-R nrPDB 39 0.005 4V8M-A7 nrPDB 39 0.005 5MZH-A nrPDB 39 0.006 4PSX-B nrPDB 39 0.007 1VYH-C nrPDB 39 0.008 6BX3-A nrPDB 38 0.011 6J6H-n nrPDB 38 0.012 5GAN-H nrPDB 38 0.012 5OPT-p nrPDB 38 0.012 6EMK-B nrPDB 38 0.014 5WLC-LO nrPDB 37 0.023 5I2T-A nrPDB 37 0.024 6QDV-o nrPDB 37 0.027 6BX3-B nrPDB 37 0.035 5NZU-C nrPDB 37 0.035 5OQL-L nrPDB 37 0.036 5WYK-BB nrPDB 36 0.039 5YZG-W nrPDB 36 0.050 4U1E-I nrPDB 36 0.062 5UZ7-B nrPDB 35 0.070 4N14-A nrPDB 35 0.079 5WJC-A nrPDB 35 0.080 5WLC-LU nrPDB 35 0.081 4GGA-A nrPDB 35 0.11 5LCW-Q nrPDB 35 0.11 4BZK-B nrPDB 35 0.13 4BH6-A nrPDB 35 0.13 3ODT-A nrPDB 35 0.13 3JRP-A nrPDB 34 0.16 3FM0-A nrPDB 34 0.18 4BTS-AR nrPDB 34 0.18 3JAP-g nrPDB 34 0.19 5G04-R nrPDB 34 0.21 5A31-R nrPDB 34 0.24 5WLC-LN nrPDB 33 0.25 4AEZ-A nrPDB 33 0.29 3JRO-A nrPDB 33 0.30 5YZG-2 nrPDB 33 0.31 6G51-g nrPDB 33 0.36 3JB9-g nrPDB 33 0.47 4L9O-A nrPDB 33 0.48 5XYI-g nrPDB 33 0.50 5A9Q-0 nrPDB 32 0.59 2HES-X nrPDB 32 0.83 3BG0-A nrPDB 32 1.2 5OQL-X nrPDB 31 1.4 6CHG-A nrPDB 31 1.5 4YHC-A nrPDB 31 1.5 5Y1U-A nrPDB 30 2.3 6HQA-B nrPDB 30 2.5 5WBU-D nrPDB 30 2.8 5CXB-B nrPDB 30 3.4 3W15-A nrPDB 30 3.4 5GRS-A nrPDB 30 3.6 4A11-B nrPDB 30 4.0 3SH1-A nrPDB 29 5.1 3JZG-A nrPDB 29 5.2 4A5P-A nrPDB 29 5.3 5N4A-A nrPDB 29 5.7 5CXC-A nrPDB 29 5.8 4XYI-A nrPDB 29 6.2 3C9C-A nrPDB 29 7.7 3OP1-A nrPDB 28 8.8 3I2N-A nrPDB 28 9.6 >1PI6-A nrPDB Length = 615 Score = 1259 bits (3259), Expect = 0.0, Method: Compositional matrix adjust. Identities = 614/615 (99%), Positives = 614/615 (99%) Query: 1 MSSISLKEIIPPQPSTQRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFT 60 MSSISLKEIIPPQPSTQRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFT Sbjct: 1 MSSISLKEIIPPQPSTQRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFT 60 Query: 61 GHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPIS 120 GHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPIS Sbjct: 61 GHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPIS 120 Query: 121 DISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVG 180 DISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVG Sbjct: 121 DISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVG 180 Query: 181 DDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGE 240 DDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGE Sbjct: 181 DDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGE 240 Query: 241 FLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQ 300 FLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQ Sbjct: 241 FLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQ 300 Query: 301 QVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPLISGSYDGRIM 360 QVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPLISGSYDGRIM Sbjct: 301 QVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPLISGSYDGRIM 360 Query: 361 EWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFT 420 EWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFT Sbjct: 361 EWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFT 420 Query: 421 AVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVS 480 AVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVS Sbjct: 421 AVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVS 480 Query: 481 FDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWK 540 FDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAF TSKINAISWK Sbjct: 481 FDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFRTSKINAISWK 540 Query: 541 PAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVS 600 PAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVS Sbjct: 541 PAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVS 600 Query: 601 SGADACIKRWNVVLE 615 SGADACIKRWNVVLE Sbjct: 601 SGADACIKRWNVVLE 615 >1NR0-A nrPDB Length = 611 Score = 252 bits (644), Expect = 3e-67, Method: Compositional matrix adjust. Identities = 203/649 (31%), Positives = 324/649 (49%), Gaps = 77/649 (11%) Query: 1 MSSISLKEIIPPQPSTQRNFTTHLSYDPTTNAIAYPCGKSAF---VRCLDDGDSKVPPVV 57 MS S + P P T R L P + I Y G S + V L D + Sbjct: 1 MSEFSQTALFPSLPRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTE------- 53 Query: 58 QFTGHGSSVVTTVKFSPIKGSQYLC-SGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLA 116 +T H S T K SP S Y C SGD G V +W ++ +K+ V + Sbjct: 54 IYTEH-SHQTTVAKTSP---SGYYCASGDVHGNVRIW------DTTQTTHILKTTIPVFS 103 Query: 117 GPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRS 176 GP+ DISWD E +R+ VGEGR+ FG +D+G S G ++G ++ +N+ K SRP R Sbjct: 104 GPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRI 163 Query: 177 MTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDG 236 ++ DD +V ++GPPFKF ++ H K FV V ++PD G + G D I ++G Sbjct: 164 ISGSDDNTVAIFEGPPFKFKSTFGEHTK---FVHSVRYNPD-GSLFASTGGDGTIVLYNG 219 Query: 237 KSGEFLKYIEDD---QEPVQGGIFALSW-LDSQKFATVGADATIRVWDVTTSKCVQKWTL 292 G EDD G +F L+W D K A+ AD TI++W+V T K V+K Sbjct: 220 VDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLK-VEKTIP 278 Query: 293 DKQQLGNQQVGVVATGNGRIISLSLDGTLNFY--ELGHDEVLKTISGHNKGITALTVNP- 349 ++ +QQ+G++ T ++S+S +G +NF ELG + ++ GHNK ITAL+ + Sbjct: 279 VGTRIEDQQLGIIWTKQA-LVSISANGFINFVNPELGSIDQVRY--GHNKAITALSSSAD 335 Query: 350 ---LISGSYDGRIMEWSSSSMHQD------HSNLIVSLDNSKAQEYSSISWDDTLKV--- 397 L S +G I W S+ + H+ +I + + + ++SWDD LKV Sbjct: 336 GKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPA 395 Query: 398 --NGI-----TKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIK-SVRLNSPG 449 +G+ ++ SQP + + DG AV + I G + + + NS Sbjct: 396 GGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSH--GKLTEVPISYNSSC 453 Query: 450 SAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLR-AKPSYISISPSETYIAAGDV 508 A+S + +VAVG ++ + + V+KLS VS ++KT + A+ + ++ S + ++ A D Sbjct: 454 VALSNDKQFVAVGGQD-SKVHVYKLSGASVS-EVKTIVHPAEITSVAFSNNGAFLVATDQ 511 Query: 509 MGKILLYDLQS--REVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIF 566 K++ Y + + T+ W FHT+K+ +SW P + +ATGSLD ++ Sbjct: 512 SRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSP----------DNVRLATGSLDNSVI 561 Query: 567 IYSVKRPMK---IIKALNAHKDGVNNLLWETPSTLVSSGADACIKRWNV 612 ++++ +P IIK +A VN+++W +T+VS+G D+ IK WNV Sbjct: 562 VWNMNKPSDHPIIIKGAHA-MSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 >5NNZ-B nrPDB Length = 415 Score = 65.9 bits (159), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 70/268 (26%), Positives = 117/268 (43%), Gaps = 28/268 (10%) Query: 218 SGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIR 277 SG IT DR +D SGE L +E + V F + D K AT D T + Sbjct: 103 SGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGD--KIATGSFDKTCK 160 Query: 278 VWDVTTSKCVQKWTLDKQQL----GNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLK 333 +W V T KC + ++ N Q +VATG S+D T +++ + E + Sbjct: 161 LWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATG-------SMDTTAKLWDIQNGEEVY 213 Query: 334 TISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSI 389 T+ GH+ I +L+ N +I+GS+D ++ W + + + N+++ + +S Sbjct: 214 TLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRK--VNILIG--HCAEISSASF 269 Query: 390 SWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSF--TGDIIKSVRLNS 447 +WD +L + G K+ A N A LT DD ++ F TG +I + + Sbjct: 270 NWDCSLILTG----SMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADG 325 Query: 448 PGSAVSLSQNYVAVGLEEGNTIQVFKLS 475 S + L EG+ ++ K+S Sbjct: 326 TARIFSAATRKCIAKL-EGHEGEISKIS 352 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 36/154 (23%), Positives = 64/154 (41%), Gaps = 12/154 (7%) Query: 218 SGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIR 277 SG+ +IT D + +D +G + + + F +W D T D T + Sbjct: 230 SGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASF--NW-DCSLILTGSMDKTCK 286 Query: 278 VWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISL-SLDGTLNFYELGHDEVLKTIS 336 +WD T KCV T ++ + G++I+ S DGT + + + + Sbjct: 287 LWDATNGKCVATLTGHDDEILDSCFDYT----GKLIATASADGTARIFSAATRKCIAKLE 342 Query: 337 GHNKGITALTVNP----LISGSYDGRIMEWSSSS 366 GH I+ ++ NP L++GS D W + + Sbjct: 343 GHEGEISKISFNPQGNHLLTGSSDKTARIWDAQT 376 Score = 35.8 bits (81), Expect = 0.050, Method: Compositional matrix adjust. Identities = 31/146 (21%), Positives = 61/146 (41%), Gaps = 10/146 (6%) Query: 221 FVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWD 280 ++T D+ +D +G+ + + + + F + + AT AD T R++ Sbjct: 275 LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYT---GKLIATASADGTARIFS 331 Query: 281 VTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNK 340 T KC+ K L+ + ++ GN +++ S D T ++ + L+ + GH Sbjct: 332 AATRKCIAK--LEGHEGEISKISFNPQGN-HLLTGSSDKTARIWDAQTGQCLQVLEGHTD 388 Query: 341 GITALTVNP----LISGSYDGRIMEW 362 I + N +I+GS D W Sbjct: 389 EIFSCAFNYKGNIVITGSKDNTCRIW 414 >2H9P-A nrPDB Length = 329 Score = 63.5 bits (153), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 77/314 (24%), Positives = 131/314 (41%), Gaps = 43/314 (13%) Query: 51 SKVPPV-----VQFT--GHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNS 103 SK PV ++FT GH + V++VKFSP ++L S + +WG +D + Sbjct: 21 SKPTPVKPNYALKFTLAGH-TKAVSSVKFSP--NGEWLASSSADKLIKIWG-AYDGKFE- 75 Query: 104 VEVNVKSEFQVLAGP---ISDISWDFEGRRLCVVGEGRDNFGVFISWD--SGNSLGEVSG 158 + ++G ISD++W + L + + WD SG L + G Sbjct: 76 ---------KTISGHKLGISDVAWSSDSNLLVSASDDK----TLKIWDVSSGKCLKTLKG 122 Query: 159 HSQRINACHLKQSRPMRSMTVGD--DGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSP 216 HS + C+ P ++ V D SV + K +T V V F+ Sbjct: 123 HSNYVFCCNF---NPQSNLIVSGSFDESVRIWD---VKTGKCLKTLPAHSDPVSAVHFNR 176 Query: 217 DSGEFVITVGSDRKISCFDGKSGEFLK-YIEDDQEPVQGGIFALSWLDSQKFATVGADAT 275 D G +++ D +D SG+ LK I+DD PV F+ + + D T Sbjct: 177 D-GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP---NGKYILAATLDNT 232 Query: 276 IRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTI 335 +++WD + KC++ +T K + TG I+S S D + + L E+++ + Sbjct: 233 LKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL 292 Query: 336 SGHNKGITALTVNP 349 GH + + +P Sbjct: 293 QGHTDVVISTACHP 306 Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 45/166 (27%), Positives = 82/166 (49%), Gaps = 19/166 (11%) Query: 209 VRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWL-DSQKF 267 V V+FSP+ GE++ + +D+ I + G+F K I + GI ++W DS Sbjct: 43 VSSVKFSPN-GEWLASSSADKLIKIWGAYDGKFEKTISGHKL----GISDVAWSSDSNLL 97 Query: 268 ATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGR---IISLSLDGTLNFY 324 + D T+++WDV++ KC+ K G+ N + I+S S D ++ + Sbjct: 98 VSASDDKTLKIWDVSSGKCL------KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 151 Query: 325 ELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSS 366 ++ + LKT+ H+ ++A+ N ++S SYDG W ++S Sbjct: 152 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS 197 Score = 52.0 bits (123), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 45/192 (23%), Positives = 84/192 (43%), Gaps = 22/192 (11%) Query: 200 RTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFAL 259 +T ++V F+P S +++ D + +D K+G+ LK + +PV F Sbjct: 118 KTLKGHSNYVFCCNFNPQS-NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNR 176 Query: 260 SWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVA-TGNGR-IISLSL 317 D + D R+WD + +C++ D N V V + NG+ I++ +L Sbjct: 177 ---DGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD----NPPVSFVKFSPNGKYILAATL 229 Query: 318 DGTLNFYELGHDEVLKTISGHNKGITALTVNP-------LISGSYDGRIMEWSSSSMH-- 368 D TL ++ + LKT +GH + N ++SGS D + W+ + Sbjct: 230 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 289 Query: 369 ---QDHSNLIVS 377 Q H+++++S Sbjct: 290 QKLQGHTDVVIS 301 >5M25-A nrPDB Length = 434 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 77/314 (24%), Positives = 130/314 (41%), Gaps = 43/314 (13%) Query: 51 SKVPPV-----VQFT--GHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGW---TFDKE 100 SK PV ++FT GH + V++VKFSP ++L S + +WG F+K Sbjct: 126 SKPTPVKPNYALKFTLAGH-TKAVSSVKFSP--NGEWLASSSADKLIKIWGAYDGKFEKT 182 Query: 101 SNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWD--SGNSLGEVSG 158 + ++ ISD++W + L + + WD SG L + G Sbjct: 183 ISGHKLG-----------ISDVAWSSDSNLLVSASDDK----TLKIWDVSSGKCLKTLKG 227 Query: 159 HSQRINACHLKQSRPMRSMTVGD--DGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSP 216 HS + C+ P ++ V D SV + K +T V V F+ Sbjct: 228 HSNYVFCCNF---NPQSNLIVSGSFDESVRIWD---VKTGKCLKTLPAHSDPVSAVHFNR 281 Query: 217 DSGEFVITVGSDRKISCFDGKSGEFLK-YIEDDQEPVQGGIFALSWLDSQKFATVGADAT 275 D G +++ D +D SG+ LK I+DD PV F+ + + D T Sbjct: 282 D-GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP---NGKYILAATLDNT 337 Query: 276 IRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTI 335 +++WD + KC++ +T K + TG I+S S D + + L E+++ + Sbjct: 338 LKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL 397 Query: 336 SGHNKGITALTVNP 349 GH + + +P Sbjct: 398 QGHTDVVISTACHP 411 Score = 57.8 bits (138), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 45/166 (27%), Positives = 82/166 (49%), Gaps = 19/166 (11%) Query: 209 VRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWL-DSQKF 267 V V+FSP+ GE++ + +D+ I + G+F K I + GI ++W DS Sbjct: 148 VSSVKFSPN-GEWLASSSADKLIKIWGAYDGKFEKTISGHKL----GISDVAWSSDSNLL 202 Query: 268 ATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGR---IISLSLDGTLNFY 324 + D T+++WDV++ KC+ K G+ N + I+S S D ++ + Sbjct: 203 VSASDDKTLKIWDVSSGKCL------KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 256 Query: 325 ELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSS 366 ++ + LKT+ H+ ++A+ N ++S SYDG W ++S Sbjct: 257 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS 302 >6N9G-C nrPDB Length = 353 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 71/318 (22%), Positives = 137/318 (43%), Gaps = 36/318 (11%) Query: 59 FTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVW-GWTFDKESNSVEVNVKSEFQVLAG 117 GHG+ V+ K + + S + GKVIVW +T +KE ++V + Sbjct: 59 LKGHGNKVLC---MDWCKDKRRIVSSSQDGKVIVWDSFTTNKE-HAVTMPCTWVMACAYA 114 Query: 118 PISDISWDFEGRRLCVVGEGRDN-FGVF-ISWDSGNSLG----EVSGHSQRINACHLKQS 171 P + G DN V+ +++D ++ V+ H+ ++AC S Sbjct: 115 PSG----------CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNS 164 Query: 172 RPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSP-DSGEFVITVGSDRK 230 M+ +T DG+ + + S H G+ V ++ +P ++G ++ G D+K Sbjct: 165 -DMQILTASGDGTCALWDVESGQLLQS---FHGHGADVLCLDLAPSETGNTFVSGGCDKK 220 Query: 231 ISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKW 290 +D +SG+ ++ E + V + S FA+ DAT R++D+ + V + Sbjct: 221 AMVWDMRSGQCVQAFETHESDVNSVRYYPS---GDAFASGSDDATCRLYDLRADREVAIY 277 Query: 291 TLDKQQLGNQQVGVVATGNGRIISLSL-DGTLNFYELGHDEVLKTISGHNKGITALTVNP 349 + + G V + +GR++ D T+N +++ + + GH ++ L V+P Sbjct: 278 SKESIIFGASSVDF--SLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSP 335 Query: 350 ----LISGSYDGRIMEWS 363 SGS+D + W+ Sbjct: 336 DGTAFCSGSWDHTLRVWA 353 Score = 35.0 bits (79), Expect = 0.10, Method: Compositional matrix adjust. Identities = 48/188 (25%), Positives = 75/188 (39%), Gaps = 16/188 (8%) Query: 222 VITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDV 281 ++T D + +D +SG+ L+ V A S F + G D VWD+ Sbjct: 168 ILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPS-ETGNTFVSGGCDKKAMVWDM 226 Query: 282 TTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTIS----- 336 + +CVQ + + + V +G+ S S D T Y+L D + S Sbjct: 227 RSGQCVQAFETHESDV--NSVRYYPSGDA-FASGSDDATCRLYDLRADREVAIYSKESII 283 Query: 337 -GHNKGITALTVNPLISGSYDGRIMEW-----SSSSMHQDHSNLIVSLDNS-KAQEYSSI 389 G + +L+ L +G D I W S S+ H N + +L S + S Sbjct: 284 FGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSG 343 Query: 390 SWDDTLKV 397 SWD TL+V Sbjct: 344 SWDHTLRV 351 >6Q8F-A nrPDB Length = 514 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 45/181 (24%), Positives = 83/181 (45%), Gaps = 14/181 (7%) Query: 194 KFSASDRTHHK--QGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEF---LKY-IED 247 KF H K Q S V FSPD G++++T D I ++ +G+ LKY +D Sbjct: 201 KFPTQLSRHIKFGQKSHVECARFSPD-GQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQD 259 Query: 248 DQEPVQGGIFALSW-LDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVA 306 + + + + + D++ AT D I+VW + + +C++++ ++ + Sbjct: 260 NFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRF--ERAHSKGVTCLSFS 317 Query: 307 TGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEW 362 + +I+S S D T+ + L + LK GH+ + T +IS S DG + W Sbjct: 318 KDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIW 377 Query: 363 S 363 + Sbjct: 378 N 378 >5FL8-q nrPDB Length = 515 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 98/460 (21%), Positives = 172/460 (37%), Gaps = 105/460 (22%) Query: 185 VVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKY 244 VF P + S++ H GS + F+P + ++T D +D Sbjct: 125 AVFKVKPVTRSSSAIAGH---GSTILCSAFAPHTSSRMVTGAGDNTARIWDC-------- 173 Query: 245 IEDDQEPVQ------GGIFALSW-LDSQKFATVGADATIRVWDVTTSKCV-------QKW 290 D Q P+ + +SW D + AT D TIR+WD + +C+ KW Sbjct: 174 --DTQTPMHTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKW 231 Query: 291 TLDKQQLGNQQVGVVATGNG-RIISLSLDGTLNFYELGHDEVLKTISGHNKGITALT--- 346 L + + +V G+ R+ S S DGT+ ++ T+SGH ++ + Sbjct: 232 I---TSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGG 288 Query: 347 VNPLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQ--EYSSISWDDTLKVNGITKHE 404 L SGS+D + W +S + +++ S A + S+S D L++ Sbjct: 289 QGLLYSGSHDRTVRVWDINSQGR-----CINILKSHAHWVNHLSLSTDYALRIGA----- 338 Query: 405 FGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLE 464 F K S + L +NY + + Sbjct: 339 FDHTGKKPSTPEEAQKKAL--------------------------------ENYEKICKK 366 Query: 465 EGNTIQVFKLSDLEVSFDLKTPLRA-KP-----------SYISISPSETYIAAGDVMGKI 512 GN+ ++ + + + L PL++ KP ++++ SP YI + I Sbjct: 367 NGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSI 426 Query: 513 LLYDLQSREVK-TSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVK 571 L+D R+ K S + H + + ++W + L+ + S DT + ++ V Sbjct: 427 KLWD--GRDGKFISTFRGHVASVYQVAWSSDCR----------LLVSCSKDTTLKVWDV- 473 Query: 572 RPMKIIKALNAHKDGVNNLLWETPSTLVSSGA-DACIKRW 610 R K+ L HKD V + W V SG D ++ W Sbjct: 474 RTRKLSVDLPGHKDEVYTVDWSVDGKRVCSGGKDKMVRLW 513 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 28/110 (25%), Positives = 49/110 (44%), Gaps = 8/110 (7%) Query: 177 MTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDG 236 +T DD ++ + P K + V V FSPD G ++++ D I +DG Sbjct: 375 VTASDDYTMFLWN--PLKSTKPIARMTGHQKLVNHVAFSPD-GRYIVSASFDNSIKLWDG 431 Query: 237 KSGEFLKYIEDDQEPVQGGIFALSW-LDSQKFATVGADATIRVWDVTTSK 285 + G+F+ ++ ++W D + + D T++VWDV T K Sbjct: 432 RDGKFISTFRGH----VASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTRK 477 Score = 37.4 bits (85), Expect = 0.020, Method: Compositional matrix adjust. Identities = 34/128 (26%), Positives = 50/128 (39%), Gaps = 31/128 (24%) Query: 499 SETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSK-----INAISWKPAEKGANEEEIEE 553 S AGD +I D Q+ HT K + +SW P + Sbjct: 157 SRMVTGAGDNTARIWDCDTQT--------PMHTLKGHYNWVLCVSWSP----------DG 198 Query: 554 DLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWE--------TPSTLVSSGADA 605 +++ATGS+D I ++ K + AL H + +L WE + L SS D Sbjct: 199 EVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDG 258 Query: 606 CIKRWNVV 613 IK W+ V Sbjct: 259 TIKIWDTV 266 Score = 32.7 bits (73), Expect = 0.43, Method: Compositional matrix adjust. Identities = 33/141 (23%), Positives = 61/141 (43%), Gaps = 18/141 (12%) Query: 482 DLKTPLRAKPSY------ISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKIN 535 D +TP+ + +S SP IA G + I L+D +S + H+ I Sbjct: 174 DTQTPMHTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWIT 233 Query: 536 AISWKP---AEKGANEEEIEEDLVATGSLDTNIFIY-SVKRPMKIIKALNAHKDGVNNLL 591 ++SW+P + G+ +A+ S D I I+ +V R + ++ H + V+ + Sbjct: 234 SLSWEPIHLVKPGSKPR------LASSSKDGTIKIWDTVSRVCQY--TMSGHTNSVSCVK 285 Query: 592 WETPSTLVSSGADACIKRWNV 612 W L S D ++ W++ Sbjct: 286 WGGQGLLYSGSHDRTVRVWDI 306 >6MZM-G nrPDB Length = 800 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 46/176 (26%), Positives = 82/176 (46%), Gaps = 31/176 (17%) Query: 209 VRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFA--LSWLDSQK 266 V D +FSP G + ++ G DR + D +P++ IFA L+ ++ + Sbjct: 588 VWDTQFSP-YGYYFVSGGHDRVARL----------WATDHYQPLR--IFAGHLADVNCTR 634 Query: 267 F-------ATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISL-SLD 318 F AT AD T+R+WDV CV+ +T K + + + + NGR ++ + D Sbjct: 635 FHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHS----LTFSPNGRFLATGATD 690 Query: 319 GTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQD 370 G + +++GH ++ + GH + +L + L SGS D + W + +D Sbjct: 691 GRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFED 746 >6F3T-A nrPDB Length = 608 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 56/236 (23%), Positives = 103/236 (43%), Gaps = 35/236 (14%) Query: 149 SGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSF 208 + + L + GHS + R ++ +DG+V + F + H+ Sbjct: 340 TASELKILYGHSGPVYGASFSPDRNYL-LSSSEDGTVRLWSLQTFTCLVGYKGHNYP--- 395 Query: 209 VRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFA--LSWLDSQK 266 V D +FSP G + ++ G DR + D +P++ IFA L+ ++ + Sbjct: 396 VWDTQFSP-YGYYFVSGGHDRVARL----------WATDHYQPLR--IFAGHLADVNCTR 442 Query: 267 F-------ATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISL-SLD 318 F AT AD T+R+WDV CV+ +T K + + + + NGR ++ + D Sbjct: 443 FHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHS----LTFSPNGRFLATGATD 498 Query: 319 GTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQD 370 G + +++GH ++ + GH + +L + L SGS D + W + +D Sbjct: 499 GRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFED 554 >6QX9-4B nrPDB Length = 522 Score = 50.1 bits (118), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 54/202 (26%), Positives = 91/202 (45%), Gaps = 22/202 (10%) Query: 209 VRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFA 268 V V + P SG F+ T DR +D ++ E + + QE G++ +++ A Sbjct: 326 VARVMWHP-SGRFLGTTCYDRSWRLWDLEAQEEILH----QEGHSMGVYDIAFHQDGSLA 380 Query: 269 -TVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNG-RIISLSLDGTLNFYEL 326 T G DA RVWD+ T +C+ +++ G+ + NG I + S D T ++L Sbjct: 381 GTGGLDAFGRVWDLRTGRCIMFLEGHLKEI----YGINFSPNGYHIATGSGDNTCKVWDL 436 Query: 327 GHDEVLKTISGHNKGITALTVNP-----LISGSYD--GRIME---WSSSSMHQDHSNLIV 376 + TI H +T + P L++G+YD +I WS H ++ Sbjct: 437 RQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVM 496 Query: 377 SLD-NSKAQEYSSISWDDTLKV 397 LD +S Q ++ S+D T K+ Sbjct: 497 GLDISSDGQLIATCSYDRTFKL 518 >5FVM-C nrPDB Length = 303 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 70/307 (22%), Positives = 115/307 (37%), Gaps = 61/307 (19%) Query: 43 VRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESN 102 VR D + PV F GH +V T++ F + ++++ S E G + VW D S Sbjct: 55 VRLYDIRSNNPNPVSSFEGHKGNV-TSIAFQ--QENRWMVSSSEDGTIKVW----DVRSP 107 Query: 103 SVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDS-GNSLGEVSGHSQ 161 SV+ N K P+++++ N G IS D GN G +Q Sbjct: 108 SVQRNYKHN-----APVNEVA-------------IHPNQGELISCDQDGNIRIWDLGENQ 149 Query: 162 RINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEF 221 N + + P++S++V DGS++ HH S + V Sbjct: 150 CTNQLTPEDNTPLQSLSVASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVT-------- 201 Query: 222 VITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDV 281 K KYI L D + AT AD T RVW++ Sbjct: 202 ---------------KFKSHTKYI----------TRVLLSADVKNLATCSADHTARVWNI 236 Query: 282 TTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKG 341 + ++ TLD Q A + +++ D + ++L E+++ GH+KG Sbjct: 237 EDNYQLET-TLDGHQRWVWDCAFSA-DSAYLVTACSDHYVRLWDLSTSEIVRQYGGHHKG 294 Query: 342 ITALTVN 348 + +N Sbjct: 295 AVCVALN 301 Score = 31.6 bits (70), Expect = 0.94, Method: Compositional matrix adjust. Identities = 29/109 (26%), Positives = 49/109 (44%), Gaps = 14/109 (12%) Query: 273 DATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVAT--GNGRIISLSLDGTLNFYELGHDE 330 D TI+VWDV + ++ + N V VA G +IS DG + ++LG ++ Sbjct: 96 DGTIKVWDVRSP------SVQRNYKHNAPVNEVAIHPNQGELISCDQDGNIRIWDLGENQ 149 Query: 331 VLKTISGH-NKGITALTV----NPLISGSYDGRIMEWSSSSMHQDHSNL 374 ++ N + +L+V + L++G+ G W H D S L Sbjct: 150 CTNQLTPEDNTPLQSLSVASDGSMLVAGNNKGNCYVWRMPH-HTDASTL 197 >6ID0-T nrPDB Length = 514 Score = 47.0 bits (110), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 44/164 (26%), Positives = 73/164 (44%), Gaps = 20/164 (12%) Query: 207 SFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQK 266 S VR V S S ++ + G D+++ C+D + + +++ G + A+ LD Sbjct: 247 STVRGVIVSTRS-PYLFSCGEDKQVKCWDLEYNKVIRHY-------HGHLSAVYGLDLHP 298 Query: 267 ----FATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLN 322 T D+T R+WDV T V TL V A +II+ S D T+ Sbjct: 299 TIDVLVTCSRDSTARIWDVRTKASVH--TLSGHTNAVATVRCQA-AEPQIITGSHDTTIR 355 Query: 323 FYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEW 362 ++L + T++ H K + A+ ++P SGS D I +W Sbjct: 356 LWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQW 398 Score = 38.5 bits (88), Expect = 0.010, Method: Compositional matrix adjust. Identities = 30/130 (23%), Positives = 62/130 (47%), Gaps = 12/130 (9%) Query: 264 SQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNF 323 +Q F T AD TI++WD+ + K T + + +V+T + + S D + Sbjct: 216 NQWFVTGSADRTIKIWDLASGKLKLSLT---GHISTVRGVIVSTRSPYLFSCGEDKQVKC 272 Query: 324 YELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEW---SSSSMH--QDHSNL 374 ++L +++V++ GH + L ++P L++ S D W + +S+H H+N Sbjct: 273 WDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNA 332 Query: 375 IVSLDNSKAQ 384 + ++ A+ Sbjct: 333 VATVRCQAAE 342 >3DM0-A nrPDB Length = 694 Score = 45.8 bits (107), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 44/177 (24%), Positives = 83/177 (46%), Gaps = 16/177 (9%) Query: 195 FSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQG 254 + + R FV DV S D G+F ++ D ++ +D +G + + V Sbjct: 419 YGVAQRRLTGHSHFVEDVVLSSD-GQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLS 477 Query: 255 GIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQ-VGVVA----TGN 309 F+L D+++ + D TI++W+ T +C K+T+ + G++ V V T Sbjct: 478 VAFSL---DNRQIVSASRDRTIKLWN-TLGEC--KYTISEGGEGHRDWVSCVRFSPNTLQ 531 Query: 310 GRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEW 362 I+S S D T+ + L + ++ T++GH ++ + V+P SG DG ++ W Sbjct: 532 PTIVSASWDKTVKVWNLSNCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLW 588 Score = 32.0 bits (71), Expect = 0.71, Method: Compositional matrix adjust. Identities = 76/339 (22%), Positives = 135/339 (39%), Gaps = 83/339 (24%) Query: 312 IISLSLDGTLNFYELGHDE-----VLKTISGHNKGITALTVNP----LISGSYDGRIMEW 362 I+S S D ++ ++L D+ + ++GH+ + + ++ +SGS+DG + W Sbjct: 398 IVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVLSSDGQFALSGSWDGELRLW 457 Query: 363 SSSS---------MHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVAS 413 ++ +D ++ SLDN ++ S S D T+K+ + G S Sbjct: 458 DLAAGVSTRRFVGHTKDVLSVAFSLDN---RQIVSASRDRTIKL----WNTLGECKYTIS 510 Query: 414 ANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFK 473 +G D + VR SP + L V+ ++ T++V+ Sbjct: 511 EGGEGHR-----------------DWVSCVRF-SPNT---LQPTIVSASWDK--TVKVWN 547 Query: 474 LSDLEVSFDLKTPLRAKPSYIS---ISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFH 530 LS+ + L++ L Y+S +SP + A+G G +LL+DL + S A Sbjct: 548 LSNCK----LRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEA-- 601 Query: 531 TSKINAISWKP-----------------AEKGANEEEIEEDLVATGSLDTNIFIYSVKRP 573 S I+A+ + P E + E+++ DL A N + KR Sbjct: 602 NSVIHALCFSPNRYWLCAATEHGIKIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKRK 661 Query: 574 MKIIKALNAHKDGVNNLLWETPSTLVSSGADACIKRWNV 612 + +LN DG STL S D I+ W + Sbjct: 662 VIYCTSLNWSADG---------STLFSGYTDGVIRVWGI 691 >6QX9-5O nrPDB Length = 357 Score = 45.4 bits (106), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 68/317 (21%), Positives = 134/317 (42%), Gaps = 35/317 (11%) Query: 55 PVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQV 114 P++ +GH V KF P GS +G + +++W D ++ + + Sbjct: 58 PIMLLSGHEGEVYC-CKFHP-NGSTLASAGFDR-LILLWNVYGDCDNYAT-------LKG 107 Query: 115 LAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDS--GNSLGEVSGHSQRINACHLKQSR 172 +G + ++ ++ +G L + WDS G + + GH+ +N+C+ + Sbjct: 108 HSGAVMELHYNTDGSMLFSASTDK----TVAVWDSETGERVKRLKGHTSFVNSCYPARRG 163 Query: 173 PMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSF-VRDVEFSPDSGEFVITVGSDRKI 231 P T DDG+V + + A+ +T Q ++ V V F+ D+ + +I+ G D I Sbjct: 164 PQLVCTGSDDGTVKLWD---IRKKAAIQTF--QNTYQVLAVTFN-DTSDQIISGGIDNDI 217 Query: 232 SCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVT----TSKCV 287 +D + + + + V G +LS + + D T+RVWDV +CV Sbjct: 218 KVWDLRQNKLTYTMRGHADSVTG--LSLS-SEGSYLLSNAMDNTVRVWDVRPFAPKERCV 274 Query: 288 QKWTLDKQQLGNQQVGVVATGNG-RIISLSLDGTLNFYELGHDEVLKTISGHNKGITALT 346 + + + + + +G +I + S D + ++ +L + GH I + Sbjct: 275 KIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVA 334 Query: 347 VNP----LISGSYDGRI 359 +P +IS S D R+ Sbjct: 335 FHPDEPIIISASSDKRL 351 >5WYJ-BC nrPDB Length = 817 Score = 45.1 bits (105), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 39/173 (22%), Positives = 75/173 (43%), Gaps = 13/173 (7%) Query: 195 FSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQG 254 S+ T H + + SP+ F T D+ ++ ++GE + + + Sbjct: 480 IKVSEYTRHAHEKDINALSVSPNDSIFA-TASYDKTCKIWNLENGELEATLANHKR---- 534 Query: 255 GIFALSWLDSQKF-ATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRII 313 G++ +S+ K AT D T+++W + T ++ TL+ Q+ + ++I Sbjct: 535 GLWDVSFCQYDKLLATSSGDKTVKIWSLDTFSVMK--TLEGHTNAVQRCSFI-NKQKQLI 591 Query: 314 SLSLDGTLNFYELGHDEVLKTISGHNKGITALTV----NPLISGSYDGRIMEW 362 S DG + ++ E LKT+ GHN + AL+ + ++S DG W Sbjct: 592 SCGADGLIKIWDCSSGECLKTLDGHNNRLWALSTMNDGDMIVSADADGVFQFW 644 Score = 31.2 bits (69), Expect = 1.3, Method: Compositional matrix adjust. Identities = 29/119 (24%), Positives = 55/119 (46%), Gaps = 13/119 (10%) Query: 494 ISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEE 553 +S+SP+++ A +++L++ E++ + A H + +S+ +K Sbjct: 497 LSVSPNDSIFATASYDKTCKIWNLENGELEAT-LANHKRGLWDVSFCQYDK--------- 546 Query: 554 DLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNL-LWETPSTLVSSGADACIKRWN 611 L+AT S D + I+S+ ++K L H + V L+S GAD IK W+ Sbjct: 547 -LLATSSGDKTVKIWSLD-TFSVMKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWD 603 >6HHQ-h nrPDB Length = 319 Score = 45.1 bits (105), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 51/225 (22%), Positives = 89/225 (39%), Gaps = 26/225 (11%) Query: 154 GEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQ--GPPFKFSASDRTHHKQGSFVRD 211 G + GH+ + + +P ++ D +++ ++ G KF R+ V+D Sbjct: 11 GTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQD 70 Query: 212 VEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATV- 270 + D G + ++ D+ + +D +GE + + V +D K A++ Sbjct: 71 CTLTAD-GAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMS-------VDIDKKASMI 122 Query: 271 ---GADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNG-----RIISLSLDGTLN 322 D TI+VW + +C+ TL QV VV IIS D + Sbjct: 123 ISGSRDKTIKVWTIK-GQCLA--TLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVK 179 Query: 323 FYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWS 363 + L ++ GHN I LT +P + S DG IM W+ Sbjct: 180 AWNLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWN 224 Score = 32.3 bits (72), Expect = 0.58, Method: Compositional matrix adjust. Identities = 53/232 (22%), Positives = 100/232 (43%), Gaps = 39/232 (16%) Query: 326 LGHDEVL---KTISGHNKGITALTV-----NPLISGSYDGRIMEWSSSSMHQD------- 370 + +EVL T+ GHN +T+L N L+S S D ++ W + Q Sbjct: 1 MASNEVLVLRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRS 60 Query: 371 ---HSNLIVSLDNSKAQEYS-SISWDDTLKV----NGITKHEF-GSQPKVASANNDG-FT 420 HS+++ + Y+ S SWD TL++ G T F G + V S + D + Sbjct: 61 FKGHSHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKAS 120 Query: 421 AVLTNDDDLLI---------LQSFTG--DIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTI 469 +++ D I L + G D + VR+ A S ++ G ++ + Sbjct: 121 MIISGSRDKTIKVWTIKGQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDK--MV 178 Query: 470 QVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSRE 521 + + L+ ++ D + + ++ SP T IA+ G+I+L++L +++ Sbjct: 179 KAWNLNQFQIEADF-IGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKK 229 >5Y88-O nrPDB Length = 451 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 33/142 (23%), Positives = 67/142 (47%), Gaps = 9/142 (6%) Query: 209 VRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKF- 267 VRDV S D ++ +V D+ + C+D + + ++ D G+ +S + Sbjct: 185 VRDVAVS-DRHPYLFSVSEDKTVKCWDLEKNQIIR----DYYGHLSGVRTVSIHPTLDLI 239 Query: 268 ATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELG 327 AT G D+ I++WD+ T V K + Q V + +++S S D T+ +++ Sbjct: 240 ATAGRDSVIKLWDMRTRIPVITLVGHKGPINQVQCTPV---DPQVVSSSTDATVRLWDVV 296 Query: 328 HDEVLKTISGHNKGITALTVNP 349 + +K ++ H + + A ++P Sbjct: 297 AGKTMKVLTHHKRSVRATALHP 318 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 25/94 (26%), Positives = 52/94 (55%), Gaps = 3/94 (3%) Query: 258 ALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSL 317 A+ +D++ F T D T++VWD+ T K K TL + + V V+ + + S+S Sbjct: 146 AIDPVDNEWFITGSNDTTMKVWDLATGKL--KTTLAGHVMTVRDVA-VSDRHPYLFSVSE 202 Query: 318 DGTLNFYELGHDEVLKTISGHNKGITALTVNPLI 351 D T+ ++L +++++ GH G+ ++++P + Sbjct: 203 DKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTL 236 Score = 32.0 bits (71), Expect = 0.90, Method: Compositional matrix adjust. Identities = 29/122 (23%), Positives = 56/122 (45%), Gaps = 15/122 (12%) Query: 494 ISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEE 553 +++S Y+ + + +DL+ ++ + H S + +S P Sbjct: 188 VAVSDRHPYLFSVSEDKTVKCWDLEKNQIIRDYYG-HLSGVRTVSIHPTL---------- 236 Query: 554 DLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETP--STLVSSGADACIKRWN 611 DL+AT D+ I ++ ++ + +I L HK +N + TP +VSS DA ++ W+ Sbjct: 237 DLIATAGRDSVIKLWDMRTRIPVI-TLVGHKGPINQVQC-TPVDPQVVSSSTDATVRLWD 294 Query: 612 VV 613 VV Sbjct: 295 VV 296 >6GMH-W nrPDB Length = 305 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 39/137 (28%), Positives = 72/137 (52%), Gaps = 12/137 (8%) Query: 228 DRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCV 287 D I +D ++G+ +K I D PV A S DSQ AT + ++ V + K Sbjct: 85 DAHIRLWDLENGKQIKSI--DAGPVDAWTLAFS-PDSQYLATGTHVGKVNIFGVESGK-- 139 Query: 288 QKWTLDKQQLGNQQVGVVATGNGRII-SLSLDGTLNFYELGHDEVLKTISGHNKGITALT 346 ++++LD + G + + + +G+ + S ++DG +N +++ ++L T+ GH I +LT Sbjct: 140 KEYSLDTR--GKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLT 197 Query: 347 VNP----LISGSYDGRI 359 +P L++ S DG I Sbjct: 198 FSPDSQLLVTASDDGYI 214 Score = 38.1 bits (87), Expect = 0.012, Method: Compositional matrix adjust. Identities = 39/164 (23%), Positives = 64/164 (39%), Gaps = 51/164 (31%) Query: 205 QGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDS 264 +G F+ + +SPD G+++ + D I+ FD +G+ L +E P++ F+ DS Sbjct: 147 RGKFILSIAYSPD-GKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSP---DS 202 Query: 265 QKFATVGADATIRV------------------------------------------WDVT 282 Q T D I++ WDV Sbjct: 203 QLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVG 262 Query: 283 TSKCVQKWTLDKQQLGNQQVGVVATGNG-RIISLSLDGTLNFYE 325 T CV + D Q +Q GV GNG +I+S+ D ++ Y+ Sbjct: 263 TRTCVHTF-FDHQ---DQVWGVKYNGNGSKIVSVGDDQEIHIYD 302 Score = 35.0 bits (79), Expect = 0.11, Method: Compositional matrix adjust. Identities = 38/153 (24%), Positives = 59/153 (38%), Gaps = 16/153 (10%) Query: 69 TVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEG 128 T+ FSP SQYL +G GKV ++G K+ S++ K + P +G Sbjct: 111 TLAFSP--DSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSP--------DG 160 Query: 129 RRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFY 188 + L D +G L + GH+ I + + +T DDG + Y Sbjct: 161 KYLA--SGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLL-VTASDDGYIKIY 217 Query: 189 QGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEF 221 + + H S+V +V F PD F Sbjct: 218 DVQHANLAGTLSGH---ASWVLNVAFCPDDTHF 247 Score = 33.5 bits (75), Expect = 0.26, Method: Compositional matrix adjust. Identities = 33/139 (23%), Positives = 68/139 (48%), Gaps = 9/139 (6%) Query: 212 VEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVG 271 + FSPDS +++ T K++ F +SG+ +Y D + I ++++ K+ G Sbjct: 112 LAFSPDS-QYLATGTHVGKVNIFGVESGK-KEYSLDTRGKF---ILSIAYSPDGKYLASG 166 Query: 272 A-DATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDE 330 A D I ++D+ T K + TL+ + + + + + +++ S DG + Y++ H Sbjct: 167 AIDGIINIFDIATGKLLH--TLEGHAMPIRSL-TFSPDSQLLVTASDDGYIKIYDVQHAN 223 Query: 331 VLKTISGHNKGITALTVNP 349 + T+SGH + + P Sbjct: 224 LAGTLSGHASWVLNVAFCP 242 Score = 30.4 bits (67), Expect = 2.1, Method: Compositional matrix adjust. Identities = 38/148 (25%), Positives = 71/148 (47%), Gaps = 23/148 (15%) Query: 472 FKLSDLEVSFDLKTPLRAKPS---YISISPSETYIAAGDVMGKILLYDLQSREVKTS--- 525 +L DLE +K+ + A P ++ SP Y+A G +GK+ ++ ++S + + S Sbjct: 88 IRLWDLENGKQIKS-IDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDT 146 Query: 526 RWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKD 585 R F I +I++ P K +A+G++D I I+ + K++ L H Sbjct: 147 RGKF----ILSIAYSPDGK----------YLASGAIDGIINIFDIATG-KLLHTLEGHAM 191 Query: 586 GVNNLLWETPST-LVSSGADACIKRWNV 612 + +L + S LV++ D IK ++V Sbjct: 192 PIRSLTFSPDSQLLVTASDDGYIKIYDV 219 >5Z56-q nrPDB Length = 504 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 48/195 (24%), Positives = 87/195 (44%), Gaps = 19/195 (9%) Query: 212 VEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFA-TV 270 ++ P ++T G+D+ + FD S + L ++ + V +F SQ + Sbjct: 227 LDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFH----PSQDLVFSA 282 Query: 271 GADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDE 330 DATIR+W V + CVQ + + + + ATG+ ++S S D F ++ Sbjct: 283 SPDATIRIWSVPNASCVQ--VVRAHESAVTGLSLHATGD-YLLSSSDDQYWAFSDIQTGR 339 Query: 331 VLKTISGHNKG--ITALTVNP--LI--SGSYDGRIMEW-----SSSSMHQDHSNLIVSLD 379 VL ++ G +T +P LI +G+ D +I W ++ + HS I S+ Sbjct: 340 VLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIA 399 Query: 380 NSKAQEYSSISWDDT 394 S+ Y + + DD+ Sbjct: 400 FSENGYYLATAADDS 414 >3JB9-S nrPDB Length = 488 Score = 42.7 bits (99), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 64/261 (24%), Positives = 110/261 (42%), Gaps = 40/261 (15%) Query: 215 SPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADA 274 SP++ FV+ + D ++ C D +S LK E G A WL S K A ADA Sbjct: 218 SPENSSFVLCLHKD-ELLCLDIQSNSTLKIFE-------GSALACCWLTSSKIAVATADA 269 Query: 275 TIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKT 334 I +++ S G Q VG + S+ +D +NF + H Sbjct: 270 -ISIFEFPVSSS-----------GLQSVGEPTS------SIPIDEKVNFLQ-AHPSGEYL 310 Query: 335 ISGHNKGITALTVNPLISGSYDGRIMEW-SSSSMHQDHSNLIVSLDNSKAQEYSSISWDD 393 ++ N+ + L S Y+ + + +S ++H D + + L+N + + + + Sbjct: 311 LAASNEKCYIFS---LKSQVYNITVAQHITSLAVHPDGNLFVAGLENGELRFF------E 361 Query: 394 TLKVNGITKHEFGSQP-KVASANNDGF-TAVLTNDD-DLLILQSFTGDIIKSVRLNSPGS 450 T N +TK S P K +G+ V TNDD D+ I ++++ + L + + Sbjct: 362 TSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKSELVQKIPLQTKVA 421 Query: 451 AVSLSQNYVAVGLEEGNTIQV 471 AVSL + +G T+ V Sbjct: 422 AVSLDITSQLLVSSDGETLYV 442 >6ELZ-p nrPDB Length = 460 Score = 42.7 bits (99), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 72/328 (21%), Positives = 131/328 (39%), Gaps = 65/328 (19%) Query: 77 GSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGE 136 GS+++ SG G V W + NV+ ++ +GPI + + RL G Sbjct: 114 GSKHIISGSYDGIVRTW---------DLSGNVQKQYSGHSGPIRAVKY-ISNTRLVSAGN 163 Query: 137 GR---------DNFGV------------FISWDSGNSLGEVSGHSQRINACHLKQSRPMR 175 R D+ + ++ + G +L + GH + + S R Sbjct: 164 DRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPV--VSIDVSDNSR 221 Query: 176 SMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDR-KISCF 234 ++ D S+ F+ T +K+ + V +E + + T R K++ Sbjct: 222 ILSASYDNSIGFWS-----------TIYKEMTVVDPLEDINNPNNKISTAARKRRKLTMK 270 Query: 235 DG--KSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTL 292 DG + L +E PV+ IF + D+ +V D TI+ WD+ T++C+ T Sbjct: 271 DGTIRRRAPLSLLESHTAPVEQVIFDST--DNTVGYSVSQDHTIKTWDLVTARCIDTRTT 328 Query: 293 DKQQLGNQQ---VGVVATG-NGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVN 348 L Q + ++A G + R I+L ++ +++ GH +++L Sbjct: 329 SYSLLSIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQLI----GHKNFVSSLDTC 384 Query: 349 P-----LISGSYDGRIMEW---SSSSMH 368 P L SGS+DG + W S+S M+ Sbjct: 385 PENEYILCSGSHDGTVKVWDVRSTSPMY 412 Score = 28.9 bits (63), Expect = 7.8, Method: Compositional matrix adjust. Identities = 19/77 (24%), Positives = 39/77 (50%), Gaps = 6/77 (7%) Query: 207 SFVRDVEFSPDSGEFVITVGS-DRKISCFDGKSGEFLKYIEDDQEPVQGGI----FALSW 261 +FV ++ P++ E+++ GS D + +D +S + I + + VQ G+ FA+ W Sbjct: 376 NFVSSLDTCPEN-EYILCSGSHDGTVKVWDVRSTSPMYTITREDKSVQKGVNDKVFAVKW 434 Query: 262 LDSQKFATVGADATIRV 278 + + G D I++ Sbjct: 435 AEKVGIISAGQDKKIQI 451 >5K1B-B nrPDB Length = 677 Score = 42.7 bits (99), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 41/164 (25%), Positives = 71/164 (43%), Gaps = 13/164 (7%) Query: 200 RTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDD--QEPVQGGIF 257 RTH +V+ + ++ D E V + G DR+I +D + L + + G Sbjct: 114 RTHK---DYVKALAYAKDK-ELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKD 169 Query: 258 ALSWLDSQKFATV----GADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRII 313 ++ L + T+ + +RVWD T C + L K N + ++ + + Sbjct: 170 SIYSLAMNQLGTIIVSGSTEKVLRVWDPRT--CAKLMKL-KGHTDNVKALLLNRDGTQCL 226 Query: 314 SLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPLISGSYDG 357 S S DGT+ + LG + T H++G+ AL VN + Y G Sbjct: 227 SGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSG 270 Score = 37.0 bits (84), Expect = 0.023, Method: Compositional matrix adjust. Identities = 38/152 (25%), Positives = 63/152 (41%), Gaps = 18/152 (11%) Query: 143 VFISWD--SGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDR 200 V WD + L ++ GH+ + A L + + ++ DG++ + + A+ R Sbjct: 191 VLRVWDPRTCAKLMKLKGHTDNVKALLLNRD-GTQCLSGSSDGTIRLWSLGQQRCIATYR 249 Query: 201 THHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALS 260 H +G + V D+ V + G DRKI C D ++ + I +++ PV S Sbjct: 250 VH-DEGVWALQVN---DAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDRS 305 Query: 261 WLDSQKFATVGADATIRVWDVTTSKCVQKWTL 292 AD +W TT V KWTL Sbjct: 306 -----------ADPPPAIWVATTKSTVNKWTL 326 >4LG8-A nrPDB Length = 354 Score = 42.4 bits (98), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 48/195 (24%), Positives = 87/195 (44%), Gaps = 19/195 (9%) Query: 212 VEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFA-TV 270 ++ P ++T G+D+ + FD S + L ++ + V +F SQ + Sbjct: 77 LDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFH----PSQDLVFSA 132 Query: 271 GADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDE 330 DATIR+W V + CVQ + + + + ATG+ ++S S D F ++ Sbjct: 133 SPDATIRIWSVPNASCVQ--VVRAHESAVTGLSLHATGD-YLLSSSDDQYWAFSDIQTGR 189 Query: 331 VLKTISGHNKG--ITALTVNP--LI--SGSYDGRIMEW-----SSSSMHQDHSNLIVSLD 379 VL ++ G +T +P LI +G+ D +I W ++ + HS I S+ Sbjct: 190 VLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIA 249 Query: 380 NSKAQEYSSISWDDT 394 S+ Y + + DD+ Sbjct: 250 FSENGYYLATAADDS 264 >4V6W-Ag nrPDB Length = 318 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 43/201 (21%), Positives = 94/201 (46%), Gaps = 18/201 (8%) Query: 208 FVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKF 267 F+ DV S D G + ++ D+ + +D +G+ + E + V F+ D+++ Sbjct: 66 FISDVVLSSD-GNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSA---DNRQI 121 Query: 268 ATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGR---IISLSLDGTLNFY 324 + D TI++W+ T ++C K+T+ + + V + N I+S D T+ + Sbjct: 122 VSGSRDKTIKLWN-TLAEC--KFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVW 178 Query: 325 ELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQ----DHSNLIV 376 L + ++ GHN + +TV+P SG D + + W + +H+++I Sbjct: 179 NLANCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLEHNDIIN 238 Query: 377 SLDNSKAQEYSSISWDDTLKV 397 +L S + + +++ ++K+ Sbjct: 239 ALCFSPNRYWLCVAYGPSIKI 259 Score = 29.6 bits (65), Expect = 4.3, Method: Compositional matrix adjust. Identities = 56/242 (23%), Positives = 96/242 (39%), Gaps = 41/242 (16%) Query: 334 TISGHNKGITALTVNP-----LISGSYDGRIMEWSSSSMHQD-----------HSNLIVS 377 T+ GHN +T + NP +IS S D ++ W + HS+ I Sbjct: 10 TLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISD 69 Query: 378 LDNSKAQEYS-SISWDDTLKV----NGITKHEFGSQPK---VASANNDGFTAVLTNDDDL 429 + S Y+ S SWD TL++ G T F K + + D V + D Sbjct: 70 VVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQIVSGSRDKT 129 Query: 430 LILQSFTGDIIKSVRLNSPG---SAVSLSQNY---VAVGLEEGNTIQVFKLSDLEVSFDL 483 + L + + +++ + S V S N+ + V T++V+ L++ + L Sbjct: 130 IKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCK----L 185 Query: 484 KTPLRAKPSY---ISISPSETYIAAGDVMGKILLYDLQ-SREVKTSRWAFHTSKINAISW 539 K Y +++SP + +G K LL+DL + + T H INA+ + Sbjct: 186 KNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLE---HNDIINALCF 242 Query: 540 KP 541 P Sbjct: 243 SP 244 >3JB9-L nrPDB Length = 340 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 39/161 (24%), Positives = 71/161 (44%), Gaps = 23/161 (14%) Query: 209 VRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLD--SQK 266 + D+++S DS V SD + +D SG+ ++ + G + AL L S+ Sbjct: 96 ITDLQWSRDS-RVVYCSSSDTHLMSWDAVSGQKIR----KHKGHAGVVNALDVLKVGSEL 150 Query: 267 FATVGADATIRVWDVTTSKCV----QKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLN 322 +V D T++VWD + C+ +K+ L + Q V G +DG + Sbjct: 151 LTSVSDDCTMKVWDSRSKDCIKTIEEKYPLTAVAIAQQGTQVFIGG--------IDGAIK 202 Query: 323 FYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRI 359 ++L ++ + GH IT+L ++ L+S S D + Sbjct: 203 IWDLRNNHCSHVLKGHKDIITSLAISKDGSSLLSNSMDNTV 243 Score = 30.0 bits (66), Expect = 3.5, Method: Compositional matrix adjust. Identities = 17/58 (29%), Positives = 29/58 (50%), Gaps = 1/58 (1%) Query: 557 ATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLV-SSGADACIKRWNVV 613 A+G +D I +++V +K LN K + +L W S +V S +D + W+ V Sbjct: 66 ASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQWSRDSRVVYCSSSDTHLMSWDAV 123 >2YNP-A nrPDB Length = 604 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 44/175 (25%), Positives = 74/175 (42%), Gaps = 22/175 (12%) Query: 263 DSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLN 322 D FA+ D T++VW + S T +++ N +I+ S D T+ Sbjct: 152 DPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIK 211 Query: 323 FYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQDHSNLIVSL 378 ++ + T+ GH ++ +P +ISGS DG + W+SS+ ++ L V L Sbjct: 212 IWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSST-YKVEKTLNVGL 270 Query: 379 DNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAV-LTNDDDLLIL 432 + S I H G + +AS ++GFT + L ND+ L L Sbjct: 271 ERSWC----------------IATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSL 309 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 65/275 (23%), Positives = 113/275 (41%), Gaps = 22/275 (8%) Query: 64 SSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDIS 123 S V + F P + ++ + SG+V +W + E S++V +E V AG Sbjct: 13 SDRVKGIDFHPTE--PWVLTTLYSGRVELWNYETQVEVRSIQV---TETPVRAGK----- 62 Query: 124 WDFEGRRLCVVGEGRDNFGVFI-SWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDD 182 F R+ ++ G D+F + + ++++G + + H I + + ++P ++ DD Sbjct: 63 --FIARKNWII-VGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPY-VLSGSDD 118 Query: 183 GSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFD-GKSGEF 241 +V + A ++T FV V F+P + DR + + G+S Sbjct: 119 LTVKLWNWE--NNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPN 176 Query: 242 LKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQ 301 + QE + D T D TI++WD T CV TL+ + N Sbjct: 177 FT-LTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVA--TLEG-HMSNVS 232 Query: 302 VGVVATGNGRIISLSLDGTLNFYELGHDEVLKTIS 336 V IIS S DGTL + +V KT++ Sbjct: 233 FAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLN 267 >4YCZ-A nrPDB Length = 876 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 33/117 (28%), Positives = 53/117 (45%), Gaps = 18/117 (15%) Query: 489 AKPSYISISPSETYIAAGDVMGKILLY-DLQSREVKTSRWAFHTSKINAISWKPAEKGAN 547 A P Y +I S Y GK+L++ +L + +A H + +N +SW P E G Sbjct: 71 AHPKYGNILASAGYD------GKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGC- 123 Query: 548 EEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWE---TPSTLVSS 601 L+A S D N+ + + +AH GVN++ W +P ++VSS Sbjct: 124 -------LLACASSDGNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSS 173 >3MKQ-A nrPDB Length = 814 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 45/175 (25%), Positives = 75/175 (42%), Gaps = 22/175 (12%) Query: 263 DSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLN 322 D FA+ D T++VW + S T +++ N +I+ S D T+ Sbjct: 152 DPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIK 211 Query: 323 FYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQDHSNLIVSL 378 ++ + T+ GH ++ +P +ISGS DG + W+SS+ ++ L V L Sbjct: 212 IWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSST-YKVEKTLNVGL 270 Query: 379 DNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAV-LTNDDDLLIL 432 + SW I H G + +AS ++GFT + L ND+ L L Sbjct: 271 ER---------SW-------CIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSL 309 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 65/275 (23%), Positives = 113/275 (41%), Gaps = 22/275 (8%) Query: 64 SSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDIS 123 S V + F P + ++ + SG+V +W + E S++V +E V AG Sbjct: 13 SDRVKGIDFHPTE--PWVLTTLYSGRVEIWNYETQVEVRSIQV---TETPVRAGK----- 62 Query: 124 WDFEGRRLCVVGEGRDNFGVFI-SWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDD 182 F R+ ++ G D+F + + ++++G + + H I + + ++P ++ DD Sbjct: 63 --FIARKNWII-VGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPY-VLSGSDD 118 Query: 183 GSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFD-GKSGEF 241 +V + A ++T FV V F+P + DR + + G+S Sbjct: 119 LTVKLWNWE--NNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPN 176 Query: 242 LKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQ 301 + QE + D T D TI++WD T CV TL+ + N Sbjct: 177 FT-LTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVA--TLEG-HMSNVS 232 Query: 302 VGVVATGNGRIISLSLDGTLNFYELGHDEVLKTIS 336 V IIS S DGTL + +V KT++ Sbjct: 233 FAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLN 267 >5L9T-R nrPDB Length = 493 Score = 39.3 bits (90), Expect = 0.005, Method: Compositional matrix adjust. Identities = 46/167 (27%), Positives = 74/167 (44%), Gaps = 32/167 (19%) Query: 455 SQNYVAVGLE------EGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSE--TYIAAG 506 S N ++VGL T QV +L DL V D S S+ SE +A G Sbjct: 197 SLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGD---------SVTSVGWSERGNLVAVG 247 Query: 507 DVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIF 566 G + ++D + + K S HT+++ A++W N E++ ++GS D I Sbjct: 248 THKGFVQIWDAAAGK-KLSMLEGHTARVGALAW-------NAEQL-----SSGSRDRMIL 294 Query: 567 IYSVKRP-MKIIKALNAHKDGVNNLLWETPSTLVSSGA-DACIKRWN 611 ++ P ++ + L H+ V L W T L++SG D + WN Sbjct: 295 QRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 341 >4V8M-A7 nrPDB Length = 318 Score = 39.3 bits (90), Expect = 0.005, Method: Compositional matrix adjust. Identities = 45/211 (21%), Positives = 95/211 (45%), Gaps = 26/211 (12%) Query: 154 GEVSGHSQRIN--ACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSAS------DRTHHKQ 205 G+++GH + AC + ++ D +++ + P + S+ DR Sbjct: 7 GQLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGH 66 Query: 206 GSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGE----FLKYIEDDQEPVQGGIFALSW 261 +FV DV S ++G F ++ D + ++ ++G+ FL + +D V F+ Sbjct: 67 SAFVSDVALS-NNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKD----VLSVAFSP-- 119 Query: 262 LDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGN---GRIISLSLD 318 D+++ + G D +RVW+V +C+ TL + + V + + I+S D Sbjct: 120 -DNRQIVSGGRDNALRVWNVK-GECMH--TLSRGAHTDWVSCVRFSPSLDAPVIVSGGWD 175 Query: 319 GTLNFYELGHDEVLKTISGHNKGITALTVNP 349 + ++L ++ + GH +T++TV+P Sbjct: 176 NLVKVWDLATGRLVTDLKGHTNYVTSVTVSP 206 >5MZH-A nrPDB Length = 452 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 31/120 (25%), Positives = 59/120 (49%), Gaps = 13/120 (10%) Query: 494 ISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEE 553 +S +P T IA G + L+D+++ + + + A H ++I ++ + Sbjct: 185 LSFNPQSTIIATGSMDNTAKLWDVETGQERAT-LAGHRAEIVSLGFNTGG---------- 233 Query: 554 DLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSGADACIKR-WNV 612 DL+ TGS D + ++ V R + + L+ H+ V++ + TLV SG+ C R W+V Sbjct: 234 DLIVTGSFDHDSRLWDV-RTGQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDV 292 Score = 37.7 bits (86), Expect = 0.015, Method: Compositional matrix adjust. Identities = 40/155 (25%), Positives = 66/155 (42%), Gaps = 21/155 (13%) Query: 218 SGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIR 277 SG+ IT DR ++ +GE + +E + V F + D K T D T + Sbjct: 105 SGDRFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFNNPYGD--KIVTGSFDKTCK 162 Query: 278 VWDVTTSKCVQKWTLDKQQLG------NQQVGVVATGNGRIISLSLDGTLNFYELGHDEV 331 +WD T + +TL Q N Q ++ATG S+D T +++ + Sbjct: 163 LWDAYTGQLY--YTLKGHQTEIVCLSFNPQSTIIATG-------SMDNTAKLWDVETGQE 213 Query: 332 LKTISGHNKGITALTVNP----LISGSYDGRIMEW 362 T++GH I +L N +++GS+D W Sbjct: 214 RATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLW 248 Score = 36.6 bits (83), Expect = 0.035, Method: Compositional matrix adjust. Identities = 34/149 (22%), Positives = 61/149 (40%), Gaps = 12/149 (8%) Query: 219 GEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRV 278 G+ ++T D +D ++G+ + + + V F + + D T R+ Sbjct: 233 GDLIVTGSFDHDSRLWDVRTGQCVHVLSGHRGEVSSTQFNYA---GTLVVSGSIDCTSRL 289 Query: 279 WDVTTSKCVQKWTLDKQQLGNQQVGVVATGNG-RIISLSLDGTLNFYELGHDEVLKTISG 337 WDV + +C+ KQ ++ + V G +++S S DG+ Y T+ G Sbjct: 290 WDVRSGRCLSV----KQGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLVG 345 Query: 338 HNKGITALTVNP----LISGSYDGRIMEW 362 H I+ + NP LI+ S D W Sbjct: 346 HEGEISKVAFNPQGTRLITASSDKTCRLW 374 Score = 34.7 bits (78), Expect = 0.13, Method: Compositional matrix adjust. Identities = 37/167 (22%), Positives = 70/167 (41%), Gaps = 20/167 (11%) Query: 209 VRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSW-LDSQKF 267 V + F+ G+ ++T D+ +D +G+ ++ Q I LS+ S Sbjct: 139 VYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTE----IVCLSFNPQSTII 194 Query: 268 ATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVA----TGNGRIISLSLDGTLNF 323 AT D T ++WDV T + ++ L + +V+ TG I++ S D Sbjct: 195 ATGSMDNTAKLWDVETGQ-------ERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRL 247 Query: 324 YELGHDEVLKTISGHNKGITALTVN----PLISGSYDGRIMEWSSSS 366 +++ + + +SGH +++ N ++SGS D W S Sbjct: 248 WDVRTGQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRS 294 Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 35/151 (23%), Positives = 60/151 (39%), Gaps = 10/151 (6%) Query: 218 SGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIR 277 +G V++ D +D +SG L + + V F + K + AD + R Sbjct: 274 AGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVAFDAA---GTKMVSASADGSAR 330 Query: 278 VWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISG 337 ++ T C + TL + +V G R+I+ S D T ++ E L+ + G Sbjct: 331 LYHTLTGVC--QHTLVGHEGEISKVAFNPQGT-RLITASSDKTCRLWDCDTGECLQVLEG 387 Query: 338 HNKGITALTVNP----LISGSYDGRIMEWSS 364 H I + N +I+GS D W + Sbjct: 388 HTDEIFSCAFNYEGDFIITGSKDNTCRIWKA 418 >4PSX-B nrPDB Length = 401 Score = 38.9 bits (89), Expect = 0.007, Method: Compositional matrix adjust. Identities = 17/61 (27%), Positives = 37/61 (60%), Gaps = 2/61 (3%) Query: 554 DLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWET--PSTLVSSGADACIKRWN 611 +L+A +D+ +++Y ++ + + ++ H+D VNNL + T +VSSG+D + W+ Sbjct: 265 NLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWD 324 Query: 612 V 612 + Sbjct: 325 L 325 >1VYH-C nrPDB Length = 410 Score = 38.5 bits (88), Expect = 0.008, Method: Compositional matrix adjust. Identities = 26/100 (26%), Positives = 47/100 (47%), Gaps = 7/100 (7%) Query: 267 FATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYEL 326 + DATI+VWD T + TL Q + +G + S S D T+ ++ Sbjct: 123 MVSASEDATIKVWDYETGDFER--TLKGHTDSVQDISFDHSGK-LLASCSADMTIKLWDF 179 Query: 327 GHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEW 362 E ++T+ GH+ ++++++ P ++S S D I W Sbjct: 180 QGFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMW 219 Score = 36.6 bits (83), Expect = 0.030, Method: Compositional matrix adjust. Identities = 47/225 (20%), Positives = 89/225 (39%), Gaps = 31/225 (13%) Query: 200 RTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFAL 259 RT H V V P+ G+ +++ D+ I ++ ++G +K +E V+ Sbjct: 186 RTMHGHDHNVSSVSIMPN-GDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVR---MVR 241 Query: 260 SWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLG-------------NQQVGVVA 306 D A+ D T+RVW V T +C + + + ++ G Sbjct: 242 PNQDGTLIASCSNDQTVRVWVVATKECKAELREHRHVVECISWAPESSYSSISEATGSET 301 Query: 307 TGNGR----IISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGR 358 +G+ ++S S D T+ +++ L T+ GH+ + + + ++S + D Sbjct: 302 KKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKT 361 Query: 359 IMEWSSSSMH-----QDHSNLIVSLDNSKAQEYSSI-SWDDTLKV 397 + W + H + + SLD K Y S D T+KV Sbjct: 362 LRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKV 406 Score = 30.0 bits (66), Expect = 3.1, Method: Compositional matrix adjust. Identities = 32/153 (20%), Positives = 66/153 (43%), Gaps = 11/153 (7%) Query: 199 DRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFA 258 +RT V+D+ F SG+ + + +D I +D + E ++ + V + Sbjct: 143 ERTLKGHTDSVQDISFD-HSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVS----S 197 Query: 259 LSWL-DSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRII-SLS 316 +S + + + D TI++W+V T CV+ +T ++ + V +G +I S S Sbjct: 198 VSIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRM----VRPNQDGTLIASCS 253 Query: 317 LDGTLNFYELGHDEVLKTISGHNKGITALTVNP 349 D T+ + + E + H + ++ P Sbjct: 254 NDQTVRVWVVATKECKAELREHRHVVECISWAP 286 >6BX3-A nrPDB Length = 314 Score = 38.1 bits (87), Expect = 0.011, Method: Compositional matrix adjust. Identities = 50/194 (25%), Positives = 80/194 (41%), Gaps = 34/194 (17%) Query: 219 GEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRV 278 G + T D I +D +G +K I E V ++ DS ++ D IR+ Sbjct: 107 GNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMN--DSSILSSGSYDGLIRI 164 Query: 279 WDVTTSKCVQKWTLDKQQLGNQQVGVVATG------NGRIISL-SLDGTLNFYELGHDEV 331 +D T C++ T DK ++ GVV N R + + SLDG + ++ V Sbjct: 165 FDAETGHCLKTLTYDKDW--KRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCV 222 Query: 332 LKT---------ISGHNKGITALTVNP-------LISGSYDGRIMEWSSSSMHQDHSNLI 375 ++T + H+ G+ L NP +ISG +G I W+S D +L+ Sbjct: 223 VRTFQVQPLEKGVLHHSCGMDFL--NPEDGSTPLVISGYENGDIYCWNS-----DTKSLL 275 Query: 376 VSLDNSKAQEYSSI 389 LD S S + Sbjct: 276 QLLDGSLYHHSSPV 289 Score = 29.6 bits (65), Expect = 3.8, Method: Compositional matrix adjust. Identities = 31/138 (22%), Positives = 54/138 (39%), Gaps = 18/138 (13%) Query: 481 FDLKTPLRA----KPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINA 536 F TP+ K + ISP ++A + IL+YD+ R V + H + Sbjct: 1 FQFVTPVGTQNGLKATCAKISPDGQFLAITQGL-NILIYDINRRTVSQTLVTSHARPFSE 59 Query: 537 ISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPS 596 + W P + +AT S D ++ I + ++ H V +L + Sbjct: 60 LCWSP----------DGQCIATASDDFSVEI--IHLSYGLLHTFIGHTAPVISLTFNRKG 107 Query: 597 TLV-SSGADACIKRWNVV 613 L+ +S D IK W+ + Sbjct: 108 NLLFTSSMDESIKIWDTL 125 >6J6H-n nrPDB Length = 455 Score = 38.1 bits (87), Expect = 0.012, Method: Compositional matrix adjust. Identities = 36/162 (22%), Positives = 66/162 (40%), Gaps = 20/162 (12%) Query: 212 VEFSPDSGEFVITVGSDRKISCFD-GKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATV 270 ++F P +G +++ G+D I +D E L+ + +P++ F D Q F + Sbjct: 168 LKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTE---DCQSFLSS 224 Query: 271 GADATIRVWDVTTSKCVQKWTLD------KQQLGNQQVGVVATGNGRIISLSLDGTLNFY 324 D ++++WD T K + L+ + + N +V N +I+ + N Sbjct: 225 SFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSEN-- 282 Query: 325 ELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEW 362 +++T H I AL P IS S D + W Sbjct: 283 ----QGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 Score = 30.8 bits (68), Expect = 1.6, Method: Compositional matrix adjust. Identities = 18/73 (24%), Positives = 31/73 (42%), Gaps = 8/73 (10%) Query: 52 KVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSE 111 K P F GH SS + + +Y+CSGD ++ W W + N++++ Sbjct: 370 KRHPKKIFKGH-SSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNK- 427 Query: 112 FQVLAGPISDISW 124 PI+ + W Sbjct: 428 ------PITQVDW 434 >5GAN-H nrPDB Length = 465 Score = 38.1 bits (87), Expect = 0.012, Method: Compositional matrix adjust. Identities = 41/167 (24%), Positives = 71/167 (42%), Gaps = 13/167 (7%) Query: 203 HKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWL 262 H +G F + F D G V + G D +D +SG + + +P I+ ++W Sbjct: 306 HDKGVF--SLSFQCD-GSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKP----IYTVAWS 358 Query: 263 -DSQKFATVGADATIRVWDVTTSKCVQ-KWTLDKQQLGNQQVGVVATGNGRIISLSLDGT 320 + + AT G D I VWD+ Q L + + Q G +++S D Sbjct: 359 PNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNL 418 Query: 321 LNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWS 363 +N Y + +++GH I +L ++ L+SG +D I W+ Sbjct: 419 INVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465 Score = 30.4 bits (67), Expect = 2.1, Method: Compositional matrix adjust. Identities = 35/126 (27%), Positives = 61/126 (48%), Gaps = 12/126 (9%) Query: 489 AKPSY-ISISPSETYIAAGDVMGKILLYDLQSR-EVKTSRWAFHTSKINAISWKPAEKGA 546 +KP Y ++ SP+ +A G G I ++D++ R E + ++ H + + + + + G Sbjct: 349 SKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDGG- 407 Query: 547 NEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNL-LWETPSTLVSSGADA 605 + LV+ G D I +YS +K+ +L H D + +L + LVS G D Sbjct: 408 ------KKLVSCG-YDNLINVYSSDTWLKM-GSLAGHTDKIISLDISNNSHFLVSGGWDR 459 Query: 606 CIKRWN 611 IK WN Sbjct: 460 SIKLWN 465 >5OPT-p nrPDB Length = 318 Score = 38.1 bits (87), Expect = 0.012, Method: Compositional matrix adjust. Identities = 46/211 (21%), Positives = 93/211 (44%), Gaps = 26/211 (12%) Query: 154 GEVSGH--------SQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQ 205 G++ GH +I ++K R T+ GS + ++ +R Sbjct: 7 GQLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGH 66 Query: 206 GSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSG----EFLKYIEDDQEPVQGGIFALSW 261 +FV DV S ++G+F ++ D + ++ ++G +FL + +D V F+ Sbjct: 67 SAFVSDVALS-NNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKD----VLSVTFSP-- 119 Query: 262 LDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGR---IISLSLD 318 D+++ + G D +RVW+V +C+ TL + + V + + I+S D Sbjct: 120 -DNRQIVSGGRDNALRVWNVK-GECLH--TLGRGAHTDWVSCVRFSPSLETPLIVSGGWD 175 Query: 319 GTLNFYELGHDEVLKTISGHNKGITALTVNP 349 + +++ +L + GH IT++TV+P Sbjct: 176 NLVKVWDIASGRLLTDLKGHTNYITSVTVSP 206 >6EMK-B nrPDB Length = 303 Score = 37.7 bits (86), Expect = 0.014, Method: Compositional matrix adjust. Identities = 66/314 (21%), Positives = 119/314 (37%), Gaps = 75/314 (23%) Query: 43 VRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESN 102 VR D + PV F GH +V T+V F + ++++ + E G + VW D S Sbjct: 55 VRLYDIRTTNPNPVASFEGHRGNV-TSVSFQ--QDNRWMVTSSEDGTIKVW----DVRSP 107 Query: 103 SVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDS-GNSLGEVSGHSQ 161 S+ N K P++++ V+ N G IS D GN G +Q Sbjct: 108 SIPRNYKHN-----APVNEV----------VI---HPNQGELISCDRDGNIRIWDLGENQ 149 Query: 162 RINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEF 221 + + ++S+++ DGS++ A+ T K +V ++ D+ Sbjct: 150 CTHQLTPEDDTSLQSLSMASDGSML----------AAANT--KGNCYVWEMPNHTDASHL 197 Query: 222 VITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDV 281 + ++ F S + + D + AT AD T RVW + Sbjct: 198 -------KPVTKFRAHSTYITRILLSS--------------DVKHLATCSADHTARVWSI 236 Query: 282 -------TTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKT 334 TT Q+W D + + +++ S D + ++L E+++ Sbjct: 237 DDDFKLETTLDGHQRWVWD---------CAFSADSAYLVTASSDHYVRLWDLSTREIVRQ 287 Query: 335 ISGHNKGITALTVN 348 GH+KG + +N Sbjct: 288 YGGHHKGAVCVALN 301 >5WLC-LO nrPDB Length = 923 Score = 37.0 bits (84), Expect = 0.023, Method: Compositional matrix adjust. Identities = 37/148 (25%), Positives = 65/148 (43%), Gaps = 17/148 (11%) Query: 263 DSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRII-SLSLDGTL 321 D + T D I+VWD+T+ C+ + ++ + V G+++ S SLDGT+ Sbjct: 356 DGSRVVTASEDGKIKVWDITSGFCLATF----EEHTSSVTAVQFAKRGQVMFSSSLDGTV 411 Query: 322 NFYELGHDEVLKTISGHNK-GITALTVNP----LISGSYDG-RIMEWSSSSMH-----QD 370 ++L +T +G + L V+P + +GS D I WS + Sbjct: 412 RAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSG 471 Query: 371 HSNLIVSLDNSKAQE-YSSISWDDTLKV 397 H + L S+ +S SWD T+++ Sbjct: 472 HEGPVSCLSFSQENSVLASASWDKTIRI 499 Score = 31.2 bits (69), Expect = 1.4, Method: Compositional matrix adjust. Identities = 40/149 (26%), Positives = 59/149 (39%), Gaps = 19/149 (12%) Query: 29 TTNAIAYPCGKSAFVRCLDDGDSKVPPVVQ------FTGHGSSVVTTVKFSPIKGSQYLC 82 +TN++AY S V +DG KV + F H SS VT V+F+ K Q + Sbjct: 347 STNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSS-VTAVQFA--KRGQVMF 403 Query: 83 SGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFG 142 S G V W + + + +F LA D G +C DNF Sbjct: 404 SSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAV-------DPSGEVVC--AGSLDNFD 454 Query: 143 VFI-SWDSGNSLGEVSGHSQRINACHLKQ 170 + + S +G L +SGH ++ Q Sbjct: 455 IHVWSVQTGQLLDALSGHEGPVSCLSFSQ 483 >5I2T-A nrPDB Length = 742 Score = 37.0 bits (84), Expect = 0.024, Method: Compositional matrix adjust. Identities = 37/148 (25%), Positives = 65/148 (43%), Gaps = 17/148 (11%) Query: 263 DSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRII-SLSLDGTL 321 D + T D I+VWD+T+ C+ + ++ + V G+++ S SLDGT+ Sbjct: 381 DGSRVVTASEDGKIKVWDITSGFCLATF----EEHTSSVTAVQFAKRGQVMFSSSLDGTV 436 Query: 322 NFYELGHDEVLKTISGHNK-GITALTVNP----LISGSYDG-RIMEWSSSSMH-----QD 370 ++L +T +G + L V+P + +GS D I WS + Sbjct: 437 RAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSG 496 Query: 371 HSNLIVSLDNSKAQE-YSSISWDDTLKV 397 H + L S+ +S SWD T+++ Sbjct: 497 HEGPVSCLSFSQENSVLASASWDKTIRI 524 Score = 30.4 bits (67), Expect = 2.5, Method: Compositional matrix adjust. Identities = 40/149 (26%), Positives = 59/149 (39%), Gaps = 19/149 (12%) Query: 29 TTNAIAYPCGKSAFVRCLDDGDSKVPPVVQ------FTGHGSSVVTTVKFSPIKGSQYLC 82 +TN++AY S V +DG KV + F H SS VT V+F+ K Q + Sbjct: 372 STNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSS-VTAVQFA--KRGQVMF 428 Query: 83 SGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFG 142 S G V W + + + +F LA D G +C DNF Sbjct: 429 SSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAV-------DPSGEVVC--AGSLDNFD 479 Query: 143 VFI-SWDSGNSLGEVSGHSQRINACHLKQ 170 + + S +G L +SGH ++ Q Sbjct: 480 IHVWSVQTGQLLDALSGHEGPVSCLSFSQ 508 >6QDV-o nrPDB Length = 513 Score = 37.0 bits (84), Expect = 0.027, Method: Compositional matrix adjust. Identities = 63/306 (20%), Positives = 125/306 (40%), Gaps = 41/306 (13%) Query: 336 SGHNKGITALTVNP-----LISGSYDGRIMEWSSSSMHQ------DHSNLIVSLD-NSKA 383 SGH KG++A+ + P L+S S D +I W + HS + + N+ Sbjct: 219 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAG 278 Query: 384 QEYSSISWDDTLKV------NGITKHEFGSQPKVASANNDG-----FTAVLTNDDDLLIL 432 ++ S ++D LK+ I++ P N D F A ++ D ++ Sbjct: 279 TQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMS-DKKIVQW 337 Query: 433 QSFTGDIIKSV--RLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFD-LKTPLRA 489 +G+I++ L + + V + +N V + +++V++ D+ V F + P Sbjct: 338 DIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEW-DIPVDFKYIAEPSMH 396 Query: 490 KPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEE 549 +++SP+ ++A + +IL++ Q+R F +K A + Sbjct: 397 SMPAVTLSPNGKWLACQSMDNQILIFGAQNR--------FRLNKKKIFKGHMVAGYACQV 448 Query: 550 EIEEDL--VATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPST--LVSSGADA 605 + D+ V +G + + I+ K K+ AH +W T +++ G D Sbjct: 449 DFSPDMSYVISGDGNGKLNIWDWKT-TKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDG 507 Query: 606 CIKRWN 611 IK W+ Sbjct: 508 LIKLWD 513 >6BX3-B nrPDB Length = 412 Score = 36.6 bits (83), Expect = 0.035, Method: Compositional matrix adjust. Identities = 27/113 (23%), Positives = 52/113 (46%), Gaps = 15/113 (13%) Query: 471 VFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSRE---VKTSRW 527 V K +++ ++ PLR + + SP Y+A G G +++YD+ + V + Sbjct: 10 VLKEHPEKLTHTIENPLRTE--CLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNML 67 Query: 528 AFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKAL 580 H I +I+W P + L+ T S D +I ++ + +P K +K + Sbjct: 68 GAHVRPITSIAWSPDGR----------LLLTSSRDWSIKLWDLSKPSKPLKEI 110 >5NZU-C nrPDB Length = 905 Score = 36.6 bits (83), Expect = 0.035, Method: Compositional matrix adjust. Identities = 37/153 (24%), Positives = 66/153 (43%), Gaps = 20/153 (13%) Query: 221 FVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKF-ATVGADATIRVW 279 +V+T D +I F+ + E + E + ++ ++ +Q F T D I++W Sbjct: 71 WVVTGADDMQIRVFNYNTLERVHMFEAHSDYIR----CIAVHPTQPFILTSSDDMLIKLW 126 Query: 280 DVTTSKCVQKWTLDKQQLGN----QQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTI 335 D +KW+ + G+ Q+ + N + S SLD T+ ++LG T+ Sbjct: 127 DWD-----KKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTL 181 Query: 336 SGHNKGITALTVNP------LISGSYDGRIMEW 362 GH KG+ + LISG+ D + W Sbjct: 182 EGHEKGVNCIDYYSGGDKPYLISGADDRLVKIW 214 >5OQL-L nrPDB Length = 557 Score = 36.6 bits (83), Expect = 0.036, Method: Compositional matrix adjust. Identities = 40/175 (22%), Positives = 75/175 (42%), Gaps = 24/175 (13%) Query: 203 HKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWL 262 HKQ +V ++SP +++ D+ + +D S + + + V+ G F Sbjct: 143 HKQPVWV--TKWSPTELTTLMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSA 200 Query: 263 DSQKFATVGADATIRVWD-------VTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISL 315 +S + D T+RVWD V T K D L + + A+GN Sbjct: 201 NSNLLVSGSYDETVRVWDARAPGGAVMTFKHADPIE-DVLPLPSGTTLLAASGNA----- 254 Query: 316 SLDGTLNFYELGHDEVLKTISGHNKGITALTV----NPLISGSYDGRIMEWSSSS 366 ++ +L + L+ I+ H K +T+L++ ++SGS DG + + ++S Sbjct: 255 -----ISVLDLVAAKPLRLITNHQKTVTSLSLASQGRRVVSGSLDGHVKVFETTS 304 >5WYK-BB nrPDB Length = 943 Score = 36.2 bits (82), Expect = 0.039, Method: Compositional matrix adjust. Identities = 31/124 (25%), Positives = 56/124 (45%), Gaps = 7/124 (5%) Query: 209 VRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFA 268 V ++ S DS + +IT +D+ I + G+ K + Q+ + F S F Sbjct: 576 VLSIDISFDS-KMIITSSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQ---SHNFF 631 Query: 269 TVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGH 328 + DA ++ WD +C+QK + ++ VAT G ++S S D ++ +E Sbjct: 632 SCSKDAVVKYWDGEKFECIQKLYAHQSEV---WALAVATDGGFVVSSSHDHSIRIWEETE 688 Query: 329 DEVL 332 D+V Sbjct: 689 DQVF 692 Score = 36.2 bits (82), Expect = 0.049, Method: Compositional matrix adjust. Identities = 23/105 (21%), Positives = 47/105 (44%), Gaps = 10/105 (9%) Query: 263 DSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLN 322 D K ++ ++++W++ T KC++ + + G G +I + +G L Sbjct: 401 DDNKLLATASNGSLKIWNIKTHKCIRTF-----ECGYALTCKFLPGGLLVILGTRNGELQ 455 Query: 323 FYELGHDEVLKTIS-GHNKGITALTVNP----LISGSYDGRIMEW 362 ++L +L TI H+ I +L + L++GS D + W Sbjct: 456 LFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFW 500 Score = 33.5 bits (75), Expect = 0.29, Method: Compositional matrix adjust. Identities = 30/124 (24%), Positives = 56/124 (45%), Gaps = 12/124 (9%) Query: 489 AKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANE 548 A+ +Y+ +A G G I ++DL S+ V + + H + I + + G Sbjct: 80 AECTYLEAHKDTDLLAVGYADGVIKVWDLMSKTVLLN-FNGHKAAITLLQFD----GTGT 134 Query: 549 EEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSGADACIK 608 I +GS D+NI ++ + + + K L +HKD + + L+S+ D IK Sbjct: 135 RLI------SGSKDSNIIVWDLVGEVGLYK-LRSHKDSITGFWCQGEDWLISTSKDGMIK 187 Query: 609 RWNV 612 W++ Sbjct: 188 LWDL 191 Score = 31.2 bits (69), Expect = 1.3, Method: Compositional matrix adjust. Identities = 19/49 (38%), Positives = 24/49 (48%), Gaps = 4/49 (8%) Query: 318 DGTLNFYELGHDEVLKTISGHNKGITAL----TVNPLISGSYDGRIMEW 362 DG + ++L VL +GH IT L T LISGS D I+ W Sbjct: 100 DGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVW 148 >5YZG-W nrPDB Length = 579 Score = 35.8 bits (81), Expect = 0.050, Method: Compositional matrix adjust. Identities = 63/306 (20%), Positives = 125/306 (40%), Gaps = 41/306 (13%) Query: 336 SGHNKGITALTVNP-----LISGSYDGRIMEWSSSSMHQ------DHSNLIVSLD-NSKA 383 SGH KG++A+ + P L+S S D +I W + HS + + N+ Sbjct: 285 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAG 344 Query: 384 QEYSSISWDDTLKV------NGITKHEFGSQPKVASANNDG-----FTAVLTNDDDLLIL 432 ++ S ++D LK+ I++ P N D F A ++ D ++ Sbjct: 345 TQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMS-DKKIVQW 403 Query: 433 QSFTGDIIKSV--RLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFD-LKTPLRA 489 +G+I++ L + + V + +N V + +++V++ D+ V F + P Sbjct: 404 DIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEW-DIPVDFKYIAEPSMH 462 Query: 490 KPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEE 549 +++SP+ ++A + +IL++ Q+R F +K A + Sbjct: 463 SMPAVTLSPNGKWLACQSMDNQILIFGAQNR--------FRLNKKKIFKGHMVAGYACQV 514 Query: 550 EIEEDL--VATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPST--LVSSGADA 605 + D+ V +G + + I+ K K+ AH +W T +++ G D Sbjct: 515 DFSPDMSYVISGDGNGKLNIWDWKT-TKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDG 573 Query: 606 CIKRWN 611 IK W+ Sbjct: 574 LIKLWD 579 >4U1E-I nrPDB Length = 347 Score = 35.8 bits (81), Expect = 0.062, Method: Compositional matrix adjust. Identities = 34/127 (26%), Positives = 58/127 (45%), Gaps = 27/127 (21%) Query: 266 KFATVG-ADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISL----SLDGT 320 K+ G AD +I++WDV+ +CV W K + ++V GN + L G+ Sbjct: 65 KYCVTGSADYSIKLWDVSNGQCVATW---KSPVPVKRVEFSPCGNYFLAILDNVMKNPGS 121 Query: 321 LNFYELGHD-----------EVLKTISGHNKGITALTV-------NPLISGSYDGRIMEW 362 +N YE+ D E + I H +G+ A TV +I+G DG+I ++ Sbjct: 122 INIYEIERDSATHELTKVSEEPIHKIITH-EGLDAATVAGWSTKGKYIIAGHKDGKISKY 180 Query: 363 SSSSMHQ 369 S+ ++ Sbjct: 181 DVSNNYE 187 >5UZ7-B nrPDB Length = 351 Score = 35.4 bits (80), Expect = 0.070, Method: Compositional matrix adjust. Identities = 39/159 (24%), Positives = 69/159 (43%), Gaps = 20/159 (12%) Query: 254 GGIFALSWL-DSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRI 312 G + +LS D++ F + DA+ ++WDV C Q +T + + + GN Sbjct: 196 GDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDI--NAICFFPNGNA-F 252 Query: 313 ISLSLDGTLNFYELGHDEVLKTISGHN--KGITALTVNP----LISGSYDGRIMEWSSSS 366 + S D T ++L D+ L T S N GIT+++ + L++G D W + Sbjct: 253 ATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW--DA 310 Query: 367 MHQDHSNLIVSLDN--------SKAQEYSSISWDDTLKV 397 + D + ++ DN ++ SWD LK+ Sbjct: 311 LKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKI 349 Score = 33.9 bits (76), Expect = 0.20, Method: Compositional matrix adjust. Identities = 48/234 (20%), Positives = 92/234 (39%), Gaps = 22/234 (9%) Query: 156 VSGHSQRINACHL-KQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHH--KQGSFVRDV 212 + GH +I A H SR + ++ DG ++ + +++ H + S+V Sbjct: 62 LRGHLAKIYAMHWGTDSRLL--VSASQDGKLIIWDSYT-----TNKVHAIPLRSSWVMTC 114 Query: 213 EFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGA 272 ++P SG +V G D S ++ K+ E + + G + +LD + T Sbjct: 115 AYAP-SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG 173 Query: 273 DATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVL 332 D T +WD+ T + G+ +A +S + D + +++ Sbjct: 174 DTTCALWDIETGQQTTT---FTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR 230 Query: 333 KTISGHNKGITALTV----NPLISGSYDG--RIMEWSSSS--MHQDHSNLIVSL 378 +T +GH I A+ N +GS D R+ + + M H N+I + Sbjct: 231 QTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGI 284 Score = 31.6 bits (70), Expect = 1.1, Method: Compositional matrix adjust. Identities = 31/131 (23%), Positives = 57/131 (43%), Gaps = 15/131 (11%) Query: 486 PLRAK-PSYISISPSETYIAAGDVMGKILLYDLQSRE--VKTSR-WAFHTSKINAISWKP 541 PLR+ + +PS Y+A G + +Y+L++RE V+ SR A HT ++ + Sbjct: 105 PLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-- 162 Query: 542 AEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSS 601 ++++ + T S DT ++ ++ + D ++ L VS Sbjct: 163 ---------LDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSG 213 Query: 602 GADACIKRWNV 612 DA K W+V Sbjct: 214 ACDASAKLWDV 224 >4N14-A nrPDB Length = 314 Score = 35.4 bits (80), Expect = 0.079, Method: Compositional matrix adjust. Identities = 25/121 (20%), Positives = 55/121 (45%), Gaps = 9/121 (7%) Query: 426 DDDLLILQSFTGDIIKSVRLNSPGSAVS-----LSQNYVAVGLEEGNTIQVFKLSDLEVS 480 D+ + + + +GDI++ +++ PG +S NY+AVG +L D++ Sbjct: 40 DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEV----QLWDVQQQ 95 Query: 481 FDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWK 540 L+ S+S + +++G G I +D++ E + + H+ ++ + W Sbjct: 96 KRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWA 155 Query: 541 P 541 P Sbjct: 156 P 156 >5WJC-A nrPDB Length = 430 Score = 35.4 bits (80), Expect = 0.080, Method: Compositional matrix adjust. Identities = 22/85 (25%), Positives = 38/85 (44%), Gaps = 11/85 (12%) Query: 530 HTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNN 589 H+ INA++ P + L+AT S D + ++ ++ P + + L H+D V Sbjct: 280 HSKAINAVAINP---------FNDYLLATASADKTVALWDLRNPYQRLHTLEGHEDEVYG 330 Query: 590 LLW--ETPSTLVSSGADACIKRWNV 612 L W L SS D + W++ Sbjct: 331 LEWSPHDEPILASSSTDRRVCIWDL 355 Score = 34.7 bits (78), Expect = 0.14, Method: Compositional matrix adjust. Identities = 45/190 (23%), Positives = 67/190 (35%), Gaps = 36/190 (18%) Query: 209 VRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGI----FALSWLDS 264 V + P E + T+G FD + L E + V G F L W + Sbjct: 134 VNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLCWNPN 193 Query: 265 Q--KFATVGADATIRVWDVTTSKCVQKWT---------------LDKQQLGNQQVGVVAT 307 AT D I +WDV T T ++ Q Q ++A Sbjct: 194 LPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEALLA- 252 Query: 308 GNGRIISLSLDGTLNFYEL---GHDEVLKTISGHNKGITALTVNP-----LISGSYDGRI 359 S+S D TL ++ +E K I H+K I A+ +NP L + S D + Sbjct: 253 ------SVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTV 306 Query: 360 MEWSSSSMHQ 369 W + +Q Sbjct: 307 ALWDLRNPYQ 316 Score = 33.1 bits (74), Expect = 0.41, Method: Compositional matrix adjust. Identities = 20/83 (24%), Positives = 36/83 (43%), Gaps = 5/83 (6%) Query: 202 HHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGK---SGEFLKYIEDDQEPVQGGIFA 258 +H+ V DV+F P + +V D + D + E K I+ + + A Sbjct: 231 YHRHTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINA--VA 288 Query: 259 LSWLDSQKFATVGADATIRVWDV 281 ++ + AT AD T+ +WD+ Sbjct: 289 INPFNDYLLATASADKTVALWDL 311 >5WLC-LU nrPDB Length = 489 Score = 35.4 bits (80), Expect = 0.081, Method: Compositional matrix adjust. Identities = 69/281 (24%), Positives = 121/281 (43%), Gaps = 62/281 (22%) Query: 337 GHNKGITAL-----TVNPLISGSYDGRIMEWSSSSMHQ-----DHSNLIVSL-------- 378 GH G+ A+ ++N L +GS DG I W+ S+ + H L+ L Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPRFH 124 Query: 379 ---DNSKAQEYS-SISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQS 434 + K+Q + S S D T+K+ I ++ ++ S++ND +TN++ L +++ Sbjct: 125 DKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNK---NSSDNDS----VTNEEGL--IRT 175 Query: 435 FTGDI----IKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAK 490 F G+ I S R NS + + + L + N ++ +SDL D T L+ Sbjct: 176 FDGESAFQGIDSHRENS-----TFATGGAKIHLWDVNRLK--PVSDLSWGADNITSLKFN 228 Query: 491 PSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEE 550 + I +A+ I+LYDL R ++ T + NAI W P E Sbjct: 229 QNETDI------LASTGSDNSIVLYDL--RTNSPTQKIVQTMRTNAICWNPMEAFN---- 276 Query: 551 IEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLL 591 T + D N + Y ++ + ++LN KD V+ ++ Sbjct: 277 -----FVTANEDHNAYYYDMR---NLSRSLNVFKDHVSAVM 309 >4GGA-A nrPDB Length = 420 Score = 35.0 bits (79), Expect = 0.11, Method: Compositional matrix adjust. Identities = 25/121 (20%), Positives = 55/121 (45%), Gaps = 9/121 (7%) Query: 426 DDDLLILQSFTGDIIKSVRLNSPGSAVS-----LSQNYVAVGLEEGNTIQVFKLSDLEVS 480 D+ + + + +GDI++ +++ PG +S NY+AVG +L D++ Sbjct: 124 DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAE----VQLWDVQQQ 179 Query: 481 FDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWK 540 L+ S+S + +++G G I +D++ E + + H+ ++ + W Sbjct: 180 KRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWA 239 Query: 541 P 541 P Sbjct: 240 P 240 >5LCW-Q nrPDB Length = 374 Score = 34.7 bits (78), Expect = 0.11, Method: Compositional matrix adjust. Identities = 25/121 (20%), Positives = 55/121 (45%), Gaps = 9/121 (7%) Query: 426 DDDLLILQSFTGDIIKSVRLNSPGSAVS-----LSQNYVAVGLEEGNTIQVFKLSDLEVS 480 D+ + + + +GDI++ +++ PG +S NY+AVG +L D++ Sbjct: 78 DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAE----VQLWDVQQQ 133 Query: 481 FDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWK 540 L+ S+S + +++G G I +D++ E + + H+ ++ + W Sbjct: 134 KRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWA 193 Query: 541 P 541 P Sbjct: 194 P 194 >4BZK-B nrPDB Length = 297 Score = 34.7 bits (78), Expect = 0.13, Method: Compositional matrix adjust. Identities = 39/179 (21%), Positives = 74/179 (41%), Gaps = 23/179 (12%) Query: 119 ISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHS---QRINACHLKQSRPMR 175 I D D+ G+RL + + ++ + ++GH R++ H K + Sbjct: 12 IHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILA 71 Query: 176 SMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSP-DSGEFVITVGSDRKISCF 234 S + DG V+ ++ ++S H + V V+++P + G ++ SD K+S Sbjct: 72 SCSY--DGKVLIWKEENGRWSQI-AVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVV 128 Query: 235 DGKSGEFLKYIEDDQEPVQGGIFALSWL--------------DSQKFATVGADATIRVW 279 + K I D + G+ + SW +S+KF T GAD +++W Sbjct: 129 EFKENGTTSPIIIDAHAI--GVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 185 Score = 32.7 bits (73), Expect = 0.47, Method: Compositional matrix adjust. Identities = 33/131 (25%), Positives = 57/131 (43%), Gaps = 34/131 (25%) Query: 501 TYIAAGDVMGKILLYDLQS-REVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATG 559 T +A+ GK+L++ ++ R + + A H++ +N++ W P E G L+ Sbjct: 68 TILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGP--------LLLVA 119 Query: 560 SLDTNIFIYSVKR-----PMKIIKALNAHKDGVNNLLWETPSTL---------------V 599 S D + + K P+ I +AH