BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P43405 (635 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4FL3-A nrPDB 1327 0.0 2OZO-A nrPDB 695 0.0 5C26-A nrPDB 614 e-176 1A81-A nrPDB 532 e-151 1U59-A nrPDB 355 3e-98 4XZ1-A nrPDB 321 5e-88 4CSV-A nrPDB 214 6e-56 4EBW-A nrPDB 214 9e-56 2J0K-A nrPDB 214 1e-55 5GNK-A nrPDB 209 2e-54 3BBT-B nrPDB 209 3e-54 4XEY-B nrPDB 208 5e-54 3LZB-A nrPDB 208 7e-54 6NPU-A nrPDB 206 2e-53 2FO0-A nrPDB 206 2e-53 2XYN-A nrPDB 204 7e-53 4LRM-A nrPDB 202 3e-52 4H1J-A nrPDB 199 2e-51 3PP0-A nrPDB 199 4e-51 1U54-B nrPDB 196 3e-50 2PL0-A nrPDB 196 3e-50 4HZS-A nrPDB 196 4e-50 4E93-A nrPDB 195 6e-50 4P5Q-A nrPDB 190 1e-48 1JPA-A nrPDB 189 3e-48 5MJB-A nrPDB 188 6e-48 3KUL-B nrPDB 188 6e-48 3DKO-A nrPDB 188 7e-48 5AMN-A nrPDB 187 1e-47 2R2P-A nrPDB 184 9e-47 4PDO-A nrPDB 184 1e-46 1K9A-A nrPDB 184 2e-46 2Y6O-A nrPDB 183 2e-46 5L6P-A nrPDB 183 2e-46 5FM2-A nrPDB 182 3e-46 2HK5-A nrPDB 182 5e-46 3QGY-A nrPDB 181 7e-46 1BYG-A nrPDB 181 1e-45 1LUF-A nrPDB 179 3e-45 2DQ7-X nrPDB 178 5e-45 5U6B-A nrPDB 177 8e-45 4Y93-A nrPDB 177 1e-44 2H8H-A nrPDB 177 1e-44 3A4O-X nrPDB 176 4e-44 3SXS-A nrPDB 175 5e-44 5SYS-A nrPDB 175 5e-44 4XI2-A nrPDB 175 5e-44 5U6C-A nrPDB 175 6e-44 4XCU-A nrPDB 175 6e-44 1AD5-A nrPDB 175 7e-44 6F3F-A nrPDB 174 8e-44 6E4F-A nrPDB 174 9e-44 2VWV-A nrPDB 172 3e-43 3LMG-A nrPDB 172 5e-43 5WNO-A nrPDB 172 6e-43 5A46-A nrPDB 169 3e-42 2PSQ-A nrPDB 169 3e-42 3I81-A nrPDB 169 4e-42 3TT0-A nrPDB 168 5e-42 3GQL-A nrPDB 168 7e-42 4K33-A nrPDB 168 9e-42 3QUP-A nrPDB 166 2e-41 3ZZW-A nrPDB 166 2e-41 2W1I-A nrPDB 166 3e-41 4XLV-A nrPDB 166 3e-41 6DBN-A nrPDB 166 3e-41 3IO7-A nrPDB 166 4e-41 6DBM-A nrPDB 165 5e-41 3PLS-A nrPDB 164 7e-41 5EG3-A nrPDB 164 8e-41 4AT3-A nrPDB 163 2e-40 4OLI-A nrPDB 163 2e-40 4HVI-A nrPDB 163 2e-40 6FER-A nrPDB 163 2e-40 1FVR-A nrPDB 163 2e-40 3V5Q-A nrPDB 162 4e-40 5H2U-A nrPDB 162 5e-40 6GQK-A nrPDB 162 6e-40 4E20-A nrPDB 161 8e-40 5HLW-A nrPDB 160 2e-39 3ZBF-A nrPDB 159 2e-39 2OGV-A nrPDB 157 2e-38 3KRL-A nrPDB 156 2e-38 3BEA-A nrPDB 156 2e-38 3C1X-A nrPDB 155 4e-38 5KMM-A nrPDB 154 8e-38 3AOX-A nrPDB 154 1e-37 4R7H-A nrPDB 154 2e-37 3G0E-A nrPDB 153 3e-37 6FEX-A nrPDB 149 3e-36 3CJF-A nrPDB 149 3e-36 6BSD-A nrPDB 149 4e-36 4XUF-A nrPDB 149 4e-36 5X02-A nrPDB 149 5e-36 5GRN-A nrPDB 147 2e-35 4UYA-A nrPDB 129 4e-30 4UY9-A nrPDB 127 1e-29 4RT7-A nrPDB 126 3e-29 3HNG-A nrPDB 126 3e-29 3DTC-A nrPDB 125 5e-29 3VHK-A nrPDB 124 9e-29 5X5O-A nrPDB 120 1e-27 5VO2-A nrPDB 116 3e-26 3PPZ-A nrPDB 113 3e-25 4NEU-A nrPDB 105 4e-23 5USZ-A nrPDB 101 1e-21 4F0G-A nrPDB 97 2e-20 6FDY-U nrPDB 97 2e-20 5ES1-A nrPDB 95 8e-20 3OMV-A nrPDB 95 1e-19 5HI2-A nrPDB 95 1e-19 4GS6-A nrPDB 93 3e-19 2HAK-A nrPDB 92 6e-19 6J5U-C nrPDB 92 7e-19 2QNJ-A nrPDB 92 8e-19 4X3F-A nrPDB 92 9e-19 5WNL-A nrPDB 91 1e-18 4OW8-A nrPDB 91 1e-18 5KZ7-A nrPDB 91 1e-18 6C9D-A nrPDB 91 2e-18 6B2Q-A nrPDB 91 2e-18 2Z7Q-A nrPDB 91 2e-18 5C01-A nrPDB 91 2e-18 5D9K-A nrPDB 91 2e-18 4WOV-A nrPDB 91 2e-18 4YFF-A nrPDB 90 2e-18 3COM-A nrPDB 90 3e-18 5HIE-A nrPDB 90 4e-18 4L00-A nrPDB 90 4e-18 4MVF-A nrPDB 88 1e-17 4LG4-A nrPDB 87 2e-17 2YCR-A nrPDB 87 2e-17 4QMW-A nrPDB 87 2e-17 6AO5-A nrPDB 87 3e-17 4M69-B nrPDB 86 4e-17 3I6U-A nrPDB 86 6e-17 3LIJ-A nrPDB 86 6e-17 2XIK-A nrPDB 85 1e-16 5HVK-A nrPDB 85 1e-16 4BTF-A nrPDB 84 1e-16 4RA4-A nrPDB 84 1e-16 5YKS-A nrPDB 84 2e-16 5TOS-A nrPDB 84 2e-16 4TPT-A nrPDB 84 2e-16 1FOT-A nrPDB 83 4e-16 3Q5I-A nrPDB 82 6e-16 3IS5-A nrPDB 82 9e-16 3DXN-A nrPDB 82 9e-16 3T04-A nrPDB 82 9e-16 3PFQ-A nrPDB 81 1e-15 3DFA-A nrPDB 81 1e-15 2I0E-A nrPDB 81 1e-15 4WNO-A nrPDB 80 2e-15 3HZT-A nrPDB 80 2e-15 5XZW-A nrPDB 80 2e-15 3NCG-A nrPDB 80 2e-15 4FZF-B nrPDB 80 2e-15 6QAU-A nrPDB 80 2e-15 4MWI-A nrPDB 80 3e-15 6AMW-A nrPDB 80 3e-15 6CTH-A nrPDB 80 3e-15 2ABL-A nrPDB 79 5e-15 4REW-A nrPDB 79 7e-15 5JN2-A nrPDB 79 7e-15 4RED-A nrPDB 79 7e-15 3MA6-A nrPDB 79 7e-15 1S9I-A nrPDB 79 7e-15 3NIZ-A nrPDB 79 8e-15 3D2K-A nrPDB 79 9e-15 4FR4-A nrPDB 79 9e-15 2WQN-A nrPDB 78 1e-14 4CFH-A nrPDB 78 1e-14 3DAK-A nrPDB 78 1e-14 2J90-A nrPDB 78 1e-14 4L42-A nrPDB 78 1e-14 4PDS-A nrPDB 78 1e-14 3QA8-A nrPDB 77 2e-14 2XNP-A nrPDB 77 2e-14 4CFF-A nrPDB 77 3e-14 4AGU-A nrPDB 77 3e-14 5O0Y-A nrPDB 76 4e-14 5EZV-A nrPDB 76 4e-14 2YAB-A nrPDB 76 4e-14 3A8W-A nrPDB 76 4e-14 4KIK-B nrPDB 76 4e-14 2X4F-A nrPDB 76 4e-14 5FET-A nrPDB 76 5e-14 4UZD-A nrPDB 76 5e-14 2YZA-A nrPDB 75 6e-14 4M66-A nrPDB 75 7e-14 4EQM-A nrPDB 75 9e-14 4BBM-A nrPDB 75 1e-13 5XD6-A nrPDB 75 1e-13 3ORP-A nrPDB 75 1e-13 4YNZ-A nrPDB 75 1e-13 6HXF-B nrPDB 74 1e-13 4RLP-A nrPDB 74 2e-13 4JXF-A nrPDB 74 2e-13 5DYK-A nrPDB 74 3e-13 5AR8-A nrPDB 74 3e-13 5KKR-C nrPDB 73 4e-13 4AN9-A nrPDB 72 6e-13 5DBX-A nrPDB 72 7e-13 3EQC-A nrPDB 72 7e-13 5F9E-A nrPDB 72 8e-13 1ZWS-A nrPDB 72 8e-13 5LPZ-A nrPDB 72 9e-13 2A27-A nrPDB 72 1e-12 5LPV-A nrPDB 72 1e-12 6GU6-A nrPDB 71 1e-12 6BDL-A nrPDB 71 1e-12 1G3N-A nrPDB 71 2e-12 4WB7-A nrPDB 71 2e-12 3KN6-A nrPDB 71 2e-12 4AU8-A nrPDB 71 2e-12 5X3F-B nrPDB 70 2e-12 3NIE-A nrPDB 70 2e-12 5N23-A nrPDB 70 2e-12 4RGJ-A nrPDB 70 2e-12 3GUB-A nrPDB 70 2e-12 5TQX-A nrPDB 70 2e-12 3PG1-A nrPDB 70 3e-12 3LM0-A nrPDB 70 3e-12 3ALO-A nrPDB 70 3e-12 3MN3-A nrPDB 70 3e-12 5IG1-A nrPDB 70 4e-12 4D2V-A nrPDB 70 4e-12 2UV2-A nrPDB 69 4e-12 5UIU-A nrPDB 69 5e-12 5B2L-A nrPDB 69 5e-12 4KS7-A nrPDB 69 5e-12 4B8L-A nrPDB 69 6e-12 2Y4I-B nrPDB 69 6e-12 5NGU-A nrPDB 69 7e-12 2A1A-B nrPDB 69 7e-12 3H4J-B nrPDB 69 8e-12 2W4O-A nrPDB 69 8e-12 1U5R-A nrPDB 69 9e-12 6CMJ-A nrPDB 68 9e-12 3Q53-A nrPDB 68 9e-12 4KRC-A nrPDB 68 1e-11 2F57-A nrPDB 68 1e-11 1KOB-A nrPDB 68 1e-11 2BPM-A nrPDB 68 1e-11 3RP9-A nrPDB 68 1e-11 4CZT-A nrPDB 68 1e-11 3N9X-A nrPDB 68 1e-11 3HDN-A nrPDB 68 2e-11 2GCD-A nrPDB 67 2e-11 3UIU-A nrPDB 67 2e-11 5Z33-A nrPDB 67 2e-11 4CQG-A nrPDB 67 2e-11 5EFQ-A nrPDB 67 2e-11 6FD3-A nrPDB 67 2e-11 3DB8-A nrPDB 67 2e-11 3ORZ-A nrPDB 67 2e-11 4FIE-A nrPDB 67 2e-11 4JG6-A nrPDB 67 3e-11 4OTD-A nrPDB 67 3e-11 4JDH-A nrPDB 67 4e-11 5LOH-A nrPDB 66 4e-11 3ZDU-A nrPDB 66 4e-11 2JAM-A nrPDB 66 5e-11 2QKW-B nrPDB 66 5e-11 4AF3-A nrPDB 65 6e-11 4APC-A nrPDB 65 7e-11 4NIF-A nrPDB 65 7e-11 2W96-B nrPDB 65 8e-11 4NST-A nrPDB 65 8e-11 4XBR-A nrPDB 65 1e-10 4I6B-A nrPDB 65 1e-10 3GC0-A nrPDB 65 1e-10 5JZN-A nrPDB 65 1e-10 4TN6-A nrPDB 65 1e-10 2Q0N-A nrPDB 65 1e-10 3TXO-A nrPDB 65 1e-10 2JDO-A nrPDB 64 2e-10 2RIO-A nrPDB 64 2e-10 3GC9-A nrPDB 64 2e-10 4QTB-A nrPDB 64 2e-10 3MV5-A nrPDB 64 2e-10 6DTL-A nrPDB 64 2e-10 3MIA-A nrPDB 64 2e-10 3F3Z-A nrPDB 64 3e-10 2F9G-A nrPDB 63 3e-10 1UA2-A nrPDB 63 3e-10 2BDW-A nrPDB 63 3e-10 5KCV-A nrPDB 63 3e-10 1VZO-A nrPDB 63 4e-10 4FG9-A nrPDB 63 4e-10 4QNY-A nrPDB 63 4e-10 3KK8-A nrPDB 63 5e-10 2V7O-A nrPDB 62 6e-10 4IC8-A nrPDB 62 8e-10 4B6L-A nrPDB 62 8e-10 4TNB-A nrPDB 62 9e-10 3UTO-A nrPDB 62 9e-10 6CCF-A nrPDB 62 1e-09 2XS0-A nrPDB 62 1e-09 1KOA-A nrPDB 61 1e-09 4ZSG-A nrPDB 61 1e-09 4CRS-A nrPDB 61 1e-09 3KA0-A nrPDB 61 2e-09 4EUT-A nrPDB 61 2e-09 4JLC-A nrPDB 61 2e-09 4EUU-A nrPDB 61 2e-09 2OZA-A nrPDB 61 2e-09 4YZB-A nrPDB 60 2e-09 2Y7J-A nrPDB 60 2e-09 1NY3-A nrPDB 60 2e-09 4D28-A nrPDB 60 2e-09 2H34-A nrPDB 60 2e-09 5D7A-A nrPDB 60 2e-09 3FXW-A nrPDB 60 2e-09 2BUJ-A nrPDB 60 3e-09 5YV8-A nrPDB 60 3e-09 6O8B-A nrPDB 60 3e-09 6E2O-A nrPDB 60 3e-09 4IDT-A nrPDB 60 3e-09 5FG8-A nrPDB 60 3e-09 1PHK-A nrPDB 60 3e-09 1TKI-A nrPDB 60 3e-09 3VN9-A nrPDB 60 4e-09 1V0B-A nrPDB 60 4e-09 6NT9-A nrPDB 60 4e-09 5G6V-A nrPDB 60 4e-09 2HW6-A nrPDB 60 4e-09 4C0T-A nrPDB 59 5e-09 3HKO-A nrPDB 59 5e-09 4BGQ-A nrPDB 59 6e-09 2OU7-A nrPDB 59 7e-09 4H1O-A nrPDB 59 7e-09 1JNK-A nrPDB 59 8e-09 3OHT-A nrPDB 59 8e-09 3FME-A nrPDB 59 9e-09 2BRG-A nrPDB 58 1e-08 4J52-A nrPDB 58 1e-08 1CM8-A nrPDB 58 1e-08 2I6L-A nrPDB 58 1e-08 3FI2-A nrPDB 58 1e-08 3MDY-A nrPDB 58 1e-08 2VD5-A nrPDB 57 2e-08 4G3E-A nrPDB 57 2e-08 4PWN-A nrPDB 57 2e-08 2JC6-A nrPDB 57 2e-08 6BXI-A nrPDB 57 2e-08 4PL5-B nrPDB 57 2e-08 2EOB-A nrPDB 57 3e-08 4MYG-A nrPDB 57 3e-08 4EWQ-A nrPDB 57 3e-08 5AWM-A nrPDB 56 5e-08 3UIM-A nrPDB 56 5e-08 5U06-A nrPDB 56 5e-08 5UUU-A nrPDB 56 6e-08 4O2Z-A nrPDB 56 6e-08 3C51-A nrPDB 55 6e-08 6CKI-A nrPDB 55 6e-08 2VN9-A nrPDB 55 7e-08 6BFN-A nrPDB 55 8e-08 1NRV-A nrPDB 55 9e-08 4LQP-A nrPDB 55 1e-07 3E7O-A nrPDB 55 1e-07 3PVW-A nrPDB 55 1e-07 4YHJ-A nrPDB 55 1e-07 3G2F-A nrPDB 55 1e-07 5U6Y-A nrPDB 54 1e-07 3UDB-A nrPDB 54 2e-07 3UC3-A nrPDB 54 2e-07 4M7I-A nrPDB 54 2e-07 2VZ6-A nrPDB 54 2e-07 3DLS-A nrPDB 54 2e-07 3REP-A nrPDB 54 2e-07 4M4Z-A nrPDB 54 2e-07 6GVJ-A nrPDB 54 2e-07 2PLE-A nrPDB 54 2e-07 5FQD-C nrPDB 54 3e-07 2AUG-A nrPDB 54 3e-07 2WTK-C nrPDB 54 3e-07 5AIR-A nrPDB 53 3e-07 3OZ6-A nrPDB 53 3e-07 2ZMD-A nrPDB 53 4e-07 5J5T-A nrPDB 53 4e-07 6CQF-A nrPDB 53 4e-07 5Y86-A nrPDB 53 4e-07 3NYO-A nrPDB 53 4e-07 3HMP-A nrPDB 53 5e-07 6HV0-A nrPDB 52 5e-07 5L2Q-C nrPDB 52 6e-07 3SV0-A nrPDB 52 6e-07 3Q4U-A nrPDB 52 7e-07 5WAX-A nrPDB 52 7e-07 4U41-A nrPDB 52 1e-06 2EKX-A nrPDB 52 1e-06 5AP3-A nrPDB 51 1e-06 6E9W-A nrPDB 51 2e-06 4XHH-A nrPDB 51 2e-06 2QLU-A nrPDB 51 2e-06 3ZUT-A nrPDB 50 2e-06 3BHH-A nrPDB 50 2e-06 4X7Q-B nrPDB 50 3e-06 3QD2-B nrPDB 50 3e-06 3SOA-A nrPDB 50 3e-06 3TKU-A nrPDB 50 3e-06 1KA6-A nrPDB 50 4e-06 3M42-A nrPDB 50 4e-06 1M27-A nrPDB 49 5e-06 3TAC-A nrPDB 49 5e-06 3SOC-A nrPDB 49 6e-06 3MY0-A nrPDB 49 6e-06 5ZTN-A nrPDB 49 8e-06 1GRI-A nrPDB 48 1e-05 4AW2-A nrPDB 48 1e-05 5TUR-A nrPDB 48 1e-05 2HDV-A nrPDB 48 1e-05 1PY5-A nrPDB 48 1e-05 5VDK-A nrPDB 48 1e-05 3BGP-A nrPDB 48 1e-05 4RC3-A nrPDB 48 1e-05 5UNP-A nrPDB 47 2e-05 4E7W-A nrPDB 47 3e-05 5J0A-A nrPDB 47 3e-05 6ED6-A nrPDB 47 4e-05 4XHL-A nrPDB 46 4e-05 4C59-A nrPDB 46 4e-05 6FYV-A nrPDB 46 5e-05 5E8V-A nrPDB 46 6e-05 2WO6-A nrPDB 45 1e-04 2LQW-A nrPDB 45 1e-04 3E3P-A nrPDB 44 2e-04 1ZXE-A nrPDB 44 2e-04 1RPY-A nrPDB 44 2e-04 5TE0-A nrPDB 44 2e-04 5VD3-A nrPDB 44 3e-04 2CS0-A nrPDB 44 3e-04 5X8I-B nrPDB 43 4e-04 2B3O-A nrPDB 43 4e-04 3PS5-A nrPDB 43 4e-04 6CMQ-A nrPDB 43 5e-04 5M6U-B nrPDB 43 5e-04 1MIL-A nrPDB 42 6e-04 5CEK-A nrPDB 41 0.002 3RAW-A nrPDB 40 0.002 2PMN-X nrPDB 40 0.002 6DC0-A nrPDB 40 0.002 2CMW-A nrPDB 40 0.003 3CXL-A nrPDB 40 0.003 5IKW-A nrPDB 39 0.005 2C47-A nrPDB 39 0.005 4NT4-A nrPDB 39 0.007 5VC6-A nrPDB 39 0.007 2CHL-A nrPDB 38 0.011 4L68-A nrPDB 38 0.012 2KK6-A nrPDB 38 0.015 2EYZ-A nrPDB 37 0.021 1XA6-A nrPDB 37 0.021 3LLT-A nrPDB 37 0.028 5GZ9-A nrPDB 36 0.040 5CLR-A nrPDB 36 0.043 2CRH-A nrPDB 35 0.087 5GZA-A nrPDB 35 0.10 4IAN-A nrPDB 35 0.10 5UU1-A nrPDB 35 0.11 3EB0-A nrPDB 35 0.12 6EWX-A nrPDB 35 0.12 3QWY-A nrPDB 35 0.12 5OAT-A nrPDB 34 0.17 6O6Q-A nrPDB 34 0.18 5VE6-A nrPDB 34 0.19 4CRL-A nrPDB 34 0.22 6HMD-A nrPDB 33 0.30 4MD7-E nrPDB 33 0.35 2LCT-A nrPDB 33 0.52 5M07-A nrPDB 32 0.60 6C5X-D nrPDB 32 0.75 5X18-A nrPDB 32 0.86 6EII-A nrPDB 32 1.0 1WA5-C nrPDB 31 1.4 4IX6-A nrPDB 31 1.6 3LAC-A nrPDB 31 1.7 4LFI-A nrPDB 31 2.1 4WEP-A nrPDB 30 2.2 6J6I-B nrPDB 30 2.3 6C7Y-B nrPDB 30 3.8 5XVU-A nrPDB 30 3.8 5X1R-A nrPDB 30 4.3 2Y6E-A nrPDB 29 6.1 5THG-A nrPDB 29 6.6 3R2T-A nrPDB 29 8.1 2RSV-A nrPDB 28 9.2 2LAV-A nrPDB 28 9.4 >4FL3-A nrPDB Length = 635 Score = 1327 bits (3435), Expect = 0.0, Method: Compositional matrix adjust. Identities = 633/635 (99%), Positives = 635/635 (100%) Query: 1 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 60 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK Sbjct: 1 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 60 Query: 61 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF 120 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF Sbjct: 61 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF 120 Query: 121 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ 180 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ Sbjct: 121 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ 180 Query: 181 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL 240 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL Sbjct: 181 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL 240 Query: 241 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK 300 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK Sbjct: 241 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK 300 Query: 301 PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP 360 PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEV+ESP+ADPEEIRP Sbjct: 301 PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVFESPFADPEEIRP 360 Query: 361 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 420 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE Sbjct: 361 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 420 Query: 421 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM 480 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM Sbjct: 421 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM 480 Query: 481 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA Sbjct: 481 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540 Query: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE Sbjct: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600 Query: 601 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN Sbjct: 601 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 >2OZO-A nrPDB Length = 613 Score = 695 bits (1794), Expect = 0.0, Method: Compositional matrix adjust. Identities = 338/631 (53%), Positives = 448/631 (70%), Gaps = 30/631 (4%) Query: 6 MADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYT 65 M D A HLPFF+G+I+R EAE++L GM+DGL+LLRQ LGG+ LS+ H + HH+ Sbjct: 1 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP 60 Query: 66 IERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKE 125 IER+LNGTYAIAGG+ H PA+LC ++S++ DGL C L+KP NRP G++P+ G F+ L++ Sbjct: 61 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD 120 Query: 126 NLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIG 185 ++R+YV+QTW L+G+ALEQAIISQ PQ+EKLIATTAHE+MPW+H ++REE+E+ + G Sbjct: 121 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG 180 Query: 186 SKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYS 245 ++T+GKFL+R R G+YAL L++ V HY I +DK GK IPEG KFDTLWQLVE+ Sbjct: 181 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK 240 Query: 246 YKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRK 305 KADGL+ L C P LP +HP+T + Sbjct: 241 LKADGLIYCLKEACPNSSASNASG-AAAPTLP-AHPSTLT-------------------- 278 Query: 306 SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYL 365 R+ T++ + Y PE A + P+ +PMDT V+ESP++DPEE++ K+++L Sbjct: 279 ----HPQRRIDTLNSDGYTPEPARITSPDKPR--PMPMDTSVFESPFSDPEELKDKKLFL 332 Query: 366 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 425 R L + D ELG GNFG+V++G Y+M+K VA+K+LK + + A +E++ EA +M Sbjct: 333 KRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QGTEKADTEEMMREAQIMH 391 Query: 426 QLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKY 484 QLDNPYIVR+IG+C+AE+ MLVMEMA GPL+K+L R + N+ EL+HQVSMGMKY Sbjct: 392 QLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKY 451 Query: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 LEE NFVHR+LAARNVLLV +HYAKISDFGLSKAL AD++YY A++ GKWP+KWYAPECI Sbjct: 452 LEEKNFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI 511 Query: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDL 604 N+ KFSS+SDVWS+GV MWEA SYGQKPY+ MKG EV A +E+G+RM CP CP E+Y L Sbjct: 512 NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYAL 571 Query: 605 MNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 M+ CW Y E+RP F VE R+R YY + + Sbjct: 572 MSDCWIYKWEDRPDFLTVEQRMRACYYSLAS 602 >5C26-A nrPDB Length = 299 Score = 614 bits (1583), Expect = e-176, Method: Compositional matrix adjust. Identities = 293/293 (100%), Positives = 293/293 (100%) Query: 343 MDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVK 402 MDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVK Sbjct: 1 MDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVK 60 Query: 403 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQ 462 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQ Sbjct: 61 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQ 120 Query: 463 NRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRAD 522 NRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRAD Sbjct: 121 NRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRAD 180 Query: 523 ENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVT 582 ENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVT Sbjct: 181 ENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVT 240 Query: 583 AMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 AMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN Sbjct: 241 AMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 293 >1A81-A nrPDB Length = 254 Score = 532 bits (1370), Expect = e-151, Method: Compositional matrix adjust. Identities = 254/254 (100%), Positives = 254/254 (100%) Query: 9 SANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIER 68 SANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIER Sbjct: 1 SANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIER 60 Query: 69 ELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLI 128 ELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLI Sbjct: 61 ELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLI 120 Query: 129 REYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKT 188 REYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKT Sbjct: 121 REYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKT 180 Query: 189 NGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKA 248 NGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKA Sbjct: 181 NGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKA 240 Query: 249 DGLLRVLTVPCQKI 262 DGLLRVLTVPCQKI Sbjct: 241 DGLLRVLTVPCQKI 254 >1U59-A nrPDB Length = 287 Score = 355 bits (912), Expect = 3e-98, Method: Compositional matrix adjust. Identities = 169/276 (61%), Positives = 214/276 (77%), Gaps = 2/276 (0%) Query: 361 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 420 K+++L R L + D ELG GNFG+V++G Y+M+K VA+K+LK + + A +E++ E Sbjct: 2 KKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QGTEKADTEEMMRE 60 Query: 421 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVS 479 A +M QLDNPYIVR+IG+C+AE+ MLVMEMA GPL+K+L R + N+ EL+HQVS Sbjct: 61 AQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVS 120 Query: 480 MGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY 539 MGMKYLEE NFVHRDLAARNVLLV +HYAKISDFGLSKAL AD++YY A++ GKWP+KWY Sbjct: 121 MGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY 180 Query: 540 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR 599 APECIN+ KFSS+SDVWS+GV MWEA SYGQKPY+ MKG EV A +E+G+RM CP CP Sbjct: 181 APECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPP 240 Query: 600 EMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 E+Y LM+ CW Y E+RP F VE R+R YY + + Sbjct: 241 ELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLAS 276 >4XZ1-A nrPDB Length = 262 Score = 321 bits (823), Expect = 5e-88, Method: Compositional matrix adjust. Identities = 145/254 (57%), Positives = 194/254 (76%) Query: 6 MADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYT 65 M D A HLPFF+G+I+R EAE++L GM+DGL+LLRQ LGG+ LS+ H + HH+ Sbjct: 4 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP 63 Query: 66 IERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKE 125 IER+LNGTYAIAGG+ H PA+LC ++S++ DGL C L+KP NRP G++P+ G F+ L++ Sbjct: 64 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDSLRD 123 Query: 126 NLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIG 185 ++R+YV+QTW L+G+ALEQAIISQ PQ+EKLIATTAHE+MPW+H ++REE+E+ + G Sbjct: 124 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG 183 Query: 186 SKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYS 245 ++T+GKFL+R R G+YAL L++ V HY I +DK GK IPEG KFDTLWQLVE+ Sbjct: 184 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK 243 Query: 246 YKADGLLRVLTVPC 259 KADGL+ L C Sbjct: 244 LKADGLIYCLKEAC 257 Score = 59.3 bits (142), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 33/97 (34%), Positives = 52/97 (53%), Gaps = 1/97 (1%) Query: 166 MPWFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHYRIDKDKTG 224 +P+F+G ISR E+E+ + + +G FL+R + G Y L L+H+ + H+ I++ G Sbjct: 11 LPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNG 70 Query: 225 KLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQK 261 +I GK +L E YS DGL L PC + Sbjct: 71 TYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNR 107 >4CSV-A nrPDB Length = 275 Score = 214 bits (546), Expect = 6e-56, Method: Compositional matrix adjust. Identities = 115/259 (44%), Positives = 162/259 (62%), Gaps = 11/259 (4%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424 + R +TLE K LGSG FG V +G ++ + VAVK LK +E L EA +M Sbjct: 8 IPRSEITLERK-LGSGQFGEVYEGKWRNYNI--EVAVKTLKEGTMS---VEEFLQEAQIM 61 Query: 425 QQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQ--QNRHVKDKNIIELVHQVSMG 481 ++L +P +V++ G+C E + ++ E G L YL+ + V + ++++ QV+ G Sbjct: 62 KKLKHPNLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASG 121 Query: 482 MKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 541 M YLE NF+HRDLAARN L+ + K++DFGL++ + DE Y A+ K+P+KW AP Sbjct: 122 MAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDE--YTARAGAKFPIKWTAP 179 Query: 542 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREM 601 E I+Y +FS KSDVW+FG+L+WE F+YGQ PY GM GSEV +E+G RM P GCP E+ Sbjct: 180 EAISYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQGCPEEI 239 Query: 602 YDLMNLCWTYDVENRPGFA 620 Y+LM CW E RP FA Sbjct: 240 YELMLQCWNKSPEERPTFA 258 >4EBW-A nrPDB Length = 304 Score = 214 bits (545), Expect = 9e-56, Method: Compositional matrix adjust. Identities = 106/252 (42%), Positives = 156/252 (61%), Gaps = 5/252 (1%) Query: 377 LGSGNFGTVKKGYYQM-KKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 +G G FG V +G Y + VA+K KN +D +++++ L EA M+Q D+P+IV++ Sbjct: 46 IGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSD-SVREKFLQEALTMRQFDHPHIVKL 104 Query: 436 IGICEAESWMLVMEMAELGPLNKYLQQNRHVKD-KNIIELVHQVSMGMKYLEESNFVHRD 494 IG+ ++ME+ LG L +LQ ++ D ++I +Q+S + YLE FVHRD Sbjct: 105 IGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRD 164 Query: 495 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSD 554 +AARNVL+ + K+ DFGLS+ + D YYKA + GK P+KW APE IN+ +F+S SD Sbjct: 165 IAARNVLVSSNDCVKLGDFGLSRYME-DSTYYKA-SKGKLPIKWMAPESINFRRFTSASD 222 Query: 555 VWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVE 614 VW FGV MWE +G KP++G+K ++V +E GER+ P CP +Y LM CW YD Sbjct: 223 VWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPS 282 Query: 615 NRPGFAAVELRL 626 RP F ++ +L Sbjct: 283 RRPRFTELKAQL 294 >2J0K-A nrPDB Length = 656 Score = 214 bits (545), Expect = 1e-55, Method: Compositional matrix adjust. Identities = 112/285 (39%), Positives = 165/285 (57%), Gaps = 13/285 (4%) Query: 344 DTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQM-KKVVKTVAVK 402 + + Y P EI+ + + L R + G G FG V +G Y + VA+K Sbjct: 373 EEDTYTMPSTRDYEIQRERIELGRCI--------GEGQFGDVHQGIYMSPENPAMAVAIK 424 Query: 403 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQ 462 KN +D +++++ L EA M+Q D+P+IV++IG+ ++ME+ LG L +LQ Sbjct: 425 TCKNCTSD-SVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQV 483 Query: 463 NRHVKD-KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRA 521 + D ++I +Q+S + YLE FVHRD+AARNVL+ K+ DFGLS+ + Sbjct: 484 RKFSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYME- 542 Query: 522 DENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 D YYKA + GK P+KW APE IN+ +F+S SDVW FGV MWE +G KP++G+K ++V Sbjct: 543 DSTYYKA-SKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDV 601 Query: 582 TAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 626 +E GER+ P CP +Y LM CW YD RP F ++ +L Sbjct: 602 IGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQL 646 >5GNK-A nrPDB Length = 297 Score = 209 bits (533), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 108/248 (43%), Positives = 162/248 (65%), Gaps = 5/248 (2%) Query: 375 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 K LGSG FGTV KG + + +KV VA+K L+ EA P E+L EA VM +DNP++ Sbjct: 25 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATSPKANKEILDEAYVMASVDNPHV 83 Query: 433 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 491 R++GIC + L+M++ G L Y+++++ ++ + ++ Q++ GM YLE+ V Sbjct: 84 CRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLV 143 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 HRDLAARNVL+ T + KI+DFGL+K L A+E Y A+ GK P+KW A E I + ++ Sbjct: 144 HRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEG-GKVPIKWMALESILHRIYTH 202 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 611 +SDVWS+GV +WE ++G KPY G+ SE++++LEKGER+ P C ++Y +M CW Sbjct: 203 QSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMI 262 Query: 612 DVENRPGF 619 D ++RP F Sbjct: 263 DADSRPKF 270 >3BBT-B nrPDB Length = 328 Score = 209 bits (532), Expect = 3e-54, Method: Compositional matrix adjust. Identities = 107/248 (43%), Positives = 160/248 (64%), Gaps = 5/248 (2%) Query: 375 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 K LGSG FGTV KG + + + V VA+KIL NE P E + EA +M +D+P++ Sbjct: 21 KVLGSGAFGTVYKGIWVPEGETVKIPVAIKIL-NETTGPKANVEFMDEALIMASMDHPHL 79 Query: 433 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 491 VR++G+C + + LV ++ G L +Y+ +++ ++ + ++ Q++ GM YLEE V Sbjct: 80 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 139 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 HRDLAARNVL+ + ++ KI+DFGL++ L DE Y A GK P+KW A ECI+Y KF+ Sbjct: 140 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADG-GKMPIKWMALECIHYRKFTH 198 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 611 +SDVWS+GV +WE ++G KPY G+ E+ +LEKGER+ P C ++Y +M CW Sbjct: 199 QSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMI 258 Query: 612 DVENRPGF 619 D ++RP F Sbjct: 259 DADSRPKF 266 >4XEY-B nrPDB Length = 408 Score = 208 bits (530), Expect = 5e-54, Method: Compositional matrix adjust. Identities = 112/261 (42%), Positives = 163/261 (62%), Gaps = 11/261 (4%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424 ++R +T++ K LG G +G V +G + KK TVAVK LK D +E L EA VM Sbjct: 122 MERTDITMKHK-LGGGQYGEVYEGVW--KKYSLTVAVKTLKE---DTMEVEEFLKEAAVM 175 Query: 425 QQLDNPYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQ-NRH-VKDKNIIELVHQVSMG 481 +++ +P +V+++G+C E + ++ E G L YL++ NR V ++ + Q+S Sbjct: 176 KEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSA 235 Query: 482 MKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 541 M+YLE+ NF+HRDLAARN L+ H K++DFGLS+ + D Y A K+P+KW AP Sbjct: 236 MEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAP 293 Query: 542 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREM 601 E + Y KFS KSDVW+FGVL+WE +YG PY G+ S+V +LEK RM P GCP ++ Sbjct: 294 ESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV 353 Query: 602 YDLMNLCWTYDVENRPGFAAV 622 Y+LM CW ++ +RP FA + Sbjct: 354 YELMRACWQWNPSDRPSFAEI 374 Score = 79.3 bits (194), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 41/106 (38%), Positives = 63/106 (59%), Gaps = 3/106 (2%) Query: 157 LIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLH 215 + + + EK W+HG +SR +E L+ S NG FL+R +++ G ++ L +EG+V H Sbjct: 1 MASVNSLEKHSWYHGPVSRNAAE--YLLSSGINGSFLVRESESSPGQRSISLRYEGRVYH 58 Query: 216 YRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQK 261 YRI+ GKL + +F+TL +LV H+S ADGL+ L P K Sbjct: 59 YRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPK 104 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 33/112 (29%), Positives = 60/112 (53%), Gaps = 7/112 (6%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74 ++ G ++R AE YL+ G+ +G +L+R+S + G ++S+ + + +HY I +G Sbjct: 12 WYHGPVSRNAAE-YLLSSGI-NGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKL 69 Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKPF---NRPQ--GVQPKTGPFE 121 ++ + A+L H+HS +DGL+ L P N+P GV P +E Sbjct: 70 YVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWE 121 >3LZB-A nrPDB Length = 327 Score = 208 bits (529), Expect = 7e-54, Method: Compositional matrix adjust. Identities = 107/248 (43%), Positives = 161/248 (64%), Gaps = 5/248 (2%) Query: 375 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 K LGSG FGTV KG + + +KV VA+K L+ EA P E+L EA VM +DNP++ Sbjct: 21 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATSPKANKEILDEAYVMASVDNPHV 79 Query: 433 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 491 R++GIC + L+ ++ G L Y+++++ ++ + ++ Q++ GM YLE+ V Sbjct: 80 CRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLV 139 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 HRDLAARNVL+ T + KI+DFGL+K L A+E Y A+ GK P+KW A E I + ++ Sbjct: 140 HRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEG-GKVPIKWMALESILHRIYTH 198 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 611 +SDVWS+GV +WE ++G KPY G+ SE++++LEKGER+ P C ++Y +M CW Sbjct: 199 QSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMI 258 Query: 612 DVENRPGF 619 D ++RP F Sbjct: 259 DADSRPKF 266 >6NPU-A nrPDB Length = 298 Score = 206 bits (525), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 112/261 (42%), Positives = 163/261 (62%), Gaps = 11/261 (4%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424 ++R +T++ K LG G +G V +G + KK TVAVK LK D +E L EA VM Sbjct: 23 MERTDITMKHK-LGGGQYGEVYEGVW--KKYSLTVAVKTLKE---DTMEVEEFLKEAAVM 76 Query: 425 QQLDNPYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQ-NRH-VKDKNIIELVHQVSMG 481 +++ +P +V+++G+C E + ++ E G L YL++ NR V ++ + Q+S Sbjct: 77 KEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSA 136 Query: 482 MKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 541 M+YLE+ NF+HRDLAARN L+ H K++DFGLS+ + D Y A K+P+KW AP Sbjct: 137 MEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAP 194 Query: 542 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREM 601 E + Y KFS KSDVW+FGVL+WE +YG PY G+ S+V +LEK RM P GCP ++ Sbjct: 195 ESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV 254 Query: 602 YDLMNLCWTYDVENRPGFAAV 622 Y+LM CW ++ +RP FA + Sbjct: 255 YELMRACWQWNPSDRPSFAEI 275 >2FO0-A nrPDB Length = 495 Score = 206 bits (524), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 111/261 (42%), Positives = 163/261 (62%), Gaps = 11/261 (4%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424 ++R +T++ K LG G +G V +G + KK TVAVK LK D +E L EA VM Sbjct: 214 MERTDITMKHK-LGGGQYGEVYEGVW--KKYSLTVAVKTLKE---DTMEVEEFLKEAAVM 267 Query: 425 QQLDNPYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQ-NRH-VKDKNIIELVHQVSMG 481 +++ +P +V+++G+C E + ++ E G L YL++ NR V ++ + Q+S Sbjct: 268 KEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSA 327 Query: 482 MKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 541 M+YLE+ NF+HR+LAARN L+ H K++DFGLS+ + D Y A K+P+KW AP Sbjct: 328 MEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAP 385 Query: 542 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREM 601 E + Y KFS KSDVW+FGVL+WE +YG PY G+ S+V +LEK RM P GCP ++ Sbjct: 386 ESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV 445 Query: 602 YDLMNLCWTYDVENRPGFAAV 622 Y+LM CW ++ +RP FA + Sbjct: 446 YELMRACWQWNPSDRPSFAEI 466 Score = 79.0 bits (193), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 41/99 (41%), Positives = 60/99 (60%), Gaps = 3/99 (3%) Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222 EK W+HG +SR +E L+ S NG FL+R +++ G ++ L +EG+V HYRI+ Sbjct: 100 EKHSWYHGPVSRNAAE--YLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 157 Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQK 261 GKL + +F+TL +LV H+S ADGL+ L P K Sbjct: 158 DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPK 196 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 33/112 (29%), Positives = 60/112 (53%), Gaps = 7/112 (6%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74 ++ G ++R AE YL+ G+ +G +L+R+S + G ++S+ + + +HY I +G Sbjct: 104 WYHGPVSRNAAE-YLLSSGI-NGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKL 161 Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKPF---NRPQ--GVQPKTGPFE 121 ++ + A+L H+HS +DGL+ L P N+P GV P +E Sbjct: 162 YVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWE 213 >2XYN-A nrPDB Length = 292 Score = 204 bits (520), Expect = 7e-53, Method: Compositional matrix adjust. Identities = 113/271 (41%), Positives = 164/271 (60%), Gaps = 11/271 (4%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424 ++R +T++ K LG G +G V G + KK TVAVK LK + + +E L EA VM Sbjct: 29 MERTDITMKHK-LGGGQYGEVYVGVW--KKYSLTVAVKTLKEDTME---VEEFLKEAAVM 82 Query: 425 QQLDNPYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQ-NRH-VKDKNIIELVHQVSMG 481 +++ +P +V+++G+C E + +V E G L YL++ NR V ++ + Q+S Sbjct: 83 KEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSA 142 Query: 482 MKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 541 M+YLE+ NF+HRDLAARN L+ H K++DFGLS+ + D Y A K+P+KW AP Sbjct: 143 MEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAP 200 Query: 542 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREM 601 E + Y FS KSDVW+FGVL+WE +YG PY G+ S+V +LEKG RM P GCP ++ Sbjct: 201 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 260 Query: 602 YDLMNLCWTYDVENRPGFAAVELRLRNYYYD 632 Y+LM CW + +RP FA ++D Sbjct: 261 YELMRACWKWSPADRPSFAETHQAFETMFHD 291 >4LRM-A nrPDB Length = 334 Score = 202 bits (514), Expect = 3e-52, Method: Compositional matrix adjust. Identities = 107/251 (42%), Positives = 161/251 (64%), Gaps = 8/251 (3%) Query: 375 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNP-- 430 K LGSG FGTV KG + + +KV VA+K L+ EA P E+L EA VM +DNP Sbjct: 25 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATSPKANKEILDEAYVMASVDNPGN 83 Query: 431 -YIVRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEES 488 ++ R++GIC + L+ ++ G L Y+++++ ++ + ++ Q++ GM YLE+ Sbjct: 84 PHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDR 143 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 VHRDLAARNVL+ T + KI+DFGL+K L A+E Y A+ GK P+KW A E I + Sbjct: 144 RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEG-GKVPIKWMALESILHRI 202 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLC 608 ++ +SDVWS+GV +WE ++G KPY G+ SE++++LEKGER+ P C ++Y +M C Sbjct: 203 YTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKC 262 Query: 609 WTYDVENRPGF 619 W D ++RP F Sbjct: 263 WMIDADSRPKF 273 >4H1J-A nrPDB Length = 293 Score = 199 bits (507), Expect = 2e-51, Method: Compositional matrix adjust. Identities = 104/259 (40%), Positives = 158/259 (61%), Gaps = 5/259 (1%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKT-VAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 ++ LG G FG V +G Y K K VAVK K + K++ ++EA +M+ LD+P+I Sbjct: 29 NRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDN-KEKFMSEAVIMKNLDHPHI 87 Query: 433 VRMIGICEAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEESNFV 491 V++IGI E E ++ME+ G L YL++N++ +K ++ Q+ M YLE N V Sbjct: 88 VKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCV 147 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 HRD+A RN+L+ + K+ DFGLS+ + DE+YYKA + P+KW +PE IN+ +F++ Sbjct: 148 HRDIAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASV-TRLPIKWMSPESINFRRFTT 205 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 611 SDVW F V MWE S+G++P+ ++ +V +LEKG+R+ P CP +Y LM CW Y Sbjct: 206 ASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDY 265 Query: 612 DVENRPGFAAVELRLRNYY 630 D +RP F + L + Y Sbjct: 266 DPSDRPRFTELVCSLSDVY 284 >3PP0-A nrPDB Length = 338 Score = 199 bits (505), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 105/248 (42%), Positives = 153/248 (61%), Gaps = 5/248 (2%) Query: 375 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 K LGSG FGTV KG + + V VA+K+L+ E P E+L EA VM + +PY+ Sbjct: 23 KVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLR-ENTSPKANKEILDEAYVMAGVGSPYV 81 Query: 433 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 491 R++GIC + LV ++ G L ++++NR + ++++ Q++ GM YLE+ V Sbjct: 82 SRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLV 141 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 HRDLAARNVL+ + ++ KI+DFGL++ L DE Y A GK P+KW A E I +F+ Sbjct: 142 HRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHAD-GGKVPIKWMALESILRRRFTH 200 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 611 +SDVWS+GV +WE ++G KPY G+ E+ +LEKGER+ P C ++Y +M CW Sbjct: 201 QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMI 260 Query: 612 DVENRPGF 619 D E RP F Sbjct: 261 DSECRPRF 268 >1U54-B nrPDB Length = 291 Score = 196 bits (498), Expect = 3e-50, Method: Compositional matrix adjust. Identities = 102/253 (40%), Positives = 153/253 (60%), Gaps = 6/253 (2%) Query: 375 KELGSGNFGTVKKGYYQMK--KVVKTVAVKILKNEA-NDPALKDELLAEANVMQQLDNPY 431 ++LG G+FG V++G + K V +VAVK LK + + P D+ + E N M LD+ Sbjct: 24 EKLGDGSFGVVRRGEWDAPSGKTV-SVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRN 82 Query: 432 IVRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNF 490 ++R+ G+ +V E+A LG L L++++ H + QV+ GM YLE F Sbjct: 83 LIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRF 142 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 +HRDLAARN+LL T+ KI DFGL +AL ++++Y Q H K P W APE + FS Sbjct: 143 IHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFS 202 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK-GERMGCPAGCPREMYDLMNLCW 609 SD W FGV +WE F+YGQ+P+ G+ GS++ ++K GER+ P CP+++Y++M CW Sbjct: 203 HASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCW 262 Query: 610 TYDVENRPGFAAV 622 + E+RP F A+ Sbjct: 263 AHKPEDRPTFVAL 275 >2PL0-A nrPDB Length = 289 Score = 196 bits (497), Expect = 3e-50, Method: Compositional matrix adjust. Identities = 112/290 (38%), Positives = 166/290 (57%), Gaps = 17/290 (5%) Query: 343 MDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVK 402 M T+ + P+ + E P+E KL+ + LG+G FG V GYY VAVK Sbjct: 4 MQTQKPQKPWWEDEWEVPRETL---KLV----ERLGAGQFGEVWMGYYNGHT---KVAVK 53 Query: 403 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQ 462 LK + P D LAEAN+M+QL + +VR+ + E ++ E E G L +L+ Sbjct: 54 SLKQGSMSP---DAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKT 110 Query: 463 NRHVK--DKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALR 520 +K ++++ Q++ GM ++EE N++HRDL A N+L+ KI+DFGL++ + Sbjct: 111 PSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI- 169 Query: 521 ADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSE 580 ++N Y A+ K+P+KW APE INY F+ KSDVWSFG+L+ E ++G+ PY GM E Sbjct: 170 -EDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPE 228 Query: 581 VTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYY 630 V LE+G RM P CP E+Y LM LCW E+RP F + L +++ Sbjct: 229 VIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFF 278 >4HZS-A nrPDB Length = 341 Score = 196 bits (497), Expect = 4e-50, Method: Compositional matrix adjust. Identities = 102/253 (40%), Positives = 153/253 (60%), Gaps = 6/253 (2%) Query: 375 KELGSGNFGTVKKGYYQMK--KVVKTVAVKILKNEA-NDPALKDELLAEANVMQQLDNPY 431 ++LG G+FG V++G + K V +VAVK LK + + P D+ + E N M LD+ Sbjct: 18 EKLGDGSFGVVRRGEWDAPSGKTV-SVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRN 76 Query: 432 IVRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNF 490 ++R+ G+ +V E+A LG L L++++ H + QV+ GM YLE F Sbjct: 77 LIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRF 136 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 +HRDLAARN+LL T+ KI DFGL +AL ++++Y Q H K P W APE + FS Sbjct: 137 IHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFS 196 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK-GERMGCPAGCPREMYDLMNLCW 609 SD W FGV +WE F+YGQ+P+ G+ GS++ ++K GER+ P CP+++Y++M CW Sbjct: 197 HASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCW 256 Query: 610 TYDVENRPGFAAV 622 + E+RP F A+ Sbjct: 257 AHKPEDRPTFVAL 269 >4E93-A nrPDB Length = 377 Score = 195 bits (495), Expect = 6e-50, Method: Compositional matrix adjust. Identities = 103/263 (39%), Positives = 157/263 (59%), Gaps = 10/263 (3%) Query: 366 DRKLLTLED----KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEA 421 D+ +L ED +++G GNFG V G + + VAVK + E P LK + L EA Sbjct: 107 DKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTL--VAVKSCR-ETLPPDLKAKFLQEA 163 Query: 422 NVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQ-QNRHVKDKNIIELVHQVS 479 +++Q +P IVR+IG+C + + +VME+ + G +L+ + ++ K ++++V + Sbjct: 164 RILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAA 223 Query: 480 MGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY 539 GM+YLE +HRDLAARN L+ ++ KISDFG+S+ AD Y + + PVKW Sbjct: 224 AGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSRE-EADGVYAASGGLRQVPVKWT 282 Query: 540 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR 599 APE +NY ++SS+SDVWSFG+L+WE FS G PY + + +EKG R+ CP CP Sbjct: 283 APEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPD 342 Query: 600 EMYDLMNLCWTYDVENRPGFAAV 622 ++ LM CW Y+ RP F+ + Sbjct: 343 AVFRLMEQCWAYEPGQRPSFSTI 365 Score = 38.1 bits (87), Expect = 0.012, Method: Compositional matrix adjust. Identities = 28/96 (29%), Positives = 50/96 (52%), Gaps = 13/96 (13%) Query: 149 SQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLL 208 S P+++K + HE++ W+HG I R E ++++ +G FL+R Y L +L Sbjct: 1 SMIPEVQKPL----HEQL-WYHGAIPRAEVAELLV----HSGDFLVRESQGKQEYVLSVL 51 Query: 209 HEGKVLHYRIDK-DKTGKLSIPEGKKFDTLWQLVEH 243 +G H+ I D +L EG+ F ++ L++H Sbjct: 52 WDGLPRHFIIQSLDNLYRL---EGEGFPSIPLLIDH 84 >4P5Q-A nrPDB Length = 361 Score = 190 bits (483), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 101/254 (39%), Positives = 151/254 (59%), Gaps = 8/254 (3%) Query: 374 DKELGSGNFGTVKKGYYQM-KKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 DK +G+G FG V G ++ K +VA+K LK + +D L EA++M Q D+P I Sbjct: 38 DKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRD-FLGEASIMGQFDHPNI 96 Query: 433 VRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELV---HQVSMGMKYLEES 488 +R+ G+ +++ M+V E E G L+ +L+ +H +I+LV ++ GMKYL + Sbjct: 97 IRLEGVVTKSKPVMIVTEYMENGSLDSFLR--KHDAQFTVIQLVGMLRGIASGMKYLSDM 154 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 +VHRDLAARN+L+ + K+SDFGLS+ L D GK P++W +PE I Y K Sbjct: 155 GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRK 214 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLC 608 F+S SDVWS+G+++WE SYG++PY M +V +++G R+ P CP +Y LM C Sbjct: 215 FTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDC 274 Query: 609 WTYDVENRPGFAAV 622 W D NRP F + Sbjct: 275 WQKDRNNRPKFEQI 288 >1JPA-A nrPDB Length = 312 Score = 189 bits (481), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 103/285 (36%), Positives = 167/285 (58%), Gaps = 10/285 (3%) Query: 346 EVYESPYA--DPEE-IRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMK-KVVKTVAV 401 +++ P+ DP E +R +D + +E + +G+G FG V G+ ++ K VA+ Sbjct: 8 KIFIDPFTFEDPNEAVREFAKEIDISCVKIE-QVIGAGEFGEVCSGHLKLPGKREIFVAI 66 Query: 402 KILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYL 460 K LK+ + +D L+EA++M Q D+P ++ + G+ ++ M++ E E G L+ +L Sbjct: 67 KTLKSGYTEKQRRD-FLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFL 125 Query: 461 QQNR-HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL 519 +QN ++ ++ ++ GMKYL + N+VHRDLAARN+L+ + K+SDFGLS+ L Sbjct: 126 RQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFL 185 Query: 520 RADEN--YYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMK 577 D + Y + GK P++W APE I Y KF+S SDVWS+G++MWE SYG++PY M Sbjct: 186 EDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMT 245 Query: 578 GSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 +V +E+ R+ P CP ++ LM CW D +RP F + Sbjct: 246 NQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQI 290 >5MJB-A nrPDB Length = 305 Score = 188 bits (478), Expect = 6e-48, Method: Compositional matrix adjust. Identities = 105/276 (38%), Positives = 164/276 (59%), Gaps = 8/276 (2%) Query: 353 ADPEE-IRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMK-KVVKTVAVKILKNEAND 410 +DP E +R +D + +E+ +G+G FG V KG ++ K VA+K LK ++ Sbjct: 10 SDPNEAVREFAKEIDVSFVKIEEV-IGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSE 68 Query: 411 PALKDELLAEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNR-HVKD 468 +D L+EA++M Q D+ I+R+ G+ ++ M++ E E L+ +L+QN Sbjct: 69 KQRRD-FLSEASIMGQFDHRNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTV 127 Query: 469 KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADEN--YY 526 ++ ++ ++ GMKYL E N+VHRDLAARN+L+ + K+SDFGLS+ L+ D + Y Sbjct: 128 IQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTY 187 Query: 527 KAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLE 586 + GK PV+W APE I Y KF+S SDVWS+G++MWE S+G++PY M +V +E Sbjct: 188 TSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIE 247 Query: 587 KGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 + R+ P CP ++ LM CW D +RP FA + Sbjct: 248 QDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEI 283 >3KUL-B nrPDB Length = 325 Score = 188 bits (478), Expect = 6e-48, Method: Compositional matrix adjust. Identities = 103/254 (40%), Positives = 148/254 (58%), Gaps = 8/254 (3%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKT-VAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 +K +GSG+ G V G ++ VA+K LK + +D L+EA++M Q D+P I Sbjct: 54 EKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRD-FLSEASIMGQFDHPNI 112 Query: 433 VRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELV---HQVSMGMKYLEES 488 +R+ G+ M+V E E G L+ +L+ H I++LV V GM+YL + Sbjct: 113 IRLEGVVTRGRLAMIVTEYMENGSLDTFLRT--HDGQFTIMQLVGMLRGVGAGMRYLSDL 170 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 +VHRDLAARNVL+ + K+SDFGLS+ L D + T GK P++W APE I + Sbjct: 171 GYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRT 230 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLC 608 FSS SDVWSFGV+MWE +YG++PY M +V + +E+G R+ P GCP ++ LM C Sbjct: 231 FSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHALHQLMLDC 290 Query: 609 WTYDVENRPGFAAV 622 W D RP F+ + Sbjct: 291 WHKDRAQRPRFSQI 304 >3DKO-A nrPDB Length = 318 Score = 188 bits (477), Expect = 7e-48, Method: Compositional matrix adjust. Identities = 106/285 (37%), Positives = 160/285 (56%), Gaps = 12/285 (4%) Query: 343 MDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMK-KVVKTVAV 401 +D E YE P + + LD + +E + +G+G FG V G ++ K VA+ Sbjct: 21 IDPETYEDPNRAVHQFAKE---LDASCIKIE-RVIGAGEFGEVCSGRLKLPGKRDVAVAI 76 Query: 402 KILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYL 460 K LK + +D L EA++M Q D+P +V + G+ + M+V+E E G L+ +L Sbjct: 77 KTLKVGYTEKQRRD-FLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFL 135 Query: 461 QQNRHVKDKNIIELV---HQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSK 517 + +H +I+LV ++ GM+YL + +VHRDLAARN+L+ + K+SDFGLS+ Sbjct: 136 R--KHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSR 193 Query: 518 ALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMK 577 + D T GK PV+W APE I Y KF+S SDVWS+G++MWE SYG++PY M Sbjct: 194 VIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMS 253 Query: 578 GSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 +V +E+G R+ P CP ++ LM CW + RP F + Sbjct: 254 NQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQI 298 >5AMN-A nrPDB Length = 299 Score = 187 bits (475), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 106/270 (39%), Positives = 161/270 (59%), Gaps = 17/270 (6%) Query: 367 RKLLTLEDKELGSGNFGTVKKG---YYQMKKVVKTVAVKILKNEANDPALKDELLAEANV 423 RK L L K LG G FG V K + + + TVAVK+LK A+ L+D LL+E NV Sbjct: 22 RKNLVL-GKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRD-LLSEFNV 79 Query: 424 MQQLDNPYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDK----------NII 472 ++Q+++P+++++ G C + +L++E A+ G L +L+++R V ++I Sbjct: 80 LKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLI 139 Query: 473 ELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHG 532 Q+S GM+YL E VHRDLAARN+L+ KISDFGLS+ + +++Y K ++ G Sbjct: 140 SFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVK-RSQG 198 Query: 533 KWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMG 592 + PVKW A E + + ++++SDVWSFGVL+WE + G PY G+ + +L+ G RM Sbjct: 199 RIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRME 258 Query: 593 CPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 P C EMY LM CW + + RP FA + Sbjct: 259 RPDNCSEEMYRLMLQCWKQEPDKRPVFADI 288 >2R2P-A nrPDB Length = 295 Score = 184 bits (467), Expect = 9e-47, Method: Compositional matrix adjust. Identities = 98/261 (37%), Positives = 153/261 (58%), Gaps = 5/261 (1%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMK-KVVKTVAVKILKNEANDPALKDELLAEANV 423 ++ +T+E + +G+G FG V G ++ K VA+K LK + +D L EA++ Sbjct: 19 IEASCITIE-RVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRD-FLGEASI 76 Query: 424 MQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMG 481 M Q D+P I+ + G+ +++ M+V E E G L+ +L++N ++ ++ +S G Sbjct: 77 MGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAG 136 Query: 482 MKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 541 MKYL + +VHRDLAARN+L+ + K+SDFGLS+ L D GK P++W AP Sbjct: 137 MKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAP 196 Query: 542 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREM 601 E I + KF+S SDVWS+G++MWE SYG++PY M +V +E+G R+ P CP + Sbjct: 197 EAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAAL 256 Query: 602 YDLMNLCWTYDVENRPGFAAV 622 Y LM CW + +RP F + Sbjct: 257 YQLMLDCWQKERNSRPKFDEI 277 >4PDO-A nrPDB Length = 299 Score = 184 bits (466), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 102/275 (37%), Positives = 149/275 (54%), Gaps = 5/275 (1%) Query: 352 YADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTV--AVKILKNEAN 409 Y DP + K K +G+G FG V KG + K V A+K LK Sbjct: 17 YEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYT 76 Query: 410 DPALKDELLAEANVMQQLDNPYIVRMIG-ICEAESWMLVMEMAELGPLNKYL-QQNRHVK 467 + D L EA +M Q + I+R+ G I + + M++ E E G L+K+L +++ Sbjct: 77 EKQRVD-FLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFS 135 Query: 468 DKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYK 527 ++ ++ ++ GMKYL N+VHRDLAARN+L+ + K+SDFGLS+ L D Sbjct: 136 VLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATY 195 Query: 528 AQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 + GK P++W APE I+Y KF+S SDVWSFG++MWE +YG++PY + EV + Sbjct: 196 TTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAIND 255 Query: 588 GERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 G R+ P CP +Y LM CW + RP FA + Sbjct: 256 GFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADI 290 >1K9A-A nrPDB Length = 450 Score = 184 bits (466), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 108/258 (41%), Positives = 150/258 (58%), Gaps = 18/258 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 + +G G FG V G Y+ KV AVK +KN+A A LAEA+VM QL + +V+ Sbjct: 199 QTIGKGEFGDVMLGDYRGNKV----AVKCIKNDATAQAF----LAEASVMTQLRHSNLVQ 250 Query: 435 MIGICEAE--SWMLVMEMAELGPLNKYLQ-QNRHVKDKN-IIELVHQVSMGMKYLEESNF 490 ++G+ E +V E G L YL+ + R V + +++ V M+YLE +NF Sbjct: 251 LLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF 310 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 VHRDLAARNVL+ + AK+SDFGL+K + Q GK PVKW APE + KFS Sbjct: 311 VHRDLAARNVLVSEDNVAKVSDFGLTKEASS------TQDTGKLPVKWTAPEALREKKFS 364 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWT 610 +KSDVWSFG+L+WE +S+G+ PY + +V +EKG +M P GCP +YD+M CW Sbjct: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWH 424 Query: 611 YDVENRPGFAAVELRLRN 628 D RP F + +L + Sbjct: 425 LDAATRPTFLQLREQLEH 442 Score = 82.8 bits (203), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 53/111 (47%), Positives = 64/111 (57%), Gaps = 4/111 (3%) Query: 155 EKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKV 213 E + A T MPWFHGKI+RE++E+ L+ G FL+R N G Y LC+ EGKV Sbjct: 69 EGVKAGTKLSLMPWFHGKITREQAER--LLYPPETGLFLVRESTNYPGDYTLCVSCEGKV 126 Query: 214 LHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGT 264 HYRI + KLSI E F+ L QLVEHY+ ADGL L P GT Sbjct: 127 EHYRIMYHAS-KLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGT 176 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 32/94 (34%), Positives = 48/94 (51%), Gaps = 3/94 (3%) Query: 13 LPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNG 72 +P+F G ITRE+AE L GL+L+R+S NY G + L V+ K HY I + Sbjct: 80 MPWFHGKITREQAERLLYPP--ETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHAS- 136 Query: 73 TYAIAGGRTHASPADLCHYHSQESDGLVCLLKKP 106 +I + L +++ ++DGL L KP Sbjct: 137 KLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKP 170 >2Y6O-A nrPDB Length = 291 Score = 183 bits (464), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 97/261 (37%), Positives = 151/261 (57%), Gaps = 5/261 (1%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMK-KVVKTVAVKILKNEANDPALKDELLAEANV 423 +D + +E K +G G FG V G ++ K VA+K LK D +D L+EA++ Sbjct: 11 IDASCIKIE-KVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRD-FLSEASI 68 Query: 424 MQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMG 481 M Q D+P I+ + G+ + + M++ E E G L+ +L++N ++ ++ + G Sbjct: 69 MGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSG 128 Query: 482 MKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 541 MKYL + ++VHRDLAARN+L+ + K+SDFG+S+ L D GK P++W AP Sbjct: 129 MKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAP 188 Query: 542 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREM 601 E I Y KF+S SDVWS+G++MWE SYG++PY M +V +E+G R+ P CP + Sbjct: 189 EAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIAL 248 Query: 602 YDLMNLCWTYDVENRPGFAAV 622 + LM CW + +RP F + Sbjct: 249 HQLMLDCWQKERSDRPKFGQI 269 >5L6P-A nrPDB Length = 298 Score = 183 bits (464), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 103/276 (37%), Positives = 160/276 (57%), Gaps = 8/276 (2%) Query: 353 ADPEE-IRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYY-QMKKVVKTVAVKILKNEAND 410 +DP E +R +D + +E+ +G+G FG V +G Q + VA+K LK + Sbjct: 3 SDPNEAVREFAKEIDVSCVKIEEV-IGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTE 61 Query: 411 PALKDELLAEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNR-HVKD 468 +D L+EA++M Q D+P I+R+ G+ ++ M++ E E L+ +L+ N Sbjct: 62 RQRRD-FLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTV 120 Query: 469 KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRAD--ENYY 526 ++ ++ ++ GMKYL E N+VHRDLAARN+L+ + K+SDFGLS+ L D + Y Sbjct: 121 IQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTY 180 Query: 527 KAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLE 586 + GK P++W APE I Y KF+S SDVWS+G++MWE SYG++PY M +V +E Sbjct: 181 TSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVE 240 Query: 587 KGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 + R+ P CP ++ LM CW D RP F+ + Sbjct: 241 QDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQI 276 >5FM2-A nrPDB Length = 355 Score = 182 bits (463), Expect = 3e-46, Method: Compositional matrix adjust. Identities = 106/284 (37%), Positives = 161/284 (56%), Gaps = 31/284 (10%) Query: 367 RKLLTLEDKELGSGNFGTVKKG---YYQMKKVVKTVAVKILKNEANDPALKDELLAEANV 423 RK L L K LG G FG V K + + + TVAVK+LK A+ L+D LL+E NV Sbjct: 63 RKNLVL-GKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRD-LLSEFNV 120 Query: 424 MQQLDNPYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDK------------- 469 ++Q+++P+++++ G C + +L++E A+ G L +L+++R V Sbjct: 121 LKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSL 180 Query: 470 -----------NIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKA 518 ++I Q+S GM+YL E VHRDLAARN+L+ KISDFGLS+ Sbjct: 181 DHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRD 240 Query: 519 LRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKG 578 + +++Y K ++ G+ PVKW A E + + ++++SDVWSFGVL+WE + G PY G+ Sbjct: 241 VYEEDSYVK-RSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP 299 Query: 579 SEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 + +L+ G RM P C EMY LM CW + + RP FA + Sbjct: 300 ERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI 343 >2HK5-A nrPDB Length = 270 Score = 182 bits (461), Expect = 5e-46, Method: Compositional matrix adjust. Identities = 101/269 (37%), Positives = 152/269 (56%), Gaps = 15/269 (5%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEAN 422 + R+ L LE K+LG+G FG V Y K VKT+ + EA LAEAN Sbjct: 12 IPRESLKLE-KKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEA--------FLAEAN 62 Query: 423 VMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDK--NIIELVHQVSM 480 VM+ L + +V++ + E ++ E G L +L+ + K +I+ Q++ Sbjct: 63 VMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAE 122 Query: 481 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540 GM ++E+ N++HRDL A N+L+ KI+DFGL++ + ++N Y A+ K+P+KW A Sbjct: 123 GMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVI--EDNEYTAREGAKFPIKWTA 180 Query: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600 PE IN+ F+ KSDVWSFG+L+ E +YG+ PY GM EV LE+G RM P CP E Sbjct: 181 PEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEE 240 Query: 601 MYDLMNLCWTYDVENRPGFAAVELRLRNY 629 +Y++M CW E RP F ++ L ++ Sbjct: 241 LYNIMMRCWKNRPEERPTFEYIQSVLDDF 269 >3QGY-A nrPDB Length = 286 Score = 181 bits (460), Expect = 7e-46, Method: Compositional matrix adjust. Identities = 100/248 (40%), Positives = 145/248 (58%), Gaps = 10/248 (4%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +E+GSG FG V GY+ K VA+K +K + +D+ + EA VM +L +P +V+ Sbjct: 33 QEIGSGQFGLVHLGYWLNKD---KVAIKTIKEGSMS---EDDFIEEAEVMMKLSHPKLVQ 86 Query: 435 MIGIC-EAESWMLVMEMAELGPLNKYLQQNRHV-KDKNIIELVHQVSMGMKYLEESNFVH 492 + G+C E LV E E G L+ YL+ R + + ++ + V GM YLEE+ +H Sbjct: 87 LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH 146 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSK 552 RDLAARN L+ K+SDFG+++ + D+ Y + T K+PVKW +PE ++ ++SSK Sbjct: 147 RDLAARNCLVGENQVIKVSDFGMTRFVLDDQ--YTSSTGTKFPVKWASPEVFSFSRYSSK 204 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYD 612 SDVWSFGVLMWE FS G+ PY SEV + G R+ P +Y +MN CW Sbjct: 205 SDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKER 264 Query: 613 VENRPGFA 620 E+RP F+ Sbjct: 265 PEDRPAFS 272 >1BYG-A nrPDB Length = 278 Score = 181 bits (458), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 106/249 (42%), Positives = 146/249 (58%), Gaps = 18/249 (7%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 + +G G FG V G Y+ KV AVK +KN+A A LAEA+VM QL + +V+ Sbjct: 27 QTIGKGEFGDVMLGDYRGNKV----AVKCIKNDATAQAF----LAEASVMTQLRHSNLVQ 78 Query: 435 MIGICEAE--SWMLVMEMAELGPLNKYLQ-QNRHVKDKN-IIELVHQVSMGMKYLEESNF 490 ++G+ E +V E G L YL+ + R V + +++ V M+YLE +NF Sbjct: 79 LLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNF 138 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 VHRDLAARNVL+ + AK+SDFGL+K + Q GK PVKW APE + KFS Sbjct: 139 VHRDLAARNVLVSEDNVAKVSDFGLTKEASS------TQDTGKLPVKWTAPEALREKKFS 192 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWT 610 +KSDVWSFG+L+WE +S+G+ PY + +V +EKG +M P GCP +Y++M CW Sbjct: 193 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWH 252 Query: 611 YDVENRPGF 619 D RP F Sbjct: 253 LDAAMRPSF 261 >1LUF-A nrPDB Length = 343 Score = 179 bits (454), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 101/283 (35%), Positives = 151/283 (53%), Gaps = 44/283 (15%) Query: 375 KELGSGNFGTVKKGYYQMK-------KVVKTVAVKILKNEANDPALKDELLAEANVMQQL 427 +++G G FG V +Q + + VAVK+LK EA+ ++ + EA +M + Sbjct: 53 RDIGEGAFGRV----FQARAPGLLPYEPFTMVAVKMLKEEASA-DMQADFQREAALMAEF 107 Query: 428 DNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVH---------- 476 DNP IV+++G+C M L+ E G LN++L R + + L H Sbjct: 108 DNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFL---RSMSPHTVCSLSHSDLSTRARVS 164 Query: 477 -----------------QVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL 519 QV+ GM YL E FVHRDLA RN L+ KI+DFGLS+ + Sbjct: 165 SPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNI 224 Query: 520 RADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGS 579 + +YYKA + P++W PE I Y +++++SDVW++GV++WE FSYG +PY GM Sbjct: 225 YS-ADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHE 283 Query: 580 EVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 EV + G + CP CP E+Y+LM LCW+ +RP F ++ Sbjct: 284 EVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSI 326 >2DQ7-X nrPDB Length = 283 Score = 178 bits (452), Expect = 5e-45, Method: Compositional matrix adjust. Identities = 96/258 (37%), Positives = 148/258 (57%), Gaps = 10/258 (3%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K LG+G FG V G + VA+K LK P + L EA +M++L + +V+ Sbjct: 15 KRLGNGQFGEVWMGTWNGNT---KVAIKTLKPGTMSP---ESFLEEAQIMKKLKHDKLVQ 68 Query: 435 MIGICEAESWMLVMEMAELGPLNKYLQ--QNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 + + E +V E G L +L+ + R +K N++++ QV+ GM Y+E N++H Sbjct: 69 LYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIH 128 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSK 552 RDL + N+L+ KI+DFGL++ + ++N Y A+ K+P+KW APE Y +F+ K Sbjct: 129 RDLRSANILVGNGLICKIADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYGRFTIK 186 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYD 612 SDVWSFG+L+ E + G+ PY GM EV +E+G RM CP CP +++LM CW D Sbjct: 187 SDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKD 246 Query: 613 VENRPGFAAVELRLRNYY 630 E RP F ++ L +Y+ Sbjct: 247 PEERPTFEYLQSFLEDYF 264 >5U6B-A nrPDB Length = 307 Score = 177 bits (450), Expect = 8e-45, Method: Compositional matrix adjust. Identities = 102/288 (35%), Positives = 163/288 (56%), Gaps = 17/288 (5%) Query: 356 EEIRPK--EVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPAL 413 EE++ K +V +DR + L K LG G FG V +G + VAVK +K + Sbjct: 9 EELKEKLRDVMVDRHKVAL-GKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSE 67 Query: 414 KDELLAEANVMQQLDNPYIVRMIGIC----EAESW---MLVMEMAELGPLNKYLQQNR-- 464 ++ L+EA M++ D+P ++R+IG+C E ES+ ++++ + G L+ +L +R Sbjct: 68 LEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLG 127 Query: 465 ----HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALR 520 ++ + +++ + ++ GM+YL F+HRDLAARN +L ++DFGLSK + Sbjct: 128 DQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKI- 186 Query: 521 ADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSE 580 + +YY+ K PVKW A E + ++SKSDVWSFGV MWE + GQ PY G++ SE Sbjct: 187 YNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSE 246 Query: 581 VTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 + L +G R+ PA C +Y LM+ CW + ++RP F + L N Sbjct: 247 IYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLEN 294 >4Y93-A nrPDB Length = 446 Score = 177 bits (449), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 100/257 (38%), Positives = 149/257 (57%), Gaps = 11/257 (4%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424 +D K LT KELG+G FG VK G ++ + VA+K++K + +DE + EA VM Sbjct: 185 IDPKDLTFL-KELGTGQFGVVKYGKWRGQY---DVAIKMIKEGSMS---EDEFIEEAKVM 237 Query: 425 QQLDNPYIVRMIGICEAESWMLVM-EMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGM 482 L + +V++ G+C + + ++ E G L YL++ RH + + ++E+ V M Sbjct: 238 MNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAM 297 Query: 483 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 542 +YLE F+HRDLAARN L+ Q K+SDFG+++ + DE Y + T K+PVKW +PE Sbjct: 298 EYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDE--YTSSTGSKFPVKWASPE 355 Query: 543 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 602 + Y KFSSKSD+W+FGVLMWE +S G+ PY SE + +G R+ P +Y Sbjct: 356 VLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLASERVY 415 Query: 603 DLMNLCWTYDVENRPGF 619 +M CW + RP F Sbjct: 416 AIMYSCWHEKADERPTF 432 >2H8H-A nrPDB Length = 535 Score = 177 bits (449), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 98/268 (36%), Positives = 152/268 (56%), Gaps = 11/268 (4%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424 + R+ L LE K LG G FG V G + VA+K LK P + L EA VM Sbjct: 264 IPRESLRLEVK-LGQGCFGEVWMGTWNG---TTRVAIKTLKPGTMSP---EAFLQEAQVM 316 Query: 425 QQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYL--QQNRHVKDKNIIELVHQVSMGM 482 ++L + +V++ + E +V E G L +L + ++++ ++++ Q++ GM Sbjct: 317 KKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 376 Query: 483 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 542 Y+E N+VHRDL A N+L+ K++DFGL++ + ++N Y A+ K+P+KW APE Sbjct: 377 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPE 434 Query: 543 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 602 Y +F+ KSDVWSFG+L+ E + G+ PY GM EV +E+G RM CP CP ++ Sbjct: 435 AALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLH 494 Query: 603 DLMNLCWTYDVENRPGFAAVELRLRNYY 630 DLM CW + E RP F ++ L +Y+ Sbjct: 495 DLMCQCWRKEPEERPTFEYLQAFLEDYF 522 Score = 65.5 bits (158), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 42/107 (39%), Positives = 57/107 (53%), Gaps = 8/107 (7%) Query: 168 WFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCL--LHEGK---VLHYRIDKD 221 W+ GKI+R ESE+++L G FL+R + G+Y L + K V HY+I K Sbjct: 150 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 209 Query: 222 KTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPC--QKIGTQG 266 +G I +F++L QLV +YS ADGL LT C K TQG Sbjct: 210 DSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQG 256 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 53/196 (27%), Positives = 79/196 (40%), Gaps = 29/196 (14%) Query: 7 ADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSV-----AHGRKA 61 +DS ++FG ITR E+E L+ G +L+R+S G + LSV A G Sbjct: 142 SDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNV 201 Query: 62 HHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGL------VCLLKKPFNRPQGVQP 115 HY I + +G + I S L Y+S+ +DGL VC KP + Sbjct: 202 KHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDA 261 Query: 116 KTGPFEDLK------ENLIREYVKQTWNLQGQALEQAIISQKP---------QLEKLIAT 160 P E L+ + E TWN + AI + KP Q +++ Sbjct: 262 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV---AIKTLKPGTMSPEAFLQEAQVMKK 318 Query: 161 TAHEKMPWFHGKISRE 176 HEK+ + +S E Sbjct: 319 LRHEKLVQLYAVVSEE 334 >3A4O-X nrPDB Length = 286 Score = 176 bits (445), Expect = 4e-44, Method: Compositional matrix adjust. Identities = 97/261 (37%), Positives = 147/261 (56%), Gaps = 15/261 (5%) Query: 375 KELGSGNFGTVKKGYYQ--MKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 K LG+G FG V GYY K VKT+ + +A L EAN+M+ L + + Sbjct: 19 KRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQA--------FLEEANLMKTLQHDKL 70 Query: 433 VRMIGICEAESWM-LVMEMAELGPLNKYLQQNR--HVKDKNIIELVHQVSMGMKYLEESN 489 VR+ + E + ++ E G L +L+ + V +I+ Q++ GM Y+E N Sbjct: 71 VRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKN 130 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 ++HRDL A NVL+ KI+DFGL++ + ++N Y A+ K+P+KW APE IN+ F Sbjct: 131 YIHRDLRAANVLVSESLMCKIADFGLARVI--EDNEYTAREGAKFPIKWTAPEAINFGCF 188 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCW 609 + KSDVWSFG+L++E +YG+ PY G ++V L +G RM CP E+YD+M +CW Sbjct: 189 TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW 248 Query: 610 TYDVENRPGFAAVELRLRNYY 630 E RP F ++ L ++Y Sbjct: 249 KEKAEERPTFDYLQSVLDDFY 269 >3SXS-A nrPDB Length = 268 Score = 175 bits (444), Expect = 5e-44, Method: Compositional matrix adjust. Identities = 102/257 (39%), Positives = 149/257 (57%), Gaps = 11/257 (4%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424 L R+ +TL KELGSG FG VK G ++ + VAVK++K + +DE EA M Sbjct: 5 LKREEITLL-KELGSGQFGVVKLGKWKGQY---DVAVKMIKEGSMS---EDEFFQEAQTM 57 Query: 425 QQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQN-RHVKDKNIIELVHQVSMGM 482 +L +P +V+ G+C E + +V E G L YL+ + + ++ ++E+ + V GM Sbjct: 58 MKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGM 117 Query: 483 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 542 +LE F+HRDLAARN L+ K+SDFG+++ + D+ Y + K+PVKW APE Sbjct: 118 AFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQ--YVSSVGTKFPVKWSAPE 175 Query: 543 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 602 +Y+K+SSKSDVW+FG+LMWE FS G+ PY SEV + +G R+ P +Y Sbjct: 176 VFHYFKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIY 235 Query: 603 DLMNLCWTYDVENRPGF 619 +M CW E RP F Sbjct: 236 QIMYSCWHELPEKRPTF 252 >5SYS-A nrPDB Length = 286 Score = 175 bits (444), Expect = 5e-44, Method: Compositional matrix adjust. Identities = 98/268 (36%), Positives = 151/268 (56%), Gaps = 11/268 (4%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424 + R+ L LE K LG G FG G + VA+K LK P + L EA VM Sbjct: 15 IPRESLRLEVK-LGQGCFGECWMGTWNG---TTRVAIKTLKPGTMSP---EAFLQEAQVM 67 Query: 425 QQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYL--QQNRHVKDKNIIELVHQVSMGM 482 ++L + +V++ + E +V E G L +L + ++++ ++++ Q++ GM Sbjct: 68 KKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGM 127 Query: 483 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 542 Y+E N+VHRDL A N+L+ K++DFGL++ + ++N Y A+ K+P+KW APE Sbjct: 128 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPE 185 Query: 543 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 602 Y +F+ KSDVWSFG+L+ E + G+ PY GM EV +E+G RM CP CP ++ Sbjct: 186 AALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLH 245 Query: 603 DLMNLCWTYDVENRPGFAAVELRLRNYY 630 DLM CW D E RP F ++ L +Y+ Sbjct: 246 DLMCQCWRKDPEERPTFEYLQAFLEDYF 273 >4XI2-A nrPDB Length = 446 Score = 175 bits (444), Expect = 5e-44, Method: Compositional matrix adjust. Identities = 136/463 (29%), Positives = 210/463 (45%), Gaps = 92/463 (19%) Query: 159 ATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRI 218 A + E W+ ++R ++EQ++ K G F++R G Y + + + Sbjct: 59 AEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGG-FIVRDSSKAGKYTVSVFAKS------- 110 Query: 219 DKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPG 278 TG+ P+G ++ HY V + P + F P+L Sbjct: 111 ----TGE---PQG--------VIRHYV--------VCSTPQSQYYLAEKHLFSTIPELIN 147 Query: 279 SHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQR 338 H ++ G+ISR+K +P K++P ST W Sbjct: 148 YHQH--NSAGLISRLK---YPVSKQNKNAP-------STAGLG-----YGSW-------- 182 Query: 339 EALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKT 398 EI PK D L KELG+G FG VK G ++ + Sbjct: 183 ------------------EIDPK----DLTFL----KELGTGQFGVVKYGKWRGQY---D 213 Query: 399 VAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVM-EMAELGPLN 457 VA+K+++ + +DE + EA VM L + +V++ G+C + + ++ E G L Sbjct: 214 VAIKMIREGSMS---EDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLL 270 Query: 458 KYLQQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLS 516 YL++ RH + + ++E+ V M+YLE F+HRDLAARN L+ Q K+SDFGLS Sbjct: 271 NYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLS 330 Query: 517 KALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGM 576 + + DE Y + K+PV+W PE + Y KFSSKSD+W+FGVLMWE +S G+ PY Sbjct: 331 RYVLDDE--YTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERF 388 Query: 577 KGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGF 619 SE + +G R+ P +Y +M CW + RP F Sbjct: 389 TNSETAEHIAQGLRLYRPHLASERVYTIMYSCWHEKADERPSF 431 Score = 39.3 bits (90), Expect = 0.005, Method: Compositional matrix adjust. Identities = 30/117 (25%), Positives = 50/117 (42%), Gaps = 8/117 (6%) Query: 8 DSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKA------ 61 DS ++ ++TR +AE L Q G +G +++R S G + +SV Sbjct: 61 DSIEMYEWYSKHMTRSQAEQLLKQEG-KEGGFIVRDSSK-AGKYTVSVFAKSTGEPQGVI 118 Query: 62 HHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTG 118 HY + Y +A ++ +L +YH S GL+ LK P ++ P T Sbjct: 119 RHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSKQNKNAPSTA 175 >5U6C-A nrPDB Length = 315 Score = 175 bits (443), Expect = 6e-44, Method: Compositional matrix adjust. Identities = 103/290 (35%), Positives = 162/290 (55%), Gaps = 17/290 (5%) Query: 352 YADPEEIRPK--EVYLDRKLLTLEDKELGSGNFGTVKKG-YYQMKKVVKTVAVKILKNEA 408 + EE++ K +V +DR LL L K LG G FG+V +G Q VAVK +K + Sbjct: 18 FQGSEELQNKLEDVVIDRNLLIL-GKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDN 76 Query: 409 NDPALKDELLAEANVMQQLDNPYIVRMIGICEAESW------MLVMEMAELGPLNKYLQQ 462 + +E L+EA M+ +P ++R++G+C S M+++ + G L+ YL Sbjct: 77 SSQREIEEFLSEAACMKDFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLY 136 Query: 463 NR------HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLS 516 +R H+ + +++ + +++GM+YL NF+HRDLAARN +L ++DFGLS Sbjct: 137 SRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLS 196 Query: 517 KALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGM 576 K + + +YY+ K PVKW A E + ++SKSDVW+FGV MWE + G PY G+ Sbjct: 197 KKIYSG-DYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGV 255 Query: 577 KGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 626 + E+ L G R+ P C E+Y++M CW D +RP F+ + L+L Sbjct: 256 QNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQL 305 >4XCU-A nrPDB Length = 300 Score = 175 bits (443), Expect = 6e-44, Method: Compositional matrix adjust. Identities = 99/259 (38%), Positives = 149/259 (57%), Gaps = 16/259 (6%) Query: 375 KELGSGNFGTVKKG-YYQMKKV----VKTVAVKILKNEANDPALKDELLAEANVMQQLD- 428 K LG G FG V + + M TVAVK+LK+ A+D L D L++E VM+ + Sbjct: 23 KPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLAD-LVSEMEVMKLIGR 81 Query: 429 NPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKN-------IIELVHQVSM 480 + I+ ++G+C E + +++E A G L ++L+ R ++ +QV+ Sbjct: 82 HKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSCAYQVAR 141 Query: 481 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540 GM+YLE +HRDLAARNVL+ + KI+DFGL++ + +YYK ++G+ PVKW A Sbjct: 142 GMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVH-HIDYYKKTSNGRLPVKWMA 200 Query: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600 PE + ++ +SDVWSFG+L+WE F+ G PY G+ E+ ++L +G RM P CP E Sbjct: 201 PEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPE 260 Query: 601 MYDLMNLCWTYDVENRPGF 619 +Y LM CW RP F Sbjct: 261 LYGLMRECWHAAPSQRPTF 279 >1AD5-A nrPDB Length = 438 Score = 175 bits (443), Expect = 7e-44, Method: Compositional matrix adjust. Identities = 100/270 (37%), Positives = 146/270 (54%), Gaps = 25/270 (9%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEAN 422 + R+ L LE K+LG+G FG V Y K VKT+ + EA LAEAN Sbjct: 179 IPRESLKLE-KKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEA--------FLAEAN 229 Query: 423 VMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDK--NIIELVHQVSM 480 VM+ L + +V++ + E ++ E G L +L+ + K +I+ Q++ Sbjct: 230 VMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAE 289 Query: 481 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540 GM ++E+ N++HRDL A N+L+ KI+DFGL A+ K+P+KW A Sbjct: 290 GMAFIEQRNYIHRDLRAANILVSASLVCKIADFGL------------ARVGAKFPIKWTA 337 Query: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600 PE IN+ F+ KSDVWSFG+L+ E +YG+ PY GM EV LE+G RM P CP E Sbjct: 338 PEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEE 397 Query: 601 MYDLMNLCWTYDVENRPGFAAVELRLRNYY 630 +Y++M CW E RP F ++ L ++Y Sbjct: 398 LYNIMMRCWKNRPEERPTFEYIQSVLDDFY 427 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 35/98 (35%), Positives = 49/98 (50%), Gaps = 6/98 (6%) Query: 168 WFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCLL-----HEGKVLHYRIDKD 221 WF ISR+++E+ +L G F+IR + GSY+L + V HY+I Sbjct: 66 WFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTL 125 Query: 222 KTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPC 259 G I F TL +LV+HY DGL + L+VPC Sbjct: 126 DNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPC 163 Score = 49.3 bits (116), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 80/331 (24%), Positives = 129/331 (38%), Gaps = 51/331 (15%) Query: 7 ADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSV-----AHGRKA 61 DS +FF I+R++AE L+ G G +++R S G ++LSV G Sbjct: 58 VDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTV 117 Query: 62 HHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPF--NRPQGVQPKTG- 118 HY I NG + I+ T ++ +L ++ + +DGL L P ++PQ K Sbjct: 118 KHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAW 177 Query: 119 --PFEDLK--ENLIREYVKQTWNLQ-GQALEQAIISQKP---QLEKLIA------TTAHE 164 P E LK + L + W + + A+ + KP +E +A T H+ Sbjct: 178 EIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHD 237 Query: 165 KMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTG 224 K+ H +++E I +K G L + + GS + L ID Sbjct: 238 KLVKLHAVVTKEPIYIITEFMAK--GSLLDFLKSDEGS--------KQPLPKLID----F 283 Query: 225 KLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPA-- 282 I EG F + H +A +L ++ C KI G G + + + P Sbjct: 284 SAQIAEGMAFIEQRNYI-HRDLRAANILVSASLVC-KIADFGLARVGAKFPIKWTAPEAI 341 Query: 283 ----------TWSAGGIISRIKSYS-FPKPG 302 WS G ++ I +Y P PG Sbjct: 342 NFGSFTIKSDVWSFGILLMEIVTYGRIPYPG 372 >6F3F-A nrPDB Length = 455 Score = 174 bits (442), Expect = 8e-44, Method: Compositional matrix adjust. Identities = 98/268 (36%), Positives = 152/268 (56%), Gaps = 11/268 (4%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424 + R+ L LE K LG G FG V G + VA+K LK P + L EA VM Sbjct: 184 IPRESLRLEVK-LGQGCFGEVWMGTWNG---TTRVAIKTLKPGTMSP---EAFLQEAQVM 236 Query: 425 QQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYL--QQNRHVKDKNIIELVHQVSMGM 482 ++L + +V++ + E +V E G L +L + ++++ ++++ Q++ GM Sbjct: 237 KKLRHEKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGM 296 Query: 483 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 542 Y+E N+VHRDL A N+L+ K++DFGL++ + ++N Y A+ K+P+KW APE Sbjct: 297 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPE 354 Query: 543 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 602 Y +F+ KSDVWSFG+L+ E + G+ PY GM EV +E+G RM CP CP ++ Sbjct: 355 AALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLH 414 Query: 603 DLMNLCWTYDVENRPGFAAVELRLRNYY 630 DLM CW + E RP F ++ L +Y+ Sbjct: 415 DLMCQCWRKEPEERPTFEYLQAFLEDYF 442 Score = 65.1 bits (157), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 42/107 (39%), Positives = 57/107 (53%), Gaps = 8/107 (7%) Query: 168 WFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCL--LHEGK---VLHYRIDKD 221 W+ GKI+R ESE+++L G FL+R + G+Y L + K V HY+I K Sbjct: 70 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 129 Query: 222 KTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPC--QKIGTQG 266 +G I +F++L QLV +YS ADGL LT C K TQG Sbjct: 130 DSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQG 176 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 53/196 (27%), Positives = 79/196 (40%), Gaps = 29/196 (14%) Query: 7 ADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSV-----AHGRKA 61 +DS ++FG ITR E+E L+ G +L+R+S G + LSV A G Sbjct: 62 SDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNV 121 Query: 62 HHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGL------VCLLKKPFNRPQGVQP 115 HY I + +G + I S L Y+S+ +DGL VC KP + Sbjct: 122 KHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDA 181 Query: 116 KTGPFEDLK------ENLIREYVKQTWNLQGQALEQAIISQKP---------QLEKLIAT 160 P E L+ + E TWN + AI + KP Q +++ Sbjct: 182 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV---AIKTLKPGTMSPEAFLQEAQVMKK 238 Query: 161 TAHEKMPWFHGKISRE 176 HEK+ + +S E Sbjct: 239 LRHEKLVQLYAVVSEE 254 >6E4F-A nrPDB Length = 290 Score = 174 bits (442), Expect = 9e-44, Method: Compositional matrix adjust. Identities = 100/257 (38%), Positives = 147/257 (57%), Gaps = 11/257 (4%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424 +D K LT KELG+G FG VK G ++ + VA+K++K + +DE + EA VM Sbjct: 28 IDPKDLTFL-KELGTGQFGVVKYGKWRGQY---DVAIKMIKEGSMS---EDEFIEEAKVM 80 Query: 425 QQLDNPYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGM 482 L + +V++ G+C + ++ E G L YL++ RH + + ++E+ V M Sbjct: 81 MNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAM 140 Query: 483 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 542 +YLE F+HRDLAARN L+ Q K+SDFGLS+ + DE Y + K+PV+W PE Sbjct: 141 EYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDE--YTSSVGSKFPVRWSPPE 198 Query: 543 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 602 + Y KFSSKSD+W+FGVLMWE +S G+ PY SE + +G R+ P ++Y Sbjct: 199 VLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVY 258 Query: 603 DLMNLCWTYDVENRPGF 619 +M CW + RP F Sbjct: 259 TIMYSCWHEKADERPTF 275 >2VWV-A nrPDB Length = 302 Score = 172 bits (437), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 97/275 (35%), Positives = 156/275 (56%), Gaps = 8/275 (2%) Query: 354 DPEE-IRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMK-KVVKTVAVKILKNEANDP 411 DP E +R +D + +E+ +G+G FG V +G + K VA+K LK + Sbjct: 1 DPNEAVREFAKEIDVSYVKIEEV-IGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTER 59 Query: 412 ALKDELLAEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNR-HVKDK 469 + E L+EA++M Q ++P I+R+ G+ + M++ E E G L+ +L+ N Sbjct: 60 Q-RREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVI 118 Query: 470 NIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADEN--YYK 527 ++ ++ ++ GM+YL E ++VHRDLAARN+L+ + K+SDFGLS+ L + + Sbjct: 119 QLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTET 178 Query: 528 AQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 + GK P++W APE I + KF+S SD WS+G++MWE S+G++PY M +V +E+ Sbjct: 179 SSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQ 238 Query: 588 GERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 R+ P CP ++ LM CW D RP F V Sbjct: 239 DYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQV 273 >3LMG-A nrPDB Length = 344 Score = 172 bits (435), Expect = 5e-43, Method: Compositional matrix adjust. Identities = 96/254 (37%), Positives = 155/254 (61%), Gaps = 17/254 (6%) Query: 375 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDP---ALKDELLAEANVMQQLDN 429 K LGSG FGTV KG + + + + V +K++++++ A+ D +LA + LD+ Sbjct: 37 KVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLA----IGSLDH 92 Query: 430 PYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEES 488 +IVR++G+C S LV + LG L +++Q+R + + ++ Q++ GM YLEE Sbjct: 93 AHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEH 152 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADEN---YYKAQTHGKWPVKWYAPECIN 545 VHR+LAARNVLL + +++DFG++ L D+ Y +A+T P+KW A E I+ Sbjct: 153 GMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKT----PIKWMALESIH 208 Query: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLM 605 + K++ +SDVWS+GV +WE ++G +PY G++ +EV +LEKGER+ P C ++Y +M Sbjct: 209 FGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVM 268 Query: 606 NLCWTYDVENRPGF 619 CW D RP F Sbjct: 269 VKCWMIDENIRPTF 282 >5WNO-A nrPDB Length = 330 Score = 172 bits (435), Expect = 6e-43, Method: Compositional matrix adjust. Identities = 93/267 (34%), Positives = 156/267 (58%), Gaps = 9/267 (3%) Query: 368 KLLTLEDKELGSGNFGTVKKGYY---QMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424 +L T DK+LG+G FGTV G Y + K V VA+K+ + D + DE+L EA M Sbjct: 21 ELQTKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQT---DQSQTDEMLEEATNM 77 Query: 425 QQLDNPYIVRMIGICEAESWMLVMEMAE-LGPLNKYLQQNR-HVKDKNIIELVHQVSMGM 482 +L + ++++IG C + + ++ + LG L +L+ ++ ++ + + +Q++ GM Sbjct: 78 FRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGM 137 Query: 483 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 542 +YLE+ VHRDLA RNVL+ ++ +I+DFGLSK L+ D + ++ GK +KW A E Sbjct: 138 QYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKS-GKVAIKWLAIE 196 Query: 543 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 602 + + ++ SDVW+FGV WE ++GQ PY+GM + L+ G R+ P C +++Y Sbjct: 197 IFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLY 256 Query: 603 DLMNLCWTYDVENRPGFAAVELRLRNY 629 + CW D ++RPGF + R + + Sbjct: 257 QELLRCWMADPKSRPGFEILYERFKEF 283 >5A46-A nrPDB Length = 386 Score = 169 bits (429), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 108/293 (36%), Positives = 162/293 (55%), Gaps = 29/293 (9%) Query: 350 SPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTV----KKGYYQMK-KVVKTVAVKIL 404 S Y PE+ R E+ DR +L K LG G FG V G + K V VAVK+L Sbjct: 25 SEYELPEDPR-WELPRDRLVLG---KPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML 80 Query: 405 KNEANDPALKDELLAEANVMQQL-DNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQ 462 K++A + L D L++E +M+ + + I+ ++G C + + +++E A G L +YLQ Sbjct: 81 KSDATEKDLSD-LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQA 139 Query: 463 NR----------------HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQH 506 R + K+++ +QV+ GM+YL +HRDLAARNVL+ + Sbjct: 140 RRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN 199 Query: 507 YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAF 566 KI+DFGL++ + +YYK T+G+ PVKW APE + ++ +SDVWSFGVL+WE F Sbjct: 200 VMKIADFGLARDIH-HIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIF 258 Query: 567 SYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGF 619 + G PY G+ E+ +L++G RM P+ C E+Y +M CW RP F Sbjct: 259 TLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTF 311 >2PSQ-A nrPDB Length = 370 Score = 169 bits (428), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 104/276 (37%), Positives = 156/276 (56%), Gaps = 26/276 (9%) Query: 367 RKLLTLEDKELGSGNFGTV----KKGYYQMK-KVVKTVAVKILKNEANDPALKDELLAEA 421 R LTL K LG G FG V G + K K TVAVK+LK++A + L D L++E Sbjct: 80 RDKLTL-GKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSD-LVSEM 137 Query: 422 NVMQQL-DNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNR--------------- 464 +M+ + + I+ ++G C + + +++E A G L +YL+ R Sbjct: 138 EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPE 197 Query: 465 -HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADE 523 + K+++ +Q++ GM+YL +HRDLAARNVL+ + KI+DFGL++ + + Sbjct: 198 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDIN-NI 256 Query: 524 NYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTA 583 +YYK T+G+ PVKW APE + ++ +SDVWSFGVLMWE F+ G PY G+ E+ Sbjct: 257 DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFK 316 Query: 584 MLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGF 619 +L++G RM PA C E+Y +M CW RP F Sbjct: 317 LLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTF 352 >3I81-A nrPDB Length = 315 Score = 169 bits (428), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 94/279 (33%), Positives = 160/279 (57%), Gaps = 21/279 (7%) Query: 360 PKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKT-----VAVKILKNEANDPALK 414 P E + R+ +T+ +ELG G+FG V +G K VVK VA+K + NEA + Sbjct: 10 PDEWEVAREKITM-SRELGQGSFGMVYEGV--AKGVVKDEPETRVAIKTV-NEAASMRER 65 Query: 415 DELLAEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDKN--- 470 E L EA+VM++ + ++VR++G+ + + +++ME+ G L YL+ R + N Sbjct: 66 IEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVL 125 Query: 471 -------IIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADE 523 +I++ +++ GM YL + FVHRDLAARN ++ KI DFG+++ + + Sbjct: 126 APPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY-ET 184 Query: 524 NYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTA 583 +YY+ G PV+W +PE + F++ SDVWSFGV++WE + ++PY+G+ +V Sbjct: 185 DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLR 244 Query: 584 MLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 + +G + P CP +++LM +CW Y+ + RP F + Sbjct: 245 FVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI 283 >3TT0-A nrPDB Length = 382 Score = 168 bits (426), Expect = 5e-42, Method: Compositional matrix adjust. Identities = 108/293 (36%), Positives = 162/293 (55%), Gaps = 29/293 (9%) Query: 350 SPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTV----KKGYYQMK-KVVKTVAVKIL 404 S Y PE+ R E+ DR +L K LG G FG V G + K V VAVK+L Sbjct: 54 SEYELPEDPR-WELPRDRLVL---GKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKML 109 Query: 405 KNEANDPALKDELLAEANVMQQL-DNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQ 462 K++A + L D L++E +M+ + + I+ ++G C + + +++E A G L +YLQ Sbjct: 110 KSDATEKDLSD-LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQA 168 Query: 463 NR----------------HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQH 506 R + K+++ +QV+ GM+YL +HRDLAARNVL+ + Sbjct: 169 RRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN 228 Query: 507 YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAF 566 KI+DFGL++ + +YYK T+G+ PVKW APE + ++ +SDVWSFGVL+WE F Sbjct: 229 VMKIADFGLARDIH-HIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIF 287 Query: 567 SYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGF 619 + G PY G+ E+ +L++G RM P+ C E+Y +M CW RP F Sbjct: 288 TLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTF 340 >3GQL-A nrPDB Length = 326 Score = 168 bits (425), Expect = 7e-42, Method: Compositional matrix adjust. Identities = 108/293 (36%), Positives = 162/293 (55%), Gaps = 29/293 (9%) Query: 350 SPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTV----KKGYYQMK-KVVKTVAVKIL 404 S Y PE+ R E+ DR +L K LG G FG V G + K V VAVK+L Sbjct: 13 SEYELPEDPR-WELPRDRLVLG---KPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKML 68 Query: 405 KNEANDPALKDELLAEANVMQQL-DNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQ 462 K++A + L D L++E +M+ + + I+ ++G C + + +++E A G L +YLQ Sbjct: 69 KSDATEKDLSD-LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQA 127 Query: 463 NR----------------HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQH 506 R + K+++ +QV+ GM+YL +HRDLAARNVL+ + Sbjct: 128 RRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN 187 Query: 507 YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAF 566 KI+DFGL++ + +YYK T+G+ PVKW APE + ++ +SDVWSFGVL+WE F Sbjct: 188 VMKIADFGLARDIH-HIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIF 246 Query: 567 SYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGF 619 + G PY G+ E+ +L++G RM P+ C E+Y +M CW RP F Sbjct: 247 TLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTF 299 >4K33-A nrPDB Length = 325 Score = 168 bits (425), Expect = 9e-42, Method: Compositional matrix adjust. Identities = 103/278 (37%), Positives = 153/278 (55%), Gaps = 26/278 (9%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGY---YQMKKVVK--TVAVKILKNEANDPALKDELLA 419 L R LTL K LG G FG V + K TVAVK+LK++A D L D L++ Sbjct: 33 LSRARLTL-GKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSD-LVS 90 Query: 420 EANVMQQL-DNPYIVRMIGICEAESWMLVM-EMAELGPLNKYLQQNR------------- 464 E +M+ + + I+ ++G C + V+ E A G L ++L+ R Sbjct: 91 EMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKP 150 Query: 465 ---HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRA 521 + K+++ +QV+ GM+YL +HRDLAARNVL+ + KI+DFGL++ + Sbjct: 151 PEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVH- 209 Query: 522 DENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 + +YYK T+G+ PVKW APE + ++ +SDVWSFGVL+WE F+ G PY G+ E+ Sbjct: 210 NLDYYKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEEL 269 Query: 582 TAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGF 619 +L++G RM PA C ++Y +M CW RP F Sbjct: 270 FKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTF 307 >3QUP-A nrPDB Length = 323 Score = 166 bits (421), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 92/271 (33%), Positives = 151/271 (55%), Gaps = 21/271 (7%) Query: 375 KELGSGNFGTVKKGYYQMKK----VVKTVAVKILKNEANDPALKDELLAEANVMQQLDNP 430 + LG G FG+V++ Q+K+ VK VAVK+LK + + +E L EA M++ D+P Sbjct: 29 RMLGKGEFGSVREA--QLKQEDGSFVK-VAVKMLKADIIASSDIEEFLREAACMKEFDHP 85 Query: 431 YIVRMIGICEAESW-------MLVMEMAELGPLNKYLQQNR------HVKDKNIIELVHQ 477 ++ +++G+ M+++ + G L+ +L +R ++ + ++ + Sbjct: 86 HVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFMVD 145 Query: 478 VSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVK 537 ++ GM+YL NF+HRDLAARN +L ++DFGLS+ + + +YY+ K PVK Sbjct: 146 IACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSG-DYYRQGCASKLPVK 204 Query: 538 WYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGC 597 W A E + ++ SDVW+FGV MWE + GQ PY G++ +E+ L G R+ P C Sbjct: 205 WLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPEC 264 Query: 598 PREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 E+YDLM CW+ D + RP F + + L N Sbjct: 265 MEEVYDLMYQCWSADPKQRPSFTCLRMELEN 295 >3ZZW-A nrPDB Length = 289 Score = 166 bits (421), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 97/275 (35%), Positives = 148/275 (53%), Gaps = 22/275 (8%) Query: 375 KELGSGNFGTVKKGYY---QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPY 431 +ELG FG V KG+ + + VA+K LK++A P L++E EA + +L +P Sbjct: 15 EELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGP-LREEFRHEAMLRARLQHPN 73 Query: 432 IVRMIGICEAESWM-LVMEMAELGPLNKYL------------QQNRHVKDK----NIIEL 474 +V ++G+ + + ++ G L+++L +R VK + + L Sbjct: 74 VVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHL 133 Query: 475 VHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKW 534 V Q++ GM+YL + VH+DLA RNVL+ + KISD GL + + A +YYK + Sbjct: 134 VAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYA-ADYYKLLGNSLL 192 Query: 535 PVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP 594 P++W APE I Y KFS SD+WS+GV++WE FSYG +PY G +V M+ + + CP Sbjct: 193 PIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCP 252 Query: 595 AGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNY 629 CP +Y LM CW RP F + RLR + Sbjct: 253 DDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAW 287 >2W1I-A nrPDB Length = 326 Score = 166 bits (420), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 96/273 (35%), Positives = 152/273 (55%), Gaps = 23/273 (8%) Query: 375 KELGSGNFGTVKKGYYQ--MKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 ++LG GNFG+V+ Y + VAVK L++ + + L+D E +++ L + I Sbjct: 47 QQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQH-STEEHLRD-FEREIEILKSLQHDNI 104 Query: 433 VRMIGICEA---ESWMLVMEMAELGPLNKYLQQNRHVKDK-NIIELVHQVSMGMKYLEES 488 V+ G+C + + L+ME G L YLQ+++ D +++ Q+ GM+YL Sbjct: 105 VKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK 164 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 ++HRDLA RN+L+ ++ KI DFGL+K L D+ YYK + G+ P+ WYAPE + K Sbjct: 165 RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESK 224 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKP------YRGMKGSE---------VTAMLEKGERMGC 593 FS SDVWSFGV+++E F+Y +K + M G++ + +L+ R+ Sbjct: 225 FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPR 284 Query: 594 PAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 626 P GCP E+Y +M CW +V RP F + LR+ Sbjct: 285 PDGCPDEIYMIMTECWNNNVNQRPSFRDLALRV 317 >4XLV-A nrPDB Length = 328 Score = 166 bits (420), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 96/293 (32%), Positives = 158/293 (53%), Gaps = 27/293 (9%) Query: 352 YADPEEIRPKEVYL------DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVK-----TVA 400 Y ++ P VY+ R+ +TL +ELG G+FG V +G + ++K VA Sbjct: 17 YLSASDVFPSSVYVPDEWEVSREKITLL-RELGQGSFGMVYEG--NARDIIKGEAETRVA 73 Query: 401 VKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKY 459 VK + NE+ + E L EA+VM+ ++VR++G+ + + ++VME+ G L Y Sbjct: 74 VKTV-NESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSY 132 Query: 460 LQQNRHVKDKN----------IIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAK 509 L+ R + N +I++ +++ GM YL FVHRDLAARN ++ K Sbjct: 133 LRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVK 192 Query: 510 ISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYG 569 I DFG+++ + + +YY+ G PV+W APE + F++ SD+WSFGV++WE S Sbjct: 193 IGDFGMTRDIY-ETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLA 251 Query: 570 QKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 ++PY+G+ +V + G + P CP + DLM +CW ++ RP F + Sbjct: 252 EQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEI 304 >6DBN-A nrPDB Length = 316 Score = 166 bits (420), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 99/265 (37%), Positives = 141/265 (53%), Gaps = 21/265 (7%) Query: 375 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 ++LG G+FG V+ Y + + VAVK LK E+ + D L E +++ L + I Sbjct: 41 RDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIAD-LKKEIEILRNLYHENI 99 Query: 433 VRMIGICEAES---WMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEES 488 V+ GIC + L+ME G L +YL +N++ + K ++ Q+ GM YL Sbjct: 100 VKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSR 159 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 +VHRDLAARNVL+ ++H KI DFGL+KA+ D+ YY + PV WYAPEC+ K Sbjct: 160 QYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSK 219 Query: 549 FSSKSDVWSFGVLMWEAFSYGQK-------------PYRG-MKGSEVTAMLEKGERMGCP 594 F SDVWSFGV + E +Y P G M + + L++G+R+ CP Sbjct: 220 FYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCP 279 Query: 595 AGCPREMYDLMNLCWTYDVENRPGF 619 CP E+Y LM CW + NR F Sbjct: 280 PNCPDEVYQLMRKCWEFQPSNRTSF 304 >3IO7-A nrPDB Length = 313 Score = 166 bits (419), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 96/273 (35%), Positives = 152/273 (55%), Gaps = 23/273 (8%) Query: 375 KELGSGNFGTVKKGYYQ--MKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 ++LG GNFG+V+ Y + VAVK L++ + + L+D E +++ L + I Sbjct: 34 QQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQH-STEEHLRD-FEREIEILKSLQHDNI 91 Query: 433 VRMIGICEA---ESWMLVMEMAELGPLNKYLQQNRHVKDK-NIIELVHQVSMGMKYLEES 488 V+ G+C + + L+ME G L YLQ+++ D +++ Q+ GM+YL Sbjct: 92 VKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK 151 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 ++HRDLA RN+L+ ++ KI DFGL+K L D+ YYK + G+ P+ WYAPE + K Sbjct: 152 RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESK 211 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKP------YRGMKGSE---------VTAMLEKGERMGC 593 FS SDVWSFGV+++E F+Y +K + M G++ + +L+ R+ Sbjct: 212 FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPR 271 Query: 594 PAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 626 P GCP E+Y +M CW +V RP F + LR+ Sbjct: 272 PDGCPDEIYMIMTECWNNNVNQRPSFRDLALRV 304 >6DBM-A nrPDB Length = 318 Score = 165 bits (418), Expect = 5e-41, Method: Compositional matrix adjust. Identities = 100/264 (37%), Positives = 138/264 (52%), Gaps = 21/264 (7%) Query: 375 KELGSGNFGTVKKGYYQMKK--VVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 ++LG G+FG V Y + VAVK LK +A P + E ++++ L + +I Sbjct: 37 RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAG-PQHRSGWKQEIDILRTLYHEHI 95 Query: 433 VRMIGICE---AESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 ++ G CE A S LVME LG L YL ++ + ++ Q+ GM YL + Sbjct: 96 IKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHS-IGLAQLLLFAQQICEGMAYLHSQH 154 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 ++HRDLAARNVLL KI DFGL+KA+ YY+ + G PV WYAPEC+ YKF Sbjct: 155 YIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKF 214 Query: 550 SSKSDVWSFGVLMWEAFSY---GQKPYRG-----------MKGSEVTAMLEKGERMGCPA 595 SDVWSFGV ++E ++ Q P M +T +LE+GER+ P Sbjct: 215 YYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPD 274 Query: 596 GCPREMYDLMNLCWTYDVENRPGF 619 CP E+Y LM CW + RP F Sbjct: 275 KCPAEVYHLMKNCWETEASFRPTF 298 >3PLS-A nrPDB Length = 298 Score = 164 bits (416), Expect = 7e-41, Method: Compositional matrix adjust. Identities = 99/265 (37%), Positives = 149/265 (56%), Gaps = 16/265 (6%) Query: 368 KLLTLEDKELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 425 +++T D+ +G G+FG V G Y Q + ++ A+K L + + + L E +M+ Sbjct: 20 RVVTHSDRVIGKGHFGVVYHGEYIDQAQNRIQC-AIKSL-SRITEMQQVEAFLREGLLMR 77 Query: 426 QLDNPYIVRMIGIC---EAESWMLVMEMAELGPLNKYL---QQNRHVKDKNIIELVHQVS 479 L++P ++ +IGI E +L+ M G L +++ Q+N VKD +I QV+ Sbjct: 78 GLNHPNVLALIGIMLPPEGLPHVLLPYMCH-GDLLQFIRSPQRNPTVKD--LISFGLQVA 134 Query: 480 MGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTH--GKWPVK 537 GM+YL E FVHRDLAARN +L K++DFGL++ + D YY Q H + PVK Sbjct: 135 RGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDI-LDREYYSVQQHRHARLPVK 193 Query: 538 WYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGC 597 W A E + Y+F++KSDVWSFGVL+WE + G PYR + ++T L +G R+ P C Sbjct: 194 WTALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYC 253 Query: 598 PREMYDLMNLCWTYDVENRPGFAAV 622 P +Y +M CW D RP F + Sbjct: 254 PDSLYQVMQQCWEADPAVRPTFRVL 278 >5EG3-A nrPDB Length = 334 Score = 164 bits (416), Expect = 8e-41, Method: Compositional matrix adjust. Identities = 101/276 (36%), Positives = 155/276 (56%), Gaps = 26/276 (9%) Query: 367 RKLLTLEDKELGSGNFGTV----KKGYYQMK-KVVKTVAVKILKNEANDPALKDELLAEA 421 R LTL K LG G FG V G + K K TVAVK+LK++A + L D L++E Sbjct: 34 RDKLTL-GKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSD-LVSEM 91 Query: 422 NVMQQL-DNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNR--------------- 464 +M+ + + I+ ++G C + + +++ A G L +YL+ R Sbjct: 92 EMMKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPE 151 Query: 465 -HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADE 523 + K+++ +Q++ GM+YL +HRDLAARNVL+ + KI+DFGL++ + + Sbjct: 152 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDIN-NI 210 Query: 524 NYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTA 583 +++K T+G+ PVKW APE + ++ +SDVWSFGVLMWE F+ G PY G+ E+ Sbjct: 211 DFFKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFK 270 Query: 584 MLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGF 619 +L++G RM PA C E+Y +M CW RP F Sbjct: 271 LLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTF 306 >4AT3-A nrPDB Length = 299 Score = 163 bits (413), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 95/271 (35%), Positives = 149/271 (54%), Gaps = 20/271 (7%) Query: 375 KELGSGNFGTV--KKGYYQMKKVVKT-VAVKILKNEANDPALKDELLAEANVMQQLDNPY 431 +ELG G FG V + Y + K VAVK LK +A+D A KD EA ++ L + + Sbjct: 19 RELGEGAFGKVFLAECYNLCPEQDKILVAVKTLK-DASDNARKD-FHREAELLTNLQHEH 76 Query: 432 IVRMIGIC-EAESWMLVMEMAELGPLNKYLQQN-------------RHVKDKNIIELVHQ 477 IV+ G+C E + ++V E + G LNK+L+ + + ++ + Q Sbjct: 77 IVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQ 136 Query: 478 VSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVK 537 ++ GM YL +FVHRDLA RN L+ KI DFG+S+ + + + YY+ H P++ Sbjct: 137 IAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTD-YYRVGGHTMLPIR 195 Query: 538 WYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGC 597 W PE I Y KF+++SDVWS GV++WE F+YG++P+ + +EV + +G + P C Sbjct: 196 WMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTC 255 Query: 598 PREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 P+E+Y+LM CW + R + L+N Sbjct: 256 PQEVYELMLGCWQREPHMRKNIKGIHTLLQN 286 >4OLI-A nrPDB Length = 645 Score = 163 bits (413), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 105/290 (36%), Positives = 147/290 (50%), Gaps = 29/290 (10%) Query: 349 ESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKK--VVKTVAVKILKN 406 +SP +DP V+ R L + D LG G+FG V Y + VAVK LK Sbjct: 341 DSPASDPT------VFHKRYLKKIRD--LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKA 392 Query: 407 EANDPALKDELLAEANVMQQLDNPYIVRMIGICEAE---SWMLVMEMAELGPLNKYLQQN 463 + P + E ++++ L + +I++ G CE + S LVME LG L YL ++ Sbjct: 393 DCG-PQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRH 451 Query: 464 RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADE 523 + ++ Q+ GM YL +++HR+LAARNVLL KI DFGL+KA+ Sbjct: 452 S-IGLAQLLLFAQQICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGH 510 Query: 524 NYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSY---GQKPYRG----- 575 YY+ + G PV WYAPEC+ YKF SDVWSFGV ++E ++ Q P Sbjct: 511 EYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELI 570 Query: 576 ------MKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGF 619 M +T +LE+GER+ P CP E+Y LM CW + RP F Sbjct: 571 GIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTF 620 Score = 89.0 bits (219), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 66/236 (27%), Positives = 111/236 (47%), Gaps = 24/236 (10%) Query: 399 VAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLN 457 V +K+L +D AL A++M Q+ + ++ + G+C ++V E E GPL+ Sbjct: 97 VVLKVLDPSHHDIALA--FYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLD 154 Query: 458 KYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV-------TQHYAK 509 +L++ R HV + + Q++ + YLE N VH ++ RN+LL T + K Sbjct: 155 VWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIK 214 Query: 510 ISDFGLS-KALRADENYYKAQTHGKWPVKWYAPECI--NYYKFSSKSDVWSFGVLMWEAF 566 +SD G+ AL +E + + W APEC+ S+ D W FG + E Sbjct: 215 LSDPGVGLGALSREERVER--------IPWLAPECLPGGANSLSTAMDKWGFGATLLEIC 266 Query: 567 SYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 G+ P + SE ++ R+ P+ CP ++ L + C TY+ RP F + Sbjct: 267 FDGEAPLQSRSPSEKEHFYQRQHRLPEPS-CP-QLATLTSQCLTYEPTQRPSFRTI 320 >4HVI-A nrPDB Length = 314 Score = 163 bits (413), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 101/267 (37%), Positives = 154/267 (57%), Gaps = 22/267 (8%) Query: 376 ELGSGNFGTVKKGYYQM--KKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 +LG GNFG+V+ Y VAVK L++ P + + E +++ L + +IV Sbjct: 17 QLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSG--PDQQRDFQREIQILKALHSDFIV 74 Query: 434 RMIGICEA---ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVH-QVSMGMKYLEESN 489 + G+ +S LVME G L +LQ++R D + + L Q+ GM+YL Sbjct: 75 KYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRR 134 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 VHRDLAARN+L+ ++ + KI+DFGL+K L D++YY + G+ P+ WYAPE ++ F Sbjct: 135 CVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIF 194 Query: 550 SSKSDVWSFGVLMWEAFSYGQKP------YRGMKGSE--VTAM------LEKGERMGCPA 595 S +SDVWSFGV+++E F+Y K + M GSE V A+ LE+G+R+ P Sbjct: 195 SRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEGQRLPAPP 254 Query: 596 GCPREMYDLMNLCWTYDVENRPGFAAV 622 CP E+++LM LCW ++RP F+A+ Sbjct: 255 ACPAEVHELMKLCWAPSPQDRPSFSAL 281 >6FER-A nrPDB Length = 309 Score = 163 bits (413), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 101/293 (34%), Positives = 157/293 (53%), Gaps = 36/293 (12%) Query: 367 RKLLTLEDKELGSGNFGTVKKGYYQMKKVVKT--------------VAVKILKNEANDPA 412 RKLLT ++K LG G FG V + + K VAVK+L+ +AN A Sbjct: 8 RKLLTFKEK-LGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNA 66 Query: 413 LKDELLAEANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQN-------- 463 +++ L E +M +L +P I+ ++ +C + + ++ E E G LN++L ++ Sbjct: 67 -RNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSS 125 Query: 464 --RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRA 521 R V N+ + Q++ GMKYL NFVHRDLA RN L+ + KI+DFG+S+ L + Sbjct: 126 DVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYS 185 Query: 522 DENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQ-KPYRGMKGSE 580 + YY+ Q P++W + E I KF++ SDVW+FGV +WE F++ Q +PY + + Sbjct: 186 GD-YYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQ 244 Query: 581 VTA-----MLEKGER--MGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 626 V ++G + + PA CP +Y LM CW D +NRP F + L L Sbjct: 245 VIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLL 297 >1FVR-A nrPDB Length = 327 Score = 163 bits (413), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 97/268 (36%), Positives = 144/268 (53%), Gaps = 23/268 (8%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL-DNPYIVRM 435 +G GNFG V K + + A+K +K A+ +D E V+ +L +P I+ + Sbjct: 33 IGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRD-FAGELEVLCKLGHHPNIINL 91 Query: 436 IGICEAESWM-LVMEMAELGPLNKYLQQNR----------------HVKDKNIIELVHQV 478 +G CE ++ L +E A G L +L+++R + + ++ V Sbjct: 92 LGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADV 151 Query: 479 SMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKW 538 + GM YL + F+HRDLAARN+L+ + AKI+DFGLS R E Y K +T G+ PV+W Sbjct: 152 ARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLS---RGQEVYVK-KTMGRLPVRW 207 Query: 539 YAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCP 598 A E +NY +++ SDVWS+GVL+WE S G PY GM +E+ L +G R+ P C Sbjct: 208 MAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCD 267 Query: 599 REMYDLMNLCWTYDVENRPGFAAVELRL 626 E+YDLM CW RP FA + + L Sbjct: 268 DEVYDLMRQCWREKPYERPSFAQILVSL 295 >3V5Q-A nrPDB Length = 297 Score = 162 bits (410), Expect = 4e-40, Method: Compositional matrix adjust. Identities = 96/275 (34%), Positives = 153/275 (55%), Gaps = 28/275 (10%) Query: 364 YLDRKLLTLEDKELGSGNFGTVKKG-YYQMK--KVVKTVAVKILKNEANDPAL--KDELL 418 ++ R+ + L+ +ELG G FG V Y + K VAVK LK DP L + + Sbjct: 11 HIKRRDIVLK-RELGEGAFGKVFLAECYNLSPTKDKMLVAVKALK----DPTLAARKDFQ 65 Query: 419 AEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQ------------QNRH 465 EA ++ L + +IV+ G+C + + ++V E + G LNK+L+ Q R Sbjct: 66 REAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQ 125 Query: 466 VKDK----NIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRA 521 K + ++ + Q++ GM YL +FVHRDLA RN L+ KI DFG+S+ + + Sbjct: 126 AKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYS 185 Query: 522 DENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 +YY+ H P++W PE I Y KF+++SDVWSFGV++WE F+YG++P+ + +EV Sbjct: 186 -TDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEV 244 Query: 582 TAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENR 616 + +G + P CP+E+YD+M CW + + R Sbjct: 245 IECITQGRVLERPRVCPKEVYDVMLGCWQREPQQR 279 >5H2U-A nrPDB Length = 267 Score = 162 bits (410), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 92/259 (35%), Positives = 150/259 (57%), Gaps = 13/259 (5%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELL-AEANVMQQLDNPYIV 433 ++LGSG FG V +G ++ + VA+K++ + D L ++L +E M++L + +I+ Sbjct: 12 RKLGSGYFGEVFEGLWKDRV---QVAIKVI---SRDNLLHQQMLQSEIQAMKKLRHKHIL 65 Query: 434 RMIGICEA-ESWMLVMEMAELGPLNKYLQQN--RHVKDKNIIELVHQVSMGMKYLEESNF 490 + + + ++ E+ G L + L+ + + + ++++ QV+ GM YLE N+ Sbjct: 66 ALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNY 125 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 +HRDLAARN+L+ K+ DFGL++ ++ E+ Y + H P KW APE ++ +S Sbjct: 126 IHRDLAARNILVGENTLCKVGDFGLARLIK--EDVYLSHDHNI-PYKWTAPEALSRGHYS 182 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWT 610 +KSDVWSFG+L+ E FS GQ PY GM E ++ G RM CP CP ++ LM CW Sbjct: 183 TKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWC 242 Query: 611 YDVENRPGFAAVELRLRNY 629 D E RP F A+ RL ++ Sbjct: 243 RDPEQRPTFKALRERLSSF 261 >6GQK-A nrPDB Length = 328 Score = 162 bits (409), Expect = 6e-40, Method: Compositional matrix adjust. Identities = 100/270 (37%), Positives = 145/270 (53%), Gaps = 24/270 (8%) Query: 375 KELGSGNFGTVKKGYYQ---MKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDN-P 430 K LG+G FG V + Q TVAVK+LK A+ ++ L++E V+ L N Sbjct: 47 KTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTE-REALMSELKVLSYLGNHE 105 Query: 431 YIVRMIGICEAESWMLVM-EMAELGPLNKYLQQNRH------------VKD----KNIIE 473 IV ++G C LV+ E G L +L++ R KD ++++ Sbjct: 106 NIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLTLEHLLS 165 Query: 474 LVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGK 533 +QV+ GM +L N +HRDLAARN+LL + KI DFGL++ ++ D NY + + + Sbjct: 166 FSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSNYVD-KGNAR 224 Query: 534 WPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMK-GSEVTAMLEKGERMG 592 PVKW APE I ++ +SDVWS+G+ +WE FS G PY GM S+ M+++G RM Sbjct: 225 LPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMS 284 Query: 593 CPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 P P EMYD+M CW D + RP F + Sbjct: 285 SPEYAPAEMYDIMKTCWDADPDKRPTFKQI 314 >4E20-A nrPDB Length = 290 Score = 161 bits (408), Expect = 8e-40, Method: Compositional matrix adjust. Identities = 103/265 (38%), Positives = 136/265 (51%), Gaps = 23/265 (8%) Query: 375 KELGSGNFGTVKKGYYQMKK--VVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 ++LG G+FG V Y + VAVK LK E P L+ E +++ L + +I Sbjct: 14 RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALK-EGCGPQLRSGWQREIEILRTLYHEHI 72 Query: 433 VRMIGICEAE---SWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEES 488 V+ G CE + S LVME LG L YL RH V ++ Q+ GM YL Sbjct: 73 VKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLP--RHCVGLAQLLLFAQQICEGMAYLHAQ 130 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 +++HR LAARNVLL KI DFGL+KA+ YY+ + G PV WYAPEC+ K Sbjct: 131 HYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECK 190 Query: 549 FSSKSDVWSFGVLMWEAFSY---GQKPYRG-----------MKGSEVTAMLEKGERMGCP 594 F SDVWSFGV ++E +Y Q P+ M +T +LE+GER+ P Sbjct: 191 FYYASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVLRLTELLERGERLPRP 250 Query: 595 AGCPREMYDLMNLCWTYDVENRPGF 619 CP E+Y LM CW + RP F Sbjct: 251 DRCPCEIYHLMKNCWETEASFRPTF 275 >5HLW-A nrPDB Length = 299 Score = 160 bits (405), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 96/270 (35%), Positives = 146/270 (54%), Gaps = 12/270 (4%) Query: 369 LLTLEDKELGSGNFGTVKKGYY---QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 425 L+ ++ +G G+FG V G KK+ AVK L N D + L E +M+ Sbjct: 20 LIVHFNEVIGRGHFGCVYHGTLLDNDGKKI--HCAVKSL-NRITDIGEVSQFLTEGIIMK 76 Query: 426 QLDNPYIVRMIGIC--EAESWMLVMEMAELGPLNKYLQQNRHVKD-KNIIELVHQVSMGM 482 +P ++ ++GIC S ++V+ + G L +++ H K++I QV+ GM Sbjct: 77 DFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGM 136 Query: 483 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKA--QTHGKWPVKWYA 540 KYL FVHRDLAARN +L + K++DFGL++ + D+ YY +T K PVKW A Sbjct: 137 KYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMH-DKEYYSVHNKTGAKLPVKWMA 195 Query: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600 E + KF++KSDVWSFGVL+WE + G PY + ++T L +G R+ P CP Sbjct: 196 LESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDP 255 Query: 601 MYDLMNLCWTYDVENRPGFAAVELRLRNYY 630 +Y++M CW E RP F+ + R+ + Sbjct: 256 LYEVMLKCWHPKAEMRPSFSELVSRISAIF 285 >3ZBF-A nrPDB Length = 322 Score = 159 bits (403), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 96/278 (34%), Positives = 156/278 (56%), Gaps = 22/278 (7%) Query: 377 LGSGNFGTVKKGYYQMKKVVKT----VAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 LGSG FG V +G V + VAVK LK + D K E L EA++M + ++P I Sbjct: 41 LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQE-KIEFLKEAHLMSKFNHPNI 99 Query: 433 VRMIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVK-------DKNIIELVHQVSMGMKY 484 ++ +G+C E +++E+ E G L YL++ R ++++L +S G Y Sbjct: 100 LKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVY 159 Query: 485 LEESNFVHRDLAARNVLLVTQHY-----AKISDFGLSKALRADENYYKAQTHGKWPVKWY 539 LE +F+HRDLAARN L+ + Y KI DFGL++ + ++ YY+ + G PV+W Sbjct: 160 LERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKND-YYRKRGEGLLPVRWM 218 Query: 540 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR 599 APE + F+++SDVWSFG+L+WE + G +PY +V ++ G R+ P CP Sbjct: 219 APESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPD 278 Query: 600 EMYDLMNLCWTYDVENRPGFAAVELRL---RNYYYDVV 634 ++++LM CW + + RP F ++ +L RN++ + + Sbjct: 279 DLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSI 316 >2OGV-A nrPDB Length = 317 Score = 157 bits (396), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 95/264 (35%), Positives = 148/264 (56%), Gaps = 18/264 (6%) Query: 375 KELGSGNFG-TVKKGYYQMKK--VVKTVAVKILKNEANDPALKDELLAEANVMQQL-DNP 430 K LG+G FG V+ + + K V VAVK+LK+ A+ K+ L++E +M L + Sbjct: 44 KTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADE-KEALMSELKIMSHLGQHE 102 Query: 431 YIVRMIGICEAESWMLVM-EMAELGPLNKYLQQN----------RHVKDKNIIELVHQVS 479 IV ++G C +LV+ E G L +L++ R ++ ++++ QV+ Sbjct: 103 NIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFSSQVA 162 Query: 480 MGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY 539 GM +L N +HRD+AARNVLL H AKI DFGL++ + D NY + + + PVKW Sbjct: 163 QGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYI-VKGNARLPVKWM 221 Query: 540 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG-MKGSEVTAMLEKGERMGCPAGCP 598 APE I ++ +SDVWS+G+L+WE FS G PY G + S+ +++ G +M PA P Sbjct: 222 APESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAP 281 Query: 599 REMYDLMNLCWTYDVENRPGFAAV 622 + +Y +M CW + +RP F + Sbjct: 282 KNIYSIMQACWALEPTHRPTFQQI 305 >3KRL-A nrPDB Length = 335 Score = 156 bits (395), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 95/270 (35%), Positives = 147/270 (54%), Gaps = 24/270 (8%) Query: 375 KELGSGNFG-TVKKGYYQMKK--VVKTVAVKILKNEANDPALKDELLAEANVMQQL-DNP 430 K LG+G FG V+ + + K V VAVK+LK+ A+ K+ L++E +M L + Sbjct: 52 KTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADE-KEALMSELKIMSHLGQHE 110 Query: 431 YIVRMIGICEAESWMLVM-EMAELGPLNKYLQQNR----------------HVKDKNIIE 473 IV ++G C +LV+ E G L +L++ R + ++++ Sbjct: 111 NIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLLH 170 Query: 474 LVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGK 533 QV+ GM +L N +HRD+AARNVLL H AKI DFGL++ + D NY + + + Sbjct: 171 FSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYI-VKGNAR 229 Query: 534 WPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG-MKGSEVTAMLEKGERMG 592 PVKW APE I ++ +SDVWS+G+L+WE FS G PY G + S+ +++ G +M Sbjct: 230 LPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMA 289 Query: 593 CPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 PA P+ +Y +M CW + +RP F + Sbjct: 290 QPAFAPKNIYSIMQACWALEPTHRPTFQQI 319 >3BEA-A nrPDB Length = 333 Score = 156 bits (395), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 95/268 (35%), Positives = 147/268 (54%), Gaps = 22/268 (8%) Query: 375 KELGSGNFG-TVKKGYYQMKK--VVKTVAVKILKNEANDPALKDELLAEANVMQQL-DNP 430 K LG+G FG V+ + + K V VAVK+LK+ A+ K+ L++E +M L + Sbjct: 52 KTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADE-KEALMSELKIMSHLGQHE 110 Query: 431 YIVRMIGICEAESWMLVM-EMAELGPLNKYLQQ--------------NRHVKDKNIIELV 475 IV ++G C +LV+ E G L +L++ N + ++++ Sbjct: 111 NIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLLHFS 170 Query: 476 HQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWP 535 QV+ GM +L N +HRD+AARNVLL H AKI DFGL++ + D NY + + + P Sbjct: 171 SQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYI-VKGNARLP 229 Query: 536 VKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG-MKGSEVTAMLEKGERMGCP 594 VKW APE I ++ +SDVWS+G+L+WE FS G PY G + S+ +++ G +M P Sbjct: 230 VKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQP 289 Query: 595 AGCPREMYDLMNLCWTYDVENRPGFAAV 622 A P+ +Y +M CW + +RP F + Sbjct: 290 AFAPKNIYSIMQACWALEPTHRPTFQQI 317 >3C1X-A nrPDB Length = 373 Score = 155 bits (393), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 93/269 (34%), Positives = 144/269 (53%), Gaps = 10/269 (3%) Query: 369 LLTLEDKELGSGNFGTVKKGYY---QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 425 L+ ++ +G G+FG V G KK+ AVK L N D + L E +M+ Sbjct: 89 LIVHFNEVIGRGHFGCVYHGTLLDNDGKKI--HCAVKSL-NRITDIGEVSQFLTEGIIMK 145 Query: 426 QLDNPYIVRMIGIC--EAESWMLVMEMAELGPLNKYLQQNRHVKD-KNIIELVHQVSMGM 482 +P ++ ++GIC S ++V+ + G L +++ H K++I QV+ GM Sbjct: 146 DFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGM 205 Query: 483 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADE-NYYKAQTHGKWPVKWYAP 541 K+L FVHRDLAARN +L + K++DFGL++ + E + +T K PVKW A Sbjct: 206 KFLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMAL 265 Query: 542 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREM 601 E + KF++KSDVWSFGVL+WE + G PY + ++T L +G R+ P CP + Sbjct: 266 ESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPL 325 Query: 602 YDLMNLCWTYDVENRPGFAAVELRLRNYY 630 Y++M CW E RP F+ + R+ + Sbjct: 326 YEVMLKCWHPKAEMRPSFSELVSRISAIF 354 >5KMM-A nrPDB Length = 329 Score = 154 bits (390), Expect = 8e-38, Method: Compositional matrix adjust. Identities = 95/273 (34%), Positives = 145/273 (53%), Gaps = 26/273 (9%) Query: 376 ELGSGNFGTV--KKGYYQMKKVVKT-VAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 ELG G FG V + + + + K VAVK LK EA++ A +D EA ++ L + +I Sbjct: 42 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK-EASESARQD-FQREAELLTMLQHQHI 99 Query: 433 VRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDK-----------------NIIEL 474 VR G+C E ++V E G LN++L+ H D ++ + Sbjct: 100 VRFFGVCTEGRPLLMVFEYMRHGDLNRFLRS--HGPDAKLLAGGEDVAPGPLGLGQLLAV 157 Query: 475 VHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKW 534 QV+ GM YL +FVHRDLA RN L+ KI DFG+S+ + + +YY+ Sbjct: 158 ASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYST-DYYRVGGRTML 216 Query: 535 PVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP 594 P++W PE I Y KF+++SDVWSFGV++WE F+YG++P+ + +E + +G + P Sbjct: 217 PIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERP 276 Query: 595 AGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 CP E+Y +M CW + + R V RL+ Sbjct: 277 RACPPEVYAIMRGCWQREPQQRHSIKDVHARLQ 309 >3AOX-A nrPDB Length = 344 Score = 154 bits (388), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 99/279 (35%), Positives = 150/279 (53%), Gaps = 27/279 (9%) Query: 367 RKLLTLEDKELGSGNFGTVKKGYYQMKKVVKT-----VAVKILKNEANDPALKDEL--LA 419 RK +TL + LG G FG V +G Q+ + VAVK L ++ +DEL L Sbjct: 46 RKNITL-IRGLGHGAFGEVYEG--QVSGMPNDPSPLQVAVKTLPEVCSE---QDELDFLM 99 Query: 420 EANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDK-------NI 471 EA ++ + ++ IVR IG+ ++ +++E+ G L +L++ R + ++ Sbjct: 100 EALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDL 159 Query: 472 IELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQ---HYAKISDFGLSKAL-RADENYYK 527 + + ++ G +YLEE++F+HRD+AARN LL AKI DFG+++ + RA +YY+ Sbjct: 160 LHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRA--SYYR 217 Query: 528 AQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 PVKW PE F+SK+D WSFGVL+WE FS G PY EV + Sbjct: 218 KGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTS 277 Query: 588 GERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 626 G RM P CP +Y +M CW + E+RP FA + R+ Sbjct: 278 GGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERI 316 >4R7H-A nrPDB Length = 343 Score = 154 bits (388), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 95/277 (34%), Positives = 148/277 (53%), Gaps = 31/277 (11%) Query: 375 KELGSGNFG-TVKKGYYQMKK--VVKTVAVKILKNEANDPALKDELLAEANVMQQL-DNP 430 K LG+G FG V+ + + K V VAVK+LK+ A+ K+ L++E +M L + Sbjct: 56 KTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADE-KEALMSELKIMSHLGQHE 114 Query: 431 YIVRMIGICEAESWMLVM-EMAELGPLNKYLQQ-----------------------NRHV 466 IV ++G C +LV+ E G L +L++ R + Sbjct: 115 NIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPL 174 Query: 467 KDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYY 526 + ++++ QV+ GM +L N +HRD+AARNVLL H AKI DFGL++ + D NY Sbjct: 175 ELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYI 234 Query: 527 KAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG-MKGSEVTAML 585 + + + PVKW APE I ++ +SDVWS+G+L+WE FS G PY G + S+ ++ Sbjct: 235 -VKGNARLPVKWMAPESIFDSVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLV 293 Query: 586 EKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 + G +M PA P+ +Y +M CW + +RP F + Sbjct: 294 KDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 330 >3G0E-A nrPDB Length = 336 Score = 153 bits (386), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 99/272 (36%), Positives = 144/272 (52%), Gaps = 26/272 (9%) Query: 375 KELGSGNFG-TVKKGYYQMKK--VVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPY 431 K LG+G FG V+ Y + K TVAVK+LK A+ ++ L++E V+ L N Sbjct: 52 KTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTE-REALMSELKVLSYLGNHM 110 Query: 432 -IVRMIGICEAESWMLVM-EMAELGPLNKYLQQNRH------------------VKDKNI 471 IV ++G C LV+ E G L +L++ R + +++ Sbjct: 111 NIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDELALDLEDL 170 Query: 472 IELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTH 531 + +QV+ GM +L N +HRDLAARN+LL KI DFGL++ ++ D NY + + Sbjct: 171 LSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYV-VKGN 229 Query: 532 GKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMK-GSEVTAMLEKGER 590 + PVKW APE I ++ +SDVWS+G+ +WE FS G PY GM S+ M+++G R Sbjct: 230 ARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFR 289 Query: 591 MGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 M P P EMYD+M CW D RP F + Sbjct: 290 MLSPEHAPAEMYDIMKTCWDADPLKRPTFKQI 321 >6FEX-A nrPDB Length = 321 Score = 149 bits (377), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 96/306 (31%), Positives = 157/306 (51%), Gaps = 53/306 (17%) Query: 360 PKEVYLDRKLLTLEDKELGSGNFG--------------------TVKKGYYQMKKVVKTV 399 P V R L ++K LG G FG V+KG+ + V Sbjct: 8 PPRVDFPRSRLRFKEK-LGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLL------V 60 Query: 400 AVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNK 458 AVKIL+ +A A +++ L E +M +L +P I+R++G+C + + ++ + E G LN+ Sbjct: 61 AVKILRPDATKNA-RNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQ 119 Query: 459 YLQQNRHVKDKN--------------IIELVHQVSMGMKYLEESNFVHRDLAARNVLLVT 504 +L + ++DK ++ + Q++ GM+YL NFVHRDLA RN L+ Sbjct: 120 FLSAH-QLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGE 178 Query: 505 QHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWE 564 KI+DFG+S+ L A + YY+ Q P++W A ECI KF++ SDVW+FGV +WE Sbjct: 179 NFTIKIADFGMSRNLYAGD-YYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWE 237 Query: 565 AFSYGQ-KPYRGMKGSEVTA-----MLEKGER--MGCPAGCPREMYDLMNLCWTYDVENR 616 + +P+ + +V ++G + + P CP+ +Y+LM CW+ + E R Sbjct: 238 VLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQR 297 Query: 617 PGFAAV 622 P F+ + Sbjct: 298 PPFSQL 303 >3CJF-A nrPDB Length = 309 Score = 149 bits (376), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 109/311 (35%), Positives = 159/311 (51%), Gaps = 32/311 (10%) Query: 339 EALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFG-TVKKGYYQMKKV-- 395 + LP+D PY + P+ DR L K LG G FG ++ + + K Sbjct: 4 DELPLDEHCERLPYDASKWEFPR----DRLNL---GKPLGRGAFGQVIEADAFGIDKTAT 56 Query: 396 VKTVAVKILKNEANDP---ALKDELLAEANVMQQLDNPYIVRMIGICEAES--WMLVMEM 450 +TVAVK+LK A AL EL ++ L+ +V ++G C M+++E Sbjct: 57 CRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLN---VVNLLGACTKPGGPLMVIVEF 113 Query: 451 AELGPLNKYLQQNRH----VKD--KNIIELVH------QVSMGMKYLEESNFVHRDLAAR 498 + G L+ YL+ R+ KD K+ + L H QV+ GM++L +HRDLAAR Sbjct: 114 CKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAAR 173 Query: 499 NVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSF 558 N+LL ++ KI DFGL++ + D +Y + + + P+KW APE I ++ +SDVWSF Sbjct: 174 NILLSEKNVVKICDFGLARDIYKDPDYVR-KGDARLPLKWMAPETIFDRVYTIQSDVWSF 232 Query: 559 GVLMWEAFSYGQKPYRGMK-GSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRP 617 GVL+WE FS G PY G+K E L++G RM P EMY M CW + RP Sbjct: 233 GVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRP 292 Query: 618 GFAAVELRLRN 628 F+ + L N Sbjct: 293 TFSELVEHLGN 303 >6BSD-A nrPDB Length = 876 Score = 149 bits (376), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 101/327 (30%), Positives = 168/327 (51%), Gaps = 47/327 (14%) Query: 325 PELAPWAADKGPQREALPMDTEVYESPYADPE--EIRPKEVYLDRKLLTLEDKELGSGNF 382 P L P A GP R P ++ + + E+ EV + L++L D L Sbjct: 552 PALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSL-DFPL----- 605 Query: 383 GTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC-EA 441 V+KG+ + VAVKIL+ +A A +++ L E +M +L +P I+R++G+C + Sbjct: 606 -NVRKGHPLL------VAVKILRPDATKNA-RNDFLKEVKIMSRLKDPNIIRLLGVCVQD 657 Query: 442 ESWMLVMEMAELGPLNKYLQQNRHVKDKN--------------------IIELVHQVSMG 481 + ++ + E G LN++L ++ ++DK ++ + Q++ G Sbjct: 658 DPLCMITDYMENGDLNQFLSAHQ-LEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASG 716 Query: 482 MKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 541 M+YL NFVHRDLA RN L+ KI+DFG+S+ L A + YY+ Q P++W A Sbjct: 717 MRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGD-YYRVQGRAVLPIRWMAW 775 Query: 542 ECINYYKFSSKSDVWSFGVLMWEAFSYGQ-KPYRGMKGSEVTA-----MLEKGER--MGC 593 ECI KF++ SDVW+FGV +WE + +P+ + +V ++G + + Sbjct: 776 ECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSR 835 Query: 594 PAGCPREMYDLMNLCWTYDVENRPGFA 620 P CP+ +Y+LM CW+ + E RP F+ Sbjct: 836 PPACPQGLYELMLRCWSRESEQRPPFS 862 >4XUF-A nrPDB Length = 297 Score = 149 bits (375), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 98/274 (35%), Positives = 143/274 (52%), Gaps = 31/274 (11%) Query: 375 KELGSGNFGTVKKGY-YQMKK--VVKTVAVKILKNEANDPALKDELLAEANVMQQL-DNP 430 K LGSG FG V Y + K V VAVK+LK +A D + ++ L++E +M QL + Sbjct: 15 KVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKA-DSSEREALMSELKMMTQLGSHE 73 Query: 431 YIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIE---------------- 473 IV ++G C + L+ E G L YL+ R ++ IE Sbjct: 74 NIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLNVL 133 Query: 474 -------LVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYY 526 +QV+ GM++LE + VHRDLAARNVL+ KI DFGL++ + +D NY Sbjct: 134 TFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYV 193 Query: 527 KAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMK-GSEVTAML 585 + + + PVKW APE + ++ KSDVWS+G+L+WE FS G PY G+ + ++ Sbjct: 194 -VRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLI 252 Query: 586 EKGERMGCPAGCPREMYDLMNLCWTYDVENRPGF 619 + G +M P E+Y +M CW +D RP F Sbjct: 253 QNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSF 286 >5X02-A nrPDB Length = 347 Score = 149 bits (375), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 98/274 (35%), Positives = 143/274 (52%), Gaps = 31/274 (11%) Query: 375 KELGSGNFGTVKKGY-YQMKK--VVKTVAVKILKNEANDPALKDELLAEANVMQQL-DNP 430 K LGSG FG V Y + K V VAVK+LK +A D + ++ L++E +M QL + Sbjct: 54 KVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKA-DSSEREALMSELKMMTQLGSHE 112 Query: 431 YIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIE---------------- 473 IV ++G C + L+ E G L YL+ R ++ IE Sbjct: 113 NIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLNVL 172 Query: 474 -------LVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYY 526 +QV+ GM++LE + VHRDLAARNVL+ KI DFGL++ + +D NY Sbjct: 173 TFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYV 232 Query: 527 KAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMK-GSEVTAML 585 + + + PVKW APE + ++ KSDVWS+G+L+WE FS G PY G+ + ++ Sbjct: 233 -VRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLI 291 Query: 586 EKGERMGCPAGCPREMYDLMNLCWTYDVENRPGF 619 + G +M P E+Y +M CW +D RP F Sbjct: 292 QNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSF 325 >5GRN-A nrPDB Length = 356 Score = 147 bits (370), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 101/278 (36%), Positives = 140/278 (50%), Gaps = 36/278 (12%) Query: 375 KELGSGNFGTVKKGY-YQMKKV--VKTVAVKILKNEANDPALKDELLAEANVMQQLDNPY 431 + LGSG FG V +G Y + + V VAVK+LK A K L++E +M L P+ Sbjct: 52 RVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSE-KQALMSELKIMTHL-GPH 109 Query: 432 --IVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRH------------------VKDKN 470 IV ++G C + ++ E G L YL +NR + D N Sbjct: 110 LNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDN 169 Query: 471 --------IIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRAD 522 ++ +QV+ GM++L N VHRDLAARNVLL KI DFGL++ + D Sbjct: 170 SEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHD 229 Query: 523 ENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMK-GSEV 581 NY ++ PVKW APE I +++ SDVWS+G+L+WE FS G PY GM S Sbjct: 230 SNYV-SKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTF 288 Query: 582 TAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGF 619 ++ G RM P E+Y++M CW + E RP F Sbjct: 289 YNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSF 326 >4UYA-A nrPDB Length = 340 Score = 129 bits (324), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 96/279 (34%), Positives = 137/279 (49%), Gaps = 31/279 (11%) Query: 360 PKEVYLDRKLLTLEDKEL-GSGNFGTVKKGYYQMKKVVKTVAVKILKN--EANDPALKDE 416 P V +R LE KEL G+G FG V + +Q ++V AVK + E + A + Sbjct: 20 PVHVAFER----LELKELIGAGGFGQVYRATWQGQEV----AVKAARQDPEQDAAAAAES 71 Query: 417 LLAEANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELV 475 + EA + L +P I+ + G+C + + LV+E A G LN+ L R + ++ Sbjct: 72 VRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALA-GRRIPPHVLVNWA 130 Query: 476 HQVSMGMKYLEESNFV---HRDLAARNVLL--------VTQHYAKISDFGLSKALRADEN 524 Q++ GM YL E FV HRDL + N+LL + KI+DFGL+ R Sbjct: 131 VQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLA---REWHR 187 Query: 525 YYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAM 584 K T G + W APE I FS SD+WS+GVL+WE + G+ PYRG+ G V Sbjct: 188 TTKMATAGAY--AWMAPEVIKSSLFSKGSDIWSYGVLLWELLT-GEVPYRGIDGLAVAYG 244 Query: 585 LEKGE-RMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 + + + P+ CP LM CW D RP FA + Sbjct: 245 VAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALI 283 >4UY9-A nrPDB Length = 323 Score = 127 bits (319), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 88/273 (32%), Positives = 136/273 (49%), Gaps = 27/273 (9%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALK--DELLAEAN 422 +D LTLE+ +G G FG V + ++ + VAVK +++ ++ + + + EA Sbjct: 6 IDFAELTLEEI-IGIGGFGKVYRAFW----IGDEVAVKAARHDPDEDISQTIENVRQEAK 60 Query: 423 VMQQLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMG 481 + L +P I+ + G+C E + LVME A GPLN+ L R D ++ Q++ G Sbjct: 61 LFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDI-LVNWAVQIARG 119 Query: 482 MKYLEESNFV---HRDLAARNVLLV--------TQHYAKISDFGLSKALRADENYYKAQT 530 M YL + V HRDL + N+L++ + KI+DFGL++ A T Sbjct: 120 MNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGT 179 Query: 531 HGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE- 589 + W APE I FS SDVWS+GVL+WE + G+ P+RG+ G V + + Sbjct: 180 YA-----WMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVAMNKL 233 Query: 590 RMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 + P+ CP LM CW D +RP F + Sbjct: 234 ALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNI 266 >4RT7-A nrPDB Length = 415 Score = 126 bits (317), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 61/152 (40%), Positives = 93/152 (61%), Gaps = 2/152 (1%) Query: 469 KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKA 528 ++++ +QV+ GM++LE + VHRDLAARNVL+ KI DFGL++ + +D NY Sbjct: 243 EDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYV-V 301 Query: 529 QTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMK-GSEVTAMLEK 587 + + + PVKW APE + ++ KSDVWS+G+L+WE FS G PY G+ + +++ Sbjct: 302 RGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQN 361 Query: 588 GERMGCPAGCPREMYDLMNLCWTYDVENRPGF 619 G +M P E+Y +M CW +D RP F Sbjct: 362 GFKMDQPFYATEEIYIIMQSCWAFDSRKRPSF 393 >3HNG-A nrPDB Length = 360 Score = 126 bits (316), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 65/159 (40%), Positives = 96/159 (60%), Gaps = 2/159 (1%) Query: 469 KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKA 528 +++I QV+ GM++L +HRDLAARN+LL + KI DFGL++ + + +Y + Sbjct: 199 EDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVR- 257 Query: 529 QTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSE-VTAMLEK 587 + + P+KW APE I +S+KSDVWS+GVL+WE FS G PY G++ E + L + Sbjct: 258 KGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLRE 317 Query: 588 GERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 626 G RM P E+Y +M CW D + RP FA + +L Sbjct: 318 GMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL 356 >3DTC-A nrPDB Length = 271 Score = 125 bits (315), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 87/273 (31%), Positives = 135/273 (49%), Gaps = 27/273 (9%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALK--DELLAEAN 422 +D LTLE+ +G G FG V + ++ + VAVK +++ ++ + + + EA Sbjct: 4 IDFAELTLEEI-IGIGGFGKVYRAFW----IGDEVAVKAARHDPDEDISQTIENVRQEAK 58 Query: 423 VMQQLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMG 481 + L +P I+ + G+C E + LVME A GPLN+ L R D ++ Q++ G Sbjct: 59 LFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDI-LVNWAVQIARG 117 Query: 482 MKYLEESNFV---HRDLAARNVLLV--------TQHYAKISDFGLSKALRADENYYKAQT 530 M YL + V HRDL + N+L++ + KI+DFGL++ A Sbjct: 118 MNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGA 177 Query: 531 HGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE- 589 + W APE I FS SDVWS+GVL+WE + G+ P+RG+ G V + + Sbjct: 178 YA-----WMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVAMNKL 231 Query: 590 RMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 + P+ CP LM CW D +RP F + Sbjct: 232 ALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNI 264 >3VHK-A nrPDB Length = 368 Score = 124 bits (312), Expect = 9e-29, Method: Compositional matrix adjust. Identities = 66/161 (40%), Positives = 94/161 (58%), Gaps = 2/161 (1%) Query: 469 KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKA 528 +++I QV+ GM++L +HRDLAARN+LL ++ KI DFGL++ + D +Y + Sbjct: 200 EHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVR- 258 Query: 529 QTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMK-GSEVTAMLEK 587 + + P+KW APE I ++ +SDVWSFGVL+WE FS G PY G+K E L++ Sbjct: 259 KGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKE 318 Query: 588 GERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 G RM P EMY M CW + RP F+ + L N Sbjct: 319 GTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGN 359 >5X5O-A nrPDB Length = 310 Score = 120 bits (302), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 84/256 (32%), Positives = 130/256 (50%), Gaps = 33/256 (12%) Query: 378 GSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIG 437 G G+FG+V + + + K VAVK L LK E EA ++ L + I++ G Sbjct: 24 GGGSFGSVYRAKWISQD--KEVAVKKL--------LKIE--KEAEILSVLSHRNIIQFYG 71 Query: 438 -ICEAESWMLVMEMAELGPLNKYLQQNR--HVKDKNIIELVHQVSMGMKYLEES---NFV 491 I E ++ +V E A LG L Y+ NR + +I+ V+ GM YL + Sbjct: 72 VILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVI 131 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTH----GKWPVKWYAPECINYY 547 HRDL +RNV++ KI DFG S+ ++ TH G +P W APE I Sbjct: 132 HRDLKSRNVVIAADGVLKICDFGASR-------FHNHTTHMSLVGTFP--WMAPEVIQSL 182 Query: 548 KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVT-AMLEKGERMGCPAGCPREMYDLMN 606 S D +S+GV++WE + + P++G++G +V ++EK ER+ P+ CPR +L++ Sbjct: 183 PVSETCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH 241 Query: 607 LCWTYDVENRPGFAAV 622 CW D + RP F + Sbjct: 242 QCWEADAKKRPSFKQI 257 >5VO2-A nrPDB Length = 300 Score = 116 bits (291), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 81/268 (30%), Positives = 129/268 (48%), Gaps = 24/268 (8%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANV--MQQLDN 429 L+ + +GSG G V G + ++V AVK +++ L E ++ +++L + Sbjct: 15 LDLQWVGSGAQGAVFLGRFHGEEV----AVKKVRD-----------LKETDIKHLRKLKH 59 Query: 430 PYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 P I+ G+C +A + ++ME G L + L+ R V +++ ++ GM YL Sbjct: 60 PNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLH 119 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 +HRDL + N+L+ KISDFG SK L + K G V W APE I Sbjct: 120 KIIHRDLKSPNMLITYDDVVKISDFGTSKEL--SDKSTKMSFAGT--VAWMAPEVIRNEP 175 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVT-AMLEKGERMGCPAGCPREMYDLMNL 607 S K D+WSFGV++WE + G+ PY+ + S + + + P+ CP L+ Sbjct: 176 VSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQ 234 Query: 608 CWTYDVENRPGFAAVELRLRNYYYDVVN 635 CW NRP F + L L DV++ Sbjct: 235 CWNSKPRNRPSFRQILLHLDIASADVLS 262 >3PPZ-A nrPDB Length = 309 Score = 113 bits (282), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 78/260 (30%), Positives = 139/260 (53%), Gaps = 15/260 (5%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +++G+G+FGTV + + V AVKIL + +E L E +M++L +P IV Sbjct: 43 EKIGAGSFGTVHRAEWHGSDV----AVKILMEQDFHAERVNEFLREVAIMKRLRHPNIVL 98 Query: 435 MIG-ICEAESWMLVMEMAELGPLNKYLQQN---RHVKDKNIIELVHQVSMGMKYLEESN- 489 +G + + + +V E G L + L ++ + ++ + + + V+ GM YL N Sbjct: 99 FMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNP 158 Query: 490 -FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 VHRDL + N+L+ ++ K+ DFGLS+ L+A + +++ P +W APE + Sbjct: 159 PIVHRDLKSPNLLVDKKYTVKVCDFGLSR-LKA-STFLSSKSAAGTP-EWMAPEVLRDEP 215 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLE-KGERMGCPAGCPREMYDLMNL 607 + KSDV+SFGV++WE + Q+P+ + ++V A + K +R+ P ++ ++ Sbjct: 216 SNEKSDVYSFGVILWE-LATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAAIIEG 274 Query: 608 CWTYDVENRPGFAAVELRLR 627 CWT + RP FA + LR Sbjct: 275 CWTNEPWKRPSFATIMDLLR 294 >4NEU-A nrPDB Length = 333 Score = 105 bits (263), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 86/283 (30%), Positives = 135/283 (47%), Gaps = 35/283 (12%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPAL---KDELLAEANVMQQLD 428 LE EL SG FG V ++ +T + I+K P + LL EA +M +L Sbjct: 27 LESAELDSGGFGKVSLCFH------RTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLR 80 Query: 429 NPYIVRMIG-ICEAESWMLVMEMAELGPLNKYLQQNRH----VKDKNIIELVHQVSMGMK 483 + +V+++G I E + LVME E G L L+ VK + I+E++ GM Sbjct: 81 HSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIE----GMC 136 Query: 484 YLEESNFVHRDLAARNVLLVTQHYAKISDFGLSK-----ALRADENYYKAQTHGKW---- 534 YL +H+DL N+L+ + KI+D GL+ L +E+ + G Sbjct: 137 YLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNG 196 Query: 535 -PVKWYAPECINYY--KFSSKSDVWSFGVLMWEAFSYGQKPYR-GMKGSEVTAMLEKGER 590 + + APE +N K + KSDV+SF V++W F+ ++PY + ++ ++ G R Sbjct: 197 GTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFA-NKEPYENAICEQQLIMCIKSGNR 255 Query: 591 MGC---PAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYY 630 CPRE+ LM LCW + E RP F +E + R +Y Sbjct: 256 PDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFY 298 >5USZ-A nrPDB Length = 289 Score = 101 bits (251), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 74/277 (26%), Positives = 132/277 (47%), Gaps = 35/277 (12%) Query: 374 DKELGSGNFGTVKKG-------YYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQ 426 ++ LG G F + KG Y Q+ + V +K+L + + A++M + Sbjct: 13 NESLGQGTFTKIFKGVRREVGDYGQLHET--EVLLKVLDKAHRN--YSESFFEAASMMSK 68 Query: 427 LDNPYIVRMIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKNII---ELVHQVSMGM 482 L + ++V G+C + +LV E + G L+ YL++N++ NI+ E+ Q++ M Sbjct: 69 LSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCI--NILWKLEVAKQLAAAM 126 Query: 483 KYLEESNFVHRDLAARNVLLVTQH--------YAKISDFGLSKALRADENYYKAQTHGKW 534 +LEE+ +H ++ A+N+LL+ + + K+SD G+S + + + Sbjct: 127 HFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQER------ 180 Query: 535 PVKWYAPECI-NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGC 593 + W PECI N + +D WSFG +WE S G KP + E +R Sbjct: 181 -IPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYE--DRHQL 237 Query: 594 PAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYY 630 PA E+ +L+N C Y+ ++RP F A+ L + + Sbjct: 238 PAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLF 274 >4F0G-A nrPDB Length = 287 Score = 97.4 bits (241), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 73/265 (27%), Positives = 132/265 (49%), Gaps = 24/265 (9%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKD---ELLAEANVMQQLDNP 430 +K++G G FG V KG K V + IL + + + + E E +M L++P Sbjct: 24 EKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLNHP 83 Query: 431 YIVRMIGICEAESWMLVMEMAELGPL-NKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 IV++ G+ M VME G L ++ L + +K + L+ +++G++Y++ N Sbjct: 84 NIVKLYGLMHNPPRM-VMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLDIALGIEYMQNQN 142 Query: 490 --FVHRDLAARNVLLVTQH-----YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 542 VHRDL + N+ L + AK++DFGLS+ + + G + +W APE Sbjct: 143 PPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQ----QSVHSVSGLLGNF--QWMAPE 196 Query: 543 CINYYK--FSSKSDVWSFGVLMWEAFSYGQKP---YRGMKGSEVTAMLEKGERMGCPAGC 597 I + ++ K+D +SF ++++ + G+ P Y K + + E+G R P C Sbjct: 197 TIGAEEESYTEKADTYSFAMILYTILT-GEGPFDEYSYGKIKFINMIREEGLRPTIPEDC 255 Query: 598 PREMYDLMNLCWTYDVENRPGFAAV 622 P + +++ LCW+ D + RP F+ + Sbjct: 256 PPRLRNVIELCWSGDPKKRPHFSYI 280 >6FDY-U nrPDB Length = 276 Score = 97.1 bits (240), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 69/261 (26%), Positives = 135/261 (51%), Gaps = 16/261 (6%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424 LD +LT + LGSG + TV K Y + K + VA+K + ++ + A + LL E ++ Sbjct: 10 LDGFILT---ERLGSGTYATVYKAYAK-KDTREVVAIKCVAKKSLNKASVENLLTEIEIL 65 Query: 425 QQLDNPYIVRMIGI-CEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMK 483 + + +P+IV++ ++++ L+ME G L++++ R + +K + Q++ ++ Sbjct: 66 KGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQ 125 Query: 484 YLEESNFVHRDLAARNVLL--VTQHYAKISDFGLSKALRA-DENYYKAQTHGKWPVKWYA 540 +L E N H DL +N+LL + + + K++DFG ++ + DE + + P+ + A Sbjct: 126 FLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGS----PL-YMA 180 Query: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAG--CP 598 PE + ++ ++ D+WS GV+++EA +GQ P+ SE+ + + P Sbjct: 181 PEMVCQRQYDARVDLWSMGVILYEAL-FGQPPFASRSFSELEEKIRSNRVIELPLRPLLS 239 Query: 599 REMYDLMNLCWTYDVENRPGF 619 R+ DL+ D R F Sbjct: 240 RDCRDLLQRLLERDPSRRISF 260 >5ES1-A nrPDB Length = 328 Score = 95.1 bits (235), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 66/217 (30%), Positives = 106/217 (48%), Gaps = 9/217 (4%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 + +G GNF VK + + + VA+KI+ +P+ +L E +M+ L++P IV+ Sbjct: 21 RTIGKGNFAKVKLARHILTG--REVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVK 78 Query: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + + E E + LVME A G + YL + +K+K Q+ + Y + N VHR Sbjct: 79 LFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHR 138 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS-K 552 DL A N+LL + KI+DFG S K T P + APE K+ + Sbjct: 139 DLKAENLLLDAEANIKIADFGFSNEFTLGS---KLDTFCGSP-PYAAPELFQGKKYDGPE 194 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 D+WS GV+++ S G P+ G E+ + +G+ Sbjct: 195 VDIWSLGVILYTLVS-GSLPFDGHNLKELRERVLRGK 230 >3OMV-A nrPDB Length = 307 Score = 94.7 bits (234), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 81/276 (29%), Positives = 125/276 (45%), Gaps = 26/276 (9%) Query: 357 EIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE 416 EI EV L ++ GSG+FGTV KG + VAVKILK P Sbjct: 32 EIEASEVMLSTRI--------GSGSFGTVYKGKWH-----GDVAVKILKVVDPTPEQFQA 78 Query: 417 LLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQ-QNRHVKDKNIIELV 475 E V+++ + I+ +G ++ +V + E L K+L Q + +I++ Sbjct: 79 FRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIA 138 Query: 476 HQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKA-LRADENYYKAQTHGKW 534 Q + GM YL N +HRD+ + N+ L KI DFGL+ R + Q G Sbjct: 139 RQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGS- 197 Query: 535 PVKWYAPECINYYK---FSSKSDVWSFGVLMWEAFSYGQKPYRGMKG-SEVTAMLEKG-- 588 V W APE I FS +SDV+S+G++++E + G+ PY + ++ M+ +G Sbjct: 198 -VLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRGYA 255 Query: 589 --ERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 + CP+ M L+ C E RP F + Sbjct: 256 SPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQI 291 >5HI2-A nrPDB Length = 283 Score = 94.7 bits (234), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 72/258 (27%), Positives = 120/258 (46%), Gaps = 23/258 (8%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 + +GSG+FGTV KG + VAVK+L P E V+++ + I+ Sbjct: 26 QRIGSGSFGTVYKGKWH-----GDVAVKMLT-----PQQLQAFKNEVGVLRKTRHVNILL 75 Query: 435 MIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFVHR 493 +G +V + E L +L + + K +I++ Q + GM YL + +HR Sbjct: 76 FMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHR 135 Query: 494 DLAARNVLLVTQHYAKISDFGLSKA-LRADENYYKAQTHGKWPVKWYAPECINYYK---F 549 DL + N+ L + KI DFGL+ R ++ Q G + W APE I + Sbjct: 136 DLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGS--ILWMAPEVIRMQDSNPY 193 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPYRGMKG-SEVTAMLEKG----ERMGCPAGCPREMYDL 604 S +SDV++FG++++E + GQ PY + ++ M+ +G + + CP+ M L Sbjct: 194 SFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRL 252 Query: 605 MNLCWTYDVENRPGFAAV 622 M C + RP F + Sbjct: 253 MAECLKKKRDERPSFPRI 270 >4GS6-A nrPDB Length = 315 Score = 93.2 bits (230), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 75/267 (28%), Positives = 122/267 (45%), Gaps = 26/267 (9%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424 +D K + +E+ +G G FG V K ++ K VA+K +++E+ + + E + Sbjct: 6 IDYKEIEVEEV-VGRGAFGVVCKAKWR----AKDVAIKQIESESE----RKAFIVELRQL 56 Query: 425 QQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNR---HVKDKNIIELVHQVSMG 481 ++++P IV++ G C LVME AE G L L + + + Q S G Sbjct: 57 SRVNHPNIVKLYGAC-LNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQG 115 Query: 482 MKYL---EESNFVHRDLAARNVLLVTQHYA-KISDFGLSKALRADENYYKAQTHGKWPVK 537 + YL + +HRDL N+LLV KI DFG + ++ T+ K Sbjct: 116 VAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTH------MTNNKGSAA 169 Query: 538 WYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAM--LEKGERMGCPA 595 W APE +S K DV+S+G+++WE + +KP+ + G M + G R Sbjct: 170 WMAPEVFEGSNYSEKCDVFSWGIILWEVITR-RKPFDEIGGPAFRIMWAVHNGTRPPLIK 228 Query: 596 GCPREMYDLMNLCWTYDVENRPGFAAV 622 P+ + LM CW+ D RP + Sbjct: 229 NLPKPIESLMTRCWSKDPSQRPSMEEI 255 >2HAK-A nrPDB Length = 328 Score = 92.0 bits (227), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 68/217 (31%), Positives = 104/217 (47%), Gaps = 9/217 (4%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K +G GNF VK + + + VAVKI+ +P +L E +M+ L++P IV+ Sbjct: 21 KTIGKGNFAKVKLARHVLTG--REVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVK 78 Query: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + + E E + LVME A G + YL + +K+K Q+ ++Y + VHR Sbjct: 79 LFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHR 138 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS-K 552 DL A N+LL KI+DFG S K T P + APE K+ + Sbjct: 139 DLKAENLLLDGDMNIKIADFGFSNEFTVGN---KLDTFCGSP-PYAAPELFQGKKYDGPE 194 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 DVWS GV+++ S G P+ G E+ + +G+ Sbjct: 195 VDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRGK 230 >6J5U-C nrPDB Length = 426 Score = 92.0 bits (227), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 72/211 (34%), Positives = 105/211 (49%), Gaps = 23/211 (10%) Query: 373 EDKELGSGNFGTVKKGYYQMKKVVKT-------VAVKILKNEANDPALKDELLAEANVMQ 425 +D LG G FG V KG+ + + VAVK LK E E L E N + Sbjct: 88 QDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQG--HKEWLTEVNYLG 145 Query: 426 QLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQV--SMGM 482 QL +P +V ++G C E E+ +LV E G L +L + I + V + G+ Sbjct: 146 QLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGAAKGL 205 Query: 483 KYLEE--SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQ----THGKWPV 536 +L E S ++RD A N+LL AK+SDFGL+KA +N + + THG Sbjct: 206 TFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTHG---- 261 Query: 537 KWYAPECINYYKFSSKSDVWSFGVLMWEAFS 567 + APE + + ++KSDV+SFGV++ E S Sbjct: 262 -YAAPEYVATGRLTAKSDVYSFGVVLLELIS 291 >2QNJ-A nrPDB Length = 328 Score = 91.7 bits (226), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 66/217 (30%), Positives = 104/217 (47%), Gaps = 9/217 (4%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K +G GNF VK + + + VA+KI+ +P +L E +M+ L++P IV+ Sbjct: 18 KTIGKGNFAKVKLARHILTG--REVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVK 75 Query: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + + E E + L+ME A G + YL + +K+K Q+ ++Y + VHR Sbjct: 76 LFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHR 135 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS-K 552 DL A N+LL KI+DFG S K T P + APE K+ + Sbjct: 136 DLKAENLLLDADMNIKIADFGFSNEFTVGG---KLDTFCGSP-PYAAPELFQGKKYDGPE 191 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 DVWS GV+++ S G P+ G E+ + +G+ Sbjct: 192 VDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRGK 227 >4X3F-A nrPDB Length = 337 Score = 91.7 bits (226), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 66/232 (28%), Positives = 111/232 (47%), Gaps = 32/232 (13%) Query: 379 SGNFGTVKKGYYQMKKVVKT-----------------VAVKILKNE-ANDPALKDELLAE 420 S G G Y++++++ T VAVK+LK+E ++DP + AE Sbjct: 3 SPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAE 62 Query: 421 ANVMQQLDNPYIV--------RMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNII 472 A L++P I +M G E + LVME+ PLN L++ + ++ + Sbjct: 63 ARTTAMLNHPGIASVHDYGESQMNG--EGRTAYLVMELVNGEPLNSVLKRTGRLSLRHAL 120 Query: 473 ELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHG 532 +++ Q ++ + VHRD+ N+L+ KI+DFG++KA+ A G Sbjct: 121 DMLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMG 180 Query: 533 KWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAM 584 ++ APE + S SDV+S GV+ +EA S G++P+ G G+ AM Sbjct: 181 T--AQYIAPEQALGHDASPASDVYSLGVVGYEAVS-GKRPFAG-DGALTVAM 228 >5WNL-A nrPDB Length = 342 Score = 91.3 bits (225), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 79/259 (30%), Positives = 120/259 (46%), Gaps = 16/259 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +++GSG FG V K + K +A+K + D + ELL EA M+ YI+ Sbjct: 26 EKVGSGGFGQVYKVRHVHWKT--WLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILP 83 Query: 435 MIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE--ESNFVH 492 + GIC+ E LVME E G L K L D +VH+ ++GM +L +H Sbjct: 84 VYGICQ-EPVGLVMEYMETGSLEKLLASEPLPWDLRF-RIVHETAVGMNFLHCMSPPLLH 141 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK--FS 550 +L N+LL ++ KISDFGL+K ++ + + + PE I F Sbjct: 142 LNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKSRLFD 201 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGS-EVTAMLEKGERMGCPAGC-PR-----EMYD 603 +K DV+SF +++W + +KP+ K + + KG R P C PR + Sbjct: 202 TKHDVYSFAIVIWGVLTQ-KKPFADEKNILHIMMKVVKGHRPELPPICRPRPRACASLIG 260 Query: 604 LMNLCWTYDVENRPGFAAV 622 LM CW D + RP F + Sbjct: 261 LMQRCWHADPQVRPTFQEI 279 >4OW8-A nrPDB Length = 283 Score = 91.3 bits (225), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 64/230 (27%), Positives = 111/230 (48%), Gaps = 28/230 (12%) Query: 379 SGNFGTVKKGYYQMKKVVKT-----------------VAVKILKNE-ANDPALKDELLAE 420 S G G Y++++++ T VAVK+LK+E ++DP + AE Sbjct: 2 SPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAE 61 Query: 421 ANVMQQLDNPYIVRMIGICEAE------SWMLVMEMAELGPLNKYLQQNRHVKDKNIIEL 474 A L++P I + E++ + LVME+ PLN L++ + ++ +++ Sbjct: 62 ARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDM 121 Query: 475 VHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKW 534 + Q ++ + VHRD+ N+L+ KI+DFG++KA+ A G Sbjct: 122 LEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGT- 180 Query: 535 PVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAM 584 ++ APE + S SDV+S GV+ +EA S G++P+ G G+ AM Sbjct: 181 -AQYIAPEQALGHDASPASDVYSLGVVGYEAVS-GKRPFAG-DGALTVAM 227 >5KZ7-A nrPDB Length = 346 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 71/218 (32%), Positives = 108/218 (49%), Gaps = 11/218 (5%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNPYIV 433 K +G GNF VK + + K VAVKI+ K + N +L+ +L E +M+ L++P IV Sbjct: 39 KTIGKGNFAKVKLARHILTG--KEVAVKIIDKTQLNSSSLQ-KLFREVRIMKVLNHPNIV 95 Query: 434 RMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 ++ + E E + LVME A G + YL + +K+K Q+ ++Y + VH Sbjct: 96 KLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVH 155 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS- 551 RDL A N+LL KI+DFG S K T P + APE K+ Sbjct: 156 RDLKAENLLLDADMNIKIADFGFSNEFTFGN---KLDTFCGSP-PYAAPELFQGKKYDGP 211 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 + DVWS GV+++ S G P+ G E+ + +G+ Sbjct: 212 EVDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRGK 248 >6C9D-A nrPDB Length = 459 Score = 90.9 bits (224), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 67/217 (30%), Positives = 104/217 (47%), Gaps = 9/217 (4%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K +G GNF VK + + + VAVKI+ +P +L E +M+ L++P IV+ Sbjct: 27 KTIGKGNFAKVKLARHVLTG--REVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVK 84 Query: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + + E E + LVME A G + YL + +K+K Q+ ++Y + VHR Sbjct: 85 LFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHR 144 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS-K 552 DL A N+LL KI+DFG S + G P + APE K+ + Sbjct: 145 DLKAENLLLDGDMNIKIADFGFSNEFTVGNKL--DEFCGSPP--YAAPELFQGKKYDGPE 200 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 DVWS GV+++ S G P+ G E+ + +G+ Sbjct: 201 VDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRGK 236 >6B2Q-A nrPDB Length = 317 Score = 90.5 bits (223), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 64/230 (27%), Positives = 111/230 (48%), Gaps = 28/230 (12%) Query: 379 SGNFGTVKKGYYQMKKVVKT-----------------VAVKILKNE-ANDPALKDELLAE 420 S G G Y++++++ T VAVK+LK+E ++DP + AE Sbjct: 23 SPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAE 82 Query: 421 ANVMQQLDNPYIVRMIGICEAE------SWMLVMEMAELGPLNKYLQQNRHVKDKNIIEL 474 A L++P I + E++ + LVME+ PLN L++ + ++ +++ Sbjct: 83 ARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDM 142 Query: 475 VHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKW 534 + Q ++ + VHRD+ N+L+ KI+DFG++KA+ A G Sbjct: 143 LEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGT- 201 Query: 535 PVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAM 584 ++ APE + S SDV+S GV+ +EA S G++P+ G G+ AM Sbjct: 202 -AQYIAPEQALGHDASPASDVYSLGVVGYEAVS-GKRPFAG-DGALTVAM 248 >2Z7Q-A nrPDB Length = 321 Score = 90.5 bits (223), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 69/270 (25%), Positives = 136/270 (50%), Gaps = 19/270 (7%) Query: 375 KELGSGNFGTVKKGYYQMKKVVK-----TVAVKILKNEANDPALKDELLAEANVMQQLDN 429 K LG G+FG V + ++KV + A+K+LK + E +++ +++ Sbjct: 34 KVLGQGSFGKV----FLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNH 89 Query: 430 PYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 P++V++ + E + L+++ G L L + ++++ + ++++G+ +L Sbjct: 90 PFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSL 149 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 ++RDL N+LL + + K++DFGLSK A ++ KA + V++ APE +N Sbjct: 150 GIIYRDLKPENILLDEEGHIKLTDFGLSK--EAIDHEKKAYSFCG-TVEYMAPEVVNRQG 206 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLC 608 S +D WS+GVLM+E + G P++G E ++ K ++G P E L+ Sbjct: 207 HSHSADWWSYGVLMFEMLT-GSLPFQGKDRKETMTLILKA-KLGMPQFLSTEAQSLLRAL 264 Query: 609 WTYDVENRPGF---AAVELRLRNYYYDVVN 635 + + NR G A E++ R+ +Y ++ Sbjct: 265 FKRNPANRLGSGPDGAEEIK-RHVFYSTID 293 >5C01-A nrPDB Length = 342 Score = 90.5 bits (223), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 66/236 (27%), Positives = 111/236 (47%), Gaps = 24/236 (10%) Query: 399 VAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLN 457 V +K+L +D AL A++M Q+ + ++ + G+C ++V E E GPL+ Sbjct: 110 VVLKVLDPSHHDIALA--FYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLD 167 Query: 458 KYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV-------TQHYAK 509 +L++ R HV + + Q++ + YLE N VH ++ RN+LL T + K Sbjct: 168 VWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIK 227 Query: 510 ISDFGLS-KALRADENYYKAQTHGKWPVKWYAPECI--NYYKFSSKSDVWSFGVLMWEAF 566 +SD G+ AL +E + + W APEC+ S+ D W FG + E Sbjct: 228 LSDPGVGLGALSREERVER--------IPWLAPECLPGGANSLSTAMDKWGFGATLLEIC 279 Query: 567 SYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 G+ P + SE ++ R+ P+ CP ++ L + C TY+ RP F + Sbjct: 280 FDGEAPLQSRSPSEKEHFYQRQHRLPEPS-CP-QLATLTSQCLTYEPTQRPSFRTI 333 >5D9K-A nrPDB Length = 330 Score = 90.5 bits (223), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 67/269 (24%), Positives = 132/269 (49%), Gaps = 17/269 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVV-----KTVAVKILKNEANDPALKDELLAEANVMQQLDN 429 K LG G+FG V + +KK+ + A+K+LK + E +++ ++++ Sbjct: 36 KVLGQGSFGKV----FLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNH 91 Query: 430 PYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 P+IV++ + E + L+++ G L L + ++++ + ++++ + +L Sbjct: 92 PFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSL 151 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 ++RDL N+LL + + K++DFGLSK ++ K V++ APE +N Sbjct: 152 GIIYRDLKPENILLDEEGHIKLTDFGLSK---ESIDHEKKAYSFCGTVEYMAPEVVNRRG 208 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLC 608 + +D WSFGVLM+E + G P++G E M+ K ++G P E L+ + Sbjct: 209 HTQSADWWSFGVLMFEMLT-GTLPFQGKDRKETMTMILKA-KLGMPQFLSPEAQSLLRML 266 Query: 609 WTYDVENRPGFA--AVELRLRNYYYDVVN 635 + + NR G VE R+ ++ ++ Sbjct: 267 FKRNPANRLGAGPDGVEEIKRHSFFSTID 295 >4WOV-A nrPDB Length = 317 Score = 90.5 bits (223), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 66/236 (27%), Positives = 111/236 (47%), Gaps = 24/236 (10%) Query: 399 VAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLN 457 V +K+L +D AL A++M Q+ + ++ + G+C ++V E E GPL+ Sbjct: 87 VVLKVLDPSHHDIALA--FYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLD 144 Query: 458 KYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV-------TQHYAK 509 +L++ R HV + + Q++ + YLE N VH ++ RN+LL T + K Sbjct: 145 VWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIK 204 Query: 510 ISDFGLS-KALRADENYYKAQTHGKWPVKWYAPECI--NYYKFSSKSDVWSFGVLMWEAF 566 +SD G+ AL +E + + W APEC+ S+ D W FG + E Sbjct: 205 LSDPGVGLGALSREERVER--------IPWLAPECLPGGANSLSTAMDKWGFGATLLEIC 256 Query: 567 SYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 G+ P + SE ++ R+ P+ CP ++ L + C TY+ RP F + Sbjct: 257 FDGEAPLQSRSPSEKEHFYQRQHRLPEPS-CP-QLATLTSQCLTYEPTQRPSFRTI 310 >4YFF-A nrPDB Length = 311 Score = 90.1 bits (222), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 73/268 (27%), Positives = 133/268 (49%), Gaps = 21/268 (7%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALK---DELLAEANVMQQLDNPYIV 433 +GSG+FG V KG + K VA+K + AN K D E +++ QL++P ++ Sbjct: 50 IGSGSFGKVYKGRCRNK----IVAIK--RYRANTYCSKSDVDMFCREVSILCQLNHPCVI 103 Query: 434 RMIGIC--EAESWMLVMEMAELGPLNKYLQQNRHVKD-KNIIELVHQVSMGMKYLEESN- 489 + +G C + + +V + G L L + + + D ++ + + V+ GM+YL Sbjct: 104 QFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQ 163 Query: 490 -FVHRDLAARNVLLVTQHYAKISDFGLSKALRA-DENYYKAQTHGKWPVKWYAPECIN-Y 546 +HRDL + N+LL +A ++DFG S+ L++ DE+ Q ++W APE Sbjct: 164 PIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGN---LRWMAPEVFTQC 220 Query: 547 YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTA-MLEKGERMGCPAGCPREMYDLM 605 +++ K+DV+S+ + +WE + G+ P+ +K + A M R P+ + L+ Sbjct: 221 TRYTIKADVFSYALCLWEILT-GEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLL 279 Query: 606 NLCWTYDVENRPGFAAVELRLRNYYYDV 633 W E RP F+ V ++L ++ Sbjct: 280 IRGWNACPEGRPEFSEVVMKLEECLCNI 307 >3COM-A nrPDB Length = 314 Score = 90.1 bits (222), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 60/202 (29%), Positives = 111/202 (54%), Gaps = 14/202 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 ++LG G++G+V K + K+ + VA+K + E++ E++ E ++MQQ D+P++V+ Sbjct: 35 EKLGEGSYGSVYKAIH--KETGQIVAIKQVPVESD----LQEIIKEISIMQQCDSPHVVK 88 Query: 435 MIG--ICEAESWMLVMEMAELGPLNKYLQ-QNRHVKDKNIIELVHQVSMGMKYLEESNFV 491 G + W +VME G ++ ++ +N+ + + I ++ G++YL + Sbjct: 89 YYGSYFKNTDLW-IVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKI 147 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 HRD+ A N+LL T+ +AK++DFG++ L + K T P W APE I ++ Sbjct: 148 HRDIKAGNILLNTEGHAKLADFGVAGQL--TDTMAKRNTVIGTPF-WMAPEVIQEIGYNC 204 Query: 552 KSDVWSFGVLMWEAFSYGQKPY 573 +D+WS G+ E + G+ PY Sbjct: 205 VADIWSLGITAIE-MAEGKPPY 225 >5HIE-A nrPDB Length = 302 Score = 89.7 bits (221), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 76/272 (27%), Positives = 125/272 (45%), Gaps = 35/272 (12%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 + +GSG+FGTV KG + VAVK+L P E V+++ + I+ Sbjct: 42 QRIGSGSFGTVYKGKWH-----GDVAVKMLT-----PQQLQAFKNEVGVLRKTRHVNILL 91 Query: 435 MIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKN-----IIELVHQVSMGMKYLEESN 489 +G +V + E L +L H+ + +I++ Q + GM YL + Sbjct: 92 FMGYSTKPQLAIVTQWCEGSSLYHHL----HIIETKFEMIKLIDIARQTAQGMDYLHAKS 147 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKA-LRADENYYKAQTHGKWPVKWYAPECINYYK 548 +HRDL + N+ L KI DFGL+ R ++ Q G + W APE I Sbjct: 148 IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGS--ILWMAPEVIRMQD 205 Query: 549 ---FSSKSDVWSFGVLMWEAFSYGQKPYRGMKG-SEVTAMLEKG----ERMGCPAGCPRE 600 +S +SDV++FG++++E + GQ PY + ++ M+ +G + + CP+ Sbjct: 206 KNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKA 264 Query: 601 MYDLMNLCWTYDVENRPGF----AAVELRLRN 628 M LM C + RP F A++EL R+ Sbjct: 265 MKRLMAECLKKKRDERPLFPQILASIELLARS 296 >4L00-A nrPDB Length = 304 Score = 89.7 bits (221), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 70/250 (28%), Positives = 122/250 (48%), Gaps = 31/250 (12%) Query: 387 KGYYQMKKVVKTVAVKILKNEANDPALKDELLA---EANVMQQLDNPYIVRMIGIC--EA 441 +G + KK+ V +K+L DP+ +D LA A++M+Q+ + +IV + G+C + Sbjct: 53 EGTSEEKKI--KVILKVL-----DPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV 105 Query: 442 ESWMLVMEMAELGPLNKYLQQNRHVKDKN-IIELVHQVSMGMKYLEESNFVHRDLAARNV 500 E+ ++V E E GPL+ ++ + V ++ Q++ + YLE+ + VH ++ +N+ Sbjct: 106 EN-IMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNL 164 Query: 501 LLVTQ-------HYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK-FSSK 552 LL + + K+SD G+ + + + + + W APEC+ K S Sbjct: 165 LLAREGIDSECGPFIKLSDPGIPITVLSRQECIER-------IPWIAPECVEDSKNLSVA 217 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYD 612 +D WSFG +WE G+ P + E E R P+ +E+ DLM C YD Sbjct: 218 ADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSC--KELADLMTRCMNYD 275 Query: 613 VENRPGFAAV 622 RP F A+ Sbjct: 276 PNQRPFFRAI 285 >4MVF-A nrPDB Length = 506 Score = 87.8 bits (216), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 72/222 (32%), Positives = 113/222 (50%), Gaps = 18/222 (8%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKD--ELLAEANVMQQLDNPY 431 D++LG G +G V KG + KV T + +K E D LK+ E +M++LD+P Sbjct: 62 DEKLGQGTYGCVYKG---IDKV--TNQLYAIKEEKKD-RLKNINRFFQEIEIMKKLDHPN 115 Query: 432 IVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 IV++ E ++++ L+ME+ L + +N +KN ++ Q+ + YL N Sbjct: 116 IVKLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLNI 175 Query: 491 VHRDLAARNVLLVTQH---YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY 547 VHRDL N L +++ KI DFGLSK L E T P + AP+ ++ Sbjct: 176 VHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGE---FTTTKAGTPY-YVAPQVLD-G 230 Query: 548 KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 K+ K D+WS GV+M+ G P+ G +EV ++KGE Sbjct: 231 KYDKKCDIWSSGVIMYTLLC-GYPPFYGDTDNEVLKKVKKGE 271 >4LG4-A nrPDB Length = 299 Score = 87.0 bits (214), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 60/202 (29%), Positives = 111/202 (54%), Gaps = 14/202 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 ++LG G++G+V K + K+ + VA+K + E++ E++ E ++MQQ D+PY+V+ Sbjct: 17 EKLGEGSYGSVFKAIH--KESGQVVAIKQVPVESD----LQEIIKEISIMQQCDSPYVVK 70 Query: 435 MIG--ICEAESWMLVMEMAELGPLNKYLQ-QNRHVKDKNIIELVHQVSMGMKYLEESNFV 491 G + W +VME G ++ ++ +N+ + + I ++ G++YL + Sbjct: 71 YYGSYFKNTDLW-IVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKI 129 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 HR++ A N+LL T+ +AK++DFG++ L + K T P W APE I ++ Sbjct: 130 HRNIKAGNILLNTEGHAKLADFGVAGQLT--DTMAKRNTVIGTPF-WMAPEVIQEIGYNC 186 Query: 552 KSDVWSFGVLMWEAFSYGQKPY 573 +D+WS G+ E + G+ PY Sbjct: 187 VADIWSLGITSIE-MAEGKPPY 207 >2YCR-A nrPDB Length = 323 Score = 87.0 bits (214), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 66/213 (30%), Positives = 106/213 (49%), Gaps = 23/213 (10%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEA--------NDPALKDELLAEANVMQQ 426 K LGSG G VK + +K K VA+KI+ DPAL E E ++++ Sbjct: 16 KTLGSGACGEVKLAFE--RKTCKKVAIKIISKRKFAIGSAREADPALNVE--TEIEILKK 71 Query: 427 LDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE 486 L++P I+++ +AE + +V+E+ E G L + N+ +K+ +Q+ + ++YL Sbjct: 72 LNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLH 131 Query: 487 ESNFVHRDLAARNVLLVTQH---YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPEC 543 E+ +HRDL NVLL +Q KI+DFG SK L +T P + APE Sbjct: 132 ENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS---LMRTLCGTPT-YLAPEV 187 Query: 544 ---INYYKFSSKSDVWSFGVLMWEAFSYGQKPY 573 + ++ D WS GV+++ S G P+ Sbjct: 188 LVSVGTAGYNRAVDCWSLGVILFICLS-GYPPF 219 >4QMW-A nrPDB Length = 310 Score = 87.0 bits (214), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 71/275 (25%), Positives = 125/275 (45%), Gaps = 39/275 (14%) Query: 353 ADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPA 412 ADPEE+ K LE ++G G+FG V KG + K VA+KI+ + Sbjct: 25 ADPEELFTK----------LE--KIGKGSFGEVFKGIDN--RTQKVVAIKII-DLEEAED 69 Query: 413 LKDELLAEANVMQQLDNPYIVRMIG--ICEAESWMLV--------MEMAELGPLNKYLQQ 462 +++ E V+ Q D+PY+ + G + + + W+++ +++ E GPL+ Sbjct: 70 EIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLD----- 124 Query: 463 NRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRAD 522 + I ++ ++ G+ YL +HRD+ A NVLL K++DFG++ L Sbjct: 125 -----ETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLT-- 177 Query: 523 ENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVT 582 + K T P W APE I + SK+D+WS G+ E + G+ P+ + +V Sbjct: 178 DTQIKRNTFVGTPF-WMAPEVIKQSAYDSKADIWSLGITAIE-LARGEPPHSELHPMKVL 235 Query: 583 AMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRP 617 ++ K + + + + C + RP Sbjct: 236 FLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRP 270 >6AO5-A nrPDB Length = 362 Score = 86.7 bits (213), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 60/202 (29%), Positives = 111/202 (54%), Gaps = 14/202 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 ++LG G++G+V K + K+ + VA+K + E++ E++ E ++MQQ D+PY+V+ Sbjct: 16 EKLGEGSYGSVFKAIH--KESGQVVAIKQVPVESD----LQEIIKEISIMQQCDSPYVVK 69 Query: 435 MIG--ICEAESWMLVMEMAELGPLNKYLQ-QNRHVKDKNIIELVHQVSMGMKYLEESNFV 491 G + W +VME G ++ ++ +N+ + + I ++ G++YL + Sbjct: 70 YYGSYFKNTDLW-IVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKI 128 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 HR++ A N+LL T+ +AK++DFG++ L + K T P W APE I ++ Sbjct: 129 HRNIKAGNILLNTEGHAKLADFGVAGQLT--DTMAKRNTVIGTPF-WMAPEVIQEIGYNC 185 Query: 552 KSDVWSFGVLMWEAFSYGQKPY 573 +D+WS G+ E + G+ PY Sbjct: 186 VADIWSLGITSIE-MAEGKPPY 206 >4M69-B nrPDB Length = 283 Score = 86.3 bits (212), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 63/268 (23%), Positives = 127/268 (47%), Gaps = 28/268 (10%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTV-------AVKILKNEANDPALKDELLAEANVMQQLD 428 +L + T+ +G Y V V +V I++ ND E M++ D Sbjct: 16 KLKTSKMSTIYRGEYHRSPVTIKVFNNPQAESVGIVRFTFND---------EIKTMKKFD 66 Query: 429 NPYIVRMIGICEAES-----WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMK 483 +P I+R+ GIC ++ + +VME ELG L + L + + + LV + + G+ Sbjct: 67 SPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLY 126 Query: 484 YLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APE 542 L S +HR++++ + L+ + K++ F LSK + K+ + Y +PE Sbjct: 127 RLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPE 186 Query: 543 CIN--YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAG--CP 598 + + + K++++SFG+++WE + G+ P+ G ++ ++ + ++ P G CP Sbjct: 187 RLKNPFCLYDIKAEIYSFGIVLWE-IATGKIPFEGCDSKKIRELVAEDKKQE-PVGQDCP 244 Query: 599 REMYDLMNLCWTYDVENRPGFAAVELRL 626 + +++N C ++ RP + RL Sbjct: 245 ELLREIINECRAHEPSQRPSVDGILERL 272 >3I6U-A nrPDB Length = 419 Score = 85.5 bits (210), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 65/213 (30%), Positives = 106/213 (49%), Gaps = 23/213 (10%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEA--------NDPALKDELLAEANVMQQ 426 K LGSG G VK + +K K VA++I+ DPAL E E ++++ Sbjct: 141 KTLGSGACGEVKLAF--ERKTCKKVAIRIISKRKFAIGSAREADPALNVE--TEIEILKK 196 Query: 427 LDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE 486 L++P I+++ +AE + +V+E+ E G L + N+ +K+ +Q+ + ++YL Sbjct: 197 LNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLH 256 Query: 487 ESNFVHRDLAARNVLLVTQH---YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPEC 543 E+ +HRDL NVLL +Q KI+DFG SK L +T P + APE Sbjct: 257 ENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS---LMRTLCGTPT-YLAPEV 312 Query: 544 ---INYYKFSSKSDVWSFGVLMWEAFSYGQKPY 573 + ++ D WS GV+++ S G P+ Sbjct: 313 LVSVGTAGYNRAVDCWSLGVILFICLS-GYPPF 344 >3LIJ-A nrPDB Length = 494 Score = 85.5 bits (210), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 69/220 (31%), Positives = 113/220 (51%), Gaps = 14/220 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K+LGSG +G V ++ V + A+KI++ + + +LL E V++ LD+P I++ Sbjct: 43 KKLGSGAYGEVLLCRDKVTHVER--AIKIIRKTSVSTSSNSKLLEEVAVLKLLDHPNIMK 100 Query: 435 MIGICEAE-SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + E + ++ LVME + G L + + + ++ QV G+ YL + N VHR Sbjct: 101 LYDFFEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHKHNIVHR 160 Query: 494 DLAARNVLLVTQH---YAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECINYYKF 549 DL N+LL ++ KI DFGLS EN K + + +Y APE + K+ Sbjct: 161 DLKPENLLLESKEKDALIKIVDFGLSAVF---ENQKKMKE--RLGTAYYIAPEVLR-KKY 214 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 K DVWS GV+++ + G P+ G E+ +EKG+ Sbjct: 215 DEKCDVWSIGVILFILLA-GYPPFGGQTDQEILRKVEKGK 253 >2XIK-A nrPDB Length = 294 Score = 84.7 bits (208), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 73/267 (27%), Positives = 119/267 (44%), Gaps = 23/267 (8%) Query: 353 ADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPA 412 DPEE+ K LDR +G G+FG V KG K V VA+KI+ + Sbjct: 15 VDPEELFTK---LDR---------IGKGSFGEVYKGIDNHTKEV--VAIKII-DLEEAED 59 Query: 413 LKDELLAEANVMQQLDNPYIVRMIG--ICEAESWMLVMEMAELGPLNKYLQQNRHVKDKN 470 +++ E V+ Q D+PYI R G + + W+++ + L+ L + +++ Sbjct: 60 EIEDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALD--LLKPGPLEETY 117 Query: 471 IIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQT 530 I ++ ++ G+ YL +HRD+ A NVLL Q K++DFG++ L + K T Sbjct: 118 IATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQL--TDTQIKRNT 175 Query: 531 HGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGER 590 P W APE I + K+D+WS G+ E + G+ P + V ++ K Sbjct: 176 FVGTPF-WMAPEVIKQSAYDFKADIWSLGITAIE-LAKGEPPNSDLHPMRVLFLIPKNSP 233 Query: 591 MGCPAGCPREMYDLMNLCWTYDVENRP 617 + + + C D RP Sbjct: 234 PTLEGQHSKPFKEFVEACLNKDPRFRP 260 >5HVK-A nrPDB Length = 315 Score = 84.7 bits (208), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 74/288 (25%), Positives = 119/288 (41%), Gaps = 38/288 (13%) Query: 359 RPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEAN-DPALKDEL 417 RP ++ L+ E LG G FG K ++ +T V ++K D + Sbjct: 6 RPHRIFRPSDLIHGE--VLGKGCFGQAIKVTHR-----ETGEVMVMKELIRFDEETQRTF 58 Query: 418 LAEANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQ-NRHVKDKNIIELV 475 L E VM+ L++P +++ IG+ + + + E + G L ++ + + Sbjct: 59 LKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFA 118 Query: 476 HQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWP 535 ++ GM YL N +HR+L + N L+ ++DFGL++ L DE K Q G Sbjct: 119 KDIASGMAYLHSMNIIHRNLNSHNCLVRENKNVVVADFGLAR-LMVDE---KTQPEGLRS 174 Query: 536 VK---------------WYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQK-----PYRG 575 +K W APE IN + K DV+SFG+++ E P Sbjct: 175 LKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTM 234 Query: 576 MKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVE 623 G V L++ CP CP + + C D E RP F +E Sbjct: 235 DFGLNVRGFLDR----YCPPNCPPSFFPITVRCCDLDPEKRPSFVKLE 278 >4BTF-A nrPDB Length = 469 Score = 84.3 bits (207), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 63/268 (23%), Positives = 127/268 (47%), Gaps = 28/268 (10%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTV-------AVKILKNEANDPALKDELLAEANVMQQLD 428 +L + T+ +G Y V V +V I++ ND E M++ D Sbjct: 202 KLKTSKMSTIYRGEYHRSPVTIKVFNNPQAESVGIVRFTFND---------EIKTMKKFD 252 Query: 429 NPYIVRMIGICEAES-----WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMK 483 +P I+R+ GIC ++ + +VME ELG L + L + + + LV + + G+ Sbjct: 253 SPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLY 312 Query: 484 YLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APE 542 L S +HR++++ + L+ + K++ F LSK + K+ + Y +PE Sbjct: 313 RLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPE 372 Query: 543 CIN--YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAG--CP 598 + + + K++++SFG+++WE + G+ P+ G ++ ++ + ++ P G CP Sbjct: 373 RLKNPFCLYDIKAEIYSFGIVLWE-IATGKIPFEGCDSKKIRELVAEDKKQE-PVGQDCP 430 Query: 599 REMYDLMNLCWTYDVENRPGFAAVELRL 626 + +++N C ++ RP + RL Sbjct: 431 ELLREIINECRAHEPSQRPSVDGILERL 458 >4RA4-A nrPDB Length = 355 Score = 84.3 bits (207), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 62/211 (29%), Positives = 101/211 (47%), Gaps = 15/211 (7%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE----LLAEANVMQQLDNPYI 432 LG G+FG V K + A+KILK D ++D+ + E V+ LD P Sbjct: 28 LGKGSFGKVMLA--DRKGTEELYAIKILKK---DVVIQDDDVECTMVEKRVLALLDKPPF 82 Query: 433 VRMIGIC--EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 + + C + VME G L ++QQ K+ + ++S+G+ +L + Sbjct: 83 LTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGI 142 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 ++RDL NV+L ++ + KI+DFG+ K D +T P + APE I Y + Sbjct: 143 IYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDG--VTTRTFCGTP-DYIAPEIIAYQPYG 199 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 D W++GVL++E + GQ P+ G E+ Sbjct: 200 KSVDWWAYGVLLYEMLA-GQPPFDGEDEDEL 229 >5YKS-A nrPDB Length = 377 Score = 84.3 bits (207), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 68/262 (25%), Positives = 118/262 (45%), Gaps = 28/262 (10%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 DK LG G+F VK + + VAVK++ D L E M+ + +P IV Sbjct: 40 DKTLGRGHFAVVKLARHVFTG--EKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIV 97 Query: 434 RMIGICEAESWM-LVMEMAELGPLNKYLQQ-----NRHVKDKNIIELVHQVSMGMKYLEE 487 R+ + + ++ + L++E+ + G + Y+ + N + K ++VH +S Y + Sbjct: 98 RLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAIS----YCHK 153 Query: 488 SNFVHRDLAARNVLLV-TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY 546 + VHRDL NV+ Q K++DFG S + K T + + APE + Sbjct: 154 LHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPG----KKLTTSCGSLAYSAPEILLG 209 Query: 547 YKFSSKS-DVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGC----PAGCPREM 601 ++ + + D+WS GV+++ GQ P++ SE M+ M C P+ +E Sbjct: 210 DEYDAPAVDIWSLGVILF-MLVCGQPPFQEANDSETLTMI-----MDCKYTVPSHVSKEC 263 Query: 602 YDLMNLCWTYDVENRPGFAAVE 623 DL+ D + R +E Sbjct: 264 KDLITRMLQRDPKRRASLEEIE 285 >5TOS-A nrPDB Length = 395 Score = 84.3 bits (207), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 66/210 (31%), Positives = 104/210 (49%), Gaps = 21/210 (10%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKT-------VAVKILKNEANDPALKDELLAEANVMQQ 426 D +G G FG V KG+ + T +AVK L E E L E N + Q Sbjct: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG--HREWLTEINYLGQ 127 Query: 427 LDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDKNI-----IELVHQVSM 480 L +P +V++IG C E E +LV E + G L +L + R K + + + + Sbjct: 128 LSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFR-RGAYFKPLPWFLRVNVALDAAK 186 Query: 481 GMKYLEES--NFVHRDLAARNVLLVTQHYAKISDFGLSK-ALRADENYYKAQTHGKWPVK 537 G+ +L ++RD+ A N+LL + AK+SDFGL++ D +Y + G + Sbjct: 187 GLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY--G 244 Query: 538 WYAPECINYYKFSSKSDVWSFGVLMWEAFS 567 + APE ++ +++SDV+SFGVL+ E S Sbjct: 245 YAAPEYMSSGHLNARSDVYSFGVLLLEILS 274 >4TPT-A nrPDB Length = 303 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 72/273 (26%), Positives = 113/273 (41%), Gaps = 37/273 (13%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEAN-DPALKDELLAEANVMQQLDNPYIVRM 435 LG G FG K ++ T V ++K D + L E VM+ LD+P +++ Sbjct: 8 LGKGFFGQAIKVTHK-----ATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKF 62 Query: 436 IGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRD 494 IG+ + + L+ E E G L +L+ + + ++ GM YL +HRD Sbjct: 63 IGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRD 122 Query: 495 LAARNVLLVTQHYAKISDFGLSKAL---RADENYYKAQTHGKWPVK-------------- 537 L + N L+ ++DFGLS+ + R KA T + K Sbjct: 123 LNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPY 182 Query: 538 WYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQK-------PYRGMKGSEVTAMLEKGER 590 W APE +N + D++SFG+++ E GQ P G V EK Sbjct: 183 WMAPEMLNGKSYDETVDIFSFGIVLCEII--GQVYADPDCLPRTLDFGLNVKLFWEK--- 237 Query: 591 MGCPAGCPREMYDLMNLCWTYDVENRPGFAAVE 623 P CP + L +C + E+RP F+ +E Sbjct: 238 -FVPTDCPPAFFPLAAICCRLEPESRPAFSKLE 269 >1FOT-A nrPDB Length = 318 Score = 82.8 bits (203), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 65/252 (25%), Positives = 120/252 (47%), Gaps = 24/252 (9%) Query: 375 KELGSGNFGTV-------KKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL 427 + LG+G+FG V YY MK + K + V++ + E + DE L ++ + Sbjct: 12 RTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTN----DERL----MLSIV 63 Query: 428 DNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE 486 +P+I+RM G +A+ ++M+ E G L L++++ + +V + ++YL Sbjct: 64 THPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLH 123 Query: 487 ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY 546 + ++RDL N+LL + KI+DFG +K + D Y T + APE ++ Sbjct: 124 SKDIIYRDLKPENILLDKNGHIKITDFGFAKYV-PDVTYTLCGTP-----DYIAPEVVST 177 Query: 547 YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMN 606 ++ D WSFG+L++E + G P+ + + E + P ++ DL++ Sbjct: 178 KPYNKSIDWWSFGILIYEMLA-GYTPFYDSNTMKTYEKILNAE-LRFPPFFNEDVKDLLS 235 Query: 607 LCWTYDVENRPG 618 T D+ R G Sbjct: 236 RLITRDLSQRLG 247 >3Q5I-A nrPDB Length = 504 Score = 82.4 bits (202), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 77/260 (29%), Positives = 126/260 (48%), Gaps = 26/260 (10%) Query: 375 KELGSGNFGTV-----KKGYYQMK-KVVKTVAV---KILKNEANDPALKDELLAEANVMQ 425 ++LGSG +G V K G+ + KV+K + + N +E+ E ++++ Sbjct: 42 RKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYNEISLLK 101 Query: 426 QLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDK-NIIELVHQVSMGMK 483 LD+P I+++ + E + + LV E E G L + + NRH D+ + ++ Q+ G+ Sbjct: 102 SLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQII-NRHKFDECDAANIMKQILSGIC 160 Query: 484 YLEESNFVHRDLAARNVLLVTQHY---AKISDFGLSKALRADENYYKAQTHGKWPVKWY- 539 YL + N VHRD+ N+LL ++ KI DFGLS D YK + + +Y Sbjct: 161 YLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKD---YKLRD--RLGTAYYI 215 Query: 540 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE---RMGCPAG 596 APE + K++ K DVWS GV+M+ G P+ G ++ +EKG+ Sbjct: 216 APEVLK-KKYNEKCDVWSCGVIMYILLC-GYPPFGGQNDQDIIKKVEKGKYYFDFNDWKN 273 Query: 597 CPREMYDLMNLCWTYDVENR 616 E +L+ L TYD R Sbjct: 274 ISDEAKELIKLMLTYDYNKR 293 >3IS5-A nrPDB Length = 285 Score = 81.6 bits (200), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 75/267 (28%), Positives = 129/267 (48%), Gaps = 27/267 (10%) Query: 370 LTLEDKELGSGNFG---TVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQ 426 L + ++LGSG FG V++ +++V+KT+ K+ + P +++ AE V++ Sbjct: 23 LFIFKRKLGSGAFGDVHLVEERSSGLERVIKTIN----KDRSQVPM--EQIEAEIEVLKS 76 Query: 427 LDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYL----QQNRHVKDKNIIELVHQVSMG 481 LD+P I+++ + E M +VME E G L + + + + + + + EL+ Q+ Sbjct: 77 LDHPNIIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNA 136 Query: 482 MKYLEESNFVHRDLAARNVLL--VTQHY-AKISDFGLSKALRADENYYKAQTHGKWPVKW 538 + Y + VH+DL N+L + H KI DFGL++ ++DE+ T+ + Sbjct: 137 LAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEH----STNAAGTALY 192 Query: 539 YAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV---TAMLEKGERMGCPA 595 APE + K D+WS GV+M+ + G P+ G EV E + C Sbjct: 193 MAPEVFK-RDVTFKCDIWSAGVVMYFLLT-GCLPFTGTSLEEVQQKATYKEPNYAVECRP 250 Query: 596 GCPREMYDLMNLCWTYDVENRPGFAAV 622 P+ + DL+ T D E RP A V Sbjct: 251 LTPQAV-DLLKQMLTKDPERRPSAAQV 276 >3DXN-A nrPDB Length = 287 Score = 81.6 bits (200), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 74/253 (29%), Positives = 117/253 (46%), Gaps = 22/253 (8%) Query: 375 KELGSGNFGTV---KKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPY 431 K+LGSG +G V K ++ +K + + +N AL DE+ V++QLD+P Sbjct: 27 KKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEV----AVLKQLDHPN 82 Query: 432 IVRMIGICEAE-SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 I+++ E + ++ LVME+ G L + + + + ++ QV G YL + N Sbjct: 83 IMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKHNI 142 Query: 491 VHRDLAARNVLLVTQH---YAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECINY 546 VHRDL N+LL ++ KI DFGLS + + +Y APE + Sbjct: 143 VHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVG-----GKMKERLGTAYYIAPEVLR- 196 Query: 547 YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP---AGCPREMYD 603 K+ K DVWS GV+++ G P+ G E+ +EKG+ P E Sbjct: 197 KKYDEKCDVWSCGVILYILLC-GYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQ 255 Query: 604 LMNLCWTYDVENR 616 L+ L TY+ R Sbjct: 256 LVKLMLTYEPSKR 268 >3T04-A nrPDB Length = 123 Score = 81.6 bits (200), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 41/99 (41%), Positives = 60/99 (60%), Gaps = 3/99 (3%) Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222 EK W+HG +SR +E L+ S NG FL+R +++ G ++ L +EG+V HYRI+ Sbjct: 14 EKHSWYHGPVSRNAAE--YLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 71 Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQK 261 GKL + +F+TL +LV H+S ADGL+ L P K Sbjct: 72 DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPK 110 Score = 48.9 bits (115), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 32/107 (29%), Positives = 58/107 (54%), Gaps = 7/107 (6%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74 ++ G ++R AE YL+ G+ +G +L+R+S + G ++S+ + + +HY I +G Sbjct: 18 WYHGPVSRNAAE-YLLSSGI-NGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKL 75 Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKPF---NRPQ--GVQPK 116 ++ + A+L H+HS +DGL+ L P N+P GV P Sbjct: 76 YVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPN 122 >3PFQ-A nrPDB Length = 674 Score = 81.3 bits (199), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 61/213 (28%), Positives = 102/213 (47%), Gaps = 19/213 (8%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE----LLAEANVMQQLDNPYI 432 LG G+FG V + K + AVKILK D ++D+ + E V+ P Sbjct: 349 LGKGSFGKVM--LSERKGTDELYAVKILKK---DVVIQDDDVECTMVEKRVLALPGKPPF 403 Query: 433 VRMIGIC--EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 + + C + VME G L ++QQ K+ + + ++++G+ +L+ Sbjct: 404 LTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGI 463 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKW--PVKWYAPECINYYK 548 ++RDL NV+L ++ + KI+DFG+ K EN + T + + APE I Y Sbjct: 464 IYRDLKLDNVMLDSEGHIKIADFGMCK-----ENIWDGVTTKTFCGTPDYIAPEIIAYQP 518 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 + D W+FGVL++E + GQ P+ G E+ Sbjct: 519 YGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDEL 550 >3DFA-A nrPDB Length = 286 Score = 81.3 bits (199), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 60/218 (27%), Positives = 109/218 (50%), Gaps = 14/218 (6%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 LG G+FG V K ++ + + AVK++ + +L E ++++LD+P I+++ Sbjct: 30 LGKGSFGEVLKCKDRITQ--QEYAVKVINKASAKNKDTSTILREVELLKKLDHPNIMKLF 87 Query: 437 GICE-AESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDL 495 I E + S+ +V E+ G L + + + + + ++ QV G+ Y+ + N VHRDL Sbjct: 88 EILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHNIVHRDL 147 Query: 496 AARNVLLVTQHY---AKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECINYYKFSS 551 N+LL ++ KI DFGLS + + + + +Y APE + + Sbjct: 148 KPENILLESKEKDCDIKIIDFGLSTCFQQN-----TKMKDRIGTAYYIAPEVLR-GTYDE 201 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 K DVWS GV+++ S G P+ G ++ +E G+ Sbjct: 202 KCDVWSAGVILYILLS-GTPPFYGKNEYDILKRVETGK 238 >2I0E-A nrPDB Length = 353 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 61/213 (28%), Positives = 102/213 (47%), Gaps = 19/213 (8%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE----LLAEANVMQQLDNPYI 432 LG G+FG V + K + AVKILK D ++D+ + E V+ P Sbjct: 28 LGKGSFGKVMLS--ERKGTDELYAVKILKK---DVVIQDDDVECTMVEKRVLALPGKPPF 82 Query: 433 VRMIGIC--EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 + + C + VME G L ++QQ K+ + + ++++G+ +L+ Sbjct: 83 LTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGI 142 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKW--PVKWYAPECINYYK 548 ++RDL NV+L ++ + KI+DFG+ K EN + T + + APE I Y Sbjct: 143 IYRDLKLDNVMLDSEGHIKIADFGMCK-----ENIWDGVTTKTFCGTPDYIAPEIIAYQP 197 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 + D W+FGVL++E + GQ P+ G E+ Sbjct: 198 YGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDEL 229 >4WNO-A nrPDB Length = 287 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 66/234 (28%), Positives = 112/234 (47%), Gaps = 19/234 (8%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G G F V KG ++ ++ VAVK + N+ N + L E ++++L + IV + Sbjct: 26 IGHGAFAVVFKGRHRAAHDLE-VAVKCI-NKKNLAKSQTLLGKEIKILKELKHENIVALY 83 Query: 437 GICE-AESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDL 495 E A S LVME G L YL R + + I + Q++ M+ L +HRDL Sbjct: 84 DFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDL 143 Query: 496 AARNVLLV---------TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY 546 +N+LL KI+DFG ++ L+++ A T P+ + APE I Sbjct: 144 KPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSN---MMAATLCGSPM-YMAPEVIMS 199 Query: 547 YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600 + K+D+WS G ++++ + G+ P++ ++ EK + + P PRE Sbjct: 200 QHYDGKADLWSIGTIVYQCLT-GKAPFQASSPQDLRLFYEKNKTL-VPT-IPRE 250 >3HZT-A nrPDB Length = 467 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 74/253 (29%), Positives = 117/253 (46%), Gaps = 22/253 (8%) Query: 375 KELGSGNFGTV---KKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPY 431 K+LGSG +G V K ++ +K + + +N AL DE+ V++QLD+P Sbjct: 10 KKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEV----AVLKQLDHPN 65 Query: 432 IVRMIGICEAE-SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 I+++ E + ++ LVME+ G L + + + + ++ QV G YL + N Sbjct: 66 IMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKHNI 125 Query: 491 VHRDLAARNVLLVTQH---YAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECINY 546 VHRDL N+LL ++ KI DFGLS + + +Y APE + Sbjct: 126 VHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVG-----GKMKERLGTAYYIAPEVLR- 179 Query: 547 YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP---AGCPREMYD 603 K+ K DVWS GV+++ G P+ G E+ +EKG+ P E Sbjct: 180 KKYDEKCDVWSCGVILYILLC-GYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQ 238 Query: 604 LMNLCWTYDVENR 616 L+ L TY+ R Sbjct: 239 LVKLMLTYEPSKR 251 >5XZW-A nrPDB Length = 471 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 75/272 (27%), Positives = 122/272 (44%), Gaps = 27/272 (9%) Query: 368 KLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL 427 K ++ D+ +G G F TVKK + KT AVKI+ + D + E V+Q+L Sbjct: 195 KDFSIIDEVVGQGAFATVKKAIERTTG--KTFAVKIISKRKVIGNM-DGVTRELEVLQKL 251 Query: 428 DNPYIVRMIGICE-AESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE 486 ++P IVR+ G E ES+ +VME G L ++ + V + E+ Q+ +KY+ Sbjct: 252 NHPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIH 311 Query: 487 ESNFVHRDLAARNVLLVTQH--YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 HRDL N+L+ KI+DFGL+K ++ + ++ K + + APE I Sbjct: 312 SMGISHRDLKPDNILIEQDDPVLVKITDFGLAK-VQGNGSFMKTFC---GTLAYVAPEVI 367 Query: 545 -------------NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERM 591 ++SS D+WS G L++ + G P+ G ++ + +G Sbjct: 368 RGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILT-GHLPFSGSTQDQLYKQIGRGSYH 426 Query: 592 GCPAGCPR---EMYDLMNLCWTYDVENRPGFA 620 P R E D ++ D NR A Sbjct: 427 EGPLKDFRISEEARDFIDSLLQVDPNNRSTAA 458 >3NCG-A nrPDB Length = 486 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 60/218 (27%), Positives = 109/218 (50%), Gaps = 14/218 (6%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 LG G+FG V K ++ + + AVK++ + +L E ++++LD+P I+++ Sbjct: 30 LGKGSFGEVLKCKDRITQ--QEYAVKVINKASAKNKDTSTILREVELLKKLDHPNIMKLF 87 Query: 437 GICE-AESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDL 495 I E + S+ +V E+ G L + + + + + ++ QV G+ Y+ + N VHRDL Sbjct: 88 EILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHNIVHRDL 147 Query: 496 AARNVLLVTQHY---AKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECINYYKFSS 551 N+LL ++ KI DFGLS + + + + +Y APE + + Sbjct: 148 KPENILLESKEKDCDIKIIDFGLSTCFQQN-----TKMKDRIGTAYYIAPEVLR-GTYDE 201 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 K DVWS GV+++ S G P+ G ++ +E G+ Sbjct: 202 KCDVWSAGVILYILLS-GTPPFYGKNEYDILKRVETGK 238 >4FZF-B nrPDB Length = 283 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 69/275 (25%), Positives = 121/275 (44%), Gaps = 39/275 (14%) Query: 353 ADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPA 412 ADPEE+ K L+R +G G+FG V KG + + VA+KI+ + Sbjct: 4 ADPEELFTK---LER---------IGKGSFGEVFKGIDN--RTQQVVAIKII-DLEEAED 48 Query: 413 LKDELLAEANVMQQLDNPYIVRMIG--ICEAESWMLV--------MEMAELGPLNKYLQQ 462 +++ E V+ Q D+ Y+ + G + ++ W+++ +++ GP +++ Sbjct: 49 EIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEF--- 105 Query: 463 NRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRAD 522 I ++ ++ G+ YL +HRD+ A NVLL Q K++ FG++ L Sbjct: 106 -------QIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLT-- 156 Query: 523 ENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVT 582 + K T P W APE I + SK+D+WS G+ E + G+ P M V Sbjct: 157 DTQIKRNTFVGTPF-WMAPEVIQQSAYDSKADIWSLGITAIE-LAKGEPPNSDMHPMRVL 214 Query: 583 AMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRP 617 ++ K + + ++ C D RP Sbjct: 215 FLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRP 249 >6QAU-A nrPDB Length = 280 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 67/234 (28%), Positives = 114/234 (48%), Gaps = 19/234 (8%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G G F V +G ++ +K VA+K + N+ N + L E ++++L + IV + Sbjct: 19 VGHGAFAVVFRGRHR-QKTDWEVAIKSI-NKKNLSKSQILLGKEIKILKELQHENIVALY 76 Query: 437 GICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDL 495 + E S LVME G L YLQ + + I +HQ++ M+ L +HRDL Sbjct: 77 DVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDL 136 Query: 496 AARNVLL---------VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY 546 +N+LL V+ KI+DFG ++ L + N A G P+ + APE I Sbjct: 137 KPQNILLSYANRRKSSVSGIRIKIADFGFARYLHS--NMMAADLCGS-PM-YMAPEVIMS 192 Query: 547 YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600 + +K+D+WS G ++++ G+ P++ ++ EK + P+ PRE Sbjct: 193 QHYDAKADLWSIGTVIYQCL-VGKPPFQANSPQDLRMFYEKNRSL-MPS-IPRE 243 >4MWI-A nrPDB Length = 294 Score = 80.1 bits (196), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 62/245 (25%), Positives = 119/245 (48%), Gaps = 16/245 (6%) Query: 399 VAVKILKN-EANDPAL-KDELLAEANVMQQLDNPYIVRMIGICEAES-----WMLVMEMA 451 VA+K+ K +A A+ + E M++ ++P I+R+ GIC E+ + +VME Sbjct: 50 VAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYC 109 Query: 452 ELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF--VHRDLAARNVLLVTQHYAK 509 ELG L + L + + + + LV + G+ L S +H + + N L+ + K Sbjct: 110 ELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVK 169 Query: 510 ISDFGLSKALRA-DENYYKAQTHGKWPVKWYAPECIN--YYKFSSKSDVWSFGVLMWEAF 566 ++ F L K + + +T + +P+ + +Y++ KS+++SFG+++WE Sbjct: 170 LAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWE-I 228 Query: 567 SYGQKPYRGMKGSEVTAMLEKGERMGCPAG--CPREMYDLMNLCWTYDVENRPGFAAVEL 624 + G P++G SE L +R P G CP E+ ++++ C +D RP + Sbjct: 229 ATGDIPFQGC-NSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILK 287 Query: 625 RLRNY 629 +L + Sbjct: 288 KLSTF 292 >6AMW-A nrPDB Length = 255 Score = 80.1 bits (196), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 41/99 (41%), Positives = 60/99 (60%), Gaps = 3/99 (3%) Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222 EK W+HG +SR +E L+ S NG FL+R +++ G ++ L +EG+V HYRI+ Sbjct: 142 EKHSWYHGPVSRNAAE--YLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 199 Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQK 261 GKL + +F+TL +LV H+S ADGL+ L P K Sbjct: 200 DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPK 238 Score = 49.3 bits (116), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 33/112 (29%), Positives = 60/112 (53%), Gaps = 7/112 (6%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74 ++ G ++R AE YL+ G+ +G +L+R+S + G ++S+ + + +HY I +G Sbjct: 146 WYHGPVSRNAAE-YLLSSGI-NGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKL 203 Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKPF---NRPQ--GVQPKTGPFE 121 ++ + A+L H+HS +DGL+ L P N+P GV P +E Sbjct: 204 YVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWE 255 >6CTH-A nrPDB Length = 309 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 59/199 (29%), Positives = 106/199 (53%), Gaps = 11/199 (5%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 + +LG G FG+V +G+ ++ +AVK + + A+ +K E +E ++ +L + +V Sbjct: 20 ENKLGEGGFGSVYRGF--LRDSDTYIAVKKV-SRASKQGIK-EYASEVKIISRLRHKNLV 75 Query: 434 RMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDKNI-IELVHQVSMGMKYLEESN-- 489 ++IG C E MLV E G L+ ++ + + + + +V ++ + YL E Sbjct: 76 KLIGWCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHEEGDH 135 Query: 490 -FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 +HRD+ N++L + AK+ DFGL++ + + K G V + APEC++ K Sbjct: 136 CVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAG--TVGYMAPECLSSGK 193 Query: 549 FSSKSDVWSFGVLMWEAFS 567 S +SDV+SFGV+ E S Sbjct: 194 ASKESDVYSFGVVALEIAS 212 >2ABL-A nrPDB Length = 163 Score = 79.3 bits (194), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 40/97 (41%), Positives = 59/97 (60%), Gaps = 3/97 (3%) Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222 EK W+HG +SR +E L+ S NG FL+R +++ G ++ L +EG+V HYRI+ Sbjct: 68 EKHSWYHGPVSRNAAE--YLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 125 Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPC 259 GKL + +F+TL +LV H+S ADGL+ L P Sbjct: 126 DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPA 162 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 27/92 (29%), Positives = 52/92 (56%), Gaps = 2/92 (2%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74 ++ G ++R AE YL+ G+ +G +L+R+S + G ++S+ + + +HY I +G Sbjct: 72 WYHGPVSRNAAE-YLLSSGI-NGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKL 129 Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKP 106 ++ + A+L H+HS +DGL+ L P Sbjct: 130 YVSSESRFNTLAELVHHHSTVADGLITTLHYP 161 >4REW-A nrPDB Length = 540 Score = 79.0 bits (193), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 60/200 (30%), Positives = 98/200 (49%), Gaps = 10/200 (5%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNPYIVRM 435 LG G FG VK G +++ VAVKIL + + + ++ E ++ +P+I+++ Sbjct: 14 LGVGTFGKVKVGKHELTG--HKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKL 71 Query: 436 IGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRD 494 + S +VME G L Y+ +N + +K L Q+ G+ Y VHRD Sbjct: 72 YQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRD 131 Query: 495 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS-KS 553 L NVLL AKI+DFGLS + +D + + + APE I+ ++ + Sbjct: 132 LKPENVLLDAHMNAKIADFGLSNMM-SDGEFLRTSCGSP---NYAAPEVISGRLYAGPEV 187 Query: 554 DVWSFGVLMWEAFSYGQKPY 573 D+WS GV+++ A G P+ Sbjct: 188 DIWSSGVILY-ALLCGTLPF 206 >5JN2-A nrPDB Length = 525 Score = 78.6 bits (192), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 64/219 (29%), Positives = 109/219 (49%), Gaps = 15/219 (6%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNPYIVRM 435 LG G+FG V + K + AVK++ K + K+ LL E +++QLD+P I+++ Sbjct: 75 LGKGSFGEVI--LCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKL 132 Query: 436 IGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRD 494 E + + LV E+ G L + + + + ++ QV G+ Y+ ++ VHRD Sbjct: 133 YEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRD 192 Query: 495 LAARNVLLVTQHY---AKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECINYYKFS 550 L N+LL ++ +I DFGLS A + + K +Y APE + + + Sbjct: 193 LKPENLLLESKSKDANIRIIDFGLSTHFEASK-----KMKDKIGTAYYIAPEVL-HGTYD 246 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 K DVWS GV+++ S G P+ G ++ +EKG+ Sbjct: 247 EKCDVWSTGVILYILLS-GCPPFNGANEYDILKKVEKGK 284 >4RED-A nrPDB Length = 351 Score = 78.6 bits (192), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 60/200 (30%), Positives = 98/200 (49%), Gaps = 10/200 (5%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNPYIVRM 435 LG G FG VK G +++ VAVKIL + + + ++ E ++ +P+I+++ Sbjct: 22 LGVGTFGKVKVGKHELTG--HAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKL 79 Query: 436 IGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRD 494 + S +VME G L Y+ +N + +K L Q+ G+ Y VHRD Sbjct: 80 YQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRD 139 Query: 495 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS-KS 553 L NVLL AKI+DFGLS + +D + + + APE I+ ++ + Sbjct: 140 LKPENVLLDAHMNAKIADFGLSNMM-SDGEFLRTSCGSP---NYAAPEVISGRLYAGPEV 195 Query: 554 DVWSFGVLMWEAFSYGQKPY 573 D+WS GV+++ A G P+ Sbjct: 196 DIWSSGVILY-ALLCGTLPF 214 >3MA6-A nrPDB Length = 298 Score = 78.6 bits (192), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 64/219 (29%), Positives = 109/219 (49%), Gaps = 15/219 (6%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNPYIVRM 435 LG G+FG V + K + AVK++ K + K+ LL E +++QLD+P I+++ Sbjct: 40 LGKGSFGEVI--LCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKL 97 Query: 436 IGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRD 494 E + + LV E+ G L + + + + ++ QV G+ Y+ ++ VHRD Sbjct: 98 YEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRD 157 Query: 495 LAARNVLLVTQHY---AKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECINYYKFS 550 L N+LL ++ +I DFGLS A + + K +Y APE + + + Sbjct: 158 LKPENLLLESKSKDANIRIIDFGLSTHFEASK-----KMKDKIGTAYYIAPEVL-HGTYD 211 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 K DVWS GV+++ S G P+ G ++ +EKG+ Sbjct: 212 EKCDVWSTGVILYILLS-GCPPFNGANEYDILKKVEKGK 249 >1S9I-A nrPDB Length = 354 Score = 78.6 bits (192), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 65/255 (25%), Positives = 125/255 (49%), Gaps = 16/255 (6%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 ELG+GN G V K ++ ++ +A K++ E PA++++++ E V+ + ++PYIV Sbjct: 23 ELGAGNGGVVTKVQHRPSGLI--MARKLIHLEIK-PAIRNQIIRELQVLHECNSPYIVGF 79 Query: 436 IGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN-FVHR 493 G ++ + + ME + G L++ L++ + + ++ + ++ V G+ YL E + +HR Sbjct: 80 YGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHR 139 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKS 553 D+ N+L+ ++ K+ DFG+S L T + APE + +S +S Sbjct: 140 DVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR-----SYMAPERLQGTHYSVQS 194 Query: 554 DVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK----GERMGCPAGCPREMYDLMNLCW 609 D+WS G+ + E + G+ P E+ A+ + GE G P Sbjct: 195 DIWSMGLSLVE-LAVGRYPIPPPDAKELEAIFGRPVVDGEE-GEPHSISPRPRPPGRPVS 252 Query: 610 TYDVENRPGFAAVEL 624 + +++RP A EL Sbjct: 253 GHGMDSRPAMAIFEL 267 >3NIZ-A nrPDB Length = 311 Score = 78.6 bits (192), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 52/196 (26%), Positives = 102/196 (52%), Gaps = 10/196 (5%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +++G G +G V K ++V A+K ++ +A D + + E +++++L +P IV Sbjct: 27 EKVGEGTYGVVYKAKDSQGRIV---ALKRIRLDAEDEGIPSTAIREISLLKELHHPNIVS 83 Query: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEESNFVH 492 +I + +E + LV E E L K L +N+ ++D I ++Q+ G+ + + +H Sbjct: 84 LIDVIHSERCLTLVFEFME-KDLKKVLDENKTGLQDSQIKIYLYQLLRGVAHCHQHRILH 142 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI-NYYKFSS 551 RDL +N+L+ + K++DFGL++A Y + W + AP+ + K+S+ Sbjct: 143 RDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLW---YRAPDVLMGSKKYST 199 Query: 552 KSDVWSFGVLMWEAFS 567 D+WS G + E + Sbjct: 200 SVDIWSIGCIFAEMIT 215 >3D2K-A nrPDB Length = 272 Score = 78.6 bits (192), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 66/258 (25%), Positives = 110/258 (42%), Gaps = 15/258 (5%) Query: 371 TLED----KELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQ 425 TLED + LG G FG V + K + +A+K+L K + ++ +L E + Sbjct: 10 TLEDFDIGRPLGKGKFGNVYLARERQSKFI--LALKVLFKTQLEKAGVEHQLRREVEIQS 67 Query: 426 QLDNPYIVRMIG-ICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKY 484 L +P I+R+ G +A L++E A LG + + LQ+ ++ + +++ + Y Sbjct: 68 HLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALSY 127 Query: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 +HRD+ N+LL + KI+DFG S + T + + PE I Sbjct: 128 CHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGT-----LDYLPPEMI 182 Query: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDL 604 K D+WS GVL +E F G P+ E + + E P DL Sbjct: 183 EGRMHDEKVDLWSLGVLCYE-FLVGMPPFEAHTYQETYRRISRVE-FTFPDFVTEGARDL 240 Query: 605 MNLCWTYDVENRPGFAAV 622 ++ ++ R A V Sbjct: 241 ISRLLKHNASQRLTLAEV 258 >4FR4-A nrPDB Length = 384 Score = 78.6 bits (192), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 64/244 (26%), Positives = 112/244 (45%), Gaps = 26/244 (10%) Query: 375 KELGSGNFGTV-------KKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL 427 + +G G+FG V K Y MK + K V+ +NE + + E +MQ L Sbjct: 21 RAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVE--RNEVRN------VFKELQIMQGL 72 Query: 428 DNPYIVRM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE 486 ++P++V + + E +V+++ G L +LQQN H K++ + + ++ M + YL+ Sbjct: 73 EHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQ 132 Query: 487 ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY 546 +HRD+ N+LL + I+DF ++ L + G P + APE + Sbjct: 133 NQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQI--TTMAGTKP--YMAPEMFSS 188 Query: 547 YK---FSSKSDVWSFGVLMWEAFSYGQKPY--RGMKGSEVTAMLEKGERMGCPAGCPREM 601 K +S D WS GV +E G++PY R S+ + + P+ +EM Sbjct: 189 RKGAGYSFAVDWWSLGVTAYELLR-GRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEM 247 Query: 602 YDLM 605 L+ Sbjct: 248 VSLL 251 >2WQN-A nrPDB Length = 310 Score = 78.2 bits (191), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 64/271 (23%), Positives = 126/271 (46%), Gaps = 27/271 (9%) Query: 374 DKELGSGNFGTVKKGYYQMKKV-VKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 +K++G G F V + + V V V+I + D + + + E ++++QL++P + Sbjct: 37 EKKIGRGQFSEVYRAACLLDGVPVALKKVQIF--DLMDAKARADCIKEIDLLKQLNHPNV 94 Query: 433 VRMIG-ICEAESWMLVMEMAELGPLNKYLQ----QNRHVKDKNIIELVHQVSMGMKYLEE 487 ++ E +V+E+A+ G L++ ++ Q R + ++ + + Q+ ++++ Sbjct: 95 IKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHS 154 Query: 488 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECINY 546 +HRD+ NV + K+ D GL + + H +Y +PE I+ Sbjct: 155 RRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSK----TTAAHSLVGTPYYMSPERIHE 210 Query: 547 YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPA----GCPREMY 602 ++ KSD+WS G L++E + Q P+ G K + + ++ +K E+ P E+ Sbjct: 211 NGYNFKSDIWSLGCLLYEMAAL-QSPFYGDKMN-LYSLCKKIEQCDYPPLPSDHYSEELR 268 Query: 603 DLMNLCWTYDVENRPGFAAVELRLRNYYYDV 633 L+N+C D E RP Y YDV Sbjct: 269 QLVNMCINPDPEKRPDV--------TYVYDV 291 >4CFH-A nrPDB Length = 493 Score = 78.2 bits (191), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 60/200 (30%), Positives = 98/200 (49%), Gaps = 10/200 (5%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNPYIVRM 435 LG G FG VK G +++ VAVKIL + + + ++ E ++ +P+I+++ Sbjct: 41 LGVGTFGKVKVGKHELTG--HKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKL 98 Query: 436 IGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRD 494 + S +VME G L Y+ +N + +K L Q+ G+ Y VHRD Sbjct: 99 YQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRD 158 Query: 495 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS-KS 553 L NVLL AKI+DFGLS + +D + + + APE I+ ++ + Sbjct: 159 LKPENVLLDAHMNAKIADFGLSNMM-SDGEFLRTSCGSP---NYAAPEVISGRLYAGPEV 214 Query: 554 DVWSFGVLMWEAFSYGQKPY 573 D+WS GV+++ A G P+ Sbjct: 215 DIWSSGVILY-ALLCGTLPF 233 >3DAK-A nrPDB Length = 290 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 76/278 (27%), Positives = 129/278 (46%), Gaps = 32/278 (11%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +GSG V+ Y KK + VA+K + E ++ DELL E M Q +P IV Sbjct: 18 IGSGATAVVQAAYCAPKK--EKVAIKRINLEKCQTSM-DELLKEIQAMSQCHHPNIVSYY 74 Query: 437 G--ICEAESWMLVMEM----AELGPLNKYLQQNRH----VKDKNIIELVHQVSMGMKYLE 486 + + E W LVM++ + L + + + H + + I ++ +V G++YL Sbjct: 75 TSFVVKDELW-LVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLH 133 Query: 487 ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKW---PVKWYAPEC 543 ++ +HRD+ A N+LL +I+DFG+S L + + + + P W APE Sbjct: 134 KNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPC-WMAPEV 192 Query: 544 INYYK-FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGC-PREM 601 + + + K+D+WSFG+ E + G PY +V + + + G +EM Sbjct: 193 MEQVRGYDFKADIWSFGITAIE-LATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEM 251 Query: 602 Y--------DLMNLCWTYDVENRPGFAAVELRLRNYYY 631 +++LC D E RP A EL LR+ ++ Sbjct: 252 LKKYGKSFRKMISLCLQKDPEKRP--TAAEL-LRHKFF 286 >2J90-A nrPDB Length = 304 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 54/210 (25%), Positives = 104/210 (49%), Gaps = 16/210 (7%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILK----NEANDPALKDELLAEANVMQQLDNP 430 +ELGSG F V+K + K K A K +K + + ++E+ E N+++++ +P Sbjct: 32 EELGSGQFAIVRK--CRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRHP 89 Query: 431 YIVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 I+ + I E ++ +L++E+ G L +L + + + + + Q+ G+ YL Sbjct: 90 NIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKR 149 Query: 490 FVHRDLAARNVLLVTQHY----AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 H DL N++L+ ++ K+ DFG++ + A + G ++ APE +N Sbjct: 150 IAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEF--KNIFG--TPEFVAPEIVN 205 Query: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPYRG 575 Y ++D+WS GV+ + S G P+ G Sbjct: 206 YEPLGLEADMWSIGVITYILLS-GASPFLG 234 >4L42-A nrPDB Length = 346 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 71/273 (26%), Positives = 124/273 (45%), Gaps = 27/273 (9%) Query: 355 PEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVV-----KTVAVKILKNEAN 409 PE+IRP+ L R L G G +G V +Q++KV K A+K+LK Sbjct: 12 PEKIRPECFELLRVL--------GKGGYGKV----FQVRKVTGANTGKIFAMKVLKKAMI 59 Query: 410 DPALKD--ELLAEANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHV 466 KD AE N+++++ +P+IV +I + + L++E G L L++ Sbjct: 60 VRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIF 119 Query: 467 KDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYY 526 + + ++SM + +L + ++RDL N++L Q + K++DFGL K D Sbjct: 120 MEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTV- 178 Query: 527 KAQTHGKW-PVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAML 585 TH +++ APE + + D WS G LM++ + G P+ G + + Sbjct: 179 ---THTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLT-GAPPFTGENRKKTIDKI 234 Query: 586 EKGERMGCPAGCPREMYDLMNLCWTYDVENRPG 618 K ++ P +E DL+ + +R G Sbjct: 235 LKC-KLNLPPYLTQEARDLLKKLLKRNAASRLG 266 >4PDS-A nrPDB Length = 347 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 72/268 (26%), Positives = 120/268 (44%), Gaps = 27/268 (10%) Query: 368 KLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL 427 K ++ D+ +G G F TVKK + KT +VKI+ + D + E V+Q+L Sbjct: 30 KDFSIIDEVVGQGAFATVKKAIE--RTTGKTFSVKIISKRKVIGNM-DGVTRELEVLQKL 86 Query: 428 DNPYIVRMIGICE-AESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE 486 ++P IVR+ G E ES+ +VME G L ++ + V + E+ Q+ +KY+ Sbjct: 87 NHPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIH 146 Query: 487 ESNFVHRDLAARNVLLVTQH--YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 HRDL N+L+ KI+ FGL+K ++ + ++ K + + APE I Sbjct: 147 SMGISHRDLKPDNILIEQDDPVLVKITAFGLAK-VQGNGSFMKTFC---GTLAYVAPEVI 202 Query: 545 -------------NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERM 591 ++SS D+WS G L++ + G P+ G ++ + +G Sbjct: 203 RGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILT-GHLPFSGSTQDQLYKQIGRGSYH 261 Query: 592 GCPAGCPR---EMYDLMNLCWTYDVENR 616 P R E D ++ D NR Sbjct: 262 EGPLKDFRISEEARDFIDSLLQVDPNNR 289 >3QA8-A nrPDB Length = 676 Score = 77.4 bits (189), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 61/210 (29%), Positives = 105/210 (50%), Gaps = 21/210 (10%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR-- 434 LG+G FG V + +Q + VA+K + E + P ++ E +M++L++P +V Sbjct: 22 LGTGGFGYVLRWIHQ--DTGEQVAIKQCRQELS-PKNRERWCLEIQIMKKLNHPNVVSAR 78 Query: 435 -----MIGICEAESWMLVMEMAELGPLNKYLQQNRH---VKDKNIIELVHQVSMGMKYLE 486 + + + +L ME E G L KYL Q + +K+ I L+ +S ++YL Sbjct: 79 EVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSALRYLH 138 Query: 487 ESNFVHRDLAARNVLLV---TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPEC 543 E+ +HRDL N++L + KI D G +K L D+ + G +++ APE Sbjct: 139 ENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKEL--DQGELCTEFVGT--LQYLAPEL 194 Query: 544 INYYKFSSKSDVWSFGVLMWEAFSYGQKPY 573 + K++ D WSFG L +E + G +P+ Sbjct: 195 LEQKKYTVTVDYWSFGTLAFECIT-GFRPF 223 >2XNP-A nrPDB Length = 279 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 63/258 (24%), Positives = 124/258 (48%), Gaps = 18/258 (6%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM- 435 +G+G++G +K + K K + K L + A K L++E N++++L +P IVR Sbjct: 14 IGTGSYGRCQK--IRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYY 71 Query: 436 --IGICEAESWMLVMEMAELGPL----NKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 I + +VME E G L K ++ +++ ++ ++ ++ Q+++ +K + Sbjct: 72 DRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRS 131 Query: 490 -----FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 +HRDL NV L + K+ DFGL++ L D ++ A+T P + +PE + Sbjct: 132 DGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSF--AKTFVGTPY-YMSPEQM 188 Query: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDL 604 N ++ KSD+WS G L++E + P+ E+ + +G+ P E+ ++ Sbjct: 189 NRMSYNEKSDIWSLGCLLYELCAL-MPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEI 247 Query: 605 MNLCWTYDVENRPGFAAV 622 + +RP + Sbjct: 248 ITRMLNLKDYHRPSVEEI 265 >4CFF-A nrPDB Length = 571 Score = 76.6 bits (187), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 58/200 (29%), Positives = 98/200 (49%), Gaps = 10/200 (5%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNPYIVRM 435 LG G FG VK G +Q+ VAVKIL + + + ++ E ++ +P+I+++ Sbjct: 41 LGVGTFGKVKIGEHQLTG--HKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 98 Query: 436 IGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRD 494 + + + +VME G L Y+ ++ V++ L Q+ + Y VHRD Sbjct: 99 YQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 158 Query: 495 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS-KS 553 L NVLL AKI+DFGLS + +D + + + APE I+ ++ + Sbjct: 159 LKPENVLLDAHMNAKIADFGLSNMM-SDGEFLRTSCGSP---NYAAPEVISGRLYAGPEV 214 Query: 554 DVWSFGVLMWEAFSYGQKPY 573 D+WS GV+++ A G P+ Sbjct: 215 DIWSCGVILY-ALLCGTLPF 233 >4AGU-A nrPDB Length = 311 Score = 76.6 bits (187), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 46/194 (23%), Positives = 93/194 (47%), Gaps = 7/194 (3%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 ++G G++G V K + + + VA+K +DP +K L E +++QL +P +V + Sbjct: 10 KIGEGSYGVVFKC--RNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNL 67 Query: 436 IGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRD 494 + + + + LV E + L++ + R V + + + Q + + + N +HRD Sbjct: 68 LEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRD 127 Query: 495 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE-CINYYKFSSKS 553 + N+L+ K+ DFG ++ L +YY + +W + +PE + ++ Sbjct: 128 VKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRW---YRSPELLVGDTQYGPPV 184 Query: 554 DVWSFGVLMWEAFS 567 DVW+ G + E S Sbjct: 185 DVWAIGCVFAELLS 198 >5O0Y-A nrPDB Length = 579 Score = 76.3 bits (186), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 57/173 (32%), Positives = 91/173 (52%), Gaps = 24/173 (13%) Query: 420 EANVMQQLDNPYIVRMIGI--CEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQ 477 E + ++LD+P IV++ + +S+ V+E E L+ YL+Q++ + +K ++ Q Sbjct: 338 EYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQ 397 Query: 478 VSMGMKYLEESN--FVHRDLAARNVLLVTQHYA---KISDFGLSKALRADENY------- 525 + +KYL E +H DL N+LLV KI+DFGLSK + D++Y Sbjct: 398 IVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIM-DDDSYNSVDGME 456 Query: 526 YKAQTHGKWPVKWY-APECINY----YKFSSKSDVWSFGVLMWEAFSYGQKPY 573 +Q G + WY PEC K S+K DVWS GV+ ++ YG+KP+ Sbjct: 457 LTSQGAGTY---WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCL-YGRKPF 505 >5EZV-A nrPDB Length = 560 Score = 76.3 bits (186), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 58/200 (29%), Positives = 98/200 (49%), Gaps = 10/200 (5%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNPYIVRM 435 LG G FG VK G +Q+ VAVKIL + + + ++ E ++ +P+I+++ Sbjct: 36 LGVGTFGKVKIGEHQLTG--HKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 93 Query: 436 IGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRD 494 + + + +VME G L Y+ ++ V++ L Q+ + Y VHRD Sbjct: 94 YQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 153 Query: 495 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS-KS 553 L NVLL AKI+DFGLS + +D + + + APE I+ ++ + Sbjct: 154 LKPENVLLDAHMNAKIADFGLSNMM-SDGEFLRTSCGSP---NYAAPEVISGRLYAGPEV 209 Query: 554 DVWSFGVLMWEAFSYGQKPY 573 D+WS GV+++ A G P+ Sbjct: 210 DIWSCGVILY-ALLCGTLPF 228 >2YAB-A nrPDB Length = 361 Score = 76.3 bits (186), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 57/218 (26%), Positives = 107/218 (49%), Gaps = 16/218 (7%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPA----LKDELLAEANVMQQLDNP 430 +ELGSG F VKK + K A K +K + + ++E+ E ++++Q+ +P Sbjct: 18 EELGSGQFAIVKKC--REKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVLHP 75 Query: 431 YIVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 I+ + + E + +L++E+ G L +L Q + ++ + Q+ G+ YL Sbjct: 76 NIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKK 135 Query: 490 FVHRDLAARNVLLVTQH----YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 H DL N++L+ ++ + K+ DFGL+ + E+ + + P ++ APE +N Sbjct: 136 IAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEI---EDGVEFKNIFGTP-EFVAPEIVN 191 Query: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTA 583 Y ++D+WS GV+ + S G P+ G E A Sbjct: 192 YEPLGLEADMWSIGVITYILLS-GASPFLGDTKQETLA 228 >3A8W-A nrPDB Length = 345 Score = 76.3 bits (186), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 62/219 (28%), Positives = 112/219 (51%), Gaps = 15/219 (6%) Query: 370 LTLEDKEL----GSGNFGTVKKGYYQMKKVVKTVAVKILKNE-ANDPALKDELLAEANVM 424 L L+D +L G G++ V ++KK + A+K++K E ND D + E +V Sbjct: 6 LGLQDFDLLRVIGRGSYAKVL--LVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVF 63 Query: 425 QQLDN-PYIVRMIGICEAESWML-VMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGM 482 +Q N P++V + + ES + V+E G L ++Q+ R + +++ ++S+ + Sbjct: 64 EQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLAL 123 Query: 483 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSK-ALRADENYYKAQTHGKWPVKWYAP 541 YL E ++RDL NVLL ++ + K++D+G+ K LR + T P + AP Sbjct: 124 NYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDT---TSTFCGTP-NYIAP 179 Query: 542 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSE 580 E + + D W+ GVLM+E + G+ P+ + S+ Sbjct: 180 EILRGEDYGFSVDWWALGVLMFEMMA-GRSPFDIVGSSD 217 >4KIK-B nrPDB Length = 677 Score = 76.3 bits (186), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 58/210 (27%), Positives = 105/210 (50%), Gaps = 21/210 (10%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR-- 434 LG+G FG V + + Q + + +A+K + E + P ++ E +M++L +P +V Sbjct: 27 LGTGGFGNVIRWHNQ--ETGEQIAIKQCRQELS-PRNRERWCLEIQIMRRLTHPNVVAAR 83 Query: 435 -----MIGICEAESWMLVMEMAELGPLNKYLQQNRH---VKDKNIIELVHQVSMGMKYLE 486 M + + +L ME + G L KYL Q + +++ I+ L+ ++ ++YL Sbjct: 84 DVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLH 143 Query: 487 ESNFVHRDLAARNVLLV---TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPEC 543 E+ +HRDL N++L + KI D G +K L D+ G +++ APE Sbjct: 144 ENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKEL--DQGSLCTSFVGT--LQYLAPEL 199 Query: 544 INYYKFSSKSDVWSFGVLMWEAFSYGQKPY 573 + K++ D WSFG L +E + G +P+ Sbjct: 200 LEQQKYTVTVDYWSFGTLAFECIT-GFRPF 228 >2X4F-A nrPDB Length = 373 Score = 76.3 bits (186), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 68/258 (26%), Positives = 127/258 (49%), Gaps = 26/258 (10%) Query: 334 KGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKK------ 387 K + AL +D +P+ D + K+ ++ + + LG G FG V K Sbjct: 55 KSKRTSALAVDIPAPPAPF-DHRIVTAKQGAVNSFYTVSKTEILGGGRFGQVHKCEETAT 113 Query: 388 GYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAES-WML 446 G K++KT +K K+E+ E +VM QLD+ ++++ E+++ +L Sbjct: 114 GLKLAAKIIKTRGMKD----------KEEVKNEISVMNQLDHANLIQLYDAFESKNDIVL 163 Query: 447 VMEMAELGPL-NKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQ 505 VME + G L ++ + ++ ++ + + I + Q+ G++++ + +H DL N+L V + Sbjct: 164 VMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNR 223 Query: 506 H--YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMW 563 KI DFGL++ + E K + + P ++ APE +NY S +D+WS GV+ + Sbjct: 224 DAKQIKIIDFGLARRYKPRE---KLKVNFGTP-EFLAPEVVNYDFVSFPTDMWSVGVIAY 279 Query: 564 EAFSYGQKPYRGMKGSEV 581 S G P+ G +E Sbjct: 280 MLLS-GLSPFLGDNDAET 296 >5FET-A nrPDB Length = 847 Score = 75.9 bits (185), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 68/265 (25%), Positives = 121/265 (45%), Gaps = 29/265 (10%) Query: 317 TVSFNPYEPELAPWAADKGPQREAL--PMDTEVYESPYADPEEIRPKEVYLDRKLLTLED 374 T S + W DK + + PM T + E ++ E+ +R + Sbjct: 487 TASIISKATSVECWFVDKSVFLQIIQGPMLTHLEERIKMQDTKVEMHELETERII----- 541 Query: 375 KELGSGNFGTVKKGYY---QMKKVVKTVAVK--ILKNEANDPALKDELLAEANVMQQLDN 429 G G FGTVK ++ Q++ +K V+ + I N+ N+ L+ E+ AE D+ Sbjct: 542 ---GRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAEN------DH 592 Query: 430 PYIVRMI-GICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 P+I+R++ ++ + + E+ G L +++ + + + + ++YL E Sbjct: 593 PFIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEYLHER 652 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 N V+RDL N+LL Q Y K+ DFG +K ++ +A T P + APE I Sbjct: 653 NIVYRDLKPENILLDKQGYVKLIDFGCAKKIQG-----RAYTLVGTP-HYMAPEVILGKG 706 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPY 573 + D+W+ GV ++E F G P+ Sbjct: 707 YGCTVDIWALGVCLYE-FICGPLPF 730 >4UZD-A nrPDB Length = 287 Score = 75.9 bits (185), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 66/257 (25%), Positives = 110/257 (42%), Gaps = 15/257 (5%) Query: 372 LEDKE----LGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQ 426 LED E LG G FG V + K + +A+K+L K + ++ +L E + Sbjct: 7 LEDFEIGRPLGKGKFGNVYLAREKQSKFI--LALKVLFKAQLEKAGVEHQLRREVEIQSH 64 Query: 427 LDNPYIVRMIG-ICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYL 485 L +P I+R+ G +A L++E A LG + + LQ+ ++ + +++ + Y Sbjct: 65 LRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYC 124 Query: 486 EESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 +HRD+ N+LL + KI+DFG S + T + + PE I Sbjct: 125 HSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGT-----LDYLPPEMIE 179 Query: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLM 605 K D+WS GVL +E F G+ P+ E + + E P DL+ Sbjct: 180 GRMHDEKVDLWSLGVLCYE-FLVGKPPFEANTYQETYKRISRVE-FTFPDFVTEGARDLI 237 Query: 606 NLCWTYDVENRPGFAAV 622 + ++ RP V Sbjct: 238 SRLLKHNPSQRPMLREV 254 >2YZA-A nrPDB Length = 276 Score = 75.5 bits (184), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 58/200 (29%), Positives = 98/200 (49%), Gaps = 10/200 (5%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNPYIVRM 435 LG G FG VK G +Q+ VAVKIL + + + ++ E ++ +P+I+++ Sbjct: 19 LGVGTFGKVKIGEHQLTG--HKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 76 Query: 436 IGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRD 494 + + + +VME G L Y+ ++ V++ L Q+ + Y VHRD Sbjct: 77 YQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRD 136 Query: 495 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS-KS 553 L NVLL AKI+DFGLS + +D + + + APE I+ ++ + Sbjct: 137 LKPENVLLDAHMNAKIADFGLSNMM-SDGEFLRDSCGSP---NYAAPEVISGRLYAGPEV 192 Query: 554 DVWSFGVLMWEAFSYGQKPY 573 D+WS GV+++ A G P+ Sbjct: 193 DIWSCGVILY-ALLCGTLPF 211 >4M66-A nrPDB Length = 325 Score = 75.5 bits (184), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 76/280 (27%), Positives = 123/280 (43%), Gaps = 34/280 (12%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G G FG V + +++ VAVKI+ ++ ++ E M L N ++ ++ Sbjct: 28 VGKGGFGVVFRAHHRTWN--HDVAVKIVNSK--------KISWEVKAMVNLRNENVLLLL 77 Query: 437 GICEAESW------MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN- 489 G+ E W LV E G L LQ + L+ +V +GM YL + Sbjct: 78 GVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGMCYLHSLDP 137 Query: 490 -FVHRDLAARNVLLVTQHYAKISDFGLSK---ALRADENYYKAQTHGKWPVKWYAPECI- 544 +HRDL N+LL + +AK++DFGLS ++ + + PE + Sbjct: 138 PLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDPELLF 197 Query: 545 -NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV-TAMLEKGER---MGCPAGCP- 598 K S SDV+SFG+L+W + G++ K S + + ++ R P G P Sbjct: 198 KVNLKASKASDVYSFGILVWAVLA-GREAELVDKTSLIRETVCDRQSRPPLTELPPGSPE 256 Query: 599 ----REMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVV 634 ++ +LM CW ENRP F E + N Y++V Sbjct: 257 TPGLEKLKELMIHCWGSQSENRPSFQDCEPK-TNEVYNLV 295 >4EQM-A nrPDB Length = 294 Score = 75.1 bits (183), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 56/208 (26%), Positives = 99/208 (47%), Gaps = 19/208 (9%) Query: 376 ELGSGNFGTV---KKGYYQMKKVVKTVAVKILKNEANDPALKDELLA----EANVMQQLD 428 +LG G TV + +K +K + + P K+E L E + QL Sbjct: 18 KLGGGGMSTVYLAEDTILNIKVAIKAIFIP--------PREKEETLKRFEREVHNSSQLS 69 Query: 429 NPYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 487 + IV MI + E + + LVME E L++Y++ + + I +Q+ G+K+ + Sbjct: 70 HQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDGIKHAHD 129 Query: 488 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY 547 VHRD+ +N+L+ + KI DFG++KAL E H V++++PE Sbjct: 130 MRIVHRDIKPQNILIDSNKTLKIFDFGIAKALS--ETSLTQTNHVLGTVQYFSPEQAKGE 187 Query: 548 KFSSKSDVWSFGVLMWEAFSYGQKPYRG 575 +D++S G++++E G+ P+ G Sbjct: 188 ATDECTDIYSIGIVLYEML-VGEPPFNG 214 >4BBM-A nrPDB Length = 331 Score = 75.1 bits (183), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 48/192 (25%), Positives = 91/192 (47%), Gaps = 7/192 (3%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G G++G V K + K + VA+K +D +K + E +++QL + +V ++ Sbjct: 33 VGEGSYGMVMKC--RNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLL 90 Query: 437 GICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDL 495 +C+ + W LV E + L+ + + + + + Q+ G+ + N +HRD+ Sbjct: 91 EVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDI 150 Query: 496 AARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE-CINYYKFSSKSD 554 N+L+ K+ DFG ++ L A Y + +W + APE + K+ D Sbjct: 151 KPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRW---YRAPELLVGDVKYGKAVD 207 Query: 555 VWSFGVLMWEAF 566 VW+ G L+ E F Sbjct: 208 VWAIGCLVTEMF 219 >5XD6-A nrPDB Length = 305 Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 68/246 (27%), Positives = 116/246 (47%), Gaps = 31/246 (12%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G G++G V +Y + K K A+K L + + P E LA+ +++ +L +V ++ Sbjct: 30 IGEGSYGRV---FYGILKSGKAAAIKKL-DSSKQP--DQEFLAQVSMVSRLRQENVVALL 83 Query: 437 GIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDKNI---------IELVHQVSMGMKYLE 486 G C + +L E A G L+ L + VK +++ + G++YL Sbjct: 84 GYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAARGLEYLH 143 Query: 487 ES---NFVHRDLAARNVLLVTQHYAKISDFGLS-KALRADENYYKAQTHGKWPVKWYAPE 542 E + +HRD+ + NVLL AKI+DF LS +A + + G + ++APE Sbjct: 144 EKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTF--GYHAPE 201 Query: 543 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 602 S+KSDV+SFGV++ E + G+KP V L +G++ P+ Sbjct: 202 YAMTGTLSTKSDVYSFGVVLLELLT-GRKP--------VDHTLPRGQQSVVTWATPKLSE 252 Query: 603 DLMNLC 608 D + C Sbjct: 253 DKVKQC 258 >3ORP-A nrPDB Length = 311 Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 49/186 (26%), Positives = 89/186 (47%), Gaps = 9/186 (4%) Query: 397 KTVAVKILKNE-ANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWM-----LVMEM 450 + VAVK+L+ + A DP+ EA L++P IV + EAE+ +VME Sbjct: 38 RDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEY 97 Query: 451 AELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKI 510 + L + + K IE++ + + ++ +HRD+ N+++ + K+ Sbjct: 98 VDGVTLRDIVHTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATNAVKV 157 Query: 511 SDFGLSKALRADENYYKAQTHGKWPVKWY-APECINYYKFSSKSDVWSFGVLMWEAFSYG 569 DFG+++A+ AD QT Y +PE ++SDV+S G +++E + G Sbjct: 158 MDFGIARAI-ADSGNSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLT-G 215 Query: 570 QKPYRG 575 + P+ G Sbjct: 216 EPPFTG 221 >4YNZ-A nrPDB Length = 342 Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 57/219 (26%), Positives = 108/219 (49%), Gaps = 12/219 (5%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 +K LG G G VK G + + + VA+KI+ E ++ ++ E +++ +++P+++ Sbjct: 15 EKTLGKGQTGLVKLGIHCV--TCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVL 72 Query: 434 RMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 ++ + E + ++ LV+E G L YL + + K + Q+ + + + H Sbjct: 73 KLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICH 132 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS- 551 RDL N+LL ++ +I+DFG++ D +T P + PE I K+ Sbjct: 133 RDLKPENLLLDERNNIRIADFGMASLQVGDS---LLETSCGSP-HYACPEVIRGEKYDGR 188 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGER 590 K+DVWS GV+++ A G P+ + +LEK +R Sbjct: 189 KADVWSCGVILF-ALLVGALPF---DDDNLRQLLEKVKR 223 >6HXF-B nrPDB Length = 302 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 60/259 (23%), Positives = 120/259 (46%), Gaps = 27/259 (10%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 ELG G FG V K + K+ A K+++ ++ + ++ + E ++ D+PYIV++ Sbjct: 26 ELGDGAFGKVYKA--KNKETGALAAAKVIETKSEEEL--EDYIVEIEILATCDHPYIVKL 81 Query: 436 IGIC--EAESWMLVMEMAELGPLNKY-LQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 +G + + W+++ E G ++ L+ +R + + I + Q+ + +L +H Sbjct: 82 LGAYYHDGKLWIMI-EFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIH 140 Query: 493 RDLAARNVLLVTQHYAKISDFGLS----KALRADENYYKAQTHGKWPVKWYAPECI---- 544 RDL A NVL+ + +++DFG+S K L+ +++ W APE + Sbjct: 141 RDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPY-------WMAPEVVMCET 193 Query: 545 -NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE--RMGCPAGCPREM 601 + K+D+WS G+ + E + + P+ + V + K + + P+ E Sbjct: 194 MKDTPYDYKADIWSLGITLIE-MAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEF 252 Query: 602 YDLMNLCWTYDVENRPGFA 620 D + + + E RP A Sbjct: 253 RDFLKIALDKNPETRPSAA 271 >4RLP-A nrPDB Length = 288 Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 64/251 (25%), Positives = 115/251 (45%), Gaps = 19/251 (7%) Query: 377 LGSGNFGTVKKGYYQMKKVV-----KTVAVKILKNEANDPALKD--ELLAEANVMQQLDN 429 LG G +G V +Q++KV K A+K+LK KD AE N+++++ + Sbjct: 13 LGKGGYGKV----FQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKH 68 Query: 430 PYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 P+IV +I + + L++E G L L++ + + ++SM + +L + Sbjct: 69 PFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQK 128 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKW-PVKWYAPECINYY 547 ++RDL N++L Q + K++DFGL K D TH +++ APE + Sbjct: 129 GIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTV----THTFCGTIEYMAPEILMRS 184 Query: 548 KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNL 607 + D WS G LM++ + G P+ G + + K ++ P +E DL+ Sbjct: 185 GHNRAVDWWSLGALMYDMLT-GAPPFTGENRKKTIDKILKC-KLNLPPYLTQEARDLLKK 242 Query: 608 CWTYDVENRPG 618 + +R G Sbjct: 243 LLKRNAASRLG 253 >4JXF-A nrPDB Length = 266 Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 59/202 (29%), Positives = 95/202 (47%), Gaps = 13/202 (6%) Query: 377 LGSGNFGTVKKGYYQMKKVVK--TVAVKILKNEANDPA-LKDELLAEANVMQQLDNPYIV 433 LG G+F G Y+ + + VA+K++ +A A + + E + QL +P I+ Sbjct: 15 LGKGSFA----GVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSIL 70 Query: 434 RMIGICEAESWM-LVMEMAELGPLNKYLQQN-RHVKDKNIIELVHQVSMGMKYLEESNFV 491 + E +++ LV+EM G +N+YL+ + + +HQ+ GM YL + Sbjct: 71 ELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGIL 130 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 HRDL N+LL KI+DFGL+ L+ K T P + +PE Sbjct: 131 HRDLTLSNLLLTRNMNIKIADFGLATQLKMPHE--KHYTLCGTP-NYISPEIATRSAHGL 187 Query: 552 KSDVWSFGVLMWEAFSYGQKPY 573 +SDVWS G M+ G+ P+ Sbjct: 188 ESDVWSLGC-MFYTLLIGRPPF 208 >5DYK-A nrPDB Length = 853 Score = 73.6 bits (179), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 57/205 (27%), Positives = 100/205 (48%), Gaps = 23/205 (11%) Query: 377 LGSGNFGTVK-------KGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDN 429 +G G FGTVK K Y +K V K + + N+ N+ L+ E+ AE D+ Sbjct: 547 IGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINL--NQQNNIKLEREITAEN------DH 598 Query: 430 PYIVRMI-GICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 P+I+R++ +++ + + E+ G L +++ + + + + ++YL E Sbjct: 599 PFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEYLHER 658 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 N V+RDL N+LL Q Y K+ DFG +K ++ +A T P + APE I Sbjct: 659 NIVYRDLKPENILLDKQGYVKLIDFGCAKKVQG-----RAYTLVGTP-HYMAPEVILGKG 712 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPY 573 + D+W+ G+ ++E F G P+ Sbjct: 713 YGCTVDIWALGICLYE-FICGPLPF 736 >5AR8-A nrPDB Length = 326 Score = 73.6 bits (179), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 74/274 (27%), Positives = 120/274 (43%), Gaps = 31/274 (11%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE---LLAEANVMQQLDNPYIV 433 L G GTV + +V VAVK L + P L E +L EA ++ + YI+ Sbjct: 40 LSRGASGTVSSARHADWRV--QVAVKHL--HIHTPLLDSERKDVLREAEILHKARFSYIL 95 Query: 434 RMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDKNI---IELVHQVSMGMKYLEESN 489 ++GIC E E +V E G LN+ L + D ++H++++G+ YL Sbjct: 96 PILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMT 155 Query: 490 --FVHRDLAARNVLLVTQHYAKISDFGLSK--ALRADENYYKAQTHGKWPVKWYAPECIN 545 +H DL +N+LL + + KI+DFGLSK + ++ + + PE N Sbjct: 156 PPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPE--N 213 Query: 546 Y-----YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGS-EVTAMLEKGER-----MGCP 594 Y + S K D++S+ V+ WE S Q P+ + ++ + +G R P Sbjct: 214 YEPGQKSRASIKHDIYSYAVITWEVLSRKQ-PFEDVTNPLQIMYSVSQGHRPVINEESLP 272 Query: 595 AGCPR--EMYDLMNLCWTYDVENRPGFAAVELRL 626 P M L+ W + + RP F + L Sbjct: 273 YDIPHRARMISLIESGWAQNPDERPSFLKCLIEL 306 >5KKR-C nrPDB Length = 395 Score = 72.8 bits (177), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 65/251 (25%), Positives = 123/251 (49%), Gaps = 12/251 (4%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 ELG+GN G V K ++ +V +A K++ E PA++++++ E V+ + ++PYIV Sbjct: 75 ELGAGNGGVVFKVSHKPSGLV--MARKLIHLEIK-PAIRNQIIRELQVLHECNSPYIVGF 131 Query: 436 IGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN-FVHR 493 G ++ + + ME + G L++ L++ + ++ + ++ V G+ YL E + +HR Sbjct: 132 YGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHR 191 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKS 553 D+ N+L+ ++ K+ DFG+S L T + +PE + +S +S Sbjct: 192 DVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR-----SYMSPERLQGTHYSVQS 246 Query: 554 DVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDV 613 D+WS G+ + E + G+ P E+ M + G A P +Y + Sbjct: 247 DIWSMGLSLVE-MAVGRYPIPPPDAKELELMF-GCQVEGDAAETPPRPRTPGRPLSSYGM 304 Query: 614 ENRPGFAAVEL 624 ++RP A EL Sbjct: 305 DSRPPMAIFEL 315 >4AN9-A nrPDB Length = 301 Score = 72.4 bits (176), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 54/199 (27%), Positives = 107/199 (53%), Gaps = 11/199 (5%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 ELG+GN G V K ++ +V +A K++ E PA++++++ E V+ + ++PYIV Sbjct: 16 ELGAGNGGVVFKVSHKPSGLV--MARKLIHLEIK-PAIRNQIIRELQVLHECNSPYIVGF 72 Query: 436 IGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN-FVHR 493 G ++ + + ME + G L++ L++ + ++ + ++ V G+ YL E + +HR Sbjct: 73 YGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHR 132 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKS 553 D+ N+L+ ++ K+ DFG+S L + T + +PE + +S +S Sbjct: 133 DVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTR-----SYMSPERLQGTHYSVQS 187 Query: 554 DVWSFGVLMWEAFSYGQKP 572 D+WS G+ + E + G+ P Sbjct: 188 DIWSMGLSLVE-MAVGRYP 205 >5DBX-A nrPDB Length = 328 Score = 72.0 bits (175), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 70/267 (26%), Positives = 120/267 (44%), Gaps = 29/267 (10%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +GSG V+ + ++ + VA+K + E ++ DELL E M Q +P +V Sbjct: 19 IGSGATAVVQAALCKPRQ--ERVAIKRINLEKCQTSM-DELLKEIQAMSQCSHPNVVTYY 75 Query: 437 G--ICEAESWMLVMEMAELGPL--------NKYLQQNRHVKDKNIIELVHQVSMGMKYLE 486 + + E W LVM++ G + N+ +N +++ I ++ +V G+ YL Sbjct: 76 TSFVVKDELW-LVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLH 134 Query: 487 ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKW---PVKWYAPEC 543 + +HRDL A N+LL +I+DFG+S L + + + + P W APE Sbjct: 135 RNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPC-WMAPEV 193 Query: 544 INYYK-FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGC-PREM 601 + + + K+D+WSFG+ E + G PY +V + + + G +EM Sbjct: 194 MEQVRGYDFKADMWSFGITAIE-LATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEM 252 Query: 602 Y--------DLMNLCWTYDVENRPGFA 620 L++LC D RP A Sbjct: 253 MKKYGKSFRKLLSLCLQKDPSKRPTAA 279 >3EQC-A nrPDB Length = 360 Score = 72.0 bits (175), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 56/212 (26%), Positives = 109/212 (51%), Gaps = 11/212 (5%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 ELG+GN G V K ++ +V +A K++ E PA++++++ E V+ + ++PYIV Sbjct: 40 ELGAGNGGVVFKVSHKPSGLV--MARKLIHLEIK-PAIRNQIIRELQVLHECNSPYIVGF 96 Query: 436 IGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN-FVHR 493 G ++ + + ME + G L++ L++ + ++ + ++ V G+ YL E + +HR Sbjct: 97 YGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHR 156 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKS 553 D+ N+L+ ++ K+ DFG+S L T + +PE + +S +S Sbjct: 157 DVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR-----SYMSPERLQGTHYSVQS 211 Query: 554 DVWSFGVLMWEAFSYGQKPYRGMKGSEVTAML 585 D+WS G+ + E + G+ P E+ M Sbjct: 212 DIWSMGLSLVE-MAVGRYPIPPPDAKELELMF 242 >5F9E-A nrPDB Length = 353 Score = 72.0 bits (175), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 71/261 (27%), Positives = 115/261 (44%), Gaps = 24/261 (9%) Query: 370 LTLED----KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE----LLAEA 421 L +ED K LG G+FG V + KK + A+K LK D L D+ + E Sbjct: 16 LKIEDFELHKMLGKGSFGKVFLA--EFKKTNQFFAIKALKK---DVVLMDDDVECTMVEK 70 Query: 422 NVMQ-QLDNPYIVRMIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVS 479 V+ ++P++ M + E+ VME G L ++Q ++ Sbjct: 71 RVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEII 130 Query: 480 MGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKW--PVK 537 +G+++L V+RDL N+LL + KI+DFG+ K EN ++ Sbjct: 131 LGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCK-----ENMLGDAKTNEFCGTPD 185 Query: 538 WYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGC 597 + APE + K++ D WSFGVL++E GQ P+ G E+ + + + P Sbjct: 186 YIAPEILLGQKYNHSVDWWSFGVLLYEML-IGQSPFHGQDEEELFHSI-RMDNPFYPRWL 243 Query: 598 PREMYDLMNLCWTYDVENRPG 618 +E DL+ + + E R G Sbjct: 244 EKEAKDLLVKLFVREPEKRLG 264 >1ZWS-A nrPDB Length = 288 Score = 72.0 bits (175), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 55/218 (25%), Positives = 106/218 (48%), Gaps = 16/218 (7%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALK----DELLAEANVMQQLDNP 430 +ELGSG F VKK + K A K +K + + + +E+ E ++++Q+ + Sbjct: 18 EELGSGQFAIVKKC--REKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHH 75 Query: 431 YIVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 ++ + + E + +L++E+ G L +L Q + ++ + Q+ G+ YL Sbjct: 76 NVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKK 135 Query: 490 FVHRDLAARNVLLVTQH----YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 H DL N++L+ ++ + K+ DFGL+ + E+ + + P ++ APE +N Sbjct: 136 IAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEI---EDGVEFKNIFGTP-EFVAPEIVN 191 Query: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTA 583 Y ++D+WS GV+ + S G P+ G E A Sbjct: 192 YEPLGLEADMWSIGVITYILLS-GASPFLGDTKQETLA 228 >5LPZ-A nrPDB Length = 332 Score = 71.6 bits (174), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 55/207 (26%), Positives = 103/207 (49%), Gaps = 15/207 (7%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 D +GSG FG V Y + K VA+K L + + E +AE + ++ + +V Sbjct: 22 DSLIGSGGFGDV---YKAILKDGSAVAIKKLIHVSGQG--DREFMAEMETIGKIKHRNLV 76 Query: 434 RMIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMG----MKYLEES 488 ++G C+ + +LV E + G L L + K ++++G + +L + Sbjct: 77 PLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHN 136 Query: 489 ---NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 + +HRD+ + NVLL A++SDFG+++ + A + + T P + PE Sbjct: 137 CSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTP-GYVPPEYYQ 195 Query: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKP 572 ++ S+K DV+S+GV++ E + G++P Sbjct: 196 SFRCSTKGDVYSYGVVLLELLT-GKRP 221 >2A27-A nrPDB Length = 321 Score = 71.6 bits (174), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 55/218 (25%), Positives = 106/218 (48%), Gaps = 16/218 (7%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALK----DELLAEANVMQQLDNP 430 +ELGSG F VKK + K A K +K + + + +E+ E ++++Q+ + Sbjct: 18 EELGSGQFAIVKKC--REKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHH 75 Query: 431 YIVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 ++ + + E + +L++E+ G L +L Q + ++ + Q+ G+ YL Sbjct: 76 NVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKK 135 Query: 490 FVHRDLAARNVLLVTQH----YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 H DL N++L+ ++ + K+ DFGL+ + E+ + + P ++ APE +N Sbjct: 136 IAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEI---EDGVEFKNIFGTP-EFVAPEIVN 191 Query: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTA 583 Y ++D+WS GV+ + S G P+ G E A Sbjct: 192 YEPLGLEADMWSIGVITYILLS-GASPFLGDTKQETLA 228 >5LPV-A nrPDB Length = 296 Score = 71.6 bits (174), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 55/207 (26%), Positives = 103/207 (49%), Gaps = 15/207 (7%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 D +GSG FG V Y + K VA+K L + + E +AE + ++ + +V Sbjct: 22 DSLIGSGGFGDV---YKAILKDGSAVAIKKLIHVSGQG--DREFMAEMETIGKIKHRNLV 76 Query: 434 RMIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMG----MKYLEES 488 ++G C+ + +LV E + G L L + K ++++G + +L + Sbjct: 77 PLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHN 136 Query: 489 ---NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 + +HRD+ + NVLL A++SDFG+++ + A + + T P + PE Sbjct: 137 CSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTP-GYVPPEYYQ 195 Query: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKP 572 ++ S+K DV+S+GV++ E + G++P Sbjct: 196 SFRCSTKGDVYSYGVVLLELLT-GKRP 221 >6GU6-A nrPDB Length = 302 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 54/226 (23%), Positives = 112/226 (49%), Gaps = 16/226 (7%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +++G G +G V KG + K + VA+K ++ E+ + + + E +++++L +P IV Sbjct: 13 EKIGEGTYGVVYKGRH--KTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVS 70 Query: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQ---NRHVKDKNIIELVHQVSMGMKYLEESNF 490 + + +S + L+ E + L KYL +++ + ++Q+ G+ + Sbjct: 71 LQDVLMQDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRV 129 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPEC-INYYKF 549 +HRDL +N+L+ + K++DFGL++A Y + W + +PE + ++ Sbjct: 130 LHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLW---YRSPEVLLGSARY 186 Query: 550 SSKSDVWSFGVLMWEAFSYGQKP-YRGMKGSEVTAMLEKGERMGCP 594 S+ D+WS G + E + +KP + G SE+ + +G P Sbjct: 187 STPVDIWSIGTIFAELAT--KKPLFHG--DSEIDQLFRIFRALGTP 228 >6BDL-A nrPDB Length = 347 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 62/218 (28%), Positives = 101/218 (46%), Gaps = 10/218 (4%) Query: 377 LGSGNFGTVKKGYYQMK-KVVKTVAVKILKNE-ANDPALKDELLAEANVMQQLDNPYIVR 434 LG G FG V+ Q+K + KT A+KILK D ++ + +E +MQ + +IVR Sbjct: 42 LGVGGFGRVE--LVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVR 99 Query: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + + ++ ++ME G L L+ +D V YL ++R Sbjct: 100 LYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYR 159 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKS 553 DL N++L + YAK+ DFG +K + + K T P ++ APE I + Sbjct: 160 DLKPENLILDHRGYAKLVDFGFAKKIGFGK---KTWTFCGTP-EYVAPEIILNKGHDISA 215 Query: 554 DVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERM 591 D WS G+LM+E + G P+ G + ++ +G M Sbjct: 216 DYWSLGILMYELLT-GSPPFSGPDPMKTYNIILRGIDM 252 >1G3N-A nrPDB Length = 326 Score = 70.9 bits (172), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 59/231 (25%), Positives = 111/231 (48%), Gaps = 22/231 (9%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLD---NPYI 432 E+G G +G V K +K + VA+K ++ + + + + E V++ L+ +P + Sbjct: 18 EIGEGAYGKVFKAR-DLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 Query: 433 VRMIGICEAE------SWMLVMEMAELGPLNKYLQQNRH--VKDKNIIELVHQVSMGMKY 484 VR+ +C LV E + L YL + V + I +++ Q+ G+ + Sbjct: 77 VRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF 135 Query: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 L VHRDL +N+L+ + K++DFGL++ ++ A T + + APE + Sbjct: 136 LHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY----SFQMALTSVVVTLWYRAPEVL 191 Query: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKP-YRGMKGSEVTAMLEKGERMGCP 594 +++ D+WS G + E F +KP +RG S+V + + + +G P Sbjct: 192 LQSSYATPVDLWSVGCIFAEMFR--RKPLFRG--SSDVDQLGKILDVIGLP 238 >4WB7-A nrPDB Length = 405 Score = 70.9 bits (172), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 59/252 (23%), Positives = 117/252 (46%), Gaps = 24/252 (9%) Query: 375 KELGSGNFGTV-------KKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL 427 K LG+G+FG V +Y MK + K VK+ + E L E ++Q + Sbjct: 102 KTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHT--------LNEKRILQAV 153 Query: 428 DNPYIVRM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE 486 + P++V++ + + +VME G + +L++ + + Q+ + +YL Sbjct: 154 NFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 213 Query: 487 ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY 546 + ++RDL N+L+ Q Y +++DFG +K ++ + T P ++ APE I Sbjct: 214 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG-----RTWTLCGTP-EYLAPEIILS 267 Query: 547 YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMN 606 ++ D W+ GVL++E + G P+ + ++ + G ++ P+ ++ DL+ Sbjct: 268 KGYNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLR 325 Query: 607 LCWTYDVENRPG 618 D+ R G Sbjct: 326 NLLQVDLTKRFG 337 >3KN6-A nrPDB Length = 325 Score = 70.9 bits (172), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 59/238 (24%), Positives = 108/238 (45%), Gaps = 35/238 (14%) Query: 370 LTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLD- 428 L L+DK LG G+F +K + KK + AVKI+ EAN +++ Sbjct: 12 LDLKDKPLGEGSFSICRKCVH--KKSNQAFAVKIISKRM-----------EANTQKEITA 58 Query: 429 ------NPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMG 481 +P IV++ + + LVME+ G L + +++ +H + ++ ++ Sbjct: 59 LKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSA 118 Query: 482 MKYLEESNFVHRDLAARNVLLVTQH---YAKISDFGLSKALRADENYYKAQTHGKWPVKW 538 + ++ + VHRDL N+L ++ KI DFG ++ D K + + + Sbjct: 119 VSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPC---FTLHY 175 Query: 539 YAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGS-------EVTAMLEKGE 589 APE +N + D+WS GV+++ S GQ P++ S E+ ++KG+ Sbjct: 176 AAPELLNQNGYDESCDLWSLGVILYTMLS-GQVPFQSHDRSLTCTSAVEIMKKIKKGD 232 >4AU8-A nrPDB Length = 296 Score = 70.9 bits (172), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 58/229 (25%), Positives = 113/229 (49%), Gaps = 15/229 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +++G G +GTV K + ++ + VA+K ++ + +D + L E ++++L + IVR Sbjct: 12 EKIGEGTYGTVFKA--KNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVR 69 Query: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIE-LVHQVSMGMKYLEESNFVH 492 + + ++ + LV E + L KY D I++ + Q+ G+ + N +H Sbjct: 70 LHDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 128 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK-FSS 551 RDL +N+L+ K++DFGL++A Y A+ W + P+ + K +S+ Sbjct: 129 RDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW---YRPPDVLFGAKLYST 185 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600 D+WS G + E + G+ + G++V L++ R+ G P E Sbjct: 186 SIDMWSAGCIFAELANAGRPLF---PGNDVDDQLKRIFRL---LGTPTE 228 >5X3F-B nrPDB Length = 393 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 63/269 (23%), Positives = 123/269 (45%), Gaps = 30/269 (11%) Query: 375 KELGSGNFGTV-------KKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL 427 K LG+G+FG V +Y MK + K VK+ + E L E ++Q + Sbjct: 90 KTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIE--------HTLNEKRILQAV 141 Query: 428 DNPYIVRM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE 486 + P++V++ + + +VME G + +L++ + + Q+ + +YL Sbjct: 142 NFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 201 Query: 487 ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY 546 + ++RDL N+L+ Q Y +++DFG +K ++ + T P ++ APE I Sbjct: 202 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG-----RTWTLCGTP-EYLAPEIILS 255 Query: 547 YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMN 606 ++ D W+ GVL++E + G P+ + ++ + G ++ P+ ++ DL+ Sbjct: 256 KGYNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLR 313 Query: 607 LCWTYDVENRPGFAAVELRLRNYYYDVVN 635 D+ R G L+N D+ N Sbjct: 314 NLLQVDLTKRFG------NLKNGVNDIKN 336 >3NIE-A nrPDB Length = 429 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 54/220 (24%), Positives = 101/220 (45%), Gaps = 32/220 (14%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G G++G V Y K K VA+K + D +L E ++ +L + YI+R+ Sbjct: 36 IGRGSYGYVYLAYD--KNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDYIIRLH 93 Query: 437 GICEAESWM------LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 + E + +V+E+A+ L K + + ++++ +++ + +G K++ ES Sbjct: 94 DLIIPEDLLKFDELYIVLEIAD-SDLKKLFKTPIFLTEQHVKTILYNLLLGEKFIHESGI 152 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYY---------------------KAQ 529 +HRDL N LL KI DFGL++ + +D++ + K Q Sbjct: 153 IHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPHNKNLKKQ 212 Query: 530 THGKWPVKWY-APECINYYK-FSSKSDVWSFGVLMWEAFS 567 +WY APE I + +++ D+WS G + E + Sbjct: 213 LTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLN 252 >5N23-A nrPDB Length = 352 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 62/269 (23%), Positives = 122/269 (45%), Gaps = 29/269 (10%) Query: 375 KELGSGNFGTV-------KKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL 427 + LG+G+FG V +Y MK + K VK+ + E L E + Q + Sbjct: 48 RTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHT--------LNEKRIQQAV 99 Query: 428 DNPYIVRM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE 486 + P++V++ + + +V+E A G + +L++ + + Q+ + +YL Sbjct: 100 NFPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159 Query: 487 ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY 546 + ++RDL N+L+ Q Y K++DFG +K ++ + T ++ APE I Sbjct: 160 SLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGRTPWTLCGTP-----EYLAPEIILS 214 Query: 547 YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMN 606 ++ D W+ GVL++E + G P+ + ++ + G ++ P+ ++ DL+ Sbjct: 215 KGYNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLR 272 Query: 607 LCWTYDVENRPGFAAVELRLRNYYYDVVN 635 D+ R G L+N D+ N Sbjct: 273 NLLQVDLTKRFG------NLKNGVNDIKN 295 >4RGJ-A nrPDB Length = 520 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 57/223 (25%), Positives = 107/223 (47%), Gaps = 18/223 (8%) Query: 375 KELGSGNFGTV---KKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPY 431 K LG G+FG V + + + +K ++ K +K + + K+ LL E +++ LD+ Sbjct: 66 KILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTD----KESLLREVELLKMLDHIN 121 Query: 432 IVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 I+++ E ++ LV ++ G L + + + + ++ Q+ G+ Y+ ++N Sbjct: 122 IMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMHKNNV 181 Query: 491 VHRDLAARNVLLVTQH----YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY 546 VHRDL N+LL T++ KI DFGLS Y + K +Y + + Sbjct: 182 VHRDLKPENILLETKNKEDMIIKIIDFGLSTHFE-----YSKKMKDKIGTAYYIAPDVLH 236 Query: 547 YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 + K D+WS GV+++ S G P+ G ++ +E G+ Sbjct: 237 GTYDEKCDIWSCGVILYILLS-GCPPFNGSNEYDILKKVEAGK 278 >3GUB-A nrPDB Length = 295 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 54/218 (24%), Positives = 103/218 (47%), Gaps = 16/218 (7%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALK----DELLAEANVMQQLDNP 430 +ELGSG F VKK + K A K +K + + +++ E ++++++ +P Sbjct: 17 EELGSGQFAVVKKC--REKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHP 74 Query: 431 YIVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 ++ + + E ++ +L+ E+ G L +L + + ++ E + Q+ G+ YL Sbjct: 75 NVITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQ 134 Query: 490 FVHRDLAARNVLLVTQHY----AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 H DL N++L+ ++ KI DFGL+ + + G ++ APE +N Sbjct: 135 IAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEF--KNIFGT--PEFVAPEIVN 190 Query: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTA 583 Y ++D+WS GV+ + S G P+ G E A Sbjct: 191 YEPLGLEADMWSIGVITYILLS-GASPFLGDTKQETLA 227 >5TQX-A nrPDB Length = 655 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 103/209 (49%), Gaps = 20/209 (9%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 LG+G FG V YQ +++ +A+K + E + ++ E +M++L++ +V+ Sbjct: 16 LGTGGFGNV--CLYQHRELDLKIAIKSCRLELSTKN-RERWCHEIQIMKKLNHANVVKAC 72 Query: 437 GICEA------ESWMLVMEMAELGPLNKYLQQNRH---VKDKNIIELVHQVSMGMKYLEE 487 + E + +L ME G L K L + + +K+ I+ L+ + G++YL E Sbjct: 73 DVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHE 132 Query: 488 SNFVHRDLAARNVLLVT---QHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 + +HRDL N++L + KI D G +K D + + T +++ APE Sbjct: 133 NKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAK----DVDQGELCTEFVGTLQYLAPELF 188 Query: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKPY 573 +++ D WSFG +++E + G +P+ Sbjct: 189 ENKPYTATVDYWSFGTMVFECIA-GYRPF 216 >3PG1-A nrPDB Length = 362 Score = 70.1 bits (170), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 59/205 (28%), Positives = 93/205 (45%), Gaps = 19/205 (9%) Query: 377 LGSGNFGTVKKGY------YQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNP 430 + SG++G V G +K+V TV+ N +D L +L E ++ +P Sbjct: 30 ISSGSYGAVCAGVDSEGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRLLNHFHHP 89 Query: 431 YIV--RMIGICEAESWM----LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKY 484 I+ R I + E M LV E+ Q + ++I ++ + +G+ Sbjct: 90 NILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQRIVISPQHIQYFMYHILLGLHV 149 Query: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APEC 543 L E+ VHRDL N+LL + I DF L++ AD N TH +WY APE Sbjct: 150 LHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTH-----RWYRAPEL 204 Query: 544 INYYK-FSSKSDVWSFGVLMWEAFS 567 + +K F+ D+WS G +M E F+ Sbjct: 205 VMQFKGFTKLVDMWSAGCVMAEMFN 229 >3LM0-A nrPDB Length = 327 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 105/218 (48%), Gaps = 16/218 (7%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDN-P 430 L KELG G F V++ K + A K LK + E+L E V++ + P Sbjct: 32 LTSKELGRGKFAVVRQCI--SKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCP 89 Query: 431 YIVRMIGICEAES-WMLVMEMAELGPLNKYL--QQNRHVKDKNIIELVHQVSMGMKYLEE 487 ++ + + E S +L++E A G + + V + ++I L+ Q+ G+ YL + Sbjct: 90 RVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQ 149 Query: 488 SNFVHRDLAARNVLLVTQH---YAKISDFGLSKAL-RADENYYKAQTHGKWPVKWYAPEC 543 +N VH DL +N+LL + + KI DFG+S+ + A E T ++ APE Sbjct: 150 NNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTP-----EYLAPEI 204 Query: 544 INYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 +NY ++ +D+W+ G++ + ++ P+ G E Sbjct: 205 LNYDPITTATDMWNIGIIAYMLLTH-TSPFVGEDNQET 241 >3ALO-A nrPDB Length = 327 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 72/262 (27%), Positives = 127/262 (48%), Gaps = 28/262 (10%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 E+G G +G+V K + K + +AVK +++ ++ K L+ VM+ D PYIV+ Sbjct: 29 EIGRGAYGSVNKMVH--KPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQF 86 Query: 436 IGIC--EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIE-LVHQVSMG----MKYLEES 488 G E + W + ME+ +K+ + V D I E ++ ++++ + +L+E+ Sbjct: 87 YGALFREGDCW-ICMELMSTS-FDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKEN 144 Query: 489 -NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN-- 545 +HRD+ N+LL K+ DFG+S L ++ K + G P + APE I+ Sbjct: 145 LKIIHRDIKPSNILLDRSGNIKLCDFGISGQLV--DSIAKTRDAGCRP--YMAPERIDPS 200 Query: 546 --YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKG--SEVTAMLEKGERMGCPAGCPRE- 600 + +SDVWS G+ ++E + G+ PY ++T ++ KG+ RE Sbjct: 201 ASRQGYDVRSDVWSLGITLYE-LATGRFPYPKWNSVFDQLTQVV-KGDPPQLSNSEEREF 258 Query: 601 ---MYDLMNLCWTYDVENRPGF 619 + +NLC T D RP + Sbjct: 259 SPSFINFVNLCLTKDESKRPKY 280 >3MN3-A nrPDB Length = 271 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 54/192 (28%), Positives = 96/192 (50%), Gaps = 10/192 (5%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNPYIV 433 K LG G+FG VK Y+ + VA+KI+ K ++ + E + ++ L +P+I+ Sbjct: 10 KTLGEGSFGKVKLAYHTTTG--QKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHII 67 Query: 434 RMIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 ++ + ++ + ++V+E A L Y+ Q + ++ Q+ ++Y VH Sbjct: 68 KLYDVIKSKDEIIMVIEYAG-NELFDYIVQRDKMSEQEARRFFQQIISAVEYCHRHKIVH 126 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS- 551 RDL N+LL KI+DFGLS + D N+ K + APE I+ ++ Sbjct: 127 RDLKPENLLLDEHLNVKIADFGLSNIM-TDGNFLKTSCGSP---NYAAPEVISGKLYAGP 182 Query: 552 KSDVWSFGVLMW 563 + DVWS GV+++ Sbjct: 183 EVDVWSCGVILY 194 >5IG1-A nrPDB Length = 344 Score = 69.7 bits (169), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 98/207 (47%), Gaps = 14/207 (6%) Query: 364 YLDRKLLTLEDKE--LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEA 421 + D + L+DK +G G F TV + K+ + AVK++ ++ + +++ E Sbjct: 10 FFDLYDVDLKDKRSVIGKGAFSTVHRCVN--KRTGEVCAVKVIALKSLRSSEINKIKREI 67 Query: 422 NVMQQLDNPYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM 480 + L + +IV M ES + LV E G L + + +K+ +HQ+ Sbjct: 68 GICSSLQHEHIVSMRRAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACMHQILS 127 Query: 481 GMKYLEESNFVHRDLAARNVLLVTQH---YAKISDFGLSKALRADENYYK-AQTHGKWPV 536 +++ N +HRDL N+LL ++ KI+DFGL+ + Y+ A T G Sbjct: 128 ALQHCHSKNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPG---- 183 Query: 537 KWYAPECINYYKFSSKSDVWSFGVLMW 563 + +PE I + + DVW+ GV+++ Sbjct: 184 -YLSPEVIRRVPYDTAVDVWACGVILY 209 >4D2V-A nrPDB Length = 356 Score = 69.7 bits (169), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 54/218 (24%), Positives = 102/218 (46%), Gaps = 14/218 (6%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNE---ANDPALKDELLAEANVMQQLDNPYIV 433 +G+G F VK + + + VA+KI+ ++ P +K E+ A N+ Q +I Sbjct: 37 IGTGGFAKVKLACHILTG--EMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQ----HIC 90 Query: 434 RMIGICE-AESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 ++ + E A +V+E G L Y+ + ++ + Q+ + Y+ + H Sbjct: 91 QLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAH 150 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF-SS 551 RDL N+L H K+ DFGL + +++Y+ G + + APE I + S Sbjct: 151 RDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCG--ALAYAAPELIQGKSYLGS 208 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 ++DVWS G+L++ G P+ + + A + +G+ Sbjct: 209 EADVWSMGILLY-VLMCGFLPFDDDTAAALVAKIMRGK 245 >2UV2-A nrPDB Length = 325 Score = 69.3 bits (168), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 61/251 (24%), Positives = 111/251 (44%), Gaps = 19/251 (7%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 ELG G FG V K Q K+ A K++ ++ + ++ + E +++ D+P IV++ Sbjct: 44 ELGDGAFGKVYKA--QNKETSVLAAAKVIDTKSEEEL--EDYMVEIDILASCDHPNIVKL 99 Query: 436 IGIC--EAESWMLVMEMAELGPLNKY-LQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 + E W+L+ E G ++ L+ R + + I + Q + YL ++ +H Sbjct: 100 LDAFYYENNLWILI-EFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIH 158 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK---- 548 RDL A N+L K++DFG+S + + + P W APE + Sbjct: 159 RDLKAGNILFTLDGDIKLADFGVSA--KNTRTIQRRDSFIGTPY-WMAPEVVMCETSKDR 215 Query: 549 -FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE--RMGCPAGCPREMYDLM 605 + K+DVWS G+ + E + + P+ + V + K E + P+ D + Sbjct: 216 PYDYKADVWSLGITLIE-MAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFL 274 Query: 606 NLCWTYDVENR 616 C +V+ R Sbjct: 275 KKCLEKNVDAR 285 >5UIU-A nrPDB Length = 323 Score = 69.3 bits (168), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 60/215 (27%), Positives = 101/215 (46%), Gaps = 24/215 (11%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKN--EANDPALKDELLAEAN 422 D + +++ ++G G FG V KGY TVAVK L + LK + E Sbjct: 43 FDERPISVGGNKMGEGGFGVVYKGYVNNT----TVAVKKLAAMVDITTEELKQQFDQEIK 98 Query: 423 VMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQ-------QNRHVKDKNIIEL 474 VM + + +V ++G + + LV G L L + H++ K + Sbjct: 99 VMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCK----I 154 Query: 475 VHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKW 534 + G+ +L E++ +HRD+ + N+LL AKISDFGL+ RA E + + + Sbjct: 155 AQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLA---RASEKFAQTVMTSRI 211 Query: 535 --PVKWYAPECINYYKFSSKSDVWSFGVLMWEAFS 567 + APE + + + KSD++SFGV++ E + Sbjct: 212 VGTTAYMAPEALR-GEITPKSDIYSFGVVLLEIIT 245 >5B2L-A nrPDB Length = 324 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 67/255 (26%), Positives = 115/255 (45%), Gaps = 19/255 (7%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 E+GSG G V K + +K +AVK ++ N K L+ V++ D PYIV+ Sbjct: 24 EMGSGTCGQVWK--MRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQC 81 Query: 436 IGICEAESWMLVMEMAELGPLNKYLQQNRH--VKDKNIIELVHQVSMGMKYLEESN-FVH 492 G + + + M +G + L++ + ++ + ++ + + YL+E + +H Sbjct: 82 FGTFITNTDVFI-AMELMGTSAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIH 140 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN-----YY 547 RD+ N+LL + K+ DFG+S L KA+T + APE I+ Sbjct: 141 RDVKPSNILLDERGQIKLCDFGISGRLVDS----KAKTRSAGCAAYMAPERIDPPDPTKP 196 Query: 548 KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGS-EVTAMLEKGERMGCPA--GCPREMYDL 604 + ++DVWS G+ + E + GQ PY+ K EV + + E P G + Sbjct: 197 DYDIRADVWSLGISLVE-LATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSF 255 Query: 605 MNLCWTYDVENRPGF 619 + C T D RP + Sbjct: 256 VKDCLTKDHRKRPKY 270 >4KS7-A nrPDB Length = 292 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 59/221 (26%), Positives = 102/221 (46%), Gaps = 14/221 (6%) Query: 366 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 425 D +LL ++G G+ G V + K + VAVK++ + ++ L E +M+ Sbjct: 20 DPRLLLDSYVKIGEGSTGIV--CLAREKHSGRQVAVKMM--DLRKQQRRELLFNEVVIMR 75 Query: 426 QLDNPYIVRMIG--ICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMK 483 + +V M + E W+L ME + G L + Q R + ++ I + V + Sbjct: 76 DYQHFNVVEMYKSYLVGEELWVL-MEFLQGGALTDIVSQVR-LNEEQIATVCEAVLQALA 133 Query: 484 YLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPEC 543 YL +HRD+ + ++LL K+SDFG + D K+ + W APE Sbjct: 134 YLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPY---WMAPEV 190 Query: 544 INYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAM 584 I+ ++++ D+WS G+++ E G+ PY S V AM Sbjct: 191 ISRSLYATEVDIWSLGIMVIEMVD-GEPPY--FSDSPVQAM 228 >4B8L-A nrPDB Length = 286 Score = 68.9 bits (167), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 53/214 (24%), Positives = 96/214 (44%), Gaps = 12/214 (5%) Query: 365 LDRKLLTLED----KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 420 + ++ T++D + LG G FG V + K + + V + K++ ++ +L E Sbjct: 7 MPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKV-LFKSQLEKEGVEHQLRRE 65 Query: 421 ANVMQQLDNPYIVRMIG-ICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVS 479 + L +P I+RM + + L++E A G L K LQ++ ++ + +++ Sbjct: 66 IEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELA 125 Query: 480 MGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY 539 + Y E +HRD+ N+L+ + KI+DFG S + T + + Sbjct: 126 DALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGT-----LDYL 180 Query: 540 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPY 573 PE I K D+W GVL +E F G P+ Sbjct: 181 PPEMIEGKTHDEKVDLWCAGVLCYE-FLVGMPPF 213 >2Y4I-B nrPDB Length = 319 Score = 68.9 bits (167), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 61/261 (23%), Positives = 112/261 (42%), Gaps = 23/261 (8%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G G FG V G + + ++ + ++ NE A K E++A +Q + +V + Sbjct: 41 IGKGRFGQVYHGRWHGEVAIRLIDIE-RDNEDQLKAFKREVMA----YRQTRHENVVLFM 95 Query: 437 GICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNII-ELVHQVSMGMKYLEESNFVHRD 494 G C + + ++ + + L ++ + V D N ++ ++ GM YL +H+D Sbjct: 96 GACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKD 155 Query: 495 LAARNVLLVTQHYAKISDFGL---SKALRADENYYKAQTHGKWPVKWYAPECI------- 544 L ++NV I+DFGL S L+A K + W APE I Sbjct: 156 LKSKNVFYDNGKVV-ITDFGLFSISGVLQAGRREDKLRIQNGWLCH-LAPEIIRQLSPDT 213 Query: 545 --NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP-AGCPREM 601 + FS SDV++ G + W + P++ + + G + G +E+ Sbjct: 214 EEDKLPFSKHSDVFALGTI-WYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEI 272 Query: 602 YDLMNLCWTYDVENRPGFAAV 622 D++ CW ++ E RP F + Sbjct: 273 SDILLFCWAFEQEERPTFTKL 293 >5NGU-A nrPDB Length = 381 Score = 68.9 bits (167), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 55/197 (27%), Positives = 95/197 (48%), Gaps = 10/197 (5%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G G +G V Y + KV VA+K + + + L E ++ + + I+ + Sbjct: 50 IGEGAYGMVCSAYDNLNKV--RVAIKKISPFEHQTYCQ-RTLREIKILLRFRHENIIGIN 106 Query: 437 GICEA---ESWMLVMEMAELGPLNKY-LQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 I A E V + +L + Y L + +H+ + +I ++Q+ G+KY+ +N +H Sbjct: 107 DIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLH 166 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APEC-INYYKFS 550 RDL N+LL T KI DFGL++ D ++ T +WY APE +N ++ Sbjct: 167 RDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTE-YVATRWYRAPEIMLNSKGYT 225 Query: 551 SKSDVWSFGVLMWEAFS 567 D+WS G ++ E S Sbjct: 226 KSIDIWSVGCILAEMLS 242 >2A1A-B nrPDB Length = 284 Score = 68.6 bits (166), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 99/207 (47%), Gaps = 31/207 (14%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +GSG FG V K +++ KT +K +K N+ A + E + +LD+ IV Sbjct: 19 IGSGGFGQVFKAKHRIDG--KTYVIKRVKYN-NEKAER-----EVKALAKLDHVNIVHYN 70 Query: 437 GI-----------------CEAESWMLVMEMAELGPLNKYLQQNRHVK-DKNI-IELVHQ 477 G + + + ME + G L +++++ R K DK + +EL Q Sbjct: 71 GCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQ 130 Query: 478 VSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVK 537 ++ G+ Y+ ++RDL N+ LV KI DFGL +L+ D +T K ++ Sbjct: 131 ITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKND----GKRTRSKGTLR 186 Query: 538 WYAPECINYYKFSSKSDVWSFGVLMWE 564 + +PE I+ + + D+++ G+++ E Sbjct: 187 YMSPEQISSQDYGKEVDLYALGLILAE 213 >3H4J-B nrPDB Length = 336 Score = 68.6 bits (166), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 56/202 (27%), Positives = 101/202 (50%), Gaps = 15/202 (7%) Query: 377 LGSGNFGTVKKGYY---QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 LG G+FG VK + Q K +K ++ ++LK +D ++ E E + ++ L +P+I+ Sbjct: 17 LGEGSFGKVKLATHYKTQQKVALKFISRQLLKK--SDMHMRVE--REISYLKLLRHPHII 72 Query: 434 RMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 ++ + + ++V+E A G L Y+ + + + + Q+ ++Y VH Sbjct: 73 KLYDVITTPTDIVMVIEYAG-GELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHRHKIVH 131 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS- 551 RDL N+LL KI+DFGLS + D N+ K + APE IN ++ Sbjct: 132 RDLKPENLLLDDNLNVKIADFGLSNIM-TDGNFLKTSCGSP---NYAAPEVINGKLYAGP 187 Query: 552 KSDVWSFGVLMWEAFSYGQKPY 573 + DVWS G++++ G+ P+ Sbjct: 188 EVDVWSCGIVLY-VMLVGRLPF 208 >2W4O-A nrPDB Length = 349 Score = 68.6 bits (166), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 103/211 (48%), Gaps = 15/211 (7%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 + ELG G V + + K K A+K+LK + ++ E+ V+ +L +P I+ Sbjct: 58 ESELGRGATSIVYRC--KQKGTQKPYALKVLKKTVDKKIVRTEI----GVLLRLSHPNII 111 Query: 434 RMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 ++ I E + + LV+E+ G L + + + +++ + V Q+ + YL E+ VH Sbjct: 112 KLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVH 171 Query: 493 RDLAARNVLLVT---QHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 RDL N+L T KI+DFGLSK + E+ +T P + APE + + Sbjct: 172 RDLKPENLLYATPAPDAPLKIADFGLSKIV---EHQVLMKTVCGTP-GYCAPEILRGCAY 227 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSE 580 + D+WS G++ + G +P+ +G + Sbjct: 228 GPEVDMWSVGIITYILLC-GFEPFYDERGDQ 257 >1U5R-A nrPDB Length = 348 Score = 68.6 bits (166), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 64/251 (25%), Positives = 115/251 (45%), Gaps = 20/251 (7%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALK-DELLAEANVMQQLDNPYIV 433 +E+G G+FG V + + + + VA+K + K +++ E +Q+L +P + Sbjct: 60 REIGHGSFGAVY--FARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTI 117 Query: 434 RMIG--ICEAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEESNF 490 + G + E +W LVME LG + L+ ++ +++ I + H G+ YL N Sbjct: 118 QYRGCYLREHTAW-LVMEYC-LGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNM 175 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI---NYY 547 +HRD+ A N+LL K+ DFG S ++ A N + + W APE I + Sbjct: 176 IHRDVKAGNILLSEPGLVKLGDFG-SASIMAPANSFVGTPY------WMAPEVILAMDEG 228 Query: 548 KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY-DLMN 606 ++ K DVWS G+ E + + P M + + E +G E + + ++ Sbjct: 229 QYDGKVDVWSLGITCIE-LAERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVD 287 Query: 607 LCWTYDVENRP 617 C ++RP Sbjct: 288 SCLQKIPQDRP 298 >6CMJ-A nrPDB Length = 321 Score = 68.2 bits (165), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 55/216 (25%), Positives = 106/216 (49%), Gaps = 19/216 (8%) Query: 371 TLEDKELGSGNFGTVK-------KGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANV 423 TL+D E+G G++G VK YY MK + K ++ +++ E + Sbjct: 37 TLKD-EIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEIAI 95 Query: 424 MQQLDNPYIVRMIGICE---AESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM 480 +++LD+P +V+++ + + + +V E+ GP+ + +D+ + Sbjct: 96 LKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYF-QDLIK 154 Query: 481 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540 G++YL +HRD+ N+L+ + KI+DFG+S + + + T G + A Sbjct: 155 GIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALL-SNTVGT--PAFMA 211 Query: 541 PECINYYK--FSSKS-DVWSFGVLMWEAFSYGQKPY 573 PE ++ + FS K+ DVW+ GV ++ F +GQ P+ Sbjct: 212 PESLSETRKIFSGKALDVWAMGVTLY-CFVFGQCPF 246 >3Q53-A nrPDB Length = 306 Score = 68.2 bits (165), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 62/252 (24%), Positives = 106/252 (42%), Gaps = 26/252 (10%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +++G G GTV Y V V I + K+ ++ E VM++ NP IV Sbjct: 27 EKIGQGASGTV----YTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKNPNIVN 82 Query: 435 MIG--ICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 + + E W +VME G L + + + + I + + +++L + +H Sbjct: 83 YLDSYLVGDELW-VVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALEFLHSNQVIH 140 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSK 552 RD+ + N+LL K++DFG + +++ K T P W APE + + K Sbjct: 141 RDIKSDNILLGMDGSVKLTDFGFCAQITPEQS--KRSTMVGTPY-WMAPEVVTRKAYGPK 197 Query: 553 SDVWSFGVLMWEAFSYGQKPYRG--------MKGSEVTAMLEKGERMGCPAGCPREMYDL 604 D+WS G++ E G+ PY + + T L+ E++ D Sbjct: 198 VDIWSLGIMAIEMIE-GEPPYLNENPLRALYLIATNGTPELQNPEKLSAI------FRDF 250 Query: 605 MNLCWTYDVENR 616 +N C DVE R Sbjct: 251 LNRCLEMDVEKR 262 >4KRC-A nrPDB Length = 317 Score = 68.2 bits (165), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 58/229 (25%), Positives = 112/229 (48%), Gaps = 20/229 (8%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 ++LG+G + TV KG + V + L +E P+ + E ++M++L + IVR Sbjct: 11 EKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTA---IREISLMKELKHENIVR 67 Query: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDK------NIIELVH-QVSMGMKYLE 486 + + E+ + LV E + L KY+ +R V + N+++ Q+ G+ + Sbjct: 68 LYDVIHTENKLTLVFEFMD-NDLKKYMD-SRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 Query: 487 ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI-N 545 E+ +HRDL +N+L+ + K+ DFGL++A N + ++ W + AP+ + Sbjct: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLW---YRAPDVLMG 182 Query: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP 594 +S+ D+WS G ++ E + G+ + G E ++ + MG P Sbjct: 183 SRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI--FDIMGTP 228 >2F57-A nrPDB Length = 317 Score = 68.2 bits (165), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 53/200 (26%), Positives = 91/200 (45%), Gaps = 12/200 (6%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 ++G G+ G V K K VAVK K + ++ L E +M+ + +V M Sbjct: 52 KIGEGSTGIV--CIATEKHTGKQVAVK--KMDLRKQQRRELLFNEVVIMRDYHHDNVVDM 107 Query: 436 IG--ICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + E W +VME E G L + R + ++ I + V + YL +HR Sbjct: 108 YSSYLVGDELW-VVMEFLEGGALTDIVTHTR-MNEEQIATVCLSVLRALSYLHNQGVIHR 165 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKS 553 D+ + ++LL + K+SDFG + + K+ + W APE I+ + ++ Sbjct: 166 DIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPY---WMAPEVISRLPYGTEV 222 Query: 554 DVWSFGVLMWEAFSYGQKPY 573 D+WS G+++ E G+ PY Sbjct: 223 DIWSLGIMVIEMID-GEPPY 241 >1KOB-A nrPDB Length = 387 Score = 68.2 bits (165), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 63/225 (28%), Positives = 107/225 (47%), Gaps = 17/225 (7%) Query: 355 PEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALK 414 P E++ VY +L +ELGSG FG V + ++K V V N P K Sbjct: 41 PVEVKQGSVYDYYDIL----EELGSGAFGVVHRC---VEKATGRVFVAKFINTPY-PLDK 92 Query: 415 DELLAEANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPL-NKYLQQNRHVKDKNII 472 + E ++M QL +P ++ + E + M L++E G L ++ ++ + + +I Sbjct: 93 YTVKNEISIMNQLHHPKLINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVI 152 Query: 473 ELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA--KISDFGLSKALRADENYYKAQT 530 + Q G+K++ E + VH D+ N++ T+ + KI DFGL+ L DE K T Sbjct: 153 NYMRQACEGLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDE-IVKVTT 211 Query: 531 HGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG 575 ++ APE ++ +D+W+ GVL + S G P+ G Sbjct: 212 AT---AEFAAPEIVDREPVGFYTDMWAIGVLGYVLLS-GLSPFAG 252 >2BPM-A nrPDB Length = 309 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 48/197 (24%), Positives = 98/197 (49%), Gaps = 10/197 (5%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +++G G +G V K ++ V VA+K ++ + + + E +++++L++P IV+ Sbjct: 13 EKIGEGTYGVVYKARNKLTGEV--VALKKIRLDTETEGVPSTAIREISLLKELNHPNIVK 70 Query: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQN--RHVKDKNIIELVHQVSMGMKYLEESNFV 491 ++ + E+ + LV E L K++ + + I + Q+ G+ + + Sbjct: 71 LLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 129 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK-FS 550 HRDL +N+L+ T+ K++DFGL++A Y + W + APE + K +S Sbjct: 130 HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLW---YRAPEILLGCKYYS 186 Query: 551 SKSDVWSFGVLMWEAFS 567 + D+WS G + E + Sbjct: 187 TAVDIWSLGCIFAEMVT 203 >3RP9-A nrPDB Length = 458 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 52/222 (23%), Positives = 104/222 (46%), Gaps = 34/222 (15%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G+G++G V + Y +++K + VA+K + D +L E ++ +L++ ++V+++ Sbjct: 61 IGTGSYGHVCEAYDKLEK--RVVAIKKILRVFEDLIDCKRILREIAILNRLNHDHVVKVL 118 Query: 437 GIC------EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 I + + +V+E+A+ K + ++ + +I L++ + +G+KY+ + Sbjct: 119 DIVIPKDVEKFDELYVVLEIAD-SDFKKLFRTPVYLTELHIKTLLYNLLVGVKYVHSAGI 177 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADEN-----------------------YYK 527 +HRDL N L+ K+ DFGL++ + EN K Sbjct: 178 LHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVTFPHTKNLK 237 Query: 528 AQTHGKWPVKWY-APECINYYK-FSSKSDVWSFGVLMWEAFS 567 Q G +WY APE I + ++ DVWS G + E + Sbjct: 238 RQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLN 279 >4CZT-A nrPDB Length = 464 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 59/226 (26%), Positives = 103/226 (45%), Gaps = 14/226 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLA----EANVMQQLDNP 430 + LG G F VK + + + VA+K++ E LK++++A E + M+ + +P Sbjct: 17 RTLGEGTFAKVK--FARNVENGDNVAIKVIDKE---KVLKNKMIAQIKREISTMKLIKHP 71 Query: 431 YIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 ++RM + +++ + V+E G L + N +K+ + Q+ + Y Sbjct: 72 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRG 131 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 HRDL N+LL K+SDFGLS + T P + APE IN + Sbjct: 132 VYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP-NYVAPEVINNKGY 190 Query: 550 S-SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP 594 +K+D+WS GV+++ G P+ + + + K E CP Sbjct: 191 DGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKIFKAE-FTCP 234 >3N9X-A nrPDB Length = 432 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 54/220 (24%), Positives = 100/220 (45%), Gaps = 29/220 (13%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G G++G V Y K K VA+K + D +L E ++ +L + YI+R+ Sbjct: 34 IGRGSYGYVYLAY--DKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDYIIRLY 91 Query: 437 GICEAESWM------LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 + + + +V+E+A+ L K + + +++I +++ + +G ++ ES Sbjct: 92 DLIIPDDLLKFDELYIVLEIAD-SDLKKLFKTPIFLTEEHIKTILYNLLLGENFIHESGI 150 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENY------------------YKAQTHG 532 +HRDL N LL K+ DFGL++ + ++++ K Q Sbjct: 151 IHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKNLKKQLTS 210 Query: 533 KWPVKWY-APECINYYKFSSKS-DVWSFGVLMWEAFSYGQ 570 +WY APE I + +KS D+WS G + E + Q Sbjct: 211 HVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQ 250 >3HDN-A nrPDB Length = 373 Score = 67.8 bits (164), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 56/213 (26%), Positives = 104/213 (48%), Gaps = 15/213 (7%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE----LLAEANVM-QQLDN 429 K +G G+FG V ++ ++V AVK+L+ +A LK + +++E NV+ + + + Sbjct: 44 KVIGKGSFGKVLLARHKAEEVF--YAVKVLQKKA---ILKKKEEKHIMSERNVLLKNVKH 98 Query: 430 PYIVRM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 P++V + A+ V++ G L +LQ+ R + +++ + YL Sbjct: 99 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 158 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 N V+RDL N+LL +Q + ++DFGL K E+ T P ++ APE ++ Sbjct: 159 NIVYRDLKPENILLDSQGHIVLTDFGLCK--ENIEHNSTTSTFCGTP-EYLAPEVLHKQP 215 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 + D W G +++E YG P+ +E+ Sbjct: 216 YDRTVDWWCLGAVLYEML-YGLPPFYSRNTAEM 247 >2GCD-A nrPDB Length = 309 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 64/251 (25%), Positives = 115/251 (45%), Gaps = 20/251 (7%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALK-DELLAEANVMQQLDNPYIV 433 +E+G G+FG V + + + + VA+K + K +++ E +Q+L +P + Sbjct: 21 REIGHGSFGAVY--FARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTI 78 Query: 434 RMIG--ICEAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEESNF 490 + G + E +W LVME LG + L+ ++ +++ I + H G+ YL N Sbjct: 79 QYRGCYLREHTAW-LVMEYC-LGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNM 136 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI---NYY 547 +HRD+ A N+LL K+ DFG S ++ A N + + W APE I + Sbjct: 137 IHRDVKAGNILLSEPGLVKLGDFG-SASIMAPANSFVGTPY------WMAPEVILAMDEG 189 Query: 548 KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY-DLMN 606 ++ K DVWS G+ E + + P M + + E +G E + + ++ Sbjct: 190 QYDGKVDVWSLGITCIE-LAERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVD 248 Query: 607 LCWTYDVENRP 617 C ++RP Sbjct: 249 SCLQKIPQDRP 259 >3UIU-A nrPDB Length = 306 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 41/157 (26%), Positives = 79/157 (50%), Gaps = 11/157 (7%) Query: 410 DPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVK-D 468 DP D+ L ++ +P + + + + ME + G L +++++ R K D Sbjct: 80 DPETSDDSLESSDY-----DPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLD 134 Query: 469 KNI-IELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYK 527 K + +EL Q++ G+ Y+ +HRDL N+ LV KI DFGL +L+ D Sbjct: 135 KVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKND----G 190 Query: 528 AQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWE 564 +T K +++ +PE I+ + + D+++ G+++ E Sbjct: 191 KRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE 227 >5Z33-A nrPDB Length = 425 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 56/221 (25%), Positives = 98/221 (44%), Gaps = 15/221 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLD---NPY 431 KELG G +G V + + VA+K + N + L L E ++Q N Sbjct: 37 KELGQGAYGIVCAAVN--NQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGHRNIT 94 Query: 432 IVRMIGICEAESW---MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 + + I +++ L E+ E L ++ + + D + ++Q+ G+KY+ + Sbjct: 95 CLYDMDIPRPDNFNETYLYEELMECD-LAAIIRSGQPLTDAHFQSFIYQILCGLKYIHSA 153 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APEC-INY 546 N +HRDL N+L+ KI DFGL++ D +WY APE +++ Sbjct: 154 NVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAPEIMLSF 213 Query: 547 YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 ++ DVWS G ++ E G +P+ KG + L + Sbjct: 214 QSYTKAIDVWSVGCILAELL--GGRPF--FKGRDYVDQLNQ 250 >4CQG-A nrPDB Length = 331 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 48/192 (25%), Positives = 96/192 (50%), Gaps = 13/192 (6%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEA---NDPALKDELLAEANVMQQLDNPYIV 433 +G+G F VK + + + VA+KI+ A + P +K E+ + ++ L + +I Sbjct: 17 IGTGGFAKVKLACHVLTG--EMVAIKIMDKNALGSDLPRVKTEI----DALKSLRHQHIC 70 Query: 434 RMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 ++ + E ++ + +V+E G L Y+ + ++ + Q+ + Y+ + H Sbjct: 71 QLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQGYAH 130 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF-SS 551 RDL N+L H K+ DFGL + +++Y+ + G + + APE I + S Sbjct: 131 RDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGS--LAYAAPELIQGKSYLGS 188 Query: 552 KSDVWSFGVLMW 563 ++DVWS G+L++ Sbjct: 189 EADVWSMGILLY 200 >5EFQ-A nrPDB Length = 347 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 60/244 (24%), Positives = 113/244 (46%), Gaps = 23/244 (9%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G G +G V K + K + VA+K ++ + + E +++QL + I+ M Sbjct: 19 IGEGTYGQVYKA--RDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMK 76 Query: 437 GICEAE-----------SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYL 485 I + ++ LV E + + H + +I + Q+ G+ Y Sbjct: 77 EIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYC 136 Query: 486 EESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE--C 543 + NF+HRD+ N+LL + K++DFGL++ ++E+ + T+ K WY P Sbjct: 137 HKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEES--RPYTN-KVITLWYRPPELL 193 Query: 544 INYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYD 603 + +++ DVWS G ++ E F+ +KP + ++ A LE R+ C + CP D Sbjct: 194 LGEERYTPAIDVWSCGCILGELFT--KKPI--FQANQELAQLELISRI-CGSPCPAVWPD 248 Query: 604 LMNL 607 ++ L Sbjct: 249 VIKL 252 >6FD3-A nrPDB Length = 300 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 61/252 (24%), Positives = 105/252 (41%), Gaps = 26/252 (10%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +++G G GTV Y + V I + K+ ++ E VM++ NP IV Sbjct: 28 EKIGQGASGTV----YTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVN 83 Query: 435 MIG--ICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 + + E W +VME G L + + + + I + + + +L + +H Sbjct: 84 YLDSYLVGDELW-VVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQVIH 141 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSK 552 RD+ + N+LL K++DFG + +++ K T P W APE + + K Sbjct: 142 RDIKSDNILLGMDGSVKLTDFGFCAQITPEQS--KRSTMVGTPY-WMAPEVVTRKAYGPK 198 Query: 553 SDVWSFGVLMWEAFSYGQKPYRG--------MKGSEVTAMLEKGERMGCPAGCPREMYDL 604 D+WS G++ E G+ PY + + T L+ ER+ D Sbjct: 199 VDIWSLGIMAIEMVE-GEPPYLNENPLRALYLIATNGTPELQNPERLSAV------FRDF 251 Query: 605 MNLCWTYDVENR 616 +N C DV+ R Sbjct: 252 LNRCLEMDVDRR 263 >3DB8-A nrPDB Length = 317 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 61/253 (24%), Positives = 109/253 (43%), Gaps = 25/253 (9%) Query: 350 SPYADPEEIRPKE---VYLDRKLLT--LEDKELGSGNFGTV-------KKGYYQMKKVVK 397 S + DP+ KE V +D + + + + LG G F K + K V K Sbjct: 18 SAHVDPKSAPLKEIPDVLVDPRTMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPK 77 Query: 398 TVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPL 456 ++ +K P K+++ E + + LDNP++V G E + ++ +V+E+ L Sbjct: 78 SMLLK--------PHQKEKMSTEIAIHKSLDNPHVVGFHGFFEDDDFVYVVLEICRRRSL 129 Query: 457 NKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLS 516 + ++ + V + + Q G++YL + +HRDL N+ L KI DFGL+ Sbjct: 130 LELHKRRKAVTEPEARYFMRQTIQGVQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLA 189 Query: 517 KALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGM 576 + D K + APE + S + D+WS G +++ G+ P+ Sbjct: 190 TKIEFDGERKKDLCGTP---NYIAPEVLCKKGHSFEVDIWSLGCILYTLL-VGKPPFETS 245 Query: 577 KGSEVTAMLEKGE 589 E ++K E Sbjct: 246 CLKETYIRIKKNE 258 >3ORZ-A nrPDB Length = 316 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 50/203 (24%), Positives = 94/203 (46%), Gaps = 6/203 (2%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLA-EANVMQQLDNPYIV 433 K LG G+F TV + + A+KIL+ K + E +VM +LD+P+ V Sbjct: 43 KILGEGSFSTVVLA--RELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFV 100 Query: 434 RM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 ++ + E + A+ G L KY+++ + ++ ++YL +H Sbjct: 101 KLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIH 160 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSK 552 RDL N+LL + +I+DFG +K L + +A + ++ +PE + Sbjct: 161 RDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSF-VGTAQYVSPELLTEKSACKS 219 Query: 553 SDVWSFGVLMWEAFSYGQKPYRG 575 SD+W+ G ++++ + G P+R Sbjct: 220 SDLWALGCIIYQLVA-GLPPFRA 241 >4FIE-A nrPDB Length = 423 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 68/271 (25%), Positives = 114/271 (42%), Gaps = 32/271 (11%) Query: 308 PAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPY---ADPEEIRPKEVY 364 P RQE+ + P P + PQRE + E + + DP + R Y Sbjct: 104 PPARARQENGMPEKPPGP--------RSPQREPQRVSHEQFRAALQLVVDPGDPR---SY 152 Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424 LD + ++G G+ G V ++ K VAVK K + ++ L E +M Sbjct: 153 LDNFI------KIGEGSTGIV--CIATVRSSGKLVAVK--KMDLRKQQRRELLFNEVVIM 202 Query: 425 QQLDNPYIVRMIG--ICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGM 482 + + +V M + E W +VME E G L + R + ++ I + V + Sbjct: 203 RDYQHENVVEMYNSYLVGDELW-VVMEFLEGGALTDIVTHTR-MNEEQIAAVCLAVLQAL 260 Query: 483 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 542 L +HRD+ + ++LL K+SDFG + + K+ + W APE Sbjct: 261 SVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY---WMAPE 317 Query: 543 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPY 573 I+ + + D+WS G+++ E G+ PY Sbjct: 318 LISRLPYGPEVDIWSLGIMVIEMVD-GEPPY 347 >4JG6-A nrPDB Length = 355 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 46/204 (22%), Positives = 96/204 (47%), Gaps = 16/204 (7%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +++G G++ K+ ++ + AVKI+ DP + E+L ++ +P I+ Sbjct: 41 EDIGVGSYSVCKRCIHKATNM--EFAVKIIDKSKRDPTEEIEIL-----LRYGQHPNIIT 93 Query: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + + + ++ +V E+ + G L + + + ++ ++ ++ ++YL VHR Sbjct: 94 LKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHR 153 Query: 494 DLAARNVLLVTQ----HYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 DL N+L V + +I DFG +K LRA+ + + APE + + Sbjct: 154 DLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPC---YTANFVAPEVLERQGY 210 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPY 573 + D+WS GVL++ + G P+ Sbjct: 211 DAACDIWSLGVLLYTMLT-GYTPF 233 >4OTD-A nrPDB Length = 341 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 67/228 (29%), Positives = 109/228 (47%), Gaps = 20/228 (8%) Query: 365 LDRKLLTLEDKE----LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE---L 417 L + LTLED + LG G+FG V + + + A+K LK D +DE L Sbjct: 4 LRKSPLTLEDFKFLAVLGRGHFGKVLLS--EFRPSGELFAIKALKK--GDIVARDEVESL 59 Query: 418 LAEANVMQQLDN---PYIVRMIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIE 473 + E ++ + + P++V + G + E VME + G L ++ + + + I Sbjct: 60 MCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIF- 118 Query: 474 LVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGK 533 V +G+++L E V+RDL N+LL T+ Y KI+DFGL K + + T Sbjct: 119 YSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGD--RTSTFCG 176 Query: 534 WPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 P ++ APE + ++ D W GVL++E G+ P+ G EV Sbjct: 177 TP-EFLAPEVLTDTSYTRAVDWWGLGVLLYEML-VGESPFPGDDEEEV 222 >4JDH-A nrPDB Length = 346 Score = 66.6 bits (161), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 71/282 (25%), Positives = 120/282 (42%), Gaps = 34/282 (12%) Query: 299 PKPGHRKSSPAQGNR--QESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPY---A 353 P+ H ++ QG R QE+ + P P + PQRE + E + + Sbjct: 16 PRGSHMENLYFQGARARQENGMPEKPPGP--------RSPQREPQRVSHEQFRAALQLVV 67 Query: 354 DPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPAL 413 DP + R YLD + ++G G+ G V ++ K VAVK K + Sbjct: 68 DPGDPR---SYLDNFI------KIGEGSTGIV--CIATVRSSGKLVAVK--KMDLRKQQR 114 Query: 414 KDELLAEANVMQQLDNPYIVRMIG--ICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNI 471 ++ L E +M+ + +V M + E W +VME E G L + R + ++ I Sbjct: 115 RELLFNEVVIMRDYQHENVVEMYNSYLVGDELW-VVMEFLEGGALTDIVTHTR-MNEEQI 172 Query: 472 IELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTH 531 + V + L +HRD+ + ++LL K+SDFG + + K+ Sbjct: 173 AAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVG 232 Query: 532 GKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPY 573 + W APE I+ + + D+WS G+++ E G+ PY Sbjct: 233 TPY---WMAPELISRLPYGPEVDIWSLGIMVIEMVD-GEPPY 270 >5LOH-A nrPDB Length = 341 Score = 66.2 bits (160), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 55/204 (26%), Positives = 96/204 (47%), Gaps = 10/204 (4%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKN-EANDPALKDELLAEANVMQQLDNPYIV 433 K + G FG V Y +K K AVK++K + + + ++ AE + + +P+IV Sbjct: 42 KPISRGAFGKV----YLGQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIV 97 Query: 434 RMI-GICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 + + A + LVME G + L + ++ ++ + +V++ + YL +H Sbjct: 98 HLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIH 157 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKA-LRADENYYKAQTHGKW--PVKWYAPECINYYKF 549 RDL N+L+ + + K++DFGLSK L D N T + + APE + Sbjct: 158 RDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPELLLGRAH 217 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPY 573 D W+ GV ++E F G P+ Sbjct: 218 GPAVDWWALGVCLFE-FLTGIPPF 240 >3ZDU-A nrPDB Length = 325 Score = 66.2 bits (160), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 45/191 (23%), Positives = 92/191 (48%), Gaps = 8/191 (4%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 ++G G++GTV K + K + VA+KI E + ++ + E ++Q + +V + Sbjct: 10 KVGEGSYGTVMKCKH--KNTGQIVAIKIF-YERPEQSVNKIAMREIKFLKQFHHENLVNL 66 Query: 436 IGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRD 494 I + + + LV E + L++ ++ K + + + Q+ + YL +N +HRD Sbjct: 67 IEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNIIHRD 126 Query: 495 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI-NYYKFSSKS 553 + N+L+ K+ DFG ++ L A + Y + +W + APE + + Sbjct: 127 IKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRW---YRAPELVLKDTSYGKPV 183 Query: 554 DVWSFGVLMWE 564 D+W+ G ++ E Sbjct: 184 DIWALGCMIIE 194 >2JAM-A nrPDB Length = 304 Score = 65.9 bits (159), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 58/192 (30%), Positives = 91/192 (47%), Gaps = 15/192 (7%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLA-EANVMQQLDNPYIVRM 435 LGSG F V + + K A+K +K PA +D L E V++++ + IV + Sbjct: 17 LGSGAFSEV--FLVKQRLTGKLFALKCIKK---SPAFRDSSLENEIAVLKKIKHENIVTL 71 Query: 436 IGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRD 494 I E+ + + LVM++ G L + + +K+ ++ QV +KYL E+ VHRD Sbjct: 72 EDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRD 131 Query: 495 LAARNVLLVT---QHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 L N+L +T I+DFGLSK + T G + APE + +S Sbjct: 132 LKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPG-----YVAPEVLAQKPYSK 186 Query: 552 KSDVWSFGVLMW 563 D WS GV+ + Sbjct: 187 AVDCWSIGVITY 198 >2QKW-B nrPDB Length = 321 Score = 65.9 bits (159), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 63/228 (27%), Positives = 103/228 (45%), Gaps = 24/228 (10%) Query: 346 EVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILK 405 E Y P D EE D K L +G G FG V KG V++ A LK Sbjct: 25 ESYRVPLVDLEEATNN---FDHKFL------IGHGVFGKVYKG------VLRDGAKVALK 69 Query: 406 NEANDPAL-KDELLAEANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQN 463 + + +E E + +P++V +IG C+ + M L+ + E G L ++L + Sbjct: 70 RRTPESSQGIEEFETEIETLSFCRHPHLVSLIGFCDERNEMILIYKYMENGNLKRHLYGS 129 Query: 464 ----RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLS-KA 518 + + +E+ + G+ YL +HRD+ + N+LL KI+DFG+S K Sbjct: 130 DLPTMSMSWEQRLEICIGAARGLHYLHTRAIIHRDVKSINILLDENFVPKITDFGISKKG 189 Query: 519 LRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAF 566 D+ + G + + PE + + KSDV+SFGV+++E Sbjct: 190 TELDQTHLSTVVKG--TLGYIDPEYFIKGRLTEKSDVYSFGVVLFEVL 235 >4AF3-A nrPDB Length = 292 Score = 65.5 bits (158), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 66/259 (25%), Positives = 113/259 (43%), Gaps = 15/259 (5%) Query: 370 LTLEDKE----LGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVM 424 T++D E LG G FG V + KK VA+K+L K++ ++ +L E + Sbjct: 20 FTIDDFEIGRPLGKGKFGNVYLA--REKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQ 77 Query: 425 QQLDNPYIVRMIG-ICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMK 483 L +P I+R+ + L++E A G L K LQ++ ++ ++ +++ + Sbjct: 78 AHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALM 137 Query: 484 YLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPEC 543 Y +HRD+ N+LL + KI+DFG S + T + + PE Sbjct: 138 YCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGT-----LDYLPPEM 192 Query: 544 INYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYD 603 I + K D+W GVL +E G P+ +E + K + + PA P D Sbjct: 193 IEGRMHNEKVDLWCIGVLCYELL-VGNPPFESASHNETYRRIVKVD-LKFPASVPTGAQD 250 Query: 604 LMNLCWTYDVENRPGFAAV 622 L++ ++ R A V Sbjct: 251 LISKLLRHNPSERLPLAQV 269 >4APC-A nrPDB Length = 350 Score = 65.5 bits (158), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 44/196 (22%), Positives = 98/196 (50%), Gaps = 14/196 (7%) Query: 375 KELGSGNFGT---VKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPY 431 +++G G+FG VK + V+K + + + ++ ++E E V+ + +P Sbjct: 30 QKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKE-----REESRREVAVLANMKHPN 84 Query: 432 IVRMI-GICEAESWMLVMEMAELGPLNKYLQQNRHV--KDKNIIELVHQVSMGMKYLEES 488 IV+ E S +VM+ E G L K + + V ++ I++ Q+ + +K++ + Sbjct: 85 IVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDR 144 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 +HRD+ ++N+ L ++ DFG+++ L + +A + + +PE Sbjct: 145 KILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPY---YLSPEICENKP 201 Query: 549 FSSKSDVWSFGVLMWE 564 +++KSD+W+ G +++E Sbjct: 202 YNNKSDIWALGCVLYE 217 >4NIF-A nrPDB Length = 333 Score = 65.5 bits (158), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 46/202 (22%), Positives = 92/202 (45%), Gaps = 16/202 (7%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G G++ K+ ++ + AVK++ DP+ + E+L ++ +P I+ + Sbjct: 16 IGVGSYSECKRCVHKATNM--EYAVKVIDKSKRDPSEEIEIL-----LRYGQHPNIITLK 68 Query: 437 GICE-AESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDL 495 + + + LV E+ G L + + + ++ ++H + ++YL VHRDL Sbjct: 69 DVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDL 128 Query: 496 AARNVLLVTQ----HYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 N+L V + +I DFG +K LRA+ + + APE + + Sbjct: 129 KPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPC---YTANFVAPEVLKRQGYDE 185 Query: 552 KSDVWSFGVLMWEAFSYGQKPY 573 D+WS G+L++ + G P+ Sbjct: 186 GCDIWSLGILLYTMLA-GYTPF 206 >2W96-B nrPDB Length = 306 Score = 65.1 bits (157), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 51/201 (25%), Positives = 88/201 (43%), Gaps = 16/201 (7%) Query: 376 ELGSGNFGTVKKGY-YQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 E+G G +GTV K V +V++ E P +A ++ ++P +VR Sbjct: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFEHPNVVR 70 Query: 435 MIGICEAE------SWMLVMEMAELGPLNKYLQQNRH--VKDKNIIELVHQVSMGMKYLE 486 ++ +C LV E + L YL + + + I +L+ Q G+ +L Sbjct: 71 LMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLH 129 Query: 487 ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECIN 545 + VHRDL N+L+ + K++DFGL++ Y+ WY APE + Sbjct: 130 ANCIVHRDLKPENILVTSGGTVKLADFGLARIYS-----YQMALDPVVVTLWYRAPEVLL 184 Query: 546 YYKFSSKSDVWSFGVLMWEAF 566 +++ D+WS G + E F Sbjct: 185 QSTYATPVDMWSVGCIFAEMF 205 >4NST-A nrPDB Length = 351 Score = 65.1 bits (157), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 59/244 (24%), Positives = 109/244 (44%), Gaps = 23/244 (9%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G G +G V K + K + VA+K ++ + + E +++QL + +V M Sbjct: 21 IGEGTYGQVYKA--KDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMK 78 Query: 437 GICEAE-----------SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYL 485 I + ++ LV E + + H + +I + Q+ G++Y Sbjct: 79 EIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYC 138 Query: 486 EESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE--C 543 + NF+HRD+ N+LL K++DFGL++ ++E+ K WY P Sbjct: 139 HKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEES---RPYTNKVITLWYRPPELL 195 Query: 544 INYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYD 603 + +++ DVWS G ++ E F+ +KP + + A LE R+ C + CP D Sbjct: 196 LGEERYTPAIDVWSCGCILGELFT--KKPI--FQANLELAQLELISRL-CGSPCPAVWPD 250 Query: 604 LMNL 607 ++ L Sbjct: 251 VIKL 254 >4XBR-A nrPDB Length = 366 Score = 65.1 bits (157), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 62/245 (25%), Positives = 106/245 (43%), Gaps = 24/245 (9%) Query: 334 KGPQREALPMDTEVYESPY---ADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYY 390 + PQRE + E + + DP + R YLD + ++G G+ G V Sbjct: 65 RSPQREPQRVSHEQFRAALQLVVDPGDPRS---YLDNFI------KIGEGSTGIV--CIA 113 Query: 391 QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIG--ICEAESWMLVM 448 ++ K VAVK K + ++ L E +M+ + +V M + E W +VM Sbjct: 114 TVRSSGKLVAVK--KMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELW-VVM 170 Query: 449 EMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA 508 E E G L + R + ++ I + V + L +HRD+ + ++LL Sbjct: 171 EFLEGGALTDIVTHTR-MNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRV 229 Query: 509 KISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSY 568 K+SDFG + + K+ + W APE I+ + + D+WS G+++ E Sbjct: 230 KLSDFGFCAQVSKEVPRRKSLVGTPY---WMAPELISRLPYGPEVDIWSLGIMVIEMVD- 285 Query: 569 GQKPY 573 G+ PY Sbjct: 286 GEPPY 290 >4I6B-A nrPDB Length = 308 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 56/252 (22%), Positives = 110/252 (43%), Gaps = 13/252 (5%) Query: 375 KELGSGNFGTVKKGYYQMKKVV--KTVAVKIL-KNEANDPALKDELLAEANVMQQLDNPY 431 K LG G F Y+M + K A KI+ + + P ++++ E + + L + + Sbjct: 34 KTLGKGGFAKC----YEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHHKH 89 Query: 432 IVRMIGICE-AESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 +V+ E E+ +++E + L+ + + + + + Q+ G+KYL E Sbjct: 90 VVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEI 149 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 +HRDL N + K+ DFGL+ L E ++ +T P + +PE +N Sbjct: 150 LHRDLKLGNFFINESMELKVGDFGLAARLEPLE--HRRRTICGTP-NYLSPEVLNKQGHG 206 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWT 610 ++SD+W+ G +M+ G+ P+ E + + R P+ L+ + Sbjct: 207 AESDIWALGCVMYTML-LGRPPFETTNLKETYRSIREA-RYTMPSSLLAPAKHLIASMLS 264 Query: 611 YDVENRPGFAAV 622 + E+RP + Sbjct: 265 KNPEDRPSLDDI 276 >3GC0-A nrPDB Length = 329 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 54/226 (23%), Positives = 102/226 (45%), Gaps = 16/226 (7%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 +LG G +G V K + +TVA+K ++ E + + + E +++++L + I+ + Sbjct: 41 KLGEGTYGEVYKAIDTVTN--ETVAIKRIRLEHEEEGVPGTAIREVSLLKELQHRNIIEL 98 Query: 436 IGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRD 494 + + L+ E AE L KY+ +N V + I ++Q+ G+ + +HRD Sbjct: 99 KSVIHHNHRLHLIFEYAE-NDLKKYMDKNPDVSMRVIKSFLYQLINGVNFCHSRRCLHRD 157 Query: 495 LAARNVLLVTQHYA-----KISDFGLSKALRADENYYKAQTHGKWPVKWYAPEC-INYYK 548 L +N+LL + KI DFGL++A + + W + PE + Sbjct: 158 LKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLW---YRPPEILLGSRH 214 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP 594 +S+ D+WS + W + G SE+ + + E +G P Sbjct: 215 YSTSVDIWSIACI-WAEMLMKTPLFPG--DSEIDQLFKIFEVLGLP 257 >5JZN-A nrPDB Length = 280 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 57/208 (27%), Positives = 102/208 (49%), Gaps = 19/208 (9%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLA-EANVMQQLDNPYIV 433 + +G GNF VK+ + + A+KI+K K+ ++ E ++++++ +P IV Sbjct: 25 RTIGDGNFAVVKECVE--RSTAREYALKIIKKSKCRG--KEHMIQNEVSILRRVKHPNIV 80 Query: 434 RMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 +I + + + LVME+ + G L + +++ +++ ++ +KYL N VH Sbjct: 81 LLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVH 140 Query: 493 RDLAARNVLLVTQH-----YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY 547 RD+ N LLV +H K+ DFGL+ + D Y T P + APE I Sbjct: 141 RDIKPEN-LLVYEHQDGSKSLKLGDFGLATIV--DGPLY---TVCGTP-TYVAPEIIAET 193 Query: 548 KFSSKSDVWSFGVLMWEAFSYGQKPYRG 575 + K D+W+ GV+ + G P+RG Sbjct: 194 GYGLKVDIWAAGVITYILLC-GFPPFRG 220 >4TN6-A nrPDB Length = 318 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 73/282 (25%), Positives = 126/282 (44%), Gaps = 41/282 (14%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +++GSG+FG + G + VA+K+ + P +L E+ + + + + Sbjct: 13 RKIGSGSFGDIYLG--TDIAAGEEVAIKLECVKTKHP----QLHIESKIYKMMQGGVGIP 66 Query: 435 MIGICEAESWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 I C AE VM M LGP + L +R K ++ L Q+ ++Y+ NF+H Sbjct: 67 TIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIH 126 Query: 493 RDLAARNVLL---VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVK---------WYA 540 RD+ N L+ + I DFGL+K Y A+TH P + YA Sbjct: 127 RDVKPDNFLMGLGKKGNLVYIIDFGLAK------KYRDARTHQHIPYRENKNLTGTARYA 180 Query: 541 PECINYY---KFSSKSDVWSFG-VLMWEAFSYGQKPYRGMKGSEVTAMLEK--GERMGCP 594 IN + + S + D+ S G VLM+ F+ G P++G+K + E+ ++M P Sbjct: 181 S--INTHLGIEQSRRDDLESLGYVLMY--FNLGSLPWQGLKAATKRQKYERISEKKMSTP 236 Query: 595 A-----GCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYY 631 G P E +N C + +++P ++ + RN ++ Sbjct: 237 IEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFH 278 >2Q0N-A nrPDB Length = 301 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 62/244 (25%), Positives = 105/244 (43%), Gaps = 24/244 (9%) Query: 335 GPQREALPMDTEVYESPY---ADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQ 391 PQRE + E + + DP + R YLD + ++G G+ G V Sbjct: 1 SPQREPQRVSHEQFRAALQLVVDPGDPRS---YLDNFI------KIGEGSTGIV--CIAT 49 Query: 392 MKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIG--ICEAESWMLVME 449 ++ K VAVK K + ++ L E +M+ + +V M + E W +VME Sbjct: 50 VRSSGKLVAVK--KMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELW-VVME 106 Query: 450 MAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAK 509 E G L + R + ++ I + V + L +HRD+ + ++LL K Sbjct: 107 FLEGGALTDIVTHTR-MNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVK 165 Query: 510 ISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYG 569 +SDFG + + K+ + W APE I+ + + D+WS G+++ E G Sbjct: 166 LSDFGFCAQVSKEVPRRKSLVGTPY---WMAPELISRLPYGPEVDIWSLGIMVIEMVD-G 221 Query: 570 QKPY 573 + PY Sbjct: 222 EPPY 225 >3TXO-A nrPDB Length = 353 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 52/205 (25%), Positives = 92/205 (44%), Gaps = 15/205 (7%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE----LLAEANVMQQLDN-PY 431 LG G+FG V ++K+ AVK+LK D L+D+ + E ++ N P+ Sbjct: 31 LGKGSFGKVMLA--RVKETGDLYAVKVLKK---DVILQDDDVECTMTEKRILSLARNHPF 85 Query: 432 IVRMIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 + ++ + + VME G L ++Q++R + ++ + +L + Sbjct: 86 LTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGI 145 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 ++RDL NVLL + + K++DFG+ K N T P + APE + + Sbjct: 146 IYRDLKLDNVLLDHEGHCKLADFGMCK--EGICNGVTTATFCGTP-DYIAPEILQEMLYG 202 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRG 575 D W+ GVL++E G P+ Sbjct: 203 PAVDWWAMGVLLYEMLC-GHAPFEA 226 >2JDO-A nrPDB Length = 342 Score = 64.3 bits (155), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 57/203 (28%), Positives = 94/203 (46%), Gaps = 12/203 (5%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDEL---LAEANVMQQLDNPY 431 K LG G FG V + K + A+KIL+ E KDE+ + E+ V+Q +P+ Sbjct: 16 KLLGKGTFGKVI--LVREKATGRYYAMKILRKEV--IIAKDEVAHTVTESRVLQNTRHPF 71 Query: 432 IVRM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 + + + VME A G L +L + R ++ ++ ++YL + Sbjct: 72 LTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDV 131 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 V+RD+ N++L + KI+DFGL K +D K T P ++ APE + + Sbjct: 132 VYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMK--TFCGTP-EYLAPEVLEDNDYG 188 Query: 551 SKSDVWSFGVLMWEAFSYGQKPY 573 D W GV+M+E G+ P+ Sbjct: 189 RAVDWWGLGVVMYEMMC-GRLPF 210 >2RIO-A nrPDB Length = 434 Score = 64.3 bits (155), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 72/286 (25%), Positives = 128/286 (44%), Gaps = 47/286 (16%) Query: 368 KLLTLEDKELGSGNFGTVK-KGYYQMKKVVKTVAVKILKNEANDPALKD-ELLAEANVMQ 425 K L + +K LG G+ GTV +G +Q + VAVK + + D AL + +LL E++ Sbjct: 14 KNLVVSEKILGYGSSGTVVFQGSFQGR----PVAVKRMLIDFCDIALMEIKLLTESD--- 66 Query: 426 QLDNPYIVRMIGICEAESWMLVMEMAELGPLN-KYLQQNRHVKDKNI--------IELVH 476 D+P ++R C + + EL LN + L ++++V D+N+ I L+ Sbjct: 67 --DHPNVIRYY--CSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLR 122 Query: 477 QVSMGMKYLEESNFVHRDLAARNVLLVTQHYAK-------------ISDFGLSKALRADE 523 Q++ G+ +L +HRDL +N+L+ T ISDFGL K L + + Sbjct: 123 QIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQ 182 Query: 524 NYYKAQTHGKWPVK-WYAPECI-------NYYKFSSKSDVWSFGVLMWEAFSYGQKPY-- 573 + ++ + W APE + + + D++S G + + S G+ P+ Sbjct: 183 SSFRTNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGD 242 Query: 574 RGMKGSEVTAMLEKGERMGC--PAGCPREMYDLMNLCWTYDVENRP 617 + + S + + + M C E DL++ +D RP Sbjct: 243 KYSRESNIIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRP 288 >3GC9-A nrPDB Length = 370 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 51/200 (25%), Positives = 98/200 (49%), Gaps = 22/200 (11%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 + +GSG +G+V Y ++ + VAVK L E +++ L + ++ Sbjct: 34 RPVGSGAYGSVCSAYD--ARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIG 91 Query: 435 MIGICE--------AESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE 486 ++ + +E +++ M LN ++ ++ + D+++ LV+Q+ G+KY+ Sbjct: 92 LLDVFTPATSIEDFSEVYLVTTLMG--ADLNNIVK-SQALSDEHVQFLVYQLLRGLKYIH 148 Query: 487 ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APEC-I 544 + +HRDL NV + +I DFGL++ +ADE + G +WY APE + Sbjct: 149 SAGIIHRDLKPSNVAVNEDSELRILDFGLAR--QADE-----EMTGYVATRWYRAPEIML 201 Query: 545 NYYKFSSKSDVWSFGVLMWE 564 N+ ++ D+WS G +M E Sbjct: 202 NWMHYNQTVDIWSVGCIMAE 221 >4QTB-A nrPDB Length = 380 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 50/197 (25%), Positives = 96/197 (48%), Gaps = 10/197 (5%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G G +G V Y ++K VA+K + + + L E ++ + + ++ + Sbjct: 49 IGEGAYGMVSSAYDHVRKT--RVAIKKISPFEHQTYCQ-RTLREIQILLRFRHENVIGIR 105 Query: 437 GICEA---ESWMLVMEMAELGPLNKY-LQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 I A E+ V + +L + Y L +++ + + +I ++Q+ G+KY+ +N +H Sbjct: 106 DILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLH 165 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APEC-INYYKFS 550 RDL N+L+ T KI DFGL++ + ++ T +WY APE +N ++ Sbjct: 166 RDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE-YVATRWYRAPEIMLNSKGYT 224 Query: 551 SKSDVWSFGVLMWEAFS 567 D+WS G ++ E S Sbjct: 225 KSIDIWSVGCILAEMLS 241 >3MV5-A nrPDB Length = 342 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 62/204 (30%), Positives = 91/204 (44%), Gaps = 13/204 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDEL---LAEANVMQQLDNPY 431 K LG G FG V + K + A+KILK E KDE+ L E V+Q +P+ Sbjct: 16 KLLGKGTFGKVI--LVKEKATGRYYAMKILKKEV--IVAKDEVAHTLTENRVLQNSRHPF 71 Query: 432 IVRM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYL-EESN 489 + + + VME A G L +L + R + ++ + YL E N Sbjct: 72 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 131 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 V+RDL N++L + KI+DFGL K D K T P ++ APE + + Sbjct: 132 VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMK--TFCGTP-EYLAPEVLEDNDY 188 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPY 573 D W GV+M+E G+ P+ Sbjct: 189 GRAVDWWGLGVVMYEMMC-GRLPF 211 >6DTL-A nrPDB Length = 364 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 46/195 (23%), Positives = 95/195 (48%), Gaps = 14/195 (7%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G G +G V + ++VA+K + N ++ L E +++ +D+ IV + Sbjct: 38 IGKGAYGIVCSA--MNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIR 95 Query: 437 GICEA------ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 I + E+ + L++ ++ N+ + +++ ++Q+ G+KY+ +N Sbjct: 96 DIIPPPLRNAFNDVYIAYELMDTD-LHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANV 154 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE-CINYYKF 549 +HRDL N+LL KI DFGL++ + ++ ++ +W + APE +N + Sbjct: 155 LHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTEYVVTRW---YRAPELLLNSSDY 210 Query: 550 SSKSDVWSFGVLMWE 564 ++ DVWS G + E Sbjct: 211 TAAIDVWSVGCIFME 225 >3MIA-A nrPDB Length = 351 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 51/206 (24%), Positives = 92/206 (44%), Gaps = 19/206 (9%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 ++G G FG V K + +K + VA+K + E L E ++Q L + +V + Sbjct: 24 KIGQGTFGEVFKARH--RKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNL 81 Query: 436 IGICEAE---------SWMLVMEMAE---LGPLNKYLQQNRHVKDKNIIELVHQVSMGMK 483 I IC + S LV + E G L+ L + + K +++++ G+ Sbjct: 82 IEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN---GLY 138 Query: 484 YLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE- 542 Y+ + +HRD+ A NVL+ K++DFGL++A +N + + WY P Sbjct: 139 YIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPE 198 Query: 543 -CINYYKFSSKSDVWSFGVLMWEAFS 567 + + D+W G +M E ++ Sbjct: 199 LLLGERDYGPPIDLWGAGCIMAEMWT 224 >3F3Z-A nrPDB Length = 277 Score = 63.5 bits (153), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 62/228 (27%), Positives = 98/228 (42%), Gaps = 27/228 (11%) Query: 371 TLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNP 430 TLE+ +G G++G VK Q ++ A KI K D D E +M+ LD+P Sbjct: 12 TLENT-IGRGSWGEVKIAV-QKGTRIRRAAKKIPKYFVED---VDRFKQEIEIMKSLDHP 66 Query: 431 YIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 I+R+ E + + LVME+ G L + + R ++ + ++ V + Y + N Sbjct: 67 NIIRLYETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLN 126 Query: 490 FVHRDLAARNVLLVT---QHYAKISDFGLSKALRADENYYKAQTHGKWPVK------WYA 540 HRDL N L +T K+ DFGL+ + + + + + V Y Sbjct: 127 VAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGK-MMRTKVGTPYYVSPQVLEGLYG 185 Query: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG 588 PEC D WS GV+M+ G P+ SEV + +G Sbjct: 186 PEC----------DEWSAGVMMYVLLC-GYPPFSAPTDSEVMLKIREG 222 >2F9G-A nrPDB Length = 353 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 54/205 (26%), Positives = 93/205 (45%), Gaps = 21/205 (10%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 LG G +G V + K + VA+K ++ + P L E +++ + I+ + Sbjct: 19 LGEGAYGVVCSATH--KPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFKHENIITIF 75 Query: 437 GICEAESWMLVMEMAELGPLNKYLQQNRH-------VKDKNIIELVHQVSMGMKYLEESN 489 I +S+ E+ + + +Q + H + D +I ++Q +K L SN Sbjct: 76 NIQRPDSFE---NFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSN 132 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKAL---RADENYYKAQTHGKW---PVKWY-APE 542 +HRDL N+L+ + K+ DFGL++ + AD + Q G +WY APE Sbjct: 133 VIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPE 192 Query: 543 C-INYYKFSSKSDVWSFGVLMWEAF 566 + K+S DVWS G ++ E F Sbjct: 193 VMLTSAKYSRAMDVWSCGCILAELF 217 >1UA2-A nrPDB Length = 346 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 55/195 (28%), Positives = 96/195 (49%), Gaps = 14/195 (7%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILK----NEANDPALKDELLAEANVMQQLDNPYI 432 LG G F TV K + K + VA+K +K +EA D + L E ++Q+L +P I Sbjct: 18 LGEGQFATVYKA--RDKNTNQIVAIKKIKLGHRSEAKD-GINRTALREIKLLQELSHPNI 74 Query: 433 VRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM-GMKYLEESNF 490 + ++ +S + LV + E L ++ N V + I+ +++ G++YL + Sbjct: 75 IGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWI 133 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI-NYYKF 549 +HRDL N+LL K++DFGL+K+ + Y Q +W + APE + + Sbjct: 134 LHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFGARMY 190 Query: 550 SSKSDVWSFGVLMWE 564 D+W+ G ++ E Sbjct: 191 GVGVDMWAVGCILAE 205 >2BDW-A nrPDB Length = 362 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 48/194 (24%), Positives = 93/194 (47%), Gaps = 12/194 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +ELG G F V++ ++ + A KI+ + +L EA + ++L +P IVR Sbjct: 35 EELGKGAFSVVRRCVHKTTGL--EFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVR 92 Query: 435 MIGICEAESW-MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + + ES+ LV ++ G L + + + + + Q+ + Y + VHR Sbjct: 93 LHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIVHR 152 Query: 494 DLAARNVLLVTQ---HYAKISDFGLSKALRADENYYK-AQTHGKWPVKWYAPECINYYKF 549 +L N+LL ++ K++DFGL+ + E ++ A T G + +PE + + Sbjct: 153 NLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPG-----YLSPEVLKKDPY 207 Query: 550 SSKSDVWSFGVLMW 563 S D+W+ GV+++ Sbjct: 208 SKPVDIWACGVILY 221 >5KCV-A nrPDB Length = 460 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 62/204 (30%), Positives = 91/204 (44%), Gaps = 13/204 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDEL---LAEANVMQQLDNPY 431 K LG G FG V + K + A+KILK E KDE+ L E V+Q +P+ Sbjct: 168 KLLGKGTFGKVI--LVKEKATGRYYAMKILKKEV--IVAKDEVAHTLTENRVLQNSRHPF 223 Query: 432 IVRM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYL-EESN 489 + + + VME A G L +L + R + ++ + YL E N Sbjct: 224 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKN 283 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 V+RDL N++L + KI+DFGL K D K T P ++ APE + + Sbjct: 284 VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMK--TFCGTP-EYLAPEVLEDNDY 340 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPY 573 D W GV+M+E G+ P+ Sbjct: 341 GRAVDWWGLGVVMYEMMC-GRLPF 363 >1VZO-A nrPDB Length = 355 Score = 63.2 bits (152), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 51/210 (24%), Positives = 99/210 (47%), Gaps = 18/210 (8%) Query: 375 KELGSGNFGTVKKGYYQMKKVV-----KTVAVKILKNE--ANDPALKDELLAEANVMQQL 427 K LG+G +G V + ++K+ K A+K+LK + E V++ + Sbjct: 60 KVLGTGAYGKV----FLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHI 115 Query: 428 -DNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYL 485 +P++V + + E+ + L+++ G L +L Q + + V ++ + +++L Sbjct: 116 RQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHL 175 Query: 486 EESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 + ++RD+ N+LL + + ++DFGLSK ADE G +++ AP+ + Sbjct: 176 HKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCG--TIEYMAPDIVR 233 Query: 546 --YYKFSSKSDVWSFGVLMWEAFSYGQKPY 573 D WS GVLM+E + G P+ Sbjct: 234 GGDSGHDKAVDWWSLGVLMYELLT-GASPF 262 >4FG9-A nrPDB Length = 320 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 55/191 (28%), Positives = 89/191 (46%), Gaps = 11/191 (5%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 LG+G F V + K+ K VA+K + EA + + + E V+ ++ +P IV + Sbjct: 26 LGTGAFSEVILA--EDKRTQKLVAIKCIAKEALE-GKEGSMENEIAVLHKIKHPNIVALD 82 Query: 437 GICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDL 495 I E+ + L+M++ G L + + +++ L+ QV +KYL + VHRDL Sbjct: 83 DIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDL 142 Query: 496 AARNVL---LVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSK 552 N+L L ISDFGLSK E+ + + APE + +S Sbjct: 143 KPENLLYYSLDEDSKIMISDFGLSKM----EDPGSVLSTACGTPGYVAPEVLAQKPYSKA 198 Query: 553 SDVWSFGVLMW 563 D WS GV+ + Sbjct: 199 VDCWSIGVIAY 209 >4QNY-A nrPDB Length = 354 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 60/240 (25%), Positives = 114/240 (47%), Gaps = 23/240 (9%) Query: 366 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEA-NDPALKDELLAEANVM 424 DR LL ++ +G+G++G V + K + VA+K + E + L +L E ++ Sbjct: 20 DRYLL---ERIIGAGSYGVVIRAR-DTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLL 75 Query: 425 QQLDNPYIVRMIGICEAES------WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQV 478 ++ I+ + I E + +VM++ E L + L+ + + + +I ++Q Sbjct: 76 AHFNDDNIIGLRNILTPEDPENFDHFYIVMDIME-TDLKQVLRSGQELTEAHIQFFIYQA 134 Query: 479 SMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKW 538 + + + +HRD+ N+L+ T KI DFGL+K +EN ++W Sbjct: 135 LRALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAK----EENDQGEYMTDYVTMRW 190 Query: 539 Y-APECINYYK-FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK-GERMGCPA 595 Y APE + K +S++ DVW G ++ E G +P +G + L+K + +G P+ Sbjct: 191 YRAPELVMEDKDYSAQIDVWGIGCILGELL--GSRPL--FQGKDRVNQLDKIVDVIGTPS 246 >3KK8-A nrPDB Length = 284 Score = 62.8 bits (151), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 48/194 (24%), Positives = 93/194 (47%), Gaps = 12/194 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +ELG G F V++ ++ + A KI+ + +L EA + ++L +P IVR Sbjct: 12 EELGKGAFSVVRRCVHKTTGL--EFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVR 69 Query: 435 MIGICEAESW-MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + + ES+ LV ++ G L + + + + + Q+ + Y + VHR Sbjct: 70 LHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIVHR 129 Query: 494 DLAARNVLLVTQ---HYAKISDFGLSKALRADENYYK-AQTHGKWPVKWYAPECINYYKF 549 +L N+LL ++ K++DFGL+ + E ++ A T G + +PE + + Sbjct: 130 NLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPG-----YLSPEVLKKDPY 184 Query: 550 SSKSDVWSFGVLMW 563 S D+W+ GV+++ Sbjct: 185 SKPVDIWACGVILY 198 >2V7O-A nrPDB Length = 336 Score = 62.4 bits (150), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 48/195 (24%), Positives = 93/195 (47%), Gaps = 13/195 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +ELG G F V++ K + A KI+ + +L EA + + L +P IVR Sbjct: 37 EELGKGAFSVVRRCV--KKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVR 94 Query: 435 M-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + I E LV ++ G L + + + + + +HQ+ + ++ + + VHR Sbjct: 95 LHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHR 154 Query: 494 DLAARNVLLVTQ---HYAKISDFGLSKALRADENYY--KAQTHGKWPVKWYAPECINYYK 548 DL N+LL ++ K++DFGL+ ++ ++ + A T G + +PE + Sbjct: 155 DLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPG-----YLSPEVLRKDP 209 Query: 549 FSSKSDVWSFGVLMW 563 + D+W+ GV+++ Sbjct: 210 YGKPVDIWACGVILY 224 >4IC8-A nrPDB Length = 442 Score = 62.0 bits (149), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 46/206 (22%), Positives = 100/206 (48%), Gaps = 18/206 (8%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G+G +G V ++ + VA+K + N + L E +++ + I+ + Sbjct: 63 IGNGAYGVVSSARRRLTG--QQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIK 120 Query: 437 GIC-------EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 I E +S +V+++ E L++ + ++ + +++ ++Q+ G+KY+ + Sbjct: 121 DILRPTVPYGEFKSVYVVLDLME-SDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQ 179 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKAL---RADENYYKAQTHGKWPVKWY-APEC-I 544 +HRDL N+L+ KI DFG+++ L A+ Y+ + +WY APE + Sbjct: 180 VIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVA---TRWYRAPELML 236 Query: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQ 570 + ++++ D+WS G + E + Q Sbjct: 237 SLHEYTQAIDLWSVGCIFGEMLARRQ 262 >4B6L-A nrPDB Length = 281 Score = 62.0 bits (149), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 49/204 (24%), Positives = 91/204 (44%), Gaps = 8/204 (3%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNP 430 L+ + LG G F + + AVK++ ++ P ++++L E + + L + Sbjct: 12 LKGRLLGKGGFARCYEA--TDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHR 69 Query: 431 YIVRMIGICE-AESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 +IVR E A++ + +E+ L + + + + + Q+ G+KYL + Sbjct: 70 HIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRG 129 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 +HRDL N + K+ DFGL+ L E + +T P + APE + Sbjct: 130 ILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQ--RKKTICGTP-NYVAPEVLLRQGH 186 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPY 573 ++DVWS G +M+ G P+ Sbjct: 187 GPEADVWSLGCVMYTLLC-GSPPF 209 >4TNB-A nrPDB Length = 590 Score = 61.6 bits (148), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 55/206 (26%), Positives = 97/206 (47%), Gaps = 13/206 (6%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDEL-LAEANVMQQLDNPYIVRM 435 LG G FG V Q++ K A K L+ + + + L E +++++++ ++V + Sbjct: 192 LGKGGFGEV--CACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249 Query: 436 IGICEA-ESWMLVMEMAELGPL--NKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 E ++ LV+ + G L + Y N +++ + ++ G++ L N V+ Sbjct: 250 AYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHENTVY 309 Query: 493 RDLAARNVLLVTQHYAKISDFGLS-KALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 RDL N+LL + +ISD GL+ K D + T G + APE +N ++ Sbjct: 310 RDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVG-----YMAPEVLNNQRYGL 364 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMK 577 D W G L++E GQ P+RG K Sbjct: 365 SPDYWGLGCLIYEMIE-GQSPFRGRK 389 >3UTO-A nrPDB Length = 573 Score = 61.6 bits (148), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 63/240 (26%), Positives = 107/240 (44%), Gaps = 17/240 (7%) Query: 346 EVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILK 405 ++++ Y P EI+ V LD + +ELG+G FG V + + A K + Sbjct: 138 DIWKQYYPQPVEIKHDHV-LDHYDI---HEELGTGAFGVVHR--VTERATGNNFAAKFVM 191 Query: 406 NEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPL-NKYLQQN 463 + K+ + E M L +P +V + E ++ M ++ E G L K ++ Sbjct: 192 TPHE--SDKETVRKEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEH 249 Query: 464 RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQ--HYAKISDFGLSKALRA 521 + + +E + QV G+ ++ E+N+VH DL N++ T+ + K+ DFGL+ L Sbjct: 250 NKMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHL-- 307 Query: 522 DENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 D T G ++ APE +D+WS GVL + S G P+ G E Sbjct: 308 DPKQSVKVTTGT--AEFAAPEVAEGKPVGYYTDMWSVGVLSYILLS-GLSPFGGENDDET 364 >6CCF-A nrPDB Length = 290 Score = 61.6 bits (148), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 44/160 (27%), Positives = 85/160 (53%), Gaps = 11/160 (6%) Query: 420 EANVMQQLDNPYIVRMIGICE---AESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVH 476 E ++++LD+ +V++I + + ++ LV ++ GP+ + + ++ ++ + Sbjct: 78 EIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCDKPFSEEQARLYLR 136 Query: 477 QVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPV 536 V +G++YL VHRD+ N+LL + KI+DFG+S ++ + T G Sbjct: 137 DVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQL-SSTAGT--P 193 Query: 537 KWYAPECINY--YKFSSKS-DVWSFGVLMWEAFSYGQKPY 573 + APE I+ FS K+ DVW+ GV ++ F YG+ P+ Sbjct: 194 AFMAPEAISDSGQSFSGKALDVWATGVTLY-CFVYGKCPF 232 >2XS0-A nrPDB Length = 386 Score = 61.6 bits (148), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 67/256 (26%), Positives = 115/256 (44%), Gaps = 28/256 (10%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K +GSG G V Y + + + VA+K L + E +M+ +++ I+ Sbjct: 32 KPIGSGAQGIVCAAYDAILE--RNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIG 89 Query: 435 MIGIC-------EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 487 ++ + E + +VME+ + L + +Q + + + L++Q+ G+K+L Sbjct: 90 LLNVFTPQKSLEEFQDVYIVMELMDAN-LCQVIQM--ELDHERMSYLLYQMLCGIKHLHS 146 Query: 488 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY--APECIN 545 + +HRDL N+++ + KI DFGL++ A ++ + V Y APE I Sbjct: 147 AGIIHRDLKPSNIVVKSDCTLKILDFGLART--AGTSFMMV----PFVVTRYYRAPEVIL 200 Query: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG-ERMGCPAGCPREMYDL 604 + D+WS G +M E G G++ K E++G P CP M L Sbjct: 201 GMGYKENVDIWSVGCIMGEMIKGGVL----FPGTDHIDQWNKVIEQLGTP--CPEFMKKL 254 Query: 605 MNLCWTYDVENRPGFA 620 TY VENRP +A Sbjct: 255 QPTVRTY-VENRPKYA 269 >1KOA-A nrPDB Length = 491 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 63/240 (26%), Positives = 107/240 (44%), Gaps = 17/240 (7%) Query: 346 EVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILK 405 ++++ Y P EI+ V LD + +ELG+G FG V + + A K + Sbjct: 32 DIWKQYYPQPVEIKHDHV-LDHYDI---HEELGTGAFGVVHR--VTERATGNNFAAKFVM 85 Query: 406 NEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPL-NKYLQQN 463 + K+ + E M L +P +V + E ++ M ++ E G L K ++ Sbjct: 86 TPHE--SDKETVRKEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEH 143 Query: 464 RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQ--HYAKISDFGLSKALRA 521 + + +E + QV G+ ++ E+N+VH DL N++ T+ + K+ DFGL+ L Sbjct: 144 NKMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHL-- 201 Query: 522 DENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 D T G ++ APE +D+WS GVL + S G P+ G E Sbjct: 202 DPKQSVKVTTGT--AEFAAPEVAEGKPVGYYTDMWSVGVLSYILLS-GLSPFGGENDDET 258 >4ZSG-A nrPDB Length = 347 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 46/206 (22%), Positives = 100/206 (48%), Gaps = 18/206 (8%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G+G +G V ++ + VA+K + N + L E +++ + I+ + Sbjct: 15 IGNGAYGVVSSARRRLTG--QQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIK 72 Query: 437 GIC-------EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 I E +S +V+++ E L++ + ++ + +++ ++Q+ G+KY+ + Sbjct: 73 DILRPTVPYGEFKSVYVVLDLME-SDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQ 131 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKAL---RADENYYKAQTHGKWPVKWY-APEC-I 544 +HRDL N+L+ KI DFG+++ L A+ Y+ + +WY APE + Sbjct: 132 VIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVA---TRWYRAPELML 188 Query: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQ 570 + ++++ D+WS G + E + Q Sbjct: 189 SLHEYTQAIDLWSVGCIFGEMLARRQ 214 >4CRS-A nrPDB Length = 341 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 61/212 (28%), Positives = 100/212 (47%), Gaps = 16/212 (7%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE---LLAEANVMQQLDN---P 430 L G+FG V Y K + A+K LK D +DE L+ E + + +++ P Sbjct: 20 LLRGHFGKVLLAEY--KNTNEMFAIKALKK--GDIVARDEVDSLMCEKRIFETVNSVRHP 75 Query: 431 YIVRMIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 ++V + + E VME A G L ++ + + + + V +G++YL E Sbjct: 76 FLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVF-YAACVVLGLQYLHEHK 134 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 V+RDL N+LL T+ + KI+DFGL K + + T P ++ APE + + Sbjct: 135 IVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGD--RTSTFCGTP-EFLAPEVLTETSY 191 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 + D W GVL++E G+ P+ G EV Sbjct: 192 TRAVDWWGLGVLIYEML-VGESPFPGDDEEEV 222 >3KA0-A nrPDB Length = 320 Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 42/173 (24%), Positives = 82/173 (47%), Gaps = 15/173 (8%) Query: 430 PYIVRMIGICE-----AESWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGM 482 P+IVR++ + E + ++VME + G L +Q ++ ++ E++ + + Sbjct: 69 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 128 Query: 483 KYLEESNFVHRDLAARNVLLVTQH---YAKISDFGLSKALRADENYYKAQTHGKWPVKWY 539 +YL N HRD+ N+L ++ K++DFG +K + + + T + + Sbjct: 129 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK----ETTSHNSLTEPCYTPYYV 184 Query: 540 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMG 592 APE + K+ D+WS GV+M+ G P+ G ++ ++ RMG Sbjct: 185 APEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMG 236 >4EUT-A nrPDB Length = 396 Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 60/241 (24%), Positives = 109/241 (45%), Gaps = 22/241 (9%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 LG G V +G + KK A+K+ N + + D + E V+++L++ IV++ Sbjct: 17 LGQGATANVFRGRH--KKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLF 73 Query: 437 GICEAESW---MLVMEMAELGPLNKYLQQNRH---VKDKNIIELVHQVSMGMKYLEESNF 490 I E + +L+ME G L L++ + + + + ++ V GM +L E+ Sbjct: 74 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 133 Query: 491 VHRDLAARNVLLVT----QHYAKISDFGLSKALRADENYYKAQ-THGKWPVKWYAPECI- 544 VHR++ N++ V Q K++DFG ++ L DE + T Y + Sbjct: 134 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 193 Query: 545 --NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKG----SEVTAMLEKGERMGCPAGCP 598 + K+ + D+WS GV + A + G P+R +G EV + G+ G +G Sbjct: 194 KDHQKKYGATVDLWSIGVTFYHA-ATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQ 252 Query: 599 R 599 + Sbjct: 253 K 253 >4JLC-A nrPDB Length = 657 Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 62/241 (25%), Positives = 109/241 (45%), Gaps = 22/241 (9%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 LG G V +G + KK AVK+ N + + D + E V+++L++ IV++ Sbjct: 16 LGQGATANVFRGRH--KKTGDLYAVKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLF 72 Query: 437 GICEAESW---MLVMEMAELGPLNKYLQQNRH---VKDKNIIELVHQVSMGMKYLEESNF 490 I E + +L+ME G L L++ + + + + ++ V GM +L E+ Sbjct: 73 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 132 Query: 491 VHRDLAARNVLLVT----QHYAKISDFGLSKALRADENYYKAQ-THGKWPVKWYAPECI- 544 VHRD+ N++ V Q K++DFG ++ L DE + T Y + Sbjct: 133 VHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 192 Query: 545 --NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKG----SEVTAMLEKGERMGCPAGCP 598 + K+ + D+WS GV + A + G P+R +G EV + G+ G +G Sbjct: 193 KDHQKKYGATVDLWSVGVTFYHA-ATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQ 251 Query: 599 R 599 + Sbjct: 252 K 252 >4EUU-A nrPDB Length = 319 Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 60/241 (24%), Positives = 109/241 (45%), Gaps = 22/241 (9%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 LG G V +G + KK A+K+ N + + D + E V+++L++ IV++ Sbjct: 17 LGQGATANVFRGRH--KKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLF 73 Query: 437 GICEAESW---MLVMEMAELGPLNKYLQQNRH---VKDKNIIELVHQVSMGMKYLEESNF 490 I E + +L+ME G L L++ + + + + ++ V GM +L E+ Sbjct: 74 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 133 Query: 491 VHRDLAARNVLLVT----QHYAKISDFGLSKALRADENYYKA-QTHGKWPVKWYAPECI- 544 VHR++ N++ V Q K++DFG ++ L DE + T Y + Sbjct: 134 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 193 Query: 545 --NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKG----SEVTAMLEKGERMGCPAGCP 598 + K+ + D+WS GV + A + G P+R +G EV + G+ G +G Sbjct: 194 KDHQKKYGATVDLWSIGVTFYHA-ATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQ 252 Query: 599 R 599 + Sbjct: 253 K 253 >2OZA-A nrPDB Length = 356 Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 42/173 (24%), Positives = 82/173 (47%), Gaps = 15/173 (8%) Query: 430 PYIVRMIGICE-----AESWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGM 482 P+IVR++ + E + ++VME + G L +Q ++ ++ E++ + + Sbjct: 71 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 130 Query: 483 KYLEESNFVHRDLAARNVLLVTQH---YAKISDFGLSKALRADENYYKAQTHGKWPVKWY 539 +YL N HRD+ N+L ++ K++DFG +K + + + T + + Sbjct: 131 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK----ETTSHNSLTTPCYTPYYV 186 Query: 540 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMG 592 APE + K+ D+WS GV+M+ G P+ G ++ ++ RMG Sbjct: 187 APEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMG 238 >4YZB-A nrPDB Length = 491 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 59/221 (26%), Positives = 106/221 (47%), Gaps = 19/221 (8%) Query: 377 LGSGNFGTV---KKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 LG G+FG V K + VK ++ + +K + + L E ++++LD+P I+ Sbjct: 38 LGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLL----KEVELLKKLDHPNIM 93 Query: 434 RMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 ++ E + + LV E+ G L + + + + ++ QV G+ Y+ ++ VH Sbjct: 94 KLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVH 153 Query: 493 RDLAARNVLLVTQHY---AKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECINYYK 548 RDL N+LL + +I DFGLS + + + K +Y APE + + Sbjct: 154 RDLKPENLLLENKRKDANIRIIDFGLSTHFESTK-----KMKDKIGTAYYIAPEVL-HGT 207 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 + K DVWS GV+++ S G P+ G ++ +EKG+ Sbjct: 208 YDEKCDVWSTGVILYILLS-GCPPFNGANEFDILKKVEKGK 247 >2Y7J-A nrPDB Length = 365 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 45/179 (25%), Positives = 88/179 (49%), Gaps = 15/179 (8%) Query: 420 EANVMQQL-DNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQ 477 E ++++Q+ +P+I+ +I E+ S+M LV ++ G L YL + + +K ++ Sbjct: 149 ETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRS 208 Query: 478 VSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYK-AQTHGKWPV 536 + + +L +N VHRDL N+LL ++SDFG S L E + T G Sbjct: 209 LLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPG---- 264 Query: 537 KWYAPECI------NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 + APE + + + + D+W+ GV+++ + G P+ + + M+ +G+ Sbjct: 265 -YLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLA-GSPPFWHRRQILMLRMIMEGQ 321 >1NY3-A nrPDB Length = 400 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 42/173 (24%), Positives = 82/173 (47%), Gaps = 15/173 (8%) Query: 430 PYIVRMIGICE-----AESWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGM 482 P+IVR++ + E + ++VME + G L +Q ++ ++ E++ + + Sbjct: 115 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 174 Query: 483 KYLEESNFVHRDLAARNVLLVTQH---YAKISDFGLSKALRADENYYKAQTHGKWPVKWY 539 +YL N HRD+ N+L ++ K++DFG +K + + + T + + Sbjct: 175 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK----ETTSHNSLTTPCYTPYYV 230 Query: 540 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMG 592 APE + K+ D+WS GV+M+ G P+ G ++ ++ RMG Sbjct: 231 APEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMG 282 >4D28-A nrPDB Length = 446 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 52/192 (27%), Positives = 93/192 (48%), Gaps = 8/192 (4%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNPYIV 433 + +G G F VK + + VA+KI+ K+ + D++ E ++M+ + +P IV Sbjct: 15 RTIGEGTFAKVK--FARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIV 72 Query: 434 RMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 R+ + ++S + +V+E G L + +K+ + Q+ + + H Sbjct: 73 RLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHCHSKGVYH 132 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS-S 551 RDL N+LL T K+SDFGLS AL + T G + APE ++ + S Sbjct: 133 RDLKPENLLLDTNGNLKVSDFGLS-ALPQEGVELLNDTCG--TPNYVAPEVLSGQGYDGS 189 Query: 552 KSDVWSFGVLMW 563 +D+WS GV+++ Sbjct: 190 AADIWSCGVILF 201 >2H34-A nrPDB Length = 309 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 44/203 (21%), Positives = 93/203 (45%), Gaps = 11/203 (5%) Query: 377 LGSGNFGTVKKGYYQMKKVVK--TVAVKILKNE-ANDPALKDELLAEANVMQQLDNPYIV 433 +G G G V Y+ + V+ VA+K++ ++DP + + EA +L P++V Sbjct: 42 VGRGGMGDV----YEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPHVV 97 Query: 434 RMIGICEAESWMLV-MEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 + E + + V M + L L++ + + +V Q+ + + H Sbjct: 98 PIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHAAGATH 157 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSK 552 RD+ N+L+ +A + DFG++ A ++ T G + + APE + + + Sbjct: 158 RDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGT--LYYMAPERFSESHATYR 215 Query: 553 SDVWSFGVLMWEAFSYGQKPYRG 575 +D+++ +++E + G PY+G Sbjct: 216 ADIYALTCVLYECLT-GSPPYQG 237 >5D7A-A nrPDB Length = 308 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 51/204 (25%), Positives = 95/204 (46%), Gaps = 25/204 (12%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDN------- 429 +G+G +G V KG + K + A+K++ ++ ++E+ E N++++ + Sbjct: 25 VGNGTYGQVYKGRHV--KTGQLAAIKVMDVTGDE---EEEIKQEINMLKKYSHHRNIATY 79 Query: 430 --PYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNR--HVKDKNIIELVHQVSMGMKYL 485 +I + + + W LVME G + ++ + +K++ I + ++ G+ +L Sbjct: 80 YGAFIKKNPPGMDDQLW-LVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHL 138 Query: 486 EESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 + +HRD+ +NVLL K+ DFG+S L D + T P W APE I Sbjct: 139 HQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQL--DRTVGRRNTFIGTPY-WMAPEVIA 195 Query: 546 Y-----YKFSSKSDVWSFGVLMWE 564 + KSD+WS G+ E Sbjct: 196 CDENPDATYDFKSDLWSLGITAIE 219 >3FXW-A nrPDB Length = 336 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 51/231 (22%), Positives = 107/231 (46%), Gaps = 24/231 (10%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPY 431 L + LG G G V + ++ ++ + A+K+L + P + E+ + Q P+ Sbjct: 32 LSKQVLGLGVNGKVLECFH--RRTGQKCALKLL---YDSPKARQEV---DHHWQASGGPH 83 Query: 432 IVRMIGICE-----AESWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGMKY 484 IV ++ + E +++ME E G L +Q+ ++ ++ E++ + +++ Sbjct: 84 IVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQF 143 Query: 485 LEESNFVHRDLAARNVLLVTQH---YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 541 L N HRD+ N+L ++ K++DFG +K +N + + + + AP Sbjct: 144 LHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAK--ETTQNALQTPCYTPY---YVAP 198 Query: 542 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMG 592 E + K+ D+WS GV+M+ G P+ G ++ +++ R+G Sbjct: 199 EVLGPEKYDKSCDMWSLGVIMYILLC-GFPPFYSNTGQAISPGMKRRIRLG 248 >2BUJ-A nrPDB Length = 317 Score = 60.5 bits (145), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 62/272 (22%), Positives = 119/272 (43%), Gaps = 43/272 (15%) Query: 375 KELGSGNFGTVK-------KGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL 427 ++LG G F V +Y +K+ IL +E D ++E EA++ + Sbjct: 35 QKLGEGGFSYVDLVEGLHDGHFYALKR--------ILCHEQQD---REEAQREADMHRLF 83 Query: 428 DNPYIVRMIGIC------EAESWMLVMEMAELGPL----NKYLQQNRHVKDKNIIELVHQ 477 ++P I+R++ C + E+W+L + + G L + + + + I+ L+ Sbjct: 84 NHPNILRLVAYCLRERGAKHEAWLL-LPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLG 142 Query: 478 VSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFG-LSKALRADENYYKAQTHGKWP- 535 + G++ + + HRDL N+LL + + D G +++A E +A T W Sbjct: 143 ICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAA 202 Query: 536 ----VKWYAPECI---NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG 588 + + APE ++ ++DVWS G +++ A +G+ PY + + L Sbjct: 203 QRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLY-AMMFGEGPYDMVFQKGDSVALAVQ 261 Query: 589 ERMGCPAGCPRE---MYDLMNLCWTYDVENRP 617 ++ P PR ++ L+N T D RP Sbjct: 262 NQLSIPQS-PRHSSALWQLLNSMMTVDPHQRP 292 >5YV8-A nrPDB Length = 298 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 56/231 (24%), Positives = 109/231 (47%), Gaps = 34/231 (14%) Query: 371 TLEDKELGSGNFGTVKKGYYQMKKV---VKTVAVKILKNEANDPALK------------- 414 TL+D E+G G++G VK Y + +K ++ K L +A P Sbjct: 16 TLKD-EIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCI 74 Query: 415 ------DELLAEANVMQQLDNPYIVRMIGICE---AESWMLVMEMAELGPLNKYLQQNRH 465 +++ E ++++LD+P +V+++ + + + +V E+ GP+ + Sbjct: 75 QPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPL 134 Query: 466 VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENY 525 +D+ + G++YL +HRD+ N+L+ + KI+DFG+S + + Sbjct: 135 SEDQARFYF-QDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDAL 193 Query: 526 YKAQTHGKWPVKWYAPECINYYK--FSSKS-DVWSFGVLMWEAFSYGQKPY 573 + T G + APE ++ + FS K+ DVW+ GV ++ F +GQ P+ Sbjct: 194 L-SNTVGT--PAFMAPESLSETRKIFSGKALDVWAMGVTLY-CFVFGQCPF 240 >6O8B-A nrPDB Length = 665 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 60/241 (24%), Positives = 110/241 (45%), Gaps = 22/241 (9%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 LG G V +G + KK A+K+ N + + D + E V+++L++ IV++ Sbjct: 23 LGQGATANVFRGRH--KKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLF 79 Query: 437 GICEAESW---MLVMEMAELGPLNKYLQQNRH---VKDKNIIELVHQVSMGMKYLEESNF 490 I E + +L+ME G L L++ + + + + ++ V GM +L E+ Sbjct: 80 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 139 Query: 491 VHRDLAARNVLLVT----QHYAKISDFGLSKALRADENYYKAQ-THGKWPVKWYAPECI- 544 VHR++ N++ V Q K++DFG ++ L DE + + T Y + Sbjct: 140 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYERAVLR 199 Query: 545 --NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKG----SEVTAMLEKGERMGCPAGCP 598 + K+ + D+WS GV + A + G P+R +G EV + G+ G +G Sbjct: 200 KDHQKKYGATVDLWSIGVTFYHA-ATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQ 258 Query: 599 R 599 + Sbjct: 259 K 259 >6E2O-A nrPDB Length = 295 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 61/219 (27%), Positives = 98/219 (44%), Gaps = 16/219 (7%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 LG G +G V Y + + V + I + D L E + + L + IV+ + Sbjct: 30 LGKGTYGIV----YAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYL 85 Query: 437 GICEAESWM-LVMEMAELGPLNKYLQQN-RHVKD--KNIIELVHQVSMGMKYLEESNFVH 492 G ++ + ME G L+ L+ +KD + I Q+ G+KYL ++ VH Sbjct: 86 GSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVH 145 Query: 493 RDLAARNVLLVT-QHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY--YKF 549 RD+ NVL+ T KISDFG SK L + T +++ APE I+ + Sbjct: 146 RDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFT---GTLQYMAPEIIDKGPRGY 202 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG 588 +D+WS G + E + G+ P+ + G AM + G Sbjct: 203 GKAADIWSLGCTIIE-MATGKPPFYEL-GEPQAAMFKVG 239 >4IDT-A nrPDB Length = 356 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 67/245 (27%), Positives = 105/245 (42%), Gaps = 30/245 (12%) Query: 330 WAADKGPQREALPMDTEVYESPYADPEEIRPKEV-YLDRKLLTLEDKELGSGNFGTVKKG 388 WAA RE P TE E E+++P + Y + LG G+FG V + Sbjct: 36 WAARGSRSREPSP-KTEDNEGVLLT-EKLKPVDYEYREEVHWATHQLRLGRGSFGEVHR- 92 Query: 389 YYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWM-LV 447 + K+ AVK ++ E +EL+A A L +P IV + G W+ + Sbjct: 93 -MEDKQTGFQCAVKKVRLEVFR---AEELMACAG----LTSPRIVPLYGAVREGPWVNIF 144 Query: 448 MEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQ-H 506 ME+ E G L + +++ + + + + Q G++YL +H D+ A NVLL + Sbjct: 145 MELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGS 204 Query: 507 YAKISDF---------GLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWS 557 +A + DF GL K L + +TH APE + +K DVWS Sbjct: 205 HAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETH-------MAPEVVLGRSCDAKVDVWS 257 Query: 558 FGVLM 562 +M Sbjct: 258 SCCMM 262 >5FG8-A nrPDB Length = 285 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 48/195 (24%), Positives = 91/195 (46%), Gaps = 13/195 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +ELG G F VK+ K A KI+ + +L EA + ++L +P IVR Sbjct: 20 EELGKGAFSIVKRCV--QKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVR 77 Query: 435 MIGICEAESW-MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + + E++ LV ++ G L + + + + + Q+ + + ++ VHR Sbjct: 78 LHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHR 137 Query: 494 DLAARNVLLVTQ---HYAKISDFGLSKALRADENYY--KAQTHGKWPVKWYAPECINYYK 548 DL N+LL ++ K++DFGL+ ++ D + A T G + +PE + Sbjct: 138 DLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPG-----YLSPEVLKKEP 192 Query: 549 FSSKSDVWSFGVLMW 563 + D+W+ GV+++ Sbjct: 193 YGKSVDIWACGVILY 207 >1PHK-A nrPDB Length = 298 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 60/234 (25%), Positives = 107/234 (45%), Gaps = 23/234 (9%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILK-------NEANDPALKDELLAEANVMQQLD- 428 LG G V++ + K K AVKI+ + L++ L E ++++++ Sbjct: 25 LGRGVSSVVRRCIH--KPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDILRKVSG 82 Query: 429 NPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 487 +P I+++ E ++ LV ++ + G L YL + + +K +++ + + L + Sbjct: 83 HPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEVICALHK 142 Query: 488 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI--- 544 N VHRDL N+LL K++DFG S L E K + P + APE I Sbjct: 143 LNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGE---KLREVCGTP-SYLAPEIIECS 198 Query: 545 ---NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE-RMGCP 594 N+ + + D+WS GV+M+ + G P+ K + M+ G + G P Sbjct: 199 MNDNHPGYGKEVDMWSTGVIMYTLLA-GSPPFWHRKQMLMLRMIMSGNYQFGSP 251 >1TKI-A nrPDB Length = 321 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 59/236 (25%), Positives = 108/236 (45%), Gaps = 24/236 (10%) Query: 361 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 420 KE+Y K + ED LG G FG V + K KT K +K + D L + ++ Sbjct: 1 KELY--EKYMIAED--LGRGEFGIVHRCVETSSK--KTYMAKFVKVKGTDQVLVKKEISI 54 Query: 421 ANVMQQLDNPYIVRMIGICEAESWM--LVMEMAELGPLNKYLQQNR---HVKDKNIIELV 475 N+ + + ++ + E+ M LVM + L+ + + N + ++ I+ V Sbjct: 55 LNIARHRN------ILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYV 108 Query: 476 HQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA--KISDFGLSKALRADENYYKAQTHGK 533 HQV +++L N H D+ N++ T+ + KI +FG ++ L+ +N+ T Sbjct: 109 HQVCEALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFT--- 165 Query: 534 WPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 ++YAPE + S+ +D+WS G L++ S G P+ ++ + E Sbjct: 166 -APEYYAPEVHQHDVVSTATDMWSLGTLVYVLLS-GINPFLAETNQQIIENIMNAE 219 >3VN9-A nrPDB Length = 340 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 66/259 (25%), Positives = 117/259 (45%), Gaps = 26/259 (10%) Query: 376 ELGSGNFGTVKKGYYQMKKVV--KTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 ELG G +G V+K M+ V + +AVK ++ N K L+ M+ +D P+ V Sbjct: 58 ELGRGAYGVVEK----MRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTV 113 Query: 434 RMIGIC--EAESWMLVMEMAELGPLNKYLQQ----NRHVKDKNIIELVHQVSMGMKYLEE 487 G E + W + ME+ + L+K+ +Q + + + + ++ + +++L Sbjct: 114 TFYGALFREGDVW-ICMELMDTS-LDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS 171 Query: 488 S-NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI-- 544 + +HRD+ NVL+ K+ DFG+S L ++ K G P + APE I Sbjct: 172 KLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV--DSVAKTIDAGCKP--YMAPERINP 227 Query: 545 --NYYKFSSKSDVWSFGVLMWEAFSYGQKPYR--GMKGSEVTAMLEKGERMGCPAGCPRE 600 N +S KSD+WS G+ M E + + PY G ++ ++E+ E Sbjct: 228 ELNQKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAE 286 Query: 601 MYDLMNLCWTYDVENRPGF 619 D + C + + RP + Sbjct: 287 FVDFTSQCLKKNSKERPTY 305 >1V0B-A nrPDB Length = 288 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 50/222 (22%), Positives = 102/222 (45%), Gaps = 11/222 (4%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +++G G +G V Y +T A+K ++ E D + + E +++++L + IV+ Sbjct: 8 EKIGEGTYGVV---YKAQNNYGETFALKKIRLEKEDEGIPSTTIREISILKELKHSNIVK 64 Query: 435 MIGICEAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHR 493 + + + ++++ L K L ++ + Q+ G+ Y + +HR Sbjct: 65 LYDVIHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRRVLHR 124 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI-NYYKFSSK 552 DL +N+L+ + KI+DFGL++A Y + W + AP+ + K+S+ Sbjct: 125 DLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLW---YRAPDVLMGSKKYSTT 181 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP 594 D+WS G + E + G + G+ SE ++ +G P Sbjct: 182 IDIWSVGCIFAEMVN-GAPLFPGV--SEADQLMRIFRILGTP 220 >6NT9-A nrPDB Length = 742 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 60/241 (24%), Positives = 109/241 (45%), Gaps = 22/241 (9%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 LG G V +G + KK A+K+ N + + D + E V+++L++ IV++ Sbjct: 15 LGQGATANVFRGRH--KKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLF 71 Query: 437 GICEAESW---MLVMEMAELGPLNKYLQQNRH---VKDKNIIELVHQVSMGMKYLEESNF 490 I E + +L+ME G L L++ + + + + ++ V GM +L E+ Sbjct: 72 AIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGI 131 Query: 491 VHRDLAARNVLLVT----QHYAKISDFGLSKALRADENYYKAQ-THGKWPVKWYAPECI- 544 VHR++ N++ V Q K++DFG ++ L DE + T Y + Sbjct: 132 VHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLR 191 Query: 545 --NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKG----SEVTAMLEKGERMGCPAGCP 598 + K+ + D+WS GV + A + G P+R +G EV + G+ G +G Sbjct: 192 KDHQKKYGATVDLWSIGVTFYHA-ATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQ 250 Query: 599 R 599 + Sbjct: 251 K 251 >5G6V-A nrPDB Length = 324 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 49/193 (25%), Positives = 91/193 (47%), Gaps = 12/193 (6%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 +LG G + TV KG ++ + + L++E P + E ++++ L + IV + Sbjct: 9 KLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTA---IREVSLLKDLKHANIVTL 65 Query: 436 IGICEAE-SWMLVMEMAELGPLNKYLQQNRHVKDKNIIEL-VHQVSMGMKYLEESNFVHR 493 I E S LV E + L +YL ++ + + ++L + Q+ G+ Y +HR Sbjct: 66 HDIIHTEKSLTLVFEYLD-KDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHR 124 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI--NYYKFSS 551 DL +N+L+ + K++DFGL++A Y + WY P I +S+ Sbjct: 125 DLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEV----VTLWYRPPDILLGSTDYST 180 Query: 552 KSDVWSFGVLMWE 564 + D+W G + +E Sbjct: 181 QIDMWGVGCIFYE 193 >2HW6-A nrPDB Length = 307 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 52/224 (23%), Positives = 99/224 (44%), Gaps = 19/224 (8%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLD-NP 430 L + LG G + V+ G ++ K AVKI++ +A + + E + Q N Sbjct: 16 LTSELLGEGAYAKVQ-GAVSLQNG-KEYAVKIIEKQAGHS--RSRVFREVETLYQCQGNK 71 Query: 431 YIVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 I+ +I E ++ + LV E + G + ++Q+ +H ++ +V V+ + +L Sbjct: 72 NILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKG 131 Query: 490 FVHRDLAARNVLLVTQHY---AKISDFGLSKALRADENYYKAQ----THGKWPVKWYAPE 542 HRDL N+L + KI DF L ++ + + T ++ APE Sbjct: 132 IAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPE 191 Query: 543 CINYYK-----FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 + + + + D+WS GV+++ S G P+ G G++ Sbjct: 192 VVEVFTDQATFYDKRCDLWSLGVVLYIMLS-GYPPFVGHCGADC 234 >4C0T-A nrPDB Length = 974 Score = 59.3 bits (142), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 70/325 (21%), Positives = 141/325 (43%), Gaps = 36/325 (11%) Query: 332 ADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLED----KELGSGNFGTVKK 387 D+ P+ E L + E +E A + I+ + + + D KELG G++ TV Sbjct: 225 TDEIPKSETLKQNEENWEKKGAAVKTIKTMDGEMKTIRRNVTDFKFGKELGEGSYSTV-- 282 Query: 388 GYYQMKKVV-KTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC------E 440 K+ K AVK+L +K++ + N+ + N R+ I + Sbjct: 283 -ILATDKITGKQYAVKVLDKRH---IIKEKKVKYVNIEKHALNRLSNRLGVISLYFTFQD 338 Query: 441 AESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNV 500 +S V++ A G L +++ + ++ Q+ +KY+ ++ +HRDL N+ Sbjct: 339 KDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIKYMHDNGVIHRDLKPENI 398 Query: 501 LLVTQHYAKISDFGLSKAL--RADEN-YYKAQTHGKWPV---KWYAPECINYYKFSSKSD 554 LL + +I+DFG ++ L + DE+ Y K V ++ +PE + D Sbjct: 399 LLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVSPELLENKYCGKPGD 458 Query: 555 VWSFGVLMWEAFSYGQKPYRG----MKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWT 610 VW+FG ++++ + G+ P++ + ++T + + AG P + DL+ Sbjct: 459 VWAFGCIIYQMIA-GKPPFKATNEYLTFQKITKL-----QFAFSAGFPTIIRDLIKKILV 512 Query: 611 YDVENRPGFAAVELRLRNYYYDVVN 635 R ++ ++Y++ V+ Sbjct: 513 LQPSRRATIPEIQ---KHYFFQSVD 534 >3HKO-A nrPDB Length = 345 Score = 59.3 bits (142), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 63/259 (24%), Positives = 106/259 (40%), Gaps = 54/259 (20%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEAN--DPALKDELLAEANVMQQLDNPYIV 433 +G G++G V+ + ++ A+KI+ KN+ +P + + E +M++L +P I Sbjct: 34 IGQGSYGVVRVAIENQTRAIR--AIKIMNKNKIRQINPKDVERIKTEVRLMKKLHHPNIA 91 Query: 434 RMIGICEAESWM-LVMEMAE----LGPLNKYLQQ-------------------------N 463 R+ + E E ++ LVME+ L LN ++ N Sbjct: 92 RLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECNEEAIN 151 Query: 464 RHV-----------KDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHY--AKI 510 + ++K I ++ Q+ + YL HRD+ N L T K+ Sbjct: 152 GSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKSFEIKL 211 Query: 511 SDFGLSKALRADEN--YYKAQTHGKWPVKWYAPECINYYK--FSSKSDVWSFGVLMWEAF 566 DFGLSK N YY T P + APE +N + K D WS GVL+ Sbjct: 212 VDFGLSKEFYKLNNGEYYGMTTKAGTPY-FVAPEVLNTTNESYGPKCDAWSAGVLL-HLL 269 Query: 567 SYGQKPYRGMKGSEVTAML 585 G P+ G+ ++ + + Sbjct: 270 LMGAVPFPGVNDADTISQV 288 >4BGQ-A nrPDB Length = 304 Score = 58.9 bits (141), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 49/201 (24%), Positives = 90/201 (44%), Gaps = 8/201 (3%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G G +G V K + K+ + VA+K K+ + +K+ L E +++ L IV + Sbjct: 20 VGEGAYGVVLKCRH--KETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELK 77 Query: 437 GICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDL 495 + LV E E L + V + + ++Q+ + + +++ VHRD+ Sbjct: 78 EAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDI 137 Query: 496 AARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECINYYKFSSKSD 554 N+L+ K+ DFG ++ L N A + +WY +PE + + D Sbjct: 138 KPENLLISHNDVLKLCDFGFARNLSEGNN---ANYDEEVATRWYRSPELLLGAPYGKSVD 194 Query: 555 VWSFGVLMWEAFSYGQKPYRG 575 +WS G ++ E S GQ + G Sbjct: 195 MWSVGCILGE-LSDGQPLFPG 214 >2OU7-A nrPDB Length = 335 Score = 58.9 bits (141), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 51/221 (23%), Positives = 95/221 (42%), Gaps = 20/221 (9%) Query: 377 LGSGNFGTV-------KKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDN 429 LG G F K + K V K++ +K P ++++ E ++ + L + Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLK--------PHQREKMSMEISIHRSLAH 100 Query: 430 PYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 ++V G E ++ +V+E+ L + ++ + + + + Q+ +G +YL + Sbjct: 101 QHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRN 160 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 +HRDL N+ L KI DFGL+ + D K + APE ++ Sbjct: 161 RVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTP---NYIAPEVLSKKG 217 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 S + DVWS G +M+ G+ P+ E ++K E Sbjct: 218 HSFEVDVWSIGCIMY-TLLVGKPPFETSCLKETYLRIKKNE 257 >4H1O-A nrPDB Length = 560 Score = 58.9 bits (141), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 68/247 (27%), Positives = 101/247 (40%), Gaps = 72/247 (29%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74 +F NIT EAE+ L+ G+ DG +L R S++ G F LSV H I+ G Y Sbjct: 27 WFHPNITGVEAENLLLTRGV-DGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQ-NTGGYY 84 Query: 75 AIAGGRTHASPADLCHY----HSQ--ESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLI 128 + GG A+ A+L Y H Q E +G V LK P N Sbjct: 85 DLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLN-------------------- 124 Query: 129 REYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKT 188 P E+ WFHG +S +E+E+++ K Sbjct: 125 --------------------CADPTSER-----------WFHGHLSGKEAEKLLTEKGK- 152 Query: 189 NGKFLIR-ARDNNGSYALCLLH----------EGKVLHYRIDKDKTGKLSIPEGKKFDTL 237 +G FL+R ++ + G + L + + KV H I + + K + G++FD+L Sbjct: 153 HGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMI-RCQELKYDVGGGERFDSL 211 Query: 238 WQLVEHY 244 LVEHY Sbjct: 212 TDLVEHY 218 Score = 42.4 bits (98), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 35/109 (32%), Positives = 54/109 (49%), Gaps = 18/109 (16%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHG----------RKAHHY 64 +F G+++ +EAE L + G G +L+R+S+++ G F LSV G K H Sbjct: 133 WFHGHLSGKEAEKLLTEKG-KHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHV 191 Query: 65 TIE-RELNGTYAIAGGRTHASPADLCHYHSQ----ESDGLVCLLKKPFN 108 I +EL Y + GG S DL ++ + E+ G V LK+P N Sbjct: 192 MIRCQELK--YDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLN 238 >1JNK-A nrPDB Length = 423 Score = 58.5 bits (140), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 66/258 (25%), Positives = 114/258 (44%), Gaps = 28/258 (10%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K +GSG G V Y + + + VA+K L + E +M+ +++ I+ Sbjct: 68 KPIGSGAQGIVCAAYDAV--LDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS 125 Query: 435 MIGIC-------EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 487 ++ + E + LVME+ + L + +Q + + + L++Q+ G+K+L Sbjct: 126 LLNVFTPQKTLEEFQDVYLVMELMDAN-LCQVIQM--ELDHERMSYLLYQMLCGIKHLHS 182 Query: 488 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY--APECIN 545 + +HRDL N+++ + KI DFGL++ A ++ + V Y APE I Sbjct: 183 AGIIHRDLKPSNIVVKSDCTLKILDFGLART--AGTSFMMT----PYVVTRYYRAPEVIL 236 Query: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG-ERMGCPAGCPREMYDL 604 + D+WS G +M E + G + K E++G P CP M L Sbjct: 237 GMGYKENVDIWSVGCIMGEMVRHKIL----FPGRDYIDQWNKVIEQLGTP--CPEFMKKL 290 Query: 605 MNLCWTYDVENRPGFAAV 622 Y VENRP +A + Sbjct: 291 QPTVRNY-VENRPKYAGL 307 >3OHT-A nrPDB Length = 389 Score = 58.5 bits (140), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 49/199 (24%), Positives = 94/199 (47%), Gaps = 18/199 (9%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +GSG +G+V Y +K +K +AVK L E +++ + + ++ ++ Sbjct: 59 VGSGAYGSVCSSY-DVKSGLK-IAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLL 116 Query: 437 GI----CEAESWMLVMEMAEL--GPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 + E + V + L LN ++ + + D ++ L++Q+ G+KY+ ++ Sbjct: 117 DVFTPATSLEEFNDVYLVTHLMGADLNNIVKCQK-LTDDHVQFLIYQILRGLKYIHSADI 175 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APEC-INYYK 548 +HRDL N+ + KI DFGL++ + Y A +WY APE +N+ Sbjct: 176 IHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVA-------TRWYRAPEIMLNWMH 228 Query: 549 FSSKSDVWSFGVLMWEAFS 567 ++ D+WS G +M E + Sbjct: 229 YNMTVDIWSVGCIMAELLT 247 >3FME-A nrPDB Length = 290 Score = 58.5 bits (140), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 67/259 (25%), Positives = 116/259 (44%), Gaps = 26/259 (10%) Query: 376 ELGSGNFGTVKKGYYQMKKVV--KTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 ELG G +G V+K M+ V + +AVK ++ N K L+ M+ +D P+ V Sbjct: 14 ELGRGAYGVVEK----MRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTV 69 Query: 434 RMIGIC--EAESWMLVMEMAELGPLNKYLQQ----NRHVKDKNIIELVHQVSMGMKYLEE 487 G E + W + ME+ + L+K+ +Q + + + + ++ + +++L Sbjct: 70 TFYGALFREGDVW-ICMELMDTS-LDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS 127 Query: 488 S-NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI-- 544 + +HRD+ NVL+ K+ DFG+S L D K G P + APE I Sbjct: 128 KLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDD--VAKDIDAGCKP--YMAPERINP 183 Query: 545 --NYYKFSSKSDVWSFGVLMWEAFSYGQKPYR--GMKGSEVTAMLEKGERMGCPAGCPRE 600 N +S KSD+WS G+ M E + + PY G ++ ++E+ E Sbjct: 184 ELNQKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAE 242 Query: 601 MYDLMNLCWTYDVENRPGF 619 D + C + + RP + Sbjct: 243 FVDFTSQCLKKNSKERPTY 261 >2BRG-A nrPDB Length = 297 Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 49/199 (24%), Positives = 91/199 (45%), Gaps = 7/199 (3%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 LG G +G V+ ++ + V + +K + P + + E + + L++ +V+ Sbjct: 15 LGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCP---ENIKKEICINKMLNHENVVKFY 71 Query: 437 G-ICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDL 495 G E L +E G L ++ + + + + HQ+ G+ YL HRD+ Sbjct: 72 GHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDI 131 Query: 496 AARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKS-D 554 N+LL + KISDFGL+ R + N + + + APE + +F ++ D Sbjct: 132 KPENLLLDERDNLKISDFGLATVFRYN-NRERLLNKMCGTLPYVAPELLKRREFHAEPVD 190 Query: 555 VWSFGVLMWEAFSYGQKPY 573 VWS G+++ A G+ P+ Sbjct: 191 VWSCGIVL-TAMLAGELPW 208 >4J52-A nrPDB Length = 293 Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 51/221 (23%), Positives = 95/221 (42%), Gaps = 20/221 (9%) Query: 377 LGSGNFGTV-------KKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDN 429 LG G F K + K V K++ +K P ++++ E ++ + L + Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLK--------PHQREKMSMEISIHRSLAH 73 Query: 430 PYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 ++V G E ++ +V+E+ L + ++ + + + + Q+ +G +YL + Sbjct: 74 QHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRN 133 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 +HRDL N+ L KI DFGL+ + D K + APE ++ Sbjct: 134 RVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTP---NYIAPEVLSKKG 190 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 S + DVWS G +M+ G+ P+ E ++K E Sbjct: 191 HSFEVDVWSIGCIMY-TLLVGKPPFETSCLKETYLRIKKNE 230 >1CM8-A nrPDB Length = 367 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 36/118 (30%), Positives = 65/118 (55%), Gaps = 10/118 (8%) Query: 460 LQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL 519 L ++ + + I LV+Q+ G++Y+ + +HRDL N+ + KI DFGL++ Sbjct: 119 LMKHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLAR-- 176 Query: 520 RADENYYKAQTHGKWPVKWY-APECI-NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG 575 +AD ++ G +WY APE I N+ +++ D+WS G +M E + G+ ++G Sbjct: 177 QAD-----SEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKG 228 >2I6L-A nrPDB Length = 320 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 62/221 (28%), Positives = 98/221 (44%), Gaps = 30/221 (13%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K LG G G V K VA+K K DP L E ++++LD+ IV+ Sbjct: 17 KPLGCGGNGLVFSAVDN--DCDKRVAIK--KIVLTDPQSVKHALREIKIIRRLDHDNIVK 72 Query: 435 MIGICEAESWMLVMEMAELGPLNK-YLQQNRHVKD-KNIIE-----------LVHQVSMG 481 + I L ++ L LN Y+ Q D N++E ++Q+ G Sbjct: 73 VFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRG 132 Query: 482 MKYLEESNFVHRDLAARNVLLVTQHYA-KISDFGLSKALRADENY-YKAQTHGKWPVKWY 539 +KY+ +N +HRDL N+ + T+ KI DFGL++ + D +Y +K KWY Sbjct: 133 LKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIM--DPHYSHKGHLSEGLVTKWY 190 Query: 540 -APECI----NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG 575 +P + NY K D+W+ G + E + G+ + G Sbjct: 191 RSPRLLLSPNNYTK---AIDMWAAGCIFAEMLT-GKTLFAG 227 >3FI2-A nrPDB Length = 353 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 66/258 (25%), Positives = 114/258 (44%), Gaps = 28/258 (10%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K +GSG G V Y + + + VA+K L + E +M+ +++ I+ Sbjct: 30 KPIGSGAQGIVCAAYDAV--LDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS 87 Query: 435 MIGIC-------EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 487 ++ + E + LVME+ + L + +Q + + + L++Q+ G+K+L Sbjct: 88 LLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIQM--ELDHERMSYLLYQMLCGIKHLHS 144 Query: 488 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY--APECIN 545 + +HRDL N+++ + KI DFGL++ A ++ + V Y APE I Sbjct: 145 AGIIHRDLKPSNIVVKSDCTLKILDFGLART--AGTSFMMT----PYVVTRYYRAPEVIL 198 Query: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG-ERMGCPAGCPREMYDL 604 + D+WS G +M E + G + K E++G P CP M L Sbjct: 199 GMGYKENVDIWSVGCIMGEMVRHKIL----FPGRDYIDQWNKVIEQLGTP--CPEFMKKL 252 Query: 605 MNLCWTYDVENRPGFAAV 622 Y VENRP +A + Sbjct: 253 QPTVRNY-VENRPKYAGL 269 >3MDY-A nrPDB Length = 337 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 69/285 (24%), Positives = 121/285 (42%), Gaps = 54/285 (18%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K++G G +G V G ++ +KV AVK+ ++ + + +M+ + Sbjct: 43 KQIGKGRYGEVWMGKWRGEKV----AVKVFFTTEEASWFRETEIYQTVLMRHEN------ 92 Query: 435 MIGICEAE-----SWM---LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE 486 ++G A+ SW L+ + E G L YL+ + K++++L + G+ +L Sbjct: 93 ILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTT-LDAKSMLKLAYSSVSGLCHLH 151 Query: 487 ESNF--------VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKW 538 F HRDL ++N+L+ I+D GL+ +D N + + K Sbjct: 152 TEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKR 211 Query: 539 YAP-----ECINYYKFSS--KSDVWSFGVLMWE----AFSYG-----QKPYRGMKGSEVT 582 Y P E +N F S +D++SFG+++WE S G Q PY + S+ + Sbjct: 212 YMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPS 271 Query: 583 ------AMLEKGERMGCPAG-----CPREMYDLMNLCWTYDVENR 616 + K R P C R+M LM CW ++ +R Sbjct: 272 YEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASR 316 >2VD5-A nrPDB Length = 412 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 69/275 (25%), Positives = 117/275 (42%), Gaps = 26/275 (9%) Query: 352 YADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDP 411 +A+P +R KEV L R + K +G G F V +MK+ + A+KI+ D Sbjct: 45 WAEPIVVRLKEVRLQRDDFEIL-KVIGRGAFSEV--AVVKMKQTGQVYAMKIMNKW--DM 99 Query: 412 ALKDELLA---EANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQ-NRHV 466 + E+ E +V+ D +I ++ + E+++ LVME G L L + + Sbjct: 100 LKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERI 159 Query: 467 KDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYY 526 + + ++ M + + +VHRD+ N+LL + +++DFG LRAD Sbjct: 160 PAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVR 219 Query: 527 KAQTHGKWPVKWYAPECINYYKFSS-------KSDVWSFGVLMWEAFSYGQKPYRGMKGS 579 G + +PE + + D W+ GV +E F YGQ P+ + Sbjct: 220 SLVAVGT--PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMF-YGQTPFYADSTA 276 Query: 580 EVTA-MLEKGERMGCPA---GCPREMYDLMN--LC 608 E ++ E + P G P E D + LC Sbjct: 277 ETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLC 311 >4G3E-A nrPDB Length = 352 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 54/200 (27%), Positives = 87/200 (43%), Gaps = 33/200 (16%) Query: 377 LGSGNFGTV---KKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 +G G+FG V K + VK V +++ + E EL+A A L +P IV Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVE--------ELVACAG----LSSPRIV 129 Query: 434 RMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 + G W+ + ME+ E G L + ++Q + + + + Q G++YL +H Sbjct: 130 PLYGAVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILH 189 Query: 493 RDLAARNVLLVTQ-HYAKISDF---------GLSKALRADENYYKAQTHGKWPVKWYAPE 542 D+ A NVLL + A + DF GL K+L + +TH APE Sbjct: 190 GDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETH-------MAPE 242 Query: 543 CINYYKFSSKSDVWSFGVLM 562 + +K D+WS +M Sbjct: 243 VVMGKPCDAKVDIWSSCCMM 262 >4PWN-A nrPDB Length = 274 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 57/208 (27%), Positives = 96/208 (46%), Gaps = 16/208 (7%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 D E+G G+F TV KG V VA L++ + + EA +++ L +P IV Sbjct: 15 DIEIGRGSFKTVYKGLDTETTV--EVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIV 72 Query: 434 RMIGICEA-----ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 R E+ + +LV E+ G L YL++ + +K K + Q+ G+++L Sbjct: 73 RFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTR 132 Query: 489 N--FVHRDLAARNVLLV-TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 +HRDL N+ + KI D GL+ L ++ K+ ++ APE + Sbjct: 133 TPPIIHRDLKCDNIFITGPTGSVKIGDLGLA-TLEKRASFAKSVIGTP---EFMAPE-MY 187 Query: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPY 573 K+ DV++FG+ M E + + PY Sbjct: 188 EEKYDESVDVYAFGMCMLE-MATSEYPY 214 >2JC6-A nrPDB Length = 334 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 61/221 (27%), Positives = 100/221 (45%), Gaps = 20/221 (9%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEA---NDPALKDELLAEANVMQQLDNPYIV 433 LG+G F V + K K AVK + +A + ++++E+ V++++ + IV Sbjct: 30 LGTGAFSEVVLA--EEKATGKLFAVKCIPKKALKGKESSIENEIA----VLRKIKHENIV 83 Query: 434 RMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 + I E+ + + LVM++ G L + + +K+ L+ QV + YL VH Sbjct: 84 ALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVH 143 Query: 493 RDLAARNVLLVTQHYAK---ISDFGLSKAL-RADENYYKAQTHGKWPVKWYAPECINYYK 548 RDL N+L +Q ISDFGLSK + D T G + APE + Sbjct: 144 RDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPG-----YVAPEVLAQKP 198 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 +S D WS GV+ + G P+ S++ + K E Sbjct: 199 YSKAVDCWSIGVIAYILLC-GYPPFYDENDSKLFEQILKAE 238 >6BXI-A nrPDB Length = 333 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 70/307 (22%), Positives = 126/307 (41%), Gaps = 45/307 (14%) Query: 370 LTLED----KELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVM 424 L LED K +G G FG V+ Q K A+KIL K + + + AE +++ Sbjct: 3 LGLEDFESLKVIGRGAFGEVR--LVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDIL 60 Query: 425 QQLDNPYIVRMI-GICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMK 483 + D+ ++V+M + + L+ME G + L + + ++ + + + + Sbjct: 61 VEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAID 120 Query: 484 YLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADE--NYYKAQTHG--------- 532 + + F+HRD+ N+LL ++ + K+SDFGL L+ +Y+ H Sbjct: 121 SIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQN 180 Query: 533 --------KWPVK-------------WYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQK 571 W + APE ++ D WS GV+M+E G Sbjct: 181 MNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEML-IGYP 239 Query: 572 PYRGMKGSEV-TAMLEKGERMGCPAGCP--REMYDLMNLCWTYDVENRPGFAAVELRLRN 628 P+ E ++ E + P P + DL+ L + + E+R G VE N Sbjct: 240 PFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLI-LRFCCEWEHRIGAPGVEEIKSN 298 Query: 629 YYYDVVN 635 +++ V+ Sbjct: 299 SFFEGVD 305 >4PL5-B nrPDB Length = 435 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 56/208 (26%), Positives = 93/208 (44%), Gaps = 20/208 (9%) Query: 377 LGSGNFGT-VKKGYYQMKKVVKTVAVKILKNEANDPALKD-ELLAEANVMQQLDNPYIVR 434 LG G GT V KG + + V AVK + E A ++ +LL E++ ++P ++R Sbjct: 35 LGHGAEGTIVYKGMFDNRDV----AVKRILPECFSFADREVQLLRESD-----EHPNVIR 85 Query: 435 MIGICEAESWMLVMEMAELGPLNKYLQQNRHVK-DKNIIELVHQVSMGMKYLEESNFVHR 493 + + + L +Y++Q I L+HQ + G+ +L N VHR Sbjct: 86 YFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGLAHLHSLNIVHR 145 Query: 494 DLAARNVLLVTQHY-----AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 DL N+LL + A ISDFGL K L + + ++ W APE ++ Sbjct: 146 DLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDC 205 Query: 549 FSSKS---DVWSFGVLMWEAFSYGQKPY 573 + + D++S G + + S G P+ Sbjct: 206 KDNPTYTVDIFSAGCVFYYVISEGYHPF 233 >2EOB-A nrPDB Length = 124 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 30/82 (36%), Positives = 47/82 (57%), Gaps = 2/82 (2%) Query: 163 HEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDK 222 HE PW++ ++SR E+E + L+ +G FLIR R+ SYA+ GKV H RI++D Sbjct: 16 HESKPWYYDRLSRGEAEDM-LMRIPRDGAFLIRKREGTDSYAITFRARGKVKHCRINRDG 74 Query: 223 TGKLSIPEGKKFDTLWQLVEHY 244 + F++L +LV +Y Sbjct: 75 R-HFVLGTSAYFESLVELVSYY 95 >4MYG-A nrPDB Length = 372 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 54/208 (25%), Positives = 96/208 (46%), Gaps = 22/208 (10%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +GSG +G+V K+ + VA+K L E +++ + + ++ ++ Sbjct: 51 VGSGAYGSVCSAID--KRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLL 108 Query: 437 GICEAES-------WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 + S + LVM + L K + ++ I LV+Q+ G+KY+ + Sbjct: 109 DVFTPASSLRNFYDFYLVMPFMQTD-LQKIM--GMEFSEEKIQYLVYQMLKGLKYIHSAG 165 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECI-NYY 547 VHRDL N+ + KI DFGL++ AD A+ G +WY APE I ++ Sbjct: 166 VVHRDLKPGNLAVNEDCELKILDFGLAR--HAD-----AEMTGYVVTRWYRAPEVILSWM 218 Query: 548 KFSSKSDVWSFGVLMWEAFSYGQKPYRG 575 ++ D+WS G +M E + G+ ++G Sbjct: 219 HYNQTVDIWSVGCIMAEMLT-GKTLFKG 245 >4EWQ-A nrPDB Length = 383 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 30/104 (28%), Positives = 55/104 (52%), Gaps = 9/104 (8%) Query: 466 VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENY 525 + D ++ L++Q+ G+KY+ ++ +HRDL N+ + KI DFGL++ + Sbjct: 145 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-------H 197 Query: 526 YKAQTHGKWPVKWY-APEC-INYYKFSSKSDVWSFGVLMWEAFS 567 + G +WY APE +N+ ++ D+WS G +M E + Sbjct: 198 TDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT 241 >5AWM-A nrPDB Length = 394 Score = 56.2 bits (134), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 64/259 (24%), Positives = 112/259 (43%), Gaps = 32/259 (12%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 + +GSG G V Y + + + VA+K L + E +M+ +++ I+ Sbjct: 50 RPIGSGAQGIVCAAYDTITQ--QNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIG 107 Query: 435 MIG-------ICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 487 ++ + E + LVME+ + L + +Q + + + L++Q+ G+K+L Sbjct: 108 LLNAFTPQRNLEEFQDVYLVMELMD-ANLCQVIQMD--LDHDRMSYLLYQMLCGIKHLHS 164 Query: 488 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWP---VKWY-APEC 543 + +HRDL N+++ KI DFGL++ T P ++Y APE Sbjct: 165 AGIIHRDLKPSNIVVKADCTLKILDFGLART--------AGTTFMMTPYVVTRYYRAPEV 216 Query: 544 INYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK-GERMGCPAGCPREMY 602 I ++ D+WS G +M E G G++ K E++G P+ P M Sbjct: 217 ILGMGYTENVDIWSVGCIMGEMIRGGVL----FPGTDHIDQWNKIIEQLGTPS--PSFMQ 270 Query: 603 DLMNLCWTYDVENRPGFAA 621 L Y VENRP + Sbjct: 271 RLQPTVRNY-VENRPRYTG 288 >3UIM-A nrPDB Length = 326 Score = 56.2 bits (134), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 53/205 (25%), Positives = 94/205 (45%), Gaps = 15/205 (7%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 LG G FG V KG +V AVK LK E + + E ++ + ++R+ Sbjct: 38 LGRGGFGKVYKGRLADGTLV---AVKRLKEERTQGG-ELQFQTEVEMISMAVHRNLLRLR 93 Query: 437 GICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMG----MKYLEES--- 488 G C + +LV G + L++ + ++++G + YL + Sbjct: 94 GFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYLHDHCDP 153 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 +HRD+ A N+LL + A + DFGL+K + + + G + APE ++ K Sbjct: 154 KIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRG--TIGHIAPEYLSTGK 211 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPY 573 S K+DV+ +GV++ E + GQ+ + Sbjct: 212 SSEKTDVFGYGVMLLELIT-GQRAF 235 >5U06-A nrPDB Length = 120 Score = 55.8 bits (133), Expect = 5e-08, Method: Composition-based stats. Identities = 33/94 (35%), Positives = 52/94 (55%), Gaps = 4/94 (4%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTI---ERELN 71 +F G I+REE++ + Q G+ DGL+L+R+S+ GF LS+ H +K HY I E E Sbjct: 19 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 78 Query: 72 GTYAIAGGRTHASP-ADLCHYHSQESDGLVCLLK 104 +++ G+T + L +H L CLL+ Sbjct: 79 LYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLR 112 Score = 55.5 bits (132), Expect = 6e-08, Method: Composition-based stats. Identities = 38/107 (35%), Positives = 59/107 (55%), Gaps = 6/107 (5%) Query: 158 IATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHY 216 ++ H WFHG+ISREES++++ +G FL+R ++ N + L L H KV HY Sbjct: 9 LSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHY 68 Query: 217 RI-DKDKTGKL--SIPEGK-KFDTLWQLVEHYSYKADGLLRVLTVPC 259 I ++ G+L S+ +G+ +F L QLVE + G+L L C Sbjct: 69 LILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNR-GILPCLLRHC 114 >5UUU-A nrPDB Length = 547 Score = 55.8 bits (133), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 53/220 (24%), Positives = 97/220 (44%), Gaps = 22/220 (10%) Query: 370 LTLED----KELGSGNFGTVKKGYYQMKKVV--KTVAVKILKNEANDPALKDELLAEANV 423 LT+ D + +G G FG V Y +K K A+K L + + L + Sbjct: 195 LTMNDFSVHRIIGRGGFGEV----YGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERI 250 Query: 424 MQQL----DNPYIVRM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQV 478 M L D P+IV M + ++++ G L+ +L Q+ + ++ ++ Sbjct: 251 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEI 310 Query: 479 SMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKW 538 +G++++ V+RDL N+LL + +ISD GL+ + + THG + Sbjct: 311 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----Y 365 Query: 539 YAPECINY-YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMK 577 APE + + S +D +S G ++++ G P+R K Sbjct: 366 MAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHK 404 >4O2Z-A nrPDB Length = 377 Score = 55.8 bits (133), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 35/119 (29%), Positives = 61/119 (51%), Gaps = 8/119 (6%) Query: 456 LNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGL 515 +N L+ + +++ ++ V+Q+ G+KYL +N HRDL N++ KI DFGL Sbjct: 137 MNVVLRSRQVLEESHMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGL 196 Query: 516 SKALRADENYYKAQTHGKWPVKWYAPE--CINYYKFSSKSDVWSFGVLMWEAFSYGQKP 572 S+++ D Y + + +WY P + +S+ D+WS G + E Y +KP Sbjct: 197 SRSV--DVPYSELTDYVI--TRWYRPPELLLENTNYSTAVDIWSVGCIFAEM--YNRKP 249 >3C51-A nrPDB Length = 543 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 55/216 (25%), Positives = 103/216 (47%), Gaps = 13/216 (6%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE-LLAEANVMQQLDNP 430 L+ + LG G FG V QMK K A K L + + + E ++ ++ + Sbjct: 188 LDFRVLGRGGFGEVFA--CQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSR 245 Query: 431 YIVRMIGICEAESWM-LVMEMAELGPLNKYL----QQNRHVKDKNIIELVHQVSMGMKYL 485 +IV + E ++ + LVM + G + ++ + N ++ I Q+ G+++L Sbjct: 246 FIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHL 305 Query: 486 EESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 + N ++RDL NVLL +ISD GL+ L+A + K + + P + APE + Sbjct: 306 HQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQT--KTKGYAGTP-GFMAPELLL 362 Query: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 ++ D ++ GV ++E + + P+R +G +V Sbjct: 363 GEEYDFSVDYFALGVTLYEMIA-ARGPFRA-RGEKV 396 >6CKI-A nrPDB Length = 316 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 41/166 (24%), Positives = 72/166 (43%), Gaps = 17/166 (10%) Query: 442 ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVL 501 + + LV E G + ++ + RH + +V V+ + +L HRDL N+L Sbjct: 84 DRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENIL 143 Query: 502 LVTQHY---AKISDFGLSKALRADENYYKAQT----HGKWPVKWYAPECINYYK-----F 549 + KI DFGL ++ + + T ++ APE + + + Sbjct: 144 CEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIY 203 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPA 595 + D+WS GV+++ S G P+ G GS+ ++GE CPA Sbjct: 204 DKRCDLWSLGVILYILLS-GYPPFVGRCGSDCG--WDRGE--ACPA 244 >2VN9-A nrPDB Length = 301 Score = 55.5 bits (132), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 49/196 (25%), Positives = 91/196 (46%), Gaps = 15/196 (7%) Query: 375 KELGSGNFGTVKKGYYQMK-KVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 +ELG G F V++ MK + A KI+ + +L EA + + L +P IV Sbjct: 10 EELGKGAFSVVRRC---MKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIV 66 Query: 434 RM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 R+ I E LV ++ G L + + + + + + Q+ + + + VH Sbjct: 67 RLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVH 126 Query: 493 RDLAARNVLLVTQH---YAKISDFGLSKALRADENYY--KAQTHGKWPVKWYAPECINYY 547 RDL N+LL ++ K++DFGL+ ++ D+ + A T G + +PE + Sbjct: 127 RDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPG-----YLSPEVLRKD 181 Query: 548 KFSSKSDVWSFGVLMW 563 + D+W+ GV+++ Sbjct: 182 PYGKPVDMWACGVILY 197 >6BFN-A nrPDB Length = 342 Score = 55.5 bits (132), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 55/218 (25%), Positives = 99/218 (45%), Gaps = 28/218 (12%) Query: 373 EDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEAND--PALKDELLAEANVMQQLDNP 430 E+ ++G G FG V + M+ V AVK LK A+ A+K L E + + +P Sbjct: 26 EELKIGEGGFGCVYRAV--MRNTV--YAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHP 81 Query: 431 YIVRMIGICEAESWMLVMEMAELGPL-NKYLQQNRHVKDKNI--------IELVHQVSMG 481 IV G C + ++ G L N L+ H + + ++++ + Sbjct: 82 NIVDFAGYCAQNGFYCLV----YGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARA 137 Query: 482 MKYLEESN--FVHRDLAARNVLLVTQHYAKISDFGLSKALR-----ADENYYKAQTHGKW 534 +++L + + +H D+ + NVLL + K+ DFGL++ R ++ A+T Sbjct: 138 IQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVR 197 Query: 535 PVKWYAP-ECINYYKFSSKSDVWSFGVLMWEAFSYGQK 571 Y P E I + + +D +SFGV++ E + GQ+ Sbjct: 198 GTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLA-GQR 234 >1NRV-A nrPDB Length = 105 Score = 55.1 bits (131), Expect = 9e-08, Method: Composition-based stats. Identities = 32/87 (36%), Positives = 49/87 (56%), Gaps = 5/87 (5%) Query: 163 HEKMPWFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHYRI--- 218 H WFHG+ISREES +I+ +G FL+R ++ N ++ L L H K+ +++I Sbjct: 2 HRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPC 61 Query: 219 DKDKTGKLSIPEGK-KFDTLWQLVEHY 244 + D S+ +G KF L QLV+ Y Sbjct: 62 EDDGQTFFSLDDGNTKFSDLIQLVDFY 88 Score = 44.7 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 20/52 (38%), Positives = 33/52 (63%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTI 66 +F G I+REE+ + Q G+ DGL+LLR S++ F L++ H +K ++ I Sbjct: 7 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQI 58 >4LQP-A nrPDB Length = 508 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 44/157 (28%), Positives = 76/157 (48%), Gaps = 6/157 (3%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVK-ILKNEANDPALKDELLAEANVMQQLDNPYIV 433 K +G G FG V+ Q K K A+K +LK+E + AE +V+ D+P++V Sbjct: 108 KVIGKGAFGEVR--LVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSPWVV 165 Query: 434 RMI-GICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 + +A+ L+ME G L L + + + + + + ++ + + F+H Sbjct: 166 SLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKLGFIH 225 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRA--DENYYK 527 R + N+L+ + + K+SDFGLS D NYYK Sbjct: 226 RAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYK 262 >3E7O-A nrPDB Length = 360 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 64/259 (24%), Positives = 114/259 (44%), Gaps = 30/259 (11%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K +GSG G V + + + VAVK L + E +++ +++ I+ Sbjct: 28 KPIGSGAQGIVCAAFDTVLGI--NVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIIS 85 Query: 435 MIGIC-------EAESWMLVMEMAELGPLNKYLQQNRHVK--DKNIIELVHQVSMGMKYL 485 ++ + E + LVME+ ++ L Q H++ + + L++Q+ G+K+L Sbjct: 86 LLNVFTPQKTLEEFQDVYLVMEL-----MDANLCQVIHMELDHERMSYLLYQMLCGIKHL 140 Query: 486 EESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY--APEC 543 + +HRDL N+++ + KI DFGL++ A N+ + V Y APE Sbjct: 141 HSAGIIHRDLKPSNIVVKSDCTLKILDFGLART--ASTNFMMT----PYVVTRYYRAPEV 194 Query: 544 INYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYD 603 I + D+WS G +M E G ++G + + E++G P+ M Sbjct: 195 ILGMGYKENVDIWSVGCIMGELVK-GSVIFQG--TDHIDQWNKVIEQLGTPSA--EFMAA 249 Query: 604 LMNLCWTYDVENRPGFAAV 622 L Y VENRP + + Sbjct: 250 LQPTVRNY-VENRPAYPGI 267 >3PVW-A nrPDB Length = 695 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 53/223 (23%), Positives = 98/223 (43%), Gaps = 22/223 (9%) Query: 370 LTLED----KELGSGNFGTVKKGYYQMKKVV--KTVAVKILKNEANDPALKDELLAEANV 423 LT+ D + +G G FG V Y +K K A+K L + + L + Sbjct: 186 LTMNDFSVHRIIGRGGFGEV----YGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERI 241 Query: 424 MQQL----DNPYIVRM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQV 478 M L D P+IV M + ++++ G L+ +L Q+ + ++ ++ Sbjct: 242 MLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEI 301 Query: 479 SMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKW 538 +G++++ V+RDL N+LL + +ISD GL+ + + THG + Sbjct: 302 ILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----Y 356 Query: 539 YAPECINY-YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSE 580 APE + + S +D +S G ++++ G P+R K + Sbjct: 357 MAPEVLQKGVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKD 398 >4YHJ-A nrPDB Length = 584 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 49/206 (23%), Positives = 96/206 (46%), Gaps = 13/206 (6%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDEL-LAEANVMQQLDNPYIVRM 435 LG G FG V Q++ K A K L+ + + + L E +++++ + ++V + Sbjct: 193 LGKGGFGEV--CACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSL 250 Query: 436 IGICEA-ESWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 E ++ LV+ + G L ++ N ++ + ++ G++ L+ V+ Sbjct: 251 AYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVY 310 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKW-PVKWYAPECINYYKFSS 551 RDL N+LL + + +ISD GL+ + + + G+ V + APE +N K++ Sbjct: 311 RDLKPENILLDDRGHIRISDLGLATEIPEGQ-----RVRGRVGTVGYMAPEVVNNEKYTF 365 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMK 577 D W G L++E G P++ K Sbjct: 366 SPDWWGLGCLIYEMIQ-GHSPFKKYK 390 >3G2F-A nrPDB Length = 336 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 64/223 (28%), Positives = 96/223 (43%), Gaps = 33/223 (14%) Query: 368 KLLTLEDKELGSGNFGTVKKGYYQMKKV-VKTVAVKILKNEANDPAL-KDELLAEANVMQ 425 KLL L +G G +G V KG + V VK + +N N+ + + L+ N+ + Sbjct: 16 KLLEL----IGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIAR 71 Query: 426 QLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKD-KNIIELVHQVSMGMKY 484 + V G E ++LVME G L KYL + H D + L H V+ G+ Y Sbjct: 72 FIVGDERVTADGRME---YLLVMEYYPNGSLCKYL--SLHTSDWVSSCRLAHSVTRGLAY 126 Query: 485 LE---------ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADE-----NYYKAQT 530 L + HRDL +RNVL+ ISDFGLS L + A Sbjct: 127 LHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAI 186 Query: 531 HGKWPVKWYAPE----CINYYKFSS---KSDVWSFGVLMWEAF 566 +++ APE +N S + D+++ G++ WE F Sbjct: 187 SEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIF 229 >5U6Y-A nrPDB Length = 461 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 45/195 (23%), Positives = 89/195 (45%), Gaps = 13/195 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +ELG G F V++ + + A KI+ + +L EA + + L +P IVR Sbjct: 6 EELGKGAFSVVRRCVKVLAG--QEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVR 63 Query: 435 M-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + I E L+ ++ G L + + + + + + Q+ + + + VHR Sbjct: 64 LHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHR 123 Query: 494 DLAARNVLLVTQ---HYAKISDFGLSKALRADENYY--KAQTHGKWPVKWYAPECINYYK 548 DL N+LL ++ K++DFGL+ + ++ + A T G + +PE + Sbjct: 124 DLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPG-----YLSPEVLRKDP 178 Query: 549 FSSKSDVWSFGVLMW 563 + D+W+ GV+++ Sbjct: 179 YGKPVDLWACGVILY 193 >3UDB-A nrPDB Length = 317 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 57/195 (29%), Positives = 88/195 (45%), Gaps = 17/195 (8%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVK-ILKNEANDPALKDELLAEANVMQQLDNPYIV 433 K++G+GNFG + + K+ + VAVK I + E D +K E++ + L +P IV Sbjct: 25 KDIGAGNFGVAR--LMRDKQANELVAVKYIERGEKIDENVKREIINH----RSLRHPNIV 78 Query: 434 RMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 R + + + +VME A G L + + + Q+ G+ Y H Sbjct: 79 RFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYAHAMQVAH 138 Query: 493 RDLAARNVLL--VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECINYYKF 549 RDL N LL KI+DFG SKA + +Q Y APE + ++ Sbjct: 139 RDLKLENTLLDGSPAPRLKIADFGYSKA-----SVLHSQPKSAVGTPAYIAPEVLLKKEY 193 Query: 550 SSK-SDVWSFGVLMW 563 K +DVWS GV ++ Sbjct: 194 DGKVADVWSCGVTLY 208 >3UC3-A nrPDB Length = 361 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 54/194 (27%), Positives = 86/194 (44%), Gaps = 15/194 (7%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K++GSGNFG + ++ K + VAVK ++ A A+ + + E + L +P IVR Sbjct: 26 KDIGSGNFGVARLMRDKLTK--ELVAVKYIERGA---AIDENVQREIINHRSLRHPNIVR 80 Query: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + + + ++ME A G L + + + Q+ G+ Y HR Sbjct: 81 FKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHR 140 Query: 494 DLAARNVLL--VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECINYYKFS 550 DL N LL KI DFG SK+ + +Q Y APE + ++ Sbjct: 141 DLKLENTLLDGSPAPRLKICDFGYSKS-----SVLHSQPKSTVGTPAYIAPEVLLRQEYD 195 Query: 551 SK-SDVWSFGVLMW 563 K +DVWS GV ++ Sbjct: 196 GKIADVWSCGVTLY 209 >4M7I-A nrPDB Length = 299 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 53/220 (24%), Positives = 96/220 (43%), Gaps = 42/220 (19%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTV--AVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 LG G FG V ++ K V A+K ++ + A +++++ E + +L++P IVR Sbjct: 13 LGRGGFGVV----FEAKNKVDDCNYAIKRIRLPNRELA-REKVMREVKALAKLEHPGIVR 67 Query: 435 MIGICEAESWMLVMEMAELGP--------LNKYLQQNRHVKD----KNIIE--------- 473 +W+ +L P + L + ++KD + IE Sbjct: 68 YFN-----AWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLH 122 Query: 474 LVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQT--- 530 + Q++ +++L +HRDL N+ K+ DFGL A+ DE T Sbjct: 123 IFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMP 182 Query: 531 -----HGKWPVKWY-APECINYYKFSSKSDVWSFGVLMWE 564 G+ K Y +PE I+ +S K D++S G++++E Sbjct: 183 AYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFE 222 >2VZ6-A nrPDB Length = 313 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 45/195 (23%), Positives = 89/195 (45%), Gaps = 13/195 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +ELG G F V++ + + A KI+ + +L EA + + L +P IVR Sbjct: 28 EELGKGAFSVVRRCVKVLAG--QEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVR 85 Query: 435 M-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + I E L+ ++ G L + + + + + + Q+ + + + VHR Sbjct: 86 LHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHR 145 Query: 494 DLAARNVLLVTQ---HYAKISDFGLSKALRADENYY--KAQTHGKWPVKWYAPECINYYK 548 DL N+LL ++ K++DFGL+ + ++ + A T G + +PE + Sbjct: 146 DLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPG-----YLSPEVLRKDP 200 Query: 549 FSSKSDVWSFGVLMW 563 + D+W+ GV+++ Sbjct: 201 YGKPVDLWACGVILY 215 >3DLS-A nrPDB Length = 335 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 100/209 (47%), Gaps = 22/209 (10%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNE-------ANDPALKDELLAEANVMQQLDN 429 LGSG FG V + K K V VK +K E DP L L E ++ ++++ Sbjct: 32 LGSGAFGFVWTAVDKEKN--KEVVVKFIKKEKVLEDCWIEDPKLGKVTL-EIAILSRVEH 88 Query: 430 PYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVK-DKNIIE-LVHQVSMGMKYLE 486 I++++ I E + + LVME G L+ + +RH + D+ + + Q+ + YL Sbjct: 89 ANIIKVLDIFENQGFFQLVMEKHGSG-LDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLR 147 Query: 487 ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI-- 544 + +HRD+ N+++ K+ DFG + L + +Y +++ APE + Sbjct: 148 LKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGT----IEYCAPEVLMG 203 Query: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKPY 573 N Y+ + ++WS GV ++ + + P+ Sbjct: 204 NPYR-GPELEMWSLGVTLY-TLVFEENPF 230 >3REP-A nrPDB Length = 271 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 61/269 (22%), Positives = 107/269 (39%), Gaps = 25/269 (9%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424 +D K L K L + G + KG +Q +V VK+LK + E + Sbjct: 7 IDFKQLNFLTK-LNENHSGELWKGRWQGNDIV----VKVLKVRDWSTRKSRDFNEECPRL 61 Query: 425 QQLDNPYIVRMIGICE---AESWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVS 479 + +P ++ ++G C+ A L+ G L L + N V ++ ++ Sbjct: 62 RIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMA 121 Query: 480 MGMKYLE--ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVK 537 GM +L E L +R+V++ A+IS + + ++ Y Sbjct: 122 RGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQSPGRMYAPA-------- 173 Query: 538 WYAPECINYYKFSS---KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLE-KGERMGC 593 W APE + + +D+WSF VL+WE + + P+ + E+ + +G R Sbjct: 174 WVAPEALQKKPEDTNRRSADMWSFAVLLWELVTR-EVPFADLSNMEIGMKVALEGLRPTI 232 Query: 594 PAGCPREMYDLMNLCWTYDVENRPGFAAV 622 P G + LM +C D RP F + Sbjct: 233 PPGISPHVSKLMKICMNEDPAKRPKFDMI 261 >4M4Z-A nrPDB Length = 170 Score = 53.9 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 34/98 (34%), Positives = 52/98 (53%), Gaps = 6/98 (6%) Query: 168 WFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCLLHE-----GKVLHYRIDKD 221 W + +SRE++E+++L+ G FLIR ++ GSY+L + ++ HYRI Sbjct: 71 WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCL 130 Query: 222 KTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPC 259 G L I F +L LV+HYS AD + +L PC Sbjct: 131 DNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPC 168 Score = 50.8 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 32/97 (32%), Positives = 52/97 (53%), Gaps = 5/97 (5%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKA-----HHYTIERE 69 + + ++RE+AE+ L+ G G +L+R+S+ G ++LSV R A HY I Sbjct: 71 WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCL 130 Query: 70 LNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKP 106 NG I+ T S L ++S+ +D + CLLK+P Sbjct: 131 DNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEP 167 >6GVJ-A nrPDB Length = 429 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 62/266 (23%), Positives = 125/266 (46%), Gaps = 39/266 (14%) Query: 375 KELGSGNFGTVKKGYYQMKKV--VKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 K++GSG V + + K++ +K V ++ N+ D + ++E+ A N +QQ + I Sbjct: 150 KQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLD-SYRNEI-AYLNKLQQHSDK-I 206 Query: 433 VRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKD-------KNIIELVHQVSMGMKY 484 +R+ + ++ +VME + LN +L++ + + KN++E VH + Sbjct: 207 IRLYDYEITDQYIYMVMECGNID-LNSWLKKKKSIDPWERKSYWKNMLEAVHTI------ 259 Query: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADE-NYYKAQTHGKWPVKWYAPEC 543 + VH DL N L+V K+ DFG++ ++ D + K G V + PE Sbjct: 260 -HQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGT--VNYMPPEA 315 Query: 544 INYYKFSSKS-----------DVWSFGVLMWEAFSYGQKPYRGM--KGSEVTAMLEKGER 590 I S ++ DVWS G +++ +YG+ P++ + + S++ A+++ Sbjct: 316 IKDMSSSRENGKSKSKISPKSDVWSLGCILY-YMTYGKTPFQQIINQISKLHAIIDPNHE 374 Query: 591 MGCPAGCPREMYDLMNLCWTYDVENR 616 + P +++ D++ C D + R Sbjct: 375 IEFPDIPEKDLQDVLKCCLKRDPKQR 400 >2PLE-A nrPDB Length = 105 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 26/82 (31%), Positives = 47/82 (57%), Gaps = 3/82 (3%) Query: 163 HEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDK 222 HE W+H ++R ++E + L+ +G FL+R R+ SYA+ EGK+ H R+ ++ Sbjct: 6 HESKEWYHASLTRAQAEHM-LMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE- 63 Query: 223 TGKLSIPEGKKFDTLWQLVEHY 244 G+ + +FD+L L+ +Y Sbjct: 64 -GQTVMLGNSEFDSLVDLISYY 84 >5FQD-C nrPDB Length = 341 Score = 53.5 bits (127), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 71/283 (25%), Positives = 122/283 (43%), Gaps = 35/283 (12%) Query: 375 KELGSGNFGTVKKGYYQMKKVV--KTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 +++GSG+FG + Y + + VAVK+ +A P +LL E+ + + L Sbjct: 25 RKIGSGSFGDI----YLAINITNGEEVAVKLESQKARHP----QLLYESKLYKILQGGVG 76 Query: 433 VRMIGICEAESWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGMKYLEESNF 490 + I E V+ M LGP + L +R K ++ L Q+ ++Y+ NF Sbjct: 77 IPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNF 136 Query: 491 VHRDLAARNVLL-VTQHYAKIS--DFGLSKALRADENY----YKAQTHGKWPVKWYAPEC 543 +HRD+ N L+ + +H K+ DFGL+K R + Y+ + ++ + Sbjct: 137 IHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINA 196 Query: 544 INYYKFSSKSDVWSFG-VLMWEAFSYGQKPYRGMKGSEVTAMLEK--GERMGCPA----- 595 + S + D+ S G VLM+ F+ P++G+K + EK ++M P Sbjct: 197 HLGIEQSRRDDMESLGYVLMY--FNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCK 254 Query: 596 GCPREMYDLMNLCWTYDVENRPGFA------AVELRLRNYYYD 632 G P E +N C E P + + R N+ YD Sbjct: 255 GFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYD 297 >2AUG-A nrPDB Length = 126 Score = 53.5 bits (127), Expect = 3e-07, Method: Composition-based stats. Identities = 29/87 (33%), Positives = 51/87 (58%), Gaps = 5/87 (5%) Query: 163 HEKMPWFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHYRI--- 218 H PWFH KISR+E++++++ +G FL+R ++ N ++ L + H K+ H++I Sbjct: 23 HRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPV 82 Query: 219 DKDKTGKLSIPEG-KKFDTLWQLVEHY 244 + D ++ +G +F L QLVE Y Sbjct: 83 EDDGEMFHTLDDGHTRFTDLIQLVEFY 109 Score = 51.6 bits (122), Expect = 1e-06, Method: Composition-based stats. Identities = 23/67 (34%), Positives = 42/67 (62%), Gaps = 5/67 (7%) Query: 5 GMADSANHL-----PFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGR 59 G+ +H+ P+F I+R+EA+ ++Q G+ DG++L+R S++ F LS++HG+ Sbjct: 13 GLVPRGSHMIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQ 72 Query: 60 KAHHYTI 66 K H+ I Sbjct: 73 KIKHFQI 79 >2WTK-C nrPDB Length = 305 Score = 53.5 bits (127), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 60/267 (22%), Positives = 111/267 (41%), Gaps = 25/267 (9%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 LG G++G VK+ + V + K P + + E ++++L + +++++ Sbjct: 13 LGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLV 72 Query: 437 GIC---EAESWMLVMEMAELG--------PLNKYLQQNRHVKDKNIIELVHQVSMGMKYL 485 + E + +VME G P ++ H +I+ G++YL Sbjct: 73 DVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLID-------GLEYL 125 Query: 486 EESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 VH+D+ N+LL T KIS G+++AL +T P + PE N Sbjct: 126 HSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPA-FQPPEIAN 184 Query: 546 YYKFSS--KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYD 603 S K D+WS GV ++ + G P+ G ++ + KG P C + D Sbjct: 185 GLDTFSGFKVDIWSAGVTLYN-ITTGLYPFEGDNIYKLFENIGKGS-YAIPGDCGPPLSD 242 Query: 604 LMNLCWTYDVENRPGFAAVELRLRNYY 630 L+ Y+ R F+ ++R +++ Sbjct: 243 LLKGMLEYEPAKR--FSIRQIRQHSWF 267 >5AIR-A nrPDB Length = 430 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 74/281 (26%), Positives = 123/281 (43%), Gaps = 44/281 (15%) Query: 345 TEVYESPYADPEEIRPKEV-YLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKI 403 T V +P P+ RP+EV Y D K++ G+G+FG V YQ K+ + + Sbjct: 48 TTVVATPGQGPD--RPQEVSYTDTKVI-------GNGSFGVV----YQ-AKLCDSGELVA 93 Query: 404 LKNEANDPALKDELLAEANVMQQLDNPYIVRM----IGICEAESWMLVMEMAELGPLNKY 459 +K D K+ E +M++LD+ IVR+ E + + + + + P Y Sbjct: 94 IKKVLQDKRFKNR---ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVY 150 Query: 460 LQQNRHVKDKNIIELVH------QVSMGMKYLEESNFVHRDLAARNVLLVTQHYA-KISD 512 + + K + +++ Q+ + Y+ HRD+ +N+LL K+ D Sbjct: 151 RVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCD 210 Query: 513 FGLSKAL-RADENY-YKAQTHGKWPVKWYAPECI-NYYKFSSKSDVWSFGVLMWEAFSYG 569 FG +K L R + N Y + + APE I ++S DVWS G ++ E G Sbjct: 211 FGSAKQLVRGEPNVSYICSRY------YRAPELIFGATDYTSSIDVWSAGCVLAELL-LG 263 Query: 570 QKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWT 610 Q + G G V ++E + +G P RE MN +T Sbjct: 264 QPIFPGDSG--VDQLVEIIKVLGTPT---REQIREMNPNYT 299 >3OZ6-A nrPDB Length = 388 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 55/219 (25%), Positives = 97/219 (44%), Gaps = 35/219 (15%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLD-NPYIV 433 K+LG G +G V K ++ + VAVK + + + E ++ +L + IV Sbjct: 15 KKLGKGAYGIVWKSID--RRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSGHENIV 72 Query: 434 RMIGICEAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVH------QVSMGMKYLE 486 ++ + A++ V + + Y++ + H V NI+E VH Q+ +KYL Sbjct: 73 NLLNVLRADNDRDVYLVFD------YMETDLHAVIRANILEPVHKQYVVYQLIKVIKYLH 126 Query: 487 ESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL---------------RADENYYKAQ-- 529 +HRD+ N+LL + + K++DFGLS++ EN+ Q Sbjct: 127 SGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQPI 186 Query: 530 THGKWPVKWY-APEC-INYYKFSSKSDVWSFGVLMWEAF 566 +WY APE + K++ D+WS G ++ E Sbjct: 187 LTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEIL 225 >2ZMD-A nrPDB Length = 390 Score = 53.1 bits (126), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 60/265 (22%), Positives = 123/265 (46%), Gaps = 37/265 (13%) Query: 375 KELGSGNFGTVKKGYYQMKKV--VKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 K++GSG V + + K++ +K V ++ N+ D + ++E+ A N +QQ + I Sbjct: 62 KQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLD-SYRNEI-AYLNKLQQHSDK-I 118 Query: 433 VRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKD-------KNIIELVHQVSMGMKY 484 +R+ + ++ +VME + LN +L++ + + KN++E VH + Sbjct: 119 IRLYDYEITDQYIYMVMECGNID-LNSWLKKKKSIDPWERKSYWKNMLEAVHTI------ 171 Query: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 + VH DL N L+V K+ DFG++ ++ D + V + PE I Sbjct: 172 -HQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQ-VGAVNYMPPEAI 228 Query: 545 NYYKFSSKS-----------DVWSFGVLMWEAFSYGQKPYRGM--KGSEVTAMLEKGERM 591 S ++ DVWS G +++ +YG+ P++ + + S++ A+++ + Sbjct: 229 KDMSSSRENGKSKSKISPKSDVWSLGCILY-YMTYGKTPFQQIINQISKLHAIIDPNHEI 287 Query: 592 GCPAGCPREMYDLMNLCWTYDVENR 616 P +++ D++ C D + R Sbjct: 288 EFPDIPEKDLQDVLKCCLKRDPKQR 312 >5J5T-A nrPDB Length = 370 Score = 53.1 bits (126), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 48/195 (24%), Positives = 83/195 (42%), Gaps = 13/195 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNE-ANDPALKDELLAEANVMQQLDNPYIV 433 + +GSG +G V K + + A+K++K E D A+ + E +M+ +P IV Sbjct: 10 QRIGSGTYGDVYKA--RNVNTGELAAIKVIKLEPGEDFAVVQQ---EIIMMKDCKHPNIV 64 Query: 434 RMIG-ICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 G + + ME G L + + I + + G+ YL +H Sbjct: 65 AYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMH 124 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK---F 549 RD+ N+LL + K++DFG+S + A KA + W APE + + Sbjct: 125 RDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPY---WMAPEVAAVERKGGY 181 Query: 550 SSKSDVWSFGVLMWE 564 + D+W+ G+ E Sbjct: 182 NQLCDLWAVGITAIE 196 >6CQF-A nrPDB Length = 297 Score = 53.1 bits (126), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 49/200 (24%), Positives = 84/200 (42%), Gaps = 23/200 (11%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEAND--PALKDELLA-----EANVMQQL 427 + LG G +G V K ++ VA+K++K E +D L+ E+L AN++ Sbjct: 22 QRLGGGTYGEVFKARDKVSG--DLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYH 79 Query: 428 DNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 487 + ++ + IC ME G L Q + + I + +V G+ YL Sbjct: 80 GSYLWLQKLWIC--------MEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHS 131 Query: 488 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY 547 +HRD+ N+L+ +++DFG+S + A A + W APE Sbjct: 132 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPY---WMAPEVAAVA 188 Query: 548 ---KFSSKSDVWSFGVLMWE 564 ++ D+WS G+ E Sbjct: 189 LKGGYNELCDIWSLGITAIE 208 >5Y86-A nrPDB Length = 588 Score = 53.1 bits (126), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 55/227 (24%), Positives = 108/227 (47%), Gaps = 31/227 (13%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K +G G+FG V + Y K+ + VA+K+++NE E + +++ D + Sbjct: 213 KIIGKGSFGQVARVYDH--KLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMN 270 Query: 435 MIGICEAESW---------MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYL 485 +I + E+ ++ +L +++ EL NK+ + + + + + + L Sbjct: 271 VIHMLESFTFRNHVCMAFELLSIDLYELIKKNKF----QGFSVQLVRKFAQSILQSLDAL 326 Query: 486 EESNFVHRDLAARNVLLVTQHYA----KISDFGLSKALRADENYYKAQTHGKWPVKWY-A 540 ++ +H DL N+LL +H+ K+ DFG S + Y Q+ ++Y A Sbjct: 327 HKNKIIHCDLKPENILL--KHHGRSSTKVIDFG-SSCFEYQKLYTYIQS------RFYRA 377 Query: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGM-KGSEVTAMLE 586 PE I ++S+ D+WSFG ++ E + GQ + G +G ++ M+E Sbjct: 378 PEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMME 423 >3NYO-A nrPDB Length = 576 Score = 52.8 bits (125), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 59/258 (22%), Positives = 109/258 (42%), Gaps = 40/258 (15%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDEL-LAEANVMQQLDNPYIVRM 435 LG G FG V Q++ K A K L+ + + + L E +++++++ ++V + Sbjct: 192 LGKGGFGEV--CACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 Query: 436 IGICEA-ESWMLVMEMAELGPL--NKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 E ++ LV+ + G L + Y + + ++ G++ L V+ Sbjct: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSK 552 RDL N+LL + +ISD GL A+ E G V + APE + +++ Sbjct: 310 RDLKPENILLDDHGHIRISDLGL--AVHVPEGQTIKGRVGT--VGYMAPEVVKNERYTFS 365 Query: 553 SDVWSFGVLMWEAFSYGQKPY----RGMKGSEVTAMLEK--------------------- 587 D W+ G L++E + GQ P+ + +K EV ++++ Sbjct: 366 PDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLL 424 Query: 588 ----GERMGCPAGCPREM 601 ER+GC G RE+ Sbjct: 425 CKDPAERLGCRGGSAREV 442 >3HMP-A nrPDB Length = 342 Score = 52.8 bits (125), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 60/265 (22%), Positives = 123/265 (46%), Gaps = 37/265 (13%) Query: 375 KELGSGNFGTVKKGYYQMKKV--VKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 K++GSG V + + K++ +K V ++ N+ D + ++E+ A N +QQ + I Sbjct: 62 KQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLD-SYRNEI-AYLNKLQQHSDK-I 118 Query: 433 VRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKD-------KNIIELVHQVSMGMKY 484 +R+ + ++ +VME + LN +L++ + + KN++E VH + Sbjct: 119 IRLYDYEITDQYIYMVMECGNID-LNSWLKKKKSIDPWERKSYWKNMLEAVHTI------ 171 Query: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 + VH DL N L+V K+ DFG++ ++ D + V + PE I Sbjct: 172 -HQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVG-TVNYMPPEAI 228 Query: 545 NYYKFSSKS-----------DVWSFGVLMWEAFSYGQKPYRGM--KGSEVTAMLEKGERM 591 S ++ DVWS G +++ +YG+ P++ + + S++ A+++ + Sbjct: 229 KDMSSSRENGKSKSKISPKSDVWSLGCILY-YMTYGKTPFQQIINQISKLHAIIDPNHEI 287 Query: 592 GCPAGCPREMYDLMNLCWTYDVENR 616 P +++ D++ C D + R Sbjct: 288 EFPDIPEKDLQDVLKCCLKRDPKQR 312 >6HV0-A nrPDB Length = 416 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 53/208 (25%), Positives = 92/208 (44%), Gaps = 20/208 (9%) Query: 377 LGSGNFGT-VKKGYYQMKKVVKTVAVKILKNEANDPALKD-ELLAEANVMQQLDNPYIVR 434 LG G GT V +G + + V AVK + E A ++ +LL E++ ++P ++R Sbjct: 16 LGHGAEGTIVYRGMFDNRDV----AVKRILPECFSFADREVQLLRESD-----EHPNVIR 66 Query: 435 MIGICEAESWMLVMEMAELGPLNKYLQQNRHVK-DKNIIELVHQVSMGMKYLEESNFVHR 493 + + + L +Y++Q I L+ Q + G+ +L N VHR Sbjct: 67 YFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHR 126 Query: 494 DLAARNVLLVTQHY-----AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 DL N+L+ + A ISDFGL K L + + ++ W APE ++ Sbjct: 127 DLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDC 186 Query: 549 FSSKS---DVWSFGVLMWEAFSYGQKPY 573 + + D++S G + + S G P+ Sbjct: 187 KENPTYTVDIFSAGCVFYYVISEGSHPF 214 >5L2Q-C nrPDB Length = 320 Score = 52.4 bits (124), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 33/125 (26%), Positives = 67/125 (53%), Gaps = 6/125 (4%) Query: 451 AELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQ-HYAK 509 A+L L Y+ + + + ++ + + + V ++ L + N VHRDL N++L + H Sbjct: 135 ADLINLQHYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRIT 194 Query: 510 ISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSK-SDVWSFGVLMWEAFSY 568 I++F L K L ++ + K Q + + +P+ ++ + K SD+W+ GV+++ Y Sbjct: 195 ITNFCLGKHLVSEGDLLKDQ---RGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTML-Y 250 Query: 569 GQKPY 573 GQ P+ Sbjct: 251 GQFPF 255 >3SV0-A nrPDB Length = 483 Score = 52.4 bits (124), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 65/276 (23%), Positives = 125/276 (45%), Gaps = 31/276 (11%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPY--- 431 +++GSG+FG + G + + VA+K+ + P +LL E+ + + L Sbjct: 13 RKIGSGSFGEIYLG--TNIQTNEEVAIKLENVKTKHP----QLLYESKIYRILQGGTGIP 66 Query: 432 IVRMIGICEAESWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGMKYLEESN 489 VR G+ E + +LVM++ LGP + L +R + K ++ L Q+ ++++ + Sbjct: 67 NVRWFGV-EGDYNVLVMDL--LGPSLEDLFNFCSRKLSLKTVLMLADQMINRVEFVHSKS 123 Query: 490 FVHRDLAARNVLLVTQHYAK---ISDFGLSKALRADENY----YKAQTHGKWPVKWYAPE 542 F+HRD+ N L+ A I DFGL+K R + Y+ + ++ + Sbjct: 124 FLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTARYASVN 183 Query: 543 CINYYKFSSKSDVWSFG-VLMWEAFSYGQKPYRGMKGS----EVTAMLEKGERMGCPAGC 597 + S + D+ S G VLM+ F G P++G+K + + EK A C Sbjct: 184 THLGIEQSRRDDLESLGYVLMY--FLRGSLPWQGLKAGTKKQKYEKISEKKVATSIEALC 241 Query: 598 ---PREMYDLMNLCWTYDVENRPGFAAVELRLRNYY 630 P E + C + +++P ++ ++ R+ + Sbjct: 242 RGYPTEFASYFHYCRSLRFDDKPDYSYLKRLFRDLF 277 >3Q4U-A nrPDB Length = 301 Score = 52.0 bits (123), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 51/213 (23%), Positives = 90/213 (42%), Gaps = 36/213 (16%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE------LLAEANVMQQLDNP 430 +G G +G V +G +Q + V AVKI + ++ +L N++ + + Sbjct: 16 VGKGRYGEVWRGSWQGENV----AVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASD 71 Query: 431 YIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 R + W L+ E+G L YLQ + + + +V ++ G+ +L F Sbjct: 72 MTSRH---SSTQLW-LITHYHEMGSLYDYLQLTT-LDTVSCLRIVLSIASGLAHLHIEIF 126 Query: 491 --------VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-AP 541 HRDL ++N+L+ I+D GL+ N + + K Y AP Sbjct: 127 GTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAP 186 Query: 542 E---------CINYYKFSSKSDVWSFGVLMWEA 565 E C + YK + D+W+FG+++WE Sbjct: 187 EVLDETIQVDCFDSYK---RVDIWAFGLVLWEV 216 >5WAX-A nrPDB Length = 310 Score = 52.0 bits (123), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 54/195 (27%), Positives = 87/195 (44%), Gaps = 17/195 (8%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVK-ILKNEANDPALKDELLAEANVMQQLDNPYIV 433 +++GSGNFG + + + + VAVK I + E D ++ E++ + L +P I+ Sbjct: 17 RDIGSGNFGVAR--LMRNRADGQLVAVKYIERGEKIDENVQREIINH----RSLRHPNII 70 Query: 434 RMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 R + + + +VME A G L + + + Q+ G+ Y H Sbjct: 71 RFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHSMQVCH 130 Query: 493 RDLAARNVLL--VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECINYYKF 549 RDL N LL T KI DFG SK+ + +Q Y APE + ++ Sbjct: 131 RDLKLENTLLDGSTAPRLKICDFGYSKS-----SVLHSQPKSTVGTPAYIAPEVLLKKEY 185 Query: 550 SSK-SDVWSFGVLMW 563 K +DVWS GV ++ Sbjct: 186 DGKVADVWSCGVTLY 200 >4U41-A nrPDB Length = 332 Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 36/126 (28%), Positives = 58/126 (46%), Gaps = 10/126 (7%) Query: 446 LVMEMAELGPLNKYLQQNR--HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV 503 LVME G + ++ + +K+ I + ++ G+ +L + +HRD+ +NVLL Sbjct: 104 LVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLT 163 Query: 504 TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY-----YKFSSKSDVWSF 558 K+ DFG+S L D + T P W APE I + +SD+WS Sbjct: 164 ENAEVKLVDFGVSAQL--DRTVGRRNTFIGTPY-WMAPEVIACDENPDATYDYRSDLWSC 220 Query: 559 GVLMWE 564 G+ E Sbjct: 221 GITAIE 226 >2EKX-A nrPDB Length = 110 Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 29/98 (29%), Positives = 49/98 (50%), Gaps = 7/98 (7%) Query: 168 WFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHE------GKVLHYRIDKD 221 WF G ISR +SEQ++ K G F++R G Y + L + G V HY + + Sbjct: 13 WFAGNISRSQSEQLLRQKGK-EGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTN 71 Query: 222 KTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPC 259 KL + E FD++ +L+ ++ + + G++ L P Sbjct: 72 AENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPV 109 Score = 37.7 bits (86), Expect = 0.017, Method: Compositional matrix adjust. Identities = 31/111 (27%), Positives = 51/111 (45%), Gaps = 12/111 (10%) Query: 2 ASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSV----AH 57 SSG+ D +F GNI+R ++E L Q G +G +++R S +G + +S+ + Sbjct: 4 GSSGLDD----YDWFAGNISRSQSEQLLRQKG-KEGAFMVRNSSQ-VGMYTVSLFSKAVN 57 Query: 58 GRKA--HHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKP 106 +K HY + +A S L HYH S G++ L+ P Sbjct: 58 DKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHP 108 >5AP3-A nrPDB Length = 313 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 60/265 (22%), Positives = 123/265 (46%), Gaps = 37/265 (13%) Query: 375 KELGSGNFGTVKKGYYQMKKV--VKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 K++GSG V + + K++ +K V ++ N+ D + ++E+ A N +QQ + I Sbjct: 34 KQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLD-SYRNEI-AYLNKLQQHSDK-I 90 Query: 433 VRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKD-------KNIIELVHQVSMGMKY 484 +R+ + ++ +VME + LN +L++ + + KN++E VH + Sbjct: 91 IRLYDYEITDQYIYMVMECGNID-LNGWLKKKKSIDPWERKSYWKNMLEAVHTI------ 143 Query: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 + VH DL N L+V K+ DFG++ ++ D + V + PE I Sbjct: 144 -HQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVG-TVNYMPPEAI 200 Query: 545 NYYKFSSKS-----------DVWSFGVLMWEAFSYGQKPYRGM--KGSEVTAMLEKGERM 591 S ++ DVWS G +++ +YG+ P++ + + S++ A+++ + Sbjct: 201 KDMSSSRENGKSKSKISPKSDVWSLGCILY-YMTYGKTPFQQIINQISKLHAIIDPNHEI 259 Query: 592 GCPAGCPREMYDLMNLCWTYDVENR 616 P +++ D++ C D + R Sbjct: 260 EFPDIPEKDLQDVLKCCLKRDPKQR 284 >6E9W-A nrPDB Length = 443 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 53/210 (25%), Positives = 93/210 (44%), Gaps = 22/210 (10%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKN----EANDPALKDELLAEANVMQQLDNP 430 K +G G FG V+ + K K A+K+L + +D A E ++M ++P Sbjct: 108 KVIGRGAFGEVQ--LVRHKSTRKVYAMKLLSKFEMIKRSDSAF---FWEERDIMAFANSP 162 Query: 431 YIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 ++V++ + + ++ +VME G L L N V +K +V + + + Sbjct: 163 WVVQLFYAFQDDRYLYMVMEYMPGGDLVN-LMSNYDVPEKWARFYTAEVVLALDAIHSMG 221 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN---- 545 F+HRD+ N+LL + K++DFG + E + T P + +PE + Sbjct: 222 FIHRDVKPDNMLLDKSGHLKLADFGTCMKMNK-EGMVRCDTAVGTP-DYISPEVLKSQGG 279 Query: 546 --YYKFSSKSDVWSFGVLMWEAFSYGQKPY 573 YY + D WS GV ++E G P+ Sbjct: 280 DGYY--GRECDWWSVGVFLYEML-VGDTPF 306 >4XHH-A nrPDB Length = 403 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 65/264 (24%), Positives = 115/264 (43%), Gaps = 29/264 (10%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +++GSG+FG + G + + VA+++ + P L E + + P+I R Sbjct: 13 RKIGSGSFGDIYHGTNLISG--EEVAIRLESIRSRHPQLDYESRVYKYLSGGVGIPFI-R 69 Query: 435 MIGICEAESWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 G E E +V+++ LGP + L +R K +I L Q+ ++Y+ +F+H Sbjct: 70 WFGR-EGEYNAMVIDL--LGPSLEDLFNYCHRKFSFKTVIMLALQMICRVQYIHGRSFIH 126 Query: 493 RDLAARNVLL------VTQHYAKISDFGLSKALRADENY----YKAQTHGKWPVKWYAPE 542 RD+ N L+ T H + DFGLSK R + Y+ ++ + Sbjct: 127 RDIKPDNFLMGVGRRGSTVH---VIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVN 183 Query: 543 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGS----EVTAMLEKGERMGCP---A 595 + S + D+ S G ++ F G P++G+K + + +LEK + A Sbjct: 184 THLGIEQSRRDDLESLGYMLI-YFCKGSLPWQGLKATTKKQKYDRILEKKLCISVETLCA 242 Query: 596 GCPREMYDLMNLCWTYDVENRPGF 619 G P E + MN C + RP + Sbjct: 243 GLPLEFSEYMNYCRNLKFDERPDY 266 >2QLU-A nrPDB Length = 314 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 42/145 (28%), Positives = 70/145 (48%), Gaps = 21/145 (14%) Query: 440 EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES----------- 488 E E W L+ + G L YL+ N + + + +S G+ YL E Sbjct: 85 EVELW-LITAFHDKGSLTDYLKGNI-ITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKP 142 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APE----C 543 + HRD ++NVLL + A ++DFGL A+R + THG+ + Y APE Sbjct: 143 SIAHRDFKSKNVLLKSDLTAVLADFGL--AVRFEPGKPPGDTHGQVGTRRYMAPEVLEGA 200 Query: 544 INYYKFSS-KSDVWSFGVLMWEAFS 567 IN+ + + + D+++ G+++WE S Sbjct: 201 INFQRDAFLRIDMYAMGLVLWELVS 225 >3ZUT-A nrPDB Length = 362 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 56/195 (28%), Positives = 86/195 (44%), Gaps = 17/195 (8%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVK-ILKNEANDPALKDELLAEANVMQQLDNPYIV 433 K++GSGNFG + + K+ + VAVK I + E D +K E++ + L +P IV Sbjct: 25 KDIGSGNFGVAR--LMRDKQSNELVAVKYIERGEKIDENVKREIINH----RSLRHPNIV 78 Query: 434 RMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 R + + + +VME A G L + + + Q+ G+ Y H Sbjct: 79 RFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCH 138 Query: 493 RDLAARNVLL--VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECINYYKF 549 RDL N LL KI FG SK+ + +Q Y APE + ++ Sbjct: 139 RDLKLENTLLDGSPAPRLKICAFGYSKS-----SVLHSQPKSTVGTPAYIAPEVLLKKEY 193 Query: 550 SSK-SDVWSFGVLMW 563 K +DVWS GV ++ Sbjct: 194 DGKVADVWSCGVTLY 208 >3BHH-A nrPDB Length = 295 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 46/200 (23%), Positives = 89/200 (44%), Gaps = 23/200 (11%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTV-----AVKILKNEANDPALKDELLAEANVMQQLDN 429 +++G G F V++ VK A KI+ + +L EA + + L + Sbjct: 10 EDIGKGAFSVVRR-------CVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKH 62 Query: 430 PYIVRM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 IVR+ I E LV ++ G L + + + + + + Q+ + + + Sbjct: 63 SNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQM 122 Query: 489 NFVHRDLAARNVLLVTQ---HYAKISDFGLSKALRADENYY--KAQTHGKWPVKWYAPEC 543 VHRDL N+LL ++ K++DFGL+ ++ D+ + A T G + +PE Sbjct: 123 GVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPG-----YLSPEV 177 Query: 544 INYYKFSSKSDVWSFGVLMW 563 + + D+W+ GV+++ Sbjct: 178 LRKEAYGKPVDIWACGVILY 197 >4X7Q-B nrPDB Length = 312 Score = 50.1 bits (118), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 53/209 (25%), Positives = 94/209 (44%), Gaps = 20/209 (9%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNE--------ANDPALKDELLAEANVMQQLD 428 LG G FGTV G+ ++ VA+K++ ++ E+ V Sbjct: 39 LGKGGFGTVFAGHRLTDRL--QVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGG 96 Query: 429 NPYIVRMIGICEA-ESWMLVMEMA-ELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE 486 +P ++R++ E E +MLV+E L Y+ + + + QV +++ Sbjct: 97 HPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCH 156 Query: 487 ESNFVHRDLAARNVLL-VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 VHRD+ N+L+ + + AK+ DFG S AL DE Y T + PE I+ Sbjct: 157 SRGVVHRDIKDENILIDLRRGCAKLIDFG-SGALLHDEPY----TDFDGTRVYSPPEWIS 211 Query: 546 YYKFSS-KSDVWSFGVLMWEAFSYGQKPY 573 +++ + + VWS G+L+++ G P+ Sbjct: 212 RHQYHALPATVWSLGILLYDMVC-GDIPF 239 >3QD2-B nrPDB Length = 332 Score = 50.1 bits (118), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 28/97 (28%), Positives = 47/97 (48%), Gaps = 9/97 (9%) Query: 477 QVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQT------ 530 Q++ +++L +HRDL N+ K+ DFGL A+ DE T Sbjct: 172 QIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYA 231 Query: 531 --HGKWPVKWY-APECINYYKFSSKSDVWSFGVLMWE 564 G+ K Y +PE I+ +S K D++S G++++E Sbjct: 232 THTGQVGTKLYMSPEQIHGNNYSHKVDIFSLGLILFE 268 >3SOA-A nrPDB Length = 444 Score = 50.1 bits (118), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 43/195 (22%), Positives = 88/195 (45%), Gaps = 13/195 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +ELG G F V++ + + A I+ + +L EA + + L +P IVR Sbjct: 17 EELGKGAFSVVRRCVKVLAG--QEYAAMIINTKKLSARDHQKLEREARICRLLKHPNIVR 74 Query: 435 M-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + I E L+ ++ G L + + + + + + Q+ + + + VHR Sbjct: 75 LHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHR 134 Query: 494 DLAARNVLLVTQ---HYAKISDFGLSKALRADENYY--KAQTHGKWPVKWYAPECINYYK 548 +L N+LL ++ K++DFGL+ + ++ + A T G + +PE + Sbjct: 135 NLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPG-----YLSPEVLRKDP 189 Query: 549 FSSKSDVWSFGVLMW 563 + D+W+ GV+++ Sbjct: 190 YGKPVDLWACGVILY 204 >3TKU-A nrPDB Length = 433 Score = 50.1 bits (118), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 58/230 (25%), Positives = 102/230 (44%), Gaps = 14/230 (6%) Query: 352 YADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEAND 410 +A P KE+ L R+ + K +G G FG V +MK + A+KIL K E Sbjct: 74 WAKPFTQLVKEMQLHREDFEII-KVIGRGAFGEV--AVVKMKNTERIYAMKILNKWEMLK 130 Query: 411 PALKDELLAEANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDK 469 A E +V+ D +I + + E+ + LVM+ G L L + + Sbjct: 131 RAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPE 190 Query: 470 NIIEL-VHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKA 528 ++ + ++ + + + + ++VHRD+ NVLL + +++DFG + D + Sbjct: 191 DMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSS 250 Query: 529 QTHGKWPVKWYAPECINYY-----KFSSKSDVWSFGVLMWEAFSYGQKPY 573 G + +PE + K+ + D WS GV M+E YG+ P+ Sbjct: 251 VAVGT--PDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEML-YGETPF 297 >1KA6-A nrPDB Length = 128 Score = 49.7 bits (117), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 33/118 (27%), Positives = 57/118 (48%), Gaps = 11/118 (9%) Query: 169 FHGKISREESEQIVLIGSKTNGKFLIRARDN-NGSYALCLLHEGKVLHYRIDKDKTGKLS 227 +HGKISRE E++ L+ + +G +L+R ++ G Y LC+L+ G + YR+ + +TG S Sbjct: 7 YHGKISRETGEKL-LLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWS 65 Query: 228 IPEG-----KKFDTLWQLVEHYSYKADGLLRVLTVPCQKI----GTQGNVNFGGRPQL 276 + F + L+ + G++ L P +K TQG P + Sbjct: 66 AETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEKKSSARSTQGTTGIREDPDV 123 Score = 35.0 bits (79), Expect = 0.088, Method: Compositional matrix adjust. Identities = 19/65 (29%), Positives = 34/65 (52%), Gaps = 1/65 (1%) Query: 11 NHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIEREL 70 + + + G I+RE E L+ G+ DG YLLR S + G + L V + + Y + + Sbjct: 2 DAVAVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTE 60 Query: 71 NGTYA 75 G+++ Sbjct: 61 TGSWS 65 >3M42-A nrPDB Length = 299 Score = 49.7 bits (117), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 40/173 (23%), Positives = 76/173 (43%), Gaps = 36/173 (20%) Query: 430 PYIVRMIGICE-----AESWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGM 482 P+IVR++ + E + ++VME + G L +Q ++ ++ E++ + + Sbjct: 71 PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAI 130 Query: 483 KYLEESNFVHRDLAARNVLLVTQH---YAKISDFGLSKALRADENYYKAQTHGKWPVKWY 539 +YL N HRD+ N+L ++ K++DFG +K +T G+ Sbjct: 131 QYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK-----------ETTGE------ 173 Query: 540 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMG 592 K+ D+WS GV+M+ G P+ G ++ ++ RMG Sbjct: 174 --------KYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMG 217 >1M27-A nrPDB Length = 104 Score = 49.3 bits (116), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 29/99 (29%), Positives = 52/99 (52%), Gaps = 7/99 (7%) Query: 169 FHGKISREESEQIVLIGSKTNGKFLIRARDN-NGSYALCLLHEGKVLHYRIDKDKTGKLS 227 +HGKISRE E++ L+ + +G +L+R ++ G Y LC+L+ G + YR+ + +TG S Sbjct: 7 YHGKISRETGEKL-LLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWS 65 Query: 228 IPEG-----KKFDTLWQLVEHYSYKADGLLRVLTVPCQK 261 + F + L+ + G++ L P +K Sbjct: 66 AETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEK 104 Score = 34.7 bits (78), Expect = 0.15, Method: Compositional matrix adjust. Identities = 19/65 (29%), Positives = 34/65 (52%), Gaps = 1/65 (1%) Query: 11 NHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIEREL 70 + + + G I+RE E L+ G+ DG YLLR S + G + L V + + Y + + Sbjct: 2 DAVAVYHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTE 60 Query: 71 NGTYA 75 G+++ Sbjct: 61 TGSWS 65 >3TAC-A nrPDB Length = 361 Score = 49.3 bits (116), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 49/210 (23%), Positives = 93/210 (44%), Gaps = 13/210 (6%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNE--ANDPALKDE-LLAEANVMQQLDNPYIV 433 +G G F V++ ++ + AVKI+ + P L E L EA++ L +P+IV Sbjct: 34 IGKGPFSVVRRCIN--RETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIV 91 Query: 434 RMIGICEAESWM-LVMEMAELGPLNKYLQQNRHV----KDKNIIELVHQVSMGMKYLEES 488 ++ ++ + +V E + L + + + + Q+ ++Y ++ Sbjct: 92 ELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDN 151 Query: 489 NFVHRDLAARNVLLVT-QHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY 547 N +HRD+ VLL + ++ A + G A++ E+ A P + APE + Sbjct: 152 NIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTP-HFMAPEVVKRE 210 Query: 548 KFSSKSDVWSFGVLMWEAFSYGQKPYRGMK 577 + DVW GV+++ S G P+ G K Sbjct: 211 PYGKPVDVWGCGVILFILLS-GCLPFYGTK 239 >3SOC-A nrPDB Length = 322 Score = 49.3 bits (116), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 40/138 (28%), Positives = 67/138 (48%), Gaps = 19/138 (13%) Query: 446 LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES----------NFVHRDL 495 L+ E G L+ +L+ N V + + ++ G+ YL E HRD+ Sbjct: 99 LITAFHEKGSLSDFLKANV-VSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDI 157 Query: 496 AARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APE----CINYYKFS 550 ++NVLL A I+DFGL AL+ + THG+ + Y APE IN+ + + Sbjct: 158 KSKNVLLKNNLTACIADFGL--ALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDA 215 Query: 551 S-KSDVWSFGVLMWEAFS 567 + D+++ G+++WE S Sbjct: 216 FLRIDMYAMGLVLWELAS 233 >3MY0-A nrPDB Length = 305 Score = 49.3 bits (116), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 51/212 (24%), Positives = 90/212 (42%), Gaps = 36/212 (16%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE------LLAEANVMQQLDNP 430 +G G +G V +G + + +VAVKI + ++ LL N++ + + Sbjct: 16 VGKGRYGEVWRGLWHGE----SVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASD 71 Query: 431 YIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 R + W L+ E G L +LQ+ + ++ + L + G+ +L F Sbjct: 72 MTSRN---SSTQLW-LITHYHEHGSLYDFLQR-QTLEPHLALRLAVSAACGLAHLHVEIF 126 Query: 491 --------VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-AP 541 HRD +RNVL+ + I+D GL+ +Y + + K Y AP Sbjct: 127 GTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAP 186 Query: 542 E---------CINYYKFSSKSDVWSFGVLMWE 564 E C YK++ D+W+FG+++WE Sbjct: 187 EVLDEQIRTDCFESYKWT---DIWAFGLVLWE 215 >5ZTN-A nrPDB Length = 429 Score = 48.9 bits (115), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 50/205 (24%), Positives = 90/205 (43%), Gaps = 25/205 (12%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K +G G+FG V K Y KV + VA+K+++NE E + +++ D + Sbjct: 103 KVIGKGSFGQVVKAYDH--KVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMN 160 Query: 435 MIGICEAESW---------MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYL 485 +I + E ++ +L M + EL NK+ + + + H + + L Sbjct: 161 VIHMLENFTFRNHICMTFELLSMNLYELIKKNKF----QGFSLPLVRKFAHSILQCLDAL 216 Query: 486 EESNFVHRDLAARNVLLVTQHYA--KISDFGLSKALRADENYYKAQTHGKWPVKWY-APE 542 ++ +H DL N+LL Q + K+ DFG S Y + + ++Y APE Sbjct: 217 HKNRIIHCDLKPENILLKQQGRSGIKVIDFGSS-------CYEHQRVYTYIQSRFYRAPE 269 Query: 543 CINYYKFSSKSDVWSFGVLMWEAFS 567 I ++ D+WS G ++ E + Sbjct: 270 VILGARYGMPIDMWSLGCILAELLT 294 >1GRI-A nrPDB Length = 217 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 29/83 (34%), Positives = 45/83 (54%), Gaps = 2/83 (2%) Query: 14 PFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGT 73 P+FFG I R +AE+ L + DG +L+R+S + G F+LSV G H+ + R+ G Sbjct: 59 PWFFGKIPRAKAEEMLSKQ-RHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGK 117 Query: 74 YAIAGGRTHASPADLCHYHSQES 96 Y + + + S +L YH S Sbjct: 118 YFLWVVKFN-SLNELVDYHRSTS 139 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 26/79 (32%), Positives = 48/79 (60%), Gaps = 3/79 (3%) Query: 167 PWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDKTGK 225 PWF GKI R ++E++ L + +G FLIR ++ G ++L + V H+++ +D GK Sbjct: 59 PWFFGKIPRAKAEEM-LSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGK 117 Query: 226 LSIPEGKKFDTLWQLVEHY 244 + KF++L +LV+++ Sbjct: 118 YFL-WVVKFNSLNELVDYH 135 >4AW2-A nrPDB Length = 437 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 57/231 (24%), Positives = 102/231 (44%), Gaps = 16/231 (6%) Query: 352 YADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEAND 410 +A P + K++ L R+ + K +G G FG V ++K K A+KIL K E Sbjct: 58 WAKPFTSKVKQMRLHREDFEIL-KVIGRGAFGEV--AVVKLKNADKVFAMKILNKWEMLK 114 Query: 411 PALKDELLAEANVMQQLDNPYIVRM-IGICEAESWMLVMEMAELGPLNKYLQ--QNRHVK 467 A E +V+ D+ +I + + + LVM+ G L L ++R + Sbjct: 115 RAETACFREERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPE 174 Query: 468 DKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYK 527 + L V + + + + ++VHRD+ N+L+ + +++DFG L D Sbjct: 175 EMARFYLAEMV-IAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQS 233 Query: 528 AQTHGKWPVKWYAPECINYY-----KFSSKSDVWSFGVLMWEAFSYGQKPY 573 + G + +PE + ++ + D WS GV M+E YG+ P+ Sbjct: 234 SVAVGT--PDYISPEILQAMEGGKGRYGPECDWWSLGVCMYEML-YGETPF 281 >5TUR-A nrPDB Length = 404 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 51/209 (24%), Positives = 100/209 (47%), Gaps = 22/209 (10%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDEL------LAEANVMQQLDNP 430 LGSG FG+V G +V + V I E + + EL E +++++ + Sbjct: 135 LGSGGFGSVYSGI----RVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG 190 Query: 431 Y--IVRMIGICE-AESWMLVMEMAE-LGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE 486 + ++R++ E +S++L++E E + L ++ + ++++ QV +++ Sbjct: 191 FSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH 250 Query: 487 ESNFVHRDLAARNVLL-VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 +HRD+ N+L+ + + K+ DFG S AL D Y T + PE I Sbjct: 251 NCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVY----TDFDGTRVYSPPEWIR 305 Query: 546 YYKFSSKS-DVWSFGVLMWEAFSYGQKPY 573 Y+++ +S VWS G+L+++ G P+ Sbjct: 306 YHRYHGRSAAVWSLGILLYDMVC-GDIPF 333 >2HDV-A nrPDB Length = 111 Score = 48.1 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 29/100 (29%), Positives = 53/100 (53%), Gaps = 11/100 (11%) Query: 167 PWFHGKISREESEQIVLI-GSKTNGKFLIRARDN-NGSYALCLLHEGKVLHYRIDKDKTG 224 PWFHG +SR ++ Q+VL G+ ++G FL+R + G L +GK H R+ + G Sbjct: 10 PWFHGMLSRLKAAQLVLEGGTGSHGVFLVRQSETRRGECVLTFNFQGKAKHLRLSLNAAG 69 Query: 225 KLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGT 264 + + + F +++ ++EH+ RV +P + G+ Sbjct: 70 QCRV-QHLHFQSIFDMLEHF--------RVHPIPLESGGS 100 Score = 32.7 bits (73), Expect = 0.47, Method: Composition-based stats. Identities = 18/51 (35%), Positives = 29/51 (56%), Gaps = 1/51 (1%) Query: 14 PFFFGNITREEAEDYLVQGGM-SDGLYLLRQSRNYLGGFALSVAHGRKAHH 63 P+F G ++R +A +++GG S G++L+RQS G L+ KA H Sbjct: 10 PWFHGMLSRLKAAQLVLEGGTGSHGVFLVRQSETRRGECVLTFNFQGKAKH 60 >1PY5-A nrPDB Length = 326 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 57/216 (26%), Positives = 100/216 (46%), Gaps = 40/216 (18%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 + +G G FG V +G ++ ++V AVKI + ++ + + VM + +N Sbjct: 35 ESIGKGRFGEVWRGKWRGEEV----AVKIFSSREERSWFREAEIYQ-TVMLRHEN----- 84 Query: 435 MIGICEAE-----SWM---LVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYL 485 ++G A+ +W LV + E G L YL NR+ V + +I+L + G+ +L Sbjct: 85 ILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYL--NRYTVTVEGMIKLALSTASGLAHL 142 Query: 486 E--------ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRAD---ENYYKAQTHGKW 534 + HRDL ++N+L+ I+D GL A+R D + A H Sbjct: 143 HMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGL--AVRHDSATDTIDIAPNHRVG 200 Query: 535 PVKWYAPEC----INYYKFSS--KSDVWSFGVLMWE 564 ++ APE IN F S ++D+++ G++ WE Sbjct: 201 TKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWE 236 >5VDK-A nrPDB Length = 297 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 57/277 (20%), Positives = 113/277 (40%), Gaps = 35/277 (12%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTV--AVKILKNEANDPALKDELLAEANVMQQLDN 429 LE +++G G FGTV K ++ V + ++K +N+ + E+ A A + Sbjct: 18 LEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHH--- 74 Query: 430 PYIVRMIGICEAESWMLVM-EMAELGPLNKYLQQN----RHVKDKNIIELVHQVSMGMKY 484 P++VR + M++ E G L + +N H ++ + +++ Q+S+G+ Y Sbjct: 75 PHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNY 134 Query: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYY-------------KAQTH 531 + S+ VH D+ N+ + H + G+ + + + +++ A + Sbjct: 135 IHNSSMVHLDIKPSNIFIC--HKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSI 192 Query: 532 GKWPV-----KWYAPECINY-YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAML 585 K V ++ A E + Y+ K+D+++ G+ + A P G + Sbjct: 193 NKPKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHHI---- 248 Query: 586 EKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 KG P L+ D E RP AA+ Sbjct: 249 RKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAAL 285 >3BGP-A nrPDB Length = 333 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 51/209 (24%), Positives = 100/209 (47%), Gaps = 22/209 (10%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDEL------LAEANVMQQLDNP 430 LGSG FG+V G +V + V I E + + EL E +++++ + Sbjct: 64 LGSGGFGSVYSGI----RVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG 119 Query: 431 Y--IVRMIGICE-AESWMLVMEMAE-LGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE 486 + ++R++ E +S++L++E E + L ++ + ++++ QV +++ Sbjct: 120 FSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH 179 Query: 487 ESNFVHRDLAARNVLL-VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 +HRD+ N+L+ + + K+ DFG S AL D Y T + PE I Sbjct: 180 NCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVY----TDFDGTRVYSPPEWIR 234 Query: 546 YYKFSSKS-DVWSFGVLMWEAFSYGQKPY 573 Y+++ +S VWS G+L+++ G P+ Sbjct: 235 YHRYHGRSAAVWSLGILLYDMVC-GDIPF 262 >4RC3-A nrPDB Length = 289 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 51/209 (24%), Positives = 100/209 (47%), Gaps = 22/209 (10%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDEL------LAEANVMQQLDNP 430 LGSG FG+V G +V + V I E + + EL E +++++ + Sbjct: 20 LGSGGFGSVYSGI----RVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG 75 Query: 431 Y--IVRMIGICE-AESWMLVMEMAE-LGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE 486 + ++R++ E +S++L++E E + L ++ + ++++ QV +++ Sbjct: 76 FSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH 135 Query: 487 ESNFVHRDLAARNVLL-VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 +HRD+ N+L+ + + K+ DFG S AL D Y T + PE I Sbjct: 136 NCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVY----TDFDGTRVYSPPEWIR 190 Query: 546 YYKFSSKS-DVWSFGVLMWEAFSYGQKPY 573 Y+++ +S VWS G+L+++ G P+ Sbjct: 191 YHRYHGRSAAVWSLGILLYDMVC-GDIPF 218 >5UNP-A nrPDB Length = 369 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 55/239 (23%), Positives = 98/239 (41%), Gaps = 40/239 (16%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL-----DNPY 431 LG G FG V + + + VA+KI+KN K+ E NV++++ DN Sbjct: 42 LGEGTFGRVVQCVDHRRGGAR-VALKIIKNVEK---YKEAARLEINVLEKINEKDPDNKN 97 Query: 432 I-VRMIGICEAESWMLV-MEMAELGPLNKYLQQNRHVK--DKNIIELVHQVSMGMKYLEE 487 + V+M + M + E+ L + +L+ N ++ + + Q+ +K+L + Sbjct: 98 LCVQMFDWFDYHGHMCISFELLGLSTFD-FLKDNNYLPYPIHQVRHMAFQLCQAVKFLHD 156 Query: 488 SNFVHRDLAARNVLLVTQHY-------------------AKISDFGLSKALRADENYYKA 528 + H DL N+L V Y ++ DFG + + + Sbjct: 157 NKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVS 216 Query: 529 QTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 H + APE I +S DVWS G +++E + G ++ E AM+E+ Sbjct: 217 TRH------YRAPEVILELGWSQPCDVWSIGCIIFEYYV-GFTLFQTHDNREHLAMMER 268 >4E7W-A nrPDB Length = 394 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 60/247 (24%), Positives = 108/247 (43%), Gaps = 37/247 (14%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K +G+G+FG V + K+V++ V I K D K+ E +M+ + +P +V Sbjct: 46 KVIGNGSFGVVFQA-----KLVESDEVAI-KKVLQDKRFKNR---ELQIMRIVKHPNVVD 96 Query: 435 MIGIC----EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELV------HQVSMGMKY 484 + + + + + + E P Y + K K + ++ +Q+ + Y Sbjct: 97 LKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAY 156 Query: 485 LEESNFVHRDLAARNVLL-VTQHYAKISDFGLSKALRADE---NYYKAQTHGKWPVKWYA 540 + HRD+ +N+LL K+ DFG +K L A E +Y ++ + A Sbjct: 157 IHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRY-------YRA 209 Query: 541 PECI-NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR 599 PE I +++ D+WS G +M E GQ + G G + ++E + +G P+ R Sbjct: 210 PELIFGATNYTTNIDIWSTGCVMAELMQ-GQPLFPGESG--IDQLVEIIKVLGTPS---R 263 Query: 600 EMYDLMN 606 E MN Sbjct: 264 EQIKTMN 270 >5J0A-A nrPDB Length = 300 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 51/186 (27%), Positives = 87/186 (46%), Gaps = 23/186 (12%) Query: 400 AVKILKNEAND---PALKDELLAEANVMQQLDNPYIVRMIGICEAE--SWMLVMEMAELG 454 AVK + ND + L+ EA +++ L +P IV EA S L ME Sbjct: 41 AVKKINPICNDHYRSVYQKRLMDEAKILKSLHHPNIVGYRAFTEANDGSLCLAMEYGGEK 100 Query: 455 PLNKYLQQNRHVKDKN------IIELVHQVSMGMKYL-EESNFVHRDLAARNVLLVTQ-H 506 LN +++ R+ ++ I+++ ++ G+KYL +E +H D+ + NV++ Sbjct: 101 SLNDLIEE-RYKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFE 159 Query: 507 YAKISDFGLSKALRADENYY----KAQTHGKWPVKWYAPECINYYK-FSSKSDVWSFGVL 561 KI D G+S L DEN +A G P W E + + K+D+++FG+ Sbjct: 160 TIKICDVGVS--LPLDENMEVTDPEACYIGTEP--WKPKEAVEENGVITDKADIFAFGLT 215 Query: 562 MWEAFS 567 +WE + Sbjct: 216 LWEMMT 221 >6ED6-A nrPDB Length = 415 Score = 46.6 bits (109), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 51/211 (24%), Positives = 92/211 (43%), Gaps = 24/211 (11%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKN----EANDPALKDELLAEANVMQQLDNP 430 K +G G FG V+ + K K A+K+L + +D A E ++M ++P Sbjct: 94 KVIGRGAFGEVQ--LVRHKASQKVYAMKLLSKFEMIKRSDSAF---FWEERDIMAFANSP 148 Query: 431 YIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 ++V++ + + ++ +VME G L L N V +K +V + + + Sbjct: 149 WVVQLFYAFQDDRYLYMVMEYMPGGDLVN-LMSNYDVPEKWAKFYTAEVVLALDAIHSMG 207 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPV---KWYAPECINY 546 +HRD+ N+LL + K++DFG ++ DE H V + +PE + Sbjct: 208 LIHRDVKPDNMLLDKHGHLKLADFG--TCMKMDET---GMVHCDTAVGTPDYISPEVLKS 262 Query: 547 YK----FSSKSDVWSFGVLMWEAFSYGQKPY 573 + + D WS GV ++E G P+ Sbjct: 263 QGGDGFYGRECDWWSVGVFLYEML-VGDTPF 292 >4XHL-A nrPDB Length = 394 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 63/265 (23%), Positives = 115/265 (43%), Gaps = 31/265 (11%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +++GSG+FG + G + + VA+++ + P L E + + P+I R Sbjct: 13 RKIGSGSFGDIYHGTNLISG--EEVAIRLESIRSRHPQLDYESRVYRYLSGGVGIPFI-R 69 Query: 435 MIGICEAESWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 G E E +V+++ LGP + L +R K +I L Q+ ++Y+ +F+H Sbjct: 70 WFG-REGEYNAMVIDL--LGPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQYIHGRSFIH 126 Query: 493 RDLAARNVLL------VTQHYAKISDFGLSKALRADENY----YKAQTHGKWPVKWYAPE 542 RD+ N L+ T H + DFGLSK R + Y+ ++ + Sbjct: 127 RDIKPDNFLMGVGRRGSTVH---VIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVN 183 Query: 543 CINYYKFSSKSDVWSFG-VLMWEAFSYGQKPYRGMKGS----EVTAMLEKGERMGCPAGC 597 + S + D+ S G VL++ F G P++G+K + + ++EK + C Sbjct: 184 THLGIEQSRRDDLESLGYVLIY--FCKGSLPWQGLKATTKKQKYDRIMEKKLNVSVETLC 241 Query: 598 ---PREMYDLMNLCWTYDVENRPGF 619 P E + M C + +P + Sbjct: 242 SGLPLEFQEYMAYCKNLKFDEKPDY 266 >4C59-A nrPDB Length = 340 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 43/194 (22%), Positives = 92/194 (47%), Gaps = 31/194 (15%) Query: 408 ANDPALKDELLAEANVMQQLD-NPYIVRM-----IGICEAES----WMLVMEMAELGPLN 457 +N+ ++ E M++L +P IV+ IG E+++ ++L+ E+ + G L Sbjct: 62 SNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCK-GQLV 120 Query: 458 KYLQQNRH---VKDKNIIELVHQVSMGMKYL--EESNFVHRDLAARNVLLVTQHYAKISD 512 ++L++ + ++++ +Q ++++ ++ +HRDL N+LL Q K+ D Sbjct: 121 EFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCD 180 Query: 513 FGLSKALRADENY-YKAQ---------THGKWPVKWYAPECINYYK---FSSKSDVWSFG 559 FG + + +Y + AQ T P+ + PE I+ Y K D+W+ G Sbjct: 181 FGSATTISHYPDYSWSAQRRALVEEEITRNTTPM-YRTPEIIDLYSNFPIGEKQDIWALG 239 Query: 560 VLMWEAFSYGQKPY 573 +++ + Q P+ Sbjct: 240 CILY-LLCFRQHPF 252 >6FYV-A nrPDB Length = 337 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 55/240 (22%), Positives = 99/240 (41%), Gaps = 42/240 (17%) Query: 377 LGSGNFGTVKKGY-YQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 LG G FG V + + M + VAVKI+KN ++ +E V++ L++ + Sbjct: 22 LGEGAFGKVVECIDHGMDGM--HVAVKIVKNVGR---YREAARSEIQVLEHLNSTDPNSV 76 Query: 436 IGICEAESWM-------LVMEMAELGPLNKYLQQNRHV--KDKNIIELVHQVSMGMKYLE 486 + W +V E+ L + ++++N + + +I ++ +Q+ + +L Sbjct: 77 FRCVQMLEWFDHHGHVCIVFELLGLSTYD-FIKENSFLPFQIDHIRQMAYQICQSINFLH 135 Query: 487 ESNFVHRDLAARNVLLVTQHYA-------------------KISDFGLSKALRADENYYK 527 + H DL N+L V Y K+ DFG A DE++ Sbjct: 136 HNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFG--SATYDDEHHST 193 Query: 528 AQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 + + APE I +S DVWS G ++ E + G ++ E AM+E+ Sbjct: 194 LVS----TRHYRAPEVILALGWSQPCDVWSIGCILIEYY-LGFTVFQTHDSKEHLAMMER 248 >5E8V-A nrPDB Length = 316 Score = 45.8 bits (107), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 73/308 (23%), Positives = 121/308 (39%), Gaps = 54/308 (17%) Query: 366 DRKLLTLE-DKELGSGNFGTVKKGYYQ--MKKVVKTVAVKILKNE------ANDPALKDE 416 + +LL +E D +G G F V K + + +TVAVKI E D Sbjct: 5 NTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDI 64 Query: 417 LLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKD-KNIIELV 475 L N++Q L +G + W++ A+ G L +YL RHV +++ +L Sbjct: 65 NLKHENILQFLTAEERKTELG---KQYWLITAFHAK-GNLQEYL--TRHVISWEDLRKLG 118 Query: 476 HQVSMGMKYLEESN---------FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYY 526 ++ G+ +L + VHRDL + N+L+ + DFGLS L + Sbjct: 119 SSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVD 178 Query: 527 KAQTHGKW-PVKWYAPECI-------NYYKFSSKSDVWSFGVLMWEAFSYGQ-------- 570 G+ ++ APE + N F ++DV+S +++WE S Sbjct: 179 DLANSGQVGTARYMAPEVLASAMNLENVESF-KQTDVYSMALVLWEMTSRCNAVGEVKDY 237 Query: 571 KPYRGMKGSEVTAMLEKGERMGCPAGCP------------REMYDLMNLCWTYDVENRPG 618 +P G K E + + + AG P + + + + CW +D E R Sbjct: 238 EPPFGSKVREHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLT 297 Query: 619 FAAVELRL 626 V R Sbjct: 298 AQCVAERF 305 >2WO6-A nrPDB Length = 382 Score = 45.1 bits (105), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 64/246 (26%), Positives = 105/246 (42%), Gaps = 23/246 (9%) Query: 358 IRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEA---NDPALK 414 ++ E ++DR + D +G G+FG V K Y ++++ + VA+KI+KN+ N ++ Sbjct: 46 VKNGEKWMDRYEI---DSLIGKGSFGQVVKAYDRVEQ--EWVAIKIIKNKKAFLNQAQIE 100 Query: 415 DELLAEANVMQQLDNPYIVRMI-GICEAESWMLVMEMAELGPLNKYLQQN-RHVKDKNII 472 LL N YIV + LV EM + N R V Sbjct: 101 VRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTR 160 Query: 473 ELVHQVSMGMKYLE--ESNFVHRDLAARNVLLVT--QHYAKISDFGLSKALRADENYYKA 528 + Q+ + +L E + +H DL N+LL + KI DFG S L Y Sbjct: 161 KFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQL-GQRIYQYI 219 Query: 529 QTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG 588 Q+ + +PE + + D+WS G ++ E + G+ + G +EV M + Sbjct: 220 QSRF-----YRSPEVLLGMPYDLAIDMWSLGCILVEMHT-GEPLFSG--ANEVDQMNKIV 271 Query: 589 ERMGCP 594 E +G P Sbjct: 272 EVLGIP 277 >2LQW-A nrPDB Length = 303 Score = 45.1 bits (105), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 37/143 (25%), Positives = 59/143 (41%), Gaps = 5/143 (3%) Query: 3 SSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAH 62 SS DS++ ++ G ++R+EA+ L G G++L+R S G + LSV+ + Sbjct: 2 SSARFDSSDRSAWYMGPVSRQEAQTRL--QGQRHGMFLVRDSSTCPGDYVLSVSENSRVS 59 Query: 63 HYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKP-FNRPQGVQPKTGPFE 121 HY I N + I PA L Y D + P + P Sbjct: 60 HYIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPMGSVSAPNLP 119 Query: 122 DLKENLIREYVKQTWNLQGQALE 144 ++NL EYV+ ++ G E Sbjct: 120 TAEDNL--EYVRTLYDFPGNDAE 140 Score = 38.5 bits (88), Expect = 0.010, Method: Compositional matrix adjust. Identities = 26/84 (30%), Positives = 44/84 (52%), Gaps = 4/84 (4%) Query: 162 AHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDN-NGSYALCLLHEGKVLHYRIDK 220 + ++ W+ G +SR+E+ Q L G + +G FL+R G Y L + +V HY I+ Sbjct: 8 SSDRSAWYMGPVSRQEA-QTRLQGQR-HGMFLVRDSSTCPGDYVLSVSENSRVSHYIINS 65 Query: 221 DKTGKLSIPEGKKFDTLWQLVEHY 244 + I + ++FD L L+E Y Sbjct: 66 LPNRRFKIGD-QEFDHLPALLEFY 88 >3E3P-A nrPDB Length = 360 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 65/266 (24%), Positives = 110/266 (41%), Gaps = 47/266 (17%) Query: 378 GSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIG 437 G G FGTV+ G + K +VA+K + DP ++ L + L +P IV++ Sbjct: 32 GQGTFGTVQLG--KEKSTGMSVAIKKV---IQDPRFRNRELQIMQDLAVLHHPNIVQL-- 84 Query: 438 ICEAESWMLVMEMAE-----LGPLNKYLQQNRHVKDKN----------------IIELVH 476 +S+ + + L + +Y+ H +N + +L+ Sbjct: 85 ----QSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFLFQLIR 140 Query: 477 QVSMGMKYLEESNFVHRDLAARNVLL-VTQHYAKISDFGLSKALRADENYYKAQTHGKWP 535 S+G +L N HRD+ NVL+ K+ DFG +K L E A ++ Sbjct: 141 --SIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNV-AYICSRY- 196 Query: 536 VKWYAPECI-NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP 594 + APE I +++ D+WS G + E G+ +RG + + E +GCP Sbjct: 197 --YRAPELIFGNQHYTTAVDIWSVGCIFAEMM-LGEPIFRG--DNSAGQLHEIVRVLGCP 251 Query: 595 AGCPREMYDLMNLCWT-YDVENRPGF 619 + RE+ +N T D+ N G Sbjct: 252 S---REVLRKLNPSHTDVDLYNSKGI 274 >1ZXE-A nrPDB Length = 303 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 52/238 (21%), Positives = 92/238 (38%), Gaps = 49/238 (20%) Query: 377 LGSGNFGTVKKG-------YYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDN 429 LG G FG V K YY +KK+ T + L +L+E ++ L++ Sbjct: 14 LGQGAFGQVVKARNALDSRYYAIKKIRHT-----------EEKLS-TILSEVMLLASLNH 61 Query: 430 PYIVR--------------MIGICEAESWMLVMEMAELGPLNKYLQ-QNRHVKDKNIIEL 474 Y+VR M + + + + ME E L + +N + + L Sbjct: 62 QYVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRL 121 Query: 475 VHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQ----- 529 Q+ + Y+ +HR+L N+ + KI DFGL+K + + K Sbjct: 122 FRQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLP 181 Query: 530 ------THGKWPVKWYAPECIN-YYKFSSKSDVWSFGVLMWEA---FSYGQKPYRGMK 577 T + A E ++ ++ K D++S G++ +E FS G + +K Sbjct: 182 GSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIYPFSTGMERVNILK 239 >1RPY-A nrPDB Length = 114 Score = 44.3 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 24/80 (30%), Positives = 45/80 (56%), Gaps = 3/80 (3%) Query: 167 PWFHGKISREESEQIVLIGS-KTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDKTG 224 PWFHG +SR ++ Q+VL G +++G F+IR + G L +GK H R+ + G Sbjct: 12 PWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTFNFQGKAKHLRLSLNGHG 71 Query: 225 KLSIPEGKKFDTLWQLVEHY 244 + + + F +++ ++ H+ Sbjct: 72 QCHV-QHLWFQSVFDMLRHF 90 Score = 33.1 bits (74), Expect = 0.39, Method: Composition-based stats. Identities = 21/60 (35%), Positives = 32/60 (53%), Gaps = 3/60 (5%) Query: 14 PFFFGNITREEAEDYLVQGG-MSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNG 72 P+F G ++R +A ++ GG S GL+++RQS G L+ KA H + LNG Sbjct: 12 PWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTFNFQGKAKHLRL--SLNG 69 >5TE0-A nrPDB Length = 347 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 27/97 (27%), Positives = 45/97 (46%), Gaps = 19/97 (19%) Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVK----------WY 539 +HRDL N+LL + + + DFG A + QT G V+ + Sbjct: 147 IIHRDLKVENILLHDRGHYVLCDFG-----SATNKFQNPQTEGVNAVEDEIKKYTTLSYR 201 Query: 540 APECINYYK---FSSKSDVWSFGVLMWEAFSYGQKPY 573 APE +N Y ++K+D+W+ G L+++ Y P+ Sbjct: 202 APEMVNLYSGKIITTKADIWALGCLLYK-LCYFTLPF 237 >5VD3-A nrPDB Length = 311 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 55/234 (23%), Positives = 100/234 (42%), Gaps = 16/234 (6%) Query: 345 TEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKIL 404 +E +SP DP RP E + + L LG G++G V K + K+ + AVK Sbjct: 38 SETLQSPGYDPS--RP-ESFFQQSFQRL--SRLGHGSYGEVFK--VRSKEDGRLYAVKRS 90 Query: 405 KNEANDPALKDELLAEANVMQQL-DNPYIVRMIGICEAESWMLVMEMAELGP-LNKYLQQ 462 + P + LAE +++ +P VR+ E E +L ++ GP L ++ + Sbjct: 91 MSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWE-EGGILYLQTELCGPSLQQHCEA 149 Query: 463 -NRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRA 521 + + + + + + +L VH D+ N+ L + K+ DFGL L Sbjct: 150 WGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVEL-- 207 Query: 522 DENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG 575 A + ++ APE + + + +DV+S G+ + E + P+ G Sbjct: 208 --GTAGAGEVQEGDPRYMAPELLQ-GSYGTAADVFSLGLTILEVACNMELPHGG 258 >2CS0-A nrPDB Length = 119 Score = 43.5 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 34/103 (33%), Positives = 50/103 (48%), Gaps = 5/103 (4%) Query: 162 AHEKMP-WFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDK 220 A + +P WFHG ISRE++E L+ S+ G FLIR ++ Y L + H+ + Sbjct: 11 AQDGVPEWFHGAISREDAEN--LLESQPLGSFLIRVSHSHVGYTLSYKAQSSCCHFMVKL 68 Query: 221 DKTGKLSIP-EGKKFDTLWQLVEHYSYKADGLLR-VLTVPCQK 261 G IP E +L LV + K R +LT PC++ Sbjct: 69 LDDGTFMIPGEKVAHTSLDALVTFHQQKPIEPRRELLTQPCRQ 111 >5X8I-B nrPDB Length = 346 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 56/236 (23%), Positives = 97/236 (41%), Gaps = 34/236 (14%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKN-EANDPALKDEL--LAEANVMQQLDNPYIV 433 LG G FG V + K + VAVKI+KN + A + E+ L N V Sbjct: 21 LGEGAFGKVVECI-DHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCV 79 Query: 434 RMIGICEAESWM-LVMEMAELGPLNKYLQQNRHV--KDKNIIELVHQVSMGMKYLEESNF 490 +M+ E + +V E+ L + ++++N + + +I ++ +Q+ + +L + Sbjct: 80 QMLEWFEHHGHICIVFELLGLSTYD-FIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKL 138 Query: 491 VHRDLAARNVLLVTQHYA-------------------KISDFGLSKALRADENYYKAQTH 531 H DL N+L V Y K+ DFG + D+ ++ Sbjct: 139 THTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFG---SATYDDEHHSTLVS 195 Query: 532 GKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 + + APE I +S DVWS G ++ E + G + E AM+E+ Sbjct: 196 TR---HYRAPEVILALGWSQPCDVWSIGCILIEYY-LGFTVFPTHDSKEHLAMMER 247 >2B3O-A nrPDB Length = 532 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 30/87 (34%), Positives = 50/87 (57%), Gaps = 4/87 (4%) Query: 168 WFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHYRIDKDKTGKL 226 WFH +S ++E + L G +G FL R +R N G ++L + +V H RI ++ Sbjct: 4 WFHRDLSGLDAETL-LKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRI-QNSGDFY 61 Query: 227 SIPEGKKFDTLWQLVEHYSYKADGLLR 253 + G+KF TL +LVE+Y+ + G+L+ Sbjct: 62 DLYGGEKFATLTELVEYYT-QQQGVLQ 87 Score = 42.0 bits (97), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 31/100 (31%), Positives = 49/100 (49%), Gaps = 8/100 (8%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74 +F +++ +AE L++G G +L R SR G F+LSV G + H I+ Y Sbjct: 4 WFHRDLSGLDAET-LLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNS-GDFY 61 Query: 75 AIAGGRTHASPADLCHYHSQES------DGLVCLLKKPFN 108 + GG A+ +L Y++Q+ DG + LK P N Sbjct: 62 DLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLN 101 >3PS5-A nrPDB Length = 595 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 28/79 (35%), Positives = 45/79 (56%), Gaps = 3/79 (3%) Query: 168 WFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHYRIDKDKTGKL 226 WFH +S ++E + L G +G FL R +R N G ++L + +V H RI ++ Sbjct: 4 WFHRDLSGLDAETL-LKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRI-QNSGDFY 61 Query: 227 SIPEGKKFDTLWQLVEHYS 245 + G+KF TL +LVE+Y+ Sbjct: 62 DLYGGEKFATLTELVEYYT 80 Score = 42.0 bits (97), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 31/100 (31%), Positives = 49/100 (49%), Gaps = 8/100 (8%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74 +F +++ +AE L++G G +L R SR G F+LSV G + H I+ Y Sbjct: 4 WFHRDLSGLDAET-LLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNS-GDFY 61 Query: 75 AIAGGRTHASPADLCHYHSQES------DGLVCLLKKPFN 108 + GG A+ +L Y++Q+ DG + LK P N Sbjct: 62 DLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLN 101 >6CMQ-A nrPDB Length = 427 Score = 42.7 bits (99), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 35/109 (32%), Positives = 54/109 (49%), Gaps = 18/109 (16%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHG----------RKAHHY 64 +F G+++ +EAE L + G G +L+R+S+++ G F LSV G K H Sbjct: 10 WFHGHLSGKEAEKLLTEKG-KHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHV 68 Query: 65 TIE-RELNGTYAIAGGRTHASPADLCHYHSQ----ESDGLVCLLKKPFN 108 I +EL Y + GG S DL ++ + E+ G V LK+P N Sbjct: 69 MIRCQELK--YDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLN 115 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 28/88 (31%), Positives = 48/88 (54%), Gaps = 13/88 (14%) Query: 168 WFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCLLH----------EGKVLHY 216 WFHG +S +E+E+++ K +G FL+R ++ + G + L + + KV H Sbjct: 10 WFHGHLSGKEAEKLLTEKGK-HGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHV 68 Query: 217 RIDKDKTGKLSIPEGKKFDTLWQLVEHY 244 I + + K + G++FD+L LVEHY Sbjct: 69 MI-RCQELKYDVGGGERFDSLTDLVEHY 95 >5M6U-B nrPDB Length = 724 Score = 42.7 bits (99), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 26/86 (30%), Positives = 44/86 (51%), Gaps = 2/86 (2%) Query: 163 HEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDK 222 H++ W G +R ++E L+ K +G FL+R G YA ++ +G+V H I+K Sbjct: 619 HDEKTWNVGSSNRNKAEN--LLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTA 676 Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKA 248 TG + +L +LV HY + + Sbjct: 677 TGYGFAEPYNLYSSLKELVLHYQHTS 702 >1MIL-A nrPDB Length = 104 Score = 42.4 bits (98), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 29/91 (31%), Positives = 47/91 (51%), Gaps = 10/91 (10%) Query: 167 PWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDKTGK 225 PWFHGK+SR E+E ++ + NG FL+R G Y L L G+ H + D G Sbjct: 8 PWFHGKLSRREAEALL----QLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLL-VDPEGV 62 Query: 226 LSIPEGKKFDTLWQLVEHYSYKADGLLRVLT 256 + + +F+++ L+ SY D L +++ Sbjct: 63 VRTKD-HRFESVSHLI---SYHMDNHLPIIS 89 >5CEK-A nrPDB Length = 263 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 33/161 (20%), Positives = 73/161 (45%), Gaps = 6/161 (3%) Query: 432 IVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFV 491 I ++ + E+ V + G ++ Y++ + ++++ L Q+ + + +S V Sbjct: 63 ITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIV 122 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKA-LRADENYYKAQTHGKWPVKWYAPECINYY-KF 549 DL R + T+ ++ L + E+ + HG P + +PE +N + Sbjct: 123 LGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHG-CPA-YVSPEILNTTGTY 180 Query: 550 SSKS-DVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 S K+ DVWS GV+++ G+ P+ S + + + +G+ Sbjct: 181 SGKAADVWSLGVMLYTLL-VGRYPFHDSDPSALFSKIRRGQ 220 >3RAW-A nrPDB Length = 381 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 49/243 (20%), Positives = 97/243 (39%), Gaps = 48/243 (19%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL-----DNPY 431 LG G FG V + + + VA+KI++N ++ E NV++++ +N + Sbjct: 59 LGEGTFGKVVECLDHARGKSQ-VALKIIRNVGK---YREAARLEINVLKKIKEKDKENKF 114 Query: 432 IVRMIGICEAESWMLVMEMAELGPLN-KYLQQNR-------HVKDKNIIELVHQVSMGMK 483 + ++ + + LG ++L++N HV+ + +Q+ ++ Sbjct: 115 LCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVR-----HMAYQLCHALR 169 Query: 484 YLEESNFVHRDLAARNVLLVTQHY-------------------AKISDFGLSKALRADEN 524 +L E+ H DL N+L V + +++DFG + Sbjct: 170 FLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHT 229 Query: 525 YYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAM 584 A H + PE I ++ DVWS G +++E + G ++ + E M Sbjct: 230 TIVATRH------YRPPEVILELGWAQPCDVWSIGCILFEYYR-GFTLFQTHENREHLVM 282 Query: 585 LEK 587 +EK Sbjct: 283 MEK 285 >2PMN-X nrPDB Length = 348 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 51/221 (23%), Positives = 94/221 (42%), Gaps = 27/221 (12%) Query: 375 KELGSGNFGTV-----KKGYYQMKKVVKTVAVK---ILKNEANDPALK---DELLAEANV 423 + L G F + +Y +KK K++ K K+ + ++K D+ E + Sbjct: 37 RTLNQGKFNKIILCEKDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKYDDFKNELQI 96 Query: 424 MQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDKN---------IIE 473 + + N Y + GI + ++ E E + K+ + V DKN I Sbjct: 97 ITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKF-DEYFFVLDKNYTCFIPIQVIKC 155 Query: 474 LVHQVSMGMKYL-EESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHG 532 ++ V Y+ E N HRD+ N+L+ K+SDFG S+ + + T+ Sbjct: 156 IIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMVDKKIKGSRGTYE 215 Query: 533 KWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPY 573 P ++++ E + Y +K D+WS G+ ++ F Y P+ Sbjct: 216 FMPPEFFSNE--SSYN-GAKVDIWSLGICLYVMF-YNVVPF 252 >6DC0-A nrPDB Length = 292 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 33/161 (20%), Positives = 73/161 (45%), Gaps = 6/161 (3%) Query: 432 IVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFV 491 I ++ + E+ V + G ++ Y++ + ++++ L Q+ + + +S V Sbjct: 60 ITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIV 119 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKA-LRADENYYKAQTHGKWPVKWYAPECINYY-KF 549 DL R + T+ ++ L + E+ + HG P + +PE +N + Sbjct: 120 LGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHG-CPA-YVSPEILNTTGTY 177 Query: 550 SSKS-DVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 S K+ DVWS GV+++ G+ P+ S + + + +G+ Sbjct: 178 SGKAADVWSLGVMLYTLL-VGRYPFHDSDPSALFSKIRRGQ 217 >2CMW-A nrPDB Length = 310 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 41/150 (27%), Positives = 69/150 (46%), Gaps = 12/150 (8%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K++G GNFG ++ G + + VA+K+ ++ P L E + + V Sbjct: 6 KKIGCGNFGELRLG--KNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVY 63 Query: 435 MIGICEAESWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 G C + M V+E+ LGP + L +R K ++ + Q+ M+Y+ N ++ Sbjct: 64 YFGPCGKYNAM-VLEL--LGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIY 120 Query: 493 RDLAARNVLLVTQ-----HYAKISDFGLSK 517 RD+ N L+ Q H I DFGL+K Sbjct: 121 RDVKPENFLIGRQGNKKEHVIHIIDFGLAK 150 >3CXL-A nrPDB Length = 463 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 39/135 (28%), Positives = 65/135 (48%), Gaps = 25/135 (18%) Query: 124 KENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMP-----WFHGKISREES 178 +ENL Y + W L+Q + P ++ T E P FHG ISRE + Sbjct: 11 RENL---YFQGVWKSYLYQLQQ----EAPHPRRITCTCEVENRPKYYGREFHGMISREAA 63 Query: 179 EQIVLIGSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTL 237 +Q++++ G +LIR ++ G+Y L L + ++R+ D GK + E K+F+++ Sbjct: 64 DQLLIVAE---GSYLIRESQRQPGTYTLALRFGSQTRNFRLYYD--GKHFVGE-KRFESI 117 Query: 238 WQLVEHYSYKADGLL 252 LV DGL+ Sbjct: 118 HDLV------TDGLI 126 Score = 32.3 bits (72), Expect = 0.59, Method: Compositional matrix adjust. Identities = 22/87 (25%), Positives = 44/87 (50%), Gaps = 12/87 (13%) Query: 16 FFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYA 75 F G I+RE A+ L+ +++G YL+R+S+ G + L++ G + ++ + +G + Sbjct: 54 FHGMISREAADQLLI---VAEGSYLIRESQRQPGTYTLALRFGSQTRNFRL--YYDGKHF 108 Query: 76 IAGGRTHASPADLCHYHSQESDGLVCL 102 + R + H +DGL+ L Sbjct: 109 VGEKRFES-------IHDLVTDGLITL 128 >5IKW-A nrPDB Length = 310 Score = 39.3 bits (90), Expect = 0.005, Method: Compositional matrix adjust. Identities = 24/83 (28%), Positives = 41/83 (49%), Gaps = 8/83 (9%) Query: 490 FVHRDLAARNVLLVTQHYAKISDFG--LSKALRADE---NYYKAQTHGKWPVKWYAPECI 544 +HRDL N+LL + DFG +K L + N + + + + APE I Sbjct: 141 IIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMI 200 Query: 545 NYY---KFSSKSDVWSFGVLMWE 564 N Y ++K+D+W+ G L+++ Sbjct: 201 NLYGGKPITTKADIWALGCLLYK 223 >2C47-A nrPDB Length = 313 Score = 39.3 bits (90), Expect = 0.005, Method: Compositional matrix adjust. Identities = 52/230 (22%), Positives = 97/230 (42%), Gaps = 30/230 (13%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K++G GNFG ++ G + ++ +K+ A L+ + + + + Y Sbjct: 10 KKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVY--- 66 Query: 435 MIGICEAESWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 G C + M V+E+ LGP + L +R K ++ + Q+ M+Y+ + ++ Sbjct: 67 YFGPCGKYNAM-VLEL--LGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIY 123 Query: 493 RDLAARNVLL-----VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP------ 541 RD+ N L+ QH I DFGL+K Y +T P + + Sbjct: 124 RDVKPENFLVGRPGTKRQHAIHIIDFGLAK------EYIDPETKKHIPYREHKSLTGTAR 177 Query: 542 -ECINYY---KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 IN + + S + D+ + G M+ F G P++G+K + +K Sbjct: 178 YMSINTHLGKEQSRRDDLEALGH-MFMYFLRGSLPWQGLKADTLKERYQK 226 >4NT4-A nrPDB Length = 312 Score = 38.9 bits (89), Expect = 0.007, Method: Compositional matrix adjust. Identities = 51/227 (22%), Positives = 94/227 (41%), Gaps = 18/227 (7%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDN----- 429 K++G GNFG ++ G + VA+K+ ++ P L E + DN Sbjct: 18 KKIGCGNFGELRLGKNLYNN--EHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAPDGI 75 Query: 430 PYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 P I + G C +V+E+ L + + R K ++ + Q+ ++Y+ + Sbjct: 76 PRIYHL-GTCGGRYNAMVLELLGLSLEDLFNICARKFSLKTVLMIAKQLLHRIEYVHSRH 134 Query: 490 FVHRDLAARNVLL-----VTQHYAKISDFGLSKA-LRADENYYKAQTHGKWPVKWYAPEC 543 ++RD+ N L+ + I DFGL+K + D N + K Sbjct: 135 LIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTARYMS 194 Query: 544 INYY---KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 IN + + S + D+ + G M+ F G P++G+K + +K Sbjct: 195 INTHMGREQSRRDDLEALGH-MFMYFLRGSLPWQGLKADTLKERYQK 240 >5VC6-A nrPDB Length = 289 Score = 38.9 bits (89), Expect = 0.007, Method: Compositional matrix adjust. Identities = 32/137 (23%), Positives = 64/137 (46%), Gaps = 10/137 (7%) Query: 373 EDKELGSGNFGTVKKGYYQMKKVVKTV--AVKILKNEANDPALKDELLAEANVMQQLDNP 430 E +++GSG FG+V K ++ + + + K L ++ E+ A A + Q + Sbjct: 15 ELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQ---HS 71 Query: 431 YIVRMIGICEAESWMLVM-EMAELGPLNKYLQQNRHV----KDKNIIELVHQVSMGMKYL 485 ++VR + ML+ E G L + +N + K+ + +L+ QV G++Y+ Sbjct: 72 HVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYI 131 Query: 486 EESNFVHRDLAARNVLL 502 + VH D+ N+ + Sbjct: 132 HSMSLVHMDIKPSNIFI 148 >2CHL-A nrPDB Length = 351 Score = 38.1 bits (87), Expect = 0.011, Method: Compositional matrix adjust. Identities = 58/233 (24%), Positives = 100/233 (42%), Gaps = 36/233 (15%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL---DNPY 431 K++G GNFG ++ G + + VA+K+ ++ P +L E +QL D Sbjct: 36 KKIGCGNFGELRLG--KNLYTNEYVAIKLEPMKSRAP----QLHLEYRFYKQLGSGDGIP 89 Query: 432 IVRMIGICEAESWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGMKYLEESN 489 V G C + M V+E+ LGP + L +R K ++ + Q+ M+Y+ N Sbjct: 90 QVYYFGPCGKYNAM-VLEL--LGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKN 146 Query: 490 FVHRDLAARNVLL-----VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP--- 541 ++RD+ N L+ TQ I DF L+K Y +T P + + Sbjct: 147 LIYRDVKPENFLIGRPGNKTQQVIHIIDFALAK------EYIDPETKKHIPYREHKSLTG 200 Query: 542 ----ECINYY---KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 IN + + S + D+ + G M+ F G P++G+K + +K Sbjct: 201 TARYMSINTHLGKEQSRRDDLEALGH-MFMYFLRGSLPWQGLKADTLKERYQK 252 >4L68-A nrPDB Length = 340 Score = 38.1 bits (87), Expect = 0.012, Method: Compositional matrix adjust. Identities = 44/174 (25%), Positives = 73/174 (41%), Gaps = 9/174 (5%) Query: 416 ELLAEANVMQQLDNPYIVRMIGICEAESW-MLVMEMAELGPLNKYLQQNRHVKD-KNIIE 473 E E N + +L + + ++G C E LV + G L+ L NR D Sbjct: 81 EFRYEMNQLWELRHSNLAPLLGFCVVEEEKFLVYKYMSNGTLHSLLDSNRGELDWSTRFR 140 Query: 474 LVHQVSMGMKYLEESN---FVHRDLAARNVLLVTQHYAKISDFGLSKALR-ADENYYKAQ 529 + + G+ +L +H+++ + +L+ A+I D GL++ + +D N Sbjct: 141 IGLGAARGLAWLHHGCRPPILHQNICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFM 200 Query: 530 THGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPY--RGMKGSEV 581 T + APE S K DV+ GV++ E + G K G KGS V Sbjct: 201 TGDLGEFGYVAPEYSTTMLASLKGDVYGLGVVLLE-LATGLKAVGGEGFKGSLV 253 >2KK6-A nrPDB Length = 116 Score = 37.7 bits (86), Expect = 0.015, Method: Compositional matrix adjust. Identities = 23/78 (29%), Positives = 40/78 (51%), Gaps = 7/78 (8%) Query: 168 WFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHYRIDKDKTGKL 226 W+HG I R E+++++ K G FL+R + G Y L + +G+ H+ I + Sbjct: 19 WYHGAIPRIEAQELL----KKQGDFLVRESHGKPGEYVLSVYSDGQRRHFII--QYVDNM 72 Query: 227 SIPEGKKFDTLWQLVEHY 244 EG F + QL++H+ Sbjct: 73 YRFEGTGFSNIPQLIDHH 90 >2EYZ-A nrPDB Length = 304 Score = 37.4 bits (85), Expect = 0.021, Method: Compositional matrix adjust. Identities = 20/63 (31%), Positives = 33/63 (52%), Gaps = 2/63 (3%) Query: 4 SGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHH 63 +G DS +++G ++R+EA L G G++L+R S G + LSV+ + H Sbjct: 2 AGNFDSEERSSWYWGRLSRQEAVALLQ--GQRHGVFLVRDSSTSPGDYVLSVSENSRVSH 59 Query: 64 YTI 66 Y I Sbjct: 60 YII 62 Score = 37.0 bits (84), Expect = 0.026, Method: Compositional matrix adjust. Identities = 18/59 (30%), Positives = 35/59 (59%), Gaps = 3/59 (5%) Query: 162 AHEKMPWFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHYRID 219 + E+ W+ G++SR+E+ + L+ + +G FL+R + + G Y L + +V HY I+ Sbjct: 7 SEERSSWYWGRLSRQEA--VALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIIN 63 >1XA6-A nrPDB Length = 466 Score = 37.4 bits (85), Expect = 0.021, Method: Compositional matrix adjust. Identities = 37/128 (28%), Positives = 59/128 (46%), Gaps = 20/128 (15%) Query: 130 EYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMP-----WFHGKISREESEQIVLI 184 EY W L+Q + P+ +++I E P FHG ISRE++++ L+ Sbjct: 18 EYQPPIWKSYLYQLQQ----EAPRPKRIICPREVENRPKYYGREFHGIISREQADE--LL 71 Query: 185 GSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHY 244 G L ++ G Y L L + L+YR+ D GK + E K+F+++ LV Sbjct: 72 GGVEGAYILRESQRQPGCYTLALRFGNQTLNYRLFHD--GKHFVGE-KRFESIHDLV--- 125 Query: 245 SYKADGLL 252 DGL+ Sbjct: 126 ---TDGLI 130 Score = 34.3 bits (77), Expect = 0.19, Method: Compositional matrix adjust. Identities = 27/87 (31%), Positives = 45/87 (51%), Gaps = 12/87 (13%) Query: 16 FFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYA 75 F G I+RE+A++ L GG+ +G Y+LR+S+ G + L++ G + +Y R + Sbjct: 58 FHGIISREQADELL--GGV-EGAYILRESQRQPGCYTLALRFGNQTLNY---RLFHDGKH 111 Query: 76 IAGGRTHASPADLCHYHSQESDGLVCL 102 G + S DL +DGL+ L Sbjct: 112 FVGEKRFESIHDLV------TDGLITL 132 >3LLT-A nrPDB Length = 360 Score = 37.0 bits (84), Expect = 0.028, Method: Compositional matrix adjust. Identities = 55/248 (22%), Positives = 102/248 (41%), Gaps = 52/248 (20%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +++G G FG V + K K AVK+++N EA++++++ N I Sbjct: 41 RKMGDGTFGRVLLCQHIDNK--KYYAVKVVRNIKK---YTRSAKIEADILKKIQNDDINN 95 Query: 435 MIGICEAESWM----LVMEMAELGP-LNKYLQQNR----HVKDKNIIELVHQVSMGMKYL 485 + +M + + LGP L + + +N H++D + + ++ + YL Sbjct: 96 NNIVKYHGKFMYYDHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCI--EILKALNYL 153 Query: 486 EESNFVHRDLAARNVLLVTQHY-------------------------AKISDFGLSKALR 520 + + H DL N+LL ++ K+ DFG + Sbjct: 154 RKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCAT--- 210 Query: 521 ADENYYKAQTHGKW--PVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKG 578 +K+ HG ++ APE I + SD+WSFG ++ E ++ G +R + Sbjct: 211 -----FKSDYHGSIINTRQYRAPEVILNLGWDVSSDMWSFGCVLAELYT-GSLLFRTHEH 264 Query: 579 SEVTAMLE 586 E AM+E Sbjct: 265 MEHLAMME 272 >5GZ9-A nrPDB Length = 305 Score = 36.2 bits (82), Expect = 0.040, Method: Compositional matrix adjust. Identities = 27/123 (21%), Positives = 60/123 (48%), Gaps = 6/123 (4%) Query: 370 LTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDN 429 L E ++L G VK+ + K K ++ + E +K++ L +++ L + Sbjct: 32 LRTEVRQLKRVGEGAVKRVFLSEWKEHKVALSRLTRLE-----MKEDFLHGLQMLKSLQS 86 Query: 430 PYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 ++V ++G CE + +L E LG L+ + + K +++ H++ + M+Y+ N Sbjct: 87 EHVVTLVGYCEEDGTILT-EYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSIIN 145 Query: 490 FVH 492 ++H Sbjct: 146 YLH 148 >5CLR-A nrPDB Length = 451 Score = 36.2 bits (82), Expect = 0.043, Method: Compositional matrix adjust. Identities = 32/115 (27%), Positives = 50/115 (43%), Gaps = 19/115 (16%) Query: 471 IIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQT 530 +I + HQV K E +HRDL N++L + DFG S + K Sbjct: 182 MISVCHQV----KQFHELGLIHRDLKPGNIMLDADMQCHLVDFGSSSS-------DKEPK 230 Query: 531 HGKWPVKWY-APECI---NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 W Y APE ++ FS SD+++ + E F+ P+R +K ++V Sbjct: 231 PASWGTASYLAPELNAQEDFIAFSQVSDLFALAYSLDELFN----PFRQVKFAKV 281 >2CRH-A nrPDB Length = 138 Score = 35.4 bits (80), Expect = 0.087, Method: Compositional matrix adjust. Identities = 30/109 (27%), Positives = 46/109 (42%), Gaps = 9/109 (8%) Query: 8 DSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIE 67 D + HL ++ G + R AE L SDG +L+RQ FA+S+ + + H I Sbjct: 22 DLSVHL-WYAGPMERAGAESILAN--RSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKI- 77 Query: 68 RELNGTYAIAGGRTHASPADLCHYHSQES-----DGLVCLLKKPFNRPQ 111 G Y I + +L ++ Q S L L+ PF P+ Sbjct: 78 MTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPE 126 >5GZA-A nrPDB Length = 290 Score = 35.0 bits (79), Expect = 0.10, Method: Compositional matrix adjust. Identities = 34/133 (25%), Positives = 65/133 (48%), Gaps = 28/133 (21%) Query: 383 GTVKKGY---YQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC 439 G VKK Y +Q +KV A+ +L ++ D+ L ++++ L + ++V ++G+C Sbjct: 36 GAVKKVYLSEWQGQKV----ALSVLSSDQ----YADDFLHGLSMLRALQSSHVVTLVGVC 87 Query: 440 EAESWMLVMEMAELGP---LNKYLQQNR-------HVKDKNIIELV------HQVSMGMK 483 E ++ + V E LG L+ L Q R H + + I+ V H G++ Sbjct: 88 EEDA-VFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLAYLHSSPAGIR 146 Query: 484 YLEESNFVHRDLA 496 + +SN +H+ L+ Sbjct: 147 VMCDSNDLHKTLS 159 >4IAN-A nrPDB Length = 358 Score = 35.0 bits (79), Expect = 0.10, Method: Compositional matrix adjust. Identities = 49/202 (24%), Positives = 87/202 (43%), Gaps = 23/202 (11%) Query: 378 GSGNFGTVKKGYYQMKKVVKTVAVKILKNE--ANDPALKD-ELLAEANVMQQLDNPYIVR 434 G G F V + + + VAVKI++N LK+ E L + N D + +R Sbjct: 39 GQGVFSNVVRAR-DNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLR 97 Query: 435 MI-GICEAESWMLVMEMAELGPLNKYLQQ--NRHVKD-----KNIIELVHQVSMGMKYLE 486 + + LV E PL+ L++ ++ KD K + Q+ + +K L+ Sbjct: 98 LFRHFYHKQHLCLVFE-----PLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLK 152 Query: 487 ESNFVHRDLAARNVLL-VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 N +H D+ N+L+ ++ K+ DFG A +N ++ + APE I Sbjct: 153 RCNILHADIKPDNILVNESKTILKLCDFG--SASHVADNDITPYLVSRF---YRAPEIII 207 Query: 546 YYKFSSKSDVWSFGVLMWEAFS 567 + D+WS G ++E ++ Sbjct: 208 GKSYDYGIDMWSVGCTLYELYT 229 >5UU1-A nrPDB Length = 324 Score = 35.0 bits (79), Expect = 0.11, Method: Compositional matrix adjust. Identities = 34/133 (25%), Positives = 63/133 (47%), Gaps = 16/133 (12%) Query: 448 MEMAELG-PLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQH 506 M M LG L K QN K +++L ++ ++Y+ E+ +VH D+ A N+LL ++ Sbjct: 108 MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN 167 Query: 507 YAKI--SDFGLSKALRADENYYKAQTHGK----WPVKWYAPECINYYKFSSKSDV----- 555 ++ +D+GLS + N+ + Q + + +++ + + S +SDV Sbjct: 168 PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGY 227 Query: 556 ----WSFGVLMWE 564 W G L WE Sbjct: 228 CMLRWLCGKLPWE 240 >3EB0-A nrPDB Length = 383 Score = 34.7 bits (78), Expect = 0.12, Method: Compositional matrix adjust. Identities = 30/142 (21%), Positives = 65/142 (45%), Gaps = 9/142 (6%) Query: 456 LNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQ-HYAKISDFG 514 L +++ R + I ++Q+ + ++ HRD+ +N+L+ ++ + K+ DFG Sbjct: 128 LKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLKLCDFG 187 Query: 515 LSKALRADENYYKAQTHGKWPVKWYAPEC-INYYKFSSKSDVWSFGVLMWEAFSYGQKPY 573 +K L E A ++ + APE + +++ D+WS G + E G+ + Sbjct: 188 SAKKLIPSEPSV-AYICSRF---YRAPELMLGATEYTPSIDLWSIGCVFGELI-LGKPLF 242 Query: 574 RGMKGSEVTAMLEKGERMGCPA 595 G + + ++ + MG P Sbjct: 243 SG--ETSIDQLVRIIQIMGTPT 262 >6EWX-A nrPDB Length = 484 Score = 34.7 bits (78), Expect = 0.12, Method: Compositional matrix adjust. Identities = 14/38 (36%), Positives = 25/38 (65%) Query: 466 VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV 503 V ++ + L+ Q+ G+++L+E +HRDL N+LLV Sbjct: 207 VYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLV 244 >3QWY-A nrPDB Length = 308 Score = 34.7 bits (78), Expect = 0.12, Method: Compositional matrix adjust. Identities = 34/105 (32%), Positives = 50/105 (47%), Gaps = 13/105 (12%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVA---HGRKAHHYTIER--- 68 F+F ++REEA L + +S G +L+R S + G ++L+V G HY IER Sbjct: 43 FYFPGMSREEAHKLLGEPQVSIGTFLMRDS-SRPGEYSLTVREADEGNAVCHYLIERGEP 101 Query: 69 ELNGTYA----IAGGRTHASPADLCHYHSQ--ESDGLVCLLKKPF 107 + +GT A IA PA L H+ + L+ KKP Sbjct: 102 KEDGTAAAGVKIANQSFPDIPALLNHFKMRVLTEASLLAAYKKPI 146 >5OAT-A nrPDB Length = 411 Score = 34.3 bits (77), Expect = 0.17, Method: Compositional matrix adjust. Identities = 33/110 (30%), Positives = 46/110 (41%), Gaps = 18/110 (16%) Query: 481 GMKYLEESNFVHRDLAARNVLLVTQH----YAKISDFGLSKA-----LRADENYYKAQTH 531 G+ ++ HRDL + N+LL T ISDFG A L Y+ Sbjct: 165 GVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKG 224 Query: 532 GKWPVKWYAPE--CINYYKFS----SKSDVWSFGVLMWEAFSYGQKPYRG 575 G APE C FS SK+D+W+ G + +E F+ P+ G Sbjct: 225 GN--TALMAPEIICQKPGTFSVLNYSKADLWAVGAIAYEIFN-CHNPFYG 271 >6O6Q-A nrPDB Length = 335 Score = 34.3 bits (77), Expect = 0.18, Method: Compositional matrix adjust. Identities = 45/206 (21%), Positives = 93/206 (45%), Gaps = 22/206 (10%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL-DNPYIV 433 ++LG G + V G K+ + V +K+LK P + ++ E ++++ L D P I+ Sbjct: 47 RKLGRGKYSEVFLGIDLEKR--EKVVIKVLK-----PVKRKKIKREISILKNLVDGPNII 99 Query: 434 RMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 M+ + E +S + + ++ + D +I ++++ + Y +H Sbjct: 100 AMLDVVREPQSKTPGLIFEHINNID-FRSLYPTFTDYDIRFYMYELLKALDYSHSMGIMH 158 Query: 493 RDLAARNVLLV-TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 RD+ NV++ + ++ D+GL++ Y + ++ + PE + Y+ Sbjct: 159 RDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTE-YNVRVASRY---FKGPELLVDYRLYD 214 Query: 552 KS-DVWSFG------VLMWEAFSYGQ 570 S D+WSFG V M E F +G+ Sbjct: 215 YSLDMWSFGCMLASMVFMKEPFFHGK 240 Score = 30.0 bits (66), Expect = 3.0, Method: Compositional matrix adjust. Identities = 15/38 (39%), Positives = 25/38 (65%), Gaps = 1/38 (2%) Query: 157 LIATTAHEKMPWFHGKISREESEQIV-LIGSKTNGKFL 193 ++A+ K P+FHGK + ++ QIV ++GSK K+L Sbjct: 225 MLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYL 262 >5VE6-A nrPDB Length = 492 Score = 34.3 bits (77), Expect = 0.19, Method: Compositional matrix adjust. Identities = 13/36 (36%), Positives = 24/36 (66%) Query: 468 DKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV 503 ++ + L+ Q+ G+++L+E +HRDL N+LLV Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLV 242 >4CRL-A nrPDB Length = 406 Score = 33.9 bits (76), Expect = 0.22, Method: Compositional matrix adjust. Identities = 26/100 (26%), Positives = 48/100 (48%), Gaps = 7/100 (7%) Query: 474 LVHQVSMGMKYLEESNFVHRDLAARNVLLV----TQHYAKISDFGLSKALRADENYYKAQ 529 L++Q+ G+ YL + +HRDL N+L++ + KI+D G ++ + A Sbjct: 134 LLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPL-AD 192 Query: 530 THGKWPVKWY-APECINYYKFSSKS-DVWSFGVLMWEAFS 567 WY APE + + +K+ D+W+ G + E + Sbjct: 193 LDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT 232 >6HMD-A nrPDB Length = 365 Score = 33.5 bits (75), Expect = 0.30, Method: Compositional matrix adjust. Identities = 29/118 (24%), Positives = 53/118 (44%), Gaps = 16/118 (13%) Query: 466 VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA-KISDFGLSKALRADEN 524 + D +I ++++ + Y +HRD+ NV++ Q ++ D+GL+ E Sbjct: 144 LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA------EF 197 Query: 525 YYKAQTHGKWPVKWY--APE-CINYYKFSSKSDVWSFGVLMW------EAFSYGQKPY 573 Y+ AQ + Y PE ++Y + D+WS G ++ E F +GQ Y Sbjct: 198 YHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY 255 >4MD7-E nrPDB Length = 391 Score = 33.1 bits (74), Expect = 0.35, Method: Compositional matrix adjust. Identities = 27/118 (22%), Positives = 52/118 (44%), Gaps = 16/118 (13%) Query: 466 VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA-KISDFGLSKALRADEN 524 + D +I ++++ + Y +HRD+ NV++ +H ++ D+GL+ E Sbjct: 128 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA------EF 181 Query: 525 YYKAQTHGKWPVKWY--APE-CINYYKFSSKSDVWSFGVLMW------EAFSYGQKPY 573 Y+ Q + Y PE ++Y + D+WS G ++ E F +G Y Sbjct: 182 YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNY 239 >2LCT-A nrPDB Length = 107 Score = 32.7 bits (73), Expect = 0.52, Method: Compositional matrix adjust. Identities = 26/91 (28%), Positives = 40/91 (43%), Gaps = 4/91 (4%) Query: 6 MADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYT 65 M D + HL ++ G + R AE L SDG +L+RQ FA+S+ + + H Sbjct: 3 MQDLSVHL-WYAGPMERAGAESIL--ANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIK 59 Query: 66 IERELNGTYAIAGGRTHASPADLCHYHSQES 96 I G Y I + +L ++ Q S Sbjct: 60 I-MTAEGLYRITEKKAFRGLTELVEFYQQNS 89 >5M07-A nrPDB Length = 276 Score = 32.3 bits (72), Expect = 0.60, Method: Compositional matrix adjust. Identities = 28/133 (21%), Positives = 59/133 (44%), Gaps = 22/133 (16%) Query: 400 AVKILKNE-ANDPALKDELLAEANVMQQLDNPYIVRM--IGICEAESWMLVMEMAELGPL 456 A+K+L A D + E V +L +P+I+ + G + + W + M+ + Sbjct: 59 ALKVLSPAMAADDEFRRRFQRETEVAARLFHPHILEVHDRGEFDGQLW-IAMDYVD---- 113 Query: 457 NKYLQQNRHVKDK--------NIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA 508 + +H+ D+ ++ +V V+ + Y + +HRD+ NV+L +Q Sbjct: 114 --GIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYAHQRGLLHRDVNPANVVLTSQSAG 171 Query: 509 K----ISDFGLSK 517 ++DFG++ Sbjct: 172 DQRILLADFGIAS 184 >6C5X-D nrPDB Length = 164 Score = 32.0 bits (71), Expect = 0.75, Method: Composition-based stats. Identities = 26/79 (32%), Positives = 41/79 (51%), Gaps = 6/79 (7%) Query: 186 SKTNGKFLIR-ARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKK-FDTLWQLVEH 243 S+ G FLIR ++ N +A+ + + + RI K GK S+ K+ F L+QLVEH Sbjct: 48 SEPIGTFLIRDSKQKNCFFAISVKTARETVSIRI-KFHAGKFSLDGSKELFSCLFQLVEH 106 Query: 244 YSYKADGLLRVLTVPCQKI 262 Y ++L P +K+ Sbjct: 107 YMTSPK---KMLVSPLRKV 122 >5X18-A nrPDB Length = 295 Score = 32.0 bits (71), Expect = 0.86, Method: Compositional matrix adjust. Identities = 36/153 (23%), Positives = 68/153 (44%), Gaps = 13/153 (8%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K++G G+FG + +G + V VA+K + P L+DE + + PY Sbjct: 13 KKIGEGSFGVLFEGTNMINGV--PVAIKFEPRKTEAPQLRDEYKTYKILNGTPNIPYAYY 70 Query: 435 MIGICEAESWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 E +LV+++ LGP + L R K ++++ Q+ ++ L + ++ Sbjct: 71 F--GQEGLHNILVIDL--LGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHAHDLIY 126 Query: 493 RDLAARNVLL-----VTQHYAKISDFGLSKALR 520 RD+ N L+ + + DFG++K R Sbjct: 127 RDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYR 159 >6EII-A nrPDB Length = 352 Score = 31.6 bits (70), Expect = 1.0, Method: Compositional matrix adjust. Identities = 27/118 (22%), Positives = 52/118 (44%), Gaps = 16/118 (13%) Query: 466 VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA-KISDFGLSKALRADEN 524 + D +I ++++ + Y +HRD+ NV++ +H ++ D+GL+ E Sbjct: 151 LTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA------EF 204 Query: 525 YYKAQTHGKWPVKWY--APE-CINYYKFSSKSDVWSFGVLMW------EAFSYGQKPY 573 Y+ Q + Y PE ++Y + D+WS G ++ E F +G Y Sbjct: 205 YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNY 262 >1WA5-C nrPDB Length = 960 Score = 31.2 bits (69), Expect = 1.4, Method: Compositional matrix adjust. Identities = 26/99 (26%), Positives = 48/99 (48%), Gaps = 16/99 (16%) Query: 95 ESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQL 154 E++ L+K + + VQ T +ED+ +I E+++ TWNL IS +P+ Sbjct: 252 ETEHASVLIKVKSSIQELVQLYTTRYEDVFGPMINEFIQITWNLLTS------ISNQPKY 305 Query: 155 EKLIA-----TTAHEKMPWFHGKISREE-----SEQIVL 183 + L++ TA ++P + + E +EQI+L Sbjct: 306 DILVSKSLSFLTAVTRIPKYFEIFNNESAMNNITEQIIL 344 >4IX6-A nrPDB Length = 350 Score = 31.2 bits (69), Expect = 1.6, Method: Compositional matrix adjust. Identities = 18/42 (42%), Positives = 24/42 (57%), Gaps = 6/42 (14%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELL 418 LGSGNFGTV +G ++ + V +LKN D +ELL Sbjct: 28 LGSGNFGTVFRGVFKGDQDV------VLKNAKADVMAAEELL 63 >3LAC-A nrPDB Length = 215 Score = 30.8 bits (68), Expect = 1.7, Method: Compositional matrix adjust. Identities = 23/75 (30%), Positives = 34/75 (45%), Gaps = 4/75 (5%) Query: 10 ANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERE 69 NHL F+G + E D ++GG +L Q+ NY G ++S++ RK +E Sbjct: 143 CNHL--FYGLMHELEKHDTKMKGGFIHIPFLPEQASNYPGQPSMSLSTIRKGIELAVEVT 200 Query: 70 LNGTYAI--AGGRTH 82 I GG TH Sbjct: 201 TTVEVDIVEVGGTTH 215 >4LFI-A nrPDB Length = 374 Score = 30.8 bits (68), Expect = 2.1, Method: Compositional matrix adjust. Identities = 28/137 (20%), Positives = 60/137 (43%), Gaps = 20/137 (14%) Query: 481 GMKYLEESNFVHRDLAARNVLLVTQHYA-KISDFGLSKALRADENYYKAQTHGKWPVKWY 539 + Y +HRD+ NV++ ++ ++ D+GL++ + Y + ++ + Sbjct: 184 ALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEY-NVRVASRF---FK 239 Query: 540 APEC-INYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGER-------- 590 PE ++Y + D+WSFG ++ + + ++P+ G+ T L K + Sbjct: 240 GPELLVDYRMYDYSLDLWSFGTML-ASMIFKREPF--FHGTSNTDQLVKIVKVLGTSDFE 296 Query: 591 ---MGCPAGCPREMYDL 604 + PRE YD+ Sbjct: 297 KYLLKYEITLPREFYDM 313 >4WEP-A nrPDB Length = 297 Score = 30.4 bits (67), Expect = 2.2, Method: Compositional matrix adjust. Identities = 15/37 (40%), Positives = 23/37 (62%), Gaps = 1/37 (2%) Query: 96 SDGLVCLLK-KPFNRPQGVQPKTGPFEDLKENLIREY 131 +DG V L + + PQGVQP P ++E+++REY Sbjct: 198 TDGPVAALGLQTLSDPQGVQPIYAPAPVVRESVLREY 234 >6J6I-B nrPDB Length = 351 Score = 30.4 bits (67), Expect = 2.3, Method: Compositional matrix adjust. Identities = 38/171 (22%), Positives = 75/171 (43%), Gaps = 25/171 (14%) Query: 404 LKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNK---- 458 +K ND L + +N +Q ++G C E +LV E AE G +N+ Sbjct: 101 VKEVYNDIVLSARMSNHSNFLQ---------LLGCCLEFPFPVLVFEFAEHGAMNQRGGV 151 Query: 459 YLQQNRHVKDKNI-IELVHQVSMGMKYLEESN---FVHRDLAARNVLLVTQHYAKISDFG 514 + + ++ +++ +++ + YL + +HRD+ +V L AK+SD Sbjct: 152 IVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLDKNWTAKLSDLS 211 Query: 515 LSKALRADENYYKAQTHGKWPVKWYAPECINYYK---FSSKSDVWSFGVLM 562 S +L K++ +W + + Y+K + +DV+SFG+ + Sbjct: 212 FSISLPEG----KSRIEAEWVLGTFGYIDPLYHKTCFVTEYTDVYSFGICL 258 >6C7Y-B nrPDB Length = 117 Score = 29.6 bits (65), Expect = 3.8, Method: Composition-based stats. Identities = 25/78 (32%), Positives = 40/78 (51%), Gaps = 6/78 (7%) Query: 186 SKTNGKFLIR-ARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKK-FDTLWQLVEH 243 S+ G FLIR + N +A+ + RI+ +TG+ S+ K+ FD L++L+EH Sbjct: 44 SEPEGTFLIRDSTQKNCFFAISVKTATGPTSIRINF-QTGRFSLDGSKETFDCLFKLLEH 102 Query: 244 YSYKADGLLRVLTVPCQK 261 Y +VL P +K Sbjct: 103 YLSSPR---KVLVTPLRK 117 >5XVU-A nrPDB Length = 332 Score = 29.6 bits (65), Expect = 3.8, Method: Compositional matrix adjust. Identities = 23/105 (21%), Positives = 41/105 (39%), Gaps = 22/105 (20%) Query: 468 DKNIIELVHQVSMGMKYLEESNFVHRDLAARNVL---------LVTQHYAKISDFGLSKA 518 DK+I ++Q+ + Y +HRD+ N++ L++ A+ G Sbjct: 124 DKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYN 183 Query: 519 LRADENYYKAQTHGKWPVKWYAPE-CINYYKFSSKSDVWSFGVLM 562 +R YYK PE I+ + D+WS G ++ Sbjct: 184 VRVASRYYK------------GPELLIDLQLYDYSLDIWSLGCML 216 >5X1R-A nrPDB Length = 302 Score = 29.6 bits (65), Expect = 4.3, Method: Compositional matrix adjust. Identities = 29/162 (17%), Positives = 67/162 (41%), Gaps = 23/162 (14%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVK-------ILKNEANDPALKDE------------L 417 +G G FG V + Y ++ +T+A+K +N+ L+ E Sbjct: 29 IGEGGFGIVYRAYDH--QLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQAGLNSF 86 Query: 418 LAEANVMQQLDNPYIVRMIGICE--AESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELV 475 + EA ++ + +P ++ ++ E ++M + N QQ + + I L+ Sbjct: 87 IQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQPEKIDEAWIRRLL 146 Query: 476 HQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSK 517 + + + + ++HRD++ N+ + + DFG ++ Sbjct: 147 PPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSAR 188 >2Y6E-A nrPDB Length = 367 Score = 29.3 bits (64), Expect = 6.1, Method: Compositional matrix adjust. Identities = 29/115 (25%), Positives = 45/115 (39%), Gaps = 27/115 (23%) Query: 538 WYAPECINYYKFSSKSDVWSFG---VLMWEAFSYG-----------QKPYRGMKGSEVTA 583 WY P C + + + K D+WS V+ + FSY + P RG+ SE Sbjct: 232 WYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFV- 290 Query: 584 MLEKGERMGCPAGCPREMYDLMNLCWTY---DVENRPGFAAVELRLRNYYYDVVN 635 C +YDL+ + Y V + +A +L + YY+D N Sbjct: 291 ---------CNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDSN 336 >5THG-A nrPDB Length = 304 Score = 28.9 bits (63), Expect = 6.6, Method: Compositional matrix adjust. Identities = 26/84 (30%), Positives = 38/84 (45%), Gaps = 12/84 (14%) Query: 121 EDLKENLIREYV----KQTWNLQGQ---ALEQAIISQKPQLEKLIATTAHEKMPWFHGKI 173 E LKEN I+E V K W L + A + I ++P + K I + W G Sbjct: 122 EHLKENGIKELVRIKAKMNWGLNDELKKAFPENISKERPLINKNIPN-----LKWLAGFT 176 Query: 174 SREESEQIVLIGSKTNGKFLIRAR 197 S E + + L S+ +GK +R R Sbjct: 177 SGEGTFYVHLAKSEASGKVYVRLR 200 >3R2T-A nrPDB Length = 249 Score = 28.9 bits (63), Expect = 8.1, Method: Compositional matrix adjust. Identities = 20/47 (42%), Positives = 24/47 (51%), Gaps = 6/47 (12%) Query: 499 NVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 NVLL Q K F L K DEN YK +THG V + PE ++ Sbjct: 88 NVLLFNQQNQKFQVFLLGK----DENKYKEKTHG-LDV-FAVPELVD 128 >2RSV-A nrPDB Length = 403 Score = 28.5 bits (62), Expect = 9.2, Method: Compositional matrix adjust. Identities = 14/50 (28%), Positives = 31/50 (62%), Gaps = 2/50 (4%) Query: 469 KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKI--SDFGLS 516 K +++L ++ ++Y+ E +VH D+ A N+LL ++ ++ D+GL+ Sbjct: 159 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 208 >2LAV-A nrPDB Length = 361 Score = 28.5 bits (62), Expect = 9.4, Method: Compositional matrix adjust. Identities = 14/50 (28%), Positives = 31/50 (62%), Gaps = 2/50 (4%) Query: 469 KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKI--SDFGLS 516 K +++L ++ ++Y+ E +VH D+ A N+LL ++ ++ D+GL+ Sbjct: 152 KTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4FL3-A nrPDB 944 0.0 2OZO-A nrPDB 729 0.0 5C26-A nrPDB 434 e-122 1A81-A nrPDB 376 e-104 4XEY-B nrPDB 365 e-101 2FO0-A nrPDB 362 e-100 4XI2-A nrPDB 356 2e-98 4XZ1-A nrPDB 354 9e-98 1U59-A nrPDB 344 7e-95 4CSV-A nrPDB 331 5e-91 2XYN-A nrPDB 313 2e-85 2PL0-A nrPDB 311 4e-85 3DKO-A nrPDB 310 1e-84 2J0K-A nrPDB 310 1e-84 4P5Q-A nrPDB 310 1e-84 4EBW-A nrPDB 310 2e-84 6NPU-A nrPDB 309 2e-84 2Y6O-A nrPDB 308 6e-84 2R2P-A nrPDB 307 1e-83 2H8H-A nrPDB 306 1e-83 6F3F-A nrPDB 306 2e-83 2DQ7-X nrPDB 306 3e-83 1JPA-A nrPDB 306 3e-83 5SYS-A nrPDB 304 1e-82 5MJB-A nrPDB 303 2e-82 4PDO-A nrPDB 301 6e-82 4H1J-A nrPDB 301 7e-82 3KUL-B nrPDB 298 5e-81 2HK5-A nrPDB 298 5e-81 5L6P-A nrPDB 296 2e-80 4E93-A nrPDB 295 4e-80 3TT0-A nrPDB 295 4e-80 2VWV-A nrPDB 294 9e-80 3GQL-A nrPDB 293 1e-79 3A4O-X nrPDB 293 2e-79 1AD5-A nrPDB 293 2e-79 4AT3-A nrPDB 293 2e-79 2PSQ-A nrPDB 293 2e-79 4HZS-A nrPDB 292 3e-79 6GQK-A nrPDB 292 4e-79 3BBT-B nrPDB 291 8e-79 5U6B-A nrPDB 291 8e-79 1U54-B nrPDB 290 1e-78 5AMN-A nrPDB 290 2e-78 4K33-A nrPDB 290 2e-78 5A46-A nrPDB 289 2e-78 3V5Q-A nrPDB 289 2e-78 4XCU-A nrPDB 288 5e-78 5EG3-A nrPDB 286 1e-77 3PP0-A nrPDB 286 2e-77 5GNK-A nrPDB 286 3e-77 3CJF-A nrPDB 285 5e-77 3LZB-A nrPDB 284 5e-77 4OLI-A nrPDB 284 8e-77 5U6C-A nrPDB 283 2e-76 1K9A-A nrPDB 283 2e-76 3QUP-A nrPDB 283 2e-76 1BYG-A nrPDB 282 3e-76 5FM2-A nrPDB 282 3e-76 1FVR-A nrPDB 282 3e-76 5H2U-A nrPDB 281 6e-76 3QGY-A nrPDB 280 1e-75 3ZBF-A nrPDB 279 2e-75 6DBM-A nrPDB 279 2e-75 2OGV-A nrPDB 279 3e-75 1LUF-A nrPDB 279 3e-75 3C1X-A nrPDB 278 5e-75 5HLW-A nrPDB 278 7e-75 4LRM-A nrPDB 278 8e-75 4E20-A nrPDB 277 9e-75 5KMM-A nrPDB 277 1e-74 4Y93-A nrPDB 277 1e-74 3BEA-A nrPDB 277 1e-74 6E4F-A nrPDB 277 1e-74 4XLV-A nrPDB 277 1e-74 3SXS-A nrPDB 276 1e-74 3KRL-A nrPDB 276 2e-74 4R7H-A nrPDB 275 5e-74 3G0E-A nrPDB 274 6e-74 3I81-A nrPDB 274 6e-74 6DBN-A nrPDB 273 1e-73 6FER-A nrPDB 273 3e-73 4XUF-A nrPDB 272 3e-73 6BSD-A nrPDB 272 3e-73 5X02-A nrPDB 272 4e-73 6FEX-A nrPDB 271 5e-73 5WNO-A nrPDB 271 7e-73 5GRN-A nrPDB 271 8e-73 5D9K-A nrPDB 270 1e-72 2W1I-A nrPDB 270 1e-72 3IO7-A nrPDB 269 3e-72 4UY9-A nrPDB 267 1e-71 3DTC-A nrPDB 267 1e-71 3HZT-A nrPDB 266 2e-71 4MVF-A nrPDB 266 3e-71 2QNJ-A nrPDB 265 5e-71 3PLS-A nrPDB 265 5e-71 3ZZW-A nrPDB 265 5e-71 3PPZ-A nrPDB 264 6e-71 3AOX-A nrPDB 264 7e-71 3DXN-A nrPDB 264 1e-70 5KZ7-A nrPDB 263 1e-70 3Q5I-A nrPDB 263 1e-70 2Z7Q-A nrPDB 263 2e-70 5ES1-A nrPDB 263 2e-70 3LIJ-A nrPDB 261 6e-70 3NCG-A nrPDB 260 1e-69 5IG1-A nrPDB 260 1e-69 5JN2-A nrPDB 260 1e-69 4UYA-A nrPDB 259 4e-69 3DFA-A nrPDB 258 4e-69 6FDY-U nrPDB 258 4e-69 4HVI-A nrPDB 258 5e-69 5VO2-A nrPDB 258 5e-69 4GS6-A nrPDB 257 1e-68 5YKS-A nrPDB 257 1e-68 3MA6-A nrPDB 256 2e-68 2HAK-A nrPDB 256 3e-68 5X5O-A nrPDB 254 7e-68 5EZV-A nrPDB 254 1e-67 2BDW-A nrPDB 253 2e-67 6C9D-A nrPDB 252 3e-67 4CFF-A nrPDB 252 3e-67 4CZT-A nrPDB 252 4e-67 4L42-A nrPDB 251 5e-67 3KK8-A nrPDB 251 6e-67 5FG8-A nrPDB 251 1e-66 3COM-A nrPDB 251 1e-66 4FIE-A nrPDB 250 2e-66 2YZA-A nrPDB 249 2e-66 3MN3-A nrPDB 249 2e-66 4QMW-A nrPDB 249 3e-66 4D28-A nrPDB 249 4e-66 5X3F-B nrPDB 249 4e-66 4RED-A nrPDB 248 4e-66 4REW-A nrPDB 248 5e-66 4RLP-A nrPDB 248 6e-66 2V7O-A nrPDB 248 6e-66 4WB7-A nrPDB 248 8e-66 3LMG-A nrPDB 248 8e-66 2VN9-A nrPDB 248 9e-66 3H4J-B nrPDB 247 1e-65 4JDH-A nrPDB 246 2e-65 4CFH-A nrPDB 246 2e-65 5N23-A nrPDB 246 3e-65 3KN6-A nrPDB 246 3e-65 5U6Y-A nrPDB 245 4e-65 2VZ6-A nrPDB 245 5e-65 4RGJ-A nrPDB 244 7e-65 5KCV-A nrPDB 244 8e-65 4YNZ-A nrPDB 244 9e-65 5HI2-A nrPDB 244 1e-64 2JDO-A nrPDB 244 1e-64 5FET-A nrPDB 243 1e-64 4CQG-A nrPDB 242 2e-64 3HDN-A nrPDB 242 3e-64 5XZW-A nrPDB 242 3e-64 3BHH-A nrPDB 242 4e-64 2JC6-A nrPDB 242 4e-64 1FOT-A nrPDB 242 5e-64 4LG4-A nrPDB 241 5e-64 2XIK-A nrPDB 241 7e-64 3OMV-A nrPDB 241 8e-64 4YZB-A nrPDB 241 9e-64 2WQN-A nrPDB 241 9e-64 4D2V-A nrPDB 240 1e-63 4FZF-B nrPDB 240 1e-63 6AO5-A nrPDB 240 1e-63 3DB8-A nrPDB 240 2e-63 3DAK-A nrPDB 240 2e-63 4FG9-A nrPDB 239 2e-63 3MV5-A nrPDB 239 3e-63 5HIE-A nrPDB 239 3e-63 4RA4-A nrPDB 239 3e-63 4WNO-A nrPDB 239 4e-63 3SOA-A nrPDB 238 4e-63 2JAM-A nrPDB 238 5e-63 4B6L-A nrPDB 238 6e-63 4NEU-A nrPDB 237 1e-62 4C0T-A nrPDB 237 1e-62 4I6B-A nrPDB 237 1e-62 6QAU-A nrPDB 235 4e-62 4APC-A nrPDB 235 5e-62 5DBX-A nrPDB 234 6e-62 5DYK-A nrPDB 234 7e-62 5F9E-A nrPDB 234 7e-62 4UZD-A nrPDB 234 7e-62 3D2K-A nrPDB 234 7e-62 4PDS-A nrPDB 234 8e-62 4XBR-A nrPDB 234 9e-62 3TXO-A nrPDB 234 1e-61 2OU7-A nrPDB 234 1e-61 4J52-A nrPDB 234 1e-61 3IS5-A nrPDB 233 2e-61 2Q0N-A nrPDB 233 2e-61 2XNP-A nrPDB 232 3e-61 2YCR-A nrPDB 232 3e-61 4NIF-A nrPDB 231 6e-61 2J90-A nrPDB 231 6e-61 4BBM-A nrPDB 231 6e-61 4JXF-A nrPDB 231 7e-61 6HXF-B nrPDB 231 7e-61 4YFF-A nrPDB 231 7e-61 3NIZ-A nrPDB 231 9e-61 3I6U-A nrPDB 231 1e-60 4JG6-A nrPDB 230 1e-60 2UV2-A nrPDB 230 1e-60 6FD3-A nrPDB 229 2e-60 4AW2-A nrPDB 229 2e-60 6BXI-A nrPDB 229 3e-60 3TKU-A nrPDB 229 3e-60 2BPM-A nrPDB 228 4e-60 1VZO-A nrPDB 228 5e-60 2W4O-A nrPDB 228 5e-60 3PFQ-A nrPDB 227 8e-60 3Q53-A nrPDB 227 9e-60 2X4F-A nrPDB 227 1e-59 6BDL-A nrPDB 226 2e-59 5JZN-A nrPDB 226 2e-59 2I0E-A nrPDB 226 2e-59 4AGU-A nrPDB 226 2e-59 6CMJ-A nrPDB 226 3e-59 2Y7J-A nrPDB 226 3e-59 3GUB-A nrPDB 225 6e-59 6E9W-A nrPDB 224 8e-59 1PHK-A nrPDB 224 1e-58 3F3Z-A nrPDB 223 1e-58 2YAB-A nrPDB 223 2e-58 2F57-A nrPDB 222 3e-58 3A8W-A nrPDB 222 3e-58 1G3N-A nrPDB 222 5e-58 4FR4-A nrPDB 221 5e-58 5HVK-A nrPDB 221 8e-58 4TPT-A nrPDB 221 9e-58 5WAX-A nrPDB 220 1e-57 5LOH-A nrPDB 220 2e-57 5YV8-A nrPDB 220 2e-57 1ZWS-A nrPDB 219 3e-57 3TAC-A nrPDB 219 3e-57 2A27-A nrPDB 219 3e-57 3UC3-A nrPDB 218 4e-57 4F0G-A nrPDB 218 5e-57 6GU6-A nrPDB 218 6e-57 4KS7-A nrPDB 218 7e-57 4AU8-A nrPDB 217 8e-57 3FI2-A nrPDB 217 9e-57 1JNK-A nrPDB 217 9e-57 1KOB-A nrPDB 217 1e-56 2XS0-A nrPDB 217 1e-56 5AWM-A nrPDB 216 2e-56 5EFQ-A nrPDB 216 2e-56 4B8L-A nrPDB 216 2e-56 5WNL-A nrPDB 215 5e-56 5Z33-A nrPDB 215 5e-56 3UTO-A nrPDB 215 6e-56 3ORZ-A nrPDB 215 6e-56 1V0B-A nrPDB 215 6e-56 6E2O-A nrPDB 214 8e-56 3ZUT-A nrPDB 214 1e-55 5D7A-A nrPDB 213 1e-55 4KRC-A nrPDB 213 1e-55 3UDB-A nrPDB 213 1e-55 1KOA-A nrPDB 213 2e-55 4AF3-A nrPDB 213 2e-55 6ED6-A nrPDB 213 2e-55 2HW6-A nrPDB 212 3e-55 3E7O-A nrPDB 212 3e-55 4AN9-A nrPDB 212 3e-55 3C51-A nrPDB 212 3e-55 4NST-A nrPDB 212 4e-55 3ZDU-A nrPDB 212 4e-55 1U5R-A nrPDB 212 5e-55 2VD5-A nrPDB 211 9e-55 2GCD-A nrPDB 211 1e-54 6DTL-A nrPDB 211 1e-54 3LM0-A nrPDB 210 2e-54 4BGQ-A nrPDB 210 2e-54 5UUU-A nrPDB 210 2e-54 5NGU-A nrPDB 210 2e-54 3PVW-A nrPDB 210 2e-54 3VHK-A nrPDB 209 4e-54 4QTB-A nrPDB 208 6e-54 3ORP-A nrPDB 208 6e-54 4TNB-A nrPDB 207 9e-54 4EWQ-A nrPDB 207 9e-54 2BRG-A nrPDB 207 1e-53 3HKO-A nrPDB 207 1e-53 5UIU-A nrPDB 207 2e-53 1CM8-A nrPDB 206 2e-53 5J5T-A nrPDB 206 2e-53 3GC0-A nrPDB 206 3e-53 3NYO-A nrPDB 206 4e-53 3FXW-A nrPDB 205 4e-53 1UA2-A nrPDB 205 4e-53 4IC8-A nrPDB 205 5e-53 5TOS-A nrPDB 205 5e-53 3HNG-A nrPDB 205 5e-53 6CCF-A nrPDB 204 7e-53 3OZ6-A nrPDB 204 7e-53 4EQM-A nrPDB 204 8e-53 4ZSG-A nrPDB 204 1e-52 6CQF-A nrPDB 204 1e-52 2WTK-C nrPDB 204 1e-52 4MYG-A nrPDB 204 1e-52 2W96-B nrPDB 202 3e-52 4LQP-A nrPDB 202 3e-52 4QNY-A nrPDB 202 4e-52 4BTF-A nrPDB 201 6e-52 3VN9-A nrPDB 201 6e-52 1NY3-A nrPDB 201 7e-52 3KA0-A nrPDB 201 9e-52 3FME-A nrPDB 201 1e-51 2OZA-A nrPDB 201 1e-51 4O2Z-A nrPDB 201 1e-51 4CRS-A nrPDB 200 2e-51 6CKI-A nrPDB 200 2e-51 3REP-A nrPDB 200 2e-51 2F9G-A nrPDB 200 2e-51 4PWN-A nrPDB 199 3e-51 4M69-B nrPDB 199 3e-51 4OTD-A nrPDB 199 3e-51 2A1A-B nrPDB 199 3e-51 3OHT-A nrPDB 199 4e-51 4MWI-A nrPDB 198 5e-51 3QA8-A nrPDB 198 5e-51 5KKR-C nrPDB 198 5e-51 6J5U-C nrPDB 198 6e-51 5B2L-A nrPDB 198 7e-51 3GC9-A nrPDB 198 7e-51 3MIA-A nrPDB 197 8e-51 4KIK-B nrPDB 197 1e-50 4IDT-A nrPDB 197 1e-50 3EQC-A nrPDB 197 1e-50 3ALO-A nrPDB 197 1e-50 4YHJ-A nrPDB 196 2e-50 5O0Y-A nrPDB 196 3e-50 6GVJ-A nrPDB 195 5e-50 3UIU-A nrPDB 195 5e-50 1S9I-A nrPDB 195 5e-50 3DLS-A nrPDB 195 5e-50 5G6V-A nrPDB 195 6e-50 3HMP-A nrPDB 195 7e-50 5TQX-A nrPDB 194 8e-50 1ZXE-A nrPDB 193 2e-49 5AP3-A nrPDB 193 2e-49 2Y4I-B nrPDB 193 2e-49 4M7I-A nrPDB 193 2e-49 2ZMD-A nrPDB 193 2e-49 4U41-A nrPDB 193 2e-49 5LPZ-A nrPDB 192 3e-49 6CTH-A nrPDB 192 4e-49 5LPV-A nrPDB 192 4e-49 4X3F-A nrPDB 190 1e-48 4OW8-A nrPDB 190 1e-48 4RT7-A nrPDB 190 1e-48 5AR8-A nrPDB 190 1e-48 6B2Q-A nrPDB 190 1e-48 3N9X-A nrPDB 190 2e-48 3NIE-A nrPDB 188 7e-48 2I6L-A nrPDB 187 8e-48 2QKW-B nrPDB 187 2e-47 3MDY-A nrPDB 186 2e-47 2RIO-A nrPDB 185 6e-47 4E7W-A nrPDB 184 1e-46 5AIR-A nrPDB 184 1e-46 5VD3-A nrPDB 184 1e-46 4H1O-A nrPDB 184 1e-46 4M66-A nrPDB 183 2e-46 5USZ-A nrPDB 183 2e-46 1TKI-A nrPDB 182 4e-46 3RP9-A nrPDB 182 4e-46 4X7Q-B nrPDB 182 4e-46 3Q4U-A nrPDB 182 5e-46 3BGP-A nrPDB 180 1e-45 4G3E-A nrPDB 180 1e-45 4RC3-A nrPDB 179 3e-45 5XD6-A nrPDB 179 3e-45 5TUR-A nrPDB 178 5e-45 1PY5-A nrPDB 178 6e-45 3PG1-A nrPDB 178 8e-45 4C59-A nrPDB 177 1e-44 5Y86-A nrPDB 177 1e-44 2BUJ-A nrPDB 177 1e-44 4L00-A nrPDB 177 1e-44 4JLC-A nrPDB 177 1e-44 3UIM-A nrPDB 176 3e-44 2WO6-A nrPDB 176 3e-44 5VDK-A nrPDB 176 3e-44 4EUU-A nrPDB 175 4e-44 3M42-A nrPDB 175 6e-44 4EUT-A nrPDB 174 9e-44 6O8B-A nrPDB 174 1e-43 5ZTN-A nrPDB 174 1e-43 6NT9-A nrPDB 174 1e-43 3MY0-A nrPDB 173 2e-43 5E8V-A nrPDB 172 6e-43 4TN6-A nrPDB 171 1e-42 3E3P-A nrPDB 171 1e-42 5X8I-B nrPDB 170 1e-42 6BFN-A nrPDB 170 2e-42 3G2F-A nrPDB 170 2e-42 5FQD-C nrPDB 167 1e-41 2H34-A nrPDB 167 1e-41 4PL5-B nrPDB 166 2e-41 2B3O-A nrPDB 166 2e-41 3PS5-A nrPDB 165 7e-41 6FYV-A nrPDB 164 9e-41 3SV0-A nrPDB 164 1e-40 6HV0-A nrPDB 164 1e-40 5TE0-A nrPDB 163 2e-40 3SOC-A nrPDB 162 4e-40 5C01-A nrPDB 162 4e-40 4WOV-A nrPDB 160 2e-39 4XHH-A nrPDB 157 1e-38 5CEK-A nrPDB 152 5e-37 3QD2-B nrPDB 150 2e-36 5J0A-A nrPDB 150 2e-36 2LQW-A nrPDB 150 2e-36 2QLU-A nrPDB 149 4e-36 5UNP-A nrPDB 149 4e-36 4XHL-A nrPDB 147 1e-35 5L2Q-C nrPDB 138 6e-33 6AMW-A nrPDB 133 2e-31 2ABL-A nrPDB 128 8e-30 3T04-A nrPDB 127 2e-29 4M4Z-A nrPDB 124 1e-28 5U06-A nrPDB 118 7e-27 2AUG-A nrPDB 113 2e-25 1KA6-A nrPDB 112 5e-25 6CMQ-A nrPDB 110 2e-24 2EKX-A nrPDB 108 1e-23 1GRI-A nrPDB 107 2e-23 1NRV-A nrPDB 106 3e-23 2EOB-A nrPDB 102 5e-22 5M6U-B nrPDB 102 6e-22 2PLE-A nrPDB 101 8e-22 1M27-A nrPDB 100 3e-21 2HDV-A nrPDB 99 4e-21 2CS0-A nrPDB 95 8e-20 1RPY-A nrPDB 94 2e-19 1MIL-A nrPDB 83 3e-16 Sequences not found previously or not previously below threshold: 5O2B-A nrPDB 201 1e-51 5O2C-A nrPDB 199 2e-51 4Y83-A nrPDB 172 3e-43 3EB0-A nrPDB 164 2e-40 5VC6-A nrPDB 161 1e-39 5IKW-A nrPDB 160 2e-39 4CRL-A nrPDB 155 7e-38 6DC0-A nrPDB 153 3e-37 6O6Q-A nrPDB 152 4e-37 4IAN-A nrPDB 145 4e-35 3RAW-A nrPDB 144 1e-34 2WTK-B nrPDB 140 1e-33 5XVU-A nrPDB 140 2e-33 3LLT-A nrPDB 138 5e-33 2CMW-A nrPDB 137 2e-32 2PVN-A nrPDB 136 3e-32 1CSN-A nrPDB 135 8e-32 4MD7-E nrPDB 133 2e-31 2C47-A nrPDB 132 6e-31 6EII-A nrPDB 132 7e-31 4NT4-A nrPDB 131 8e-31 4BTK-A nrPDB 131 1e-30 2PMN-X nrPDB 131 1e-30 2CHL-A nrPDB 130 2e-30 4NFN-A nrPDB 129 3e-30 5X18-A nrPDB 127 1e-29 6HMD-A nrPDB 125 8e-29 2JD5-A nrPDB 124 1e-28 4F9B-A nrPDB 120 2e-27 2X7G-A nrPDB 120 2e-27 4WUA-A nrPDB 119 4e-27 4LFI-A nrPDB 118 5e-27 5OAT-A nrPDB 115 7e-26 4L68-A nrPDB 113 2e-25 5X1R-A nrPDB 113 3e-25 4I94-A nrPDB 112 5e-25 6EQI-C nrPDB 110 1e-24 6J6I-B nrPDB 107 2e-23 5M07-A nrPDB 106 3e-23 5UV4-A nrPDB 105 4e-23 2PZI-A nrPDB 104 1e-22 4Y12-A nrPDB 103 2e-22 2EYZ-A nrPDB 94 1e-19 4JRN-A nrPDB 88 1e-17 5CLR-A nrPDB 87 2e-17 6EAS-A nrPDB 87 3e-17 5UU1-A nrPDB 82 9e-16 2RSV-A nrPDB 76 4e-14 2LAV-A nrPDB 76 4e-14 5GZ9-A nrPDB 74 2e-13 4IX6-A nrPDB 74 2e-13 2CRH-A nrPDB 73 3e-13 2KK6-A nrPDB 73 3e-13 5GZA-A nrPDB 73 4e-13 2JII-A nrPDB 73 4e-13 4O1O-A nrPDB 72 6e-13 2LCT-A nrPDB 72 8e-13 6BHC-A nrPDB 69 5e-12 5DMZ-A nrPDB 67 3e-11 >4FL3-A nrPDB Length = 635 Score = 944 bits (2440), Expect = 0.0, Method: Composition-based stats. Identities = 633/635 (99%), Positives = 635/635 (100%) Query: 1 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 60 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK Sbjct: 1 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 60 Query: 61 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF 120 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF Sbjct: 61 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF 120 Query: 121 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ 180 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ Sbjct: 121 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ 180 Query: 181 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL 240 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL Sbjct: 181 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL 240 Query: 241 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK 300 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK Sbjct: 241 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK 300 Query: 301 PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP 360 PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEV+ESP+ADPEEIRP Sbjct: 301 PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVFESPFADPEEIRP 360 Query: 361 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 420 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE Sbjct: 361 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 420 Query: 421 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM 480 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM Sbjct: 421 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM 480 Query: 481 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA Sbjct: 481 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540 Query: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE Sbjct: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600 Query: 601 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN Sbjct: 601 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 >2OZO-A nrPDB Length = 613 Score = 729 bits (1881), Expect = 0.0, Method: Composition-based stats. Identities = 338/631 (53%), Positives = 450/631 (71%), Gaps = 30/631 (4%) Query: 6 MADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYT 65 M D A HLPFF+G+I+R EAE++L GM+DGL+LLRQ LGG+ LS+ H + HH+ Sbjct: 1 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP 60 Query: 66 IERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKE 125 IER+LNGTYAIAGG+ H PA+LC ++S++ DGL C L+KP NRP G++P+ G F+ L++ Sbjct: 61 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD 120 Query: 126 NLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIG 185 ++R+YV+QTW L+G+ALEQAIISQ PQ+EKLIATTAHE+MPW+H ++REE+E+ + G Sbjct: 121 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG 180 Query: 186 SKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYS 245 ++T+GKFL+R R G+YAL L++ V HY I +DK GK IPEG KFDTLWQLVE+ Sbjct: 181 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK 240 Query: 246 YKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRK 305 KADGL+ L C N + P LP +HP+T + Sbjct: 241 LKADGLIYCLKEACPNSSAS-NASGAAAPTLP-AHPSTLT-------------------- 278 Query: 306 SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYL 365 R+ T++ + Y PE A + P+ +PMDT V+ESP++DPEE++ K+++L Sbjct: 279 ----HPQRRIDTLNSDGYTPEPARITSPDKPR--PMPMDTSVFESPFSDPEELKDKKLFL 332 Query: 366 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 425 R L + D ELG GNFG+V++G Y+M+K VA+K+LK + + A +E++ EA +M Sbjct: 333 KRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QGTEKADTEEMMREAQIMH 391 Query: 426 QLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQ-QNRHVKDKNIIELVHQVSMGMKY 484 QLDNPYIVR+IG+C+AE+ MLVMEMA GPL+K+L + + N+ EL+HQVSMGMKY Sbjct: 392 QLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKY 451 Query: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 LEE NFVHR+LAARNVLLV +HYAKISDFGLSKAL AD++YY A++ GKWP+KWYAPECI Sbjct: 452 LEEKNFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI 511 Query: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDL 604 N+ KFSS+SDVWS+GV MWEA SYGQKPY+ MKG EV A +E+G+RM CP CP E+Y L Sbjct: 512 NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYAL 571 Query: 605 MNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 M+ CW Y E+RP F VE R+R YY + + Sbjct: 572 MSDCWIYKWEDRPDFLTVEQRMRACYYSLAS 602 >5C26-A nrPDB Length = 299 Score = 434 bits (1117), Expect = e-122, Method: Composition-based stats. Identities = 293/293 (100%), Positives = 293/293 (100%) Query: 343 MDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVK 402 MDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVK Sbjct: 1 MDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVK 60 Query: 403 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQ 462 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQ Sbjct: 61 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQ 120 Query: 463 NRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRAD 522 NRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRAD Sbjct: 121 NRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRAD 180 Query: 523 ENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVT 582 ENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVT Sbjct: 181 ENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVT 240 Query: 583 AMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 AMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN Sbjct: 241 AMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 293 >1A81-A nrPDB Length = 254 Score = 376 bits (965), Expect = e-104, Method: Composition-based stats. Identities = 254/254 (100%), Positives = 254/254 (100%) Query: 9 SANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIER 68 SANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIER Sbjct: 1 SANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIER 60 Query: 69 ELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLI 128 ELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLI Sbjct: 61 ELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLI 120 Query: 129 REYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKT 188 REYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKT Sbjct: 121 REYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKT 180 Query: 189 NGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKA 248 NGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKA Sbjct: 181 NGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKA 240 Query: 249 DGLLRVLTVPCQKI 262 DGLLRVLTVPCQKI Sbjct: 241 DGLLRVLTVPCQKI 254 Score = 91.2 bits (225), Expect = 1e-18, Method: Composition-based stats. Identities = 36/128 (28%), Positives = 64/128 (50%), Gaps = 5/128 (3%) Query: 166 MPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDKTG 224 +P+F G I+REE+E ++ G ++G +L+R N G +AL + H K HY I+++ G Sbjct: 5 LPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNG 64 Query: 225 KLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKI-GTQGNVNFGGRPQ---LPGSH 280 +I G+ + L ++S ++DGL+ +L P + G Q + + Sbjct: 65 TYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYV 124 Query: 281 PATWSAGG 288 TW+ G Sbjct: 125 KQTWNLQG 132 >4XEY-B nrPDB Length = 408 Score = 365 bits (936), Expect = e-101, Method: Composition-based stats. Identities = 148/481 (30%), Positives = 224/481 (46%), Gaps = 100/481 (20%) Query: 157 LIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDN-NGSYALCLLHEGKVLH 215 + + + EK W+HG +SR +E L+ S NG FL+R ++ G ++ L +EG+V H Sbjct: 1 MASVNSLEKHSWYHGPVSRNAAE--YLLSSGINGSFLVRESESSPGQRSISLRYEGRVYH 58 Query: 216 YRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQ 275 YRI+ GKL F + Sbjct: 59 YRINTASDGKL------------------------------------YVSSESRFNTLAE 82 Query: 276 LPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKG 335 L H + A G+I+ + +P P K + P W Sbjct: 83 LV--HHHSTVADGLIT---TLHYPAPKRNKPT------------VYGVSPNYDKW----- 120 Query: 336 PQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKV 395 ++R +T++ K LG G +G V +G + KK Sbjct: 121 ----------------------------EMERTDITMKHK-LGGGQYGEVYEGVW--KKY 149 Query: 396 VKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAES-WMLVMEMAELG 454 TVAVK LK D +E L EA VM+++ +P +V+++G+C E + ++ E G Sbjct: 150 SLTVAVKTLK---EDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYG 206 Query: 455 PLNKYLQQ--NRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISD 512 L YL++ + V ++ + Q+S M+YLE+ NF+HRDLAARN L+ H K++D Sbjct: 207 NLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVAD 266 Query: 513 FGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKP 572 FGLS+ + D Y A K+P+KW APE + Y KFS KSDVW+FGVL+WE +YG P Sbjct: 267 FGLSRLMTGD--TYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSP 324 Query: 573 YRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYD 632 Y G+ S+V +LEK RM P GCP ++Y+LM CW ++ +RP FA + + + Sbjct: 325 YPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQE 384 Query: 633 V 633 Sbjct: 385 S 385 Score = 155 bits (393), Expect = 4e-38, Method: Composition-based stats. Identities = 84/427 (19%), Positives = 147/427 (34%), Gaps = 78/427 (18%) Query: 1 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 60 MAS +S ++ G ++R AE YL+ G+ +G +L+R+S + G ++S+ + + Sbjct: 1 MAS---VNSLEKHSWYHGPVSRNAAE-YLLSSGI-NGSFLVRESESSPGQRSISLRYEGR 55 Query: 61 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPF---NRPQ--GVQP 115 +HY I +G ++ + A+L H+HS +DGL+ L P N+P GV P Sbjct: 56 VYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSP 115 Query: 116 KTGPFE------DLKENLIREYVKQTWNLQGQ--ALEQAIISQKP---------QLEKLI 158 +E +K L + + + +L A+ + K + ++ Sbjct: 116 NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVM 175 Query: 159 ATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFL--IRARDNNGSYALCLLHEGKVLHY 216 H + G +R E ++ T G L +R + A+ LL+ Sbjct: 176 KEIKHPNLVQLLGVCTR-EPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT---- 230 Query: 217 RIDKDKTGKLSIPEGKKFDTLWQ---LV--EHYSYKADGLLRVLTVPCQKIGTQGNVNFG 271 + + L LV H AD L L G + G Sbjct: 231 --QISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMT-----GDTYTAHAG 283 Query: 272 GRPQLPGSHPA------------TWSAGGIISRIKSYSF-PKPGHRKSS------PAQGN 312 + + + P W+ G ++ I +Y P PG S Sbjct: 284 AKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRM 343 Query: 313 RQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTL 372 + YE A W + P D + + E + + D Sbjct: 344 ERPEGCPEKVYELMRACWQWN--------PSDRPSFAEIHQAFETMFQESSISDEV---- 391 Query: 373 EDKELGS 379 +KELG Sbjct: 392 -EKELGK 397 >2FO0-A nrPDB Length = 495 Score = 362 bits (930), Expect = e-100, Method: Composition-based stats. Identities = 147/475 (30%), Positives = 221/475 (46%), Gaps = 100/475 (21%) Query: 160 TTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDN-NGSYALCLLHEGKVLHYRI 218 + EK W+HG +SR +E L+ S NG FL+R ++ G ++ L +EG+V HYRI Sbjct: 96 VNSLEKHSWYHGPVSRNAAE--YLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRI 153 Query: 219 DKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPG 278 + GKL F +L Sbjct: 154 NTASDGKL------------------------------------YVSSESRFNTLAELV- 176 Query: 279 SHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQR 338 H + A G+I+ + +P P K + P W Sbjct: 177 -HHHSTVADGLIT---TLHYPAPKRNKPT------------VYGVSPNYDKW-------- 212 Query: 339 EALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKT 398 ++R +T++ K LG G +G V +G + KK T Sbjct: 213 -------------------------EMERTDITMKHK-LGGGQYGEVYEGVW--KKYSLT 244 Query: 399 VAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAES-WMLVMEMAELGPLN 457 VAVK LK D +E L EA VM+++ +P +V+++G+C E + ++ E G L Sbjct: 245 VAVKTLK---EDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLL 301 Query: 458 KYLQQ--NRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGL 515 YL++ + V ++ + Q+S M+YLE+ NF+HR+LAARN L+ H K++DFGL Sbjct: 302 DYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGL 361 Query: 516 SKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG 575 S+ + D Y A K+P+KW APE + Y KFS KSDVW+FGVL+WE +YG PY G Sbjct: 362 SRLMTGD--TYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPG 419 Query: 576 MKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYY 630 + S+V +LEK RM P GCP ++Y+LM CW ++ +RP FA + + Sbjct: 420 IDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMF 474 Score = 157 bits (397), Expect = 1e-38, Method: Composition-based stats. Identities = 78/412 (18%), Positives = 144/412 (34%), Gaps = 63/412 (15%) Query: 7 ADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTI 66 +S ++ G ++R AE YL+ G+ +G +L+R+S + G ++S+ + + +HY I Sbjct: 96 VNSLEKHSWYHGPVSRNAAE-YLLSSGI-NGSFLVRESESSPGQRSISLRYEGRVYHYRI 153 Query: 67 ERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPF---NRPQ--GVQPKTGPFE 121 +G ++ + A+L H+HS +DGL+ L P N+P GV P +E Sbjct: 154 NTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWE 213 Query: 122 ------DLKENLIREYVKQTWNLQGQ--ALEQAIISQKP---------QLEKLIATTAHE 164 +K L + + + +L A+ + K + ++ H Sbjct: 214 MERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHP 273 Query: 165 KMPWFHGKISREESEQIVLIGSKTNGKFL--IRARDNNGSYALCLLHEGKVLHYRIDKDK 222 + G +R E ++ T G L +R + A+ LL+ Sbjct: 274 NLVQLLGVCTR-EPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT------QISS 326 Query: 223 TGKLSIPEGKKFDTLWQ---LV--EHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLP 277 + + L LV H AD L L G + G + + Sbjct: 327 AMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMT-----GDTYTAHAGAKFPIK 381 Query: 278 GSHPA------------TWSAGGIISRIKSYSF-PKPGHRKSS------PAQGNRQESTV 318 + P W+ G ++ I +Y P PG S + Sbjct: 382 WTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGC 441 Query: 319 SFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLL 370 YE A W + R + + +E+ + + E L ++ L Sbjct: 442 PEKVYELMRACWQWNPS-DRPSFAEIHQAFETMFQESSISDEVEKELGKENL 492 >4XI2-A nrPDB Length = 446 Score = 356 bits (913), Expect = 2e-98, Method: Composition-based stats. Identities = 135/479 (28%), Positives = 211/479 (44%), Gaps = 92/479 (19%) Query: 152 PQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEG 211 P A + E W+ ++R ++EQ++ K G F++R G Y + + + Sbjct: 52 PSNYITEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGG-FIVRDSSKAGKYTVSVFAKS 110 Query: 212 KVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFG 271 TG+ P+G ++ HY V + P + F Sbjct: 111 -----------TGE---PQG--------VIRHYV--------VCSTPQSQYYLAEKHLFS 140 Query: 272 GRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWA 331 P+L H ++ G+ISR+K +P K++P ST W Sbjct: 141 TIPELINYHQH--NSAGLISRLK---YPVSKQNKNAP-------STAGLG-----YGSW- 182 Query: 332 ADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQ 391 +D K LT KELG+G FG VK G ++ Sbjct: 183 --------------------------------EIDPKDLTFL-KELGTGQFGVVKYGKWR 209 Query: 392 MKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAE-SWMLVMEM 450 + VA+K+++ + DE + EA VM L + +V++ G+C + ++ E Sbjct: 210 GQY---DVAIKMIREGSMSE---DEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEY 263 Query: 451 AELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAK 509 G L YL++ RH + + ++E+ V M+YLE F+HRDLAARN L+ Q K Sbjct: 264 MANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVK 323 Query: 510 ISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYG 569 +SDFGLS+ + DE Y + K+PV+W PE + Y KFSSKSD+W+FGVLMWE +S G Sbjct: 324 VSDFGLSRYVLDDE--YTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLG 381 Query: 570 QKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 + PY SE + +G R+ P +Y +M CW + RP F + + + Sbjct: 382 KMPYERFTNSETAEHIAQGLRLYRPHLASERVYTIMYSCWHEKADERPSFKILLSNILD 440 Score = 83.9 bits (206), Expect = 2e-16, Method: Composition-based stats. Identities = 71/387 (18%), Positives = 122/387 (31%), Gaps = 66/387 (17%) Query: 8 DSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSV---AHGRK---A 61 DS ++ ++TR +AE L Q G G +++R S G + +SV + G Sbjct: 61 DSIEMYEWYSKHMTRSQAEQLLKQEGKEGG-FIVRDSSKA-GKYTVSVFAKSTGEPQGVI 118 Query: 62 HHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPF-----NRPQGVQPK 116 HY + Y +A ++ +L +YH S GL+ LK P N P Sbjct: 119 RHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSKQNKNAPSTAGLG 178 Query: 117 TGPFE------DLKENLIREYVK----QTWNLQGQALEQAIISQKPQLEKLIATTAHEKM 166 G +E + L W Q + I ++ I Sbjct: 179 YGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMM- 237 Query: 167 PWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLH-YRIDKDKTGK 225 +S E+ Q+ + +K F+I NG L + ++ H ++ + Sbjct: 238 -----NLSHEKLVQLYGVCTKQRPIFIITEYMANGCL---LNYLREMRHRFQTQQLLEMC 289 Query: 226 LSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVN----------FGGRPQ 275 + E ++ Q + + A V K+ G G + Sbjct: 290 KDVCEAMEYLESKQFL--HRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFP 347 Query: 276 LPGSHPAT------------WSAGGIISRIKSYS-FPKPGHRKSSPAQ------GNRQES 316 + S P W+ G ++ I S P S A+ + Sbjct: 348 VRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPH 407 Query: 317 TVSFNPYEPELAPW--AADKGPQREAL 341 S Y + W AD+ P + L Sbjct: 408 LASERVYTIMYSCWHEKADERPSFKIL 434 >4XZ1-A nrPDB Length = 262 Score = 354 bits (908), Expect = 9e-98, Method: Composition-based stats. Identities = 145/259 (55%), Positives = 194/259 (74%) Query: 6 MADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYT 65 M D A HLPFF+G+I+R EAE++L GM+DGL+LLRQ LGG+ LS+ H + HH+ Sbjct: 4 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP 63 Query: 66 IERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKE 125 IER+LNGTYAIAGG+ H PA+LC ++S++ DGL C L+KP NRP G++P+ G F+ L++ Sbjct: 64 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDSLRD 123 Query: 126 NLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIG 185 ++R+YV+QTW L+G+ALEQAIISQ PQ+EKLIATTAHE+MPW+H ++REE+E+ + G Sbjct: 124 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG 183 Query: 186 SKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYS 245 ++T+GKFL+R R G+YAL L++ V HY I +DK GK IPEG KFDTLWQLVE+ Sbjct: 184 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK 243 Query: 246 YKADGLLRVLTVPCQKIGT 264 KADGL+ L C Sbjct: 244 LKADGLIYCLKEACPNSSA 262 >1U59-A nrPDB Length = 287 Score = 344 bits (882), Expect = 7e-95, Method: Composition-based stats. Identities = 168/276 (60%), Positives = 214/276 (77%), Gaps = 2/276 (0%) Query: 361 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 420 K+++L R L + D ELG GNFG+V++G Y+M+K VA+K+LK + + A +E++ E Sbjct: 2 KKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QGTEKADTEEMMRE 60 Query: 421 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQ-QNRHVKDKNIIELVHQVS 479 A +M QLDNPYIVR+IG+C+AE+ MLVMEMA GPL+K+L + + N+ EL+HQVS Sbjct: 61 AQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVS 120 Query: 480 MGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY 539 MGMKYLEE NFVHRDLAARNVLLV +HYAKISDFGLSKAL AD++YY A++ GKWP+KWY Sbjct: 121 MGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY 180 Query: 540 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR 599 APECIN+ KFSS+SDVWS+GV MWEA SYGQKPY+ MKG EV A +E+G+RM CP CP Sbjct: 181 APECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPP 240 Query: 600 EMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 E+Y LM+ CW Y E+RP F VE R+R YY + + Sbjct: 241 ELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLAS 276 Score = 33.1 bits (74), Expect = 0.45, Method: Composition-based stats. Identities = 45/276 (16%), Positives = 91/276 (32%), Gaps = 31/276 (11%) Query: 118 GPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEK-MPWFHGKISRE 176 G F +++ + R KQ ++ + L+Q + A H+ P+ I Sbjct: 21 GNFGSVRQGVYRMRKKQI-DVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC 79 Query: 177 ESEQIVL----IGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGK 232 ++E ++L G KFL+ R+ + + + ++LH + G + E Sbjct: 80 QAEALMLVMEMAGGGPLHKFLVGKREE-----IPVSNVAELLH----QVSMGMKYLEEKN 130 Query: 233 K-FDTLWQ----LV-EHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSA 286 L LV HY+ +D L+ + G+ L P + Sbjct: 131 FVHRDLAARNVLLVNRHYAKISD---FGLSKALGADDSYYTARSAGKWPLKWYAPECINF 187 Query: 287 GGIISRIKSYSFPKPGHRKSS----PAQGNRQESTVSFNPYEPELAPWAADKGPQREALP 342 SR +S+ S P + + ++F + + P E Sbjct: 188 RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMEC--PPECPP-ELYA 244 Query: 343 MDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELG 378 + ++ + + D + E + +L K G Sbjct: 245 LMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEG 280 >4CSV-A nrPDB Length = 275 Score = 331 bits (849), Expect = 5e-91, Method: Composition-based stats. Identities = 115/274 (41%), Positives = 165/274 (60%), Gaps = 11/274 (4%) Query: 360 PKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLA 419 + + R +TLE ++LGSG FG V +G ++ + VAVK LK +E L Sbjct: 3 HDKWEIPRSEITLE-RKLGSGQFGEVYEGKWRNYNI--EVAVKTLKEGTMS---VEEFLQ 56 Query: 420 EANVMQQLDNPYIVRMIGICEAESW-MLVMEMAELGPLNKYLQ--QNRHVKDKNIIELVH 476 EA +M++L +P +V++ G+C E ++ E G L YL+ + V + ++++ Sbjct: 57 EAQIMKKLKHPNLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAA 116 Query: 477 QVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPV 536 QV+ GM YLE NF+HRDLAARN L+ + K++DFGL++ + DE Y A+ K+P+ Sbjct: 117 QVASGMAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDE--YTARAGAKFPI 174 Query: 537 KWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAG 596 KW APE I+Y +FS KSDVW+FG+L+WE F+YGQ PY GM GSEV +E+G RM P G Sbjct: 175 KWTAPEAISYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQG 234 Query: 597 CPREMYDLMNLCWTYDVENRPGFAAVELRLRNYY 630 CP E+Y+LM CW E RP FA L + Sbjct: 235 CPEEIYELMLQCWNKSPEERPTFAETLHALETMF 268 >2XYN-A nrPDB Length = 292 Score = 313 bits (801), Expect = 2e-85, Method: Composition-based stats. Identities = 111/277 (40%), Positives = 161/277 (58%), Gaps = 11/277 (3%) Query: 360 PKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLA 419 + ++R +T++ K LG G +G V G + KK TVAVK LK D +E L Sbjct: 24 MDKWEMERTDITMKHK-LGGGQYGEVYVGVW--KKYSLTVAVKTLK---EDTMEVEEFLK 77 Query: 420 EANVMQQLDNPYIVRMIGICE-AESWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVH 476 EA VM+++ +P +V+++G+C + +V E G L YL++ V ++ + Sbjct: 78 EAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMAT 137 Query: 477 QVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPV 536 Q+S M+YLE+ NF+HRDLAARN L+ H K++DFGLS+ + D Y A K+P+ Sbjct: 138 QISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGD--TYTAHAGAKFPI 195 Query: 537 KWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAG 596 KW APE + Y FS KSDVW+FGVL+WE +YG PY G+ S+V +LEKG RM P G Sbjct: 196 KWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEG 255 Query: 597 CPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDV 633 CP ++Y+LM CW + +RP FA ++D Sbjct: 256 CPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDS 292 >2PL0-A nrPDB Length = 289 Score = 311 bits (798), Expect = 4e-85, Method: Composition-based stats. Identities = 110/290 (37%), Positives = 164/290 (56%), Gaps = 17/290 (5%) Query: 343 MDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVK 402 M T+ + P+ + E + R+ L L ++ LG+G FG V GYY VAVK Sbjct: 4 MQTQKPQKPWWEDEW------EVPRETLKLVER-LGAGQFGEVWMGYY---NGHTKVAVK 53 Query: 403 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQ- 461 LK + P D LAEAN+M+QL + +VR+ + E ++ E E G L +L+ Sbjct: 54 SLKQGSMSP---DAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKT 110 Query: 462 -QNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALR 520 + ++++ Q++ GM ++EE N++HRDL A N+L+ KI+DFGL++ + Sbjct: 111 PSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIE 170 Query: 521 ADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSE 580 +E Y A+ K+P+KW APE INY F+ KSDVWSFG+L+ E ++G+ PY GM E Sbjct: 171 DNE--YTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPE 228 Query: 581 VTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYY 630 V LE+G RM P CP E+Y LM LCW E+RP F + L +++ Sbjct: 229 VIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFF 278 >3DKO-A nrPDB Length = 318 Score = 310 bits (794), Expect = 1e-84, Method: Composition-based stats. Identities = 103/288 (35%), Positives = 159/288 (55%), Gaps = 8/288 (2%) Query: 343 MDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMK-KVVKTVAV 401 +D E YE P + LD + +E + +G+G FG V G ++ K VA+ Sbjct: 21 IDPETYEDPNRA---VHQFAKELDASCIKIE-RVIGAGEFGEVCSGRLKLPGKRDVAVAI 76 Query: 402 KILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICE-AESWMLVMEMAELGPLNKYL 460 K LK + +D L EA++M Q D+P +V + G+ + M+V+E E G L+ +L Sbjct: 77 KTLKVGYTEKQRRD-FLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFL 135 Query: 461 QQN-RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL 519 +++ ++ ++ ++ GM+YL + +VHRDLAARN+L+ + K+SDFGLS+ + Sbjct: 136 RKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVI 195 Query: 520 RADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGS 579 D T GK PV+W APE I Y KF+S SDVWS+G++MWE SYG++PY M Sbjct: 196 EDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQ 255 Query: 580 EVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 +V +E+G R+ P CP ++ LM CW + RP F + L Sbjct: 256 DVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQIVGILD 303 >2J0K-A nrPDB Length = 656 Score = 310 bits (794), Expect = 1e-84, Method: Composition-based stats. Identities = 116/365 (31%), Positives = 187/365 (51%), Gaps = 15/365 (4%) Query: 271 GGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQ-ESTVSFNPYEPELAP 329 G L + P+ A + I Y G +S + ++ E + P Sbjct: 292 GAPEPLTVTAPSLTIAENMADLIDGYCRLVNGATQSFIIRPQKEGERALPSIPKLANNE- 350 Query: 330 WAADKGPQREALPMDTEVYESPYADPEE----IRPKEVYLDRKLLTLEDKELGSGNFGTV 385 +G + + + + D E+ ++ + R+ + L + +G G FG V Sbjct: 351 ---KQGVRSHTVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIEL-GRCIGEGQFGDV 406 Query: 386 KKGYY-QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESW 444 +G Y + VA+K KN +D ++++ L EA M+Q D+P+IV++IG+ Sbjct: 407 HQGIYMSPENPAMAVAIKTCKNCTSDS-VREKFLQEALTMRQFDHPHIVKLIGVITENPV 465 Query: 445 MLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV 503 ++ME+ LG L +LQ + + ++I +Q+S + YLE FVHRD+AARNVL+ Sbjct: 466 WIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVS 525 Query: 504 TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMW 563 K+ DFGLS+ + +++ Y + GK P+KW APE IN+ +F+S SDVW FGV MW Sbjct: 526 ATDCVKLGDFGLSRYM--EDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMW 583 Query: 564 EAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVE 623 E +G KP++G+K ++V +E GER+ P CP +Y LM CW YD RP F ++ Sbjct: 584 EILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELK 643 Query: 624 LRLRN 628 +L Sbjct: 644 AQLST 648 >4P5Q-A nrPDB Length = 361 Score = 310 bits (794), Expect = 1e-84, Method: Composition-based stats. Identities = 101/280 (36%), Positives = 158/280 (56%), Gaps = 5/280 (1%) Query: 351 PYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQM-KKVVKTVAVKILKNEAN 409 P + + LD +++ DK +G+G FG V G ++ K +VA+K LK Sbjct: 16 PRGSTQTVHEFAKELDATNISI-DKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYT 74 Query: 410 DPALKDELLAEANVMQQLDNPYIVRMIGICE-AESWMLVMEMAELGPLNKYLQQNR-HVK 467 + +D L EA++M Q D+P I+R+ G+ ++ M+V E E G L+ +L+++ Sbjct: 75 EKQRRD-FLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFT 133 Query: 468 DKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYK 527 ++ ++ ++ GMKYL + +VHRDLAARN+L+ + K+SDFGLS+ L D Sbjct: 134 VIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAY 193 Query: 528 AQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 GK P++W +PE I Y KF+S SDVWS+G+++WE SYG++PY M +V +++ Sbjct: 194 TTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDE 253 Query: 588 GERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 G R+ P CP +Y LM CW D NRP F + L Sbjct: 254 GYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILD 293 >4EBW-A nrPDB Length = 304 Score = 310 bits (793), Expect = 2e-84, Method: Composition-based stats. Identities = 103/271 (38%), Positives = 162/271 (59%), Gaps = 6/271 (2%) Query: 360 PKEVYLDRKLLTLEDKELGSGNFGTVKKGYY-QMKKVVKTVAVKILKNEANDPALKDELL 418 ++ + R+ + L + +G G FG V +G Y + VA+K KN +D ++++ L Sbjct: 30 TRDYEIQRERIEL-GRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDS-VREKFL 87 Query: 419 AEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQ 477 EA M+Q D+P+IV++IG+ ++ME+ LG L +LQ ++ + ++I +Q Sbjct: 88 QEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQ 147 Query: 478 VSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVK 537 +S + YLE FVHRD+AARNVL+ + K+ DFGLS+ + +++ Y + GK P+K Sbjct: 148 LSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYM--EDSTYYKASKGKLPIK 205 Query: 538 WYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGC 597 W APE IN+ +F+S SDVW FGV MWE +G KP++G+K ++V +E GER+ P C Sbjct: 206 WMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNC 265 Query: 598 PREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 P +Y LM CW YD RP F ++ +L Sbjct: 266 PPTLYSLMTKCWAYDPSRRPRFTELKAQLST 296 >6NPU-A nrPDB Length = 298 Score = 309 bits (792), Expect = 2e-84, Method: Composition-based stats. Identities = 110/273 (40%), Positives = 164/273 (60%), Gaps = 11/273 (4%) Query: 361 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 420 + ++R +T++ K LG G +G V +G + KK TVAVK LK D +E L E Sbjct: 19 DKWEMERTDITMKHK-LGGGQYGEVYEGVW--KKYSLTVAVKTLK---EDTMEVEEFLKE 72 Query: 421 ANVMQQLDNPYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQ 477 A VM+++ +P +V+++G+C E + ++ E G L YL++ + V ++ + Q Sbjct: 73 AAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQ 132 Query: 478 VSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVK 537 +S M+YLE+ NF+HRDLAARN L+ H K++DFGLS+ + D Y A K+P+K Sbjct: 133 ISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGD--TYTAHAGAKFPIK 190 Query: 538 WYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGC 597 W APE + Y KFS KSDVW+FGVL+WE +YG PY G+ S+V +LEK RM P GC Sbjct: 191 WTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGC 250 Query: 598 PREMYDLMNLCWTYDVENRPGFAAVELRLRNYY 630 P ++Y+LM CW ++ +RP FA + + Sbjct: 251 PEKVYELMRACWQWNPSDRPSFAEIHQAFETMF 283 >2Y6O-A nrPDB Length = 291 Score = 308 bits (788), Expect = 6e-84, Method: Composition-based stats. Identities = 98/273 (35%), Positives = 153/273 (56%), Gaps = 5/273 (1%) Query: 358 IRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKT-VAVKILKNEANDPALKDE 416 +R +D + +E K +G G FG V G ++ + VA+K LK D +D Sbjct: 4 VREFAKEIDASCIKIE-KVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRD- 61 Query: 417 LLAEANVMQQLDNPYIVRMIGICEA-ESWMLVMEMAELGPLNKYLQQN-RHVKDKNIIEL 474 L+EA++M Q D+P I+ + G+ + M++ E E G L+ +L++N ++ + Sbjct: 62 FLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGM 121 Query: 475 VHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKW 534 + + GMKYL + ++VHRDLAARN+L+ + K+SDFG+S+ L D GK Sbjct: 122 LRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKI 181 Query: 535 PVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP 594 P++W APE I Y KF+S SDVWS+G++MWE SYG++PY M +V +E+G R+ P Sbjct: 182 PIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPP 241 Query: 595 AGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 CP ++ LM CW + +RP F + L Sbjct: 242 MDCPIALHQLMLDCWQKERSDRPKFGQIVNMLD 274 >2R2P-A nrPDB Length = 295 Score = 307 bits (786), Expect = 1e-83, Method: Composition-based stats. Identities = 101/280 (36%), Positives = 158/280 (56%), Gaps = 6/280 (2%) Query: 352 YADPEE-IRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKT-VAVKILKNEAN 409 Y DP + + ++ +T+E + +G+G FG V G ++ + VA+K LK Sbjct: 5 YEDPNQAVHEFAKEIEASCITIE-RVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYT 63 Query: 410 DPALKDELLAEANVMQQLDNPYIVRMIGICE-AESWMLVMEMAELGPLNKYLQQN-RHVK 467 + +D L EA++M Q D+P I+ + G+ ++ M+V E E G L+ +L++N Sbjct: 64 EKQRRD-FLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFT 122 Query: 468 DKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYK 527 ++ ++ +S GMKYL + +VHRDLAARN+L+ + K+SDFGLS+ L D Sbjct: 123 VIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAY 182 Query: 528 AQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 GK P++W APE I + KF+S SDVWS+G++MWE SYG++PY M +V +E+ Sbjct: 183 TTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEE 242 Query: 588 GERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 G R+ P CP +Y LM CW + +RP F + L Sbjct: 243 GYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLD 282 >2H8H-A nrPDB Length = 535 Score = 306 bits (785), Expect = 1e-83, Method: Composition-based stats. Identities = 98/273 (35%), Positives = 151/273 (55%), Gaps = 11/273 (4%) Query: 363 VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEAN 422 + R+ L LE K LG G FG V G + VA+K LK P + L EA Sbjct: 262 WEIPRESLRLEVK-LGQGCFGEVWMGTWNGTT---RVAIKTLKPGTMSP---EAFLQEAQ 314 Query: 423 VMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQN--RHVKDKNIIELVHQVSM 480 VM++L + +V++ + E +V E G L +L+ ++++ ++++ Q++ Sbjct: 315 VMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIAS 374 Query: 481 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540 GM Y+E N+VHRDL A N+L+ K++DFGL++ + +E Y A+ K+P+KW A Sbjct: 375 GMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE--YTARQGAKFPIKWTA 432 Query: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600 PE Y +F+ KSDVWSFG+L+ E + G+ PY GM EV +E+G RM CP CP Sbjct: 433 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES 492 Query: 601 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDV 633 ++DLM CW + E RP F ++ L +Y+ Sbjct: 493 LHDLMCQCWRKEPEERPTFEYLQAFLEDYFTST 525 Score = 182 bits (462), Expect = 4e-46, Method: Composition-based stats. Identities = 79/398 (19%), Positives = 133/398 (33%), Gaps = 68/398 (17%) Query: 7 ADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVA-----HGRKA 61 +DS ++FG ITR E+E L+ G +L+R+S G + LSV+ G Sbjct: 142 SDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNV 201 Query: 62 HHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLV------CLLKKPFNRPQGVQP 115 HY I + +G + I S L Y+S+ +DGL C KP + Sbjct: 202 KHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDA 261 Query: 116 KTGPFEDLK------ENLIREYVKQTWNLQGQALEQAIISQKP---------QLEKLIAT 160 P E L+ + E TWN + AI + KP Q +++ Sbjct: 262 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR---VAIKTLKPGTMSPEAFLQEAQVMKK 318 Query: 161 TAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDK 220 HEK+ + +S E +++ + GS L L + R+ + Sbjct: 319 LRHEKLVQLYAVVSEEP-------------IYIVTEYMSKGS-LLDFLKGETGKYLRLPQ 364 Query: 221 DKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNF---------- 270 I G + V H +A +L + C K+ G Sbjct: 365 LVDMAAQIASGMAYVERMNYV-HRDLRAANILVGENLVC-KVADFGLARLIEDNEYTARQ 422 Query: 271 GGRPQLPGSHPA------------TWSAGGIISRIKSYS-FPKPGHRKSSPAQGNRQEST 317 G + + + P WS G +++ + + P PG + Sbjct: 423 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR 482 Query: 318 VSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADP 355 + P PE + ++E T Y + + Sbjct: 483 MPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLED 520 Score = 119 bits (298), Expect = 4e-27, Method: Composition-based stats. Identities = 42/120 (35%), Positives = 62/120 (51%), Gaps = 8/120 (6%) Query: 157 LIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCL----LHEG 211 + + + + W+ GKI+R ESE+++L G FL+R + G+Y L + +G Sbjct: 139 VAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKG 198 Query: 212 -KVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQ--KIGTQGNV 268 V HY+I K +G I +F++L QLV +YS ADGL LT C K TQG Sbjct: 199 LNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLA 258 >6F3F-A nrPDB Length = 455 Score = 306 bits (784), Expect = 2e-83, Method: Composition-based stats. Identities = 98/273 (35%), Positives = 151/273 (55%), Gaps = 11/273 (4%) Query: 363 VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEAN 422 + R+ L LE K LG G FG V G + VA+K LK P + L EA Sbjct: 182 WEIPRESLRLEVK-LGQGCFGEVWMGTWNGTT---RVAIKTLKPGTMSP---EAFLQEAQ 234 Query: 423 VMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQN--RHVKDKNIIELVHQVSM 480 VM++L + +V++ + E +V E G L +L+ ++++ ++++ Q++ Sbjct: 235 VMKKLRHEKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIAS 294 Query: 481 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540 GM Y+E N+VHRDL A N+L+ K++DFGL++ + +E Y A+ K+P+KW A Sbjct: 295 GMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE--YTARQGAKFPIKWTA 352 Query: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600 PE Y +F+ KSDVWSFG+L+ E + G+ PY GM EV +E+G RM CP CP Sbjct: 353 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES 412 Query: 601 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDV 633 ++DLM CW + E RP F ++ L +Y+ Sbjct: 413 LHDLMCQCWRKEPEERPTFEYLQAFLEDYFTST 445 Score = 184 bits (467), Expect = 1e-46, Method: Composition-based stats. Identities = 80/398 (20%), Positives = 133/398 (33%), Gaps = 68/398 (17%) Query: 7 ADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVA-----HGRKA 61 +DS ++FG ITR E+E L+ G +L+R+S G + LSV+ G Sbjct: 62 SDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNV 121 Query: 62 HHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLV------CLLKKPFNRPQGVQP 115 HY I + +G + I S L Y+S+ +DGL C KP + Sbjct: 122 KHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDA 181 Query: 116 KTGPFEDLK------ENLIREYVKQTWNLQGQALEQAIISQKP---------QLEKLIAT 160 P E L+ + E TWN + AI + KP Q +++ Sbjct: 182 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR---VAIKTLKPGTMSPEAFLQEAQVMKK 238 Query: 161 TAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDK 220 HEK+ + +S E +++ N GS L L + R+ + Sbjct: 239 LRHEKLVQLYAVVSEEP-------------IYIVTEYMNKGS-LLDFLKGETGKYLRLPQ 284 Query: 221 DKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNF---------- 270 I G + V H +A +L + C K+ G Sbjct: 285 LVDMSAQIASGMAYVERMNYV-HRDLRAANILVGENLVC-KVADFGLARLIEDNEYTARQ 342 Query: 271 GGRPQLPGSHPA------------TWSAGGIISRIKSYS-FPKPGHRKSSPAQGNRQEST 317 G + + + P WS G +++ + + P PG + Sbjct: 343 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR 402 Query: 318 VSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADP 355 + P PE + ++E T Y + + Sbjct: 403 MPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLED 440 Score = 119 bits (299), Expect = 3e-27, Method: Composition-based stats. Identities = 42/120 (35%), Positives = 62/120 (51%), Gaps = 8/120 (6%) Query: 157 LIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCL----LHEG 211 + + + + W+ GKI+R ESE+++L G FL+R + G+Y L + +G Sbjct: 59 VAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKG 118 Query: 212 -KVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQ--KIGTQGNV 268 V HY+I K +G I +F++L QLV +YS ADGL LT C K TQG Sbjct: 119 LNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLA 178 >2DQ7-X nrPDB Length = 283 Score = 306 bits (783), Expect = 3e-83, Method: Composition-based stats. Identities = 99/270 (36%), Positives = 152/270 (56%), Gaps = 11/270 (4%) Query: 363 VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEAN 422 + R+ L L K LG+G FG V G + VA+K LK P + L EA Sbjct: 4 WEIPRESLQLI-KRLGNGQFGEVWMGTW---NGNTKVAIKTLKPGTMSP---ESFLEEAQ 56 Query: 423 VMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQ--QNRHVKDKNIIELVHQVSM 480 +M++L + +V++ + E +V E G L +L+ + R +K N++++ QV+ Sbjct: 57 IMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAA 116 Query: 481 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540 GM Y+E N++HRDL + N+L+ KI+DFGL++ + +E Y A+ K+P+KW A Sbjct: 117 GMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNE--YTARQGAKFPIKWTA 174 Query: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600 PE Y +F+ KSDVWSFG+L+ E + G+ PY GM EV +E+G RM CP CP Sbjct: 175 PEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPIS 234 Query: 601 MYDLMNLCWTYDVENRPGFAAVELRLRNYY 630 +++LM CW D E RP F ++ L +Y+ Sbjct: 235 LHELMIHCWKKDPEERPTFEYLQSFLEDYF 264 Score = 44.6 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 36/230 (15%), Positives = 69/230 (30%), Gaps = 57/230 (24%) Query: 113 VQPKTGPFEDLK------ENLIREYVKQTWNLQGQALEQAIISQKP---------QLEKL 157 P E L+ E TWN + AI + KP + ++ Sbjct: 1 KDVWEIPRESLQLIKRLGNGQFGEVWMGTWNG---NTKVAIKTLKPGTMSPESFLEEAQI 57 Query: 158 IATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYR 217 + H+K+ + +S E +++ N GS L L +G+ + Sbjct: 58 MKKLKHDKLVQLYAVVSEEP-------------IYIVTEYMNKGS-LLDFLKDGEGRALK 103 Query: 218 IDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNF------- 270 + + G + + H ++ +L + C KI G Sbjct: 104 LPNLVDMAAQVAAGMAYIERMNYI-HRDLRSANILVGNGLIC-KIADFGLARLIEDNEYT 161 Query: 271 ---GGRPQLPGSHPA------------TWSAGGIISRIKSYS-FPKPGHR 304 G + + + P WS G +++ + + P PG Sbjct: 162 ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMN 211 >1JPA-A nrPDB Length = 312 Score = 306 bits (783), Expect = 3e-83, Method: Composition-based stats. Identities = 102/282 (36%), Positives = 163/282 (57%), Gaps = 8/282 (2%) Query: 352 YADPEE-IRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKT-VAVKILKNEAN 409 + DP E +R +D + +E + +G+G FG V G+ ++ + VA+K LK+ Sbjct: 16 FEDPNEAVREFAKEIDISCVKIE-QVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYT 74 Query: 410 DPALKDELLAEANVMQQLDNPYIVRMIGICEAESW-MLVMEMAELGPLNKYLQQN-RHVK 467 + +D L+EA++M Q D+P ++ + G+ + M++ E E G L+ +L+QN Sbjct: 75 EKQRRD-FLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFT 133 Query: 468 DKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRAD--ENY 525 ++ ++ ++ GMKYL + N+VHRDLAARN+L+ + K+SDFGLS+ L D + Sbjct: 134 VIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPT 193 Query: 526 YKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAML 585 Y + GK P++W APE I Y KF+S SDVWS+G++MWE SYG++PY M +V + Sbjct: 194 YTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI 253 Query: 586 EKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 E+ R+ P CP ++ LM CW D +RP F + L Sbjct: 254 EQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLD 295 >5SYS-A nrPDB Length = 286 Score = 304 bits (778), Expect = 1e-82, Method: Composition-based stats. Identities = 98/273 (35%), Positives = 150/273 (54%), Gaps = 11/273 (4%) Query: 363 VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEAN 422 + R+ L LE K LG G FG G + VA+K LK P + L EA Sbjct: 13 WEIPRESLRLEVK-LGQGCFGECWMGTWNGTT---RVAIKTLKPGTMSP---EAFLQEAQ 65 Query: 423 VMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQN--RHVKDKNIIELVHQVSM 480 VM++L + +V++ + E +V E G L +L+ ++++ ++++ Q++ Sbjct: 66 VMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIAS 125 Query: 481 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540 GM Y+E N+VHRDL A N+L+ K++DFGL++ + +E Y A+ K+P+KW A Sbjct: 126 GMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE--YTARQGAKFPIKWTA 183 Query: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600 PE Y +F+ KSDVWSFG+L+ E + G+ PY GM EV +E+G RM CP CP Sbjct: 184 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES 243 Query: 601 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDV 633 ++DLM CW D E RP F ++ L +Y+ Sbjct: 244 LHDLMCQCWRKDPEERPTFEYLQAFLEDYFTST 276 >5MJB-A nrPDB Length = 305 Score = 303 bits (776), Expect = 2e-82, Method: Composition-based stats. Identities = 105/282 (37%), Positives = 164/282 (58%), Gaps = 8/282 (2%) Query: 352 YADPEE-IRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKT-VAVKILKNEAN 409 +DP E +R +D + +E + +G+G FG V KG ++ + VA+K LK + Sbjct: 9 GSDPNEAVREFAKEIDVSFVKIE-EVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYS 67 Query: 410 DPALKDELLAEANVMQQLDNPYIVRMIGICE-AESWMLVMEMAELGPLNKYLQQN-RHVK 467 + +D L+EA++M Q D+ I+R+ G+ + M++ E E L+ +L+QN Sbjct: 68 EKQRRD-FLSEASIMGQFDHRNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFT 126 Query: 468 DKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRAD--ENY 525 ++ ++ ++ GMKYL E N+VHRDLAARN+L+ + K+SDFGLS+ L+ D + Sbjct: 127 VIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPT 186 Query: 526 YKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAML 585 Y + GK PV+W APE I Y KF+S SDVWS+G++MWE S+G++PY M +V + Sbjct: 187 YTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAI 246 Query: 586 EKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 E+ R+ P CP ++ LM CW D +RP FA + L Sbjct: 247 EQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLD 288 >4PDO-A nrPDB Length = 299 Score = 301 bits (771), Expect = 6e-82, Method: Composition-based stats. Identities = 101/280 (36%), Positives = 149/280 (53%), Gaps = 5/280 (1%) Query: 352 YADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTV--AVKILKNEAN 409 Y DP + K K +G+G FG V KG + K V A+K LK Sbjct: 17 YEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYT 76 Query: 410 DPALKDELLAEANVMQQLDNPYIVRMIGICEA-ESWMLVMEMAELGPLNKYLQQN-RHVK 467 + + + L EA +M Q + I+R+ G+ + M++ E E G L+K+L++ Sbjct: 77 EKQ-RVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFS 135 Query: 468 DKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYK 527 ++ ++ ++ GMKYL N+VHRDLAARN+L+ + K+SDFGLS+ L D Sbjct: 136 VLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATY 195 Query: 528 AQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 + GK P++W APE I+Y KF+S SDVWSFG++MWE +YG++PY + EV + Sbjct: 196 TTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAIND 255 Query: 588 GERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 G R+ P CP +Y LM CW + RP FA + L Sbjct: 256 GFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILD 295 >4H1J-A nrPDB Length = 293 Score = 301 bits (770), Expect = 7e-82, Method: Composition-based stats. Identities = 106/268 (39%), Positives = 163/268 (60%), Gaps = 6/268 (2%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKT-VAVKILKNEANDPALKDELLAEANV 423 + R+ + L ++ LG G FG V +G Y K K VAVK K + K++ ++EA + Sbjct: 21 IAREDVVL-NRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDN-KEKFMSEAVI 78 Query: 424 MQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGM 482 M+ LD+P+IV++IGI E E ++ME+ G L YL++N++ +K ++ Q+ M Sbjct: 79 MKNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAM 138 Query: 483 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 542 YLE N VHRD+A RN+L+ + K+ DFGLS+ + DE+YYKA + P+KW +PE Sbjct: 139 AYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASV-TRLPIKWMSPE 196 Query: 543 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 602 IN+ +F++ SDVW F V MWE S+G++P+ ++ +V +LEKG+R+ P CP +Y Sbjct: 197 SINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLY 256 Query: 603 DLMNLCWTYDVENRPGFAAVELRLRNYY 630 LM CW YD +RP F + L + Y Sbjct: 257 TLMTRCWDYDPSDRPRFTELVCSLSDVY 284 >3KUL-B nrPDB Length = 325 Score = 298 bits (763), Expect = 5e-81, Method: Composition-based stats. Identities = 104/289 (35%), Positives = 157/289 (54%), Gaps = 8/289 (2%) Query: 344 DTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKT-VAVK 402 + YE P +E+ R + +K +GSG+ G V G ++ VA+K Sbjct: 28 EPHTYEEPGRAGRS-FTREIEASRIHI---EKIIGSGDSGEVCYGRLRVPGQRDVPVAIK 83 Query: 403 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESW-MLVMEMAELGPLNKYLQ 461 LK + + + L+EA++M Q D+P I+R+ G+ M+V E E G L+ +L+ Sbjct: 84 ALKAGYTE-RQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLR 142 Query: 462 QN-RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALR 520 + ++ ++ V GM+YL + +VHRDLAARNVL+ + K+SDFGLS+ L Sbjct: 143 THDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLE 202 Query: 521 ADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSE 580 D + T GK P++W APE I + FSS SDVWSFGV+MWE +YG++PY M + Sbjct: 203 DDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRD 262 Query: 581 VTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNY 629 V + +E+G R+ P GCP ++ LM CW D RP F+ + L Sbjct: 263 VISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVLDAL 311 >2HK5-A nrPDB Length = 270 Score = 298 bits (763), Expect = 5e-81, Method: Composition-based stats. Identities = 100/283 (35%), Positives = 153/283 (54%), Gaps = 17/283 (6%) Query: 349 ESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEA 408 + P+ + R+ L LE K+LG+G FG V Y VAVK +K + Sbjct: 2 QKPWEKDAW------EIPRESLKLE-KKLGAGQFGEVWMATY---NKHTKVAVKTMKPGS 51 Query: 409 NDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHV-- 466 + LAEANVM+ L + +V++ + E ++ E G L +L+ + Sbjct: 52 MS---VEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQ 108 Query: 467 KDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYY 526 +I+ Q++ GM ++E+ N++HRDL A N+L+ KI+DFGL++ + +E Y Sbjct: 109 PLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNE--Y 166 Query: 527 KAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLE 586 A+ K+P+KW APE IN+ F+ KSDVWSFG+L+ E +YG+ PY GM EV LE Sbjct: 167 TAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALE 226 Query: 587 KGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNY 629 +G RM P CP E+Y++M CW E RP F ++ L ++ Sbjct: 227 RGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDF 269 >5L6P-A nrPDB Length = 298 Score = 296 bits (759), Expect = 2e-80, Method: Composition-based stats. Identities = 102/281 (36%), Positives = 160/281 (56%), Gaps = 8/281 (2%) Query: 353 ADPEE-IRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKT-VAVKILKNEAND 410 +DP E +R +D + +E + +G+G FG V +G + + VA+K LK + Sbjct: 3 SDPNEAVREFAKEIDVSCVKIE-EVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTE 61 Query: 411 PALKDELLAEANVMQQLDNPYIVRMIGICE-AESWMLVMEMAELGPLNKYLQQN-RHVKD 468 + + L+EA++M Q D+P I+R+ G+ + M++ E E L+ +L+ N Sbjct: 62 -RQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTV 120 Query: 469 KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRAD--ENYY 526 ++ ++ ++ GMKYL E N+VHRDLAARN+L+ + K+SDFGLS+ L D + Y Sbjct: 121 IQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTY 180 Query: 527 KAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLE 586 + GK P++W APE I Y KF+S SDVWS+G++MWE SYG++PY M +V +E Sbjct: 181 TSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVE 240 Query: 587 KGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 + R+ P CP ++ LM CW D RP F+ + L Sbjct: 241 QDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLD 281 >4E93-A nrPDB Length = 377 Score = 295 bits (755), Expect = 4e-80, Method: Composition-based stats. Identities = 102/271 (37%), Positives = 158/271 (58%), Gaps = 6/271 (2%) Query: 360 PKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLA 419 PK+ ++ + +++G GNFG V G + VAVK + E P LK + L Sbjct: 105 PKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNT--LVAVKSCR-ETLPPDLKAKFLQ 161 Query: 420 EANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQ 477 EA +++Q +P IVR+IG+C + + +VME+ + G +L+ ++ K ++++V Sbjct: 162 EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGD 221 Query: 478 VSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVK 537 + GM+YLE +HRDLAARN L+ ++ KISDFG+S+ AD Y + + PVK Sbjct: 222 AAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSRE-EADGVYAASGGLRQVPVK 280 Query: 538 WYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGC 597 W APE +NY ++SS+SDVWSFG+L+WE FS G PY + + +EKG R+ CP C Sbjct: 281 WTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELC 340 Query: 598 PREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 P ++ LM CW Y+ RP F+ + L++ Sbjct: 341 PDAVFRLMEQCWAYEPGQRPSFSTIYQELQS 371 Score = 68.1 bits (165), Expect = 1e-11, Method: Composition-based stats. Identities = 31/130 (23%), Positives = 55/130 (42%), Gaps = 21/130 (16%) Query: 149 SQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLL 208 S P+++K + HE++ W+HG I R E ++++ +G FL+R Y L +L Sbjct: 1 SMIPEVQKPL----HEQL-WYHGAIPRAEVAELLV----HSGDFLVRESQGKQEYVLSVL 51 Query: 209 HEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNV 268 +G H+ I L EG+ F ++ L++H +L+ G V Sbjct: 52 WDGLPRHFIIQSLDN--LYRLEGEGFPSIPLLIDH----------LLSTQQPLTKKSGVV 99 Query: 269 NFGGRPQLPG 278 P+ Sbjct: 100 LHRAVPKDKW 109 Score = 67.3 bits (163), Expect = 2e-11, Method: Composition-based stats. Identities = 62/387 (16%), Positives = 111/387 (28%), Gaps = 64/387 (16%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74 ++ G I R E + LV G +L+R+S+ + LSV H+ I+ N Sbjct: 15 WYHGAIPRAEVAELLV----HSGDFLVRESQG-KQEYVLSVLWDGLPRHFIIQSLDN--L 67 Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFED--LKENLIREYV 132 G S L + L +R ED L E + R Sbjct: 68 YRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNF 127 Query: 133 KQTWNLQGQALEQAI------ISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGS 186 + ++ + +A + + P L+ A + H I R ++ + + Sbjct: 128 GEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVR-----LIGVCT 182 Query: 187 KTNGKFLIRARDNNGSYALCLLHEG---KVLHY--RIDKDKTGKLSIPEGKKFDTLWQLV 241 + +++ G + L EG +V + G + Sbjct: 183 QKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCI------- 235 Query: 242 EHYSYKADGLLRVLTVPCQKIGTQGNVNFGGR-----------PQLPGSHPA-------- 282 + A V KI G + + P Sbjct: 236 --HRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYS 293 Query: 283 ----TWSAGGIISRIKSYSF-PKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQ 337 WS G ++ S P P + Q R+ PEL P A + + Sbjct: 294 SESDVWSFGILLWETFSLGASPYP----NLSNQQTREFVEKGGRLPCPELCPDAVFRLME 349 Query: 338 R--EALPMDTEVYESPYADPEEIRPKE 362 + P + + Y + + IR + Sbjct: 350 QCWAYEPGQRPSFSTIYQELQSIRKRH 376 >3TT0-A nrPDB Length = 382 Score = 295 bits (755), Expect = 4e-80, Method: Composition-based stats. Identities = 109/301 (36%), Positives = 161/301 (53%), Gaps = 29/301 (9%) Query: 350 SPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKK----GYYQMK-KVVKTVAVKIL 404 S Y PE+ R L R L L K LG G FG V G + K V VAVK+L Sbjct: 54 SEYELPEDPR---WELPRDRLVL-GKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKML 109 Query: 405 KNEANDPALKDELLAEANVMQQL-DNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQ 462 K++A + L D L++E +M+ + + I+ ++G C + +++E A G L +YLQ Sbjct: 110 KSDATEKDLSD-LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQA 168 Query: 463 NRH----------------VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQH 506 R + K+++ +QV+ GM+YL +HRDLAARNVL+ + Sbjct: 169 RRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN 228 Query: 507 YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAF 566 KI+DFGL++ + +YYK T+G+ PVKW APE + ++ +SDVWSFGVL+WE F Sbjct: 229 VMKIADFGLARDIHH-IDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIF 287 Query: 567 SYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 626 + G PY G+ E+ +L++G RM P+ C E+Y +M CW RP F + L Sbjct: 288 TLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 347 Query: 627 R 627 Sbjct: 348 D 348 >2VWV-A nrPDB Length = 302 Score = 294 bits (752), Expect = 9e-80, Method: Composition-based stats. Identities = 97/280 (34%), Positives = 157/280 (56%), Gaps = 8/280 (2%) Query: 354 DPEE-IRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKT-VAVKILKNEANDP 411 DP E +R +D + +E + +G+G FG V +G + ++ VA+K LK + Sbjct: 1 DPNEAVREFAKEIDVSYVKIE-EVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTE- 58 Query: 412 ALKDELLAEANVMQQLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQN-RHVKDK 469 + E L+EA++M Q ++P I+R+ G+ M++ E E G L+ +L+ N Sbjct: 59 RQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVI 118 Query: 470 NIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALR--ADENYYK 527 ++ ++ ++ GM+YL E ++VHRDLAARN+L+ + K+SDFGLS+ L + + Sbjct: 119 QLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTET 178 Query: 528 AQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 + GK P++W APE I + KF+S SD WS+G++MWE S+G++PY M +V +E+ Sbjct: 179 SSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQ 238 Query: 588 GERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 R+ P CP ++ LM CW D RP F V L Sbjct: 239 DYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALD 278 >3GQL-A nrPDB Length = 326 Score = 293 bits (750), Expect = 1e-79, Method: Composition-based stats. Identities = 109/301 (36%), Positives = 161/301 (53%), Gaps = 29/301 (9%) Query: 350 SPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKK----GYYQMK-KVVKTVAVKIL 404 S Y PE+ R L R L L K LG G FG V G + K V VAVK+L Sbjct: 13 SEYELPEDPR---WELPRDRLVL-GKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKML 68 Query: 405 KNEANDPALKDELLAEANVMQQL-DNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQ 462 K++A + L D L++E +M+ + + I+ ++G C + +++E A G L +YLQ Sbjct: 69 KSDATEKDLSD-LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQA 127 Query: 463 NRH----------------VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQH 506 R + K+++ +QV+ GM+YL +HRDLAARNVL+ + Sbjct: 128 RRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN 187 Query: 507 YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAF 566 KI+DFGL++ + +YYK T+G+ PVKW APE + ++ +SDVWSFGVL+WE F Sbjct: 188 VMKIADFGLARDIHH-IDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIF 246 Query: 567 SYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 626 + G PY G+ E+ +L++G RM P+ C E+Y +M CW RP F + L Sbjct: 247 TLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 306 Query: 627 R 627 Sbjct: 307 D 307 >3A4O-X nrPDB Length = 286 Score = 293 bits (750), Expect = 2e-79, Method: Composition-based stats. Identities = 100/271 (36%), Positives = 148/271 (54%), Gaps = 12/271 (4%) Query: 363 VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEAN 422 + R+ + L K LG+G FG V GYY VAVK LK L EAN Sbjct: 8 WEIPRESIKL-VKRLGAGQFGEVWMGYYNNST---KVAVKTLKPGTMS---VQAFLEEAN 60 Query: 423 VMQQLDNPYIVRMIGICE-AESWMLVMEMAELGPLNKYLQ--QNRHVKDKNIIELVHQVS 479 +M+ L + +VR+ + E ++ E G L +L+ + V +I+ Q++ Sbjct: 61 LMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIA 120 Query: 480 MGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY 539 GM Y+E N++HRDL A NVL+ KI+DFGL++ + +E Y A+ K+P+KW Sbjct: 121 EGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNE--YTAREGAKFPIKWT 178 Query: 540 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR 599 APE IN+ F+ KSDVWSFG+L++E +YG+ PY G ++V L +G RM CP Sbjct: 179 APEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPD 238 Query: 600 EMYDLMNLCWTYDVENRPGFAAVELRLRNYY 630 E+YD+M +CW E RP F ++ L ++Y Sbjct: 239 ELYDIMKMCWKEKAEERPTFDYLQSVLDDFY 269 >1AD5-A nrPDB Length = 438 Score = 293 bits (749), Expect = 2e-79, Method: Composition-based stats. Identities = 101/300 (33%), Positives = 155/300 (51%), Gaps = 27/300 (9%) Query: 333 DKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQM 392 D Q+ ++P + + P+ + R+ L LE K+LG+G FG V Y Sbjct: 153 DGLCQKLSVPCMSSKPQKPWEKDAW------EIPRESLKLE-KKLGAGQFGEVWMATY-- 203 Query: 393 KKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAE 452 VAVK +K + + LAEANVM+ L + +V++ + E ++ E Sbjct: 204 -NKHTKVAVKTMKPGSMS---VEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMA 259 Query: 453 LGPLNKYLQQNRHV--KDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKI 510 G L +L+ + +I+ Q++ GM ++E+ N++HRDL A N+L+ KI Sbjct: 260 KGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKI 319 Query: 511 SDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQ 570 +DFGL++ K+P+KW APE IN+ F+ KSDVWSFG+L+ E +YG+ Sbjct: 320 ADFGLAR------------VGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGR 367 Query: 571 KPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYY 630 PY GM EV LE+G RM P CP E+Y++M CW E RP F ++ L ++Y Sbjct: 368 IPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFY 427 Score = 192 bits (489), Expect = 3e-49, Method: Composition-based stats. Identities = 76/333 (22%), Positives = 125/333 (37%), Gaps = 51/333 (15%) Query: 5 GMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSV-----AHGR 59 DS +FF I+R++AE L+ G G +++R S G ++LSV G Sbjct: 56 ARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGD 115 Query: 60 KAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPF--NRPQGVQP-- 115 HY I NG + I+ T ++ +L ++ + +DGL L P ++PQ Sbjct: 116 TVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKD 175 Query: 116 -KTGPFEDLK--ENLIREYVKQTWNLQ-GQALEQAIISQKP---QLEKLIA------TTA 162 P E LK + L + W + + A+ + KP +E +A T Sbjct: 176 AWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQ 235 Query: 163 HEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDK 222 H+K+ H +++E ++I GS L L + + K Sbjct: 236 HDKLVKLHAVVTKEP-------------IYIITEFMAKGS-LLDFLKSDEGSKQPLPKLI 281 Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPA 282 I EG F + H +A +L ++ C KI G G + + + P Sbjct: 282 DFSAQIAEGMAFIEQRNYI-HRDLRAANILVSASLVC-KIADFGLARVGAKFPIKWTAPE 339 Query: 283 ------------TWSAGGIISRIKSYS-FPKPG 302 WS G ++ I +Y P PG Sbjct: 340 AINFGSFTIKSDVWSFGILLMEIVTYGRIPYPG 372 Score = 121 bits (304), Expect = 9e-28, Method: Composition-based stats. Identities = 39/128 (30%), Positives = 56/128 (43%), Gaps = 16/128 (12%) Query: 157 LIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLL-----HE 210 + + E WF ISR+++E+ +L G F+IR + GSY+L + Sbjct: 55 VARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQG 114 Query: 211 GKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNF 270 V HY+I G I F TL +LV+HY DGL + L+VPC Sbjct: 115 DTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPC----------M 164 Query: 271 GGRPQLPG 278 +PQ P Sbjct: 165 SSKPQKPW 172 >4AT3-A nrPDB Length = 299 Score = 293 bits (749), Expect = 2e-79, Method: Composition-based stats. Identities = 90/283 (31%), Positives = 152/283 (53%), Gaps = 21/283 (7%) Query: 364 YLDRKLLTLEDKELGSGNFGTVKKGYYQM---KKVVKTVAVKILKNEANDPALKDELLAE 420 ++ R + L+ +ELG G FG V ++ VAVK LK+ +++ + + E Sbjct: 9 HIKRHNIVLK-RELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDN--ARKDFHRE 65 Query: 421 ANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRH-------------V 466 A ++ L + +IV+ G+C E + ++V E + G LNK+L+ + + Sbjct: 66 AELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTEL 125 Query: 467 KDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYY 526 ++ + Q++ GM YL +FVHRDLA RN L+ KI DFG+S+ + + +YY Sbjct: 126 TQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYS-TDYY 184 Query: 527 KAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLE 586 + H P++W PE I Y KF+++SDVWS GV++WE F+YG++P+ + +EV + Sbjct: 185 RVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECIT 244 Query: 587 KGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNY 629 +G + P CP+E+Y+LM CW + R + L+N Sbjct: 245 QGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNL 287 >2PSQ-A nrPDB Length = 370 Score = 293 bits (749), Expect = 2e-79, Method: Composition-based stats. Identities = 118/352 (33%), Positives = 179/352 (50%), Gaps = 31/352 (8%) Query: 301 PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYE--SPYADPEEI 358 P K + R++ TVS + + R + DT + S Y PE+ Sbjct: 15 PAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDP 74 Query: 359 RPKEVYLDRKLLTLEDKELGSGNFGTVKK----GYYQMK-KVVKTVAVKILKNEANDPAL 413 + R LTL K LG G FG V G + K K TVAVK+LK++A + L Sbjct: 75 K---WEFPRDKLTL-GKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL 130 Query: 414 KDELLAEANVMQQL-DNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQNRH------ 465 D L++E +M+ + + I+ ++G C + +++E A G L +YL+ R Sbjct: 131 SD-LVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS 189 Query: 466 ----------VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGL 515 + K+++ +Q++ GM+YL +HRDLAARNVL+ + KI+DFGL Sbjct: 190 YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGL 249 Query: 516 SKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG 575 ++ + + +YYK T+G+ PVKW APE + ++ +SDVWSFGVLMWE F+ G PY G Sbjct: 250 ARDI-NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 308 Query: 576 MKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 + E+ +L++G RM PA C E+Y +M CW RP F + L Sbjct: 309 IPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLD 360 >4HZS-A nrPDB Length = 341 Score = 292 bits (748), Expect = 3e-79, Method: Composition-based stats. Identities = 105/266 (39%), Positives = 155/266 (58%), Gaps = 5/266 (1%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQM-KKVVKTVAVKILKNEA-NDPALKDELLAEAN 422 + K L L +K LG G+FG V++G + +VAVK LK + + P D+ + E N Sbjct: 9 IGEKDLRLLEK-LGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVN 67 Query: 423 VMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQN-RHVKDKNIIELVHQVSMG 481 M LD+ ++R+ G+ +V E+A LG L L+++ H + QV+ G Sbjct: 68 AMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEG 127 Query: 482 MKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 541 M YLE F+HRDLAARN+LL T+ KI DFGL +AL ++++Y Q H K P W AP Sbjct: 128 MGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAP 187 Query: 542 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK-GERMGCPAGCPRE 600 E + FS SD W FGV +WE F+YGQ+P+ G+ GS++ ++K GER+ P CP++ Sbjct: 188 ESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 247 Query: 601 MYDLMNLCWTYDVENRPGFAAVELRL 626 +Y++M CW + E+RP F A+ L Sbjct: 248 IYNVMVQCWAHKPEDRPTFVALRDFL 273 >6GQK-A nrPDB Length = 328 Score = 292 bits (747), Expect = 4e-79, Method: Composition-based stats. Identities = 102/299 (34%), Positives = 152/299 (50%), Gaps = 26/299 (8%) Query: 352 YADPEEIR-PKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQM---KKVVKTVAVKILKNE 407 Y DP ++ + R L+ K LG+G FG V + Q TVAVK+LK Sbjct: 24 YIDPTQLPYDHKWEFPRNRLSF-GKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPS 82 Query: 408 ANDPALKDELLAEANVMQQL-DNPYIVRMIGICEAESWMLV-MEMAELGPLNKYLQQNR- 464 A ++ L++E V+ L ++ IV ++G C LV E G L +L++ R Sbjct: 83 A-HSTEREALMSELKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRD 141 Query: 465 ---------------HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAK 509 + ++++ +QV+ GM +L N +HRDLAARN+LL + K Sbjct: 142 EFVPYKVAPEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITK 201 Query: 510 ISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYG 569 I DFGL++ ++ D NY + + PVKW APE I ++ +SDVWS+G+ +WE FS G Sbjct: 202 ICDFGLARDIKNDSNYVDKG-NARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLG 260 Query: 570 QKPYRGMK-GSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 PY GM S+ M+++G RM P P EMYD+M CW D + RP F + + Sbjct: 261 SSPYPGMPVDSKFYKMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQIVQDIE 319 >3BBT-B nrPDB Length = 328 Score = 291 bits (744), Expect = 8e-79, Method: Composition-based stats. Identities = 111/270 (41%), Positives = 165/270 (61%), Gaps = 11/270 (4%) Query: 361 KEVYLDRKLLTLEDKELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELL 418 KE L R K LGSG FGTV KG + + + V VA+KIL NE P E + Sbjct: 13 KETELKRV------KVLGSGAFGTVYKGIWVPEGETVKIPVAIKIL-NETTGPKANVEFM 65 Query: 419 AEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQ 477 EA +M +D+P++VR++G+C + + LV ++ G L +Y+ +++ ++ + ++ Q Sbjct: 66 DEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQ 125 Query: 478 VSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVK 537 ++ GM YLEE VHRDLAARNVL+ + ++ KI+DFGL++ L DE Y A GK P+K Sbjct: 126 IAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNAD-GGKMPIK 184 Query: 538 WYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGC 597 W A ECI+Y KF+ +SDVWS+GV +WE ++G KPY G+ E+ +LEKGER+ P C Sbjct: 185 WMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPIC 244 Query: 598 PREMYDLMNLCWTYDVENRPGFAAVELRLR 627 ++Y +M CW D ++RP F + Sbjct: 245 TIDVYMVMVKCWMIDADSRPKFKELAAEFS 274 >5U6B-A nrPDB Length = 307 Score = 291 bits (744), Expect = 8e-79, Method: Composition-based stats. Identities = 99/285 (34%), Positives = 159/285 (55%), Gaps = 15/285 (5%) Query: 357 EIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE 416 + + ++V +DR + L K LG G FG V +G + VAVK +K + ++ Sbjct: 12 