BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P43403 (619 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2OZO-A nrPDB 1261 0.0 4FL3-A nrPDB 694 0.0 1U59-A nrPDB 587 e-168 4XZ1-A nrPDB 538 e-153 5C26-A nrPDB 376 e-104 1A81-A nrPDB 318 4e-87 4XEY-B nrPDB 236 2e-62 2FO0-A nrPDB 233 1e-61 4EBW-A nrPDB 220 1e-57 2J0K-A nrPDB 219 4e-57 2H8H-A nrPDB 215 5e-56 6F3F-A nrPDB 213 2e-55 4P5Q-A nrPDB 210 1e-54 2R2P-A nrPDB 208 5e-54 4CSV-A nrPDB 208 6e-54 1JPA-A nrPDB 208 6e-54 5MJB-A nrPDB 206 3e-53 5L6P-A nrPDB 205 4e-53 3BBT-B nrPDB 205 6e-53 4PDO-A nrPDB 203 2e-52 3DKO-A nrPDB 202 3e-52 2Y6O-A nrPDB 202 4e-52 4H1J-A nrPDB 201 5e-52 2XYN-A nrPDB 201 9e-52 5GNK-A nrPDB 200 1e-51 6NPU-A nrPDB 200 2e-51 1AD5-A nrPDB 199 3e-51 2VWV-A nrPDB 199 4e-51 4E93-A nrPDB 199 4e-51 3LZB-A nrPDB 198 5e-51 3KUL-B nrPDB 198 5e-51 4XI2-A nrPDB 195 4e-50 4LRM-A nrPDB 193 2e-49 1K9A-A nrPDB 192 3e-49 3PP0-A nrPDB 191 6e-49 2PL0-A nrPDB 189 2e-48 1U54-B nrPDB 189 4e-48 4HZS-A nrPDB 188 5e-48 2HK5-A nrPDB 184 7e-47 4Y93-A nrPDB 183 2e-46 5U6B-A nrPDB 181 8e-46 2DQ7-X nrPDB 180 2e-45 6E4F-A nrPDB 179 2e-45 4XCU-A nrPDB 177 1e-44 3QUP-A nrPDB 176 2e-44 5U6C-A nrPDB 176 2e-44 3A4O-X nrPDB 176 2e-44 5WNO-A nrPDB 176 3e-44 5SYS-A nrPDB 176 3e-44 3SXS-A nrPDB 174 1e-43 1LUF-A nrPDB 172 3e-43 3QGY-A nrPDB 172 3e-43 5AMN-A nrPDB 172 3e-43 1BYG-A nrPDB 170 1e-42 5KMM-A nrPDB 170 2e-42 6DBN-A nrPDB 169 4e-42 5FM2-A nrPDB 168 6e-42 5HLW-A nrPDB 167 1e-41 3ZBF-A nrPDB 167 1e-41 4AT3-A nrPDB 167 1e-41 3I81-A nrPDB 167 2e-41 1FVR-A nrPDB 166 3e-41 5A46-A nrPDB 166 3e-41 3AOX-A nrPDB 165 6e-41 2PSQ-A nrPDB 165 7e-41 3V5Q-A nrPDB 163 2e-40 3C1X-A nrPDB 162 5e-40 5H2U-A nrPDB 162 5e-40 3ZZW-A nrPDB 161 8e-40 3LMG-A nrPDB 161 8e-40 3TT0-A nrPDB 160 1e-39 2W1I-A nrPDB 160 1e-39 3GQL-A nrPDB 160 2e-39 3IO7-A nrPDB 159 2e-39 4HVI-A nrPDB 159 3e-39 5EG3-A nrPDB 159 4e-39 4K33-A nrPDB 158 6e-39 3PLS-A nrPDB 158 6e-39 6FEX-A nrPDB 157 1e-38 4XLV-A nrPDB 156 3e-38 4E20-A nrPDB 155 4e-38 6BSD-A nrPDB 155 5e-38 4OLI-A nrPDB 155 5e-38 6GQK-A nrPDB 154 8e-38 6DBM-A nrPDB 154 1e-37 3KRL-A nrPDB 154 1e-37 3BEA-A nrPDB 154 1e-37 2OGV-A nrPDB 154 1e-37 6FER-A nrPDB 152 4e-37 4R7H-A nrPDB 152 4e-37 5X02-A nrPDB 152 5e-37 5GRN-A nrPDB 151 7e-37 4XUF-A nrPDB 151 7e-37 3G0E-A nrPDB 149 3e-36 3CJF-A nrPDB 149 3e-36 4UYA-A nrPDB 137 1e-32 3PPZ-A nrPDB 131 7e-31 3DTC-A nrPDB 131 8e-31 4UY9-A nrPDB 130 1e-30 3HNG-A nrPDB 124 2e-28 3VHK-A nrPDB 121 8e-28 4RT7-A nrPDB 120 2e-27 5VO2-A nrPDB 107 2e-23 6FDY-U nrPDB 105 6e-23 4F0G-A nrPDB 105 9e-23 5USZ-A nrPDB 103 3e-22 4YFF-A nrPDB 102 5e-22 5X5O-A nrPDB 102 6e-22 3OMV-A nrPDB 100 1e-21 5HVK-A nrPDB 100 2e-21 4GS6-A nrPDB 100 3e-21 2XIK-A nrPDB 99 7e-21 3COM-A nrPDB 98 1e-20 4QMW-A nrPDB 98 1e-20 5WNL-A nrPDB 97 2e-20 5AR8-A nrPDB 97 3e-20 4LG4-A nrPDB 96 3e-20 5HI2-A nrPDB 96 4e-20 4NEU-A nrPDB 96 4e-20 6AO5-A nrPDB 96 5e-20 3DFA-A nrPDB 93 3e-19 4FZF-B nrPDB 92 5e-19 3NCG-A nrPDB 92 8e-19 5HIE-A nrPDB 90 3e-18 4AN9-A nrPDB 89 5e-18 5KZ7-A nrPDB 89 5e-18 3DAK-A nrPDB 89 7e-18 4L00-A nrPDB 89 8e-18 2HAK-A nrPDB 89 8e-18 5D9K-A nrPDB 88 1e-17 2Z7Q-A nrPDB 88 1e-17 5ES1-A nrPDB 88 1e-17 5C01-A nrPDB 88 1e-17 2QNJ-A nrPDB 88 1e-17 6C9D-A nrPDB 87 2e-17 4WOV-A nrPDB 87 2e-17 3MA6-A nrPDB 87 2e-17 4MVF-A nrPDB 87 3e-17 6QAU-A nrPDB 87 3e-17 5JN2-A nrPDB 86 3e-17 5O0Y-A nrPDB 86 4e-17 4REW-A nrPDB 86 5e-17 5EZV-A nrPDB 86 5e-17 1S9I-A nrPDB 86 6e-17 3IS5-A nrPDB 86 7e-17 4CFH-A nrPDB 85 1e-16 4CFF-A nrPDB 85 1e-16 5DBX-A nrPDB 84 1e-16 4RA4-A nrPDB 84 1e-16 3Q5I-A nrPDB 84 1e-16 4RED-A nrPDB 84 2e-16 4WNO-A nrPDB 84 3e-16 2YAB-A nrPDB 83 4e-16 5KKR-C nrPDB 83 4e-16 2YZA-A nrPDB 82 7e-16 2J90-A nrPDB 82 8e-16 3LIJ-A nrPDB 82 8e-16 3EQC-A nrPDB 82 8e-16 6CTH-A nrPDB 82 9e-16 1FOT-A nrPDB 82 9e-16 3DXN-A nrPDB 82 9e-16 3GUB-A nrPDB 81 1e-15 3HZT-A nrPDB 81 1e-15 4TPT-A nrPDB 81 2e-15 5TQX-A nrPDB 80 3e-15 2A1A-B nrPDB 80 3e-15 6J5U-C nrPDB 80 3e-15 5XZW-A nrPDB 79 4e-15 5B2L-A nrPDB 79 4e-15 4YNZ-A nrPDB 79 5e-15 4JXF-A nrPDB 79 6e-15 4D2V-A nrPDB 79 6e-15 1ZWS-A nrPDB 79 7e-15 2A27-A nrPDB 79 8e-15 4L42-A nrPDB 78 1e-14 3QA8-A nrPDB 78 1e-14 4UZD-A nrPDB 78 1e-14 4RLP-A nrPDB 78 1e-14 5XD6-A nrPDB 78 1e-14 3UIU-A nrPDB 77 2e-14 2UV2-A nrPDB 77 2e-14 2X4F-A nrPDB 77 2e-14 4RGJ-A nrPDB 77 2e-14 2BPM-A nrPDB 77 2e-14 4FR4-A nrPDB 77 3e-14 6HXF-B nrPDB 76 3e-14 4KRC-A nrPDB 76 4e-14 6BDL-A nrPDB 76 5e-14 3D2K-A nrPDB 76 5e-14 5YKS-A nrPDB 75 6e-14 4M69-B nrPDB 75 7e-14 4PDS-A nrPDB 75 1e-13 3KK8-A nrPDB 75 1e-13 5F9E-A nrPDB 75 1e-13 3H4J-B nrPDB 74 1e-13 6E2O-A nrPDB 74 1e-13 2XNP-A nrPDB 74 1e-13 3PFQ-A nrPDB 74 1e-13 1VZO-A nrPDB 74 1e-13 5LPV-A nrPDB 74 2e-13 2I0E-A nrPDB 74 2e-13 2BDW-A nrPDB 74 2e-13 2YCR-A nrPDB 74 2e-13 4KIK-B nrPDB 74 2e-13 3ALO-A nrPDB 74 2e-13 4BTF-A nrPDB 74 3e-13 5LPZ-A nrPDB 74 3e-13 5TOS-A nrPDB 73 4e-13 3LM0-A nrPDB 73 5e-13 3MN3-A nrPDB 73 5e-13 4QTB-A nrPDB 72 5e-13 3I6U-A nrPDB 72 5e-13 3NIZ-A nrPDB 72 6e-13 4CQG-A nrPDB 72 7e-13 3A8W-A nrPDB 72 8e-13 4YZB-A nrPDB 71 1e-12 1U5R-A nrPDB 71 1e-12 3UTO-A nrPDB 71 1e-12 3TAC-A nrPDB 71 1e-12 3TXO-A nrPDB 71 2e-12 2GCD-A nrPDB 71 2e-12 1KOA-A nrPDB 70 2e-12 2V7O-A nrPDB 70 2e-12 4JLC-A nrPDB 70 2e-12 5JZN-A nrPDB 70 3e-12 6CCF-A nrPDB 70 3e-12 4M66-A nrPDB 70 3e-12 2QKW-B nrPDB 70 3e-12 6NT9-A nrPDB 70 3e-12 5FG8-A nrPDB 70 3e-12 4EUT-A nrPDB 70 3e-12 1UA2-A nrPDB 70 3e-12 5NGU-A nrPDB 70 3e-12 4EUU-A nrPDB 70 4e-12 3ORP-A nrPDB 70 4e-12 3UDB-A nrPDB 70 4e-12 2Y4I-B nrPDB 70 4e-12 4OW8-A nrPDB 69 5e-12 2BRG-A nrPDB 69 5e-12 3MIA-A nrPDB 69 6e-12 6O8B-A nrPDB 69 6e-12 6GU6-A nrPDB 69 6e-12 5DYK-A nrPDB 69 6e-12 4M7I-A nrPDB 69 6e-12 4X3F-A nrPDB 69 8e-12 4D28-A nrPDB 69 8e-12 4AGU-A nrPDB 68 1e-11 3KN6-A nrPDB 68 1e-11 3TKU-A nrPDB 68 1e-11 4AU8-A nrPDB 68 1e-11 4FG9-A nrPDB 68 1e-11 6B2Q-A nrPDB 68 1e-11 3ORZ-A nrPDB 68 1e-11 3ZDU-A nrPDB 68 1e-11 2WQN-A nrPDB 68 1e-11 5FET-A nrPDB 68 1e-11 2JDO-A nrPDB 67 2e-11 1KOB-A nrPDB 67 2e-11 4TNB-A nrPDB 67 2e-11 3VN9-A nrPDB 67 2e-11 5X3F-B nrPDB 67 2e-11 3NIE-A nrPDB 67 2e-11 5LOH-A nrPDB 67 2e-11 4OTD-A nrPDB 67 2e-11 4IDT-A nrPDB 67 2e-11 5EFQ-A nrPDB 67 2e-11 4AW2-A nrPDB 67 3e-11 5J5T-A nrPDB 67 3e-11 3MV5-A nrPDB 67 3e-11 6CMJ-A nrPDB 67 3e-11 5YV8-A nrPDB 66 4e-11 3N9X-A nrPDB 66 5e-11 3F3Z-A nrPDB 66 5e-11 3HDN-A nrPDB 66 5e-11 3UIM-A nrPDB 65 6e-11 4WB7-A nrPDB 65 6e-11 5KCV-A nrPDB 65 6e-11 5IG1-A nrPDB 65 6e-11 4B8L-A nrPDB 65 7e-11 4PL5-B nrPDB 65 7e-11 5N23-A nrPDB 65 8e-11 2VD5-A nrPDB 65 8e-11 4YHJ-A nrPDB 65 1e-10 4BBM-A nrPDB 65 1e-10 3NYO-A nrPDB 65 1e-10 1G3N-A nrPDB 65 1e-10 5WAX-A nrPDB 65 1e-10 3Q53-A nrPDB 64 1e-10 6FD3-A nrPDB 64 1e-10 5UIU-A nrPDB 64 2e-10 3FME-A nrPDB 64 2e-10 5G6V-A nrPDB 64 2e-10 4AF3-A nrPDB 64 2e-10 3UC3-A nrPDB 64 2e-10 4IC8-A nrPDB 64 2e-10 4APC-A nrPDB 64 2e-10 4EQM-A nrPDB 64 2e-10 3RP9-A nrPDB 64 2e-10 4KS7-A nrPDB 64 3e-10 6AMW-A nrPDB 63 3e-10 4ZSG-A nrPDB 63 3e-10 6DTL-A nrPDB 63 4e-10 6HV0-A nrPDB 63 4e-10 2OZA-A nrPDB 62 6e-10 3ZUT-A nrPDB 62 6e-10 2W96-B nrPDB 62 6e-10 2F57-A nrPDB 62 7e-10 1NY3-A nrPDB 62 7e-10 6BXI-A nrPDB 62 8e-10 4NIF-A nrPDB 62 8e-10 4JG6-A nrPDB 62 8e-10 1V0B-A nrPDB 62 8e-10 2W4O-A nrPDB 62 9e-10 2VN9-A nrPDB 62 9e-10 2ABL-A nrPDB 62 9e-10 4CRS-A nrPDB 62 1e-09 2I6L-A nrPDB 62 1e-09 6CQF-A nrPDB 62 1e-09 3GC9-A nrPDB 62 1e-09 3T04-A nrPDB 61 1e-09 3DLS-A nrPDB 61 1e-09 4NST-A nrPDB 61 1e-09 2WTK-C nrPDB 61 1e-09 5Z33-A nrPDB 61 1e-09 3PG1-A nrPDB 61 1e-09 3KA0-A nrPDB 61 2e-09 2Y7J-A nrPDB 61 2e-09 4MWI-A nrPDB 61 2e-09 2VZ6-A nrPDB 61 2e-09 3DB8-A nrPDB 60 2e-09 4CZT-A nrPDB 60 2e-09 5U6Y-A nrPDB 60 3e-09 2JC6-A nrPDB 60 3e-09 2BUJ-A nrPDB 60 4e-09 4FIE-A nrPDB 59 4e-09 3BHH-A nrPDB 59 5e-09 3SOA-A nrPDB 59 6e-09 4XBR-A nrPDB 59 6e-09 4BGQ-A nrPDB 59 6e-09 4JDH-A nrPDB 59 7e-09 4B6L-A nrPDB 59 7e-09 2Q0N-A nrPDB 59 8e-09 3GC0-A nrPDB 59 9e-09 5D7A-A nrPDB 58 9e-09 3OHT-A nrPDB 58 9e-09 5U06-A nrPDB 58 1e-08 4I6B-A nrPDB 58 1e-08 2JAM-A nrPDB 58 1e-08 4EWQ-A nrPDB 58 2e-08 3C51-A nrPDB 57 2e-08 4U41-A nrPDB 57 2e-08 2F9G-A nrPDB 57 3e-08 2AUG-A nrPDB 56 4e-08 2OU7-A nrPDB 56 4e-08 1CM8-A nrPDB 56 4e-08 4J52-A nrPDB 56 4e-08 6BFN-A nrPDB 55 6e-08 4PWN-A nrPDB 55 6e-08 4G3E-A nrPDB 55 8e-08 4LQP-A nrPDB 55 8e-08 3HKO-A nrPDB 55 9e-08 6ED6-A nrPDB 55 1e-07 1NRV-A nrPDB 54 1e-07 3FXW-A nrPDB 54 2e-07 6E9W-A nrPDB 54 2e-07 1JNK-A nrPDB 54 2e-07 5UUU-A nrPDB 54 2e-07 1TKI-A nrPDB 54 2e-07 5O2C-A nrPDB 54 3e-07 1PHK-A nrPDB 54 3e-07 2H34-A nrPDB 53 3e-07 5O2B-A nrPDB 53 3e-07 5AIR-A nrPDB 53 3e-07 5J0A-A nrPDB 53 3e-07 2PLE-A nrPDB 53 3e-07 3FI2-A nrPDB 53 3e-07 4C0T-A nrPDB 53 4e-07 3G2F-A nrPDB 53 4e-07 3PVW-A nrPDB 53 4e-07 2XS0-A nrPDB 53 5e-07 3QD2-B nrPDB 52 5e-07 4MYG-A nrPDB 52 6e-07 2RIO-A nrPDB 52 6e-07 4QNY-A nrPDB 52 6e-07 4O2Z-A nrPDB 52 8e-07 3OZ6-A nrPDB 52 1e-06 5AWM-A nrPDB 52 1e-06 4X7Q-B nrPDB 51 1e-06 1PY5-A nrPDB 51 1e-06 1GRI-A nrPDB 51 2e-06 4TN6-A nrPDB 51 2e-06 3E7O-A nrPDB 50 2e-06 3M42-A nrPDB 50 4e-06 3MDY-A nrPDB 49 4e-06 3REP-A nrPDB 49 5e-06 5TUR-A nrPDB 49 5e-06 2LCT-A nrPDB 49 6e-06 5FQD-C nrPDB 49 8e-06 2CRH-A nrPDB 49 8e-06 5L2Q-C nrPDB 48 1e-05 4Y83-A nrPDB 48 1e-05 3BGP-A nrPDB 47 2e-05 4H1O-A nrPDB 47 2e-05 4RC3-A nrPDB 47 3e-05 2HW6-A nrPDB 47 3e-05 2WTK-B nrPDB 46 4e-05 2PMN-X nrPDB 46 4e-05 1ZXE-A nrPDB 46 4e-05 2EOB-A nrPDB 46 5e-05 4E7W-A nrPDB 45 7e-05 4CRL-A nrPDB 45 7e-05 3SOC-A nrPDB 45 1e-04 2LQW-A nrPDB 44 1e-04 3Q4U-A nrPDB 44 2e-04 4C59-A nrPDB 44 2e-04 3SV0-A nrPDB 44 2e-04 3MY0-A nrPDB 44 3e-04 5VD3-A nrPDB 43 4e-04 3RAW-A nrPDB 42 6e-04 5UNP-A nrPDB 42 6e-04 5Y86-A nrPDB 42 6e-04 4IAN-A nrPDB 42 8e-04 5E8V-A nrPDB 42 0.001 2EKX-A nrPDB 41 0.001 4M4Z-A nrPDB 40 0.002 6CKI-A nrPDB 40 0.002 2WO6-A nrPDB 40 0.003 3E3P-A nrPDB 40 0.003 4NT4-A nrPDB 40 0.003 5TE0-A nrPDB 40 0.003 2QLU-A nrPDB 40 0.004 6O6Q-A nrPDB 40 0.004 2C47-A nrPDB 39 0.005 5VDK-A nrPDB 39 0.005 2CMW-A nrPDB 39 0.005 2CS0-A nrPDB 39 0.006 6GVJ-A nrPDB 39 0.007 6FYV-A nrPDB 39 0.008 3HMP-A nrPDB 38 0.010 2X7G-A nrPDB 38 0.012 6CMQ-A nrPDB 38 0.014 2ZMD-A nrPDB 38 0.016 3EB0-A nrPDB 37 0.018 2KK6-A nrPDB 37 0.019 1KA6-A nrPDB 37 0.020 1M27-A nrPDB 37 0.023 4XHL-A nrPDB 37 0.024 5AP3-A nrPDB 37 0.024 4XHH-A nrPDB 37 0.027 2EYZ-A nrPDB 37 0.027 5VC6-A nrPDB 37 0.033 5M6U-B nrPDB 36 0.042 5X8I-B nrPDB 36 0.044 2CHL-A nrPDB 36 0.049 5ZTN-A nrPDB 36 0.061 5M07-A nrPDB 35 0.065 5IKW-A nrPDB 35 0.068 2HDV-A nrPDB 35 0.10 6J6I-B nrPDB 35 0.11 6EWX-A nrPDB 35 0.12 4Y12-A nrPDB 35 0.14 5VE6-A nrPDB 35 0.14 4LFI-A nrPDB 34 0.15 2PZI-A nrPDB 34 0.16 1MIL-A nrPDB 33 0.25 4AZW-A nrPDB 33 0.32 5CLR-A nrPDB 33 0.50 1XA6-A nrPDB 33 0.54 5UV4-A nrPDB 32 0.55 4MD7-E nrPDB 32 0.74 4AZV-A nrPDB 32 0.81 3QWY-A nrPDB 32 0.86 3ZUS-A nrPDB 32 1.1 3ZUR-A nrPDB 31 1.3 3R11-A nrPDB 31 1.7 5XVU-A nrPDB 31 1.8 5OAT-A nrPDB 31 2.1 3K3Q-C nrPDB 31 2.1 2W2D-A nrPDB 30 2.1 6EII-A nrPDB 30 2.2 5WQK-A nrPDB 30 2.2 1E1H-B nrPDB 30 2.5 2VIF-A nrPDB 30 2.5 5X1R-A nrPDB 30 2.8 1RPY-A nrPDB 30 2.8 5UU1-A nrPDB 30 3.8 6HMD-A nrPDB 30 4.0 3CXL-A nrPDB 30 4.2 6GSK-4I nrPDB 29 6.1 3K4E-A nrPDB 29 7.4 2RSV-A nrPDB 28 8.2 1CSN-A nrPDB 28 8.3 2LAV-A nrPDB 28 8.7 3LLT-A nrPDB 28 9.7 >2OZO-A nrPDB Length = 613 Score = 1261 bits (3263), Expect = 0.0, Method: Compositional matrix adjust. Identities = 603/606 (99%), Positives = 606/606 (100%) Query: 1 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP 60 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP Sbjct: 1 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP 60 Query: 61 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD 120 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD Sbjct: 61 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD 120 Query: 121 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG 180 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG Sbjct: 121 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG 180 Query: 181 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK 240 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK Sbjct: 181 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK 240 Query: 241 LKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARIT 300 LKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARIT Sbjct: 241 LKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARIT 300 Query: 301 SPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMR 360 SPDKPRPMPMDTSV+ESP+SDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMR Sbjct: 301 SPDKPRPMPMDTSVFESPFSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMR 360 Query: 361 KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGG 420 KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGG Sbjct: 361 KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGG 420 Query: 421 PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDF 480 PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR+LAARNVLLVNRHYAKISDF Sbjct: 421 PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRNLAARNVLLVNRHYAKISDF 480 Query: 481 GLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY 540 GLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY Sbjct: 481 GLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY 540 Query: 541 KKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL 600 KKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL Sbjct: 541 KKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL 600 Query: 601 ASKVEG 606 ASKVEG Sbjct: 601 ASKVEG 606 >4FL3-A nrPDB Length = 635 Score = 694 bits (1790), Expect = 0.0, Method: Compositional matrix adjust. Identities = 340/631 (53%), Positives = 451/631 (71%), Gaps = 30/631 (4%) Query: 1 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP 60 M D A HLPFF+G+I+R EAE++L GM+DGL+LLRQ LGG+ LS+ H + HH+ Sbjct: 6 MADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYT 65 Query: 61 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD 120 IER+LNGTYAIAGG+ H PA+LC ++S++ DGL C L+KP NRP G++P+ G F+ L++ Sbjct: 66 IERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKE 125 Query: 121 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG 180 ++R+YV+QTW L+G+ALEQAIISQ PQ+EKLIATTAHE+MPW+H ++REE+E+ + G Sbjct: 126 NLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIG 185 Query: 181 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK 240 ++T+GKFL+R R G+YAL L++ V HY I +DK GK IPEG KFDTLWQLVE+ Sbjct: 186 SKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYS 245 Query: 241 LKADGLIYCLKEACPN-SSASNASGAAAPTLP-AHPSTLT-------------------- 278 KADGL+ L C + N + P LP +HP+T + Sbjct: 246 YKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRK 305 Query: 279 ----HPQRRIDTLNSDGYTPEPARITSPDKPR--PMPMDTSVYESPYSDPEELKDKKLFL 332 R+ T++ + Y PE A + P+ +PMDT V+ESP++DPEE++ K+++L Sbjct: 306 SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVFESPFADPEEIRPKEVYL 365 Query: 333 KRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QGTEKADTEEMMREAQIMH 391 R L + D ELG GNFG+V++G Y+M+K VA+K+LK + + A +E++ EA +M Sbjct: 366 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 425 Query: 392 QLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKY 451 QLDNPYIVR+IG+C+AE+ MLVMEMA GPL+K+L R + N+ EL+HQVSMGMKY Sbjct: 426 QLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKY 484 Query: 452 LEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI 511 LEE NFVHRDLAARNVLLV +HYAKISDFGLSKAL AD++YY A++ GKWP+KWYAPECI Sbjct: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 Query: 512 NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYAL 571 N+ KFSS+SDVWS+GV MWEA SYGQKPY+ MKG EV A +E+G+RM CP CP E+Y L Sbjct: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDL 604 Query: 572 MSDCWIYKWEDRPDFLTVEQRMRACYYSLAS 602 M+ CW Y E+RP F VE R+R YY + + Sbjct: 605 MNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 >1U59-A nrPDB Length = 287 Score = 587 bits (1512), Expect = e-168, Method: Compositional matrix adjust. Identities = 280/280 (100%), Positives = 280/280 (100%) Query: 327 DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMRE 386 DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMRE Sbjct: 1 DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMRE 60 Query: 387 AQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVS 446 AQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVS Sbjct: 61 AQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVS 120 Query: 447 MGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY 506 MGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY Sbjct: 121 MGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY 180 Query: 507 APECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPP 566 APECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPP Sbjct: 181 APECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPP 240 Query: 567 ELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEG 606 ELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEG Sbjct: 241 ELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEG 280 >4XZ1-A nrPDB Length = 262 Score = 538 bits (1387), Expect = e-153, Method: Compositional matrix adjust. Identities = 258/259 (99%), Positives = 258/259 (99%) Query: 1 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP 60 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP Sbjct: 4 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP 63 Query: 61 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD 120 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFD LRD Sbjct: 64 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDSLRD 123 Query: 121 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG 180 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG Sbjct: 124 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG 183 Query: 181 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK 240 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK Sbjct: 184 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK 243 Query: 241 LKADGLIYCLKEACPNSSA 259 LKADGLIYCLKEACPNSSA Sbjct: 244 LKADGLIYCLKEACPNSSA 262 >5C26-A nrPDB Length = 299 Score = 376 bits (966), Expect = e-104, Method: Compositional matrix adjust. Identities = 182/294 (61%), Positives = 230/294 (78%), Gaps = 2/294 (0%) Query: 310 MDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIK 369 MDT VYESPY+DPEE++ K+++L R L + D ELG GNFG+V++G Y+M+K VA+K Sbjct: 1 MDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVK 60 Query: 370 VLK-QGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVG 428 +LK + + A +E++ EA +M QLDNPYIVR+IG+C+AE+ MLVMEMA GPL+K+L Sbjct: 61 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQ 120 Query: 429 KREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGA 488 R + N+ EL+HQVSMGMKYLEE NFVHRDLAARNVLLV +HYAKISDFGLSKAL A Sbjct: 121 NRH-VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRA 179 Query: 489 DDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEV 548 D++YY A++ GKWP+KWYAPECIN+ KFSS+SDVWS+GV MWEA SYGQKPY+ MKG EV Sbjct: 180 DENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 239 Query: 549 MAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLAS 602 A +E+G+RM CP CP E+Y LM+ CW Y E+RP F VE R+R YY + + Sbjct: 240 TAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 293 >1A81-A nrPDB Length = 254 Score = 318 bits (815), Expect = 4e-87, Method: Compositional matrix adjust. Identities = 143/250 (57%), Positives = 192/250 (76%) Query: 5 AAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQ 64 A HLPFF+G+I+R EAE++L GM+DGL+LLRQ LGG+ LS+ H + HH+ IER+ Sbjct: 2 ANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERE 61 Query: 65 LNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAMVR 124 LNGTYAIAGG+ H PA+LC ++S++ DGL C L+KP NRP G++P+ G F+ L++ ++R Sbjct: 62 LNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIR 121 Query: 125 DYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQTD 184 +YV+QTW L+G+ALEQAIISQ PQ+EKLIATTAHE+MPW+H ++REE+E+ + G++T+ Sbjct: 122 EYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTN 181 Query: 185 GKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKAD 244 GKFL+R R G+YAL L++ V HY I +DK GK IPEG KFDTLWQLVE+ KAD Sbjct: 182 GKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKAD 241 Query: 245 GLIYCLKEAC 254 GL+ L C Sbjct: 242 GLLRVLTVPC 251 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 33/97 (34%), Positives = 52/97 (53%), Gaps = 1/97 (1%) Query: 8 LPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNG 67 +P+F+G ISR E+E+ + + +G FL+R + G Y L L+H+ + H+ I++ G Sbjct: 158 MPWFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHYRIDKDKTG 216 Query: 68 TYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNR 104 +I GK +L E YS DGL L PC + Sbjct: 217 KLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQK 253 >4XEY-B nrPDB Length = 408 Score = 236 bits (603), Expect = 2e-62, Method: Compositional matrix adjust. Identities = 152/464 (32%), Positives = 236/464 (50%), Gaps = 74/464 (15%) Query: 152 LIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYH 210 + + + E+ WYH ++R AE L SG +G FL+R + G ++SL Y VYH Sbjct: 1 MASVNSLEKHSWYHGPVSRNAAEYLLSSG--INGSFLVRESESSPGQRSISLRYEGRVYH 58 Query: 211 YLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTL 270 Y I+ GK + ++F+TL +LV + ADGLI Sbjct: 59 YRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLI----------------------- 95 Query: 271 PAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYE-SPYSDPEELKDKK 329 +TL +P +P + +P +VY SP D E++ Sbjct: 96 ----TTLHYP--------------------APKRNKP-----TVYGVSPNYDKWEMERTD 126 Query: 330 LFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQI 389 + +K +LG G +G V +GV++ K + VA+K LK+ T + EE ++EA + Sbjct: 127 ITMKH--------KLGGGQYGEVYEGVWK--KYSLTVAVKTLKEDT--MEVEEFLKEAAV 174 Query: 390 MHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVG-KREEIPVSNVAELLHQVSM 447 M ++ +P +V+L+GVC E ++ E G L +L R+E+ + + Q+S Sbjct: 175 MKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISS 234 Query: 448 GMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYA 507 M+YLE+KNF+HRDLAARN L+ H K++DFGLS+ + D YTA + K+P+KW A Sbjct: 235 AMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTA 292 Query: 508 PECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPE 567 PE + + KFS +SDVW++GV +WE +YG PY + +V +E+ RME P CP + Sbjct: 293 PESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEK 352 Query: 568 LYALMSDCWIYKWEDRPDFLTVEQRMRACYY--SLASKVEGPPG 609 +Y LM CW + DRP F + Q + S++ +VE G Sbjct: 353 VYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELG 396 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 32/107 (29%), Positives = 54/107 (50%), Gaps = 7/107 (6%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69 +++G +SR A E+L +G+ +G FL+R+ S G +SL ++ R +H+ I +G Sbjct: 12 WYHGPVSR-NAAEYLLSSGI-NGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKL 69 Query: 70 AIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPC---NRPS--GLEPQ 111 ++ AEL +S DGL L P N+P+ G+ P Sbjct: 70 YVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPN 116 >2FO0-A nrPDB Length = 495 Score = 233 bits (595), Expect = 1e-61, Method: Compositional matrix adjust. Identities = 151/457 (33%), Positives = 233/457 (50%), Gaps = 74/457 (16%) Query: 159 ERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYHYLISQDK 217 E+ WYH ++R AE L SG +G FL+R + G ++SL Y VYHY I+ Sbjct: 100 EKHSWYHGPVSRNAAEYLLSSG--INGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 157 Query: 218 AGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTL 277 GK + ++F+TL +LV + ADGLI +TL Sbjct: 158 DGKLYVSSESRFNTLAELVHHHSTVADGLI---------------------------TTL 190 Query: 278 THPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYE-SPYSDPEELKDKKLFLKRDN 336 +P +P + +P +VY SP D E++ + +K Sbjct: 191 HYP--------------------APKRNKP-----TVYGVSPNYDKWEMERTDITMKH-- 223 Query: 337 LLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNP 396 +LG G +G V +GV++ K + VA+K LK+ T + EE ++EA +M ++ +P Sbjct: 224 ------KLGGGQYGEVYEGVWK--KYSLTVAVKTLKEDT--MEVEEFLKEAAVMKEIKHP 273 Query: 397 YIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVG-KREEIPVSNVAELLHQVSMGMKYLEE 454 +V+L+GVC E ++ E G L +L R+E+ + + Q+S M+YLE+ Sbjct: 274 NLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEK 333 Query: 455 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR 514 KNF+HR+LAARN L+ H K++DFGLS+ + D YTA + K+P+KW APE + + Sbjct: 334 KNFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAPESLAYN 391 Query: 515 KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSD 574 KFS +SDVW++GV +WE +YG PY + +V +E+ RME P CP ++Y LM Sbjct: 392 KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRA 451 Query: 575 CWIYKWEDRPDFLTVEQRMRACYY--SLASKVEGPPG 609 CW + DRP F + Q + S++ +VE G Sbjct: 452 CWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELG 488 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 32/107 (29%), Positives = 54/107 (50%), Gaps = 7/107 (6%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69 +++G +SR A E+L +G+ +G FL+R+ S G +SL ++ R +H+ I +G Sbjct: 104 WYHGPVSR-NAAEYLLSSGI-NGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKL 161 Query: 70 AIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPC---NRPS--GLEPQ 111 ++ AEL +S DGL L P N+P+ G+ P Sbjct: 162 YVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPN 208 >4EBW-A nrPDB Length = 304 Score = 220 bits (560), Expect = 1e-57, Method: Compositional matrix adjust. Identities = 108/251 (43%), Positives = 157/251 (62%), Gaps = 3/251 (1%) Query: 344 LGCGNFGSVRQGVYRM-RKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 +G G FG V QG+Y + VAIK K T + E+ ++EA M Q D+P+IV+LI Sbjct: 46 IGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLI 105 Query: 403 GVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 GV + ++ME+ G L FL ++ + ++++ +Q+S + YLE K FVHRD+ Sbjct: 106 GVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDI 165 Query: 463 AARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDV 522 AARNVL+ + K+ DFGLS+ + +DS Y S GK P+KW APE INFR+F+S SDV Sbjct: 166 AARNVLVSSNDCVKLGDFGLSRYM--EDSTYYKASKGKLPIKWMAPESINFRRFTSASDV 223 Query: 523 WSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWED 582 W +GV MWE L +G KP++ +K +V+ IE G+R+ PP CPP LY+LM+ CW Y Sbjct: 224 WMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSR 283 Query: 583 RPDFLTVEQRM 593 RP F ++ ++ Sbjct: 284 RPRFTELKAQL 294 >2J0K-A nrPDB Length = 656 Score = 219 bits (557), Expect = 4e-57, Method: Compositional matrix adjust. Identities = 108/251 (43%), Positives = 156/251 (62%), Gaps = 3/251 (1%) Query: 344 LGCGNFGSVRQGVYRM-RKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 +G G FG V QG+Y + VAIK K T + E+ ++EA M Q D+P+IV+LI Sbjct: 398 IGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLI 457 Query: 403 GVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 GV + ++ME+ G L FL ++ + ++++ +Q+S + YLE K FVHRD+ Sbjct: 458 GVITENPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLSTALAYLESKRFVHRDI 517 Query: 463 AARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDV 522 AARNVL+ K+ DFGLS+ + +DS Y S GK P+KW APE INFR+F+S SDV Sbjct: 518 AARNVLVSATDCVKLGDFGLSRYM--EDSTYYKASKGKLPIKWMAPESINFRRFTSASDV 575 Query: 523 WSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWED 582 W +GV MWE L +G KP++ +K +V+ IE G+R+ PP CPP LY+LM+ CW Y Sbjct: 576 WMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSR 635 Query: 583 RPDFLTVEQRM 593 RP F ++ ++ Sbjct: 636 RPRFTELKAQL 646 >2H8H-A nrPDB Length = 535 Score = 215 bits (547), Expect = 5e-56, Method: Compositional matrix adjust. Identities = 140/431 (32%), Positives = 211/431 (48%), Gaps = 76/431 (17%) Query: 163 WYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSL-----IYGKTVYHYLISQD 216 WY +TR E+ER L + G FL+R + +G Y LS+ G V HY I + Sbjct: 150 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 209 Query: 217 KAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPST 276 +G + I T+F++L QLV Y ADGL + L CP S Sbjct: 210 DSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTS------------------- 250 Query: 277 LTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDN 336 KP+ + +E P R++ Sbjct: 251 ---------------------------KPQTQGLAKDAWEIP---------------RES 268 Query: 337 LLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNP 396 L + +++LG G FG V G + + VAIK LK GT E ++EAQ+M +L + Sbjct: 269 LRL-EVKLGQGCFGEVWMGTWNGTTR---VAIKTLKPGT--MSPEAFLQEAQVMKKLRHE 322 Query: 397 YIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREE-IPVSNVAELLHQVSMGMKYLEEK 455 +V+L V E + +V E G L FL G+ + + + + ++ Q++ GM Y+E Sbjct: 323 KLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 382 Query: 456 NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK 515 N+VHRDL A N+L+ K++DFGL++ + +D+ YTAR K+P+KW APE + + Sbjct: 383 NYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYGR 440 Query: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDC 575 F+ +SDVWS+G+ + E + G+ PY M EV+ +E+G RM CPPECP L+ LM C Sbjct: 441 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQC 500 Query: 576 WIYKWEDRPDF 586 W + E+RP F Sbjct: 501 WRKEPEERPTF 511 Score = 42.4 bits (98), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 27/98 (27%), Positives = 44/98 (44%), Gaps = 5/98 (5%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSL-----VHDVRFHHFPIERQ 64 +++G I+R E+E L A G FL+R+ + G Y LS+ + H+ I + Sbjct: 150 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 209 Query: 65 LNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPC 102 +G + I +L +YS+ DGL L C Sbjct: 210 DSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVC 247 >6F3F-A nrPDB Length = 455 Score = 213 bits (542), Expect = 2e-55, Method: Compositional matrix adjust. Identities = 140/431 (32%), Positives = 211/431 (48%), Gaps = 76/431 (17%) Query: 163 WYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSL-----IYGKTVYHYLISQD 216 WY +TR E+ER L + G FL+R + +G Y LS+ G V HY I + Sbjct: 70 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 129 Query: 217 KAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPST 276 +G + I T+F++L QLV Y ADGL + L CP S Sbjct: 130 DSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTS------------------- 170 Query: 277 LTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDN 336 KP+ + +E P R++ Sbjct: 171 ---------------------------KPQTQGLAKDAWEIP---------------RES 188 Query: 337 LLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNP 396 L + +++LG G FG V G + + VAIK LK GT E ++EAQ+M +L + Sbjct: 189 LRL-EVKLGQGCFGEVWMGTWNGTTR---VAIKTLKPGT--MSPEAFLQEAQVMKKLRHE 242 Query: 397 YIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREE-IPVSNVAELLHQVSMGMKYLEEK 455 +V+L V E + +V E G L FL G+ + + + + ++ Q++ GM Y+E Sbjct: 243 KLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERM 302 Query: 456 NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK 515 N+VHRDL A N+L+ K++DFGL++ + +D+ YTAR K+P+KW APE + + Sbjct: 303 NYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYGR 360 Query: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDC 575 F+ +SDVWS+G+ + E + G+ PY M EV+ +E+G RM CPPECP L+ LM C Sbjct: 361 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQC 420 Query: 576 WIYKWEDRPDF 586 W + E+RP F Sbjct: 421 WRKEPEERPTF 431 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 27/98 (27%), Positives = 44/98 (44%), Gaps = 5/98 (5%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSL-----VHDVRFHHFPIERQ 64 +++G I+R E+E L A G FL+R+ + G Y LS+ + H+ I + Sbjct: 70 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 129 Query: 65 LNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPC 102 +G + I +L +YS+ DGL L C Sbjct: 130 DSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVC 167 >4P5Q-A nrPDB Length = 361 Score = 210 bits (535), Expect = 1e-54, Method: Compositional matrix adjust. Identities = 116/282 (41%), Positives = 167/282 (59%), Gaps = 12/282 (4%) Query: 341 DIELGCGNFGSVRQGVYRM-RKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIV 399 D +G G FG V G ++ KK+I VAIK LK G + + + EA IM Q D+P I+ Sbjct: 38 DKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNII 97 Query: 400 RLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 RL GV +++ +M+V E G L FL + V + +L ++ GMKYL + +V Sbjct: 98 RLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYV 157 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKALGAD-DSYYTARSAGKWPLKWYAPECINFRKFS 517 HRDLAARN+L+ + K+SDFGLS+ L D ++ YT R GK P++W +PE I +RKF+ Sbjct: 158 HRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTR-GGKIPIRWTSPEAIAYRKFT 216 Query: 518 SRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWI 577 S SDVWSYG+ +WE +SYG++PY +M +V+ +++G R+ P +CP LY LM DCW Sbjct: 217 SASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQ 276 Query: 578 YKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKAEAACA 619 +RP F EQ S+ K+ PGS + +A A Sbjct: 277 KDRNNRPKF---EQ-----IVSILDKLIRNPGSLKIITSAAA 310 >2R2P-A nrPDB Length = 295 Score = 208 bits (530), Expect = 5e-54, Method: Compositional matrix adjust. Identities = 108/246 (43%), Positives = 152/246 (61%), Gaps = 4/246 (1%) Query: 344 LGCGNFGSVRQGVYRM-RKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 +G G FG V G ++ K+++ VAIK LK G + + + EA IM Q D+P I+ L Sbjct: 30 IGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLE 89 Query: 403 GVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 GV +++ +M+V E G L FL + V + +L +S GMKYL + +VHRD Sbjct: 90 GVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRD 149 Query: 462 LAARNVLLVNRHYAKISDFGLSKALGAD-DSYYTARSAGKWPLKWYAPECINFRKFSSRS 520 LAARN+L+ + K+SDFGLS+ L D ++ YT R GK P++W APE I FRKF+S S Sbjct: 150 LAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTR-GGKIPIRWTAPEAIAFRKFTSAS 208 Query: 521 DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKW 580 DVWSYG+ MWE +SYG++PY +M +V+ +E+G R+ P +CP LY LM DCW + Sbjct: 209 DVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKER 268 Query: 581 EDRPDF 586 RP F Sbjct: 269 NSRPKF 274 >4CSV-A nrPDB Length = 275 Score = 208 bits (529), Expect = 6e-54, Method: Compositional matrix adjust. Identities = 106/246 (43%), Positives = 155/246 (63%), Gaps = 8/246 (3%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 +LG G FG V +G + R I+VA+K LK+GT EE ++EAQIM +L +P +V+L Sbjct: 18 KLGSGQFGEVYEG--KWRNYNIEVAVKTLKEGT--MSVEEFLQEAQIMKKLKHPNLVQLY 73 Query: 403 GVCQAEA-LMLVMEMAGGGPLHKFLVG-KREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 GVC E + ++ E G L +L + + + ++ QV+ GM YLE +NF+HR Sbjct: 74 GVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAYLESQNFIHR 133 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRS 520 DLAARN L+ + K++DFGL++ + D+ YTAR+ K+P+KW APE I++ +FS +S Sbjct: 134 DLAARNCLVGENNVVKVADFGLARLINEDE--YTARAGAKFPIKWTAPEAISYNRFSIKS 191 Query: 521 DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKW 580 DVW++G+ +WE +YGQ PY M G EV+ +E+G RM P CP E+Y LM CW Sbjct: 192 DVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQGCPEEIYELMLQCWNKSP 251 Query: 581 EDRPDF 586 E+RP F Sbjct: 252 EERPTF 257 >1JPA-A nrPDB Length = 312 Score = 208 bits (529), Expect = 6e-54, Method: Compositional matrix adjust. Identities = 113/274 (41%), Positives = 159/274 (58%), Gaps = 8/274 (2%) Query: 319 YSDPEELKDKKLFLKRDNLLIADIE--LGCGNFGSVRQGVYRM-RKKQIDVAIKVLKQGT 375 + DP E + F K ++ IE +G G FG V G ++ K++I VAIK LK G Sbjct: 16 FEDPNEAV--REFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGY 73 Query: 376 EKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIP 434 + + + EA IM Q D+P ++ L GV ++ +M++ E G L FL + Sbjct: 74 TEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFT 133 Query: 435 VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD--DSY 492 V + +L ++ GMKYL + N+VHRDLAARN+L+ + K+SDFGLS+ L D D Sbjct: 134 VIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPT 193 Query: 493 YTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI 552 YT+ GK P++W APE I +RKF+S SDVWSYG+ MWE +SYG++PY M +V+ I Sbjct: 194 YTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI 253 Query: 553 EQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586 EQ R+ P +CP L+ LM DCW RP F Sbjct: 254 EQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKF 287 >5MJB-A nrPDB Length = 305 Score = 206 bits (524), Expect = 3e-53, Method: Compositional matrix adjust. Identities = 114/276 (41%), Positives = 160/276 (57%), Gaps = 8/276 (2%) Query: 320 SDPEELKDKKLFLKRDNLLIADIE--LGCGNFGSVRQGVYRM-RKKQIDVAIKVLKQGTE 376 SDP E + F K ++ IE +G G FG V +G ++ K++I VAIK LK G Sbjct: 10 SDPNEAV--REFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYS 67 Query: 377 KADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPV 435 + + + EA IM Q D+ I+RL GV ++ +M++ E L FL + V Sbjct: 68 EKQRRDFLSEASIMGQFDHRNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTV 127 Query: 436 SNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD--DSYY 493 + +L ++ GMKYL E N+VHRDLAARN+L+ + K+SDFGLS+ L D D Y Sbjct: 128 IQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTY 187 Query: 494 TARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIE 553 T+ GK P++W APE I +RKF+S SDVWSYG+ MWE +S+G++PY M +V+ IE Sbjct: 188 TSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIE 247 Query: 554 QGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTV 589 Q R+ P +CP L+ LM DCW RP F + Sbjct: 248 QDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEI 283 >5L6P-A nrPDB Length = 298 Score = 205 bits (522), Expect = 4e-53, Method: Compositional matrix adjust. Identities = 113/273 (41%), Positives = 160/273 (58%), Gaps = 8/273 (2%) Query: 320 SDPEELKDKKLFLKRDNLLIADIE--LGCGNFGSVRQGVYRM-RKKQIDVAIKVLKQGTE 376 SDP E + F K ++ IE +G G FG V +G + ++++ VAIK LK G Sbjct: 3 SDPNEAV--REFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYT 60 Query: 377 KADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPV 435 + + + EA IM Q D+P I+RL GV ++ +M++ E L FL + V Sbjct: 61 ERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTV 120 Query: 436 SNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD--DSYY 493 + +L ++ GMKYL E N+VHRDLAARN+L+ + K+SDFGLS+ L D D Y Sbjct: 121 IQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTY 180 Query: 494 TARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIE 553 T+ GK P++W APE I +RKF+S SDVWSYG+ MWE +SYG++PY M +V+ +E Sbjct: 181 TSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVE 240 Query: 554 QGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586 Q R+ P +CP L+ LM DCW+ RP F Sbjct: 241 QDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKF 273 >3BBT-B nrPDB Length = 328 Score = 205 bits (521), Expect = 6e-53, Method: Compositional matrix adjust. Identities = 102/245 (41%), Positives = 155/245 (63%), Gaps = 3/245 (1%) Query: 344 LGCGNFGSVRQGVY--RMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 LG G FG+V +G++ +I VAIK+L + T E M EA IM +D+P++VRL Sbjct: 23 LGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRL 82 Query: 402 IGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 +GVC + + LV ++ G L +++ ++ I + Q++ GM YLEE+ VHRD Sbjct: 83 LGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRD 142 Query: 462 LAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSD 521 LAARNVL+ + ++ KI+DFGL++ L D+ Y A GK P+KW A ECI++RKF+ +SD Sbjct: 143 LAARNVLVKSPNHVKITDFGLARLLEGDEKEYNA-DGGKMPIKWMALECIHYRKFTHQSD 201 Query: 522 VWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWE 581 VWSYGVT+WE +++G KPY + E+ +E+G+R+ PP C ++Y +M CW+ + Sbjct: 202 VWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDAD 261 Query: 582 DRPDF 586 RP F Sbjct: 262 SRPKF 266 >4PDO-A nrPDB Length = 299 Score = 203 bits (517), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 104/249 (41%), Positives = 148/249 (59%), Gaps = 3/249 (1%) Query: 344 LGCGNFGSVRQGVYRMR--KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 +G G FG V +G+ + KK++ VAIK LK G + + + EA IM Q + I+RL Sbjct: 42 IGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRL 101 Query: 402 IGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 GV + + +M++ E G L KFL K E V + +L ++ GMKYL N+VHR Sbjct: 102 EGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHR 161 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRS 520 DLAARN+L+ + K+SDFGLS+ L D S GK P++W APE I++RKF+S S Sbjct: 162 DLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSAS 221 Query: 521 DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKW 580 DVWS+G+ MWE ++YG++PY ++ EVM I G R+ P +CP +Y LM CW + Sbjct: 222 DVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQER 281 Query: 581 EDRPDFLTV 589 RP F + Sbjct: 282 ARRPKFADI 290 >3DKO-A nrPDB Length = 318 Score = 202 bits (515), Expect = 3e-52, Method: Compositional matrix adjust. Identities = 110/276 (39%), Positives = 158/276 (57%), Gaps = 8/276 (2%) Query: 319 YSDPEELKDKK----LFLKRDNLLIADIE--LGCGNFGSVRQGVYRM-RKKQIDVAIKVL 371 Y DPE +D F K + IE +G G FG V G ++ K+ + VAIK L Sbjct: 20 YIDPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTL 79 Query: 372 KQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKR 430 K G + + + EA IM Q D+P +V L GV + + +M+V+E G L FL Sbjct: 80 KVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHD 139 Query: 431 EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADD 490 + V + +L ++ GM+YL + +VHRDLAARN+L+ + K+SDFGLS+ + D Sbjct: 140 GQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDP 199 Query: 491 SYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMA 550 + GK P++W APE I +RKF+S SDVWSYG+ MWE +SYG++PY M +V+ Sbjct: 200 EAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIK 259 Query: 551 FIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586 IE+G R+ P +CP L+ LM DCW + +RP F Sbjct: 260 AIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKF 295 >2Y6O-A nrPDB Length = 291 Score = 202 bits (513), Expect = 4e-52, Method: Compositional matrix adjust. Identities = 106/246 (43%), Positives = 149/246 (60%), Gaps = 4/246 (1%) Query: 344 LGCGNFGSVRQGVYRM-RKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 +G G FG V G ++ K++I VAIK LK G + + EA IM Q D+P I+ L Sbjct: 22 IGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLE 81 Query: 403 GVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 GV + + +M++ E G L FL V + +L + GMKYL + ++VHRD Sbjct: 82 GVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRD 141 Query: 462 LAARNVLLVNRHYAKISDFGLSKALGAD-DSYYTARSAGKWPLKWYAPECINFRKFSSRS 520 LAARN+L+ + K+SDFG+S+ L D ++ YT R GK P++W APE I +RKF+S S Sbjct: 142 LAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTR-GGKIPIRWTAPEAIAYRKFTSAS 200 Query: 521 DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKW 580 DVWSYG+ MWE +SYG++PY M +V+ IE+G R+ P +CP L+ LM DCW + Sbjct: 201 DVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKER 260 Query: 581 EDRPDF 586 DRP F Sbjct: 261 SDRPKF 266 >4H1J-A nrPDB Length = 293 Score = 201 bits (512), Expect = 5e-52, Method: Compositional matrix adjust. Identities = 104/256 (40%), Positives = 158/256 (61%), Gaps = 4/256 (1%) Query: 332 LKRDNLLIADIELGCGNFGSVRQGVYRMRK-KQIDVAIKVLKQGTEKADTEEMMREAQIM 390 + R+++++ I LG G FG V +GVY K ++I+VA+K K+ + E+ M EA IM Sbjct: 21 IAREDVVLNRI-LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIM 79 Query: 391 HQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMK 450 LD+P+IV+LIG+ + E ++ME+ G L +L + + V + Q+ M Sbjct: 80 KNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMA 139 Query: 451 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510 YLE N VHRD+A RN+L+ + K+ DFGLS+ + D+ YY A S + P+KW +PE Sbjct: 140 YLESINCVHRDIAVRNILVASPECVKLGDFGLSRYI-EDEDYYKA-SVTRLPIKWMSPES 197 Query: 511 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYA 570 INFR+F++ SDVW + V MWE LS+G++P+ ++ +V+ +E+G R+ P CPP LY Sbjct: 198 INFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYT 257 Query: 571 LMSDCWIYKWEDRPDF 586 LM+ CW Y DRP F Sbjct: 258 LMTRCWDYDPSDRPRF 273 >2XYN-A nrPDB Length = 292 Score = 201 bits (511), Expect = 9e-52, Method: Compositional matrix adjust. Identities = 104/258 (40%), Positives = 154/258 (59%), Gaps = 8/258 (3%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 +LG G +G V GV++ K + VA+K LK+ T + EE ++EA +M ++ +P +V+L+ Sbjct: 39 KLGGGQYGEVYVGVWK--KYSLTVAVKTLKEDT--MEVEEFLKEAAVMKEIKHPNLVQLL 94 Query: 403 GVCQAEA-LMLVMEMAGGGPLHKFLVG-KREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 GVC E +V E G L +L REE+ + + Q+S M+YLE+KNF+HR Sbjct: 95 GVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHR 154 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRS 520 DLAARN L+ H K++DFGLS+ + D YTA + K+P+KW APE + + FS +S Sbjct: 155 DLAARNCLVGENHVVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAPESLAYNTFSIKS 212 Query: 521 DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKW 580 DVW++GV +WE +YG PY + +V +E+G RME P CPP++Y LM CW + Sbjct: 213 DVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSP 272 Query: 581 EDRPDFLTVEQRMRACYY 598 DRP F Q ++ Sbjct: 273 ADRPSFAETHQAFETMFH 290 >5GNK-A nrPDB Length = 297 Score = 200 bits (509), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 98/245 (40%), Positives = 153/245 (62%), Gaps = 3/245 (1%) Query: 344 LGCGNFGSVRQGVY--RMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 LG G FG+V +G++ K +I VAIK L++ T +E++ EA +M +DNP++ RL Sbjct: 27 LGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRL 86 Query: 402 IGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 +G+C + L+M++ G L ++ ++ I + Q++ GM YLE++ VHRD Sbjct: 87 LGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRD 146 Query: 462 LAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSD 521 LAARNVL+ + KI+DFGL+K LGA++ Y A GK P+KW A E I R ++ +SD Sbjct: 147 LAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHA-EGGKVPIKWMALESILHRIYTHQSD 205 Query: 522 VWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWE 581 VWSYGVT+WE +++G KPY + E+ + +E+G+R+ PP C ++Y +M CW+ + Sbjct: 206 VWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDAD 265 Query: 582 DRPDF 586 RP F Sbjct: 266 SRPKF 270 >6NPU-A nrPDB Length = 298 Score = 200 bits (508), Expect = 2e-51, Method: Compositional matrix adjust. Identities = 110/297 (37%), Positives = 170/297 (57%), Gaps = 18/297 (6%) Query: 317 SPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE 376 SP D E++ + +K +LG G +G V +GV++ K + VA+K LK+ T Sbjct: 15 SPNYDKWEMERTDITMKH--------KLGGGQYGEVYEGVWK--KYSLTVAVKTLKEDT- 63 Query: 377 KADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVG-KREEIP 434 + EE ++EA +M ++ +P +V+L+GVC E ++ E G L +L R+E+ Sbjct: 64 -MEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVN 122 Query: 435 VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYT 494 + + Q+S M+YLE+KNF+HRDLAARN L+ H K++DFGLS+ + D YT Sbjct: 123 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDT--YT 180 Query: 495 ARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 554 A + K+P+KW APE + + KFS +SDVW++GV +WE +YG PY + +V +E+ Sbjct: 181 AHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEK 240 Query: 555 GKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYY--SLASKVEGPPG 609 RME P CP ++Y LM CW + DRP F + Q + S++ +VE G Sbjct: 241 DYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELG 297 >1AD5-A nrPDB Length = 438 Score = 199 bits (506), Expect = 3e-51, Method: Compositional matrix adjust. Identities = 140/454 (30%), Positives = 213/454 (46%), Gaps = 89/454 (19%) Query: 163 WYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSLI-----YGKTVYHYLI-SQ 215 W+ ++R++AER+L + G F++R + +G+Y+LS+ G TV HY I + Sbjct: 66 WFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTL 125 Query: 216 DKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPS 275 D G Y P T F TL +LV++ K DGL C K + P S+ Sbjct: 126 DNGGFYISPRST-FSTLQELVDHYKKGNDGL--CQKLSVPCMSSK--------------- 167 Query: 276 TLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRD 335 PQ+ P + +E P E LK +K Sbjct: 168 ----PQK--------------------------PWEKDAWEIPR---ESLKLEK------ 188 Query: 336 NLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN 395 +LG G FG V Y K VA+K +K G+ E + EA +M L + Sbjct: 189 -------KLGAGQFGEVWMATY---NKHTKVAVKTMKPGS--MSVEAFLAEANVMKTLQH 236 Query: 396 PYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKR-EEIPVSNVAELLHQVSMGMKYLEE 454 +V+L V E + ++ E G L FL + P+ + + Q++ GM ++E+ Sbjct: 237 DKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQ 296 Query: 455 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR 514 +N++HRDL A N+L+ KI+DFGL AR K+P+KW APE INF Sbjct: 297 RNYIHRDLRAANILVSASLVCKIADFGL------------ARVGAKFPIKWTAPEAINFG 344 Query: 515 KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSD 574 F+ +SDVWS+G+ + E ++YG+ PY M PEV+ +E+G RM P CP ELY +M Sbjct: 345 SFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMR 404 Query: 575 CWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPP 608 CW + E+RP F ++ + Y + S+ + P Sbjct: 405 CWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP 438 Score = 45.4 bits (106), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 31/98 (31%), Positives = 44/98 (44%), Gaps = 5/98 (5%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLV-HDVR----FHHFPIERQ 64 +F+ ISR +AE L G G F++R + G Y LS+ +D R H+ I Sbjct: 66 WFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTL 125 Query: 65 LNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPC 102 NG + I+ EL + Y + DGL L PC Sbjct: 126 DNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPC 163 >2VWV-A nrPDB Length = 302 Score = 199 bits (505), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 112/272 (41%), Positives = 156/272 (57%), Gaps = 8/272 (2%) Query: 321 DPEELKDKKLFLKRDNLLIADIE--LGCGNFGSVRQGVYRM-RKKQIDVAIKVLKQGTEK 377 DP E + F K ++ IE +G G FG V +G + KK+ VAIK LK G + Sbjct: 1 DPNEAV--REFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTE 58 Query: 378 ADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPVS 436 E + EA IM Q ++P I+RL GV + +M++ E G L FL + V Sbjct: 59 RQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVI 118 Query: 437 NVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKAL--GADDSYYT 494 + +L ++ GM+YL E ++VHRDLAARN+L+ + K+SDFGLS+ L + D T Sbjct: 119 QLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTET 178 Query: 495 ARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 554 + GK P++W APE I FRKF+S SD WSYG+ MWE +S+G++PY M +V+ IEQ Sbjct: 179 SSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQ 238 Query: 555 GKRMECPPECPPELYALMSDCWIYKWEDRPDF 586 R+ PP+CP L+ LM DCW RP F Sbjct: 239 DYRLPPPPDCPTSLHQLMLDCWQKDRNARPRF 270 >4E93-A nrPDB Length = 377 Score = 199 bits (505), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 101/268 (37%), Positives = 158/268 (58%), Gaps = 5/268 (1%) Query: 329 KLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQ 388 K L ++L++ + ++G GNFG V G R+R VA+K ++ + ++EA+ Sbjct: 108 KWVLNHEDLVLGE-QIGRGNFGEVFSG--RLRADNTLVAVKSCRETLPPDLKAKFLQEAR 164 Query: 389 IMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSM 447 I+ Q +P IVRLIGVC Q + + +VME+ GG FL + + V + +++ + Sbjct: 165 ILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAA 224 Query: 448 GMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYA 507 GM+YLE K +HRDLAARN L+ ++ KISDFG+S+ AD Y + + P+KW A Sbjct: 225 GMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSRE-EADGVYAASGGLRQVPVKWTA 283 Query: 508 PECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPE 567 PE +N+ ++SS SDVWS+G+ +WE S G PY + + F+E+G R+ CP CP Sbjct: 284 PEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDA 343 Query: 568 LYALMSDCWIYKWEDRPDFLTVEQRMRA 595 ++ LM CW Y+ RP F T+ Q +++ Sbjct: 344 VFRLMEQCWAYEPGQRPSFSTIYQELQS 371 Score = 35.0 bits (79), Expect = 0.098, Method: Compositional matrix adjust. Identities = 28/96 (29%), Positives = 49/96 (51%), Gaps = 11/96 (11%) Query: 144 SQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLI 203 S P+V+K + HE++ WYH ++ R E L G FL+R + + Y LS++ Sbjct: 1 SMIPEVQKPL----HEQL-WYHGAIPRAEVAELLVH----SGDFLVRESQGKQEYVLSVL 51 Query: 204 YGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYL 239 + H++I Q Y + EG F ++ L+++L Sbjct: 52 WDGLPRHFII-QSLDNLYRL-EGEGFPSIPLLIDHL 85 >3LZB-A nrPDB Length = 327 Score = 198 bits (504), Expect = 5e-51, Method: Compositional matrix adjust. Identities = 97/245 (39%), Positives = 152/245 (62%), Gaps = 3/245 (1%) Query: 344 LGCGNFGSVRQGVY--RMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 LG G FG+V +G++ K +I VAIK L++ T +E++ EA +M +DNP++ RL Sbjct: 23 LGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRL 82 Query: 402 IGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 +G+C + L+ ++ G L ++ ++ I + Q++ GM YLE++ VHRD Sbjct: 83 LGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRD 142 Query: 462 LAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSD 521 LAARNVL+ + KI+DFGL+K LGA++ Y A GK P+KW A E I R ++ +SD Sbjct: 143 LAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHA-EGGKVPIKWMALESILHRIYTHQSD 201 Query: 522 VWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWE 581 VWSYGVT+WE +++G KPY + E+ + +E+G+R+ PP C ++Y +M CW+ + Sbjct: 202 VWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDAD 261 Query: 582 DRPDF 586 RP F Sbjct: 262 SRPKF 266 >3KUL-B nrPDB Length = 325 Score = 198 bits (504), Expect = 5e-51, Method: Compositional matrix adjust. Identities = 113/277 (40%), Positives = 156/277 (56%), Gaps = 6/277 (2%) Query: 315 YESPYSDPEELKDKKLFLKRDNLLIADIE--LGCGNFGSVRQGVYRM-RKKQIDVAIKVL 371 Y P++ E + + F + IE +G G+ G V G R+ ++ + VAIK L Sbjct: 26 YAEPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKAL 85 Query: 372 KQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEAL-MLVMEMAGGGPLHKFLVGKR 430 K G + + + EA IM Q D+P I+RL GV L M+V E G L FL Sbjct: 86 KAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHD 145 Query: 431 EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD- 489 + + + +L V GM+YL + +VHRDLAARNVL+ + K+SDFGLS+ L D Sbjct: 146 GQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDP 205 Query: 490 DSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVM 549 D+ YT + GK P++W APE I FR FSS SDVWS+GV MWE L+YG++PY M +V+ Sbjct: 206 DAAYTT-TGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVI 264 Query: 550 AFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586 + +E+G R+ P CP L+ LM DCW RP F Sbjct: 265 SSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRF 301 >4XI2-A nrPDB Length = 446 Score = 195 bits (496), Expect = 4e-50, Method: Compositional matrix adjust. Identities = 134/440 (30%), Positives = 208/440 (47%), Gaps = 74/440 (16%) Query: 154 ATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKT------ 207 A + E WY +TR +AE+ L + +G F++R + G Y +S+ T Sbjct: 59 AEDSIEMYEWYSKHMTRSQAEQLLKQEGK-EGGFIVRDSSKAGKYTVSVFAKSTGEPQGV 117 Query: 208 VYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAA 267 + HY++ +Y + E F T+ +L+ Y + + GLI Sbjct: 118 IRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLI-------------------- 157 Query: 268 PTLPAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKD 327 S L +P ++ +K P Y S DP++L Sbjct: 158 -------SRLKYP------------------VSKQNKNAPSTAGLG-YGSWEIDPKDLT- 190 Query: 328 KKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREA 387 FLK ELG G FG V+ G +R Q DVAIK++++G+ D E + EA Sbjct: 191 ---FLK---------ELGTGQFGVVKYGKWR---GQYDVAIKMIREGSMSED--EFIEEA 233 Query: 388 QIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVS 446 ++M L + +V+L GVC + + ++ E G L +L R + E+ V Sbjct: 234 KVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVC 293 Query: 447 MGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY 506 M+YLE K F+HRDLAARN L+ ++ K+SDFGLS+ + D+ YT+ K+P++W Sbjct: 294 EAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDE--YTSSVGSKFPVRWS 351 Query: 507 APECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPP 566 PE + + KFSS+SD+W++GV MWE S G+ PY++ E I QG R+ P Sbjct: 352 PPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASE 411 Query: 567 ELYALMSDCWIYKWEDRPDF 586 +Y +M CW K ++RP F Sbjct: 412 RVYTIMYSCWHEKADERPSF 431 >4LRM-A nrPDB Length = 334 Score = 193 bits (491), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 97/248 (39%), Positives = 152/248 (61%), Gaps = 6/248 (2%) Query: 344 LGCGNFGSVRQGVY--RMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNP---YI 398 LG G FG+V +G++ K +I VAIK L++ T +E++ EA +M +DNP ++ Sbjct: 27 LGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPGNPHV 86 Query: 399 VRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 RL+G+C + L+ ++ G L ++ ++ I + Q++ GM YLE++ V Sbjct: 87 CRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLV 146 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 HRDLAARNVL+ + KI+DFGL+K LGA++ Y A GK P+KW A E I R ++ Sbjct: 147 HRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAE-GGKVPIKWMALESILHRIYTH 205 Query: 519 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIY 578 +SDVWSYGVT+WE +++G KPY + E+ + +E+G+R+ PP C ++Y +M CW+ Sbjct: 206 QSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMI 265 Query: 579 KWEDRPDF 586 + RP F Sbjct: 266 DADSRPKF 273 >1K9A-A nrPDB Length = 450 Score = 192 bits (489), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 144/448 (32%), Positives = 207/448 (46%), Gaps = 80/448 (17%) Query: 150 EKLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTV 208 E + A T MPW+H +TRE+AER LY G FL+R G Y L + V Sbjct: 69 EGVKAGTKLSLMPWFHGKITREQAERLLYP--PETGLFLVRESTNYPGDYTLCVSCEGKV 126 Query: 209 YHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAP 268 HY I A K I E F+ L QLVE+ Sbjct: 127 EHYRIMY-HASKLSIDEEVYFENLMQLVEHY----------------------------- 156 Query: 269 TLPAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDK 328 T ++DG T KP+ M + + Y L K Sbjct: 157 -----------------TTDADGLC------TRLIKPKVMEGTVAAQDEFYRSGWALNMK 193 Query: 329 KLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQ 388 +L L + +G G FG V G YR K VA+K +K A + + EA Sbjct: 194 ELKLLQ--------TIGKGEFGDVMLGDYRGNK----VAVKCIKN---DATAQAFLAEAS 238 Query: 389 IMHQLDNPYIVRLIGVCQAE--ALMLVMEMAGGGPLHKFLVGK-REEIPVSNVAELLHQV 445 +M QL + +V+L+GV E L +V E G L +L + R + + + V Sbjct: 239 VMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298 Query: 446 SMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKW 505 M+YLE NFVHRDLAARNVL+ + AK+SDFGL+K + + GK P+KW Sbjct: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS------STQDTGKLPVKW 352 Query: 506 YAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP 565 APE + +KFS++SDVWS+G+ +WE S+G+ PY ++ +V+ +E+G +M+ P CP Sbjct: 353 TAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP 412 Query: 566 PELYALMSDCWIYKWEDRPDFLTVEQRM 593 P +Y +M +CW RP FL + +++ Sbjct: 413 PAVYDVMKNCWHLDAATRPTFLQLREQL 440 Score = 38.5 bits (88), Expect = 0.009, Method: Compositional matrix adjust. Identities = 29/94 (30%), Positives = 44/94 (46%), Gaps = 3/94 (3%) Query: 8 LPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNG 67 +P+F+G I+R +AE L GLFL+R+ G Y L + + + H+ I + Sbjct: 80 MPWFHGKITREQAERLLYPP--ETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHAS- 136 Query: 68 TYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKP 101 +I +L E Y+ D DGL L KP Sbjct: 137 KLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKP 170 >3PP0-A nrPDB Length = 338 Score = 191 bits (486), Expect = 6e-49, Method: Compositional matrix adjust. Identities = 97/245 (39%), Positives = 150/245 (61%), Gaps = 3/245 (1%) Query: 344 LGCGNFGSVRQGVY--RMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 LG G FG+V +G++ +I VAIKVL++ T +E++ EA +M + +PY+ RL Sbjct: 25 LGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRL 84 Query: 402 IGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 +G+C + LV ++ G L + R + ++ Q++ GM YLE+ VHRD Sbjct: 85 LGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRD 144 Query: 462 LAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSD 521 LAARNVL+ + ++ KI+DFGL++ L D++ Y A GK P+KW A E I R+F+ +SD Sbjct: 145 LAARNVLVKSPNHVKITDFGLARLLDIDETEYHA-DGGKVPIKWMALESILRRRFTHQSD 203 Query: 522 VWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWE 581 VWSYGVT+WE +++G KPY + E+ +E+G+R+ PP C ++Y +M CW+ E Sbjct: 204 VWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSE 263 Query: 582 DRPDF 586 RP F Sbjct: 264 CRPRF 268 >2PL0-A nrPDB Length = 289 Score = 189 bits (481), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 99/244 (40%), Positives = 147/244 (60%), Gaps = 8/244 (3%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LG G FG V G Y K VA+K LKQG+ D + EA +M QL + +VRL Sbjct: 31 LGAGQFGEVWMGYYNGHTK---VAVKSLKQGSMSPDA--FLAEANLMKQLQHQRLVRLYA 85 Query: 404 VCQAEALMLVMEMAGGGPLHKFL-VGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 V E + ++ E G L FL ++ ++ + ++ Q++ GM ++EE+N++HRDL Sbjct: 86 VVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDL 145 Query: 463 AARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDV 522 A N+L+ + KI+DFGL++ + +D+ YTAR K+P+KW APE IN+ F+ +SDV Sbjct: 146 RAANILVSDTLSCKIADFGLARLI--EDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDV 203 Query: 523 WSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWED 582 WS+G+ + E +++G+ PY M PEV+ +E+G RM P CP ELY LM CW + ED Sbjct: 204 WSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPED 263 Query: 583 RPDF 586 RP F Sbjct: 264 RPTF 267 >1U54-B nrPDB Length = 291 Score = 189 bits (479), Expect = 4e-48, Method: Compositional matrix adjust. Identities = 98/251 (39%), Positives = 147/251 (58%), Gaps = 4/251 (1%) Query: 343 ELGCGNFGSVRQGVYRM-RKKQIDVAIKVLKQG--TEKADTEEMMREAQIMHQLDNPYIV 399 +LG G+FG VR+G + K + VA+K LK ++ ++ +RE MH LD+ ++ Sbjct: 25 KLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLI 84 Query: 400 RLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 RL GV + +V E+A G L L + + ++ QV+ GM YLE K F+H Sbjct: 85 RLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIH 144 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 519 RDLAARN+LL R KI DFGL +AL +D +Y + K P W APE + R FS Sbjct: 145 RDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHA 204 Query: 520 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIE-QGKRMECPPECPPELYALMSDCWIY 578 SD W +GVT+WE +YGQ+P+ + G +++ I+ +G+R+ P +CP ++Y +M CW + Sbjct: 205 SDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAH 264 Query: 579 KWEDRPDFLTV 589 K EDRP F+ + Sbjct: 265 KPEDRPTFVAL 275 >4HZS-A nrPDB Length = 341 Score = 188 bits (478), Expect = 5e-48, Method: Compositional matrix adjust. Identities = 98/251 (39%), Positives = 147/251 (58%), Gaps = 4/251 (1%) Query: 343 ELGCGNFGSVRQGVYRM-RKKQIDVAIKVLKQG--TEKADTEEMMREAQIMHQLDNPYIV 399 +LG G+FG VR+G + K + VA+K LK ++ ++ +RE MH LD+ ++ Sbjct: 19 KLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLI 78 Query: 400 RLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 RL GV + +V E+A G L L + + ++ QV+ GM YLE K F+H Sbjct: 79 RLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIH 138 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 519 RDLAARN+LL R KI DFGL +AL +D +Y + K P W APE + R FS Sbjct: 139 RDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHA 198 Query: 520 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIE-QGKRMECPPECPPELYALMSDCWIY 578 SD W +GVT+WE +YGQ+P+ + G +++ I+ +G+R+ P +CP ++Y +M CW + Sbjct: 199 SDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAH 258 Query: 579 KWEDRPDFLTV 589 K EDRP F+ + Sbjct: 259 KPEDRPTFVAL 269 >2HK5-A nrPDB Length = 270 Score = 184 bits (468), Expect = 7e-47, Method: Compositional matrix adjust. Identities = 94/245 (38%), Positives = 142/245 (57%), Gaps = 8/245 (3%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 +LG G FG V Y K VA+K +K G+ E + EA +M L + +V+L Sbjct: 22 KLGAGQFGEVWMATY---NKHTKVAVKTMKPGS--MSVEAFLAEANVMKTLQHDKLVKLH 76 Query: 403 GVCQAEALMLVMEMAGGGPLHKFLVGKR-EEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 V E + ++ E G L FL + P+ + + Q++ GM ++E++N++HRD Sbjct: 77 AVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRD 136 Query: 462 LAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSD 521 L A N+L+ KI+DFGL++ + +D+ YTAR K+P+KW APE INF F+ +SD Sbjct: 137 LRAANILVSASLVCKIADFGLARVI--EDNEYTAREGAKFPIKWTAPEAINFGSFTIKSD 194 Query: 522 VWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWE 581 VWS+G+ + E ++YG+ PY M PEV+ +E+G RM P CP ELY +M CW + E Sbjct: 195 VWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPE 254 Query: 582 DRPDF 586 +RP F Sbjct: 255 ERPTF 259 >4Y93-A nrPDB Length = 446 Score = 183 bits (464), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 95/245 (38%), Positives = 144/245 (58%), Gaps = 8/245 (3%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ELG G FG V+ G +R Q DVAIK++K+G+ D E + EA++M L + +V+L Sbjct: 195 ELGTGQFGVVKYGKWR---GQYDVAIKMIKEGSMSED--EFIEEAKVMMNLSHEKLVQLY 249 Query: 403 GVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 GVC + + ++ E G L +L R + E+ V M+YLE K F+HRD Sbjct: 250 GVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRD 309 Query: 462 LAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSD 521 LAARN L+ ++ K+SDFG+++ + D+ YT+ + K+P+KW +PE + + KFSS+SD Sbjct: 310 LAARNCLVNDQGVVKVSDFGMTRYVLDDE--YTSSTGSKFPVKWASPEVLMYSKFSSKSD 367 Query: 522 VWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWE 581 +W++GV MWE S G+ PY++ E I QG R+ P +YA+M CW K + Sbjct: 368 IWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLASERVYAIMYSCWHEKAD 427 Query: 582 DRPDF 586 +RP F Sbjct: 428 ERPTF 432 >5U6B-A nrPDB Length = 307 Score = 181 bits (459), Expect = 8e-46, Method: Compositional matrix adjust. Identities = 104/293 (35%), Positives = 162/293 (55%), Gaps = 17/293 (5%) Query: 323 EELKDK--KLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT-EKAD 379 EELK+K + + R + + LG G FG+V +G + VA+K +K +++ Sbjct: 9 EELKEKLRDVMVDRHKVALGKT-LGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSE 67 Query: 380 TEEMMREAQIMHQLDNPYIVRLIGVC----QAEAL---MLVMEMAGGGPLHKFLVGKR-- 430 E+ + EA M + D+P ++RLIGVC + E+ ++++ G LH FL+ R Sbjct: 68 LEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLG 127 Query: 431 ---EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALG 487 +P + + + ++ GM+YL K F+HRDLAARN +L ++DFGLSK + Sbjct: 128 DQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIY 187 Query: 488 ADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPE 547 D Y R A K P+KW A E + R ++S+SDVWS+GVTMWE + GQ PY ++ E Sbjct: 188 NGDYYRQGRIA-KMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSE 246 Query: 548 VMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL 600 + ++ QG R++ P +C LYALMS CW +DRP F + + + +L Sbjct: 247 IYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKAL 299 >2DQ7-X nrPDB Length = 283 Score = 180 bits (457), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 98/244 (40%), Positives = 143/244 (58%), Gaps = 8/244 (3%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LG G FG V G + K VAIK LK GT E + EAQIM +L + +V+L Sbjct: 17 LGNGQFGEVWMGTWNGNTK---VAIKTLKPGT--MSPESFLEEAQIMKKLKHDKLVQLYA 71 Query: 404 VCQAEALMLVMEMAGGGPLHKFLV-GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 V E + +V E G L FL G+ + + N+ ++ QV+ GM Y+E N++HRDL Sbjct: 72 VVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDL 131 Query: 463 AARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDV 522 + N+L+ N KI+DFGL++ + +D+ YTAR K+P+KW APE + +F+ +SDV Sbjct: 132 RSANILVGNGLICKIADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 189 Query: 523 WSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWED 582 WS+G+ + E ++ G+ PY M EV+ +E+G RM CP +CP L+ LM CW E+ Sbjct: 190 WSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEE 249 Query: 583 RPDF 586 RP F Sbjct: 250 RPTF 253 >6E4F-A nrPDB Length = 290 Score = 179 bits (455), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 95/245 (38%), Positives = 142/245 (57%), Gaps = 8/245 (3%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ELG G FG V+ G +R Q DVAIK++K+G+ D E + EA++M L + +V+L Sbjct: 38 ELGTGQFGVVKYGKWR---GQYDVAIKMIKEGSMSED--EFIEEAKVMMNLSHEKLVQLY 92 Query: 403 GVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 GVC + + ++ E G L +L R + E+ V M+YLE K F+HRD Sbjct: 93 GVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRD 152 Query: 462 LAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSD 521 LAARN L+ ++ K+SDFGLS+ + D+ YT+ K+P++W PE + + KFSS+SD Sbjct: 153 LAARNCLVNDQGVVKVSDFGLSRYVLDDE--YTSSVGSKFPVRWSPPEVLMYSKFSSKSD 210 Query: 522 VWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWE 581 +W++GV MWE S G+ PY++ E I QG R+ P ++Y +M CW K + Sbjct: 211 IWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKAD 270 Query: 582 DRPDF 586 +RP F Sbjct: 271 ERPTF 275 >4XCU-A nrPDB Length = 300 Score = 177 bits (449), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 102/266 (38%), Positives = 152/266 (57%), Gaps = 15/266 (5%) Query: 334 RDNLLIADIELGCGNFGSV-RQGVYRMRKKQID----VAIKVLKQGTEKADTEEMMREAQ 388 RD L++ LG G FG V R + M + D VA+K+LK D +++ E + Sbjct: 16 RDRLVLGK-PLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEME 74 Query: 389 IMHQLD-NPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKR----EEIPVS--NVAE 440 +M + + I+ L+GVC E L +++E A G L +FL +R E P+S + Sbjct: 75 VMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVS 134 Query: 441 LLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK 500 +QV+ GM+YLE + +HRDLAARNVL+ + KI+DFGL++ + D YY S G+ Sbjct: 135 CAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHID-YYKKTSNGR 193 Query: 501 WPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMEC 560 P+KW APE + R ++ +SDVWS+G+ +WE + G PY + E+ + + +G RM+ Sbjct: 194 LPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDR 253 Query: 561 PPECPPELYALMSDCWIYKWEDRPDF 586 PP CPPELY LM +CW RP F Sbjct: 254 PPHCPPELYGLMRECWHAAPSQRPTF 279 >3QUP-A nrPDB Length = 323 Score = 176 bits (447), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 93/257 (36%), Positives = 142/257 (55%), Gaps = 15/257 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQ-IDVAIKVLKQGT-EKADTEEMMREAQIMHQLDNPYIVRL 401 LG G FGSVR+ + + VA+K+LK +D EE +REA M + D+P++ +L Sbjct: 31 LGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKL 90 Query: 402 IGVCQAEAL-------MLVMEMAGGGPLHKFLVGKRE-----EIPVSNVAELLHQVSMGM 449 +GV M+++ G LH FL+ R +P+ + + ++ GM Sbjct: 91 VGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFMVDIACGM 150 Query: 450 KYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPE 509 +YL +NF+HRDLAARN +L ++DFGLS+ + + D YY A K P+KW A E Sbjct: 151 EYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGD-YYRQGCASKLPVKWLALE 209 Query: 510 CINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELY 569 + ++ SDVW++GVTMWE ++ GQ PY ++ E+ ++ G R++ PPEC E+Y Sbjct: 210 SLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEEVY 269 Query: 570 ALMSDCWIYKWEDRPDF 586 LM CW + RP F Sbjct: 270 DLMYQCWSADPKQRPSF 286 >5U6C-A nrPDB Length = 315 Score = 176 bits (447), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 104/297 (35%), Positives = 166/297 (55%), Gaps = 17/297 (5%) Query: 319 YSDPEELKDK--KLFLKRDNLLIADIELGCGNFGSVRQGVYRMRK-KQIDVAIKVLK-QG 374 + EEL++K + + R NLLI LG G FGSV +G + + VA+K +K Sbjct: 18 FQGSEELQNKLEDVVIDR-NLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDN 76 Query: 375 TEKADTEEMMREAQIMHQLDNPYIVRLIGVC---QAEAL---MLVMEMAGGGPLHKFLVG 428 + + + EE + EA M +P ++RL+GVC ++ + M+++ G LH +L+ Sbjct: 77 SSQREIEEFLSEAACMKDFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLY 136 Query: 429 KREE-----IPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLS 483 R E IP+ + + + +++GM+YL +NF+HRDLAARN +L + ++DFGLS Sbjct: 137 SRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLS 196 Query: 484 KALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKM 543 K + + D Y R A K P+KW A E + R ++S+SDVW++GVTMWE + G PY + Sbjct: 197 KKIYSGDYYRQGRIA-KMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGV 255 Query: 544 KGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL 600 + E+ ++ G R++ P +C ELY +M CW DRP F + ++ SL Sbjct: 256 QNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESL 312 >3A4O-X nrPDB Length = 286 Score = 176 bits (447), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 101/269 (37%), Positives = 149/269 (55%), Gaps = 13/269 (4%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LG G FG V G Y K VA+K LK GT + + EA +M L + +VRL Sbjct: 21 LGAGQFGEVWMGYYNNSTK---VAVKTLKPGT--MSVQAFLEEANLMKTLQHDKLVRLYA 75 Query: 404 VC-QAEALMLVMEMAGGGPLHKFLVGKREE---IPVSNVAELLHQVSMGMKYLEEKNFVH 459 V + E + ++ E G L FL K +E + + + + Q++ GM Y+E KN++H Sbjct: 76 VVTREEPIYIITEYMAKGSLLDFL--KSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIH 133 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 519 RDL A NVL+ KI+DFGL++ + +D+ YTAR K+P+KW APE INF F+ + Sbjct: 134 RDLRAANVLVSESLMCKIADFGLARVI--EDNEYTAREGAKFPIKWTAPEAINFGCFTIK 191 Query: 520 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYK 579 SDVWS+G+ ++E ++YG+ PY +VM + QG RM CP ELY +M CW K Sbjct: 192 SDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEK 251 Query: 580 WEDRPDFLTVEQRMRACYYSLASKVEGPP 608 E+RP F ++ + Y + + + P Sbjct: 252 AEERPTFDYLQSVLDDFYTATEGQYQQQP 280 >5WNO-A nrPDB Length = 330 Score = 176 bits (446), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 95/258 (36%), Positives = 149/258 (57%), Gaps = 7/258 (2%) Query: 341 DIELGCGNFGSVRQGVY---RMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPY 397 D +LG G FG+V G+Y R + +I VAIKV + T+++ T+EM+ EA M +L + Sbjct: 27 DKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQ--TDQSQTDEMLEEATNMFRLRHDN 84 Query: 398 IVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 ++++IG C + L +V G L FL +E + +Q++ GM+YLE++ Sbjct: 85 LLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQR 144 Query: 457 FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKF 516 VHRDLA RNVL+ ++ +I+DFGLSK L D T +S GK +KW A E + + Sbjct: 145 VVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKS-GKVAIKWLAIEIFSKHCY 203 Query: 517 SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCW 576 + SDVW++GVT WE +++GQ PY+ M + F++ G R+ PP C +LY + CW Sbjct: 204 THASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCW 263 Query: 577 IYKWEDRPDFLTVEQRMR 594 + + RP F + +R + Sbjct: 264 MADPKSRPGFEILYERFK 281 >5SYS-A nrPDB Length = 286 Score = 176 bits (446), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 97/256 (37%), Positives = 151/256 (58%), Gaps = 9/256 (3%) Query: 332 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMH 391 + R++L + +++LG G FG G + + VAIK LK GT E ++EAQ+M Sbjct: 15 IPRESLRL-EVKLGQGCFGECWMGTWNGTTR---VAIKTLKPGT--MSPEAFLQEAQVMK 68 Query: 392 QLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREE-IPVSNVAELLHQVSMGMK 450 +L + +V+L V E + +V E G L FL G+ + + + + ++ Q++ GM Sbjct: 69 KLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMA 128 Query: 451 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510 Y+E N+VHRDL A N+L+ K++DFGL++ + +D+ YTAR K+P+KW APE Sbjct: 129 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEA 186 Query: 511 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYA 570 + +F+ +SDVWS+G+ + E + G+ PY M EV+ +E+G RM CPPECP L+ Sbjct: 187 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 246 Query: 571 LMSDCWIYKWEDRPDF 586 LM CW E+RP F Sbjct: 247 LMCQCWRKDPEERPTF 262 >3SXS-A nrPDB Length = 268 Score = 174 bits (440), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 97/256 (37%), Positives = 144/256 (56%), Gaps = 9/256 (3%) Query: 332 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMH 391 LKR+ + + ELG G FG V+ G + K Q DVA+K++K+G+ D E +EAQ M Sbjct: 5 LKREEITLLK-ELGSGQFGVVKLGKW---KGQYDVAVKMIKEGSMSED--EFFQEAQTMM 58 Query: 392 QLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMK 450 +L +P +V+ GVC E + +V E G L +L + + S + E+ + V GM Sbjct: 59 KLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMA 118 Query: 451 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510 +LE F+HRDLAARN L+ K+SDFG+++ + D Y + K+P+KW APE Sbjct: 119 FLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQ--YVSSVGTKFPVKWSAPEV 176 Query: 511 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYA 570 ++ K+SS+SDVW++G+ MWE S G+ PY EV+ + QG R+ P +Y Sbjct: 177 FHYFKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQ 236 Query: 571 LMSDCWIYKWEDRPDF 586 +M CW E RP F Sbjct: 237 IMYSCWHELPEKRPTF 252 >1LUF-A nrPDB Length = 343 Score = 172 bits (437), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 104/282 (36%), Positives = 148/282 (52%), Gaps = 33/282 (11%) Query: 343 ELGCGNFGSVRQ----GVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYI 398 ++G G FG V Q G+ + VA+K+LK+ + REA +M + DNP I Sbjct: 54 DIGEGAFGRVFQARAPGLLPYEPFTM-VAVKMLKEEASADMQADFQREAALMAEFDNPNI 112 Query: 399 VRLIGVCQA-EALMLVMEMAGGGPLHKFL---------------VGKREEI------PVS 436 V+L+GVC + + L+ E G L++FL + R + P+S Sbjct: 113 VKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPPLS 172 Query: 437 NVAELL--HQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYT 494 +L QV+ GM YL E+ FVHRDLA RN L+ KI+DFGLS+ + + D YY Sbjct: 173 CAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSAD-YYK 231 Query: 495 ARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 554 A P++W PE I + ++++ SDVW+YGV +WE SYG +PY M EV+ ++ Sbjct: 232 ADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRD 291 Query: 555 GKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVE---QRM 593 G + CP CP ELY LM CW DRP F ++ QRM Sbjct: 292 GNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRILQRM 333 >3QGY-A nrPDB Length = 286 Score = 172 bits (437), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 95/245 (38%), Positives = 140/245 (57%), Gaps = 8/245 (3%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 E+G G FG V G + + K VAIK +K+G+ D + + EA++M +L +P +V+L Sbjct: 34 EIGSGQFGLVHLGYWLNKDK---VAIKTIKEGSMSED--DFIEEAEVMMKLSHPKLVQLY 88 Query: 403 GVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 GVC +A + LV E G L +L +R + + V GM YLEE +HRD Sbjct: 89 GVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRD 148 Query: 462 LAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSD 521 LAARN L+ K+SDFG+++ + D YT+ + K+P+KW +PE +F ++SS+SD Sbjct: 149 LAARNCLVGENQVIKVSDFGMTRFVLDDQ--YTSSTGTKFPVKWASPEVFSFSRYSSKSD 206 Query: 522 VWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWE 581 VWS+GV MWE S G+ PY+ EV+ I G R+ P +Y +M+ CW + E Sbjct: 207 VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE 266 Query: 582 DRPDF 586 DRP F Sbjct: 267 DRPAF 271 >5AMN-A nrPDB Length = 299 Score = 172 bits (437), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 97/282 (34%), Positives = 155/282 (54%), Gaps = 15/282 (5%) Query: 325 LKDKKLFLKRDNLLIADIELGCGNFGSVRQGV---YRMRKKQIDVAIKVLKQGTEKADTE 381 L+D K R NL++ LG G FG V + + R VA+K+LK+ ++ Sbjct: 13 LEDPKWEFPRKNLVLGKT-LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELR 71 Query: 382 EMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIP------ 434 +++ E ++ Q+++P++++L G C + L+L++E A G L FL R+ P Sbjct: 72 DLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDER 131 Query: 435 ---VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDS 491 + ++ Q+S GM+YL E VHRDLAARN+L+ KISDFGLS+ + +DS Sbjct: 132 ALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDS 191 Query: 492 YYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAF 551 Y RS G+ P+KW A E + ++++SDVWS+GV +WE ++ G PY + + Sbjct: 192 Y-VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNL 250 Query: 552 IEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRM 593 ++ G RME P C E+Y LM CW + + RP F + + + Sbjct: 251 LKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL 292 >1BYG-A nrPDB Length = 278 Score = 170 bits (431), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 96/253 (37%), Positives = 144/253 (56%), Gaps = 16/253 (6%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G G FG V G YR K VA+K +K A + + EA +M QL + +V+L+G Sbjct: 29 IGKGEFGDVMLGDYRGNK----VAVKCIKN---DATAQAFLAEASVMTQLRHSNLVQLLG 81 Query: 404 VCQAE--ALMLVMEMAGGGPLHKFLVGK-REEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 V E L +V E G L +L + R + + + V M+YLE NFVHR Sbjct: 82 VIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHR 141 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRS 520 DLAARNVL+ + AK+SDFGL+K + + GK P+KW APE + +KFS++S Sbjct: 142 DLAARNVLVSEDNVAKVSDFGLTKEAS------STQDTGKLPVKWTAPEALREKKFSTKS 195 Query: 521 DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKW 580 DVWS+G+ +WE S+G+ PY ++ +V+ +E+G +M+ P CPP +Y +M +CW Sbjct: 196 DVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDA 255 Query: 581 EDRPDFLTVEQRM 593 RP FL + +++ Sbjct: 256 AMRPSFLQLREQL 268 >5KMM-A nrPDB Length = 329 Score = 170 bits (430), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 100/293 (34%), Positives = 158/293 (53%), Gaps = 20/293 (6%) Query: 321 DPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQG-VYRMRKKQ--IDVAIKVLKQGTEK 377 +P+ D + + ++ ELG G FG V + + +Q + VA+K LK+ +E Sbjct: 20 NPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASES 79 Query: 378 ADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFL---------- 426 A ++ REA+++ L + +IVR GVC + L++V E G L++FL Sbjct: 80 A-RQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLL 138 Query: 427 VGKREEIP----VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGL 482 G + P + + + QV+ GM YL +FVHRDLA RN L+ KI DFG+ Sbjct: 139 AGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGM 198 Query: 483 SKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKK 542 S+ + + D YY P++W PE I +RKF++ SDVWS+GV +WE +YG++P+ + Sbjct: 199 SRDIYSTD-YYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQ 257 Query: 543 MKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRA 595 + E + I QG+ +E P CPPE+YA+M CW + + R V R++A Sbjct: 258 LSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQA 310 >6DBN-A nrPDB Length = 316 Score = 169 bits (427), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 102/278 (36%), Positives = 147/278 (52%), Gaps = 25/278 (8%) Query: 328 KKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQI--DVAIKVLKQGTEKADTEEMMR 385 +K FLKR I D LG G+FG V Y VA+K LK + ++ + Sbjct: 33 EKRFLKR----IRD--LGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKK 86 Query: 386 EAQIMHQLDNPYIVRLIGVCQAEA---LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELL 442 E +I+ L + IV+ G+C + + L+ME G L ++L + +I + + Sbjct: 87 EIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYA 146 Query: 443 HQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWP 502 Q+ GM YL + +VHRDLAARNVL+ + H KI DFGL+KA+ D YYT + P Sbjct: 147 VQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSP 206 Query: 503 LKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKP------YKKMKGP--------EV 548 + WYAPEC+ KF SDVWS+GVT+ E L+Y + KM GP + Sbjct: 207 VFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRL 266 Query: 549 MAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586 + +++GKR+ CPP CP E+Y LM CW ++ +R F Sbjct: 267 VNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSF 304 >5FM2-A nrPDB Length = 355 Score = 168 bits (426), Expect = 6e-42, Method: Compositional matrix adjust. Identities = 97/296 (32%), Positives = 155/296 (52%), Gaps = 29/296 (9%) Query: 325 LKDKKLFLKRDNLLIADIELGCGNFGSVRQGV---YRMRKKQIDVAIKVLKQGTEKADTE 381 L+D K R NL++ LG G FG V + + R VA+K+LK+ ++ Sbjct: 54 LEDPKWEFPRKNLVLGKT-LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELR 112 Query: 382 EMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIP------ 434 +++ E ++ Q+++P++++L G C + L+L++E A G L FL R+ P Sbjct: 113 DLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSG 172 Query: 435 -----------------VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKI 477 + ++ Q+S GM+YL E VHRDLAARN+L+ KI Sbjct: 173 GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKI 232 Query: 478 SDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQ 537 SDFGLS+ + +DSY RS G+ P+KW A E + ++++SDVWS+GV +WE ++ G Sbjct: 233 SDFGLSRDVYEEDSY-VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGG 291 Query: 538 KPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRM 593 PY + + ++ G RME P C E+Y LM CW + + RP F + + + Sbjct: 292 NPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL 347 >5HLW-A nrPDB Length = 299 Score = 167 bits (424), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 89/262 (33%), Positives = 145/262 (55%), Gaps = 6/262 (2%) Query: 344 LGCGNFGSVRQG-VYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 +G G+FG V G + K+I A+K L + T+ + + + E IM +P ++ L+ Sbjct: 28 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLL 87 Query: 403 GVC--QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 G+C + ++V+ G L F+ + V ++ QV+ GMKYL K FVHR Sbjct: 88 GICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHR 147 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTA--RSAGKWPLKWYAPECINFRKFSS 518 DLAARN +L + K++DFGL++ + D YY+ ++ K P+KW A E + +KF++ Sbjct: 148 DLAARNCMLDEKFTVKVADFGLARDM-HDKEYYSVHNKTGAKLPVKWMALESLQTQKFTT 206 Query: 519 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIY 578 +SDVWS+GV +WE ++ G PY + ++ ++ QG+R+ P CP LY +M CW Sbjct: 207 KSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHP 266 Query: 579 KWEDRPDFLTVEQRMRACYYSL 600 K E RP F + R+ A + + Sbjct: 267 KAEMRPSFSELVSRISAIFSTF 288 >3ZBF-A nrPDB Length = 322 Score = 167 bits (423), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 91/267 (34%), Positives = 153/267 (57%), Gaps = 17/267 (6%) Query: 344 LGCGNFGSVRQG----VYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIV 399 LG G FG V +G + + +I VA+K LK+G+ + E ++EA +M + ++P I+ Sbjct: 41 LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNIL 100 Query: 400 RLIGVCQ-AEALMLVMEMAGGGPLHKFLVGKREEI------PVSNVAELLHQVSMGMKYL 452 + +GVC E +++E+ GG L +L R + ++ +L +S G YL Sbjct: 101 KQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYL 160 Query: 453 EEKNFVHRDLAARNVLLVNRHY-----AKISDFGLSKALGADDSYYTARSAGKWPLKWYA 507 E +F+HRDLAARN L+ + Y KI DFGL++ + +D YY R G P++W A Sbjct: 161 ERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKND-YYRKRGEGLLPVRWMA 219 Query: 508 PECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPE 567 PE + F+++SDVWS+G+ +WE L+ G +PY +V+ +++ G R+E P CP + Sbjct: 220 PESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDD 279 Query: 568 LYALMSDCWIYKWEDRPDFLTVEQRMR 594 L+ LM+ CW + + RP F ++ +++ Sbjct: 280 LWNLMTQCWAQEPDQRPTFHRIQDQLQ 306 >4AT3-A nrPDB Length = 299 Score = 167 bits (423), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 95/261 (36%), Positives = 147/261 (56%), Gaps = 19/261 (7%) Query: 332 LKRDNLLIADIELGCGNFGSVRQG-VYRM--RKKQIDVAIKVLKQGTEKADTEEMMREAQ 388 +KR N+++ ELG G FG V Y + + +I VA+K LK ++ A ++ REA+ Sbjct: 10 IKRHNIVLKR-ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNA-RKDFHREAE 67 Query: 389 IMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKR------------EEIPV 435 ++ L + +IV+ GVC + + L++V E G L+KFL E+ Sbjct: 68 LLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQ 127 Query: 436 SNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTA 495 S + + Q++ GM YL ++FVHRDLA RN L+ KI DFG+S+ + + D YY Sbjct: 128 SQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTD-YYRV 186 Query: 496 RSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG 555 P++W PE I +RKF++ SDVWS GV +WE +YG++P+ ++ EV+ I QG Sbjct: 187 GGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQG 246 Query: 556 KRMECPPECPPELYALMSDCW 576 + ++ P CP E+Y LM CW Sbjct: 247 RVLQRPRTCPQEVYELMLGCW 267 >3I81-A nrPDB Length = 315 Score = 167 bits (422), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 95/289 (32%), Positives = 155/289 (53%), Gaps = 24/289 (8%) Query: 343 ELGCGNFGSVRQGVYRMRKK---QIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIV 399 ELG G+FG V +GV + K + VAIK + + + E + EA +M + + ++V Sbjct: 25 ELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVV 84 Query: 400 RLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEI---PV------SNVAELLHQVSMGM 449 RL+GV Q + +++ME+ G L +L R E+ PV S + ++ +++ GM Sbjct: 85 RLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGM 144 Query: 450 KYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPE 509 YL FVHRDLAARN ++ KI DFG+++ + D YY G P++W +PE Sbjct: 145 AYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETD-YYRKGGKGLLPVRWMSPE 203 Query: 510 CINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELY 569 + F++ SDVWS+GV +WE + ++PY+ + +V+ F+ +G ++ P CP L+ Sbjct: 204 SLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLF 263 Query: 570 ALMSDCWIYKWEDRPDFLTVEQRMR----------ACYYSLASKVEGPP 608 LM CW Y + RP FL + ++ + YYS +K+E P Sbjct: 264 ELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKMENNP 312 >1FVR-A nrPDB Length = 327 Score = 166 bits (420), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 98/263 (37%), Positives = 143/263 (54%), Gaps = 21/263 (7%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL-DNPYIVRLI 402 +G GNFG V + + ++D AIK +K+ K D + E +++ +L +P I+ L+ Sbjct: 33 IGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLL 92 Query: 403 GVCQAEA-LMLVMEMAGGGPLHKFLVGKR--EEIPVSNVA----------ELLH---QVS 446 G C+ L L +E A G L FL R E P +A +LLH V+ Sbjct: 93 GACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVA 152 Query: 447 MGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY 506 GM YL +K F+HRDLAARN+L+ + AKI+DFGLS+ Y ++ G+ P++W Sbjct: 153 RGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRG----QEVYVKKTMGRLPVRWM 208 Query: 507 APECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPP 566 A E +N+ +++ SDVWSYGV +WE +S G PY M E+ + QG R+E P C Sbjct: 209 AIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDD 268 Query: 567 ELYALMSDCWIYKWEDRPDFLTV 589 E+Y LM CW K +RP F + Sbjct: 269 EVYDLMRQCWREKPYERPSFAQI 291 >5A46-A nrPDB Length = 386 Score = 166 bits (420), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 105/322 (32%), Positives = 168/322 (52%), Gaps = 33/322 (10%) Query: 287 LNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGC 346 +NS P+R++S P M S YE P +D + L RD L++ LG Sbjct: 1 MNSGVLLVRPSRLSSSGTP--MLAGVSEYELP-------EDPRWELPRDRLVLGK-PLGE 50 Query: 347 GNFGSV----RQGVYRMRKKQI-DVAIKVLKQGTEKADTEEMMREAQIMHQL-DNPYIVR 400 G FG V G+ + + ++ VA+K+LK + D +++ E ++M + + I+ Sbjct: 51 GCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIIN 110 Query: 401 LIGVCQAEA-LMLVMEMAGGGPLHKFLVGKR---------------EEIPVSNVAELLHQ 444 L+G C + L +++E A G L ++L +R E++ ++ +Q Sbjct: 111 LLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQ 170 Query: 445 VSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLK 504 V+ GM+YL K +HRDLAARNVL+ + KI+DFGL++ + D YY + G+ P+K Sbjct: 171 VARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHID-YYKKTTNGRLPVK 229 Query: 505 WYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPEC 564 W APE + R ++ +SDVWS+GV +WE + G PY + E+ +++G RM+ P C Sbjct: 230 WMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNC 289 Query: 565 PPELYALMSDCWIYKWEDRPDF 586 ELY +M DCW RP F Sbjct: 290 TNELYMMMRDCWHAVPSQRPTF 311 >3AOX-A nrPDB Length = 344 Score = 165 bits (417), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 105/293 (35%), Positives = 154/293 (52%), Gaps = 22/293 (7%) Query: 317 SPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQG-VYRMRK--KQIDVAIKVLKQ 373 S SD +E+ K + L R LG G FG V +G V M + VA+K L + Sbjct: 36 SSISDLKEVPRKNITLIRG--------LGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPE 87 Query: 374 GTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFL--VGKR 430 + D + + EA I+ + ++ IVR IGV Q+ +++E+ GG L FL R Sbjct: 88 VCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPR 147 Query: 431 EEIPVS-NVAELLH---QVSMGMKYLEEKNFVHRDLAARNVLLV---NRHYAKISDFGLS 483 P S + +LLH ++ G +YLEE +F+HRD+AARN LL AKI DFG++ Sbjct: 148 PSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMA 207 Query: 484 KALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKM 543 + + SYY P+KW PE F+S++D WS+GV +WE S G PY Sbjct: 208 RDI-YRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSK 266 Query: 544 KGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRAC 596 EV+ F+ G RM+ P CP +Y +M+ CW ++ EDRP+F + +R+ C Sbjct: 267 SNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYC 319 >2PSQ-A nrPDB Length = 370 Score = 165 bits (417), Expect = 7e-41, Method: Compositional matrix adjust. Identities = 100/302 (33%), Positives = 158/302 (52%), Gaps = 31/302 (10%) Query: 307 PMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQ----GVYRMRKK 362 PM S YE P +D K RD L + LG G FG V G+ + + K Sbjct: 60 PMLAGVSEYELP-------EDPKWEFPRDKLTLGK-PLGEGCFGQVVMAEAVGIDKDKPK 111 Query: 363 Q-IDVAIKVLKQGTEKADTEEMMREAQIMHQL-DNPYIVRLIGVCQAEA-LMLVMEMAGG 419 + + VA+K+LK + D +++ E ++M + + I+ L+G C + L +++E A Sbjct: 112 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 171 Query: 420 GPLHKFLVGKR---------------EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAA 464 G L ++L +R E++ ++ +Q++ GM+YL + +HRDLAA Sbjct: 172 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 231 Query: 465 RNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWS 524 RNVL+ + KI+DFGL++ + D YY + G+ P+KW APE + R ++ +SDVWS Sbjct: 232 RNVLVTENNVMKIADFGLARDINNID-YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 290 Query: 525 YGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRP 584 +GV MWE + G PY + E+ +++G RM+ P C ELY +M DCW RP Sbjct: 291 FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 350 Query: 585 DF 586 F Sbjct: 351 TF 352 >3V5Q-A nrPDB Length = 297 Score = 163 bits (413), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 97/273 (35%), Positives = 149/273 (54%), Gaps = 29/273 (10%) Query: 323 EELKDKKLFLKRDNLLIADIELGCGNFGSVRQG-VYRMR--KKQIDVAIKVLKQGTEKAD 379 + +K + + LKR ELG G FG V Y + K ++ VA+K LK T A Sbjct: 10 QHIKRRDIVLKR--------ELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAA- 60 Query: 380 TEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGK--------- 429 ++ REA+++ L + +IV+ GVC + L++V E G L+KFL Sbjct: 61 RKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVD 120 Query: 430 ------REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLS 483 + E+ +S + + Q++ GM YL ++FVHRDLA RN L+ KI DFG+S Sbjct: 121 GQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMS 180 Query: 484 KALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKM 543 + + + D YY P++W PE I +RKF++ SDVWS+GV +WE +YG++P+ ++ Sbjct: 181 RDVYSTD-YYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQL 239 Query: 544 KGPEVMAFIEQGKRMECPPECPPELYALMSDCW 576 EV+ I QG+ +E P CP E+Y +M CW Sbjct: 240 SNTEVIECITQGRVLERPRVCPKEVYDVMLGCW 272 >3C1X-A nrPDB Length = 373 Score = 162 bits (409), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 87/262 (33%), Positives = 144/262 (54%), Gaps = 6/262 (2%) Query: 344 LGCGNFGSVRQG-VYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 +G G+FG V G + K+I A+K L + T+ + + + E IM +P ++ L+ Sbjct: 97 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLL 156 Query: 403 GVC--QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 G+C + ++V+ G L F+ + V ++ QV+ GMK+L K FVHR Sbjct: 157 GICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFLASKKFVHR 216 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGAD--DSYYTARSAGKWPLKWYAPECINFRKFSS 518 DLAARN +L + K++DFGL++ + DS + ++ K P+KW A E + +KF++ Sbjct: 217 DLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHN-KTGAKLPVKWMALESLQTQKFTT 275 Query: 519 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIY 578 +SDVWS+GV +WE ++ G PY + ++ ++ QG+R+ P CP LY +M CW Sbjct: 276 KSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHP 335 Query: 579 KWEDRPDFLTVEQRMRACYYSL 600 K E RP F + R+ A + + Sbjct: 336 KAEMRPSFSELVSRISAIFSTF 357 >5H2U-A nrPDB Length = 267 Score = 162 bits (409), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 92/255 (36%), Positives = 144/255 (56%), Gaps = 9/255 (3%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 +LG G FG V +G++ K ++ VAIKV+ + + + E Q M +L + +I+ L Sbjct: 13 KLGSGYFGEVFEGLW---KDRVQVAIKVISRDN-LLHQQMLQSEIQAMKKLRHKHILALY 68 Query: 403 GVCQA-EALMLVMEMAGGGPLHKFLVGKREEI-PVSNVAELLHQVSMGMKYLEEKNFVHR 460 V + + ++ E+ G L + L E++ PVS + ++ QV+ GM YLE +N++HR Sbjct: 69 AVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHR 128 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRS 520 DLAARN+L+ K+ DFGL++ L +D Y + P KW APE ++ +S++S Sbjct: 129 DLAARNILVGENTLCKVGDFGLAR-LIKEDVYLS--HDHNIPYKWTAPEALSRGHYSTKS 185 Query: 521 DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKW 580 DVWS+G+ + E S GQ PY M E ++ G RM CP ECPP ++ LM CW Sbjct: 186 DVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDP 245 Query: 581 EDRPDFLTVEQRMRA 595 E RP F + +R+ + Sbjct: 246 EQRPTFKALRERLSS 260 >3ZZW-A nrPDB Length = 289 Score = 161 bits (407), Expect = 8e-40, Method: Compositional matrix adjust. Identities = 98/272 (36%), Positives = 139/272 (51%), Gaps = 20/272 (7%) Query: 343 ELGCGNFGSVRQGVY---RMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIV 399 ELG FG V +G ++ VAIK LK E EE EA + +L +P +V Sbjct: 16 ELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVV 75 Query: 400 RLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPVS---------------NVAELLH 443 L+GV + + L ++ G LH+FLV + V + L+ Sbjct: 76 CLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVA 135 Query: 444 QVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPL 503 Q++ GM+YL + VH+DLA RNVL+ ++ KISD GL + + A D YY P+ Sbjct: 136 QIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAAD-YYKLLGNSLLPI 194 Query: 504 KWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE 563 +W APE I + KFS SD+WSYGV +WE SYG +PY +V+ I + + CP + Sbjct: 195 RWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDD 254 Query: 564 CPPELYALMSDCWIYKWEDRPDFLTVEQRMRA 595 CP +YALM +CW RP F + R+RA Sbjct: 255 CPAWVYALMIECWNEFPSRRPRFKDIHSRLRA 286 >3LMG-A nrPDB Length = 344 Score = 161 bits (407), Expect = 8e-40, Method: Compositional matrix adjust. Identities = 96/270 (35%), Positives = 147/270 (54%), Gaps = 6/270 (2%) Query: 321 DPEELKDKKL--FLKRDNLLIADIELGCGNFGSVRQGVY--RMRKKQIDVAIKVLKQGTE 376 DP E +K L K L + LG G FG+V +GV+ +I V IKV++ + Sbjct: 15 DPSEKANKVLARIFKETELRKLKV-LGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSG 73 Query: 377 KADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVS 436 + + + + LD+ +IVRL+G+C +L LV + G L + R + Sbjct: 74 RQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQ 133 Query: 437 NVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTAR 496 + Q++ GM YLEE VHR+LAARNVLL + +++DFG++ L DD Sbjct: 134 LLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLL-Y 192 Query: 497 SAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK 556 S K P+KW A E I+F K++ +SDVWSYGVT+WE +++G +PY ++ EV +E+G+ Sbjct: 193 SEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGE 252 Query: 557 RMECPPECPPELYALMSDCWIYKWEDRPDF 586 R+ P C ++Y +M CW+ RP F Sbjct: 253 RLAQPQICTIDVYMVMVKCWMIDENIRPTF 282 >3TT0-A nrPDB Length = 382 Score = 160 bits (406), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 98/292 (33%), Positives = 156/292 (53%), Gaps = 27/292 (9%) Query: 317 SPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSV----RQGVYRMRKKQI-DVAIKVL 371 S Y PE D + L RD L++ LG G FG V G+ + + ++ VA+K+L Sbjct: 54 SEYELPE---DPRWELPRDRLVLGK-PLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKML 109 Query: 372 KQGTEKADTEEMMREAQIMHQL-DNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGK 429 K + D +++ E ++M + + I+ L+G C + L +++E A G L ++L + Sbjct: 110 KSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQAR 169 Query: 430 R---------------EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHY 474 R E++ ++ +QV+ GM+YL K +HRDLAARNVL+ + Sbjct: 170 RPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV 229 Query: 475 AKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALS 534 KI+DFGL++ + D YY + G+ P+KW APE + R ++ +SDVWS+GV +WE + Sbjct: 230 MKIADFGLARDIHHID-YYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT 288 Query: 535 YGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586 G PY + E+ +++G RM+ P C ELY +M DCW RP F Sbjct: 289 LGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTF 340 >2W1I-A nrPDB Length = 326 Score = 160 bits (406), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 99/294 (33%), Positives = 151/294 (51%), Gaps = 31/294 (10%) Query: 321 DPEELKDKKL-FLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEK 377 DP + +++ L FL+ +LG GNFGSV Y + VA+K L+ TE+ Sbjct: 34 DPTQFEERHLKFLQ---------QLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEE 84 Query: 378 ADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA---LMLVMEMAGGGPLHKFLVGKREEIP 434 + RE +I+ L + IV+ GVC + L L+ME G L +L +E I Sbjct: 85 H-LRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERID 143 Query: 435 VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYT 494 + + Q+ GM+YL K ++HRDLA RN+L+ N + KI DFGL+K L D YY Sbjct: 144 HIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYK 203 Query: 495 ARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKP------YKKMKGPE- 547 + G+ P+ WYAPE + KFS SDVWS+GV ++E +Y +K + +M G + Sbjct: 204 VKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDK 263 Query: 548 --------VMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRM 593 ++ ++ R+ P CP E+Y +M++CW RP F + R+ Sbjct: 264 QGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRV 317 >3GQL-A nrPDB Length = 326 Score = 160 bits (405), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 98/292 (33%), Positives = 156/292 (53%), Gaps = 27/292 (9%) Query: 317 SPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSV----RQGVYRMRKKQI-DVAIKVL 371 S Y PE D + L RD L++ LG G FG V G+ + + ++ VA+K+L Sbjct: 13 SEYELPE---DPRWELPRDRLVLGK-PLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKML 68 Query: 372 KQGTEKADTEEMMREAQIMHQL-DNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGK 429 K + D +++ E ++M + + I+ L+G C + L +++E A G L ++L + Sbjct: 69 KSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQAR 128 Query: 430 R---------------EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHY 474 R E++ ++ +QV+ GM+YL K +HRDLAARNVL+ + Sbjct: 129 RPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV 188 Query: 475 AKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALS 534 KI+DFGL++ + D YY + G+ P+KW APE + R ++ +SDVWS+GV +WE + Sbjct: 189 MKIADFGLARDIHHID-YYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT 247 Query: 535 YGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586 G PY + E+ +++G RM+ P C ELY +M DCW RP F Sbjct: 248 LGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTF 299 >3IO7-A nrPDB Length = 313 Score = 159 bits (403), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 95/279 (34%), Positives = 144/279 (51%), Gaps = 21/279 (7%) Query: 343 ELGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVR 400 +LG GNFGSV Y + VA+K L+ TE+ + RE +I+ L + IV+ Sbjct: 35 QLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEH-LRDFEREIEILKSLQHDNIVK 93 Query: 401 LIGVCQAEA---LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNF 457 GVC + L L+ME G L +L +E I + + Q+ GM+YL K + Sbjct: 94 YKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRY 153 Query: 458 VHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFS 517 +HRDLA RN+L+ N + KI DFGL+K L D YY + G+ P+ WYAPE + KFS Sbjct: 154 IHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFS 213 Query: 518 SRSDVWSYGVTMWEALSYGQKP------YKKMKGPE---------VMAFIEQGKRMECPP 562 SDVWS+GV ++E +Y +K + +M G + ++ ++ R+ P Sbjct: 214 VASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPD 273 Query: 563 ECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLA 601 CP E+Y +M++CW RP F + R+ ++A Sbjct: 274 GCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMA 312 >4HVI-A nrPDB Length = 314 Score = 159 bits (402), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 103/280 (36%), Positives = 148/280 (52%), Gaps = 22/280 (7%) Query: 326 KDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADTEEM 383 +D +F +R I+ +LG GNFGSV Y VA+K L Q + + Sbjct: 2 QDPTIFEERHLKYIS--QLGKGNFGSVELCRYDPLGDNTGALVAVKQL-QHSGPDQQRDF 58 Query: 384 MREAQIMHQLDNPYIVRLIGVCQA---EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAE 440 RE QI+ L + +IV+ GV ++L LVME G L FL R + S + Sbjct: 59 QREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLL 118 Query: 441 LLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK 500 Q+ GM+YL + VHRDLAARN+L+ + + KI+DFGL+K L D YY R G+ Sbjct: 119 YSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQ 178 Query: 501 WPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKP------YKKMKGPE------- 547 P+ WYAPE ++ FS +SDVWS+GV ++E +Y K + +M G E Sbjct: 179 SPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALS 238 Query: 548 -VMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586 ++ +E+G+R+ PP CP E++ LM CW +DRP F Sbjct: 239 RLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSF 278 >5EG3-A nrPDB Length = 334 Score = 159 bits (401), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 96/302 (31%), Positives = 157/302 (51%), Gaps = 31/302 (10%) Query: 307 PMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQ----GVYRMRKK 362 PM S +E P +D K RD L + LG G FG V G+ + + K Sbjct: 14 PMLAGVSEFELP-------EDPKWEFPRDKLTLGK-PLGEGAFGQVVMAEAVGIDKDKPK 65 Query: 363 Q-IDVAIKVLKQGTEKADTEEMMREAQIMHQL-DNPYIVRLIGVCQAEA-LMLVMEMAGG 419 + + VA+K+LK + D +++ E ++M + + I+ L+G C + L +++ A Sbjct: 66 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVAYASK 125 Query: 420 GPLHKFLVGKR---------------EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAA 464 G L ++L +R E++ ++ +Q++ GM+YL + +HRDLAA Sbjct: 126 GNLREYLRARRPPGMELSPDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 185 Query: 465 RNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWS 524 RNVL+ + KI+DFGL++ + D ++ + G+ P+KW APE + R ++ +SDVWS Sbjct: 186 RNVLVTENNVMKIADFGLARDINNID-FFKETTNGRLPVKWMAPEALFDRVYTHQSDVWS 244 Query: 525 YGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRP 584 +GV MWE + G PY + E+ +++G RM+ P C ELY +M DCW RP Sbjct: 245 FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 304 Query: 585 DF 586 F Sbjct: 305 TF 306 >4K33-A nrPDB Length = 325 Score = 158 bits (400), Expect = 6e-39, Method: Compositional matrix adjust. Identities = 90/265 (33%), Positives = 143/265 (53%), Gaps = 23/265 (8%) Query: 344 LGCGNFGSVRQ----GVYRMRK-KQIDVAIKVLKQGTEKADTEEMMREAQIMHQL-DNPY 397 LG G FG V G+ + R K + VA+K+LK D +++ E ++M + + Sbjct: 44 LGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKN 103 Query: 398 IVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKR---------------EEIPVSNVAEL 441 I+ L+G C Q L +++E A G L +FL +R E++ ++ Sbjct: 104 IINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEEQLTFKDLVSC 163 Query: 442 LHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKW 501 +QV+ GM+YL + +HRDLAARNVL+ + KI+DFGL++ + D YY + G+ Sbjct: 164 AYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLD-YYKETTNGRL 222 Query: 502 PLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECP 561 P+KW APE + R ++ +SDVWS+GV +WE + G PY + E+ +++G RM+ P Sbjct: 223 PVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKP 282 Query: 562 PECPPELYALMSDCWIYKWEDRPDF 586 C +LY +M +CW RP F Sbjct: 283 ANCTHDLYMIMRECWHAAPSQRPTF 307 >3PLS-A nrPDB Length = 298 Score = 158 bits (400), Expect = 6e-39, Method: Compositional matrix adjust. Identities = 90/252 (35%), Positives = 140/252 (55%), Gaps = 6/252 (2%) Query: 340 ADIELGCGNFGSVRQGVY-RMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYI 398 +D +G G+FG V G Y + +I AIK L + TE E +RE +M L++P + Sbjct: 25 SDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNV 84 Query: 399 VRLIGV-CQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 + LIG+ E L +++ G L +F+ + V ++ QV+ GM+YL E+ Sbjct: 85 LALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQK 144 Query: 457 FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSA--GKWPLKWYAPECINFR 514 FVHRDLAARN +L K++DFGL++ + D YY+ + + P+KW A E + Sbjct: 145 FVHRDLAARNCMLDESFTVKVADFGLARDI-LDREYYSVQQHRHARLPVKWTALESLQTY 203 Query: 515 KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSD 574 +F+++SDVWS+GV +WE L+ G PY+ + ++ F+ QG+R+ P CP LY +M Sbjct: 204 RFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQ 263 Query: 575 CWIYKWEDRPDF 586 CW RP F Sbjct: 264 CWEADPAVRPTF 275 >6FEX-A nrPDB Length = 321 Score = 157 bits (397), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 91/242 (37%), Positives = 137/242 (56%), Gaps = 22/242 (9%) Query: 366 VAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHK 424 VA+K+L+ K + ++E +IM +L +P I+RL+GVC Q + L ++ + G L++ Sbjct: 60 VAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQ 119 Query: 425 FLVGKREEI---------PVSNVAELLH---QVSMGMKYLEEKNFVHRDLAARNVLLVNR 472 FL + E P + LLH Q++ GM+YL NFVHRDLA RN L+ Sbjct: 120 FLSAHQLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGEN 179 Query: 473 HYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEA 532 KI+DFG+S+ L A D YY + P++W A ECI KF++ SDVW++GVT+WE Sbjct: 180 FTIKIADFGMSRNLYAGD-YYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEV 238 Query: 533 LSYGQ-KPYKKMKGPEVMA-----FIEQGKR--MECPPECPPELYALMSDCWIYKWEDRP 584 L + +P+ ++ +V+ F +QG++ + PP CP LY LM CW + E RP Sbjct: 239 LMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRP 298 Query: 585 DF 586 F Sbjct: 299 PF 300 >4XLV-A nrPDB Length = 328 Score = 156 bits (394), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 87/265 (32%), Positives = 140/265 (52%), Gaps = 14/265 (5%) Query: 343 ELGCGNFGSVRQGVYRMRKK---QIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIV 399 ELG G+FG V +G R K + VA+K + + + E + EA +M ++V Sbjct: 46 ELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVV 105 Query: 400 RLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEI------PVSNVAELLH---QVSMGM 449 RL+GV + + ++VME+ G L +L R E P + E++ +++ GM Sbjct: 106 RLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGM 165 Query: 450 KYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPE 509 YL K FVHRDLAARN ++ + KI DFG+++ + D YY G P++W APE Sbjct: 166 AYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETD-YYRKGGKGLLPVRWMAPE 224 Query: 510 CINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELY 569 + F++ SD+WS+GV +WE S ++PY+ + +V+ F+ G ++ P CP + Sbjct: 225 SLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVT 284 Query: 570 ALMSDCWIYKWEDRPDFLTVEQRMR 594 LM CW + RP FL + ++ Sbjct: 285 DLMRMCWQFNPNMRPTFLEIVNLLK 309 >4E20-A nrPDB Length = 290 Score = 155 bits (393), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 102/279 (36%), Positives = 142/279 (50%), Gaps = 23/279 (8%) Query: 327 DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADTEEMM 384 D +F KR I D LG G+FG V Y VA+K LK+G Sbjct: 1 DPTVFHKRYLKKIRD--LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQ 58 Query: 385 REAQIMHQLDNPYIVRLIGVCQAE---ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAEL 441 RE +I+ L + +IV+ G C+ + ++ LVME G L +L R + ++ + Sbjct: 59 REIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYL--PRHCVGLAQLLLF 116 Query: 442 LHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKW 501 Q+ GM YL ++++HR LAARNVLL N KI DFGL+KA+ YY R G Sbjct: 117 AQQICEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDS 176 Query: 502 PLKWYAPECINFRKFSSRSDVWSYGVTMWEALSY---GQKPYKK-----------MKGPE 547 P+ WYAPEC+ KF SDVWS+GVT++E L+Y Q P+ K M Sbjct: 177 PVFWYAPECLKECKFYYASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVLR 236 Query: 548 VMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586 + +E+G+R+ P CP E+Y LM +CW + RP F Sbjct: 237 LTELLERGERLPRPDRCPCEIYHLMKNCWETEASFRPTF 275 >6BSD-A nrPDB Length = 876 Score = 155 bits (392), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 91/248 (36%), Positives = 138/248 (55%), Gaps = 28/248 (11%) Query: 366 VAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHK 424 VA+K+L+ K + ++E +IM +L +P I+RL+GVC Q + L ++ + G L++ Sbjct: 615 VAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQ 674 Query: 425 FLV---------------GKREEIPVSNVAELLH---QVSMGMKYLEEKNFVHRDLAARN 466 FL G+ + P + LLH Q++ GM+YL NFVHRDLA RN Sbjct: 675 FLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRN 734 Query: 467 VLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYG 526 L+ KI+DFG+S+ L A D YY + P++W A ECI KF++ SDVW++G Sbjct: 735 CLVGENFTIKIADFGMSRNLYAGD-YYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFG 793 Query: 527 VTMWEALSYGQ-KPYKKMKGPEVMA-----FIEQGKR--MECPPECPPELYALMSDCWIY 578 VT+WE L + +P+ ++ +V+ F +QG++ + PP CP LY LM CW Sbjct: 794 VTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSR 853 Query: 579 KWEDRPDF 586 + E RP F Sbjct: 854 ESEQRPPF 861 >4OLI-A nrPDB Length = 645 Score = 155 bits (392), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 113/333 (33%), Positives = 157/333 (47%), Gaps = 39/333 (11%) Query: 283 RIDTLNSDGYTPEPA-----RITSPDKPRPMPMD-----TSVYESPYSDPEELKDKKLFL 332 ++ TL S T EP R D R P + T +SP SDP + L Sbjct: 298 QLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKK 357 Query: 333 KRDNLLIADIELGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADTEEMMREAQIM 390 RD LG G+FG V Y VA+K LK +E I+ Sbjct: 358 IRD--------LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDIL 409 Query: 391 HQLDNPYIVRLIGVCQAE---ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSM 447 L + +I++ G C+ + +L LVME G L +L R I ++ + Q+ Sbjct: 410 RTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYL--PRHSIGLAQLLLFAQQICE 467 Query: 448 GMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYA 507 GM YL ++++HR+LAARNVLL N KI DFGL+KA+ YY R G P+ WYA Sbjct: 468 GMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYA 527 Query: 508 PECINFRKFSSRSDVWSYGVTMWEALSY---GQKPYKK-----------MKGPEVMAFIE 553 PEC+ KF SDVWS+GVT++E L++ Q P K M + +E Sbjct: 528 PECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLE 587 Query: 554 QGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586 +G+R+ P +CP E+Y LM +CW + RP F Sbjct: 588 RGERLPRPDKCPCEVYHLMKNCWETEASFRPTF 620 Score = 88.2 bits (217), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 68/242 (28%), Positives = 110/242 (45%), Gaps = 20/242 (8%) Query: 358 RMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEM 416 R R +++ V +KVL A +M Q+ + ++ + GVC + ++V E Sbjct: 89 RDRGQELRVVLKVLDPSHHDIALA-FYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEY 147 Query: 417 AGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLV------ 470 GPL +L +R +P++ + Q++ + YLE KN VH ++ RN+LL Sbjct: 148 VEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAE 207 Query: 471 -NRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI--NFRKFSSRSDVWSYGV 527 + K+SD G+ LGA +R + W APEC+ S+ D W +G Sbjct: 208 GTSPFIKLSDPGV--GLGA-----LSREERVERIPWLAPECLPGGANSLSTAMDKWGFGA 260 Query: 528 TMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFL 587 T+ E G+ P + E F ++ R+ P C P+L L S C Y+ RP F Sbjct: 261 TLLEICFDGEAPLQSRSPSEKEHFYQRQHRLP-EPSC-PQLATLTSQCLTYEPTQRPSFR 318 Query: 588 TV 589 T+ Sbjct: 319 TI 320 >6GQK-A nrPDB Length = 328 Score = 154 bits (390), Expect = 8e-38, Method: Compositional matrix adjust. Identities = 100/297 (33%), Positives = 147/297 (49%), Gaps = 24/297 (8%) Query: 319 YSDPEELK-DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQ---IDVAIKVLKQG 374 Y DP +L D K R+ L LG G FG V + + K + VA+K+LK Sbjct: 24 YIDPTQLPYDHKWEFPRNRLSFGKT-LGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPS 82 Query: 375 TEKADTEEMMREAQIMHQLDN-PYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREE 432 + E +M E +++ L N IV L+G C +++ E G L FL KR+E Sbjct: 83 AHSTEREALMSELKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDE 142 Query: 433 ---------------IPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKI 477 + + ++ +QV+ GM +L KN +HRDLAARN+LL + + KI Sbjct: 143 FVPYKVAPEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKI 202 Query: 478 SDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQ 537 DFGL++ + +DS Y + + P+KW APE I ++ SDVWSYG+ +WE S G Sbjct: 203 CDFGLARDI-KNDSNYVDKGNARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGS 261 Query: 538 KPYKKMK-GPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRM 593 PY M + I++G RM P P E+Y +M CW + RP F + Q + Sbjct: 262 SPYPGMPVDSKFYKMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQIVQDI 318 >6DBM-A nrPDB Length = 318 Score = 154 bits (389), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 102/279 (36%), Positives = 140/279 (50%), Gaps = 23/279 (8%) Query: 327 DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADTEEMM 384 D +F KR I D LG G+FG V Y VA+K LK Sbjct: 24 DPTVFHKRYLKKIRD--LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWK 81 Query: 385 REAQIMHQLDNPYIVRLIGVCQ---AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAEL 441 +E I+ L + +I++ G C+ A +L LVME G L +L R I ++ + Sbjct: 82 QEIDILRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYL--PRHSIGLAQLLLF 139 Query: 442 LHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKW 501 Q+ GM YL ++++HRDLAARNVLL N KI DFGL+KA+ YY R G Sbjct: 140 AQQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDS 199 Query: 502 PLKWYAPECINFRKFSSRSDVWSYGVTMWEALSY---GQKPYKK-----------MKGPE 547 P+ WYAPEC+ KF SDVWS+GVT++E L++ Q P K M Sbjct: 200 PVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLR 259 Query: 548 VMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586 + +E+G+R+ P +CP E+Y LM +CW + RP F Sbjct: 260 LTELLERGERLPRPDKCPAEVYHLMKNCWETEASFRPTF 298 >3KRL-A nrPDB Length = 335 Score = 154 bits (389), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 98/293 (33%), Positives = 147/293 (50%), Gaps = 24/293 (8%) Query: 319 YSDPEELK-DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQ---IDVAIKVLKQG 374 + DP +L ++K R+NL LG G FG V + K+ + VA+K+LK Sbjct: 29 FIDPTQLPYNEKWEFPRNNLQFGKT-LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKST 87 Query: 375 TEKADTEEMMREAQIMHQL-DNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKR-- 430 + E +M E +IM L + IV L+G C ++++ E G L FL KR Sbjct: 88 AHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPP 147 Query: 431 -------------EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKI 477 E++ ++ QV+ GM +L KN +HRD+AARNVLL N H AKI Sbjct: 148 GLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKI 207 Query: 478 SDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQ 537 DFGL++ + +DS Y + + P+KW APE I ++ +SDVWSYG+ +WE S G Sbjct: 208 GDFGLARDI-MNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGL 266 Query: 538 KPYKK-MKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTV 589 PY + + ++ G +M P P +Y++M CW + RP F + Sbjct: 267 NPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 319 >3BEA-A nrPDB Length = 333 Score = 154 bits (389), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 102/288 (35%), Positives = 148/288 (51%), Gaps = 22/288 (7%) Query: 319 YSDPEEL-KDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQ---IDVAIKVLKQG 374 + DP +L ++K R+NL LG G FG V + K+ + VA+K+LK Sbjct: 29 FIDPTQLPYNEKWEFPRNNLQFGKT-LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKST 87 Query: 375 TEKADTEEMMREAQIMHQL-DNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKR-- 430 + E +M E +IM L + IV L+G C ++++ E G L FL K Sbjct: 88 AHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRV 147 Query: 431 -EEIPVSNVA-------ELLH---QVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISD 479 E P +A +LLH QV+ GM +L KN +HRD+AARNVLL N H AKI D Sbjct: 148 LETDPAFAIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGD 207 Query: 480 FGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKP 539 FGL++ + +DS Y + + P+KW APE I ++ +SDVWSYG+ +WE S G P Sbjct: 208 FGLARDI-MNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNP 266 Query: 540 YKK-MKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586 Y + + ++ G +M P P +Y++M CW + RP F Sbjct: 267 YPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTF 314 >2OGV-A nrPDB Length = 317 Score = 154 bits (388), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 100/287 (34%), Positives = 149/287 (51%), Gaps = 18/287 (6%) Query: 319 YSDPEEL-KDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQ---IDVAIKVLKQG 374 + DP +L ++K R+NL LG G FG V + K+ + VA+K+LK Sbjct: 21 FIDPTQLPYNEKWEFPRNNLQFGKT-LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKST 79 Query: 375 TEKADTEEMMREAQIMHQL-DNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGK--- 429 + E +M E +IM L + IV L+G C ++++ E G L FL K Sbjct: 80 AHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEA 139 Query: 430 ---REEIPVSNVAELLH---QVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLS 483 +E+ + +LLH QV+ GM +L KN +HRD+AARNVLL N H AKI DFGL+ Sbjct: 140 DLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLA 199 Query: 484 KALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKK- 542 + + +DS Y + + P+KW APE I ++ +SDVWSYG+ +WE S G PY Sbjct: 200 RDI-MNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGI 258 Query: 543 MKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTV 589 + + ++ G +M P P +Y++M CW + RP F + Sbjct: 259 LVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 305 >6FER-A nrPDB Length = 309 Score = 152 bits (385), Expect = 4e-37, Method: Compositional matrix adjust. Identities = 95/284 (33%), Positives = 150/284 (52%), Gaps = 37/284 (13%) Query: 337 LLIADIELGCGNFGSVR----QGVYRMRKKQ----------IDVAIKVLKQGTEKADTEE 382 LL +LG G FG V +G+ + + K + VA+K+L+ K + Sbjct: 10 LLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARND 69 Query: 383 MMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVS----- 436 ++E +IM +L +P I+ L+ VC + L ++ E G L++FL R E P S Sbjct: 70 FLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFL--SRHEPPNSSSSDV 127 Query: 437 ------NVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADD 490 N+ + Q++ GMKYL NFVHRDLA RN L+ + KI+DFG+S+ L + D Sbjct: 128 RTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGD 187 Query: 491 SYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQ-KPYKKMKGPEVM 549 YY + P++W + E I KF++ SDVW++GVT+WE ++ Q +PY ++ +V+ Sbjct: 188 -YYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVI 246 Query: 550 A-----FIEQGKR--MECPPECPPELYALMSDCWIYKWEDRPDF 586 F +QG++ + P CP +Y LM CW ++RP F Sbjct: 247 ENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSF 290 >4R7H-A nrPDB Length = 343 Score = 152 bits (384), Expect = 4e-37, Method: Compositional matrix adjust. Identities = 100/300 (33%), Positives = 150/300 (50%), Gaps = 31/300 (10%) Query: 319 YSDPEELK-DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQ---IDVAIKVLKQG 374 + DP +L ++K R+NL LG G FG V + K+ + VA+K+LK Sbjct: 33 FIDPTQLPYNEKWEFPRNNLQFGKT-LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKST 91 Query: 375 TEKADTEEMMREAQIMHQL-DNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREE 432 + E +M E +IM L + IV L+G C ++++ E G L FL K E Sbjct: 92 AHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEA 151 Query: 433 IPVSNVA-------------------ELLH---QVSMGMKYLEEKNFVHRDLAARNVLLV 470 + +++ +LLH QV+ GM +L KN +HRD+AARNVLL Sbjct: 152 MLGPSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLT 211 Query: 471 NRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMW 530 N H AKI DFGL++ + +DS Y + + P+KW APE I ++ +SDVWSYG+ +W Sbjct: 212 NGHVAKIGDFGLARDI-MNDSNYIVKGNARLPVKWMAPESIFDSVYTVQSDVWSYGILLW 270 Query: 531 EALSYGQKPYKK-MKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTV 589 E S G PY + + ++ G +M P P +Y++M CW + RP F + Sbjct: 271 EIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 330 >5X02-A nrPDB Length = 347 Score = 152 bits (383), Expect = 5e-37, Method: Compositional matrix adjust. Identities = 104/300 (34%), Positives = 150/300 (50%), Gaps = 31/300 (10%) Query: 316 ESPYSDPEELK-DKKLFLKRDNLLIADIELGCGNFGSVRQGV-YRMRKK--QIDVAIKVL 371 E Y D E + D K R+NL + LG G FG V Y + K I VA+K+L Sbjct: 28 EYFYVDFREYEYDLKWEFPRENLEFGKV-LGSGAFGKVMNATAYGISKTGVSIQVAVKML 86 Query: 372 KQGTEKADTEEMMREAQIMHQL-DNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGK 429 K+ + ++ E +M E ++M QL + IV L+G C + L+ E G L +L K Sbjct: 87 KEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSK 146 Query: 430 RE-------------------EIPVSNVAELL---HQVSMGMKYLEEKNFVHRDLAARNV 467 RE ++ V +LL +QV+ GM++LE K+ VHRDLAARNV Sbjct: 147 REKFSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNV 206 Query: 468 LLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGV 527 L+ + KI DFGL++ + DS Y R + P+KW APE + ++ +SDVWSYG+ Sbjct: 207 LVTHGKVVKICDFGLARDI-MSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGI 265 Query: 528 TMWEALSYGQKPYKKM-KGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586 +WE S G PY + I+ G +M+ P E+Y +M CW + RP F Sbjct: 266 LLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSF 325 >5GRN-A nrPDB Length = 356 Score = 151 bits (382), Expect = 7e-37, Method: Compositional matrix adjust. Identities = 109/305 (35%), Positives = 154/305 (50%), Gaps = 36/305 (11%) Query: 315 YESPYSDPEEL-KDKKLFLKRDNLLIADIELGCGNFGSVRQGV-YRMRKKQ--IDVAIKV 370 +E Y DP +L D + RD L++ + LG G FG V +G Y + + Q + VA+K+ Sbjct: 25 HEYIYVDPMQLPYDSRWEFPRDGLVLGRV-LGSGAFGKVVEGTAYGLSRSQPVMKVAVKM 83 Query: 371 LKQGTEKADTEEMMREAQIMHQLDNPY--IVRLIGVCQAEA-LMLVMEMAGGGPL----H 423 LK ++ + +M E +IM L P+ IV L+G C + ++ E G L H Sbjct: 84 LKPTARSSEKQALMSELKIMTHL-GPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLH 142 Query: 424 K----FLVGKREEIPVSNVAELL-----------------HQVSMGMKYLEEKNFVHRDL 462 K FL K++ + S V LL +QV+ GM++L KN VHRDL Sbjct: 143 KNRDSFLSHKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDL 202 Query: 463 AARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDV 522 AARNVLL KI DFGL++ + DS Y ++ + P+KW APE I +++ SDV Sbjct: 203 AARNVLLAQGKIVKICDFGLARDI-MHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDV 261 Query: 523 WSYGVTMWEALSYGQKPYKKMKGPEVMAF-IEQGKRMECPPECPPELYALMSDCWIYKWE 581 WSYG+ +WE S G PY M I+ G RM P E+Y +M CW + E Sbjct: 262 WSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPE 321 Query: 582 DRPDF 586 RP F Sbjct: 322 KRPSF 326 >4XUF-A nrPDB Length = 297 Score = 151 bits (382), Expect = 7e-37, Method: Compositional matrix adjust. Identities = 100/288 (34%), Positives = 145/288 (50%), Gaps = 30/288 (10%) Query: 327 DKKLFLKRDNLLIADIELGCGNFGSVRQGV-YRMRKK--QIDVAIKVLKQGTEKADTEEM 383 D K R+NL + LG G FG V Y + K I VA+K+LK+ + ++ E + Sbjct: 1 DLKWEFPRENLEFGKV-LGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREAL 59 Query: 384 MREAQIMHQL-DNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKRE---------- 431 M E ++M QL + IV L+G C + L+ E G L +L KRE Sbjct: 60 MSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYE 119 Query: 432 ---------EIPVSNVAELL---HQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISD 479 ++ V +LL +QV+ GM++LE K+ VHRDLAARNVL+ + KI D Sbjct: 120 NQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICD 179 Query: 480 FGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKP 539 FGL++ + DS Y R + P+KW APE + ++ +SDVWSYG+ +WE S G P Sbjct: 180 FGLARDI-MSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNP 238 Query: 540 YKKM-KGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586 Y + I+ G +M+ P E+Y +M CW + RP F Sbjct: 239 YPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSF 286 >3G0E-A nrPDB Length = 336 Score = 149 bits (377), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 103/297 (34%), Positives = 143/297 (48%), Gaps = 26/297 (8%) Query: 319 YSDPEELK-DKKLFLKRDNLLIADIELGCGNFGSVRQGV-YRMRKKQ--IDVAIKVLKQG 374 Y DP +L D K R+ L LG G FG V + Y + K + VA+K+LK Sbjct: 29 YIDPTQLPYDHKWEFPRNRLSFGK-TLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPS 87 Query: 375 TEKADTEEMMREAQIMHQLDNPY-IVRLIGVCQAEALMLVM-EMAGGGPLHKFLVGKREE 432 + E +M E +++ L N IV L+G C LV+ E G L FL KR+ Sbjct: 88 AHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDS 147 Query: 433 IPVSNVAELL-----------------HQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYA 475 S + + +QV+ GM +L KN +HRDLAARN+LL + Sbjct: 148 FICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRIT 207 Query: 476 KISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSY 535 KI DFGL++ + +DS Y + + P+KW APE I ++ SDVWSYG+ +WE S Sbjct: 208 KICDFGLARDI-KNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSL 266 Query: 536 GQKPYKKM-KGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQ 591 G PY M + I++G RM P P E+Y +M CW RP F + Q Sbjct: 267 GSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 323 >3CJF-A nrPDB Length = 309 Score = 149 bits (376), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 104/303 (34%), Positives = 153/303 (50%), Gaps = 32/303 (10%) Query: 305 PRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQG-VYRMRKKQ 363 P +P+D PY K RD L + LG G FG V + + + K Sbjct: 3 PDELPLDEHCERLPYDA------SKWEFPRDRLNLGK-PLGRGAFGQVIEADAFGIDKTA 55 Query: 364 I--DVAIKVLKQGTEKADTEEMMREAQIM----HQLDNPYIVRLIGVCQAEA--LMLVME 415 VA+K+LK+G ++ +M E +I+ H L+ +V L+G C LM+++E Sbjct: 56 TCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLN---VVNLLGACTKPGGPLMVIVE 112 Query: 416 MAGGGPLHKFLVGKREE-IPVSNVAE----LLH------QVSMGMKYLEEKNFVHRDLAA 464 G L +L KR E +P ++ + L H QV+ GM++L + +HRDLAA Sbjct: 113 FCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAA 172 Query: 465 RNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWS 524 RN+LL ++ KI DFGL++ + D Y + + PLKW APE I R ++ +SDVWS Sbjct: 173 RNILLSEKNVVKICDFGLARDIYKDPDY-VRKGDARLPLKWMAPETIFDRVYTIQSDVWS 231 Query: 525 YGVTMWEALSYGQKPYKKMK-GPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDR 583 +GV +WE S G PY +K E +++G RM P PE+Y M DCW + R Sbjct: 232 FGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQR 291 Query: 584 PDF 586 P F Sbjct: 292 PTF 294 >4UYA-A nrPDB Length = 340 Score = 137 bits (346), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 95/268 (35%), Positives = 137/268 (51%), Gaps = 28/268 (10%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEK---ADTEEMMREAQIMHQLDNPYIVR 400 +G G FG V YR + +VA+K +Q E+ A E + REA++ L +P I+ Sbjct: 34 IGAGGFGQV----YRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIE 89 Query: 401 LIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV- 458 L GVC Q L LV+E A GG L++ L G+R IP + Q++ GM YL E+ FV Sbjct: 90 LRGVCLQQPHLCLVLEFARGGALNRALAGRR--IPPHVLVNWAVQIARGMLYLHEEAFVP 147 Query: 459 --HRDLAARNVLLVNR--------HYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 HRDL + N+LL+ + KI+DFGL++ + + T + A W AP Sbjct: 148 ILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAR-----EWHRTTKMATAGAYAWMAP 202 Query: 509 ECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK-RMECPPECPPE 567 E I FS SD+WSYGV +WE L+ G+ PY+ + G V + K + P CP Sbjct: 203 EVIKSSLFSKGSDIWSYGVLLWELLT-GEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEP 261 Query: 568 LYALMSDCWIYKWEDRPDFLTVEQRMRA 595 LM +CW RP F + +++ A Sbjct: 262 FAKLMKECWQQDPHIRPSFALILEQLTA 289 >3PPZ-A nrPDB Length = 309 Score = 131 bits (330), Expect = 7e-31, Method: Compositional matrix adjust. Identities = 86/264 (32%), Positives = 144/264 (54%), Gaps = 15/264 (5%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKAD-TEEMMREAQIMHQLDNPYIVRL 401 ++G G+FG+V +R DVA+K+L + A+ E +RE IM +L +P IV Sbjct: 44 KIGAGSFGTV----HRAEWHGSDVAVKILMEQDFHAERVNEFLREVAIMKRLRHPNIVLF 99 Query: 402 IG-VCQAEALMLVMEMAGGGPLHKFL--VGKREEIPVSNVAELLHQVSMGMKYLEEKN-- 456 +G V Q L +V E G L++ L G RE++ + + V+ GM YL +N Sbjct: 100 MGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPP 159 Query: 457 FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKF 516 VHRDL + N+L+ ++ K+ DFGLS+ + ++ +++SA P +W APE + Sbjct: 160 IVHRDLKSPNLLVDKKYTVKVCDFGLSRLKAS--TFLSSKSAAGTP-EWMAPEVLRDEPS 216 Query: 517 SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIE-QGKRMECPPECPPELYALMSDC 575 + +SDV+S+GV +WE L+ Q+P+ + +V+A + + KR+E P P++ A++ C Sbjct: 217 NEKSDVYSFGVILWE-LATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAAIIEGC 275 Query: 576 WIYKWEDRPDFLTVEQRMRACYYS 599 W + RP F T+ +R S Sbjct: 276 WTNEPWKRPSFATIMDLLRPLIKS 299 >3DTC-A nrPDB Length = 271 Score = 131 bits (330), Expect = 8e-31, Method: Compositional matrix adjust. Identities = 90/266 (33%), Positives = 132/266 (49%), Gaps = 28/266 (10%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEK---ADTEEMMREAQIMHQLDNPYIVR 400 +G G FG V YR +VA+K + ++ E + +EA++ L +P I+ Sbjct: 15 IGIGGFGKV----YRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIA 70 Query: 401 LIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV- 458 L GVC E L LVME A GGPL++ L GKR IP + Q++ GM YL ++ V Sbjct: 71 LRGVCLKEPNLCLVMEFARGGPLNRVLSGKR--IPPDILVNWAVQIARGMNYLHDEAIVP 128 Query: 459 --HRDLAARNVLLVNR--------HYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 HRDL + N+L++ + KI+DFGL++ + + T + + W AP Sbjct: 129 IIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR-----EWHRTTKMSAAGAYAWMAP 183 Query: 509 ECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK-RMECPPECPPE 567 E I FS SDVWSYGV +WE L+ G+ P++ + G V + K + P CP Sbjct: 184 EVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEP 242 Query: 568 LYALMSDCWIYKWEDRPDFLTVEQRM 593 LM DCW RP F + ++ Sbjct: 243 FAKLMEDCWNPDPHSRPSFTNILDQL 268 >4UY9-A nrPDB Length = 323 Score = 130 bits (328), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 90/266 (33%), Positives = 132/266 (49%), Gaps = 28/266 (10%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEK---ADTEEMMREAQIMHQLDNPYIVR 400 +G G FG V YR +VA+K + ++ E + +EA++ L +P I+ Sbjct: 17 IGIGGFGKV----YRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIA 72 Query: 401 LIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV- 458 L GVC E L LVME A GGPL++ L GKR IP + Q++ GM YL ++ V Sbjct: 73 LRGVCLKEPNLCLVMEFARGGPLNRVLSGKR--IPPDILVNWAVQIARGMNYLHDEAIVP 130 Query: 459 --HRDLAARNVLLVNR--------HYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 HRDL + N+L++ + KI+DFGL++ + + T + + W AP Sbjct: 131 IIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR-----EWHRTTKMSAAGTYAWMAP 185 Query: 509 ECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK-RMECPPECPPE 567 E I FS SDVWSYGV +WE L+ G+ P++ + G V + K + P CP Sbjct: 186 EVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEP 244 Query: 568 LYALMSDCWIYKWEDRPDFLTVEQRM 593 LM DCW RP F + ++ Sbjct: 245 FAKLMEDCWNPDPHSRPSFTNILDQL 270 >3HNG-A nrPDB Length = 360 Score = 124 bits (310), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 62/165 (37%), Positives = 97/165 (58%), Gaps = 2/165 (1%) Query: 430 REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD 489 +E I + ++ QV+ GM++L + +HRDLAARN+LL + KI DFGL++ + + Sbjct: 193 KEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKN 252 Query: 490 DSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPE-V 548 Y + + PLKW APE I + +S++SDVWSYGV +WE S G PY ++ E Sbjct: 253 PDY-VRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDF 311 Query: 549 MAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRM 593 + + +G RM P PE+Y +M DCW ++RP F + +++ Sbjct: 312 CSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL 356 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 40/143 (27%), Positives = 67/143 (46%), Gaps = 13/143 (9%) Query: 305 PRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQG-VYRMRKKQ 363 P +P+D PY K R+ L + LG G FG V Q + ++K Sbjct: 3 PDEVPLDEQCERLPYDA------SKWEFARERLKLGK-SLGRGAFGKVVQASAFGIKKSP 55 Query: 364 I--DVAIKVLKQGTEKADTEEMMREAQIMHQLDNPY-IVRLIGVC--QAEALMLVMEMAG 418 VA+K+LK+G ++ + +M E +I+ + + +V L+G C Q LM+++E Sbjct: 56 TCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCK 115 Query: 419 GGPLHKFLVGKREEIPVSNVAEL 441 G L +L KR+ ++ A L Sbjct: 116 YGNLSNYLKSKRDLFFLNKDAAL 138 >3VHK-A nrPDB Length = 368 Score = 121 bits (304), Expect = 8e-28, Method: Compositional matrix adjust. Identities = 61/144 (42%), Positives = 85/144 (59%), Gaps = 2/144 (1%) Query: 444 QVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPL 503 QV+ GM++L + +HRDLAARN+LL ++ KI DFGL++ + D Y + + PL Sbjct: 208 QVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDY-VRKGDARLPL 266 Query: 504 KWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMK-GPEVMAFIEQGKRMECPP 562 KW APE I R ++ +SDVWS+GV +WE S G PY +K E +++G RM P Sbjct: 267 KWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPD 326 Query: 563 ECPPELYALMSDCWIYKWEDRPDF 586 PE+Y M DCW + RP F Sbjct: 327 YTTPEMYQTMLDCWHGEPSQRPTF 350 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 39/135 (28%), Positives = 60/135 (44%), Gaps = 13/135 (9%) Query: 305 PRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQG-VYRMRKKQ 363 P +P+D PY K RD L + LG G FG V + + + K Sbjct: 5 PDELPLDEHCERLPYDA------SKWEFPRDRLKLGK-PLGRGAFGQVIEADAFGIDKTA 57 Query: 364 I--DVAIKVLKQGTEKADTEEMMREAQIM-HQLDNPYIVRLIGVCQAEA--LMLVMEMAG 418 VA+K+LK+G ++ +M E +I+ H + +V L+G C LM+++E Sbjct: 58 TCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCK 117 Query: 419 GGPLHKFLVGKREEI 433 G L +L KR E Sbjct: 118 FGNLSTYLRSKRNEF 132 >4RT7-A nrPDB Length = 415 Score = 120 bits (301), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 63/162 (38%), Positives = 92/162 (56%), Gaps = 5/162 (3%) Query: 429 KREEIPVSNVAELL---HQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKA 485 + E++ V +LL +QV+ GM++LE K+ VHRDLAARNVL+ + KI DFGL++ Sbjct: 233 EEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARD 292 Query: 486 LGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKM-K 544 + DS Y R + P+KW APE + ++ +SDVWSYG+ +WE S G PY + Sbjct: 293 I-MSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPV 351 Query: 545 GPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586 I+ G +M+ P E+Y +M CW + RP F Sbjct: 352 DANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSF 393 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 42/124 (33%), Positives = 61/124 (49%), Gaps = 7/124 (5%) Query: 316 ESPYSDPEELK-DKKLFLKRDNLLIADIELGCGNFGSVRQGV-YRMRKK--QIDVAIKVL 371 E Y D E + D K R+NL + LG G FG V Y + K I VA+K+L Sbjct: 45 EYFYVDFREYEYDLKWEFPRENLEFGKV-LGSGAFGKVMNATAYGISKTGVSIQVAVKML 103 Query: 372 KQGTEKADTEEMMREAQIMHQL-DNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGK 429 K+ + ++ E +M E ++M QL + IV L+G C + L+ E G L +L K Sbjct: 104 KEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSK 163 Query: 430 REEI 433 RE+ Sbjct: 164 REKF 167 >5VO2-A nrPDB Length = 300 Score = 107 bits (267), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 78/242 (32%), Positives = 114/242 (47%), Gaps = 21/242 (8%) Query: 350 GSVRQG-VYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMH--QLDNPYIVRLIGVC- 405 GS QG V+ R +VA+K ++ ++E I H +L +P I+ GVC Sbjct: 21 GSGAQGAVFLGRFHGEEVAVKKVRD----------LKETDIKHLRKLKHPNIITFKGVCT 70 Query: 406 QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAAR 465 QA ++ME G L++ L R P S + + ++ GM YL +HRDL + Sbjct: 71 QAPCYCILMEFCAQGQLYEVLRAGRPVTP-SLLVDWSMGIAGGMNYLHLHKIIHRDLKSP 129 Query: 466 NVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSY 525 N+L+ KISDFG SK L D AG + W APE I S + D+WS+ Sbjct: 130 NMLITYDDVVKISDFGTSKELS--DKSTKMSFAGT--VAWMAPEVIRNEPVSEKVDIWSF 185 Query: 526 GVTMWEALSYGQKPYKKMKGPEVMAFI-EQGKRMECPPECPPELYALMSDCWIYKWEDRP 584 GV +WE L+ G+ PYK + ++ + + P CP L+ CW K +RP Sbjct: 186 GVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRP 244 Query: 585 DF 586 F Sbjct: 245 SF 246 >6FDY-U nrPDB Length = 276 Score = 105 bits (262), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 66/222 (29%), Positives = 121/222 (54%), Gaps = 11/222 (4%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIK-VLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 LG G + +V + + +++ VAIK V K+ KA E ++ E +I+ + +P+IV+L Sbjct: 19 LGSGTYATVYKAYAKKDTREV-VAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLK 77 Query: 403 GV-CQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 ++ + L+ME GG L +F + R +P + Q++ +++L E+N H D Sbjct: 78 DFQWDSDNIYLIMEFCAGGDLSRF-IHTRRILPEKVARVFMQQLASALQFLHERNISHLD 136 Query: 462 LAARNVLL--VNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 519 L +N+LL + + + K++DFG ++ + D + R + PL + APE + R++ +R Sbjct: 137 LKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGS---PL-YMAPEMVCQRQYDAR 192 Query: 520 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECP 561 D+WS GV ++EAL +GQ P+ E+ I + +E P Sbjct: 193 VDLWSMGVILYEAL-FGQPPFASRSFSELEEKIRSNRVIELP 233 >4F0G-A nrPDB Length = 287 Score = 105 bits (261), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 83/271 (30%), Positives = 138/271 (50%), Gaps = 30/271 (11%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTE------EMMREAQ 388 DN + + ++G G FG V +G R+ K + VAIK L G + +TE E RE Sbjct: 18 DNEIEYEKQIGKGGFGLVHKG--RLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVF 75 Query: 389 IMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMG 448 IM L++P IV+L G+ M VME G L+ L+ K I S L+ +++G Sbjct: 76 IMSNLNHPNIVKLYGLMHNPPRM-VMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLDIALG 134 Query: 449 MKYLEEKN--FVHRDLAARNVLLVNRHY-----AKISDFGLSKALGADDSYYTARSAGKW 501 ++Y++ +N VHRDL + N+ L + AK++DFGLS+ + + G + Sbjct: 135 IEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQ----QSVHSVSGLLGNF 190 Query: 502 PLKWYAPECINFRK--FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI----EQG 555 +W APE I + ++ ++D +S+ + ++ L+ G+ P+ + ++ FI E+G Sbjct: 191 --QWMAPETIGAEEESYTEKADTYSFAMILYTILT-GEGPFDEYSYGKI-KFINMIREEG 246 Query: 556 KRMECPPECPPELYALMSDCWIYKWEDRPDF 586 R P +CPP L ++ CW + RP F Sbjct: 247 LRPTIPEDCPPRLRNVIELCWSGDPKKRPHF 277 >5USZ-A nrPDB Length = 289 Score = 103 bits (256), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 76/279 (27%), Positives = 130/279 (46%), Gaps = 25/279 (8%) Query: 334 RDNLLIADIELGCGNFGSVRQGVYRM-----RKKQIDVAIKVLKQGTEKADTEEMMREAQ 388 R+ LI + LG G F + +GV R + + +V +KVL + + +E A Sbjct: 6 RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKA-HRNYSESFFEAAS 64 Query: 389 IMHQLDNPYIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSM 447 +M +L + ++V GVC + +LV E G L +L + I + E+ Q++ Sbjct: 65 MMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAA 124 Query: 448 GMKYLEEKNFVHRDLAARNVLLV--------NRHYAKISDFGLSKALGADDSYYTARSAG 499 M +LEE +H ++ A+N+LL+ N + K+SD G+S + D Sbjct: 125 AMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQER---- 180 Query: 500 KWPLKWYAPECI-NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM 558 + W PECI N + + +D WS+G T+WE S G KP + + F E R Sbjct: 181 ---IPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYED--RH 235 Query: 559 ECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACY 597 + P EL L+++C Y+ + RP F + + + + + Sbjct: 236 QLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLF 274 >4YFF-A nrPDB Length = 311 Score = 102 bits (254), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 79/275 (28%), Positives = 137/275 (49%), Gaps = 23/275 (8%) Query: 336 NLLIADIE----LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQI 389 +L +++IE +G G+FG V +G R R K VAIK + T K+D + RE I Sbjct: 38 HLQLSEIEFHEIIGSGSFGKVYKG--RCRNKI--VAIKRYRANTYCSKSDVDMFCREVSI 93 Query: 390 MHQLDNPYIVRLIGVCQAE--ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSM 447 + QL++P +++ +G C + +V + GG L L ++ + + + + V+ Sbjct: 94 LCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAK 153 Query: 448 GMKYLEE--KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKW 505 GM+YL + +HRDL + N+LL +A ++DFG S+ L + D + G L+W Sbjct: 154 GMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGN--LRW 211 Query: 506 YAPECIN-FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPP-- 562 APE +++ ++DV+SY + +WE L+ G+ P+ +K A + PP Sbjct: 212 MAPEVFTQCTRYTIKADVFSYALCLWEILT-GEIPFAHLK--PAAAAADMAYHHIRPPIG 268 Query: 563 -ECPPELYALMSDCWIYKWEDRPDFLTVEQRMRAC 596 P + +L+ W E RP+F V ++ C Sbjct: 269 YSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEEC 303 >5X5O-A nrPDB Length = 310 Score = 102 bits (254), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 77/249 (30%), Positives = 124/249 (49%), Gaps = 25/249 (10%) Query: 345 GCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGV 404 G G+FGSV + + + K++ V K+LK + +EA+I+ L + I++ GV Sbjct: 24 GGGSFGSVYRAKWISQDKEVAVK-KLLK----------IEKEAEILSVLSHRNIIQFYGV 72 Query: 405 C-QAEALMLVMEMAGGGPLHKFLVGKR-EEIPVSNVAELLHQVSMGMKYLEEK---NFVH 459 + +V E A G L+ ++ R EE+ + ++ V+ GM YL + +H Sbjct: 73 ILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIH 132 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARS-AGKWPLKWYAPECINFRKFSS 518 RDL +RNV++ KI DFG S+ ++ T S G +P W APE I S Sbjct: 133 RDLKSRNVVIAADGVLKICDFGASRF----HNHTTHMSLVGTFP--WMAPEVIQSLPVSE 186 Query: 519 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAF-IEQGKRMECPPECPPELYALMSDCWI 577 D +SYGV +WE L+ + P+K ++G +V +E+ +R+ P CP L+ CW Sbjct: 187 TCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWE 245 Query: 578 YKWEDRPDF 586 + RP F Sbjct: 246 ADAKKRPSF 254 >3OMV-A nrPDB Length = 307 Score = 100 bits (250), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 74/276 (26%), Positives = 131/276 (47%), Gaps = 24/276 (8%) Query: 338 LIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMR-EAQIMHQLDNP 396 ++ +G G+FG+V +G K DVA+K+LK + + R E ++ + + Sbjct: 38 VMLSTRIGSGSFGTVYKG-----KWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHV 92 Query: 397 YIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 I+ +G + L +V + G L+K L + + + + ++ Q + GM YL KN Sbjct: 93 NILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKN 152 Query: 457 FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWP---LKWYAPECINF 513 +HRD+ + N+ L KI DFGL+ S ++ + P + W APE I Sbjct: 153 IIHRDMKSNNIFLHEGLTVKIGDFGLATV----KSRWSGSQQVEQPTGSVLWMAPEVIRM 208 Query: 514 RK---FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECP------PEC 564 + FS +SDV+SYG+ ++E ++ G+ PY + + + F+ G+ P C Sbjct: 209 QDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMV-GRGYASPDLSKLYKNC 266 Query: 565 PPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL 600 P + L++DC E+RP F + + +SL Sbjct: 267 PKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSL 302 >5HVK-A nrPDB Length = 315 Score = 100 bits (249), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 71/284 (25%), Positives = 124/284 (43%), Gaps = 24/284 (8%) Query: 338 LIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPY 397 LI LG G FG + +R ++ V ++++ E T ++E ++M L++P Sbjct: 16 LIHGEVLGKGCFGQAIKVTHR-ETGEVMVMKELIRFDEETQRT--FLKEVKVMRCLEHPN 72 Query: 398 IVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 +++ IGV + + L + E GG L + + P S ++ GM YL N Sbjct: 73 VLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMN 132 Query: 457 FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLK-----------W 505 +HR+L + N L+ ++DFGL++ + + + + K P + W Sbjct: 133 IIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYW 192 Query: 506 YAPECINFRKFSSRSDVWSYGVTMWEALSYGQK-----PYKKMKGPEVMAFIEQGKRMEC 560 APE IN R + + DV+S+G+ + E + P G V F+++ C Sbjct: 193 MAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDR----YC 248 Query: 561 PPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKV 604 PP CPP + + C E RP F+ +E + LA + Sbjct: 249 PPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHLAGHL 292 >4GS6-A nrPDB Length = 315 Score = 100 bits (248), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 79/259 (30%), Positives = 126/259 (48%), Gaps = 25/259 (9%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G G FG V + +R + DVAIK ++ +E+ + + E + + ++++P IV+L G Sbjct: 17 VGRGAFGVVCKAKWRAK----DVAIKQIESESER---KAFIVELRQLSRVNHPNIVKLYG 69 Query: 404 VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLH---QVSMGMKYL---EEKNF 457 C + LVME A GG L+ L G E +P A + Q S G+ YL + K Sbjct: 70 AC-LNPVCLVMEYAEGGSLYNVLHGA-EPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKAL 127 Query: 458 VHRDLAARNVLLV-NRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKF 516 +HRDL N+LLV KI DFG + D + + G W APE + Sbjct: 128 IHRDLKPPNLLLVAGGTVLKICDFGTA----CDIQTHMTNNKGS--AAWMAPEVFEGSNY 181 Query: 517 SSRSDVWSYGVTMWEALSYGQKPYKKMKGP--EVMAFIEQGKRMECPPECPPELYALMSD 574 S + DV+S+G+ +WE ++ +KP+ ++ GP +M + G R P + +LM+ Sbjct: 182 SEKCDVFSWGIILWEVITR-RKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTR 240 Query: 575 CWIYKWEDRPDFLTVEQRM 593 CW RP + + M Sbjct: 241 CWSKDPSQRPSMEEIVKIM 259 >2XIK-A nrPDB Length = 294 Score = 98.6 bits (244), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 78/250 (31%), Positives = 122/250 (48%), Gaps = 31/250 (12%) Query: 321 DPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADT 380 DPEEL F K D + G G+FG V +G+ K+ VAIK++ + + Sbjct: 16 DPEEL-----FTKLDRI-------GKGSFGEVYKGIDNHTKEV--VAIKIIDLEEAEDEI 61 Query: 381 EEMMREAQIMHQLDNPYIVRLIG-VCQAEALMLVMEMAGGGPLHKFLV-GKREEIPVSNV 438 E++ +E ++ Q D+PYI R G ++ L ++ME GGG L G EE + + Sbjct: 62 EDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEE---TYI 118 Query: 439 AELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSA 498 A +L ++ G+ YL + +HRD+ A NVLL + K++DFG++ L D+ + Sbjct: 119 ATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQL--TDTQIKRNTF 176 Query: 499 GKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM 558 P W APE I + ++D+WS G+T E L+ G+ P + V+ I Sbjct: 177 VGTPF-WMAPEVIKQSAYDFKADIWSLGITAIE-LAKGEPPNSDLHPMRVLFLI------ 228 Query: 559 ECPPECPPEL 568 P PP L Sbjct: 229 --PKNSPPTL 236 >3COM-A nrPDB Length = 314 Score = 98.2 bits (243), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 59/199 (29%), Positives = 107/199 (53%), Gaps = 10/199 (5%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 +LG G++GSV + +++ + I +KQ ++D +E+++E IM Q D+P++V+ Sbjct: 36 KLGEGSYGSVYKAIHKETGQ-----IVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYY 90 Query: 403 G-VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 G + L +VME G G + + + + + +A +L G++YL +HRD Sbjct: 91 GSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRD 150 Query: 462 LAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSD 521 + A N+LL +AK++DFG++ L D+ + P W APE I ++ +D Sbjct: 151 IKAGNILLNTEGHAKLADFGVAGQL--TDTMAKRNTVIGTPF-WMAPEVIQEIGYNCVAD 207 Query: 522 VWSYGVTMWEALSYGQKPY 540 +WS G+T E ++ G+ PY Sbjct: 208 IWSLGITAIE-MAEGKPPY 225 >4QMW-A nrPDB Length = 310 Score = 97.8 bits (242), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 75/251 (29%), Positives = 126/251 (50%), Gaps = 31/251 (12%) Query: 320 SDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKAD 379 +DPEEL F K + ++G G+FG V +G+ +K VAIK++ + + Sbjct: 25 ADPEEL-----FTKLE-------KIGKGSFGEVFKGIDNRTQKV--VAIKIIDLEEAEDE 70 Query: 380 TEEMMREAQIMHQLDNPYIVRLIG-VCQAEALMLVMEMAGGGPLHKFLV-GKREEIPVSN 437 E++ +E ++ Q D+PY+ + G + L ++ME GGG L G +E + Sbjct: 71 IEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDE---TQ 127 Query: 438 VAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARS 497 +A +L ++ G+ YL + +HRD+ A NVLL K++DFG++ L D+ + Sbjct: 128 IATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQL--TDTQIKRNT 185 Query: 498 AGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKR 557 P W APE I + S++D+WS G+T E L+ G+ P+ ++ +V+ I Sbjct: 186 FVGTPF-WMAPEVIKQSAYDSKADIWSLGITAIE-LARGEPPHSELHPMKVLFLI----- 238 Query: 558 MECPPECPPEL 568 P PP L Sbjct: 239 ---PKNNPPTL 246 >5WNL-A nrPDB Length = 342 Score = 97.1 bits (240), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 76/261 (29%), Positives = 121/261 (46%), Gaps = 22/261 (8%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEE---MMREAQIMHQLDNPYIV 399 ++G G FG V Y++R + + + D E ++ EA+ M YI+ Sbjct: 27 KVGSGGFGQV----YKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYIL 82 Query: 400 RLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE--EKNF 457 + G+CQ E + LVME G L K L E +P ++H+ ++GM +L Sbjct: 83 PVYGICQ-EPVGLVMEYMETGSLEKLLAS--EPLPWDLRFRIVHETAVGMNFLHCMSPPL 139 Query: 458 VHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI--NFRK 515 +H +L N+LL ++ KISDFGL+K G S+ + + + PE I R Sbjct: 140 LHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKSRL 199 Query: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMKGP-EVMAFIEQGKRMECPPECPP------EL 568 F ++ DV+S+ + +W L+ +KP+ K +M + +G R E PP C P L Sbjct: 200 FDTKHDVYSFAIVIWGVLTQ-KKPFADEKNILHIMMKVVKGHRPELPPICRPRPRACASL 258 Query: 569 YALMSDCWIYKWEDRPDFLTV 589 LM CW + RP F + Sbjct: 259 IGLMQRCWHADPQVRPTFQEI 279 >5AR8-A nrPDB Length = 326 Score = 96.7 bits (239), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 77/265 (29%), Positives = 129/265 (48%), Gaps = 30/265 (11%) Query: 345 GCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTE--EMMREAQIMHQLDNPYIVRLI 402 G S R +R + VA+K L T D+E +++REA+I+H+ YI+ ++ Sbjct: 44 ASGTVSSARHADWR-----VQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPIL 98 Query: 403 GVC-QAEALMLVMEMAGGGPLHKFLVGKRE--EIPVSNVAELLHQVSMGMKYLEEKN--F 457 G+C + E L +V E G L++ L K E ++ +LH++++G+ YL Sbjct: 99 GICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPL 158 Query: 458 VHRDLAARNVLLVNRHYAKISDFGLSK--ALGADDSYYTARSAGKWPLKWYAPECINFR- 514 +H DL +N+LL N + KI+DFGLSK + S + + + + PE N+ Sbjct: 159 LHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPE--NYEP 216 Query: 515 ----KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP-EVMAFIEQGKRMECPPECPP--- 566 + S + D++SY V WE LS Q P++ + P ++M + QG R E P Sbjct: 217 GQKSRASIKHDIYSYAVITWEVLSRKQ-PFEDVTNPLQIMYSVSQGHRPVINEESLPYDI 275 Query: 567 ----ELYALMSDCWIYKWEDRPDFL 587 + +L+ W ++RP FL Sbjct: 276 PHRARMISLIESGWAQNPDERPSFL 300 >4LG4-A nrPDB Length = 299 Score = 96.3 bits (238), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 58/199 (29%), Positives = 107/199 (53%), Gaps = 10/199 (5%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 +LG G++GSV + +++ + + +KQ ++D +E+++E IM Q D+PY+V+ Sbjct: 18 KLGEGSYGSVFKAIHKESGQVV-----AIKQVPVESDLQEIIKEISIMQQCDSPYVVKYY 72 Query: 403 G-VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 G + L +VME G G + + + + + +A +L G++YL +HR+ Sbjct: 73 GSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRN 132 Query: 462 LAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSD 521 + A N+LL +AK++DFG++ L D+ + P W APE I ++ +D Sbjct: 133 IKAGNILLNTEGHAKLADFGVAGQL--TDTMAKRNTVIGTPF-WMAPEVIQEIGYNCVAD 189 Query: 522 VWSYGVTMWEALSYGQKPY 540 +WS G+T E ++ G+ PY Sbjct: 190 IWSLGITSIE-MAEGKPPY 207 >5HI2-A nrPDB Length = 283 Score = 96.3 bits (238), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 70/263 (26%), Positives = 122/263 (46%), Gaps = 25/263 (9%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 D + +G G+FG+V +G K DVA+K+L +A E ++ + Sbjct: 19 DGQITVGQRIGSGSFGTVYKG-----KWHGDVAVKMLTPQQLQA----FKNEVGVLRKTR 69 Query: 395 NPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 454 + I+ +G L +V + G L+ L + + + ++ Q + GM YL Sbjct: 70 HVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHA 129 Query: 455 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGA-DDSYYTARSAGKWPLKWYAPECINF 513 K+ +HRDL + N+ L + KI DFGL+ S+ + +G + W APE I Sbjct: 130 KSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSG--SILWMAPEVIRM 187 Query: 514 RK---FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE------- 563 + +S +SDV+++G+ ++E ++ GQ PY + + IE R P+ Sbjct: 188 QDSNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRD--QIIEMVGRGSLSPDLSKVRSN 244 Query: 564 CPPELYALMSDCWIYKWEDRPDF 586 CP + LM++C K ++RP F Sbjct: 245 CPKRMKRLMAECLKKKRDERPSF 267 >4NEU-A nrPDB Length = 333 Score = 96.3 bits (238), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 88/291 (30%), Positives = 142/291 (48%), Gaps = 26/291 (8%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKAD-TEEMMREAQIMHQLDNPYIVRL 401 EL G FG V +R + I +K + +G + E ++ EA++M++L + +V+L Sbjct: 31 ELDSGGFGKVSLCFHRTQGLMI---MKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKL 87 Query: 402 IGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 +GV E LVME G L L + P+S ++ ++ GM YL K +H+ Sbjct: 88 LGVIIEEGKYSLVMEYMEKGNLMHVLKAEMS-TPLSVKGRIILEIIEGMCYLHGKGVIHK 146 Query: 461 DLAARNVLLVNRHYAKISDFGL------SKALGADDSYY-----TARSAGKWPLKWYAPE 509 DL N+L+ N + KI+D GL SK + + TA+ G L + APE Sbjct: 147 DLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNG-GTLYYMAPE 205 Query: 510 CIN--FRKFSSRSDVWSYGVTMWEALSYGQKPYKK-MKGPEVMAFIEQGKR---MECPPE 563 +N K + +SDV+S+ V +W A+ ++PY+ + +++ I+ G R + Sbjct: 206 HLNDVNAKPTEKSDVYSFAVVLW-AIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEY 264 Query: 564 CPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYS-LASKVEGPPGSTQK 613 CP E+ +LM CW E RP F +E++ R Y S L VE S +K Sbjct: 265 CPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKK 315 >6AO5-A nrPDB Length = 362 Score = 95.9 bits (237), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 58/199 (29%), Positives = 107/199 (53%), Gaps = 10/199 (5%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 +LG G++GSV + +++ + + +KQ ++D +E+++E IM Q D+PY+V+ Sbjct: 17 KLGEGSYGSVFKAIHKESGQVV-----AIKQVPVESDLQEIIKEISIMQQCDSPYVVKYY 71 Query: 403 G-VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 G + L +VME G G + + + + + +A +L G++YL +HR+ Sbjct: 72 GSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRN 131 Query: 462 LAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSD 521 + A N+LL +AK++DFG++ L D+ + P W APE I ++ +D Sbjct: 132 IKAGNILLNTEGHAKLADFGVAGQLT--DTMAKRNTVIGTPF-WMAPEVIQEIGYNCVAD 188 Query: 522 VWSYGVTMWEALSYGQKPY 540 +WS G+T E ++ G+ PY Sbjct: 189 IWSLGITSIE-MAEGKPPY 206 >3DFA-A nrPDB Length = 286 Score = 93.2 bits (230), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 72/243 (29%), Positives = 125/243 (51%), Gaps = 19/243 (7%) Query: 320 SDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEK-A 378 S E L + F +R N++ LG G+FG V + + R Q + A+KV+ + + K Sbjct: 9 SGRENLYFQGTFAERYNIVCM---LGKGSFGEVLKC--KDRITQQEYAVKVINKASAKNK 63 Query: 379 DTEEMMREAQIMHQLDNPYIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVGKREEIPVSN 437 DT ++RE +++ +LD+P I++L + + + + +V E+ GG L ++ KR+ + Sbjct: 64 DTSTILREVELLKKLDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEII-KRKRFSEHD 122 Query: 438 VAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHY---AKISDFGLSKALGADDSYYT 494 A ++ QV G+ Y+ + N VHRDL N+LL ++ KI DFGLS + Sbjct: 123 AARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQN----- 177 Query: 495 ARSAGKWPLKWY-APECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIE 553 + + +Y APE + + + DVWS GV ++ LS G P+ +++ +E Sbjct: 178 TKMKDRIGTAYYIAPEVLR-GTYDEKCDVWSAGVILYILLS-GTPPFYGKNEYDILKRVE 235 Query: 554 QGK 556 GK Sbjct: 236 TGK 238 >4FZF-B nrPDB Length = 283 Score = 92.4 bits (228), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 76/251 (30%), Positives = 123/251 (49%), Gaps = 31/251 (12%) Query: 320 SDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKAD 379 +DPEEL K L+R +G G+FG V +G+ R +Q+ VAIK++ + + Sbjct: 4 ADPEELFTK---LER---------IGKGSFGEVFKGIDN-RTQQV-VAIKIIDLEEAEDE 49 Query: 380 TEEMMREAQIMHQLDNPYIVRLIG-VCQAEALMLVMEMAGGGPLHKFL-VGKREEIPVSN 437 E++ +E ++ Q D+ Y+ + G + L ++ME GGG L G +E Sbjct: 50 IEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEF---Q 106 Query: 438 VAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARS 497 +A +L ++ G+ YL + +HRD+ A NVLL + K++ FG++ L D+ + Sbjct: 107 IATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQL--TDTQIKRNT 164 Query: 498 AGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKR 557 P W APE I + S++D+WS G+T E L+ G+ P M V+ I Sbjct: 165 FVGTPF-WMAPEVIQQSAYDSKADIWSLGITAIE-LAKGEPPNSDMHPMRVLFLI----- 217 Query: 558 MECPPECPPEL 568 P PP L Sbjct: 218 ---PKNNPPTL 225 >3NCG-A nrPDB Length = 486 Score = 91.7 bits (226), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 65/219 (29%), Positives = 116/219 (52%), Gaps = 16/219 (7%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEK-ADTEEMMREAQIMHQLDNPYIVRLI 402 LG G+FG V + R+ +++ A+KV+ + + K DT ++RE +++ +LD+P I++L Sbjct: 30 LGKGSFGEVLKCKDRITQQE--YAVKVINKASAKNKDTSTILREVELLKKLDHPNIMKLF 87 Query: 403 GVCQ-AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 + + + + +V E+ GG L ++ KR+ + A ++ QV G+ Y+ + N VHRD Sbjct: 88 EILEDSSSFYIVGELYTGGELFDEII-KRKRFSEHDAARIIKQVFSGITYMHKHNIVHRD 146 Query: 462 LAARNVLLVNRHY---AKISDFGLSKALGADDSYYTARSAGKWPLKWY-APECINFRKFS 517 L N+LL ++ KI DFGLS + + + +Y APE + + Sbjct: 147 LKPENILLESKEKDCDIKIIDFGLSTCFQQN-----TKMKDRIGTAYYIAPEVLR-GTYD 200 Query: 518 SRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK 556 + DVWS GV ++ LS G P+ +++ +E GK Sbjct: 201 EKCDVWSAGVILYILLS-GTPPFYGKNEYDILKRVETGK 238 >5HIE-A nrPDB Length = 302 Score = 90.1 bits (222), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 69/262 (26%), Positives = 122/262 (46%), Gaps = 23/262 (8%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 D + +G G+FG+V +G K DVA+K+L +A E ++ + Sbjct: 35 DGQITVGQRIGSGSFGTVYKG-----KWHGDVAVKMLTPQQLQA----FKNEVGVLRKTR 85 Query: 395 NPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 454 + I+ +G L +V + G L+ L + + + ++ Q + GM YL Sbjct: 86 HVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHA 145 Query: 455 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGA-DDSYYTARSAGKWPLKWYAPECINF 513 K+ +HRDL + N+ L KI DFGL+ S+ + +G + W APE I Sbjct: 146 KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSG--SILWMAPEVIRM 203 Query: 514 RK---FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECP------PEC 564 + +S +SDV+++G+ ++E ++ GQ PY + + + F+ G+ P C Sbjct: 204 QDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMV-GRGYLSPDLSKVRSNC 261 Query: 565 PPELYALMSDCWIYKWEDRPDF 586 P + LM++C K ++RP F Sbjct: 262 PKAMKRLMAECLKKKRDERPLF 283 >4AN9-A nrPDB Length = 301 Score = 89.4 bits (220), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 74/258 (28%), Positives = 129/258 (50%), Gaps = 34/258 (13%) Query: 343 ELGCGNFGSVRQGVYR-----MRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPY 397 ELG GN G V + ++ M +K I + IK A +++RE Q++H+ ++PY Sbjct: 16 ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIK-------PAIRNQIIRELQVLHECNSPY 68 Query: 398 IVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 IV G ++ + + ME GG L + L K IP + ++ V G+ YL EK+ Sbjct: 69 IVGFYGAFYSDGEISICMEHMDGGSLDQVL-KKAGRIPEQILGKVSIAVIKGLTYLREKH 127 Query: 457 -FVHRDLAARNVLLVNRHYAKISDFGLSKALGAD--DSYYTARSAGKWPLKWYAPECINF 513 +HRD+ N+L+ +R K+ DFG+S L + + + RS + +PE + Sbjct: 128 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTRS-------YMSPERLQG 180 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYAL-- 571 +S +SD+WS G+++ E ++ G+ P M E++ +I E PP+ P +++L Sbjct: 181 THYSVQSDIWSMGLSLVE-MAVGRYPRPPMAIFELLDYIVN----EPPPKLPSAVFSLEF 235 Query: 572 ---MSDCWIYKWEDRPDF 586 ++ C I +R D Sbjct: 236 QDFVNKCLIKNPAERADL 253 >5KZ7-A nrPDB Length = 346 Score = 89.0 bits (219), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 69/217 (31%), Positives = 106/217 (48%), Gaps = 13/217 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G GNF V+ + + K++ V I + K + +++ RE +IM L++P IV+L Sbjct: 41 IGKGNFAKVKLARHILTGKEVAVKI-IDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFE 99 Query: 404 VCQAE-ALMLVMEMAGGGPLHKFLV--GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 V + E L LVME A GG + +LV G+ +E Q+ ++Y +K VHR Sbjct: 100 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKE---KEARAKFRQIVSAVQYCHQKFIVHR 156 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS-R 519 DL A N+LL KI+DFG S + T G P + APE +K+ Sbjct: 157 DLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTF--CGSPP--YAAPELFQGKKYDGPE 212 Query: 520 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK 556 DVWS GV ++ +S G P+ E+ + +GK Sbjct: 213 VDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRGK 248 >3DAK-A nrPDB Length = 290 Score = 88.6 bits (218), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 70/222 (31%), Positives = 112/222 (50%), Gaps = 15/222 (6%) Query: 332 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMH 391 + RD+ + ++ +G G +V Q Y KK+ VAIK + + +E+++E Q M Sbjct: 7 INRDDYELQEV-IGSGA-TAVVQAAYCAPKKE-KVAIKRINLEKCQTSMDELLKEIQAMS 63 Query: 392 QLDNPYIVRL-IGVCQAEALMLVMEMAGGGP---LHKFLVGKREE----IPVSNVAELLH 443 Q +P IV + L LVM++ GG + K +V K E + S +A +L Sbjct: 64 QCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILR 123 Query: 444 QVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSK--ALGADDSYYTARSAGKW 501 +V G++YL + +HRD+ A N+LL +I+DFG+S A G D + R Sbjct: 124 EVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVG 183 Query: 502 PLKWYAPECI-NFRKFSSRSDVWSYGVTMWEALSYGQKPYKK 542 W APE + R + ++D+WS+G+T E L+ G PY K Sbjct: 184 TPCWMAPEVMEQVRGYDFKADIWSFGITAIE-LATGAAPYHK 224 >4L00-A nrPDB Length = 304 Score = 88.6 bits (218), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 69/240 (28%), Positives = 111/240 (46%), Gaps = 23/240 (9%) Query: 361 KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEAL-MLVMEMAGG 419 +K+I V +KVL + + + A +M Q+ + +IV L GVC + ++V E G Sbjct: 58 EKKIKVILKVL-DPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEG 116 Query: 420 GPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRH------ 473 GPL F+ K + + ++ Q++ + YLE+K+ VH ++ +N+LL Sbjct: 117 GPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECG 176 Query: 474 -YAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRKFSSRSDVWSYGVTMWE 531 + K+SD G+ + +R + W APEC+ + + S +D WS+G T+WE Sbjct: 177 PFIKLSDPGIPITV-------LSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWE 229 Query: 532 ALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPP--ELYALMSDCWIYKWEDRPDFLTV 589 G+ P K E F E C P P EL LM+ C Y RP F + Sbjct: 230 ICYNGEIPLKDKTLIEKERFYES----RCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI 285 >2HAK-A nrPDB Length = 328 Score = 88.6 bits (218), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 68/217 (31%), Positives = 105/217 (48%), Gaps = 13/217 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G GNF V+ + + +++ V I + K +++ RE +IM L++P IV+L Sbjct: 23 IGKGNFAKVKLARHVLTGREVAVKI-IDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 81 Query: 404 VCQAE-ALMLVMEMAGGGPLHKFLV--GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 V + E L LVME A GG + +LV G+ +E Q+ ++Y +K VHR Sbjct: 82 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKE---KEARAKFRQIVSAVQYCHQKYIVHR 138 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS-R 519 DL A N+LL KI+DFG S + T G P + APE +K+ Sbjct: 139 DLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTF--CGSPP--YAAPELFQGKKYDGPE 194 Query: 520 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK 556 DVWS GV ++ +S G P+ E+ + +GK Sbjct: 195 VDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRGK 230 >5D9K-A nrPDB Length = 330 Score = 88.2 bits (217), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 77/265 (29%), Positives = 131/265 (49%), Gaps = 19/265 (7%) Query: 344 LGCGNFGSV--RQGVYRMRKKQIDVAIKVLKQGTEKA-DTEEMMREAQIMHQLDNPYIVR 400 LG G+FG V + + +Q+ A+KVLK+ T K D E I+ ++++P+IV+ Sbjct: 38 LGQGSFGKVFLVKKISGSDARQL-YAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVK 96 Query: 401 LIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 L Q E L L+++ GG L L K +V L ++++ + +L ++ Sbjct: 97 LHYAFQTEGKLYLILDFLRGGDLFTRL-SKEVMFTEEDVKFYLAELALALDHLHSLGIIY 155 Query: 460 RDLAARNVLLVNRHYAKISDFGLSK-ALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 RDL N+LL + K++DFGLSK ++ + Y+ +++ APE +N R + Sbjct: 156 RDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGT----VEYMAPEVVNRRGHTQ 211 Query: 519 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIY 578 +D WS+GV M+E L+ G P++ E M I + K + P PE +L+ + Sbjct: 212 SADWWSFGVLMFEMLT-GTLPFQGKDRKETMTMILKAK-LGMPQFLSPEAQSLLRMLFKR 269 Query: 579 KWEDR----PDFLTVEQRMRACYYS 599 +R PD VE+ R ++S Sbjct: 270 NPANRLGAGPD--GVEEIKRHSFFS 292 >2Z7Q-A nrPDB Length = 321 Score = 88.2 bits (217), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 69/218 (31%), Positives = 111/218 (50%), Gaps = 12/218 (5%) Query: 344 LGCGNFGSV--RQGVYRMRKKQIDVAIKVLKQGTEKA-DTEEMMREAQIMHQLDNPYIVR 400 LG G+FG V + V R + A+KVLK+ T K D E I+ +++P++V+ Sbjct: 36 LGQGSFGKVFLVRKVTRPDSGHL-YAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVK 94 Query: 401 LIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 L Q E L L+++ GG L L K +V L ++++G+ +L ++ Sbjct: 95 LHYAFQTEGKLYLILDFLRGGDLFTRL-SKEVMFTEEDVKFYLAELALGLDHLHSLGIIY 153 Query: 460 RDLAARNVLLVNRHYAKISDFGLSK-ALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 RDL N+LL + K++DFGLSK A+ + Y+ +++ APE +N + S Sbjct: 154 RDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGT----VEYMAPEVVNRQGHSH 209 Query: 519 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK 556 +D WSYGV M+E L+ G P++ E M I + K Sbjct: 210 SADWWSYGVLMFEMLT-GSLPFQGKDRKETMTLILKAK 246 >5ES1-A nrPDB Length = 328 Score = 87.8 bits (216), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 71/221 (32%), Positives = 111/221 (50%), Gaps = 21/221 (9%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 +G GNF V+ + + ++ VAIK++ K + +++ RE +IM L++P IV+L Sbjct: 23 IGKGNFAKVKLARHILTGRE--VAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLF 80 Query: 403 GVCQAE-ALMLVMEMAGGGPLHKFLV--GKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 V + E L LVME A G + +LV G+ +E Q+ + Y +KN VH Sbjct: 81 EVIETEKTLYLVMEYASAGEVFDYLVSHGRMKE---KEARAKFRQIVSAVHYCHQKNIVH 137 Query: 460 RDLAARNVLLVNRHYAKISDFGLSK--ALGAD-DSYYTARSAGKWPLKWYAPECINFRKF 516 RDL A N+LL KI+DFG S LG+ D++ G P + APE +K+ Sbjct: 138 RDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTF-----CGSPP--YAAPELFQGKKY 190 Query: 517 SS-RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK 556 D+WS GV ++ +S G P+ E+ + +GK Sbjct: 191 DGPEVDIWSLGVILYTLVS-GSLPFDGHNLKELRERVLRGK 230 >5C01-A nrPDB Length = 342 Score = 87.8 bits (216), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 68/242 (28%), Positives = 110/242 (45%), Gaps = 20/242 (8%) Query: 358 RMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEM 416 R R +++ V +KVL A +M Q+ + ++ + GVC + ++V E Sbjct: 102 RDRGQELRVVLKVLDPSHHDIALA-FYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEY 160 Query: 417 AGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLV------ 470 GPL +L +R +P++ + Q++ + YLE KN VH ++ RN+LL Sbjct: 161 VEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAE 220 Query: 471 -NRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI--NFRKFSSRSDVWSYGV 527 + K+SD G+ LGA +R + W APEC+ S+ D W +G Sbjct: 221 GTSPFIKLSDPGV--GLGA-----LSREERVERIPWLAPECLPGGANSLSTAMDKWGFGA 273 Query: 528 TMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFL 587 T+ E G+ P + E F ++ R+ P C P+L L S C Y+ RP F Sbjct: 274 TLLEICFDGEAPLQSRSPSEKEHFYQRQHRLP-EPSC-PQLATLTSQCLTYEPTQRPSFR 331 Query: 588 TV 589 T+ Sbjct: 332 TI 333 >2QNJ-A nrPDB Length = 328 Score = 87.8 bits (216), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 70/221 (31%), Positives = 109/221 (49%), Gaps = 21/221 (9%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 +G GNF V+ + + ++ VAIK++ K +++ RE +IM L++P IV+L Sbjct: 20 IGKGNFAKVKLARHILTGRE--VAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLF 77 Query: 403 GVCQAE-ALMLVMEMAGGGPLHKFLV--GKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 V + E L L+ME A GG + +LV G+ +E Q+ ++Y +K VH Sbjct: 78 EVIETEKTLYLIMEYASGGEVFDYLVAHGRMKE---KEARSKFRQIVSAVQYCHQKRIVH 134 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKAL---GADDSYYTARSAGKWPLKWYAPECINFRKF 516 RDL A N+LL KI+DFG S G D++ G P + APE +K+ Sbjct: 135 RDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTF-----CGSPP--YAAPELFQGKKY 187 Query: 517 SS-RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK 556 DVWS GV ++ +S G P+ E+ + +GK Sbjct: 188 DGPEVDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRGK 227 >6C9D-A nrPDB Length = 459 Score = 87.4 bits (215), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 67/217 (30%), Positives = 104/217 (47%), Gaps = 13/217 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G GNF V+ + + +++ V I + K +++ RE +IM L++P IV+L Sbjct: 29 IGKGNFAKVKLARHVLTGREVAVKI-IDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFE 87 Query: 404 VCQAE-ALMLVMEMAGGGPLHKFLV--GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 V + E L LVME A GG + +LV G+ +E Q+ ++Y +K VHR Sbjct: 88 VIETEKTLYLVMEYASGGEVFDYLVAHGRMKE---KEARAKFRQIVSAVQYCHQKYIVHR 144 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS-R 519 DL A N+LL KI+DFG S + G P + APE +K+ Sbjct: 145 DLKAENLLLDGDMNIKIADFGFSNEFTVGNKL--DEFCGSPP--YAAPELFQGKKYDGPE 200 Query: 520 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK 556 DVWS GV ++ +S G P+ E+ + +GK Sbjct: 201 VDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRGK 236 >4WOV-A nrPDB Length = 317 Score = 87.0 bits (214), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 68/242 (28%), Positives = 110/242 (45%), Gaps = 20/242 (8%) Query: 358 RMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEM 416 R R +++ V +KVL A +M Q+ + ++ + GVC + ++V E Sbjct: 79 RDRGQELRVVLKVLDPSHHDIALA-FYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEY 137 Query: 417 AGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLV------ 470 GPL +L +R +P++ + Q++ + YLE KN VH ++ RN+LL Sbjct: 138 VEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAE 197 Query: 471 -NRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI--NFRKFSSRSDVWSYGV 527 + K+SD G+ LGA +R + W APEC+ S+ D W +G Sbjct: 198 GTSPFIKLSDPGV--GLGA-----LSREERVERIPWLAPECLPGGANSLSTAMDKWGFGA 250 Query: 528 TMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFL 587 T+ E G+ P + E F ++ R+ P C P+L L S C Y+ RP F Sbjct: 251 TLLEICFDGEAPLQSRSPSEKEHFYQRQHRLP-EPSC-PQLATLTSQCLTYEPTQRPSFR 308 Query: 588 TV 589 T+ Sbjct: 309 TI 310 >3MA6-A nrPDB Length = 298 Score = 87.0 bits (214), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 65/218 (29%), Positives = 111/218 (50%), Gaps = 13/218 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LG G+FG V ++ ++ V + +Q +K D E ++RE Q++ QLD+P I++L Sbjct: 40 LGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYE 99 Query: 404 VCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 + + LV E+ GG L ++ R+ + A ++ QV G+ Y+ + VHRDL Sbjct: 100 FFEDKGYFYLVGEVYTGGELFDEIIS-RKRFSEVDAARIIRQVLSGITYMHKNKIVHRDL 158 Query: 463 AARNVLLVNRH---YAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APECINFRKFSS 518 N+LL ++ +I DFGLS A + + K +Y APE ++ + Sbjct: 159 KPENLLLESKSKDANIRIIDFGLSTHFEA-----SKKMKDKIGTAYYIAPEVLH-GTYDE 212 Query: 519 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK 556 + DVWS GV ++ LS G P+ +++ +E+GK Sbjct: 213 KCDVWSTGVILYILLS-GCPPFNGANEYDILKKVEKGK 249 >4MVF-A nrPDB Length = 506 Score = 86.7 bits (213), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 69/222 (31%), Positives = 113/222 (50%), Gaps = 14/222 (6%) Query: 339 IADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYI 398 I D +LG G +G V +G+ ++ + AIK K+ K + +E +IM +LD+P I Sbjct: 60 IIDEKLGQGTYGCVYKGIDKVTNQL--YAIKEEKKDRLK-NINRFFQEIEIMKKLDHPNI 116 Query: 399 VRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNF 457 V+L + + + L+ME+ G L ++ + N A ++ Q+ + YL N Sbjct: 117 VKLYETYENDNYIYLIMELCSGRELFDSII-ENGSFTEKNAATIMKQIFSAIFYLHSLNI 175 Query: 458 VHRDLAARNVLLVNRH---YAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR 514 VHRDL N L + + KI DFGLSK LG + +T AG P + AP+ ++ Sbjct: 176 VHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGE--FTTTKAGT-PY-YVAPQVLD-G 230 Query: 515 KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK 556 K+ + D+WS GV M+ L G P+ EV+ +++G+ Sbjct: 231 KYDKKCDIWSSGVIMYTLLC-GYPPFYGDTDNEVLKKVKKGE 271 >6QAU-A nrPDB Length = 280 Score = 86.7 bits (213), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 72/255 (28%), Positives = 124/255 (48%), Gaps = 19/255 (7%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G G F V +G +R +K +VAIK + + + +E +I+ +L + IV L Sbjct: 19 VGHGAFAVVFRGRHR-QKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYD 77 Query: 404 VCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 V + ++ LVME GG L +L K + + LHQ++ M+ L K +HRDL Sbjct: 78 VQELPNSVFLVMEYCNGGDLADYLQAK-GTLSEDTIRVFLHQIAAAMRILHSKGIIHRDL 136 Query: 463 AARNVLL--VNRHYA-------KISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF 513 +N+LL NR + KI+DFG ++ L ++ A P+ + APE I Sbjct: 137 KPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSN---MMAADLCGSPM-YMAPEVIMS 192 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM--ECPPECPPELYAL 571 + + +++D+WS G +++ L G+ P++ ++ F E+ + + P E P L L Sbjct: 193 QHYDAKADLWSIGTVIYQCL-VGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANL 251 Query: 572 MSDCWIYKWEDRPDF 586 + +DR DF Sbjct: 252 LLGLLQRNQKDRMDF 266 >5JN2-A nrPDB Length = 525 Score = 86.3 bits (212), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 65/218 (29%), Positives = 111/218 (50%), Gaps = 13/218 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LG G+FG V ++ ++ V + +Q +K D E ++RE Q++ QLD+P I++L Sbjct: 75 LGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYE 134 Query: 404 VCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 + + LV E+ GG L ++ R+ + A ++ QV G+ Y+ + VHRDL Sbjct: 135 FFEDKGYFYLVGEVYTGGELFDEIIS-RKRFSEVDAARIIRQVLSGITYMHKNKIVHRDL 193 Query: 463 AARNVLLVNRH---YAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APECINFRKFSS 518 N+LL ++ +I DFGLS A + + K +Y APE ++ + Sbjct: 194 KPENLLLESKSKDANIRIIDFGLSTHFEA-----SKKMKDKIGTAYYIAPEVLH-GTYDE 247 Query: 519 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK 556 + DVWS GV ++ LS G P+ +++ +E+GK Sbjct: 248 KCDVWSTGVILYILLS-GCPPFNGANEYDILKKVEKGK 284 >5O0Y-A nrPDB Length = 579 Score = 86.3 bits (212), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 72/225 (32%), Positives = 109/225 (48%), Gaps = 30/225 (13%) Query: 385 REAQIMHQLDNPYIVRLIGV--CQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELL 442 RE +I +LD+P IV+L ++ V+E G L F + + + + ++ Sbjct: 337 REYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDL-DFYLKQHKLMSEKEARSII 395 Query: 443 HQVSMGMKYLEEKN--FVHRDLAARNVLLVNRHYA---KISDFGLSKALGADDSY----- 492 Q+ +KYL E +H DL N+LLVN KI+DFGLSK + DDSY Sbjct: 396 MQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMD-DDSYNSVDG 454 Query: 493 --YTARSAGKWPLKWYA-PECINFR----KFSSRSDVWSYGVTMWEALSYGQKPYKKMKG 545 T++ AG + WY PEC K S++ DVWS GV ++ L YG+KP+ + Sbjct: 455 MELTSQGAGTY---WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCL-YGRKPFGHNQS 510 Query: 546 PEVM---AFIEQGKRMECPPE--CPPELYALMSDCWIYKWEDRPD 585 + + I + ++ PP+ PE A + C Y+ EDR D Sbjct: 511 QQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRID 555 >4REW-A nrPDB Length = 540 Score = 85.9 bits (211), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 68/216 (31%), Positives = 102/216 (47%), Gaps = 12/216 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTE-EMMREAQIMHQLDNPYIVRL 401 LG G FG V+ G + + + VA+K+L +Q D ++ RE Q + +P+I++L Sbjct: 14 LGVGTFGKVKVGKHELTGHK--VAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKL 71 Query: 402 IGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 V + + +VME GG L ++ K + L Q+ G+ Y VHR Sbjct: 72 YQVISTPSDIFMVMEYVSGGELFDYIC-KNGRLDEKESRRLFQQILSGVDYCHRHMVVHR 130 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS-R 519 DL NVLL AKI+DFGLS + D + S G + APE I+ R ++ Sbjct: 131 DLKPENVLLDAHMNAKIADFGLSNMMS--DGEFLRTSCGSP--NYAAPEVISGRLYAGPE 186 Query: 520 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG 555 D+WS GV ++ AL G P+ P + I G Sbjct: 187 VDIWSSGVILY-ALLCGTLPFDDDHVPTLFKKICDG 221 >5EZV-A nrPDB Length = 560 Score = 85.9 bits (211), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 74/241 (30%), Positives = 113/241 (46%), Gaps = 17/241 (7%) Query: 321 DPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKAD 379 DP E + +K + ++ D LG G FG V+ G +++ + VA+K+L +Q D Sbjct: 14 DPAEKQKHDGRVKIGHYVLGDT-LGVGTFGKVKIGEHQLTGHK--VAVKILNRQKIRSLD 70 Query: 380 TE-EMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLV--GKREEIPV 435 ++ RE Q + +P+I++L V +VME GG L ++ G+ EE+ Sbjct: 71 VVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEM-- 128 Query: 436 SNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTA 495 L Q+ + Y VHRDL NVLL AKI+DFGLS + D + Sbjct: 129 -EARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS--DGEFLR 185 Query: 496 RSAGKWPLKWYAPECINFRKFSS-RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 554 S G + APE I+ R ++ D+WS GV ++ AL G P+ P + I Sbjct: 186 TSCGSP--NYAAPEVISGRLYAGPEVDIWSCGVILY-ALLCGTLPFDDEHVPTLFKKIRG 242 Query: 555 G 555 G Sbjct: 243 G 243 >1S9I-A nrPDB Length = 354 Score = 85.5 bits (210), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 62/201 (30%), Positives = 108/201 (53%), Gaps = 15/201 (7%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ELG GN G V + + R + +A K++ + A +++RE Q++H+ ++PYIV Sbjct: 23 ELGAGNGGVVTK--VQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFY 80 Query: 403 GVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN-FVHR 460 G ++ + + ME GG L + L + + IP + ++ V G+ YL EK+ +HR Sbjct: 81 GAFYSDGEISICMEHMDGGSLDQVL-KEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHR 139 Query: 461 DLAARNVLLVNRHYAKISDFGLSKAL--GADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 D+ N+L+ +R K+ DFG+S L +S+ RS + APE + +S Sbjct: 140 DVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS-------YMAPERLQGTHYSV 192 Query: 519 RSDVWSYGVTMWEALSYGQKP 539 +SD+WS G+++ E L+ G+ P Sbjct: 193 QSDIWSMGLSLVE-LAVGRYP 212 >3IS5-A nrPDB Length = 285 Score = 85.5 bits (210), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 67/241 (27%), Positives = 116/241 (48%), Gaps = 18/241 (7%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 D+L I +LG G FG V + R ++ IK + + + E++ E +++ LD Sbjct: 21 DDLFIFKRKLGSGAFGDVH--LVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLKSLD 78 Query: 395 NPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKR---EEIPVSNVAELLHQVSMGMK 450 +P I+++ V + + +VME GG L + +V + + + VAEL+ Q+ + Sbjct: 79 HPNIIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALA 138 Query: 451 YLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYA 507 Y ++ VH+DL N+L + KI DFGL++ +D+ ++ +AG + A Sbjct: 139 YFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDE--HSTNAAG--TALYMA 194 Query: 508 PECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVM---AFIEQGKRMECPPEC 564 PE R + + D+WS GV M+ L+ G P+ EV + E +EC P Sbjct: 195 PEVFK-RDVTFKCDIWSAGVVMYFLLT-GCLPFTGTSLEEVQQKATYKEPNYAVECRPLT 252 Query: 565 P 565 P Sbjct: 253 P 253 >4CFH-A nrPDB Length = 493 Score = 84.7 bits (208), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 68/216 (31%), Positives = 102/216 (47%), Gaps = 12/216 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTE-EMMREAQIMHQLDNPYIVRL 401 LG G FG V+ G + + + VA+K+L +Q D ++ RE Q + +P+I++L Sbjct: 41 LGVGTFGKVKVGKHELTGHK--VAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKL 98 Query: 402 IGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 V + + +VME GG L + + K + L Q+ G+ Y VHR Sbjct: 99 YQVISTPSDIFMVMEYVSGGELFDY-ICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHR 157 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS-R 519 DL NVLL AKI+DFGLS + D + S G + APE I+ R ++ Sbjct: 158 DLKPENVLLDAHMNAKIADFGLSNMMS--DGEFLRTSCGSP--NYAAPEVISGRLYAGPE 213 Query: 520 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG 555 D+WS GV ++ AL G P+ P + I G Sbjct: 214 VDIWSSGVILY-ALLCGTLPFDDDHVPTLFKKICDG 248 >4CFF-A nrPDB Length = 571 Score = 84.7 bits (208), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 69/218 (31%), Positives = 103/218 (47%), Gaps = 16/218 (7%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTE-EMMREAQIMHQLDNPYIVRL 401 LG G FG V+ G +++ + VA+K+L +Q D ++ RE Q + +P+I++L Sbjct: 41 LGVGTFGKVKIGEHQLTGHK--VAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 98 Query: 402 IGVCQAEA-LMLVMEMAGGGPLHKFLV--GKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 V +VME GG L ++ G+ EE+ L Q+ + Y V Sbjct: 99 YQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEM---EARRLFQQILSAVDYCHRHMVV 155 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 HRDL NVLL AKI+DFGLS + D + S G + APE I+ R ++ Sbjct: 156 HRDLKPENVLLDAHMNAKIADFGLSNMMS--DGEFLRTSCGSP--NYAAPEVISGRLYAG 211 Query: 519 -RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG 555 D+WS GV ++ AL G P+ P + I G Sbjct: 212 PEVDIWSCGVILY-ALLCGTLPFDDEHVPTLFKKIRGG 248 >5DBX-A nrPDB Length = 328 Score = 84.3 bits (207), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 63/210 (30%), Positives = 105/210 (50%), Gaps = 14/210 (6%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL-I 402 +G G V+ + + R+++ VAIK + + +E+++E Q M Q +P +V Sbjct: 19 IGSGATAVVQAALCKPRQER--VAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTYYT 76 Query: 403 GVCQAEALMLVMEMAGGGPLH---KFLVGKREE----IPVSNVAELLHQVSMGMKYLEEK 455 + L LVM++ GG + K++V + E + + +A +L +V G+ YL Sbjct: 77 SFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRN 136 Query: 456 NFVHRDLAARNVLLVNRHYAKISDFGLSK--ALGADDSYYTARSAGKWPLKWYAPECI-N 512 +HRDL A N+LL +I+DFG+S A G D + R W APE + Sbjct: 137 GQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPCWMAPEVMEQ 196 Query: 513 FRKFSSRSDVWSYGVTMWEALSYGQKPYKK 542 R + ++D+WS+G+T E L+ G PY K Sbjct: 197 VRGYDFKADMWSFGITAIE-LATGAAPYHK 225 >4RA4-A nrPDB Length = 355 Score = 84.3 bits (207), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 67/207 (32%), Positives = 104/207 (50%), Gaps = 23/207 (11%) Query: 344 LGCGNFGSV----RQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQIMHQLDNPY 397 LG G+FG V R+G + AIK+LK+ + D E M E +++ LD P Sbjct: 28 LGKGSFGKVMLADRKGTEEL------YAIKILKKDVVIQDDDVECTMVEKRVLALLDKPP 81 Query: 398 IVRLIGVC--QAEALMLVMEMAGGGPL--HKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 + + C + L VME GG L H VGK +E A ++S+G+ +L Sbjct: 82 FLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAA---EISIGLFFLH 138 Query: 454 EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF 513 ++ ++RDL NV+L + + KI+DFG+ K D T R+ P + APE I + Sbjct: 139 KRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDG--VTTRTFCGTP-DYIAPEIIAY 195 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPY 540 + + D W+YGV ++E L+ GQ P+ Sbjct: 196 QPYGKSVDWWAYGVLLYEMLA-GQPPF 221 >3Q5I-A nrPDB Length = 504 Score = 84.3 bits (207), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 70/231 (30%), Positives = 114/231 (49%), Gaps = 27/231 (11%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQ-----GTEKADT-------EEMMREAQIM 390 +LG G +G V + + + + AIKV+K+ G D EE+ E ++ Sbjct: 43 KLGSGAYGEVL--LCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYNEISLL 100 Query: 391 HQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGM 449 LD+P I++L V + + LV E GG L + ++ R + + A ++ Q+ G+ Sbjct: 101 KSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIIN-RHKFDECDAANIMKQILSGI 159 Query: 450 KYLEEKNFVHRDLAARNVLLVNRH---YAKISDFGLSKALGADDSYYTARSAGKWPLKWY 506 YL + N VHRD+ N+LL N++ KI DFGLS D Y R + +Y Sbjct: 160 CYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKD---YKLRD--RLGTAYY 214 Query: 507 -APECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK 556 APE + +K++ + DVWS GV M+ L G P+ +++ +E+GK Sbjct: 215 IAPEVLK-KKYNEKCDVWSCGVIMYILLC-GYPPFGGQNDQDIIKKVEKGK 263 >4RED-A nrPDB Length = 351 Score = 84.3 bits (207), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 68/216 (31%), Positives = 101/216 (46%), Gaps = 12/216 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTE-EMMREAQIMHQLDNPYIVRL 401 LG G FG V+ G + + VA+K+L +Q D ++ RE Q + +P+I++L Sbjct: 22 LGVGTFGKVKVGKHELTGHA--VAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKL 79 Query: 402 IGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 V + + +VME GG L ++ K + L Q+ G+ Y VHR Sbjct: 80 YQVISTPSDIFMVMEYVSGGELFDYIC-KNGRLDEKESRRLFQQILSGVDYCHRHMVVHR 138 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS-R 519 DL NVLL AKI+DFGLS + D + S G + APE I+ R ++ Sbjct: 139 DLKPENVLLDAHMNAKIADFGLSNMMS--DGEFLRTSCGSP--NYAAPEVISGRLYAGPE 194 Query: 520 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG 555 D+WS GV ++ AL G P+ P + I G Sbjct: 195 VDIWSSGVILY-ALLCGTLPFDDDHVPTLFKKICDG 229 >4WNO-A nrPDB Length = 287 Score = 83.6 bits (205), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 69/255 (27%), Positives = 119/255 (46%), Gaps = 19/255 (7%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G G F V +G +R ++VA+K + + + +E +I+ +L + IV L Sbjct: 26 IGHGAFAVVFKGRHRA-AHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYD 84 Query: 404 VCQ-AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 + A ++ LVME GG L +L R + + L Q++ M+ L K +HRDL Sbjct: 85 FQEMANSVYLVMEYCNGGDLADYLHAMRT-LSEDTIRLFLQQIAGAMRLLHSKGIIHRDL 143 Query: 463 AARNVLLV---------NRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF 513 +N+LL N KI+DFG ++ L S A + P+ + APE I Sbjct: 144 KPQNILLSNPAGRRANPNSIRVKIADFGFARYL---QSNMMAATLCGSPM-YMAPEVIMS 199 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM--ECPPECPPELYAL 571 + + ++D+WS G +++ L+ G+ P++ ++ F E+ K + P E L L Sbjct: 200 QHYDGKADLWSIGTIVYQCLT-GKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQL 258 Query: 572 MSDCWIYKWEDRPDF 586 + +DR DF Sbjct: 259 LLALLQRNHKDRMDF 273 >2YAB-A nrPDB Length = 361 Score = 82.8 bits (203), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 63/220 (28%), Positives = 108/220 (49%), Gaps = 18/220 (8%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADT-----EEMMREAQIMHQLDNPY 397 ELG G F V++ R + ++ A K +K+ +A EE+ RE I+ Q+ +P Sbjct: 19 ELGSGQFAIVKKC--REKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVLHPN 76 Query: 398 IVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 I+ L V + ++L++E+ GG L FL ++E + + Q+ G+ YL K Sbjct: 77 IITLHDVYENRTDVVLILELVSGGELFDFL-AQKESLSEEEATSFIKQILDGVNYLHTKK 135 Query: 457 FVHRDLAARNVLLVNRH----YAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN 512 H DL N++L++++ + K+ DFGL+ + +D G P ++ APE +N Sbjct: 136 IAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEI--EDGVEFKNIFGT-P-EFVAPEIVN 191 Query: 513 FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI 552 + +D+WS GV + LS G P+ E +A I Sbjct: 192 YEPLGLEADMWSIGVITYILLS-GASPFLGDTKQETLANI 230 >5KKR-C nrPDB Length = 395 Score = 82.8 bits (203), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 63/206 (30%), Positives = 107/206 (51%), Gaps = 25/206 (12%) Query: 343 ELGCGNFGSVRQGVYR-----MRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPY 397 ELG GN G V + ++ M +K I + IK A +++RE Q++H+ ++PY Sbjct: 75 ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIK-------PAIRNQIIRELQVLHECNSPY 127 Query: 398 IVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 IV G ++ + + ME GG L + L K IP + ++ V G+ YL EK+ Sbjct: 128 IVGFYGAFYSDGEISICMEHMDGGSLDQVL-KKAGRIPEQILGKVSIAVIKGLTYLREKH 186 Query: 457 -FVHRDLAARNVLLVNRHYAKISDFGLSKAL--GADDSYYTARSAGKWPLKWYAPECINF 513 +HRD+ N+L+ +R K+ DFG+S L +S+ RS + +PE + Sbjct: 187 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS-------YMSPERLQG 239 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKP 539 +S +SD+WS G+++ E ++ G+ P Sbjct: 240 THYSVQSDIWSMGLSLVE-MAVGRYP 264 >2YZA-A nrPDB Length = 276 Score = 82.0 bits (201), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 70/218 (32%), Positives = 104/218 (47%), Gaps = 16/218 (7%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTE-EMMREAQIMHQLDNPYIVRL 401 LG G FG V+ G +++ + VA+K+L +Q D ++ RE Q + +P+I++L Sbjct: 19 LGVGTFGKVKIGEHQLTGHK--VAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKL 76 Query: 402 IGVCQAEA-LMLVMEMAGGGPLHKFLV--GKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 V +VME GG L ++ G+ EE+ L Q+ + Y V Sbjct: 77 YQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEM---EARRLFQQILSAVDYCHRHMVV 133 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 HRDL NVLL AKI+DFGLS + D + S G P + APE I+ R ++ Sbjct: 134 HRDLKPENVLLDAHMNAKIADFGLSNMMS--DGEFLRDSCGS-P-NYAAPEVISGRLYAG 189 Query: 519 -RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG 555 D+WS GV ++ AL G P+ P + I G Sbjct: 190 PEVDIWSCGVILY-ALLCGTLPFDDEHVPTLFKKIRGG 226 >2J90-A nrPDB Length = 304 Score = 82.0 bits (201), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 57/208 (27%), Positives = 104/208 (50%), Gaps = 18/208 (8%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQ-----GTEKADTEEMMREAQIMHQLDNPY 397 ELG G F VR+ R + + A K +K+ EE+ RE I+ ++ +P Sbjct: 33 ELGSGQFAIVRK--CRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPN 90 Query: 398 IVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 I+ L + + + ++L++E+ GG L FL ++E + + L Q+ G+ YL K Sbjct: 91 IITLHDIFENKTDVVLILELVSGGELFDFL-AEKESLTEDEATQFLKQILDGVHYLHSKR 149 Query: 457 FVHRDLAARNVLLVNRHY----AKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN 512 H DL N++L++++ K+ DFG++ + A + + ++ P ++ APE +N Sbjct: 150 IAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEF---KNIFGTP-EFVAPEIVN 205 Query: 513 FRKFSSRSDVWSYGVTMWEALSYGQKPY 540 + +D+WS GV + LS G P+ Sbjct: 206 YEPLGLEADMWSIGVITYILLS-GASPF 232 >3LIJ-A nrPDB Length = 494 Score = 82.0 bits (201), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 67/226 (29%), Positives = 113/226 (50%), Gaps = 14/226 (6%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 +LG G +G V + R + ++ AIK++ K + +++ E ++ LD+P I++L Sbjct: 44 KLGSGAYGEVL--LCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLDHPNIMKL 101 Query: 402 IGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 + + LVME GG L ++ R + + A ++ QV G+ YL + N VHR Sbjct: 102 YDFFEDKRNYYLVMECYKGGELFDEII-HRMKFNEVDAAVIIKQVLSGVTYLHKHNIVHR 160 Query: 461 DLAARNVLLVNRH---YAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFS 517 DL N+LL ++ KI DFGLS A+ + R + + APE + +K+ Sbjct: 161 DLKPENLLLESKEKDALIKIVDFGLS-AVFENQKKMKERLGTAY---YIAPEVLR-KKYD 215 Query: 518 SRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE 563 + DVWS GV ++ L+ G P+ E++ +E+GK PE Sbjct: 216 EKCDVWSIGVILFILLA-GYPPFGGQTDQEILRKVEKGKYTFDSPE 260 >3EQC-A nrPDB Length = 360 Score = 81.6 bits (200), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 63/206 (30%), Positives = 107/206 (51%), Gaps = 25/206 (12%) Query: 343 ELGCGNFGSVRQGVYR-----MRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPY 397 ELG GN G V + ++ M +K I + IK A +++RE Q++H+ ++PY Sbjct: 40 ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIK-------PAIRNQIIRELQVLHECNSPY 92 Query: 398 IVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 IV G ++ + + ME GG L + L K IP + ++ V G+ YL EK+ Sbjct: 93 IVGFYGAFYSDGEISICMEHMDGGSLDQVL-KKAGRIPEQILGKVSIAVIKGLTYLREKH 151 Query: 457 -FVHRDLAARNVLLVNRHYAKISDFGLSKAL--GADDSYYTARSAGKWPLKWYAPECINF 513 +HRD+ N+L+ +R K+ DFG+S L +S+ RS + +PE + Sbjct: 152 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS-------YMSPERLQG 204 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKP 539 +S +SD+WS G+++ E ++ G+ P Sbjct: 205 THYSVQSDIWSMGLSLVE-MAVGRYP 229 >6CTH-A nrPDB Length = 309 Score = 81.6 bits (200), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 61/217 (28%), Positives = 105/217 (48%), Gaps = 9/217 (4%) Query: 340 ADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIV 399 A+ +LG G FGSV +G +R +A+K + + + K +E E +I+ +L + +V Sbjct: 19 AENKLGEGGFGSVYRGF--LRDSDTYIAVKKVSRAS-KQGIKEYASEVKIISRLRHKNLV 75 Query: 400 RLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN-- 456 +LIG C LMLV E G L + + + ++ ++ + YL E+ Sbjct: 76 KLIGWCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHEEGDH 135 Query: 457 -FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK 515 +HRD+ N++L + AK+ DFGL++ + AG + + APEC++ K Sbjct: 136 CVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAG--TVGYMAPECLSSGK 193 Query: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI 552 S SDV+S+GV E S + K + E + + Sbjct: 194 ASKESDVYSFGVVALEIASGRRSIEPKFEESEALLLV 230 >1FOT-A nrPDB Length = 318 Score = 81.6 bits (200), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 61/207 (29%), Positives = 103/207 (49%), Gaps = 27/207 (13%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD--------- 394 LG G+FG V + R R A+KVLK+ E ++R Q+ H D Sbjct: 14 LGTGSFGRVH--LIRSRHNGRYYAMKVLKK-------EIVVRLKQVEHTNDERLMLSIVT 64 Query: 395 NPYIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 +P+I+R+ G Q A+ + ++M+ GG L L+ K + P +V + ++YL Sbjct: 65 HPFIIRMWGTFQDAQQIFMIMDYIEGGELFS-LLRKSQRFPNPVAKFYAAEVCLALEYLH 123 Query: 454 EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF 513 K+ ++RDL N+LL + KI+DFG +K + D YT + APE ++ Sbjct: 124 SKDIIYRDLKPENILLDKNGHIKITDFGFAKYVP--DVTYTLCGTP----DYIAPEVVST 177 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPY 540 + ++ D WS+G+ ++E L+ G P+ Sbjct: 178 KPYNKSIDWWSFGILIYEMLA-GYTPF 203 >3DXN-A nrPDB Length = 287 Score = 81.6 bits (200), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 68/230 (29%), Positives = 117/230 (50%), Gaps = 21/230 (9%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG--TEKADTEEMMREAQIMHQLDNPYIVR 400 +LG G +G V + + + + AIK++K+ T +++ ++ E ++ QLD+P I++ Sbjct: 28 KLGSGAYGEVL--LCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPNIMK 85 Query: 401 LIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 L + + LVME+ GG L ++ R++ + A ++ QV G YL + N VH Sbjct: 86 LYEFFEDKRNYYLVMEVYRGGELFDEII-LRQKFSEVDAAVIMKQVLSGTTYLHKHNIVH 144 Query: 460 RDLAARNVLLVNRH---YAKISDFGLSKALGADDSYYTARSAGKWPLK---WYAPECINF 513 RDL N+LL ++ KI DFGLS +++ K L + APE + Sbjct: 145 RDLKPENLLLESKSRDALIKIVDFGLS-------AHFEVGGKMKERLGTAYYIAPEVLR- 196 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE 563 +K+ + DVWS GV ++ L G P+ E++ +E+GK PP+ Sbjct: 197 KKYDEKCDVWSCGVILYILLC-GYPPFGGQTDQEILKRVEKGKFSFDPPD 245 >3GUB-A nrPDB Length = 295 Score = 81.3 bits (199), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 60/218 (27%), Positives = 106/218 (48%), Gaps = 18/218 (8%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADT-----EEMMREAQIMHQLDNPY 397 ELG G F V++ R + + A K +K+ K+ E++ RE I+ ++ +P Sbjct: 18 ELGSGQFAVVKKC--REKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPN 75 Query: 398 IVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 ++ L V + + ++L+ E+ GG L FL ++E + E L Q+ G+ YL Sbjct: 76 VITLHEVYENKTDVILIGELVAGGELFDFL-AEKESLTEEEATEFLKQILNGVYYLHSLQ 134 Query: 457 FVHRDLAARNVLLVNRHY----AKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN 512 H DL N++L++R+ KI DFGL+ + + + ++ P ++ APE +N Sbjct: 135 IAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEF---KNIFGTP-EFVAPEIVN 190 Query: 513 FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMA 550 + +D+WS GV + LS G P+ E +A Sbjct: 191 YEPLGLEADMWSIGVITYILLS-GASPFLGDTKQETLA 227 >3HZT-A nrPDB Length = 467 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 68/230 (29%), Positives = 117/230 (50%), Gaps = 21/230 (9%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG--TEKADTEEMMREAQIMHQLDNPYIVR 400 +LG G +G V + + + + AIK++K+ T +++ ++ E ++ QLD+P I++ Sbjct: 11 KLGSGAYGEVL--LCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPNIMK 68 Query: 401 LIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 L + + LVME+ GG L ++ R++ + A ++ QV G YL + N VH Sbjct: 69 LYEFFEDKRNYYLVMEVYRGGELFDEII-LRQKFSEVDAAVIMKQVLSGTTYLHKHNIVH 127 Query: 460 RDLAARNVLLVNRH---YAKISDFGLSKALGADDSYYTARSAGKWPLK---WYAPECINF 513 RDL N+LL ++ KI DFGLS +++ K L + APE + Sbjct: 128 RDLKPENLLLESKSRDALIKIVDFGLS-------AHFEVGGKMKERLGTAYYIAPEVLR- 179 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE 563 +K+ + DVWS GV ++ L G P+ E++ +E+GK PP+ Sbjct: 180 KKYDEKCDVWSCGVILYILLC-GYPPFGGQTDQEILKRVEKGKFSFDPPD 228 >4TPT-A nrPDB Length = 303 Score = 80.9 bits (198), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 72/277 (25%), Positives = 118/277 (42%), Gaps = 35/277 (12%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LG G FG + ++ K + V ++++ E T + E ++M LD+P +++ IG Sbjct: 8 LGKGFFGQAIKVTHKATGK-VMVMKELIRCDEETQKT--FLTEVKVMRSLDHPNVLKFIG 64 Query: 404 VC-QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 V + + L L+ E GG L FL + P ++ GM YL +HRDL Sbjct: 65 VLYKDKKLNLLTEYIEGGTLKDFL-RSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDL 123 Query: 463 AARNVLLVNRHYAKISDFGLSKALG-------ADDSYYTARSAGKWPLK----------W 505 + N L+ ++DFGLS+ + + + R+ K K W Sbjct: 124 NSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYW 183 Query: 506 YAPECINFRKFSSRSDVWSYGVTMWEALSYGQK-------PYKKMKGPEVMAFIEQGKRM 558 APE +N + + D++S+G+ + E + GQ P G V F E+ Sbjct: 184 MAPEMLNGKSYDETVDIFSFGIVLCEII--GQVYADPDCLPRTLDFGLNVKLFWEKF--- 238 Query: 