GVN+ W P+T+ V Sbjct: 120 SSDGKVSVVEFKENGTTSPIII----DAHAIGVNSASW-APATIEEDGEHNGTKESRKFV 174 Query: 600 SSGADACIKRW 610 + GAD +K W Sbjct: 175 TGGADNLVKIW 185 >4BH6-A nrPDB Length = 308 Score = 34.7 bits (78), Expect = 0.13, Method: Compositional matrix adjust. Identities = 32/154 (20%), Positives = 63/154 (40%), Gaps = 26/154 (16%) Query: 451 AVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMG 510 AV+L + ++ L + NT V L D E + + +S + +++A G G Sbjct: 38 AVALGK---SIFLTDNNTGDVVHLCDTENEY----------TSLSWIGAGSHLAVGQANG 84 Query: 511 KILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSV 570 + +YD+ R+ + + H ++ +SW ++ +GS D I V Sbjct: 85 LVEIYDVMKRKCIRTL-SGHIDRVACLSW------------NNHVLTSGSRDHRILHRDV 131 Query: 571 KRPMKIIKALNAHKDGVNNLLWETPSTLVSSGAD 604 + P + + +H V L W ++SG + Sbjct: 132 RMPDPFFETIESHTQEVCGLKWNVADNKLASGGN 165 >3ODT-A nrPDB Length = 313 Score = 34.7 bits (78), Expect = 0.13, Method: Compositional matrix adjust. Identities = 28/103 (27%), Positives = 48/103 (46%), Gaps = 10/103 (9%) Query: 265 QKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVAT-GNGRIISLSLDGTLNF 323 KF T AD TI++W K ++ ++ + N V +A +G IS S DG + Sbjct: 156 NKFLTASADKTIKLWQ--NDKVIKTFS----GIHNDVVRHLAVVDDGHFISCSNDGLIKL 209 Query: 324 YELGHDEVLKTISGHNKGITALTVNP---LISGSYDGRIMEWS 363 ++ +VL+T GH + + + P ++S D + WS Sbjct: 210 VDMHTGDVLRTYEGHESFVYCIKLLPNGDIVSCGEDRTVRIWS 252 Score = 33.9 bits (76), Expect = 0.22, Method: Compositional matrix adjust. Identities = 65/292 (22%), Positives = 116/292 (39%), Gaps = 51/292 (17%) Query: 266 KFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYE 325 K A+V D T+R+ W+ D Q LG VV TG G + S+ D Sbjct: 31 KVASVSRDGTVRL-----------WSKDDQWLGT----VVYTGQGFLNSVCYDSEKELLL 75 Query: 326 LGHDEV---------------LKTISGHNKGITALTVNP--LISGSYDGRIMEWSSSSMH 368 G + L T+ GH + +L+ +ISGS+D W S+ Sbjct: 76 FGGKDTMINGVPLFATSGEDPLYTLIGHQGNVCSLSFQDGVVISGSWDKTAKVWKEGSLV 135 Query: 369 QDHSNLIVSLDNSKAQEYS-----SISWDDTLKV---NGITKHEFGSQPKVA---SANND 417 + S+ ++K +S + S D T+K+ + + K G V + +D Sbjct: 136 YNLQAHNASVWDAKVVSFSENKFLTASADKTIKLWQNDKVIKTFSGIHNDVVRHLAVVDD 195 Query: 418 GFTAVLTNDDDLLILQSFTGDIIKSVRLN-SPGSAVSLSQNYVAVGLEEGNTIQVFKLSD 476 G +ND + ++ TGD++++ + S + L N V E T++++ + Sbjct: 196 GHFISCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGDIVSCGEDRTVRIWSKEN 255 Query: 477 LEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWA 528 + + P + S +S + + + D + +I S+E SRWA Sbjct: 256 GSLKQVITLPAISIWSVDCMSNGDIIVGSSDNLVRIF-----SQE--KSRWA 300 Score = 29.3 bits (64), Expect = 5.7, Method: Compositional matrix adjust. Identities = 24/95 (25%), Positives = 40/95 (42%), Gaps = 13/95 (13%) Query: 217 DSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATI 276 D G F I+ +D I D +G+ L+ E + V + + L + + G D T+ Sbjct: 194 DDGHF-ISCSNDGLIKLVDMHTGDVLRTYEGHESFV----YCIKLLPNGDIVSCGEDRTV 248 Query: 277 RVW--------DVTTSKCVQKWTLDKQQLGNQQVG 303 R+W V T + W++D G+ VG Sbjct: 249 RIWSKENGSLKQVITLPAISIWSVDCMSNGDIIVG 283 >3JRP-A nrPDB Length = 379 Score = 34.3 bits (77), Expect = 0.16, Method: Compositional matrix adjust. Identities = 39/179 (21%), Positives = 74/179 (41%), Gaps = 23/179 (12%) Query: 119 ISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHS---QRINACHLKQSRPMR 175 I D D+ G+RL + + ++ + ++GH R++ H K + Sbjct: 14 IHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILA 73 Query: 176 SMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSP-DSGEFVITVGSDRKISCF 234 S + DG V+ ++ ++S H + V V+++P + G ++ SD K+S Sbjct: 74 SCSY--DGKVLIWKEENGRWSQI-AVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVV 130 Query: 235 DGKSGEFLKYIEDDQEPVQGGIFALSWL--------------DSQKFATVGADATIRVW 279 + K I D + G+ + SW +S+KF T GAD +++W Sbjct: 131 EFKENGTTSPIIIDAHAI--GVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 187 Score = 33.1 bits (74), Expect = 0.35, Method: Compositional matrix adjust. Identities = 33/131 (25%), Positives = 57/131 (43%), Gaps = 34/131 (25%) Query: 501 TYIAAGDVMGKILLYDLQS-REVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATG 559 T +A+ GK+L++ ++ R + + A H++ +N++ W P E G L+ Sbjct: 70 TILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGP--------LLLVA 121 Query: 560 SLDTNIFIYSVKR-----PMKIIKALNAHKDGVNNLLWETPSTL---------------V 599 S D + + K P+ I +AH GVN+ W P+T+ V Sbjct: 122 SSDGKVSVVEFKENGTTSPIII----DAHAIGVNSASW-APATIEEDGEHNGTKESRKFV 176 Query: 600 SSGADACIKRW 610 + GAD +K W Sbjct: 177 TGGADNLVKIW 187 >3FM0-A nrPDB Length = 345 Score = 34.3 bits (77), Expect = 0.18, Method: Compositional matrix adjust. Identities = 20/113 (17%), Positives = 52/113 (46%), Gaps = 13/113 (11%) Query: 494 ISISPSETYIAAGDVMGKILLYDLQSREVKT-SRWAFHTSKINAISWKPAEKGANEEEIE 552 ++ SP Y+A+ ++ + + + H +++ +++W P+ Sbjct: 67 VAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSG--------- 117 Query: 553 EDLVATGSLDTNIFIYSVKRP--MKIIKALNAHKDGVNNLLWETPSTLVSSGA 603 +L+AT S D +++++ V + + LN+H V +++W L++S + Sbjct: 118 -NLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASAS 169 >4BTS-AR nrPDB Length = 343 Score = 34.3 bits (77), Expect = 0.18, Method: Compositional matrix adjust. Identities = 49/202 (24%), Positives = 82/202 (40%), Gaps = 35/202 (17%) Query: 350 LISGSYDGRIMEWSSSSMHQD------------HSNLIVSLDNSKAQEYS-SISWDDTLK 396 LISGS D +M W Q+ H++ + L S+ ++ S SWD TL+ Sbjct: 42 LISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLALSQENCFAISSSWDKTLR 101 Query: 397 V----NGITKHEF-GSQPKVASA--NNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPG 449 + G T F G Q +V S + D + + + L + G+ S Sbjct: 102 LWDLRTGTTYKRFVGHQSEVYSVAFSPDNRQILSAGAEREIKLWNILGECKFSSAEKENH 161 Query: 450 SAVSLSQNYVAVGLEEGNTIQVF-----------KLSDLEVSFDLKTPLRAKPS---YIS 495 S Y + ++ N +Q F +L +F ++ +A S ++S Sbjct: 162 SDWVSCVRYSPI-MKSANKVQPFAPYFASVGWDGRLKVWNTNFQIRYTFKAHESNVNHLS 220 Query: 496 ISPSETYIAAGDVMGKILLYDL 517 ISP+ YIA G K+L++D+ Sbjct: 221 ISPNGKYIATGGKDKKLLIWDI 242 >3JAP-g nrPDB Length = 326 Score = 33.9 bits (76), Expect = 0.19, Method: Compositional matrix adjust. Identities = 47/226 (20%), Positives = 91/226 (40%), Gaps = 22/226 (9%) Query: 154 GEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQ--GPPFKFSASDRTHHKQGSFVRD 211 G + GH+ + + ++P ++ D +++ ++ +F R++ V+D Sbjct: 12 GTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQD 71 Query: 212 VEFSPDSGEFVITVGSDRKISCFDGKSGEF-LKYIEDDQEPVQGGIFALSWLDSQKFATV 270 V S D G + ++ D+ + ++ +G +++ + + I A +S K + Sbjct: 72 VVVSAD-GNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDA----NSSKIISA 126 Query: 271 GADATIRVWDVTTSKCV------QKW-TLDKQQLGNQQVGVVATGNGRIISLSLDGTLNF 323 D TIRVW+ T C W T + N + G V G +S +D + Sbjct: 127 SRDKTIRVWN-TVGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRS 185 Query: 324 YELGHD--EVLKTISGHNKGITALTVNP----LISGSYDGRIMEWS 363 + L D + GHN I + +P S DG+I W+ Sbjct: 186 WSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWN 231 >5G04-R nrPDB Length = 499 Score = 33.9 bits (76), Expect = 0.21, Method: Compositional matrix adjust. Identities = 25/121 (20%), Positives = 55/121 (45%), Gaps = 9/121 (7%) Query: 426 DDDLLILQSFTGDIIKSVRLNSPGSAVS-----LSQNYVAVGLEEGNTIQVFKLSDLEVS 480 D+ + + + +GDI++ +++ PG +S NY+AVG +L D++ Sbjct: 203 DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAE----VQLWDVQQQ 258 Query: 481 FDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWK 540 L+ S+S + +++G G I +D++ E + + H+ ++ + W Sbjct: 259 KRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWA 318 Query: 541 P 541 P Sbjct: 319 P 319 >5A31-R nrPDB Length = 386 Score = 33.9 bits (76), Expect = 0.24, Method: Compositional matrix adjust. Identities = 32/154 (20%), Positives = 63/154 (40%), Gaps = 26/154 (16%) Query: 451 AVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMG 510 AV+L + ++ L + NT V L D E + + +S + +++A G G Sbjct: 107 AVALGK---SIFLTDNNTGDVVHLCDTENEY----------TSLSWIGAGSHLAVGQANG 153 Query: 511 KILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSV 570 + +YD+ R+ + + H ++ +SW ++ +GS D I V Sbjct: 154 LVEIYDVMKRKCIRTL-SGHIDRVACLSW------------NNHVLTSGSRDHRILHRDV 200 Query: 571 KRPMKIIKALNAHKDGVNNLLWETPSTLVSSGAD 604 + P + + +H V L W ++SG + Sbjct: 201 RMPDPFFETIESHTQEVCGLKWNVADNKLASGGN 234 >5WLC-LN nrPDB Length = 776 Score = 33.5 bits (75), Expect = 0.25, Method: Compositional matrix adjust. Identities = 37/180 (20%), Positives = 68/180 (37%), Gaps = 33/180 (18%) Query: 220 EFVITVGSDRKIS--CFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIR 277 E VI G DR I C+ +GE L+ ++G + Sbjct: 88 EMVIEGGKDRSIEGLCWSNVNGESLRLF-----------------------SIGGSTVVT 124 Query: 278 VWDVTTSKCVQKWTLDKQQL------GNQQVGVVATGNGRIISLSLDGTLNFYELGHDEV 331 WD+ T ++ + + + +Q V NG ++ + + G E HD + Sbjct: 125 EWDLATGLPLRNYDCNSGVIWSISINDSQDKLSVGCDNGTVVLIDISGGPGVLE--HDTI 182 Query: 332 LKTISGHNKGITALTVNPLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISW 391 L + + +I G DGRI WS+ ++ L+ ++ KA++ S++ W Sbjct: 183 LMRQEARVLTLAWKKDDFVIGGCSDGRIRIWSAQKNDENMGRLLHTMKVDKAKKESTLVW 242 >4AEZ-A nrPDB Length = 401 Score = 33.5 bits (75), Expect = 0.29, Method: Compositional matrix adjust. Identities = 36/157 (22%), Positives = 64/157 (40%), Gaps = 16/157 (10%) Query: 457 NYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYD 516 N VAV LE + V+ VS +T + + S ++++ G G + +YD Sbjct: 105 NVVAVALER--NVYVWNADSGSVSALAETDESTYVASVKWSHDGSFLSVGLGNGLVDIYD 162 Query: 517 LQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKI 576 ++S + K A H +++ +SW ++++GS I + V+ Sbjct: 163 VES-QTKLRTMAGHQARVGCLSW------------NRHVLSSGSRSGAIHHHDVRIANHQ 209 Query: 577 IKALNAHKDGVNNLLWETPS-TLVSSGADACIKRWNV 612 I L H V L W + L S G D ++ W+ Sbjct: 210 IGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDA 246 >3JRO-A nrPDB Length = 753 Score = 33.5 bits (75), Expect = 0.30, Method: Compositional matrix adjust. Identities = 39/179 (21%), Positives = 74/179 (41%), Gaps = 23/179 (12%) Query: 119 ISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHS---QRINACHLKQSRPMR 175 I D D+ G+RL + + ++ + ++GH R++ H K + Sbjct: 12 IHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILA 71 Query: 176 SMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSP-DSGEFVITVGSDRKISCF 234 S + DG V+ ++ ++S H + V V+++P + G ++ SD K+S Sbjct: 72 SCSY--DGKVLIWKEENGRWSQI-AVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVV 128 Query: 235 DGKSGEFLKYIEDDQEPVQGGIFALSWL--------------DSQKFATVGADATIRVW 279 + K I D + G+ + SW +S+KF T GAD +++W Sbjct: 129 EFKENGTTSPIIIDAHAI--GVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 185 Score = 33.1 bits (74), Expect = 0.34, Method: Compositional matrix adjust. Identities = 33/131 (25%), Positives = 57/131 (43%), Gaps = 34/131 (25%) Query: 501 TYIAAGDVMGKILLYDLQS-REVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATG 559 T +A+ GK+L++ ++ R + + A H++ +N++ W P E G L+ Sbjct: 68 TILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGP--------LLLVA 119 Query: 560 SLDTNIFIYSVKR-----PMKIIKALNAHKDGVNNLLWETPSTL---------------V 599 S D + + K P+ I +AH GVN+ W P+T+ V Sbjct: 120 SSDGKVSVVEFKENGTTSPIII----DAHAIGVNSASW-APATIEEDGEHNGTKESRKFV 174 Query: 600 SSGADACIKRW 610 + GAD +K W Sbjct: 175 TGGADNLVKIW 185 >5YZG-2 nrPDB Length = 646 Score = 33.5 bits (75), Expect = 0.31, Method: Compositional matrix adjust. Identities = 27/102 (26%), Positives = 49/102 (48%), Gaps = 17/102 (16%) Query: 162 RINACHLKQSR--PMRSMTVGDD--GSVVFYQGPP--FKFSASDRTHHKQ---------- 205 +++ L Q R P+ V D G + ++ GPP +KF + +K Sbjct: 220 KLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFPKNVNWEYKTDTDLYEFAKC 279 Query: 206 GSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIED 247 ++ V FSPD G+ + T+GSDRK+ F +G+ ++ ++ Sbjct: 280 KAYPTSVCFSPD-GKKIATIGSDRKVRIFRFVTGKLMRVFDE 320 >6G51-g nrPDB Length = 317 Score = 33.1 bits (74), Expect = 0.36, Method: Compositional matrix adjust. Identities = 52/216 (24%), Positives = 90/216 (41%), Gaps = 36/216 (16%) Query: 334 TISGHNKGITALTVNP-----LISGSYDGRIMEWSSSSMHQD----------HSNLIVSL 378 T+ GHN +T + P ++S S D I+ W + + HS+ + + Sbjct: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 Query: 379 DNSKAQEYS-SISWDDTLKV----NGITKHEF-GSQPKVASA--NNDGFTAVLTNDDDLL 430 S +++ S SWD TL++ G T F G V S ++D V + D + Sbjct: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129 Query: 431 ILQSFTGDIIKSVRLNSPGSAVSL------SQNYVAVGLEEGNTIQVFKLSDLEVSFDLK 484 L + G +V+ S VS S N + V ++V+ L++ + LK Sbjct: 130 KLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK----LK 185 Query: 485 TPLRAKPSY---ISISPSETYIAAGDVMGKILLYDL 517 T Y +++SP + A+G G+ +L+DL Sbjct: 186 TNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL 221 Score = 30.0 bits (66), Expect = 3.4, Method: Compositional matrix adjust. Identities = 28/108 (25%), Positives = 48/108 (44%), Gaps = 14/108 (12%) Query: 304 VVATGNGRI-ISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGR 358 VV + +G+ +S S DGTL ++L + GH K + ++ + ++SGS D Sbjct: 69 VVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKT 128 Query: 359 IMEWSS------SSMHQDHSNLIVSLD---NSKAQEYSSISWDDTLKV 397 I W++ + + HS + + NS S WD +KV Sbjct: 129 IKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176 >3JB9-g nrPDB Length = 558 Score = 32.7 bits (73), Expect = 0.47, Method: Compositional matrix adjust. Identities = 27/137 (19%), Positives = 60/137 (43%), Gaps = 7/137 (5%) Query: 212 VEFSPDSGEFVITVGSDRKISCFD-GKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATV 270 + F P SG +++ D +I ++ L+ + P++ F+ D + F + Sbjct: 272 LRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQ---DGRSFLST 328 Query: 271 GADATIRVWDVTTSKCVQKWTLDKQQLGNQ-QVGVVATGNGRIISLSLDGTLNFYELGHD 329 D TI++WD KC+ + D+ L N + V ++ + D + +++ Sbjct: 329 SFDKTIKLWDTELGKCLNCFNSDR--LTNCVKFQVDPDKPNEFLAGTADKRILQFDIRSP 386 Query: 330 EVLKTISGHNKGITALT 346 ++++ H GI ++T Sbjct: 387 DIVQAYDHHLGGINSIT 403 >4L9O-A nrPDB Length = 349 Score = 32.7 bits (73), Expect = 0.48, Method: Compositional matrix adjust. Identities = 49/252 (19%), Positives = 110/252 (43%), Gaps = 45/252 (17%) Query: 311 RIISLSLDGTLNFYELG--HDEVLKTISGHNKGITALT-VNP-----LISGSYDGRIMEW 362 R+ + S D T+ +E+ + +++T+ GH + + +P L S SYDG+++ W Sbjct: 83 RLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVLIW 142 Query: 363 SSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAV 422 + + V+ + +S+SW HE+G P + A++DG ++ Sbjct: 143 KEDNGVWNK----VAEHSVHQASVNSVSW---------APHEYG--PVLLCASSDGKISI 187 Query: 423 LTNDD----DLLILQSFTGDIIKSVRLNSPGSA-VSLSQN---YVAVGLEEGNTIQVFKL 474 + D + +++Q ++ +N+ A +SL N +V+ G + N +++++ Sbjct: 188 VEFKDGGALEPIVIQG------HAIGVNAASWAPISLPDNTRRFVSGGCD--NLVKIWRY 239 Query: 475 SDLEVSFDLKTPLRAKPSY---ISISP---SETYIAAGDVMGKILLYDLQSREVKTSRWA 528 D +F + + + ++ SP S++YIA +L++ + K + Sbjct: 240 DDAAKTFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQP 299 Query: 529 FHTSKINAISWK 540 K + W+ Sbjct: 300 LTKEKFPDVCWR 311 >5XYI-g nrPDB Length = 335 Score = 32.7 bits (73), Expect = 0.50, Method: Compositional matrix adjust. Identities = 30/111 (27%), Positives = 53/111 (47%), Gaps = 16/111 (14%) Query: 263 DSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQ--VGVV-ATGNGRIISLSLDG 319 D+ T D+T+R+WD++T T K LG+++ +GV + N RIIS+ D Sbjct: 91 DASHLLTSSWDSTLRLWDLSTR------TTKKLFLGHKKDVLGVTFSPCNRRIISVGRDN 144 Query: 320 TLNFYE-LGHDEVLKTISGHNKGITALTV----NPLI--SGSYDGRIMEWS 363 + + LG ++ S + + +PL+ G +DG++ WS Sbjct: 145 QVKIWNILGENKAELQCSSWVTSVACAPMADETSPLVIAVGCWDGKVYIWS 195 Score = 30.4 bits (67), Expect = 2.4, Method: Compositional matrix adjust. Identities = 11/35 (31%), Positives = 21/35 (60%) Query: 549 EEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAH 583 +E ++A G D ++I+S+++ K+IK AH Sbjct: 175 DETSPLVIAVGCWDGKVYIWSIEKEAKLIKEFKAH 209 Score = 28.9 bits (63), Expect = 7.1, Method: Compositional matrix adjust. Identities = 13/20 (65%), Positives = 18/20 (90%), Gaps = 1/20 (5%) Query: 212 VEFSPDSGEFVITVGSDRKI 231 V+F+PD G++VIT GSDRK+ Sbjct: 216 VDFTPD-GKWVITGGSDRKV 234 >5A9Q-0 nrPDB Length = 380 Score = 32.3 bits (72), Expect = 0.59, Method: Compositional matrix adjust. Identities = 36/163 (22%), Positives = 70/163 (42%), Gaps = 31/163 (19%) Query: 222 VITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDV 281 ++TVG D +I+ F E ++ I++ + A+++L + + TV + +++WD Sbjct: 144 IVTVGEDGRINLFRADHKEAVRTIDNADSST---LHAVTFLRTPEILTVNSIGQLKIWDF 200 Query: 282 T------------TSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHD 329 T V +D+ NQQ VVATG DG L+ +++ Sbjct: 201 RQQGNEPSQILSLTGDRVPLHCVDRHP--NQQ-HVVATGGQ-------DGMLSIWDVRQG 250 Query: 330 EV-LKTISGHNKGITALTVNP-----LISGSYDGRIMEWSSSS 366 + + + H + + +P L + S DG + W +S+ Sbjct: 251 TMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDAST 293 Score = 28.5 bits (62), Expect = 8.5, Method: Compositional matrix adjust. Identities = 19/94 (20%), Positives = 36/94 (38%), Gaps = 11/94 (11%) Query: 253 QGGIFALSWLDSQKFATVGADATIRVW----DVTTSKCVQKWTLDKQQLG-------NQQ 301 G + L + D ++ + + V+ + T Q+WT G + Sbjct: 74 HGDVMDLQFFDQERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSAP 133 Query: 302 VGVVATGNGRIISLSLDGTLNFYELGHDEVLKTI 335 V N I+++ DG +N + H E ++TI Sbjct: 134 CTGVVCNNPEIVTVGEDGRINLFRADHKEAVRTI 167 >2HES-X nrPDB Length = 330 Score = 32.0 bits (71), Expect = 0.83, Method: Compositional matrix adjust. Identities = 29/116 (25%), Positives = 47/116 (40%), Gaps = 3/116 (2%) Query: 23 HLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLC 82 H+ + P+ +A VR D D V GH +V ++ F +G LC Sbjct: 158 HVIWHPSEALLASSSYDDT-VRIWKDYDDDWECVAVLNGHEGTVWSS-DFDKTEGVFRLC 215 Query: 83 SGDESGKVIVWGWTFDKESNSVEVNVKSEF-QVLAGPISDISWDFEGRRLCVVGEG 137 SG + V VW + D E + E ++ V + +++W F G V +G Sbjct: 216 SGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNGLIASVGADG 271 Score = 30.4 bits (67), Expect = 2.2, Method: Compositional matrix adjust. Identities = 19/60 (31%), Positives = 35/60 (58%), Gaps = 4/60 (6%) Query: 555 LVATGSLDTNIFIYSVKR-PMKIIKALN--AHKDGVNNLLWETPSTLVSSGA-DACIKRW 610 ++ATGS D I + SVK +I L+ AHK + ++ W ++L+++G+ D+ + W Sbjct: 26 ILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSFDSTVSIW 85 >3BG0-A nrPDB Length = 316 Score = 31.6 bits (70), Expect = 1.2, Method: Compositional matrix adjust. Identities = 28/108 (25%), Positives = 44/108 (40%), Gaps = 28/108 (25%) Query: 523 KTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLD--TNIFIYSVKRPMKIIKAL 580 K+ A H S +N++ W P + G ++A GS D ++ Y+ + ++ K Sbjct: 95 KSHEHAGHDSSVNSVCWAPHDYGL--------ILACGSSDGAISLLTYTGEGQWEVKKIN 146 Query: 581 NAHKDGVNNLLWE---TPSTLV---------------SSGADACIKRW 610 NAH G N + W P +L+ S G D IK W Sbjct: 147 NAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLW 194 >5OQL-X nrPDB Length = 630 Score = 31.2 bits (69), Expect = 1.4, Method: Compositional matrix adjust. Identities = 33/139 (23%), Positives = 69/139 (49%), Gaps = 13/139 (9%) Query: 197 ASDRTH--HKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQG 254 A+D+T+ H + V V+ S D G+FV+T G+D+++ ++ + +K ++ V G Sbjct: 237 ANDKTYQGHLKAPLV--VKASQD-GKFVVTGGADKRLVVYNAADLKPIKAFTQHRDAVTG 293 Query: 255 GIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIIS 314 F + + + D T++VW + V+ TL Q ++ + + A G R +S Sbjct: 294 LAFRRG---TNQLYSCSKDRTVKVWSLDELAYVE--TLFGHQ--DEILDIDALGQERCVS 346 Query: 315 L-SLDGTLNFYELGHDEVL 332 + + D T ++++ + L Sbjct: 347 VGARDRTARYWKVPEESQL 365 >6CHG-A nrPDB Length = 312 Score = 31.2 bits (69), Expect = 1.5, Method: Compositional matrix adjust. Identities = 20/78 (25%), Positives = 37/78 (47%), Gaps = 5/78 (6%) Query: 262 LDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVAT----GNGRIISL-S 316 DS ++ D IR++D + C++ T DK + V ++T NG+ + + S Sbjct: 148 FDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVKS 207 Query: 317 LDGTLNFYELGHDEVLKT 334 LD + +E V++T Sbjct: 208 LDNVVKLWEYTRGTVVRT 225 Score = 30.0 bits (66), Expect = 3.2, Method: Compositional matrix adjust. Identities = 12/43 (27%), Positives = 25/43 (58%), Gaps = 1/43 (2%) Query: 562 DTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSGAD 604 +T++ +Y + K++K HK+ +N L W S ++SG++ Sbjct: 33 NTDMLVYEISSS-KMMKLTTTHKECINCLCWSPDSKCIASGSE 74 >4YHC-A nrPDB Length = 468 Score = 31.2 bits (69), Expect = 1.5, Method: Compositional matrix adjust. Identities = 22/83 (26%), Positives = 37/83 (44%), Gaps = 2/83 (2%) Query: 265 QKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFY 324 + FA+VG D ++ VWD+ + K L K+Q+ + G +SL TL Sbjct: 43 KTFASVGLDRSLVVWDL--RQWCTKLVLSKEQMPRTLKAIALDPQGNYVSLFSKDTLFIL 100 Query: 325 ELGHDEVLKTISGHNKGITALTV 347 + ++ S H+K + L V Sbjct: 101 NVESPSLMLQHSYHSKPNSKLNV 123 >5Y1U-A nrPDB Length = 456 Score = 30.4 bits (67), Expect = 2.3, Method: Compositional matrix adjust. Identities = 47/227 (20%), Positives = 86/227 (37%), Gaps = 35/227 (15%) Query: 78 SQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEG 137 S +L S + + +W + + V V+ K+ F + D+SW L G Sbjct: 221 SGHLLSASDDHTICLWDISAVPKEGKV-VDAKTIFTGHTAVVEDVSWHLLHESL--FGSV 277 Query: 138 RDNFGVFISWDSGNS-----LGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPP 192 D+ + I WD+ ++ V H+ +N T D +V + Sbjct: 278 ADDQKLMI-WDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRN 336 Query: 193 FKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEP- 251 K HK F V++SP + + + G+DR+++ +D L I ++Q P Sbjct: 337 LKLKLHSFESHKDEIF--QVQWSPHNETILASSGTDRRLNVWD------LSKIGEEQSPE 388 Query: 252 -----------VQGG----IFALSWLDSQKF--ATVGADATIRVWDV 281 + GG I SW ++ + +V D ++VW + Sbjct: 389 DAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 435 Score = 28.5 bits (62), Expect = 9.0, Method: Compositional matrix adjust. Identities = 25/141 (17%), Positives = 57/141 (40%), Gaps = 25/141 (17%) Query: 489 AKPSYISISP-SETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGAN 547 A+ + +S +P SE +A G + L+DL++ ++K + H +I + W P Sbjct: 305 AEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPH----- 359 Query: 548 EEEIEEDLVATGSLDTNIFIYSVKR-------------PMKIIKALNAHKDGVNNLLWET 594 E ++A+ D + ++ + + P +++ H +++ W Sbjct: 360 ----NETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNP 415 Query: 595 --PSTLVSSGADACIKRWNVV 613 P + S D ++ W + Sbjct: 416 NEPWVICSVSEDNIMQVWQMA 436 >6HQA-B nrPDB Length = 722 Score = 30.4 bits (67), Expect = 2.5, Method: Compositional matrix adjust. Identities = 19/68 (27%), Positives = 36/68 (52%), Gaps = 5/68 (7%) Query: 215 SPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSW-LDSQKFATVGAD 273 SPD G ++ + G D + +D +G +K + + I++L++ + + GAD Sbjct: 588 SPD-GRWLASAGEDSVVCLWDISTGRRIKAMRGHG---RSSIYSLAFSREGTVLVSTGAD 643 Query: 274 ATIRVWDV 281 ++RVWDV Sbjct: 644 NSVRVWDV 651 Score = 30.0 bits (66), Expect = 2.9, Method: Compositional matrix adjust. Identities = 21/78 (26%), Positives = 39/78 (50%), Gaps = 6/78 (7%) Query: 212 VEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSW-LDSQKFATV 270 VEF P+S ++ T SD+ +D GE ++ G I L+ D + A+ Sbjct: 543 VEFHPNS-TYLFTGSSDKTARMWDIARGECVRVFMGHS----GAINCLAVSPDGRWLASA 597 Query: 271 GADATIRVWDVTTSKCVQ 288 G D+ + +WD++T + ++ Sbjct: 598 GEDSVVCLWDISTGRRIK 615 Score = 30.0 bits (66), Expect = 3.0, Method: Compositional matrix adjust. Identities = 36/164 (21%), Positives = 62/164 (37%), Gaps = 15/164 (9%) Query: 209 VRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFA 268 V V+FSPD+ ++I+ D+ + + + L + V F+ FA Sbjct: 456 VYGVDFSPDN-RYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKFSPM---GHYFA 511 Query: 269 TVGADATIRVWDVTTSKCVQKWTLD--KQQLGNQQVGVVATGNGRIISLSLDGTLNFYEL 326 T D T R+W C + L L + + + + S D T +++ Sbjct: 512 TASHDQTARLW-----SCDHIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTARMWDI 566 Query: 327 GHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSS 366 E ++ GH+ I L V+P L S D + W S+ Sbjct: 567 ARGECVRVFMGHSGAINCLAVSPDGRWLASAGEDSVVCLWDIST 610 >5WBU-D nrPDB Length = 328 Score = 30.0 bits (66), Expect = 2.8, Method: Compositional matrix adjust. Identities = 32/112 (28%), Positives = 46/112 (41%), Gaps = 8/112 (7%) Query: 171 SRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRK 230 S P+ T G D +V F+Q RT Q S V +E +PD +I + Sbjct: 12 SDPVILATAGYDHTVRFWQA---HSGICTRTVQHQDSQVNALEVTPDRS--MIAAAGYQH 66 Query: 231 ISCFDGKSGEFLKYIEDDQEPVQGGIFALSWL-DSQKFATVGADATIRVWDV 281 I +D S I D V I ++ + D + T G D T R+WD+ Sbjct: 67 IRMYDLNSNNPNPIISYDG--VNKNIASVGFHEDGRWMYTGGEDCTARIWDL 116 >5CXB-B nrPDB Length = 369 Score = 30.0 bits (66), Expect = 3.4, Method: Compositional matrix adjust. Identities = 42/159 (26%), Positives = 64/159 (40%), Gaps = 27/159 (16%) Query: 467 NTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDL--QSREVKT 524 +I+ + L LE+ + P S + P + G ++L +DL +R KT Sbjct: 222 RSIRCYDLQKLEL-VKIVQPGAKWISSFDVHPGGDNLVVGSYDKRLLWHDLDLSNRPYKT 280 Query: 525 SRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRP--------MKI 576 R FHT I A+ + KG L A S D ++ I+ K P + Sbjct: 281 MR--FHTEAIRAVRF---HKGGLP------LFADASDDGSLQIFHGKVPNDQLENPTIVP 329 Query: 577 IKALNAHKD----GVNNLLWETPST-LVSSGADACIKRW 610 +K L HK GV ++ W VS+GAD + W Sbjct: 330 VKMLKGHKVVNKLGVLDIDWHPREPWCVSAGADGTARLW 368 >3W15-A nrPDB Length = 368 Score = 30.0 bits (66), Expect = 3.4, Method: Compositional matrix adjust. Identities = 25/85 (29%), Positives = 38/85 (44%), Gaps = 13/85 (15%) Query: 204 KQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGK--SGEFLKYIEDDQEPVQGGIFALSW 261 K + V +FSP V++ + S FD + SG+ + V G+ AL+ Sbjct: 174 KNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGK-----NQNNFLVHSGLEALT- 227 Query: 262 LDSQKF-----ATVGADATIRVWDV 281 D K+ AT G D IR+WD+ Sbjct: 228 CDFNKYRPYVVATGGVDNAIRIWDI 252 >5GRS-A nrPDB Length = 396 Score = 29.6 bits (65), Expect = 3.6, Method: Compositional matrix adjust. Identities = 22/83 (26%), Positives = 35/83 (42%), Gaps = 2/83 (2%) Query: 265 QKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFY 324 + FA+VG D + VWD+ + K L K+Q+ + G +SL TL Sbjct: 43 KTFASVGLDRCLVVWDL--RQWCTKLVLSKEQMPRTLKAIALDPQGNYVSLFSKDTLFIL 100 Query: 325 ELGHDEVLKTISGHNKGITALTV 347 + ++ S H K + L V Sbjct: 101 NVESPSLMLQHSYHCKPNSKLNV 123 >4A11-B nrPDB Length = 408 Score = 29.6 bits (65), Expect = 4.0, Method: Compositional matrix adjust. Identities = 44/175 (25%), Positives = 72/175 (41%), Gaps = 28/175 (16%) Query: 193 FKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDR--KISCFDGKSGEFLKYIEDDQE 250 F F + +HH SP S + + R K+ D KSG ++ ++ Sbjct: 138 FNFEETVYSHH----------MSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQ 187 Query: 251 PVQGGIFALSWLDSQKF--ATVGADATIRVWDV-TTSKCVQKWTLDKQQLGNQQVGVVAT 307 I A+SW + AT AD+ +++WDV S C+ TLD Q G + V + Sbjct: 188 E----ILAVSWSPRYDYILATASADSRVKLWDVRRASGCLI--TLD-QHNGKKSQAVESA 240 Query: 308 G---NGRIISLSL--DGTLNFYELGHDEVLKTISGHNKGITALTVNPLISGSYDG 357 NG++ L DG L+ +G D ++ + N T + + + S G Sbjct: 241 NTAHNGKVNGLCFTSDG-LHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKG 294 >3SH1-A nrPDB Length = 230 Score = 29.3 bits (64), Expect = 5.1, Method: Compositional matrix adjust. Identities = 20/72 (27%), Positives = 34/72 (47%), Gaps = 5/72 (6%) Query: 512 ILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDT-NIFIYSV 570 I+ D + EV W + K+N++ W P E G I + + + T +I YS Sbjct: 49 IVKADSSTNEVDLVYWEQQSWKLNSLMWDPNEYG----NITDFRTSAADIWTPDITAYSS 104 Query: 571 KRPMKIIKALNA 582 RP++++ NA Sbjct: 105 TRPVQVLSPQNA 116 >3JZG-A nrPDB Length = 402 Score = 29.3 bits (64), Expect = 5.2, Method: Compositional matrix adjust. Identities = 16/40 (40%), Positives = 20/40 (50%), Gaps = 1/40 (2%) Query: 192 PFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKI 231 P K + THHK G+ +R FS DS +I V D I Sbjct: 357 PHKAKCTTLTHHKCGAAIRQTSFSRDSS-ILIAVCDDASI 395 >4A5P-A nrPDB Length = 383 Score = 29.3 bits (64), Expect = 5.3, Method: Compositional matrix adjust. Identities = 20/74 (27%), Positives = 38/74 (51%), Gaps = 5/74 (6%) Query: 335 ISGHNKGITALTVNPLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDT 394 I+ N I AL + P++S SY+ R++ W S ++ +N+ + +++ + Y +S Sbjct: 130 ITDENGDIDALGI-PVVSTSYNERVISWVDVSYTENLTNIDAKIKSAQDEFYHQLSQALL 188 Query: 395 LKVNGITKHEFGSQ 408 +N I FG Q Sbjct: 189 NNINEI----FGIQ 198 >5N4A-A nrPDB Length = 771 Score = 29.3 bits (64), Expect = 5.7, Method: Compositional matrix adjust. Identities = 21/81 (25%), Positives = 37/81 (45%), Gaps = 12/81 (14%) Query: 207 SFVRDVEFSPDSGEFVITVGSDR-KISCFDG------KSGEFLKYIEDDQEPVQGGIFAL 259 ++ D+ + P S + G+D ++C DG ++G K IE + G +L Sbjct: 55 AYFTDMHWYPVSSKKTQAGGTDVFAVACTDGSVKILSRTGRVEKSIEGHK----GACISL 110 Query: 260 SW-LDSQKFATVGADATIRVW 279 W D AT G D ++++W Sbjct: 111 RWSYDGTALATAGEDGSVKIW 131 >5CXC-A nrPDB Length = 510 Score = 29.3 bits (64), Expect = 5.8, Method: Compositional matrix adjust. Identities = 26/103 (25%), Positives = 43/103 (41%), Gaps = 18/103 (17%) Query: 273 DATIRVWDVTTSKCVQKWTLDKQQL--------GNQQVGVVATGNGRIISLSLDGTLNFY 324 D T+R D+TT + V TL L G + A + R I++ ++ Sbjct: 334 DHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITM-----VDPR 388 Query: 325 ELGHDEVLKTISGHNKGITALTVNP-----LISGSYDGRIMEW 362 + T+ GH + +L+ +P L+SGS+DG W Sbjct: 389 ASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVW 431 Score = 28.5 bits (62), Expect = 9.4, Method: Compositional matrix adjust. Identities = 13/29 (44%), Positives = 17/29 (58%) Query: 256 IFALSWLDSQKFATVGADATIRVWDVTTS 284 I A +L S + A+ G D T+RVW T S Sbjct: 195 IKAAKFLTSDRLASAGMDRTVRVWKYTES 223 >4XYI-A nrPDB Length = 430 Score = 28.9 bits (63), Expect = 6.2, Method: Compositional matrix adjust. Identities = 31/139 (22%), Positives = 57/139 (41%), Gaps = 20/139 (14%) Query: 156 VSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQG--SFVRDVE 213 V H Q +N T D +V + + R H +G V +V+ Sbjct: 277 VKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRL----NQRLHTLEGHEDEVYNVQ 332 Query: 214 FSPDSGEFVITVGSDRKISCFD-GKSGEFLKYIEDDQEPVQGGIFA----------LSWL 262 +SP ++T +DR++ +D K GE + +ED ++ +F LSW Sbjct: 333 WSPHDEPILVTSSTDRRVCVWDLSKIGEE-QTVEDSEDGAPELMFMHGGHTNRVSDLSWN 391 Query: 263 DSQKF--ATVGADATIRVW 279 + K+ A++ D +++W Sbjct: 392 PNNKWVLASLADDNILQIW 410 >3C9C-A nrPDB Length = 432 Score = 28.9 bits (63), Expect = 7.7, Method: Compositional matrix adjust. Identities = 25/141 (17%), Positives = 57/141 (40%), Gaps = 25/141 (17%) Query: 489 AKPSYISISP-SETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGAN 547 A+ + +S +P SE +A G + L+DL++ ++K + H +I + W P Sbjct: 280 AEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPH----- 334 Query: 548 EEEIEEDLVATGSLDTNIFIYSVKR-------------PMKIIKALNAHKDGVNNLLW-- 592 E ++A+ D + ++ + + P +++ H +++ W Sbjct: 335 ----NETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNP 390 Query: 593 ETPSTLVSSGADACIKRWNVV 613 P + S D ++ W + Sbjct: 391 NEPWIICSVSEDNIMQVWQMA 411 >3OP1-A nrPDB Length = 308 Score = 28.5 bits (62), Expect = 8.8, Method: Compositional matrix adjust. Identities = 27/94 (28%), Positives = 38/94 (40%), Gaps = 8/94 (8%) Query: 173 PMRSMTVGDD--GSVVFYQGPPFKFSASDRTHH-KQGSFVRDVEFSPDSGEFVITVGSDR 229 P R M V + G + Y P DRT+ G +V DVE + +VG + Sbjct: 191 PSRGMVVHGNARGRTIGY--PTANLVLLDRTYMPADGVYVVDVEIQRQKYRAMASVGKN- 247 Query: 230 KISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLD 263 FDG+ F I D + + G + WLD Sbjct: 248 --VTFDGEEARFEVNIFDFNQDIYGETVMVYWLD 279 >3I2N-A nrPDB Length = 357 Score = 28.5 bits (62), Expect = 9.6, Method: Compositional matrix adjust. Identities = 21/79 (26%), Positives = 39/79 (49%), Gaps = 7/79 (8%) Query: 510 GKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYS 569 G I LY++Q ++K R K I K GA +++ +ATG N+ I++ Sbjct: 44 GVIQLYEIQHGDLKLLR---EIEKAKPI--KCGTFGATS--LQQRYLATGDFGGNLHIWN 96 Query: 570 VKRPMKIIKALNAHKDGVN 588 ++ P + ++ HK+ +N Sbjct: 97 LEAPEMPVYSVKGHKEIIN 115 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1PI6-A nrPDB 817 0.0 1NR0-A nrPDB 489 e-138 5FL8-q nrPDB 306 3e-83 5M25-A nrPDB 247 8e-66 6QX9-5O nrPDB 241 8e-64 2H9P-A nrPDB 239 4e-63 6N9G-C nrPDB 233 1e-61 6F3T-A nrPDB 214 1e-55 6MZM-G nrPDB 205 6e-53 4V6W-Ag nrPDB 198 7e-51 5FVM-C nrPDB 193 2e-49 3DM0-A nrPDB 191 1e-48 6HHQ-h nrPDB 180 2e-45 6QX9-4B nrPDB 178 6e-45 6ELZ-p nrPDB 174 1e-43 5NNZ-B nrPDB 172 5e-43 6ID0-T nrPDB 156 2e-38 5WYJ-BC nrPDB 156 3e-38 6Q8F-A nrPDB 151 6e-37 5Z56-q nrPDB 149 3e-36 5Y88-O nrPDB 148 5e-36 4LG8-A nrPDB 144 9e-35 5K1B-B nrPDB 137 2e-32 3JB9-S nrPDB 136 3e-32 6GMH-W nrPDB 117 2e-26 Sequences not found previously or not previously below threshold: 6G51-g nrPDB 191 1e-48 5MZH-A nrPDB 176 2e-44 4V8M-A7 nrPDB 174 8e-44 5UZ7-B nrPDB 168 5e-42 6EMK-B nrPDB 166 3e-41 5OPT-p nrPDB 166 3e-41 6HQA-B nrPDB 162 4e-40 4V7E-Bg nrPDB 157 2e-38 3JAP-g nrPDB 156 3e-38 1VYH-C nrPDB 148 1e-35 3JB9-L nrPDB 144 1e-34 3MKQ-A nrPDB 141 6e-34 4BTS-AR nrPDB 138 7e-33 2YNP-A nrPDB 138 8e-33 5NZU-C nrPDB 135 5e-32 5GAN-H nrPDB 130 2e-30 5WYK-BB nrPDB 115 4e-26 5XYI-g nrPDB 115 9e-26 6QDV-o nrPDB 111 7e-25 5YZG-W nrPDB 111 1e-24 5OQL-L nrPDB 110 2e-24 3JB9-g nrPDB 108 6e-24 3FM0-A nrPDB 108 6e-24 5WJC-A nrPDB 106 2e-23 5WLC-LO nrPDB 103 3e-22 5OQL-d nrPDB 101 7e-22 5I2T-A nrPDB 101 1e-21 6BX3-A nrPDB 100 1e-21 5OQL-J nrPDB 99 2e-21 5CXC-A nrPDB 99 5e-21 6EOJ-D nrPDB 98 7e-21 5G04-R nrPDB 96 3e-20 4GGA-A nrPDB 96 5e-20 5LCW-Q nrPDB 95 8e-20 5L9T-R nrPDB 93 2e-19 4XYI-A nrPDB 93 3e-19 4N14-A nrPDB 93 3e-19 3ODT-A nrPDB 93 4e-19 6CHG-A nrPDB 86 4e-17 4J0W-A nrPDB 86 4e-17 4XFV-A nrPDB 85 7e-17 4YCZ-A nrPDB 85 9e-17 2AQ5-A nrPDB 84 2e-16 6J6H-n nrPDB 83 3e-16 3C9C-A nrPDB 83 3e-16 5WBU-D nrPDB 82 5e-16 5Y1U-A nrPDB 82 7e-16 3CFV-B nrPDB 82 8e-16 4L9O-A nrPDB 80 2e-15 4A11-B nrPDB 80 2e-15 5WLC-LJ nrPDB 80 3e-15 5WYJ-BE nrPDB 79 5e-15 2HES-X nrPDB 79 7e-15 3JRO-A nrPDB 78 1e-14 5MWJ-A nrPDB 76 4e-14 3W15-A nrPDB 76 5e-14 4AEZ-A nrPDB 75 7e-14 5WLC-LU nrPDB 75 1e-13 2PM9-A nrPDB 74 1e-13 4G56-B nrPDB 74 1e-13 4U1E-I nrPDB 74 2e-13 5K0Y-T nrPDB 73 3e-13 3JRP-A nrPDB 73 5e-13 5A9Q-2 nrPDB 71 1e-12 4BZK-B nrPDB 71 1e-12 5A31-R nrPDB 71 2e-12 5FA5-B nrPDB 70 2e-12 4BH6-A nrPDB 70 3e-12 3BG0-A nrPDB 68 9e-12 5BJS-A nrPDB 68 2e-11 3ACP-A nrPDB 67 2e-11 6CB1-s nrPDB 67 3e-11 6F1U-h nrPDB 66 6e-11 5A9Q-0 nrPDB 66 6e-11 6EM1-m nrPDB 66 6e-11 6C0F-s nrPDB 65 7e-11 4OWR-A nrPDB 65 1e-10 6E29-D nrPDB 65 1e-10 5OQL-X nrPDB 64 2e-10 5WLC-LN nrPDB 64 2e-10 3JZG-A nrPDB 63 4e-10 4J0X-A nrPDB 60 3e-09 4E5Z-B nrPDB 60 3e-09 3F3P-A nrPDB 60 3e-09 5WLC-SG nrPDB 60 4e-09 5YZG-2 nrPDB 58 9e-09 5K19-A nrPDB 58 1e-08 2P9P-C nrPDB 56 3e-08 4PSX-B nrPDB 56 3e-08 5CXB-B nrPDB 56 5e-08 5A9Q-7 nrPDB 55 7e-08 5N4A-A nrPDB 55 1e-07 6BX3-B nrPDB 53 5e-07 5OV3-A nrPDB 51 2e-06 3I2N-A nrPDB 51 2e-06 6CHG-D nrPDB 50 2e-06 3EI3-B nrPDB 50 4e-06 5AMS-A nrPDB 48 8e-06 5WLC-LS nrPDB 47 2e-05 5TF2-A nrPDB 47 2e-05 2VDU-B nrPDB 47 3e-05 5M89-A nrPDB 45 7e-05 5MC6-j nrPDB 44 2e-04 2I3T-A nrPDB 44 2e-04 5WLC-LH nrPDB 44 2e-04 5WLC-LW nrPDB 42 6e-04 5LTD-A nrPDB 42 0.001 6CVZ-A nrPDB 40 0.004 5CWW-B nrPDB 36 0.060 6N8P-A nrPDB 35 0.14 2VR2-A nrPDB 33 0.40 4IMM-A nrPDB 33 0.43 3DWL-C nrPDB 32 0.73 5UE8-A nrPDB 31 1.6 4YHC-A nrPDB 31 1.9 5MVH-A nrPDB 30 3.2 3ZYZ-A nrPDB 30 4.0 5GRS-A nrPDB 29 6.7 >1PI6-A nrPDB Length = 615 Score = 817 bits (2110), Expect = 0.0, Method: Composition-based stats. Identities = 614/615 (99%), Positives = 614/615 (99%) Query: 1 MSSISLKEIIPPQPSTQRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFT 60 MSSISLKEIIPPQPSTQRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFT Sbjct: 1 MSSISLKEIIPPQPSTQRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFT 60 Query: 61 GHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPIS 120 GHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPIS Sbjct: 61 GHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPIS 120 Query: 121 DISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVG 180 DISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVG Sbjct: 121 DISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVG 180 Query: 181 DDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGE 240 DDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGE Sbjct: 181 DDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGE 240 Query: 241 FLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQ 300 FLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQ Sbjct: 241 FLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQ 300 Query: 301 QVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPLISGSYDGRIM 360 QVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPLISGSYDGRIM Sbjct: 301 QVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPLISGSYDGRIM 360 Query: 361 EWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFT 420 EWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFT Sbjct: 361 EWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFT 420 Query: 421 AVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVS 480 AVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVS Sbjct: 421 AVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVS 480 Query: 481 FDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWK 540 FDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAF TSKINAISWK Sbjct: 481 FDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFRTSKINAISWK 540 Query: 541 PAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVS 600 PAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVS Sbjct: 541 PAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVS 600 Query: 601 SGADACIKRWNVVLE 615 SGADACIKRWNVVLE Sbjct: 601 SGADACIKRWNVVLE 615 >1NR0-A nrPDB Length = 611 Score = 489 bits (1258), Expect = e-138, Method: Composition-based stats. Identities = 197/646 (30%), Positives = 316/646 (48%), Gaps = 71/646 (10%) Query: 1 MSSISLKEIIPPQPSTQRNFTTHLSYDPTTNAIAYPCGKSAF---VRCLDDGDSKVPPVV 57 MS S + P P T R L P + I Y G S + V L D + Sbjct: 1 MSEFSQTALFPSLPRTARGTAVVLGNTPAGDKIQYCNGTSVYTVPVGSLTDTE------- 53 Query: 58 QFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAG 117 +T H S T K SP Y SGD G V +W ++ +K+ V +G Sbjct: 54 IYTEH-SHQTTVAKTSP--SGYYCASGDVHGNVRIW------DTTQTTHILKTTIPVFSG 104 Query: 118 PISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSM 177 P+ DISWD E +R+ VGEGR+ FG +D+G S G ++G ++ +N+ K SRP R + Sbjct: 105 PVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRII 164 Query: 178 TVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGK 237 + DD +V ++GPPFKF ++ H K FV V ++PD G + G D I ++G Sbjct: 165 SGSDDNTVAIFEGPPFKFKSTFGEHTK---FVHSVRYNPD-GSLFASTGGDGTIVLYNGV 220 Query: 238 SGEFLKYIEDD---QEPVQGGIFALSW-LDSQKFATVGADATIRVWDVTTSKCVQKWTLD 293 G EDD G +F L+W D K A+ AD TI++W+V T K V+K Sbjct: 221 DGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLK-VEKTIPV 279 Query: 294 KQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVN----P 349 ++ +QQ+G++ T ++S+S +G +NF + + GHNK ITAL+ + Sbjct: 280 GTRIEDQQLGIIWTKQA-LVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKT 338 Query: 350 LISGSYDGRIMEWSSSSMHQD------HSNLIVSLDNSKAQEYSSISWDDTLKV------ 397 L S +G I W S+ + H+ +I + + + ++SWDD LKV Sbjct: 339 LFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGS 398 Query: 398 ----NGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIK-SVRLNSPGSAV 452 + ++ SQP + + DG AV + I G + + + NS A+ Sbjct: 399 GVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSH--GKLTEVPISYNSSCVAL 456 Query: 453 SLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLR-AKPSYISISPSETYIAAGDVMGK 511 S + +VAVG ++ + + V+KLS VS ++KT + A+ + ++ S + ++ A D K Sbjct: 457 SNDKQFVAVGGQD-SKVHVYKLSGASVS-EVKTIVHPAEITSVAFSNNGAFLVATDQSRK 514 Query: 512 ILLYDLQS--REVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYS 569 ++ Y + + T+ W FHT+K+ +SW P + +ATGSLD ++ +++ Sbjct: 515 VIPYSVANNFELAHTNSWTFHTAKVACVSWSP----------DNVRLATGSLDNSVIVWN 564 Query: 570 VKRPMK---IIKALNAHKDGVNNLLWETPSTLVSSGADACIKRWNV 612 + +P IIK +A VN+++W +T+VS+G D+ IK WNV Sbjct: 565 MNKPSDHPIIIKGAHA-MSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 Score = 48.8 bits (114), Expect = 6e-06, Method: Composition-based stats. Identities = 28/198 (14%), Positives = 62/198 (31%), Gaps = 7/198 (3%) Query: 85 DESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVF 144 G + V S + + S ++ + + + V G+ Sbjct: 420 SADGDIAVAACYKHIAIYSHGKLTEVPISYNS---SCVALSNDKQFVAVGGQDSKVHVYK 476 Query: 145 ISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHK 204 +S S + + + H I + + T + + F+ A + Sbjct: 477 LSGASVSEVKTIV-HPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFEL-AHTNSWTF 534 Query: 205 QGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDS 264 + V V +SPD+ + T D + ++ I + ++ WL+ Sbjct: 535 HTAKVACVSWSPDN-VRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVN-SVIWLNE 592 Query: 265 QKFATVGADATIRVWDVT 282 + G D+ I+ W+V Sbjct: 593 TTIVSAGQDSNIKFWNVP 610 >5FL8-q nrPDB Length = 515 Score = 306 bits (782), Expect = 3e-83, Method: Composition-based stats. Identities = 93/451 (20%), Positives = 169/451 (37%), Gaps = 87/451 (19%) Query: 185 VVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKY 244 VF P + S++ H GS + F+P + ++T D +D + + Sbjct: 125 AVFKVKPVTRSSSAIAGH---GSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHT 181 Query: 245 IEDDQEPVQGGIFALSW-LDSQKFATVGADATIRVWDVTTSKCV-QKWTLDK---QQLGN 299 ++ + +SW D + AT D TIR+WD + +C+ L Sbjct: 182 LKGHY----NWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSW 237 Query: 300 QQVGVVATGN-GRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALT---VNPLISGSY 355 + + +V G+ R+ S S DGT+ ++ T+SGH ++ + L SGS+ Sbjct: 238 EPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQGLLYSGSH 297 Query: 356 DGRIMEWSSSSMHQDHSNLIVSLDNSKAQ--EYSSISWDDTLKVNGITKHEFGSQPKVAS 413 D + W +S +++ S A + S+S D L++ F K S Sbjct: 298 DRTVRVWDINSQ-----GRCINILKSHAHWVNHLSLSTDYALRIGA-----FDHTGKKPS 347 Query: 414 ANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFK 473 + L +NY + + GN+ ++ Sbjct: 348 TPEEAQKKAL--------------------------------ENYEKICKKNGNSEEMMV 375 Query: 474 LSDLEVSFDLKTPLRA-KP-----------SYISISPSETYIAAGDVMGKILLYDLQSRE 521 + + + L PL++ KP ++++ SP YI + I L+D R+ Sbjct: 376 TASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWD--GRD 433 Query: 522 VK-TSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKAL 580 K S + H + + ++W + L+ + S DT + ++ V R K+ L Sbjct: 434 GKFISTFRGHVASVYQVAWSSDCR----------LLVSCSKDTTLKVWDV-RTRKLSVDL 482 Query: 581 NAHKDGVNNLLWETPSTLVSSGA-DACIKRW 610 HKD V + W V SG D ++ W Sbjct: 483 PGHKDEVYTVDWSVDGKRVCSGGKDKMVRLW 513 Score = 134 bits (336), Expect = 1e-31, Method: Composition-based stats. Identities = 51/357 (14%), Positives = 112/357 (31%), Gaps = 66/357 (18%) Query: 54 PPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWT-FDKESNSVEVNVKSEF 112 P+ GH + V+ S + + +G + +W +++ + K Sbjct: 177 TPMHTLKGHYNWVLCV---SWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWIT 233 Query: 113 QVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGN--SLGEVSGHSQRINACHLKQ 170 + PI + + RL + G WD+ + +SGH+ ++ K Sbjct: 234 SLSWEPIHLVKPGSK-PRLASSSKD----GTIKIWDTVSRVCQYTMSGHTNSVSCV--KW 286 Query: 171 SRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSG----------- 219 + D +V + +V + S D Sbjct: 287 GGQGLLYSGSHDRTVRVWDINSQ--GRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGK 344 Query: 220 ---------------------------EFVITVGSDRKISCFD-GKSGEFLKYIEDDQEP 251 E ++T D + ++ KS + + + Q+ Sbjct: 345 KPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKL 404 Query: 252 VQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGR 311 V F+ D + + D +I++WD K + + + V + + R Sbjct: 405 VNHVAFS---PDGRYIVSASFDNSIKLWDGRDGKFISTFRGHVASVYQ----VAWSSDCR 457 Query: 312 I-ISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVN----PLISGSYDGRIMEWS 363 + +S S D TL +++ ++ + GH + + + + SG D + W+ Sbjct: 458 LLVSCSKDTTLKVWDVRTRKLSVDLPGHKDEVYTVDWSVDGKRVCSGGKDKMVRLWT 514 Score = 66.9 bits (161), Expect = 3e-11, Method: Composition-based stats. Identities = 38/200 (19%), Positives = 71/200 (35%), Gaps = 17/200 (8%) Query: 424 TNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDL 483 T D L+ +K V +S A S + +T + + + Sbjct: 113 TEDQITLLYTPRAVFKVKPVTRSSSAIAGHGSTILCSAFAP--HTSSRMVTGAGDNTARI 170 Query: 484 K-----TPLRAKPSY------ISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTS 532 TP+ + +S SP IA G + I L+D +S + H+ Sbjct: 171 WDCDTQTPMHTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSK 230 Query: 533 KINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLW 592 I ++SW+P + + +A+ S D I I+ ++ H + V+ + W Sbjct: 231 WITSLSWEP---IHLVKPGSKPRLASSSKDGTIKIWDTV-SRVCQYTMSGHTNSVSCVKW 286 Query: 593 ETPSTLVSSGADACIKRWNV 612 L S D ++ W++ Sbjct: 287 GGQGLLYSGSHDRTVRVWDI 306 Score = 41.4 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 20/116 (17%), Positives = 41/116 (35%), Gaps = 14/116 (12%) Query: 23 HLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLC 82 H+++ P I ++ ++ D D K + F GH +SV + L Sbjct: 407 HVAFSPDGRYIVSASFDNS-IKLWDGRDGKF--ISTFRGHVASVYQVA---WSSDCRLLV 460 Query: 83 SGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGR 138 S + + VW + + + + W +G+R+C G+ + Sbjct: 461 SCSKDTTLKVWDVR--------TRKLSVDLPGHKDEVYTVDWSVDGKRVCSGGKDK 508 >5M25-A nrPDB Length = 434 Score = 247 bits (631), Expect = 8e-66, Method: Composition-based stats. Identities = 79/333 (23%), Positives = 131/333 (39%), Gaps = 39/333 (11%) Query: 49 GDSKVPPV-----VQFT--GHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKES 101 SK PV ++FT GH + V++VKFSP ++L S + +WG K Sbjct: 124 TQSKPTPVKPNYALKFTLAGH-TKAVSSVKFSP--NGEWLASSSADKLIKIWGAYDGK-- 178 Query: 102 NSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWD--SGNSLGEVSGH 159 + ISD++W + L + + WD SG L + GH Sbjct: 179 ------FEKTISGHKLGISDVAWSSDSNLLVSASDDK----TLKIWDVSSGKCLKTLKGH 228 Query: 160 SQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSG 219 S + C+ ++ D SV + K +T V V F+ D G Sbjct: 229 SNYVFCCNFNPQSN-LIVSGSFDESVRIWDVKTGKC---LKTLPAHSDPVSAVHFNRD-G 283 Query: 220 EFVITVGSDRKISCFDGKSGEFLKY-IEDDQEPVQGGIFALSWLDSQKFATVGADATIRV 278 +++ D +D SG+ LK I+DD PV F+ + + D T+++ Sbjct: 284 SLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS---PNGKYILAATLDNTLKL 340 Query: 279 WDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGH 338 WD + KC++ +T K + TG I+S S D + + L E+++ + GH Sbjct: 341 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 400 Query: 339 NKGITALTVNP----LISGS--YDGRIMEWSSS 365 + + +P + S + D I W S Sbjct: 401 TDVVISTACHPTENIIASAALENDKTIKLWKSD 433 Score = 121 bits (304), Expect = 7e-28, Method: Composition-based stats. Identities = 62/331 (18%), Positives = 109/331 (32%), Gaps = 47/331 (14%) Query: 289 KWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGI----TA 344 K+TL V G + S S D + + + KTISGH GI + Sbjct: 138 KFTLAGHTKAVSSVKFSPNGE-WLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 196 Query: 345 LTVNPLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHE 404 N L+S S D + W SS + + +++ + I Sbjct: 197 SDSNLLVSASDDKTLKIWDVSSGK------CLKTLKGHSNYVFCCNFNPQSNL--IVSGS 248 Query: 405 FGSQPKVASANNDGFTAVLTNDDDLLILQSFT--GDIIKSVRLNSPGSAVSLSQNYVAVG 462 F ++ L D + F G +I S + + Sbjct: 249 FDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKT 308 Query: 463 LEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREV 522 L + + V S++ SP+ YI A + + L+D S+ Sbjct: 309 LIDDDNPPV--------------------SFVKFSPNGKYILAATLDNTLKLWDY-SKGK 347 Query: 523 KTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNA 582 + H ++ I AN + +GS D ++I+++ + +I++ L Sbjct: 348 CLKTYTGHKNEKYCI-------FANFSVTGGKWIVSGSEDNLVYIWNL-QTKEIVQKLQG 399 Query: 583 HKDGVNNLLWETPSTLVSSGA---DACIKRW 610 H D V + +++S A D IK W Sbjct: 400 HTDVVISTACHPTENIIASAALENDKTIKLW 430 >6QX9-5O nrPDB Length = 357 Score = 241 bits (614), Expect = 8e-64, Method: Composition-based stats. Identities = 65/321 (20%), Positives = 128/321 (39%), Gaps = 33/321 (10%) Query: 50 DSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVK 109 S P++ +GH V KF P L S +++W D ++ + Sbjct: 53 SSLQAPIMLLSGHEGEVYC-CKFHP--NGSTLASAGFDRLILLWNVYGDCDNYAT----- 104 Query: 110 SEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDS--GNSLGEVSGHSQRINACH 167 + +G + ++ ++ +G L + WDS G + + GH+ +N+C+ Sbjct: 105 --LKGHSGAVMELHYNTDGSMLFSASTDK----TVAVWDSETGERVKRLKGHTSFVNSCY 158 Query: 168 LKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGS 227 + P T DDG+V + + A+ +T + V V F+ D+ + +I+ G Sbjct: 159 PARRGPQLVCTGSDDGTVKLWD---IRKKAAIQTF-QNTYQVLAVTFN-DTSDQIISGGI 213 Query: 228 DRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVT----T 283 D I +D + + + + V G + + + D T+RVWDV Sbjct: 214 DNDIKVWDLRQNKLTYTMRGHADSVTGLSLS---SEGSYLLSNAMDNTVRVWDVRPFAPK 270 Query: 284 SKCVQKWTLDKQQLGNQQVGVVATGNG-RIISLSLDGTLNFYELGHDEVLKTISGHNKGI 342 +CV+ + + + + +G +I + S D + ++ +L + GH I Sbjct: 271 ERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSI 330 Query: 343 TALTVNP----LISGSYDGRI 359 + +P +IS S D R+ Sbjct: 331 NEVAFHPDEPIIISASSDKRL 351 Score = 114 bits (285), Expect = 1e-25, Method: Composition-based stats. Identities = 53/335 (15%), Positives = 110/335 (32%), Gaps = 47/335 (14%) Query: 197 ASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEF--LKYIEDDQEPVQG 254 A V +F P+ G + + G DR I ++ G+ ++ V Sbjct: 57 APIMLLSGHEGEVYCCKFHPN-GSTLASAGFDRLILLWNV-YGDCDNYATLKGHSGAVME 114 Query: 255 GIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIIS 314 + D + D T+ VWD T + V++ G + + Sbjct: 115 LHYN---TDGSMLFSASTDKTVAVWDSETGERVKRLKGHTS--FVNSCYPARRGPQLVCT 169 Query: 315 LSLDGTLNFYELGHDEVLKTISGHNKGITALTVN----PLISGSYDGRIMEWSSSSMH-- 368 S DGT+ +++ ++T + A+T N +ISG D I W Sbjct: 170 GSDDGTVKLWDIRKKAAIQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLT 228 Query: 369 ---QDHSNLIVSL-DNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLT 424 + H++ + L +S+ S + D+T++V + A + + Sbjct: 229 YTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPF----------APKERCVKIFQ 278 Query: 425 NDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLK 484 + + S + A + +V V+ + + + L Sbjct: 279 GNVHNF----EKNLLRCSWSPDGSKIAAGSADRFV----------YVWDTTSRRILYKL- 323 Query: 485 TPLRA-KPSYISISPSETYIAAGDVMGKILLYDLQ 518 P A + ++ P E I + ++ + ++Q Sbjct: 324 -PGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357 Score = 105 bits (262), Expect = 5e-23, Method: Composition-based stats. Identities = 55/313 (17%), Positives = 106/313 (33%), Gaps = 31/313 (9%) Query: 250 EPVQGGIFALSW-LDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATG 308 +G ++ + + A+ G D I +W+V C TL ++ T Sbjct: 63 SGHEGEVYCCKFHPNGSTLASAGFDRLILLWNV-YGDCDNYATLKGHSGAVMELHY-NTD 120 Query: 309 NGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITA---LTVNP--LISGSYDGRIMEWS 363 + S S D T+ ++ E +K + GH + + P + +GS DG + W Sbjct: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180 Query: 364 SSSMHQDHSNLIVSLDNSKAQE-YSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAV 422 ++ + +++++DT + I + KV + T Sbjct: 181 IRKK--------AAIQTFQNTYQVLAVTFNDTS--DQIISGGIDNDIKVWDLRQNKLTYT 230 Query: 423 LTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFD 482 + D + S + + + + A + K+ V Sbjct: 231 MRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFA------PKERCVKIFQGNVHNF 284 Query: 483 LKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPA 542 K LR S SP + IAAG + ++D SR + + H IN +++ P Sbjct: 285 EKNLLRC-----SWSPDGSKIAAGSADRFVYVWDTTSRRI-LYKLPGHAGSINEVAFHPD 338 Query: 543 EKGANEEEIEEDL 555 E ++ L Sbjct: 339 EPIIISASSDKRL 351 Score = 67.6 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 43/306 (14%), Positives = 101/306 (33%), Gaps = 83/306 (27%) Query: 335 ISGHNKGITALTVNP----LISGSYDGRIMEW------SSSSMHQDHSNLIVSLD-NSKA 383 +SGH + +P L S +D I+ W + + + HS ++ L N+ Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121 Query: 384 QEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSV 443 S S D T + + S TG+ +K + Sbjct: 122 SMLFSASTDKT----------------------------------VAVWDSETGERVKRL 147 Query: 444 RLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRA----------KPSY 493 + ++ +V Q+ + + L + + Sbjct: 148 KGHTS---------FVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLA 198 Query: 494 ISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEE 553 ++ + + I +G + I ++DL+ ++ T H + +S E Sbjct: 199 VTFNDTSDQIISGGIDNDIKVWDLRQNKL-TYTMRGHADSVTGLSLSS----------EG 247 Query: 554 DLVATGSLDTNIFIYSVK------RPMKIIKA-LNAHKDGVNNLLWETPSTLVSSG-ADA 605 + + ++D + ++ V+ R +KI + ++ + + W + +++G AD Sbjct: 248 SYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADR 307 Query: 606 CIKRWN 611 + W+ Sbjct: 308 FVYVWD 313 Score = 52.2 bits (123), Expect = 7e-07, Method: Composition-based stats. Identities = 19/119 (15%), Positives = 46/119 (38%), Gaps = 13/119 (10%) Query: 496 ISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDL 555 P+ + +A+ ILL+++ + H+ + + + + + Sbjct: 74 FHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNT----------DGSM 123 Query: 556 VATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPS-TLVSSGA-DACIKRWNV 612 + + S D + ++ + +K L H VN+ LV +G+ D +K W++ Sbjct: 124 LFSASTDKTVAVWD-SETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI 181 Score = 46.5 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 26/117 (22%), Positives = 51/117 (43%), Gaps = 11/117 (9%) Query: 496 ISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDL 555 + + + + + ++D ++ E + R HTS +N S PA +G L Sbjct: 117 YNTDGSMLFSASTDKTVAVWDSETGE-RVKRLKGHTSFVN--SCYPARRGPQ-------L 166 Query: 556 VATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSGADACIKRWNV 612 V TGS D + ++ +++ I N ++ +T ++S G D IK W++ Sbjct: 167 VCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFN-DTSDQIISGGIDNDIKVWDL 222 >2H9P-A nrPDB Length = 329 Score = 239 bits (608), Expect = 4e-63, Method: Composition-based stats. Identities = 79/333 (23%), Positives = 131/333 (39%), Gaps = 39/333 (11%) Query: 49 GDSKVPPV-----VQFT--GHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKES 101 SK PV ++FT GH + V++VKFSP ++L S + +WG K Sbjct: 19 TQSKPTPVKPNYALKFTLAGH-TKAVSSVKFSP--NGEWLASSSADKLIKIWGAYDGK-- 73 Query: 102 NSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWD--SGNSLGEVSGH 159 + ISD++W + L + + WD SG L + GH Sbjct: 74 ------FEKTISGHKLGISDVAWSSDSNLLVSASDDK----TLKIWDVSSGKCLKTLKGH 123 Query: 160 SQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSG 219 S + C+ ++ D SV + K +T V V F+ D G Sbjct: 124 SNYVFCCNFNPQSN-LIVSGSFDESVRIWDVKTGKC---LKTLPAHSDPVSAVHFNRD-G 178 Query: 220 EFVITVGSDRKISCFDGKSGEFLKY-IEDDQEPVQGGIFALSWLDSQKFATVGADATIRV 278 +++ D +D SG+ LK I+DD PV F+ + + D T+++ Sbjct: 179 SLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS---PNGKYILAATLDNTLKL 235 Query: 279 WDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGH 338 WD + KC++ +T K + TG I+S S D + + L E+++ + GH Sbjct: 236 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 295 Query: 339 NKGITALTVNP----LISGS--YDGRIMEWSSS 365 + + +P + S + D I W S Sbjct: 296 TDVVISTACHPTENIIASAALENDKTIKLWKSD 328 Score = 116 bits (291), Expect = 2e-26, Method: Composition-based stats. Identities = 62/331 (18%), Positives = 109/331 (32%), Gaps = 47/331 (14%) Query: 289 KWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGI----TA 344 K+TL V G + S S D + + + KTISGH GI + Sbjct: 33 KFTLAGHTKAVSSVKFSPNGE-WLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 91 Query: 345 LTVNPLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHE 404 N L+S S D + W SS + + +++ + I Sbjct: 92 SDSNLLVSASDDKTLKIWDVSSGK------CLKTLKGHSNYVFCCNFNPQSNL--IVSGS 143 Query: 405 FGSQPKVASANNDGFTAVLTNDDDLLILQSFT--GDIIKSVRLNSPGSAVSLSQNYVAVG 462 F ++ L D + F G +I S + + Sbjct: 144 FDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKT 203 Query: 463 LEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREV 522 L + + V S++ SP+ YI A + + L+D S+ Sbjct: 204 LIDDDNPPV--------------------SFVKFSPNGKYILAATLDNTLKLWDY-SKGK 242 Query: 523 KTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNA 582 + H ++ I AN + +GS D ++I+++ + +I++ L Sbjct: 243 CLKTYTGHKNEKYCI-------FANFSVTGGKWIVSGSEDNLVYIWNL-QTKEIVQKLQG 294 Query: 583 HKDGVNNLLWETPSTLVSSGA---DACIKRW 610 H D V + +++S A D IK W Sbjct: 295 HTDVVISTACHPTENIIASAALENDKTIKLW 325 >6N9G-C nrPDB Length = 353 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 66/317 (20%), Positives = 132/317 (41%), Gaps = 34/317 (10%) Query: 59 FTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGP 118 GHG+ V+ K + + S + GKVIVW + ++V + P Sbjct: 59 LKGHGNKVLC---MDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAP 115 Query: 119 ISDISWDFEGRRLCVVGEGRDNFGVF--ISWDSGNSL----GEVSGHSQRINACHLKQSR 172 + G DN +++D ++ V+ H+ ++AC S Sbjct: 116 SG----------CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSD 165 Query: 173 PMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSP-DSGEFVITVGSDRKI 231 M+ +T DG+ + + ++ H G+ V ++ +P ++G ++ G D+K Sbjct: 166 -MQILTASGDGTCALWDVESGQL---LQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKA 221 Query: 232 SCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWT 291 +D +SG+ ++ E + V + S FA+ DAT R++D+ + V ++ Sbjct: 222 MVWDMRSGQCVQAFETHESDVNSVRYYPS---GDAFASGSDDATCRLYDLRADREVAIYS 278 Query: 292 LDKQQLGNQQVGVVATGNGRIISLSL-DGTLNFYELGHDEVLKTISGHNKGITALTVNP- 349 + G V + +GR++ D T+N +++ + + GH ++ L V+P Sbjct: 279 KESIIFGASSVDF--SLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPD 336 Query: 350 ---LISGSYDGRIMEWS 363 SGS+D + W+ Sbjct: 337 GTAFCSGSWDHTLRVWA 353 Score = 64.2 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 45/318 (14%), Positives = 105/318 (33%), Gaps = 56/318 (17%) Query: 330 EVLKTISGHNKGITALTVN----PLISGSYDGRIMEWSSSSMHQDHS-----NLIVSLDN 380 + +T+ GH + + ++S S DG+++ W S + +++H+ +++ Sbjct: 54 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAY 113 Query: 381 SKAQEYSSI------------SWDDTLKVNGITKHEFGSQPKVAS---ANNDGFTAVLTN 425 + + + ++D + K +++ N+D + Sbjct: 114 APSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASG 173 Query: 426 DDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKT 485 D + +G +++S + + L T F + + Sbjct: 174 DGTCALWDVESGQLLQSFHGHGADVLC--------LDLAPSETGNTFVSGGCDKKAMVWD 225 Query: 486 PL-----------RAKPSYISISPSETYIAAGDVMGKILLYDL-QSREVKTSRWAFHTSK 533 + + + PS A+G LYDL REV Sbjct: 226 MRSGQCVQAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFG 285 Query: 534 INAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWE 593 +++ + + + L+ G D I ++ V + ++ L H++ V+ L Sbjct: 286 ASSVDFSLSGR----------LLFAGYNDYTINVWDVLKGSRVSI-LFGHENRVSTLRVS 334 Query: 594 TPSTLVSSGA-DACIKRW 610 T SG+ D ++ W Sbjct: 335 PDGTAFCSGSWDHTLRVW 352 >6F3T-A nrPDB Length = 608 Score = 214 bits (543), Expect = 1e-55, Method: Composition-based stats. Identities = 71/365 (19%), Positives = 125/365 (34%), Gaps = 42/365 (11%) Query: 11 PPQPSTQRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTV 70 P P R L + I + VR D P + F ++ Sbjct: 227 PNAPPQNRIPLPELKDSDKLDKIMNMKETTKRVRLGPD----CLPSICFYTFLNAYQGLT 282 Query: 71 KFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRR 130 S + G V VW T K + + + Sbjct: 283 AVDVTDDSSLIAGGFADSTVRVWSVTPKK-------------------LRSVKQASDLSL 323 Query: 131 LCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQG 190 + + D + + + L + GHS + R ++ +DG+V + Sbjct: 324 IDKESD--DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYL-LSSSEDGTVRLWSL 380 Query: 191 PPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQE 250 F + H+ V D +FSP G + ++ G DR + + L+ Sbjct: 381 QTFTCLVGYKGHNYP---VWDTQFSP-YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLA 436 Query: 251 PVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNG 310 V F +S AT AD T+R+WDV CV+ +T K + + + NG Sbjct: 437 DVNCTRFH---PNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIH----SLTFSPNG 489 Query: 311 RII-SLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSS 365 R + + + DG + +++GH ++ + GH + +L + L SGS D + W + Sbjct: 490 RFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAI 549 Query: 366 SMHQD 370 +D Sbjct: 550 KAFED 554 Score = 135 bits (339), Expect = 5e-32, Method: Composition-based stats. Identities = 50/267 (18%), Positives = 107/267 (40%), Gaps = 27/267 (10%) Query: 148 DSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPF-------KFSASDR 200 DS G + + R+ + K+ +RS+ D S++ + K ++ + Sbjct: 289 DSSLIAGGFADSTVRVWSVTPKK---LRSVKQASDLSLIDKESDDVLERIMDEKTASELK 345 Query: 201 THHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALS 260 + V FSPD ++++ D + + ++ L + PV F+ Sbjct: 346 ILYGHSGPVYGASFSPDR-NYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 404 Query: 261 WLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGT 320 F + G D R+W + ++ + L + + + + S D T Sbjct: 405 ---GYYFVSGGHDRVARLWATDHYQPLRIFAGH---LADVNCTRFHPNSNYVATGSADRT 458 Query: 321 LNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSM-----HQDH 371 + +++ + ++ +GH I +LT +P L +G+ DGR++ W + H Sbjct: 459 VRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGH 518 Query: 372 SNLIVSLDNSKAQEYS-SISWDDTLKV 397 ++ + SL S+ E S S D+T+++ Sbjct: 519 TDTVCSLRFSRDGEILASGSMDNTVRL 545 Score = 101 bits (251), Expect = 1e-21, Method: Composition-based stats. Identities = 58/321 (18%), Positives = 111/321 (34%), Gaps = 70/321 (21%) Query: 263 DSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLN 322 DS A AD+T+RVW VT K + A+ I S D Sbjct: 289 DSSLIAGGFADSTVRVWSVTPKK--------------LRSVKQASDLSLIDKESDDVLER 334 Query: 323 FYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSS-----MHQDHSN 373 + LK + GH+ + + +P L+S S DG + WS + ++ H+ Sbjct: 335 IMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNY 394 Query: 374 LIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQ 433 + S Y ++ + D L+ Sbjct: 395 PVWDTQFSPYGYYF-------------VSGGHDRVARLWAT------------DHYQPLR 429 Query: 434 SFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDL--KTPLRAKP 491 F G + + + + NYVA G + L+ V K P+ + Sbjct: 430 IFAGHL-----ADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHS-- 482 Query: 492 SYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEI 551 ++ SP+ ++A G G++LL+D+ + HT + ++ + Sbjct: 483 --LTFSPNGRFLATGATDGRVLLWDI-GHGLMVGELKGHTDTVCSLRFS----------R 529 Query: 552 EEDLVATGSLDTNIFIYSVKR 572 + +++A+GS+D + ++ + Sbjct: 530 DGEILASGSMDNTVRLWDAIK 550 Score = 75.3 bits (183), Expect = 7e-14, Method: Composition-based stats. Identities = 44/331 (13%), Positives = 109/331 (32%), Gaps = 54/331 (16%) Query: 286 CVQKWTLDKQQLGNQQVGVVATGNGRIISLS-LDGTLNFYELGHDEVLKTISGHNKGITA 344 C + Q L V T + +I+ D T+ + + ++ + + Sbjct: 270 CFYTFLNAYQGLTAVDV----TDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLID 325 Query: 345 LTVNPLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHE 404 + ++ D + S + HS + S + Y S +D Sbjct: 326 KESDDVLERIMDEKTA--SELKILYGHSGPVYGASFSPDRNYLLSSSED----------- 372 Query: 405 FGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRL-NSPGSAVSLSQNYVAVGL 463 ++ S + + F+ V + + + + +Y + + Sbjct: 373 --GTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRI 430 Query: 464 EEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVK 523 G+ A + P+ Y+A G + L+D+ + Sbjct: 431 FAGHL--------------------ADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNC- 469 Query: 524 TSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAH 583 + H I+++++ P + +ATG+ D + ++ + + ++ L H Sbjct: 470 VRIFTGHKGPIHSLTFSPNGR----------FLATGATDGRVLLWDIGHGL-MVGELKGH 518 Query: 584 KDGVNNLLWETPSTLVSSGA-DACIKRWNVV 613 D V +L + +++SG+ D ++ W+ + Sbjct: 519 TDTVCSLRFSRDGEILASGSMDNTVRLWDAI 549 >6MZM-G nrPDB Length = 800 Score = 205 bits (520), Expect = 6e-53, Method: Composition-based stats. Identities = 52/222 (23%), Positives = 92/222 (41%), Gaps = 17/222 (7%) Query: 154 GEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVE 213 + GHS + R ++ +DG+V + F + H+ V D + Sbjct: 537 KILYGHSGPVYGASFSPDRNYL-LSSSEDGTVRLWSLQTFTCLVGYKGHNYP---VWDTQ 592 Query: 214 FSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGAD 273 FSP G + ++ G DR + + L+ V F +S AT AD Sbjct: 593 FSP-YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFH---PNSNYVATGSAD 648 Query: 274 ATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRII-SLSLDGTLNFYELGHDEVL 332 T+R+WDV CV+ +T K + + + NGR + + + DG + +++GH ++ Sbjct: 649 RTVRLWDVLNGNCVRIFTGHKGPIH----SLTFSPNGRFLATGATDGRVLLWDIGHGLMV 704 Query: 333 KTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQD 370 + GH + +L + L SGS D + W + +D Sbjct: 705 GELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFED 746 Score = 133 bits (334), Expect = 2e-31, Method: Composition-based stats. Identities = 40/206 (19%), Positives = 84/206 (40%), Gaps = 17/206 (8%) Query: 202 HHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSW 261 + V FSPD ++++ D + + ++ L + PV F+ Sbjct: 539 LYGHSGPVYGASFSPDR-NYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY- 596 Query: 262 LDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTL 321 F + G D R+W + ++ + L + + + + S D T+ Sbjct: 597 --GYYFVSGGHDRVARLWATDHYQPLRIFAGH---LADVNCTRFHPNSNYVATGSADRTV 651 Query: 322 NFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSM-----HQDHS 372 +++ + ++ +GH I +LT +P L +G+ DGR++ W + H+ Sbjct: 652 RLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHT 711 Query: 373 NLIVSLDNSKAQEYS-SISWDDTLKV 397 + + SL S+ E S S D+T+++ Sbjct: 712 DTVCSLRFSRDGEILASGSMDNTVRL 737 Score = 125 bits (312), Expect = 9e-29, Method: Composition-based stats. Identities = 45/223 (20%), Positives = 74/223 (33%), Gaps = 21/223 (9%) Query: 58 QFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAG 117 GH V FSP + YL S E G V +W ++ Sbjct: 538 ILYGHSGPVY-GASFSPDRN--YLLSSSEDGTVRLWSLQ--------TFTCLVGYKGHNY 586 Query: 118 PISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSM 177 P+ D + G G D + D L +GH +N + Sbjct: 587 PVWDTQFSPYGYYFVS--GGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNY-VA 643 Query: 178 TVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGK 237 T D +V + R + + FSP+ G F+ T +D ++ +D Sbjct: 644 TGSADRTVRLWDVLNGNC---VRIFTGHKGPIHSLTFSPN-GRFLATGATDGRVLLWDIG 699 Query: 238 SGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWD 280 G + ++ + V F+ D + A+ D T+R+WD Sbjct: 700 HGLMVGELKGHTDTVCSLRFS---RDGEILASGSMDNTVRLWD 739 Score = 85.7 bits (210), Expect = 5e-17, Method: Composition-based stats. Identities = 41/251 (16%), Positives = 89/251 (35%), Gaps = 56/251 (22%) Query: 333 KTISGHNKGITALTVNP----LISGSYDGRIMEWSSSS-----MHQDHSNLIVSLDNSKA 383 K + GH+ + + +P L+S S DG + WS + ++ H+ + S Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 596 Query: 384 QEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSV 443 Y ++ + D L+ F G + Sbjct: 597 GYYF-------------VSGGHDRVARLWAT------------DHYQPLRIFAGHL---- 627 Query: 444 RLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDL--KTPLRAKPSYISISPSET 501 + + + NYVA G + L+ V K P+ + ++ SP+ Sbjct: 628 -ADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHS----LTFSPNGR 682 Query: 502 YIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSL 561 ++A G G++LL+D+ + HT + ++ + + +++A+GS+ Sbjct: 683 FLATGATDGRVLLWDI-GHGLMVGELKGHTDTVCSLRFS----------RDGEILASGSM 731 Query: 562 DTNIFIYSVKR 572 D + ++ + Sbjct: 732 DNTVRLWDAIK 742 Score = 66.1 bits (159), Expect = 5e-11, Method: Composition-based stats. Identities = 34/194 (17%), Positives = 70/194 (36%), Gaps = 34/194 (17%) Query: 442 SVRLNSPGSAVSLSQNYVAVGLEEGNT----------IQVFKLSDLEVSFDLK-----TP 486 S + SL VG + N F + L P Sbjct: 560 SSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQP 619 Query: 487 LR------AKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWK 540 LR A + P+ Y+A G + L+D+ + + H I+++++ Sbjct: 620 LRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNC-VRIFTGHKGPIHSLTFS 678 Query: 541 PAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVS 600 P + +ATG+ D + ++ + + ++ L H D V +L + +++ Sbjct: 679 PNGR----------FLATGATDGRVLLWDIGHGL-MVGELKGHTDTVCSLRFSRDGEILA 727 Query: 601 SGA-DACIKRWNVV 613 SG+ D ++ W+ + Sbjct: 728 SGSMDNTVRLWDAI 741 >4V6W-Ag nrPDB Length = 318 Score = 198 bits (502), Expect = 7e-51, Method: Composition-based stats. Identities = 47/262 (17%), Positives = 108/262 (41%), Gaps = 17/262 (6%) Query: 148 DSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQG---PPFKFSASDRTHHK 204 ++ G + GH+ + P ++ D +++ ++ + + + Sbjct: 3 ETLQLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYG 62 Query: 205 QGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDS 264 F+ DV S D G + ++ D+ + +D +G+ + E + V F+ D+ Sbjct: 63 HSHFISDVVLSSD-GNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFS---ADN 118 Query: 265 QKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVAT-GNGRIISLSLDGTLNF 323 ++ + D TI++W+ T ++C D V N I+S D T+ Sbjct: 119 RQIVSGSRDKTIKLWN-TLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKV 177 Query: 324 YELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQ----DHSNLI 375 + L + ++ GHN + +TV+P SG D + + W + +H+++I Sbjct: 178 WNLANCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLEHNDII 237 Query: 376 VSLDNSKAQEYSSISWDDTLKV 397 +L S + + +++ ++K+ Sbjct: 238 NALCFSPNRYWLCVAYGPSIKI 259 Score = 115 bits (287), Expect = 7e-26, Method: Composition-based stats. Identities = 49/323 (15%), Positives = 110/323 (34%), Gaps = 35/323 (10%) Query: 59 FTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGP 118 GH V T + +P K + S +IVW T D+++N + + Sbjct: 11 LIGHNGWV-TQIATNP-KDPDTIISASRDKTLIVWKLTRDEDTN--YGYPQKRLYGHSHF 66 Query: 119 ISDISWDFEGRRLCVVGEGRDNFGVFISWD--SGNSLGEVSGHSQRINACHLKQSRPMRS 176 ISD+ +G + WD +G + GH++ + + + Sbjct: 67 ISDVVLSSDGNYALSGSWDQ----TLRLWDLAAGKTTRRFEGHTKDVLSVAFSA-DNRQI 121 Query: 177 MTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPD-SGEFVITVGSDRKISCFD 235 ++ D ++ + + + + +V V FSP+ S +++ G DR + ++ Sbjct: 122 VSGSRDKTIKLW-NTLAECKFTIQE-DGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWN 179 Query: 236 GKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQ 295 + + + + D + G D+ +WD+ K + +TL+ Sbjct: 180 LANCKLKNNHHGHNGYLNTVTVS---PDGSLCTSGGKDSKALLWDLNDGKNL--YTLEHN 234 Query: 296 QLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHN-------------KGI 342 + N + N + ++ ++ ++L + ++ + Sbjct: 235 DIINALC---FSPNRYWLCVAYGPSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLA 291 Query: 343 TALTVNPLISGSYDGRIMEWSSS 365 + L +G D I W S Sbjct: 292 WSTDGQTLFAGYSDNTIRVWQVS 314 Score = 100 bits (249), Expect = 2e-21, Method: Composition-based stats. Identities = 48/291 (16%), Positives = 104/291 (35%), Gaps = 34/291 (11%) Query: 47 DDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEV 106 D+ + P + GH S ++ V S Y SG + +W K + Sbjct: 48 DEDTNYGYPQKRLYGH-SHFISDVVLS--SDGNYALSGSWDQTLRLWDLAAGKTT----- 99 Query: 107 NVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDS-GNSLGEVS--GHSQRI 163 F+ + +++ + R++ + W++ + GH+ + Sbjct: 100 ---RRFEGHTKDVLSVAFSADNRQIVSGSRDK----TIKLWNTLAECKFTIQEDGHTDWV 152 Query: 164 NACHLKQS-RPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFV 222 + + ++ G D +V + K HH ++ V SPD G Sbjct: 153 SCVRFSPNHSNPIIVSCGWDRTVKVWNLANCKLK---NNHHGHNGYLNTVTVSPD-GSLC 208 Query: 223 ITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVT 282 + G D K +D G+ L +E I AL + ++ + V +I++WD+ Sbjct: 209 TSGGKDSKALLWDLNDGKNLYTLE-----HNDIINALCFSPNRYWLCVAYGPSIKIWDLA 263 Query: 283 TSKCVQKWTLD-----KQQLGNQQVGVVATGNGRIISLSL-DGTLNFYELG 327 K V++ + + Q + + + +G+ + D T+ +++ Sbjct: 264 CKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTLFAGYSDNTIRVWQVS 314 Score = 78.4 bits (191), Expect = 8e-15, Method: Composition-based stats. Identities = 43/250 (17%), Positives = 80/250 (32%), Gaps = 29/250 (11%) Query: 43 VRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESN 102 +R D K +F GH V+ +V FS ++ + SG + +W + + Sbjct: 88 LRLWDLAAGKTT--RRFEGHTKDVL-SVAFS--ADNRQIVSGSRDKTIKLWNTLAECKFT 142 Query: 103 SVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNS--LGEVSGHS 160 E + S + + G R W+ N GH+ Sbjct: 143 IQEDGHTDWVSCVR-----FSPNHSNPIIVSCGWDR----TVKVWNLANCKLKNNHHGHN 193 Query: 161 QRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGE 220 +N + + G D + + K + + + FSP+ Sbjct: 194 GYLNTVTVSPDG-SLCTSGGKDSKALLWDLNDGKNLYTLE----HNDIINALCFSPNR-- 246 Query: 221 FVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGI-----FALSWL-DSQKFATVGADA 274 + + V I +D + ++ + + +L+W D Q +D Sbjct: 247 YWLCVAYGPSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTLFAGYSDN 306 Query: 275 TIRVWDVTTS 284 TIRVW V+ S Sbjct: 307 TIRVWQVSVS 316 Score = 65.7 bits (158), Expect = 6e-11, Method: Composition-based stats. Identities = 58/328 (17%), Positives = 112/328 (34%), Gaps = 65/328 (19%) Query: 330 EVLKTISGHNKGITALTVNP-----LISGSYDGRIMEW------SSSSMHQ-----DHSN 373 ++ T+ GHN +T + NP +IS S D ++ W ++ + HS+ Sbjct: 6 QLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSH 65 Query: 374 LIVS-LDNSKAQEYSSISWDDTLKV-----NGITKHEFGSQPKVASA---NNDGFTAVLT 424 I + +S S SWD TL++ T+ G V S ++ + Sbjct: 66 FISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQIVSGS 125 Query: 425 NDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLK 484 D + + + + +++ + VS V ++ + + + + Sbjct: 126 RDKTIKLWNTL-AECKFTIQEDGHTDWVSC------VRFSPNHSNPIIVSCGWDRTVKVW 178 Query: 485 TPLRAK-----------PSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSK 533 K + +++SP + +G K LL+DL + K H Sbjct: 179 NLANCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLN--DGKNLYTLEHNDI 236 Query: 534 INAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVK--------RPMKIIKALNAHKD 585 INA+ + P +I I+ + RP + A + Sbjct: 237 INALCFSPNRYWLCVAYGP-----------SIKIWDLACKKTVEELRPEVVSPTSKADQP 285 Query: 586 GVNNLLWETPSTLVSSG-ADACIKRWNV 612 +L W T + +G +D I+ W V Sbjct: 286 QCLSLAWSTDGQTLFAGYSDNTIRVWQV 313 >5FVM-C nrPDB Length = 303 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 66/323 (20%), Positives = 119/323 (36%), Gaps = 61/323 (18%) Query: 29 TTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESG 88 T++ VR D + PV F GH +V T++ F + ++++ S E G Sbjct: 41 TSDKKYLAAAGHLHVRLYDIRSNNPNPVSSFEGHKGNV-TSIAFQ--QENRWMVSSSEDG 97 Query: 89 KVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWD 148 + VW D S SV+ N K P+++++ N G IS D Sbjct: 98 TIKVW----DVRSPSVQRNYKHN-----APVNEVA-------------IHPNQGELISCD 135 Query: 149 S-GNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGS 207 GN G +Q N + + P++S++V DGS++ HH S Sbjct: 136 QDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNKGNCYVWRMPHHTDAS 195 Query: 208 FVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKF 267 + V + + + + + D + Sbjct: 196 TLEPVT------------------------------KFKSHTKYITRVLLS---ADVKNL 222 Query: 268 ATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELG 327 AT AD T RVW++ + ++ TLD Q A + +++ D + ++L Sbjct: 223 ATCSADHTARVWNIEDNYQLET-TLDGHQRWVWDCAFSA-DSAYLVTACSDHYVRLWDLS 280 Query: 328 HDEVLKTISGHNKGITALTVNPL 350 E+++ GH+KG + +N + Sbjct: 281 TSEIVRQYGGHHKGAVCVALNDV 303 Score = 92.7 bits (228), Expect = 4e-19, Method: Composition-based stats. Identities = 57/324 (17%), Positives = 121/324 (37%), Gaps = 36/324 (11%) Query: 222 VITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDV 281 + + G D I ++ +G + I+ V D + A G +R++D+ Sbjct: 5 LASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEIT---SDKKYLAAAGHLH-VRLYDI 60 Query: 282 TTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKG 341 ++ + + + + N ++S S DGT+ +++ V + HN Sbjct: 61 RSNNPNPVSSFEGHKGNVTSIAFQ-QENRWMVSSSEDGTIKVWDVRSPSVQRNYK-HNAP 118 Query: 342 ITALTVNP----LISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKV 397 + + ++P LIS DG I W +N + DN+ Q S++ D ++ V Sbjct: 119 VNEVAIHPNQGELISCDQDGNIRIWDL--GENQCTNQLTPEDNTPLQS-LSVASDGSMLV 175 Query: 398 NGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQN 457 G K V + + L + + +S T I + +S Sbjct: 176 AGNNKG----NCYVWRMPHHTDASTL---EPVTKFKSHTKYITR--------VLLSADVK 220 Query: 458 YVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYI---SISPSETYIAAGDVMGKILL 514 +A + +T +V+ + D ++ L+T L ++ + S Y+ + L Sbjct: 221 NLATCSAD-HTARVWNIED---NYQLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRL 276 Query: 515 YDLQSREVKTSRWAFHTSKINAIS 538 +DL + E+ ++ H ++ Sbjct: 277 WDLSTSEI-VRQYGGHHKGAVCVA 299 Score = 91.1 bits (224), Expect = 1e-18, Method: Composition-based stats. Identities = 51/302 (16%), Positives = 110/302 (36%), Gaps = 40/302 (13%) Query: 178 TVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGK 237 + G D ++ F++ RT S V +E + D + +D + Sbjct: 7 SAGYDHTIRFWEALT---GVCSRTIQHADSQVNRLEITSDKKYLAAAGHL--HVRLYDIR 61 Query: 238 SG--EFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQ 295 S + E + V F +++ + D TI+VWDV + + + K Sbjct: 62 SNNPNPVSSFEGHKGNVTSIAF---QQENRWMVSSSEDGTIKVWDVRSPSVQRNY---KH 115 Query: 296 QLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKG-ITALTV----NPL 350 +V + G +IS DG + ++LG ++ ++ + + +L+V + L Sbjct: 116 NAPVNEVAIHPN-QGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSML 174 Query: 351 ISGSYDGRIMEW-----------SSSSMHQDHSNLIVS-LDNSKAQEYSSISWDDTLKVN 398 ++G+ G W + + H+ I L ++ + ++ S D T +V Sbjct: 175 VAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVW 234 Query: 399 GITKHEF------GSQPKVAS---ANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPG 449 I + G Q V + + + +D + + T +I++ + G Sbjct: 235 NIEDNYQLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLSTSEIVRQYGGHHKG 294 Query: 450 SA 451 + Sbjct: 295 AV 296 Score = 68.4 bits (165), Expect = 8e-12, Method: Composition-based stats. Identities = 44/286 (15%), Positives = 113/286 (39%), Gaps = 34/286 (11%) Query: 350 LISGSYDGRIMEWSSSSM-----HQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHE 404 L S YD I W + + Q + + L+ + ++Y + + +++ I + Sbjct: 5 LASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGHLHVRLYDIRSNN 64 Query: 405 F-------GSQPKVASAN---NDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPG--SAV 452 G + V S + + + D + + + + ++ + N+P A+ Sbjct: 65 PNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYKHNAPVNEVAI 124 Query: 453 SLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKI 512 +Q + ++GN I+++ L + + + L +S++ + + AG+ G Sbjct: 125 HPNQGELISCDQDGN-IRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNKGNC 183 Query: 513 LLYDL-----QSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFI 567 ++ + S +++ HT I + K +AT S D + Sbjct: 184 YVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKN----------LATCSADHTARV 233 Query: 568 YSVKRPMKIIKALNAHKDGVNNLLWETPST-LVSSGADACIKRWNV 612 ++++ ++ L+ H+ V + + S LV++ +D ++ W++ Sbjct: 234 WNIEDNYQLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDL 279 >6G51-g nrPDB Length = 317 Score = 191 bits (484), Expect = 1e-48, Method: Composition-based stats. Identities = 48/261 (18%), Positives = 98/261 (37%), Gaps = 16/261 (6%) Query: 148 DSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQG--PPFKFSASDRTHHKQ 205 + G + GH+ + P ++ D +++ ++ + R Sbjct: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH 62 Query: 206 GSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQ 265 FV DV S D G+F ++ D + +D +G + + V F+ D++ Sbjct: 63 SHFVSDVVISSD-GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFS---SDNR 118 Query: 266 KFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVA-TGNGRIISLSLDGTLNFY 324 + + D TI++W+ T C + V + N I+S D + + Sbjct: 119 QIVSGSRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW 177 Query: 325 ELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQ----DHSNLIV 376 L + ++ GH + +TV+P SG DG+ M W + D ++I Sbjct: 178 NLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIIN 237 Query: 377 SLDNSKAQEYSSISWDDTLKV 397 +L S + + + ++K+ Sbjct: 238 ALCFSPNRYWLCAATGPSIKI 258 Score = 99.2 bits (245), Expect = 5e-21, Method: Composition-based stats. Identities = 47/292 (16%), Positives = 96/292 (32%), Gaps = 34/292 (11%) Query: 48 DGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVN 107 D + P GH S V+ V S Q+ SG G + +W T Sbjct: 48 DETNYGIPQRALRGH-SHFVSDVVIS--SDGQFALSGSWDGTLRLWDLT--------TGT 96 Query: 108 VKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDS-GNSLGEV--SGHSQRIN 164 F + +++ + R++ + W++ G V HS+ ++ Sbjct: 97 TTRRFVGHTKDVLSVAFSSDNRQIVSGSRDK----TIKLWNTLGVCKYTVQDESHSEWVS 152 Query: 165 ACHLKQ-SRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVI 223 S ++ G D V + K H ++ V SPD G Sbjct: 153 CVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT---NHIGHTGYLNTVTVSPD-GSLCA 208 Query: 224 TVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTT 283 + G D + +D G+ L ++ I AL + ++ + +I++WD+ Sbjct: 209 SGGKDGQAMLWDLNEGKHLYTLDG-----GDIINALCFSPNRYWLCAATGPSIKIWDLEG 263 Query: 284 SKCVQKWTLDKQQLGN-----QQVGVVATGNGRIISLS-LDGTLNFYELGHD 329 V + + + Q + + +G+ + D + +++ Sbjct: 264 KIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 Score = 71.1 bits (172), Expect = 1e-12, Method: Composition-based stats. Identities = 39/248 (15%), Positives = 80/248 (32%), Gaps = 25/248 (10%) Query: 43 VRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESN 102 +R D +F GH V+ +V FS ++ + SG + +W + Sbjct: 87 LRLWDLTTGTTT--RRFVGHTKDVL-SVAFS--SDNRQIVSGSRDKTIKLWNTLGVCK-- 139 Query: 103 SVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQR 162 + + + +S + + +V G D + + GH+ Sbjct: 140 -----YTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGY 194 Query: 163 INACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFV 222 +N + + G DG + + K + G + + FSP+ + Sbjct: 195 LNTVTVSPDG-SLCASGGKDGQAMLWDLNEGKHLYTLDG----GDIINALCFSPNR--YW 247 Query: 223 ITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGI-----FALSW-LDSQKFATVGADATI 276 + + I +D + + ++ + +L+W D Q D + Sbjct: 248 LCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLV 307 Query: 277 RVWDVTTS 284 RVW VT Sbjct: 308 RVWQVTIG 315 Score = 57.6 bits (137), Expect = 2e-08, Method: Composition-based stats. Identities = 52/300 (17%), Positives = 102/300 (34%), Gaps = 63/300 (21%) Query: 331 VLKTISGHNKGITALTVNP-----LISGSYDGRIMEWS----------SSSMHQDHSNLI 375 + T+ GHN +T + P ++S S D I+ W + HS+ + Sbjct: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFV 66 Query: 376 VSLD-NSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQS 434 + +S Q S SWD TL++ T ++ + Sbjct: 67 SDVVISSDGQFALSGSWDGTLRL--------------WDLTTGTTTRRFVGHTKDVLSVA 112 Query: 435 FTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYI 494 F+ D N + S + NT+ V K + + S S + Sbjct: 113 FSSD-------NRQIVSGSRDKTIKL-----WNTLGVCKYTVQDESHSEW------VSCV 154 Query: 495 SISPSET--YIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIE 552 SP+ + I + + +++L + ++KT+ HT +N ++ P + Sbjct: 155 RFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNH-IGHTGYLNTVTVSP----------D 203 Query: 553 EDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSGADACIKRWNV 612 L A+G D ++ + + D +N L + + + IK W++ Sbjct: 204 GSLCASGGKDGQAMLWDLNEGKHLYTLDGG--DIINALCFSPNRYWLCAATGPSIKIWDL 261 Score = 51.5 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 30/183 (16%), Positives = 58/183 (31%), Gaps = 20/183 (10%) Query: 64 SSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDIS 123 S V+ V+FSP + + S V VW K +K+ G ++ ++ Sbjct: 148 SEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK--------LKTNHIGHTGYLNTVT 199 Query: 124 WDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDG 183 +G G+D + + G L + G INA +R + Sbjct: 200 VSPDGSLC--ASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPNR--YWLCAATGP 254 Query: 184 SVVFYQ------GPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGK 237 S+ + K + + + +S D G+ + +D + + Sbjct: 255 SIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSAD-GQTLFAGYTDNLVRVWQVT 313 Query: 238 SGE 240 G Sbjct: 314 IGT 316 Score = 36.4 bits (82), Expect = 0.033, Method: Composition-based stats. Identities = 18/116 (15%), Positives = 41/116 (35%), Gaps = 16/116 (13%) Query: 503 IAAGDVMGKILLYDLQSREVKTS----RWAFHTSKINAISWKPAEKGANEEEIEEDLVAT 558 I + I+++ L E H+ ++ + + A + Sbjct: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFA----------LS 80 Query: 559 GSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSGA-DACIKRWNVV 613 GS D + ++ + + H V ++ + + + + SG+ D IK WN + Sbjct: 81 GSWDGTLRLWDLT-TGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL 135 >3DM0-A nrPDB Length = 694 Score = 191 bits (484), Expect = 1e-48, Method: Composition-based stats. Identities = 49/257 (19%), Positives = 108/257 (42%), Gaps = 18/257 (7%) Query: 154 GEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQ--GPPFKFSASDRTHHKQGSFVRD 211 G + H+ + A ++ D S++ ++ + + R FV D Sbjct: 376 GTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVED 435 Query: 212 VEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVG 271 V S D G+F ++ D ++ +D +G + + V F+L D+++ + Sbjct: 436 VVLSSD-GQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSL---DNRQIVSAS 491 Query: 272 ADATIRVWDVTTSKCVQKWT--LDKQQLGNQQVGVVA-TGNGRIISLSLDGTLNFYELGH 328 D TI++W+ T +C + + + V T I+S S D T+ + L + Sbjct: 492 RDRTIKLWN-TLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSN 550 Query: 329 DEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQ----DHSNLIVSLDN 380 ++ T++GH ++ + V+P SG DG ++ W + + + +++I +L Sbjct: 551 CKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEANSVIHALCF 610 Query: 381 SKAQEYSSISWDDTLKV 397 S + + + + +K+ Sbjct: 611 SPNRYWLCAATEHGIKI 627 Score = 114 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 48/293 (16%), Positives = 100/293 (34%), Gaps = 48/293 (16%) Query: 58 QFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAG 117 + TGH V V S Q+ SG G++ +W + F Sbjct: 425 RLTGHSHFVEDVVLSS---DGQFALSGSWDGELRLWDLAAGVST--------RRFVGHTK 473 Query: 118 PISDISWDFEGRRLCVVGEGRDNFGVFISWDS-GNSLGEV----SGHSQRINACHLKQSR 172 + +++ + R++ R W++ G + GH ++ + Sbjct: 474 DVLSVAFSLDNRQIVSASRDR----TIKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNT 529 Query: 173 PM-RSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKI 231 ++ D +V + K ++ H +V V SPD G + G D + Sbjct: 530 LQPTIVSASWDKTVKVWNLSNCKLRSTLAGHTG---YVSTVAVSPD-GSLCASGGKDGVV 585 Query: 232 SCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWT 291 +D G+ L +E + I AL + ++ + + I++WD+ + V+ Sbjct: 586 LLWDLAEGKKLYSLEAN-----SVIHALCFSPNRYWLCAATEHGIKIWDLESKSIVEDLK 640 Query: 292 LD-----------------KQQLGNQQVGVVATGNGRIISLSLDGTLNFYELG 327 +D ++ + + A G+ + S DG + + +G Sbjct: 641 VDLKAEAEKADNSGPAATKRKVIYCTSLNWSADGS-TLFSGYTDGVIRVWGIG 692 Score = 71.1 bits (172), Expect = 1e-12, Method: Composition-based stats. Identities = 63/360 (17%), Positives = 123/360 (34%), Gaps = 75/360 (20%) Query: 287 VQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGH-----DEVLKTISGHNKG 341 V K T+ + I+S S D ++ ++L + ++GH+ Sbjct: 373 VLKGTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHF 432 Query: 342 ITALTVNP----LISGSYDGRIMEWSSSSM-----HQDHSNLIVSLDNS-KAQEYSSISW 391 + + ++ +SGS+DG + W ++ H+ ++S+ S ++ S S Sbjct: 433 VEDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSASR 492 Query: 392 DDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSA 451 D T+K+ + G S +G ++ + + I S + Sbjct: 493 DRTIKL----WNTLGECKYTISEGGEGHRDWVSC---VRFSPNTLQPTIVSASWDKTVKV 545 Query: 452 VSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGK 511 +LS + L G+T V S +++SP + A+G G Sbjct: 546 WNLSNCKLRSTLA-GHTGYV--------------------STVAVSPDGSLCASGGKDGV 584 Query: 512 ILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVK 571 +LL+DL E K S I+A+ + P + + I I+ ++ Sbjct: 585 VLLWDLA--EGKKLYSLEANSVIHALCFSP-----------NRYWLCAATEHGIKIWDLE 631 Query: 572 RPM---KIIKALNAHKDGVNN---------------LLWETPSTLVSSG-ADACIKRWNV 612 + L A + +N L W + + SG D I+ W + Sbjct: 632 SKSIVEDLKVDLKAEAEKADNSGPAATKRKVIYCTSLNWSADGSTLFSGYTDGVIRVWGI 691 Score = 41.1 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 21/122 (17%), Positives = 44/122 (36%), Gaps = 16/122 (13%) Query: 499 SETYIAAGDVMGKILLYDLQSRE----VKTSRWAFHTSKINAISWKPAEKGANEEEIEED 554 + I + I+L+ L + V R H+ + + + A Sbjct: 394 NADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVLSSDGQFA-------- 445 Query: 555 LVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPST-LVSSGADACIKRWNVV 613 +GS D + ++ + + + H V ++ + + +VS+ D IK WN + Sbjct: 446 --LSGSWDGELRLWDLAAGVS-TRRFVGHTKDVLSVAFSLDNRQIVSASRDRTIKLWNTL 502 Query: 614 LE 615 E Sbjct: 503 GE 504 >6HHQ-h nrPDB Length = 319 Score = 180 bits (456), Expect = 2e-45, Method: Composition-based stats. Identities = 53/260 (20%), Positives = 102/260 (39%), Gaps = 22/260 (8%) Query: 153 LGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQ--GPPFKFSASDRTHHKQGSFVR 210 G + GH+ + + +P ++ D +++ ++ G KF R+ V+ Sbjct: 10 RGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQ 69 Query: 211 DVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATV 270 D + D G + ++ D+ + +D +GE + + V + + Sbjct: 70 DCTLTAD-GAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDID---KKASMIISG 125 Query: 271 GADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVAT-----GNGRIISLSLDGTLNFYE 325 D TI+VW + +C+ TL QV VV + IIS D + + Sbjct: 126 SRDKTIKVWTIK-GQCLA--TLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWN 182 Query: 326 LGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQDHS----NLIVS 377 L ++ GHN I LT +P + S DG IM W+ ++ ++ + + S Sbjct: 183 LNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQDEVFS 242 Query: 378 LDNSKAQEYSSISWDDTLKV 397 L S + + + + +KV Sbjct: 243 LAFSPNRYWLAAATATGIKV 262 Score = 66.5 bits (160), Expect = 3e-11, Method: Composition-based stats. Identities = 59/335 (17%), Positives = 118/335 (35%), Gaps = 42/335 (12%) Query: 291 TLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEV-----LKTISGHNKGITAL 345 TL+ + A ++S S D TL ++L D+ +++ GH+ + Sbjct: 12 TLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDC 71 Query: 346 TVNP----LISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGIT 401 T+ +S S+D + W ++ + + S+ D K + I Sbjct: 72 TLTADGAYALSASWDKTLRLWDVATGETYQRFV------GHKSDVMSVDIDK--KASMII 123 Query: 402 KHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAV 461 KV + A L +D + ++ + + + + + N V Sbjct: 124 SGSRDKTIKVWTI-KGQCLATLLGHNDWV----SQVRVVPNEKADDDSVTIISAGNDKMV 178 Query: 462 GLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSRE 521 N Q+ E F + + ++ SP T IA+ G+I+L++L +++ Sbjct: 179 KAWNLNQFQI------EADFIGHN---SNINTLTASPDGTLIASAGKDGEIMLWNLAAKK 229 Query: 522 VKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRP--MKIIKA 579 + A ++ ++++ P V SLD + + RP KA Sbjct: 230 AMYTLSA--QDEVFSLAFSPNRYWLAAATATGIKVF--SLDPQYLVDDL-RPEFAGYSKA 284 Query: 580 LNAHKDGVNNLLWETPSTLVSSG-ADACIKRWNVV 613 H +L W + +G D I+ W V+ Sbjct: 285 AEPH---AVSLAWSADGQTLFAGYTDNVIRVWQVM 316 Score = 63.0 bits (151), Expect = 4e-10, Method: Composition-based stats. Identities = 44/233 (18%), Positives = 76/233 (32%), Gaps = 20/233 (8%) Query: 58 QFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAG 117 +F GH S V++ K + + SG + VW + + N QV Sbjct: 102 RFVGHKSDVMSV---DIDKKASMIISGSRDKTIKVWTIKGQCLATLLGHN-DWVSQVRVV 157 Query: 118 PISDISWDFEGRRLCVVGEGRDNFGVFISWDSG--NSLGEVSGHSQRINACHLKQSRPMR 175 P + D + + G + + +W+ + GH+ IN Sbjct: 158 P--NEKADDDSVTIISAGNDK----MVKAWNLNQFQIEADFIGHNSNINTLTASPDG-TL 210 Query: 176 SMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFD 235 + G DG ++ + K + T Q V + FSP+ + K+ D Sbjct: 211 IASAGKDGEIMLWNLAAKK---AMYTLSAQ-DEVFSLAFSPNRYWLAAATATGIKVFSLD 266 Query: 236 GKSGEFLKY--IEDDQEPVQGGIFALSW-LDSQKFATVGADATIRVWDVTTSK 285 + + + +L+W D Q D IRVW V T+ Sbjct: 267 PQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQVMTAN 319 >6QX9-4B nrPDB Length = 522 Score = 178 bits (451), Expect = 6e-45, Method: Composition-based stats. Identities = 70/301 (23%), Positives = 113/301 (37%), Gaps = 36/301 (11%) Query: 118 PISDISWDFEGRRLCVVGEGRDNFGVFISWD--SGNSLGEVSGHSQRINACHLKQS---- 171 PIS + + L G+ W N L + GH+ + A Sbjct: 233 PISYCHFSPNSKMLATAC----WSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288 Query: 172 ---RPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSD 228 + + + DGSV + + A H + V V + P SG F+ T D Sbjct: 289 LDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVR---VARVMWHP-SGRFLGTTCYD 344 Query: 229 RKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQ 288 R +D ++ E + + E V F D T G DA RVWD+ T +C+ Sbjct: 345 RSWRLWDLEAQEEILHQEGHSMGVYDIAFH---QDGSLAGTGGLDAFGRVWDLRTGRCIM 401 Query: 289 KWTLDKQQLGNQQVGVVATGNGRII-SLSLDGTLNFYELGHDEVLKTISGHNKGITALTV 347 +++ G+ + NG I + S D T ++L + TI H +T + Sbjct: 402 FLEGHLKEIY----GINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKF 457 Query: 348 NP-----LISGSYDGRIME-----WSSSSMHQDHSNLIVSLD-NSKAQEYSSISWDDTLK 396 P L++G+YD WS H ++ LD +S Q ++ S+D T K Sbjct: 458 EPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFK 517 Query: 397 V 397 + Sbjct: 518 L 518 Score = 111 bits (276), Expect = 1e-24, Method: Composition-based stats. Identities = 50/257 (19%), Positives = 84/257 (32%), Gaps = 25/257 (9%) Query: 24 LSYDPTTNAIAYPCGK-SAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLC 82 +S DP +A S + LD + PV GH V + ++L Sbjct: 287 VSLDPKDVNLASCAADGSVKLWSLDSDE----PVADIEGHTVRV---ARVMWHPSGRFLG 339 Query: 83 SGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFG 142 + +W +E E + + DI++ +G G D FG Sbjct: 340 TTCYDRSWRLWDLEAQEEILHQE--------GHSMGVYDIAFHQDGSL--AGTGGLDAFG 389 Query: 143 VFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTH 202 +G + + GH + I + + T D + + + T Sbjct: 390 RVWDLRTGRCIMFLEGHLKEIYGINFSPNG-YHIATGSGDNTCKVWDLRQRRC---VYTI 445 Query: 203 HKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWL 262 + V V+F P G F++T D + LK + + V G +S Sbjct: 446 PAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMG--LDISS- 502 Query: 263 DSQKFATVGADATIRVW 279 D Q AT D T ++W Sbjct: 503 DGQLIATCSYDRTFKLW 519 Score = 86.5 bits (212), Expect = 3e-17, Method: Composition-based stats. Identities = 52/329 (15%), Positives = 110/329 (33%), Gaps = 68/329 (20%) Query: 304 VVATGNGR-IISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP------------L 350 + N + + + G + + +L T+ GHN + A+ +P L Sbjct: 237 CHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNL 296 Query: 351 ISGSYDGRIMEWSSSSMHQ-----DHSNLIVSLD-NSKAQEYSSISWDDTLKVNGITKHE 404 S + DG + WS S H+ + + + + + +D + ++ + E Sbjct: 297 ASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQE 356 Query: 405 --FGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVG 462 + + F G + + L++ G L + Sbjct: 357 EILHQEGHSMGVYDIAF--------------HQDGSLAGTGGLDAFGRVWDLRTGRCIMF 402 Query: 463 LEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREV 522 L EG+ +++ I+ SP+ +IA G ++DL+ R Sbjct: 403 L-EGHLKEIY--------------------GINFSPNGYHIATGSGDNTCKVWDLRQRRC 441 Query: 523 KTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNA 582 H + + + ++P I + + TG+ D I++ + K L Sbjct: 442 -VYTIPAHQNLVTGVKFEP---------IHGNFLLTGAYDNTAKIWTHPGWSPL-KTLAG 490 Query: 583 HKDGVNNLLWETPSTLVSSGA-DACIKRW 610 H+ V L + L+++ + D K W Sbjct: 491 HEGKVMGLDISSDGQLIATCSYDRTFKLW 519 Score = 49.5 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 20/123 (16%), Positives = 49/123 (39%), Gaps = 5/123 (4%) Query: 491 PSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEE 550 SY SP+ +A G L+ + + H + + AI + P K + Sbjct: 234 ISYCHFSPNSKMLATACWSGLCKLWSVPDCNL-LHTLRGHNTNVGAIVFHP--KSTVSLD 290 Query: 551 IEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLV-SSGADACIKR 609 ++ +A+ + D ++ ++S+ + + H V ++W + ++ D + Sbjct: 291 PKDVNLASCAADGSVKLWSLDSDEPVA-DIEGHTVRVARVMWHPSGRFLGTTCYDRSWRL 349 Query: 610 WNV 612 W++ Sbjct: 350 WDL 352 >5MZH-A nrPDB Length = 452 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 53/358 (14%), Positives = 122/358 (34%), Gaps = 26/358 (7%) Query: 100 ESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGH 159 E + + P+++ +++ G R R V+ ++ +G + + GH Sbjct: 78 EQQHHSFTLFKVLRAHILPLTNCAFNKSGDRFITGSYDR-TCKVWNTF-TGEEVFTLEGH 135 Query: 160 SQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSG 219 + A + +T D + + + T + + + F+P S Sbjct: 136 KNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLY---YTLKGHQTEIVCLSFNPQST 192 Query: 220 EFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVW 279 + T D +D ++G+ + + + F T D R+W Sbjct: 193 -IIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTG---GDLIVTGSFDHDSRLW 248 Query: 280 DVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHN 339 DV T +CV + + ++ + Q T ++S S+D T +++ L GH Sbjct: 249 DVRTGQCVHVLSGHRGEVSSTQFNYAGTL---VVSGSIDCTSRLWDVRSGRCLSVKQGHT 305 Query: 340 KGITALTVNP----LISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTL 395 + + + ++S S DG + + + H+ + E S ++++ Sbjct: 306 DEVLDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLV------GHEGEISKVAFNP-- 357 Query: 396 KVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSF--TGDIIKSVRLNSPGSA 451 + + ++ + VL D + +F GD I + ++ Sbjct: 358 QGTRLITASSDKTCRLWDCDTGECLQVLEGHTDEIFSCAFNYEGDFIITGSKDNTCRI 415 Score = 167 bits (421), Expect = 2e-41, Method: Composition-based stats. Identities = 52/316 (16%), Positives = 101/316 (31%), Gaps = 27/316 (8%) Query: 56 VVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVL 115 V GH + V +P + +G +W + + Sbjct: 129 VFTLEGHKNVVYAIAFNNPYGDK--IVTGSFDKTCKLWDAY--------TGQLYYTLKGH 178 Query: 116 AGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMR 175 I +S++ + + DN ++G ++GH I + Sbjct: 179 QTEIVCLSFNPQST--IIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGD-L 235 Query: 176 SMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFD 235 +T D + + H + V +F+ +G V++ D +D Sbjct: 236 IVTGSFDHDSRLWDVRTGQCVHVLSGHRGE---VSSTQFN-YAGTLVVSGSIDCTSRLWD 291 Query: 236 GKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQ 295 +SG L + + V F + K + AD + R++ T C + Sbjct: 292 VRSGRCLSVKQGHTDEVLDVAFDAA---GTKMVSASADGSARLYHTLTGVCQHTLVGHEG 348 Query: 296 QLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LI 351 ++ T R+I+ S D T ++ E L+ + GH I + N +I Sbjct: 349 EISKVAFNPQGT---RLITASSDKTCRLWDCDTGECLQVLEGHTDEIFSCAFNYEGDFII 405 Query: 352 SGSYDGRIMEWSSSSM 367 +GS D W + + Sbjct: 406 TGSKDNTCRIWKALTA 421 Score = 165 bits (418), Expect = 4e-41, Method: Composition-based stats. Identities = 56/368 (15%), Positives = 118/368 (32%), Gaps = 45/368 (12%) Query: 154 GEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVE 213 + H + C +S R +T D + + + T + V + Sbjct: 88 KVLRAHILPLTNCAFNKSGD-RFITGSYDRTCKVWNTFTGE---EVFTLEGHKNVVYAIA 143 Query: 214 FSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGAD 273 F+ G+ ++T D+ +D +G+ ++ Q + F S AT D Sbjct: 144 FNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFN---PQSTIIATGSMD 200 Query: 274 ATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLK 333 T ++WDV T + ++ TL + +G TG I++ S D +++ + + Sbjct: 201 NTAKLWDVETGQ--ERATLAGHRAEIVSLGF-NTGGDLIVTGSFDHDSRLWDVRTGQCVH 257 Query: 334 TISGHNKGITALTVN----PLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSI 389 +SGH +++ N ++SGS D W S +S+ E + Sbjct: 258 VLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGR------CLSVKQGHTDEVLDV 311 Query: 390 SWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSF--TGDIIKSVRLNS 447 ++D + ++ L + + +F G + + + Sbjct: 312 AFDAA--GTKMVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTRLITASSDK 369 Query: 448 PGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGD 507 L EG+T ++F + + +I G Sbjct: 370 TCRLWDCDTGECLQVL-EGHTDEIF--------------------SCAFNYEGDFIITGS 408 Query: 508 VMGKILLY 515 ++ Sbjct: 409 KDNTCRIW 416 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 59/343 (17%), Positives = 118/343 (34%), Gaps = 36/343 (10%) Query: 67 VTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDF 126 +T F+ K +G VW +E ++E + + + + Sbjct: 97 LTNCAFN--KSGDRFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFN-------NP 147 Query: 127 EGRRLCVVGEGRDNFGVFISWD--SGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGS 184 G ++ + WD +G + GH I + T D + Sbjct: 148 YGDKIVTGSFDK----TCKLWDAYTGQLYYTLKGHQTEIVCLSFNP-QSTIIATGSMDNT 202 Query: 185 VVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKY 244 + + A+ H + + + F+ G+ ++T D +D ++G+ + Sbjct: 203 AKLWDVETGQERATLAGHRAE---IVSLGFNT-GGDLIVTGSFDHDSRLWDVRTGQCVHV 258 Query: 245 IEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGV 304 + + V F + + D T R+WDV + +C+ V Sbjct: 259 LSGHRGEVSSTQFNYA---GTLVVSGSIDCTSRLWDVRSGRCLS--VKQGHTDEVLDVAF 313 Query: 305 VATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIM 360 A G +++S S DG+ Y T+ GH I+ + NP LI+ S D Sbjct: 314 DAAG-TKMVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTRLITASSDKTCR 372 Query: 361 EWSSSSMH-----QDHSNLIVSLDNSKAQEY-SSISWDDTLKV 397 W + + H++ I S + ++ + S D+T ++ Sbjct: 373 LWDCDTGECLQVLEGHTDEIFSCAFNYEGDFIITGSKDNTCRI 415 Score = 140 bits (353), Expect = 1e-33, Method: Composition-based stats. Identities = 60/386 (15%), Positives = 124/386 (32%), Gaps = 63/386 (16%) Query: 240 EFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGN 299 K + P+ F S +F T D T +VW+ T + V +TL+ + Sbjct: 85 TLFKVLRAHILPLTNCAFNKS---GDRFITGSYDRTCKVWNTFTGEEV--FTLEGHKNVV 139 Query: 300 QQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSY 355 + +I++ S D T ++ ++ T+ GH I L+ NP + +GS Sbjct: 140 YAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQSTIIATGSM 199 Query: 356 DGRIMEWSSSSMHQ-----DHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPK 410 D W + + H IVSL + + I F + Sbjct: 200 DNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGDL-------------IVTGSFDHDSR 246 Query: 411 VASANNDGFTAVLTNDDDLLILQSFT--GDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNT 468 + VL+ + F G ++ S ++ + + G+T Sbjct: 247 LWDVRTGQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQ-GHT 305 Query: 469 IQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWA 528 +V ++ + T + + G LY + + Sbjct: 306 DEVLD--------------------VAFDAAGTKMVSASADGSARLYHTLTGVCQ-HTLV 344 Query: 529 FHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVN 588 H +I+ +++ P + + T S D ++ + ++ L H D + Sbjct: 345 GHEGEISKVAFNP----------QGTRLITASSDKTCRLWDCD-TGECLQVLEGHTDEIF 393 Query: 589 NLLWETPSTLVSSGA-DACIKRWNVV 613 + + + +G+ D + W + Sbjct: 394 SCAFNYEGDFIITGSKDNTCRIWKAL 419 Score = 111 bits (277), Expect = 9e-25, Method: Composition-based stats. Identities = 41/230 (17%), Positives = 71/230 (30%), Gaps = 25/230 (10%) Query: 59 FTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGP 118 GH + +V+ G + +G +W G Sbjct: 217 LAGHRAEIVS---LGFNTGGDLIVTGSFDHDSRLWDVR--------TGQCVHVLSGHRGE 265 Query: 119 ISDISWDFEGRRLCVVGEGRDNFGVFISWD--SGNSLGEVSGHSQRINACHLKQSRPMRS 176 +S +++ G + WD SG L GH+ + + + Sbjct: 266 VSSTQFNYAGTLVVSGSID----CTSRLWDVRSGRCLSVKQGHTDEVLDVAFDAAG-TKM 320 Query: 177 MTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDG 236 ++ DGS Y T + V F+P G +IT SD+ +D Sbjct: 321 VSASADGSARLY---HTLTGVCQHTLVGHEGEISKVAFNP-QGTRLITASSDKTCRLWDC 376 Query: 237 KSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKC 286 +GE L+ +E + + F + T D T R+W T+ Sbjct: 377 DTGECLQVLEGHTDEIFSCAFN---YEGDFIITGSKDNTCRIWKALTASS 423 >4V8M-A7 nrPDB Length = 318 Score = 174 bits (441), Expect = 8e-44, Method: Composition-based stats. Identities = 49/311 (15%), Positives = 117/311 (37%), Gaps = 30/311 (9%) Query: 154 GEVSGHSQRINA--CHLKQSRPMRSMTVGDDGSVVFYQGPPFK------FSASDRTHHKQ 205 G+++GH + + C + ++ D +++ + P + + DR Sbjct: 7 GQLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGH 66 Query: 206 GSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQ 265 +FV DV S ++G F ++ D + ++ ++G+ + V F+ D++ Sbjct: 67 SAFVSDVALS-NNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFS---PDNR 122 Query: 266 KFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGN-GRIISLSLDGTLNFY 324 + + G D +RVW+V +C+ + V + + I+S D + + Sbjct: 123 QIVSGGRDNALRVWNVK-GECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVW 181 Query: 325 ELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQDHS----NLIV 376 +L ++ + GH +T++TV+P S DG W + I Sbjct: 182 DLATGRLVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPIN 241 Query: 377 SLDNSKAQEYSSISWDDTLKV------NGITKHEFGSQPKVASANNDGFTAVLTNDDDLL 430 + S + + + + +++ + I + Q ++ + D Sbjct: 242 QICFSPNRYWMCAATEKGIRIFDLENKDIIVELAPEHQGSKKIVPE--CVSIAWSADGST 299 Query: 431 ILQSFTGDIIK 441 + +T ++I+ Sbjct: 300 LYSGYTDNVIR 310 Score = 127 bits (319), Expect = 1e-29, Method: Composition-based stats. Identities = 47/323 (14%), Positives = 109/323 (33%), Gaps = 26/323 (8%) Query: 58 QFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNV-KSEFQVLA 116 Q TGH V + + + + S ++ WG D+ S+ + + + Sbjct: 8 QLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHS 67 Query: 117 GPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRS 176 +SD++ G + +G + GH++ + + + Sbjct: 68 AFVSDVALSNNGNFAVSASWDHSLR--LWNLQNGQCQYKFLGHTKDVLSVAFSP-DNRQI 124 Query: 177 MTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPD-SGEFVITVGSDRKISCFD 235 ++ G D ++ + + + +V V FSP +++ G D + +D Sbjct: 125 VSGGRDNALRVWNV-KGECMHTLSR-GAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWD 182 Query: 236 GKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQ 295 +G + ++ V + D A+ D R+WD+T + + + Sbjct: 183 LATGRLVTDLKGHTNYVTSVTVS---PDGSLCASSDKDGVARLWDLTKGEALSEMAA--- 236 Query: 296 QLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTI----SGHNKGI-------TA 344 G + + N + + + + ++L + +++ + G K + + Sbjct: 237 --GAPINQICFSPNRYWMCAATEKGIRIFDLENKDIIVELAPEHQGSKKIVPECVSIAWS 294 Query: 345 LTVNPLISGSYDGRIMEWSSSSM 367 + L SG D I W S Sbjct: 295 ADGSTLYSGYTDNVIRVWGVSEN 317 Score = 68.0 bits (164), Expect = 1e-11, Method: Composition-based stats. Identities = 55/350 (15%), Positives = 118/350 (33%), Gaps = 71/350 (20%) Query: 291 TLDKQQLGNQQVGVVATGNG--RIISLSLDGTLNFY----ELGHDEVLK-----TISGHN 339 L + + T +++S S D TL + + E + GH+ Sbjct: 8 QLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHS 67 Query: 340 KGITALTVNP----LISGSYDGRIMEWSSSSM-----HQDHSNLIVSLDNSK-AQEYSSI 389 ++ + ++ +S S+D + W+ + H+ ++S+ S ++ S Sbjct: 68 AFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQIVSG 127 Query: 390 SWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPG 449 D+ L+V + + + A + + D +I+ +++K L + Sbjct: 128 GRDNALRVWNVKGECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGR 187 Query: 450 SAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVM 509 L +G+T V + +++SP + A+ D Sbjct: 188 LVTDL----------KGHTNYV--------------------TSVTVSPDGSLCASSDKD 217 Query: 510 GKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYS 569 G L+DL E + A + IN I + P + + I I+ Sbjct: 218 GVARLWDLTKGEALSEMAAG--APINQICFSP-----------NRYWMCAATEKGIRIFD 264 Query: 570 VKRPMKIIKALNAHKD------GVNNLLWETPSTLVSSG-ADACIKRWNV 612 ++ I++ H+ ++ W + + SG D I+ W V Sbjct: 265 LENKDIIVELAPEHQGSKKIVPECVSIAWSADGSTLYSGYTDNVIRVWGV 314 >6ELZ-p nrPDB Length = 460 Score = 174 bits (440), Expect = 1e-43, Method: Composition-based stats. Identities = 70/326 (21%), Positives = 127/326 (38%), Gaps = 62/326 (19%) Query: 77 GSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGE 136 GS+++ SG G V W + NV+ ++ +GPI + + RL G Sbjct: 114 GSKHIISGSYDGIVRTW---------DLSGNVQKQYSGHSGPIRAVKY-ISNTRLVSAGN 163 Query: 137 GR---------DNFGV------------FISWDSGNSLGEVSGHSQRINACHLKQSRPMR 175 R D+ + ++ + G +L + GH + + S R Sbjct: 164 DRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPV--VSIDVSDNSR 221 Query: 176 SMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDR-KISCF 234 ++ D S+ F+ T +K+ + V +E + + T R K++ Sbjct: 222 ILSASYDNSIGFWS-----------TIYKEMTVVDPLEDINNPNNKISTAARKRRKLTMK 270 Query: 235 DG--KSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTL 292 DG + L +E PV+ IF + D+ +V D TI+ WD+ T++C+ T Sbjct: 271 DGTIRRRAPLSLLESHTAPVEQVIFDST--DNTVGYSVSQDHTIKTWDLVTARCIDTRTT 328 Query: 293 DKQQLGNQQ---VGVVATG-NGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVN 348 L Q + ++A G + R I+L ++ +++ GH +++L Sbjct: 329 SYSLLSIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQLI----GHKNFVSSLDTC 384 Query: 349 P-----LISGSYDGRIMEWSSSSMHQ 369 P L SGS+DG + W S Sbjct: 385 PENEYILCSGSHDGTVKVWDVRSTSP 410 Score = 76.1 bits (185), Expect = 4e-14, Method: Composition-based stats. Identities = 56/393 (14%), Positives = 128/393 (32%), Gaps = 82/393 (20%) Query: 253 QGGIFALSWLDSQK-FATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGR 311 + + +L D K + D +R WD+ + ++++ + + N R Sbjct: 103 EDWVSSLDVGDGSKHIISGSYDGIVRTWDL-SGNVQKQYSGHSGPIRAVK----YISNTR 157 Query: 312 IISLSLDGTLNFY-----------------------ELGHDEVLKTISGHNKGITALTVN 348 ++S D TL + + + L + GH + ++ V+ Sbjct: 158 LVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDVS 217 Query: 349 ---PLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEF 405 ++S SYD I WS+ + + ++N + ++ L + T Sbjct: 218 DNSRILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLTMKDGTIRRR 277 Query: 406 GSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEE 465 + S + + D+ + IK+ L + + + +Y + + + Sbjct: 278 APLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDTRTTSYSLLSIAQ 337 Query: 466 GNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDL---QSREV 522 +T+ + +A G I L+D S +V Sbjct: 338 LSTLNL-------------------------------LACGSSARHITLHDPRVGASSKV 366 Query: 523 KTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNA 582 + H + ++++ P E ++ +GS D + ++ V+ + Sbjct: 367 TQQQLIGHKNFVSSLDTCPE---------NEYILCSGSHDGTVKVWDVRSTSPMYTITRE 417 Query: 583 HK-------DGVNNLLWETPSTLVSSGADACIK 608 K D V + W ++S+G D I+ Sbjct: 418 DKSVQKGVNDKVFAVKWAEKVGIISAGQDKKIQ 450 Score = 71.9 bits (174), Expect = 7e-13, Method: Composition-based stats. Identities = 58/368 (15%), Positives = 117/368 (31%), Gaps = 89/368 (24%) Query: 217 DSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATI 276 D + +I+ D + +D ++ G I A+ ++ + + + G D T+ Sbjct: 113 DGSKHIISGSYDGIVRTWDLSGN-----VQKQYSGHSGPIRAVKYISNTRLVSAGNDRTL 167 Query: 277 RVW-----------------------DVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRII 313 R+W ++ K + K + V + + N RI+ Sbjct: 168 RLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPV----VSIDVSDNSRIL 223 Query: 314 SLSLDGTLNFYELGHDEV-----LKTISGHNKGITALTVNPLISGSYDGRIMEWSSSSMH 368 S S D ++ F+ + E+ L+ I+ N I+ DG I + S+ Sbjct: 224 SASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLTMKDGTIRRRAPLSLL 283 Query: 369 QDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAV-LTNDD 427 + H+ + + S D+T+ + K T+ Sbjct: 284 ESHTAPVEQVIFD--------STDNTVGYS----VSQDHTIKTWDLVTARCIDTRTTSYS 331 Query: 428 DLLILQSFTGDIIKSVR-------LNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVS 480 L I Q T +++ + A S +G + +S L+ Sbjct: 332 LLSIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQLIGHKN-------FVSSLDTC 384 Query: 481 FDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQS--------REVKTSRWAFHTS 532 + +E + +G G + ++D++S RE K S Sbjct: 385 PE----------------NEYILCSGSHDGTVKVWDVRSTSPMYTITREDK-SVQKGVND 427 Query: 533 KINAISWK 540 K+ A+ W Sbjct: 428 KVFAVKWA 435 Score = 68.8 bits (166), Expect = 6e-12, Method: Composition-based stats. Identities = 33/269 (12%), Positives = 78/269 (28%), Gaps = 64/269 (23%) Query: 56 VVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVL 115 + GH + VV+ + + + S + W + E+ V + + Sbjct: 201 LAILEGHKAPVVSI----DVSDNSRILSASYDNSIGFWSTIYK------EMTVVDPLEDI 250 Query: 116 AGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMR 175 P + IS RR + +G + L + H+ + + Sbjct: 251 NNPNNKISTAARKRRKLTMKDG--------TIRRRAPLSLLESHTAPVEQVIFDSTDNTV 302 Query: 176 SMTVGDDGSVVFYQGPPFKF---------------------------------------- 195 +V D ++ + + Sbjct: 303 GYSVSQDHTIKTWDLVTARCIDTRTTSYSLLSIAQLSTLNLLACGSSARHITLHDPRVGA 362 Query: 196 --SASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYI----EDDQ 249 + + +FV ++ P++ + + D + +D +S + I + Q Sbjct: 363 SSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITREDKSVQ 422 Query: 250 EPVQGGIFALSWLDSQKFATVGADATIRV 278 + V +FA+ W + + G D I++ Sbjct: 423 KGVNDKVFAVKWAEKVGIISAGQDKKIQI 451 Score = 41.8 bits (96), Expect = 9e-04, Method: Composition-based stats. Identities = 25/106 (23%), Positives = 39/106 (36%), Gaps = 8/106 (7%) Query: 37 CGKSAFVRCLDD---GDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYL-CSGDESGKVIV 92 CG SA L D G S Q GH + V + ++Y+ CSG G V V Sbjct: 346 CGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSS---LDTCPENEYILCSGSHDGTVKV 402 Query: 93 WGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGR 138 W ++ KS + + + + W E + G+ + Sbjct: 403 WDVRSTSPMYTITREDKSVQKGVNDKVFAVKW-AEKVGIISAGQDK 447 Score = 39.1 bits (89), Expect = 0.006, Method: Composition-based stats. Identities = 23/145 (15%), Positives = 48/145 (33%), Gaps = 35/145 (24%) Query: 491 PSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEE 550 S + + +I +G G + +DL K +++ H+ I A+ + Sbjct: 106 VSSLDVGDGSKHIISGSYDGIVRTWDLSGNVQK--QYSGHSGPIRAVKY----------- 152 Query: 551 IEEDLVATGSLDTNIFIYSVK----------------------RPMKIIKALNAHKDGVN 588 I + + D + ++ K K + L HK V Sbjct: 153 ISNTRLVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVV 212 Query: 589 NLLWETPSTLVSSGADACIKRWNVV 613 ++ S ++S+ D I W+ + Sbjct: 213 SIDVSDNSRILSASYDNSIGFWSTI 237 >5NNZ-B nrPDB Length = 415 Score = 172 bits (434), Expect = 5e-43, Method: Composition-based stats. Identities = 59/361 (16%), Positives = 127/361 (35%), Gaps = 30/361 (8%) Query: 99 KESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWD--SGNSLGEV 156 ++++ + + P+++++ + G R WD SG L + Sbjct: 75 GQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDR----TCKLWDTASGEELNTL 130 Query: 157 SGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSP 216 GH + A + T D + + K + R H + + + F+P Sbjct: 131 EGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAE---IVCLSFNP 187 Query: 217 DSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATI 276 S V T D +D ++GE + + + F S + T D T+ Sbjct: 188 QST-LVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTS---GDRIITGSFDHTV 243 Query: 277 RVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTIS 336 VWD T + V ++ + + I++ S+D T ++ + + + T++ Sbjct: 244 VVWDADTGRKVNILIGHCAEISSASFNWDCSL---ILTGSMDKTCKLWDATNGKCVATLT 300 Query: 337 GHNKGI--TALTVN--PLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWD 392 GH+ I + + + S DG +S+++ ++ E S IS++ Sbjct: 301 GHDDEILDSCFDYTGKLIATASADGTARIFSAATRK------CIAKLEGHEGEISKISFN 354 Query: 393 DTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSF--TGDIIKSVRLNSPGS 450 + N + ++ A VL D + +F G+I+ + ++ Sbjct: 355 P--QGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCR 412 Query: 451 A 451 Sbjct: 413 I 413 Score = 168 bits (426), Expect = 4e-42, Method: Composition-based stats. Identities = 73/417 (17%), Positives = 134/417 (32%), Gaps = 90/417 (21%) Query: 204 KQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQ----EPVQGGIFAL 259 + V + E ++T ++ + E L + + ++ I L Sbjct: 36 GPSTDVSALVEEIQKAEPLLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPL 95 Query: 260 SWLDSQK----FATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISL 315 + + K F T D T ++WD + + + TL+ + + +I + Sbjct: 96 TNVALNKSGSCFITGSYDRTCKLWDTASGEELN--TLEGHRNVVYAIAFNNPYGDKIATG 153 Query: 316 SLDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQ-- 369 S D T + + + T GH I L+ NP + +GS D W + + Sbjct: 154 SFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVY 213 Query: 370 ---DHSNLIVSLDN---------------------------------SKAQEYSSISWDD 393 HS I+SL +S +WD Sbjct: 214 TLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDC 273 Query: 394 TLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSF--TGDIIKSVRLNSPGSA 451 +L + G K+ A N A LT DD ++ F TG +I + + Sbjct: 274 SLILTG----SMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARI 329 Query: 452 VSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGK 511 S + L EG+ ++ K IS +P ++ G Sbjct: 330 FSAATRKCIAKL-EGHEGEISK--------------------ISFNPQGNHLLTGSSDKT 368 Query: 512 ILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIY 568 ++D Q+ + HT +I + ++ + ++V TGS D I+ Sbjct: 369 ARIWDAQTGQC-LQVLEGHTDEIFSCAFN----------YKGNIVITGSKDNTCRIW 414 Score = 159 bits (401), Expect = 3e-39, Method: Composition-based stats. Identities = 57/368 (15%), Positives = 117/368 (31%), Gaps = 45/368 (12%) Query: 154 GEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVE 213 + H + L +S +T D + + + T + V + Sbjct: 86 KVLKAHILPLTNVALNKSG-SCFITGSYDRTCKLWDTASGE---ELNTLEGHRNVVYAIA 141 Query: 214 FSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGAD 273 F+ G+ + T D+ + ++G+ + F S AT D Sbjct: 142 FNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFN---PQSTLVATGSMD 198 Query: 274 ATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLK 333 T ++WD+ + V +TL + +G+ RII+ S D T+ ++ + Sbjct: 199 TTAKLWDIQNGEEV--YTLRGHSAEIISLSFNTSGD-RIITGSFDHTVVVWDADTGRKVN 255 Query: 334 TISGHNKGITALTVN----PLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSI 389 + GH I++ + N +++GS D W ++ + V+ E Sbjct: 256 ILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDAT------NGKCVATLTGHDDEILDS 309 Query: 390 SWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSF--TGDIIKSVRLNS 447 +D T K+ I ++ SA A L + + SF G+ + + + Sbjct: 310 CFDYTGKL--IATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDK 367 Query: 448 PGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGD 507 L EG+T ++F + + + G Sbjct: 368 TARIWDAQTGQCLQVL-EGHTDEIF--------------------SCAFNYKGNIVITGS 406 Query: 508 VMGKILLY 515 ++ Sbjct: 407 KDNTCRIW 414 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 58/369 (15%), Positives = 117/369 (31%), Gaps = 34/369 (9%) Query: 49 GDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNV 108 G + F + ++ + K +G +W +E N++E + Sbjct: 75 GQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHR 134 Query: 109 KSEFQV-LAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACH 167 + + P D + D S ++G GH+ I Sbjct: 135 NVVYAIAFNNPYGD----------KIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLS 184 Query: 168 LKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGS 227 + T D + + + T + + + F+ SG+ +IT Sbjct: 185 FNP-QSTLVATGSMDTTAKLWDIQNGE---EVYTLRGHSAEIISLSFNT-SGDRIITGSF 239 Query: 228 DRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCV 287 D + +D +G + + + F D T D T ++WD T KCV Sbjct: 240 DHTVVVWDADTGRKVNILIGHCAEISSASFN---WDCSLILTGSMDKTCKLWDATNGKCV 296 Query: 288 QKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTV 347 T ++ + I + S DGT + + + + GH I+ ++ Sbjct: 297 ATLTGHDDEILD---SCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISF 353 Query: 348 NP----LISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKH 403 NP L++GS D W + + + + E S +++ K N + Sbjct: 354 NPQGNHLLTGSSDKTARIWDAQTGQ------CLQVLEGHTDEIFSCAFNY--KGNIVITG 405 Query: 404 EFGSQPKVA 412 + ++ Sbjct: 406 SKDNTCRIW 414 Score = 66.9 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 39/275 (14%), Positives = 97/275 (35%), Gaps = 44/275 (16%) Query: 346 TVNPLISGSYDGRI-----MEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGI 400 PL++ S ++ + +H+ + + + ++++ + + + Sbjct: 50 KAEPLLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKS--GSCF 107 Query: 401 TKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFT---GDIIKSVRLNSPGSAVSLSQN 457 + K+ + L +++ +F GD I + + S+ Sbjct: 108 ITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETG 167 Query: 458 YVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDL 517 G+T ++ LS +P T +A G + L+D+ Sbjct: 168 KCYHTFR-GHTAEIVCLS--------------------FNPQSTLVATGSMDTTAKLWDI 206 Query: 518 QSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKII 577 Q+ E + H+++I ++S+ + D + TGS D + ++ K+ Sbjct: 207 QNGE-EVYTLRGHSAEIISLSFNTS----------GDRIITGSFDHTVVVWDADTGRKVN 255 Query: 578 KALNAHKDGVNNLLWETPSTLVSSGA-DACIKRWN 611 L H +++ + +L+ +G+ D K W+ Sbjct: 256 I-LIGHCAEISSASFNWDCSLILTGSMDKTCKLWD 289 >5UZ7-B nrPDB Length = 351 Score = 168 bits (426), Expect = 5e-42, Method: Composition-based stats. Identities = 51/314 (16%), Positives = 113/314 (35%), Gaps = 33/314 (10%) Query: 59 FTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGP 118 GH + + S+ L S + GK+I+W + +++ + P Sbjct: 62 LRGHLAKIY---AMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP 118 Query: 119 ISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSL----GEVSGHSQRINACHLKQSRPM 174 + V G DN + + E++GH+ ++ C Sbjct: 119 SGN----------YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDN-- 166 Query: 175 RSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCF 234 + +T D + + + + + H V + +PD+ ++ D + Sbjct: 167 QIVTSSGDTTCALWDIETGQQTTTFTGHTGD---VMSLSLAPDT-RLFVSGACDASAKLW 222 Query: 235 DGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDK 294 D + G + + + F + + FAT DAT R++D+ + + ++ D Sbjct: 223 DVREGMCRQTFTGHESDINAICF---FPNGNAFATGSDDATCRLFDLRADQELMTYSHDN 279 Query: 295 QQLGNQQVGVVATGNGRIISLSLDGT-LNFYELGHDEVLKTISGHNKGITALTVNP---- 349 G V + +GR++ D N ++ + ++GH+ ++ L V Sbjct: 280 IICGITSVSF--SKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMA 337 Query: 350 LISGSYDGRIMEWS 363 + +GS+D + W+ Sbjct: 338 VATGSWDSFLKIWN 351 Score = 88.8 bits (218), Expect = 6e-18, Method: Composition-based stats. Identities = 38/250 (15%), Positives = 81/250 (32%), Gaps = 32/250 (12%) Query: 198 SDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIF 257 + RT + + + + D +++ D K+ +D + + I V + Sbjct: 58 TRRTLRGHLAKIYAMHWGTD-SRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY 116 Query: 258 ALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSL 317 A S A G D ++++ T + + + + + +I++ S Sbjct: 117 APS---GNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG 173 Query: 318 DGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSM-----H 368 D T +++ + T +GH + +L++ P +SG+ D W Sbjct: 174 DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTF 233 Query: 369 QDHSNLIVSLDNSKAQEYSSISWDDTL-------------------KVNGITKHEFGSQP 409 H + I ++ + DD + GIT F Sbjct: 234 TGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSG 293 Query: 410 KVASANNDGF 419 ++ A D F Sbjct: 294 RLLLAGYDDF 303 Score = 58.4 bits (139), Expect = 8e-09, Method: Composition-based stats. Identities = 43/341 (12%), Positives = 93/341 (27%), Gaps = 89/341 (26%) Query: 280 DVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYEL------------- 326 D ++ + L T + ++S S DG L ++ Sbjct: 49 DPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRS 108 Query: 327 ---------------------------------GHDEVLKTISGHNKGITALTV---NPL 350 G+ V + ++GH ++ N + Sbjct: 109 SWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQI 168 Query: 351 ISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPK 410 ++ S D W + ++ S++ D L V+G + K Sbjct: 169 VTSSGDTTCALWDI----ETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGAC----DASAK 220 Query: 411 VASANNDGFTAVLTNDDDLLILQSF--TGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNT 468 + T + + F G+ + ++ L + + N Sbjct: 221 LWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNI 280 Query: 469 IQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWA 528 I + +S S S + AG ++D + + A Sbjct: 281 I-------------------CGITSVSFSKSGRLLLAGYDDFNCNVWDALKAD-RAGVLA 320 Query: 529 FHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYS 569 H ++++ + + VATGS D+ + I++ Sbjct: 321 GHDNRVSCLG----------VTDDGMAVATGSWDSFLKIWN 351 Score = 36.4 bits (82), Expect = 0.041, Method: Composition-based stats. Identities = 15/82 (18%), Positives = 26/82 (31%), Gaps = 11/82 (13%) Query: 526 RWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKD 585 H +KI A+ W + L+ + S D + I+ K+ A+ Sbjct: 61 TLRGHLAKIYAMHWGTDSR----------LLVSASQDGKLIIWDSYTTNKV-HAIPLRSS 109 Query: 586 GVNNLLWETPSTLVSSGADACI 607 V + V+ G I Sbjct: 110 WVMTCAYAPSGNYVACGGLDNI 131 >6EMK-B nrPDB Length = 303 Score = 166 bits (420), Expect = 3e-41, Method: Composition-based stats. Identities = 62/309 (20%), Positives = 111/309 (35%), Gaps = 61/309 (19%) Query: 43 VRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESN 102 VR D + PV F GH +V T+V F + ++++ + E G + VW D S Sbjct: 55 VRLYDIRTTNPNPVASFEGHRGNV-TSVSFQ--QDNRWMVTSSEDGTIKVW----DVRSP 107 Query: 103 SVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWD-SGNSLGEVSGHSQ 161 S+ N K P++++ N G IS D GN G +Q Sbjct: 108 SIPRNYKHN-----APVNEVV-------------IHPNQGELISCDRDGNIRIWDLGENQ 149 Query: 162 RINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEF 221 + + ++S+++ DGS++ + +H S ++ V + Sbjct: 150 CTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTY 209 Query: 222 VITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDV 281 + L D + AT AD T RVW + Sbjct: 210 I---------------------------------TRILLSSDVKHLATCSADHTARVWSI 236 Query: 282 TTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKG 341 ++ TLD Q A + +++ S D + ++L E+++ GH+KG Sbjct: 237 DDDFKLET-TLDGHQRWVWDCAFSA-DSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKG 294 Query: 342 ITALTVNPL 350 + +N + Sbjct: 295 AVCVALNDV 303 Score = 95.4 bits (235), Expect = 7e-20, Method: Composition-based stats. Identities = 57/324 (17%), Positives = 119/324 (36%), Gaps = 36/324 (11%) Query: 222 VITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDV 281 +++ G D I ++ +G + I+ V D + AT G +R++D+ Sbjct: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITN---DKKLLATAGHQN-VRLYDI 60 Query: 282 TTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKG 341 T+ + + + V N +++ S DGT+ +++ + + HN Sbjct: 61 RTTNPNPVASFEGHRGNVTSVSFQ-QDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAP 118 Query: 342 ITALTVNP----LISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKV 397 + + ++P LIS DG I W H + D++ Q S++ D ++ Sbjct: 119 VNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQ--LTPEDDTSLQS-LSMASDGSMLA 175 Query: 398 NGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQN 457 TK V N + L ++ I+ +S Sbjct: 176 AANTKG----NCYVWEMPNHTDASHLKPVTKFRAHSTYITRIL-----------LSSDVK 220 Query: 458 YVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYI---SISPSETYIAAGDVMGKILL 514 ++A + +T +V+ + D F L+T L ++ + S Y+ + L Sbjct: 221 HLATCSAD-HTARVWSIDDD---FKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRL 276 Query: 515 YDLQSREVKTSRWAFHTSKINAIS 538 +DL +RE+ ++ H ++ Sbjct: 277 WDLSTREI-VRQYGGHHKGAVCVA 299 Score = 86.5 bits (212), Expect = 3e-17, Method: Composition-based stats. Identities = 52/304 (17%), Positives = 112/304 (36%), Gaps = 40/304 (13%) Query: 176 SMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFD 235 ++ G D ++ F++ RT S V +E + D ++ + + +D Sbjct: 5 LVSAGYDHTIRFWEALT---GVCSRTIQHSDSQVNRLEITNDK--KLLATAGHQNVRLYD 59 Query: 236 GKSG--EFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLD 293 ++ + E + V F D++ T D TI+VWDV + + + Sbjct: 60 IRTTNPNPVASFEGHRGNVTSVSF---QQDNRWMVTSSEDGTIKVWDVRSPSIPRNY--- 113 Query: 294 KQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNK-GITALTV----N 348 K +V + G +IS DG + ++LG ++ ++ + + +L++ + Sbjct: 114 KHNAPVNEVVIHPN-QGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGS 172 Query: 349 PLISGSYDGRIMEWS-----------SSSMHQDHSNLIVS-LDNSKAQEYSSISWDDTLK 396 L + + G W + + HS I L +S + ++ S D T + Sbjct: 173 MLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTAR 232 Query: 397 VNGITKHEF------GSQPKVAS---ANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNS 447 V I G Q V + + + ++D + + T +I++ + Sbjct: 233 VWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHH 292 Query: 448 PGSA 451 G+ Sbjct: 293 KGAV 296 Score = 70.3 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 46/313 (14%), Positives = 117/313 (37%), Gaps = 50/313 (15%) Query: 312 IISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVN----PLISGSYDGRIMEWSSSSM 367 ++S D T+ F+E +TI + + L + L + + + + + Sbjct: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQN-VRLYDIRTT 63 Query: 368 HQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDD 427 + N + S + +S+S+ ++ + + D Sbjct: 64 NP---NPVASFE-GHRGNVTSVSFQQ----------------------DNRWMVTSSEDG 97 Query: 428 DLLILQSFTGDIIKSVRLNSPG--SAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKT 485 + + + I ++ + N+P + +Q + +GN I+++ L + + + L Sbjct: 98 TIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGN-IRIWDLGENQCTHQLTP 156 Query: 486 PLRAKPSYISISPSETYIAAGDVMGKILLYDL-----QSREVKTSRWAFHTSKINAISWK 540 +S++ + +AA + G ++++ S +++ H++ I I Sbjct: 157 EDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLS 216 Query: 541 PAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPST-LV 599 K +AT S D ++S+ K+ L+ H+ V + + S LV Sbjct: 217 SDVKH----------LATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLV 266 Query: 600 SSGADACIKRWNV 612 ++ +D ++ W++ Sbjct: 267 TASSDHYVRLWDL 279 >5OPT-p nrPDB Length = 318 Score = 166 bits (419), Expect = 3e-41, Method: Composition-based stats. Identities = 50/311 (16%), Positives = 114/311 (36%), Gaps = 30/311 (9%) Query: 154 GEVSGHSQRINACHLKQSRPMRS--MTVGDDGSVVFYQGPPFK------FSASDRTHHKQ 205 G++ GH + A Q ++ D +++ + + + +R Sbjct: 7 GQLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGH 66 Query: 206 GSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQ 265 +FV DV S ++G+F ++ D + ++ ++G + V F+ D++ Sbjct: 67 SAFVSDVALS-NNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFS---PDNR 122 Query: 266 KFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGN-GRIISLSLDGTLNFY 324 + + G D +RVW+V +C+ V + I+S D + + Sbjct: 123 QIVSGGRDNALRVWNVK-GECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVW 181 Query: 325 ELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQDHS----NLIV 376 ++ +L + GH IT++TV+P S DG W + I Sbjct: 182 DIASGRLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPIN 241 Query: 377 SLDNSKAQEYSSISWDDTLKV------NGITKHEFGSQPKVASANNDGFTAVLTNDDDLL 430 + S + + + + +++ + I + +Q K ++ + D Sbjct: 242 QICFSPNRYWMCAATEKGIRIFDLENKDVIVELAPEAQQKSKKTPE--CMSIAWSADGNT 299 Query: 431 ILQSFTGDIIK 441 + +T ++I+ Sbjct: 300 LYSGYTDNVIR 310 Score = 124 bits (311), Expect = 1e-28, Method: Composition-based stats. Identities = 50/321 (15%), Positives = 104/321 (32%), Gaps = 26/321 (8%) Query: 58 QFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNV-KSEFQVLA 116 Q GH V + S +I WG D+ S E + + + Sbjct: 8 QLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHS 67 Query: 117 GPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRS 176 +SD++ G + +G + GH++ + + + Sbjct: 68 AFVSDVALSNNGDFAVSASWDHSLR--LWNLQTGVCQHKFLGHTKDVLSVTFSP-DNRQI 124 Query: 177 MTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPD-SGEFVITVGSDRKISCFD 235 ++ G D ++ + + + +V V FSP +++ G D + +D Sbjct: 125 VSGGRDNALRVWNV-KGECLHTL-GRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWD 182 Query: 236 GKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQ 295 SG L ++ + + D A+ D R+WD+T + + + Sbjct: 183 IASGRLLTDLKGHTNYITSVTVS---PDGSLCASSDKDGVARLWDLTKGEALSEMAA--- 236 Query: 296 QLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHN-----------KGITA 344 G + + N + + + + ++L + +V+ ++ + Sbjct: 237 --GAPINQICFSPNRYWMCAATEKGIRIFDLENKDVIVELAPEAQQKSKKTPECMSIAWS 294 Query: 345 LTVNPLISGSYDGRIMEWSSS 365 N L SG D I WS S Sbjct: 295 ADGNTLYSGYTDNVIRVWSVS 315 Score = 63.8 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 51/344 (14%), Positives = 113/344 (32%), Gaps = 59/344 (17%) Query: 291 TLDKQQLGNQQVGVVATGNGRI--ISLSLDGTLNFY----ELGHDEVLK-----TISGHN 339 L + + I +S S D TL + + +E + GH+ Sbjct: 8 QLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHS 67 Query: 340 KGITALTVNP----LISGSYDGRIMEWSSSSM-----HQDHSNLIVSLDNSK-AQEYSSI 389 ++ + ++ +S S+D + W+ + H+ ++S+ S ++ S Sbjct: 68 AFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQIVSG 127 Query: 390 SWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPG 449 D+ L+V + + + A + + + LI+ +++K + S Sbjct: 128 GRDNALRVWNVKGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASGR 187 Query: 450 SAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVM 509 L +G+T + + +++SP + A+ D Sbjct: 188 LLTDL----------KGHTNYI--------------------TSVTVSPDGSLCASSDKD 217 Query: 510 GKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYS 569 G L+DL E + A + IN I + P + + + ++ + Sbjct: 218 GVARLWDLTKGEALSEMAAG--APINQICFSPNRYWMCAATEKGIRIFDLE-NKDVIVEL 274 Query: 570 VKRPMKIIKALNAHKDGVNNLLWETPSTLVSSG-ADACIKRWNV 612 + K ++ W + SG D I+ W+V Sbjct: 275 APEAQQKSKKTP----ECMSIAWSADGNTLYSGYTDNVIRVWSV 314 >6HQA-B nrPDB Length = 722 Score = 162 bits (410), Expect = 4e-40, Method: Composition-based stats. Identities = 56/328 (17%), Positives = 106/328 (32%), Gaps = 50/328 (15%) Query: 46 LDDGDSKVPPVVQFTGHG-SSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSV 104 L + +P V +T H ++ +T +KF+ S + SG + + +W Sbjct: 371 LSAAQASLPSVCMYTFHNTNNDLTCLKFN--DDSTMVASGFQDSFIKLWSIDG------- 421 Query: 105 EVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRIN 164 L + + ++ + V R + GHS + Sbjct: 422 --------SPLRSLLKNDPYNQQNNDGVAVKGSR----------------RLVGHSGAVY 457 Query: 165 ACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVIT 224 + +D +V + + S + H S V DV+FSP G + T Sbjct: 458 GVDFSPDNRYLI-SCSEDKTVRLWSLDTYTCLVSYKGH---SSSVWDVKFSP-MGHYFAT 512 Query: 225 VGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTS 284 D+ + L+ V F +S T +D T R+WD+ Sbjct: 513 ASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFH---PNSTYLFTGSSDKTARMWDIARG 569 Query: 285 KCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGH-NKGIT 343 +CV+ + + V+ + S D + +++ +K + GH I Sbjct: 570 ECVRVFMGHSGAIN---CLAVSPDGRWLASAGEDSVVCLWDISTGRRIKAMRGHGRSSIY 626 Query: 344 ALTVNP----LISGSYDGRIMEWSSSSM 367 +L + L+S D + W Sbjct: 627 SLAFSREGTVLVSTGADNSVRVWDVKKN 654 Score = 132 bits (331), Expect = 5e-31, Method: Composition-based stats. Identities = 50/254 (19%), Positives = 92/254 (36%), Gaps = 23/254 (9%) Query: 170 QSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDR 229 P+RS+ D + Q R V V+FSPD+ ++I+ D+ Sbjct: 420 DGSPLRSLLKNDPYN---QQNNDGVAVKGSRRLVGHSGAVYGVDFSPDN-RYLISCSEDK 475 Query: 230 KISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQK 289 + + + L + V F+ FAT D T R+W ++ Sbjct: 476 TVRLWSLDTYTCLVSYKGHSSSVWDVKFSPM---GHYFATASHDQTARLWSCDHIYPLRI 532 Query: 290 WTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP 349 + L + + + + S D T +++ E ++ GH+ I L V+P Sbjct: 533 FAGH---LNDVDCVEFHPNSTYLFTGSSDKTARMWDIARGECVRVFMGHSGAINCLAVSP 589 Query: 350 ----LISGSYDGRIMEWSSSSMHQ------DHSNLIVSLDNSKAQEYS-SISWDDTLKVN 398 L S D + W S+ + + I SL S+ S D++++V Sbjct: 590 DGRWLASAGEDSVVCLWDISTGRRIKAMRGHGRSSIYSLAFSREGTVLVSTGADNSVRVW 649 Query: 399 GITK--HEFGSQPK 410 + K + +QP+ Sbjct: 650 DVKKNTNSPSAQPE 663 Score = 95.8 bits (236), Expect = 4e-20, Method: Composition-based stats. Identities = 47/360 (13%), Positives = 109/360 (30%), Gaps = 67/360 (18%) Query: 241 FLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVT------------------ 282 + + + F DS A+ D+ I++W + Sbjct: 382 CMYTFHNTNNDLTCLKFN---DDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNN 438 Query: 283 TSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGI 342 V+ G + N +IS S D T+ + L L + GH+ + Sbjct: 439 DGVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSV 498 Query: 343 TALTVNP----LISGSYDGRIMEWS-----SSSMHQDHSNLIVSLDNSKAQEYSSISWDD 393 + +P + S+D WS + H N + ++ Y Sbjct: 499 WDVKFSPMGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLFTG--- 555 Query: 394 TLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVS 453 ++ V + AVS Sbjct: 556 ----------SSDKTARMWDIARGECVRVFMGHSGAI-----------------NCLAVS 588 Query: 454 LSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKIL 513 ++A E+ + + ++ +S ++ R+ ++ S T + + + Sbjct: 589 PDGRWLASAGED-SVVCLWDISTGRRIKAMRGHGRSSIYSLAFSREGTVLVSTGADNSVR 647 Query: 514 LYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRP 573 ++D++ T+ + IN ++ + +K + +++VAT + ++ +Y K+ Sbjct: 648 VWDVKK---NTNSPSAQPEPINDVTAQGIQKKTEDLRRRKEIVAT---NDHMSVYFTKKT 701 Score = 84.6 bits (207), Expect = 1e-16, Method: Composition-based stats. Identities = 52/299 (17%), Positives = 105/299 (35%), Gaps = 46/299 (15%) Query: 331 VLKTISGHNKGITALTVN----PLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEY 386 + T N +T L N + SG D I WS S L N + + Sbjct: 382 CMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSI-DGSPLRSLLKNDPYNQQNNDG 440 Query: 387 SSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLN 446 ++ L + + P ++ + + D + + T + S + + Sbjct: 441 VAVKGSRRLVGHSGAVYGVDFSP------DNRYLISCSEDKTVRLWSLDTYTCLVSYKGH 494 Query: 447 SPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKT-----PLRAKPSY------IS 495 S + +G F + + + L + PLR + + Sbjct: 495 SSSV---WDVKFSPMG-------HYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVE 544 Query: 496 ISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDL 555 P+ TY+ G ++D+ E + H+ IN ++ P + Sbjct: 545 FHPNSTYLFTGSSDKTARMWDIARGEC-VRVFMGHSGAINCLAVSPDGRW---------- 593 Query: 556 VATGSLDTNIFIYSVKRPMKIIKALNAH-KDGVNNLLWETPST-LVSSGADACIKRWNV 612 +A+ D+ + ++ + +I KA+ H + + +L + T LVS+GAD ++ W+V Sbjct: 594 LASAGEDSVVCLWDISTGRRI-KAMRGHGRSSIYSLAFSREGTVLVSTGADNSVRVWDV 651 >4V7E-Bg nrPDB Length = 380 Score = 157 bits (395), Expect = 2e-38, Method: Composition-based stats. Identities = 50/339 (14%), Positives = 120/339 (35%), Gaps = 42/339 (12%) Query: 59 FTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGP 118 GH V + ++ S + G++IVW +++++++++ + P Sbjct: 62 LQGHSGKVYS---LDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWVMECAFAP 118 Query: 119 ISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSL-------GEVSGHSQRINACHLKQS 171 V G D+ + S ++GH ++C Sbjct: 119 NGQ----------SVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPD 168 Query: 172 RPMRSMTVGDDGSVVFYQGPPFKFSASDRTH--HKQGSFVRDVEFSPDSGEFVITVGSDR 229 + R +T D + V + + + + + V + + + I+ D Sbjct: 169 QETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDT 228 Query: 230 KISCFDGK-SGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQ 288 + +D + + ++ + + F + D Q+F T D T R++D+ T +Q Sbjct: 229 TVRLWDLRITSRAVRTYHGHEGDINSVKF---FPDGQRFGTGSDDGTCRLFDMRTGHQLQ 285 Query: 289 KWTLDKQQLGNQ---QVGVVATGNGRIISLSL-DGTLNFYELGHDEVLKTIS----GHNK 340 + + + N+ V + +GR++ +G ++ E++ + H Sbjct: 286 VYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQNSHEG 345 Query: 341 GITALTV----NPLISGSYDGRIMEWSSSSMHQDHSNLI 375 I+ L + + L +GS+D + W H ++ Sbjct: 346 RISCLGLSSDGSALCTGSWDKNLKIW----AFSGHRKIV 380 Score = 72.6 bits (176), Expect = 4e-13, Method: Composition-based stats. Identities = 55/368 (14%), Positives = 113/368 (30%), Gaps = 52/368 (14%) Query: 229 RKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQ 288 R F+ + ++ V + + + D + VW+ TS+ + Sbjct: 46 RTAVSFNPTDLVCCRTLQGHSGKVYSLDWT---PEKNWIVSASQDGRLIVWNALTSQ--K 100 Query: 289 KWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDE-------VLKTISGHNKG 341 + + G + LD + + L V + ++GH Sbjct: 101 THAIKLHCPWVMECAFAPNGQS-VACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGY 159 Query: 342 ITALTVNP-----LISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLK 396 ++ P LI+GS D + W ++ Q S + + S+S + +L Sbjct: 160 ASSCQYVPDQETRLITGSGDQTCVLWDVTTG-QRISIFGSEFPSGHTADVLSLSIN-SLN 217 Query: 397 VNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFT----GDIIKSVRLNSPGSAV 452 N + ++ AV T + S G + + Sbjct: 218 ANMFISGSCDTTVRLWDLRITS-RAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLF 276 Query: 453 SLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKI 512 + G+ +QV+ +L P+ + ++ S S + AG G Sbjct: 277 DMRT---------GHQLQVYNREPDRNDNEL--PI---VTSVAFSISGRLLFAGYSNGDC 322 Query: 513 LLYDLQSREVKTSRWAF---HTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYS 569 ++D E+ + H +I+ + + TGS D N+ I++ Sbjct: 323 YVWDTLLAEMVLNLGTLQNSHEGRISCLGLSSDGSA----------LCTGSWDKNLKIWA 372 Query: 570 VKRPMKII 577 KI+ Sbjct: 373 FSGHRKIV 380 Score = 53.8 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 35/216 (16%), Positives = 86/216 (39%), Gaps = 27/216 (12%) Query: 406 GSQPKVAS---ANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGS---AVSLSQNYV 459 G KV S + + D L++ + T +++L+ P A + + V Sbjct: 64 GHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWVMECAFAPNGQSV 123 Query: 460 AVGLEEG--NTIQVFKLSDLEVSFDLKTPLRAKPSYIS---ISPS-ETYIAAGDVMGKIL 513 A G + + + +D + + + L Y S P ET + G + Sbjct: 124 ACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSGDQTCV 183 Query: 514 LYDLQSREVKTSRW-----AFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIY 568 L+D+ + + + S + + HT+ + ++S + ++ +GS DT + ++ Sbjct: 184 LWDVTTGQ-RISIFGSEFPSGHTADVLSLSINS---------LNANMFISGSCDTTVRLW 233 Query: 569 SVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSGAD 604 ++ + ++ + H+ +N++ + +G+D Sbjct: 234 DLRITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSD 269 >6ID0-T nrPDB Length = 514 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 55/251 (21%), Positives = 99/251 (39%), Gaps = 21/251 (8%) Query: 156 VSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFS 215 +SGH + ++ +T D ++ + K S H S VR V S Sbjct: 200 ISGHLGWVRCIAVEPG-NQWFVTGSADRTIKIWDLASGKLKLSLTGHI---STVRGVIVS 255 Query: 216 PDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADAT 275 ++ + G D+++ C+D + + +++ V G + T D+T Sbjct: 256 T-RSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTI---DVLVTCSRDST 311 Query: 276 IRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTI 335 R+WDV T V TL V A +II+ S D T+ ++L + T+ Sbjct: 312 ARIWDVRTKASVH--TLSGHTNAVATVRCQA-AEPQIITGSHDTTIRLWDLVAGKTRVTL 368 Query: 336 SGHNKGITALTVNP----LISGSYDGRIMEW-----SSSSMHQDHSNLIVSLDNSKAQEY 386 + H K + A+ ++P SGS D I +W S H+ +I +L + Sbjct: 369 TNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVL 427 Query: 387 SSISWDDTLKV 397 S + + T+ + Sbjct: 428 VSGADNGTMHL 438 Score = 118 bits (294), Expect = 9e-27, Method: Composition-based stats. Identities = 46/331 (13%), Positives = 100/331 (30%), Gaps = 42/331 (12%) Query: 59 FTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGP 118 +GH V + P G+Q+ +G + +W +K Sbjct: 200 ISGHLGWVRC-IAVEP--GNQWFVTGSADRTIKIWDLA--------SGKLKLSLTGHIST 248 Query: 119 ISDISWDFEGRRLCVVGEGRDNFGVFISWD--SGNSLGEVSGHSQRINACHLKQSRPMRS 176 + + L GE + WD + GH + L + + Sbjct: 249 VRGVIVSTRSPYLFSCGEDKQ----VKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLV 304 Query: 177 MTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDG 236 T D + + + H + VR P +IT D I +D Sbjct: 305 -TCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEP----QIITGSHDTTIRLWDL 359 Query: 237 KSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQ 296 +G+ + + ++ V+ + FA+ D I+ W +Q + Sbjct: 360 VAGKTRVTLTNHKKSVRAVVLHPRHYT---FASGSPDN-IKQWKFPDGSFIQNLSGHNAI 415 Query: 297 LGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISG--------HNKGITALTV- 347 + + +G ++S + +GT++ ++ + + GI A Sbjct: 416 IN----TLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFD 471 Query: 348 ---NPLISGSYDGRIMEWSSSSMHQDHSNLI 375 + L++ D I + + ++ + Sbjct: 472 QSESRLLTAEADKTIKVYREDDTATEETHPV 502 Score = 74.2 bits (180), Expect = 2e-13, Method: Composition-based stats. Identities = 46/300 (15%), Positives = 102/300 (34%), Gaps = 24/300 (8%) Query: 288 QKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTV 347 + + + LG + V GN ++ S D T+ ++L ++ +++GH + + V Sbjct: 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIV 254 Query: 348 NP----LISGSYDGRIMEWSS-----SSMHQDHSNLIVSLDNSKAQEYS-SISWDDTLKV 397 + L S D ++ W + H + + LD + + S D T ++ Sbjct: 255 STRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314 Query: 398 -----NGITKHEFGSQPKVASA---NNDGFTAVLTNDDDLLILQSFTGDI-IKSVRLNSP 448 G VA+ + ++D + + G + Sbjct: 315 WDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKS 374 Query: 449 GSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDV 508 AV L + + I+ +K D +L + A + ++++ + +G Sbjct: 375 VRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNL-SGHNAIINTLTVNSDGV-LVSGAD 432 Query: 509 MGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIY 568 G + L+D ++ + H + + A + E + T D I +Y Sbjct: 433 NGTMHLWDWRT---GYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489 Score = 52.6 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 48/288 (16%), Positives = 88/288 (30%), Gaps = 48/288 (16%) Query: 330 EVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQE 385 ++ + ISGH + + V P ++GS D I W +S S + ++ Sbjct: 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLS--LTGHISTVRGV 252 Query: 386 YSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLL--ILQSFTGDIIKSV 443 S Q K + + + T D++ + Sbjct: 253 IVSTRSPYLFSCGE------DKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTC 306 Query: 444 RLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYI 503 +S + + +V G+T V + + +E I Sbjct: 307 SRDSTARIWDV-RTKASVHTLSGHTNAV--------------------ATVRCQAAEPQI 345 Query: 504 AAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDT 563 G I L+DL + + + H + A+ P A+GS D Sbjct: 346 ITGSHDTTIRLWDLVAGKTRV-TLTNHKKSVRAVVLHP----------RHYTFASGSPD- 393 Query: 564 NIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSGADACIKRWN 611 NI + I+ L+ H +N L + LVS + + W+ Sbjct: 394 NIKQWKFPDGS-FIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWD 440 Score = 50.3 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 29/166 (17%), Positives = 65/166 (39%), Gaps = 15/166 (9%) Query: 449 GSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDV 508 AV + G + TI+++ L+ ++ L + + + +S Y+ + Sbjct: 209 CIAVEPGNQWFVTGSAD-RTIKIWDLASGKLKLSLTGHI-STVRGVIVSTRSPYLFSCGE 266 Query: 509 MGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIY 568 ++ +DL+ +V + H S + + P D++ T S D+ I+ Sbjct: 267 DKQVKCWDLEYNKV-IRHYHGHLSAVYGLDLHPTI----------DVLVTCSRDSTARIW 315 Query: 569 SVKRPMKIIKALNAHKDGVNNL-LWETPSTLVSSGADACIKRWNVV 613 V R + L+ H + V + +++ D I+ W++V Sbjct: 316 DV-RTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV 360 >3JAP-g nrPDB Length = 326 Score = 156 bits (393), Expect = 3e-38, Method: Composition-based stats. Identities = 51/266 (19%), Positives = 103/266 (38%), Gaps = 28/266 (10%) Query: 153 LGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQG--PPFKFSASDRTHHKQGSFVR 210 G + GH+ + + ++P ++ D +++ ++ +F R++ V+ Sbjct: 11 RGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQ 70 Query: 211 DVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATV 270 DV S D G + ++ D+ + ++ +G V +S K + Sbjct: 71 DVVVSAD-GNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAID---ANSSKIISA 126 Query: 271 GADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVAT-------GNGRI--ISLSLDGTL 321 D TIRVW+ T C + L +V V +GRI +S +D + Sbjct: 127 SRDKTIRVWN-TVGDCA--YVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIV 183 Query: 322 NFYELG--HDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWS----SSSMHQDH 371 + L + GHN I + +P S DG+I W+ S+ M+ D Sbjct: 184 RSWSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMNFDA 243 Query: 372 SNLIVSLDNSKAQEYSSISWDDTLKV 397 + + +L S ++ + + + +K+ Sbjct: 244 KDEVFALAFSPSRFWLTAATASGIKI 269 Score = 95.8 bits (236), Expect = 5e-20, Method: Composition-based stats. Identities = 33/224 (14%), Positives = 74/224 (33%), Gaps = 33/224 (14%) Query: 196 SASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGE-----FLKYIEDDQE 250 T +V + S +++ D+ + + E ++ + Sbjct: 8 LVLRGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSH 67 Query: 251 PVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNG 310 VQ + + D + D T+R+W++ T ++ + + + ++ Sbjct: 68 IVQDVVVS---ADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSS--- 121 Query: 311 RIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP--------------LISGSYD 356 +IIS S D T+ + + + GH +T + V P +S D Sbjct: 122 KIISASRDKTIRVWNTV-GDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMD 180 Query: 357 GRIMEWSSS-------SMHQDHSNLIVSLDNSKAQEYSSISWDD 393 + WS + + H+N I + S ++ + D Sbjct: 181 KIVRSWSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKD 224 Score = 92.7 bits (228), Expect = 4e-19, Method: Composition-based stats. Identities = 51/333 (15%), Positives = 108/333 (32%), Gaps = 45/333 (13%) Query: 59 FTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGP 118 GH V T++ S + + L SG +I W T +++ V V ++ + Sbjct: 14 LEGHNGWV-TSLSTSAAQPN-LLVSGSRDKTLISWRLTENEQQFGVPV---RSYKGHSHI 68 Query: 119 ISDISWDFEGRRLCVVGEGRDNFGVFISWD--SGNSLGEVSGHSQRINACHLKQSRPMRS 176 + D+ +G + W+ +GNS GH+ + + + + + Sbjct: 69 VQDVVVSADGNYAVSASWDK----TLRLWNLATGNSEARFVGHTGDVLSVAIDANS-SKI 123 Query: 177 MTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSP---------DSGEFVITVGS 227 ++ D ++ + +V V +P D ++ G Sbjct: 124 ISASRDKTIRVWN----TVGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGM 179 Query: 228 DRKISCFDGKSGEFLKYIEDDQEPVQGGIFAL-SWLDSQKFATVGADATIRVWDVTTSKC 286 D+ + + E IE D I + D A+ G D I VW++ Sbjct: 180 DKIVRSWSL--NEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSA 237 Query: 287 VQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGH----DEVLKTISGHNKG- 341 + ++ + + + ++ + + Y+L + DE+ +G+ K Sbjct: 238 FMNF-----DAKDEVFALAFSPSRFWLTAATASGIKIYDLENEVLIDELKPEFAGYTKAQ 292 Query: 342 -------ITALTVNPLISGSYDGRIMEWSSSSM 367 + L +G D I W + Sbjct: 293 DPHAVSLAWSADGQTLFAGYTDNVIRVWQVMTA 325 Score = 77.3 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 42/235 (17%), Positives = 77/235 (32%), Gaps = 18/235 (7%) Query: 58 QFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAG 117 +F GH V++ S + S + VW D + + + +V Sbjct: 103 RFVGHTGDVLSVAI---DANSSKIISASRDKTIRVWNTVGDC-AYVLLGHTDWVTKVRVA 158 Query: 118 PISDISWDFEGRRL--CVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMR 175 P + + + R+ G + ++ DS + GH+ IN Sbjct: 159 PKNLEDGEVDDGRITFVSAGMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQPSPDG-SL 217 Query: 176 SMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFD 235 + + G DG + + K ++ V + FSP F +T + I +D Sbjct: 218 AASAGKDGQIYVWNL---KHKSAFMNFDA-KDEVFALAFSP--SRFWLTAATASGIKIYD 271 Query: 236 GKSGEFLKY----IEDDQEPVQGGIFALSW-LDSQKFATVGADATIRVWDVTTSK 285 ++ + + +L+W D Q D IRVW V T+ Sbjct: 272 LENEVLIDELKPEFAGYTKAQDPHAVSLAWSADGQTLFAGYTDNVIRVWQVMTAN 326 Score = 62.6 bits (150), Expect = 5e-10, Method: Composition-based stats. Identities = 48/336 (14%), Positives = 118/336 (35%), Gaps = 38/336 (11%) Query: 291 TLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEV-----LKTISGHN----KG 341 TL+ + A ++S S D TL + L +E +++ GH+ Sbjct: 13 TLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDV 72 Query: 342 ITALTVNPLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGIT 401 + + N +S S+D + W+ ++ + + + + S++ D + I Sbjct: 73 VVSADGNYAVSASWDKTLRLWNLATGNSEARFV------GHTGDVLSVAIDANS--SKII 124 Query: 402 KHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAV 461 +V + D +L + D + ++ ++ + + VS + + Sbjct: 125 SASRDKTIRVWNTVGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKI-- 182 Query: 462 GLEEGNTIQVFKLSDLEVSFDLKTPLRAK-PSYISISPSETYIAAGDVMGKILLYDLQSR 520 ++ + L++ + + + SP + A+ G+I +++L+ Sbjct: 183 -------VRSWSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLK-- 233 Query: 521 EVKTSRWAFHTSK--INAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIK 578 S + +K + A+++ P+ + L+ + I +K + Sbjct: 234 --HKSAFMNFDAKDEVFALAFSPSRFWLTAATASGIKIY--DLENEVLIDELKP--EFAG 287 Query: 579 ALNAHKDGVNNLLWETPSTLVSSG-ADACIKRWNVV 613 A +L W + +G D I+ W V+ Sbjct: 288 YTKAQDPHAVSLAWSADGQTLFAGYTDNVIRVWQVM 323 >5WYJ-BC nrPDB Length = 817 Score = 156 bits (393), Expect = 3e-38, Method: Composition-based stats. Identities = 49/270 (18%), Positives = 104/270 (38%), Gaps = 28/270 (10%) Query: 112 FQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVS----GHSQRINACH 167 ++ ++ + +G + +DN + ++ + ++ GHS + A Sbjct: 384 YEGHEDLLNSLDATEDGLWIATAS--KDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVG 441 Query: 168 L----KQSRPMRSMTVGDDGSVVFYQGPPFK-------FSASDRTHHKQGSFVRDVEFSP 216 L + P +T +D ++ + P S+ T H + + SP Sbjct: 442 LPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSP 501 Query: 217 DSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATI 276 + F T D+ ++ ++GE + + + + F + AT D T+ Sbjct: 502 NDSIFA-TASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQYD---KLLATSSGDKTV 557 Query: 277 RVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTIS 336 ++W + T ++ TL+ Q+ + ++IS DG + ++ E LKT+ Sbjct: 558 KIWSLDTFSVMK--TLEGHTNAVQRCSFI-NKQKQLISCGADGLIKIWDCSSGECLKTLD 614 Query: 337 GHNKGITALTV----NPLISGSYDGRIMEW 362 GHN + AL+ + ++S DG W Sbjct: 615 GHNNRLWALSTMNDGDMIVSADADGVFQFW 644 Score = 103 bits (255), Expect = 3e-22, Method: Composition-based stats. Identities = 103/614 (16%), Positives = 218/614 (35%), Gaps = 95/614 (15%) Query: 43 VRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESN 102 + +D + + + +T +K +P QYL ++ + ++ K Sbjct: 40 INIIDLTPGSRKILHKISNEDEQEITALKLTP--DGQYLTYVSQAQLLKIFHLKTGKVVR 97 Query: 103 SVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQR 162 S++ ++ P + D L V G D + + ++G GH Sbjct: 98 SMK---------ISSPSYILDADSTSTLLAVGGT--DGSIIVVDIENGYITHSFKGHGGT 146 Query: 163 INACHLKQSRPMRS-MTVGDD--GSVVFYQGPPFKFSASDRTHHK--QGSFVRDVEFSPD 217 I++ + + D G V + K + + H +G + +V + + Sbjct: 147 ISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEVPDNDE 206 Query: 218 SGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWL---DSQKF-ATVGAD 273 +++ G D I+ +D K PV + + +L D ++ T G D Sbjct: 207 PSLNLLSGGRDDIINLWDF--NMKKKCKLLKTLPVNQQVESCGFLKDGDGKRIIYTAGGD 264 Query: 274 ATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELG------ 327 A ++ D + +++ ++L V + + + + LS D TL + Sbjct: 265 AIFQLIDSESGSVLKRTNKPIEELFIIGVLPILSNSQMFLVLS-DQTLQLINVEEDLKND 323 Query: 328 --HDEVLKTISGHNKGITALT-VNP------LISGSYDGRIMEWSSSSM----------- 367 +V +I+G++ I + V P L + S RI+ S Sbjct: 324 EDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIPVPDLSGPEASLPLDVEI 383 Query: 368 HQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDD 427 ++ H +L+ SLD ++ + + + + V N + Sbjct: 384 YEGHEDLLNSLDATEDGLWIATA-------------SKDNTAIVWRYNENSCK------- 423 Query: 428 DLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPL 487 I + G +V + VS + TI+ + + S D++ Sbjct: 424 -FDIYAKYIGH-SAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIK 481 Query: 488 RAK---------PSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAIS 538 ++ + +S+SP+++ A +++L++ E++ + A H + +S Sbjct: 482 VSEYTRHAHEKDINALSVSPNDSIFATASYDKTCKIWNLENGELE-ATLANHKRGLWDVS 540 Query: 539 WKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPST- 597 + +K L+AT S D + I+S+ ++K L H + V + Sbjct: 541 FCQYDK----------LLATSSGDKTVKIWSLD-TFSVMKTLEGHTNAVQRCSFINKQKQ 589 Query: 598 LVSSGADACIKRWN 611 L+S GAD IK W+ Sbjct: 590 LISCGADGLIKIWD 603 Score = 86.5 bits (212), Expect = 3e-17, Method: Composition-based stats. Identities = 78/523 (14%), Positives = 170/523 (32%), Gaps = 88/523 (16%) Query: 165 ACHLKQSRPMRSMTVGDDGSVV---------FYQGPPFKFSASDRTHHKQGSFVRDVEFS 215 + + + TV ++G ++ P + ++ + ++ + Sbjct: 11 SLNPIYAGSSAVATVSENGKILATPVLDEINIIDLTPGSRKILHKISNEDEQEITALKLT 70 Query: 216 PDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADAT 275 PD G+++ V + + F K+G+ ++ ++ + S L A G D + Sbjct: 71 PD-GQYLTYVSQAQLLKIFHLKTGKVVRSMKISSPSYILDADSTSTL----LAVGGTDGS 125 Query: 276 IRVWDVTTSKCVQKWTLDKQQLGN-QQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKT 334 I V D+ + + + + G + + + S +G + ++L + L T Sbjct: 126 IIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKCLHT 185 Query: 335 ISGHNKGITALTV-------NP---LISGSYDGRIMEWSSSSMH----------QDHSNL 374 + H + L + P L+SG D I W + Sbjct: 186 LQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLLKTLPVNQQVES 245 Query: 375 IVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANND-----GFTAVLTNDDDL 429 L + + + D + + E GS K + + G +L+N Sbjct: 246 CGFLKDGDGKRIIYTAGGDA--IFQLIDSESGSVLKRTNKPIEELFIIGVLPILSNSQMF 303 Query: 430 LILQSFTGDII----------KSVRLNSPGS---AVSLSQNYV------AVGLEEGNTIQ 470 L+L T +I ++++ S + + YV +++ Sbjct: 304 LVLSDQTLQLINVEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLR 363 Query: 471 VFKLSDLEVSFDLKTPLRAKP--------SYISISPSETYIAAGDVMGKILLYDLQSREV 522 + + DL + PL + + + + +IA +++ Sbjct: 364 IIPVPDLS-GPEASLPLDVEIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSC 422 Query: 523 KTSRWA---FHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPM----- 574 K +A H++ + A+ E + T S D I + + +P Sbjct: 423 KFDIYAKYIGHSAAVTAVGLPNIVSKGYPE-----FLLTASNDLTIKKWIIPKPTASMDV 477 Query: 575 KIIKAL----NAHKDGVNNLLWE-TPSTLVSSGADACIKRWNV 612 +IIK +AH+ +N L S ++ D K WN+ Sbjct: 478 QIIKVSEYTRHAHEKDINALSVSPNDSIFATASYDKTCKIWNL 520 Score = 85.7 bits (210), Expect = 6e-17, Method: Composition-based stats. Identities = 90/560 (16%), Positives = 176/560 (31%), Gaps = 103/560 (18%) Query: 58 QFTGHGSSVVTTVKFSPIKGSQ--YLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVL 115 F GHG ++ +++KF S+ L SGD +G V VW V+ Q Sbjct: 139 SFKGHGGTI-SSLKFYGQLNSKIWLLASGDTNGMVKVWDL--------VKRKCLHTLQEH 189 Query: 116 AGPISDISW----DFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRIN----ACH 167 + + D + L ++ GRD+ + WD + +N +C Sbjct: 190 TSAVRGLDIIEVPDNDEPSLNLLSGGRDD--IINLWDFNMKKKCKLLKTLPVNQQVESCG 247 Query: 168 L-KQSRPMRSM-TVGDDGSVVFYQGPPFKFSASDRTHHK--QGSFVRDVEFSPDSGEFVI 223 K R + T G D +Q + + + +K + F+ V + + + Sbjct: 248 FLKDGDGKRIIYTAGGD---AIFQLIDSESGSVLKRTNKPIEELFIIGVLPILSNSQMFL 304 Query: 224 TVGSDRKISCF----DGKSGEFLKYIEDDQEPVQGGIFALSW--LDSQKFATVGADATIR 277 + D+ + D K+ E + G I + + + K A ++R Sbjct: 305 VLS-DQTLQLINVEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLR 363 Query: 278 VWDVTTSK--------CVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHD 329 + V V+ + + L + I + S D T + + Sbjct: 364 IIPVPDLSGPEASLPLDVEIYEGHEDLLNSLDATE---DGLWIATASKDNTAIVWRYNEN 420 Query: 330 EVL----KTISGHNKGITALTVNPLIS---------GSYDGRIMEWSSSSMHQDHSNLIV 376 GH+ +TA+ + ++S S D I +W I+ Sbjct: 421 SCKFDIYAKYIGHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQII 480 Query: 377 SL------DNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLL 430 + + K S+S +D++ + K+ + N A L N L Sbjct: 481 KVSEYTRHAHEKDINALSVSPNDSIFATA----SYDKTCKIWNLENGELEATLANHKRGL 536 Query: 431 ILQSF--TGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLR 488 SF ++ + + SL + + EG+T V + S Sbjct: 537 WDVSFCQYDKLLATSSGDKTVKIWSLD-TFSVMKTLEGHTNAVQRCS------------- 582 Query: 489 AKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANE 548 + + + G I ++D S E H +++ A+S Sbjct: 583 -------FINKQKQLISCGADGLIKIWDCSSGEC-LKTLDGHNNRLWALS---------- 624 Query: 549 EEIEEDLVATGSLDTNIFIY 568 + D++ + D + Sbjct: 625 TMNDGDMIVSADADGVFQFW 644 Score = 31.0 bits (68), Expect = 1.7, Method: Composition-based stats. Identities = 21/197 (10%), Positives = 52/197 (26%), Gaps = 26/197 (13%) Query: 59 FTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGP 118 GH ++ V F I + L S G + +W + Sbjct: 571 LEGH-TNAVQRCSF--INKQKQLISCGADGLIKIWDCS--------SGECLKTLDGHNNR 619 Query: 119 ISDISWDFEGRRLCVVGEG------RDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSR 172 + +S +G + +D I + + +V N Sbjct: 620 LWALSTMNDGDMIVSADADGVFQFWKDCTEQEIEEEQEKAKLQVEQEQSLQNYMSKGDWT 679 Query: 173 PMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSD---- 228 + + D + + S + + V F+ + + I++ +D Sbjct: 680 NAFLLAMTLDHPMRLFNVLKRALGESRSRQDTEEGKIE-VIFNEEL-DQAISILNDEQLI 737 Query: 229 ---RKISCFDGKSGEFL 242 ++ ++ + Sbjct: 738 LLMKRCRDWNTNAKTHT 754 >6Q8F-A nrPDB Length = 514 Score = 151 bits (382), Expect = 6e-37, Method: Composition-based stats. Identities = 67/345 (19%), Positives = 133/345 (38%), Gaps = 34/345 (9%) Query: 183 GSVVFYQGPPFKFSASDRTHHK--QGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGE 240 G KF H K Q S V FSPD G++++T D I ++ +G+ Sbjct: 190 GKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPD-GQYLVTGSVDGFIEVWNFTTGK 248 Query: 241 FLKYI----EDDQEPVQGGIFALSW-LDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQ 295 K + +D+ + + + + D++ AT D I+VW + + +C++++ ++ Sbjct: 249 IRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRF--ERA 306 Query: 296 QLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTV----NPLI 351 + + +I+S S D T+ + L + LK GH+ + T + +I Sbjct: 307 HSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYII 366 Query: 352 SGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKV 411 S S DG + W+ + + SN SL ++ + + VN + P+ Sbjct: 367 SASSDGTVKIWNMKTT--ECSNTFKSLGSTAGTD---------ITVNSVIL--LPKNPEH 413 Query: 412 ASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQV 471 N T V+ N ++ +G + A+S ++ E+ + Sbjct: 414 FVVCNRSNTVVIMNMQGQIVRSFSSGK---REGGDFVCCALSPRGEWIYCVGED---FVL 467 Query: 472 FKLSDLEVSFDLKTPLRAK-PSYISISPSETYIAAGDVMGKILLY 515 + S + + + K I+ P + IA G + L+ Sbjct: 468 YCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 512 Score = 109 bits (271), Expect = 5e-24, Method: Composition-based stats. Identities = 58/395 (14%), Positives = 120/395 (30%), Gaps = 76/395 (19%) Query: 34 AYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDE----SGK 89 AYP G S R + V + + L G GK Sbjct: 132 AYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGK 191 Query: 90 VIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDS 149 V +K + ++K + + + +G+ L D F ++ + Sbjct: 192 AAVKDVEEEKFPTQLSRHIKFGQKSH---VECARFSPDGQYLVTGSV--DGFIEVWNFTT 246 Query: 150 GNSLGEVSGHSQ--------RINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRT 201 G ++ +Q + + M + T DG + ++ + Sbjct: 247 GKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLA-TGAQDGKIKVWKIQSGQCLRRFER 305 Query: 202 HHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSW 261 V + FS DS + +++ D+ I KSG+ LK V F Sbjct: 306 --AHSKGVTCLSFSKDSSQ-ILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFT--- 359 Query: 262 LDSQKFATVGADATIRVWDVTTSKC----------------------------------- 286 D + +D T+++W++ T++C Sbjct: 360 QDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNR 419 Query: 287 -------------VQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLK 333 V+ ++ K++ G+ ++ I + D L + ++ + Sbjct: 420 SNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLER 479 Query: 334 TISGHNKGITALTVNP----LISGSYDGRIMEWSS 364 T++ H K + + +P + + S DG + W Sbjct: 480 TLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP 514 Score = 46.1 bits (107), Expect = 5e-05, Method: Composition-based stats. Identities = 25/132 (18%), Positives = 57/132 (43%), Gaps = 4/132 (3%) Query: 478 EVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAI 537 ++S +K ++ SP Y+ G V G I +++ + K + + ++ N + Sbjct: 205 QLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTT--GKIRKDLKYQAQDNFM 262 Query: 538 SWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPST 597 + +++ATG+ D I ++ ++ + + AH GV L + S+ Sbjct: 263 MMD-DAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSS 321 Query: 598 -LVSSGADACIK 608 ++S+ D I+ Sbjct: 322 QILSASFDQTIR 333 Score = 45.7 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 36/246 (14%), Positives = 74/246 (30%), Gaps = 40/246 (16%) Query: 337 GHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQDHSNLIVSLDN----SKAQEYSS 388 G + +P L++GS DG I W+ ++ + DN A Sbjct: 213 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMC 272 Query: 389 ISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSP 448 S D + G + KV + G S +S Sbjct: 273 FSRDTEMLATGAQ----DGKIKVWKIQSGQCLR-------RFERAHSKGVTCLSFSKDSS 321 Query: 449 -GSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGD 507 + S Q GL+ G T++ F+ V + + + YI + Sbjct: 322 QILSASFDQTIRIHGLKSGKTLKEFRGHSSFV------------NEATFTQDGHYIISAS 369 Query: 508 VMGKILLYDLQSREVKTSRWA--FHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNI 565 G + ++++++ E ++ + T+ + N E + + Sbjct: 370 SDGTVKIWNMKTTEC-SNTFKSLGSTAGTDITVNSVILLPKNPEH-----FVVCNRSNTV 423 Query: 566 FIYSVK 571 I +++ Sbjct: 424 VIMNMQ 429 >5Z56-q nrPDB Length = 504 Score = 149 bits (376), Expect = 3e-36, Method: Composition-based stats. Identities = 56/327 (17%), Positives = 112/327 (34%), Gaps = 50/327 (15%) Query: 202 HHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSW 261 H + ++ P ++T G+D+ + FD S + L ++ + V +F S Sbjct: 217 HSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQ 276 Query: 262 LDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTL 321 + DATIR+W V + CVQ + + + + ATG+ ++S S D Sbjct: 277 ---DLVFSASPDATIRIWSVPNASCVQ--VVRAHESAVTGLSLHATGD-YLLSSSDDQYW 330 Query: 322 NFYELGHDEVLKTISGHNKGI--TALTVNP----LISGSYDGRIMEWS-----SSSMHQD 370 F ++ VL ++ G T +P +G+ D +I W + + Sbjct: 331 AFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPG 390 Query: 371 HSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLL 430 HS I S+ S+ Y + + D S K+ L D++ Sbjct: 391 HSGPITSIAFSENGYYLATAAD-------------DSSVKLWDLRKLKNFKTLQLDNNFE 437 Query: 431 ILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAK 490 + + A+ + + + + + + S L Sbjct: 438 VKSLIFDQ-------SGTYLALGGTDVQIYICKQWTEILHFTEHSGLT------------ 478 Query: 491 PSYISISPSETYIAAGDVMGKILLYDL 517 + ++ +IA+ + + Y L Sbjct: 479 -TGVAFGHHAKFIASTGMDRSLKFYSL 504 Score = 102 bits (253), Expect = 6e-22, Method: Composition-based stats. Identities = 44/242 (18%), Positives = 89/242 (36%), Gaps = 20/242 (8%) Query: 163 INACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFV 222 I A L S + +T G D +VV + + A+ + H K+ V V F P S + V Sbjct: 224 ILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKK---VTSVVFHP-SQDLV 279 Query: 223 ITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVT 282 + D I + + ++ + + V G + + D D+ Sbjct: 280 FSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHAT---GDYLLSSSDDQYWAFSDIQ 336 Query: 283 TSKCVQKWTLDKQQLGNQQVGVVATGNGRII-SLSLDGTLNFYELGHDEVLKTISGHNKG 341 T + + K T + G +G I + ++D + ++L + GH+ Sbjct: 337 TGRVLTKVTDETS--GCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGP 394 Query: 342 ITALTVNP----LISGSYDGRIMEWSSSSMHQ------DHSNLIVSLDNSKAQEYSSISW 391 IT++ + L + + D + W + D++ + SL ++ Y ++ Sbjct: 395 ITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGG 454 Query: 392 DD 393 D Sbjct: 455 TD 456 Score = 47.2 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 25/175 (14%), Positives = 51/175 (29%), Gaps = 28/175 (16%) Query: 67 VTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDF 126 +T +F P +G ++ +W E + F +GPI+ I++ Sbjct: 353 LTCAQFHP--DGLIFGTGTMDSQIKIWDLK--------ERTNVANFPGHSGPITSIAFSE 402 Query: 127 EGRRLCVVGEGRDNFGVFISWD--SGNSLGEVSGHSQR-INACHLKQSRPMRSMTVGDDG 