KEKLRDVMVDRHKVAL-GKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELED 70 Query: 417 LLAEANVMQQLDNPYIVRMIGIC----EAESW---MLVMEMAELGPLNKYL------QQN 463 L+EA M++ D+P ++R+IG+C E ES+ ++++ + G L+ +L Q Sbjct: 71 FLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQP 130 Query: 464 RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADE 523 ++ + +++ + ++ GM+YL F+HRDLAARN +L ++DFGLSK + Sbjct: 131 VYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNG- 189 Query: 524 NYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTA 583 +YY+ K PVKW A E + ++SKSDVWSFGV MWE + GQ PY G++ SE+ Sbjct: 190 DYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYD 249 Query: 584 MLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 L +G R+ PA C +Y LM+ CW + ++RP F + L N Sbjct: 250 YLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLEN 294 >1U54-B nrPDB Length = 291 Score = 290 bits (742), Expect = 1e-78, Method: Composition-based stats. Identities = 105/266 (39%), Positives = 155/266 (58%), Gaps = 5/266 (1%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQM-KKVVKTVAVKILKNEA-NDPALKDELLAEAN 422 + K L L +K LG G+FG V++G + +VAVK LK + + P D+ + E N Sbjct: 15 IGEKDLRLLEK-LGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVN 73 Query: 423 VMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQN-RHVKDKNIIELVHQVSMG 481 M LD+ ++R+ G+ +V E+A LG L L+++ H + QV+ G Sbjct: 74 AMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEG 133 Query: 482 MKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 541 M YLE F+HRDLAARN+LL T+ KI DFGL +AL ++++Y Q H K P W AP Sbjct: 134 MGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAP 193 Query: 542 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK-GERMGCPAGCPRE 600 E + FS SD W FGV +WE F+YGQ+P+ G+ GS++ ++K GER+ P CP++ Sbjct: 194 ESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 253 Query: 601 MYDLMNLCWTYDVENRPGFAAVELRL 626 +Y++M CW + E+RP F A+ L Sbjct: 254 IYNVMVQCWAHKPEDRPTFVALRDFL 279 >5AMN-A nrPDB Length = 299 Score = 290 bits (742), Expect = 2e-78, Method: Composition-based stats. Identities = 110/302 (36%), Positives = 170/302 (56%), Gaps = 24/302 (7%) Query: 340 ALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKG---YYQMKKVV 396 L + + ++ DP+ P RK L L K LG G FG V K + + + Sbjct: 2 PLSLSVDAFK-ILEDPKWEFP------RKNLVL-GKTLGEGEFGKVVKATAFHLKGRAGY 53 Query: 397 KTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAE-SWMLVMEMAELGP 455 TVAVK+LK A+ L+D LL+E NV++Q+++P+++++ G C + +L++E A+ G Sbjct: 54 TTVAVKMLKENASPSELRD-LLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGS 112 Query: 456 LNKYLQQNRH----------VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQ 505 L +L+++R + ++I Q+S GM+YL E VHRDLAARN+L+ Sbjct: 113 LRGFLRESRKVGPGYPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEG 172 Query: 506 HYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEA 565 KISDFGLS+ + +E+ Y ++ G+ PVKW A E + + ++++SDVWSFGVL+WE Sbjct: 173 RKMKISDFGLSRDVY-EEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEI 231 Query: 566 FSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELR 625 + G PY G+ + +L+ G RM P C EMY LM CW + + RP FA + Sbjct: 232 VTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKD 291 Query: 626 LR 627 L Sbjct: 292 LE 293 >4K33-A nrPDB Length = 325 Score = 290 bits (742), Expect = 2e-78, Method: Composition-based stats. Identities = 107/298 (35%), Positives = 159/298 (53%), Gaps = 32/298 (10%) Query: 353 ADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKK----GYYQMKKVV-KTVAVKILKNE 407 ADP+ L R LTL K LG G FG V G + + TVAVK+LK++ Sbjct: 27 ADPKW------ELSRARLTL-GKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDD 79 Query: 408 ANDPALKDELLAEANVMQQL-DNPYIVRMIGICEAESWMLVM-EMAELGPLNKYLQQNRH 465 A D L D L++E +M+ + + I+ ++G C + V+ E A G L ++L+ R Sbjct: 80 ATDKDLSD-LVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRP 138 Query: 466 ----------------VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAK 509 + K+++ +QV+ GM+YL +HRDLAARNVL+ + K Sbjct: 139 PGLDYSFDTSKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMK 198 Query: 510 ISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYG 569 I+DFGL++ + +YYK T+G+ PVKW APE + ++ +SDVWSFGVL+WE F+ G Sbjct: 199 IADFGLARDVHN-LDYYKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLG 257 Query: 570 QKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 PY G+ E+ +L++G RM PA C ++Y +M CW RP F + L Sbjct: 258 GSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLD 315 >5A46-A nrPDB Length = 386 Score = 289 bits (741), Expect = 2e-78, Method: Composition-based stats. Identities = 109/301 (36%), Positives = 161/301 (53%), Gaps = 29/301 (9%) Query: 350 SPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKK----GYYQMK-KVVKTVAVKIL 404 S Y PE+ R L R L L K LG G FG V G + K V VAVK+L Sbjct: 25 SEYELPEDPR---WELPRDRLVL-GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML 80 Query: 405 KNEANDPALKDELLAEANVMQQL-DNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQ 462 K++A + L D L++E +M+ + + I+ ++G C + +++E A G L +YLQ Sbjct: 81 KSDATEKDLSD-LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQA 139 Query: 463 NRH----------------VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQH 506 R + K+++ +QV+ GM+YL +HRDLAARNVL+ + Sbjct: 140 RRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN 199 Query: 507 YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAF 566 KI+DFGL++ + +YYK T+G+ PVKW APE + ++ +SDVWSFGVL+WE F Sbjct: 200 VMKIADFGLARDIHH-IDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIF 258 Query: 567 SYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 626 + G PY G+ E+ +L++G RM P+ C E+Y +M CW RP F + L Sbjct: 259 TLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 318 Query: 627 R 627 Sbjct: 319 D 319 >3V5Q-A nrPDB Length = 297 Score = 289 bits (740), Expect = 2e-78, Method: Composition-based stats. Identities = 91/286 (31%), Positives = 150/286 (52%), Gaps = 24/286 (8%) Query: 364 YLDRKLLTLEDKELGSGNFGTVKKGYY---QMKKVVKTVAVKILKNEANDPALKDELLAE 420 ++ R+ + L+ +ELG G FG V K VAVK LK+ A + + E Sbjct: 11 HIKRRDIVLK-RELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTL--AARKDFQRE 67 Query: 421 ANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRH-------------- 465 A ++ L + +IV+ G+C + + ++V E + G LNK+L+ + Sbjct: 68 AELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAK 127 Query: 466 --VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADE 523 + ++ + Q++ GM YL +FVHRDLA RN L+ KI DFG+S+ + + Sbjct: 128 GELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYS-T 186 Query: 524 NYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTA 583 +YY+ H P++W PE I Y KF+++SDVWSFGV++WE F+YG++P+ + +EV Sbjct: 187 DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIE 246 Query: 584 MLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNY 629 + +G + P CP+E+YD+M CW + + R + L Sbjct: 247 CITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHAL 292 >4XCU-A nrPDB Length = 300 Score = 288 bits (737), Expect = 5e-78, Method: Composition-based stats. Identities = 102/279 (36%), Positives = 152/279 (54%), Gaps = 17/279 (6%) Query: 363 VYLDRKLLTLEDKELGSGNFGTVKKGYY-----QMKKVVKTVAVKILKNEANDPALKDEL 417 R L L K LG G FG V + TVAVK+LK+ A+D L D L Sbjct: 12 WEFPRDRLVL-GKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLAD-L 69 Query: 418 LAEANVMQQL-DNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQNRH-------VKD 468 ++E VM+ + + I+ ++G+C E +++E A G L ++L+ R + Sbjct: 70 VSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSF 129 Query: 469 KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKA 528 ++ +QV+ GM+YLE +HRDLAARNVL+ + KI+DFGL++ + +YYK Sbjct: 130 PVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHH-IDYYKK 188 Query: 529 QTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG 588 ++G+ PVKW APE + ++ +SDVWSFG+L+WE F+ G PY G+ E+ ++L +G Sbjct: 189 TSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREG 248 Query: 589 ERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 RM P CP E+Y LM CW RP F + L Sbjct: 249 HRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALD 287 >5EG3-A nrPDB Length = 334 Score = 286 bits (733), Expect = 1e-77, Method: Composition-based stats. Identities = 105/301 (34%), Positives = 162/301 (53%), Gaps = 29/301 (9%) Query: 350 SPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKK----GYYQMK-KVVKTVAVKIL 404 S + PE+ + R LTL K LG G FG V G + K K TVAVK+L Sbjct: 20 SEFELPEDPK---WEFPRDKLTL-GKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKML 75 Query: 405 KNEANDPALKDELLAEANVMQQL-DNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQ 462 K++A + L D L++E +M+ + + I+ ++G C + +++ A G L +YL+ Sbjct: 76 KDDATEKDLSD-LVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRA 134 Query: 463 NRH----------------VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQH 506 R + K+++ +Q++ GM+YL +HRDLAARNVL+ + Sbjct: 135 RRPPGMELSPDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENN 194 Query: 507 YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAF 566 KI+DFGL++ + + +++K T+G+ PVKW APE + ++ +SDVWSFGVLMWE F Sbjct: 195 VMKIADFGLARDI-NNIDFFKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIF 253 Query: 567 SYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 626 + G PY G+ E+ +L++G RM PA C E+Y +M CW RP F + L Sbjct: 254 TLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 313 Query: 627 R 627 Sbjct: 314 D 314 >3PP0-A nrPDB Length = 338 Score = 286 bits (731), Expect = 2e-77, Method: Composition-based stats. Identities = 105/256 (41%), Positives = 154/256 (60%), Gaps = 5/256 (1%) Query: 375 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 K LGSG FGTV KG + + V VA+K+L+ E P E+L EA VM + +PY+ Sbjct: 23 KVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLR-ENTSPKANKEILDEAYVMAGVGSPYV 81 Query: 433 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 491 R++GIC + LV ++ G L ++++NR + ++++ Q++ GM YLE+ V Sbjct: 82 SRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLV 141 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 HRDLAARNVL+ + ++ KI+DFGL++ L DE Y A GK P+KW A E I +F+ Sbjct: 142 HRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHAD-GGKVPIKWMALESILRRRFTH 200 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 611 +SDVWS+GV +WE ++G KPY G+ E+ +LEKGER+ P C ++Y +M CW Sbjct: 201 QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMI 260 Query: 612 DVENRPGFAAVELRLR 627 D E RP F + Sbjct: 261 DSECRPRFRELVSEFS 276 >5GNK-A nrPDB Length = 297 Score = 286 bits (731), Expect = 3e-77, Method: Composition-based stats. Identities = 108/256 (42%), Positives = 164/256 (64%), Gaps = 5/256 (1%) Query: 375 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 K LGSG FGTV KG + + +KV VA+K L+ EA P E+L EA VM +DNP++ Sbjct: 25 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATSPKANKEILDEAYVMASVDNPHV 83 Query: 433 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 491 R++GIC + L+M++ G L Y+++++ ++ + ++ Q++ GM YLE+ V Sbjct: 84 CRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLV 143 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 HRDLAARNVL+ T + KI+DFGL+K L A+E Y A+ GK P+KW A E I + ++ Sbjct: 144 HRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAE-GGKVPIKWMALESILHRIYTH 202 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 611 +SDVWS+GV +WE ++G KPY G+ SE++++LEKGER+ P C ++Y +M CW Sbjct: 203 QSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMI 262 Query: 612 DVENRPGFAAVELRLR 627 D ++RP F + + Sbjct: 263 DADSRPKFRELIIEFS 278 >3CJF-A nrPDB Length = 309 Score = 285 bits (729), Expect = 5e-77, Method: Composition-based stats. Identities = 102/310 (32%), Positives = 154/310 (49%), Gaps = 28/310 (9%) Query: 339 EALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYY---QMKKV 395 + LP+D PY + P+ DR L K LG G FG V + Sbjct: 4 DELPLDEHCERLPYDASKWEFPR----DRLNL---GKPLGRGAFGQVIEADAFGIDKTAT 56 Query: 396 VKTVAVKILKNEANDPALKDELLAEANVMQQLDNP-YIVRMIGICEAE--SWMLVMEMAE 452 +TVAVK+LK A + L++E ++ + + +V ++G C M+++E + Sbjct: 57 CRTVAVKMLKEGATHSEHR-ALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCK 115 Query: 453 LGPLNKYLQQNRH------------VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNV 500 G L+ YL+ R+ + +++I QV+ GM++L +HRDLAARN+ Sbjct: 116 FGNLSTYLRSKRNEFVPYKDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNI 175 Query: 501 LLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGV 560 LL ++ KI DFGL++ + D +Y + + P+KW APE I ++ +SDVWSFGV Sbjct: 176 LLSEKNVVKICDFGLARDIYKDPDYVRKG-DARLPLKWMAPETIFDRVYTIQSDVWSFGV 234 Query: 561 LMWEAFSYGQKPYRGMK-GSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGF 619 L+WE FS G PY G+K E L++G RM P EMY M CW + RP F Sbjct: 235 LLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTF 294 Query: 620 AAVELRLRNY 629 + + L N Sbjct: 295 SELVEHLGNL 304 >3LZB-A nrPDB Length = 327 Score = 284 bits (728), Expect = 5e-77, Method: Composition-based stats. Identities = 107/256 (41%), Positives = 163/256 (63%), Gaps = 5/256 (1%) Query: 375 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 K LGSG FGTV KG + + +KV VA+K L+ EA P E+L EA VM +DNP++ Sbjct: 21 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATSPKANKEILDEAYVMASVDNPHV 79 Query: 433 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 491 R++GIC + L+ ++ G L Y+++++ ++ + ++ Q++ GM YLE+ V Sbjct: 80 CRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLV 139 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 HRDLAARNVL+ T + KI+DFGL+K L A+E Y A+ GK P+KW A E I + ++ Sbjct: 140 HRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAE-GGKVPIKWMALESILHRIYTH 198 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 611 +SDVWS+GV +WE ++G KPY G+ SE++++LEKGER+ P C ++Y +M CW Sbjct: 199 QSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMI 258 Query: 612 DVENRPGFAAVELRLR 627 D ++RP F + + Sbjct: 259 DADSRPKFRELIIEFS 274 >4OLI-A nrPDB Length = 645 Score = 284 bits (727), Expect = 8e-77, Method: Composition-based stats. Identities = 113/351 (32%), Positives = 162/351 (46%), Gaps = 35/351 (9%) Query: 303 HRKSSPAQGNRQESTVSFNPYEPELAPWA---ADKGPQREA---LPMDTEVYESPYADPE 356 HR P+ T YEP P + + + T +SP +DP Sbjct: 289 HRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPT 348 Query: 357 EIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKK--VVKTVAVKILKNEANDPALK 414 V+ R L + D LG G+FG V Y + VAVK LK + P + Sbjct: 349 ------VFHKRYLKKIRD--LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCG-PQHR 399 Query: 415 DELLAEANVMQQLDNPYIVRMIGICEAES---WMLVMEMAELGPLNKYLQQNRHVKDKNI 471 E ++++ L + +I++ G CE + LVME LG L YL ++ + + Sbjct: 400 SGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRH-SIGLAQL 458 Query: 472 IELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTH 531 + Q+ GM YL +++HR+LAARNVLL KI DFGL+KA+ YY+ + Sbjct: 459 LLFAQQICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVRED 518 Query: 532 GKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYG----QKPYR----------GMK 577 G PV WYAPEC+ YKF SDVWSFGV ++E ++ P + M Sbjct: 519 GDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMT 578 Query: 578 GSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 +T +LE+GER+ P CP E+Y LM CW + RP F + L+ Sbjct: 579 VLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKT 629 Score = 162 bits (410), Expect = 4e-40, Method: Composition-based stats. Identities = 74/315 (23%), Positives = 129/315 (40%), Gaps = 48/315 (15%) Query: 348 YESPYADPEEIRPKEVYLDRKLLTLEDKE--LGSGNFGTVKKGYYQMKKVVK-------- 397 ++ A P + ++ R + LG G V +G +++ Sbjct: 22 FQGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDD 81 Query: 398 --------------TVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC-EAE 442 V +K+L +D AL A++M Q+ + ++ + G+C Sbjct: 82 EDPLVPGRDRGQELRVVLKVLDPSHHDIALA--FYETASLMSQVSHTHLAFVHGVCVRGP 139 Query: 443 SWMLVMEMAELGPLNKYLQQ-NRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVL 501 ++V E E GPL+ +L++ HV + + Q++ + YLE N VH ++ RN+L Sbjct: 140 ENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNIL 199 Query: 502 LV-------TQHYAKISDFGLS-KALRADENYYKAQTHGKWPVKWYAPECI--NYYKFSS 551 L T + K+SD G+ AL +E + + W APEC+ S+ Sbjct: 200 LARLGLAEGTSPFIKLSDPGVGLGALSREERVER--------IPWLAPECLPGGANSLST 251 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 611 D W FG + E G+ P + SE ++ R+ P+ CP+ + L + C TY Sbjct: 252 AMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPS-CPQ-LATLTSQCLTY 309 Query: 612 DVENRPGFAAVELRL 626 + RP F + L Sbjct: 310 EPTQRPSFRTILRDL 324 >5U6C-A nrPDB Length = 315 Score = 283 bits (724), Expect = 2e-76, Method: Composition-based stats. Identities = 101/300 (33%), Positives = 162/300 (54%), Gaps = 17/300 (5%) Query: 351 PYADPEEIRPK--EVYLDRKLLTLEDKELGSGNFGTVKKG-YYQMKKVVKTVAVKILKNE 407 + EE++ K +V +DR LL L K LG G FG+V +G Q VAVK +K + Sbjct: 17 YFQGSEELQNKLEDVVIDRNLLIL-GKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLD 75 Query: 408 ANDPALKDELLAEANVMQQLDNPYIVRMIGICEA------ESWMLVMEMAELGPLNKYL- 460 + +E L+EA M+ +P ++R++G+C M+++ + G L+ YL Sbjct: 76 NSSQREIEEFLSEAACMKDFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLL 135 Query: 461 -----QQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGL 515 +H+ + +++ + +++GM+YL NF+HRDLAARN +L ++DFGL Sbjct: 136 YSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGL 195 Query: 516 SKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG 575 SK + + +YY+ K PVKW A E + ++SKSDVW+FGV MWE + G PY G Sbjct: 196 SKKIYSG-DYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPG 254 Query: 576 MKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 ++ E+ L G R+ P C E+Y++M CW D +RP F+ + L+L + + Sbjct: 255 VQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPD 314 >1K9A-A nrPDB Length = 450 Score = 283 bits (724), Expect = 2e-76, Method: Composition-based stats. Identities = 112/290 (38%), Positives = 159/290 (54%), Gaps = 19/290 (6%) Query: 343 MDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVK 402 + +V E A +E L+ K L L + +G G FG V G Y+ K VAVK Sbjct: 168 IKPKVMEGTVAAQDEFYRSGWALNMKELKLL-QTIGKGEFGDVMLGDYRGNK----VAVK 222 Query: 403 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC--EAESWMLVMEMAELGPLNKYL 460 +KN+A LAEA+VM QL + +V+++G+ E +V E G L YL Sbjct: 223 CIKNDAT----AQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYL 278 Query: 461 QQNRH--VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKA 518 + + +++ V M+YLE +NFVHRDLAARNVL+ + AK+SDFGL+K Sbjct: 279 RSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE 338 Query: 519 LRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKG 578 + ++ GK PVKW APE + KFS+KSDVWSFG+L+WE +S+G+ PY + Sbjct: 339 ASSTQD------TGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPL 392 Query: 579 SEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 +V +EKG +M P GCP +YD+M CW D RP F + +L + Sbjct: 393 KDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 Score = 132 bits (331), Expect = 6e-31, Method: Composition-based stats. Identities = 61/326 (18%), Positives = 109/326 (33%), Gaps = 52/326 (15%) Query: 13 LPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNG 72 +P+F G ITRE+AE L GL+L+R+S NY G + L V+ K HY I + Sbjct: 80 MPWFHGKITREQAERLLYPP--ETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHAS- 136 Query: 73 TYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFED---------- 122 +I + L +++ ++DGL L KP V + + Sbjct: 137 KLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELK 196 Query: 123 LKENLIREYVKQTWNLQGQALEQAIISQKP--------QLEKLIATTAHEKMPWFHGKIS 174 L + + + + + A+ K ++ H + G I Sbjct: 197 LLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIV 256 Query: 175 REESEQIVLIGSKTNGKFL--IRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGK 232 E+ ++ G + +R+R +L +L + +D + + Sbjct: 257 EEKGGLYIVTEYMAKGSLVDYLRSRGR------SVLGGDCLLKFSLDVCEAMEYLEGNNF 310 Query: 233 KFDTLWQ---LVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPA------- 282 L LV D + +V K + G+ + + P Sbjct: 311 VHRDLAARNVLVS-----EDNVAKVSDFGLTKEASS--TQDTGKLPVKWTAPEALREKKF 363 Query: 283 -----TWSAGGIISRIKSYS-FPKPG 302 WS G ++ I S+ P P Sbjct: 364 STKSDVWSFGILLWEIYSFGRVPYPR 389 Score = 128 bits (321), Expect = 9e-30, Method: Composition-based stats. Identities = 54/132 (40%), Positives = 71/132 (53%), Gaps = 6/132 (4%) Query: 136 WNLQGQALEQAIISQK--PQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFL 193 + + + + II + E + A T MPWFHGKI+RE++E+++ G FL Sbjct: 48 YKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLY--PPETGLFL 105 Query: 194 IRARDN-NGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLL 252 +R N G Y LC+ EGKV HYRI + KLSI E F+ L QLVEHY+ ADGL Sbjct: 106 VRESTNYPGDYTLCVSCEGKVEHYRIMYHAS-KLSIDEEVYFENLMQLVEHYTTDADGLC 164 Query: 253 RVLTVPCQKIGT 264 L P GT Sbjct: 165 TRLIKPKVMEGT 176 >3QUP-A nrPDB Length = 323 Score = 283 bits (724), Expect = 2e-76, Method: Composition-based stats. Identities = 93/290 (32%), Positives = 157/290 (54%), Gaps = 16/290 (5%) Query: 353 ADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKG-YYQMKKVVKTVAVKILKNEANDP 411 +D + + ++V + + TL + LG G FG+V++ Q VAVK+LK + Sbjct: 8 SDELKEKLEDVLIPEQQFTL-GRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIAS 66 Query: 412 ALKDELLAEANVMQQLDNPYIVRMIGICEAES-------WMLVMEMAELGPLNKYLQQNR 464 + +E L EA M++ D+P++ +++G+ M+++ + G L+ +L +R Sbjct: 67 SDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASR 126 Query: 465 ------HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKA 518 ++ + ++ + ++ GM+YL NF+HRDLAARN +L ++DFGLS+ Sbjct: 127 IGENPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRK 186 Query: 519 LRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKG 578 + + +YY+ K PVKW A E + ++ SDVW+FGV MWE + GQ PY G++ Sbjct: 187 IYSG-DYYRQGCASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIEN 245 Query: 579 SEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 +E+ L G R+ P C E+YDLM CW+ D + RP F + + L N Sbjct: 246 AEIYNYLIGGNRLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELEN 295 >1BYG-A nrPDB Length = 278 Score = 282 bits (722), Expect = 3e-76, Method: Composition-based stats. Identities = 107/270 (39%), Positives = 152/270 (56%), Gaps = 19/270 (7%) Query: 363 VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEAN 422 L+ K L L + +G G FG V G Y+ K VAVK +KN+A LAEA+ Sbjct: 16 WALNMKELKLL-QTIGKGEFGDVMLGDYRGNK----VAVKCIKNDAT----AQAFLAEAS 66 Query: 423 VMQQLDNPYIVRMIGIC--EAESWMLVMEMAELGPLNKYLQQNRH--VKDKNIIELVHQV 478 VM QL + +V+++G+ E +V E G L YL+ + +++ V Sbjct: 67 VMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 126 Query: 479 SMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKW 538 M+YLE +NFVHRDLAARNVL+ + AK+SDFGL+K + ++ GK PVKW Sbjct: 127 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD------TGKLPVKW 180 Query: 539 YAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCP 598 APE + KFS+KSDVWSFG+L+WE +S+G+ PY + +V +EKG +M P GCP Sbjct: 181 TAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP 240 Query: 599 REMYDLMNLCWTYDVENRPGFAAVELRLRN 628 +Y++M CW D RP F + +L + Sbjct: 241 PAVYEVMKNCWHLDAAMRPSFLQLREQLEH 270 >5FM2-A nrPDB Length = 355 Score = 282 bits (722), Expect = 3e-76, Method: Composition-based stats. Identities = 113/339 (33%), Positives = 178/339 (52%), Gaps = 35/339 (10%) Query: 318 VSFNPYEPELAPWAADKGPQREAL-PMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKE 376 ++F + G +R +L M+ +V + E+ + RK L L K Sbjct: 16 MTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPK---WEFPRKNLVL-GKT 71 Query: 377 LGSGNFGTVKKG---YYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 LG G FG V K + + + TVAVK+LK A+ L+D LL+E NV++Q+++P+++ Sbjct: 72 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRD-LLSEFNVLKQVNHPHVI 130 Query: 434 RMIGICEAE-SWMLVMEMAELGPLNKYLQQNRH------------------------VKD 468 ++ G C + +L++E A+ G L +L+++R + Sbjct: 131 KLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTM 190 Query: 469 KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKA 528 ++I Q+S GM+YL E VHRDLAARN+L+ KISDFGLS+ + +E+ Y Sbjct: 191 GDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVY-EEDSYVK 249 Query: 529 QTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG 588 ++ G+ PVKW A E + + ++++SDVWSFGVL+WE + G PY G+ + +L+ G Sbjct: 250 RSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTG 309 Query: 589 ERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 RM P C EMY LM CW + + RP FA + L Sbjct: 310 HRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLE 348 >1FVR-A nrPDB Length = 327 Score = 282 bits (721), Expect = 3e-76, Method: Composition-based stats. Identities = 97/281 (34%), Positives = 147/281 (52%), Gaps = 24/281 (8%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424 LD + +D +G GNFG V K + + A+K +K A+ +D E V+ Sbjct: 22 LDWNDIKFQD-VIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRD-FAGELEVL 79 Query: 425 QQL-DNPYIVRMIGICEAESW-MLVMEMAELGPLNKYLQQNR----------------HV 466 +L +P I+ ++G CE + L +E A G L +L+++R + Sbjct: 80 CKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTL 139 Query: 467 KDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYY 526 + ++ V+ GM YL + F+HRDLAARN+L+ + AKI+DFGLS+ + Y Sbjct: 140 SSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSR----GQEVY 195 Query: 527 KAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLE 586 +T G+ PV+W A E +NY +++ SDVWS+GVL+WE S G PY GM +E+ L Sbjct: 196 VKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLP 255 Query: 587 KGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 +G R+ P C E+YDLM CW RP FA + + L Sbjct: 256 QGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLN 296 >5H2U-A nrPDB Length = 267 Score = 281 bits (719), Expect = 6e-76, Method: Composition-based stats. Identities = 93/270 (34%), Positives = 152/270 (56%), Gaps = 12/270 (4%) Query: 363 VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEAN 422 + R+ TL ++LGSG FG V +G ++ + VA+K++ + + + L +E Sbjct: 1 MERPREEFTLC-RKLGSGYFGEVFEGLWKDR---VQVAIKVISRD--NLLHQQMLQSEIQ 54 Query: 423 VMQQLDNPYIVRMIGICE-AESWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVS 479 M++L + +I+ + + + ++ E+ G L + L+ + + ++++ QV+ Sbjct: 55 AMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVA 114 Query: 480 MGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY 539 GM YLE N++HRDLAARN+L+ K+ DFGL++ ++ E+ Y + H P KW Sbjct: 115 EGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIK--EDVYLSHDHN-IPYKWT 171 Query: 540 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR 599 APE ++ +S+KSDVWSFG+L+ E FS GQ PY GM E ++ G RM CP CP Sbjct: 172 APEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPP 231 Query: 600 EMYDLMNLCWTYDVENRPGFAAVELRLRNY 629 ++ LM CW D E RP F A+ RL ++ Sbjct: 232 SVHKLMLTCWCRDPEQRPTFKALRERLSSF 261 >3QGY-A nrPDB Length = 286 Score = 280 bits (717), Expect = 1e-75, Method: Composition-based stats. Identities = 103/267 (38%), Positives = 151/267 (56%), Gaps = 11/267 (4%) Query: 362 EVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEA 421 + +D LT +E+GSG FG V GY+ K VA+K +K + D+ + EA Sbjct: 21 HMVIDPSELTF-VQEIGSGQFGLVHLGYWLNKD---KVAIKTIKEGSMSE---DDFIEEA 73 Query: 422 NVMQQLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQ-QNRHVKDKNIIELVHQVS 479 VM +L +P +V++ G+C + LV E E G L+ YL+ Q + ++ + V Sbjct: 74 EVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVC 133 Query: 480 MGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY 539 GM YLEE+ +HRDLAARN L+ K+SDFG+++ + D+ Y + T K+PVKW Sbjct: 134 EGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQ--YTSSTGTKFPVKWA 191 Query: 540 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR 599 +PE ++ ++SSKSDVWSFGVLMWE FS G+ PY SEV + G R+ P Sbjct: 192 SPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLAST 251 Query: 600 EMYDLMNLCWTYDVENRPGFAAVELRL 626 +Y +MN CW E+RP F+ + +L Sbjct: 252 HVYQIMNHCWKERPEDRPAFSRLLRQL 278 >3ZBF-A nrPDB Length = 322 Score = 279 bits (715), Expect = 2e-75, Method: Composition-based stats. Identities = 98/290 (33%), Positives = 159/290 (54%), Gaps = 23/290 (7%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKG----YYQMKKVVKTVAVKILKNEANDPALKDELLAE 420 R+ LTL LGSG FG V +G + VAVK LK + D K E L E Sbjct: 30 FPREKLTLRL-LLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQE-KIEFLKE 87 Query: 421 ANVMQQLDNPYIVRMIGICE-AESWMLVMEMAELGPLNKYLQQNRHVK-------DKNII 472 A++M + ++P I++ +G+C E +++E+ E G L YL++ R +++ Sbjct: 88 AHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLV 147 Query: 473 ELVHQVSMGMKYLEESNFVHRDLAARNVLL-----VTQHYAKISDFGLSKALRADENYYK 527 +L +S G YLE +F+HRDLAARN L+ + KI DFGL++ + + +YY+ Sbjct: 148 DLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKN-DYYR 206 Query: 528 AQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 + G PV+W APE + F+++SDVWSFG+L+WE + G +PY +V ++ Sbjct: 207 KRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQT 266 Query: 588 GERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL---RNYYYDVV 634 G R+ P CP ++++LM CW + + RP F ++ +L RN++ + + Sbjct: 267 GGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSI 316 >6DBM-A nrPDB Length = 318 Score = 279 bits (714), Expect = 2e-75, Method: Composition-based stats. Identities = 102/285 (35%), Positives = 143/285 (50%), Gaps = 23/285 (8%) Query: 363 VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKK--VVKTVAVKILKNEANDPALKDELLAE 420 V+ R L + D LG G+FG V Y + VAVK LK +A P + E Sbjct: 27 VFHKRYLKKIRD--LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAG-PQHRSGWKQE 83 Query: 421 ANVMQQLDNPYIVRMIGICEAES---WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQ 477 ++++ L + +I++ G CE LVME LG L YL ++ + ++ Q Sbjct: 84 IDILRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRH-SIGLAQLLLFAQQ 142 Query: 478 VSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVK 537 + GM YL +++HRDLAARNVLL KI DFGL+KA+ YY+ + G PV Sbjct: 143 ICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVF 202 Query: 538 WYAPECINYYKFSSKSDVWSFGVLMWEAFSYG----QKPYR----------GMKGSEVTA 583 WYAPEC+ YKF SDVWSFGV ++E ++ P + M +T Sbjct: 203 WYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTE 262 Query: 584 MLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 +LE+GER+ P CP E+Y LM CW + RP F + L+ Sbjct: 263 LLERGERLPRPDKCPAEVYHLMKNCWETEASFRPTFENLIPILKT 307 >2OGV-A nrPDB Length = 317 Score = 279 bits (714), Expect = 3e-75, Method: Composition-based stats. Identities = 99/294 (33%), Positives = 155/294 (52%), Gaps = 20/294 (6%) Query: 352 YADPEEIR-PKEVYLDRKLLTLEDKELGSGNFGTVKKGY---YQMKKVVKTVAVKILKNE 407 + DP ++ ++ R L K LG+G FG V + + V VAVK+LK+ Sbjct: 21 FIDPTQLPYNEKWEFPRNNLQF-GKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKST 79 Query: 408 ANDPALKDELLAEANVMQQL-DNPYIVRMIGICEAESWMLV-MEMAELGPLNKYLQQN-- 463 A K+ L++E +M L + IV ++G C +LV E G L +L++ Sbjct: 80 A-HADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAE 138 Query: 464 --------RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGL 515 R ++ ++++ QV+ GM +L N +HRD+AARNVLL H AKI DFGL Sbjct: 139 ADLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGL 198 Query: 516 SKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG 575 ++ + D NY + + + PVKW APE I ++ +SDVWS+G+L+WE FS G PY G Sbjct: 199 ARDIMNDSNYI-VKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPG 257 Query: 576 -MKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 + S+ +++ G +M PA P+ +Y +M CW + +RP F + L+ Sbjct: 258 ILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQE 311 >1LUF-A nrPDB Length = 343 Score = 279 bits (713), Expect = 3e-75, Method: Composition-based stats. Identities = 97/281 (34%), Positives = 149/281 (53%), Gaps = 30/281 (10%) Query: 375 KELGSGNFGTVKKGY---YQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPY 431 +++G G FG V + + VAVK+LK EA ++ + EA +M + DNP Sbjct: 53 RDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEA-SADMQADFQREAALMAEFDNPN 111 Query: 432 IVRMIGICE-AESWMLVMEMAELGPLNKYLQQ------------------------NRHV 466 IV+++G+C + L+ E G LN++L+ + Sbjct: 112 IVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPPL 171 Query: 467 KDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYY 526 + + QV+ GM YL E FVHRDLA RN L+ KI+DFGLS+ + + +YY Sbjct: 172 SCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYS-ADYY 230 Query: 527 KAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLE 586 KA + P++W PE I Y +++++SDVW++GV++WE FSYG +PY GM EV + Sbjct: 231 KADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVR 290 Query: 587 KGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 G + CP CP E+Y+LM LCW+ +RP F ++ L+ Sbjct: 291 DGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRILQ 331 >3C1X-A nrPDB Length = 373 Score = 278 bits (711), Expect = 5e-75, Method: Composition-based stats. Identities = 92/270 (34%), Positives = 142/270 (52%), Gaps = 6/270 (2%) Query: 366 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKT-VAVKILKNEANDPALKDELLAEANVM 424 L+ ++ +G G+FG V G K AVK L N D + L E +M Sbjct: 86 PSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSL-NRITDIGEVSQFLTEGIIM 144 Query: 425 QQLDNPYIVRMIGIC--EAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMG 481 + +P ++ ++GIC S ++V+ + G L +++ H K++I QV+ G Sbjct: 145 KDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKG 204 Query: 482 MKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADE-NYYKAQTHGKWPVKWYA 540 MK+L FVHRDLAARN +L + K++DFGL++ + E + +T K PVKW A Sbjct: 205 MKFLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMA 264 Query: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600 E + KF++KSDVWSFGVL+WE + G PY + ++T L +G R+ P CP Sbjct: 265 LESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDP 324 Query: 601 MYDLMNLCWTYDVENRPGFAAVELRLRNYY 630 +Y++M CW E RP F+ + R+ + Sbjct: 325 LYEVMLKCWHPKAEMRPSFSELVSRISAIF 354 >5HLW-A nrPDB Length = 299 Score = 278 bits (710), Expect = 7e-75, Method: Composition-based stats. Identities = 94/270 (34%), Positives = 142/270 (52%), Gaps = 6/270 (2%) Query: 366 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKT-VAVKILKNEANDPALKDELLAEANVM 424 L+ ++ +G G+FG V G K AVK L N D + L E +M Sbjct: 17 PSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSL-NRITDIGEVSQFLTEGIIM 75 Query: 425 QQLDNPYIVRMIGIC--EAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMG 481 + +P ++ ++GIC S ++V+ + G L +++ H K++I QV+ G Sbjct: 76 KDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKG 135 Query: 482 MKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENY-YKAQTHGKWPVKWYA 540 MKYL FVHRDLAARN +L + K++DFGL++ + E Y +T K PVKW A Sbjct: 136 MKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMA 195 Query: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600 E + KF++KSDVWSFGVL+WE + G PY + ++T L +G R+ P CP Sbjct: 196 LESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDP 255 Query: 601 MYDLMNLCWTYDVENRPGFAAVELRLRNYY 630 +Y++M CW E RP F+ + R+ + Sbjct: 256 LYEVMLKCWHPKAEMRPSFSELVSRISAIF 285 >4LRM-A nrPDB Length = 334 Score = 278 bits (710), Expect = 8e-75, Method: Composition-based stats. Identities = 107/259 (41%), Positives = 163/259 (62%), Gaps = 8/259 (3%) Query: 375 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNP-- 430 K LGSG FGTV KG + + +KV VA+K L+ EA P E+L EA VM +DNP Sbjct: 25 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATSPKANKEILDEAYVMASVDNPGN 83 Query: 431 -YIVRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEES 488 ++ R++GIC + L+ ++ G L Y+++++ ++ + ++ Q++ GM YLE+ Sbjct: 84 PHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDR 143 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 VHRDLAARNVL+ T + KI+DFGL+K L A+E Y A+ GK P+KW A E I + Sbjct: 144 RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAE-GGKVPIKWMALESILHRI 202 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLC 608 ++ +SDVWS+GV +WE ++G KPY G+ SE++++LEKGER+ P C ++Y +M C Sbjct: 203 YTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKC 262 Query: 609 WTYDVENRPGFAAVELRLR 627 W D ++RP F + + Sbjct: 263 WMIDADSRPKFRELIIEFS 281 >4E20-A nrPDB Length = 290 Score = 277 bits (709), Expect = 9e-75, Method: Composition-based stats. Identities = 105/285 (36%), Positives = 142/285 (49%), Gaps = 23/285 (8%) Query: 363 VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKK--VVKTVAVKILKNEANDPALKDELLAE 420 V+ R L + D LG G+FG V Y + VAVK LK E P L+ E Sbjct: 4 VFHKRYLKKIRD--LGEGHFGKVSLYCYDPTNDGTGEMVAVKALK-EGCGPQLRSGWQRE 60 Query: 421 ANVMQQLDNPYIVRMIGICEAES---WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQ 477 +++ L + +IV+ G CE + LVME LG L YL ++ V ++ Q Sbjct: 61 IEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRH-CVGLAQLLLFAQQ 119 Query: 478 VSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVK 537 + GM YL +++HR LAARNVLL KI DFGL+KA+ YY+ + G PV Sbjct: 120 ICEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVF 179 Query: 538 WYAPECINYYKFSSKSDVWSFGVLMWEAFSYG---QKPYR-----------GMKGSEVTA 583 WYAPEC+ KF SDVWSFGV ++E +Y Q P+ M +T Sbjct: 180 WYAPECLKECKFYYASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVLRLTE 239 Query: 584 MLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 +LE+GER+ P CP E+Y LM CW + RP F + L+ Sbjct: 240 LLERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNLVPILQT 284 >5KMM-A nrPDB Length = 329 Score = 277 bits (709), Expect = 1e-74, Method: Composition-based stats. Identities = 89/285 (31%), Positives = 145/285 (50%), Gaps = 23/285 (8%) Query: 364 YLDRKLLTLEDKELGSGNFGTVKKGYYQM---KKVVKTVAVKILKNEANDPALKDELLAE 420 ++ R+ + L+ + LG G FG V ++ VAVK LK + + + E Sbjct: 31 HIKRRDIVLKWE-LGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASES--ARQDFQRE 87 Query: 421 ANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRH-------------- 465 A ++ L + +IVR G+C E ++V E G LN++L+ + Sbjct: 88 AELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG 147 Query: 466 -VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADEN 524 + ++ + QV+ GM YL +FVHRDLA RN L+ KI DFG+S+ + + + Sbjct: 148 PLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYS-TD 206 Query: 525 YYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAM 584 YY+ P++W PE I Y KF+++SDVWSFGV++WE F+YG++P+ + +E Sbjct: 207 YYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC 266 Query: 585 LEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNY 629 + +G + P CP E+Y +M CW + + R V RL+ Sbjct: 267 ITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQAL 311 >4Y93-A nrPDB Length = 446 Score = 277 bits (708), Expect = 1e-74, Method: Composition-based stats. Identities = 100/268 (37%), Positives = 150/268 (55%), Gaps = 11/268 (4%) Query: 363 VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEAN 422 +D K LT KELG+G FG VK G ++ + VA+K++K + DE + EA Sbjct: 183 WEIDPKDLTFL-KELGTGQFGVVKYGKWRGQY---DVAIKMIKEGSMSE---DEFIEEAK 235 Query: 423 VMQQLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSM 480 VM L + +V++ G+C + ++ E G L YL++ RH + + ++E+ V Sbjct: 236 VMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCE 295 Query: 481 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540 M+YLE F+HRDLAARN L+ Q K+SDFG+++ + DE Y + T K+PVKW + Sbjct: 296 AMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDE--YTSSTGSKFPVKWAS 353 Query: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600 PE + Y KFSSKSD+W+FGVLMWE +S G+ PY SE + +G R+ P Sbjct: 354 PEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLASER 413 Query: 601 MYDLMNLCWTYDVENRPGFAAVELRLRN 628 +Y +M CW + RP F + + + Sbjct: 414 VYAIMYSCWHEKADERPTFKILLSNILD 441 >3BEA-A nrPDB Length = 333 Score = 277 bits (708), Expect = 1e-74, Method: Composition-based stats. Identities = 99/298 (33%), Positives = 154/298 (51%), Gaps = 24/298 (8%) Query: 352 YADPEEIR-PKEVYLDRKLLTLEDKELGSGNFGTVKKGY---YQMKKVVKTVAVKILKNE 407 + DP ++ ++ R L K LG+G FG V + + V VAVK+LK+ Sbjct: 29 FIDPTQLPYNEKWEFPRNNLQF-GKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKST 87 Query: 408 ANDPALKDELLAEANVMQQL-DNPYIVRMIGICEAESWMLV-MEMAELGPLNKYLQQNRH 465 A K+ L++E +M L + IV ++G C +LV E G L +L++ Sbjct: 88 A-HADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSR 146 Query: 466 VKD--------------KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKIS 511 V + ++++ QV+ GM +L N +HRD+AARNVLL H AKI Sbjct: 147 VLETDPAFAIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIG 206 Query: 512 DFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQK 571 DFGL++ + D NY + + + PVKW APE I ++ +SDVWS+G+L+WE FS G Sbjct: 207 DFGLARDIMNDSNYI-VKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLN 265 Query: 572 PYRG-MKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 PY G + S+ +++ G +M PA P+ +Y +M CW + +RP F + L+ Sbjct: 266 PYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQE 323 >6E4F-A nrPDB Length = 290 Score = 277 bits (708), Expect = 1e-74, Method: Composition-based stats. Identities = 100/268 (37%), Positives = 149/268 (55%), Gaps = 11/268 (4%) Query: 363 VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEAN 422 +D K LT KELG+G FG VK G ++ + VA+K++K + DE + EA Sbjct: 26 WEIDPKDLTFL-KELGTGQFGVVKYGKWRGQY---DVAIKMIKEGSMSE---DEFIEEAK 78 Query: 423 VMQQLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSM 480 VM L + +V++ G+C + ++ E G L YL++ RH + + ++E+ V Sbjct: 79 VMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCE 138 Query: 481 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540 M+YLE F+HRDLAARN L+ Q K+SDFGLS+ + DE Y + K+PV+W Sbjct: 139 AMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDE--YTSSVGSKFPVRWSP 196 Query: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600 PE + Y KFSSKSD+W+FGVLMWE +S G+ PY SE + +G R+ P + Sbjct: 197 PEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEK 256 Query: 601 MYDLMNLCWTYDVENRPGFAAVELRLRN 628 +Y +M CW + RP F + + + Sbjct: 257 VYTIMYSCWHEKADERPTFKILLSNILD 284 >4XLV-A nrPDB Length = 328 Score = 277 bits (708), Expect = 1e-74, Method: Composition-based stats. Identities = 94/286 (32%), Positives = 156/286 (54%), Gaps = 17/286 (5%) Query: 360 PKEVYLDRKLLTLEDKELGSGNFGTVKKG--YYQMKKVVKT-VAVKILKNEANDPALKDE 416 P E + R+ +TL +ELG G+FG V +G +K +T VAVK + NE+ + E Sbjct: 31 PDEWEVSREKITLL-RELGQGSFGMVYEGNARDIIKGEAETRVAVKTV-NESASLRERIE 88 Query: 417 LLAEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQ----------NRH 465 L EA+VM+ ++VR++G+ + + ++VME+ G L YL+ Sbjct: 89 FLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPP 148 Query: 466 VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENY 525 + +I++ +++ GM YL FVHRDLAARN ++ KI DFG+++ + + +Y Sbjct: 149 PTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIY-ETDY 207 Query: 526 YKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAML 585 Y+ G PV+W APE + F++ SD+WSFGV++WE S ++PY+G+ +V + Sbjct: 208 YRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV 267 Query: 586 EKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYY 631 G + P CP + DLM +CW ++ RP F + L++ + Sbjct: 268 MDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLLKDDLH 313 >3SXS-A nrPDB Length = 268 Score = 276 bits (707), Expect = 1e-74, Method: Composition-based stats. Identities = 102/268 (38%), Positives = 150/268 (55%), Gaps = 11/268 (4%) Query: 362 EVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEA 421 + L R+ +TL KELGSG FG VK G ++ + VAVK++K + DE EA Sbjct: 2 HMELKREEITLL-KELGSGQFGVVKLGKWKGQY---DVAVKMIKEGSMSE---DEFFQEA 54 Query: 422 NVMQQLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQN-RHVKDKNIIELVHQVS 479 M +L +P +V+ G+C E +V E G L YL+ + + ++ ++E+ + V Sbjct: 55 QTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVC 114 Query: 480 MGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY 539 GM +LE F+HRDLAARN L+ K+SDFG+++ + D+ Y + K+PVKW Sbjct: 115 EGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQ--YVSSVGTKFPVKWS 172 Query: 540 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR 599 APE +Y+K+SSKSDVW+FG+LMWE FS G+ PY SEV + +G R+ P Sbjct: 173 APEVFHYFKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASD 232 Query: 600 EMYDLMNLCWTYDVENRPGFAAVELRLR 627 +Y +M CW E RP F + + Sbjct: 233 TIYQIMYSCWHELPEKRPTFQQLLSSIE 260 Score = 32.7 bits (73), Expect = 0.50, Method: Composition-based stats. Identities = 39/266 (14%), Positives = 79/266 (29%), Gaps = 55/266 (20%) Query: 130 EYVKQTWNLQGQALEQAIISQKP--QLEKLIATTAHEKMPWFHGKISREESEQIVLIGSK 187 K +++ + +++ +S+ Q + + +H K+ F+G S+E Sbjct: 27 GKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYP--------- 77 Query: 188 TNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYK 247 +++ +NG L G + + EG F Q + + Sbjct: 78 ---IYIVTEYISNGCLLNYLRSHG--KGLEPSQLLEMCYDVCEGMAFLESHQFI--HRDL 130 Query: 248 ADGLLRVLTVPCQKIGTQGNVN----------FGGRPQLPGSHPA------------TWS 285 A V C K+ G G + + S P W+ Sbjct: 131 AARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWA 190 Query: 286 AGGIISRIKSYS-FPKPGHR------KSSPAQGNRQESTVSFNPYEPELAPWAADKGPQR 338 G ++ + S P + K S + S Y+ + W Sbjct: 191 FGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQIMYSCW-------- 242 Query: 339 EALPMDTEVYESPYADPEEIRPKEVY 364 LP ++ + E +R K+ + Sbjct: 243 HELPEKRPTFQQLLSSIEPLREKDKH 268 >3KRL-A nrPDB Length = 335 Score = 276 bits (707), Expect = 2e-74, Method: Composition-based stats. Identities = 99/300 (33%), Positives = 154/300 (51%), Gaps = 26/300 (8%) Query: 352 YADPEEIR-PKEVYLDRKLLTLEDKELGSGNFGTVKKGY---YQMKKVVKTVAVKILKNE 407 + DP ++ ++ R L K LG+G FG V + + V VAVK+LK+ Sbjct: 29 FIDPTQLPYNEKWEFPRNNLQF-GKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKST 87 Query: 408 ANDPALKDELLAEANVMQQL-DNPYIVRMIGICEAESWMLV-MEMAELGPLNKYLQQNRH 465 A K+ L++E +M L + IV ++G C +LV E G L +L++ R Sbjct: 88 A-HADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRP 146 Query: 466 ----------------VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAK 509 + ++++ QV+ GM +L N +HRD+AARNVLL H AK Sbjct: 147 PGLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAK 206 Query: 510 ISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYG 569 I DFGL++ + D NY + + + PVKW APE I ++ +SDVWS+G+L+WE FS G Sbjct: 207 IGDFGLARDIMNDSNYI-VKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLG 265 Query: 570 QKPYRG-MKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 PY G + S+ +++ G +M PA P+ +Y +M CW + +RP F + L+ Sbjct: 266 LNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQE 325 >4R7H-A nrPDB Length = 343 Score = 275 bits (703), Expect = 5e-74, Method: Composition-based stats. Identities = 99/307 (32%), Positives = 155/307 (50%), Gaps = 33/307 (10%) Query: 352 YADPEEIR-PKEVYLDRKLLTLEDKELGSGNFGTVKKGY---YQMKKVVKTVAVKILKNE 407 + DP ++ ++ R L K LG+G FG V + + V VAVK+LK+ Sbjct: 33 FIDPTQLPYNEKWEFPRNNLQF-GKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKST 91 Query: 408 ANDPALKDELLAEANVMQQL-DNPYIVRMIGICEAESWMLV-MEMAELGPLNKYLQQN-- 463 A K+ L++E +M L + IV ++G C +LV E G L +L++ Sbjct: 92 A-HADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAE 150 Query: 464 ---------------------RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLL 502 R ++ ++++ QV+ GM +L N +HRD+AARNVLL Sbjct: 151 AMLGPSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLL 210 Query: 503 VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLM 562 H AKI DFGL++ + D NY + + + PVKW APE I ++ +SDVWS+G+L+ Sbjct: 211 TNGHVAKIGDFGLARDIMNDSNYI-VKGNARLPVKWMAPESIFDSVYTVQSDVWSYGILL 269 Query: 563 WEAFSYGQKPYRG-MKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAA 621 WE FS G PY G + S+ +++ G +M PA P+ +Y +M CW + +RP F Sbjct: 270 WEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQ 329 Query: 622 VELRLRN 628 + L+ Sbjct: 330 ITSFLQE 336 >3G0E-A nrPDB Length = 336 Score = 274 bits (702), Expect = 6e-74, Method: Composition-based stats. Identities = 101/301 (33%), Positives = 150/301 (49%), Gaps = 28/301 (9%) Query: 352 YADPEEIR-PKEVYLDRKLLTLEDKELGSGNFGTVKKGY---YQMKKVVKTVAVKILKNE 407 Y DP ++ + R L+ K LG+G FG V + TVAVK+LK Sbjct: 29 YIDPTQLPYDHKWEFPRNRLSF-GKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPS 87 Query: 408 ANDPALKDELLAEANVMQQL-DNPYIVRMIGICEAESWMLV-MEMAELGPLNKYLQQNRH 465 A ++ L++E V+ L ++ IV ++G C LV E G L +L++ R Sbjct: 88 A-HLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRD 146 Query: 466 ------------------VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHY 507 + ++++ +QV+ GM +L N +HRDLAARN+LL Sbjct: 147 SFICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRI 206 Query: 508 AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFS 567 KI DFGL++ ++ D N Y + + + PVKW APE I ++ +SDVWS+G+ +WE FS Sbjct: 207 TKICDFGLARDIKNDSN-YVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFS 265 Query: 568 YGQKPYRGMK-GSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 626 G PY GM S+ M+++G RM P P EMYD+M CW D RP F + + Sbjct: 266 LGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLI 325 Query: 627 R 627 Sbjct: 326 E 326 >3I81-A nrPDB Length = 315 Score = 274 bits (702), Expect = 6e-74, Method: Composition-based stats. Identities = 89/283 (31%), Positives = 159/283 (56%), Gaps = 17/283 (6%) Query: 360 PKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQM---KKVVKTVAVKILKNEANDPALKDE 416 P E + R+ +T+ +ELG G+FG V +G + + VA+K + NEA + E Sbjct: 10 PDEWEVAREKITMS-RELGQGSFGMVYEGVAKGVVKDEPETRVAIKTV-NEAASMRERIE 67 Query: 417 LLAEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKD------- 468 L EA+VM++ + ++VR++G+ + + +++ME+ G L YL+ R + Sbjct: 68 FLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAP 127 Query: 469 ---KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENY 525 +I++ +++ GM YL + FVHRDLAARN ++ KI DFG+++ + + +Y Sbjct: 128 PSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY-ETDY 186 Query: 526 YKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAML 585 Y+ G PV+W +PE + F++ SDVWSFGV++WE + ++PY+G+ +V + Sbjct: 187 YRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV 246 Query: 586 EKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 +G + P CP +++LM +CW Y+ + RP F + ++ Sbjct: 247 MEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKE 289 >6DBN-A nrPDB Length = 316 Score = 273 bits (699), Expect = 1e-73, Method: Composition-based stats. Identities = 104/317 (32%), Positives = 154/317 (48%), Gaps = 27/317 (8%) Query: 333 DKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYY-- 390 + E D + P + + ++ +L R ++LG G+FG V+ Y Sbjct: 5 RDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRI------RDLGEGHFGKVELCRYDP 58 Query: 391 QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAES---WMLV 447 + + VAVK LK E+ + D L E +++ L + IV+ GIC + L+ Sbjct: 59 EGDNTGEQVAVKSLKPESGGNHIAD-LKKEIEILRNLYHENIVKYKGICTEDGGNGIKLI 117 Query: 448 MEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQH 506 ME G L +YL +N++ + K ++ Q+ GM YL +VHRDLAARNVL+ ++H Sbjct: 118 MEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEH 177 Query: 507 YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAF 566 KI DFGL+KA+ D+ YY + PV WYAPEC+ KF SDVWSFGV + E Sbjct: 178 QVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELL 237 Query: 567 SYGQK-------------PYRG-MKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYD 612 +Y P G M + + L++G+R+ CP CP E+Y LM CW + Sbjct: 238 TYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQ 297 Query: 613 VENRPGFAAVELRLRNY 629 NR F + Sbjct: 298 PSNRTSFQNLIEGFEAL 314 >6FER-A nrPDB Length = 309 Score = 273 bits (697), Expect = 3e-73, Method: Composition-based stats. Identities = 101/296 (34%), Positives = 154/296 (52%), Gaps = 36/296 (12%) Query: 364 YLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVK--------------TVAVKILKNEAN 409 RKLLT ++K LG G FG V + + K VAVK+L+ +AN Sbjct: 5 EFPRKLLTFKEK-LGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADAN 63 Query: 410 DPALKDELLAEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQN----- 463 A +++ L E +M +L +P I+ ++ +C + ++ E E G LN++L ++ Sbjct: 64 KNA-RNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNS 122 Query: 464 -----RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKA 518 R V N+ + Q++ GMKYL NFVHRDLA RN L+ + KI+DFG+S+ Sbjct: 123 SSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRN 182 Query: 519 LRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQ-KPYRGMK 577 L + +YY+ Q P++W + E I KF++ SDVW+FGV +WE F++ Q +PY + Sbjct: 183 LYSG-DYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLS 241 Query: 578 GSEVTAMLEKGER-------MGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 626 +V + R + PA CP +Y LM CW D +NRP F + L L Sbjct: 242 DEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLL 297 >4XUF-A nrPDB Length = 297 Score = 272 bits (696), Expect = 3e-73, Method: Composition-based stats. Identities = 98/294 (33%), Positives = 149/294 (50%), Gaps = 32/294 (10%) Query: 362 EVYLDRKLLTLEDKELGSGNFGTVKKGY-YQMKKVV--KTVAVKILKNEANDPALKDELL 418 + R+ L K LGSG FG V Y + K VAVK+LK +A D + ++ L+ Sbjct: 3 KWEFPRENLEF-GKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKA-DSSEREALM 60 Query: 419 AEANVMQQL-DNPYIVRMIGICE-AESWMLVMEMAELGPLNKYLQQNRH----------- 465 +E +M QL + IV ++G C + L+ E G L YL+ R Sbjct: 61 SELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYEN 120 Query: 466 ------------VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDF 513 + ++++ +QV+ GM++LE + VHRDLAARNVL+ KI DF Sbjct: 121 QKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDF 180 Query: 514 GLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPY 573 GL++ + +D N Y + + + PVKW APE + ++ KSDVWS+G+L+WE FS G PY Sbjct: 181 GLARDIMSDSN-YVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPY 239 Query: 574 RGMK-GSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 626 G+ + +++ G +M P E+Y +M CW +D RP F + L Sbjct: 240 PGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 293 >6BSD-A nrPDB Length = 876 Score = 272 bits (696), Expect = 3e-73, Method: Composition-based stats. Identities = 109/425 (25%), Positives = 174/425 (40%), Gaps = 82/425 (19%) Query: 244 YSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGH 303 Y + PC G+ P+ PG ++ S P Sbjct: 484 YQEPRPRGNPPHSAPCVPNGSA-YSGDYMEPEKPG--------APLLPPPPQNSVPHYAE 534 Query: 304 RKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEV 363 QG +T + P L P A GP R P ++ Sbjct: 535 ADIVTLQGVTGGNTYAV----PALPPGAVGDGPPRVDFPRSRLRFK-------------- 576 Query: 364 YLDRKLLTLEDKELGSGNFGTVKKGYYQM--------------KKVVKTVAVKILKNEAN 409 ++LG G FG V K VAVKIL+ +A Sbjct: 577 -----------EKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDAT 625 Query: 410 DPALKDELLAEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNR---- 464 A +++ L E +M +L +P I+R++G+C + + ++ + E G LN++L ++ Sbjct: 626 KNA-RNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDK 684 Query: 465 ---------------HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAK 509 + ++ + Q++ GM+YL NFVHRDLA RN L+ K Sbjct: 685 AAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIK 744 Query: 510 ISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYG 569 I+DFG+S+ L A +YY+ Q P++W A ECI KF++ SDVW+FGV +WE Sbjct: 745 IADFGMSRNLYAG-DYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLC 803 Query: 570 Q-KPYRGMKGSEVTAMLEKGER-------MGCPAGCPREMYDLMNLCWTYDVENRPGFAA 621 + +P+ + +V + R + P CP+ +Y+LM CW+ + E RP F+ Sbjct: 804 RAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQ 863 Query: 622 VELRL 626 + L Sbjct: 864 LHRFL 868 >5X02-A nrPDB Length = 347 Score = 272 bits (695), Expect = 4e-73, Method: Composition-based stats. Identities = 98/294 (33%), Positives = 149/294 (50%), Gaps = 32/294 (10%) Query: 362 EVYLDRKLLTLEDKELGSGNFGTVKKGY-YQMKKVV--KTVAVKILKNEANDPALKDELL 418 + R+ L K LGSG FG V Y + K VAVK+LK +A D + ++ L+ Sbjct: 42 KWEFPRENLEF-GKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKA-DSSEREALM 99 Query: 419 AEANVMQQL-DNPYIVRMIGICE-AESWMLVMEMAELGPLNKYLQQNRH----------- 465 +E +M QL + IV ++G C + L+ E G L YL+ R Sbjct: 100 SELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYEN 159 Query: 466 ------------VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDF 513 + ++++ +QV+ GM++LE + VHRDLAARNVL+ KI DF Sbjct: 160 QKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDF 219 Query: 514 GLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPY 573 GL++ + +D N Y + + + PVKW APE + ++ KSDVWS+G+L+WE FS G PY Sbjct: 220 GLARDIMSDSN-YVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPY 278 Query: 574 RGMK-GSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 626 G+ + +++ G +M P E+Y +M CW +D RP F + L Sbjct: 279 PGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 332 >6FEX-A nrPDB Length = 321 Score = 271 bits (694), Expect = 5e-73, Method: Composition-based stats. Identities = 94/303 (31%), Positives = 150/303 (49%), Gaps = 39/303 (12%) Query: 360 PKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQM--------------KKVVKTVAVKILK 405 P V R L ++K LG G FG V K VAVKIL+ Sbjct: 8 PPRVDFPRSRLRFKEK-LGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILR 66 Query: 406 NEANDPALKDELLAEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNR 464 +A A +++ L E +M +L +P I+R++G+C + + ++ + E G LN++L ++ Sbjct: 67 PDATKNA-RNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQ 125 Query: 465 -------------HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKIS 511 + ++ + Q++ GM+YL NFVHRDLA RN L+ KI+ Sbjct: 126 LEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIA 185 Query: 512 DFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQ- 570 DFG+S+ L A +YY+ Q P++W A ECI KF++ SDVW+FGV +WE + Sbjct: 186 DFGMSRNLYAG-DYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRA 244 Query: 571 KPYRGMKGSEVTAMLEKGER-------MGCPAGCPREMYDLMNLCWTYDVENRPGFAAVE 623 +P+ + +V + R + P CP+ +Y+LM CW+ + E RP F+ + Sbjct: 245 QPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLH 304 Query: 624 LRL 626 L Sbjct: 305 RFL 307 >5WNO-A nrPDB Length = 330 Score = 271 bits (693), Expect = 7e-73, Method: Composition-based stats. Identities = 94/267 (35%), Positives = 154/267 (57%), Gaps = 9/267 (3%) Query: 368 KLLTLEDKELGSGNFGTVKKGYY---QMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424 +L T DK+LG+G FGTV G Y + K V VA+K+ + D + DE+L EA M Sbjct: 21 ELQTKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQ---TDQSQTDEMLEEATNM 77 Query: 425 QQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGM 482 +L + ++++IG C + +V LG L +L+ ++ ++ + + +Q++ GM Sbjct: 78 FRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGM 137 Query: 483 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 542 +YLE+ VHRDLA RNVL+ ++ +I+DFGLSK L+ D + ++ GK +KW A E Sbjct: 138 QYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKS-GKVAIKWLAIE 196 Query: 543 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 602 + + ++ SDVW+FGV WE ++GQ PY+GM + L+ G R+ P C +++Y Sbjct: 197 IFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLY 256 Query: 603 DLMNLCWTYDVENRPGFAAVELRLRNY 629 + CW D ++RPGF + R + + Sbjct: 257 QELLRCWMADPKSRPGFEILYERFKEF 283 >5GRN-A nrPDB Length = 356 Score = 271 bits (692), Expect = 8e-73, Method: Composition-based stats. Identities = 106/329 (32%), Positives = 152/329 (46%), Gaps = 36/329 (10%) Query: 334 KGPQREALPMDTEVYESPYADPEEIR-PKEVYLDRKLLTLEDKELGSGNFGTVKKGY--- 389 + R + + +E Y DP ++ R L L + LGSG FG V +G Sbjct: 11 EIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVL-GRVLGSGAFGKVVEGTAYG 69 Query: 390 YQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLD-NPYIVRMIGICEAE-SWMLV 447 + V VAVK+LK A K L++E +M L + IV ++G C ++ Sbjct: 70 LSRSQPVMKVAVKMLKPTARSSE-KQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYII 128 Query: 448 MEMAELGPLNKYLQQNRH--------------------------VKDKNIIELVHQVSMG 481 E G L YL +NR + +++ +QV+ G Sbjct: 129 TEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARG 188 Query: 482 MKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 541 M++L N VHRDLAARNVLL KI DFGL++ + D N Y ++ PVKW AP Sbjct: 189 MEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSN-YVSKGSTFLPVKWMAP 247 Query: 542 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMK-GSEVTAMLEKGERMGCPAGCPRE 600 E I +++ SDVWS+G+L+WE FS G PY GM S ++ G RM P E Sbjct: 248 ESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSE 307 Query: 601 MYDLMNLCWTYDVENRPGFAAVELRLRNY 629 +Y++M CW + E RP F + + N Sbjct: 308 VYEIMVKCWNSEPEKRPSFYHLSEIVENL 336 >5D9K-A nrPDB Length = 330 Score = 270 bits (691), Expect = 1e-72, Method: Composition-based stats. Identities = 71/300 (23%), Positives = 134/300 (44%), Gaps = 10/300 (3%) Query: 340 ALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYY-QMKKVVKT 398 P EV A ++ D L K LG G+FG V + Sbjct: 2 PNPQTEEVSIKEIAITHHVKEGHEKADPSQFELL-KVLGQGSFGKVFLVKKISGSDARQL 60 Query: 399 VAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAES-WMLVMEMAELGPLN 457 A+K+LK + E +++ ++++P+IV++ + E L+++ G L Sbjct: 61 YAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLF 120 Query: 458 KYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSK 517 L + ++++ + ++++ + +L ++RDL N+LL + + K++DFGLSK Sbjct: 121 TRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSK 180 Query: 518 ALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMK 577 ++ K V++ APE +N + +D WSFGVLM+E + G P++G Sbjct: 181 E---SIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLT-GTLPFQGKD 236 Query: 578 GSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGF--AAVELRLRNYYYDVVN 635 E M+ K + +G P E L+ + + + NR G VE R+ ++ ++ Sbjct: 237 RKETMTMILKAK-LGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTID 295 >2W1I-A nrPDB Length = 326 Score = 270 bits (690), Expect = 1e-72, Method: Composition-based stats. Identities = 96/291 (32%), Positives = 154/291 (52%), Gaps = 29/291 (9%) Query: 364 YLDRKLLTLEDK------ELGSGNFGTVKKGYYQ--MKKVVKTVAVKILKNEANDPALKD 415 + DR E++ +LG GNFG+V+ Y + VAVK L++ + Sbjct: 30 FEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEE--HLR 87 Query: 416 ELLAEANVMQQLDNPYIVRMIGICEA---ESWMLVMEMAELGPLNKYLQQNR-HVKDKNI 471 + E +++ L + IV+ G+C + + L+ME G L YLQ+++ + + Sbjct: 88 DFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKL 147 Query: 472 IELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTH 531 ++ Q+ GM+YL ++HRDLA RN+L+ ++ KI DFGL+K L D+ YYK + Sbjct: 148 LQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEP 207 Query: 532 GKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQ----KP--YRGMKGSE----- 580 G+ P+ WYAPE + KFS SDVWSFGV+++E F+Y + P + M G++ Sbjct: 208 GESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM 267 Query: 581 ----VTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 + +L+ R+ P GCP E+Y +M CW +V RP F + LR+ Sbjct: 268 IVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVD 318 >3IO7-A nrPDB Length = 313 Score = 269 bits (688), Expect = 3e-72, Method: Composition-based stats. Identities = 93/274 (33%), Positives = 149/274 (54%), Gaps = 23/274 (8%) Query: 375 KELGSGNFGTVKKGYYQ--MKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 ++LG GNFG+V+ Y + VAVK L++ + + E +++ L + I Sbjct: 34 QQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEE--HLRDFEREIEILKSLQHDNI 91 Query: 433 VRMIGICEA---ESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEES 488 V+ G+C + + L+ME G L YLQ+++ + +++ Q+ GM+YL Sbjct: 92 VKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTK 151 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 ++HRDLA RN+L+ ++ KI DFGL+K L D+ YYK + G+ P+ WYAPE + K Sbjct: 152 RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESK 211 Query: 549 FSSKSDVWSFGVLMWEAFSYGQ----KP--YRGMKGSE---------VTAMLEKGERMGC 593 FS SDVWSFGV+++E F+Y + P + M G++ + +L+ R+ Sbjct: 212 FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPR 271 Query: 594 PAGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 P GCP E+Y +M CW +V RP F + LR+ Sbjct: 272 PDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVD 305 >4UY9-A nrPDB Length = 323 Score = 267 bits (683), Expect = 1e-71, Method: Composition-based stats. Identities = 83/281 (29%), Positives = 137/281 (48%), Gaps = 27/281 (9%) Query: 363 VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEAND--PALKDELLAE 420 + +D LTLE + +G G FG V + ++ + VAVK +++ ++ + + E Sbjct: 4 LEIDFAELTLE-EIIGIGGFGKVYRAFW----IGDEVAVKAARHDPDEDISQTIENVRQE 58 Query: 421 ANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVS 479 A + L +P I+ + G+C + + LVME A GPLN+ L + + ++ Q++ Sbjct: 59 AKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL-SGKRIPPDILVNWAVQIA 117 Query: 480 MGMKYLEESNF---VHRDLAARNVLLV--------TQHYAKISDFGLSKALRADENYYKA 528 GM YL + +HRDL + N+L++ + KI+DFGL++ + Sbjct: 118 RGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREW-----HRTT 172 Query: 529 QTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG 588 + W APE I FS SDVWS+GVL+WE + G+ P+RG+ G V + Sbjct: 173 KMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVAMN 231 Query: 589 E-RMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 + + P+ CP LM CW D +RP F + +L Sbjct: 232 KLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTT 272 >3DTC-A nrPDB Length = 271 Score = 267 bits (682), Expect = 1e-71, Method: Composition-based stats. Identities = 83/281 (29%), Positives = 137/281 (48%), Gaps = 27/281 (9%) Query: 363 VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEAND--PALKDELLAE 420 + +D LTLE + +G G FG V + ++ + VAVK +++ ++ + + E Sbjct: 2 LEIDFAELTLE-EIIGIGGFGKVYRAFW----IGDEVAVKAARHDPDEDISQTIENVRQE 56 Query: 421 ANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVS 479 A + L +P I+ + G+C + + LVME A GPLN+ L + + ++ Q++ Sbjct: 57 AKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL-SGKRIPPDILVNWAVQIA 115 Query: 480 MGMKYLEESNF---VHRDLAARNVLLV--------TQHYAKISDFGLSKALRADENYYKA 528 GM YL + +HRDL + N+L++ + KI+DFGL++ + Sbjct: 116 RGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREW-----HRTT 170 Query: 529 QTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG 588 + W APE I FS SDVWS+GVL+WE + G+ P+RG+ G V + Sbjct: 171 KMSAAGAYAWMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVAMN 229 Query: 589 E-RMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 + + P+ CP LM CW D +RP F + +L Sbjct: 230 KLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTT 270 >3HZT-A nrPDB Length = 467 Score = 266 bits (680), Expect = 2e-71, Method: Composition-based stats. Identities = 73/255 (28%), Positives = 114/255 (44%), Gaps = 16/255 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEA-NDPALKDELLAEANVMQQLDNPYIV 433 K+LGSG +G V ++ + A+KI+K + + LL E V++QLD+P I+ Sbjct: 10 KKLGSGAYGEVLLCKDKLTGAER--AIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPNIM 67 Query: 434 RMIGICEAE-SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 ++ E + ++ LVME+ G L + + + + ++ QV G YL + N VH Sbjct: 68 KLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKHNIVH 127 Query: 493 RDLAARNVLLVTQHY---AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 RDL N+LL ++ KI DFGLS + APE + K+ Sbjct: 128 RDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKM----KERLGTAYYIAPEVL-RKKY 182 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGC---PREMYDLMN 606 K DVWS GV+++ G P+ G E+ +EKG+ P E L+ Sbjct: 183 DEKCDVWSCGVILYILLC-GYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLVK 241 Query: 607 LCWTYDVENRPGFAA 621 L TY+ R Sbjct: 242 LMLTYEPSKRISAEE 256 >4MVF-A nrPDB Length = 506 Score = 266 bits (679), Expect = 3e-71, Method: Composition-based stats. Identities = 73/264 (27%), Positives = 120/264 (45%), Gaps = 20/264 (7%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPY 431 + D++LG G +G V KG K + A+K K + + E +M++LD+P Sbjct: 60 IIDEKLGQGTYGCVYKGID--KVTNQLYAIKEEKKDRLKNI--NRFFQEIEIMKKLDHPN 115 Query: 432 IVRMIGICEAESW-MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 IV++ E +++ L+ME+ L + +N +KN ++ Q+ + YL N Sbjct: 116 IVKLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLNI 175 Query: 491 VHRDLAARNVLLVTQHY---AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY 547 VHRDL N L +++ KI DFGLSK L E T + AP+ ++ Sbjct: 176 VHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGE----FTTTKAGTPYYVAPQVLDG- 230 Query: 548 KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGC---PREMYDL 604 K+ K D+WS GV+M+ G P+ G +EV ++KGE + +L Sbjct: 231 KYDKKCDIWSSGVIMYTLLC-GYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISSDAKNL 289 Query: 605 MNLCWTYDVENRPGFAAVELRLRN 628 + TY+ R +E L + Sbjct: 290 ITKLLTYNPNER---CTIEEALNH 310 >2QNJ-A nrPDB Length = 328 Score = 265 bits (677), Expect = 5e-71, Method: Composition-based stats. Identities = 69/250 (27%), Positives = 112/250 (44%), Gaps = 10/250 (4%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K +G GNF VK + + + VA+KI+ +P +L E +M+ L++P IV+ Sbjct: 18 KTIGKGNFAKVKLARHIL--TGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVK 75 Query: 435 MIGICEAE-SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + + E E + L+ME A G + YL + +K+K Q+ ++Y + VHR Sbjct: 76 LFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHR 135 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS-SK 552 DL A N+LL KI+DFG S K T P + APE K+ + Sbjct: 136 DLKAENLLLDADMNIKIADFGFSNEFTVGG---KLDTFCGSPP-YAAPELFQGKKYDGPE 191 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYD 612 DVWS GV+++ S G P+ G E+ + +G+ P + +L+ + Sbjct: 192 VDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRGK-YRIPFYMSTDCENLLKRFLVLN 249 Query: 613 VENRPGFAAV 622 R + Sbjct: 250 PIKRGTLEQI 259 >3PLS-A nrPDB Length = 298 Score = 265 bits (677), Expect = 5e-71, Method: Composition-based stats. Identities = 93/272 (34%), Positives = 147/272 (54%), Gaps = 7/272 (2%) Query: 358 IRPKEVYLDR-KLLTLEDKELGSGNFGTVKKGYYQMKKVVK-TVAVKILKNEANDPALKD 415 K+V + +++T D+ +G G+FG V G Y + + A+K L + + Sbjct: 9 AEVKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLS-RITEMQQVE 67 Query: 416 ELLAEANVMQQLDNPYIVRMIGICEAESWM--LVMEMAELGPLNKYLQQ-NRHVKDKNII 472 L E +M+ L++P ++ +IGI + +++ G L ++++ R+ K++I Sbjct: 68 AFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLI 127 Query: 473 ELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQ-TH 531 QV+ GM+YL E FVHRDLAARN +L K++DFGL++ + E Y Q H Sbjct: 128 SFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRH 187 Query: 532 GKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERM 591 + PVKW A E + Y+F++KSDVWSFGVL+WE + G PYR + ++T L +G R+ Sbjct: 188 ARLPVKWTALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRL 247 Query: 592 GCPAGCPREMYDLMNLCWTYDVENRPGFAAVE 623 P CP +Y +M CW D RP F + Sbjct: 248 PQPEYCPDSLYQVMQQCWEADPAVRPTFRVLV 279 >3ZZW-A nrPDB Length = 289 Score = 265 bits (677), Expect = 5e-71, Method: Composition-based stats. Identities = 94/275 (34%), Positives = 146/275 (53%), Gaps = 22/275 (8%) Query: 375 KELGSGNFGTVKKGYY---QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPY 431 +ELG FG V KG+ + + VA+K LK++A P L++E EA + +L +P Sbjct: 15 EELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGP-LREEFRHEAMLRARLQHPN 73 Query: 432 IVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRH----------------VKDKNIIEL 474 +V ++G+ + + ++ G L+++L ++ + + L Sbjct: 74 VVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHL 133 Query: 475 VHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKW 534 V Q++ GM+YL + VH+DLA RNVL+ + KISD GL + + A +YYK + Sbjct: 134 VAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYA-ADYYKLLGNSLL 192 Query: 535 PVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP 594 P++W APE I Y KFS SD+WS+GV++WE FSYG +PY G +V M+ + + CP Sbjct: 193 PIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCP 252 Query: 595 AGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNY 629 CP +Y LM CW RP F + RLR + Sbjct: 253 DDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAW 287 >3PPZ-A nrPDB Length = 309 Score = 264 bits (676), Expect = 6e-71, Method: Composition-based stats. Identities = 78/281 (27%), Positives = 138/281 (49%), Gaps = 16/281 (5%) Query: 361 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 420 ++ + L +++K +G+G+FGTV + + VAVKIL + +E L E Sbjct: 30 DDMDIPWCDLNIKEK-IGAGSFGTVHRAEWHGSD----VAVKILMEQDFHAERVNEFLRE 84 Query: 421 ANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQ---NRHVKDKNIIELVH 476 +M++L +P IV +G + +V E G L + L + + ++ + + + Sbjct: 85 VAIMKRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAY 144 Query: 477 QVSMGMKYLEESN--FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKW 534 V+ GM YL N VHRDL + N+L+ ++ K+ DFGLS+ + + + Sbjct: 145 DVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRL---KASTFLSSKSAAG 201 Query: 535 PVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLE-KGERMGC 593 +W APE + + KSDV+SFGV++WE + Q+P+ + ++V A + K +R+ Sbjct: 202 TPEWMAPEVLRDEPSNEKSDVYSFGVILWELATL-QQPWGNLNPAQVVAAVGFKCKRLEI 260 Query: 594 PAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVV 634 P ++ ++ CWT + RP FA + LR V Sbjct: 261 PRNLNPQVAAIIEGCWTNEPWKRPSFATIMDLLRPLIKSAV 301 >3AOX-A nrPDB Length = 344 Score = 264 bits (675), Expect = 7e-71, Method: Composition-based stats. Identities = 95/284 (33%), Positives = 144/284 (50%), Gaps = 17/284 (5%) Query: 363 VYLDRKLLTLEDKELGSGNFGTVKKGYYQM---KKVVKTVAVKILKNEANDPALKDELLA 419 + RK +TL + LG G FG V +G VAVK L E + + L Sbjct: 42 KEVPRKNITLI-RGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTL-PEVCSEQDELDFLM 99 Query: 420 EANVMQQLDNPYIVRMIGI-CEAESWMLVMEMAELGPLNKYLQQNRHVKDK-------NI 471 EA ++ + ++ IVR IG+ ++ +++E+ G L +L++ R + ++ Sbjct: 100 EALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDL 159 Query: 472 IELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQH---YAKISDFGLSKALRADENYYKA 528 + + ++ G +YLEE++F+HRD+AARN LL AKI DFG+++ + +YY+ Sbjct: 160 LHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYR-ASYYRK 218 Query: 529 QTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG 588 PVKW PE F+SK+D WSFGVL+WE FS G PY EV + G Sbjct: 219 GGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSG 278 Query: 589 ERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYD 632 RM P CP +Y +M CW + E+RP FA + R+ D Sbjct: 279 GRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQD 322 >3DXN-A nrPDB Length = 287 Score = 264 bits (674), Expect = 1e-70, Method: Composition-based stats. Identities = 73/255 (28%), Positives = 114/255 (44%), Gaps = 16/255 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEA-NDPALKDELLAEANVMQQLDNPYIV 433 K+LGSG +G V ++ + A+KI+K + + LL E V++QLD+P I+ Sbjct: 27 KKLGSGAYGEVLLCKDKLTGAER--AIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPNIM 84 Query: 434 RMIGICEAE-SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 ++ E + ++ LVME+ G L + + + + ++ QV G YL + N VH Sbjct: 85 KLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKHNIVH 144 Query: 493 RDLAARNVLLVTQHY---AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 RDL N+LL ++ KI DFGLS + APE + K+ Sbjct: 145 RDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKM----KERLGTAYYIAPEVL-RKKY 199 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGC---PREMYDLMN 606 K DVWS GV+++ G P+ G E+ +EKG+ P E L+ Sbjct: 200 DEKCDVWSCGVILYILLC-GYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLVK 258 Query: 607 LCWTYDVENRPGFAA 621 L TY+ R Sbjct: 259 LMLTYEPSKRISAEE 273 >5KZ7-A nrPDB Length = 346 Score = 263 bits (673), Expect = 1e-70, Method: Composition-based stats. Identities = 71/250 (28%), Positives = 112/250 (44%), Gaps = 10/250 (4%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K +G GNF VK + + K VAVKI+ + + +L E +M+ L++P IV+ Sbjct: 39 KTIGKGNFAKVKLARHIL--TGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVK 96 Query: 435 MIGICEAE-SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + + E E + LVME A G + YL + +K+K Q+ ++Y + VHR Sbjct: 97 LFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHR 156 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS-SK 552 DL A N+LL KI+DFG S K T P + APE K+ + Sbjct: 157 DLKAENLLLDADMNIKIADFGFSNEFTFGN---KLDTFCGSPP-YAAPELFQGKKYDGPE 212 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYD 612 DVWS GV+++ S G P+ G E+ + +G+ P + +L+ + Sbjct: 213 VDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRGK-YRIPFYMSTDCENLLKKFLILN 270 Query: 613 VENRPGFAAV 622 R + Sbjct: 271 PSKRGTLEQI 280 >3Q5I-A nrPDB Length = 504 Score = 263 bits (673), Expect = 1e-70, Method: Composition-based stats. Identities = 72/282 (25%), Positives = 121/282 (42%), Gaps = 28/282 (9%) Query: 358 IRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDP------ 411 +R KE + + ++LGSG +G V + K A+K++K D Sbjct: 27 VRKKEGKIGESYFKV--RKLGSGAYGEVLLC--KEKNGHSEKAIKVIKKSQFDKGRYSDD 82 Query: 412 -----ALKDELLAEANVMQQLDNPYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRH 465 +E+ E ++++ LD+P I+++ + E + + LV E E G L + + Sbjct: 83 NKNIEKFHEEIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHK 142 Query: 466 VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQH---YAKISDFGLSKALRAD 522 + + ++ Q+ G+ YL + N VHRD+ N+LL ++ KI DFGLS D Sbjct: 143 FDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKD 202 Query: 523 ENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVT 582 + APE + K++ K DVWS GV+M+ G P+ G ++ Sbjct: 203 ----YKLRDRLGTAYYIAPEVLK-KKYNEKCDVWSCGVIMYILLC-GYPPFGGQNDQDII 256 Query: 583 AMLEKGER---MGCPAGCPREMYDLMNLCWTYDVENRPGFAA 621 +EKG+ E +L+ L TYD R Sbjct: 257 KKVEKGKYYFDFNDWKNISDEAKELIKLMLTYDYNKRCTAEE 298 >2Z7Q-A nrPDB Length = 321 Score = 263 bits (672), Expect = 2e-70, Method: Composition-based stats. Identities = 64/265 (24%), Positives = 124/265 (46%), Gaps = 9/265 (3%) Query: 375 KELGSGNFGTVKKGYYQMK-KVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 K LG G+FG V + A+K+LK + E +++ +++P++V Sbjct: 34 KVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVV 93 Query: 434 RMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 ++ + E L+++ G L L + ++++ + ++++G+ +L ++ Sbjct: 94 KLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIY 153 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSK 552 RDL N+LL + + K++DFGLSK ++ K V++ APE +N S Sbjct: 154 RDLKPENILLDEEGHIKLTDFGLSKEAI---DHEKKAYSFCGTVEYMAPEVVNRQGHSHS 210 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYD 612 +D WS+GVLM+E + G P++G E ++ K + +G P E L+ + + Sbjct: 211 ADWWSYGVLMFEMLT-GSLPFQGKDRKETMTLILKAK-LGMPQFLSTEAQSLLRALFKRN 268 Query: 613 VENRPGF--AAVELRLRNYYYDVVN 635 NR G E R+ +Y ++ Sbjct: 269 PANRLGSGPDGAEEIKRHVFYSTID 293 >5ES1-A nrPDB Length = 328 Score = 263 bits (671), Expect = 2e-70, Method: Composition-based stats. Identities = 68/250 (27%), Positives = 113/250 (45%), Gaps = 10/250 (4%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 + +G GNF VK + + + VA+KI+ +P+ +L E +M+ L++P IV+ Sbjct: 21 RTIGKGNFAKVKLARHIL--TGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVK 78 Query: 435 MIGICEAE-SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + + E E + LVME A G + YL + +K+K Q+ + Y + N VHR Sbjct: 79 LFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHR 138 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS-SK 552 DL A N+LL + KI+DFG S K T P + APE K+ + Sbjct: 139 DLKAENLLLDAEANIKIADFGFSNEFTLGS---KLDTFCGSPP-YAAPELFQGKKYDGPE 194 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYD 612 D+WS GV+++ S G P+ G E+ + +G+ P + ++ + Sbjct: 195 VDIWSLGVILYTLVS-GSLPFDGHNLKELRERVLRGK-YRVPFYMSTDCESILRRFLVLN 252 Query: 613 VENRPGFAAV 622 R + Sbjct: 253 PAKRCTLEQI 262 >3LIJ-A nrPDB Length = 494 Score = 261 bits (667), Expect = 6e-70, Method: Composition-based stats. Identities = 71/258 (27%), Positives = 116/258 (44%), Gaps = 15/258 (5%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K+LGSG +G V ++ V + A+KI++ + + +LL E V++ LD+P I++ Sbjct: 43 KKLGSGAYGEVLLCRDKVTHVER--AIKIIRKTSVSTSSNSKLLEEVAVLKLLDHPNIMK 100 Query: 435 MIGICEAE-SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + E + ++ LVME + G L + + + ++ QV G+ YL + N VHR Sbjct: 101 LYDFFEDKRNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHKHNIVHR 160 Query: 494 DLAARNVLLVTQHY---AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 DL N+LL ++ KI DFGLS K + APE + K+ Sbjct: 161 DLKPENLLLESKEKDALIKIVDFGLSAVFEN----QKKMKERLGTAYYIAPEVL-RKKYD 215 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE-RMGCPA--GCPREMYDLMNL 607 K DVWS GV+++ + G P+ G E+ +EKG+ P DL+ Sbjct: 216 EKCDVWSIGVILFILLA-GYPPFGGQTDQEILRKVEKGKYTFDSPEWKNVSEGAKDLIKQ 274 Query: 608 CWTYDVENRPGFAAVELR 625 +D + R Sbjct: 275 MLQFDSQRRISAQQALEH 292 >3NCG-A nrPDB Length = 486 Score = 260 bits (665), Expect = 1e-69, Method: Composition-based stats. Identities = 63/256 (24%), Positives = 111/256 (43%), Gaps = 15/256 (5%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 LG G+FG V K ++ + AVK++ + +L E ++++LD+P I+++ Sbjct: 30 LGKGSFGEVLKCKDRI--TQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPNIMKLF 87 Query: 437 GICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDL 495 I E S + +V E+ G L + + + + + ++ QV G+ Y+ + N VHRDL Sbjct: 88 EILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHNIVHRDL 147 Query: 496 AARNVLLVT---QHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSK 552 N+LL + KI DFGLS + + + APE + + K Sbjct: 148 KPENILLESKEKDCDIKIIDFGLSTCFQQNTKM----KDRIGTAYYIAPEVLRGT-YDEK 202 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGER---MGCPAGCPREMYDLMNLCW 609 DVWS GV+++ S G P+ G ++ +E G+ + + DL+ Sbjct: 203 CDVWSAGVILYILLS-GTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLIRKML 261 Query: 610 TYDVENRPGFAAVELR 625 T+ R Sbjct: 262 TFHPSLRITATQCLEH 277 >5IG1-A nrPDB Length = 344 Score = 260 bits (665), Expect = 1e-69, Method: Composition-based stats. Identities = 58/277 (20%), Positives = 114/277 (41%), Gaps = 18/277 (6%) Query: 359 RPKEVYLDRKLLTLEDK--ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE 416 + + D + L+DK +G G F TV + K+ + AVK++ ++ + ++ Sbjct: 5 ETETSFFDLYDVDLKDKRSVIGKGAFSTVHRCVN--KRTGEVCAVKVIALKSLRSSEINK 62 Query: 417 LLAEANVMQQLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELV 475 + E + L + +IV M E + LV E G L + + +K+ + Sbjct: 63 IKREIGICSSLQHEHIVSMRRAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEKDASACM 122 Query: 476 HQVSMGMKYLEESNFVHRDLAARNVLLVTQH---YAKISDFGLSKALRADENYYKAQTHG 532 HQ+ +++ N +HRDL N+LL ++ KI+DFGL+ + Y+ Sbjct: 123 HQILSALQHCHSKNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYF----GF 178 Query: 533 KWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMG 592 + +PE I + + DVW+ GV+++ G P+ ++ A + K + Sbjct: 179 AGTPGYLSPEVIRRVPYDTAVDVWACGVILYILL-VGYPPFWEEDHQKLYAQI-KNCQYD 236 Query: 593 CPA----GCPREMYDLMNLCWTYDVENRPGFAAVELR 625 P+ +L+ + + RP + Sbjct: 237 FPSPEWDSVTTAAKELIKAMLEPNPKRRPTVQELLQH 273 >5JN2-A nrPDB Length = 525 Score = 260 bits (664), Expect = 1e-69, Method: Composition-based stats. Identities = 67/255 (26%), Positives = 112/255 (43%), Gaps = 16/255 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNPYIV 433 + LG G+FG V ++ + AVK++ K + K+ LL E +++QLD+P I+ Sbjct: 73 RVLGKGSFGEVILCKDKI--TGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIM 130 Query: 434 RMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 ++ E + + LV E+ G L + + + + ++ QV G+ Y+ ++ VH Sbjct: 131 KLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVH 190 Query: 493 RDLAARNVLL---VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 RDL N+LL +I DFGLS A K + APE ++ + Sbjct: 191 RDLKPENLLLESKSKDANIRIIDFGLSTHFEAS----KKMKDKIGTAYYIAPEVLHGT-Y 245 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE---RMGCPAGCPREMYDLMN 606 K DVWS GV+++ S G P+ G ++ +EKG+ + DL+ Sbjct: 246 DEKCDVWSTGVILYILLS-GCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIR 304 Query: 607 LCWTYDVENRPGFAA 621 TY R Sbjct: 305 KMLTYVPSMRISARD 319 >4UYA-A nrPDB Length = 340 Score = 259 bits (661), Expect = 4e-69, Method: Composition-based stats. Identities = 87/282 (30%), Positives = 132/282 (46%), Gaps = 29/282 (10%) Query: 360 PKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILK--NEANDPALKDEL 417 P V +R L + +G+G FG V + +Q + VAVK + E + A + + Sbjct: 20 PVHVAFERLELK---ELIGAGGFGQVYRATWQ----GQEVAVKAARQDPEQDAAAAAESV 72 Query: 418 LAEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVH 476 EA + L +P I+ + G+C + LV+E A G LN+ L R + ++ Sbjct: 73 RREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRAL-AGRRIPPHVLVNWAV 131 Query: 477 QVSMGMKYLEESN---FVHRDLAARNVLLVT--------QHYAKISDFGLSKALRADENY 525 Q++ GM YL E +HRDL + N+LL+ KI+DFGL++ + Sbjct: 132 QIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREW-----H 186 Query: 526 YKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAML 585 + W APE I FS SD+WS+GVL+WE + G+ PYRG+ G V + Sbjct: 187 RTTKMATAGAYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLT-GEVPYRGIDGLAVAYGV 245 Query: 586 EKGE-RMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 626 + + P+ CP LM CW D RP FA + +L Sbjct: 246 AVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQL 287 >3DFA-A nrPDB Length = 286 Score = 258 bits (660), Expect = 4e-69, Method: Composition-based stats. Identities = 63/256 (24%), Positives = 111/256 (43%), Gaps = 15/256 (5%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 LG G+FG V K ++ + AVK++ + +L E ++++LD+P I+++ Sbjct: 30 LGKGSFGEVLKCKDRI--TQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPNIMKLF 87 Query: 437 GICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDL 495 I E S + +V E+ G L + + + + + ++ QV G+ Y+ + N VHRDL Sbjct: 88 EILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHNIVHRDL 147 Query: 496 AARNVLLVT---QHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSK 552 N+LL + KI DFGLS + + + APE + + K Sbjct: 148 KPENILLESKEKDCDIKIIDFGLSTCFQQNTKM----KDRIGTAYYIAPEVLRGT-YDEK 202 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGER---MGCPAGCPREMYDLMNLCW 609 DVWS GV+++ S G P+ G ++ +E G+ + + DL+ Sbjct: 203 CDVWSAGVILYILLS-GTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLIRKML 261 Query: 610 TYDVENRPGFAAVELR 625 T+ R Sbjct: 262 TFHPSLRITATQCLEH 277 >6FDY-U nrPDB Length = 276 Score = 258 bits (660), Expect = 4e-69, Method: Composition-based stats. Identities = 63/261 (24%), Positives = 127/261 (48%), Gaps = 11/261 (4%) Query: 366 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 425 R + + LGSG + TV K Y K + VA+K + ++ + A + LL E +++ Sbjct: 8 PRLDGFILTERLGSGTYATVYKA-YAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILK 66 Query: 426 QLDNPYIVRMIGI-CEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKY 484 + +P+IV++ ++++ L+ME G L++++ R + +K + Q++ +++ Sbjct: 67 GIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQF 126 Query: 485 LEESNFVHRDLAARNVLLV--TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 542 L E N H DL +N+LL + + K++DFG ++ + + + + + APE Sbjct: 127 LHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVL----RGSPLYMAPE 182 Query: 543 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP--AGCPRE 600 + ++ ++ D+WS GV+++EA +GQ P+ SE+ + + P R+ Sbjct: 183 MVCQRQYDARVDLWSMGVILYEAL-FGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRD 241 Query: 601 MYDLMNLCWTYDVENRPGFAA 621 DL+ D R F Sbjct: 242 CRDLLQRLLERDPSRRISFQD 262 >4HVI-A nrPDB Length = 314 Score = 258 bits (660), Expect = 5e-69, Method: Composition-based stats. Identities = 98/272 (36%), Positives = 154/272 (56%), Gaps = 22/272 (8%) Query: 376 ELGSGNFGTVKKGYYQ--MKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 +LG GNFG+V+ Y VAVK L + + P + + E +++ L + +IV Sbjct: 17 QLGKGNFGSVELCRYDPLGDNTGALVAVKQL--QHSGPDQQRDFQREIQILKALHSDFIV 74 Query: 434 RMIGICEA---ESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESN 489 + G+ +S LVME G L +LQ++R + ++ Q+ GM+YL Sbjct: 75 KYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRR 134 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 VHRDLAARN+L+ ++ + KI+DFGL+K L D++YY + G+ P+ WYAPE ++ F Sbjct: 135 CVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIF 194 Query: 550 SSKSDVWSFGVLMWEAFSYG---QKP---YRGMKGSE--------VTAMLEKGERMGCPA 595 S +SDVWSFGV+++E F+Y P + M GSE + +LE+G+R+ P Sbjct: 195 SRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEGQRLPAPP 254 Query: 596 GCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 CP E+++LM LCW ++RP F+A+ +L Sbjct: 255 ACPAEVHELMKLCWAPSPQDRPSFSALGPQLD 286 >5VO2-A nrPDB Length = 300 Score = 258 bits (660), Expect = 5e-69, Method: Composition-based stats. Identities = 77/266 (28%), Positives = 122/266 (45%), Gaps = 20/266 (7%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPY 431 L+ + +GSG G V G + + VAVK +++ +++L +P Sbjct: 15 LDLQWVGSGAQGAVFLGRFH----GEEVAVKKVRDLKETD---------IKHLRKLKHPN 61 Query: 432 IVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 I+ G+C +A + ++ME G L + L+ R V +++ ++ GM YL Sbjct: 62 IITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKI 121 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 +HRDL + N+L+ KISDFG SK L + V W APE I S Sbjct: 122 IHRDLKSPNMLITYDDVVKISDFGTSKELSDKS----TKMSFAGTVAWMAPEVIRNEPVS 177 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE-RMGCPAGCPREMYDLMNLCW 609 K D+WSFGV++WE + G+ PY+ + S + + + P+ CP L+ CW Sbjct: 178 EKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCW 236 Query: 610 TYDVENRPGFAAVELRLRNYYYDVVN 635 NRP F + L L DV++ Sbjct: 237 NSKPRNRPSFRQILLHLDIASADVLS 262 >4GS6-A nrPDB Length = 315 Score = 257 bits (656), Expect = 1e-68, Method: Composition-based stats. Identities = 74/275 (26%), Positives = 122/275 (44%), Gaps = 26/275 (9%) Query: 364 YLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANV 423 +D K + +E + +G G FG V K ++ K VA+K +++E+ + + E Sbjct: 5 MIDYKEIEVE-EVVGRGAFGVVCKAKWRAKD----VAIKQIESESE----RKAFIVELRQ 55 Query: 424 MQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVK---DKNIIELVHQVSM 480 + ++++P IV++ G C LVME AE G L L + + + Q S Sbjct: 56 LSRVNHPNIVKLYGACL-NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQ 114 Query: 481 GMKYLEE---SNFVHRDLAARNVLLVTQHYA-KISDFGLSKALRADENYYKAQTHGKWPV 536 G+ YL +HRDL N+LLV KI DFG + ++ T+ K Sbjct: 115 GVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQ------THMTNNKGSA 168 Query: 537 KWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYR--GMKGSEVTAMLEKGERMGCP 594 W APE +S K DV+S+G+++WE + +KP+ G + + G R Sbjct: 169 AWMAPEVFEGSNYSEKCDVFSWGIILWEVITR-RKPFDEIGGPAFRIMWAVHNGTRPPLI 227 Query: 595 AGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNY 629 P+ + LM CW+ D RP + + + Sbjct: 228 KNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHL 262 >5YKS-A nrPDB Length = 377 Score = 257 bits (656), Expect = 1e-68, Method: Composition-based stats. Identities = 62/254 (24%), Positives = 111/254 (43%), Gaps = 12/254 (4%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 DK LG G+F VK + + VAVK++ D L E M+ + +P IV Sbjct: 40 DKTLGRGHFAVVKLARHVF--TGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIV 97 Query: 434 RMIGICEAES-WMLVMEMAELGPLNKYLQQN-RHVKDKNIIELVHQVSMGMKYLEESNFV 491 R+ + + ++ L++E+ + G + Y+ ++ + + + Q+ + Y + + V Sbjct: 98 RLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVV 157 Query: 492 HRDLAARN-VLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 HRDL N V Q K++DFG S + K T + + APE + ++ Sbjct: 158 HRDLKPENVVFFEKQGLVKLTDFGFSNKFQPG----KKLTTSCGSLAYSAPEILLGDEYD 213 Query: 551 -SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCW 609 D+WS GV+++ GQ P++ SE M+ + P+ +E DL+ Sbjct: 214 APAVDIWSLGVILF-MLVCGQPPFQEANDSETLTMIMDCK-YTVPSHVSKECKDLITRML 271 Query: 610 TYDVENRPGFAAVE 623 D + R +E Sbjct: 272 QRDPKRRASLEEIE 285 >3MA6-A nrPDB Length = 298 Score = 256 bits (654), Expect = 2e-68, Method: Composition-based stats. Identities = 67/255 (26%), Positives = 112/255 (43%), Gaps = 16/255 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNPYIV 433 + LG G+FG V ++ + AVK++ K + K+ LL E +++QLD+P I+ Sbjct: 38 RVLGKGSFGEVILCKDKI--TGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIM 95 Query: 434 RMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 ++ E + + LV E+ G L + + + + ++ QV G+ Y+ ++ VH Sbjct: 96 KLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVH 155 Query: 493 RDLAARNVLL---VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 RDL N+LL +I DFGLS A K + APE ++ + Sbjct: 156 RDLKPENLLLESKSKDANIRIIDFGLSTHFEAS----KKMKDKIGTAYYIAPEVLHGT-Y 210 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE---RMGCPAGCPREMYDLMN 606 K DVWS GV+++ S G P+ G ++ +EKG+ + DL+ Sbjct: 211 DEKCDVWSTGVILYILLS-GCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIR 269 Query: 607 LCWTYDVENRPGFAA 621 TY R Sbjct: 270 KMLTYVPSMRISARD 284 >2HAK-A nrPDB Length = 328 Score = 256 bits (653), Expect = 3e-68, Method: Composition-based stats. Identities = 68/217 (31%), Positives = 104/217 (47%), Gaps = 9/217 (4%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K +G GNF VK + + + VAVKI+ +P +L E +M+ L++P IV+ Sbjct: 21 KTIGKGNFAKVKLARHVL--TGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVK 78 Query: 435 MIGICEAE-SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + + E E + LVME A G + YL + +K+K Q+ ++Y + VHR Sbjct: 79 LFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHR 138 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS-SK 552 DL A N+LL KI+DFG S K T P + APE K+ + Sbjct: 139 DLKAENLLLDGDMNIKIADFGFSNEFTVGN---KLDTFCGSPP-YAAPELFQGKKYDGPE 194 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 DVWS GV+++ S G P+ G E+ + +G+ Sbjct: 195 VDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRGK 230 >5X5O-A nrPDB Length = 310 Score = 254 bits (649), Expect = 7e-68, Method: Composition-based stats. Identities = 79/263 (30%), Positives = 126/263 (47%), Gaps = 25/263 (9%) Query: 378 GSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIG 437 G G+FG+V + + + K VAVK L + EA ++ L + I++ G Sbjct: 24 GGGSFGSVYRAKWISQD--KEVAVKKLLK----------IEKEAEILSVLSHRNIIQFYG 71 Query: 438 IC-EAESWMLVMEMAELGPLNKYLQQNRH--VKDKNIIELVHQVSMGMKYLEES---NFV 491 + E ++ +V E A LG L Y+ NR + +I+ V+ GM YL + Sbjct: 72 VILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVI 131 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 HRDL +RNV++ KI DFG S+ + T W APE I S Sbjct: 132 HRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTF-----PWMAPEVIQSLPVSE 186 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAML-EKGERMGCPAGCPREMYDLMNLCWT 610 D +S+GV++WE + + P++G++G +V ++ EK ER+ P+ CPR +L++ CW Sbjct: 187 TCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWE 245 Query: 611 YDVENRPGFAAVELRLRNYYYDV 633 D + RP F + L + D Sbjct: 246 ADAKKRPSFKQIISILESMSNDT 268 >5EZV-A nrPDB Length = 560 Score = 254 bits (648), Expect = 1e-67, Method: Composition-based stats. Identities = 70/276 (25%), Positives = 116/276 (42%), Gaps = 12/276 (4%) Query: 353 ADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDP 411 DP E + + + L D LG G FG VK G +Q+ VAVKIL + + Sbjct: 13 QDPAEKQKHDGRVKIGHYVLGD-TLGVGTFGKVKIGEHQL--TGHKVAVKILNRQKIRSL 69 Query: 412 ALKDELLAEANVMQQLDNPYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKN 470 + ++ E ++ +P+I+++ + + + +VME G L Y+ ++ V++ Sbjct: 70 DVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEME 129 Query: 471 IIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQT 530 L Q+ + Y VHRDL NVLL AKI+DFGLS + E +T Sbjct: 130 ARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE---FLRT 186 Query: 531 HGKWPVKWYAPECINYYKF-SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 P + APE I+ + + D+WS GV+++ G P+ + + +G Sbjct: 187 SCGSP-NYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGG 243 Query: 590 RMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELR 625 P R + L+ D R + Sbjct: 244 VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREH 279 >2BDW-A nrPDB Length = 362 Score = 253 bits (645), Expect = 2e-67, Method: Composition-based stats. Identities = 54/254 (21%), Positives = 105/254 (41%), Gaps = 14/254 (5%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +ELG G F V++ + K A KI+ + +L EA + ++L +P IVR Sbjct: 35 EELGKGAFSVVRRCVH--KTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVR 92 Query: 435 MIGICEAESW-MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + + ES+ LV ++ G L + + + + + Q+ + Y + VHR Sbjct: 93 LHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIVHR 152 Query: 494 DLAARNVLLVTQHY---AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 +L N+LL ++ K++DFGL+ + E ++ + +PE + +S Sbjct: 153 NLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWH----GFAGTPGYLSPEVLKKDPYS 208 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG---ERMGCPAGCPREMYDLMNL 607 D+W+ GV+++ G P+ + A ++ G E L++ Sbjct: 209 KPVDIWACGVILYILL-VGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDS 267 Query: 608 CWTYDVENRPGFAA 621 T + + R Sbjct: 268 MLTVNPKKRITADQ 281 >6C9D-A nrPDB Length = 459 Score = 252 bits (644), Expect = 3e-67, Method: Composition-based stats. Identities = 67/217 (30%), Positives = 103/217 (47%), Gaps = 9/217 (4%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K +G GNF VK + + + VAVKI+ +P +L E +M+ L++P IV+ Sbjct: 27 KTIGKGNFAKVKLARHVL--TGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVK 84 Query: 435 MIGICEAE-SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + + E E + LVME A G + YL + +K+K Q+ ++Y + VHR Sbjct: 85 LFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHR 144 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS-SK 552 DL A N+LL KI+DFG S K P + APE K+ + Sbjct: 145 DLKAENLLLDGDMNIKIADFGFSNEFTVGN---KLDEFCGSPP-YAAPELFQGKKYDGPE 200 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 DVWS GV+++ S G P+ G E+ + +G+ Sbjct: 201 VDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRGK 236 >4CFF-A nrPDB Length = 571 Score = 252 bits (644), Expect = 3e-67, Method: Composition-based stats. Identities = 65/253 (25%), Positives = 108/253 (42%), Gaps = 11/253 (4%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNPYIVR 434 LG G FG VK G +Q+ VAVKIL + + + ++ E ++ +P+I++ Sbjct: 40 TLGVGTFGKVKIGEHQL--TGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIK 97 Query: 435 MIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + + + + +VME G L Y+ ++ V++ L Q+ + Y VHR Sbjct: 98 LYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHR 157 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF-SSK 552 DL NVLL AKI+DFGLS + E +T P + APE I+ + + Sbjct: 158 DLKPENVLLDAHMNAKIADFGLSNMMSDGE---FLRTSCGSP-NYAAPEVISGRLYAGPE 213 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYD 612 D+WS GV+++ G P+ + + +G P R + L+ D Sbjct: 214 VDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLNRSVATLLMHMLQVD 271 Query: 613 VENRPGFAAVELR 625 R + Sbjct: 272 PLKRATIKDIREH 284 >4CZT-A nrPDB Length = 464 Score = 252 bits (643), Expect = 4e-67, Method: Composition-based stats. Identities = 61/255 (23%), Positives = 103/255 (40%), Gaps = 8/255 (3%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEA-NDPALKDELLAEANVMQQLDNPYI 432 + LG G F VK VA+K++ E + ++ E + M+ + +P + Sbjct: 16 GRTLGEGTFAKVKFARNVEN--GDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNV 73 Query: 433 VRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFV 491 +RM + +++ V+E G L + N +K+ + Q+ + Y Sbjct: 74 IRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVY 133 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS- 550 HRDL N+LL K+SDFGLS + T P + APE IN + Sbjct: 134 HRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP-NYVAPEVINNKGYDG 192 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWT 610 +K+D+WS GV+++ + G P+ + + + K E CP L+ Sbjct: 193 AKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAE-FTCPPWFSASAKKLIKRILD 250 Query: 611 YDVENRPGFAAVELR 625 + R FA V Sbjct: 251 PNPATRITFAEVIEN 265 >4L42-A nrPDB Length = 346 Score = 251 bits (642), Expect = 5e-67, Method: Composition-based stats. Identities = 65/277 (23%), Positives = 116/277 (41%), Gaps = 17/277 (6%) Query: 347 VYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGY-YQMKKVVKTVAVKILK 405 S PE+IRP+ L R LG G +G V + K A+K+LK Sbjct: 4 SETSVNRGPEKIRPECFELLR--------VLGKGGYGKVFQVRKVTGANTGKIFAMKVLK 55 Query: 406 NEA--NDPALKDELLAEANVMQQLDNPYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQ 462 + AE N+++++ +P+IV +I + L++E G L L++ Sbjct: 56 KAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLER 115 Query: 463 NRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRAD 522 + + ++SM + +L + ++RDL N++L Q + K++DFGL K D Sbjct: 116 EGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHD 175 Query: 523 ENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVT 582 +++ APE + + D WS G LM++ + G P+ G + Sbjct: 176 GTVTHT---FCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLT-GAPPFTGENRKKTI 231 Query: 583 AMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGF 619 + K + + P +E DL+ + +R G Sbjct: 232 DKILKCK-LNLPPYLTQEARDLLKKLLKRNAASRLGA 267 >3KK8-A nrPDB Length = 284 Score = 251 bits (642), Expect = 6e-67, Method: Composition-based stats. Identities = 54/254 (21%), Positives = 105/254 (41%), Gaps = 14/254 (5%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +ELG G F V++ + K A KI+ + +L EA + ++L +P IVR Sbjct: 12 EELGKGAFSVVRRCVH--KTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVR 69 Query: 435 MIGICEAESW-MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + + ES+ LV ++ G L + + + + + Q+ + Y + VHR Sbjct: 70 LHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIVHR 129 Query: 494 DLAARNVLLVTQHY---AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 +L N+LL ++ K++DFGL+ + E ++ + +PE + +S Sbjct: 130 NLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWH----GFAGTPGYLSPEVLKKDPYS 185 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG---ERMGCPAGCPREMYDLMNL 607 D+W+ GV+++ G P+ + A ++ G E L++ Sbjct: 186 KPVDIWACGVILYILL-VGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDS 244 Query: 608 CWTYDVENRPGFAA 621 T + + R Sbjct: 245 MLTVNPKKRITADQ 258 >5FG8-A nrPDB Length = 285 Score = 251 bits (640), Expect = 1e-66, Method: Composition-based stats. Identities = 54/254 (21%), Positives = 105/254 (41%), Gaps = 13/254 (5%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +ELG G F VK+ K A KI+ + +L EA + ++L +P IVR Sbjct: 20 EELGKGAFSIVKRCV--QKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVR 77 Query: 435 MIGICEAESW-MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + + E++ LV ++ G L + + + + + Q+ + + ++ VHR Sbjct: 78 LHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHR 137 Query: 494 DLAARNVLLVTQHY---AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 DL N+LL ++ K++DFGL+ ++ D + + +PE + + Sbjct: 138 DLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWF---GFAGTPGYLSPEVLKKEPYG 194 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG---ERMGCPAGCPREMYDLMNL 607 D+W+ GV+++ G P+ + + ++ G E +L+N Sbjct: 195 KSVDIWACGVILYILL-VGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQ 253 Query: 608 CWTYDVENRPGFAA 621 T + R A Sbjct: 254 MLTVNPNKRITAAE 267 >3COM-A nrPDB Length = 314 Score = 251 bits (640), Expect = 1e-66, Method: Composition-based stats. Identities = 72/304 (23%), Positives = 132/304 (43%), Gaps = 29/304 (9%) Query: 326 ELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTV 385 L P+R+ +D + PEE+ ++LG G++G+V Sbjct: 1 SLETVQLRNPPRRQLKKLDEDSLTK---QPEEVFDV------------LEKLGEGSYGSV 45 Query: 386 KKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIG-ICEAESW 444 K + K+ + VA+K + E++ E++ E ++MQQ D+P++V+ G + Sbjct: 46 YKAIH--KETGQIVAIKQVPVESD----LQEIIKEISIMQQCDSPHVVKYYGSYFKNTDL 99 Query: 445 MLVMEMAELGPLNKYLQ-QNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV 503 +VME G ++ ++ +N+ + + I ++ G++YL +HRD+ A N+LL Sbjct: 100 WIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLN 159 Query: 504 TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMW 563 T+ +AK++DFG++ L + K T P W APE I ++ +D+WS G+ Sbjct: 160 TEGHAKLADFGVAGQLT--DTMAKRNTVIGTPF-WMAPEVIQEIGYNCVADIWSLGITAI 216 Query: 564 EAFSYGQKPYRGMKGSEVTAMLEKGERMGC--PAGCPREMYDLMNLCWTYDVENRPGFAA 621 E + G+ PY + M+ P D + C E R Sbjct: 217 EM-AEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQ 275 Query: 622 VELR 625 + Sbjct: 276 LLQH 279 >4FIE-A nrPDB Length = 423 Score = 250 bits (638), Expect = 2e-66, Method: Composition-based stats. Identities = 66/321 (20%), Positives = 120/321 (37%), Gaps = 26/321 (8%) Query: 308 PAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDR 367 P RQE+ + P P + PQRE + E + + + YLD Sbjct: 104 PPARARQENGMPEKPPGP--------RSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDN 155 Query: 368 KLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL 427 + ++G G+ G V ++ K VAVK + + ++ L E +M+ Sbjct: 156 FI------KIGEGSTGIV--CIATVRSSGKLVAVKKM--DLRKQQRRELLFNEVVIMRDY 205 Query: 428 DNPYIVRMIGICE-AESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE 486 + +V M + +VME E G L + + + ++ I + V + L Sbjct: 206 QHENVVEMYNSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLH 264 Query: 487 ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY 546 +HRD+ + ++LL K+SDFG + + K+ W APE I+ Sbjct: 265 AQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLV---GTPYWMAPELISR 321 Query: 547 YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE--RMGCPAGCPREMYDL 604 + + D+WS G+++ E G+ PY + M+ R+ + Sbjct: 322 LPYGPEVDIWSLGIMVIEMV-DGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGF 380 Query: 605 MNLCWTYDVENRPGFAAVELR 625 ++ D R A + Sbjct: 381 LDRLLVRDPAQRATAAELLKH 401 >2YZA-A nrPDB Length = 276 Score = 249 bits (637), Expect = 2e-66, Method: Composition-based stats. Identities = 63/253 (24%), Positives = 106/253 (41%), Gaps = 11/253 (4%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNPYIVR 434 LG G FG VK G +Q+ VAVKIL + + + ++ E ++ +P+I++ Sbjct: 18 TLGVGTFGKVKIGEHQL--TGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIK 75 Query: 435 MIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + + + + +VME G L Y+ ++ V++ L Q+ + Y VHR Sbjct: 76 LYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHR 135 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF-SSK 552 DL NVLL AKI+DFGLS + E + + APE I+ + + Sbjct: 136 DLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDS----CGSPNYAAPEVISGRLYAGPE 191 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYD 612 D+WS GV+++ G P+ + + +G P R + L+ D Sbjct: 192 VDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLNRSVATLLMHMLQVD 249 Query: 613 VENRPGFAAVELR 625 R + Sbjct: 250 PLKRATIKDIREH 262 >3MN3-A nrPDB Length = 271 Score = 249 bits (637), Expect = 2e-66, Method: Composition-based stats. Identities = 60/259 (23%), Positives = 111/259 (42%), Gaps = 14/259 (5%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNPYIV 433 K LG G+FG VK Y+ + VA+KI+ K ++ + E + ++ L +P+I+ Sbjct: 10 KTLGEGSFGKVKLAYH--TTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHII 67 Query: 434 RMIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 ++ + ++ + ++V+E A L Y+ Q + ++ Q+ ++Y VH Sbjct: 68 KLYDVIKSKDEIIMVIEYA-GNELFDYIVQRDKMSEQEARRFFQQIISAVEYCHRHKIVH 126 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF-SS 551 RDL N+LL KI+DFGLS + D N+ K + APE I+ + Sbjct: 127 RDLKPENLLLDEHLNVKIADFGLS-NIMTDGNFLKTSC---GSPNYAAPEVISGKLYAGP 182 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 611 + DVWS GV+++ + P+ + + G P L+ Sbjct: 183 EVDVWSCGVILYVMLCR-RLPFDDESIPVLFKNISNG-VYTLPKFLSPGAAGLIKRMLIV 240 Query: 612 DVENRPGFAAVELRLRNYY 630 + NR + +++ Sbjct: 241 NPLNRISIHEIMQ--DDWF 257 >4QMW-A nrPDB Length = 310 Score = 249 bits (635), Expect = 3e-66, Method: Composition-based stats. Identities = 66/261 (25%), Positives = 119/261 (45%), Gaps = 9/261 (3%) Query: 366 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 425 D + L + +++G G+FG V KG + K VA+KI+ E + ++D E V+ Sbjct: 26 DPEELFTKLEKIGKGSFGEVFKGIDN--RTQKVVAIKIIDLEEAEDEIEDI-QQEITVLS 82 Query: 426 QLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKY 484 Q D+PY+ + G ++ + ++ME G L + + + I ++ ++ G+ Y Sbjct: 83 QCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLL-EPGPLDETQIATILREILKGLDY 141 Query: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 L +HRD+ A NVLL K++DFG++ L + K T P W APE I Sbjct: 142 LHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLT--DTQIKRNTFVGTPF-WMAPEVI 198 Query: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDL 604 + SK+D+WS G+ E + G+ P+ + +V ++ K + + + Sbjct: 199 KQSAYDSKADIWSLGITAIE-LARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEF 257 Query: 605 MNLCWTYDVENRPGFAAVELR 625 + C + RP + Sbjct: 258 VEACLNKEPSFRPTAKELLKH 278 >4D28-A nrPDB Length = 446 Score = 249 bits (635), Expect = 4e-66, Method: Composition-based stats. Identities = 56/253 (22%), Positives = 106/253 (41%), Gaps = 10/253 (3%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNPYI 432 + +G G F VK + VA+KI+ K+ + D++ E ++M+ + +P I Sbjct: 14 GRTIGEGTFAKVKFA--RNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNI 71 Query: 433 VRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFV 491 VR+ + ++S +V+E G L + +K+ + Q+ + + Sbjct: 72 VRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHCHSKGVY 131 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS- 550 HRDL N+LL T K+SDFGLS + + APE ++ + Sbjct: 132 HRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELL---NDTCGTPNYVAPEVLSGQGYDG 188 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWT 610 S +D+WS GV+++ + G P+ + + E CP E+ L++ Sbjct: 189 SAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAE-FDCPPWFSAEVKFLIHRILD 246 Query: 611 YDVENRPGFAAVE 623 + + R ++ Sbjct: 247 PNPKTRIQIQGIK 259 >5X3F-B nrPDB Length = 393 Score = 249 bits (635), Expect = 4e-66, Method: Composition-based stats. Identities = 67/297 (22%), Positives = 131/297 (44%), Gaps = 24/297 (8%) Query: 341 LPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVA 400 L E + + P + + DR K LG+G+FG V + K+ A Sbjct: 62 LAKAKEDFLKKWETPSQNTAQLDQFDRI------KTLGTGSFGRVMLVKH--KESGNHYA 113 Query: 401 VKIL-KNEANDPALKDELLAEANVMQQLDNPYIVRM-IGICEAESWMLVMEMAELGPLNK 458 +KIL K + + L E ++Q ++ P++V++ + + +VME G + Sbjct: 114 MKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFS 173 Query: 459 YLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKA 518 +L++ + + Q+ + +YL + ++RDL N+L+ Q Y +++DFG +K Sbjct: 174 HLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR 233 Query: 519 LRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKG 578 ++ + T P ++ APE I ++ D W+ GVL++E + G P+ + Sbjct: 234 VKG-----RTWTLCGTP-EYLAPEIILSKGYNKAVDWWALGVLIYEM-AAGYPPFFADQP 286 Query: 579 SEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 ++ + G+ P+ ++ DL+ D+ R G L+N D+ N Sbjct: 287 IQIYEKIVSGKV-RFPSHFSSDLKDLLRNLLQVDLTKRFG------NLKNGVNDIKN 336 >4RED-A nrPDB Length = 351 Score = 248 bits (634), Expect = 4e-66, Method: Composition-based stats. Identities = 66/257 (25%), Positives = 107/257 (41%), Gaps = 11/257 (4%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNP 430 + LG G FG VK G +++ VAVKIL + + + ++ E ++ +P Sbjct: 17 ILGDTLGVGTFGKVKVGKHEL--TGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHP 74 Query: 431 YIVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 +I+++ + S +VME G L Y+ +N + +K L Q+ G+ Y Sbjct: 75 HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM 134 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 VHRDL NVLL AKI+DFGLS + E +T P + APE I+ + Sbjct: 135 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE---FLRTSCGSP-NYAAPEVISGRLY 190 Query: 550 -SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLC 608 + D+WS GV+++ G P+ + + G P + L+ Sbjct: 191 AGPEVDIWSSGVILYALLC-GTLPFDDDHVPTLFKKICDGI-FYTPQYLNPSVISLLKHM 248 Query: 609 WTYDVENRPGFAAVELR 625 D R + Sbjct: 249 LQVDPMKRASIKDIREH 265 >4REW-A nrPDB Length = 540 Score = 248 bits (634), Expect = 5e-66, Method: Composition-based stats. Identities = 66/257 (25%), Positives = 107/257 (41%), Gaps = 11/257 (4%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNP 430 + LG G FG VK G +++ VAVKIL + + + ++ E ++ +P Sbjct: 9 ILGDTLGVGTFGKVKVGKHEL--TGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHP 66 Query: 431 YIVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 +I+++ + S +VME G L Y+ +N + +K L Q+ G+ Y Sbjct: 67 HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM 126 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 VHRDL NVLL AKI+DFGLS + E +T P + APE I+ + Sbjct: 127 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE---FLRTSCGSP-NYAAPEVISGRLY 182 Query: 550 -SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLC 608 + D+WS GV+++ G P+ + + G P + L+ Sbjct: 183 AGPEVDIWSSGVILYALLC-GTLPFDDDHVPTLFKKICDGI-FYTPQYLNPSVISLLKHM 240 Query: 609 WTYDVENRPGFAAVELR 625 D R + Sbjct: 241 LQVDPMKRASIKDIREH 257 >4RLP-A nrPDB Length = 288 Score = 248 bits (633), Expect = 6e-66, Method: Composition-based stats. Identities = 57/249 (22%), Positives = 107/249 (42%), Gaps = 9/249 (3%) Query: 375 KELGSGNFGTVKKGY-YQMKKVVKTVAVKILKNEA--NDPALKDELLAEANVMQQLDNPY 431 + LG G +G V + K A+K+LK + AE N+++++ +P+ Sbjct: 11 RVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPF 70 Query: 432 IVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 IV +I + L++E G L L++ + + ++SM + +L + Sbjct: 71 IVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGI 130 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 ++RDL N++L Q + K++DFGL K D +++ APE + + Sbjct: 131 IYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHT---FCGTIEYMAPEILMRSGHN 187 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWT 610 D WS G LM++ + G P+ G + + K + + P +E DL+ Sbjct: 188 RAVDWWSLGALMYDMLT-GAPPFTGENRKKTIDKILKCK-LNLPPYLTQEARDLLKKLLK 245 Query: 611 YDVENRPGF 619 + +R G Sbjct: 246 RNAASRLGA 254 >2V7O-A nrPDB Length = 336 Score = 248 bits (633), Expect = 6e-66, Method: Composition-based stats. Identities = 53/254 (20%), Positives = 107/254 (42%), Gaps = 13/254 (5%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +ELG G F V++ K + A KI+ + +L EA + + L +P IVR Sbjct: 37 EELGKGAFSVVRRCV--KKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVR 94 Query: 435 MIGICEAESW-MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + E + LV ++ G L + + + + + +HQ+ + ++ + + VHR Sbjct: 95 LHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHR 154 Query: 494 DLAARNVLLVTQHY---AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 DL N+LL ++ K++DFGL+ ++ ++ + + +PE + + Sbjct: 155 DLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWF---GFAGTPGYLSPEVLRKDPYG 211 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG-ERMGCP--AGCPREMYDLMNL 607 D+W+ GV+++ G P+ ++ ++ G P E +L+N Sbjct: 212 KPVDIWACGVILYILL-VGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQ 270 Query: 608 CWTYDVENRPGFAA 621 T + R Sbjct: 271 MLTINPAKRITADQ 284 >4WB7-A nrPDB Length = 405 Score = 248 bits (632), Expect = 8e-66, Method: Composition-based stats. Identities = 72/329 (21%), Positives = 138/329 (41%), Gaps = 23/329 (6%) Query: 314 QESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLE 373 +E E A +RE E + A +E K+ + Sbjct: 36 KEPGAEEKFKEIAEAYDVLSDPRKREIFDRYGEEVKEFLAKAKEDFLKKWESPAQNTAHL 95 Query: 374 D-----KELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQL 427 D K LG+G+FG V + K+ A+KIL K + + L E ++Q + Sbjct: 96 DQFERIKTLGTGSFGRVMLVKH--KETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAV 153 Query: 428 DNPYIVRM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE 486 + P++V++ + + +VME G + +L++ + + Q+ + +YL Sbjct: 154 NFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 213 Query: 487 ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY 546 + ++RDL N+L+ Q Y +++DFG +K ++ + T P ++ APE I Sbjct: 214 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG-----RTWTLCGTP-EYLAPEIILS 267 Query: 547 YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMN 606 ++ D W+ GVL++E + G P+ + ++ + G+ P+ ++ DL+ Sbjct: 268 KGYNKAVDWWALGVLIYEM-AAGYPPFFADQPIQIYEKIVSGKV-RFPSHFSSDLKDLLR 325 Query: 607 LCWTYDVENRPGFAAVELRLRNYYYDVVN 635 D+ R G L+N D+ N Sbjct: 326 NLLQVDLTKRFG------NLKNGVNDIKN 348 >3LMG-A nrPDB Length = 344 Score = 248 bits (632), Expect = 8e-66, Method: Composition-based stats. Identities = 96/277 (34%), Positives = 156/277 (56%), Gaps = 6/277 (2%) Query: 354 DPEEIRPKEVYLDRKLLTLED-KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEAND 410 DP E K + K L K LGSG FGTV KG + + + + V +K++++++ Sbjct: 15 DPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGR 74 Query: 411 PALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRH-VKDK 469 + + + LD+ +IVR++G+C S LV + LG L +++Q+R + + Sbjct: 75 QSF-QAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQ 133 Query: 470 NIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQ 529 ++ Q++ GM YLEE VHR+LAARNVLL + +++DFG++ L D + Sbjct: 134 LLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPD-DKQLLY 192 Query: 530 THGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 + K P+KW A E I++ K++ +SDVWS+GV +WE ++G +PY G++ +EV +LEKGE Sbjct: 193 SEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGE 252 Query: 590 RMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 626 R+ P C ++Y +M CW D RP F + Sbjct: 253 RLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEF 289 >2VN9-A nrPDB Length = 301 Score = 248 bits (632), Expect = 9e-66, Method: Composition-based stats. Identities = 53/254 (20%), Positives = 103/254 (40%), Gaps = 13/254 (5%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +ELG G F V++ + A KI+ + +L EA + + L +P IVR Sbjct: 10 EELGKGAFSVVRRCM--KIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVR 67 Query: 435 MIGICEAESW-MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + E + LV ++ G L + + + + + + Q+ + + + VHR Sbjct: 68 LHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHR 127 Query: 494 DLAARNVLLVTQHY---AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 DL N+LL ++ K++DFGL+ ++ D+ + + +PE + + Sbjct: 128 DLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWF---GFAGTPGYLSPEVLRKDPYG 184 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG-ERMGCP--AGCPREMYDLMNL 607 D+W+ GV+++ G P+ + ++ G P E DL+N Sbjct: 185 KPVDMWACGVILYILL-VGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 243 Query: 608 CWTYDVENRPGFAA 621 T + R + Sbjct: 244 MLTINPAKRITASE 257 >3H4J-B nrPDB Length = 336 Score = 247 bits (630), Expect = 1e-65, Method: Composition-based stats. Identities = 57/257 (22%), Positives = 105/257 (40%), Gaps = 12/257 (4%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKD-ELLAEANVMQQLDNP 430 + + LG G+FG VK + K + VA+K + + + + E + ++ L +P Sbjct: 12 IIRETLGEGSFGKVKLATHY--KTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHP 69 Query: 431 YIVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 +I+++ + + ++V+E A G L Y+ + + + + Q+ ++Y Sbjct: 70 HIIKLYDVITTPTDIVMVIEYA-GGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHRHK 128 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 VHRDL N+LL KI+DFGLS + D N+ K + APE IN + Sbjct: 129 IVHRDLKPENLLLDDNLNVKIADFGLS-NIMTDGNFLKTSC---GSPNYAAPEVINGKLY 184 Query: 550 -SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLC 608 + DVWS G++++ G+ P+ + + P L+ Sbjct: 185 AGPEVDVWSCGIVLYVML-VGRLPFDDEFIPNLFKKVNSC-VYVMPDFLSPGAQSLIRRM 242 Query: 609 WTYDVENRPGFAAVELR 625 D R + Sbjct: 243 IVADPMQRITIQEIRRD 259 >4JDH-A nrPDB Length = 346 Score = 246 bits (628), Expect = 2e-65, Method: Composition-based stats. Identities = 65/319 (20%), Positives = 119/319 (37%), Gaps = 26/319 (8%) Query: 310 QGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKL 369 RQE+ + P P + PQRE + E + + + YLD + Sbjct: 29 ARARQENGMPEKPPGP--------RSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI 80 Query: 370 LTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDN 429 ++G G+ G V ++ K VAVK + + ++ L E +M+ + Sbjct: 81 ------KIGEGSTGIV--CIATVRSSGKLVAVKKM--DLRKQQRRELLFNEVVIMRDYQH 130 Query: 430 PYIVRMIGICE-AESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 +V M + +VME E G L + + + ++ I + V + L Sbjct: 131 ENVVEMYNSYLVGDELWVVMEFLEGGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQ 189 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 +HRD+ + ++LL K+SDFG + + K+ W APE I+ Sbjct: 190 GVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLV---GTPYWMAPELISRLP 246 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE--RMGCPAGCPREMYDLMN 606 + + D+WS G+++ E G+ PY + M+ R+ + ++ Sbjct: 247 YGPEVDIWSLGIMVIEMV-DGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLD 305 Query: 607 LCWTYDVENRPGFAAVELR 625 D R A + Sbjct: 306 RLLVRDPAQRATAAELLKH 324 >4CFH-A nrPDB Length = 493 Score = 246 bits (628), Expect = 2e-65, Method: Composition-based stats. Identities = 66/257 (25%), Positives = 107/257 (41%), Gaps = 11/257 (4%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNP 430 + LG G FG VK G +++ VAVKIL + + + ++ E ++ +P Sbjct: 36 ILGDTLGVGTFGKVKVGKHEL--TGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHP 93 Query: 431 YIVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 +I+++ + S +VME G L Y+ +N + +K L Q+ G+ Y Sbjct: 94 HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM 153 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 VHRDL NVLL AKI+DFGLS + E +T P + APE I+ + Sbjct: 154 VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE---FLRTSCGSP-NYAAPEVISGRLY 209 Query: 550 -SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLC 608 + D+WS GV+++ G P+ + + G P + L+ Sbjct: 210 AGPEVDIWSSGVILYALLC-GTLPFDDDHVPTLFKKICDGI-FYTPQYLNPSVISLLKHM 267 Query: 609 WTYDVENRPGFAAVELR 625 D R + Sbjct: 268 LQVDPMKRATIKDIREH 284 >5N23-A nrPDB Length = 352 Score = 246 bits (627), Expect = 3e-65, Method: Composition-based stats. Identities = 66/300 (22%), Positives = 131/300 (43%), Gaps = 23/300 (7%) Query: 338 REALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVK 397 +E L E + + P + +R + LG+G+FG V + K+ Sbjct: 17 KEFLAKAKEDFLKKWESPAQNTAHLDQFERI------RTLGTGSFGRVMLVKH--KETGN 68 Query: 398 TVAVKIL-KNEANDPALKDELLAEANVMQQLDNPYIVRM-IGICEAESWMLVMEMAELGP 455 A+KIL K + + L E + Q ++ P++V++ + + +V+E A G Sbjct: 69 HYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNFPFLVKLEFSFKDNSNLYMVLEYAPGGE 128 Query: 456 LNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGL 515 + +L++ + + Q+ + +YL + ++RDL N+L+ Q Y K++DFG Sbjct: 129 MFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGF 188 Query: 516 SKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG 575 +K ++ + T ++ APE I ++ D W+ GVL++E + G P+ Sbjct: 189 AKRVKGRTPWTLCGT-----PEYLAPEIILSKGYNKAVDWWALGVLIYEM-AAGYPPFFA 242 Query: 576 MKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 + ++ + G+ P+ ++ DL+ D+ R G L+N D+ N Sbjct: 243 DQPIQIYEKIVSGKV-RFPSHFSSDLKDLLRNLLQVDLTKRFG------NLKNGVNDIKN 295 >3KN6-A nrPDB Length = 325 Score = 246 bits (627), Expect = 3e-65, Method: Composition-based stats. Identities = 64/275 (23%), Positives = 118/275 (42%), Gaps = 26/275 (9%) Query: 364 YLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANV 423 + L L+DK LG G+F +K + KK + AVKI+ K E Sbjct: 6 FYQHYDLDLKDKPLGEGSFSICRKCVH--KKSNQAFAVKIISKRMEANTQK-----EITA 58 Query: 424 MQQLD-NPYIVRMIGICEAESW-MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMG 481 ++ + +P IV++ + + LVME+ G L + +++ +H + ++ ++ Sbjct: 59 LKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSA 118 Query: 482 MKYLEESNFVHRDLAARNVLLVTQH---YAKISDFGLSKALRADENYYKAQTHGKWPVKW 538 + ++ + VHRDL N+L ++ KI DFG ++ D K + + + Sbjct: 119 VSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPC---FTLHY 175 Query: 539 YAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGS-------EVTAMLEKGERM 591 APE +N + D+WS GV+++ S GQ P++ S E+ ++KG+ Sbjct: 176 AAPELLNQNGYDESCDLWSLGVILYTMLS-GQVPFQSHDRSLTCTSAVEIMKKIKKGDFS 234 Query: 592 ---GCPAGCPREMYDLMNLCWTYDVENRPGFAAVE 623 +E DL+ T D R + + Sbjct: 235 FEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLR 269 >5U6Y-A nrPDB Length = 461 Score = 245 bits (626), Expect = 4e-65, Method: Composition-based stats. Identities = 53/254 (20%), Positives = 103/254 (40%), Gaps = 13/254 (5%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +ELG G F V++ + + A KI+ + +L EA + + L +P IVR Sbjct: 6 EELGKGAFSVVRRCVKVL--AGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVR 63 Query: 435 MIG-ICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + I E L+ ++ G L + + + + + + Q+ + + + VHR Sbjct: 64 LHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHR 123 Query: 494 DLAARNVLLVTQHY---AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 DL N+LL ++ K++DFGL+ + ++ + + +PE + + Sbjct: 124 DLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWF---GFAGTPGYLSPEVLRKDPYG 180 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG-ERMGCP--AGCPREMYDLMNL 607 D+W+ GV+++ G P+ + ++ G P E DL+N Sbjct: 181 KPVDLWACGVILYILL-VGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 239 Query: 608 CWTYDVENRPGFAA 621 T + R A Sbjct: 240 MLTINPSKRITAAE 253 >2VZ6-A nrPDB Length = 313 Score = 245 bits (625), Expect = 5e-65, Method: Composition-based stats. Identities = 53/254 (20%), Positives = 103/254 (40%), Gaps = 13/254 (5%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +ELG G F V++ + + A KI+ + +L EA + + L +P IVR Sbjct: 28 EELGKGAFSVVRRCVKVL--AGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVR 85 Query: 435 MIG-ICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + I E L+ ++ G L + + + + + + Q+ + + + VHR Sbjct: 86 LHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHR 145 Query: 494 DLAARNVLLVTQHY---AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 DL N+LL ++ K++DFGL+ + ++ + + +PE + + Sbjct: 146 DLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWF---GFAGTPGYLSPEVLRKDPYG 202 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG-ERMGCP--AGCPREMYDLMNL 607 D+W+ GV+++ G P+ + ++ G P E DL+N Sbjct: 203 KPVDLWACGVILYILL-VGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 261 Query: 608 CWTYDVENRPGFAA 621 T + R A Sbjct: 262 MLTINPSKRITAAE 275 >4RGJ-A nrPDB Length = 520 Score = 244 bits (624), Expect = 7e-65, Method: Composition-based stats. Identities = 62/260 (23%), Positives = 107/260 (41%), Gaps = 17/260 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEAND-PALKDELLAEANVMQQLDNPYIV 433 K LG G+FG V K A+K++ + K+ LL E +++ LD+ I+ Sbjct: 66 KILGKGSFGEVILSRD--KHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHINIM 123 Query: 434 RMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 ++ E ++ LV ++ G L + + + + ++ Q+ G+ Y+ ++N VH Sbjct: 124 KLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMHKNNVVH 183 Query: 493 RDLAARNVLL----VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 RDL N+LL KI DFGLS Y K + AP+ ++ Sbjct: 184 RDLKPENILLETKNKEDMIIKIIDFGLSTHFE----YSKKMKDKIGTAYYIAPDVLHGT- 238 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE-RMGCPA--GCPREMYDLM 605 + K D+WS GV+++ S G P+ G ++ +E G+ P + DL+ Sbjct: 239 YDEKCDIWSCGVILYILLS-GCPPFNGSNEYDILKKVEAGKYTFDLPQFKKISDKAKDLI 297 Query: 606 NLCWTYDVENRPGFAAVELR 625 Y R Sbjct: 298 KKMLMYTSAVRISARDALEH 317 >5KCV-A nrPDB Length = 460 Score = 244 bits (623), Expect = 8e-65, Method: Composition-based stats. Identities = 74/328 (22%), Positives = 125/328 (38%), Gaps = 16/328 (4%) Query: 312 NRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLT 371 R+E T + L AA + R P D E + + + + + L Sbjct: 109 EREEWTTAIQTVADGLKKQAAAEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLK 168 Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEAN-DPALKDELLAEANVMQQLDNP 430 L LG G FG V + K + A+KILK E L E V+Q +P Sbjct: 169 L----LGKGTFGKVIL--VKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHP 222 Query: 431 YIVRM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE-S 488 ++ + + VME A G L +L + R + ++ + YL Sbjct: 223 FLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEK 282 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 N V+RDL N++L + KI+DFGL K D K ++ APE + Sbjct: 283 NVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKT---FCGTPEYLAPEVLEDND 339 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLC 608 + D W GV+M+E G+ P+ ++ ++ E + P E L++ Sbjct: 340 YGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILM-EEIRFPRTLGPEAKSLLSGL 397 Query: 609 WTYDVENRP--GFAAVELRLRNYYYDVV 634 D + R G + +++ ++ + Sbjct: 398 LKKDPKQRLGGGSEDAKEIMQHRFFAGI 425 >4YNZ-A nrPDB Length = 342 Score = 244 bits (623), Expect = 9e-65, Method: Composition-based stats. Identities = 58/255 (22%), Positives = 115/255 (45%), Gaps = 10/255 (3%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 +K LG G G VK G + + + VA+KI+ E ++ ++ E +++ +++P+++ Sbjct: 15 EKTLGKGQTGLVKLGIHCV--TCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVL 72 Query: 434 RMIGICEAESW-MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 ++ + E + + LV+E G L YL + + K + Q+ + + + H Sbjct: 73 KLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICH 132 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS-S 551 RDL N+LL ++ +I+DFG++ D +T P + PE I K+ Sbjct: 133 RDLKPENLLLDERNNIRIADFGMASLQVGDS---LLETSCGSP-HYACPEVIRGEKYDGR 188 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 611 K+DVWS GV+++ G P+ ++ +++G P P + L+ Sbjct: 189 KADVWSCGVILFALL-VGALPFDDDNLRQLLEKVKRG-VFHMPHFIPPDCQSLLRGMIEV 246 Query: 612 DVENRPGFAAVELRL 626 D R ++ + Sbjct: 247 DAARRLTLEHIQKHI 261 >5HI2-A nrPDB Length = 283 Score = 244 bits (622), Expect = 1e-64, Method: Composition-based stats. Identities = 69/265 (26%), Positives = 118/265 (44%), Gaps = 21/265 (7%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 + +GSG+FGTV KG + VAVK+L P E V+++ + I+ Sbjct: 25 GQRIGSGSFGTVYKGKWHGD-----VAVKML-----TPQQLQAFKNEVGVLRKTRHVNIL 74 Query: 434 RMIGICEAESWMLVMEMAELGPLNKYLQ-QNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 +G +V + E L +L + K +I++ Q + GM YL + +H Sbjct: 75 LFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIH 134 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN---YYKF 549 RDL + N+ L + KI DFGL+ +++ + + W APE I + Sbjct: 135 RDLKSNNIFLHEDNTVKIGDFGLA-TVKSRWSGSHQFEQLSGSILWMAPEVIRMQDSNPY 193 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPYRGMKG-SEVTAMLEKGERMG----CPAGCPREMYDL 604 S +SDV++FG++++E + GQ PY + ++ M+ +G + CP+ M L Sbjct: 194 SFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRL 252 Query: 605 MNLCWTYDVENRPGFAAVELRLRNY 629 M C + RP F + + Sbjct: 253 MAECLKKKRDERPSFPRILAEIEEL 277 >2JDO-A nrPDB Length = 342 Score = 244 bits (622), Expect = 1e-64, Method: Composition-based stats. Identities = 64/282 (22%), Positives = 112/282 (39%), Gaps = 19/282 (6%) Query: 360 PKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNE-ANDPALKDELL 418 PK D L L LG G FG V + K + A+KIL+ E + Sbjct: 5 PKVTMNDFDYLKL----LGKGTFGKVIL--VREKATGRYYAMKILRKEVIIAKDEVAHTV 58 Query: 419 AEANVMQQLDNPYIVRM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQ 477 E+ V+Q +P++ + + VME A G L +L + R ++ + Sbjct: 59 TESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAE 118 Query: 478 VSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVK 537 + ++YL + V+RD+ N++L + KI+DFGL K +D K + Sbjct: 119 IVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKT---FCGTPE 175 Query: 538 WYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGC 597 + APE + + D W GV+M+E G+ P+ + ++ E + P Sbjct: 176 YLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHERLFELILM-EEIRFPRTL 233 Query: 598 PREMYDLMNLCWTYDVENR----PGFAAVELRLRNYYYDVVN 635 E L+ D + R P + + + ++ +N Sbjct: 234 SPEAKSLLAGLLKKDPKQRLGGGPS--DAKEVMEHRFFLSIN 273 >5FET-A nrPDB Length = 847 Score = 243 bits (621), Expect = 1e-64, Method: Composition-based stats. Identities = 67/324 (20%), Positives = 131/324 (40%), Gaps = 27/324 (8%) Query: 317 TVSFNPYEPELAPWAADKGPQREAL--PMDTEVYESPYADPEEIRPKEVYLDRKLLTLED 374 T S + W DK + + PM T + E ++ E+ +R Sbjct: 487 TASIISKATSVECWFVDKSVFLQIIQGPMLTHLEERIKMQDTKVEMHELETER------- 539 Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEAN-DPALKDELLAEANVMQQLDNPYIV 433 +G G FGTVK ++ K A+K + + ++ + E + + D+P+I+ Sbjct: 540 -IIGRGTFGTVKLVHH--KPTQIRYALKCVSKRSIISLNQQNNIKLEREITAENDHPFII 596 Query: 434 RMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 R++ ++ + + E+ G L +++ + + + + ++YL E N V+ Sbjct: 597 RLVRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEYLHERNIVY 656 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSK 552 RDL N+LL Q Y K+ DFG +K ++ +A T P + APE I + Sbjct: 657 RDLKPENILLDKQGYVKLIDFGCAKKIQG-----RAYTLVGTP-HYMAPEVILGKGYGCT 710 Query: 553 SDVWSFGVLMWEAFSYGQKPY--RGMKGSEVTAMLEKGERMGCPAGCP-REMYDLMNLCW 609 D+W+ GV ++E G P+ E+ + G ++ P ++ +LM Sbjct: 711 VDIWALGVCLYEFIC-GPLPFGNDQEDQLEIFRDILTG-QLTFPDYVSDQDSINLMKRLL 768 Query: 610 TYDVENRP--GFAAVELRLRNYYY 631 + R + + ++ Sbjct: 769 CRLPQGRIGCSINGFKDIKEHAFF 792 >4CQG-A nrPDB Length = 331 Score = 242 bits (619), Expect = 2e-64, Method: Composition-based stats. Identities = 53/251 (21%), Positives = 107/251 (42%), Gaps = 9/251 (3%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 + +G+G F VK + + + VA+KI+ A L + E + ++ L + +I + Sbjct: 15 ETIGTGGFAKVKLACHVL--TGEMVAIKIMDKNALGSDLP-RVKTEIDALKSLRHQHICQ 71 Query: 435 MIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + + E ++ +V+E G L Y+ + ++ + Q+ + Y+ + HR Sbjct: 72 LYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQGYAHR 131 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF-SSK 552 DL N+L H K+ DFGL + +++Y+ + + + APE I + S+ Sbjct: 132 DLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQE--CCGSLAYAAPELIQGKSYLGSE 189 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYD 612 +DVWS G+L++ G P+ + + +G+ P L+ D Sbjct: 190 ADVWSMGILLYVLMC-GFLPFDDDNVMALYKKIMRGK-YEVPKWLSPSSILLLQQMLQVD 247 Query: 613 VENRPGFAAVE 623 + R + Sbjct: 248 PKKRISMRNLL 258 >3HDN-A nrPDB Length = 373 Score = 242 bits (619), Expect = 3e-64, Method: Composition-based stats. Identities = 59/265 (22%), Positives = 114/265 (43%), Gaps = 11/265 (4%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVM-QQLDNPYI 432 K +G G+FG V ++ ++V AVK+L K + +++E NV+ + + +P++ Sbjct: 44 KVIGKGSFGKVLLARHKAEEVF--YAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFL 101 Query: 433 VRM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFV 491 V + A+ V++ G L +LQ+ R + +++ + YL N V Sbjct: 102 VGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIV 161 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 +RDL N+LL +Q + ++DFGL K E+ T P ++ APE ++ + Sbjct: 162 YRDLKPENILLDSQGHIVLTDFGLCK--ENIEHNSTTSTFCGTP-EYLAPEVLHKQPYDR 218 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 611 D W G +++E YG P+ +E+ + + + L+ Sbjct: 219 TVDWWCLGAVLYEML-YGLPPFYSRNTAEMYDNIL-NKPLQLKPNITNSARHLLEGLLQK 276 Query: 612 DVENRPGF-AAVELRLRNYYYDVVN 635 D R G + ++ ++N Sbjct: 277 DRTKRLGAKDDFMEIKSHVFFSLIN 301 >5XZW-A nrPDB Length = 471 Score = 242 bits (618), Expect = 3e-64, Method: Composition-based stats. Identities = 74/274 (27%), Positives = 120/274 (43%), Gaps = 27/274 (9%) Query: 367 RKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQ 426 K ++ D+ +G G F TVKK + KT AVKI+ D + E V+Q+ Sbjct: 194 FKDFSIIDEVVGQGAFATVKKAI--ERTTGKTFAVKIISKRKV-IGNMDGVTRELEVLQK 250 Query: 427 LDNPYIVRMIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYL 485 L++P IVR+ G E ES+ +VME G L ++ + V + E+ Q+ +KY+ Sbjct: 251 LNHPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYI 310 Query: 486 EESNFVHRDLAARNVLLVTQH--YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPEC 543 HRDL N+L+ KI+DFGL+K ++ + ++ K + + APE Sbjct: 311 HSMGISHRDLKPDNILIEQDDPVLVKITDFGLAK-VQGNGSFMKT---FCGTLAYVAPEV 366 Query: 544 INYY-------------KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGER 590 I ++SS D+WS G L++ + G P+ G ++ + +G Sbjct: 367 IRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILT-GHLPFSGSTQDQLYKQIGRGSY 425 Query: 591 MGCPA---GCPREMYDLMNLCWTYDVENRPGFAA 621 P E D ++ D NR A Sbjct: 426 HEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAK 459 >3BHH-A nrPDB Length = 295 Score = 242 bits (617), Expect = 4e-64, Method: Composition-based stats. Identities = 49/254 (19%), Positives = 101/254 (39%), Gaps = 13/254 (5%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +++G G F V++ A KI+ + +L EA + + L + IVR Sbjct: 10 EDIGKGAFSVVRRCVKLC--TGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVR 67 Query: 435 MIGICEAESW-MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + E + LV ++ G L + + + + + + Q+ + + + VHR Sbjct: 68 LHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHR 127 Query: 494 DLAARNVLLVTQHY---AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 DL N+LL ++ K++DFGL+ ++ D+ + + +PE + + Sbjct: 128 DLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWF---GFAGTPGYLSPEVLRKEAYG 184 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG-ERMGCP--AGCPREMYDLMNL 607 D+W+ GV+++ G P+ ++ ++ G P E +L+N Sbjct: 185 KPVDIWACGVILYILL-VGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQ 243 Query: 608 CWTYDVENRPGFAA 621 T + R Sbjct: 244 MLTINPAKRITAHE 257 >2JC6-A nrPDB Length = 334 Score = 242 bits (617), Expect = 4e-64, Method: Composition-based stats. Identities = 63/258 (24%), Positives = 99/258 (38%), Gaps = 15/258 (5%) Query: 366 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 425 D K + + LG+G F V + K K AVK + +A + E V++ Sbjct: 19 DIKKIFEFKETLGTGAFSEVVLA--EEKATGKLFAVKCIPKKALKGKESS-IENEIAVLR 75 Query: 426 QLDNPYIVRMIGICEAESW-MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKY 484 ++ + IV + I E+ + LVM++ G L + + +K+ L+ QV + Y Sbjct: 76 KIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYY 135 Query: 485 LEESNFVHRDLAARNVLL---VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 541 L VHRDL N+L + ISDFGLSK + A + AP Sbjct: 136 LHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTA----CGTPGYVAP 191 Query: 542 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGER---MGCPAGCP 598 E + +S D WS GV+ + G P+ S++ + K E Sbjct: 192 EVLAQKPYSKAVDCWSIGVIAYILLC-GYPPFYDENDSKLFEQILKAEYEFDSPYWDDIS 250 Query: 599 REMYDLMNLCWTYDVENR 616 D + D R Sbjct: 251 DSAKDFIRNLMEKDPNKR 268 >1FOT-A nrPDB Length = 318 Score = 242 bits (617), Expect = 5e-64, Method: Composition-based stats. Identities = 56/244 (22%), Positives = 111/244 (45%), Gaps = 12/244 (4%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEAN-DPALKDELLAEANVMQQLDNPYIV 433 + LG+G+FG V + + + A+K+LK E + E ++ + +P+I+ Sbjct: 12 RTLGTGSFGRVHL--IRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFII 69 Query: 434 RMIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 RM G + + ++M+ E G L L++++ + +V + ++YL + ++ Sbjct: 70 RMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIY 129 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSK 552 RDL N+LL + KI+DFG +K + + APE ++ ++ Sbjct: 130 RDLKPENILLDKNGHIKITDFGFAKYVPD------VTYTLCGTPDYIAPEVVSTKPYNKS 183 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYD 612 D WSFG+L++E + G P+ + + E + P ++ DL++ T D Sbjct: 184 IDWWSFGILIYEMLA-GYTPFYDSNTMKTYEKILNAE-LRFPPFFNEDVKDLLSRLITRD 241 Query: 613 VENR 616 + R Sbjct: 242 LSQR 245 >4LG4-A nrPDB Length = 299 Score = 241 bits (616), Expect = 5e-64, Method: Composition-based stats. Identities = 65/255 (25%), Positives = 122/255 (47%), Gaps = 14/255 (5%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 ++LG G++G+V K + K+ + VA+K + E++ E++ E ++MQQ D+PY+V+ Sbjct: 17 EKLGEGSYGSVFKAIH--KESGQVVAIKQVPVESD----LQEIIKEISIMQQCDSPYVVK 70 Query: 435 MIG-ICEAESWMLVMEMAELGPLNKYLQ-QNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 G + +VME G ++ ++ +N+ + + I ++ G++YL +H Sbjct: 71 YYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIH 130 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSK 552 R++ A N+LL T+ +AK++DFG++ L + K T P W APE I ++ Sbjct: 131 RNIKAGNILLNTEGHAKLADFGVAGQLT--DTMAKRNTVIGTPF-WMAPEVIQEIGYNCV 187 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGC--PAGCPREMYDLMNLCWT 610 +D+WS G+ E + G+ PY + M+ P + D + C Sbjct: 188 ADIWSLGITSIEM-AEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLV 246 Query: 611 YDVENRPGFAAVELR 625 + E R + Sbjct: 247 KNPEQRATATQLLQH 261 >2XIK-A nrPDB Length = 294 Score = 241 bits (615), Expect = 7e-64, Method: Composition-based stats. Identities = 69/267 (25%), Positives = 116/267 (43%), Gaps = 9/267 (3%) Query: 360 PKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLA 419 + +D + L + +G G+FG V KG K + VA+KI+ E + ++D Sbjct: 10 NQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTK--EVVAIKIIDLEEAEDEIEDI-QQ 66 Query: 420 EANVMQQLDNPYIVRMIG-ICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQV 478 E V+ Q D+PYI R G ++ ++ME G L + +++ I ++ ++ Sbjct: 67 EITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLL-KPGPLEETYIATILREI 125 Query: 479 SMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKW 538 G+ YL +HRD+ A NVLL Q K++DFG++ L + K T P W Sbjct: 126 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLT--DTQIKRNTFVGTPF-W 182 Query: 539 YAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCP 598 APE I + K+D+WS G+ E + G+ P + V ++ K Sbjct: 183 MAPEVIKQSAYDFKADIWSLGITAIE-LAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHS 241 Query: 599 REMYDLMNLCWTYDVENRPGFAAVELR 625 + + + C D RP + Sbjct: 242 KPFKEFVEACLNKDPRFRPTAKELLKH 268 >3OMV-A nrPDB Length = 307 Score = 241 bits (615), Expect = 8e-64, Method: Composition-based stats. Identities = 78/293 (26%), Positives = 130/293 (44%), Gaps = 22/293 (7%) Query: 356 EEIRPKEVYLDRKLLTLEDKE------LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEAN 409 +IRP+ +E E +GSG+FGTV KG + VAVKILK Sbjct: 17 NKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGD-----VAVKILKVVDP 71 Query: 410 DPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQ-QNRHVKD 468 P E V+++ + I+ +G ++ +V + E L K+L Q + Sbjct: 72 TPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQM 131 Query: 469 KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKA 528 +I++ Q + GM YL N +HRD+ + N+ L KI DFGL+ +++ + + Sbjct: 132 FQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLA-TVKSRWSGSQQ 190 Query: 529 QTHGKWPVKWYAPECIN---YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKG-SEVTAM 584 V W APE I FS +SDV+S+G++++E + G+ PY + ++ M Sbjct: 191 VEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFM 249 Query: 585 LEKGERMG----CPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDV 633 + +G CP+ M L+ C E RP F + + + + Sbjct: 250 VGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSL 302 >4YZB-A nrPDB Length = 491 Score = 241 bits (614), Expect = 9e-64, Method: Composition-based stats. Identities = 65/259 (25%), Positives = 111/259 (42%), Gaps = 16/259 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNPYIV 433 + LG G+FG V + K + AVK++ K + K+ LL E ++++LD+P I+ Sbjct: 36 RVLGKGSFGEVILC--KDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHPNIM 93 Query: 434 RMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 ++ E + + LV E+ G L + + + + ++ QV G+ Y+ ++ VH Sbjct: 94 KLYEFFEDKGYFYLVTEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVH 153 Query: 493 RDLAARNVLLVT---QHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 RDL N+LL +I DFGLS + K + APE ++ + Sbjct: 154 RDLKPENLLLENKRKDANIRIIDFGLSTHFES----TKKMKDKIGTAYYIAPEVLHGT-Y 208 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGER---MGCPAGCPREMYDLMN 606 K DVWS GV+++ S G P+ G ++ +EKG+ + DL+ Sbjct: 209 DEKCDVWSTGVILYILLS-GCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIR 267 Query: 607 LCWTYDVENRPGFAAVELR 625 Y R Sbjct: 268 KMLAYVPTMRISARDALEH 286 >2WQN-A nrPDB Length = 310 Score = 241 bits (614), Expect = 9e-64, Method: Composition-based stats. Identities = 64/294 (21%), Positives = 133/294 (45%), Gaps = 17/294 (5%) Query: 339 EALPMDTEVYESPYADPEE-IRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVK 397 + + P P++ +RP Y +E K++G G F V + + V Sbjct: 2 DEQSQGMQGPPVPQFQPQKALRPDMGYNTLANFRIE-KKIGRGQFSEVYRAACLLDGV-- 58 Query: 398 TVAVKILKN-EANDPALKDELLAEANVMQQLDNPYIVRMI-GICEAESWMLVMEMAELGP 455 VA+K ++ + D + + + E ++++QL++P +++ E +V+E+A+ G Sbjct: 59 PVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGD 118 Query: 456 LNKYLQ----QNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKIS 511 L++ ++ Q R + ++ + + Q+ ++++ +HRD+ NV + K+ Sbjct: 119 LSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLG 178 Query: 512 DFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQK 571 D GL + + + + +PE I+ ++ KSD+WS G L++E + Q Sbjct: 179 DLGLGRFFSSKTTAAHSLV---GTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAAL-QS 234 Query: 572 PYRG--MKGSEVTAMLEKGERMGCPAG-CPREMYDLMNLCWTYDVENRPGFAAV 622 P+ G M + +E+ + P+ E+ L+N+C D E RP V Sbjct: 235 PFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYV 288 >4D2V-A nrPDB Length = 356 Score = 240 bits (613), Expect = 1e-63, Method: Composition-based stats. Identities = 53/252 (21%), Positives = 104/252 (41%), Gaps = 9/252 (3%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 + +G+G F VK + + + VA+KI+ L + E ++ L + +I Sbjct: 34 HETIGTGGFAKVKLACHIL--TGEMVAIKIMDKNTLGSDLP-RIKTEIEALKNLRHQHIC 90 Query: 434 RMIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 ++ + E +V+E G L Y+ + ++ + Q+ + Y+ + H Sbjct: 91 QLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAH 150 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF-SS 551 RDL N+L H K+ DFGL + +++Y+ + + APE I + S Sbjct: 151 RDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQ--ACCGALAYAAPELIQGKSYLGS 208 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 611 ++DVWS G+L++ G P+ + + A + +G+ P L+ Sbjct: 209 EADVWSMGILLYVLMC-GFLPFDDDTAAALVAKIMRGK-YDVPKWLSPSSILLLQQMLQV 266 Query: 612 DVENRPGFAAVE 623 D + R + Sbjct: 267 DPKKRISMKNLL 278 >4FZF-B nrPDB Length = 283 Score = 240 bits (613), Expect = 1e-63, Method: Composition-based stats. Identities = 66/261 (25%), Positives = 112/261 (42%), Gaps = 9/261 (3%) Query: 366 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 425 D + L + + +G G+FG V KG + + VA+KI+ E + ++D E V+ Sbjct: 5 DPEELFTKLERIGKGSFGEVFKGIDN--RTQQVVAIKIIDLEEAEDEIEDI-QQEITVLS 61 Query: 426 QLDNPYIVRMIG-ICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKY 484 Q D+ Y+ + G + ++ME G L+ + I ++ ++ G+ Y Sbjct: 62 QCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDY 120 Query: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 L +HRD+ A NVLL Q K++ FG++ L + K T P W APE I Sbjct: 121 LHSEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLT--DTQIKRNTFVGTPF-WMAPEVI 177 Query: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDL 604 + SK+D+WS G+ E + G+ P M V ++ K + + Sbjct: 178 QQSAYDSKADIWSLGITAIE-LAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEF 236 Query: 605 MNLCWTYDVENRPGFAAVELR 625 ++ C D RP + Sbjct: 237 IDACLNKDPSFRPTAKELLKH 257 >6AO5-A nrPDB Length = 362 Score = 240 bits (613), Expect = 1e-63, Method: Composition-based stats. Identities = 65/255 (25%), Positives = 122/255 (47%), Gaps = 14/255 (5%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 ++LG G++G+V K + K+ + VA+K + E++ E++ E ++MQQ D+PY+V+ Sbjct: 16 EKLGEGSYGSVFKAIH--KESGQVVAIKQVPVESD----LQEIIKEISIMQQCDSPYVVK 69 Query: 435 MIG-ICEAESWMLVMEMAELGPLNKYLQ-QNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 G + +VME G ++ ++ +N+ + + I ++ G++YL +H Sbjct: 70 YYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIH 129 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSK 552 R++ A N+LL T+ +AK++DFG++ L + K T P W APE I ++ Sbjct: 130 RNIKAGNILLNTEGHAKLADFGVAGQLT--DTMAKRNTVIGTPF-WMAPEVIQEIGYNCV 186 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGC--PAGCPREMYDLMNLCWT 610 +D+WS G+ E + G+ PY + M+ P + D + C Sbjct: 187 ADIWSLGITSIEM-AEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLV 245 Query: 611 YDVENRPGFAAVELR 625 + E R + Sbjct: 246 KNPEQRATATQLLQH 260 >3DB8-A nrPDB Length = 317 Score = 240 bits (612), Expect = 2e-63, Method: Composition-based stats. Identities = 66/290 (22%), Positives = 120/290 (41%), Gaps = 17/290 (5%) Query: 349 ESPYADPEEIRPKE---VYLDRKLLT--LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKI 403 S + DP+ KE V +D + + + + LG G F + K + A K+ Sbjct: 17 PSAHVDPKSAPLKEIPDVLVDPRTMKRYMRGRFLGKGGFAKCYEITDMDTK--EVFAGKV 74 Query: 404 L-KNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESW-MLVMEMAELGPLNKYLQ 461 + K+ P K+++ E + + LDNP++V G E + + +V+E+ L + + Sbjct: 75 VPKSMLLKPHQKEKMSTEIAIHKSLDNPHVVGFHGFFEDDDFVYVVLEICRRRSLLELHK 134 Query: 462 QNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRA 521 + + V + + Q G++YL + +HRDL N+ L KI DFGL+ + Sbjct: 135 RRKAVTEPEARYFMRQTIQGVQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEF 194 Query: 522 DENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 D + + APE + S + D+WS G +++ G+ P+ E Sbjct: 195 DGE---RKKDLCGTPNYIAPEVLCKKGHSFEVDIWSLGCILYTLL-VGKPPFETSCLKET 250 Query: 582 TAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYY 631 ++K E P L+ D RP A + L + ++ Sbjct: 251 YIRIKKNE-YSVPRHINPVASALIRRMLHADPTLRPSVAEL---LTDEFF 296 >3DAK-A nrPDB Length = 290 Score = 240 bits (612), Expect = 2e-63, Method: Composition-based stats. Identities = 70/289 (24%), Positives = 125/289 (43%), Gaps = 29/289 (10%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424 ++R L+ + +GSG V+ Y KK + VA+K + E ++ DELL E M Sbjct: 7 INRDDYELQ-EVIGSGATAVVQAAYCAPKK--EKVAIKRINLEKCQTSM-DELLKEIQAM 62 Query: 425 QQLDNPYIVRMI-GICEAESWMLVMEMAELGPLNKYL--------QQNRHVKDKNIIELV 475 Q +P IV + LVM++ G + + ++ + + I ++ Sbjct: 63 SQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATIL 122 Query: 476 HQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGK-- 533 +V G++YL ++ +HRD+ A N+LL +I+DFG+S L + + + Sbjct: 123 REVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFV 182 Query: 534 WPVKWYAPECINY-YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMG 592 W APE + + K+D+WSFG+ E + G PY +V + + + Sbjct: 183 GTPCWMAPEVMEQVRGYDFKADIWSFGITAIE-LATGAAPYHKYPPMKVLMLTLQNDPPS 241 Query: 593 CPAGCP---------REMYDLMNLCWTYDVENRPGFAAVELRLRNYYYD 632 G + +++LC D E RP A + LR+ ++ Sbjct: 242 LETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAEL---LRHKFFQ 287 >4FG9-A nrPDB Length = 320 Score = 239 bits (611), Expect = 2e-63, Method: Composition-based stats. Identities = 68/274 (24%), Positives = 108/274 (39%), Gaps = 16/274 (5%) Query: 352 YADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDP 411 E R K+ R + D LG+G F V K+ K VA+K + EA + Sbjct: 2 LGAVEGPRWKQAEDIRDIYDFRD-VLGTGAFSEVILAED--KRTQKLVAIKCIAKEALE- 57 Query: 412 ALKDELLAEANVMQQLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQNRHVKDKN 470 + + E V+ ++ +P IV + I E+ L+M++ G L + + +++ Sbjct: 58 GKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERD 117 Query: 471 IIELVHQVSMGMKYLEESNFVHRDLAARNVL---LVTQHYAKISDFGLSKALRADENYYK 527 L+ QV +KYL + VHRDL N+L L ISDFGLSK E+ Sbjct: 118 ASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKM----EDPGS 173 Query: 528 AQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 + + APE + +S D WS GV+ + G P+ +++ + K Sbjct: 174 VLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLC-GYPPFYDENDAKLFEQILK 232 Query: 588 GER---MGCPAGCPREMYDLMNLCWTYDVENRPG 618 E D + D E R Sbjct: 233 AEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFT 266 >3MV5-A nrPDB Length = 342 Score = 239 bits (610), Expect = 3e-63, Method: Composition-based stats. Identities = 63/265 (23%), Positives = 106/265 (40%), Gaps = 12/265 (4%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEAN-DPALKDELLAEANVMQQLDNPYIV 433 K LG G FG V + K + A+KILK E L E V+Q +P++ Sbjct: 16 KLLGKGTFGKVIL--VKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLT 73 Query: 434 RM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE-SNFV 491 + + VME A G L +L + R + ++ + YL N V Sbjct: 74 ALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVV 133 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 +RDL N++L + KI+DFGL K D K ++ APE + + Sbjct: 134 YRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKT---FCGTPEYLAPEVLEDNDYGR 190 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 611 D W GV+M+E G+ P+ ++ ++ E + P E L++ Sbjct: 191 AVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILM-EEIRFPRTLGPEAKSLLSGLLKK 248 Query: 612 DVENRP--GFAAVELRLRNYYYDVV 634 D + R G + +++ ++ + Sbjct: 249 DPKQRLGGGSEDAKEIMQHRFFAGI 273 >5HIE-A nrPDB Length = 302 Score = 239 bits (610), Expect = 3e-63, Method: Composition-based stats. Identities = 68/263 (25%), Positives = 116/263 (44%), Gaps = 21/263 (7%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 + +GSG+FGTV KG + VAVK+L P E V+++ + I+ Sbjct: 41 GQRIGSGSFGTVYKGKWHGD-----VAVKML-----TPQQLQAFKNEVGVLRKTRHVNIL 90 Query: 434 RMIGICEAESWMLVMEMAELGPLNKYLQQ-NRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 +G +V + E L +L + +I++ Q + GM YL + +H Sbjct: 91 LFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIH 150 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN---YYKF 549 RDL + N+ L KI DFGL+ +++ + + W APE I + Sbjct: 151 RDLKSNNIFLHEDLTVKIGDFGLA-TVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPY 209 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPYRGMKG-SEVTAMLEKGERMG----CPAGCPREMYDL 604 S +SDV++FG++++E + GQ PY + ++ M+ +G + CP+ M L Sbjct: 210 SFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRL 268 Query: 605 MNLCWTYDVENRPGFAAVELRLR 627 M C + RP F + + Sbjct: 269 MAECLKKKRDERPLFPQILASIE 291 >4RA4-A nrPDB Length = 355 Score = 239 bits (610), Expect = 3e-63, Method: Composition-based stats. Identities = 69/266 (25%), Positives = 118/266 (44%), Gaps = 12/266 (4%) Query: 356 EEIRPKEVYLDRKLLTLEDK--ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEA-NDPA 412 E+ + LDR LT + LG G+FG V K + A+KILK + Sbjct: 5 EDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLA--DRKGTEELYAIKILKKDVVIQDD 62 Query: 413 LKDELLAEANVMQQLDNP-YIVRMIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKN 470 + + E V+ LD P ++ ++ + + VME G L ++QQ K+ Sbjct: 63 DVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQ 122 Query: 471 IIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQT 530 + ++S+G+ +L + ++RDL NV+L ++ + KI+DFG+ K D +T Sbjct: 123 AVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDG--VTTRT 180 Query: 531 HGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGER 590 P + APE I Y + D W++GVL++E + GQ P+ G E+ + + Sbjct: 181 FCGTP-DYIAPEIIAYQPYGKSVDWWAYGVLLYEMLA-GQPPFDGEDEDELFQSIME-HN 237 Query: 591 MGCPAGCPREMYDLMNLCWTYDVENR 616 + P +E + T R Sbjct: 238 VSYPKSLSKEAVSICKGLMTKHPAKR 263 >4WNO-A nrPDB Length = 287 Score = 239 bits (609), Expect = 4e-63, Method: Composition-based stats. Identities = 68/283 (24%), Positives = 121/283 (42%), Gaps = 28/283 (9%) Query: 362 EVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEA 421 + RK L +G G F V KG ++ ++ VAVK + + + L E Sbjct: 17 KFEFSRKDL------IGHGAFAVVFKGRHRAAHDLE-VAVKCINKKNLAKSQT-LLGKEI 68 Query: 422 NVMQQLDNPYIVRMIGICE-AESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM 480 ++++L + IV + E A S LVME G L YL R + + I + Q++ Sbjct: 69 KILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAG 128 Query: 481 GMKYLEESNFVHRDLAARNVLLVTQH---------YAKISDFGLSKALRADENYYKAQTH 531 M+ L +HRDL +N+LL KI+DFG ++ L+++ A T Sbjct: 129 AMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSN---MMAATL 185 Query: 532 GKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE-- 589 P+ + APE I + K+D+WS G ++++ + G+ P++ ++ EK + Sbjct: 186 CGSPM-YMAPEVIMSQHYDGKADLWSIGTIVYQCLT-GKAPFQASSPQDLRLFYEKNKTL 243 Query: 590 RMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYD 632 P + L+ + ++R F + + D Sbjct: 244 VPTIPRETSAPLRQLLLALLQRNHKDRMDFDEF---FHHPFLD 283 >3SOA-A nrPDB Length = 444 Score = 238 bits (608), Expect = 4e-63, Method: Composition-based stats. Identities = 51/254 (20%), Positives = 102/254 (40%), Gaps = 13/254 (5%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +ELG G F V++ + + A I+ + +L EA + + L +P IVR Sbjct: 17 EELGKGAFSVVRRCVKVL--AGQEYAAMIINTKKLSARDHQKLEREARICRLLKHPNIVR 74 Query: 435 MIG-ICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + I E L+ ++ G L + + + + + + Q+ + + + VHR Sbjct: 75 LHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHR 134 Query: 494 DLAARNVLLVTQHY---AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 +L N+LL ++ K++DFGL+ + ++ + + +PE + + Sbjct: 135 NLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWF---GFAGTPGYLSPEVLRKDPYG 191 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG-ERMGCP--AGCPREMYDLMNL 607 D+W+ GV+++ G P+ + ++ G P E DL+N Sbjct: 192 KPVDLWACGVILYILL-VGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 250 Query: 608 CWTYDVENRPGFAA 621 T + R A Sbjct: 251 MLTINPSKRITAAE 264 >2JAM-A nrPDB Length = 304 Score = 238 bits (607), Expect = 5e-63, Method: Composition-based stats. Identities = 64/250 (25%), Positives = 102/250 (40%), Gaps = 19/250 (7%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLA-EANVMQQLDNPYIV 433 + LGSG F V + + K A+K +K PA +D L E V++++ + IV Sbjct: 15 EVLGSGAFSEVFL--VKQRLTGKLFALKCIKK---SPAFRDSSLENEIAVLKKIKHENIV 69 Query: 434 RMIGICE-AESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 + I E + LVM++ G L + + +K+ ++ QV +KYL E+ VH Sbjct: 70 TLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVH 129 Query: 493 RDLAARNVLL---VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 RDL N+L I+DFGLSK + T G + APE + + Sbjct: 130 RDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPG-----YVAPEVLAQKPY 184 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE---RMGCPAGCPREMYDLMN 606 S D WS GV+ + G P+ S++ +++G D + Sbjct: 185 SKAVDCWSIGVITYILLC-GYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFIC 243 Query: 607 LCWTYDVENR 616 D R Sbjct: 244 HLLEKDPNER 253 >4B6L-A nrPDB Length = 281 Score = 238 bits (607), Expect = 6e-63, Method: Composition-based stats. Identities = 56/262 (21%), Positives = 108/262 (41%), Gaps = 12/262 (4%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNP 430 L+ + LG G F + + AVK++ ++ P ++++L E + + L + Sbjct: 12 LKGRLLGKGGFARCYEATD--TETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHR 69 Query: 431 YIVRM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 +IVR +A++ + +E+ L + + + + + Q+ G+KYL + Sbjct: 70 HIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRG 129 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 +HRDL N + K+ DFGL+ L E + +T P + APE + Sbjct: 130 ILHRDLKLGNFFITENMELKVGDFGLAARLEPPE--QRKKTICGTP-NYVAPEVLLRQGH 186 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCW 609 ++DVWS G +M+ G P+ E +++ PA L+ Sbjct: 187 GPEADVWSLGCVMYTLLC-GSPPFETADLKETYRCIKQVH-YTLPASLSLPARQLLAAIL 244 Query: 610 TYDVENRPGFAAVELRLRNYYY 631 +RP + LR+ ++ Sbjct: 245 RASPRDRPSIDQI---LRHDFF 263 >4NEU-A nrPDB Length = 333 Score = 237 bits (604), Expect = 1e-62, Method: Composition-based stats. Identities = 79/278 (28%), Positives = 131/278 (47%), Gaps = 21/278 (7%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPY 431 LE EL SG FG V +++ + ++ +K + N + LL EA +M +L + Sbjct: 27 LESAELDSGGFGKVSLCFHRTQGLMI---MKTVYKGPNCIEHNEALLEEAKMMNRLRHSR 83 Query: 432 IVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 +V+++G+ E LVME E G L L+ ++ ++ GM YL Sbjct: 84 VVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGV 143 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLS-----KALRADENYYKAQTHG-----KWPVKWYA 540 +H+DL N+L+ + KI+D GL+ L +E+ + G + + A Sbjct: 144 IHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMA 203 Query: 541 PECINY--YKFSSKSDVWSFGVLMWEAFSYGQKPYR-GMKGSEVTAMLEKGERM---GCP 594 PE +N K + KSDV+SF V++W F+ ++PY + ++ ++ G R Sbjct: 204 PEHLNDVNAKPTEKSDVYSFAVVLWAIFAN-KEPYENAICEQQLIMCIKSGNRPDVDDIT 262 Query: 595 AGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYD 632 CPRE+ LM LCW + E RP F +E + R +Y Sbjct: 263 EYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLS 300 >4C0T-A nrPDB Length = 974 Score = 237 bits (604), Expect = 1e-62, Method: Composition-based stats. Identities = 73/392 (18%), Positives = 153/392 (39%), Gaps = 25/392 (6%) Query: 262 IGTQGNVNFGGRPQLPGSHPA--TWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQ---ES 316 G HP T S+ ++ + S +P + + +S Sbjct: 150 KSAPGTPLSSHSFDFRPHHPRAVTNSSLNVLLDTPNVSSEFNHLVDQTPPNESVERFDDS 209 Query: 317 TVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLED-- 374 + + E E D+ P+ E L + E +E A + I+ + + + D Sbjct: 210 NNTVDNTEEEENNDDTDEIPKSETLKQNEENWEKKGAAVKTIKTMDGEMKTIRRNVTDFK 269 Query: 375 --KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLA-EANVMQQLDNP- 430 KELG G++ TV ++ K AVK+L K + + E + + +L N Sbjct: 270 FGKELGEGSYSTVILATDKI--TGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNRL 327 Query: 431 YIVRMIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 ++ + + +S V++ A G L +++ + ++ Q+ +KY+ ++ Sbjct: 328 GVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEECTRHFGAQILDAIKYMHDNG 387 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQ------THGKWPVKWYAPEC 543 +HRDL N+LL + +I+DFG ++ L + + ++ +PE Sbjct: 388 VIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVSPEL 447 Query: 544 INYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYD 603 + DVW+FG ++++ + G+ P++ + K + AG P + D Sbjct: 448 LENKYCGKPGDVWAFGCIIYQMIA-GKPPFKATNEYLTFQKITK-LQFAFSAGFPTIIRD 505 Query: 604 LMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 L+ R ++ ++Y++ V+ Sbjct: 506 LIKKILVLQPSRRATIPEIQ---KHYFFQSVD 534 >4I6B-A nrPDB Length = 308 Score = 237 bits (604), Expect = 1e-62, Method: Composition-based stats. Identities = 55/261 (21%), Positives = 112/261 (42%), Gaps = 12/261 (4%) Query: 373 EDKELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNPY 431 K LG G F + K A KI+ + + P ++++ E + + L + + Sbjct: 32 RGKTLGKGGFAKCYEMTDLTNN--KVYAAKIIPHSRVSKPHQREKIDKEIELHRILHHKH 89 Query: 432 IVRMIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 +V+ E E+ +++E + L+ + + + + + Q+ G+KYL E Sbjct: 90 VVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEI 149 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 +HRDL N + K+ DFGL+ L E ++ +T P + +PE +N Sbjct: 150 LHRDLKLGNFFINESMELKVGDFGLAARLEPLE--HRRRTICGTP-NYLSPEVLNKQGHG 206 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWT 610 ++SD+W+ G +M+ G+ P+ E + + R P+ L+ + Sbjct: 207 AESDIWALGCVMYTML-LGRPPFETTNLKETYRSIREA-RYTMPSSLLAPAKHLIASMLS 264 Query: 611 YDVENRPGFAAVELRLRNYYY 631 + E+RP + +R+ ++ Sbjct: 265 KNPEDRPSLDDI---IRHDFF 282 >6QAU-A nrPDB Length = 280 Score = 235 bits (600), Expect = 4e-62, Method: Composition-based stats. Identities = 61/257 (23%), Positives = 112/257 (43%), Gaps = 19/257 (7%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G G F V +G ++ K VA+K + + + L E ++++L + IV + Sbjct: 19 VGHGAFAVVFRGRHRQK-TDWEVAIKSINKKNLSKSQI-LLGKEIKILKELQHENIVALY 76 Query: 437 GICE-AESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDL 495 + E S LVME G L YLQ + + I +HQ++ M+ L +HRDL Sbjct: 77 DVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDL 136 Query: 496 AARNVLLV---------TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY 546 +N+LL + KI+DFG ++ L ++ + APE I Sbjct: 137 KPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSN----MMAADLCGSPMYMAPEVIMS 192 Query: 547 YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERM--GCPAGCPREMYDL 604 + +K+D+WS G ++++ G+ P++ ++ EK + P + +L Sbjct: 193 QHYDAKADLWSIGTVIYQCL-VGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANL 251 Query: 605 MNLCWTYDVENRPGFAA 621 + + ++R F A Sbjct: 252 LLGLLQRNQKDRMDFEA 268 >4APC-A nrPDB Length = 350 Score = 235 bits (600), Expect = 5e-62, Method: Composition-based stats. Identities = 44/272 (16%), Positives = 115/272 (42%), Gaps = 9/272 (3%) Query: 357 EIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE 416 ++ + +Y + +++G G+FG + + + +K + ++E Sbjct: 12 DLGTENLYFQSMEKYVRLQKIGEGSFGK--AILVKSTEDGRQYVIKEINISRMSSKEREE 69 Query: 417 LLAEANVMQQLDNPYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRH--VKDKNIIE 473 E V+ + +P IV+ E +VM+ E G L K + + ++ I++ Sbjct: 70 SRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILD 129 Query: 474 LVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGK 533 Q+ + +K++ + +HRD+ ++N+ L ++ DFG+++ L + +A Sbjct: 130 WFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARA---CI 186 Query: 534 WPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGC 593 + +PE +++KSD+W+ G +++E + + + + + G Sbjct: 187 GTPYYLSPEICENKPYNNKSDIWALGCVLYELCTL-KHAFEAGSMKNLVLKIISGSFPPV 245 Query: 594 PAGCPREMYDLMNLCWTYDVENRPGFAAVELR 625 ++ L++ + + +RP ++ + Sbjct: 246 SLHYSYDLRSLVSQLFKRNPRDRPSVNSILEK 277 >5DBX-A nrPDB Length = 328 Score = 234 bits (598), Expect = 6e-62, Method: Composition-based stats. Identities = 65/270 (24%), Positives = 113/270 (41%), Gaps = 25/270 (9%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 + +GSG V+ + ++ + VA+K + E ++ DELL E M Q +P +V Sbjct: 17 EVIGSGATAVVQAALCKPRQ--ERVAIKRINLEKCQTSM-DELLKEIQAMSQCSHPNVVT 73 Query: 435 MI-GICEAESWMLVMEMAELGPLNKYL--------QQNRHVKDKNIIELVHQVSMGMKYL 485 + LVM++ G + + +N +++ I ++ +V G+ YL Sbjct: 74 YYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYL 133 Query: 486 EESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYY--KAQTHGKWPVKWYAPEC 543 + +HRDL A N+LL +I+DFG+S L + K + W APE Sbjct: 134 HRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPCWMAPEV 193 Query: 544 INY-YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCP---- 598 + + K+D+WSFG+ E + G PY +V + + + G Sbjct: 194 MEQVRGYDFKADMWSFGITAIE-LATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEM 252 Query: 599 -----REMYDLMNLCWTYDVENRPGFAAVE 623 + L++LC D RP A + Sbjct: 253 MKKYGKSFRKLLSLCLQKDPSKRPTAAELL 282 >5DYK-A nrPDB Length = 853 Score = 234 bits (598), Expect = 7e-62, Method: Composition-based stats. Identities = 66/328 (20%), Positives = 134/328 (40%), Gaps = 27/328 (8%) Query: 317 TVSFNPYEPELAPWAADKGPQREAL--PMDTEVYESPYADPEEIRPKEVYLDRKLLTLED 374 T S + W DK + + PM + E ++ E+ +R Sbjct: 493 TASVISKVNNVECWFVDKSVFLQIIQGPMLAHLEERIKMQDTKVEMDELETER------- 545 Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEAN-DPALKDELLAEANVMQQLDNPYIV 433 +G G FGTVK +++ K+ A+K + + + ++ + E + + D+P+I+ Sbjct: 546 -IIGRGTFGTVKLVHHKPTKI--RYALKCVSKRSIINLNQQNNIKLEREITAENDHPFII 602 Query: 434 RMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 R++ +++ + + E+ G L +++ + + + + ++YL E N V+ Sbjct: 603 RLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEYLHERNIVY 662 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSK 552 RDL N+LL Q Y K+ DFG +K ++ +A T P + APE I + Sbjct: 663 RDLKPENILLDKQGYVKLIDFGCAKKVQG-----RAYTLVGTP-HYMAPEVILGKGYGCT 716 Query: 553 SDVWSFGVLMWEAFSYGQKPY--RGMKGSEVTAMLEKGERMGCPAGCPR-EMYDLMNLCW 609 D+W+ G+ ++E G P+ E+ + G ++ P + +LM Sbjct: 717 VDIWALGICLYEFIC-GPLPFGNDEEDQLEIFRDILTG-QLTFPDYVTDTDSINLMKRLL 774 Query: 610 TYDVENRP--GFAAVELRLRNYYYDVVN 635 + R + + ++ N Sbjct: 775 CRLPQGRIGCSINGFKDIKDHPFFSNFN 802 >5F9E-A nrPDB Length = 353 Score = 234 bits (598), Expect = 7e-62, Method: Composition-based stats. Identities = 69/269 (25%), Positives = 113/269 (42%), Gaps = 14/269 (5%) Query: 360 PKEVYLDRKLLTLED----KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKD 415 KE + L +ED K LG G+FG V + KK + A+K LK + Sbjct: 6 NKERPSLQIKLKIEDFELHKMLGKGSFGKVFLAEF--KKTNQFFAIKALKKDVVLMDDDV 63 Query: 416 E-LLAEANVMQQL-DNPYIVRMIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKNII 472 E + E V+ ++P++ M + E+ VME G L ++Q Sbjct: 64 ECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRAT 123 Query: 473 ELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHG 532 ++ +G+++L V+RDL N+LL + KI+DFG+ K + Sbjct: 124 FYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGD---AKTNEF 180 Query: 533 KWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMG 592 + APE + K++ D WSFGVL++E GQ P+ G E+ + + + Sbjct: 181 CGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEML-IGQSPFHGQDEEELFHSI-RMDNPF 238 Query: 593 CPAGCPREMYDLMNLCWTYDVENRPGFAA 621 P +E DL+ + + E R G Sbjct: 239 YPRWLEKEAKDLLVKLFVREPEKRLGVRG 267 >4UZD-A nrPDB Length = 287 Score = 234 bits (598), Expect = 7e-62, Method: Composition-based stats. Identities = 61/254 (24%), Positives = 106/254 (41%), Gaps = 11/254 (4%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNPYI 432 + LG G FG V + K +A+K+L K + ++ +L E + L +P I Sbjct: 13 GRPLGKGKFGNVYLAREKQSKF--ILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNI 70 Query: 433 VRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFV 491 +R+ G + L++E A LG + + LQ+ ++ + +++ + Y + Sbjct: 71 LRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVI 130 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 HRD+ N+LL + KI+DFG S + +T + + PE I Sbjct: 131 HRDIKPENLLLGSAGELKIADFGWSVHAPSS-----RRTTLCGTLDYLPPEMIEGRMHDE 185 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 611 K D+WS GVL +E F G+ P+ E + + E P DL++ + Sbjct: 186 KVDLWSLGVLCYE-FLVGKPPFEANTYQETYKRISRVE-FTFPDFVTEGARDLISRLLKH 243 Query: 612 DVENRPGFAAVELR 625 + RP V Sbjct: 244 NPSQRPMLREVLEH 257 >3D2K-A nrPDB Length = 272 Score = 234 bits (598), Expect = 7e-62, Method: Composition-based stats. Identities = 65/265 (24%), Positives = 111/265 (41%), Gaps = 15/265 (5%) Query: 367 RKLLTLED----KELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEA 421 ++ TLED + LG G FG V + K +A+K+L K + ++ +L E Sbjct: 6 KRQWTLEDFDIGRPLGKGKFGNVYLARERQSKF--ILALKVLFKTQLEKAGVEHQLRREV 63 Query: 422 NVMQQLDNPYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM 480 + L +P I+R+ G + L++E A LG + + LQ+ ++ + +++ Sbjct: 64 EIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELAN 123 Query: 481 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540 + Y +HRD+ N+LL + KI+DFG S + +T + + Sbjct: 124 ALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSS-----RRTTLCGTLDYLP 178 Query: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600 PE I K D+WS GVL +E F G P+ E + + E P Sbjct: 179 PEMIEGRMHDEKVDLWSLGVLCYE-FLVGMPPFEAHTYQETYRRISRVE-FTFPDFVTEG 236 Query: 601 MYDLMNLCWTYDVENRPGFAAVELR 625 DL++ ++ R A V Sbjct: 237 ARDLISRLLKHNASQRLTLAEVLEH 261 >4PDS-A nrPDB Length = 347 Score = 234 bits (597), Expect = 8e-62, Method: Composition-based stats. Identities = 72/274 (26%), Positives = 119/274 (43%), Gaps = 27/274 (9%) Query: 367 RKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQ 426 K ++ D+ +G G F TVKK + KT +VKI+ D + E V+Q+ Sbjct: 29 FKDFSIIDEVVGQGAFATVKKAI--ERTTGKTFSVKIISKRKV-IGNMDGVTRELEVLQK 85 Query: 427 LDNPYIVRMIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYL 485 L++P IVR+ G E ES+ +VME G L ++ + V + E+ Q+ +KY+ Sbjct: 86 LNHPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYI 145 Query: 486 EESNFVHRDLAARNVLLVTQH--YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPEC 543 HRDL N+L+ KI+ FGL+K ++ + ++ K + + APE Sbjct: 146 HSMGISHRDLKPDNILIEQDDPVLVKITAFGLAK-VQGNGSFMKT---FCGTLAYVAPEV 201 Query: 544 INYY-------------KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGER 590 I ++SS D+WS G L++ + G P+ G ++ + +G Sbjct: 202 IRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILT-GHLPFSGSTQDQLYKQIGRGSY 260 Query: 591 MGCPA---GCPREMYDLMNLCWTYDVENRPGFAA 621 P E D ++ D NR A Sbjct: 261 HEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAK 294 >4XBR-A nrPDB Length = 366 Score = 234 bits (597), Expect = 9e-62, Method: Composition-based stats. Identities = 60/295 (20%), Positives = 112/295 (37%), Gaps = 18/295 (6%) Query: 334 KGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMK 393 + PQRE + E + + + YLD + ++G G+ G V ++ Sbjct: 65 RSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI------KIGEGSTGIV--CIATVR 116 Query: 394 KVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICE-AESWMLVMEMAE 452 K VAVK + + ++ L E +M+ + +V M + +VME E Sbjct: 117 SSGKLVAVKKM--DLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLE 174 Query: 453 LGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISD 512 G L + + + ++ I + V + L +HRD+ + ++LL K+SD Sbjct: 175 GGALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSD 233 Query: 513 FGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKP 572 FG + + K+ W APE I+ + + D+WS G+++ E G+ P Sbjct: 234 FGFCAQVSKEVPRRKSLV---GTPYWMAPELISRLPYGPEVDIWSLGIMVIEMV-DGEPP 289 Query: 573 YRGMKGSEVTAMLEKGE--RMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELR 625 Y + M+ R+ + ++ D R A + Sbjct: 290 YFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKH 344 >3TXO-A nrPDB Length = 353 Score = 234 bits (596), Expect = 1e-61, Method: Composition-based stats. Identities = 54/267 (20%), Positives = 110/267 (41%), Gaps = 13/267 (4%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNE-ANDPALKDELLAEANVMQQL-DNPYI 432 + LG G+FG V ++K+ AVK+LK + + + E ++ ++P++ Sbjct: 29 RVLGKGSFGKVMLA--RVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFL 86 Query: 433 VRMIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFV 491 ++ + + VME G L ++Q++R + ++ + +L + + Sbjct: 87 TQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGII 146 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 +RDL NVLL + + K++DFG+ K N T P + APE + + Sbjct: 147 YRDLKLDNVLLDHEGHCKLADFGMCK--EGICNGVTTATFCGTP-DYIAPEILQEMLYGP 203 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 611 D W+ GVL++E G P+ ++ + E + P + ++ T Sbjct: 204 AVDWWAMGVLLYEMLC-GHAPFEAENEDDLFEAILNDEVV-YPTWLHEDATGILKSFMTK 261 Query: 612 DVENR---PGFAAVELRLRNYYYDVVN 635 + R LR+ ++ ++ Sbjct: 262 NPTMRLGSLTQGGEHAILRHPFFKEID 288 >2OU7-A nrPDB Length = 335 Score = 234 bits (596), Expect = 1e-61, Method: Composition-based stats. Identities = 57/257 (22%), Positives = 105/257 (40%), Gaps = 12/257 (4%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNPYIVRM 435 LG G F + K + A KI+ K+ P ++++ E ++ + L + ++V Sbjct: 49 LGKGGFAKCFEISDADTK--EVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGF 106 Query: 436 IGICEAESWMLV-MEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRD 494 G E ++ V +E+ L + ++ + + + + Q+ +G +YL + +HRD Sbjct: 107 HGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRD 166 Query: 495 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSD 554 L N+ L KI DFGL+ + D K + APE ++ S + D Sbjct: 167 LKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLC---GTPNYIAPEVLSKKGHSFEVD 223 Query: 555 VWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVE 614 VWS G +M+ G+ P+ E ++K E P L+ D Sbjct: 224 VWSIGCIMYTLL-VGKPPFETSCLKETYLRIKKNE-YSIPKHINPVAASLIQKMLQTDPT 281 Query: 615 NRPGFAAVELRLRNYYY 631 RP + L + ++ Sbjct: 282 ARPT---INELLNDEFF 295 >4J52-A nrPDB Length = 293 Score = 234 bits (596), Expect = 1e-61, Method: Composition-based stats. Identities = 57/257 (22%), Positives = 105/257 (40%), Gaps = 12/257 (4%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNPYIVRM 435 LG G F + K + A KI+ K+ P ++++ E ++ + L + ++V Sbjct: 22 LGKGGFAKCFEISDADTK--EVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGF 79 Query: 436 IGICEAESWMLV-MEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRD 494 G E ++ V +E+ L + ++ + + + + Q+ +G +YL + +HRD Sbjct: 80 HGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRD 139 Query: 495 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSD 554 L N+ L KI DFGL+ + D K + APE ++ S + D Sbjct: 140 LKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLC---GTPNYIAPEVLSKKGHSFEVD 196 Query: 555 VWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVE 614 VWS G +M+ G+ P+ E ++K E P L+ D Sbjct: 197 VWSIGCIMYTLL-VGKPPFETSCLKETYLRIKKNE-YSIPKHINPVAASLIQKMLQTDPT 254 Query: 615 NRPGFAAVELRLRNYYY 631 RP + L + ++ Sbjct: 255 ARPT---INELLNDEFF 268 >3IS5-A nrPDB Length = 285 Score = 233 bits (594), Expect = 2e-61, Method: Composition-based stats. Identities = 69/267 (25%), Positives = 120/267 (44%), Gaps = 21/267 (7%) Query: 368 KLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL 427 L + ++LGSG FG V + + + +K + + +++ AE V++ L Sbjct: 21 DDLFIFKRKLGSGAFGDVHLVEERSSGLERV--IKTINKD-RSQVPMEQIEAEIEVLKSL 77 Query: 428 DNPYIVRMIGICEA-ESWMLVMEMAELGPLNKYLQ----QNRHVKDKNIIELVHQVSMGM 482 D+P I+++ + E + +VME E G L + + + + + + + EL+ Q+ + Sbjct: 78 DHPNIIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNAL 137 Query: 483 KYLEESNFVHRDLAARNVLLVT---QHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY 539 Y + VH+DL N+L KI DFGL++ ++DE+ T+ + Sbjct: 138 AYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEH----STNAAGTALYM 193 Query: 540 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAML---EKGERMGCPAG 596 APE + K D+WS GV+M+ + G P+ G EV E + C Sbjct: 194 APEVFK-RDVTFKCDIWSAGVVMYFLLT-GCLPFTGTSLEEVQQKATYKEPNYAVECRPL 251 Query: 597 CPREMYDLMNLCWTYDVENRPGFAAVE 623 P+ + DL+ T D E RP A V Sbjct: 252 TPQAV-DLLKQMLTKDPERRPSAAQVL 277 >2Q0N-A nrPDB Length = 301 Score = 233 bits (594), Expect = 2e-61, Method: Composition-based stats. Identities = 60/294 (20%), Positives = 111/294 (37%), Gaps = 18/294 (6%) Query: 335 GPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKK 394 PQRE + E + + + YLD + ++G G+ G V ++ Sbjct: 1 SPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFI------KIGEGSTGIV--CIATVRS 52 Query: 395 VVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICE-AESWMLVMEMAEL 453 K VAVK + + ++ L E +M+ + +V M + +VME E Sbjct: 53 SGKLVAVKKM--DLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEG 110 Query: 454 GPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDF 513 G L + + + ++ I + V + L +HRD+ + ++LL K+SDF Sbjct: 111 GALTD-IVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDF 169 Query: 514 GLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPY 573 G + + K+ W APE I+ + + D+WS G+++ E G+ PY Sbjct: 170 GFCAQVSKEVPRRKSLV---GTPYWMAPELISRLPYGPEVDIWSLGIMVIEMV-DGEPPY 225 Query: 574 RGMKGSEVTAMLEKGE--RMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELR 625 + M+ R+ + ++ D R A + Sbjct: 226 FNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKH 279 >2XNP-A nrPDB Length = 279 Score = 232 bits (592), Expect = 3e-61, Method: Composition-based stats. Identities = 59/262 (22%), Positives = 120/262 (45%), Gaps = 18/262 (6%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 +G+G++G +K + K K + K L + A K L++E N++++L +P IVR Sbjct: 13 TIGTGSYGRCQK--IRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRY 70 Query: 436 IGICEAES---WMLVMEMAELGPLNKYL----QQNRHVKDKNIIELVHQVSMGMKYLEES 488 + +VME E G L + ++ +++ ++ ++ ++ Q+++ +K Sbjct: 71 YDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRR 130 Query: 489 N-----FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPEC 543 + +HRDL NV L + K+ DFGL++ L D ++ K + +PE Sbjct: 131 SDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFV---GTPYYMSPEQ 187 Query: 544 INYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYD 603 +N ++ KSD+WS G L++E + P+ E+ + +G+ P E+ + Sbjct: 188 MNRMSYNEKSDIWSLGCLLYELCAL-MPPFTAFSQKELAGKIREGKFRRIPYRYSDELNE 246 Query: 604 LMNLCWTYDVENRPGFAAVELR 625 ++ +RP + Sbjct: 247 IITRMLNLKDYHRPSVEEILEN 268 >2YCR-A nrPDB Length = 323 Score = 232 bits (592), Expect = 3e-61, Method: Composition-based stats. Identities = 71/273 (26%), Positives = 120/273 (43%), Gaps = 26/273 (9%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE------LLAEANVMQ 425 + K LGSG G VK + +K K VA+KI+ E + E +++ Sbjct: 13 IMSKTLGSGACGEVKLAF--ERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILK 70 Query: 426 QLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYL 485 +L++P I+++ +AE + +V+E+ E G L + N+ +K+ +Q+ + ++YL Sbjct: 71 KLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYL 130 Query: 486 EESNFVHRDLAARNVLLV---TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 542 E+ +HRDL NVLL KI+DFG SK L +T P + APE Sbjct: 131 HENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKIL---GETSLMRTLCGTPT-YLAPE 186 Query: 543 CI---NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGS-EVTAMLEKGERMGCP---A 595 + ++ D WS GV+++ S G P+ + + + G+ P A Sbjct: 187 VLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 245 Query: 596 GCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 + DL+ D + R E LR+ Sbjct: 246 EVSEKALDLVKKLLVVDPKARFT---TEEALRH 275 >4NIF-A nrPDB Length = 333 Score = 231 bits (590), Expect = 6e-61, Method: Composition-based stats. Identities = 54/262 (20%), Positives = 104/262 (39%), Gaps = 22/262 (8%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 + +G G++ K+ + K AVK++ DP+ + E+L ++ +P I+ Sbjct: 14 ETIGVGSYSECKRCVH--KATNMEYAVKVIDKSKRDPSEEIEIL-----LRYGQHPNIIT 66 Query: 435 MIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + + + + LV E+ G L + + + ++ ++H + ++YL VHR Sbjct: 67 LKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 126 Query: 494 DLAARNVLLVTQ----HYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 DL N+L V + +I DFG +K LRA+ + + APE + + Sbjct: 127 DLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPC---YTANFVAPEVLKRQGY 183 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPY---RGMKGSEVTAMLEKGERMGCPAGC---PREMYD 603 D+WS G+L++ + G P+ E+ + G+ D Sbjct: 184 DEGCDIWSLGILLYTMLA-GYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKD 242 Query: 604 LMNLCWTYDVENRPGFAAVELR 625 L++ D R V Sbjct: 243 LVSKMLHVDPHQRLTAKQVLQH 264 >2J90-A nrPDB Length = 304 Score = 231 bits (590), Expect = 6e-61, Method: Composition-based stats. Identities = 58/264 (21%), Positives = 112/264 (42%), Gaps = 19/264 (7%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALK----DELLAEANVMQQLDN 429 +ELGSG F V+K + K K A K +K + + +E+ E N+++++ + Sbjct: 31 GEELGSGQFAIVRKC--RQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRH 88 Query: 430 PYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 P I+ + I E ++ +L++E+ G L +L + + + + + Q+ G+ YL Sbjct: 89 PNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHSK 148 Query: 489 NFVHRDLAARNVLLVTQH----YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 H DL N++L+ ++ K+ DFG++ + A + + ++ APE + Sbjct: 149 RIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEF----KNIFGTPEFVAPEIV 204 Query: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGER---MGCPAGCPREM 601 NY ++D+WS GV+ + S G P+ G E + + Sbjct: 205 NYEPLGLEADMWSIGVITYILLS-GASPFLGETKQETLTNISAVNYDFDEEYFSNTSELA 263 Query: 602 YDLMNLCWTYDVENRPGFAAVELR 625 D + D + R A Sbjct: 264 KDFIRRLLVKDPKRRMTIAQSLEH 287 >4BBM-A nrPDB Length = 331 Score = 231 bits (590), Expect = 6e-61, Method: Composition-based stats. Identities = 61/289 (21%), Positives = 114/289 (39%), Gaps = 41/289 (14%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G G++G V K + K + VA+K +D +K + E +++QL + +V ++ Sbjct: 33 VGEGSYGMVMKC--RNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLL 90 Query: 437 GICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDL 495 +C+ + W LV E + L+ + + + + + Q+ G+ + N +HRD+ Sbjct: 91 EVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDI 150 Query: 496 AARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY-KFSSKSD 554 N+L+ K+ DFG ++ L A Y + +W + APE + K+ D Sbjct: 151 KPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRW---YRAPELLVGDVKYGKAVD 207 Query: 555 VWSFGVLMWEAFSYGQKPYRGMKGSEVTAML---------------------------EK 587 VW+ G L+ E F G+ + G + + E Sbjct: 208 VWAIGCLVTEMF-MGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEI 266 Query: 588 GERMGCPAGCP---REMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDV 633 ER P + DL C D + RP L + ++ + Sbjct: 267 KEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPF---CAELLHHDFFQM 312 >4JXF-A nrPDB Length = 266 Score = 231 bits (589), Expect = 7e-61, Method: Composition-based stats. Identities = 59/252 (23%), Positives = 104/252 (41%), Gaps = 10/252 (3%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEAN-DPALKDELLAEANVMQQLDNPYIVRM 435 LG G+F V + + VA+K++ +A + + E + QL +P I+ + Sbjct: 15 LGKGSFAGVYRA--ESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILEL 72 Query: 436 IGICEAESW-MLVMEMAELGPLNKYLQQN-RHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 E ++ LV+EM G +N+YL+ + + +HQ+ GM YL +HR Sbjct: 73 YNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHR 132 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKS 553 DL N+LL KI+DFGL+ L+ + + +PE +S Sbjct: 133 DLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLC---GTPNYISPEIATRSAHGLES 189 Query: 554 DVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDV 613 DVWS G + + G+ P+ + + P+ E DL++ + Sbjct: 190 DVWSLGCMFYTLL-IGRPPFDTDTVKNTLNKVVLAD-YEMPSFLSIEAKDLIHQLLRRNP 247 Query: 614 ENRPGFAAVELR 625 +R ++V Sbjct: 248 ADRLSLSSVLDH 259 >6HXF-B nrPDB Length = 302 Score = 231 bits (589), Expect = 7e-61, Method: Composition-based stats. Identities = 59/259 (22%), Positives = 112/259 (43%), Gaps = 17/259 (6%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 ELG G FG V K + K+ A K++ E ++ + E ++ D+PYIV++ Sbjct: 26 ELGDGAFGKVYKA--KNKETGALAAAKVI--ETKSEEELEDYIVEIEILATCDHPYIVKL 81 Query: 436 IGICEAESWMLVM-EMAELGPLNKY-LQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 +G + + +M E G ++ L+ +R + + I + Q+ + +L +HR Sbjct: 82 LGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHR 141 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN-----YYK 548 DL A NVL+ + +++DFG+S + + + W APE + Sbjct: 142 DLKAGNVLMTLEGDIRLADFGVSAK---NLKTLQKRDSFIGTPYWMAPEVVMCETMKDTP 198 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGC--PAGCPREMYDLMN 606 + K+D+WS G+ + E + + P+ + V + K + P+ E D + Sbjct: 199 YDYKADIWSLGITLIEM-AQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLK 257 Query: 607 LCWTYDVENRPGFAAVELR 625 + + E RP A + Sbjct: 258 IALDKNPETRPSAAQLLEH 276 >4YFF-A nrPDB Length = 311 Score = 231 bits (589), Expect = 7e-61, Method: Composition-based stats. Identities = 69/282 (24%), Positives = 134/282 (47%), Gaps = 16/282 (5%) Query: 360 PKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILK-NEANDPALKDELL 418 P +L + + +GSG+FG V KG + K VA+K + N + D Sbjct: 34 PSHFHLQLSEIEF-HEIIGSGSFGKVYKGRCRNK----IVAIKRYRANTYCSKSDVDMFC 88 Query: 419 AEANVMQQLDNPYIVRMIGICEAES--WMLVMEMAELGPLNKYLQQNRH-VKDKNIIELV 475 E +++ QL++P +++ +G C + + +V + G L L + + + ++ + + Sbjct: 89 REVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIA 148 Query: 476 HQVSMGMKYLEE--SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGK 533 V+ GM+YL +HRDL + N+LL +A ++DFG S+ L++ + T Sbjct: 149 VDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDED--NMTKQP 206 Query: 534 WPVKWYAPECI-NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE-RM 591 ++W APE +++ K+DV+S+ + +WE + G+ P+ +K + A + R Sbjct: 207 GNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILT-GEIPFAHLKPAAAAADMAYHHIRP 265 Query: 592 GCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDV 633 P+ + L+ W E RP F+ V ++L ++ Sbjct: 266 PIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNI 307 >3NIZ-A nrPDB Length = 311 Score = 231 bits (588), Expect = 9e-61, Method: Composition-based stats. Identities = 62/279 (22%), Positives = 119/279 (42%), Gaps = 40/279 (14%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +++G G +G V K + VA+K ++ +A D + + E +++++L +P IV Sbjct: 27 EKVGEGTYGVVYKAKDSQ---GRIVALKRIRLDAEDEGIPSTAIREISLLKELHHPNIVS 83 Query: 435 MIGICEAE-SWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFVH 492 +I + +E LV E E L K L +N+ ++D I ++Q+ G+ + + +H Sbjct: 84 LIDVIHSERCLTLVFEFMEK-DLKKVLDENKTGLQDSQIKIYLYQLLRGVAHCHQHRILH 142 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY-YKFSS 551 RDL +N+L+ + K++DFGL++A Y TH + + AP+ + K+S+ Sbjct: 143 RDLKPQNLLINSDGALKLADFGLARAFGIPVRSY---THEVVTLWYRAPDVLMGSKKYST 199 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCP------------- 598 D+WS G + E + G+ + G+ + + P P Sbjct: 200 SVDIWSIGCIFAEMIT-GKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWKQRTF 258 Query: 599 ----------------REMYDLMNLCWTYDVENRPGFAA 621 +E DL++ +D R Sbjct: 259 QVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARD 297 >3I6U-A nrPDB Length = 419 Score = 231 bits (588), Expect = 1e-60, Method: Composition-based stats. Identities = 73/292 (25%), Positives = 127/292 (43%), Gaps = 30/292 (10%) Query: 353 ADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPA 412 D + + PK + + + K LGSG G VK + +K K VA++I+ Sbjct: 123 VDDQSVYPKALRDEY----IMSKTLGSGACGEVKLAF--ERKTCKKVAIRIISKRKFAIG 176 Query: 413 LKDE------LLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHV 466 E + E ++++L++P I+++ +AE + +V+E+ E G L + N+ + Sbjct: 177 SAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRL 236 Query: 467 KDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV---TQHYAKISDFGLSKALRADE 523 K+ +Q+ + ++YL E+ +HRDL NVLL KI+DFG SK L Sbjct: 237 KEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKIL---G 293 Query: 524 NYYKAQTHGKWPVKWYAPECI---NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGS- 579 +T P + APE + ++ D WS GV+++ S G P+ + Sbjct: 294 ETSLMRTLCGTPT-YLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEHRTQV 351 Query: 580 EVTAMLEKGERMGCP---AGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 + + G+ P A + DL+ D + R E LR+ Sbjct: 352 SLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFT---TEEALRH 400 >4JG6-A nrPDB Length = 355 Score = 230 bits (587), Expect = 1e-60, Method: Composition-based stats. Identities = 57/262 (21%), Positives = 109/262 (41%), Gaps = 22/262 (8%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +++G G++ K+ + K AVKI+ DP + E+L ++ +P I+ Sbjct: 41 EDIGVGSYSVCKRCIH--KATNMEFAVKIIDKSKRDPTEEIEIL-----LRYGQHPNIIT 93 Query: 435 MIGICEAESW-MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + + + + +V E+ + G L + + + ++ ++ ++ ++YL VHR Sbjct: 94 LKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHR 153 Query: 494 DLAARNVLLVTQ----HYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 DL N+L V + +I DFG +K LRA+ + + APE + + Sbjct: 154 DLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPC---YTANFVAPEVLERQGY 210 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPY---RGMKGSEVTAMLEKGERM---GCPAGCPREMYD 603 + D+WS GVL++ + G P+ E+ A + G+ G D Sbjct: 211 DAACDIWSLGVLLYTMLT-GYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKD 269 Query: 604 LMNLCWTYDVENRPGFAAVELR 625 L++ D R A V Sbjct: 270 LVSKMLHVDPHQRLTAALVLRH 291 >2UV2-A nrPDB Length = 325 Score = 230 bits (587), Expect = 1e-60, Method: Composition-based stats. Identities = 60/260 (23%), Positives = 111/260 (42%), Gaps = 19/260 (7%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 ELG G FG V K Q K+ A K++ ++ + ++ + E +++ D+P IV++ Sbjct: 44 ELGDGAFGKVYKA--QNKETSVLAAAKVIDTKSEEEL--EDYMVEIDILASCDHPNIVKL 99 Query: 436 IGIC--EAESWMLVMEMAELGPLNKY-LQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 + E W+L+ E G ++ L+ R + + I + Q + YL ++ +H Sbjct: 100 LDAFYYENNLWILI-EFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIH 158 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN-----YY 547 RDL A N+L K++DFG+S + + + W APE + Sbjct: 159 RDLKAGNILFTLDGDIKLADFGVSAK---NTRTIQRRDSFIGTPYWMAPEVVMCETSKDR 215 Query: 548 KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGC--PAGCPREMYDLM 605 + K+DVWS G+ + E + + P+ + V + K E P+ D + Sbjct: 216 PYDYKADVWSLGITLIEM-AEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFL 274 Query: 606 NLCWTYDVENRPGFAAVELR 625 C +V+ R + + Sbjct: 275 KKCLEKNVDARWTTSQLLQH 294 >6FD3-A nrPDB Length = 300 Score = 229 bits (585), Expect = 2e-60, Method: Composition-based stats. Identities = 55/263 (20%), Positives = 99/263 (37%), Gaps = 12/263 (4%) Query: 366 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 425 D K +++G G GTV + VA+K + K+ ++ E VM+ Sbjct: 19 DPKKKYTRFEKIGQGASGTVYTALDIA--TGQEVAIKQMN--LQQQPKKELIINEILVMR 74 Query: 426 QLDNPYIVRMIGICE-AESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKY 484 + NP IV + + +VME G L + + + + I + + + + Sbjct: 75 ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDF 133 Query: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 L + +HRD+ + N+LL K++DFG + +++ W APE + Sbjct: 134 LHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMV---GTPYWMAPEVV 190 Query: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGC--PAGCPREMY 602 + K D+WS G++ E G+ PY ++ P Sbjct: 191 TRKAYGPKVDIWSLGIMAIEMV-EGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFR 249 Query: 603 DLMNLCWTYDVENRPGFAAVELR 625 D +N C DV+ R + Sbjct: 250 DFLNRCLEMDVDRRGSAKELLQH 272 >4AW2-A nrPDB Length = 437 Score = 229 bits (585), Expect = 2e-60, Method: Composition-based stats. Identities = 65/310 (20%), Positives = 126/310 (40%), Gaps = 20/310 (6%) Query: 339 EALPMDTEVYE-SPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVK 397 L + + E +A P + K++ L R+ + K +G G FG V ++K K Sbjct: 44 SPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEIL-KVIGRGAFGEV--AVVKLKNADK 100 Query: 398 TVAVKIL-KNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAES-WMLVMEMAELGP 455 A+KIL K E A E +V+ D+ +I + + ++ LVM+ G Sbjct: 101 VFAMKILNKWEMLKRAETACFREERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGD 160 Query: 456 LNKYLQQ-NRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFG 514 L L + + ++ + ++ + + + + ++VHRD+ N+L+ + +++DFG Sbjct: 161 LLTLLSKFEDRLPEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFG 220 Query: 515 LSKALRADENYYKAQTHGKWPVKWYAPECIN-----YYKFSSKSDVWSFGVLMWEAFSYG 569 L D + + +PE + ++ + D WS GV M+E YG Sbjct: 221 SCLKLMEDGTVQSS--VAVGTPDYISPEILQAMEGGKGRYGPECDWWSLGVCMYEML-YG 277 Query: 570 QKPYRGMKGSEVTAMLEK-GERMGCP---AGCPREMYDLMNLCWTYDVENRPGFAAVELR 625 + P+ E + ER P DL+ E+R G +E Sbjct: 278 ETPFYAESLVETYGKIMNHKERFQFPTQVTDVSENAKDLIRRLICSR-EHRLGQNGIEDF 336 Query: 626 LRNYYYDVVN 635 ++ ++ ++ Sbjct: 337 KKHPFFSGID 346 >6BXI-A nrPDB Length = 333 Score = 229 bits (584), Expect = 3e-60, Method: Composition-based stats. Identities = 63/298 (21%), Positives = 120/298 (40%), Gaps = 41/298 (13%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKN-EANDPALKDELLAEANVMQQLDNPYIV 433 K +G G FG V+ Q K A+KIL+ + + + AE +++ + D+ ++V Sbjct: 12 KVIGRGAFGEVRL--VQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVV 69 Query: 434 RMIGICEAE-SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 +M + + + L+ME G + L + + ++ + + + + + + F+H Sbjct: 70 KMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIH 129 Query: 493 RDLAARNVLLVTQHYAKISDFGLSK----------------------ALRADENYYKAQT 530 RD+ N+LL ++ + K+SDFGL + + KA+T Sbjct: 130 RDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAET 189 Query: 531 ----------HGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSE 580 + APE ++ D WS GV+M+E G P+ E Sbjct: 190 WKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEML-IGYPPFCSETPQE 248 Query: 581 VTAMLEK-GERMGCPAGCP--REMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 + E + P P + DL+ + + E+R G VE N +++ V+ Sbjct: 249 TYKKVMNWKETLTFPPEVPISEKAKDLILR-FCCEWEHRIGAPGVEEIKSNSFFEGVD 305 >3TKU-A nrPDB Length = 433 Score = 229 bits (584), Expect = 3e-60, Method: Composition-based stats. Identities = 79/338 (23%), Positives = 133/338 (39%), Gaps = 22/338 (6%) Query: 311 GNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYE-SPYADPEEIRPKEVYLDRKL 369 R ES +S L + AL D V E +A P KE+ L R+ Sbjct: 34 PWRNESALSVETLLDVLVCLYTECS--HSALRRDKYVAEFLEWAKPFTQLVKEMQLHRED 91 Query: 370 LTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLD 428 + K +G G FG V +MK + A+KIL K E A E +V+ D Sbjct: 92 FEII-KVIGRGAFGEV--AVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGD 148 Query: 429 NPYIVRMIGICEAESW-MLVMEMAELGPLNKYLQQ-NRHVKDKNIIELVHQVSMGMKYLE 486 +I + + E+ LVM+ G L L + + + + ++ + + + Sbjct: 149 CQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIH 208 Query: 487 ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY 546 + ++VHRD+ NVLL + +++DFG + D + + +PE + Sbjct: 209 QLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSS--VAVGTPDYISPEILQA 266 Query: 547 Y-----KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK-GERMGCPA---GC 597 K+ + D WS GV M+E YG+ P+ E + ER P+ Sbjct: 267 MEDGMGKYGPECDWWSLGVCMYEML-YGETPFYAESLVETYGKIMNHEERFQFPSHVTDV 325 Query: 598 PREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 E DL+ E R G +E ++ +++ +N Sbjct: 326 SEEAKDLIQRLICSR-ERRLGQNGIEDFKKHAFFEGLN 362 >2BPM-A nrPDB Length = 309 Score = 228 bits (582), Expect = 4e-60, Method: Composition-based stats. Identities = 61/293 (20%), Positives = 121/293 (41%), Gaps = 45/293 (15%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +++G G +G V K ++ + VA+K ++ + + + E +++++L++P IV+ Sbjct: 13 EKIGEGTYGVVYKARNKL--TGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVK 70 Query: 435 MIGICEAES-WMLVMEMAELGPLNKYLQQN--RHVKDKNIIELVHQVSMGMKYLEESNFV 491 ++ + E+ LV E L K++ + + I + Q+ G+ + + Sbjct: 71 LLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 129 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK-FS 550 HRDL +N+L+ T+ K++DFGL++A Y TH + + APE + K +S Sbjct: 130 HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY---THEVVTLWYRAPEILLGCKYYS 186 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP---------------A 595 + D+WS G + E + + + G SE+ + +G P Sbjct: 187 TAVDIWSLGCIFAEMVTR-RALFPG--DSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 243 Query: 596 GCPREMYD---------------LMNLCWTYDVENRPGFAAVELRLRNYYYDV 633 P+ L++ YD R A ++ DV Sbjct: 244 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKA--ALAHPFFQDV 294 >1VZO-A nrPDB Length = 355 Score = 228 bits (582), Expect = 5e-60, Method: Composition-based stats. Identities = 62/277 (22%), Positives = 117/277 (42%), Gaps = 23/277 (8%) Query: 375 KELGSGNFGTVKKGYY-QMKKVVKTVAVKILKNEA--NDPALKDELLAEANVMQQLD-NP 430 K LG+G +G V K A+K+LK + E V++ + +P Sbjct: 60 KVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSP 119 Query: 431 YIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 ++V + + E+ + L+++ G L +L Q + + V ++ + +++L + Sbjct: 120 FLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLG 179 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY-- 547 ++RD+ N+LL + + ++DFGLSK ADE + +++ AP+ + Sbjct: 180 IIYRDIKLENILLDSNGHVVLTDFGLSKEFVADET--ERAYDFCGTIEYMAPDIVRGGDS 237 Query: 548 KFSSKSDVWSFGVLMWEAFSYGQKPY--RGMKGS--EVTAMLEKGERMGCPAGCPREMYD 603 D WS GVLM+E + G P+ G K S E++ + K E P D Sbjct: 238 GHDKAVDWWSLGVLMYELLT-GASPFTVDGEKNSQAEISRRILKSE-PPYPQEMSALAKD 295 Query: 604 LMNLCWTYDVENRP-----GFAAVELRLRNYYYDVVN 635 L+ D + R ++ L ++ +N Sbjct: 296 LIQRLLMKDPKKRLGCGPRDADEIKEHL---FFQKIN 329 >2W4O-A nrPDB Length = 349 Score = 228 bits (582), Expect = 5e-60, Method: Composition-based stats. Identities = 61/259 (23%), Positives = 111/259 (42%), Gaps = 20/259 (7%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 + ELG G V + + K K A+K+LK + ++ E V+ +L +P I+ Sbjct: 58 ESELGRGATSIVYRC--KQKGTQKPYALKVLKKTVDKKIVR----TEIGVLLRLSHPNII 111 Query: 434 RMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 ++ I E + + LV+E+ G L + + + +++ + V Q+ + YL E+ VH Sbjct: 112 KLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVH 171 Query: 493 RDLAARNVLLVT---QHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 RDL N+L T KI+DFGLSK + + + APE + + Sbjct: 172 RDLKPENLLYATPAPDAPLKIADFGLSKIVE----HQVLMKTVCGTPGYCAPEILRGCAY 227 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREM----YDLM 605 + D+WS G++ + G +P+ +G + + E+ DL+ Sbjct: 228 GPEVDMWSVGIITYILLC-GFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLV 286 Query: 606 NLCWTYDVENRP-GFAAVE 623 D + R F A++ Sbjct: 287 RKLIVLDPKKRLTTFQALQ 305 >3PFQ-A nrPDB Length = 674 Score = 227 bits (580), Expect = 8e-60, Method: Composition-based stats. Identities = 77/332 (23%), Positives = 135/332 (40%), Gaps = 17/332 (5%) Query: 314 QESTVSFNPYEPELAPWAADKGPQ---REALPMDTEVYESPYADPEEIRPKEVYLDRKLL 370 QE FN P ++ Q R + T+ E A+ DR L Sbjct: 281 QEEGEYFNVPVPPEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKL 340 Query: 371 TLEDK--ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEA-NDPALKDELLAEANVMQQ- 426 T + LG G+FG V + K + AVKILK + + + E V+ Sbjct: 341 TDFNFLMVLGKGSFGKVML--SERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALP 398 Query: 427 LDNPYIVRMIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYL 485 P++ ++ + + VME G L ++QQ K+ + + ++++G+ +L Sbjct: 399 GKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 458 Query: 486 EESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 + ++RDL NV+L ++ + KI+DFG+ K D +T P + APE I Sbjct: 459 QSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG--VTTKTFCGTP-DYIAPEIIA 515 Query: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLM 605 Y + D W+FGVL++E + GQ P+ G E+ + + + P +E + Sbjct: 516 YQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME-HNVAYPKSMSKEAVAIC 573 Query: 606 NLCWTYDVENRPGF--AAVELRLRNYYYDVVN 635 T R G + ++ ++ Sbjct: 574 KGLMTKHPGKRLGCGPEGERDIKEHAFFRYID 605 >3Q53-A nrPDB Length = 306 Score = 227 bits (580), Expect = 9e-60, Method: Composition-based stats. Identities = 55/263 (20%), Positives = 100/263 (38%), Gaps = 12/263 (4%) Query: 366 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 425 D K +++G G GTV + VA++ + K+ ++ E VM+ Sbjct: 18 DPKKKYTRFEKIGQGASGTVYTAMDVA--TGQEVAIRQMN--LQQQPKKELIINEILVMR 73 Query: 426 QLDNPYIVRMIGICE-AESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKY 484 + NP IV + + +VME G L + + + + I + + +++ Sbjct: 74 ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALEF 132 Query: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 L + +HRD+ + N+LL K++DFG + +++ W APE + Sbjct: 133 LHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMV---GTPYWMAPEVV 189 Query: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGC--PAGCPREMY 602 + K D+WS G++ E G+ PY ++ P Sbjct: 190 TRKAYGPKVDIWSLGIMAIEMI-EGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFR 248 Query: 603 DLMNLCWTYDVENRPGFAAVELR 625 D +N C DVE R + Sbjct: 249 DFLNRCLEMDVEKRGSAKELIQH 271 >2X4F-A nrPDB Length = 373 Score = 227 bits (578), Expect = 1e-59, Method: Composition-based stats. Identities = 68/296 (22%), Positives = 129/296 (43%), Gaps = 19/296 (6%) Query: 334 KGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMK 393 K + AL +D +P+ D + K+ ++ + + LG G FG V K + Sbjct: 55 KSKRTSALAVDIPAPPAPF-DHRIVTAKQGAVNSFYTVSKTEILGGGRFGQVHKC--EET 111 Query: 394 KVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAES-WMLVMEMAE 452 +A KI+K K+E+ E +VM QLD+ ++++ E+++ +LVME + Sbjct: 112 ATGLKLAAKIIKTRGMK--DKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVD 169 Query: 453 LGPLNK-YLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQH--YAK 509 G L + ++ ++ + + I + Q+ G++++ + +H DL N+L V + K Sbjct: 170 GGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIK 229 Query: 510 ISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYG 569 I DFGL++ + E ++ APE +NY S +D+WS GV+ + S G Sbjct: 230 IIDFGLARRYKPREKL----KVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLS-G 284 Query: 570 QKPYRGMKGSEVTAMLEKGERMGCPA----GCPREMYDLMNLCWTYDVENRPGFAA 621 P+ G +E + R E + ++ + R + Sbjct: 285 LSPFLGDNDAETLNNILAC-RWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASE 339 >6BDL-A nrPDB Length = 347 Score = 226 bits (577), Expect = 2e-59, Method: Composition-based stats. Identities = 64/246 (26%), Positives = 108/246 (43%), Gaps = 9/246 (3%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEAN-DPALKDELLAEANVMQQLDNPYIVR 434 LG G FG V+ + ++ KT A+KILK D ++ + +E +MQ + +IVR Sbjct: 41 TLGVGGFGRVELVQLKSEE-SKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVR 99 Query: 435 MIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + +++ ++ME G L L+ +D V YL ++R Sbjct: 100 LYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYR 159 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKS 553 DL N++L + YAK+ DFG +K + + K T P ++ APE I + Sbjct: 160 DLKPENLILDHRGYAKLVDFGFAKKIGFGK---KTWTFCGTP-EYVAPEIILNKGHDISA 215 Query: 554 DVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERM-GCPAGCPREMYDLMNLCWTYD 612 D WS G+LM+E + G P+ G + ++ +G M P + +L+ + Sbjct: 216 DYWSLGILMYELLT-GSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDN 274 Query: 613 VENRPG 618 R G Sbjct: 275 PSERLG 280 >5JZN-A nrPDB Length = 280 Score = 226 bits (577), Expect = 2e-59, Method: Composition-based stats. Identities = 60/269 (22%), Positives = 116/269 (43%), Gaps = 22/269 (8%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 + +G GNF VK+ + + A+KI+K + + E ++++++ +P IV Sbjct: 24 GRTIGDGNFAVVKECV--ERSTAREYALKIIKKSKC-RGKEHMIQNEVSILRRVKHPNIV 80 Query: 434 RMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 +I + + LVME+ + G L + +++ +++ ++ +KYL N VH Sbjct: 81 LLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVH 140 Query: 493 RDLAARNVLL----VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 RD+ N+L+ K+ DFGL+ + T P + APE I Sbjct: 141 RDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGP-----LYTVCGTPT-YVAPEIIAETG 194 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSE--VTAMLEKGE---RMGCPAGCPREMYD 603 + K D+W+ GV+ + G P+RG + + + G+ + Sbjct: 195 YGLKVDIWAAGVITYILLC-GFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKE 253 Query: 604 LMNLCWTYDVENRPGFAAVELRLRNYYYD 632 L+ + DV+ R F+AV++ + D Sbjct: 254 LITMMLLVDVDQR--FSAVQVLEHPWVND 280 >2I0E-A nrPDB Length = 353 Score = 226 bits (576), Expect = 2e-59, Method: Composition-based stats. Identities = 66/279 (23%), Positives = 120/279 (43%), Gaps = 16/279 (5%) Query: 366 DRKLLTLEDK----ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEA-NDPALKDELLAE 420 +R + L D LG G+FG V + K + AVKILK + + + E Sbjct: 13 NRDRMKLTDFNFLMVLGKGSFGKVML--SERKGTDELYAVKILKKDVVIQDDDVECTMVE 70 Query: 421 ANVMQQ-LDNPYIVRMIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQV 478 V+ P++ ++ + + VME G L ++QQ K+ + + ++ Sbjct: 71 KRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI 130 Query: 479 SMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKW 538 ++G+ +L+ ++RDL NV+L ++ + KI+DFG+ K D +T P + Sbjct: 131 AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG--VTTKTFCGTP-DY 187 Query: 539 YAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCP 598 APE I Y + D W+FGVL++E + GQ P+ G E+ + + + P Sbjct: 188 IAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME-HNVAYPKSMS 245 Query: 599 REMYDLMNLCWTYDVENRPGF--AAVELRLRNYYYDVVN 635 +E + T R G + ++ ++ Sbjct: 246 KEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYID 284 >4AGU-A nrPDB Length = 311 Score = 226 bits (576), Expect = 2e-59, Method: Composition-based stats. Identities = 60/291 (20%), Positives = 119/291 (40%), Gaps = 41/291 (14%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 ++G G++G V K + + + VA+K +DP +K L E +++QL +P +V + Sbjct: 10 KIGEGSYGVVFKC--RNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNL 67 Query: 436 IGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRD 494 + + + + LV E + L++ + R V + + + Q + + + N +HRD Sbjct: 68 LEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRD 127 Query: 495 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI-NYYKFSSKS 553 + N+L+ K+ DFG ++ L +YY + +W + +PE + ++ Sbjct: 128 VKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRW---YRSPELLVGDTQYGPPV 184 Query: 554 DVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK--------------------GERMGC 593 DVW+ G + E S G + G + ++ K G ++ Sbjct: 185 DVWAIGCVFAELLS-GVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPD 243 Query: 594 PAGC-PREMY---------DLMNLCWTYDVENRPGFAAVELRLRNYYYDVV 634 P P E+ L+ C D R E L + Y++ + Sbjct: 244 PEDMEPLELKFPNISYPALGLLKGCLHMDPTERLT---CEQLLHHPYFENI 291 >6CMJ-A nrPDB Length = 321 Score = 226 bits (575), Expect = 3e-59, Method: Composition-based stats. Identities = 59/282 (20%), Positives = 127/282 (45%), Gaps = 28/282 (9%) Query: 361 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPAL------- 413 V LD+ L E +G G++G VK Y + A+K+L + Sbjct: 29 DCVQLDQYTLKDE---IGKGSYGVVKLAYNENDNT--YYAMKVLSKKKLIRQAGGCIQPR 83 Query: 414 --KDELLAEANVMQQLDNPYIVRMIGICEA---ESWMLVMEMAELGPLNKYLQQNRHVKD 468 +++ E ++++LD+P +V+++ + + + +V E+ GP+ + + + + + Sbjct: 84 GPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTLKPLSE 142 Query: 469 KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKA 528 + G++YL +HRD+ N+L+ + KI+DFG+S + + Sbjct: 143 DQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALL-- 200 Query: 529 QTHGKWPVKWYAPECINYYK--FSSKS-DVWSFGVLMWEAFSYGQKPYRGMKGSEVTAML 585 ++ + APE ++ + FS K+ DVW+ GV ++ F +GQ P+ + + + + Sbjct: 201 -SNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLY-CFVFGQCPFMDERIMCLHSKI 258 Query: 586 EKGERMGCP--AGCPREMYDLMNLCWTYDVENRPGFAAVELR 625 K + + P ++ DL+ + E+R ++L Sbjct: 259 -KSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLH 299 >2Y7J-A nrPDB Length = 365 Score = 226 bits (575), Expect = 3e-59, Method: Composition-based stats. Identities = 71/339 (20%), Positives = 137/339 (40%), Gaps = 28/339 (8%) Query: 312 NRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLT 371 R+ S + A A+ +A P TE PE+ P Sbjct: 36 QRRAFIRSLRDDPSQSANLLAEAKKLNDAQPKGTENLYFQSMGPEDELPDWAAAKEFYQK 95 Query: 372 LEDK-ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEAND------PALKDELLAEANVM 424 + K +G G V++ ++ AVKI++ A +++ E +++ Sbjct: 96 YDPKDVIGRGVSSVVRRCVHRA--TGHEFAVKIMEVTAERLSPEQLEEVREATRRETHIL 153 Query: 425 QQL-DNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGM 482 +Q+ +P+I+ +I E+ S+M LV ++ G L YL + + +K ++ + + Sbjct: 154 RQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAV 213 Query: 483 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 542 +L +N VHRDL N+LL ++SDFG S L E + + APE Sbjct: 214 SFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLREL----CGTPGYLAPE 269 Query: 543 CINYY------KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG-ERMGCP- 594 + + + D+W+ GV+++ + G P+ + + M+ +G + P Sbjct: 270 ILKCSMDETHPGYGKEVDLWACGVILFTLLA-GSPPFWHRRQILMLRMIMEGQYQFSSPE 328 Query: 595 -AGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYD 632 + DL++ D E R E L++ +++ Sbjct: 329 WDDRSSTVKDLISRLLQVDPEARLTA---EQALQHPFFE 364 >3GUB-A nrPDB Length = 295 Score = 225 bits (573), Expect = 6e-59, Method: Composition-based stats. Identities = 57/267 (21%), Positives = 115/267 (43%), Gaps = 22/267 (8%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALK----DELLAEANVMQQLDN 429 +ELGSG F VKK + K A K +K + + +++ E ++++++ + Sbjct: 16 GEELGSGQFAVVKKC--REKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQH 73 Query: 430 PYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 P ++ + + E ++ +L+ E+ G L +L + + ++ E + Q+ G+ YL Sbjct: 74 PNVITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSL 133 Query: 489 NFVHRDLAARNVLLVTQH----YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 H DL N++L+ ++ KI DFGL+ + + + ++ APE + Sbjct: 134 QIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEF----KNIFGTPEFVAPEIV 189 Query: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP---AGCPREM 601 NY ++D+WS GV+ + S G P+ G E A + + Sbjct: 190 NYEPLGLEADMWSIGVITYILLS-GASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALA 248 Query: 602 YDLMNLCWTYDVENRPGFAAVELRLRN 628 D + D + R ++ L++ Sbjct: 249 KDFIRRLLVKDPKKR---MTIQDSLQH 272 >6E9W-A nrPDB Length = 443 Score = 224 bits (572), Expect = 8e-59, Method: Composition-based stats. Identities = 60/266 (22%), Positives = 110/266 (41%), Gaps = 16/266 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKN-EANDPALKDELLAEANVMQQLDNPYIV 433 K +G G FG V+ + K K A+K+L E + E ++M ++P++V Sbjct: 108 KVIGRGAFGEVQLVRH--KSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVV 165 Query: 434 RMIGICEAESW-MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 ++ + + + +VME G L L N V +K +V + + + F+H Sbjct: 166 QLFYAFQDDRYLYMVMEYMPGGDLVN-LMSNYDVPEKWARFYTAEVVLALDAIHSMGFIH 224 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK---- 548 RD+ N+LL + K++DFG + + + T P + +PE + Sbjct: 225 RDVKPDNMLLDKSGHLKLADFGTCMKMNKEG-MVRCDTAVGTP-DYISPEVLKSQGGDGY 282 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGER-MGCPA--GCPREMYDLM 605 + + D WS GV ++E G P+ + + + + P +E +L+ Sbjct: 283 YGRECDWWSVGVFLYEML-VGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLI 341 Query: 606 NLCWTYDVENRPGFAAVELRLRNYYY 631 T D E R G VE R+ ++ Sbjct: 342 CAFLT-DREVRLGRNGVEEIKRHLFF 366 >1PHK-A nrPDB Length = 298 Score = 224 bits (571), Expect = 1e-58, Method: Composition-based stats. Identities = 63/276 (22%), Positives = 117/276 (42%), Gaps = 28/276 (10%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNE-------ANDPALKDELLAEANVMQQL 427 + LG G V++ + K K AVKI+ L++ L E ++++++ Sbjct: 23 EILGRGVSSVVRRCIH--KPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDILRKV 80 Query: 428 D-NPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYL 485 +P I+++ E ++ LV ++ + G L YL + + +K +++ + + L Sbjct: 81 SGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEVICAL 140 Query: 486 EESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI- 544 + N VHRDL N+LL K++DFG S L E + + APE I Sbjct: 141 HKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREV----CGTPSYLAPEIIE 196 Query: 545 -----NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG-ERMGCP--AG 596 N+ + + D+WS GV+M+ + G P+ K + M+ G + G P Sbjct: 197 CSMNDNHPGYGKEVDMWSTGVIMYTLLA-GSPPFWHRKQMLMLRMIMSGNYQFGSPEWDD 255 Query: 597 CPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYD 632 + DL++ + R E L + ++ Sbjct: 256 YSDTVKDLVSRFLVVQPQKRYTA---EEALAHPFFQ 288 >3F3Z-A nrPDB Length = 277 Score = 223 bits (569), Expect = 1e-58, Method: Composition-based stats. Identities = 54/265 (20%), Positives = 103/265 (38%), Gaps = 21/265 (7%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 + +G G++G VK + ++ + A K + + D E +M+ LD+P I+ Sbjct: 14 ENTIGRGSWGEVKIAVQKGTRIRR--AAKKIPKYFVE--DVDRFKQEIEIMKSLDHPNII 69 Query: 434 RMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 R+ E + LVME+ G L + + R ++ + ++ V + Y + N H Sbjct: 70 RLYETFEDNTDIYLVMELCTGGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLNVAH 129 Query: 493 RDLAARNVLL---VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 RDL N L K+ DFGL+ + + + +P+ + + Sbjct: 130 RDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTK----VGTPYYVSPQVLEGL-Y 184 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPA----GCPREMYDLM 605 + D WS GV+M+ G P+ SEV + +G P + L+ Sbjct: 185 GPECDEWSAGVMMYVLLC-GYPPFSAPTDSEVMLKIREGT-FTFPEKDWLNVSPQAESLI 242 Query: 606 NLCWTYDVENRPGFAAVELRLRNYY 630 T + R +++ ++ Sbjct: 243 RRLLTKSPKQRIT--SLQALEHEWF 265 >2YAB-A nrPDB Length = 361 Score = 223 bits (568), Expect = 2e-58, Method: Composition-based stats. Identities = 61/284 (21%), Positives = 119/284 (41%), Gaps = 25/284 (8%) Query: 357 EIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNE----ANDPA 412 E ++ D + +ELGSG F VKK + K A K +K + Sbjct: 3 ETFKQQKVEDFYDI---GEELGSGQFAIVKKC--REKSTGLEYAAKFIKKRQSRASRRGV 57 Query: 413 LKDELLAEANVMQQLDNPYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNI 471 ++E+ E ++++Q+ +P I+ + + E + +L++E+ G L +L Q + ++ Sbjct: 58 CREEIEREVSILRQVLHPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEA 117 Query: 472 IELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQH----YAKISDFGLSKALRADENYYK 527 + Q+ G+ YL H DL N++L+ ++ + K+ DFGL+ + + Sbjct: 118 TSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEF-- 175 Query: 528 AQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 + ++ APE +NY ++D+WS GV+ + S G P+ G E A + Sbjct: 176 --KNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLS-GASPFLGDTKQETLANITA 232 Query: 588 GER---MGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 + D + + R ++ LR+ Sbjct: 233 VSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLT---IQEALRH 273 >2F57-A nrPDB Length = 317 Score = 222 bits (567), Expect = 3e-58, Method: Composition-based stats. Identities = 54/290 (18%), Positives = 105/290 (36%), Gaps = 18/290 (6%) Query: 337 QREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVV 396 + + E + + YL + ++G G+ G V K Sbjct: 19 FQSMSRVSHEQFRAALQLVVSPGDPREYLANFI------KIGEGSTGIV--CIATEKHTG 70 Query: 397 KTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICE-AESWMLVMEMAELGP 455 K VAVK + + ++ L E +M+ + +V M + +VME E G Sbjct: 71 KQVAVKKM--DLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGA 128 Query: 456 LNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGL 515 L + + + ++ I + V + YL +HRD+ + ++LL + K+SDFG Sbjct: 129 LTD-IVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGF 187 Query: 516 SKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG 575 + + K+ W APE I+ + ++ D+WS G+++ E G+ PY Sbjct: 188 CAQVSKEVPKRKSLV---GTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMI-DGEPPYFN 243 Query: 576 MKGSEVTAMLEKGERMGCPA--GCPREMYDLMNLCWTYDVENRPGFAAVE 623 + + + ++L + R + Sbjct: 244 EPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELL 293 >3A8W-A nrPDB Length = 345 Score = 222 bits (567), Expect = 3e-58, Method: Composition-based stats. Identities = 59/278 (21%), Positives = 124/278 (44%), Gaps = 26/278 (9%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNE-ANDPALKDELLAEANVMQQL-DNPYI 432 + +G G++ V ++KK + A+K++K E ND D + E +V +Q ++P++ Sbjct: 15 RVIGRGSYAKVLL--VRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFL 72 Query: 433 VRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFV 491 V + + ES V+E G L ++Q+ R + +++ ++S+ + YL E + Sbjct: 73 VGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGII 132 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 +RDL NVLL ++ + K++D+G+ K + + + APE + + Sbjct: 133 YRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGD---TTSTFCGTPNYIAPEILRGEDYGF 189 Query: 552 KSDVWSFGVLMWEAFSYGQKPY--------RGMKGSEVTAMLEKGERMGCPAGCPREMYD 603 D W+ GVLM+E + G+ P+ + + +++ P + Sbjct: 190 SVDWWALGVLMFEMMA-GRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAAS 248 Query: 604 LMNLCWTYDVENRP------GFAAVELRLRNYYYDVVN 635 ++ D + R GFA ++ + ++ V+ Sbjct: 249 VLKSFLNKDPKERLGCHPQTGFADIQ---GHPFFRNVD 283 >1G3N-A nrPDB Length = 326 Score = 222 bits (565), Expect = 5e-58, Method: Composition-based stats. Identities = 64/300 (21%), Positives = 120/300 (40%), Gaps = 53/300 (17%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLD---NPYI 432 E+G G +G V K +K + VA+K ++ + + + + E V++ L+ +P + Sbjct: 18 EIGEGAYGKVFKARD-LKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNV 76 Query: 433 VRMIGICE------AESWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGMKY 484 VR+ +C LV E + L YL + V + I +++ Q+ G+ + Sbjct: 77 VRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDF 135 Query: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 L VHRDL +N+L+ + K++DFGL++ ++ A T + + APE + Sbjct: 136 LHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY----SFQMALTSVVVTLWYRAPEVL 191 Query: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREM--- 601 +++ D+WS G + E F + +RG + + + PR++ Sbjct: 192 LQSSYATPVDLWSVGCIFAEMFRR-KPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALP 250 Query: 602 -----------------------YDLMNLCWTYDVENR---------PGFAAVELRLRNY 629 DL+ C T++ R P F +E N Sbjct: 251 RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENL 310 >4FR4-A nrPDB Length = 384 Score = 221 bits (564), Expect = 5e-58, Method: Composition-based stats. Identities = 66/289 (22%), Positives = 122/289 (42%), Gaps = 21/289 (7%) Query: 355 PEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEAN-DPAL 413 P ++V D + + +G G+FG V Q K A+K + + + Sbjct: 4 PVFDENEDVNFDHFEIL---RAIGKGSFGKV--CIVQKNDTKKMYAMKYMNKQKCVERNE 58 Query: 414 KDELLAEANVMQQLDNPYIVRM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNII 472 + E +MQ L++P++V + + E +V+++ G L +LQQN H K++ + Sbjct: 59 VRNVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVK 118 Query: 473 ELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHG 532 + ++ M + YL+ +HRD+ N+LL + I+DF ++ L + T Sbjct: 119 LFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQI----TTM 174 Query: 533 KWPVKWYAPECINYYK---FSSKSDVWSFGVLMWEAFSYGQKPYR---GMKGSEVTAMLE 586 + APE + K +S D WS GV +E G++PY E+ E Sbjct: 175 AGTKPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELL-RGRRPYHIRSSTSSKEIVHTFE 233 Query: 587 KGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 + P+ +EM L+ + + R F+ + Y + +N Sbjct: 234 T-TVVTYPSAWSQEMVSLLKKLLEPNPDQR--FSQLSDVQNFPYMNDIN 279 >5HVK-A nrPDB Length = 315 Score = 221 bits (563), Expect = 8e-58, Method: Composition-based stats. Identities = 67/289 (23%), Positives = 117/289 (40%), Gaps = 28/289 (9%) Query: 359 RPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELL 418 RP ++ L+ + LG G FG K ++ + + + +K L D + L Sbjct: 6 RPHRIFRPSDLI--HGEVLGKGCFGQAIKVTHR--ETGEVMVMKEL--IRFDEETQRTFL 59 Query: 419 AEANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQ-NRHVKDKNIIELVH 476 E VM+ L++P +++ IG+ + + + E + G L ++ + + Sbjct: 60 KEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAK 119 Query: 477 QVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENY----------- 525 ++ GM YL N +HR+L + N L+ ++DFGL++ + ++ Sbjct: 120 DIASGMAYLHSMNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPD 179 Query: 526 YKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSY-----GQKPYRGMKGSE 580 K + W APE IN + K DV+SFG+++ E P G Sbjct: 180 RKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLN 239 Query: 581 VTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNY 629 V L++ CP CP + + C D E RP F +E L Sbjct: 240 VRGFLDR----YCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETL 284 >4TPT-A nrPDB Length = 303 Score = 221 bits (563), Expect = 9e-58, Method: Composition-based stats. Identities = 70/283 (24%), Positives = 114/283 (40%), Gaps = 35/283 (12%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPY 431 + + LG G FG K + K K + +K L D + L E VM+ LD+P Sbjct: 3 IHGEVLGKGFFGQAIKVTH--KATGKVMVMKEL--IRCDEETQKTFLTEVKVMRSLDHPN 58 Query: 432 IVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 +++ IG+ + + L+ E E G L +L+ + + ++ GM YL Sbjct: 59 VLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCI 118 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRAD-----------------ENYYKAQTHGK 533 +HRDL + N L+ ++DFGLS+ + + +N K + Sbjct: 119 IHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVV 178 Query: 534 WPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQ-------KPYRGMKGSEVTAMLE 586 W APE +N + D++SFG+++ E GQ P G V E Sbjct: 179 GNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII--GQVYADPDCLPRTLDFGLNVKLFWE 236 Query: 587 KGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNY 629 K P CP + L +C + E+RP F+ +E Sbjct: 237 KF----VPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEAL 275 >5WAX-A nrPDB Length = 310 Score = 220 bits (561), Expect = 1e-57, Method: Composition-based stats. Identities = 63/282 (22%), Positives = 105/282 (37%), Gaps = 25/282 (8%) Query: 366 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 425 DR L +++GSGNFG + + + VAVK + + + + E + Sbjct: 11 DRYELV---RDIGSGNFGVARLMRNRAD--GQLVAVKYI---ERGEKIDENVQREIINHR 62 Query: 426 QLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKY 484 L +P I+R + + + +VME A G L + + + Q+ G+ Y Sbjct: 63 SLRHPNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 122 Query: 485 LEESNFVHRDLAARNVLLV--TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 542 HRDL N LL T KI DFG SK + + APE Sbjct: 123 CHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSK----SSVLHSQPKSTVGTPAYIAPE 178 Query: 543 CINYYKFSSKS-DVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK---GERMGCPA--G 596 + ++ K DVWS GV ++ G P+ + + G + P Sbjct: 179 VLLKKEYDGKVADVWSCGVTLYVML-VGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVH 237 Query: 597 CPREMYDLMNLCWTYDVENRPGFAAVELR---LRNYYYDVVN 635 E DL++ + + R + L+N D+++ Sbjct: 238 ISPECQDLISRIFVANPATRITIPEIRNHPWFLKNLPADLMD 279 >5LOH-A nrPDB Length = 341 Score = 220 bits (560), Expect = 2e-57, Method: Composition-based stats. Identities = 68/310 (21%), Positives = 121/310 (39%), Gaps = 24/310 (7%) Query: 324 EPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFG 383 P + P A K + V P I + K + G FG Sbjct: 1 GPHMDPTAGSKKEPGGGAATEEGVNRIAVPKPPSIEEFSIV----------KPISRGAFG 50 Query: 384 TVKKGYYQMKKVVKTVAVKILKN-EANDPALKDELLAEANVMQQLDNPYIVRMIGICEA- 441 V G +K K AVK++K + + + ++ AE + + +P+IV + ++ Sbjct: 51 KVYLG----QKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSA 106 Query: 442 ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVL 501 + LVME G + L + ++ ++ + +V++ + YL +HRDL N+L Sbjct: 107 NNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNML 166 Query: 502 LVTQHYAKISDFGLSK-ALRADENYYKAQTHGK--WPVKWYAPECINYYKFSSKSDVWSF 558 + + + K++DFGLSK L D N T + APE + D W+ Sbjct: 167 ISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPELLLGRAHGPAVDWWAL 226 Query: 559 GVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAG---CPREMYDLMNLCWTYDVEN 615 GV ++E + G P+ +V + K + + P G + + T D Sbjct: 227 GVCLFEFLT-GIPPFNDETPQQVFQNILKRD-IPWPEGEEKLSDNAQSAVEILLTIDDTK 284 Query: 616 RPGFAAVELR 625 R G ++ Sbjct: 285 RAGMKELKRH 294 >5YV8-A nrPDB Length = 298 Score = 220 bits (560), Expect = 2e-57, Method: Composition-based stats. Identities = 57/287 (19%), Positives = 126/287 (43%), Gaps = 41/287 (14%) Query: 371 TLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPAL----------------- 413 TL+D+ +G G++G VK Y + A+K+L + Sbjct: 16 TLKDE-IGKGSYGVVKLAYNENDNT--YYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 72 Query: 414 -------KDELLAEANVMQQLDNPYIVRMIGICEA---ESWMLVMEMAELGPLNKYLQQN 463 +++ E ++++LD+P +V+++ + + + +V E+ GP+ + + Sbjct: 73 CIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME-VPTL 131 Query: 464 RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADE 523 + + + + G++YL +HRD+ N+L+ + KI+DFG+S + + Sbjct: 132 KPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSD 191 Query: 524 NYYKAQTHGKWPVKWYAPECINYYK--FSSKS-DVWSFGVLMWEAFSYGQKPYRGMKGSE 580 ++ + APE ++ + FS K+ DVW+ GV ++ F +GQ P+ + Sbjct: 192 ALL---SNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLY-CFVFGQCPFMDERIMC 247 Query: 581 VTAMLEKGERMGCP--AGCPREMYDLMNLCWTYDVENRPGFAAVELR 625 + + + K + + P ++ DL+ + E+R ++L Sbjct: 248 LHSKI-KSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLH 293 >1ZWS-A nrPDB Length = 288 Score = 219 bits (558), Expect = 3e-57, Method: Composition-based stats. Identities = 59/284 (20%), Positives = 119/284 (41%), Gaps = 25/284 (8%) Query: 357 EIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALK-- 414 E ++ D + +ELGSG F VKK + K A K +K + + + Sbjct: 3 EPFKQQKVEDFYDI---GEELGSGQFAIVKKC--REKSTGLEYAAKFIKKRQSRASRRGV 57 Query: 415 --DELLAEANVMQQLDNPYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNI 471 +E+ E ++++Q+ + ++ + + E + +L++E+ G L +L Q + ++ Sbjct: 58 SREEIEREVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEA 117 Query: 472 IELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQH----YAKISDFGLSKALRADENYYK 527 + Q+ G+ YL H DL N++L+ ++ + K+ DFGL+ + + Sbjct: 118 TSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEF-- 175 Query: 528 AQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 + ++ APE +NY ++D+WS GV+ + S G P+ G E A + Sbjct: 176 --KNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLS-GASPFLGDTKQETLANITS 232 Query: 588 GER---MGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 + D + + R ++ LR+ Sbjct: 233 VSYDFDEEFFSHTSELAKDFIRKLLVKETRKRLT---IQEALRH 273 >3TAC-A nrPDB Length = 361 Score = 219 bits (558), Expect = 3e-57, Method: Composition-based stats. Identities = 52/258 (20%), Positives = 104/258 (40%), Gaps = 21/258 (8%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPA---LKDELLAEANVMQQLDNPY 431 + +G G F V++ + + + AVKI+ + ++L EA++ L +P+ Sbjct: 32 EVIGKGPFSVVRRCINR--ETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPH 89 Query: 432 IVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRH----VKDKNIIELVHQVSMGMKYLE 486 IV ++ ++ +V E + L + + + + Q+ ++Y Sbjct: 90 IVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCH 149 Query: 487 ESNFVHRDLAARNVLLVTQHY---AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPEC 543 ++N +HRD+ VLL ++ K+ FG++ ++ E+ A P + APE Sbjct: 150 DNNIIHRDVKPHCVLLASKENSAPVKLGGFGVA--IQLGESGLVAGGRVGTP-HFMAPEV 206 Query: 544 INYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE---RMGCPAGCPRE 600 + + DVW GV+++ S G P+ G K + + KG+ + Sbjct: 207 VKREPYGKPVDVWGCGVILFILLS-GCLPFYGTK-ERLFEGIIKGKYKMNPRQWSHISES 264 Query: 601 MYDLMNLCWTYDVENRPG 618 DL+ D R Sbjct: 265 AKDLVRRMLMLDPAERIT 282 >2A27-A nrPDB Length = 321 Score = 219 bits (557), Expect = 3e-57, Method: Composition-based stats. Identities = 59/284 (20%), Positives = 119/284 (41%), Gaps = 25/284 (8%) Query: 357 EIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALK-- 414 E ++ D + +ELGSG F VKK + K A K +K + + + Sbjct: 3 EPFKQQKVEDFYDI---GEELGSGQFAIVKKC--REKSTGLEYAAKFIKKRQSRASRRGV 57 Query: 415 --DELLAEANVMQQLDNPYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNI 471 +E+ E ++++Q+ + ++ + + E + +L++E+ G L +L Q + ++ Sbjct: 58 SREEIEREVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEA 117 Query: 472 IELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQH----YAKISDFGLSKALRADENYYK 527 + Q+ G+ YL H DL N++L+ ++ + K+ DFGL+ + + Sbjct: 118 TSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEF-- 175 Query: 528 AQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 + ++ APE +NY ++D+WS GV+ + S G P+ G E A + Sbjct: 176 --KNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLS-GASPFLGDTKQETLANITA 232 Query: 588 GER---MGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 + D + + R ++ LR+ Sbjct: 233 VSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLT---IQEALRH 273 >3UC3-A nrPDB Length = 361 Score = 218 bits (556), Expect = 4e-57, Method: Composition-based stats. Identities = 65/282 (23%), Positives = 111/282 (39%), Gaps = 25/282 (8%) Query: 366 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 425 DR K++GSGNFG + ++ K + VAVK ++ A A+ + + E + Sbjct: 20 DRYDFV---KDIGSGNFGVARLMRDKLTK--ELVAVKYIERGA---AIDENVQREIINHR 71 Query: 426 QLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKY 484 L +P IVR + + + ++ME A G L + + + Q+ G+ Y Sbjct: 72 SLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSY 131 Query: 485 LEESNFVHRDLAARNVLLVTQ--HYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 542 HRDL N LL KI DFG SK + + APE Sbjct: 132 CHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK----SSVLHSQPKSTVGTPAYIAPE 187 Query: 543 CINYYKFSSK-SDVWSFGVLMWEAFSYGQKPYRG-MKGSEVTAMLEKGE--RMGCPAG-- 596 + ++ K +DVWS GV ++ G P+ + + +++ + P Sbjct: 188 VLLRQEYDGKIADVWSCGVTLYVML-VGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIR 246 Query: 597 CPREMYDLMNLCWTYDVENRPGFAAVELR---LRNYYYDVVN 635 E L++ + D R ++ L+N D++N Sbjct: 247 ISPECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMN 288 >4F0G-A nrPDB Length = 287 Score = 218 bits (556), Expect = 5e-57, Method: Composition-based stats. Identities = 74/274 (27%), Positives = 129/274 (47%), Gaps = 28/274 (10%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKIL-----KNEANDPALKDELLAEANVMQQLD 428 +K++G G FG V KG K V VA+K L + E E E +M L+ Sbjct: 24 EKQIGKGGFGLVHKGRLVKDKSV--VAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLN 81 Query: 429 NPYIVRMIGICEAESWMLVMEMAELGPLNK-YLQQNRHVKDKNIIELVHQVSMGMKYLEE 487 +P IV++ G+ +VME G L L + +K + L+ +++G++Y++ Sbjct: 82 HPNIVKLYGLMHNPPR-MVMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLDIALGIEYMQN 140 Query: 488 SN--FVHRDLAARNVLLVTQHY-----AKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540 N VHRDL + N+ L + AK++DFGLS+ + + +W A Sbjct: 141 QNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQ------SVHSVSGLLGNFQWMA 194 Query: 541 PECI--NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV--TAML-EKGERMGCPA 595 PE I ++ K+D +SF ++++ + G+ P+ ++ M+ E+G R P Sbjct: 195 PETIGAEEESYTEKADTYSFAMILYTILT-GEGPFDEYSYGKIKFINMIREEGLRPTIPE 253 Query: 596 GCPREMYDLMNLCWTYDVENRPGFAAVELRLRNY 629 CP + +++ LCW+ D + RP F+ + L Sbjct: 254 DCPPRLRNVIELCWSGDPKKRPHFSYIVKELSEL 287 >6GU6-A nrPDB Length = 302 Score = 218 bits (555), Expect = 6e-57, Method: Composition-based stats. Identities = 61/296 (20%), Positives = 128/296 (43%), Gaps = 47/296 (15%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +++G G +G V KG + K + VA+K ++ E+ + + + E +++++L +P IV Sbjct: 13 EKIGEGTYGVVYKGRH--KTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVS 70 Query: 435 MIGICEAES-WMLVMEMAELGPLNKYLQQ---NRHVKDKNIIELVHQVSMGMKYLEESNF 490 + + +S L+ E + L KYL +++ + ++Q+ G+ + Sbjct: 71 LQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRV 129 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY-KF 549 +HRDL +N+L+ + K++DFGL++A Y TH + + +PE + ++ Sbjct: 130 LHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY---THEVVTLWYRSPEVLLGSARY 186 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAG-CPREMY------ 602 S+ D+WS G + E + + + G SE+ + +G P E+ Sbjct: 187 STPVDIWSIGTIFAELATK-KPLFHG--DSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 243 Query: 603 -----------------------DLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 DL++ YD R ++ L + Y++ ++ Sbjct: 244 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS---GKMALNHPYFNDLD 296 >4KS7-A nrPDB Length = 292 Score = 218 bits (555), Expect = 7e-57, Method: Composition-based stats. Identities = 55/263 (20%), Positives = 102/263 (38%), Gaps = 12/263 (4%) Query: 366 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 425 D +LL ++G G+ G V + K + VAVK++ + ++ L E +M+ Sbjct: 20 DPRLLLDSYVKIGEGSTGIVCLA--REKHSGRQVAVKMM--DLRKQQRRELLFNEVVIMR 75 Query: 426 QLDNPYIVRMI-GICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKY 484 + +V M E ++ME + G L + + ++ I + V + Y Sbjct: 76 DYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTD-IVSQVRLNEEQIATVCEAVLQALAY 134 Query: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 L +HRD+ + ++LL K+SDFG + D K+ W APE I Sbjct: 135 LHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLV---GTPYWMAPEVI 191 Query: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGC--PAGCPREMY 602 + ++++ D+WS G+++ E G+ PY + L + Sbjct: 192 SRSLYATEVDIWSLGIMVIEMV-DGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLR 250 Query: 603 DLMNLCWTYDVENRPGFAAVELR 625 D + D + R + Sbjct: 251 DFLERMLVRDPQERATAQELLDH 273 >4AU8-A nrPDB Length = 296 Score = 217 bits (554), Expect = 8e-57, Method: Composition-based stats. Identities = 64/292 (21%), Positives = 125/292 (42%), Gaps = 46/292 (15%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +++G G +GTV K + ++ + VA+K ++ + +D + L E ++++L + IVR Sbjct: 12 EKIGEGTYGTVFKA--KNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVR 69 Query: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQ-NRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 + + ++ + LV E + L KY N + + + + Q+ G+ + N +H Sbjct: 70 LHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLH 128 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK-FSS 551 RDL +N+L+ K++DFGL++A Y A+ W + P+ + K +S+ Sbjct: 129 RDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW---YRPPDVLFGAKLYST 185 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERM-------------GCPAGCP 598 D+WS G + E + G+ + G ++V L++ R+ P P Sbjct: 186 SIDMWSAGCIFAELANAGRPLFPG---NDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 242 Query: 599 REMY------------------DLMNLCWTYDVENRPGFAAVELRLRNYYYD 632 MY DL+ + R E L++ Y+ Sbjct: 243 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISA---EEALQHPYFS 291 >3FI2-A nrPDB Length = 353 Score = 217 bits (554), Expect = 9e-57, Method: Composition-based stats. Identities = 63/255 (24%), Positives = 112/255 (43%), Gaps = 22/255 (8%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K +GSG G V Y + + + VA+K L + E +M+ +++ I+ Sbjct: 30 KPIGSGAQGIVCAAYDAV--LDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS 87 Query: 435 MIGIC-------EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 487 ++ + E + LVME+ + L + +Q + + + L++Q+ G+K+L Sbjct: 88 LLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME--LDHERMSYLLYQMLCGIKHLHS 144 Query: 488 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY 547 + +HRDL N+++ + KI DFGL++ T + APE I Sbjct: 145 AGIIHRDLKPSNIVVKSDCTLKILDFGLART----AGTSFMMTPYVVTRYYRAPEVILGM 200 Query: 548 KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNL 607 + D+WS G +M E + + + G + + E++G P CP M L Sbjct: 201 GYKENVDIWSVGCIMGEMVRH-KILFPGRDYIDQWNKV--IEQLGTP--CPEFMKKLQPT 255 Query: 608 CWTYDVENRPGFAAV 622 Y VENRP +A + Sbjct: 256 VRNY-VENRPKYAGL 269 >1JNK-A nrPDB Length = 423 Score = 217 bits (554), Expect = 9e-57, Method: Composition-based stats. Identities = 63/255 (24%), Positives = 112/255 (43%), Gaps = 22/255 (8%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K +GSG G V Y + + + VA+K L + E +M+ +++ I+ Sbjct: 68 KPIGSGAQGIVCAAYDAV--LDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS 125 Query: 435 MIGIC-------EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 487 ++ + E + LVME+ + L + +Q + + + L++Q+ G+K+L Sbjct: 126 LLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME--LDHERMSYLLYQMLCGIKHLHS 182 Query: 488 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY 547 + +HRDL N+++ + KI DFGL++ T + APE I Sbjct: 183 AGIIHRDLKPSNIVVKSDCTLKILDFGLART----AGTSFMMTPYVVTRYYRAPEVILGM 238 Query: 548 KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNL 607 + D+WS G +M E + + + G + + E++G P CP M L Sbjct: 239 GYKENVDIWSVGCIMGEMVRH-KILFPGRDYIDQWNKV--IEQLGTP--CPEFMKKLQPT 293 Query: 608 CWTYDVENRPGFAAV 622 Y VENRP +A + Sbjct: 294 VRNY-VENRPKYAGL 307 >1KOB-A nrPDB Length = 387 Score = 217 bits (553), Expect = 1e-56, Method: Composition-based stats. Identities = 63/288 (21%), Positives = 116/288 (40%), Gaps = 20/288 (6%) Query: 345 TEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKIL 404 ++++ P E++ VY +L +ELGSG FG V + K + K + Sbjct: 31 EDIWKKYVPQPVEVKQGSVYDYYDIL----EELGSGAFGVVHRCV--EKATGRVFVAKFI 84 Query: 405 KNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQ-Q 462 P K + E ++M QL +P ++ + E + M L++E G L + + Sbjct: 85 NTPY--PLDKYTVKNEISIMNQLHHPKLINLHDAFEDKYEMVLILEFLSGGELFDRIAAE 142 Query: 463 NRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQ--HYAKISDFGLSKALR 520 + + + +I + Q G+K++ E + VH D+ N++ T+ KI DFGL+ L Sbjct: 143 DYKMSEAEVINYMRQACEGLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLN 202 Query: 521 ADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSE 580 DE ++ APE ++ +D+W+ GVL + S G P+ G E Sbjct: 203 PDE----IVKVTTATAEFAAPEIVDREPVGFYTDMWAIGVLGYVLLS-GLSPFAGEDDLE 257 Query: 581 VTAMLEKGERMGCP---AGCPREMYDLMNLCWTYDVENRPGFAAVELR 625 +++ + + E D + + R Sbjct: 258 TLQNVKRCDWEFDEDAFSSVSPEAKDFIKNLLQKEPRKRLTVHDALEH 305 >2XS0-A nrPDB Length = 386 Score = 217 bits (552), Expect = 1e-56, Method: Composition-based stats. Identities = 63/254 (24%), Positives = 110/254 (43%), Gaps = 22/254 (8%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K +GSG G V Y + + + VA+K L + E +M+ +++ I+ Sbjct: 32 KPIGSGAQGIVCAAYDAI--LERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIG 89 Query: 435 MIGIC-------EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 487 ++ + E + +VME+ + L + +Q + + + L++Q+ G+K+L Sbjct: 90 LLNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQME--LDHERMSYLLYQMLCGIKHLHS 146 Query: 488 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY 547 + +HRDL N+++ + KI DFGL++ + APE I Sbjct: 147 AGIIHRDLKPSNIVVKSDCTLKILDFGLART----AGTSFMMVPFVVTRYYRAPEVILGM 202 Query: 548 KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNL 607 + D+WS G +M E G + G + + E++G P CP M L Sbjct: 203 GYKENVDIWSVGCIMGEMI-KGGVLFPGTD--HIDQWNKVIEQLGTP--CPEFMKKLQPT 257 Query: 608 CWTYDVENRPGFAA 621 TY VENRP +A Sbjct: 258 VRTY-VENRPKYAG 270 >5AWM-A nrPDB Length = 394 Score = 216 bits (551), Expect = 2e-56, Method: Composition-based stats. Identities = 61/257 (23%), Positives = 107/257 (41%), Gaps = 22/257 (8%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPY 431 + + +GSG G V Y + + VA+K L + E +M+ +++ Sbjct: 47 INLRPIGSGAQGIVCAAYDTI--TQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 104 Query: 432 IVRMIGIC-------EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKY 484 I+ ++ E + LVME+ + L + +Q + + L++Q+ G+K+ Sbjct: 105 IIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQ--MDLDHDRMSYLLYQMLCGIKH 161 Query: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 L + +HRDL N+++ KI DFGL++ T + APE I Sbjct: 162 LHSAGIIHRDLKPSNIVVKADCTLKILDFGLART----AGTTFMMTPYVVTRYYRAPEVI 217 Query: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDL 604 ++ D+WS G +M E G + G + + E++G P+ P M L Sbjct: 218 LGMGYTENVDIWSVGCIMGEMI-RGGVLFPGTD--HIDQWNKIIEQLGTPS--PSFMQRL 272 Query: 605 MNLCWTYDVENRPGFAA 621 Y VENRP + Sbjct: 273 QPTVRNY-VENRPRYTG 288 >5EFQ-A nrPDB Length = 347 Score = 216 bits (551), Expect = 2e-56, Method: Composition-based stats. Identities = 57/287 (19%), Positives = 111/287 (38%), Gaps = 48/287 (16%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G G +G V K K + VA+K ++ + + E +++QL + I+ M Sbjct: 19 IGEGTYGQVYKARD--KDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMK 76 Query: 437 GICEAES-----------WMLVMEMAELGPLNKYLQQN-RHVKDKNIIELVHQVSMGMKY 484 I + + LV E + L L+ H + +I + Q+ G+ Y Sbjct: 77 EIVTDKEDALDFKKDKGAFYLVFEYMDH-DLMGLLESGLVHFNENHIKSFMRQLMEGLDY 135 Query: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 + NF+HRD+ N+LL + K++DFGL++ ++E+ + T+ + + PE + Sbjct: 136 CHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEES--RPYTNKVITLWYRPPELL 193 Query: 545 NY-YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY- 602 +++ DVWS G ++ E F+ + ++ + ++ + CPA P + Sbjct: 194 LGEERYTPAIDVWSCGCILGELFTK-KPIFQANQELAQLELISRICGSPCPAVWPDVIKL 252 Query: 603 ----------------------------DLMNLCWTYDVENRPGFAA 621 DL + D R Sbjct: 253 PYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQ 299 >4B8L-A nrPDB Length = 286 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 62/268 (23%), Positives = 110/268 (41%), Gaps = 15/268 (5%) Query: 364 YLDRKLLTLED----KELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELL 418 + ++ T++D + LG G FG V + K +A+K+L K++ ++ +L Sbjct: 6 EMPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKF--IMALKVLFKSQLEKEGVEHQLR 63 Query: 419 AEANVMQQLDNPYIVRMIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQ 477 E + L +P I+RM + L++E A G L K LQ++ ++ + + Sbjct: 64 REIEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEE 123 Query: 478 VSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVK 537 ++ + Y E +HRD+ N+L+ + KI+DFG S + T + Sbjct: 124 LADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGT-----LD 178 Query: 538 WYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGC 597 + PE I K D+W GVL +E F G P+ +E + + + P Sbjct: 179 YLPPEMIEGKTHDEKVDLWCAGVLCYE-FLVGMPPFDSPSHTETHRRIVNVD-LKFPPFL 236 Query: 598 PREMYDLMNLCWTYDVENRPGFAAVELR 625 DL++ Y R V Sbjct: 237 SDGSKDLISKLLRYHPPQRLPLKGVMEH 264 >5WNL-A nrPDB Length = 342 Score = 215 bits (548), Expect = 5e-56, Method: Composition-based stats. Identities = 78/266 (29%), Positives = 122/266 (45%), Gaps = 16/266 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +++GSG FG V K + K +A+K + D + ELL EA M+ YI+ Sbjct: 26 EKVGSGGFGQVYKVRHVHWKT--WLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILP 83 Query: 435 MIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE--ESNFVH 492 + GIC+ E LVME E G L K L + + +VH+ ++GM +L +H Sbjct: 84 VYGICQ-EPVGLVMEYMETGSLEKLL-ASEPLPWDLRFRIVHETAVGMNFLHCMSPPLLH 141 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK--FS 550 +L N+LL ++ KISDFGL+K ++ + + + PE I F Sbjct: 142 LNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKSRLFD 201 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKG-SEVTAMLEKGERMGCPAGC-PRE-----MYD 603 +K DV+SF +++W + +KP+ K + + KG R P C PR + Sbjct: 202 TKHDVYSFAIVIWGVLTQ-KKPFADEKNILHIMMKVVKGHRPELPPICRPRPRACASLIG 260 Query: 604 LMNLCWTYDVENRPGFAAVELRLRNY 629 LM CW D + RP F + + Sbjct: 261 LMQRCWHADPQVRPTFQEITSETEDL 286 >5Z33-A nrPDB Length = 425 Score = 215 bits (547), Expect = 5e-56, Method: Composition-based stats. Identities = 62/308 (20%), Positives = 115/308 (37%), Gaps = 46/308 (14%) Query: 357 EIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE 416 ++ ++ +D + KELG G +G V + + VA+K + N + L Sbjct: 21 KVFNQDFIVDERYTV--TKELGQGAYGIVCAAVNN--QTSEGVAIKKVTNVFSKKILAKR 76 Query: 417 LLAEANVMQQLD-NPYIVRMIG--ICEAESW---MLVMEMAELGPLNKYLQQNRHVKDKN 470 L E ++Q + I + I +++ L E+ E L ++ + + D + Sbjct: 77 ALREIKLLQHFRGHRNITCLYDMDIPRPDNFNETYLYEELMEC-DLAAIIRSGQPLTDAH 135 Query: 471 IIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQT 530 ++Q+ G+KY+ +N +HRDL N+L+ KI DFGL++ D Sbjct: 136 FQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYM 195 Query: 531 HGKWPVKWY-APEC-INYYKFSSKSDVWSFGVLMWEAFSYGQKPYR-------------- 574 +WY APE +++ ++ DVWS G ++ E G +P+ Sbjct: 196 TEYVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELL--GGRPFFKGRDYVDQLNQILH 253 Query: 575 --GMKGSEVTAMLEKGERM------------GCPAGCP---REMYDLMNLCWTYDVENRP 617 G E + + P P + DL++ +D +R Sbjct: 254 ILGTPNEETLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRI 313 Query: 618 GFAAVELR 625 Sbjct: 314 SVEQALEH 321 >3UTO-A nrPDB Length = 573 Score = 215 bits (547), Expect = 6e-56, Method: Composition-based stats. Identities = 65/290 (22%), Positives = 120/290 (41%), Gaps = 23/290 (7%) Query: 346 EVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILK 405 ++++ Y P EI+ V LD + +ELG+G FG V + + A K + Sbjct: 138 DIWKQYYPQPVEIKHDHV-LDHYDI---HEELGTGAFGVVHR--VTERATGNNFAAKFVM 191 Query: 406 NEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYL-QQN 463 K+ + E M L +P +V + E ++ M ++ E G L + + ++ Sbjct: 192 TPHES--DKETVRKEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEH 249 Query: 464 RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQ--HYAKISDFGLSKALRA 521 + + +E + QV G+ ++ E+N+VH DL N++ T+ + K+ DFGL+ L Sbjct: 250 NKMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDP 309 Query: 522 DENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 ++ ++ APE +D+WS GVL + S G P+ G E Sbjct: 310 KQSV----KVTTGTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLS-GLSPFGGENDDET 364 Query: 582 TAMLEKGE-RMGCP--AGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 ++ + M +G + D + D R + L + Sbjct: 365 LRNVKSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTR---MTIHQALEH 411 >3ORZ-A nrPDB Length = 316 Score = 215 bits (547), Expect = 6e-56, Method: Composition-based stats. Identities = 59/266 (22%), Positives = 112/266 (42%), Gaps = 10/266 (3%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE-LLAEANVMQQLDNPYI 432 K LG G+F TV + A+KIL+ K + E +VM +LD+P+ Sbjct: 42 GKILGEGSFSTVVLARELA--TSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFF 99 Query: 433 VRMIGICEAE-SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFV 491 V++ + + + A+ G L KY+++ + ++ ++YL + Sbjct: 100 VKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGII 159 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 HRDL N+LL + +I+DFG +K L + +A + ++ +PE + Sbjct: 160 HRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSF-VGTAQYVSPELLTEKSACK 218 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 611 SD+W+ G ++++ + G P+R + + K E P + DL+ Sbjct: 219 SSDLWALGCIIYQLVA-GLPPFRAGNEYLIFQKIIKLE-YDFPEKFFPKARDLVEKLLVL 276 Query: 612 DVENRPGFAAVE---LRLRNYYYDVV 634 D R G +E + +++ V Sbjct: 277 DATKRLGCEEMEGYGPLKAHPFFESV 302 >1V0B-A nrPDB Length = 288 Score = 215 bits (547), Expect = 6e-56, Method: Composition-based stats. Identities = 58/288 (20%), Positives = 113/288 (39%), Gaps = 42/288 (14%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +++G G +G V K +T A+K ++ E D + + E +++++L + IV+ Sbjct: 8 EKIGEGTYGVVYKA---QNNYGETFALKKIRLEKEDEGIPSTTIREISILKELKHSNIVK 64 Query: 435 MIGICEAES-WMLVMEMAELGPLNKYLQ-QNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 + + + +LV E + L K L ++ + Q+ G+ Y + +H Sbjct: 65 LYDVIHTKKRLVLVFEHLDQ-DLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRRVLH 123 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY-YKFSS 551 RDL +N+L+ + KI+DFGL++A Y TH + + AP+ + K+S+ Sbjct: 124 RDLKPQNLLINREGELKIADFGLARAFGIPVRKY---THEVVTLWYRAPDVLMGSKKYST 180 Query: 552 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG----------ERMGCPAGCP--- 598 D+WS G + E + G + G+ ++ + + P P Sbjct: 181 TIDIWSVGCIFAEMVN-GAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPNFT 239 Query: 599 ---------------REMYDLMNLCWTYDVENRPGFAAVELRLRNYYY 631 DL++ D R L + Y+ Sbjct: 240 VYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQ---ALEHAYF 284 >6E2O-A nrPDB Length = 295 Score = 214 bits (545), Expect = 8e-56, Method: Composition-based stats. Identities = 62/250 (24%), Positives = 103/250 (41%), Gaps = 17/250 (6%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 LG G +G V G +V +A+K + D L E + + L + IV+ Sbjct: 29 VLGKGTYGIVYAGRDLSNQV--RIAIKEI--PERDSRYSQPLHEEIALHKHLKHKNIVQY 84 Query: 436 IGICEAESWM-LVMEMAELGPLNKYLQQNRHV---KDKNIIELVHQVSMGMKYLEESNFV 491 +G ++ + ME G L+ L+ ++ I Q+ G+KYL ++ V Sbjct: 85 LGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIV 144 Query: 492 HRDLAARNVLLVT-QHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK-- 548 HRD+ NVL+ T KISDFG SK L + T +++ APE I+ Sbjct: 145 HRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFT---GTLQYMAPEIIDKGPRG 201 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYR--GMKGSEVTAMLEKGERMGCPAGCPREMYDLMN 606 + +D+WS G + E + G+ P+ G + + + P E + Sbjct: 202 YGKAADIWSLGCTIIEMAT-GKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFIL 260 Query: 607 LCWTYDVENR 616 C+ D + R Sbjct: 261 KCFEPDPDKR 270 >3ZUT-A nrPDB Length = 362 Score = 214 bits (545), Expect = 1e-55, Method: Composition-based stats. Identities = 64/282 (22%), Positives = 105/282 (37%), Gaps = 25/282 (8%) Query: 366 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 425 DR L K++GSGNFG + + K+ + VAVK + + + + E + Sbjct: 19 DRYELV---KDIGSGNFGVARL--MRDKQSNELVAVKYI---ERGEKIDENVKREIINHR 70 Query: 426 QLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKY 484 L +P IVR + + + +VME A G L + + + Q+ G+ Y Sbjct: 71 SLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 Query: 485 LEESNFVHRDLAARNVLLVTQ--HYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 542 HRDL N LL KI FG SK + + APE Sbjct: 131 CHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSK----SSVLHSQPKSTVGTPAYIAPE 186 Query: 543 CINYYKFSSKS-DVWSFGVLMWEAFSYGQKPYRGMKGSE-----VTAMLEKGERMGCPAG 596 + ++ K DVWS GV ++ G P+ + + + +L + Sbjct: 187 VLLKKEYDGKVADVWSCGVTLYVML-VGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH 245 Query: 597 CPREMYDLMNLCWTYDVENRPGFAAVELR---LRNYYYDVVN 635 E L++ + D R + L+N D++N Sbjct: 246 ISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMN 287 >5D7A-A nrPDB Length = 308 Score = 213 bits (543), Expect = 1e-55, Method: Composition-based stats. Identities = 57/267 (21%), Positives = 107/267 (40%), Gaps = 25/267 (9%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL-DNPYIV 433 + +G+G +G V KG + K + A+K++ ++ +E+ E N++++ + I Sbjct: 23 ELVGNGTYGQVYKGRHV--KTGQLAAIKVMDVTGDEE---EEIKQEINMLKKYSHHRNIA 77 Query: 434 RMIGICE-------AESWMLVMEMAELGPLNKYLQQNRH--VKDKNIIELVHQVSMGMKY 484 G + LVME G + ++ + +K++ I + ++ G+ + Sbjct: 78 TYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSH 137 Query: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 L + +HRD+ +NVLL K+ DFG+S L D + T P W APE I Sbjct: 138 LHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQL--DRTVGRRNTFIGTPY-WMAPEVI 194 Query: 545 N-----YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGC-PAGCP 598 + KSD+WS G+ E + G P M ++ + Sbjct: 195 ACDENPDATYDFKSDLWSLGITAIEM-AEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWS 253 Query: 599 REMYDLMNLCWTYDVENRPGFAAVELR 625 ++ + C + RP + Sbjct: 254 KKFQSFIESCLVKNHSQRPATEQLMKH 280 >4KRC-A nrPDB Length = 317 Score = 213 bits (543), Expect = 1e-55, Method: Composition-based stats. Identities = 60/253 (23%), Positives = 118/253 (46%), Gaps = 23/253 (9%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 ++LG+G + TV KG K VA+K +K ++ + + E ++M++L + IVR Sbjct: 11 EKLGNGTYATVYKGLN--KTTGVYVALKEVKLDS-EEGTPSTAIREISLMKELKHENIVR 67 Query: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQN------RHVKDKNIIELVHQVSMGMKYLEE 487 + + E+ + LV E + L KY+ R ++ + Q+ G+ + E Sbjct: 68 LYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHE 126 Query: 488 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY 547 + +HRDL +N+L+ + K+ DFGL++A N + ++ W + AP+ + Sbjct: 127 NKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLW---YRAPDVLMGS 183 Query: 548 K-FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMN 606 + +S+ D+WS G ++ E + G+ + G E ++ + MG P ++ + Sbjct: 184 RTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIF--DIMGTPN---ESLWPSVT 237 Query: 607 LCWTYDVE--NRP 617 Y+ RP Sbjct: 238 KLPKYNPNIQQRP 250 >3UDB-A nrPDB Length = 317 Score = 213 bits (543), Expect = 1e-55, Method: Composition-based stats. Identities = 65/282 (23%), Positives = 108/282 (38%), Gaps = 25/282 (8%) Query: 366 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 425 DR L K++G+GNFG + + K+ + VAVK + + + + E + Sbjct: 19 DRYELV---KDIGAGNFGVARL--MRDKQANELVAVKYI---ERGEKIDENVKREIINHR 70 Query: 426 QLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKY 484 L +P IVR + + + +VME A G L + + + Q+ G+ Y Sbjct: 71 SLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSY 130 Query: 485 LEESNFVHRDLAARNVLLVTQ--HYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 542 HRDL N LL KI+DFG SKA + + APE Sbjct: 131 AHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKA----SVLHSQPKSAVGTPAYIAPE 186 Query: 543 CINYYKFSSKS-DVWSFGVLMWEAFSYGQKPYRGMKGSE-----VTAMLEKGERMGCPAG 596 + ++ K DVWS GV ++ G P+ + + + +L + Sbjct: 187 VLLKKEYDGKVADVWSCGVTLYVML-VGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVH 245 Query: 597 CPREMYDLMNLCWTYDVENRPGFAAVELR---LRNYYYDVVN 635 E L++ + D R + L+N D++N Sbjct: 246 ISPECRHLISRIFVADPAKRISIPEIRNHEWFLKNLPADLMN 287 >1KOA-A nrPDB Length = 491 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 65/290 (22%), Positives = 120/290 (41%), Gaps = 23/290 (7%) Query: 346 EVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILK 405 ++++ Y P EI+ V LD + +ELG+G FG V + + A K + Sbjct: 32 DIWKQYYPQPVEIKHDHV-LDHYDI---HEELGTGAFGVVHR--VTERATGNNFAAKFVM 85 Query: 406 NEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYL-QQN 463 K+ + E M L +P +V + E ++ M ++ E G L + + ++ Sbjct: 86 TPHES--DKETVRKEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEH 143 Query: 464 RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQ--HYAKISDFGLSKALRA 521 + + +E + QV G+ ++ E+N+VH DL N++ T+ + K+ DFGL+ L Sbjct: 144 NKMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDP 203 Query: 522 DENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 ++ ++ APE +D+WS GVL + S G P+ G E Sbjct: 204 KQSV----KVTTGTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLS-GLSPFGGENDDET 258 Query: 582 TAMLEKGE-RMGCP--AGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 ++ + M +G + D + D R + L + Sbjct: 259 LRNVKSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTR---MTIHQALEH 305 >4AF3-A nrPDB Length = 292 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 64/268 (23%), Positives = 115/268 (42%), Gaps = 14/268 (5%) Query: 357 EIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKD 415 +I + +D + + LG G FG V + KK VA+K+L K++ ++ Sbjct: 14 DILTRHFTIDDFEI---GRPLGKGKFGNVYLA--REKKSHFIVALKVLFKSQIEKEGVEH 68 Query: 416 ELLAEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIEL 474 +L E + L +P I+R+ + L++E A G L K LQ++ ++ + Sbjct: 69 QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI 128 Query: 475 VHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKW 534 + +++ + Y +HRD+ N+LL + KI+DFG S + + Sbjct: 129 MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPS-----LRRKTMCG 183 Query: 535 PVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP 594 + + PE I + K D+W GVL +E G P+ +E + K + + P Sbjct: 184 TLDYLPPEMIEGRMHNEKVDLWCIGVLCYELL-VGNPPFESASHNETYRRIVKVD-LKFP 241 Query: 595 AGCPREMYDLMNLCWTYDVENRPGFAAV 622 A P DL++ ++ R A V Sbjct: 242 ASVPTGAQDLISKLLRHNPSERLPLAQV 269 >6ED6-A nrPDB Length = 415 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 56/266 (21%), Positives = 108/266 (40%), Gaps = 16/266 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKN-EANDPALKDELLAEANVMQQLDNPYIV 433 K +G G FG V+ ++ + K A+K+L E + E ++M ++P++V Sbjct: 94 KVIGRGAFGEVQLVRHKASQ--KVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVV 151 Query: 434 RMIGICEAESW-MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 ++ + + + +VME G L L N V +K +V + + + +H Sbjct: 152 QLFYAFQDDRYLYMVMEYMPGGDLVN-LMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIH 210 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK---- 548 RD+ N+LL + K++DFG ++ DE + +PE + Sbjct: 211 RDVKPDNMLLDKHGHLKLADFGTC--MKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGF 268 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAML-EKGERMGCPAG--CPREMYDLM 605 + + D WS GV ++E G P+ + + + + P + +L+ Sbjct: 269 YGRECDWWSVGVFLYEML-VGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLI 327 Query: 606 NLCWTYDVENRPGFAAVELRLRNYYY 631 T D E R G VE ++ ++ Sbjct: 328 CAFLT-DREVRLGRNGVEEIRQHPFF 352 >2HW6-A nrPDB Length = 307 Score = 212 bits (541), Expect = 3e-55, Method: Composition-based stats. Identities = 60/288 (20%), Positives = 112/288 (38%), Gaps = 39/288 (13%) Query: 371 TLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLD-N 429 L + LG G + V+ K AVKI++ +A + + E + Q N Sbjct: 15 KLTSELLGEGAYAKVQGAVSLQN--GKEYAVKIIEKQAGHS--RSRVFREVETLYQCQGN 70 Query: 430 PYIVRMIGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 I+ +I E ++ + LV E + G + ++Q+ +H ++ +V V+ + +L Sbjct: 71 KNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTK 130 Query: 489 NFVHRDLAARNVLLVTQHY---AKISDFGLSKALRADENYYKAQTHGKWPV----KWYAP 541 HRDL N+L + KI DF L ++ + + T ++ AP Sbjct: 131 GIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAP 190 Query: 542 ECI-----NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSE---------------V 581 E + + + D+WS GV+++ S G P+ G G++ + Sbjct: 191 EVVEVFTDQATFYDKRCDLWSLGVVLYIMLS-GYPPFVGHCGADCGWDRGEVCRVCQNKL 249 Query: 582 TAMLEKGERMGCPA----GCPREMYDLMNLCWTYDVENRPGFAAVELR 625 +++G+ P E DL++ D + R A V Sbjct: 250 FESIQEGK-YEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQH 296 >3E7O-A nrPDB Length = 360 Score = 212 bits (541), Expect = 3e-55, Method: Composition-based stats. Identities = 60/266 (22%), Positives = 113/266 (42%), Gaps = 24/266 (9%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K +GSG G V + + + VAVK L + E +++ +++ I+ Sbjct: 28 KPIGSGAQGIVCAAFDTV--LGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIIS 85 Query: 435 MIGIC-------EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 487 ++ + E + LVME+ + L + + + + + L++Q+ G+K+L Sbjct: 86 LLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIHME--LDHERMSYLLYQMLCGIKHLHS 142 Query: 488 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY 547 + +HRDL N+++ + KI DFGL++ + T + APE I Sbjct: 143 AGIIHRDLKPSNIVVKSDCTLKILDFGLART----ASTNFMMTPYVVTRYYRAPEVILGM 198 Query: 548 KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNL 607 + D+WS G +M E G ++G + + E++G P+ M L Sbjct: 199 GYKENVDIWSVGCIMGELV-KGSVIFQGTD--HIDQWNKVIEQLGTPSA--EFMAALQPT 253 Query: 608 CWTYDVENRPGFAAV--ELRLRNYYY 631 Y VENRP + + E ++ + Sbjct: 254 VRNY-VENRPAYPGIAFEELFPDWIF 278 >4AN9-A nrPDB Length = 301 Score = 212 bits (540), Expect = 3e-55, Method: Composition-based stats. Identities = 62/253 (24%), Positives = 122/253 (48%), Gaps = 12/253 (4%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 ELG+GN G V K ++ +V +A K++ E PA++++++ E V+ + ++PYIV Sbjct: 16 ELGAGNGGVVFKVSHKPSGLV--MARKLIHLEI-KPAIRNQIIRELQVLHECNSPYIVGF 72 Query: 436 IGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYL-EESNFVHR 493 G ++ + + ME + G L++ L++ + ++ + ++ V G+ YL E+ +HR Sbjct: 73 YGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHR 132 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKS 553 D+ N+L+ ++ K+ DFG+S L + T + +PE + +S +S Sbjct: 133 DVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTRS-----YMSPERLQGTHYSVQS 187 Query: 554 DVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAG-CPREMYDLMNLCWTYD 612 D+WS G+ + E + G+ P M E+ + P+ E D +N C + Sbjct: 188 DIWSMGLSLVEM-AVGRYPRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKN 246 Query: 613 VENRPGFAAVELR 625 R + + Sbjct: 247 PAERADLKQLMVH 259 >3C51-A nrPDB Length = 543 Score = 212 bits (540), Expect = 3e-55, Method: Composition-based stats. Identities = 65/304 (21%), Positives = 119/304 (39%), Gaps = 30/304 (9%) Query: 341 LPMDTEVYESPYADPEEIRPKEVYLDR-------------KLLTLEDKELGSGNFGTVKK 387 P+ V P + +Y R + L+ + LG G FG V Sbjct: 144 QPLLRAVLAHLGQAPFQEFLDSLYFLRFLQWKWLEAQPMGEDWFLDFRVLGRGGFGEVFA 203 Query: 388 GYYQMKKVVKTVAVKILKNEANDPALKDE-LLAEANVMQQLDNPYIVRMIGICEAES-WM 445 QMK K A K L + + + E ++ ++ + +IV + E ++ Sbjct: 204 C--QMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSLAYAFETKTDLC 261 Query: 446 LVMEMAELGPLNKYL----QQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVL 501 LVM + G + ++ + N ++ I Q+ G+++L + N ++RDL NVL Sbjct: 262 LVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVL 321 Query: 502 LVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVL 561 L +ISD GL+ L+A + K + APE + ++ D ++ GV Sbjct: 322 LDDDGNVRISDLGLAVELKAGQTKTKGY---AGTPGFMAPELLLGEEYDFSVDYFALGVT 378 Query: 562 MWEAFSYGQKPYRG----MKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRP 617 ++E + + P+R ++ E+ + + + + P D D E R Sbjct: 379 LYEMIAA-RGPFRARGEKVENKELKQRVLE-QAVTYPDKFSPASKDFCEALLQKDPEKRL 436 Query: 618 GFAA 621 GF Sbjct: 437 GFRD 440 >4NST-A nrPDB Length = 351 Score = 212 bits (540), Expect = 4e-55, Method: Composition-based stats. Identities = 58/287 (20%), Positives = 113/287 (39%), Gaps = 48/287 (16%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G G +G V K + K + VA+K ++ + + E +++QL + +V M Sbjct: 21 IGEGTYGQVYKA--KDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMK 78 Query: 437 GICEAES-----------WMLVMEMAELGPLNKYLQQN-RHVKDKNIIELVHQVSMGMKY 484 I + + LV E + L L+ H + +I + Q+ G++Y Sbjct: 79 EIVTDKQDALDFKKDKGAFYLVFEYMDH-DLMGLLESGLVHFSEDHIKSFMKQLMEGLEY 137 Query: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 + NF+HRD+ N+LL K++DFGL++ ++E+ + T+ + + PE + Sbjct: 138 CHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEES--RPYTNKVITLWYRPPELL 195 Query: 545 NY-YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY- 602 +++ DVWS G ++ E F+ + ++ ++ + CPA P + Sbjct: 196 LGEERYTPAIDVWSCGCILGELFTK-KPIFQANLELAQLELISRLCGSPCPAVWPDVIKL 254 Query: 603 ----------------------------DLMNLCWTYDVENRPGFAA 621 DL++ T D R Sbjct: 255 PYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQ 301 >3ZDU-A nrPDB Length = 325 Score = 212 bits (540), Expect = 4e-55, Method: Composition-based stats. Identities = 55/288 (19%), Positives = 117/288 (40%), Gaps = 42/288 (14%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 ++G G++GTV K + K + VA+KI E + ++ + E ++Q + +V + Sbjct: 10 KVGEGSYGTVMKCKH--KNTGQIVAIKIF-YERPEQSVNKIAMREIKFLKQFHHENLVNL 66 Query: 436 IGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRD 494 I + + + LV E + L++ ++ K + + + Q+ + YL +N +HRD Sbjct: 67 IEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNIIHRD 126 Query: 495 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE-CINYYKFSSKS 553 + N+L+ K+ DFG ++ L A + Y + +W + APE + + Sbjct: 127 IKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRW---YRAPELVLKDTSYGKPV 183 Query: 554 DVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLE--------------------KGERMGC 593 D+W+ G ++ E + G ++ + G + Sbjct: 184 DIWALGCMIIEMAT-GNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQ 242 Query: 594 ---PAG----CPR---EMYDLMNLCWTYDVENRPGFAAVELRLRNYYY 631 P P+ + D+++ C D +R + + L + Y+ Sbjct: 243 VQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDL---LHHEYF 287 >1U5R-A nrPDB Length = 348 Score = 212 bits (539), Expect = 5e-55, Method: Composition-based stats. Identities = 63/293 (21%), Positives = 113/293 (38%), Gaps = 19/293 (6%) Query: 339 EALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKT 398 + +P D E+ K+ D + L + +E+G G+FG V + + Sbjct: 27 DPMPAGGRAGSLKDPDVAELFFKD---DPEKLFSDLREIGHGSFGAVYFARDV--RNSEV 81 Query: 399 VAVKILKNEANDPALK-DELLAEANVMQQLDNPYIVRMIGICEAESW-MLVMEMAELGPL 456 VA+K + K +++ E +Q+L +P ++ G E LVME Sbjct: 82 VAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSAS 141 Query: 457 NKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLS 516 + + +++ I + H G+ YL N +HRD+ A N+LL K+ DFG + Sbjct: 142 DLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSA 201 Query: 517 KALRADENYYKAQTHGKWPVKWYAPECIN---YYKFSSKSDVWSFGVLMWEAFSYGQKPY 573 + ++ W APE I ++ K DVWS G+ E + + P Sbjct: 202 SIMAPANSFV-------GTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIE-LAERKPPL 253 Query: 574 RGMKGSEVTAMLEKGERMGCPAGCPRE-MYDLMNLCWTYDVENRPGFAAVELR 625 M + + E +G E + ++ C ++RP + Sbjct: 254 FNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKH 306 >2VD5-A nrPDB Length = 412 Score = 211 bits (537), Expect = 9e-55, Method: Composition-based stats. Identities = 68/281 (24%), Positives = 114/281 (40%), Gaps = 21/281 (7%) Query: 352 YADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEAND 410 +A+P +R KEV L R + K +G G F V +MK+ + A+KI+ K + Sbjct: 45 WAEPIVVRLKEVRLQRDDFEIL-KVIGRGAFSEV--AVVKMKQTGQVYAMKIMNKWDMLK 101 Query: 411 PALKDELLAEANVMQQLDNPYIVRMIGICEAESW-MLVMEMAELGPLNKYLQQ-NRHVKD 468 E +V+ D +I ++ + E++ LVME G L L + + Sbjct: 102 RGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPA 161 Query: 469 KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKA 528 + + ++ M + + +VHRD+ N+LL + +++DFG LRAD Sbjct: 162 EMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSL 221 Query: 529 QTHGKWPVKWYAPECIN-------YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 + +PE + + + D W+ GV +E F YGQ P+ +E Sbjct: 222 --VAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMF-YGQTPFYADSTAET 278 Query: 582 TAMLEK-GERMGCP---AGCPREMYDLMNLCWTYDVENRPG 618 + E + P G P E D + E R G Sbjct: 279 YGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCP-PETRLG 318 >2GCD-A nrPDB Length = 309 Score = 211 bits (536), Expect = 1e-54, Method: Composition-based stats. Identities = 59/266 (22%), Positives = 105/266 (39%), Gaps = 16/266 (6%) Query: 366 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALK-DELLAEANVM 424 D + L + +E+G G+FG V + + VA+K + K +++ E + Sbjct: 12 DPEKLFSDLREIGHGSFGAVYFARDV--RNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFL 69 Query: 425 QQLDNPYIVRMIGICEAESW-MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMK 483 Q+L +P ++ G E LVME + + +++ I + H G+ Sbjct: 70 QKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLA 129 Query: 484 YLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPEC 543 YL N +HRD+ A N+LL K+ DFG + + ++ W APE Sbjct: 130 YLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFV-------GTPYWMAPEV 182 Query: 544 IN---YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600 I ++ K DVWS G+ E + + P M + + E +G E Sbjct: 183 ILAMDEGQYDGKVDVWSLGITCIE-LAERKPPLFNMNAMSALYHIAQNESPALQSGHWSE 241 Query: 601 -MYDLMNLCWTYDVENRPGFAAVELR 625 + ++ C ++RP + Sbjct: 242 YFRNFVDSCLQKIPQDRPTSEVLLKH 267 >6DTL-A nrPDB Length = 364 Score = 211 bits (536), Expect = 1e-54, Method: Composition-based stats. Identities = 58/297 (19%), Positives = 115/297 (38%), Gaps = 45/297 (15%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 +G G +G V + ++VA+K + N ++ L E +++ +D+ IV + Sbjct: 37 PIGKGAYGIVCSAMN--SETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 94 Query: 436 IGICEAE------SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 I + E+ + L++ ++ N+ + +++ ++Q+ G+KY+ +N Sbjct: 95 RDIIPPPLRNAFNDVYIAYELMDT-DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSAN 153 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE-CINYYK 548 +HRDL N+LL KI DFGL++ + ++ ++ +W + APE +N Sbjct: 154 VLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTEYVVTRW---YRAPELLLNSSD 209 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMK--------------------------GSEVT 582 +++ DVWS G + E + + G Sbjct: 210 YTAAIDVWSVGCIFMELMDR-KPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYI 268 Query: 583 AMLEKGERMGCPAGCP---REMYDLMNLCWTYDVENRPGF-AAVELRLRNYYYDVVN 635 L R P DL+ T+D R A+ N +D+ + Sbjct: 269 RQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISD 325 >3LM0-A nrPDB Length = 327 Score = 210 bits (535), Expect = 2e-54, Method: Composition-based stats. Identities = 60/277 (21%), Positives = 114/277 (41%), Gaps = 24/277 (8%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDN-P 430 L KELG G F V++ K + A K LK + E+L E V++ + P Sbjct: 32 LTSKELGRGKFAVVRQCI--SKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCP 89 Query: 431 YIVRMIGICE-AESWMLVMEMAELGPLNKYL--QQNRHVKDKNIIELVHQVSMGMKYLEE 487 ++ + + E +L++E A G + + V + ++I L+ Q+ G+ YL + Sbjct: 90 RVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQ 149 Query: 488 SNFVHRDLAARNVLLVT---QHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 +N VH DL +N+LL + KI DFG+S+ + + ++ APE + Sbjct: 150 NNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKI----GHACELREIMGTPEYLAPEIL 205 Query: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGER---MGCPAGCPREM 601 NY ++ +D+W+ G++ + ++ P+ G E + + + + Sbjct: 206 NYDPITTATDMWNIGIIAYMLLTH-TSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLA 264 Query: 602 YDLMNLCWTYDVENRPGFAAVELR-------LRNYYY 631 D + + E RP N ++ Sbjct: 265 TDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFH 301 >4BGQ-A nrPDB Length = 304 Score = 210 bits (535), Expect = 2e-54, Method: Composition-based stats. Identities = 61/287 (21%), Positives = 106/287 (36%), Gaps = 48/287 (16%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 +G G +G V K + K+ + VA+K K+ + +K+ L E +++ L IV + Sbjct: 19 VVGEGAYGVVLKCRH--KETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVEL 76 Query: 436 IGICEAES-WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRD 494 LV E E L + V + + ++Q+ + + +++ VHRD Sbjct: 77 KEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRD 136 Query: 495 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECINYYKFSSKS 553 + N+L+ K+ DFG ++ L N A + +WY +PE + + Sbjct: 137 IKPENLLISHNDVLKLCDFGFARNLSEGNN---ANYDEEVATRWYRSPELLLGAPYGKSV 193 Query: 554 DVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK--------------------GERMGC 593 D+WS G ++ E S GQ + G + ++K G R Sbjct: 194 DMWSVGCILGE-LSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPA 252 Query: 594 ---PAGCPRE--------MYDLMNLCWTYDVENR---------PGFA 620 P R + DLM D +R P F Sbjct: 253 VNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQ 299 >5UUU-A nrPDB Length = 547 Score = 210 bits (534), Expect = 2e-54, Method: Composition-based stats. Identities = 56/272 (20%), Positives = 110/272 (40%), Gaps = 18/272 (6%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDEL-LAEANVMQQL---DN 429 + +G G FG V K A+K L + + L L E ++ + D Sbjct: 203 HRIIGRGGFGEVYGCRKA--DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDC 260 Query: 430 PYIVRM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 P+IV M + ++++ G L+ +L Q+ + ++ ++ +G++++ Sbjct: 261 PFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNR 320 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY- 547 V+RDL N+LL + +ISD GL+ + + THG + APE + Sbjct: 321 FVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----YMAPEVLQKGV 375 Query: 548 KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERM--GCPAGCPREMYDLM 605 + S +D +S G ++++ G P+R K + + M P E+ L+ Sbjct: 376 AYDSSADWFSLGCMLFKLL-RGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 434 Query: 606 NLCWTYDVENRPGF--AAVELRLRNYYYDVVN 635 DV R G + + ++ ++ Sbjct: 435 EGLLQRDVNRRLGCLGRGAQEVKESPFFRSLD 466 >5NGU-A nrPDB Length = 381 Score = 210 bits (534), Expect = 2e-54, Method: Composition-based stats. Identities = 63/299 (21%), Positives = 118/299 (39%), Gaps = 45/299 (15%) Query: 355 PEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALK 414 PE +R + + + L +G G +G V Y + KV VA+K + Sbjct: 30 PEMVRGQVFDVGPRYTNLSY--IGEGAYGMVCSAYDNLNKVR--VAIKKISP-FEHQTYC 84 Query: 415 DELLAEANVMQQLDNPYIVRMIGICEAES------WMLVMEMAELGPLNKYLQQNRHVKD 468 L E ++ + + I+ + I A + +V ++ E L K L + +H+ + Sbjct: 85 QRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMET-DLYKLL-KTQHLSN 142 Query: 469 KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKA 528 +I ++Q+ G+KY+ +N +HRDL N+LL T KI DFGL++ D ++ Sbjct: 143 DHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGF 202 Query: 529 QTHGKWPVKWYAPEC-INYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSE------- 580 T + APE +N ++ D+WS G ++ E S + + G + Sbjct: 203 LTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN-RPIFPGKHYLDQLNHILG 261 Query: 581 ------------VTAMLEKGERMGCP-----------AGCPREMYDLMNLCWTYDVENR 616 + + + + P + DL++ T++ R Sbjct: 262 ILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKR 320 >3PVW-A nrPDB Length = 695 Score = 210 bits (534), Expect = 2e-54, Method: Composition-based stats. Identities = 56/272 (20%), Positives = 110/272 (40%), Gaps = 18/272 (6%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDEL-LAEANVMQQL---DN 429 + +G G FG V K A+K L + + L L E ++ + D Sbjct: 194 HRIIGRGGFGEVYGCRKA--DTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDC 251 Query: 430 PYIVRM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 P+IV M + ++++ G L+ +L Q+ + ++ ++ +G++++ Sbjct: 252 PFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNR 311 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY- 547 V+RDL N+LL + +ISD GL+ + + THG + APE + Sbjct: 312 FVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----YMAPEVLQKGV 366 Query: 548 KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERM--GCPAGCPREMYDLM 605 + S +D +S G ++++ G P+R K + + M P E+ L+ Sbjct: 367 AYDSSADWFSLGCMLFKLL-RGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLL 425 Query: 606 NLCWTYDVENRPGF--AAVELRLRNYYYDVVN 635 DV R G + + ++ ++ Sbjct: 426 EGLLQRDVNRRLGCLGRGAQEVKESPFFRSLD 457 >3VHK-A nrPDB Length = 368 Score = 209 bits (531), Expect = 4e-54, Method: Composition-based stats. Identities = 73/194 (37%), Positives = 102/194 (52%), Gaps = 7/194 (3%) Query: 437 GICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLA 496 G E +S V E L K + +++I QV+ GM++L +HRDLA Sbjct: 173 GFVEEKSLSDVEEEEAPEDLYK-----DFLTLEHLICYSFQVAKGMEFLASRKCIHRDLA 227 Query: 497 ARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVW 556 ARN+LL ++ KI DFGL++ + D +Y + + P+KW APE I ++ +SDVW Sbjct: 228 ARNILLSEKNVVKICDFGLARDIYKDPDYVRKG-DARLPLKWMAPETIFDRVYTIQSDVW 286 Query: 557 SFGVLMWEAFSYGQKPYRGMK-GSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVEN 615 SFGVL+WE FS G PY G+K E L++G RM P EMY M CW + Sbjct: 287 SFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQ 346 Query: 616 RPGFAAVELRLRNY 629 RP F+ + L N Sbjct: 347 RPTFSELVEHLGNL 360 Score = 90.8 bits (224), Expect = 1e-18, Method: Composition-based stats. Identities = 36/133 (27%), Positives = 59/133 (44%), Gaps = 14/133 (10%) Query: 339 EALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYY---QMKKV 395 + LP+D PY + P R L L K LG G FG V + Sbjct: 6 DELPLDEHCERLPYDASKWEFP------RDRLKL-GKPLGRGAFGQVIEADAFGIDKTAT 58 Query: 396 VKTVAVKILKNEANDPALKDELLAEANVMQQLDNP-YIVRMIGICEAE--SWMLVMEMAE 452 +TVAVK+LK A + L++E ++ + + +V ++G C M+++E + Sbjct: 59 CRTVAVKMLKEGATHSEHR-ALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCK 117 Query: 453 LGPLNKYLQQNRH 465 G L+ YL+ R+ Sbjct: 118 FGNLSTYLRSKRN 130 >4QTB-A nrPDB Length = 380 Score = 208 bits (529), Expect = 6e-54, Method: Composition-based stats. Identities = 56/282 (19%), Positives = 110/282 (39%), Gaps = 43/282 (15%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G G +G V Y ++K VA+K + L E ++ + + ++ + Sbjct: 49 IGEGAYGMVSSAYDHVRKTR--VAIKKISP-FEHQTYCQRTLREIQILLRFRHENVIGIR 105 Query: 437 GICEAESW------MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 I A + +V ++ E L K L+ + + + +I ++Q+ G+KY+ +N Sbjct: 106 DILRASTLEAMRDVYIVQDLMET-DLYKLLKSQQ-LSNDHICYFLYQILRGLKYIHSANV 163 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPEC-INYYKF 549 +HRDL N+L+ T KI DFGL++ + ++ T + APE +N + Sbjct: 164 LHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGY 223 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSE-------------------VTAMLEKGER 590 + D+WS G ++ E S + + G + + M + Sbjct: 224 TKSIDIWSVGCILAEMLSN-RPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYL 282 Query: 591 MGCPAG--------CPRE---MYDLMNLCWTYDVENRPGFAA 621 P+ P+ DL++ T++ R Sbjct: 283 QSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEE 324 >3ORP-A nrPDB Length = 311 Score = 208 bits (529), Expect = 6e-54, Method: Composition-based stats. Identities = 58/260 (22%), Positives = 109/260 (41%), Gaps = 15/260 (5%) Query: 366 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNE-ANDPALKDELLAEANVM 424 DR L + LG G V + VAVK+L+ + A DP+ EA Sbjct: 12 DRYEL---GEILGFGGMSEVHLARDLRDH--RDVAVKVLRADLARDPSFYLRFRREAQNA 66 Query: 425 QQLDNPYIVRMIGICEAESW-----MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVS 479 L++P IV + EAE+ +VME + L + + K IE++ Sbjct: 67 AALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADAC 126 Query: 480 MGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY 539 + + ++ +HRD+ N+++ + K+ DFG+++A+ N ++ Sbjct: 127 QALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYL 186 Query: 540 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPA---G 596 +PE ++SDV+S G +++E + G+ P+ G V + + + A G Sbjct: 187 SPEQARGDSVDARSDVYSLGCVLYEVLT-GEPPFTGDSPVSVAYQHVREDPIPPSARHEG 245 Query: 597 CPREMYDLMNLCWTYDVENR 616 ++ ++ + ENR Sbjct: 246 LSADLDAVVLKALAKNPENR 265 >4TNB-A nrPDB Length = 590 Score = 207 bits (528), Expect = 9e-54, Method: Composition-based stats. Identities = 62/271 (22%), Positives = 117/271 (43%), Gaps = 18/271 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDEL-LAEANVMQQLDNPYIV 433 + LG G FG V Q++ K A K L+ + + + L E +++++++ ++V Sbjct: 190 RVLGKGGFGEVCAC--QVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVV 247 Query: 434 RMIGICEA-ESWMLVMEMAELGPLNKYL--QQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 + E ++ LV+ + G L ++ N +++ + ++ G++ L N Sbjct: 248 NLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHENT 307 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 V+RDL N+LL + +ISD GL+ + + V + APE +N ++ Sbjct: 308 VYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR----GRVGTVGYMAPEVLNNQRYG 363 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGS----EVTAMLEKGERMGCPAGCPREMYDLMN 606 D W G L++E GQ P+RG K EV + + E + E + Sbjct: 364 LSPDYWGLGCLIYEMI-EGQSPFRGRKEKVKREEVDRRVLETEEV-YSHKFSEEAKSICK 421 Query: 607 LCWTYDVENRPGFAAVE--LRLRNYYYDVVN 635 + T D + R G E R+ ++ +N Sbjct: 422 MLLTKDAKQRLGCQEEEAAEVKRHPFFRNMN 452 >4EWQ-A nrPDB Length = 383 Score = 207 bits (528), Expect = 9e-54, Method: Composition-based stats. Identities = 49/221 (22%), Positives = 98/221 (44%), Gaps = 21/221 (9%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 +GSG +G+V + K VAVK L E +++ + + ++ + Sbjct: 52 PVGSGAYGSVCAAFD--TKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGL 109 Query: 436 IGIC-------EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 + + E LV + LN + + + + D ++ L++Q+ G+KY+ + Sbjct: 110 LDVFTPARSLEEFNDVYLVTHLM-GADLNN-IVKCQKLTDDHVQFLIYQILRGLKYIHSA 167 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APEC-INY 546 + +HRDL N+ + KI DFGL++ + + G +WY APE +N+ Sbjct: 168 DIIHRDLKPSNLAVNEDCELKILDFGLAR-------HTDDEMTGYVATRWYRAPEIMLNW 220 Query: 547 YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 ++ D+WS G +M E + G+ + G + ++ + Sbjct: 221 MHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILR 260 >2BRG-A nrPDB Length = 297 Score = 207 bits (527), Expect = 1e-53, Method: Composition-based stats. Identities = 54/253 (21%), Positives = 102/253 (40%), Gaps = 9/253 (3%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 + LG G +G V+ ++ + VAVKI+ + + + E + + L++ +V+ Sbjct: 13 QTLGEGAYGEVQLAVNRV--TEEAVAVKIVDMK-RAVDCPENIKKEICINKMLNHENVVK 69 Query: 435 MIGICEAESW-MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 G + L +E G L ++ + + + + HQ+ G+ YL HR Sbjct: 70 FYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHR 129 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS-SK 552 D+ N+LL + KISDFGL+ R + + + APE + +F Sbjct: 130 DIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCG-TLPYVAPELLKRREFHAEP 188 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGS--EVTAMLEKGERMGCPAGCPREMYDLMNLCWT 610 DVWS G+++ + G+ P+ S E + EK + L++ Sbjct: 189 VDVWSCGIVLTAMLA-GELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILV 247 Query: 611 YDVENRPGFAAVE 623 + R ++ Sbjct: 248 ENPSARITIPDIK 260 >3HKO-A nrPDB Length = 345 Score = 207 bits (526), Expect = 1e-53, Method: Composition-based stats. Identities = 68/306 (22%), Positives = 116/306 (37%), Gaps = 59/306 (19%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKIL---KNEANDPALKDELLAEANVMQQLDNPYIV 433 +G G++G V+ + ++ A+KI+ K +P + + E +M++L +P I Sbjct: 34 IGQGSYGVVRVAIENQTRAIR--AIKIMNKNKIRQINPKDVERIKTEVRLMKKLHHPNIA 91 Query: 434 RMIGICEAESW-MLVMEMAELGPLNKYL-------------------------------- 460 R+ + E E + LVME+ G L L Sbjct: 92 RLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECNEEAIN 151 Query: 461 ------QQNRHV--KDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQ--HYAKI 510 +++ ++K I ++ Q+ + YL HRD+ N L T K+ Sbjct: 152 GSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKSFEIKL 211 Query: 511 SDFGLSKALR--ADENYYKAQTHGKWPVKWYAPECIN--YYKFSSKSDVWSFGVLMWEAF 566 DFGLSK + YY T P + APE +N + K D WS GVL+ Sbjct: 212 VDFGLSKEFYKLNNGEYYGMTTKAGTPY-FVAPEVLNTTNESYGPKCDAWSAGVLL-HLL 269 Query: 567 SYGQKPYRGMKGSEVTAML-EKGERMGCPAG--CPREMYDLMNLCWTYDVENRPGFAAVE 623 G P+ G+ ++ + + K P DL++ +V+ R F A+ Sbjct: 270 LMGAVPFPGVNDADTISQVLNKKLCFENPNYNVLSPLARDLLSNLLNRNVDER--FDAMR 327 Query: 624 LRLRNY 629 + Sbjct: 328 ALQHPW 333 >5UIU-A nrPDB Length = 323 Score = 207 bits (526), Expect = 2e-53, Method: Composition-based stats. Identities = 67/293 (22%), Positives = 118/293 (40%), Gaps = 27/293 (9%) Query: 357 EIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKIL--KNEANDPALK 414 E++ D + +++ ++G G FG V KGY TVAVK L + LK Sbjct: 35 ELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNT----TVAVKKLAAMVDITTEELK 90 Query: 415 DELLAEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYL---QQNRHVKDKN 470 + E VM + + +V ++G + + LV G L L + Sbjct: 91 QQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHM 150 Query: 471 IIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQT 530 ++ + G+ +L E++ +HRD+ + N+LL AKISDFGL++A Sbjct: 151 RCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTS- 209 Query: 531 HGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG-- 588 + APE + + KSD++SFGV++ E + G + ++ +++ Sbjct: 210 RIVGTTAYMAPEALRGE-ITPKSDIYSFGVVLLEIIT-GLPAVDEHREPQLLLDIKEEIE 267 Query: 589 -----------ERMGCPAGCPRE-MYDLMNLCWTYDVENRPGFAAVELRLRNY 629 ++M E MY + + C RP V+ L+ Sbjct: 268 DEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEM 320 >1CM8-A nrPDB Length = 367 Score = 206 bits (525), Expect = 2e-53, Method: Composition-based stats. Identities = 54/247 (21%), Positives = 102/247 (41%), Gaps = 29/247 (11%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 + +GSG +G V + VA+K L E +++ + + ++ Sbjct: 31 QPVGSGAYGAVCSAVDG--RTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIG 88 Query: 435 MIGICEAE-------SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 487 ++ + + + LVM L K L ++ + + I LV+Q+ G++Y+ Sbjct: 89 LLDVFTPDETLDDFTDFYLVMPFM-GTDLGK-LMKHEKLGEDRIQFLVYQMLKGLRYIHA 146 Query: 488 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECI-N 545 + +HRDL N+ + KI DFGL++ ++ G +WY APE I N Sbjct: 147 AGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE-------MTGYVVTRWYRAPEVILN 199 Query: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGC------PR 599 + +++ D+WS G +M E + G+ ++G + + K G P Sbjct: 200 WMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMK--VTGTPPAEFVQRLQSD 256 Query: 600 EMYDLMN 606 E + M Sbjct: 257 EAKNYMK 263 >5J5T-A nrPDB Length = 370 Score = 206 bits (525), Expect = 2e-53, Method: Composition-based stats. Identities = 50/259 (19%), Positives = 95/259 (36%), Gaps = 16/259 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 + +GSG +G V K + A+K++K E + + E +M+ +P IV Sbjct: 10 QRIGSGTYGDVYKARNV--NTGELAAIKVIKLEPGEDFAV--VQQEIIMMKDCKHPNIVA 65 Query: 435 MIG-ICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 G + + ME G L + + I + + G+ YL +HR Sbjct: 66 YFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHR 125 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI---NYYKFS 550 D+ N+LL + K++DFG+S + A + W APE ++ Sbjct: 126 DIKGANILLTDNGHVKLADFGVSAQITA---TIAKRKAFIGTPYWMAPEVAAVERKGGYN 182 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE----RMGCPAGCPREMYDLMN 606 D+W+ G+ E + Q P + ++ K ++ + + Sbjct: 183 QLCDLWAVGITAIE-LAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVK 241 Query: 607 LCWTYDVENRPGFAAVELR 625 + T + + RP + Sbjct: 242 MALTKNPKKRPTAEKLLQH 260 >3GC0-A nrPDB Length = 329 Score = 206 bits (523), Expect = 3e-53, Method: Composition-based stats. Identities = 59/255 (23%), Positives = 109/255 (42%), Gaps = 19/255 (7%) Query: 349 ESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEA 408 + P + P +DR +LG G +G V K + +TVA+K ++ E Sbjct: 17 QGPGSMSVSAAPSATSIDRYRRIT---KLGEGTYGEVYKAIDTV--TNETVAIKRIRLEH 71 Query: 409 NDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVK 467 + + + E +++++L + I+ + + + L+ E AE L KY+ +N V Sbjct: 72 EEEGVPGTAIREVSLLKELQHRNIIELKSVIHHNHRLHLIFEYAEN-DLKKYMDKNPDVS 130 Query: 468 DKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLL-----VTQHYAKISDFGLSKALRAD 522 + I ++Q+ G+ + +HRDL +N+LL KI DFGL++A Sbjct: 131 MRVIKSFLYQLINGVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIP 190 Query: 523 ENYYKAQTHGKWPVKWYAPECINY-YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 + TH + + PE + +S+ D+WS + E + G SE+ Sbjct: 191 IRQF---THEIITLWYRPPEILLGSRHYSTSVDIWSIACIWAEMLMK-TPLFPG--DSEI 244 Query: 582 TAMLEKGERMGCPAG 596 + + E +G P Sbjct: 245 DQLFKIFEVLGLPDD 259 >3NYO-A nrPDB Length = 576 Score = 206 bits (523), Expect = 4e-53, Method: Composition-based stats. Identities = 52/249 (20%), Positives = 101/249 (40%), Gaps = 14/249 (5%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDEL-LAEANVMQQLDNPYIV 433 + LG G FG V Q++ K A K L+ + + + L E +++++++ ++V Sbjct: 190 RVLGKGGFGEVCAC--QVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVV 247 Query: 434 RMIGICEA-ESWMLVMEMAELGPLNKYLQQNR--HVKDKNIIELVHQVSMGMKYLEESNF 490 + E ++ LV+ + G L ++ + + ++ G++ L Sbjct: 248 SLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERI 307 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 V+RDL N+LL + +ISD GL+ + + V + APE + +++ Sbjct: 308 VYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI----KGRVGTVGYMAPEVVKNERYT 363 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGS---EVTAMLEKGERMGCPAGCPREMYDLMNL 607 D W+ G L++E + GQ P++ K E L K + L + Sbjct: 364 FSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQ 422 Query: 608 CWTYDVENR 616 D R Sbjct: 423 LLCKDPAER 431 >3FXW-A nrPDB Length = 336 Score = 205 bits (522), Expect = 4e-53, Method: Composition-based stats. Identities = 56/272 (20%), Positives = 108/272 (39%), Gaps = 31/272 (11%) Query: 367 RKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQ 426 L + LG G G V + +++ + + A+K+L + P + E+ Sbjct: 27 TDDYQLSKQVLGLGVNGKVLECFHR--RTGQKCALKLL---YDSPKARQEVDHHWQASGG 81 Query: 427 LDNPYIVRMIGICE-----AESWMLVMEMAELGPLNKYLQQNRH--VKDKNIIELVHQVS 479 P+IV ++ + E +++ME E G L +Q+ ++ E++ + Sbjct: 82 ---PHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIG 138 Query: 480 MGMKYLEESNFVHRDLAARNVLLVT---QHYAKISDFGLSKALRADENYYKAQTHGKWPV 536 +++L N HRD+ N+L + K++DFG +K E A + Sbjct: 139 TAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAK-----ETTQNALQTPCYTP 193 Query: 537 KWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERM---GC 593 + APE + K+ D+WS GV+M+ G P+ G ++ +++ R+ G Sbjct: 194 YYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GFPPFYSNTGQAISPGMKRRIRLGQYGF 252 Query: 594 P----AGCPREMYDLMNLCWTYDVENRPGFAA 621 P + + L+ L D R Sbjct: 253 PNPEWSEVSEDAKQLIRLLLKTDPTERLTITQ 284 >1UA2-A nrPDB Length = 346 Score = 205 bits (522), Expect = 4e-53, Method: Composition-based stats. Identities = 57/224 (25%), Positives = 101/224 (45%), Gaps = 15/224 (6%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPA---LKDELLAEANVMQQLDNPYIV 433 LG G F TV K K + VA+K +K A + L E ++Q+L +P I+ Sbjct: 18 LGEGQFATVYKARD--KNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 Query: 434 RMIGICEAESWM-LVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 491 ++ +S + LV + E L ++ N + +I + G++YL + + Sbjct: 76 GLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK-FS 550 HRDL N+LL K++DFGL+K+ + Y Q +W + APE + + + Sbjct: 135 HRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFGARMYG 191 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP 594 D+W+ G ++ E + P+ S++ + E +G P Sbjct: 192 VGVDMWAVGCILAELLL--RVPFLPGD-SDLDQLTRIFETLGTP 232 >4IC8-A nrPDB Length = 442 Score = 205 bits (522), Expect = 5e-53, Method: Composition-based stats. Identities = 57/316 (18%), Positives = 122/316 (38%), Gaps = 44/316 (13%) Query: 357 EIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE 416 + R +V D + +G+G +G V ++ + VA+K + N + Sbjct: 43 KARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRL--TGQQVAIKKIPNAFDVVTNAKR 100 Query: 417 LLAEANVMQQLDNPYIVRMIGIC-------EAESWMLVMEMAELGPLNKYLQQNRHVKDK 469 L E +++ + I+ + I E +S +V+++ E L++ + ++ + + Sbjct: 101 TLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIHSSQPLTLE 159 Query: 470 NIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQ 529 ++ ++Q+ G+KY+ + +HRDL N+L+ KI DFG+++ L ++ Sbjct: 160 HVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYF 219 Query: 530 THGKWPVKWY-APE-CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLE- 586 +WY APE ++ ++++ D+WS G + E + Q + G ++ Sbjct: 220 MTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQL-FPGKNYVHQLQLIMM 278 Query: 587 ------------------KGERMGCPAGCP-----------REMYDLMNLCWTYDVENRP 617 + P P R+ L+ ++ R Sbjct: 279 VLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARI 338 Query: 618 GFAAVELR-LRNYYYD 632 AA Y+D Sbjct: 339 SAAAALRHPFLAKYHD 354 >5TOS-A nrPDB Length = 395 Score = 205 bits (522), Expect = 5e-53, Method: Composition-based stats. Identities = 75/294 (25%), Positives = 128/294 (43%), Gaps = 41/294 (13%) Query: 374 DKELGSGNFGTVKKGYYQMK-------KVVKTVAVKILKNEANDPALKDELLAEANVMQQ 426 D +G G FG V KG+ +AVK L E E L E N + Q Sbjct: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG--HREWLTEINYLGQ 127 Query: 427 LDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQN----RHVKDKNIIELVHQVSMG 481 L +P +V++IG C E E +LV E + G L +L + + + + + + G Sbjct: 128 LSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKG 187 Query: 482 MKYLEES--NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY 539 + +L ++RD+ A N+LL + AK+SDFGL++ + Y + T + Sbjct: 188 LAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS-TRVMGTYGYA 246 Query: 540 APECINYYKFSSKSDVWSFGVLMWEAFSYGQ-----------------KPYRGMKGSEVT 582 APE ++ +++SDV+SFGVL+ E S + +PY K +V Sbjct: 247 APEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSK-RKVL 305 Query: 583 AMLEKGERMGCPAGCPRE---MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDV 633 +++ R+ P E M + C +++ ++RP V L+ ++ Sbjct: 306 LIVD--NRLDT-QYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNL 356 >3HNG-A nrPDB Length = 360 Score = 205 bits (521), Expect = 5e-53, Method: Composition-based stats. Identities = 64/168 (38%), Positives = 97/168 (57%), Gaps = 2/168 (1%) Query: 463 NRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRAD 522 + +++I QV+ GM++L +HRDLAARN+LL + KI DFGL++ + + Sbjct: 193 KEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKN 252 Query: 523 ENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMK-GSEV 581 +Y + + P+KW APE I +S+KSDVWS+GVL+WE FS G PY G++ + Sbjct: 253 PDYVRKG-DTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDF 311 Query: 582 TAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNY 629 + L +G RM P E+Y +M CW D + RP FA + +L + Sbjct: 312 CSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDL 359 Score = 90.5 bits (223), Expect = 2e-18, Method: Composition-based stats. Identities = 35/134 (26%), Positives = 61/134 (45%), Gaps = 14/134 (10%) Query: 339 EALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYY---QMKKV 395 + +P+D + PY + R+ L L K LG G FG V + + Sbjct: 4 DEVPLDEQCERLPYDASKW------EFARERLKL-GKSLGRGAFGKVVQASAFGIKKSPT 56 Query: 396 VKTVAVKILKNEANDPALKDELLAEANVMQQLDNP-YIVRMIGICEAE--SWMLVMEMAE 452 +TVAVK+LK A K L+ E ++ + + +V ++G C + M+++E + Sbjct: 57 CRTVAVKMLKEGATASEYK-ALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCK 115 Query: 453 LGPLNKYLQQNRHV 466 G L+ YL+ R + Sbjct: 116 YGNLSNYLKSKRDL 129 >6CCF-A nrPDB Length = 290 Score = 204 bits (520), Expect = 7e-53, Method: Composition-based stats. Identities = 61/282 (21%), Positives = 121/282 (42%), Gaps = 40/282 (14%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPAL---------------------- 413 E+G G +G V+ Y + + + A+K+L + Sbjct: 12 EIGKGAYGVVRLAYNESED--RHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGPAKQL 69 Query: 414 --KDELLAEANVMQQLDNPYIVRMIGICEA---ESWMLVMEMAELGPLNKYLQQNRHVKD 468 + + E ++++LD+ +V++I + + ++ LV ++ GP+ + + ++ + Sbjct: 70 LPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME-VPCDKPFSE 128 Query: 469 KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKA 528 + + V +G++YL VHRD+ N+LL + KI+DFG+S ++ + Sbjct: 129 EQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSS 188 Query: 529 QTHGKWPVKWYAPECI--NYYKFSSKS-DVWSFGVLMWEAFSYGQKPYRGMKGSEVTAML 585 + APE I + FS K+ DVW+ GV ++ F YG+ P+ + + Sbjct: 189 ---TAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLY-CFVYGKCPFIDDFILALHRKI 244 Query: 586 EKGERMGCP--AGCPREMYDLMNLCWTYDVENRPGFAAVELR 625 K E + P E+ DL+ + E R G ++L Sbjct: 245 -KNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLH 285 >3OZ6-A nrPDB Length = 388 Score = 204 bits (520), Expect = 7e-53, Method: Composition-based stats. Identities = 58/282 (20%), Positives = 112/282 (39%), Gaps = 37/282 (13%) Query: 365 LDRKLLTLED--KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEAN 422 +DR +L + K+LG G +G V K + + + VAVK + + + E Sbjct: 3 VDRHVLRKYELVKKLGKGAYGIVWKSIDR--RTGEVVAVKKIFDAFQNSTDAQRTFREIM 60 Query: 423 VMQQLD-NPYIVRMIGICEAES---WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQV 478 ++ +L + IV ++ + A++ LV + E L+ ++ N ++ + +V+Q+ Sbjct: 61 ILTELSGHENIVNLLNVLRADNDRDVYLVFDYMET-DLHAVIRAN-ILEPVHKQYVVYQL 118 Query: 479 SMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL------------------R 520 +KYL +HRD+ N+LL + + K++DFGLS++ Sbjct: 119 IKVIKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTE 178 Query: 521 ADENYYKAQTHGKWPVKWYAPECINY-YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGS 579 ++ T + APE + K++ D+WS G ++ E G+ + G Sbjct: 179 NFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILC-GKPIFPGSSTM 237 Query: 580 EVTAMLEKGERMGCPAG-----CPREMYDLMNLCWTYDVENR 616 + + P+ M VE R Sbjct: 238 NQLERI--IGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIR 277 >4EQM-A nrPDB Length = 294 Score = 204 bits (520), Expect = 8e-53, Method: Composition-based stats. Identities = 58/260 (22%), Positives = 109/260 (41%), Gaps = 13/260 (5%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVK-ILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 +LG G TV + + VA+K I E + QL + IV Sbjct: 18 KLGGGGMSTVYLAEDTILNI--KVAIKAIFIPPREKEETLKRFEREVHNSSQLSHQNIVS 75 Query: 435 MIGI-CEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 MI + E + + LVME E L++Y++ + + I +Q+ G+K+ + VHR Sbjct: 76 MIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVDTAINFTNQILDGIKHAHDMRIVHR 135 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKS 553 D+ +N+L+ + KI DFG++KAL E H V++++PE + Sbjct: 136 DIKPQNILIDSNKTLKIFDFGIAKAL--SETSLTQTNHVLGTVQYFSPEQAKGEATDECT 193 Query: 554 DVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERM----GCPAGCPREMYDLMNLCW 609 D++S G++++E G+ P+ G + + P+ + +++ Sbjct: 194 DIYSIGIVLYEML-VGEPPFNGETAVSIAIKHIQDSVPNVTTDVRKDIPQSLSNVILRAT 252 Query: 610 TYDVENRPGFAAVELRLRNY 629 D NR + ++ + Sbjct: 253 EKDKANR--YKTIQEMKDDL 270 >4ZSG-A nrPDB Length = 347 Score = 204 bits (519), Expect = 1e-52, Method: Composition-based stats. Identities = 54/298 (18%), Positives = 117/298 (39%), Gaps = 44/298 (14%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 + +G+G +G V ++ + VA+K + N + L E +++ + I+ Sbjct: 13 ETIGNGAYGVVSSARRRL--TGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIA 70 Query: 435 MIGIC-------EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 487 + I E +S +V+++ E L++ + ++ + +++ ++Q+ G+KY+ Sbjct: 71 IKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHS 129 Query: 488 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APE-CIN 545 + +HRDL N+L+ KI DFG+++ L ++ +WY APE ++ Sbjct: 130 AQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLS 189 Query: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLE------------------- 586 ++++ D+WS G + E + Q + G ++ Sbjct: 190 LHEYTQAIDLWSVGCIFGEMLARRQL-FPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERV 248 Query: 587 KGERMGCPAGCP-----------REMYDLMNLCWTYDVENRPGFAAVELR-LRNYYYD 632 + P P R+ L+ ++ R AA Y+D Sbjct: 249 RAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHD 306 >6CQF-A nrPDB Length = 297 Score = 204 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 55/276 (19%), Positives = 101/276 (36%), Gaps = 16/276 (5%) Query: 358 IRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDEL 417 + P D + + LG G +G V K ++ VA+K++K E +D L Sbjct: 5 VDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVS--GDLVALKMVKMEPDD--DVSTL 60 Query: 418 LAEANVMQQLDNPYIVRMIGICE-AESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVH 476 E +++ + IV G + + ME G L Q + + I + Sbjct: 61 QKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCR 120 Query: 477 QVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPV 536 +V G+ YL +HRD+ N+L+ +++DFG+S + + Sbjct: 121 EVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQI---GATLARRLAFIGTP 177 Query: 537 KWYAPE---CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK-GERMG 592 W APE ++ D+WS G+ E + Q P + V ++ K G + Sbjct: 178 YWMAPEVAAVALKGGYNELCDIWSLGITAIE-LAELQPPLFDVHPLRVLFLMTKSGYQPP 236 Query: 593 C---PAGCPREMYDLMNLCWTYDVENRPGFAAVELR 625 ++ + + T + RP + Sbjct: 237 RLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSH 272 >2WTK-C nrPDB Length = 305 Score = 204 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 57/261 (21%), Positives = 106/261 (40%), Gaps = 13/261 (4%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 LG G++G VK+ + V + K P + + E ++++L + +++++ Sbjct: 13 LGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLV 72 Query: 437 GIC---EAESWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGMKYLEESNFV 491 + E + +VME G + + L + Q+ G++YL V Sbjct: 73 DVLYNEEKQKMYMVMEYCVCG-MQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIV 131 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF-- 549 H+D+ N+LL T KIS G+++AL +T P + PE N Sbjct: 132 HKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPA-FQPPEIANGLDTFS 190 Query: 550 SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCW 609 K D+WS GV ++ + G P+ G ++ + KG P C + DL+ Sbjct: 191 GFKVDIWSAGVTLYNI-TTGLYPFEGDNIYKLFENIGKGS-YAIPGDCGPPLSDLLKGML 248 Query: 610 TYDVENRPGFAAVELRLRNYY 630 Y+ R + R +++ Sbjct: 249 EYEPAKRFSIRQI--RQHSWF 267 >4MYG-A nrPDB Length = 372 Score = 204 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 61/295 (20%), Positives = 111/295 (37%), Gaps = 55/295 (18%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +GSG +G+V K+ + VA+K L E +++ + + ++ ++ Sbjct: 51 VGSGAYGSVCSAID--KRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLL 108 Query: 437 GICEAES-------WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 + S + LVM + L K + ++ I LV+Q+ G+KY+ + Sbjct: 109 DVFTPASSLRNFYDFYLVMPFMQT-DLQKIM--GMEFSEEKIQYLVYQMLKGLKYIHSAG 165 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECINY-Y 547 VHRDL N+ + KI DFGL++ + A+ G +WY APE I Sbjct: 166 VVHRDLKPGNLAVNEDCELKILDFGLAR-------HADAEMTGYVVTRWYRAPEVILSWM 218 Query: 548 KFSSKSDVWSFGVLMWEAFSYGQKPYRGMK-------------------GSEVTAMLEKG 588 ++ D+WS G +M E + G+ ++G ++ K Sbjct: 219 HYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKS 277 Query: 589 ERMGCP-----------AGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYD 632 P + DL+ DV+ R A L + +++ Sbjct: 278 YIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQ---ALTHPFFE 329 >2W96-B nrPDB Length = 306 Score = 202 bits (515), Expect = 3e-52, Method: Composition-based stats. Identities = 59/286 (20%), Positives = 114/286 (39%), Gaps = 46/286 (16%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLD---NPYI 432 E+G G +GTV K VA+K ++ + L + E ++++L+ +P + Sbjct: 11 EIGVGAYGTVYKARD--PHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFEHPNV 68 Query: 433 VRMIGICEAE------SWMLVMEMAELGPLNKYLQQNRH--VKDKNIIELVHQVSMGMKY 484 VR++ +C LV E + L YL + + + I +L+ Q G+ + Sbjct: 69 VRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 127 Query: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 L + VHRDL N+L+ + K++DFGL++ +Y A + + APE + Sbjct: 128 LHANCIVHRDLKPENILVTSGGTVKLADFGLARIY----SYQMALDPVVVTLWYRAPEVL 183 Query: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREM--- 601 +++ D+WS G + E F + + G ++ + + PR++ Sbjct: 184 LQSTYATPVDMWSVGCIFAEMFRR-KPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLP 242 Query: 602 -----------------------YDLMNLCWTYDVENRPG-FAAVE 623 L+ T++ R F A++ Sbjct: 243 RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ 288 >4LQP-A nrPDB Length = 508 Score = 202 bits (515), Expect = 3e-52, Method: Composition-based stats. Identities = 65/325 (20%), Positives = 114/325 (35%), Gaps = 68/325 (20%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKIL-KNEANDPALKDELLAEANVMQQLDNPYIV 433 K +G G FG V+ Q K K A+K L K+E + AE +V+ D+P++V Sbjct: 108 KVIGKGAFGEVRL--VQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSPWVV 165 Query: 434 RMIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 + + + L+ME G L L + + + + + + ++ + + F+H Sbjct: 166 SLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKLGFIH 225 Query: 493 RDLAARNVLLVTQHYAKISDFGLS-------------KALRADENYYKAQTHGK------ 533 R + N+L+ + + K+SDFGLS K L+ DE G Sbjct: 226 RAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGISKPGTYNANTT 285 Query: 534 ---------------------------------------WPVKWYAPECINYYKFSSKSD 554 + APE Y + + D Sbjct: 286 DTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYIAPEIFLYQGYGQECD 345 Query: 555 VWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGER-MGCPAG--CPREMYDLMNLCWTY 611 WS G +M+E G P+ E + E+ + P E DL+ T+ Sbjct: 346 WWSLGAIMYECL-IGWPPFCSETPQETYRKIMNFEQTLQFPDDIHISYEAEDLIRRLLTH 404 Query: 612 DVENRPG-FAAVELRLRNYYYDVVN 635 + R G + + ++ V+ Sbjct: 405 -ADQRLGRHGGADEIKSHPFFRGVD 428 >4QNY-A nrPDB Length = 354 Score = 202 bits (514), Expect = 4e-52, Method: Composition-based stats. Identities = 60/306 (19%), Positives = 120/306 (39%), Gaps = 52/306 (16%) Query: 366 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNE-ANDPALKDELLAEANVM 424 DR LL ++ +G+G++G V + K + VA+K + E + L +L E ++ Sbjct: 20 DRYLL---ERIIGAGSYGVVIRARDT-KSDNRLVAMKRVNKEIFEEVILAKRILREIKLL 75 Query: 425 QQLDNPYIVRMIGICEA------ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQV 478 ++ I+ + I + + +VM++ E L + L+ + + + +I ++Q Sbjct: 76 AHFNDDNIIGLRNILTPEDPENFDHFYIVMDIMET-DLKQVLRSGQELTEAHIQFFIYQA 134 Query: 479 SMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKW 538 + + + +HRD+ N+L+ T KI DFGL+K Y +W + Sbjct: 135 LRALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRW---Y 191 Query: 539 YAPE-CINYYKFSSKSDVWSFGVLMWEAFSYGQKP-YRGMKGSEVTAML----------- 585 APE + +S++ DVW G ++ E G +P ++G + Sbjct: 192 RAPELVMEDKDYSAQIDVWGIGCILGELL--GSRPLFQGKDRVNQLDKIVDVIGTPSEED 249 Query: 586 --------------EKGERMGCP-----AGCPREMYDLMNLCWTYDVENRPGFAAVELRL 626 +K R E DL+ ++ + R V + Sbjct: 250 INSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRIT---VLQAM 306 Query: 627 RNYYYD 632 R+ + + Sbjct: 307 RHPFLE 312 >4BTF-A nrPDB Length = 469 Score = 201 bits (512), Expect = 6e-52, Method: Composition-based stats. Identities = 61/284 (21%), Positives = 135/284 (47%), Gaps = 18/284 (6%) Query: 355 PEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDP--A 412 P++++ KE + ++ L +L + T+ +G Y V +K+ N + Sbjct: 183 PQDLQIKE--IPKEHLGPPWTKLKTSKMSTIYRGEYHRSPVT----IKVFNNPQAESVGI 236 Query: 413 LKDELLAEANVMQQLDNPYIVRMIGICEAES-----WMLVMEMAELGPLNKYLQQNRHVK 467 ++ E M++ D+P I+R+ GIC ++ + +VME ELG L + L + + + Sbjct: 237 VRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLT 296 Query: 468 DKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYK 527 LV + + G+ L S +HR++++ + L+ + K++ F LSK + K Sbjct: 297 MSVRSLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAK 356 Query: 528 AQTHGK-WPVKWYAPECIN--YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAM 584 + + + +PE + + + K++++SFG+++WE + G+ P+ G ++ + Sbjct: 357 STKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIAT-GKIPFEGCDSKKIREL 415 Query: 585 LEKGERM-GCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 + + ++ CP + +++N C ++ RP + RL Sbjct: 416 VAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGILERLS 459 >3VN9-A nrPDB Length = 340 Score = 201 bits (512), Expect = 6e-52, Method: Composition-based stats. Identities = 60/262 (22%), Positives = 111/262 (42%), Gaps = 20/262 (7%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 ELG G +G V+K + + +AVK ++ N K L+ M+ +D P+ V Sbjct: 58 ELGRGAYGVVEKMRHVPS--GQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTF 115 Query: 436 IGI-CEAESWMLVMEMAELGPLNKY----LQQNRHVKDKNIIELVHQVSMGMKYLEES-N 489 G + ME+ + L+K+ + + + + + + ++ + +++L + Sbjct: 116 YGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 174 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI----N 545 +HRD+ NVL+ K+ DFG+S L A+T + APE I N Sbjct: 175 VIHRDVKPSNVLINALGQVKMCDFGISGYLVDS----VAKTIDAGCKPYMAPERINPELN 230 Query: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPY--RGMKGSEVTAMLEKGERMGCPAGCPREMYD 603 +S KSD+WS G+ M E + + PY G ++ ++E+ E D Sbjct: 231 QKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVD 289 Query: 604 LMNLCWTYDVENRPGFAAVELR 625 + C + + RP + + Sbjct: 290 FTSQCLKKNSKERPTYPELMQH 311 >1NY3-A nrPDB Length = 400 Score = 201 bits (512), Expect = 7e-52, Method: Composition-based stats. Identities = 56/272 (20%), Positives = 110/272 (40%), Gaps = 32/272 (11%) Query: 368 KLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM-QQ 426 + + LG G G V + + K+ + A+K+L++ + E + + Sbjct: 61 DDYKVTSQVLGLGINGKVLQIFN--KRTQEKFALKMLQDCP-------KARREVELHWRA 111 Query: 427 LDNPYIVRMIGICEA-----ESWMLVMEMAELGPLNKYLQQNRH--VKDKNIIELVHQVS 479 P+IVR++ + E + ++VME + G L +Q ++ E++ + Sbjct: 112 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 171 Query: 480 MGMKYLEESNFVHRDLAARNVLLVT---QHYAKISDFGLSKALRADENYYKAQTHGKWPV 536 ++YL N HRD+ N+L + K++DFG +K + + + T + Sbjct: 172 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK----ETTSHNSLTTPCYTP 227 Query: 537 KWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMG---C 593 + APE + K+ D+WS GV+M+ G P+ G ++ ++ RMG Sbjct: 228 YYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEF 286 Query: 594 P----AGCPREMYDLMNLCWTYDVENRPGFAA 621 P + E+ L+ + R Sbjct: 287 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITE 318 >3KA0-A nrPDB Length = 320 Score = 201 bits (511), Expect = 9e-52, Method: Composition-based stats. Identities = 56/272 (20%), Positives = 110/272 (40%), Gaps = 32/272 (11%) Query: 368 KLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM-QQ 426 + + LG G G V + + K+ + A+K+L++ + E + + Sbjct: 15 DDYKVTSQVLGLGINGKVLQIFN--KRTQEKFALKMLQDCP-------KARREVELHWRA 65 Query: 427 LDNPYIVRMIGICEA-----ESWMLVMEMAELGPLNKYLQQNRH--VKDKNIIELVHQVS 479 P+IVR++ + E + ++VME + G L +Q ++ E++ + Sbjct: 66 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 125 Query: 480 MGMKYLEESNFVHRDLAARNVLLVT---QHYAKISDFGLSKALRADENYYKAQTHGKWPV 536 ++YL N HRD+ N+L + K++DFG +K + + + T + Sbjct: 126 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK----ETTSHNSLTEPCYTP 181 Query: 537 KWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMG---C 593 + APE + K+ D+WS GV+M+ G P+ G ++ ++ RMG Sbjct: 182 YYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEF 240 Query: 594 P----AGCPREMYDLMNLCWTYDVENRPGFAA 621 P + E+ L+ + R Sbjct: 241 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITE 272 >3FME-A nrPDB Length = 290 Score = 201 bits (510), Expect = 1e-51, Method: Composition-based stats. Identities = 60/262 (22%), Positives = 111/262 (42%), Gaps = 20/262 (7%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 ELG G +G V+K + + +AVK ++ N K L+ M+ +D P+ V Sbjct: 14 ELGRGAYGVVEKMRHVPS--GQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTF 71 Query: 436 IGI-CEAESWMLVMEMAELGPLNKY----LQQNRHVKDKNIIELVHQVSMGMKYLEES-N 489 G + ME+ + L+K+ + + + + + + ++ + +++L + Sbjct: 72 YGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 130 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI----N 545 +HRD+ NVL+ K+ DFG+S L D A+ + APE I N Sbjct: 131 VIHRDVKPSNVLINALGQVKMCDFGISGYLVDD----VAKDIDAGCKPYMAPERINPELN 186 Query: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPY--RGMKGSEVTAMLEKGERMGCPAGCPREMYD 603 +S KSD+WS G+ M E + + PY G ++ ++E+ E D Sbjct: 187 QKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVD 245 Query: 604 LMNLCWTYDVENRPGFAAVELR 625 + C + + RP + + Sbjct: 246 FTSQCLKKNSKERPTYPELMQH 267 >5O2B-A nrPDB Length = 285 Score = 201 bits (510), Expect = 1e-51, Method: Composition-based stats. Identities = 61/268 (22%), Positives = 110/268 (41%), Gaps = 22/268 (8%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 D ELG G F TV KG + VA L++ A + EA +++ L +P IV Sbjct: 21 DIELGRGAFKTVYKGLD--TETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIV 78 Query: 434 RMIGICEA-----ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 R E+ + +LV E+ G L YL++ + +K K + Q+ G+++L Sbjct: 79 RFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTR 138 Query: 489 N--FVHRDLAARNVLLV-TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 +HRDL N+ + KI D GL+ +R ++ APE Sbjct: 139 TPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMR-----TSFAKSVIGTPEFMAPEMYE 193 Query: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKG-SEVTAMLEKGERMGCPAGCP-REMYD 603 + DV++FG+ M E + + PY + +++ + G + E+ + Sbjct: 194 E-HYDESVDVYAFGMCMLEMATS-EYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKE 251 Query: 604 LMNLCWTYDVENRPGFAAVELRLRNYYY 631 ++ C + R + L + ++ Sbjct: 252 IIEGCIRQNKSERLS---IRDLLNHAFF 276 >2OZA-A nrPDB Length = 356 Score = 201 bits (510), Expect = 1e-51, Method: Composition-based stats. Identities = 56/272 (20%), Positives = 110/272 (40%), Gaps = 32/272 (11%) Query: 368 KLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM-QQ 426 + + LG G G V + + K+ + A+K+L++ + E + + Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFN--KRTQEKFALKMLQDCP-------KARREVELHWRA 67 Query: 427 LDNPYIVRMIGICEA-----ESWMLVMEMAELGPLNKYLQQNRH--VKDKNIIELVHQVS 479 P+IVR++ + E + ++VME + G L +Q ++ E++ + Sbjct: 68 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 127 Query: 480 MGMKYLEESNFVHRDLAARNVLLVT---QHYAKISDFGLSKALRADENYYKAQTHGKWPV 536 ++YL N HRD+ N+L + K++DFG +K + + + T + Sbjct: 128 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAK----ETTSHNSLTTPCYTP 183 Query: 537 KWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMG---C 593 + APE + K+ D+WS GV+M+ G P+ G ++ ++ RMG Sbjct: 184 YYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEF 242 Query: 594 P----AGCPREMYDLMNLCWTYDVENRPGFAA 621 P + E+ L+ + R Sbjct: 243 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITE 274 >4O2Z-A nrPDB Length = 377 Score = 201 bits (510), Expect = 1e-51, Method: Composition-based stats. Identities = 58/288 (20%), Positives = 111/288 (38%), Gaps = 44/288 (15%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPY--- 431 K LG G +G + V++K ++ D +L E ++M+ + Sbjct: 51 KILGMGAYGIACSCLDG--DTGEKVSIKKCRDVFRDVEDGKRVLREIDMMRFFHHENLLN 108 Query: 432 IVRMI-----GICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE 486 +V ++ E +V + ++ +N L+ + +++ ++ V+Q+ G+KYL Sbjct: 109 VVNILPPLKREYHSFEDVYVVTPLMDV-DMNVVLRSRQVLEESHMQYFVYQILRGLKYLH 167 Query: 487 ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY 546 +N HRDL N++ KI DFGLS+++ Y T + PE + Sbjct: 168 SANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVP---YSELTDYVITRWYRPPELLLE 224 Query: 547 YK-FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK--GER------------- 590 +S+ D+WS G + E ++ + + G + M+ + G+ Sbjct: 225 NTNYSTAVDIWSVGCIFAEMYNR-KPVFPGRNTMDQLRMIAQHIGKPPASIVEHREALEK 283 Query: 591 --------MGCPAGCP-----REMYDLMNLCWTYDVENRPGFAAVELR 625 + P P E D ++ WT D RP A + Sbjct: 284 LNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAADMLAH 331 >4CRS-A nrPDB Length = 341 Score = 200 bits (509), Expect = 2e-51, Method: Composition-based stats. Identities = 66/264 (25%), Positives = 115/264 (43%), Gaps = 15/264 (5%) Query: 379 SGNFGTVKKGYYQMKKVVKTVAVKILKN-EANDPALKDELLAEANVMQQLD---NPYIVR 434 G+FG V Y K + A+K LK + D L+ E + + ++ +P++V Sbjct: 22 RGHFGKVLLAEY--KNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVN 79 Query: 435 MIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 + + E VME A G L ++ + + + V +G++YL E V+R Sbjct: 80 LFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLHEHKIVYR 138 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKS 553 DL N+LL T+ + KI+DFGL K + + T P ++ APE + ++ Sbjct: 139 DLKLDNLLLDTEGFVKIADFGLCKEGMGYGD--RTSTFCGTP-EFLAPEVLTETSYTRAV 195 Query: 554 DVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDV 613 D W GVL++E G+ P+ G EV + E P E +M + Sbjct: 196 DWWGLGVLIYEML-VGESPFPGDDEEEVFDSIVNDEV-RYPRFLSTEAISIMRRLLRRNP 253 Query: 614 ENRPGFAA--VELRLRNYYYDVVN 635 E R G + E ++ ++ +++ Sbjct: 254 ERRLGASEKDAEDVKKHPFFRLID 277 >6CKI-A nrPDB Length = 316 Score = 200 bits (508), Expect = 2e-51, Method: Composition-based stats. Identities = 57/287 (19%), Positives = 111/287 (38%), Gaps = 39/287 (13%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLD-NP 430 L++ LG G V+ + + AVKI++ + ++ + E ++ Q + Sbjct: 16 LQEDVLGEGAHARVQTCINLI--TSQEYAVKIIEKQPGH--IRSRVFREVEMLYQCQGHR 71 Query: 431 YIVRMIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 ++ +I E + + LV E G + ++ + RH + +V V+ + +L Sbjct: 72 NVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKG 131 Query: 490 FVHRDLAARNVLLVTQHY---AKISDFGLSKALRADENYYKAQTHGKWPV----KWYAPE 542 HRDL N+L + KI DFGL ++ + + T ++ APE Sbjct: 132 IAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAPE 191 Query: 543 CINYYK-----FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSE---------------VT 582 + + + + D+WS GV+++ S G P+ G GS+ + Sbjct: 192 VVEAFSEEASIYDKRCDLWSLGVILYILLS-GYPPFVGRCGSDCGWDRGEACPACQNMLF 250 Query: 583 AMLEKGERMGCPA----GCPREMYDLMNLCWTYDVENRPGFAAVELR 625 +++G+ P DL++ D + R A V Sbjct: 251 ESIQEGK-YEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQH 296 >3REP-A nrPDB Length = 271 Score = 200 bits (508), Expect = 2e-51, Method: Composition-based stats. Identities = 60/279 (21%), Positives = 108/279 (38%), Gaps = 25/279 (8%) Query: 360 PKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLA 419 K +D K L K L + G + KG +Q +V VK+LK + Sbjct: 2 NKHSGIDFKQLNFLTK-LNENHSGELWKGRWQGNDIV----VKVLKVRDWSTRKSRDFNE 56 Query: 420 EANVMQQLDNPYIVRMIGICEAES---WMLVMEMAELGPLNKYLQQNRHV--KDKNIIEL 474 E ++ +P ++ ++G C++ L+ G L L + + ++ Sbjct: 57 ECPRLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKF 116 Query: 475 VHQVSMGMKYLE--ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHG 532 ++ GM +L E L +R+V++ A+IS + + ++ Y Sbjct: 117 ALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQSPGRMY------ 170 Query: 533 KWPVKWYAPECINYYKFSS---KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLE-KG 588 W APE + + +D+WSF VL+WE + + P+ + E+ + +G Sbjct: 171 --APAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTR-EVPFADLSNMEIGMKVALEG 227 Query: 589 ERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 R P G + LM +C D RP F + L Sbjct: 228 LRPTIPPGISPHVSKLMKICMNEDPAKRPKFDMIVPILE 266 >2F9G-A nrPDB Length = 353 Score = 200 bits (508), Expect = 2e-51, Method: Composition-based stats. Identities = 57/294 (19%), Positives = 109/294 (37%), Gaps = 51/294 (17%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 LG G +G V + K + VA+K + + P L E +++ + I+ + Sbjct: 19 LGEGAYGVVCSATH--KPTGEIVAIKKI-EPFDKPLFALRTLREIKILKHFKHENIITIF 75 Query: 437 GICEAESW------MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 I +S+ ++ E+ + L++ + + + D +I ++Q +K L SN Sbjct: 76 NIQRPDSFENFNEVYIIQELMQT-DLHRVI-STQMLSDDHIQYFIYQTLRAVKVLHGSNV 133 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKAL------RADENYYKAQTHGKWPVKWY-APEC 543 +HRDL N+L+ + K+ DFGL++ + ++ ++ +WY APE Sbjct: 134 IHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEV 193 Query: 544 -INYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAML----------------- 585 + K+S DVWS G ++ E F + + G ++ Sbjct: 194 MLTSAKYSRAMDVWSCGCILAELFLR-RPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIE 252 Query: 586 -----EKGERMGCPAGCPREM---------YDLMNLCWTYDVENRPGFAAVELR 625 E + + P E DL+ +D R Sbjct: 253 SPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 >5O2C-A nrPDB Length = 380 Score = 199 bits (507), Expect = 2e-51, Method: Composition-based stats. Identities = 61/268 (22%), Positives = 110/268 (41%), Gaps = 22/268 (8%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 D ELG G F TV KG + VA L++ A + EA +++ L +P IV Sbjct: 30 DIELGRGAFKTVYKGLD--TETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIV 87 Query: 434 RMIGICEA-----ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 R E+ + +LV E+ G L YL++ + +K K + Q+ G+++L Sbjct: 88 RFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTR 147 Query: 489 N--FVHRDLAARNVLLV-TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 +HRDL N+ + KI D GL+ +R ++ APE Sbjct: 148 TPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMR-----TSFAKSVIGTPEFMAPEM-Y 201 Query: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKG-SEVTAMLEKGERMGCPAGCP-REMYD 603 + DV++FG+ M E + + PY + +++ + G + E+ + Sbjct: 202 EEHYDESVDVYAFGMCMLEMATS-EYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKE 260 Query: 604 LMNLCWTYDVENRPGFAAVELRLRNYYY 631 ++ C + R + L + ++ Sbjct: 261 IIEGCIRQNKSERLS---IRDLLNHAFF 285 >4PWN-A nrPDB Length = 274 Score = 199 bits (506), Expect = 3e-51, Method: Composition-based stats. Identities = 61/269 (22%), Positives = 117/269 (43%), Gaps = 21/269 (7%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 D E+G G+F TV KG + VA L++ + + EA +++ L +P IV Sbjct: 15 DIEIGRGSFKTVYKGLD--TETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIV 72 Query: 434 RMIGICEA-----ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 R E+ + +LV E+ G L YL++ + +K K + Q+ G+++L Sbjct: 73 RFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTR 132 Query: 489 N--FVHRDLAARNVLLV-TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 +HRDL N+ + KI D GL+ L ++ K+ ++ APE Sbjct: 133 TPPIIHRDLKCDNIFITGPTGSVKIGDLGLA-TLEKRASFAKSVI---GTPEFMAPEMYE 188 Query: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKG-SEVTAMLEKGERM-GCPAGCPREMYD 603 K+ DV++FG+ M E + + PY + +++ + G + E+ + Sbjct: 189 E-KYDESVDVYAFGMCMLEMATS-EYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKE 246 Query: 604 LMNLCWTYDVENRPGFAAVELRLRNYYYD 632 ++ C + + R ++ L + ++ Sbjct: 247 IIEGCIRQNKDERYS---IKDLLNHAFFQ 272 >4M69-B nrPDB Length = 283 Score = 199 bits (506), Expect = 3e-51, Method: Composition-based stats. Identities = 58/276 (21%), Positives = 128/276 (46%), Gaps = 16/276 (5%) Query: 363 VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDP--ALKDELLAE 420 + ++ L +L + T+ +G Y V +K+ N + ++ E Sbjct: 3 KEIPKEHLGPPWTKLKTSKMSTIYRGEYHRSPVT----IKVFNNPQAESVGIVRFTFNDE 58 Query: 421 ANVMQQLDNPYIVRMIGICEAES-----WMLVMEMAELGPLNKYLQQNRHVKDKNIIELV 475 M++ D+P I+R+ GIC ++ + +VME ELG L + L + + + LV Sbjct: 59 IKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLV 118 Query: 476 HQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGK-W 534 + + G+ L S +HR++++ + L+ + K++ F LSK + K+ + Sbjct: 119 LRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSS 178 Query: 535 PVKWYAPECIN--YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERM- 591 + +PE + + + K++++SFG+++WE + G+ P+ G ++ ++ + ++ Sbjct: 179 STIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIAT-GKIPFEGCDSKKIRELVAEDKKQE 237 Query: 592 GCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 CP + +++N C ++ RP + RL Sbjct: 238 PVGQDCPELLREIINECRAHEPSQRPSVDGILERLS 273 >4OTD-A nrPDB Length = 341 Score = 199 bits (506), Expect = 3e-51, Method: Composition-based stats. Identities = 71/267 (26%), Positives = 117/267 (43%), Gaps = 17/267 (6%) Query: 364 YLDRKLLTLEDKE----LGSGNFGTVKKGYYQMKKVVKTVAVKILKN-EANDPALKDELL 418 L + LTLED + LG G+FG V ++ + A+K LK + + L+ Sbjct: 3 MLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPS--GELFAIKALKKGDIVARDEVESLM 60 Query: 419 AEANVMQQL---DNPYIVRMIGICEA-ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIEL 474 E ++ + +P++V + G + E VME + G L ++ + + I Sbjct: 61 CEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFY 119 Query: 475 VHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKW 534 V +G+++L E V+RDL N+LL T+ Y KI+DFGL K + + T Sbjct: 120 SACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGD--RTSTFCGT 177 Query: 535 PVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP 594 P ++ APE + ++ D W GVL++E G+ P+ G EV + E P Sbjct: 178 P-EFLAPEVLTDTSYTRAVDWWGLGVLLYEML-VGESPFPGDDEEEVFDSIVNDEV-RYP 234 Query: 595 AGCPREMYDLMNLCWTYDVENRPGFAA 621 E +M + E R G + Sbjct: 235 RFLSAEAIGIMRRLLRRNPERRLGSSE 261 >2A1A-B nrPDB Length = 284 Score = 199 bits (506), Expect = 3e-51, Method: Composition-based stats. Identities = 61/288 (21%), Positives = 118/288 (40%), Gaps = 41/288 (14%) Query: 361 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 420 K +D K + L +GSG FG V K +++ KT +K +K ++ E Sbjct: 7 KRFGMDFKEIEL----IGSGGFGQVFKAKHRID--GKTYVIKRVKYNN------EKAERE 54 Query: 421 ANVMQQLDNPYIVRMIGICE-----------------AESWMLVMEMAELGPLNKYLQQN 463 + +LD+ IV G + + + ME + G L +++++ Sbjct: 55 VKALAKLDHVNIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKR 114 Query: 464 R--HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRA 521 R + +EL Q++ G+ Y+ ++RDL N+ LV KI DFGL +L+ Sbjct: 115 RGEKLDKVLALELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKN 174 Query: 522 DENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 D +T K +++ +PE I+ + + D+++ G+++ E + S+ Sbjct: 175 DG----KRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFE---TSKF 227 Query: 582 TAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNY 629 L G ++ L+ + E+RP + + L + Sbjct: 228 FTDLRDGI---ISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVW 272 >3OHT-A nrPDB Length = 389 Score = 199 bits (505), Expect = 4e-51, Method: Composition-based stats. Identities = 55/257 (21%), Positives = 107/257 (41%), Gaps = 25/257 (9%) Query: 340 ALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTV 399 M + E P +E+ + + TL +GSG +G+V Y K + Sbjct: 26 PFTMSHK--ERPTFYRQELNKTIWEVPERYQTLS--PVGSGAYGSVCSSYDV--KSGLKI 79 Query: 400 AVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC-------EAESWMLVMEMAE 452 AVK L E +++ + + ++ ++ + E LV + Sbjct: 80 AVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLM- 138 Query: 453 LGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISD 512 LN + + + + D ++ L++Q+ G+KY+ ++ +HRDL N+ + KI D Sbjct: 139 GADLNN-IVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILD 197 Query: 513 FGLSKALRADENYYKAQTHGKWPVKWY-APEC-INYYKFSSKSDVWSFGVLMWEAFSYGQ 570 FGL++ + + G +WY APE +N+ ++ D+WS G +M E + G+ Sbjct: 198 FGLAR-------HTDDEMTGYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLT-GR 249 Query: 571 KPYRGMKGSEVTAMLEK 587 + G + + Sbjct: 250 TLFPGTDHINQLQQIMR 266 >4MWI-A nrPDB Length = 294 Score = 198 bits (504), Expect = 5e-51, Method: Composition-based stats. Identities = 65/294 (22%), Positives = 136/294 (46%), Gaps = 24/294 (8%) Query: 349 ESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKN-- 406 E P +EI+ +++ +L E++ T+ KG Y VA+K+ K Sbjct: 10 EIPQEQIKEIKKEQLSGSPWILLRENEV------STLYKGEYH----RAPVAIKVFKKLQ 59 Query: 407 EANDPALKDELLAEANVMQQLDNPYIVRMIGICEAES-----WMLVMEMAELGPLNKYLQ 461 + ++ E M++ ++P I+R+ GIC E+ + +VME ELG L + L Sbjct: 60 AGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLD 119 Query: 462 QNRHVKDKNIIELVHQVSMGMKYLEESNF--VHRDLAARNVLLVTQHYAKISDFGLSKAL 519 + + + + LV + G+ L S +H + + N L+ + K++ F L K Sbjct: 120 REKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQ 179 Query: 520 RA-DENYYKAQTHGKWPVKWYAPECIN--YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGM 576 + + +T + +P+ + +Y++ KS+++SFG+++WE + G P++G Sbjct: 180 TSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIAT-GDIPFQGC 238 Query: 577 KGSEVTAMLE-KGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNY 629 ++ ++ K ++ CP E+ ++++ C +D RP + +L + Sbjct: 239 NSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTF 292 >3QA8-A nrPDB Length = 676 Score = 198 bits (504), Expect = 5e-51, Method: Composition-based stats. Identities = 61/212 (28%), Positives = 103/212 (48%), Gaps = 21/212 (9%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 + LG+G FG V + +Q + VA+K + E P ++ E +M++L++P +V Sbjct: 20 ERLGTGGFGYVLRWIHQ--DTGEQVAIKQCRQEL-SPKNRERWCLEIQIMKKLNHPNVVS 76 Query: 435 MIGICEA-------ESWMLVMEMAELGPLNKYLQQNRH---VKDKNIIELVHQVSMGMKY 484 + + + +L ME E G L KYL Q + +K+ I L+ +S ++Y Sbjct: 77 AREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSALRY 136 Query: 485 LEESNFVHRDLAARNVLLV---TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 541 L E+ +HRDL N++L + KI D G +K L E T +++ AP Sbjct: 137 LHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGE----LCTEFVGTLQYLAP 192 Query: 542 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPY 573 E + K++ D WSFG L +E + G +P+ Sbjct: 193 ELLEQKKYTVTVDYWSFGTLAFECIT-GFRPF 223 >5KKR-C nrPDB Length = 395 Score = 198 bits (504), Expect = 5e-51, Method: Composition-based stats. Identities = 75/368 (20%), Positives = 141/368 (38%), Gaps = 57/368 (15%) Query: 303 HRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKE 362 +K +P Q N + N A + + E L +D + + K Sbjct: 5 KKKPTPIQLNPAPDGSAVNGTSSAETNLEALQ-KKLEELELDEQQ-RKRLEAFLTQKQKV 62 Query: 363 VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEAN 422 L + ELG+GN G V K ++ +V +A K++ E PA++++++ E Sbjct: 63 GELKDDDFE-KISELGAGNGGVVFKVSHKPSGLV--MARKLIHLEI-KPAIRNQIIRELQ 118 Query: 423 VMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMG 481 V+ + ++PYIV G ++ + + ME + G L++ L++ + ++ + ++ V G Sbjct: 119 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 178 Query: 482 MKYL-EESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540 + YL E+ +HRD+ N+L+ ++ K+ DFG+S L T + + Sbjct: 179 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS-----YMS 233 Query: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAM---------------- 584 PE + +S +SD+WS G+ + E + G+ P E+ M Sbjct: 234 PERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPIPPPDAKELELMFGCQVEGDAAETPPRP 292 Query: 585 ---------LEKGERMGC-------------PAGCPR-----EMYDLMNLCWTYDVENRP 617 R P P E D +N C + R Sbjct: 293 RTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERA 352 Query: 618 GFAAVELR 625 + + Sbjct: 353 DLKQLMVH 360 >6J5U-C nrPDB Length = 426 Score = 198 bits (504), Expect = 6e-51, Method: Composition-based stats. Identities = 79/284 (27%), Positives = 122/284 (42%), Gaps = 33/284 (11%) Query: 373 EDKELGSGNFGTVKKGYYQMK-------KVVKTVAVKILKNEANDPALKDELLAEANVMQ 425 +D LG G FG V KG+ VAVK LK E E L E N + Sbjct: 88 QDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQG--HKEWLTEVNYLG 145 Query: 426 QLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNR--HVKDKNIIELVHQVSMGM 482 QL +P +V ++G C E E+ +LV E G L +L + + +++ + G+ Sbjct: 146 QLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGAAKGL 205 Query: 483 KYLEESN--FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540 +L E+ ++RD A N+LL AK+SDFGL+KA +N T + A Sbjct: 206 TFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDN-THVSTKVIGTHGYAA 264 Query: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQ-----------------KPYRGMKGSEVTA 583 PE + + ++KSDV+SFGV++ E S + PY G K ++ Sbjct: 265 PEYVATGRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLVDWATPYLGDK-RKLFR 323 Query: 584 MLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 +++ P +L C D + RP + V + L Sbjct: 324 IMDTKLGGQYPQKGAFTAANLALQCLNPDAKLRPKMSEVLVTLE 367 >5B2L-A nrPDB Length = 324 Score = 198 bits (503), Expect = 7e-51, Method: Composition-based stats. Identities = 68/262 (25%), Positives = 116/262 (44%), Gaps = 21/262 (8%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 E+GSG G V K + +K +AVK ++ N K L+ V++ D PYIV+ Sbjct: 24 EMGSGTCGQVWK--MRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQC 81 Query: 436 IGICEAESWMLV-MEMAELGPLNKYLQQN--RHVKDKNIIELVHQVSMGMKYL-EESNFV 491 G + + + ME+ G + L++ + ++ + ++ + + YL E+ + Sbjct: 82 FGTFITNTDVFIAMELM--GTSAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI 139 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN-----Y 546 HRD+ N+LL + K+ DFG+S L KA+T + APE I+ Sbjct: 140 HRDVKPSNILLDERGQIKLCDFGISGRLVDS----KAKTRSAGCAAYMAPERIDPPDPTK 195 Query: 547 YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGS-EVTAMLEKGERMGCP--AGCPREMYD 603 + ++DVWS G+ + E + GQ PY+ K EV + + E P G + Sbjct: 196 PDYDIRADVWSLGISLVE-LATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQS 254 Query: 604 LMNLCWTYDVENRPGFAAVELR 625 + C T D RP + + Sbjct: 255 FVKDCLTKDHRKRPKYNKLLEH 276 >3GC9-A nrPDB Length = 370 Score = 198 bits (503), Expect = 7e-51, Method: Composition-based stats. Identities = 54/239 (22%), Positives = 105/239 (43%), Gaps = 25/239 (10%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 + +GSG +G+V Y ++ + VAVK L E +++ L + ++ Sbjct: 34 RPVGSGAYGSVCSAYDA--RLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIG 91 Query: 435 MIGICEA-------ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 487 ++ + LV + LN + +++ + D+++ LV+Q+ G+KY+ Sbjct: 92 LLDVFTPATSIEDFSEVYLVTTLM-GADLNN-IVKSQALSDEHVQFLVYQLLRGLKYIHS 149 Query: 488 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APEC-IN 545 + +HRDL NV + +I DFGL++ + G +WY APE +N Sbjct: 150 AGIIHRDLKPSNVAVNEDSELRILDFGLARQ-------ADEEMTGYVATRWYRAPEIMLN 202 Query: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDL 604 + ++ D+WS G +M E G+ + G + + E +G P+ P + + Sbjct: 203 WMHYNQTVDIWSVGCIMAELL-QGKALFPGSDYIDQLKRIM--EVVGTPS--PEVLAKI 256 >3MIA-A nrPDB Length = 351 Score = 197 bits (502), Expect = 8e-51, Method: Composition-based stats. Identities = 64/286 (22%), Positives = 109/286 (38%), Gaps = 51/286 (17%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 ++G G FG V K ++ K + VA+K + E L E ++Q L + +V + Sbjct: 24 KIGQGTFGEVFKARHR--KTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNL 81 Query: 436 IGICEAE---------SWMLVMEMAEL---GPLNKYLQQNRHVKDKNIIELVHQVSMGMK 483 I IC + S LV + E G L+ L + I ++ + G+ Sbjct: 82 IEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIKRVMQMLLNGLY 138 Query: 484 YLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APE 542 Y+ + +HRD+ A NVL+ K++DFGL++A +N + + WY PE Sbjct: 139 YIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPE 198 Query: 543 CINYYK-FSSKSDVWSFGVLMWEA---------------------FSYGQKP--YRGMKG 578 + + + D+W G +M E P + + Sbjct: 199 LLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDN 258 Query: 579 SEVTAMLE--KG------ERMGCPAGCPREMYDLMNLCWTYDVENR 616 E+ LE KG +R+ P + DL++ D R Sbjct: 259 YELYEKLELVKGQKRKVKDRLKAYVRDPYAL-DLIDKLLVLDPAQR 303 >4KIK-B nrPDB Length = 677 Score = 197 bits (502), Expect = 1e-50, Method: Composition-based stats. Identities = 56/212 (26%), Positives = 102/212 (48%), Gaps = 21/212 (9%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 + LG+G FG V + + ++ + +A+K + E P ++ E +M++L +P +V Sbjct: 25 ERLGTGGFGNVIR--WHNQETGEQIAIKQCRQEL-SPRNRERWCLEIQIMRRLTHPNVVA 81 Query: 435 MIGICEA-------ESWMLVMEMAELGPLNKYLQQNRH---VKDKNIIELVHQVSMGMKY 484 + E + +L ME + G L KYL Q + +++ I+ L+ ++ ++Y Sbjct: 82 ARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRY 141 Query: 485 LEESNFVHRDLAARNVLLVTQHY---AKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 541 L E+ +HRDL N++L KI D G +K L T +++ AP Sbjct: 142 LHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGS----LCTSFVGTLQYLAP 197 Query: 542 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPY 573 E + K++ D WSFG L +E + G +P+ Sbjct: 198 ELLEQQKYTVTVDYWSFGTLAFECIT-GFRPF 228 >4IDT-A nrPDB Length = 356 Score = 197 bits (501), Expect = 1e-50, Method: Composition-based stats. Identities = 67/300 (22%), Positives = 112/300 (37%), Gaps = 19/300 (6%) Query: 330 WAADKGPQREALPMDTEVYESPYADPEEIRPKEV-YLDRKLLTLEDKELGSGNFGTVKKG 388 WAA RE P TE E E+++P + Y + LG G+FG V + Sbjct: 36 WAARGSRSREPSP-KTEDNEGVLLT-EKLKPVDYEYREEVHWATHQLRLGRGSFGEVHR- 92 Query: 389 YYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWM-LV 447 + K+ AVK ++ E E L +P IV + G W+ + Sbjct: 93 -MEDKQTGFQCAVKKVRLEVFRA-------EELMACAGLTSPRIVPLYGAVREGPWVNIF 144 Query: 448 MEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQH- 506 ME+ E G L + +++ + + + + Q G++YL +H D+ A NVLL + Sbjct: 145 MELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGS 204 Query: 507 YAKISDFGLSKALRAD--ENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWE 564 +A + DFG + L+ D + APE + +K DVWS +M Sbjct: 205 HAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLH 264 Query: 565 AFSYGQKPYRGMKGSEVTAMLEKGERM--GCPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 + G P+ + + P C + + +R A + Sbjct: 265 MLN-GCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAEL 323 >3EQC-A nrPDB Length = 360 Score = 197 bits (501), Expect = 1e-50, Method: Composition-based stats. Identities = 69/336 (20%), Positives = 131/336 (38%), Gaps = 56/336 (16%) Query: 335 GPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKK 394 G + E L +D + + K L + ELG+GN G V K ++ Sbjct: 1 GKKLEELELDEQQ-RKRLEAFLTQKQKVGELKDDDFE-KISELGAGNGGVVFKVSHKPSG 58 Query: 395 VVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWM-LVMEMAEL 453 +V +A K++ E PA++++++ E V+ + ++PYIV G ++ + + ME + Sbjct: 59 LV--MARKLIHLEI-KPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDG 115 Query: 454 GPLNKYLQQNRHVKDKNIIELVHQVSMGMKYL-EESNFVHRDLAARNVLLVTQHYAKISD 512 G L++ L++ + ++ + ++ V G+ YL E+ +HRD+ N+L+ ++ K+ D Sbjct: 116 GSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCD 175 Query: 513 FGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKP 572 FG+S L T + +PE + +S +SD+WS G+ + E + G+ P Sbjct: 176 FGVSGQLIDSMANSFVGTRS-----YMSPERLQGTHYSVQSDIWSMGLSLVEM-AVGRYP 229 Query: 573 YRGMKGSEV-------------------------TAMLEKGERMGC-------------P 594 E+ R P Sbjct: 230 IPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLNKFGMDSRPPMAIFELLDYIVNEPP 289 Query: 595 AGCPR-----EMYDLMNLCWTYDVENRPGFAAVELR 625 P E D +N C + R + + Sbjct: 290 PKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVH 325 >3ALO-A nrPDB Length = 327 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 63/266 (23%), Positives = 115/266 (43%), Gaps = 24/266 (9%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 E+G G +G+V K + K + +AVK +++ ++ K L+ VM+ D PYIV+ Sbjct: 29 EIGRGAYGSVNKMVH--KPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQF 86 Query: 436 IGICEAESWM-LVMEMAELGPLNKYLQQ-----NRHVKDKNIIELVHQVSMGMKYLEES- 488 G E + ME+ +K+ + + + ++ + ++ + +L+E+ Sbjct: 87 YGALFREGDCWICMELMST-SFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENL 145 Query: 489 NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI---- 544 +HRD+ N+LL K+ DFG+S L A+T + APE I Sbjct: 146 KIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDS----IAKTRDAGCRPYMAPERIDPSA 201 Query: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKG-SEVTAMLEKGERMGC----PAGCPR 599 + + +SDVWS G+ ++E + G+ PY + + KG+ Sbjct: 202 SRQGYDVRSDVWSLGITLYE-LATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSP 260 Query: 600 EMYDLMNLCWTYDVENRPGFAAVELR 625 + +NLC T D RP + + Sbjct: 261 SFINFVNLCLTKDESKRPKYKELLKH 286 >4YHJ-A nrPDB Length = 584 Score = 196 bits (499), Expect = 2e-50, Method: Composition-based stats. Identities = 53/250 (21%), Positives = 105/250 (42%), Gaps = 16/250 (6%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDEL-LAEANVMQQLDNPYIV 433 + LG G FG V Q++ K A K L+ + + + L E +++++ + ++V Sbjct: 191 RVLGKGGFGEVCAC--QVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVV 248 Query: 434 RMIGICEA-ESWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGMKYLEESNF 490 + E ++ LV+ + G L ++ N ++ + ++ G++ L+ Sbjct: 249 SLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERI 308 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 V+RDL N+LL + + +ISD GL+ + + V + APE +N K++ Sbjct: 309 VYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVR----GRVGTVGYMAPEVVNNEKYT 364 Query: 551 SKSDVWSFGVLMWEAFSYGQKPY----RGMKGSEVTAMLEKGERMGCPAGCPREMYDLMN 606 D W G L++E G P+ +K EV + K + + + Sbjct: 365 FSPDWWGLGCLIYEMI-QGHSPFKKYKEKVKWEEVDQRI-KNDTEEYSEKFSEDAKSICR 422 Query: 607 LCWTYDVENR 616 + T + R Sbjct: 423 MLLTKNPSKR 432 >5O0Y-A nrPDB Length = 579 Score = 196 bits (498), Expect = 3e-50, Method: Composition-based stats. Identities = 69/266 (25%), Positives = 115/266 (43%), Gaps = 28/266 (10%) Query: 382 FGTVKKGYYQMKKVVKTVAVKI--LKN---EANDPALKDELLAEANVMQQLDNPYIVRMI 436 F V K + ++ + VAVKI L + E + ++LD+P IV++ Sbjct: 297 FSEVYKAFDLTEQ--RYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLY 354 Query: 437 GIC--EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN--FVH 492 + +S+ V+E E L+ YL+Q++ + +K ++ Q+ +KYL E +H Sbjct: 355 DYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIH 414 Query: 493 RDLAARNVLLVTQ---HYAKISDFGLSKALRADE----NYYKAQTHGKWPVKWYAPECI- 544 DL N+LLV KI+DFGLSK + D + + + G + PEC Sbjct: 415 YDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFV 474 Query: 545 ---NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAM---LEKGERMGCPAG-- 596 K S+K DVWS GV+ ++ YG+KP+ + + + K + P Sbjct: 475 VGKEPPKISNKVDVWSVGVIFYQCL-YGRKPFGHNQSQQDILQENTILKATEVQFPPKPV 533 Query: 597 CPREMYDLMNLCWTYDVENRPGFAAV 622 E + C Y E+R + Sbjct: 534 VTPEAKAFIRRCLAYRKEDRIDVQQL 559 >6GVJ-A nrPDB Length = 429 Score = 195 bits (496), Expect = 5e-50, Method: Composition-based stats. Identities = 54/267 (20%), Positives = 107/267 (40%), Gaps = 23/267 (8%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL--DNPYI 432 K++GSG V + + K + A+K + E D D E + +L + I Sbjct: 150 KQIGSGGSSKVFQVLNEKK---QIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKI 206 Query: 433 VRMIGI-CEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFV 491 +R+ + +VME LN +L++ + + + + + + V Sbjct: 207 IRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIV 265 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 H DL N L+V K+ DFG++ ++ D + V + PE I S Sbjct: 266 HSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQ-VGTVNYMPPEAIKDMSSSR 323 Query: 552 K-----------SDVWSFGVLMWEAFSYGQKPYRGMKG--SEVTAMLEKGERMGCPAGCP 598 + SDVWS G +++ +YG+ P++ + S++ A+++ + P Sbjct: 324 ENGKSKSKISPKSDVWSLGCILYYM-TYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPE 382 Query: 599 REMYDLMNLCWTYDVENRPGFAAVELR 625 +++ D++ C D + R + Sbjct: 383 KDLQDVLKCCLKRDPKQRISIPELLAH 409 >3UIU-A nrPDB Length = 306 Score = 195 bits (496), Expect = 5e-50, Method: Composition-based stats. Identities = 61/301 (20%), Positives = 118/301 (39%), Gaps = 54/301 (17%) Query: 361 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 420 K +D K + L +GSG FG V K +++ KT ++ +K ++ E Sbjct: 8 KRFGMDFKEIEL----IGSGGFGQVFKAKHRID--GKTYVIRRVKYNN------EKAERE 55 Query: 421 ANVMQQLDNPYIVRMIGICE------------------------------AESWMLVMEM 450 + +LD+ IV G + + + ME Sbjct: 56 VKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEF 115 Query: 451 AELGPLNKYLQQNR--HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA 508 + G L +++++ R + +EL Q++ G+ Y+ +HRDL N+ LV Sbjct: 116 CDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQV 175 Query: 509 KISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSY 568 KI DFGL +L+ D +T K +++ +PE I+ + + D+++ G+++ E Sbjct: 176 KIGDFGLVTSLKNDG----KRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHV 231 Query: 569 GQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 628 + S+ L G ++ L+ + E+RP + + L Sbjct: 232 CDTAFE---TSKFFTDLRDGI---ISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTV 285 Query: 629 Y 629 + Sbjct: 286 W 286 >1S9I-A nrPDB Length = 354 Score = 195 bits (496), Expect = 5e-50, Method: Composition-based stats. Identities = 65/256 (25%), Positives = 124/256 (48%), Gaps = 16/256 (6%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 ELG+GN G V K ++ + +A K++ E PA++++++ E V+ + ++PYIV Sbjct: 23 ELGAGNGGVVTKVQHRPSGL--IMARKLIHLEI-KPAIRNQIIRELQVLHECNSPYIVGF 79 Query: 436 IGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN-FVHR 493 G ++ + + ME + G L++ L++ + + ++ + ++ V G+ YL E + +HR Sbjct: 80 YGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHR 139 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKS 553 D+ N+L+ ++ K+ DFG+S L T + APE + +S +S Sbjct: 140 DVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS-----YMAPERLQGTHYSVQS 194 Query: 554 DVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK----GERMGCPAGCPREMYDLMNLCW 609 D+WS G+ + E + G+ P E+ A+ + GE G P Sbjct: 195 DIWSMGLSLVE-LAVGRYPIPPPDAKELEAIFGRPVVDGEE-GEPHSISPRPRPPGRPVS 252 Query: 610 TYDVENRPGFAAVELR 625 + +++RP A EL Sbjct: 253 GHGMDSRPAMAIFELL 268 >3DLS-A nrPDB Length = 335 Score = 195 bits (495), Expect = 5e-50, Method: Composition-based stats. Identities = 56/258 (21%), Positives = 109/258 (42%), Gaps = 25/258 (9%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEA-------NDPALKDELLAEANVMQQLD 428 LGSG FG V + K K V VK +K E DP L L E ++ +++ Sbjct: 31 PLGSGAFGFVWTAVDKEKN--KEVVVKFIKKEKVLEDCWIEDPKLGKVTL-EIAILSRVE 87 Query: 429 NPYIVRMIGICEAESWM-LVMEMAELG-PLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE 486 + I++++ I E + + LVME G L ++ ++ + + + Q+ + YL Sbjct: 88 HANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLR 147 Query: 487 ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY 546 + +HRD+ N+++ K+ DFG + L + +Y +++ APE + Sbjct: 148 LKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYT----FCGTIEYCAPEVLMG 203 Query: 547 YKF-SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLM 605 + + ++WS GV ++ + + P+ E+ +E P +E+ L+ Sbjct: 204 NPYRGPELEMWSLGVTLYTLV-FEENPFC-----ELEETVEAAIHP--PYLVSKELMSLV 255 Query: 606 NLCWTYDVENRPGFAAVE 623 + E R + Sbjct: 256 SGLLQPVPERRTTLEKLV 273 >5G6V-A nrPDB Length = 324 Score = 195 bits (495), Expect = 6e-50, Method: Composition-based stats. Identities = 54/226 (23%), Positives = 100/226 (44%), Gaps = 11/226 (4%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 +LG G + TV KG + K VA+K ++ E + A + E ++++ L + IV + Sbjct: 9 KLGEGTYATVYKG--KSKLTDNLVALKEIRLEHEEGAPC-TAIREVSLLKDLKHANIVTL 65 Query: 436 IGICEAE-SWMLVMEMAELGPLNKYLQQNRHV-KDKNIIELVHQVSMGMKYLEESNFVHR 493 I E S LV E + L +YL ++ N+ + Q+ G+ Y +HR Sbjct: 66 HDIIHTEKSLTLVFEYLDK-DLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHR 124 Query: 494 DLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY-YKFSSK 552 DL +N+L+ + K++DFGL++A Y + W + P+ + +S++ Sbjct: 125 DLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLW---YRPPDILLGSTDYSTQ 181 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCP 598 D+W G + +E + G+ + G E + + P Sbjct: 182 IDMWGVGCIFYEMAT-GRPLFPGSTVEEQLHFIFRILGTPTEETWP 226 >3HMP-A nrPDB Length = 342 Score = 195 bits (495), Expect = 7e-50, Method: Composition-based stats. Identities = 54/267 (20%), Positives = 107/267 (40%), Gaps = 23/267 (8%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL--DNPYI 432 K++GSG V + + K + A+K + E D D E + +L + I Sbjct: 62 KQIGSGGSSKVFQVLNEKK---QIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKI 118 Query: 433 VRMIGI-CEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFV 491 +R+ + +VME LN +L++ + + + + + + V Sbjct: 119 IRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIV 177 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 H DL N L+V K+ DFG++ ++ D + V + PE I S Sbjct: 178 HSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQ-VGTVNYMPPEAIKDMSSSR 235 Query: 552 K-----------SDVWSFGVLMWEAFSYGQKPYRGMKG--SEVTAMLEKGERMGCPAGCP 598 + SDVWS G +++ +YG+ P++ + S++ A+++ + P Sbjct: 236 ENGKSKSKISPKSDVWSLGCILYYM-TYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPE 294 Query: 599 REMYDLMNLCWTYDVENRPGFAAVELR 625 +++ D++ C D + R + Sbjct: 295 KDLQDVLKCCLKRDPKQRISIPELLAH 321 >5TQX-A nrPDB Length = 655 Score = 194 bits (494), Expect = 8e-50, Method: Composition-based stats. Identities = 61/277 (22%), Positives = 117/277 (42%), Gaps = 43/277 (15%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 + LG+G FG V YQ +++ +A+K + E + ++ E +M++L++ +V+ Sbjct: 14 ERLGTGGFGNV--CLYQHRELDLKIAIKSCRLELSTKN-RERWCHEIQIMKKLNHANVVK 70 Query: 435 MIGICEA------ESWMLVMEMAELGPLNKYLQQNRH---VKDKNIIELVHQVSMGMKYL 485 + E + +L ME G L K L + + +K+ I+ L+ + G++YL Sbjct: 71 ACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYL 130 Query: 486 EESNFVHRDLAARNVLLVTQH---YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 542 E+ +HRDL N++L KI D G +K + E T +++ APE Sbjct: 131 HENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGE----LCTEFVGTLQYLAPE 186 Query: 543 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPY----RGMKGSEVTAM-------------- 584 +++ D WSFG +++E + G +P+ + E Sbjct: 187 LFENKPYTATVDYWSFGTMVFECIA-GYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSG 245 Query: 585 -LEKGERMGCP-AGCP---REMYDLMNLCWTYDVENR 616 + + P + C M + + L +D + R Sbjct: 246 EVRFSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQR 282 >1ZXE-A nrPDB Length = 303 Score = 193 bits (491), Expect = 2e-49, Method: Composition-based stats. Identities = 54/279 (19%), Positives = 103/279 (36%), Gaps = 40/279 (14%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 435 LG G FG V K + + A+K +++ + +L+E ++ L++ Y+VR Sbjct: 13 VLGQGAFGQVVKARNALD--SRYYAIKKIRHTEEKLS---TILSEVMLLASLNHQYVVRY 67 Query: 436 IGIC--------------EAESWMLVMEMAELGPLNKYLQ-QNRHVKDKNIIELVHQVSM 480 + + + ME E L + +N + + L Q+ Sbjct: 68 YAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQILE 127 Query: 481 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQ----------- 529 + Y+ +HR+L N+ + KI DFGL+K + + K Sbjct: 128 ALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSSDNL 187 Query: 530 THGKWPVKWYAPECINY-YKFSSKSDVWSFGVLMWEAFSYGQKPYR-GMKGSEVTAMLEK 587 T + A E ++ ++ K D++S G++ +E P+ GM+ + L Sbjct: 188 TSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI----YPFSTGMERVNILKKLRS 243 Query: 588 GERMGCPAGCPREM---YDLMNLCWTYDVENRPGFAAVE 623 P +M ++ L +D RPG + Sbjct: 244 VSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLL 282 >5AP3-A nrPDB Length = 313 Score = 193 bits (491), Expect = 2e-49, Method: Composition-based stats. Identities = 54/267 (20%), Positives = 107/267 (40%), Gaps = 23/267 (8%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL--DNPYI 432 K++GSG V + + K + A+K + E D D E + +L + I Sbjct: 34 KQIGSGGSSKVFQVLNEKK---QIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKI 90 Query: 433 VRMIGI-CEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFV 491 +R+ + +VME LN +L++ + + + + + + V Sbjct: 91 IRLYDYEITDQYIYMVME-CGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIV 149 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 H DL N L+V K+ DFG++ ++ D + V + PE I S Sbjct: 150 HSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQ-VGTVNYMPPEAIKDMSSSR 207 Query: 552 K-----------SDVWSFGVLMWEAFSYGQKPYRGMKG--SEVTAMLEKGERMGCPAGCP 598 + SDVWS G +++ +YG+ P++ + S++ A+++ + P Sbjct: 208 ENGKSKSKISPKSDVWSLGCILYYM-TYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPE 266 Query: 599 REMYDLMNLCWTYDVENRPGFAAVELR 625 +++ D++ C D + R + Sbjct: 267 KDLQDVLKCCLKRDPKQRISIPELLAH 293 >2Y4I-B nrPDB Length = 319 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 60/287 (20%), Positives = 116/287 (40%), Gaps = 24/287 (8%) Query: 356 EEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKD 415 I +E + + L + + +G G FG V G + VA++++ E ++ Sbjct: 21 TSIFLQEWDIPFEQLEI-GELIGKGRFGQVYHGRWHG-----EVAIRLIDIERDNEDQLK 74 Query: 416 ELLAEANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNR-HVKDKNIIE 473 E +Q + +V +G C + + ++ + + L ++ + + + Sbjct: 75 AFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQ 134 Query: 474 LVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGL---SKALRADENYYKAQT 530 + ++ GM YL +H+DL ++NV I+DFGL S L+A K + Sbjct: 135 IAQEIVKGMGYLHAKGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRI 193 Query: 531 HGKWPVKWYAPECINY---------YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 W APE I FS SDV++ G + +E + + P++ + Sbjct: 194 QNGWLCH-LAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAR-EWPFKTQPAEAI 251 Query: 582 TAMLEKGERMGCPA-GCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 + G + G +E+ D++ CW ++ E RP F + L Sbjct: 252 IWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLE 298 >4M7I-A nrPDB Length = 299 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 51/287 (17%), Positives = 112/287 (39%), Gaps = 40/287 (13%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 LG G FG V + ++ A+K ++ + A +++++ E + +L++P IVR Sbjct: 13 LGRGGFGVVFEAKNKVDDCN--YAIKRIRLPNRELA-REKVMREVKALAKLEHPGIVRYF 69 Query: 437 GICEAES-------------WMLVMEMAELGPLNKYLQQNRHVKDKNI---IELVHQVSM 480 ++ + M++ L ++ ++++ + + Q++ Sbjct: 70 NAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAE 129 Query: 481 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENY---------YKAQTH 531 +++L +HRDL N+ K+ DFGL A+ DE Y T Sbjct: 130 AVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTG 189 Query: 532 GKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERM 591 + +PE I+ +S K D++S G++++E P+ E L + Sbjct: 190 QVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELL----YPFS--TQMERVRTLTDVRNL 243 Query: 592 GCPAGCPREM---YDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 P ++ Y ++ + RP + + N ++ ++ Sbjct: 244 KFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINI---IENAVFEDLD 287 >2ZMD-A nrPDB Length = 390 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 54/267 (20%), Positives = 107/267 (40%), Gaps = 23/267 (8%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL--DNPYI 432 K++GSG V + + K + A+K + E D D E + +L + I Sbjct: 62 KQIGSGGSSKVFQVLNEKK---QIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKI 118 Query: 433 VRMIGI-CEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFV 491 +R+ + +VME LN +L++ + + + + + + V Sbjct: 119 IRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIV 177 Query: 492 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 551 H DL N L+V K+ DFG++ ++ D + V + PE I S Sbjct: 178 HSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQ-VGAVNYMPPEAIKDMSSSR 235 Query: 552 K-----------SDVWSFGVLMWEAFSYGQKPYRGMKG--SEVTAMLEKGERMGCPAGCP 598 + SDVWS G +++ +YG+ P++ + S++ A+++ + P Sbjct: 236 ENGKSKSKISPKSDVWSLGCILYYM-TYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPE 294 Query: 599 REMYDLMNLCWTYDVENRPGFAAVELR 625 +++ D++ C D + R + Sbjct: 295 KDLQDVLKCCLKRDPKQRISIPELLAH 321 >4U41-A nrPDB Length = 332 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 55/267 (20%), Positives = 105/267 (39%), Gaps = 25/267 (9%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL-DNPYIV 433 + +G+G +G V KG + K + A+K++ ++ + E N++++ + I Sbjct: 30 EVVGNGTYGQVYKGRHV--KTGQLAAIKVMDVTEDEEEE---IKLEINMLKKYSHHRNIA 84 Query: 434 RMIGIC-------EAESWMLVMEMAELGPLNKYLQQNRH--VKDKNIIELVHQVSMGMKY 484 G + LVME G + ++ + +K+ I + ++ G+ + Sbjct: 85 TYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAH 144 Query: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 L + +HRD+ +NVLL K+ DFG+S L D + T P W APE I Sbjct: 145 LHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQL--DRTVGRRNTFIGTPY-WMAPEVI 201 Query: 545 N-----YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGC-PAGCP 598 + +SD+WS G+ E + G P M ++ + Sbjct: 202 ACDENPDATYDYRSDLWSCGITAIEM-AEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWS 260 Query: 599 REMYDLMNLCWTYDVENRPGFAAVELR 625 ++ + + C + RP + Sbjct: 261 KKFFSFIEGCLVKNYMQRPSTEQLLKH 287 >5LPZ-A nrPDB Length = 332 Score = 192 bits (489), Expect = 3e-49, Method: Composition-based stats. Identities = 59/279 (21%), Positives = 118/279 (42%), Gaps = 31/279 (11%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 D +GSG FG V K + VA+K L + + E +AE + ++ + +V Sbjct: 22 DSLIGSGGFGDVYKAILKD---GSAVAIKKLIHVSGQGD--REFMAEMETIGKIKHRNLV 76 Query: 434 RMIGICE-AESWMLVMEMAELGPLNKYLQQNRH----VKDKNIIELVHQVSMGMKYLEES 488 ++G C+ + +LV E + G L L + + ++ + G+ +L + Sbjct: 77 PLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHN 136 Query: 489 ---NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 + +HRD+ + NVLL A++SDFG+++ + A + + T P + PE Sbjct: 137 CSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTP-GYVPPEYYQ 195 Query: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPY--RGMKGSEVTAMLEKGERMGCPAGCPREM-- 601 ++ S+K DV+S+GV++ E + G++P + + +++ ++ E+ Sbjct: 196 SFRCSTKGDVYSYGVVLLELLT-GKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPELMK 254 Query: 602 ------YDLMNL------CWTYDVENRPGFAAVELRLRN 628 +L+ C RP V + Sbjct: 255 EDPALEIELLQHLKVAVACLDDRAWRRPTMVQVMAMFKE 293 >6CTH-A nrPDB Length = 309 Score = 192 bits (488), Expect = 4e-49, Method: Composition-based stats. Identities = 70/275 (25%), Positives = 122/275 (44%), Gaps = 27/275 (9%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 + +LG G FG+V +G+ + +AVK + E +E ++ +L + +V Sbjct: 20 ENKLGEGGFGSVYRGFLRDSDT--YIAVKKVSRA--SKQGIKEYASEVKIISRLRHKNLV 75 Query: 434 RMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHV-KDKNIIELVHQVSMGMKYLEESN-- 489 ++IG C E MLV E G L+ ++ + + + + +V ++ + YL E Sbjct: 76 KLIGWCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHEEGDH 135 Query: 490 -FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYK 548 +HRD+ N++L + AK+ DFGL++ + D +T V + APEC++ K Sbjct: 136 CVLHRDIKTSNIMLDSSFNAKLGDFGLARLV--DHAKGLKKTLLAGTVGYMAPECLSSGK 193 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK------GERMGCPAGC----- 597 S +SDV+SFGV+ E S + + SE ++ ER+ A Sbjct: 194 ASKESDVYSFGVVALEIASGRRSIEPKFEESEALLLVPWVWESYGNERILDIADRKLGMA 253 Query: 598 --PREMYDL-MNLCWTYDVEN--RPGFAAVELRLR 627 P+++ L M W + RP V L Sbjct: 254 FDPKQLECLVMVGLWCAHPSHNLRPSIRQVIQVLN 288 >5LPV-A nrPDB Length = 296 Score = 192 bits (488), Expect = 4e-49, Method: Composition-based stats. Identities = 59/279 (21%), Positives = 118/279 (42%), Gaps = 31/279 (11%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 D +GSG FG V K + VA+K L + + E +AE + ++ + +V Sbjct: 22 DSLIGSGGFGDVYKAILKD---GSAVAIKKLIHVSGQGD--REFMAEMETIGKIKHRNLV 76 Query: 434 RMIGICE-AESWMLVMEMAELGPLNKYLQQNRH----VKDKNIIELVHQVSMGMKYLEES 488 ++G C+ + +LV E + G L L + + ++ + G+ +L + Sbjct: 77 PLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHN 136 Query: 489 ---NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 + +HRD+ + NVLL A++SDFG+++ + A + + T P + PE Sbjct: 137 CSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTP-GYVPPEYYQ 195 Query: 546 YYKFSSKSDVWSFGVLMWEAFSYGQKPY--RGMKGSEVTAMLEKGERMGCPAGCPREM-- 601 ++ S+K DV+S+GV++ E + G++P + + +++ ++ E+ Sbjct: 196 SFRCSTKGDVYSYGVVLLELLT-GKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPELMK 254 Query: 602 ------YDLMNL------CWTYDVENRPGFAAVELRLRN 628 +L+ C RP V + Sbjct: 255 EDPALEIELLQHLKVAVACLDDRAWRRPTMVQVMAMFKE 293 >4X3F-A nrPDB Length = 337 Score = 190 bits (484), Expect = 1e-48, Method: Composition-based stats. Identities = 64/249 (25%), Positives = 116/249 (46%), Gaps = 12/249 (4%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNE-ANDPALKDELLAEANVMQQLDNPYIV 433 + + +G G V + ++ + VAVK+LK+E ++DP + AEA L++P I Sbjct: 18 RLIATGGMGQVWEAVDN--RLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIA 75 Query: 434 RMIGICEAE------SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 487 + E++ + LVME+ PLN L++ + ++ ++++ Q ++ Sbjct: 76 SVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHA 135 Query: 488 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY 547 + VHRD+ N+L+ KI+DFG++KA+ D ++ APE + Sbjct: 136 AGLVHRDVKPGNILITPTGQVKITDFGIAKAV--DAAPVTQTGMVMGTAQYIAPEQALGH 193 Query: 548 KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNL 607 S SDV+S GV+ +EA S G++P+ G V K P P + +L+ + Sbjct: 194 DASPASDVYSLGVVGYEAVS-GKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVRELIEI 252 Query: 608 CWTYDVENR 616 + R Sbjct: 253 TLVKNPAMR 261 >4OW8-A nrPDB Length = 283 Score = 190 bits (484), Expect = 1e-48, Method: Composition-based stats. Identities = 64/249 (25%), Positives = 116/249 (46%), Gaps = 12/249 (4%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNE-ANDPALKDELLAEANVMQQLDNPYIV 433 + + +G G V + ++ + VAVK+LK+E ++DP + AEA L++P I Sbjct: 17 RLIATGGMGQVWEAVDN--RLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIA 74 Query: 434 RMIGICEAE------SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 487 + E++ + LVME+ PLN L++ + ++ ++++ Q ++ Sbjct: 75 SVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHA 134 Query: 488 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY 547 + VHRD+ N+L+ KI+DFG++KA+ D ++ APE + Sbjct: 135 AGLVHRDVKPGNILITPTGQVKITDFGIAKAV--DAAPVTQTGMVMGTAQYIAPEQALGH 192 Query: 548 KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNL 607 S SDV+S GV+ +EA S G++P+ G V K P P + +L+ + Sbjct: 193 DASPASDVYSLGVVGYEAVS-GKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVRELIEI 251 Query: 608 CWTYDVENR 616 + R Sbjct: 252 TLVKNPAMR 260 >4RT7-A nrPDB Length = 415 Score = 190 bits (483), Expect = 1e-48, Method: Composition-based stats. Identities = 70/210 (33%), Positives = 110/210 (52%), Gaps = 9/210 (4%) Query: 419 AEANVMQQLDNPYIVRMIG-ICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQ 477 E + D+ I + G +E + E L + N + ++++ +Q Sbjct: 198 REVQI--HPDSDQISGLHGNSFHSEDEI---EYENQKRLEEEEDLN-VLTFEDLLCFAYQ 251 Query: 478 VSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVK 537 V+ GM++LE + VHRDLAARNVL+ KI DFGL++ + +D N Y + + + PVK Sbjct: 252 VAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSN-YVVRGNARLPVK 310 Query: 538 WYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMK-GSEVTAMLEKGERMGCPAG 596 W APE + ++ KSDVWS+G+L+WE FS G PY G+ + +++ G +M P Sbjct: 311 WMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFY 370 Query: 597 CPREMYDLMNLCWTYDVENRPGFAAVELRL 626 E+Y +M CW +D RP F + L Sbjct: 371 ATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 400 Score = 97.8 bits (242), Expect = 1e-20, Method: Composition-based stats. Identities = 36/108 (33%), Positives = 53/108 (49%), Gaps = 7/108 (6%) Query: 362 EVYLDRKLLTLEDKELGSGNFGTVKKGY-YQMKKVV--KTVAVKILKNEANDPALKDELL 418 + R+ L K LGSG FG V Y + K VAVK+LK +A D + ++ L+ Sbjct: 59 KWEFPRENLEF-GKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKA-DSSEREALM 116 Query: 419 AEANVMQQL-DNPYIVRMIGICE-AESWMLVMEMAELGPLNKYLQQNR 464 +E +M QL + IV ++G C + L+ E G L YL+ R Sbjct: 117 SELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKR 164 >5AR8-A nrPDB Length = 326 Score = 190 bits (483), Expect = 1e-48, Method: Composition-based stats. Identities = 65/273 (23%), Positives = 120/273 (43%), Gaps = 23/273 (8%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILK-NEANDPALKDELLAEANVMQQLDNPYIV 433 + L G GTV + +V VAVK L + + + ++L EA ++ + YI+ Sbjct: 38 RYLSRGASGTVSSARHADWRV--QVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYIL 95 Query: 434 RMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKD---KNIIELVHQVSMGMKYLEESN 489 ++GIC ++ +V E G LN+ L + D ++H++++G+ YL Sbjct: 96 PILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMT 155 Query: 490 --FVHRDLAARNVLLVTQHYAKISDFGLS--KALRADENYYKAQTHGKWPVKWYAPECI- 544 +H DL +N+LL + + KI+DFGLS + + ++ + + PE Sbjct: 156 PPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYE 215 Query: 545 --NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGS-EVTAMLEKGERM-----GCPAG 596 + S K D++S+ V+ WE S ++P+ + ++ + +G R P Sbjct: 216 PGQKSRASIKHDIYSYAVITWEVLSR-KQPFEDVTNPLQIMYSVSQGHRPVINEESLPYD 274 Query: 597 CP--REMYDLMNLCWTYDVENRPGFAAVELRLR 627 P M L+ W + + RP F + L Sbjct: 275 IPHRARMISLIESGWAQNPDERPSFLKCLIELE 307 >6B2Q-A nrPDB Length = 317 Score = 190 bits (483), Expect = 1e-48, Method: Composition-based stats. Identities = 64/249 (25%), Positives = 116/249 (46%), Gaps = 12/249 (4%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNE-ANDPALKDELLAEANVMQQLDNPYIV 433 + + +G G V + ++ + VAVK+LK+E ++DP + AEA L++P I Sbjct: 38 RLIATGGMGQVWEAVDN--RLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIA 95 Query: 434 RMIGICEAE------SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 487 + E++ + LVME+ PLN L++ + ++ ++++ Q ++ Sbjct: 96 SVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHA 155 Query: 488 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY 547 + VHRD+ N+L+ KI+DFG++KA+ D ++ APE + Sbjct: 156 AGLVHRDVKPGNILITPTGQVKITDFGIAKAV--DAAPVTQTGMVMGTAQYIAPEQALGH 213 Query: 548 KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNL 607 S SDV+S GV+ +EA S G++P+ G V K P P + +L+ + Sbjct: 214 DASPASDVYSLGVVGYEAVS-GKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVRELIEI 272 Query: 608 CWTYDVENR 616 + R Sbjct: 273 TLVKNPAMR 281 >3N9X-A nrPDB Length = 432 Score = 190 bits (482), Expect = 2e-48, Method: Composition-based stats. Identities = 50/216 (23%), Positives = 95/216 (43%), Gaps = 29/216 (13%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G G++G V Y K K VA+K + D +L E ++ +L + YI+R+ Sbjct: 34 IGRGSYGYVYLAYD--KNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDYIIRLY 91 Query: 437 GICEAESW------MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 + + +V+E+A+ L K + + +++I +++ + +G ++ ES Sbjct: 92 DLIIPDDLLKFDELYIVLEIAD-SDLKKLFKTPIFLTEEHIKTILYNLLLGENFIHESGI 150 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENY------------------YKAQTHG 532 +HRDL N LL K+ DFGL++ + ++++ K Q Sbjct: 151 IHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKNLKKQLTS 210 Query: 533 KWPVKWY-APE-CINYYKFSSKSDVWSFGVLMWEAF 566 +WY APE + ++ D+WS G + E Sbjct: 211 HVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELL 246 >3NIE-A nrPDB Length = 429 Score = 188 bits (477), Expect = 7e-48, Method: Composition-based stats. Identities = 51/219 (23%), Positives = 96/219 (43%), Gaps = 32/219 (14%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G G++G V Y K K VA+K + D +L E ++ +L + YI+R+ Sbjct: 36 IGRGSYGYVYLAYD--KNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDYIIRLH 93 Query: 437 GICEAESW------MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 + E +V+E+A+ L K + + ++++ +++ + +G K++ ES Sbjct: 94 DLIIPEDLLKFDELYIVLEIAD-SDLKKLFKTPIFLTEQHVKTILYNLLLGEKFIHESGI 152 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYY----------------------KA 528 +HRDL N LL KI DFGL++ + +D++ + K Sbjct: 153 IHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPHNKNLKKQ 212 Query: 529 QTHGKWPVKWYAPE-CINYYKFSSKSDVWSFGVLMWEAF 566 T + APE + +++ D+WS G + E Sbjct: 213 LTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELL 251 >2I6L-A nrPDB Length = 320 Score = 187 bits (476), Expect = 8e-48, Method: Composition-based stats. Identities = 62/310 (20%), Positives = 114/310 (36%), Gaps = 56/310 (18%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPY 431 ++ K LG G G V K VA+K + DP L E ++++LD+ Sbjct: 14 MDLKPLGCGGNGLVFSAVDN--DCDKRVAIKKI--VLTDPQSVKHALREIKIIRRLDHDN 69 Query: 432 IVRMIGIC---------------EAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVH 476 IV++ I E S +V E E L L + + +++ ++ Sbjct: 70 IVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMET-DLANVL-EQGPLLEEHARLFMY 127 Query: 477 QVSMGMKYLEESNFVHRDLAARNVLLV-TQHYAKISDFGLSKALRADENYYKAQTHGKWP 535 Q+ G+KY+ +N +HRDL N+ + KI DFGL++ + ++ + G Sbjct: 128 QLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVT 187 Query: 536 VKWYAPECINY-YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK------- 587 + +P + ++ D+W+ G + E + G+ + G E ++ + Sbjct: 188 KWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLT-GKTLFAGAHELEQMQLILESIPVVHE 246 Query: 588 --------------GERMGCP--------AGCPREMYDLMNLCWTYDVENRPGFAAVELR 625 M P G RE D + T+ +R E Sbjct: 247 EDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTA---EEA 303 Query: 626 LRNYYYDVVN 635 L + Y + + Sbjct: 304 LSHPYMSIYS 313 >2QKW-B nrPDB Length = 321 Score = 187 bits (474), Expect = 2e-47, Method: Composition-based stats. Identities = 71/302 (23%), Positives = 118/302 (39%), Gaps = 35/302 (11%) Query: 346 EVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILK 405 E Y P D EE D K L +G G FG V KG + VA+K Sbjct: 25 ESYRVPLVDLEEATNN---FDHKFL------IGHGVFGKVYKGVLRD---GAKVALKRRT 72 Query: 406 NEANDPALKDELLAEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQN- 463 E++ + E + +P++V +IG C E +L+ + E G L ++L + Sbjct: 73 PESSQGIEEFETEI--ETLSFCRHPHLVSLIGFCDERNEMILIYKYMENGNLKRHLYGSD 130 Query: 464 ---RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALR 520 + + +E+ + G+ YL +HRD+ + N+LL KI+DFG+SK Sbjct: 131 LPTMSMSWEQRLEICIGAARGLHYLHTRAIIHRDVKSINILLDENFVPKITDFGISKK-G 189 Query: 521 ADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYG-----QKP--- 572 + + T K + + PE + + KSDV+SFGV+++E P Sbjct: 190 TELDQTHLSTVVKGTLGYIDPEYFIKGRLTEKSDVYSFGVVLFEVLCARSAIVQSLPREM 249 Query: 573 -------YRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELR 625 ++ +++ R+ D C E+RP V + Sbjct: 250 VNLAEWAVESHNNGQLEQIVDPNLADKIRPESLRKFGDTAVKCLALSSEDRPSMGDVLWK 309 Query: 626 LR 627 L Sbjct: 310 LE 311 >3MDY-A nrPDB Length = 337 Score = 186 bits (473), Expect = 2e-47, Method: Composition-based stats. Identities = 65/293 (22%), Positives = 122/293 (41%), Gaps = 50/293 (17%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K++G G +G V G ++ + VAVK+ ++ + + +M+ + I+ Sbjct: 43 KQIGKGRYGEVWMGKWR----GEKVAVKVFFTTEEASWFRETEIYQTVLMR---HENILG 95 Query: 435 MI--GICEAESW---MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE--- 486 I I SW L+ + E G L YL+ + K++++L + G+ +L Sbjct: 96 FIAADIKGTGSWTQLYLITDYHENGSLYDYLKST-TLDAKSMLKLAYSSVSGLCHLHTEI 154 Query: 487 -----ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPV-KWYA 540 + HRDL ++N+L+ I+D GL+ +D N + + ++ Sbjct: 155 FSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMP 214 Query: 541 PECI-------NYYKFSSKSDVWSFGVLMWE----AFSYG-----QKPYRGMKGSEVTA- 583 PE + ++ + +D++SFG+++WE S G Q PY + S+ + Sbjct: 215 PEVLDESLNRNHFQSY-IMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYE 273 Query: 584 -----MLEKGERMGCP-----AGCPREMYDLMNLCWTYDVENRPGFAAVELRL 626 + K R P C R+M LM CW ++ +R V+ L Sbjct: 274 DMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTL 326 >2RIO-A nrPDB Length = 434 Score = 185 bits (469), Expect = 6e-47, Method: Composition-based stats. Identities = 67/293 (22%), Positives = 123/293 (41%), Gaps = 45/293 (15%) Query: 368 KLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL 427 K L + +K LG G+ GTV +Q + VAVK + + D A L E ++ + Sbjct: 14 KNLVVSEKILGYGSSGTV---VFQGSFQGRPVAVKRMLIDFCDIA-----LMEIKLLTES 65 Query: 428 D-NPYIVRMIGICEAESWMLV-MEMAELGPLNKYLQQNRHVKDKNI--------IELVHQ 477 D +P ++R + ++ + +E+ L L L ++++V D+N+ I L+ Q Sbjct: 66 DDHPNVIRYYCSETTDRFLYIALELCNL-NLQD-LVESKNVSDENLKLQKEYNPISLLRQ 123 Query: 478 VSMGMKYLEESNFVHRDLAARNVLLV-------------TQHYAKISDFGLSKALRADEN 524 ++ G+ +L +HRDL +N+L+ ISDFGL K L + ++ Sbjct: 124 IASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQS 183 Query: 525 YYKAQTHGK-WPVKWYAPECINY-------YKFSSKSDVWSFGVLMWEAFSYGQKPYRG- 575 ++ + W APE + + + D++S G + + S G+ P+ Sbjct: 184 SFRTNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDK 243 Query: 576 -MKGSEVTAMLEKGERMGC--PAGCPREMYDLMNLCWTYDVENRPGFAAVELR 625 + S + + + M C E DL++ +D RP V Sbjct: 244 YSRESNIIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRH 296 >4E7W-A nrPDB Length = 394 Score = 184 bits (467), Expect = 1e-46, Method: Composition-based stats. Identities = 64/327 (19%), Positives = 115/327 (35%), Gaps = 65/327 (19%) Query: 351 PYADPEEI-----RPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILK 405 P DP ++ + R++ K +G+G+FG V + VA+K + Sbjct: 17 PLDDPNKVIKVLASDGKTGEQREIAYTNCKVIGNGSFGVVFQAKLVESD---EVAIKKV- 72 Query: 406 NEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAES-------WMLVMEMAE---LGP 455 D K+ E +M+ + +P +V + + LV+E Sbjct: 73 --LQDKRFKN---RELQIMRIVKHPNVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRA 127 Query: 456 LNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV-TQHYAKISDFG 514 Y + + + I ++Q+ + Y+ HRD+ +N+LL K+ DFG Sbjct: 128 SRHYAKLKQTMPMLLIKLYMYQLLRSLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFG 187 Query: 515 LSKALRADENYYKAQTHGKWPVKWYAPECINY-YKFSSKSDVWSFGVLMWEAFSYGQKPY 573 +K L A E + APE I +++ D+WS G +M E GQ + Sbjct: 188 SAKILIAGEP----NVSYICSRYYRAPELIFGATNYTTNIDIWSTGCVMAELM-QGQPLF 242 Query: 574 RGMKGSEVTAMLEKGERMGCP------------------------------AGCPREMYD 603 G G + ++E + +G P P + D Sbjct: 243 PGESG--IDQLVEIIKVLGTPSREQIKTMNPNYMEHKFPQIRPHPFSKVFRPRTPPDAID 300 Query: 604 LMNLCWTYDVENRPGFAAVELRLRNYY 630 L++ Y R A+E ++ Sbjct: 301 LISRLLEYTPSARLT--AIEALCHPFF 325 >5AIR-A nrPDB Length = 430 Score = 184 bits (467), Expect = 1e-46, Method: Composition-based stats. Identities = 65/263 (24%), Positives = 111/263 (42%), Gaps = 37/263 (14%) Query: 345 TEVYESPYADPEEIRPKEV-YLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKI 403 T V +P P+ RP+EV Y D K +G+G+FG V + ++ + VA+K Sbjct: 48 TTVVATPGQGPD--RPQEVSYTDT-------KVIGNGSFGVVYQA--KLCDSGELVAIKK 96 Query: 404 LKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC-----EAESWML--VMEMAE---L 453 + D K+ E +M++LD+ IVR+ + + L V++ Sbjct: 97 V---LQDKRFKN---RELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVY 150 Query: 454 GPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA-KISD 512 Y + + + + ++Q+ + Y+ HRD+ +N+LL K+ D Sbjct: 151 RVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCD 210 Query: 513 FGLSKALRADENYYKAQTHGKWPVKWYAPECINY-YKFSSKSDVWSFGVLMWEAFSYGQK 571 FG +K L E + APE I ++S DVWS G ++ E GQ Sbjct: 211 FGSAKQLVRGEP----NVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELL-LGQP 265 Query: 572 PYRGMKGSEVTAMLEKGERMGCP 594 + G G V ++E + +G P Sbjct: 266 IFPGDSG--VDQLVEIIKVLGTP 286 >5VD3-A nrPDB Length = 311 Score = 184 bits (466), Expect = 1e-46, Method: Composition-based stats. Identities = 59/292 (20%), Positives = 113/292 (38%), Gaps = 20/292 (6%) Query: 336 PQREALPMD-TEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKK 394 P+R + + +E +SP DP E + + L LG G++G V K + K+ Sbjct: 28 PRRVSFRGEASETLQSPGYDPSRP---ESFFQQSFQRLS--RLGHGSYGEVFK--VRSKE 80 Query: 395 VVKTVAVKILKNEANDPALKDELLAEANVMQQL-DNPYIVRMIGICEAES-WMLVMEMAE 452 + AVK + P + LAE +++ +P VR+ E L E+ Sbjct: 81 DGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELC- 139 Query: 453 LGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKIS 511 L ++ + + + + + + + +L VH D+ N+ L + K+ Sbjct: 140 GPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLG 199 Query: 512 DFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQK 571 DFGL L A + ++ APE + + + +DV+S G+ + E + Sbjct: 200 DFGLLVEL----GTAGAGEVQEGDPRYMAPELLQG-SYGTAADVFSLGLTILEVACNMEL 254 Query: 572 PYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVE 623 P+ G ++ AG E+ ++ + D + R A+ Sbjct: 255 PHGGEGWQQLRQGY---LPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALL 303 >4H1O-A nrPDB Length = 560 Score = 184 bits (466), Expect = 1e-46, Method: Composition-based stats. Identities = 68/276 (24%), Positives = 101/276 (36%), Gaps = 74/276 (26%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74 +F NIT EAE+ L+ G DG +L R S++ G F LSV H I+ G Y Sbjct: 27 WFHPNITGVEAENLLLTRG-VDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQN-TGGYY 84 Query: 75 AIAGGRTHASPADLCHYHS------QESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLI 128 + GG A+ A+L Y+ +E +G V LK P N Sbjct: 85 DLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLN-------------------- 124 Query: 129 REYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKT 188 P E+ WFHG +S +E+E+++ K Sbjct: 125 --------------------CADPTSER-----------WFHGHLSGKEAEKLLTEKGK- 152 Query: 189 NGKFLIRAR-DNNGSYALCLLHEG----------KVLHYRIDKDKTGKLSIPEGKKFDTL 237 +G FL+R + G + L + KV H I + + K + G++FD+L Sbjct: 153 HGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMI-RCQELKYDVGGGERFDSL 211 Query: 238 WQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGR 273 LVEHY ++ L Q Sbjct: 212 TDLVEHYKKNP--MVETLGTVLQLKQPLNTTRINAA 245 Score = 110 bits (275), Expect = 2e-24, Method: Composition-based stats. Identities = 42/155 (27%), Positives = 69/155 (44%), Gaps = 19/155 (12%) Query: 7 ADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGR------- 59 AD + +F G+++ +EAE L + G G +L+R+S+++ G F LSV G Sbjct: 126 ADPTS-ERWFHGHLSGKEAEKLLTEKG-KHGSFLVRESQSHPGDFVLSVRTGDDKGESND 183 Query: 60 ---KAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQES----DGLVCLLKKPFN--RP 110 K H I + Y + GG S DL ++ + G V LK+P N R Sbjct: 184 GKSKVTHVMIRCQ-ELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRI 242 Query: 111 QGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQ 145 + ++ E K + VKQ + + + L+Q Sbjct: 243 NAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQ 277 >4M66-A nrPDB Length = 325 Score = 183 bits (465), Expect = 2e-46, Method: Composition-based stats. Identities = 75/287 (26%), Positives = 119/287 (41%), Gaps = 34/287 (11%) Query: 373 EDKEL---GSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDN 429 E K+L G G FG V + +++ VAVKI+ ++ ++ E M L N Sbjct: 21 ELKKLEFVGKGGFGVVFRAHHRTWN--HDVAVKIVNSK--------KISWEVKAMVNLRN 70 Query: 430 PYIVRMIGICEAESW------MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMK 483 ++ ++G+ E W LV E G L LQ + L+ +V +GM Sbjct: 71 ENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGMC 130 Query: 484 YLEESN--FVHRDLAARNVLLVTQHYAKISDFGLSK---ALRADENYYKAQTHGKWPVKW 538 YL + +HRDL N+LL + +AK++DFGLS ++ + + Sbjct: 131 YLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAY 190 Query: 539 YAPECINY--YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMG---C 593 PE + K S SDV+SFG+L+W + + + ++ R Sbjct: 191 LDPELLFKVNLKASKASDVYSFGILVWAVLAGREAELVDKTSLIRETVCDRQSRPPLTEL 250 Query: 594 PAGCP-----REMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 P G P ++ +LM CW ENRP F E + Y V + Sbjct: 251 PPGSPETPGLEKLKELMIHCWGSQSENRPSFQDCEPKTNEVYNLVKD 297 >5USZ-A nrPDB Length = 289 Score = 183 bits (465), Expect = 2e-46, Method: Composition-based stats. Identities = 68/275 (24%), Positives = 127/275 (46%), Gaps = 27/275 (9%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKV-----VKTVAVKILKNEANDPALKDELLAEANVMQQ 426 + ++ LG G F + KG + V +K+L + + A++M + Sbjct: 11 IFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRN--YSESFFEAASMMSK 68 Query: 427 LDNPYIVRMIGICE-AESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKY 484 L + ++V G+C + +LV E + G L+ YL++N++ + +E+ Q++ M + Sbjct: 69 LSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAAAMHF 128 Query: 485 LEESNFVHRDLAARNVLLVTQHY--------AKISDFGLSKALRADENYYKAQTHGKWPV 536 LEE+ +H ++ A+N+LL+ + K+SD G+S + + + + Sbjct: 129 LEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQER-------I 181 Query: 537 KWYAPECI-NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPA 595 W PECI N + +D WSFG +WE S G KP + E ++ P Sbjct: 182 PWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPK 241 Query: 596 GCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYY 630 E+ +L+N C Y+ ++RP F A+ L + + Sbjct: 242 A--AELANLINNCMDYEPDHRPSFRAIIRDLNSLF 274 >1TKI-A nrPDB Length = 321 Score = 182 bits (462), Expect = 4e-46, Method: Composition-based stats. Identities = 57/270 (21%), Positives = 111/270 (41%), Gaps = 19/270 (7%) Query: 363 VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEAN 422 L K + ED LG G FG V + K KT K +K + D L + E + Sbjct: 1 KELYEKYMIAED--LGRGEFGIVHRCVETSSK--KTYMAKFVKVKGTDQVL---VKKEIS 53 Query: 423 VMQQLDNPYIVRMIGICEA-ESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSM 480 ++ + I+ + E+ E +++ E + + + + + ++ I+ VHQV Sbjct: 54 ILNIARHRNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCE 113 Query: 481 GMKYLEESNFVHRDLAARNVLLVTQH--YAKISDFGLSKALRADENYYKAQTHGKWPVKW 538 +++L N H D+ N++ T+ KI +FG ++ L+ +N+ T ++ Sbjct: 114 ALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTA----PEY 169 Query: 539 YAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPA--- 595 YAPE + S+ +D+WS G L++ S G P+ ++ + E Sbjct: 170 YAPEVHQHDVVSTATDMWSLGTLVYVLLS-GINPFLAETNQQIIENIMNAEYTFDEEAFK 228 Query: 596 GCPREMYDLMNLCWTYDVENRPGFAAVELR 625 E D ++ + ++R + Sbjct: 229 EISIEAMDFVDRLLVKERKSRMTASEALQH 258 >3RP9-A nrPDB Length = 458 Score = 182 bits (462), Expect = 4e-46, Method: Composition-based stats. Identities = 55/263 (20%), Positives = 110/263 (41%), Gaps = 51/263 (19%) Query: 335 GPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKK 394 ++P ++ P DR + +G+G++G V + Y +++K Sbjct: 36 SKPTASMPRPHSDWQIP--------------DRYEIRHL---IGTGSYGHVCEAYDKLEK 78 Query: 395 VVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEA------ESWMLVM 448 + VA+K + D +L E ++ +L++ ++V+++ I + +V+ Sbjct: 79 --RVVAIKKILRVFEDLIDCKRILREIAILNRLNHDHVVKVLDIVIPKDVEKFDELYVVL 136 Query: 449 EMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYA 508 E+A+ K + ++ + +I L++ + +G+KY+ + +HRDL N L+ Sbjct: 137 EIAD-SDFKKLFRTPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSV 195 Query: 509 KISDFGLSKALRADEN-----------------------YYKAQTHGKWPVKWY-APE-C 543 K+ DFGL++ + EN K Q G +WY APE Sbjct: 196 KVCDFGLARTVDYPENGNSQLPISPREDDMNLVTFPHTKNLKRQLTGHVVTRWYRAPELI 255 Query: 544 INYYKFSSKSDVWSFGVLMWEAF 566 + ++ DVWS G + E Sbjct: 256 LLQENYTEAIDVWSIGCIFAELL 278 >4X7Q-B nrPDB Length = 312 Score = 182 bits (462), Expect = 4e-46, Method: Composition-based stats. Identities = 64/275 (23%), Positives = 113/275 (41%), Gaps = 30/275 (10%) Query: 366 DRKLLTLEDKE---LGSGNFGTVKKGYYQMKKVVKTVAVKILKNE--------ANDPALK 414 DR+ E + LG G FGTV G+ ++ VA+K++ ++ Sbjct: 25 DREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRL--QVAIKVIPRNRVLGWSPLSDSVTCP 82 Query: 415 DELLAEANVMQQLDNPYIVRMIGICEA-ESWMLVMEM-AELGPLNKYLQQNRHVKDKNII 472 E+ V +P ++R++ E E +MLV+E L Y+ + + + Sbjct: 83 LEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSR 142 Query: 473 ELVHQVSMGMKYLEESNFVHRDLAARNVLLV-TQHYAKISDFGLSKALRADENYYKAQTH 531 QV +++ VHRD+ N+L+ + AK+ DFG S AL DE Y T Sbjct: 143 CFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFG-SGALLHDEPY----TD 197 Query: 532 GKWPVKWYAPECINYYKFSS-KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGER 590 + PE I+ +++ + + VWS G+L+++ G P+ + E+ Sbjct: 198 FDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVC-GDIPFE--RDQEILEA-----E 249 Query: 591 MGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELR 625 + PA + L+ C +RP + L Sbjct: 250 LHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLD 284 >3Q4U-A nrPDB Length = 301 Score = 182 bits (461), Expect = 5e-46, Method: Composition-based stats. Identities = 57/291 (19%), Positives = 109/291 (37%), Gaps = 50/291 (17%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G G +G V +G +Q + VAVKI + ++ E L + I+ I Sbjct: 16 VGKGRYGEVWRGSWQ----GENVAVKIFSSRDEKSWFRET---ELYNTVMLRHENILGFI 68 Query: 437 GI-----CEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE----- 486 + L+ E+G L YLQ + + + +V ++ G+ +L Sbjct: 69 ASDMTSRHSSTQLWLITHYHEMGSLYDYLQLT-TLDTVSCLRIVLSIASGLAHLHIEIFG 127 Query: 487 ---ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPV-KWYAPE 542 + HRDL ++N+L+ I+D GL+ N + + ++ APE Sbjct: 128 TQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPE 187 Query: 543 CINYY-------KFSSKSDVWSFGVLMWE----AFSYG-----QKPYRGMKGS----EVT 582 ++ + + D+W+FG+++WE S G + P+ + + E Sbjct: 188 VLDETIQVDCFDSY-KRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDM 246 Query: 583 AML--EKGERMGCPAGCPRE-----MYDLMNLCWTYDVENRPGFAAVELRL 626 + +R P + + LM CW + R ++ L Sbjct: 247 RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTL 297 >3BGP-A nrPDB Length = 333 Score = 180 bits (457), Expect = 1e-45, Method: Composition-based stats. Identities = 50/257 (19%), Positives = 109/257 (42%), Gaps = 25/257 (9%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALK----DELLAEANVMQQLDNPY- 431 LGSG FG+V G + VA+K ++ + + + E +++++ + + Sbjct: 64 LGSGGFGSVYSGIRVSDNL--PVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFS 121 Query: 432 -IVRMIGICE-AESWMLVMEM-AELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 ++R++ E +S++L++E + L ++ + ++++ QV +++ Sbjct: 122 GVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNC 181 Query: 489 NFVHRDLAARNVLLV-TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY 547 +HRD+ N+L+ + K+ DFG L+ T + PE I Y+ Sbjct: 182 GVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-----TVYTDFDGTRVYSPPEWIRYH 236 Query: 548 KF-SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMN 606 ++ + VWS G+L+++ G P+ E + +G+ E L+ Sbjct: 237 RYHGRSAAVWSLGILLYDMVC-GDIPF------EHDEEIIRGQVF-FRQRVSSECQHLIR 288 Query: 607 LCWTYDVENRPGFAAVE 623 C +RP F ++ Sbjct: 289 WCLALRPSDRPTFEEIQ 305 >4G3E-A nrPDB Length = 352 Score = 180 bits (457), Expect = 1e-45, Method: Composition-based stats. Identities = 62/307 (20%), Positives = 113/307 (36%), Gaps = 18/307 (5%) Query: 326 ELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEV-YLDRKLLTLEDKELGSGNFGT 384 LA + + + L +TE E E+++P + Y + +G G+FG Sbjct: 31 SLAKTWSSGSAKLQRLGPETEDNEGVLLT-EKLKPVDYEYREEVHWMTHQPRVGRGSFGE 89 Query: 385 VKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESW 444 V + + K+ AVK ++ E + E L +P IV + G W Sbjct: 90 VHR--MKDKQTGFQCAVKKVRLEVFR-------VEELVACAGLSSPRIVPLYGAVREGPW 140 Query: 445 M-LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV 503 + + ME+ E G L + ++Q + + + + Q G++YL +H D+ A NVLL Sbjct: 141 VNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVKADNVLLS 200 Query: 504 TQH-YAKISDFGLSKALRAD--ENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGV 560 + A + DFG + L+ D + APE + +K D+WS Sbjct: 201 SDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCDAKVDIWSSCC 260 Query: 561 LMWEAFSYGQKPYRGMKGSEVTAMLEK--GERMGCPAGCPREMYDLMNLCWTYDVENRPG 618 +M + G P+ + + P C + + +R Sbjct: 261 MMLHMLN-GCHPWTQYFRGPLCLKIASEPPPIREIPPSCAPLTAQAIQEGLRKEPVHRAS 319 Query: 619 FAAVELR 625 + + Sbjct: 320 AMELRRK 326 >4RC3-A nrPDB Length = 289 Score = 179 bits (455), Expect = 3e-45, Method: Composition-based stats. Identities = 50/257 (19%), Positives = 109/257 (42%), Gaps = 25/257 (9%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALK----DELLAEANVMQQLDNPY- 431 LGSG FG+V G + VA+K ++ + + + E +++++ + + Sbjct: 20 LGSGGFGSVYSGIRVSDNL--PVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFS 77 Query: 432 -IVRMIGICE-AESWMLVMEM-AELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 ++R++ E +S++L++E + L ++ + ++++ QV +++ Sbjct: 78 GVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNC 137 Query: 489 NFVHRDLAARNVLLV-TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY 547 +HRD+ N+L+ + K+ DFG L+ T + PE I Y+ Sbjct: 138 GVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-----TVYTDFDGTRVYSPPEWIRYH 192 Query: 548 KF-SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMN 606 ++ + VWS G+L+++ G P+ E + +G+ E L+ Sbjct: 193 RYHGRSAAVWSLGILLYDMVC-GDIPF------EHDEEIIRGQVF-FRQRVSSECQHLIR 244 Query: 607 LCWTYDVENRPGFAAVE 623 C +RP F ++ Sbjct: 245 WCLALRPSDRPTFEEIQ 261 >5XD6-A nrPDB Length = 305 Score = 179 bits (454), Expect = 3e-45, Method: Composition-based stats. Identities = 68/284 (23%), Positives = 116/284 (40%), Gaps = 37/284 (13%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G G++G V G K K A+K L + E LA+ +++ +L +V ++ Sbjct: 30 IGEGSYGRVFYGIL---KSGKAAAIKKLD---SSKQPDQEFLAQVSMVSRLRQENVVALL 83 Query: 437 GIC-EAESWMLVMEMAELGPLNKYLQQNRH---------VKDKNIIELVHQVSMGMKYLE 486 G C + +L E A G L+ L + + +++ + G++YL Sbjct: 84 GYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAARGLEYLH 143 Query: 487 ES---NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPEC 543 E + +HRD+ + NVLL AKI+DF LS D T ++APE Sbjct: 144 EKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQ-APDMAARLHSTRVLGTFGYHAPEY 202 Query: 544 INYYKFSSKSDVWSFGVLMWEAFSYGQKP----------------YRGMKGSEVTAMLEK 587 S+KSDV+SFGV++ E + G+KP + +V ++ Sbjct: 203 AMTGTLSTKSDVYSFGVVLLELLT-GRKPVDHTLPRGQQSVVTWATPKLSEDKVKQCVDA 261 Query: 588 GERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYY 631 P ++ + LC Y+ + RP + V L+ Sbjct: 262 RLNGEYPPKAVAKLAAVAALCVQYEADFRPNMSIVVKALQPLLN 305 >5TUR-A nrPDB Length = 404 Score = 178 bits (452), Expect = 5e-45, Method: Composition-based stats. Identities = 50/257 (19%), Positives = 109/257 (42%), Gaps = 25/257 (9%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALK----DELLAEANVMQQLDNPY- 431 LGSG FG+V G + VA+K ++ + + + E +++++ + + Sbjct: 135 LGSGGFGSVYSGIRVSDNL--PVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFS 192 Query: 432 -IVRMIGICE-AESWMLVMEM-AELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 ++R++ E +S++L++E + L ++ + ++++ QV +++ Sbjct: 193 GVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNC 252 Query: 489 NFVHRDLAARNVLLV-TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY 547 +HRD+ N+L+ + K+ DFG L+ T + PE I Y+ Sbjct: 253 GVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-----TVYTDFDGTRVYSPPEWIRYH 307 Query: 548 KF-SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMN 606 ++ + VWS G+L+++ G P+ E + +G+ E L+ Sbjct: 308 RYHGRSAAVWSLGILLYDMVC-GDIPF------EHDEEIIRGQVF-FRQRVSSECQHLIR 359 Query: 607 LCWTYDVENRPGFAAVE 623 C +RP F ++ Sbjct: 360 WCLALRPSDRPTFEEIQ 376 >1PY5-A nrPDB Length = 326 Score = 178 bits (452), Expect = 6e-45, Method: Composition-based stats. Identities = 69/296 (23%), Positives = 115/296 (38%), Gaps = 48/296 (16%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPY 431 + + +G G FG V +G ++ + VAVKI + ++ AE L + Sbjct: 32 VLQESIGKGRFGEVWRGKWR----GEEVAVKIFSSREERSWFRE---AEIYQTVMLRHEN 84 Query: 432 IVRMIGICEAES-----WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE 486 I+ I ++ LV + E G L YL V + +I+L + G+ +L Sbjct: 85 ILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYL-NRYTVTVEGMIKLALSTASGLAHLH 143 Query: 487 --------ESNFVHRDLAARNVLLVTQHYAKISDFGLS-KALRADENYYKAQTHGKWPVK 537 + HRDL ++N+L+ I+D GL+ + A + A H + Sbjct: 144 MEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKR 203 Query: 538 WYAPEC----INYYKFS--SKSDVWSFGVLMWEA---FSYG------QKPYRGMKGSE-- 580 + APE IN F ++D+++ G++ WE S G Q PY + S+ Sbjct: 204 YMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPS 263 Query: 581 VTAM----LEKGERMGCPAGCP-----REMYDLMNLCWTYDVENRPGFAAVELRLR 627 V M E+ R P R M +M CW + R ++ L Sbjct: 264 VEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLS 319 >3PG1-A nrPDB Length = 362 Score = 178 bits (451), Expect = 8e-45, Method: Composition-based stats. Identities = 66/310 (21%), Positives = 116/310 (37%), Gaps = 64/310 (20%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPA---------LKDELLAEANVMQ 425 + + SG++G V G VA+K + N +D L +L E ++ Sbjct: 28 RFISSGSYGAVCAGVDSE---GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRLLN 84 Query: 426 QLDNPYIVRMIGICEA------ESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQV 478 +P I+ + I LV E+ L + + R + ++I ++ + Sbjct: 85 HFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRT-DLAQVIHDQRIVISPQHIQYFMYHI 143 Query: 479 SMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKW 538 +G+ L E+ VHRDL N+LL + I DF L++ AD N TH + Sbjct: 144 LLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTH----RWY 199 Query: 539 YAPE-CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP--- 594 APE + + F+ D+WS G +M E F+ + +RG + E +G P Sbjct: 200 RAPELVMQFKGFTKLVDMWSAGCVMAEMFNR-KALFRGSTFYNQLNKI--VEVVGTPKIE 256 Query: 595 ------------------AGCPREMY------------DLMNLCWTYDVENRPGFAAVEL 624 + P + DL+ ++ + R E Sbjct: 257 DVVMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRIS---TEQ 313 Query: 625 RLRNYYYDVV 634 LR+ Y++ + Sbjct: 314 ALRHPYFESL 323 >4C59-A nrPDB Length = 340 Score = 177 bits (450), Expect = 1e-44, Method: Composition-based stats. Identities = 53/283 (18%), Positives = 113/283 (39%), Gaps = 40/283 (14%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLD-NPYIV 433 + L G F V + Q + A+K L +N+ ++ E M++L +P IV Sbjct: 33 RVLAEGGFAFVYEA--QDVGSGREYALKRL--LSNEEEKNRAIIQEVCFMKKLSGHPNIV 88 Query: 434 RM-----IGICEAES----WMLVMEMAELGPLNKYLQQ---NRHVKDKNIIELVHQVSMG 481 + IG E+++ ++L+ E+ + G L ++L++ + ++++ +Q Sbjct: 89 QFCSAASIGKEESDTGQAEFLLLTELCK-GQLVEFLKKMESRGPLSCDTVLKIFYQTCRA 147 Query: 482 MKYLEESN--FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENY---------YKAQT 530 ++++ +HRDL N+LL Q K+ DFG + + +Y + + Sbjct: 148 VQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEI 207 Query: 531 HGKWPVKWYAPECI---NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 + PE I + + K D+W+ G +++ + Q P+ + Sbjct: 208 TRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILY-LLCFRQHPFEDGAKLRIV----- 261 Query: 588 GERMGCPAGCPR--EMYDLMNLCWTYDVENRPGFAAVELRLRN 628 + P + + L+ + E R A V +L+ Sbjct: 262 NGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQE 304 >5Y86-A nrPDB Length = 588 Score = 177 bits (449), Expect = 1e-44, Method: Composition-based stats. Identities = 51/231 (22%), Positives = 98/231 (42%), Gaps = 24/231 (10%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNP---- 430 K +G G+FG V + Y K+ + VA+K+++NE E E +++ L Sbjct: 213 KIIGKGSFGQVARVYDH--KLRQYVALKMVRNEKRFHRQAAE---EIRILEHLKKQDKTG 267 Query: 431 --YIVRMIGICE-AESWMLVMEMAELGPLNKYLQQNRH--VKDKNIIELVHQVSMGMKYL 485 ++ M+ + E+ + L + +++N+ + + + + + L Sbjct: 268 SMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 326 Query: 486 EESNFVHRDLAARNVLLVTQHY--AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPEC 543 ++ +H DL N+LL K+ DFG S + Y Q+ + APE Sbjct: 327 HKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQKLYTYIQSRF-----YRAPEI 380 Query: 544 INYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP 594 I ++S+ D+WSFG ++ E + GQ + G + A + + M P Sbjct: 381 ILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPP 430 >2BUJ-A nrPDB Length = 317 Score = 177 bits (449), Expect = 1e-44, Method: Composition-based stats. Identities = 54/281 (19%), Positives = 112/281 (39%), Gaps = 31/281 (11%) Query: 372 LEDKELGSGNFGTV--KKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDN 429 L ++LG G F V +G + A+K + ++ ++E EA++ + ++ Sbjct: 32 LFIQKLGEGGFSYVDLVEGLHD----GHFYALKRI--LCHEQQDREEAQREADMHRLFNH 85 Query: 430 PYIVRMIGIC------EAESWMLVMEMAELGPLNKYL----QQNRHVKDKNIIELVHQVS 479 P I+R++ C + E+W+L + + G L + + + + I+ L+ + Sbjct: 86 PNILRLVAYCLRERGAKHEAWLL-LPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGIC 144 Query: 480 MGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGL----SKALRADENYYKAQT--HGK 533 G++ + + HRDL N+LL + + D G + Q + Sbjct: 145 RGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQR 204 Query: 534 WPVKWYAPECINYYKF---SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGER 590 + + APE + ++DVWS G +++ +G+ PY + + L + Sbjct: 205 CTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMM-FGEGPYDMVFQKGDSVALAVQNQ 263 Query: 591 MGCP--AGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNY 629 + P ++ L+N T D RP + +L Sbjct: 264 LSIPQSPRHSSALWQLLNSMMTVDPHQRPHIPLLLSQLEAL 304 >4L00-A nrPDB Length = 304 Score = 177 bits (449), Expect = 1e-44, Method: Composition-based stats. Identities = 66/273 (24%), Positives = 124/273 (45%), Gaps = 27/273 (9%) Query: 372 LEDKELGSGNFGTVKKG----YYQMKKVVKTVAVKILKNEANDPALKD---ELLAEANVM 424 ++ + LG G + G Y + + +K++ + DP+ +D A++M Sbjct: 28 VQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVI-LKVLDPSHRDISLAFFEAASMM 86 Query: 425 QQLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGM 482 +Q+ + +IV + G+C + ++V E E GPL+ ++ + + ++ Q++ + Sbjct: 87 RQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASAL 146 Query: 483 KYLEESNFVHRDLAARNVLLVTQH-------YAKISDFGLSKALRADENYYKAQTHGKWP 535 YLE+ + VH ++ +N+LL + + K+SD G+ + + + + Sbjct: 147 SYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIER------- 199 Query: 536 VKWYAPECINYYK-FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP 594 + W APEC+ K S +D WSFG +WE G+ P + E E R P Sbjct: 200 IPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTP 259 Query: 595 AGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 + +E+ DLM C YD RP F A+ + Sbjct: 260 SC--KELADLMTRCMNYDPNQRPFFRAIMRDIN 290 >4JLC-A nrPDB Length = 657 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 60/248 (24%), Positives = 108/248 (43%), Gaps = 22/248 (8%) Query: 370 LTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDN 429 L L LG G V +G + KK AVK+ N + + + + E V+++L++ Sbjct: 9 LWLLSDILGQGATANVFRGRH--KKTGDLYAVKVFNNISFLRPVDVQ-MREFEVLKKLNH 65 Query: 430 PYIVRMIGICE---AESWMLVMEMAELGPLNKYLQQNRH---VKDKNIIELVHQVSMGMK 483 IV++ I E +L+ME G L L++ + + + + ++ V GM Sbjct: 66 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 125 Query: 484 YLEESNFVHRDLAARNVL--LVTQHY--AKISDFGLSKALRADENYYKA-QTHGKWPVKW 538 +L E+ VHRD+ N++ + K++DFG ++ L DE + T Sbjct: 126 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 185 Query: 539 YAPECI---NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMK----GSEVTAMLEKGERM 591 Y + + K+ + D+WS GV + A + G P+R + EV + G+ Sbjct: 186 YERAVLRKDHQKKYGATVDLWSVGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGKPS 244 Query: 592 GCPAGCPR 599 G +G + Sbjct: 245 GAISGVQK 252 >3UIM-A nrPDB Length = 326 Score = 176 bits (446), Expect = 3e-44, Method: Composition-based stats. Identities = 69/309 (22%), Positives = 118/309 (38%), Gaps = 34/309 (11%) Query: 345 TEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKIL 404 E E + +E+ + + ++ LG G FG V KG VAVK L Sbjct: 7 EEDPEVHLGQLKRFSLRELQVASDNFSNKN-ILGRGGFGKVYKGRLAD---GTLVAVKRL 62 Query: 405 KNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAES-WMLVMEMAELGP----LNKY 459 K E E ++ + ++R+ G C + +LV G L + Sbjct: 63 KEERTQGGELQ-FQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRER 121 Query: 460 LQQNRHVKDKNIIELVHQVSMGMKYLEES---NFVHRDLAARNVLLVTQHYAKISDFGLS 516 + + + + G+ YL + +HRD+ A N+LL + A + DFGL+ Sbjct: 122 PESQPPLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLA 181 Query: 517 KALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPY--- 573 K + D T + + APE ++ K S K+DV+ +GV++ E + GQ+ + Sbjct: 182 KLM--DYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELIT-GQRAFDLA 238 Query: 574 RGMKGSEVTAM-----LEKGERMG-------CPAGCPREMYDLMN---LCWTYDVENRPG 618 R +V + L K +++ E+ L+ LC RP Sbjct: 239 RLANDDDVMLLDWVKGLLKEKKLEALVDVDLQGNYKDEEVEQLIQVALLCTQSSPMERPK 298 Query: 619 FAAVELRLR 627 + V L Sbjct: 299 MSEVVRMLE 307 >2WO6-A nrPDB Length = 382 Score = 176 bits (446), Expect = 3e-44, Method: Composition-based stats. Identities = 62/248 (25%), Positives = 102/248 (41%), Gaps = 25/248 (10%) Query: 358 IRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDEL 417 ++ E ++DR + D +G G+FG V K Y ++++ + VA+KI+KN+ Sbjct: 46 VKNGEKWMDRYEI---DSLIGKGSFGQVVKAYDRVEQ--EWVAIKIIKNKKAFLNQAQIE 100 Query: 418 LAEANVMQQLDNP---YIVRMI-GICEAESWMLVMEMAELGPLNKYLQQN--RHVKDKNI 471 + +M + D YIV + LV EM L L+ R V Sbjct: 101 VRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSY-NLYDLLRNTNFRGVSLNLT 159 Query: 472 IELVHQVSMGMKYLE--ESNFVHRDLAARNVLLVT--QHYAKISDFGLSKALRADENYYK 527 + Q+ + +L E + +H DL N+LL + KI DFG S L Y Sbjct: 160 RKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYI 219 Query: 528 AQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 + +PE + + D+WS G ++ E + G+ + G EV M + Sbjct: 220 QSRF------YRSPEVLLGMPYDLAIDMWSLGCILVEMHT-GEPLFSGAN--EVDQMNKI 270 Query: 588 GERMGCPA 595 E +G P Sbjct: 271 VEVLGIPP 278 >5VDK-A nrPDB Length = 297 Score = 176 bits (446), Expect = 3e-44, Method: Composition-based stats. Identities = 56/281 (19%), Positives = 107/281 (38%), Gaps = 43/281 (15%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL-DNP 430 LE +++G G FGTV K ++ V A+K + + ++ L E L +P Sbjct: 18 LEVEKIGVGEFGTVYKCIKRLDGCV--YAIKRSMKTFTELSNENSALHEVYAHAVLGHHP 75 Query: 431 YIVRMIGICEAESWMLVM-EMAELGPLNKYLQQN----RHVKDKNIIELVHQVSMGMKYL 485 ++VR + M++ E G L + +N H ++ + +++ Q+S+G+ Y+ Sbjct: 76 HVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYI 135 Query: 486 EESNFVHRDLAARNVLLVTQHY-----------------------AKISDFGLSKALRAD 522 S+ VH D+ N+ + + KI D G + ++ Sbjct: 136 HNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSINKP 195 Query: 523 ENYYKAQTHGKWPVKWYAPECINY-YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 + + ++ A E + Y+ K+D+++ G+ + A P G Sbjct: 196 K-------VEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHH- 247 Query: 582 TAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 + KG P L+ D E RP AA+ Sbjct: 248 ---IRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAAL 285 >4EUU-A nrPDB Length = 319 Score = 175 bits (445), Expect = 4e-44, Method: Composition-based stats. Identities = 58/248 (23%), Positives = 108/248 (43%), Gaps = 22/248 (8%) Query: 370 LTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDN 429 L L LG G V +G + KK A+K+ N + + + + E V+++L++ Sbjct: 10 LWLLSDILGQGATANVFRGRH--KKTGDLFAIKVFNNISFLRPVDVQ-MREFEVLKKLNH 66 Query: 430 PYIVRMIGICE---AESWMLVMEMAELGPLNKYLQQNRH---VKDKNIIELVHQVSMGMK 483 IV++ I E +L+ME G L L++ + + + + ++ V GM Sbjct: 67 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 126 Query: 484 YLEESNFVHRDLAARNVL--LVTQHY--AKISDFGLSKALRADENYYKA-QTHGKWPVKW 538 +L E+ VHR++ N++ + K++DFG ++ L DE + T Sbjct: 127 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 186 Query: 539 YAPECI---NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMK----GSEVTAMLEKGERM 591 Y + + K+ + D+WS GV + A + G P+R + EV + G+ Sbjct: 187 YERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGKPS 245 Query: 592 GCPAGCPR 599 G +G + Sbjct: 246 GAISGVQK 253 >3M42-A nrPDB Length = 299 Score = 175 bits (443), Expect = 6e-44, Method: Composition-based stats. Identities = 52/272 (19%), Positives = 100/272 (36%), Gaps = 53/272 (19%) Query: 368 KLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM-QQ 426 + + LG G G V + + K+ + A+K+L++ + E + + Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFN--KRTQEKFALKMLQDCP-------KARREVELHWRA 67 Query: 427 LDNPYIVRMIGICEA-----ESWMLVMEMAELGPLNKYLQQNRH--VKDKNIIELVHQVS 479 P+IVR++ + E + ++VME + G L +Q ++ E++ + Sbjct: 68 SQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIG 127 Query: 480 MGMKYLEESNFVHRDLAARNVLLVT---QHYAKISDFGLSKALRADENYYKAQTHGKWPV 536 ++YL N HRD+ N+L + K++DFG +K Sbjct: 128 EAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT---------------- 171 Query: 537 KWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMG---C 593 K+ D+WS GV+M+ G P+ G ++ ++ RMG Sbjct: 172 ---------GEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEF 221 Query: 594 P----AGCPREMYDLMNLCWTYDVENRPGFAA 621 P + E+ L+ + R Sbjct: 222 PNPEWSEVSEEVKMLIRNLLKTEPTQRMTITE 253 >4EUT-A nrPDB Length = 396 Score = 174 bits (442), Expect = 9e-44, Method: Composition-based stats. Identities = 58/248 (23%), Positives = 108/248 (43%), Gaps = 22/248 (8%) Query: 370 LTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDN 429 L L LG G V +G + KK A+K+ N + + + + E V+++L++ Sbjct: 10 LWLLSDILGQGATANVFRGRH--KKTGDLFAIKVFNNISFLRPVDVQ-MREFEVLKKLNH 66 Query: 430 PYIVRMIGICE---AESWMLVMEMAELGPLNKYLQQNRH---VKDKNIIELVHQVSMGMK 483 IV++ I E +L+ME G L L++ + + + + ++ V GM Sbjct: 67 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 126 Query: 484 YLEESNFVHRDLAARNVL--LVTQHY--AKISDFGLSKALRADENYYKA-QTHGKWPVKW 538 +L E+ VHR++ N++ + K++DFG ++ L DE + T Sbjct: 127 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 186 Query: 539 YAPECI---NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMK----GSEVTAMLEKGERM 591 Y + + K+ + D+WS GV + A + G P+R + EV + G+ Sbjct: 187 YERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGKPS 245 Query: 592 GCPAGCPR 599 G +G + Sbjct: 246 GAISGVQK 253 >6O8B-A nrPDB Length = 665 Score = 174 bits (440), Expect = 1e-43, Method: Composition-based stats. Identities = 58/248 (23%), Positives = 109/248 (43%), Gaps = 22/248 (8%) Query: 370 LTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDN 429 L L LG G V +G + KK A+K+ N + + + + E V+++L++ Sbjct: 16 LWLLSDILGQGATANVFRGRH--KKTGDLFAIKVFNNISFLRPVDVQ-MREFEVLKKLNH 72 Query: 430 PYIVRMIGICE---AESWMLVMEMAELGPLNKYLQQNRH---VKDKNIIELVHQVSMGMK 483 IV++ I E +L+ME G L L++ + + + + ++ V GM Sbjct: 73 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 132 Query: 484 YLEESNFVHRDLAARNVL--LVTQHY--AKISDFGLSKALRADENYYKA-QTHGKWPVKW 538 +L E+ VHR++ N++ + K++DFG ++ L DE + + T Sbjct: 133 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDM 192 Query: 539 YAPECI---NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMK----GSEVTAMLEKGERM 591 Y + + K+ + D+WS GV + A + G P+R + EV + G+ Sbjct: 193 YERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGKPS 251 Query: 592 GCPAGCPR 599 G +G + Sbjct: 252 GAISGVQK 259 >5ZTN-A nrPDB Length = 429 Score = 174 bits (440), Expect = 1e-43, Method: Composition-based stats. Identities = 51/221 (23%), Positives = 94/221 (42%), Gaps = 19/221 (8%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K +G G+FG V K Y KV + VA+K+++NE E + +++ D + Sbjct: 103 KVIGKGSFGQVVKAYDH--KVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMN 160 Query: 435 MIGICEAESW----MLVMEMAELGPLNKYLQQNRH--VKDKNIIELVHQVSMGMKYLEES 488 +I + E ++ + E+ + L + +++N+ + + H + + L ++ Sbjct: 161 VIHMLENFTFRNHICMTFELLSM-NLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKN 219 Query: 489 NFVHRDLAARNVLLVTQHY--AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY 546 +H DL N+LL Q K+ DFG S Y + APE I Sbjct: 220 RIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRF------YRAPEVILG 273 Query: 547 YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMK-GSEVTAMLE 586 ++ D+WS G ++ E + G G G ++ M+E Sbjct: 274 ARYGMPIDMWSLGCILAELLT-GYPLLPGEDEGDQLACMIE 313 >6NT9-A nrPDB Length = 742 Score = 174 bits (440), Expect = 1e-43, Method: Composition-based stats. Identities = 58/248 (23%), Positives = 108/248 (43%), Gaps = 22/248 (8%) Query: 370 LTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDN 429 L L LG G V +G + KK A+K+ N + + + + E V+++L++ Sbjct: 8 LWLLSDILGQGATANVFRGRH--KKTGDLFAIKVFNNISFLRPVDVQ-MREFEVLKKLNH 64 Query: 430 PYIVRMIGICE---AESWMLVMEMAELGPLNKYLQQNRH---VKDKNIIELVHQVSMGMK 483 IV++ I E +L+ME G L L++ + + + + ++ V GM Sbjct: 65 KNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 Query: 484 YLEESNFVHRDLAARNVL--LVTQHY--AKISDFGLSKALRADENYYKA-QTHGKWPVKW 538 +L E+ VHR++ N++ + K++DFG ++ L DE + T Sbjct: 125 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 Query: 539 YAPECI---NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMK----GSEVTAMLEKGERM 591 Y + + K+ + D+WS GV + A + G P+R + EV + G+ Sbjct: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGKPS 243 Query: 592 GCPAGCPR 599 G +G + Sbjct: 244 GAISGVQK 251 >3MY0-A nrPDB Length = 305 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 53/292 (18%), Positives = 107/292 (36%), Gaps = 50/292 (17%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 +G G +G V +G + ++VAVKI + ++ E L + I+ I Sbjct: 16 VGKGRYGEVWRGLWH----GESVAVKIFSSRDEQSWFRET---EIYNTVLLRHDNILGFI 68 Query: 437 GICEAE-----SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE----- 486 L+ E G L +LQ + ++ + L + G+ +L Sbjct: 69 ASDMTSRNSSTQLWLITHYHEHGSLYDFLQ-RQTLEPHLALRLAVSAACGLAHLHVEIFG 127 Query: 487 ---ESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPV-KWYAPE 542 + HRD +RNVL+ + I+D GL+ +Y + + ++ APE Sbjct: 128 TQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPE 187 Query: 543 CINYY-------KFSSKSDVWSFGVLMWEA----FSYG-----QKPYRGMKGS----EVT 582 ++ + +D+W+FG+++WE G + P+ + + E Sbjct: 188 VLDEQIRTDCFESY-KWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDM 246 Query: 583 AMLEKGER--MGCPAGCPRE-----MYDLMNLCWTYDVENRPGFAAVELRLR 627 + ++ P + + +M CW + R ++ L+ Sbjct: 247 KKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQ 298 >4Y83-A nrPDB Length = 332 Score = 172 bits (437), Expect = 3e-43, Method: Composition-based stats. Identities = 57/285 (20%), Positives = 107/285 (37%), Gaps = 30/285 (10%) Query: 357 EIRPKEVYLDRKLL----TLEDKELG-----SGNFGTVKKGYYQMKKVVKTVAVKILKNE 407 + +D +L L + +G G FG V Q K K +A K++ + Sbjct: 52 TPQNGRYQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLA--QDIKTKKRMACKLIPVD 109 Query: 408 ANDPALKDELLAEANVMQQLDNPYIVRMIGICE-AESWMLVMEMAELGPLNKYLQQNRHV 466 P+ + + I + G E+ L ME E G + + L+ + Sbjct: 110 QFKPSD-------VEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPM 162 Query: 467 KDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYY 526 ++ II + V G+ +L +H D+ N++ ++ + DFGLS + D + Sbjct: 163 REFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFP 221 Query: 527 KAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPY-RGMKGSEVTAML 585 K + + +PE I S+K+D++S G + + G P+ + S + L Sbjct: 222 K---DLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQT-GTPPWVKRYPRSAYPSYL 277 Query: 586 EKGERMGCP-----AGCPREMYDLMNLCWTYDVENRPGFAAVELR 625 + P C M +L+ + +RP A + Sbjct: 278 YIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKH 322 >5E8V-A nrPDB Length = 316 Score = 172 bits (435), Expect = 6e-43, Method: Composition-based stats. Identities = 67/314 (21%), Positives = 121/314 (38%), Gaps = 56/314 (17%) Query: 364 YLDRKLLTLE-DKELGSGNFGTVKKGYYQM--KKVVKTVAVKILKNEANDPALKDELLAE 420 + +LL +E D +G G F V K + + +TVAVKI E E Sbjct: 3 MHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYAS-----WKTE 57 Query: 421 ANVMQ--QLDNPYIVRMIGICEAES-----WMLVMEMAELGPLNKYLQQNRHVKDKNIIE 473 ++ L + I++ + E ++ + L+ G L +YL ++ + +++ + Sbjct: 58 KDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRH-VISWEDLRK 116 Query: 474 LVHQVSMGMKYLEESN---------FVHRDLAARNVLLVTQHYAKISDFGLSKALRADEN 524 L ++ G+ +L + VHRDL + N+L+ + DFGLS L + Sbjct: 117 LGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLS 176 Query: 525 Y-YKAQTHGKWPVKWYAPECI-------NYYKFSSKSDVWSFGVLMWEAFSYG------- 569 A + ++ APE + N F ++DV+S +++WE S Sbjct: 177 VDDLANSGQVGTARYMAPEVLASAMNLENVESF-KQTDVYSMALVLWEMTSRCNAVGEVK 235 Query: 570 --QKPYRGMKGSEV-------TAMLEKGERMGCPAGCP-----REMYDLMNLCWTYDVEN 615 + P+ G K E +L R P+ + + + + CW +D E Sbjct: 236 DYEPPF-GSKVREHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEA 294 Query: 616 RPGFAAVELRLRNY 629 R V R Sbjct: 295 RLTAQCVAERFSEL 308 >4TN6-A nrPDB Length = 318 Score = 171 bits (433), Expect = 1e-42, Method: Composition-based stats. Identities = 63/277 (22%), Positives = 122/277 (44%), Gaps = 29/277 (10%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 +++GSG+FG + G + VA+K+ + P L E+ + + + + Sbjct: 12 GRKIGSGSFGDIYLGTDIA--AGEEVAIKLECVKTKHPQLHI----ESKIYKMMQGGVGI 65 Query: 434 RMIGIC--EAESWMLVMEMA--ELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 I C E + ++VME+ L L + +R K ++ L Q+ ++Y+ N Sbjct: 66 PTIRWCGAEGDYNVMVMELLGPSLEDLFNF--CSRKFSLKTVLLLADQMISRIEYIHSKN 123 Query: 490 FVHRDLAARNVLL---VTQHYAKISDFGLSKALRADENY----YKAQTHGKWPVKWYAPE 542 F+HRD+ N L+ + I DFGL+K R + Y+ + ++ + Sbjct: 124 FIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASIN 183 Query: 543 CINYYKFSSKSDVWSFG-VLMWEAFSYGQKPYRGMKGSEVTAMLEKG--ERMGCP----- 594 + S + D+ S G VLM+ F+ G P++G+K + E+ ++M P Sbjct: 184 THLGIEQSRRDDLESLGYVLMY--FNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLC 241 Query: 595 AGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYY 631 G P E +N C + +++P ++ + RN ++ Sbjct: 242 KGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFH 278 >3E3P-A nrPDB Length = 360 Score = 171 bits (433), Expect = 1e-42, Method: Composition-based stats. Identities = 70/320 (21%), Positives = 112/320 (35%), Gaps = 74/320 (23%) Query: 362 EVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEA 421 +DR + ++ G G FGTV+ G + K +VA+K + DP ++ L Sbjct: 19 RKEMDRFQV---ERMAGQGTFGTVQLG--KEKSTGMSVAIKKV---IQDPRFRNRELQIM 70 Query: 422 NVMQQLDNPYIVRMIGIC------EAESWML--VMEMAELGPLN----KYLQQNRHVKDK 469 + L +P IV++ + L VME L+ Y ++ Sbjct: 71 QDLAVLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVP-DTLHRCCRNYYRRQVAPPPI 129 Query: 470 NIIELVHQVSMGMKYLE--ESNFVHRDLAARNVLLVT-QHYAKISDFGLSKALRADENYY 526 I + Q+ + L N HRD+ NVL+ K+ DFG +K L E Sbjct: 130 LIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEP-- 187 Query: 527 KAQTHGKWPVKWYAPECINY-YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAML 585 + APE I +++ D+WS G + E G+ +RG + + Sbjct: 188 --NVAYICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMM-LGEPIFRGDNSA--GQLH 242 Query: 586 EKGERMGCPA--------------------GCP-------------REMYDLMNLCWTYD 612 E +GCP+ G P +E YDL++ Y Sbjct: 243 EIVRVLGCPSREVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYL 302 Query: 613 VENR---------PGFAAVE 623 E R P F + Sbjct: 303 PEERMKPYEALCHPYFDELH 322 >5X8I-B nrPDB Length = 346 Score = 170 bits (432), Expect = 1e-42, Method: Composition-based stats. Identities = 63/330 (19%), Positives = 116/330 (35%), Gaps = 86/330 (26%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLD--NPY-- 431 LG G FG V + K + VAVKI+KN + +E V++ L+ +P Sbjct: 20 TLGEGAFGKVVECIDH-KAGGRHVAVKIVKNVDR---YCEAARSEIQVLEHLNTTDPNST 75 Query: 432 --IVRMIGICEAESW-MLVMEMAELGPLNKYLQQNRHVK--DKNIIELVHQVSMGMKYLE 486 V+M+ E +V E+ L ++++N + +I ++ +Q+ + +L Sbjct: 76 FRCVQMLEWFEHHGHICIVFELLGLST-YDFIKENGFLPFRLDHIRKMAYQICKSVNFLH 134 Query: 487 ESNFVHRDLAARNVLLVT-------------------QHYAKISDFGLSKALRADENYYK 527 + H DL N+L V K+ DFG + D+ ++ Sbjct: 135 SNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATY---DDEHHS 191 Query: 528 AQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 + + APE I +S DVWS G ++ E + G + E AM+E+ Sbjct: 192 TLVSTR---HYRAPEVILALGWSQPCDVWSIGCILIEYY-LGFTVFPTHDSKEHLAMMER 247 Query: 588 G--------------------ERMGCPAGCP-----------------------REMYDL 604 +R+ ++DL Sbjct: 248 ILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDL 307 Query: 605 MNLCWTYDVENRPGFAAVELRLRNYYYDVV 634 + YD R + L++ ++D++ Sbjct: 308 IQKMLEYDPAKRIT---LREALKHPFFDLL 334 >6BFN-A nrPDB Length = 342 Score = 170 bits (430), Expect = 2e-42, Method: Composition-based stats. Identities = 59/311 (18%), Positives = 105/311 (33%), Gaps = 61/311 (19%) Query: 373 EDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPA--LKDELLAEANVMQQLDNP 430 E+ ++G G FG V + + AVK LK A+ +K L E + + +P Sbjct: 26 EELKIGEGGFGCVYRAVMRNT----VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHP 81 Query: 431 YIVRMIGICEAESWM-LVMEMAELGPLNKYLQQN----RHVKDKNIIELVHQVSMGMKYL 485 IV G C + LV G L L + ++++ + +++L Sbjct: 82 NIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFL 141 Query: 486 E--ESNFVHRDLAARNVLLVTQHYAKISDFGLSK------ALRADENYYKAQTHGKWPVK 537 + +H D+ + NVLL + K+ DFGL++ + + + + + Sbjct: 142 HQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLA 201 Query: 538 WYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVT--------------- 582 + E I + + +D +SFGV++ E + GQ+ + Sbjct: 202 YLPEEYIKTGRLAVDTDTFSFGVVVLETLA-GQRAVKTHGARTKYLKDLVEEEAEEAGVA 260 Query: 583 ----------------------AMLEKGERMGCPAGCPRE----MYDLMNLCWTYDVENR 616 + K P CP E + L C + R Sbjct: 261 LRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRR 320 Query: 617 PGFAAVELRLR 627 P V RL Sbjct: 321 PPMTQVYERLE 331 >3G2F-A nrPDB Length = 336 Score = 170 bits (430), Expect = 2e-42, Method: Composition-based stats. Identities = 74/323 (22%), Positives = 113/323 (34%), Gaps = 64/323 (19%) Query: 357 EIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE 416 E E LD L L + +G G +G V KG + VAVK+ A + Sbjct: 2 EAAASEPSLDLDNLKLL-ELIGRGRYGAVYKGSLDERP----VAVKVF-----SFANRQN 51 Query: 417 LLAEANVMQ--QLDNPYIVRMI---GICEAES---WMLVMEMAELGPLNKYLQQNRHVKD 468 + E N+ + +++ I R I A+ ++LVME G L KYL + Sbjct: 52 FINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTS-DW 110 Query: 469 KNIIELVHQVSMGMKYLE---------ESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL 519 + L H V+ G+ YL + HRDL +RNVL+ ISDFGLS L Sbjct: 111 VSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRL 170 Query: 520 RA-----DENYYKAQTHGKWPVKWYAPECINY-------YKFSSKSDVWSFGVLMWEAFS 567 A +++ APE + + D+++ G++ WE F Sbjct: 171 TGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFM 230 Query: 568 YGQKPYRGMKGSEVTAML------------------EKGERMGCPAGCPR------EMYD 603 + G E + +R P + + Sbjct: 231 RCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKE 290 Query: 604 LMNLCWTYDVENRPGFAAVELRL 626 + CW D E R E R+ Sbjct: 291 TIEDCWDQDAEARLTAQCAEERM 313 >5FQD-C nrPDB Length = 341 Score = 167 bits (424), Expect = 1e-41, Method: Composition-based stats. Identities = 68/277 (24%), Positives = 120/277 (43%), Gaps = 33/277 (11%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDN----P 430 +++GSG+FG + + VAVK+ +A P +LL E+ + + L P Sbjct: 25 RKIGSGSFGDIYLAINITN--GEEVAVKLESQKARHP----QLLYESKLYKILQGGVGIP 78 Query: 431 YIVRMIGICEAESWMLVMEMA--ELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 +I R G E + +LVM++ L L + +R K ++ L Q+ ++Y+ Sbjct: 79 HI-RWYG-QEKDYNVLVMDLLGPSLEDLFNF--CSRRFTMKTVLMLADQMISRIEYVHTK 134 Query: 489 NFVHRDLAARNVLLVTQHYA-K--ISDFGLSKALRADENY----YKAQTHGKWPVKWYAP 541 NF+HRD+ N L+ + K + DFGL+K R + Y+ + ++ + Sbjct: 135 NFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASI 194 Query: 542 ECINYYKFSSKSDVWSFG-VLMWEAFSYGQKPYRGMKGSEVTAMLEKG--ERMGCP---- 594 + S + D+ S G VLM+ F+ P++G+K + EK ++M P Sbjct: 195 NAHLGIEQSRRDDMESLGYVLMY--FNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVL 252 Query: 595 -AGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYY 630 G P E +N C E P + + R + Sbjct: 253 CKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILF 289 >2H34-A nrPDB Length = 309 Score = 167 bits (423), Expect = 1e-41, Method: Composition-based stats. Identities = 48/246 (19%), Positives = 108/246 (43%), Gaps = 9/246 (3%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNE-ANDPALKDELLAEANVMQQLDNPYIV 433 + +G G G V + +++ + VA+K++ ++DP + + EA +L P++V Sbjct: 40 RLVGRGGMGDVYEAEDTVRE--RIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPHVV 97 Query: 434 RMIGICEAESWMLV-MEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 + E + + V M + L L++ + + +V Q+ + + H Sbjct: 98 PIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHAAGATH 157 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSK 552 RD+ N+L+ +A + DFG++ A ++ T G + + APE + + + Sbjct: 158 RDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVG--TLYYMAPERFSESHATYR 215 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG--ERMGCPAGCPREMYDLMNLCWT 610 +D+++ +++E + G PY+G + S + A + + G P ++ Sbjct: 216 ADIYALTCVLYECLT-GSPPYQGDQLSVMGAHINQAIPRPSTVRPGIPVAFDAVIARGMA 274 Query: 611 YDVENR 616 + E+R Sbjct: 275 KNPEDR 280 >4PL5-B nrPDB Length = 435 Score = 166 bits (421), Expect = 2e-41, Method: Composition-based stats. Identities = 75/306 (24%), Positives = 127/306 (41%), Gaps = 33/306 (10%) Query: 342 PMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGT-VKKGYYQMKKVVKTVA 400 MD E + S D E+ + V + + +D LG G GT V KG + + VA Sbjct: 2 AMDPE-FPSLEQDDEDEETRMVIVGKISFCPKD-VLGHGAEGTIVYKGMFDNRD----VA 55 Query: 401 VKILKNEANDPALKDELLAEANVMQQLD-NPYIVRMIGICEAESW-MLVMEMAELGPLNK 458 VK + E A E ++++ D +P ++R + + + +E+ L + Sbjct: 56 VKRILPECFSFAD-----REVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-TLQE 109 Query: 459 YLQQNR--HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLL---VTQHYAK--IS 511 Y++Q H+ + I L+HQ + G+ +L N VHRDL N+LL K IS Sbjct: 110 YVEQKDFAHLGLEPI-TLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMIS 168 Query: 512 DFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSK---SDVWSFGVLMWEAFSY 568 DFGL K L + + ++ W APE ++ + D++S G + + S Sbjct: 169 DFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISE 228 Query: 569 GQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE---MYDLMNLCWTYDVENRPGFAAVELR 625 G P+ G +L + C E +L+ D + RP V Sbjct: 229 GYHPF-GKSLQRQANILLGACNLDCFHSDKHEDVIARELIEKMIAMDPQQRPSAKHV--- 284 Query: 626 LRNYYY 631 L++ ++ Sbjct: 285 LKHPFF 290 >2B3O-A nrPDB Length = 532 Score = 166 bits (421), Expect = 2e-41, Method: Composition-based stats. Identities = 58/264 (21%), Positives = 97/264 (36%), Gaps = 75/264 (28%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74 +F +++ +AE L G G +L R SR G F+LSV G + H I+ + Y Sbjct: 4 WFHRDLSGLDAETLLKGRG-VHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGD-FY 61 Query: 75 AIAGGRTHASPADLCHYHSQ------ESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLI 128 + GG A+ +L Y++Q + DG + LK P N Sbjct: 62 DLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLN-------------------- 101 Query: 129 REYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKT 188 P E+ W+HG +S ++E ++ + Sbjct: 102 --------------------CSDPTSER-----------WYHGHMSGGQAETLLQAKGEP 130 Query: 189 NGKFLIRAR-DNNGSYALCLLHEG---------KVLHYRIDKDKTGKLSIPEGKKFDTLW 238 FL+R G + L +L + +V H ++ + G+ ++ + FD+L Sbjct: 131 W-TFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEG-GRYTVGGLETFDSLT 188 Query: 239 QLVEHYSYK----ADGLLRVLTVP 258 LVEH+ A G L P Sbjct: 189 DLVEHFKKTGIEEASGAFVYLRQP 212 Score = 94.7 bits (234), Expect = 1e-19, Method: Composition-based stats. Identities = 42/162 (25%), Positives = 70/162 (43%), Gaps = 18/162 (11%) Query: 168 WFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHYRIDKDKTGKL 226 WFH +S ++E + L G +G FL R +R N G ++L + +V H RI ++ Sbjct: 4 WFHRDLSGLDAETL-LKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRI-QNSGDFY 61 Query: 227 SIPEGKKFDTLWQLVEHYSYKA------DGLLRVLTVP--CQKIGTQ----GNVNFGGRP 274 + G+KF TL +LVE+Y+ + DG + L P C ++ G+++ G Sbjct: 62 DLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAE 121 Query: 275 QLPGSHPATWSAGGIISRIKSYSF---PKPGHRKSSPAQGNR 313 L + W+ S + F K+ P R Sbjct: 122 TLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLR 163 Score = 85.4 bits (210), Expect = 7e-17, Method: Composition-based stats. Identities = 35/168 (20%), Positives = 64/168 (38%), Gaps = 27/168 (16%) Query: 13 LPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGR---------KAHH 63 ++ G+++ +AE L G +L+R+S + G F LSV + + H Sbjct: 108 ERWYHGHMSGGQAETLLQAKGEP-WTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTH 166 Query: 64 YTIERELNGTYAIAGGRTHASPADLCHYHSQ----ESDGLVCLLKKPF-----------N 108 + E G Y + G T S DL + + E+ G L++P+ N Sbjct: 167 IKVMCEG-GRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIEN 225 Query: 109 RPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEK 156 R + K + K E + + + L Q + Q+P+ + Sbjct: 226 RVLELNKKQESEDTAKAG-FWEEFESLQKQEVKNLHQRLEGQRPENKG 272 >3PS5-A nrPDB Length = 595 Score = 165 bits (417), Expect = 7e-41, Method: Composition-based stats. Identities = 58/264 (21%), Positives = 97/264 (36%), Gaps = 75/264 (28%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74 +F +++ +AE L G G +L R SR G F+LSV G + H I+ + Y Sbjct: 4 WFHRDLSGLDAETLLKGRG-VHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGD-FY 61 Query: 75 AIAGGRTHASPADLCHYHSQ------ESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLI 128 + GG A+ +L Y++Q + DG + LK P N Sbjct: 62 DLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLN-------------------- 101 Query: 129 REYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKT 188 P E+ W+HG +S ++E ++ + Sbjct: 102 --------------------CSDPTSER-----------WYHGHMSGGQAETLLQAKGEP 130 Query: 189 NGKFLIRAR-DNNGSYALCLLHEG---------KVLHYRIDKDKTGKLSIPEGKKFDTLW 238 FL+R G + L +L + +V H ++ + G+ ++ + FD+L Sbjct: 131 W-TFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEG-GRYTVGGLETFDSLT 188 Query: 239 QLVEHYSYK----ADGLLRVLTVP 258 LVEH+ A G L P Sbjct: 189 DLVEHFKKTGIEEASGAFVYLRQP 212 Score = 93.9 bits (232), Expect = 2e-19, Method: Composition-based stats. Identities = 42/162 (25%), Positives = 70/162 (43%), Gaps = 18/162 (11%) Query: 168 WFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHYRIDKDKTGKL 226 WFH +S ++E + L G +G FL R +R N G ++L + +V H RI ++ Sbjct: 4 WFHRDLSGLDAETL-LKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRI-QNSGDFY 61 Query: 227 SIPEGKKFDTLWQLVEHYSYKA------DGLLRVLTVP--CQKIGTQ----GNVNFGGRP 274 + G+KF TL +LVE+Y+ + DG + L P C ++ G+++ G Sbjct: 62 DLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAE 121 Query: 275 QLPGSHPATWSAGGIISRIKSYSF---PKPGHRKSSPAQGNR 313 L + W+ S + F K+ P R Sbjct: 122 TLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLR 163 Score = 84.7 bits (208), Expect = 1e-16, Method: Composition-based stats. Identities = 35/168 (20%), Positives = 64/168 (38%), Gaps = 27/168 (16%) Query: 13 LPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGR---------KAHH 63 ++ G+++ +AE L G +L+R+S + G F LSV + + H Sbjct: 108 ERWYHGHMSGGQAETLLQAKGEP-WTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTH 166 Query: 64 YTIERELNGTYAIAGGRTHASPADLCHYHSQ----ESDGLVCLLKKPF-----------N 108 + E G Y + G T S DL + + E+ G L++P+ N Sbjct: 167 IKVMCEG-GRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIEN 225 Query: 109 RPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEK 156 R + K + K E + + + L Q + Q+P+ + Sbjct: 226 RVLELNKKQESEDTAKAG-FWEEFESLQKQEVKNLHQRLEGQRPENKG 272 >6FYV-A nrPDB Length = 337 Score = 164 bits (416), Expect = 9e-41, Method: Composition-based stats. Identities = 64/330 (19%), Positives = 119/330 (36%), Gaps = 86/330 (26%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDN--PY-- 431 LG G FG V + VAVKI+KN ++ +E V++ L++ P Sbjct: 21 TLGEGAFGKVVECIDHGMD-GMHVAVKIVKNVGR---YREAARSEIQVLEHLNSTDPNSV 76 Query: 432 --IVRMIGICEAESW-MLVMEMAELGPLNKYLQQNRHVKD--KNIIELVHQVSMGMKYLE 486 V+M+ + +V E+ L ++++N + +I ++ +Q+ + +L Sbjct: 77 FRCVQMLEWFDHHGHVCIVFELLGLST-YDFIKENSFLPFQIDHIRQMAYQICQSINFLH 135 Query: 487 ESNFVHRDLAARNVLLVTQHYA-------------------KISDFGLSKALRADENYYK 527 + H DL N+L V Y K+ DFG + D+ ++ Sbjct: 136 HNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATY---DDEHHS 192 Query: 528 AQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 + + APE I +S DVWS G ++ E + G ++ E AM+E+ Sbjct: 193 TLVSTR---HYRAPEVILALGWSQPCDVWSIGCILIEYY-LGFTVFQTHDSKEHLAMMER 248 Query: 588 -------------------------------------------GERMGCPAGCPREMYDL 604 E M C +++DL Sbjct: 249 ILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDL 308 Query: 605 MNLCWTYDVENRPGFAAVELRLRNYYYDVV 634 + YD R ++ L++ ++D++ Sbjct: 309 VRRMLEYDPTQRIT---LDEALQHPFFDLL 335 >3SV0-A nrPDB Length = 483 Score = 164 bits (414), Expect = 1e-40, Method: Composition-based stats. Identities = 61/278 (21%), Positives = 124/278 (44%), Gaps = 33/278 (11%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDN---- 429 +++GSG+FG + G + + VA+K+ + P +LL E+ + + L Sbjct: 12 GRKIGSGSFGEIYLGTN--IQTNEEVAIKLENVKTKHP----QLLYESKIYRILQGGTGI 65 Query: 430 PYIVRMIGICEAESWMLVMEMA--ELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 487 P VR G+ E + +LVM++ L L + +R + K ++ L Q+ ++++ Sbjct: 66 PN-VRWFGV-EGDYNVLVMDLLGPSLEDLFNF--CSRKLSLKTVLMLADQMINRVEFVHS 121 Query: 488 SNFVHRDLAARNVLLV---TQHYAKISDFGLSKALRADENY----YKAQTHGKWPVKWYA 540 +F+HRD+ N L+ + I DFGL+K R + Y+ + ++ + Sbjct: 122 KSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTARYAS 181 Query: 541 PECINYYKFSSKSDVWSFG-VLMWEAFSYGQKPYRGMKG---SEVTAMLEKGER-MGCPA 595 + S + D+ S G VLM+ F G P++G+K + + + + A Sbjct: 182 VNTHLGIEQSRRDDLESLGYVLMY--FLRGSLPWQGLKAGTKKQKYEKISEKKVATSIEA 239 Query: 596 GC---PREMYDLMNLCWTYDVENRPGFAAVELRLRNYY 630 C P E + C + +++P ++ ++ R+ + Sbjct: 240 LCRGYPTEFASYFHYCRSLRFDDKPDYSYLKRLFRDLF 277 >6HV0-A nrPDB Length = 416 Score = 164 bits (414), Expect = 1e-40, Method: Composition-based stats. Identities = 64/272 (23%), Positives = 113/272 (41%), Gaps = 31/272 (11%) Query: 376 ELGSGNFGT-VKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLD-NPYIV 433 LG G GT V +G + + VAVK + E A E ++++ D +P ++ Sbjct: 15 VLGHGAEGTIVYRGMFDNRD----VAVKRILPECFSFAD-----REVQLLRESDEHPNVI 65 Query: 434 RMIGICEAESW-MLVMEMAELGPLNKYLQQNR--HVKDKNIIELVHQVSMGMKYLEESNF 490 R + + + +E+ L +Y++Q H+ + I L+ Q + G+ +L N Sbjct: 66 RYFCTEKDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPI-TLLQQTTSGLAHLHSLNI 123 Query: 491 VHRDLAARNVLL---VTQHYAK--ISDFGLSKALRADENYYKAQTHGKWPVKWYAPECIN 545 VHRDL N+L+ K ISDFGL K L + + ++ W APE ++ Sbjct: 124 VHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLS 183 Query: 546 Y---YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGC--PAGCPRE 600 + D++S G + + S G P+ G +L + C P Sbjct: 184 EDCKENPTYTVDIFSAGCVFYYVISEGSHPF-GKSLQRQANILLGACSLDCLHPEKHEDV 242 Query: 601 M-YDLMNLCWTYDVENRPGFAAVELRLRNYYY 631 + +L+ D + RP V L++ ++ Sbjct: 243 IARELIEKMIAMDPQKRPSAKHV---LKHPFF 271 >3EB0-A nrPDB Length = 383 Score = 164 bits (414), Expect = 2e-40, Method: Composition-based stats. Identities = 57/315 (18%), Positives = 109/315 (34%), Gaps = 85/315 (26%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 K LG+G+FG V + + + K A+K + DP K+ E ++M+ LD+ I+ Sbjct: 12 GKTLGTGSFGIVCEVFD--IESGKRFALKKV---LQDPRYKN---RELDIMKVLDHVNII 63 Query: 434 RMIGICEA-------------------------------------ESWML--VMEMAE-- 452 +++ ++ L +ME Sbjct: 64 KLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPDT 123 Query: 453 -LGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVT-QHYAKI 510 L +++ R + I ++Q+ + ++ HRD+ +N+L+ + + K+ Sbjct: 124 LHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLKL 183 Query: 511 SDFGLSKALRADENYYKAQTHGKWPVKWYAPE-CINYYKFSSKSDVWSFGVLMWEAFSYG 569 DFG +K L E + APE + +++ D+WS G + E G Sbjct: 184 CDFGSAKKLIPSEP----SVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELI-LG 238 Query: 570 QKPYRGMKGSEVTAML---------EKGERMG-------------------CPAGCPREM 601 + + G + + E+ RM P G P Sbjct: 239 KPLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKILPEGTPSLA 298 Query: 602 YDLMNLCWTYDVENR 616 DL+ Y+ + R Sbjct: 299 IDLLEQILRYEPDLR 313 >5TE0-A nrPDB Length = 347 Score = 163 bits (413), Expect = 2e-40, Method: Composition-based stats. Identities = 49/269 (18%), Positives = 100/269 (37%), Gaps = 30/269 (11%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLD-NPYI 432 D+ L G F V A+K + N+ E +M+ L + I Sbjct: 24 DEVLAEGGFAIVFLVR---TSNGMKCALKRM--FVNNEHDLQVCKREIQIMRDLSGHKNI 78 Query: 433 VRMIG-----ICEAESW--MLVMEMAELGPLNKYLQQN--RHVKDKNIIELVHQVSMGMK 483 V I + + W +++M+ G + + Q + ++++ + Sbjct: 79 VGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVA 138 Query: 484 YLEESN--FVHRDLAARNVLLVTQHYAKISDFGLSKA-----LRADENYYKAQTHGKWPV 536 L + +HRDL N+LL + + + DFG + N + + + Sbjct: 139 RLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTL 198 Query: 537 KWYAPECIN---YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGC 593 + APE +N ++K+D+W+ G L+++ Y P+ G A+ + + Sbjct: 199 SYRAPEMVNLYSGKIITTKADIWALGCLLYK-LCYFTLPF----GESQVAICDGNFTIPD 253 Query: 594 PAGCPREMYDLMNLCWTYDVENRPGFAAV 622 + ++M+ L+ D + RP V Sbjct: 254 NSRYSQDMHCLIRYMLEPDPDKRPDIYQV 282 >3SOC-A nrPDB Length = 322 Score = 162 bits (411), Expect = 4e-40, Method: Composition-based stats. Identities = 61/290 (21%), Positives = 109/290 (37%), Gaps = 52/290 (17%) Query: 379 SGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGI 438 G FG V K + + VAVKI + + E + + + I++ IG Sbjct: 34 RGRFGCVWKAQL----LNEYVAVKIFPIQDKQSWQNE---YEVYSLPGMKHENILQFIGA 86 Query: 439 CEAES-----WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE------ 487 + + L+ E G L+ +L+ N V + + ++ G+ YL E Sbjct: 87 EKRGTSVDVDLWLITAFHEKGSLSDFLKAN-VVSWNELCHIAETMARGLAYLHEDIPGLK 145 Query: 488 ----SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGK-WPVKWYAPE 542 HRD+ ++NVLL A I+DFGL+ A ++ THG+ ++ APE Sbjct: 146 DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKS--AGDTHGQVGTRRYMAPE 203 Query: 543 CINY-----YKFSSKSDVWSFGVLMWEAFSYG----------QKPYRGMKGSE------V 581 + + D+++ G+++WE S P+ G Sbjct: 204 VLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQ 263 Query: 582 TAMLEKGERMGCPAGCPRE-----MYDLMNLCWTYDVENRPGFAAVELRL 626 ++ K +R + + + + CW +D E R V R+ Sbjct: 264 EVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERI 313 >5C01-A nrPDB Length = 342 Score = 162 bits (410), Expect = 4e-40, Method: Composition-based stats. Identities = 74/314 (23%), Positives = 127/314 (40%), Gaps = 48/314 (15%) Query: 349 ESPYADPEEIRPKEVYLDRKLLTLEDKE--LGSGNFGTVKKGYYQMKKVVK--------- 397 A P + ++ R + LG G V +G +++ Sbjct: 36 RGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDE 95 Query: 398 -------------TVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC-EAES 443 V +K+L +D AL A++M Q+ + ++ + G+C Sbjct: 96 DPLVPGRDRGQELRVVLKVLDPSHHDIALA--FYETASLMSQVSHTHLAFVHGVCVRGPE 153 Query: 444 WMLVMEMAELGPLNKYLQQ-NRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLL 502 ++V E E GPL+ +L++ HV + + Q++ + YLE N VH ++ RN+LL Sbjct: 154 NIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILL 213 Query: 503 V-------TQHYAKISDFGLS-KALRADENYYKAQTHGKWPVKWYAPECI--NYYKFSSK 552 T + K+SD G+ AL +E + + W APEC+ S+ Sbjct: 214 ARLGLAEGTSPFIKLSDPGVGLGALSREERVER--------IPWLAPECLPGGANSLSTA 265 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYD 612 D W FG + E G+ P + SE ++ R+ P+ CP+ + L + C TY+ Sbjct: 266 MDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPS-CPQ-LATLTSQCLTYE 323 Query: 613 VENRPGFAAVELRL 626 RP F + L Sbjct: 324 PTQRPSFRTILRDL 337 >5VC6-A nrPDB Length = 289 Score = 161 bits (407), Expect = 1e-39, Method: Composition-based stats. Identities = 55/282 (19%), Positives = 105/282 (37%), Gaps = 43/282 (15%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL-DNP 430 E +++GSG FG+V K ++ A+K K + L E L + Sbjct: 14 HELEKIGSGEFGSVFKCVKRLDGC--IYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHS 71 Query: 431 YIVRMIGICEAESWMLVM-EMAELGPLNKYLQQNRH----VKDKNIIELVHQVSMGMKYL 485 ++VR + ML+ E G L + +N K+ + +L+ QV G++Y+ Sbjct: 72 HVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYI 131 Query: 486 EESNFVHRDLAARNVLL-------------VTQHYA------KISDFGLSKALRADENYY 526 + VH D+ N+ + +A KI D G + + + Sbjct: 132 HSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQ--- 188 Query: 527 KAQTHGKWPVKWYAPECINY-YKFSSKSDVWSFGVLMWEAFSYGQKPYR--GMKGSEVTA 583 + ++ A E + Y K+D+++ + + + G +P G + E Sbjct: 189 ----VEEGDSRFLANEVLQENYTHLPKADIFALALTV--VCAAGAEPLPRNGDQWHE--- 239 Query: 584 MLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELR 625 + +G P +E +L+ + D E RP A+ Sbjct: 240 -IRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKH 280 >4WOV-A nrPDB Length = 317 Score = 160 bits (405), Expect = 2e-39, Method: Composition-based stats. Identities = 71/284 (25%), Positives = 120/284 (42%), Gaps = 46/284 (16%) Query: 377 LGSGNFGTVKKGYYQMKKVVK----------------------TVAVKILKNEANDPALK 414 LG G V +G +++ V +K+L +D AL Sbjct: 43 LGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALA 102 Query: 415 DELLAEANVMQQLDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQ-NRHVKDKNII 472 A++M Q+ + ++ + G+C ++V E E GPL+ +L++ HV + Sbjct: 103 --FYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKM 160 Query: 473 ELVHQVSMGMKYLEESNFVHRDLAARNVLLV-------TQHYAKISDFGLS-KALRADEN 524 + Q++ + YLE N VH ++ RN+LL T + K+SD G+ AL +E Sbjct: 161 VVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREER 220 Query: 525 YYKAQTHGKWPVKWYAPECI--NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVT 582 + + W APEC+ S+ D W FG + E G+ P + SE Sbjct: 221 VER--------IPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKE 272 Query: 583 AMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 626 ++ R+ P+ CP+ + L + C TY+ RP F + L Sbjct: 273 HFYQRQHRLPEPS-CPQ-LATLTSQCLTYEPTQRPSFRTILRDL 314 >5IKW-A nrPDB Length = 310 Score = 160 bits (404), Expect = 2e-39, Method: Composition-based stats. Identities = 53/275 (19%), Positives = 104/275 (37%), Gaps = 30/275 (10%) Query: 367 RKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQ 426 R +TLE + L G F TV A+K + N+ + E +M++ Sbjct: 13 RHQVTLE-ESLAEGGFSTVFLVRTHG---GIRCALKRM--YVNNMPDLNVCKREITIMKE 66 Query: 427 LD-NPYIVRMIGI----CEAESW--MLVMEMAELGPLNKYLQQN--RHVKDKNIIELVHQ 477 L + IV + W +++ME G + + + + ++++ Sbjct: 67 LSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCD 126 Query: 478 VSMGMKYLEESN--FVHRDLAARNVLLVTQHYAKISDFGLSKA-----LRADENYYKAQT 530 + L + +HRDL N+LL + DFG + + N + + Sbjct: 127 TCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEI 186 Query: 531 HGKWPVKWYAPECIN---YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 + + APE IN ++K+D+W+ G L+++ + P+ G A+ + Sbjct: 187 KKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYK-LCFFTLPF----GESQVAICDG 241 Query: 588 GERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAV 622 + + R ++ L+ D E+RP V Sbjct: 242 NFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQV 276 >4XHH-A nrPDB Length = 403 Score = 157 bits (397), Expect = 1e-38, Method: Composition-based stats. Identities = 61/272 (22%), Positives = 112/272 (41%), Gaps = 23/272 (8%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 +++GSG+FG + G + + VA+++ + P L E + + P+I Sbjct: 12 GRKIGSGSFGDIYHGTNLIS--GEEVAIRLESIRSRHPQLDYESRVYKYLSGGVGIPFI- 68 Query: 434 RMIGICEAESWMLVMEMA--ELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFV 491 R G E E +V+++ L L Y +R K +I L Q+ ++Y+ +F+ Sbjct: 69 RWFG-REGEYNAMVIDLLGPSLEDLFNY--CHRKFSFKTVIMLALQMICRVQYIHGRSFI 125 Query: 492 HRDLAARNVLLV---TQHYAKISDFGLSKALRADENY----YKAQTHGKWPVKWYAPECI 544 HRD+ N L+ + DFGLSK R + Y+ ++ + Sbjct: 126 HRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTH 185 Query: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKG----SEVTAMLEKGERMGCPAGC--- 597 + S + D+ S G ++ F G P++G+K + +LEK + C Sbjct: 186 LGIEQSRRDDLESLGYML-IYFCKGSLPWQGLKATTKKQKYDRILEKKLCISVETLCAGL 244 Query: 598 PREMYDLMNLCWTYDVENRPGFAAVELRLRNY 629 P E + MN C + RP + + ++ Sbjct: 245 PLEFSEYMNYCRNLKFDERPDYLYLARLFKDL 276 >4CRL-A nrPDB Length = 406 Score = 155 bits (391), Expect = 7e-38, Method: Composition-based stats. Identities = 46/259 (17%), Positives = 94/259 (36%), Gaps = 30/259 (11%) Query: 362 EVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEA 421 E L E ++G G +G V K + K K A+K ++ + E Sbjct: 15 ERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSAC----REI 70 Query: 422 NVMQQLDNPYIVRMIGIC---EAESWMLVMEMAELGPLNKYLQQNR---------HVKDK 469 ++++L +P ++ + + L+ + AE L ++ +R + Sbjct: 71 ALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEH-DLWHIIKFHRASKANKKPVQLPRG 129 Query: 470 NIIELVHQVSMGMKYLEESNFVHRDLAARNVLL----VTQHYAKISDFGLSKALRADENY 525 + L++Q+ G+ YL + +HRDL N+L+ + KI+D G ++ + Sbjct: 130 MVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKP 189 Query: 526 YKAQTHGKWPVKWYAPECINY-YKFSSKSDVWSFGVLMWEAFSYGQKPYR-------GMK 577 + APE + ++ D+W+ G + E + + + Sbjct: 190 LADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTS-EPIFHCRQEDIKTSN 248 Query: 578 GSEVTAMLEKGERMGCPAG 596 + MG PA Sbjct: 249 PYHHDQLDRIFNVMGFPAD 267 >6DC0-A nrPDB Length = 292 Score = 153 bits (386), Expect = 3e-37, Method: Composition-based stats. Identities = 37/211 (17%), Positives = 85/211 (40%), Gaps = 9/211 (4%) Query: 428 DNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 487 + I ++ + E+ V + G ++ Y++ + ++++ L Q+ + + + Sbjct: 56 SHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQ 115 Query: 488 SNFVHRDLAARNVLLVTQHYAKISDFGLS-KALRADENYYKAQTHGKWPVKWYAPECINY 546 S V DL R + T+ ++ L + E+ + HG + +PE +N Sbjct: 116 SAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGC--PAYVSPEILNT 173 Query: 547 YK-FSSK-SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDL 604 +S K +DVWS GV+++ G+ P+ S + + + +G+ P + L Sbjct: 174 TGTYSGKAADVWSLGVMLYTLL-VGRYPFHDSDPSALFSKIRRGQFC-IPEHISPKARCL 231 Query: 605 MNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 + + R + L ++ V+ Sbjct: 232 IRSLLRREPSERLTAPEIL--LHPWFESVLE 260 >6O6Q-A nrPDB Length = 335 Score = 152 bits (384), Expect = 4e-37, Method: Composition-based stats. Identities = 55/340 (16%), Positives = 126/340 (37%), Gaps = 70/340 (20%) Query: 346 EVYESPYADPEEIRPKEVYLDRKLLTLE---------DKELGSGNFGTVKKGYYQMKKVV 396 + YAD +P+ + D L ++ ++LG G + V G K+ Sbjct: 10 QSVSRVYADVLSTKPQSYW-DYDDLNIKWNPQENYEILRKLGRGKYSEVFLGIDLEKR-- 66 Query: 397 KTVAVKILKNEANDPALKDELLAEANVMQQL-DNPYIVRMIGIC---EAESWMLVMEMAE 452 + V +K+LK P + ++ E ++++ L D P I+ M+ + ++++ L+ E Sbjct: 67 EKVVIKVLK-----PVKRKKIKREISILKNLVDGPNIIAMLDVVREPQSKTPGLIFEHIN 121 Query: 453 LGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHY-AKIS 511 D +I ++++ + Y +HRD+ NV++ ++ Sbjct: 122 NIDFRSLY---PTFTDYDIRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLI 178 Query: 512 DFGLSKALRADENYYKAQTHGKWPVKWY-APECINYYK-FSSKSDVWSFGVLMWEAFSYG 569 D+GL++ Y + + +++ PE + Y+ + D+WSFG ++ Sbjct: 179 DWGLAEYYHPGTEY-----NVRVASRYFKGPELLVDYRLYDYSLDMWSFGCMLASMVFMK 233 Query: 570 QKPYRGMKGSEVTAMLEK----------------------------GERMGCP------- 594 + + G ++ + + +R Sbjct: 234 EPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNISLGEEYEDIGYYNKRQWVRFMNENNK 293 Query: 595 AGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVV 634 +E DL++ YD + R + +++ Y+D + Sbjct: 294 DLVSQEFLDLIDRLLRYDHQERLTA---KEAMKHAYFDPI 330 >5CEK-A nrPDB Length = 263 Score = 152 bits (384), Expect = 5e-37, Method: Composition-based stats. Identities = 37/211 (17%), Positives = 85/211 (40%), Gaps = 9/211 (4%) Query: 428 DNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 487 + I ++ + E+ V + G ++ Y++ + ++++ L Q+ + + + Sbjct: 59 SHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQ 118 Query: 488 SNFVHRDLAARNVLLVTQHYAKISDFGLS-KALRADENYYKAQTHGKWPVKWYAPECINY 546 S V DL R + T+ ++ L + E+ + HG + +PE +N Sbjct: 119 SAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGC--PAYVSPEILNT 176 Query: 547 YK-FSSK-SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDL 604 +S K +DVWS GV+++ G+ P+ S + + + +G+ P + L Sbjct: 177 TGTYSGKAADVWSLGVMLYTLL-VGRYPFHDSDPSALFSKIRRGQFC-IPEHISPKARCL 234 Query: 605 MNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 + + R + L ++ V+ Sbjct: 235 IRSLLRREPSERLTAPEIL--LHPWFESVLE 263 >3QD2-B nrPDB Length = 332 Score = 150 bits (378), Expect = 2e-36, Method: Composition-based stats. Identities = 48/321 (14%), Positives = 99/321 (30%), Gaps = 82/321 (25%) Query: 378 GSGNFGTVKKGYYQMKKVVKTVAVKILKNEAND--------------------------- 410 G G FG V + ++ A+K ++ + Sbjct: 15 GRGGFGVVFEAKNKVDDCN--YAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNA 72 Query: 411 -----PALKDELLAEA------------------------NVMQQLDNPYIVRMIGICEA 441 P E + E M V + Sbjct: 73 WLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVGQLQPSSP 132 Query: 442 ESWMLV-MEMAELGPLNKYLQQNRHVKDKN---IIELVHQVSMGMKYLEESNFVHRDLAA 497 + ++ + M++ L ++ + ++D+ + + Q++ +++L +HRDL Sbjct: 133 KVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGLMHRDLKP 192 Query: 498 RNVLLVTQHYAKISDFGLSKALRADENY---------YKAQTHGKWPVKWYAPECINYYK 548 N+ K+ DFGL A+ DE Y T + +PE I+ Sbjct: 193 SNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSPEQIHGNN 252 Query: 549 FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCP----AGCPREMYDL 604 +S K D++S G++++E Y E ++ + P P+E + + Sbjct: 253 YSHKVDIFSLGLILFELL------YSFSTQMERVRIITDVRNLKFPLLFTQKYPQE-HMM 305 Query: 605 MNLCWTYDVENRPGFAAVELR 625 + + RP + Sbjct: 306 VQDMLSPSPTERPEATDIIEN 326 >5J0A-A nrPDB Length = 300 Score = 150 bits (378), Expect = 2e-36, Method: Composition-based stats. Identities = 61/289 (21%), Positives = 108/289 (37%), Gaps = 39/289 (13%) Query: 375 KELGSGNFGT---VKKGYYQMKKVVKT-VAVKILKNEAND---PALKDELLAEANVMQQL 427 ++LG FGT V + + + AVK + ND + L+ EA +++ L Sbjct: 15 QKLG---FGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSL 71 Query: 428 DNPYIVRMIGICEAE--SWMLVMEMAELGPLNKYLQQN-----RHVKDKNIIELVHQVSM 480 +P IV EA S L ME LN +++ I+++ ++ Sbjct: 72 HHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMAR 131 Query: 481 GMKYLE-ESNFVHRDLAARNVLLVTQ-HYAKISDFGLSKALRADENYYKAQTHGKWPVKW 538 G+KYL E +H D+ + NV++ KI D G+S L + + W Sbjct: 132 GLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEPW 191 Query: 539 YAPECINYYK-FSSKSDVWSFGVLMWEAFSYGQKP--------------YRGMKGSEVTA 583 E + + K+D+++FG+ +WE + P + + Sbjct: 192 KPKEAVEENGVITDKADIFAFGLTLWEMMTL-SIPHINLSNDDDDEDKTFDESDFDDEAY 250 Query: 584 MLEKGERMGCPAGCPRE----MYDLMNLCWTYDVENRPGFAAVELRLRN 628 G R E + +L ++C D ++RP A + L Sbjct: 251 YAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVEALET 299 >2LQW-A nrPDB Length = 303 Score = 150 bits (378), Expect = 2e-36, Method: Composition-based stats. Identities = 50/208 (24%), Positives = 83/208 (39%), Gaps = 19/208 (9%) Query: 3 SSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAH 62 SS DS++ ++ G ++R+EA+ L G G++L+R S G + LSV+ + Sbjct: 2 SSARFDSSDRSAWYMGPVSRQEAQTRL--QGQRHGMFLVRDSSTCPGDYVLSVSENSRVS 59 Query: 63 HYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKP-FNRPQGVQPKTGPFE 121 HY I N + I PA L Y D + P + P Sbjct: 60 HYIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPMGSVSAPNLP 119 Query: 122 DLKENLIREYVKQTWNLQGQAL--------EQAIISQKPQLEKLIATTAHEKMPWFHGKI 173 ++NL EYV+ ++ G E +I +KP+ + A ++ G I Sbjct: 120 TAEDNL--EYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRV----GMI 173 Query: 174 SREESEQIVLIGSKTNGKFLIRARDNNG 201 E++V S +GK R ++ G Sbjct: 174 PVPYVEKLV--RSSPHGKHGNRNSNSYG 199 Score = 80.8 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 35/191 (18%), Positives = 67/191 (35%), Gaps = 14/191 (7%) Query: 161 TAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDN-NGSYALCLLHEGKVLHYRID 219 + ++ W+ G +SR+E++ + + +G FL+R G Y L + +V HY I+ Sbjct: 7 DSSDRSAWYMGPVSRQEAQT--RLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIIN 64 Query: 220 KDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGS 279 + I + ++FD L L+E Y L P + + + P LP + Sbjct: 65 SLPNRRFKIGD-QEFDHLPALLEFYKIHYLD-TTTLIEPAPRYPSPPMGSVSA-PNLPTA 121 Query: 280 HPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQRE 339 + PG+ + + P E + D Sbjct: 122 EDN--------LEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMI 173 Query: 340 ALPMDTEVYES 350 +P ++ S Sbjct: 174 PVPYVEKLVRS 184 >2QLU-A nrPDB Length = 314 Score = 149 bits (376), Expect = 4e-36, Method: Composition-based stats. Identities = 60/292 (20%), Positives = 108/292 (36%), Gaps = 53/292 (18%) Query: 379 SGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGI 438 G FG V K + VAVKI + + E + + +++ I Sbjct: 25 RGRFGCVWKAQL----MNDFVAVKIFPLQDKQSWQSE---REIFSTPGMKHENLLQFIAA 77 Query: 439 CEAESWM-----LVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE------ 487 + S + L+ + G L YL+ N + + + +S G+ YL E Sbjct: 78 EKRGSNLEVELWLITAFHDKGSLTDYLKGN-IITWNELCHVAETMSRGLSYLHEDVPWCR 136 Query: 488 -----SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGK-WPVKWYAP 541 + HRD ++NVLL + A ++DFGL+ + THG+ ++ AP Sbjct: 137 GEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKP--PGDTHGQVGTRRYMAP 194 Query: 542 ECINY-----YKFSSKSDVWSFGVLMWEAFSYGQ----------KPY-----RGMKGSEV 581 E + + D+++ G+++WE S + P+ + E+ Sbjct: 195 EVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEEL 254 Query: 582 TA-MLEKGERMGCPAGCPRE--MYDL---MNLCWTYDVENRPGFAAVELRLR 627 ++ K R + + L + CW +D E R VE R+ Sbjct: 255 QEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVS 306 >5UNP-A nrPDB Length = 369 Score = 149 bits (375), Expect = 4e-36, Method: Composition-based stats. Identities = 53/240 (22%), Positives = 94/240 (39%), Gaps = 40/240 (16%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL-----DNP 430 LG G FG V + + VA+KI+KN K+ E NV++++ DN Sbjct: 41 TLGEGTFGRVVQCVDHRRG-GARVALKIIKNV---EKYKEAARLEINVLEKINEKDPDNK 96 Query: 431 YI-VRMIGICE-AESWMLVMEMAELGPLNKYLQQNRHVKDK--NIIELVHQVSMGMKYLE 486 + V+M + + E+ L +L+ N ++ + + Q+ +K+L Sbjct: 97 NLCVQMFDWFDYHGHMCISFELLGLST-FDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLH 155 Query: 487 ESNFVHRDLAARNVLLVTQHY-------------------AKISDFGLSKALRADENYYK 527 ++ H DL N+L V Y ++ DFG + + Sbjct: 156 DNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIV 215 Query: 528 AQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK 587 + + APE I +S DVWS G +++E + G ++ E AM+E+ Sbjct: 216 S------TRHYRAPEVILELGWSQPCDVWSIGCIIFEYY-VGFTLFQTHDNREHLAMMER 268 >4XHL-A nrPDB Length = 394 Score = 147 bits (371), Expect = 1e-35, Method: Composition-based stats. Identities = 58/272 (21%), Positives = 111/272 (40%), Gaps = 23/272 (8%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 +++GSG+FG + G + + VA+++ + P L E + + P+I Sbjct: 12 GRKIGSGSFGDIYHGTNLIS--GEEVAIRLESIRSRHPQLDYESRVYRYLSGGVGIPFI- 68 Query: 434 RMIGICEAESWMLVMEMA--ELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFV 491 R G E E +V+++ L L Y +R K +I L Q+ ++Y+ +F+ Sbjct: 69 RWFG-REGEYNAMVIDLLGPSLEDLFNY--CHRRFSFKTVIMLALQMFCRIQYIHGRSFI 125 Query: 492 HRDLAARNVLLV---TQHYAKISDFGLSKALRADENY----YKAQTHGKWPVKWYAPECI 544 HRD+ N L+ + DFGLSK R + Y+ ++ + Sbjct: 126 HRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTH 185 Query: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKG----SEVTAMLEKGERMGCPAGC--- 597 + S + D+ S G ++ F G P++G+K + ++EK + C Sbjct: 186 LGIEQSRRDDLESLGYVL-IYFCKGSLPWQGLKATTKKQKYDRIMEKKLNVSVETLCSGL 244 Query: 598 PREMYDLMNLCWTYDVENRPGFAAVELRLRNY 629 P E + M C + +P + + ++ Sbjct: 245 PLEFQEYMAYCKNLKFDEKPDYLFLARLFKDL 276 >4IAN-A nrPDB Length = 358 Score = 145 bits (367), Expect = 4e-35, Method: Composition-based stats. Identities = 44/218 (20%), Positives = 92/218 (42%), Gaps = 22/218 (10%) Query: 378 GSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNP------Y 431 G G F V + + + VAVKI++N + ++ L E +++L++ + Sbjct: 39 GQGVFSNVVRARDNAR-ANQEVAVKIIRN---NELMQKTGLKELEFLKKLNDADPDDKFH 94 Query: 432 IVRMI-GICEAESWMLVMEMAELGPLNKYLQQNRH---VKDKNIIELVHQVSMGMKYLEE 487 +R+ + LV E + L + L++ + K + Q+ + +K L+ Sbjct: 95 CLRLFRHFYHKQHLCLVFEPLSM-NLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKR 153 Query: 488 SNFVHRDLAARNVLLVTQHYA-KISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY 546 N +H D+ N+L+ K+ DFG + + ++ T + APE I Sbjct: 154 CNILHADIKPDNILVNESKTILKLCDFGSASHVADND-----ITPYLVSRFYRAPEIIIG 208 Query: 547 YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAM 584 + D+WS G ++E ++ G+ + G + + + Sbjct: 209 KSYDYGIDMWSVGCTLYELYT-GKILFPGKTNNHMLKL 245 >3RAW-A nrPDB Length = 381 Score = 144 bits (364), Expect = 1e-34, Method: Composition-based stats. Identities = 55/328 (16%), Positives = 113/328 (34%), Gaps = 91/328 (27%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL---DNPYIV 433 LG G FG V + + + VA+KI++N ++ E NV++++ D Sbjct: 59 LGEGTFGKVVECLDHARGKSQ-VALKIIRNVG---KYREAARLEINVLKKIKEKDKEN-- 112 Query: 434 RMIGICEAE------SWMLVMEMAELGPLNKYLQQN--RHVKDKNIIELVHQVSMGMKYL 485 + + + ++ + E+ ++L++N + ++ + +Q+ +++L Sbjct: 113 KFLCVLMSDWFNFHGHMCIAFELLGKNT-FEFLKENNFQPYPLPHVRHMAYQLCHALRFL 171 Query: 486 EESNFVHRDLAARNVLLVT-------------------QHYAKISDFGLSKALRADENYY 526 E+ H DL N+L V +++DFG + + Sbjct: 172 HENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATF------DH 225 Query: 527 KAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLE 586 + T + PE I ++ DVWS G +++E + G ++ + E M+E Sbjct: 226 EHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYY-RGFTLFQTHENREHLVMME 284 Query: 587 KGERMGCPA-------------------------------GCPR-------------EMY 602 K P+ C +++ Sbjct: 285 KILG-PIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLF 343 Query: 603 DLMNLCWTYDVENRPGFAAVELRLRNYY 630 DLM +D R A E L ++ Sbjct: 344 DLMRRMLEFDPAQRITLA--EALLHPFF 369 >2WTK-B nrPDB Length = 373 Score = 140 bits (354), Expect = 1e-33, Method: Composition-based stats. Identities = 51/315 (16%), Positives = 105/315 (33%), Gaps = 68/315 (21%) Query: 376 ELGSGNFG---TVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 +G G F TV Y K + V V+ + EA + L E +V + ++P I Sbjct: 16 VIGKG-FEDLMTVNLARY--KPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNI 72 Query: 433 VRMIGICEAES-WMLVMEMAELGPLNKYLQQN--RHVKDKNIIELVHQVSMGMKYLEESN 489 V A++ +V G + + + + I ++ V + Y+ Sbjct: 73 VPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMG 132 Query: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWP------VKWYAPEC 543 +VHR + A ++L+ +S GL L + + + +P + W +PE Sbjct: 133 YVHRSVKASHILISVDGKVYLS--GLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEV 190 Query: 544 INY--YKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERM---------- 591 + + +KSD++S G+ E + G P++ M +++ G Sbjct: 191 LQQNLQGYDAKSDIYSVGITACE-LANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPA 249 Query: 592 ------------------------GCPAG-----------CPREMYDLMNLCWTYDVENR 616 P+ + + C + + R Sbjct: 250 EELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDAR 309 Query: 617 PGFAAVELRLRNYYY 631 P + + L + ++ Sbjct: 310 PSASTL---LNHSFF 321 >5XVU-A nrPDB Length = 332 Score = 140 bits (353), Expect = 2e-33, Method: Composition-based stats. Identities = 49/252 (19%), Positives = 100/252 (39%), Gaps = 32/252 (12%) Query: 352 YADPEEIRPKEVYLDRKLLTLE---------DKELGSGNFGTVKKGYYQMKKVVKTVAVK 402 YAD +PKE Y D L L+ K++G G + V GY + + A Sbjct: 6 YADVNIHKPKEYY-DYDNLELQWNKPNRYEIMKKIGRGKYSEVFNGYD--TECNRPCA-- 60 Query: 403 ILKNEANDPALKDELLAEANVMQQLDN-PYIVRMIGICEA---ESWMLVMEMAELGPLNK 458 + P K ++ E ++Q L+ P I++++ I + ++ L+ E Sbjct: 61 ---IKVLKPVKKKKIKREIKILQNLNGGPNIIKLLDIVKDPVTKTPSLIFEYINNIDFKT 117 Query: 459 YLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV-TQHYAKISDFGLSK 517 + DK+I ++Q+ + Y +HRD+ N+++ ++ +GL++ Sbjct: 118 LYPK---FTDKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAE 174 Query: 518 ALRADENYYKAQTHGKWPVKWY-APE-CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG 575 + Y + + ++Y PE I+ + D+WS G ++ + + G Sbjct: 175 FYHPGQEY-----NVRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCG 229 Query: 576 MKGSEVTAMLEK 587 + + K Sbjct: 230 HDNYDQLVKIAK 241 >3LLT-A nrPDB Length = 360 Score = 138 bits (349), Expect = 5e-33, Method: Composition-based stats. Identities = 55/251 (21%), Positives = 101/251 (40%), Gaps = 48/251 (19%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI-- 432 +++G G FG V + K K AVK+++N EA++++++ N I Sbjct: 41 RKMGDGTFGRVLLCQHIDNK--KYYAVKVVRNI---KKYTRSAKIEADILKKIQNDDINN 95 Query: 433 ---VRMIG-ICEAESWMLVMEMAELG-PLNKYLQQNRH--VKDKNIIELVHQVSMGMKYL 485 V+ G + L+ E LG L + + +N + ++I ++ + YL Sbjct: 96 NNIVKYHGKFMYYDHMCLIFE--PLGPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYL 153 Query: 486 EESNFVHRDLAARNVLLVTQHY-------------------------AKISDFGLSKALR 520 + + H DL N+LL ++ K+ DFG + Sbjct: 154 RKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFG-CATFK 212 Query: 521 ADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSE 580 +D + T ++ APE I + SD+WSFG ++ E ++ G +R + E Sbjct: 213 SDYHGSIINTR-----QYRAPEVILNLGWDVSSDMWSFGCVLAELYT-GSLLFRTHEHME 266 Query: 581 VTAMLEKGERM 591 AM+E + Sbjct: 267 HLAMMESIIQP 277 >5L2Q-C nrPDB Length = 320 Score = 138 bits (349), Expect = 6e-33, Method: Composition-based stats. Identities = 52/284 (18%), Positives = 104/284 (36%), Gaps = 48/284 (16%) Query: 387 KGYYQMKKVVKTVAVKILKNEAN---------DPALKDELLAEANVMQQLD-NPYIVRMI 436 + + +KIL E + K L E +++ L +V Sbjct: 32 QCLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHH 91 Query: 437 GICEAES-------------------WMLVMEMA----------ELGPLNKYLQQNRHVK 467 G+ + + LV++ +L L Y+ + + + Sbjct: 92 GLFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLS 151 Query: 468 DKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQ-HYAKISDFGLSKALRADENYY 526 ++ + + + V ++ L + N VHRDL N++L + H I++F L K L ++ + Sbjct: 152 ERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLL 211 Query: 527 KAQTHGKWPVKWYAPECINYYKF-SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAML 585 K Q + + +P+ ++ + SD+W+ GV+++ YGQ P+ E+ + Sbjct: 212 KDQ---RGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTML-YGQFPFYDSIPQELFRKI 267 Query: 586 EKGERMGCPAG--CPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 + E P L+ D + R A V L Sbjct: 268 KAAE-YTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLEALS 310 >2CMW-A nrPDB Length = 310 Score = 137 bits (345), Expect = 2e-32, Method: Composition-based stats. Identities = 57/275 (20%), Positives = 105/275 (38%), Gaps = 24/275 (8%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 K++G GNFG ++ G + VA+K+ ++ P L E + + V Sbjct: 5 GKKIGCGNFGELRLGKNL--YTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQV 62 Query: 434 RMIGICEAESWMLVMEMA--ELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFV 491 G C + +V+E+ L L +R K ++ + Q+ M+Y+ N + Sbjct: 63 YYFGPC-GKYNAMVLELLGPSLEDLFDL--CDRTFTLKTVLMIAIQLLSRMEYVHSKNLI 119 Query: 492 HRDLAARNVLL-----VTQHYAKISDFGLSKALRADENY----YKAQTHGKWPVKWYAPE 542 +RD+ N L+ +H I DFGL+K E Y+ ++ + Sbjct: 120 YRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSIN 179 Query: 543 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKG---SEVTAMLEKGER-MGCPAGC- 597 + S + D+ + G M+ F G P++G+K E + +R A C Sbjct: 180 THLGKEQSRRDDLEALG-HMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCE 238 Query: 598 --PREMYDLMNLCWTYDVENRPGFAAVELRLRNYY 630 P EM + D +P + + + + Sbjct: 239 NFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLF 273 >2PVN-A nrPDB Length = 352 Score = 136 bits (342), Expect = 3e-32, Method: Composition-based stats. Identities = 42/251 (16%), Positives = 92/251 (36%), Gaps = 30/251 (11%) Query: 352 YADPEEIRPKEVYLDRKLLTLE---------DKELGSGNFGTVKKGYYQMKKVVKTVAVK 402 YAD +RPKE + D + LT++ +++G G + V +G K Sbjct: 27 YADVNVLRPKEYW-DYEALTVQWGEQDDYEVVRKVGRGKYSEVFEGINVNNNE------K 79 Query: 403 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAE---SWMLVMEMAELGPLNKY 459 + K + P IV+++ I + + L+ E + Sbjct: 80 CIIKILKPVKKKKIKREIKILQNLCGGPNIVKLLDIVRDQHSKTPSLIFEYVNN---TDF 136 Query: 460 LQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHY-AKISDFGLSKA 518 + D +I ++++ + Y +HRD+ NV++ + ++ D+GL++ Sbjct: 137 KVLYPTLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEF 196 Query: 519 LRADENYYKAQTHGKWPVKWY-APECINY-YKFSSKSDVWSFGVLMWEAFSYGQKPYRGM 576 + Y + + +++ PE + + D+WS G + + + G Sbjct: 197 YHPGKEY-----NVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGH 251 Query: 577 KGSEVTAMLEK 587 + + K Sbjct: 252 DNHDQLVKIAK 262 >1CSN-A nrPDB Length = 298 Score = 135 bits (339), Expect = 8e-32, Method: Composition-based stats. Identities = 52/272 (19%), Positives = 104/272 (38%), Gaps = 25/272 (9%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 + +G G+FG + +G + + VA+K ++ P L+DE + P + Sbjct: 15 GRRIGEGSFGVIFEGTNLLNN--QQVAIKFEPRRSDAPQLRDEYRTYKLLAGCTGIPNV- 71 Query: 434 RMIGICEAESWMLVMEMAELGPLNKYLQ-QNRHVKDKNIIELVHQVSMGMKYLEESNFVH 492 E +LV+++ L L R K + Q+ ++ + E + V+ Sbjct: 72 -YYFGQEGLHNVLVIDLL-GPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHEKSLVY 129 Query: 493 RDLAARNVLLVTQHY-----AKISDFGLSKALRADENY----YKAQTHGKWPVKWYAPEC 543 RD+ N L+ + + DFG+ K R Y+ + + ++ + Sbjct: 130 RDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARYMSINT 189 Query: 544 INYYKFSSKSDVWSFG-VLMWEAFSYGQKPYRGMKGSEVTAMLEKG--ERMGCP-----A 595 + S + D+ + G V M+ F G P++G+K + E+ ++ P A Sbjct: 190 HLGREQSRRDDLEALGHVFMY--FLRGSLPWQGLKAATNKQKYERIGEKKQSTPLRELCA 247 Query: 596 GCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 G P E Y M+ + P + ++ Sbjct: 248 GFPEEFYKYMHYARNLAFDATPDYDYLQGLFS 279 >4MD7-E nrPDB Length = 391 Score = 133 bits (336), Expect = 2e-31, Method: Composition-based stats. Identities = 48/298 (16%), Positives = 112/298 (37%), Gaps = 36/298 (12%) Query: 335 GPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKK 394 R ++T + + D +L+ ++LG G + V + Sbjct: 7 SRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLV----RKLGRGKYSEVFEAINITNN 62 Query: 395 VVKTVAVKILKNEANDPALKDELLAEANVMQQLDN-PYIVRMIGICEAE---SWMLVMEM 450 + P K ++ E +++ L P I+ + I + + LV E Sbjct: 63 EKVV-------VKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEH 115 Query: 451 AELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHY-AK 509 + Q + D +I ++++ + Y +HRD+ NV++ +H + Sbjct: 116 VNNTDFKQLYQ---TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLR 172 Query: 510 ISDFGLSKALRADENYYKAQTHGKWPVKWY-APECI-NYYKFSSKSDVWSFGVLMWEAFS 567 + D+GL++ + Y + + +++ PE + +Y + D+WS G ++ Sbjct: 173 LIDWGLAEFYHPGQEY-----NVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF 227 Query: 568 YGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELR 625 + + G + ++ + +G ++YD ++ Y++E P F + R Sbjct: 228 RKEPFFHGHDNYD--QLVRIAKVLGT-----EDLYDYID---KYNIELDPRFNDILGR 275 >6AMW-A nrPDB Length = 255 Score = 133 bits (335), Expect = 2e-31, Method: Composition-based stats. Identities = 34/120 (28%), Positives = 62/120 (51%), Gaps = 7/120 (5%) Query: 7 ADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTI 66 +S ++ G ++R AE YL+ G+ +G +L+R+S + G ++S+ + + +HY I Sbjct: 138 VNSLEKHSWYHGPVSRNAAE-YLLSSGI-NGSFLVRESESSPGQRSISLRYEGRVYHYRI 195 Query: 67 ERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPF---NRPQ--GVQPKTGPFE 121 +G ++ + A+L H+HS +DGL+ L P N+P GV P +E Sbjct: 196 NTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWE 255 Score = 123 bits (308), Expect = 3e-28, Method: Composition-based stats. Identities = 44/123 (35%), Positives = 65/123 (52%), Gaps = 12/123 (9%) Query: 160 TTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDN-NGSYALCLLHEGKVLHYRI 218 + EK W+HG +SR +E L+ S NG FL+R ++ G ++ L +EG+V HYRI Sbjct: 138 VNSLEKHSWYHGPVSRNAAE--YLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRI 195 Query: 219 DKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPG 278 + GKL + +F+TL +LV H+S ADGL+ L P K +P + G Sbjct: 196 NTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPK---------RNKPTVYG 246 Query: 279 SHP 281 P Sbjct: 247 VSP 249 >2C47-A nrPDB Length = 313 Score = 132 bits (331), Expect = 6e-31, Method: Composition-based stats. Identities = 55/276 (19%), Positives = 102/276 (36%), Gaps = 27/276 (9%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIV 433 K++G GNFG ++ G + VA+K+ ++ P L E + P V Sbjct: 9 GKKIGCGNFGELRLGKNL--YTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQ-V 65 Query: 434 RMIGICEAESWMLVMEMA--ELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFV 491 G C + +V+E+ L L +R K ++ + Q+ M+Y+ + + Sbjct: 66 YYFGPC-GKYNAMVLELLGPSLEDLFDL--CDRTFTLKTVLMIAIQLITRMEYVHTKSLI 122 Query: 492 HRDLAARNVLLVTQHY-----AKISDFGLSKALRADENY----YKAQTHGKWPVKWYAPE 542 +RD+ N L+ I DFGL+K E Y+ ++ + Sbjct: 123 YRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSIN 182 Query: 543 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKG---SEVTAMLEKGERMGCP----- 594 + S + D+ + G M+ F G P++G+K E + +R P Sbjct: 183 THLGKEQSRRDDLEALG-HMFMYFLRGSLPWQGLKADTLKERYQKIGDTKR-ATPIEVLC 240 Query: 595 AGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYY 630 P EM + D +P + + + + Sbjct: 241 ENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLF 276 >6EII-A nrPDB Length = 352 Score = 132 bits (331), Expect = 7e-31, Method: Composition-based stats. Identities = 48/298 (16%), Positives = 112/298 (37%), Gaps = 36/298 (12%) Query: 335 GPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKK 394 R ++T + + D +L+ ++LG G + V + Sbjct: 30 SRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLV----RKLGRGKYSEVFEAINITNN 85 Query: 395 VVKTVAVKILKNEANDPALKDELLAEANVMQQLDN-PYIVRMIGICEAE---SWMLVMEM 450 + P K ++ E +++ L P I+ + I + + LV E Sbjct: 86 EKVV-------VKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEH 138 Query: 451 AELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHY-AK 509 + Q + D +I ++++ + Y +HRD+ NV++ +H + Sbjct: 139 VNNTDFKQLYQ---TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLR 195 Query: 510 ISDFGLSKALRADENYYKAQTHGKWPVKWY-APECI-NYYKFSSKSDVWSFGVLMWEAFS 567 + D+GL++ + Y + + +++ PE + +Y + D+WS G ++ Sbjct: 196 LIDWGLAEFYHPGQEY-----NVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF 250 Query: 568 YGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELR 625 + + G + ++ + +G ++YD ++ Y++E P F + R Sbjct: 251 RKEPFFHGHDNYD--QLVRIAKVLGT-----EDLYDYID---KYNIELDPRFNDILGR 298 >4NT4-A nrPDB Length = 312 Score = 131 bits (330), Expect = 8e-31, Method: Composition-based stats. Identities = 54/279 (19%), Positives = 105/279 (37%), Gaps = 27/279 (9%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDN---- 429 K++G GNFG ++ G + VA+K+ ++ P L E + DN Sbjct: 17 GKKIGCGNFGELRLGKNLYNN--EHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAPDG 74 Query: 430 -PYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 P I + G C +V+E+ L + + R K ++ + Q+ ++Y+ Sbjct: 75 IPRIYHL-GTCGGRYNAMVLELLGLSLEDLFNICARKFSLKTVLMIAKQLLHRIEYVHSR 133 Query: 489 NFVHRDLAARNVLL-----VTQHYAKISDFGLSKALRADENY----YKAQTHGKWPVKWY 539 + ++RD+ N L+ + I DFGL+K + Y+ ++ Sbjct: 134 HLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGTARYM 193 Query: 540 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKG---SEVTAMLEKGERMGCP-- 594 + + S + D+ + G M+ F G P++G+K E + +R P Sbjct: 194 SINTHMGREQSRRDDLEALG-HMFMYFLRGSLPWQGLKADTLKERYQKIGDTKR-ATPIE 251 Query: 595 ---AGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYY 630 G P E + D P + + ++ + Sbjct: 252 VLCDGHPEEFATYLRYVRRLDFFETPDYDFLRRLFQDLF 290 >4BTK-A nrPDB Length = 337 Score = 131 bits (329), Expect = 1e-30, Method: Composition-based stats. Identities = 54/267 (20%), Positives = 106/267 (39%), Gaps = 22/267 (8%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLD-NPYIV 433 K++G G FG + + + + VA+K+ + K L E V+++L ++ Sbjct: 62 KKIGGGGFGEIYEAMDLL--TRENVALKV----ESAQQPKQVLKMEVAVLKKLQGKDHVC 115 Query: 434 RMIGICEAESW-MLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGMKYLEESNF 490 R IG E + +VM++ + L + + L Q+ ++ + F Sbjct: 116 RFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGF 174 Query: 491 VHRDLAARNV----LLVTQHYAKISDFGLSKALRA---DENYYKAQTHGKWPVKWYAPEC 543 +HRD+ N L T + DFGL++ D + + V++ + Sbjct: 175 LHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNA 234 Query: 544 INYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG--ERMGCPAGCPREM 601 + D+WS ++ E F+ GQ P+R +K E M+++ RM P E Sbjct: 235 HKNREMGRHDDLWSLFYMLVE-FAVGQLPWRKIKDKEQVGMIKEKYEHRMLL-KHMPSEF 292 Query: 602 YDLMNLCWTYDVENRPGFAAVELRLRN 628 + ++ + D +P + + N Sbjct: 293 HLFLDHIASLDYFTKPDYQLIMSVFEN 319 >2PMN-X nrPDB Length = 348 Score = 131 bits (329), Expect = 1e-30, Method: Composition-based stats. Identities = 54/308 (17%), Positives = 107/308 (34%), Gaps = 61/308 (19%) Query: 358 IRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALK--- 414 ++ K+ Y++ + + L G F + +K K A+K + + Sbjct: 23 VKEKDKYINDYRII---RTLNQGKFNKIILC----EKDNKFYALKKYEKSLLEKKRDFTK 75 Query: 415 ------------DELLAEANVMQQLDNPYIVRMIGICEA-ESWMLVMEMAELGPLNKY-- 459 D+ E ++ + N Y + GI + ++ E E + K+ Sbjct: 76 SNNDKISIKSKYDDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDE 135 Query: 460 ----LQQNR--HVKDKNIIELVHQVSMGMKYLE-ESNFVHRDLAARNVLLVTQHYAKISD 512 L +N + + I ++ V Y+ E N HRD+ N+L+ K+SD Sbjct: 136 YFFVLDKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSD 195 Query: 513 FGLSKALRADENYYKAQTHGKWPVKWYAPECI-NYYKF-SSKSDVWSFGVLMWEAFSYGQ 570 FG S+ + K + ++ PE N + +K D+WS G+ ++ F Y Sbjct: 196 FGESEYMVD-----KKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMF-YNV 249 Query: 571 KP----------YRGMKGSEVTAMLEKGERMGCP-----AGCPREM-----YDLMNLCWT 610 P + ++ + L++ + P + C D + L Sbjct: 250 VPFSLKISLVELFNNIRTKNIEYPLDRNHFL-YPLTNKKSTCSNNFLSNEDIDFLKLFLR 308 Query: 611 YDVENRPG 618 + R Sbjct: 309 KNPAERIT 316 >2CHL-A nrPDB Length = 351 Score = 130 bits (327), Expect = 2e-30, Method: Composition-based stats. Identities = 56/277 (20%), Positives = 104/277 (37%), Gaps = 30/277 (10%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDN-PYI 432 K++G GNFG ++ G + VA+K+ ++ P +L E +QL + I Sbjct: 35 GKKIGCGNFGELRLGKNL--YTNEYVAIKLEPMKSRAP----QLHLEYRFYKQLGSGDGI 88 Query: 433 --VRMIGICEAESWMLVMEMA--ELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 V G C + +V+E+ L L +R K ++ + Q+ M+Y+ Sbjct: 89 PQVYYFGPC-GKYNAMVLELLGPSLEDLFDL--CDRTFSLKTVLMIAIQLISRMEYVHSK 145 Query: 489 NFVHRDLAARNVLLVTQH-----YAKISDFGLSKALRADENY----YKAQTHGKWPVKWY 539 N ++RD+ N L+ I DF L+K E Y+ ++ Sbjct: 146 NLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYM 205 Query: 540 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKG---SEVTAMLEKGER-MGCPA 595 + + S + D+ + G M+ F G P++G+K E + +R Sbjct: 206 SINTHLGKEQSRRDDLEALG-HMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEV 264 Query: 596 GCP--REMYDLMNLCWTYDVENRPGFAAVELRLRNYY 630 C EM + D +P + + + + Sbjct: 265 LCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLF 301 >4NFN-A nrPDB Length = 309 Score = 129 bits (325), Expect = 3e-30, Method: Composition-based stats. Identities = 54/267 (20%), Positives = 106/267 (39%), Gaps = 22/267 (8%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLD-NPYIV 433 K++G G FG + + + + VA+K+ + K L E V+++L ++ Sbjct: 27 KKIGGGGFGEIYEAMDLL--TRENVALKV----ESAQQPKQVLKMEVAVLKKLQGKDHVC 80 Query: 434 RMIGICEAESW-MLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGMKYLEESNF 490 R IG E + +VM++ + L + + L Q+ ++ + F Sbjct: 81 RFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGF 139 Query: 491 VHRDLAARNV----LLVTQHYAKISDFGLSKALRA---DENYYKAQTHGKWPVKWYAPEC 543 +HRD+ N L T + DFGL++ D + + V++ + Sbjct: 140 LHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNA 199 Query: 544 INYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG--ERMGCPAGCPREM 601 + D+WS ++ E F+ GQ P+R +K E M+++ RM P E Sbjct: 200 HKNREMGRHDDLWSLFYMLVE-FAVGQLPWRKIKDKEQVGMIKEKYEHRMLL-KHMPSEF 257 Query: 602 YDLMNLCWTYDVENRPGFAAVELRLRN 628 + ++ + D +P + + N Sbjct: 258 HLFLDHIASLDYFTKPDYQLIMSVFEN 284 >2ABL-A nrPDB Length = 163 Score = 128 bits (321), Expect = 8e-30, Method: Composition-based stats. Identities = 28/102 (27%), Positives = 54/102 (52%), Gaps = 2/102 (1%) Query: 7 ADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTI 66 +S ++ G ++R AE YL+ G+ +G +L+R+S + G ++S+ + + +HY I Sbjct: 64 VNSLEKHSWYHGPVSRNAAE-YLLSSGI-NGSFLVRESESSPGQRSISLRYEGRVYHYRI 121 Query: 67 ERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFN 108 +G ++ + A+L H+HS +DGL+ L P Sbjct: 122 NTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAP 163 Score = 122 bits (307), Expect = 3e-28, Method: Composition-based stats. Identities = 40/102 (39%), Positives = 59/102 (57%), Gaps = 3/102 (2%) Query: 160 TTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDN-NGSYALCLLHEGKVLHYRI 218 + EK W+HG +SR +E L+ S NG FL+R ++ G ++ L +EG+V HYRI Sbjct: 64 VNSLEKHSWYHGPVSRNAAE--YLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRI 121 Query: 219 DKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQ 260 + GKL + +F+TL +LV H+S ADGL+ L P Sbjct: 122 NTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAP 163 >5X18-A nrPDB Length = 295 Score = 127 bits (319), Expect = 1e-29, Method: Composition-based stats. Identities = 50/280 (17%), Positives = 107/280 (38%), Gaps = 29/280 (10%) Query: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDN-PYI 432 K++G G+FG + +G + V VA+K + P L+D E + L+ P I Sbjct: 12 GKKIGEGSFGVLFEGTNMINGV--PVAIKFEPRKTEAPQLRD----EYKTYKILNGTPNI 65 Query: 433 VRMIGI-CEAESWMLVMEMA--ELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 E +LV+++ L L + R K ++++ Q+ ++ L + Sbjct: 66 PYAYYFGQEGLHNILVIDLLGPSLEDLFDW--CGRKFSVKTVVQVAVQMITLIEDLHAHD 123 Query: 490 FVHRDLAARNVLLVTQHY-----AKISDFGLSKALRADENY----YKAQTHGKWPVKWYA 540 ++RD+ N L+ + DFG++K R + Y+ + ++ + Sbjct: 124 LIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMS 183 Query: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGM---KGSEVTAMLEKGER----MGC 593 + S + D+ + G + + F G P++G+ + + + +R Sbjct: 184 INTHLGREQSRRDDMEALGHVFF-YFLRGHLPWQGLKAPNNKQKYEKIGEKKRSTNVYDL 242 Query: 594 PAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDV 633 G P + + + + E P + L + D+ Sbjct: 243 AQGLPVQFGRYLEIVRSLSFEECPDYEGYRKLLLSVLDDL 282 >3T04-A nrPDB Length = 123 Score = 127 bits (319), Expect = 2e-29, Method: Composition-based stats. Identities = 33/116 (28%), Positives = 60/116 (51%), Gaps = 7/116 (6%) Query: 7 ADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTI 66 +S ++ G ++R AE YL+ G+ +G +L+R+S + G ++S+ + + +HY I Sbjct: 10 VNSLEKHSWYHGPVSRNAAE-YLLSSGI-NGSFLVRESESSPGQRSISLRYEGRVYHYRI 67 Query: 67 ERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPF---NRPQ--GVQPKT 117 +G ++ + A+L H+HS +DGL+ L P N+P GV P Sbjct: 68 NTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNY 123 Score = 122 bits (305), Expect = 7e-28, Method: Composition-based stats. Identities = 41/103 (39%), Positives = 60/103 (58%), Gaps = 3/103 (2%) Query: 160 TTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDN-NGSYALCLLHEGKVLHYRI 218 + EK W+HG +SR +E L+ S NG FL+R ++ G ++ L +EG+V HYRI Sbjct: 10 VNSLEKHSWYHGPVSRNAAE--YLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRI 67 Query: 219 DKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQK 261 + GKL + +F+TL +LV H+S ADGL+ L P K Sbjct: 68 NTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPK 110 >6HMD-A nrPDB Length = 365 Score = 125 bits (313), Expect = 8e-29, Method: Composition-based stats. Identities = 51/352 (14%), Positives = 113/352 (32%), Gaps = 64/352 (18%) Query: 326 ELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTV 385 + P A R +++ + + D +L+ ++LG G + V Sbjct: 14 DPMPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLV----RKLGRGKYSEV 69 Query: 386 KKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDN-PYIVRMIGICEA--- 441 + + P K ++ E +++ L I+++I + Sbjct: 70 FEAINITNNERVV-------VKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVS 122 Query: 442 ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVL 501 ++ LV E + Q + D +I ++++ + Y +HRD+ NV+ Sbjct: 123 KTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVM 179 Query: 502 LV-TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY-APECI-NYYKFSSKSDVWSF 558 + Q ++ D+GL++ + Y + + +++ PE + +Y + D+WS Sbjct: 180 IDHQQKKLRLIDWGLAEFYHPAQEY-----NVRVASRYFKGPELLVDYQMYDYSLDMWSL 234 Query: 559 GVLMWEAFSYGQKPYRGMKGSEVTAMLEKG------------ERMGCPAGC--------- 597 G ++ + + G + + K + Sbjct: 235 GCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSR 294 Query: 598 ---------------PREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVV 634 E DL++ YD + R Y+Y VV Sbjct: 295 KRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME--HPYFYPVV 344 >4M4Z-A nrPDB Length = 170 Score = 124 bits (312), Expect = 1e-28, Method: Composition-based stats. Identities = 31/98 (31%), Positives = 52/98 (53%), Gaps = 5/98 (5%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGR-----KAHHYTIERE 69 + + ++RE+AE+ L+ G G +L+R+S+ G ++LSV R + HY I Sbjct: 71 WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCL 130 Query: 70 LNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPF 107 NG I+ T S L ++S+ +D + CLLK+P Sbjct: 131 DNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPC 168 Score = 111 bits (277), Expect = 1e-24, Method: Composition-based stats. Identities = 34/101 (33%), Positives = 50/101 (49%), Gaps = 6/101 (5%) Query: 165 KMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHE-----GKVLHYRI 218 W + +SRE++E+++L+ G FLIR GSY+L + ++ HYRI Sbjct: 68 SHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRI 127 Query: 219 DKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPC 259 G L I F +L LV+HYS AD + +L PC Sbjct: 128 HCLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPC 168 >2JD5-A nrPDB Length = 373 Score = 124 bits (312), Expect = 1e-28, Method: Composition-based stats. Identities = 41/233 (17%), Positives = 97/233 (41%), Gaps = 38/233 (16%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNP- 430 + ++LG G+F TV + VA+KI++ D + E ++Q++++ Sbjct: 22 ILVRKLGWGHFSTVWLAKDMVNNT--HVAMKIVR---GDKVYTEAAEDEIKLLQRVNDAD 76 Query: 431 ----------YIVRMIGICEAE-----SWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIE 473 +I++++ + ++V E+ L +++ +R + + + Sbjct: 77 NTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVL-GENLLALIKKYEHRGIPLIYVKQ 135 Query: 474 LVHQVSMGMKYLEES-NFVHRDLAARNVL---LVTQH---YAKISDFGLSKALRADENYY 526 + Q+ +G+ Y+ +H D+ NVL + + KI+D G + Y Sbjct: 136 ISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACW------YD 189 Query: 527 KAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGS 579 + T+ ++ +PE + + +D+WS L++E + G + +G Sbjct: 190 EHYTNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELIT-GDFLFEPDEGH 241 >4F9B-A nrPDB Length = 361 Score = 120 bits (301), Expect = 2e-27, Method: Composition-based stats. Identities = 49/283 (17%), Positives = 98/283 (34%), Gaps = 54/283 (19%) Query: 370 LTLEDKELGSGNFGTVKKGYYQMK-KVVKTVAVKILKNEANDPALKDELLAEANVMQQLD 428 +EDK +G G F +V Q++ + +A+K L ++ + EL Q Sbjct: 23 FKIEDK-IGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQ-- 79 Query: 429 NPYIVRM-IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 487 ++ + + + ++ M E L + + + E + + +K + + Sbjct: 80 -DNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNS---LSFQEVREYMLNLFKALKRIHQ 135 Query: 488 SNFVHRDLAARNVLLVTQHYAK---ISDFGLS-----------KALRADENYYKAQTHGK 533 VHRD+ N L + K + DFGL+ K ++++ + + Sbjct: 136 FGIVHRDVKPSNFLYNRR--LKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKC 193 Query: 534 --------------WPVKWYAPECINYYK-FSSKSDVWSFGVLMWEAFSYGQKPYRGMKG 578 + APE + ++ D+WS GV+ S G+ P+ Sbjct: 194 SICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLS-GRYPFYKASD 252 Query: 579 SEV-----------TAMLEKGERMGCPAGCPREM--YDLMNLC 608 ++ + G C +E+ DL LC Sbjct: 253 DLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLC 295 >2X7G-A nrPDB Length = 389 Score = 120 bits (300), Expect = 2e-27, Method: Composition-based stats. Identities = 43/271 (15%), Positives = 94/271 (34%), Gaps = 74/271 (27%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLD-----N 429 ++LG G+F TV + K + VA+K++K+ + L E +++ + + Sbjct: 37 RKLGWGHFSTVWLCWDMQGK--RFVAMKVVKSA---QHYTETALDEIKLLKCVRESDPSD 91 Query: 430 PY---IVRMIGICEAE-----SWMLVMEMAELGPLNKYLQQN-RHVKDKNIIELVHQVSM 480 P +V++I + +V E+ L ++ N + + + + ++ QV Sbjct: 92 PNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQ 151 Query: 481 GMKYLEES-NFVHRDLAARNVLLVTQH--------------------------------- 506 G+ YL +H D+ N+L+ Sbjct: 152 GLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPAAD 211 Query: 507 --------------YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSK 552 KI+D G + + K T ++ + E + +S+ Sbjct: 212 LLVNPLDPRNADKIRVKIADLGNACWVH------KHFTEDIQTRQYRSIEVLIGAGYSTP 265 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTA 583 +D+WS + +E + G + G + + Sbjct: 266 ADIWSTACMAFE-LATGDYLFEPHSGEDYSR 295 >4WUA-A nrPDB Length = 401 Score = 119 bits (299), Expect = 4e-27, Method: Composition-based stats. Identities = 46/273 (16%), Positives = 95/273 (34%), Gaps = 76/273 (27%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDN----- 429 ++LG G+F TV + K K VA+K++K+ + L E +++ + N Sbjct: 47 RKLGWGHFSTVWLSWDIQGK--KFVAMKVVKSA---EHYTETALDEIRLLKSVRNSDPND 101 Query: 430 PY---IVRMIGICE-----AESWMLVMEMAELGPLNKYLQQN-RHVKDKNIIELVHQVSM 480 P +V+++ + +V E+ L ++ N + + + +++ QV Sbjct: 102 PNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQ 161 Query: 481 GMKYLEES-NFVHRDLAARNVLLV------------------------------------ 503 G+ YL +H D+ N+LL Sbjct: 162 GLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPATA 221 Query: 504 -------------TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 + KI+D G + + K T ++ + E + ++ Sbjct: 222 GNFLVNPLEPKNAEKLKVKIADLGNACWVH------KHFTEDIQTRQYRSLEVLIGSGYN 275 Query: 551 SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTA 583 + +D+WS + +E + G + G E T Sbjct: 276 TPADIWSTACMAFE-LATGDYLFEPHSGEEYTR 307 >4LFI-A nrPDB Length = 374 Score = 118 bits (297), Expect = 5e-27, Method: Composition-based stats. Identities = 33/199 (16%), Positives = 73/199 (36%), Gaps = 23/199 (11%) Query: 429 NPYIVRMIGICEA---ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYL 485 + I+ + I + ++ LV E + + + D I + ++ + Y Sbjct: 132 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPK---LTDLEIRFYMFELLKALDYC 188 Query: 486 EESNFVHRDLAARNVLLVTQH-YAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 +HRD+ NV++ ++ ++ D+GL+ Y + ++ + PE + Sbjct: 189 HSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA-EFYHVNMEYNVRVASRF---FKGPELL 244 Query: 545 -NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG--------ERMGCPA 595 +Y + D+WSFG ++ + + G ++ + K + Sbjct: 245 VDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEI 304 Query: 596 GCPREMYD---LMNLCWTY 611 PRE YD + W Sbjct: 305 TLPREFYDMDQYIRKPWHR 323 >5U06-A nrPDB Length = 120 Score = 118 bits (296), Expect = 7e-27, Method: Composition-based stats. Identities = 34/99 (34%), Positives = 53/99 (53%), Gaps = 4/99 (4%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTI---ERELN 71 +F G I+REE++ + Q G+ DGL+L+R+S+ GF LS+ H +K HY I E E Sbjct: 19 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 78 Query: 72 GTYAIAGGRTHAS-PADLCHYHSQESDGLVCLLKKPFNR 109 +++ G+T + L +H L CLL+ R Sbjct: 79 LYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTR 117 Score = 108 bits (269), Expect = 9e-24, Method: Composition-based stats. Identities = 37/114 (32%), Positives = 53/114 (46%), Gaps = 6/114 (5%) Query: 151 KPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRAR-DNNGSYALCLLH 209 P ++ H WFHG+ISREES++++ +G FL+R N + L L H Sbjct: 2 SPASGTSLSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCH 61 Query: 210 EGKVLHYRI-DKDKTGKLSI---PEGKKFDTLWQLVEHYSYKADGLLRVLTVPC 259 KV HY I ++ G+L +F L QLVE + G+L L C Sbjct: 62 LQKVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNR-GILPCLLRHC 114 >5OAT-A nrPDB Length = 411 Score = 115 bits (287), Expect = 7e-26, Method: Composition-based stats. Identities = 59/317 (18%), Positives = 102/317 (32%), Gaps = 69/317 (21%) Query: 365 LDRKLLTLEDKELGS----GNFGTVKKGYYQMKKVVKT---VAVKIL---KNEANDPALK 414 + +TL D LG G G V + + A+K++ + N + Sbjct: 3 FESNPITLNDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEIL 62 Query: 415 DELLAE--------------------ANVMQQLD-NPYIVRMIGICEA------------ 441 + E AN + L +P IV + + Sbjct: 63 KAMYRETVPARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHP 122 Query: 442 ------ESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDL 495 S L+M+ + L +L + + L+ Q+ G+ ++ HRDL Sbjct: 123 EGEGRNMSLFLLMKRYDC-NLQSFLSTAP--STRTSLLLLAQLLEGVAHMTAHGIAHRDL 179 Query: 496 AARNVLLVTQH----YAKISDFGLS---KALRADENYYKAQTHGKWPVKWYAPECINYYK 548 + N+LL T ISDFG K Y + APE I Sbjct: 180 KSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKP 239 Query: 549 -------FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREM 601 +S K+D+W+ G + +E F+ P+ G + ++G+ P P + Sbjct: 240 GTFSVLNYS-KADLWAVGAIAYEIFNC-HNPFYGPSRLKNFN-YKEGDLPKLPDEVPTVI 296 Query: 602 YDLMNLCWTYDVENRPG 618 L+ + R Sbjct: 297 QALVANLLKRNPNKRLD 313 >4L68-A nrPDB Length = 340 Score = 113 bits (283), Expect = 2e-25, Method: Composition-based stats. Identities = 43/191 (22%), Positives = 74/191 (38%), Gaps = 12/191 (6%) Query: 383 GTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICE-A 441 GT K +AVK L E E N + +L + + ++G C Sbjct: 54 GTTYKALL---PDGSALAVKHLSTCKLGER---EFRYEMNQLWELRHSNLAPLLGFCVVE 107 Query: 442 ESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEE---SNFVHRDLAA 497 E LV + G L+ L NR + + + G+ +L +H+++ + Sbjct: 108 EEKFLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICS 167 Query: 498 RNVLLVTQHYAKISDFGLSK-ALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVW 556 +L+ A+I D GL++ + +D N T + APE S K DV+ Sbjct: 168 SVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEYSTTMLASLKGDVY 227 Query: 557 SFGVLMWEAFS 567 GV++ E + Sbjct: 228 GLGVVLLELAT 238 >2AUG-A nrPDB Length = 126 Score = 113 bits (283), Expect = 2e-25, Method: Composition-based stats. Identities = 32/114 (28%), Positives = 57/114 (50%), Gaps = 9/114 (7%) Query: 5 GMADSANHL-----PFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGR 59 G+ +H+ P+F I+R+EA+ ++Q G+ DG++L+R S++ F LS++HG+ Sbjct: 13 GLVPRGSHMIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQ 72 Query: 60 KAHHYTI---ERELNGTYAIAGGRTHAS-PADLCHYHSQESDGLVCLLKKPFNR 109 K H+ I E + + + G T + L ++ L C LK R Sbjct: 73 KIKHFQIIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCAR 126 Score = 105 bits (261), Expect = 8e-23, Method: Composition-based stats. Identities = 32/108 (29%), Positives = 54/108 (50%), Gaps = 5/108 (4%) Query: 159 ATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRAR-DNNGSYALCLLHEGKVLHYR 217 + H PWFH KISR+E++++++ +G FL+R N ++ L + H K+ H++ Sbjct: 19 SHMIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQ 78 Query: 218 I---DKDKTGKLSIPEGK-KFDTLWQLVEHYSYKADGLLRVLTVPCQK 261 I + D ++ +G +F L QLVE Y L L C + Sbjct: 79 IIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCAR 126 >5X1R-A nrPDB Length = 302 Score = 113 bits (282), Expect = 3e-25, Method: Composition-based stats. Identities = 44/281 (15%), Positives = 100/281 (35%), Gaps = 39/281 (13%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVK-------ILKNEANDPALKDE----------- 416 + +G G FG V + Y ++ +T+A+K +N+ L+ E Sbjct: 27 EAIGEGGFGIVYRAYDH--QLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQAGLN 84 Query: 417 -LLAEANVMQQLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKY-LQQNRHVKDKNIIE 473 + EA ++ + +P ++ ++ E + + + L QQ + + I Sbjct: 85 SFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQPEKIDEAWIRR 144 Query: 474 LVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGK 533 L+ + + + + ++HRD++ N+ + + DFG ++ + +T Sbjct: 145 LLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARK---EIGNLSDETEIV 201 Query: 534 WPVKWYAPECINYYKFSSK---SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGER 590 + E + +D+++ G ++ G P V +E + Sbjct: 202 LKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLI-VGSPP-----PVSVVRSIEDSYQ 255 Query: 591 M---GCPAGCPREMYDLMNLCWTYDVENRP-GFAAVELRLR 627 PAG E+ ++ E+RP + L Sbjct: 256 PLTERRPAGYSPELLRTVDRALALKPEDRPQTIDEMAELLE 296 >1KA6-A nrPDB Length = 128 Score = 112 bits (280), Expect = 5e-25, Method: Composition-based stats. Identities = 34/123 (27%), Positives = 58/123 (47%), Gaps = 11/123 (8%) Query: 169 FHGKISREESEQIVLIGSKTNGKFLIRARDN-NGSYALCLLHEGKVLHYRIDKDKTGKLS 227 +HGKISRE E+++L + +G +L+R ++ G Y LC+L+ G + YR+ + +TG S Sbjct: 7 YHGKISRETGEKLLL-ATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWS 65 Query: 228 IPEG-----KKFDTLWQLVEHYSYKADGLLRVLTVPCQKI----GTQGNVNFGGRPQLPG 278 + F + L+ + G++ L P +K TQG P + Sbjct: 66 AETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEKKSSARSTQGTTGIREDPDVCL 125 Query: 279 SHP 281 P Sbjct: 126 KAP 128 Score = 68.5 bits (166), Expect = 8e-12, Method: Composition-based stats. Identities = 28/108 (25%), Positives = 47/108 (43%), Gaps = 6/108 (5%) Query: 16 FFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYA 75 + G I+RE E L+ G+ DG YLLR S + G + L V + + Y + + G+++ Sbjct: 7 YHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWS 65 Query: 76 --IAGG---RTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTG 118 A G R +L + G+V L+ P + + G Sbjct: 66 AETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEKKSSARSTQG 113 >4I94-A nrPDB Length = 300 Score = 112 bits (280), Expect = 5e-25, Method: Composition-based stats. Identities = 51/242 (21%), Positives = 101/242 (41%), Gaps = 20/242 (8%) Query: 384 TVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC-EAE 442 V KG + + + +AVK ++ + L EA + QL N + ++G C E E Sbjct: 44 VVYKGKLENQ---RRIAVKRFNRKSW--PDSRQFLEEAKAVGQLRNHRMANLLGCCYEDE 98 Query: 443 SWMLVMEMAELGPLNKYLQ--QNRHVKDKNIIELVHQVSMGMKYLEESN-FVHRDLAARN 499 +L+ E L K+L +++ +K + + ++ ++Y ++ DL A Sbjct: 99 ERLLIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYR 158 Query: 500 VLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFG 559 VL ++S FGL K R ++Y + + PE + + + +S ++SFG Sbjct: 159 VLFDDDANPRLSCFGLMKNSRDGKSYSTN-------LAFTPPEYLRTGRVTPESVIYSFG 211 Query: 560 VLMWEAFSYGQKPYRG----MKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVEN 615 L+ + S P ++ + +++ G + E+ L + C Y+ Sbjct: 212 TLLLDLLSGKHIPPSHALDLIRDRNIQMLMDSGLEGQFSSDDGTELIRLASRCLQYEPRE 271 Query: 616 RP 617 RP Sbjct: 272 RP 273 >6EQI-C nrPDB Length = 433 Score = 110 bits (276), Expect = 1e-24, Method: Composition-based stats. Identities = 53/313 (16%), Positives = 100/313 (31%), Gaps = 71/313 (22%) Query: 374 DKELGSGNFGTVKKGYYQM---KKVVKTVAVKIL---KNEANDPALKDELLAE------- 420 + + G V + K+ +AVK++ E+N A+ + E Sbjct: 20 GEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRETVPAMSY 79 Query: 421 --------ANVMQQLD-----NPYIVRMIGICEAE------------------------- 442 + +P IVRM + Sbjct: 80 FFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRINPEGSG 139 Query: 443 ---SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARN 499 S LVM+ + L +YL+ ++ I L+ Q+ + ++ N HRDL + N Sbjct: 140 RNMSLFLVMKRYDC-TLKEYLRDKTP-NMRSSILLLSQLLEAVAHMNIHNISHRDLKSDN 197 Query: 500 VLLVTQH-----YAKISDFGLSKALRADE---NYYKAQTHGKWPVKWYAPECINYYKFS- 550 +L+ I+DFG + + Y APE N + Sbjct: 198 ILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEIANAKPGTF 257 Query: 551 -----SKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLM 605 KSD+W+ G + +E F+ P+ ++ ++ + P P + +L+ Sbjct: 258 SWLNYKKSDLWAVGAIAYEIFNI-DNPFYDKTMKLLSKSYKEEDLPELPDTIPFIIRNLV 316 Query: 606 NLCWTYDVENRPG 618 + + R Sbjct: 317 SNMLSRSTNKRLD 329 >6CMQ-A nrPDB Length = 427 Score = 110 bits (275), Expect = 2e-24, Method: Composition-based stats. Identities = 42/157 (26%), Positives = 69/157 (43%), Gaps = 19/157 (12%) Query: 5 GMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGR----- 59 G D + +F G+++ +EAE L + G G +L+R+S+++ G F LSV G Sbjct: 1 GSGDPTS-ERWFHGHLSGKEAEKLLTEKG-KHGSFLVRESQSHPGDFVLSVRTGDDKGES 58 Query: 60 -----KAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQES----DGLVCLLKKPFN-- 108 K H I + Y + GG S DL ++ + G V LK+P N Sbjct: 59 NDGKSKVTHVMIRCQ-ELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTT 117 Query: 109 RPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQ 145 R + ++ E K + VKQ + + + L+Q Sbjct: 118 RINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQ 154 Score = 90.5 bits (223), Expect = 2e-18, Method: Composition-based stats. Identities = 33/136 (24%), Positives = 53/136 (38%), Gaps = 26/136 (19%) Query: 149 SQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRAR-DNNGSYALCL 207 S P E+ WFHG +S +E+E+++ K +G FL+R + G + L + Sbjct: 2 SGDPTSER-----------WFHGHLSGKEAEKLLTEKGK-HGSFLVRESQSHPGDFVLSV 49 Query: 208 LHEG----------KVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTV 257 KV H I + + K + G++FD+L LVEHY ++ L Sbjct: 50 RTGDDKGESNDGKSKVTHVMI-RCQELKYDVGGGERFDSLTDLVEHYKKNP--MVETLGT 106 Query: 258 PCQKIGTQGNVNFGGR 273 Q Sbjct: 107 VLQLKQPLNTTRINAA 122 >2EKX-A nrPDB Length = 110 Score = 108 bits (269), Expect = 1e-23, Method: Composition-based stats. Identities = 29/104 (27%), Positives = 50/104 (48%), Gaps = 7/104 (6%) Query: 163 HEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHE------GKVLHY 216 + WF G ISR +SEQ++ K G F++R G Y + L + G V HY Sbjct: 8 LDDYDWFAGNISRSQSEQLLRQKGKE-GAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHY 66 Query: 217 RIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQ 260 + + KL + E FD++ +L+ ++ + + G++ L P Sbjct: 67 HVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVS 110 Score = 74.7 bits (182), Expect = 1e-13, Method: Composition-based stats. Identities = 30/113 (26%), Positives = 50/113 (44%), Gaps = 12/113 (10%) Query: 2 ASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSV------ 55 SSG+ D +F GNI+R ++E L Q G +G +++R S + +G + +S+ Sbjct: 4 GSSGLDD----YDWFAGNISRSQSEQLLRQKG-KEGAFMVRNS-SQVGMYTVSLFSKAVN 57 Query: 56 AHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFN 108 HY + +A S L HYH S G++ L+ P + Sbjct: 58 DKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVS 110 >6J6I-B nrPDB Length = 351 Score = 107 bits (266), Expect = 2e-23, Method: Composition-based stats. Identities = 48/283 (16%), Positives = 105/283 (37%), Gaps = 35/283 (12%) Query: 385 VKKGYYQMKKVVKTVAVKILKNE--ANDPALKDELLAEANV-MQQLDNPYIVRMIGICEA 441 V +Y+ + ++ +K + E+ + + + ++ ++++G C Sbjct: 70 VYYKWYRGEIEDRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLE 129 Query: 442 ESW-MLVMEMAELGPLNK---YLQ--QNRHVKDKNIIELVHQVSMGMKYLEE---SNFVH 492 + +LV E AE G +N+ + + + +++ +++ + YL +H Sbjct: 130 FPFPVLVFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIH 189 Query: 493 RDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSK 552 RD+ +V L AK+SD S +L ++ +A+ + P + Sbjct: 190 RDVKPMHVFLDKNWTAKLSDLSFSISLPEGKSRIEAE-WVLGTFGYIDPLYHKTCFVTEY 248 Query: 553 SDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYD--LMN---- 606 +DV+SFG+ + + G+ + ++ +L + C G E+ D LM Sbjct: 249 TDVYSFGICLLVIIT-GKPAIMTISDGDLQGILSLVREL-CENGKLDEVIDPRLMKDITS 306 Query: 607 --------------LCWTYDVENRPGFAAVELRLRNYYYDVVN 635 C E+RP V L+ + N Sbjct: 307 GQRLQVEACVVLALRCCKERDEDRPKMIQVAKELKQIEASLKN 349 >1GRI-A nrPDB Length = 217 Score = 107 bits (266), Expect = 2e-23, Method: Composition-based stats. Identities = 29/83 (34%), Positives = 44/83 (53%), Gaps = 2/83 (2%) Query: 14 PFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGT 73 P+FFG I R +AE+ L + DG +L+R+S + G F+LSV G H+ + R+ G Sbjct: 59 PWFFGKIPRAKAEEMLSKQ-RHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGK 117 Query: 74 YAIAGGRTHASPADLCHYHSQES 96 Y + + S +L YH S Sbjct: 118 YFLWVVK-FNSLNELVDYHRSTS 139 Score = 95.1 bits (235), Expect = 9e-20, Method: Composition-based stats. Identities = 32/128 (25%), Positives = 58/128 (45%), Gaps = 9/128 (7%) Query: 155 EKLIATTAHEK--MPWFHGKISREESEQIVLIGSKTNGKFLIRARDN-NGSYALCLLHEG 211 + I E PWF GKI R ++E++ L + +G FLIR ++ G ++L + Sbjct: 45 DGFIPKNYIEMKPHPWFFGKIPRAKAEEM-LSKQRHDGAFLIRESESAPGDFSLSVKFGN 103 Query: 212 KVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKA----DGLLRVLTVPCQKIGTQGN 267 V H+++ +D GK + KF++L +LV+++ + + + T Sbjct: 104 DVQHFKVLRDGAGKYFL-WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQ 162 Query: 268 VNFGGRPQ 275 F PQ Sbjct: 163 ALFDFDPQ 170 >5M07-A nrPDB Length = 276 Score = 106 bits (265), Expect = 3e-23, Method: Composition-based stats. Identities = 35/206 (16%), Positives = 76/206 (36%), Gaps = 28/206 (13%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNE-ANDPALKDELLAEANVMQQLDNPYIV 433 + LG+ G V + + A+K+L A D + E V +L +P+I+ Sbjct: 36 RMLGASAMGEVYLVQHPGFPGWQ--ALKVLSPAMAADDEFRRRFQRETEVAARLFHPHIL 93 Query: 434 RMIGICEAES-WMLVMEMAELGPLNKYLQQNRH--VKDKNIIELVHQVSMGMKYLEESNF 490 + E + + M+ + +++ + ++ +V V+ + Y + Sbjct: 94 EVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYAHQRGL 153 Query: 491 VHRDLAARNVLLVT----QHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINY 546 +HRD+ NV+L + ++DFG++ + APE Sbjct: 154 LHRDVNPANVVLTSQSAGDQRILLADFGIASQ-----------------PSYPAPELSAG 196 Query: 547 YKFSSKSDVWSFGVLMWEAFSYGQKP 572 ++D ++ + F+ G P Sbjct: 197 ADVDGRADQYALALTAIHLFA-GAPP 221 >1NRV-A nrPDB Length = 105 Score = 106 bits (265), Expect = 3e-23, Method: Composition-based stats. Identities = 29/99 (29%), Positives = 49/99 (49%), Gaps = 4/99 (4%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTI---ERELN 71 +F G I+REE+ + Q G+ DGL+LLR S++ F L++ H +K ++ I E + Sbjct: 7 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 66 Query: 72 GTYAIAGGRT-HASPADLCHYHSQESDGLVCLLKKPFNR 109 +++ G T + L ++ L C LK R Sbjct: 67 TFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIR 105 Score = 102 bits (254), Expect = 6e-22, Method: Composition-based stats. Identities = 35/102 (34%), Positives = 50/102 (49%), Gaps = 5/102 (4%) Query: 163 HEKMPWFHGKISREESEQIVLIGSKTNGKFLIRAR-DNNGSYALCLLHEGKVLHYRI--- 218 H WFHG+ISREES +I+ +G FL+R N ++ L L H K+ +++I Sbjct: 2 HRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPC 61 Query: 219 DKDKTGKLSIPEG-KKFDTLWQLVEHYSYKADGLLRVLTVPC 259 + D S+ +G KF L QLV+ Y L L C Sbjct: 62 EDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHC 103 >5UV4-A nrPDB Length = 311 Score = 105 bits (263), Expect = 4e-23, Method: Composition-based stats. Identities = 40/205 (19%), Positives = 81/205 (39%), Gaps = 19/205 (9%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 + +G GT K + VK LK K E E + + +P +V Sbjct: 31 EIIGRSCHGTSYKATLDN---GYMLTVKWLKEGFAKS--KKEFSREIKKLGSVRHPNLVP 85 Query: 435 MIGIC---EAESWMLVMEMAELGPLNKYL-----QQNRHVKDKNIIELVHQVSMGMKYLE 486 + G + +++ + A+ L+ YL + + + + ++ + YL Sbjct: 86 LRGYYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLH 145 Query: 487 ESNFV-HRDLAARNVLL-VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 + H ++ + NVL+ + A ++D+ L + + Q + + PE Sbjct: 146 NERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIG--MAEQVLNAGALGYSPPEFS 203 Query: 545 NYYK--FSSKSDVWSFGVLMWEAFS 567 + K S KSDV++FGV++ E + Sbjct: 204 STSKPCPSLKSDVYAFGVILLELLT 228 >2PZI-A nrPDB Length = 681 Score = 104 bits (260), Expect = 1e-22, Method: Composition-based stats. Identities = 33/195 (16%), Positives = 71/195 (36%), Gaps = 19/195 (9%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 + G G + + + V +K L + D + +AE + ++ +P IV++ Sbjct: 88 IAHGGLGWIYLALDRNVN-GRPVVLKGL-VHSGDAEAQAMAMAERQFLAEVVHPSIVQIF 145 Query: 437 GICEAESW------MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 E +VME L + + + + I + ++ + YL Sbjct: 146 NFVEHTDRHGDPVGYIVMEYVGGQSLKR--SKGQKLPVAEAIAYLLEILPALSYLHSIGL 203 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 V+ DL N++L + K+ D G + + Y + APE + + Sbjct: 204 VYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY-------GTPGFQAPEIVRTGP-T 254 Query: 551 SKSDVWSFGVLMWEA 565 +D+++ G + Sbjct: 255 VATDIYTVGRTLAAL 269 >4Y12-A nrPDB Length = 375 Score = 103 bits (258), Expect = 2e-22, Method: Composition-based stats. Identities = 33/195 (16%), Positives = 71/195 (36%), Gaps = 19/195 (9%) Query: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMI 436 + G G + + + V +K L + D + +AE + ++ +P IV++ Sbjct: 127 IAHGGLGWIYLALDRNVN-GRPVVLKGL-VHSGDAEAQAMAMAERQFLAEVVHPSIVQIF 184 Query: 437 GICEAESW------MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 E +VME L + + + + I + ++ + YL Sbjct: 185 NFVEHTDRHGDPVGYIVMEYVGGQSLKR--SKGQKLPVAEAIAYLLEILPALSYLHSIGL 242 Query: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFS 550 V+ DL N++L + K+ D G + + Y + APE + + Sbjct: 243 VYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY-------GTPGFQAPEIVRTGP-T 293 Query: 551 SKSDVWSFGVLMWEA 565 +D+++ G + Sbjct: 294 VATDIYTVGRTLAAL 308 >2EOB-A nrPDB Length = 124 Score = 102 bits (255), Expect = 5e-22, Method: Composition-based stats. Identities = 33/99 (33%), Positives = 50/99 (50%), Gaps = 2/99 (2%) Query: 161 TAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDK 220 HE PW++ ++SR E+E + L+ +G FLIR R+ SYA+ GKV H RI++ Sbjct: 14 NPHESKPWYYDRLSRGEAEDM-LMRIPRDGAFLIRKREGTDSYAITFRARGKVKHCRINR 72 Query: 221 DKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPC 259 D + F++L +LV +Y A L P Sbjct: 73 DGR-HFVLGTSAYFESLVELVSYYEKHALYRKMRLRYPV 110 Score = 70.8 bits (172), Expect = 2e-12, Method: Composition-based stats. Identities = 24/113 (21%), Positives = 48/113 (42%), Gaps = 4/113 (3%) Query: 7 ADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTI 66 + P+++ ++R EAED L+ DG +L+R+ +A++ K H I Sbjct: 13 PNPHESKPWYYDRLSRGEAEDMLM-RIPRDGAFLIRKREGT-DSYAITFRARGKVKHCRI 70 Query: 67 ERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGP 119 R + + S +L Y+ + + L+ P P+ ++ +GP Sbjct: 71 NR-DGRHFVLGTSAYFESLVELVSYYEKHALYRKMRLRYPVT-PELLERYSGP 121 >5M6U-B nrPDB Length = 724 Score = 102 bits (253), Expect = 6e-22, Method: Composition-based stats. Identities = 29/102 (28%), Positives = 47/102 (46%), Gaps = 7/102 (6%) Query: 163 HEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDK 222 H++ W G +R ++E ++ K +G FL+R G YA ++ +G+V H I+K Sbjct: 619 HDEKTWNVGSSNRNKAENLL--RGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTA 676 Query: 223 TGKLSIPEGKKFDTLWQLVEHYSY-----KADGLLRVLTVPC 259 TG + +L +LV HY + D L L P Sbjct: 677 TGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPV 718 Score = 67.0 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 34/136 (25%), Positives = 61/136 (44%), Gaps = 12/136 (8%) Query: 1 MASSGMAD--SANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQ-SRNYLGGFALSVAH 57 +A++GM + S +++G+I+REE + L +DG +L+R S G + L++ Sbjct: 317 VANNGMNNNMSLQDAEWYWGDISREEVNEKL--RDTADGTFLVRDASTKMHGDYTLTLRK 374 Query: 58 GRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDG-----LVCLLKKPFNRPQG 112 G I +G Y + T +S +L +++ ES L L P ++ Q Sbjct: 375 GGNNKLIKI-FHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQ 433 Query: 113 VQ-PKTGPFEDLKENL 127 Q K E + + L Sbjct: 434 DQVVKEDNIEAVGKKL 449 Score = 65.0 bits (157), Expect = 1e-10, Method: Composition-based stats. Identities = 25/97 (25%), Positives = 42/97 (43%), Gaps = 8/97 (8%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74 + G+ R +AE+ L G DG +L+R+S + G +A SV + H I + G Sbjct: 624 WNVGSSNRNKAENLL--RGKRDGTFLVRES-SKQGCYACSVVVDGEVKHCVINKTATGYG 680 Query: 75 AIAGGRTHASPADLCHYHS-----QESDGLVCLLKKP 106 ++S +L ++ Q +D L L P Sbjct: 681 FAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYP 717 Score = 63.9 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 27/109 (24%), Positives = 44/109 (40%), Gaps = 10/109 (9%) Query: 162 AHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDN--NGSYALCLLHEGKVLHYRID 219 + + W+ G ISREE + + +G FL+R +G Y L L G +I Sbjct: 327 SLQDAEWYWGDISREEVNE--KLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKI- 383 Query: 220 KDKTGKLSIPEGKKFDTLWQLVEHYSYKADG-----LLRVLTVPCQKIG 263 + GK + F ++ +L+ HY ++ L L P K Sbjct: 384 FHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQ 432 >2PLE-A nrPDB Length = 105 Score = 101 bits (252), Expect = 8e-22, Method: Composition-based stats. Identities = 28/103 (27%), Positives = 50/103 (48%), Gaps = 3/103 (2%) Query: 163 HEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDK 222 HE W+H ++R ++E + L+ +G FL+R R+ SYA+ EGK+ H R+ + Sbjct: 6 HESKEWYHASLTRAQAEHM-LMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQ-- 62 Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQ 265 G+ + +FD+L L+ +Y L P + + Sbjct: 63 EGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEENSS 105 Score = 67.3 bits (163), Expect = 2e-11, Method: Composition-based stats. Identities = 25/99 (25%), Positives = 43/99 (43%), Gaps = 4/99 (4%) Query: 11 NHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIEREL 70 ++ ++TR +AE L+ DG +L+R+ RN +A+S K H +++E Sbjct: 7 ESKEWYHASLTRAQAEHMLM-RVPRDGAFLVRK-RNEPNSYAISFRAEGKIKHCRVQQE- 63 Query: 71 NGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNR 109 G + G S DL Y+ + L+ P N Sbjct: 64 -GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINE 101 >1M27-A nrPDB Length = 104 Score = 100 bits (248), Expect = 3e-21, Method: Composition-based stats. Identities = 29/99 (29%), Positives = 52/99 (52%), Gaps = 7/99 (7%) Query: 169 FHGKISREESEQIVLIGSKTNGKFLIRARDN-NGSYALCLLHEGKVLHYRIDKDKTGKLS 227 +HGKISRE E+++L + +G +L+R ++ G Y LC+L+ G + YR+ + +TG S Sbjct: 7 YHGKISRETGEKLLL-ATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWS 65 Query: 228 IPEG-----KKFDTLWQLVEHYSYKADGLLRVLTVPCQK 261 + F + L+ + G++ L P +K Sbjct: 66 AETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEK 104 Score = 68.1 bits (165), Expect = 1e-11, Method: Composition-based stats. Identities = 27/99 (27%), Positives = 45/99 (45%), Gaps = 6/99 (6%) Query: 16 FFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYA 75 + G I+RE E L+ G+ DG YLLR S + G + L V + + Y + + G+++ Sbjct: 7 YHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWS 65 Query: 76 --IAGG---RTHASPADLCHYHSQESDGLVCLLKKPFNR 109 A G R +L + G+V L+ P + Sbjct: 66 AETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEK 104 >2HDV-A nrPDB Length = 111 Score = 99.3 bits (246), Expect = 4e-21, Method: Composition-based stats. Identities = 31/114 (27%), Positives = 54/114 (47%), Gaps = 11/114 (9%) Query: 163 HEKMPWFHGKISREESEQIVLIGS-KTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDK 220 PWFHG +SR ++ Q+VL G ++G FL+R + G L +GK H R+ Sbjct: 6 LSGYPWFHGMLSRLKAAQLVLEGGTGSHGVFLVRQSETRRGECVLTFNFQGKAKHLRLSL 65 Query: 221 DKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRP 274 + G+ + + F +++ ++EH+ RV +P + G+ V P Sbjct: 66 NAAGQCRV-QHLHFQSIFDMLEHF--------RVHPIPLESGGSSDVVLVSYVP 110 Score = 62.3 bits (150), Expect = 7e-10, Method: Composition-based stats. Identities = 22/93 (23%), Positives = 38/93 (40%), Gaps = 2/93 (2%) Query: 5 GMADSANHLPFFFGNITREEAEDYLVQGG-MSDGLYLLRQSRNYLGGFALSVAHGRKAHH 63 G + P+F G ++R +A +++GG S G++L+RQS G L+ KA H Sbjct: 1 GSDQPLSGYPWFHGMLSRLKAAQLVLEGGTGSHGVFLVRQSETRRGECVLTFNFQGKAKH 60 Query: 64 YTIERELNGTYAIAGGRTHASPADLCHYHSQES 96 + G + S D+ + Sbjct: 61 LRLSLNAAGQCRV-QHLHFQSIFDMLEHFRVHP 92 >2CS0-A nrPDB Length = 119 Score = 95.1 bits (235), Expect = 8e-20, Method: Composition-based stats. Identities = 33/112 (29%), Positives = 52/112 (46%), Gaps = 5/112 (4%) Query: 161 TAHEKMP-WFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRID 219 A + +P WFHG ISRE++E ++ S+ G FLIR ++ Y L + H+ + Sbjct: 10 LAQDGVPEWFHGAISREDAENLL--ESQPLGSFLIRVSHSHVGYTLSYKAQSSCCHFMVK 67 Query: 220 KDKTGKLSIP-EGKKFDTLWQLVEHYSYKADGLLR-VLTVPCQKIGTQGNVN 269 G IP E +L LV + K R +LT PC++ + + Sbjct: 68 LLDDGTFMIPGEKVAHTSLDALVTFHQQKPIEPRRELLTQPCRQKDSGPSSG 119 Score = 69.3 bits (168), Expect = 5e-12, Method: Composition-based stats. Identities = 25/84 (29%), Positives = 43/84 (51%), Gaps = 4/84 (4%) Query: 14 PFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGT 73 +F G I+RE+AE+ L G +L+R S +++G + LS H+ ++ +GT Sbjct: 17 EWFHGAISREDAENLLESQ--PLGSFLIRVSHSHVG-YTLSYKAQSSCCHFMVKLLDDGT 73 Query: 74 YAIAGGR-THASPADLCHYHSQES 96 + I G + H S L +H Q+ Sbjct: 74 FMIPGEKVAHTSLDALVTFHQQKP 97 >2EYZ-A nrPDB Length = 304 Score = 94.3 bits (233), Expect = 1e-19, Method: Composition-based stats. Identities = 35/158 (22%), Positives = 56/158 (35%), Gaps = 27/158 (17%) Query: 4 SGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHH 63 +G DS +++G ++R+EA L G G++L+R S G + LSV+ + H Sbjct: 2 AGNFDSEERSSWYWGRLSRQEAVALL--QGQRHGVFLVRDSSTSPGDYVLSVSENSRVSH 59 Query: 64 YTIERELNG-----------------TYAIAGGRTHASPADLCHYHSQESDGLVCLLKKP 106 Y I I + PA L Y D L +P Sbjct: 60 YIINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTT--LIEP 117 Query: 107 FNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALE 144 +R + E+ EYV+ ++ G E Sbjct: 118 VSRSRQGSGVILRQEE------AEYVRALFDFNGNDEE 149 Score = 72.0 bits (175), Expect = 7e-13, Method: Composition-based stats. Identities = 45/222 (20%), Positives = 69/222 (31%), Gaps = 52/222 (23%) Query: 161 TAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDN-NGSYALCLLHEGKVLHYRID 219 + E+ W+ G++SR+E+ + L+ + +G FL+R G Y L + +V HY I+ Sbjct: 6 DSEERSSWYWGRLSRQEA--VALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIIN 63 Query: 220 KDKTGKLSIP----------------EGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKI- 262 P ++FD+L L+E Y L P + Sbjct: 64 SSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLD-TTTLIEPVSRSR 122 Query: 263 -------GTQGNVNFGGRPQLPGSHPATWSA-GGIISRI----------------KSYSF 298 + G+ G I RI K Sbjct: 123 QGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMI 182 Query: 299 PKPGHRKSSPAQ-------GNRQESTVSFNPYEPELAPWAAD 333 P P K PA G QE + PE P+A Sbjct: 183 PVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQP 224 >1RPY-A nrPDB Length = 114 Score = 93.5 bits (231), Expect = 2e-19, Method: Composition-based stats. Identities = 26/112 (23%), Positives = 48/112 (42%), Gaps = 11/112 (9%) Query: 160 TTAHEKMPWFHGKISREESEQIVLIGSKT-NGKFLIRARDN-NGSYALCLLHEGKVLHYR 217 PWFHG +SR ++ Q+VL G +G F+IR + G L +GK H R Sbjct: 5 ELELSDYPWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTFNFQGKAKHLR 64 Query: 218 IDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVN 269 + + G+ + + F +++ ++ H+ +P + G+ Sbjct: 65 LSLNGHGQCHV-QHLWFQSVFDMLRHF--------HTHPIPLESGGSADITL 107 Score = 62.7 bits (151), Expect = 4e-10, Method: Composition-based stats. Identities = 22/82 (26%), Positives = 38/82 (46%), Gaps = 1/82 (1%) Query: 14 PFFFGNITREEAEDYLVQGG-MSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNG 72 P+F G ++R +A ++ GG S GL+++RQS G L+ KA H + +G Sbjct: 12 PWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTFNFQGKAKHLRLSLNGHG 71 Query: 73 TYAIAGGRTHASPADLCHYHSQ 94 + + L H+H+ Sbjct: 72 QCHVQHLWFQSVFDMLRHFHTH 93 >4JRN-A nrPDB Length = 372 Score = 87.8 bits (216), Expect = 1e-17, Method: Composition-based stats. Identities = 40/282 (14%), Positives = 83/282 (29%), Gaps = 60/282 (21%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKD-ELLAEANVMQQLD------ 428 LGSG F TV + + + +AVK+ +E +L E++ + Sbjct: 75 PLGSGGFATVYEATDV--ETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAK 132 Query: 429 -----------------------NPYIVRMIGICEAESWMLVMEMAELGPLNKYL----- 460 ++ + ++L+M ++K + Sbjct: 133 DAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMR--AEADMSKVISWVFG 190 Query: 461 ---QQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSK 517 + L Q + ++ VH D+ N LL+ + DFG + Sbjct: 191 DASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYR 250 Query: 518 ALRADENYYKAQTHGKWPVKWYAPEC---INYYKFSSKSDVWSFGVLMWEAFSYGQKPYR 574 + + PE ++ +D W G+ ++ + ++P Sbjct: 251 INNSVGR-------AIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCK-ERPTP 302 Query: 575 GMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENR 616 + CP+ P + DL+ D + R Sbjct: 303 ADGIWDYLHFA------DCPS-TPELVQDLIRSLLNRDPQKR 337 >5CLR-A nrPDB Length = 451 Score = 87.4 bits (215), Expect = 2e-17, Method: Composition-based stats. Identities = 49/239 (20%), Positives = 95/239 (39%), Gaps = 31/239 (12%) Query: 362 EVYLDRKLLTLEDKELGSG-NFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 420 E L ++ E+K G G ++ K Y KT +K +K +A E E Sbjct: 71 EASLKPIIVPTENKISGGGKSYCEQFKVYALDD--GKTYFLKSVKIDAESLT---EFTNE 125 Query: 421 ANVMQQLDNPYIVRMIGIC---EAESWMLVMEMAELGPLNKY---LQQNRHVK-DKNIIE 473 + + +L R++G + + ++ + L++Y L N ++K ++ Sbjct: 126 KDTLSKLG-----RLVGTFFNEQTQVHYILTTFIKGIDLSRYKNALPLNVNLKHFWEVLG 180 Query: 474 LVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGK 533 ++ V +K E +HRDL N++L + DFG S + + + Sbjct: 181 IMISVCHQVKQFHELGLIHRDLKPGNIMLDADMQCHLVDFGSS------SSDKEPKPASW 234 Query: 534 WPVKWYAPECINYYK---FSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGE 589 + APE FS SD+++ + E F+ P+R +K ++V ++ Sbjct: 235 GTASYLAPELNAQEDFIAFSQVSDLFALAYSLDELFN----PFRQVKFAKVDIGIKNKH 289 >6EAS-A nrPDB Length = 308 Score = 86.6 bits (213), Expect = 3e-17, Method: Composition-based stats. Identities = 40/243 (16%), Positives = 87/243 (35%), Gaps = 39/243 (16%) Query: 407 EANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWM---LVMEMAELGPLNKYLQ-- 461 + + + + + ++ + + ++G CE E +V E A G L ++L Sbjct: 78 KDWSKENESQYRKKITNLSKVSHKNFMNLLGYCEEEHPFTRVMVFEYAPNGTLFEHLHVR 137 Query: 462 QNRHVKDKNIIELVHQVSMGMKYLEESNF--VHRDLAARNVLLVTQHYAKISDFGLSKAL 519 + + + + ++ ++++ + R+ + V L AK+SD Sbjct: 138 EAEKLDWMARLRISMGIAYCLEHMHQLQTPAALRNFDSTTVYLTDDFAAKVSDL----EF 193 Query: 520 RADENYYKAQTHGKWPVKWYAP--ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMK 577 D + + T+ + +P E I +G+++ E + G+ P Sbjct: 194 WNDAKGHNSTTNNELAF---SPDMEDIVRK----------YGMVLLEILT-GRVPSSEDD 239 Query: 578 GSE---VTAMLEKGERMG---------CPAGCPREMYDLMNLCWTYDVENRPGFAAVELR 625 G V+ E G R+ P R + +++ C D + RP V R Sbjct: 240 GPLENWVSRYFEGGMRLEELIDPSIGFFPEDTARALCEVVRSCIDRDPKKRPQMKEVAAR 299 Query: 626 LRN 628 +R Sbjct: 300 MRE 302 >1MIL-A nrPDB Length = 104 Score = 83.1 bits (204), Expect = 3e-16, Method: Composition-based stats. Identities = 28/109 (25%), Positives = 49/109 (44%), Gaps = 12/109 (11%) Query: 160 TTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRAR-DNNGSYALCLLHEGKVLHYRI 218 + PWFHGK+SR E+E ++ + NG FL+R G Y L L G+ H + Sbjct: 1 GSQLRGEPWFHGKLSRREAEALL----QLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLL 56 Query: 219 DKDKTGKLSIPEGKKFDTLWQLVEHYSYK-----ADGLLRVLTVPCQKI 262 D G + + +F+++ L+ ++ + G L P ++ Sbjct: 57 -VDPEGVVRTKDH-RFESVSHLISYHMDNHLPIISAGSELCLQQPVERK 103 Score = 61.2 bits (147), Expect = 2e-09, Method: Composition-based stats. Identities = 19/80 (23%), Positives = 31/80 (38%), Gaps = 6/80 (7%) Query: 13 LPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNG 72 P+F G ++R EAE L +G +L+R+S G + L+ + H + Sbjct: 7 EPWFHGKLSRREAEALL----QLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLL--VDPE 60 Query: 73 TYAIAGGRTHASPADLCHYH 92 S + L YH Sbjct: 61 GVVRTKDHRFESVSHLISYH 80 >5UU1-A nrPDB Length = 324 Score = 81.6 bits (200), Expect = 9e-16, Method: Composition-based stats. Identities = 54/289 (18%), Positives = 106/289 (36%), Gaps = 33/289 (11%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKD-ELLA----------- 419 + K++GSG FG + + K V ++ + N P + + Sbjct: 19 VLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKW 78 Query: 420 -EANVMQQLDNP--YIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVH 476 E + L P Y + +VME L K QN K +++L Sbjct: 79 IERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERL-GIDLQKISGQNGTFKKSTVLQLGI 137 Query: 477 QVSMGMKYLEESNFVHRDLAARNVLL--VTQHYAKISDFGLSKALRADENYYKAQTHGK- 533 ++ ++Y+ E+ +VH D+ A N+LL ++D+GLS + N+ + Q + + Sbjct: 138 RMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRK 197 Query: 534 ---WPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGER 590 +++ + + S +SDV G M G+ P+ V K Sbjct: 198 GHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLC-GKLPWEQNLKDPVAVQTAKTNL 256 Query: 591 MG---------CPAGCP-REMYDLMNLCWTYDVENRPGFAAVELRLRNY 629 + P+G E+ + + + +P + A++ L + Sbjct: 257 LDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNPH 305 >2RSV-A nrPDB Length = 403 Score = 76.2 bits (186), Expect = 4e-14, Method: Composition-based stats. Identities = 46/261 (17%), Positives = 98/261 (37%), Gaps = 41/261 (15%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNP----- 430 +G G FG + + V + A ++K E P+ L E Q+ P Sbjct: 49 PIGQGGFGCIYLADMNSSESVGSDAPCVVKVE---PSDNGPLFTELKFYQRAAKPEQIQK 105 Query: 431 YI----VRMIGICE-----------AESWMLVMEMAELGPLNKYLQQN-RHVKDKNIIEL 474 +I ++ +G+ + ++M+ L K + N + K +++L Sbjct: 106 WIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQL 164 Query: 475 VHQVSMGMKYLEESNFVHRDLAARNVLLV--TQHYAKISDFGLSKALRADENYYKAQTHG 532 ++ ++Y+ E +VH D+ A N+LL + D+GL+ + + + + Sbjct: 165 SLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDP 224 Query: 533 K----WPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG-MKGSEVTAMLEK 587 K +++ + + N S + D+ G M + + G P+ +K + + Sbjct: 225 KRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDNLKDPKYVRDSKI 283 Query: 588 GERMGCPAGCPREMYDLMNLC 608 R + LM+ C Sbjct: 284 RYR--------ENIASLMDKC 296 >2LAV-A nrPDB Length = 361 Score = 76.2 bits (186), Expect = 4e-14, Method: Composition-based stats. Identities = 46/261 (17%), Positives = 98/261 (37%), Gaps = 41/261 (15%) Query: 376 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNP----- 430 +G G FG + + V + A ++K E P+ L E Q+ P Sbjct: 42 PIGQGGFGCIYLADMNSSESVGSDAPCVVKVE---PSDNGPLFTELKFYQRAAKPEQIQK 98 Query: 431 YI----VRMIGICE-----------AESWMLVMEMAELGPLNKYLQQN-RHVKDKNIIEL 474 +I ++ +G+ + ++M+ L K + N + K +++L Sbjct: 99 WIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF-GSDLQKIYEANAKRFSRKTVLQL 157 Query: 475 VHQVSMGMKYLEESNFVHRDLAARNVLLV--TQHYAKISDFGLSKALRADENYYKAQTHG 532 ++ ++Y+ E +VH D+ A N+LL + D+GL+ + + + + Sbjct: 158 SLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDP 217 Query: 533 K----WPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG-MKGSEVTAMLEK 587 K +++ + + N S + D+ G M + + G P+ +K + + Sbjct: 218 KRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWEDNLKDPKYVRDSKI 276 Query: 588 GERMGCPAGCPREMYDLMNLC 608 R + LM+ C Sbjct: 277 RYR--------ENIASLMDKC 289 >5GZ9-A nrPDB Length = 305 Score = 74.3 bits (181), Expect = 2e-13, Method: Composition-based stats. Identities = 47/287 (16%), Positives = 95/287 (33%), Gaps = 57/287 (19%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K +G G V ++ K VA+ + +K++ L +++ L + ++V Sbjct: 40 KRVGEGAVKRVFLSEWKEHK----VAL----SRLTRLEMKEDFLHGLQMLKSLQSEHVVT 91 Query: 435 MIGICEAESWMLVMEMAELGPLNKY-----LQQNRHV-KDKNIIELVHQVSMGMKYLEES 488 ++G CE + +L E LG L+ L + + V ++ ++L + + YL S Sbjct: 92 LVGYCEEDGTIL-TEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSIINYLHHS 150 Query: 489 NFVHRDLAARN--------VLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540 R + N LL + +D + D H + + A Sbjct: 151 PLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLIKCGHRELHGDFVA 210 Query: 541 PECI------------NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKG 588 PE + ++ K D+W + P S +G Sbjct: 211 PEQLWPYGEDTPFQDDLMPSYNEKVDIW-------------KIP----DVSSFLLGHVEG 253 Query: 589 ERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 M ++D+ C + RP V + ++ + + Sbjct: 254 SDMVR-----FHLFDIHKACKSQIPAERPTAQNVLDAYQRVFHSLRD 295 >4IX6-A nrPDB Length = 350 Score = 73.5 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 52/260 (20%), Positives = 85/260 (32%), Gaps = 66/260 (25%) Query: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLA-EANV 423 ++ K + + LGSGNFGTV +G ++ + V +LKN D +ELL E +V Sbjct: 16 VEPKDIRVLPGPLGSGNFGTVFRGVFKGDQDV------VLKNAKADVMAAEELLECEMDV 69 Query: 424 MQQLDNPY----IVRMIGICE--------------AESWML---------VMEMAELG-- 454 + + R +G E E L V + G Sbjct: 70 NYHV-HANAKGTCARFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTA 128 Query: 455 PLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQ--HYAKISD 512 PL + + + + ++ + L E VHRD+ N++ + K+ D Sbjct: 129 PLATAMACADATELGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLID 188 Query: 513 FGLSK-ALRADENYYKAQTHGKWPVKW--------YAP--------------ECINYYKF 549 G + L E G ++ P E +F Sbjct: 189 LGAAALCLPLPETLNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRF 248 Query: 550 SSKSDVWSFGVLMWEAFSYG 569 S WS G +M + G Sbjct: 249 DS----WSAGCVMLQLAVVG 264 >2CRH-A nrPDB Length = 138 Score = 73.1 bits (178), Expect = 3e-13, Method: Composition-based stats. Identities = 26/103 (25%), Positives = 41/103 (39%), Gaps = 8/103 (7%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74 ++ G + R AE L SDG +L+RQ FA+S+ + + H I G Y Sbjct: 28 WYAGPMERAGAESIL--ANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMT-AEGLY 84 Query: 75 AIAGGRTHASPADLCHYHSQESDGLV-----CLLKKPFNRPQG 112 I + +L ++ Q S L+ PF P+ Sbjct: 85 RITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEK 127 Score = 68.9 bits (167), Expect = 6e-12, Method: Composition-based stats. Identities = 24/84 (28%), Positives = 42/84 (50%), Gaps = 4/84 (4%) Query: 166 MPWFHGKISREESEQIVLIGSKTNGKFLIRAR-DNNGSYALCLLHEGKVLHYRIDKDKTG 224 W+ G + R +E I+ ++++G FL+R R + +A+ + + +V H +I G Sbjct: 26 HLWYAGPMERAGAESIL--ANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMT-AEG 82 Query: 225 KLSIPEGKKFDTLWQLVEHYSYKA 248 I E K F L +LVE Y + Sbjct: 83 LYRITEKKAFRGLTELVEFYQQNS 106 >2KK6-A nrPDB Length = 116 Score = 73.1 bits (178), Expect = 3e-13, Method: Composition-based stats. Identities = 20/88 (22%), Positives = 35/88 (39%), Gaps = 6/88 (6%) Query: 9 SANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIER 68 ++ G I R EA++ L + G +L+R+S G + LSV + H+ I+ Sbjct: 13 PLAEQDWYHGAIPRIEAQELLKKQ----GDFLVRESHGKPGEYVLSVYSDGQRRHFIIQY 68 Query: 69 ELNGTYAIAGGRTHASPADLCHYHSQES 96 N G ++ L +H Sbjct: 69 VDNMYRF--EGTGFSNIPQLIDHHYTTK 94 Score = 71.6 bits (174), Expect = 9e-13, Method: Composition-based stats. Identities = 26/102 (25%), Positives = 44/102 (43%), Gaps = 11/102 (10%) Query: 165 KMPWFHGKISREESEQIVLIGSKTNGKFLIRARD-NNGSYALCLLHEGKVLHYRIDKDKT 223 + W+HG I R E+++++ G FL+R G Y L + +G+ H+ I Sbjct: 16 EQDWYHGAIPRIEAQELLKKQ----GDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDN 71 Query: 224 GKLSIPEGKKFDTLWQLVEHYSYKADGLLR----VLTVPCQK 261 EG F + QL++H+ + + VL P K Sbjct: 72 MYRF--EGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPK 111 >5GZA-A nrPDB Length = 290 Score = 73.1 bits (178), Expect = 4e-13, Method: Composition-based stats. Identities = 54/289 (18%), Positives = 97/289 (33%), Gaps = 72/289 (24%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K +G G V +Q + VA+ +L ++ D+ L ++++ L + ++V Sbjct: 31 KLIGQGAVKKVYLSEWQ----GQKVALSVLSSD----QYADDFLHGLSMLRALQSSHVVT 82 Query: 435 MIGICEAESWMLVMEMAELGP---LNKYLQQNRHV---KDKNIIELVHQVSMGMKYLEES 488 ++G+CE ++ V E LG L+ L Q R+ ++L + YL S Sbjct: 83 LVGVCEEDAVF-VTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLAYLHSS 141 Query: 489 --NFVHRDLAARN--------VLLVTQHYAKISDFGLSKALRADENYYKAQTHGKW---- 534 R + N LL + L+ L A K K Sbjct: 142 PAGI--RVMCDSNDLHKTLSQFLLASDMRL------LANDLDALPEVEKGGLGVKCGHHE 193 Query: 535 -PVKWYAPECI------------NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 + APE + + K+D+W + P +V Sbjct: 194 LTGDFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW-------------KIP-------DV 233 Query: 582 TAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYY 630 T L G+ +G ++ + + C + RP V R+ Y Sbjct: 234 TRFLL-GDVLGGDVIHF-HLFQIYSECKRKEAHMRPTAREVLSVYRSVY 280 >2JII-A nrPDB Length = 352 Score = 72.7 bits (177), Expect = 4e-13, Method: Composition-based stats. Identities = 31/216 (14%), Positives = 80/216 (37%), Gaps = 20/216 (9%) Query: 436 IGICEAESWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGMKYLEESNFVHR 493 G+ + + LV+ L L + +++++++ ++ +++L E+ +VH Sbjct: 125 FGVHQDKYRFLVLPSL-GRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHG 183 Query: 494 DLAARNVLLV--TQHYAKISDFGLSKALRADENYYKAQTHGKWP----VKWYAPECINYY 547 ++ A N+ + Q ++ +G + + + P +++ + + Sbjct: 184 NVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGC 243 Query: 548 KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGC---------- 597 S +SD+ S G M + YG P+ + M +K + + P Sbjct: 244 GPSRRSDLQSLGYCMLKWL-YGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRP 302 Query: 598 PREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDV 633 + + + E +P +A + L D+ Sbjct: 303 SETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDL 338 >4O1O-A nrPDB Length = 717 Score = 72.4 bits (176), Expect = 6e-13, Method: Composition-based stats. Identities = 53/304 (17%), Positives = 108/304 (35%), Gaps = 67/304 (22%) Query: 325 PELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGT 384 P W EAL ++ P + K +++D + + E G Sbjct: 314 PPAENWKPQSSRWGEALKHLHRIWR-----PMIGKLK-IFIDEEYKIADTAE------GG 361 Query: 385 VKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLD-NPYIVRMIGICEAES 443 + G Y+ + VAVK + E + +Q N +V G E++ Sbjct: 362 IYLGLYED----QEVAVKRFSEGSTRGQ------QEVSCLQSSRANDNVVTFYG-SESDG 410 Query: 444 WML--VMEMAELGPLNKYLQQNR-----HVKDKNIIELVHQVSMGMKYLEESNFVHRDLA 496 L + + E L ++L +R + +D++ ++ + + L S + H+DL Sbjct: 411 SCLHVCLALCEY-TLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQ 469 Query: 497 ARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVW 556 +N+L+ +++ ++DF +KW K D+ Sbjct: 470 PQNILIDSKNGTFLADF-------------------DKSIKW------AEDPQKIKRDLE 504 Query: 557 SFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY--DVE 614 + G+L+ G + +K +++ G P E DL++ + +VE Sbjct: 505 ALGLLVLYVVKKGDISFETLKNQSFEEVIQ-----GSPD---EETRDLIHHLFHPGDNVE 556 Query: 615 NRPG 618 +R Sbjct: 557 DRLS 560 >2LCT-A nrPDB Length = 107 Score = 72.0 bits (175), Expect = 8e-13, Method: Composition-based stats. Identities = 29/107 (27%), Positives = 44/107 (41%), Gaps = 9/107 (8%) Query: 6 MADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYT 65 M D + HL ++ G + R AE L SDG +L+RQ FA+S+ + + H Sbjct: 3 MQDLSVHL-WYAGPMERAGAESIL--ANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIK 59 Query: 66 IERELNGTYAIAGGRTHASPADLCHYHSQESDGLV-----CLLKKPF 107 I G Y I + +L ++ Q S L+ PF Sbjct: 60 IMT-AEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPF 105 Score = 69.7 bits (169), Expect = 4e-12, Method: Composition-based stats. Identities = 24/84 (28%), Positives = 42/84 (50%), Gaps = 4/84 (4%) Query: 166 MPWFHGKISREESEQIVLIGSKTNGKFLIRAR-DNNGSYALCLLHEGKVLHYRIDKDKTG 224 W+ G + R +E I+ ++++G FL+R R + +A+ + + +V H +I G Sbjct: 9 HLWYAGPMERAGAESIL--ANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMT-AEG 65 Query: 225 KLSIPEGKKFDTLWQLVEHYSYKA 248 I E K F L +LVE Y + Sbjct: 66 LYRITEKKAFRGLTELVEFYQQNS 89 >6BHC-A nrPDB Length = 438 Score = 69.3 bits (168), Expect = 5e-12, Method: Composition-based stats. Identities = 44/276 (15%), Positives = 97/276 (35%), Gaps = 51/276 (18%) Query: 385 VKKGYYQMKKVVKTVAVKILKNEANDPAL-------KDELLAEANVMQQLDN-----PYI 432 V K + AVKI K++A + + L N+ Q + P Sbjct: 72 VYYTASYAKDPLNNYAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPN- 130 Query: 433 VRMIGICEAE-----SWMLVMEMAELGPLNKYLQ-------QNRHVKDKNIIELVHQVSM 480 R++ + +++ + +++ ++ + ++ + L+ Q+ Sbjct: 131 -RLLPWEDPSKKQRSHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCS 189 Query: 481 GMKYLEESNFVHRDLAARNVLLVT---QHYAKISDFGLS----------KALRADENYYK 527 G+++L+ + H DL N+LLV A+ FG + + + ++ + K Sbjct: 190 GLEHLKPYHVTHCDLRLENLLLVHYQPGGTAQ--GFGPAEPTPTSSYPTRLIVSNFSQAK 247 Query: 528 AQTHGKWPV-----KWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVT 582 ++H P APE I ++ K D + G+L++E P+ Sbjct: 248 QKSHLVDPEILRDQSRLAPEIITATQY-KKCDEFQTGILIYEMLHL-PNPF-DENPELKE 304 Query: 583 AMLEKGERMGCP--AGCPREMYDLMNLCWTYDVENR 616 + + P + R + L + + R Sbjct: 305 REYTRADLPRIPFRSPYSRGLQQLASCLLNPNPSER 340 >5DMZ-A nrPDB Length = 365 Score = 66.6 bits (161), Expect = 3e-11, Method: Composition-based stats. Identities = 33/233 (14%), Positives = 74/233 (31%), Gaps = 31/233 (13%) Query: 358 IRPKEVYLDRKLLTLEDKELGSGNFGTVKKGY---YQMKKVVKTVAVKILKNEANDPALK 414 I+PK + L LG G F V + K + +K+ PA Sbjct: 54 IKPKTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKV-----QKPANP 108 Query: 415 DELLAEANVMQQLD----NPYIVRMIGICE-AESWMLVMEMAELGPLNKYLQQNRHVKDK 469 E +M++L + + ++ +LV E+ G L + ++ +K Sbjct: 109 WEFYIGTQLMERLKPSMQHMF-MKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEK 167 Query: 470 N-----IIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHY-----------AKISDF 513 +I ++ ++ + + +H D+ N +L + D Sbjct: 168 VMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDL 227 Query: 514 GLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAF 566 G S ++ T + E ++ ++ + D + ++ Sbjct: 228 GQSIDMKLFPKG-TIFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCML 279 >3CXL-A nrPDB Length = 463 Score = 64.6 bits (156), Expect = 1e-10, Method: Composition-based stats. Identities = 24/87 (27%), Positives = 46/87 (52%), Gaps = 12/87 (13%) Query: 16 FFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYA 75 F G I+RE A+ L+ +++G YL+R+S+ G + L++ G + ++ + +G + Sbjct: 54 FHGMISREAADQLLI---VAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYY--DGKHF 108 Query: 76 IAGGRTHASPADLCHYHSQESDGLVCL 102 + G + S DL +DGL+ L Sbjct: 109 V-GEKRFESIHDLV------TDGLITL 128 Score = 62.7 bits (151), Expect = 4e-10, Method: Composition-based stats. Identities = 36/130 (27%), Positives = 60/130 (46%), Gaps = 22/130 (16%) Query: 131 YVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMP-----WFHGKISREESEQIVLIG 185 Y + W L+Q + P ++ T E P FHG ISRE ++Q++++ Sbjct: 15 YFQGVWKSYLYQLQQ----EAPHPRRITCTCEVENRPKYYGREFHGMISREAADQLLIVA 70 Query: 186 SKTNGKFLIRAR-DNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHY 244 G +LIR G+Y L L + ++R+ D GK + E K+F+++ LV Sbjct: 71 ---EGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYD--GKHFVGE-KRFESIHDLVT-- 122 Query: 245 SYKADGLLRV 254 DGL+ + Sbjct: 123 ----DGLITL 128 >3QWY-A nrPDB Length = 308 Score = 63.9 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 30/104 (28%), Positives = 45/104 (43%), Gaps = 12/104 (11%) Query: 1 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVA---H 57 M ++G D F+F ++REEA L + +S G +L+R S + G ++L+V Sbjct: 30 MTTNG-FDPFEWRSFYFPGMSREEAHKLLGEPQVSIGTFLMRDS-SRPGEYSLTVREADE 87 Query: 58 GRKAHHYTIER-------ELNGTYAIAGGRTHASPADLCHYHSQ 94 G HY IER IA PA L H+ + Sbjct: 88 GNAVCHYLIERGEPKEDGTAAAGVKIANQSFPDIPALLNHFKMR 131 Score = 61.2 bits (147), Expect = 1e-09, Method: Composition-based stats. Identities = 21/102 (20%), Positives = 43/102 (42%), Gaps = 12/102 (11%) Query: 156 KLIATTAHEKMPW---FHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGK 212 + + T + W + +SREE+ +++ + G FL+R G Y+L + + Sbjct: 28 QQMTTNGFDPFEWRSFYFPGMSREEAHKLLGEPQVSIGTFLMRDSSRPGEYSLTVREADE 87 Query: 213 ---VLHYRIDK---DKTGKLSIP---EGKKFDTLWQLVEHYS 245 V HY I++ + G + + F + L+ H+ Sbjct: 88 GNAVCHYLIERGEPKEDGTAAAGVKIANQSFPDIPALLNHFK 129 >6EWX-A nrPDB Length = 484 Score = 63.9 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 35/240 (14%), Positives = 75/240 (31%), Gaps = 57/240 (23%) Query: 438 ICEAESWMLVMEMAELGPLNKYLQQ-------NRHVKDKNIIELVHQVSMGMKYLEESNF 490 E + +++ + +++ V ++ + L+ Q+ G+++L+E Sbjct: 172 AQEQDCVVVITREVPHQTASDFVRDSVASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGI 231 Query: 491 VHRDLAARNVLLVTQH-----------------------------------------YAK 509 +HRDL N+LLV + Sbjct: 232 IHRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCPSAAPAATTACQGGPGEKHLPRLI 291 Query: 510 ISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYG 569 IS+F L + K APE ++ ++ K D + G+L++E Sbjct: 292 ISNF-LKAKQKPGGT---TNLQQKKSQARLAPEIVSASQY-RKFDEFQTGILIYELLHQ- 345 Query: 570 QKPYRGMKGSEVTAMLEKGERMGCP--AGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 627 P+ ++ + + P + + L +L D R + L+ Sbjct: 346 PNPFE-VRAQLRERDYRREDLPPLPTLSLYSPGLQQLAHLLLEADPIKRIRIGEAKRVLQ 404 >6G4J-A nrPDB Length = 315 Score = 62.7 bits (151), Expect = 5e-10, Method: Composition-based stats. Identities = 26/140 (18%), Positives = 51/140 (36%), Gaps = 25/140 (17%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 K+LG G G V + VA+K+ + + + +E NV++ V Sbjct: 32 KQLGKGANGIVYLA----ETSDGHVALKVSDDSLS-------ITSEVNVLKSFSKAQSVT 80 Query: 435 M-IGICEAESWML----------VMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMK 483 M + + + ME + L KY+ + I L+ Q+ + Sbjct: 81 MGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGA---EWIPVLMIQLLSSLS 137 Query: 484 YLEESNFVHRDLAARNVLLV 503 L + ++ DL N+++ Sbjct: 138 VLHQQGWIFGDLKPDNLIVT 157 >1XA6-A nrPDB Length = 466 Score = 62.3 bits (150), Expect = 5e-10, Method: Composition-based stats. Identities = 26/87 (29%), Positives = 46/87 (52%), Gaps = 12/87 (13%) Query: 16 FFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYA 75 F G I+RE+A++ L G +G Y+LR+S+ G + L++ G + +Y + +G + Sbjct: 58 FHGIISREQADELL---GGVEGAYILRESQRQPGCYTLALRFGNQTLNYRLFH--DGKHF 112 Query: 76 IAGGRTHASPADLCHYHSQESDGLVCL 102 + G + S DL +DGL+ L Sbjct: 113 V-GEKRFESIHDLV------TDGLITL 132 Score = 60.0 bits (144), Expect = 3e-09, Method: Composition-based stats. Identities = 36/131 (27%), Positives = 61/131 (46%), Gaps = 22/131 (16%) Query: 130 EYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMP-----WFHGKISREESEQIVLI 184 EY W L+Q + P+ +++I E P FHG ISRE++++++ Sbjct: 18 EYQPPIWKSYLYQLQQ----EAPRPKRIICPREVENRPKYYGREFHGIISREQADELL-- 71 Query: 185 GSKTNGKFLIRAR-DNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEH 243 G +++R G Y L L + L+YR+ D GK + E K+F+++ LV Sbjct: 72 -GGVEGAYILRESQRQPGCYTLALRFGNQTLNYRLFHD--GKHFVGE-KRFESIHDLVT- 126 Query: 244 YSYKADGLLRV 254 DGL+ + Sbjct: 127 -----DGLITL 132 >3ENH-A nrPDB Length = 540 Score = 61.2 bits (147), Expect = 1e-09, Method: Composition-based stats. Identities = 32/190 (16%), Positives = 70/190 (36%), Gaps = 33/190 (17%) Query: 346 EVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVK-IL 404 Y + + I+ + K + + +G G +K + + V +K + Sbjct: 317 PNYRTDMVEVNWIK----EIKGKKRKIPEHLIGKGAEADIK----RDSYLDFDVIIKERV 368 Query: 405 KNEANDPALKDELL-----AEANVMQQLDN-----PYIVRMIGICEAESWMLVMEMAELG 454 K D L + + EA + + + PYI + + ++ ++M Sbjct: 369 KKGYRDERLDENIRKSRTAREARYLALVKDFGIPAPYI---FDV-DLDNKRIMMSYINGK 424 Query: 455 PLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFG 514 ++ N +++ +++ + L +++ +H DL N + Y I DFG Sbjct: 425 LAKDVIEDN--------LDIAYKIGEIVGKLHKNDVIHNDLTTSNFIFDKDLY--IIDFG 474 Query: 515 LSKALRADEN 524 L K DE+ Sbjct: 475 LGKISNLDED 484 >2VIF-A nrPDB Length = 141 Score = 59.6 bits (143), Expect = 4e-09, Method: Composition-based stats. Identities = 25/80 (31%), Positives = 36/80 (45%), Gaps = 6/80 (7%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74 +++G ITR EAE L + DG +L+R S + +LS K H IE NG + Sbjct: 26 WYWGPITRWEAEGKL--ANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIE-HSNGRF 82 Query: 75 AIAGG---RTHASPADLCHY 91 + H S DL + Sbjct: 83 SFYEQPDVEGHTSIVDLIEH 102 Score = 57.7 bits (138), Expect = 2e-08, Method: Composition-based stats. Identities = 25/84 (29%), Positives = 41/84 (48%), Gaps = 9/84 (10%) Query: 165 KMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSY--ALCLLHEGKVLHYRIDKDK 222 K W+ G I+R E+E + + +G FL+R + Y +L GK LH RI+ Sbjct: 23 KQGWYWGPITRWEAE--GKLANVPDGSFLVRDSSD-DRYLLSLSFRSHGKTLHTRIE-HS 78 Query: 223 TGKLSI---PEGKKFDTLWQLVEH 243 G+ S P+ + ++ L+EH Sbjct: 79 NGRFSFYEQPDVEGHTSIVDLIEH 102 >4CI6-B nrPDB Length = 643 Score = 59.3 bits (142), Expect = 5e-09, Method: Composition-based stats. Identities = 44/274 (16%), Positives = 90/274 (32%), Gaps = 51/274 (18%) Query: 383 GTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL-----DNPYIVRMIG 437 G + K + VA + + L AE + + +P + + G Sbjct: 56 GESHISIIETKDKQRLVA------KIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHG 109 Query: 438 ---ICEAESWM--LVMEMAEL-------GPLNKYLQQNRHVKDK---NIIELVHQVSMGM 482 + + L+M+ + L +Q + + I + H++ Sbjct: 110 MAVVPYGNRYYYALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVT 169 Query: 483 KYLEESNFVHRDLAARNVLLV-TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAP 541 +L ++ VH D+ NV+ + D GL + + + + AP Sbjct: 170 NHLAKAGIVHNDIKPGNVVFDRASGEPVVIDLGL--------HSRSGEQPKGFTESFKAP 221 Query: 542 EC-INYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600 E + S KSDV+ +++ G++G E ++ + + P Sbjct: 222 ELGVGNLGASEKSDVF---LVVSTLL-------HGIEGFEKDPEIKPNQGLRFITSEPAH 271 Query: 601 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVV 634 + D +RPG A VE + D++ Sbjct: 272 VMDE-----NGYPIHRPGIAGVETAYTRFITDIL 300 >4OAU-C nrPDB Length = 699 Score = 58.5 bits (140), Expect = 1e-08, Method: Composition-based stats. Identities = 39/207 (18%), Positives = 74/207 (35%), Gaps = 30/207 (14%) Query: 336 PQREALPMDTEVYESPYADPEEI-RPK----EVYLDRKLLTLEDKELGSGNFGTVKKGYY 390 P E + + + D I RP + ++D K + E G + G+Y Sbjct: 311 PPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSE------GGIYLGFY 364 Query: 391 QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLD-NPYIVRMIGICEAESWMLV-M 448 + + VAVK + E + +Q N ++V G + V + Sbjct: 365 EK----QEVAVKTFCEGSP------RAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCV 414 Query: 449 EMAELGPLNKYLQQNRHVKDKN-----IIELVHQVSMGMKYLE-ESNFVHRDLAARNVLL 502 + E L L +R +N ++ + ++ L + H+DL +N+L+ Sbjct: 415 TLCEQ-TLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILI 473 Query: 503 VTQHYAKISDFGLSKALRADENYYKAQ 529 ++ A ++DF S D K Sbjct: 474 DSKKAAHLADFDKSIKWAGDPQEVKRD 500 >4AZW-A nrPDB Length = 471 Score = 54.6 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 33/150 (22%), Positives = 56/150 (37%), Gaps = 18/150 (12%) Query: 382 FGT--VKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQ----LDNPYIVRM 435 FG V K +Y A K EL E + Q D P + + Sbjct: 258 FGEDYVCKFFYYDMPHGILTA-------EESQRNKHELHNEIKFLTQPPAGFDAPAV--L 308 Query: 436 IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDL 495 A+S LVME L+ L + + +++ + + LE+ F H D+ Sbjct: 309 AHGENAQSGWLVMEKLPGRLLSDMLAAGEEIDRE---KILGSLLRSLAALEKKGFWHDDV 365 Query: 496 AARNVLLVTQHYAKISDFGLSKALRADENY 525 NV++ + +A++ DFG D ++ Sbjct: 366 RPWNVMVDARQHARLIDFGSIVTTPQDCSW 395 >5VE6-A nrPDB Length = 492 Score = 53.9 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 14/74 (18%), Positives = 33/74 (44%), Gaps = 7/74 (9%) Query: 438 ICEAESWMLVMEMAELGPLNKYLQQ-------NRHVKDKNIIELVHQVSMGMKYLEESNF 490 E + +++ + +++ ++ + L+ Q+ G+++L+E Sbjct: 170 AQEQDCVVVITREVPHQTASDFVRDSAASHQAEPEAYERRVCFLLLQLCNGLEHLKEHGI 229 Query: 491 VHRDLAARNVLLVT 504 +HRDL N+LLV Sbjct: 230 IHRDLCLENLLLVH 243 >4AZV-A nrPDB Length = 569 Score = 53.5 bits (127), Expect = 3e-07, Method: Composition-based stats. Identities = 33/150 (22%), Positives = 56/150 (37%), Gaps = 18/150 (12%) Query: 382 FGT--VKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQ----LDNPYIVRM 435 FG V K +Y A K EL E + Q D P + + Sbjct: 258 FGEDYVCKFFYYDMPHGILTA-------EESQRNKYELHNEIKFLTQPPAGFDAPAV--L 308 Query: 436 IGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDL 495 A+S LVME L+ L + + +++ + + LE+ F H D+ Sbjct: 309 AHGENAQSGWLVMEKLPGRLLSDMLAAGEEIDRE---KILGSLLRSLAALEKQGFWHDDV 365 Query: 496 AARNVLLVTQHYAKISDFGLSKALRADENY 525 NV++ + +A++ DFG D ++ Sbjct: 366 RPWNVMVDARQHARLIDFGSIVTTPQDCSW 395 >6M7Z-A nrPDB Length = 319 Score = 53.1 bits (126), Expect = 4e-07, Method: Composition-based stats. Identities = 29/220 (13%), Positives = 67/220 (30%), Gaps = 36/220 (16%) Query: 428 DNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 487 +P ++ +G + G + L+ R ++ L + +K L Sbjct: 105 RSPLLLPSLGEYRGAFLTYIFHPLSKGLVGDMLETGR--SHPDVQVLAANMVAALKSLHN 162 Query: 488 SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPEC---- 543 +HR + + ++ + + + + + + APE Sbjct: 163 LGLLHRSIELNSFSVLPDGTVVLGGLDTAAPIGTETRLWVGFFGQET-----APEIDRNF 217 Query: 544 -----INYYKFSSKSDVWSFGVL---MWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPA 595 + + + KSDV+S GV + + G L +R Sbjct: 218 LADLALTQGRHTVKSDVYSLGVAFRNLVQLLGNG--------------NLGPEDRGAVRQ 263 Query: 596 GCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 + L + NRP +E +++ ++ +N Sbjct: 264 DHLELLDKLSQKMIEEEPGNRPT---IEEIMKDPLFEGLN 300 >6G38-A nrPDB Length = 357 Score = 50.8 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 30/174 (17%), Positives = 59/174 (33%), Gaps = 54/174 (31%) Query: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEAND------PALKDELLAEANVMQQL- 427 +++G G FG V + VA+KI+ E D +E+L E + ++L Sbjct: 47 EKIGEGVFGEVFQTIADHTP----VAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELS 102 Query: 428 ----------------DNPYIVR------MI-----------------GICEAESWMLVM 448 ++ + V+ ++ + + +V+ Sbjct: 103 LLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVL 162 Query: 449 EMAELG-PLNKYLQQNRHVKDKNIIELVHQVSMGMKYLE-ESNFVHRDLAARNV 500 E G L + + + ++HQ++ + E F HRDL NV Sbjct: 163 EFEFGGIDLEQ--MRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNV 214 >6C7Y-B nrPDB Length = 117 Score = 50.0 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 23/93 (24%), Positives = 38/93 (40%), Gaps = 5/93 (5%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74 F++G +T A + L +G +L+R S FA+SV I + G + Sbjct: 28 FYWGPLTVSAAHEKLKSE--PEGTFLIRDSTQKNCFFAISVKTATGPTSIRINFQT-GRF 84 Query: 75 AIAG-GRTHASPADLCHYH-SQESDGLVCLLKK 105 ++ G T L ++ S LV L+K Sbjct: 85 SLDGSKETFDCLFKLLEHYLSSPRKVLVTPLRK 117 Score = 48.9 bits (115), Expect = 7e-06, Method: Composition-based stats. Identities = 24/95 (25%), Positives = 44/95 (46%), Gaps = 8/95 (8%) Query: 169 FHGKISREESEQIVLIGSKTNGKFLIRARDNNGS-YALCLLHEGKVLHYRIDKDKTGKLS 227 + G ++ + + + S+ G FLIR +A+ + RI+ +TG+ S Sbjct: 29 YWGPLTVSAAHE--KLKSEPEGTFLIRDSTQKNCFFAISVKTATGPTSIRINF-QTGRFS 85 Query: 228 IPE-GKKFDTLWQLVEHYSYKADGLLRVLTVPCQK 261 + + FD L++L+EHY +VL P +K Sbjct: 86 LDGSKETFDCLFKLLEHY---LSSPRKVLVTPLRK 117 >4JGH-A nrPDB Length = 173 Score = 50.0 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 21/109 (19%), Positives = 43/109 (39%), Gaps = 16/109 (14%) Query: 150 QKP--QLEKLIATTAHEKMP-WFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSY--A 204 P Q +L W+ G ++ E+++ + G FLIR ++ Y Sbjct: 2 MDPEFQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEA--PEGTFLIRDSSHS-DYLLT 58 Query: 205 LCLLHEGKVLHYRIDKDKTGKLSIPEG-------KKFDTLWQLVEHYSY 246 + + + RI+ + GK + K+FD++ L+++Y Sbjct: 59 ISVKTSAGPTNLRIEY-QDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQ 106 Score = 46.9 bits (110), Expect = 3e-05, Method: Composition-based stats. Identities = 18/87 (20%), Positives = 37/87 (42%), Gaps = 10/87 (11%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74 +++G++T EA++ L + +G +L+R S + +SV + IE + G + Sbjct: 23 WYWGSMTVNEAKEKLKEA--PEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQD-GKF 79 Query: 75 AIAGG-------RTHASPADLCHYHSQ 94 + + S L Y+ Q Sbjct: 80 RLDSIICVKSKLKQFDSVVHLIDYYVQ 106 >2BBU-A nrPDB Length = 164 Score = 48.9 bits (115), Expect = 6e-06, Method: Composition-based stats. Identities = 24/121 (19%), Positives = 41/121 (33%), Gaps = 12/121 (9%) Query: 10 ANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERE 69 F++ +T EA L+ G +L+R S + F LSV + I+ E Sbjct: 20 LQESGFYWSAVTGGEAN--LLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCE 77 Query: 70 LNGTYAI-------AGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFED 122 G++++ L H++ L P P P+ P + Sbjct: 78 G-GSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPGTPSFSL--PPTEPSSEVPEQPPAQA 134 Query: 123 L 123 L Sbjct: 135 L 135 Score = 45.8 bits (107), Expect = 5e-05, Method: Composition-based stats. Identities = 26/115 (22%), Positives = 44/115 (38%), Gaps = 18/115 (15%) Query: 178 SEQIVLIGSKTNGKFLIRARDNNGS-YALCLLHEGKVLHYRIDKDKTGKLSI-------P 229 E +L+ ++ G FLIR + + L + + + RI + + G S+ Sbjct: 33 GEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRI-QCEGGSFSLQSDPRSTQ 91 Query: 230 EGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQ---LPGSHP 281 +FD + +LV HY L T+ + +P LPGS P Sbjct: 92 PVPRFDCVLKLVHHYMPPPGTPSFSL------PPTEPSSEVPEQPPAQALPGSTP 140 >4CYJ-A nrPDB Length = 438 Score = 48.9 bits (115), Expect = 8e-06, Method: Composition-based stats. Identities = 24/148 (16%), Positives = 54/148 (36%), Gaps = 22/148 (14%) Query: 382 FGT---VKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGI 438 FG V K Q + + A++ L E + +L +++ N IV + + Sbjct: 65 FGYPSWVYKA--QNSRNGRHYALRRL--EGYRLTNEKAILNVMKDWKKIKNASIVTIHEV 120 Query: 439 CEAESW-----MLVMEMAELG-PLNKY----LQQNRH-----VKDKNIIELVHQVSMGMK 483 + + + L L ++ + NR+ V + I + Q++ +K Sbjct: 121 FTTREFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALK 180 Query: 484 YLEESNFVHRDLAARNVLLVTQHYAKIS 511 + + R L ++L + ++S Sbjct: 181 TIHSNRLAARCLEPSKIILTDINRIRLS 208 >6C5X-D nrPDB Length = 164 Score = 48.1 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 30/105 (28%), Positives = 42/105 (40%), Gaps = 14/105 (13%) Query: 183 LIGSKTNGKFLIRARDNNGSY-ALCLLHEGKVLHYRIDKDKTGKLSIPEGKK-FDTLWQL 240 + S+ G FLIR + A+ + + + RI GK S+ K+ F L+QL Sbjct: 45 KLKSEPIGTFLIRDSKQKNCFFAISVKTARETVSIRIKFHA-GKFSLDGSKELFSCLFQL 103 Query: 241 VEHYSYKADGL---------LRVLTVPCQKI--GTQGNVNFGGRP 274 VEHY + LR L C+K T G N P Sbjct: 104 VEHYMTSPKKMLVSPLRKVRLRPLQELCRKSILATFGRQNLDSIP 148 Score = 47.3 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 27/110 (24%), Positives = 45/110 (40%), Gaps = 8/110 (7%) Query: 3 SSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAH 62 +S M D+ F++G + A D L G +L+R S+ FA+SV R+ Sbjct: 23 TSSMLDTCG---FYWGPMDVNVAHDKLKSE--PIGTFLIRDSKQKNCFFAISVKTARETV 77 Query: 63 HYTIERELNGTYAIAG-GRTHASPADLCHYHSQESDG-LVCLLKKPFNRP 110 I+ G +++ G + L ++ LV L+K RP Sbjct: 78 SIRIKFHA-GKFSLDGSKELFSCLFQLVEHYMTSPKKMLVSPLRKVRLRP 126 >4GL9-E nrPDB Length = 143 Score = 46.5 bits (109), Expect = 4e-05, Method: Composition-based stats. Identities = 18/75 (24%), Positives = 33/75 (44%), Gaps = 9/75 (12%) Query: 178 SEQIVLIGSKTNGKFLIRARDNNGS-YALCLLHEGKVLHYRIDKDKTGKLSI-------P 229 E +L+ ++ G FLIR + + L + + + RI + + G S+ Sbjct: 38 GEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRI-QCEGGSFSLQSDPRSTQ 96 Query: 230 EGKKFDTLWQLVEHY 244 +FD + +LV HY Sbjct: 97 PVPRFDCVLKLVHHY 111 Score = 45.8 bits (107), Expect = 6e-05, Method: Composition-based stats. Identities = 18/90 (20%), Positives = 33/90 (36%), Gaps = 10/90 (11%) Query: 10 ANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERE 69 F++ +T EA L+ G +L+R S + F LSV + I+ E Sbjct: 25 LQESGFYWSAVTGGEAN--LLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCE 82 Query: 70 LNGTYAI-------AGGRTHASPADLCHYH 92 G++++ L H++ Sbjct: 83 G-GSFSLQSDPRSTQPVPRFDCVLKLVHHY 111 >2HMH-A nrPDB Length = 152 Score = 46.2 bits (108), Expect = 5e-05, Method: Composition-based stats. Identities = 18/75 (24%), Positives = 33/75 (44%), Gaps = 9/75 (12%) Query: 178 SEQIVLIGSKTNGKFLIRARDNNGS-YALCLLHEGKVLHYRIDKDKTGKLSI-------P 229 E +L+ ++ G FLIR + + L + + + RI + + G S+ Sbjct: 44 GEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRI-QCEGGSFSLQSDPRSTQ 102 Query: 230 EGKKFDTLWQLVEHY 244 +FD + +LV HY Sbjct: 103 PVPRFDCVLKLVHHY 117 Score = 45.4 bits (106), Expect = 7e-05, Method: Composition-based stats. Identities = 18/90 (20%), Positives = 33/90 (36%), Gaps = 10/90 (11%) Query: 10 ANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERE 69 F++ +T EA L+ G +L+R S + F LSV + I+ E Sbjct: 31 LQESGFYWSAVTGGEAN--LLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCE 88 Query: 70 LNGTYAI-------AGGRTHASPADLCHYH 92 G++++ L H++ Sbjct: 89 G-GSFSLQSDPRSTQPVPRFDCVLKLVHHY 117 >4WWA-A nrPDB Length = 261 Score = 43.8 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 28/149 (18%), Positives = 55/149 (36%), Gaps = 28/149 (18%) Query: 391 QMKKVVKTVAVK-ILKNEANDPAL-----KDELLAEANVMQQLD-NPYI-VRMIGICEAE 442 + K + +K P + K L E+ ++ +L P + V + C+ Sbjct: 41 RAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIACDPY 100 Query: 443 SWMLVMEMA----ELG----PLNKYL--QQNRHVKD---KNIIELVHQVSMGMKYLEESN 489 + + +E G L +L D + ++ Q+ G+ L ++ Sbjct: 101 NGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQI--GL--LHWND 156 Query: 490 FVHRDLAARNVLLVTQH---YAKISDFGL 515 + H DL + N++LV + DFGL Sbjct: 157 YCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >2IZV-A nrPDB Length = 187 Score = 43.5 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 19/105 (18%), Positives = 40/105 (38%), Gaps = 8/105 (7%) Query: 161 TAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNG-SYALCLLHEGKVLHYRID 219 P + G + + +E ++ K G FL+R +++ + LH RI+ Sbjct: 29 LQINNNPCYWGVMDKYAAEALL--EGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIE 86 Query: 220 KDKTGK-LSIPEGKKFDT--LWQLVEHYSYKADGLL--RVLTVPC 259 + + F + + L+EHY + + +L+ P Sbjct: 87 QWNHNFSFDAHDPCVFHSPDITGLLEHYKDPSACMFFEPLLSTPL 131 Score = 43.1 bits (100), Expect = 4e-04, Method: Composition-based stats. Identities = 24/101 (23%), Positives = 42/101 (41%), Gaps = 8/101 (7%) Query: 10 ANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIER- 68 N+ P ++G + + AE L G +G +LLR S F++S ++ H IE+ Sbjct: 31 INNNPCYWGVMDKYAAEALL--EGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQW 88 Query: 69 ELNGTYAIAGGRTHASP--ADLCHYHSQESDGLVCLLKKPF 107 N ++ SP L ++ D C+ +P Sbjct: 89 NHNFSFDAHDPCVFHSPDITGLLEHYK---DPSACMFFEPL 126 >5YK0-A nrPDB Length = 452 Score = 43.5 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 29/177 (16%), Positives = 56/177 (31%), Gaps = 56/177 (31%) Query: 383 GTVKKGYYQMKKVVKTVAVKILKNEANDPALK---DELLAEANVMQQL------------ 427 G V K + + VAVK ++ D AL+ + V++QL Sbjct: 146 GQVHKAIWSD---GREVAVK-IQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDE 201 Query: 428 --------------------------DNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQ 461 D+P ++ + + +++ E E P+ + ++ Sbjct: 202 LVERTEMELDYRLEAANQRAFAKAYHDHPRF-QVPHVVASAPKVVIQEWIEGVPMAEIIR 260 Query: 462 ----QNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFG 514 + R + + EL + +H D N +L+ I DFG Sbjct: 261 HGTTEQRDLIGTLLAELTFDAPRRL------GLMHGDAHPGNFMLLPDGRMGIIDFG 311 >4CZY-B nrPDB Length = 429 Score = 43.1 bits (100), Expect = 4e-04, Method: Composition-based stats. Identities = 19/148 (12%), Positives = 47/148 (31%), Gaps = 33/148 (22%) Query: 386 KKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM------QQLDNPYIVRMIGIC 439 K Q K + A++ + L E ++ +++ N IV + Sbjct: 61 YKA--QNNKNGRHFALRRI--------EGYRLTNEKAILNVTKEWKKIINANIVTVHEAF 110 Query: 440 EAE-----SWMLVMEMAELGP-LNKY----------LQQNRHVKDKNIIELVHQVSMGMK 483 E S + V + L L + L+ + + + V Q++ + Sbjct: 111 TTEFFGDSSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALL 170 Query: 484 YLEESNFVHRDLAARNVLLVTQHYAKIS 511 + + R L + + + +++ Sbjct: 171 AIHNAKLAARCLELSKI-IWENNRIRLA 197 >4Z32-A nrPDB Length = 497 Score = 42.7 bits (99), Expect = 5e-04, Method: Composition-based stats. Identities = 27/114 (23%), Positives = 44/114 (38%), Gaps = 8/114 (7%) Query: 17 FGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGR----KAHHYTIERELNG 72 G I+ + A L + G GLY+LR S + L+ A R + H I + N Sbjct: 372 HGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENE 431 Query: 73 TYAIAGGRT-HASPADLCHYHSQE---SDGLVCLLKKPFNRPQGVQPKTGPFED 122 Y ++G + +S DL + + E SD ++ K + F Sbjct: 432 EYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRT 485 Score = 42.7 bits (99), Expect = 5e-04, Method: Composition-based stats. Identities = 21/100 (21%), Positives = 40/100 (40%), Gaps = 9/100 (9%) Query: 170 HGKISREESEQIVLIGSKTNGKFLIRAR-DNNGSYALCLLHEG----KVLHYRIDKDKTG 224 HG IS + + + G +++R + Y L E + H I K++ Sbjct: 372 HGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENE 431 Query: 225 KLSIPEGKK-FDTLWQLVEHYSY---KADGLLRVLTVPCQ 260 + ++ KK F +L L+ Y ++D ++ T C Sbjct: 432 EYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCP 471 >1TQM-A nrPDB Length = 282 Score = 42.3 bits (98), Expect = 7e-04, Method: Composition-based stats. Identities = 29/154 (18%), Positives = 57/154 (37%), Gaps = 26/154 (16%) Query: 374 DKELGSGNFGTVK--------KGYYQMKKVVKTVAVKILKNEAN------DPALKDELLA 419 K +G G V + + KV T + K +K + + Sbjct: 95 GKLMGEGKESAVFNCYSEKFGECVVKFHKVGHT-SFKKVKEKRDYGDLHFSVLAIRSARN 153 Query: 420 EANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVS 479 E +Q+L + ++ E ++ME+ + L + +N D+ + ++ +V+ Sbjct: 154 EFRALQKLQGLAVPKVYAW---EGNAVLMELIDAKELYRVRVEN---PDEVLDMILEEVA 207 Query: 480 MGMKYLEESNFVHRDLAARNVLLVTQHYAKISDF 513 + VH DL+ NVL+ + I DF Sbjct: 208 K---FYH-RGIVHGDLSQYNVLVSEEG-IWIIDF 236 >2CR4-A nrPDB Length = 126 Score = 42.3 bits (98), Expect = 7e-04, Method: Composition-based stats. Identities = 23/96 (23%), Positives = 36/96 (37%), Gaps = 7/96 (7%) Query: 177 ESEQIVLIGSKT----NGKFLIRARDNNGSYALCLLHE--GKVLHYRIDKDKTGKLSIPE 230 E E++ S +G + IR L + E KV +YRI +K K + Sbjct: 28 EVERLFKATSPRGEPQDGLYCIRNSSTKSGKVLVVWDETSNKVRNYRI-FEKDSKFYLEG 86 Query: 231 GKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQG 266 F ++ +VEHY + L + T G Sbjct: 87 EVLFVSVGSMVEHYHTHVLPSHQSLLLRHPYGYTSG 122 Score = 39.6 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 21/99 (21%), Positives = 32/99 (32%), Gaps = 10/99 (10%) Query: 24 EAEDYLVQ----GGMSDGLYLLRQSRNYLGGFALSV--AHGRKAHHYTIERELNGTYAIA 77 E E G DGLY +R S G L V K +Y I + + + + Sbjct: 28 EVERLFKATSPRGEPQDGLYCIRNSSTKSGK-VLVVWDETSNKVRNYRIFEKDS-KFYLE 85 Query: 78 GGRTHASPADLCHYHSQE--SDGLVCLLKKPFNRPQGVQ 114 G S + ++ LL+ P+ G Sbjct: 86 GEVLFVSVGSMVEHYHTHVLPSHQSLLLRHPYGYTSGPS 124 >3MAZ-A nrPDB Length = 125 Score = 41.1 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 14/86 (16%), Positives = 43/86 (50%), Gaps = 5/86 (5%) Query: 173 ISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHE---GKVLHYRIDKDKTGK-LSI 228 +SR+E+ ++ L + + G ++R ++ +Y++ + E ++ HY++ + + Sbjct: 22 VSRKEATEM-LQKNPSLGNMILRPGSDSRNYSITIRQEIDIPRIKHYKVMSVGQNYTIEL 80 Query: 229 PEGKKFDTLWQLVEHYSYKADGLLRV 254 + L+ +++++ + G LR Sbjct: 81 EKPVTLPNLFSVIDYFVKETRGNLRP 106 Score = 38.5 bits (88), Expect = 0.008, Method: Composition-based stats. Identities = 23/114 (20%), Positives = 45/114 (39%), Gaps = 6/114 (5%) Query: 7 ADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGR---KAHH 63 D N +P F ++R+EA + L Q S G +LR + +++++ + H Sbjct: 9 VDVLNPMPACFYTVSRKEATEML-QKNPSLGNMILRPGSDSR-NYSITIRQEIDIPRIKH 66 Query: 64 YTIEREL-NGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPK 116 Y + N T + T + + Y +E+ G + + G +P Sbjct: 67 YKVMSVGQNYTIELEKPVTLPNLFSVIDYFVKETRGNLRPFIASTDENTGQEPS 120 >3BYV-A nrPDB Length = 377 Score = 39.6 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 28/192 (14%), Positives = 64/192 (33%), Gaps = 33/192 (17%) Query: 456 LNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGL 515 L + ++ + ++L QV + L VH L +++L + ++ G Sbjct: 193 LLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLT--GF 250 Query: 516 SKALRADENYYKAQTHGKWPVKWYAPEC------INYYK-----FSSKSDVWSFGVLMWE 564 +R + + G P PE I+Y++ + D W+ G++++ Sbjct: 251 EHLVRDGARVVSSVSRGFEP-----PELEARRATISYHRDRRTLMTFSFDAWALGLVIYW 305 Query: 565 AFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENR-------- 616 + P + + + + P+ + L+ Y E+R Sbjct: 306 IWCA-DLPITKDAALGGSEWIFRSCK-----NIPQPVRALLEGFLRYPKEDRLLPLQAME 359 Query: 617 -PGFAAVELRLR 627 P + + L Sbjct: 360 TPEYEQLRTELS 371 >4BWP-A nrPDB Length = 448 Score = 38.8 bits (89), Expect = 0.006, Method: Composition-based stats. Identities = 10/109 (9%), Positives = 34/109 (31%), Gaps = 36/109 (33%) Query: 418 LAEANVMQQLDNPYIVRMIGICEAE-----SWMLVMEMAEL------------------- 453 + + ++L + +V++ + + S +LV + Sbjct: 94 MTLVEMWKKLQHTNVVQLREVFTTKAFGDNSLVLVYDYHPGSQTLLAKYFTPAPETNGYT 153 Query: 454 ----GPLNKYLQQNRH--------VKDKNIIELVHQVSMGMKYLEESNF 490 G + ++ + + I ++ Q++ G+K + + Sbjct: 154 DPFQGEARPFSHKSNMQRTSNGPLLPEATIWSIIMQLTAGLKAIHHAGL 202 >6G18-v nrPDB Length = 552 Score = 38.1 bits (87), Expect = 0.012, Method: Composition-based stats. Identities = 13/76 (17%), Positives = 27/76 (35%), Gaps = 8/76 (10%) Query: 439 CEAESWMLVMEMAELGPLNKYLQQNRHVKD-KNIIELVHQVSMGMKYLEESNFVHRDLAA 497 + +VME+ PL + +EL+ +++ +H D Sbjct: 179 IDYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLA-------NHGLIHGDFNE 231 Query: 498 RNVLLVTQHYAKISDF 513 N++L + + DF Sbjct: 232 FNLILDESDHITMIDF 247 >6FDN-A nrPDB Length = 320 Score = 37.7 bits (86), Expect = 0.015, Method: Composition-based stats. Identities = 13/76 (17%), Positives = 27/76 (35%), Gaps = 8/76 (10%) Query: 439 CEAESWMLVMEMAELGPLNKYLQQNRHVKD-KNIIELVHQVSMGMKYLEESNFVHRDLAA 497 + +VME+ PL + +EL+ +++ +H D Sbjct: 179 IDYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLA-------NHGLIHGDFNE 231 Query: 498 RNVLLVTQHYAKISDF 513 N++L + + DF Sbjct: 232 FNLILDESDHITMIDF 247 >1UUS-A nrPDB Length = 473 Score = 37.7 bits (86), Expect = 0.016, Method: Composition-based stats. Identities = 17/97 (17%), Positives = 37/97 (38%), Gaps = 15/97 (15%) Query: 17 FGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALS---VAHGRKAHHYTIEREL--- 70 +G + R+E D L G +++R S G F ++ V + HY ++ Sbjct: 355 YGYMGRQEVNDALQNQDP--GTFIIRFSERNPGQFGIAYIGVEMPARIKHYLVQPNDTAA 412 Query: 71 -NGTY--AIAGGRTHASPADLCHYHSQESDGLVCLLK 104 T+ ++ + +++++G LK Sbjct: 413 AKKTFPDFLSEHSQFVNLLQ----WTKDTNGAPRFLK 445 >2W1Z-A nrPDB Length = 368 Score = 37.3 bits (85), Expect = 0.022, Method: Composition-based stats. Identities = 25/169 (14%), Positives = 57/169 (33%), Gaps = 13/169 (7%) Query: 453 LGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISD 512 L + ++ + ++L Q+ L+ VH D RN+LL + ++ Sbjct: 175 GDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVRNILLDQRGGVFLT- 233 Query: 513 FGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF-----SSKSDVWSFGVLMWEAFS 567 G +R + G P + A + Y + + D W+ G+ ++ + Sbjct: 234 -GFEHLVRDGASAVSPIGRGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWIWC 292 Query: 568 YGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENR 616 + + + + + P+ + L+ Y E+R Sbjct: 293 ADLPNTEDAELGGIEWIYRRCK------NIPQPVRALLEGFLRYSKEDR 335 >3DZO-A nrPDB Length = 413 Score = 36.9 bits (84), Expect = 0.031, Method: Composition-based stats. Identities = 25/186 (13%), Positives = 60/186 (32%), Gaps = 22/186 (11%) Query: 456 LNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGL 515 L + ++ + ++L QV + L VH L +++L + ++ G Sbjct: 198 LLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLT--GF 255 Query: 516 SKALRADENYYKAQTHGKWPVKWYAPECINYYKF-----SSKSDVWSFGVLMWEAFSYGQ 570 +R + G P + A + + + + D W+ G+ ++ + Sbjct: 256 EHLVRDGASAVSPIGRGFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCA-D 314 Query: 571 KPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENR---------PGFAA 621 P + + + + P+ + L+ Y E+R P + Sbjct: 315 LPNTDDAALGGSEWIFRSCK-----NIPQPVRALLEGFLRYPKEDRLLPLQAMETPEYEQ 369 Query: 622 VELRLR 627 + L Sbjct: 370 LRTELS 375 >3Q60-A nrPDB Length = 371 Score = 36.5 bits (83), Expect = 0.032, Method: Composition-based stats. Identities = 24/176 (13%), Positives = 52/176 (29%), Gaps = 30/176 (17%) Query: 474 LVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGK 533 L Q+ L+ VH N+ ++ + D + A Sbjct: 199 LTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGD------VSALWKVGTRGPASS 252 Query: 534 WPVKWYAPECINYY--KFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERM 591 PV + E +N F+ + W G+ ++ + P+ G+ + ++ + Sbjct: 253 VPVTYAPREFLNASTATFTHALNAWQLGLSIYRVWCL-FLPF-GLVTPGIKGSWKRPS-L 309 Query: 592 GCP----------AGCPREMYDLMNLCWTYDVENR---------PGFAAVELRLRN 628 P P + L+ +D R P F ++ + + Sbjct: 310 RVPGTDSLAFGSCTPLPDFVKTLIGRFLNFDRRRRLLPLEAMETPEFLQLQNEISS 365 >5IXI-A nrPDB Length = 544 Score = 36.1 bits (82), Expect = 0.050, Method: Composition-based stats. Identities = 23/112 (20%), Positives = 45/112 (40%), Gaps = 14/112 (12%) Query: 17 FGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAH----------GRKAHHYTI 66 G I E A + L Q G +G+Y+LR S ++V ++ ++ I Sbjct: 423 HGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQI 482 Query: 67 ERELNGTYAIAGGRTHASPADLCHYHSQE---SDGLVCLLKKPF-NRPQGVQ 114 E + R+ S DL + ++ +D + +LK+ +P+ + Sbjct: 483 EVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREIS 534 Score = 30.7 bits (68), Expect = 1.7, Method: Composition-based stats. Identities = 21/106 (19%), Positives = 40/106 (37%), Gaps = 16/106 (15%) Query: 170 HGKISREESEQIVLIGSKTNGKFLIRARDNNGSYAL----CLLHEGKV-------LHYRI 218 HG I E + + G +++R + L C +V +++I Sbjct: 423 HGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQI 482 Query: 219 DKDKTGKLSIPEGKK-FDTLWQLVEHYSYK---ADGLLRVLTVPCQ 260 + K G+ S+ + F +L L+ H + D + +L CQ Sbjct: 483 EVQK-GRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQ 527 >6G5I-z nrPDB Length = 568 Score = 35.8 bits (81), Expect = 0.065, Method: Composition-based stats. Identities = 21/85 (24%), Positives = 38/85 (44%), Gaps = 4/85 (4%) Query: 443 SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYL-EESNFVHRDLAARNVL 501 S +LVM + L +N + + EL QV M+ + +++ VH DL+ N+L Sbjct: 272 SHVLVMSFIGKDDMPAPLLKNVQLSESKARELYLQVIQYMRRMYQDARLVHADLSEFNML 331 Query: 502 LVTQHYAKISDFGLSKALRADENYY 526 I D +S+++ D + Sbjct: 332 YHGGG-VYIID--VSQSVEHDHPHA 353 >4OTP-A nrPDB Length = 352 Score = 35.8 bits (81), Expect = 0.066, Method: Composition-based stats. Identities = 21/85 (24%), Positives = 38/85 (44%), Gaps = 4/85 (4%) Query: 443 SWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYL-EESNFVHRDLAARNVL 501 S +LVM + L +N + + EL QV M+ + +++ VH DL+ N+L Sbjct: 130 SHVLVMSFIGKDDMPAPLLKNVQLSESKARELYLQVIQYMRRMYQDARLVHADLSEFNML 189 Query: 502 LVTQHYAKISDFGLSKALRADENYY 526 I D +S+++ D + Sbjct: 190 YHGGG-VYIID--VSQSVEHDHPHA 211 >2XP1-A nrPDB Length = 178 Score = 34.6 bits (78), Expect = 0.13, Method: Composition-based stats. Identities = 15/72 (20%), Positives = 27/72 (37%), Gaps = 6/72 (8%) Query: 177 ESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVL-HYRIDKDKTGKLSIPEGKKFD 235 ESE + + FLIR +G L + V H +I++ K F+ Sbjct: 24 ESENYLRSSTD---DFLIRKGSRHGYCVLVIKFASDVFVHMKIEEHSE--HYTCSNKHFE 78 Query: 236 TLWQLVEHYSYK 247 + +++ Y Sbjct: 79 DIDEVISVYVRP 90 >3NNR-A nrPDB Length = 228 Score = 34.6 bits (78), Expect = 0.14, Method: Composition-based stats. Identities = 27/195 (13%), Positives = 58/195 (29%), Gaps = 49/195 (25%) Query: 434 RMIGICEAESWML--VM-EMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNF 490 + +S ++ + E +L + ++R + +++ + V G+ F Sbjct: 41 NLYYHFRNKSDIIYEIFQEYEKLVDYYLDIPEDRPITLEDMTFYLESVFDGLW---SYRF 97 Query: 491 VHRDLAARNVLLVTQHYA--------------------KISDFGLSKALRADENYYKAQT 530 HRDL LL + K++D G+ + D + Sbjct: 98 FHRDLE---YLLDSDPRLRQDYREFTNRCLAAINRIFAKLADAGIIQPQPEDLRSAMSLN 154 Query: 531 HGKWPVKWYA----------PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSE 580 W A P ++ + G+ ++ + + PY + E Sbjct: 155 VWLVITNWMAFLKTAHAAEEPASLSLTELKQ-------GI--YQVLTL-EVPYLTPEYRE 204 Query: 581 VTAMLEKGERMGCPA 595 L + R P Sbjct: 205 RVLALREKYRPTLPE 219 >4BVU-A nrPDB Length = 211 Score = 33.8 bits (76), Expect = 0.24, Method: Composition-based stats. Identities = 23/143 (16%), Positives = 46/143 (32%), Gaps = 26/143 (18%) Query: 372 LEDKELGSGNFGTVKKGYYQMKKVVKTVAV------KILKNEANDPALKDELL-AEANVM 424 + K +G G+ + + + K + +IL+ + L + EA+V Sbjct: 43 ILGKLIGQGSTAEIFEDVNDSSALYKKYDLIGNQYNEILEMAWQESELFNAFYGDEASV- 101 Query: 425 QQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKY 484 +++ G L M PL+ + D + + Sbjct: 102 -------VIQYGG-----DVYLRMLRVPGTPLSDI--DTADIPDNIESLYLQLICK---- 143 Query: 485 LEESNFVHRDLAARNVLLVTQHY 507 L E + +H DL N+L + Sbjct: 144 LNELSIIHYDLNTGNMLYDKESE 166 >5VKO-A nrPDB Length = 211 Score = 33.8 bits (76), Expect = 0.26, Method: Composition-based stats. Identities = 21/109 (19%), Positives = 44/109 (40%), Gaps = 13/109 (11%) Query: 154 LEKLIATTAHE--KMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSY-ALCLLHE 210 ++ A H P++ + ++E + SK G+F+IR + + + Sbjct: 2 IDPFTAKRTHRVINHPYYF-PFNGRQAED--YLRSKERGEFVIRQSSRGDDHLVITWKLD 58 Query: 211 GKV-LHYRIDKDKT------GKLSIPEGKKFDTLWQLVEHYSYKADGLL 252 + H I + + GK+ I + +K++ L Q++ Y LL Sbjct: 59 KDLFQHIDIQELEKENPLALGKVLIVDNQKYNDLDQIIVEYLQNKVRLL 107 >6FAI-l nrPDB Length = 425 Score = 33.4 bits (75), Expect = 0.26, Method: Composition-based stats. Identities = 13/96 (13%), Positives = 40/96 (41%), Gaps = 16/96 (16%) Query: 439 CEAESWMLVMEMAELGPLNKYLQQNRHVKD--KNIIELVHQVSMGMKYLEESNFVHRDLA 496 + ++VME+ E P+ + L++++++ +++ + ++ S +H D Sbjct: 180 FDNSRHIVVMELIEGYPMRR-LRKHKNIPKLYSDLMCFIVDLA-------NSGLIHCDFN 231 Query: 497 ARNVLLVT------QHYAKISDFGLSKALRADENYY 526 N+++ + DF +++ + Y Sbjct: 232 EFNIMIKDKLEDENDCGFVVIDFPQCISIQHQDADY 267 >3PJP-A nrPDB Length = 199 Score = 33.4 bits (75), Expect = 0.31, Method: Composition-based stats. Identities = 22/99 (22%), Positives = 43/99 (43%), Gaps = 11/99 (11%) Query: 166 MPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSY-ALCLLHEGKV-LHYRIDKDKT 223 P++ + +++E + SK G F+IR + A+ + + H I + + Sbjct: 10 HPYYF-PFNGKQAED--YLRSKERGDFVIRQSSRGDDHLAITWKLDKDLFQHVDIQELEK 66 Query: 224 ------GKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLT 256 GK+ + EG+++ L Q++ Y LL LT Sbjct: 67 ENPLALGKVLVVEGQRYHDLDQIIVEYLQNKIRLLNELT 105 >1Y3T-A nrPDB Length = 337 Score = 33.4 bits (75), Expect = 0.31, Method: Composition-based stats. Identities = 23/130 (17%), Positives = 44/130 (33%), Gaps = 18/130 (13%) Query: 20 ITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIA-- 77 +T ++ + +DG +++ S G + H +H L G + Sbjct: 199 LTGDQLHRIVAAQKNTDGQFIVVSSEGPKGDRIVDHYHE---YHTETFYCLEGQMTMWTD 255 Query: 78 -------GGRTHASPADLCH------YHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLK 124 G PA+ H ++++ LV L +PF R G + F Sbjct: 256 GQEIQLNPGDFLHVPANTVHSYRLDSHYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCKP 315 Query: 125 ENLIREYVKQ 134 + L + + Q Sbjct: 316 QALRFDRILQ 325 >4H05-A nrPDB Length = 273 Score = 32.7 bits (73), Expect = 0.51, Method: Composition-based stats. Identities = 15/57 (26%), Positives = 22/57 (38%), Gaps = 3/57 (5%) Query: 490 FVHRDLAARNVLLVTQ--HYAKISDFG-LSKALRADENYYKAQTHGKWPVKWYAPEC 543 H DL NVLL + + D G + +A R + + W+ PEC Sbjct: 186 VCHGDLCPDNVLLDPRTCEVTGLIDVGRVGRADRHSDLALVLRELAHEEDPWFGPEC 242 >1FMT-A nrPDB Length = 314 Score = 31.5 bits (70), Expect = 1.1, Method: Composition-based stats. Identities = 17/92 (18%), Positives = 30/92 (32%), Gaps = 6/92 (6%) Query: 77 AGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTW 136 G + A+L GL+ LK+ + + + E L +E + W Sbjct: 163 TSGTLYDKLAEL------GPQGLITTLKQLADGTAKPEVQDETLVTYAEKLSKEEARIDW 216 Query: 137 NLQGQALEQAIISQKPQLEKLIATTAHEKMPW 168 +L LE+ I + P + W Sbjct: 217 SLSAAQLERCIRAFNPWPMSWLEIEGQPVKVW 248 >2NVO-A nrPDB Length = 535 Score = 31.1 bits (69), Expect = 1.5, Method: Composition-based stats. Identities = 10/39 (25%), Positives = 18/39 (46%) Query: 42 RQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGR 80 RQ RN GGF +V+ + + + GT+ + + Sbjct: 25 RQVRNNAGGFVYTVSDESRLTRFLVLGVDGGTFYASAQK 63 >1FUI-A nrPDB Length = 591 Score = 31.1 bits (69), Expect = 1.5, Method: Composition-based stats. Identities = 16/61 (26%), Positives = 27/61 (44%), Gaps = 5/61 (8%) Query: 499 NVLLVTQHYAKISDFGLSKALRAD-ENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWS 557 N++ +I++ G S L D + +T+ WP W+AP F+ DV+S Sbjct: 464 NIIKGLGPVLQIAE-GWSVELPKDVHDILNKRTNSTWPTTWFAPRLTGKGPFT---DVYS 519 Query: 558 F 558 Sbjct: 520 V 520 >5XXU-a nrPDB Length = 112 Score = 31.1 bits (69), Expect = 1.6, Method: Composition-based stats. Identities = 11/46 (23%), Positives = 16/46 (34%), Gaps = 1/46 (2%) Query: 378 GSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANV 423 G G+ V + + K A+K A L EA+V Sbjct: 14 GRGHSAVV-RCSNCGRSCPKDKAIKRFNVRNIVDASSQRDLREASV 58 >3NPK-A nrPDB Length = 291 Score = 30.7 bits (68), Expect = 1.8, Method: Composition-based stats. Identities = 7/40 (17%), Positives = 19/40 (47%), Gaps = 4/40 (10%) Query: 456 LNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDL 495 L +Q N+ ++ V++ ++++ + +H DL Sbjct: 47 LLSVVQSNK----PELLNQALDVALALEFIHTYSLIHDDL 82 >1NW6-A nrPDB Length = 319 Score = 30.7 bits (68), Expect = 2.0, Method: Composition-based stats. Identities = 24/153 (15%), Positives = 48/153 (31%), Gaps = 19/153 (12%) Query: 130 EYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTN 189 + V++ ++ + +A P+ + + W +++ E++ K Sbjct: 173 DAVREPYDEETKAAYMKDKRLNPES---VEKGRNPTNVWRMSRLNGNSLERVGHPTQKPA 229 Query: 190 GKF--LIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSY- 246 L+RA + GS L V ++ + F E+Y Sbjct: 230 AVIERLVRALSHPGSTVLDFFAGSGVTARVAIQEGRNSICTDAAPVFK------EYYQKQ 283 Query: 247 ----KADGLLRVLTVPCQKIGTQGNVNFGGRPQ 275 + DGL+ +G NFG Q Sbjct: 284 LTFLQDDGLIDKAR---SYEIVEGAANFGAALQ 313 >1Y1U-A nrPDB Length = 585 Score = 30.4 bits (67), Expect = 2.2, Method: Composition-based stats. Identities = 12/43 (27%), Positives = 22/43 (51%), Gaps = 2/43 (4%) Query: 18 GNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 60 G + +++A D L+ DG +LLR S + +GG ++ Sbjct: 469 GFVNKQQAHDLLINK--PDGTFLLRFSDSEIGGITIAWKFDSP 509 >3GXW-A nrPDB Length = 103 Score = 30.4 bits (67), Expect = 2.6, Method: Composition-based stats. Identities = 20/95 (21%), Positives = 40/95 (42%), Gaps = 11/95 (11%) Query: 166 MPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSY-ALCLLHEGKV-LHYRIDK--- 220 P++ + +++E + SK G F+IR + A+ + + H I + Sbjct: 10 HPYYF-PFNGKQAED--YLRSKERGDFVIRQSSRGDDHLAITWKLDKDLFQHVDIQEMEK 66 Query: 221 ---DKTGKLSIPEGKKFDTLWQLVEHYSYKADGLL 252 GK+ + EG+++ L Q++ Y LL Sbjct: 67 ENPLAMGKVLVVEGQRYHDLDQIIVEYLQNKIRLL 101 >6EF6-A nrPDB Length = 354 Score = 30.0 bits (66), Expect = 3.0, Method: Composition-based stats. Identities = 8/28 (28%), Positives = 13/28 (46%), Gaps = 3/28 (10%) Query: 489 NFVHRDLAARNVLLVT---QHYAKISDF 513 +H DL N+L+ + Q + DF Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >3VTI-A nrPDB Length = 761 Score = 30.0 bits (66), Expect = 3.2, Method: Composition-based stats. Identities = 24/112 (21%), Positives = 37/112 (33%), Gaps = 9/112 (8%) Query: 341 LPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVA 400 PM + Y DP + R + +G G F K + K K VA Sbjct: 161 FPMCEKCSRE-YHDPHDRRFHAQPVACFDCGPSLSFVGEGCFDDEIKCVAKALKEGKIVA 219 Query: 401 VK-----ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLV 447 +K L A D L ++ P+ V M + E + + +V Sbjct: 220 IKGIGGFHLAVNALDDEAVATLRRRK---KRYGKPFAVMMRDVEEVKKYCIV 268 >2ZNM-A nrPDB Length = 195 Score = 28.8 bits (63), Expect = 7.0, Method: Composition-based stats. Identities = 22/76 (28%), Positives = 33/76 (43%), Gaps = 8/76 (10%) Query: 174 SREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKT----GKLSIP 229 +R + + L +GK L+RA D+ + A L + YRID T GK + Sbjct: 104 NRSVAGKWALSQKGFDGKKLMRAYDSPEAAAAALKMQKLTEQYRIDSTPTVIVGGKYRVI 163 Query: 230 EGKKFD----TLWQLV 241 FD T+ +LV Sbjct: 164 FNNGFDGGVHTIKELV 179 >1JE3-A nrPDB Length = 97 Score = 28.4 bits (62), Expect = 9.9, Method: Composition-based stats. Identities = 10/43 (23%), Positives = 20/43 (46%), Gaps = 1/43 (2%) Query: 563 WEAFSYGQK-PYRGMKGSEVTAMLEKGERMGCPAGCPREMYDL 604 + G+ PY + E L+KGE + + CP+ + ++ Sbjct: 28 YRLDMVGEPCPYPAVATLEAMPQLKKGEILEVVSDCPQSINNI 70 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.139 0.403 Lambda K H 0.267 0.0427 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 26,261,815 Number of Sequences: 36641 Number of extensions: 1131484 Number of successful extensions: 7262 Number of sequences better than 10.0: 566 Number of HSP's better than 10.0 without gapping: 907 Number of HSP's successfully gapped in prelim test: 155 Number of HSP's that attempted gapping in prelim test: 3063 Number of HSP's gapped (non-prelim): 1306 length of query: 635 length of database: 10,336,785 effective HSP length: 103 effective length of query: 532 effective length of database: 6,562,762 effective search space: 3491389384 effective search space used: 3491389384 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 62 (28.4 bits)