559 ECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRA 595 P +CPP + L + C + E RP F +E A Sbjct: 239 -VPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEA 274 >5TQX-A nrPDB Length = 655 Score = 80.1 bits (196), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 101/209 (48%), Gaps = 20/209 (9%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL-- 401 LG G FG+V +Y+ R+ + +AIK + + E E QIM +L++ +V+ Sbjct: 16 LGTGGFGNV--CLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVVKACD 73 Query: 402 ----IGVCQAEALMLVMEMAGGGPLHKFLVGKREE---IPVSNVAELLHQVSMGMKYLEE 454 + + + +L ME GG L K L+ K E + S + LL + G++YL E Sbjct: 74 VPEELNILIHDVPLLAMEYCSGGDLRK-LLNKPENCCGLKESQILSLLSDIGSGIRYLHE 132 Query: 455 KNFVHRDLAARNVLLVN---RHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI 511 +HRDL N++L + + KI D G +K D G L++ APE Sbjct: 133 NKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAK--DVDQGELCTEFVG--TLQYLAPELF 188 Query: 512 NFRKFSSRSDVWSYGVTMWEALSYGQKPY 540 + +++ D WS+G ++E ++ G +P+ Sbjct: 189 ENKPYTATVDYWSFGTMVFECIA-GYRPF 216 >2A1A-B nrPDB Length = 284 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 62/220 (28%), Positives = 103/220 (46%), Gaps = 30/220 (13%) Query: 333 KRDNLLIADIEL-GCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMH 391 KR + +IEL G G FG V + +R+ K IK +K EKA+ RE + + Sbjct: 7 KRFGMDFKEIELIGSGGFGQVFKAKHRIDGKT--YVIKRVKYNNEKAE-----REVKALA 59 Query: 392 QLDNPYIVRLIGV-----------------CQAEALMLVMEMAGGGPLHKFLVGKR-EEI 433 +LD+ IV G + + L + ME G L +++ +R E++ Sbjct: 60 KLDHVNIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKL 119 Query: 434 PVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYY 493 EL Q++ G+ Y+ K ++RDL N+ LV+ KI DFGL +L D Sbjct: 120 DKVLALELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKND---- 175 Query: 494 TARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEAL 533 R+ K L++ +PE I+ + + D+++ G+ + E L Sbjct: 176 GKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL 215 >6J5U-C nrPDB Length = 426 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 70/226 (30%), Positives = 112/226 (49%), Gaps = 25/226 (11%) Query: 323 EELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRK-------KQIDVAIKVLK-QG 374 ELK+ ++DNLL G G FG V +G I VA+K LK +G Sbjct: 77 NELKNATKNFRQDNLL------GEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEG 130 Query: 375 TEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEI 433 + +E + E + QL +P +V L+G C + E +LV E G L L +R Sbjct: 131 FQ--GHKEWLTEVNYLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLF-RRGAQ 187 Query: 434 PVSNVAELLHQV--SMGMKYLEE--KNFVHRDLAARNVLLVNRHYAKISDFGLSKAL-GA 488 P++ + V + G+ +L E ++RD A N+LL AK+SDFGL+KA Sbjct: 188 PLTWAIRMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTG 247 Query: 489 DDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALS 534 D+++ + + G + APE + + +++SDV+S+GV + E +S Sbjct: 248 DNTHVSTKVIGTH--GYAAPEYVATGRLTAKSDVYSFGVVLLELIS 291 >5XZW-A nrPDB Length = 471 Score = 79.3 bits (194), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 73/278 (26%), Positives = 125/278 (44%), Gaps = 28/278 (10%) Query: 303 DKPRPMPMDTSVYESP---YSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRM 359 D+ R +TS SP S + K + +D +I ++ +G G F +V++ + R Sbjct: 161 DRIRSNLKNTSKIASPGLTSSTASSMVANKTGIFKDFSIIDEV-VGQGAFATVKKAIERT 219 Query: 360 RKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQ-AEALMLVMEMAG 418 K A+K++ + + + + RE +++ +L++P IVRL G + E+ +VME Sbjct: 220 TGKTF--AVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGFYEDTESYYMVMEFVS 277 Query: 419 GGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRH--YAK 476 GG L F V + E+ Q+ +KY+ HRDL N+L+ K Sbjct: 278 GGDLMDF-VAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDPVLVK 336 Query: 477 ISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR-------------KFSSRSDVW 523 I+DFGL+K G + + G L + APE I + ++SS D+W Sbjct: 337 ITDFGLAKVQG--NGSFMKTFCG--TLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMW 392 Query: 524 SYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECP 561 S G ++ L+ G P+ ++ I +G E P Sbjct: 393 SMGCLVYVILT-GHLPFSGSTQDQLYKQIGRGSYHEGP 429 >5B2L-A nrPDB Length = 324 Score = 79.3 bits (194), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 77/261 (29%), Positives = 122/261 (46%), Gaps = 31/261 (11%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQI-MHQLDNPYIVRL 401 E+G G G V + R RK +A+K +++ K + + ++ + + + D PYIV+ Sbjct: 24 EMGSGTCGQVWK--MRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQC 81 Query: 402 IGVCQAEA-LMLVMEMAGGGP--LHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN-F 457 G + + ME+ G L K + G IP + ++ + + YL+EK+ Sbjct: 82 FGTFITNTDVFIAMELMGTSAEKLKKRMQG---PIPERILGKMTVAIVKALYYLKEKHGV 138 Query: 458 VHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN----- 512 +HRD+ N+LL R K+ DFG+S L DS RSAG + APE I+ Sbjct: 139 IHRDVKPSNILLDERGQIKLCDFGISGRLV--DSKAKTRSAG--CAAYMAPERIDPPDPT 194 Query: 513 FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP-EVMAFIEQGKRMECPPECP------ 565 + R+DVWS G+++ E L+ GQ PYK K EV+ + Q E PP P Sbjct: 195 KPDYDIRADVWSLGISLVE-LATGQFPYKNCKTDFEVLTKVLQ----EEPPLLPGHMGFS 249 Query: 566 PELYALMSDCWIYKWEDRPDF 586 + + + DC RP + Sbjct: 250 GDFQSFVKDCLTKDHRKRPKY 270 >4YNZ-A nrPDB Length = 342 Score = 79.3 bits (194), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 65/234 (27%), Positives = 115/234 (49%), Gaps = 16/234 (6%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMM---REAQIMHQLDNPYIVR 400 LG G G V+ G++ + ++ VAIK++ + EK +M RE I+ +++P++++ Sbjct: 18 LGKGQTGLVKLGIHCVTCQK--VAIKIVNR--EKLSESVLMKVEREIAILKLIEHPHVLK 73 Query: 401 LIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 L V + + L LV+E GG L +LV K P + Q+ + + + H Sbjct: 74 LHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTP-KEARKFFRQIISALDFCHSHSICH 132 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 519 RDL N+LL R+ +I+DFG++ D T+ + + PE I K+ R Sbjct: 133 RDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYA----CPEVIRGEKYDGR 188 Query: 520 -SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALM 572 +DVWS GV ++ AL G P+ +++ +++G P PP+ +L+ Sbjct: 189 KADVWSCGVILF-ALLVGALPFDDDNLRQLLEKVKRGV-FHMPHFIPPDCQSLL 240 >4JXF-A nrPDB Length = 266 Score = 79.0 bits (193), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 62/203 (30%), Positives = 97/203 (47%), Gaps = 15/203 (7%) Query: 344 LGCGNFGSVRQGVYRMRKKQ--IDVAIKVL-KQGTEKAD-TEEMMREAQIMHQLDNPYIV 399 LG G+F GVYR ++VAIK++ K+ KA + + E +I QL +P I+ Sbjct: 15 LGKGSFA----GVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSIL 70 Query: 400 RLIGVCQ-AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 L + + + LV+EM G ++++L + + + +HQ+ GM YL + Sbjct: 71 ELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGIL 130 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKALGA-DDSYYTARSAGKWPLKWYAPECINFRKFS 517 HRDL N+LL KI+DFGL+ L + +YT + +PE Sbjct: 131 HRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTP----NYISPEIATRSAHG 186 Query: 518 SRSDVWSYGVTMWEALSYGQKPY 540 SDVWS G M+ L G+ P+ Sbjct: 187 LESDVWSLG-CMFYTLLIGRPPF 208 >4D2V-A nrPDB Length = 356 Score = 79.0 bits (193), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 55/215 (25%), Positives = 101/215 (46%), Gaps = 8/215 (3%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G G F V+ + + + VAIK++ + T +D + E + + L + +I +L Sbjct: 37 IGTGGFAKVKLACHILTGEM--VAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYH 94 Query: 404 VCQ-AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 V + A + +V+E GG L +++ + + + + Q+ + Y+ + + HRDL Sbjct: 95 VLETANKIFMVLEYCPGGELFDYIISQ-DRLSEEETRVVFRQIVSAVAYVHSQGYAHRDL 153 Query: 463 AARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKF-SSRSD 521 N+L H K+ DFGL + Y+ G L + APE I + + S +D Sbjct: 154 KPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCG--ALAYAAPELIQGKSYLGSEAD 211 Query: 522 VWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK 556 VWS G+ ++ L G P+ ++A I +GK Sbjct: 212 VWSMGILLY-VLMCGFLPFDDDTAAALVAKIMRGK 245 >1ZWS-A nrPDB Length = 288 Score = 78.6 bits (192), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 61/220 (27%), Positives = 107/220 (48%), Gaps = 18/220 (8%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADT-----EEMMREAQIMHQLDNPY 397 ELG G F V++ R + ++ A K +K+ +A EE+ RE I+ Q+ + Sbjct: 19 ELGSGQFAIVKKC--REKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHN 76 Query: 398 IVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 ++ L V + ++L++E+ GG L FL ++E + + Q+ G+ YL K Sbjct: 77 VITLHDVYENRTDVVLILELVSGGELFDFL-AQKESLSEEEATSFIKQILDGVNYLHTKK 135 Query: 457 FVHRDLAARNVLLVNRH----YAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN 512 H DL N++L++++ + K+ DFGL+ + +D G P ++ APE +N Sbjct: 136 IAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEI--EDGVEFKNIFGT-P-EFVAPEIVN 191 Query: 513 FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI 552 + +D+WS GV + LS G P+ E +A I Sbjct: 192 YEPLGLEADMWSIGVITYILLS-GASPFLGDTKQETLANI 230 >2A27-A nrPDB Length = 321 Score = 78.6 bits (192), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 61/220 (27%), Positives = 107/220 (48%), Gaps = 18/220 (8%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADT-----EEMMREAQIMHQLDNPY 397 ELG G F V++ R + ++ A K +K+ +A EE+ RE I+ Q+ + Sbjct: 19 ELGSGQFAIVKKC--REKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHN 76 Query: 398 IVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 ++ L V + ++L++E+ GG L FL ++E + + Q+ G+ YL K Sbjct: 77 VITLHDVYENRTDVVLILELVSGGELFDFL-AQKESLSEEEATSFIKQILDGVNYLHTKK 135 Query: 457 FVHRDLAARNVLLVNRH----YAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN 512 H DL N++L++++ + K+ DFGL+ + +D G P ++ APE +N Sbjct: 136 IAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEI--EDGVEFKNIFGT-P-EFVAPEIVN 191 Query: 513 FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI 552 + +D+WS GV + LS G P+ E +A I Sbjct: 192 YEPLGLEADMWSIGVITYILLS-GASPFLGDTKQETLANI 230 >4L42-A nrPDB Length = 346 Score = 78.2 bits (191), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 69/232 (29%), Positives = 111/232 (47%), Gaps = 19/232 (8%) Query: 344 LGCGNFGSVRQ--GVYRMRKKQIDVAIKVLKQGT---EKADTEEMMREAQIMHQLDNPYI 398 LG G +G V Q V +I A+KVLK+ DT E I+ ++ +P+I Sbjct: 26 LGKGGYGKVFQVRKVTGANTGKI-FAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFI 84 Query: 399 VRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAEL-LHQVSMGMKYLEEKN 456 V LI Q L L++E GG L F+ +RE I + + A L ++SM + +L +K Sbjct: 85 VDLIYAFQTGGKLYLILEYLSGGEL--FMQLEREGIFMEDTACFYLAEISMALGHLHQKG 142 Query: 457 FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKF 516 ++RDL N++L ++ + K++DFGL K D T G +++ APE + Sbjct: 143 IIYRDLKPENIMLNHQGHVKLTDFGLCKE-SIHDGTVTHTFCG--TIEYMAPEILMRSGH 199 Query: 517 SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPEL 568 + D WS G M++ L+ G P+ + + K ++C PP L Sbjct: 200 NRAVDWWSLGALMYDMLT-GAPPFTGENRKKTI-----DKILKCKLNLPPYL 245 >3QA8-A nrPDB Length = 676 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 64/213 (30%), Positives = 100/213 (46%), Gaps = 27/213 (12%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVR--- 400 LG G FG V + +++ +Q VAIK +Q + E E QIM +L++P +V Sbjct: 22 LGTGGFGYVLRWIHQDTGEQ--VAIKQCRQELSPKNRERWCLEIQIMKKLNHPNVVSARE 79 Query: 401 ----LIGVCQAEALMLVMEMAGGGPLHKFL------VGKREEIPVSNVAELLHQVSMGMK 450 L + + +L ME GG L K+L G +E + LL +S ++ Sbjct: 80 VPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKE----GPIRTLLSDISSALR 135 Query: 451 YLEEKNFVHRDLAARNVLLV---NRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYA 507 YL E +HRDL N++L R KI D G +K L D G L++ A Sbjct: 136 YLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKEL--DQGELCTEFVGT--LQYLA 191 Query: 508 PECINFRKFSSRSDVWSYGVTMWEALSYGQKPY 540 PE + +K++ D WS+G +E ++ G +P+ Sbjct: 192 PELLEQKKYTVTVDYWSFGTLAFECIT-GFRPF 223 >4UZD-A nrPDB Length = 287 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 78/262 (29%), Positives = 120/262 (45%), Gaps = 31/262 (11%) Query: 344 LGCGNFGSVRQGVYRMRKKQ--IDVAIKVL-KQGTEKADTE-EMMREAQIMHQLDNPYIV 399 LG G FG+V Y R+KQ +A+KVL K EKA E ++ RE +I L +P I+ Sbjct: 16 LGKGKFGNV----YLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNIL 71 Query: 400 RLIGVCQ-AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 RL G A + L++E A G +++ L K + A + +++ + Y K + Sbjct: 72 RLYGYFHDATRVYLILEYAPLGTVYREL-QKLSKFDEQRTATYITELANALSYCHSKRVI 130 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 HRD+ N+LL + KI+DFG S + A S T L + PE I R Sbjct: 131 HRDIKPENLLLGSAGELKIADFGWS--VHAPSSRRTTLCG---TLDYLPPEMIEGRMHDE 185 Query: 519 RSDVWSYGVTMWEAL--------SYGQKPYKKMKGPEVM--AFIEQGKR------MECPP 562 + D+WS GV +E L + Q+ YK++ E F+ +G R ++ P Sbjct: 186 KVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNP 245 Query: 563 ECPPELYALMSDCWIYKWEDRP 584 P L ++ WI +P Sbjct: 246 SQRPMLREVLEHPWITANSSKP 267 >4RLP-A nrPDB Length = 288 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 69/232 (29%), Positives = 111/232 (47%), Gaps = 19/232 (8%) Query: 344 LGCGNFGSVRQ--GVYRMRKKQIDVAIKVLKQGT---EKADTEEMMREAQIMHQLDNPYI 398 LG G +G V Q V +I A+KVLK+ DT E I+ ++ +P+I Sbjct: 13 LGKGGYGKVFQVRKVTGANTGKI-FAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFI 71 Query: 399 VRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAEL-LHQVSMGMKYLEEKN 456 V LI Q L L++E GG L F+ +RE I + + A L ++SM + +L +K Sbjct: 72 VDLIYAFQTGGKLYLILEYLSGGEL--FMQLEREGIFMEDTACFYLAEISMALGHLHQKG 129 Query: 457 FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKF 516 ++RDL N++L ++ + K++DFGL K D T G +++ APE + Sbjct: 130 IIYRDLKPENIMLNHQGHVKLTDFGLCKE-SIHDGTVTHTFCG--TIEYMAPEILMRSGH 186 Query: 517 SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPEL 568 + D WS G M++ L+ G P+ + + K ++C PP L Sbjct: 187 NRAVDWWSLGALMYDMLT-GAPPFTGENRKKTI-----DKILKCKLNLPPYL 232 >5XD6-A nrPDB Length = 305 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 77/281 (27%), Positives = 133/281 (47%), Gaps = 39/281 (13%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G G++G V G+ + K A + K + K +E + + ++ +L +V L+G Sbjct: 30 IGEGSYGRVFYGILKSGK-----AAAIKKLDSSKQPDQEFLAQVSMVSRLRQENVVALLG 84 Query: 404 VCQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAELL--HQ-------VSMGMKYLE 453 C L +L E A G LH L G R+ + + +L HQ + G++YL Sbjct: 85 YCVDGPLRVLAYEYAPNGSLHDILHG-RKGVKGAQPGPVLSWHQRVKIAVGAARGLEYLH 143 Query: 454 EK---NFVHRDLAARNVLLVNRHYAKISDFGLS-KALGADDSYYTARSAGKWPLKWYAPE 509 EK + +HRD+ + NVLL + AKI+DF LS +A ++ R G + ++APE Sbjct: 144 EKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTF--GYHAPE 201 Query: 510 CINFRKFSSRSDVWSYGVTMWEALSYGQKPYK----------------KMKGPEVMAFIE 553 S++SDV+S+GV + E L+ G+KP K+ +V ++ Sbjct: 202 YAMTGTLSTKSDVYSFGVVLLELLT-GRKPVDHTLPRGQQSVVTWATPKLSEDKVKQCVD 260 Query: 554 QGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMR 594 E PP+ +L A+ + C Y+ + RP+ V + ++ Sbjct: 261 ARLNGEYPPKAVAKLAAVAALCVQYEADFRPNMSIVVKALQ 301 >3UIU-A nrPDB Length = 306 Score = 77.4 bits (189), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 62/233 (26%), Positives = 103/233 (44%), Gaps = 43/233 (18%) Query: 333 KRDNLLIADIEL-GCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMH 391 KR + +IEL G G FG V + +R+ K I+ +K EKA+ RE + + Sbjct: 8 KRFGMDFKEIELIGSGGFGQVFKAKHRIDGKT--YVIRRVKYNNEKAE-----REVKALA 60 Query: 392 QLDNPYIVRLIGV------------------------------CQAEALMLVMEMAGGGP 421 +LD+ IV G + + L + ME G Sbjct: 61 KLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGT 120 Query: 422 LHKFLVGKR-EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDF 480 L +++ +R E++ EL Q++ G+ Y+ K +HRDL N+ LV+ KI DF Sbjct: 121 LEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDF 180 Query: 481 GLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEAL 533 GL +L D R+ K L++ +PE I+ + + D+++ G+ + E L Sbjct: 181 GLVTSLKND----GKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL 229 >2UV2-A nrPDB Length = 325 Score = 77.4 bits (189), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 57/197 (28%), Positives = 93/197 (47%), Gaps = 16/197 (8%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDV--AIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVR 400 ELG G FG V Y+ + K+ V A KV+ +E+ + E+ M E I+ D+P IV+ Sbjct: 44 ELGDGAFGKV----YKAQNKETSVLAAAKVIDTKSEE-ELEDYMVEIDILASCDHPNIVK 98 Query: 401 LIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 L+ E L +++E GG + ++ + S + + Q + YL + +H Sbjct: 99 LLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIH 158 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-----NFR 514 RDL A N+L K++DFG+S + R + W APE + R Sbjct: 159 RDLKAGNILFTLDGDIKLADFGVS---AKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDR 215 Query: 515 KFSSRSDVWSYGVTMWE 531 + ++DVWS G+T+ E Sbjct: 216 PYDYKADVWSLGITLIE 232 >2X4F-A nrPDB Length = 373 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 59/203 (29%), Positives = 100/203 (49%), Gaps = 17/203 (8%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LG G FG V + + +A K++K K D EE+ E +M+QLD+ +++L Sbjct: 97 LGGGRFGQVHK--CEETATGLKLAAKIIKTRGMK-DKEEVKNEISVMNQLDHANLIQLYD 153 Query: 404 VCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 +++ ++LVME GG L ++ + + + + Q+ G++++ + +H DL Sbjct: 154 AFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDL 213 Query: 463 AARNVLLVNR--HYAKISDFGLSKALGADDSYYTARSAGKWPL---KWYAPECINFRKFS 517 N+L VNR KI DFGL++ Y R K ++ APE +N+ S Sbjct: 214 KPENILCVNRDAKQIKIIDFGLARR-------YKPREKLKVNFGTPEFLAPEVVNYDFVS 266 Query: 518 SRSDVWSYGVTMWEALSYGQKPY 540 +D+WS GV + LS G P+ Sbjct: 267 FPTDMWSVGVIAYMLLS-GLSPF 288 >4RGJ-A nrPDB Length = 520 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 63/221 (28%), Positives = 110/221 (49%), Gaps = 18/221 (8%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVL--KQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 LG G+FG V + R + + AIKV+ K K D E ++RE +++ LD+ I++L Sbjct: 68 LGKGSFGEVI--LSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHINIMKL 125 Query: 402 IGVCQAEALM-LVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 + LV ++ GG L ++ ++ + + A ++ Q+ G+ Y+ + N VHR Sbjct: 126 YEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEI-DAARIIKQILSGITYMHKNNVVHR 184 Query: 461 DLAARNVLLVNRH----YAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APECINFRK 515 DL N+LL ++ KI DFGLS Y+ + K +Y AP+ ++ Sbjct: 185 DLKPENILLETKNKEDMIIKIIDFGLSTHFE-----YSKKMKDKIGTAYYIAPDVLH-GT 238 Query: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK 556 + + D+WS GV ++ LS G P+ +++ +E GK Sbjct: 239 YDEKCDIWSCGVILYILLS-GCPPFNGSNEYDILKKVEAGK 278 >2BPM-A nrPDB Length = 309 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 58/198 (29%), Positives = 95/198 (47%), Gaps = 14/198 (7%) Query: 343 ELGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADT-EEMMREAQIMHQLDNPYIV 399 ++G G +G V Y+ R K VA+K ++ TE +RE ++ +L++P IV Sbjct: 14 KIGEGTYGVV----YKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIV 69 Query: 400 RLIGVCQAE-ALMLVMEMAGGGPLHKFL-VGKREEIPVSNVAELLHQVSMGMKYLEEKNF 457 +L+ V E L LV E L KF+ IP+ + L Q+ G+ + Sbjct: 70 KLLDVIHTENKLYLVFEFLHQD-LKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 128 Query: 458 VHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC-INFRKF 516 +HRDL +N+L+ K++DFGL++A G YT W + APE + + + Sbjct: 129 LHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLW---YRAPEILLGCKYY 185 Query: 517 SSRSDVWSYGVTMWEALS 534 S+ D+WS G E ++ Sbjct: 186 STAVDIWSLGCIFAEMVT 203 >4FR4-A nrPDB Length = 384 Score = 76.6 bits (187), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 62/204 (30%), Positives = 100/204 (49%), Gaps = 16/204 (7%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G G+FG V KK + ++ E+ + + +E QIM L++P++V L Sbjct: 23 IGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEHPFLVNLWY 82 Query: 404 VCQAEA-LMLVMEMAGGGPLHKFL---VGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 Q E + +V+++ GG L L V +EE + EL+ M + YL+ + +H Sbjct: 83 SFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELV----MALDYLQNQRIIH 138 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK---F 516 RD+ N+LL + I+DF ++ L + T AG P + APE + RK + Sbjct: 139 RDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTM--AGTKP--YMAPEMFSSRKGAGY 194 Query: 517 SSRSDVWSYGVTMWEALSYGQKPY 540 S D WS GVT +E L G++PY Sbjct: 195 SFAVDWWSLGVTAYELLR-GRRPY 217 >6HXF-B nrPDB Length = 302 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 56/201 (27%), Positives = 98/201 (48%), Gaps = 24/201 (11%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDV--AIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVR 400 ELG G FG V Y+ + K+ A KV++ +E+ + E+ + E +I+ D+PYIV+ Sbjct: 26 ELGDGAFGKV----YKAKNKETGALAAAKVIETKSEE-ELEDYIVEIEILATCDHPYIVK 80 Query: 401 LIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 L+G + L +++E GG + ++ + + + Q+ + +L K +H Sbjct: 81 LLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIH 140 Query: 460 RDLAARNVLLVNRHYAKISDFGLS----KALGADDSYYTARSAGKWPLKWYAPECINFRK 515 RDL A NVL+ +++DFG+S K L DS+ W APE + Sbjct: 141 RDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPY-------WMAPEVVMCET 193 Query: 516 -----FSSRSDVWSYGVTMWE 531 + ++D+WS G+T+ E Sbjct: 194 MKDTPYDYKADIWSLGITLIE 214 >4KRC-A nrPDB Length = 317 Score = 76.3 bits (186), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 56/199 (28%), Positives = 98/199 (49%), Gaps = 13/199 (6%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 +LG G + +V +G+ + + VA+K +K +E+ +RE +M +L + IVRL Sbjct: 12 KLGNGTYATVYKGLNK--TTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLY 69 Query: 403 GVCQAE-ALMLVMEMAGGGPLHKFL----VGKREEIPVSNVAELLH-QVSMGMKYLEEKN 456 V E L LV E L K++ VG N+ + Q+ G+ + E Sbjct: 70 DVIHTENKLTLVFEFMDND-LKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 Query: 457 FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRK 515 +HRDL +N+L+ R K+ DFGL++A G + +++ W + AP+ + R Sbjct: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLW---YRAPDVLMGSRT 185 Query: 516 FSSRSDVWSYGVTMWEALS 534 +S+ D+WS G + E ++ Sbjct: 186 YSTSIDIWSCGCILAEMIT 204 >6BDL-A nrPDB Length = 347 Score = 75.9 bits (185), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 68/221 (30%), Positives = 102/221 (46%), Gaps = 14/221 (6%) Query: 332 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG--TEKADTEEMMREAQI 389 LK + I D LG G FG V + V ++ A+K+LK+ + E + E QI Sbjct: 31 LKLSDFNIIDT-LGVGGFGRV-ELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQI 88 Query: 390 MHQLDNPYIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMG 448 M + +IVRL + ++ L ++ME GG L L R S V Sbjct: 89 MQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILR-DRGSFEDSTTRFYTACVVEA 147 Query: 449 MKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 YL K ++RDL N++L +R YAK+ DFG +K +G +T ++ AP Sbjct: 148 FAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTP----EYVAP 203 Query: 509 ECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVM 549 E I + +D WS G+ M+E L+ G P+ GP+ M Sbjct: 204 EIILNKGHDISADYWSLGILMYELLT-GSPPF---SGPDPM 240 >3D2K-A nrPDB Length = 272 Score = 75.9 bits (185), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 65/201 (32%), Positives = 99/201 (49%), Gaps = 12/201 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTE-EMMREAQIMHQLDNPYIVRL 401 LG G FG+V + R R+ + +A+KVL K EKA E ++ RE +I L +P I+RL Sbjct: 20 LGKGKFGNVY--LARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRHPNILRL 77 Query: 402 IGVCQ-AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 G A + L++E A G +++ L K A + +++ + Y K +HR Sbjct: 78 YGYFHDATRVYLILEYAPLGTVYREL-QKLSRFDEQRTATYITELANALSYCHSKRVIHR 136 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRS 520 D+ N+LL + KI+DFG S + A S T L + PE I R + Sbjct: 137 DIKPENLLLGSNGELKIADFGWS--VHAPSSRRTTLCG---TLDYLPPEMIEGRMHDEKV 191 Query: 521 DVWSYGVTMWEALSYGQKPYK 541 D+WS GV +E L G P++ Sbjct: 192 DLWSLGVLCYEFL-VGMPPFE 211 >5YKS-A nrPDB Length = 377 Score = 75.5 bits (184), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 62/236 (26%), Positives = 112/236 (47%), Gaps = 24/236 (10%) Query: 341 DIELGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTEEMMREAQIMHQLDNPYIV 399 D LG G+F V+ + ++ VA+KV+ K + T + +E + M + +P IV Sbjct: 40 DKTLGRGHFAVVKLARHVFTGEK--VAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIV 97 Query: 400 RLIGVCQAEA-LMLVMEMAGGGPLHKFLV----GKREEIPVSNVAELLHQVSMGMKYLEE 454 RL V + L L++E+ GG + +++ G E++ A+++H +S Y + Sbjct: 98 RLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAIS----YCHK 153 Query: 455 KNFVHRDLAARNVLLVNRH-YAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF 513 + VHRDL NV+ + K++DFG S T+ + L + APE + Sbjct: 154 LHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGS----LAYSAPEILLG 209 Query: 514 RKFSSRS-DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPEL 568 ++ + + D+WS GV ++ L GQ P+++ E + I M+C P + Sbjct: 210 DEYDAPAVDIWSLGVILF-MLVCGQPPFQEANDSETLTMI-----MDCKYTVPSHV 259 >4M69-B nrPDB Length = 283 Score = 75.1 bits (183), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 58/263 (22%), Positives = 130/263 (49%), Gaps = 18/263 (6%) Query: 356 VYRMRKKQIDVAIKVLKQGTEKADTEEMMR-----EAQIMHQLDNPYIVRLIGVCQAEAL 410 +YR + V IKV +A++ ++R E + M + D+P I+R+ G+C + + Sbjct: 25 IYRGEYHRSPVTIKVF--NNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTV 82 Query: 411 M-----LVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAAR 465 +VME G L + L+ + +++ +S + L+ + + G+ L +HR++++ Sbjct: 83 KPPEFSIVMEYCELGTLRE-LLDREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSS 141 Query: 466 NVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APECIN--FRKFSSRSDV 522 + L+ + K++ F LSK + + A + Y +PE + F + ++++ Sbjct: 142 SFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEI 201 Query: 523 WSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRME-CPPECPPELYALMSDCWIYKWE 581 +S+G+ +WE ++ G+ P++ ++ + + K+ E +CP L ++++C ++ Sbjct: 202 YSFGIVLWE-IATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPS 260 Query: 582 DRPDFLTVEQRMRACYYSLASKV 604 RP + +R+ A S KV Sbjct: 261 QRPSVDGILERLSAVEESTDKKV 283 >4PDS-A nrPDB Length = 347 Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 63/242 (26%), Positives = 109/242 (45%), Gaps = 24/242 (9%) Query: 336 NLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN 395 + I D +G G F +V++ + R K ++K++ + + + + RE +++ +L++ Sbjct: 31 DFSIIDEVVGQGAFATVKKAIERTTGKTF--SVKIISKRKVIGNMDGVTRELEVLQKLNH 88 Query: 396 PYIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 454 P IVRL G + E+ +VME GG L F V + E+ Q+ +KY+ Sbjct: 89 PRIVRLKGFYEDTESYYMVMEFVSGGDLMDF-VAAHGAVGEDAGREISRQILTAIKYIHS 147 Query: 455 KNFVHRDLAARNVLLVNRH--YAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN 512 HRDL N+L+ KI+ FGL+K G + + G L + APE I Sbjct: 148 MGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQG--NGSFMKTFCG--TLAYVAPEVIR 203 Query: 513 FR-------------KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRME 559 + ++SS D+WS G ++ L+ G P+ ++ I +G E Sbjct: 204 GKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILT-GHLPFSGSTQDQLYKQIGRGSYHE 262 Query: 560 CP 561 P Sbjct: 263 GP 264 >3KK8-A nrPDB Length = 284 Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 61/219 (27%), Positives = 109/219 (49%), Gaps = 15/219 (6%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKA-DTEEMMREAQIMHQLDNPYIVRL 401 ELG G F VR+ V++ ++ A K++ A D +++ REA+I +L +P IVRL Sbjct: 13 ELGKGAFSVVRRCVHKT--TGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRL 70 Query: 402 IGVCQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 Q E+ LV ++ GG L + +V RE ++ + + Q+ + Y VHR Sbjct: 71 HDSIQEESFHYLVFDLVTGGELFEDIVA-REFYSEADASHCIQQILESIAYCHSNGIVHR 129 Query: 461 DLAARNVLLVNR---HYAKISDFGLSKALGADDSYYT-ARSAGKWPLKWYAPECINFRKF 516 +L N+LL ++ K++DFGL+ + ++++ A + G + +PE + + Sbjct: 130 NLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPG-----YLSPEVLKKDPY 184 Query: 517 SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG 555 S D+W+ GV ++ L G P+ + A I+ G Sbjct: 185 SKPVDIWACGVILY-ILLVGYPPFWDEDQHRLYAQIKAG 222 >5F9E-A nrPDB Length = 353 Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 70/233 (30%), Positives = 109/233 (46%), Gaps = 19/233 (8%) Query: 337 LLIADIEL----GCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQIM 390 L I D EL G G+FG V ++ K AIK LK+ D E M E +++ Sbjct: 16 LKIEDFELHKMLGKGSFGKVFLAEFK--KTNQFFAIKALKKDVVLMDDDVECTMVEKRVL 73 Query: 391 H-QLDNPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMG 448 ++P++ + Q E L VME GG L + + + +S ++ +G Sbjct: 74 SLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDL-MYHIQSCHKFDLSRATFYAAEIILG 132 Query: 449 MKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 +++L K V+RDL N+LL + KI+DFG+ K D+ T G P + AP Sbjct: 133 LQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDA-KTNEFCGT-P-DYIAP 189 Query: 509 ECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECP 561 E + +K++ D WS+GV ++E L GQ P+ E+ I RM+ P Sbjct: 190 EILLGQKYNHSVDWWSFGVLLYEML-IGQSPFHGQDEEELFHSI----RMDNP 237 >3H4J-B nrPDB Length = 336 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 63/201 (31%), Positives = 102/201 (50%), Gaps = 13/201 (6%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTE-EMMREAQIMHQLDNPYIVRL 401 LG G+FG V+ + K Q VA+K + +Q +K+D + RE + L +P+I++L Sbjct: 17 LGEGSFGKVKLATHY--KTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPHIIKL 74 Query: 402 IGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 V +++V+E AGG L ++V K+ + Q+ ++Y VHR Sbjct: 75 YDVITTPTDIVMVIEYAGG-ELFDYIVEKKR-MTEDEGRRFFQQIICAIEYCHRHKIVHR 132 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS-R 519 DL N+LL + KI+DFGLS + D + S G P + APE IN + ++ Sbjct: 133 DLKPENLLLDDNLNVKIADFGLSNIMT--DGNFLKTSCGS-P-NYAAPEVINGKLYAGPE 188 Query: 520 SDVWSYGVTMWEALSYGQKPY 540 DVWS G+ ++ L G+ P+ Sbjct: 189 VDVWSCGIVLYVML-VGRLPF 208 >6E2O-A nrPDB Length = 295 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 72/266 (27%), Positives = 118/266 (44%), Gaps = 24/266 (9%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 + LG G +G V G R Q+ +AIK + + + ++ + E + L + IV+ Sbjct: 28 VVLGKGTYGIVYAG--RDLSNQVRIAIKEIPERDSRY-SQPLHEEIALHKHLKHKNIVQY 84 Query: 402 IGVCQAEALM-LVMEMAGGGPLHKFLVGKREEIPVS--NVAELLHQVSMGMKYLEEKNFV 458 +G + + ME GG L L K + + + Q+ G+KYL + V Sbjct: 85 LGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIV 144 Query: 459 HRDLAARNVLLVNRHYA--KISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF--R 514 HRD+ NV L+N + KISDFG SK L + + L++ APE I+ R Sbjct: 145 HRDIKGDNV-LINTYSGVLKISDFGTSKRLAGINPCTETFTG---TLQYMAPEIIDKGPR 200 Query: 515 KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSD 574 + +D+WS G T+ E ++ G+ P+ ++ P+ F + + PE P + A Sbjct: 201 GYGKAADIWSLGCTIIE-MATGKPPFYELGEPQAAMF--KVGMFKVHPEIPESMSAEAKA 257 Query: 575 CWIYKWEDRPDFLTVEQRMRACYYSL 600 + +E PD RAC L Sbjct: 258 FILKCFEPDPD-------KRACANDL 276 >2XNP-A nrPDB Length = 279 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 64/252 (25%), Positives = 116/252 (46%), Gaps = 16/252 (6%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL-- 401 +G G++G Q + R +I V ++ +A+ + ++ E ++ +L +P IVR Sbjct: 14 IGTGSYGRC-QKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYD 72 Query: 402 -IGVCQAEALMLVMEMAGGGPLHKFLVG---KREEIPVSNVAELLHQVSMGMKYLEEKN- 456 I L +VME GG L + +R+ + V ++ Q+++ +K ++ Sbjct: 73 RIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSD 132 Query: 457 ----FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN 512 +HRDL NV L + K+ DFGL++ L D S+ A++ P + +PE +N Sbjct: 133 GGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSF--AKTFVGTPY-YMSPEQMN 189 Query: 513 FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALM 572 ++ +SD+WS G ++E L P+ E+ I +GK P EL ++ Sbjct: 190 RMSYNEKSDIWSLGCLLYE-LCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEII 248 Query: 573 SDCWIYKWEDRP 584 + K RP Sbjct: 249 TRMLNLKDYHRP 260 >3PFQ-A nrPDB Length = 674 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 63/222 (28%), Positives = 108/222 (48%), Gaps = 27/222 (12%) Query: 334 RDNLLIADIE----LGCGNFGSV----RQGVYRMRKKQIDVAIKVLKQGT--EKADTEEM 383 RD + + D LG G+FG V R+G + A+K+LK+ + D E Sbjct: 335 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDEL------YAVKILKKDVVIQDDDVECT 388 Query: 384 MREAQIMHQLDNPYIVRLIGVC--QAEALMLVMEMAGGGPL--HKFLVGKREEIPVSNVA 439 M E +++ P + + C + L VME GG L H VG+ +E + Sbjct: 389 MVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE---PHAV 445 Query: 440 ELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAG 499 ++++G+ +L+ K ++RDL NV+L + + KI+DFG+ K D T ++ Sbjct: 446 FYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG--VTTKTFC 503 Query: 500 KWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYK 541 P + APE I ++ + D W++GV ++E L+ GQ P++ Sbjct: 504 GTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFE 543 >1VZO-A nrPDB Length = 355 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 70/244 (28%), Positives = 116/244 (47%), Gaps = 21/244 (8%) Query: 344 LGCGNFGSVRQGVYRMRKKQID-----VAIKVLKQGT--EKADTEEMMR-EAQIM-HQLD 394 LG G +G V + +RK A+KVLK+ T +KA T E R E Q++ H Sbjct: 62 LGTGAYGKV----FLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQ 117 Query: 395 NPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 +P++V L Q E L L+++ GG L L +RE V + ++ + +++L Sbjct: 118 SPFLVTLHYAFQTETKLHLILDYINGGELFTHL-SQRERFTEHEVQIYVGEIVLALEHLH 176 Query: 454 EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF 513 + ++RD+ N+LL + + ++DFGLSK AD++ G +++ AP+ + Sbjct: 177 KLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCG--TIEYMAPDIVRG 234 Query: 514 --RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYAL 571 D WS GV M+E L+ G P+ A I + + ++ P P E+ AL Sbjct: 235 GDSGHDKAVDWWSLGVLMYELLT-GASPFTVDGEKNSQAEISR-RILKSEPPYPQEMSAL 292 Query: 572 MSDC 575 D Sbjct: 293 AKDL 296 >5LPV-A nrPDB Length = 296 Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 63/247 (25%), Positives = 118/247 (47%), Gaps = 15/247 (6%) Query: 331 FLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIM 390 L+ N D +G G FG V + + K VAIK L + + D E M E + + Sbjct: 12 LLQATNGFHNDSLIGSGGFGDVYKAIL---KDGSAVAIKKLIHVSGQGD-REFMAEMETI 67 Query: 391 HQLDNPYIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVGKRE---EIPVSNVAELLHQVS 446 ++ + +V L+G C+ + +LV E G L L ++ ++ S ++ + Sbjct: 68 GKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSA 127 Query: 447 MGMKYLEEK---NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPL 503 G+ +L + +HRD+ + NVLL A++SDFG+++ + A D++ + + P Sbjct: 128 RGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTP- 186 Query: 504 KWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKK--MKGPEVMAFIEQGKRMECP 561 + PE + S++ DV+SYGV + E L+ G++P ++ +++Q ++ Sbjct: 187 GYVPPEYYQSFRCSTKGDVYSYGVVLLELLT-GKRPTDSPDFGDNNLVGWVKQHAKLRIS 245 Query: 562 PECPPEL 568 PEL Sbjct: 246 DVFDPEL 252 >2I0E-A nrPDB Length = 353 Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 63/223 (28%), Positives = 108/223 (48%), Gaps = 27/223 (12%) Query: 333 KRDNLLIADIE----LGCGNFGSV----RQGVYRMRKKQIDVAIKVLKQGT--EKADTEE 382 RD + + D LG G+FG V R+G + A+K+LK+ + D E Sbjct: 13 NRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDEL------YAVKILKKDVVIQDDDVEC 66 Query: 383 MMREAQIMHQLDNPYIVRLIGVC--QAEALMLVMEMAGGGPL--HKFLVGKREEIPVSNV 438 M E +++ P + + C + L VME GG L H VG+ +E + Sbjct: 67 TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE---PHA 123 Query: 439 AELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSA 498 ++++G+ +L+ K ++RDL NV+L + + KI+DFG+ K D T ++ Sbjct: 124 VFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG--VTTKTF 181 Query: 499 GKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYK 541 P + APE I ++ + D W++GV ++E L+ GQ P++ Sbjct: 182 CGTP-DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFE 222 >2BDW-A nrPDB Length = 362 Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 58/204 (28%), Positives = 104/204 (50%), Gaps = 15/204 (7%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKA-DTEEMMREAQIMHQLDNPYIVRL 401 ELG G F VR+ V++ ++ A K++ A D +++ REA+I +L +P IVRL Sbjct: 36 ELGKGAFSVVRRCVHKT--TGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRL 93 Query: 402 IGVCQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 Q E+ LV ++ GG L + +V RE ++ + + Q+ + Y VHR Sbjct: 94 HDSIQEESFHYLVFDLVTGGELFEDIVA-REFYSEADASHCIQQILESIAYCHSNGIVHR 152 Query: 461 DLAARNVLLVNR---HYAKISDFGLSKALGADDSYYT-ARSAGKWPLKWYAPECINFRKF 516 +L N+LL ++ K++DFGL+ + ++++ A + G + +PE + + Sbjct: 153 NLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPG-----YLSPEVLKKDPY 207 Query: 517 SSRSDVWSYGVTMWEALSYGQKPY 540 S D+W+ GV ++ L G P+ Sbjct: 208 SKPVDIWACGVILY-ILLVGYPPF 230 >2YCR-A nrPDB Length = 323 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 64/220 (29%), Positives = 106/220 (48%), Gaps = 22/220 (10%) Query: 334 RDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQ------GTEKAD-TEEMMRE 386 RD +++ LG G G V+ R K+ VAIK++ + +AD + E Sbjct: 9 RDEYIMSKT-LGSGACGEVKLAFERKTCKK--VAIKIISKRKFAIGSAREADPALNVETE 65 Query: 387 AQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVS 446 +I+ +L++P I+++ AE +V+E+ GG L +VG + + + +Q+ Sbjct: 66 IEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNK-RLKEATCKLYFYQML 124 Query: 447 MGMKYLEEKNFVHRDLAARNVLLVNRH---YAKISDFGLSKALGADDSYYTARSAGKWPL 503 + ++YL E +HRDL NVLL ++ KI+DFG SK LG R+ P Sbjct: 125 LAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS---LMRTLCGTP- 180 Query: 504 KWYAPEC---INFRKFSSRSDVWSYGVTMWEALSYGQKPY 540 + APE + ++ D WS GV ++ LS G P+ Sbjct: 181 TYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPF 219 >4KIK-B nrPDB Length = 677 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 63/213 (29%), Positives = 98/213 (46%), Gaps = 27/213 (12%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVR--- 400 LG G FG+V + + +QI AIK +Q + E E QIM +L +P +V Sbjct: 27 LGTGGFGNVIRWHNQETGEQI--AIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARD 84 Query: 401 ----LIGVCQAEALMLVMEMAGGGPLHKFL------VGKREEIPVSNVAELLHQVSMGMK 450 + + + +L ME GG L K+L G RE + LL ++ ++ Sbjct: 85 VPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLRE----GAILTLLSDIASALR 140 Query: 451 YLEEKNFVHRDLAARNVLLV---NRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYA 507 YL E +HRDL N++L R KI D G +K L D G L++ A Sbjct: 141 YLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKEL--DQGSLCTSFVG--TLQYLA 196 Query: 508 PECINFRKFSSRSDVWSYGVTMWEALSYGQKPY 540 PE + +K++ D WS+G +E ++ G +P+ Sbjct: 197 PELLEQQKYTVTVDYWSFGTLAFECIT-GFRPF 228 >3ALO-A nrPDB Length = 327 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 63/209 (30%), Positives = 101/209 (48%), Gaps = 15/209 (7%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 E+G G +GSV + V++ QI ++ EK + +M +M D PYIV+ Sbjct: 29 EIGRGAYGSVNKMVHK-PSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFY 87 Query: 403 GVCQAEA-LMLVMEMAGGG--PLHKFLVGKREE-IPVSNVAELLHQVSMGMKYLEEK-NF 457 G E + ME+ +K++ ++ IP + ++ + +L+E Sbjct: 88 GALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKI 147 Query: 458 VHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN----F 513 +HRD+ N+LL K+ DFG+S L DS R AG P + APE I+ Sbjct: 148 IHRDIKPSNILLDRSGNIKLCDFGISGQLV--DSIAKTRDAGCRP--YMAPERIDPSASR 203 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPYKK 542 + + RSDVWS G+T++E L+ G+ PY K Sbjct: 204 QGYDVRSDVWSLGITLYE-LATGRFPYPK 231 >4BTF-A nrPDB Length = 469 Score = 73.6 bits (179), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 58/263 (22%), Positives = 129/263 (49%), Gaps = 18/263 (6%) Query: 356 VYRMRKKQIDVAIKVLKQGTEKADTEEMMR-----EAQIMHQLDNPYIVRLIGVCQAEAL 410 +YR + V IKV +A++ ++R E + M + D+P I+R+ G+C + + Sbjct: 211 IYRGEYHRSPVTIKVF--NNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTV 268 Query: 411 M-----LVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAAR 465 +VME G L + L + +++ +S + L+ + + G+ L +HR++++ Sbjct: 269 KPPEFSIVMEYCELGTLRELL-DREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSS 327 Query: 466 NVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APECIN--FRKFSSRSDV 522 + L+ + K++ F LSK + + A + Y +PE + F + ++++ Sbjct: 328 SFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEI 387 Query: 523 WSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRME-CPPECPPELYALMSDCWIYKWE 581 +S+G+ +WE ++ G+ P++ ++ + + K+ E +CP L ++++C ++ Sbjct: 388 YSFGIVLWE-IATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPS 446 Query: 582 DRPDFLTVEQRMRACYYSLASKV 604 RP + +R+ A S KV Sbjct: 447 QRPSVDGILERLSAVEESTDKKV 469 >5LPZ-A nrPDB Length = 332 Score = 73.6 bits (179), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 63/247 (25%), Positives = 118/247 (47%), Gaps = 15/247 (6%) Query: 331 FLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIM 390 L+ N D +G G FG V + + K VAIK L + + D E M E + + Sbjct: 12 LLQATNGFHNDSLIGSGGFGDVYKAIL---KDGSAVAIKKLIHVSGQGD-REFMAEMETI 67 Query: 391 HQLDNPYIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVGKRE---EIPVSNVAELLHQVS 446 ++ + +V L+G C+ + +LV E G L L ++ ++ S ++ + Sbjct: 68 GKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSA 127 Query: 447 MGMKYLEEK---NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPL 503 G+ +L + +HRD+ + NVLL A++SDFG+++ + A D++ + + P Sbjct: 128 RGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTP- 186 Query: 504 KWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKK--MKGPEVMAFIEQGKRMECP 561 + PE + S++ DV+SYGV + E L+ G++P ++ +++Q ++ Sbjct: 187 GYVPPEYYQSFRCSTKGDVYSYGVVLLELLT-GKRPTDSPDFGDNNLVGWVKQHAKLRIS 245 Query: 562 PECPPEL 568 PEL Sbjct: 246 DVFDPEL 252 >5TOS-A nrPDB Length = 395 Score = 72.8 bits (177), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 75/286 (26%), Positives = 129/286 (45%), Gaps = 38/286 (13%) Query: 341 DIELGCGNFGSVRQGVYRMRK-------KQIDVAIKVLKQGTEKADTEEMMREAQIMHQL 393 D +G G FG V +G + +A+K L Q + E + E + QL Sbjct: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH-REWLTEINYLGQL 128 Query: 394 DNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKR---EEIPVSNVAELLHQVSMGM 449 +P +V+LIG C + E +LV E G L L + + +P + + G+ Sbjct: 129 SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGL 188 Query: 450 KYLEEK--NFVHRDLAARNVLLVNRHYAKISDFGLSK-ALGADDSYYTARSAGKWPLKWY 506 +L ++RD+ A N+LL + AK+SDFGL++ D SY + R G + + Sbjct: 189 AFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY--GYA 246 Query: 507 APECINFRKFSSRSDVWSYGVTMWEALSYGQ-----------------KPYKKMKGPEVM 549 APE ++ ++RSDV+S+GV + E LS + +PY K +V+ Sbjct: 247 APEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSK-RKVL 305 Query: 550 AFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRA 595 ++ + PE + ++ C ++ + RP T++Q +RA Sbjct: 306 LIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRP---TMDQVVRA 348 >3LM0-A nrPDB Length = 327 Score = 72.8 bits (177), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 56/205 (27%), Positives = 104/205 (50%), Gaps = 13/205 (6%) Query: 338 LIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTE-EMMREAQIMHQLDN- 395 ++ ELG G F VRQ + + ++ A K LK+ D E++ E ++ + Sbjct: 31 ILTSKELGRGKFAVVRQCISKSTGQE--YAAKFLKKRRRGQDCRAEILHEIAVLELAKSC 88 Query: 396 PYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSN-VAELLHQVSMGMKYLE 453 P ++ L V + + ++L++E A GG + + + E+ N V L+ Q+ G+ YL Sbjct: 89 PRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLH 148 Query: 454 EKNFVHRDLAARNVLLVNRH---YAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510 + N VH DL +N+LL + + KI DFG+S+ +G R P ++ APE Sbjct: 149 QNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIG---HACELREIMGTP-EYLAPEI 204 Query: 511 INFRKFSSRSDVWSYGVTMWEALSY 535 +N+ ++ +D+W+ G+ + L++ Sbjct: 205 LNYDPITTATDMWNIGIIAYMLLTH 229 >3MN3-A nrPDB Length = 271 Score = 72.8 bits (177), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 58/194 (29%), Positives = 102/194 (52%), Gaps = 12/194 (6%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTE-EMMREAQIMHQLDNPYIVRL 401 LG G+FG V+ + ++ VA+K++ K+ K+D + + RE + L +P+I++L Sbjct: 12 LGEGSFGKVKLAYHTTTGQK--VALKIINKKVLAKSDMQGRIEREISYLRLLRHPHIIKL 69 Query: 402 IGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 V ++ + +++V+E AG L ++V +R+++ Q+ ++Y VHR Sbjct: 70 YDVIKSKDEIIMVIEYAGN-ELFDYIV-QRDKMSEQEARRFFQQIISAVEYCHRHKIVHR 127 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS-R 519 DL N+LL KI+DFGLS + D + S G P + APE I+ + ++ Sbjct: 128 DLKPENLLLDEHLNVKIADFGLSNIM--TDGNFLKTSCGS-P-NYAAPEVISGKLYAGPE 183 Query: 520 SDVWSYGVTMWEAL 533 DVWS GV ++ L Sbjct: 184 VDVWSCGVILYVML 197 >4QTB-A nrPDB Length = 380 Score = 72.4 bits (176), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 52/200 (26%), Positives = 97/200 (48%), Gaps = 16/200 (8%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G G +G V +RK + VAIK + + + +RE QI+ + + ++ + Sbjct: 49 IGEGAYGMVSSAYDHVRKTR--VAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRD 106 Query: 404 VCQAEAL-----MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 + +A L + +++ L+K L K +++ ++ L+Q+ G+KY+ N + Sbjct: 107 ILRASTLEAMRDVYIVQDLMETDLYKLL--KSQQLSNDHICYFLYQILRGLKYIHSANVL 164 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKALGADDS---YYTARSAGKWPLKWYAPEC-INFR 514 HRDL N+L+ KI DFGL++ + + T A +W + APE +N + Sbjct: 165 HRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRW---YRAPEIMLNSK 221 Query: 515 KFSSRSDVWSYGVTMWEALS 534 ++ D+WS G + E LS Sbjct: 222 GYTKSIDIWSVGCILAEMLS 241 >3I6U-A nrPDB Length = 419 Score = 72.4 bits (176), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 69/247 (27%), Positives = 115/247 (46%), Gaps = 36/247 (14%) Query: 311 DTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKV 370 D SVY P+ L+D+ + K LG G G V+ R K+ VAI++ Sbjct: 125 DQSVY------PKALRDEYIMSKT---------LGSGACGEVKLAFERKTCKK--VAIRI 167 Query: 371 LKQ------GTEKAD-TEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLH 423 + + +AD + E +I+ +L++P I+++ AE +V+E+ GG L Sbjct: 168 ISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELF 227 Query: 424 KFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRH---YAKISDF 480 +VG + + + +Q+ + ++YL E +HRDL NVLL ++ KI+DF Sbjct: 228 DKVVGNK-RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDF 286 Query: 481 GLSKALGADDSYYTARSAGKWPLKWYAPEC---INFRKFSSRSDVWSYGVTMWEALSYGQ 537 G SK LG R+ P + APE + ++ D WS GV ++ LS G Sbjct: 287 GHSKILGETS---LMRTLCGTP-TYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GY 341 Query: 538 KPYKKMK 544 P+ + + Sbjct: 342 PPFSEHR 348 >3NIZ-A nrPDB Length = 311 Score = 72.4 bits (176), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 56/209 (26%), Positives = 97/209 (46%), Gaps = 12/209 (5%) Query: 334 RDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEE------MMREA 387 R+NL + V +G Y + K D +++ + D E+ +RE Sbjct: 11 RENLYFQGLMEKYQKLEKVGEGTYGVVYKAKDSQGRIVALKRIRLDAEDEGIPSTAIREI 70 Query: 388 QIMHQLDNPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVS 446 ++ +L +P IV LI V +E L LV E L K L + + S + L+Q+ Sbjct: 71 SLLKELHHPNIVSLIDVIHSERCLTLVFEFMEKD-LKKVLDENKTGLQDSQIKIYLYQLL 129 Query: 447 MGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY 506 G+ + + +HRDL +N+L+ + K++DFGL++A G YT W + Sbjct: 130 RGVAHCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLW---YR 186 Query: 507 APECI-NFRKFSSRSDVWSYGVTMWEALS 534 AP+ + +K+S+ D+WS G E ++ Sbjct: 187 APDVLMGSKKYSTSVDIWSIGCIFAEMIT 215 >4CQG-A nrPDB Length = 331 Score = 72.0 bits (175), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 53/216 (24%), Positives = 98/216 (45%), Gaps = 11/216 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G G F V+ + + + VAIK++ + +D + E + L + +I +L Sbjct: 17 IGTGGFAKVKLACHVLTGEM--VAIKIMDKNALGSDLPRVKTEIDALKSLRHQHICQLYH 74 Query: 404 VCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 V + + + +V+E GG L +++ ++ + + Q+ + Y+ + + HRDL Sbjct: 75 VLETKNKIFMVLEYCPGGELFDYIIS-QDRLSEEETRVVFRQILSAVAYVHSQGYAHRDL 133 Query: 463 AARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKF-SSRSD 521 N+L H K+ DFGL + Y+ G L + APE I + + S +D Sbjct: 134 KPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCG--SLAYAAPELIQGKSYLGSEAD 191 Query: 522 VWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKR 557 VWS G+ ++ L G P+ VMA ++ R Sbjct: 192 VWSMGILLY-VLMCGFLPF---DDDNVMALYKKIMR 223 >3A8W-A nrPDB Length = 345 Score = 72.0 bits (175), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 55/201 (27%), Positives = 101/201 (50%), Gaps = 11/201 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG--TEKADTEEMMREAQIMHQLDN-PYIVR 400 +G G++ V + R++K A+KV+K+ + D + + E + Q N P++V Sbjct: 17 IGRGSYAKVL--LVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVG 74 Query: 401 LIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 L Q E+ L V+E GG L F + ++ ++P + ++S+ + YL E+ ++ Sbjct: 75 LHSCFQTESRLFFVIEYVNGGDL-MFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIY 133 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 519 RDL NVLL + + K++D+G+ K G T+ G + APE + + Sbjct: 134 RDLKLDNVLLDSEGHIKLTDYGMCKE-GLRPGDTTSTFCGT--PNYIAPEILRGEDYGFS 190 Query: 520 SDVWSYGVTMWEALSYGQKPY 540 D W+ GV M+E ++ G+ P+ Sbjct: 191 VDWWALGVLMFEMMA-GRSPF 210 >4YZB-A nrPDB Length = 491 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 63/218 (28%), Positives = 111/218 (50%), Gaps = 13/218 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LG G+FG V ++ ++ V + +Q +K D E +++E +++ +LD+P I++L Sbjct: 38 LGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHPNIMKLYE 97 Query: 404 VCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 + + LV E+ GG L ++ R+ + A ++ QV G+ Y+ + VHRDL Sbjct: 98 FFEDKGYFYLVTEVYTGGELFDEIIS-RKRFSEVDAARIIRQVLSGITYMHKNKIVHRDL 156 Query: 463 AARNVLLVNRH---YAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APECINFRKFSS 518 N+LL N+ +I DFGLS + T + K +Y APE ++ + Sbjct: 157 KPENLLLENKRKDANIRIIDFGLSTHFES-----TKKMKDKIGTAYYIAPEVLH-GTYDE 210 Query: 519 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK 556 + DVWS GV ++ LS G P+ +++ +E+GK Sbjct: 211 KCDVWSTGVILYILLS-GCPPFNGANEFDILKKVEKGK 247 >1U5R-A nrPDB Length = 348 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 68/238 (28%), Positives = 111/238 (46%), Gaps = 23/238 (9%) Query: 329 KLFLKRD-NLLIADI-ELGCGNFGSVRQGVYRMRKKQIDVAIKVL----KQGTEKADTEE 382 +LF K D L +D+ E+G G+FG+V +R ++ VAIK + KQ EK ++ Sbjct: 45 ELFFKDDPEKLFSDLREIGHGSFGAV-YFARDVRNSEV-VAIKKMSYSGKQSNEK--WQD 100 Query: 383 MMREAQIMHQLDNPYIVRLIGV-CQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAEL 441 +++E + + +L +P ++ G + LVME G V K+ V +A + Sbjct: 101 IIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVE-IAAV 159 Query: 442 LHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKW 501 H G+ YL N +HRD+ A N+LL K+ DFG + + +S+ Sbjct: 160 THGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGTPY---- 215 Query: 502 PLKWYAPECI---NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK 556 W APE I + ++ + DVWS G+T E L+ + P M + I Q + Sbjct: 216 ---WMAPEVILAMDEGQYDGKVDVWSLGITCIE-LAERKPPLFNMNAMSALYHIAQNE 269 >3UTO-A nrPDB Length = 573 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 73/289 (25%), Positives = 120/289 (41%), Gaps = 23/289 (7%) Query: 259 ASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGY-TPEPARITSPDKPRPMPMDTSVYE- 316 A N G + P P P + +R+ GY E +I D V++ Sbjct: 84 AENKHGQSKPCEPTAPVLIPGDERK----RRRGYDVDEQGKIVRGKGTVSSNYDNYVFDI 139 Query: 317 --SPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG 374 Y P E+K + D+ I + ELG G FG V + R A K + Sbjct: 140 WKQYYPQPVEIKHDHVL---DHYDIHE-ELGTGAFGVVHRVTERATGNNF--AAKFVMTP 193 Query: 375 TEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEI 433 E +D E + +E Q M L +P +V L + + ++++ E GG L + + + ++ Sbjct: 194 HE-SDKETVRKEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKM 252 Query: 434 PVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNR--HYAKISDFGLSKALGADDS 491 E + QV G+ ++ E N+VH DL N++ + + K+ DFGL+ L S Sbjct: 253 SEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQS 312 Query: 492 YYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY 540 ++ APE + +D+WS GV + LS G P+ Sbjct: 313 VKVTTGTAEFA----APEVAEGKPVGYYTDMWSVGVLSYILLS-GLSPF 356 >3TAC-A nrPDB Length = 361 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 61/223 (27%), Positives = 101/223 (45%), Gaps = 22/223 (9%) Query: 335 DNLLIADI-----ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEK--ADTEEMMREA 387 D++L D+ +G G F VR+ + R +Q V I + + T TE++ REA Sbjct: 20 DDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREA 79 Query: 388 QIMHQLDNPYIVRLIGVCQAEALM-LVMEMAGGGPLHKFLVGKREEIPVSNVAELLH--- 443 I H L +P+IV L+ ++ ++ +V E G L +V + + V + A H Sbjct: 80 SICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMR 139 Query: 444 QVSMGMKYLEEKNFVHRDLAARNVLLVNRHYA---KISDFGLSKALGADDSYYTARSAGK 500 Q+ ++Y + N +HRD+ VLL ++ + K+ FG++ LG R Sbjct: 140 QILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTP 199 Query: 501 WPLKWYAPECINFRKFSSRSDVWSYGVTMWEALS-----YGQK 538 + APE + + DVW GV ++ LS YG K Sbjct: 200 ---HFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTK 239 >3TXO-A nrPDB Length = 353 Score = 70.9 bits (172), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 59/202 (29%), Positives = 96/202 (47%), Gaps = 11/202 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQIMHQLDN-PYIVR 400 LG G+FG V + R+++ A+KVLK+ + D E M E +I+ N P++ + Sbjct: 31 LGKGSFGKVM--LARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQ 88 Query: 401 LIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 L Q + L VME GG L F + K + ++ + +L +K ++ Sbjct: 89 LFCCFQTPDRLFFVMEFVNGGDL-MFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIY 147 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 519 RDL NVLL + + K++DFG+ K G + TA G + APE + + Sbjct: 148 RDLKLDNVLLDHEGHCKLADFGMCKE-GICNGVTTATFCGT--PDYIAPEILQEMLYGPA 204 Query: 520 SDVWSYGVTMWEALSYGQKPYK 541 D W+ GV ++E L G P++ Sbjct: 205 VDWWAMGVLLYEMLC-GHAPFE 225 >2GCD-A nrPDB Length = 309 Score = 70.9 bits (172), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 68/238 (28%), Positives = 111/238 (46%), Gaps = 23/238 (9%) Query: 329 KLFLKRD-NLLIADI-ELGCGNFGSVRQGVYRMRKKQIDVAIKVL----KQGTEKADTEE 382 +LF K D L +D+ E+G G+FG+V +R ++ VAIK + KQ EK ++ Sbjct: 6 ELFFKDDPEKLFSDLREIGHGSFGAVYFA-RDVRNSEV-VAIKKMSYSGKQSNEK--WQD 61 Query: 383 MMREAQIMHQLDNPYIVRLIGV-CQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAEL 441 +++E + + +L +P ++ G + LVME G V K+ V +A + Sbjct: 62 IIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVE-IAAV 120 Query: 442 LHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKW 501 H G+ YL N +HRD+ A N+LL K+ DFG + + +S+ Sbjct: 121 THGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGTPY---- 176 Query: 502 PLKWYAPECI---NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK 556 W APE I + ++ + DVWS G+T E L+ + P M + I Q + Sbjct: 177 ---WMAPEVILAMDEGQYDGKVDVWSLGITCIE-LAERKPPLFNMNAMSALYHIAQNE 230 >1KOA-A nrPDB Length = 491 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 60/230 (26%), Positives = 103/230 (44%), Gaps = 15/230 (6%) Query: 314 VYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQ 373 +++ Y P E+K + D+ I + ELG G FG V + R A K + Sbjct: 33 IWKQYYPQPVEIKHDHVL---DHYDIHE-ELGTGAFGVVHRVTERATGNNF--AAKFVMT 86 Query: 374 GTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREE 432 E +D E + +E Q M L +P +V L + + ++++ E GG L + + + + Sbjct: 87 PHE-SDKETVRKEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNK 145 Query: 433 IPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNR--HYAKISDFGLSKALGADD 490 + E + QV G+ ++ E N+VH DL N++ + + K+ DFGL+ L Sbjct: 146 MSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQ 205 Query: 491 SYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY 540 S ++ APE + +D+WS GV + LS G P+ Sbjct: 206 SVKVTTGTAEFA----APEVAEGKPVGYYTDMWSVGVLSYILLS-GLSPF 250 >2V7O-A nrPDB Length = 336 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 54/202 (26%), Positives = 99/202 (49%), Gaps = 10/202 (4%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ELG G F VR+ V + ++ I K+ + + D +++ REA+I L +P IVRL Sbjct: 38 ELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSAR-DHQKLEREARICRLLKHPNIVRLH 96 Query: 403 GVCQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 E LV ++ GG L + +V RE ++ + +HQ+ + ++ + + VHRD Sbjct: 97 DSISEEGFHYLVFDLVTGGELFEDIVA-REYYSEADASHCIHQILESVNHIHQHDIVHRD 155 Query: 462 LAARNVLLVNR---HYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 L N+LL ++ K++DFGL+ + + + + + +PE + + Sbjct: 156 LKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTP---GYLSPEVLRKDPYGK 212 Query: 519 RSDVWSYGVTMWEALSYGQKPY 540 D+W+ GV ++ L G P+ Sbjct: 213 PVDIWACGVILY-ILLVGYPPF 233 >4JLC-A nrPDB Length = 657 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 66/240 (27%), Positives = 113/240 (47%), Gaps = 29/240 (12%) Query: 338 LIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPY 397 L++DI LG G +V +G R +K A+KV + + MRE +++ +L++ Sbjct: 11 LLSDI-LGQGATANVFRG--RHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNHKN 67 Query: 398 IVRLIGVCQAEAL---MLVMEMAGGGPLHKFLVGKREE------IPVSNVAELLHQVSMG 448 IV+L + + +L+ME G L+ L EE +P S +L V G Sbjct: 68 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVL----EEPSNAYGLPESEFLIVLRDVVGG 123 Query: 449 MKYLEEKNFVHRDLAARNVLLV----NRHYAKISDFGLSKALGADDSYYTARSAGKWPLK 504 M +L E VHRD+ N++ V + K++DFG ++ L D+ + + ++ Sbjct: 124 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHP 183 Query: 505 WYAPECI----NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP----EVMAFIEQGK 556 + + +K+ + D+WS GVT + A + G P++ +GP EVM I GK Sbjct: 184 DMYERAVLRKDHQKKYGATVDLWSVGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGK 242 >5JZN-A nrPDB Length = 280 Score = 70.1 bits (170), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 58/204 (28%), Positives = 95/204 (46%), Gaps = 17/204 (8%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G GNF V++ V R ++ A+K++K+ + + E I+ ++ +P IV LI Sbjct: 27 IGDGNFAVVKECVERSTARE--YALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIE 84 Query: 404 VCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 L LVME+ GG L + + + + +L+ ++ +KYL N VHRD+ Sbjct: 85 EMDVPTELYLVMELVKGGDLFDAITSTNKYTE-RDASGMLYNLASAIKYLHSLNIVHRDI 143 Query: 463 AARNVLLVNRHY-----AKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFS 517 N LLV H K+ DFGL+ + D YT + APE I + Sbjct: 144 KPEN-LLVYEHQDGSKSLKLGDFGLATIV--DGPLYTVCGTP----TYVAPEIIAETGYG 196 Query: 518 SRSDVWSYGVTMWEALSYGQKPYK 541 + D+W+ GV + L G P++ Sbjct: 197 LKVDIWAAGVITYILLC-GFPPFR 219 >6CCF-A nrPDB Length = 290 Score = 70.1 bits (170), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 52/168 (30%), Positives = 89/168 (52%), Gaps = 16/168 (9%) Query: 381 EEMMREAQIMHQLDNPYIVRLIGVCQAEA---LMLVMEMAGGGPLHKFLVGKREEIPVSN 437 E + +E I+ +LD+ +V+LI V A L LV ++ GP+ + K P S Sbjct: 73 ERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDK----PFSE 128 Query: 438 VAELLH--QVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTA 495 L+ V +G++YL + VHRD+ N+LL + + KI+DFG+S +D+ ++ Sbjct: 129 EQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSS 188 Query: 496 RSAGKWPLKWYAPECI--NFRKFSSRS-DVWSYGVTMWEALSYGQKPY 540 + + APE I + + FS ++ DVW+ GVT++ YG+ P+ Sbjct: 189 TAGTP---AFMAPEAISDSGQSFSGKALDVWATGVTLY-CFVYGKCPF 232 >4M66-A nrPDB Length = 325 Score = 70.1 bits (170), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 75/285 (26%), Positives = 120/285 (42%), Gaps = 33/285 (11%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G G FG V + +R DVA+K++ +++++ E + M L N ++ L+G Sbjct: 28 VGKGGFGVVFRAHHRTWNH--DVAVKIV-------NSKKISWEVKAMVNLRNENVLLLLG 78 Query: 404 VCQ------AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN- 456 V + LV G L L + P + LL +V +GM YL + Sbjct: 79 VTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPR-PWPLLCRLLQEVVLGMCYLHSLDP 137 Query: 457 -FVHRDLAARNVLLVNRHYAKISDFGLSK---ALGADDSYYTARSAGKWPLKWYAPECIN 512 +HRDL N+LL +AK++DFGLS + + L + PE + Sbjct: 138 PLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDPELL- 196 Query: 513 FR---KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKR---MECPPECP- 565 F+ K S SDV+S+G+ +W L+ + ++ R E PP P Sbjct: 197 FKVNLKASKASDVYSFGILVWAVLAGREAELVDKTSLIRETVCDRQSRPPLTELPPGSPE 256 Query: 566 ----PELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEG 606 +L LM CW + E+RP F E + Y + KV+ Sbjct: 257 TPGLEKLKELMIHCWGSQSENRPSFQDCEPKTNEVYNLVKDKVDA 301 >2QKW-B nrPDB Length = 321 Score = 70.1 bits (170), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 58/198 (29%), Positives = 99/198 (50%), Gaps = 17/198 (8%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKAD--TEEMMREAQIMHQLDNPYIVRL 401 +G G FG V +GV R D A LK+ T ++ EE E + + +P++V L Sbjct: 47 IGHGVFGKVYKGVLR------DGAKVALKRRTPESSQGIEEFETEIETLSFCRHPHLVSL 100 Query: 402 IGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVA-----ELLHQVSMGMKYLEEK 455 IG C + ++L+ + G L + L G ++P +++ E+ + G+ YL + Sbjct: 101 IGFCDERNEMILIYKYMENGNLKRHLYGS--DLPTMSMSWEQRLEICIGAARGLHYLHTR 158 Query: 456 NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK 515 +HRD+ + N+LL KI+DFG+SK G + + K L + PE + Sbjct: 159 AIIHRDVKSINILLDENFVPKITDFGISKK-GTELDQTHLSTVVKGTLGYIDPEYFIKGR 217 Query: 516 FSSRSDVWSYGVTMWEAL 533 + +SDV+S+GV ++E L Sbjct: 218 LTEKSDVYSFGVVLFEVL 235 >6NT9-A nrPDB Length = 742 Score = 70.1 bits (170), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 66/240 (27%), Positives = 113/240 (47%), Gaps = 29/240 (12%) Query: 338 LIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPY 397 L++DI LG G +V +G R +K AIKV + + MRE +++ +L++ Sbjct: 10 LLSDI-LGQGATANVFRG--RHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKN 66 Query: 398 IVRLIGVCQAEAL---MLVMEMAGGGPLHKFLVGKREE------IPVSNVAELLHQVSMG 448 IV+L + + +L+ME G L+ L EE +P S +L V G Sbjct: 67 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVL----EEPSNAYGLPESEFLIVLRDVVGG 122 Query: 449 MKYLEEKNFVHRDLAARNVLLV----NRHYAKISDFGLSKALGADDSYYTARSAGKWPLK 504 M +L E VHR++ N++ V + K++DFG ++ L D+ + + ++ Sbjct: 123 MNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHP 182 Query: 505 WYAPECI----NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP----EVMAFIEQGK 556 + + +K+ + D+WS GVT + A + G P++ +GP EVM I GK Sbjct: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGK 241 >5FG8-A nrPDB Length = 285 Score = 70.1 bits (170), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 58/210 (27%), Positives = 101/210 (48%), Gaps = 11/210 (5%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 DN I + ELG G F V++ V + + I K+ T + D +++ REA+I +L Sbjct: 14 DNYDIKE-ELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTAR-DFQKLEREARICRKLH 71 Query: 395 NPYIVRLIGVCQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 +P IVRL Q E LV ++ GG L + +V RE ++ + + Q+ + + Sbjct: 72 HPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVA-REFYSEADASHCIQQILESVNHCH 130 Query: 454 EKNFVHRDLAARNVLLVNR---HYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510 + VHRDL N+LL ++ K++DFGL+ + D + + + +PE Sbjct: 131 QNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTP---GYLSPEV 187 Query: 511 INFRKFSSRSDVWSYGVTMWEALSYGQKPY 540 + + D+W+ GV ++ L G P+ Sbjct: 188 LKKEPYGKSVDIWACGVILY-ILLVGYPPF 216 >4EUT-A nrPDB Length = 396 Score = 70.1 bits (170), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 66/240 (27%), Positives = 113/240 (47%), Gaps = 29/240 (12%) Query: 338 LIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPY 397 L++DI LG G +V +G R +K AIKV + + MRE +++ +L++ Sbjct: 12 LLSDI-LGQGATANVFRG--RHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKN 68 Query: 398 IVRLIGVCQAEAL---MLVMEMAGGGPLHKFLVGKREE------IPVSNVAELLHQVSMG 448 IV+L + + +L+ME G L+ L EE +P S +L V G Sbjct: 69 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVL----EEPSNAYGLPESEFLIVLRDVVGG 124 Query: 449 MKYLEEKNFVHRDLAARNVLLV----NRHYAKISDFGLSKALGADDSYYTARSAGKWPLK 504 M +L E VHR++ N++ V + K++DFG ++ L D+ + + ++ Sbjct: 125 MNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHP 184 Query: 505 WYAPECI----NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP----EVMAFIEQGK 556 + + +K+ + D+WS GVT + A + G P++ +GP EVM I GK Sbjct: 185 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGK 243 >1UA2-A nrPDB Length = 346 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 55/198 (27%), Positives = 94/198 (47%), Gaps = 16/198 (8%) Query: 344 LGCGNFGSVRQGVYRMRKKQID--VAIKVLKQG--TEKAD--TEEMMREAQIMHQLDNPY 397 LG G F +V Y+ R K + VAIK +K G +E D +RE +++ +L +P Sbjct: 18 LGEGQFATV----YKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPN 73 Query: 398 IVRLI-GVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 I+ L+ + LV + L + + S++ + G++YL + Sbjct: 74 IIGLLDAFGHKSNISLVFDFMETD-LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHW 132 Query: 457 FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRK 515 +HRDL N+LL K++DFGL+K+ G+ + YT + +W + APE + R Sbjct: 133 ILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFGARM 189 Query: 516 FSSRSDVWSYGVTMWEAL 533 + D+W+ G + E L Sbjct: 190 YGVGVDMWAVGCILAELL 207 >5NGU-A nrPDB Length = 381 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 52/200 (26%), Positives = 95/200 (47%), Gaps = 16/200 (8%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G G +G V + K + VAIK + + + +RE +I+ + + I+ + Sbjct: 50 IGEGAYGMVCSAYDNLNK--VRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGIND 107 Query: 404 VCQAEAL-----MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 + +A + + +++ L+K L K + + ++ L+Q+ G+KY+ N + Sbjct: 108 IIRAPTIEQMKDVYIVQDLMETDLYKLL--KTQHLSNDHICYFLYQILRGLKYIHSANVL 165 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKALGADDS---YYTARSAGKWPLKWYAPEC-INFR 514 HRDL N+LL KI DFGL++ D + T A +W + APE +N + Sbjct: 166 HRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRW---YRAPEIMLNSK 222 Query: 515 KFSSRSDVWSYGVTMWEALS 534 ++ D+WS G + E LS Sbjct: 223 GYTKSIDIWSVGCILAEMLS 242 >4EUU-A nrPDB Length = 319 Score = 69.7 bits (169), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 66/240 (27%), Positives = 113/240 (47%), Gaps = 29/240 (12%) Query: 338 LIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPY 397 L++DI LG G +V +G R +K AIKV + + MRE +++ +L++ Sbjct: 12 LLSDI-LGQGATANVFRG--RHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKN 68 Query: 398 IVRLIGVCQAEAL---MLVMEMAGGGPLHKFLVGKREE------IPVSNVAELLHQVSMG 448 IV+L + + +L+ME G L+ L EE +P S +L V G Sbjct: 69 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVL----EEPSNAYGLPESEFLIVLRDVVGG 124 Query: 449 MKYLEEKNFVHRDLAARNVLLV----NRHYAKISDFGLSKALGADDSYYTARSAGKWPLK 504 M +L E VHR++ N++ V + K++DFG ++ L D+ + + ++ Sbjct: 125 MNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHP 184 Query: 505 WYAPECI----NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP----EVMAFIEQGK 556 + + +K+ + D+WS GVT + A + G P++ +GP EVM I GK Sbjct: 185 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGK 243 >3ORP-A nrPDB Length = 311 Score = 69.7 bits (169), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 51/204 (25%), Positives = 93/204 (45%), Gaps = 11/204 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADT--EEMMREAQIMHQLDNPYIVRL 401 LG G V + R + DVA+KVL+ + + REAQ L++P IV + Sbjct: 20 LGFGGMSEVH--LARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPAIVAV 77 Query: 402 IGVCQAEALM-----LVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 +AE +VME G L + + P + E++ + + + Sbjct: 78 YDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAI-EVIADACQALNFSHQNG 136 Query: 457 FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKF 516 +HRD+ N+++ + K+ DFG+++A+ + T +A ++ +PE Sbjct: 137 IIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQARGDSV 196 Query: 517 SSRSDVWSYGVTMWEALSYGQKPY 540 +RSDV+S G ++E L+ G+ P+ Sbjct: 197 DARSDVYSLGCVLYEVLT-GEPPF 219 >3UDB-A nrPDB Length = 317 Score = 69.7 bits (169), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 74/218 (33%), Positives = 104/218 (47%), Gaps = 24/218 (11%) Query: 338 LIADIELGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADTEEMMREAQIMHQLDN 395 L+ DI G GNFG R MR KQ + VA+K +++G EK D E + RE L + Sbjct: 23 LVKDI--GAGNFGVARL----MRDKQANELVAVKYIERG-EKID-ENVKREIINHRSLRH 74 Query: 396 PYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFL--VGKREEIPVSNVAELLHQVSMGMKYL 452 P IVR V L +VME A GG L + + G+ E Q+ G+ Y Sbjct: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSE---DEARFFFQQLISGVSYA 131 Query: 453 EEKNFVHRDLAARNVLLVNRH--YAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510 HRDL N LL KI+DFG SKA + +SA P + APE Sbjct: 132 HAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKA---SVLHSQPKSAVGTP-AYIAPEV 187 Query: 511 INFRKFSSR-SDVWSYGVTMWEALSYGQKPYKKMKGPE 547 + +++ + +DVWS GVT++ L G P++ + P+ Sbjct: 188 LLKKEYDGKVADVWSCGVTLYVML-VGAYPFEDPEEPK 224 >2Y4I-B nrPDB Length = 319 Score = 69.7 bits (169), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 71/289 (24%), Positives = 122/289 (42%), Gaps = 27/289 (9%) Query: 317 SPYSDPEELKDKKLFLKRDNLLIADIELG----CGNFGSVRQGVYRMRKKQIDVAIKVLK 372 S S P + +FL+ ++ +E+G G FG V G + +VAI+++ Sbjct: 10 SARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHG-----EVAIRLID 64 Query: 373 QGTEKADT-EEMMREAQIMHQLDNPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKR 430 + D + RE Q + +V +G C + L ++ + G L+ + + Sbjct: 65 IERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAK 124 Query: 431 EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGL---SKALG 487 + V+ ++ ++ GM YL K +H+DL ++NV N I+DFGL S L Sbjct: 125 IVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVV-ITDFGLFSISGVLQ 183 Query: 488 ADDSYYTARSAGKWPLKWYAPECI---------NFRKFSSRSDVWSYGVTMWEALSYGQK 538 A R W L APE I + FS SDV++ G T+W L + Sbjct: 184 AGRREDKLRIQNGW-LCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALG-TIWYELHAREW 241 Query: 539 PYKKMKGPEVMAFIEQGKRMECPP-ECPPELYALMSDCWIYKWEDRPDF 586 P+K ++ + G + E+ ++ CW ++ E+RP F Sbjct: 242 PFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTF 290 >4OW8-A nrPDB Length = 283 Score = 69.3 bits (168), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 62/207 (29%), Positives = 98/207 (47%), Gaps = 18/207 (8%) Query: 344 LGCGNFGSVRQGV-YRMRKKQIDVAIKVLKQ--GTEKADTEEMMREAQIMHQLDNPYIVR 400 + G G V + V R+ ++ VA+KVLK ++ E EA+ L++P I Sbjct: 19 IATGGMGQVWEAVDNRLGRR---VAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIAS 75 Query: 401 L--IGVCQ----AEALMLVMEMAGGGPLHKFLVGKRE-EIPVSNVAELLHQVSMGMKYLE 453 + G Q LVME+ G PL+ L KR + + + ++L Q ++ Sbjct: 76 VHDYGESQMNGEGRTAYLVMELVNGEPLNSVL--KRTGRLSLRHALDMLEQTGRALQIAH 133 Query: 454 EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF 513 VHRD+ N+L+ KI+DFG++KA+ A T G ++ APE Sbjct: 134 AAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTA--QYIAPEQALG 191 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPY 540 S SDV+S GV +EA+S G++P+ Sbjct: 192 HDASPASDVYSLGVVGYEAVS-GKRPF 217 >2BRG-A nrPDB Length = 297 Score = 69.3 bits (168), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 57/205 (27%), Positives = 96/205 (46%), Gaps = 15/205 (7%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LG G +G V+ V R+ ++ + V I +K+ + E + +E I L++ +V+ G Sbjct: 15 LGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCP--ENIKKEICINKMLNHENVVKFYG 72 Query: 404 -VCQAEALMLVMEMAGGGPLHKFL---VGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 + L +E GG L + +G +P + HQ+ G+ YL H Sbjct: 73 HRREGNIQYLFLEYCSGGELFDRIEPDIG----MPEPDAQRFFHQLMAGVVYLHGIGITH 128 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKALGADD-SYYTARSAGKWPLKWYAPECINFRKFSS 518 RD+ N+LL R KISDFGL+ ++ + G P + APE + R+F + Sbjct: 129 RDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLP--YVAPELLKRREFHA 186 Query: 519 R-SDVWSYGVTMWEALSYGQKPYKK 542 DVWS G+ + A+ G+ P+ + Sbjct: 187 EPVDVWSCGIVL-TAMLAGELPWDQ 210 >3MIA-A nrPDB Length = 351 Score = 68.9 bits (167), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 54/204 (26%), Positives = 91/204 (44%), Gaps = 21/204 (10%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIK-VLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 ++G G FG V + R RK VA+K VL + ++ +RE +I+ L + +V L Sbjct: 24 KIGQGTFGEVFKA--RHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNL 81 Query: 402 IGVCQAEA---------LMLVMEMAG---GGPLHKFLVGKREEIPVSNVAELLHQVSMGM 449 I +C+ +A + LV + G L LV + +S + ++ + G+ Sbjct: 82 IEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLV----KFTLSEIKRVMQMLLNGL 137 Query: 450 KYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPE 509 Y+ +HRD+ A NVL+ K++DFGL++A + R + WY P Sbjct: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPP 197 Query: 510 --CINFRKFSSRSDVWSYGVTMWE 531 + R + D+W G M E Sbjct: 198 ELLLGERDYGPPIDLWGAGCIMAE 221 >6O8B-A nrPDB Length = 665 Score = 68.9 bits (167), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 66/240 (27%), Positives = 112/240 (46%), Gaps = 29/240 (12%) Query: 338 LIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPY 397 L++DI LG G +V +G R +K AIKV + + MRE +++ +L++ Sbjct: 18 LLSDI-LGQGATANVFRG--RHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKN 74 Query: 398 IVRLIGVCQAEAL---MLVMEMAGGGPLHKFLVGKREE------IPVSNVAELLHQVSMG 448 IV+L + + +L+ME G L+ L EE +P S +L V G Sbjct: 75 IVKLFAIEEETTTRHKVLIMEFCPCGSLYTVL----EEPSNAYGLPESEFLIVLRDVVGG 130 Query: 449 MKYLEEKNFVHRDLAARNVLLV----NRHYAKISDFGLSKALGADDSYYTARSAGKWPLK 504 M +L E VHR++ N++ V + K++DFG ++ L D+ + ++ Sbjct: 131 MNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHP 190 Query: 505 WYAPECI----NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP----EVMAFIEQGK 556 + + +K+ + D+WS GVT + A + G P++ +GP EVM I GK Sbjct: 191 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPFRPFEGPRRNKEVMYKIITGK 249 >6GU6-A nrPDB Length = 302 Score = 68.9 bits (167), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 52/193 (26%), Positives = 94/193 (48%), Gaps = 9/193 (4%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ++G G +G V +G ++ Q+ K+ + E+ +RE ++ +L +P IV L Sbjct: 14 KIGEGTYGVVYKGRHKT-TGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQ 72 Query: 403 GVC-QAEALMLVMEMAGGGPLHKFL--VGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 V Q L L+ E L K+L + + + S V L+Q+ G+ + + +H Sbjct: 73 DVLMQDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLH 131 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC-INFRKFSS 518 RDL +N+L+ ++ K++DFGL++A G YT W + +PE + ++S+ Sbjct: 132 RDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLW---YRSPEVLLGSARYST 188 Query: 519 RSDVWSYGVTMWE 531 D+WS G E Sbjct: 189 PVDIWSIGTIFAE 201 >5DYK-A nrPDB Length = 853 Score = 68.9 bits (167), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 69/278 (24%), Positives = 129/278 (46%), Gaps = 33/278 (11%) Query: 277 LTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPM------------DTSVYESPYSDP-- 322 + ++R+ TL + Y E A + D+PR + D SV+ P Sbjct: 465 IVKNKKRLRTLGKNDYFGERALLY--DEPRTASVISKVNNVECWFVDKSVFLQIIQGPML 522 Query: 323 ----EELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIK-VLKQGTEK 377 E +K + ++ D L I +G G FG+V+ + + +I A+K V K+ Sbjct: 523 AHLEERIKMQDTKVEMDELETERI-IGRGTFGTVK--LVHHKPTKIRYALKCVSKRSIIN 579 Query: 378 ADTEEMMR-EAQIMHQLDNPYIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVGKREEIPV 435 + + ++ E +I + D+P+I+RL+ + ++ + E+ GG L+ + K + Sbjct: 580 LNQQNNIKLEREITAENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYD-AIRKLGLLSK 638 Query: 436 SNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTA 495 S L + + ++YL E+N V+RDL N+LL + Y K+ DFG +K + A Sbjct: 639 SQAQFYLGSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQG-----RA 693 Query: 496 RSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEAL 533 + P + APE I + + D+W+ G+ ++E + Sbjct: 694 YTLVGTP-HYMAPEVILGKGYGCTVDIWALGICLYEFI 730 >4M7I-A nrPDB Length = 299 Score = 68.9 bits (167), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 55/214 (25%), Positives = 97/214 (45%), Gaps = 26/214 (12%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LG G FG V + + + + AIK ++ + E++MRE + + +L++P IVR Sbjct: 13 LGRGGFGVVFEA--KNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFN 70 Query: 404 VCQAEA-------------LMLVMEMAGGGPLHKFLVGK--REEIPVSNVAELLHQVSMG 448 + L + M++ L ++ G+ EE S + Q++ Sbjct: 71 AWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEA 130 Query: 449 MKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYT--------ARSAGK 500 +++L K +HRDL N+ K+ DFGL A+ D+ T AR G+ Sbjct: 131 VEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQ 190 Query: 501 WPLKWY-APECINFRKFSSRSDVWSYGVTMWEAL 533 K Y +PE I+ +S + D++S G+ ++E L Sbjct: 191 VGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELL 224 >4X3F-A nrPDB Length = 337 Score = 68.6 bits (166), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 62/207 (29%), Positives = 98/207 (47%), Gaps = 18/207 (8%) Query: 344 LGCGNFGSVRQGV-YRMRKKQIDVAIKVLKQ--GTEKADTEEMMREAQIMHQLDNPYIVR 400 + G G V + V R+ ++ VA+KVLK ++ E EA+ L++P I Sbjct: 20 IATGGMGQVWEAVDNRLGRR---VAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIAS 76 Query: 401 L--IGVCQ----AEALMLVMEMAGGGPLHKFLVGKRE-EIPVSNVAELLHQVSMGMKYLE 453 + G Q LVME+ G PL+ L KR + + + ++L Q ++ Sbjct: 77 VHDYGESQMNGEGRTAYLVMELVNGEPLNSVL--KRTGRLSLRHALDMLEQTGRALQIAH 134 Query: 454 EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF 513 VHRD+ N+L+ KI+DFG++KA+ A T G ++ APE Sbjct: 135 AAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTA--QYIAPEQALG 192 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPY 540 S SDV+S GV +EA+S G++P+ Sbjct: 193 HDASPASDVYSLGVVGYEAVS-GKRPF 218 >4D28-A nrPDB Length = 446 Score = 68.6 bits (166), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 66/233 (28%), Positives = 111/233 (47%), Gaps = 12/233 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQIMHQLDNPYIVRL 401 +G G F V+ R +VAIK++ + T + +++ RE IM + +P IVRL Sbjct: 17 IGEGTFAKVKFA--RNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 Query: 402 IGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 V +++ + +V+E GG L +V K + + Q+ + + K HR Sbjct: 75 YEVLASKSKIYIVLEFVTGGELFDRIVHK-GRLKEDESRKYFQQLVDAVAHCHSKGVYHR 133 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFS-SR 519 DL N+LL K+SDFGLS AL + + G P + APE ++ + + S Sbjct: 134 DLKPENLLLDTNGNLKVSDFGLS-ALPQEGVELLNDTCGT-P-NYVAPEVLSGQGYDGSA 190 Query: 520 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALM 572 +D+WS GV ++ L+ G P+ + P + I + +CPP E+ L+ Sbjct: 191 ADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAE-FDCPPWFSAEVKFLI 241 >4AGU-A nrPDB Length = 311 Score = 68.2 bits (165), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 52/195 (26%), Positives = 92/195 (47%), Gaps = 9/195 (4%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEM-MREAQIMHQLDNPYIVRL 401 ++G G++G V + R R VAIK + + +++ +RE +++ QL +P +V L Sbjct: 10 KIGEGSYGVVFKC--RNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNL 67 Query: 402 IGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 + V + + L LV E LH+ +R +P V + Q + + + N +HR Sbjct: 68 LEVFRRKRRLHLVFEYCDHTVLHELDRYQRG-VPEHLVKSITWQTLQAVNFCHKHNCIHR 126 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPE-CINFRKFSSR 519 D+ N+L+ K+ DFG ++ L YY A +W + +PE + ++ Sbjct: 127 DVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRW---YRSPELLVGDTQYGPP 183 Query: 520 SDVWSYGVTMWEALS 534 DVW+ G E LS Sbjct: 184 VDVWAIGCVFAELLS 198 >3KN6-A nrPDB Length = 325 Score = 68.2 bits (165), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 60/236 (25%), Positives = 113/236 (47%), Gaps = 21/236 (8%) Query: 331 FLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIM 390 F + +L + D LG G+F R+ V++ K A+K++ + E A+T++ + ++ Sbjct: 6 FYQHYDLDLKDKPLGEGSFSICRKCVHK--KSNQAFAVKIISKRME-ANTQKEITALKLC 62 Query: 391 HQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGM 449 +P IV+L V + LVME+ GG L + + K++ + + ++ ++ + Sbjct: 63 E--GHPNIVKLHEVFHDQLHTFLVMELLNGGELFE-RIKKKKHFSETEASYIMRKLVSAV 119 Query: 450 KYLEEKNFVHRDLAARNVLLVNRH---YAKISDFGLSKALGADDSYYTARSAGKWPLKWY 506 ++ + VHRDL N+L + + KI DFG ++ D+ + L + Sbjct: 120 SHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPC---FTLHYA 176 Query: 507 APECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKK-------MKGPEVMAFIEQG 555 APE +N + D+WS GV ++ LS GQ P++ E+M I++G Sbjct: 177 APELLNQNGYDESCDLWSLGVILYTMLS-GQVPFQSHDRSLTCTSAVEIMKKIKKG 231 >3TKU-A nrPDB Length = 433 Score = 68.2 bits (165), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 59/221 (26%), Positives = 107/221 (48%), Gaps = 14/221 (6%) Query: 328 KKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLK--QGTEKADTEEMMR 385 K++ L R++ I + +G G FG V V +M+ + A+K+L + ++A+T Sbjct: 83 KEMQLHREDFEIIKV-IGRGAFGEV--AVVKMKNTERIYAMKILNKWEMLKRAETACFRE 139 Query: 386 EAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQ 444 E ++ D +I L Q E L LVM+ GG L L +++P + + Sbjct: 140 ERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGE 199 Query: 445 VSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLK 504 + + + + + ++VHRD+ NVLL + +++DFG + D + ++ + G P Sbjct: 200 MVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGT-P-D 257 Query: 505 WYAPECIN-----FRKFSSRSDVWSYGVTMWEALSYGQKPY 540 + +PE + K+ D WS GV M+E L YG+ P+ Sbjct: 258 YISPEILQAMEDGMGKYGPECDWWSLGVCMYEML-YGETPF 297 >4AU8-A nrPDB Length = 296 Score = 68.2 bits (165), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 53/199 (26%), Positives = 95/199 (47%), Gaps = 11/199 (5%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QGTEKADTEEMMREAQIMHQLDNPYIVRL 401 ++G G +G+V + + R+ VA+K ++ ++ +RE ++ +L + IVRL Sbjct: 13 KIGEGTYGTVFKA--KNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 70 Query: 402 IGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 V ++ L LV E L K+ ++ V L Q+ G+ + +N +HR Sbjct: 71 HDVLHSDKKLTLVFEFCDQD-LKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 129 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF--RKFSS 518 DL +N+L+ K++DFGL++A G Y+A WY P + F + +S+ Sbjct: 130 DLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVT----LWYRPPDVLFGAKLYST 185 Query: 519 RSDVWSYGVTMWEALSYGQ 537 D+WS G E + G+ Sbjct: 186 SIDMWSAGCIFAELANAGR 204 >4FG9-A nrPDB Length = 320 Score = 68.2 bits (165), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 59/191 (30%), Positives = 90/191 (47%), Gaps = 11/191 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LG G F V + ++ Q VAIK + + + M E ++H++ +P IV L Sbjct: 26 LGTGAFSEVI--LAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIVALDD 83 Query: 404 VCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 + ++ L L+M++ GG L +V K + + L+ QV +KYL + VHRDL Sbjct: 84 IYESGGHLYLIMQLVSGGELFDRIVEKGFYTE-RDASRLIFQVLDAVKYLHDLGIVHRDL 142 Query: 463 AARNVL---LVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 519 N+L L ISDFGLSK +D +A P + APE + + +S Sbjct: 143 KPENLLYYSLDEDSKIMISDFGLSK---MEDPGSVLSTACGTP-GYVAPEVLAQKPYSKA 198 Query: 520 SDVWSYGVTMW 530 D WS GV + Sbjct: 199 VDCWSIGVIAY 209 >6B2Q-A nrPDB Length = 317 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 62/207 (29%), Positives = 98/207 (47%), Gaps = 18/207 (8%) Query: 344 LGCGNFGSVRQGV-YRMRKKQIDVAIKVLKQ--GTEKADTEEMMREAQIMHQLDNPYIVR 400 + G G V + V R+ ++ VA+KVLK ++ E EA+ L++P I Sbjct: 40 IATGGMGQVWEAVDNRLGRR---VAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIAS 96 Query: 401 L--IGVCQ----AEALMLVMEMAGGGPLHKFLVGKRE-EIPVSNVAELLHQVSMGMKYLE 453 + G Q LVME+ G PL+ L KR + + + ++L Q ++ Sbjct: 97 VHDYGESQMNGEGRTAYLVMELVNGEPLNSVL--KRTGRLSLRHALDMLEQTGRALQIAH 154 Query: 454 EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF 513 VHRD+ N+L+ KI+DFG++KA+ A T G ++ APE Sbjct: 155 AAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTA--QYIAPEQALG 212 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPY 540 S SDV+S GV +EA+S G++P+ Sbjct: 213 HDASPASDVYSLGVVGYEAVS-GKRPF 238 >3ORZ-A nrPDB Length = 316 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 56/213 (26%), Positives = 102/213 (47%), Gaps = 14/213 (6%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG--TEKADTEEMMREAQIMHQLDNPYIVRL 401 LG G+F +V + R + AIK+L++ ++ + RE +M +LD+P+ V+L Sbjct: 45 LGEGSFSTVV--LARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKL 102 Query: 402 IGVCQA-EALMLVMEMAGGGPLHKFL--VGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 Q E L + A G L K++ +G +E ++ ++YL K + Sbjct: 103 YFCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTA---EIVSALEYLHGKGII 159 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 HRDL N+LL + +I+DFG +K L + A S ++ +PE + + Sbjct: 160 HRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSF-VGTAQYVSPELLTEKSACK 218 Query: 519 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAF 551 SD+W+ G +++ ++ G P++ G E + F Sbjct: 219 SSDLWALGCIIYQLVA-GLPPFR--AGNEYLIF 248 >3ZDU-A nrPDB Length = 325 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 53/197 (26%), Positives = 91/197 (46%), Gaps = 20/197 (10%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ++G G++G+V + ++ QI VAIK+ + E++ + MRE + + Q + +V LI Sbjct: 10 KVGEGSYGTVMKCKHK-NTGQI-VAIKIFYERPEQSVNKIAMREIKFLKQFHHENLVNLI 67 Query: 403 GVC-QAEALMLVMEMAGGGPLHKF------LVGKREEIPVSNVAELLHQVSMGMKYLEEK 455 V Q + + LV E L + L KR + + L Q+ + YL Sbjct: 68 EVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKR-------LRKYLFQILRAIDYLHSN 120 Query: 456 NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFR 514 N +HRD+ N+L+ K+ DFG ++ L A Y A +W + APE + Sbjct: 121 NIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRW---YRAPELVLKDT 177 Query: 515 KFSSRSDVWSYGVTMWE 531 + D+W+ G + E Sbjct: 178 SYGKPVDIWALGCMIIE 194 >2WQN-A nrPDB Length = 310 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 69/270 (25%), Positives = 122/270 (45%), Gaps = 26/270 (9%) Query: 343 ELGCGNFGSVRQ------GVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNP 396 ++G G F V + GV KK V I L +AD ++E ++ QL++P Sbjct: 39 KIGRGQFSEVYRAACLLDGVPVALKK---VQIFDLMDAKARADC---IKEIDLLKQLNHP 92 Query: 397 YIVRLIG-VCQAEALMLVMEMAGGGPLHKFLVGKREE---IPVSNVAELLHQVSMGMKYL 452 +++ + L +V+E+A G L + + +++ IP V + Q+ ++++ Sbjct: 93 NVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHM 152 Query: 453 EEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN 512 + +HRD+ NV + K+ D GL + + + A S P + +PE I+ Sbjct: 153 HSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTT--AAHSLVGTPY-YMSPERIH 209 Query: 513 FRKFSSRSDVWSYGVTMWEALSYGQKPY--KKMKGPEVMAFIEQGKRMECPPE-CPPELY 569 ++ +SD+WS G ++E ++ Q P+ KM + IEQ P + EL Sbjct: 210 ENGYNFKSDIWSLGCLLYE-MAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELR 268 Query: 570 ALMSDCWIYKWEDRPDFL---TVEQRMRAC 596 L++ C E RPD V +RM AC Sbjct: 269 QLVNMCINPDPEKRPDVTYVYDVAKRMHAC 298 >5FET-A nrPDB Length = 847 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 52/193 (26%), Positives = 96/193 (49%), Gaps = 12/193 (6%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIK-VLKQGTEKADTEEMMR-EAQIMHQLDNPYIVRL 401 +G G FG+V+ + + QI A+K V K+ + + ++ E +I + D+P+I+RL Sbjct: 541 IGRGTFGTVK--LVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAENDHPFIIRL 598 Query: 402 IGVCQ-AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 + + + + E+ GG L+ + K + L + + ++YL E+N V+R Sbjct: 599 VRTFKDSNCFYFLTELVTGGELYD-AIRKLGLLSKPQAQFYLGSIILAIEYLHERNIVYR 657 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRS 520 DL N+LL + Y K+ DFG +K + A + P + APE I + + Sbjct: 658 DLKPENILLDKQGYVKLIDFGCAKKIQG-----RAYTLVGTP-HYMAPEVILGKGYGCTV 711 Query: 521 DVWSYGVTMWEAL 533 D+W+ GV ++E + Sbjct: 712 DIWALGVCLYEFI 724 >2JDO-A nrPDB Length = 342 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 60/234 (25%), Positives = 107/234 (45%), Gaps = 13/234 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQIMHQLDNPYIVRL 401 LG G FG V + R + A+K+L++ K + + E++++ +P++ L Sbjct: 18 LGKGTFGKVI--LVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTAL 75 Query: 402 IGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELL-HQVSMGMKYLEEKNFVH 459 Q + L VME A GG L F RE + A ++ ++YL ++ V+ Sbjct: 76 KYAFQTHDRLCFVMEYANGGEL--FFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVY 133 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 519 RD+ N++L + KI+DFGL K +D + T ++ P ++ APE + + Sbjct: 134 RDIKLENLMLDKDGHIKITDFGLCKEGISDGA--TMKTFCGTP-EYLAPEVLEDNDYGRA 190 Query: 520 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMS 573 D W GV M+E + G+ P+ + I + + P PE +L++ Sbjct: 191 VDWWGLGVVMYEMMC-GRLPFYNQDHERLFELILM-EEIRFPRTLSPEAKSLLA 242 >1KOB-A nrPDB Length = 387 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 50/201 (24%), Positives = 92/201 (45%), Gaps = 11/201 (5%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ELG G FG V + V + + V + D + E IM+QL +P ++ L Sbjct: 58 ELGSGAFGVVHRCVEKATGR---VFVAKFINTPYPLDKYTVKNEISIMNQLHHPKLINLH 114 Query: 403 GVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 + + ++L++E GG L + + ++ + V + Q G+K++ E + VH D Sbjct: 115 DAFEDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHEHSIVHLD 174 Query: 462 LAARNVLLVNRHYA--KISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 519 + N++ + + KI DFGL+ L D+ + ++ APE ++ Sbjct: 175 IKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFA----APEIVDREPVGFY 230 Query: 520 SDVWSYGVTMWEALSYGQKPY 540 +D+W+ GV + LS G P+ Sbjct: 231 TDMWAIGVLGYVLLS-GLSPF 250 >4TNB-A nrPDB Length = 590 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 61/209 (29%), Positives = 101/209 (48%), Gaps = 19/209 (9%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEM-MREAQIMHQLDNPYIVRLI 402 LG G FG V R K ++ K+ +K E M + E QI+ ++++ ++V L Sbjct: 192 LGKGGFGEVCACQVRATGKMY-ACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLA 250 Query: 403 GVCQA-EALMLVMEMAGGGPLHKFLV------GKREEIPVSNVAELLHQVSMGMKYLEEK 455 + +AL LV+ + GG L KF + G EE + AE+L G++ L + Sbjct: 251 YAYETKDALCLVLTIMNGGDL-KFHIYNMGNPGFEEERALFYAAEIL----CGLEDLHHE 305 Query: 456 NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK 515 N V+RDL N+LL + + +ISD GL+ + D R + + APE +N ++ Sbjct: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD-LIRGRVG---TVGYMAPEVLNNQR 361 Query: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMK 544 + D W G ++E + GQ P++ K Sbjct: 362 YGLSPDYWGLGCLIYEMIE-GQSPFRGRK 389 >3VN9-A nrPDB Length = 340 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 72/274 (26%), Positives = 130/274 (47%), Gaps = 29/274 (10%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQI-MHQLDNPYIVR 400 +ELG G +G V + + + QI +A+K ++ + + ++ + I M +D P+ V Sbjct: 57 MELGRGAYGVVEK-MRHVPSGQI-MAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVT 114 Query: 401 LIGVCQAEA-LMLVMEMAGGG--PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK-N 456 G E + + ME+ +K ++ K + IP + ++ + +++L K + Sbjct: 115 FYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 174 Query: 457 FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN---- 512 +HRD+ NVL+ K+ DFG+S L DS AG P + APE IN Sbjct: 175 VIHRDVKPSNVLINALGQVKMCDFGISGYLV--DSVAKTIDAGCKP--YMAPERINPELN 230 Query: 513 FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECP-PECPPELYA- 570 + +S +SD+WS G+TM E L+ + PY P F + + +E P P+ P + ++ Sbjct: 231 QKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTP----FQQLKQVVEEPSPQLPADKFSA 285 Query: 571 ----LMSDCWIYKWEDRPDFLTVEQRMRACYYSL 600 S C ++RP T + M+ +++L Sbjct: 286 EFVDFTSQCLKKNSKERP---TYPELMQHPFFTL 316 >5X3F-B nrPDB Length = 393 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 75/304 (24%), Positives = 130/304 (42%), Gaps = 64/304 (21%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEK-ADTEEMMREAQIMHQLDNPYIVRL 401 LG G+FG V + + ++ A+K+L KQ K E + E +I+ ++ P++V+L Sbjct: 92 LGTGSFGRVM--LVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 149 Query: 402 -IGVCQAEALMLVMEMAGGGPLHKFL--VGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 L +VME GG + L +G+ E A Q+ + +YL + + Sbjct: 150 EFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAA---QIVLTFEYLHSLDLI 206 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK-WPL----KWYAPECINF 513 +RDL N+L+ + Y +++DFG +K R G+ W L ++ APE I Sbjct: 207 YRDLKPENLLIDQQGYIQVTDFGFAK-----------RVKGRTWTLCGTPEYLAPEIILS 255 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALM- 572 + ++ D W+ GV ++E ++ G P+ + ++ I GK + P +L L+ Sbjct: 256 KGYNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSGK-VRFPSHFSSDLKDLLR 313 Query: 573 ------------------SDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGP------- 607 +D +KW D++ + QR KVE P Sbjct: 314 NLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQR----------KVEAPFIPKFKG 363 Query: 608 PGST 611 PG T Sbjct: 364 PGDT 367 >3NIE-A nrPDB Length = 429 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 54/224 (24%), Positives = 99/224 (44%), Gaps = 40/224 (17%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G G++G V + K + + KV + + D + ++RE I+++L + YI+RL Sbjct: 36 IGRGSYGYVYLAYDKNANKNVAIK-KVNRMFEDLIDCKRILREITILNRLKSDYIIRLHD 94 Query: 404 VCQAEALM------LVMEMAGGGPLHKFLVGKREEIPV----SNVAELLHQVSMGMKYLE 453 + E L+ +V+E+A + K + P+ +V +L+ + +G K++ Sbjct: 95 LIIPEDLLKFDELYIVLEIADSD------LKKLFKTPIFLTEQHVKTILYNLLLGEKFIH 148 Query: 454 EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARS---------------- 497 E +HRDL N LL KI DFGL++ + +D + Sbjct: 149 ESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPHNKN 208 Query: 498 -----AGKWPLKWY-APECINFRK-FSSRSDVWSYGVTMWEALS 534 +WY APE I ++ +++ D+WS G E L+ Sbjct: 209 LKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLN 252 >5LOH-A nrPDB Length = 341 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 64/205 (31%), Positives = 95/205 (46%), Gaps = 20/205 (9%) Query: 347 GNFGSVRQGVYRMRKKQIDVAIKVLKQG--TEKADTEEMMREAQIMHQLDNPYIVRLIGV 404 G FG V G +K A+KV+K+ K T ++ E + +P+IV L Sbjct: 47 GAFGKVYLG----QKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYS 102 Query: 405 CQ-AEALMLVMEMAGGGPLHKFL--VGK-REEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 Q A + LVME GG + L G EE+ V ++E V++ + YL +HR Sbjct: 103 LQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISE----VALALDYLHRHGIIHR 158 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADD----SYYTARSAGKWPLKWYAPECINFRKF 516 DL N+L+ N + K++DFGLSK D T R+ P + APE + R Sbjct: 159 DLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTP-DYLAPELLLGRAH 217 Query: 517 SSRSDVWSYGVTMWEALSYGQKPYK 541 D W+ GV ++E L+ G P+ Sbjct: 218 GPAVDWWALGVCLFEFLT-GIPPFN 241 >4OTD-A nrPDB Length = 341 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 69/224 (30%), Positives = 108/224 (48%), Gaps = 28/224 (12%) Query: 332 LKRDNLLIADIE----LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG--TEKADTEEMMR 385 L++ L + D + LG G+FG V +R + AIK LK+G + + E +M Sbjct: 4 LRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELF--AIKALKKGDIVARDEVESLMC 61 Query: 386 EAQIMHQLDN---PYIVRLIGVCQA-EALMLVMEMAGGGPL----HKFLVGKREEIPVSN 437 E +I+ + + P++V L G Q E + VME + GG L H + + I S Sbjct: 62 EKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSA 121 Query: 438 VAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSK-ALGADDSYYTAR 496 V +G+++L E V+RDL N+LL Y KI+DFGL K +G D T+ Sbjct: 122 C------VVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDR--TST 173 Query: 497 SAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY 540 G ++ APE + ++ D W GV ++E L G+ P+ Sbjct: 174 FCGT--PEFLAPEVLTDTSYTRAVDWWGLGVLLYEML-VGESPF 214 >4IDT-A nrPDB Length = 356 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 70/231 (30%), Positives = 103/231 (44%), Gaps = 16/231 (6%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 + LG G+FG V +RM KQ V K E EE+M A L +P IV L Sbjct: 80 LRLGRGSFGEV----HRMEDKQTGFQCAVKKVRLEVFRAEELMACAG----LTSPRIVPL 131 Query: 402 IG-VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 G V + + + ME+ GG L + LV ++ +P L Q G++YL + +H Sbjct: 132 YGAVREGPWVNIFMELLEGGSLGQ-LVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHG 190 Query: 461 DLAARNVLL-VNRHYAKISDFGLSKALGADDSYYTARSAGKWP--LKWYAPECINFRKFS 517 D+ A NVLL + +A + DFG + L D + P APE + R Sbjct: 191 DVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCD 250 Query: 518 SRSDVWSYGVTMWEALSYGQKPYKK-MKGPEVMAFIEQGKRM-ECPPECPP 566 ++ DVWS M L+ G P+ + +GP + + + E PP C P Sbjct: 251 AKVDVWSSCCMMLHMLN-GCHPWTQFFRGPLCLKIASEPPPVREIPPSCAP 300 >5EFQ-A nrPDB Length = 347 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 66/241 (27%), Positives = 111/241 (46%), Gaps = 35/241 (14%) Query: 344 LGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADTE-EMMREAQIMHQLDNPYIVR 400 +G G +G V Y+ R K VA+K ++ EK +RE +I+ QL + I+ Sbjct: 19 IGEGTYGQV----YKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIIN 74 Query: 401 LIGVCQAE-----------ALMLVMEMAGG---GPLHKFLVGKREEIPVSNVAELLHQVS 446 + + + A LV E G L LV E +++ + Q+ Sbjct: 75 MKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNE----NHIKSFMRQLM 130 Query: 447 MGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSY-YTARSAGKWPLKW 505 G+ Y +KNF+HRD+ N+LL NR K++DFGL++ +++S YT + W + Sbjct: 131 EGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLW---Y 187 Query: 506 YAPE-CINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPEC 564 PE + +++ DVWS G + E + +KP + + +A +E R+ C C Sbjct: 188 RPPELLLGEERYTPAIDVWSCGCILGEL--FTKKPI--FQANQELAQLELISRI-CGSPC 242 Query: 565 P 565 P Sbjct: 243 P 243 >4AW2-A nrPDB Length = 437 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 58/230 (25%), Positives = 110/230 (47%), Gaps = 14/230 (6%) Query: 319 YSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLK--QGTE 376 ++ P K K++ L R++ I + +G G FG V V +++ A+K+L + + Sbjct: 58 WAKPFTSKVKQMRLHREDFEILKV-IGRGAFGEV--AVVKLKNADKVFAMKILNKWEMLK 114 Query: 377 KADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPV 435 +A+T E ++ D+ +I L Q + L LVM+ GG L L + +P Sbjct: 115 RAETACFREERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPE 174 Query: 436 SNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTA 495 L ++ + + + + ++VHRD+ N+L+ + +++DFG L D + ++ Sbjct: 175 EMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSS 234 Query: 496 RSAGKWPLKWYAPECINFR-----KFSSRSDVWSYGVTMWEALSYGQKPY 540 + G P + +PE + ++ D WS GV M+E L YG+ P+ Sbjct: 235 VAVGT-P-DYISPEILQAMEGGKGRYGPECDWWSLGVCMYEML-YGETPF 281 >5J5T-A nrPDB Length = 370 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 55/196 (28%), Positives = 88/196 (44%), Gaps = 19/196 (9%) Query: 344 LGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 +G G +G V Y+ R AIKV+K D + +E +M +P IV Sbjct: 12 IGSGTYGDV----YKARNVNTGELAAIKVIKL-EPGEDFAVVQQEIIMMKDCKHPNIVAY 66 Query: 402 IG-VCQAEALMLVMEMAGGGPLHKF--LVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 G + + L + ME GGG L + G E+ ++ V+ + G+ YL K + Sbjct: 67 FGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSR---ETLQGLYYLHSKGKM 123 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK--- 515 HRD+ N+LL + + K++DFG+S + A R A W APE + Sbjct: 124 HRDIKGANILLTDNGHVKLADFGVSAQITAT---IAKRKAFIGTPYWMAPEVAAVERKGG 180 Query: 516 FSSRSDVWSYGVTMWE 531 ++ D+W+ G+T E Sbjct: 181 YNQLCDLWAVGITAIE 196 >3MV5-A nrPDB Length = 342 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 65/235 (27%), Positives = 107/235 (45%), Gaps = 14/235 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQIMHQLDNPYIVRL 401 LG G FG V + + + A+K+LK+ K + + E +++ +P++ L Sbjct: 18 LGKGTFGKVI--LVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTAL 75 Query: 402 IGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELL-HQVSMGMKYLE-EKNFV 458 Q + L VME A GG L F RE + + A ++ + YL EKN V Sbjct: 76 KYSFQTHDRLCFVMEYANGGEL--FFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVV 133 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 +RDL N++L + KI+DFGL K D + T ++ P ++ APE + + Sbjct: 134 YRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA--TMKTFCGTP-EYLAPEVLEDNDYGR 190 Query: 519 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMS 573 D W GV M+E + G+ P+ ++ I + + P PE +L+S Sbjct: 191 AVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILM-EEIRFPRTLGPEAKSLLS 243 >6CMJ-A nrPDB Length = 321 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 51/212 (24%), Positives = 101/212 (47%), Gaps = 20/212 (9%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAI----KVLKQG----TEKADTEEMMREAQIMHQLD 394 E+G G++G V+ + + K+++Q + E++ +E I+ +LD Sbjct: 41 EIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEIAILKKLD 100 Query: 395 NPYIVRLIGVC---QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKY 451 +P +V+L+ V + L +V E+ GP+ + V + + + G++Y Sbjct: 101 HPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME--VPTLKPLSEDQARFYFQDLIKGIEY 158 Query: 452 LEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI 511 L + +HRD+ N+L+ + KI+DFG+S D+ + + APE + Sbjct: 159 LHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTP---AFMAPESL 215 Query: 512 NFRK--FSSRS-DVWSYGVTMWEALSYGQKPY 540 + + FS ++ DVW+ GVT++ +GQ P+ Sbjct: 216 SETRKIFSGKALDVWAMGVTLY-CFVFGQCPF 246 >5YV8-A nrPDB Length = 298 Score = 66.2 bits (160), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 44/166 (26%), Positives = 84/166 (50%), Gaps = 12/166 (7%) Query: 381 EEMMREAQIMHQLDNPYIVRLIGVC---QAEALMLVMEMAGGGPLHKFLVGKREEIPVSN 437 E++ +E I+ +LD+P +V+L+ V + L +V E+ GP+ + V + + Sbjct: 81 EQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME--VPTLKPLSEDQ 138 Query: 438 VAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARS 497 + G++YL + +HRD+ N+L+ + KI+DFG+S D+ + Sbjct: 139 ARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTV 198 Query: 498 AGKWPLKWYAPECINFRK--FSSRS-DVWSYGVTMWEALSYGQKPY 540 + APE ++ + FS ++ DVW+ GVT++ +GQ P+ Sbjct: 199 GTP---AFMAPESLSETRKIFSGKALDVWAMGVTLY-CFVFGQCPF 240 >3N9X-A nrPDB Length = 432 Score = 65.9 bits (159), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 58/231 (25%), Positives = 107/231 (46%), Gaps = 34/231 (14%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 DN +I + +G G++G V + +K + + KV + + D + ++RE I+++L Sbjct: 26 DNYIIKHL-IGRGSYGYVYLAYDKNTEKNVAIK-KVNRMFEDLIDCKRILREITILNRLK 83 Query: 395 NPYIVRLIGVC------QAEALMLVMEMAGGG--PLHKFLVGKREEIPVSNVAELLHQVS 446 + YI+RL + + + L +V+E+A L K + EE ++ +L+ + Sbjct: 84 SDYIIRLYDLIIPDDLLKFDELYIVLEIADSDLKKLFKTPIFLTEE----HIKTILYNLL 139 Query: 447 MGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGA--DDSYYTARSAGKWP-- 502 +G ++ E +HRDL N LL K+ DFGL++ + + D + + P Sbjct: 140 LGENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGP 199 Query: 503 --------------LKWY-APECINFRKFSSRS-DVWSYGVTMWEALSYGQ 537 +WY APE I ++ ++S D+WS G E L+ Q Sbjct: 200 HNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQ 250 >3F3Z-A nrPDB Length = 277 Score = 65.9 bits (159), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 67/227 (29%), Positives = 97/227 (42%), Gaps = 36/227 (15%) Query: 344 LGCGNFGSVRQGV---YRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVR 400 +G G++G V+ V R+R+ A K+ K E D + +E +IM LD+P I+R Sbjct: 17 IGRGSWGEVKIAVQKGTRIRR----AAKKIPKYFVE--DVDRFKQEIEIMKSLDHPNIIR 70 Query: 401 LIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 L + + LVME+ GG L + +V KR S+ A ++ V + Y + N H Sbjct: 71 LYETFEDNTDIYLVMELCTGGELFERVVHKR-VFRESDAARIMKDVLSAVAYCHKLNVAH 129 Query: 460 RDLAARNVLLVN---RHYAKISDFGLSKAL--------GADDSYYTARSAGKWPLKWYAP 508 RDL N L + K+ DFGL+ YY + + Y P Sbjct: 130 RDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVLE---GLYGP 186 Query: 509 ECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG 555 EC D WS GV M+ L G P+ EVM I +G Sbjct: 187 EC----------DEWSAGVMMYVLLC-GYPPFSAPTDSEVMLKIREG 222 >3HDN-A nrPDB Length = 373 Score = 65.9 bits (159), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 55/202 (27%), Positives = 102/202 (50%), Gaps = 13/202 (6%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQIM-HQLDNPYIVR 400 +G G+FG V + R + +++ A+KVL++ +K + + +M E ++ + +P++V Sbjct: 46 IGKGSFGKVL--LARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVG 103 Query: 401 L-IGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLH-QVSMGMKYLEEKNFV 458 L A+ L V++ GG L L +RE + A +++ + YL N V Sbjct: 104 LHFSFQTADKLYFVLDYINGGELFYHL--QRERCFLEPRARFYAAEIASALGYLHSLNIV 161 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 +RDL N+LL ++ + ++DFGL K +S T + P ++ APE ++ + + Sbjct: 162 YRDLKPENILLDSQGHIVLTDFGLCKENIEHNS--TTSTFCGTP-EYLAPEVLHKQPYDR 218 Query: 519 RSDVWSYGVTMWEALSYGQKPY 540 D W G ++E L YG P+ Sbjct: 219 TVDWWCLGAVLYEML-YGLPPF 239 >3UIM-A nrPDB Length = 326 Score = 65.5 bits (158), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 64/231 (27%), Positives = 110/231 (47%), Gaps = 36/231 (15%) Query: 328 KKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREA 387 ++L + DN +I LG G FG V +G R+ + VA+K LK+ + + E Sbjct: 23 RELQVASDNFSNKNI-LGRGGFGKVYKG--RLADGTL-VAVKRLKEERTQGGELQFQTEV 78 Query: 388 QIMHQLDNPYIVRLIGVCQA--EALMLVMEMAGGG-------------PLHKFLVGKREE 432 +++ + ++RL G C E L++ MA G PL KR+ Sbjct: 79 EMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLD---WPKRQR 135 Query: 433 IPVSNVAELLHQVSMGMKYLEEK---NFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD 489 I + + + G+ YL + +HRD+ A N+LL A + DFGL+K + Sbjct: 136 IALGS--------ARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYK 187 Query: 490 DSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY 540 D++ T +A + + APE ++ K S ++DV+ YGV + E ++ GQ+ + Sbjct: 188 DTHVT--TAVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELIT-GQRAF 235 >4WB7-A nrPDB Length = 405 Score = 65.5 bits (158), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 62/242 (25%), Positives = 113/242 (46%), Gaps = 28/242 (11%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEK-ADTEEMMREAQIMHQLDNPYIVRL 401 LG G+FG V + + ++ A+K+L KQ K E + E +I+ ++ P++V+L Sbjct: 104 LGTGSFGRVM--LVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKL 161 Query: 402 -IGVCQAEALMLVMEMAGGGPLHKFL--VGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 L +VME GG + L +G+ E A Q+ + +YL + + Sbjct: 162 EFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAA---QIVLTFEYLHSLDLI 218 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK-WPL----KWYAPECINF 513 +RDL N+L+ + Y +++DFG +K R G+ W L ++ APE I Sbjct: 219 YRDLKPENLLIDQQGYIQVTDFGFAK-----------RVKGRTWTLCGTPEYLAPEIILS 267 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMS 573 + ++ D W+ GV ++E ++ G P+ + ++ I GK + P +L L+ Sbjct: 268 KGYNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSGK-VRFPSHFSSDLKDLLR 325 Query: 574 DC 575 + Sbjct: 326 NL 327 >5KCV-A nrPDB Length = 460 Score = 65.5 bits (158), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 65/235 (27%), Positives = 107/235 (45%), Gaps = 14/235 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQIMHQLDNPYIVRL 401 LG G FG V + + + A+K+LK+ K + + E +++ +P++ L Sbjct: 170 LGKGTFGKVI--LVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTAL 227 Query: 402 IGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELL-HQVSMGMKYLE-EKNFV 458 Q + L VME A GG L F RE + + A ++ + YL EKN V Sbjct: 228 KYSFQTHDRLCFVMEYANGGEL--FFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVV 285 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 +RDL N++L + KI+DFGL K D + T ++ P ++ APE + + Sbjct: 286 YRDLKLENLMLDKDGHIKITDFGLCKEGIKDGA--TMKTFCGTP-EYLAPEVLEDNDYGR 342 Query: 519 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMS 573 D W GV M+E + G+ P+ ++ I + + P PE +L+S Sbjct: 343 AVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILM-EEIRFPRTLGPEAKSLLS 395 >5IG1-A nrPDB Length = 344 Score = 65.5 bits (158), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 54/202 (26%), Positives = 96/202 (47%), Gaps = 13/202 (6%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G G F +V + V + + V + LK ++ ++ RE I L + +IV + Sbjct: 25 IGKGAFSTVHRCVNKRTGEVCAVKVIALK-SLRSSEINKIKREIGICSSLQHEHIVSMRR 83 Query: 404 VCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 + E+ LV E GG L +V R+ + + +HQ+ +++ KN +HRDL Sbjct: 84 AFRDESHFYLVFEYVSGGELFDEIV-TRKFYNEKDASACMHQILSALQHCHSKNIIHRDL 142 Query: 463 AARNVLLVNRH---YAKISDFGLSKALGADDSYYT-ARSAGKWPLKWYAPECINFRKFSS 518 N+LL ++ KI+DFGL+ + +Y+ A + G + +PE I + + Sbjct: 143 KPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPG-----YLSPEVIRRVPYDT 197 Query: 519 RSDVWSYGVTMWEALSYGQKPY 540 DVW+ GV ++ L G P+ Sbjct: 198 AVDVWACGVILY-ILLVGYPPF 218 >4B8L-A nrPDB Length = 286 Score = 65.5 bits (158), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 57/200 (28%), Positives = 94/200 (47%), Gaps = 12/200 (6%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTE-EMMREAQIMHQLDNPYIVRL 401 LG G FG+V + R ++ + +A+KVL K EK E ++ RE +I L +P I+R+ Sbjct: 23 LGKGKFGNVY--LAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRM 80 Query: 402 IGVCQ-AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 + + L++E A G L+K L K A + +++ + Y E+ +HR Sbjct: 81 YNYFHDRKRIYLMLEFAPRGELYKEL-QKHGRFDEQRSATFMEELADALHYCHERKVIHR 139 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRS 520 D+ N+L+ + KI+DFG S + R L + PE I + + Sbjct: 140 DIKPENLLMGYKGELKIADFGWSVHAPS-----LRRRTMCGTLDYLPPEMIEGKTHDEKV 194 Query: 521 DVWSYGVTMWEALSYGQKPY 540 D+W GV +E L G P+ Sbjct: 195 DLWCAGVLCYEFL-VGMPPF 213 >4PL5-B nrPDB Length = 435 Score = 65.5 bits (158), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 64/240 (26%), Positives = 104/240 (43%), Gaps = 23/240 (9%) Query: 315 YESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIK-VLKQ 373 + S D E+ + + + + + + D+ LG G G++ VY+ DVA+K +L + Sbjct: 7 FPSLEQDDEDEETRMVIVGKISFCPKDV-LGHGAEGTI---VYKGMFDNRDVAVKRILPE 62 Query: 374 GTEKADTEEMMREAQIMHQLD-NPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREE 432 AD RE Q++ + D +P ++R + + L +++ K Sbjct: 63 CFSFAD-----REVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFA 117 Query: 433 IPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLV-----NRHYAKISDFGLSKALG 487 LLHQ + G+ +L N VHRDL N+LL R A ISDFGL K L Sbjct: 118 HLGLEPITLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLA 177 Query: 488 ADDSYYTARSAGKWPLKWYAPE-----CINFRKFSSRSDVWSYGVTMWEALSYGQKPYKK 542 ++ RS W APE C + ++ D++S G + +S G P+ K Sbjct: 178 VGRHSFSRRSGVPGTEGWIAPEMLSEDCKDNPTYT--VDIFSAGCVFYYVISEGYHPFGK 235 >5N23-A nrPDB Length = 352 Score = 65.5 bits (158), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 76/305 (24%), Positives = 130/305 (42%), Gaps = 65/305 (21%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEK-ADTEEMMREAQIMHQLDNPYIVRL 401 LG G+FG V + + ++ A+K+L KQ K E + E +I ++ P++V+L Sbjct: 50 LGTGSFGRVM--LVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNFPFLVKL 107 Query: 402 -IGVCQAEALMLVMEMAGGGPLHKFL--VGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 L +V+E A GG + L +G+ E A Q+ + +YL + + Sbjct: 108 EFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAA---QIVLTFEYLHSLDLI 164 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK--WPL----KWYAPECIN 512 +RDL N+L+ + Y K++DFG +K R G+ W L ++ APE I Sbjct: 165 YRDLKPENLLIDQQGYIKVADFGFAK-----------RVKGRTPWTLCGTPEYLAPEIIL 213 Query: 513 FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALM 572 + ++ D W+ GV ++E ++ G P+ + ++ I GK + P +L L+ Sbjct: 214 SKGYNKAVDWWALGVLIYE-MAAGYPPFFADQPIQIYEKIVSGK-VRFPSHFSSDLKDLL 271 Query: 573 -------------------SDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGP------ 607 +D +KW D++ + QR KVE P Sbjct: 272 RNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQR----------KVEAPFIPKFK 321 Query: 608 -PGST 611 PG T Sbjct: 322 GPGDT 326 >2VD5-A nrPDB Length = 412 Score = 65.1 bits (157), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 66/276 (23%), Positives = 119/276 (43%), Gaps = 37/276 (13%) Query: 319 YSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--E 376 +++P ++ K++ L+RD+ I + +G G F V V +M++ A+K++ + + Sbjct: 45 WAEPIVVRLKEVRLQRDDFEILKV-IGRGAFSEV--AVVKMKQTGQVYAMKIMNKWDMLK 101 Query: 377 KADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPV 435 + + E ++ D +I +L Q E L LVME GG L L E IP Sbjct: 102 RGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPA 161 Query: 436 SNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTA 495 L ++ M + + +VHRD+ N+LL + +++DFG L AD + + Sbjct: 162 EMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSL 221 Query: 496 RSAGKWPLKWYAPECIN-------FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEV 548 + G + +PE + + D W+ GV +E + YGQ P+ E Sbjct: 222 VAVGT--PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYE-MFYGQTPFYADSTAET 278 Query: 549 ------------MAFIEQG---------KRMECPPE 563 + +++G +R+ CPPE Sbjct: 279 YGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPE 314 >4YHJ-A nrPDB Length = 584 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 97/209 (46%), Gaps = 19/209 (9%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LG G FG V R K K+ ++ + E +I+ ++ + ++V L Sbjct: 193 LGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAY 252 Query: 404 VCQA-EALMLVMEMAGGGPLHKFLV------GKREEIPVSNVAELLHQVSMGMKYLEEKN 456 + +AL LV+ + GG L KF + G E+ V AEL G++ L+ + Sbjct: 253 AYETKDALCLVLTIMNGGDL-KFHIYNLGNPGFDEQRAVFYAAEL----CCGLEDLQRER 307 Query: 457 FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK-WPLKWYAPECINFRK 515 V+RDL N+LL +R + +ISD GL+ + R G+ + + APE +N K Sbjct: 308 IVYRDLKPENILLDDRGHIRISDLGLATEIPE-----GQRVRGRVGTVGYMAPEVVNNEK 362 Query: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMK 544 ++ D W G ++E + G P+KK K Sbjct: 363 YTFSPDWWGLGCLIYEMIQ-GHSPFKKYK 390 >4BBM-A nrPDB Length = 331 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 52/195 (26%), Positives = 84/195 (43%), Gaps = 13/195 (6%) Query: 348 NFGSVRQGVYRMRKK-------QIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVR 400 N G V +G Y M K +I K L+ +K + MRE +++ QL + +V Sbjct: 29 NLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVN 88 Query: 401 LIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 L+ VC+ + LV E L + + V + L Q+ G+ + N +H Sbjct: 89 LLEVCKKKKRWYLVFEFVDHTILDDLELFPNG-LDYQVVQKYLFQIINGIGFCHSHNIIH 147 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPE-CINFRKFSS 518 RD+ N+L+ K+ DFG ++ L A Y A +W + APE + K+ Sbjct: 148 RDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRW---YRAPELLVGDVKYGK 204 Query: 519 RSDVWSYGVTMWEAL 533 DVW+ G + E Sbjct: 205 AVDVWAIGCLVTEMF 219 >3NYO-A nrPDB Length = 576 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 55/218 (25%), Positives = 102/218 (46%), Gaps = 13/218 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LG G FG V R K K+ ++ + E QI+ ++++ ++V L Sbjct: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 Query: 404 VCQA-EALMLVMEMAGGGPL--HKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 + +AL LV+ + GG L H + +G+ P + ++ G++ L + V+R Sbjct: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQ-AGFPEARAVFYAAEICCGLEDLHRERIVYR 310 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRS 520 DL N+LL + + +ISD GL A+ + G + + APE + +++ Sbjct: 311 DLKPENILLDDHGHIRISDLGL--AVHVPEGQTIKGRVGT--VGYMAPEVVKNERYTFSP 366 Query: 521 DVWSYGVTMWEALSYGQKPY----KKMKGPEVMAFIEQ 554 D W+ G ++E ++ GQ P+ KK+K EV +++ Sbjct: 367 DWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKE 403 >1G3N-A nrPDB Length = 326 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 57/224 (25%), Positives = 100/224 (44%), Gaps = 23/224 (10%) Query: 332 LKRDNLLIAD------IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMR 385 +++D L AD E+G G +G V + + +V Q E+ +R Sbjct: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR 60 Query: 386 EAQIMHQLD---NPYIVRLIGVCQAE------ALMLVMEMAGGGPLHKFLVGKREE-IPV 435 E ++ L+ +P +VRL VC L LV E L +L E +P Sbjct: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQD-LTTYLDKVPEPGVPT 119 Query: 436 SNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTA 495 + +++ Q+ G+ +L VHRDL +N+L+ + K++DFGL++ S+ A Sbjct: 120 ETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY----SFQMA 175 Query: 496 RSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKP 539 ++ L + APE + +++ D+WS G E + +KP Sbjct: 176 LTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEM--FRRKP 217 >5WAX-A nrPDB Length = 310 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 66/211 (31%), Positives = 97/211 (45%), Gaps = 18/211 (8%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ++G GNFG R + R R VA+K +++G EK D E + RE L +P I+R Sbjct: 18 DIGSGNFGVAR--LMRNRADGQLVAVKYIERG-EKID-ENVQREIINHRSLRHPNIIRFK 73 Query: 403 GVCQAEA-LMLVMEMAGGGPLHKFL--VGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 V L +VME A GG L + + G+ E Q+ G+ Y H Sbjct: 74 EVILTPTHLAIVMEYASGGELFERICNAGRFSE---DEARFFFQQLISGVSYCHSMQVCH 130 Query: 460 RDLAARNVLLVNRH--YAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFS 517 RDL N LL KI DFG SK+ + +S P + APE + +++ Sbjct: 131 RDLKLENTLLDGSTAPRLKICDFGYSKSSVL---HSQPKSTVGTP-AYIAPEVLLKKEYD 186 Query: 518 SR-SDVWSYGVTMWEALSYGQKPYKKMKGPE 547 + +DVWS GVT++ L G P++ P+ Sbjct: 187 GKVADVWSCGVTLYVML-VGAYPFEDPDEPK 216 >3Q53-A nrPDB Length = 306 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 49/199 (24%), Positives = 89/199 (44%), Gaps = 10/199 (5%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVR-L 401 ++G G G+V + +++ + L+Q +K E ++ E +M + NP IV L Sbjct: 28 KIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKK---ELIINEILVMRENKNPNIVNYL 84 Query: 402 IGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 + L +VME GG L + + +A + + +++L +HRD Sbjct: 85 DSYLVGDELWVVMEYLAGGSLTDVVT--ETCMDEGQIAAVCRECLQALEFLHSNQVIHRD 142 Query: 462 LAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSD 521 + + N+LL K++DFG + + S RS W APE + + + + D Sbjct: 143 IKSDNILLGMDGSVKLTDFGFCAQITPEQS---KRSTMVGTPYWMAPEVVTRKAYGPKVD 199 Query: 522 VWSYGVTMWEALSYGQKPY 540 +WS G+ E + G+ PY Sbjct: 200 IWSLGIMAIEMIE-GEPPY 217 >6FD3-A nrPDB Length = 300 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 48/199 (24%), Positives = 88/199 (44%), Gaps = 10/199 (5%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVR-L 401 ++G G G+V + +++ + L+Q +K E ++ E +M + NP IV L Sbjct: 29 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKK---ELIINEILVMRENKNPNIVNYL 85 Query: 402 IGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 + L +VME GG L V + +A + + + +L +HRD Sbjct: 86 DSYLVGDELWVVMEYLAGGSLTD--VVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRD 143 Query: 462 LAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSD 521 + + N+LL K++DFG + + S + + W APE + + + + D Sbjct: 144 IKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPY---WMAPEVVTRKAYGPKVD 200 Query: 522 VWSYGVTMWEALSYGQKPY 540 +WS G+ E + G+ PY Sbjct: 201 IWSLGIMAIEMVE-GEPPY 218 >5UIU-A nrPDB Length = 323 Score = 64.3 bits (155), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 69/275 (25%), Positives = 124/275 (45%), Gaps = 33/275 (12%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMR----EAQIMHQLDNPYI 398 ++G G FG V +G VA+K L + TEE+ + E ++M + + + Sbjct: 54 KMGEGGFGVVYKGYVN----NTTVAVKKLAAMVD-ITTEELKQQFDQEIKVMAKCQHENL 108 Query: 399 VRLIGVCQ-AEALMLVMEMAGGGPLHKFLVGKREEIPVS--NVAELLHQVSMGMKYLEEK 455 V L+G + L LV G L L P+S ++ + G+ +L E Sbjct: 109 VELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHEN 168 Query: 456 NFVHRDLAARNVLLVNRHYAKISDFGLSKALGA-DDSYYTARSAGKWPLKWYAPECINFR 514 + +HRD+ + N+LL AKISDFGL++A + T+R G + APE + Sbjct: 169 HHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTA--YMAPEALR-G 225 Query: 515 KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMA---------------FIEQGKRME 559 + + +SD++S+GV + E ++ G + + P+++ +I++ K + Sbjct: 226 EITPKSDIYSFGVVLLEIIT-GLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDK-KMND 283 Query: 560 CPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMR 594 +Y++ S C K RPD V+Q ++ Sbjct: 284 ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQ 318 >3FME-A nrPDB Length = 290 Score = 64.3 bits (155), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 71/274 (25%), Positives = 129/274 (47%), Gaps = 29/274 (10%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQI-MHQLDNPYIVR 400 +ELG G +G V + + + QI +A+K ++ + + ++ + I M +D P+ V Sbjct: 13 MELGRGAYGVVEK-MRHVPSGQI-MAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVT 70 Query: 401 LIGVCQAEA-LMLVMEMAGGG--PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK-N 456 G E + + ME+ +K ++ K + IP + ++ + +++L K + Sbjct: 71 FYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLS 130 Query: 457 FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN---- 512 +HRD+ NVL+ K+ DFG+S L D AG P + APE IN Sbjct: 131 VIHRDVKPSNVLINALGQVKMCDFGISGYLV--DDVAKDIDAGCKP--YMAPERINPELN 186 Query: 513 FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECP-PECPPELYA- 570 + +S +SD+WS G+TM E L+ + PY P F + + +E P P+ P + ++ Sbjct: 187 QKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTP----FQQLKQVVEEPSPQLPADKFSA 241 Query: 571 ----LMSDCWIYKWEDRPDFLTVEQRMRACYYSL 600 S C ++RP T + M+ +++L Sbjct: 242 EFVDFTSQCLKKNSKERP---TYPELMQHPFFTL 272 >5G6V-A nrPDB Length = 324 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 53/192 (27%), Positives = 89/192 (46%), Gaps = 10/192 (5%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 +LG G + +V +G ++ VA+K ++ E+ +RE ++ L + IV L Sbjct: 9 KLGEGTYATVYKGKSKLTDNL--VALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLH 66 Query: 403 GVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 + E +L LV E L ++L I + NV L Q+ G+ Y + +HRD Sbjct: 67 DIIHTEKSLTLVFEYLDKD-LKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRD 125 Query: 462 LAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF--RKFSSR 519 L +N+L+ R K++DFGL++A S T + WY P I +S++ Sbjct: 126 LKPQNLLINERGELKLADFGLARA----KSIPTKTYDNEVVTLWYRPPDILLGSTDYSTQ 181 Query: 520 SDVWSYGVTMWE 531 D+W G +E Sbjct: 182 IDMWGVGCIFYE 193 >4AF3-A nrPDB Length = 292 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 62/201 (30%), Positives = 94/201 (46%), Gaps = 12/201 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTE-EMMREAQIMHQLDNPYIVRL 401 LG G FG+V + R +K VA+KVL K EK E ++ RE +I L +P I+RL Sbjct: 31 LGKGKFGNVY--LAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRL 88 Query: 402 IG-VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 + L++E A G L+K L K A ++ +++ + Y K +HR Sbjct: 89 YNYFYDRRRIYLILEYAPRGELYKEL-QKSCTFDEQRTATIMEELADALMYCHGKKVIHR 147 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRS 520 D+ N+LL + KI+DFG S + R L + PE I R + + Sbjct: 148 DIKPENLLLGLKGELKIADFGWSVHAPS-----LRRKTMCGTLDYLPPEMIEGRMHNEKV 202 Query: 521 DVWSYGVTMWEALSYGQKPYK 541 D+W GV +E L G P++ Sbjct: 203 DLWCIGVLCYELL-VGNPPFE 222 >3UC3-A nrPDB Length = 361 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 63/210 (30%), Positives = 97/210 (46%), Gaps = 18/210 (8%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ++G GNFG R ++ K+ VA+K +++G A E + RE L +P IVR Sbjct: 27 DIGSGNFGVARLMRDKLTKEL--VAVKYIERGA--AIDENVQREIINHRSLRHPNIVRFK 82 Query: 403 GVCQAEA-LMLVMEMAGGGPLHKFL--VGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 V L ++ME A GG L++ + G+ E Q+ G+ Y H Sbjct: 83 EVILTPTHLAIIMEYASGGELYERICNAGRFSE---DEARFFFQQLLSGVSYCHSMQICH 139 Query: 460 RDLAARNVLLVNRH--YAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFS 517 RDL N LL KI DFG SK+ + +S P + APE + +++ Sbjct: 140 RDLKLENTLLDGSPAPRLKICDFGYSKSSVL---HSQPKSTVGTP-AYIAPEVLLRQEYD 195 Query: 518 SR-SDVWSYGVTMWEALSYGQKPYKKMKGP 546 + +DVWS GVT++ L G P++ + P Sbjct: 196 GKIADVWSCGVTLYVML-VGAYPFEDPEEP 224 >4IC8-A nrPDB Length = 442 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 50/207 (24%), Positives = 101/207 (48%), Gaps = 20/207 (9%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKA-DTEEMMREAQIMHQLDNPYIVRLI 402 +G G +G V R+ +Q VAIK + + + + +RE +I+ + I+ + Sbjct: 63 IGNGAYGVVSSARRRLTGQQ--VAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIK 120 Query: 403 GVC-------QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK 455 + + +++ +V+++ LH+ ++ + + + +V L+Q+ G+KY+ Sbjct: 121 DILRPTVPYGEFKSVYVVLDLMESD-LHQ-IIHSSQPLTLEHVRYFLYQLLRGLKYMHSA 178 Query: 456 NFVHRDLAARNVLLVNRHYAKISDFGLSKAL---GADDSYY-TARSAGKWPLKWYAPEC- 510 +HRDL N+L+ KI DFG+++ L A+ Y+ T A +W + APE Sbjct: 179 QVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRW---YRAPELM 235 Query: 511 INFRKFSSRSDVWSYGVTMWEALSYGQ 537 ++ +++ D+WS G E L+ Q Sbjct: 236 LSLHEYTQAIDLWSVGCIFGEMLARRQ 262 >4APC-A nrPDB Length = 350 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 35/155 (22%), Positives = 82/155 (52%), Gaps = 5/155 (3%) Query: 379 DTEEMMREAQIMHQLDNPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEI-PVS 436 + EE RE ++ + +P IV+ + +L +VM+ GG L K + ++ + Sbjct: 66 EREESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQED 125 Query: 437 NVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTAR 496 + + Q+ + +K++ ++ +HRD+ ++N+ L ++ DFG+++ L + + AR Sbjct: 126 QILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVL--NSTVELAR 183 Query: 497 SAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWE 531 + P + +PE + ++++SD+W+ G ++E Sbjct: 184 ACIGTPY-YLSPEICENKPYNNKSDIWALGCVLYE 217 >4EQM-A nrPDB Length = 294 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 51/186 (27%), Positives = 88/186 (47%), Gaps = 15/186 (8%) Query: 363 QIDVAIKVL------KQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAE-ALMLVME 415 I VAIK + K+ T K E+ +Q+ HQ IV +I V + + LVME Sbjct: 36 NIKVAIKAIFIPPREKEETLKRFEREVHNSSQLSHQ----NIVSMIDVDEEDDCYYLVME 91 Query: 416 MAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYA 475 G L ++ + + V +Q+ G+K+ + VHRD+ +N+L+ + Sbjct: 92 YIEGPTLSEY-IESHGPLSVDTAINFTNQILDGIKHAHDMRIVHRDIKPQNILIDSNKTL 150 Query: 476 KISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSY 535 KI DFG++KAL T G +++++PE +D++S G+ ++E L Sbjct: 151 KIFDFGIAKALSETSLTQTNHVLG--TVQYFSPEQAKGEATDECTDIYSIGIVLYEML-V 207 Query: 536 GQKPYK 541 G+ P+ Sbjct: 208 GEPPFN 213 >3RP9-A nrPDB Length = 458 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 54/236 (22%), Positives = 109/236 (46%), Gaps = 36/236 (15%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G G++G V + ++ K+ + + K+L+ + D + ++RE I+++L++ ++V+++ Sbjct: 61 IGTGSYGHVCEAYDKLEKRVVAIK-KILRVFEDLIDCKRILREIAILNRLNHDHVVKVLD 119 Query: 404 VC------QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNF 457 + + + L +V+E+A K L + ++ LL+ + +G+KY+ Sbjct: 120 IVIPKDVEKFDELYVVLEIADSD--FKKLFRTPVYLTELHIKTLLYNLLVGVKYVHSAGI 177 Query: 458 VHRDLAARNVLLVNRHYAKISDFGLSKALG--------------ADDSYYTA-------- 495 +HRDL N L+ K+ DFGL++ + DD Sbjct: 178 LHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVTFPHTKNLK 237 Query: 496 -RSAGKWPLKWY-APECINFRK-FSSRSDVWSYGVTMWEALSYGQK--PYKKMKGP 546 + G +WY APE I ++ ++ DVWS G E L+ ++ Y +GP Sbjct: 238 RQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAYHADRGP 293 >4KS7-A nrPDB Length = 292 Score = 63.5 bits (153), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 50/205 (24%), Positives = 92/205 (44%), Gaps = 10/205 (4%) Query: 337 LLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNP 396 LL + +++G G+ G V + +Q+ V + L++ + E + E IM + Sbjct: 24 LLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRR---ELLFNEVVIMRDYQHF 80 Query: 397 YIVRLI-GVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK 455 +V + E L ++ME GG L + R + +A + V + YL + Sbjct: 81 NVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVR--LNEEQIATVCEAVLQALAYLHAQ 138 Query: 456 NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK 515 +HRD+ + ++LL K+SDFG + D + + W APE I+ Sbjct: 139 GVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPY---WMAPEVISRSL 195 Query: 516 FSSRSDVWSYGVTMWEALSYGQKPY 540 +++ D+WS G+ + E + G+ PY Sbjct: 196 YATEVDIWSLGIMVIEMVD-GEPPY 219 >6AMW-A nrPDB Length = 255 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 37/98 (37%), Positives = 52/98 (53%), Gaps = 3/98 (3%) Query: 159 ERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYHYLISQDK 217 E+ WYH ++R AE L SG +G FL+R + G ++SL Y VYHY I+ Sbjct: 142 EKHSWYHGPVSRNAAEYLLSSG--INGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 199 Query: 218 AGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACP 255 GK + ++F+TL +LV + ADGLI L P Sbjct: 200 DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAP 237 Score = 42.0 bits (97), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 32/107 (29%), Positives = 54/107 (50%), Gaps = 7/107 (6%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69 +++G +SR A E+L +G+ +G FL+R+ S G +SL ++ R +H+ I +G Sbjct: 146 WYHGPVSR-NAAEYLLSSGI-NGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKL 203 Query: 70 AIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPC---NRPS--GLEPQ 111 ++ AEL +S DGL L P N+P+ G+ P Sbjct: 204 YVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPN 250 >4ZSG-A nrPDB Length = 347 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 50/207 (24%), Positives = 101/207 (48%), Gaps = 20/207 (9%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKA-DTEEMMREAQIMHQLDNPYIVRLI 402 +G G +G V R+ +Q VAIK + + + + +RE +I+ + I+ + Sbjct: 15 IGNGAYGVVSSARRRLTGQQ--VAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIK 72 Query: 403 GVC-------QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK 455 + + +++ +V+++ LH+ ++ + + + +V L+Q+ G+KY+ Sbjct: 73 DILRPTVPYGEFKSVYVVLDLMESD-LHQ-IIHSSQPLTLEHVRYFLYQLLRGLKYMHSA 130 Query: 456 NFVHRDLAARNVLLVNRHYAKISDFGLSKAL---GADDSYY-TARSAGKWPLKWYAPEC- 510 +HRDL N+L+ KI DFG+++ L A+ Y+ T A +W + APE Sbjct: 131 QVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRW---YRAPELM 187 Query: 511 INFRKFSSRSDVWSYGVTMWEALSYGQ 537 ++ +++ D+WS G E L+ Q Sbjct: 188 LSLHEYTQAIDLWSVGCIFGEMLARRQ 214 >6DTL-A nrPDB Length = 364 Score = 63.2 bits (152), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 47/197 (23%), Positives = 88/197 (44%), Gaps = 14/197 (7%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G G +G V + + + + K+ K D + +RE +++ +D+ IV + Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIK-KIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRD 96 Query: 404 VC------QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNF 457 + + + E+ LH+ ++ + + + L+Q+ G+KY+ N Sbjct: 97 IIPPPLRNAFNDVYIAYELMDTD-LHQ-IIRSNQALSEEHCQYFLYQILRGLKYIHSANV 154 Query: 458 VHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPE-CINFRKF 516 +HRDL N+LL KI DFGL++ D + T +W + APE +N + Sbjct: 155 LHRDLKPSNLLLNANCDLKICDFGLARVTSESD-FMTEYVVTRW---YRAPELLLNSSDY 210 Query: 517 SSRSDVWSYGVTMWEAL 533 ++ DVWS G E + Sbjct: 211 TAAIDVWSVGCIFMELM 227 >6HV0-A nrPDB Length = 416 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 90/209 (43%), Gaps = 18/209 (8%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIK-VLKQGTEKADTEEMMREAQIMHQLD-NPYIVRL 401 LG G G++ VYR DVA+K +L + AD RE Q++ + D +P ++R Sbjct: 16 LGHGAEGTI---VYRGMFDNRDVAVKRILPECFSFAD-----REVQLLRESDEHPNVIRY 67 Query: 402 IGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 + + L +++ K LL Q + G+ +L N VHRD Sbjct: 68 FCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRD 127 Query: 462 LAARNVLLV--NRH---YAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN---F 513 L N+L+ N H A ISDFGL K L ++ RS W APE ++ Sbjct: 128 LKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCK 187 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPYKK 542 + D++S G + +S G P+ K Sbjct: 188 ENPTYTVDIFSAGCVFYYVISEGSHPFGK 216 >2OZA-A nrPDB Length = 356 Score = 62.4 bits (150), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 53/209 (25%), Positives = 98/209 (46%), Gaps = 22/209 (10%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 D+ + LG G G V Q ++ R ++ A+K+L+ D + RE ++ + Sbjct: 17 DDYKVTSQVLGLGINGKVLQ-IFNKRTQE-KFALKMLQ------DCPKARREVELHWRAS 68 Query: 395 N-PYIVRLIGVCQA-----EALMLVMEMAGGGPLHKFLVGKREE-IPVSNVAELLHQVSM 447 P+IVR++ V + + L++VME GG L + + ++ +E++ + Sbjct: 69 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 128 Query: 448 GMKYLEEKNFVHRDLAARNVLLVNRH---YAKISDFGLSKALGADDSYYTARSAGKWPLK 504 ++YL N HRD+ N+L ++ K++DFG +K + +S T + Sbjct: 129 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTP----CYTPY 184 Query: 505 WYAPECINFRKFSSRSDVWSYGVTMWEAL 533 + APE + K+ D+WS GV M+ L Sbjct: 185 YVAPEVLGPEKYDKSCDMWSLGVIMYILL 213 >3ZUT-A nrPDB Length = 362 Score = 62.4 bits (150), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 71/218 (32%), Positives = 101/218 (46%), Gaps = 24/218 (11%) Query: 338 LIADIELGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADTEEMMREAQIMHQLDN 395 L+ DI G GNFG R MR KQ + VA+K +++G EK D E + RE L + Sbjct: 23 LVKDI--GSGNFGVARL----MRDKQSNELVAVKYIERG-EKID-ENVKREIINHRSLRH 74 Query: 396 PYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFL--VGKREEIPVSNVAELLHQVSMGMKYL 452 P IVR V L +VME A GG L + + G+ E Q+ G+ Y Sbjct: 75 PNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSE---DEARFFFQQLISGVSYC 131 Query: 453 EEKNFVHRDLAARNVLLVNRH--YAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510 HRDL N LL KI FG SK+ + +S P + APE Sbjct: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVL---HSQPKSTVGTP-AYIAPEV 187 Query: 511 INFRKFSSR-SDVWSYGVTMWEALSYGQKPYKKMKGPE 547 + +++ + +DVWS GVT++ L G P++ + P+ Sbjct: 188 LLKKEYDGKVADVWSCGVTLYVML-VGAYPFEDPEEPK 224 >2W96-B nrPDB Length = 306 Score = 62.0 bits (149), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 52/201 (25%), Positives = 88/201 (43%), Gaps = 20/201 (9%) Query: 343 ELGCGNFGSVRQGVYRMRKKQID--VAIKVLK-QGTEKADTEEMMREAQIMHQLD---NP 396 E+G G +G+V Y+ R VA+K ++ E+ +RE ++ +L+ +P Sbjct: 11 EIGVGAYGTV----YKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFEHP 66 Query: 397 YIVRLIGVCQAE------ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMK 450 +VRL+ VC + LV E +P + +L+ Q G+ Sbjct: 67 NVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLD 126 Query: 451 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510 +L VHRDL N+L+ + K++DFGL++ SY A L + APE Sbjct: 127 FLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY----SYQMALDPVVVTLWYRAPEV 182 Query: 511 INFRKFSSRSDVWSYGVTMWE 531 + +++ D+WS G E Sbjct: 183 LLQSTYATPVDMWSVGCIFAE 203 >2F57-A nrPDB Length = 317 Score = 62.0 bits (149), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 49/200 (24%), Positives = 88/200 (44%), Gaps = 10/200 (5%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 I++G G+ G V + KQ+ V L++ + E + E IM + +V + Sbjct: 51 IKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRR---ELLFNEVVIMRDYHHDNVVDM 107 Query: 402 IG-VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 + L +VME GG L + R + +A + V + YL + +HR Sbjct: 108 YSSYLVGDELWVVMEFLEGGALTDIVTHTR--MNEEQIATVCLSVLRALSYLHNQGVIHR 165 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRS 520 D+ + ++LL + K+SDFG + + + + W APE I+ + + Sbjct: 166 DIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPY---WMAPEVISRLPYGTEV 222 Query: 521 DVWSYGVTMWEALSYGQKPY 540 D+WS G+ + E + G+ PY Sbjct: 223 DIWSLGIMVIEMID-GEPPY 241 >1NY3-A nrPDB Length = 400 Score = 62.0 bits (149), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 53/209 (25%), Positives = 98/209 (46%), Gaps = 22/209 (10%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 D+ + LG G G V Q ++ R ++ A+K+L+ D + RE ++ + Sbjct: 61 DDYKVTSQVLGLGINGKVLQ-IFNKRTQE-KFALKMLQ------DCPKARREVELHWRAS 112 Query: 395 N-PYIVRLIGVCQA-----EALMLVMEMAGGGPLHKFLVGKREE-IPVSNVAELLHQVSM 447 P+IVR++ V + + L++VME GG L + + ++ +E++ + Sbjct: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 Query: 448 GMKYLEEKNFVHRDLAARNVLLVNRH---YAKISDFGLSKALGADDSYYTARSAGKWPLK 504 ++YL N HRD+ N+L ++ K++DFG +K + +S T + Sbjct: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTP----CYTPY 228 Query: 505 WYAPECINFRKFSSRSDVWSYGVTMWEAL 533 + APE + K+ D+WS GV M+ L Sbjct: 229 YVAPEVLGPEKYDKSCDMWSLGVIMYILL 257 >6BXI-A nrPDB Length = 333 Score = 62.0 bits (149), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 64/266 (24%), Positives = 112/266 (42%), Gaps = 56/266 (21%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQIMHQLDNPYIVRL 401 +G G FG VR + + + A+K+L++ EK + E I+ + D+ ++V++ Sbjct: 14 IGRGAFGEVR--LVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKM 71 Query: 402 IGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 Q + L L+ME GG + L+ K++ + + + + + + + F+HR Sbjct: 72 FYSFQDKLNLYLIMEFLPGGDMMTLLM-KKDTLTEEETQFYIAETVLAIDSIHQLGFIHR 130 Query: 461 DLAARNVLLVNRHYAKISDFGL----------------SKALGADDSYY---TARSAGKW 501 D+ N+LL ++ + K+SDFGL + +L +D ++ + R A W Sbjct: 131 DIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETW 190 Query: 502 PLK-------------WYAPECINFRKFSSRSDVWSYGVTMWEAL--------SYGQKPY 540 + APE ++ D WS GV M+E L Q+ Y Sbjct: 191 KRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETY 250 Query: 541 KK-MKGPEVMAFIEQGKRMECPPECP 565 KK M E + F PPE P Sbjct: 251 KKVMNWKETLTF---------PPEVP 267 >4NIF-A nrPDB Length = 333 Score = 62.0 bits (149), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 61/231 (26%), Positives = 106/231 (45%), Gaps = 39/231 (16%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE--KADTEEMMREAQIMHQLDNPYIVRL 401 +G G++ ++ V++ ++ A+KV+ + + E ++R Q +P I+ L Sbjct: 16 IGVGSYSECKRCVHK--ATNMEYAVKVIDKSKRDPSEEIEILLRYGQ------HPNIITL 67 Query: 402 IGVCQ-AEALMLVME-MAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 V + + LV E M GG L K L +++ + +LH + ++YL + VH Sbjct: 68 KDVYDDGKHVYLVTELMRGGELLDKIL--RQKFFSEREASFVLHTIGKTVEYLHSQGVVH 125 Query: 460 RDLAARNVLLV----NRHYAKISDFGLSKALGADDSY-----YTARSAGKWPLKWYAPEC 510 RDL N+L V N +I DFG +K L A++ YTA + APE Sbjct: 126 RDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTA--------NFVAPEV 177 Query: 511 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP-----EVMAFIEQGK 556 + + + D+WS G+ ++ L+ G P+ GP E++ I GK Sbjct: 178 LKRQGYDEGCDIWSLGILLYTMLA-GYTPFA--NGPSDTPEEILTRIGSGK 225 >4JG6-A nrPDB Length = 355 Score = 62.0 bits (149), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 60/233 (25%), Positives = 111/233 (47%), Gaps = 41/233 (17%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEE---MMREAQIMHQLDNPYIV 399 ++G G++ ++ +++ ++ A+K++ + +++ TEE ++R Q +P I+ Sbjct: 42 DIGVGSYSVCKRCIHK--ATNMEFAVKIIDK-SKRDPTEEIEILLRYGQ------HPNII 92 Query: 400 RLIGVCQAEALMLVME--MAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNF 457 L V + V+ M GG L K L +++ + +L ++ ++YL + Sbjct: 93 TLKDVYDDGKYVYVVTELMKGGELLDKIL--RQKFFSEREASAVLFTITKTVEYLHAQGV 150 Query: 458 VHRDLAARNVLLV----NRHYAKISDFGLSKALGADDSY-----YTARSAGKWPLKWYAP 508 VHRDL N+L V N +I DFG +K L A++ YTA + AP Sbjct: 151 VHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTA--------NFVAP 202 Query: 509 ECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP-----EVMAFIEQGK 556 E + + + + D+WS GV ++ L+ G P+ GP E++A I GK Sbjct: 203 EVLERQGYDAACDIWSLGVLLYTMLT-GYTPFA--NGPDDTPEEILARIGSGK 252 >1V0B-A nrPDB Length = 288 Score = 62.0 bits (149), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 41/152 (26%), Positives = 72/152 (47%), Gaps = 4/152 (2%) Query: 384 MREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLH 443 +RE I+ +L + IV+L V + ++++ L K L + L Sbjct: 48 IREISILKELKHSNIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLL 107 Query: 444 QVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPL 503 Q+ G+ Y ++ +HRDL +N+L+ KI+DFGL++A G YT W Sbjct: 108 QLLNGIAYCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLW-- 165 Query: 504 KWYAPECI-NFRKFSSRSDVWSYGVTMWEALS 534 + AP+ + +K+S+ D+WS G E ++ Sbjct: 166 -YRAPDVLMGSKKYSTTIDIWSVGCIFAEMVN 196 >2W4O-A nrPDB Length = 349 Score = 61.6 bits (148), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 56/200 (28%), Positives = 98/200 (49%), Gaps = 15/200 (7%) Query: 356 VYRMRKK--QIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQA-EALML 412 VYR ++K Q A+KVLK+ +K + + E ++ +L +P I++L + + + L Sbjct: 69 VYRCKQKGTQKPYALKVLKKTVDK---KIVRTEIGVLLRLSHPNIIKLKEIFETPTEISL 125 Query: 413 VMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN- 471 V+E+ GG L +V ++ + A+ + Q+ + YL E VHRDL N+L Sbjct: 126 VLELVTGGELFDRIV-EKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATP 184 Query: 472 --RHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTM 529 KI+DFGLSK + + ++ P + APE + + D+WS G+ Sbjct: 185 APDAPLKIADFGLSKIV---EHQVLMKTVCGTP-GYCAPEILRGCAYGPEVDMWSVGIIT 240 Query: 530 WEALSYGQKPYKKMKGPEVM 549 + L G +P+ +G + M Sbjct: 241 YILLC-GFEPFYDERGDQFM 259 >2VN9-A nrPDB Length = 301 Score = 61.6 bits (148), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 53/202 (26%), Positives = 94/202 (46%), Gaps = 10/202 (4%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ELG G F VR+ + ++ I K+ + + D +++ REA+I L +P IVRL Sbjct: 11 ELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSAR-DHQKLEREARICRLLKHPNIVRLH 69 Query: 403 GVCQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 E LV ++ GG L + +V RE ++ + + Q+ + + VHRD Sbjct: 70 DSISEEGFHYLVFDLVTGGELFEDIVA-REYYSEADASHCIQQILESVNHCHLNGIVHRD 128 Query: 462 LAARNVLLVNRH---YAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 L N+LL ++ K++DFGL+ + D + + + +PE + + Sbjct: 129 LKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTP---GYLSPEVLRKDPYGK 185 Query: 519 RSDVWSYGVTMWEALSYGQKPY 540 D+W+ GV ++ L G P+ Sbjct: 186 PVDMWACGVILY-ILLVGYPPF 206 >2ABL-A nrPDB Length = 163 Score = 61.6 bits (148), Expect = 9e-10, Method: Composition-based stats. Identities = 37/98 (37%), Positives = 52/98 (53%), Gaps = 3/98 (3%) Query: 159 ERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYHYLISQDK 217 E+ WYH ++R AE L SG +G FL+R + G ++SL Y VYHY I+ Sbjct: 68 EKHSWYHGPVSRNAAEYLLSSG--INGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 125 Query: 218 AGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACP 255 GK + ++F+TL +LV + ADGLI L P Sbjct: 126 DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAP 163 Score = 38.5 bits (88), Expect = 0.008, Method: Composition-based stats. Identities = 28/92 (30%), Positives = 47/92 (51%), Gaps = 2/92 (2%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69 +++G +SR A E+L +G+ +G FL+R+ S G +SL ++ R +H+ I +G Sbjct: 72 WYHGPVSR-NAAEYLLSSGI-NGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKL 129 Query: 70 AIAGGKAHCGPAELCEFYSRDPDGLPCNLRKP 101 ++ AEL +S DGL L P Sbjct: 130 YVSSESRFNTLAELVHHHSTVADGLITTLHYP 161 >4CRS-A nrPDB Length = 341 Score = 61.6 bits (148), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 61/201 (30%), Positives = 96/201 (47%), Gaps = 16/201 (7%) Query: 347 GNFGSVRQGVYRMRKKQIDVAIKVLKQG--TEKADTEEMMREAQIMHQLD---NPYIVRL 401 G+FG V Y+ + AIK LK+G + + + +M E +I ++ +P++V L Sbjct: 23 GHFGKVLLAEYKNTNEMF--AIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNL 80 Query: 402 IGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 Q E + VME A GG L + P + V +G++YL E V+R Sbjct: 81 FACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAAC--VVLGLQYLHEHKIVYR 138 Query: 461 DLAARNVLLVNRHYAKISDFGLSK-ALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 519 DL N+LL + KI+DFGL K +G D T+ G ++ APE + ++ Sbjct: 139 DLKLDNLLLDTEGFVKIADFGLCKEGMGYGDR--TSTFCGT--PEFLAPEVLTETSYTRA 194 Query: 520 SDVWSYGVTMWEALSYGQKPY 540 D W GV ++E L G+ P+ Sbjct: 195 VDWWGLGVLIYEML-VGESPF 214 >2I6L-A nrPDB Length = 320 Score = 61.6 bits (148), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 63/261 (24%), Positives = 113/261 (43%), Gaps = 39/261 (14%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LGCG G V V K++ + VL T+ + +RE +I+ +LD+ IV++ Sbjct: 19 LGCGGNGLVFSAVDNDCDKRVAIKKIVL---TDPQSVKHALREIKIIRRLDHDNIVKVFE 75 Query: 404 VCQAEALMLVMEMAGGGPLHK-FLVGKREEIPVSNVAE-----------LLHQVSMGMKY 451 + L ++ L+ ++V + E ++NV E ++Q+ G+KY Sbjct: 76 ILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKY 135 Query: 452 LEEKNFVHRDLAARNVLLVNRHYA-KISDFGLSKALGADDSYYTARSAGKWPLKWY-APE 509 + N +HRDL N+ + KI DFGL++ + S+ S G KWY +P Sbjct: 136 IHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEG-LVTKWYRSPR 194 Query: 510 -CINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPEL 568 ++ ++ D+W+ G E L+ G + A + ++M+ E P + Sbjct: 195 LLLSPNNYTKAIDMWAAGCIFAEMLT----------GKTLFAGAHELEQMQLILESIPVV 244 Query: 569 YALMSDCWIYKWEDRPDFLTV 589 + EDR + L+V Sbjct: 245 HE----------EDRQELLSV 255 >6CQF-A nrPDB Length = 297 Score = 61.6 bits (148), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 53/196 (27%), Positives = 88/196 (44%), Gaps = 19/196 (9%) Query: 344 LGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 LG G +G V ++ R K VA+K++K + D + +E I+ + IV Sbjct: 24 LGGGTYGEV----FKARDKVSGDLVALKMVKMEPDD-DVSTLQKEILILKTCRHANIVAY 78 Query: 402 IG-VCQAEALMLVMEMAGGGPLHKF--LVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 G + L + ME G G L + G E+ +S V +V G+ YL + + Sbjct: 79 HGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCR---EVLQGLAYLHSQKKI 135 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR---K 515 HRD+ N+L+ + +++DFG+S +GA + A + W APE Sbjct: 136 HRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPY---WMAPEVAAVALKGG 192 Query: 516 FSSRSDVWSYGVTMWE 531 ++ D+WS G+T E Sbjct: 193 YNELCDIWSLGITAIE 208 >3GC9-A nrPDB Length = 370 Score = 61.6 bits (148), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 65/243 (26%), Positives = 111/243 (45%), Gaps = 34/243 (13%) Query: 344 LGCGNFGSVRQGV-YRMRKKQIDVAIKVLKQGTEK-ADTEEMMREAQIMHQLDNPYIVRL 401 +G G +GSV R+R+K VA+K L + + RE +++ L + ++ L Sbjct: 36 VGSGAYGSVCSAYDARLRQK---VAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGL 92 Query: 402 IGVCQ--------AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 + V +E ++ M G L+ + K + + +V L++Q+ G+KY+ Sbjct: 93 LDVFTPATSIEDFSEVYLVTTLM--GADLNNIV--KSQALSDEHVQFLVYQLLRGLKYIH 148 Query: 454 EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APEC-I 511 +HRDL NV + +I DFGL++ + + Y A +WY APE + Sbjct: 149 SAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEEMTGYVAT-------RWYRAPEIML 201 Query: 512 NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKR-MECPPECPPELYA 570 N+ ++ D+WS G M E L G+ + +I+Q KR ME PE+ A Sbjct: 202 NWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSD------YIDQLKRIMEVVGTPSPEVLA 254 Query: 571 LMS 573 +S Sbjct: 255 KIS 257 >3T04-A nrPDB Length = 123 Score = 61.2 bits (147), Expect = 1e-09, Method: Composition-based stats. Identities = 38/109 (34%), Positives = 55/109 (50%), Gaps = 3/109 (2%) Query: 159 ERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYHYLISQDK 217 E+ WYH ++R AE L SG +G FL+R + G ++SL Y VYHY I+ Sbjct: 14 EKHSWYHGPVSRNAAEYLLSSG--INGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 71 Query: 218 AGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAA 266 GK + ++F+TL +LV + ADGLI L P + G + Sbjct: 72 DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVS 120 Score = 39.3 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 32/106 (30%), Positives = 54/106 (50%), Gaps = 7/106 (6%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69 +++G +SR A E+L +G+ +G FL+R+ S G +SL ++ R +H+ I +G Sbjct: 18 WYHGPVSR-NAAEYLLSSGI-NGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKL 75 Query: 70 AIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPC---NRPS--GLEP 110 ++ AEL +S DGL L P N+P+ G+ P Sbjct: 76 YVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSP 121 >3DLS-A nrPDB Length = 335 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 58/267 (21%), Positives = 117/267 (43%), Gaps = 35/267 (13%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAI----KVLKQ-GTEKADTEEMMREAQIMHQLDNPYI 398 LG G FG V V + + K++ V KVL+ E ++ E I+ ++++ I Sbjct: 32 LGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANI 91 Query: 399 VRLIGVCQAEALM-LVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNF 457 ++++ + + + LVME G G + + + + + Q+ + YL K+ Sbjct: 92 IKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDI 151 Query: 458 VHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFS 517 +HRD+ N+++ K+ DFG + L +YT +++ APE + + Sbjct: 152 IHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGT----IEYCAPEVLMGNPYR 207 Query: 518 S-RSDVWSYGVTMWEALSYGQKPYKKMK-------------GPEVMAFIEQGKRMECPPE 563 ++WS GVT++ L + + P+ +++ E+M+ + ++ PE Sbjct: 208 GPELEMWSLGVTLY-TLVFEENPFCELEETVEAAIHPPYLVSKELMSLV--SGLLQPVPE 264 Query: 564 CPPELYALMSDCWI--------YKWED 582 L L++D W+ Y WE+ Sbjct: 265 RRTTLEKLVTDPWVTQPVNLADYTWEE 291 >4NST-A nrPDB Length = 351 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 56/210 (26%), Positives = 97/210 (46%), Gaps = 30/210 (14%) Query: 344 LGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADTE-EMMREAQIMHQLDNPYIVR 400 +G G +G V Y+ + K VA+K ++ EK +RE +I+ QL + +V Sbjct: 21 IGEGTYGQV----YKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVN 76 Query: 401 LIGVCQAE-----------ALMLVMEMAGG---GPLHKFLVGKREEIPVSNVAELLHQVS 446 + + + A LV E G L LV E+ ++ + Q+ Sbjct: 77 MKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSED----HIKSFMKQLM 132 Query: 447 MGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSY-YTARSAGKWPLKW 505 G++Y +KNF+HRD+ N+LL N K++DFGL++ +++S YT + W + Sbjct: 133 EGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW---Y 189 Query: 506 YAPE-CINFRKFSSRSDVWSYGVTMWEALS 534 PE + +++ DVWS G + E + Sbjct: 190 RPPELLLGEERYTPAIDVWSCGCILGELFT 219 >2WTK-C nrPDB Length = 305 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 52/213 (24%), Positives = 96/213 (45%), Gaps = 10/213 (4%) Query: 385 REAQIMHQLDNPYIVRLIGVC---QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAEL 441 +E Q++ +L + +++L+ V + + + +VME G + PV Sbjct: 55 KEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGY 114 Query: 442 LHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKAL---GADDSYYTARSA 498 Q+ G++YL + VH+D+ N+LL KIS G+++AL ADD+ T++ + Sbjct: 115 FCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGS 174 Query: 499 GKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM 558 + A F F + D+WS GVT++ ++ G P++ ++ I +G Sbjct: 175 PAFQPPEIANGLDTFSGF--KVDIWSAGVTLYN-ITTGLYPFEGDNIYKLFENIGKGS-Y 230 Query: 559 ECPPECPPELYALMSDCWIYKWEDRPDFLTVEQ 591 P +C P L L+ Y+ R + Q Sbjct: 231 AIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQ 263 >5Z33-A nrPDB Length = 425 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 62/245 (25%), Positives = 103/245 (42%), Gaps = 43/245 (17%) Query: 324 ELKDKKLFLKRDNLLIAD------IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEK 377 +L+ +K+F + I D ELG G +G V V + + + KV ++K Sbjct: 13 DLQGRKIFKVFNQDFIVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIK-KVTNVFSKK 71 Query: 378 ADTEEMMREAQIM------------HQLDNPYIVRLIGVCQAEALM---LVMEMAGGGPL 422 + +RE +++ + +D P E LM L + G PL Sbjct: 72 ILAKRALREIKLLQHFRGHRNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPL 131 Query: 423 HKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGL 482 ++ ++Q+ G+KY+ N +HRDL N+L+ KI DFGL Sbjct: 132 TD-----------AHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGL 180 Query: 483 SKALGAD----DSYYTARSAGKWPLKWYAPEC-INFRKFSSRSDVWSYGVTMWEALSYGQ 537 ++ D Y T A +W + APE ++F+ ++ DVWS G + E L G Sbjct: 181 ARGFSVDPEENAGYMTEYVATRW---YRAPEIMLSFQSYTKAIDVWSVGCILAELL--GG 235 Query: 538 KPYKK 542 +P+ K Sbjct: 236 RPFFK 240 >3PG1-A nrPDB Length = 362 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 58/224 (25%), Positives = 97/224 (43%), Gaps = 32/224 (14%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADT----------EEMMREAQIMHQL 393 + G++G+V GV + I VAIK + T + ++RE ++++ Sbjct: 30 ISSGSYGAVCAGV---DSEGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRLLNHF 86 Query: 394 DNPYIVRLIGVC------QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSM 447 +P I+ L + L LV E+ L + + +R I ++ ++ + + Sbjct: 87 HHPNILGLRDIFVHFEEPAMHKLYLVTELMRTD-LAQVIHDQRIVISPQHIQYFMYHILL 145 Query: 448 GMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY- 506 G+ L E VHRDL N+LL + + I DF L++ AD A +WY Sbjct: 146 GLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTAD-----ANKTHYVTHRWYR 200 Query: 507 APECI-NFRKFSSRSDVWSYGVTMWE-----ALSYGQKPYKKMK 544 APE + F+ F+ D+WS G M E AL G Y ++ Sbjct: 201 APELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLN 244 >3KA0-A nrPDB Length = 320 Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 57/234 (24%), Positives = 107/234 (45%), Gaps = 23/234 (9%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 D+ + LG G G V Q ++ R ++ A+K+L+ D + RE ++ + Sbjct: 15 DDYKVTSQVLGLGINGKVLQ-IFNKRTQE-KFALKMLQ------DCPKARREVELHWRAS 66 Query: 395 N-PYIVRLIGVCQA-----EALMLVMEMAGGGPLHKFLVGKREE-IPVSNVAELLHQVSM 447 P+IVR++ V + + L++VME GG L + + ++ +E++ + Sbjct: 67 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 126 Query: 448 GMKYLEEKNFVHRDLAARNVLLVNRH---YAKISDFGLSKALGADDSYYTARSAGKWPLK 504 ++YL N HRD+ N+L ++ K++DFG +K + +S + + Sbjct: 127 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL----TEPCYTPY 182 Query: 505 WYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM 558 + APE + K+ D+WS GV M+ L G P+ G + ++ RM Sbjct: 183 YVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRM 235 >2Y7J-A nrPDB Length = 365 Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 63/238 (26%), Positives = 107/238 (44%), Gaps = 29/238 (12%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEM-------MREAQIMHQL-DN 395 +G G VR+ V+R + A+K+++ E+ E++ RE I+ Q+ + Sbjct: 102 IGRGVSSVVRRCVHRATGHEF--AVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGH 159 Query: 396 PYIVRLIGVCQAEALM-LVMEMAGGGPLHKFLVGK---REEIPVSNVAELLHQVSMGMKY 451 P+I+ LI ++ + M LV ++ G L +L K E+ S + LL VS + Sbjct: 160 PHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVS----F 215 Query: 452 LEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI 511 L N VHRDL N+LL + ++SDFG S L + R P + APE + Sbjct: 216 LHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKL---RELCGTP-GYLAPEIL 271 Query: 512 NFRK------FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE 563 + D+W+ GV ++ L+ G P+ + ++ I +G+ PE Sbjct: 272 KCSMDETHPGYGKEVDLWACGVILFTLLA-GSPPFWHRRQILMLRMIMEGQYQFSSPE 328 >4MWI-A nrPDB Length = 294 Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 51/233 (21%), Positives = 109/233 (46%), Gaps = 16/233 (6%) Query: 366 VAIKVLKQ---GTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALM-----LVMEMA 417 VAIKV K+ G+ + +E + M + ++P I+R+ G+C E + +VME Sbjct: 50 VAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYC 109 Query: 418 GGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYL--EEKNFVHRDLAARNVLLVNRHYA 475 G L + L+ + +++ + L+ + G+ L E +H + + N L+ + Sbjct: 110 ELGTLRE-LLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQV 168 Query: 476 KISDFGLSKALGADDSYYTARSAGKWPLKWY-APECIN--FRKFSSRSDVWSYGVTMWEA 532 K++ F L K + T + Y +P+ + F ++ +S+++S+G+ +WE Sbjct: 169 KLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWE- 227 Query: 533 LSYGQKPYKKMKGPEVMAFIEQGKRME-CPPECPPELYALMSDCWIYKWEDRP 584 ++ G P++ ++ + ++ E +CP EL ++ +C + RP Sbjct: 228 IATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRP 280 >2VZ6-A nrPDB Length = 313 Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 52/202 (25%), Positives = 96/202 (47%), Gaps = 10/202 (4%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ELG G F VR+ V + ++ I K+ + + D +++ REA+I L +P IVRL Sbjct: 29 ELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSAR-DHQKLEREARICRLLKHPNIVRLH 87 Query: 403 GVCQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 E L+ ++ GG L + +V RE ++ + + Q+ + + + VHRD Sbjct: 88 DSISEEGHHYLIFDLVTGGELFEDIVA-REYYSEADASHCIQQILEAVLHCHQMGVVHRD 146 Query: 462 LAARNVLLVNR---HYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 L N+LL ++ K++DFGL+ + + + + + +PE + + Sbjct: 147 LKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTP---GYLSPEVLRKDPYGK 203 Query: 519 RSDVWSYGVTMWEALSYGQKPY 540 D+W+ GV ++ L G P+ Sbjct: 204 PVDLWACGVILY-ILLVGYPPF 224 >3DB8-A nrPDB Length = 317 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 44/162 (27%), Positives = 75/162 (46%), Gaps = 6/162 (3%) Query: 381 EEMMREAQIMHQLDNPYIVRLIGVCQAEALM-LVMEMAGGGPLHKFLVGKREEIPVSNVA 439 E+M E I LDNP++V G + + + +V+E+ L + L +R+ + Sbjct: 87 EKMSTEIAIHKSLDNPHVVGFHGFFEDDDFVYVVLEICRRRSLLE-LHKRRKAVTEPEAR 145 Query: 440 ELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAG 499 + Q G++YL +HRDL N+ L + KI DFGL+ + D + Sbjct: 146 YFMRQTIQGVQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGE--RKKDLC 203 Query: 500 KWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYK 541 P + APE + + S D+WS G ++ L G+ P++ Sbjct: 204 GTP-NYIAPEVLCKKGHSFEVDIWSLGCILYTLL-VGKPPFE 243 >4CZT-A nrPDB Length = 464 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 61/228 (26%), Positives = 102/228 (44%), Gaps = 20/228 (8%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMM----REAQIMHQLDNPYIV 399 LG G F V+ R + +VAIKV+ + EK +M+ RE M + +P ++ Sbjct: 19 LGEGTFAKVK--FARNVENGDNVAIKVIDK--EKVLKNKMIAQIKREISTMKLIKHPNVI 74 Query: 400 RLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 R+ V ++ + V+E GG L + + + Q+ + Y + Sbjct: 75 RMFEVMASKTKIYFVLEFVTGGELFD-KISSNGRLKEDEARKYFQQLINAVDYCHSRGVY 133 Query: 459 HRDLAARNVLLVNRHYAKISDFGLS---KALGADDSYYTARSAGKWPLKWYAPECINFRK 515 HRDL N+LL K+SDFGLS + + D +T P + APE IN + Sbjct: 134 HRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGT---P-NYVAPEVINNKG 189 Query: 516 F-SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPP 562 + +++D+WS GV ++ L G P++ + I + + CPP Sbjct: 190 YDGAKADLWSCGVILF-VLMAGYLPFEDSNLTSLYKKIFKAE-FTCPP 235 >5U6Y-A nrPDB Length = 461 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 52/202 (25%), Positives = 96/202 (47%), Gaps = 10/202 (4%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ELG G F VR+ V + ++ I K+ + + D +++ REA+I L +P IVRL Sbjct: 7 ELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSAR-DHQKLEREARICRLLKHPNIVRLH 65 Query: 403 GVCQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 E L+ ++ GG L + +V RE ++ + + Q+ + + + VHRD Sbjct: 66 DSISEEGHHYLIFDLVTGGELFEDIVA-REYYSEADASHCIQQILEAVLHCHQMGVVHRD 124 Query: 462 LAARNVLLVNR---HYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 L N+LL ++ K++DFGL+ + + + + + +PE + + Sbjct: 125 LKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTP---GYLSPEVLRKDPYGK 181 Query: 519 RSDVWSYGVTMWEALSYGQKPY 540 D+W+ GV ++ L G P+ Sbjct: 182 PVDLWACGVILY-ILLVGYPPF 202 >2JC6-A nrPDB Length = 334 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 55/191 (28%), Positives = 83/191 (43%), Gaps = 11/191 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LG G F V + K A+K + + K + E ++ ++ + IV L Sbjct: 30 LGTGAFSEVVLAEEKATGKLF--AVKCIPKKALKGKESSIENEIAVLRKIKHENIVALED 87 Query: 404 VCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 + ++ L LVM++ GG L +V K + + L+ QV + YL VHRDL Sbjct: 88 IYESPNHLYLVMQLVSGGELFDRIVEKGFYTE-KDASTLIRQVLDAVYYLHRMGIVHRDL 146 Query: 463 AARNVLLVNRHYAK---ISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 519 N+L ++ ISDFGLSK G D TA + APE + + +S Sbjct: 147 KPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTP----GYVAPEVLAQKPYSKA 202 Query: 520 SDVWSYGVTMW 530 D WS GV + Sbjct: 203 VDCWSIGVIAY 213 >2BUJ-A nrPDB Length = 317 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 55/228 (24%), Positives = 98/228 (42%), Gaps = 20/228 (8%) Query: 376 EKADTEEMMREAQIMHQLDNPYIVRLIGVC------QAEALMLVMEMAGGGPLHKF--LV 427 E+ D EE REA + ++P I+RL+ C + EA +L+ G ++ L Sbjct: 66 EQQDREEAQREADMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLK 125 Query: 428 GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFG-LSKAL 486 K + + LL + G++ + K + HRDL N+LL + + D G +++A Sbjct: 126 DKGNFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQAC 185 Query: 487 GADDSYYTARSAGKW-----PLKWYAPECINFRK---FSSRSDVWSYGVTMWEALSYGQK 538 + A + W + + APE + + R+DVWS G ++ A+ +G+ Sbjct: 186 IHVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLY-AMMFGEG 244 Query: 539 PYKKM--KGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRP 584 PY + KG V ++ + P L+ L++ RP Sbjct: 245 PYDMVFQKGDSVALAVQNQLSIPQSPRHSSALWQLLNSMMTVDPHQRP 292 >4FIE-A nrPDB Length = 423 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 49/209 (23%), Positives = 87/209 (41%), Gaps = 14/209 (6%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 I++G G+ G V R K + V L++ + E + E IM + +V + Sbjct: 157 IKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR---ELLFNEVVIMRDYQHENVVEM 213 Query: 402 IGV-CQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 + L +VME GG L + R + +A + V + L + +HR Sbjct: 214 YNSYLVGDELWVVMEFLEGGALTDIVTHTR--MNEEQIAAVCLAVLQALSVLHAQGVIHR 271 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRS 520 D+ + ++LL + K+SDFG + + + + W APE I+ + Sbjct: 272 DIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY---WMAPELISRLPYGPEV 328 Query: 521 DVWSYGVTMWEALS-----YGQKPYKKMK 544 D+WS G+ + E + + + P K MK Sbjct: 329 DIWSLGIMVIEMVDGEPPYFNEPPLKAMK 357 >3BHH-A nrPDB Length = 295 Score = 59.3 bits (142), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 51/202 (25%), Positives = 93/202 (46%), Gaps = 10/202 (4%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ++G G F VR+ V + I K+ + + D +++ REA+I L + IVRL Sbjct: 11 DIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSAR-DHQKLEREARICRLLKHSNIVRLH 69 Query: 403 GVCQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 E LV ++ GG L + +V RE ++ + + Q+ + + + VHRD Sbjct: 70 DSISEEGFHYLVFDLVTGGELFEDIVA-REYYSEADASHCIQQILEAVLHCHQMGVVHRD 128 Query: 462 LAARNVLLVNR---HYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 L N+LL ++ K++DFGL+ + D + + + +PE + + Sbjct: 129 LKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTP---GYLSPEVLRKEAYGK 185 Query: 519 RSDVWSYGVTMWEALSYGQKPY 540 D+W+ GV ++ L G P+ Sbjct: 186 PVDIWACGVILY-ILLVGYPPF 206 >3SOA-A nrPDB Length = 444 Score = 58.9 bits (141), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 51/202 (25%), Positives = 96/202 (47%), Gaps = 10/202 (4%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ELG G F VR+ V + ++ I K+ + + D +++ REA+I L +P IVRL Sbjct: 18 ELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSAR-DHQKLEREARICRLLKHPNIVRLH 76 Query: 403 GVCQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 E L+ ++ GG L + +V RE ++ + + Q+ + + + VHR+ Sbjct: 77 DSISEEGHHYLIFDLVTGGELFEDIVA-REYYSEADASHCIQQILEAVLHCHQMGVVHRN 135 Query: 462 LAARNVLLVNR---HYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 L N+LL ++ K++DFGL+ + + + + + +PE + + Sbjct: 136 LKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTP---GYLSPEVLRKDPYGK 192 Query: 519 RSDVWSYGVTMWEALSYGQKPY 540 D+W+ GV ++ L G P+ Sbjct: 193 PVDLWACGVILY-ILLVGYPPF 213 >4XBR-A nrPDB Length = 366 Score = 58.9 bits (141), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 49/209 (23%), Positives = 87/209 (41%), Gaps = 14/209 (6%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 I++G G+ G V R K + V L++ + E + E IM + +V + Sbjct: 100 IKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR---ELLFNEVVIMRDYQHENVVEM 156 Query: 402 IG-VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 + L +VME GG L + R + +A + V + L + +HR Sbjct: 157 YNSYLVGDELWVVMEFLEGGALTDIVTHTR--MNEEQIAAVCLAVLQALSVLHAQGVIHR 214 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRS 520 D+ + ++LL + K+SDFG + + + + W APE I+ + Sbjct: 215 DIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY---WMAPELISRLPYGPEV 271 Query: 521 DVWSYGVTMWEALS-----YGQKPYKKMK 544 D+WS G+ + E + + + P K MK Sbjct: 272 DIWSLGIMVIEMVDGEPPYFNEPPLKAMK 300 >4BGQ-A nrPDB Length = 304 Score = 58.9 bits (141), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 52/198 (26%), Positives = 88/198 (44%), Gaps = 14/198 (7%) Query: 349 FGSVRQGVY------RMRKKQIDVAIKVLKQGTEKADTEEM-MREAQIMHQLDNPYIVRL 401 G V +G Y R ++ VAIK K E + +E +RE +++ L IV L Sbjct: 17 LGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVEL 76 Query: 402 IGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 + L LV E L + L +P V ++Q+ + + + + VHR Sbjct: 77 KEAFRRRGKLYLVFEYVEKNML-ELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHR 135 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALG-ADDSYYTARSAGKWPLKWYAPECINFRKFSSR 519 D+ N+L+ + K+ DFG ++ L +++ Y A +W + +PE + + Sbjct: 136 DIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRW---YRSPELLLGAPYGKS 192 Query: 520 SDVWSYGVTMWEALSYGQ 537 D+WS G + E LS GQ Sbjct: 193 VDMWSVGCILGE-LSDGQ 209 >4JDH-A nrPDB Length = 346 Score = 58.9 bits (141), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 49/209 (23%), Positives = 87/209 (41%), Gaps = 14/209 (6%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 I++G G+ G V R K + V L++ + E + E IM + +V + Sbjct: 80 IKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR---ELLFNEVVIMRDYQHENVVEM 136 Query: 402 IG-VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 + L +VME GG L + R + +A + V + L + +HR Sbjct: 137 YNSYLVGDELWVVMEFLEGGALTDIVTHTR--MNEEQIAAVCLAVLQALSVLHAQGVIHR 194 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRS 520 D+ + ++LL + K+SDFG + + + + W APE I+ + Sbjct: 195 DIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY---WMAPELISRLPYGPEV 251 Query: 521 DVWSYGVTMWEALS-----YGQKPYKKMK 544 D+WS G+ + E + + + P K MK Sbjct: 252 DIWSLGIMVIEMVDGEPPYFNEPPLKAMK 280 >4B6L-A nrPDB Length = 281 Score = 58.5 bits (140), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 48/191 (25%), Positives = 85/191 (44%), Gaps = 8/191 (4%) Query: 367 AIKVLKQG--TEKADTEEMMREAQIMHQLDNPYIVRLIGVCQ-AEALMLVMEMAGGGPLH 423 A+KV+ Q + E+++ E ++ L + +IVR + A+ + + +E+ L Sbjct: 38 AVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSL- 96 Query: 424 KFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLS 483 + R + V L Q+ G+KYL ++ +HRDL N + K+ DFGL+ Sbjct: 97 AHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLA 156 Query: 484 KALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKM 543 L + ++ P + APE + + +DVWS G M+ L G P++ Sbjct: 157 ARLEPPEQ--RKKTICGTP-NYVAPEVLLRQGHGPEADVWSLGCVMYTLLC-GSPPFETA 212 Query: 544 KGPEVMAFIEQ 554 E I+Q Sbjct: 213 DLKETYRCIKQ 223 >2Q0N-A nrPDB Length = 301 Score = 58.5 bits (140), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 49/209 (23%), Positives = 87/209 (41%), Gaps = 14/209 (6%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 I++G G+ G V R K + V L++ + E + E IM + +V + Sbjct: 35 IKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR---ELLFNEVVIMRDYQHENVVEM 91 Query: 402 IG-VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 + L +VME GG L + R + +A + V + L + +HR Sbjct: 92 YNSYLVGDELWVVMEFLEGGALTDIVTHTR--MNEEQIAAVCLAVLQALSVLHAQGVIHR 149 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRS 520 D+ + ++LL + K+SDFG + + + + W APE I+ + Sbjct: 150 DIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY---WMAPELISRLPYGPEV 206 Query: 521 DVWSYGVTMWEALS-----YGQKPYKKMK 544 D+WS G+ + E + + + P K MK Sbjct: 207 DIWSLGIMVIEMVDGEPPYFNEPPLKAMK 235 >3GC0-A nrPDB Length = 329 Score = 58.5 bits (140), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 52/199 (26%), Positives = 92/199 (46%), Gaps = 15/199 (7%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QGTEKADTEEMMREAQIMHQLDNPYIVRL 401 +LG G +G V + + + + VAIK ++ + E+ +RE ++ +L + I+ L Sbjct: 41 KLGEGTYGEVYKAIDTVTNET--VAIKRIRLEHEEEGVPGTAIREVSLLKELQHRNIIEL 98 Query: 402 IGVCQ-AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 V L L+ E A L K++ K ++ + + L+Q+ G+ + + +HR Sbjct: 99 KSVIHHNHRLHLIFEYAEND-LKKYM-DKNPDVSMRVIKSFLYQLINGVNFCHSRRCLHR 156 Query: 461 DLAARNVLLVNRHYA-----KISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC-INFR 514 DL +N+LL + KI DFGL++A G +T W + PE + R Sbjct: 157 DLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLW---YRPPEILLGSR 213 Query: 515 KFSSRSDVWSYGVTMWEAL 533 +S+ D+WS E L Sbjct: 214 HYSTSVDIWSIACIWAEML 232 >5D7A-A nrPDB Length = 308 Score = 58.2 bits (139), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 55/202 (27%), Positives = 88/202 (43%), Gaps = 21/202 (10%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIM-----HQLDNPYI 398 +G G +G V +G R K AIKV+ + + EE+ +E ++ H+ Y Sbjct: 25 VGNGTYGQVYKG--RHVKTGQLAAIKVMDVTGD--EEEEIKQEINMLKKYSHHRNIATYY 80 Query: 399 VRLIGVC---QAEALMLVMEMAGGGPLHKFLVG-KREEIPVSNVAELLHQVSMGMKYLEE 454 I + L LVME G G + + K + +A + ++ G+ +L + Sbjct: 81 GAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 140 Query: 455 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR 514 +HRD+ +NVLL K+ DFG+S L D R+ W APE I Sbjct: 141 HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQL---DRTVGRRNTFIGTPYWMAPEVIACD 197 Query: 515 K-----FSSRSDVWSYGVTMWE 531 + + +SD+WS G+T E Sbjct: 198 ENPDATYDFKSDLWSLGITAIE 219 >3OHT-A nrPDB Length = 389 Score = 58.2 bits (139), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 50/201 (24%), Positives = 96/201 (47%), Gaps = 22/201 (10%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKA-DTEEMMREAQIMHQLDNPYIVRLI 402 +G G +GSV Y + K + +A+K L + + + RE +++ + + ++ L+ Sbjct: 59 VGSGAYGSVCSS-YDV-KSGLKIAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLL 116 Query: 403 GVC-------QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK 455 V + + LV + G + + K +++ +V L++Q+ G+KY+ Sbjct: 117 DVFTPATSLEEFNDVYLVTHLMGADLNN---IVKCQKLTDDHVQFLIYQILRGLKYIHSA 173 Query: 456 NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APEC-INF 513 + +HRDL N+ + KI DFGL++ + + Y A +WY APE +N+ Sbjct: 174 DIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVAT-------RWYRAPEIMLNW 226 Query: 514 RKFSSRSDVWSYGVTMWEALS 534 ++ D+WS G M E L+ Sbjct: 227 MHYNMTVDIWSVGCIMAELLT 247 >5U06-A nrPDB Length = 120 Score = 58.2 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 34/99 (34%), Positives = 54/99 (54%), Gaps = 4/99 (4%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHF---PIERQLN 66 +F+G ISR E++ + G+ DGLFL+R+ R+ G+VLSL H + H+ P E + Sbjct: 19 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 78 Query: 67 GTYAIAGGKAH-CGPAELCEFYSRDPDGLPCNLRKPCNR 104 +++ G+ +L EF+ + LPC LR C R Sbjct: 79 LYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTR 117 Score = 55.8 bits (133), Expect = 5e-08, Method: Composition-based stats. Identities = 38/115 (33%), Positives = 62/115 (53%), Gaps = 8/115 (6%) Query: 146 APQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRP--RKEQGTYALSLI 203 +P ++ H W+H ++REE++R + DG FL+R R QG + LSL Sbjct: 2 SPASGTSLSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQG-FVLSLC 60 Query: 204 YGKTVYHYLI-SQDKAGK--YCIPEG-TKFDTLWQLVEYLKLKADGLIYCLKEAC 254 + + V HYLI ++ G+ + + +G T+F L QLVE+ +L G++ CL C Sbjct: 61 HLQKVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNR-GILPCLLRHC 114 >4I6B-A nrPDB Length = 308 Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 55/244 (22%), Positives = 100/244 (40%), Gaps = 7/244 (2%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LG G F + K I + ++ E++ +E ++ L + ++V+ Sbjct: 36 LGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHHKHVVQFYH 95 Query: 404 VCQ-AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 + E + +++E + L R+ + V L Q+ G+KYL E+ +HRDL Sbjct: 96 YFEDKENIYILLEYCSRRSMAHILKA-RKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDL 154 Query: 463 AARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDV 522 N + K+ DFGL+ L + + R+ P + +PE +N + + SD+ Sbjct: 155 KLGNFFINESMELKVGDFGLAARLEPLE--HRRRTICGTP-NYLSPEVLNKQGHGAESDI 211 Query: 523 WSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWED 582 W+ G M+ L G+ P++ E I + R P L++ ED Sbjct: 212 WALGCVMYTML-LGRPPFETTNLKETYRSIREA-RYTMPSSLLAPAKHLIASMLSKNPED 269 Query: 583 RPDF 586 RP Sbjct: 270 RPSL 273 >2JAM-A nrPDB Length = 304 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 58/226 (25%), Positives = 100/226 (44%), Gaps = 15/226 (6%) Query: 334 RDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL 393 R + ++ LG G F V R+ K A+K +K+ D+ + E ++ ++ Sbjct: 8 RKTFIFMEV-LGSGAFSEVFLVKQRLTGKLF--ALKCIKKSPAFRDSS-LENEIAVLKKI 63 Query: 394 DNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYL 452 + IV L + ++ LVM++ GG L ++ +R + + ++ QV +KYL Sbjct: 64 KHENIVTLEDIYESTTHYYLVMQLVSGGELFDRIL-ERGVYTEKDASLVIQQVLSAVKYL 122 Query: 453 EEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPE 509 E VHRDL N+L + I+DFGLSK + G + APE Sbjct: 123 HENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPG-----YVAPE 177 Query: 510 CINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG 555 + + +S D WS GV + L G P+ + ++ I++G Sbjct: 178 VLAQKPYSKAVDCWSIGVITYILLC-GYPPFYEETESKLFEKIKEG 222 >4EWQ-A nrPDB Length = 383 Score = 57.8 bits (138), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 50/201 (24%), Positives = 94/201 (46%), Gaps = 22/201 (10%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKA-DTEEMMREAQIMHQLDNPYIVRLI 402 +G G +GSV K + VA+K L + + + RE +++ + + ++ L+ Sbjct: 53 VGSGAYGSVCAAFDT--KTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLL 110 Query: 403 GVC-------QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK 455 V + + LV + G + + K +++ +V L++Q+ G+KY+ Sbjct: 111 DVFTPARSLEEFNDVYLVTHLMGADLNN---IVKCQKLTDDHVQFLIYQILRGLKYIHSA 167 Query: 456 NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APEC-INF 513 + +HRDL N+ + KI DFGL++ + + Y A +WY APE +N+ Sbjct: 168 DIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVAT-------RWYRAPEIMLNW 220 Query: 514 RKFSSRSDVWSYGVTMWEALS 534 ++ D+WS G M E L+ Sbjct: 221 MHYNQTVDIWSVGCIMAELLT 241 >3C51-A nrPDB Length = 543 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 51/195 (26%), Positives = 91/195 (46%), Gaps = 7/195 (3%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LG G FG V + K K+ ++ + M E +I+ ++ + +IV L Sbjct: 193 LGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSLAY 252 Query: 404 VCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLH---QVSMGMKYLEEKNFVH 459 + + L LVM + GG + + E+ P + Q+ G+++L ++N ++ Sbjct: 253 AFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNIIY 312 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 519 RDL NVLL + +ISD GL+ L A + T AG + APE + ++ Sbjct: 313 RDLKPENVLLDDDGNVRISDLGLAVELKAGQT-KTKGYAGT--PGFMAPELLLGEEYDFS 369 Query: 520 SDVWSYGVTMWEALS 534 D ++ GVT++E ++ Sbjct: 370 VDYFALGVTLYEMIA 384 >4U41-A nrPDB Length = 332 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 39/130 (30%), Positives = 60/130 (46%), Gaps = 9/130 (6%) Query: 408 EALMLVMEMAGGGPLHKFLVG-KREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARN 466 + L LVME G G + + K + +A + ++ G+ +L + +HRD+ +N Sbjct: 100 DQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQN 159 Query: 467 VLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK-----FSSRSD 521 VLL K+ DFG+S L D R+ W APE I + + RSD Sbjct: 160 VLLTENAEVKLVDFGVSAQL---DRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSD 216 Query: 522 VWSYGVTMWE 531 +WS G+T E Sbjct: 217 LWSCGITAIE 226 >2F9G-A nrPDB Length = 353 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 49/201 (24%), Positives = 93/201 (46%), Gaps = 17/201 (8%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LG G +G V ++ + VAIK ++ + +RE +I+ + I+ + Sbjct: 19 LGEGAYGVVCSATHKPTGEI--VAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFN 76 Query: 404 VCQAEAL-----MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 + + ++ + +++ LH+ V + + ++ ++Q +K L N + Sbjct: 77 IQRPDSFENFNEVYIIQELMQTDLHR--VISTQMLSDDHIQYFIYQTLRAVKVLHGSNVI 134 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKAL---GADDSYYTARSAGKW---PLKWY-APEC- 510 HRDL N+L+ + K+ DFGL++ + AD+S T + +G +WY APE Sbjct: 135 HRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVM 194 Query: 511 INFRKFSSRSDVWSYGVTMWE 531 + K+S DVWS G + E Sbjct: 195 LTSAKYSRAMDVWSCGCILAE 215 >2AUG-A nrPDB Length = 126 Score = 56.2 bits (134), Expect = 4e-08, Method: Composition-based stats. Identities = 34/103 (33%), Positives = 56/103 (54%), Gaps = 7/103 (6%) Query: 158 HERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYHYLI--- 213 H PW+H ++R+EA+R + DG FL+R + T+ LS+ +G+ + H+ I Sbjct: 23 HRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPV 82 Query: 214 SQDKAGKYCIPEG-TKFDTLWQLVEYLKLKADGLIYC-LKEAC 254 D + + +G T+F L QLVE+ +L G++ C LK C Sbjct: 83 EDDGEMFHTLDDGHTRFTDLIQLVEFYQLN-KGVLPCKLKHYC 124 Score = 53.9 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 32/100 (32%), Positives = 49/100 (49%), Gaps = 4/100 (4%) Query: 9 PFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHF---PIERQL 65 P+F+ ISR EA+ + G+ DG+FL+R + +VLS+ H + HF P+E Sbjct: 27 PWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVEDDG 86 Query: 66 NGTYAIAGGKAH-CGPAELCEFYSRDPDGLPCNLRKPCNR 104 + + G +L EFY + LPC L+ C R Sbjct: 87 EMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCAR 126 >2OU7-A nrPDB Length = 335 Score = 56.2 bits (134), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 39/148 (26%), Positives = 65/148 (43%), Gaps = 17/148 (11%) Query: 394 DNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 DN ++ ++ +C+ +L+ LHK +R+ + L Q+ +G +YL Sbjct: 112 DNDFVFVVLELCRRRSLL---------ELHK----RRKALTEPEARYYLRQIVLGCQYLH 158 Query: 454 EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF 513 +HRDL N+ L KI DFGL+ + D + APE ++ Sbjct: 159 RNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTP---NYIAPEVLSK 215 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPYK 541 + S DVWS G M+ L G+ P++ Sbjct: 216 KGHSFEVDVWSIGCIMY-TLLVGKPPFE 242 >1CM8-A nrPDB Length = 367 Score = 56.2 bits (134), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 52/200 (26%), Positives = 93/200 (46%), Gaps = 20/200 (10%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 +G G +G+V V + VAIK L + + + RE +++ + + ++ L+ Sbjct: 33 VGSGAYGAVCSAVDG--RTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90 Query: 403 GVCQAEALM-------LVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK 455 V + + LVM G L K + K E++ + L++Q+ G++Y+ Sbjct: 91 DVFTPDETLDDFTDFYLVMPFMGTD-LGKLM--KHEKLGEDRIQFLVYQMLKGLRYIHAA 147 Query: 456 NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFR 514 +HRDL N+ + KI DFGL++ DS T +W + APE I N+ Sbjct: 148 GIIHRDLKPGNLAVNEDCELKILDFGLARQA---DSEMTGYVVTRW---YRAPEVILNWM 201 Query: 515 KFSSRSDVWSYGVTMWEALS 534 +++ D+WS G M E ++ Sbjct: 202 RYTQTVDIWSVGCIMAEMIT 221 >4J52-A nrPDB Length = 293 Score = 56.2 bits (134), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 39/148 (26%), Positives = 65/148 (43%), Gaps = 17/148 (11%) Query: 394 DNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 DN ++ ++ +C+ +L+ LHK +R+ + L Q+ +G +YL Sbjct: 85 DNDFVFVVLELCRRRSLL---------ELHK----RRKALTEPEARYYLRQIVLGCQYLH 131 Query: 454 EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF 513 +HRDL N+ L KI DFGL+ + D + APE ++ Sbjct: 132 RNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTP---NYIAPEVLSK 188 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPYK 541 + S DVWS G M+ L G+ P++ Sbjct: 189 KGHSFEVDVWSIGCIMY-TLLVGKPPFE 215 >6BFN-A nrPDB Length = 342 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 53/216 (24%), Positives = 94/216 (43%), Gaps = 20/216 (9%) Query: 341 DIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE---KADTEEMMREAQIMHQLDNPY 397 ++++G G FG V YR + A+K LK+ + A + + E + + + +P Sbjct: 27 ELKIGEGGFGCV----YRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPN 82 Query: 398 IVRLIGVCQAEAL-MLVMEMAGGGPLHKFLVGKREEIPV---SNVAELLHQVSMGMKYLE 453 IV G C LV G L L + + P ++L + +++L Sbjct: 83 IVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLH 142 Query: 454 EKN--FVHRDLAARNVLLVNRHYAKISDFGLSK-----ALGADDSYYTARSAG-KWPLKW 505 + + +H D+ + NVLL R K+ DFGL++ S AR+ + L + Sbjct: 143 QDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAY 202 Query: 506 YAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYK 541 E I + + +D +S+GV + E L+ GQ+ K Sbjct: 203 LPEEYIKTGRLAVDTDTFSFGVVVLETLA-GQRAVK 237 >4PWN-A nrPDB Length = 274 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 57/214 (26%), Positives = 105/214 (49%), Gaps = 20/214 (9%) Query: 337 LLIADIELGCGNFGSVRQGVYRMRKKQIDVA-IKVLKQGTEKADTEEMMREAQIMHQLDN 395 L DIE+G G+F +V +G+ + ++VA ++ + K++ + EA+++ L + Sbjct: 11 FLKFDIEIGRGSFKTVYKGLD--TETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQH 68 Query: 396 PYIVRLIG-----VCQAEALMLVMEMAGGGPLHKFLVGKREEI-PVSNVAELLHQVSMGM 449 P IVR V + ++LV E+ G L +L KR ++ + + Q+ G+ Sbjct: 69 PNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYL--KRFKVMKIKVLRSWCRQILKGL 126 Query: 450 KYLEEKN--FVHRDLAARNVLLVN-RHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY 506 ++L + +HRDL N+ + KI D GL+ L S+ A+S P ++ Sbjct: 127 QFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLA-TLEKRASF--AKSVIGTP-EFM 182 Query: 507 APECINFRKFSSRSDVWSYGVTMWEALSYGQKPY 540 APE K+ DV+++G+ M E ++ + PY Sbjct: 183 APEMYE-EKYDESVDVYAFGMCMLE-MATSEYPY 214 >4G3E-A nrPDB Length = 352 Score = 55.1 bits (131), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 60/208 (28%), Positives = 94/208 (45%), Gaps = 15/208 (7%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G G+FG V +RM+ KQ V K E EE++ A L +P IV L G Sbjct: 82 VGRGSFGEV----HRMKDKQTGFQCAVKKVRLEVFRVEELVACAG----LSSPRIVPLYG 133 Query: 404 -VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 V + + + ME+ GG L + L+ + +P L Q G++YL + +H D+ Sbjct: 134 AVREGPWVNIFMELLEGGSLGQ-LIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDV 192 Query: 463 AARNVLL-VNRHYAKISDFGLSKALGADDSYYTARSAGKWP--LKWYAPECINFRKFSSR 519 A NVLL + A + DFG + L D + + P APE + + ++ Sbjct: 193 KADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCDAK 252 Query: 520 SDVWSYGVTMWEALSYGQKPYKK-MKGP 546 D+WS M L+ G P+ + +GP Sbjct: 253 VDIWSSCCMMLHMLN-GCHPWTQYFRGP 279 >4LQP-A nrPDB Length = 508 Score = 55.1 bits (131), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 45/155 (29%), Positives = 76/155 (49%), Gaps = 8/155 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMR-EAQIMHQLDNPYIVRLI 402 +G G FG VR V + +I +LK K D ++ E ++ D+P++V L Sbjct: 110 IGKGAFGEVRL-VQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSPWVVSLY 168 Query: 403 GVCQ-AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAEL-LHQVSMGMKYLEEKNFVHR 460 Q A+ L L+ME GG L L+ R ++ +V + + + ++ + + F+HR Sbjct: 169 YSFQDAQYLYLIMEFLPGGDLMTMLI--RWQLFTEDVTRFYMAECILAIETIHKLGFIHR 226 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGA--DDSYY 493 + N+L+ R + K+SDFGLS D +YY Sbjct: 227 AIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYY 261 >3HKO-A nrPDB Length = 345 Score = 55.1 bits (131), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 59/255 (23%), Positives = 101/255 (39%), Gaps = 50/255 (19%) Query: 344 LGCGNFGSVRQGVYRMRK--KQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 +G G++G VR + + + I + K + D E + E ++M +L +P I RL Sbjct: 34 IGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKLHHPNIARL 93 Query: 402 IGVCQAEA-LMLVMEMAGGGPL-----------------------------------HKF 425 V + E + LVME+ GG L + Sbjct: 94 YEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECNEEAINGS 153 Query: 426 LVGKREEIPVSN----VAELLHQVSMGMKYLEEKNFVHRDLAARNVLL-VNRHY-AKISD 479 + G RE + ++ ++ Q+ + YL + HRD+ N L N+ + K+ D Sbjct: 154 IHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKSFEIKLVD 213 Query: 480 FGLSKALGA--DDSYYTARSAGKWPLKWYAPECINF--RKFSSRSDVWSYGVTMWEALSY 535 FGLSK + YY + P + APE +N + + D WS GV + L Sbjct: 214 FGLSKEFYKLNNGEYYGMTTKAGTPY-FVAPEVLNTTNESYGPKCDAWSAGV-LLHLLLM 271 Query: 536 GQKPYKKMKGPEVMA 550 G P+ + + ++ Sbjct: 272 GAVPFPGVNDADTIS 286 >6ED6-A nrPDB Length = 415 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 55/227 (24%), Positives = 98/227 (43%), Gaps = 14/227 (6%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLK--QGTEKADTEEMMREAQIMHQLDNPYIVRL 401 +G G FG V+ + R + Q A+K+L + +++D+ E IM ++P++V+L Sbjct: 96 IGRGAFGEVQ--LVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQL 153 Query: 402 IGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 Q + L +VME GG L + ++P +V + + + +HR Sbjct: 154 FYAFQDDRYLYMVMEYMPGGDLVNLM--SNYDVPEKWAKFYTAEVVLALDAIHSMGLIHR 211 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK----F 516 D+ N+LL + K++DFG + + + G P + +PE + + + Sbjct: 212 DVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGT-P-DYISPEVLKSQGGDGFY 269 Query: 517 SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE 563 D WS GV ++E L G P+ + I K C PE Sbjct: 270 GRECDWWSVGVFLYEML-VGDTPFYADSLVGTYSKIMDHKNSLCFPE 315 >1NRV-A nrPDB Length = 105 Score = 54.3 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 32/99 (32%), Positives = 49/99 (49%), Gaps = 4/99 (4%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHF---PIERQLN 66 +F+G ISR E+ +K G+ DGLFLLR + +VL+L H + +F P E Sbjct: 7 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 66 Query: 67 GTYAIAGGKAHCGP-AELCEFYSRDPDGLPCNLRKPCNR 104 +++ G +L +FY + LPC L+ C R Sbjct: 67 TFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIR 105 Score = 46.2 bits (108), Expect = 5e-05, Method: Composition-based stats. Identities = 31/103 (30%), Positives = 52/103 (50%), Gaps = 7/103 (6%) Query: 158 HERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYHYLI--- 213 H W+H ++REE+ R + DG FLLR + + L+L + + + ++ I Sbjct: 2 HRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPC 61 Query: 214 SQDKAGKYCIPEG-TKFDTLWQLVEYLKLKADGLIYC-LKEAC 254 D + + +G TKF L QLV++ +L G++ C LK C Sbjct: 62 EDDGQTFFSLDDGNTKFSDLIQLVDFYQLN-KGVLPCKLKHHC 103 >3FXW-A nrPDB Length = 336 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 37/147 (25%), Positives = 69/147 (46%), Gaps = 20/147 (13%) Query: 396 PYIVRLIGVCQ-----AEALMLVMEMAGGGPLHKFLVGKREE-IPVSNVAELLHQVSMGM 449 P+IV ++ V + L+++ME GG L + + ++ AE++ + + Sbjct: 82 PHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAI 141 Query: 450 KYLEEKNFVHRDLAARNVLLVNRH---YAKISDFGLSKALGADDSYYTARSAGKWPL--- 503 ++L N HRD+ N+L ++ K++DFG +K T ++A + P Sbjct: 142 QFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKE--------TTQNALQTPCYTP 193 Query: 504 KWYAPECINFRKFSSRSDVWSYGVTMW 530 + APE + K+ D+WS GV M+ Sbjct: 194 YYVAPEVLGPEKYDKSCDMWSLGVIMY 220 >6E9W-A nrPDB Length = 443 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 50/204 (24%), Positives = 93/204 (45%), Gaps = 14/204 (6%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLK--QGTEKADTEEMMREAQIMHQLDNPYIVRL 401 +G G FG V+ + R + + A+K+L + +++D+ E IM ++P++V+L Sbjct: 110 IGRGAFGEVQ--LVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQL 167 Query: 402 IGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 Q + L +VME GG L + ++P +V + + + F+HR Sbjct: 168 FYAFQDDRYLYMVMEYMPGGDLVNLM--SNYDVPEKWARFYTAEVVLALDAIHSMGFIHR 225 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK----F 516 D+ N+LL + K++DFG + + + G P + +PE + + + Sbjct: 226 DVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGT-P-DYISPEVLKSQGGDGYY 283 Query: 517 SSRSDVWSYGVTMWEALSYGQKPY 540 D WS GV ++E L G P+ Sbjct: 284 GRECDWWSVGVFLYEML-VGDTPF 306 >1JNK-A nrPDB Length = 423 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 46/182 (25%), Positives = 81/182 (44%), Gaps = 22/182 (12%) Query: 365 DVAIKVLKQGTE-KADTEEMMREAQIMHQLDNPYIVRLIGVC-------QAEALMLVMEM 416 +VAIK L + + + + RE +M +++ I+ L+ V + + + LVME+ Sbjct: 89 NVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMEL 148 Query: 417 AGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAK 476 + E+ ++ LL+Q+ G+K+L +HRDL N+++ + K Sbjct: 149 MDANLCQVI----QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLK 204 Query: 477 ISDFGLSKALGAD---DSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEAL 533 I DFGL++ G Y R + APE I + D+WS G M E + Sbjct: 205 ILDFGLARTAGTSFMMTPYVVTRY-------YRAPEVILGMGYKENVDIWSVGCIMGEMV 257 Query: 534 SY 535 + Sbjct: 258 RH 259 >5UUU-A nrPDB Length = 547 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 57/242 (23%), Positives = 106/242 (43%), Gaps = 26/242 (10%) Query: 344 LGCGNFGSVRQGVYRMRK---------KQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 +G G FG V Y RK K +D +KQG A E +M ++ D Sbjct: 206 IGRGGFGEV----YGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM--LSLVSTGD 259 Query: 395 NPYIVRL-IGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 P+IV + + L ++++ GG LH + + + +++ ++ +G++++ Sbjct: 260 CPFIVCMSYAFHTPDKLSFILDLMNGGDLH-YHLSQHGVFSEADMRFYAAEIILGLEHMH 318 Query: 454 EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN- 512 + V+RDL N+LL + +ISD GL+ + + + G + APE + Sbjct: 319 NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----YMAPEVLQK 373 Query: 513 FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM--ECPPECPPELYA 570 + S +D +S G +++ L G P+++ K + M E P PEL + Sbjct: 374 GVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 432 Query: 571 LM 572 L+ Sbjct: 433 LL 434 >1TKI-A nrPDB Length = 321 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 53/206 (25%), Positives = 99/206 (48%), Gaps = 13/206 (6%) Query: 338 LIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPY 397 +IA+ +LG G FG V + V KK +A V +GT++ + +E I++ + Sbjct: 8 MIAE-DLGRGEFGIVHRCVETSSKKTY-MAKFVKVKGTDQVLVK---KEISILNIARHRN 62 Query: 398 IVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 I+ L ++ E L+++ E G + + + E+ + +HQV +++L N Sbjct: 63 ILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHN 122 Query: 457 FVHRDLAARNVLLVNRHYA--KISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR 514 H D+ N++ R + KI +FG ++ L D++ +A ++YAPE Sbjct: 123 IGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAP----EYYAPEVHQHD 178 Query: 515 KFSSRSDVWSYGVTMWEALSYGQKPY 540 S+ +D+WS G ++ LS G P+ Sbjct: 179 VVSTATDMWSLGTLVYVLLS-GINPF 203 >5O2C-A nrPDB Length = 380 Score = 53.5 bits (127), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 63/248 (25%), Positives = 109/248 (43%), Gaps = 41/248 (16%) Query: 337 LLIADIELGCGNFGSVRQGVYRMRKKQIDVA-IKVLKQGTEKADTEEMMREAQIMHQLDN 395 L DIELG G F +V +G+ + ++VA ++ + KA+ + EA+++ L + Sbjct: 26 FLKFDIELGRGAFKTVYKGLDT--ETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQH 83 Query: 396 PYIVRLIGVCQA-----EALMLVMEMAGGGPLHKFLVGKREEIPVSNVA-ELLHQVSMGM 449 P IVR ++ + ++LV E+ G L +L KR ++ V Q+ G+ Sbjct: 84 PNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYL--KRFKVMKPKVLRSWCRQILKGL 141 Query: 450 KYLEEKN--FVHRDLAARNVLLVN-RHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY 506 ++L + +HRDL N+ + KI D GL+ + A+S P ++ Sbjct: 142 QFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTS----FAKSVIGTP-EFM 196 Query: 507 APECINFRKFSSRSDVWSYGVTMWE-------------------ALSYGQKP--YKKMKG 545 APE + DV+++G+ M E ++ G KP + K+ Sbjct: 197 APEMYE-EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTD 255 Query: 546 PEVMAFIE 553 PEV IE Sbjct: 256 PEVKEIIE 263 >1PHK-A nrPDB Length = 298 Score = 53.5 bits (127), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 65/236 (27%), Positives = 99/236 (41%), Gaps = 24/236 (10%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDV-AIKVLKQGTEKADTEEMMREA-----QIMHQLD-NP 396 LG G VR+ +++ K+ V I V G+ A+ + +REA I+ ++ +P Sbjct: 25 LGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDILRKVSGHP 84 Query: 397 YIVRLIGVCQAEALM-LVMEMAGGGPLHKFLVGK--REEIPVSNVAELLHQVSMGMKYLE 453 I++L + LV ++ G L +L K E + L +V + L Sbjct: 85 NIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEVICALHKL- 143 Query: 454 EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-- 511 N VHRDL N+LL + K++DFG S L D R P + APE I Sbjct: 144 --NIVHRDLKPENILLDDDMNIKLTDFGFSCQL---DPGEKLREVCGTP-SYLAPEIIEC 197 Query: 512 ----NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE 563 N + D+WS GV M+ L+ G P+ K ++ I G PE Sbjct: 198 SMNDNHPGYGKEVDMWSTGVIMYTLLA-GSPPFWHRKQMLMLRMIMSGNYQFGSPE 252 >2H34-A nrPDB Length = 309 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 56/245 (22%), Positives = 105/245 (42%), Gaps = 11/245 (4%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQ--GTEKADTEEMMREAQIMHQLDNPYIVRL 401 +G G G V + +R++ VA+K++ + ++ M REA+ +L P++V + Sbjct: 42 VGRGGMGDVYEAEDTVRERI--VALKLMSETLSSDPVFRTRMQREARTAGRLQEPHVVPI 99 Query: 402 IGVCQAEALMLV-MEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 + + + V M + G L L + P VA ++ Q+ + HR Sbjct: 100 HDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVA-IVRQIGSALDAAHAAGATHR 158 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRS 520 D+ N+L+ +A + DFG++ A D T L + APE + + R+ Sbjct: 159 DVKPENILVSADDFAYLVDFGIASA--TTDEKLTQLGNTVGTLYYMAPERFSESHATYRA 216 Query: 521 DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG--KRMECPPECPPELYALMSDCWIY 578 D+++ ++E L+ G PY+ + + A I Q + P P A+++ Sbjct: 217 DIYALTCVLYECLT-GSPPYQGDQLSVMGAHINQAIPRPSTVRPGIPVAFDAVIARGMAK 275 Query: 579 KWEDR 583 EDR Sbjct: 276 NPEDR 280 >5O2B-A nrPDB Length = 285 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 56/214 (26%), Positives = 101/214 (47%), Gaps = 21/214 (9%) Query: 337 LLIADIELGCGNFGSVRQGVYRMRKKQIDVA-IKVLKQGTEKADTEEMMREAQIMHQLDN 395 L DIELG G F +V +G+ + ++VA ++ + KA+ + EA+++ L + Sbjct: 17 FLKFDIELGRGAFKTVYKGLDT--ETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQH 74 Query: 396 PYIVRLIGVCQA-----EALMLVMEMAGGGPLHKFLVGKREEIPVSNVA-ELLHQVSMGM 449 P IVR ++ + ++LV E+ G L +L KR ++ V Q+ G+ Sbjct: 75 PNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYL--KRFKVMKPKVLRSWCRQILKGL 132 Query: 450 KYLEEKN--FVHRDLAARNVLLVN-RHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY 506 ++L + +HRDL N+ + KI D GL+ + A+S P ++ Sbjct: 133 QFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTS----FAKSVIGTP-EFM 187 Query: 507 APECINFRKFSSRSDVWSYGVTMWEALSYGQKPY 540 APE + DV+++G+ M E ++ + PY Sbjct: 188 APEMYE-EHYDESVDVYAFGMCMLE-MATSEYPY 219 >5AIR-A nrPDB Length = 430 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 62/207 (29%), Positives = 94/207 (45%), Gaps = 34/207 (16%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL-- 401 +G G+FG V Q ++ VAIK + Q D RE QIM +LD+ IVRL Sbjct: 72 IGNGSFGVVYQA--KLCDSGELVAIKKVLQ-----DKRFKNRELQIMRKLDHCNIVRLRY 124 Query: 402 ----IGVCQAEA-LMLVMEMAGGGPLHKFLVGK-----REEIPVSNVAELLHQVSMGMKY 451 G + E L LV++ P + V + ++ +PV V ++Q+ + Y Sbjct: 125 FFYSSGEKKDEVYLNLVLDYV---PETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 181 Query: 452 LEEKNFVHRDLAARNVLL-VNRHYAKISDFGLSKALGADD---SYYTARSAGKWPLKWYA 507 + HRD+ +N+LL + K+ DFG +K L + SY +R + A Sbjct: 182 IHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY-------YRA 234 Query: 508 PECI-NFRKFSSRSDVWSYGVTMWEAL 533 PE I ++S DVWS G + E L Sbjct: 235 PELIFGATDYTSSIDVWSAGCVLAELL 261 >5J0A-A nrPDB Length = 300 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 39/161 (24%), Positives = 78/161 (48%), Gaps = 9/161 (5%) Query: 383 MMREAQIMHQLDNPYIVRLIGVCQAE--ALMLVMEMAGGGPLHKFL----VGKREEIPVS 436 +M EA+I+ L +P IV +A +L L ME G L+ + ++ P + Sbjct: 61 LMDEAKILKSLHHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAA 120 Query: 437 NVAELLHQVSMGMKYL-EEKNFVHRDLAARNVLLV-NRHYAKISDFGLSKALGADDSYYT 494 + ++ ++ G+KYL +EK +H D+ + NV++ + KI D G+S L + Sbjct: 121 IILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTD 180 Query: 495 ARSAGKWPLKWYAPECINFRK-FSSRSDVWSYGVTMWEALS 534 + W E + + ++D++++G+T+WE ++ Sbjct: 181 PEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMT 221 >2PLE-A nrPDB Length = 105 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 30/81 (37%), Positives = 44/81 (54%), Gaps = 3/81 (3%) Query: 158 HERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDK 217 HE WYH+SLTR +AE L DG FL+R R E +YA+S + H + Q+ Sbjct: 6 HESKEWYHASLTRAQAEHMLMR-VPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE- 63 Query: 218 AGKYCIPEGTKFDTLWQLVEY 238 G+ + ++FD+L L+ Y Sbjct: 64 -GQTVMLGNSEFDSLVDLISY 83 >3FI2-A nrPDB Length = 353 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 46/182 (25%), Positives = 81/182 (44%), Gaps = 22/182 (12%) Query: 365 DVAIKVLKQGTE-KADTEEMMREAQIMHQLDNPYIVRLIGVC-------QAEALMLVMEM 416 +VAIK L + + + + RE +M +++ I+ L+ V + + + LVME+ Sbjct: 51 NVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMEL 110 Query: 417 AGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAK 476 + E+ ++ LL+Q+ G+K+L +HRDL N+++ + K Sbjct: 111 MDANLCQVI----QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLK 166 Query: 477 ISDFGLSKALGAD---DSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEAL 533 I DFGL++ G Y R + APE I + D+WS G M E + Sbjct: 167 ILDFGLARTAGTSFMMTPYVVTRY-------YRAPEVILGMGYKENVDIWSVGCIMGEMV 219 Query: 534 SY 535 + Sbjct: 220 RH 221 >4C0T-A nrPDB Length = 974 Score = 53.1 bits (126), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 46/207 (22%), Positives = 95/207 (45%), Gaps = 10/207 (4%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPY-IVRL 401 ELG G++ +V ++ KQ V + + ++ + + E +++L N ++ L Sbjct: 273 ELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNRLGVISL 332 Query: 402 IGVCQ-AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 Q ++L V++ A G L L+ + + Q+ +KY+ + +HR Sbjct: 333 YFTFQDKDSLYFVLDYASNGELLT-LIKRYNTLNEECTRHFGAQILDAIKYMHDNGVIHR 391 Query: 461 DLAARNVLLVNRHYAKISDFG----LSKALGADDSYYTARSAGKW--PLKWYAPECINFR 514 DL N+LL ++ +I+DFG L K + Y A + ++ +PE + + Sbjct: 392 DLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVSPELLENK 451 Query: 515 KFSSRSDVWSYGVTMWEALSYGQKPYK 541 DVW++G +++ ++ G+ P+K Sbjct: 452 YCGKPGDVWAFGCIIYQMIA-GKPPFK 477 >3G2F-A nrPDB Length = 336 Score = 53.1 bits (126), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 70/250 (28%), Positives = 106/250 (42%), Gaps = 41/250 (16%) Query: 332 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEK--ADTEEMMREAQI 389 L DNL + ++ +G G +G+V +G R VA+KV + + + + R + Sbjct: 10 LDLDNLKLLEL-IGRGRYGAVYKGSLDERP----VAVKVFSFANRQNFINEKNIYRVPLM 64 Query: 390 MHQLDNPYIV---RLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVS 446 H +IV R+ + E L LVME G L K+L + S L H V+ Sbjct: 65 EHDNIARFIVGDERVTADGRMEYL-LVMEYYPNGSLCKYLSLHTSDWVSS--CRLAHSVT 121 Query: 447 MGMKYLEEK---------NFVHRDLAARNVLLVNRHYAKISDFGLSKAL--------GAD 489 G+ YL + HRDL +RNVL+ N ISDFGLS L G + Sbjct: 122 RGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEE 181 Query: 490 DSYYTARSAGKWPLKWYAPEC----INFRKFSS---RSDVWSYGVTMWEALSYGQKPYKK 542 D+ + +++ APE +N R S + D+++ G+ WE + Sbjct: 182 DNAAISEVG---TIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPG 238 Query: 543 MKGPEV-MAF 551 PE MAF Sbjct: 239 ESVPEYQMAF 248 >3PVW-A nrPDB Length = 695 Score = 52.8 bits (125), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 57/242 (23%), Positives = 106/242 (43%), Gaps = 26/242 (10%) Query: 344 LGCGNFGSVRQGVYRMRK---------KQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 +G G FG V Y RK K +D +KQG A E +M ++ D Sbjct: 197 IGRGGFGEV----YGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM--LSLVSTGD 250 Query: 395 NPYIVRL-IGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 P+IV + + L ++++ GG LH + + + +++ ++ +G++++ Sbjct: 251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLH-YHLSQHGVFSEADMRFYAAEIILGLEHMH 309 Query: 454 EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN- 512 + V+RDL N+LL + +ISD GL+ + + + G + APE + Sbjct: 310 NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG-----YMAPEVLQK 364 Query: 513 FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM--ECPPECPPELYA 570 + S +D +S G +++ L G P+++ K + M E P PEL + Sbjct: 365 GVAYDSSADWFSLGCMLFKLLR-GHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 423 Query: 571 LM 572 L+ Sbjct: 424 LL 425 >2XS0-A nrPDB Length = 386 Score = 52.8 bits (125), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 58/229 (25%), Positives = 99/229 (43%), Gaps = 36/229 (15%) Query: 333 KRDNLLIADIELGCGNF------------GSVRQGVYRMRKKQI---DVAIKVLKQGTE- 376 KRDN + +E+G F GS QG+ I +VAIK L + + Sbjct: 7 KRDNNFYS-VEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 65 Query: 377 KADTEEMMREAQIMHQLDNPYIVRLIGVC-------QAEALMLVMEMAGGGPLHKFLVGK 429 + + RE +M +++ I+ L+ V + + + +VME+ Sbjct: 66 QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVI---- 121 Query: 430 REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD 489 + E+ ++ LL+Q+ G+K+L +HRDL N+++ + KI DFGL++ G Sbjct: 122 QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG-- 179 Query: 490 DSYYTARSAGKWPLKWY--APECINFRKFSSRSDVWSYGVTMWEALSYG 536 T+ + + Y APE I + D+WS G M E + G Sbjct: 180 ----TSFMMVPFVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGG 224 >3QD2-B nrPDB Length = 332 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 29/99 (29%), Positives = 49/99 (49%), Gaps = 9/99 (9%) Query: 444 QVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYT--------A 495 Q++ +++L K +HRDL N+ K+ DFGL A+ D+ T A Sbjct: 172 QIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYA 231 Query: 496 RSAGKWPLKWY-APECINFRKFSSRSDVWSYGVTMWEAL 533 G+ K Y +PE I+ +S + D++S G+ ++E L Sbjct: 232 THTGQVGTKLYMSPEQIHGNNYSHKVDIFSLGLILFELL 270 Score = 29.3 bits (64), Expect = 5.7, Method: Compositional matrix adjust. Identities = 17/57 (29%), Positives = 32/57 (56%), Gaps = 2/57 (3%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVR 400 +G G FG V + + + + AIK ++ + E++MRE + + +L++P IVR Sbjct: 14 MGRGGFGVVFEA--KNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVR 68 >4MYG-A nrPDB Length = 372 Score = 52.4 bits (124), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 51/202 (25%), Positives = 93/202 (46%), Gaps = 15/202 (7%) Query: 339 IADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE-KADTEEMMREAQIMHQLDNPY 397 ++ +G G +GSV + + ++ VAIK L + + + + RE ++ + + Sbjct: 46 