183 G L + WD + + + + + QS ++ D Sbjct: 403 NGYYLATAADD----SSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD-- 456 Query: 184 SVVFYQGPPFKFSASDRTHH--KQGSFVRDVEFSPDSGEFVITVGSDRKISCFDG 236 + H + V F +F+ + G DR + + Sbjct: 457 ------VQIYICKQWTEILHFTEHSGLTTGVAFG-HHAKFIASTGMDRSLKFYSL 504 Score = 45.3 bits (105), Expect = 7e-05, Method: Composition-based stats. Identities = 27/192 (14%), Positives = 66/192 (34%), Gaps = 37/192 (19%) Query: 455 SQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILL 514 N + G + N + VF S ++ LK + K + + PS+ + + I + Sbjct: 233 DTNKILTGGADKNVV-VFDKSSEQILATLKGHTK-KVTSVVFHPSQDLVFSASPDATIRI 290 Query: 515 YDLQS---------REVKTSRWAFHTSKINAISWKPAEKGANEE---------------- 549 + + + E + + H + +S + A + Sbjct: 291 WSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSG 350 Query: 550 --------EIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPS-TLVS 600 + + TG++D+ I I+ +K + H + ++ + L + Sbjct: 351 CSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVA-NFPGHSGPITSIAFSENGYYLAT 409 Query: 601 SGADACIKRWNV 612 + D+ +K W++ Sbjct: 410 AADDSSVKLWDL 421 >5Y88-O nrPDB Length = 451 Score = 148 bits (374), Expect = 5e-36, Method: Composition-based stats. Identities = 49/250 (19%), Positives = 99/250 (39%), Gaps = 22/250 (8%) Query: 156 VSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFS 215 ++GH + + +T +D ++ + K T VRDV S Sbjct: 135 INGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKT---TLAGHVMTVRDVAVS 191 Query: 216 PDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADAT 275 D ++ +V D+ + C+D + + ++ V+ + AT G D+ Sbjct: 192 -DRHPYLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTL---DLIATAGRDSV 247 Query: 276 IRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTI 335 I++WD+ T V K + Q V + +++S S D T+ +++ + +K + Sbjct: 248 IKLWDMRTRIPVITLVGHKGPINQVQCTPV---DPQVVSSSTDATVRLWDVVAGKTMKVL 304 Query: 336 SGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQ--EYSSI 389 + H + + A ++P + S D I W + +L+ + ++ K SI Sbjct: 305 THHKRSVRATALHPKEFSVASACTDD-IRSWGLAEG-----SLLTNFESEKTGIINTLSI 358 Query: 390 SWDDTLKVNG 399 + DD L G Sbjct: 359 NQDDVLFAGG 368 Score = 110 bits (273), Expect = 3e-24, Method: Composition-based stats. Identities = 42/300 (14%), Positives = 99/300 (33%), Gaps = 21/300 (7%) Query: 200 RTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFAL 259 R + +VR V P E+ IT +D + +D +G+ + V+ + Sbjct: 133 RVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDVAVSD 192 Query: 260 SWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDG 319 +V D T++ WD+ ++ ++ + G + V + T + I + D Sbjct: 193 RHP---YLFSVSEDKTVKCWDLEKNQIIRDY--YGHLSGVRTVSIHPTLD-LIATAGRDS 246 Query: 320 TLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMH-----QD 370 + +++ + T+ GH I + P ++S S D + W + Sbjct: 247 VIKLWDMRTRIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMKVLTH 306 Query: 371 HSNLIVSLDNSKAQEYSSISWDDTLK------VNGITKHEFGSQPKVASANNDGFTAVLT 424 H + + + + + D ++ + +T E + + + + + Sbjct: 307 HKRSVRATALHPKEFSVASACTDDIRSWGLAEGSLLTNFESEKTGIINTLSINQDDVLFA 366 Query: 425 NDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLK 484 D+ ++ K L + SL + T + + S + Sbjct: 367 GGDNGVLSFYDYKSGHKYQSLATREMVGSLEGERSVLCSTFDKTGLRLITGEADKSIKIW 426 Score = 105 bits (261), Expect = 7e-23, Method: Composition-based stats. Identities = 50/316 (15%), Positives = 103/316 (32%), Gaps = 40/316 (12%) Query: 61 GHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPIS 120 GH V V P+ +++ +G + VW +K+ + Sbjct: 137 GHLGWVRC-VAIDPV-DNEWFITGSNDTTMKVWDLA--------TGKLKTTLAGHVMTVR 186 Query: 121 DISWDFEGRRLCVVGEGRDNFGVFISWD--SGNSLGEVSGHSQRINACHLKQSRPMRSMT 178 D++ L V E + WD + + GH + + + T Sbjct: 187 DVAVSDRHPYLFSVSEDK----TVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLD-LIAT 241 Query: 179 VGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKS 238 G D + + + H + V+ P V++ +D + +D + Sbjct: 242 AGRDSVIKLWDMRTRIPVITLVGHKGPINQVQCTPVDP----QVVSSSTDATVRLWDVVA 297 Query: 239 GEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLG 298 G+ +K + + V+ A+ D IR W + + + +K + Sbjct: 298 GKTMKVLTHHKRSVRATALHPKEF---SVASACTDD-IRSWGLAEGSLLTNFESEKTGII 353 Query: 299 NQQVGVVATGNGRIISLSLDGTLNFYE---------LGHDEVLKTISGHNKGITAL---T 346 N + + + + +G L+FY+ L E++ ++ G + + T Sbjct: 354 N---TLSINQDDVLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEGERSVLCSTFDKT 410 Query: 347 VNPLISGSYDGRIMEW 362 LI+G D I W Sbjct: 411 GLRLITGEADKSIKIW 426 Score = 70.0 bits (169), Expect = 3e-12, Method: Composition-based stats. Identities = 48/306 (15%), Positives = 105/306 (34%), Gaps = 29/306 (9%) Query: 290 WTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP 349 ++ + V + N I+ S D T+ ++L ++ T++GH + + V+ Sbjct: 133 RVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDVAVSD 192 Query: 350 ----LISGSYDGRIMEWSSSSM--HQDHSNLIVSLDN-----------SKAQEYSSISWD 392 L S S D + W +D+ + + + ++ WD Sbjct: 193 RHPYLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLDLIATAGRDSVIKLWD 252 Query: 393 DTLKVNGITKHEFGSQP--KVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNS-PG 449 ++ IT P +V D + D + + G +K + + Sbjct: 253 MRTRIPVITLVG-HKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMKVLTHHKRSV 311 Query: 450 SAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVM 509 A +L +V + I+ + L++ + + ++ + +SI+ + A GD Sbjct: 312 RATALHPKEFSVASACTDDIRSWGLAEGSLLTNFESEKTGIINTLSINQDDVLFAGGD-N 370 Query: 510 GKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEED--LVATGSLDTNIFI 567 G + YD +S S + + E+ ++ + TG D +I I Sbjct: 371 GVLSFYDYKSGHKYQS-----LATREMVGSLEGERSVLCSTFDKTGLRLITGEADKSIKI 425 Query: 568 YSVKRP 573 + Sbjct: 426 WKQDET 431 Score = 56.1 bits (133), Expect = 4e-08, Method: Composition-based stats. Identities = 36/169 (21%), Positives = 68/169 (40%), Gaps = 20/169 (11%) Query: 449 GSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYI---SISPSETYIAA 505 A+ N + T++V+ L+ + LKT L + ++S Y+ + Sbjct: 144 CVAIDPVDNEWFITGSNDTTMKVWDLA----TGKLKTTLAGHVMTVRDVAVSDRHPYLFS 199 Query: 506 GDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNI 565 + +DL+ ++ + H S + +S P DL+AT D+ I Sbjct: 200 VSEDKTVKCWDLEKNQI-IRDYYGHLSGVRTVSIHPTL----------DLIATAGRDSVI 248 Query: 566 FIYSVKRPMKIIKALNAHKDGVNNLLWE-TPSTLVSSGADACIKRWNVV 613 ++ + R + L HK +N + +VSS DA ++ W+VV Sbjct: 249 KLWDM-RTRIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVV 296 Score = 35.3 bits (79), Expect = 0.071, Method: Composition-based stats. Identities = 32/221 (14%), Positives = 61/221 (27%), Gaps = 52/221 (23%) Query: 24 LSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGS--SVVTTVKFSPIKGSQYL 81 +S PT + IA G+ + ++ D PV+ GH + V P + Sbjct: 230 VSIHPTLDLIA-TAGRDSVIKLWDMRTR--IPVITLVGHKGPINQVQCTPVDPQ-----V 281 Query: 82 CSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGP----------------------- 118 S V +W K + + +S P Sbjct: 282 VSSSTDATVRLWDVVAGKTMKVLTHHKRSVRATALHPKEFSVASACTDDIRSWGLAEGSL 341 Query: 119 -----------ISDISWDFEGRRLCVVGEGRDNFGVFIS------WDSGNSLGEVSGHSQ 161 I+ +S + + G +F + S + +G + G Sbjct: 342 LTNFESEKTGIINTLSINQDDVLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEGERS 401 Query: 162 RINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTH 202 + C +R +T D S+ ++ S+ Sbjct: 402 VL--CSTFDKTGLRLITGEADKSIKIWKQDETATKESEPGL 440 Score = 33.4 bits (74), Expect = 0.31, Method: Composition-based stats. Identities = 16/85 (18%), Positives = 32/85 (37%), Gaps = 11/85 (12%) Query: 529 FHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVN 588 H + ++ P ++ + TGS DT + ++ + K+ L H V Sbjct: 137 GHLGWVRCVAIDP---------VDNEWFITGSNDTTMKVWDLA-TGKLKTTLAGHVMTVR 186 Query: 589 NLLWETPST-LVSSGADACIKRWNV 612 ++ L S D +K W++ Sbjct: 187 DVAVSDRHPYLFSVSEDKTVKCWDL 211 >1VYH-C nrPDB Length = 410 Score = 148 bits (372), Expect = 1e-35, Method: Composition-based stats. Identities = 53/328 (16%), Positives = 104/328 (31%), Gaps = 57/328 (17%) Query: 156 VSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFS 215 +SGH + ++ +D ++ + F +RT V+D+ F Sbjct: 104 LSGHRSPVTRVIFHPVF-SVMVSASEDATIKVWDYETGDF---ERTLKGHTDSVQDISFD 159 Query: 216 PDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADAT 275 SG+ + + +D I +D + E ++ + V + + D T Sbjct: 160 -HSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSI---MPNGDHIVSASRDKT 215 Query: 276 IRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTI 335 I++W+V T CV+ +T + ++ I S S D T+ + + E + Sbjct: 216 IKMWEVQTGYCVKTFTGHR---EWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAEL 272 Query: 336 SGHNKGITALTVNP------------------------LISGSYDGRIMEWSSSSM---- 367 H + ++ P L+SGS D I W S+ Sbjct: 273 REHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLM 332 Query: 368 -HQDHSNLIVSLDN-SKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTN 425 H N + + S + S + D TL+V N L Sbjct: 333 TLVGHDNWVRGVLFHSGGKFILSCADDKTLRV--------------WDYKNKRCMKTLNA 378 Query: 426 DDDLL--ILQSFTGDIIKSVRLNSPGSA 451 + + + T + + ++ Sbjct: 379 HEHFVTSLDFHKTAPYVVTGSVDQTVKV 406 Score = 136 bits (342), Expect = 3e-32, Method: Composition-based stats. Identities = 53/336 (15%), Positives = 108/336 (32%), Gaps = 82/336 (24%) Query: 52 KVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSE 111 + P +GH S V T V F P+ + S E + VW + + + Sbjct: 97 RPPEKYALSGHRSPV-TRVIFHPVFS--VMVSASEDATIKVWDYE--------TGDFERT 145 Query: 112 FQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWD-SG-NSLGEVSGHSQRINACHLK 169 + + DIS+D G+ L WD G + + GH +++ + Sbjct: 146 LKGHTDSVQDISFDHSGKLLASCSADM----TIKLWDFQGFECIRTMHGHDHNVSSVSIM 201 Query: 170 QSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHK------------------------- 204 + ++ D ++ ++ + H + Sbjct: 202 PNGDH-IVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRV 260 Query: 205 --------------QGSFVRDVEFSPDS-------------------GEFVITVGSDRKI 231 V + ++P+S G F+++ D+ I Sbjct: 261 WVVATKECKAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTI 320 Query: 232 SCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWT 291 +D +G L + V+G +F + + D T+RVWD +C++ T Sbjct: 321 KMWDVSTGMCLMTLVGHDNWVRGVLFHSG---GKFILSCADDKTLRVWDYKNKRCMK--T 375 Query: 292 LDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELG 327 L+ + + T +++ S+D T+ +E Sbjct: 376 LNAHEHFVTSLDFHKTA-PYVVTGSVDQTVKVWECR 410 Score = 101 bits (252), Expect = 7e-22, Method: Composition-based stats. Identities = 58/338 (17%), Positives = 115/338 (34%), Gaps = 44/338 (13%) Query: 244 YIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVG 303 + + PV IF + + DATI+VWD T + TL Q + Sbjct: 103 ALSGHRSPVTRVIFHPVF---SVMVSASEDATIKVWDYETGD--FERTLKGHTDSVQDIS 157 Query: 304 VVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRI 359 +G + S S D T+ ++ E ++T+ GH+ ++++++ P ++S S D I Sbjct: 158 FDHSG-KLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTI 216 Query: 360 MEWSSSSM-----HQDHSNLIVSLD-NSKAQEYSSISWDDTLKVNGITKHEFGSQPKVAS 413 W + H + + N +S S D T++V Sbjct: 217 KMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRV--------------WV 262 Query: 414 ANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFK 473 A L ++ S+ + S + GS S L G+ + K Sbjct: 263 VATKECKAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLS-GSRDKTIK 321 Query: 474 LSDLEVSFDLKTPLRAK--PSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHT 531 + D+ L T + + +I + + ++D +++ H Sbjct: 322 MWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRC-MKTLNAHE 380 Query: 532 SKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYS 569 + ++ + V TGS+D + ++ Sbjct: 381 HFVTSLDFHKTAPY----------VVTGSVDQTVKVWE 408 Score = 79.6 bits (194), Expect = 3e-15, Method: Composition-based stats. Identities = 50/302 (16%), Positives = 101/302 (33%), Gaps = 60/302 (19%) Query: 333 KTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSM-----HQDHSNLIVSLDNSKA 383 +SGH +T + +P ++S S D I W + + H++ + + + Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161 Query: 384 Q-EYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLL--ILQSFTGDII 440 +S S D T+K+ + D + + GD I Sbjct: 162 GKLLASCSADMTIKL--------------WDFQGFECIRTMHGHDHNVSSVSIMPNGDHI 207 Query: 441 KSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSE 500 S + + Y V G+ V + +P+ Sbjct: 208 VSASRDKTIKMWEVQTGYC-VKTFTGHREWVRMV---------------RPNQ-----DG 246 Query: 501 TYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEED------ 554 T IA+ + ++ + ++E K + H + ISW P ++ E Sbjct: 247 TLIASCSNDQTVRVWVVATKECK-AELREHRHVVECISWAPESSYSSISEATGSETKKSG 305 Query: 555 ----LVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPST-LVSSGADACIKR 609 + +GS D I ++ V M ++ L H + V +L+ + ++S D ++ Sbjct: 306 KPGPFLLSGSRDKTIKMWDVSTGMCLMT-LVGHDNWVRGVLFHSGGKFILSCADDKTLRV 364 Query: 610 WN 611 W+ Sbjct: 365 WD 366 Score = 52.6 bits (124), Expect = 5e-07, Method: Composition-based stats. Identities = 37/236 (15%), Positives = 71/236 (30%), Gaps = 56/236 (23%) Query: 400 ITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSF--TGDIIKSVRLNSPGSAVSLSQN 457 + + KV F L D + SF +G ++ S + Q Sbjct: 123 MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDF-QG 181 Query: 458 YVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDL 517 + + G+ V S +SI P+ +I + I ++++ Sbjct: 182 FECIRTMHGHDHNV--------------------SSVSIMPNGDHIVSASRDKTIKMWEV 221 Query: 518 QSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKII 577 Q+ + H + + + L+A+ S D + ++ V + Sbjct: 222 QTGYC-VKTFTGHREWVRMV----------RPNQDGTLIASCSNDQTVRVW-VVATKECK 269 Query: 578 KALNAHKDGVNNLLWETPST---------------------LVSSGADACIKRWNV 612 L H+ V + W S+ L+S D IK W+V Sbjct: 270 AELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDV 325 >4LG8-A nrPDB Length = 354 Score = 144 bits (363), Expect = 9e-35, Method: Composition-based stats. Identities = 56/327 (17%), Positives = 112/327 (34%), Gaps = 50/327 (15%) Query: 202 HHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSW 261 H + ++ P ++T G+D+ + FD S + L ++ + V +F S Sbjct: 67 HSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQ 126 Query: 262 LDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTL 321 + DATIR+W V + CVQ + + + + ATG+ ++S S D Sbjct: 127 ---DLVFSASPDATIRIWSVPNASCVQ--VVRAHESAVTGLSLHATGD-YLLSSSDDQYW 180 Query: 322 NFYELGHDEVLKTISGHNKGI--TALTVNP----LISGSYDGRIMEWS-----SSSMHQD 370 F ++ VL ++ G T +P +G+ D +I W + + Sbjct: 181 AFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPG 240 Query: 371 HSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLL 430 HS I S+ S+ Y + + D S K+ L D++ Sbjct: 241 HSGPITSIAFSENGYYLATAAD-------------DSSVKLWDLRKLKNFKTLQLDNNFE 287 Query: 431 ILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAK 490 + + A+ + + + + + + S L Sbjct: 288 VKSLIFDQ-------SGTYLALGGTDVQIYICKQWTEILHFTEHSGLT------------ 328 Query: 491 PSYISISPSETYIAAGDVMGKILLYDL 517 + ++ +IA+ + + Y L Sbjct: 329 -TGVAFGHHAKFIASTGMDRSLKFYSL 354 Score = 98.8 bits (244), Expect = 5e-21, Method: Composition-based stats. Identities = 44/242 (18%), Positives = 89/242 (36%), Gaps = 20/242 (8%) Query: 163 INACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFV 222 I A L S + +T G D +VV + + A+ + H K+ V V F P S + V Sbjct: 74 ILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKK---VTSVVFHP-SQDLV 129 Query: 223 ITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVT 282 + D I + + ++ + + V G + + D D+ Sbjct: 130 FSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHAT---GDYLLSSSDDQYWAFSDIQ 186 Query: 283 TSKCVQKWTLDKQQLGNQQVGVVATGNGRII-SLSLDGTLNFYELGHDEVLKTISGHNKG 341 T + + K T + G +G I + ++D + ++L + GH+ Sbjct: 187 TGRVLTKVTDETS--GCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGP 244 Query: 342 ITALTVNP----LISGSYDGRIMEWSSSSMHQ------DHSNLIVSLDNSKAQEYSSISW 391 IT++ + L + + D + W + D++ + SL ++ Y ++ Sbjct: 245 ITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGG 304 Query: 392 DD 393 D Sbjct: 305 TD 306 Score = 44.9 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 25/175 (14%), Positives = 51/175 (29%), Gaps = 28/175 (16%) Query: 67 VTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDF 126 +T +F P +G ++ +W E + F +GPI+ I++ Sbjct: 203 LTCAQFHP--DGLIFGTGTMDSQIKIWDLK--------ERTNVANFPGHSGPITSIAFSE 252 Query: 127 EGRRLCVVGEGRDNFGVFISWD--SGNSLGEVSGHSQR-INACHLKQSRPMRSMTVGDDG 183 G L + WD + + + + + QS ++ D Sbjct: 253 NGYYLATAADD----SSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD-- 306 Query: 184 SVVFYQGPPFKFSASDRTHH--KQGSFVRDVEFSPDSGEFVITVGSDRKISCFDG 236 + H + V F +F+ + G DR + + Sbjct: 307 ------VQIYICKQWTEILHFTEHSGLTTGVAFG-HHAKFIASTGMDRSLKFYSL 354 Score = 43.8 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 27/192 (14%), Positives = 66/192 (34%), Gaps = 37/192 (19%) Query: 455 SQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILL 514 N + G + N + VF S ++ LK + K + + PS+ + + I + Sbjct: 83 DTNKILTGGADKNVV-VFDKSSEQILATLKGHTK-KVTSVVFHPSQDLVFSASPDATIRI 140 Query: 515 YDLQS---------REVKTSRWAFHTSKINAISWKPAEKGANEE---------------- 549 + + + E + + H + +S + A + Sbjct: 141 WSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSG 200 Query: 550 --------EIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPS-TLVS 600 + + TG++D+ I I+ +K + H + ++ + L + Sbjct: 201 CSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVA-NFPGHSGPITSIAFSENGYYLAT 259 Query: 601 SGADACIKRWNV 612 + D+ +K W++ Sbjct: 260 AADDSSVKLWDL 271 >3JB9-L nrPDB Length = 340 Score = 144 bits (363), Expect = 1e-34, Method: Composition-based stats. Identities = 58/316 (18%), Positives = 118/316 (37%), Gaps = 34/316 (10%) Query: 55 PVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQV 114 P +Q GH + V+ +F P Y SG ++++W D ++ V K Sbjct: 42 PNLQMFGHTAEVL-VARFDP--SGSYFASGGMDRQILLWNVFGDVKNYGVLNGCK----- 93 Query: 115 LAGPISDISWDFEGRRLCVVGEGRDNFGVFISWD--SGNSLGEVSGHSQRINACHLKQSR 172 G I+D+ W + R + +SWD SG + + GH+ +NA + + Sbjct: 94 --GAITDLQWSRDSRVVYCSSSD----THLMSWDAVSGQKIRKHKGHAGVVNALDVLKVG 147 Query: 173 PMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKIS 232 +V DD ++ + + + + V + G V G D I Sbjct: 148 SELLTSVSDDCTMKVWDSRSKDCIKTIE----EKYPLTAVAIA-QQGTQVFIGGIDGAIK 202 Query: 233 CFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVT----TSKCVQ 288 +D ++ ++ ++ + + D + D T+R++DV + +Q Sbjct: 203 IWDLRNNHCSHVLKGHKDIITSLAIS---KDGSSLLSNSMDNTVRIFDVKPFASAQRQLQ 259 Query: 289 KWTLDKQQLGNQQVGVVATGNGRII-SLSLDGTLNFYELGHDEVLKTISGHNKGITALTV 347 + + +GV + N R + + S D + + ++ + GH + + Sbjct: 260 IFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVWS-ATGDLRYVLPGHEGSVNHVDF 318 Query: 348 NP----LISGSYDGRI 359 +P ++S S D I Sbjct: 319 HPHQDIILSCSSDRTI 334 Score = 103 bits (256), Expect = 3e-22, Method: Composition-based stats. Identities = 44/266 (16%), Positives = 95/266 (35%), Gaps = 18/266 (6%) Query: 158 GHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPD 217 GH+ + S + + G D ++ + F + + + D+++S D Sbjct: 48 GHTAEVLVARFDPSGSYFA-SGGMDRQILLW--NVFGDVKNYGVLNGCKGAITDLQWSRD 104 Query: 218 SGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIR 277 V SD + +D SG+ ++ + V + + S+ +V D T++ Sbjct: 105 -SRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVN--ALDVLKVGSELLTSVSDDCTMK 161 Query: 278 VWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISG 337 VWD + C++ +A ++ +DG + ++L ++ + G Sbjct: 162 VWDSRSKDCIKTIEEKYPLTAVA----IAQQGTQVFIGGIDGAIKIWDLRNNHCSHVLKG 217 Query: 338 HNKGITALTV----NPLISGSYDGRIMEWS--SSSMHQDHSNLIVSLDNSKAQEYSSISW 391 H IT+L + + L+S S D + + + Q + + + ++W Sbjct: 218 HKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAW 277 Query: 392 DDTLKVNGITKHEFGSQPKVASANND 417 + G V SA D Sbjct: 278 SRNSRFVG--AGSSDKNVYVWSATGD 301 Score = 76.5 bits (186), Expect = 3e-14, Method: Composition-based stats. Identities = 53/331 (16%), Positives = 107/331 (32%), Gaps = 44/331 (13%) Query: 247 DDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVA 306 V F S FA+ G D I +W+V V+ + + G + Sbjct: 48 GHTAEVLVARFDPS---GSYFASGGMDRQILLWNVFGD--VKNYGVLNGCKGAIT-DLQW 101 Query: 307 TGNGRIISLSL-DGTLNFYELGHDEVLKTISGHNKGITALTV-----NPLISGSYDGRIM 360 + + R++ S D L ++ + ++ GH + AL V L S S D + Sbjct: 102 SRDSRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMK 161 Query: 361 EWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFT 420 W S S + I +++ ++Y + + + K+ N+ + Sbjct: 162 VWDSRSK-----DCIKTIE----EKYPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCS 212 Query: 421 AVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVS 480 VL D+ I S+ NS + V + + I + E + Sbjct: 213 HVLKGHKDI-ITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHN 271 Query: 481 FDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWK 540 ++ S + ++ AG + ++ H +N + + Sbjct: 272 LL----------GVAWSRNSRFVGAGSSDKNVYVWSATGDLRYV--LPGHEGSVNHVDFH 319 Query: 541 PAEKGANEEEIEEDLVATGSLDTNIFIYSVK 571 P +D++ + S D IF+ + Sbjct: 320 P----------HQDIILSCSSDRTIFLGELN 340 Score = 43.0 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 27/125 (21%), Positives = 44/125 (35%), Gaps = 13/125 (10%) Query: 489 AKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANE 548 A+ PS +Y A+G + +ILL+++ I + W + Sbjct: 51 AEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQWSRDSR---- 106 Query: 549 EEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPST--LVSSGADAC 606 +V S DT++ + KI K H VN L + L S D Sbjct: 107 ------VVYCSSSDTHLMSWDAVSGQKIRKH-KGHAGVVNALDVLKVGSELLTSVSDDCT 159 Query: 607 IKRWN 611 +K W+ Sbjct: 160 MKVWD 164 >3MKQ-A nrPDB Length = 814 Score = 141 bits (356), Expect = 6e-34, Method: Composition-based stats. Identities = 68/391 (17%), Positives = 133/391 (34%), Gaps = 37/391 (9%) Query: 62 HGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISD 121 + S V + F P + ++ + SG+V +W + E S++V P+ Sbjct: 11 NRSDRVKGIDFHPTEP--WVLTTLYSGRVEIWNYETQVEVRSIQVTET--------PVRA 60 Query: 122 ISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGD 181 + + V + ++++G + + H I + + ++P ++ D Sbjct: 61 GKFIARKNWIIVGSDDFRIR--VFNYNTGEKVVDFEAHPDYIRSIAVHPTKPY-VLSGSD 117 Query: 182 DGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEF 241 D +V + A ++T FV V F+P + DR + + Sbjct: 118 DLTVKLWNWE--NNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTP 175 Query: 242 LKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQ 301 + QE + D T D TI++WD T CV TL+ Sbjct: 176 NFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVA--TLEGHMSNVSF 233 Query: 302 VGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPL-----ISGSYD 356 T IIS S DGTL + +V KT++ + + +P I+ +D Sbjct: 234 AVFHPTL-PIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFD 292 Query: 357 GRIMEWS------SSSMHQDHSNLIVSLDNSKAQEYSS--------ISWDDTLKVNGITK 402 S + S+ + N+ A + + + D+ L + Sbjct: 293 NGFTVLSLGNDEPTLSLDPVGKLVWSGGKNAAASDIFTAVIRGNEEVEQDEPLSLQTKEL 352 Query: 403 HEFGSQPKVASANNDGFTAVLTNDDDLLILQ 433 P+ + + +G + D + +I Sbjct: 353 GSVDVFPQSLAHSPNGRFVTVVGDGEYVIYT 383 Score = 64.9 bits (156), Expect = 1e-10, Method: Composition-based stats. Identities = 51/345 (14%), Positives = 102/345 (29%), Gaps = 90/345 (26%) Query: 243 KYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQV 302 K + + V+G F + T + +W+ T V+ ++ + + Sbjct: 7 KTFSNRSDRVKGIDFHPTEP---WVLTTLYSGRVEIWNYET--QVEVRSIQVTETPVRAG 61 Query: 303 GVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGR 358 +A N II S D + + E + H I ++ V+P ++SGS D Sbjct: 62 KFIARKN-WIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLT 120 Query: 359 IMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDG 418 + W+ + ++++ PK S G Sbjct: 121 VKLWNWENNWALEQTF-----EGHEHFVMCVAFN----------------PKDPSTFASG 159 Query: 419 FTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLE 478 T++V+ L Sbjct: 160 CL---------------------------------------------DRTVKVWSLGQST 174 Query: 479 VSFDLKTPLRAKPSYISISP--SETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINA 536 +F L T +Y+ P + Y+ I ++D Q++ + H S ++ Sbjct: 175 PNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSC-VATLEGHMSNVSF 233 Query: 537 ISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALN 581 + P ++ +GS D + I++ K+ K LN Sbjct: 234 AVFHPTLP----------IIISGSEDGTLKIWN-SSTYKVEKTLN 267 Score = 53.8 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 35/206 (16%), Positives = 82/206 (39%), Gaps = 23/206 (11%) Query: 415 NNDGFTAVLTNDDDLLILQSFTGDIIKSVRL-NSPGSA--VSLSQNYVAVGLEEGNTIQV 471 + + + I T ++S+++ +P A +N++ VG ++ I+V Sbjct: 23 PTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKFIARKNWIIVGSDDF-RIRV 81 Query: 472 FKLSDLEVSFDLKTPLRAKPSYI---SISPSETYIAAGDVMGKILLYDLQSREVKTSRWA 528 F + E D A P YI ++ P++ Y+ +G + L++ ++ + Sbjct: 82 FNYNTGEKVVDF----EAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALEQTFE 137 Query: 529 FHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVN 588 H + +++ P + A+G LD + ++S+ + + GVN Sbjct: 138 GHEHFVMCVAFNPK---------DPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVN 188 Query: 589 NLLW---ETPSTLVSSGADACIKRWN 611 + + ++++ D IK W+ Sbjct: 189 YVDYYPLPDKPYMITASDDLTIKIWD 214 Score = 38.4 bits (87), Expect = 0.010, Method: Composition-based stats. Identities = 50/341 (14%), Positives = 100/341 (29%), Gaps = 70/341 (20%) Query: 43 VRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESN 102 V+ G S T V V + P+ Y+ + + + +W + Sbjct: 165 VKVWSLGQSTPN--FTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQT----- 217 Query: 103 SVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDS------------- 149 KS L G +S++S+ L ++ G ++ G W+S Sbjct: 218 ------KSCVATLEGHMSNVSFAVFHPTLPIIISGSED-GTLKIWNSSTYKVEKTLNVGL 270 Query: 150 -----------GNSLGEVSGHSQRINACHLKQSRPMRSM--------------TVGDDGS 184 G SG L P S+ D + Sbjct: 271 ERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSLDPVGKLVWSGGKNAAASDIFT 330 Query: 185 VVFYQGPPFKF--SASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFL 242 V + S +T V + +TV D + + L Sbjct: 331 AVIRGNEEVEQDEPLSLQTKELGSVDVFPQSLAHSPNGRFVTVVGDGEYVIY-----TAL 385 Query: 243 KYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQV 302 + Q ++ DS +A + D T ++ K V W++ ++ Sbjct: 386 AWRNKAFGKCQDFVWG---PDSNSYALI--DETGQIKYYKNFKEVTSWSVPMHSAIDRLF 440 Query: 303 GVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGIT 343 +G ++ + DG + F++ + +++ I + K + Sbjct: 441 ------SGALLGVKSDGFVYFFDWDNGTLVRRIDVNAKDVI 475 >4BTS-AR nrPDB Length = 343 Score = 138 bits (347), Expect = 7e-33, Method: Composition-based stats. Identities = 52/336 (15%), Positives = 124/336 (36%), Gaps = 46/336 (13%) Query: 153 LGEVSGHSQRINA--CHLKQSRPMRS---MTVGDDGSVVFYQG----PPFKFSASDRTHH 203 G + GHS + + Q S ++ D +V+ ++ F + Sbjct: 14 RGILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALT 73 Query: 204 KQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLD 263 FV D+ S ++ F I+ D+ + +D ++G K Q V F+ D Sbjct: 74 GHNHFVSDLALSQENC-FAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFS---PD 129 Query: 264 SQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATG-----------NGRI 312 +++ + GA+ I++W++ +C + + +K+ + V + Sbjct: 130 NRQILSAGAEREIKLWNI-LGEC-KFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYF 187 Query: 313 ISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSS-M 367 S+ DG L + + ++ T H + L+++P + +G D +++ W + Sbjct: 188 ASVGWDGRLKVWN-TNFQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKLLIWDILNLT 246 Query: 368 HQ----DHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHE------FGSQPKVASANND 417 + D + I + + ++ ++ D +K+ + ++P + Sbjct: 247 YPQREFDAGSTINQIAFNPKLQWVAVGTDQGVKIFNLMTQSKAPVCTIEAEPITKAEGQK 306 Query: 418 G----FTAVLTNDDDLLILQSFTGDIIKSVRLNSPG 449 G T++ N + FT +I++ + Sbjct: 307 GKNPQCTSLAWNALGKKLFAGFTDGVIRTFSFETSA 342 Score = 106 bits (263), Expect = 3e-23, Method: Composition-based stats. Identities = 40/310 (12%), Positives = 92/310 (29%), Gaps = 37/310 (11%) Query: 58 QFTGHGSSVVTTVKFSPIKGSQ---YLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQV 114 GH V + V K ++ L SG V++W ++E N Sbjct: 16 ILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLY-EEEQNGYFGIPHKALTG 74 Query: 115 LAGPISDISWDFEGRRLCVVGEGRDNFGVFISWD--SGNSLGEVSGHSQRINACHLKQSR 172 +SD++ E + WD +G + GH + + Sbjct: 75 HNHFVSDLALSQENCFAISSSWDK----TLRLWDLRTGTTYKRFVGHQSEVYSVAFSP-D 129 Query: 173 PMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSP---------DSGEFVI 223 + ++ G + + + + S +V V +SP + Sbjct: 130 NRQILSAGAEREIKLW-NILGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFA 188 Query: 224 TVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTT 283 +VG D ++ ++ + + + V + + + AT G D + +WD+ Sbjct: 189 SVGWDGRLKVWNTNF-QIRYTFKAHESNVNHLSIS---PNGKYIATGGKDKKLLIWDILN 244 Query: 284 SKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGIT 343 + + G+ + + +++ D + + L + Sbjct: 245 L----TYPQREFDAGSTINQIAFNPKLQWVAVGTDQGVKIFNLMTQS--------KAPVC 292 Query: 344 ALTVNPLISG 353 + P+ Sbjct: 293 TIEAEPITKA 302 Score = 72.6 bits (176), Expect = 4e-13, Method: Composition-based stats. Identities = 57/349 (16%), Positives = 124/349 (35%), Gaps = 49/349 (14%) Query: 285 KCVQKWTLDKQQLGNQQVGVVAT-----GNGRIISLSLDGTLNFYELGHDEV-------L 332 + V++ L+ + + + +IS S D T+ ++L +E Sbjct: 10 QVVKRGILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPH 69 Query: 333 KTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSM-----HQDHSNLIVSLDNSK- 382 K ++GHN ++ L ++ IS S+D + W + H + + S+ S Sbjct: 70 KALTGHNHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSPD 129 Query: 383 AQEYSSISWDDTLKV-NGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIK 441 ++ S + +K+ N + + +F S K N D + ++ Sbjct: 130 NRQILSAGAEREIKLWNILGECKFSSAEK-------------ENHSDWV-------SCVR 169 Query: 442 SVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSET 501 + + V Y A +G + +F + +++SISP+ Sbjct: 170 YSPIMKSANKVQPFAPYFASVGWDGRLKVWNTNFQIRYTFKAH---ESNVNHLSISPNGK 226 Query: 502 YIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSL 561 YIA G K+L++D+ + + S IN I++ P + + + Sbjct: 227 YIATGGKDKKLLIWDILNLTYPQREFDA-GSTINQIAFNPKLQWVAVGTDQGVKIFNLMT 285 Query: 562 DTNIFIYSVK-RPMKIIKALNAHKDGVNNLLWETPSTLVSSG-ADACIK 608 + + +++ P+ + +L W + +G D I+ Sbjct: 286 QSKAPVCTIEAEPITKAEGQKGKNPQCTSLAWNALGKKLFAGFTDGVIR 334 Score = 61.1 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 45/291 (15%), Positives = 99/291 (34%), Gaps = 76/291 (26%) Query: 335 ISGHNKGITALTV---------NP-LISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQ 384 + GH+ +T++ +P LISGS D +M W ++++ N + + Sbjct: 17 LEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIW---KLYEEEQNGYFGIPHKALT 73 Query: 385 EYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVR 444 ++ D L + F + D L + TG Sbjct: 74 GHNHFVSDLALS------------------QENCFAISSSWDKTLRLWDLRTG------- 108 Query: 445 LNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIA 504 + + +V G+ +V+ ++ SP I Sbjct: 109 --------TTYKRFV------GHQSEVY--------------------SVAFSPDNRQIL 134 Query: 505 AGDVMGKILLYDLQSREVKTSRWA-FHTSKINAISWKPAEKGANEEEIEEDLVATGSLDT 563 + +I L+++ +S H+ ++ + + P K AN+ + A+ D Sbjct: 135 SAGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDG 194 Query: 564 NIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSGA-DACIKRWNVV 613 + +++ +I AH+ VN+L +++G D + W+++ Sbjct: 195 RLKVWNTN--FQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKLLIWDIL 243 Score = 43.8 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 27/171 (15%), Positives = 62/171 (36%), Gaps = 34/171 (19%) Query: 453 SLSQNYVAVGLEEGNTIQV-FKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGK 511 SL V G+ EG++ V ++ + +P+ + +G Sbjct: 6 SLDIQVVKRGILEGHSDWVTSIVAGFSQKENEDSPV---------------LISGSRDKT 50 Query: 512 ILLYDLQSRE------VKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNI 565 ++++ L E + H ++ ++ E + S D + Sbjct: 51 VMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLALS----------QENCFAISSSWDKTL 100 Query: 566 FIYSVKRPMKIIKALNAHKDGVNNLLWETPST-LVSSGADACIKRWNVVLE 615 ++ + R K H+ V ++ + + ++S+GA+ IK WN++ E Sbjct: 101 RLWDL-RTGTTYKRFVGHQSEVYSVAFSPDNRQILSAGAEREIKLWNILGE 150 >2YNP-A nrPDB Length = 604 Score = 138 bits (346), Expect = 8e-33, Method: Composition-based stats. Identities = 68/391 (17%), Positives = 133/391 (34%), Gaps = 37/391 (9%) Query: 62 HGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISD 121 + S V + F P + ++ + SG+V +W + E S++V P+ Sbjct: 11 NRSDRVKGIDFHPTEP--WVLTTLYSGRVELWNYETQVEVRSIQVTET--------PVRA 60 Query: 122 ISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGD 181 + + V + ++++G + + H I + + ++P ++ D Sbjct: 61 GKFIARKNWIIVGSDDFRIR--VFNYNTGEKVVDFEAHPDYIRSIAVHPTKPY-VLSGSD 117 Query: 182 DGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEF 241 D +V + A ++T FV V F+P + DR + + Sbjct: 118 DLTVKLWNWE--NNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTP 175 Query: 242 LKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQ 301 + QE + D T D TI++WD T CV TL+ Sbjct: 176 NFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVA--TLEGHMSNVSF 233 Query: 302 VGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPL-----ISGSYD 356 T IIS S DGTL + +V KT++ + + +P I+ +D Sbjct: 234 AVFHPTL-PIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFD 292 Query: 357 GRIMEWS------SSSMHQDHSNLIVSLDNSKAQEYSS--------ISWDDTLKVNGITK 402 S + S+ + N+ A + + + D+ L + Sbjct: 293 NGFTVLSLGNDEPTLSLDPVGKLVWSGGKNAAASDIFTAVIRGNEEVEQDEPLSLQTKEL 352 Query: 403 HEFGSQPKVASANNDGFTAVLTNDDDLLILQ 433 P+ + + +G + D + +I Sbjct: 353 GSVDVFPQSLAHSPNGRFVTVVGDGEYVIYT 383 Score = 62.2 bits (149), Expect = 6e-10, Method: Composition-based stats. Identities = 51/345 (14%), Positives = 102/345 (29%), Gaps = 90/345 (26%) Query: 243 KYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQV 302 K + + V+G F + T + +W+ T V+ ++ + + Sbjct: 7 KTFSNRSDRVKGIDFHPTEP---WVLTTLYSGRVELWNYET--QVEVRSIQVTETPVRAG 61 Query: 303 GVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGR 358 +A N II S D + + E + H I ++ V+P ++SGS D Sbjct: 62 KFIARKN-WIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLT 120 Query: 359 IMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDG 418 + W+ + ++++ PK S G Sbjct: 121 VKLWNWENNWALEQTF-----EGHEHFVMCVAFN----------------PKDPSTFASG 159 Query: 419 FTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLE 478 T++V+ L Sbjct: 160 CL---------------------------------------------DRTVKVWSLGQST 174 Query: 479 VSFDLKTPLRAKPSYISISP--SETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINA 536 +F L T +Y+ P + Y+ I ++D Q++ + H S ++ Sbjct: 175 PNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSC-VATLEGHMSNVSF 233 Query: 537 ISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALN 581 + P ++ +GS D + I++ K+ K LN Sbjct: 234 AVFHPTLP----------IIISGSEDGTLKIWN-SSTYKVEKTLN 267 Score = 51.8 bits (122), Expect = 7e-07, Method: Composition-based stats. Identities = 27/158 (17%), Positives = 62/158 (39%), Gaps = 19/158 (12%) Query: 460 AVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYI---SISPSETYIAAGDVMGKILLYD 516 + + I+VF + E D A P YI ++ P++ Y+ +G + L++ Sbjct: 70 IIVGSDDFRIRVFNYNTGEKVVDF----EAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWN 125 Query: 517 LQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKI 576 ++ + H + +++ P + A+G LD + ++S+ + Sbjct: 126 WENNWALEQTFEGHEHFVMCVAFNPK---------DPSTFASGCLDRTVKVWSLGQSTPN 176 Query: 577 IKALNAHKDGVNNLLW---ETPSTLVSSGADACIKRWN 611 + GVN + + ++++ D IK W+ Sbjct: 177 FTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWD 214 Score = 36.4 bits (82), Expect = 0.033, Method: Composition-based stats. Identities = 50/341 (14%), Positives = 100/341 (29%), Gaps = 70/341 (20%) Query: 43 VRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESN 102 V+ G S T V V + P+ Y+ + + + +W + Sbjct: 165 VKVWSLGQSTPN--FTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQT----- 217 Query: 103 SVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDS------------- 149 KS L G +S++S+ L ++ G ++ G W+S Sbjct: 218 ------KSCVATLEGHMSNVSFAVFHPTLPIIISGSED-GTLKIWNSSTYKVEKTLNVGL 270 Query: 150 -----------GNSLGEVSGHSQRINACHLKQSRPMRSM--------------TVGDDGS 184 G SG L P S+ D + Sbjct: 271 ERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSLDPVGKLVWSGGKNAAASDIFT 330 Query: 185 VVFYQGPPFKF--SASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFL 242 V + S +T V + +TV D + + L Sbjct: 331 AVIRGNEEVEQDEPLSLQTKELGSVDVFPQSLAHSPNGRFVTVVGDGEYVIY-----TAL 385 Query: 243 KYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQV 302 + Q ++ DS +A + D T ++ K V W++ ++ Sbjct: 386 AWRNKAFGKCQDFVWG---PDSNSYALI--DETGQIKYYKNFKEVTSWSVPMHSAIDRLF 440 Query: 303 GVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGIT 343 +G ++ + DG + F++ + +++ I + K + Sbjct: 441 ------SGALLGVKSDGFVYFFDWDNGTLVRRIDVNAKDVI 475 >5K1B-B nrPDB Length = 677 Score = 137 bits (344), Expect = 2e-32, Method: Composition-based stats. Identities = 51/250 (20%), Positives = 94/250 (37%), Gaps = 23/250 (9%) Query: 119 ISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNS-----LGEVSGHSQRINACHLKQSRP 173 ++ + D RL G + W + + H+ +N L + Sbjct: 33 VNALQLDPALNRLFTAGRD----SIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGK 88 Query: 174 MRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISC 233 + D +V + ++ RTH +V+ + ++ D E V + G DR+I Sbjct: 89 TLI-SASSDTTVKVWNAHKGFCMSTLRTHK---DYVKALAYAKDK-ELVASAGLDRQIFL 143 Query: 234 FDGKSGEFLKYIEDD--QEPVQGGIFALSWLDSQKFAT----VGADATIRVWDVTTSKCV 287 +D + L + + G ++ L + T + +RVWD T C Sbjct: 144 WDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRT--CA 201 Query: 288 QKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTV 347 + L K N + ++ + +S S DGT+ + LG + T H++G+ AL V Sbjct: 202 KLMKL-KGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQV 260 Query: 348 NPLISGSYDG 357 N + Y G Sbjct: 261 NDAFTHVYSG 270 Score = 85.7 bits (210), Expect = 5e-17, Method: Composition-based stats. Identities = 57/377 (15%), Positives = 113/377 (29%), Gaps = 85/377 (22%) Query: 18 RNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKG 77 RN L DP N + + G+ + +R K P + H + V + Sbjct: 30 RNGVNALQLDPALNRL-FTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVL--CCN 86 Query: 78 SQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEG 137 + L S V VW N+ + S + + +++ + + G Sbjct: 87 GKTLISASSDTTVKVW--------NAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLD 138 Query: 138 RDNF-----------------------------------------------GVFISWDSG 150 R F V WD Sbjct: 139 RQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPR 198 Query: 151 NS--LGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSF 208 L ++ GH+ + A L + + ++ DG++ + + A+ R H Sbjct: 199 TCAKLMKLKGHTDNVKALLLNRDG-TQCLSGSSDGTIRLWSLGQQRCIATYRVH---DEG 254 Query: 209 VRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFA 268 V ++ + D+ V + G DRKI C D ++ + I +++ PV S Sbjct: 255 VWALQVN-DAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDRSADPPPAIW 313 Query: 269 TVGADATIRVWDVT-------------------TSKCVQKWTLDKQQLGNQQVGVVATGN 309 +T+ W + T C Q + K Q ++ Sbjct: 314 VATTKSTVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGGASIIQCHIL-NDK 372 Query: 310 GRIISLSLDGTLNFYEL 326 I++ + + ++++ Sbjct: 373 RHILTKDTNNNVAYWDV 389 Score = 61.9 bits (148), Expect = 8e-10, Method: Composition-based stats. Identities = 39/267 (14%), Positives = 93/267 (34%), Gaps = 33/267 (12%) Query: 281 VTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEV---LKTISG 337 V S ++ + G + + N R+ + D + + + + + ++ Sbjct: 15 VQVSYVIRDEVEKYNRNGVNALQLDPALN-RLFTAGRDSIIRIWSVNQHKQDPYIASMEH 73 Query: 338 HNKGITALTVN----PLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDD 393 H + + + LIS S D + W++ H +S + ++++ Sbjct: 74 HTDWVNDIVLCCNGKTLISASSDTTVKVWNA------HKGFCMSTLRTHKDYVKALAYAK 127 Query: 394 TLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVS 453 ++ + Q + N LT ++ + S +G+ S S Sbjct: 128 DKEL--VASAGLDRQIFLWDVNT---LTALTASNNTVTTSSLSGN---------KDSIYS 173 Query: 454 LSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYIS---ISPSETYIAAGDVMG 510 L+ N + + G+T +V ++ D L L+ + ++ T +G G Sbjct: 174 LAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMK-LKGHTDNVKALLLNRDGTQCLSGSSDG 232 Query: 511 KILLYDLQSREVKTSRWAFHTSKINAI 537 I L+ L ++ + + H + A+ Sbjct: 233 TIRLWSL-GQQRCIATYRVHDEGVWAL 258 Score = 53.4 bits (126), Expect = 3e-07, Method: Composition-based stats. Identities = 36/222 (16%), Positives = 82/222 (36%), Gaps = 30/222 (13%) Query: 397 VNGITKHEFGSQPKVASANN---DGFTAVLTNDDDLL--ILQSFTGDIIKSVRLNSPGSA 451 +N + S ++ S N D + A + + D + I+ G + S ++ Sbjct: 42 LNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKV 101 Query: 452 VSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGK 511 + + + L + V L + + + +A+ + + Sbjct: 102 WNAHKGFCMSTLRT-HKDYVKAL--------------------AYAKDKELVASAGLDRQ 140 Query: 512 ILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVK 571 I L+D+ + T+ +T +++S + ++ +GS + + ++ + Sbjct: 141 IFLWDVNTLTALTAS--NNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPR 198 Query: 572 RPMKIIKALNAHKDGVNNLLWETPSTLVSSG-ADACIKRWNV 612 K++K L H D V LL T SG +D I+ W++ Sbjct: 199 TCAKLMK-LKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSL 239 >3JB9-S nrPDB Length = 488 Score = 136 bits (341), Expect = 3e-32, Method: Composition-based stats. Identities = 64/261 (24%), Positives = 110/261 (42%), Gaps = 40/261 (15%) Query: 215 SPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADA 274 SP++ FV+ + D ++ C D +S LK E G A WL S K A ADA Sbjct: 218 SPENSSFVLCLHKD-ELLCLDIQSNSTLKIFE-------GSALACCWLTSSKIAVATADA 269 Query: 275 TIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKT 334 I +++ S G Q VG + S+ +D +NF + H Sbjct: 270 -ISIFEFPVSSS-----------GLQSVGEPTS------SIPIDEKVNFLQ-AHPSGEYL 310 Query: 335 ISGHNKGITALTVNPLISGSYDGRIMEW-SSSSMHQDHSNLIVSLDNSKAQEYSSISWDD 393 ++ N+ + L S Y+ + + +S ++H D + + L+N + + + + Sbjct: 311 LAASNEKCYIFS---LKSQVYNITVAQHITSLAVHPDGNLFVAGLENGELRFF------E 361 Query: 394 TLKVNGITKHEFGSQP-KVASANNDGF-TAVLTNDD-DLLILQSFTGDIIKSVRLNSPGS 450 T N +TK S P K +G+ V TNDD D+ I ++++ + L + + Sbjct: 362 TSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKSELVQKIPLQTKVA 421 Query: 451 AVSLSQNYVAVGLEEGNTIQV 471 AVSL + +G T+ V Sbjct: 422 AVSLDITSQLLVSSDGETLYV 442 Score = 37.2 bits (84), Expect = 0.019, Method: Composition-based stats. Identities = 21/119 (17%), Positives = 45/119 (37%), Gaps = 9/119 (7%) Query: 160 SQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSG 219 +Q I + + + ++G + F++ H S V+ ++F + Sbjct: 333 AQHITSLAVHPDGN-LFVAGLENGELRFFETSSGNELTKFGPH---SSPVKTLQFGENGY 388 Query: 220 EFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRV 278 V+T D I +D + E ++ I P+Q + A+S + + T+ V Sbjct: 389 WLVVTTNDDSDIFIWDLRKSELVQKI-----PLQTKVAAVSLDITSQLLVSSDGETLYV 442 Score = 31.8 bits (70), Expect = 0.95, Method: Composition-based stats. Identities = 20/137 (14%), Positives = 41/137 (29%), Gaps = 5/137 (3%) Query: 114 VLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRP 173 +A I+ ++ +G E + F SGN L + HS + ++ Sbjct: 331 TVAQHITSLAVHPDGNLFVAGLENGELR--FFETSSGNELTKFGPHSSPVKTLQFGENGY 388 Query: 174 MRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVE---FSPDSGEFVITVGSDRK 230 +T DD + + + K + D+ GE + + Sbjct: 389 WLVVTTNDDSDIFIWDLRKSELVQKIPLQTKVAAVSLDITSQLLVSSDGETLYVHIYVKS 448 Query: 231 ISCFDGKSGEFLKYIED 247 + S + I + Sbjct: 449 SKSWRCMSQTHVSSISN 465 >5NZU-C nrPDB Length = 905 Score = 135 bits (339), Expect = 5e-32, Method: Composition-based stats. Identities = 42/233 (18%), Positives = 89/233 (38%), Gaps = 17/233 (7%) Query: 142 GVFISW--DSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASD 199 G W ++ + + A + +T DD + + + Sbjct: 37 GSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNW-VVTGADDMQIRVFN---YNTLERV 92 Query: 200 RTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSG-EFLKYIEDDQEPVQGGIFA 258 ++R + P + F++T D I +D + E V + Sbjct: 93 HMFEAHSDYIRCIAVHP-TQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVIN 151 Query: 259 LSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGN-GRIISLSL 317 D+ +FA+ D TI+VW + +TL+ + G + + G+ +IS + Sbjct: 152 P--KDNNQFASASLDRTIKVWQL--GSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGAD 207 Query: 318 DGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSS 366 D + ++ + ++T+ GH + ++ + +P +I+GS DG + W SS+ Sbjct: 208 DRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSST 260 Score = 103 bits (257), Expect = 2e-22, Method: Composition-based stats. Identities = 63/448 (14%), Positives = 146/448 (32%), Gaps = 64/448 (14%) Query: 78 SQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEG 137 ++ +G + ++ V+ + + + F+ + I I+ + + Sbjct: 69 KNWVVTGADDMQIRVFNYNTLERVH--------MFEAHSDYIRCIAVHPTQPFILTSSDD 120 Query: 138 RDNFGVFISWD---SGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFK 194 + WD + GH+ + + + + D ++ +Q Sbjct: 121 M----LIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGS-- 174 Query: 195 FSASDRTHHKQGSFVRDVE-FSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQ 253 S+ + T V ++ +S ++I+ DR + +D ++ ++ +E + V Sbjct: 175 -SSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVS 233 Query: 254 GGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRII 313 F T D T+R+W +T + + TL+ V + N + Sbjct: 234 CASFHPELP---IIITGSEDGTVRIWHSSTYR--LESTLNYGMERVWCVASLRGSNN--V 286 Query: 314 SLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPLISGSYDGRIMEWSSSSMHQDHSN 373 +L D ++ + P +S +G+I W+ S Q + Sbjct: 287 ALGYDE---------GSIIVKLG---------REEPAMSMDANGKI-IWAKHSEVQQANL 327 Query: 374 LIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQ 433 + K E ++ D P+ N +G V+ D + +I Sbjct: 328 KAMGDTEIKDGERLPLAVKD--------MGSCEIYPQTIQHNPNGRFVVVCGDGEYIIY- 378 Query: 434 SFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSY 493 T +++ S + E + +++FK + SF KP + Sbjct: 379 --TAMALRNKSFGSAQEFAWAHDSSEYAIRESNSIVKIFKNFKEKKSF--------KPDF 428 Query: 494 ISISPSETYIAAGDVMGKILLYDLQSRE 521 + S ++ + + YD ++ E Sbjct: 429 GAESIYGGFLLGVRSVNGLAFYDWENTE 456 Score = 55.3 bits (131), Expect = 8e-08, Method: Composition-based stats. Identities = 36/189 (19%), Positives = 72/189 (38%), Gaps = 18/189 (9%) Query: 429 LLILQSFTGDIIKSVR---LNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKT 485 + + T ++K+ L + +N+V G ++ I+VF + LE + Sbjct: 39 VCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADD-MQIRVFNYNTLE-RVHMFE 96 Query: 486 PLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKG 545 I++ P++ +I I L+D + + + HT + I P Sbjct: 97 AHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPK--- 153 Query: 546 ANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPST---LVSSG 602 + + A+ SLD I ++ + L H+ GVN + + + L+S Sbjct: 154 ------DNNQFASASLDRTIKVWQLGSSSP-NFTLEGHEKGVNCIDYYSGGDKPYLISGA 206 Query: 603 ADACIKRWN 611 D +K W+ Sbjct: 207 DDRLVKIWD 215 Score = 38.4 bits (87), Expect = 0.009, Method: Composition-based stats. Identities = 24/150 (16%), Positives = 45/150 (30%), Gaps = 18/150 (12%) Query: 43 VRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESN 102 ++ G S GH V + + YL SG + V +W + Sbjct: 167 IKVWQLGSSSPN--FTLEGHEKGVNC-IDYYSGGDKPYLISGADDRLVKIWDYQ------ 217 Query: 103 SVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSL--GEVSGHS 160 + A +S S+ E + E G W S ++ Sbjct: 218 --NKTCVQTLEGHAQNVSCASFHPELPIIITGSED----GTVRIWHSSTYRLESTLNYGM 271 Query: 161 QRINACHLKQSRPMRSMTVGDDGSVVFYQG 190 +R+ + ++ D+GS++ G Sbjct: 272 ERVWCVASLRGSNNVAL-GYDEGSIIVKLG 300 >5GAN-H nrPDB Length = 465 Score = 130 bits (326), Expect = 2e-30, Method: Composition-based stats. Identities = 57/290 (19%), Positives = 106/290 (36%), Gaps = 18/290 (6%) Query: 84 GDESGKVIVWGWTFDKE--SNSVEVNVKSEFQVLAGPISDISW--DFEGRRLCVVGEGRD 139 + V W D + ++ + + G I I W D + + +G Sbjct: 184 STDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDGLI 243 Query: 140 NFGVFISWDSG-NSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSAS 198 + + + G LG++ GH +RI+ S + D + + + Sbjct: 244 KNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKF-IGSASHDMTWRLWDASTHQELLL 302 Query: 199 DRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFA 258 H K V + F D G V + G D +D +SG + + +P+ ++ Sbjct: 303 QEGHDKG---VFSLSFQCD-GSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWS 358 Query: 259 LSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGR-IISLSL 317 + + AT G D I VWD+ Q + + QV G+ ++S Sbjct: 359 ---PNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGY 415 Query: 318 DGTLNFYELGHDEVLKTISGHNKGITALTV----NPLISGSYDGRIMEWS 363 D +N Y + +++GH I +L + + L+SG +D I W+ Sbjct: 416 DNLINVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465 Score = 99.2 bits (245), Expect = 4e-21, Method: Composition-based stats. Identities = 45/253 (17%), Positives = 92/253 (36%), Gaps = 21/253 (8%) Query: 160 SQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSG 219 ++ I+A L + M T G + + + + +++ PDS Sbjct: 175 TKPISAVSLS-TDDMVVATGSWAGDLQVLNSQTLQPLT--QKLDSHVGKIGAIDWHPDSN 231 Query: 220 EFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQK-FATVGADATIRV 278 +I+ D I F + E + D + I + + S K + D T R+ Sbjct: 232 NQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRL 291 Query: 279 WDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGH 338 WD +T + + + G + + S +D +++ + T++GH Sbjct: 292 WDASTHQEL--LLQEGHDKGVFSLSFQ-CDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGH 348 Query: 339 NKGITALTVNP----LISGSYDGRIMEWSSSSMHQD-------HSNLIVSLDNSK---AQ 384 +K I + +P + +G DG I W + H N++ + SK + Sbjct: 349 SKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDGGK 408 Query: 385 EYSSISWDDTLKV 397 + S +D+ + V Sbjct: 409 KLVSCGYDNLINV 421 Score = 85.0 bits (208), Expect = 8e-17, Method: Composition-based stats. Identities = 52/326 (15%), Positives = 104/326 (31%), Gaps = 52/326 (15%) Query: 207 SFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQK 266 + V S D V T + + ++ + L D G I ++Q Sbjct: 176 KPISAVSLSTDD-MVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQM 234 Query: 267 FATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRII-SLSLDGTLNFYE 325 + D I+ + + + + D + V +G+ I S S D T ++ Sbjct: 235 I-SCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWD 293 Query: 326 LGHDEVLKTISGHNKGITALTV----NPLISGSYDGRIMEWSSSSM-----HQDHSNLIV 376 + L GH+KG+ +L+ + + SG D M W S HS I Sbjct: 294 ASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIY 353 Query: 377 SLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASAN--NDGFTAVLTNDDDLLILQS 434 ++ S + D + V ++G + +++ Sbjct: 354 TVAWSPNGYQVATGGGDGII-------------NVWDIRKRDEGQLNQILAHRNIVTQVR 400 Query: 435 FT----GDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAK 490 F+ G + S ++ + S ++ +G G+T K Sbjct: 401 FSKEDGGKKLVSCGYDNLINVYSSD-TWLKMGSLAGHT--------------------DK 439 Query: 491 PSYISISPSETYIAAGDVMGKILLYD 516 + IS + ++ +G I L++ Sbjct: 440 IISLDISNNSHFLVSGGWDRSIKLWN 465 Score = 73.4 bits (178), Expect = 3e-13, Method: Composition-based stats. Identities = 65/375 (17%), Positives = 124/375 (33%), Gaps = 96/375 (25%) Query: 249 QEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATG 308 +P+ + D AT ++V + T + + LD + Sbjct: 175 TKPISAVSLS---TDDMVVATGSWAGDLQVLNSQTLQPL-TQKLDSHVGKIGAIDWHPDS 230 Query: 309 NGRIISLSLDGTLNFYELGHD----EVLKTISGHNKGITALTVNP----LISGSYDGRIM 360 N ++IS + DG + ++ ++ +L + GH + I+ + +P + S S+D M Sbjct: 231 NNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHD---M 287 Query: 361 EWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFT 420 W WD + + + S DG Sbjct: 288 TWRL--------------------------WDASTHQELLLQEGHDKGVFSLSFQCDGSL 321 Query: 421 AVLTNDDDL-LILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEV 479 D L ++ +G +V L+ Sbjct: 322 VCSGGMDSLSMLWDIRSGS-------------------------------KVMTLAG--- 347 Query: 480 SFDLKTPLRAKPSY-ISISPSETYIAAGDVMGKILLYDLQSRE-VKTSRWAFHTSKINAI 537 +KP Y ++ SP+ +A G G I ++D++ R+ + ++ H + + + Sbjct: 348 --------HSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQV 399 Query: 538 SWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPST 597 + + G + + D I +YS +K+ +L H D + +L S Sbjct: 400 RFSKEDGGKK--------LVSCGYDNLINVYSSDTWLKM-GSLAGHTDKIISLDISNNSH 450 Query: 598 -LVSSGADACIKRWN 611 LVS G D IK WN Sbjct: 451 FLVSGGWDRSIKLWN 465 Score = 64.2 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 36/211 (17%), Positives = 68/211 (32%), Gaps = 29/211 (13%) Query: 35 YPCGKSAFVRCLDDG-----DSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGK 89 +P GK D S ++ GH V + S +CSG Sbjct: 274 HPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFS---LSFQCDGSLVCSGGMDSL 330 Query: 90 VIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDS 149 ++W + + PI ++W G ++ G G+ WD Sbjct: 331 SMLWDIR--------SGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGD----GIINVWDI 378 Query: 150 GNS----LGEVSGHSQRINACHL-KQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHK 204 L ++ H + K+ + ++ G D + Y + S H Sbjct: 379 RKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSLAGHT- 437 Query: 205 QGSFVRDVEFSPDSGEFVITVGSDRKISCFD 235 + ++ S +S F+++ G DR I ++ Sbjct: 438 --DKIISLDISNNSH-FLVSGGWDRSIKLWN 465 >6GMH-W nrPDB Length = 305 Score = 117 bits (292), Expect = 2e-26, Method: Composition-based stats. Identities = 57/285 (20%), Positives = 111/285 (38%), Gaps = 28/285 (9%) Query: 169 KQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSD 228 K+ +T D V ++ + + V V+ S + + D Sbjct: 28 KKENSETVVTGSLDDLVKVWKWRDERLDLQW-SLEGHQLGVVSVDIS-HTLPIAASSSLD 85 Query: 229 RKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQ 288 I +D ++G+ +K I D PV A S DSQ AT + ++ V + K + Sbjct: 86 AHIRLWDLENGKQIKSI--DAGPVDAWTLAFS-PDSQYLATGTHVGKVNIFGVESGK--K 140 Query: 289 KWTLDKQQLGNQQVGVVATGNG-RIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTV 347 +++LD + G + + + +G + S ++DG +N +++ ++L T+ GH I +LT Sbjct: 141 EYSLDTR--GKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTF 198 Query: 348 NP----LISGSYDGRIMEWS-----SSSMHQDHSNLIVSLDNSKAQEYS--------SIS 390 +P L++ S DG I + + H++ ++++ + Sbjct: 199 SPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKV 258 Query: 391 WDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLL-ILQS 434 WD + T + Q N +G V DD + I Sbjct: 259 WDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDC 303 Score = 83.4 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 51/216 (23%), Positives = 85/216 (39%), Gaps = 24/216 (11%) Query: 69 TVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEG 128 T+ FSP SQYL +G GKV ++G K+ S++ K I++ +G Sbjct: 111 TLAFSP--DSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILS--------IAYSPDG 160 Query: 129 RRLCVVGEGRDNFGVFISWD--SGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVV 186 + L G+ +D +G L + GH+ I + +T DDG + Sbjct: 161 KYLASGAID----GIINIFDIATGKLLHTLEGHAMPIRSLTFSPDS-QLLVTASDDGYIK 215 Query: 187 FYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIE 246 Y + T S+V +V F PD FV + + + +D + + Sbjct: 216 IYDVQHANLA---GTLSGHASWVLNVAFCPDDTHFVSSSSD-KSVKVWDVGTRTCVHTFF 271 Query: 247 DDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVT 282 D Q+ V G + + K +VG D I ++D Sbjct: 272 DHQDQVWGVKYN---GNGSKIVSVGDDQEIHIYDCP 304 Score = 71.9 bits (174), Expect = 8e-13, Method: Composition-based stats. Identities = 44/303 (14%), Positives = 121/303 (39%), Gaps = 42/303 (13%) Query: 249 QEPVQGGIFALSWLDSQK-----FATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVG 303 ++ I++++W ++K T D ++VW + +W+L+ QLG V Sbjct: 12 EQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVD 71 Query: 304 VVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRI 359 + T S SLD + ++L + + +K+I L +P L +G++ G++ Sbjct: 72 ISHTL-PIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKV 130 Query: 360 MEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGF 419 + S +++S +++ + SI++ + + + Sbjct: 131 NIFGVESGKKEYS------LDTRGKFILSIAY----------------------SPDGKY 162 Query: 420 TAVLTNDDDLLILQSFTGDIIKSVRLNS-PGSAVSLSQNYVAVG-LEEGNTIQVFKLSDL 477 A D + I TG ++ ++ ++ P +++ S + + + I+++ + Sbjct: 163 LASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHA 222 Query: 478 EVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAI 537 ++ L + + ++ P +T+ + + ++D+ +R + H ++ + Sbjct: 223 NLAGTL-SGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTC-VHTFFDHQDQVWGV 280 Query: 538 SWK 540 + Sbjct: 281 KYN 283 Score = 59.9 bits (143), Expect = 3e-09, Method: Composition-based stats. Identities = 55/291 (18%), Positives = 102/291 (35%), Gaps = 69/291 (23%) Query: 327 GHDEVLKTISGHNKGITALT--------VNPLISGSYDGRIMEW-------SSSSMHQDH 371 + + K H+ I ++ +++GS D + W + H Sbjct: 4 QYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGH 63 Query: 372 SNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLI 431 +VS+D S ++ S + D + + Sbjct: 64 QLGVVSVDISHTLPIAASS---------------------------------SLDAHIRL 90 Query: 432 LQSFTGDIIKSV---RLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLR 488 G IKS+ +++ A S Y+A G G + +F + + + L T R Sbjct: 91 WDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVG-KVNIFGVESGKKEYSLDT--R 147 Query: 489 AK-PSYISISPSETYIAAGDVMGKILLYDLQ-SREVKTSRWAFHTSKINAISWKPAEKGA 546 K I+ SP Y+A+G + G I ++D+ + + T H I ++++ P + Sbjct: 148 GKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHT--LEGHAMPIRSLTFSPDSQ-- 203 Query: 547 NEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPST 597 L+ T S D I IY V+ + L+ H V N+ + T Sbjct: 204 --------LLVTASDDGYIKIYDVQH-ANLAGTLSGHASWVLNVAFCPDDT 245 Score = 36.8 bits (83), Expect = 0.027, Method: Composition-based stats. Identities = 20/85 (23%), Positives = 40/85 (47%), Gaps = 8/85 (9%) Query: 530 HTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPM-KIIKALNAHKDGVN 588 H I +++W +K +E V TGSLD + ++ + + +L H+ GV Sbjct: 15 HDDAIWSVAWGTNKKENSET------VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVV 68 Query: 589 NLLWETPSTLVSSGA-DACIKRWNV 612 ++ + +S + DA I+ W++ Sbjct: 69 SVDISHTLPIAASSSLDAHIRLWDL 93 >5WYK-BB nrPDB Length = 943 Score = 115 bits (288), Expect = 4e-26, Method: Composition-based stats. Identities = 70/369 (18%), Positives = 123/369 (33%), Gaps = 49/369 (13%) Query: 15 STQRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGD-SKVPPVVQFTGHGSSVVTTVKFS 73 +T + L ++N I Y + + D + P+ T T V+ Sbjct: 344 TTVSSSKLELVLTTSSNTIEY------YSIPYEKRDPTSPAPLKTHTIELQGQRTDVRSI 397 Query: 74 PIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCV 133 I L + +G + +W K + E + L G L + Sbjct: 398 DISDDNKLLATASNGSLKIWNIKTHKCIRTFECGYALTCKFLPG-----------GLLVI 446 Query: 134 VGEGRDNFGVFISWDSGNSLGEVS---GHSQRINACHLKQSRPMRSMTVGDDGSVVFYQ- 189 +G G +D +S + H I + L S R +T D +V F+ Sbjct: 447 LGT---RNGELQLFDLASSSLLDTIEDAHDAAIWSLDLT-SDGKRLVTGSADKTVKFWDF 502 Query: 190 --------GPPFKFSASDRTHHKQ----GSFVRDVEFSPDSGEFVITVGSDRKISCFDGK 237 G KF + HH + V SPD I++ D + F Sbjct: 503 KVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISL-LDNTVKVFFLD 561 Query: 238 SGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQL 297 S +F + + PV + DS+ T AD I++W + C + + + Sbjct: 562 SMKFYLSLYGHKLPVLSIDISF---DSKMIITSSADKNIKIWGLDFGDCHKSLFAHQDSI 618 Query: 298 GNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISG 353 N + + S S D + +++ E ++ + H + AL V ++S Sbjct: 619 MNVK---FLPQSHNFFSCSKDAVVKYWDGEKFECIQKLYAHQSEVWALAVATDGGFVVSS 675 Query: 354 SYDGRIMEW 362 S+D I W Sbjct: 676 SHDHSIRIW 684 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 74/531 (13%), Positives = 153/531 (28%), Gaps = 85/531 (16%) Query: 142 GVFISWDSGNSLGEVSGHSQRI----NACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSA 197 + ++ + G ++ ++ + ++ + S P + +T + V + + Sbjct: 3 KSYQRFEQAAAFGVIASNANCVWIPASSGNSNGSGPGQLITSALED-VNIWDIKTGDLVS 61 Query: 198 SDRTHHKQGS-------FVRDVEFSPDSGEFVITVGS-DRKISCFDGKSGEFLKYIEDDQ 249 G+ ++ VG D I +D S L + Sbjct: 62 KLSDGLPPGASDARGAKPAECTYLEAHKDTDLLAVGYADGVIKVWDLMSKTVLLNFNGHK 121 Query: 250 EPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGN 309 + F + + D+ I VWD+ + K K + G Sbjct: 122 AAITLLQFD---GTGTRLISGSKDSNIIVWDLVGEVGLYKLRSHKDSITGFWC----QGE 174 Query: 310 GRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP--LISGSYDGRIMEWSSSSM 367 +IS S DG + ++L + ++T H L V LI+ D ++ W Sbjct: 175 DWLISTSKDGMIKLWDLKTHQCIETHIAHTGECWGLAVKDDLLITTGTDSQVKIWKL--- 231 Query: 368 HQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDD 427 D N + ++ + S LK+ + N D Sbjct: 232 --DIENDKMGGKLTEMGIFEKQSKQRGLKI-EFITNSSDKTSFFYIQNADKTIETFRIRK 288 Query: 428 DLLI----------------------------LQSFTGDIIKSVRLNSPGSAVS----LS 455 + I SF +++R + S S Sbjct: 289 EEEIARGLKKREKRLKEKGLTEEEIAKSIKESYSSFILHPFQTIRSLYKIKSASWTTVSS 348 Query: 456 QNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPL----------RAKPSYISISPSETYIAA 505 V NTI+ + + + PL R I IS +A Sbjct: 349 SKLELVLTTSSNTIEYYSIPYEKRDPTSPAPLKTHTIELQGQRTDVRSIDISDDNKLLAT 408 Query: 506 GDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNI 565 G + +++++ + + K LV G+ + + Sbjct: 409 AS-NGSLKIWNIK---------THKCIRTFECGYALTCKFLPGG----LLVILGTRNGEL 454 Query: 566 FIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSG-ADACIKRWNVVLE 615 ++ + + +AH + +L + + +G AD +K W+ +E Sbjct: 455 QLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVE 505 Score = 99 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 110/666 (16%), Positives = 214/666 (32%), Gaps = 113/666 (16%) Query: 10 IPPQPSTQRNF----TTHLSYDPTTN--AIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHG 63 +PP S R T+L T+ A+ Y G ++ D V ++ F GH Sbjct: 67 LPPGASDARGAKPAECTYLEAHKDTDLLAVGYADG---VIKVWDLMSKTV--LLNFNGHK 121 Query: 64 SSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDIS 123 + +T ++F L SG + +IVW + + + K Sbjct: 122 A-AITLLQFD--GTGTRLISGSKDSNIIVWDLVGEVGLYKL-RSHKDSITGF-------- 169 Query: 124 WDFEGRRLCVVGEGRDNFGVFISWD--SGNSLGEVSGHSQRINACHLKQSRPMRSMTVGD 181 W L + G+ WD + + H+ +K +T G Sbjct: 170 WCQGEDWLISTSKD----GMIKLWDLKTHQCIETHIAHTGECWGLAVKDD---LLITTGT 222 Query: 182 DGSVVFY---------QGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKIS 232 D V + G + ++ ++G + + S D F +D+ I Sbjct: 223 DSQVKIWKLDIENDKMGGKLTEMGIFEKQSKQRGLKIEFITNSSDKTSFFYIQNADKTIE 282 Query: 233 CFDGKSGEFLKY-------------------IEDDQEPVQGGIFAL-------------S 260 F + E + + +E I S Sbjct: 283 TFRIRKEEEIARGLKKREKRLKEKGLTEEEIAKSIKESYSSFILHPFQTIRSLYKIKSAS 342 Query: 261 WLDSQK----FATVGADATIRVW-------DVTTSKCVQKWTLDKQQLGNQQVGVVATGN 309 W + TI + D T+ ++ T++ Q + + + Sbjct: 343 WTTVSSSKLELVLTTSSNTIEYYSIPYEKRDPTSPAPLKTHTIELQGQRTDVRSIDISDD 402 Query: 310 GRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSS 365 ++++ + +G+L + + + ++T P +I G+ +G + + + Sbjct: 403 NKLLATASNGSLKIWNIKTHKCIRTFE--CGYALTCKFLPGGLLVILGTRNGELQLFDLA 460 Query: 366 SMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTN 425 S S+L+ +++ A + + S D T + K + T Sbjct: 461 S-----SSLLDTIE--DAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVENSLVPGTK 513 Query: 426 DDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKT 485 + L +L+ D + + VS Y+A+ L + NT++VF L ++ L Sbjct: 514 NKFLPVLKLHH-DTTLELTDDILCVRVSPDDRYLAISLLD-NTVKVFFLDSMKFYLSLYG 571 Query: 486 PLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKG 545 + I IS I I ++ L + S +A H I + + P Sbjct: 572 H-KLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKSLFA-HQDSIMNVKFLPQSHN 629 Query: 546 ANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPST-LVSSGAD 604 + S D + + ++ + I+ L AH+ V L T +VSS D Sbjct: 630 ----------FFSCSKDAVVKYWDGEK-FECIQKLYAHQSEVWALAVATDGGFVVSSSHD 678 Query: 605 ACIKRW 610 I+ W Sbjct: 679 HSIRIW 684 Score = 98.8 bits (244), Expect = 6e-21, Method: Composition-based stats. Identities = 48/350 (13%), Positives = 108/350 (30%), Gaps = 38/350 (10%) Query: 81 LCSGDESGKVIVWGWTFDKESNSVEVNVKS---EFQVLAGPISDISWDFEGRRLCVVGEG 137 L S + + ++K + +K+ E Q + I + + L Sbjct: 353 LVLTTSSNTIEYYSIPYEKRDPTSPAPLKTHTIELQGQRTDVRSIDISDDNKLLATASN- 411 Query: 138 RDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSA 197 G W+ + C + + +G + + Sbjct: 412 ----GSLKIWNIKTHKCIRTFECGYALTCKFLPGG-LLVILGTRNGELQLFDLASSSLLD 466 Query: 198 SDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGE------------FLKYI 245 + + + ++ + D G+ ++T +D+ + +D K LK Sbjct: 467 TIED--AHDAAIWSLDLTSD-GKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLH 523 Query: 246 EDDQEPVQGGIFAL-SWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGV 304 D + I + D + A D T++V+ + + K K + + + Sbjct: 524 HDTTLELTDDILCVRVSPDDRYLAISLLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISF 583 Query: 305 VATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIM 360 + II+ S D + + L + K++ H I + P S S D + Sbjct: 584 ---DSKMIITSSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQSHNFFSCSKDAVVK 640 Query: 361 EWSSSS-----MHQDHSNLIVSLD-NSKAQEYSSISWDDTLKVNGITKHE 404 W H + + +L + S S D ++++ T+ + Sbjct: 641 YWDGEKFECIQKLYAHQSEVWALAVATDGGFVVSSSHDHSIRIWEETEDQ 690 Score = 94.2 bits (232), Expect = 1e-19, Method: Composition-based stats. Identities = 83/529 (15%), Positives = 169/529 (31%), Gaps = 85/529 (16%) Query: 142 GVFISWD--SGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASD 199 GV WD S L +GH I R ++ D +++ + Sbjct: 101 GVIKVWDLMSKTVLLNFNGHKAAITLLQFD-GTGTRLISGSKDSNIIVWDLVGEVGLYKL 159 Query: 200 RTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFAL 259 R+H + +++I+ D I +D K+ + ++ G + L Sbjct: 160 RSHKDSITGFWC-----QGEDWLISTSKDGMIKLWDLKTHQCIETHIAHT----GECWGL 210 Query: 260 SWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNG-RIISLSLD 318 + D T D+ +++W + K ++G + G I+ S D Sbjct: 211 AVKDDLLITTGT-DSQVKIWKLDIEN--DKMGGKLTEMGIFEKQSKQRGLKIEFITNSSD 267 Query: 319 GTLNFYELGHDEVLKTISGHNK------------------------------GITALTVN 348 T FY D+ ++T + ++ ++ Sbjct: 268 KTSFFYIQNADKTIETFRIRKEEEIARGLKKREKRLKEKGLTEEEIAKSIKESYSSFILH 327 Query: 349 PLIS--GSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISW---DDT----LKVNG 399 P + Y + W++ S + L S S EY SI + D T LK + Sbjct: 328 PFQTIRSLYKIKSASWTTVSSSKLELVLTTS---SNTIEYYSIPYEKRDPTSPAPLKTHT 384 Query: 400 ITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYV 459 I + + ++D ++ L I T I++ + L + Sbjct: 385 IELQGQRTDVRSIDISDDNKLLATASNGSLKIWNIKTHKCIRTFECGYALTCKFLPGGLL 444 Query: 460 AVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQS 519 + +Q+F L+ + ++ A + ++ + G + +D + Sbjct: 445 VILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKV 504 Query: 520 RE----VKTSRW----AFH-------TSKINAISWKPAEKGANEEEIEEDLVATGSLDTN 564 +++ H T I + P ++ +A LD Sbjct: 505 ENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRY----------LAISLLDNT 554 Query: 565 IFIYSVKRPMKIIKALNAHKDGVNNLLWETPST-LVSSGADACIKRWNV 612 + ++ + MK +L HK V ++ S +++S AD IK W + Sbjct: 555 VKVFFLD-SMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGL 602 Score = 29.1 bits (63), Expect = 5.1, Method: Composition-based stats. Identities = 13/64 (20%), Positives = 22/64 (34%), Gaps = 5/64 (7%) Query: 35 YPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWG 94 + C K A V+ D K + + H S V + ++ S + +W Sbjct: 631 FSCSKDAVVKYWD--GEKFECIQKLYAHQSEVW---ALAVATDGGFVVSSSHDHSIRIWE 685 Query: 95 WTFD 98 T D Sbjct: 686 ETED 689 >5XYI-g nrPDB Length = 335 Score = 115 bits (286), Expect = 9e-26, Method: Composition-based stats. Identities = 37/260 (14%), Positives = 93/260 (35%), Gaps = 24/260 (9%) Query: 153 LGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFK--FSASDRTHHKQGSFVR 210 GH+ I + + + D S + ++ + ++ FV Sbjct: 26 RATFVGHNAAIESIEIDNEHNYLV-SASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVS 84 Query: 211 DVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATV 270 DV S D+ ++T D + +D + K ++ V G F+ +++ +V Sbjct: 85 DVSLSRDA-SHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPC---NRRIISV 140 Query: 271 GADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGR----IISLSLDGTLNFYEL 326 G D +++W++ + + V + I DG + + + Sbjct: 141 GRDNQVKIWNILGENKAEL----QCSSWVTSVACAPMADETSPLVIAVGCWDGKVYIWSI 196 Query: 327 -GHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQDHS----NLIVS 377 +++K H+ T++ P +I+G D +++ W + + + S + + + Sbjct: 197 EKEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGAKTISFTAPSPVHA 256 Query: 378 LDNSKAQEYSSISWDDTLKV 397 + Q + + + + V Sbjct: 257 VAACPTQAWICAATYEGIAV 276 Score = 82.3 bits (201), Expect = 6e-16, Method: Composition-based stats. Identities = 51/337 (15%), Positives = 99/337 (29%), Gaps = 50/337 (14%) Query: 55 PVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQV 114 P F GH ++ + +++ YL S +VW +E + + Sbjct: 25 PRATFVGH-NAAIESIEID--NEHNYLVSASRDKSALVWKLNRTQEQWATPF---TRLIG 78 Query: 115 LAGPISDISWDFEGRRLCVVGEGRDNFGVFISWD--SGNSLGEVSGHSQRINACHLKQSR 172 +SD+S + L WD + + GH + + Sbjct: 79 HNHFVSDVSLSRDASHLLTSSWD----STLRLWDLSTRTTKKLFLGHKKDVLGVTFSPC- 133 Query: 173 PMRSMTVGDDGSVVFYQ-----GPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVIT-VG 226 R ++VG D V + + S+ + V + ++ VI Sbjct: 134 NRRIISVGRDNQVKIWNILGENKAELQCSSWV-------TSVACAPMADETSPLVIAVGC 186 Query: 227 SDRKISCFDGKSG-EFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSK 285 D K+ + + + +K + F D + T G+D + +W Sbjct: 187 WDGKVYIWSIEKEAKLIKEFKAHDGRCTSVDFT---PDGKWVITGGSDRKVVMWLTENGA 243 Query: 286 CVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTIS--------- 336 +T I + + +G + +++G + + + Sbjct: 244 KTISFTAPSPVHAVAAC----PTQAWICAATYEG-IAVWDIGAKQQIDLVQPNFKHEGKR 298 Query: 337 --GHNKGITALTV----NPLISGSYDGRIMEWSSSSM 367 G T L + L SG DG I W S Sbjct: 299 NAGRTPDCTCLAWAADGSVLYSGYNDGSIRAWEVKSA 335 Score = 76.5 bits (186), Expect = 3e-14, Method: Composition-based stats. Identities = 55/353 (15%), Positives = 114/353 (32%), Gaps = 70/353 (19%) Query: 243 KYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDV-TTSKCVQK--WTLDKQQLGN 299 ++ + + D + VW + T + L Sbjct: 27 ATFVGHNAAIESIEIDN---EHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFV 83 Query: 300 QQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSY 355 V + +++ S D TL ++L K GH K + +T +P +IS Sbjct: 84 SDVSLS-RDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIISVGR 142 Query: 356 DGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASAN 415 D ++ W+ I+ + ++ Q SW ++ + P V Sbjct: 143 DNQVKIWN-----------ILGENKAELQ---CSSWVTSV---ACAPMADETSPLV---- 181 Query: 416 NDGFTAVLTNDDDLLILQSFT-GDIIKSVRLNS---PGSAVSLSQNYVAVGLEEGNTIQV 471 AV D + I +IK + + + +V G + + Sbjct: 182 ----IAVGCWDGKVYIWSIEKEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMW 237 Query: 472 FKLSDLE-VSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSR---------- 520 + + +SF +P+ A ++ P++ +I A G I ++D+ ++ Sbjct: 238 LTENGAKTISFTAPSPVHA----VAACPTQAWICAATYEG-IAVWDIGAKQQIDLVQPNF 292 Query: 521 --EVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVK 571 E K + A T ++W + ++ +G D +I + VK Sbjct: 293 KHEGKRN--AGRTPDCTCLAWAA----------DGSVLYSGYNDGSIRAWEVK 333 Score = 41.4 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 23/132 (17%), Positives = 46/132 (34%), Gaps = 16/132 (12%) Query: 489 AKPSYISISPSETYIAAGDVMGKILLYDLQSREVK----TSRWAFHTSKINAISWKPAEK 544 A I I Y+ + L++ L + + +R H ++ +S Sbjct: 34 AAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVSLSRDAS 93 Query: 545 GANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWE-TPSTLVSSGA 603 + T S D+ + ++ + K HK V + + ++S G Sbjct: 94 H----------LLTSSWDSTLRLWDLS-TRTTKKLFLGHKKDVLGVTFSPCNRRIISVGR 142 Query: 604 DACIKRWNVVLE 615 D +K WN++ E Sbjct: 143 DNQVKIWNILGE 154 >6QDV-o nrPDB Length = 513 Score = 111 bits (278), Expect = 7e-25, Method: Composition-based stats. Identities = 46/319 (14%), Positives = 101/319 (31%), Gaps = 31/319 (9%) Query: 56 VVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVL 115 + ++GH + V+ V+ P+ G L S K+ +W ++ F Sbjct: 215 IHVWSGH-TKGVSAVRLFPLSG-HLLLSCSMDCKIKLWEVYGERR-------CLRTFIGH 265 Query: 116 AGPISDISWDFEGRRLCVVGEGRDNFGVFISWDS--GNSLGEVSGHSQRINACHLKQSRP 173 + + DI ++ G + R WD+ G + + Sbjct: 266 SKAVRDICFNTAGTQFLSAAYDR----YLKLWDTETGQCISRFTNRKVP-YCVKFNPDED 320 Query: 174 MRSMTVGD--DGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKI 231 +++ V D +V + + H + + V D ++ D+ + Sbjct: 321 KQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFV----DENRRFVSTSDDKSL 376 Query: 232 SCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTS-KCVQKW 290 ++ KYI + + + + A D I ++ + +K Sbjct: 377 RVWEWDIPVDFKYIA--EPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKK 434 Query: 291 TLDKQQLGNQQVGVVATGN-GRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP 349 + V + + +IS +G LN ++ ++ H+K +P Sbjct: 435 IFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHP 494 Query: 350 -----LISGSYDGRIMEWS 363 +I+ +DG I W Sbjct: 495 HETSKVITCGWDGLIKLWD 513 Score = 96.9 bits (239), Expect = 2e-20, Method: Composition-based stats. Identities = 53/257 (20%), Positives = 98/257 (38%), Gaps = 23/257 (8%) Query: 157 SGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSP 216 SGH++ ++A L ++ D + ++ + RT VRD+ F+ Sbjct: 219 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGER--RCLRTFIGHSKAVRDICFNT 276 Query: 217 DSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATI 276 +G ++ DR + +D ++G+ + + + P F F +D I Sbjct: 277 -AGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVP-YCVKFNPDEDKQNLFVAGMSDKKI 334 Query: 277 RVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYEL---GHDEVLK 333 WD+ + + VQ++ LG V N R +S S D +L +E + + Sbjct: 335 VQWDIRSGEIVQEYDRH---LGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIA 391 Query: 334 TISGHNKGITALTVNP--LISGSYDGRIMEW--------SSSSMHQDH--SNLIVSLDNS 381 S H+ L+ N L S D +I+ + + + + H + +D S Sbjct: 392 EPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFS 451 Query: 382 KAQEYSSISWDDTLKVN 398 Y IS D K+N Sbjct: 452 PDMSYV-ISGDGNGKLN 467 Score = 96.9 bits (239), Expect = 2e-20, Method: Composition-based stats. Identities = 55/338 (16%), Positives = 121/338 (35%), Gaps = 52/338 (15%) Query: 288 QKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYEL-GHDEVLKTISGHNKGITALT 346 Q G V + ++S S+D + +E+ G L+T GH+K + + Sbjct: 214 QIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDIC 273 Query: 347 VN----PLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITK 402 N +S +YD + W + + IS KV K Sbjct: 274 FNTAGTQFLSAAYDRYLKLWDTETGQ-------------------CISRFTNRKVPYCVK 314 Query: 403 HEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVR--LNSPGSAVSLSQNYVA 460 + +D ++ +G+I++ L + + V + +N Sbjct: 315 FNPDEDKQNL-------FVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRF 367 Query: 461 VGLEEGNTIQVFKLS-DLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQS 519 V + +++V++ ++ + + + + P+ +++SP+ ++A + +IL++ Q+ Sbjct: 368 VSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPA-VTLSPNGKWLACQSMDNQILIFGAQN 426 Query: 520 --REVKTSRWAFHTSKIN--AISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMK 575 R K + H + + P V +G + + I+ + K Sbjct: 427 RFRLNKKKIFKGHMVAGYACQVDFSPDMSY----------VISGDGNGKLNIWD-WKTTK 475 Query: 576 IIKALNAHKDGVNNLLW--ETPSTLVSSGADACIKRWN 611 + AH +W S +++ G D IK W+ Sbjct: 476 LYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 513 >5YZG-W nrPDB Length = 579 Score = 111 bits (276), Expect = 1e-24, Method: Composition-based stats. Identities = 46/319 (14%), Positives = 101/319 (31%), Gaps = 31/319 (9%) Query: 56 VVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVL 115 + ++GH + V+ V+ P+ G L S K+ +W ++ F Sbjct: 281 IHVWSGH-TKGVSAVRLFPLSG-HLLLSCSMDCKIKLWEVYGERR-------CLRTFIGH 331 Query: 116 AGPISDISWDFEGRRLCVVGEGRDNFGVFISWDS--GNSLGEVSGHSQRINACHLKQSRP 173 + + DI ++ G + R WD+ G + + Sbjct: 332 SKAVRDICFNTAGTQFLSAAYDR----YLKLWDTETGQCISRFTNRKVP-YCVKFNPDED 386 Query: 174 MRSMTVGD--DGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKI 231 +++ V D +V + + H + + V D ++ D+ + Sbjct: 387 KQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFV----DENRRFVSTSDDKSL 442 Query: 232 SCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTS-KCVQKW 290 ++ KYI + + + + A D I ++ + +K Sbjct: 443 RVWEWDIPVDFKYIA--EPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKK 500 Query: 291 TLDKQQLGNQQVGVVATGN-GRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP 349 + V + + +IS +G LN ++ ++ H+K +P Sbjct: 501 IFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHP 560 Query: 350 -----LISGSYDGRIMEWS 363 +I+ +DG I W Sbjct: 561 HETSKVITCGWDGLIKLWD 579 Score = 96.5 bits (238), Expect = 3e-20, Method: Composition-based stats. Identities = 53/257 (20%), Positives = 98/257 (38%), Gaps = 23/257 (8%) Query: 157 SGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSP 216 SGH++ ++A L ++ D + ++ + RT VRD+ F+ Sbjct: 285 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGER--RCLRTFIGHSKAVRDICFNT 342 Query: 217 DSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATI 276 +G ++ DR + +D ++G+ + + + P F F +D I Sbjct: 343 -AGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVP-YCVKFNPDEDKQNLFVAGMSDKKI 400 Query: 277 RVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYEL---GHDEVLK 333 WD+ + + VQ++ LG V N R +S S D +L +E + + Sbjct: 401 VQWDIRSGEIVQEYDRH---LGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIA 457 Query: 334 TISGHNKGITALTVNP--LISGSYDGRIMEW--------SSSSMHQDH--SNLIVSLDNS 381 S H+ L+ N L S D +I+ + + + + H + +D S Sbjct: 458 EPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFS 517 Query: 382 KAQEYSSISWDDTLKVN 398 Y IS D K+N Sbjct: 518 PDMSYV-ISGDGNGKLN 533 Score = 96.1 bits (237), Expect = 4e-20, Method: Composition-based stats. Identities = 55/338 (16%), Positives = 121/338 (35%), Gaps = 52/338 (15%) Query: 288 QKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYEL-GHDEVLKTISGHNKGITALT 346 Q G V + ++S S+D + +E+ G L+T GH+K + + Sbjct: 280 QIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDIC 339 Query: 347 VN----PLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITK 402 N +S +YD + W + + IS KV K Sbjct: 340 FNTAGTQFLSAAYDRYLKLWDTETGQ-------------------CISRFTNRKVPYCVK 380 Query: 403 HEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVR--LNSPGSAVSLSQNYVA 460 + +D ++ +G+I++ L + + V + +N Sbjct: 381 FNPDEDKQNL-------FVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRF 433 Query: 461 VGLEEGNTIQVFKLS-DLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQS 519 V + +++V++ ++ + + + + P+ +++SP+ ++A + +IL++ Q+ Sbjct: 434 VSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPA-VTLSPNGKWLACQSMDNQILIFGAQN 492 Query: 520 --REVKTSRWAFHTSKIN--AISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMK 575 R K + H + + P V +G + + I+ + K Sbjct: 493 RFRLNKKKIFKGHMVAGYACQVDFSPDMSY----------VISGDGNGKLNIWD-WKTTK 541 Query: 576 IIKALNAHKDGVNNLLW--ETPSTLVSSGADACIKRWN 611 + AH +W S +++ G D IK W+ Sbjct: 542 LYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 579 >5OQL-L nrPDB Length = 557 Score = 110 bits (275), Expect = 2e-24, Method: Composition-based stats. Identities = 50/291 (17%), Positives = 101/291 (34%), Gaps = 25/291 (8%) Query: 95 WTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGV-------FISW 147 W K+ S ++ P S + L + D F V S Sbjct: 27 WRSFKKQKSHTSTANWPISHISFPASLGTTALVSSSLVAAAKTNDLFAVTAGPRVEIFSI 86 Query: 148 DSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDD-GSVVFYQGPPFKFSASDRTHHKQG 206 L + + ++ R + G+D G + + + +T H Sbjct: 87 RKREPLKTIGRFDSEAHCGEIRPDG--RVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHK 144 Query: 207 SFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQK 266 V ++SP +++ D+ + +D S + + + V+ G F +S Sbjct: 145 QPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSANSNL 204 Query: 267 FATVGADATIRVWDVTT-SKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYE 325 + D T+RVWD V + K + V + +G + + ++ + Sbjct: 205 LVSGSYDETVRVWDARAPGGAVMTF---KHADPIEDVLPLPSGTTLLAASG--NAISVLD 259 Query: 326 LGHDEVLKTISGHNKGITALTVN----PLISGSYDGRIME-----WSSSSM 367 L + L+ I+ H K +T+L++ ++SGS DG + W+ + Sbjct: 260 LVAAKPLRLITNHQKTVTSLSLASQGRRVVSGSLDGHVKVFETTSWNVVAG 310 Score = 76.1 bits (185), Expect = 4e-14, Method: Composition-based stats. Identities = 55/339 (16%), Positives = 110/339 (32%), Gaps = 50/339 (14%) Query: 12 PQPSTQ-----RNFTTHLSYDPTTN----AIAYPC--GKSAFVRCLDDGDSKVPPVVQFT 60 P P T R+F S+ T N I++P G +A V +K + T Sbjct: 17 PSPITAEQRYWRSFKKQKSHTSTANWPISHISFPASLGTTALVSSSLVAAAKTNDLFAVT 76 Query: 61 -GHGSSVVTTVKFSPIK----------------GSQYLCSGDESGKVIVWGWTFDKESNS 103 G + + K P+K + L +G+++G++ V+ Sbjct: 77 AGPRVEIFSIRKREPLKTIGRFDSEAHCGEIRPDGRVLVAGEDTGRMQVFDV-----GQG 131 Query: 104 VEVNVKSEFQVLAGPISDISWD-FEGRRLCVVGEGRDNFGVFISWD--SGNSLGEVSGHS 160 + + + P+ W E L + + WD S + +GH+ Sbjct: 132 TRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDK----TVRLWDLPSNDPTRLFTGHT 187 Query: 161 QRINACHLKQS--RPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDS 218 + ++ D +V + + T K + DV P Sbjct: 188 DYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAP--GGAVMTF-KHADPIEDVLPLPSG 244 Query: 219 GEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRV 278 + G IS D + + L+ I + Q+ V A ++ + D ++V Sbjct: 245 TTLLAASG--NAISVLDLVAAKPLRLITNHQKTVTSLSLA---SQGRRVVSGSLDGHVKV 299 Query: 279 WDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSL 317 ++ T+ V L + A+ + R +++ + Sbjct: 300 FETTSWNVVAGAKYPSPILSLSVITAGASHDDRHLAVGM 338 Score = 57.2 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 37/282 (13%), Positives = 87/282 (30%), Gaps = 40/282 (14%) Query: 247 DDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVA 306 V + A + + T G + ++ + + ++ + G + Sbjct: 54 GTTALVSSSLVAAAKTNDLFAVTAGP--RVEIFSIRKREPLKTI---GRFDSEAHCGEIR 108 Query: 307 TGNGRIISLSLDGTLNFYELGHDE---VLKTISGHNKGITALTVNP-----LISGSYDGR 358 +++ G + +++G +LKT H + + +P L+S S D Sbjct: 109 PDGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKT 168 Query: 359 IMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDD-TLKVNGITKHEFGSQPKVASANND 417 + W S L ++ + N + + +V A Sbjct: 169 VRLWDLPSNDP------TRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAP 222 Query: 418 GFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDL 477 G + D + + + + + A S GN I V L Sbjct: 223 GGAVMTFKHADPI-------EDVLPLPSGTTLLAAS------------GNAISVLDLVAA 263 Query: 478 EVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQS 519 + L T + + +S++ + +G + G + +++ S Sbjct: 264 K-PLRLITNHQKTVTSLSLASQGRRVVSGSLDGHVKVFETTS 304 Score = 54.2 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 49/260 (18%), Positives = 100/260 (38%), Gaps = 29/260 (11%) Query: 360 MEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGF 419 W S + H+ ++ S IS+ +L + S VA+A + Sbjct: 25 RYWRSFKKQKSHT-------STANWPISHISFPASLGTTALV-----SSSLVAAAKTNDL 72 Query: 420 TAVLTNDDDLLILQSFTGDIIKSV---RLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSD 476 AV + I + +K++ + + V V E+ +QVF + Sbjct: 73 FAVTAGPR-VEIFSIRKREPLKTIGRFDSEAHCGEIRPDGR-VLVAGEDTGRMQVFDVGQ 130 Query: 477 LEVSFDLKT-PLRAKPSYIS-ISPSE-TYIAAGDVMGKILLYDLQSREVKTSRWAFHTSK 533 + LKT + +P +++ SP+E T + + + L+DL S + T + HT Sbjct: 131 GTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSND-PTRLFTGHTDY 189 Query: 534 INAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWE 593 + ++ P +N L+ +GS D + ++ + P + H D + ++L Sbjct: 190 VRCGAFMPGSANSN-------LLVSGSYDETVRVWDARAPGGAVMTFK-HADPIEDVLPL 