VSPTHVGSGAYGSVCSAIDKRSGEK--VAIKKLSRPFQSEIFAKRAYRELLLLKHMQHEN 103 Query: 398 IVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVGK--REEIPVSNVAELLHQVSMGMKYLEE 454 ++ L+ V A +L + P + + K E + L++Q+ G+KY+ Sbjct: 104 VIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHS 163 Query: 455 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APECI-N 512 VHRDL N+ + KI DFGL++ A+ + Y +WY APE I + Sbjct: 164 AGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVT-------RWYRAPEVILS 216 Query: 513 FRKFSSRSDVWSYGVTMWEALS 534 + ++ D+WS G M E L+ Sbjct: 217 WMHYNQTVDIWSVGCIMAEMLT 238 >2RIO-A nrPDB Length = 434 Score = 52.4 bits (124), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 61/235 (25%), Positives = 101/235 (42%), Gaps = 39/235 (16%) Query: 336 NLLIADIELGCGNFGSVR-----QG----VYRMRKKQIDVAIKVLKQGTEKADTEEMMRE 386 NL++++ LG G+ G+V QG V RM D+A+ +K TE D ++R Sbjct: 15 NLVVSEKILGYGSSGTVVFQGSFQGRPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIR- 73 Query: 387 AQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVS 446 + + ++ + +C LV K ++E P+S LL Q++ Sbjct: 74 -YYCSETTDRFLYIALELCNLNLQDLVESKNVSDENLKL---QKEYNPIS----LLRQIA 125 Query: 447 MGMKYLEEKNFVHRDLAARNVLL--VNRHYAK-----------ISDFGLSKALGA-DDSY 492 G+ +L +HRDL +N+L+ +R A ISDFGL K L + S+ Sbjct: 126 SGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSF 185 Query: 493 YTARSAGKWPLKWYAPECI-------NFRKFSSRSDVWSYGVTMWEALSYGQKPY 540 T + W APE + R+ + D++S G + LS G+ P+ Sbjct: 186 RTNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF 240 >4QNY-A nrPDB Length = 354 Score = 52.4 bits (124), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 46/208 (22%), Positives = 92/208 (44%), Gaps = 23/208 (11%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTE-----EMMREAQIMHQLDNPYI 398 +G G++G V R R + D + +K+ ++ E ++RE +++ ++ I Sbjct: 28 IGAGSYGVV----IRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFNDDNI 83 Query: 399 VRLIGVCQAEA------LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYL 452 + L + E +VM++ K ++ +E+ +++ ++Q + + Sbjct: 84 IGLRNILTPEDPENFDHFYIVMDIMETDL--KQVLRSGQELTEAHIQFFIYQALRALHII 141 Query: 453 EEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI- 511 +HRD+ N+L+ KI DFGL+K Y T +W + APE + Sbjct: 142 HSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRW---YRAPELVM 198 Query: 512 NFRKFSSRSDVWSYGVTMWEALSYGQKP 539 + +S++ DVW G + E L G +P Sbjct: 199 EDKDYSAQIDVWGIGCILGELL--GSRP 224 >4O2Z-A nrPDB Length = 377 Score = 52.0 bits (123), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 34/111 (30%), Positives = 54/111 (48%), Gaps = 6/111 (5%) Query: 430 REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD 489 R+ + S++ ++Q+ G+KYL N HRDL N++ KI DFGLS+++ Sbjct: 144 RQVLEESHMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVP 203 Query: 490 DSYYTARSAGKWPLKWYAPE-CINFRKFSSRSDVWSYGVTMWEALSYGQKP 539 S T +W + PE + +S+ D+WS G E Y +KP Sbjct: 204 YSELTDYVITRW---YRPPELLLENTNYSTAVDIWSVGCIFAEM--YNRKP 249 >3OZ6-A nrPDB Length = 388 Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 92/217 (42%), Gaps = 33/217 (15%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD-NPYIVRL 401 +LG G +G V + + R R ++ K+ D + RE I+ +L + IV L Sbjct: 16 KLGKGAYGIVWKSIDR-RTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSGHENIVNL 74 Query: 402 IGVCQAEA---LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 + V +A+ + LV + LH + E PV +++Q+ +KYL + Sbjct: 75 LNVLRADNDRDVYLVFDYMETD-LHAVIRANILE-PVHK-QYVVYQLIKVIKYLHSGGLL 131 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKA---------------------LGADDSYYTARS 497 HRD+ N+LL + K++DFGLS++ D T Sbjct: 132 HRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQPILTDYV 191 Query: 498 AGKWPLKWYAPEC-INFRKFSSRSDVWSYGVTMWEAL 533 A +W + APE + K++ D+WS G + E L Sbjct: 192 ATRW---YRAPEILLGSTKYTKGIDMWSLGCILGEIL 225 >5AWM-A nrPDB Length = 394 Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 46/183 (25%), Positives = 82/183 (44%), Gaps = 18/183 (9%) Query: 363 QIDVAIKVLKQGTEKAD-TEEMMREAQIMHQLDNPYIVRLIGVC-------QAEALMLVM 414 Q +VAIK L + + + RE ++M +++ I+ L+ + + + LVM Sbjct: 69 QQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVM 128 Query: 415 EMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHY 474 E+ + ++ ++ LL+Q+ G+K+L +HRDL N+++ Sbjct: 129 ELMDANLCQVI----QMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCT 184 Query: 475 AKISDFGLSKALGADDSYYTARSAGKWPLKWY-APECINFRKFSSRSDVWSYGVTMWEAL 533 KI DFGL++ G T ++Y APE I ++ D+WS G M E + Sbjct: 185 LKILDFGLARTAGT-----TFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMI 239 Query: 534 SYG 536 G Sbjct: 240 RGG 242 >4X7Q-B nrPDB Length = 312 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 63/257 (24%), Positives = 115/257 (44%), Gaps = 31/257 (12%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG-----TEKADTEEMMREAQIMHQLD---- 394 LG G FG+V G +R+ + + VAIKV+ + + +D+ E ++ ++ Sbjct: 39 LGKGGFGTVFAG-HRLTDR-LQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGG 96 Query: 395 NPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAE--LLHQVSMGMKY 451 +P ++RL+ + E MLV+E P E+ P+ QV +++ Sbjct: 97 HPGVIRLLDWFETQEGFMLVLERPL--PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQH 154 Query: 452 LEEKNFVHRDLAARNVLL-VNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510 + VHRD+ N+L+ + R AK+ DFG S AL D+ Y + PE Sbjct: 155 CHSRGVVHRDIKDENILIDLRRGCAKLIDFG-SGALLHDEPYTDFDGT----RVYSPPEW 209 Query: 511 INFRKFSSR-SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELY 569 I+ ++ + + VWS G+ +++ + G P+++ + E++ + P P+ Sbjct: 210 ISRHQYHALPATVWSLGILLYDMVC-GDIPFERDQ--EILE-----AELHFPAHVSPDCC 261 Query: 570 ALMSDCWIYKWEDRPDF 586 AL+ C K RP Sbjct: 262 ALIRRCLAPKPSSRPSL 278 >1PY5-A nrPDB Length = 326 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 69/289 (23%), Positives = 120/289 (41%), Gaps = 55/289 (19%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMH--QLDNPYIVRL 401 +G G FG V +G +R +VA+K+ E++ REA+I L + I+ Sbjct: 37 IGKGRFGEVWRGKWRGE----EVAVKIFSSREERS----WFREAEIYQTVMLRHENILGF 88 Query: 402 IGVCQAE-----ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK- 455 I + L LV + G L +L R + V + +L + G+ +L + Sbjct: 89 IAADNKDNGTWTQLWLVSDYHEHGSLFDYL--NRYTVTVEGMIKLALSTASGLAHLHMEI 146 Query: 456 -------NFVHRDLAARNVLLVNRHYAKISDFGLS-KALGADDSYYTARSAGKWPLKWYA 507 HRDL ++N+L+ I+D GL+ + A D+ A + ++ A Sbjct: 147 VGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMA 206 Query: 508 PEC----INFRKFSS--RSDVWSYGVTMWEA---LSYG------QKPYKKM--KGPEVMA 550 PE IN + F S R+D+++ G+ WE S G Q PY + P V Sbjct: 207 PEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSV-- 264 Query: 551 FIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYS 599 E+ +++ C + P + +W+ + + MR C+Y+ Sbjct: 265 --EEMRKVVCEQKLRPNIPN--------RWQSCEALRVMAKIMRECWYA 303 >1GRI-A nrPDB Length = 217 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 29/78 (37%), Positives = 47/78 (60%), Gaps = 3/78 (3%) Query: 162 PWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYHYLISQDKAGK 220 PW+ + R +AE L S + DG FL+R + G ++LS+ +G V H+ + +D AGK Sbjct: 59 PWFFGKIPRAKAEEML-SKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGK 117 Query: 221 YCIPEGTKFDTLWQLVEY 238 Y + KF++L +LV+Y Sbjct: 118 YFL-WVVKFNSLNELVDY 134 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 23/63 (36%), Positives = 33/63 (52%), Gaps = 1/63 (1%) Query: 9 PFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGT 68 P+F+G I RA+AEE L DG FL+R+ + G + LS+ HF + R G Sbjct: 59 PWFFGKIPRAKAEEMLS-KQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGK 117 Query: 69 YAI 71 Y + Sbjct: 118 YFL 120 >4TN6-A nrPDB Length = 318 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 66/278 (23%), Positives = 115/278 (41%), Gaps = 35/278 (12%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ++G G+FG + G +++ + ++ +K ++ E++I + + I Sbjct: 14 KIGSGSFGDIYLGTDIAAGEEVAIKLECVK-----TKHPQLHIESKIYKMMQGGVGIPTI 68 Query: 403 GVCQAEALMLVMEMAGGGP-LHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 C AE VM M GP L + + V L Q+ ++Y+ KNF+HRD Sbjct: 69 RWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRD 128 Query: 462 LAARNVLL---VNRHYAKISDFGLSKALGADDSYYTARSAGKWPLK---------WYAPE 509 + N L+ + I DFGL+K Y AR+ P + YA Sbjct: 129 VKPDNFLMGLGKKGNLVYIIDFGLAK------KYRDARTHQHIPYRENKNLTGTARYASI 182 Query: 510 CINFR-KFSSRSDVWSYG-VTMWEALSYGQKPYKKMKGPEVMAFIEQ--GKRMECPPEC- 564 + + S R D+ S G V M+ L G P++ +K E+ K+M P E Sbjct: 183 NTHLGIEQSRRDDLESLGYVLMYFNL--GSLPWQGLKAATKRQKYERISEKKMSTPIEVL 240 Query: 565 ----PPELYALMSDCWIYKWEDRPDFLTVEQRMRACYY 598 P E ++ C +++D+PD+ + Q R ++ Sbjct: 241 CKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFH 278 >3E7O-A nrPDB Length = 360 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 43/178 (24%), Positives = 82/178 (46%), Gaps = 16/178 (8%) Query: 364 IDVAIKVLKQGTE-KADTEEMMREAQIMHQLDNPYIVRLIGVC-------QAEALMLVME 415 I+VA+K L + + + + RE ++ +++ I+ L+ V + + + LVME Sbjct: 48 INVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVME 107 Query: 416 MAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYA 475 + E+ ++ LL+Q+ G+K+L +HRDL N+++ + Sbjct: 108 LMDANLCQVI----HMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL 163 Query: 476 KISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEAL 533 KI DFGL++ + + T ++ + APE I + D+WS G M E + Sbjct: 164 KILDFGLART-ASTNFMMTPYVVTRY---YRAPEVILGMGYKENVDIWSVGCIMGELV 217 >3M42-A nrPDB Length = 299 Score = 49.7 bits (117), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 48/209 (22%), Positives = 89/209 (42%), Gaps = 43/209 (20%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 D+ + LG G G V Q ++ R ++ A+K+L+ D + RE ++ + Sbjct: 17 DDYKVTSQVLGLGINGKVLQ-IFNKRTQE-KFALKMLQ------DCPKARREVELHWRAS 68 Query: 395 N-PYIVRLIGVCQA-----EALMLVMEMAGGGPLHKFLVGKREE-IPVSNVAELLHQVSM 447 P+IVR++ V + + L++VME GG L + + ++ +E++ + Sbjct: 69 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 128 Query: 448 GMKYLEEKNFVHRDLAARNVLLVNRH---YAKISDFGLSKALGADDSYYTARSAGKWPLK 504 ++YL N HRD+ N+L ++ K++DFG +K + Sbjct: 129 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTGE--------------- 173 Query: 505 WYAPECINFRKFSSRSDVWSYGVTMWEAL 533 K+ D+WS GV M+ L Sbjct: 174 ----------KYDKSCDMWSLGVIMYILL 192 >3MDY-A nrPDB Length = 337 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 70/290 (24%), Positives = 121/290 (41%), Gaps = 46/290 (15%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKAD---TEEMMREAQIMHQLDNPYIV 399 ++G G +G V G +R K VA+KV TE+A E+ + + H+ +I Sbjct: 44 QIGKGRYGEVWMGKWRGEK----VAVKVFFT-TEEASWFRETEIYQTVLMRHENILGFIA 98 Query: 400 RLI-GVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNF- 457 I G L L+ + G L+ +L K + ++ +L + G+ +L + F Sbjct: 99 ADIKGTGSWTQLYLITDYHENGSLYDYL--KSTTLDAKSMLKLAYSSVSGLCHLHTEIFS 156 Query: 458 -------VHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP-- 508 HRDL ++N+L+ I+D GL+ +D + + K Y P Sbjct: 157 TQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE 216 Query: 509 ---ECINFRKFSS--RSDVWSYGVTMWEA----LSYG-----QKPYKKMK----GPEVMA 550 E +N F S +D++S+G+ +WE +S G Q PY + E M Sbjct: 217 VLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMR 276 Query: 551 FIEQGKRME-------CPPECPPELYALMSDCWIYKWEDRPDFLTVEQRM 593 I K++ EC ++ LM++CW + R L V++ + Sbjct: 277 EIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTL 326 >3REP-A nrPDB Length = 271 Score = 49.3 bits (116), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 55/243 (22%), Positives = 102/243 (41%), Gaps = 22/243 (9%) Query: 356 VYRMRKKQIDVAIKVLK-QGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQ---AEALM 411 +++ R + D+ +KVLK + + + E + +P ++ ++G CQ A Sbjct: 26 LWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPAPHPT 85 Query: 412 LVMEMAGGGPLHKFL-VGKREEIPVSNVAELLHQVSMGMKYLE--EKNFVHRDLAARNVL 468 L+ G L+ L G + S + ++ GM +L E L +R+V+ Sbjct: 86 LITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVM 145 Query: 469 LVNRHYAKISDFGLSKALGADDSYYTARSAGK-WPLKWYAPECINFRKFSSR---SDVWS 524 + A+IS D ++ +S G+ + W APE + + + +D+WS Sbjct: 146 IDEDMTARIS---------MADVKFSFQSPGRMYAPAWVAPEALQKKPEDTNRRSADMWS 196 Query: 525 YGVTMWEALSYGQKPYKKMKGPEV-MAFIEQGKRMECPPECPPELYALMSDCWIYKWEDR 583 + V +WE ++ + P+ + E+ M +G R PP P + LM C R Sbjct: 197 FAVLLWELVTR-EVPFADLSNMEIGMKVALEGLRPTIPPGISPHVSKLMKICMNEDPAKR 255 Query: 584 PDF 586 P F Sbjct: 256 PKF 258 >5TUR-A nrPDB Length = 404 Score = 49.3 bits (116), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 59/264 (22%), Positives = 113/264 (42%), Gaps = 37/264 (14%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT-----EKADTEEMMREAQIMHQLDNPY- 397 LG G FGSV G+ + VAIK +++ E + + E ++ ++ + + Sbjct: 135 LGSGGFGSVYSGI--RVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFS 192 Query: 398 -IVRLIGVCQ-AEALMLVMEMAGGGPLHKF--LVGKREEIPVSNVAELLHQVSMGMKYLE 453 ++RL+ + ++ +L++E P+ + +R + QV +++ Sbjct: 193 GVIRLLDWFERPDSFVLILERP--EPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH 250 Query: 454 EKNFVHRDLAARNVLL-VNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN 512 +HRD+ N+L+ +NR K+ DFG L D+ YT + + PE I Sbjct: 251 NCGVLHRDIKDENILIDLNRGELKLIDFGSGALL--KDTVYTDFDGTR---VYSPPEWIR 305 Query: 513 FRKFSSRS-DVWSYGVTMWEALSYGQKPYKK----MKGPEVMAFIEQGKRMECPPECPPE 567 + ++ RS VWS G+ +++ + G P++ ++G F Q EC Sbjct: 306 YHRYHGRSAAVWSLGILLYDMVC-GDIPFEHDEEIIRG---QVFFRQRVSSEC------- 354 Query: 568 LYALMSDCWIYKWEDRPDFLTVEQ 591 L+ C + DRP F ++ Sbjct: 355 -QHLIRWCLALRPSDRPTFEEIQN 377 >2LCT-A nrPDB Length = 107 Score = 49.3 bits (116), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 32/91 (35%), Positives = 47/91 (51%), Gaps = 4/91 (4%) Query: 1 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP 60 M D + HL ++ G + RA AE LA +DG FL+RQ ++ + +S+ ++V H Sbjct: 3 MQDLSVHL-WYAGPMERAGAES--ILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIK 59 Query: 61 IERQLNGTYAIAGGKAHCGPAELCEFYSRDP 91 I G Y I KA G EL EFY ++ Sbjct: 60 I-MTAEGLYRITEKKAFRGLTELVEFYQQNS 89 >5FQD-C nrPDB Length = 341 Score = 48.5 bits (114), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 70/291 (24%), Positives = 122/291 (41%), Gaps = 57/291 (19%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN----PYI 398 ++G G+FG + + +++ V ++ ++KA +++ E+++ L P+I Sbjct: 26 KIGSGSFGDIYLAINITNGEEVAVKLE-----SQKARHPQLLYESKLYKILQGGVGIPHI 80 Query: 399 VRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 R G + + +LVM++ G F R + V L Q+ ++Y+ KNF+ Sbjct: 81 -RWYGQ-EKDYNVLVMDLLGPSLEDLFNFCSRR-FTMKTVLMLADQMISRIEYVHTKNFI 137 Query: 459 HRDLAARNVLL-VNRHYAKIS--DFGLSKALGADDSYYTARSAGKWPLK---------WY 506 HRD+ N L+ + RH K+ DFGL+K Y R+ P + Y Sbjct: 138 HRDIKPDNFLMGIGRHCNKLFLIDFGLAK------KYRDNRTRQHIPYREDKNLTGTARY 191 Query: 507 APECINFR---KFSSRSDVWSYGVTM---------WEALSYGQKPYKKMKGPEVMAFIEQ 554 A IN + S R D+ S G + W+ L K K K E Sbjct: 192 A--SINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISE------- 242 Query: 555 GKRMECPPEC-----PPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL 600 K+M P E P E ++ C ++E+ PD++ + Q R + +L Sbjct: 243 -KKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTL 292 >2CRH-A nrPDB Length = 138 Score = 48.5 bits (114), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 35/108 (32%), Positives = 51/108 (47%), Gaps = 9/108 (8%) Query: 3 DPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIE 62 D + HL ++ G + RA AE L A +DG FL+RQ ++ + +S+ ++V H I Sbjct: 22 DLSVHL-WYAGPMERAGAESIL--ANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKI- 77 Query: 63 RQLNGTYAIAGGKAHCGPAELCEFYSRDP-----DGLPCNLRKPCNRP 105 G Y I KA G EL EFY ++ L L+ P P Sbjct: 78 MTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEP 125 >5L2Q-C nrPDB Length = 320 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 32/116 (27%), Positives = 58/116 (50%), Gaps = 6/116 (5%) Query: 427 VGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNR-HYAKISDFGLSKA 485 V K + + + + V ++ L +KN VHRDL N++L R H I++F L K Sbjct: 144 VIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKH 203 Query: 486 LGADDSYYTARSAGKWPLKWYAPECINFRKFSSR-SDVWSYGVTMWEALSYGQKPY 540 L ++ + + +P+ ++ R + + SD+W+ GV ++ L YGQ P+ Sbjct: 204 LVSEGDLLKDQRGSP---AYISPDVLSGRPYRGKPSDMWALGVVLFTML-YGQFPF 255 >4Y83-A nrPDB Length = 332 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 42/148 (28%), Positives = 69/148 (46%), Gaps = 11/148 (7%) Query: 398 IVRLIG-VCQAEALMLVMEMAGGGPLHKFL--VGKREEIPVSNVAELLHQVSMGMKYLEE 454 I L G V E + L ME GG + + L G E + V + V G+ +L Sbjct: 127 IAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTK---HVLKGLDFLHS 183 Query: 455 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR 514 K +H D+ N++ ++ A + DFGLS + +D Y+ G + +PE I R Sbjct: 184 KKVIHHDIKPSNIVFMSTK-AVLVDFGLSVQM-TEDVYFPKDLRGTE--IYMSPEVILCR 239 Query: 515 KFSSRSDVWSYGVTMWEALSYGQKPYKK 542 S+++D++S G T+ + G P+ K Sbjct: 240 GHSTKADIYSLGATLIH-MQTGTPPWVK 266 >3BGP-A nrPDB Length = 333 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 59/264 (22%), Positives = 113/264 (42%), Gaps = 37/264 (14%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT-----EKADTEEMMREAQIMHQLDNPY- 397 LG G FGSV G+ + VAIK +++ E + + E ++ ++ + + Sbjct: 64 LGSGGFGSVYSGI--RVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFS 121 Query: 398 -IVRLIGVCQ-AEALMLVMEMAGGGPLHKF--LVGKREEIPVSNVAELLHQVSMGMKYLE 453 ++RL+ + ++ +L++E P+ + +R + QV +++ Sbjct: 122 GVIRLLDWFERPDSFVLILERP--EPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH 179 Query: 454 EKNFVHRDLAARNVLL-VNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN 512 +HRD+ N+L+ +NR K+ DFG L D+ YT + + PE I Sbjct: 180 NCGVLHRDIKDENILIDLNRGELKLIDFGSGALL--KDTVYTDFDGTR---VYSPPEWIR 234 Query: 513 FRKFSSRS-DVWSYGVTMWEALSYGQKPYKK----MKGPEVMAFIEQGKRMECPPECPPE 567 + ++ RS VWS G+ +++ + G P++ ++G F Q EC Sbjct: 235 YHRYHGRSAAVWSLGILLYDMVC-GDIPFEHDEEIIRG---QVFFRQRVSSEC------- 283 Query: 568 LYALMSDCWIYKWEDRPDFLTVEQ 591 L+ C + DRP F ++ Sbjct: 284 -QHLIRWCLALRPSDRPTFEEIQN 306 >4H1O-A nrPDB Length = 560 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 31/77 (40%), Positives = 41/77 (53%), Gaps = 3/77 (3%) Query: 163 WYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYHYLISQDKAGKY 221 W+H ++T EAE L + DG FL RP K G + LS+ V H I Q+ G Y Sbjct: 27 WFHPNITGVEAENLLLTRG-VDGSFLARPSKSNPGDFTLSVRRNGAVTHIKI-QNTGGYY 84 Query: 222 CIPEGTKFDTLWQLVEY 238 + G KF TL +LV+Y Sbjct: 85 DLYGGEKFATLAELVQY 101 Score = 45.8 bits (107), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 67/275 (24%), Positives = 106/275 (38%), Gaps = 77/275 (28%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69 +F+ +I+ EAE L G+ DG FL R + G + LS+ + H I+ G Y Sbjct: 27 WFHPNITGVEAENLLLTRGV-DGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQ-NTGGYY 84 Query: 70 AIAGGKAHCGPAELCEFYS------RDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAMV 123 + GG+ AEL ++Y ++ +G L+ P N Sbjct: 85 DLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLN-------------------- 124 Query: 124 RDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQT 183 A ER W+H L+ +EAE KL + Sbjct: 125 -----------------------------CADPTSER--WFHGHLSGKEAE-KLLTEKGK 152 Query: 184 DGKFLLRPRKEQ-GTYALSLIYG----------KTVYHYLISQDKAGKYCIPEGTKFDTL 232 G FL+R + G + LS+ G V H +I + KY + G +FD+L Sbjct: 153 HGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQEL-KYDVGGGERFDSL 211 Query: 233 WQLVEYLK----LKADGLIYCLKEACPNSSASNAS 263 LVE+ K ++ G + LK+ N++ NA+ Sbjct: 212 TDLVEHYKKNPMVETLGTVLQLKQPL-NTTRINAA 245 >4RC3-A nrPDB Length = 289 Score = 47.0 bits (110), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 59/264 (22%), Positives = 113/264 (42%), Gaps = 37/264 (14%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT-----EKADTEEMMREAQIMHQLDNPY- 397 LG G FGSV G+ + VAIK +++ E + + E ++ ++ + + Sbjct: 20 LGSGGFGSVYSGI--RVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFS 77 Query: 398 -IVRLIGVCQ-AEALMLVMEMAGGGPLHKF--LVGKREEIPVSNVAELLHQVSMGMKYLE 453 ++RL+ + ++ +L++E P+ + +R + QV +++ Sbjct: 78 GVIRLLDWFERPDSFVLILERP--EPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH 135 Query: 454 EKNFVHRDLAARNVLL-VNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN 512 +HRD+ N+L+ +NR K+ DFG L D+ YT + + PE I Sbjct: 136 NCGVLHRDIKDENILIDLNRGELKLIDFGSGALL--KDTVYTDFDGTR---VYSPPEWIR 190 Query: 513 FRKFSSRS-DVWSYGVTMWEALSYGQKPYKK----MKGPEVMAFIEQGKRMECPPECPPE 567 + ++ RS VWS G+ +++ + G P++ ++G F Q EC Sbjct: 191 YHRYHGRSAAVWSLGILLYDMVC-GDIPFEHDEEIIRG---QVFFRQRVSSEC------- 239 Query: 568 LYALMSDCWIYKWEDRPDFLTVEQ 591 L+ C + DRP F ++ Sbjct: 240 -QHLIRWCLALRPSDRPTFEEIQN 262 >2HW6-A nrPDB Length = 307 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 50/211 (23%), Positives = 87/211 (41%), Gaps = 19/211 (9%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD-NPYIVRLI 402 LG G + V+ V K+ V I + G ++ + RE + ++Q N I+ LI Sbjct: 21 LGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRS---RVFREVETLYQCQGNKNILELI 77 Query: 403 GVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 + + LV E GG + + K++ + ++ V+ + +L K HRD Sbjct: 78 EFFEDDTRFYLVFEKLQGGSILAH-IQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRD 136 Query: 462 LAARNVLLVNRHY---AKISDFGLSKALGADDSYYTAR----SAGKWPLKWYAPECINFR 514 L N+L + KI DF L + ++S + ++ APE + Sbjct: 137 LKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVF 196 Query: 515 K-----FSSRSDVWSYGVTMWEALSYGQKPY 540 + R D+WS GV ++ LS G P+ Sbjct: 197 TDQATFYDKRCDLWSLGVVLYIMLS-GYPPF 226 >2WTK-B nrPDB Length = 373 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 31/120 (25%), Positives = 56/120 (46%), Gaps = 11/120 (9%) Query: 438 VAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARS 497 +A +L V + Y+ +VHR + A ++L+ K+ GL L R Sbjct: 114 IAYILQGVLKALDYIHHMGYVHRSVKASHILISVD--GKVYLSGLRSNLSMISHGQRQRV 171 Query: 498 AGKWP------LKWYAPECI--NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVM 549 +P L W +PE + N + + ++SD++S G+T E L+ G P+K M +++ Sbjct: 172 VHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACE-LANGHVPFKDMPATQML 230 >2PMN-X nrPDB Length = 348 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 48/208 (23%), Positives = 94/208 (45%), Gaps = 17/208 (8%) Query: 377 KADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKF-----LVGKR 430 K+ ++ E QI+ + N Y + G+ + + ++ E + KF ++ K Sbjct: 84 KSKYDDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKN 143 Query: 431 EE--IPVSNVAELLHQVSMGMKYL-EEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALG 487 IP+ + ++ V Y+ EKN HRD+ N+L+ K+SDFG S+ + Sbjct: 144 YTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYM- 202 Query: 488 ADDSYYTARSAGKW-PLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYK-KMKG 545 D +R ++ P ++++ E ++ D+WS G+ ++ + Y P+ K+ Sbjct: 203 VDKKIKGSRGTYEFMPPEFFSNES---SYNGAKVDIWSLGICLY-VMFYNVVPFSLKISL 258 Query: 546 PEVMAFIEQGKRMECPPECPPELYALMS 573 E+ I + K +E P + LY L + Sbjct: 259 VELFNNI-RTKNIEYPLDRNHFLYPLTN 285 >1ZXE-A nrPDB Length = 303 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 45/220 (20%), Positives = 87/220 (39%), Gaps = 38/220 (17%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVR--- 400 LG G FG V + + + AIK ++ EK T ++ E ++ L++ Y+VR Sbjct: 14 LGQGAFGQVVKARNALDSRY--YAIKKIRHTEEKLST--ILSEVMLLASLNHQYVVRYYA 69 Query: 401 -----------LIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGM 449 + V + L + ME L+ + + L Q+ + Sbjct: 70 AWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQILEAL 129 Query: 450 KYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKAL---------------GADDSYYT 494 Y+ + +HR+L N+ + KI DFGL+K + G+ D+ + Sbjct: 130 SYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSSDNLTS 189 Query: 495 ARSAGKWPLKWYAPECINFR-KFSSRSDVWSYGVTMWEAL 533 A + A E ++ ++ + D++S G+ +E + Sbjct: 190 AIGTA----MYVATEVLDGTGHYNEKIDMYSLGIIFFEMI 225 >2EOB-A nrPDB Length = 124 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 29/86 (33%), Positives = 44/86 (51%), Gaps = 2/86 (2%) Query: 158 HERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDK 217 HE PWY+ L+R EAE L DG FL+R R+ +YA++ V H I++D Sbjct: 16 HESKPWYYDRLSRGEAEDMLMR-IPRDGAFLIRKREGTDSYAITFRARGKVKHCRINRD- 73 Query: 218 AGKYCIPEGTKFDTLWQLVEYLKLKA 243 + + F++L +LV Y + A Sbjct: 74 GRHFVLGTSAYFESLVELVSYYEKHA 99 Score = 31.6 bits (70), Expect = 1.1, Method: Compositional matrix adjust. Identities = 28/103 (27%), Positives = 45/103 (43%), Gaps = 5/103 (4%) Query: 2 PDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPI 61 P+P P++Y +SR EAE+ L + DG FL+R+ Y ++ + H I Sbjct: 13 PNPHESKPWYYDRLSRGEAEDML-MRIPRDGAFLIRK-REGTDSYAITFRARGKVKHCRI 70 Query: 62 ERQLNGTYAIAGGKAHCGP-AELCEFYSRDPDGLPCNLRKPCN 103 R +G + + G A+ EL +Y + LR P Sbjct: 71 NR--DGRHFVLGTSAYFESLVELVSYYEKHALYRKMRLRYPVT 111 >4E7W-A nrPDB Length = 394 Score = 45.4 bits (106), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 53/204 (25%), Positives = 87/204 (42%), Gaps = 29/204 (14%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G G+FG V Q + +VAIK + Q D RE QIM + +P +V L Sbjct: 48 IGNGSFGVVFQAKL---VESDEVAIKKVLQ-----DKRFKNRELQIMRIVKHPNVVDLKA 99 Query: 404 VCQAEA-------LMLVMEMAGGGPLH--KFLVGKREEIPVSNVAELLHQVSMGMKYLEE 454 + L LV+E + ++ +P+ + ++Q+ + Y+ Sbjct: 100 FFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAYIHS 159 Query: 455 KNFVHRDLAARNVLL-VNRHYAKISDFGLSKALGADD---SYYTARSAGKWPLKWYAPEC 510 HRD+ +N+LL K+ DFG +K L A + SY +R + APE Sbjct: 160 IGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRY-------YRAPEL 212 Query: 511 I-NFRKFSSRSDVWSYGVTMWEAL 533 I +++ D+WS G M E + Sbjct: 213 IFGATNYTTNIDIWSTGCVMAELM 236 >4CRL-A nrPDB Length = 406 Score = 45.4 bits (106), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 55/220 (25%), Positives = 94/220 (42%), Gaps = 44/220 (20%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ++G G +G V + + K D A+K + +GT + RE ++ +L +P ++ L Sbjct: 29 KVGRGTYGHVYKAKRKDGKDDKDYALKQI-EGT--GISMSACREIALLRELKHPNVISLQ 85 Query: 403 GVCQAEA---LMLVMEMAGGGPLH--KFLVGKRE-----EIPVSNVAELLHQVSMGMKYL 452 V + A + L+ + A H KF + ++P V LL+Q+ G+ YL Sbjct: 86 KVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYL 145 Query: 453 EEKNFVHRDLAARNVLLV----NRHYAKISDFGLSKALGADDSYYTARSAGKWPLK---- 504 +HRDL N+L++ R KI+D G ++ + PLK Sbjct: 146 HANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNS-------------PLKPLAD 192 Query: 505 --------WY-APE-CINFRKFSSRSDVWSYGVTMWEALS 534 WY APE + R ++ D+W+ G E L+ Sbjct: 193 LDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT 232 >3SOC-A nrPDB Length = 322 Score = 45.1 bits (105), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 41/141 (29%), Positives = 65/141 (46%), Gaps = 20/141 (14%) Query: 410 LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK----------NFVH 459 L L+ G L FL K + + + + ++ G+ YL E H Sbjct: 97 LWLITAFHEKGSLSDFL--KANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISH 154 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APEC----INFR 514 RD+ ++NVLL N A I+DFGL+ A S + G+ + Y APE INF+ Sbjct: 155 RDIKSKNVLLKNNLTACIADFGLALKFEAGKS--AGDTHGQVGTRRYMAPEVLEGAINFQ 212 Query: 515 KFSS-RSDVWSYGVTMWEALS 534 + + R D+++ G+ +WE S Sbjct: 213 RDAFLRIDMYAMGLVLWELAS 233 >2LQW-A nrPDB Length = 303 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 37/136 (27%), Positives = 60/136 (44%), Gaps = 5/136 (3%) Query: 157 AHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSLIYGKTVYHYLISQ 215 + +R WY ++R+EA+ +L Q G FL+R G Y LS+ V HY+I+ Sbjct: 8 SSDRSAWYMGPVSRQEAQTRLQ--GQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINS 65 Query: 216 DKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPS 275 ++ I + +FD L L+E+ K+ L E P + +AP LP Sbjct: 66 LPNRRFKIGD-QEFDHLPALLEFYKIHYLDTT-TLIEPAPRYPSPPMGSVSAPNLPTAED 123 Query: 276 TLTHPQRRIDTLNSDG 291 L + + D +D Sbjct: 124 NLEYVRTLYDFPGNDA 139 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 27/78 (34%), Positives = 39/78 (50%), Gaps = 3/78 (3%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69 ++ G +SR EA+ +L G G+FL+R G YVLS+ + R H+ I N + Sbjct: 14 WYMGPVSRQEAQ--TRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRF 71 Query: 70 AIAGGKAHCGPAELCEFY 87 I + PA L EFY Sbjct: 72 KIGDQEFDHLPA-LLEFY 88 >3Q4U-A nrPDB Length = 301 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 63/288 (21%), Positives = 117/288 (40%), Gaps = 55/288 (19%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEE-------MMREAQIMHQLDNP 396 +G G +G V +G ++ +VA+K+ EK+ E M+R I+ + + Sbjct: 16 VGKGRYGEVWRGSWQGE----NVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASD 71 Query: 397 YIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 R + L L+ G L+ +L + + + ++ ++ G+ +L + Sbjct: 72 MTSR----HSSTQLWLITHYHEMGSLYDYL--QLTTLDTVSCLRIVLSIASGLAHLHIEI 125 Query: 457 F--------VHRDLAARNVLLVNRHYAKISDFGL----SKALGADDSYYTARSAGKWPLK 504 F HRDL ++N+L+ I+D GL S++ D R K + Sbjct: 126 FGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTK---R 182 Query: 505 WYAPEC----INFRKFSS--RSDVWSYGVTMWEA----LSYG----QKPYKKMKGPEVMA 550 + APE I F S R D+W++G+ +WE +S G KP P + Sbjct: 183 YMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPS 242 Query: 551 FIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYY 598 F E +++ C + P + +W P ++ + M+ C+Y Sbjct: 243 F-EDMRKVVCVDQQRPNIPN--------RWFSDPTLTSLAKLMKECWY 281 >4C59-A nrPDB Length = 340 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 40/153 (26%), Positives = 70/153 (45%), Gaps = 21/153 (13%) Query: 406 QAEALMLVMEMAGGGPLHKFLVGKREEIPVS--NVAELLHQVSMGMKYLEEKN--FVHRD 461 QAE L+L E+ G L +FL P+S V ++ +Q ++++ + +HRD Sbjct: 105 QAEFLLLT-ELCKG-QLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRD 162 Query: 462 LAARNVLLVNRHYAKISDFGLSKALG--ADDSYYTARSA--------GKWPLKWYAPECI 511 L N+LL N+ K+ DFG + + D S+ R A P+ + PE I Sbjct: 163 LKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPM-YRTPEII 221 Query: 512 NFRK---FSSRSDVWSYGVTMWEALSYGQKPYK 541 + + D+W+ G ++ L + Q P++ Sbjct: 222 DLYSNFPIGEKQDIWALGCILY-LLCFRQHPFE 253 >3SV0-A nrPDB Length = 483 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 60/278 (21%), Positives = 117/278 (42%), Gaps = 37/278 (13%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPY---IV 399 ++G G+FG + G +++ + ++ +K +++ E++I L V Sbjct: 14 KIGSGSFGEIYLGTNIQTNEEVAIKLENVK-----TKHPQLLYESKIYRILQGGTGIPNV 68 Query: 400 RLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 R GV + + +LVM++ G F R+ + + V L Q+ ++++ K+F+H Sbjct: 69 RWFGV-EGDYNVLVMDLLGPSLEDLFNFCSRK-LSLKTVLMLADQMINRVEFVHSKSFLH 126 Query: 460 RDLAARNVLL-----VNRHYAKISDFGLSKALGADDSY----YTARSAGKWPLKWYAPEC 510 RD+ N L+ N+ Y I DFGL+K ++ Y ++ + Sbjct: 127 RDIKPDNFLMGLGRRANQVY--IIDFGLAKKYRDTSTHQHIPYRENKNLTGTARYASVNT 184 Query: 511 INFRKFSSRSDVWSYGVTM---------WEALSYGQK--PYKKMKGPEVMAFIEQGKRME 559 + S R D+ S G + W+ L G K Y+K+ +V IE R Sbjct: 185 HLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISEKKVATSIEALCR-- 242 Query: 560 CPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACY 597 P E + C +++D+PD+ +++ R + Sbjct: 243 ---GYPTEFASYFHYCRSLRFDDKPDYSYLKRLFRDLF 277 >3MY0-A nrPDB Length = 305 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 47/207 (22%), Positives = 87/207 (42%), Gaps = 26/207 (12%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN--PYIVR- 400 +G G +G V +G++ VA+K+ E++ E ++ + DN +I Sbjct: 16 VGKGRYGEVWRGLWHGES----VAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASD 71 Query: 401 LIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNF--- 457 + + L L+ G L+ FL +R+ + L + G+ +L + F Sbjct: 72 MTSRNSSTQLWLITHYHEHGSLYDFL--QRQTLEPHLALRLAVSAACGLAHLHVEIFGTQ 129 Query: 458 -----VHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APECI 511 HRD +RNVL+ + I+D GL+ Y + + K Y APE + Sbjct: 130 GKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVL 189 Query: 512 N-------FRKFSSRSDVWSYGVTMWE 531 + F + +D+W++G+ +WE Sbjct: 190 DEQIRTDCFESYKW-TDIWAFGLVLWE 215 >5VD3-A nrPDB Length = 311 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 39/163 (23%), Positives = 66/163 (40%), Gaps = 12/163 (7%) Query: 433 IPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSY 492 +P + V L + + +L + VH D+ N+ L R K+ DFGL LG Sbjct: 154 LPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAG-- 211 Query: 493 YTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI 552 A + ++ APE + + + +DV+S G+T+ E + P+ G E + Sbjct: 212 --AGEVQEGDPRYMAPELLQ-GSYGTAADVFSLGLTILEVACNMELPH----GGEGWQQL 264 Query: 553 EQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRA 595 QG PPE L + + + E P + + A Sbjct: 265 RQGY---LPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLA 304 >3RAW-A nrPDB Length = 381 Score = 42.4 bits (98), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 43/214 (20%), Positives = 86/214 (40%), Gaps = 35/214 (16%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL-----DNPYI 398 LG G FG V + + R K VA+K+++ + + + E ++ ++ +N ++ Sbjct: 59 LGEGTFGKVVECLDHARGKS-QVALKIIRNVGKYREAARL--EINVLKKIKEKDKENKFL 115 Query: 399 VRLIG--VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 L+ + + E+ G + P+ +V + +Q+ +++L E Sbjct: 116 CVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQ 175 Query: 457 FVHRDLAARNVLLVNRHY-------------------AKISDFGLSKALGADDSYYTARS 497 H DL N+L VN + +++DFG + D ++T Sbjct: 176 LTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFG---SATFDHEHHTTIV 232 Query: 498 AGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWE 531 A + + PE I ++ DVWS G ++E Sbjct: 233 ATR---HYRPPEVILELGWAQPCDVWSIGCILFE 263 >5UNP-A nrPDB Length = 369 Score = 42.4 bits (98), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 52/237 (21%), Positives = 92/237 (38%), Gaps = 36/237 (15%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL-----DNPYI 398 LG G FG V Q V R+ VA+K++K + + + E ++ ++ DN + Sbjct: 42 LGEGTFGRVVQCV-DHRRGGARVALKIIKNVEKYKEAARL--EINVLEKINEKDPDNKNL 98 Query: 399 -VRLIGVCQAEALMLV-MEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 V++ M + E+ G P+ V + Q+ +K+L + Sbjct: 99 CVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNK 158 Query: 457 FVHRDLAARNVLLVNRHY-------------------AKISDFGLSKALGADDSYYTARS 497 H DL N+L VN Y ++ DFG + D +++ Sbjct: 159 LTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFG---SATFDHEHHSTIV 215 Query: 498 AGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 554 + + + APE I +S DVWS G ++E G ++ E +A +E+ Sbjct: 216 STR---HYRAPEVILELGWSQPCDVWSIGCIIFEYYV-GFTLFQTHDNREHLAMMER 268 >5Y86-A nrPDB Length = 588 Score = 42.4 bits (98), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 49/201 (24%), Positives = 88/201 (43%), Gaps = 21/201 (10%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL---DNPYIVR 400 +G G+FG V + VY + +Q VA+K+++ EK + E +I+ L D + Sbjct: 215 IGKGSFGQVAR-VYDHKLRQY-VALKMVR--NEKRFHRQAAEEIRILEHLKKQDKTGSMN 270 Query: 401 LIGVCQA----EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 +I + ++ + + E+ K + V V + + + L + Sbjct: 271 VIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNK 330 Query: 457 FVHRDLAARNVLLVN--RHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY-APECINF 513 +H DL N+LL + R K+ DFG S Y +S ++Y APE I Sbjct: 331 IIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQKLYTYIQS------RFYRAPEIILG 383 Query: 514 RKFSSRSDVWSYGVTMWEALS 534 ++S+ D+WS+G + E L+ Sbjct: 384 SRYSTPIDIWSFGCILAELLT 404 >4IAN-A nrPDB Length = 358 Score = 42.0 bits (97), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 50/200 (25%), Positives = 89/200 (44%), Gaps = 25/200 (12%) Query: 345 GCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL------DNPYI 398 G G F +V + R Q +VA+K+++ T ++E + + +L D + Sbjct: 39 GQGVFSNVVRARDNARANQ-EVAVKIIRNNELMQKTG--LKELEFLKKLNDADPDDKFHC 95 Query: 399 VRLI-GVCQAEALMLVME---MAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 454 +RL + L LV E M L K+ GK + + V Q+ + +K L+ Sbjct: 96 LRLFRHFYHKQHLCLVFEPLSMNLREVLKKY--GKDVGLHIKAVRSYSQQLFLALKLLKR 153 Query: 455 KNFVHRDLAARNVLLV-NRHYAKISDFGLSKALGADDS--YYTARSAGKWPLKWYAPECI 511 N +H D+ N+L+ ++ K+ DFG + + +D Y +R + APE I Sbjct: 154 CNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRF-------YRAPEII 206 Query: 512 NFRKFSSRSDVWSYGVTMWE 531 + + D+WS G T++E Sbjct: 207 IGKSYDYGIDMWSVGCTLYE 226 >5E8V-A nrPDB Length = 316 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 38/142 (26%), Positives = 61/142 (42%), Gaps = 24/142 (16%) Query: 412 LVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN---------FVHRDL 462 L+ G L ++L R I ++ +L ++ G+ +L + VHRDL Sbjct: 90 LITAFHAKGNLQEYLT--RHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDL 147 Query: 463 AARNVLLVNRHYAKISDFGLS----KALGADDSYYTARSAGKWPLKWYAPECI----NFR 514 + N+L+ N + DFGLS L DD A S ++ APE + N Sbjct: 148 KSSNILVKNDLTCCLCDFGLSLRLDPTLSVDD---LANSGQVGTARYMAPEVLASAMNLE 204 Query: 515 KFSS--RSDVWSYGVTMWEALS 534 S ++DV+S + +WE S Sbjct: 205 NVESFKQTDVYSMALVLWEMTS 226 >2EKX-A nrPDB Length = 110 Score = 41.2 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 24/95 (25%), Positives = 48/95 (50%), Gaps = 7/95 (7%) Query: 163 WYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGK------TVYHYLISQD 216 W+ +++R ++E+ L + +G F++R + G Y +SL TV HY + + Sbjct: 13 WFAGNISRSQSEQLLRQKGK-EGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTN 71 Query: 217 KAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLK 251 K + E FD++ +L+ Y + + G+I L+ Sbjct: 72 AENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLR 106 >4M4Z-A nrPDB Length = 170 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 31/98 (31%), Positives = 43/98 (43%), Gaps = 5/98 (5%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSL-----VHDVRFHHFPIERQ 64 + Y +SR +AEE L L G G FL+R+ G Y LS+ R H+ I Sbjct: 71 WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCL 130 Query: 65 LNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPC 102 NG I+ L + YS D + C L++PC Sbjct: 131 DNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPC 168 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 30/98 (30%), Positives = 45/98 (45%), Gaps = 6/98 (6%) Query: 163 WYHSSLTREEAERKLYSGAQTDGKFLLR-PRKEQGTYALSLIYGK-----TVYHYLISQD 216 W + L+RE+AE L G FL+R + +G+Y+LS+ + + HY I Sbjct: 71 WLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCL 130 Query: 217 KAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEAC 254 G I F +L LV++ AD + LKE C Sbjct: 131 DNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPC 168 >6CKI-A nrPDB Length = 316 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 38/141 (26%), Positives = 61/141 (43%), Gaps = 14/141 (9%) Query: 412 LVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN 471 LV E GG + + KR + ++ V+ + +L K HRDL N+L + Sbjct: 88 LVFEKMRGGSILSH-IHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEH 146 Query: 472 RHY---AKISDFGLSKALGAD-DSYYTARSAGKWPL---KWYAPECIN-FRK----FSSR 519 + KI DFGL + + D + P ++ APE + F + + R Sbjct: 147 PNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKR 206 Query: 520 SDVWSYGVTMWEALSYGQKPY 540 D+WS GV ++ LS G P+ Sbjct: 207 CDLWSLGVILYILLS-GYPPF 226 >2WO6-A nrPDB Length = 382 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 51/200 (25%), Positives = 83/200 (41%), Gaps = 17/200 (8%) Query: 341 DIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEM-MREAQIMHQLDNP--- 396 D +G G+FG V + R+ ++ VAIK++K + ++ +R ++M++ D Sbjct: 59 DSLIGKGSFGQVVKAYDRVEQEW--VAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKY 116 Query: 397 YIVRLI-GVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE-- 453 YIV L L LV EM + ++ + Q+ + +L Sbjct: 117 YIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATP 176 Query: 454 EKNFVHRDLAARNVLLVN--RHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI 511 E + +H DL N+LL N R KI DFG S LG Y + +PE + Sbjct: 177 ELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRF------YRSPEVL 230 Query: 512 NFRKFSSRSDVWSYGVTMWE 531 + D+WS G + E Sbjct: 231 LGMPYDLAIDMWSLGCILVE 250 >3E3P-A nrPDB Length = 360 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 61/211 (28%), Positives = 90/211 (42%), Gaps = 38/211 (18%) Query: 345 GCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL---DNPYIVRL 401 G G FG+V+ G + + + VAIK + Q D RE QIM L +P IV+L Sbjct: 32 GQGTFGTVQLG--KEKSTGMSVAIKKVIQ-----DPRFRNRELQIMQDLAVLHHPNIVQL 84 Query: 402 IGVCQAEA--------LMLVMEMAGGGPLHKFLVGK-REEI--PVSNVAELLHQV--SMG 448 L +VME LH+ R ++ P + L Q+ S+G Sbjct: 85 QSYFYTLGERDRRDIYLNVVMEYVPDT-LHRCCRNYYRRQVAPPPILIKVFLFQLIRSIG 143 Query: 449 MKYLEEKNFVHRDLAARNVLLVNRH--YAKISDFGLSKALGADD---SYYTARSAGKWPL 503 +L N HRD+ NV LVN K+ DFG +K L + +Y +R Sbjct: 144 CLHLPSVNVCHRDIKPHNV-LVNEADGTLKLCDFGSAKKLSPSEPNVAYICSRY------ 196 Query: 504 KWYAPECI-NFRKFSSRSDVWSYGVTMWEAL 533 + APE I + +++ D+WS G E + Sbjct: 197 -YRAPELIFGNQHYTTAVDIWSVGCIFAEMM 226 >4NT4-A nrPDB Length = 312 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 36/151 (23%), Positives = 68/151 (45%), Gaps = 11/151 (7%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNP-YIVRL 401 ++GCGNFG +R G + + + ++ +K + E + H + P I R+ Sbjct: 19 KIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLEYRFYKLLGSHADNAPDGIPRI 78 Query: 402 --IGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 +G C +V+E+ G F + R + + V + Q+ ++Y+ ++ ++ Sbjct: 79 YHLGTCGGRYNAMVLELLGLSLEDLFNICAR-KFSLKTVLMIAKQLLHRIEYVHSRHLIY 137 Query: 460 RDLAARNVLLVNRHYAK------ISDFGLSK 484 RD+ N L+ R K I DFGL+K Sbjct: 138 RDVKPEN-FLIGRTSTKREKIIHIIDFGLAK 167 >5TE0-A nrPDB Length = 347 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 24/97 (24%), Positives = 46/97 (47%), Gaps = 19/97 (19%) Query: 457 FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK----------WPLKWY 506 +HRDL N+LL +R + + DFG A + + ++ G L + Sbjct: 147 IIHRDLKVENILLHDRGHYVLCDFG-----SATNKFQNPQTEGVNAVEDEIKKYTTLSYR 201 Query: 507 APECINF---RKFSSRSDVWSYGVTMWEALSYGQKPY 540 APE +N + ++++D+W+ G +++ L Y P+ Sbjct: 202 APEMVNLYSGKIITTKADIWALGCLLYK-LCYFTLPF 237 >2QLU-A nrPDB Length = 314 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 39/147 (26%), Positives = 64/147 (43%), Gaps = 31/147 (21%) Query: 410 LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK-----------NFV 458 L L+ G L +L G I + + + +S G+ YL E + Sbjct: 88 LWLITAFHDKGSLTDYLKGNI--ITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIA 145 Query: 459 HRDLAARNVLLVNRHYAKISDFGLS------KALGADDSYYTARSAGKWPLKWYAPEC-- 510 HRD ++NVLL + A ++DFGL+ K G R ++ APE Sbjct: 146 HRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTR-------RYMAPEVLE 198 Query: 511 --INFRKFSS-RSDVWSYGVTMWEALS 534 INF++ + R D+++ G+ +WE +S Sbjct: 199 GAINFQRDAFLRIDMYAMGLVLWELVS 225 >6O6Q-A nrPDB Length = 335 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 46/207 (22%), Positives = 97/207 (46%), Gaps = 27/207 (13%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL-DNPYIVRL 401 +LG G + V G+ ++++ V IKVLK K ++ RE I+ L D P I+ + Sbjct: 48 KLGRGKYSEVFLGIDLEKREK--VVIKVLKPVKRK----KIKREISILKNLVDGPNIIAM 101 Query: 402 IGVC---QAEALMLVMEMAGGGPLHKFLVGKREEIPV---SNVAELLHQVSMGMKYLEEK 455 + V Q++ L+ E + R P ++ ++++ + Y Sbjct: 102 LDVVREPQSKTPGLIFEHINN-------IDFRSLYPTFTDYDIRFYMYELLKALDYSHSM 154 Query: 456 NFVHRDLAARNVLL-VNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPE-CINF 513 +HRD+ NV++ ++ ++ D+GL++ + Y R A ++ + PE +++ Sbjct: 155 GIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHP-GTEYNVRVASRY---FKGPELLVDY 210 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPY 540 R + D+WS+G M ++ + ++P+ Sbjct: 211 RLYDYSLDMWSFG-CMLASMVFMKEPF 236 >2C47-A nrPDB Length = 313 Score = 39.3 bits (90), Expect = 0.005, Method: Compositional matrix adjust. Identities = 36/147 (24%), Positives = 64/147 (43%), Gaps = 9/147 (6%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ++GCGNFG +R G + + + ++ +K + E R + + + V Sbjct: 11 KIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLE--YRFYKQLSATEGVPQVYYF 68 Query: 403 GVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 G C M V+E+ G F + R + V + Q+ M+Y+ K+ ++RD+ Sbjct: 69 GPCGKYNAM-VLELLGPSLEDLFDLCDR-TFTLKTVLMIAIQLITRMEYVHTKSLIYRDV 126 Query: 463 AARNVLL-----VNRHYAKISDFGLSK 484 N L+ +H I DFGL+K Sbjct: 127 KPENFLVGRPGTKRQHAIHIIDFGLAK 153 >5VDK-A nrPDB Length = 297 Score = 39.3 bits (90), Expect = 0.005, Method: Compositional matrix adjust. Identities = 32/139 (23%), Positives = 63/139 (45%), Gaps = 14/139 (10%) Query: 343 ELGCGNFGSVRQGVYRMRK--KQIDVAIKVLKQ-GTEKADTEEMMREAQIMHQLDNPYIV 399 ++G G FG+V + + R+ I ++K + E + E+ A + H P++V Sbjct: 22 KIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHH---PHVV 78 Query: 400 RLIGVCQAEALMLVM-EMAGGGPLHKFLV-----GKREEIPVSNVAELLHQVSMGMKYLE 453 R + M++ E GG L + G E P + ++L Q+S+G+ Y+ Sbjct: 79 RYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEP--KLKDILLQISLGLNYIH 136 Query: 454 EKNFVHRDLAARNVLLVNR 472 + VH D+ N+ + ++ Sbjct: 137 NSSMVHLDIKPSNIFICHK 155 >2CMW-A nrPDB Length = 310 Score = 39.3 bits (90), Expect = 0.005, Method: Compositional matrix adjust. Identities = 37/147 (25%), Positives = 64/147 (43%), Gaps = 8/147 (5%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ++GCGNFG +R G + + + ++ +K + E + Q+ + V Sbjct: 7 KIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYK-QLGSAGEGLPQVYYF 65 Query: 403 GVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 G C M V+E+ G F + R + V + Q+ M+Y+ KN ++RD+ Sbjct: 66 GPCGKYNAM-VLELLGPSLEDLFDLCDR-TFTLKTVLMIAIQLLSRMEYVHSKNLIYRDV 123 Query: 463 AARNVLLVNR-----HYAKISDFGLSK 484 N L+ + H I DFGL+K Sbjct: 124 KPENFLIGRQGNKKEHVIHIIDFGLAK 150 >2CS0-A nrPDB Length = 119 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 25/81 (30%), Positives = 39/81 (48%), Gaps = 3/81 (3%) Query: 163 WYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYC 222 W+H +++RE+AE L S Q G FL+R Y LS + H+++ G + Sbjct: 18 WFHGAISREDAENLLES--QPLGSFLIRVSHSHVGYTLSYKAQSSCCHFMVKLLDDGTFM 75 Query: 223 IP-EGTKFDTLWQLVEYLKLK 242 IP E +L LV + + K Sbjct: 76 IPGEKVAHTSLDALVTFHQQK 96 Score = 36.2 bits (82), Expect = 0.048, Method: Compositional matrix adjust. Identities = 29/83 (34%), Positives = 42/83 (50%), Gaps = 4/83 (4%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69 +F+G+ISR +AE L+ + G FL+R S GY LS HF ++ +GT+ Sbjct: 18 WFHGAISREDAENLLESQPL--GSFLIR-VSHSHVGYTLSYKAQSSCCHFMVKLLDDGTF 74 Query: 70 AIAGGK-AHCGPAELCEFYSRDP 91 I G K AH L F+ + P Sbjct: 75 MIPGEKVAHTSLDALVTFHQQKP 97 >6GVJ-A nrPDB Length = 429 Score = 38.9 bits (89), Expect = 0.007, Method: Compositional matrix adjust. Identities = 55/243 (22%), Positives = 104/243 (42%), Gaps = 39/243 (16%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEM---MREAQIMHQLD--NPY 397 ++G G V Q + KKQI AIK + E+AD + + E +++L + Sbjct: 151 QIGSGGSSKVFQVLNE--KKQI-YAIKYV--NLEEADNQTLDSYRNEIAYLNKLQQHSDK 205 Query: 398 IVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVS------NVAELLHQVSMGMKY 451 I+RL + + ++ G L+ +L K+ P N+ E +H + Sbjct: 206 IIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTI------ 259 Query: 452 LEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI 511 + VH DL N L+V+ K+ DFG++ + D + + + + + PE I Sbjct: 260 -HQHGIVHSDLKPANFLIVDG-MLKLIDFGIANQMQPDTTS-VVKDSQVGTVNYMPPEAI 316 Query: 512 NFRKFSSRS-----------DVWSYGVTMWEALSYGQKPYKKM--KGPEVMAFIEQGKRM 558 S + DVWS G ++ ++YG+ P++++ + ++ A I+ + Sbjct: 317 KDMSSSRENGKSKSKISPKSDVWSLGCILY-YMTYGKTPFQQIINQISKLHAIIDPNHEI 375 Query: 559 ECP 561 E P Sbjct: 376 EFP 378 >6FYV-A nrPDB Length = 337 Score = 38.5 bits (88), Expect = 0.008, Method: Compositional matrix adjust. Identities = 30/139 (21%), Positives = 55/139 (39%), Gaps = 26/139 (18%) Query: 435 VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYA------------------- 475 + ++ ++ +Q+ + +L H DL N+L V Y Sbjct: 117 IDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDI 176 Query: 476 KISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSY 535 K+ DFG + DD +++ + + + APE I +S DVWS G + E Sbjct: 177 KVVDFG---SATYDDEHHSTLVSTR---HYRAPEVILALGWSQPCDVWSIGCILIEYY-L 229 Query: 536 GQKPYKKMKGPEVMAFIEQ 554 G ++ E +A +E+ Sbjct: 230 GFTVFQTHDSKEHLAMMER 248 >3HMP-A nrPDB Length = 342 Score = 38.1 bits (87), Expect = 0.010, Method: Compositional matrix adjust. Identities = 60/258 (23%), Positives = 111/258 (43%), Gaps = 41/258 (15%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEM---MREAQIMHQLD--NPY 397 ++G G V Q + KKQI AIK + E+AD + + E +++L + Sbjct: 63 QIGSGGSSKVFQVLNE--KKQI-YAIKYV--NLEEADNQTLDSYRNEIAYLNKLQQHSDK 117 Query: 398 IVRLIGV-CQAEALMLVMEMAGGGPLHKFLVGKREEIPVS------NVAELLHQVSMGMK 450 I+RL + + +VME G L+ +L K+ P N+ E +H + Sbjct: 118 IIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTI----- 171 Query: 451 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510 + VH DL N L+V+ K+ DFG++ + D + + + + + PE Sbjct: 172 --HQHGIVHSDLKPANFLIVDG-MLKLIDFGIANQMQPDTTS-VVKDSQVGTVNYMPPEA 227 Query: 511 INFRKFSSRS-----------DVWSYGVTMWEALSYGQKPYKKM--KGPEVMAFIEQGKR 557 I S + DVWS G ++ ++YG+ P++++ + ++ A I+ Sbjct: 228 IKDMSSSRENGKSKSKISPKSDVWSLGCILY-YMTYGKTPFQQIINQISKLHAIIDPNHE 286 Query: 558 MECPPECPPELYALMSDC 575 +E P +L ++ C Sbjct: 287 IEFPDIPEKDLQDVLKCC 304 >2X7G-A nrPDB Length = 389 Score = 38.1 bits (87), Expect = 0.012, Method: Compositional matrix adjust. Identities = 38/143 (26%), Positives = 68/143 (47%), Gaps = 22/143 (15%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG---TEKADTE----EMMREAQ------- 388 +LG G+F +V + M+ K+ VA+KV+K TE A E + +RE+ Sbjct: 38 KLGWGHFSTVWL-CWDMQGKRF-VAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKD 95 Query: 389 -IMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSM 447 ++ +D+ I + G+ + +V E+ G L + + +PV V ++ QV Sbjct: 96 MVVQLIDDFKISGMNGI----HVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQ 151 Query: 448 GMKYLEEK-NFVHRDLAARNVLL 469 G+ YL K +H D+ N+L+ Sbjct: 152 GLDYLHSKCKIIHTDIKPENILM 174 >6CMQ-A nrPDB Length = 427 Score = 37.7 bits (86), Expect = 0.014, Method: Compositional matrix adjust. Identities = 35/116 (30%), Positives = 56/116 (48%), Gaps = 18/116 (15%) Query: 163 WYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYG----------KTVYHY 211 W+H L+ +EAE KL + G FL+R + G + LS+ G V H Sbjct: 10 WFHGHLSGKEAE-KLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHV 68 Query: 212 LISQDKAGKYCIPEGTKFDTLWQLVEYLK----LKADGLIYCLKEACPNSSASNAS 263 +I + KY + G +FD+L LVE+ K ++ G + LK+ N++ NA+ Sbjct: 69 MIRCQEL-KYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPL-NTTRINAA 122 >2ZMD-A nrPDB Length = 390 Score = 37.7 bits (86), Expect = 0.016, Method: Compositional matrix adjust. Identities = 60/258 (23%), Positives = 111/258 (43%), Gaps = 41/258 (15%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEM---MREAQIMHQLD--NPY 397 ++G G V Q + KKQI AIK + E+AD + + E +++L + Sbjct: 63 QIGSGGSSKVFQVLNE--KKQI-YAIKYV--NLEEADNQTLDSYRNEIAYLNKLQQHSDK 117 Query: 398 IVRLIGV-CQAEALMLVMEMAGGGPLHKFLVGKREEIPVS------NVAELLHQVSMGMK 450 I+RL + + +VME G L+ +L K+ P N+ E +H + Sbjct: 118 IIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTI----- 171 Query: 451 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510 + VH DL N L+V+ K+ DFG++ + D + + + + + PE Sbjct: 172 --HQHGIVHSDLKPANFLIVDG-MLKLIDFGIANQMQPDTTS-VVKDSQVGAVNYMPPEA 227 Query: 511 INFRKFSSRS-----------DVWSYGVTMWEALSYGQKPYKKM--KGPEVMAFIEQGKR 557 I S + DVWS G ++ ++YG+ P++++ + ++ A I+ Sbjct: 228 IKDMSSSRENGKSKSKISPKSDVWSLGCILY-YMTYGKTPFQQIINQISKLHAIIDPNHE 286 Query: 558 MECPPECPPELYALMSDC 575 +E P +L ++ C Sbjct: 287 IEFPDIPEKDLQDVLKCC 304 >3EB0-A nrPDB Length = 383 Score = 37.4 bits (85), Expect = 0.018, Method: Compositional matrix adjust. Identities = 33/149 (22%), Positives = 71/149 (47%), Gaps = 16/149 (10%) Query: 393 LDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFL---VGKREEIPVSNVAELLHQVSMGM 449 ++N + ++ Q + L ++ME LHK L + IP++ ++ ++Q+ + Sbjct: 96 VNNHHKSVIVNPSQNKYLNVIMEYVPDT-LHKVLKSFIRSGRSIPMNLISIYIYQLFRAV 154 Query: 450 KYLEEKNFVHRDLAARNVLLVNR-HYAKISDFGLSKALGADD---SYYTARSAGKWPLKW 505 ++ HRD+ +N+L+ ++ + K+ DFG +K L + +Y +R + Sbjct: 155 GFIHSLGICHRDIKPQNLLVNSKDNTLKLCDFGSAKKLIPSEPSVAYICSRF-------Y 207 Query: 506 YAPEC-INFRKFSSRSDVWSYGVTMWEAL 533 APE + +++ D+WS G E + Sbjct: 208 RAPELMLGATEYTPSIDLWSIGCVFGELI 236 >2KK6-A nrPDB Length = 116 Score = 37.4 bits (85), Expect = 0.019, Method: Composition-based stats. Identities = 23/59 (38%), Positives = 33/59 (55%), Gaps = 4/59 (6%) Query: 4 PAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIE 62 P A +++G+I R EA+E LK G FL+R+ G YVLS+ D + HF I+ Sbjct: 13 PLAEQDWYHGAIPRIEAQELLK----KQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQ 67 Score = 33.5 bits (75), Expect = 0.30, Method: Composition-based stats. Identities = 24/78 (30%), Positives = 39/78 (50%), Gaps = 9/78 (11%) Query: 163 WYHSSLTREEAERKLYSGAQTDGKFLLR-PRKEQGTYALSLIYGKTVYHYLISQ-DKAGK 220 WYH ++ R EA+ L + G FL+R + G Y LS+ H++I D + Sbjct: 19 WYHGAIPRIEAQELL----KKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYR 74 Query: 221 YCIPEGTKFDTLWQLVEY 238 + EGT F + QL+++ Sbjct: 75 F---EGTGFSNIPQLIDH 89 >1KA6-A nrPDB Length = 128 Score = 37.4 bits (85), Expect = 0.020, Method: Compositional matrix adjust. Identities = 21/59 (35%), Positives = 31/59 (52%), Gaps = 2/59 (3%) Query: 164 YHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYHYLISQDKAGKY 221 YH ++RE E KL DG +LLR + G Y L ++Y +Y Y +SQ + G + Sbjct: 7 YHGKISRETGE-KLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSW 64 >1M27-A nrPDB Length = 104 Score = 37.0 bits (84), Expect = 0.023, Method: Compositional matrix adjust. Identities = 21/59 (35%), Positives = 31/59 (52%), Gaps = 2/59 (3%) Query: 164 YHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYHYLISQDKAGKY 221 YH ++RE E KL DG +LLR + G Y L ++Y +Y Y +SQ + G + Sbjct: 7 YHGKISRETGE-KLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSW 64 >4XHL-A nrPDB Length = 394 Score = 37.0 bits (84), Expect = 0.024, Method: Compositional matrix adjust. Identities = 56/264 (21%), Positives = 111/264 (42%), Gaps = 29/264 (10%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ++G G+FG + G + +++ + ++ ++ + D E + + + P+I R Sbjct: 14 KIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYRY-LSGGVGIPFI-RWF 71 Query: 403 GVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 G + E +V+++ G F R V L Q+ ++Y+ ++F+HRD+ Sbjct: 72 GR-EGEYNAMVIDLLGPSLEDLFNYCHRR-FSFKTVIMLALQMFCRIQYIHGRSFIHRDI 129 Query: 463 AARNVLL-VNRHYAKIS--DFGLSKALGADDSY----YTARSAGKWPLKWYAPECINFRK 515 N L+ V R + + DFGLSK +++ Y + ++ + + Sbjct: 130 KPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTHLGIE 189 Query: 516 FSSRSDVWSYGVTM---------WEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPEC-- 564 S R D+ S G + W+ L + KK K +M E+ + C Sbjct: 190 QSRRDDLESLGYVLIYFCKGSLPWQGL---KATTKKQKYDRIM---EKKLNVSVETLCSG 243 Query: 565 -PPELYALMSDCWIYKWEDRPDFL 587 P E M+ C K++++PD+L Sbjct: 244 LPLEFQEYMAYCKNLKFDEKPDYL 267 >5AP3-A nrPDB Length = 313 Score = 37.0 bits (84), Expect = 0.024, Method: Compositional matrix adjust. Identities = 60/258 (23%), Positives = 111/258 (43%), Gaps = 41/258 (15%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEM---MREAQIMHQLD--NPY 397 ++G G V Q + KKQI AIK + E+AD + + E +++L + Sbjct: 35 QIGSGGSSKVFQVLNE--KKQI-YAIKYV--NLEEADNQTLDSYRNEIAYLNKLQQHSDK 89 Query: 398 IVRLIGV-CQAEALMLVMEMAGGGPLHKFLVGKREEIPVS------NVAELLHQVSMGMK 450 I+RL + + +VME G L+ +L K+ P N+ E +H + Sbjct: 90 IIRLYDYEITDQYIYMVME-CGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHTI----- 143 Query: 451 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510 + VH DL N L+V+ K+ DFG++ + D + + + + + PE Sbjct: 144 --HQHGIVHSDLKPANFLIVDG-MLKLIDFGIANQMQPDTTS-VVKDSQVGTVNYMPPEA 199 Query: 511 INFRKFSSRS-----------DVWSYGVTMWEALSYGQKPYKKM--KGPEVMAFIEQGKR 557 I S + DVWS G ++ ++YG+ P++++ + ++ A I+ Sbjct: 200 IKDMSSSRENGKSKSKISPKSDVWSLGCILY-YMTYGKTPFQQIINQISKLHAIIDPNHE 258 Query: 558 MECPPECPPELYALMSDC 575 +E P +L ++ C Sbjct: 259 IEFPDIPEKDLQDVLKCC 276 >4XHH-A nrPDB Length = 403 Score = 37.0 bits (84), Expect = 0.027, Method: Compositional matrix adjust. Identities = 55/259 (21%), Positives = 112/259 (43%), Gaps = 19/259 (7%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ++G G+FG + G + +++ + ++ ++ + D E + + + + P+I R Sbjct: 14 KIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYKY-LSGGVGIPFI-RWF 71 Query: 403 GVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 G + E +V+++ G F R+ V L Q+ ++Y+ ++F+HRD+ Sbjct: 72 GR-EGEYNAMVIDLLGPSLEDLFNYCHRK-FSFKTVIMLALQMICRVQYIHGRSFIHRDI 129 Query: 463 AARNVLL-VNRHYAKIS--DFGLSKALGADDSY----YTARSAGKWPLKWYAPECINFRK 515 N L+ V R + + DFGLSK +++ Y + ++ + + Sbjct: 130 KPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTHLGIE 189 Query: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMKGP----EVMAFIEQGKRMECPPEC---PPEL 568 S R D+ S G M G P++ +K + +E+ + C P E Sbjct: 190 QSRRDDLESLGY-MLIYFCKGSLPWQGLKATTKKQKYDRILEKKLCISVETLCAGLPLEF 248 Query: 569 YALMSDCWIYKWEDRPDFL 587 M+ C K+++RPD+L Sbjct: 249 SEYMNYCRNLKFDERPDYL 267 >2EYZ-A nrPDB Length = 304 Score = 37.0 bits (84), Expect = 0.027, Method: Compositional matrix adjust. Identities = 20/52 (38%), Positives = 30/52 (57%), Gaps = 2/52 (3%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPI 61 +++G +SR EA L+ G G+FL+R S G YVLS+ + R H+ I Sbjct: 13 WYWGRLSRQEAVALLQ--GQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYII 62 Score = 34.3 bits (77), Expect = 0.16, Method: Compositional matrix adjust. Identities = 22/59 (37%), Positives = 29/59 (49%), Gaps = 3/59 (5%) Query: 157 AHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYHYLIS 214 + ER WY L+R+EA L Q G FL+R G Y LS+ V HY+I+ Sbjct: 7 SEERSSWYWGRLSRQEAVALLQ--GQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIIN 63 >5VC6-A nrPDB Length = 289 Score = 36.6 bits (83), Expect = 0.033, Method: Compositional matrix adjust. Identities = 35/136 (25%), Positives = 59/136 (43%), Gaps = 14/136 (10%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE----KADTEEMMREAQIMHQL-DNPY 397 ++G G FGSV + V K++D I +K+ + D + +RE L + + Sbjct: 18 KIGSGEFGSVFKCV-----KRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSH 72 Query: 398 IVRLIGVCQAEALMLVM-EMAGGGPLHKFLVGKREEIPVSNVAEL---LHQVSMGMKYLE 453 +VR + ML+ E GG L + + AEL L QV G++Y+ Sbjct: 73 VVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIH 132 Query: 454 EKNFVHRDLAARNVLL 469 + VH D+ N+ + Sbjct: 133 SMSLVHMDIKPSNIFI 148 >5M6U-B nrPDB Length = 724 Score = 36.2 bits (82), Expect = 0.042, Method: Compositional matrix adjust. Identities = 21/62 (33%), Positives = 31/62 (50%), Gaps = 2/62 (3%) Query: 158 HERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDK 217 H+ W S R +AE L + DG FL+R +QG YA S++ V H +I++ Sbjct: 619 HDEKTWNVGSSNRNKAENLL--RGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTA 676 Query: 218 AG 219 G Sbjct: 677 TG 678 Score = 34.7 bits (78), Expect = 0.11, Method: Compositional matrix adjust. Identities = 25/85 (29%), Positives = 39/85 (45%), Gaps = 15/85 (17%) Query: 163 WYHSSLTREEAERKLYSGAQTDGKFLLR--PRKEQGTYALSLIYGKT-----VYHYLISQ 215 WY ++REE KL A DG FL+R K G Y L+L G ++H Sbjct: 333 WYWGDISREEVNEKLRDTA--DGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFH----- 385 Query: 216 DKAGKYCIPEGTKFDTLWQLVEYLK 240 + GKY + F ++ +L+ + + Sbjct: 386 -RDGKYGFSDPLTFSSVVELINHYR 409 Score = 32.3 bits (72), Expect = 0.68, Method: Compositional matrix adjust. Identities = 18/42 (42%), Positives = 24/42 (57%), Gaps = 3/42 (7%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSL-GGYVLSL 50 +++G ISR E E KL ADG FL+R + G Y L+L Sbjct: 333 WYWGDISREEVNE--KLRDTADGTFLVRDASTKMHGDYTLTL 372 >5X8I-B nrPDB Length = 346 Score = 36.2 bits (82), Expect = 0.044, Method: Compositional matrix adjust. Identities = 26/116 (22%), Positives = 46/116 (39%), Gaps = 25/116 (21%) Query: 435 VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYA------------------- 475 + ++ ++ +Q+ + +L H DL N+L V Y Sbjct: 116 LDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDI 175 Query: 476 KISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWE 531 K+ DFG + DD +++ + + + APE I +S DVWS G + E Sbjct: 176 KVVDFG---SATYDDEHHSTLVSTR---HYRAPEVILALGWSQPCDVWSIGCILIE 225 >2CHL-A nrPDB Length = 351 Score = 36.2 bits (82), Expect = 0.049, Method: Compositional matrix adjust. Identities = 37/150 (24%), Positives = 64/150 (42%), Gaps = 15/150 (10%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL---DNPYIV 399 ++GCGNFG +R G + + + ++ + K+ ++ E + QL D V Sbjct: 37 KIGCGNFGELRLGKNLYTNEYVAIKLEPM-----KSRAPQLHLEYRFYKQLGSGDGIPQV 91 Query: 400 RLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 G C M V+E+ G F + R + V + Q+ M+Y+ KN ++ Sbjct: 92 YYFGPCGKYNAM-VLELLGPSLEDLFDLCDR-TFSLKTVLMIAIQLISRMEYVHSKNLIY 149 Query: 460 RDLAARNVLL-----VNRHYAKISDFGLSK 484 RD+ N L+ + I DF L+K Sbjct: 150 RDVKPENFLIGRPGNKTQQVIHIIDFALAK 179 >5ZTN-A nrPDB Length = 429 Score = 35.8 bits (81), Expect = 0.061, Method: Compositional matrix adjust. Identities = 50/207 (24%), Positives = 83/207 (40%), Gaps = 33/207 (15%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLK-------QGTEKADTEEMMREA------QIM 390 +G G+FG V + Y + Q VA+K+++ Q E+ E +R+ ++ Sbjct: 105 IGKGSFGQVVKA-YDHKVHQ-HVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVI 162 Query: 391 HQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMK 450 H L+N I + M + E+ F +P+ V + H + + Sbjct: 163 HMLENFTFRNHICMTFELLSMNLYELIKKNKFQGF------SLPL--VRKFAHSILQCLD 214 Query: 451 YLEEKNFVHRDLAARNVLLVN--RHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY-A 507 L + +H DL N+LL R K+ DFG S Y R ++Y A Sbjct: 215 ALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSS-------CYEHQRVYTYIQSRFYRA 267 Query: 508 PECINFRKFSSRSDVWSYGVTMWEALS 534 PE I ++ D+WS G + E L+ Sbjct: 268 PEVILGARYGMPIDMWSLGCILAELLT 294 >5M07-A nrPDB Length = 276 Score = 35.4 bits (80), Expect = 0.065, Method: Compositional matrix adjust. Identities = 27/126 (21%), Positives = 58/126 (46%), Gaps = 8/126 (6%) Query: 367 AIKVLKQGTEKADT--EEMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLH 423 A+KVL D RE ++ +L +P+I+ + + + L + M+ G Sbjct: 59 ALKVLSPAMAADDEFRRRFQRETEVAARLFHPHILEVHDRGEFDGQLWIAMDYVDGIDAT 118 Query: 424 KFLVGKREEI-PVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAK----IS 478 + + + + PV V ++ V+ + Y ++ +HRD+ NV+L ++ ++ Sbjct: 119 QHMADRFPAVLPVGEVLAIVTAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLA 178 Query: 479 DFGLSK 484 DFG++ Sbjct: 179 DFGIAS 184 >5IKW-A nrPDB Length = 310 Score = 35.4 bits (80), Expect = 0.068, Method: Compositional matrix adjust. Identities = 25/92 (27%), Positives = 44/92 (47%), Gaps = 9/92 (9%) Query: 457 FVHRDLAARNVLLVNRHYAKISDFG--LSKALG--ADDSYYTARSAGKW-PLKWYAPECI 511 +HRDL N+LL + + DFG +K L D K+ L + APE I Sbjct: 141 IIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMI 200 Query: 512 NF---RKFSSRSDVWSYGVTMWEALSYGQKPY 540 N + ++++D+W+ G +++ L + P+ Sbjct: 201 NLYGGKPITTKADIWALGCLLYK-LCFFTLPF 231 >2HDV-A nrPDB Length = 111 Score = 35.0 bits (79), Expect = 0.10, Method: Composition-based stats. Identities = 21/82 (25%), Positives = 43/82 (52%), Gaps = 3/82 (3%) Query: 162 PWYHSSLTR-EEAERKLYSGAQTDGKFLLRPRK-EQGTYALSLIYGKTVYHYLISQDKAG 219 PW+H L+R + A+ L G + G FL+R + +G L+ + H +S + AG Sbjct: 10 PWFHGMLSRLKAAQLVLEGGTGSHGVFLVRQSETRRGECVLTFNFQGKAKHLRLSLNAAG 69 Query: 220 KYCIPEGTKFDTLWQLVEYLKL 241 + C + F +++ ++E+ ++ Sbjct: 70 Q-CRVQHLHFQSIFDMLEHFRV 90 >6J6I-B nrPDB Length = 351 Score = 34.7 bits (78), Expect = 0.11, Method: Compositional matrix adjust. Identities = 47/209 (22%), Positives = 90/209 (43%), Gaps = 34/209 (16%) Query: 347 GNFGS---VRQGVY-RMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL-------DN 395 NF S V Q VY + + +I+ ++K+ +E T + R ++ + + ++ Sbjct: 58 NNFDSSCFVSQDVYYKWYRGEIEDRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNH 117 Query: 396 PYIVRLIGVCQAEAL-MLVMEMAGGGPLHK----FLVGKREEIPVSNVAELLHQVSMGMK 450 ++L+G C +LV E A G +++ + G+ +P S ++ +++ + Sbjct: 118 SNFLQLLGCCLEFPFPVLVFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVT 177 Query: 451 YLEE---KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLK--- 504 YL K +HRD+ +V L AK+SD S +L S R +W L Sbjct: 178 YLHTAFPKIIIHRDVKPMHVFLDKNWTAKLSDLSFSISLPEGKS----RIEAEWVLGTFG 233 Query: 505 ----WYAPECINFRKFSSRSDVWSYGVTM 529 Y C + +DV+S+G+ + Sbjct: 234 YIDPLYHKTCF----VTEYTDVYSFGICL 258 >6EWX-A nrPDB Length = 484 Score = 34.7 bits (78), Expect = 0.12, Method: Compositional matrix adjust. Identities = 15/34 (44%), Positives = 23/34 (67%) Query: 438 VAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN 471 V LL Q+ G+++L+E +HRDL N+LLV+ Sbjct: 212 VCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVH 245 >4Y12-A nrPDB Length = 375 Score = 34.7 bits (78), Expect = 0.14, Method: Compositional matrix adjust. Identities = 36/170 (21%), Positives = 68/170 (40%), Gaps = 18/170 (10%) Query: 366 VAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAE------ALMLVMEMAGG 419 V +K L + M E Q + ++ +P IV++ + +VME GG Sbjct: 148 VVLKGLVHSGDAEAQAMAMAERQFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGG 207 Query: 420 GPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISD 479 L + K +++PV+ L ++ + YL V+ DL N++L K+ D Sbjct: 208 QSLKR---SKGQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEEQL-KLID 263 Query: 480 FGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTM 529 G + + Y + APE + + +D+++ G T+ Sbjct: 264 LGAVSRINSFGYLYGTPG-------FQAPEIVRTGP-TVATDIYTVGRTL 305 >5VE6-A nrPDB Length = 492 Score = 34.7 bits (78), Expect = 0.14, Method: Compositional matrix adjust. Identities = 15/34 (44%), Positives = 23/34 (67%) Query: 438 VAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN 471 V LL Q+ G+++L+E +HRDL N+LLV+ Sbjct: 210 VCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVH 243 >4LFI-A nrPDB Length = 374 Score = 34.3 bits (77), Expect = 0.15, Method: Compositional matrix adjust. Identities = 22/95 (23%), Positives = 51/95 (53%), Gaps = 7/95 (7%) Query: 448 GMKYLEEKNFVHRDLAARNVLLVNRHYA-KISDFGLSKALGADDSYYTARSAGKWPLKWY 506 + Y +HRD+ NV++ +++ ++ D+GL++ + Y R A ++ + Sbjct: 184 ALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME-YNVRVASRF---FK 239 Query: 507 APE-CINFRKFSSRSDVWSYGVTMWEALSYGQKPY 540 PE +++R + D+WS+G TM ++ + ++P+ Sbjct: 240 GPELLVDYRMYDYSLDLWSFG-TMLASMIFKREPF 273 >2PZI-A nrPDB Length = 681 Score = 34.3 bits (77), Expect = 0.16, Method: Compositional matrix adjust. Identities = 29/122 (23%), Positives = 51/122 (41%), Gaps = 10/122 (8%) Query: 366 VAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAE------ALMLVMEMAGG 419 V +K L + M E Q + ++ +P IV++ + +VME GG Sbjct: 109 VVLKGLVHSGDAEAQAMAMAERQFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGG 168 Query: 420 GPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISD 479 L + K +++PV+ L ++ + YL V+ DL N++L K+ D Sbjct: 169 QSLKR---SKGQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEEQL-KLID 224 Query: 480 FG 481 G Sbjct: 225 LG 226 >1MIL-A nrPDB Length = 104 Score = 33.5 bits (75), Expect = 0.25, Method: Composition-based stats. Identities = 18/41 (43%), Positives = 27/41 (65%), Gaps = 4/41 (9%) Query: 9 PFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLS 49 P+F+G +SR EAE L+L +G FL+R+ + G YVL+ Sbjct: 8 PWFHGKLSRREAEALLQL----NGDFLVRESTTTPGQYVLT 44 Score = 33.5 bits (75), Expect = 0.28, Method: Composition-based stats. Identities = 29/103 (28%), Positives = 45/103 (43%), Gaps = 24/103 (23%) Query: 162 PWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYHYLISQDKAGK 220 PW+H L+R EAE L Q +G FL+R G Y L+ + H L+ Sbjct: 8 PWFHGKLSRREAEALL----QLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVD----- 58 Query: 221 YCIPEGT------KFDTLWQLVEY-----LKLKADGLIYCLKE 252 PEG +F+++ L+ Y L + + G CL++ Sbjct: 59 ---PEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQ 98 >4AZW-A nrPDB Length = 471 Score = 33.1 bits (74), Expect = 0.32, Method: Compositional matrix adjust. Identities = 33/121 (27%), Positives = 55/121 (45%), Gaps = 10/121 (8%) Query: 365 DVAIKVLKQGTEKADTEEMMREAQIMHQ----LDNPYIVRLIGVCQAEALMLVMEMAGGG 420 D+ +L + + E+ E + + Q D P + L A++ LVME G Sbjct: 270 DMPHGILTAEESQRNKHELHNEIKFLTQPPAGFDAPAV--LAHGENAQSGWLVMEKLPGR 327 Query: 421 PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDF 480 L L EEI + ++L + + LE+K F H D+ NV++ R +A++ DF Sbjct: 328 LLSDMLAAG-EEI---DREKILGSLLRSLAALEKKGFWHDDVRPWNVMVDARQHARLIDF 383 Query: 481 G 481 G Sbjct: 384 G 384 >5CLR-A nrPDB Length = 451 Score = 32.7 bits (73), Expect = 0.50, Method: Compositional matrix adjust. Identities = 39/171 (22%), Positives = 67/171 (39%), Gaps = 32/171 (18%) Query: 443 HQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWP 502 HQV K E +HRDL N++L + DF G+ S + A Sbjct: 187 HQV----KQFHELGLIHRDLKPGNIMLDADMQCHLVDF------GSSSSDKEPKPASWGT 236 Query: 503 LKWYAPECI---NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRME 559 + APE +F FS SD+++ ++ E + P++++K +V I+ + Sbjct: 237 ASYLAPELNAQEDFIAFSQVSDLFALAYSLDELFN----PFRQVKFAKVDIGIKNKHLVL 292 Query: 560 CPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGS 610 E + LMS+ E +R Y+S +++ P S Sbjct: 293 LHAEIEACITGLMSN---------------ETSVRTLYFSRILQLQRVPES 328 >1XA6-A nrPDB Length = 466 Score = 32.7 bits (73), Expect = 0.54, Method: Compositional matrix adjust. Identities = 17/40 (42%), Positives = 25/40 (62%), Gaps = 3/40 (7%) Query: 11 FYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSL 50 F+G ISR +A+E L G +G ++LR+ R G Y L+L Sbjct: 58 FHGIISREQADE---LLGGVEGAYILRESQRQPGCYTLAL 94 >5UV4-A nrPDB Length = 311 Score = 32.3 bits (72), Expect = 0.55, Method: Compositional matrix adjust. Identities = 43/180 (23%), Positives = 84/180 (46%), Gaps = 14/180 (7%) Query: 366 VAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC---QAEALMLVMEMAGGGPL 422 + +K LK+G K+ +E RE + + + +P +V L G + +++ + A L Sbjct: 52 LTVKWLKEGFAKS-KKEFSREIKKLGSVRHPNLVPLRGYYWGPKEHERIMISDYADATSL 110 Query: 423 HKFL--VGKREEIPVSNVAELLHQVSMG--MKYLEEKNFV-HRDLAARNVLLVNRH-YAK 476 +L +R P+S L + + + YL + + H ++ + NVL+ N A Sbjct: 111 STYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHNERVIPHGNIKSSNVLIQNSTPSAL 170 Query: 477 ISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKF--SSRSDVWSYGVTMWEALS 534 ++D+ L + + +AG L + PE + K S +SDV+++GV + E L+ Sbjct: 171 VTDYSLHRLMTPIGMAEQVLNAGA--LGYSPPEFSSTSKPCPSLKSDVYAFGVILLELLT 228 >4MD7-E nrPDB Length = 391 Score = 32.0 bits (71), Expect = 0.74, Method: Compositional matrix adjust. Identities = 21/101 (20%), Positives = 51/101 (50%), Gaps = 7/101 (6%) Query: 442 LHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYA-KISDFGLSKALGADDSYYTARSAGK 500 ++++ + Y +HRD+ NV++ + H ++ D+GL++ Y R A + Sbjct: 137 MYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-YNVRVASR 195 Query: 501 WPLKWYAPE-CINFRKFSSRSDVWSYGVTMWEALSYGQKPY 540 + + PE ++++ + D+WS G M ++ + ++P+ Sbjct: 196 Y---FKGPELLVDYQMYDYSLDMWSLG-CMLASMIFRKEPF 232 >4AZV-A nrPDB Length = 569 Score = 32.0 bits (71), Expect = 0.81, Method: Compositional matrix adjust. Identities = 24/75 (32%), Positives = 39/75 (52%), Gaps = 4/75 (5%) Query: 407 AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARN 466 A++ LVME G L L EEI + ++L + + LE++ F H D+ N Sbjct: 314 AQSGWLVMEKLPGRLLSDMLAAG-EEI---DREKILGSLLRSLAALEKQGFWHDDVRPWN 369 Query: 467 VLLVNRHYAKISDFG 481 V++ R +A++ DFG Sbjct: 370 VMVDARQHARLIDFG 384 >3QWY-A nrPDB Length = 308 Score = 32.0 bits (71), Expect = 0.86, Method: Compositional matrix adjust. Identities = 19/56 (33%), Positives = 29/56 (51%), Gaps = 3/56 (5%) Query: 163 WYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSL---IYGKTVYHYLISQ 215 +Y ++REEA + L + G FL+R G Y+L++ G V HYLI + Sbjct: 43 FYFPGMSREEAHKLLGEPQVSIGTFLMRDSSRPGEYSLTVREADEGNAVCHYLIER 98 >3ZUS-A nrPDB Length = 927 Score = 31.6 bits (70), Expect = 1.1, Method: Compositional matrix adjust. Identities = 23/75 (30%), Positives = 39/75 (52%), Gaps = 4/75 (5%) Query: 164 YHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYH--YLISQDKAGKY 221 + SL E Y+ + L + + GT A SL Y K V+ YL+S+D +GK+ Sbjct: 274 FIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTA-SLQYMKNVFKEKYLLSEDTSGKF 332 Query: 222 CIPEGTKFDTLWQLV 236 + + KFD L++++ Sbjct: 333 SV-DKLKFDKLYKML 346 >3ZUR-A nrPDB Length = 960 Score = 31.2 bits (69), Expect = 1.3, Method: Compositional matrix adjust. Identities = 23/75 (30%), Positives = 39/75 (52%), Gaps = 4/75 (5%) Query: 164 YHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYH--YLISQDKAGKY 221 + SL E Y+ + L + + GT A SL Y K V+ YL+S+D +GK+ Sbjct: 276 FIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTA-SLQYMKNVFKEKYLLSEDTSGKF 334 Query: 222 CIPEGTKFDTLWQLV 236 + + KFD L++++ Sbjct: 335 SV-DKLKFDKLYKML 348 >3R11-A nrPDB Length = 379 Score = 30.8 bits (68), Expect = 1.7, Method: Compositional matrix adjust. Identities = 22/90 (24%), Positives = 40/90 (44%), Gaps = 9/90 (10%) Query: 308 MPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVA 367 M +D + Y + +++ KL + N ++ D+ + CGN Q + + A Sbjct: 103 MAIDLA-YHDLLAKEQDISVAKLLGAKANSIVTDVSISCGNVAETIQNIQNGVEANF-TA 160 Query: 368 IKVLKQGTEKADTEEMMREAQIMHQLDNPY 397 IKV K G + R+ Q++ LDN + Sbjct: 161 IKV-KTGA------DFNRDIQLLKALDNEF 183 >5XVU-A nrPDB Length = 332 Score = 30.8 bits (68), Expect = 1.8, Method: Compositional matrix adjust. Identities = 24/107 (22%), Positives = 51/107 (47%), Gaps = 9/107 (8%) Query: 437 NVAELLHQVSMGMKYLEEKNFVHRDLAARNVLL--VNRHYAKISDFGLSKALGADDSYYT 494 ++ ++Q+ + Y + +HRD+ N+++ NR IS +GL++ Y Sbjct: 126 DIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLIS-WGLAEFYHPGQE-YN 183 Query: 495 ARSAGKWPLKWYAPE-CINFRKFSSRSDVWSYGVTMWEALSYGQKPY 540 R A ++ + PE I+ + + D+WS G M + + ++P+ Sbjct: 184 VRVASRY---YKGPELLIDLQLYDYSLDIWSLG-CMLAGMIFKKEPF 226 >5OAT-A nrPDB Length = 411 Score = 30.8 bits (68), Expect = 2.1, Method: Compositional matrix adjust. Identities = 36/144 (25%), Positives = 58/144 (40%), Gaps = 23/144 (15%) Query: 448 GMKYLEEKNFVHRDLAARNVLLVNRH----YAKISDFGL-----SKALGADDSYYTARSA 498 G+ ++ HRDL + N+LL ISDFG + L + Y Sbjct: 165 GVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKG 224 Query: 499 GKWPLKWYAPECI-----NFRKFS-SRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI 552 G L APE I F + S++D+W+ G +E + Y GP + Sbjct: 225 GNTAL--MAPEIICQKPGTFSVLNYSKADLWAVGAIAYEIFNCHNPFY----GPSRLKNF 278 Query: 553 --EQGKRMECPPECPPELYALMSD 574 ++G + P E P + AL+++ Sbjct: 279 NYKEGDLPKLPDEVPTVIQALVAN 302 >3K3Q-C nrPDB Length = 175 Score = 30.8 bits (68), Expect = 2.1, Method: Composition-based stats. Identities = 23/72 (31%), Positives = 38/72 (52%), Gaps = 4/72 (5%) Query: 167 SLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYH--YLISQDKAGKYCIP 224 SL E Y+ + L + + GT A SL Y K V+ YL+S+D +GK+ + Sbjct: 26 SLQENEFRLYYYNKFKDIASTLNKAKSIVGTTA-SLQYMKNVFKEKYLLSEDTSGKFSV- 83 Query: 225 EGTKFDTLWQLV 236 + KFD L++++ Sbjct: 84 DKLKFDKLYKML 95 >2W2D-A nrPDB Length = 450 Score = 30.4 bits (67), Expect = 2.1, Method: Compositional matrix adjust. Identities = 23/75 (30%), Positives = 39/75 (52%), Gaps = 4/75 (5%) Query: 164 YHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYH--YLISQDKAGKY 221 + SL E Y+ + L + + GT A SL Y K V+ YL+S+D +GK+ Sbjct: 277 FIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTA-SLQYMKNVFKEKYLLSEDTSGKF 335 Query: 222 CIPEGTKFDTLWQLV 236 + + KFD L++++ Sbjct: 336 SV-DKLKFDKLYKML 349 >6EII-A nrPDB Length = 352 Score = 30.4 bits (67), Expect = 2.2, Method: Compositional matrix adjust. Identities = 21/101 (20%), Positives = 51/101 (50%), Gaps = 7/101 (6%) Query: 442 LHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYA-KISDFGLSKALGADDSYYTARSAGK 500 ++++ + Y +HRD+ NV++ + H ++ D+GL++ Y R A + Sbjct: 160 MYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE-YNVRVASR 218 Query: 501 WPLKWYAPE-CINFRKFSSRSDVWSYGVTMWEALSYGQKPY 540 + + PE ++++ + D+WS G M ++ + ++P+ Sbjct: 219 Y---FKGPELLVDYQMYDYSLDMWSLG-CMLASMIFRKEPF 255 >5WQK-A nrPDB Length = 293 Score = 30.4 bits (67), Expect = 2.2, Method: Compositional matrix adjust. Identities = 24/83 (28%), Positives = 37/83 (44%), Gaps = 9/83 (10%) Query: 5 AAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQC---LRSLGGYVLSLVHDVRFHHFPI 61 A H + GS+ + A + G GL+ + R+ G + +SL+ D F H+ Sbjct: 75 ATHFADYAGSLGVSAATHVVIYDGSDQGLYSAPRVWWMFRAFGHHSVSLL-DGGFRHW-- 131 Query: 62 ERQLNGTYAIAGGKAHCGPAELC 84 LN I+ GK+H PAE Sbjct: 132 ---LNQNLPISSGKSHSEPAEFS 151 >1E1H-B nrPDB Length = 174 Score = 30.4 bits (67), Expect = 2.5, Method: Composition-based stats. Identities = 23/72 (31%), Positives = 38/72 (52%), Gaps = 4/72 (5%) Query: 167 SLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYH--YLISQDKAGKYCIP 224 SL E Y+ + L + + GT A SL Y K V+ YL+S+D +GK+ + Sbjct: 26 SLQENEFRLYYYNKFKDVASTLNKAKSIIGTTA-SLQYMKNVFKEKYLLSEDTSGKFSV- 83 Query: 225 EGTKFDTLWQLV 236 + KFD L++++ Sbjct: 84 DKLKFDKLYKML 95 >2VIF-A nrPDB Length = 141 Score = 30.4 bits (67), Expect = 2.5, Method: Composition-based stats. Identities = 37/131 (28%), Positives = 58/131 (44%), Gaps = 19/131 (14%) Query: 163 WYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIY---GKTVYHYLI-SQDKA 218 WY +TR EAE KL + DG FL+R + Y LSL + GKT++ + S + Sbjct: 26 WYWGPITRWEAEGKLAN--VPDGSFLVRDSSDD-RYLLSLSFRSHGKTLHTRIEHSNGRF 82 Query: 219 GKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLT 278 Y P+ ++ L+E+ ++ +C S S G+A +P LT Sbjct: 83 SFYEQPDVEGHTSIVDLIEHSIGDSENGAFCY-------SRSRLPGSA-----TYPVRLT 130 Query: 279 HPQRRIDTLNS 289 +P R + S Sbjct: 131 NPVSRFMQVRS 141 >5X1R-A nrPDB Length = 302 Score = 30.0 bits (66), Expect = 2.8, Method: Compositional matrix adjust. Identities = 20/127 (15%), Positives = 58/127 (45%), Gaps = 2/127 (1%) Query: 360 RKKQIDVAIKVLKQG-TEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLV-MEMA 417 R + + ++ + G T +A ++EA+++ + +P ++ ++ + + + Sbjct: 62 RNDDLSIGLRGERFGKTFQAGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFY 121 Query: 418 GGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKI 477 G L + E+I + + LL + + + ++ ++HRD++ N+ + + Sbjct: 122 SGTTLKNLQAQQPEKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVL 181 Query: 478 SDFGLSK 484 DFG ++ Sbjct: 182 LDFGSAR 188 >1RPY-A nrPDB Length = 114 Score = 30.0 bits (66), Expect = 2.8, Method: Composition-based stats. Identities = 22/61 (36%), Positives = 34/61 (55%), Gaps = 5/61 (8%) Query: 9 PFFYGSISRAEAEEHLKLAG--MADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLN 66 P+F+G++SR +A + L LAG + GLF++RQ G VL+ + H + LN Sbjct: 12 PWFHGTLSRVKAAQ-LVLAGGPRSHGLFVIRQSETRPGECVLTFNFQGKAKHLRL--SLN 68 Query: 67 G 67 G Sbjct: 69 G 69 >5UU1-A nrPDB Length = 324 Score = 29.6 bits (65), Expect = 3.8, Method: Compositional matrix adjust. Identities = 24/75 (32%), Positives = 39/75 (52%), Gaps = 4/75 (5%) Query: 411 MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLL- 469 +VME G L K + G+ S V +L ++ ++Y+ E +VH D+ A N+LL Sbjct: 107 FMVMERLGI-DLQK-ISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLG 164 Query: 470 -VNRHYAKISDFGLS 483 N ++D+GLS Sbjct: 165 YKNPDQVYLADYGLS 179 >6HMD-A nrPDB Length = 365 Score = 29.6 bits (65), Expect = 4.0, Method: Compositional matrix adjust. Identities = 21/101 (20%), Positives = 52/101 (51%), Gaps = 7/101 (6%) Query: 442 LHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYA-KISDFGLSKALGADDSYYTARSAGK 500 ++++ + Y K +HRD+ NV++ ++ ++ D+GL++ Y R A + Sbjct: 153 MYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE-YNVRVASR 211 Query: 501 WPLKWYAPE-CINFRKFSSRSDVWSYGVTMWEALSYGQKPY 540 + + PE ++++ + D+WS G M ++ + ++P+ Sbjct: 212 Y---FKGPELLVDYQMYDYSLDMWSLG-CMLASMIFRREPF 248 >3CXL-A nrPDB Length = 463 Score = 29.6 bits (65), Expect = 4.2, Method: Compositional matrix adjust. Identities = 16/40 (40%), Positives = 25/40 (62%), Gaps = 3/40 (7%) Query: 11 FYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSL 50 F+G ISR A++ L +A+G +L+R+ R G Y L+L Sbjct: 54 FHGMISREAADQ---LLIVAEGSYLIRESQRQPGTYTLAL 90 >6GSK-4I nrPDB Length = 126 Score = 28.9 bits (63), Expect = 6.1, Method: Composition-based stats. Identities = 15/33 (45%), Positives = 19/33 (57%), Gaps = 2/33 (6%) Query: 106 SGLEPQPGVFDCLRDAMVR--DYVRQTWKLEGE 136 +G+ P V D +VR +YV TWKLEGE Sbjct: 37 TGINPATRVKDLTEAEVVRLREYVENTWKLEGE 69 >3K4E-A nrPDB Length = 369 Score = 28.9 bits (63), Expect = 7.4, Method: Compositional matrix adjust. Identities = 22/81 (27%), Positives = 36/81 (44%), Gaps = 12/81 (14%) Query: 149 VEKLIATTAHERMPWYHSSLTRE------------EAERKLYSGAQTDGKFLLRPRKEQG 196 ++K I T E++P+ SSLT +R L G+ D + +L K+ Sbjct: 154 IQKAIETIPIEKLPFILSSLTGHIYHLSTHSYGCRVIQRLLEFGSSEDQESILNELKDFI 213 Query: 197 TYALSLIYGKTVYHYLISQDK 217 Y + YG V Y++ QD+ Sbjct: 214 PYLIQDQYGNYVIQYVLQQDQ 234 >2RSV-A nrPDB Length = 403 Score = 28.5 bits (62), Expect = 8.2, Method: Compositional matrix adjust. Identities = 18/67 (26%), Positives = 31/67 (46%), Gaps = 2/67 (2%) Query: 419 GGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLL--VNRHYAK 476 G L K + V +L ++ ++Y+ E +VH D+ A N+LL N Sbjct: 142 GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVY 201 Query: 477 ISDFGLS 483 + D+GL+ Sbjct: 202 LVDYGLA 208 >1CSN-A nrPDB Length = 298 Score = 28.5 bits (62), Expect = 8.3, Method: Compositional matrix adjust. Identities = 36/147 (24%), Positives = 63/147 (42%), Gaps = 11/147 (7%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G G+FG + +G + +Q VAIK + ++ + R +++ V G Sbjct: 18 IGEGSFGVIFEGTNLLNNQQ--VAIKFEPRRSDAPQLRDEYRTYKLLAGCTGIPNVYYFG 75 Query: 404 VCQAEALMLVMEMAGGGP-LHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 E L V+ + GP L L + V VA Q+ ++ + EK+ V+RD+ Sbjct: 76 ---QEGLHNVLVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHEKSLVYRDI 132 Query: 463 AARNVLL-----VNRHYAKISDFGLSK 484 N L+ N + + DFG+ K Sbjct: 133 KPDNFLIGRPNSKNANMIYVVDFGMVK 159 >2LAV-A nrPDB Length = 361 Score = 28.5 bits (62), Expect = 8.7, Method: Compositional matrix adjust. Identities = 18/67 (26%), Positives = 31/67 (46%), Gaps = 2/67 (2%) Query: 419 GGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLL--VNRHYAK 476 G L K + V +L ++ ++Y+ E +VH D+ A N+LL N Sbjct: 135 GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVY 194 Query: 477 ISDFGLS 483 + D+GL+ Sbjct: 195 LVDYGLA 201 >3LLT-A nrPDB Length = 360 Score = 28.5 bits (62), Expect = 9.7, Method: Compositional matrix adjust. Identities = 46/240 (19%), Positives = 91/240 (37%), Gaps = 22/240 (9%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDV-AIKVLKQGTEKADTE-EMMREAQIMHQ 392 +N + ++G G FG V + KK V ++ +K+ T A E +++++ Q Sbjct: 34 NNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKKIQNDDI 93 Query: 393 LDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYL 452 +N + + + L+ E G + ++ ++ + YL Sbjct: 94 NNNNIVKYHGKFMYYDHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYL 153 Query: 453 EEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKW------- 505 + + H DL N+LL + ++ K G Y +S G + + Sbjct: 154 RKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATFKS 213 Query: 506 -YAPECINFRKFSS-----------RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIE 553 Y IN R++ + SD+WS+G + E L G ++ + E +A +E Sbjct: 214 DYHGSIINTRQYRAPEVILNLGWDVSSDMWSFGCVLAE-LYTGSLLFRTHEHMEHLAMME 272 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2OZO-A nrPDB 891 0.0 4FL3-A nrPDB 739 0.0 4XEY-B nrPDB 424 e-119 2FO0-A nrPDB 422 e-118 1U59-A nrPDB 408 e-114 2H8H-A nrPDB 400 e-112 6F3F-A nrPDB 399 e-111 4XZ1-A nrPDB 395 e-110 1AD5-A nrPDB 392 e-109 1K9A-A nrPDB 371 e-103 1A81-A nrPDB 369 e-102 4XI2-A nrPDB 369 e-102 5C26-A nrPDB 341 4e-94 4CSV-A nrPDB 334 6e-92 4P5Q-A nrPDB 333 1e-91 5MJB-A nrPDB 326 2e-89 1JPA-A nrPDB 323 2e-88 6NPU-A nrPDB 320 1e-87 5L6P-A nrPDB 320 1e-87 3DKO-A nrPDB 318 4e-87 2Y6O-A nrPDB 318 5e-87 2PL0-A nrPDB 317 9e-87 2R2P-A nrPDB 315 3e-86 2XYN-A nrPDB 315 5e-86 5SYS-A nrPDB 312 2e-85 4PDO-A nrPDB 312 2e-85 2VWV-A nrPDB 311 5e-85 2HK5-A nrPDB 311 8e-85 2DQ7-X nrPDB 310 1e-84 3KUL-B nrPDB 309 3e-84 5A46-A nrPDB 308 3e-84 4EBW-A nrPDB 308 3e-84 2PSQ-A nrPDB 307 1e-83 2J0K-A nrPDB 306 1e-83 3A4O-X nrPDB 306 3e-83 3TT0-A nrPDB 305 3e-83 4E93-A nrPDB 302 2e-82 5EG3-A nrPDB 302 3e-82 3GQL-A nrPDB 301 5e-82 4H1J-A nrPDB 300 9e-82 4XCU-A nrPDB 299 2e-81 6GQK-A nrPDB 299 3e-81 5AMN-A nrPDB 298 5e-81 4K33-A nrPDB 293 1e-79 4OLI-A nrPDB 293 2e-79 3BBT-B nrPDB 292 3e-79 5FM2-A nrPDB 291 6e-79 4HZS-A nrPDB 291 7e-79 4AT3-A nrPDB 290 1e-78 3CJF-A nrPDB 289 2e-78 1U54-B nrPDB 289 3e-78 2OGV-A nrPDB 289 3e-78 3BEA-A nrPDB 288 5e-78 3KRL-A nrPDB 286 1e-77 3V5Q-A nrPDB 286 1e-77 3I81-A nrPDB 286 2e-77 5KMM-A nrPDB 286 2e-77 3PP0-A nrPDB 284 6e-77 3ZBF-A nrPDB 284 6e-77 5H2U-A nrPDB 284 7e-77 5GNK-A nrPDB 284 8e-77 4R7H-A nrPDB 284 8e-77 3G0E-A nrPDB 284 8e-77 3LZB-A nrPDB 283 2e-76 5X02-A nrPDB 282 3e-76 1FVR-A nrPDB 282 3e-76 3QGY-A nrPDB 282 3e-76 1BYG-A nrPDB 282 4e-76 5U6B-A nrPDB 281 5e-76 5HLW-A nrPDB 281 5e-76 3C1X-A nrPDB 281 5e-76 4XUF-A nrPDB 281 5e-76 1LUF-A nrPDB 280 1e-75 3SXS-A nrPDB 280 1e-75 5GRN-A nrPDB 279 2e-75 4XLV-A nrPDB 279 2e-75 6DBM-A nrPDB 279 3e-75 6E4F-A nrPDB 278 4e-75 4Y93-A nrPDB 278 4e-75 4E20-A nrPDB 278 7e-75 5U6C-A nrPDB 276 1e-74 4LRM-A nrPDB 276 2e-74 3QUP-A nrPDB 275 5e-74 6DBN-A nrPDB 274 8e-74 2W1I-A nrPDB 272 3e-73 3IO7-A nrPDB 271 6e-73 6FEX-A nrPDB 270 1e-72 3PLS-A nrPDB 270 1e-72 3AOX-A nrPDB 268 4e-72 6BSD-A nrPDB 266 2e-71 5WNO-A nrPDB 266 3e-71 6FER-A nrPDB 265 3e-71 4HVI-A nrPDB 263 2e-70 3ZZW-A nrPDB 263 2e-70 3PPZ-A nrPDB 262 3e-70 4UY9-A nrPDB 259 2e-69 3DTC-A nrPDB 259 3e-69 4UYA-A nrPDB 257 1e-68 4GS6-A nrPDB 256 3e-68 3LMG-A nrPDB 253 1e-67 4MVF-A nrPDB 253 2e-67 5X5O-A nrPDB 252 3e-67 2QNJ-A nrPDB 251 8e-67 5ES1-A nrPDB 250 1e-66 5KZ7-A nrPDB 250 2e-66 5EZV-A nrPDB 249 2e-66 3HZT-A nrPDB 248 4e-66 3NCG-A nrPDB 248 4e-66 5JN2-A nrPDB 248 4e-66 5IG1-A nrPDB 247 7e-66 3Q5I-A nrPDB 247 1e-65 3DFA-A nrPDB 247 1e-65 3DXN-A nrPDB 246 2e-65 3MA6-A nrPDB 246 2e-65 4CFF-A nrPDB 246 3e-65 3UTO-A nrPDB 245 5e-65 6FDY-U nrPDB 244 7e-65 5HI2-A nrPDB 244 1e-64 2BDW-A nrPDB 243 1e-64 3KK8-A nrPDB 242 3e-64 3MN3-A nrPDB 241 5e-64 5D9K-A nrPDB 241 9e-64 3LIJ-A nrPDB 240 1e-63 3OMV-A nrPDB 240 1e-63 4CFH-A nrPDB 240 1e-63 2HAK-A nrPDB 240 1e-63 4QMW-A nrPDB 240 2e-63 2YZA-A nrPDB 240 2e-63 5HVK-A nrPDB 240 2e-63 5FG8-A nrPDB 240 2e-63 3H4J-B nrPDB 239 2e-63 4REW-A nrPDB 239 2e-63 4RED-A nrPDB 239 2e-63 5HIE-A nrPDB 239 3e-63 4FG9-A nrPDB 239 3e-63 2V7O-A nrPDB 239 3e-63 5VO2-A nrPDB 239 3e-63 2Z7Q-A nrPDB 238 4e-63 4D28-A nrPDB 238 5e-63 6C9D-A nrPDB 237 8e-63 5XZW-A nrPDB 237 9e-63 3COM-A nrPDB 237 1e-62 2VN9-A nrPDB 236 2e-62 4WNO-A nrPDB 236 2e-62 2XIK-A nrPDB 236 3e-62 5YKS-A nrPDB 235 5e-62 4FZF-B nrPDB 234 6e-62 4CZT-A nrPDB 234 6e-62 2JC6-A nrPDB 234 6e-62 6QAU-A nrPDB 233 1e-61 3BHH-A nrPDB 233 2e-61 4RGJ-A nrPDB 232 3e-61 6FD3-A nrPDB 232 4e-61 3IS5-A nrPDB 232 4e-61 2WQN-A nrPDB 232 4e-61 4CQG-A nrPDB 232 4e-61 4NEU-A nrPDB 231 5e-61 5U6Y-A nrPDB 231 6e-61 4RA4-A nrPDB 231 7e-61 5DYK-A nrPDB 231 9e-61 1FOT-A nrPDB 231 9e-61 2JDO-A nrPDB 231 1e-60 2VZ6-A nrPDB 230 1e-60 4D2V-A nrPDB 230 1e-60 3HDN-A nrPDB 229 3e-60 5F9E-A nrPDB 229 3e-60 5FET-A nrPDB 229 4e-60 3Q53-A nrPDB 228 5e-60 4LG4-A nrPDB 228 5e-60 5KCV-A nrPDB 228 7e-60 4YNZ-A nrPDB 227 7e-60 3SOA-A nrPDB 227 1e-59 3MV5-A nrPDB 226 2e-59 4L42-A nrPDB 226 2e-59 6AO5-A nrPDB 226 2e-59 4YZB-A nrPDB 226 2e-59 2JAM-A nrPDB 226 2e-59 4YFF-A nrPDB 225 4e-59 4RLP-A nrPDB 225 5e-59 4PDS-A nrPDB 225 6e-59 4F0G-A nrPDB 225 6e-59 4UZD-A nrPDB 224 7e-59 4APC-A nrPDB 224 8e-59 3KN6-A nrPDB 224 8e-59 3DAK-A nrPDB 224 1e-58 3TXO-A nrPDB 224 1e-58 2UV2-A nrPDB 223 1e-58 2Y7J-A nrPDB 223 2e-58 1KOA-A nrPDB 222 3e-58 6E9W-A nrPDB 222 3e-58 4B6L-A nrPDB 222 3e-58 3TKU-A nrPDB 222 4e-58 3DB8-A nrPDB 222 4e-58 4JXF-A nrPDB 221 5e-58 2W4O-A nrPDB 221 6e-58 4I6B-A nrPDB 221 7e-58 4TPT-A nrPDB 221 7e-58 2YCR-A nrPDB 220 1e-57 5DBX-A nrPDB 220 2e-57 2XNP-A nrPDB 219 2e-57 6CMJ-A nrPDB 219 4e-57 2I0E-A nrPDB 218 5e-57 2F57-A nrPDB 218 5e-57 2BPM-A nrPDB 218 6e-57 4BBM-A nrPDB 218 6e-57 3F3Z-A nrPDB 218 6e-57 5X3F-B nrPDB 218 6e-57 3D2K-A nrPDB 218 6e-57 3PFQ-A nrPDB 218 7e-57 5JZN-A nrPDB 217 8e-57 3I6U-A nrPDB 217 9e-57 3TAC-A nrPDB 217 1e-56 4WB7-A nrPDB 217 1e-56 4AW2-A nrPDB 217 1e-56 3GUB-A nrPDB 217 1e-56 2OU7-A nrPDB 217 1e-56 6BDL-A nrPDB 217 2e-56 5N23-A nrPDB 216 2e-56 4J52-A nrPDB 216 2e-56 6E2O-A nrPDB 216 2e-56 6HXF-B nrPDB 216 3e-56 4AGU-A nrPDB 216 3e-56 4NIF-A nrPDB 216 3e-56 2J90-A nrPDB 215 4e-56 4FIE-A nrPDB 215 5e-56 3NIZ-A nrPDB 215 5e-56 4KRC-A nrPDB 215 6e-56 6ED6-A nrPDB 214 7e-56 5TOS-A nrPDB 214 9e-56 4XBR-A nrPDB 213 1e-55 3UC3-A nrPDB 213 2e-55 2Q0N-A nrPDB 213 2e-55 5YV8-A nrPDB 213 2e-55 4KS7-A nrPDB 213 2e-55 4JDH-A nrPDB 212 3e-55 5WAX-A nrPDB 211 6e-55 5D7A-A nrPDB 211 7e-55 2X4F-A nrPDB 211 7e-55 5UIU-A nrPDB 211 9e-55 6GU6-A nrPDB 210 1e-54 1PHK-A nrPDB 210 2e-54 5WNL-A nrPDB 210 2e-54 1VZO-A nrPDB 209 3e-54 2YAB-A nrPDB 209 4e-54 4JG6-A nrPDB 208 5e-54 3ZDU-A nrPDB 208 5e-54 4AU8-A nrPDB 208 6e-54 1KOB-A nrPDB 207 9e-54 3ZUT-A nrPDB 207 9e-54 3NYO-A nrPDB 207 1e-53 3A8W-A nrPDB 207 1e-53 6BXI-A nrPDB 206 2e-53 1G3N-A nrPDB 206 2e-53 5NGU-A nrPDB 206 3e-53 1U5R-A nrPDB 206 3e-53 3UDB-A nrPDB 206 3e-53 2VD5-A nrPDB 206 3e-53 4QTB-A nrPDB 205 4e-53 1ZWS-A nrPDB 205 4e-53 2A27-A nrPDB 205 5e-53 1NY3-A nrPDB 205 5e-53 5LOH-A nrPDB 205 5e-53 2GCD-A nrPDB 205 5e-53 3ORZ-A nrPDB 205 5e-53 1UA2-A nrPDB 205 6e-53 2OZA-A nrPDB 204 8e-53 3C51-A nrPDB 204 8e-53 3KA0-A nrPDB 204 9e-53 6CQF-A nrPDB 204 1e-52 4C0T-A nrPDB 202 3e-52 5J5T-A nrPDB 202 3e-52 5EFQ-A nrPDB 202 3e-52 4B8L-A nrPDB 202 3e-52 3HNG-A nrPDB 202 3e-52 4EWQ-A nrPDB 202 3e-52 4AN9-A nrPDB 202 4e-52 2BRG-A nrPDB 201 6e-52 5Z33-A nrPDB 201 6e-52 3VN9-A nrPDB 201 7e-52 3VHK-A nrPDB 201 8e-52 3FME-A nrPDB 201 8e-52 4BGQ-A nrPDB 201 8e-52 1CM8-A nrPDB 201 1e-51 5G6V-A nrPDB 201 1e-51 4FR4-A nrPDB 200 1e-51 6CTH-A nrPDB 200 2e-51 3FXW-A nrPDB 200 2e-51 6J5U-C nrPDB 200 2e-51 3ORP-A nrPDB 199 2e-51 1V0B-A nrPDB 199 3e-51 3HKO-A nrPDB 199 4e-51 4NST-A nrPDB 199 4e-51 4AF3-A nrPDB 199 4e-51 4TNB-A nrPDB 198 5e-51 4MYG-A nrPDB 198 6e-51 2W96-B nrPDB 197 1e-50 4YHJ-A nrPDB 197 1e-50 3OHT-A nrPDB 197 2e-50 3ALO-A nrPDB 197 2e-50 5LPZ-A nrPDB 196 3e-50 5O2B-A nrPDB 196 3e-50 6CCF-A nrPDB 195 3e-50 4IC8-A nrPDB 195 3e-50 4U41-A nrPDB 195 3e-50 5LPV-A nrPDB 195 4e-50 3LM0-A nrPDB 195 4e-50 4ZSG-A nrPDB 195 5e-50 6DTL-A nrPDB 195 5e-50 4M7I-A nrPDB 195 5e-50 2A1A-B nrPDB 194 7e-50 5O2C-A nrPDB 194 7e-50 4PWN-A nrPDB 194 8e-50 2WTK-C nrPDB 194 1e-49 4QNY-A nrPDB 194 1e-49 5AWM-A nrPDB 194 1e-49 2XS0-A nrPDB 194 1e-49 5AR8-A nrPDB 193 2e-49 3QA8-A nrPDB 193 2e-49 3OZ6-A nrPDB 193 2e-49 3FI2-A nrPDB 192 3e-49 1JNK-A nrPDB 192 3e-49 4EQM-A nrPDB 192 4e-49 4OTD-A nrPDB 192 5e-49 5O0Y-A nrPDB 191 6e-49 3UIU-A nrPDB 191 7e-49 3MIA-A nrPDB 190 1e-48 5UUU-A nrPDB 190 1e-48 5B2L-A nrPDB 190 1e-48 3GC9-A nrPDB 190 1e-48 5USZ-A nrPDB 190 1e-48 4KIK-B nrPDB 190 2e-48 3PVW-A nrPDB 190 2e-48 2HW6-A nrPDB 190 2e-48 4BTF-A nrPDB 189 2e-48 3GC0-A nrPDB 189 3e-48 4M69-B nrPDB 189 3e-48 2Y4I-B nrPDB 189 3e-48 3E7O-A nrPDB 189 3e-48 4CRS-A nrPDB 189 4e-48 4M66-A nrPDB 187 9e-48 5KKR-C nrPDB 187 1e-47 2F9G-A nrPDB 187 1e-47 1ZXE-A nrPDB 186 2e-47 5XD6-A nrPDB 186 2e-47 3EQC-A nrPDB 185 3e-47 4PL5-B nrPDB 185 5e-47 3DLS-A nrPDB 184 8e-47 3UIM-A nrPDB 184 1e-46 5TQX-A nrPDB 183 2e-46 1S9I-A nrPDB 183 2e-46 4RT7-A nrPDB 183 2e-46 2QKW-B nrPDB 183 2e-46 2I6L-A nrPDB 182 4e-46 3N9X-A nrPDB 182 5e-46 4IDT-A nrPDB 181 8e-46 3NIE-A nrPDB 181 9e-46 4X7Q-B nrPDB 181 9e-46 2BUJ-A nrPDB 179 2e-45 4MWI-A nrPDB 179 3e-45 3RP9-A nrPDB 179 3e-45 4O2Z-A nrPDB 179 5e-45 1TKI-A nrPDB 178 5e-45 4OW8-A nrPDB 178 5e-45 4X3F-A nrPDB 178 5e-45 3M42-A nrPDB 178 5e-45 6B2Q-A nrPDB 178 6e-45 3Q4U-A nrPDB 178 8e-45 3BGP-A nrPDB 177 9e-45 1PY5-A nrPDB 177 1e-44 3MDY-A nrPDB 177 1e-44 4RC3-A nrPDB 177 2e-44 3PG1-A nrPDB 177 2e-44 5AIR-A nrPDB 176 2e-44 5TUR-A nrPDB 176 3e-44 3REP-A nrPDB 175 5e-44 6BFN-A nrPDB 175 5e-44 4LQP-A nrPDB 175 5e-44 2RIO-A nrPDB 174 8e-44 6HV0-A nrPDB 174 1e-43 4E7W-A nrPDB 174 2e-43 4L00-A nrPDB 173 2e-43 3MY0-A nrPDB 172 4e-43 4G3E-A nrPDB 172 6e-43 5Y86-A nrPDB 172 6e-43 3QD2-B nrPDB 171 8e-43 4C59-A nrPDB 169 4e-42 4JLC-A nrPDB 168 6e-42 4H1O-A nrPDB 167 1e-41 4EUU-A nrPDB 167 1e-41 4EUT-A nrPDB 166 3e-41 4TN6-A nrPDB 165 5e-41 4Y83-A nrPDB 165 6e-41 6NT9-A nrPDB 164 8e-41 6O8B-A nrPDB 164 1e-40 4CRL-A nrPDB 163 2e-40 5C01-A nrPDB 162 3e-40 4WOV-A nrPDB 162 5e-40 5E8V-A nrPDB 160 1e-39 5FQD-C nrPDB 160 1e-39 5VD3-A nrPDB 159 3e-39 2H34-A nrPDB 159 4e-39 3G2F-A nrPDB 159 5e-39 3SV0-A nrPDB 158 9e-39 2WTK-B nrPDB 152 3e-37 5J0A-A nrPDB 151 8e-37 3SOC-A nrPDB 148 8e-36 4IAN-A nrPDB 144 9e-35 3RAW-A nrPDB 144 1e-34 5UNP-A nrPDB 143 1e-34 6AMW-A nrPDB 139 3e-33 3T04-A nrPDB 138 9e-33 2LQW-A nrPDB 137 1e-32 2PMN-X nrPDB 131 8e-31 2ABL-A nrPDB 131 1e-30 2AUG-A nrPDB 129 3e-30 5L2Q-C nrPDB 128 6e-30 5U06-A nrPDB 127 1e-29 1NRV-A nrPDB 126 3e-29 2EKX-A nrPDB 115 7e-26 2CRH-A nrPDB 114 1e-25 2LCT-A nrPDB 113 3e-25 2EOB-A nrPDB 107 2e-23 2PLE-A nrPDB 102 5e-22 1GRI-A nrPDB 99 5e-21 Sequences not found previously or not previously below threshold: 6CKI-A nrPDB 179 3e-45 6GVJ-A nrPDB 170 2e-42 3HMP-A nrPDB 168 5e-42 5AP3-A nrPDB 167 1e-41 2ZMD-A nrPDB 167 2e-41 2WO6-A nrPDB 161 9e-40 5ZTN-A nrPDB 160 2e-39 5TE0-A nrPDB 157 2e-38 5IKW-A nrPDB 157 2e-38 3E3P-A nrPDB 155 5e-38 3EB0-A nrPDB 154 9e-38 6FYV-A nrPDB 152 3e-37 5X8I-B nrPDB 152 5e-37 6O6Q-A nrPDB 144 1e-34 5VDK-A nrPDB 143 2e-34 5VC6-A nrPDB 142 4e-34 2QLU-A nrPDB 142 6e-34 4XHH-A nrPDB 135 6e-32 2B3O-A nrPDB 133 2e-31 3PS5-A nrPDB 132 4e-31 3LLT-A nrPDB 130 1e-30 4XHL-A nrPDB 127 1e-29 4MD7-E nrPDB 127 1e-29 4BTK-A nrPDB 127 2e-29 2CMW-A nrPDB 126 3e-29 4NFN-A nrPDB 126 3e-29 5X18-A nrPDB 126 4e-29 5XVU-A nrPDB 125 4e-29 4L68-A nrPDB 125 4e-29 6EII-A nrPDB 125 4e-29 2PVN-A nrPDB 125 4e-29 4NT4-A nrPDB 123 2e-28 4WUA-A nrPDB 123 3e-28 2JD5-A nrPDB 123 3e-28 6HMD-A nrPDB 122 5e-28 2X7G-A nrPDB 122 5e-28 2C47-A nrPDB 122 6e-28 2CHL-A nrPDB 120 1e-27 4F9B-A nrPDB 120 2e-27 4I94-A nrPDB 120 3e-27 1CSN-A nrPDB 118 5e-27 6J6I-B nrPDB 118 1e-26 4LFI-A nrPDB 115 4e-26 5X1R-A nrPDB 115 8e-26 5OAT-A nrPDB 111 8e-25 6DC0-A nrPDB 111 1e-24 5CEK-A nrPDB 110 2e-24 5M07-A nrPDB 109 5e-24 2PZI-A nrPDB 108 7e-24 4Y12-A nrPDB 107 1e-23 6EQI-C nrPDB 103 2e-22 5UV4-A nrPDB 103 2e-22 4M4Z-A nrPDB 95 7e-20 4JRN-A nrPDB 89 5e-18 6CMQ-A nrPDB 87 2e-17 2EYZ-A nrPDB 84 1e-16 6EAS-A nrPDB 84 1e-16 5CLR-A nrPDB 81 1e-15 5UU1-A nrPDB 79 7e-15 5GZ9-A nrPDB 78 1e-14 5M6U-B nrPDB 78 2e-14 2RSV-A nrPDB 77 3e-14 2LAV-A nrPDB 77 3e-14 4IX6-A nrPDB 76 4e-14 5GZA-A nrPDB 72 6e-13 2JII-A nrPDB 69 5e-12 2KK6-A nrPDB 69 6e-12 1KA6-A nrPDB 68 1e-11 4O1O-A nrPDB 67 2e-11 2CS0-A nrPDB 67 2e-11 1M27-A nrPDB 66 4e-11 5DMZ-A nrPDB 66 5e-11 1MIL-A nrPDB 65 7e-11 4OAU-C nrPDB 65 8e-11 6G4J-A nrPDB 65 1e-10 6EWX-A nrPDB 64 2e-10 >2OZO-A nrPDB Length = 613 Score = 891 bits (2303), Expect = 0.0, Method: Composition-based stats. Identities = 603/606 (99%), Positives = 606/606 (100%) Query: 1 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP 60 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP Sbjct: 1 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP 60 Query: 61 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD 120 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD Sbjct: 61 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD 120 Query: 121 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG 180 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG Sbjct: 121 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG 180 Query: 181 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK 240 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK Sbjct: 181 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK 240 Query: 241 LKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARIT 300 LKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARIT Sbjct: 241 LKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARIT 300 Query: 301 SPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMR 360 SPDKPRPMPMDTSV+ESP+SDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMR Sbjct: 301 SPDKPRPMPMDTSVFESPFSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMR 360 Query: 361 KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGG 420 KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGG Sbjct: 361 KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGG 420 Query: 421 PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDF 480 PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR+LAARNVLLVNRHYAKISDF Sbjct: 421 PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRNLAARNVLLVNRHYAKISDF 480 Query: 481 GLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY 540 GLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY Sbjct: 481 GLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY 540 Query: 541 KKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL 600 KKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL Sbjct: 541 KKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL 600 Query: 601 ASKVEG 606 ASKVEG Sbjct: 601 ASKVEG 606 >4FL3-A nrPDB Length = 635 Score = 739 bits (1909), Expect = 0.0, Method: Composition-based stats. Identities = 340/631 (53%), Positives = 450/631 (71%), Gaps = 30/631 (4%) Query: 1 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP 60 M D A HLPFF+G+I+R EAE++L GM+DGL+LLRQ LGG+ LS+ H + HH+ Sbjct: 6 MADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYT 65 Query: 61 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD 120 IER+LNGTYAIAGG+ H PA+LC ++S++ DGL C L+KP NRP G++P+ G F+ L++ Sbjct: 66 IERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKE 125 Query: 121 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG 180 ++R+YV+QTW L+G+ALEQAIISQ PQ+EKLIATTAHE+MPW+H ++REE+E+ + G Sbjct: 126 NLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIG 185 Query: 181 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK 240 ++T+GKFL+R R G+YAL L++ V HY I +DK GK IPEG KFDTLWQLVE+ Sbjct: 186 SKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYS 245 Query: 241 LKADGLIYCLKEACPN-SSASNASGAAAPTLP-AHPSTLT-------------------- 278 KADGL+ L C + N + P LP +HP+T + Sbjct: 246 YKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRK 305 Query: 279 ----HPQRRIDTLNSDGYTPEPARITSPDKPR--PMPMDTSVYESPYSDPEELKDKKLFL 332 R+ T++ + Y PE A + P+ +PMDT V+ESP++DPEE++ K+++L Sbjct: 306 SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVFESPFADPEEIRPKEVYL 365 Query: 333 KRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QGTEKADTEEMMREAQIMH 391 R L + D ELG GNFG+V++G Y+M+K VA+K+LK + + A +E++ EA +M Sbjct: 366 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 425 Query: 392 QLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKY 451 QLDNPYIVR+IG+C+AE+ MLVMEMA GPL+K+L R N+ EL+HQVSMGMKY Sbjct: 426 QLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKD-KNIIELVHQVSMGMKY 484 Query: 452 LEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI 511 LEE NFVHRDLAARNVLLV +HYAKISDFGLSKAL AD++YY A++ GKWP+KWYAPECI Sbjct: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544 Query: 512 NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYAL 571 N+ KFSS+SDVWS+GV MWEA SYGQKPY+ MKG EV A +E+G+RM CP CP E+Y L Sbjct: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDL 604 Query: 572 MSDCWIYKWEDRPDFLTVEQRMRACYYSLAS 602 M+ CW Y E+RP F VE R+R YY + + Sbjct: 605 MNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 >4XEY-B nrPDB Length = 408 Score = 424 bits (1089), Expect = e-119, Method: Composition-based stats. Identities = 149/469 (31%), Positives = 229/469 (48%), Gaps = 72/469 (15%) Query: 152 LIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSLIYGKTVYH 210 + + + E+ WYH ++R AE L SG +G FL+R + G ++SL Y VYH Sbjct: 1 MASVNSLEKHSWYHGPVSRNAAEYLLSSG--INGSFLVRESESSPGQRSISLRYEGRVYH 58 Query: 211 YLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTL 270 Y I+ GK + ++F+TL +LV + ADGLI L P Sbjct: 59 YRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAP--------------- 103 Query: 271 PAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKL 330 + +P SP D E++ + Sbjct: 104 --------------------------------KRNKPTVYGV----SPNYDKWEMERTDI 127 Query: 331 FLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIM 390 +K +LG G +G V +GV++ K + VA+K LK+ T + EE ++EA +M Sbjct: 128 TMKH--------KLGGGQYGEVYEGVWK--KYSLTVAVKTLKEDT--MEVEEFLKEAAVM 175 Query: 391 HQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVG-KREEIPVSNVAELLHQVSMG 