241 Query: 594 TPSTLVSSGADACIKRWNVV 613 T + + + I ++V Sbjct: 242 PSGTTLLAASGNAISVLDLV 261 >3JB9-g nrPDB Length = 558 Score = 108 bits (270), Expect = 6e-24, Method: Composition-based stats. Identities = 55/334 (16%), Positives = 115/334 (34%), Gaps = 44/334 (13%) Query: 196 SASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDG-KSGEFLKYIEDDQEPVQG 254 T + + F P SG +++ D +I ++ L+ + P++ Sbjct: 256 KKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRD 315 Query: 255 GIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIIS 314 F+ D + F + D TI++WD KC+ + D+ + V ++ Sbjct: 316 LSFS---QDGRSFLSTSFDKTIKLWDTELGKCLNCFNSDR-LTNCVKFQVDPDKPNEFLA 371 Query: 315 LSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPLISGSYDGRIMEWSSSSMHQDHSNL 374 + D + +++ ++++ H GI ++T ++ Sbjct: 372 GTADKRILQFDIRSPDIVQAYDHHLGGINSITF--------------------LENGKRF 411 Query: 375 IVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQS 434 + + D+S + + + + + + S P+VA N A + D+ + + + Sbjct: 412 VTTSDDSSMRFW---EYGTPVPIKFVADIAMHSMPRVALRPNGKSIACQSLDNCIYVYSA 468 Query: 435 FTG--DIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKT------- 485 + K V S SL + +G + S +D KT Sbjct: 469 YEKYRQNKKKVFKGYSCSGYSLEVGF----SPDGRFVFSGDSSGNACFWDWKTCKLMAKL 524 Query: 486 PLRAKP-SYISISPSETYIAAGD--VMGKILLYD 516 P + P ++ P ET A V G I +D Sbjct: 525 PAHSGPVQSMAFHPQETSKVATSSIVDGSIKYWD 558 Score = 107 bits (267), Expect = 1e-23, Method: Composition-based stats. Identities = 51/320 (15%), Positives = 110/320 (34%), Gaps = 32/320 (10%) Query: 56 VVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVL 115 + + GH + ++ ++F PI G L SG ++ +W D ++ FQ Sbjct: 259 IFTWKGH-TKGISCLRFFPISG-HLLLSGSMDNQIKIWEVYHD-------RSLLRTFQGH 309 Query: 116 AGPISDISWDFEGRRLCVVGEGRDNFGVFISWDS--GNSLGEVSGHSQRINACHL--KQS 171 A PI D+S+ +GR + WD+ G L + N Sbjct: 310 ARPIRDLSFSQDGRSFLSTSFDK----TIKLWDTELGKCL-NCFNSDRLTNCVKFQVDPD 364 Query: 172 RPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKI 231 +P + D ++ + + H + + + ++G+ +T D + Sbjct: 365 KPNEFLAGTADKRILQFDIRSPDIVQAYDHHLGGINSITFL----ENGKRFVTTSDDSSM 420 Query: 232 SCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWD-VTTSKCVQKW 290 ++ + +K++ D + + + A D I V+ + +K Sbjct: 421 RFWEYGTPVPIKFVAD--IAMHSMPRVALRPNGKSIACQSLDNCIYVYSAYEKYRQNKKK 478 Query: 291 TLDKQQLGNQQVGVVATGNGRII-SLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP 349 + V + +GR + S G F++ +++ + H+ + ++ +P Sbjct: 479 VFKGYSCSGYSLEVGFSPDGRFVFSGDSSGNACFWDWKTCKLMAKLPAHSGPVQSMAFHP 538 Query: 350 ------LISGSYDGRIMEWS 363 S DG I W Sbjct: 539 QETSKVATSSIVDGSIKYWD 558 Score = 94.2 bits (232), Expect = 2e-19, Method: Composition-based stats. Identities = 44/224 (19%), Positives = 86/224 (38%), Gaps = 12/224 (5%) Query: 157 SGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSP 216 GH++ I+ ++ D + ++ + RT +RD+ FS Sbjct: 263 KGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSL--LRTFQGHARPIRDLSFSQ 320 Query: 217 DSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATI 276 D G ++ D+ I +D + G+ L D+ F + +F AD I Sbjct: 321 D-GRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLT-NCVKFQVDPDKPNEFLAGTADKRI 378 Query: 277 RVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHD---EVLK 333 +D+ + VQ + D G + + G R ++ S D ++ F+E G + + Sbjct: 379 LQFDIRSPDIVQAY--DHHLGGINSITFLENG-KRFVTTSDDSSMRFWEYGTPVPIKFVA 435 Query: 334 TISGHNKGITALTVN--PLISGSYDGRIMEWSSSSMHQDHSNLI 375 I+ H+ AL N + S D I +S+ ++ + + Sbjct: 436 DIAMHSMPRVALRPNGKSIACQSLDNCIYVYSAYEKYRQNKKKV 479 Score = 51.8 bits (122), Expect = 8e-07, Method: Composition-based stats. Identities = 21/93 (22%), Positives = 38/93 (40%), Gaps = 10/93 (10%) Query: 523 KTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNA 582 W HT I+ + + P I L+ +GS+D I I+ V +++ Sbjct: 258 HIFTWKGHTKGISCLRFFP---------ISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQG 308 Query: 583 HKDGVNNLLWETPS-TLVSSGADACIKRWNVVL 614 H + +L + + +S+ D IK W+ L Sbjct: 309 HARPIRDLSFSQDGRSFLSTSFDKTIKLWDTEL 341 Score = 50.3 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 23/125 (18%), Positives = 47/125 (37%), Gaps = 12/125 (9%) Query: 488 RAKP-SYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGA 546 A+P +S S + I L+D + K N + ++ Sbjct: 309 HARPIRDLSFSQDGRSFLSTSFDKTIKLWD--TELGKCLNCFNSDRLTNCVKFQVDPDKP 366 Query: 547 NEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTL-VSSGADA 605 NE G+ D I + ++ P I++A + H G+N++ + V++ D+ Sbjct: 367 NE-------FLAGTADKRILQFDIRSP-DIVQAYDHHLGGINSITFLENGKRFVTTSDDS 418 Query: 606 CIKRW 610 ++ W Sbjct: 419 SMRFW 423 >3FM0-A nrPDB Length = 345 Score = 108 bits (270), Expect = 6e-24, Method: Composition-based stats. Identities = 48/323 (14%), Positives = 93/323 (28%), Gaps = 45/323 (13%) Query: 72 FSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQ-VLAGPISDISWDFEGRR 130 + L S ++ +WG D KS + ++W G Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGD------SWICKSVLSEGHQRTVRKVAWSPCGNY 75 Query: 131 LCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQG 190 L + D + + GH + + S + + T D SV ++ Sbjct: 76 LASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLA-TCSRDKSVWVWEV 134 Query: 191 PPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGE--FLKYIEDD 248 + V+ V + P S E + + D + + + + +E Sbjct: 135 DEEDEYECVSVLNSHTQDVKHVVWHP-SQELLASASYDDTVKLYREEEDDWVCCATLEGH 193 Query: 249 QEPVQGGIFALSWLDSQKFATVGADATIRVW---------------DVTTSKCVQKWTLD 293 + V F S Q+ A+ D T+R+W + KC+ + Sbjct: 194 ESTVWSLAFDPS---GQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGF 250 Query: 294 KQQLGNQQVGVVATGNGRIISLSLDGTLNFY------ELGHDE---VLKTISGHNKGITA 344 + TG + + D + + + H++ + Sbjct: 251 HSRTIYDIAWCQLTGA--LATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNC 308 Query: 345 LTVNP-----LISGSYDGRIMEW 362 + NP L S S DG + W Sbjct: 309 VAWNPKEPGLLASCSDDGEVAFW 331 Score = 96.9 bits (239), Expect = 2e-20, Method: Composition-based stats. Identities = 48/336 (14%), Positives = 111/336 (33%), Gaps = 35/336 (10%) Query: 122 ISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEV-SGHSQRINACHLKQSRPMRSMTVG 180 ++W+ G L G R DS + GH + + + + Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLA-SAS 80 Query: 181 DDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSG- 239 D + ++ F T + V+ V ++P SG + T D+ + ++ Sbjct: 81 FDATTCIWKKNQDDF-ECVTTLEGHENEVKSVAWAP-SGNLLATCSRDKSVWVWEVDEED 138 Query: 240 --EFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQL 297 E + + + V+ ++ S + A+ D T++++ V TL+ + Sbjct: 139 EYECVSVLNSHTQDVKHVVWHPSQ---ELLASASYDDTVKLYREEEDDWVCCATLEGHES 195 Query: 298 GNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPLISGSYDG 357 + +G R+ S S D T+ + + + G+ +G+ +P Sbjct: 196 TVWSLAFDPSGQ-RLASCSDDRTVRIW-------RQYLPGNEQGVACSGSDP-------- 239 Query: 358 RIMEWSSSSMHQD-HSNLIVSLDNSKA-QEYSSISWDDTLKVNGITKHEFGSQPKVASAN 415 W HS I + + ++ DD ++V + + S P+ + + Sbjct: 240 ---SWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRV---FQEDPNSDPQQPTFS 293 Query: 416 NDGFTAVLTNDD-DLLILQSFTGDIIKSVRLNSPGS 450 + D + + ++ S + + Sbjct: 294 LTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVA 329 Score = 95.8 bits (236), Expect = 6e-20, Method: Composition-based stats. Identities = 65/344 (18%), Positives = 114/344 (33%), Gaps = 36/344 (10%) Query: 10 IPPQPSTQRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTT 69 +P P ++ F L+++P +A G +GDS + V GH T Sbjct: 11 VPAHPDSRCWF---LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGH---QRTV 64 Query: 70 VKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGR 129 K + YL S +W D + + + + ++W G Sbjct: 65 RKVAWSPCGNYLASASFDATTCIWKKNQD------DFECVTTLEGHENEVKSVAWAPSGN 118 Query: 130 RLCVVGEGRDNF-GVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFY 188 L + + D + ++ H+Q + S+ + + + D +V Y Sbjct: 119 LLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLA-SASYDDTVKLY 177 Query: 189 QGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFD------------G 236 + + T S V + F P SG+ + + DR + + Sbjct: 178 REEEDDW-VCCATLEGHESTVWSLAFDP-SGQRLASCSDDRTVRIWRQYLPGNEQGVACS 235 Query: 237 KSGEFLKYIEDDQEPVQGGIFALSWLDSQ-KFATVGADATIRVW--DVTTSKCVQKWTL- 292 S K I I+ ++W AT D IRV+ D + ++L Sbjct: 236 GSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLT 295 Query: 293 -DKQQLGNQQVGVVA---TGNGRIISLSLDGTLNFYELGHDEVL 332 Q +Q V VA G + S S DG + F++ E L Sbjct: 296 AHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQRPEGL 339 Score = 86.9 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 62/387 (16%), Positives = 130/387 (33%), Gaps = 91/387 (23%) Query: 212 VEFSPDSGEFVITVGSDRKISCFDGKSGEFL---KYIEDDQEPVQGGIFALSWLDSQKFA 268 + ++P +G + + G DR+I + + ++ E Q V+ ++ A Sbjct: 22 LAWNP-AGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPC---GNYLA 77 Query: 269 TVGADATIRVW--DVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYEL 326 + DAT +W + +CV TL+ + + V +GN + + S D ++ +E+ Sbjct: 78 SASFDATTCIWKKNQDDFECV--TTLEGHENEVKSVAWAPSGN-LLATCSRDKSVWVWEV 134 Query: 327 GHD---EVLKTISGHNKGITALTVNP----LISGSYDGRIME-------WSSSSMHQDHS 372 + E + ++ H + + + +P L S SYD + W + + H Sbjct: 135 DEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHE 194 Query: 373 NLIVSLDNSK-AQEYSSISWDDTLKV--NGITKHEFGSQPKVASANNDGFTAVLTNDDDL 429 + + SL Q +S S D T+++ + +E G + + L+ Sbjct: 195 STVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSD-PSWKCICTLSGFHSR 253 Query: 430 LILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRA 489 I + ++ D + + P + Sbjct: 254 TIYDIAWCQLTGALA---------------------------TACGDDAIRVFQEDP-NS 285 Query: 490 KPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEE 549 P + S + A H+ +N ++W P E G Sbjct: 286 DPQQPTFSLTAHLHQA------------------------HSQDVNCVAWNPKEPG---- 317 Query: 550 EIEEDLVATGSLDTNIFIYSVKRPMKI 576 L+A+ S D + + +RP + Sbjct: 318 -----LLASCSDDGEVAFWKYQRPEGL 339 Score = 47.2 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 36/229 (15%), Positives = 77/229 (33%), Gaps = 21/229 (9%) Query: 393 DTLKVNGITKHEFGSQPKVASA-NNDGFTAVLTNDDDLLILQSF------TGDIIKSVRL 445 D+L + G S+ + A D + I + + + + Sbjct: 3 DSLVLLGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQR 62 Query: 446 NSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAA 505 A S NY+A + T K D + ++ +PS +A Sbjct: 63 TVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLAT 122 Query: 506 GDVMGKILLYDLQSREVK--TSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDT 563 + ++++ + S HT + + W P+ ++L+A+ S D Sbjct: 123 CSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPS----------QELLASASYDD 172 Query: 564 NIFIYSVKRPMKIIKA-LNAHKDGVNNLLWETPSTLVSS-GADACIKRW 610 + +Y + + A L H+ V +L ++ ++S D ++ W Sbjct: 173 TVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221 >5WJC-A nrPDB Length = 430 Score = 106 bits (265), Expect = 2e-23, Method: Composition-based stats. Identities = 48/259 (18%), Positives = 89/259 (34%), Gaps = 36/259 (13%) Query: 149 SGNSL--GEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSAS-------D 199 +G +L + GH+ + P T +D + + F++S Sbjct: 169 TGEALPQAVLKGHTAEGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPI 228 Query: 200 RTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSG---EFLKYIEDDQEPVQGGI 256 +H+ V DV+F P + +V D + D + E K I+ + + Sbjct: 229 AKYHRHTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVA 288 Query: 257 FALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLS 316 + AT AD T+ +WD+ + TL+ + + + S S Sbjct: 289 INP--FNDYLLATASADKTVALWDLRNPYQ-RLHTLEGHEDEVYGLEWSPHDEPILASSS 345 Query: 317 LDGTLNFYEL--------------GHDEVLKTISGHNKGITALTVNP-----LISGSYDG 357 D + ++L G E+L GH I+ + P + S + D Sbjct: 346 TDRRVCIWDLEKIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPNERWVVGSLADDN 405 Query: 358 RIMEWSSSSMH--QDHSNL 374 + WS S + +DH + Sbjct: 406 ILQIWSPSRVIWGRDHVQV 424 Score = 68.4 bits (165), Expect = 9e-12, Method: Composition-based stats. Identities = 50/346 (14%), Positives = 109/346 (31%), Gaps = 82/346 (23%) Query: 248 DQEPVQGGIFALSWLDSQKFATVGADATIRVWD------VTTSKCVQKWTLDKQQLGNQQ 301 V + + AT+G ++D +TT + + + L Sbjct: 130 HDGDVNRARYMPQKPEI--IATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFG 187 Query: 302 VGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPLISGSYDGRIME 361 + G + + + D + +++ + S I Sbjct: 188 LCWNPNLPGNLATGAEDQVICLWDVQTQS--------------------FTSSETKVI-- 225 Query: 362 WSSSSMHQDHSNLIVSLDNSKAQE--YSSISWDDTLKVNGITKHEFGSQPKVASANNDGF 419 S + + H++++ + E +S+S D TL+++ + PKV A++ Sbjct: 226 -SPIAKYHRHTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAI 284 Query: 420 TAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEV 479 AV N F ++ + + + L Y + EG+ +V+ L Sbjct: 285 NAVAINP--------FNDYLLATASADKTVALWDLRNPYQRLHTLEGHEDEVYGLE---- 332 Query: 480 SFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQS-------REVKTSR------ 526 +P E +A+ ++ ++DL+ + + Sbjct: 333 ----WSP-----------HDEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDGSPELLFM 377 Query: 527 WAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKR 572 HT++I+ SW P E+ + D + I+S R Sbjct: 378 HGGHTNRISEFSWCPNERWVVGSLAD---------DNILQIWSPSR 414 Score = 58.4 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 29/226 (12%), Positives = 63/226 (27%), Gaps = 27/226 (11%) Query: 25 SYDPTTNAIAYPCGKSAFVRCLDDGDSKV-PPVVQFTGHGSSVVTTVKFSPIKGSQYLCS 83 T C + ++KV P+ ++ H + +V V+F P + L S Sbjct: 196 GNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRH-TDIVNDVQFHPQHEA-LLAS 253 Query: 84 GDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWD-FEGRRLCVVGEGRDNFG 142 + + + + E + Q + I+ ++ + F L + Sbjct: 254 VSDDCTLQIHDTRLNPEEEA-----PKVIQAHSKAINAVAINPFNDYLLATASADK---- 304 Query: 143 VFISWDSGN---SLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPF------ 193 WD N L + GH + + D V + Sbjct: 305 TVALWDLRNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTP 364 Query: 194 -----KFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCF 234 H + + + + P+ V ++ D + + Sbjct: 365 EDAEDGSPELLFMHGGHTNRISEFSWCPNERWVVGSLADDNILQIW 410 Score = 50.3 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 37/212 (17%), Positives = 71/212 (33%), Gaps = 23/212 (10%) Query: 415 NNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSA--------VSLSQNYVAVGLEEG 466 + + T D L ++ ++K G ++ + L + Sbjct: 153 GGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLCWNPNLPGNLATGAEDQVICLWDV 212 Query: 467 NTIQVFKLSDLEVSFDLKTPLRAKP-SYISISPS-ETYIAAGDVMGKILLYD--LQSREV 522 T +S K + + P E +A+ + ++D L E Sbjct: 213 QTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEE 272 Query: 523 KTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNA 582 H+ INA++ P + L+AT S D + ++ ++ P + + L Sbjct: 273 APKVIQAHSKAINAVAINP---------FNDYLLATASADKTVALWDLRNPYQRLHTLEG 323 Query: 583 HKDGVNNLLWE--TPSTLVSSGADACIKRWNV 612 H+D V L W L SS D + W++ Sbjct: 324 HEDEVYGLEWSPHDEPILASSSTDRRVCIWDL 355 >5WLC-LO nrPDB Length = 923 Score = 103 bits (255), Expect = 3e-22, Method: Composition-based stats. Identities = 83/528 (15%), Positives = 164/528 (31%), Gaps = 93/528 (17%) Query: 68 TTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEF-QVLAGPISDISWDF 126 + VKFSP L SG + +W + V+ I+ ++W Sbjct: 100 SAVKFSPDGRLFALASG---RFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQ 156 Query: 127 EGRRLCVVGEGRDNFGVFISWDSGNSLGEVS-----GHSQRINACHLKQSRPMRSMTVGD 181 + R + + W + ++ GH + + + TV Sbjct: 157 DSRFILTTSKDLSA----KIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQ-EKIYTVSK 211 Query: 182 DGSVVFYQGP--------------------PFKFSASDRT----HHKQGSFVRDVEFSPD 217 DG+V ++ + T + + V+ V F P Sbjct: 212 DGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPA 271 Query: 218 SGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGAD-ATI 276 + + + + +D ++ + Q PV + + A + + Sbjct: 272 T-RLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQT---GEWLAFGSSKLGQL 327 Query: 277 RVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNG-RIISLSLDGTLNFYELGHDEVLKTI 335 V++ + + + L +Q + + + +G R+++ S DG + +++ L T Sbjct: 328 LVYEWQS----ESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATF 383 Query: 336 SGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQ-----------------DHSNL 374 H +TA+ + S S DG + W D S Sbjct: 384 EEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGE 443 Query: 375 IVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQS 434 +V + + S ++ ++ HE S + A + D + I Sbjct: 444 VVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFS-QENSVLASASWDKTIRIWSI 502 Query: 435 F-TGDIIKSVRLNSPGSAVSL--SQNYVAVGLEEGNTIQVFKLSDLEV------------ 479 F ++ + + S A+S+ VAV +G I +F + D + Sbjct: 503 FGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQ-ISIFNIEDAKQVGNIDCRKDIIS 561 Query: 480 ------SFDLKTPLRAK-PSYISISPSETYIAAGDVMGKILLYDLQSR 520 F K R+K + I S I AG I LYD+ + Sbjct: 562 GRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNE 609 Score = 94.2 bits (232), Expect = 2e-19, Method: Composition-based stats. Identities = 79/479 (16%), Positives = 163/479 (34%), Gaps = 48/479 (10%) Query: 155 EVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEF 214 + G R VG V + K + H K + ++ Sbjct: 9 NLLGTVYRQGNITFSDDGKQLLSPVG--NRVSVFDLINNKSFTFEYEHRKN---IAAIDL 63 Query: 215 SPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADA 274 + G +I++ D + + K+ L + + +E F+ D + FA Sbjct: 64 NK-QGTLLISIDEDGRAILVNFKARNVLHHF-NFKEKCSAVKFS---PDGRLFALASG-R 117 Query: 275 TIRVW---DVTTSKCVQKWTLDKQQLGNQQ--VGVVATGNGR-IISLSLDGTLNFYELGH 328 +++W DV + + + G+ Q + + + R I++ S D + + + Sbjct: 118 FLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDS 177 Query: 329 DE---VLKTISGHNKGITALTVN----PLISGSYDGRIMEWSSSSM-HQDHSNLIVSLDN 380 +E T +GH + + + + S DG + W + D N D Sbjct: 178 EEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDK 237 Query: 381 SKAQEYSSISWDDTLKVNGITKHEFGSQPKVASA---NNDGFTAVLTNDDDLLILQSFTG 437 + + S SW T K + +Q KV AV + + Sbjct: 238 QEEVDISKYSWRITKK-----HFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDF 292 Query: 438 DIIKSVRL-NSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLR-AKPSYIS 495 +I+ + + +P + VS++Q + Q+ S+ LK + ++ Sbjct: 293 TLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLA 352 Query: 496 ISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDL 555 SP + + GKI ++D+ S + + HTS + A+ + + + Sbjct: 353 YSPDGSRVVTASEDGKIKVWDITSGFC-LATFEEHTSSVTAVQFAKRGQ----------V 401 Query: 556 VATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSGADAC--IKRWNV 612 + + SLD + + + R + N L + +V +G+ I W+V Sbjct: 402 MFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSV 460 >5OQL-d nrPDB Length = 446 Score = 101 bits (252), Expect = 7e-22, Method: Composition-based stats. Identities = 50/326 (15%), Positives = 99/326 (30%), Gaps = 42/326 (12%) Query: 61 GHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPIS 120 GH V + K + SG G V VW T E + Sbjct: 64 GHVQGVYSMCK--DKNSLNCIASGSGDGVVKVWDLTTRDEE-------TWRVAAHNNIVK 114 Query: 121 DISWDFEGRRLCVVGEGRDNFGVFISWD-----SGNSLGEVSGHSQRINACHLKQSRPMR 175 +++ + + L +G WD S + + +S Sbjct: 115 GLTFTNDKKLLSCATDG------IKLWDPYASPSNTTPIATWQEGGPYTSLSFHRSANTF 168 Query: 176 SMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFD 235 + + G + + + + + DV F+ + +V +DR I FD Sbjct: 169 AAS-SGQGCIRIWDLEHSTAGQAIQ-WPSFVDTITDVCFNQVETSVIGSVATDRSIILFD 226 Query: 236 GKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTT-SKCVQKWTLDK 294 ++ + +F +++ A D I ++D K + Sbjct: 227 LRTNMPVIKTVLHFA-CNRIVFNP--MEAMNLAVASEDHNIYIFDARNFDKALNIQKGHV 283 Query: 295 QQLGNQQVGVVATGNGRIISLSLDGTLNFY--ELGHDEVLKTISGHNKGI-------TAL 345 V TG ++S S D T+ + + GH + H K + + Sbjct: 284 A--AVMDVEFSPTGE-ELVSGSYDRTIRLWRRDAGHSRDVY----HTKRMQRVFRTMWTM 336 Query: 346 TVNPLISGSYDGRIMEWSSSSMHQDH 371 +++GS DG + W +++ + Sbjct: 337 DSKYILTGSDDGNVRLWRANASERSG 362 Score = 83.0 bits (203), Expect = 3e-16, Method: Composition-based stats. Identities = 41/268 (15%), Positives = 82/268 (30%), Gaps = 22/268 (8%) Query: 15 STQRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSP 74 + T + C ++ D S T T++ F Sbjct: 105 RVAAHNNIVKGLTFTNDKKLLSCATDG-IKLWDPYASPSNTTPIATWQEGGPYTSLSFHR 163 Query: 75 IKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWD-FEGRRLCV 133 + + G + +W + ++ I+D+ ++ E + Sbjct: 164 SANT--FAASSGQGCIRIW------DLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGS 215 Query: 134 VGEGRDNFGVFISWDSGNSLGEVSG--HSQRINACHLKQSRPMRSMTVGDDGSVVFYQGP 191 V R I +D ++ + H N M +D ++ + Sbjct: 216 VATDRS----IILFDLRTNMPVIKTVLHFAC-NRIVFNPMEAMNLAVASEDHNIYIFDAR 270 Query: 192 PFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEP 251 F + + V DVEFSP +GE +++ DR I + +G + Sbjct: 271 --NFDKALNIQKGHVAAVMDVEFSP-TGEELVSGSYDRTIRLWRRDAGHSRDVY--HTKR 325 Query: 252 VQGGIFALSWLDSQKFATVGADATIRVW 279 +Q + +DS+ T D +R+W Sbjct: 326 MQRVFRTMWTMDSKYILTGSDDGNVRLW 353 Score = 80.0 bits (195), Expect = 3e-15, Method: Composition-based stats. Identities = 53/335 (15%), Positives = 114/335 (34%), Gaps = 50/335 (14%) Query: 246 EDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVV 305 + V + L+ A+ D ++VWD+TT + W + + G+ Sbjct: 63 NGHVQGVYSMCKDKNSLNC--IASGSGDGVVKVWDLTTRDE-ETWRVAAHNNIVK--GLT 117 Query: 306 ATGNGRIISLSLDGTLNFYELGHDEVLKTISG---HNKGITALTVNP----LISGSYDGR 358 T + +++S + DG + ++ T T+L+ + + S G Sbjct: 118 FTNDKKLLSCATDG-IKLWDPYASPSNTTPIATWQEGGPYTSLSFHRSANTFAASSGQGC 176 Query: 359 IMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDG 418 I W L++S A + +I W + V+ IT F Sbjct: 177 IRIWD--------------LEHSTAGQ--AIQW-PSF-VDTITDVCFNQV-------ETS 211 Query: 419 FTAVLTNDDDLLILQSFTGDIIKSVRLNSPG--SAVSLSQNYVAVGLEEGNTIQVFKLSD 476 + D +++ T + L+ + + E + I +F + Sbjct: 212 VIGSVATDRSIILFDLRTNMPVIKTVLHFACNRIVFNPMEAMNLAVASEDHNIYIFDARN 271 Query: 477 LEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINA 536 + + +++ A + SP+ + +G I L+ R+ SR +HT ++ Sbjct: 272 FDKALNIQKGHVAAVMDVEFSPTGEELVSGSYDRTIRLW---RRDAGHSRDVYHTKRMQR 328 Query: 537 ISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVK 571 + ++ + TGS D N+ ++ Sbjct: 329 V-------FRTMWTMDSKYILTGSDDGNVRLWRAN 356 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 21/139 (15%), Positives = 46/139 (33%), Gaps = 14/139 (10%) Query: 70 VKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGR 129 + F+P++ + ++ I FD + +N++ + + D+ + G Sbjct: 245 IVFNPMEAMNLAVASEDHNIYI-----FDARNFDKALNIQ---KGHVAAVMDVEFSPTGE 296 Query: 130 RLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINAC--HLKQSRPMRSMTVGDDGSVVF 187 L R W H++R+ + +T DDG+V Sbjct: 297 ELVSGSYDR----TIRLWRRDAGHSRDVYHTKRMQRVFRTMWTMDSKYILTGSDDGNVRL 352 Query: 188 YQGPPFKFSASDRTHHKQG 206 ++ + S T +Q Sbjct: 353 WRANASERSGVKATRQRQA 371 Score = 33.4 bits (74), Expect = 0.35, Method: Composition-based stats. Identities = 17/83 (20%), Positives = 32/83 (38%), Gaps = 10/83 (12%) Query: 529 FHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVN 588 H + ++ K N +A+GS D + ++ + + + AH + V Sbjct: 64 GHVQGVYSM-----CKDKNSLNC----IASGSGDGVVKVWDLTTRDEETWRVAAHNNIVK 114 Query: 589 NLLWETPSTLVSSGADACIKRWN 611 L + L+S D IK W+ Sbjct: 115 GLTFTNDKKLLSCATDG-IKLWD 136 >5I2T-A nrPDB Length = 742 Score = 101 bits (251), Expect = 1e-21, Method: Composition-based stats. Identities = 83/528 (15%), Positives = 164/528 (31%), Gaps = 93/528 (17%) Query: 68 TTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEF-QVLAGPISDISWDF 126 + VKFSP L SG + +W + V+ I+ ++W Sbjct: 125 SAVKFSPDGRLFALASG---RFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQ 181 Query: 127 EGRRLCVVGEGRDNFGVFISWDSGNSLGEVS-----GHSQRINACHLKQSRPMRSMTVGD 181 + R + + W + ++ GH + + + TV Sbjct: 182 DSRFILTTSKDLSA----KIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQ-EKIYTVSK 236 Query: 182 DGSVVFYQGP--------------------PFKFSASDRT----HHKQGSFVRDVEFSPD 217 DG+V ++ + T + + V+ V F P Sbjct: 237 DGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPA 296 Query: 218 SGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGAD-ATI 276 + + + + +D ++ + Q PV + + A + + Sbjct: 297 T-RLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQT---GEWLAFGSSKLGQL 352 Query: 277 RVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNG-RIISLSLDGTLNFYELGHDEVLKTI 335 V++ + + + L +Q + + + +G R+++ S DG + +++ L T Sbjct: 353 LVYEWQS----ESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATF 408 Query: 336 SGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQ-----------------DHSNL 374 H +TA+ + S S DG + W D S Sbjct: 409 EEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGE 468 Query: 375 IVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQS 434 +V + + S ++ ++ HE S + A + D + I Sbjct: 469 VVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFS-QENSVLASASWDKTIRIWSI 527 Query: 435 F-TGDIIKSVRLNSPGSAVSL--SQNYVAVGLEEGNTIQVFKLSDLEV------------ 479 F ++ + + S A+S+ VAV +G I +F + D + Sbjct: 528 FGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQ-ISIFNIEDAKQVGNIDCRKDIIS 586 Query: 480 ------SFDLKTPLRAK-PSYISISPSETYIAAGDVMGKILLYDLQSR 520 F K R+K + I S I AG I LYD+ + Sbjct: 587 GRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNE 634 Score = 92.3 bits (227), Expect = 5e-19, Method: Composition-based stats. Identities = 79/479 (16%), Positives = 163/479 (34%), Gaps = 48/479 (10%) Query: 155 EVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEF 214 + G R VG V + K + H K + ++ Sbjct: 34 NLLGTVYRQGNITFSDDGKQLLSPVG--NRVSVFDLINNKSFTFEYEHRKN---IAAIDL 88 Query: 215 SPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADA 274 + G +I++ D + + K+ L + + +E F+ D + FA Sbjct: 89 NK-QGTLLISIDEDGRAILVNFKARNVLHHF-NFKEKCSAVKFS---PDGRLFALASG-R 142 Query: 275 TIRVW---DVTTSKCVQKWTLDKQQLGNQQ--VGVVATGNGR-IISLSLDGTLNFYELGH 328 +++W DV + + + G+ Q + + + R I++ S D + + + Sbjct: 143 FLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDS 202 Query: 329 DE---VLKTISGHNKGITALTVN----PLISGSYDGRIMEWSSSSM-HQDHSNLIVSLDN 380 +E T +GH + + + + S DG + W + D N D Sbjct: 203 EEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDK 262 Query: 381 SKAQEYSSISWDDTLKVNGITKHEFGSQPKVASA---NNDGFTAVLTNDDDLLILQSFTG 437 + + S SW T K + +Q KV AV + + Sbjct: 263 QEEVDISKYSWRITKK-----HFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDF 317 Query: 438 DIIKSVRL-NSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLR-AKPSYIS 495 +I+ + + +P + VS++Q + Q+ S+ LK + ++ Sbjct: 318 TLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLA 377 Query: 496 ISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDL 555 SP + + GKI ++D+ S + + HTS + A+ + + + Sbjct: 378 YSPDGSRVVTASEDGKIKVWDITSGFC-LATFEEHTSSVTAVQFAKRGQ----------V 426 Query: 556 VATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSGADAC--IKRWNV 612 + + SLD + + + R + N L + +V +G+ I W+V Sbjct: 427 MFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSV 485 >6BX3-A nrPDB Length = 314 Score = 100 bits (249), Expect = 1e-21, Method: Composition-based stats. Identities = 43/275 (15%), Positives = 94/275 (34%), Gaps = 31/275 (11%) Query: 109 KSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHL 168 ++ A P S++ W +G+ + + F V I S L GH+ + + Sbjct: 47 QTLVTSHARPFSELCWSPDGQCIATASDD---FSVEIIHLSYGLLHTFIGHTAPVISLTF 103 Query: 169 KQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSD 228 + + T D S+ + +T V V+ + + + D Sbjct: 104 NRKGNLL-FTSSMDESIKIWDTLNGSL---MKTISAHSEAVVSVDVPMNDSSILSSGSYD 159 Query: 229 RKISCFDGKSGEFLKYIEDDQE--------PVQGGIFALSWLDSQKFATVGADATIRVWD 280 I FD ++G LK + D++ P+ F+ +++ D +++WD Sbjct: 160 GLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFS---ENARYLLVKSLDGVVKIWD 216 Query: 281 VTTSKCVQKWTLD-------KQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLK 333 V+ + + G + +IS +G + + +L+ Sbjct: 217 CIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQ 276 Query: 334 TISG----HNKGITALTV--NPLISGSYDGRIMEW 362 + G H+ + ++ N + S + +G W Sbjct: 277 LLDGSLYHHSSPVMSIHCFGNIMCSLALNGDCCLW 311 Score = 78.0 bits (190), Expect = 1e-14, Method: Composition-based stats. Identities = 51/288 (17%), Positives = 101/288 (35%), Gaps = 51/288 (17%) Query: 193 FKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYI-EDDQEP 251 F+F T + + + SPD IT G I +D + + P Sbjct: 1 FQFVTPVGTQNGLKAT--CAKISPDGQFLAITQGL--NILIYDINRRTVSQTLVTSHARP 56 Query: 252 VQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGR 311 ++ D Q AT D ++ + ++ + + + GN Sbjct: 57 FSELCWS---PDGQCIATASDDFSVEIIHLSYGL-LHTFIGHTAP--VISLTFNRKGN-L 109 Query: 312 IISLSLDGTLNFYELGHDEVLKTISGHNKGITALTV-----NPLISGSYDGRIMEWSSSS 366 + + S+D ++ ++ + ++KTIS H++ + ++ V + L SGSYDG I + + + Sbjct: 110 LFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAET 169 Query: 367 MH-------------QDHSNLIVSLDNSKAQEYSSIS--------WDD-------TLKVN 398 H ++ I + S+ Y + WD T +V Sbjct: 170 GHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQ 229 Query: 399 GITKHEFGSQPKVASA--NNDGFT-AVLTNDD--DLLILQSFTGDIIK 441 + K DG T V++ + D+ S T +++ Sbjct: 230 PLEKGVLHHSC-GMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQ 276 Score = 57.6 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 45/338 (13%), Positives = 110/338 (32%), Gaps = 41/338 (12%) Query: 288 QKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTI-SGHNKGITALT 346 Q T Q G + + +G+ ++++ + Y++ V +T+ + H + + L Sbjct: 2 QFVTPVGTQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELC 61 Query: 347 VNP----LISGSYDGRIME----WSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVN 398 +P + + S D + + H+ ++SL ++ S Sbjct: 62 WSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTS-------- 113 Query: 399 GITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNY 458 K+ N ++ + ++ V +N S +S Sbjct: 114 -----SMDESIKIWDTLNGSLMKTISAHSEAVV--------SVDVPMNDS-SILSSGSYD 159 Query: 459 VAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQ 518 + + + T K + + + + S + S + Y+ + G + ++D Sbjct: 160 GLIRIFDAETGHCLKTLTYDKDWKRENGV-VPISQVKFSENARYLLVKSLDGVVKIWDCI 218 Query: 519 SREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIK 578 V + + + N E+ LV +G + +I+ ++ + Sbjct: 219 GGCV-VRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQL 277 Query: 579 ---ALNAHKDGVNNLLWETPSTLVSS---GADACIKRW 610 +L H V ++ ++ S D C+ RW Sbjct: 278 LDGSLYHHSSPVMSI--HCFGNIMCSLALNGDCCLWRW 313 Score = 48.0 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 27/188 (14%), Positives = 60/188 (31%), Gaps = 21/188 (11%) Query: 59 FTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGP 118 + H +VV+ P+ S L SG G + ++ ++ + + + P Sbjct: 133 ISAHSEAVVSVDV--PMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVP 190 Query: 119 ISDISWDFEGRRLCVVGEGRDNFGVFISWDS-GNSL----------GEVSGHSQRINACH 167 IS + + R L V GV WD G + V HS ++ + Sbjct: 191 ISQVKFSENARYLLVKSLD----GVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLN 246 Query: 168 LKQSRPMRSMTVGDDGSVVFYQGPPFKFSASD-RTHHKQGSFVRDVEFSPDSGEFVITVG 226 + ++ ++G + + + + S V + G + ++ Sbjct: 247 PEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHC---FGNIMCSLA 303 Query: 227 SDRKISCF 234 + + Sbjct: 304 LNGDCCLW 311 Score = 43.8 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 30/155 (19%), Positives = 60/155 (38%), Gaps = 35/155 (22%) Query: 490 KPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEE 549 K + ISP ++A + IL+YD+ R V + H + + W P + Sbjct: 14 KATCAKISPDGQFLAITQGLN-ILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATA 72 Query: 550 EIE-------------------------------EDLVATGSLDTNIFIYSVKRPMKIIK 578 + +L+ T S+D +I I+ ++K Sbjct: 73 SDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGS-LMK 131 Query: 579 ALNAHKDGVNNLLW-ETPSTLVSSGA-DACIKRWN 611 ++AH + V ++ S+++SSG+ D I+ ++ Sbjct: 132 TISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFD 166 >5OQL-J nrPDB Length = 912 Score = 99 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 83/666 (12%), Positives = 194/666 (29%), Gaps = 131/666 (19%) Query: 24 LSYDPTTNAIAYPCGKSAFVRCLD-----DGDSKVPPVVQFTGHGSSVVTTVKFSPIKGS 78 L+ P+ + + C +S +R D DS P +V+ T V + + S Sbjct: 67 LTITPSGSHL-IVCSRSLTMRIYSLAISPDYDSVEPTLVRTT--KPHATPVVVLAVDRTS 123 Query: 79 QYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVG--- 135 L +G G + +W +++V + I+ + + G Sbjct: 124 TLLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHFFEIAVTAESQSSNKKPKKGSRK 183 Query: 136 ---EGRDNFGVFISWDSGNSLGEV---------------------SGHSQRINACHLKQS 171 + D G G + H + Sbjct: 184 GQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPE 243 Query: 172 RPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKI 231 + ++ D ++ + ++ T + + V F + G+++ + G+ + Sbjct: 244 Q-HALLSGSRDKTMTLW---LWRDGIWQGTPMLRHELLESVGFLNE-GKWMYSAGTSGVL 298 Query: 232 SCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCV---- 287 +D + + +D + + + A+S + AD T+ ++ V + V Sbjct: 299 RIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILCAQADFTLVLYRVPSPADVVSSS 358 Query: 288 ------QKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGH------------- 328 + + + + + + + Sbjct: 359 EGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRS 418 Query: 329 ----DEVLKTISGHNKGITALTV----NPLISGSYDGRIMEWSSSSMHQDHSNLIVSLDN 380 + + GH + +L V + + SGS D W + ++ ++ Sbjct: 419 GSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYT--CYAVFT 476 Query: 381 SKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDII 440 + +++ PKV N + ++ + Sbjct: 477 GHLESVGAVAL-----------------PKVVPPANSEAFKNPLDHPPAFLISGSQDRFV 519 Query: 441 KSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAK-PSYISISPS 499 + + L++G + + L+ K + + ISP+ Sbjct: 520 QKRDIPRQ--------------LQKGGKL----------TSSLRRLAHDKDINALDISPN 555 Query: 500 ETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEED----L 555 A+ + ++D++ EV+ H + + + P + E + Sbjct: 556 GKLFASASQDKTVKIWDVEKLEVQ-GILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGV 614 Query: 556 VATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWE----------TPSTLVSSGADA 605 V TGS D I ++++ I+ H V ++W T S+GAD Sbjct: 615 VLTGSGDKTIKLWNLSD-YTCIRTFEGHSHNVLKVVWLHISRDDSITKTKVQFASAGADT 673 Query: 606 CIKRWN 611 +K W+ Sbjct: 674 LVKVWD 679 Score = 90.4 bits (222), Expect = 2e-18, Method: Composition-based stats. Identities = 67/450 (14%), Positives = 131/450 (29%), Gaps = 88/450 (19%) Query: 75 IKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVV 134 + +++ S SG + +W T E + +L+ +S LC Sbjct: 283 LNEGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSA----VSLPERSLILCAQ 338 Query: 135 GEGR------DNFGVFISWDSG---NSLGEVSG-HSQRINACHLKQSRPMRSM-TVGDD- 182 + + +S G +SG H + ++ ++ + M ++ T +D Sbjct: 339 ADFTLVLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDI 398 Query: 183 GSVVFYQGPPFK-----------FSASDRTHHKQGSFV--RDVEFSPDSGEFVITVGSDR 229 V + F V DV++S G ++ + D Sbjct: 399 RIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWS---GHWIASGSKDN 455 Query: 230 KISCF--DGKSGE--FLKYIEDDQEPVQGGIF-------------ALSWLDSQKFATVGA 272 + D + E V + Sbjct: 456 TARLWRVDPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLDHPPAFLISGSQ 515 Query: 273 DATIRVWDVTT-----SKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELG 327 D ++ D+ K + + G S S D T+ +++ Sbjct: 516 DRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPNG-KLFASASQDKTVKIWDVE 574 Query: 328 HDEVLKTISGHNKGITALTVNPL------------------ISGSYDGRIMEWSSSS--- 366 EV + GH +G+ + PL ++GS D I W+ S Sbjct: 575 KLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTC 634 Query: 367 --MHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGI--TKHEFGSQPKVASANNDGFTAV 422 + HS+ ++ + + IS DD++ + + KV AN Sbjct: 635 IRTFEGHSHNVLKVV------WLHISRDDSITKTKVQFASAGADTLVKVWDANTGETECT 688 Query: 423 LTNDDDLL--ILQSFTGDIIKSVRLNSPGS 450 L N +D L + +I+ S +S + Sbjct: 689 LDNHEDRLWTLAVHSKTNILASAGSDSKVT 718 Score = 72.3 bits (175), Expect = 7e-13, Method: Composition-based stats. Identities = 41/270 (15%), Positives = 80/270 (29%), Gaps = 47/270 (17%) Query: 46 LDDGDSKVPPVVQFTGHGSSV--VTTVKFSPIKGSQ-----------YLCSGDESGKVIV 92 +D ++ FTGH SV V K P S+ +L SG + V Sbjct: 462 VDPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQK 521 Query: 93 WGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWD--SG 150 + + I+ + G+ + + WD Sbjct: 522 RDIPRQLQKGGKLTSSLRRLA-HDKDINALDISPNGKLFASASQDK----TVKIWDVEKL 576 Query: 151 NSLGEVSGHSQRINACHLKQ-------------SRPMRSMTVGDDGSVVFYQGPPFKFSA 197 G + GH + + S +T D ++ + + Sbjct: 577 EVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTC-- 634 Query: 198 SDRTHHKQGSFVRDVEF---SPDSGE-----FVITVGSDRKISCFDGKSGEFLKYIEDDQ 249 RT V V + S D + G+D + +D +GE +++ + Sbjct: 635 -IRTFEGHSHNVLKVVWLHISRDDSITKTKVQFASAGADTLVKVWDANTGETECTLDNHE 693 Query: 250 EPVQGGIFALSWLDSQKFATVGADATIRVW 279 + + A+ + A+ G+D+ + W Sbjct: 694 DRL--WTLAVHSKTN-ILASAGSDSKVTFW 720 Score = 69.2 bits (167), Expect = 5e-12, Method: Composition-based stats. Identities = 74/529 (13%), Positives = 150/529 (28%), Gaps = 114/529 (21%) Query: 194 KFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCF--------DGKSGEFLKYI 245 G + + +P SG +I + + D ++ Sbjct: 49 NTGKRLAEIQGDGEPISTLTITP-SGSHLIVCSRSLTMRIYSLAISPDYDSVEPTLVRTT 107 Query: 246 EDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTL--------DKQQL 297 + PV + A+ S AT AD I++WD+ + ++ Sbjct: 108 KPHATPV--VVLAV-DRTSTLLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHFFEI 164 Query: 298 GNQQVGVVATGNG-------------------RIISLSLDGTLNFYELGHDEV------- 331 + R+ + DG + ++L Sbjct: 165 AVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADP 224 Query: 332 LKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYS 387 + H + + +P L+SGS D + W + ++ + Sbjct: 225 KRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDGIWQGTPMLRHELLESVGFLN 284 Query: 388 SISWDDTLKVNGI-------TKHEFGSQPKVASANNDGFTAVLTNDDDLLI--------- 431 W + +G+ T HE + S +AV + L++ Sbjct: 285 EGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILCAQADFTLV 344 Query: 432 ----------LQSFTGDIIKSVRLNSPGSAVSLSQNYVA------VGLEEGNTIQVFKLS 475 + S G +++ R S L Y+ I++ + Sbjct: 345 LYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVSVK 404 Query: 476 DLEVSFDLKTPLRAK----------------PSYISISPSETYIAAGDVMGKILLYDL-- 517 D + + R+ + + S +IA+G L+ + Sbjct: 405 DAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDP 464 Query: 518 -QSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDL------VATGSLDTNIFIYSV 570 + + + H + A++ AN E + L + +GS D + + Sbjct: 465 ANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDI 524 Query: 571 KRPM----KIIKALN--AHKDGVNNLLWETPSTL-VSSGADACIKRWNV 612 R + K+ +L AH +N L L S+ D +K W+V Sbjct: 525 PRQLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQDKTVKIWDV 573 Score = 53.4 bits (126), Expect = 3e-07, Method: Composition-based stats. Identities = 44/350 (12%), Positives = 104/350 (29%), Gaps = 39/350 (11%) Query: 258 ALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSL 317 +++ + + + ++ T K + + D + + + + +G+ I+ S Sbjct: 25 SVALENGARILASTLGENAILTELNTGKRLAEIQGDGEPIS--TLTITPSGSHLIV-CSR 81 Query: 318 DGTLNFYELG--------HDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSS 365 T+ Y L +++T H + L V+ L +G+ DG I W Sbjct: 82 SLTMRIYSLAISPDYDSVEPTLVRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDII 141 Query: 366 SMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGF---TAV 422 + H+ S+ S + ++ N K + + A+ A Sbjct: 142 GGYVTHTVSGPSVLVSALHFFEIAVTAESQSSNKKPKKG-SRKGQNDDADEIASRFRLAW 200 Query: 423 LTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFD 482 T D + I + V + + N + + D ++ Sbjct: 201 GTQDGRIRIFDLYK-RTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLW 259 Query: 483 LK-------TPL--RAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSK 533 L TP+ + ++ + G + ++D H Sbjct: 260 LWRDGIWQGTPMLRHELLESVGFLNEGKWMYSAGTSGVLRIWD---------TTTHHEIT 310 Query: 534 INAISWKPAEKGANEEEIEEDLVATGSL-DTNIFIYSVKRPMKIIKALNA 582 + E + + E + + D + +Y V P ++ + Sbjct: 311 KKQDAKSEGEAILSAVSLPERSLILCAQADFTLVLYRVPSPADVVSSSEG 360 Score = 49.5 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 68/445 (15%), Positives = 143/445 (32%), Gaps = 92/445 (20%) Query: 213 EFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGA 272 + ++G ++ + +G+ L I+ D EP+ S Sbjct: 25 SVALENGARILASTLGENAILTELNTGKRLAEIQGDGEPISTLTITPS---GSHLIVCSR 81 Query: 273 DATIRVW------DVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYEL 326 T+R++ D + + T + V T + + + + DG + +++ Sbjct: 82 SLTMRIYSLAISPDYDSVEPTLVRTTKPHATPVVVLAVDRT-STLLATGAADGAIKIWDI 140 Query: 327 GHDEVLKTISGHNKGITALTV----------------------------NPLIS------ 352 V T+SG + ++AL + + S Sbjct: 141 IGGYVTHTVSGPSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAW 200 Query: 353 GSYDGRIMEWSSSS------------MHQDHSNLIVSLDNSKAQE-YSSISWDDTLKV-- 397 G+ DGRI + + H + + + S Q S S D T+ + Sbjct: 201 GTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLWL 260 Query: 398 --NGITKHEFGSQPKVASA----NNDGFTAVLTNDDDLLILQSFT-GDIIKSVRLNSPG- 449 +GI + + ++ + N + L I + T +I K S G Sbjct: 261 WRDGIWQGTPMLRHELLESVGFLNEGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGE 320 Query: 450 ---SAVSLSQNYVAVGLEEGNTIQVFKL-SDLEVSFDLKTPLRAKPSYIS---------- 495 SAVSL + + + + T+ ++++ S +V + L IS Sbjct: 321 AILSAVSLPERSLILCAQADFTLVLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLT 380 Query: 496 -ISPSETYIAAGDVMGKILL--------YDLQSREVKTSRWAFHTSKINAISWKPAEKGA 546 I P ++ +A I + Y + E ++ + H + + + Sbjct: 381 YILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGH--DVALLKGHEDIVMS 438 Query: 547 NEEEIEEDLVATGSLDTNIFIYSVK 571 + + +A+GS D ++ V Sbjct: 439 LDVDWSGHWIASGSKDNTARLWRVD 463 >5CXC-A nrPDB Length = 510 Score = 99.2 bits (245), Expect = 5e-21, Method: Composition-based stats. Identities = 51/310 (16%), Positives = 94/310 (30%), Gaps = 45/310 (14%) Query: 77 GSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGE 136 G + + S G + +W + + S I + RL G Sbjct: 157 GQERVLSASYDGLLRIWNASGSVIATSPSG----SHGGHTASIKAAKFLT-SDRLASAGM 211 Query: 137 GRDNFGVFISWDSGNS---------LGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVF 187 R W S E+ GH+ ++ + +T DG++ F Sbjct: 212 DR----TVRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVD-GHSKHILTASADGAIGF 266 Query: 188 YQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIED 247 + D + G+ V + S ++ + + Sbjct: 267 WSASKASAPEPDASLL-PGAHVSKRRKATSS----VSTAQRGPLGLWSI----------- 310 Query: 248 DQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVAT 307 P IF D + D T+R D+TT + V TL L + T Sbjct: 311 HTAPATAAIFDP--RDRTVAYSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGT 368 Query: 308 GNGRIISLSLDGTLNFYELGHDEV---LKTISGHNKGITALTVNP-----LISGSYDGRI 359 + + + + + + + T+ GH + +L+ +P L+SGS+DG Sbjct: 369 TSPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTC 428 Query: 360 MEWSSSSMHQ 369 W S+ Sbjct: 429 RVWDLRSVRP 438 Score = 62.2 bits (149), Expect = 7e-10, Method: Composition-based stats. Identities = 61/313 (19%), Positives = 109/313 (34%), Gaps = 49/313 (15%) Query: 220 EFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVW 279 E V++ D + ++ I A +L S + A+ G D T+RVW Sbjct: 159 ERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSDRLASAGMDRTVRVW 218 Query: 280 DVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHN 339 T S +T + + T + S+D + + GH+ Sbjct: 219 KYTES---DHFTGE----------LKPTLELYGHTGSVD-----W--------LDVDGHS 252 Query: 340 KGITALTVNPLISGSYDGRIMEWSSSSMHQDHSN--LIVSLDNSKAQEYSSISWDDTLKV 397 K I ++ S DG I WS+S + L+ SK ++ + S T + Sbjct: 253 KHI--------LTASADGAIGFWSASKASAPEPDASLLPGAHVSKRRK--ATSSVSTAQR 302 Query: 398 NGITKHEFGSQPKVASA--NNDGFTAVLTNDDDLL-ILQSFTGDIIKSVRLNSPGSAVSL 454 + + P A+ D A + D + L TG ++ ++ L P ++S Sbjct: 303 GPLGLWSIHTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSA 362 Query: 455 SQNY------VAVGLEEGNTIQVFKLSDLEVSFDLKTPLRA-KPSYISISPSETY-IAAG 506 +A G + V + + + A K +S SP Y + +G Sbjct: 363 LTRAGTTSPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSG 422 Query: 507 DVMGKILLYDLQS 519 G ++DL+S Sbjct: 423 SHDGTCRVWDLRS 435 Score = 61.1 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 62/344 (18%), Positives = 108/344 (31%), Gaps = 50/344 (14%) Query: 305 VATGNGRIISLSLDGTLNFYELGHDEVLKT-----ISGHNKGITALTV---NPLISGSYD 356 V G R++S S DG L + V+ T GH I A + L S D Sbjct: 154 VQPGQERVLSASYDGLLRIWN-ASGSVIATSPSGSHGGHTASIKAAKFLTSDRLASAGMD 212 Query: 357 GRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANN 416 + W S+ + Y D L V+G +KH + A Sbjct: 213 RTVRVW-----KYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASADGAIGFW 267 Query: 417 DGFTAVLTNDDDLLILQSFTGDIIKSVR-----------------LNSPGSAVSLSQNYV 459 A D L+ + K+ + + V Sbjct: 268 SASKASAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTV 327 Query: 460 AVGLEEGNTIQVFKLSDLEV--SFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDL 517 A + +T++ L+ +V + L PL + + + +AAG I + D Sbjct: 328 AYSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDP 387 Query: 518 QSREVKTS--RWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMK 575 ++ TS H +K+ ++S P E + +GS D ++ ++ Sbjct: 388 RASSATTSVMTLRGHANKVVSLSPSPE---------NEYSLVSGSHDGTCRVWDLRSVRP 438 Query: 576 IIK---ALNAHKDGVNNLL---WETPSTLVSSGADACIKRWNVV 613 K +L + V + W + A K ++VV Sbjct: 439 ATKEEGSLGGVSEPVYVIERESWASKGKKKRPVAGDGCKVFSVV 482 Score = 47.6 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 28/229 (12%), Positives = 66/229 (28%), Gaps = 28/229 (12%) Query: 55 PVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGW-TFDKESNSVEVNVKSEFQ 113 P ++ GH SV S+++ + G + W + + Sbjct: 232 PTLELYGHTGSVD---WLDVDGHSKHILTASADGAIGFWSASKASAPEPDASLLPGAHVS 288 Query: 114 VLAGPISDIS---------WDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRIN 164 S +S W + V S +++ + + ++ Sbjct: 289 KRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVV 348 Query: 165 ACHLKQSRPMRSMTV---GDDGSVVFYQGPPFK-----------FSASDRTHHKQGSFVR 210 + L + P+ S++ S + G + + S T + V Sbjct: 349 S-TLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVV 407 Query: 211 DVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFAL 259 + SP++ +++ D +D +S E V ++ + Sbjct: 408 SLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKEEGSLGGVSEPVYVI 456 Score = 36.4 bits (82), Expect = 0.037, Method: Composition-based stats. Identities = 28/105 (26%), Positives = 41/105 (39%), Gaps = 14/105 (13%) Query: 50 DSKVPPVVQFTGHGSSVVTTVKFSPIKGSQY-LCSGDESGKVIVWGWTFDKESNSVEVNV 108 S V+ GH + VV+ SP ++Y L SG G VW D S Sbjct: 390 SSATTSVMTLRGHANKVVS---LSPSPENEYSLVSGSHDGTCRVW----DLRSVRPATKE 442 Query: 109 KSEFQVLAGPISDI---SWDFEGRRLCVVGEGRDNFGVF-ISWDS 149 + ++ P+ I SW +G++ V D VF + WD Sbjct: 443 EGSLGGVSEPVYVIERESWASKGKKKRPVAG--DGCKVFSVVWDK 485 Score = 29.9 bits (65), Expect = 3.5, Method: Composition-based stats. Identities = 14/77 (18%), Positives = 28/77 (36%), Gaps = 7/77 (9%) Query: 539 WKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALN-----AHKDGVNNLLWE 593 W A + + ++ V + S D + I++ +I H + + Sbjct: 144 WSSAANSSAAVQPGQERVLSASYDGLLRIWNAS--GSVIATSPSGSHGGHTASIKAAKFL 201 Query: 594 TPSTLVSSGADACIKRW 610 T L S+G D ++ W Sbjct: 202 TSDRLASAGMDRTVRVW 218 >6EOJ-D nrPDB Length = 470 Score = 98.5 bits (243), Expect = 7e-21, Method: Composition-based stats. Identities = 40/267 (14%), Positives = 79/267 (29%), Gaps = 19/267 (7%) Query: 58 QFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAG 117 H S+V T S ++ SGD G + +W F VK Sbjct: 130 LMQAHDSAVTT---MKYSHDSDWMISGDADGMIKIWQPNFSM--------VKEIDAAHTE 178 Query: 118 PISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSM 177 I D+++ + + DN ++ +G +SGH + +C Sbjct: 179 SIRDMAFSSNDSKFVTCSD--DNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMG-LIA 235 Query: 178 TVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGK 237 + D V + +S V F P G ++ + D+ FD + Sbjct: 236 SASKDNLVKLWDPRSGNCISSILKFK---HTVLKTRFQPTKGNLLMAISKDKSCRVFDIR 292 Query: 238 SGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQL 297 D+ + ++ F D +++ +D+ + T+ Sbjct: 293 YSMKELMCVRDETDYMTLEWHP--INESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHD 350 Query: 298 GNQQVGVVATGNGRIISLSLDGTLNFY 324 + + D T+ F+ Sbjct: 351 KCITSLSYNPVGHIFATAAKDRTIRFW 377 Score = 91.5 bits (225), Expect = 9e-19, Method: Composition-based stats. Identities = 48/309 (15%), Positives = 105/309 (33%), Gaps = 36/309 (11%) Query: 203 HKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWL 262 +K + ++++P+ G ++ + S ++ S F ++ V ++ Sbjct: 90 NKVKHVIPAIQWTPE-GRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYS---H 145 Query: 263 DSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLN 322 DS + AD I++W + + K + + + + + ++ S D L Sbjct: 146 DSDWMISGDADGMIKIWQP--NFSMVKEIDAAHTESIRDMAFSSNDS-KFVTCSDDNILK 202 Query: 323 FYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSM-------HQDH 371 + + + + +SGH+ + + +P + S S D + W S H Sbjct: 203 IWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKH 262 Query: 372 SNLIVSLDNSKAQEYSSISWDDTLKVNGI---------TKHEFGSQPKVASANNDGFTAV 422 + L +K +IS D + +V I + E N+ Sbjct: 263 TVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINES-MFT 321 Query: 423 LTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFD 482 L D D+++ LN P + + + L +F + + + Sbjct: 322 LACYDG----SLKHFDLLQ--NLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIR 375 Query: 483 LKTPLRAKP 491 T RA+P Sbjct: 376 FWT--RARP 382 Score = 66.1 bits (159), Expect = 4e-11, Method: Composition-based stats. Identities = 26/230 (11%), Positives = 62/230 (26%), Gaps = 17/230 (7%) Query: 52 KVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSE 111 + + + + + + + + +W ++ K+ + Sbjct: 163 QPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQ--------ERV 214 Query: 112 FQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWD--SGNSLGEVSGHSQRINACHLK 169 + W E + + + WD SGN + + + + Sbjct: 215 LSGHHWDVKSCDWHPEMGLIASASKD----NLVKLWDPRSGNCISSILKFKHTVLKTRFQ 270 Query: 170 QSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDR 229 ++ M + D S + ++S + + + +E+ P + D Sbjct: 271 PTKGNLLMAISKDKSCRVFD---IRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDG 327 Query: 230 KISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVW 279 + FD + + FAT D TIR W Sbjct: 328 SLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 Score = 49.2 bits (115), Expect = 6e-06, Method: Composition-based stats. Identities = 25/146 (17%), Positives = 52/146 (35%), Gaps = 14/146 (9%) Query: 468 TIQVFKLSDLEVSFDLKTPLR-AKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSR 526 + + + +F+ + + + S ++ +GD G I ++ VK Sbjct: 114 SGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEID 173 Query: 527 WAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDG 586 A HT I +++ + T S D + I++ K + L+ H Sbjct: 174 -AAHTESIRDMAFSS----------NDSKFVTCSDDNILKIWNFSN-GKQERVLSGHHWD 221 Query: 587 VNNLLWETP-STLVSSGADACIKRWN 611 V + W + S+ D +K W+ Sbjct: 222 VKSCDWHPEMGLIASASKDNLVKLWD 247 Score = 40.3 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 22/128 (17%), Positives = 44/128 (34%), Gaps = 13/128 (10%) Query: 485 TPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEK 544 ++ I +P + G+ L++ S +T H S + + + Sbjct: 90 NKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFET-LMQAHDSAVTTMKYS---- 144 Query: 545 GANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLW-ETPSTLVSSGA 603 + D + +G D I I+ M AH + + ++ + S V+ Sbjct: 145 ------HDSDWMISGDADGMIKIWQPNFSMVKEIDA-AHTESIRDMAFSSNDSKFVTCSD 197 Query: 604 DACIKRWN 611 D +K WN Sbjct: 198 DNILKIWN 205 >5G04-R nrPDB Length = 499 Score = 96.1 bits (237), Expect = 3e-20, Method: Composition-based stats. Identities = 49/303 (16%), Positives = 101/303 (33%), Gaps = 36/303 (11%) Query: 73 SPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLC 132 G+ + V +W + S + ++ E IS ++W EG L Sbjct: 191 DWSSGNVLAVA--LDNSVYLWSAS----SGDILQLLQMEQPGEY--ISSVAWIKEGNYLA 242 Query: 133 VVGEGRDNFGVFISWD--SGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQG 190 V WD L ++ HS R+ + + G + + Sbjct: 243 VGTSS----AEVQLWDVQQQKRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHDV 295 Query: 191 PPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGE----FLKYIE 246 + + T V + ++PD G + + G+D ++ + GE L+ Sbjct: 296 RVAEHHVA--TLSGHSQEVCGLRWAPD-GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFT 352 Query: 247 DDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVA 306 Q V+ + + +D IR+W+V + C+ Q ++ Sbjct: 353 QHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-----QVCSILW 407 Query: 307 TGN-GRIISLS--LDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRI 359 + + +IS L ++ + + GH + +LT++P + S + D + Sbjct: 408 SPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETL 467 Query: 360 MEW 362 W Sbjct: 468 RLW 470 Score = 74.2 bits (180), Expect = 2e-13, Method: Composition-based stats. Identities = 65/377 (17%), Positives = 143/377 (37%), Gaps = 50/377 (13%) Query: 149 SGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSF 208 SG G+ R+ + +++ P + + P + D + + Sbjct: 134 SGKPQNAPEGYQNRLKVLYSQKATP-----GSSRKTCRYIPSLPDRIL--DAPEIRNDYY 186 Query: 209 VRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWL-DSQKF 267 + V++S + V+ V D + + SG+ L+ ++ +Q I +++W+ + Sbjct: 187 LNLVDWSSGN---VLAVALDNSVYLWSASSGDILQLLQMEQPGEY--ISSVAWIKEGNYL 241 Query: 268 ATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIIS-LSLDGTLNFYEL 326 A + A +++WDV K ++ T ++G + N I+S S G ++ +++ Sbjct: 242 AVGTSSAEVQLWDVQQQKRLRNMTSHSARVG------SLSWNSYILSSGSRSGHIHHHDV 295 Query: 327 GHDEV-LKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQDHSNLIVSLDNS 381 E + T+SGH++ + L P L SG D + W S+ L Sbjct: 296 RVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQT--FTQ 353 Query: 382 KAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIK 441 +++W Q V + T+D + I +G + Sbjct: 354 HQGAVKAVAWCP-------------WQSNVLATGGG------TSDRHIRIWNVCSGACLS 394 Query: 442 SVRLNSPGSAVSLSQNYVAVGLEEG---NTIQVFKLSDLEVSFDLKTPLRAKPSYISISP 498 +V +S ++ S +Y + G N + ++K + +LK ++ +++SP Sbjct: 395 AVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHT-SRVLSLTMSP 453 Query: 499 SETYIAAGDVMGKILLY 515 +A+ + L+ Sbjct: 454 DGATVASAAADETLRLW 470 Score = 62.6 bits (150), Expect = 5e-10, Method: Composition-based stats. Identities = 38/183 (20%), Positives = 60/183 (32%), Gaps = 18/183 (9%) Query: 56 VVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVL 115 V +GH V ++L SG V VW V ++ F Sbjct: 302 VATLSGHSQEV---CGLRWAPDGRHLASGGNDNLVNVWPSAP---GEGGWVPLQ-TFTQH 354 Query: 116 AGPISDISW-DFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPM 174 G + ++W ++ L G D + SG L V HSQ C + S Sbjct: 355 QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ---VCSILWSPHY 411 Query: 175 RSMTVGD---DGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKI 231 + + G +V ++ P A S V + SPD G V + +D + Sbjct: 412 KELISGHGFAQNQLVIWKYPTM---AKVAELKGHTSRVLSLTMSPD-GATVASAAADETL 467 Query: 232 SCF 234 + Sbjct: 468 RLW 470 Score = 50.3 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 40/210 (19%), Positives = 88/210 (41%), Gaps = 28/210 (13%) Query: 416 NDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSL-----SQNYVAVGLEEGNTIQ 470 + G + D+ + + + +GDI++ +++ PG +S NY+AVG Sbjct: 193 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAE--- 249 Query: 471 VFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFH 530 +L D++ L+ S+S + +++G G I +D++ E + + H Sbjct: 250 -VQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGH 308 Query: 531 TSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMK----IIKALNAHKDG 586 + ++ + W P + +A+G D + ++ P + ++ H+ Sbjct: 309 SQEVCGLRWAPDGRH----------LASGGNDNLVNVWP-SAPGEGGWVPLQTFTQHQGA 357 Query: 587 VNNLLWET-PSTLVSSGA---DACIKRWNV 612 V + W S ++++G D I+ WNV Sbjct: 358 VKAVAWCPWQSNVLATGGGTSDRHIRIWNV 387 Score = 46.1 bits (107), Expect = 5e-05, Method: Composition-based stats. Identities = 19/140 (13%), Positives = 43/140 (30%), Gaps = 10/140 (7%) Query: 49 GDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNV 108 G+ P+ FT H +V G + +W ++V+ + Sbjct: 341 GEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS 400 Query: 109 KSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHL 168 + + I W + L N V + + + E+ GH+ R+ + + Sbjct: 401 Q---------VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTM 451 Query: 169 KQSRPMRSMTVGDDGSVVFY 188 + D ++ + Sbjct: 452 SPDG-ATVASAAADETLRLW 470 >4GGA-A nrPDB Length = 420 Score = 95.8 bits (236), Expect = 5e-20, Method: Composition-based stats. Identities = 49/303 (16%), Positives = 101/303 (33%), Gaps = 36/303 (11%) Query: 73 SPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLC 132 G+ + V +W + S + ++ E IS ++W EG L Sbjct: 112 DWSSGNVLAVA--LDNSVYLWSAS----SGDILQLLQMEQPGEY--ISSVAWIKEGNYLA 163 Query: 133 VVGEGRDNFGVFISWD--SGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQG 190 V WD L ++ HS R+ + + G + + Sbjct: 164 VGTSS----AEVQLWDVQQQKRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHDV 216 Query: 191 PPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGE----FLKYIE 246 + + T V + ++PD G + + G+D ++ + GE L+ Sbjct: 217 RVAEHHVA--TLSGHSQEVCGLRWAPD-GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFT 273 Query: 247 DDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVA 306 Q V+ + + +D IR+W+V + C+ Q ++ Sbjct: 274 QHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-----QVCSILW 328 Query: 307 TGN-GRIISLS--LDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRI 359 + + +IS L ++ + + GH + +LT++P + S + D + Sbjct: 329 SPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETL 388 Query: 360 MEW 362 W Sbjct: 389 RLW 391 Score = 73.4 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 65/377 (17%), Positives = 143/377 (37%), Gaps = 50/377 (13%) Query: 149 SGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSF 208 SG G+ R+ + +++ P + + P + D + + Sbjct: 55 SGKPQNAPEGYQNRLKVLYSQKATP-----GSSRKTCRYIPSLPDRIL--DAPEIRNDYY 107 Query: 209 VRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWL-DSQKF 267 + V++S + V+ V D + + SG+ L+ ++ +Q I +++W+ + Sbjct: 108 LNLVDWSSGN---VLAVALDNSVYLWSASSGDILQLLQMEQPGEY--ISSVAWIKEGNYL 162 Query: 268 ATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIIS-LSLDGTLNFYEL 326 A + A +++WDV K ++ T ++G + N I+S S G ++ +++ Sbjct: 163 AVGTSSAEVQLWDVQQQKRLRNMTSHSARVG------SLSWNSYILSSGSRSGHIHHHDV 216 Query: 327 GHDEV-LKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQDHSNLIVSLDNS 381 E + T+SGH++ + L P L SG D + W S+ L Sbjct: 217 RVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQT--FTQ 274 Query: 382 KAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIK 441 +++W Q V + T+D + I +G + Sbjct: 275 HQGAVKAVAWCPW-------------QSNVLATGGG------TSDRHIRIWNVCSGACLS 315 Query: 442 SVRLNSPGSAVSLSQNYVAVGLEEG---NTIQVFKLSDLEVSFDLKTPLRAKPSYISISP 498 +V +S ++ S +Y + G N + ++K + +LK ++ +++SP Sbjct: 316 AVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHT-SRVLSLTMSP 374 Query: 499 SETYIAAGDVMGKILLY 515 +A+ + L+ Sbjct: 375 DGATVASAAADETLRLW 391 Score = 62.2 bits (149), Expect = 7e-10, Method: Composition-based stats. Identities = 38/183 (20%), Positives = 60/183 (32%), Gaps = 18/183 (9%) Query: 56 VVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVL 115 V +GH V ++L SG V VW V ++ F Sbjct: 223 VATLSGHSQEV---CGLRWAPDGRHLASGGNDNLVNVWPSAP---GEGGWVPLQ-TFTQH 275 Query: 116 AGPISDISW-DFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPM 174 G + ++W ++ L G D + SG L V HSQ C + S Sbjct: 276 QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ---VCSILWSPHY 332 Query: 175 RSMTVGD---DGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKI 231 + + G +V ++ P A S V + SPD G V + +D + Sbjct: 333 KELISGHGFAQNQLVIWKYPTM---AKVAELKGHTSRVLSLTMSPD-GATVASAAADETL 388 Query: 232 SCF 234 + Sbjct: 389 RLW 391 Score = 50.3 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 40/210 (19%), Positives = 88/210 (41%), Gaps = 28/210 (13%) Query: 416 NDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSL-----SQNYVAVGLEEGNTIQ 470 + G + D+ + + + +GDI++ +++ PG +S NY+AVG Sbjct: 114 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAE--- 170 Query: 471 VFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFH 530 +L D++ L+ S+S + +++G G I +D++ E + + H Sbjct: 171 -VQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGH 229 Query: 531 TSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMK----IIKALNAHKDG 586 + ++ + W P + +A+G D + ++ P + ++ H+ Sbjct: 230 SQEVCGLRWAPDGRH----------LASGGNDNLVNVWP-SAPGEGGWVPLQTFTQHQGA 278 Query: 587 VNNLLWET-PSTLVSSGA---DACIKRWNV 612 V + W S ++++G D I+ WNV Sbjct: 279 VKAVAWCPWQSNVLATGGGTSDRHIRIWNV 308 Score = 45.7 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 19/140 (13%), Positives = 43/140 (30%), Gaps = 10/140 (7%) Query: 49 GDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNV 108 G+ P+ FT H +V G + +W ++V+ + Sbjct: 262 GEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS 321 Query: 109 KSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHL 168 + + I W + L N V + + + E+ GH+ R+ + + Sbjct: 322 Q---------VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTM 372 Query: 169 KQSRPMRSMTVGDDGSVVFY 188 + D ++ + Sbjct: 373 SPDG-ATVASAAADETLRLW 391 >5LCW-Q nrPDB Length = 374 Score = 95.0 bits (234), Expect = 8e-20, Method: Composition-based stats. Identities = 49/303 (16%), Positives = 101/303 (33%), Gaps = 36/303 (11%) Query: 73 SPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLC 132 G+ + V +W + S + ++ E IS ++W EG L Sbjct: 66 DWSSGNVLAVA--LDNSVYLWSAS----SGDILQLLQMEQPGEY--ISSVAWIKEGNYLA 117 Query: 133 VVGEGRDNFGVFISWD--SGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQG 190 V WD L ++ HS R+ + + G + + Sbjct: 118 VGTSS----AEVQLWDVQQQKRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHDV 170 Query: 191 PPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGE----FLKYIE 246 + + T V + ++PD G + + G+D ++ + GE L+ Sbjct: 171 RVAEHHVA--TLSGHSQEVCGLRWAPD-GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFT 227 Query: 247 DDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVA 306 Q V+ + + +D IR+W+V + C+ Q ++ Sbjct: 228 QHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-----QVCSILW 282 Query: 307 TGN-GRIISLS--LDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRI 359 + + +IS L ++ + + GH + +LT++P + S + D + Sbjct: 283 SPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETL 342 Query: 360 MEW 362 W Sbjct: 343 RLW 345 Score = 73.0 bits (177), Expect = 4e-13, Method: Composition-based stats. Identities = 65/377 (17%), Positives = 143/377 (37%), Gaps = 50/377 (13%) Query: 149 SGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSF 208 SG G+ R+ + +++ P + + P + D + + Sbjct: 9 SGKPQNAPEGYQNRLKVLYSQKATP-----GSSRKTCRYIPSLPDRIL--DAPEIRNDYY 61 Query: 209 VRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWL-DSQKF 267 + V++S + V+ V D + + SG+ L+ ++ +Q I +++W+ + Sbjct: 62 LNLVDWSSGN---VLAVALDNSVYLWSASSGDILQLLQMEQPGEY--ISSVAWIKEGNYL 116 Query: 268 ATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIIS-LSLDGTLNFYEL 326 A + A +++WDV K ++ T ++G + N I+S S G ++ +++ Sbjct: 117 AVGTSSAEVQLWDVQQQKRLRNMTSHSARVG------SLSWNSYILSSGSRSGHIHHHDV 170 Query: 327 GHDEV-LKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQDHSNLIVSLDNS 381 E + T+SGH++ + L P L SG D + W S+ L Sbjct: 171 RVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQT--FTQ 228 Query: 382 KAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIK 441 +++W Q V + T+D + I +G + Sbjct: 229 HQGAVKAVAWCPW-------------QSNVLATGGG------TSDRHIRIWNVCSGACLS 269 Query: 442 SVRLNSPGSAVSLSQNYVAVGLEEG---NTIQVFKLSDLEVSFDLKTPLRAKPSYISISP 498 +V +S ++ S +Y + G N + ++K + +LK ++ +++SP Sbjct: 270 AVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHT-SRVLSLTMSP 328 Query: 499 SETYIAAGDVMGKILLY 515 +A+ + L+ Sbjct: 329 DGATVASAAADETLRLW 345 Score = 61.5 bits (147), Expect = 9e-10, Method: Composition-based stats. Identities = 38/183 (20%), Positives = 60/183 (32%), Gaps = 18/183 (9%) Query: 56 VVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVL 115 V +GH V ++L SG V VW V ++ F Sbjct: 177 VATLSGHSQEV---CGLRWAPDGRHLASGGNDNLVNVWPSAP---GEGGWVPLQ-TFTQH 229 Query: 116 AGPISDISW-DFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPM 174 G + ++W ++ L G D + SG L V HSQ C + S Sbjct: 230 QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ---VCSILWSPHY 286 Query: 175 RSMTVGD---DGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKI 231 + + G +V ++ P A S V + SPD G V + +D + Sbjct: 287 KELISGHGFAQNQLVIWKYPTM---AKVAELKGHTSRVLSLTMSPD-GATVASAAADETL 342 Query: 232 SCF 234 + Sbjct: 343 RLW 345 Score = 49.9 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 40/210 (19%), Positives = 88/210 (41%), Gaps = 28/210 (13%) Query: 416 NDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSL-----SQNYVAVGLEEGNTIQ 470 + G + D+ + + + +GDI++ +++ PG +S NY+AVG Sbjct: 68 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAE--- 124 Query: 471 VFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFH 530 +L D++ L+ S+S + +++G G I +D++ E + + H Sbjct: 125 -VQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGH 183 Query: 531 TSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMK----IIKALNAHKDG 586 + ++ + W P + +A+G D + ++ P + ++ H+ Sbjct: 184 SQEVCGLRWAPDGRH----------LASGGNDNLVNVWP-SAPGEGGWVPLQTFTQHQGA 232 Query: 587 VNNLLWET-PSTLVSSGA---DACIKRWNV 612 V + W S ++++G D I+ WNV Sbjct: 233 VKAVAWCPWQSNVLATGGGTSDRHIRIWNV 262 Score = 45.7 bits (106), Expect = 7e-05, Method: Composition-based stats. Identities = 19/140 (13%), Positives = 43/140 (30%), Gaps = 10/140 (7%) Query: 49 GDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNV 108 G+ P+ FT H +V G + +W ++V+ + Sbjct: 216 GEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS 275 Query: 109 KSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHL 168 + + I W + L N V + + + E+ GH+ R+ + + Sbjct: 276 Q---------VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTM 326 Query: 169 KQSRPMRSMTVGDDGSVVFY 188 + D ++ + Sbjct: 327 SPDG-ATVASAAADETLRLW 345 >5L9T-R nrPDB Length = 493 Score = 93.4 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 46/287 (16%), Positives = 107/287 (37%), Gaps = 29/287 (10%) Query: 90 VIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDS 149 V +W ++ V + + ++ + W G L VG + G WD+ Sbjct: 209 VYLWSAC----TSQVTRLCDLSVEGDS--VTSVGWSERGN-LVAVGTHK---GFVQIWDA 258 Query: 150 --GNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGS 207 G L + GH+ R+ A + ++ G ++ + S+R Sbjct: 259 AAGKKLSMLEGHTARVGALAWNAEQ----LSSGSRDRMILQRDIRTPPLQSERRLQGHRQ 314 Query: 208 FVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKF 267 V +++S D + + + G+D K+ ++ S ++ + V+ ++ Sbjct: 315 EVCGLKWSTD-HQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLAS 373 Query: 268 ATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNG-RIISLS--LDGTLNFY 324 AD IR W+ T + +Q G+Q + + + ++S + + Sbjct: 374 GGGTADRCIRFWNTLTGQPLQCI-----DTGSQVCNLAWSKHANELVSTHGYSQNQILVW 428 Query: 325 ELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSM 367 + + ++GH+ + L ++P +++G+ D + W+ S Sbjct: 429 KYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSK 475 Score = 83.4 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 57/318 (17%), Positives = 119/318 (37%), Gaps = 32/318 (10%) Query: 14 PSTQRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFS 73 P Q +F +L + N ++ G + S+V + + G SV + Sbjct: 182 PELQDDFYLNLVDWSSLNVLSVGLGTCVY--LWSACTSQVTRLCDLSVEGDSVTSV---G 236 Query: 74 PIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCV 133 + + G G V +W K+ S + + ++W+ E +L Sbjct: 237 WSERGNLVAVGTHKGFVQIWDAAAGKKL--------SMLEGHTARVGALAWNAE--QLSS 286 Query: 134 VGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSM-TVGDDGSVVFYQGPP 192 R I S + GH Q + C LK S + + + G+D ++ + Sbjct: 287 GSRDRMILQRDIRTPPLQSERRLQGHRQEV--CGLKWSTDHQLLASGGNDNKLLVWNHSS 344 Query: 193 FKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGS--DRKISCFDGKSGEFLKYIEDDQE 250 + + + + + V+ + +SP + + G DR I ++ +G+ L+ I+ + Sbjct: 345 ---LSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQ 401 Query: 251 PVQGGIFALSWLDSQKFAT-VGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGN 309 A S ++ +T + I VW + V K T ++ + + + + Sbjct: 402 VCN---LAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRV----LYLAMSPD 454 Query: 310 GR-IISLSLDGTLNFYEL 326 G I++ + D TL F+ + Sbjct: 455 GEAIVTGAGDETLRFWNV 472 Score = 67.3 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 70/466 (15%), Positives = 151/466 (32%), Gaps = 54/466 (11%) Query: 69 TVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEG 128 +V F I ++ S ++ K K+ + +K+E AG E Sbjct: 58 SVNFHRINENEK--SPSQNRKAKDATSDNGKDGLAYSALLKNELLG-AGIEKVQDPQTED 114 Query: 129 RRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFY 188 RRL + + S G+ + ++ + + + Sbjct: 115 RRLQPSTPEKKGLFTYSL--STKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKIS 172 Query: 189 QGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDD 248 + P F D + ++ V++S + V++VG + + + + + D Sbjct: 173 KIP---FKVLDAPELQDDFYLNLVDWSSLN---VLSVGLGTCVYLWSACTSQVTRLC--D 224 Query: 249 QEPVQGGIFALSWLD-SQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVAT 307 + ++ W + A +++WD K + +VG +A Sbjct: 225 LSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHT-----ARVGALAW 279 Query: 308 GNGRIISLSLDGTLNFYELGHD--EVLKTISGHNKGITALTVNP----LISGSYDGRIME 361 ++ S S D + ++ + + + GH + + L + L SG D +++ Sbjct: 280 NAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLV 339 Query: 362 WSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTA 421 W+ SS+ + + L +AS Sbjct: 340 WNHSSLSPVQQ------------------YTEHLAAVKAIAWSPHQHGLLASGGG----- 376 Query: 422 VLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEG---NTIQVFKLSDLE 478 T D + + TG ++ + S ++ S++ + G N I V+K L Sbjct: 377 --TADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLT 434 Query: 479 VSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKT 524 L T + Y+++SP I G + +++ S+ T Sbjct: 435 QVAKL-TGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRST 479 Score = 60.7 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 37/201 (18%), Positives = 65/201 (32%), Gaps = 19/201 (9%) Query: 44 RCLDDGDSKVPPVVQ---FTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKE 100 R + D + PP+ GH V Q L SG K++VW + Sbjct: 291 RMILQRDIRTPPLQSERRLQGHRQEV---CGLKWSTDHQLLASGGNDNKLLVWNHS---- 343 Query: 101 SNSVEVNVKSEFQVLAGPISDISWDF-EGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGH 159 ++ ++ + I+W + L G D F + +G L + Sbjct: 344 ----SLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTG 399 Query: 160 SQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSG 219 SQ N K + + S ++ ++ P V + SPD G Sbjct: 400 SQVCNLAWSKHANELVSTHGYSQNQILVWKYPS---LTQVAKLTGHSYRVLYLAMSPD-G 455 Query: 220 EFVITVGSDRKISCFDGKSGE 240 E ++T D + ++ S Sbjct: 456 EAIVTGAGDETLRFWNVFSKT 476 Score = 53.0 bits (125), Expect = 4e-07, Method: Composition-based stats. Identities = 36/146 (24%), Positives = 63/146 (43%), Gaps = 22/146 (15%) Query: 468 TIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRW 527 T QV +L DL V D + + S +A G G + ++D + + K S Sbjct: 216 TSQVTRLCDLSVEGD-------SVTSVGWSERGNLVAVGTHKGFVQIWDAAAGK-KLSML 267 Query: 528 AFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRP-MKIIKALNAHKDG 586 HT+++ A++W + +++GS D I ++ P ++ + L H+ Sbjct: 268 EGHTARVGALAWNAEQ------------LSSGSRDRMILQRDIRTPPLQSERRLQGHRQE 315 Query: 587 VNNLLWETPSTLVSSGA-DACIKRWN 611 V L W T L++SG D + WN Sbjct: 316 VCGLKWSTDHQLLASGGNDNKLLVWN 341 Score = 39.5 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 26/162 (16%), Positives = 49/162 (30%), Gaps = 39/162 (24%) Query: 488 RAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKP------ 541 R + + S +A+G K+L+++ S ++ H + + AI+W P Sbjct: 313 RQEVCGLKWSTDHQLLASGGNDNKLLVWN-HSSLSPVQQYTEHLAAVKAIAWSPHQHGLL 371 Query: 542 ------------------------------AEKGANEEEIEEDLVATGSLDTNIFIYSVK 571 A + E + G I ++ Sbjct: 372 ASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYP 431 Query: 572 RPMKIIKALNAHKDGVNNLLWETPST-LVSSGADACIKRWNV 612 ++ K L H V L +V+ D ++ WNV Sbjct: 432 SLTQVAK-LTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472 >4XYI-A nrPDB Length = 430 Score = 93.4 bits (230), Expect = 3e-19, Method: Composition-based stats. Identities = 44/241 (18%), Positives = 85/241 (35%), Gaps = 32/241 (13%) Query: 156 VSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFS-------ASDRTHHKQGSF 208 + H+ + T +D S+ + S A +H+ + Sbjct: 178 LRHHTSEGFGLGWNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAV 237 Query: 209 VRDVEFSPDSGEFVITVGSDRKISCFDGK---SGEFLKYIEDDQEPVQGGIFALSWLDSQ 265 V D++F + +V D + D + S + ++ ++PV G F + Sbjct: 238 VNDLQFHLQHEALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNP--FNDY 295 Query: 266 KFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYE 325 AT AD T+ +WD+ + TL+ + V +++ S D + ++ Sbjct: 296 LLATASADHTVALWDLRRLNQ-RLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWD 354 Query: 326 L--------------GHDEVLKTISGHNKGITALTVNP-----LISGSYDGRIMEWSSSS 366 L G E++ GH ++ L+ NP L S + D + WS S Sbjct: 355 LSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWSPSK 414 Query: 367 M 367 + Sbjct: 415 V 415 Score = 50.3 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 47/358 (13%), Positives = 112/358 (31%), Gaps = 85/358 (23%) Query: 248 DQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWT------LDKQQLGNQQ 301 + V F D AT+G + ++D+ + L Sbjct: 130 HEGDVNKARFMPQNPDI--IATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFG 187 Query: 302 VGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPLISGSYDGRIME 361 +G G + + + D ++ +++ + S + I Sbjct: 188 LGWNFIQEGTLATGTEDTSICVWDIKGKSL----------------------SLEKSIDV 225 Query: 362 WSSSSMHQDHSNLIVSLDN--SKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGF 419 + S++ H+ ++ L +S+S D TL++ +S++ Sbjct: 226 -APVSVYHRHTAVVNDLQFHLQHEALLTSVSDDCTLQI--------HDTRLPSSSSASQC 276 Query: 420 TAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEV 479 + + F ++ + + + L + + EG+ +V+ + Sbjct: 277 VKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLNQRLHTLEGHEDEVYNVQ---- 332 Query: 480 SFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQ----------SREVKTSRW-- 527 +P E + ++ ++DL S + Sbjct: 333 ----WSP-----------HDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFM 377 Query: 528 -AFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHK 584 HT++++ +SW P K ++A+ + D + I+S P K+I A ++ K Sbjct: 378 HGGHTNRVSDLSWNPNNKW---------VLASLADDNILQIWS---PSKVIWASDSLK 423 Score = 49.9 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 36/216 (16%), Positives = 78/216 (36%), Gaps = 23/216 (10%) Query: 411 VASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQ 470 N +G+ L + I+Q+ ++ G + Q E +I Sbjct: 149 TLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGLGWNFIQEGTLATGTEDTSIC 208 Query: 471 VFKLSDLEVSFDLK---TPLRAKPSYISISPS-------ETYIAAGDVMGKILLYD--LQ 518 V+ + +S + P+ + ++ E + + + ++D L Sbjct: 209 VWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEALLTSVSDDCTLQIHDTRLP 268 Query: 519 SREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIK 578 S + H +N +++ P + L+AT S D + ++ ++R + + Sbjct: 269 SSSSASQCVKAHEQPVNGVAFNP---------FNDYLLATASADHTVALWDLRRLNQRLH 319 Query: 579 ALNAHKDGVNNLLWE--TPSTLVSSGADACIKRWNV 612 L H+D V N+ W LV+S D + W++ Sbjct: 320 TLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDL 355 Score = 36.4 bits (82), Expect = 0.039, Method: Composition-based stats. Identities = 17/133 (12%), Positives = 39/133 (29%), Gaps = 7/133 (5%) Query: 67 VTTVKFSPIKGSQYLCSGDESGKVIVWGWT-FDKESNSVEVNVKSEFQVLAGPISDISWD 125 V V F+P L + V +W ++ +++E + + V P + Sbjct: 284 VNGVAFNPFND-YLLATASADHTVALWDLRRLNQRLHTLEGHEDEVYNVQWSPHDEPILV 342 Query: 126 FEGRRLCVVGEGRDNFGVFISWDSGNS-----LGEVSGHSQRINACHLKQSRPMRSMTVG 180 V G + + + GH+ R++ + ++ Sbjct: 343 TSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLA 402 Query: 181 DDGSVVFYQGPPF 193 DD + + Sbjct: 403 DDNILQIWSPSKV 415 >4N14-A nrPDB Length = 314 Score = 93.1 bits (229), Expect = 3e-19, Method: Composition-based stats. Identities = 49/303 (16%), Positives = 101/303 (33%), Gaps = 36/303 (11%) Query: 73 SPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLC 132 G+ + V +W + S + ++ E IS ++W EG L Sbjct: 28 DWSSGNVLAVA--LDNSVYLWSAS----SGDILQLLQMEQPGEY--ISSVAWIKEGNYLA 79 Query: 133 VVGEGRDNFGVFISWD--SGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQG 190 V WD L ++ HS R+ + + G + + Sbjct: 80 VGTSS----AEVQLWDVQQQKRLRNMTSHSARVGSLSW---NSYILSSGSRSGHIHHHDV 132 Query: 191 PPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGE----FLKYIE 246 + + T V + ++PD G + + G+D ++ + GE L+ Sbjct: 133 RVAEHHVA--TLSGHSQEVCGLRWAPD-GRHLASGGNDNLVNVWPSAPGEGGWVPLQTFT 189 Query: 247 DDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVA 306 Q V+ + + +D IR+W+V + C+ Q ++ Sbjct: 190 QHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS-----QVCSILW 244 Query: 307 TGN-GRIISLS--LDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRI 359 + + +IS L ++ + + GH + +LT++P + S + D + Sbjct: 245 SPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETL 304 Query: 360 MEW 362 W Sbjct: 305 RLW 307 Score = 69.6 bits (168), Expect = 4e-12, Method: Composition-based stats. Identities = 56/304 (18%), Positives = 119/304 (39%), Gaps = 40/304 (13%) Query: 222 VITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWL-DSQKFATVGADATIRVWD 280 V+ V D + + SG+ L+ ++ +Q I +++W+ + A + A +++WD Sbjct: 34 VLAVALDNSVYLWSASSGDILQLLQMEQPGEY--ISSVAWIKEGNYLAVGTSSAEVQLWD 91 Query: 281 VTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIIS-LSLDGTLNFYELGHDEV-LKTISGH 338 V K ++ T ++G + N I+S S G ++ +++ E + T+SGH Sbjct: 92 VQQQKRLRNMTSHSARVG------SLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGH 145 Query: 339 NKGITALTVNP----LISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDT 394 ++ + L P L SG D + W S+ L +++W Sbjct: 146 SQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQT--FTQHQGAVKAVAWCP- 202 Query: 395 LKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSL 454 Q V + T+D + I +G + +V +S ++ Sbjct: 203 ------------WQSNVLATGGG------TSDRHIRIWNVCSGACLSAVDAHSQVCSILW 244 Query: 455 SQNYVAVGLEEG---NTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGK 511 S +Y + G N + ++K + +LK ++ +++SP +A+ Sbjct: 245 SPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHT-SRVLSLTMSPDGATVASAAADET 303 Query: 512 ILLY 515 + L+ Sbjct: 304 LRLW 307 Score = 60.3 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 36/180 (20%), Positives = 58/180 (32%), Gaps = 12/180 (6%) Query: 56 VVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVL 115 V +GH V ++L SG V VW V ++ F Sbjct: 139 VATLSGHSQEV---CGLRWAPDGRHLASGGNDNLVNVWPSAP---GEGGWVPLQ-TFTQH 191 Query: 116 AGPISDISW-DFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPM 174 G + ++W ++ L G D + SG L V HSQ + + + Sbjct: 192 QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKEL 251 Query: 175 RSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCF 234 S +V ++ P A S V + SPD G V + +D + + Sbjct: 252 ISGHGFAQNQLVIWKYPTM---AKVAELKGHTSRVLSLTMSPD-GATVASAAADETLRLW 307 Score = 56.5 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 42/320 (13%), Positives = 104/320 (32%), Gaps = 49/320 (15%) Query: 259 LSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLD 318 + W A D ++ +W ++ +Q +++ V + GN + + Sbjct: 27 VDWSSGNVLAVA-LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGN-YLAVGTSS 84 Query: 319 GTLNFYELGHDEVLKTISGHNKGITALTVNP--LISGSYDGRIMEWSS------SSMHQD 370 + +++ + L+ ++ H+ + +L+ N L SGS G I + Sbjct: 85 AEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSG 144 Query: 371 HSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLL 430 HS + L + + + +D L + + S P G+ + T Sbjct: 145 HSQEVCGLRWAPDGRHLASGGNDNL------VNVWPSAP-----GEGGWVPLQTFTQHQ- 192 Query: 431 ILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAK 490 + S A + + + + D ++ Sbjct: 193 ----GAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA----------HSQ 238 Query: 491 PSYISISPSETYIAAGD--VMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANE 548 I SP + +G +++++ + K + HTS++ +++ P Sbjct: 239 VCSILWSPHYKELISGHGFAQNQLVIWKYPT-MAKVAELKGHTSRVLSLTMSP------- 290 Query: 549 EEIEEDLVATGSLDTNIFIY 568 + VA+ + D + ++ Sbjct: 291 ---DGATVASAAADETLRLW 307 Score = 48.8 bits (114), Expect = 7e-06, Method: Composition-based stats. Identities = 40/209 (19%), Positives = 85/209 (40%), Gaps = 26/209 (12%) Query: 416 NDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSL-----SQNYVAVGLEEGNTIQ 470 + G + D+ + + + +GDI++ +++ PG +S NY+AVG Sbjct: 30 SSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAE--- 86 Query: 471 VFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFH 530 +L D++ L+ S+S + +++G G I +D++ E + + H Sbjct: 87 -VQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGH 145 Query: 531 TSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNA---HKDGV 587 + ++ + W P + +A+G D + ++ L H+ V Sbjct: 146 SQEVCGLRWAPDGRH----------LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAV 195 Query: 588 NNLLWET-PSTLVSSGA---DACIKRWNV 612 + W S ++++G D I+ WNV Sbjct: 196 KAVAWCPWQSNVLATGGGTSDRHIRIWNV 224 Score = 44.9 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 19/140 (13%), Positives = 43/140 (30%), Gaps = 10/140 (7%) Query: 49 GDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNV 108 G+ P+ FT H +V G + +W ++V+ + Sbjct: 178 GEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS 237 Query: 109 KSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHL 168 + + I W + L N V + + + E+ GH+ R+ + + Sbjct: 238 Q---------VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTM 288 Query: 169 KQSRPMRSMTVGDDGSVVFY 188 + D ++ + Sbjct: 289 SPDG-ATVASAAADETLRLW 307 >3ODT-A nrPDB Length = 313 Score = 92.7 bits (228), Expect = 4e-19, Method: Composition-based stats. Identities = 51/306 (16%), Positives = 94/306 (30%), Gaps = 56/306 (18%) Query: 154 GEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRT------------ 201 + GH Q + + +V DG+V + T Sbjct: 12 ATLKGHDQDVRDVVAVDD--SKVASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYDS 69 Query: 202 ------HHKQGSFVRDVEFSPDSGE---------------------FVITVGSDRKISCF 234 + + + V SGE VI+ D+ + Sbjct: 70 EKELLLFGGKDTMINGVPLFATSGEDPLYTLIGHQGNVCSLSFQDGVVISGSWDKTAKVW 129 Query: 235 DGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDK 294 K G + ++ V + KF T AD TI++W K ++ ++ Sbjct: 130 --KEGSLVYNLQAHNASVWDAK--VVSFSENKFLTASADKTIKLW--QNDKVIKTFSG-- 181 Query: 295 QQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP---LI 351 + + +G IS S DG + ++ +VL+T GH + + + P ++ Sbjct: 182 -IHNDVVRHLAVVDDGHFISCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGDIV 240 Query: 352 SGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKV 411 S D + W S +++L +S D + + SQ K Sbjct: 241 SCGEDRTVRIW---SKENGSLKQVITLPAISIWSVDCMSNGDIIVGSSDNLVRIFSQEKS 297 Query: 412 ASANND 417 A+ D Sbjct: 298 RWASED 303 Score = 45.3 bits (105), Expect = 9e-05, Method: Composition-based stats. Identities = 42/291 (14%), Positives = 94/291 (32%), Gaps = 56/291 (19%) Query: 330 EVLKTISGHNKGITALTV---NPLISGSYDGRIMEWSSSSMHQD-----HSNLIVSLDNS 381 ++ T+ GH++ + + + + S S DG + WS + S+ Sbjct: 9 QLSATLKGHDQDVRDVVAVDDSKVASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYD 68 Query: 382 KAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIK 441 +E DT+ +NG+ P A++ D + Sbjct: 69 SEKELLLFGGKDTM-INGV--------PLFATSGED--------------------PLYT 99 Query: 442 SVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSET 501 + ++S V G + T +V+K L + +S S ++ Sbjct: 100 LIGHQGNVCSLSFQDGVVISGSWD-KTAKVWKEGSLVYNLQAHNASVWDAKVVSFSENKF 158 Query: 502 YIAAGDVMGKILLYDLQSREVKTSRWAF-HTSKINAISWKPAEKGANEEEIEEDLVATGS 560 A+ D I L+ + ++ H + ++ +++ + S Sbjct: 159 LTASAD--KTIKLWQ---NDKVIKTFSGIHNDVVRHLA-----------VVDDGHFISCS 202 Query: 561 LDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSGADACIKRWN 611 D I + + +++ H+ V + +VS G D ++ W+ Sbjct: 203 NDGLIKLVDMH-TGDVLRTYEGHESFVYCIKLLPNGDIVSCGEDRTVRIWS 252 >6CHG-A nrPDB Length = 312 Score = 86.1 bits (211), Expect = 4e-17, Method: Composition-based stats. Identities = 44/311 (14%), Positives = 100/311 (32%), Gaps = 46/311 (14%) Query: 64 SSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDIS 123 + T+ + SP +C + ++V+ + K I+ + Sbjct: 13 GKISTSCQISPDGELIAICQNTD---MLVYEISSSKMMKLTT--------THKECINCLC 61 Query: 124 WDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDG 183 W + + + E I + + + GH+ + + + + D Sbjct: 62 WSPDSKCIASGSEDFTVEITHIIY---GRIRRLMGHTAPVISICYNNKGNIL-CSSSMDE 117 Query: 184 SVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLK 243 S+ + + +T V ++ + + D I FD +SG LK Sbjct: 118 SIKEWHVLS---GTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLK 174 Query: 244 YI--------EDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWT-LDK 294 + ED P+ F+ + + D +++W+ T V+ + + Sbjct: 175 TLTYDKDWIAEDGVVPISTVKFS---RNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQ 231 Query: 295 QQLGNQQVGV------VATGNGRIISLSLDGTLNFYELGHDEVLKTI-SGHNKGITALTV 347 + + + +IS + G++ + + +++ I H Sbjct: 232 ETKAKLKYNCGLELIYPQGKDPLVISGNDSGSMCVWNVYSKNLVQKIDEKHRN------- 284 Query: 348 NPL--ISGSYD 356 +PL IS SYD Sbjct: 285 SPLISISASYD 295 Score = 70.3 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 51/307 (16%), Positives = 110/307 (35%), Gaps = 51/307 (16%) Query: 202 HHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSW 261 G + SPD I +D + ++ S + +K +E + L W Sbjct: 9 LPASGKISTSCQISPDGELIAICQNTD--MLVYEISSSKMMKLTTTHKECIN----CLCW 62 Query: 262 -LDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGT 320 DS+ A+ D T+ + + + +++ + S S+D + Sbjct: 63 SPDSKCIASGSEDFTVEITHIIYGR-IRRLMGHTAP---VISICYNNKGNILCSSSMDES 118 Query: 321 LNFYELGHDEVLKTISGHNKGITALTV-----NPLISGSYDGRIMEWSSSSMH------- 368 + + + LKT+S H+ + ++ + + L SGSYDG I + + S H Sbjct: 119 IKEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTY 178 Query: 369 ------QDHSNLIVSLDNSKAQEYSSI-SWDDTLKVNGITKHEFGSQ------------- 408 +D I ++ S+ ++ + S D+ +K+ T+ Sbjct: 179 DKDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLK 238 Query: 409 ---PKVASANNDGFTAVLTNDD--DLLILQSFTGDIIKSVR---LNSPGSAVSLSQNYVA 460 V++ +D + + ++ ++++ + NSP ++S S + VA Sbjct: 239 YNCGLELIYPQGKDPLVISGNDSGSMCVWNVYSKNLVQKIDEKHRNSPLISISASYDKVA 298 Query: 461 VGLEEGN 467 G Sbjct: 299 TLSLNGE 305 Score = 66.1 bits (159), Expect = 4e-11, Method: Composition-based stats. Identities = 39/302 (12%), Positives = 99/302 (32%), Gaps = 40/302 (13%) Query: 297 LGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LIS 352 G + +G +I++ + + YE+ +++K + H + I L +P + S Sbjct: 12 SGKISTSCQISPDGELIAICQNTDMLVYEISSSKMMKLTTTHKECINCLCWSPDSKCIAS 71 Query: 353 GSYDGRIMEWSSSSMH----QDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQ 408 GS D + H+ ++S+ + S Sbjct: 72 GSEDFTVEITHIIYGRIRRLMGHTAPVISICYNNKGNILCSS-------------SMDES 118 Query: 409 PKVASANNDGFTAVLTNDDDLLI---LQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEE 465 K + ++ D ++ + F I+ S + E Sbjct: 119 IKEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDT---------ES 169 Query: 466 GNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYD-LQSREVKT 524 G+ ++ ++ D P+ S + S + ++ + + L++ + V+T Sbjct: 170 GHCLKTLTYDKDWIAEDGVVPI----STVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRT 225 Query: 525 SRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHK 584 W H + + + + + LV +G+ ++ +++V + K H+ Sbjct: 226 FLWP-HQETKAKLKYNCGLELIYPQGKDP-LVISGNDSGSMCVWNVYSKNLVQKIDEKHR 283 Query: 585 DG 586 + Sbjct: 284 NS 285 Score = 30.3 bits (66), Expect = 2.4, Method: Composition-based stats. Identities = 14/53 (26%), Positives = 30/53 (56%), Gaps = 2/53 (3%) Query: 552 EEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSGAD 604 + +L+A +T++ +Y + K++K HK+ +N L W S ++SG++ Sbjct: 24 DGELIAICQ-NTDMLVYEIS-SSKMMKLTTTHKECINCLCWSPDSKCIASGSE 74 >4J0W-A nrPDB Length = 343 Score = 86.1 bits (211), Expect = 4e-17, Method: Composition-based stats. Identities = 33/266 (12%), Positives = 80/266 (30%), Gaps = 40/266 (15%) Query: 158 GHSQRINACHLKQSRPMRSMTVGDDGS--VVFYQGPPFKFSASDRTHHKQGSFVRDVEFS 215 GHS + + D S ++ ++ + T V + F Sbjct: 65 GHSSHVLCMAISSDGKYL---ASGDRSKLILIWEAQSCQH---LYTFTGHRDAVSGLAFR 118 Query: 216 PDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADAT 275 + + + + DR + ++ +++ + Q+ V + A G D T Sbjct: 119 RGTHQ-LYSTSHDRSVKVWNVAENSYVETLFGHQDAV--AALDALSRECCVTA-GGRDGT 174 Query: 276 IRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKT- 334 +RVW + + + + + + ++S + DG++ + L L Sbjct: 175 VRVWKIPEESQLVFY-GHQGSIDC----IHLINEEHMVSGADDGSVALWGLSKKRPLALQ 229 Query: 335 -----ISGH---------NKGITALTVNPLISGSYDGRIMEWSSSSMHQDHS-------- 372 + G + L + + +GS+ + W + Sbjct: 230 REAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPLV 289 Query: 373 NLIVSLDNSKAQEYSSISWDDTLKVN 398 I SL S + ++ ++ Sbjct: 290 GFINSLKFSSSGDFLVAGVGQEHRLG 315 Score = 76.1 bits (185), Expect = 5e-14, Method: Composition-based stats. Identities = 44/272 (16%), Positives = 88/272 (32%), Gaps = 40/272 (14%) Query: 61 GHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPIS 120 GH S V+ + +YL SGD S +++W E+ S + F +S Sbjct: 65 GHSSHVLC---MAISSDGKYLASGDRSKLILIW------EAQSCQHLYT--FTGHRDAVS 113 Query: 121 DISWDFEGRRLCVVGEGRDNFGVFISWDSGNS--LGEVSGHSQRINACHLKQSRPMRSMT 178 +++ +L R W+ + + + GH + A SR Sbjct: 114 GLAFRRGTHQLYSTSHDRS----VKVWNVAENSYVETLFGHQDAVAALD-ALSRECCVTA 168 Query: 179 VGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKS 238 G DG+V ++ P + + + + +++ D ++ + Sbjct: 169 GGRDGTVRVWKIPEESQLV----FYGHQGSIDCIHLINEEH--MVSGADDGSVALWGLSK 222 Query: 239 GEFLKYI-EDDQEPVQGGIFALSW-------LDSQKFATVGADATIRVWDVTTSKCVQKW 290 L E + G+ W L++ AT + +R+W +C + + Sbjct: 223 KRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLW-----QCGEGF 277 Query: 291 TLDKQQLGNQQVGVVATGNGRIISLSLDGTLN 322 VG + + S S D + Sbjct: 278 RQLDLLCDIPLVGFINSLK---FSSSGDFLVA 306 Score = 71.9 bits (174), Expect = 7e-13, Method: Composition-based stats. Identities = 29/243 (11%), Positives = 73/243 (30%), Gaps = 33/243 (13%) Query: 242 LKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDK------- 294 ++ + Q + + D + D +I W V + + + K Sbjct: 7 IRVLRGHQLSITCLVVT---PDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKP 63 Query: 295 -QQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTV----NP 349 + +++ + S + +E + L T +GH ++ L + Sbjct: 64 PGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQ 123 Query: 350 LISGSYDGRIMEWSSSSM-----HQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHE 404 L S S+D + W+ + H + + +LD ++S + +T Sbjct: 124 LYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALD--------ALSRECC-----VTAGG 170 Query: 405 FGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLE 464 +V + + + + + + S + + LS+ Sbjct: 171 RDGTVRVWKIPEESQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQR 230 Query: 465 EGN 467 E + Sbjct: 231 EAH 233 Score = 55.3 bits (131), Expect = 7e-08, Method: Composition-based stats. Identities = 32/189 (16%), Positives = 82/189 (43%), Gaps = 18/189 (9%) Query: 428 DLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPL 487 D+ +L+ I V + S +++ + + ++ + + + K P Sbjct: 6 DIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPG 65 Query: 488 RAKPSYI---SISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEK 544 + S++ +IS Y+A+GD IL+++ QS + + H ++ ++++ + Sbjct: 66 HS--SHVLCMAISSDGKYLASGDRSKLILIWEAQSCQ-HLYTFTGHRDAVSGLAFR---R 119 Query: 545 GANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSGA- 603 G ++ + + S D ++ +++V ++ L H+D V L + V++G Sbjct: 120 GTHQ-------LYSTSHDRSVKVWNVAENS-YVETLFGHQDAVAALDALSRECCVTAGGR 171 Query: 604 DACIKRWNV 612 D ++ W + Sbjct: 172 DGTVRVWKI 180 >4XFV-A nrPDB Length = 792 Score = 85.4 bits (209), Expect = 7e-17, Method: Composition-based stats. Identities = 62/414 (14%), Positives = 129/414 (31%), Gaps = 73/414 (17%) Query: 175 RSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCF 234 + + G ++ + T + V V F PD +F+++ D + + Sbjct: 32 KIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPD-SDFMVSASEDHHVKIW 90 Query: 235 ---DGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVW--DVTTSK--CV 287 D + ++ I+ + AL L + AD TI +W ++ + Sbjct: 91 KFTDYSHLQCIQTIQ-HYSKTIVALSALPSL----ISVGCADGTISIWRQNIQNDEFGLA 145 Query: 288 QKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFY---------ELGHDEVLKTISGH 338 ++T+ K + + + + +N + + V+ + GH Sbjct: 146 HEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGH 205 Query: 339 NKGITALTV--------NPLISGSYDGRIMEW-----SSSSMHQDHSNLIVSLDNSKAQE 385 + +L L SGS D I W ++ S + L N + + Sbjct: 206 EDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKF 265 Query: 386 YSSISWDDTLKVN------------GITKHEFG-SQPKVASANNDGFTAVLTNDDDLLIL 432 DD L+V I+ ++ S+ ++ +A D V D+ I Sbjct: 266 QI----DDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIW 321 Query: 433 QSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLK-------- 484 + + +A S + + + F + S+ + Sbjct: 322 VC--SLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIIC 379 Query: 485 ------TPLRAKPSYISISPSETYIAAGDVMGKILL-----YDLQSREVKTSRW 527 + + I+ SPS Y+ A + L YD R+ + + W Sbjct: 380 DQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATW 433 Score = 73.8 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 75/564 (13%), Positives = 162/564 (28%), Gaps = 101/564 (17%) Query: 47 DDGDSKVPPVVQFTGHGSSVVTTV-KFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVE 105 D G K V + GH V + + G LCSG + + +W + + E Sbjct: 190 DSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSE 249 Query: 106 VNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINA 165 + K +S+ + F+ D V I+++ + GH I++ Sbjct: 250 EDSKKLTL-----LSNKQYKFQ---------IDDELRVGINFE-----ALIMGHDDWISS 290 Query: 166 CHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHH--------------KQGSFVRD 211 +SR ++ + D S++ ++ P + G F Sbjct: 291 LQWHESR-LQLLAATADTSLMVWE-PDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSC 348 Query: 212 VEFSPDSGEFVITVGSDRKISCFDGKSGEFLKY---IEDDQEPVQGGIFALSWLDSQKFA 268 + F+ + +F +T G + K I + V ++ S + Sbjct: 349 LWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPS---GEYLL 405 Query: 269 TVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGH 328 D T R++ + ++ + D Sbjct: 406 ATSLDQTTRLFAP------WIYDASGRKREIATWHEFSRPQIH----GYDMIC------- 448 Query: 329 DEVLKTISGHNKGITALTVNPLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSS 388 + +T +SG + + + V + + E Sbjct: 449 -------------VETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPD 495 Query: 389 ISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSV----- 443 + L ++ + ++ + T +T+ LL + + + Sbjct: 496 SATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEV 555 Query: 444 ------RLNSPGSAVSLSQNYVA-VGLEEGNTIQVFKLSDLEVSFDLKT--PLRA-KPSY 493 +S Q +A V ++ E ++K P + + Sbjct: 556 EKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITR 615 Query: 494 ISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAF-----HTSKINAISWKPAEKGANE 548 + S ++ + K L++ ++ E T F HT I W P E G Sbjct: 616 LKFSKDGKFLLSVCRDRKWALWE-RNMEDNTFELRFKNEKPHTRIIWDADWAPLEFG--- 671 Query: 549 EEIEEDLVATGSLDTNIFIYSVKR 572 ++ T S D + ++ ++ Sbjct: 672 -----NVFVTASRDKTVKVWRHQK 690 Score = 61.5 bits (147), Expect = 1e-09, Method: Composition-based stats. Identities = 32/199 (16%), Positives = 69/199 (34%), Gaps = 18/199 (9%) Query: 152 SLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDR---THHKQGSF 208 + ++ GH I + + + +V F Sbjct: 554 EVEKLYGHGFEITCLDISPDQ-KLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLT 612 Query: 209 VRDVEFSPDSGEFVITVGSDRKISCF--DGKSGEFLKYIEDDQEPVQGGIFALSWLD--- 263 + ++FS D G+F+++V DRK + + + + F ++ ++P I+ W Sbjct: 613 ITRLKFSKD-GKFLLSVCRDRKWALWERNMEDNTFELRFKN-EKPHTRIIWDADWAPLEF 670 Query: 264 SQKFATVGADATIRVW----DVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDG 319 F T D T++VW + ++ + + + +IS+ L+ Sbjct: 671 GNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLEN 730 Query: 320 ---TLNFYELGHDEVLKTI 335 L Y LG E++ + Sbjct: 731 GEIYLYSYTLGKFELITQL 749 Score = 56.5 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 60/377 (15%), Positives = 120/377 (31%), Gaps = 61/377 (16%) Query: 262 LDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTL 321 +K GA TI +WD + K + ++S S D + Sbjct: 28 HKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHV 87 Query: 322 NFY---ELGHDEVLKTISGHNKGITALTVNP-LIS-GSYDGRIMEWSSSSMHQDHSN--- 373 + + H + ++TI ++K I AL+ P LIS G DG I W + + + Sbjct: 88 KIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHE 147 Query: 374 ----------LIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAV- 422 L +SL + ++Y L + G + F + ++ + + V Sbjct: 148 FTIKKGFFYPLCLSLSKVEEKKYL-------LAIGGTNVNVFIASFILSDSGIEKCRVVA 200 Query: 423 -LTNDDD-----LLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSD 476 L +D Q GD + + + + E ++ ++ LS+ Sbjct: 201 ELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSN 260 Query: 477 LEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINA 536 + F + LR ++ ++ + + S +H S++ Sbjct: 261 KQYKFQIDDELRVGINFEAL--------------------IMGHDDWISSLQWHESRLQL 300 Query: 537 ISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPS 596 ++ E E + SL + K G + LW T Sbjct: 301 LAATADTSLMVWEPDETSGIWVCSLRLG------EMSSKGASTATGSSGGFWSCLWFTHE 354 Query: 597 TL---VSSGADACIKRW 610 + +++G + W Sbjct: 355 RMDFFLTNGKTGSWRMW 371 Score = 45.7 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 20/158 (12%), Positives = 48/158 (30%), Gaps = 8/158 (5%) Query: 114 VLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSG----HSQRINACHLK 169 I+ + + + + + I S + E+ HS I Sbjct: 560 GHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFS 619 Query: 170 QSRPMRSMTVGDDGSVVFYQGP--PFKFSASDRTHHKQGSFVRDVEFSP-DSGEFVITVG 226 + ++V D ++ F + + D +++P + G +T Sbjct: 620 KDGKFL-LSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTAS 678 Query: 227 SDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDS 264 D+ + + + Y+ + + A+S DS Sbjct: 679 RDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDS 716 Score = 37.2 bits (84), Expect = 0.023, Method: Composition-based stats. Identities = 24/145 (16%), Positives = 47/145 (32%), Gaps = 18/145 (12%) Query: 261 WLDSQKFATVGA-----DATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISL 315 D + A+ +A IR++ ++ L L ++ ++S+ Sbjct: 571 SPDQKLIASACRSNNVQNAVIRIFSTENWLEIKP-ALPFHSLTITRLKFS-KDGKFLLSV 628 Query: 316 SLDGTLNFYELGHDEVLKTIS-----GHNKGITALTVNPL------ISGSYDGRIMEWSS 364 D +E ++ + H + I PL ++ S D + W Sbjct: 629 CRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRH 688 Query: 365 SSMHQDHSNLIVSLDNSKAQEYSSI 389 D L S+ ++KA SI Sbjct: 689 QKEPADDYVLEASIKHTKAVTAISI 713 >4YCZ-A nrPDB Length = 876 Score = 85.0 bits (208), Expect = 9e-17, Method: Composition-based stats. Identities = 45/269 (16%), Positives = 82/269 (30%), Gaps = 38/269 (14%) Query: 37 CGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWT 96 C ++ + GH +V P G+ L S GKV++W Sbjct: 36 CSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPKYGN-ILASAGYDGKVLIWR-- 92 Query: 97 FDKESNSVEVNVKSE----FQVLAGPISDISWDFEGRRLCVVGEGRD-NFGVFISWDSGN 151 E+N + F + ++ +SW + D N V D+ Sbjct: 93 --------ELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNVSVLEFRDNSW 144 Query: 152 SLGEVSGHSQRINACH----------------LKQSRPMRSMTVGDDGSVVFYQGPPF-- 193 H +N+ K + R +T G D ++ + P Sbjct: 145 EHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATN 204 Query: 194 KFSASDRTHHKQGSFVRDVEFSPD--SGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEP 251 + +VRDV +SP ++ + DR + + L++ Sbjct: 205 TYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPANPLQW-NCKVLN 263 Query: 252 VQGGIFALSW-LDSQKFATVGADATIRVW 279 ++ +SW L A G D + +W Sbjct: 264 FDAAVWRVSWSLSGNVLAASGGDNKVTLW 292 Score = 83.4 bits (204), Expect = 3e-16, Method: Composition-based stats. Identities = 42/252 (16%), Positives = 83/252 (32%), Gaps = 37/252 (14%) Query: 150 GNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFV 209 G + SGH I+ L R T D ++ ++ + T V Sbjct: 8 GTQVIANSGHDDMIHDAVLDYYG-RRLATCSSDRTIKIFEIE-GETQRLTETLKGHDGAV 65 Query: 210 RDVEFS-PDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQK-- 266 V ++ P G + + G D K+ + +G + + D + + +SW + Sbjct: 66 WCVSWAHPKYGNILASAGYDGKVLIWRELNGAWQRIF--DFALHKASVNVVSWSPHEAGC 123 Query: 267 -FATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQV----------------GVVATGN 309 A +D + V + + + LG V G +TGN Sbjct: 124 LLACASSDGNVSVLEFRDNS-WEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGN 182 Query: 310 GRIISLSLDGTLNFYE----LGHDEVLKT-ISGHNKGITALTVNP-------LISGSYDG 357 R ++ D L + ++ + ++GH + + +P + S S D Sbjct: 183 RRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDR 242 Query: 358 RIMEWSSSSMHQ 369 + W+S + Sbjct: 243 TVRIWTSDPANP 254 Score = 81.9 bits (200), Expect = 7e-16, Method: Composition-based stats. Identities = 40/277 (14%), Positives = 85/277 (30%), Gaps = 42/277 (15%) Query: 78 SQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFE--GRRLCVVG 135 + L + + ++ E + + G + +SW G L G Sbjct: 30 GRRLATCSSDRTIKIF------EIEGETQRLTETLKGHDGAVWCVSWAHPKYGNILASAG 83 Query: 136 EGRDNFGVFISWDSGN----SLGEVSGHSQRINACHLKQSRPMRSMT-VGDDGSVVFYQG 190 G + W N + + + H +N + DG+V + Sbjct: 84 YD----GKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNVSVLEF 139 Query: 191 PPFKFSASDRTHHKQGSFVRDVEFSPDSGE----------------FVITVGSDRKISCF 234 + S H G V V ++P + +T GSD + + Sbjct: 140 RDNSWEHSI--FHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNALKIW 197 Query: 235 --DGKSGE---FLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQK 289 D + + + + V+ ++ + L A+ D T+R+W + +Q Sbjct: 198 AYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPANPLQ- 256 Query: 290 WTLDKQQLGNQQVGVVATGNGRIISLS-LDGTLNFYE 325 W V + +G +++ S D + ++ Sbjct: 257 WNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVTLWK 293 Score = 65.7 bits (158), Expect = 5e-11, Method: Composition-based stats. Identities = 59/356 (16%), Positives = 108/356 (30%), Gaps = 92/356 (25%) Query: 280 DVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELG--HDEVLKTISG 337 + V + + + + R+ + S D T+ +E+ + +T+ G Sbjct: 4 SMAAGTQVIANSGHDDMIHDAVLDYY---GRRLATCSSDRTIKIFEIEGETQRLTETLKG 60 Query: 338 HNKGITALT-VNP-----LISGSYDGRIME-------WSSSSMHQDHSNLIVSLDNSKAQ 384 H+ + ++ +P L S YDG+++ W H + Sbjct: 61 HDGAVWCVSWAHPKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVN-------- 112 Query: 385 EYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTG-----DI 439 +SW + +A A++DG +VL D+ F + Sbjct: 113 ---VVSWSPH-----------EAGCLLACASSDGNVSVLEFRDNSWEHSIFHAHGLGVNS 158 Query: 440 IKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPS 499 + SPGS VS +KP S Sbjct: 159 VSWAPATSPGSIVS-----------------------------------SKPGPKSTGNR 183 Query: 500 ETYIAAGDVMGKILLYDLQSREVKTSR--WAFHTSKINAISWKPAEKGANEEEIEEDLVA 557 D KI YD + K R HT + ++W P +++ +A Sbjct: 184 RFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSP-------TVLQKSYIA 236 Query: 558 TGSLDTNIFIY--SVKRPMKIIKALNAHKDGVNNLLWETPST-LVSSGADACIKRW 610 + S D + I+ P++ + V + W L +SG D + W Sbjct: 237 SASEDRTVRIWTSDPANPLQWNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVTLW 292 >2AQ5-A nrPDB Length = 402 Score = 83.8 bits (205), Expect = 2e-16, Method: Composition-based stats. Identities = 33/187 (17%), Positives = 66/187 (35%), Gaps = 13/187 (6%) Query: 151 NSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDR----THHKQG 206 ++ V GH+ + + +D +V+ ++ P R T Sbjct: 72 KNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHT 131 Query: 207 SFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSW-LDSQ 265 V V + P + +++ G D I +D +G + + D P I+++ W D Sbjct: 132 KRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHP--DTIYSVDWSRDGA 189 Query: 266 KFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGT----L 321 T D +RV + V + D+ G + V V G+I++ + Sbjct: 190 LICTSCRDKRVRVIEPRKGTVVAE--KDRPHEGTRPVHAVFVSEGKILTTGFSRMSERQV 247 Query: 322 NFYELGH 328 ++ H Sbjct: 248 ALWDTKH 254 Score = 56.1 bits (133), Expect = 4e-08, Method: Composition-based stats. Identities = 45/239 (18%), Positives = 79/239 (33%), Gaps = 24/239 (10%) Query: 56 VVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVL 115 V GH + V+ + + P + + SG E V+VW + V + Sbjct: 74 VPLVCGHTAPVL-DIAWCPHNDN-VIASGSEDCTVMVWEIPDGGLVLPLREPVI-TLEGH 130 Query: 116 AGPISDISWD-FEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSG----HSQRINACHLKQ 170 + ++W L G V + WD G ++ H I + + Sbjct: 131 TKRVGIVAWHPTAQNVLLSAGCD----NVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSR 186 Query: 171 SRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGS--- 227 T D V + A H+ V V S ++T G Sbjct: 187 DG-ALICTSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAVFVSE---GKILTTGFSRM 242 Query: 228 -DRKISCFDGKS-GEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGA-DATIRVWDVTT 283 +R+++ +D K E L E D G + D+ G D++IR +++T+ Sbjct: 243 SERQVALWDTKHLEEPLSLQELDTS--SGVLLPFFDPDTNIVYLCGKGDSSIRYFEITS 299 Score = 50.3 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 37/217 (17%), Positives = 77/217 (35%), Gaps = 44/217 (20%) Query: 302 VGVVATG--NGRIISLSLDGTLNFYELGHD-------EVLKTISGHNKGITALTVNP--- 349 + + + I S S D T+ +E+ E + T+ GH K + + +P Sbjct: 85 LDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQ 144 Query: 350 --LISGSYDGRIMEWSSSSM------HQD-HSNLIVSLDNSKAQEYSSISW-DDTLKVNG 399 L+S D I+ W + D H + I S+D S+ S D ++V Sbjct: 145 NVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCRDKRVRVIE 204 Query: 400 ITKHEF---------GSQPKVASANNDGFTAVL----TNDDDLLILQSFTGDIIKSVRLN 446 K G++P A ++G ++ + + T + + + L Sbjct: 205 PRKGTVVAEKDRPHEGTRPVHAVFVSEGKILTTGFSRMSERQVALWD--TKHLEEPLSLQ 262 Query: 447 SPGSA-------VSLSQNYVAVGLEEGNTIQVFKLSD 476 ++ N V + + ++I+ F+++ Sbjct: 263 ELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITS 299 Score = 49.9 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 22/125 (17%), Positives = 50/125 (40%), Gaps = 20/125 (16%) Query: 494 ISISP-SETYIAAGDVMGKILLYDLQS-------REVKTSRWAFHTSKINAISWKPAEKG 545 I+ P ++ IA+G ++++++ RE HT ++ ++W P Sbjct: 87 IAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVI-TLEGHTKRVGIVAWHP---- 141 Query: 546 ANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIK-ALNAHKDGVNNLLWETPSTLVS-SGA 603 + L++ G D I ++ V ++ + H D + ++ W L+ S Sbjct: 142 ----TAQNVLLSAGC-DNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCR 196 Query: 604 DACIK 608 D ++ Sbjct: 197 DKRVR 201 >6J6H-n nrPDB Length = 455 Score = 83.4 bits (204), Expect = 3e-16, Method: Composition-based stats. Identities = 51/309 (16%), Positives = 103/309 (33%), Gaps = 40/309 (12%) Query: 196 SASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDG-KSGEFLKYIEDDQEPVQG 254 R + ++F P +G +++ G+D I +D E L+ + +P++ Sbjct: 152 KKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKA 211 Query: 255 GIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIIS 314 F D Q F + D ++++WD T K + L+ + + I+ Sbjct: 212 LRFT---EDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVE--SRPTNPHEFIVG 266 Query: 315 LSLDGTLNFYELGH--DEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSS---- 364 LS L++ + +++T H I AL P IS S D + W + Sbjct: 267 LSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINV 326 Query: 365 ----SSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKV--------- 411 S HS +++ +Q Y D + K ++ PK Sbjct: 327 PIKQISDTAQHSMPFLNVH--PSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAG 384 Query: 412 ----ASANNDG-FTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLS----QNYVAVG 462 + + DG + + L T ++ ++++ + + + Sbjct: 385 YGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVIC 444 Query: 463 LEEGNTIQV 471 I V Sbjct: 445 SGAAGKIYV 453 Score = 78.4 bits (191), Expect = 8e-15, Method: Composition-based stats. Identities = 40/278 (14%), Positives = 87/278 (31%), Gaps = 56/278 (20%) Query: 151 NSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVR 210 + GH + A ++ G+D ++ + + R ++ Sbjct: 153 KVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF--YHDYECLRDFQGHNKPIK 210 Query: 211 DVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEP------------------- 251 + F+ D F ++ DR + +D ++G+ + + P Sbjct: 211 ALRFTEDCQSF-LSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSN 269 Query: 252 ----------------------VQGGIFAL-SWLDSQKFATVGADATIRVWDVTTSKCVQ 288 I AL + D KF + D T+R+W+ + ++ Sbjct: 270 SKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIK 329 Query: 289 KWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELG---HDEVLKTISGHNK--GIT 343 + + D Q + V + N + S+D + + L K GH+ Sbjct: 330 QIS-DTAQHSMPFLNVHPSQN-YFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGI 387 Query: 344 ALTVNP----LISGSYDGRIMEWSSSSMHQDHSNLIVS 377 +L + + SG R+ W ++ ++ I Sbjct: 388 SLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPG 425 Score = 75.3 bits (183), Expect = 7e-14, Method: Composition-based stats. Identities = 59/287 (20%), Positives = 96/287 (33%), Gaps = 45/287 (15%) Query: 294 KQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHD-EVLKTISGHNKGITALTVN---- 348 G + + I+S D T+ ++ HD E L+ GHNK I AL Sbjct: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQ 219 Query: 349 PLISGSYDGRIMEWSSSSMH------------------QDHSNLIVSLDNSKAQEY---- 386 +S S+D + W + + + IV L NSK Y Sbjct: 220 SFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRV 279 Query: 387 -----SSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIK 441 ++D L K+ K S++ D + N ++ I Q I Sbjct: 280 SENQGLVQTYDHHLSSILALKYFPDGS-KFISSSEDKTVRIWENQINVPIKQ-----ISD 333 Query: 442 SVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPS-----YISI 496 + + + P V SQNY + N I F L + K + S ++ Sbjct: 334 TAQHSMPFLNVHPSQNYFCAQSMD-NRIYSFSLKP-KYKRHPKKIFKGHSSAGYGISLAF 391 Query: 497 SPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAE 543 S YI +GD ++ +D + + + I + W P E Sbjct: 392 SGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQE 438 Score = 51.8 bits (122), Expect = 8e-07, Method: Composition-based stats. Identities = 40/224 (17%), Positives = 66/224 (29%), Gaps = 18/224 (8%) Query: 20 FTTHLSYDPT------TNAIAYPCGKS-AFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKF 72 HL+ P TN + G S + + DD S+ +VQ H S + +K+ Sbjct: 242 TRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKY 301 Query: 73 SPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLC 132 P S E V +W + + + L + Sbjct: 302 FP--DGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVH------PSQNYFCA 353 Query: 133 VVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVF-YQGP 191 + R + GHS L S R + GD S +F + Sbjct: 354 QSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWN 413 Query: 192 PFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFD 235 + + + + V++ P VI G+ KI D Sbjct: 414 TSRLLNNIK--IPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 Score = 29.1 bits (63), Expect = 5.6, Method: Composition-based stats. Identities = 11/81 (13%), Positives = 26/81 (32%), Gaps = 11/81 (13%) Query: 492 SYISISP-SETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEE 550 + + P + I +G I ++D + H I A+ + + Sbjct: 166 TALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQS----- 220 Query: 551 IEEDLVATGSLDTNIFIYSVK 571 + S D ++ I+ + Sbjct: 221 -----FLSSSFDRSVKIWDTE 236 >3C9C-A nrPDB Length = 432 Score = 83.0 bits (203), Expect = 3e-16, Method: Composition-based stats. Identities = 37/226 (16%), Positives = 75/226 (33%), Gaps = 17/226 (7%) Query: 162 RINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEF 221 NAC + P + V D + + P D + ++P+ + Sbjct: 140 PQNACVIATKTPSSDVLV-FDYTKHPSKPEPSGECQPDLRLRGHQKEGYGLSWNPNLNGY 198 Query: 222 VITVGSDRKISCFDGKSGEFL-------KYIEDDQEPVQGGIFALSWLDSQKFATVGADA 274 +++ D I +D + V+ + L L F +V D Sbjct: 199 LLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHL--LHESLFGSVADDQ 256 Query: 275 TIRVWDVTTSKCVQ-KWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEV-L 332 + +WD + + T+D + + + S D T+ ++L + ++ L Sbjct: 257 KLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKL 316 Query: 333 KTISGHNKGITALTVNP-----LISGSYDGRIMEWSSSSMHQDHSN 373 + H I + +P L S D R+ W S + ++ S Sbjct: 317 HSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQST 362 Score = 81.1 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 48/319 (15%), Positives = 100/319 (31%), Gaps = 57/319 (17%) Query: 62 HGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQ--VLAGPI 119 H V ++ P + + + + S V+V+ +T + + + Sbjct: 129 HEGEV-NRARYMP-QNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEG 186 Query: 120 SDISWDFE-GRRLCVVGEGRDNFGVFISWDSGNSLG---------EVSGHSQRINACHLK 169 +SW+ L + WD + +GH+ + Sbjct: 187 YGLSWNPNLNGYLLSASDDH----TICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWH 242 Query: 170 QSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDR 229 +V DD ++ + S T + V + F+P S + T +D+ Sbjct: 243 LLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADK 302 Query: 230 KISCFDGKSGEF-LKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQ 288 ++ +D ++ + L E ++ + ++ + A+ G D + VWD++ Sbjct: 303 TVALWDLRNLKLKLHSFESHKDEIFQVQWSP--HNETILASSGTDRRLHVWDLSK----- 355 Query: 289 KWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVN 348 +G +Q A E+L GH I+ + N Sbjct: 356 --------IGEEQSTEDAEDGP------------------PELLFIHGGHTAKISDFSWN 389 Query: 349 P-----LISGSYDGRIMEW 362 P + S S D + W Sbjct: 390 PNEPWIICSVSEDNIMQVW 408 Score = 58.4 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 46/299 (15%), Positives = 97/299 (32%), Gaps = 88/299 (29%) Query: 335 ISGHNKGITALTVNP-----LISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSI 389 + GH K L+ NP L+S S D I W ++ ++H + A+ + Sbjct: 179 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVI-------DAKNIFT- 230 Query: 390 SWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPG 449 T V + H + + +D L+I + + K Sbjct: 231 --GHTAVVEDVAWHLLH----------ESLFGSVADDQKLMIWDTRNNNTSKP------- 271 Query: 450 SAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAA-GDV 508 + D T A+ + +S +P +I A G Sbjct: 272 ----------------------------SHTVDAHT---AEVNCLSFNPYSEFILATGSA 300 Query: 509 MGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIY 568 + L+DL++ ++K + H +I + W P E ++A+ D + ++ Sbjct: 301 DKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP---------HNETILASSGTDRRLHVW 351 Query: 569 SVKR-------------PMKIIKALNAHKDGVNNLLWE-TPSTLVSS-GADACIKRWNV 612 + + P +++ H +++ W ++ S D ++ W + Sbjct: 352 DLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 410 Score = 52.6 bits (124), Expect = 5e-07, Method: Composition-based stats. Identities = 36/289 (12%), Positives = 71/289 (24%), Gaps = 83/289 (28%) Query: 18 RNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPV------VQFTGHGSSVVTTVK 71 +N + P+++ V SK P ++ GH Sbjct: 141 QNACVIATKTPSSD---------VLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY---G 188 Query: 72 FSPIKG-SQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRR 130 S + YL S + + +W + + V ++ K+ F + D++W Sbjct: 189 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRV-IDAKNIFTGHTAVVEDVAWHLLHES 247 Query: 131 LCVVGEGRDNFGVFISWDSGNSLG-----EVSGHSQRINACHLKQSRPMRSMTVGDDGSV 185 L + WD+ N+ V H+ +N T D +V Sbjct: 248 LFGSVADDQK---LMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTV 304 Query: 186 VF------------------------YQGPPFKFSASDRT-------------------- 201 + AS T Sbjct: 305 ALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTED 364 Query: 202 -----------HHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSG 239 H + + D ++P+ + +V D + + Sbjct: 365 AEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 413 Score = 31.8 bits (70), Expect = 0.99, Method: Composition-based stats. Identities = 13/75 (17%), Positives = 25/75 (33%), Gaps = 3/75 (4%) Query: 44 RCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQY-LCSGDESGKVIVWGWTFDKESN 102 + +D + P ++ HG FS + +CS E + VW + ++ Sbjct: 360 QSTEDAEDGPPELLFI--HGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENVYND 417 Query: 103 SVEVNVKSEFQVLAG 117 SE + Sbjct: 418 EEPEIPASELETNTA 432 >5WBU-D nrPDB Length = 328 Score = 82.3 bits (201), Expect = 5e-16, Method: Composition-based stats. Identities = 47/305 (15%), Positives = 106/305 (34%), Gaps = 31/305 (10%) Query: 62 HGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISD 121 H S V ++ +P + S +G + + ++ + + + + + I+ Sbjct: 42 HQDSQVNALEVTPDR-SMIAAAGYQH--IRMYDLNSNNPNPIIS------YDGVNKNIAS 92 Query: 122 ISWDFEGRRLCVVGEGRDNFGVFISWDSGNSL---GEVSGHSQRINACHLKQSRPMRSMT 178 + + +GR + GE WD + + + IN L ++ + Sbjct: 93 VGFHEDGRWMYTGGED----CTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIV- 147 Query: 179 VGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKS 238 G++ + K +++ + + PD+ ++ V S ++ Sbjct: 148 GDQSGAIHIWDL---KTDHNEQLIPEPEVSITSAHIDPDA-SYMAAVNSTGNCYVWNLTG 203 Query: 239 G---EFLKYIEDDQEPVQG--GIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLD 293 G E + I + P + DS AT AD T ++W + + + ++ Sbjct: 204 GIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIK 263 Query: 294 KQQLG----NQQVGVVATGNGR-IISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVN 348 G G +G+ + I++ S D + + E+ + GH K + L N Sbjct: 264 SGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 323 Query: 349 PLISG 353 + G Sbjct: 324 DSVLG 328 Score = 82.3 bits (201), Expect = 7e-16, Method: Composition-based stats. Identities = 55/302 (18%), Positives = 101/302 (33%), Gaps = 27/302 (8%) Query: 171 SRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRK 230 S P+ T G D +V F+Q RT Q S V +E +PD +I + Sbjct: 12 SDPVILATAGYDHTVRFWQAHS---GICTRTVQHQDSQVNALEVTPDRS--MIAAAGYQH 66 Query: 231 ISCFDGKSGEFLKYIEDDQEPVQGGIFALSWL-DSQKFATVGADATIRVWDVTTS--KCV 287 I +D S I + V I ++ + D + T G D T R+WD+ + +C Sbjct: 67 IRMYDLNSNNPNPIIS--YDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQ 124 Query: 288 QKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTV 347 + + + + +I G ++ ++L D + I IT+ + Sbjct: 125 RIFQV----NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHI 180 Query: 348 NPLIS----GSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKH 403 +P S + G W+ + D ++ A ++ + + Sbjct: 181 DPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATC 240 Query: 404 EFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGL 463 K+ +N L +G+ +S R G A S Y+ Sbjct: 241 SADQTCKIWRTSNFSLMTEL---------SIKSGNPGESSRGWMWGCAFSGDSQYIVTAS 291 Query: 464 EE 465 + Sbjct: 292 SD 293 Score = 81.5 bits (199), Expect = 1e-15, Method: Composition-based stats. Identities = 44/264 (16%), Positives = 92/264 (34%), Gaps = 28/264 (10%) Query: 42 FVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKES 101 +R D + P++ + G + + +V F + +++ +G E +W + Sbjct: 66 HIRMYDLNSNNPNPIISYDG-VNKNIASVGFH--EDGRWMYTGGEDCTARIW------DL 116 Query: 102 NSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWD--SGNSLGEVSGH 159 S + + FQV PI+ + L V D G WD + ++ + Sbjct: 117 RSRNLQCQRIFQV-NAPINCVCLHPNQAELIVG----DQSGAIHIWDLKTDHNEQLIPEP 171 Query: 160 SQRINACHLKQSRPMRSMTVGDDGSVVFYQ-----GPPFKFSASDRTHHKQGSFVRDVEF 214 I + H+ + V G+ + G + F Sbjct: 172 EVSITSAHIDPDASYMA-AVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRF 230 Query: 215 SPDSGEFVITVGSDRKISCFDGKSGEFLKYIE----DDQEPVQGGIFALSWL-DSQKFAT 269 SPDS + T +D+ + + + + + E +G ++ ++ DSQ T Sbjct: 231 SPDST-LLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVT 289 Query: 270 VGADATIRVWDVTTSKCVQKWTLD 293 +D R+W V T + +++ Sbjct: 290 ASSDNLARLWCVETGEIKREYGGH 313 Score = 60.3 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 51/318 (16%), Positives = 104/318 (32%), Gaps = 50/318 (15%) Query: 312 IISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSM 367 + + D T+ F++ +T+ + + AL V P + + Y I + +S Sbjct: 17 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSN 75 Query: 368 HQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDD 427 + N I+S D + +S+ F + + TA Sbjct: 76 NP---NPIISYD-GVNKNIASV--------------GFHEDGRWMYTGGEDCTA------ 111 Query: 428 DLLILQSFTGDI----IKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDL 483 I + ++ I V + +Q + VG + G I ++ L + Sbjct: 112 --RIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSG-AIHIWDLKTDHNEQLI 168 Query: 484 KTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKI-NAISWKPA 542 P + I P +Y+AA + G +++L +KI + Sbjct: 169 PEP-EVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQ 227 Query: 543 EKGANEEEIEEDLVATGSLDTNIFIY-----SVKRPMKIIKALNAHKDG--VNNLLWETP 595 + + + L+AT S D I+ S+ + I + + Sbjct: 228 CRFSP----DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGD 283 Query: 596 ST-LVSSGADACIKRWNV 612 S +V++ +D + W V Sbjct: 284 SQYIVTASSDNLARLWCV 301 Score = 59.2 bits (141), Expect = 5e-09, Method: Composition-based stats. Identities = 47/323 (14%), Positives = 104/323 (32%), Gaps = 55/323 (17%) Query: 267 FATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYEL 326 AT G D T+R W + C + Q +Q + T + +I+ + + Y+L Sbjct: 17 LATAGYDHTVRFWQAHSGICTRT----VQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDL 72 Query: 327 GH--DEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSS-------------- 366 + + G NK I ++ + + +G D W S Sbjct: 73 NSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAP 132 Query: 367 -----MHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTA 421 +H + + LIV + + + D ++ + S A+ + A Sbjct: 133 INCVCLHPNQAELIVGDQSGAIHIW-DLKTDHNEQLIPEPEVSITSAHIDPDAS---YMA 188 Query: 422 VLTNDDDLLILQSFTG------------DIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTI 469 + + + + G I R S +A + T Sbjct: 189 AVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCR-FSPDSTLLATCSAD-QTC 246 Query: 470 QVFKLSDLEVSFDLK----TPLRAKPSYI---SISPSETYIAAGDVMGKILLYDLQSREV 522 ++++ S+ + +L P + ++ + S YI L+ +++ E+ Sbjct: 247 KIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEI 306 Query: 523 KTSRWAFHTSKINAISWKPAEKG 545 K + H + +++ + G Sbjct: 307 K-REYGGHQKAVVCLAFNDSVLG 328 >5Y1U-A nrPDB Length = 456 Score = 82.3 bits (201), Expect = 7e-16, Method: Composition-based stats. Identities = 48/311 (15%), Positives = 95/311 (30%), Gaps = 53/311 (17%) Query: 85 DESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFE-GRRLCVVGEGRDNFGV 143 V + K S E N + +SW+ L + Sbjct: 177 SSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDH----T 232 Query: 144 FISWD------SGNSL---GEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFK 194 WD G + +GH+ + +V DD ++ + Sbjct: 233 ICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNN 292 Query: 195 FSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEF-LKYIEDDQEPVQ 253 S + + V + F+P S + T +D+ ++ +D ++ + L E ++ + Sbjct: 293 TSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIF 352 Query: 254 GGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRII 313 ++ + A+ G D + VWD++ +G +Q A Sbjct: 353 QVQWSP--HNETILASSGTDRRLNVWDLSK-------------IGEEQSPEDAEDGP--- 394 Query: 314 SLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP-----LISGSYDGRIMEWSSSSMH 368 E+L GH I+ + NP + S S D + W + Sbjct: 395 ---------------PELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENI 439 Query: 369 QDHSNLIVSLD 379 + + S+D Sbjct: 440 YNDEDPEGSVD 450 Score = 80.0 bits (195), Expect = 3e-15, Method: Composition-based stats. Identities = 48/318 (15%), Positives = 96/318 (30%), Gaps = 42/318 (13%) Query: 93 WGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFIS---WDS 149 W + V +F + + E L + N +DS Sbjct: 73 WPSLTAQWLPDVTRPEGKDFSIHR-LVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDS 131 Query: 150 GNS----LGEVSG---------HSQRINACHLKQSRPMRSMTVGDDGSVVFYQ------- 189 G VSG H +N P T V+ + Sbjct: 132 EKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSK 191 Query: 190 -GPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKS----GEFL-- 242 P + + D + ++P+ +++ D I +D + G+ + Sbjct: 192 PDPSGECN-PDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDA 250 Query: 243 -KYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQ-KWTLDKQQLGNQ 300 V+ + L L F +V D + +WD ++ + ++D Sbjct: 251 KTIFTGHTAVVEDVSWHL--LHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVN 308 Query: 301 QVGVVATGNGRIISLSLDGTLNFYELGHDEV-LKTISGHNKGITALTVNP-----LISGS 354 + + + S D T+ ++L + ++ L + H I + +P L S Sbjct: 309 CLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSG 368 Query: 355 YDGRIMEWSSSSMHQDHS 372 D R+ W S + ++ S Sbjct: 369 TDRRLNVWDLSKIGEEQS 386 Score = 56.1 bits (133), Expect = 5e-08, Method: Composition-based stats. Identities = 47/299 (15%), Positives = 99/299 (33%), Gaps = 88/299 (29%) Query: 335 ISGHNKGITALTVNP-----LISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSI 389 + GH K L+ NP L+S S D I W S++ ++ + + +I Sbjct: 204 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVV----------DAKTI 253 Query: 390 SWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPG 449 T V ++ H + + +D L+I + + + K Sbjct: 254 FTGHTAVVEDVSWHLLH----------ESLFGSVADDQKLMIWDTRSNNTSKP------- 296 Query: 450 SAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAA-GDV 508 S D T A+ + +S +P +I A G Sbjct: 297 ----------------------------SHSVDAHT---AEVNCLSFNPYSEFILATGSA 325 Query: 509 MGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIY 568 + L+DL++ ++K + H +I + W P E ++A+ D + ++ Sbjct: 326 DKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP---------HNETILASSGTDRRLNVW 376 Query: 569 SVKR-------------PMKIIKALNAHKDGVNNLLWE-TPSTLVSS-GADACIKRWNV 612 + + P +++ H +++ W ++ S D ++ W + Sbjct: 377 DLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 435 Score = 54.2 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 35/283 (12%), Positives = 75/283 (26%), Gaps = 71/283 (25%) Query: 18 RNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKG 77 +N + P+++ + + K D + P ++ GH S Sbjct: 166 QNPCIIATKTPSSDVLVFDYTKHP---SKPDPSGECNPDLRLRGHQKEGY---GLSWNPN 219 Query: 78 -SQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGE 136 S +L S + + +W + + V V+ K+ F + D+SW L Sbjct: 220 LSGHLLSASDDHTICLWDISAVPKEGKV-VDAKTIFTGHTAVVEDVSWHLLHESLFGSVA 278 Query: 137 GRDNFGVFISWDSGNSLGE-----VSGHSQRINACHLKQSRPMRSMTVGDDGSVVFY--- 188 + WD+ ++ V H+ +N T D +V + Sbjct: 279 DDQK---LMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 335 Query: 189 -------------------------------QGPPFKFSASDRT---------------- 201 G + + D + Sbjct: 336 NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPP 395 Query: 202 -----HHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSG 239 H + + D ++P+ + +V D + + Sbjct: 396 ELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 438 >3CFV-B nrPDB Length = 414 Score = 81.9 bits (200), Expect = 8e-16, Method: Composition-based stats. Identities = 47/294 (15%), Positives = 88/294 (29%), Gaps = 53/294 (18%) Query: 85 DESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFE-GRRLCVVGEGRDNFGV 143 V + K S E N + +SW+ L + Sbjct: 148 SSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDH----T 203 Query: 144 FISWD------SGNSL---GEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFK 194 WD G + +GHS + +V DD ++ + Sbjct: 204 VCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNT 263 Query: 195 FSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEF-LKYIEDDQEPVQ 253 S + V + F+P S + T +D+ ++ +D ++ + L E ++ + Sbjct: 264 TSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIF 323 Query: 254 GGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRII 313 ++ + A+ G D + VWD++ +G +Q A Sbjct: 324 QVHWSP--HNETILASSGTDRRLNVWDLSK-------------IGEEQSAEDAEDGP--- 365 Query: 314 SLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP-----LISGSYDGRIMEW 362 E+L GH I+ + NP + S S D + W Sbjct: 366 ---------------PELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIW 404 Score = 54.9 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 53/407 (13%), Positives = 112/407 (27%), Gaps = 116/407 (28%) Query: 197 ASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGI 256 + + D GEF KI C + + + V Sbjct: 83 VARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIEC---------EIKINHEGEVNRAR 133 Query: 257 FALSWLDSQKFATVGADATIRVWDV--------TTSKCVQKWTLDKQQLGNQQVGVVATG 308 + AT + + V+D + +C L Q + + Sbjct: 134 YMPQNP--HIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNL 191 Query: 309 NGRIISLSLDGTLNFYELGHD-------EVLKTISGHNKGITALTVNPLI-----SGSYD 356 +G ++S S D T+ +++ + +GH+ + + + L S + D Sbjct: 192 SGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADD 251 Query: 357 GRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANN 416 ++M W + S + S L + H + + Sbjct: 252 QKLMIWDTRSN--------------------TTSKPSHL----VDAHTAEVNCLSFNPYS 287 Query: 417 DGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSD 476 + A + D + + + + F+ Sbjct: 288 EFILATGSADKTVALWDLRNLKL----------------------------KLHTFESHK 319 Query: 477 LEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSR---------- 526 E+ +P +ET +A+ ++ ++DL + S Sbjct: 320 DEIFQVHWSP-----------HNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPEL 368 Query: 527 ---WAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSV 570 HT+KI+ SW P E ++ + S D + I+ + Sbjct: 369 LFIHGGHTAKISDFSWNPNEPW---------VICSVSEDNIMQIWQM 406 Score = 53.8 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 42/312 (13%), Positives = 99/312 (31%), Gaps = 44/312 (14%) Query: 327 GHDEVLKTIS-GHNKGITALTVNP-------LISGSYDGRIMEWSSSSMHQDHSNLIVS- 377 ++ I H + P + S D + +++ D S Sbjct: 113 VTGKIECEIKINHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPD 172 Query: 378 -LDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFT 436 +E +SW+ L + ++ + + N + + + S Sbjct: 173 LRLRGHQKEGYGLSWNSNLSGHLLSASD-DHTVCLWDINAGPKEGKIVDAKAIFTGHSAV 231 Query: 437 GDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISI 496 + + L+ + + NT S D T A+ + +S Sbjct: 232 VEDVAWHLLHESLFGSVADDQKLMIWDTRSNT-----TSKPSHLVDAHT---AEVNCLSF 283 Query: 497 SPSETYIAA-GDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDL 555 +P +I A G + L+DL++ ++K + H +I + W P E + Sbjct: 284 NPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSP---------HNETI 334 Query: 556 VATGSLDTNIFIYSVKR-------------PMKIIKALNAHKDGVNNLLWE-TPSTLVSS 601 +A+ D + ++ + + P +++ H +++ W ++ S Sbjct: 335 LASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICS 394 Query: 602 -GADACIKRWNV 612 D ++ W + Sbjct: 395 VSEDNIMQIWQM 406 Score = 53.8 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 31/253 (12%), Positives = 65/253 (25%), Gaps = 68/253 (26%) Query: 48 DGDSKVPPVVQFTGHGSSVVTTVKFSPIKG-SQYLCSGDESGKVIVWGWTFDKESNSVEV 106 D + P ++ GH S S +L S + V +W + + V Sbjct: 164 DPSGECNPDLRLRGHQKEGY---GLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKI-V 219 Query: 107 NVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGE-----VSGHSQ 161 + K+ F + + D++W L + WD+ ++ V H+ Sbjct: 220 DAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQK---LMIWDTRSNTTSKPSHLVDAHTA 276 Query: 162 RINACHLKQSRPMRSMTVGDDGSVVFY--------------------------------- 188 +N T D +V + Sbjct: 277 EVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILA 336 Query: 189 -QGPPFKFSASDRT---------------------HHKQGSFVRDVEFSPDSGEFVITVG 226 G + + D + H + + D ++P+ + +V Sbjct: 337 SSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVS 396 Query: 227 SDRKISCFDGKSG 239 D + + Sbjct: 397 EDNIMQIWQMAEN 409 >4L9O-A nrPDB Length = 349 Score = 80.4 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 40/263 (15%), Positives = 86/263 (32%), Gaps = 24/263 (9%) Query: 78 SQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEG 137 + L + + ++ + + + GP+ ++W + + Sbjct: 81 GRRLATCSSDKTIKIFEIDGENQR------LVETLIGHEGPVWQVAWAHPKFGVILASCS 134 Query: 138 RDNFGVFISWDSG--NSLGEVSGHSQRINACHLKQS--RPMRSMTVGDDGSVVFYQGPPF 193 D + D+G N + E S H +N+ P+ DG + + Sbjct: 135 YDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLC-ASSDGKISIVEFKDG 193 Query: 194 KFSASDRTHHKQGSFVRDVEFSP----DSGEFVITVGSDRKISCF--DGKSGEFL--KYI 245 V ++P D+ ++ G D + + D + F+ + Sbjct: 194 GALEPI-VIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAF 252 Query: 246 EDDQEPVQGGIFALSWLDSQKFATVGADATIRVW--DVTTSK-CVQKWTLDKQQLGNQQV 302 + + V+ ++ S L AT D T+ +W D ++K Q T +K + Sbjct: 253 QGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVCWRA 312 Query: 303 GVVATGNGRIISLSLDGTLNFYE 325 +GN IS D + ++ Sbjct: 313 SWSLSGNVLAISGG-DNKVTLWK 334 Score = 60.7 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 44/277 (15%), Positives = 102/277 (36%), Gaps = 35/277 (12%) Query: 309 NGRIISLSLDGTLNFYEL--GHDEVLKTISGHNKGITALT-VNP-----LISGSYDGRIM 360 R+ + S D T+ +E+ + +++T+ GH + + +P L S SYDG+++ Sbjct: 81 GRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVL 140 Query: 361 EWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFT 420 W + + V+ + +S+SW P + A++DG Sbjct: 141 IWKEDNGVWNK----VAEHSVHQASVNSVSWAPH-----------EYGPVLLCASSDGKI 185 Query: 421 AVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVS 480 +++ D + V S V N +++++ D + Sbjct: 186 SIVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKT 245 Query: 481 FDLKTPLRAKPSYI---SISPS---ETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKI 534 F + + ++ + SPS ++YIA +L++ +++ K+++W + Sbjct: 246 FIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIW---TKDGKSNKW--EKQPL 300 Query: 535 NAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVK 571 + A+ L +G D + ++ Sbjct: 301 TKEKFPDVCWRASWSLSGNVLAISGG-DNKVTLWKEN 336 Score = 41.1 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 25/165 (15%), Positives = 50/165 (30%), Gaps = 22/165 (13%) Query: 38 GKSAFVRCLDDGDSKVPPVVQFTGH--GSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGW 95 GK + V D G + + GH G + + S ++ SG V +W + Sbjct: 183 GKISIVEFKDGGALEP---IVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRY 239 Query: 96 TFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGE 155 + + + FQ + + D++W + + V I G S Sbjct: 240 ----DDAAKTFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKW 295 Query: 156 VSGHSQRINA---------CHLKQSRPMRSMTVGDDGSVVFYQGP 191 Q + S + +++ D V ++ Sbjct: 296 ---EKQPLTKEKFPDVCWRASWSLSGNVLAISG-GDNKVTLWKEN 336 >4A11-B nrPDB Length = 408 Score = 80.4 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 49/329 (14%), Positives = 104/329 (31%), Gaps = 31/329 (9%) Query: 62 HGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESN-----SVEVNVKSEFQVLA 116 HG + T + P++G +Y+ SG G ++++ + +V + V Sbjct: 42 HGGGINT-LDIEPVEG-RYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHR 99 Query: 117 GPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGN-SLGEVSGHSQRINACHLKQSRPMR 175 + + W + WD+ +V + + + H+ Sbjct: 100 YSVETVQWYPHDTGMFTSSS---FDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKH 156 Query: 176 SMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFD 235 + Q K + + V +SP + T +D ++ +D Sbjct: 157 CLVAVGTRGPKV-QLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWD 215 Query: 236 GK------------SGEFLKYIEDDQEPVQGGIFALSW-LDSQKFATVGADATIRVWDVT 282 + +G+ + +E G + L + D TVG D +R+W+ + Sbjct: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 Query: 283 TSKCVQKWTLDKQQLGNQQVGVVAT--GNGRIISLSLDGTLNFYELGHDEVLKTISGHNK 340 + + + + + + + T+ Y + E + + GH K Sbjct: 276 NGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYK 335 Query: 341 GITALTVNP----LISGSYDGRIMEWSSS 365 + L SGS D I+ W S Sbjct: 336 TVDCCVFQSNFQELYSGSRDCNILAWVPS 364 Score = 48.4 bits (113), Expect = 8e-06, Method: Composition-based stats. Identities = 28/271 (10%), Positives = 84/271 (30%), Gaps = 34/271 (12%) Query: 272 ADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEV 331 A++T RV + +K + G + + ++S DG + Y+L + Sbjct: 21 AESTRRVLGLELNKDRDVERIHGG--GINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSR 78 Query: 332 LKTIS-------------GHNKGITALTVNP-----LISGSYDGRIMEWSSSSMHQDHSN 373 + H + + P S S+D + W ++++ ++ Sbjct: 79 QSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQT--AD 136 Query: 374 LIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLI-- 431 + + + S +S L G + ++ + + +L ++ Sbjct: 137 VFNFEETVYSHHMSPVSTKHCLVAVGTRGPKV----QLCDLKSGSCSHILQGHRQEILAV 192 Query: 432 -LQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAK 490 I+ + +S + + + + + + + + T K Sbjct: 193 SWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESA-----NTAHNGK 247 Query: 491 PSYISISPSETYIAAGDVMGKILLYDLQSRE 521 + + + ++ ++ L++ + E Sbjct: 248 VNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE 278 >5WLC-LJ nrPDB Length = 513 Score = 80.0 bits (195), Expect = 3e-15, Method: Composition-based stats. Identities = 44/266 (16%), Positives = 90/266 (33%), Gaps = 21/266 (7%) Query: 63 GSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDI 122 + VT + F+P + + ++ +S V F + Sbjct: 38 EHNSVTHISFNPQHPHDFAVTSSTRVQI----------FSSRTRQVIKTFSRFKDVVYSA 87 Query: 123 SWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDD 182 S+ +G+ LC G+ V+ S++ L ++ + + T DD Sbjct: 88 SFRSDGKLLC-AGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFHTQDNKILATASDD 146 Query: 183 GSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGK-SGEF 241 + +VR + F P + V T D I +D + SG Sbjct: 147 RVTRLWDIS--NAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTRSSGST 204 Query: 242 LKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQ 301 Y + +PV+ I + + G + +VWD+T++K + + + + Sbjct: 205 PIYSLNHDQPVENVIAVSP----TQIVSCGGNNF-KVWDLTSNKKLYERGNFNKAVTCLD 259 Query: 302 V--GVVATGNGRIISLSLDGTLNFYE 325 + +I+ SLDG + ++ Sbjct: 260 YVENFDSPMQSALIASSLDGHVKVFD 285 Score = 66.9 bits (161), Expect = 3e-11, Method: Composition-based stats. Identities = 38/265 (14%), Positives = 89/265 (33%), Gaps = 17/265 (6%) Query: 204 KQGSFVRDVEFSP-DSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWL 262 K+ + V + F+P +F +T + ++ F ++ + +K ++ V F Sbjct: 37 KEHNSVTHISFNPQHPHDFAVTSST--RVQIFSSRTRQVIKTFSRFKDVVYSASF---RS 91 Query: 263 DSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLN 322 D + A + V+D + + +++ N + + S D Sbjct: 92 DGKLLCAGDATGLVSVYDSYNPRTI-LLSINASTHPTHVTKFHTQDNKILATASDDRVTR 150 Query: 323 FYELGHD-EVLKTISGHNKGITALTV-----NPLISGSYDGRIMEWSSSSMHQDHSNLIV 376 +++ + E ++G + L+ + + +GSYDG I + + S I Sbjct: 151 LWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDT---RSSGSTPIY 207 Query: 377 SLDN-SKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSF 435 SL++ + ++S + G + F +T D + S Sbjct: 208 SLNHDQPVENVIAVSPTQIVSCGGNNFKVWDLTSNKKLYERGNFNKAVTCLDYVENFDSP 267 Query: 436 TGDIIKSVRLNSPGSAVSLSQNYVA 460 + + L+ N+ Sbjct: 268 MQSALIASSLDGHVKVFDPLDNFQV 292 Score = 36.8 bits (83), Expect = 0.031, Method: Composition-based stats. Identities = 20/127 (15%), Positives = 49/127 (38%), Gaps = 13/127 (10%) Query: 488 RAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGAN 547 ++IS +P + A ++ ++ ++R+V ++ + + S++ K Sbjct: 39 HNSVTHISFNPQHPHDFAVTSSTRVQIFSSRTRQV-IKTFSRFKDVVYSASFRSDGK--- 94 Query: 548 EEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNA--HKDGVNNLLWETPSTLVSSGADA 605 L+ G + +Y P I+ ++NA H V + L ++ D Sbjct: 95 -------LLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFHTQDNKILATASDDR 147 Query: 606 CIKRWNV 612 + W++ Sbjct: 148 VTRLWDI 154 Score = 34.9 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 23/160 (14%), Positives = 44/160 (27%), Gaps = 15/160 (9%) Query: 17 QRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIK 76 ++ LS+ P + +R D S P+ H V + SP + Sbjct: 167 ATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTRSSGSTPIYSLN-HDQPVENVIAVSPTQ 225 Query: 77 GSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGE 136 VW T +K+ N L + + + + + Sbjct: 226 -----IVSCGGNNFKVWDLTSNKKLYE-RGNFNKAVTCLD-YVENFDSPMQSALIASSLD 278 Query: 137 GRDNFGVFISWDSGNSLGEVSG--HSQRINACHLKQSRPM 174 G +D ++ G S + +C + S Sbjct: 279 GH-----VKVFDPLDNFQVKFGWKFSGPVLSCAVSPSTAQ 313 >5WYJ-BE nrPDB Length = 939 Score = 79.2 bits (193), Expect = 5e-15, Method: Composition-based stats. Identities = 67/418 (16%), Positives = 135/418 (32%), Gaps = 92/418 (22%) Query: 77 GSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGE 136 GS +L G SG +I +D + S +K+ + G ++ ++ + G Sbjct: 260 GSSHLSVGTSSGDLI----FYDLDRRSRIHVLKNIHRESYGGVTQATFLNGQPIIVTSGG 315 Query: 137 GRDNFGVFI--SWDSGNS---------LGEVSGHSQRINACHLKQSRPMRSMTVGDDGSV 185 S G+ L GHSQ + S+ ++ D S+ Sbjct: 316 DNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPSYIAFADSQSHFMLSASKDRSL 375 Query: 186 VFYQ--GPPFKFSASDRTHHKQ-----------GSFVRDVEFSPDSGEF-----VITVGS 227 + S R H KQ F V + ++ +IT Sbjct: 376 WSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFPEIVALAIENARIGEWENIITAHK 435 Query: 228 D-RKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFA-TVGADATIRVWDVTTSK 285 D + +D ++ ++ D + G + +++ F ++ +I ++++ + Sbjct: 436 DEKFARTWDMRNKRVGRWTFDTTDD--GFVKSVAMSQCGNFGFIGSSNGSITIYNMQSGI 493 Query: 286 CVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYEL------------------- 326 +K+ L K+ + + N +++S LDG + FY+ Sbjct: 494 LRKKYKLHKRAVTGISLD---GMNRKMVSCGLDGIVGFYDFNKSTLLGKLKLDAPITAMV 550 Query: 327 ----------------------GHDEVLKTISGHNKGITALTVNP----LISGSYDGRIM 360 V++ + GH+ ITA +P ++S S D I Sbjct: 551 YHRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIR 610 Query: 361 EWSSSSMHQDH----SNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASA 414 W + N+ ++ S + + + + NGI +Q K S Sbjct: 611 TWDLPTGGCIDGIIVDNVATNVKFSPNGDLLATT---HVTGNGICIWTNRAQFKTVST 665 Score = 54.2 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 77/529 (14%), Positives = 173/529 (32%), Gaps = 65/529 (12%) Query: 73 SPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGP--ISDISWDFEGRR 130 YLC+ + + ++ + ++ E K + G +S + Sbjct: 120 HLCIFGDYLCASTDDNSIFIYKKSDPQDKYPSEFYTKLTVTEIQGGEIVSLQHLATYLNK 179 Query: 131 LCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDD--GSVVFY 188 L VV + + + + +G + ++ + + P+ + G V+ + Sbjct: 180 LTVVTK---SNVLLFNVRTGKLVFT---SNEFPDQITTAEPAPVLDIIALGTVTGEVIMF 233 Query: 189 QGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDD 248 K RT S + + F D + S + +D + +++ Sbjct: 234 NMRKGK---RIRTIKIPQSRISSLSFRTDGSSHLSVGTSSGDLIFYDLDRRSRIHVLKNI 290 Query: 249 QEPVQGGIFALSWLDSQKF-ATVGADATIR--VWDVTTSK---------CVQKWTLDKQQ 296 GG+ ++L+ Q T G D +++ V+D + S+ + Sbjct: 291 HRESYGGVTQATFLNGQPIIVTSGGDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHS 350 Query: 297 LGNQQVGVVATGNGRIISLSLDGTLNFY------ELGHDEVLKTISGHNKGITALTVNPL 350 + + + ++S S D + + + E+ + + G + + + Sbjct: 351 QPPSYIAFADSQSHFMLSASKDRS--LWSFSLRKDAQSQEMSQRLHKKQDGGR-VGGSTI 407 Query: 351 ISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNG-----ITKHEF 405 S + + ++ ++ + E + +WD K G T F Sbjct: 408 KSKFPEIV-----ALAIENARIGEWENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGF 462 Query: 406 GSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSA-VSLS--QNYVAVG 462 ++ N GF + I +G + K +L+ +SL + Sbjct: 463 VKSVAMSQCGNFGFIGSSNG--SITIYNMQSGILRKKYKLHKRAVTGISLDGMNRKMVSC 520 Query: 463 LEEGNTI-QVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSRE 521 +G F S L L P+ A + S S+ + A D I++ D ++ Sbjct: 521 GLDGIVGFYDFNKSTLLGKLKLDAPITAMVYHRS---SDLFALALD-DLSIVVIDAVTQR 576 Query: 522 VKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSV 570 V W H+++I A + P + + + SLD+ I + + Sbjct: 577 VVRQLW-GHSNRITAFDFSPEGRW----------IVSASLDSTIRTWDL 614 Score = 32.2 bits (71), Expect = 0.60, Method: Composition-based stats. Identities = 14/128 (10%), Positives = 35/128 (27%), Gaps = 15/128 (11%) Query: 56 VVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVL 115 V Q GH + + F +++ S + W + + V+ + Sbjct: 578 VRQLWGHSNRIT---AFDFSPEGRWIVSASLDSTIRTWDLPTGGCIDGIIVDNVAT---- 630 Query: 116 AGPISDISWDFEGRRLC---VVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSR 172 ++ + G L V G G + + + ++ R+ Sbjct: 631 -----NVKFSPNGDLLATTHVTGNGICIWTNRAQFKTVSTRTIDESEFARMALPSTSVRG 685 Query: 173 PMRSMTVG 180 ++ Sbjct: 686 NDSMLSGA 693 >2HES-X nrPDB Length = 330 Score = 78.8 bits (192), Expect = 7e-15, Method: Composition-based stats. Identities = 42/287 (14%), Positives = 98/287 (34%), Gaps = 27/287 (9%) Query: 56 VVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVL 115 V+ T H ++ + + L +G V +W + E+++ + + Sbjct: 51 VLDETAHKKAIRSVA---WRPHTSLLAAGSFDSTVSIWAKEESADRT-FEMDLLAIIEGH 106 Query: 116 AGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGN------SLGEVSGHSQRINACHLK 169 + ++W +G L + W++ + + HSQ + Sbjct: 107 ENEVKGVAWSNDGYYLATCSRDKS----VWIWETDESGEEYECISVLQEHSQDVKHVIWH 162 Query: 170 QSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEF-VITVGSD 228 S + + + D +V ++ + + V +F G F + + D Sbjct: 163 PSEALLA-SSSYDDTVRIWKDYDDDW-ECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDD 220 Query: 229 RKISCF----DGKSGEFLKYIEDDQEPVQG-GIFALSWLDSQKFATVGADATIRVWDVTT 283 + + D + + E V ++ ++W + A+VGAD + V++ Sbjct: 221 STVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNGLIASVGADGVLAVYEEVD 280 Query: 284 SKCVQKWTLDKQQLGNQQVGVVA----TGNGRIISLSLDGTLNFYEL 326 + + + G ++ VV G + + DG +NF+ L Sbjct: 281 GE-WKVFAKRALCHGVYEINVVKWLELNGKTILATGGDDGIVNFWSL 326 Score = 78.4 bits (191), Expect = 8e-15, Method: Composition-based stats. Identities = 41/270 (15%), Positives = 88/270 (32%), Gaps = 30/270 (11%) Query: 123 SWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEV--SGHSQRINACHLKQSRPMRSMTVG 180 S+DF L R V + +D + + + H + I + + Sbjct: 19 SFDFSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHT-SLLAAGS 77 Query: 181 DDGSVVFYQGPPFKFSASDRTH----HKQGSFVRDVEFSPDSGEFVITVGSDRKISCFD- 235 D +V + + + V+ V +S D G ++ T D+ + ++ Sbjct: 78 FDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSND-GYYLATCSRDKSVWIWET 136 Query: 236 ---GKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVW-DVTTS-KCVQKW 290 G+ E + +++ + V+ I+ S A+ D T+R+W D +CV Sbjct: 137 DESGEEYECISVLQEHSQDVKHVIWHPSEA---LLASSSYDDTVRIWKDYDDDWECVAVL 193 Query: 291 TLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFY--------ELGHDEVLKTISG-HNKG 341 + + + G R+ S S D T+ + + + H + Sbjct: 194 NGHEGTVWSSDFD-KTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQ 252 Query: 342 ITALTV---NPLISGSYDGRIMEWSSSSMH 368 + + + S DG + + Sbjct: 253 VYNVAWGFNGLIASVGADGVLAVYEEVDGE 282 Score = 77.7 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 48/314 (15%), Positives = 87/314 (27%), Gaps = 38/314 (12%) Query: 81 LCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDN 140 L +G K+ + +D + + I ++W L Sbjct: 27 LATGSTDRKIKLVSVKYD----DFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSFD--- 79 Query: 141 FGVFISWDSGNS---------LGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGP 191 W S L + GH + + T D SV ++ Sbjct: 80 -STVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLA-TCSRDKSVWIWETD 137 Query: 192 -PFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSG--EFLKYIEDD 248 + + V+ V + P S + + D + + E + + Sbjct: 138 ESGEEYECISVLQEHSQDVKHVIWHP-SEALLASSSYDDTVRIWKDYDDDWECVAVLNGH 196 Query: 249 QEPVQGGIFALSWLDSQKFATVGADATIRVW-----DVTTSKCVQKWTLDKQQLGNQQVG 303 + V F + + + D+T+RVW D + + Q Sbjct: 197 EGTVWSSDFDKTEG-VFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYN 255 Query: 304 VVATGNGRIISLSLDGTLNF-------YELGHDEVLKTISGHNKGITALTVNP---LISG 353 V NG I S+ DG L +++ L + L +N L +G Sbjct: 256 VAWGFNGLIASVGADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVKWLELNGKTILATG 315 Query: 354 SYDGRIMEWSSSSM 367 DG + WS Sbjct: 316 GDDGIVNFWSLEKA 329 Score = 70.0 bits (169), Expect = 3e-12, Method: Composition-based stats. Identities = 36/251 (14%), Positives = 73/251 (29%), Gaps = 27/251 (10%) Query: 48 DGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVN 107 D ++ + GH + V YL + V +W + + + E Sbjct: 92 DRTFEMDLLAIIEGHENEVKGVA---WSNDGYYLATCSRDKSVWIW----ETDESGEEYE 144 Query: 108 VKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISW----DSGNSLGEVSGHSQRI 163 S Q + + + W L W D + ++GH + Sbjct: 145 CISVLQEHSQDVKHVIWHPSEALLASSSYD----DTVRIWKDYDDDWECVAVLNGHEGTV 200 Query: 164 NACHLKQSRP-MRSMTVGDDGSVVFY-----QGPPFKFSASDRTHHK-QGSFVRDVEFSP 216 + ++ R + DD +V + + + V +V + Sbjct: 201 WSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWG- 259 Query: 217 DSGEFVITVGSDRKISCF---DGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGAD 273 + +VG+D ++ + DG+ F K + L AT G D Sbjct: 260 -FNGLIASVGADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVKWLELNGKTILATGGDD 318 Query: 274 ATIRVWDVTTS 284 + W + + Sbjct: 319 GIVNFWSLEKA 329 Score = 58.8 bits (140), Expect = 6e-09, Method: Composition-based stats. Identities = 45/302 (14%), Positives = 108/302 (35%), Gaps = 37/302 (12%) Query: 326 LGHDEVLKTISGHNKGITALTVNP--LISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKA 383 + ++K++ + + I + + L +GS D +I S + D + + V + + Sbjct: 1 MASINLIKSLKLYKEKIWSFDFSQGILATGSTDRKIKL--VSVKYDDFTLIDVLDETAHK 58 Query: 384 QEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSV 443 + S++W + + F S + + T + DLL II+ Sbjct: 59 KAIRSVAWRPHTSL--LAAGSFDSTVSIWAKEESADR---TFEMDLL-------AIIEGH 106 Query: 444 RLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLR---AKPSYISISPSE 500 G A S Y+A + ++ +++ + ++ + L+ ++ PSE Sbjct: 107 ENEVKGVAWSNDGYYLATCSRD-KSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSE 165 Query: 501 TYIAAGDVMGKILLYDLQSREVK-TSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATG 559 +A+ + ++ + + + H + W ++ + +G Sbjct: 166 ALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTV----WSSD----FDKTEGVFRLCSG 217 Query: 560 SLDTNIFIY-----SVKRPMKIIKAL---NAHKDGVNNLLWETPSTLVSSGADACIKRWN 611 S D+ + ++ + + + HK V N+ W + S GAD + + Sbjct: 218 SDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNGLIASVGADGVLAVYE 277 Query: 612 VV 613 V Sbjct: 278 EV 279 Score = 50.7 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 37/153 (24%), Positives = 56/153 (36%), Gaps = 4/153 (2%) Query: 43 VRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESN 102 VR D D V GH +V ++ F +G LCSG + V VW + D E + Sbjct: 177 VRIWKDYDDDWECVAVLNGHEGTVWSS-DFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDD 235 Query: 103 SVEVNVKSEFQ-VLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQ 161 E ++ V + +++W F G V +G + + H Sbjct: 236 QQEWVCEAILPDVHKRQVYNVAWGFNGLIASVGADGVLAVYEEVDGEWKVFAKRALCHGV 295 Query: 162 R-INACH-LKQSRPMRSMTVGDDGSVVFYQGPP 192 IN L+ + T GDDG V F+ Sbjct: 296 YEINVVKWLELNGKTILATGGDDGIVNFWSLEK 328 >3JRO-A nrPDB Length = 753 Score = 78.0 bits (190), Expect = 1e-14, Method: Composition-based stats. Identities = 37/273 (13%), Positives = 81/273 (29%), Gaps = 36/273 (13%) Query: 78 SQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFE--GRRLCVVG 135 + L + + ++ + + GP+ + W G L Sbjct: 21 GKRLATCSSDKTIKIFEVEGE------THKLIDTLTGHEGPVWRVDWAHPKFGTILASCS 74 Query: 136 EGRDNFGVFISWDSGN----SLGEVSGHSQRINACHLKQSR-PMRSMTVGDDGSVVFYQG 190 G + W N + + HS +N+ + DG V + Sbjct: 75 YD----GKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEF 130 Query: 191 PPFKFSASDRTHHKQGSFVRDVEFSPDS------------GEFVITVGSDRKISCFDGKS 238 ++ V ++P + +T G+D + + S Sbjct: 131 KENGTTSPII-IDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNS 189 Query: 239 GEFLKYIEDDQEPVQGGIFALSWLDS----QKFATVGADATIRVWDVTTSKCVQKWTLDK 294 +E E + ++W + A+V D T +W + K TL K Sbjct: 190 DAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLK 249 Query: 295 QQLG-NQQVGVVATGNGRIISLS-LDGTLNFYE 325 ++ + + +G +++LS D + ++ Sbjct: 250 EEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 Score = 66.5 bits (160), Expect = 3e-11, Method: Composition-based stats. Identities = 46/295 (15%), Positives = 96/295 (32%), Gaps = 40/295 (13%) Query: 244 YIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVT--TSKCVQKWTLDKQQLGNQQ 301 E + + ++ AT +D TI++++V T K + T + + Sbjct: 4 IANAHNELIHDAVLDYY---GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 Query: 302 VGVVATGNGRIISLSLDGTLNFYELGHDE--VLKTISGHNKGITALTVNP------LISG 353 + S S DG + ++ + + + H+ + ++ P L+ Sbjct: 61 WA-HPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVA 119 Query: 354 SYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDD-----------TLKVNGITK 402 S DG++ ++ I + ++ A +S SW T + Sbjct: 120 SSDGKVSV--VEFKENGTTSPI--IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVT 175 Query: 403 HEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVG 462 + K+ N+D T VL + + +V L S ++VS + + Sbjct: 176 GGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRT-CIIW 234 Query: 463 LEEGNTIQVFK--LSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLY 515 ++ K L + + L S S S +A K+ L+ Sbjct: 235 TQDNEQGPWKKTLLKEEKFPDVLW--------RASWSLSGNVLALSGGDNKVTLW 281 Score = 65.7 bits (158), Expect = 6e-11, Method: Composition-based stats. Identities = 39/277 (14%), Positives = 103/277 (37%), Gaps = 27/277 (9%) Query: 309 NGRIISLSLDGTLNFYELG--HDEVLKTISGHNKGITALT-VNP-----LISGSYDGRIM 360 R+ + S D T+ +E+ +++ T++GH + + +P L S SYDG+++ Sbjct: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 Query: 361 EWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFT 420 W ++ +++ + +S+ W + + V +G T Sbjct: 81 IW----KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTT 136 Query: 421 AVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVS 480 + + D + + S + + G ++ V N ++++K + + Sbjct: 137 SPIIIDAHAIGVNSASW---APATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQT 193 Query: 481 FDLKTPLRAKPSYI---SISPS---ETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKI 534 + L++ L ++ + SP+ +Y+A+ +++ + + + K Sbjct: 194 YVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKF 253 Query: 535 NAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVK 571 + W+ A+ L +G D + ++ Sbjct: 254 PDVLWR-----ASWSLSGNVLALSGG-DNKVTLWKEN 284 Score = 49.2 bits (115), Expect = 6e-06, Method: Composition-based stats. Identities = 30/129 (23%), Positives = 51/129 (39%), Gaps = 28/129 (21%) Query: 500 ETYIAAGDVMGKILLY-DLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVAT 558 T +A+ GK+L++ + R + + A H++ +N++ W P E G L+ Sbjct: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGP--------LLLV 118 Query: 559 GSLDTNIFIYSVKR---PMKIIKALNAHKDGVNNLLWETPS--------------TLVSS 601 S D + + K II +A GVN+ W + V+ Sbjct: 119 ASSDGKVSVVEFKENGTTSPIIIDAHAI--GVNSASWAPATIEEDGEHNGTKESRKFVTG 176 Query: 602 GADACIKRW 610 GAD +K W Sbjct: 177 GADNLVKIW 185 >5MWJ-A nrPDB Length = 337 Score = 76.1 bits (185), Expect = 4e-14, Method: Composition-based stats. Identities = 58/323 (17%), Positives = 106/323 (32%), Gaps = 32/323 (9%) Query: 171 SRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHK-------QGSFVRDVEFSPDSGEFVI 223 S+P S V DG + PP H G V V S + V Sbjct: 9 SKPAYSFHVTADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTIS-NPTRHVY 67 Query: 224 TVGSDRKISCFDGK---SGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWD 280 T G + +D + + ++ D G +T+ +WD Sbjct: 68 TGG-KGCVKVWDISHPGNKSPVSQLDCLNRD-NYIRSCKLLPDGCTLIVGGEASTLSIWD 125 Query: 281 VTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNK 340 + K L + + + S DG + ++L + +++ GH Sbjct: 126 LAAPTPRIKAELTSSAPACYALAIS-PDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTD 184 Query: 341 GITALTVN----PLISGSYDGRIMEWSSSSMHQ----DHSNLIVSLDNSKAQEYSSISWD 392 G + + ++ L +G D + W Q D ++ I SL E+ ++ + Sbjct: 185 GASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGME 244 Query: 393 DT----LKVNGITKHEFG---SQPKVASANNDGFTAVLTNDDDLL-ILQSFTGDIIKSVR 444 + L VN K++ S G V T D+LL ++ G I + Sbjct: 245 SSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSK 304 Query: 445 LNSPGSA--VSLSQNYVAVGLEE 465 +S + +S+ Y+ G + Sbjct: 305 ESSSVLSCDISVDDKYIVTGSGD 327 Score = 72.3 bits (175), Expect = 7e-13, Method: Composition-based stats. Identities = 44/240 (18%), Positives = 82/240 (34%), Gaps = 16/240 (6%) Query: 166 CHLKQSRPMRSMTVGDDGSVVFYQG--PPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVI 223 C + S P R + G G V + P K S + +++R + PD G +I Sbjct: 55 CAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPD-GCTLI 113 Query: 224 TVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTT 283 G +S +D + E A+S DS+ + +D I VWD+ Sbjct: 114 VGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAIS-PDSKVCFSCCSDGNIAVWDLHN 172 Query: 284 SKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGIT 343 V+++ + ++ + LD T+ ++L L+ I Sbjct: 173 QTLVRQFQGHTDGASCIDIS---NDGTKLWTGGLDNTVRSWDLREGRQLQQHD-FTSQIF 228 Query: 344 ALTVNP----LISGSYDGRIMEWSSSS----MHQDHSNLIVSLDNSKAQEYSSISWDDTL 395 +L P L G + + H + ++SL + ++ + D L Sbjct: 229 SLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNL 288 Score = 50.3 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 54/288 (18%), Positives = 104/288 (36%), Gaps = 39/288 (13%) Query: 327 GHDEVLKTISGHNKGITALTVNPLISGSY---DGRIMEWSSSSMHQDHSNLIVSLDNSKA 383 H + T+ H + + A+T++ Y G + W S H + + + LD Sbjct: 40 RHARQINTL-NHGEVVCAVTISNPTRHVYTGGKGCVKVWDIS--HPGNKSPVSQLD---- 92 Query: 384 QEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSV 443 ++ D+ ++ + P + G + L+ D ++ S Sbjct: 93 ----CLNRDNYIRSCKLL-------PDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSA 141 Query: 444 RLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYI 503 A+S +GN I V+ L + + + S I IS T + Sbjct: 142 PA-CYALAISPDSKVCFSCCSDGN-IAVWDLHNQTLVRQFQGHTDGA-SCIDISNDGTKL 198 Query: 504 AAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDT 563 G + + +DL RE + + TS+I ++ + P + +A G + Sbjct: 199 WTGGLDNTVRSWDL--REGRQLQQHDFTSQIFSLGYCPTGEW----------LAVGMESS 246 Query: 564 NIFIYSVKRPMKIIKALNAHKDGVNNLLWETPST-LVSSGADACIKRW 610 N+ + V +P K L+ H+ V +L + VS+G D + W Sbjct: 247 NVEVLHVNKPDKY--QLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAW 292 Score = 48.4 bits (113), Expect = 9e-06, Method: Composition-based stats. Identities = 44/319 (13%), Positives = 90/319 (28%), Gaps = 67/319 (21%) Query: 11 PPQPSTQRNFTTHLSYDPTTNAIAYPC-------GKSAFVRCLDDGD-SKVPPVVQFTG- 61 P P R T L++ A+ G V+ D PV Q Sbjct: 36 PGIPRHARQINT-LNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCL 94 Query: 62 HGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISD 121 + + + + K P L G E+ + +W + + +K+E A Sbjct: 95 NRDNYIRSCKLLP--DGCTLIVGGEASTLSIW------DLAAPTPRIKAELTSSAPACYA 146 Query: 122 ISWDFEGRRLCVVGEGRDNFGVFISWDSGNS--LGEVSGHSQRINACHLKQSRPMRSMTV 179 ++ + + G WD N + + GH+ + + + T Sbjct: 147 LAISPDSKVCFSCCSD----GNIAVWDLHNQTLVRQFQGHTDGASCIDISNDG-TKLWTG 201 Query: 180 GDDGSVVFYQGPPFKFSAS-------------------------------------DRTH 202 G D +V + + Sbjct: 202 GLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQL 261 Query: 203 HKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWL 262 H S V ++F+ G++ ++ G D ++ + G + ++ + + Sbjct: 262 HLHESCVLSLKFA-YCGKWFVSTGKDNLLNAWRTPYGASIFQSKES----SSVLSCDISV 316 Query: 263 DSQKFATVGADATIRVWDV 281 D + T D V++V Sbjct: 317 DDKYIVTGSGDKKATVYEV 335 >3W15-A nrPDB Length = 368 Score = 75.7 bits (184), Expect = 5e-14, Method: Composition-based stats. Identities = 61/367 (16%), Positives = 120/367 (32%), Gaps = 74/367 (20%) Query: 59 FTGHGSSVVTTVKFSPIKGSQYLCS-GDESGKV---IVWGWTFDKESNSVEVNVKSEFQV 114 F+G+G V++SP ++ + G G V ++ D+ VEVN Sbjct: 11 FSGYG------VQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQDC 64 Query: 115 LAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPM 174 L D++W+ +V +G +F + + H + + +C+ Sbjct: 65 LF----DLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQ 120 Query: 175 RSMTVGDDGSVVFYQ------------------------GPPFKFSASDRTHHKQGSFVR 210 ++ DGS+ + S K + V Sbjct: 121 NFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVY 180 Query: 211 DVEFSPDSGEFVITVGSDRKISCFDGK--SGEFLKYIEDDQEPVQGGIFALSWLDSQKFA 268 +FSP V++ + S FD + SG+ ++ + A Sbjct: 181 QAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVH-SGLEALTCDFNKYRPYVVA 239 Query: 269 TVGADATIRVWDVT----------TSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLD 318 T G D IR+WD+ S C+ + + L ++V + ++S S D Sbjct: 240 TGGVDNAIRIWDIRMLNKNPGQLHNSSCINE-IPNAHGLAIRKVTWSPHHSNILMSASYD 298 Query: 319 GTLNFY-EL---------------GHDEVLKTISGHNKGI----TALTVNP--LISGSYD 356 T + +L + + H++ + +L P + S ++D Sbjct: 299 MTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWD 358 Query: 357 GRIMEWS 363 G + W+ Sbjct: 359 GNLFVWN 365 Score = 41.1 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 28/236 (11%), Positives = 60/236 (25%), Gaps = 56/236 (23%) Query: 15 STQRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSP 74 S RN + P + C +++ D F H T F+ Sbjct: 173 SKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNK 232 Query: 75 IKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVV 134 + + +G + +W ++ N + I++I Sbjct: 233 YR-PYVVATGGVDNAIRIWDIRMLNKNPGQLHN--------SSCINEIP----------- 272 Query: 135 GEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFY------ 188 + H I M+ D + + Sbjct: 273 ----------------------NAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSND 310 Query: 189 -QGPPFKFSASDRT------HHKQGSFVRDVEFSPDSGE-FVITVGSDRKISCFDG 236 +K +++D T + FV ++S +V + D + ++G Sbjct: 311 GAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWNG 366 Score = 30.7 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 33/206 (16%), Positives = 72/206 (34%), Gaps = 28/206 (13%) Query: 412 ASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQV 471 + +++ V D L + + + P + + V Q Sbjct: 70 WNESHENQVLVAQGDGTLRLFDTTFKEF--------PIAIFKEHEREVFSCNWNLVNRQN 121 Query: 472 FKLSDLEVSFDLKTPLRAKPSYISISPSETYIAA-GDVMGKILLYDLQSREVKTSRWAFH 530 F S + S + +PLR K S ++++P I D + I+L K + Sbjct: 122 FLSSSWDGSIKIWSPLR-KQSLMTLTPRPLEITKMVDPLNAIIL--------KKKSFTGI 172 Query: 531 TSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNL 590 + N + A +++LV + S ++ ++ ++ P + G+ L Sbjct: 173 SKNRNCV------YQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEAL 226 Query: 591 LWE----TPSTLVSSGADACIKRWNV 612 + P + + G D I+ W++ Sbjct: 227 TCDFNKYRPYVVATGGVDNAIRIWDI 252 >4AEZ-A nrPDB Length = 401 Score = 75.3 bits (183), Expect = 7e-14, Method: Composition-based stats. Identities = 68/387 (17%), Positives = 125/387 (32%), Gaps = 46/387 (11%) Query: 9 IIPPQPSTQRNFTTHLSYDPTTN---AIAYPCGKSAFVRCLD---DGDSKVPPVVQFTGH 62 IP +P+T F +S D + ++A CG R L D PV T H Sbjct: 3 FIPSRPNTANAFVNSISSDVPFDYSESVAEACGFDLNTRVLAFKLDAPEAKKPVDLRTQH 62 Query: 63 ---GSSVVTTVKFSPIKGSQYLCSG-----DESGKVIVWGWTFDKESNSVEVNVKSEFQV 114 VVT K + + D ++ W + + ++E NV + Sbjct: 63 NRPQRPVVTPAKRRFNTTPERVLDAPGIIDDYYLNLLDWS-NLNVVAVALERNV-YVWNA 120 Query: 115 LAGPISDISWDFEGRRLCVVGEGRDNF--------GVFISWD--SGNSLGEVSGHSQRIN 164 +G +S ++ E + V D G+ +D S L ++GH R+ Sbjct: 121 DSGSVSALAETDESTYVASVKWSHDGSFLSVGLGNGLVDIYDVESQTKLRTMAGHQARVG 180 Query: 165 ACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVIT 224 R + S + + T S V + + D G + + Sbjct: 181 CLSW-----NRHVLSSGSRSGAIHHHDVRIANHQIGTLQGHSSEVCGLAWRSD-GLQLAS 234 Query: 225 VGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTS 284 G+D + +D +S + V+ + + D I W+ T Sbjct: 235 GGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAATG 294 Query: 285 KCVQKWTLDKQQLGNQQVGVVATG-NGRIISLSL--DGTLNFYELGHDEVLKT--ISGHN 339 V G+Q ++ + + I+S D L+ + + K I H+ Sbjct: 295 ARVNTV-----DAGSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIPAHD 349 Query: 340 KGITALTVNP----LISGSYDGRIMEW 362 + ++P L + + D + W Sbjct: 350 TRVLYSALSPDGRILSTAASDENLKFW 376 Score = 64.9 bits (156), Expect = 9e-11, Method: Composition-based stats. Identities = 42/310 (13%), Positives = 105/310 (33%), Gaps = 43/310 (13%) Query: 222 VITVGSDRKISCFDGKSGEFLKYIEDDQEP-VQGGIFALSWLDSQKFATVGADATIRVWD 280 V+ V +R + ++ SG E D+ V ++ D + + + ++D Sbjct: 106 VVAVALERNVYVWNADSGSVSALAETDESTYVASVKWS---HDGSFLSVGLGNGLVDIYD 162 Query: 281 VTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELG-HDEVLKTISGHN 339 V + ++ +VG ++ + S S G ++ +++ + + T+ GH+ Sbjct: 163 VESQTKLRTMAGH-----QARVGCLSWNRHVLSSGSRSGAIHHHDVRIANHQIGTLQGHS 217 Query: 340 KGITALTVN----PLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTL 395 + L L SG D + W + S + + +++W Sbjct: 218 SEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFT------KTNHNAAVKAVAWCPW- 270 Query: 396 KVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLS 455 Q + + T D + + TG + +V S +++ S Sbjct: 271 ------------QSNLLATGGG------TMDKQIHFWNAATGARVNTVDAGSQVTSLIWS 312 Query: 456 QNYVAVGLEEG---NTIQVFKLSDLEVSFDLKTPLR-AKPSYISISPSETYIAAGDVMGK 511 + + G N + ++ S ++ + P + Y ++SP ++ Sbjct: 313 PHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIPAHDTRVLYSALSPDGRILSTAASDEN 372 Query: 512 ILLYDLQSRE 521 + + + + Sbjct: 373 LKFWRVYDGD 382 Score = 51.8 bits (122), Expect = 8e-07, Method: Composition-based stats. Identities = 29/144 (20%), Positives = 59/144 (40%), Gaps = 14/144 (9%) Query: 469 IQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWA 528 + V+ VS +T + + S ++++ G G + +YD++S+ K A Sbjct: 115 VYVWNADSGSVSALAETDESTYVASVKWSHDGSFLSVGLGNGLVDIYDVESQ-TKLRTMA 173 Query: 529 FHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVN 588 H +++ +SW ++++GS I + V+ I L H V Sbjct: 174 GHQARVGCLSW------------NRHVLSSGSRSGAIHHHDVRIANHQIGTLQGHSSEVC 221 Query: 589 NLLWETPSTLVSSGA-DACIKRWN 611 L W + ++SG D ++ W+ Sbjct: 222 GLAWRSDGLQLASGGNDNVVQIWD 245 >5WLC-LU nrPDB Length = 489 Score = 74.6 bits (181), Expect = 1e-13, Method: Composition-based stats. Identities = 46/340 (13%), Positives = 105/340 (30%), Gaps = 48/340 (14%) Query: 292 LDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITAL------ 345 + G + ++ + S DG + ++ + E + H +T L Sbjct: 63 GYGHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPR 122 Query: 346 ---------TVNPLISGSYDGRIMEWSSS-SMHQDHSNLIVSLDNSKAQEYSSISWDDTL 395 + N ++S S D + WS + + + ++ ++ + + Sbjct: 123 FHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAF 182 Query: 396 KVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRL---NSPGSAV 452 + GI H S T + + + + N Sbjct: 183 Q--GIDSHRENST-------------FATGGAKIHLWDVNRLKPVSDLSWGADNITSLKF 227 Query: 453 SLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETY-IAAGDVMGK 511 + ++ + N+I ++ L + + +R + I +P E + + Sbjct: 228 NQNETDILASTGSDNSIVLYDLRTNSPTQKIVQTMRT--NAICWNPMEAFNFVTANEDHN 285 Query: 512 ILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVK 571 YD+++ + + H S + + + P D + TGS D +I IY Sbjct: 286 AYYYDMRNLSRSLNVFKDHVSAVMDVDFSPT----------GDEIVTGSYDKSIRIYKTN 335 Query: 572 RPMKIIKALNAHKDGVNNLLWETPSTLVSSGA-DACIKRW 610 V + + S + SG+ D ++ W Sbjct: 336 HGHSREIYHTKRMQHVFQVKYSMDSKYIISGSDDGNVRLW 375 Score = 73.0 bits (177), Expect = 4e-13, Method: Composition-based stats. Identities = 50/330 (15%), Positives = 100/330 (30%), Gaps = 39/330 (11%) Query: 61 GHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVK--SEFQVLAGP 118 GH V K L +G G + W + +E S + + + V Sbjct: 65 GHRDGVYAIAKNYGSLNK--LATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPR 122 Query: 119 ISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINA----CHLKQSRPM 174 D D + + + ++ S S + N Sbjct: 123 FHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAF 182 Query: 175 RSMTVGDDGS--------VVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVG 226 + + + S + + K + ++F+ + + + + G Sbjct: 183 QGIDSHRENSTFATGGAKIHLWDVNRLK---PVSDLSWGADNITSLKFNQNETDILASTG 239 Query: 227 SDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQ--KFATVGADATIRVWDVTT- 283 SD I +D ++ + I A+ W + F T D +D+ Sbjct: 240 SDNSIVLYDLRTNSPTQKIVQTMR-----TNAICWNPMEAFNFVTANEDHNAYYYDMRNL 294 Query: 284 SKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGI- 342 S+ + + V TG+ I++ S D ++ Y+ H + H K + Sbjct: 295 SRSLNVFK--DHVSAVMDVDFSPTGD-EIVTGSYDKSIRIYKTNHGHSREIY--HTKRMQ 349 Query: 343 ------TALTVNPLISGSYDGRIMEWSSSS 366 ++ +ISGS DG + W S + Sbjct: 350 HVFQVKYSMDSKYIISGSDDGNVRLWRSKA 379 Score = 71.9 bits (174), Expect = 8e-13, Method: Composition-based stats. Identities = 51/340 (15%), Positives = 108/340 (31%), Gaps = 55/340 (16%) Query: 203 HKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGG-----IF 257 + V + + S + T +D I ++ + E + V G F Sbjct: 64 YGHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPRF 123 Query: 258 ALSWLDSQK---FATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIIS 314 D + + D T+++W + K + D + N++ G++ T +G Sbjct: 124 HDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEE-GLIRTFDGESAF 182 Query: 315 LSLD------------GTLNFYELGHDEVLKTISGHNKGITALTVNP-----LISGSYDG 357 +D ++ +++ + + +S IT+L N L S D Sbjct: 183 QGIDSHRENSTFATGGAKIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSDN 242 Query: 358 RIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANND 417 I+ + + + N +I W+ N +T +E + N Sbjct: 243 SIVLYDLRTNSPTQKIVQTMRTN-------AICWNPMEAFNFVTANEDHNAYYYDMRNLS 295 Query: 418 GFTAVLTNDDDLLILQSF--TGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLS 475 V + ++ F TGD I + + G++ +++ Sbjct: 296 RSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIY---------KTNHGHSREIYHTK 346 Query: 476 DLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLY 515 ++ F +K S YI +G G + L+ Sbjct: 347 RMQHVFQVK-----------YSMDSKYIISGSDDGNVRLW 375 Score = 65.3 bits (157), Expect = 7e-11, Method: Composition-based stats. Identities = 46/272 (16%), Positives = 96/272 (35%), Gaps = 35/272 (12%) Query: 157 SGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHK--QGSFVRDVEF 214 GH + A + T DG + ++ + S + H+ G V F Sbjct: 64 YGHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPRF 123 Query: 215 S---PD--SGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQ---GGIFAL------- 259 PD S F+++ D+ + + ++ D + V G I Sbjct: 124 HDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAFQ 183 Query: 260 ---SWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLS 316 S ++ FAT G A I +WDV K V L + + S Sbjct: 184 GIDSHRENSTFATGG--AKIHLWDVNRLKPVSD--LSWGADNITSLKFNQNETDILASTG 239 Query: 317 LDGTLNFYELG----HDEVLKTISGHNKGITALTVNPLISGSYDGRIMEWS------SSS 366 D ++ Y+L ++++T+ + + ++ + D + S + Sbjct: 240 SDNSIVLYDLRTNSPTQKIVQTMRTNAICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLN 299 Query: 367 MHQDHSNLIVSLDNSKAQE-YSSISWDDTLKV 397 + +DH + ++ +D S + + S+D ++++ Sbjct: 300 VFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRI 331 Score = 32.2 bits (71), Expect = 0.64, Method: Composition-based stats. Identities = 16/96 (16%), Positives = 34/96 (35%), Gaps = 17/96 (17%) Query: 24 LSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFS------PIKG 77 + + PT + I ++ + + + GH + T + Sbjct: 311 VDFSPTGDEIV----TGSYDKSIRIYKTN-------HGHSREIYHTKRMQHVFQVKYSMD 359 Query: 78 SQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQ 113 S+Y+ SG + G V +W + SN K++ + Sbjct: 360 SKYIISGSDDGNVRLWRSKAWERSNVKTTREKNKLE 395 >2PM9-A nrPDB Length = 416 Score = 74.2 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 47/299 (15%), Positives = 94/299 (31%), Gaps = 30/299 (10%) Query: 85 DESGKVIVWGW-TFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVV--GEGRDNF 141 + +W D E + V S+F +D+ W + + + + Sbjct: 42 STDSSLELWSLLAADSEKPIASLQVDSKF-------NDLDWSHNNKIIAGALDNGSLELY 94 Query: 142 GVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRT 201 + ++ NS+ S HS + + + G++G + + S S+ T Sbjct: 95 STNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYT 154 Query: 202 HHKQG------SFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGG 255 G V + ++ + GS S +D K+ + + ++ P G Sbjct: 155 PLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHL-SYTSPNSGI 213 Query: 256 IFALSWL-----DSQKFATVGA---DATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVAT 307 LS + +S + AT D +I +WD+ + + Q G + Sbjct: 214 KQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQ 273 Query: 308 GNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP-----LISGSYDGRIME 361 ++S D T+ + E L P S+D +I Sbjct: 274 DEHLLLSSGRDNTVLLWNPESAEQLSQFPARGNWCFKTKFAPEAPDLFACASFDNKIEV 332 Score = 64.9 bits (156), Expect = 8e-11, Method: Composition-based stats. Identities = 47/261 (18%), Positives = 94/261 (36%), Gaps = 30/261 (11%) Query: 167 HLKQSRPMRSMTVG-DDGSVVFYQGPPFKFSA-SDRTHHKQGSFVRDVEFSPDSGEFVIT 224 L S + + D+GS+ Y + S S V+ V+F+ + + Sbjct: 72 DLDWSHNNKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLAS 131 Query: 225 VGSDRKISCFDGKSGEF-----LKYIEDDQEPVQGGIFALSWLDS--QKFATVGADATIR 277 G++ +I +D + +L+W S FA+ G+ Sbjct: 132 GGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFAS 191 Query: 278 VWDVTTSKCVQKWTLDKQQLGNQQ----VGVVATGNGRIISLS---LDGTLNFYELGHDE 330 +WD+ K V + G +Q V + R+ + + D ++ ++L + Sbjct: 192 IWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNAN 251 Query: 331 V-LKTI-SGHNKGITALTV-----NPLISGSYDGRIMEWSS-----SSMHQDHSNLIVSL 378 L+T+ GH KGI +L + L+S D ++ W+ S N Sbjct: 252 TPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQFPARGNWCFKT 311 Query: 379 DNSKAQ--EYSSISWDDTLKV 397 + ++ S+D+ ++V Sbjct: 312 KFAPEAPDLFACASFDNKIEV 332 Score = 37.2 bits (84), Expect = 0.019, Method: Composition-based stats. Identities = 44/282 (15%), Positives = 99/282 (35%), Gaps = 38/282 (13%) Query: 326 LGHDEVLKTISGHNKGITALTVNPLISGSYDGRIMEWSSSSMHQD----HSNLIVS--LD 379 L V T+ + ++L + L++ + I S D H+N I++ LD Sbjct: 28 LVSGTVSGTVDANFSTDSSLELWSLLAADSEKPIASLQVDSKFNDLDWSHNNKIIAGALD 87 Query: 380 NSKAQEYSSISWDDTL-KVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFT-- 436 N + YS+ ++ + + + H + +A D A N+ ++ I Sbjct: 88 NGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCT 147 Query: 437 ------GDIIKSVRLNSPGSAVSLSQN------YVAVGLEEGNTIQVFKLSDLEVSFDLK 484 + ++S +SL+ N + + G +I K + Sbjct: 148 ESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYT 207 Query: 485 TP---LRAKPSYISISPSETYIAAG----DVMGKILLYDLQSREVKTSRW-AFHTSKINA 536 +P ++ + S + P + A D IL++DL++ H I + Sbjct: 208 SPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILS 267 Query: 537 ISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIK 578 + W +E L+ + D + +++ + ++ + Sbjct: 268 LDW---------CHQDEHLLLSSGRDNTVLLWNPESAEQLSQ 300 Score = 33.4 bits (74), Expect = 0.34, Method: Composition-based stats. Identities = 24/139 (17%), Positives = 52/139 (37%), Gaps = 22/139 (15%) Query: 487 LRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTS---RWAFHTSKINAISWKPAE 543 + +K + + S + IA G + LY + R++ H+S + + + Sbjct: 66 VDSKFNDLDWSHNNKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAK- 124 Query: 544 KGANEEEIEEDLVATGSLDTNIFIYSVKR----PMKIIKALNAHK----DGVNNLLWETP 595 +++++A+G + IFI+ + + P D V +L W Sbjct: 125 --------QDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQS 176 Query: 596 STLV--SSGADACIKRWNV 612 V S+G+ W++ Sbjct: 177 LAHVFASAGSSNFASIWDL 195 >4G56-B nrPDB Length = 357 Score = 74.2 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 49/290 (16%), Positives = 96/290 (33%), Gaps = 13/290 (4%) Query: 92 VWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGN 151 +W + D E E + Q AG ++D++W E L G + +S Sbjct: 72 IWVFK-DPEGAPNESLCTAGVQTEAG-VTDVAWVSEKGILVASDSGAVELWEILEKESLL 129 Query: 152 SLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRD 211 I S ++++ G D SV + A ++++ S V Sbjct: 130 VNKFAKYEHDDIVKTLSVFSDGTQAVSGGKDFSVKVWDLSQ---KAVLKSYNAHSSEVNC 186 Query: 212 VEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVG 271 V P ++ G D +I +D + + I D +++W + Sbjct: 187 VAACPGKDTIFLSCGEDGRILLWDTRKPKPATRI--DFCASDTIPTSVTWHPEKDDTFAC 244 Query: 272 ADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEV 331 D T V V T + + + S+S D T+ + EV Sbjct: 245 GDETGNVSLVNIKNPDSAQTSAVHSQNITGLAYSYHSSPFLASISEDCTVAVLDADFSEV 304 Query: 332 LKTISGHNKGITALTVNPL-----ISGSYDGRIMEWSSSSMHQDHSNLIV 376 + +S H +T + +PL + +D +++ S + + + Sbjct: 305 FRDLS-HRDFVTGVAWSPLDHSKFTTVGWDHKVLHHHLPSEGRTENLIAT 353 Score = 67.3 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 37/226 (16%), Positives = 78/226 (34%), Gaps = 35/226 (15%) Query: 253 QGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGV-VATGNGR 311 + G+ ++W+ + + +W++ + + K + + + V + + Sbjct: 94 EAGVTDVAWVSEKGILVASDSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSDGTQ 153 Query: 312 IISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP-----LISGSYDGRIMEWSSSS 366 +S D ++ ++L VLK+ + H+ + + P +S DGRI+ W + Sbjct: 154 AVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTRK 213 Query: 367 MHQ----------------------------DHSNLIVSLDNSKAQEYSSISWDDTLKVN 398 VSL N K + + S + + Sbjct: 214 PKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLVNIKNPDSAQTSAVHSQNIT 273 Query: 399 GITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVR 444 G+ + + S P +AS + D AVL D + D + V Sbjct: 274 GL-AYSYHSSPFLASISEDCTVAVLDADFSEVFRDLSHRDFVTGVA 318 Score = 39.5 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 27/200 (13%), Positives = 64/200 (32%), Gaps = 33/200 (16%) Query: 431 ILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAK 490 I + + L + G VA E+G ++ + +L L + Sbjct: 72 IWVFKDPEGAPNESLCTAGVQTEAGVTDVAWVSEKG-----ILVASDSGAVELWEILEKE 126 Query: 491 ---------------PSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKIN 535 +S+ T +G + ++DL S++ + H+S++N Sbjct: 127 SLLVNKFAKYEHDDIVKTLSVFSDGTQAVSGGKDFSVKVWDL-SQKAVLKSYNAHSSEVN 185 Query: 536 AISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGV-NNLLW-- 592 ++ P ++ + + D I ++ ++P + D + ++ W Sbjct: 186 CVAACPG---------KDTIFLSCGEDGRILLWDTRKPKPATRIDFCASDTIPTSVTWHP 236 Query: 593 ETPSTLVSSGADACIKRWNV 612 E T + N+ Sbjct: 237 EKDDTFACGDETGNVSLVNI 256 >4U1E-I nrPDB Length = 347 Score = 73.8 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 55/336 (16%), Positives = 118/336 (35%), Gaps = 43/336 (12%) Query: 202 HHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSW 261 + V+++ + G+ + + D S + +GE L ++ + Sbjct: 6 LTGHERPLTQVKYNKE-GDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCF- 63 Query: 262 LDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISL----SL 317 ++ T AD +I++WDV+ +CV W K + ++V GN + L Sbjct: 64 --TKYCVTGSADYSIKLWDVSNGQCVATW---KSPVPVKRVEFSPCGNYFLAILDNVMKN 118 Query: 318 DGTLNFYELGHDEVLKTISGHNKGITALTVNPLIS--GSYDGRIMEWSSSSMH--QDHSN 373 G++N YE+ D ++ ++ ++ +I+ G + WS+ + H + Sbjct: 119 PGSINIYEIERDSATHELT----KVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKD 174 Query: 374 LIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQ 433 +S + S D K + + + D + ++ Sbjct: 175 GKISKYDVSNNYEYVDSIDLHEKSISDMQFSPDLT----------YFITSSRDTNSFLVD 224 Query: 434 SFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQ-VFKLSDLEVSFDLK---TPLRA 489 T ++K + P + ++ + L G + V S E F+ + Sbjct: 225 VSTLQVLKKYETDCPLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEE 284 Query: 490 KP----------SYISISPSETYIAAGDVMGKILLY 515 + + ++ISP T A+G G I L+ Sbjct: 285 EIGRVQGHFGPLNTVAISPQGTSYASGGEDGFIRLH 320 Score = 61.1 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 40/241 (16%), Positives = 79/241 (32%), Gaps = 27/241 (11%) Query: 112 FQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQS 171 P++ + ++ EG L + + +G LG + GH+ I + + Sbjct: 6 LTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSL--NGERLGTLDGHTGTIWSIDVDCF 63 Query: 172 RPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVIT------- 224 +T D S+ + + A+ ++ V+ VEFSP G + + Sbjct: 64 TKY-CVTGSADYSIKLWDVSNGQCVATWKS----PVPVKRVEFSP-CGNYFLAILDNVMK 117 Query: 225 --VGSDRKISCFDGKSGEFLKYIED------DQEPVQGGIFALSWLDSQKFATVGADATI 276 + D + E K E+ E + A + D I Sbjct: 118 NPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKI 177 Query: 277 RVWDVTTSKC-VQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTI 335 +DV+ + V L ++ + + Q + I+ S D ++ +VLK Sbjct: 178 SKYDVSNNYEYVDSIDLHEKSISDMQ---FSPDLTYFITSSRDTNSFLVDVSTLQVLKKY 234 Query: 336 S 336 Sbjct: 235 E 235 Score = 55.3 bits (131), Expect = 7e-08, Method: Composition-based stats. Identities = 44/258 (17%), Positives = 74/258 (28%), Gaps = 56/258 (21%) Query: 334 TISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSI 389 ++GH + +T + N L S S D W S + + + + SI Sbjct: 5 KLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGER------LGTLDGHTGTIWSI 58 Query: 390 SWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPG 449 D K K+ +N A + Sbjct: 59 DVDCFTKY--CVTGSADYSIKLWDVSNGQCVAT------------------WKSPVPVKR 98 Query: 450 SAVSLSQNYVAVGL----EEGNTIQVFKLSDLEVSFDL----KTPLRAKPSY-------- 493 S NY L + +I ++++ + +L + P+ ++ Sbjct: 99 VEFSPCGNYFLAILDNVMKNPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATV 158 Query: 494 ISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEE 553 S YI AG GKI YD+ + H I+ + + P Sbjct: 159 AGWSTKGKYIIAGHKDGKISKYDVSNNYEYVDSIDLHEKSISDMQFSPDLTY-------- 210 Query: 554 DLVATGSLDTNIFIYSVK 571 T S DTN F+ V Sbjct: 211 --FITSSRDTNSFLVDVS 226 >5K0Y-T nrPDB Length = 329 Score = 73.0 bits (177), Expect = 3e-13, Method: Composition-based stats. Identities = 50/324 (15%), Positives = 95/324 (29%), Gaps = 78/324 (24%) Query: 112 FQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDS--GNSLGEVSGHSQRINACHLK 169 Q I+ I ++ EG L V + + W S G LG GH+ + Sbjct: 6 LQGHERSITQIKYNREGDLLFTVAKD----PIVNVWYSVNGERLGTYMGHTGAVWCVD-A 60 Query: 170 QSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRD-----VEFSPDS------ 218 +T D S + K A +T+ + D + FS D Sbjct: 61 DWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQC 120 Query: 219 -------------------------------------GEFVITVGSDRKISCFDGKSGEF 241 GE +I +++ + KSGE Sbjct: 121 FVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEV 180 Query: 242 LKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQ 301 L +++ + + + F T D T +++D TT + + + + + + Sbjct: 181 LVNVKEHSRQINDIQLS---REMTMFVTASKDNTAKLFDSTTLEHQKTFRTEPPR---EL 234 Query: 302 VGVVATGNGRIISLSLDGT-------------LNFYELGHDEVLKTISGHNKGITALTVN 348 + ++ + F+ L +E + GH I ++ + Sbjct: 235 AALSPNYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFH 294 Query: 349 P----LISGSYDGRIMEWSSSSMH 368 P SG DG + + Sbjct: 295 PDGKSYSSGGEDGYVRIHYFDPQY 318 Score = 68.4 bits (165), Expect = 8e-12, Method: Composition-based stats. Identities = 59/341 (17%), Positives = 118/341 (34%), Gaps = 61/341 (17%) Query: 202 HHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSW 261 + ++++ + G+ + TV D ++ + +GE L V W Sbjct: 6 LQGHERSITQIKYNRE-GDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAV--WCVDADW 62 Query: 262 LDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDG-- 319 D++ T AD + R+WD T K + L K + G GN II S D Sbjct: 63 -DTKHVLTGSADNSCRLWDCETGKQLA---LLKTNSAVRTCGFDFGGN--IIMFSTDKQM 116 Query: 320 ----TLNFYELGHDEVL------KTISGHNKGITALTVNPL----ISGSYDGRIMEWSSS 365 ++F++L + I ++ IT+ PL I+G G + ++S+ Sbjct: 117 GYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAK 176 Query: 366 SMH-----QDHSNLIVSLDNS-KAQEYSSISWDDTLKVNGITKHEFGSQ-----PKVASA 414 S ++HS I + S + + + S D+T K+ T E P+ +A Sbjct: 177 SGEVLVNVKEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFRTEPPRELAA 236 Query: 415 NNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKL 474 + + V+ + + T I + ++ + + V G Sbjct: 237 LSPNYEHVVVGGGQEAMDVTTTSTRIGK--FEARFFHLAFEEEFGRVKGHFG-------- 286 Query: 475 SDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLY 515 + ++ P ++G G + ++ Sbjct: 287 ---------------PINSVAFHPDGKSYSSGGEDGYVRIH 312 >3JRP-A nrPDB Length = 379 Score = 72.6 bits (176), Expect = 5e-13, Method: Composition-based stats. Identities = 36/271 (13%), Positives = 81/271 (29%), Gaps = 32/271 (11%) Query: 78 SQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEG 137 + L + + ++ + + GP+ + W + Sbjct: 23 GKRLATCSSDKTIKIFEVEGE------THKLIDTLTGHEGPVWRVDWAHPKFGTILASCS 76 Query: 138 RDNFGVFISWDSGN----SLGEVSGHSQRINACHLKQSR-PMRSMTVGDDGSVVFYQGPP 192 D G + W N + + HS +N+ + DG V + Sbjct: 77 YD--GKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKE 134 Query: 193 FKFSASDRTHHKQGSFVRDVEFSPDS------------GEFVITVGSDRKISCFDGKSGE 240 ++ V ++P + +T G+D + + S Sbjct: 135 NGTTSPII-IDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDA 193 Query: 241 FLKYIEDDQEPVQGGIFALSWLDS----QKFATVGADATIRVWDVTTSKCVQKWTLDKQQ 296 +E E + ++W + A+V D T +W + K TL K++ Sbjct: 194 QTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEE 253 Query: 297 LG-NQQVGVVATGNGRIISLS-LDGTLNFYE 325 + + +G +++LS D + ++ Sbjct: 254 KFPDVLWRASWSLSGNVLALSGGDNKVTLWK 284 Score = 62.6 bits (150), Expect = 5e-10, Method: Composition-based stats. Identities = 46/296 (15%), Positives = 97/296 (32%), Gaps = 32/296 (10%) Query: 239 GEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVT--TSKCVQKWTLDKQQ 296 G + E + + ++ AT +D TI++++V T K + T + Sbjct: 1 GSMVVIANAHNELIHDAVLDYY---GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGP 57 Query: 297 LGNQQVGVVATGNGRIISLSLDGTLNFYELGHDE--VLKTISGHNKGITALTVNP----- 349 + + S S DG + ++ + + + H+ + ++ P Sbjct: 58 VWRVDWA-HPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGP 116 Query: 350 -LISGSYDGRIME-------WSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGIT 401 L+ S DG++ +S + H+ + S + A + T + Sbjct: 117 LLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFV 176 Query: 402 KHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAV 461 + K+ N+D T VL + + +V L S ++VS + + Sbjct: 177 TGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRT-CII 235 Query: 462 GLEEGNTIQVFK--LSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLY 515 ++ K L + + L S S S +A K+ L+ Sbjct: 236 WTQDNEQGPWKKTLLKEEKFPDVLW--------RASWSLSGNVLALSGGDNKVTLW 283 Score = 60.7 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 39/277 (14%), Positives = 103/277 (37%), Gaps = 27/277 (9%) Query: 309 NGRIISLSLDGTLNFYELG--HDEVLKTISGHNKGITALT-VNP-----LISGSYDGRIM 360 R+ + S D T+ +E+ +++ T++GH + + +P L S SYDG+++ Sbjct: 23 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 82 Query: 361 EWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFT 420 W ++ +++ + +S+ W + + V +G T Sbjct: 83 IW----KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTT 138 Query: 421 AVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVS 480 + + D + + S + + G ++ V N ++++K + + Sbjct: 139 SPIIIDAHAIGVNSASW---APATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQT 195 Query: 481 FDLKTPLRAKPSYI---SISPS---ETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKI 534 + L++ L ++ + SP+ +Y+A+ +++ + + + K Sbjct: 196 YVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKF 255 Query: 535 NAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVK 571 + W+ A+ L +G D + ++ Sbjct: 256 PDVLWR-----ASWSLSGNVLALSGG-DNKVTLWKEN 286 Score = 45.7 bits (106), Expect = 5e-05, Method: Composition-based stats. Identities = 39/215 (18%), Positives = 75/215 (34%), Gaps = 50/215 (23%) Query: 418 GFTAVLTNDDDLLILQS---FTGDIIKSVRLNSPGSAVSLS-QNYVAVGLEEGNTIQVFK 473 G V+ N + LI + + G + + + + + + + G+ V++ Sbjct: 1 GSMVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWR 60 Query: 474 LSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLY-DLQSREVKTSRWAFHTS 532 + F T +A+ GK+L++ + R + + A H++ Sbjct: 61 VDWAHPKF------------------GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSA 102 Query: 533 KINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKR---PMKIIKALNAHKDGVNN 589 +N++ W P E G L+ S D + + K II +A GVN+ Sbjct: 103 SVNSVQWAPHEYGP--------LLLVASSDGKVSVVEFKENGTTSPIIIDAHAI--GVNS 152 Query: 590 LLWETPS--------------TLVSSGADACIKRW 610 W + V+ GAD +K W Sbjct: 153 ASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 187 >5A9Q-2 nrPDB Length = 326 Score = 71.1 bits (172), Expect = 1e-12, Method: Composition-based stats. Identities = 53/319 (16%), Positives = 107/319 (33%), Gaps = 38/319 (11%) Query: 67 VTTVKFSPIKG--SQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQV--LAGPISDI 122 V V+F+P + S L + + V++ TF +E VE + + I Sbjct: 19 VHVVEFNPFENGDSGNLIAYGGNNYVVIGTCTFQEEEADVEGIQYKTLRTFHHGVRVDGI 78 Query: 123 SWDFEGRR---------LCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRP 173 +W E R + + D + GH+ IN Sbjct: 79 AWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNE-YKVLEGHTDFINGLVFDPKEG 137 Query: 174 MRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISC 233 +V DD + + + + H S V + P+ ++ + I Sbjct: 138 QEIASVSDDHTCRIWNLEGVQTA-----HFVLHSPGMSVCWHPEETFKLMVAEKNGTIRF 192 Query: 234 FDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLD 293 +D + + + +E +Q P+ + L + A G D I WD+T S + + Sbjct: 193 YDLLAQQAILSLESEQVPLMSAHWCLKN-TFKVGAVAGNDWLI--WDITRSS----YPQN 245 Query: 294 KQQLG-NQQVGVVAT--GNGRIISLSLDGTLN----FYELGHDEVLKTISGHNKGITALT 346 K+ + ++ + + G + + LGH + + + G + L+ Sbjct: 246 KRPVHMDRACLFRWSTISENLFATTGYPGKMASQFQIHHLGHPQPI--LMGSVAVGSGLS 303 Query: 347 VN---PLISGSYDGRIMEW 362 + PL D +++ W Sbjct: 304 WHRTLPLCVIGGDHKLLFW 322 Score = 47.2 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 20/101 (19%), Positives = 34/101 (33%), Gaps = 16/101 (15%) Query: 287 VQKWTLDKQQLGNQQVGVVATGNGRIIS---------LSLDGTLNFY--ELGHDEVLKTI 335 +Q TL G + G+ + R+ S + D + + +L K + Sbjct: 61 IQYKTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVL 120 Query: 336 SGHNKGITALTVNP-----LISGSYDGRIMEWSSSSMHQDH 371 GH I L +P + S S D W+ + H Sbjct: 121 EGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAH 161 Score = 31.8 bits (70), Expect = 0.86, Method: Composition-based stats. Identities = 35/271 (12%), Positives = 87/271 (32%), Gaps = 40/271 (14%) Query: 339 NKGITALTVNPLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKA--------QEYSSIS 390 + + NP +G I + ++ +++ + Q + + Sbjct: 16 EDYVHVVEFNPFENGDSGNLI-------AYGGNNYVVIGTCTFQEEEADVEGIQYKTLRT 68 Query: 391 WDDTLKVNGIT---KHEFGSQP---KVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVR 444 + ++V+GI + S P K ++ D + T+D + +++ Sbjct: 69 FHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSD----LQDKNEYKVLEGHT 124 Query: 445 LNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETY-I 503 G + + + +T +++ L ++ + + L + + P ET+ + Sbjct: 125 DFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFV---LHSPGMSVCWHPEETFKL 181 Query: 504 AAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDT 563 + G I YDL +++ S + ++A W ++ Sbjct: 182 MVAEKNGTIRFYDLLAQQAILSLESEQVPLMSA-HW----------CLKNTFKVGAVAGN 230 Query: 564 NIFIYSVKRPMKIIKALNAHKDGVNNLLWET 594 + I+ + R H D W T Sbjct: 231 DWLIWDITRSSYPQNKRPVHMDRACLFRWST 261 >4BZK-B nrPDB Length = 297 Score = 71.1 bits (172), Expect = 1e-12, Method: Composition-based stats. Identities = 36/271 (13%), Positives = 81/271 (29%), Gaps = 32/271 (11%) Query: 78 SQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEG 137 + L + + ++ + + GP+ + W + Sbjct: 21 GKRLATCSSDKTIKIFEVEGE------THKLIDTLTGHEGPVWRVDWAHPKFGTILASCS 74 Query: 138 RDNFGVFISWDSGN----SLGEVSGHSQRINACHLKQSR-PMRSMTVGDDGSVVFYQGPP 192 D G + W N + + HS +N+ + DG V + Sbjct: 75 YD--GKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKE 132 Query: 193 FKFSASDRTHHKQGSFVRDVEFSPDS------------GEFVITVGSDRKISCFDGKSGE 240 ++ V ++P + +T G+D + + S Sbjct: 133 NGTTSPII-IDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDA 191 Query: 241 FLKYIEDDQEPVQGGIFALSWLDS----QKFATVGADATIRVWDVTTSKCVQKWTLDKQQ 296 +E E + ++W + A+V D T +W + K TL K++ Sbjct: 192 QTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEE 251 Query: 297 LG-NQQVGVVATGNGRIISLS-LDGTLNFYE 325 + + +G +++LS D + ++ Sbjct: 252 KFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 Score = 59.9 bits (143), Expect = 3e-09, Method: Composition-based stats. Identities = 45/291 (15%), Positives = 95/291 (32%), Gaps = 32/291 (10%) Query: 244 YIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVT--TSKCVQKWTLDKQQLGNQQ 301 E + + ++ AT +D TI++++V T K + T + + Sbjct: 4 IANAHNELIHDAVLDYY---GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVD 60 Query: 302 VGVVATGNGRIISLSLDGTLNFYELGHDE--VLKTISGHNKGITALTVNP------LISG 353 + S S DG + ++ + + + H+ + ++ P L+ Sbjct: 61 WA-HPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVA 119 Query: 354 SYDGRIME-------WSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFG 406 S DG++ +S + H+ + S + A + T + Sbjct: 120 SSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGAD 179 Query: 407 SQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEG 466 + K+ N+D T VL + + +V L S ++VS + + ++ Sbjct: 180 NLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRT-CIIWTQDN 238 Query: 467 NTIQVFK--LSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLY 515 K L + + L S S S +A K+ L+ Sbjct: 239 EQGPWKKTLLKEEKFPDVLW--------RASWSLSGNVLALSGGDNKVTLW 281 Score = 59.6 bits (142), Expect = 4e-09, Method: Composition-based stats. Identities = 39/277 (14%), Positives = 103/277 (37%), Gaps = 27/277 (9%) Query: 309 NGRIISLSLDGTLNFYELG--HDEVLKTISGHNKGITALT-VNP-----LISGSYDGRIM 360 R+ + S D T+ +E+ +++ T++GH + + +P L S SYDG+++ Sbjct: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 Query: 361 EWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFT 420 W ++ +++ + +S+ W + + V +G T Sbjct: 81 IW----KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTT 136 Query: 421 AVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVS 480 + + D + + S + + G ++ V N ++++K + + Sbjct: 137 SPIIIDAHAIGVNSASW---APATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQT 193 Query: 481 FDLKTPLRAKPSYI---SISPS---ETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKI 534 + L++ L ++ + SP+ +Y+A+ +++ + + + K Sbjct: 194 YVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKF 253 Query: 535 NAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVK 571 + W+ A+ L +G D + ++ Sbjct: 254 PDVLWR-----ASWSLSGNVLALSGG-DNKVTLWKEN 284 Score = 44.9 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 30/129 (23%), Positives = 51/129 (39%), Gaps = 28/129 (21%) Query: 500 ETYIAAGDVMGKILLY-DLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVAT 558 T +A+ GK+L++ + R + + A H++ +N++ W P E G L+ Sbjct: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGP--------LLLV 118 Query: 559 GSLDTNIFIYSVKR---PMKIIKALNAHKDGVNNLLWETPS--------------TLVSS 601 S D + + K II +A GVN+ W + V+ Sbjct: 119 ASSDGKVSVVEFKENGTTSPIIIDAHAI--GVNSASWAPATIEEDGEHNGTKESRKFVTG 176 Query: 602 GADACIKRW 610 GAD +K W Sbjct: 177 GADNLVKIW 185 Score = 38.8 bits (88), Expect = 0.008, Method: Composition-based stats. Identities = 16/95 (16%), Positives = 35/95 (36%), Gaps = 10/95 (10%) Query: 500 ETYIAAGDVMGKILLYDLQSREVK-TSRWAFHTSKINAISWKPAEKGANEEEIEEDLVAT 558 +A I +++++ K H + + W + G ++A+ Sbjct: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGT--------ILAS 72 Query: 559 GSLDTNIFIYSVKRPMKIIKALNA-HKDGVNNLLW 592 S D + I+ + A++A H VN++ W Sbjct: 73 CSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQW 107 >5A31-R nrPDB Length = 386 Score = 70.7 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 41/251 (16%), Positives = 94/251 (37%), Gaps = 26/251 (10%) Query: 122 ISWDFEGRRLCVVGEGRDNFGVFISWD--SGNSLGEVSGHSQRINACHLKQSRPMRSMTV 179 +SW G L V G+ +D + +SGH R+ + Sbjct: 137 LSWIGAGSHLAVGQAN----GLVEIYDVMKRKCIRTLSGHIDRVACLSW---NNHVLTSG 189 Query: 180 GDDGSVVFYQGP-PFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKS 238 D ++ P F + +H ++ V ++++ + + G+D + ++G S Sbjct: 190 SRDHRILHRDVRMPDPFFETIESHTQE---VCGLKWNVAD-NKLASGGNDNVVHVYEGTS 245 Query: 239 GEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLG 298 + ++ + V+ ++ AD +++W+V TS + G Sbjct: 246 KSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTS-----IKMSDIDSG 300 Query: 299 NQQVGVVATGNGRIISLSLDGT---LNFYELGHDEVLKTISGHNKGITALTVN----PLI 351 +Q +V + N + S + L ++ + + + GH+ + LT++ ++ Sbjct: 301 SQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVV 360 Query: 352 SGSYDGRIMEW 362 SG+ D + W Sbjct: 361 SGAGDETLRYW 371 Score = 59.9 bits (143), Expect = 3e-09, Method: Composition-based stats. Identities = 46/314 (14%), Positives = 94/314 (29%), Gaps = 53/314 (16%) Query: 14 PSTQRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFS 73 PS +F L +T+ +A GKS F+ D+ VV + + S Sbjct: 87 PSLADDFYYSLIDWSSTDVLAVALGKSIFL-----TDNNTGDVVHLCDTENEYTS---LS 138 Query: 74 PIKGSQYLCSGDESGKVIVWGWTFDKESNSVEV--------------------------- 106 I +L G +G V ++ K ++ Sbjct: 139 WIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWNNHVLTSGSRDHRILHR 198 Query: 107 ------NVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHS 160 + + + W+ +L G DN S + + H Sbjct: 199 DVRMPDPFFETIESHTQEVCGLKWNVADNKL--ASGGNDNVVHVYEGTSKSPILTFDEHK 256 Query: 161 QRINACHLKQSRPMRSMTVGD--DGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDS 218 + A + T G D + + + + GS + ++ +S ++ Sbjct: 257 AAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNT----SIKMSDIDSGSQICNMVWSKNT 312 Query: 219 GEFVITVGSDR-KISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIR 277 E V + G + ++ +D S + + ++ V + D + D T+R Sbjct: 313 NELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSN---DGTTVVSGAGDETLR 369 Query: 278 VWDVTTSKCVQKWT 291 W + + +T Sbjct: 370 YWKLFDVSVLNLFT 383 Score = 51.1 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 49/305 (16%), Positives = 101/305 (33%), Gaps = 45/305 (14%) Query: 222 VITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWL-DSQKFATVGADATIRVWD 280 V+ V + I D +G+ + + +LSW+ A A+ + ++D Sbjct: 105 VLAVALGKSIFLTDNNTGDVV-----HLCDTENEYTSLSWIGAGSHLAVGQANGLVEIYD 159 Query: 281 VTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDE-VLKTISGHN 339 V KC++ + +V ++ N + S S D + ++ + +TI H Sbjct: 160 VMKRKCIRTLSGH-----IDRVACLSWNNHVLTSGSRDHRILHRDVRMPDPFFETIESHT 214 Query: 340 KGITALTV----NPLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTL 395 + + L N L SG D + + +S +++D+ Sbjct: 215 QEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSP------------------ILTFDEHK 256 Query: 396 KVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLS 455 + +A+ T D L I T + + S + S Sbjct: 257 AAVKAMAWSPHKRGVLATGGG-------TADRRLKIWNVNTSIKMSDIDSGSQICNMVWS 309 Query: 456 QNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRA---KPSYISISPSETYIAAGDVMGKI 512 +N + G + L D S D L+ + ++++S T + +G + Sbjct: 310 KNTNELVTSHGYSKYNLTLWDCN-SMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETL 368 Query: 513 LLYDL 517 + L Sbjct: 369 RYWKL 373 Score = 48.4 bits (113), Expect = 9e-06, Method: Composition-based stats. Identities = 29/145 (20%), Positives = 56/145 (38%), Gaps = 23/145 (15%) Query: 463 LEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREV 522 L + NT V L D E + + +S + +++A G G + +YD+ R+ Sbjct: 116 LTDNNTGDVVHLCDTE----------NEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKC 165 Query: 523 KTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNA 582 + H ++ +SW ++ +GS D I V+ P + + + Sbjct: 166 -IRTLSGHIDRVACLSW------------NNHVLTSGSRDHRILHRDVRMPDPFFETIES 212 Query: 583 HKDGVNNLLWETPSTLVSSGADACI 607 H V L W ++SG + + Sbjct: 213 HTQEVCGLKWNVADNKLASGGNDNV 237 >5FA5-B nrPDB Length = 367 Score = 70.3 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 45/280 (16%), Positives = 92/280 (32%), Gaps = 21/280 (7%) Query: 92 VWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGN 151 +W + + + E + Q AG ++D++W E L G D Sbjct: 83 LWLFKDPCAAPN-EGFCSAGVQTEAG-VADLTWVGERGILVASDSGAVELWEL---DENE 137 Query: 152 SLGEVS----GHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGS 207 +L H ++ + S ++++ D + + +S R H Q Sbjct: 138 TLIVSKFCKYEHDDIVSTVSVLSSG-TQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQ-- 194 Query: 208 FVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKF 267 V V SP ++ D +I +D + + I A S+ F Sbjct: 195 -VTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVF 253 Query: 268 ATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELG 327 + T+ + D ++ CV + + + SLS D +L + Sbjct: 254 VFGDENGTVSLVDTKSTSCV--LSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSS 311 Query: 328 HDEVLKTISGHNKGITALTVNP-----LISGSYDGRIMEW 362 E+ ++ H + T +P L + +D +++ Sbjct: 312 LSELFRS-QAHRDFVRDATWSPLNHSLLTTVGWDHQVVHH 350 Score = 44.9 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 26/153 (16%), Positives = 58/153 (37%), Gaps = 18/153 (11%) Query: 460 AVGLEEGNTIQVFKLSDLE---VSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYD 516 + + +++++L + E VS K S +S+ S T +G I ++D Sbjct: 119 ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWD 178 Query: 517 LQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRP--- 573 L + V S + H +++ ++ P ++ + + S D I ++ + P Sbjct: 179 LAQQVV-LSSYRAHAAQVTCVAASP---------HKDSVFLSCSEDNRILLWDTRCPKPA 228 Query: 574 MKIIKALNAHKDGVNNLLWETPSTLVSSGADAC 606 +I + + +L W + V D Sbjct: 229 SQIGCSAPGYLPT--SLAWHPQQSEVFVFGDEN 259 Score = 43.8 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 36/231 (15%), Positives = 68/231 (29%), Gaps = 47/231 (20%) Query: 40 SAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDK 99 S V + +++ V +F + + + S + SG + + VW Sbjct: 125 SGAVELWELDENETLIVSKFCKYEHDDIVST-VSVLSSGTQAVSGSKDICIKVWDLAQQV 183 Query: 100 ESNSVEVNVKSEFQVLAGPISD-------------------------------------I 122 +S + V A P D + Sbjct: 184 VLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSL 243 Query: 123 SWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSG--HSQRINACHLKQSRPMRSMTVG 180 +W + + V G D G D+ ++ +S HSQ + ++ Sbjct: 244 AWHPQQSEVFVFG---DENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLS 300 Query: 181 DDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKI 231 +D S+ + FVRD +SP + + TVG D ++ Sbjct: 301 EDCSLAVLD----SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 347 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 24/122 (19%), Positives = 47/122 (38%), Gaps = 15/122 (12%) Query: 302 VGVVATGNGRIISLSLDGTLNFYELGHDEVLKTIS----GHNKGITALTV----NPLISG 353 + G I+ S G + +EL +E L H+ ++ ++V +SG Sbjct: 109 ADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSG 168 Query: 354 SYDGRIMEWSS-----SSMHQDHSNLIVSLDNSKAQE--YSSISWDDTLKVNGITKHEFG 406 S D I W S ++ H+ + + S ++ + S S D+ + + + Sbjct: 169 SKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPA 228 Query: 407 SQ 408 SQ Sbjct: 229 SQ 230 >4BH6-A nrPDB Length = 308 Score = 70.0 bits (169), Expect = 3e-12, Method: Composition-based stats. Identities = 41/251 (16%), Positives = 94/251 (37%), Gaps = 26/251 (10%) Query: 122 ISWDFEGRRLCVVGEGRDNFGVFISWD--SGNSLGEVSGHSQRINACHLKQSRPMRSMTV 179 +SW G L V G+ +D + +SGH R+ + Sbjct: 68 LSWIGAGSHLAVGQAN----GLVEIYDVMKRKCIRTLSGHIDRVACLSW---NNHVLTSG 120 Query: 180 GDDGSVVFYQGP-PFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKS 238 D ++ P F + +H ++ V ++++ + + G+D + ++G S Sbjct: 121 SRDHRILHRDVRMPDPFFETIESHTQE---VCGLKWNVAD-NKLASGGNDNVVHVYEGTS 176 Query: 239 GEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLG 298 + ++ + V+ ++ AD +++W+V TS + G Sbjct: 177 KSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTS-----IKMSDIDSG 231 Query: 299 NQQVGVVATGNGRIISLSLDGT---LNFYELGHDEVLKTISGHNKGITALTVN----PLI 351 +Q +V + N + S + L ++ + + + GH+ + LT++ ++ Sbjct: 232 SQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVV 291 Query: 352 SGSYDGRIMEW 362 SG+ D + W Sbjct: 292 SGAGDETLRYW 302 Score = 50.3 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 48/308 (15%), Positives = 102/308 (33%), Gaps = 45/308 (14%) Query: 222 VITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWL-DSQKFATVGADATIRVWD 280 V+ V + I D +G+ + + +LSW+ A A+ + ++D Sbjct: 36 VLAVALGKSIFLTDNNTGDVV-----HLCDTENEYTSLSWIGAGSHLAVGQANGLVEIYD 90 Query: 281 VTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDE-VLKTISGHN 339 V KC++ + +V ++ N + S S D + ++ + +TI H Sbjct: 91 VMKRKCIRTLSGH-----IDRVACLSWNNHVLTSGSRDHRILHRDVRMPDPFFETIESHT 145 Query: 340 KGI----TALTVNPLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTL 395 + + + N L SG D + + +S +++D+ Sbjct: 146 QEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSP------------------ILTFDEHK 187 Query: 396 KVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLS 455 + +A+ T D L I T + + S + S Sbjct: 188 AAVKAMAWSPHKRGVLATGGG-------TADRRLKIWNVNTSIKMSDIDSGSQICNMVWS 240 Query: 456 QNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRA---KPSYISISPSETYIAAGDVMGKI 512 +N + G + L D S D L+ + ++++S T + +G + Sbjct: 241 KNTNELVTSHGYSKYNLTLWDCN-SMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETL 299 Query: 513 LLYDLQSR 520 + L + Sbjct: 300 RYWKLFDK 307 Score = 48.0 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 29/145 (20%), Positives = 56/145 (38%), Gaps = 23/145 (15%) Query: 463 LEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREV 522 L + NT V L D E + + +S + +++A G G + +YD+ R+ Sbjct: 47 LTDNNTGDVVHLCDTE----------NEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKC 96 Query: 523 KTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNA 582 + H ++ +SW ++ +GS D I V+ P + + + Sbjct: 97 -IRTLSGHIDRVACLSW------------NNHVLTSGSRDHRILHRDVRMPDPFFETIES 143 Query: 583 HKDGVNNLLWETPSTLVSSGADACI 607 H V L W ++SG + + Sbjct: 144 HTQEVCGLKWNVADNKLASGGNDNV 168 >3BG0-A nrPDB Length = 316 Score = 68.4 bits (165), Expect = 9e-12, Method: Composition-based stats. Identities = 39/266 (14%), Positives = 78/266 (29%), Gaps = 30/266 (11%) Query: 37 CGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWT 96 C V+ D + + GH V P+ G+ L S KVI+W Sbjct: 31 CSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGN-ILASCSYDRKVIIW--- 86 Query: 97 FDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWD---SGNSL 153 + E ++ + W L + D +++ Sbjct: 87 ---REENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVK 143 Query: 154 GEVSGHSQRINAC-------------HLKQSRPM---RSMTVGDDGSVVFYQGPPFKFSA 197 + H+ NA H +P R + G D + ++ Sbjct: 144 KINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWK 203 Query: 198 SDRTHHKQGSFVRDVEFSPDSG---EFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQG 254 ++ +VRDV ++P G + + D ++ + + Sbjct: 204 EEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFND 263 Query: 255 GIFALSW-LDSQKFATVGADATIRVW 279 ++ +SW + + A G D + +W Sbjct: 264 VVWHVSWSITANILAVSGGDNKVTLW 289 Score = 66.1 bits (159), Expect = 4e-11, Method: Composition-based stats. Identities = 46/271 (16%), Positives = 101/271 (37%), Gaps = 25/271 (9%) Query: 264 SQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRII-SLSLDGTLN 322 + AT +D +++++DV + L + QV G I+ S S D + Sbjct: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 84 Query: 323 FYELGHD--EVLKTISGHNKGITALTVNP------LISGSYDGRIMEWSSSSMHQDHSNL 374 + + E +GH+ + ++ P L GS DG I S + + Sbjct: 85 IWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAI---SLLTYTGEGQWE 141 Query: 375 IVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVAS-ANNDGFTAVLTNDDDLLILQ 433 + ++N+ +++SW + + H G +P + G ++ + Q Sbjct: 142 VKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQ 201 Query: 434 SFTGDIIKS----VRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTP--- 486 +++ VR + ++ L + +A ++G +VF + + S + +P Sbjct: 202 WKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDG---RVFIWTCDDASSNTWSPKLL 258 Query: 487 --LRAKPSYISISPSETYIAAGDVMGKILLY 515 ++S S + +A K+ L+ Sbjct: 259 HKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 Score = 54.5 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 49/316 (15%), Positives = 108/316 (34%), Gaps = 65/316 (20%) Query: 309 NGRIISLSLDGTLNFYELGHDE--VLKTISGHNKGITALT-VNP-----LISGSYDGRIM 360 R+ + S D ++ +++ + ++ + GH + + +P L S SYD +++ Sbjct: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 84 Query: 361 EWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFT 420 W + + S+ D+S S+ W + + + Sbjct: 85 IWREENGTWEKSHEHAGHDSSVN----SVCW------------APHDYGLILACGSSDGA 128 Query: 421 AVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVS 480 L + + ++ +AVS + V L + + Q Sbjct: 129 ISLLTYTGEGQWEVKKINNAHTIG----CNAVSWAPAVVPGSLIDHPSGQ---------- 174 Query: 481 FDLKTPLRAKPSYISISPSETYIAAGDVMGKILLY--DLQSREVKTSRWAFHTSKINAIS 538 KP+YI A+G I L+ + + + + H+ + ++ Sbjct: 175 ---------KPNYI------KRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVA 219 Query: 539 WKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKII---KALNAHKDGVNNLLWETP 595 W P+ + +A+ S D +FI++ K L+ D V ++ W Sbjct: 220 WAPS------IGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSIT 273 Query: 596 STLVS-SGADACIKRW 610 + +++ SG D + W Sbjct: 274 ANILAVSGGDNKVTLW 289 Score = 54.2 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 43/252 (17%), Positives = 75/252 (29%), Gaps = 41/252 (16%) Query: 203 HKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKY--IEDDQEPVQGGIFALS 260 + D + G + T SDR + FD ++G + + + PV +A Sbjct: 10 TSHEDMIHDAQMD-YYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHP 68 Query: 261 WLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIIS-LSLDG 319 A+ D + +W + V G I++ S DG Sbjct: 69 MY-GNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDG 127 Query: 320 TLNFY---ELGHDEVLKTISGHNKGITALTVNP---------------------LISGSY 355 ++ G EV K + H G A++ P SG Sbjct: 128 AISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGC 187 Query: 356 DGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASAN 415 D I W +D + + ++W ++ + +AS + Sbjct: 188 DNLIKLW---KEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGL---------PTSTIASCS 235 Query: 416 NDGFTAVLTNDD 427 DG + T DD Sbjct: 236 QDGRVFIWTCDD 247 Score = 39.9 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 38/187 (20%), Positives = 68/187 (36%), Gaps = 37/187 (19%) Query: 445 LNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIA 504 + + S ++ + G I + L E + A P Y +A Sbjct: 24 YGTRLATCSSDRSVKIFDVRNGGQILIADLRGHE--GPVWQVAWAHPMY------GNILA 75 Query: 505 AGDVMGKILLY-DLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDT 563 + K++++ + K+ A H S +N++ W P + G ++A GS D Sbjct: 76 SCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGL--------ILACGSSDG 127 Query: 564 --NIFIYSVKRPMKIIKALNAHKDGVNNLLWE---TPSTLV---------------SSGA 603 ++ Y+ + ++ K NAH G N + W P +L+ S G Sbjct: 128 AISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGC 187 Query: 604 DACIKRW 610 D IK W Sbjct: 188 DNLIKLW 194 >5BJS-A nrPDB Length = 605 Score = 67.6 bits (163), Expect = 2e-11, Method: Composition-based stats. Identities = 23/169 (13%), Positives = 51/169 (30%), Gaps = 15/169 (8%) Query: 126 FEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSV 185 + LC+ G + + G + GH IN + P + DD ++ Sbjct: 146 TDQPLLCIAGN--EGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTI 203 Query: 186 VFYQGPPFKFS---ASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCF------DG 236 + P + V F D+G +V++ G D+ I+ + + Sbjct: 204 RIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFH-DNGRYVLSAGHDQVINLWALPEFPNE 262 Query: 237 KSGEFLKYIEDDQEP---VQGGIFALSWLDSQKFATVGADATIRVWDVT 282 + + +++ + + TI +W + Sbjct: 263 HMEIPIVIYYPHFSSSEIHNNLVDCVAFYGDLILSRACHEDTIVLWRIE 311 Score = 56.9 bits (135), Expect = 3e-08, Method: Composition-based stats. Identities = 20/115 (17%), Positives = 38/115 (33%), Gaps = 7/115 (6%) Query: 307 TGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP-----LISGSYDGRIME 361 T + +G + Y + ++ +T+ GH GI L +P + S S D I Sbjct: 146 TDQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRI 205 Query: 362 WSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANN 416 WS + H+ V + + Y +S + + + Sbjct: 206 WSLAPEHEKQ--PCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPE 258 Score = 52.6 bits (124), Expect = 5e-07, Method: Composition-based stats. Identities = 20/120 (16%), Positives = 45/120 (37%), Gaps = 14/120 (11%) Query: 270 VGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRII-SLSLDGTLNFYEL-- 326 G + ++V++VT K + + + + N II S S D T+ + L Sbjct: 154 AGNEGNVKVYNVTEGKLYRTLVGHGGGIND---LATSPANPYIIASASDDTTIRIWSLAP 210 Query: 327 ----GHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQDHSNLIVSL 378 + GH+ + ++ + ++S +D I W+ +H + + + Sbjct: 211 EHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPEFPNEHMEIPIVI 270 Score = 37.2 bits (84), Expect = 0.021, Method: Composition-based stats. Identities = 26/119 (21%), Positives = 45/119 (37%), Gaps = 18/119 (15%) Query: 499 SETYIAAGDVMGKILLYDLQSREVKT-SRWAFHTSKINAISWKPAEKGANEEEIEEDLVA 557 + + G + +Y++ E K H IN ++ PA ++A Sbjct: 147 DQPLLCIAGNEGNVKVYNVT--EGKLYRTLVGHGGGINDLATSPA---------NPYIIA 195 Query: 558 TGSLDTNIFIYSV-----KRPMKIIKALNAHKDGVNNLLWETPSTLV-SSGADACIKRW 610 + S DT I I+S+ K+P I H + ++ + V S+G D I W Sbjct: 196 SASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLW 254 Score = 36.1 bits (81), Expect = 0.048, Method: Composition-based stats. Identities = 26/217 (11%), Positives = 65/217 (29%), Gaps = 25/217 (11%) Query: 19 NFTTHLSYDPTTNAIAYP-CGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKG 77 N + S DP T+ G V+ + + K+ GHG + + SP Sbjct: 135 NCASCWSKDPITDQPLLCIAGNEGNVKVYNVTEGKL--YRTLVGHGGGI-NDLATSPA-N 190 Query: 78 SQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEG 137 + S + + +W + E + E + + +++ GR + G Sbjct: 191 PYIIASASDDTTIRIWSLAPEHEKQPCVCILGGE--GHSYDLLSVAFHDNGRYVLSAGHD 248 Query: 138 RD-NFGVFISWDSGNS----------LGEVSGHSQRINACHLKQSRPMRSMT-VGDDGSV 185 + N + + + H+ ++ ++ + ++ Sbjct: 249 QVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAFYGD---LILSRACHEDTI 305 Query: 186 VFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFV 222 V ++ F +SD + + + + Sbjct: 306 VLWRIEGF---SSDDPIPGPLDAPTPTDMTKQTRSYF 339 >3ACP-A nrPDB Length = 417 Score = 66.9 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 46/303 (15%), Positives = 102/303 (33%), Gaps = 48/303 (15%) Query: 142 GVFISWDSGNSLG--EVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASD 199 G DS +L H I S + D + + K ++ Sbjct: 116 GDIKVLDSNFNLQREIDQAHVSEITKLKFFPSGEALI-SSSQDMQLKIWS---VKDGSNP 171 Query: 200 RTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFAL 259 RT + V D+ D G V++ D I ++ +G + + P G Sbjct: 172 RTLIGHRATVTDIAII-DRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGV---- 226 Query: 260 SWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDG 319 +I ++ V T + + + + K+ T +I+ + G Sbjct: 227 --------------NSIALF-VGTDRQLHEISTSKKNN-----LEFGTYGKYVIAGHVSG 266 Query: 320 TLNFYELGHDEVLKTISGH-NKGITALTV-----NPLISGSYDGRIMEWSSSSMHQ---- 369 + + + E + +LTV N + +G +G + +W S Sbjct: 267 VITVHNVFSKEQTIQLPSKFTCSCNSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVGE 326 Query: 370 ---DHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTND 426 + I ++ + + S +D ++K++ I+ + + + + T +++ND Sbjct: 327 FLINEGTPINNVYFAAGALFVSSGFDTSIKLDIIS----DPESERPAIEFETPTFLVSND 382 Query: 427 DDL 429 D++ Sbjct: 383 DEV 385 Score = 42.2 bits (97), Expect = 6e-04, Method: Composition-based stats. Identities = 36/266 (13%), Positives = 78/266 (29%), Gaps = 47/266 (17%) Query: 62 HGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISD 121 H S + T +KF P + L S + ++ +W D + ++D Sbjct: 135 HVSEI-TKLKFFP--SGEALISSSQDMQLKIWSVK-DGSNPRT-------LIGHRATVTD 183 Query: 122 ISWDFEGRRLCVVGEGRDNFGVFISWD--SGNSLGEVSGHSQRINACHLKQSRPMRSMTV 179 I+ GR + G W+ +G ++ + + Sbjct: 184 IAIIDRGRNVLSASLD----GTIRLWECGTGTTIHTFNRKENPHDGV------------- 226 Query: 180 GDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSG 239 S+ + G + H S ++EF G++VI I+ + S Sbjct: 227 ---NSIALFVGTDRQL------HEISTSKKNNLEFGT-YGKYVIAGHVSGVITVHNVFSK 276 Query: 240 EFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCV--QKWTLDKQQL 297 E + + ++ + + WD+ + +C + + + Sbjct: 277 EQTIQLPSKFT-CSCNSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVGEFLINEGTPI 335 Query: 298 GNQQVGVVATGNGRIISLSLDGTLNF 323 N V +S D ++ Sbjct: 336 NN----VYFAAGALFVSSGFDTSIKL 357 Score = 38.8 bits (88), Expect = 0.007, Method: Composition-based stats. Identities = 32/228 (14%), Positives = 71/228 (31%), Gaps = 26/228 (11%) Query: 22 THLSYDPTTNA-IAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQY 80 T L + P+ A I+ + + DG + + GH ++V + Sbjct: 140 TKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTLI----GHRATVTDIAIID---RGRN 192 Query: 81 LCSGDESGKVIVWGWTF--------DKESNSVEVNVKSEFQVLAGPISDISWDFEGRR-- 130 + S G + +W KE+ VN + F + +IS + Sbjct: 193 VLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALFVGTDRQLHEISTSKKNNLEF 252 Query: 131 -----LCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSV 185 + G V + ++ S + N+ + + ++G + Sbjct: 253 GTYGKYVIAGHVSGVITVHNVFSKEQTIQLPSKFTCSCNSLTVDGNNANYIYAGYENGML 312 Query: 186 VFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISC 233 + + + +G+ + +V F+ G ++ G D I Sbjct: 313 AQWDLRSPECPVGEF-LINEGTPINNVYFAA--GALFVSSGFDTSIKL 357 Score = 35.7 bits (80), Expect = 0.067, Method: Composition-based stats. Identities = 30/175 (17%), Positives = 63/175 (36%), Gaps = 17/175 (9%) Query: 419 FTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLE 478 + A L D L G + + L +G EG+ I+V S+ Sbjct: 69 YKARLDGHDFLFNTIIRDGSKMLKRADYTAVDTAKLQMRRFILGTTEGD-IKVLD-SNFN 126 Query: 479 VSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAIS 538 + ++ ++ + + PS + + ++ ++ ++ H + + I+ Sbjct: 127 LQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKD-GSNPRTLIGHRATVTDIA 185 Query: 539 WKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKI---IKALNAHKDGVNNL 590 ++G N V + SLD I ++ I + N H DGVN++ Sbjct: 186 --IIDRGRN--------VLSASLDGTIRLWECGTGTTIHTFNRKENPH-DGVNSI 229 >6CB1-s nrPDB Length = 569 Score = 66.9 bits (161), Expect = 3e-11, Method: Composition-based stats. Identities = 51/343 (14%), Positives = 103/343 (30%), Gaps = 43/343 (12%) Query: 49 GDSKVPPV---VQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVE 105 D + P+ + GH V T S +L +G + G V VW +E Sbjct: 182 KDLRPFPIRCSTIYAGHKGKVRT---LSIDPSGLWLATGSDDGTVRVWEILTGREVYRTT 238 Query: 106 VNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSG---NSLGEVSGHSQR 162 + E I I W+ + + +N + + G + G+ Sbjct: 239 LIDDEENPDY--HIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGF 296 Query: 163 INACHLKQSRPMRSMTVGDDG---------------SVVFYQGPPFKFSASDRTHH-KQG 206 + + DG V + P K D Sbjct: 297 GYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCK 356 Query: 207 SFVRDVEFSPDSGEFVITVGSDR---KISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLD 263 V+ + + G++ +TV D + + + + F Sbjct: 357 KTVKKLSWHR-KGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKP- 414 Query: 264 SQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNF 323 + +R++D+ S+ + L ++ + G+ +I+ S D + + Sbjct: 415 --QLFVCSQ-RYVRIYDL--SQQILVKKLLPGARWLSKIDIHPRGD-NLIASSFDKRVLW 468 Query: 324 YELGHDEVLK-TISGHNKGITALTVN---PLI-SGSYDGRIME 361 ++L T+ H K + ++ + PL S + DG I Sbjct: 469 HDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHV 511 Score = 51.1 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 76/446 (17%), Positives = 153/446 (34%), Gaps = 84/446 (18%) Query: 209 VRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFA 268 VR + + D + + S + + F + + V+ S L A Sbjct: 162 VRKNKLNIDPNSLIPELPSPKDLRPFPIR---CSTIYAGHKGKVRTLSIDPSGL---WLA 215 Query: 269 TVGADATIRVWDVTTSKCVQKWTL---DKQQLGNQQVGVVATGNGR--IISLSLDGTLNF 323 T D T+RVW++ T + V + TL ++ + + + + I+++++ ++ Sbjct: 216 TGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIEC-IEWNPDANNGILAVAVGENIHL 274 Query: 324 -------YELGHDEVLKTISGH------NKGITALTVNPLISGSYDG-----------RI 359 Y++ ++ K G + L VN G DG ++ Sbjct: 275 IVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQV 334 Query: 360 MEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGF 419 +W+ S Q ++ +++ S + +SW K + + S N Sbjct: 335 AQWNKPSQKQLEKDICITI--SCKKTVKKLSW--HRKGDYFVTVQPDS------GNTSVL 384 Query: 420 TAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEV 479 ++ + G I+ + SQ YV ++ DL Sbjct: 385 IHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYV-------------RIYDLSQ 431 Query: 480 SFDLKTPLRAK--PSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAI 537 +K L S I I P + A ++L +DL +H + ++ Sbjct: 432 QILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSV 491 Query: 538 SWKPAEKGANEEEIEEDLVATGSLDTNIFIYS-------VKRPMKI-IKALNAHKD---- 585 ++ + L ++ + D I ++ +K PM + +K L HK Sbjct: 492 NF----------HKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSL 541 Query: 586 GVNNLLWE-TPSTLVSSGADACIKRW 610 GV + +W + L S+GAD + W Sbjct: 542 GVLDAIWHPREAWLFSAGADNTARLW 567 >6F1U-h nrPDB Length = 612 Score = 65.7 bits (158), Expect = 6e-11, Method: Composition-based stats. Identities = 53/327 (16%), Positives = 102/327 (31%), Gaps = 24/327 (7%) Query: 15 STQRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVV---TTVK 71 S+Q SY+ +A P G + + K P F H S V T K Sbjct: 262 SSQYPELLVASYNNNEDAPHEPDGVAL---VWNMKYKKTTPEYVF--HCQSAVMSATFAK 316 Query: 72 FSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRL 131 F P + G SG++++W +K + + + ++ L Sbjct: 317 FHP----NLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNL 372 Query: 132 CVVGEGRDNFGVFISWDSGNSLGEVSGHSQ----RINACHLKQSRPMRSMTVGDDGSVVF 187 + + S H Q + + + ++GSV Sbjct: 373 ISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYT 432 Query: 188 YQGPPFKFSASDR--THHKQGSFVRD--VEFSPDSGEFVITVGSDRKISCFDGKSGEFLK 243 K S+ H + + + D +T D + + K+ + L Sbjct: 433 ACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTKNNKPLY 492 Query: 244 YIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVG 303 ED+ V +++ + FA V + +W++ V ++ + Sbjct: 493 SFEDNAGYVYDVMWSPTHPAL--FACVDGMGRLDLWNLNNDTEVPTASISVEGNPALN-R 549 Query: 304 VVATGNGR-IISLSLDGTLNFYELGHD 329 V T +GR I +G + Y++G Sbjct: 550 VRWTHSGREIAVGDSEGQIVIYDVGEQ 576 Score = 56.1 bits (133), Expect = 5e-08, Method: Composition-based stats. Identities = 27/211 (12%), Positives = 64/211 (30%), Gaps = 27/211 (12%) Query: 182 DGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEF 241 DG + + +K + + H Q + V F+ V+ +I +D +S + Sbjct: 284 DGVALVW-NMKYKKTTPEYVFHCQSA-VMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKR 341 Query: 242 L------KYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSK----CVQKWT 291 PV + ++ ++ D I W + ++ Sbjct: 342 TPVQRTPLSAAAHTHPVYCVN-VVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVH 400 Query: 292 LDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDE---VLKTISGHNKGITALTVN 348 + + + + S +G++ H + + GH IT + + Sbjct: 401 KQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYT-ACRHGSKAGISEMFEGHQGPITGIHCH 459 Query: 349 P----------LISGSYDGRIMEWSSSSMHQ 369 ++ S+D + WS+ + Sbjct: 460 AAVGAVDFSHLFVTSSFDWTVKLWSTKNNKP 490 Score = 55.7 bits (132), Expect = 6e-08, Method: Composition-based stats. Identities = 52/422 (12%), Positives = 131/422 (31%), Gaps = 49/422 (11%) Query: 47 DDGDSKVPPVVQFTGHGSSVVTTVKF-SPIKGSQYLCSGDESGKVIVWGWTFDKESNSVE 105 ++ DSK PP ++ + +F S S + S ++ ++ ++ E Sbjct: 171 EENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIFFDYSGRDLEDKE 230 Query: 106 VNVKSEFQVLAGP------------ISDISWDFEGRRLCVVGEG------RDNFGVFISW 147 +++ ++ +S + W + L V + GV + W Sbjct: 231 GEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVW 290 Query: 148 D---SGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRT--- 201 + + V + + + P + G +V + K + RT Sbjct: 291 NMKYKKTTPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLS 350 Query: 202 HHKQGSFVRDV-EFSPDSGEFVITVGSDRKISCF--DGKSGEFLKYIEDDQEPVQGGIFA 258 V V + +I++ +D KI + D S ++ + + Sbjct: 351 AAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTS 410 Query: 259 LSWL--DSQKFATVGADATIRVWDVTTSKCV---QKWTLDKQQLGNQQVGVVATG---NG 310 +S+ D F + ++ + + + + + Sbjct: 411 MSFPVGDVNNFVVGSEEGSVYT-ACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSH 469 Query: 311 RIISLSLDGTLNFYELGHDEVLKTISGHNKGITALT---VNPLISGSYD--GRIMEWSSS 365 ++ S D T+ + +++ L + + + + +P + D GR+ W+ + Sbjct: 470 LFVTSSFDWTVKLWSTKNNKPLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLN 529 Query: 366 SMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTN 425 D S+ + + W + + + S+ ++ + AV N Sbjct: 530 ---NDTEVPTASISVEGNPALNRVRWTHSGREIAVG----DSEGQIVIYDVGEQIAVPRN 582 Query: 426 DD 427 D+ Sbjct: 583 DE 584 >5A9Q-0 nrPDB Length = 380 Score = 65.7 bits (158), Expect = 6e-11, Method: Composition-based stats. Identities = 43/271 (15%), Positives = 94/271 (34%), Gaps = 24/271 (8%) Query: 123 SWDFEGRRLCVVG-EGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGD 181 SWD E + + N ++ + L H + R + Sbjct: 36 SWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCDIRHHGDVMDLQFFDQE--RIVAASS 93 Query: 182 DGSVVFY----QGPPFKFSASDRTHHKQGSFVRDVEFSPD------SGEFVITVGSDRKI 231 G V + + T H S + ++TVG D +I Sbjct: 94 TGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTGVVCNNPEIVTVGEDGRI 153 Query: 232 SCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTT--SKCVQK 289 + F E ++ I++ + A+++L + + TV + +++WD ++ Q Sbjct: 154 NLFRADHKEAVRTIDN---ADSSTLHAVTFLRTPEILTVNSIGQLKIWDFRQQGNEPSQI 210 Query: 290 WTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEV-LKTISGHNKGITALTVN 348 +L ++ V + + DG L+ +++ + + + H + + + Sbjct: 211 LSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVHFH 270 Query: 349 P-----LISGSYDGRIMEWSSSSMHQDHSNL 374 P L + S DG + W +S+ + S+L Sbjct: 271 PSNPEHLFTCSEDGSLWHWDASTDVPEKSSL 301 Score = 65.3 bits (157), Expect = 7e-11, Method: Composition-based stats. Identities = 43/266 (16%), Positives = 85/266 (31%), Gaps = 27/266 (10%) Query: 115 LAGPISDISWDFEGRRLCVVGEG-------RDNFGVFISWDSGNSLGEVSGHSQRINA-- 165 G + D+ + + R + G N + +G + Sbjct: 73 HHGDVMDLQFFDQERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSA 132 Query: 166 -CHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTH-HKQGSFVRDVEFSPDSGEFVI 223 C +TVG+DG + ++ + RT + S + V F ++ Sbjct: 133 PCTGVVCNNPEIVTVGEDGRINLFRADH---KEAVRTIDNADSSTLHAVTFLR--TPEIL 187 Query: 224 TVGSDRKISCFDGKSG----EFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVW 279 TV S ++ +D + + + D+ P+ + AT G D + +W Sbjct: 188 TVNSIGQLKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPN--QQHVVATGGQDGMLSIW 245 Query: 280 DVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHN 339 DV + L + +V + + + S DG+L ++ D K+ H Sbjct: 246 DVRQGT-MPVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQ 304 Query: 340 KGITALTVNPLISGSYDGRIMEWSSS 365 G + +S S + S Sbjct: 305 GG----RSSTFLSHSISNQANVHQSV 326 Score = 58.0 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 31/247 (12%), Positives = 73/247 (29%), Gaps = 19/247 (7%) Query: 77 GSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGE 136 + + + +G V V + + ++ VN + S+ V Sbjct: 84 DQERIVAASSTGCVTV--FLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTGVVC-- 139 Query: 137 GRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQS---------RPMRSMTVGDDGSVVF 187 +N + + G + H + + S R +TV G + Sbjct: 140 --NNPEIVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSIGQLKI 197 Query: 188 YQ-GPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGE-FLKYI 245 + + + + V+ P+ V T G D +S +D + G + + Sbjct: 198 WDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLL 257 Query: 246 EDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVV 305 + + + F S + T D ++ WD +T + + + + Sbjct: 258 KAHEAEMWEVHFHPSNP--EHLFTCSEDGSLWHWDASTDVPEKSSLFHQGGRSSTFLSHS 315 Query: 306 ATGNGRI 312 + + Sbjct: 316 ISNQANV 322 Score = 34.1 bits (76), Expect = 0.16, Method: Composition-based stats. Identities = 39/283 (13%), Positives = 95/283 (33%), Gaps = 37/283 (13%) Query: 346 TVNPLISGSYDG---RIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNG-IT 401 T +GS+D I WS +S ++ +G + Sbjct: 28 TAETFATGSWDNEENYISLWSIGD---------FGNLDSDGGFEGDHQLLCDIRHHGDVM 78 Query: 402 KHEFGSQPKVASANNDGFTAVLTNDDDLLILQ--------SFTGDIIKSVRLNSPGSAVS 453 +F Q ++ +A++ G V + + L + ++P + V Sbjct: 79 DLQFFDQERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTGVV 138 Query: 454 LSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKIL 513 + + E+G I +F+ E + + ++ + + + G++ Sbjct: 139 CNNPEIVTVGEDG-RINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSI-GQLK 196 Query: 514 LYDLQ---SREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSV 570 ++D + + + ++ + P ++ +VATG D + I+ V Sbjct: 197 IWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQH---------VVATGGQDGMLSIWDV 247 Query: 571 KRPMKIIKALNAHKDGVNNLLW--ETPSTLVSSGADACIKRWN 611 ++ + L AH+ + + + P L + D + W+ Sbjct: 248 RQGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWD 290 >6EM1-m nrPDB Length = 807 Score = 65.7 bits (158), Expect = 6e-11, Method: Composition-based stats. Identities = 51/343 (14%), Positives = 103/343 (30%), Gaps = 43/343 (12%) Query: 49 GDSKVPPV---VQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVE 105 D + P+ + GH V T S +L +G + G V VW +E Sbjct: 420 KDLRPFPIRCSTIYAGHKGKVRT---LSIDPSGLWLATGSDDGTVRVWEILTGREVYRTT 476 Query: 106 VNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSG---NSLGEVSGHSQR 162 + E I I W+ + + +N + + G + G+ Sbjct: 477 LIDDEENPDY--HIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGF 534 Query: 163 INACHLKQSRPMRSMTVGDDG---------------SVVFYQGPPFKFSASDRTHH-KQG 206 + + DG V + P K D Sbjct: 535 GYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCK 594 Query: 207 SFVRDVEFSPDSGEFVITVGSDR---KISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLD 263 V+ + + G++ +TV D + + + + F Sbjct: 595 KTVKKLSWHR-KGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKP- 652 Query: 264 SQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNF 323 + +R++D+ S+ + L ++ + G+ +I+ S D + + Sbjct: 653 --QLFVCSQ-RYVRIYDL--SQQILVKKLLPGARWLSKIDIHPRGD-NLIASSFDKRVLW 706 Query: 324 YELGHDEVLK-TISGHNKGITALTVN---PLI-SGSYDGRIME 361 ++L T+ H K + ++ + PL S + DG I Sbjct: 707 HDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHV 749 Score = 49.9 bits (117), Expect = 4e-06, Method: Composition-based stats. Identities = 76/446 (17%), Positives = 153/446 (34%), Gaps = 84/446 (18%) Query: 209 VRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFA 268 VR + + D + + S + + F + + V+ S L A Sbjct: 400 VRKNKLNIDPNSLIPELPSPKDLRPFPIR---CSTIYAGHKGKVRTLSIDPSGL---WLA 453 Query: 269 TVGADATIRVWDVTTSKCVQKWTL---DKQQLGNQQVGVVATGNGR--IISLSLDGTLNF 323 T D T+RVW++ T + V + TL ++ + + + + I+++++ ++ Sbjct: 454 TGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIEC-IEWNPDANNGILAVAVGENIHL 512 Query: 324 -------YELGHDEVLKTISGH------NKGITALTVNPLISGSYDG-----------RI 359 Y++ ++ K G + L VN G DG ++ Sbjct: 513 IVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQV 572 Query: 360 MEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGF 419 +W+ S Q ++ +++ S + +SW K + + S N Sbjct: 573 AQWNKPSQKQLEKDICITI--SCKKTVKKLSW--HRKGDYFVTVQPDS------GNTSVL 622 Query: 420 TAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEV 479 ++ + G I+ + SQ YV ++ DL Sbjct: 623 IHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYV-------------RIYDLSQ 669 Query: 480 SFDLKTPLRAK--PSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAI 537 +K L S I I P + A ++L +DL +H + ++ Sbjct: 670 QILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSV 729 Query: 538 SWKPAEKGANEEEIEEDLVATGSLDTNIFIYS-------VKRPMKI-IKALNAHKD---- 585 ++ + L ++ + D I ++ +K PM + +K L HK Sbjct: 730 NF----------HKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSL 779 Query: 586 GVNNLLWE-TPSTLVSSGADACIKRW 610 GV + +W + L S+GAD + W Sbjct: 780 GVLDAIWHPREAWLFSAGADNTARLW 805 >6C0F-s nrPDB Length = 807 Score = 65.3 bits (157), Expect = 7e-11, Method: Composition-based stats. Identities = 51/343 (14%), Positives = 103/343 (30%), Gaps = 43/343 (12%) Query: 49 GDSKVPPV---VQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVE 105 D + P+ + GH V T S +L +G + G V VW +E Sbjct: 420 KDLRPFPIRCSTIYAGHKGKVRT---LSIDPSGLWLATGSDDGTVRVWEILTGREVYRTT 476 Query: 106 VNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSG---NSLGEVSGHSQR 162 + E I I W+ + + +N + + G + G+ Sbjct: 477 LIDDEENPDY--HIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGF 534 Query: 163 INACHLKQSRPMRSMTVGDDG---------------SVVFYQGPPFKFSASDRTHH-KQG 206 + + DG V + P K D Sbjct: 535 GYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCK 594 Query: 207 SFVRDVEFSPDSGEFVITVGSDR---KISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLD 263 V+ + + G++ +TV D + + + + F Sbjct: 595 KTVKKLSWHR-KGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKP- 652 Query: 264 SQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNF 323 + +R++D+ S+ + L ++ + G+ +I+ S D + + Sbjct: 653 --QLFVCSQ-RYVRIYDL--SQQILVKKLLPGARWLSKIDIHPRGD-NLIASSFDKRVLW 706 Query: 324 YELGHDEVLK-TISGHNKGITALTVN---PLI-SGSYDGRIME 361 ++L T+ H K + ++ + PL S + DG I Sbjct: 707 HDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHV 749 Score = 49.5 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 76/446 (17%), Positives = 153/446 (34%), Gaps = 84/446 (18%) Query: 209 VRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFA 268 VR + + D + + S + + F + + V+ S L A Sbjct: 400 VRKNKLNIDPNSLIPELPSPKDLRPFPIR---CSTIYAGHKGKVRTLSIDPSGL---WLA 453 Query: 269 TVGADATIRVWDVTTSKCVQKWTL---DKQQLGNQQVGVVATGNGR--IISLSLDGTLNF 323 T D T+RVW++ T + V + TL ++ + + + + I+++++ ++ Sbjct: 454 TGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIEC-IEWNPDANNGILAVAVGENIHL 512 Query: 324 -------YELGHDEVLKTISGH------NKGITALTVNPLISGSYDG-----------RI 359 Y++ ++ K G + L VN G DG ++ Sbjct: 513 IVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQV 572 Query: 360 MEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGF 419 +W+ S Q ++ +++ S + +SW K + + S N Sbjct: 573 AQWNKPSQKQLEKDICITI--SCKKTVKKLSW--HRKGDYFVTVQPDS------GNTSVL 622 Query: 420 TAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEV 479 ++ + G I+ + SQ YV ++ DL Sbjct: 623 IHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYV-------------RIYDLSQ 669 Query: 480 SFDLKTPLRAK--PSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAI 537 +K L S I I P + A ++L +DL +H + ++ Sbjct: 670 QILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSV 729 Query: 538 SWKPAEKGANEEEIEEDLVATGSLDTNIFIYS-------VKRPMKI-IKALNAHKD---- 585 ++ + L ++ + D I ++ +K PM + +K L HK Sbjct: 730 NF----------HKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSL 779 Query: 586 GVNNLLWE-TPSTLVSSGADACIKRW 610 GV + +W + L S+GAD + W Sbjct: 780 GVLDAIWHPREAWLFSAGADNTARLW 805 >4OWR-A nrPDB Length = 339 Score = 64.9 bits (156), Expect = 1e-10, Method: Composition-based stats. Identities = 23/134 (17%), Positives = 43/134 (32%), Gaps = 10/134 (7%) Query: 163 INACHLKQSR--PMRSMTVGDDGSVVFYQGPP--FKFSASDRTHHKQGSFVRDVEFSPDS 218 I + V ++ + + H V DV +S D Sbjct: 13 IGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGP---VLDVCWS-DD 68 Query: 219 GEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRV 278 G V T D+ +D S + ++ + PV+ + + + T D T++ Sbjct: 69 GSKVFTASCDKTAKMWDLSSNQAIQIAQ-HDAPVKTIHW-IKAPNYSCVMTGSWDKTLKF 126 Query: 279 WDVTTSKCVQKWTL 292 WD +S + L Sbjct: 127 WDTRSSNPMMVLQL 140 Score = 50.3 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 21/123 (17%), Positives = 43/123 (34%), Gaps = 12/123 (9%) Query: 74 PIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCV 133 P +L +G + V W ++ + Q+ GP+ D+ W +G ++ Sbjct: 21 PTLPGNFLIAGSWANDVRCWEVQDSGQT------IPKAQQMHTGPVLDVCWSDDGSKVFT 74 Query: 134 VGEGRDNFGVFISWD-SGNSLGEVSGHSQRINACHLKQSRPMR-SMTVGDDGSVVFYQGP 191 + WD S N +++ H + H ++ MT D ++ F+ Sbjct: 75 ASCDK----TAKMWDLSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTR 130 Query: 192 PFK 194 Sbjct: 131 SSN 133 Score = 39.9 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 43/287 (14%), Positives = 71/287 (24%), Gaps = 76/287 (26%) Query: 43 VRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESN 102 VRC + DS H V+ + + +W Sbjct: 37 VRCWEVQDSGQTIPKAQQMHTGPVLDVC---WSDDGSKVFTASCDKTAKMW--------- 84 Query: 103 SVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSL--------- 153 + N + P+ I W CV+ D WD+ +S Sbjct: 85 DLSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWD--KTLKFWDTRSSNPMMVLQLPE 142 Query: 154 -------------------------------------GEVSGHSQRINACHLKQSRPMRS 176 + + + KQ++P Sbjct: 143 RCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHRCVAIFKDKQNKPTGF 202 Query: 177 MTVGDDGSVVFYQGPPFKFSASDRTHHKQGSF------------VRDVEFSPDSGEFVIT 224 +G V + P + + T S V + F P G + T Sbjct: 203 ALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVHG-TLAT 261 Query: 225 VGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVG 271 VGSD + S +D + LK E +P+ + FA Sbjct: 262 VGSDGRFSFWDKDARTKLKTSEQLDQPISA---CCFNHNGNIFAYAS 305 >6E29-D nrPDB Length = 345 Score = 64.6 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 53/336 (15%), Positives = 118/336 (35%), Gaps = 57/336 (16%) Query: 264 SQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGR-IISLSLDGTLN 322 A+ D T+ +WD+ T +K + + + + GR ++S + Sbjct: 37 GDFLASGRVDGTVVIWDLETMGVARKLRGHSKNIT----SLSWSRCGRYLLSACQGWKVI 92 Query: 323 FYELGHDEVLKTISGHNKGITALTVNPLISGSYDGRIMEWS----SSSMHQDHSNLIVSL 378 ++L + + + + ++P W+ ++++ +D L+ Sbjct: 93 LWDLQDGKRYREVR-FRAPVYGAELHP------------WNHHQFAAALFEDQPMLVDIT 139 Query: 379 DNSKAQEYS-------SISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLI 431 + + + S D L+ + + + T L I Sbjct: 140 EPVEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGDHLLAGTTKGRLNI 199 Query: 432 LQSFTGDIIKSVRLNS---PGSAVSLSQNYVAVGLEEG--NTIQVFKLSDLEVSFD-LKT 485 + + T +II S ++ S ++ S + V ++ T V LS ++ D ++ Sbjct: 200 IDARTREIIYSEKIASGIITTLRLTESGRELLVNAQDRIIRTFIVPNLSAADLDPDTIQL 259 Query: 486 PLRAKP---------SYISISPSETYIAAGDVMG-KILLYDLQSREVKTSRWAFHTSKIN 535 PL K ++++ S + Y+AA ++ +++ H S + Sbjct: 260 PLEHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIWE-----------RGHGSLVR 308 Query: 536 AISWKPAEKGANEEEIEEDLVATGSLDTN-IFIYSV 570 + E+G E L+A L+T I I+SV Sbjct: 309 MLEGPKEEQGVIEWHPHRALLAACGLETGRINIWSV 344 Score = 58.4 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 59/341 (17%), Positives = 105/341 (30%), Gaps = 59/341 (17%) Query: 60 TGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPI 119 +GH T V+F+ + +L SG G V++W + V + + + I Sbjct: 25 SGHS----TCVRFN--RKGDFLASGRVDGTVVIWDLE--------TMGVARKLRGHSKNI 70 Query: 120 SDISWDFEGRRLCVVGEGRDNFGVFISWD--SGNSLGEVSGHSQRINACHLKQSRPMRSM 177 + +SW GR L +G I WD G EV + L + Sbjct: 71 TSLSWSRCGRYLLSACQG----WKVILWDLQDGKRYREVR-FRAPVYGAELHPWNHHQFA 125 Query: 178 TV-GDDGSVVF---------YQGPPFKFSASDRTHHK--------QGSFVRDVEFSPDSG 219 +D ++ Y P S T + SG Sbjct: 126 AALFEDQPMLVDITEPVEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASG 185 Query: 220 EFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVW 279 + ++ + +++ D ++ E + + + S ++ D IR + Sbjct: 186 DHLLAGTTKGRLNIIDARTREIIYSEKIASGIITTLRLTES---GRELLVNAQDRIIRTF 242 Query: 280 DVTTSKCV------------QKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELG 327 V K+ +L V ATG S + L +E G Sbjct: 243 IVPNLSAADLDPDTIQLPLEHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIWERG 302 Query: 328 HDEVLKTISGHNKGITALTVNP-----LISGSYDGRIMEWS 363 H +++ + G + + +P G GRI WS Sbjct: 303 HGSLVRMLEGPKEEQGVIEWHPHRALLAACGLETGRINIWS 343 >5OQL-X nrPDB Length = 630 Score = 63.8 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 40/259 (15%), Positives = 73/259 (28%), Gaps = 58/259 (22%) Query: 154 GEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVE 213 GH + Q +T G D +V Y K + + V + Sbjct: 240 KTYQGHLKAPLVVKASQDGKF-VVTGGADKRLVVYNAADLK---PIKAFTQHRDAVTGLA 295 Query: 214 FSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGAD 273 F + + DR + + +++ + Q+ + + + + D Sbjct: 296 F-RRGTNQLYSCSKDRTVKVWSLDELAYVETLFGHQDEILDID---ALGQERCVSVGARD 351 Query: 274 ATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATG-------------------NGRIIS 314 T R W V + + N + + G + ++ Sbjct: 352 RTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAMIDDDMFVT 411 Query: 315 LSLDGTLNFYELGHDEVLKTI-SGHN--------------------------KGITALTV 347 S +G L + + + L I H +GITAL Sbjct: 412 GSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQPRGITALRT 471 Query: 348 NP----LISGSYDGRIMEW 362 P + SGS+DG I W Sbjct: 472 LPYSDLIFSGSWDGCIRVW 490 Score = 57.2 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 55/285 (19%), Positives = 95/285 (33%), Gaps = 30/285 (10%) Query: 243 KYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQV 302 K + + + D + T GAD + V++ K ++ +T + Sbjct: 240 KTYQGHLKAPLVVK---ASQDGKFVVTGGADKRLVVYNAADLKPIKAFTQHR---DAVTG 293 Query: 303 GVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKG---ITALTVNPLIS-GSYDGR 358 G ++ S S D T+ + L ++T+ GH I AL +S G+ D Sbjct: 294 LAFRRGTNQLYSCSKDRTVKVWSLDELAYVETLFGHQDEILDIDALGQERCVSVGARDRT 353 Query: 359 IMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDG 418 W + S L+ E S + K G P +A+ Sbjct: 354 ARYW----KVPEESQLV----FRGGGEGGSSNTKKH-------KLPPGMDPAS-AAHEGS 397 Query: 419 FTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLE 478 V DDD+ + S GD+ L S L A GLE ++ + ++ Sbjct: 398 MDRVAMIDDDMFVTGSDNGDL----ALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIP 453 Query: 479 VSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVK 523 + P + + P I +G G I ++ L + K Sbjct: 454 DPSIIPAPQPRGITALRTLPYSDLIFSGSWDGCIRVWRLSEDKRK 498 Score = 39.9 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 36/243 (14%), Positives = 66/243 (27%), Gaps = 61/243 (25%) Query: 44 RCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNS 103 R + + + P+ FT H VT + F +G+ L S + V VW Sbjct: 269 RLVVYNAADLKPIKAFTQHR-DAVTGLAFR--RGTNQLYSCSKDRTVKVWSLD------- 318 Query: 104 VEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVF--------ISWDSGNSLGE 155 E+ I DI D G+ CV RD + + + G G Sbjct: 319 -ELAYVETLFGHQDEILDI--DALGQERCVSVGARDRTARYWKVPEESQLVFRGGGEGGS 375 Query: 156 V---------------SGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDR 200 + H ++ + +T D+G + + K Sbjct: 376 SNTKKHKLPPGMDPASAAHEGSMDRVAMIDDD--MFVTGSDNGDLALWSIQRKKPLHVIA 433 Query: 201 THHKQGSFVRDVEFSPD-----------------------SGEFVITVGSDRKISCFDGK 237 H ++ ++S D + + + D I + Sbjct: 434 RAHGLEPPIKLEDYSADEIPDPSIIPAPQPRGITALRTLPYSDLIFSGSWDGCIRVWRLS 493 Query: 238 SGE 240 + Sbjct: 494 EDK 496 Score = 39.9 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 55/325 (16%), Positives = 110/325 (33%), Gaps = 53/325 (16%) Query: 339 NKGITALTVNP--LISGSYDGRIMEWSSSSMHQDH-------SNLIVSLDNSKAQEYSSI 389 + +T++ V P + + DG + +W + ++ K E Sbjct: 170 SGTVTSVAVCPPYAYTTTKDGYLTKWKLQDLPKNQWPQTTKKKPKKPPAPPKKRPERICF 229 Query: 390 SWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTN-DDDLLILQSFTGDIIKSVRLNS- 447 + D K N T P V A+ DG V D L++ + IK+ + Sbjct: 230 AKADARKANDKTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLKPIKAFTQHRD 289 Query: 448 --PGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAA 505 G A N + ++ T++V+ L +L L + + I E ++ Sbjct: 290 AVTGLAFRRGTNQLYSCSKD-RTVKVWSLDELAYVETLFGH-QDEILDIDALGQERCVSV 347 Query: 506 GDVMGKILLYDLQSR---------EVKTSRWAFHTSKINAISWKPAEKGANEE--EIEED 554 G + + E +S H A +G+ + I++D Sbjct: 348 GARDRTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAMIDDD 407 Query: 555 LVATGSLDTNIFIYSV--KRPMKIIKALNAHKDGVNNLLWETP----------------- 595 + TGS + ++ ++S+ K+P+ +I + + + + Sbjct: 408 MFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQPRGIT 467 Query: 596 -------STLVSSGA-DACIKRWNV 612 S L+ SG+ D CI+ W + Sbjct: 468 ALRTLPYSDLIFSGSWDGCIRVWRL 492 >5WLC-LN nrPDB Length = 776 Score = 63.8 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 77/448 (17%), Positives = 153/448 (34%), Gaps = 52/448 (11%) Query: 170 QSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDR 229 +R ++G V + R + + + + DS + + + Sbjct: 108 NGESLRLFSIGGSTVVTEWDLAT---GLPLRNYDCNSGVIWSISIN-DSQDKLSVGCDNG 163 Query: 230 KISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTT-----S 284 + D G + + + + L+W +D IR+W Sbjct: 164 TVVLIDISGGPGVLEHDTILMRQEARVLTLAWKKDDFVIGGCSDGRIRIWSAQKNDENMG 223 Query: 285 KCVQKWTLDKQQLGNQQV-GVVATGNG-RIISLSLDGTLNFYELGHDEVLKTISGHNKGI 342 + + +DK + + V V+ +I S G++ F++ + ++ H+ + Sbjct: 224 RLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAHDADV 283 Query: 343 TALTV----NPLISGSYDGRIME-------------WSSSSMHQDHSNLIVSLD---NSK 382 LT N + S D +I + W +SS H N I ++ + Sbjct: 284 LCLTTDTDNNYVFSAGVDRKIFQFSQNTNKSQKNNRWVNSSNRLLHGNDIRAICAYQSKG 343 Query: 383 AQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKS 442 A S + TL +N +T G+ K+ + VL N + L++ + Sbjct: 344 ADFLVSGGVEKTLVINSLTSFSNGNYRKMPTV-EPYSKNVLVNKEQRLVVSWSES----T 398 Query: 443 VRLNSPGSAVSLSQNYVAVG---LEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPS 499 V++ + G+ S QNY V L++ I LS + P K ++ P Sbjct: 399 VKIWTMGTDSSTEQNYKLVCKLTLKDDQNISTCSLSPDGQVLVVGRPSTTKVFHL--QPV 456 Query: 500 ETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPA------EKGANEEEIEE 553 + + +LL ++ VK SKI S + E +E+ E Sbjct: 457 GNKLKVTKLDNDLLL-RTSTKLVKF----IDNSKIVICSCEDDVFIVDLESEEDEKPQEV 511 Query: 554 DLVATGSLDTNIFIYSVKRPMKIIKALN 581 +L+ S ++I + + R + N Sbjct: 512 ELLEVTSTKSSIKVPYINRINHLEVDQN 539 Score = 41.8 bits (96), Expect = 9e-04, Method: Composition-based stats. Identities = 38/263 (14%), Positives = 92/263 (34%), Gaps = 24/263 (9%) Query: 81 LCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDN 140 + SGD +G + W + F + S F+ + ++ D + + G R Sbjct: 253 IASGDSTGSIKFWDFQFATLNQS--------FKAHDADVLCLTTDTDNNYVFSAGVDRKI 304 Query: 141 FGVFISWD-SGNSLGEVSGHSQRINA------CHLKQSRPMRSMTVGDDGSVVFYQGPPF 193 F + + S + V+ ++ ++ C + ++ G + ++V F Sbjct: 305 FQFSQNTNKSQKNNRWVNSSNRLLHGNDIRAICAYQSKGADFLVSGGVEKTLVINSLTSF 364 Query: 194 KFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCF----DGKSGEFLKYIEDDQ 249 + R + ++V + + + ++ S+ + + D + + K + Sbjct: 365 SNG-NYRKMPTVEPYSKNVLVNKE--QRLVVSWSESTVKIWTMGTDSSTEQNYKLVCKLT 421 Query: 250 EPVQGGIFALSWLDSQKFATVGADATIRVWDV-TTSKCVQKWTLDKQQLGNQQVGVV-AT 307 I S + VG +T +V+ + ++ LD L +V Sbjct: 422 LKDDQNISTCSLSPDGQVLVVGRPSTTKVFHLQPVGNKLKVTKLDNDLLLRTSTKLVKFI 481 Query: 308 GNGRIISLSLDGTLNFYELGHDE 330 N +I+ S + + +L +E Sbjct: 482 DNSKIVICSCEDDVFIVDLESEE 504 Score = 36.4 bits (82), Expect = 0.036, Method: Composition-based stats. Identities = 53/384 (13%), Positives = 115/384 (29%), Gaps = 97/384 (25%) Query: 231 ISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKW 290 D + + + A ++ I +W+ + Q+ Sbjct: 36 CRFVDFTPATITSLAFSHKSNINKLT-----PSDLRLAIGRSNGNIEIWNPRNNW-FQEM 89 Query: 291 TLDKQQLGNQQVGVVATGNG---RIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTV 347 ++ + + + + NG R+ S+ + ++L L+ ++ I ++++ Sbjct: 90 VIEGGKDRSIEGLCWSNVNGESLRLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISI 149 Query: 348 NP----LISGSYDGRIMEWSSS--SMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGIT 401 N L G +G ++ S +H +++ + +++W Sbjct: 150 NDSQDKLSVGCDNGTVVLIDISGGPGVLEHDTILM----RQEARVLTLAWKK-------- 197 Query: 402 KHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAV 461 DD +I G I S +N + Sbjct: 198 -------------------------DDFVIGGCSDGRI----------RIWSAQKNDENM 222 Query: 462 GLEEGNTIQVFKLSDLEV-SFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSR 520 G + K+ + S + + P IA+GD G I +D Q Sbjct: 223 ----GRLLHTMKVDKAKKESTLVW--------SVIYLPRTDQIASGDSTGSIKFWDFQFA 270 Query: 521 EVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKAL 580 + S + H + + ++ + + + V + +D IF +S Sbjct: 271 TLNQS-FKAHDADVLCLT----------TDTDNNYVFSAGVDRKIFQFSQ---------- 309 Query: 581 NAHKDGVNNLLWETPSTLVSSGAD 604 N +K NN W S + G D Sbjct: 310 NTNKSQKNN-RWVNSSNRLLHGND 332 >3JZG-A nrPDB Length = 402 Score = 63.0 bits (151), Expect = 4e-10, Method: Composition-based stats. Identities = 47/368 (12%), Positives = 96/368 (26%), Gaps = 61/368 (16%) Query: 43 VRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESN 102 V L + ++ VQF H V + L G++ + D +++ Sbjct: 46 VNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADAD 105 Query: 103 SVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQR 162 +D + G I+ + + GH Sbjct: 106 ENFYTCAWT------------YDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNA 153 Query: 163 INACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFV 222 IN P ++V D ++ + A V ++ GE + Sbjct: 154 INELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDL-LGEKI 212 Query: 223 ITVGSDRKISCFDGKSGEFLKYIE------------------------DDQEPVQGGIFA 258 ++ G D + + S + I+ ++ + + Sbjct: 213 MSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDC 272 Query: 259 LSWLDSQKFATVGADATIRVW-------DVTTSKCVQKWTLDKQQLGNQQVGVVATG--- 308 + WL + + I W D+ K + + Q + Sbjct: 273 VRWL-GDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSM 331 Query: 309 ---NGRIISLSLDGTLNFYELG----HDEVLKTISGHN--KGITALTVNP----LISGSY 355 + + G L ++L H T++ H I + + LI+ Sbjct: 332 DFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCD 391 Query: 356 DGRIMEWS 363 D I W Sbjct: 392 DASIWRWD 399 Score = 61.1 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 33/301 (10%), Positives = 92/301 (30%), Gaps = 31/301 (10%) Query: 125 DFEGRRLCVVGEGRDNFGVFISWDSGNSL------GEVSGHSQRINACHLKQSRPMRSMT 178 EG L G + ++ G + + A + + Sbjct: 66 SKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLA 125 Query: 179 VGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKS 238 V ++ P + + G+ + +++F P +++V D + ++ ++ Sbjct: 126 VAGSRGIIRIINPI--TMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQT 183 Query: 239 GEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLG 298 + + + A L +K + G D ++++W + + + + Sbjct: 184 DTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNP 243 Query: 299 NQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTV--NPLISGSYD 356 N+ + ++F + ++ H + + + ++S S + Sbjct: 244 NKTNRPFIS-----------QKIHFPDFSTRDI------HRNYVDCVRWLGDLILSKSCE 286 Query: 357 GRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANN 416 I+ W M D I + S++ +D + + K+ + N Sbjct: 287 NAIVCWKPGKMEDD----IDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGN 342 Query: 417 D 417 Sbjct: 343 Q 343 >4J0X-A nrPDB Length = 451 Score = 59.9 bits (143), Expect = 3e-09, Method: Composition-based stats. Identities = 36/289 (12%), Positives = 85/289 (29%), Gaps = 23/289 (7%) Query: 245 IEDDQEPVQGGIFALS-WLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVG 303 E+ E I ++ D + T G D + VW + V+ ++ + Sbjct: 106 YENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLA 165 Query: 304 VVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGI---TALTVNPLIS-GSYDGRI 359 + ++ + D + Y + L+ + GH+ + +AL + ++ G+ D Sbjct: 166 FRKNSD-QLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGARDRTA 224 Query: 360 MEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGF 419 M W D + L + + ++ + Sbjct: 225 MLW----KIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSI 280 Query: 420 TAVLTNDDDLLILQSFTGDII-------KSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVF 472 V DD I S G+I K + + ++ + E ++ Sbjct: 281 DVVSMVDDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISGETDEELRKR 340 Query: 473 KLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSRE 521 +L ++ + + P +G G + ++ + Sbjct: 341 QLQGKKLLQPFW------ITSLYAIPYSNVFISGSWSGSLKVWKISDNL 383 Score = 57.2 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 62/347 (17%), Positives = 114/347 (32%), Gaps = 49/347 (14%) Query: 32 AIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVI 91 + Y G + ++ SK GH ++T SP +Y+ +G K+I Sbjct: 88 KLKYAKGGAKYI-----PTSKHEYENTTEGHYDEILTVAA-SP--DGKYVVTGGRDRKLI 139 Query: 92 VWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGN 151 VW + S+ + G + +++ +L S + + Sbjct: 140 VWS------TESLSPVKVIPTKDRRGEVLSLAFRKNSDQLYASCADFKIRT--YSINQFS 191 Query: 152 SLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRD 211 L + GH + + D + + ++ P Q R Sbjct: 192 QLEILYGHHDIVEDIS-ALAMERCVTVGARDRTAMLWKIPDETRLTFRGGDEPQKLLRRW 250 Query: 212 VEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVG 271 ++ + GE D ++ D +S L + E G I +S +D F T Sbjct: 251 MKENAKEGE-------DGEVKYPD-ESEAPLFFCE-------GSIDVVSMVDDFHFITGS 295 Query: 272 ADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEV 331 + I +W + K + +T G++ + IS D L +L ++ Sbjct: 296 DNGNICLWSLAKKKPI--FTERIAH------GILPEPSFNDISGETDEELRKRQLQGKKL 347 Query: 332 LKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQDHSNL 374 L+ IT+L P ISGS+ G + W S + L Sbjct: 348 LQPF-----WITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELL 389 Score = 38.0 bits (86), Expect = 0.012, Method: Composition-based stats. Identities = 23/125 (18%), Positives = 51/125 (40%), Gaps = 13/125 (10%) Query: 490 KPSYISISPSETYIAAGDVMGKILLYDLQS-REVKTSRWAFHTSKINAISWKPAEKGANE 548 + ++ SP Y+ G K++++ +S VK ++ +++++ Sbjct: 116 EILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFR-------- 167 Query: 549 EEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSGA-DACI 607 + + L A+ + D I YS+ + ++ L H D V ++ V+ GA D Sbjct: 168 -KNSDQLYASCA-DFKIRTYSINQFSQLEI-LYGHHDIVEDISALAMERCVTVGARDRTA 224 Query: 608 KRWNV 612 W + Sbjct: 225 MLWKI 229 >4E5Z-B nrPDB Length = 436 Score = 59.9 bits (143), Expect = 3e-09, Method: Composition-based stats. Identities = 51/321 (15%), Positives = 108/321 (33%), Gaps = 41/321 (12%) Query: 68 TTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFE 127 T++ + P S G + G +++W + + ++ G I+ + ++ Sbjct: 123 TSLAWHPTHPSTVAV-GSKGGDIMLWNFGIKDKPTFIKGI------GAGGSITGLKFNPL 175 Query: 128 GRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINA--CHLKQSRPMRSMTVGDDGSV 185 G D ++ V S IN C L S R + GD+ Sbjct: 176 NTNQFYASS---MEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGN 232 Query: 186 VFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKS---GEFL 242 V K + R H K+ + V +P F+ T D+ + +D + Sbjct: 233 VILLNMDGKELWNLRMHKKKVTHV---ALNPCCDWFLATASVDQTVKIWDLRQVRGKASF 289 Query: 243 KYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQL----- 297 Y + PV F+ D + T + IRV+ + C + Sbjct: 290 LYSLPHRHPVNAACFS---PDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLT 346 Query: 298 -----GNQQVGVVAT---GNGRIISLS--LDGTLNFYELGHDEVLKTISG-HNKGITAL- 345 + + ++ + S + T++ ++ +++ + + GI++L Sbjct: 347 PIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLN 406 Query: 346 TVNPL---ISGSYDGRIMEWS 363 NP+ ++ + I+ WS Sbjct: 407 EFNPMGDTLASAMGYHILIWS 427 Score = 59.2 bits (141), Expect = 5e-09, Method: Composition-based stats. Identities = 46/225 (20%), Positives = 79/225 (35%), Gaps = 19/225 (8%) Query: 21 TTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQY 80 T L++ PT + K + + G P ++ G G S+ T +KF+P+ +Q+ Sbjct: 122 ATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSI-TGLKFNPLNTNQF 180 Query: 81 LCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDN 140 S E G + + + + + + D+S R+ V G DN Sbjct: 181 YASSME-GTTRLQDFKGNILRVFASSDTINIWFC----SLDVS---ASSRMVVTG---DN 229 Query: 141 FGVFISWD-SGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASD 199 G I + G L + H +++ L T D +V + + AS Sbjct: 230 VGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASF 289 Query: 200 RTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISC-----FDGKSG 239 V FSPD G ++T +I +D G Sbjct: 290 LYSLPHRHPVNAACFSPD-GARLLTTDQKSEIRVYSASQWDCPLG 333 Score = 37.6 bits (85), Expect = 0.018, Method: Composition-based stats. Identities = 44/253 (17%), Positives = 79/253 (31%), Gaps = 35/253 (13%) Query: 323 FYELGHDEVLKTISGHNKGITALTVNP-----LISGSYDGRIMEWS-------SSSMHQD 370 + L +L+ + ++ T+L +P + GS G IM W+ + Sbjct: 103 LHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIG 162 Query: 371 HSNLIVSLDNSK---AQEYSSISWDDT----LKVNGITKHEFGSQPKVA----SANNDGF 419 I L + Q Y+S T K N + + + Sbjct: 163 AGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSR 222 Query: 420 TAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDL-- 477 V ++ +IL + G + ++R++ L + Q K+ DL Sbjct: 223 MVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQ 282 Query: 478 ---EVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREV------KTSRWA 528 + SF P R + SP + D +I +Y + R Sbjct: 283 VRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHF 342 Query: 529 FHTSKINAISWKP 541 H + I A +W P Sbjct: 343 QHLTPIKA-AWHP 354 >3F3P-A nrPDB Length = 351 Score = 59.9 bits (143), Expect = 3e-09, Method: Composition-based stats. Identities = 59/322 (18%), Positives = 105/322 (32%), Gaps = 28/322 (8%) Query: 26 YDPTTNAIAYPCG-KSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSG 84 YD +A + V LD S + H SS+V SP G + + S Sbjct: 19 YDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYG-RIIASA 77 Query: 85 DESGKVIVWGWTFDKESNSVEV-NVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNF-- 141 V +W D+E S N G + + + L + G D Sbjct: 78 SYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILR 137 Query: 142 -------GVFISWDSGNSLGEVS----GHSQRINACHLKQSR--PMRSMTVGDDGSVVFY 188 SW + + +S H Q SR P + + ++++ Sbjct: 138 LYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQ 197 Query: 189 QGPPFKFSASDRTHHKQGSFVRDVEFSPDSG---EFVITVGSDRKISCFDGKSGEFLKYI 245 +G K + + S +R + ++P G + + T D +I F E L + Sbjct: 198 RGKDGKLHVAAK-LPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKIT--EKLSPL 254 Query: 246 EDDQEPVQGGIFALSWLDSQKFATVGAD-ATIRVWDVTTSKCVQKWTLDKQQLGNQQVGV 304 ++ +F S D A +D T ++ ++ V+ + G V Sbjct: 255 ASEESLTNSNMFDNS-ADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVW-SV 312 Query: 305 VATGNGRII-SLSLDGTLNFYE 325 G I+ S DG + ++ Sbjct: 313 SWNLTGTILSSAGDDGKVRLWK 334 Score = 52.6 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 44/285 (15%), Positives = 96/285 (33%), Gaps = 42/285 (14%) Query: 178 TVGDDGSVVFYQGPPFKFSASDR-THHKQGSFVRDVEF-SPDSGEFVITVGSDRKISCFD 235 T D + ++ + + S + +++ SP+ G + + D+ + ++ Sbjct: 28 TCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWE 87 Query: 236 ---------GKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKC 286 G+ L + D + + FA + L K A +G D +R++D Sbjct: 88 EDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHL-GLKLACLGNDGILRLYDALEPSD 146 Query: 287 VQKWTLDK---------QQLGNQQVGVVATG---NGRIISLSLDGTLNFYELGHDEVLK- 333 ++ WTL + + +++S Y+ G D L Sbjct: 147 LRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHV 206 Query: 334 --TISGHNKGITALTVNP--------LISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKA 383 + GH I +++ P + +G DGRI + + + S ++ Sbjct: 207 AAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLS----PLASEESLTN 262 Query: 384 QEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDD 428 S D + G + + + A ++ +L+ DD Sbjct: 263 SNMFDNSADVDMDAQGRSD---SNTEEKAELQSNLQVELLSEHDD 304 Score = 34.5 bits (77), Expect = 0.13, Method: Composition-based stats. Identities = 22/128 (17%), Positives = 43/128 (33%), Gaps = 22/128 (17%) Query: 500 ETYIAAGDVMGKILLYDLQSREVK---TSRWAFHTSKINAISWKPAEKGANEEEIEEDLV 556 ++A I ++ L + W H S I AI W E G ++ Sbjct: 23 GRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGR--------II 74 Query: 557 ATGSLDTNIFIYSVK--------RPMKIIKALNAHKDGVNNLLWETPS---TLVSSGADA 605 A+ S D + ++ R + LN K + ++ + L G D Sbjct: 75 ASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDG 134 Query: 606 CIKRWNVV 613 ++ ++ + Sbjct: 135 ILRLYDAL 142 Score = 30.3 bits (66), Expect = 2.7, Method: Composition-based stats. Identities = 12/56 (21%), Positives = 18/56 (32%) Query: 56 VVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSE 111 V + H S L S + GKV +W T+ E + V + Sbjct: 296 VELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITAQQ 351 >5WLC-SG nrPDB Length = 573 Score = 59.6 bits (142), Expect = 4e-09, Method: Composition-based stats. Identities = 36/289 (12%), Positives = 85/289 (29%), Gaps = 23/289 (7%) Query: 245 IEDDQEPVQGGIFALS-WLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVG 303 E+ E I ++ D + T G D + VW + V+ ++ + Sbjct: 228 YENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLA 287 Query: 304 VVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGI---TALTVNPLIS-GSYDGRI 359 + ++ + D + Y + L+ + GH+ + +AL + ++ G+ D Sbjct: 288 FRKNSD-QLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGARDRTA 346 Query: 360 MEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGF 419 M W D + L + + ++ + Sbjct: 347 MLW----KIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSI 402 Query: 420 TAVLTNDDDLLILQSFTGDII-------KSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVF 472 V DD I S G+I K + + ++ + E ++ Sbjct: 403 DVVSMVDDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISGETDEELRKR 462 Query: 473 KLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSRE 521 +L ++ + + P +G G + ++ + Sbjct: 463 QLQGKKLLQPFW------ITSLYAIPYSNVFISGSWSGSLKVWKISDNL 505 Score = 56.5 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 62/347 (17%), Positives = 114/347 (32%), Gaps = 49/347 (14%) Query: 32 AIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVI 91 + Y G + ++ SK GH ++T SP +Y+ +G K+I Sbjct: 210 KLKYAKGGAKYI-----PTSKHEYENTTEGHYDEILTVAA-SP--DGKYVVTGGRDRKLI 261 Query: 92 VWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGN 151 VW + S+ + G + +++ +L S + + Sbjct: 262 VWS------TESLSPVKVIPTKDRRGEVLSLAFRKNSDQLYASCADFKIRT--YSINQFS 313 Query: 152 SLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRD 211 L + GH + + D + + ++ P Q R Sbjct: 314 QLEILYGHHDIVEDIS-ALAMERCVTVGARDRTAMLWKIPDETRLTFRGGDEPQKLLRRW 372 Query: 212 VEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVG 271 ++ + GE D ++ D +S L + E G I +S +D F T Sbjct: 373 MKENAKEGE-------DGEVKYPD-ESEAPLFFCE-------GSIDVVSMVDDFHFITGS 417 Query: 272 ADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEV 331 + I +W + K + +T G++ + IS D L +L ++ Sbjct: 418 DNGNICLWSLAKKKPI--FTERIAH------GILPEPSFNDISGETDEELRKRQLQGKKL 469 Query: 332 LKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQDHSNL 374 L+ IT+L P ISGS+ G + W S + L Sbjct: 470 LQPF-----WITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELL 511 Score = 37.6 bits (85), Expect = 0.015, Method: Composition-based stats. Identities = 23/125 (18%), Positives = 51/125 (40%), Gaps = 13/125 (10%) Query: 490 KPSYISISPSETYIAAGDVMGKILLYDLQS-REVKTSRWAFHTSKINAISWKPAEKGANE 548 + ++ SP Y+ G K++++ +S VK ++ +++++ Sbjct: 238 EILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFR-------- 289 Query: 549 EEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSGA-DACI 607 + + L A+ + D I YS+ + ++ L H D V ++ V+ GA D Sbjct: 290 -KNSDQLYASCA-DFKIRTYSINQFSQLEI-LYGHHDIVEDISALAMERCVTVGARDRTA 346 Query: 608 KRWNV 612 W + Sbjct: 347 MLWKI 351 >5YZG-2 nrPDB Length = 646 Score = 58.4 bits (139), Expect = 9e-09, Method: Composition-based stats. Identities = 56/438 (12%), Positives = 135/438 (30%), Gaps = 84/438 (19%) Query: 75 IKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVV 134 + ++ + G V W + + F+ G I I+ EG C V Sbjct: 98 CTKTDFIITASHDGHVKFWKKIEEG------IEFVKHFRSHLGVIESIAVSSEGALFCSV 151 Query: 135 GEGRD-NFGVFISWDSGN--SLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGP 191 G+ + +++D N LG G + I + S+ + + + Sbjct: 152 GDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYC----PGDAISSVAASEKSTGKIFIYD 207 Query: 192 PFKFSASDRTHHK-QGSFVRDVEFSPDSGEFVITVGSDRKISC----------------- 233 + K S + + +P + V SD+ Sbjct: 208 GRGDNQPLHIFDKLHTSPLTQIRLNP---VYKAVVSSDKSGMIEYWTGPPHEYKFPKNVN 264 Query: 234 FDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKW--- 290 ++ K+ L + F+ D +K AT+G+D +R++ T K ++ + Sbjct: 265 WEYKTDTDLYEFAKCKAYPTSVCFS---PDGKKIATIGSDRKVRIFRFVTGKLMRVFDES 321 Query: 291 ---------------TLDKQQLGNQQVGVVATGNGRIISLSLDGT-----------LNFY 324 ++ + + + R+I++ D T + Sbjct: 322 LSMFTELQQMRQQLPDMEFGRRMAVERELEKVDAVRLINIVFDETGHFVLYGTMLGIKVI 381 Query: 325 ELGHDEVLKTISGHNKGITALTVNPLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQ 384 + + ++ + G + I + + + G + +++ + + S+ Sbjct: 382 NVETNRCVRIL-GKQENIRVMQL-----ALFQGIAKKHRAATTIE--------MKASENP 427 Query: 385 EYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVR 444 +I D T+ K+ F K T +D D+ + +++ + + Sbjct: 428 VLQNIQADPTIVCTSFKKNRFYMFTKR----EPEDTKSADSDRDVFNEKPSKEEVMAATQ 483 Query: 445 LNSPGSAVSLSQNYVAVG 462 P + + ++G Sbjct: 484 AEGPKRVSDSAIIHTSMG 501 Score = 48.4 bits (113), Expect = 9e-06, Method: Composition-based stats. Identities = 35/213 (16%), Positives = 75/213 (35%), Gaps = 40/213 (18%) Query: 342 ITALTVNPLISGSYDGRIMEW-------SSSSMHQDHSNLIVSLD-NSKAQEYSSISWDD 393 + + +I+ S+DG + W + H +I S+ +S+ + S+ D Sbjct: 96 VVCTKTDFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSSEGALFCSVGDDK 155 Query: 394 TLKVNGITKHE---------FGSQPKVASANNDGFTAVLTNDDD---LLILQSFTGDIIK 441 +KV + + F Q + D ++V ++ + I + Sbjct: 156 AMKVFDVVNFDMINMLKLGYFPGQCEWIYCPGDAISSVAASEKSTGKIFIYDGRGDNQPL 215 Query: 442 SV---RLNSPGSAVSLSQNYVAVGLEEGNTI--------QVFKLSDLEVSFDLKT----- 485 + SP + + L+ Y AV + + + +K V+++ KT Sbjct: 216 HIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFPK-NVNWEYKTDTDLY 274 Query: 486 ---PLRAKPSYISISPSETYIAAGDVMGKILLY 515 +A P+ + SP IA K+ ++ Sbjct: 275 EFAKCKAYPTSVCFSPDGKKIATIGSDRKVRIF 307 >5K19-A nrPDB Length = 569 Score = 58.0 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 23/178 (12%), Positives = 53/178 (29%), Gaps = 28/178 (15%) Query: 205 QGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKS--GEFLKYIEDDQEPVQGGIFAL--- 259 S V V++ P S + S + ++ + G + + ++ + Sbjct: 148 DKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSK 207 Query: 260 --------------------SWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGN 299 D + A V D +RV++ + V+ K G Sbjct: 208 STRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDS---VELHGTMKSYFGG 264 Query: 300 QQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPLISGSYDG 357 + I++ D + + V+ GH ++ + +P + +G Sbjct: 265 LLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEG 322 Score = 57.2 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 27/184 (14%), Positives = 63/184 (34%), Gaps = 15/184 (8%) Query: 419 FTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLE 478 + + L ++ +G++ N + + + +Y + E + K Sbjct: 154 CVKWVPGSESLFLVAHSSGNMYL---YNVEHTCGTTAPHYQLLKQGESFAVHTCKSKSTR 210 Query: 479 VSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAIS 538 T + + SP ++A G + +++ S E+ + + + Sbjct: 211 NPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELH-GTMKSYFGGLLCVC 269 Query: 539 WKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTL 598 W P K + TG D + ++S I + + HK V+ + ++ +T Sbjct: 270 WSPDGKY----------IVTGGEDDLVTVWSFVDCRVIARG-HGHKSWVSVVAFDPYTTS 318 Query: 599 VSSG 602 V G Sbjct: 319 VEEG 322 Score = 52.2 bits (123), Expect = 7e-07, Method: Composition-based stats. Identities = 37/245 (15%), Positives = 77/245 (31%), Gaps = 40/245 (16%) Query: 33 IAYPCGKSA-FVRCLDDGDS----------KVPPVVQFTGHGSSVVTTVKFSPIKGSQYL 81 + + CG +A + L G+S P++++T + FSP ++L Sbjct: 179 VEHTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEG-ALNEFAFSP--DGKFL 235 Query: 82 CSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNF 141 + G + V+ + V + + G + + W +G+ + GE D+ Sbjct: 236 ACVSQDGFLRVFNFD--------SVELHGTMKSYFGGLLCVCWSPDGKYIVTGGE--DDL 285 Query: 142 GVFISWDSGNSLGEVSGHSQRINACHLKQ-------SRPMRSMTVGDDGSVVFYQGPPFK 194 S+ + GH ++ PM +D + + G Sbjct: 286 VTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRA 345 Query: 195 FSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSG-----EFLKYIEDDQ 249 S R + + R V + +VG D ++ +D + L Sbjct: 346 NSTQSRLSKRNSTDSRPVSVT----YRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHT 401 Query: 250 EPVQG 254 + Sbjct: 402 NVMNA 406 Score = 50.3 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 27/203 (13%), Positives = 62/203 (30%), Gaps = 17/203 (8%) Query: 153 LGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDV 212 L G +N + V DG + + + + +++ + V Sbjct: 214 LKWTVGE-GALNEFAFSPDGKFLAC-VSQDGFLRVFNFDSVELHGTMKSYFGG---LLCV 268 Query: 213 EFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKF----A 268 +SPD G++++T G D ++ + + + V F ++ Sbjct: 269 CWSPD-GKYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEF 327 Query: 269 TVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGH 328 + + + + + T + N + R S+ D L ++L Sbjct: 328 SGSDEDFQDL--LHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTE 385 Query: 329 D-----EVLKTISGHNKGITALT 346 D + L H + A + Sbjct: 386 DILFPHQPLSRARTHTNVMNATS 408 >2P9P-C nrPDB Length = 372 Score = 56.5 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 36/259 (13%), Positives = 88/259 (33%), Gaps = 24/259 (9%) Query: 118 PISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSM 177 PIS +W+ + ++ + + S + + E+ H+ ++ R + Sbjct: 10 PISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSN-RIV 68 Query: 178 TVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGK 237 T G D + + + + R V ++P+ +F + R IS + Sbjct: 69 TCGTDRNAYVWTL-KGRTWKPTLVILRINRAARCVRWAPNEKKFAV-GSGSRVISICYFE 126 Query: 238 SGEFLKYIEDDQEPVQGGIFALSWLDSQK-FATVGADATIRVWDVTTSKCVQK------- 289 + ++P++ + +L W + A D R++ + ++ Sbjct: 127 QENDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWG 186 Query: 290 ---------WTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNK 340 + V A G+ R+ +S D T+ + + T++ Sbjct: 187 SKMPFGELMFESSSSCGWVHGVCFSANGS-RVAWVSHDSTVCLADADKKMAVATLASETL 245 Query: 341 GITALTV---NPLISGSYD 356 + A+T + L++ +D Sbjct: 246 PLLAVTFITESSLVAAGHD 264 Score = 32.2 bits (71), Expect = 0.60, Method: Composition-based stats. Identities = 43/362 (11%), Positives = 93/362 (25%), Gaps = 52/362 (14%) Query: 37 CGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWT 96 C + V + +K V + H V S + + VW Sbjct: 26 CPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGV---DWAPDSNRIVTCGTDRNAYVWTLK 82 Query: 97 FDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEV 156 ++ + + W ++ V R ++ N Sbjct: 83 GRTWKPTL------VILRINRAARCVRWAPNEKKFAVGSGSR--VISICYFEQENDWWVC 134 Query: 157 SGHSQRINACHLKQS-RPMRSMTVGD--DGSVVFYQ---------------GPPFKFSAS 198 + I + L P + D + G F Sbjct: 135 KHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGEL 194 Query: 199 DRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFA 258 +V V FS + G V V D + D + + + P+ A Sbjct: 195 MFESSSSCGWVHGVCFSAN-GSRVAWVSHDSTVCLADADKKMAVATLASETLPL----LA 249 Query: 259 LSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQ-QLGNQQVGVVATGNGRII--SL 315 ++++ G D ++ ++ + + Q G+ A + + Sbjct: 250 VTFITESSLVAAGHDCFPVLFTYDSAAGKLSFGGRLDVPKQSSQRGLTARERFQNLDKKA 309 Query: 316 SLDGTLNFYELGHDEVLKTISGHNKGITALT--------VNPLISGSYDGRIMEWSSSSM 367 S +G+ L ++ H ++ ++ + + DG + W S+ Sbjct: 310 SSEGSA-----AAGAGLDSL--HKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVRSL 362 Query: 368 HQ 369 Sbjct: 363 ES 364 >4PSX-B nrPDB Length = 401 Score = 56.5 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 44/274 (16%), Positives = 80/274 (29%), Gaps = 40/274 (14%) Query: 52 KVPPVVQFTGHGSSVV--------TTVKFSPIKG---------SQYLCSGDESGKVIVWG 94 V G G++ + +T+KF G L SG + V +W Sbjct: 130 DPNIVATINGQGTTFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWE 189 Query: 95 WTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLG 154 + V++ + + I+D W + L + + ++ Sbjct: 190 VGSGGDP---TKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTID 246 Query: 155 EVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEF 214 V Q N G D V Y K + V ++EF Sbjct: 247 TVKC-PQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMS--GHEDAVNNLEF 303 Query: 215 SPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQK-------- 266 S V++ GSD ++ +D K + +D ++ V I + S Sbjct: 304 STHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQ 363 Query: 267 ----FATVGADATIRVWDVTTSKCVQKWTLDKQQ 296 A+ + ++VW KC + Sbjct: 364 IPWLVASAEEENILQVW-----KCSHSLPIVGGP 392 Score = 46.5 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 31/206 (15%), Positives = 82/206 (39%), Gaps = 16/206 (7%) Query: 415 NNDGFTAVLTNDDDLLILQSFTGDIIKSVRL---NSPGSAVSLSQNYVAVGLEEGNTIQV 471 D N L S + + +++ N + S + + +T+ + Sbjct: 128 PQDPNIVATINGQGTTFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVAL 187 Query: 472 FKL-SDLEVSFDL--KTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWA 528 +++ S + + + L + I+ ++ + D+ G + + +K + Sbjct: 188 WEVGSGGDPTKPVRTWNDLHSDI----INDNKWHNFNKDLFGTV----SEDSLLKINDVR 239 Query: 529 FHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVN 588 + + I+ + +L+A +D+ +++Y ++ + + ++ H+D VN Sbjct: 240 ANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVN 299 Query: 589 NLLWET--PSTLVSSGADACIKRWNV 612 NL + T +VSSG+D + W++ Sbjct: 300 NLEFSTHVDGVVVSSGSDNRLMMWDL 325 Score = 39.1 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 43/306 (14%), Positives = 93/306 (30%), Gaps = 82/306 (26%) Query: 291 TLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPL 350 TL + + GR++S S D T+ +E+G Sbjct: 155 TLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSG--------------------- 193 Query: 351 ISGSYDGRIMEWSSSSMHQDHSNLIVSLD--NSKAQEYSSISWDDTLKVNGITKHEFGSQ 408 G + W+ HS++I N + ++S D LK+N + + Sbjct: 194 --GDPTKPVRTWNDL-----HSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRAN----- 241 Query: 409 PKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNT 468 N T + L + +++ + ++S L + G+ Sbjct: 242 ------NTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHE 295 Query: 469 IQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVK----- 523 V ++LE S +++ +++G +++++DL+ + Sbjct: 296 DAV---NNLEFS-----------THV----DGVVVSSGS-DNRLMMWDLKQIGAEQTPDD 336 Query: 524 --------TSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMK 575 A H S +N P LVA+ + + ++ + Sbjct: 337 AEDGVPELIMVHAGHRSSVNDFDLNPQIPW---------LVASAEEENILQVWKCSHSLP 387 Query: 576 IIKALN 581 I+ Sbjct: 388 IVGGPP 393 >5CXB-B nrPDB Length = 369 Score = 56.1 bits (133), Expect = 5e-08, Method: Composition-based stats. Identities = 62/380 (16%), Positives = 112/380 (29%), Gaps = 83/380 (21%) Query: 50 DSKVPPVVQ---FTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEV 106 + K P VQ F GH V +V P L +G + G V VW ++ SV++ Sbjct: 5 ELKPFPTVQQTIFRGHEGRVR-SVAIDPT--GVALATGGDDGTVRVWELLTGRQVWSVKL 61 Query: 107 NVKSEFQVLAGPISDISW-DFEGRRLCVVGEGRDNF-------GVFISWDSGNSLGEVSG 158 N ++ + W + + G D F V + D + +G Sbjct: 62 NGDE-------AVNTVRWRPTKDTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAG 114 Query: 159 HSQRIN--------------------ACHLKQSRPMRSMTVGDDGSVVFY---------- 188 N L+ + +TV + + Sbjct: 115 FGHATNGKQQANLPPGKEPPGKWARPGTRLEDEGVLLRITVRSTIKAISWHRRGDHFATV 174 Query: 189 QGPPFKFSASDRTHHKQGSFV---------RDVEFSPDSGEFVITVGSDRKISCFDGKSG 239 + S + T K + + + F P F + R I C+D + Sbjct: 175 SPSGQRSSVAIHTLSKHLTQIPFRKLNGLAQTASFHPLRPLFFVATQ--RSIRCYDLQKL 232 Query: 240 EFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGN 299 E +K ++ + + F + D + +W T+ Sbjct: 233 ELVKIVQPGAKWISS--FDV-HPGGDNLVVGSYDKRL-LWHDLDLSNRPYKTMRFHTEAI 288 Query: 300 QQVGVVATGNGRIISLSLDGTLNFY-------ELGHDEV--LKTISGHNK----GITALT 346 + V G S DG+L + +L + + +K + GH G+ + Sbjct: 289 RAVRFHKGGLPLFADASDDGSLQIFHGKVPNDQLENPTIVPVKMLKGHKVVNKLGVLDID 348 Query: 347 VNP----LISGSYDGRIMEW 362 +P +S DG W Sbjct: 349 WHPREPWCVSAGADGTARLW 368 Score = 53.0 bits (125), Expect = 4e-07, Method: Composition-based stats. Identities = 63/374 (16%), Positives = 118/374 (31%), Gaps = 67/374 (17%) Query: 287 VQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVL--KTISGHNKGITA 344 VQ+ + + V + TG + + DGT+ +EL + ++G ++ + Sbjct: 12 VQQTIFRGHEGRVRSVAIDPTGVA-LATGGDDGTVRVWELLTGRQVWSVKLNG-DEAVNT 69 Query: 345 LTVNP----LISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGI 400 + P I + G M H ++ +LD + ++ + + Sbjct: 70 VRWRPTKDTFILAAAAGE----DIFLMIPTHPSVTPALDQAS-RDILNAGFGHATNGKQQ 124 Query: 401 TKHEFGSQPKV-ASAN------NDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVS 453 G +P + + I GD +V + S+V+ Sbjct: 125 ANLPPGKEPPGKWARPGTRLEDEGVLLRITVRSTIKAISWHRRGDHFATVSPSGQRSSVA 184 Query: 454 LSQ-----NYVAVGLEEG-------------------NTIQVFKLSDLEVSFDLKTPLRA 489 + + G +I+ + L LE+ ++ P Sbjct: 185 IHTLSKHLTQIPFRKLNGLAQTASFHPLRPLFFVATQRSIRCYDLQKLELVKIVQ-PGAK 243 Query: 490 KPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEE 549 S + P + G ++L +DL FHT I A+ + Sbjct: 244 WISSFDVHPGGDNLVVGSYDKRLLWHDLDLSNRPYKTMRFHTEAIRAVRF---------H 294 Query: 550 EIEEDLVATGSLDTNIFIYSVKRPMKI--------IKALNAHKD----GVNNLLWE-TPS 596 + L A S D ++ I+ K P +K L HK GV ++ W Sbjct: 295 KGGLPLFADASDDGSLQIFHGKVPNDQLENPTIVPVKMLKGHKVVNKLGVLDIDWHPREP 354 Query: 597 TLVSSGADACIKRW 610 VS+GAD + W Sbjct: 355 WCVSAGADGTARLW 368 >5A9Q-7 nrPDB Length = 360 Score = 55.3 bits (131), Expect = 7e-08, Method: Composition-based stats. Identities = 27/161 (16%), Positives = 54/161 (33%), Gaps = 15/161 (9%) Query: 159 HSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFS-PD 217 H I+ R T D SV + + V V ++ P+ Sbjct: 11 HKDLIHDVSFDFHG-RRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPE 69 Query: 218 SGEFVITVGSDRKISCFD---GKSGEFLK---------YIEDDQEPVQGGIFALSWLDSQ 265 G+ + + DR + ++ G+S + L+ + D + V FA Sbjct: 70 FGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPK-HMGL 128 Query: 266 KFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVA 306 AT AD +R+++ + +W+L + ++ Sbjct: 129 MLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCIS 169 Score = 48.4 bits (113), Expect = 8e-06, Method: Composition-based stats. Identities = 34/177 (19%), Positives = 60/177 (33%), Gaps = 23/177 (12%) Query: 205 QGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLD- 263 + DV F G + T SD+ + +D KS + + G ++ ++W Sbjct: 11 HKDLIHDVSFDFH-GRRMATCSSDQSVKVWD-KSESGDWHCTASWKTHSGSVWRVTWAHP 68 Query: 264 --SQKFATVGADATIRVWDVTTSKC----------VQKWTLDKQQLGNQQVGVVATGNG- 310 Q A+ D T VW+ + V++ TL + V G Sbjct: 69 EFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGL 128 Query: 311 RIISLSLDGTLNFY------ELGHDEVLKTISGHNKGITALTVNPLISGSYDGRIME 361 + + S DG + Y L + IS + ++ NP S ++ I Sbjct: 129 MLATCSADGIVRIYEAPDVMNLSQWSLQHEISC-KLSCSCISWNPSSSRAHSPMIAV 184 Score = 46.1 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 43/316 (13%), Positives = 92/316 (29%), Gaps = 62/316 (19%) Query: 78 SQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFE--GRRLCVVG 135 + + + V VW + + + + ++ +G + ++W G+ L Sbjct: 24 GRRMATCSSDQSVKVWDKSESGDWH-----CTASWKTHSGSVWRVTWAHPEFGQVLASCS 78 Query: 136 EGRDNFGVFISWDS--GNSLGEVSGHSQRINACHLKQSRP-------------MRSMTVG 180 R W+ G S ++ G S + L SR + T Sbjct: 79 FDR----TAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCS 134 Query: 181 DDGSVVFYQGPPFKFSASDRTHHKQGSFV--RDVEFSPDS----GEFVITVGSDRK---- 230 DG V Y+ P + H+ + + ++P S + D Sbjct: 135 ADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAM 194 Query: 231 ISCFDGKSGEFLK------YIEDDQEPVQGGIFALSWLDS-QKFATVGADATIRVWDVTT 283 + E + + +PV FA + S A D +R++ + Sbjct: 195 AKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKD--VRIFTLKP 252 Query: 284 SKCVQKWTL-------------DKQQLGNQQVGVVATGNGRIISLSLDGTLNFYE---LG 327 + + D +V TG + S DG + ++ + Sbjct: 253 VRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITG-TVLASSGDDGCVRLWKANYMD 311 Query: 328 HDEVLKTISGHNKGIT 343 + + + G+ + Sbjct: 312 NWKCTGILKGNGSPVN 327 Score = 42.6 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 47/336 (13%), Positives = 104/336 (30%), Gaps = 59/336 (17%) Query: 293 DKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHD---EVLKTISGHNKGITALT-VN 348 K + + R+ + S D ++ ++ + H+ + +T + Sbjct: 11 HKDLIHDVSFDFH---GRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAH 67 Query: 349 P-----LISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKH 403 P L S S+D W + ++ + D+ K Sbjct: 68 PEFGQVLASCSFDRTAAVWEEIVGESNDK------LRGQSHWVKRTTLVDSRTSVTDVKF 121 Query: 404 EFGSQPKVASA-NNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNY---- 458 + + + DG + D ++ + + S +S + + Sbjct: 122 APKHMGLMLATCSADGIVRIYEAPD---VMNLSQWSLQHEISCKLSCSCISWNPSSSRAH 178 Query: 459 ---VAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLY 515 +AVG ++ + + K+ E + + + +A+ T + D + I Sbjct: 179 SPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAE----------TLMTVTDPVHDIAFA 228 Query: 516 DLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMK 575 R +FH I + + + ++L ++G K + Sbjct: 229 PNLGR-------SFHILAIA----TKDVRIFTLKPVRKELTSSGG--------PTKFEIH 269 Query: 576 IIKALNAHKDGVNNLLWETPST-LVSSGADACIKRW 610 I+ + H V + W T L SSG D C++ W Sbjct: 270 IVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLW 305 Score = 38.0 bits (86), Expect = 0.013, Method: Composition-based stats. Identities = 46/259 (17%), Positives = 79/259 (30%), Gaps = 52/259 (20%) Query: 67 VTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDF 126 VT VKF+P L + G V ++ E+ V + Q + Sbjct: 116 VTDVKFAPKHMGLMLATCSADGIVRIY------EAPDVMNLSQWSLQ----------HEI 159 Query: 127 EGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVV 186 + C ISW+ +S + A S P V + Sbjct: 160 SCKLSCSC----------ISWNPSSSRA-----HSPMIAVGSDDSSPNAMAKVQ-----I 199 Query: 187 FYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSG-EFVITVGSDRKISCFDGK-------- 237 F + A T V D+ F+P+ G F I + + + F K Sbjct: 200 FEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTS 259 Query: 238 SGEFLK---YIEDDQEPVQGGIFALSW-LDSQKFATVGADATIRVWD---VTTSKCVQKW 290 SG K +I + ++ +SW + A+ G D +R+W + KC Sbjct: 260 SGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGIL 319 Query: 291 TLDKQQLGNQQVGVVATGN 309 + + + + Sbjct: 320 KGNGSPVNGSSQQGTSNPS 338 >5N4A-A nrPDB Length = 771 Score = 54.9 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 38/260 (14%), Positives = 78/260 (30%), Gaps = 22/260 (8%) Query: 242 LKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDV-----TTSKCVQKWTLDKQQ 296 LK + A+ W + T D TI W++ + + D Sbjct: 3 LKVKQSSANVHSELTAAVGWNVWNELFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHW 62 Query: 297 LGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVN----PLIS 352 A G DG++ V K+I GH +L + L + Sbjct: 63 YPVSSKKTQAGGTDVFAVACTDGSVKILS-RTGRVEKSIEGHKGACISLRWSYDGTALAT 121 Query: 353 GSYDGRIMEWSSS----SMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQ 408 DG + WS + S + + S+ + + + + ++ + + Sbjct: 122 AGEDGSVKIWSRNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGSNVVIKSLSSNAKQNA 181 Query: 409 PKVAS--------ANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVA 460 K + + D + SF + +S + P ++V+ + + Sbjct: 182 WKAHDGVVLKVDWSPINHLIITGGEDCKYKVWDSFGRLLFQSGLFDYPVTSVAWAPSGEL 241 Query: 461 VGLEEGNTIQVFKLSDLEVS 480 + NT+Q+ S Sbjct: 242 FAVGGFNTLQLCDRMGWAYS 261 Score = 54.5 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 32/236 (13%), Positives = 74/236 (31%), Gaps = 21/236 (8%) Query: 174 MRSMTVGDDGSVVFYQ--GPPFKFSASDRTHHKQGS--FVRDVEFSPDSGEFVITVGSDR 229 T DD ++ + G P + ++ + V + + +D Sbjct: 26 NELFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPVSSKKTQAGGTDVFAVACTDG 85 Query: 230 KISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQK 289 + ++G K IE + ++ D AT G D ++++W Sbjct: 86 SVKILS-RTGRVEKSIEGHKGACISLRWS---YDGTALATAGEDGSVKIWS-RNG----M 136 Query: 290 WTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP 349 Q + +V + + + L + H+ + + +P Sbjct: 137 LRSTLAQADSPVYSIVWAYDCDQLCYCTGSNVVIKSLSSNAKQNAWKAHDGVVLKVDWSP 196 Query: 350 ----LISGSYDGRIMEWSSSSMHQDHSN----LIVSLDNSKAQEYSSISWDDTLKV 397 +I+G D + W S S + S+ + + E ++ +TL++ Sbjct: 197 INHLIITGGEDCKYKVWDSFGRLLFQSGLFDYPVTSVAWAPSGELFAVGGFNTLQL 252 Score = 51.1 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 36/186 (19%), Positives = 60/186 (32%), Gaps = 18/186 (9%) Query: 97 FDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWD-SGNSLGE 155 + S V+ + G + W ++G L GE G W +G Sbjct: 85 GSVKILSRTGRVEKSIEGHKGACISLRWSYDGTALATAGED----GSVKIWSRNGMLRST 140 Query: 156 VSGHSQRINACHLKQSRPMRS-MTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEF 214 ++ + + T + VV + + H V V++ Sbjct: 141 LAQADSPVYSIVWAYDCDQLCYCTGSN---VVIKSLSSNAKQNAWKAHDG---VVLKVDW 194 Query: 215 SPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADA 274 SP + +IT G D K +D G L PV +A S + FA G Sbjct: 195 SPINH-LIITGGEDCKYKVWD-SFGRLLFQSGLFDYPVTSVAWAPS---GELFAVGGF-N 248 Query: 275 TIRVWD 280 T+++ D Sbjct: 249 TLQLCD 254 Score = 49.9 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 49/260 (18%), Positives = 77/260 (29%), Gaps = 32/260 (12%) Query: 15 STQRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVV-----QFTGHGSSVVTT 69 ST + T + + P ++ G F DG K+ GH + ++ Sbjct: 51 STLDAYFTDMHWYPVSSKKTQAGGTDVFAVACTDGSVKILSRTGRVEKSIEGHKGACIS- 109 Query: 70 VKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGR 129 L + E G V +W S ++S P+ I W ++ Sbjct: 110 --LRWSYDGTALATAGEDGSVKIW---------SRNGMLRSTLAQADSPVYSIVWAYDCD 158 Query: 130 RLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQ 189 +LC + V S S H + +T G+D + Sbjct: 159 QLCYCTG---SNVVIKSLSSNAKQNAWKAHDGVVLKVDWSP-INHLIITGGEDCKYKVWD 214 Query: 190 GPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQ 249 F V V ++P SGE G + D + K +D Sbjct: 215 ----SFGRLLFQSGLFDYPVTSVAWAP-SGELFAVGGF-NTLQLCDRMGWAYSKIHLNDT 268 Query: 250 EPVQGGIFALSW-LDSQKFA 268 G I LSW DS + A Sbjct: 269 ----GSIMTLSWTADSTQLA 284 Score = 40.7 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 20/127 (15%), Positives = 47/127 (37%), Gaps = 8/127 (6%) Query: 487 LRAKPSYISISPSETYIAAGDVMGKILLYDLQSR-EVKTSRWAFHTSKINAISWKPAEKG 545 + ++ + + I +++ E K S + + ++ W P Sbjct: 12 VHSELTAAVGWNVWNELFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMH---WYPVSSK 68 Query: 546 ANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPST-LVSSGAD 604 + + + D ++ I + R ++ K++ HK +L W T L ++G D Sbjct: 69 KTQAGGTDVFAVACT-DGSVKI--LSRTGRVEKSIEGHKGACISLRWSYDGTALATAGED 125 Query: 605 ACIKRWN 611 +K W+ Sbjct: 126 GSVKIWS 132 Score = 38.8 bits (88), Expect = 0.008, Method: Composition-based stats. Identities = 41/258 (15%), Positives = 71/258 (27%), Gaps = 39/258 (15%) Query: 348 NPLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGS 407 N L + S D I +W+ + + + Y S K + G Sbjct: 26 NELFTCSDDQTIHKWNML-GEPEQKVSTLDAYFTDMHWYPVSS----------KKTQAGG 74 Query: 408 QPKVASANNDGFTAVL--TNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEE 465 A A DG +L T + I I + A + V + Sbjct: 75 TDVFAVACTDGSVKILSRTGRVEKSIEGHKGACISLRWSYDGTALATAGEDGSVKIWSRN 134 Query: 466 GNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTS 525 G +D V + + Y + S +++ L S K + Sbjct: 135 GMLRSTLAQADSPVYSIVWAYDCDQLCYCTGSN-------------VVIKSLSS-NAKQN 180 Query: 526 RWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKD 585 W H + + W P L+ TG D ++ + L + Sbjct: 181 AWKAHDGVVLKVDWSPI----------NHLIITGGEDCKYKVWDSFGRLLFQSGLFDY-- 228 Query: 586 GVNNLLWETPSTLVSSGA 603 V ++ W L + G Sbjct: 229 PVTSVAWAPSGELFAVGG 246 >6BX3-B nrPDB Length = 412 Score = 52.6 bits (124), Expect = 5e-07, Method: Composition-based stats. Identities = 28/133 (21%), Positives = 55/133 (41%), Gaps = 16/133 (12%) Query: 471 VFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSRE---VKTSRW 527 V K +++ ++ PLR + + SP Y+A G G +++YD+ + V + Sbjct: 10 VLKEHPEKLTHTIENPLRTE--CLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNML 67 Query: 528 AFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGV 587 H I +I+W P + L+ T S D +I ++ + +P K +K + + Sbjct: 68 GAHVRPITSIAWSPDGR----------LLLTSSRDWSIKLWDLSKPSKPLKEIR-FDSPI 116 Query: 588 NNLLWETPSTLVS 600 W + Sbjct: 117 WGCQWLDAKRRLC 129 Score = 48.0 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 48/346 (13%), Positives = 105/346 (30%), Gaps = 45/346 (13%) Query: 55 PVVQFTGHGSSVVTTV---------KFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVE 105 P H + T+ +FSP YL G +G +++ +D ++ Sbjct: 7 PFAVLKEHPEKLTHTIENPLRTECLQFSPC--GDYLALGCANGALVI----YDMDTFRPI 60 Query: 106 VNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSG--HSQRI 163 + PI+ I+W +GR L WD + I Sbjct: 61 CVPGNMLGAHVRPITSIAWSPDGRLLLTSSRD----WSIKLWDLSKPSKPLKEIRFDSPI 116 Query: 164 NACHLKQSRPMRSMTV---GDDGSVVFYQGPPFKFSASDRTHHKQGS-----FVRDVEFS 215 C ++ + D V+ + P S + S +V Sbjct: 117 WGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVH 176 Query: 216 PDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADAT 275 +I S + + S + I + + + ++ A +D T Sbjct: 177 TKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRT 236 Query: 276 IRVWDVT--TSKCVQKWTLDKQQLGN-----QQVGVVATGNGRIISLSLDGT----LNFY 324 IR ++++ + TL+ + + + + S G+ L + Sbjct: 237 IRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIW 296 Query: 325 ELGHDEVLKTISGHNKGITAL-----TVNPLISGSYDGRIMEWSSS 365 E +++ + G + + + +++ + +G G + WS Sbjct: 297 ETTSGTLVRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVV 342 Score = 44.9 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 38/214 (17%), Positives = 79/214 (36%), Gaps = 31/214 (14%) Query: 210 RDVEFSPDSGEFVITVGSDRKISCFDGKSGEFL----KYIEDDQEPVQGGIFALSWLDSQ 265 ++FSP G+++ ++ + +D + + + P+ ++ D + Sbjct: 29 ECLQFSP-CGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWS---PDGR 84 Query: 266 KFATVGADATIRVWDVTT-SKCVQKWTLDKQQLGNQ---------QVGVVATGNGRIISL 315 T D +I++WD++ SK +++ D G Q + + +I Sbjct: 85 LLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDF 144 Query: 316 SLDGTLNFYELGHDEVLKTISGHNKGITAL--TVNP--LISGSYDGRI---MEWSSSSMH 368 S D + ++ L + H + T +P +I G+ G + S Sbjct: 145 SNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTE 204 Query: 369 QDHSNLIVS-----LDNSKAQEYSSIS-WDDTLK 396 HS I S L S+ E +I+ D T++ Sbjct: 205 CIHSLKITSSNIKHLIVSQNGERLAINCSDRTIR 238 Score = 34.9 bits (78), Expect = 0.10, Method: Composition-based stats. Identities = 48/321 (14%), Positives = 88/321 (27%), Gaps = 58/321 (18%) Query: 156 VSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFS 215 + H + I + +T D S+ + + S + ++ Sbjct: 67 LGAHVRPITSIAWSPDG-RLLLTSSRDWSIKLWDLSKPSKPLKEIRF---DSPIWGCQWL 122 Query: 216 ------------PDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLD 263 +S +VI +D S + L D G + + Sbjct: 123 DAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDH-----GYVLVCTVHT 177 Query: 264 SQK--FATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTL 321 + + + + + K N + +V+ R+ D T+ Sbjct: 178 KHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTI 237 Query: 322 NFYELG----HDEVLKTISG-HNKGITALTVNPLI-------------SGSYDGRIMEWS 363 YE+ + V T+ + I L N ++ GS + W Sbjct: 238 RQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWE 297 Query: 364 SSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQ---------PKVASA 414 ++S +V + +E I+WD I + F S P SA Sbjct: 298 TTSG------TLVRVLEGAEEELIDINWD--FYSMSIVSNGFESGNVYVWSVVIPPKWSA 349 Query: 415 NNDGFTAVLTNDDDLLILQSF 435 F V N D L F Sbjct: 350 LAPDFEEVEENVDYLEKEDEF 370 Score = 34.9 bits (78), Expect = 0.10, Method: Composition-based stats. Identities = 23/126 (18%), Positives = 43/126 (34%), Gaps = 13/126 (10%) Query: 427 DDLLILQSFTGDIIKSV--RLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLK 484 D +L+ + ++ L + S +Y+A+G G + D++ + Sbjct: 6 DPFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANG----ALVIYDMDTFRPIC 61 Query: 485 TP-----LRAKP-SYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAIS 538 P +P + I+ SP + I L+DL F S I Sbjct: 62 VPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFD-SPIWGCQ 120 Query: 539 WKPAEK 544 W A++ Sbjct: 121 WLDAKR 126 >5OV3-A nrPDB Length = 381 Score = 50.7 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 16/72 (22%), Positives = 28/72 (38%), Gaps = 3/72 (4%) Query: 219 GEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRV 278 G + +D +I +D + K I PV ++ D K + D + Sbjct: 37 GTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWS---RDGHKLVSASTDNIVSQ 93 Query: 279 WDVTTSKCVQKW 290 WDV + C Q++ Sbjct: 94 WDVLSGDCDQRF 105 Score = 50.3 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 40/262 (15%), Positives = 76/262 (29%), Gaps = 45/262 (17%) Query: 264 SQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGR-IISLSLDGTLN 322 A D I +WD T + + + + + +G ++S S D ++ Sbjct: 37 GTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPV----CSLCWSRDGHKLVSASTDNIVS 92 Query: 323 FYELGHDEVLKTISGHNKGITALTVNPLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSK 382 +++ + + I + +P + + + S ++ + Sbjct: 93 QWDVLSGDCDQRFR-FPSPILKVQYHP----------RDQNKVLVCPMKSAPVMLTLSDS 141 Query: 383 AQEYSSISWDDTLKVNGITKHEFGSQPKVASANN-DGFTAVLTNDDDLLILQSF------ 435 + D L V F + + N G VL D L+ Sbjct: 142 KHVVLPVDDDSDLNVVA----SFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTS 197 Query: 436 TGDIIKSVRLNSPGSAVSLSQ----------NYVAVGLEEGNTIQVFKLSDLEVSFDLKT 485 IKS+ GS ++ + +G + KL DL +T Sbjct: 198 NTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVN----RT 253 Query: 486 PLRAKPSYISISPSETYIAAGD 507 P + S YI AG Sbjct: 254 PWKK----CCFSGDGEYIVAGS 271 >3I2N-A nrPDB Length = 357 Score = 50.7 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 22/167 (13%), Positives = 55/167 (32%), Gaps = 18/167 (10%) Query: 220 EFVITVGSDRKISCFDGKSGE-FLKYIEDDQEPVQGGIFALSWLDSQK---FATVGADAT 275 ++ T + ++ ++ E + ++ +E + + T D T Sbjct: 81 RYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPEIVTGSRDGT 140 Query: 276 IRVWDVT-TSKCVQKWTLDKQQL--GNQQVGV--VATGNGRIISLSLD-GTLNFYELGHD 329 ++VWD V + + V R++ D G + ++L + Sbjct: 141 VKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRNM 200 Query: 330 EVLKTISGHNKGITALTV-------NPLISGSYDGRIMEWSSSSMHQ 369 + + G+ +L N L++ S +G+ + + H Sbjct: 201 ALRWE-TNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHP 246 Score = 48.4 bits (113), Expect = 8e-06, Method: Composition-based stats. Identities = 60/392 (15%), Positives = 121/392 (30%), Gaps = 67/392 (17%) Query: 203 HKQGSFVRDVEFSPDSGEFVITVGSDR---KISCFDGKSG--EFLKYIEDDQEPVQGGIF 257 V D ++ P S +FV R I ++ + G + L+ IE +P++ G F Sbjct: 15 KGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEK-AKPIKCGTF 73 Query: 258 ALSWLDSQKFATVGADATIRVWDVTTSK-CVQKWTLDKQQLGNQQVGVVATGN---GRII 313 + L + AT + +W++ + V K+ + I+ Sbjct: 74 GATSLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPEIV 133 Query: 314 SLSLDGTLNFYELGHDE----VLKTISGHNKG-ITALTVNPLISGSYDGRIMEWSSSSMH 368 + S DGT+ ++ + ++ + G NK + ++ + Sbjct: 134 TGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFG----------------NAYN 177 Query: 369 QDHSNLIVSLDNSKAQEY----SSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLT 424 Q+ + DN + + ++ W+ +K NG+ EF K S N + Sbjct: 178 QEERVVCAGYDNGDIKLFDLRNMALRWETNIK-NGVCSLEFDR--KDISMNK---LVATS 231 Query: 425 NDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLK 484 + + T K S + S + ++F + L Sbjct: 232 LEGKFHVFDMRTQHPTKGFASVSEKAHKSTVWQVRHL----PQNRELFLTAGGAGGLHLW 287 Query: 485 TPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPAEK 544 E I + + + T I+++ W P ++ Sbjct: 288 K-------------YEYPIQRSKKDSEGIEMGVAGSVSLLQNVTLSTQPISSLDWSPDKR 334 Query: 545 GANEEEIEEDLVATGSLDTNIFIYSVKRPMKI 576 G L S D + + V + KI Sbjct: 335 G---------LCVCSSFDQTVRVLIVTKLNKI 357 Score = 47.6 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 36/278 (12%), Positives = 83/278 (29%), Gaps = 41/278 (14%) Query: 55 PVVQFTGHG---SSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSE 111 PV GH +++ +G+ + +G G V VW + + V+ E Sbjct: 103 PVYSVKGHKEIINAIDGIGGLGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGE 162 Query: 112 FQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQS 171 + ++ + + R+ G + +F +L + + + + Sbjct: 163 NKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDL--RNMALRWETNIKNGVCSLEFDRK 220 Query: 172 R--PMRSMTVGDDGSVVFYQGPPF--KFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGS 227 + + +G + + + S V V P + E +T G Sbjct: 221 DISMNKLVATSLEGKFHVFDMRTQHPTKGFASVSEKAHKSTVWQVRHLPQNRELFLTAGG 280 Query: 228 DRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCV 287 + + + ++ + D E ++ G+ L + Sbjct: 281 AGGLHLWKYEY--PIQRSKKDSEGIEMGVAGSVSL------------------------L 314 Query: 288 QKWTLDKQQLGNQQVGVVATGNGR--IISLSLDGTLNF 323 Q TL Q + + + + R + S D T+ Sbjct: 315 QNVTLSTQPIS----SLDWSPDKRGLCVCSSFDQTVRV 348 Score = 44.9 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 29/157 (18%), Positives = 63/157 (40%), Gaps = 18/157 (11%) Query: 469 IQVFKLSDLEVSFDLKTPLRAKP----SYISISPSETYIAAGDVMGKILLYDLQSREVKT 524 IQ++++ ++ L+ +AKP ++ + S + Y+A GD G + +++L++ E+ Sbjct: 46 IQLYEIQHGDLKL-LREIEKAKPIKCGTFGATSLQQRYLATGDFGGNLHIWNLEAPEMPV 104 Query: 525 SRWAFHTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHK 584 H INA G + TGS D + ++ ++ + + + Sbjct: 105 YSVKGHKEIINA----IDGIGGLGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQ 160 Query: 585 DGVNNLLWET--------PSTLVSSGADA-CIKRWNV 612 W +V +G D IK +++ Sbjct: 161 GENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDL 197 Score = 32.2 bits (71), Expect = 0.77, Method: Composition-based stats. Identities = 22/123 (17%), Positives = 50/123 (40%), Gaps = 17/123 (13%) Query: 499 SETYIAAGDVMGK---ILLYDLQSREVKTSRWAFHTSKINAISWKPAEKGANEEEIEEDL 555 S ++ G+ I LY++Q ++K R I ++ +++ Sbjct: 30 SAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKCGTF-------GATSLQQRY 82 Query: 556 VATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPS-------TLVSSGADACIK 608 +ATG N+ I++++ P + ++ HK+ +N + +V+ D +K Sbjct: 83 LATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPEIVTGSRDGTVK 142 Query: 609 RWN 611 W+ Sbjct: 143 VWD 145 >6CHG-D nrPDB Length = 439 Score = 50.3 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 35/161 (21%), Positives = 62/161 (38%), Gaps = 11/161 (6%) Query: 211 DVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWL-DSQKFAT 269 V+FSP G+++ S+ I +D S + + + + ++ W D + + Sbjct: 32 CVKFSP-RGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSVQSVCWSNDGRYLWS 90 Query: 270 VGADATIRVWDVTT-SKCVQ-------KWTLDKQQLGNQQVGVVATGNGRIISLSLDGTL 321 G D ++WD+T +KC Q W+ + V VV +++L D Sbjct: 91 SGRDWYAKLWDMTQPTKCFQQYKFDGPLWSCHVVRWNVCIVTVVEEPTAYVLTL-TDRQN 149 Query: 322 NFYELGHDEVLKTISGHNKGITALTVNPLISGSYDGRIMEW 362 F+ E + ISGH + A + S G W Sbjct: 150 AFHCFPLLEQDQDISGHGYTLVACPHPTIESIIITGTSKGW 190 Score = 49.2 bits (115), Expect = 6e-06, Method: Composition-based stats. Identities = 47/298 (15%), Positives = 97/298 (32%), Gaps = 36/298 (12%) Query: 165 ACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHK-QGSFVRDVEFSPDSGEFVI 223 ++ +G+++ Y K A TH V+ V +S D G ++ Sbjct: 32 CVKFSPRGDYLAVGCS-NGAIIIYDMDSLKPIAMLGTHSGAHTRSVQSVCWSND-GRYLW 89 Query: 224 TVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQK-FATVGADATIRVWDVT 282 + G D +D + K + Q G +++ + TV + T V +T Sbjct: 90 SSGRDWYAKLWDMT--QPTKCFQ--QYKFDGPLWSCHVVRWNVCIVTVVEEPTAYVLTLT 145 Query: 283 TSK----CVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFY------ELGHD--- 329 + C D+ G+ +VA + I S+ + GT + +L Sbjct: 146 DRQNAFHCFPLLEQDQDISGH-GYTLVACPHPTIESIIITGTSKGWINAFQLDLESGFED 204 Query: 330 --EVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKA 383 N I + ++P + D I ++ + +S + Sbjct: 205 KIRCCYEEKIANANIKQIIISPSGTRIAINGSDRTIRQYQLIVEDNESEG---GSSHSVS 261 Query: 384 QEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIK 441 E D ++ T + A+ G +A DL + ++ +G +++ Sbjct: 262 IELEHKYQDIINRLQWNTIFFSNHSGEYLVASAHGSSA-----HDLYLWETSSGSLVR 314 Score = 38.0 bits (86), Expect = 0.012, Method: Composition-based stats. Identities = 21/108 (19%), Positives = 42/108 (38%), Gaps = 15/108 (13%) Query: 471 VFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQS--REVKTSRWA 528 V K +++ L+ P+ A + SP Y+A G G I++YD+ S + Sbjct: 12 VLKEYPEKLTHTLEVPVAA--VCVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHS 69 Query: 529 F-HTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMK 575 HT + ++ W + + + D ++ + +P K Sbjct: 70 GAHTRSVQSVCWSNDGRY----------LWSSGRDWYAKLWDMTQPTK 107 >3EI3-B nrPDB Length = 383 Score = 49.5 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 25/181 (13%), Positives = 51/181 (28%), Gaps = 18/181 (9%) Query: 159 HSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDS 218 H ++ T D +V + K S V F+P Sbjct: 203 HKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNAAYFNPTD 262 Query: 219 GEFVITVGSDRKISCFDG--------------KSGEFLKYIEDDQEPVQGGIFALSWLDS 264 ++T +I + + + L I+ P+ I A + D Sbjct: 263 STKLLTTDQRNEIRVYSSYDWSKPDQIIIHPHRQFQHLTPIKATWHPMYDLIVAGRYPDD 322 Query: 265 QKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFY 324 Q TI ++D + V + D G + + G +++ + + + Sbjct: 323 QLLL--NDKRTIDIYDANSGGLVHQLR-DPNAAGIISLN-KFSPTGDVLASGMGFNILIW 378 Query: 325 E 325 Sbjct: 379 N 379 Score = 49.5 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 28/216 (12%), Positives = 69/216 (31%), Gaps = 21/216 (9%) Query: 161 QRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGE 220 +R+ + + P G ++ + ++ + G + ++F+ + Sbjct: 74 RRVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGM-GPGDAITGMKFNQFNTN 132 Query: 221 FVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDS----QKFATVGADATI 276 + + D SG ++ + +D Q AT D+T Sbjct: 133 QLFVSSIRGATTLRDF-SGSVIQVFAKT----DSWDYWYCCVDVSVSRQMLATG--DSTG 185 Query: 277 RVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTIS 336 R+ + + + + + + + S+D T+ ++L + + + Sbjct: 186 RL-LLLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYI 244 Query: 337 G---HNKGITALTVNP-----LISGSYDGRIMEWSS 364 H K + A NP L++ I +SS Sbjct: 245 AEMPHEKPVNAAYFNPTDSTKLLTTDQRNEIRVYSS 280 Score = 46.1 bits (107), Expect = 5e-05, Method: Composition-based stats. Identities = 47/347 (13%), Positives = 110/347 (31%), Gaps = 39/347 (11%) Query: 189 QGPPFKFSASDRTHHKQGSF---VRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYI 245 Q P + S + H F V +E+ P V I +D +I Sbjct: 53 QEPFIRSLKSYKLHRTASPFDRRVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFI 112 Query: 246 EDDQEP--VQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVG 303 + + G F + +++ T+R + + +Q + Sbjct: 113 QGMGPGDAITGMKFNQFNTNQLFVSSIRGATTLRDF---SGSVIQVFAK-TDSWDYWYCC 168 Query: 304 VVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP-----LISGSYDGR 358 V + + ++++ + H +T NP + + S D Sbjct: 169 VDVSVSRQMLATGDSTGRLLLLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDAT 228 Query: 359 IMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDG 418 + W +D ++ I + + K + + D+ K+ + + Sbjct: 229 VKLWD-LRNIKDKNSYIAEMPHEKPVNAAYFNPTDSTKL--------------LTTDQRN 273 Query: 419 FTAVLTND-----DDLLILQSFTGDIIKSVRLN-SPGSAVSLSQNY--VAVGLEEGNTIQ 470 V ++ D ++I + ++ P + ++ Y + L + TI Sbjct: 274 EIRVYSSYDWSKPDQIIIHPHRQFQHLTPIKATWHPMYDLIVAGRYPDDQLLLNDKRTID 333 Query: 471 VFKLSDLEVSFDLKTPLRAKPSYI-SISPSETYIAAGDVMGKILLYD 516 ++ + + L+ P A + SP+ +A+G IL+++ Sbjct: 334 IYDANSGGLVHQLRDPNAAGIISLNKFSPTGDVLASGMGFN-ILIWN 379 >5AMS-A nrPDB Length = 431 Score = 48.4 bits (113), Expect = 8e-06, Method: Composition-based stats. Identities = 45/336 (13%), Positives = 101/336 (30%), Gaps = 37/336 (11%) Query: 103 SVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSG--NSLGEVSGHS 160 + N + F + I +C G DN + S G ++G+ Sbjct: 52 DMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGG--DNLAHLWTSHSQPPKFAGTLTGYG 109 Query: 161 QRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGE 220 + + +C T G V+ + G + ++ + ++ P Sbjct: 110 ESVISCSFTSEGGFLV-TADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIAR 168 Query: 221 FVITVGSDRKISCF--DGKSGEFLKYIED--DQEPVQGGIFALSWL--DSQKFATVGADA 274 +D + C+ + + G + + Q+ G F + ++ + T D+ Sbjct: 169 TFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDS 228 Query: 275 TIRVWDVTTSKCVQKWTLDK--------QQLGNQQVGVVATGNGRIISLSLDGTLNFYEL 326 TI W+ T + + K T + L + +G + S +G L Sbjct: 229 TIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINC 288 Query: 327 GHD------EVLKTISGHNKGI--------TALTVNPLISGSYDGRIMEWSSSSMHQDH- 371 + + + + + + + G G I+ + +S+ H Sbjct: 289 NNGGAILHLSTVIELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYDTSAWRVRHK 348 Query: 372 ---SNLIVSLDNSKAQEYSSISWDDTLKVNGITKHE 404 + + L ++S + N T E Sbjct: 349 FVLEDSVTKLMFDNDDLFASCINGKVYQFNARTGQE 384 Score = 34.5 bits (77), Expect = 0.14, Method: Composition-based stats. Identities = 34/225 (15%), Positives = 69/225 (30%), Gaps = 28/225 (12%) Query: 363 SSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAV 422 +S + H++ + ++ + D L SQP F Sbjct: 56 NSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNL----AHLWTSHSQPP-------KFAGT 104 Query: 423 LTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFD 482 LT + +I SFT + V + G + ++G EV Sbjct: 105 LTGYGESVISCSFTSEGGFLVTADMSGKVL-------VHMGQKGGAQWKLASQMQEVEEI 157 Query: 483 LKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFHTSKINAISWKPA 542 + L+ P+ A G G + Y + ++ + + ++ Sbjct: 158 VW--LKTHPTI------ARTFAFGATDGSVWCYQINEQDGSLEQLM--SGFVHQQDCSMG 207 Query: 543 EKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGV 587 E ++ + T SLD+ I ++ ++ K A G+ Sbjct: 208 EFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGL 252 >5WLC-LS nrPDB Length = 594 Score = 47.2 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 57/377 (15%), Positives = 122/377 (32%), Gaps = 43/377 (11%) Query: 178 TVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCF--D 235 T+ + + + + ++ +H + ++ + F P ++T G D+ + + D Sbjct: 221 TLSNSKLLPPKKLDIVRLKDANASHPSHSA-IQSLSFHPSK-PLLLTGGYDKTLRIYHID 278 Query: 236 GKSGEFLKYIEDDQEPVQGGIF--ALSWLDSQKFATVGADATIRVWDV--------TTSK 285 GK+ + + P+Q F +LS + Q T G + WD+ T+K Sbjct: 279 GKTNHLVTSLHLVGSPIQTCTFYTSLSNQNQQNIFTAGRRRYMHSWDLSLENLTHSQTAK 338 Query: 286 CVQKWTLDKQQL----------GNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTI 335 + L + + Q + +G ++ +G +N L L + Sbjct: 339 IEKFSRLYGHESTQRSFENFKVAHLQNSQTNSVHGIVLLQGNNGWINI--LHSTSGLWLM 396 Query: 336 SGHNKGIT---ALTVNPLISGSY-------DGRIMEWSSSSMHQDHSNLIVSLDNSKAQE 385 +G+ + P+ G + + W H Sbjct: 397 GCKIEGVITDFCIDYQPISRGKFRTILIAVNAYGEVWEFDLNKNGHVIRRWKDQGGVGIT 456 Query: 386 YSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRL 445 + T + + +A + GF + D + + S + +L Sbjct: 457 KIQVGGGTTTTCPALQISKIKQNRWLAVGSESGFVNLY--DRNNAMTSSTPTPVAALDQL 514 Query: 446 NSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDL-EVSFDLKTPLRAKP----SYISISPSE 500 + S + S + + + +L L S P P + ++ SPS Sbjct: 515 TTTISNLQFSPDGQILCMASRAVKDALRLVHLPSCSVFSNWPTSGTPLGKVTSVAFSPSG 574 Query: 501 TYIAAGDVMGKILLYDL 517 +A G+ GK+ L+ L Sbjct: 575 GLLAVGNEQGKVRLWKL 591 Score = 36.1 bits (81), Expect = 0.047, Method: Composition-based stats. Identities = 49/357 (13%), Positives = 122/357 (34%), Gaps = 46/357 (12%) Query: 251 PVQGGIFALSWLDSQKFA-TVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGN 309 P I +LS+ S+ T G D T+R++ + +L Q + + Sbjct: 246 PSHSAIQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFYTSLS 305 Query: 310 GR----IISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPLISGSYDGRIMEWSSS 365 + I + ++ ++L + + + + + + L + S++ + + Sbjct: 306 NQNQQNIFTAGRRRYMHSWDLSLENLTHSQTAKIEKFSRLYGHESTQRSFENFKVAHLQN 365 Query: 366 SMHQDHSNLI--------VSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPK----VAS 413 S ++ +++ +S + + + + + ++ S+ K + + Sbjct: 366 SQTNSVHGIVLLQGNNGWINILHSTSGLWLMGCKIEGVITDFCIDYQPISRGKFRTILIA 425 Query: 414 ANNDGFT---AVLTNDDDLLILQSFTGDIIKSVRL----NSPGSAVSLSQNYVAVGLEEG 466 N G + N + + G I +++ + A+ +S+ L G Sbjct: 426 VNAYGEVWEFDLNKNGHVIRRWKDQGGVGITKIQVGGGTTTTCPALQISKIKQNRWLAVG 485 Query: 467 NTIQVFKLSDLEVSFDLKTP--------LRAKPSYISISPSETYI--AAGDVMGKILLYD 516 + L D + TP L S + SP + A+ V + L Sbjct: 486 SESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAVKDALRLVH 545 Query: 517 LQSREVKTSRWAFHT--SKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVK 571 L S V ++ T K+ ++++ P+ L+A G+ + ++ + Sbjct: 546 LPSCSVFSNWPTSGTPLGKVTSVAFSPS----------GGLLAVGNEQGKVRLWKLN 592 Score = 34.5 bits (77), Expect = 0.12, Method: Composition-based stats. Identities = 28/142 (19%), Positives = 56/142 (39%), Gaps = 21/142 (14%) Query: 61 GHGSSVVT-TVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPI 119 G G++ ++ S IK +++L G ESG V ++ + S + L I Sbjct: 461 GGGTTTTCPALQISKIKQNRWLAVGSESGFVNLYDR--NNAMTSSTPTPVAALDQLTTTI 518 Query: 120 SDISWDFEGRRLCVVGEG---------RDNFGVFISW-DSGNSLGEVSGHSQRINACHLK 169 S++ + +G+ LC+ + VF +W SG LG+ + + Sbjct: 519 SNLQFSPDGQILCMASRAVKDALRLVHLPSCSVFSNWPTSGTPLGK-------VTSVAFS 571 Query: 170 QSRPMRSMTVGDDGSVVFYQGP 191 S + ++ + G V ++ Sbjct: 572 PSGGLLAV-GNEQGKVRLWKLN 592 >5TF2-A nrPDB Length = 407 Score = 47.2 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 16/86 (18%), Positives = 39/86 (45%), Gaps = 4/86 (4%) Query: 240 EFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGN 299 E L+ ++ D D+ AT G D +RVW V + + V ++ + ++ + Sbjct: 160 ENLQAVQTDFSSDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIED 219 Query: 300 QQVGVVATGNGRIISLSLDGTLNFYE 325 +G +G+++++ D + ++ Sbjct: 220 LALG----PDGKLVTVGRDLKASVWQ 241 Score = 42.2 bits (97), Expect = 6e-04, Method: Composition-based stats. Identities = 13/66 (19%), Positives = 25/66 (37%), Gaps = 3/66 (4%) Query: 300 QQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP---LISGSYD 356 Q+V N + + DG + +++ E + H I L + P L++ D Sbjct: 175 QKVVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGKLVTVGRD 234 Query: 357 GRIMEW 362 + W Sbjct: 235 LKASVW 240 Score = 40.7 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 16/74 (21%), Positives = 26/74 (35%), Gaps = 4/74 (5%) Query: 206 GSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQ 265 ++ V + T G+D + + S E + + +G I L+ Sbjct: 171 SDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAH----EGEIEDLALGPDG 226 Query: 266 KFATVGADATIRVW 279 K TVG D VW Sbjct: 227 KLVTVGRDLKASVW 240 Score = 36.4 bits (82), Expect = 0.034, Method: Composition-based stats. Identities = 15/59 (25%), Positives = 27/59 (45%), Gaps = 1/59 (1%) Query: 552 EEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSGADACIKRW 610 + L+ATG D + ++ V K+++ AH+ + +L LV+ G D W Sbjct: 183 DNTLLATGGTDGYVRVWKVPSLEKVLE-FKAHEGEIEDLALGPDGKLVTVGRDLKASVW 240 >2VDU-B nrPDB Length = 450 Score = 46.8 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 34/178 (19%), Positives = 60/178 (33%), Gaps = 20/178 (11%) Query: 77 GSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGE 136 S+ + D ++V FD + S V + + + IS + + + Sbjct: 114 ESRLIACADSDKSLLV----FDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIA-- 167 Query: 137 GRDNFGVFISWDSGNSLGE------VSGHSQRINACHL--KQSRPMRSMTVGDDGSVVFY 188 D FG S D + E + GH + HL +T D + Sbjct: 168 --DKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKIS 225 Query: 189 QGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIE 246 P + D+ FV + D +++ G D KI +D K+G+ L + Sbjct: 226 HYP--QCFIVDKWLFGHKHFVSSICCGKDY--LLLSAGGDDKIFAWDWKTGKNLSTFD 279 Score = 43.8 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 32/191 (16%), Positives = 55/191 (28%), Gaps = 24/191 (12%) Query: 113 QVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSR 172 + I ++ + RL + D + D S + + + R Sbjct: 99 PPIYSYIRNLRLTSDESRL-IACADSDKSLLVFDVDK-TSKNVLKLRKRFCFS-----KR 151 Query: 173 PMRSMTVGDDGSVVFYQGPPFKFSASDRTHH----------KQGSFVRDVEFSPDS--GE 220 P DD +V+ +S + S + DV DS + Sbjct: 152 PNAISIAEDDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQ 211 Query: 221 FVITVGSDRKISCFDGKSGEFL-KYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVW 279 F+IT D I + K++ + V D + G D I W Sbjct: 212 FIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSI---CCGKDYL-LLSAGGDDKIFAW 267 Query: 280 DVTTSKCVQKW 290 D T K + + Sbjct: 268 DWKTGKNLSTF 278 Score = 36.4 bits (82), Expect = 0.034, Method: Composition-based stats. Identities = 41/242 (16%), Positives = 80/242 (33%), Gaps = 18/242 (7%) Query: 381 SKAQEYSSISWDDTL-KVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFT--- 436 S + W D K+ Q +S N + + +N D + + Sbjct: 34 SPNHWEFAGKWSDDFDKIQESRNTTAKEQQGQSSENENENKKLKSNKGDSIKRTAAKVPS 93 Query: 437 -GDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVF---KLSDLEVSFDLKTPLRAKPS 492 G + ++ ++ + + ++ VF K S + + +P+ Sbjct: 94 PGLGAPPIYSYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPN 153 Query: 493 YISISPSETYIAAGDVMGKILLYDLQS---REVKTSRWAFHTSKINAISWKPAEKGANEE 549 ISI+ +T + D G + D+ S + H S + + G Sbjct: 154 AISIAEDDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQ-- 211 Query: 550 EIEEDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSGADACIKR 609 + T D +I I + + K L HK V+++ L+S+G D I Sbjct: 212 -----FIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIFA 266 Query: 610 WN 611 W+ Sbjct: 267 WD 268 Score = 32.2 bits (71), Expect = 0.62, Method: Composition-based stats. Identities = 17/153 (11%), Positives = 48/153 (31%), Gaps = 9/153 (5%) Query: 71 KFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQ-----VLAGPISDISWD 125 +F K + ++ VI+ D S + + +F ++D+ Sbjct: 145 RFCFSKRPNAISIAEDDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLI 204 Query: 126 FEGR-RLCVVGEGRDNFGVFISWDSGNSL-GEVSGHSQRINACHLKQSRPMRSMTVGDDG 183 + ++ RD + + + GH ++ + + ++ G D Sbjct: 205 KDSDGHQFIITSDRDEHIKISHYPQCFIVDKWLFGHKHFVS--SICCGKDYLLLSAGGDD 262 Query: 184 SVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSP 216 + + K ++ + ++ D +P Sbjct: 263 KIFAWDWKTGKNLSTFDYNSLIKPYLNDQHLAP 295 >5M89-A nrPDB Length = 329 Score = 45.3 bits (105), Expect = 7e-05, Method: Composition-based stats. Identities = 38/250 (15%), Positives = 79/250 (31%), Gaps = 41/250 (16%) Query: 258 ALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSL 317 + L+++ A G D + ++ V +K + +G TG +++ + Sbjct: 57 SSLDLENECAAVGGLDGKLDIYSVVANKVERTL-----DIGEPVTATEWTG-TKVVIGTA 110 Query: 318 DGTLNFYELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSM------ 367 G + Y+ T H +T L V+P L S D + + + Sbjct: 111 KGWVKVYD--AGRESATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGERVARG 168 Query: 368 -----------HQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANN 416 H D + + + + + G+ + + + Sbjct: 169 YADAALTTCAFHPDGNLFAAGTQTGHILVFHTTT------LEQAESFPLGTPIQALAFSE 222 Query: 417 DGFTAVLTND--DDLLILQSFTGDIIKSVRLNSPGSAVSLS----QNYVAVGLEEGNTIQ 470 +GF T + I +V+ G +S+S Y+A G G T+Q Sbjct: 223 NGFWFAATGKGTSSVTIFDLRKSGAAAAVKELQTGEVLSISWDYTGQYLATGGGTGVTVQ 282 Query: 471 VFKLSDLEVS 480 ++ + S Sbjct: 283 MYTKATKSWS 292 Score = 40.7 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 45/291 (15%), Positives = 89/291 (30%), Gaps = 33/291 (11%) Query: 44 RCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNS 103 + + + P T + + V ++ + +Q E+ V G + S Sbjct: 20 QLMKTRKKRPIPQGWATADDVAALQQVAYTDLNVTQASSLDLENECAAVGGLDGKLDIYS 79 Query: 104 VEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRI 163 V N + P++ W + G +D+G H+ + Sbjct: 80 VVANKVERTLDIGEPVTATEWTGTKVVIGTA------KGWVKVYDAGRESATFQTHAGPV 133 Query: 164 NACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVI 223 + + + +VG D S VFY + + + F PD G Sbjct: 134 TGLAVHPGGRILA-SVGVDKSFVFYDLETGE----RVARGYADAALTTCAFHPD-GNLFA 187 Query: 224 TVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQ--KFATVGADATIRVWDV 281 I F + E + P+ I AL++ ++ AT +++ ++D+ Sbjct: 188 AGTQTGHILVFHTTTLEQAESF-----PLGTPIQALAFSENGFWFAATGKGTSSVTIFDL 242 Query: 282 TTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVL 332 S V G ++S+S D T + G + Sbjct: 243 RKS--------------GAAAAVKELQTGEVLSISWDYTGQYLATGGGTGV 279 Score = 35.3 bits (79), Expect = 0.084, Method: Composition-based stats. Identities = 34/223 (15%), Positives = 75/223 (33%), Gaps = 36/223 (16%) Query: 416 NDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLS 475 + AV D L I + +++ + P +A + V +G +G ++V+ Sbjct: 62 ENECAAVGGLDGKLDIYSVVANKVERTLDIGEPVTATEWTGTKVVIGTAKG-WVKVYDAG 120 Query: 476 DLEVSFDLKTPLRAKP-SYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWA------ 528 +F A P + +++ P +A+ V + YDL++ E +A Sbjct: 121 RESATFQT----HAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGERVARGYADAALTT 176 Query: 529 ---------------------FHTSKINAISWKPAEKGANEEEIEED---LVATGSLDTN 564 FHT+ + P E+ ATG ++ Sbjct: 177 CAFHPDGNLFAAGTQTGHILVFHTTTLEQAESFPLGTPIQALAFSENGFWFAATGKGTSS 236 Query: 565 IFIYSVKRPMKIIKALNAHKDGVNNLLWETPSTLVSSGADACI 607 + I+ +++ V ++ W+ +++G + Sbjct: 237 VTIFDLRKSGAAAAVKELQTGEVLSISWDYTGQYLATGGGTGV 279 >5MC6-j nrPDB Length = 397 Score = 44.1 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 33/207 (15%), Positives = 72/207 (34%), Gaps = 42/207 (20%) Query: 52 KVPPVVQFTGHGSSVVTTVKFSP---IKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNV 108 P ++ G S +T +F+ I + +G +G V + + + + E Sbjct: 168 NWSPTLELQGTVESPMTPSQFATSVDISERGLIATGFNNGTVQISELSTLRPLYNFES-- 225 Query: 109 KSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDS--GNSLGEVSGHSQRINAC 166 + + I + + +G L + ++FG +++ G +G +S Sbjct: 226 QHSMINNSNSIRSVKFSPQGSLLAIA-HDSNSFGCITLYETEFGERIGSLS--------- 275 Query: 167 HLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVG 226 P S + S+V + F+ DSGE + + G Sbjct: 276 ------------------------VPTHSSQASLGEFAHSSWVMSLSFN-DSGETLCSAG 310 Query: 227 SDRKISCFDGKSGEFLKYIEDDQEPVQ 253 D K+ +D K+ E + + + ++ Sbjct: 311 WDGKLRFWDVKTKERITTLNMHCDDIE 337 Score = 43.4 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 43/333 (12%), Positives = 98/333 (29%), Gaps = 46/333 (13%) Query: 56 VVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVL 115 V T + FS + + S G + VW N + + Sbjct: 4 VFIATANAGKAHDADIFSVSACNSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKS 63 Query: 116 AGPISDI--SWDFEGRRLCVVGEG------------RDNFGVFISWDSGNSLGE-VSGHS 160 D+ + + + LC+V R++ + ++ + L + HS Sbjct: 64 GLHHVDVLQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHS 123 Query: 161 QRINACHLKQSRPMRSMTVGDD--GSVVFYQGPPFK------FSASDRTHHKQGSFVRDV 212 R + V D G+ ++ PF T QG+ + Sbjct: 124 FWALKWGASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPM 183 Query: 213 EFSPDSGE-------FVITVGSDRKISCFDGKSGEFLKYIEDDQEPV--QGGIFALSWLD 263 S + + T ++ + + + L E + I ++ + Sbjct: 184 TPSQFATSVDISERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSP 243 Query: 264 SQKFATVGADAT----IRVWDVTTSKCVQKWTLDKQQ---------LGNQQVGVVATGNG 310 + D+ I +++ + + ++ + + + +G Sbjct: 244 QGSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSG 303 Query: 311 -RIISLSLDGTLNFYELGHDEVLKTISGHNKGI 342 + S DG L F+++ E + T++ H I Sbjct: 304 ETLCSAGWDGKLRFWDVKTKERITTLNMHCDDI 336 >2I3T-A nrPDB Length = 341 Score = 43.8 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 40/223 (17%), Positives = 68/223 (30%), Gaps = 26/223 (11%) Query: 77 GSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFE---GRRLCV 133 G L + G + V D + V + + + + R + Sbjct: 111 GDDKLIAASWDGLIEV----IDPRNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVG 166 Query: 134 VGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVV--FYQGP 191 + + + + N E SG +I L DG V F+ Sbjct: 167 MNNSQVQWFRLPLCEDDNGTIEESGLKYQIRDVALLPKEQEGYACSSIDGRVAVEFFDDQ 226 Query: 192 PFKFSASDR-THHKQ---------GSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEF 241 +++S R V +EFSP +F+ T GSD ISC++ ++ + Sbjct: 227 GDDYNSSKRFAFRCHRLNLKDTNLAYPVNSIEFSP-RHKFLYTAGSDGIISCWNLQTRKK 285 Query: 242 LKYIEDDQEP------VQGGIFALSWLDSQKFATVGADATIRV 278 +K E I L+ D D TI + Sbjct: 286 IKNFAKFNEDSVVKIACSDNILCLATSDDTFKTNAAIDQTIEL 328 >5WLC-LH nrPDB Length = 896 Score = 43.8 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 53/310 (17%), Positives = 122/310 (39%), Gaps = 20/310 (6%) Query: 213 EFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGA 272 S D ++I + +I + ++ + +K ++ + GIF +++ + Sbjct: 36 RLSQDQRNYIIP--FNNQIKVYSVETRQCVKTLKFANNSLLSGIFLQEEENNESIVKILL 93 Query: 273 DATIRVWDVTTSKCVQKWTLDKQQLG-NQQVGVVATGNGRIISLSLDGTLN-FYELGHDE 330 I V + + +T + + N + +V + ISL+ + N F+ G+ Sbjct: 94 -GDITVPQQEDAHLITVFTNNGHVIVLNYKGKLVESPKHFKISLADEKLANVFHSEGNYR 152 Query: 331 VLKTISG-HNKGITALTVNPLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSI 389 +L T K +L L + ++D ++ + + H+ ++ ++ +S + + + Sbjct: 153 ILTTFKDPSQKAHNSLQSYRLYALTFDDAKKQFEVAHQAEWHNVILSNI-SSNGKLLAHM 211 Query: 390 SWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPG 449 D + K + K S + +V + IL S T + + R S Sbjct: 212 CKDVSTK---------DHEHKSISVVSLFDDSVNLSFPLGSILSSQTQSLSYNTRYVSSM 262 Query: 450 SAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVM 509 + ++ Q +AVG G I + L+DL++ +S S +Y+ +G Sbjct: 263 AIDNMGQQ-LAVGFASG-VISIVSLADLQIRLLKWHI--DSVLSLSFSHDGSYLLSGGWE 318 Query: 510 GKILLYDLQS 519 + L+ L++ Sbjct: 319 KVMSLWQLET 328 Score = 34.5 bits (77), Expect = 0.15, Method: Composition-based stats. Identities = 22/140 (15%), Positives = 54/140 (38%), Gaps = 13/140 (9%) Query: 107 NVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGE----VSGHSQR 162 N+ S ++LA D+S + V D+ V +S+ G+ L +S +++ Sbjct: 200 NISSNGKLLAHMCKDVSTKDHEHKSISVVSLFDD-SVNLSFPLGSILSSQTQSLSYNTRY 258 Query: 163 INACHLKQSRPMRSMT-VGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEF 221 +++ + ++ S+V + V + FS D G + Sbjct: 259 VSSMAIDNMGQQLAVGFASGVISIVSLADLQIRLLKW------HIDSVLSLSFSHD-GSY 311 Query: 222 VITVGSDRKISCFDGKSGEF 241 +++ G ++ +S + ++ Sbjct: 312 LLSGGWEKVMSLWQLETNSQ 331 >5WLC-LW nrPDB Length = 554 Score = 42.2 bits (97), Expect = 6e-04, Method: Composition-based stats. Identities = 27/148 (18%), Positives = 53/148 (35%), Gaps = 10/148 (6%) Query: 174 MRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISC 233 +T G+ G + ++ + + RT + +P + S+ +S Sbjct: 203 YLLVTAGETGWLKYHDVSTGQLVSELRTKAGPT---MAMAQNP-WNAVMHLGHSNGTVSL 258 Query: 234 FDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSK---CVQKW 290 + E L + + PV S AT GAD ++++WD+ K V+ Sbjct: 259 WSPSMPEPLVKLLSARGPVNSIAIDRS---GYYMATTGADRSMKIWDIRNFKQLHSVESL 315 Query: 291 TLDKQQLGNQQVGVVATGNGRIISLSLD 318 + G++A G ++L D Sbjct: 316 PTPGTNVSISDTGLLALSRGPHVTLWKD 343 Score = 36.8 bits (83), Expect = 0.028, Method: Composition-based stats. Identities = 19/131 (14%), Positives = 45/131 (34%), Gaps = 10/131 (7%) Query: 149 SGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSF 208 +G + E+ + A + + +G+V + + + + Sbjct: 221 TGQLVSELRTKAGPTMAMAQNPWNAVMHL-GHSNGTVSLWSPSMPEPLVKLLSARGPVNS 279 Query: 209 VRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFA 268 + SG ++ T G+DR + +D ++ + L +E P S D+ A Sbjct: 280 IA----IDRSGYYMATTGADRSMKIWDIRNFKQLHSVESLPTPGTNV----SISDTGLLA 331 Query: 269 TVGADATIRVW 279 + + +W Sbjct: 332 -LSRGPHVTLW 341 >5LTD-A nrPDB Length = 525 Score = 41.8 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 30/176 (17%), Positives = 65/176 (36%), Gaps = 23/176 (13%) Query: 358 RIMEWSSSSMHQDHS-------NLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPK 410 I + ++M H+ N +++L S Y + L N T+ S P+ Sbjct: 138 TIYIYDINNMRLLHTIETPSNPNGLIALSPSSENNYLAYPSPQKLAPNPQTEVTLHSNPQ 197 Query: 411 VASANNDGFTAVLTNDDDLLILQSFT---GDIIKSVRLNSPGSAVSLSQNYVAVGLEEGN 467 D++I + T +I++ R + A+S +A ++G Sbjct: 198 TVRNG------------DVIIFDAKTLQPTSVIEAHRTSLAAIALSKDGLLLATASDKGT 245 Query: 468 TIQVFKLS-DLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREV 522 I+VF ++ +++ + K ++ SP ++ A + ++ L E Sbjct: 246 IIRVFSVATGIKLYQFRRGTYPTKIYSLAFSPDNRFVIASSATETVHIFRLGEEEA 301 >6CVZ-A nrPDB Length = 351 Score = 39.5 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 20/125 (16%), Positives = 44/125 (35%), Gaps = 10/125 (8%) Query: 231 ISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKW 290 + + + +YI + ++G F+ + D TI++ + T+ VQ + Sbjct: 56 VKMLSTANMKSSQYIPMHGKQIRGLAFSSYLR--GLLLSASLDNTIKLTSLETNTVVQTY 113 Query: 291 TLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPL 350 I + +G++ Y++ + T S + + PL Sbjct: 114 ---NAGRPVWSCCWCLDEANYIYAGLANGSILVYDVRN-----TSSHVQELVAQKARCPL 165 Query: 351 ISGSY 355 +S SY Sbjct: 166 VSLSY 170 Score = 34.5 bits (77), Expect = 0.14, Method: Composition-based stats. Identities = 9/88 (10%), Positives = 25/88 (28%), Gaps = 4/88 (4%) Query: 151 NSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVR 210 S + H ++I ++ D ++ + G V Sbjct: 65 KSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNA----GRPVW 120 Query: 211 DVEFSPDSGEFVITVGSDRKISCFDGKS 238 + D ++ ++ I +D ++ Sbjct: 121 SCCWCLDEANYIYAGLANGSILVYDVRN 148 >5CWW-B nrPDB Length = 595 Score = 35.7 bits (80), Expect = 0.060, Method: Composition-based stats. Identities = 34/198 (17%), Positives = 64/198 (32%), Gaps = 20/198 (10%) Query: 95 WTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFI----SWDSG 150 + + + V + ++ GP I+ G + V + +G SW+S Sbjct: 22 FAPAADDGTATVPLAYGKKIKPGPRRTIA--RRGTEIFVACGKQIRWGDLAQLKESWESR 79 Query: 151 NSLGEVSGHSQRINACHLKQSRP---MRSM-TVGDDGSVVFYQGPPFKFSASDRTHHKQG 206 S V S + ++ R + T D P F A +H Sbjct: 80 PSRSSVGPTSTKKDSSDFDDGAATAGYRIIKTPVADDIRQLVMSPNQDFLAVLTSHTVHI 139 Query: 207 SFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQK 266 + PDS I + K + + + V ++ ++ Sbjct: 140 CIL------PDSSHLHIQDTTPFKPKFWTLGPTTHVTS----RSAVVSAVWHPLGVNGHA 189 Query: 267 FATVGADATIRVWDVTTS 284 TV DA +RVW+++T+ Sbjct: 190 LVTVTEDAIVRVWELSTA 207 >6N8P-A nrPDB Length = 979 Score = 34.5 bits (77), Expect = 0.14, Method: Composition-based stats. Identities = 30/236 (12%), Positives = 66/236 (27%), Gaps = 32/236 (13%) Query: 74 PIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCV 133 + + L S G W + + + ++ I+ I W Sbjct: 227 WQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLRSLVPYGPFPCKAITRILWLTT------ 280 Query: 134 VGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPF 193 G+ + G G I+ H Q + +V+ P Sbjct: 281 ------RQGLPFTIFQGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAA 334 Query: 194 KF--SASDRTHHKQGSFVRDVE---FSPDSGEFVITVGSDRK----------ISCFD--G 236 F + ++ V D++ + P ++ ++ + ++ Sbjct: 335 TFDDPYALVVLAEEELVVIDLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERII 394 Query: 237 KSGE-FLKYIEDDQEPVQGGI-FALSWLDSQKFATVGADATIRVWDVTTSKCVQKW 290 +G + + P+ GG + T D T+R WD + C++ Sbjct: 395 AAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGHEDGTVRFWD-ASGVCLRLL 449 Score = 33.4 bits (74), Expect = 0.28, Method: Composition-based stats. Identities = 14/65 (21%), Positives = 21/65 (32%), Gaps = 5/65 (7%) Query: 164 NACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVI 223 + + +T +DG+V F+ R +K S VR D E Sbjct: 415 TSLTPAPPQRDLLLTGHEDGTVRFWDA----SGVCLRLLYK-LSTVRVFLTDTDPNENFS 469 Query: 224 TVGSD 228 G D Sbjct: 470 AQGED 474 Score = 31.8 bits (70), Expect = 0.79, Method: Composition-based stats. Identities = 38/255 (14%), Positives = 79/255 (30%), Gaps = 44/255 (17%) Query: 10 IPPQPSTQRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTG--HGSSVV 67 P QPS L Y P+ +A +S ++ P V+F G ++ V Sbjct: 20 FPHQPSA-------LGYSPSLRILAIGT-RSGAIKLYG------APGVEFMGLHQENNAV 65 Query: 68 TTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGP------ISD 121 T + P G L + + + +W ++ ++ + + G I+ Sbjct: 66 TQIHLLP--GQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITV 123 Query: 122 ISWDFEGRRLCVVGEGRDNFGVFI---------SWDSGNSLGEVSGHSQR------INAC 166 + L + E + F V + + S L + ++ + A Sbjct: 124 VLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEMVEAL 183 Query: 167 HLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVG 226 P + + G VV + + H + ++ + D G +++ Sbjct: 184 QEHPRDPNQILIGYSRGLVVIWDLQ----GSRVLYHFLSSQQLENIWWQRD-GRLLVSCH 238 Query: 227 SDRKISCFDGKSGEF 241 SD + S Sbjct: 239 SDGSYCQWPVSSEAQ 253 Score = 31.8 bits (70), Expect = 0.94, Method: Composition-based stats. Identities = 8/64 (12%), Positives = 25/64 (39%), Gaps = 5/64 (7%) Query: 276 IRVWD----VTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEV 331 +++W+ + + T++ G + +++ DGT+ F++ Sbjct: 387 LKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGHEDGTVRFWD-ASGVC 445 Query: 332 LKTI 335 L+ + Sbjct: 446 LRLL 449 >2VR2-A nrPDB Length = 541 Score = 33.0 bits (73), Expect = 0.40, Method: Composition-based stats. Identities = 17/100 (17%), Positives = 29/100 (29%), Gaps = 1/100 (1%) Query: 177 MTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDG 236 + +D V ++ + S F+ + I VGSD I +D Sbjct: 371 VNGVEDRMSVIWEKGVHSGKMDENRFVAVTSTNAAKIFNLYPRKGRIAVGSDADIVIWDP 430 Query: 237 KSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATI 276 K G + + V IF T+ + Sbjct: 431 K-GTRTISAKTHHQAVNFNIFEGMVCHGVPLVTISRGKVV 469 >4IMM-A nrPDB Length = 399 Score = 33.0 bits (73), Expect = 0.43, Method: Composition-based stats. Identities = 45/293 (15%), Positives = 84/293 (28%), Gaps = 55/293 (18%) Query: 122 ISWDFEGRRLCVVGEGRDNFGVFISW--DSGNSLGEV--SGHSQRINACHLKQSRPMRS- 176 I+W + + G G D+ G SG + +G ++ + P Sbjct: 101 IAWQYNAEDVITGGVGIDDQGSVAVIGTRSGKLIALDARTGAARWVVELASSSLAPALIS 160 Query: 177 ----MTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFS-PDSGEFVITVGSDRKI 231 + + + G++ + VR + V+ G+D +I Sbjct: 161 GDKVIVITNSGTIFGLDINSGAT-VWQYATQVPNTSVRGMAKPLALDARTVLIGGADGRI 219 Query: 232 SCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQ------KFATVGADATIRVWDVTTSK 285 D +G + G I L +D + +D+TT + Sbjct: 220 HALDTMTGAPVWTRRVGLAMGSGEIDQLRDIDGTPTVVDHYLYAASYSGQLAGFDMTTGR 279 Query: 286 CV------------------------------QKWTLDK----QQLGNQQVGVVATGNGR 311 + + T +K L + + T Sbjct: 280 TMFVSELSSTKKLTTLADAVIGSSTDGDVVAFNRMTGEKLWENHDLKYRGLTNPVTIGTY 339 Query: 312 IISLSLDGTLNFYELGHDEVLKTISGHNKGITALTV--NPLISGSYDGRIMEW 362 I DG ++ L H + + + +T LTV N L + S DG + W Sbjct: 340 IAVGDADGVVHI--LNHQGQIISRANTKGALTNLTVINNRLYAQSADGVVTVW 390 >3DWL-C nrPDB Length = 377 Score = 32.2 bits (71), Expect = 0.73, Method: Composition-based stats. Identities = 51/274 (18%), Positives = 90/274 (32%), Gaps = 38/274 (13%) Query: 339 NKGITALTVNPLISGSYDGRIMEWSSSSMHQDHSNLIVSLDNSKAQE-YSSISWDDTLKV 397 + +T N + DG W + DH ++ +D + + S D Sbjct: 24 TEFVTTTATNQVELYEQDG--NGWKHARTFSDHDKIVTCVDWAPKSNRIVTCSQDRN--- 78 Query: 398 NGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQN 457 + + +P T L++L+ N AV Sbjct: 79 ----AYVYEKRPDG------------TWKQTLVLLRLNRAATFVRWSPNEDKFAVGSGAR 122 Query: 458 YVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDL 517 ++V E +D VS LK PLR+ + P+ +AAG K + Sbjct: 123 VISVCYFEQE-------NDWWVSKHLKRPLRSTILSLDWHPNNVLLAAGCADRKAYVLSA 175 Query: 518 QSREV----KTSRWAFHT--SKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVK 571 R+V + S W + + A A + +A D+++ I Sbjct: 176 YVRDVDAKPEASVWGSRLPFNTVCAEYPSGGWVHAVGFSPSGNALAYAGHDSSVTIAYPS 235 Query: 572 RPMKIIKALNAHKDG---VNNLLWETPSTLVSSG 602 P + +AL K + +LLW S +V++G Sbjct: 236 APEQPPRALITVKLSQLPLRSLLWANESAIVAAG 269 >5UE8-A nrPDB Length = 961 Score = 31.0 bits (68), Expect = 1.6, Method: Composition-based stats. Identities = 13/87 (14%), Positives = 27/87 (31%), Gaps = 5/87 (5%) Query: 285 KCVQKWTLDKQQLGNQQVG----VVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNK 340 K V++ LD + ++ + + S D + + KTI G+ Sbjct: 146 KAVKQSVLDGTSKWSAKISITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLN 205 Query: 341 GITALTVNPLISGSYDG-RIMEWSSSS 366 + + S D ++ W Sbjct: 206 PVWEENFHFECHNSSDRIKVRVWDEDD 232 >4YHC-A nrPDB Length = 468 Score = 30.7 bits (67), Expect = 1.9, Method: Composition-based stats. Identities = 22/85 (25%), Positives = 38/85 (44%), Gaps = 2/85 (2%) Query: 263 DSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLN 322 + + FA+VG D ++ VWD+ + K L K+Q+ + G +SL TL Sbjct: 41 NYKTFASVGLDRSLVVWDLR--QWCTKLVLSKEQMPRTLKAIALDPQGNYVSLFSKDTLF 98 Query: 323 FYELGHDEVLKTISGHNKGITALTV 347 + ++ S H+K + L V Sbjct: 99 ILNVESPSLMLQHSYHSKPNSKLNV 123 >5MVH-A nrPDB Length = 431 Score = 29.9 bits (65), Expect = 3.2, Method: Composition-based stats. Identities = 28/179 (15%), Positives = 51/179 (28%), Gaps = 32/179 (17%) Query: 23 HLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLC 82 HLS+D + + Y + + L+ GD + TG VT +F P+ G Sbjct: 104 HLSFDHHGHKLNYCRSTAPY--TLELGDKEP-----MTGVDEGNVTYPEFYPLNGGD--- 153 Query: 83 SGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFG 142 + V+ N V + + + W+ L + R+ + Sbjct: 154 ------LLFVYRSGSSGRGNLVMNHYS---------VKEKKWNRVQDVLIDGEDQRNAYW 198 Query: 143 VFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTV-GDDGSVVFYQGPPFKFSASDR 200 + G H + D V +Y+ K+ R Sbjct: 199 QLYVDEQGTI------HLSWVWRETWHVETNHDLCYARSYDNGVTWYKANGKKYDLPIR 251 >3ZYZ-A nrPDB Length = 713 Score = 29.5 bits (64), Expect = 4.0, Method: Composition-based stats. Identities = 19/98 (19%), Positives = 29/98 (29%), Gaps = 2/98 (2%) Query: 132 CVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGP 191 G+D VFI+ DSG V G++ N + V S V Sbjct: 422 ASAARGKDVAIVFITADSGEGYITVEGNAGDRNNLDPWHNGNALVQAVAGANSNVIVVVH 481 Query: 192 PFK--FSASDRTHHKQGSFVRDVEFSPDSGEFVITVGS 227 + + V S +SG ++ V Sbjct: 482 SVGAIILEQILALPQVKAVVWAGLPSQESGNALVDVLW 519 >5GRS-A nrPDB Length = 396 Score = 28.7 bits (62), Expect = 6.7, Method: Composition-based stats. Identities = 19/76 (25%), Positives = 32/76 (42%), Gaps = 2/76 (2%) Query: 263 DSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLN 322 + + FA+VG D + VWD+ + K L K+Q+ + G +SL TL Sbjct: 41 NYKTFASVGLDRCLVVWDLR--QWCTKLVLSKEQMPRTLKAIALDPQGNYVSLFSKDTLF 98 Query: 323 FYELGHDEVLKTISGH 338 + ++ S H Sbjct: 99 ILNVESPSLMLQHSYH 114 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.308 0.113 0.279 Lambda K H 0.267 0.0344 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 19,603,045 Number of Sequences: 36641 Number of extensions: 711960 Number of successful extensions: 4687 Number of sequences better than 10.0: 146 Number of HSP's better than 10.0 without gapping: 149 Number of HSP's successfully gapped in prelim test: 102 Number of HSP's that attempted gapping in prelim test: 1680 Number of HSP's gapped (non-prelim): 990 length of query: 615 length of database: 10,336,785 effective HSP length: 103 effective length of query: 512 effective length of database: 6,562,762 effective search space: 3360134144 effective search space used: 3360134144 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.8 bits) S2: 61 (28.4 bits)