448 ++ +P +V+L+GVC E ++ E G L +L R+E+ + + Q+S Sbjct: 176 KEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSA 235 Query: 449 MKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 M+YLE+KNF+HRDLAARN L+ H K++DFGLS+ + D YTA + K+P+KW AP Sbjct: 236 MEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGD--TYTAHAGAKFPIKWTAP 293 Query: 509 ECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPEL 568 E + + KFS +SDVW++GV +WE +YG PY + +V +E+ RME P CP ++ Sbjct: 294 ESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV 353 Query: 569 YALMSDCWIYKWEDRPDFLTVEQRMRACYY--SLASKVEGPPGSTQKAE 615 Y LM CW + DRP F + Q + S++ +VE G E Sbjct: 354 YELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVLE 402 Score = 115 bits (288), Expect = 6e-26, Method: Composition-based stats. Identities = 33/122 (27%), Positives = 59/122 (48%), Gaps = 7/122 (5%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69 +++G +SR A E+L +G+ +G FL+R+ S G +SL ++ R +H+ I +G Sbjct: 12 WYHGPVSR-NAAEYLLSSGI-NGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKL 69 Query: 70 AIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPC---NRPS--GLEPQPGVFDCLRDAMVR 124 ++ AEL +S DGL L P N+P+ G+ P ++ R + Sbjct: 70 YVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITM 129 Query: 125 DY 126 + Sbjct: 130 KH 131 >2FO0-A nrPDB Length = 495 Score = 422 bits (1084), Expect = e-118, Method: Composition-based stats. Identities = 147/460 (31%), Positives = 226/460 (49%), Gaps = 72/460 (15%) Query: 155 TTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSLIYGKTVYHYLI 213 + E+ WYH ++R AE L SG +G FL+R + G ++SL Y VYHY I Sbjct: 96 VNSLEKHSWYHGPVSRNAAEYLLSSG--INGSFLVRESESSPGQRSISLRYEGRVYHYRI 153 Query: 214 SQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAH 273 + GK + ++F+TL +LV + ADGLI L P Sbjct: 154 NTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAP------------------ 195 Query: 274 PSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLK 333 + +P SP D E++ + +K Sbjct: 196 -----------------------------KRNKPTVYGV----SPNYDKWEMERTDITMK 222 Query: 334 RDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL 393 +LG G +G V +GV++ K + VA+K LK+ T + EE ++EA +M ++ Sbjct: 223 H--------KLGGGQYGEVYEGVWK--KYSLTVAVKTLKEDT--MEVEEFLKEAAVMKEI 270 Query: 394 DNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVG-KREEIPVSNVAELLHQVSMGMKY 451 +P +V+L+GVC E ++ E G L +L R+E+ + + Q+S M+Y Sbjct: 271 KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEY 330 Query: 452 LEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI 511 LE+KNF+HR+LAARN L+ H K++DFGLS+ + D YTA + K+P+KW APE + Sbjct: 331 LEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTGD--TYTAHAGAKFPIKWTAPESL 388 Query: 512 NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYAL 571 + KFS +SDVW++GV +WE +YG PY + +V +E+ RME P CP ++Y L Sbjct: 389 AYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYEL 448 Query: 572 MSDCWIYKWEDRPDFLTVEQRMRACYY--SLASKVEGPPG 609 M CW + DRP F + Q + S++ +VE G Sbjct: 449 MRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELG 488 Score = 116 bits (290), Expect = 4e-26, Method: Composition-based stats. Identities = 33/122 (27%), Positives = 59/122 (48%), Gaps = 7/122 (5%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69 +++G +SR A E+L +G+ +G FL+R+ S G +SL ++ R +H+ I +G Sbjct: 104 WYHGPVSR-NAAEYLLSSGI-NGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKL 161 Query: 70 AIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPC---NRPS--GLEPQPGVFDCLRDAMVR 124 ++ AEL +S DGL L P N+P+ G+ P ++ R + Sbjct: 162 YVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITM 221 Query: 125 DY 126 + Sbjct: 222 KH 223 >1U59-A nrPDB Length = 287 Score = 408 bits (1048), Expect = e-114, Method: Composition-based stats. Identities = 280/280 (100%), Positives = 280/280 (100%) Query: 327 DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMRE 386 DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMRE Sbjct: 1 DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMRE 60 Query: 387 AQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVS 446 AQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVS Sbjct: 61 AQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVS 120 Query: 447 MGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY 506 MGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY Sbjct: 121 MGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY 180 Query: 507 APECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPP 566 APECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPP Sbjct: 181 APECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPP 240 Query: 567 ELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEG 606 ELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEG Sbjct: 241 ELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEG 280 >2H8H-A nrPDB Length = 535 Score = 400 bits (1029), Expect = e-112, Method: Composition-based stats. Identities = 138/466 (29%), Positives = 218/466 (46%), Gaps = 78/466 (16%) Query: 152 LIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSLI-----YG 205 + + + + WY +TR E+ER L + G FL+R + +G Y LS+ G Sbjct: 139 VAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKG 198 Query: 206 KTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGA 265 V HY I + +G + I T+F++L QLV Y ADG Sbjct: 199 LNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADG-------------------- 238 Query: 266 AAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEEL 325 + KP+ + +E P Sbjct: 239 --------------------------LCHRLTTVCPTSKPQTQGLAKDAWEIP------- 265 Query: 326 KDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMR 385 R++L + +++LG G FG V G + + VAIK LK GT E ++ Sbjct: 266 --------RESLRL-EVKLGQGCFGEVWMGTWNGTTR---VAIKTLKPGTMSP--EAFLQ 311 Query: 386 EAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEI-PVSNVAELLHQ 444 EAQ+M +L + +V+L V E + +V E G L FL G+ + + + ++ Q Sbjct: 312 EAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQ 371 Query: 445 VSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLK 504 ++ GM Y+E N+VHRDL A N+L+ K++DFGL++ + +D+ YTAR K+P+K Sbjct: 372 IASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIK 429 Query: 505 WYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPEC 564 W APE + +F+ +SDVWS+G+ + E + G+ PY M EV+ +E+G RM CPPEC Sbjct: 430 WTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPEC 489 Query: 565 PPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGS 610 P L+ LM CW + E+RP F ++ + + S + + PG Sbjct: 490 PESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQ--PGE 533 Score = 118 bits (296), Expect = 7e-27, Method: Composition-based stats. Identities = 34/129 (26%), Positives = 56/129 (43%), Gaps = 8/129 (6%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSL-----VHDVRFHHFPIERQ 64 +++G I+R E+E L A G FL+R+ + G Y LS+ + H+ I + Sbjct: 150 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 209 Query: 65 LNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAMVR 124 +G + I +L +YS+ DGL L C P+ +PQ + R Sbjct: 210 DSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVC--PTS-KPQTQGLAKDAWEIPR 266 Query: 125 DYVRQTWKL 133 + +R KL Sbjct: 267 ESLRLEVKL 275 >6F3F-A nrPDB Length = 455 Score = 399 bits (1026), Expect = e-111, Method: Composition-based stats. Identities = 138/466 (29%), Positives = 218/466 (46%), Gaps = 78/466 (16%) Query: 152 LIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSLI-----YG 205 + + + + WY +TR E+ER L + G FL+R + +G Y LS+ G Sbjct: 59 VAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKG 118 Query: 206 KTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGA 265 V HY I + +G + I T+F++L QLV Y ADG Sbjct: 119 LNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADG-------------------- 158 Query: 266 AAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEEL 325 + KP+ + +E P Sbjct: 159 --------------------------LCHRLTTVCPTSKPQTQGLAKDAWEIP------- 185 Query: 326 KDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMR 385 R++L + +++LG G FG V G + + VAIK LK GT E ++ Sbjct: 186 --------RESLRL-EVKLGQGCFGEVWMGTWNGTTR---VAIKTLKPGTMSP--EAFLQ 231 Query: 386 EAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEI-PVSNVAELLHQ 444 EAQ+M +L + +V+L V E + +V E G L FL G+ + + + ++ Q Sbjct: 232 EAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQ 291 Query: 445 VSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLK 504 ++ GM Y+E N+VHRDL A N+L+ K++DFGL++ + +D+ YTAR K+P+K Sbjct: 292 IASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIK 349 Query: 505 WYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPEC 564 W APE + +F+ +SDVWS+G+ + E + G+ PY M EV+ +E+G RM CPPEC Sbjct: 350 WTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPEC 409 Query: 565 PPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGS 610 P L+ LM CW + E+RP F ++ + + S + + PG Sbjct: 410 PESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQ--PGE 453 Score = 118 bits (295), Expect = 8e-27, Method: Composition-based stats. Identities = 34/129 (26%), Positives = 56/129 (43%), Gaps = 8/129 (6%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSL-----VHDVRFHHFPIERQ 64 +++G I+R E+E L A G FL+R+ + G Y LS+ + H+ I + Sbjct: 70 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 129 Query: 65 LNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAMVR 124 +G + I +L +YS+ DGL L C P+ +PQ + R Sbjct: 130 DSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVC--PTS-KPQTQGLAKDAWEIPR 186 Query: 125 DYVRQTWKL 133 + +R KL Sbjct: 187 ESLRLEVKL 195 >4XZ1-A nrPDB Length = 262 Score = 395 bits (1014), Expect = e-110, Method: Composition-based stats. Identities = 258/259 (99%), Positives = 258/259 (99%) Query: 1 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP 60 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP Sbjct: 4 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP 63 Query: 61 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD 120 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFD LRD Sbjct: 64 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDSLRD 123 Query: 121 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG 180 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG Sbjct: 124 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG 183 Query: 181 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK 240 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK Sbjct: 184 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK 243 Query: 241 LKADGLIYCLKEACPNSSA 259 LKADGLIYCLKEACPNSSA Sbjct: 244 LKADGLIYCLKEACPNSSA 262 >1AD5-A nrPDB Length = 438 Score = 392 bits (1008), Expect = e-109, Method: Composition-based stats. Identities = 131/464 (28%), Positives = 213/464 (45%), Gaps = 87/464 (18%) Query: 152 LIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSLI-----YG 205 + + E W+ ++R++AER+L + G F++R + +G+Y+LS+ G Sbjct: 55 VARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQG 114 Query: 206 KTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGA 265 TV HY I G + I + F TL +LV++ K DGL L Sbjct: 115 DTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKL--------------- 159 Query: 266 AAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEEL 325 + P + + P P + +E P Sbjct: 160 SVPCMSSKPQK--------------------------------PWEKDAWEIP------- 180 Query: 326 KDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMR 385 R++L + + +LG G FG V Y K VA+K +K G+ E + Sbjct: 181 --------RESLKL-EKKLGAGQFGEVWMATY---NKHTKVAVKTMKPGSMS--VEAFLA 226 Query: 386 EAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVG-KREEIPVSNVAELLHQ 444 EA +M L + +V+L V E + ++ E G L FL + + P+ + + Q Sbjct: 227 EANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQ 286 Query: 445 VSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLK 504 ++ GM ++E++N++HRDL A N+L+ KI+DFGL++ K+P+K Sbjct: 287 IAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLAR------------VGAKFPIK 334 Query: 505 WYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPEC 564 W APE INF F+ +SDVWS+G+ + E ++YG+ PY M PEV+ +E+G RM P C Sbjct: 335 WTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENC 394 Query: 565 PPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPP 608 P ELY +M CW + E+RP F ++ + Y + S+ + P Sbjct: 395 PEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP 438 Score = 117 bits (294), Expect = 1e-26, Method: Composition-based stats. Identities = 32/106 (30%), Positives = 46/106 (43%), Gaps = 5/106 (4%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLV-HDVR----FHHFPIERQ 64 +F+ ISR +AE L G G F++R + G Y LS+ +D R H+ I Sbjct: 66 WFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTL 125 Query: 65 LNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEP 110 NG + I+ EL + Y + DGL L PC +P Sbjct: 126 DNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKP 171 >1K9A-A nrPDB Length = 450 Score = 371 bits (952), Expect = e-103, Method: Composition-based stats. Identities = 141/454 (31%), Positives = 203/454 (44%), Gaps = 80/454 (17%) Query: 150 EKLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSLIYGKTV 208 E + A T MPW+H +TRE+AER LY G FL+R G Y L + V Sbjct: 69 EGVKAGTKLSLMPWFHGKITREQAERLLYP--PETGLFLVRESTNYPGDYTLCVSCEGKV 126 Query: 209 YHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAP 268 HY I A K I E F+ L QLVE+ AD Sbjct: 127 EHYRIMY-HASKLSIDEEVYFENLMQLVEHYTTDAD------------------------ 161 Query: 269 TLPAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDK 328 T KP+ M + + Y L K Sbjct: 162 ----------------------------GLCTRLIKPKVMEGTVAAQDEFYRSGWALNMK 193 Query: 329 KLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQ 388 +L L + +G G FG V G YR K VA+K +K + + EA Sbjct: 194 ELKLLQT--------IGKGEFGDVMLGDYRGNK----VAVKCIKNDAT---AQAFLAEAS 238 Query: 389 IMHQLDNPYIVRLIGVC--QAEALMLVMEMAGGGPLHKFLVGK-REEIPVSNVAELLHQV 445 +M QL + +V+L+GV + L +V E G L +L + R + + + V Sbjct: 239 VMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298 Query: 446 SMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKW 505 M+YLE NFVHRDLAARNVL+ + AK+SDFGL+K + + GK P+KW Sbjct: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS------STQDTGKLPVKW 352 Query: 506 YAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP 565 APE + +KFS++SDVWS+G+ +WE S+G+ PY ++ +V+ +E+G +M+ P CP Sbjct: 353 TAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP 412 Query: 566 PELYALMSDCWIYKWEDRPDFLTVEQRMRACYYS 599 P +Y +M +CW RP FL + +++ Sbjct: 413 PAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTH 446 Score = 92.8 bits (229), Expect = 4e-19, Method: Composition-based stats. Identities = 29/94 (30%), Positives = 44/94 (46%), Gaps = 3/94 (3%) Query: 8 LPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNG 67 +P+F+G I+R +AE L GLFL+R+ G Y L + + + H+ I + Sbjct: 80 MPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHAS- 136 Query: 68 TYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKP 101 +I +L E Y+ D DGL L KP Sbjct: 137 KLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKP 170 >1A81-A nrPDB Length = 254 Score = 369 bits (948), Expect = e-102, Method: Composition-based stats. Identities = 143/253 (56%), Positives = 192/253 (75%) Query: 4 PAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIER 63 A HLPFF+G+I+R EAE++L GM+DGL+LLRQ LGG+ LS+ H + HH+ IER Sbjct: 1 SANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIER 60 Query: 64 QLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAMV 123 +LNGTYAIAGG+ H PA+LC ++S++ DGL C L+KP NRP G++P+ G F+ L++ ++ Sbjct: 61 ELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLI 120 Query: 124 RDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQT 183 R+YV+QTW L+G+ALEQAIISQ PQ+EKLIATTAHE+MPW+H ++REE+E+ + G++T Sbjct: 121 REYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKT 180 Query: 184 DGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKA 243 +GKFL+R R G+YAL L++ V HY I +DK GK IPEG KFDTLWQLVE+ KA Sbjct: 181 NGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKA 240 Query: 244 DGLIYCLKEACPN 256 DGL+ L C Sbjct: 241 DGLLRVLTVPCQK 253 >4XI2-A nrPDB Length = 446 Score = 369 bits (947), Expect = e-102, Method: Composition-based stats. Identities = 134/452 (29%), Positives = 208/452 (46%), Gaps = 74/452 (16%) Query: 147 PQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGK 206 P A + E WY +TR +AE+ L + +G F++R + G Y +S+ Sbjct: 52 PSNYITEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK-EGGFIVRDSSKAGKYTVSVFAKS 110 Query: 207 T------VYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSAS 260 T + HY++ +Y + E F T+ +L+ Y + + GLI LK Sbjct: 111 TGEPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYP------- 163 Query: 261 NASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYS 320 ++ +K P Y S Sbjct: 164 --------------------------------------VSKQNKNAPSTAGLG-YGSWEI 184 Query: 321 DPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADT 380 DP++L FLK ELG G FG V+ G +R Q DVAIK++++G+ D Sbjct: 185 DPKDL----TFLK---------ELGTGQFGVVKYGKWRG---QYDVAIKMIREGSMSED- 227 Query: 381 EEMMREAQIMHQLDNPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVA 439 E + EA++M L + +V+L GVC + + ++ E G L +L R + Sbjct: 228 -EFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLL 286 Query: 440 ELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAG 499 E+ V M+YLE K F+HRDLAARN L+ ++ K+SDFGLS+ + D+ YT+ Sbjct: 287 EMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDE--YTSSVGS 344 Query: 500 KWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRME 559 K+P++W PE + + KFSS+SD+W++GV MWE S G+ PY++ E I QG R+ Sbjct: 345 KFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLY 404 Query: 560 CPPECPPELYALMSDCWIYKWEDRPDFLTVEQ 591 P +Y +M CW K ++RP F + Sbjct: 405 RPHLASERVYTIMYSCWHEKADERPSFKILLS 436 Score = 71.2 bits (173), Expect = 1e-12, Method: Composition-based stats. Identities = 23/118 (19%), Positives = 46/118 (38%), Gaps = 8/118 (6%) Query: 2 PDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSL------VHDVR 55 D ++ ++R++AE+ LK G +G F++R + G Y +S+ Sbjct: 60 EDSIEMYEWYSKHMTRSQAEQLLKQEG-KEGGFIVRDSSK-AGKYTVSVFAKSTGEPQGV 117 Query: 56 FHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPG 113 H+ + Y +A EL ++ + GL L+ P ++ + P Sbjct: 118 IRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSKQNKNAPSTA 175 >5C26-A nrPDB Length = 299 Score = 341 bits (876), Expect = 4e-94, Method: Composition-based stats. Identities = 182/294 (61%), Positives = 229/294 (77%), Gaps = 2/294 (0%) Query: 310 MDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIK 369 MDT VYESPY+DPEE++ K+++L R L + D ELG GNFG+V++G Y+M+K VA+K Sbjct: 1 MDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVK 60 Query: 370 VLK-QGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVG 428 +LK + + A +E++ EA +M QLDNPYIVR+IG+C+AE+ MLVMEMA GPL+K+L Sbjct: 61 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQ 120 Query: 429 KREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGA 488 R N+ EL+HQVSMGMKYLEE NFVHRDLAARNVLLV +HYAKISDFGLSKAL A Sbjct: 121 NRHVKD-KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRA 179 Query: 489 DDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEV 548 D++YY A++ GKWP+KWYAPECIN+ KFSS+SDVWS+GV MWEA SYGQKPY+ MKG EV Sbjct: 180 DENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 239 Query: 549 MAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLAS 602 A +E+G+RM CP CP E+Y LM+ CW Y E+RP F VE R+R YY + + Sbjct: 240 TAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 293 >4CSV-A nrPDB Length = 275 Score = 334 bits (857), Expect = 6e-92, Method: Composition-based stats. Identities = 108/274 (39%), Positives = 161/274 (58%), Gaps = 9/274 (3%) Query: 326 KDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMR 385 K + R + + + +LG G FG V +G +R I+VA+K LK+GT EE ++ Sbjct: 2 PHDKWEIPRSEITL-ERKLGSGQFGEVYEGKWR--NYNIEVAVKTLKEGTMS--VEEFLQ 56 Query: 386 EAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEI-PVSNVAELLH 443 EAQIM +L +P +V+L GVC E + ++ E G L +L + ++ Sbjct: 57 EAQIMKKLKHPNLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAA 116 Query: 444 QVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPL 503 QV+ GM YLE +NF+HRDLAARN L+ + K++DFGL++ + D+ YTAR+ K+P+ Sbjct: 117 QVASGMAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDE--YTARAGAKFPI 174 Query: 504 KWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE 563 KW APE I++ +FS +SDVW++G+ +WE +YGQ PY M G EV+ +E+G RM P Sbjct: 175 KWTAPEAISYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQG 234 Query: 564 CPPELYALMSDCWIYKWEDRPDFLTVEQRMRACY 597 CP E+Y LM CW E+RP F + + Sbjct: 235 CPEEIYELMLQCWNKSPEERPTFAETLHALETMF 268 >4P5Q-A nrPDB Length = 361 Score = 333 bits (855), Expect = 1e-91, Method: Composition-based stats. Identities = 110/281 (39%), Positives = 160/281 (56%), Gaps = 10/281 (3%) Query: 341 DIELGCGNFGSVRQGVYRM-RKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIV 399 D +G G FG V G ++ KK+I VAIK LK G + + + EA IM Q D+P I+ Sbjct: 38 DKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNII 97 Query: 400 RLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 RL GV +++ +M+V E G L FL + V + +L ++ GMKYL + +V Sbjct: 98 RLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYV 157 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 HRDLAARN+L+ + K+SDFGLS+ L D GK P++W +PE I +RKF+S Sbjct: 158 HRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTS 217 Query: 519 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIY 578 SDVWSYG+ +WE +SYG++PY +M +V+ +++G R+ P +CP LY LM DCW Sbjct: 218 ASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQK 277 Query: 579 KWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKAEAACA 619 +RP F + + K+ PGS + +A A Sbjct: 278 DRNNRPKFEQIVSIL--------DKLIRNPGSLKIITSAAA 310 >5MJB-A nrPDB Length = 305 Score = 326 bits (835), Expect = 2e-89, Method: Composition-based stats. Identities = 118/306 (38%), Positives = 166/306 (54%), Gaps = 16/306 (5%) Query: 320 SDPEELKDKKLFLKRDNLLIADIE--LGCGNFGSVRQGVYRMRKK-QIDVAIKVLKQGTE 376 SDP E + F K ++ IE +G G FG V +G ++ K +I VAIK LK G Sbjct: 10 SDPNEAVRE--FAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYS 67 Query: 377 KADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPV 435 + + + EA IM Q D+ I+RL GV ++ +M++ E L FL + V Sbjct: 68 EKQRRDFLSEASIMGQFDHRNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTV 127 Query: 436 SNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD--DSYY 493 + +L ++ GMKYL E N+VHRDLAARN+L+ + K+SDFGLS+ L D D Y Sbjct: 128 IQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTY 187 Query: 494 TARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIE 553 T+ GK P++W APE I +RKF+S SDVWSYG+ MWE +S+G++PY M +V+ IE Sbjct: 188 TSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIE 247 Query: 554 QGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQK 613 Q R+ P +CP L+ LM DCW RP F + + K+ P S + Sbjct: 248 QDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTL--------DKMIRNPASLKT 299 Query: 614 AEAACA 619 A Sbjct: 300 VATITA 305 >1JPA-A nrPDB Length = 312 Score = 323 bits (827), Expect = 2e-88, Method: Composition-based stats. Identities = 116/305 (38%), Positives = 164/305 (53%), Gaps = 18/305 (5%) Query: 318 PYSDPEELKDK----KLFLKRDNLLIADIE--LGCGNFGSVRQGVYRMRKK-QIDVAIKV 370 + DP +D + F K ++ IE +G G FG V G ++ K +I VAIK Sbjct: 9 IFIDPFTFEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKT 68 Query: 371 LKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGK 429 LK G + + + EA IM Q D+P ++ L GV +M++ E G L FL Sbjct: 69 LKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQN 128 Query: 430 REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD 489 + V + +L ++ GMKYL + N+VHRDLAARN+L+ + K+SDFGLS+ L D Sbjct: 129 DGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDD 188 Query: 490 --DSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPE 547 D YT+ GK P++W APE I +RKF+S SDVWSYG+ MWE +SYG++PY M + Sbjct: 189 TSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQD 248 Query: 548 VMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGP 607 V+ IEQ R+ P +CP L+ LM DCW RP F + + K+ Sbjct: 249 VINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTL--------DKMIRN 300 Query: 608 PGSTQ 612 P S + Sbjct: 301 PNSLK 305 >6NPU-A nrPDB Length = 298 Score = 320 bits (820), Expect = 1e-87, Method: Composition-based stats. Identities = 110/303 (36%), Positives = 171/303 (56%), Gaps = 18/303 (5%) Query: 311 DTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKV 370 + SP D E++ + +K +LG G +G V +GV++ K + VA+K Sbjct: 9 NLYFQGSPNYDKWEMERTDITMKH--------KLGGGQYGEVYEGVWK--KYSLTVAVKT 58 Query: 371 LKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVG- 428 LK+ T + EE ++EA +M ++ +P +V+L+GVC E ++ E G L +L Sbjct: 59 LKEDT--MEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLREC 116 Query: 429 KREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGA 488 R+E+ + + Q+S M+YLE+KNF+HRDLAARN L+ H K++DFGLS+ + Sbjct: 117 NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTG 176 Query: 489 DDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEV 548 D YTA + K+P+KW APE + + KFS +SDVW++GV +WE +YG PY + +V Sbjct: 177 D--TYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQV 234 Query: 549 MAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYY--SLASKVEG 606 +E+ RME P CP ++Y LM CW + DRP F + Q + S++ +VE Sbjct: 235 YELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEK 294 Query: 607 PPG 609 G Sbjct: 295 ELG 297 >5L6P-A nrPDB Length = 298 Score = 320 bits (820), Expect = 1e-87, Method: Composition-based stats. Identities = 117/304 (38%), Positives = 168/304 (55%), Gaps = 16/304 (5%) Query: 320 SDPEELKDKKLFLKRDNLLIADIE--LGCGNFGSVRQGVYRMRKK-QIDVAIKVLKQGTE 376 SDP E + F K ++ IE +G G FG V +G + + ++ VAIK LK G Sbjct: 3 SDPNEAVRE--FAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYT 60 Query: 377 KADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPV 435 + + + EA IM Q D+P I+RL GV ++ +M++ E L FL + V Sbjct: 61 ERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTV 120 Query: 436 SNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD--DSYY 493 + +L ++ GMKYL E N+VHRDLAARN+L+ + K+SDFGLS+ L D D Y Sbjct: 121 IQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTY 180 Query: 494 TARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIE 553 T+ GK P++W APE I +RKF+S SDVWSYG+ MWE +SYG++PY M +V+ +E Sbjct: 181 TSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVE 240 Query: 554 QGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQK 613 Q R+ P +CP L+ LM DCW+ RP F + + K+ P S + Sbjct: 241 QDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTL--------DKLIRNPASLKV 292 Query: 614 AEAA 617 +A Sbjct: 293 IASA 296 >3DKO-A nrPDB Length = 318 Score = 318 bits (815), Expect = 4e-87, Method: Composition-based stats. Identities = 113/300 (37%), Positives = 163/300 (54%), Gaps = 16/300 (5%) Query: 319 YSDPEELKDK----KLFLKRDNLLIADIE--LGCGNFGSVRQGVYRMRKKQ-IDVAIKVL 371 Y DPE +D F K + IE +G G FG V G ++ K+ + VAIK L Sbjct: 20 YIDPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTL 79 Query: 372 KQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKR 430 K G + + + EA IM Q D+P +V L GV + +M+V+E G L FL Sbjct: 80 KVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHD 139 Query: 431 EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADD 490 + V + +L ++ GM+YL + +VHRDLAARN+L+ + K+SDFGLS+ + D Sbjct: 140 GQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDP 199 Query: 491 SYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMA 550 + GK P++W APE I +RKF+S SDVWSYG+ MWE +SYG++PY M +V+ Sbjct: 200 EAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIK 259 Query: 551 FIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGS 610 IE+G R+ P +CP L+ LM DCW + +RP F + + K+ P S Sbjct: 260 AIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQIVGIL--------DKMIRNPNS 311 >2Y6O-A nrPDB Length = 291 Score = 318 bits (814), Expect = 5e-87, Method: Composition-based stats. Identities = 110/295 (37%), Positives = 158/295 (53%), Gaps = 12/295 (4%) Query: 329 KLFLKRDNLLIADIE--LGCGNFGSVRQGVYRMRKK-QIDVAIKVLKQGTEKADTEEMMR 385 + F K + IE +G G FG V G ++ K +I VAIK LK G + + Sbjct: 5 REFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLS 64 Query: 386 EAQIMHQLDNPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQ 444 EA IM Q D+P I+ L GV + +M++ E G L FL V + +L Sbjct: 65 EASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRG 124 Query: 445 VSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLK 504 + GMKYL + ++VHRDLAARN+L+ + K+SDFG+S+ L D GK P++ Sbjct: 125 IGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIR 184 Query: 505 WYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPEC 564 W APE I +RKF+S SDVWSYG+ MWE +SYG++PY M +V+ IE+G R+ P +C Sbjct: 185 WTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDC 244 Query: 565 PPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKAEAACA 619 P L+ LM DCW + DRP F + + K+ P S ++ + + Sbjct: 245 PIALHQLMLDCWQKERSDRPKFGQIVNML--------DKLIRNPNSLKRTGSESS 291 >2PL0-A nrPDB Length = 289 Score = 317 bits (813), Expect = 9e-87, Method: Composition-based stats. Identities = 101/283 (35%), Positives = 161/283 (56%), Gaps = 9/283 (3%) Query: 327 DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMRE 386 + + + R+ L + + LG G FG V G Y VA+K LKQG+ D + E Sbjct: 15 EDEWEVPRETLKLVE-RLGAGQFGEVWMGYY---NGHTKVAVKSLKQGSMSPDA--FLAE 68 Query: 387 AQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKRE-EIPVSNVAELLHQV 445 A +M QL + +VRL V E + ++ E G L FL ++ ++ + ++ Q+ Sbjct: 69 ANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQI 128 Query: 446 SMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKW 505 + GM ++EE+N++HRDL A N+L+ + KI+DFGL++ + +D+ YTAR K+P+KW Sbjct: 129 AEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--EDNEYTAREGAKFPIKW 186 Query: 506 YAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP 565 APE IN+ F+ +SDVWS+G+ + E +++G+ PY M PEV+ +E+G RM P CP Sbjct: 187 TAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP 246 Query: 566 PELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPP 608 ELY LM CW + EDRP F + + + + + + P Sbjct: 247 EELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP 289 >2R2P-A nrPDB Length = 295 Score = 315 bits (808), Expect = 3e-86, Method: Composition-based stats. Identities = 108/283 (38%), Positives = 157/283 (55%), Gaps = 2/283 (0%) Query: 319 YSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKK-QIDVAIKVLKQGTEK 377 Y DP + + + + + +G G FG V G ++ K ++ VAIK LK G + Sbjct: 5 YEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTE 64 Query: 378 ADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPVS 436 + + EA IM Q D+P I+ L GV +++ +M+V E G L FL + V Sbjct: 65 KQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVI 124 Query: 437 NVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTAR 496 + +L +S GMKYL + +VHRDLAARN+L+ + K+SDFGLS+ L D Sbjct: 125 QLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTT 184 Query: 497 SAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK 556 GK P++W APE I FRKF+S SDVWSYG+ MWE +SYG++PY +M +V+ +E+G Sbjct: 185 RGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGY 244 Query: 557 RMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYS 599 R+ P +CP LY LM DCW + RP F + + + Sbjct: 245 RLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLIRN 287 >2XYN-A nrPDB Length = 292 Score = 315 bits (806), Expect = 5e-86, Method: Composition-based stats. Identities = 105/276 (38%), Positives = 160/276 (57%), Gaps = 9/276 (3%) Query: 326 KDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMR 385 K ++R ++ + +LG G +G V GV++ K + VA+K LK+ T + EE ++ Sbjct: 23 SMDKWEMERTDITMKH-KLGGGQYGEVYVGVWK--KYSLTVAVKTLKEDT--MEVEEFLK 77 Query: 386 EAQIMHQLDNPYIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVG-KREEIPVSNVAELLH 443 EA +M ++ +P +V+L+GVC +V E G L +L REE+ + + Sbjct: 78 EAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMAT 137 Query: 444 QVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPL 503 Q+S M+YLE+KNF+HRDLAARN L+ H K++DFGLS+ + D YTA + K+P+ Sbjct: 138 QISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGD--TYTAHAGAKFPI 195 Query: 504 KWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE 563 KW APE + + FS +SDVW++GV +WE +YG PY + +V +E+G RME P Sbjct: 196 KWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEG 255 Query: 564 CPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYS 599 CPP++Y LM CW + DRP F Q ++ Sbjct: 256 CPPKVYELMRACWKWSPADRPSFAETHQAFETMFHD 291 >5SYS-A nrPDB Length = 286 Score = 312 bits (800), Expect = 2e-85, Method: Composition-based stats. Identities = 101/287 (35%), Positives = 160/287 (55%), Gaps = 11/287 (3%) Query: 325 LKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMM 384 L + R++L + +++LG G FG G + + VAIK LK GT E + Sbjct: 8 LAKDAWEIPRESLRL-EVKLGQGCFGECWMGTWNGTTR---VAIKTLKPGTMSP--EAFL 61 Query: 385 REAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEI-PVSNVAELLH 443 +EAQ+M +L + +V+L V E + +V E G L FL G+ + + + ++ Sbjct: 62 QEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAA 121 Query: 444 QVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPL 503 Q++ GM Y+E N+VHRDL A N+L+ K++DFGL++ + +D+ YTAR K+P+ Sbjct: 122 QIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPI 179 Query: 504 KWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE 563 KW APE + +F+ +SDVWS+G+ + E + G+ PY M EV+ +E+G RM CPPE Sbjct: 180 KWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE 239 Query: 564 CPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGS 610 CP L+ LM CW E+RP F ++ + + S + + PG Sbjct: 240 CPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQ--PGE 284 >4PDO-A nrPDB Length = 299 Score = 312 bits (800), Expect = 2e-85, Method: Composition-based stats. Identities = 108/283 (38%), Positives = 156/283 (55%), Gaps = 3/283 (1%) Query: 319 YSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMR--KKQIDVAIKVLKQGTE 376 Y DP + K + + +G G FG V +G+ + KK++ VAIK LK G Sbjct: 17 YEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYT 76 Query: 377 KADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPV 435 + + + EA IM Q + I+RL GV + + +M++ E G L KFL K E V Sbjct: 77 EKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSV 136 Query: 436 SNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTA 495 + +L ++ GMKYL N+VHRDLAARN+L+ + K+SDFGLS+ L D Sbjct: 137 LQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYT 196 Query: 496 RSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG 555 S GK P++W APE I++RKF+S SDVWS+G+ MWE ++YG++PY ++ EVM I G Sbjct: 197 TSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDG 256 Query: 556 KRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYY 598 R+ P +CP +Y LM CW + RP F + + Sbjct: 257 FRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIR 299 >2VWV-A nrPDB Length = 302 Score = 311 bits (798), Expect = 5e-85, Method: Composition-based stats. Identities = 116/300 (38%), Positives = 162/300 (54%), Gaps = 16/300 (5%) Query: 321 DPEELKDKKLFLKRDNLLIADIE--LGCGNFGSVRQGVYRM-RKKQIDVAIKVLKQGTEK 377 DP E + F K ++ IE +G G FG V +G + KK+ VAIK LK G + Sbjct: 1 DPNEAVRE--FAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTE 58 Query: 378 ADTEEMMREAQIMHQLDNPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVS 436 E + EA IM Q ++P I+RL GV +M++ E G L FL + V Sbjct: 59 RQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVI 118 Query: 437 NVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD--DSYYT 494 + +L ++ GM+YL E ++VHRDLAARN+L+ + K+SDFGLS+ L + D T Sbjct: 119 QLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTET 178 Query: 495 ARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 554 + GK P++W APE I FRKF+S SD WSYG+ MWE +S+G++PY M +V+ IEQ Sbjct: 179 SSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQ 238 Query: 555 GKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKA 614 R+ PP+CP L+ LM DCW RP F V + K+ P S + Sbjct: 239 DYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSAL--------DKMIRNPASLKIV 290 >2HK5-A nrPDB Length = 270 Score = 311 bits (796), Expect = 8e-85, Method: Composition-based stats. Identities = 98/278 (35%), Positives = 155/278 (55%), Gaps = 11/278 (3%) Query: 320 SDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKAD 379 P E + R++L + + +LG G FG V Y K VA+K +K G+ Sbjct: 2 QKPWE--KDAWEIPRESLKL-EKKLGAGQFGEVWMATY---NKHTKVAVKTMKPGSMS-- 53 Query: 380 TEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVG-KREEIPVSNV 438 E + EA +M L + +V+L V E + ++ E G L FL + + P+ + Sbjct: 54 VEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKL 113 Query: 439 AELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSA 498 + Q++ GM ++E++N++HRDL A N+L+ KI+DFGL++ + +D+ YTAR Sbjct: 114 IDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVI--EDNEYTAREG 171 Query: 499 GKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM 558 K+P+KW APE INF F+ +SDVWS+G+ + E ++YG+ PY M PEV+ +E+G RM Sbjct: 172 AKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRM 231 Query: 559 ECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRAC 596 P CP ELY +M CW + E+RP F ++ + Sbjct: 232 PRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDF 269 >2DQ7-X nrPDB Length = 283 Score = 310 bits (794), Expect = 1e-84, Method: Composition-based stats. Identities = 101/282 (35%), Positives = 157/282 (55%), Gaps = 11/282 (3%) Query: 330 LFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQI 389 + R++L + LG G FG V G + VAIK LK GT E + EAQI Sbjct: 4 WEIPRESLQLIK-RLGNGQFGEVWMGTW---NGNTKVAIKTLKPGTMSP--ESFLEEAQI 57 Query: 390 MHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLV-GKREEIPVSNVAELLHQVSMG 448 M +L + +V+L V E + +V E G L FL G+ + + N+ ++ QV+ G Sbjct: 58 MKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAG 117 Query: 449 MKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 M Y+E N++HRDL + N+L+ N KI+DFGL++ + +D+ YTAR K+P+KW AP Sbjct: 118 MAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI--EDNEYTARQGAKFPIKWTAP 175 Query: 509 ECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPEL 568 E + +F+ +SDVWS+G+ + E ++ G+ PY M EV+ +E+G RM CP +CP L Sbjct: 176 EAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISL 235 Query: 569 YALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGS 610 + LM CW E+RP F ++ + + + + + PG Sbjct: 236 HELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQ--PGE 275 >3KUL-B nrPDB Length = 325 Score = 309 bits (791), Expect = 3e-84, Method: Composition-based stats. Identities = 113/292 (38%), Positives = 157/292 (53%), Gaps = 4/292 (1%) Query: 315 YESPYSDPEELKDKKLFLKRDNLLIADIE--LGCGNFGSVRQGVYRMRKKQ-IDVAIKVL 371 Y P++ E + + F + IE +G G+ G V G R+ ++ + VAIK L Sbjct: 26 YAEPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKAL 85 Query: 372 KQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEAL-MLVMEMAGGGPLHKFLVGKR 430 K G + + + EA IM Q D+P I+RL GV L M+V E G L FL Sbjct: 86 KAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHD 145 Query: 431 EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADD 490 + + + +L V GM+YL + +VHRDLAARNVL+ + K+SDFGLS+ L D Sbjct: 146 GQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDP 205 Query: 491 SYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMA 550 + GK P++W APE I FR FSS SDVWS+GV MWE L+YG++PY M +V++ Sbjct: 206 DAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVIS 265 Query: 551 FIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLAS 602 +E+G R+ P CP L+ LM DCW RP F + + A S S Sbjct: 266 SVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVLDALIRSPES 317 >5A46-A nrPDB Length = 386 Score = 308 bits (790), Expect = 3e-84, Method: Composition-based stats. Identities = 105/339 (30%), Positives = 169/339 (49%), Gaps = 33/339 (9%) Query: 287 LNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGC 346 +NS P+R++S P M S YE P +D + L RD L++ LG Sbjct: 1 MNSGVLLVRPSRLSSSGTP--MLAGVSEYELP-------EDPRWELPRDRLVLGK-PLGE 50 Query: 347 GNFGSVRQGVYRMRKKQ-----IDVAIKVLKQGTEKADTEEMMREAQIMHQL-DNPYIVR 400 G FG V K VA+K+LK + D +++ E ++M + + I+ Sbjct: 51 GCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIIN 110 Query: 401 LIGVCQAEA-LMLVMEMAGGGPLHKFLVGKR---------------EEIPVSNVAELLHQ 444 L+G C + L +++E A G L ++L +R E++ ++ +Q Sbjct: 111 LLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQ 170 Query: 445 VSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLK 504 V+ GM+YL K +HRDLAARNVL+ + KI+DFGL++ + D YY + G+ P+K Sbjct: 171 VARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHID-YYKKTTNGRLPVK 229 Query: 505 WYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPEC 564 W APE + R ++ +SDVWS+GV +WE + G PY + E+ +++G RM+ P C Sbjct: 230 WMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNC 289 Query: 565 PPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASK 603 ELY +M DCW RP F + + + +++ Sbjct: 290 TNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 328 >4EBW-A nrPDB Length = 304 Score = 308 bits (790), Expect = 3e-84, Method: Composition-based stats. Identities = 109/288 (37%), Positives = 167/288 (57%), Gaps = 4/288 (1%) Query: 317 SPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYR-MRKKQIDVAIKVLKQGT 375 + + ++R+ + + +G G FG V QG+Y + VAIK K T Sbjct: 20 LYFQGAMGSSTRDYEIQRERIELGRC-IGEGQFGDVHQGIYMSPENPALAVAIKTCKNCT 78 Query: 376 EKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPV 435 + E+ ++EA M Q D+P+IV+LIGV + ++ME+ G L FL ++ + + Sbjct: 79 SDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDL 138 Query: 436 SNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTA 495 +++ +Q+S + YLE K FVHRD+AARNVL+ + K+ DFGLS+ + +DS Y Sbjct: 139 ASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYM--EDSTYYK 196 Query: 496 RSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG 555 S GK P+KW APE INFR+F+S SDVW +GV MWE L +G KP++ +K +V+ IE G Sbjct: 197 ASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENG 256 Query: 556 KRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASK 603 +R+ PP CPP LY+LM+ CW Y RP F ++ ++ ++ Sbjct: 257 ERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQ 304 >2PSQ-A nrPDB Length = 370 Score = 307 bits (786), Expect = 1e-83, Method: Composition-based stats. Identities = 100/319 (31%), Positives = 163/319 (51%), Gaps = 31/319 (9%) Query: 307 PMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQ----GVYRMRKK 362 PM S YE P +D K RD L + LG G FG V G+ + + K Sbjct: 60 PMLAGVSEYELP-------EDPKWEFPRDKLTLGK-PLGEGCFGQVVMAEAVGIDKDKPK 111 Query: 363 Q-IDVAIKVLKQGTEKADTEEMMREAQIMHQL-DNPYIVRLIGVCQAEA-LMLVMEMAGG 419 + + VA+K+LK + D +++ E ++M + + I+ L+G C + L +++E A Sbjct: 112 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 171 Query: 420 GPLHKFLVGKR---------------EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAA 464 G L ++L +R E++ ++ +Q++ GM+YL + +HRDLAA Sbjct: 172 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 231 Query: 465 RNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWS 524 RNVL+ + KI+DFGL++ + D YY + G+ P+KW APE + R ++ +SDVWS Sbjct: 232 RNVLVTENNVMKIADFGLARDINNID-YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWS 290 Query: 525 YGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRP 584 +GV MWE + G PY + E+ +++G RM+ P C ELY +M DCW RP Sbjct: 291 FGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP 350 Query: 585 DFLTVEQRMRACYYSLASK 603 F + + + ++ Sbjct: 351 TFKQLVEDLDRILTLTTNE 369 >2J0K-A nrPDB Length = 656 Score = 306 bits (785), Expect = 1e-83, Method: Composition-based stats. Identities = 119/347 (34%), Positives = 183/347 (52%), Gaps = 13/347 (3%) Query: 253 ACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDT 312 C + + S P + + P+ + G ++ D + + Sbjct: 317 YCRLVNGATQSFIIRPQKEGERALPSIPK--LANNEKQGVRSHTVSVSETDDYAEIIDEE 374 Query: 313 SVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYR-MRKKQIDVAIKVL 371 Y P + E++ +++ L R +G G FG V QG+Y + VAIK Sbjct: 375 DTYTMPSTRDYEIQRERIELGR--------CIGEGQFGDVHQGIYMSPENPAMAVAIKTC 426 Query: 372 KQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKRE 431 K T + E+ ++EA M Q D+P+IV+LIGV + ++ME+ G L FL ++ Sbjct: 427 KNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKF 486 Query: 432 EIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDS 491 + ++++ +Q+S + YLE K FVHRD+AARNVL+ K+ DFGLS+ + +DS Sbjct: 487 SLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYM--EDS 544 Query: 492 YYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAF 551 Y S GK P+KW APE INFR+F+S SDVW +GV MWE L +G KP++ +K +V+ Sbjct: 545 TYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGR 604 Query: 552 IEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYY 598 IE G+R+ PP CPP LY+LM+ CW Y RP F ++ ++ Sbjct: 605 IENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILE 651 >3A4O-X nrPDB Length = 286 Score = 306 bits (783), Expect = 3e-83, Method: Composition-based stats. Identities = 100/281 (35%), Positives = 153/281 (54%), Gaps = 10/281 (3%) Query: 330 LFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQI 389 + R+++ + LG G FG V G Y K VA+K LK GT + + EA + Sbjct: 8 WEIPRESIKLVK-RLGAGQFGEVWMGYYNNSTK---VAVKTLKPGTMS--VQAFLEEANL 61 Query: 390 MHQLDNPYIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVG-KREEIPVSNVAELLHQVSM 447 M L + +VRL V E + ++ E G L FL + ++ + + + Q++ Sbjct: 62 MKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAE 121 Query: 448 GMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYA 507 GM Y+E KN++HRDL A NVL+ KI+DFGL++ + +D+ YTAR K+P+KW A Sbjct: 122 GMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVI--EDNEYTAREGAKFPIKWTA 179 Query: 508 PECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPE 567 PE INF F+ +SDVWS+G+ ++E ++YG+ PY +VM + QG RM CP E Sbjct: 180 PEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDE 239 Query: 568 LYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPP 608 LY +M CW K E+RP F ++ + Y + + + P Sbjct: 240 LYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP 280 >3TT0-A nrPDB Length = 382 Score = 305 bits (782), Expect = 3e-83, Method: Composition-based stats. Identities = 99/320 (30%), Positives = 160/320 (50%), Gaps = 31/320 (9%) Query: 306 RPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQ-- 363 + M S YE P +D + L RD L++ LG G FG V K Sbjct: 47 QGMLAGVSEYELP-------EDPRWELPRDRLVLGK-PLGEGAFGQVVLAEAIGLDKDKP 98 Query: 364 ---IDVAIKVLKQGTEKADTEEMMREAQIMHQL-DNPYIVRLIGVCQAEA-LMLVMEMAG 418 VA+K+LK + D +++ E ++M + + I+ L+G C + L +++E A Sbjct: 99 NRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 158 Query: 419 GGPLHKFLVGKR---------------EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLA 463 G L ++L +R E++ ++ +QV+ GM+YL K +HRDLA Sbjct: 159 KGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLA 218 Query: 464 ARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVW 523 ARNVL+ + KI+DFGL++ + D YY + G+ P+KW APE + R ++ +SDVW Sbjct: 219 ARNVLVTEDNVMKIADFGLARDIHHID-YYKKTTNGRLPVKWMAPEALFDRIYTHQSDVW 277 Query: 524 SYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDR 583 S+GV +WE + G PY + E+ +++G RM+ P C ELY +M DCW R Sbjct: 278 SFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQR 337 Query: 584 PDFLTVEQRMRACYYSLASK 603 P F + + + +++ Sbjct: 338 PTFKQLVEDLDRIVALTSNQ 357 >4E93-A nrPDB Length = 377 Score = 302 bits (774), Expect = 2e-82, Method: Composition-based stats. Identities = 101/277 (36%), Positives = 159/277 (57%), Gaps = 5/277 (1%) Query: 323 EELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEE 382 + K L ++L++ + ++G GNFG V G R+R VA+K ++ + Sbjct: 102 RAVPKDKWVLNHEDLVLGE-QIGRGNFGEVFSG--RLRADNTLVAVKSCRETLPPDLKAK 158 Query: 383 MMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAEL 441 ++EA+I+ Q +P IVRLIGVC Q + + +VME+ GG FL + + V + ++ Sbjct: 159 FLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQM 218 Query: 442 LHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKW 501 + + GM+YLE K +HRDLAARN L+ ++ KISDFG+S+ AD Y + + Sbjct: 219 VGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSRE-EADGVYAASGGLRQV 277 Query: 502 PLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECP 561 P+KW APE +N+ ++SS SDVWS+G+ +WE S G PY + + F+E+G R+ CP Sbjct: 278 PVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCP 337 Query: 562 PECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYY 598 CP ++ LM CW Y+ RP F T+ Q +++ Sbjct: 338 ELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRK 374 Score = 62.3 bits (150), Expect = 7e-10, Method: Composition-based stats. Identities = 25/95 (26%), Positives = 42/95 (44%), Gaps = 11/95 (11%) Query: 144 SQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLI 203 S P+V+K HE WYH ++ R E L G FL+R + + Y LS++ Sbjct: 1 SMIPEVQK----PLHE-QLWYHGAIPRAEVAELLV----HSGDFLVRESQGKQEYVLSVL 51 Query: 204 YGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEY 238 + H++I EG F ++ L+++ Sbjct: 52 WDGLPRHFIIQSLDN--LYRLEGEGFPSIPLLIDH 84 Score = 50.8 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 24/86 (27%), Positives = 38/86 (44%), Gaps = 7/86 (8%) Query: 1 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP 60 + P +++G+I RAE E L + G FL+R+ YVLS++ D HF Sbjct: 6 VQKPLHEQLWYHGAIPRAEVAELLVHS----GDFLVRESQ-GKQEYVLSVLWDGLPRHFI 60 Query: 61 IERQLNGTYAIAGGKAHCGPAELCEF 86 I+ N Y + G+ L + Sbjct: 61 IQSLDN-LYRL-EGEGFPSIPLLIDH 84 >5EG3-A nrPDB Length = 334 Score = 302 bits (774), Expect = 3e-82, Method: Composition-based stats. Identities = 96/320 (30%), Positives = 162/320 (50%), Gaps = 31/320 (9%) Query: 306 RPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQ----GVYRMRK 361 PM S +E P +D K RD L + LG G FG V G+ + + Sbjct: 13 DPMLAGVSEFELP-------EDPKWEFPRDKLTLGK-PLGEGAFGQVVMAEAVGIDKDKP 64 Query: 362 KQ-IDVAIKVLKQGTEKADTEEMMREAQIMHQL-DNPYIVRLIGVCQAEA-LMLVMEMAG 418 K+ + VA+K+LK + D +++ E ++M + + I+ L+G C + L +++ A Sbjct: 65 KEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVAYAS 124 Query: 419 GGPLHKFLVGKR---------------EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLA 463 G L ++L +R E++ ++ +Q++ GM+YL + +HRDLA Sbjct: 125 KGNLREYLRARRPPGMELSPDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLA 184 Query: 464 ARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVW 523 ARNVL+ + KI+DFGL++ + D ++ + G+ P+KW APE + R ++ +SDVW Sbjct: 185 ARNVLVTENNVMKIADFGLARDINNID-FFKETTNGRLPVKWMAPEALFDRVYTHQSDVW 243 Query: 524 SYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDR 583 S+GV MWE + G PY + E+ +++G RM+ P C ELY +M DCW R Sbjct: 244 SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR 303 Query: 584 PDFLTVEQRMRACYYSLASK 603 P F + + + ++ Sbjct: 304 PTFKQLVEDLDRILTLTTNE 323 >3GQL-A nrPDB Length = 326 Score = 301 bits (772), Expect = 5e-82, Method: Composition-based stats. Identities = 98/316 (31%), Positives = 158/316 (50%), Gaps = 31/316 (9%) Query: 310 MDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQ-----I 364 S YE P +D + L RD L++ LG G FG V K Sbjct: 10 AGVSEYELP-------EDPRWELPRDRLVLGK-PLGEGAFGQVVLAEAIGLDKDKPNRVT 61 Query: 365 DVAIKVLKQGTEKADTEEMMREAQIMHQL-DNPYIVRLIGVCQAEA-LMLVMEMAGGGPL 422 VA+K+LK + D +++ E ++M + + I+ L+G C + L +++E A G L Sbjct: 62 KVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 121 Query: 423 HKFLVGKR---------------EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNV 467 ++L +R E++ ++ +QV+ GM+YL K +HRDLAARNV Sbjct: 122 REYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 181 Query: 468 LLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGV 527 L+ + KI+DFGL++ + D YY + G+ P+KW APE + R ++ +SDVWS+GV Sbjct: 182 LVTEDNVMKIADFGLARDIHHID-YYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGV 240 Query: 528 TMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFL 587 +WE + G PY + E+ +++G RM+ P C ELY +M DCW RP F Sbjct: 241 LLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFK 300 Query: 588 TVEQRMRACYYSLASK 603 + + + +++ Sbjct: 301 QLVEDLDRIVALTSNQ 316 >4H1J-A nrPDB Length = 293 Score = 300 bits (769), Expect = 9e-82, Method: Composition-based stats. Identities = 102/272 (37%), Positives = 159/272 (58%), Gaps = 4/272 (1%) Query: 332 LKRDNLLIADIELGCGNFGSVRQGVY-RMRKKQIDVAIKVLKQGTEKADTEEMMREAQIM 390 + R+++++ I LG G FG V +GVY + ++I+VA+K K+ + E+ M EA IM Sbjct: 21 IAREDVVLNRI-LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIM 79 Query: 391 HQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMK 450 LD+P+IV+LIG+ + E ++ME+ G L +L + + V + Q+ M Sbjct: 80 KNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMA 139 Query: 451 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510 YLE N VHRD+A RN+L+ + K+ DFGLS+ + +D Y S + P+KW +PE Sbjct: 140 YLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDED--YYKASVTRLPIKWMSPES 197 Query: 511 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYA 570 INFR+F++ SDVW + V MWE LS+G++P+ ++ +V+ +E+G R+ P CPP LY Sbjct: 198 INFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYT 257 Query: 571 LMSDCWIYKWEDRPDFLTVEQRMRACYYSLAS 602 LM+ CW Y DRP F + + Y Sbjct: 258 LMTRCWDYDPSDRPRFTELVCSLSDVYQMEKD 289 >4XCU-A nrPDB Length = 300 Score = 299 bits (767), Expect = 2e-81, Method: Composition-based stats. Identities = 100/288 (34%), Positives = 155/288 (53%), Gaps = 15/288 (5%) Query: 327 DKKLFLKRDNLLIADIELGCGNFGSVRQ----GVYRMRKKQ-IDVAIKVLKQGTEKADTE 381 D RD L++ LG G FG V + G+ R Q VA+K+LK D Sbjct: 9 DPLWEFPRDRLVLGK-PLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLA 67 Query: 382 EMMREAQIMHQL-DNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVS--- 436 +++ E ++M + + I+ L+GVC E L +++E A G L +FL +R Sbjct: 68 DLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPL 127 Query: 437 ---NVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYY 493 + +QV+ GM+YLE + +HRDLAARNVL+ + KI+DFGL++ + D YY Sbjct: 128 SFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHID-YY 186 Query: 494 TARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIE 553 S G+ P+KW APE + R ++ +SDVWS+G+ +WE + G PY + E+ + + Sbjct: 187 KKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLR 246 Query: 554 QGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLA 601 +G RM+ PP CPPELY LM +CW RP F + + + +++ Sbjct: 247 EGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVS 294 >6GQK-A nrPDB Length = 328 Score = 299 bits (765), Expect = 3e-81, Method: Composition-based stats. Identities = 101/300 (33%), Positives = 146/300 (48%), Gaps = 24/300 (8%) Query: 317 SPYSDPEELK-DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQ---IDVAIKVLK 372 Y DP +L D K R+ L LG G FG V + + K + VA+K+LK Sbjct: 22 YSYIDPTQLPYDHKWEFPRNRLSFGKT-LGAGAFGKVVEATAQGLIKSDAAMTVAVKMLK 80 Query: 373 QGTEKADTEEMMREAQIMHQL-DNPYIVRLIGVCQAEALMLV-MEMAGGGPLHKFLVGKR 430 + E +M E +++ L ++ IV L+G C LV E G L FL KR Sbjct: 81 PSAHSTEREALMSELKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKR 140 Query: 431 EEI---------------PVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYA 475 +E + ++ +QV+ GM +L KN +HRDLAARN+LL + + Sbjct: 141 DEFVPYKVAPEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNIT 200 Query: 476 KISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSY 535 KI DFGL++ + +DS Y + + P+KW APE I ++ SDVWSYG+ +WE S Sbjct: 201 KICDFGLARDI-KNDSNYVDKGNARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSL 259 Query: 536 GQKPYKKMK-GPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMR 594 G PY M + I++G RM P P E+Y +M CW + RP F + Q + Sbjct: 260 GSSPYPGMPVDSKFYKMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQIVQDIE 319 >5AMN-A nrPDB Length = 299 Score = 298 bits (763), Expect = 5e-81, Method: Composition-based stats. Identities = 97/285 (34%), Positives = 155/285 (54%), Gaps = 15/285 (5%) Query: 325 LKDKKLFLKRDNLLIADIELGCGNFGSVRQGV---YRMRKKQIDVAIKVLKQGTEKADTE 381 L+D K R NL++ LG G FG V + + R VA+K+LK+ ++ Sbjct: 13 LEDPKWEFPRKNLVLGKT-LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELR 71 Query: 382 EMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIP------ 434 +++ E ++ Q+++P++++L G C + L+L++E A G L FL R+ P Sbjct: 72 DLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDER 131 Query: 435 ---VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDS 491 + ++ Q+S GM+YL E VHRDLAARN+L+ KISDFGLS+ + +DS Sbjct: 132 ALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDS 191 Query: 492 YYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAF 551 Y RS G+ P+KW A E + ++++SDVWS+GV +WE ++ G PY + + Sbjct: 192 -YVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNL 250 Query: 552 IEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRAC 596 ++ G RME P C E+Y LM CW + + RP F + + + Sbjct: 251 LKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM 295 >4K33-A nrPDB Length = 325 Score = 293 bits (751), Expect = 1e-79, Method: Composition-based stats. Identities = 99/310 (31%), Positives = 157/310 (50%), Gaps = 31/310 (10%) Query: 307 PMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQ----GVYRMRK- 361 P + S E P D K L R L + LG G FG V G+ + R Sbjct: 15 PTLANVSELELP-------ADPKWELSRARLTLGK-PLGEGAFGQVVMAEAIGIDKDRAA 66 Query: 362 KQIDVAIKVLKQGTEKADTEEMMREAQIMHQL-DNPYIVRLIGVC-QAEALMLVMEMAGG 419 K + VA+K+LK D +++ E ++M + + I+ L+G C Q L +++E A Sbjct: 67 KPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAK 126 Query: 420 GPLHKFLVGKR---------------EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAA 464 G L +FL +R E++ ++ +QV+ GM+YL + +HRDLAA Sbjct: 127 GNLREFLRARRPPGLDYSFDTSKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAA 186 Query: 465 RNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWS 524 RNVL+ + KI+DFGL++ + D YY + G+ P+KW APE + R ++ +SDVWS Sbjct: 187 RNVLVTEDNVMKIADFGLARDVHNLD-YYKETTNGRLPVKWMAPEALFDRVYTHQSDVWS 245 Query: 525 YGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRP 584 +GV +WE + G PY + E+ +++G RM+ P C +LY +M +CW RP Sbjct: 246 FGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRP 305 Query: 585 DFLTVEQRMR 594 F + + + Sbjct: 306 TFKQLVEDLD 315 >4OLI-A nrPDB Length = 645 Score = 293 bits (749), Expect = 2e-79, Method: Composition-based stats. Identities = 115/358 (32%), Positives = 165/358 (46%), Gaps = 43/358 (12%) Query: 283 RIDTLNSDGYTPEPA-----RITSPDKPRPMPMD-----TSVYESPYSDPEELKDKKLFL 332 ++ TL S T EP R D R P + T +SP SDP + L Sbjct: 298 QLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKK 357 Query: 333 KRDNLLIADIELGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADTEEMMREAQIM 390 RD LG G+FG V Y VA+K LK +E I+ Sbjct: 358 IRD--------LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDIL 409 Query: 391 HQLDNPYIVRLIGVCQAEA---LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSM 447 L + +I++ G C+ + L LVME G L +L R I ++ + Q+ Sbjct: 410 RTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYL--PRHSIGLAQLLLFAQQICE 467 Query: 448 GMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYA 507 GM YL ++++HR+LAARNVLL N KI DFGL+KA+ YY R G P+ WYA Sbjct: 468 GMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYA 527 Query: 508 PECINFRKFSSRSDVWSYGVTMWEALSYG----QKPYK----------KMKGPEVMAFIE 553 PEC+ KF SDVWS+GVT++E L++ P K +M + +E Sbjct: 528 PECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLE 587 Query: 554 QGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGST 611 +G+R+ P +CP E+Y LM +CW + RP F + ++ ++ K +G S Sbjct: 588 RGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILK----TVHEKYQGQAPSV 641 Score = 164 bits (416), Expect = 9e-41, Method: Composition-based stats. Identities = 80/331 (24%), Positives = 134/331 (40%), Gaps = 45/331 (13%) Query: 315 YESPYSDPEELKDKKLFLKR-DNLLIADI-ELGCGNFGSVRQGVYR-------------- 358 ++ + P L +L R D I + LG G +V +G R Sbjct: 22 FQGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDD 81 Query: 359 --------MRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEA 409 R +++ V +KVL A +M Q+ + ++ + GVC + Sbjct: 82 EDPLVPGRDRGQELRVVLKVLDPSHHDI-ALAFYETASLMSQVSHTHLAFVHGVCVRGPE 140 Query: 410 LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLL 469 ++V E GPL +L +R +P++ + Q++ + YLE KN VH ++ RN+LL Sbjct: 141 NIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILL 200 Query: 470 V-------NRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI--NFRKFSSRS 520 + K+SD G+ +R + W APEC+ S+ Sbjct: 201 ARLGLAEGTSPFIKLSDPGV-------GLGALSREERVERIPWLAPECLPGGANSLSTAM 253 Query: 521 DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKW 580 D W +G T+ E G+ P + E F ++ R+ P CP +L L S C Y+ Sbjct: 254 DKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEP-SCP-QLATLTSQCLTYEP 311 Query: 581 EDRPDFLTVEQRMRACY-YSLASKVEGPPGS 610 RP F T+ + + ++LA + P S Sbjct: 312 TQRPSFRTILRDLTRLQPHNLADVLTVNPDS 342 >3BBT-B nrPDB Length = 328 Score = 292 bits (747), Expect = 3e-79, Method: Composition-based stats. Identities = 106/280 (37%), Positives = 165/280 (58%), Gaps = 6/280 (2%) Query: 322 PEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKK--QIDVAIKVLKQGTEKAD 379 P + + + LK L + LG G FG+V +G++ + +I VAIK+L + T Sbjct: 4 PNQAQLR--ILKETELKRVKV-LGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKA 60 Query: 380 TEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVA 439 E M EA IM +D+P++VRL+GVC + + LV ++ G L +++ ++ I + Sbjct: 61 NVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLL 120 Query: 440 ELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAG 499 Q++ GM YLEE+ VHRDLAARNVL+ + ++ KI+DFGL++ L D+ Y A G Sbjct: 121 NWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNA-DGG 179 Query: 500 KWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRME 559 K P+KW A ECI++RKF+ +SDVWSYGVT+WE +++G KPY + E+ +E+G+R+ Sbjct: 180 KMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLP 239 Query: 560 CPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYS 599 PP C ++Y +M CW+ + RP F + Sbjct: 240 QPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARD 279 >5FM2-A nrPDB Length = 355 Score = 291 bits (745), Expect = 6e-79, Method: Composition-based stats. Identities = 97/299 (32%), Positives = 155/299 (51%), Gaps = 29/299 (9%) Query: 325 LKDKKLFLKRDNLLIADIELGCGNFGSVRQGV---YRMRKKQIDVAIKVLKQGTEKADTE 381 L+D K R NL++ LG G FG V + + R VA+K+LK+ ++ Sbjct: 54 LEDPKWEFPRKNLVLGKT-LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELR 112 Query: 382 EMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIP------ 434 +++ E ++ Q+++P++++L G C + L+L++E A G L FL R+ P Sbjct: 113 DLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSG 172 Query: 435 -----------------VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKI 477 + ++ Q+S GM+YL E VHRDLAARN+L+ KI Sbjct: 173 GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKI 232 Query: 478 SDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQ 537 SDFGLS+ + +DS Y RS G+ P+KW A E + ++++SDVWS+GV +WE ++ G Sbjct: 233 SDFGLSRDVYEEDS-YVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGG 291 Query: 538 KPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRAC 596 PY + + ++ G RME P C E+Y LM CW + + RP F + + + Sbjct: 292 NPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM 350 >4HZS-A nrPDB Length = 341 Score = 291 bits (744), Expect = 7e-79, Method: Composition-based stats. Identities = 101/288 (35%), Positives = 158/288 (54%), Gaps = 15/288 (5%) Query: 332 LKRDNLLIADIELGCGNFGSVRQGVYRM-RKKQIDVAIKVLKQG--TEKADTEEMMREAQ 388 + +L + + +LG G+FG VR+G + K + VA+K LK ++ ++ +RE Sbjct: 9 IGEKDLRLLE-KLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVN 67 Query: 389 IMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMG 448 MH LD+ ++RL GV + +V E+A G L L + + ++ QV+ G Sbjct: 68 AMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEG 127 Query: 449 MKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 M YLE K F+HRDLAARN+LL R KI DFGL +AL +D +Y + K P W AP Sbjct: 128 MGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAP 187 Query: 509 ECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI-EQGKRMECPPECPPE 567 E + R FS SD W +GVT+WE +YGQ+P+ + G +++ I ++G+R+ P +CP + Sbjct: 188 ESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 247 Query: 568 LYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKAE 615 +Y +M CW +K EDRP F+ + + +E P + + Sbjct: 248 IYNVMVQCWAHKPEDRPTFVALRDFL----------LEAQPTDMRALQ 285 >4AT3-A nrPDB Length = 299 Score = 290 bits (743), Expect = 1e-78, Method: Composition-based stats. Identities = 95/284 (33%), Positives = 152/284 (53%), Gaps = 19/284 (6%) Query: 332 LKRDNLLIADIELGCGNFGSVRQGV---YRMRKKQIDVAIKVLKQGTEKADTEEMMREAQ 388 +KR N+++ ELG G FG V + +I VA+K LK ++ A ++ REA+ Sbjct: 10 IKRHNIVL-KRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNA-RKDFHREAE 67 Query: 389 IMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKRE------------EIPV 435 ++ L + +IV+ GVC + + L++V E G L+KFL E+ Sbjct: 68 LLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQ 127 Query: 436 SNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTA 495 S + + Q++ GM YL ++FVHRDLA RN L+ KI DFG+S+ + + D YY Sbjct: 128 SQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTD-YYRV 186 Query: 496 RSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG 555 P++W PE I +RKF++ SDVWS GV +WE +YG++P+ ++ EV+ I QG Sbjct: 187 GGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQG 246 Query: 556 KRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYS 599 + ++ P CP E+Y LM CW + R + + ++ + Sbjct: 247 RVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKA 290 >3CJF-A nrPDB Length = 309 Score = 289 bits (741), Expect = 2e-78, Method: Composition-based stats. Identities = 99/313 (31%), Positives = 149/313 (47%), Gaps = 26/313 (8%) Query: 305 PRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVY---RMRK 361 P +P+D PY K RD L + LG G FG V + Sbjct: 3 PDELPLDEHCERLPYD------ASKWEFPRDRLNLGK-PLGRGAFGQVIEADAFGIDKTA 55 Query: 362 KQIDVAIKVLKQGTEKADTEEMMREAQIM-HQLDNPYIVRLIGVCQAEA--LMLVMEMAG 418 VA+K+LK+G ++ +M E +I+ H + +V L+G C LM+++E Sbjct: 56 TCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCK 115 Query: 419 GGPLHKFLVGKREEI-----------PVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNV 467 G L +L KR E + ++ QV+ GM++L + +HRDLAARN+ Sbjct: 116 FGNLSTYLRSKRNEFVPYKDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNI 175 Query: 468 LLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGV 527 LL ++ KI DFGL++ + D Y + + PLKW APE I R ++ +SDVWS+GV Sbjct: 176 LLSEKNVVKICDFGLARDIYK-DPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGV 234 Query: 528 TMWEALSYGQKPYKKMK-GPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586 +WE S G PY +K E +++G RM P PE+Y M DCW + RP F Sbjct: 235 LLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTF 294 Query: 587 LTVEQRMRACYYS 599 + + + + Sbjct: 295 SELVEHLGNLLQA 307 >1U54-B nrPDB Length = 291 Score = 289 bits (739), Expect = 3e-78, Method: Composition-based stats. Identities = 101/285 (35%), Positives = 157/285 (55%), Gaps = 15/285 (5%) Query: 332 LKRDNLLIADIELGCGNFGSVRQGVYRM-RKKQIDVAIKVLKQG--TEKADTEEMMREAQ 388 + +L + + +LG G+FG VR+G + K + VA+K LK ++ ++ +RE Sbjct: 15 IGEKDLRLLE-KLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVN 73 Query: 389 IMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMG 448 MH LD+ ++RL GV + +V E+A G L L + + ++ QV+ G Sbjct: 74 AMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEG 133 Query: 449 MKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 M YLE K F+HRDLAARN+LL R KI DFGL +AL +D +Y + K P W AP Sbjct: 134 MGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAP 193 Query: 509 ECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI-EQGKRMECPPECPPE 567 E + R FS SD W +GVT+WE +YGQ+P+ + G +++ I ++G+R+ P +CP + Sbjct: 194 ESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 253 Query: 568 LYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQ 612 +Y +M CW +K EDRP F+ + + +E P + Sbjct: 254 IYNVMVQCWAHKPEDRPTFVALRDFL----------LEAQPTDMR 288 >2OGV-A nrPDB Length = 317 Score = 289 bits (739), Expect = 3e-78, Method: Composition-based stats. Identities = 97/293 (33%), Positives = 148/293 (50%), Gaps = 18/293 (6%) Query: 319 YSDPEELK-DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQ---IDVAIKVLKQG 374 + DP +L ++K R+NL LG G FG V + K+ + VA+K+LK Sbjct: 21 FIDPTQLPYNEKWEFPRNNLQFGKT-LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKST 79 Query: 375 TEKADTEEMMREAQIMHQL-DNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKRE- 431 + E +M E +IM L + IV L+G C ++++ E G L FL K E Sbjct: 80 AHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEA 139 Query: 432 --------EIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLS 483 + + ++ QV+ GM +L KN +HRD+AARNVLL N H AKI DFGL+ Sbjct: 140 DLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLA 199 Query: 484 KALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKM 543 + + +DS Y + + P+KW APE I ++ +SDVWSYG+ +WE S G PY + Sbjct: 200 RDI-MNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGI 258 Query: 544 -KGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRA 595 + ++ G +M P P +Y++M CW + RP F + ++ Sbjct: 259 LVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQE 311 >3BEA-A nrPDB Length = 333 Score = 288 bits (737), Expect = 5e-78, Method: Composition-based stats. Identities = 96/297 (32%), Positives = 146/297 (49%), Gaps = 22/297 (7%) Query: 319 YSDPEELK-DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQ---IDVAIKVLKQG 374 + DP +L ++K R+NL LG G FG V + K+ + VA+K+LK Sbjct: 29 FIDPTQLPYNEKWEFPRNNLQFGKT-LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKST 87 Query: 375 TEKADTEEMMREAQIMHQL-DNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKR-- 430 + E +M E +IM L + IV L+G C ++++ E G L FL K Sbjct: 88 AHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRV 147 Query: 431 -----------EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISD 479 + ++ QV+ GM +L KN +HRD+AARNVLL N H AKI D Sbjct: 148 LETDPAFAIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGD 207 Query: 480 FGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKP 539 FGL++ + +DS Y + + P+KW APE I ++ +SDVWSYG+ +WE S G P Sbjct: 208 FGLARDI-MNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNP 266 Query: 540 YKKM-KGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRA 595 Y + + ++ G +M P P +Y++M CW + RP F + ++ Sbjct: 267 YPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQE 323 >3KRL-A nrPDB Length = 335 Score = 286 bits (733), Expect = 1e-77, Method: Composition-based stats. Identities = 98/299 (32%), Positives = 149/299 (49%), Gaps = 24/299 (8%) Query: 319 YSDPEELK-DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQ---IDVAIKVLKQG 374 + DP +L ++K R+NL LG G FG V + K+ + VA+K+LK Sbjct: 29 FIDPTQLPYNEKWEFPRNNLQFGKT-LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKST 87 Query: 375 TEKADTEEMMREAQIMHQL-DNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKR-- 430 + E +M E +IM L + IV L+G C ++++ E G L FL KR Sbjct: 88 AHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPP 147 Query: 431 -------------EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKI 477 E++ ++ QV+ GM +L KN +HRD+AARNVLL N H AKI Sbjct: 148 GLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKI 207 Query: 478 SDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQ 537 DFGL++ + +DS Y + + P+KW APE I ++ +SDVWSYG+ +WE S G Sbjct: 208 GDFGLARDI-MNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGL 266 Query: 538 KPYKKM-KGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRA 595 PY + + ++ G +M P P +Y++M CW + RP F + ++ Sbjct: 267 NPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQE 325 >3V5Q-A nrPDB Length = 297 Score = 286 bits (733), Expect = 1e-77, Method: Composition-based stats. Identities = 94/287 (32%), Positives = 151/287 (52%), Gaps = 21/287 (7%) Query: 329 KLFLKRDNLLIADIELGCGNFGSVRQGV---YRMRKKQIDVAIKVLKQGTEKADTEEMMR 385 + + ++ ELG G FG V K ++ VA+K LK T A ++ R Sbjct: 8 HVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTL-AARKDFQR 66 Query: 386 EAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGK--------------- 429 EA+++ L + +IV+ GVC + L++V E G L+KFL Sbjct: 67 EAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQA 126 Query: 430 REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD 489 + E+ +S + + Q++ GM YL ++FVHRDLA RN L+ KI DFG+S+ + + Sbjct: 127 KGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYST 186 Query: 490 DSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVM 549 D YY P++W PE I +RKF++ SDVWS+GV +WE +YG++P+ ++ EV+ Sbjct: 187 D-YYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVI 245 Query: 550 AFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRAC 596 I QG+ +E P CP E+Y +M CW + + R + + + + A Sbjct: 246 ECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHAL 292 >3I81-A nrPDB Length = 315 Score = 286 bits (733), Expect = 2e-77, Method: Composition-based stats. Identities = 98/320 (30%), Positives = 163/320 (50%), Gaps = 32/320 (10%) Query: 312 TSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKK---QIDVAI 368 S + D E+ +K+ + R ELG G+FG V +GV + K + VAI Sbjct: 2 VSAADVYVPDEWEVAREKITMSR--------ELGQGSFGMVYEGVAKGVVKDEPETRVAI 53 Query: 369 KVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLV 427 K + + + E + EA +M + + ++VRL+GV Q + +++ME+ G L +L Sbjct: 54 KTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLR 113 Query: 428 GKREEI---------PVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKIS 478 R E+ +S + ++ +++ GM YL FVHRDLAARN ++ KI Sbjct: 114 SLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIG 173 Query: 479 DFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQK 538 DFG+++ + D YY G P++W +PE + F++ SDVWS+GV +WE + ++ Sbjct: 174 DFGMTRDIYETD-YYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQ 232 Query: 539 PYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRA--- 595 PY+ + +V+ F+ +G ++ P CP L+ LM CW Y + RP FL + ++ Sbjct: 233 PYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEME 292 Query: 596 -------CYYSLASKVEGPP 608 YYS +K+E P Sbjct: 293 PGFREVSFYYSEENKMENNP 312 >5KMM-A nrPDB Length = 329 Score = 286 bits (733), Expect = 2e-77, Method: Composition-based stats. Identities = 97/300 (32%), Positives = 155/300 (51%), Gaps = 20/300 (6%) Query: 318 PYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYR---MRKKQIDVAIKVLKQG 374 +P+ D + + ++ ELG G FG V + ++ VA+K LK+ Sbjct: 17 IIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEA 76 Query: 375 TEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEI 433 +E A ++ REA+++ L + +IVR GVC + L++V E G L++FL + Sbjct: 77 SESA-RQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDA 135 Query: 434 PV--------------SNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISD 479 + + + QV+ GM YL +FVHRDLA RN L+ KI D Sbjct: 136 KLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGD 195 Query: 480 FGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKP 539 FG+S+ + + D YY P++W PE I +RKF++ SDVWS+GV +WE +YG++P Sbjct: 196 FGMSRDIYSTD-YYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQP 254 Query: 540 YKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYS 599 + ++ E + I QG+ +E P CPPE+YA+M CW + + R V R++A + Sbjct: 255 WYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQA 314 >3PP0-A nrPDB Length = 338 Score = 284 bits (728), Expect = 6e-77, Method: Composition-based stats. Identities = 99/271 (36%), Positives = 155/271 (57%), Gaps = 4/271 (1%) Query: 331 FLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADTEEMMREAQ 388 LK L + LG G FG+V +G++ + + VAIKVL++ T +E++ EA Sbjct: 13 ILKETELRKVKV-LGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAY 71 Query: 389 IMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMG 448 +M + +PY+ RL+G+C + LV ++ G L + R + ++ Q++ G Sbjct: 72 VMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKG 131 Query: 449 MKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 M YLE+ VHRDLAARNVL+ + ++ KI+DFGL++ L D++ Y A GK P+KW A Sbjct: 132 MSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHA-DGGKVPIKWMAL 190 Query: 509 ECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPEL 568 E I R+F+ +SDVWSYGVT+WE +++G KPY + E+ +E+G+R+ PP C ++ Sbjct: 191 ESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDV 250 Query: 569 YALMSDCWIYKWEDRPDFLTVEQRMRACYYS 599 Y +M CW+ E RP F + Sbjct: 251 YMIMVKCWMIDSECRPRFRELVSEFSRMARD 281 >3ZBF-A nrPDB Length = 322 Score = 284 bits (728), Expect = 6e-77, Method: Composition-based stats. Identities = 93/289 (32%), Positives = 161/289 (55%), Gaps = 18/289 (6%) Query: 332 LKRDNLLIADIELGCGNFGSVRQG----VYRMRKKQIDVAIKVLKQGTEKADTEEMMREA 387 R+ L + + LG G FG V +G + + +I VA+K LK+G+ + E ++EA Sbjct: 30 FPREKLTL-RLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEA 88 Query: 388 QIMHQLDNPYIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVGKR------EEIPVSNVAE 440 +M + ++P I++ +GVC E +++E+ GG L +L R + + ++ + Sbjct: 89 HLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVD 148 Query: 441 LLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHY-----AKISDFGLSKALGADDSYYTA 495 L +S G YLE +F+HRDLAARN L+ + Y KI DFGL++ + +D YY Sbjct: 149 LCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKND-YYRK 207 Query: 496 RSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG 555 R G P++W APE + F+++SDVWS+G+ +WE L+ G +PY +V+ +++ G Sbjct: 208 RGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTG 267 Query: 556 KRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKV 604 R+E P CP +L+ LM+ CW + + RP F ++ +++ + + Sbjct: 268 GRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSI 316 >5H2U-A nrPDB Length = 267 Score = 284 bits (727), Expect = 7e-77, Method: Composition-based stats. Identities = 91/266 (34%), Positives = 144/266 (54%), Gaps = 10/266 (3%) Query: 333 KRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQ 392 R+ + +LG G FG V +G+++ R + VAIKV+ + + + E Q M + Sbjct: 4 PREEFTLCR-KLGSGYFGEVFEGLWKDR---VQVAIKVISRDNL-LHQQMLQSEIQAMKK 58 Query: 393 LDNPYIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVGKREEI-PVSNVAELLHQVSMGMK 450 L + +I+ L V + + ++ E+ G L + L E++ PVS + ++ QV+ GM Sbjct: 59 LRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMC 118 Query: 451 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510 YLE +N++HRDLAARN+L+ K+ DFGL++ + D P KW APE Sbjct: 119 YLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKED---VYLSHDHNIPYKWTAPEA 175 Query: 511 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYA 570 ++ +S++SDVWS+G+ + E S GQ PY M E ++ G RM CP ECPP ++ Sbjct: 176 LSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHK 235 Query: 571 LMSDCWIYKWEDRPDFLTVEQRMRAC 596 LM CW E RP F + +R+ + Sbjct: 236 LMLTCWCRDPEQRPTFKALRERLSSF 261 >5GNK-A nrPDB Length = 297 Score = 284 bits (727), Expect = 8e-77, Method: Composition-based stats. Identities = 98/271 (36%), Positives = 157/271 (57%), Gaps = 4/271 (1%) Query: 331 FLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADTEEMMREAQ 388 LK + LG G FG+V +G++ +++ VAIK L++ T +E++ EA Sbjct: 15 ILKETEFKKIKV-LGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAY 73 Query: 389 IMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMG 448 +M +DNP++ RL+G+C + L+M++ G L ++ ++ I + Q++ G Sbjct: 74 VMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKG 133 Query: 449 MKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 M YLE++ VHRDLAARNVL+ + KI+DFGL+K LGA++ Y A GK P+KW A Sbjct: 134 MNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAE-GGKVPIKWMAL 192 Query: 509 ECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPEL 568 E I R ++ +SDVWSYGVT+WE +++G KPY + E+ + +E+G+R+ PP C ++ Sbjct: 193 ESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDV 252 Query: 569 YALMSDCWIYKWEDRPDFLTVEQRMRACYYS 599 Y +M CW+ + RP F + Sbjct: 253 YMIMVKCWMIDADSRPKFRELIIEFSKMARD 283 >4R7H-A nrPDB Length = 343 Score = 284 bits (727), Expect = 8e-77, Method: Composition-based stats. Identities = 97/306 (31%), Positives = 148/306 (48%), Gaps = 31/306 (10%) Query: 319 YSDPEELK-DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQ---IDVAIKVLKQG 374 + DP +L ++K R+NL LG G FG V + K+ + VA+K+LK Sbjct: 33 FIDPTQLPYNEKWEFPRNNLQFGKT-LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKST 91 Query: 375 TEKADTEEMMREAQIMHQL-DNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREE 432 + E +M E +IM L + IV L+G C ++++ E G L FL K E Sbjct: 92 AHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEA 151 Query: 433 I----------------------PVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLV 470 + + ++ QV+ GM +L KN +HRD+AARNVLL Sbjct: 152 MLGPSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLT 211 Query: 471 NRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMW 530 N H AKI DFGL++ + +DS Y + + P+KW APE I ++ +SDVWSYG+ +W Sbjct: 212 NGHVAKIGDFGLARDI-MNDSNYIVKGNARLPVKWMAPESIFDSVYTVQSDVWSYGILLW 270 Query: 531 EALSYGQKPYKKM-KGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTV 589 E S G PY + + ++ G +M P P +Y++M CW + RP F + Sbjct: 271 EIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 330 Query: 590 EQRMRA 595 ++ Sbjct: 331 TSFLQE 336 >3G0E-A nrPDB Length = 336 Score = 284 bits (726), Expect = 8e-77, Method: Composition-based stats. Identities = 99/300 (33%), Positives = 142/300 (47%), Gaps = 26/300 (8%) Query: 319 YSDPEELK-DKKLFLKRDNLLIADIELGCGNFGSVRQGV---YRMRKKQIDVAIKVLKQG 374 Y DP +L D K R+ L LG G FG V + + VA+K+LK Sbjct: 29 YIDPTQLPYDHKWEFPRNRLSFGKT-LGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPS 87 Query: 375 TEKADTEEMMREAQIMHQL-DNPYIVRLIGVCQAEALMLV-MEMAGGGPLHKFLVGKRE- 431 + E +M E +++ L ++ IV L+G C LV E G L FL KR+ Sbjct: 88 AHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDS 147 Query: 432 ----------------EIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYA 475 + + ++ +QV+ GM +L KN +HRDLAARN+LL + Sbjct: 148 FICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRIT 207 Query: 476 KISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSY 535 KI DFGL++ + +DS Y + + P+KW APE I ++ SDVWSYG+ +WE S Sbjct: 208 KICDFGLARDI-KNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSL 266 Query: 536 GQKPYKKMK-GPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMR 594 G PY M + I++G RM P P E+Y +M CW RP F + Q + Sbjct: 267 GSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIE 326 >3LZB-A nrPDB Length = 327 Score = 283 bits (724), Expect = 2e-76, Method: Composition-based stats. Identities = 97/271 (35%), Positives = 156/271 (57%), Gaps = 4/271 (1%) Query: 331 FLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADTEEMMREAQ 388 LK + LG G FG+V +G++ +++ VAIK L++ T +E++ EA Sbjct: 11 ILKETEFKKIKV-LGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAY 69 Query: 389 IMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMG 448 +M +DNP++ RL+G+C + L+ ++ G L ++ ++ I + Q++ G Sbjct: 70 VMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKG 129 Query: 449 MKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 M YLE++ VHRDLAARNVL+ + KI+DFGL+K LGA++ Y A GK P+KW A Sbjct: 130 MNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAE-GGKVPIKWMAL 188 Query: 509 ECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPEL 568 E I R ++ +SDVWSYGVT+WE +++G KPY + E+ + +E+G+R+ PP C ++ Sbjct: 189 ESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDV 248 Query: 569 YALMSDCWIYKWEDRPDFLTVEQRMRACYYS 599 Y +M CW+ + RP F + Sbjct: 249 YMIMRKCWMIDADSRPKFRELIIEFSKMARD 279 >5X02-A nrPDB Length = 347 Score = 282 bits (722), Expect = 3e-76, Method: Composition-based stats. Identities = 99/307 (32%), Positives = 146/307 (47%), Gaps = 31/307 (10%) Query: 316 ESPYSDPEELK-DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRM---RKKQIDVAIKVL 371 E Y D E + D K R+NL + LG G FG V I VA+K+L Sbjct: 28 EYFYVDFREYEYDLKWEFPRENLEFGKV-LGSGAFGKVMNATAYGISKTGVSIQVAVKML 86 Query: 372 KQGTEKADTEEMMREAQIMHQL-DNPYIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVGK 429 K+ + ++ E +M E ++M QL + IV L+G C + + L+ E G L +L K Sbjct: 87 KEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSK 146 Query: 430 REEIPVSNVAE----------------------LLHQVSMGMKYLEEKNFVHRDLAARNV 467 RE+ + +QV+ GM++LE K+ VHRDLAARNV Sbjct: 147 REKFSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNV 206 Query: 468 LLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGV 527 L+ + KI DFGL++ + DS Y R + P+KW APE + ++ +SDVWSYG+ Sbjct: 207 LVTHGKVVKICDFGLARDI-MSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGI 265 Query: 528 TMWEALSYGQKPYKKMK-GPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586 +WE S G PY + I+ G +M+ P E+Y +M CW + RP F Sbjct: 266 LLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSF 325 Query: 587 LTVEQRM 593 + + Sbjct: 326 PNLTSFL 332 >1FVR-A nrPDB Length = 327 Score = 282 bits (722), Expect = 3e-76, Method: Composition-based stats. Identities = 95/292 (32%), Positives = 145/292 (49%), Gaps = 26/292 (8%) Query: 320 SDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKAD 379 DP +++ D+ +G GNFG V + + ++D AIK +K+ K D Sbjct: 14 PDPTIYPVLDW----NDIKFQDV-IGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDD 68 Query: 380 TEEMMREAQIMHQL-DNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKR------- 430 + E +++ +L +P I+ L+G C+ L L +E A G L FL R Sbjct: 69 HRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPA 128 Query: 431 --------EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGL 482 + + V+ GM YL +K F+HRDLAARN+L+ + AKI+DFGL Sbjct: 129 FAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGL 188 Query: 483 SKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKK 542 S+ Y ++ G+ P++W A E +N+ +++ SDVWSYGV +WE +S G PY Sbjct: 189 SR----GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCG 244 Query: 543 MKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMR 594 M E+ + QG R+E P C E+Y LM CW K +RP F + + Sbjct: 245 MTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLN 296 >3QGY-A nrPDB Length = 286 Score = 282 bits (722), Expect = 3e-76, Method: Composition-based stats. Identities = 95/259 (36%), Positives = 144/259 (55%), Gaps = 8/259 (3%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 E+G G FG V G + + K VAIK +K+G+ D + + EA++M +L +P +V+L Sbjct: 33 QEIGSGQFGLVHLGYWLNKDK---VAIKTIKEGSMSED--DFIEEAEVMMKLSHPKLVQL 87 Query: 402 IGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 GVC + + LV E G L +L +R + + V GM YLEE +HR Sbjct: 88 YGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHR 147 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRS 520 DLAARN L+ K+SDFG+++ + D YT+ + K+P+KW +PE +F ++SS+S Sbjct: 148 DLAARNCLVGENQVIKVSDFGMTRFVLDDQ--YTSSTGTKFPVKWASPEVFSFSRYSSKS 205 Query: 521 DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKW 580 DVWS+GV MWE S G+ PY+ EV+ I G R+ P +Y +M+ CW + Sbjct: 206 DVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERP 265 Query: 581 EDRPDFLTVEQRMRACYYS 599 EDRP F + +++ S Sbjct: 266 EDRPAFSRLLRQLAEIAES 284 >1BYG-A nrPDB Length = 278 Score = 282 bits (721), Expect = 4e-76, Method: Composition-based stats. Identities = 97/276 (35%), Positives = 147/276 (53%), Gaps = 17/276 (6%) Query: 324 ELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEM 383 E L L + +G G FG V G YR K VA+K +K + Sbjct: 10 EFYRSGWALNMKELKLLQT-IGKGEFGDVMLGDYRGNK----VAVKCIKNDAT---AQAF 61 Query: 384 MREAQIMHQLDNPYIVRLIGVC--QAEALMLVMEMAGGGPLHKFLVGK-REEIPVSNVAE 440 + EA +M QL + +V+L+GV + L +V E G L +L + R + + + Sbjct: 62 LAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLK 121 Query: 441 LLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK 500 V M+YLE NFVHRDLAARNVL+ + AK+SDFGL+K + + GK Sbjct: 122 FSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS------STQDTGK 175 Query: 501 WPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMEC 560 P+KW APE + +KFS++SDVWS+G+ +WE S+G+ PY ++ +V+ +E+G +M+ Sbjct: 176 LPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDA 235 Query: 561 PPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRAC 596 P CPP +Y +M +CW RP FL + +++ Sbjct: 236 PDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHI 271 >5U6B-A nrPDB Length = 307 Score = 281 bits (720), Expect = 5e-76, Method: Composition-based stats. Identities = 99/288 (34%), Positives = 157/288 (54%), Gaps = 15/288 (5%) Query: 326 KDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT-EKADTEEMM 384 K + + + R + + LG G FG+V +G + VA+K +K +++ E+ + Sbjct: 14 KLRDVMVDRHKVALGKT-LGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFL 72 Query: 385 REAQIMHQLDNPYIVRLIGVC----QAEAL---MLVMEMAGGGPLHKFLVGKRE-----E 432 EA M + D+P ++RLIGVC + E+ ++++ G LH FL+ R Sbjct: 73 SEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVY 132 Query: 433 IPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSY 492 +P + + + ++ GM+YL K F+HRDLAARN +L ++DFGLSK + D Y Sbjct: 133 LPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGD-Y 191 Query: 493 YTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI 552 Y K P+KW A E + R ++S+SDVWS+GVTMWE + GQ PY ++ E+ ++ Sbjct: 192 YRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYL 251 Query: 553 EQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL 600 QG R++ P +C LYALMS CW +DRP F + + + +L Sbjct: 252 RQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKAL 299 >5HLW-A nrPDB Length = 299 Score = 281 bits (720), Expect = 5e-76, Method: Composition-based stats. Identities = 87/268 (32%), Positives = 144/268 (53%), Gaps = 4/268 (1%) Query: 340 ADIELGCGNFGSVRQGVY-RMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYI 398 + +G G+FG V G K+I A+K L + T+ + + + E IM +P + Sbjct: 24 FNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNV 83 Query: 399 VRLIGVCQAE--ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 + L+G+C + ++V+ G L F+ + V ++ QV+ GMKYL K Sbjct: 84 LSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKK 143 Query: 457 FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYT-ARSAGKWPLKWYAPECINFRK 515 FVHRDLAARN +L + K++DFGL++ + + Y ++ K P+KW A E + +K Sbjct: 144 FVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQTQK 203 Query: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDC 575 F+++SDVWS+GV +WE ++ G PY + ++ ++ QG+R+ P CP LY +M C Sbjct: 204 FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKC 263 Query: 576 WIYKWEDRPDFLTVEQRMRACYYSLASK 603 W K E RP F + R+ A + + + Sbjct: 264 WHPKAEMRPSFSELVSRISAIFSTFIGE 291 >3C1X-A nrPDB Length = 373 Score = 281 bits (720), Expect = 5e-76, Method: Composition-based stats. Identities = 88/302 (29%), Positives = 153/302 (50%), Gaps = 6/302 (1%) Query: 308 MPMDTSVYESPYSDPE--ELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVY-RMRKKQI 364 +T + +PE + + ++ + +G G+FG V G K+I Sbjct: 59 QGANTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKI 118 Query: 365 DVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAE--ALMLVMEMAGGGPL 422 A+K L + T+ + + + E IM +P ++ L+G+C + ++V+ G L Sbjct: 119 HCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDL 178 Query: 423 HKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGL 482 F+ + V ++ QV+ GMK+L K FVHRDLAARN +L + K++DFGL Sbjct: 179 RNFIRNETHNPTVKDLIGFGLQVAKGMKFLASKKFVHRDLAARNCMLDEKFTVKVADFGL 238 Query: 483 SKALGADD-SYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYK 541 ++ + + ++ K P+KW A E + +KF+++SDVWS+GV +WE ++ G PY Sbjct: 239 ARDMYDKEFDSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYP 298 Query: 542 KMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLA 601 + ++ ++ QG+R+ P CP LY +M CW K E RP F + R+ A + + Sbjct: 299 DVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFI 358 Query: 602 SK 603 + Sbjct: 359 GE 360 >4XUF-A nrPDB Length = 297 Score = 281 bits (720), Expect = 5e-76, Method: Composition-based stats. Identities = 95/295 (32%), Positives = 141/295 (47%), Gaps = 30/295 (10%) Query: 327 DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRM---RKKQIDVAIKVLKQGTEKADTEEM 383 D K R+NL + LG G FG V I VA+K+LK+ + ++ E + Sbjct: 1 DLKWEFPRENLEFGKV-LGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREAL 59 Query: 384 MREAQIMHQL-DNPYIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAE- 440 M E ++M QL + IV L+G C + + L+ E G L +L KRE+ + Sbjct: 60 MSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYE 119 Query: 441 ---------------------LLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISD 479 +QV+ GM++LE K+ VHRDLAARNVL+ + KI D Sbjct: 120 NQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICD 179 Query: 480 FGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKP 539 FGL++ + DS Y R + P+KW APE + ++ +SDVWSYG+ +WE S G P Sbjct: 180 FGLARDI-MSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNP 238 Query: 540 YKKMK-GPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRM 593 Y + I+ G +M+ P E+Y +M CW + RP F + + Sbjct: 239 YPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 293 >1LUF-A nrPDB Length = 343 Score = 280 bits (717), Expect = 1e-75, Method: Composition-based stats. Identities = 99/301 (32%), Positives = 145/301 (48%), Gaps = 29/301 (9%) Query: 331 FLKRDNLLIADIELGCGNFGSVRQGVYRMR---KKQIDVAIKVLKQGTEKADTEEMMREA 387 R+N+ ++G G FG V Q + VA+K+LK+ + REA Sbjct: 43 EYPRNNIEYVR-DIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREA 101 Query: 388 QIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEI------------- 433 +M + DNP IV+L+GVC + + L+ E G L++FL Sbjct: 102 ALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRA 161 Query: 434 ----------PVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLS 483 + + QV+ GM YL E+ FVHRDLA RN L+ KI+DFGLS Sbjct: 162 RVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLS 221 Query: 484 KALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKM 543 + + + D YY A P++W PE I + ++++ SDVW+YGV +WE SYG +PY M Sbjct: 222 RNIYSAD-YYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGM 280 Query: 544 KGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASK 603 EV+ ++ G + CP CP ELY LM CW DRP F ++ + ++ Sbjct: 281 AHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRILQRMCERAEGT 340 Query: 604 V 604 V Sbjct: 341 V 341 >3SXS-A nrPDB Length = 268 Score = 280 bits (716), Expect = 1e-75, Method: Composition-based stats. Identities = 96/271 (35%), Positives = 147/271 (54%), Gaps = 9/271 (3%) Query: 329 KLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQ 388 + LKR+ + + ELG G FG V+ G ++ Q DVA+K++K+G+ D E +EAQ Sbjct: 2 HMELKREEITLLK-ELGSGQFGVVKLGKWKG---QYDVAVKMIKEGSMSED--EFFQEAQ 55 Query: 389 IMHQLDNPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSM 447 M +L +P +V+ GVC E + +V E G L +L + + S + E+ + V Sbjct: 56 TMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCE 115 Query: 448 GMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYA 507 GM +LE F+HRDLAARN L+ K+SDFG+++ + D Y + K+P+KW A Sbjct: 116 GMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQ--YVSSVGTKFPVKWSA 173 Query: 508 PECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPE 567 PE ++ K+SS+SDVW++G+ MWE S G+ PY EV+ + QG R+ P Sbjct: 174 PEVFHYFKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDT 233 Query: 568 LYALMSDCWIYKWEDRPDFLTVEQRMRACYY 598 +Y +M CW E RP F + + Sbjct: 234 IYQIMYSCWHELPEKRPTFQQLLSSIEPLRE 264 >5GRN-A nrPDB Length = 356 Score = 279 bits (715), Expect = 2e-75, Method: Composition-based stats. Identities = 100/314 (31%), Positives = 149/314 (47%), Gaps = 34/314 (10%) Query: 315 YESPYSDPEELK-DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQ---IDVAIKV 370 +E Y DP +L D + RD L++ + LG G FG V +G + + VA+K+ Sbjct: 25 HEYIYVDPMQLPYDSRWEFPRDGLVLGRV-LGSGAFGKVVEGTAYGLSRSQPVMKVAVKM 83 Query: 371 LKQGTEKADTEEMMREAQIMHQLD-NPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVG 428 LK ++ + +M E +IM L + IV L+G C + ++ E G L +L Sbjct: 84 LKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHK 143 Query: 429 KR-------------------------EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLA 463 R E + + ++ +QV+ GM++L KN VHRDLA Sbjct: 144 NRDSFLSHKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLA 203 Query: 464 ARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVW 523 ARNVLL KI DFGL++ + DS Y ++ + P+KW APE I +++ SDVW Sbjct: 204 ARNVLLAQGKIVKICDFGLARDI-MHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVW 262 Query: 524 SYGVTMWEALSYGQKPYKK-MKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWED 582 SYG+ +WE S G PY M I+ G RM P E+Y +M CW + E Sbjct: 263 SYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEK 322 Query: 583 RPDFLTVEQRMRAC 596 RP F + + + Sbjct: 323 RPSFYHLSEIVENL 336 >4XLV-A nrPDB Length = 328 Score = 279 bits (715), Expect = 2e-75, Method: Composition-based stats. Identities = 95/334 (28%), Positives = 159/334 (47%), Gaps = 33/334 (9%) Query: 294 PEPARITSPDKPRPMPMDTSVYESPY-SDPEELKDKKLFLKRDNLLIADIELGCGNFGSV 352 + + P + S Y D E+ +K+ L R ELG G+FG V Sbjct: 4 GPLGPLFASSNPEYLSASDVFPSSVYVPDEWEVSREKITLLR--------ELGQGSFGMV 55 Query: 353 RQGVYRMRKK---QIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAE 408 +G R K + VA+K + + + E + EA +M ++VRL+GV + + Sbjct: 56 YEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQ 115 Query: 409 ALMLVMEMAGGGPLHKFLVGKREE---------IPVSNVAELLHQVSMGMKYLEEKNFVH 459 ++VME+ G L +L R E + + ++ +++ GM YL K FVH Sbjct: 116 PTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVH 175 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 519 RDLAARN ++ + KI DFG+++ + D YY G P++W APE + F++ Sbjct: 176 RDLAARNCMVAHDFTVKIGDFGMTRDIYETD-YYRKGGKGLLPVRWMAPESLKDGVFTTS 234 Query: 520 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYK 579 SD+WS+GV +WE S ++PY+ + +V+ F+ G ++ P CP + LM CW + Sbjct: 235 SDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFN 294 Query: 580 WEDRPDFLTVEQRMR----------ACYYSLASK 603 RP FL + ++ + ++S +K Sbjct: 295 PNMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENK 328 >6DBM-A nrPDB Length = 318 Score = 279 bits (713), Expect = 3e-75, Method: Composition-based stats. Identities = 103/303 (33%), Positives = 147/303 (48%), Gaps = 27/303 (8%) Query: 327 DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADTEEMM 384 D +F KR I D LG G+FG V Y VA+K LK Sbjct: 24 DPTVFHKRYLKKIRD--LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWK 81 Query: 385 REAQIMHQLDNPYIVRLIGVCQAEA---LMLVMEMAGGGPLHKFLVGKREEIPVSNVAEL 441 +E I+ L + +I++ G C+ L LVME G L +L R I ++ + Sbjct: 82 QEIDILRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYL--PRHSIGLAQLLLF 139 Query: 442 LHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKW 501 Q+ GM YL ++++HRDLAARNVLL N KI DFGL+KA+ YY R G Sbjct: 140 AQQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDS 199 Query: 502 PLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYG----QKPYK----------KMKGPE 547 P+ WYAPEC+ KF SDVWS+GVT++E L++ P K +M Sbjct: 200 PVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLR 259 Query: 548 VMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGP 607 + +E+G+R+ P +CP E+Y LM +CW + RP F + ++ ++ K +G Sbjct: 260 LTELLERGERLPRPDKCPAEVYHLMKNCWETEASFRPTFENLIPILK----TVHEKYQGQ 315 Query: 608 PGS 610 S Sbjct: 316 APS 318 >6E4F-A nrPDB Length = 290 Score = 278 bits (712), Expect = 4e-75, Method: Composition-based stats. Identities = 103/278 (37%), Positives = 153/278 (55%), Gaps = 21/278 (7%) Query: 315 YESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG 374 Y S DP++L FLK ELG G FG V+ G +R Q DVAIK++K+G Sbjct: 23 YGSWEIDPKDL----TFLK---------ELGTGQFGVVKYGKWRG---QYDVAIKMIKEG 66 Query: 375 TEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEI 433 + D E + EA++M L + +V+L GVC + + ++ E G L +L R Sbjct: 67 SMSED--EFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRF 124 Query: 434 PVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYY 493 + E+ V M+YLE K F+HRDLAARN L+ ++ K+SDFGLS+ + D+ Y Sbjct: 125 QTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDE--Y 182 Query: 494 TARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIE 553 T+ K+P++W PE + + KFSS+SD+W++GV MWE S G+ PY++ E I Sbjct: 183 TSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIA 242 Query: 554 QGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQ 591 QG R+ P ++Y +M CW K ++RP F + Sbjct: 243 QGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLS 280 >4Y93-A nrPDB Length = 446 Score = 278 bits (712), Expect = 4e-75, Method: Composition-based stats. Identities = 103/278 (37%), Positives = 155/278 (55%), Gaps = 21/278 (7%) Query: 315 YESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG 374 Y S DP++L FLK ELG G FG V+ G +R Q DVAIK++K+G Sbjct: 180 YGSWEIDPKDL----TFLK---------ELGTGQFGVVKYGKWRG---QYDVAIKMIKEG 223 Query: 375 TEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEI 433 + D E + EA++M L + +V+L GVC + + ++ E G L +L R Sbjct: 224 SMSED--EFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRF 281 Query: 434 PVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYY 493 + E+ V M+YLE K F+HRDLAARN L+ ++ K+SDFG+++ + D+ Y Sbjct: 282 QTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDE--Y 339 Query: 494 TARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIE 553 T+ + K+P+KW +PE + + KFSS+SD+W++GV MWE S G+ PY++ E I Sbjct: 340 TSSTGSKFPVKWASPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIA 399 Query: 554 QGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQ 591 QG R+ P +YA+M CW K ++RP F + Sbjct: 400 QGLRLPRPHLASERVYAIMYSCWHEKADERPTFKILLS 437 >4E20-A nrPDB Length = 290 Score = 278 bits (710), Expect = 7e-75, Method: Composition-based stats. Identities = 102/288 (35%), Positives = 144/288 (50%), Gaps = 23/288 (7%) Query: 327 DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADTEEMM 384 D +F KR I D LG G+FG V Y VA+K LK+G Sbjct: 1 DPTVFHKRYLKKIRD--LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQ 58 Query: 385 REAQIMHQLDNPYIVRLIGVCQAEA---LMLVMEMAGGGPLHKFLVGKREEIPVSNVAEL 441 RE +I+ L + +IV+ G C+ + + LVME G L +L R + ++ + Sbjct: 59 REIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYL--PRHCVGLAQLLLF 116 Query: 442 LHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKW 501 Q+ GM YL ++++HR LAARNVLL N KI DFGL+KA+ YY R G Sbjct: 117 AQQICEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDS 176 Query: 502 PLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYG---QKPYKK-----------MKGPE 547 P+ WYAPEC+ KF SDVWS+GVT++E L+Y Q P+ K M Sbjct: 177 PVFWYAPECLKECKFYYASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVLR 236 Query: 548 VMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRA 595 + +E+G+R+ P CP E+Y LM +CW + RP F + ++ Sbjct: 237 LTELLERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNLVPILQT 284 >5U6C-A nrPDB Length = 315 Score = 276 bits (707), Expect = 1e-74, Method: Composition-based stats. Identities = 100/301 (33%), Positives = 163/301 (54%), Gaps = 17/301 (5%) Query: 317 SPYSDPEELKDK--KLFLKRDNLLIADIELGCGNFGSVRQGVYRMR-KKQIDVAIKVLKQ 373 + EEL++K + + R+ L++ I LG G FGSV +G + + VA+K +K Sbjct: 16 LYFQGSEELQNKLEDVVIDRNLLILGKI-LGEGEFGSVMEGNLKQEDGTSLKVAVKTMKL 74 Query: 374 G-TEKADTEEMMREAQIMHQLDNPYIVRLIGVCQA------EALMLVMEMAGGGPLHKFL 426 + + + EE + EA M +P ++RL+GVC M+++ G LH +L Sbjct: 75 DNSSQREIEEFLSEAACMKDFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYL 134 Query: 427 VGKR-----EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFG 481 + R + IP+ + + + +++GM+YL +NF+HRDLAARN +L + ++DFG Sbjct: 135 LYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFG 194 Query: 482 LSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYK 541 LSK + + D YY K P+KW A E + R ++S+SDVW++GVTMWE + G PY Sbjct: 195 LSKKIYSGD-YYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYP 253 Query: 542 KMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLA 601 ++ E+ ++ G R++ P +C ELY +M CW DRP F + ++ SL Sbjct: 254 GVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLP 313 Query: 602 S 602 Sbjct: 314 D 314 >4LRM-A nrPDB Length = 334 Score = 276 bits (707), Expect = 2e-74, Method: Composition-based stats. Identities = 97/274 (35%), Positives = 156/274 (56%), Gaps = 7/274 (2%) Query: 331 FLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADTEEMMREAQ 388 LK + LG G FG+V +G++ +++ VAIK L++ T +E++ EA Sbjct: 15 ILKETEFKKIKV-LGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAY 73 Query: 389 IMHQLDNP---YIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQV 445 +M +DNP ++ RL+G+C + L+ ++ G L ++ ++ I + Q+ Sbjct: 74 VMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQI 133 Query: 446 SMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKW 505 + GM YLE++ VHRDLAARNVL+ + KI+DFGL+K LGA++ Y A GK P+KW Sbjct: 134 AKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAE-GGKVPIKW 192 Query: 506 YAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP 565 A E I R ++ +SDVWSYGVT+WE +++G KPY + E+ + +E+G+R+ PP C Sbjct: 193 MALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICT 252 Query: 566 PELYALMSDCWIYKWEDRPDFLTVEQRMRACYYS 599 ++Y +M CW+ + RP F + Sbjct: 253 IDVYMIMVKCWMIDADSRPKFRELIIEFSKMARD 286 >3QUP-A nrPDB Length = 323 Score = 275 bits (703), Expect = 5e-74, Method: Composition-based stats. Identities = 97/297 (32%), Positives = 155/297 (52%), Gaps = 16/297 (5%) Query: 319 YSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQ-IDVAIKVLKQG-TE 376 SD + K + + + + + LG G FGSVR+ + + VA+K+LK Sbjct: 7 ISDELKEKLEDVLIPEQQFTLGRM-LGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIA 65 Query: 377 KADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA-------LMLVMEMAGGGPLHKFLVGK 429 +D EE +REA M + D+P++ +L+GV M+++ G LH FL+ Sbjct: 66 SSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLAS 125 Query: 430 R-----EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSK 484 R +P+ + + ++ GM+YL +NF+HRDLAARN +L ++DFGLS+ Sbjct: 126 RIGENPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSR 185 Query: 485 ALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMK 544 + + D YY A K P+KW A E + ++ SDVW++GVTMWE ++ GQ PY ++ Sbjct: 186 KIYSGD-YYRQGCASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIE 244 Query: 545 GPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLA 601 E+ ++ G R++ PPEC E+Y LM CW + RP F + + L+ Sbjct: 245 NAEIYNYLIGGNRLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGHLS 301 >6DBN-A nrPDB Length = 316 Score = 274 bits (701), Expect = 8e-74, Method: Composition-based stats. Identities = 100/294 (34%), Positives = 147/294 (50%), Gaps = 21/294 (7%) Query: 322 PEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQI--DVAIKVLKQGTEKAD 379 P D F KR I D LG G+FG V Y VA+K LK + Sbjct: 23 PATEVDPTHFEKRFLKRIRD--LGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNH 80 Query: 380 TEEMMREAQIMHQLDNPYIVRLIGVCQAEA---LMLVMEMAGGGPLHKFLVGKREEIPVS 436 ++ +E +I+ L + IV+ G+C + + L+ME G L ++L + +I + Sbjct: 81 IADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLK 140 Query: 437 NVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTAR 496 + Q+ GM YL + +VHRDLAARNVL+ + H KI DFGL+KA+ D YYT + Sbjct: 141 QQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVK 200 Query: 497 SAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQ--------------KPYKK 542 P+ WYAPEC+ KF SDVWS+GVT+ E L+Y + + Sbjct: 201 DDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQ 260 Query: 543 MKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRAC 596 M ++ +++GKR+ CPP CP E+Y LM CW ++ +R F + + A Sbjct: 261 MTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL 314 >2W1I-A nrPDB Length = 326 Score = 272 bits (696), Expect = 3e-73, Method: Composition-based stats. Identities = 98/302 (32%), Positives = 150/302 (49%), Gaps = 29/302 (9%) Query: 321 DPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYR--MRKKQIDVAIKVLKQGTEKA 378 DP + +++ L + +LG GNFGSV Y VA+K L+ TE+ Sbjct: 34 DPTQFEERHLKFLQ--------QLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEE- 84 Query: 379 DTEEMMREAQIMHQLDNPYIVRLIGVCQA---EALMLVMEMAGGGPLHKFLVGKREEIPV 435 + RE +I+ L + IV+ GVC + L L+ME G L +L +E I Sbjct: 85 HLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDH 144 Query: 436 SNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTA 495 + + Q+ GM+YL K ++HRDLA RN+L+ N + KI DFGL+K L D YY Sbjct: 145 IKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKV 204 Query: 496 RSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQ----KP--YKKMKGPE-- 547 + G+ P+ WYAPE + KFS SDVWS+GV ++E +Y + P + +M G + Sbjct: 205 KEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQ 264 Query: 548 -------VMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL 600 ++ ++ R+ P CP E+Y +M++CW RP F + R+ + Sbjct: 265 GQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDQM 324 Query: 601 AS 602 A Sbjct: 325 AG 326 >3IO7-A nrPDB Length = 313 Score = 271 bits (693), Expect = 6e-73, Method: Composition-based stats. Identities = 96/297 (32%), Positives = 146/297 (49%), Gaps = 22/297 (7%) Query: 326 KDKKLFLKRDNLLIADIELGCGNFGSVRQGVYR--MRKKQIDVAIKVLKQGTEKADTEEM 383 + +L +LG GNFGSV Y VA+K L+ TE+ + Sbjct: 19 SHNMTQFEERHLKFL-QQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEE-HLRDF 76 Query: 384 MREAQIMHQLDNPYIVRLIGVCQA---EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAE 440 RE +I+ L + IV+ GVC + L L+ME G L +L +E I + + Sbjct: 77 EREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQ 136 Query: 441 LLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK 500 Q+ GM+YL K ++HRDLA RN+L+ N + KI DFGL+K L D YY + G+ Sbjct: 137 YTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGE 196 Query: 501 WPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQ----KP--YKKMKGPE------- 547 P+ WYAPE + KFS SDVWS+GV ++E +Y + P + +M G + Sbjct: 197 SPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIV 256 Query: 548 --VMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLAS 602 ++ ++ R+ P CP E+Y +M++CW RP F + R+ ++A Sbjct: 257 FHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 313 >6FEX-A nrPDB Length = 321 Score = 270 bits (691), Expect = 1e-72, Method: Composition-based stats. Identities = 93/301 (30%), Positives = 146/301 (48%), Gaps = 37/301 (12%) Query: 328 KKLFLKRDNLLIADIELGCGNFGSVRQGVYRM--------------RKKQIDVAIKVLKQ 373 ++ R L + +LG G FG V + + VA+K+L+ Sbjct: 9 PRVDFPRSRLRFKE-KLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRP 67 Query: 374 GTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGK--- 429 K + ++E +IM +L +P I+RL+GVC Q + L ++ + G L++FL Sbjct: 68 DATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLE 127 Query: 430 ---------REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDF 480 I + + Q++ GM+YL NFVHRDLA RN L+ KI+DF Sbjct: 128 DKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADF 187 Query: 481 GLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQ-KP 539 G+S+ L A D YY + P++W A ECI KF++ SDVW++GVT+WE L + +P Sbjct: 188 GMSRNLYAGD-YYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQP 246 Query: 540 YKKMKGPEVMAFIEQGKR-------MECPPECPPELYALMSDCWIYKWEDRPDFLTVEQR 592 + ++ +V+ + R + PP CP LY LM CW + E RP F + + Sbjct: 247 FGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRF 306 Query: 593 M 593 + Sbjct: 307 L 307 >3PLS-A nrPDB Length = 298 Score = 270 bits (691), Expect = 1e-72, Method: Composition-based stats. Identities = 90/283 (31%), Positives = 149/283 (52%), Gaps = 5/283 (1%) Query: 325 LKDKKLFLKRDNLLI-ADIELGCGNFGSVRQGVYRMRKKQ-IDVAIKVLKQGTEKADTEE 382 + K + + + ++ +D +G G+FG V G Y + + I AIK L + TE E Sbjct: 9 AEVKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEA 68 Query: 383 MMREAQIMHQLDNPYIVRLIGV-CQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAE 440 +RE +M L++P ++ LIG+ E L +++ G L +F+ + V ++ Sbjct: 69 FLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLIS 128 Query: 441 LLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTAR-SAG 499 QV+ GM+YL E+ FVHRDLAARN +L K++DFGL++ + + Y + Sbjct: 129 FGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHA 188 Query: 500 KWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRME 559 + P+KW A E + +F+++SDVWS+GV +WE L+ G PY+ + ++ F+ QG+R+ Sbjct: 189 RLPVKWTALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLP 248 Query: 560 CPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLAS 602 P CP LY +M CW RP F + + +L Sbjct: 249 QPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALLG 291 >3AOX-A nrPDB Length = 344 Score = 268 bits (686), Expect = 4e-72, Method: Composition-based stats. Identities = 98/293 (33%), Positives = 148/293 (50%), Gaps = 22/293 (7%) Query: 317 SPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQ---IDVAIKVLKQ 373 S SD +E+ K + L R LG G FG V +G + VA+K L + Sbjct: 36 SSISDLKEVPRKNITLIRG--------LGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPE 87 Query: 374 GTEKADTEEMMREAQIMHQLDNPYIVRLIGV-CQAEALMLVMEMAGGGPLHKFLVGKREE 432 + D + + EA I+ + ++ IVR IGV Q+ +++E+ GG L FL R Sbjct: 88 VCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPR 147 Query: 433 IPVS------NVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRH---YAKISDFGLS 483 ++ + ++ G +YLEE +F+HRD+AARN LL AKI DFG++ Sbjct: 148 PSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMA 207 Query: 484 KALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKM 543 + + SYY P+KW PE F+S++D WS+GV +WE S G PY Sbjct: 208 RDIYRA-SYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSK 266 Query: 544 KGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRAC 596 EV+ F+ G RM+ P CP +Y +M+ CW ++ EDRP+F + +R+ C Sbjct: 267 SNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYC 319 >6BSD-A nrPDB Length = 876 Score = 266 bits (681), Expect = 2e-71, Method: Composition-based stats. Identities = 93/307 (30%), Positives = 147/307 (47%), Gaps = 43/307 (14%) Query: 328 KKLFLKRDNLLIADIELGCGNFGSVRQGVYRM--------------RKKQIDVAIKVLKQ 373 ++ R L + +LG G FG V + + VA+K+L+ Sbjct: 564 PRVDFPRSRLRFKE-KLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRP 622 Query: 374 GTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKR-- 430 K + ++E +IM +L +P I+RL+GVC Q + L ++ + G L++FL + Sbjct: 623 DATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLE 682 Query: 431 ----------------EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHY 474 I + + Q++ GM+YL NFVHRDLA RN L+ Sbjct: 683 DKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFT 742 Query: 475 AKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALS 534 KI+DFG+S+ L A D YY + P++W A ECI KF++ SDVW++GVT+WE L Sbjct: 743 IKIADFGMSRNLYAGD-YYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLM 801 Query: 535 YGQ-KPYKKMKGPEVMAFIEQGKR-------MECPPECPPELYALMSDCWIYKWEDRPDF 586 + +P+ ++ +V+ + R + PP CP LY LM CW + E RP F Sbjct: 802 LCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPF 861 Query: 587 LTVEQRM 593 + + + Sbjct: 862 SQLHRFL 868 >5WNO-A nrPDB Length = 330 Score = 266 bits (679), Expect = 3e-71, Method: Composition-based stats. Identities = 94/260 (36%), Positives = 145/260 (55%), Gaps = 7/260 (2%) Query: 341 DIELGCGNFGSVRQGVY---RMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPY 397 D +LG G FG+V G+Y R + +I VAIKV + + D EM+ EA M +L + Sbjct: 27 DKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTD--EMLEEATNMFRLRHDN 84 Query: 398 IVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 ++++IG C + L +V G L FL +E + +Q++ GM+YLE++ Sbjct: 85 LLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQR 144 Query: 457 FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKF 516 VHRDLA RNVL+ ++ +I+DFGLSK L D T +S GK +KW A E + + Sbjct: 145 VVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKS-GKVAIKWLAIEIFSKHCY 203 Query: 517 SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCW 576 + SDVW++GVT WE +++GQ PY+ M + F++ G R+ PP C +LY + CW Sbjct: 204 THASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCW 263 Query: 577 IYKWEDRPDFLTVEQRMRAC 596 + + RP F + +R + Sbjct: 264 MADPKSRPGFEILYERFKEF 283 >6FER-A nrPDB Length = 309 Score = 265 bits (678), Expect = 3e-71, Method: Composition-based stats. Identities = 90/295 (30%), Positives = 146/295 (49%), Gaps = 34/295 (11%) Query: 331 FLKRDNLLIADIELGCGNFGSVRQG--------------VYRMRKKQIDVAIKVLKQGTE 376 R L + +LG G FG V + + + VA+K+L+ Sbjct: 5 EFPRKLLTFKE-KLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADAN 63 Query: 377 KADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPV 435 K + ++E +IM +L +P I+ L+ VC + L ++ E G L++FL Sbjct: 64 KNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSS 123 Query: 436 S---------NVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKAL 486 S N+ + Q++ GMKYL NFVHRDLA RN L+ + KI+DFG+S+ L Sbjct: 124 SSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNL 183 Query: 487 GADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQ-KPYKKMKG 545 + D YY + P++W + E I KF++ SDVW++GVT+WE ++ Q +PY ++ Sbjct: 184 YSGD-YYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSD 242 Query: 546 PEVMA-----FIEQGKR--MECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRM 593 +V+ F +QG++ + P CP +Y LM CW ++RP F + + Sbjct: 243 EQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLL 297 >4HVI-A nrPDB Length = 314 Score = 263 bits (672), Expect = 2e-70, Method: Composition-based stats. Identities = 104/291 (35%), Positives = 151/291 (51%), Gaps = 22/291 (7%) Query: 326 KDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQID--VAIKVLKQGTEKADTEEM 383 +D +F +R I+ +LG GNFGSV Y VA+K L Q + + Sbjct: 2 QDPTIFEERHLKYIS--QLGKGNFGSVELCRYDPLGDNTGALVAVKQL-QHSGPDQQRDF 58 Query: 384 MREAQIMHQLDNPYIVRLIGVCQAEA---LMLVMEMAGGGPLHKFLVGKREEIPVSNVAE 440 RE QI+ L + +IV+ GV L LVME G L FL R + S + Sbjct: 59 QREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLL 118 Query: 441 LLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK 500 Q+ GM+YL + VHRDLAARN+L+ + + KI+DFGL+K L D YY R G+ Sbjct: 119 YSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQ 178 Query: 501 WPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQK---P---YKKMKGPE------- 547 P+ WYAPE ++ FS +SDVWS+GV ++E +Y K P + +M G E Sbjct: 179 SPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALS 238 Query: 548 -VMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACY 597 ++ +E+G+R+ PP CP E++ LM CW +DRP F + ++ + Sbjct: 239 RLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLW 289 >3ZZW-A nrPDB Length = 289 Score = 263 bits (671), Expect = 2e-70, Method: Composition-based stats. Identities = 98/272 (36%), Positives = 138/272 (50%), Gaps = 20/272 (7%) Query: 343 ELGCGNFGSVRQGVY---RMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIV 399 ELG FG V +G ++ VAIK LK E EE EA + +L +P +V Sbjct: 16 ELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVV 75 Query: 400 RLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPV---------------SNVAELLH 443 L+GV + L ++ G LH+FLV + V + L+ Sbjct: 76 CLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVA 135 Query: 444 QVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPL 503 Q++ GM+YL + VH+DLA RNVL+ ++ KISD GL + + A D YY P+ Sbjct: 136 QIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAAD-YYKLLGNSLLPI 194 Query: 504 KWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE 563 +W APE I + KFS SD+WSYGV +WE SYG +PY +V+ I + + CP + Sbjct: 195 RWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDD 254 Query: 564 CPPELYALMSDCWIYKWEDRPDFLTVEQRMRA 595 CP +YALM +CW RP F + R+RA Sbjct: 255 CPAWVYALMIECWNEFPSRRPRFKDIHSRLRA 286 >3PPZ-A nrPDB Length = 309 Score = 262 bits (670), Expect = 3e-70, Method: Composition-based stats. Identities = 83/266 (31%), Positives = 141/266 (53%), Gaps = 15/266 (5%) Query: 341 DIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADT-EEMMREAQIMHQLDNPYIV 399 ++G G+FG+V + + DVA+K+L + A+ E +RE IM +L +P IV Sbjct: 42 KEKIGAGSFGTVHRAEW----HGSDVAVKILMEQDFHAERVNEFLREVAIMKRLRHPNIV 97 Query: 400 RLIG-VCQAEALMLVMEMAGGGPLHKFLVGK--REEIPVSNVAELLHQVSMGMKYLEEKN 456 +G V Q L +V E G L++ L RE++ + + V+ GM YL +N Sbjct: 98 LFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRN 157 Query: 457 --FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR 514 VHRDL + N+L+ ++ K+ DFGLS+ ++ +++SA P +W APE + Sbjct: 158 PPIVHRDLKSPNLLVDKKYTVKVCDFGLSRL--KASTFLSSKSAAGTP-EWMAPEVLRDE 214 Query: 515 KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIE-QGKRMECPPECPPELYALMS 573 + +SDV+S+GV +WE + Q+P+ + +V+A + + KR+E P P++ A++ Sbjct: 215 PSNEKSDVYSFGVILWELATL-QQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAAIIE 273 Query: 574 DCWIYKWEDRPDFLTVEQRMRACYYS 599 CW + RP F T+ +R S Sbjct: 274 GCWTNEPWKRPSFATIMDLLRPLIKS 299 >4UY9-A nrPDB Length = 323 Score = 259 bits (663), Expect = 2e-69, Method: Composition-based stats. Identities = 91/286 (31%), Positives = 139/286 (48%), Gaps = 29/286 (10%) Query: 330 LFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKA---DTEEMMRE 386 L + L + +I +G G FG V + + +VA+K + ++ E + +E Sbjct: 4 LEIDFAELTLEEI-IGIGGFGKVYRAFWIGD----EVAVKAARHDPDEDISQTIENVRQE 58 Query: 387 AQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQV 445 A++ L +P I+ L GVC E L LVME A GGPL++ L GKR IP + Q+ Sbjct: 59 AKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKR--IPPDILVNWAVQI 116 Query: 446 SMGMKYLEEK---NFVHRDLAARNVLLV--------NRHYAKISDFGLSKALGADDSYYT 494 + GM YL ++ +HRDL + N+L++ + KI+DFGL++ + + T Sbjct: 117 ARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR-----EWHRT 171 Query: 495 ARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 554 + + W APE I FS SDVWSYGV +WE L+ G+ P++ + G V + Sbjct: 172 TKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVAM 230 Query: 555 GK-RMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYS 599 K + P CP LM DCW RP F + ++ S Sbjct: 231 NKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEES 276 >3DTC-A nrPDB Length = 271 Score = 259 bits (662), Expect = 3e-69, Method: Composition-based stats. Identities = 90/283 (31%), Positives = 138/283 (48%), Gaps = 29/283 (10%) Query: 330 LFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKA---DTEEMMRE 386 L + L + +I +G G FG V + + +VA+K + ++ E + +E Sbjct: 2 LEIDFAELTLEEI-IGIGGFGKVYRAFWIGD----EVAVKAARHDPDEDISQTIENVRQE 56 Query: 387 AQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQV 445 A++ L +P I+ L GVC E L LVME A GGPL++ L GKR IP + Q+ Sbjct: 57 AKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKR--IPPDILVNWAVQI 114 Query: 446 SMGMKYLEEK---NFVHRDLAARNVLLV--------NRHYAKISDFGLSKALGADDSYYT 494 + GM YL ++ +HRDL + N+L++ + KI+DFGL++ + + T Sbjct: 115 ARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR-----EWHRT 169 Query: 495 ARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 554 + + W APE I FS SDVWSYGV +WE L+ G+ P++ + G V + Sbjct: 170 TKMSAAGAYAWMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVAM 228 Query: 555 GK-RMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRAC 596 K + P CP LM DCW RP F + ++ Sbjct: 229 NKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTI 271 >4UYA-A nrPDB Length = 340 Score = 257 bits (656), Expect = 1e-68, Method: Composition-based stats. Identities = 91/299 (30%), Positives = 147/299 (49%), Gaps = 29/299 (9%) Query: 325 LKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADT---E 381 + + + + L + ++ +G G FG V + + + +VA+K +Q E+ E Sbjct: 16 FQGSPVHVAFERLELKEL-IGAGGFGQVYRATW----QGQEVAVKAARQDPEQDAAAAAE 70 Query: 382 EMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAE 440 + REA++ L +P I+ L GVC Q L LV+E A GG L++ L G+R IP + Sbjct: 71 SVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAGRR--IPPHVLVN 128 Query: 441 LLHQVSMGMKYLEEK---NFVHRDLAARNVLLVN--------RHYAKISDFGLSKALGAD 489 Q++ GM YL E+ +HRDL + N+LL+ KI+DFGL++ Sbjct: 129 WAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAR----- 183 Query: 490 DSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVM 549 + + T + A W APE I FS SD+WSYGV +WE L+ G+ PY+ + G V Sbjct: 184 EWHRTTKMATAGAYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLT-GEVPYRGIDGLAVA 242 Query: 550 AFIEQGK-RMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGP 607 + K + P CP LM +CW RP F + +++ A ++ +++ Sbjct: 243 YGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQE 301 >4GS6-A nrPDB Length = 315 Score = 256 bits (653), Expect = 3e-68, Method: Composition-based stats. Identities = 75/275 (27%), Positives = 124/275 (45%), Gaps = 25/275 (9%) Query: 332 LKRDNLLIADIE--LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQI 389 L + ++E +G G FG V + +R + VAIK + +++ + + E + Sbjct: 3 LHMIDYKEIEVEEVVGRGAFGVVCKAKWRAKD----VAIKQI---ESESERKAFIVELRQ 55 Query: 390 MHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKRE--EIPVSNVAELLHQVSM 447 + ++++P IV+L G C + LVME A GG L+ L G ++ Q S Sbjct: 56 LSRVNHPNIVKLYGACL-NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQ 114 Query: 448 GMKYLEEKN---FVHRDLAARNVLLVNRHYA-KISDFGLSKALGADDSYYTARSAGKWPL 503 G+ YL +HRDL N+LLV KI DFG + + T + K Sbjct: 115 GVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDI------QTHMTNNKGSA 168 Query: 504 KWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP--EVMAFIEQGKRMECP 561 W APE +S + DV+S+G+ +WE ++ +KP+ ++ GP +M + G R Sbjct: 169 AWMAPEVFEGSNYSEKCDVFSWGIILWEVITR-RKPFDEIGGPAFRIMWAVHNGTRPPLI 227 Query: 562 PECPPELYALMSDCWIYKWEDRPDFLTVEQRMRAC 596 P + +LM+ CW RP + + M Sbjct: 228 KNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHL 262 >3LMG-A nrPDB Length = 344 Score = 253 bits (647), Expect = 1e-67, Method: Composition-based stats. Identities = 102/297 (34%), Positives = 155/297 (52%), Gaps = 10/297 (3%) Query: 321 DPEELKDKKL--FLKRDNLLIADIELGCGNFGSVRQGVYRMRKK--QIDVAIKVLKQGTE 376 DP E +K L K L + LG G FG+V +GV+ + +I V IKV++ + Sbjct: 15 DPSEKANKVLARIFKETELRKLKV-LGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSG 73 Query: 377 KADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVS 436 + + + + LD+ +IVRL+G+C +L LV + G L + R + Sbjct: 74 RQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQ 133 Query: 437 NVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTAR 496 + Q++ GM YLEE VHR+LAARNVLL + +++DFG++ L DD Sbjct: 134 LLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDK-QLLY 192 Query: 497 SAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK 556 S K P+KW A E I+F K++ +SDVWSYGVT+WE +++G +PY ++ EV +E+G+ Sbjct: 193 SEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGE 252 Query: 557 RMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRM----RACYYSLASKVEGPPG 609 R+ P C ++Y +M CW+ RP F + R L K E PG Sbjct: 253 RLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPG 309 >4MVF-A nrPDB Length = 506 Score = 253 bits (645), Expect = 2e-67, Method: Composition-based stats. Identities = 72/278 (25%), Positives = 126/278 (45%), Gaps = 20/278 (7%) Query: 333 KRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQ 392 K ++ I D +LG G +G V +G+ ++ + AIK K+ K + +E +IM + Sbjct: 54 KLEDKYIIDEKLGQGTYGCVYKGIDKVTNQ--LYAIKEEKKDRLK-NINRFFQEIEIMKK 110 Query: 393 LDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKY 451 LD+P IV+L + + + L+ME+ G L ++ N A ++ Q+ + Y Sbjct: 111 LDHPNIVKLYETYENDNYIYLIMELCSGRELFDSIIENGS-FTEKNAATIMKQIFSAIFY 169 Query: 452 LEEKNFVHRDLAARNVLL---VNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 L N VHRDL N L KI DFGLSK LG + T + AP Sbjct: 170 LHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTK----AGTPYYVAP 225 Query: 509 ECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE---CP 565 + ++ + + + D+WS GV M+ L G P+ EV+ +++G+ + Sbjct: 226 QVLDGK-YDKKCDIWSSGVIMYTLLC-GYPPFYGDTDNEVLKKVKKGEFCFYENDWGSIS 283 Query: 566 PELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASK 603 + L++ Y +R T+E+ + + + +K Sbjct: 284 SDAKNLITKLLTYNPNER---CTIEEALNHPWITQMTK 318 >5X5O-A nrPDB Length = 310 Score = 252 bits (644), Expect = 3e-67, Method: Composition-based stats. Identities = 77/278 (27%), Positives = 130/278 (46%), Gaps = 24/278 (8%) Query: 330 LFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQI 389 + +K D+L + G G+FGSV + + + K+ VA+K L + + +EA+I Sbjct: 10 VQIKFDDLQFFENC-GGGSFGSVYRAKWISQDKE--VAVKKLLK---------IEKEAEI 57 Query: 390 MHQLDNPYIVRLIGVCQAEALM-LVMEMAGGGPLHKFLVGKR-EEIPVSNVAELLHQVSM 447 + L + I++ GV +V E A G L+ ++ R EE+ + ++ V+ Sbjct: 58 LSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAK 117 Query: 448 GMKYLEEK---NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLK 504 GM YL + +HRDL +RNV++ KI DFG S+ +T + Sbjct: 118 GMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF-----HNHTTHMSLVGTFP 172 Query: 505 WYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAF-IEQGKRMECPPE 563 W APE I S D +SYGV +WE L+ + P+K ++G +V +E+ +R+ P Sbjct: 173 WMAPEVIQSLPVSETCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSS 231 Query: 564 CPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLA 601 CP L+ CW + RP F + + + + Sbjct: 232 CPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTS 269 >2QNJ-A nrPDB Length = 328 Score = 251 bits (640), Expect = 8e-67, Method: Composition-based stats. Identities = 69/260 (26%), Positives = 112/260 (43%), Gaps = 13/260 (5%) Query: 336 NLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTEEMMREAQIMHQLD 394 N + +G GNF V+ + + ++ VAIK++ K +++ RE +IM L+ Sbjct: 13 NYRLLKT-IGKGNFAKVKLARHILTGRE--VAIKIIDKTQLNPTSLQKLFREVRIMKILN 69 Query: 395 NPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 +P IV+L V + E L L+ME A GG + +LV + Q+ ++Y Sbjct: 70 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAH-GRMKEKEARSKFRQIVSAVQYCH 128 Query: 454 EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF 513 +K VHRDL A N+LL KI+DFG S T + + APE Sbjct: 129 QKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGS----PPYAAPELFQG 184 Query: 514 RKFS-SRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALM 572 +K+ DVWS GV ++ +S G P+ E+ + +GK P + L+ Sbjct: 185 KKYDGPEVDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRGKY-RIPFYMSTDCENLL 242 Query: 573 SDCWIYKWEDRPDFLTVEQR 592 + R + + Sbjct: 243 KRFLVLNPIKRGTLEQIMKD 262 >5ES1-A nrPDB Length = 328 Score = 250 bits (639), Expect = 1e-66, Method: Composition-based stats. Identities = 73/281 (25%), Positives = 120/281 (42%), Gaps = 18/281 (6%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 +G GNF V+ + + ++ VAIK++ K + +++ RE +IM L++P IV+L Sbjct: 23 IGKGNFAKVKLARHILTGRE--VAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLF 80 Query: 403 GVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 V + E L LVME A G + +LV + Q+ + Y +KN VHRD Sbjct: 81 EVIETEKTLYLVMEYASAGEVFDYLVSH-GRMKEKEARAKFRQIVSAVHYCHQKNIVHRD 139 Query: 462 LAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFS-SRS 520 L A N+LL KI+DFG S T + + APE +K+ Sbjct: 140 LKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGS----PPYAAPELFQGKKYDGPEV 195 Query: 521 DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKW 580 D+WS GV ++ +S G P+ E+ + +GK P + +++ + Sbjct: 196 DIWSLGVILYTLVS-GSLPFDGHNLKELRERVLRGKY-RVPFYMSTDCESILRRFLVLNP 253 Query: 581 EDRPDFLTVE--QRMRACYYSLASK----VEGPPGSTQKAE 615 R + + + Y K E G T++ E Sbjct: 254 AKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIE 294 >5KZ7-A nrPDB Length = 346 Score = 250 bits (638), Expect = 2e-66, Method: Composition-based stats. Identities = 71/260 (27%), Positives = 114/260 (43%), Gaps = 13/260 (5%) Query: 336 NLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTEEMMREAQIMHQLD 394 N + +G GNF V+ + + K+ VA+K++ K + +++ RE +IM L+ Sbjct: 34 NYRLLKT-IGKGNFAKVKLARHILTGKE--VAVKIIDKTQLNSSSLQKLFREVRIMKVLN 90 Query: 395 NPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 +P IV+L V + E L LVME A GG + +LV + Q+ ++Y Sbjct: 91 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAH-GRMKEKEARAKFRQIVSAVQYCH 149 Query: 454 EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF 513 +K VHRDL A N+LL KI+DFG S + T + + APE Sbjct: 150 QKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGS----PPYAAPELFQG 205 Query: 514 RKFS-SRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALM 572 +K+ DVWS GV ++ +S G P+ E+ + +GK P + L+ Sbjct: 206 KKYDGPEVDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRGKY-RIPFYMSTDCENLL 263 Query: 573 SDCWIYKWEDRPDFLTVEQR 592 I R + + Sbjct: 264 KKFLILNPSKRGTLEQIMKD 283 >5EZV-A nrPDB Length = 560 Score = 249 bits (637), Expect = 2e-66, Method: Composition-based stats. Identities = 72/309 (23%), Positives = 123/309 (39%), Gaps = 20/309 (6%) Query: 320 SDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKAD 379 DP E + +K + ++ D LG G FG V+ G +++ + VA+K+L + ++ Sbjct: 13 QDPAEKQKHDGRVKIGHYVLGDT-LGVGTFGKVKIGEHQLTGHK--VAVKILNRQKIRSL 69 Query: 380 --TEEMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVS 436 ++ RE Q + +P+I++L V +VME GG L ++ K + Sbjct: 70 DVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC-KHGRVEEM 128 Query: 437 NVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTAR 496 L Q+ + Y VHRDL NVLL AKI+DFGLS + + T+ Sbjct: 129 EARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSC 188 Query: 497 SAGKWPLKWYAPECINFRKF-SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG 555 + + APE I+ R + D+WS GV ++ L G P+ P + I +G Sbjct: 189 GS----PNYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RG 242 Query: 556 KRMECPPECPPELYALMSDCWIYKWEDRPDFLTVE------QRMRACYYSLASKVEGPPG 609 P + L+ R + Q + + + + Sbjct: 243 GVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVI 302 Query: 610 STQKAEAAC 618 + + C Sbjct: 303 DDEAVKEVC 311 >3HZT-A nrPDB Length = 467 Score = 248 bits (634), Expect = 4e-66, Method: Composition-based stats. Identities = 67/249 (26%), Positives = 112/249 (44%), Gaps = 14/249 (5%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 +LG G +G V ++ + + I T +++ ++ E ++ QLD+P I++L Sbjct: 10 KKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPNIMKL 69 Query: 402 IGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 + + LVME+ GG L ++ R++ + A ++ QV G YL + N VHR Sbjct: 70 YEFFEDKRNYYLVMEVYRGGELFDEIIL-RQKFSEVDAAVIMKQVLSGTTYLHKHNIVHR 128 Query: 461 DLAARNVLLVNRHY---AKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFS 517 DL N+LL ++ KI DFGLS + APE + +K+ Sbjct: 129 DLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERL----GTAYYIAPEVLR-KKYD 183 Query: 518 SRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE---CPPELYALMSD 574 + DVWS GV ++ L G P+ E++ +E+GK PP+ E L+ Sbjct: 184 EKCDVWSCGVILYILLC-GYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLVKL 242 Query: 575 CWIYKWEDR 583 Y+ R Sbjct: 243 MLTYEPSKR 251 >3NCG-A nrPDB Length = 486 Score = 248 bits (634), Expect = 4e-66, Method: Composition-based stats. Identities = 74/280 (26%), Positives = 128/280 (45%), Gaps = 20/280 (7%) Query: 320 SDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEK-A 378 S E L + F +R N++ LG G+FG V + R+ Q + A+KV+ + + K Sbjct: 9 SGRENLYFQGTFAERYNIVC---MLGKGSFGEVLKCKDRIT--QQEYAVKVINKASAKNK 63 Query: 379 DTEEMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSN 437 DT ++RE +++ +LD+P I++L + + + +V E+ GG L ++ KR+ + Sbjct: 64 DTSTILREVELLKKLDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEII-KRKRFSEHD 122 Query: 438 VAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKALGADDSYYT 494 A ++ QV G+ Y+ + N VHRDL N+LL + KI DFGLS + T Sbjct: 123 AARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQN----T 178 Query: 495 ARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 554 + APE + + + DVWS GV ++ LS G P+ +++ +E Sbjct: 179 KMKDRIGTAYYIAPEVLRGT-YDEKCDVWSAGVILYILLS-GTPPFYGKNEYDILKRVET 236 Query: 555 GKR---MECPPECPPELYALMSDCWIYKWEDRPDFLTVEQ 591 GK + + L+ + R + Sbjct: 237 GKYAFDLPQWRTISDDAKDLIRKMLTFHPSLRITATQCLE 276 >5JN2-A nrPDB Length = 525 Score = 248 bits (634), Expect = 4e-66, Method: Composition-based stats. Identities = 74/305 (24%), Positives = 124/305 (40%), Gaps = 19/305 (6%) Query: 295 EPARITSPDKPRPMPMDTSVYESP----YSDPEELKDKKLFLKRDNLLIADIELGCGNFG 350 E + +PR P ++ P + D LG G+FG Sbjct: 23 ESTLGGAAGEPRSRGHAAGTSGGPGDHLHATPGMFVQHSTAIFSDRYK-GQRVLGKGSFG 81 Query: 351 SVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA- 409 V ++ ++ V + +Q +K D E ++RE Q++ QLD+P I++L + + Sbjct: 82 EVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGY 141 Query: 410 LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLL 469 LV E+ GG L ++ R+ + A ++ QV G+ Y+ + VHRDL N+LL Sbjct: 142 FYLVGEVYTGGELFDEIIS-RKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLL 200 Query: 470 VN---RHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYG 526 + +I DFGLS A + APE ++ + + DVWS G Sbjct: 201 ESKSKDANIRIIDFGLSTHFEASKKMKDK----IGTAYYIAPEVLHGT-YDEKCDVWSTG 255 Query: 527 VTMWEALSYGQKPYKKMKGPEVMAFIEQGKR-MECPP--ECPPELYALMSDCWIYKWEDR 583 V ++ LS G P+ +++ +E+GK E P + L+ Y R Sbjct: 256 VILYILLS-GCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMR 314 Query: 584 PDFLT 588 Sbjct: 315 ISARD 319 >5IG1-A nrPDB Length = 344 Score = 247 bits (632), Expect = 7e-66, Method: Composition-based stats. Identities = 61/276 (22%), Positives = 116/276 (42%), Gaps = 16/276 (5%) Query: 325 LKDKKLFLKRDNLLIADIE--LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEE 382 ++ + F ++ + D +G G F +V + V + + V + LK ++ + Sbjct: 4 METETSFFDLYDVDLKDKRSVIGKGAFSTVHRCVNKRTGEVCAVKVIALK-SLRSSEINK 62 Query: 383 MMREAQIMHQLDNPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAEL 441 + RE I L + +IV + + E LV E GG L +V ++ + + Sbjct: 63 IKREIGICSSLQHEHIVSMRRAFRDESHFYLVFEYVSGGELFDEIVTRKF-YNEKDASAC 121 Query: 442 LHQVSMGMKYLEEKNFVHRDLAARNVLLVNRH---YAKISDFGLSKALGADDSYYTARSA 498 +HQ+ +++ KN +HRDL N+LL ++ KI+DFGL+ + +Y+ Sbjct: 122 MHQILSALQHCHSKNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYF----G 177 Query: 499 GKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM 558 + +PE I + + DVW+ GV ++ L G P+ + ++ A I+ + Sbjct: 178 FAGTPGYLSPEVIRRVPYDTAVDVWACGVILYILL-VGYPPFWEEDHQKLYAQIKNCQYD 236 Query: 559 ECPPE---CPPELYALMSDCWIYKWEDRPDFLTVEQ 591 PE L+ + RP + Q Sbjct: 237 FPSPEWDSVTTAAKELIKAMLEPNPKRRPTVQELLQ 272 >3Q5I-A nrPDB Length = 504 Score = 247 bits (630), Expect = 1e-65, Method: Composition-based stats. Identities = 71/278 (25%), Positives = 118/278 (42%), Gaps = 28/278 (10%) Query: 325 LKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG---------- 374 + +K K +LG G +G V + + + AIKV+K+ Sbjct: 25 MYVRKKEGKIGESYFKVRKLGSGAYGEVLLC--KEKNGHSEKAIKVIKKSQFDKGRYSDD 82 Query: 375 --TEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKRE 431 + EE+ E ++ LD+P I++L V + + LV E GG L + ++ R Sbjct: 83 NKNIEKFHEEIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQII-NRH 141 Query: 432 EIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRH---YAKISDFGLSKALGA 488 + + A ++ Q+ G+ YL + N VHRD+ N+LL N++ KI DFGLS Sbjct: 142 KFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSK 201 Query: 489 DDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEV 548 D + APE + +K++ + DVWS GV M+ L G P+ ++ Sbjct: 202 DYKLRDRL----GTAYYIAPEVLK-KKYNEKCDVWSCGVIMYILLC-GYPPFGGQNDQDI 255 Query: 549 MAFIEQGKRMECP---PECPPELYALMSDCWIYKWEDR 583 + +E+GK E L+ Y + R Sbjct: 256 IKKVEKGKYYFDFNDWKNISDEAKELIKLMLTYDYNKR 293 >3DFA-A nrPDB Length = 286 Score = 247 bits (630), Expect = 1e-65, Method: Composition-based stats. Identities = 74/280 (26%), Positives = 128/280 (45%), Gaps = 20/280 (7%) Query: 320 SDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEK-A 378 S E L + F +R N++ LG G+FG V + R+ Q + A+KV+ + + K Sbjct: 9 SGRENLYFQGTFAERYNIVC---MLGKGSFGEVLKCKDRIT--QQEYAVKVINKASAKNK 63 Query: 379 DTEEMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSN 437 DT ++RE +++ +LD+P I++L + + + +V E+ GG L ++ KR+ + Sbjct: 64 DTSTILREVELLKKLDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEII-KRKRFSEHD 122 Query: 438 VAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKALGADDSYYT 494 A ++ QV G+ Y+ + N VHRDL N+LL + KI DFGLS + T Sbjct: 123 AARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQN----T 178 Query: 495 ARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 554 + APE + + + DVWS GV ++ LS G P+ +++ +E Sbjct: 179 KMKDRIGTAYYIAPEVLRGT-YDEKCDVWSAGVILYILLS-GTPPFYGKNEYDILKRVET 236 Query: 555 GKR---MECPPECPPELYALMSDCWIYKWEDRPDFLTVEQ 591 GK + + L+ + R + Sbjct: 237 GKYAFDLPQWRTISDDAKDLIRKMLTFHPSLRITATQCLE 276 >3DXN-A nrPDB Length = 287 Score = 246 bits (629), Expect = 2e-65, Method: Composition-based stats. Identities = 67/249 (26%), Positives = 112/249 (44%), Gaps = 14/249 (5%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 +LG G +G V ++ + + I T +++ ++ E ++ QLD+P I++L Sbjct: 27 KKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPNIMKL 86 Query: 402 IGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 + + LVME+ GG L ++ R++ + A ++ QV G YL + N VHR Sbjct: 87 YEFFEDKRNYYLVMEVYRGGELFDEIIL-RQKFSEVDAAVIMKQVLSGTTYLHKHNIVHR 145 Query: 461 DLAARNVLLVNRHY---AKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFS 517 DL N+LL ++ KI DFGLS + APE + +K+ Sbjct: 146 DLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERL----GTAYYIAPEVLR-KKYD 200 Query: 518 SRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE---CPPELYALMSD 574 + DVWS GV ++ L G P+ E++ +E+GK PP+ E L+ Sbjct: 201 EKCDVWSCGVILYILLC-GYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLVKL 259 Query: 575 CWIYKWEDR 583 Y+ R Sbjct: 260 MLTYEPSKR 268 >3MA6-A nrPDB Length = 298 Score = 246 bits (628), Expect = 2e-65, Method: Composition-based stats. Identities = 70/279 (25%), Positives = 117/279 (41%), Gaps = 15/279 (5%) Query: 317 SPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE 376 + P + D LG G+FG V ++ ++ V + +Q + Sbjct: 14 LYFQGPGMFVQHSTAIFSDRYK-GQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQ 72 Query: 377 KADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPV 435 K D E ++RE Q++ QLD+P I++L + + LV E+ GG L ++ R+ Sbjct: 73 KTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIIS-RKRFSE 131 Query: 436 SNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKALGADDSY 492 + A ++ QV G+ Y+ + VHRDL N+LL + +I DFGLS A Sbjct: 132 VDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKM 191 Query: 493 YTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI 552 + APE ++ + + DVWS GV ++ LS G P+ +++ + Sbjct: 192 KDK----IGTAYYIAPEVLHGT-YDEKCDVWSTGVILYILLS-GCPPFNGANEYDILKKV 245 Query: 553 EQGKR-MECPP--ECPPELYALMSDCWIYKWEDRPDFLT 588 E+GK E P + L+ Y R Sbjct: 246 EKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISARD 284 >4CFF-A nrPDB Length = 571 Score = 246 bits (627), Expect = 3e-65, Method: Composition-based stats. Identities = 72/314 (22%), Positives = 124/314 (39%), Gaps = 21/314 (6%) Query: 316 ESPYSDPE-ELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG 374 E + P E + +K + ++ D LG G FG V+ G +++ + VA+K+L + Sbjct: 13 EVLFQGPMAEKQKHDGRVKIGHYVLGDT-LGVGTFGKVKIGEHQLTGHK--VAVKILNRQ 69 Query: 375 TEKAD--TEEMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKRE 431 ++ ++ RE Q + +P+I++L V +VME GG L ++ K Sbjct: 70 KIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC-KHG 128 Query: 432 EIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDS 491 + L Q+ + Y VHRDL NVLL AKI+DFGLS + + Sbjct: 129 RVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF 188 Query: 492 YYTARSAGKWPLKWYAPECINFRKF-SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMA 550 T+ + + APE I+ R + D+WS GV ++ L G P+ P + Sbjct: 189 LRTSCGS----PNYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFK 243 Query: 551 FIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVE------QRMRACYYSLASKV 604 I +G P + L+ R + Q + + + Sbjct: 244 KI-RGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSY 302 Query: 605 EGPPGSTQKAEAAC 618 + + + C Sbjct: 303 DANVIDDEAVKEVC 316 >3UTO-A nrPDB Length = 573 Score = 245 bits (625), Expect = 5e-65, Method: Composition-based stats. Identities = 76/371 (20%), Positives = 136/371 (36%), Gaps = 29/371 (7%) Query: 239 LKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGY-TPEPA 297 + K+ A N G + P P P + +R+ GY E Sbjct: 64 YTYTTIEGLRAGKQYEFRIIAENKHGQSKPCEPTAPVLIPGDERK----RRRGYDVDEQG 119 Query: 298 RITSPDKPRPMPMDTSVYE---SPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQ 354 +I D V++ Y P E+K + D+ I + ELG G FG V + Sbjct: 120 KIVRGKGTVSSNYDNYVFDIWKQYYPQPVEIKHDHVL---DHYDIHE-ELGTGAFGVVHR 175 Query: 355 GVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLV 413 R A K + ++D E + +E Q M L +P +V L + + ++++ Sbjct: 176 VTERATGNNF--AAKFVMTP-HESDKETVRKEIQTMSVLRHPTLVNLHDAFEDDNEMVMI 232 Query: 414 MEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNR- 472 E GG L + + + ++ E + QV G+ ++ E N+VH DL N++ + Sbjct: 233 YEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKR 292 Query: 473 -HYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWE 531 + K+ DFGL+ L S ++ APE + +D+WS GV + Sbjct: 293 SNELKLIDFGLTAHLDPKQSV----KVTTGTAEFAAPEVAEGKPVGYYTDMWSVGVLSYI 348 Query: 532 ALSYGQKPYKKMKGPEVMAFIEQ---GKRMECPPECPPELYALMSDCWIYKWEDRPDFLT 588 LS G P+ E + ++ + + + R Sbjct: 349 LLS-GLSPFGGENDDETLRNVKSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTRMT--- 404 Query: 589 VEQRMRACYYS 599 + Q + + + Sbjct: 405 IHQALEHPWLT 415 >6FDY-U nrPDB Length = 276 Score = 244 bits (624), Expect = 7e-65, Method: Composition-based stats. Identities = 69/267 (25%), Positives = 128/267 (47%), Gaps = 13/267 (4%) Query: 328 KKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTEEMMRE 386 R + I LG G + +V + + +++ VAIK + K+ KA E ++ E Sbjct: 3 PGWGPPRLDGFILTERLGSGTYATVYKAYAKKDTREV-VAIKCVAKKSLNKASVENLLTE 61 Query: 387 AQIMHQLDNPYIVRLIGV-CQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQV 445 +I+ + +P+IV+L ++ + L+ME GG L +F+ +R +P + Q+ Sbjct: 62 IEILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRR-ILPEKVARVFMQQL 120 Query: 446 SMGMKYLEEKNFVHRDLAARNVLLV--NRHYAKISDFGLSKALGADDSYYTARSAGKWPL 503 + +++L E+N H DL +N+LL + + K++DFG ++ + D + R + Sbjct: 121 ASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGS----P 176 Query: 504 KWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECP-- 561 + APE + R++ +R D+WS GV ++EAL +GQ P+ E+ I + +E P Sbjct: 177 LYMAPEMVCQRQYDARVDLWSMGVILYEAL-FGQPPFASRSFSELEEKIRSNRVIELPLR 235 Query: 562 PECPPELYALMSDCWIYKWEDRPDFLT 588 P + L+ R F Sbjct: 236 PLLSRDCRDLLQRLLERDPSRRISFQD 262 >5HI2-A nrPDB Length = 283 Score = 244 bits (622), Expect = 1e-64, Method: Composition-based stats. Identities = 64/283 (22%), Positives = 122/283 (43%), Gaps = 20/283 (7%) Query: 328 KKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREA 387 + D + +G G+FG+V +G + DVA+K+L + E Sbjct: 13 DDWEIP-DGQITVGQRIGSGSFGTVYKGKWHG-----DVAVKML----TPQQLQAFKNEV 62 Query: 388 QIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSM 447 ++ + + I+ +G L +V + G L+ L + + + ++ Q + Sbjct: 63 GVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTAR 122 Query: 448 GMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYA 507 GM YL K+ +HRDL + N+ L + KI DFGL+ + + W A Sbjct: 123 GMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQL-SGSILWMA 181 Query: 508 PECINFR---KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP-EVMAFIEQGKRME---- 559 PE I + +S +SDV+++G+ ++E ++ GQ PY + +++ + +G Sbjct: 182 PEVIRMQDSNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIEMVGRGSLSPDLSK 240 Query: 560 CPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLAS 602 CP + LM++C K ++RP F + + L+ Sbjct: 241 VRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELARELSG 283 >2BDW-A nrPDB Length = 362 Score = 243 bits (621), Expect = 1e-64, Method: Composition-based stats. Identities = 66/256 (25%), Positives = 118/256 (46%), Gaps = 15/256 (5%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 DN + + ELG G F VR+ V++ + I K+ + + D +++ REA+I +L Sbjct: 29 DNYDVKE-ELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSAR-DFQKLEREARICRKLQ 86 Query: 395 NPYIVRLIGVCQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 +P IVRL Q E+ LV ++ GG L + +V RE ++ + + Q+ + Y Sbjct: 87 HPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVA-REFYSEADASHCIQQILESIAYCH 145 Query: 454 EKNFVHRDLAARNVLLVNRHY---AKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510 VHR+L N+LL ++ K++DFGL+ + ++++ + +PE Sbjct: 146 SNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWH----GFAGTPGYLSPEV 201 Query: 511 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE---CPPE 567 + +S D+W+ GV ++ L G P+ + A I+ G PE PE Sbjct: 202 LKKDPYSKPVDIWACGVILYILL-VGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPE 260 Query: 568 LYALMSDCWIYKWEDR 583 +L+ + R Sbjct: 261 AKSLIDSMLTVNPKKR 276 >3KK8-A nrPDB Length = 284 Score = 242 bits (618), Expect = 3e-64, Method: Composition-based stats. Identities = 66/256 (25%), Positives = 118/256 (46%), Gaps = 15/256 (5%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 DN + + ELG G F VR+ V++ + I K+ + + D +++ REA+I +L Sbjct: 6 DNYDVKE-ELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSAR-DFQKLEREARICRKLQ 63 Query: 395 NPYIVRLIGVCQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 +P IVRL Q E+ LV ++ GG L + +V RE ++ + + Q+ + Y Sbjct: 64 HPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVA-REFYSEADASHCIQQILESIAYCH 122 Query: 454 EKNFVHRDLAARNVLLVNRHY---AKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510 VHR+L N+LL ++ K++DFGL+ + ++++ + +PE Sbjct: 123 SNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWH----GFAGTPGYLSPEV 178 Query: 511 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE---CPPE 567 + +S D+W+ GV ++ L G P+ + A I+ G PE PE Sbjct: 179 LKKDPYSKPVDIWACGVILYILL-VGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPE 237 Query: 568 LYALMSDCWIYKWEDR 583 +L+ + R Sbjct: 238 AKSLIDSMLTVNPKKR 253 >3MN3-A nrPDB Length = 271 Score = 241 bits (616), Expect = 5e-64, Method: Composition-based stats. Identities = 67/261 (25%), Positives = 116/261 (44%), Gaps = 15/261 (5%) Query: 336 NLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTE-EMMREAQIMHQL 393 N I LG G+FG V+ + VA+K++ K+ K+D + + RE + L Sbjct: 5 NYQIVKT-LGEGSFGKVKLAYH--TTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLL 61 Query: 394 DNPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYL 452 +P+I++L V ++ + +++V+E A G L ++V +R+++ Q+ ++Y Sbjct: 62 RHPHIIKLYDVIKSKDEIIMVIEYA-GNELFDYIV-QRDKMSEQEARRFFQQIISAVEYC 119 Query: 453 EEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN 512 VHRDL N+LL KI+DFGLS + + T+ + + APE I+ Sbjct: 120 HRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGS----PNYAAPEVIS 175 Query: 513 FRKF-SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYAL 571 + + DVWS GV ++ L + P+ P + I G P P L Sbjct: 176 GKLYAGPEVDVWSCGVILYVMLCR-RLPFDDESIPVLFKNISNGVY-TLPKFLSPGAAGL 233 Query: 572 MSDCWIYKWEDRPDFLTVEQR 592 + I +R + Q Sbjct: 234 IKRMLIVNPLNRISIHEIMQD 254 >5D9K-A nrPDB Length = 330 Score = 241 bits (614), Expect = 9e-64, Method: Composition-based stats. Identities = 76/269 (28%), Positives = 126/269 (46%), Gaps = 17/269 (6%) Query: 342 IELGCGNFGSVRQGVYRMRKK-QIDVAIKVLKQGTEK-ADTEEMMREAQIMHQLDNPYIV 399 LG G+FG V + A+KVLK+ T K D E I+ ++++P+IV Sbjct: 36 KVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIV 95 Query: 400 RLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 +L Q E L L+++ GG L L K +V L ++++ + +L + Sbjct: 96 KLHYAFQTEGKLYLILDFLRGGDLFTRL-SKEVMFTEEDVKFYLAELALALDHLHSLGII 154 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKA-LGADDSYYTARSAGKWPLKWYAPECINFRKFS 517 +RDL N+LL + K++DFGLSK + + Y+ +++ APE +N R + Sbjct: 155 YRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFC----GTVEYMAPEVVNRRGHT 210 Query: 518 SRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWI 577 +D WS+GV M+E L+ G P++ E M I + K + P PE +L+ + Sbjct: 211 QSADWWSFGVLMFEMLT-GTLPFQGKDRKETMTMILKAK-LGMPQFLSPEAQSLLRMLFK 268 Query: 578 YKWEDR----PDFLTVEQRMRACYYSLAS 602 +R PD VE+ R ++S Sbjct: 269 RNPANRLGAGPD--GVEEIKRHSFFSTID 295 >3LIJ-A nrPDB Length = 494 Score = 240 bits (613), Expect = 1e-63, Method: Composition-based stats. Identities = 66/264 (25%), Positives = 117/264 (44%), Gaps = 20/264 (7%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT-EKADTEEMMREAQIMHQLDNPYIVR 400 +LG G +G V ++ ++ AIK++++ + + +++ E ++ LD+P I++ Sbjct: 43 KKLGSGAYGEVLLCRDKVT--HVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLDHPNIMK 100 Query: 401 LIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 L + + LVME GG L ++ R + + A ++ QV G+ YL + N VH Sbjct: 101 LYDFFEDKRNYYLVMECYKGGELFDEII-HRMKFNEVDAAVIIKQVLSGVTYLHKHNIVH 159 Query: 460 RDLAARNVLLVN---RHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKF 516 RDL N+LL + KI DFGLS + APE + +K+ Sbjct: 160 RDLKPENLLLESKEKDALIKIVDFGLSAVFEN----QKKMKERLGTAYYIAPEVLR-KKY 214 Query: 517 SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE---CPPELYALMS 573 + DVWS GV ++ L+ G P+ E++ +E+GK PE L+ Sbjct: 215 DEKCDVWSIGVILFILLA-GYPPFGGQTDQEILRKVEKGKYTFDSPEWKNVSEGAKDLIK 273 Query: 574 DCWIYKWEDRPDFLTVEQRMRACY 597 + + R +Q + + Sbjct: 274 QMLQFDSQRRISA---QQALEHPW 294 >3OMV-A nrPDB Length = 307 Score = 240 bits (612), Expect = 1e-63, Method: Composition-based stats. Identities = 69/280 (24%), Positives = 127/280 (45%), Gaps = 17/280 (6%) Query: 330 LFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQ-GTEKADTEEMMREAQ 388 ++ ++++ +G G+FG+V +G + DVA+K+LK + E Sbjct: 31 WEIEASEVMLS-TRIGSGSFGTVYKGKWHG-----DVAVKILKVVDPTPEQFQAFRNEVA 84 Query: 389 IMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMG 448 ++ + + I+ +G + L +V + G L+K L + + + + ++ Q + G Sbjct: 85 VLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQG 144 Query: 449 MKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 M YL KN +HRD+ + N+ L KI DFGL+ L W AP Sbjct: 145 MDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVL-WMAP 203 Query: 509 ECINFR---KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP-EVMAFIEQGKRME----C 560 E I + FS +SDV+SYG+ ++E ++ G+ PY + +++ + +G Sbjct: 204 EVIRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRGYASPDLSKL 262 Query: 561 PPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL 600 CP + L++DC E+RP F + + +SL Sbjct: 263 YKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSL 302 >4CFH-A nrPDB Length = 493 Score = 240 bits (612), Expect = 1e-63, Method: Composition-based stats. Identities = 70/279 (25%), Positives = 116/279 (41%), Gaps = 11/279 (3%) Query: 316 ESPYSDPE-ELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG 374 E + P E + +K + ++ D LG G FG V+ G + + ++ V I ++ Sbjct: 13 EVLFQGPMAEKQKHDGRVKIGHYILGDT-LGVGTFGKVKVGKHELTGHKVAVKILNRQKI 71 Query: 375 TEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEI 433 ++ RE Q + +P+I++L V + + +VME GG L ++ K + Sbjct: 72 RSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYIC-KNGRL 130 Query: 434 PVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYY 493 L Q+ G+ Y VHRDL NVLL AKI+DFGLS + + Sbjct: 131 DEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR 190 Query: 494 TARSAGKWPLKWYAPECINFRKF-SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI 552 T+ + + APE I+ R + D+WS GV ++ L G P+ P + I Sbjct: 191 TSCGS----PNYAAPEVISGRLYAGPEVDIWSSGVILYALLC-GTLPFDDDHVPTLFKKI 245 Query: 553 EQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQ 591 G P P + +L+ R + + Sbjct: 246 CDGIFYT-PQYLNPSVISLLKHMLQVDPMKRATIKDIRE 283 >2HAK-A nrPDB Length = 328 Score = 240 bits (612), Expect = 1e-63, Method: Composition-based stats. Identities = 69/260 (26%), Positives = 113/260 (43%), Gaps = 13/260 (5%) Query: 336 NLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTEEMMREAQIMHQLD 394 N + +G GNF V+ + + ++ VA+K++ K +++ RE +IM L+ Sbjct: 16 NYRLQKT-IGKGNFAKVKLARHVLTGRE--VAVKIIDKTQLNPTSLQKLFREVRIMKILN 72 Query: 395 NPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 +P IV+L V + E L LVME A GG + +LV + Q+ ++Y Sbjct: 73 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAH-GRMKEKEARAKFRQIVSAVQYCH 131 Query: 454 EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF 513 +K VHRDL A N+LL KI+DFG S + T + + APE Sbjct: 132 QKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGS----PPYAAPELFQG 187 Query: 514 RKFS-SRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALM 572 +K+ DVWS GV ++ +S G P+ E+ + +GK P + L+ Sbjct: 188 KKYDGPEVDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRGKY-RIPFYMSTDCENLL 245 Query: 573 SDCWIYKWEDRPDFLTVEQR 592 + R + + Sbjct: 246 KKLLVLNPIKRGSLEQIMKD 265 >4QMW-A nrPDB Length = 310 Score = 240 bits (612), Expect = 2e-63, Method: Composition-based stats. Identities = 67/266 (25%), Positives = 123/266 (46%), Gaps = 9/266 (3%) Query: 327 DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMRE 386 + L + L ++G G+FG V +G+ +K VAIK++ + + E++ +E Sbjct: 20 MQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQK--VVAIKIIDLEEAEDEIEDIQQE 77 Query: 387 AQIMHQLDNPYIVRLIG-VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQV 445 ++ Q D+PY+ + G + L ++ME GGG L + + + +A +L ++ Sbjct: 78 ITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLL--EPGPLDETQIATILREI 135 Query: 446 SMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKW 505 G+ YL + +HRD+ A NVLL K++DFG++ L R+ W Sbjct: 136 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQI---KRNTFVGTPFW 192 Query: 506 YAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP 565 APE I + S++D+WS G+T E L+ G+ P+ ++ +V+ I + Sbjct: 193 MAPEVIKQSAYDSKADIWSLGITAIE-LARGEPPHSELHPMKVLFLIPKNNPPTLEGNYS 251 Query: 566 PELYALMSDCWIYKWEDRPDFLTVEQ 591 L + C + RP + + Sbjct: 252 KPLKEFVEACLNKEPSFRPTAKELLK 277 >2YZA-A nrPDB Length = 276 Score = 240 bits (612), Expect = 2e-63, Method: Composition-based stats. Identities = 66/270 (24%), Positives = 111/270 (41%), Gaps = 14/270 (5%) Query: 326 KDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKAD--TEEM 383 +K + ++ D LG G FG V+ G +++ + VA+K+L + ++ ++ Sbjct: 2 SKHDGRVKIGHYVLGDT-LGVGTFGKVKIGEHQLTGHK--VAVKILNRQKIRSLDVVGKI 58 Query: 384 MREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELL 442 RE Q + +P+I++L V +VME GG L ++ K + L Sbjct: 59 KREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC-KHGRVEEMEARRLF 117 Query: 443 HQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWP 502 Q+ + Y VHRDL NVLL AKI+DFGLS + + + + Sbjct: 118 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGS---- 173 Query: 503 LKWYAPECINFRKF-SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECP 561 + APE I+ R + D+WS GV ++ L G P+ P + I +G P Sbjct: 174 PNYAAPEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIP 231 Query: 562 PECPPELYALMSDCWIYKWEDRPDFLTVEQ 591 + L+ R + + Sbjct: 232 EYLNRSVATLLMHMLQVDPLKRATIKDIRE 261 >5HVK-A nrPDB Length = 315 Score = 240 bits (612), Expect = 2e-63, Method: Composition-based stats. Identities = 72/302 (23%), Positives = 126/302 (41%), Gaps = 30/302 (9%) Query: 326 KDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQ--GTEKADTEEM 383 + ++F D LI LG G FG + +R + + V+K+ ++ Sbjct: 6 RPHRIFRPSD--LIHGEVLGKGCFGQAIKVTHRETGE-----VMVMKELIRFDEETQRTF 58 Query: 384 MREAQIMHQLDNPYIVRLIGV-CQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELL 442 ++E ++M L++P +++ IGV + + L + E GG L + + P S Sbjct: 59 LKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFA 118 Query: 443 HQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSY---------- 492 ++ GM YL N +HR+L + N L+ ++DFGL++ + + + Sbjct: 119 KDIASGMAYLHSMNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKP 178 Query: 493 -YTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSY-----GQKPYKKMKGP 546 R W APE IN R + + DV+S+G+ + E + P G Sbjct: 179 DRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGL 238 Query: 547 EVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEG 606 V F+++ CPP CPP + + C E RP F+ +E + LA + Sbjct: 239 NVRGFLDR----YCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHLAGHLPL 294 Query: 607 PP 608 P Sbjct: 295 GP 296 >5FG8-A nrPDB Length = 285 Score = 240 bits (612), Expect = 2e-63, Method: Composition-based stats. Identities = 66/256 (25%), Positives = 113/256 (44%), Gaps = 14/256 (5%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 DN I + ELG G F V++ V + + I K+ T + D +++ REA+I +L Sbjct: 14 DNYDIKE-ELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTAR-DFQKLEREARICRKLH 71 Query: 395 NPYIVRLIGVCQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 +P IVRL Q E LV ++ GG L + +V RE ++ + + Q+ + + Sbjct: 72 HPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVA-REFYSEADASHCIQQILESVNHCH 130 Query: 454 EKNFVHRDLAARNVLLVNRHY---AKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510 + VHRDL N+LL ++ K++DFGL+ + D + + +PE Sbjct: 131 QNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAW---FGFAGTPGYLSPEV 187 Query: 511 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE---CPPE 567 + + D+W+ GV ++ L G P+ + + I+ G PE PE Sbjct: 188 LKKEPYGKSVDIWACGVILYILL-VGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPE 246 Query: 568 LYALMSDCWIYKWEDR 583 L++ R Sbjct: 247 AKNLINQMLTVNPNKR 262 >3H4J-B nrPDB Length = 336 Score = 239 bits (611), Expect = 2e-63, Method: Composition-based stats. Identities = 64/259 (24%), Positives = 110/259 (42%), Gaps = 14/259 (5%) Query: 338 LIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKAD--TEEMMREAQIMHQLDN 395 I LG G+FG V+ + K Q VA+K + + K + RE + L + Sbjct: 11 YIIRETLGEGSFGKVKLATH--YKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRH 68 Query: 396 PYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 454 P+I++L V +++V+E A GG L ++V K+ + Q+ ++Y Sbjct: 69 PHIIKLYDVITTPTDIVMVIEYA-GGELFDYIVEKK-RMTEDEGRRFFQQIICAIEYCHR 126 Query: 455 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR 514 VHRDL N+LL + KI+DFGLS + + T+ + + APE IN + Sbjct: 127 HKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGS----PNYAAPEVINGK 182 Query: 515 KF-SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMS 573 + DVWS G+ ++ L G+ P+ P + + + P P +L+ Sbjct: 183 LYAGPEVDVWSCGIVLYVML-VGRLPFDDEFIPNLFKKVNSCVYV-MPDFLSPGAQSLIR 240 Query: 574 DCWIYKWEDRPDFLTVEQR 592 + R + + Sbjct: 241 RMIVADPMQRITIQEIRRD 259 >4REW-A nrPDB Length = 540 Score = 239 bits (611), Expect = 2e-63, Method: Composition-based stats. Identities = 69/264 (26%), Positives = 115/264 (43%), Gaps = 14/264 (5%) Query: 332 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKAD--TEEMMREAQI 389 +K + ++ D LG G FG V+ G + + + VA+K+L + ++ ++ RE Q Sbjct: 3 VKIGHYILGDT-LGVGTFGKVKVGKHELTGHK--VAVKILNRQKIRSLDVVGKIRREIQN 59 Query: 390 MHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMG 448 + +P+I++L V + + +VME GG L ++ K + L Q+ G Sbjct: 60 LKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYIC-KNGRLDEKESRRLFQQILSG 118 Query: 449 MKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 + Y VHRDL NVLL AKI+DFGLS + + T+ + + AP Sbjct: 119 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGS----PNYAAP 174 Query: 509 ECINFRKF-SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPE 567 E I+ R + D+WS GV ++ L G P+ P + I G P P Sbjct: 175 EVISGRLYAGPEVDIWSSGVILYALLC-GTLPFDDDHVPTLFKKICDGIFYT-PQYLNPS 232 Query: 568 LYALMSDCWIYKWEDRPDFLTVEQ 591 + +L+ R + + Sbjct: 233 VISLLKHMLQVDPMKRASIKDIRE 256 >4RED-A nrPDB Length = 351 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 69/264 (26%), Positives = 114/264 (43%), Gaps = 14/264 (5%) Query: 332 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKAD--TEEMMREAQI 389 +K + ++ D LG G FG V+ G + + VA+K+L + ++ ++ RE Q Sbjct: 11 VKIGHYILGDT-LGVGTFGKVKVGKHELTGH--AVAVKILNRQKIRSLDVVGKIRREIQN 67 Query: 390 MHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMG 448 + +P+I++L V + + +VME GG L ++ K + L Q+ G Sbjct: 68 LKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYIC-KNGRLDEKESRRLFQQILSG 126 Query: 449 MKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 + Y VHRDL NVLL AKI+DFGLS + + T+ + + AP Sbjct: 127 VDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGS----PNYAAP 182 Query: 509 ECINFRKF-SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPE 567 E I+ R + D+WS GV ++ L G P+ P + I G P P Sbjct: 183 EVISGRLYAGPEVDIWSSGVILYALLC-GTLPFDDDHVPTLFKKICDGIFYT-PQYLNPS 240 Query: 568 LYALMSDCWIYKWEDRPDFLTVEQ 591 + +L+ R + + Sbjct: 241 VISLLKHMLQVDPMKRASIKDIRE 264 >5HIE-A nrPDB Length = 302 Score = 239 bits (610), Expect = 3e-63, Method: Composition-based stats. Identities = 65/281 (23%), Positives = 121/281 (43%), Gaps = 20/281 (7%) Query: 328 KKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREA 387 + D + +G G+FG+V +G + DVA+K+L + E Sbjct: 29 DDWEIP-DGQITVGQRIGSGSFGTVYKGKWHG-----DVAVKML----TPQQLQAFKNEV 78 Query: 388 QIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSM 447 ++ + + I+ +G L +V + G L+ L + + + ++ Q + Sbjct: 79 GVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQ 138 Query: 448 GMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYA 507 GM YL K+ +HRDL + N+ L KI DFGL+ + + W A Sbjct: 139 GMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL-SGSILWMA 197 Query: 508 PECINFR---KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP-EVMAFIEQGKRME---- 559 PE I + +S +SDV+++G+ ++E ++ GQ PY + +++ + +G Sbjct: 198 PEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSK 256 Query: 560 CPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL 600 CP + LM++C K ++RP F + + SL Sbjct: 257 VRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL 297 >4FG9-A nrPDB Length = 320 Score = 239 bits (610), Expect = 3e-63, Method: Composition-based stats. Identities = 70/281 (24%), Positives = 113/281 (40%), Gaps = 19/281 (6%) Query: 334 RDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL 393 RD D+ LG G F V + +K VAIK + + + M E ++H++ Sbjct: 17 RDIYDFRDV-LGTGAFSEVILAEDKRTQK--LVAIKCIAKEALEGKEGSMENEIAVLHKI 73 Query: 394 DNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYL 452 +P IV L + ++ L L+M++ GG L +V K + + L+ QV +KYL Sbjct: 74 KHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGF-YTERDASRLIFQVLDAVKYL 132 Query: 453 EEKNFVHRDLAARNVL---LVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPE 509 + VHRDL N+L L ISDFGLSK TA + APE Sbjct: 133 HDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTAC----GTPGYVAPE 188 Query: 510 CINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPP---ECPP 566 + + +S D WS GV + L G P+ ++ I + + P + Sbjct: 189 VLAQKPYSKAVDCWSIGVIAYILLC-GYPPFYDENDAKLFEQILKAEYEFDSPYWDDISD 247 Query: 567 ELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGP 607 + E R EQ ++ + + + ++ Sbjct: 248 SAKDFIRHLMEKDPEKRFT---CEQALQHPWIAGDTALDKN 285 >2V7O-A nrPDB Length = 336 Score = 239 bits (610), Expect = 3e-63, Method: Composition-based stats. Identities = 63/256 (24%), Positives = 115/256 (44%), Gaps = 14/256 (5%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 D+ + + ELG G F VR+ V + ++ I K+ + + D +++ REA+I L Sbjct: 31 DDYQLFE-ELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSAR-DHQKLEREARICRLLK 88 Query: 395 NPYIVRLIGVCQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 +P IVRL E LV ++ GG L + +V RE ++ + +HQ+ + ++ Sbjct: 89 HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVA-REYYSEADASHCIHQILESVNHIH 147 Query: 454 EKNFVHRDLAARNVLLVNRHY---AKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510 + + VHRDL N+LL ++ K++DFGL+ + + + + +PE Sbjct: 148 QHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAW---FGFAGTPGYLSPEV 204 Query: 511 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE---CPPE 567 + + D+W+ GV ++ L G P+ ++ I+ G PE PE Sbjct: 205 LRKDPYGKPVDIWACGVILYILL-VGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPE 263 Query: 568 LYALMSDCWIYKWEDR 583 L++ R Sbjct: 264 AKNLINQMLTINPAKR 279 >5VO2-A nrPDB Length = 300 Score = 239 bits (610), Expect = 3e-63, Method: Composition-based stats. Identities = 73/267 (27%), Positives = 118/267 (44%), Gaps = 21/267 (7%) Query: 330 LFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQI 389 + + +L +G G G+V G + +VA+K ++ E + Sbjct: 7 WEVPFEEILDLQW-VGSGAQGAVFLGRFHGE----EVAVKKVRDLKETD--------IKH 53 Query: 390 MHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMG 448 + +L +P I+ GVC QA ++ME G L++ L R P S + + ++ G Sbjct: 54 LRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTP-SLLVDWSMGIAGG 112 Query: 449 MKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 M YL +HRDL + N+L+ KISDFG SK L + + + W AP Sbjct: 113 MNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSF----AGTVAWMAP 168 Query: 509 ECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK-RMECPPECPPE 567 E I S + D+WS+GV +WE L+ G+ PYK + ++ + + P CP Sbjct: 169 EVIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDG 227 Query: 568 LYALMSDCWIYKWEDRPDFLTVEQRMR 594 L+ CW K +RP F + + Sbjct: 228 FKILLRQCWNSKPRNRPSFRQILLHLD 254 >2Z7Q-A nrPDB Length = 321 Score = 238 bits (608), Expect = 4e-63, Method: Composition-based stats. Identities = 77/269 (28%), Positives = 124/269 (46%), Gaps = 17/269 (6%) Query: 342 IELGCGNFGSVRQGVYRMR-KKQIDVAIKVLKQGTEK-ADTEEMMREAQIMHQLDNPYIV 399 LG G+FG V R A+KVLK+ T K D E I+ +++P++V Sbjct: 34 KVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVV 93 Query: 400 RLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 +L Q E L L+++ GG L L K +V L ++++G+ +L + Sbjct: 94 KLHYAFQTEGKLYLILDFLRGGDLFTRL-SKEVMFTEEDVKFYLAELALGLDHLHSLGII 152 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKA-LGADDSYYTARSAGKWPLKWYAPECINFRKFS 517 +RDL N+LL + K++DFGLSK + + Y+ +++ APE +N + S Sbjct: 153 YRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFC----GTVEYMAPEVVNRQGHS 208 Query: 518 SRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWI 577 +D WSYGV M+E L+ G P++ E M I + K + P E +L+ + Sbjct: 209 HSADWWSYGVLMFEMLT-GSLPFQGKDRKETMTLILKAK-LGMPQFLSTEAQSLLRALFK 266 Query: 578 YKWEDR----PDFLTVEQRMRACYYSLAS 602 +R PD E+ R +YS Sbjct: 267 RNPANRLGSGPD--GAEEIKRHVFYSTID 293 >4D28-A nrPDB Length = 446 Score = 238 bits (607), Expect = 5e-63, Method: Composition-based stats. Identities = 67/265 (25%), Positives = 118/265 (44%), Gaps = 12/265 (4%) Query: 332 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQI 389 ++R +G G F V+ R +VAIK++ + T + +++ RE I Sbjct: 5 MRRVGKYEVGRTIGEGTFAKVKFA--RNTDTGDNVAIKIMAKSTILKNRMVDQIKREISI 62 Query: 390 MHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMG 448 M + +P IVRL V +++ + +V+E GG L +V K + + Q+ Sbjct: 63 MKIVRHPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHK-GRLKEDESRKYFQQLVDA 121 Query: 449 MKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 + + K HRDL N+LL K+SDFGLS AL + + G + AP Sbjct: 122 VAHCHSKGVYHRDLKPENLLLDTNGNLKVSDFGLS-ALPQEGVELLNDTCG--TPNYVAP 178 Query: 509 ECINFRKFS-SRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPE 567 E ++ + + S +D+WS GV ++ L+ G P+ + P + I + +CPP E Sbjct: 179 EVLSGQGYDGSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKINAAE-FDCPPWFSAE 236 Query: 568 LYALMSDCWIYKWEDRPDFLTVEQR 592 + L+ + R +++ Sbjct: 237 VKFLIHRILDPNPKTRIQIQGIKKD 261 >6C9D-A nrPDB Length = 459 Score = 237 bits (606), Expect = 8e-63, Method: Composition-based stats. Identities = 68/260 (26%), Positives = 112/260 (43%), Gaps = 13/260 (5%) Query: 336 NLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTEEMMREAQIMHQLD 394 N + +G GNF V+ + + ++ VA+K++ K +++ RE +IM L+ Sbjct: 22 NYRLQKT-IGKGNFAKVKLARHVLTGRE--VAVKIIDKTQLNPTSLQKLFREVRIMKILN 78 Query: 395 NPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 +P IV+L V + E L LVME A GG + +LV + Q+ ++Y Sbjct: 79 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAH-GRMKEKEARAKFRQIVSAVQYCH 137 Query: 454 EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF 513 +K VHRDL A N+LL KI+DFG S + + + APE Sbjct: 138 QKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGS----PPYAAPELFQG 193 Query: 514 RKFS-SRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALM 572 +K+ DVWS GV ++ +S G P+ E+ + +GK P + L+ Sbjct: 194 KKYDGPEVDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRGKY-RIPFYMSTDCENLL 251 Query: 573 SDCWIYKWEDRPDFLTVEQR 592 + R + + Sbjct: 252 KKLLVLNPIKRGSLEQIMKD 271 >5XZW-A nrPDB Length = 471 Score = 237 bits (606), Expect = 9e-63, Method: Composition-based stats. Identities = 75/303 (24%), Positives = 126/303 (41%), Gaps = 31/303 (10%) Query: 303 DKPRPMPMDTSVYESP---YSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRM 359 D+ R +TS SP S + K + +D I D +G G F +V++ + R Sbjct: 161 DRIRSNLKNTSKIASPGLTSSTASSMVANKTGIFKD-FSIIDEVVGQGAFATVKKAIERT 219 Query: 360 RKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQA-EALMLVMEMAG 418 K A+K++ + + + + RE +++ +L++P IVRL G + E+ +VME Sbjct: 220 TGK--TFAVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGFYEDTESYYMVMEFVS 277 Query: 419 GGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRH--YAK 476 GG L F+ + E+ Q+ +KY+ HRDL N+L+ K Sbjct: 278 GGDLMDFVAAH-GAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDPVLVK 336 Query: 477 ISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR-------------KFSSRSDVW 523 I+DFGL+K G T L + APE I + ++SS D+W Sbjct: 337 ITDFGLAKVQGNGSFMKTFC----GTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMW 392 Query: 524 SYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE---CPPELYALMSDCWIYKW 580 S G ++ L+ G P+ ++ I +G E P + E + Sbjct: 393 SMGCLVYVILT-GHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDP 451 Query: 581 EDR 583 +R Sbjct: 452 NNR 454 >3COM-A nrPDB Length = 314 Score = 237 bits (604), Expect = 1e-62, Method: Composition-based stats. Identities = 68/277 (24%), Positives = 125/277 (45%), Gaps = 12/277 (4%) Query: 318 PYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEK 377 P ++L + L + + + +LG G++GSV + +++ + VAIK + + Sbjct: 11 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQ--IVAIKQVPV---E 65 Query: 378 ADTEEMMREAQIMHQLDNPYIVRLIG-VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVS 436 +D +E+++E IM Q D+P++V+ G + L +VME G G + + + + + Sbjct: 66 SDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTED 125 Query: 437 NVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTAR 496 +A +L G++YL +HRD+ A N+LL +AK++DFG++ L R Sbjct: 126 EIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDT---MAKR 182 Query: 497 SAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK 556 + W APE I ++ +D+WS G+T E + G+ PY + + I Sbjct: 183 NTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEM-AEGKPPYADIHPMRAIFMIPTNP 241 Query: 557 RMEC--PPECPPELYALMSDCWIYKWEDRPDFLTVEQ 591 P + C + E R + Q Sbjct: 242 PPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQ 278 >2VN9-A nrPDB Length = 301 Score = 236 bits (603), Expect = 2e-62, Method: Composition-based stats. Identities = 64/277 (23%), Positives = 113/277 (40%), Gaps = 14/277 (5%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 D + + ELG G F VR+ + ++ I K+ + + D +++ REA+I L Sbjct: 4 DEYQLFE-ELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSAR-DHQKLEREARICRLLK 61 Query: 395 NPYIVRLIGVCQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 +P IVRL E LV ++ GG L + +V RE ++ + + Q+ + + Sbjct: 62 HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVA-REYYSEADASHCIQQILESVNHCH 120 Query: 454 EKNFVHRDLAARNVLLVNRHY---AKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510 VHRDL N+LL ++ K++DFGL+ + D + + +PE Sbjct: 121 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAW---FGFAGTPGYLSPEV 177 Query: 511 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE---CPPE 567 + + D+W+ GV ++ L G P+ + I+ G PE PE Sbjct: 178 LRKDPYGKPVDMWACGVILYILL-VGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPE 236 Query: 568 LYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKV 604 L++ R + C S + + Sbjct: 237 AKDLINKMLTINPAKRITASEALKHPWICQRSTVASM 273 >4WNO-A nrPDB Length = 287 Score = 236 bits (603), Expect = 2e-62, Method: Composition-based stats. Identities = 70/272 (25%), Positives = 122/272 (44%), Gaps = 25/272 (9%) Query: 329 KLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQ 388 K R +L +G G F V +G +R ++VA+K + + + +E + Sbjct: 17 KFEFSRKDL------IGHGAFAVVFKGRHRA-AHDLEVAVKCINKKNLAKSQTLLGKEIK 69 Query: 389 IMHQLDNPYIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSM 447 I+ +L + IV L + A ++ LVME GG L +L R + + L Q++ Sbjct: 70 ILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMR-TLSEDTIRLFLQQIAG 128 Query: 448 GMKYLEEKNFVHRDLAARNVLLVNRH---------YAKISDFGLSKALGADDSYYTARSA 498 M+ L K +HRDL +N+LL N KI+DFG ++ L ++ T + Sbjct: 129 AMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGS 188 Query: 499 GKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM 558 + APE I + + ++D+WS G +++ L+ G+ P++ ++ F E+ K + Sbjct: 189 ----PMYMAPEVIMSQHYDGKADLWSIGTIVYQCLT-GKAPFQASSPQDLRLFYEKNKTL 243 Query: 559 --ECPPECPPELYALMSDCWIYKWEDRPDFLT 588 P E L L+ +DR DF Sbjct: 244 VPTIPRETSAPLRQLLLALLQRNHKDRMDFDE 275 >2XIK-A nrPDB Length = 294 Score = 236 bits (601), Expect = 3e-62, Method: Composition-based stats. Identities = 67/268 (25%), Positives = 120/268 (44%), Gaps = 9/268 (3%) Query: 325 LKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMM 384 ++ + + L +G G+FG V +G+ K+ VAIK++ + + E++ Sbjct: 8 FANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKE--VVAIKIIDLEEAEDEIEDIQ 65 Query: 385 REAQIMHQLDNPYIVRLIG-VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLH 443 +E ++ Q D+PYI R G ++ L ++ME GGG L K + + +A +L Sbjct: 66 QEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLL--KPGPLEETYIATILR 123 Query: 444 QVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPL 503 ++ G+ YL + +HRD+ A NVLL + K++DFG++ L R+ Sbjct: 124 EILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQI---KRNTFVGTP 180 Query: 504 KWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE 563 W APE I + ++D+WS G+T E L+ G+ P + V+ I + + Sbjct: 181 FWMAPEVIKQSAYDFKADIWSLGITAIE-LAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQ 239 Query: 564 CPPELYALMSDCWIYKWEDRPDFLTVEQ 591 + C RP + + Sbjct: 240 HSKPFKEFVEACLNKDPRFRPTAKELLK 267 >5YKS-A nrPDB Length = 377 Score = 235 bits (599), Expect = 5e-62, Method: Composition-based stats. Identities = 68/286 (23%), Positives = 120/286 (41%), Gaps = 14/286 (4%) Query: 336 NLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTEEMMREAQIMHQLD 394 L D LG G+F V+ + ++ VA+KV+ K + T + +E + M + Sbjct: 35 GLYDLDKTLGRGHFAVVKLARHVFTGEK--VAVKVIDKTKLDTLATGHLFQEVRCMKLVQ 92 Query: 395 NPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 +P IVRL V + L L++E+ GG + +++ E + + Q+ + Y Sbjct: 93 HPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCH 152 Query: 454 EKNFVHRDLAARN-VLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN 512 + + VHRDL N V + K++DFG S T+ + L + APE + Sbjct: 153 KLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGS----LAYSAPEILL 208 Query: 513 FRKFSS-RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYAL 571 ++ + D+WS GV ++ L GQ P+++ E + I K P E L Sbjct: 209 GDEYDAPAVDIWSLGVILF-MLVCGQPPFQEANDSETLTMIMDCKY-TVPSHVSKECKDL 266 Query: 572 MSDCWIYKWEDRPDFLTVEQ--RMRACYYSLASKVEGPPGSTQKAE 615 ++ + R +E ++ S A+K P S + Sbjct: 267 ITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYKNLS 312 >4FZF-B nrPDB Length = 283 Score = 234 bits (598), Expect = 6e-62, Method: Composition-based stats. Identities = 64/258 (24%), Positives = 112/258 (43%), Gaps = 9/258 (3%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 + L +G G+FG V +G+ + Q VAIK++ + + E++ +E ++ Q D Sbjct: 7 EELFTKLERIGKGSFGEVFKGIDN--RTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 64 Query: 395 NPYIVRLIG-VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 + Y+ + G + L ++ME GGG L +A +L ++ G+ YL Sbjct: 65 SSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA--GPFDEFQIATMLKEILKGLDYLH 122 Query: 454 EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF 513 + +HRD+ A NVLL + K++ FG++ L R+ W APE I Sbjct: 123 SEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQI---KRNTFVGTPFWMAPEVIQQ 179 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMS 573 + S++D+WS G+T E L+ G+ P M V+ I + + + Sbjct: 180 SAYDSKADIWSLGITAIE-LAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFID 238 Query: 574 DCWIYKWEDRPDFLTVEQ 591 C RP + + Sbjct: 239 ACLNKDPSFRPTAKELLK 256 >4CZT-A nrPDB Length = 464 Score = 234 bits (598), Expect = 6e-62, Method: Composition-based stats. Identities = 60/252 (23%), Positives = 103/252 (40%), Gaps = 10/252 (3%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQIMHQLDNPYIVRL 401 LG G F V+ R + +VAIKV+ + + ++ RE M + +P ++R+ Sbjct: 19 LGEGTFAKVKFA--RNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRM 76 Query: 402 IGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 V ++ + V+E GG L + + + Q+ + Y + HR Sbjct: 77 FEVMASKTKIYFVLEFVTGGELFDKI-SSNGRLKEDEARKYFQQLINAVDYCHSRGVYHR 135 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFS-SR 519 DL N+LL K+SDFGLS AL + APE IN + + ++ Sbjct: 136 DLKPENLLLDANGALKVSDFGLS-ALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAK 194 Query: 520 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYK 579 +D+WS GV ++ ++ G P++ + I + + CPP L+ Sbjct: 195 ADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKAE-FTCPPWFSASAKKLIKRILDPN 252 Query: 580 WEDRPDFLTVEQ 591 R F V + Sbjct: 253 PATRITFAEVIE 264 >2JC6-A nrPDB Length = 334 Score = 234 bits (598), Expect = 6e-62, Method: Composition-based stats. Identities = 65/275 (23%), Positives = 103/275 (37%), Gaps = 18/275 (6%) Query: 340 ADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIV 399 LG G F V + K A+K + + K + E ++ ++ + IV Sbjct: 26 FKETLGTGAFSEVVLAEEKATGK--LFAVKCIPKKALKGKESSIENEIAVLRKIKHENIV 83 Query: 400 RLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 L + ++ L LVM++ GG L +V K + + L+ QV + YL V Sbjct: 84 ALEDIYESPNHLYLVMQLVSGGELFDRIVEKGF-YTEKDASTLIRQVLDAVYYLHRMGIV 142 Query: 459 HRDLAARNVLL---VNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK 515 HRDL N+L ISDFGLSK G D TA + APE + + Sbjct: 143 HRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTAC----GTPGYVAPEVLAQKP 198 Query: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPP---ECPPELYALM 572 +S D WS GV + L G P+ ++ I + + P + + Sbjct: 199 YSKAVDCWSIGVIAYILLC-GYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFI 257 Query: 573 SDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGP 607 + R T EQ R + + + + Sbjct: 258 RNLMEKDPNKR---YTCEQAARHPWIAGDTALNKN 289 >6QAU-A nrPDB Length = 280 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 69/266 (25%), Positives = 122/266 (45%), Gaps = 20/266 (7%) Query: 336 NLLIADIEL-GCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 + + +L G G F V +G +R K +VAIK + + + +E +I+ +L Sbjct: 10 DFEYSKRDLVGHGAFAVVFRGRHRQ-KTDWEVAIKSINKKNLSKSQILLGKEIKILKELQ 68 Query: 395 NPYIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 + IV L V + ++ LVME GG L +L K + + LHQ++ M+ L Sbjct: 69 HENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAK-GTLSEDTIRVFLHQIAAAMRILH 127 Query: 454 EKNFVHRDLAARNVLLV---------NRHYAKISDFGLSKALGADDSYYTARSAGKWPLK 504 K +HRDL +N+LL + KI+DFG ++ L ++ + Sbjct: 128 SKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGS----PM 183 Query: 505 WYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM--ECPP 562 + APE I + + +++D+WS G +++ L G+ P++ ++ F E+ + + P Sbjct: 184 YMAPEVIMSQHYDAKADLWSIGTVIYQCL-VGKPPFQANSPQDLRMFYEKNRSLMPSIPR 242 Query: 563 ECPPELYALMSDCWIYKWEDRPDFLT 588 E P L L+ +DR DF Sbjct: 243 ETSPYLANLLLGLLQRNQKDRMDFEA 268 >3BHH-A nrPDB Length = 295 Score = 233 bits (594), Expect = 2e-61, Method: Composition-based stats. Identities = 61/270 (22%), Positives = 114/270 (42%), Gaps = 17/270 (6%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 D + + ++G G F VR+ V + I K+ + + D +++ REA+I L Sbjct: 4 DEYQLYE-DIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSAR-DHQKLEREARICRLLK 61 Query: 395 NPYIVRLIGVCQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 + IVRL E LV ++ GG L + +V RE ++ + + Q+ + + Sbjct: 62 HSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVA-REYYSEADASHCIQQILEAVLHCH 120 Query: 454 EKNFVHRDLAARNVLLVNRHY---AKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510 + VHRDL N+LL ++ K++DFGL+ + D + + +PE Sbjct: 121 QMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAW---FGFAGTPGYLSPEV 177 Query: 511 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE---CPPE 567 + + D+W+ GV ++ L G P+ ++ I+ G PE PE Sbjct: 178 LRKEAYGKPVDIWACGVILYILL-VGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPE 236 Query: 568 LYALMSDCWIYKWEDRPDFLTVEQRMRACY 597 L++ R +T + ++ + Sbjct: 237 AKNLINQMLTINPAKR---ITAHEALKHPW 263 >4RGJ-A nrPDB Length = 520 Score = 232 bits (593), Expect = 3e-61, Method: Composition-based stats. Identities = 61/275 (22%), Positives = 114/275 (41%), Gaps = 20/275 (7%) Query: 327 DKKLFLKRDNLLIAD-----IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTE 381 +F++ N++ + LG G+FG V + + + + K K D E Sbjct: 46 RPGMFIQNSNVVFNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKE 105 Query: 382 EMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAE 440 ++RE +++ LD+ I++L + LV ++ GG L ++ ++ + A Sbjct: 106 SLLREVELLKMLDHINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFY-EIDAAR 164 Query: 441 LLHQVSMGMKYLEEKNFVHRDLAARNVLL----VNRHYAKISDFGLSKALGADDSYYTAR 496 ++ Q+ G+ Y+ + N VHRDL N+LL KI DFGLS Y Sbjct: 165 IIKQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHF----EYSKKM 220 Query: 497 SAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK 556 + AP+ ++ + + D+WS GV ++ LS G P+ +++ +E GK Sbjct: 221 KDKIGTAYYIAPDVLHGT-YDEKCDIWSCGVILYILLS-GCPPFNGSNEYDILKKVEAGK 278 Query: 557 R---MECPPECPPELYALMSDCWIYKWEDRPDFLT 588 + + + L+ +Y R Sbjct: 279 YTFDLPQFKKISDKAKDLIKKMLMYTSAVRISARD 313 >6FD3-A nrPDB Length = 300 Score = 232 bits (592), Expect = 4e-61, Method: Composition-based stats. Identities = 57/279 (20%), Positives = 108/279 (38%), Gaps = 19/279 (6%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ++G G G+V + ++ VAIK + + E ++ E +M + NP IV + Sbjct: 29 KIGQGASGTVYTALDIATGQE--VAIKQMNLQQQPKK-ELIINEILVMRENKNPNIVNYL 85 Query: 403 G-VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 + L +VME GG L + + +A + + + +L +HRD Sbjct: 86 DSYLVGDELWVVMEYLAGGSLTDVVTET--CMDEGQIAAVCRECLQALDFLHSNQVIHRD 143 Query: 462 LAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSD 521 + + N+LL K++DFG + + + RS W APE + + + + D Sbjct: 144 IKSDNILLGMDGSVKLTDFGFCAQITPE---QSKRSTMVGTPYWMAPEVVTRKAYGPKVD 200 Query: 522 VWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMEC--PPECPPELYALMSDCWIYK 579 +WS G+ E + G+ PY + I E P ++ C Sbjct: 201 IWSLGIMAIEMV-EGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMD 259 Query: 580 WEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKAEAAC 618 + R + ++ ++ + K++ P S A Sbjct: 260 VDRR---GSAKELLQHPFL----KLDKPLSSLTPLIIAA 291 >3IS5-A nrPDB Length = 285 Score = 232 bits (592), Expect = 4e-61, Method: Composition-based stats. Identities = 70/267 (26%), Positives = 116/267 (43%), Gaps = 19/267 (7%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 D+L I +LG G FG V R + IK + + + E++ E +++ LD Sbjct: 21 DDLFIFKRKLGSGAFGDVHLVEERSSGLERV--IKTINKDRSQVPMEQIEAEIEVLKSLD 78 Query: 395 NPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVG---KREEIPVSNVAELLHQVSMGMK 450 +P I+++ V + + +VME GG L + +V + + + VAEL+ Q+ + Sbjct: 79 HPNIIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALA 138 Query: 451 YLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYA 507 Y ++ VH+DL N+L + KI DFGL++ +D+ + + A Sbjct: 139 YFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHS----TNAAGTALYMA 194 Query: 508 PECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI---EQGKRMECPPEC 564 PE R + + D+WS GV M+ L+ G P+ EV E +EC P Sbjct: 195 PEVFK-RDVTFKCDIWSAGVVMYFLLT-GCLPFTGTSLEEVQQKATYKEPNYAVECRPLT 252 Query: 565 PPELYALMSDCWIYKWEDRPDFLTVEQ 591 P + L+ E RP V Sbjct: 253 PQAV-DLLKQMLTKDPERRPSAAQVLH 278 >2WQN-A nrPDB Length = 310 Score = 232 bits (591), Expect = 4e-61, Method: Composition-based stats. Identities = 65/303 (21%), Positives = 123/303 (40%), Gaps = 18/303 (5%) Query: 306 RPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQID 365 P P++ + + ++G G F V + + + Sbjct: 2 DEQSQGMQGPPVPQFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRAACLL--DGVP 59 Query: 366 VAIKVLK--QGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPL 422 VA+K ++ + + ++E ++ QL++P +++ + L +V+E+A G L Sbjct: 60 VALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDL 119 Query: 423 H---KFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISD 479 K ++ IP V + Q+ ++++ + +HRD+ NV + K+ D Sbjct: 120 SRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGD 179 Query: 480 FGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKP 539 GL + S TA + + +PE I+ ++ +SD+WS G ++E + Q P Sbjct: 180 LGLGRFFS---SKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAAL-QSP 235 Query: 540 YKK--MKGPEVMAFIEQGKRMECPPE-CPPELYALMSDCWIYKWEDRPDFLTVE---QRM 593 + M + IEQ P + EL L++ C E RPD V +RM Sbjct: 236 FYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYVYDVAKRM 295 Query: 594 RAC 596 AC Sbjct: 296 HAC 298 >4CQG-A nrPDB Length = 331 Score = 232 bits (591), Expect = 4e-61, Method: Composition-based stats. Identities = 56/250 (22%), Positives = 104/250 (41%), Gaps = 9/250 (3%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G G F V+ + + + VAIK++ + +D + E + L + +I +L Sbjct: 17 IGTGGFAKVKLACHVLTGEM--VAIKIMDKNALGSDLPRVKTEIDALKSLRHQHICQLYH 74 Query: 404 VCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 V + + + +V+E GG L +++ + + + Q+ + Y+ + + HRDL Sbjct: 75 VLETKNKIFMVLEYCPGGELFDYIISQD-RLSEEETRVVFRQILSAVAYVHSQGYAHRDL 133 Query: 463 AARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKF-SSRSD 521 N+L H K+ DFGL + Y+ G L + APE I + + S +D Sbjct: 134 KPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGS--LAYAAPELIQGKSYLGSEAD 191 Query: 522 VWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWE 581 VWS G+ ++ + G P+ + I +GK E P P L+ + Sbjct: 192 VWSMGILLYVLMC-GFLPFDDDNVMALYKKIMRGKY-EVPKWLSPSSILLLQQMLQVDPK 249 Query: 582 DRPDFLTVEQ 591 R + Sbjct: 250 KRISMRNLLN 259 >4NEU-A nrPDB Length = 333 Score = 231 bits (590), Expect = 5e-61, Method: Composition-based stats. Identities = 85/309 (27%), Positives = 145/309 (46%), Gaps = 25/309 (8%) Query: 324 ELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADT-EE 382 ++ + +K + + EL G FG V +R + I +K + +G + E Sbjct: 13 DMSLNVIKMKSSDF-LESAELDSGGFGKVSLCFHRTQGLMI---MKTVYKGPNCIEHNEA 68 Query: 383 MMREAQIMHQLDNPYIVRLIGVCQAEALM-LVMEMAGGGPLHKFLVGKREEIPVSNVAEL 441 ++ EA++M++L + +V+L+GV E LVME G L L + P+S + Sbjct: 69 LLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMST-PLSVKGRI 127 Query: 442 LHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLS-----KALGADDSYYTAR 496 + ++ GM YL K +H+DL N+L+ N + KI+D GL+ L ++ Sbjct: 128 ILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELRE 187 Query: 497 SAG-----KWPLKWYAPECIN--FRKFSSRSDVWSYGVTMWEALSYGQKPYKK-MKGPEV 548 G L + APE +N K + +SDV+S+ V +W + ++PY+ + ++ Sbjct: 188 VDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFAN-KEPYENAICEQQL 246 Query: 549 MAFIEQGKRM---ECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYS-LASKV 604 + I+ G R + CP E+ +LM CW E RP F +E++ R Y S L V Sbjct: 247 IMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESV 306 Query: 605 EGPPGSTQK 613 E S +K Sbjct: 307 EEDVKSLKK 315 >5U6Y-A nrPDB Length = 461 Score = 231 bits (590), Expect = 6e-61, Method: Composition-based stats. Identities = 64/269 (23%), Positives = 116/269 (43%), Gaps = 16/269 (5%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ELG G F VR+ V + ++ I K+ + + D +++ REA+I L +P IVRL Sbjct: 7 ELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSAR-DHQKLEREARICRLLKHPNIVRLH 65 Query: 403 GVCQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 E L+ ++ GG L + +V RE ++ + + Q+ + + + VHRD Sbjct: 66 DSISEEGHHYLIFDLVTGGELFEDIVA-REYYSEADASHCIQQILEAVLHCHQMGVVHRD 124 Query: 462 LAARNVLLVNRHY---AKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 L N+LL ++ K++DFGL+ + + + + +PE + + Sbjct: 125 LKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAW---FGFAGTPGYLSPEVLRKDPYGK 181 Query: 519 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE---CPPELYALMSDC 575 D+W+ GV ++ L G P+ + I+ G PE PE L++ Sbjct: 182 PVDLWACGVILYILL-VGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKM 240 Query: 576 WIYKWEDRPDFLTVEQRMRACYYSLASKV 604 R +T + ++ + S S V Sbjct: 241 LTINPSKR---ITAAEALKHPWISHRSTV 266 >4RA4-A nrPDB Length = 355 Score = 231 bits (589), Expect = 7e-61, Method: Composition-based stats. Identities = 69/271 (25%), Positives = 121/271 (44%), Gaps = 13/271 (4%) Query: 317 SPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG-- 374 SP D ++ + +K + + LG G+FG V + + AIK+LK+ Sbjct: 2 SPSEDRKQPSNNLDRVKLTDFNFL-MVLGKGSFGKVMLA--DRKGTEELYAIKILKKDVV 58 Query: 375 TEKADTEEMMREAQIMHQLDNP-YIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREE 432 + D E M E +++ LD P ++ +L Q + L VME GG L + + + + Sbjct: 59 IQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLM-YHIQQVGK 117 Query: 433 IPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSY 492 ++S+G+ +L ++ ++RDL NV+L + + KI+DFG+ K D Sbjct: 118 FKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDG-- 175 Query: 493 YTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI 552 T R+ P + APE I ++ + D W+YGV ++E L+ GQ P+ E+ I Sbjct: 176 VTTRTFCGTP-DYIAPEIIAYQPYGKSVDWWAYGVLLYEMLA-GQPPFDGEDEDELFQSI 233 Query: 553 EQGKRMECPPECPPELYALMSDCWIYKWEDR 583 + + P E ++ R Sbjct: 234 ME-HNVSYPKSLSKEAVSICKGLMTKHPAKR 263 >5DYK-A nrPDB Length = 853 Score = 231 bits (588), Expect = 9e-61, Method: Composition-based stats. Identities = 75/334 (22%), Positives = 138/334 (41%), Gaps = 38/334 (11%) Query: 274 PSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPM------------DTSVYESPYSD 321 + ++R+ TL + Y E A + D+PR + D SV+ Sbjct: 462 EVEIVKNKKRLRTLGKNDYFGERALLY--DEPRTASVISKVNNVECWFVDKSVFLQIIQG 519 Query: 322 P------EELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT 375 P E +K + ++ D L I +G G FG+V+ ++ K I A+K + + + Sbjct: 520 PMLAHLEERIKMQDTKVEMDELETERI-IGRGTFGTVKLVHHKPTK--IRYALKCVSKRS 576 Query: 376 --EKADTEEMMREAQIMHQLDNPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREE 432 + E +I + D+P+I+RL+ + + + E+ GG L+ + K Sbjct: 577 IINLNQQNNIKLEREITAENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIR-KLGL 635 Query: 433 IPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSY 492 + S L + + ++YL E+N V+RDL N+LL + Y K+ DFG +K + Sbjct: 636 LSKSQAQFYLGSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQG---- 691 Query: 493 YTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY--KKMKGPEVMA 550 + APE I + + D+W+ G+ ++E + G P+ + E+ Sbjct: 692 --RAYTLVGTPHYMAPEVILGKGYGCTVDIWALGICLYEFIC-GPLPFGNDEEDQLEIFR 748 Query: 551 FIEQGKRMECPPECPP-ELYALMSDCWIYKWEDR 583 I G ++ P + LM + R Sbjct: 749 DILTG-QLTFPDYVTDTDSINLMKRLLCRLPQGR 781 >1FOT-A nrPDB Length = 318 Score = 231 bits (588), Expect = 9e-61, Method: Composition-based stats. Identities = 60/243 (24%), Positives = 106/243 (43%), Gaps = 14/243 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQIMHQLDNPYIVRL 401 LG G+FG V R R A+KVLK+ E E ++ + +P+I+R+ Sbjct: 14 LGTGSFGRVHL--IRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRM 71 Query: 402 IGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 G Q + + ++M+ GG L L K + P +V + ++YL K+ ++R Sbjct: 72 WGTFQDAQQIFMIMDYIEGGELFSLLR-KSQRFPNPVAKFYAAEVCLALEYLHSKDIIYR 130 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRS 520 DL N+LL + KI+DFG +K + + APE ++ + ++ Sbjct: 131 DLKPENILLDKNGHIKITDFGFAKYVPD------VTYTLCGTPDYIAPEVVSTKPYNKSI 184 Query: 521 DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKW 580 D WS+G+ ++E L+ G P+ + I + + PP ++ L+S Sbjct: 185 DWWSFGILIYEMLA-GYTPFYDSNTMKTYEKILNAE-LRFPPFFNEDVKDLLSRLITRDL 242 Query: 581 EDR 583 R Sbjct: 243 SQR 245 >2JDO-A nrPDB Length = 342 Score = 231 bits (588), Expect = 1e-60, Method: Composition-based stats. Identities = 59/260 (22%), Positives = 108/260 (41%), Gaps = 14/260 (5%) Query: 327 DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG--TEKADTEEMM 384 D K+ + + L LG G FG V + + A+K+L++ K + + Sbjct: 4 DPKVTMNDFDYLKL---LGKGTFGKVILVREKATGR--YYAMKILRKEVIIAKDEVAHTV 58 Query: 385 REAQIMHQLDNPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLH 443 E++++ +P++ L Q + L VME A GG L L +R Sbjct: 59 TESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRER-VFTEERARFYGA 117 Query: 444 QVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPL 503 ++ ++YL ++ V+RD+ N++L + KI+DFGL K +D + Sbjct: 118 EIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTF---CGTP 174 Query: 504 KWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE 563 ++ APE + + D W GV M+E + G+ P+ + I + + P Sbjct: 175 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHERLFELILM-EEIRFPRT 232 Query: 564 CPPELYALMSDCWIYKWEDR 583 PE +L++ + R Sbjct: 233 LSPEAKSLLAGLLKKDPKQR 252 >2VZ6-A nrPDB Length = 313 Score = 230 bits (587), Expect = 1e-60, Method: Composition-based stats. Identities = 64/269 (23%), Positives = 116/269 (43%), Gaps = 16/269 (5%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ELG G F VR+ V + ++ I K+ + + D +++ REA+I L +P IVRL Sbjct: 29 ELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSAR-DHQKLEREARICRLLKHPNIVRLH 87 Query: 403 GVCQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 E L+ ++ GG L + +V RE ++ + + Q+ + + + VHRD Sbjct: 88 DSISEEGHHYLIFDLVTGGELFEDIVA-REYYSEADASHCIQQILEAVLHCHQMGVVHRD 146 Query: 462 LAARNVLLVNRHY---AKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 L N+LL ++ K++DFGL+ + + + + +PE + + Sbjct: 147 LKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAW---FGFAGTPGYLSPEVLRKDPYGK 203 Query: 519 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE---CPPELYALMSDC 575 D+W+ GV ++ L G P+ + I+ G PE PE L++ Sbjct: 204 PVDLWACGVILYILL-VGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKM 262 Query: 576 WIYKWEDRPDFLTVEQRMRACYYSLASKV 604 R +T + ++ + S S V Sbjct: 263 LTINPSKR---ITAAEALKHPWISHRSTV 288 >4D2V-A nrPDB Length = 356 Score = 230 bits (587), Expect = 1e-60, Method: Composition-based stats. Identities = 60/269 (22%), Positives = 114/269 (42%), Gaps = 12/269 (4%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G G F V+ + + + VAIK++ + T +D + E + + L + +I +L Sbjct: 37 IGTGGFAKVKLACHILTGEM--VAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYH 94 Query: 404 VCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 V + + +V+E GG L +++ + + + Q+ + Y+ + + HRDL Sbjct: 95 VLETANKIFMVLEYCPGGELFDYIISQD-RLSEEETRVVFRQIVSAVAYVHSQGYAHRDL 153 Query: 463 AARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKF-SSRSD 521 N+L H K+ DFGL + Y+ A L + APE I + + S +D Sbjct: 154 KPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQ--ACCGALAYAAPELIQGKSYLGSEAD 211 Query: 522 VWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWE 581 VWS G+ ++ + G P+ ++A I +GK + P P L+ + Sbjct: 212 VWSMGILLYVLMC-GFLPFDDDTAAALVAKIMRGKY-DVPKWLSPSSILLLQQMLQVDPK 269 Query: 582 DRPDFLTVEQ---RMRACYYSLASKVEGP 607 R + M+ Y + + + P Sbjct: 270 KRISMKNLLNHPWIMQDYNYPVEWQSKNP 298 >3HDN-A nrPDB Length = 373 Score = 229 bits (584), Expect = 3e-60, Method: Composition-based stats. Identities = 66/312 (21%), Positives = 130/312 (41%), Gaps = 20/312 (6%) Query: 299 ITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYR 358 I+ P +P M + + +P K + + +G G+FG V ++ Sbjct: 2 ISQPQEPELMNANPAPPPAPSQQINLGPSSNPHAKPSDFHFLKV-IGKGSFGKVLLARHK 60 Query: 359 MRKKQIDVAIKVLKQGT--EKADTEEMMREAQIM-HQLDNPYIVRLIGVCQA-EALMLVM 414 +++ A+KVL++ +K + + +M E ++ + +P++V L Q + L V+ Sbjct: 61 A--EEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVL 118 Query: 415 EMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHY 474 + GG L L +R +++ + YL N V+RDL N+LL ++ + Sbjct: 119 DYINGGELFYHLQRER-CFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGH 177 Query: 475 AKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALS 534 ++DFGL K + + + S ++ APE ++ + + D W G ++E L Sbjct: 178 IVLTDFGLCKE---NIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML- 233 Query: 535 YGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRP----DFLTVE 590 YG P+ E+ I K ++ P L+ R DF+ ++ Sbjct: 234 YGLPPFYSRNTAEMYDNILN-KPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIK 292 Query: 591 QRMRACYYSLAS 602 ++SL + Sbjct: 293 S---HVFFSLIN 301 >5F9E-A nrPDB Length = 353 Score = 229 bits (584), Expect = 3e-60, Method: Composition-based stats. Identities = 74/300 (24%), Positives = 126/300 (42%), Gaps = 29/300 (9%) Query: 323 EELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADT 380 +E ++ LK ++ + + LG G+FG V ++ K AIK LK+ D Sbjct: 7 KERPSLQIKLKIEDFELHKM-LGKGSFGKVFLAEFK--KTNQFFAIKALKKDVVLMDDDV 63 Query: 381 EEMMREAQIMHQL-DNPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNV 438 E M E +++ ++P++ + Q E L VME GG L + + + +S Sbjct: 64 ECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLM-YHIQSCHKFDLSRA 122 Query: 439 AELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSA 498 ++ +G+++L K V+RDL N+LL + KI+DFG+ K D+ + Sbjct: 123 TFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDA---KTNE 179 Query: 499 GKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM 558 + APE + +K++ D WS+GV ++E L GQ P+ E+ I Sbjct: 180 FCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEML-IGQSPFHGQDEEELFHSIRMDN-P 237 Query: 559 ECPPECPPELYALMSDCWIYKWEDR----------PDFLTVEQRMRACYYSLASKVEGPP 608 P E L+ ++ + E R P F + + L K PP Sbjct: 238 FYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREIN------WEELERKEIDPP 291 >5FET-A nrPDB Length = 847 Score = 229 bits (583), Expect = 4e-60, Method: Composition-based stats. Identities = 75/334 (22%), Positives = 135/334 (40%), Gaps = 38/334 (11%) Query: 274 PSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMP------------MDTSVYESPYSD 321 +T +R+ TL + Y E A + D+PR +D SV+ Sbjct: 456 EVEVTKNGKRLRTLGKNDYFGERALLY--DEPRTASIISKATSVECWFVDKSVFLQIIQG 513 Query: 322 P------EELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT 375 P E +K + ++ L I +G G FG+V+ ++ QI A+K + + + Sbjct: 514 PMLTHLEERIKMQDTKVEMHELETERI-IGRGTFGTVKLVHHKPT--QIRYALKCVSKRS 570 Query: 376 --EKADTEEMMREAQIMHQLDNPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREE 432 + E +I + D+P+I+RL+ + + E+ GG L+ + K Sbjct: 571 IISLNQQNNIKLEREITAENDHPFIIRLVRTFKDSNCFYFLTELVTGGELYDAIR-KLGL 629 Query: 433 IPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSY 492 + L + + ++YL E+N V+RDL N+LL + Y K+ DFG +K + Sbjct: 630 LSKPQAQFYLGSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQG---- 685 Query: 493 YTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP--EVMA 550 + APE I + + D+W+ GV ++E + G P+ + E+ Sbjct: 686 --RAYTLVGTPHYMAPEVILGKGYGCTVDIWALGVCLYEFIC-GPLPFGNDQEDQLEIFR 742 Query: 551 FIEQGKRMECPPECPP-ELYALMSDCWIYKWEDR 583 I G ++ P + LM + R Sbjct: 743 DILTG-QLTFPDYVSDQDSINLMKRLLCRLPQGR 775 >3Q53-A nrPDB Length = 306 Score = 228 bits (582), Expect = 5e-60, Method: Composition-based stats. Identities = 54/252 (21%), Positives = 100/252 (39%), Gaps = 12/252 (4%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ++G G G+V + ++ VAI+ + + E ++ E +M + NP IV + Sbjct: 28 KIGQGASGTVYTAMDVATGQE--VAIRQMNLQQQPKK-ELIINEILVMRENKNPNIVNYL 84 Query: 403 G-VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 + L +VME GG L + + +A + + +++L +HRD Sbjct: 85 DSYLVGDELWVVMEYLAGGSLTDVVTET--CMDEGQIAAVCRECLQALEFLHSNQVIHRD 142 Query: 462 LAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSD 521 + + N+LL K++DFG + + + RS W APE + + + + D Sbjct: 143 IKSDNILLGMDGSVKLTDFGFCAQITPE---QSKRSTMVGTPYWMAPEVVTRKAYGPKVD 199 Query: 522 VWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMEC--PPECPPELYALMSDCWIYK 579 +WS G+ E + G+ PY + I E P + ++ C Sbjct: 200 IWSLGIMAIEMI-EGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMD 258 Query: 580 WEDRPDFLTVEQ 591 E R + Q Sbjct: 259 VEKRGSAKELIQ 270 >4LG4-A nrPDB Length = 299 Score = 228 bits (582), Expect = 5e-60, Method: Composition-based stats. Identities = 65/252 (25%), Positives = 117/252 (46%), Gaps = 12/252 (4%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 +LG G++GSV + +++ + VAIK + ++D +E+++E IM Q D+PY+V+ Sbjct: 18 KLGEGSYGSVFKAIHKESGQ--VVAIKQVPV---ESDLQEIIKEISIMQQCDSPYVVKYY 72 Query: 403 G-VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 G + L +VME G G + + + + + +A +L G++YL +HR+ Sbjct: 73 GSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRN 132 Query: 462 LAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSD 521 + A N+LL +AK++DFG++ L R+ W APE I ++ +D Sbjct: 133 IKAGNILLNTEGHAKLADFGVAGQLTDT---MAKRNTVIGTPFWMAPEVIQEIGYNCVAD 189 Query: 522 VWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMEC--PPECPPELYALMSDCWIYK 579 +WS G+T E + G+ PY + + I P + + C + Sbjct: 190 IWSLGITSIEM-AEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKN 248 Query: 580 WEDRPDFLTVEQ 591 E R + Q Sbjct: 249 PEQRATATQLLQ 260 >5KCV-A nrPDB Length = 460 Score = 228 bits (581), Expect = 7e-60, Method: Composition-based stats. Identities = 63/263 (23%), Positives = 105/263 (39%), Gaps = 13/263 (4%) Query: 325 LKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG--TEKADTEE 382 L K + + + LG G FG V + + A+K+LK+ K + Sbjct: 152 LAKPKHRVTMNEFEYLKL-LGKGTFGKVILVKEKATGR--YYAMKILKKEVIVAKDEVAH 208 Query: 383 MMREAQIMHQLDNPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAEL 441 + E +++ +P++ L Q + L VME A GG L L +R Sbjct: 209 TLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRER-VFSEDRARFY 267 Query: 442 LHQVSMGMKYLEE-KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK 500 ++ + YL KN V+RDL N++L + KI+DFGL K D + Sbjct: 268 GAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTF---C 324 Query: 501 WPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMEC 560 ++ APE + + D W GV M+E + G+ P+ ++ I + + Sbjct: 325 GTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILM-EEIRF 382 Query: 561 PPECPPELYALMSDCWIYKWEDR 583 P PE +L+S + R Sbjct: 383 PRTLGPEAKSLLSGLLKKDPKQR 405 >4YNZ-A nrPDB Length = 342 Score = 227 bits (580), Expect = 7e-60, Method: Composition-based stats. Identities = 64/271 (23%), Positives = 126/271 (46%), Gaps = 16/271 (5%) Query: 341 DIELGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTEEMMREAQIMHQLDNPYIV 399 + LG G G V+ G++ + ++ VAIK++ ++ ++ ++ RE I+ +++P+++ Sbjct: 15 EKTLGKGQTGLVKLGIHCVTCQK--VAIKIVNREKLSESVLMKVEREIAILKLIEHPHVL 72 Query: 400 RLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 +L V + + L LV+E GG L +LV K + + Q+ + + + Sbjct: 73 KLHDVYENKKYLYLVLEHVSGGELFDYLVKK-GRLTPKEARKFFRQIISALDFCHSHSIC 131 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFS- 517 HRDL N+LL R+ +I+DFG++ D T+ + + PE I K+ Sbjct: 132 HRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGS----PHYACPEVIRGEKYDG 187 Query: 518 SRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWI 577 ++DVWS GV ++ L G P+ +++ +++G P PP+ +L+ Sbjct: 188 RKADVWSCGVILFALL-VGALPFDDDNLRQLLEKVKRG-VFHMPHFIPPDCQSLLRGMIE 245 Query: 578 YKWEDRPDFLTVEQRMRACYYSLASKVEGPP 608 R +++ +Y + K E P Sbjct: 246 VDAARRLTLEHIQK---HIWY-IGGKNEPEP 272 >3SOA-A nrPDB Length = 444 Score = 227 bits (579), Expect = 1e-59, Method: Composition-based stats. Identities = 63/269 (23%), Positives = 116/269 (43%), Gaps = 16/269 (5%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ELG G F VR+ V + ++ I K+ + + D +++ REA+I L +P IVRL Sbjct: 18 ELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSAR-DHQKLEREARICRLLKHPNIVRLH 76 Query: 403 GVCQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 E L+ ++ GG L + +V RE ++ + + Q+ + + + VHR+ Sbjct: 77 DSISEEGHHYLIFDLVTGGELFEDIVA-REYYSEADASHCIQQILEAVLHCHQMGVVHRN 135 Query: 462 LAARNVLLVNRHY---AKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 L N+LL ++ K++DFGL+ + + + + +PE + + Sbjct: 136 LKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAW---FGFAGTPGYLSPEVLRKDPYGK 192 Query: 519 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPE---CPPELYALMSDC 575 D+W+ GV ++ L G P+ + I+ G PE PE L++ Sbjct: 193 PVDLWACGVILYILL-VGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKM 251 Query: 576 WIYKWEDRPDFLTVEQRMRACYYSLASKV 604 R +T + ++ + S S V Sbjct: 252 LTINPSKR---ITAAEALKHPWISHRSTV 277 >3MV5-A nrPDB Length = 342 Score = 226 bits (577), Expect = 2e-59, Method: Composition-based stats. Identities = 61/244 (25%), Positives = 100/244 (40%), Gaps = 12/244 (4%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG--TEKADTEEMMREAQIMHQLDNPYIVRL 401 LG G FG V + + A+K+LK+ K + + E +++ +P++ L Sbjct: 18 LGKGTFGKVILVKEKATGR--YYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTAL 75 Query: 402 IGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE-KNFVH 459 Q + L VME A GG L L +R ++ + YL KN V+ Sbjct: 76 KYSFQTHDRLCFVMEYANGGELFFHLSRER-VFSEDRARFYGAEIVSALDYLHSEKNVVY 134 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 519 RDL N++L + KI+DFGL K D + ++ APE + + Sbjct: 135 RDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTF---CGTPEYLAPEVLEDNDYGRA 191 Query: 520 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYK 579 D W GV M+E + G+ P+ ++ I + + P PE +L+S Sbjct: 192 VDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILM-EEIRFPRTLGPEAKSLLSGLLKKD 249 Query: 580 WEDR 583 + R Sbjct: 250 PKQR 253 >4L42-A nrPDB Length = 346 Score = 226 bits (577), Expect = 2e-59, Method: Composition-based stats. Identities = 69/272 (25%), Positives = 112/272 (41%), Gaps = 19/272 (6%) Query: 317 SPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGV-YRMRKKQIDVAIKVLKQGT 375 S PE+++ + L R LG G +G V Q A+KVLK+ Sbjct: 7 SVNRGPEKIRPECFELLR--------VLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAM 58 Query: 376 ---EKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKRE 431 DT E I+ ++ +P+IV LI Q L L++E GG L L + Sbjct: 59 IVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQL-EREG 117 Query: 432 EIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDS 491 L ++SM + +L +K ++RDL N++L ++ + K++DFGL K D Sbjct: 118 IFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDG- 176 Query: 492 YYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAF 551 T +++ APE + + D WS G M++ L+ G P+ + + Sbjct: 177 --TVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLT-GAPPFTGENRKKTIDK 233 Query: 552 IEQGKRMECPPECPPELYALMSDCWIYKWEDR 583 I + K + PP E L+ R Sbjct: 234 ILKCK-LNLPPYLTQEARDLLKKLLKRNAASR 264 >6AO5-A nrPDB Length = 362 Score = 226 bits (577), Expect = 2e-59, Method: Composition-based stats. Identities = 65/252 (25%), Positives = 117/252 (46%), Gaps = 12/252 (4%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 +LG G++GSV + +++ + VAIK + ++D +E+++E IM Q D+PY+V+ Sbjct: 17 KLGEGSYGSVFKAIHKESGQ--VVAIKQVPV---ESDLQEIIKEISIMQQCDSPYVVKYY 71 Query: 403 G-VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 G + L +VME G G + + + + + +A +L G++YL +HR+ Sbjct: 72 GSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRN 131 Query: 462 LAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSD 521 + A N+LL +AK++DFG++ L R+ W APE I ++ +D Sbjct: 132 IKAGNILLNTEGHAKLADFGVAGQLTDT---MAKRNTVIGTPFWMAPEVIQEIGYNCVAD 188 Query: 522 VWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMEC--PPECPPELYALMSDCWIYK 579 +WS G+T E + G+ PY + + I P + + C + Sbjct: 189 IWSLGITSIEM-AEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKN 247 Query: 580 WEDRPDFLTVEQ 591 E R + Q Sbjct: 248 PEQRATATQLLQ 259 >4YZB-A nrPDB Length = 491 Score = 226 bits (576), Expect = 2e-59, Method: Composition-based stats. Identities = 63/252 (25%), Positives = 112/252 (44%), Gaps = 14/252 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LG G+FG V ++ ++ V + +Q +K D E +++E +++ +LD+P I++L Sbjct: 38 LGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHPNIMKLYE 97 Query: 404 VCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 + + LV E+ GG L ++ R+ + A ++ QV G+ Y+ + VHRDL Sbjct: 98 FFEDKGYFYLVTEVYTGGELFDEIIS-RKRFSEVDAARIIRQVLSGITYMHKNKIVHRDL 156 Query: 463 AARNVLLVN---RHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 519 N+LL N +I DFGLS + + APE ++ + + Sbjct: 157 KPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDK----IGTAYYIAPEVLHGT-YDEK 211 Query: 520 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKR---MECPPECPPELYALMSDCW 576 DVWS GV ++ LS G P+ +++ +E+GK + + L+ Sbjct: 212 CDVWSTGVILYILLS-GCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIRKML 270 Query: 577 IYKWEDRPDFLT 588 Y R Sbjct: 271 AYVPTMRISARD 282 >2JAM-A nrPDB Length = 304 Score = 226 bits (576), Expect = 2e-59, Method: Composition-based stats. Identities = 61/257 (23%), Positives = 103/257 (40%), Gaps = 18/257 (7%) Query: 334 RDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL 393 R + ++ LG G F V R+ K A+K +K+ D+ + E ++ ++ Sbjct: 8 RKTFIFMEV-LGSGAFSEVFLVKQRLTGK--LFALKCIKKSPAFRDS-SLENEIAVLKKI 63 Query: 394 DNPYIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYL 452 + IV L + + LVM++ GG L ++ +R + + ++ QV +KYL Sbjct: 64 KHENIVTLEDIYESTTHYYLVMQLVSGGELFDRIL-ERGVYTEKDASLVIQQVLSAVKYL 122 Query: 453 EEKNFVHRDLAARNVLL---VNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPE 509 E VHRDL N+L I+DFGLSK S + APE Sbjct: 123 HENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNG-----IMSTACGTPGYVAPE 177 Query: 510 CINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKR-MECP--PECPP 566 + + +S D WS GV + L G P+ + ++ I++G E P + Sbjct: 178 VLAQKPYSKAVDCWSIGVITYILLC-GYPPFYEETESKLFEKIKEGYYEFESPFWDDISE 236 Query: 567 ELYALMSDCWIYKWEDR 583 + +R Sbjct: 237 SAKDFICHLLEKDPNER 253 >4YFF-A nrPDB Length = 311 Score = 225 bits (574), Expect = 4e-59, Method: Composition-based stats. Identities = 76/278 (27%), Positives = 137/278 (49%), Gaps = 19/278 (6%) Query: 336 NLLIADIE----LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQI 389 +L +++IE +G G+FG V +G R + VAIK + T K+D + RE I Sbjct: 38 HLQLSEIEFHEIIGSGSFGKVYKGRCRNK----IVAIKRYRANTYCSKSDVDMFCREVSI 93 Query: 390 MHQLDNPYIVRLIGVCQAEA--LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSM 447 + QL++P +++ +G C + +V + GG L L ++ + + + + V+ Sbjct: 94 LCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAK 153 Query: 448 GMKYLEE--KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKW 505 GM+YL + +HRDL + N+LL +A ++DFG S+ L + D + G L+W Sbjct: 154 GMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGN--LRW 211 Query: 506 YAPECI-NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK-RMECPPE 563 APE +++ ++DV+SY + +WE L+ G+ P+ +K A + R Sbjct: 212 MAPEVFTQCTRYTIKADVFSYALCLWEILT-GEIPFAHLKPAAAAADMAYHHIRPPIGYS 270 Query: 564 CPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLA 601 P + +L+ W E RP+F V ++ C ++ Sbjct: 271 IPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNIE 308 >4RLP-A nrPDB Length = 288 Score = 225 bits (573), Expect = 5e-59, Method: Composition-based stats. Identities = 64/245 (26%), Positives = 103/245 (42%), Gaps = 11/245 (4%) Query: 344 LGCGNFGSVRQGV-YRMRKKQIDVAIKVLKQGT---EKADTEEMMREAQIMHQLDNPYIV 399 LG G +G V Q A+KVLK+ DT E I+ ++ +P+IV Sbjct: 13 LGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIV 72 Query: 400 RLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 LI Q L L++E GG L L + L ++SM + +L +K + Sbjct: 73 DLIYAFQTGGKLYLILEYLSGGELFMQL-EREGIFMEDTACFYLAEISMALGHLHQKGII 131 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 +RDL N++L ++ + K++DFGL K D T +++ APE + + Sbjct: 132 YRDLKPENIMLNHQGHVKLTDFGLCKESIHDG---TVTHTFCGTIEYMAPEILMRSGHNR 188 Query: 519 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIY 578 D WS G M++ L+ G P+ + + I + K + PP E L+ Sbjct: 189 AVDWWSLGALMYDMLT-GAPPFTGENRKKTIDKILKCK-LNLPPYLTQEARDLLKKLLKR 246 Query: 579 KWEDR 583 R Sbjct: 247 NAASR 251 >4PDS-A nrPDB Length = 347 Score = 225 bits (573), Expect = 6e-59, Method: Composition-based stats. Identities = 65/267 (24%), Positives = 111/267 (41%), Gaps = 27/267 (10%) Query: 336 NLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN 395 + I D +G G F +V++ + R K V K++ + + + + RE +++ +L++ Sbjct: 31 DFSIIDEVVGQGAFATVKKAIERTTGKTFSV--KIISKRKVIGNMDGVTRELEVLQKLNH 88 Query: 396 PYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 454 P IVRL G + E+ +VME GG L F+ + E+ Q+ +KY+ Sbjct: 89 PRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAH-GAVGEDAGREISRQILTAIKYIHS 147 Query: 455 KNFVHRDLAARNVLLVNRH--YAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN 512 HRDL N+L+ KI+ FGL+K G T L + APE I Sbjct: 148 MGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFC----GTLAYVAPEVIR 203 Query: 513 FR-------------KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRME 559 + ++SS D+WS G ++ L+ G P+ ++ I +G E Sbjct: 204 GKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILT-GHLPFSGSTQDQLYKQIGRGSYHE 262 Query: 560 CPPE---CPPELYALMSDCWIYKWEDR 583 P + E + +R Sbjct: 263 GPLKDFRISEEARDFIDSLLQVDPNNR 289 >4F0G-A nrPDB Length = 287 Score = 225 bits (573), Expect = 6e-59, Method: Composition-based stats. Identities = 82/292 (28%), Positives = 138/292 (47%), Gaps = 28/292 (9%) Query: 323 EELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTE- 381 E +L DN + + ++G G FG V +G R+ K + VAIK L G + +TE Sbjct: 6 SEFPKSRLPTLADNEIEYEKQIGKGGFGLVHKG--RLVKDKSVVAIKSLILGDSEGETEM 63 Query: 382 -----EMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVS 436 E RE IM L++P IV+L G+ +VME G L+ L+ K I S Sbjct: 64 IEKFQEFQREVFIMSNLNHPNIVKLYGLMHNPPR-MVMEFVPCGDLYHRLLDKAHPIKWS 122 Query: 437 NVAELLHQVSMGMKYLEEKN--FVHRDLAARNVLL---VNRHYA--KISDFGLSKALGAD 489 L+ +++G++Y++ +N VHRDL + N+ L K++DFGLS+ Sbjct: 123 VKLRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHS 182 Query: 490 DSYYTARSAGKWPLKWYAPECI--NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPE 547 S +W APE I ++ ++D +S+ + ++ L+ G+ P+ + + Sbjct: 183 VSGLLGN------FQWMAPETIGAEEESYTEKADTYSFAMILYTILT-GEGPFDEYSYGK 235 Query: 548 V--MAFI-EQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRAC 596 + + I E+G R P +CPP L ++ CW + RP F + + + Sbjct: 236 IKFINMIREEGLRPTIPEDCPPRLRNVIELCWSGDPKKRPHFSYIVKELSEL 287 >4UZD-A nrPDB Length = 287 Score = 224 bits (572), Expect = 7e-59, Method: Composition-based stats. Identities = 75/288 (26%), Positives = 126/288 (43%), Gaps = 20/288 (6%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTE-EMMREAQIMHQ 392 ++ I LG G FG+V R ++ + +A+KVL K EKA E ++ RE +I Sbjct: 8 EDFEIGR-PLGKGKFGNVYLA--REKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSH 64 Query: 393 LDNPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKY 451 L +P I+RL G + L++E A G +++ L K + A + +++ + Y Sbjct: 65 LRHPNILRLYGYFHDATRVYLILEYAPLGTVYREL-QKLSKFDEQRTATYITELANALSY 123 Query: 452 LEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI 511 K +HRD+ N+LL + KI+DFG S + + R+ L + PE I Sbjct: 124 CHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPS-----SRRTTLCGTLDYLPPEMI 178 Query: 512 NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYAL 571 R + D+WS GV +E L G+ P++ E I + + P L Sbjct: 179 EGRMHDEKVDLWSLGVLCYEFL-VGKPPFEANTYQETYKRISRVE-FTFPDFVTEGARDL 236 Query: 572 MSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKAEAACA 619 +S + RP + + + + + S P + Q E+A A Sbjct: 237 ISRLLKHNPSQRP---MLREVLEHPWITANSS---KPSNCQNKESAAA 278 >4APC-A nrPDB Length = 350 Score = 224 bits (571), Expect = 8e-59, Method: Composition-based stats. Identities = 49/272 (18%), Positives = 117/272 (43%), Gaps = 9/272 (3%) Query: 324 ELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QGTEKADTEE 382 +L + L+ + + ++G G+FG + + IK + + EE Sbjct: 12 DLGTENLYFQSMEKYVRLQKIGEGSFGKAIL--VKSTEDGRQYVIKEINISRMSSKEREE 69 Query: 383 MMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREE-IPVSNVAE 440 RE ++ + +P IV+ + L +VM+ GG L K + ++ + + Sbjct: 70 SRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILD 129 Query: 441 LLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK 500 Q+ + +K++ ++ +HRD+ ++N+ L ++ DFG+++ L + A Sbjct: 130 WFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARA---CI 186 Query: 501 WPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMEC 560 + +PE + ++++SD+W+ G ++E + + ++ ++ I G Sbjct: 187 GTPYYLSPEICENKPYNNKSDIWALGCVLYELCTL-KHAFEAGSMKNLVLKIISGSFPPV 245 Query: 561 PPECPPELYALMSDCWIYKWEDRPDFLTVEQR 592 +L +L+S + DRP ++ ++ Sbjct: 246 SLHYSYDLRSLVSQLFKRNPRDRPSVNSILEK 277 >3KN6-A nrPDB Length = 325 Score = 224 bits (571), Expect = 8e-59, Method: Composition-based stats. Identities = 62/275 (22%), Positives = 113/275 (41%), Gaps = 26/275 (9%) Query: 331 FLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIM 390 F + +L + D LG G+F R+ V++ K A+K++ + E +E + Sbjct: 6 FYQHYDLDLKDKPLGEGSFSICRKCVHK--KSNQAFAVKIISKRME----ANTQKEITAL 59 Query: 391 HQLD-NPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMG 448 + +P IV+L V + LVME+ GG L + + K++ + + ++ ++ Sbjct: 60 KLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERI-KKKKHFSETEASYIMRKLVSA 118 Query: 449 MKYLEEKNFVHRDLAARNVLL---VNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKW 505 + ++ + VHRDL N+L + KI DFG ++ D+ + L + Sbjct: 119 VSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKT---PCFTLHY 175 Query: 506 YAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP-------EVMAFIEQGKRM 558 APE +N + D+WS GV ++ LS GQ P++ E+M I++G Sbjct: 176 AAPELLNQNGYDESCDLWSLGVILYTMLS-GQVPFQSHDRSLTCTSAVEIMKKIKKGDFS 234 Query: 559 ECPP---ECPPELYALMSDCWIYKWEDRPDFLTVE 590 E L+ R + Sbjct: 235 FEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLR 269 >3DAK-A nrPDB Length = 290 Score = 224 bits (570), Expect = 1e-58, Method: Composition-based stats. Identities = 69/282 (24%), Positives = 119/282 (42%), Gaps = 24/282 (8%) Query: 330 LFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQI 389 + RD+ + ++ +G G V+ +K++ VAIK + + +E+++E Q Sbjct: 5 WSINRDDYELQEV-IGSGATAVVQAAYCAPKKEK--VAIKRINLEKCQTSMDELLKEIQA 61 Query: 390 MHQLDNPYIVRLI-GVCQAEALMLVMEMAGGGPLHKFLVG-------KREEIPVSNVAEL 441 M Q +P IV + L LVM++ GG + + K + S +A + Sbjct: 62 MSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATI 121 Query: 442 LHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYY--TARSAG 499 L +V G++YL + +HRD+ A N+LL +I+DFG+S L R Sbjct: 122 LREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTF 181 Query: 500 KWPLKWYAPECINF-RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM 558 W APE + R + ++D+WS+G+T E L+ G PY K +V+ Q Sbjct: 182 VGTPCWMAPEVMEQVRGYDFKADIWSFGITAIE-LATGAAPYHKYPPMKVLMLTLQNDPP 240 Query: 559 ECP---------PECPPELYALMSDCWIYKWEDRPDFLTVEQ 591 + ++S C E RP + + Sbjct: 241 SLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLR 282 >3TXO-A nrPDB Length = 353 Score = 224 bits (570), Expect = 1e-58, Method: Composition-based stats. Identities = 57/253 (22%), Positives = 102/253 (40%), Gaps = 13/253 (5%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQIMHQ 392 DN + LG G+FG V + A+KVLK+ + D E M E +I+ Sbjct: 23 DNFEFIRV-LGKGSFGKVMLARVKETGD--LYAVKVLKKDVILQDDDVECTMTEKRILSL 79 Query: 393 L-DNPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMK 450 ++P++ +L Q + L VME GG L + R + ++ + Sbjct: 80 ARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSR-RFDEARARFYAAEIISALM 138 Query: 451 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510 +L +K ++RDL NVLL + + K++DFG+ K + + + APE Sbjct: 139 FLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNG---VTTATFCGTPDYIAPEI 195 Query: 511 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYA 570 + + D W+ GV ++E L G P++ ++ I + + P + Sbjct: 196 LQEMLYGPAVDWWAMGVLLYEMLC-GHAPFEAENEDDLFEAILNDE-VVYPTWLHEDATG 253 Query: 571 LMSDCWIYKWEDR 583 ++ R Sbjct: 254 ILKSFMTKNPTMR 266 >2UV2-A nrPDB Length = 325 Score = 223 bits (569), Expect = 1e-58, Method: Composition-based stats. Identities = 65/304 (21%), Positives = 124/304 (40%), Gaps = 18/304 (5%) Query: 307 PMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDV 366 +D + ++ + L ++ ELG G FG V + + + Sbjct: 8 SSGVDLGTENLYFQSMKQYEHVTRDLNPEDFWEIIGELGDGAFGKVYKAQNKETS--VLA 65 Query: 367 AIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKF 425 A KV+ +E+ + E+ M E I+ D+P IV+L+ E L +++E GG + Sbjct: 66 AAKVIDTKSEE-ELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAV 124 Query: 426 LVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKA 485 ++ + S + + Q + YL + +HRDL A N+L K++DFG+S Sbjct: 125 MLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAK 184 Query: 486 LGADDSYYTARSAGKWPLKWYAPECIN-----FRKFSSRSDVWSYGVTMWEALSYGQKPY 540 + R + W APE + R + ++DVWS G+T+ E + + P+ Sbjct: 185 ---NTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEM-AEIEPPH 240 Query: 541 KKMKGPEVMAFIEQGKR--MECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYY 598 ++ V+ I + + + P + C + R T Q ++ + Sbjct: 241 HELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDAR---WTTSQLLQHPFV 297 Query: 599 SLAS 602 ++ S Sbjct: 298 TVDS 301 >2Y7J-A nrPDB Length = 365 Score = 223 bits (568), Expect = 2e-58, Method: Composition-based stats. Identities = 78/361 (21%), Positives = 133/361 (36%), Gaps = 30/361 (8%) Query: 258 SASNASGAAAPTLPAHPSTLTHPQRR--IDTLNSDGYTPEPARITSPDKPRPMPMDTSVY 315 + N A H L QRR I +L D + P T Sbjct: 13 NKFNKERRRARREIRHLPNLNREQRRAFIRSLRDDPSQSANLLAEAKKLNDAQPKGTENL 72 Query: 316 ESPYSDPEELKDKKLFLKRDNLLIADIE--LGCGNFGSVRQGVYRMRKKQIDVAIK---- 369 PE+ + ++ D + +G G VR+ V+R + V I Sbjct: 73 YFQSMGPED-ELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTA 131 Query: 370 -VLKQGTEKADTEEMMREAQIMHQL-DNPYIVRLIGVCQAEALM-LVMEMAGGGPLHKFL 426 L + E RE I+ Q+ +P+I+ LI ++ + M LV ++ G L +L Sbjct: 132 ERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYL 191 Query: 427 VGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKAL 486 K + ++ + + +L N VHRDL N+LL + ++SDFG S L Sbjct: 192 TEK-VALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHL 250 Query: 487 GADDSYYTARSAGKWPLKWYAPECINFR------KFSSRSDVWSYGVTMWEALSYGQKPY 540 + + APE + + D+W+ GV ++ L+ G P+ Sbjct: 251 EPGEKLRELC----GTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLA-GSPPF 305 Query: 541 KKMKGPEVMAFIEQGKRMECPPE---CPPELYALMSDCWIYKWEDRPDFLTVEQRMRACY 597 + ++ I +G+ PE + L+S E R LT EQ ++ + Sbjct: 306 WHRRQILMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEAR---LTAEQALQHPF 362 Query: 598 Y 598 + Sbjct: 363 F 363 >1KOA-A nrPDB Length = 491 Score = 222 bits (567), Expect = 3e-58, Method: Composition-based stats. Identities = 66/316 (20%), Positives = 120/316 (37%), Gaps = 24/316 (7%) Query: 293 TPEPARITSPDKPRPMPMDTSVYE---SPYSDPEELKDKKLFLKRDNLLIADIELGCGNF 349 E +I D V++ Y P E+K + D+ I + ELG G F Sbjct: 9 VDEQGKIVRGKGTVSSNYDNYVFDIWKQYYPQPVEIKHDHVL---DHYDIHE-ELGTGAF 64 Query: 350 GSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA 409 G V + R A K + ++D E + +E Q M L +P +V L + + Sbjct: 65 GVVHRVTERATGNNF--AAKFVMTP-HESDKETVRKEIQTMSVLRHPTLVNLHDAFEDDN 121 Query: 410 -LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVL 468 ++++ E GG L + + + ++ E + QV G+ ++ E N+VH DL N++ Sbjct: 122 EMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIM 181 Query: 469 LVNR--HYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYG 526 + + K+ DFGL+ L S ++ APE + +D+WS G Sbjct: 182 FTTKRSNELKLIDFGLTAHLDPKQSV----KVTTGTAEFAAPEVAEGKPVGYYTDMWSVG 237 Query: 527 VTMWEALSYGQKPYKKMKGPEVMAFIEQ---GKRMECPPECPPELYALMSDCWIYKWEDR 583 V + LS G P+ E + ++ + + + R Sbjct: 238 VLSYILLS-GLSPFGGENDDETLRNVKSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTR 296 Query: 584 PDFLTVEQRMRACYYS 599 + Q + + + Sbjct: 297 MT---IHQALEHPWLT 309 >6E9W-A nrPDB Length = 443 Score = 222 bits (567), Expect = 3e-58, Method: Composition-based stats. Identities = 70/326 (21%), Positives = 129/326 (39%), Gaps = 22/326 (6%) Query: 285 DTLNSDGYTPEP-ARITSPDKPRP-MPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADI 342 +NSD A + D P + + S Y D K + L +K ++ + + Sbjct: 51 SEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTIN-KIRDLRMKAEDYEVVKV 109 Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQIMHQLDNPYIVR 400 +G G FG V+ ++ +K A+K+L + +++D+ E IM ++P++V+ Sbjct: 110 -IGRGAFGEVQLVRHKSTRK--VYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQ 166 Query: 401 LIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 L Q + L +VME GG L + ++P +V + + + F+H Sbjct: 167 LFYAFQDDRYLYMVMEYMPGGDLVNLM--SNYDVPEKWARFYTAEVVLALDAIHSMGFIH 224 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK---- 515 RD+ N+LL + K++DFG + + + +PE + + Sbjct: 225 RDVKPDNMLLDKSGHLKLADFGTC--MKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGY 282 Query: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKR-MECPP--ECPPELYALM 572 + D WS GV ++E L G P+ + I K + P + E L+ Sbjct: 283 YGRECDWWSVGVFLYEML-VGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLI 341 Query: 573 SDCWIYKWEDRPDFLTVEQRMRACYY 598 E R VE+ R ++ Sbjct: 342 CAFLT-DREVRLGRNGVEEIKRHLFF 366 >4B6L-A nrPDB Length = 281 Score = 222 bits (566), Expect = 3e-58, Method: Composition-based stats. Identities = 56/265 (21%), Positives = 104/265 (39%), Gaps = 14/265 (5%) Query: 338 LIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVL--KQGTEKADTEEMMREAQIMHQLDN 395 + LG G F + + A+KV+ + + E+++ E ++ L + Sbjct: 11 YLKGRLLGKGGFARCYEATD--TETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQH 68 Query: 396 PYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 454 +IVR + + + + +E+ L + R + V L Q+ G+KYL + Sbjct: 69 RHIVRFSHHFEDADNIYIFLELCSRKSL-AHIWKARHTLLEPEVRYYLRQILSGLKYLHQ 127 Query: 455 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR 514 + +HRDL N + K+ DFGL+ L + + + APE + + Sbjct: 128 RGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQ---RKKTICGTPNYVAPEVLLRQ 184 Query: 515 KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSD 574 +DVWS G M+ L G P++ E I+Q P L++ Sbjct: 185 GHGPEADVWSLGCVMYTLLC-GSPPFETADLKETYRCIKQVHY-TLPASLSLPARQLLAA 242 Query: 575 CWIYKWEDRPDFLTVEQRMRACYYS 599 DRP ++Q +R +++ Sbjct: 243 ILRASPRDRPS---IDQILRHDFFT 264 >3TKU-A nrPDB Length = 433 Score = 222 bits (566), Expect = 4e-58, Method: Composition-based stats. Identities = 72/312 (23%), Positives = 131/312 (41%), Gaps = 19/312 (6%) Query: 276 TLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYE-SPYSDPEELKDKKLFLKR 334 L P R L+ + + + + D V E ++ P K++ L R Sbjct: 30 LLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAKPFTQLVKEMQLHR 89 Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQIMHQ 392 ++ I + +G G FG V V +M+ + A+K+L + ++A+T E ++ Sbjct: 90 EDFEIIKV-IGRGAFGEV--AVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVN 146 Query: 393 LDNPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKY 451 D +I L Q E L LVM+ GG L L +++P + ++ + + Sbjct: 147 GDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDS 206 Query: 452 LEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI 511 + + ++VHRD+ NVLL + +++DFG + D + ++ + G + +PE + Sbjct: 207 IHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVG--TPDYISPEIL 264 Query: 512 N-----FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG-KRMECPP--- 562 K+ D WS GV M+E L YG+ P+ E I +R + P Sbjct: 265 QAMEDGMGKYGPECDWWSLGVCMYEML-YGETPFYAESLVETYGKIMNHEERFQFPSHVT 323 Query: 563 ECPPELYALMSD 574 + E L+ Sbjct: 324 DVSEEAKDLIQR 335 >3DB8-A nrPDB Length = 317 Score = 222 bits (565), Expect = 4e-58, Method: Composition-based stats. Identities = 63/286 (22%), Positives = 108/286 (37%), Gaps = 18/286 (6%) Query: 313 SVYESPYSDPEELKDKKL--------FLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQI 364 S S + DP+ K++ +KR + LG G F + K+ Sbjct: 14 SAKPSAHVDPKSAPLKEIPDVLVDPRTMKRY---MRGRFLGKGGFAKCYEITDMDTKEVF 70 Query: 365 DVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEAL-MLVMEMAGGGPLH 423 + + E+M E I LDNP++V G + + +V+E+ L Sbjct: 71 AGKVVPKSMLLKPHQKEKMSTEIAIHKSLDNPHVVGFHGFFEDDDFVYVVLEICRRRSLL 130 Query: 424 KFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLS 483 + L +R+ + + Q G++YL +HRDL N+ L + KI DFGL+ Sbjct: 131 E-LHKRRKAVTEPEARYFMRQTIQGVQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLA 189 Query: 484 KALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKM 543 + D + + APE + + S D+WS G ++ L G+ P++ Sbjct: 190 TKIEFDGE---RKKDLCGTPNYIAPEVLCKKGHSFEVDIWSLGCILYTLL-VGKPPFETS 245 Query: 544 KGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTV 589 E I++ + P P AL+ RP + Sbjct: 246 CLKETYIRIKKNEY-SVPRHINPVASALIRRMLHADPTLRPSVAEL 290 >4JXF-A nrPDB Length = 266 Score = 221 bits (564), Expect = 5e-58, Method: Composition-based stats. Identities = 62/270 (22%), Positives = 108/270 (40%), Gaps = 14/270 (5%) Query: 333 KRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQIM 390 K ++ + ++ LG G+F V + ++VAIK++ + + + + E +I Sbjct: 5 KIEDFKVGNL-LGKGSFAGVYRAESIHTG--LEVAIKMIDKKAMYKAGMVQRVQNEVKIH 61 Query: 391 HQLDNPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGM 449 QL +P I+ L + + LV+EM G ++++L + + + +HQ+ GM Sbjct: 62 CQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGM 121 Query: 450 KYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPE 509 YL +HRDL N+LL KI+DFGL+ L + + +PE Sbjct: 122 LYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKH---YTLCGTPNYISPE 178 Query: 510 CINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELY 569 SDVWS G + L G+ P+ + + E P E Sbjct: 179 IATRSAHGLESDVWSLGCMFYTLL-IGRPPFDTDTVKNTLNKVVLADY-EMPSFLSIEAK 236 Query: 570 ALMSDCWIYKWEDRPDFLTVEQRMRACYYS 599 L+ DR +V + + S Sbjct: 237 DLIHQLLRRNPADRLSLSSV---LDHPFMS 263 >2W4O-A nrPDB Length = 349 Score = 221 bits (564), Expect = 6e-58, Method: Composition-based stats. Identities = 63/265 (23%), Positives = 108/265 (40%), Gaps = 20/265 (7%) Query: 336 NLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN 395 + + ELG G V + + + Q A+KVLK+ +K E ++ +L + Sbjct: 53 DFFEVESELGRGATSIVYRC--KQKGTQKPYALKVLKKTVDKKIVR---TEIGVLLRLSH 107 Query: 396 PYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 454 P I++L + + + LV+E+ GG L +V K + A+ + Q+ + YL E Sbjct: 108 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEK-GYYSERDAADAVKQILEAVAYLHE 166 Query: 455 KNFVHRDLAARNVLLVN---RHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI 511 VHRDL N+L KI+DFGLSK + + + APE + Sbjct: 167 NGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIV----EHQVLMKTVCGTPGYCAPEIL 222 Query: 512 NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVM-AFIEQGKRMECPP---ECPPE 567 + D+WS G+ + L G +P+ +G + M I + P E Sbjct: 223 RGCAYGPEVDMWSVGIITYILLC-GFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLN 281 Query: 568 LYALMSDCWIYKWEDR-PDFLTVEQ 591 L+ + + R F ++ Sbjct: 282 AKDLVRKLIVLDPKKRLTTFQALQH 306 >4I6B-A nrPDB Length = 308 Score = 221 bits (564), Expect = 7e-58, Method: Composition-based stats. Identities = 53/252 (21%), Positives = 99/252 (39%), Gaps = 7/252 (2%) Query: 341 DIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVR 400 LG G F + K I + ++ E++ +E ++ L + ++V+ Sbjct: 33 GKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHHKHVVQ 92 Query: 401 LIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 + E + +++E ++ R+ + V L Q+ G+KYL E+ +H Sbjct: 93 FYHYFEDKENIYILLEYCSRRS-MAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILH 151 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 519 RDL N + K+ DFGL+ L + R + +PE +N + + Sbjct: 152 RDLKLGNFFINESMELKVGDFGLAARLEPLEH---RRRTICGTPNYLSPEVLNKQGHGAE 208 Query: 520 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYK 579 SD+W+ G M+ L G+ P++ E I + R P L++ Sbjct: 209 SDIWALGCVMYTML-LGRPPFETTNLKETYRSIREA-RYTMPSSLLAPAKHLIASMLSKN 266 Query: 580 WEDRPDFLTVEQ 591 EDRP + + Sbjct: 267 PEDRPSLDDIIR 278 >4TPT-A nrPDB Length = 303 Score = 221 bits (563), Expect = 7e-58, Method: Composition-based stats. Identities = 72/284 (25%), Positives = 116/284 (40%), Gaps = 35/284 (12%) Query: 338 LIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPY 397 LI LG G FG + ++ K + +K L + E+ + + E ++M LD+P Sbjct: 2 LIHGEVLGKGFFGQAIKVTHKATGKVMV--MKELIRCDEETQ-KTFLTEVKVMRSLDHPN 58 Query: 398 IVRLIGV-CQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 +++ IGV + + L L+ E GG L FL P ++ GM YL Sbjct: 59 VLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDP-FPWQQKVRFAKGIASGMAYLHSMC 117 Query: 457 FVHRDLAARNVLLVNRHYAKISDFGLSKALGAD-----------------DSYYTARSAG 499 +HRDL + N L+ ++DFGLS+ + + + R Sbjct: 118 IIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTV 177 Query: 500 KWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQK-------PYKKMKGPEVMAFI 552 W APE +N + + D++S+G+ + E + GQ P G V F Sbjct: 178 VGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII--GQVYADPDCLPRTLDFGLNVKLFW 235 Query: 553 EQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRAC 596 E+ P +CPP + L + C + E RP F +E A Sbjct: 236 EK----FVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEAL 275 >2YCR-A nrPDB Length = 323 Score = 220 bits (561), Expect = 1e-57, Method: Composition-based stats. Identities = 71/286 (24%), Positives = 118/286 (41%), Gaps = 29/286 (10%) Query: 334 RDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT-------EKADTEEMMRE 386 RD +++ LG G G V+ R K+ VAIK++ + E + E Sbjct: 9 RDEYIMSKT-LGSGACGEVKLAFERKTCKK--VAIKIISKRKFAIGSAREADPALNVETE 65 Query: 387 AQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVS 446 +I+ +L++P I+++ AE +V+E+ GG L +VG + + + +Q+ Sbjct: 66 IEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNK-RLKEATCKLYFYQML 124 Query: 447 MGMKYLEEKNFVHRDLAARNVLLV---NRHYAKISDFGLSKALGADDSYYTARSAGKWPL 503 + ++YL E +HRDL NVLL KI+DFG SK LG T Sbjct: 125 LAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLC----GTP 180 Query: 504 KWYAPECI---NFRKFSSRSDVWSYGVTMWEALSYGQKPY-KKMKGPEVMAFIEQGKRME 559 + APE + ++ D WS GV ++ LS G P+ + + I GK Sbjct: 181 TYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEHRTQVSLKDQITSGKYNF 239 Query: 560 CPP---ECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLAS 602 P E + L+ + + R E+ +R + Sbjct: 240 IPEVWAEVSEKALDLVKKLLVVDPKARFT---TEEALRHPWLQDED 282 >5DBX-A nrPDB Length = 328 Score = 220 bits (560), Expect = 2e-57, Method: Composition-based stats. Identities = 68/282 (24%), Positives = 117/282 (41%), Gaps = 24/282 (8%) Query: 330 LFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQI 389 + RD + ++ +G G V+ + + R+++ VAIK + + +E+++E Q Sbjct: 6 WPICRDAYELQEV-IGSGATAVVQAALCKPRQER--VAIKRINLEKCQTSMDELLKEIQA 62 Query: 390 MHQLDNPYIVRLI-GVCQAEALMLVMEMAGGGPLHKFLV-------GKREEIPVSNVAEL 441 M Q +P +V + L LVM++ GG + + K + + +A + Sbjct: 63 MSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATI 122 Query: 442 LHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYY--TARSAG 499 L +V G+ YL +HRDL A N+LL +I+DFG+S L R Sbjct: 123 LKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDF 182 Query: 500 KWPLKWYAPECINF-RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM 558 W APE + R + ++D+WS+G+T E L+ G PY K +V+ Q Sbjct: 183 VGTPCWMAPEVMEQVRGYDFKADMWSFGITAIE-LATGAAPYHKYPPMKVLMLTLQNDPP 241 Query: 559 ECP---------PECPPELYALMSDCWIYKWEDRPDFLTVEQ 591 + L+S C RP + + Sbjct: 242 TLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLK 283 >2XNP-A nrPDB Length = 279 Score = 219 bits (559), Expect = 2e-57, Method: Composition-based stats. Identities = 60/259 (23%), Positives = 111/259 (42%), Gaps = 16/259 (6%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G G++G Q + R +I V ++ +A+ + ++ E ++ +L +P IVR Sbjct: 14 IGTGSYGR-CQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYD 72 Query: 404 VC---QAEALMLVMEMAGGGPLHKFLVG---KREEIPVSNVAELLHQVSMGMKYLEE--- 454 L +VME GG L + +R+ + V ++ Q+++ +K Sbjct: 73 RIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSD 132 Query: 455 --KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN 512 +HRDL NV L + K+ DFGL++ L D S+ + +PE +N Sbjct: 133 GGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVG---TPYYMSPEQMN 189 Query: 513 FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALM 572 ++ +SD+WS G ++E + P+ E+ I +GK P EL ++ Sbjct: 190 RMSYNEKSDIWSLGCLLYELCAL-MPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEII 248 Query: 573 SDCWIYKWEDRPDFLTVEQ 591 + K RP + + Sbjct: 249 TRMLNLKDYHRPSVEEILE 267 >6CMJ-A nrPDB Length = 321 Score = 219 bits (557), Expect = 4e-57, Method: Composition-based stats. Identities = 63/277 (22%), Positives = 124/277 (44%), Gaps = 28/277 (10%) Query: 332 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT----------EKADTE 381 ++ D + D E+G G++G V+ A+KVL + + E Sbjct: 31 VQLDQYTLKD-EIGKGSYGVVKLAYN--ENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIE 87 Query: 382 EMMREAQIMHQLDNPYIVRLIGVCQA---EALMLVMEMAGGGPLHKFLVGKREEIPVSNV 438 ++ +E I+ +LD+P +V+L+ V + L +V E+ GP+ + V + + Sbjct: 88 QVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME--VPTLKPLSEDQA 145 Query: 439 AELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSA 498 + G++YL + +HRD+ N+L+ + KI+DFG+S D+ + Sbjct: 146 RFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVG 205 Query: 499 GKWPLKWYAPECINFRK--FSSRS-DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG 555 + APE ++ + FS ++ DVW+ GVT++ +GQ P+ + + + I+ Sbjct: 206 ---TPAFMAPESLSETRKIFSGKALDVWAMGVTLY-CFVFGQCPFMDERIMCLHSKIKSQ 261 Query: 556 KRMECP--PECPPELYALMSDCWIYKWEDRPDFLTVE 590 +E P P+ +L L++ E R ++ Sbjct: 262 A-LEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK 297 >2I0E-A nrPDB Length = 353 Score = 218 bits (556), Expect = 5e-57, Method: Composition-based stats. Identities = 62/258 (24%), Positives = 112/258 (43%), Gaps = 16/258 (6%) Query: 334 RDNLLIAD----IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG--TEKADTEEMMREA 387 RD + + D + LG G+FG V + + A+K+LK+ + D E M E Sbjct: 14 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDE--LYAVKILKKDVVIQDDDVECTMVEK 71 Query: 388 QIMHQLDNP-YIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQV 445 +++ P ++ +L Q + L VME GG L + + + + ++ Sbjct: 72 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLM-YHIQQVGRFKEPHAVFYAAEI 130 Query: 446 SMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKW 505 ++G+ +L+ K ++RDL NV+L + + KI+DFG+ K D + Sbjct: 131 AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG---VTTKTFCGTPDY 187 Query: 506 YAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP 565 APE I ++ + D W++GV ++E L+ GQ P++ E+ I + + P Sbjct: 188 IAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME-HNVAYPKSMS 245 Query: 566 PELYALMSDCWIYKWEDR 583 E A+ R Sbjct: 246 KEAVAICKGLMTKHPGKR 263 >2F57-A nrPDB Length = 317 Score = 218 bits (556), Expect = 5e-57, Method: Composition-based stats. Identities = 56/264 (21%), Positives = 103/264 (39%), Gaps = 15/264 (5%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 I++G G+ G V + KQ+ V L++ + E + E IM + +V + Sbjct: 51 IKIGEGSTGIVCIATEKHTGKQVAVKKMDLRK---QQRRELLFNEVVIMRDYHHDNVVDM 107 Query: 402 IG-VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 + L +VME GG L + R + +A + V + YL + +HR Sbjct: 108 YSSYLVGDELWVVMEFLEGGALTDIVTHTR--MNEEQIATVCLSVLRALSYLHNQGVIHR 165 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRS 520 D+ + ++LL + K+SDFG + + + W APE I+ + + Sbjct: 166 DIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVG---TPYWMAPEVISRLPYGTEV 222 Query: 521 DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPP--ECPPELYALMSDCWIY 578 D+WS G+ + E + G+ PY + M I + L + + Sbjct: 223 DIWSLGIMVIEMI-DGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVR 281 Query: 579 KWEDRPDFLTVEQRMRACYYSLAS 602 + R T ++ + + LA Sbjct: 282 EPSQR---ATAQELLGHPFLKLAG 302 >2BPM-A nrPDB Length = 309 Score = 218 bits (555), Expect = 6e-57, Method: Composition-based stats. Identities = 62/273 (22%), Positives = 109/273 (39%), Gaps = 39/273 (14%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEM-MREAQIMHQLDNPYIVRL 401 ++G G +G V + ++ + VA+K ++ TE +RE ++ +L++P IV+L Sbjct: 14 KIGEGTYGVVYKARNKLTGE--VVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKL 71 Query: 402 IGVCQAEA-LMLVMEMAGGGPLHKFLVGKREE-IPVSNVAELLHQVSMGMKYLEEKNFVH 459 + V E L LV E L KF+ IP+ + L Q+ G+ + +H Sbjct: 72 LDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLH 130 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK-FSS 518 RDL +N+L+ K++DFGL++A G YT W + APE + K +S+ Sbjct: 131 RDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLW---YRAPEILLGCKYYST 187 Query: 519 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ-----------------GKRMECP 561 D+WS G E ++ + + + I + + P Sbjct: 188 AVDIWSLGCIFAEMVTRRAL-FPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFP 246 Query: 562 PECPPEL-----------YALMSDCWIYKWEDR 583 + +L+S Y R Sbjct: 247 KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKR 279 >4BBM-A nrPDB Length = 331 Score = 218 bits (555), Expect = 6e-57, Method: Composition-based stats. Identities = 60/302 (19%), Positives = 111/302 (36%), Gaps = 43/302 (14%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEM-MREAQIMHQLDNPYIVRLI 402 +G G++G V + + + VAIK + + +++ MRE +++ QL + +V L+ Sbjct: 33 VGEGSYGMVMKCRNKDTGR--IVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLL 90 Query: 403 GVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 VC+ + LV E L + + V + L Q+ G+ + N +HRD Sbjct: 91 EVCKKKKRWYLVFEFVDHTILDDLELFPNG-LDYQVVQKYLFQIINGIGFCHSHNIIHRD 149 Query: 462 LAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR-KFSSRS 520 + N+L+ K+ DFG ++ L A Y A +W + APE + K+ Sbjct: 150 IKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRW---YRAPELLVGDVKYGKAV 206 Query: 521 DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ--------------------GKRMEC 560 DVW+ G + E G+ + + + I G R+ Sbjct: 207 DVWAIGCLVTEMFM-GEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPE 265 Query: 561 P----------PECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGS 610 P+ + L C + RP + + ++ + E Sbjct: 266 IKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRP---FCAELLHHDFFQMDGFAERFSQE 322 Query: 611 TQ 612 Q Sbjct: 323 LQ 324 >3F3Z-A nrPDB Length = 277 Score = 218 bits (555), Expect = 6e-57, Method: Composition-based stats. Identities = 68/285 (23%), Positives = 113/285 (39%), Gaps = 24/285 (8%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 + + +G G++G V+ V + + A K+ K E D + +E +IM LD Sbjct: 8 NQYYTLENTIGRGSWGEVKIAVQKGT-RIRRAAKKIPKYFVE--DVDRFKQEIEIMKSLD 64 Query: 395 NPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 +P I+RL + + LVME+ GG L + +V KR S+ A ++ V + Y Sbjct: 65 HPNIIRLYETFEDNTDIYLVMELCTGGELFERVVHKR-VFRESDAARIMKDVLSAVAYCH 123 Query: 454 EKNFVHRDLAARNVLL---VNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510 + N HRDL N L K+ DFGL+ T + +P+ Sbjct: 124 KLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTK----VGTPYYVSPQV 179 Query: 511 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPP----ECPP 566 + + D WS GV M+ L G P+ EVM I +G P P Sbjct: 180 LEG-LYGPECDEWSAGVMMYVLLC-GYPPFSAPTDSEVMLKIREGT-FTFPEKDWLNVSP 236 Query: 567 ELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGST 611 + +L+ + R +T Q + ++ ++ P + Sbjct: 237 QAESLIRRLLTKSPKQR---ITSLQALEHEWF--EKQLSSSPRNL 276 >5X3F-B nrPDB Length = 393 Score = 218 bits (555), Expect = 6e-57, Method: Composition-based stats. Identities = 51/241 (21%), Positives = 102/241 (42%), Gaps = 10/241 (4%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LG G+FG V ++ + I ++ + E + E +I+ ++ P++V+L Sbjct: 92 LGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEF 151 Query: 404 VCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 + L +VME GG + L + + Q+ + +YL + ++RDL Sbjct: 152 SFKDNSNLYMVMEYVAGGEMFSHLR-RIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDL 210 Query: 463 AARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDV 522 N+L+ + Y +++DFG +K + ++ APE I + ++ D Sbjct: 211 KPENLLIDQQGYIQVTDFGFAKRVKG------RTWTLCGTPEYLAPEIILSKGYNKAVDW 264 Query: 523 WSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWED 582 W+ GV ++E + G P+ + ++ I GK + P +L L+ + Sbjct: 265 WALGVLIYEM-AAGYPPFFADQPIQIYEKIVSGK-VRFPSHFSSDLKDLLRNLLQVDLTK 322 Query: 583 R 583 R Sbjct: 323 R 323 >3D2K-A nrPDB Length = 272 Score = 218 bits (555), Expect = 6e-57, Method: Composition-based stats. Identities = 70/260 (26%), Positives = 112/260 (43%), Gaps = 14/260 (5%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTE-EMMREAQIMHQ 392 ++ I LG G FG+V R R+ + +A+KVL K EKA E ++ RE +I Sbjct: 12 EDFDIGR-PLGKGKFGNVYLA--RERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSH 68 Query: 393 LDNPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKY 451 L +P I+RL G + L++E A G +++ L K A + +++ + Y Sbjct: 69 LRHPNILRLYGYFHDATRVYLILEYAPLGTVYREL-QKLSRFDEQRTATYITELANALSY 127 Query: 452 LEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI 511 K +HRD+ N+LL + KI+DFG S + + R+ L + PE I Sbjct: 128 CHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPS-----SRRTTLCGTLDYLPPEMI 182 Query: 512 NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYAL 571 R + D+WS GV +E L G P++ E I + + P L Sbjct: 183 EGRMHDEKVDLWSLGVLCYEFL-VGMPPFEAHTYQETYRRISRVE-FTFPDFVTEGARDL 240 Query: 572 MSDCWIYKWEDRPDFLTVEQ 591 +S + R V + Sbjct: 241 ISRLLKHNASQRLTLAEVLE 260 >3PFQ-A nrPDB Length = 674 Score = 218 bits (555), Expect = 7e-57, Method: Composition-based stats. Identities = 62/258 (24%), Positives = 112/258 (43%), Gaps = 16/258 (6%) Query: 334 RDNLLIAD----IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG--TEKADTEEMMREA 387 RD + + D + LG G+FG V + + A+K+LK+ + D E M E Sbjct: 335 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDE--LYAVKILKKDVVIQDDDVECTMVEK 392 Query: 388 QIMHQLDNP-YIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQV 445 +++ P ++ +L Q + L VME GG L + + + + ++ Sbjct: 393 RVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLM-YHIQQVGRFKEPHAVFYAAEI 451 Query: 446 SMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKW 505 ++G+ +L+ K ++RDL NV+L + + KI+DFG+ K D + Sbjct: 452 AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDG---VTTKTFCGTPDY 508 Query: 506 YAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP 565 APE I ++ + D W++GV ++E L+ GQ P++ E+ I + + P Sbjct: 509 IAPEIIAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME-HNVAYPKSMS 566 Query: 566 PELYALMSDCWIYKWEDR 583 E A+ R Sbjct: 567 KEAVAICKGLMTKHPGKR 584 >5JZN-A nrPDB Length = 280 Score = 217 bits (554), Expect = 8e-57, Method: Composition-based stats. Identities = 63/264 (23%), Positives = 111/264 (42%), Gaps = 23/264 (8%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G GNF V++ V R ++ A+K++K+ + + E I+ ++ +P IV LI Sbjct: 27 IGDGNFAVVKECVERSTARE--YALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIE 84 Query: 404 VCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 L LVME+ GG L + + + + +L+ ++ +KYL N VHRD+ Sbjct: 85 EMDVPTELYLVMELVKGGDLFDAITS-TNKYTERDASGMLYNLASAIKYLHSLNIVHRDI 143 Query: 463 AARNVLL----VNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 N+L+ K+ DFGL+ + D YT + APE I + Sbjct: 144 KPENLLVYEHQDGSKSLKLGDFGLATIV--DGPLYTVC----GTPTYVAPEIIAETGYGL 197 Query: 519 RSDVWSYGVTMWEALSYGQKPYKKMKGPE--VMAFIEQGKRMECPP---ECPPELYALMS 573 + D+W+ GV + L G P++ + + I G+ P L++ Sbjct: 198 KVDIWAAGVITYILLC-GFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELIT 256 Query: 574 DCWIYKWEDRPDFLTVEQRMRACY 597 + + R F V Q + + Sbjct: 257 MMLLVDVDQR--FSAV-QVLEHPW 277 >3I6U-A nrPDB Length = 419 Score = 217 bits (554), Expect = 9e-57, Method: Composition-based stats. Identities = 70/286 (24%), Positives = 118/286 (41%), Gaps = 29/286 (10%) Query: 334 RDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT-------EKADTEEMMRE 386 RD +++ LG G G V+ R K+ VAI+++ + E + E Sbjct: 134 RDEYIMSKT-LGSGACGEVKLAFERKTCKK--VAIRIISKRKFAIGSAREADPALNVETE 190 Query: 387 AQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVS 446 +I+ +L++P I+++ AE +V+E+ GG L +VG + + + +Q+ Sbjct: 191 IEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNK-RLKEATCKLYFYQML 249 Query: 447 MGMKYLEEKNFVHRDLAARNVLLV---NRHYAKISDFGLSKALGADDSYYTARSAGKWPL 503 + ++YL E +HRDL NVLL KI+DFG SK LG T Sbjct: 250 LAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLC----GTP 305 Query: 504 KWYAPECI---NFRKFSSRSDVWSYGVTMWEALSYGQKPY-KKMKGPEVMAFIEQGKRME 559 + APE + ++ D WS GV ++ LS G P+ + + I GK Sbjct: 306 TYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEHRTQVSLKDQITSGKYNF 364 Query: 560 CPP---ECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLAS 602 P E + L+ + + R E+ +R + Sbjct: 365 IPEVWAEVSEKALDLVKKLLVVDPKARFT---TEEALRHPWLQDED 407 >3TAC-A nrPDB Length = 361 Score = 217 bits (553), Expect = 1e-56, Method: Composition-based stats. Identities = 67/287 (23%), Positives = 116/287 (40%), Gaps = 25/287 (8%) Query: 335 DNLLIADI-----ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKA--DTEEMMREA 387 D++L D+ +G G F VR+ + R +Q V I + + T TE++ REA Sbjct: 20 DDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREA 79 Query: 388 QIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGK---REEIPVSNVAELLH 443 I H L +P+IV L+ ++ L +V E G L +V + + + + Sbjct: 80 SICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMR 139 Query: 444 QVSMGMKYLEEKNFVHRDLAARNVLLVNRHY---AKISDFGLSKALGADDSYYTARSAGK 500 Q+ ++Y + N +HRD+ VLL ++ K+ FG++ LG R Sbjct: 140 QILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVG-- 197 Query: 501 WPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMEC 560 + APE + + DVW GV ++ LS G P+ K + I +GK Sbjct: 198 -TPHFMAPEVVKREPYGKPVDVWGCGVILFILLS-GCLPFYGTK-ERLFEGIIKGKYKMN 254 Query: 561 P---PECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKV 604 P L+ + +R +TV + + + + Sbjct: 255 PRQWSHISESAKDLVRRMLMLDPAER---ITVYEALNHPWLKERDRY 298 >4WB7-A nrPDB Length = 405 Score = 217 bits (553), Expect = 1e-56, Method: Composition-based stats. Identities = 62/330 (18%), Positives = 123/330 (37%), Gaps = 27/330 (8%) Query: 255 PNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSV 314 P+ + + + L+ P++R E D + Sbjct: 32 PDKNKEPGAEEKFKEIAEAYDVLSDPRKREIFDRYGEEVKEFLAKAKEDFLK-------K 84 Query: 315 YESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG 374 +ESP + L D LG G+FG V ++ + I ++ Sbjct: 85 WESPAQNTAHL---------DQFERIKT-LGTGSFGRVMLVKHKETGNHYAMKILDKQKV 134 Query: 375 TEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEI 433 + E + E +I+ ++ P++V+L + L +VME GG + L + Sbjct: 135 VKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLR-RIGRF 193 Query: 434 PVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYY 493 + Q+ + +YL + ++RDL N+L+ + Y +++DFG +K + Sbjct: 194 SEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG----- 248 Query: 494 TARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIE 553 ++ APE I + ++ D W+ GV ++E + G P+ + ++ I Sbjct: 249 -RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEM-AAGYPPFFADQPIQIYEKIV 306 Query: 554 QGKRMECPPECPPELYALMSDCWIYKWEDR 583 GK + P +L L+ + R Sbjct: 307 SGK-VRFPSHFSSDLKDLLRNLLQVDLTKR 335 >4AW2-A nrPDB Length = 437 Score = 217 bits (553), Expect = 1e-56, Method: Composition-based stats. Identities = 67/293 (22%), Positives = 127/293 (43%), Gaps = 19/293 (6%) Query: 319 YSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--E 376 ++ P K K++ L R++ I + +G G FG V V +++ A+K+L + + Sbjct: 58 WAKPFTSKVKQMRLHREDFEILKV-IGRGAFGEV--AVVKLKNADKVFAMKILNKWEMLK 114 Query: 377 KADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPV 435 +A+T E ++ D+ +I L Q + L LVM+ GG L L + +P Sbjct: 115 RAETACFREERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPE 174 Query: 436 SNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTA 495 L ++ + + + + ++VHRD+ N+L+ + +++DFG L D + ++ Sbjct: 175 EMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSS 234 Query: 496 RSAGKWPLKWYAPECIN-----FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMA 550 + G + +PE + ++ D WS GV M+E L YG+ P+ E Sbjct: 235 VAVG--TPDYISPEILQAMEGGKGRYGPECDWWSLGVCMYEML-YGETPFYAESLVETYG 291 Query: 551 FIEQGK-RMECP---PECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYS 599 I K R + P + L+ + E R +E + ++S Sbjct: 292 KIMNHKERFQFPTQVTDVSENAKDLIRRLICSR-EHRLGQNGIEDFKKHPFFS 343 >3GUB-A nrPDB Length = 295 Score = 217 bits (553), Expect = 1e-56, Method: Composition-based stats. Identities = 67/297 (22%), Positives = 122/297 (41%), Gaps = 32/297 (10%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADT-----EEMMREAQI 389 D+ ELG G F V++ R + + A K +K+ K+ E++ RE I Sbjct: 10 DDYYDTGEELGSGQFAVVKKC--REKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSI 67 Query: 390 MHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMG 448 + ++ +P ++ L V + + ++L+ E+ GG L FL K E + E L Q+ G Sbjct: 68 LKEIQHPNVITLHEVYENKTDVILIGELVAGGELFDFLAEK-ESLTEEEATEFLKQILNG 126 Query: 449 MKYLEEKNFVHRDLAARNVLLVNRHY----AKISDFGLSKALGADDSYYTARSAGKWPLK 504 + YL H DL N++L++R+ KI DFGL+ + + + + Sbjct: 127 VYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEF----KNIFGTPE 182 Query: 505 WYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKR---MECP 561 + APE +N+ +D+WS GV + LS G P+ E +A + E Sbjct: 183 FVAPEIVNYEPLGLEADMWSIGVITYILLS-GASPFLGDTKQETLANVSAVNYEFEDEYF 241 Query: 562 PECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKAEAAC 618 + + + R ++ ++ + P TQ+A ++ Sbjct: 242 SNTSALAKDFIRRLLVKDPKKRMT---IQDSLQHPWI--------KPKDTQQALSSA 287 >2OU7-A nrPDB Length = 335 Score = 217 bits (552), Expect = 1e-56, Method: Composition-based stats. Identities = 56/257 (21%), Positives = 98/257 (38%), Gaps = 10/257 (3%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LG G F + K+ I + E+M E I L + ++V G Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 404 VCQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 + +V+E+ L + L +R+ + L Q+ +G +YL +HRDL Sbjct: 109 FFEDNDFVFVVLELCRRRSLLE-LHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDL 167 Query: 463 AARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDV 522 N+ L KI DFGL+ + D + + APE ++ + S DV Sbjct: 168 KLGNLFLNEDLEVKIGDFGLATKVEYDGE---RKKVLCGTPNYIAPEVLSKKGHSFEVDV 224 Query: 523 WSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWED 582 WS G M+ L G+ P++ E I++ + P P +L+ Sbjct: 225 WSIGCIMYTLL-VGKPPFETSCLKETYLRIKKNEY-SIPKHINPVAASLIQKMLQTDPTA 282 Query: 583 RPDFLTVEQRMRACYYS 599 RP + + + +++ Sbjct: 283 RPT---INELLNDEFFT 296 >6BDL-A nrPDB Length = 347 Score = 217 bits (552), Expect = 2e-56, Method: Composition-based stats. Identities = 71/256 (27%), Positives = 108/256 (42%), Gaps = 12/256 (4%) Query: 332 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG--TEKADTEEMMREAQI 389 LK + I D LG G FG V + + + A+K+LK+ + E + E QI Sbjct: 31 LKLSDFNIIDT-LGVGGFGRVELVQLKSEESKT-FAMKILKKRHIVDTRQQEHIRSEKQI 88 Query: 390 MHQLDNPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMG 448 M + +IVRL + + L ++ME GG L L R S V Sbjct: 89 MQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRD-RGSFEDSTTRFYTACVVEA 147 Query: 449 MKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 YL K ++RDL N++L +R YAK+ DFG +K +G +T ++ AP Sbjct: 148 FAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFC----GTPEYVAP 203 Query: 509 ECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM-ECPPECPPE 567 E I + +D WS G+ M+E L+ G P+ + I +G M E P + Sbjct: 204 EIILNKGHDISADYWSLGILMYELLT-GSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKN 262 Query: 568 LYALMSDCWIYKWEDR 583 L+ +R Sbjct: 263 AANLIKKLCRDNPSER 278 >5N23-A nrPDB Length = 352 Score = 216 bits (551), Expect = 2e-56, Method: Composition-based stats. Identities = 52/241 (21%), Positives = 103/241 (42%), Gaps = 9/241 (3%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LG G+FG V ++ + I ++ + E + E +I ++ P++V+L Sbjct: 50 LGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNFPFLVKLEF 109 Query: 404 VCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 + L +V+E A GG + L + + Q+ + +YL + ++RDL Sbjct: 110 SFKDNSNLYMVLEYAPGGEMFSHLR-RIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDL 168 Query: 463 AARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDV 522 N+L+ + Y K++DFG +K + + ++ APE I + ++ D Sbjct: 169 KPENLLIDQQGYIKVADFGFAKRVKGRTPWTL-----CGTPEYLAPEIILSKGYNKAVDW 223 Query: 523 WSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWED 582 W+ GV ++E + G P+ + ++ I GK + P +L L+ + Sbjct: 224 WALGVLIYEM-AAGYPPFFADQPIQIYEKIVSGK-VRFPSHFSSDLKDLLRNLLQVDLTK 281 Query: 583 R 583 R Sbjct: 282 R 282 >4J52-A nrPDB Length = 293 Score = 216 bits (551), Expect = 2e-56, Method: Composition-based stats. Identities = 56/257 (21%), Positives = 98/257 (38%), Gaps = 10/257 (3%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LG G F + K+ I + E+M E I L + ++V G Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 404 VCQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 + +V+E+ L + L +R+ + L Q+ +G +YL +HRDL Sbjct: 82 FFEDNDFVFVVLELCRRRSLLE-LHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDL 140 Query: 463 AARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDV 522 N+ L KI DFGL+ + D + + APE ++ + S DV Sbjct: 141 KLGNLFLNEDLEVKIGDFGLATKVEYDGE---RKKVLCGTPNYIAPEVLSKKGHSFEVDV 197 Query: 523 WSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWED 582 WS G M+ L G+ P++ E I++ + P P +L+ Sbjct: 198 WSIGCIMYTLL-VGKPPFETSCLKETYLRIKKNEY-SIPKHINPVAASLIQKMLQTDPTA 255 Query: 583 RPDFLTVEQRMRACYYS 599 RP + + + +++ Sbjct: 256 RPT---INELLNDEFFT 269 >6E2O-A nrPDB Length = 295 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 67/250 (26%), Positives = 107/250 (42%), Gaps = 15/250 (6%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 + LG G +G V G R Q+ +AIK + + + + E + L + IV+ Sbjct: 28 VVLGKGTYGIVYAG--RDLSNQVRIAIKEIPERDSRYSQP-LHEEIALHKHLKHKNIVQY 84 Query: 402 IGVCQAEALM-LVMEMAGGGPLHKFLVGKRE--EIPVSNVAELLHQVSMGMKYLEEKNFV 458 +G + + ME GG L L K + + Q+ G+KYL + V Sbjct: 85 LGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIV 144 Query: 459 HRDLAARNVLLVN-RHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF--RK 515 HRD+ NVL+ KISDFG SK L + + L++ APE I+ R Sbjct: 145 HRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTG---TLQYMAPEIIDKGPRG 201 Query: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPE-VMAFIEQGK-RMECPPECPPELYALMS 573 + +D+WS G T+ E + G+ P+ ++ P+ M + K E P E A + Sbjct: 202 YGKAADIWSLGCTIIEM-ATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFIL 260 Query: 574 DCWIYKWEDR 583 C+ + R Sbjct: 261 KCFEPDPDKR 270 >6HXF-B nrPDB Length = 302 Score = 216 bits (550), Expect = 3e-56, Method: Composition-based stats. Identities = 62/279 (22%), Positives = 122/279 (43%), Gaps = 20/279 (7%) Query: 326 KDKKLFLKRDNLLIADI-----ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADT 380 K ++ R +L ++ ELG G FG V + + ++ A KV++ +E+ + Sbjct: 4 KSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKA--KNKETGALAAAKVIETKSEE-EL 60 Query: 381 EEMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVA 439 E+ + E +I+ D+PYIV+L+G + L +++E GG + ++ + + Sbjct: 61 EDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQ 120 Query: 440 ELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAG 499 + Q+ + +L K +HRDL A NVL+ +++DFG+S + R + Sbjct: 121 VVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAK---NLKTLQKRDSF 177 Query: 500 KWPLKWYAPECINFR-----KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 554 W APE + + ++D+WS G+T+ E + + P+ ++ V+ I + Sbjct: 178 IGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEM-AQIEPPHHELNPMRVLLKIAK 236 Query: 555 GKRMEC--PPECPPELYALMSDCWIYKWEDRPDFLTVEQ 591 P + E + E RP + + Sbjct: 237 SDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLE 275 >4AGU-A nrPDB Length = 311 Score = 216 bits (549), Expect = 3e-56, Method: Composition-based stats. Identities = 68/296 (22%), Positives = 121/296 (40%), Gaps = 43/296 (14%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEM-MREAQIMHQLDNPYIVRL 401 ++G G++G V + R R VAIK + + +++ +RE +++ QL +P +V L Sbjct: 10 KIGEGSYGVVFKC--RNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNL 67 Query: 402 IGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 + V + + L LV E LH+ +R +P V + Q + + + N +HR Sbjct: 68 LEVFRRKRRLHLVFEYCDHTVLHELDRYQRG-VPEHLVKSITWQTLQAVNFCHKHNCIHR 126 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRKFSSR 519 D+ N+L+ K+ DFG ++ L YY A +W + +PE + ++ Sbjct: 127 DVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRW---YRSPELLVGDTQYGPP 183 Query: 520 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ--------------------GKRME 559 DVW+ G E LS G + + + I + G ++ Sbjct: 184 VDVWAIGCVFAELLS-GVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIP 242 Query: 560 CPPEC-PPELY---------ALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVE 605 P + P EL L+ C +R LT EQ + Y+ ++E Sbjct: 243 DPEDMEPLELKFPNISYPALGLLKGCLHMDPTER---LTCEQLLHHPYFENIREIE 295 >4NIF-A nrPDB Length = 333 Score = 216 bits (549), Expect = 3e-56, Method: Composition-based stats. Identities = 60/299 (20%), Positives = 118/299 (39%), Gaps = 30/299 (10%) Query: 336 NLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIM-HQLD 394 + + +G G++ ++ V++ ++ A+KV+ + E +I+ Sbjct: 8 DGYVVKETIGVGSYSECKRCVHKATN--MEYAVKVIDKSKRDPS-----EEIEILLRYGQ 60 Query: 395 NPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 +P I+ L V + + LV E+ GG L ++ ++ + +LH + ++YL Sbjct: 61 HPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKF-FSEREASFVLHTIGKTVEYLH 119 Query: 454 EKNFVHRDLAARNVL-LVNRHY---AKISDFGLSKALGADDSYYTARSAGKWPLKWYAPE 509 + VHRDL N+L + +I DFG +K L A++ + + APE Sbjct: 120 SQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLM---TPCYTANFVAPE 176 Query: 510 CINFRKFSSRSDVWSYGVTMWEALSYGQKPY---KKMKGPEVMAFIEQGKRMECPPE--- 563 + + + D+WS G+ ++ L+ G P+ E++ I GK Sbjct: 177 VLKRQGYDEGCDIWSLGILLYTMLA-GYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNT 235 Query: 564 CPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPP---GSTQKAEAACA 619 L+S R LT +Q ++ + + K+ Q + A A Sbjct: 236 VSETAKDLVSKMLHVDPHQR---LTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGAMA 291 >2J90-A nrPDB Length = 304 Score = 215 bits (548), Expect = 4e-56, Method: Composition-based stats. Identities = 63/279 (22%), Positives = 118/279 (42%), Gaps = 25/279 (8%) Query: 332 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADT-----EEMMRE 386 + D+ + + ELG G F VR+ + K+ A K +K+ + EE+ RE Sbjct: 23 MVEDHYEMGE-ELGSGQFAIVRKCRQKGTGKE--YAAKFIKKRRLSSSRRGVSREEIERE 79 Query: 387 AQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQV 445 I+ ++ +P I+ L + + + ++L++E+ GG L FL K E + + L Q+ Sbjct: 80 VNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEK-ESLTEDEATQFLKQI 138 Query: 446 SMGMKYLEEKNFVHRDLAARNVLLVNRHY----AKISDFGLSKALGADDSYYTARSAGKW 501 G+ YL K H DL N++L++++ K+ DFG++ + A + + Sbjct: 139 LDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEF----KNIFG 194 Query: 502 PLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM--- 558 ++ APE +N+ +D+WS GV + LS G P+ E + I Sbjct: 195 TPEFVAPEIVNYEPLGLEADMWSIGVITYILLS-GASPFLGETKQETLTNISAVNYDFDE 253 Query: 559 ECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACY 597 E + + + R + Q + + Sbjct: 254 EYFSNTSELAKDFIRRLLVKDPKRRMT---IAQSLEHSW 289 >4FIE-A nrPDB Length = 423 Score = 215 bits (548), Expect = 5e-56, Method: Composition-based stats. Identities = 74/384 (19%), Positives = 136/384 (35%), Gaps = 27/384 (7%) Query: 226 GTKFDTLWQ----LVEYLKLKADGLI--YCLKEACPNSSASNASGAAAPTLPAHPSTLTH 279 KF L + L+E + L+ C+ P + + G+ A L Sbjct: 26 EQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQPGAPKTIVRGSKGAKDGALTLLLDE 85 Query: 280 PQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKK-------LFL 332 + T ++ P + MP SP +P+ + ++ + Sbjct: 86 FENMSVTRSNSLRRDSPPPPARARQENGMPEKPPGPRSPQREPQRVSHEQFRAALQLVVD 145 Query: 333 KRDNLLIAD--IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIM 390 D D I++G G+ G V R K + V L++ + E + E IM Sbjct: 146 PGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRK---QQRRELLFNEVVIM 202 Query: 391 HQLDNPYIVRLIG-VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGM 449 + +V + + L +VME GG L + R + +A + V + Sbjct: 203 RDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR--MNEEQIAAVCLAVLQAL 260 Query: 450 KYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPE 509 L + +HRD+ + ++LL + K+SDFG + + + W APE Sbjct: 261 SVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVG---TPYWMAPE 317 Query: 510 CINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK--RMECPPECPPE 567 I+ + D+WS G+ + E + G+ PY + M I R++ + P Sbjct: 318 LISRLPYGPEVDIWSLGIMVIEMV-DGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPS 376 Query: 568 LYALMSDCWIYKWEDRPDFLTVEQ 591 L + + R + + Sbjct: 377 LKGFLDRLLVRDPAQRATAAELLK 400 >3NIZ-A nrPDB Length = 311 Score = 215 bits (548), Expect = 5e-56, Method: Composition-based stats. Identities = 62/243 (25%), Positives = 109/243 (44%), Gaps = 19/243 (7%) Query: 334 RDNLLIADI--------ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEM-M 384 R+NL + ++G G +G V + + VA+K ++ E + Sbjct: 11 RENLYFQGLMEKYQKLEKVGEGTYGVVYKAKD---SQGRIVALKRIRLDAEDEGIPSTAI 67 Query: 385 REAQIMHQLDNPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLH 443 RE ++ +L +P IV LI V +E L LV E L K L + + S + L+ Sbjct: 68 REISLLKELHHPNIVSLIDVIHSERCLTLVFEFMEK-DLKKVLDENKTGLQDSQIKIYLY 126 Query: 444 QVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPL 503 Q+ G+ + + +HRDL +N+L+ + K++DFGL++A G YT W Sbjct: 127 QLLRGVAHCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLW-- 184 Query: 504 KWYAPECINF-RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPP 562 + AP+ + +K+S+ D+WS G E ++ G+ + + + + I P Sbjct: 185 -YRAPDVLMGSKKYSTSVDIWSIGCIFAEMIT-GKPLFPGVTDDDQLPKIFSILGTPNPR 242 Query: 563 ECP 565 E P Sbjct: 243 EWP 245 >4KRC-A nrPDB Length = 317 Score = 215 bits (547), Expect = 6e-56, Method: Composition-based stats. Identities = 57/217 (26%), Positives = 101/217 (46%), Gaps = 14/217 (6%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 +LG G + +V +G+ + + VA+K +K +E+ +RE +M +L + IVRL Sbjct: 12 KLGNGTYATVYKGLNKTTG--VYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLY 69 Query: 403 GVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVS-----NVAELLHQVSMGMKYLEEKN 456 V E L LV E L K++ + V Q+ G+ + E Sbjct: 70 DVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENK 128 Query: 457 FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF-RK 515 +HRDL +N+L+ R K+ DFGL++A G + +++ W + AP+ + R Sbjct: 129 ILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLW---YRAPDVLMGSRT 185 Query: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI 552 +S+ D+WS G + E ++ G+ + E + I Sbjct: 186 YSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI 221 >6ED6-A nrPDB Length = 415 Score = 214 bits (546), Expect = 7e-56, Method: Composition-based stats. Identities = 70/353 (19%), Positives = 134/353 (37%), Gaps = 38/353 (10%) Query: 270 LPAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKK 329 +P + QR+++ L D +P +++ V + + + K+ Sbjct: 14 IPTTENLYFQGQRKLEALIRDPRSPINVESLLDG------LNSLVLDLDFPALRKNKNID 67 Query: 330 LFLKRDNLLIADIE--------------LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT 375 FL R ++ I +G G FG V+ ++ +K A+K+L + Sbjct: 68 NFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQK--VYAMKLLSKFE 125 Query: 376 --EKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREE 432 +++D+ E IM ++P++V+L Q + L +VME GG L + + Sbjct: 126 MIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLM--SNYD 183 Query: 433 IPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSY 492 +P +V + + + +HRD+ N+LL + K++DFG + D++ Sbjct: 184 VPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTC--MKMDETG 241 Query: 493 YTARSAGKWPLKWYAPECINFRK----FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEV 548 + +PE + + + D WS GV ++E L G P+ Sbjct: 242 MVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEML-VGDTPFYADSLVGT 300 Query: 549 MAFIEQGKRMECPP---ECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYY 598 + I K C P E L+ E R VE+ + ++ Sbjct: 301 YSKIMDHKNSLCFPEDAEISKHAKNLICAFLT-DREVRLGRNGVEEIRQHPFF 352 >5TOS-A nrPDB Length = 395 Score = 214 bits (545), Expect = 9e-56, Method: Composition-based stats. Identities = 72/305 (23%), Positives = 128/305 (41%), Gaps = 34/305 (11%) Query: 341 DIELGCGNFGSVRQGVYRMR-------KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL 393 D +G G FG V +G + +A+K L Q + E + E + QL Sbjct: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG-HREWLTEINYLGQL 128 Query: 394 DNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKR---EEIPVSNVAELLHQVSMGM 449 +P +V+LIG C + E +LV E G L L + + +P + + G+ Sbjct: 129 SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGL 188 Query: 450 KYLEEK--NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYA 507 +L ++RD+ A N+LL + AK+SDFGL++ D Y + + A Sbjct: 189 AFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM-GTYGYAA 247 Query: 508 PECINFRKFSSRSDVWSYGVTMWEALSYGQ-----------------KPYKKMKGPEVMA 550 PE ++ ++RSDV+S+GV + E LS + +PY +V+ Sbjct: 248 PEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLT-SKRKVLL 306 Query: 551 FIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPP-G 609 ++ + PE + ++ C ++ + RP V + ++ +L + P Sbjct: 307 IVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQTNPVK 366 Query: 610 STQKA 614 T+K Sbjct: 367 DTKKL 371 >4XBR-A nrPDB Length = 366 Score = 213 bits (543), Expect = 1e-55, Method: Composition-based stats. Identities = 54/253 (21%), Positives = 98/253 (38%), Gaps = 12/253 (4%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 I++G G+ G V R K + V L++ + E + E IM + +V + Sbjct: 100 IKIGEGSTGIVCIATVRSSGKLVAVKKMDLRK---QQRRELLFNEVVIMRDYQHENVVEM 156 Query: 402 IG-VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 + L +VME GG L + R + +A + V + L + +HR Sbjct: 157 YNSYLVGDELWVVMEFLEGGALTDIVTHTR--MNEEQIAAVCLAVLQALSVLHAQGVIHR 214 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRS 520 D+ + ++LL + K+SDFG + + + W APE I+ + Sbjct: 215 DIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVG---TPYWMAPELISRLPYGPEV 271 Query: 521 DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK--RMECPPECPPELYALMSDCWIY 578 D+WS G+ + E + G+ PY + M I R++ + P L + + Sbjct: 272 DIWSLGIMVIEMV-DGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVR 330 Query: 579 KWEDRPDFLTVEQ 591 R + + Sbjct: 331 DPAQRATAAELLK 343 >3UC3-A nrPDB Length = 361 Score = 213 bits (543), Expect = 2e-55, Method: Composition-based stats. Identities = 66/270 (24%), Positives = 107/270 (39%), Gaps = 20/270 (7%) Query: 330 LFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQI 389 + D ++G GNFG R ++ K+ VA+K +++G E + RE Sbjct: 15 IMHDSDRYDFVK-DIGSGNFGVARLMRDKLTKE--LVAVKYIERGAAID--ENVQREIIN 69 Query: 390 MHQLDNPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMG 448 L +P IVR V L ++ME A GG L++ + Q+ G Sbjct: 70 HRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERIC-NAGRFSEDEARFFFQQLLSG 128 Query: 449 MKYLEEKNFVHRDLAARNVLLVNR--HYAKISDFGLSKALGADDSYYTARSAGKWPLKWY 506 + Y HRDL N LL KI DFG SK ++ + + Sbjct: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSK----SSVLHSQPKSTVGTPAYI 184 Query: 507 APECINFRKFSSR-SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG---KRMECPP 562 APE + +++ + +DVWS GVT++ L G P++ + P Q + P Sbjct: 185 APEVLLRQEYDGKIADVWSCGVTLYVML-VGAYPFEDPEEPRDYRKTIQRILSVKYSIPD 243 Query: 563 E--CPPELYALMSDCWIYKWEDRPDFLTVE 590 + PE L+S ++ R ++ Sbjct: 244 DIRISPECCHLISRIFVADPATRISIPEIK 273 >2Q0N-A nrPDB Length = 301 Score = 213 bits (543), Expect = 2e-55, Method: Composition-based stats. Identities = 54/253 (21%), Positives = 98/253 (38%), Gaps = 12/253 (4%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 I++G G+ G V R K + V L++ + E + E IM + +V + Sbjct: 35 IKIGEGSTGIVCIATVRSSGKLVAVKKMDLRK---QQRRELLFNEVVIMRDYQHENVVEM 91 Query: 402 IG-VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 + L +VME GG L + R + +A + V + L + +HR Sbjct: 92 YNSYLVGDELWVVMEFLEGGALTDIVTHTR--MNEEQIAAVCLAVLQALSVLHAQGVIHR 149 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRS 520 D+ + ++LL + K+SDFG + + + W APE I+ + Sbjct: 150 DIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVG---TPYWMAPELISRLPYGPEV 206 Query: 521 DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK--RMECPPECPPELYALMSDCWIY 578 D+WS G+ + E + G+ PY + M I R++ + P L + + Sbjct: 207 DIWSLGIMVIEMV-DGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVR 265 Query: 579 KWEDRPDFLTVEQ 591 R + + Sbjct: 266 DPAQRATAAELLK 278 >5YV8-A nrPDB Length = 298 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 62/288 (21%), Positives = 120/288 (41%), Gaps = 42/288 (14%) Query: 336 NLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT-------------------- 375 N E+G G++G V+ A+KVL + Sbjct: 13 NQYTLKDEIGKGSYGVVKLAYN--ENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAP 70 Query: 376 -----EKADTEEMMREAQIMHQLDNPYIVRLIGVCQA---EALMLVMEMAGGGPLHKFLV 427 + E++ +E I+ +LD+P +V+L+ V + L +V E+ GP+ + V Sbjct: 71 GGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVME--V 128 Query: 428 GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALG 487 + + + G++YL + +HRD+ N+L+ + KI+DFG+S Sbjct: 129 PTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK 188 Query: 488 ADDSYYTARSAGKWPLKWYAPECINFRK--FSSRS-DVWSYGVTMWEALSYGQKPYKKMK 544 D+ + + APE ++ + FS ++ DVW+ GVT++ +GQ P+ + Sbjct: 189 GSDALLSNTVG---TPAFMAPESLSETRKIFSGKALDVWAMGVTLY-CFVFGQCPFMDER 244 Query: 545 GPEVMAFIEQGKRMECP--PECPPELYALMSDCWIYKWEDRPDFLTVE 590 + + I+ +E P P+ +L L++ E R ++ Sbjct: 245 IMCLHSKIKSQA-LEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK 291 >4KS7-A nrPDB Length = 292 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 54/258 (20%), Positives = 106/258 (41%), Gaps = 12/258 (4%) Query: 337 LLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNP 396 LL + +++G G+ G V + +Q+ V + L++ + E + E IM + Sbjct: 24 LLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRK---QQRRELLFNEVVIMRDYQHF 80 Query: 397 YIVRLI-GVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK 455 +V + E L ++ME GG L + R + +A + V + YL + Sbjct: 81 NVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVR--LNEEQIATVCEAVLQALAYLHAQ 138 Query: 456 NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK 515 +HRD+ + ++LL K+SDFG + D + W APE I+ Sbjct: 139 GVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVG---TPYWMAPEVISRSL 195 Query: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG--KRMECPPECPPELYALMS 573 +++ D+WS G+ + E + G+ PY + M + +++ + P L + Sbjct: 196 YATEVDIWSLGIMVIEMV-DGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLE 254 Query: 574 DCWIYKWEDRPDFLTVEQ 591 + ++R + Sbjct: 255 RMLVRDPQERATAQELLD 272 >4JDH-A nrPDB Length = 346 Score = 212 bits (541), Expect = 3e-55, Method: Composition-based stats. Identities = 54/253 (21%), Positives = 98/253 (38%), Gaps = 12/253 (4%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 I++G G+ G V R K + V L++ + E + E IM + +V + Sbjct: 80 IKIGEGSTGIVCIATVRSSGKLVAVKKMDLRK---QQRRELLFNEVVIMRDYQHENVVEM 136 Query: 402 IG-VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 + L +VME GG L + R + +A + V + L + +HR Sbjct: 137 YNSYLVGDELWVVMEFLEGGALTDIVTHTR--MNEEQIAAVCLAVLQALSVLHAQGVIHR 194 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRS 520 D+ + ++LL + K+SDFG + + + W APE I+ + Sbjct: 195 DIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVG---TPYWMAPELISRLPYGPEV 251 Query: 521 DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK--RMECPPECPPELYALMSDCWIY 578 D+WS G+ + E + G+ PY + M I R++ + P L + + Sbjct: 252 DIWSLGIMVIEMV-DGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVR 310 Query: 579 KWEDRPDFLTVEQ 591 R + + Sbjct: 311 DPAQRATAAELLK 323 >5WAX-A nrPDB Length = 310 Score = 211 bits (538), Expect = 6e-55, Method: Composition-based stats. Identities = 67/271 (24%), Positives = 104/271 (38%), Gaps = 20/271 (7%) Query: 330 LFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQI 389 + D + ++G GNFG R R + VA+K +++G + E + RE Sbjct: 6 IMHDGDRYELVR-DIGSGNFGVARLMRNRADGQ--LVAVKYIERGEKID--ENVQREIIN 60 Query: 390 MHQLDNPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMG 448 L +P I+R V L +VME A GG L + + Q+ G Sbjct: 61 HRSLRHPNIIRFKEVILTPTHLAIVMEYASGGELFERIC-NAGRFSEDEARFFFQQLISG 119 Query: 449 MKYLEEKNFVHRDLAARNVLLVNR--HYAKISDFGLSKALGADDSYYTARSAGKWPLKWY 506 + Y HRDL N LL KI DFG SK ++ + + Sbjct: 120 VSYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSK----SSVLHSQPKSTVGTPAYI 175 Query: 507 APECINFRKFSSRS-DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ---GKRMECPP 562 APE + +++ + DVWS GVT++ L G P++ P+ Q G + P Sbjct: 176 APEVLLKKEYDGKVADVWSCGVTLYVML-VGAYPFEDPDEPKNFRKTIQRILGVQYSIPD 234 Query: 563 --ECPPELYALMSDCWIYKWEDRPDFLTVEQ 591 PE L+S ++ R + Sbjct: 235 YVHISPECQDLISRIFVANPATRITIPEIRN 265 >5D7A-A nrPDB Length = 308 Score = 211 bits (538), Expect = 7e-55, Method: Composition-based stats. Identities = 64/269 (23%), Positives = 107/269 (39%), Gaps = 26/269 (9%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL-DNPYIVRLI 402 +G G +G V +G R K AIKV+ + EE+ +E ++ + + I Sbjct: 25 VGNGTYGQVYKG--RHVKTGQLAAIKVM--DVTGDEEEEIKQEINMLKKYSHHRNIATYY 80 Query: 403 GVC-------QAEALMLVMEMAGGGPLHKFLVG-KREEIPVSNVAELLHQVSMGMKYLEE 454 G + L LVME G G + + K + +A + ++ G+ +L + Sbjct: 81 GAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 140 Query: 455 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR 514 +HRD+ +NVLL K+ DFG+S L D R+ W APE I Sbjct: 141 HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQL---DRTVGRRNTFIGTPYWMAPEVIACD 197 Query: 515 K-----FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMEC-PPECPPEL 568 + + +SD+WS G+T E + G P M + I + + + Sbjct: 198 ENPDATYDFKSDLWSLGITAIEM-AEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKF 256 Query: 569 YALMSDCWIYKWEDRPDFLTVEQRMRACY 597 + + C + RP EQ M+ + Sbjct: 257 QSFIESCLVKNHSQRP---ATEQLMKHPF 282 >2X4F-A nrPDB Length = 373 Score = 211 bits (537), Expect = 7e-55, Method: Composition-based stats. Identities = 75/361 (20%), Positives = 139/361 (38%), Gaps = 24/361 (6%) Query: 260 SNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPY 319 N + S H + + N+D P R + + P Sbjct: 17 ENLYFQSMKNSGDQDSRSGHNEAKEVWSNADLTERMPV-----KSKRTSALAVDIPAPPA 71 Query: 320 SDPEELKDKKLFLKRDNLLIADIEL-GCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKA 378 + K ++ E+ G G FG V + + +A K++K K Sbjct: 72 PFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQVHKCE--ETATGLKLAAKIIKTRGMK- 128 Query: 379 DTEEMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSN 437 D EE+ E +M+QLD+ +++L +++ ++LVME GG L ++ + + + Sbjct: 129 DKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELD 188 Query: 438 VAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRH--YAKISDFGLSKALGADDSYYTA 495 + Q+ G++++ + +H DL N+L VNR KI DFGL++ + Sbjct: 189 TILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVN 248 Query: 496 RSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG 555 ++ APE +N+ S +D+WS GV + LS G P+ E + I Sbjct: 249 F----GTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLS-GLSPFLGDNDAETLNNILAC 303 Query: 556 K---RMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQ 612 + E + E +S I + R + ++ + S K+ + + Sbjct: 304 RWDLEDEEFQDISEEAKEFISKLLIKEKSWRISAS---EALKHPWLS-DHKLHSRLSAQK 359 Query: 613 K 613 K Sbjct: 360 K 360 >5UIU-A nrPDB Length = 323 Score = 211 bits (536), Expect = 9e-55, Method: Composition-based stats. Identities = 70/319 (21%), Positives = 132/319 (41%), Gaps = 31/319 (9%) Query: 299 ITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYR 358 + + + + + + + S ELK+ + + ++G G FG V +G Sbjct: 12 LYFQGENKSLEVSDTRFHSFSFY--ELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVN 69 Query: 359 MRKKQIDVAIKVLK---QGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQA-EALMLVM 414 VA+K L T + ++ +E ++M + + +V L+G + L LV Sbjct: 70 NT----TVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVY 125 Query: 415 EMAGGGPLHKFLVGKREEIPVSN--VAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNR 472 G L L P+S ++ + G+ +L E + +HRD+ + N+LL Sbjct: 126 VYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEA 185 Query: 473 HYAKISDFGLSKALGA-DDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWE 531 AKISDFGL++A + T+R G + APE + + +SD++S+GV + E Sbjct: 186 FTAKISDFGLARASEKFAQTVMTSRIVG--TTAYMAPEALRGE-ITPKSDIYSFGVVLLE 242 Query: 532 ALSYGQKPYKKMKGPEVMAF--------------IEQGKRMECPPECPPELYALMSDCWI 577 ++ G + + P+++ K + +Y++ S C Sbjct: 243 IIT-GLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLH 301 Query: 578 YKWEDRPDFLTVEQRMRAC 596 K RPD V+Q ++ Sbjct: 302 EKKNKRPDIKKVQQLLQEM 320 >6GU6-A nrPDB Length = 302 Score = 210 bits (535), Expect = 1e-54, Method: Composition-based stats. Identities = 64/297 (21%), Positives = 121/297 (40%), Gaps = 42/297 (14%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEM-MREAQIMHQLDNPYIVRL 401 ++G G +G V +G ++ + VA+K ++ +E+ +RE ++ +L +P IV L Sbjct: 14 KIGEGTYGVVYKGRHKTTGQ--VVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 71 Query: 402 IGVC-QAEALMLVMEMAGGGPLHKFL--VGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 V Q L L+ E L K+L + + + S V L+Q+ G+ + + + Sbjct: 72 QDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVL 130 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR-KFS 517 HRDL +N+L+ ++ K++DFGL++A G YT W + +PE + ++S Sbjct: 131 HRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLW---YRSPEVLLGSARYS 187 Query: 518 SRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI-----------------EQGKRMEC 560 + D+WS G E + + + + + I Q + Sbjct: 188 TPVDIWSIGTIFAELATK-KPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTF 246 Query: 561 PPECPPELYA-----------LMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEG 606 P P L + L+S IY R + L ++++ Sbjct: 247 PKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKR--ISGKMALNHPYFNDLDNQIKK 301 >1PHK-A nrPDB Length = 298 Score = 210 bits (534), Expect = 2e-54, Method: Composition-based stats. Identities = 56/262 (21%), Positives = 103/262 (39%), Gaps = 27/262 (10%) Query: 341 DIELGCGNFGSVRQGVYRMRKKQIDVAIKVL--------KQGTEKADTEEMMREAQIMHQ 392 LG G VR+ +++ K+ A+K++ + E ++E I+ + Sbjct: 22 KEILGRGVSSVVRRCIHKPTCKE--YAVKIIDVTGGGSFSAEEVQELREATLKEVDILRK 79 Query: 393 LD-NPYIVRLIGVCQAEALM-LVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMK 450 + +P I++L + LV ++ G L +L K + +++ + + Sbjct: 80 VSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEK-VTLSEKETRKIMRALLEVIC 138 Query: 451 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510 L + N VHRDL N+LL + K++DFG S L + + APE Sbjct: 139 ALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVC----GTPSYLAPEI 194 Query: 511 INFR------KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPP-- 562 I + D+WS GV M+ L+ G P+ K ++ I G P Sbjct: 195 IECSMNDNHPGYGKEVDMWSTGVIMYTLLA-GSPPFWHRKQMLMLRMIMSGNYQFGSPEW 253 Query: 563 -ECPPELYALMSDCWIYKWEDR 583 + + L+S + + + R Sbjct: 254 DDYSDTVKDLVSRFLVVQPQKR 275 >5WNL-A nrPDB Length = 342 Score = 210 bits (534), Expect = 2e-54, Method: Composition-based stats. Identities = 80/289 (27%), Positives = 129/289 (44%), Gaps = 21/289 (7%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 ++G G FG V + + K + AIK + + E++ EA+ M YI+ + Sbjct: 27 KVGSGGFGQVYKVRHVHWKTWL--AIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPV 84 Query: 402 IGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE--EKNFVH 459 G+CQ E + LVME G L K L E +P ++H+ ++GM +L +H Sbjct: 85 YGICQ-EPVGLVMEYMETGSLEKLLAS--EPLPWDLRFRIVHETAVGMNFLHCMSPPLLH 141 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK--FS 517 +L N+LL ++ KISDFGL+K G S+ + + + PE I + F Sbjct: 142 LNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKSRLFD 201 Query: 518 SRSDVWSYGVTMWEALSYGQKPYKKMKG-PEVMAFIEQGKRMECPPECPP------ELYA 570 ++ DV+S+ + +W L+ +KP+ K +M + +G R E PP C P L Sbjct: 202 TKHDVYSFAIVIWGVLTQ-KKPFADEKNILHIMMKVVKGHRPELPPICRPRPRACASLIG 260 Query: 571 LMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEG---PPGSTQKAEA 616 LM CW + RP F + +V+ PG E+ Sbjct: 261 LMQRCWHADPQVRPTFQEITSETEDLCEKPDEEVKDLAHEPGEKSSLES 309 >1VZO-A nrPDB Length = 355 Score = 209 bits (532), Expect = 3e-54, Method: Composition-based stats. Identities = 64/261 (24%), Positives = 114/261 (43%), Gaps = 18/261 (6%) Query: 335 DNLLIADIELGCGNFGSVRQGVYR-MRKKQIDVAIKVLKQGT---EKADTEEMMREAQIM 390 +N + + LG G +G V A+KVLK+ T + TE E Q++ Sbjct: 54 ENFELLKV-LGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVL 112 Query: 391 HQL-DNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMG 448 + +P++V L Q E L L+++ GG L L +RE V + ++ + Sbjct: 113 EHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHL-SQRERFTEHEVQIYVGEIVLA 171 Query: 449 MKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 +++L + ++RD+ N+LL + + ++DFGLSK AD++ G +++ AP Sbjct: 172 LEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCG--TIEYMAP 229 Query: 509 ECINFR--KFSSRSDVWSYGVTMWEALSYGQKPY----KKMKGPEVMAFIEQGKRMECPP 562 + + D WS GV M+E L+ G P+ +K E+ I + + P Sbjct: 230 DIVRGGDSGHDKAVDWWSLGVLMYELLT-GASPFTVDGEKNSQAEISRRILKSE-PPYPQ 287 Query: 563 ECPPELYALMSDCWIYKWEDR 583 E L+ + + R Sbjct: 288 EMSALAKDLIQRLLMKDPKKR 308 >2YAB-A nrPDB Length = 361 Score = 209 bits (531), Expect = 4e-54, Method: Composition-based stats. Identities = 67/287 (23%), Positives = 123/287 (42%), Gaps = 24/287 (8%) Query: 333 KRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADT-----EEMMREA 387 K ++ ELG G F V++ R + ++ A K +K+ +A EE+ RE Sbjct: 9 KVEDFYDIGEELGSGQFAIVKKC--REKSTGLEYAAKFIKKRQSRASRRGVCREEIEREV 66 Query: 388 QIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVS 446 I+ Q+ +P I+ L V + ++L++E+ GG L FL K E + + Q+ Sbjct: 67 SILRQVLHPNIITLHDVYENRTDVVLILELVSGGELFDFLAQK-ESLSEEEATSFIKQIL 125 Query: 447 MGMKYLEEKNFVHRDLAARNVLLVNRH----YAKISDFGLSKALGADDSYYTARSAGKWP 502 G+ YL K H DL N++L++++ + K+ DFGL+ + + Sbjct: 126 DGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEF----KNIFGT 181 Query: 503 LKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM---E 559 ++ APE +N+ +D+WS GV + LS G P+ E +A I E Sbjct: 182 PEFVAPEIVNYEPLGLEADMWSIGVITYILLS-GASPFLGDTKQETLANITAVSYDFDEE 240 Query: 560 CPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEG 606 + + + + R LT+++ +R + + + Sbjct: 241 FFSQTSELAKDFIRKLLVKETRKR---LTIQEALRHPWITPVDTQQA 284 >4JG6-A nrPDB Length = 355 Score = 208 bits (530), Expect = 5e-54, Method: Composition-based stats. Identities = 53/263 (20%), Positives = 114/263 (43%), Gaps = 22/263 (8%) Query: 332 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMH 391 ++ + ++G G++ ++ +++ ++ A+K++ + +++ TEE+ E ++ Sbjct: 31 IQFTDGYEVKEDIGVGSYSVCKRCIHKATN--MEFAVKIIDK-SKRDPTEEI--EI-LLR 84 Query: 392 QLDNPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMK 450 +P I+ L V + + +V E+ GG L ++ ++ + +L ++ ++ Sbjct: 85 YGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKF-FSEREASAVLFTITKTVE 143 Query: 451 YLEEKNFVHRDLAARNVL-LVNRHY---AKISDFGLSKALGADDSYYTARSAGKWPLKWY 506 YL + VHRDL N+L + +I DFG +K L A++ + + Sbjct: 144 YLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLM---TPCYTANFV 200 Query: 507 APECINFRKFSSRSDVWSYGVTMWEALSYGQKPY---KKMKGPEVMAFIEQGKRMECPP- 562 APE + + + + D+WS GV ++ L+ G P+ E++A I GK Sbjct: 201 APEVLERQGYDAACDIWSLGVLLYTMLT-GYTPFANGPDDTPEEILARIGSGKFSLSGGY 259 Query: 563 --ECPPELYALMSDCWIYKWEDR 583 L+S R Sbjct: 260 WNSVSDTAKDLVSKMLHVDPHQR 282 >3ZDU-A nrPDB Length = 325 Score = 208 bits (530), Expect = 5e-54, Method: Composition-based stats. Identities = 58/302 (19%), Positives = 111/302 (36%), Gaps = 42/302 (13%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ++G G++G+V + ++ + VAIK+ + E++ + MRE + + Q + +V LI Sbjct: 10 KVGEGSYGTVMKCKHKNTGQ--IVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLVNLI 67 Query: 403 GVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 V Q + + LV E L + + + L Q+ + YL N +HRD Sbjct: 68 EVFRQKKKIHLVFEFIDHTVLDELQHYCHGLES-KRLRKYLFQILRAIDYLHSNNIIHRD 126 Query: 462 LAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPE-CINFRKFSSRS 520 + N+L+ K+ DFG ++ L A Y A +W + APE + + Sbjct: 127 IKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRW---YRAPELVLKDTSYGKPV 183 Query: 521 DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIE--------------------QGKRMEC 560 D+W+ G + E + G +++ I G + Sbjct: 184 DIWALGCMIIEM-ATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQ 242 Query: 561 ---PPECPPE-------LYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGS 610 P + L ++ C DR + + Y++ +E Sbjct: 243 VQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDL---LHHEYFTRDGFIEKFMPE 299 Query: 611 TQ 612 + Sbjct: 300 LK 301 >4AU8-A nrPDB Length = 296 Score = 208 bits (530), Expect = 6e-54, Method: Composition-based stats. Identities = 52/213 (24%), Positives = 98/213 (46%), Gaps = 9/213 (4%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEE-MMREAQIMHQLDNPYIVRL 401 ++G G +G+V + + R+ VA+K ++ + +RE ++ +L + IVRL Sbjct: 13 KIGEGTYGTVFKA--KNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRL 70 Query: 402 IGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 V ++ L LV E L K+ ++ V L Q+ G+ + +N +HR Sbjct: 71 HDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHR 129 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF-RKFSSR 519 DL +N+L+ K++DFGL++A G Y+A W + P+ + + +S+ Sbjct: 130 DLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW---YRPPDVLFGAKLYSTS 186 Query: 520 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI 552 D+WS G E + G+ + + + I Sbjct: 187 IDMWSAGCIFAELANAGRPLFPGNDVDDQLKRI 219 >1KOB-A nrPDB Length = 387 Score = 207 bits (528), Expect = 9e-54, Method: Composition-based stats. Identities = 67/304 (22%), Positives = 126/304 (41%), Gaps = 24/304 (7%) Query: 303 DKPRPMPMDT---SVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRM 359 D P+ D +++ P E+K ++ D I + ELG G FG V + V + Sbjct: 19 DGPKINDYDKFYEDIWKKYVPQPVEVKQGSVY---DYYDILE-ELGSGAFGVVHRCVEKA 74 Query: 360 RKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAE-ALMLVMEMAG 418 + + VA K + D + E IM+QL +P ++ L + + ++L++E Sbjct: 75 TGR-VFVA-KFINTPY-PLDKYTVKNEISIMNQLHHPKLINLHDAFEDKYEMVLILEFLS 131 Query: 419 GGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNR--HYAK 476 GG L + + ++ + V + Q G+K++ E + VH D+ N++ + K Sbjct: 132 GGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHEHSIVHLDIKPENIMCETKKASSVK 191 Query: 477 ISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYG 536 I DFGL+ L D+ ++ APE ++ +D+W+ GV + LS G Sbjct: 192 IIDFGLATKLNPDEIV----KVTTATAEFAAPEIVDREPVGFYTDMWAIGVLGYVLLS-G 246 Query: 537 QKPYKKMKGPEVMAFIEQG---KRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRM 593 P+ E + +++ + PE + + + R LTV + Sbjct: 247 LSPFAGEDDLETLQNVKRCDWEFDEDAFSSVSPEAKDFIKNLLQKEPRKR---LTVHDAL 303 Query: 594 RACY 597 + Sbjct: 304 EHPW 307 >3ZUT-A nrPDB Length = 362 Score = 207 bits (528), Expect = 9e-54, Method: Composition-based stats. Identities = 68/281 (24%), Positives = 109/281 (38%), Gaps = 23/281 (8%) Query: 320 SDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKAD 379 S P +L + D + ++G GNFG R + + VA+K +++G + Sbjct: 7 SGPMDLP---IMHDSDRYELVK-DIGSGNFGVARLMRDKQSNE--LVAVKYIERGEKID- 59 Query: 380 TEEMMREAQIMHQLDNPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNV 438 E + RE L +P IVR V L +VME A GG L + + Sbjct: 60 -ENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC-NAGRFSEDEA 117 Query: 439 AELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNR--HYAKISDFGLSKALGADDSYYTAR 496 Q+ G+ Y HRDL N LL KI FG SK ++ Sbjct: 118 RFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSK----SSVLHSQP 173 Query: 497 SAGKWPLKWYAPECINFRKFSSRS-DVWSYGVTMWEALSYGQKPYKKMKGPE-VMAFIEQ 554 + + APE + +++ + DVWS GVT++ L G P++ + P+ I + Sbjct: 174 KSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVML-VGAYPFEDPEEPKNFRKTIHR 232 Query: 555 GKRME--CPP--ECPPELYALMSDCWIYKWEDRPDFLTVEQ 591 ++ P PE L+S ++ R + Sbjct: 233 ILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRN 273 >3NYO-A nrPDB Length = 576 Score = 207 bits (527), Expect = 1e-53, Method: Composition-based stats. Identities = 63/331 (19%), Positives = 122/331 (36%), Gaps = 31/331 (9%) Query: 272 AHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLF 331 P + R++ T + P + + R +E P ++ Sbjct: 113 TGPDLIPEVPRQLVTNCTQRLEQGPCKDLFQELTRLT------HEYLSVAPFADYLDSIY 166 Query: 332 LKR-------------DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKA 378 R N LG G FG V R K K+ ++ Sbjct: 167 FNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRK 226 Query: 379 DTEEMMREAQIMHQLDNPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREE-IPVS 436 + E QI+ ++++ ++V L + +AL LV+ + GG L + + P + Sbjct: 227 GEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEA 286 Query: 437 NVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTAR 496 ++ G++ L + V+RDL N+LL + + +ISD GL+ + + Sbjct: 287 RAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI---- 342 Query: 497 SAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK 556 + + APE + +++ D W+ G ++E ++ GQ P+++ K +E+ Sbjct: 343 KGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLV 401 Query: 557 RMECPPECPPEL----YALMSDCWIYKWEDR 583 + E P E +L S +R Sbjct: 402 K-EVPEEYSERFSPQARSLCSQLLCKDPAER 431 >3A8W-A nrPDB Length = 345 Score = 207 bits (526), Expect = 1e-53, Method: Composition-based stats. Identities = 57/253 (22%), Positives = 114/253 (45%), Gaps = 21/253 (8%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG--TEKADTEEMMREAQIMHQL-DNPYIVR 400 +G G++ V R++K A+KV+K+ + D + + E + Q ++P++V Sbjct: 17 IGRGSYAKVLL--VRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVG 74 Query: 401 LIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 L Q E+ L V+E GG L + +R ++P + ++S+ + YL E+ ++ Sbjct: 75 LHSCFQTESRLFFVIEYVNGGDLMFHMQRQR-KLPEEHARFYSAEISLALNYLHERGIIY 133 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKA-LGADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 RDL NVLL + + K++D+G+ K L D+ T + APE + + Sbjct: 134 RDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFC----GTPNYIAPEILRGEDYGF 189 Query: 519 RSDVWSYGVTMWEALSYGQKPY--------KKMKGPEVMAFIEQGKRMECPPECPPELYA 570 D W+ GV M+E ++ G+ P+ + + + K++ P + + Sbjct: 190 SVDWWALGVLMFEMMA-GRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAAS 248 Query: 571 LMSDCWIYKWEDR 583 ++ ++R Sbjct: 249 VLKSFLNKDPKER 261 >6BXI-A nrPDB Length = 333 Score = 206 bits (525), Expect = 2e-53, Method: Composition-based stats. Identities = 65/296 (21%), Positives = 112/296 (37%), Gaps = 45/296 (15%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQIMHQLDNPYIV 399 +G G FG VR + A+K+L++ EK + E I+ + D+ ++V Sbjct: 12 KVIGRGAFGEVRLVQKKDTGH--VYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVV 69 Query: 400 RLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 ++ Q + L L+ME GG + L+ K + + + + + + + F+ Sbjct: 70 KMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKD-TLTEEETQFYIAETVLAIDSIHQLGFI 128 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARS--------------------- 497 HRD+ N+LL ++ + K+SDFGL L R+ Sbjct: 129 HRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAE 188 Query: 498 -----------AGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP 546 + + APE ++ D WS GV M+E L G P+ Sbjct: 189 TWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEML-IGYPPFCSETPQ 247 Query: 547 EVMAFIEQGKR-MECPPECPPELYA---LMSDCWIYKWEDRPDFLTVEQRMRACYY 598 E + K + PPE P A ++ C +WE R VE+ ++ Sbjct: 248 ETYKKVMNWKETLTFPPEVPISEKAKDLILRFCC--EWEHRIGAPGVEEIKSNSFF 301 >1G3N-A nrPDB Length = 326 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 66/321 (20%), Positives = 126/321 (39%), Gaps = 55/321 (17%) Query: 332 LKRDNLLIADI------ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT-EKADTEEMM 384 +++D L AD E+G G +G V + ++ VA+K ++ T E+ + Sbjct: 1 MEKDGLCRADQQYECVAEIGEGAYGKVFKARD-LKNGGRFVALKRVRVQTGEEGMPLSTI 59 Query: 385 REAQIMHQLD---NPYIVRLIGVCQ------AEALMLVMEMAGGGPLHKFLVGKREE-IP 434 RE ++ L+ +P +VRL VC L LV E L +L E +P Sbjct: 60 REVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVP 118 Query: 435 VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYT 494 + +++ Q+ G+ +L VHRDL +N+L+ + K++DFGL++ S+ Sbjct: 119 TETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY----SFQM 174 Query: 495 ARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 554 A ++ L + APE + +++ D+WS G E + ++ + + I Sbjct: 175 ALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMF-RRKPLFRGSSDVDQLGKILD 233 Query: 555 GKRMECPPECPPELY--------------------------ALMSDCWIYKWEDRPD-FL 587 + + P ++ L+ C + R + Sbjct: 234 VIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYS 293 Query: 588 TVE----QRMRACYYSLASKV 604 + Q + C +L S + Sbjct: 294 ALSHPYFQDLERCKENLDSHL 314 >5NGU-A nrPDB Length = 381 Score = 206 bits (524), Expect = 3e-53, Method: Composition-based stats. Identities = 51/216 (23%), Positives = 97/216 (44%), Gaps = 13/216 (6%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G G +G V + K + VAIK + + + +RE +I+ + + I+ + Sbjct: 50 IGEGAYGMVCSAYDNLNK--VRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGIND 107 Query: 404 VCQAEAL------MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNF 457 + +A + +V ++ L+K L K + + ++ L+Q+ G+KY+ N Sbjct: 108 IIRAPTIEQMKDVYIVQDLME-TDLYKLL--KTQHLSNDHICYFLYQILRGLKYIHSANV 164 Query: 458 VHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC-INFRKF 516 +HRDL N+LL KI DFGL++ D + + + APE +N + + Sbjct: 165 LHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGY 224 Query: 517 SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI 552 + D+WS G + E LS + + + + I Sbjct: 225 TKSIDIWSVGCILAEMLSN-RPIFPGKHYLDQLNHI 259 >1U5R-A nrPDB Length = 348 Score = 206 bits (523), Expect = 3e-53, Method: Composition-based stats. Identities = 67/266 (25%), Positives = 115/266 (43%), Gaps = 20/266 (7%) Query: 329 KLFLKRD-NLLIADI-ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADT--EEMM 384 +LF K D L +D+ E+G G+FG+V R + VAIK + ++++ ++++ Sbjct: 45 ELFFKDDPEKLFSDLREIGHGSFGAVYFA--RDVRNSEVVAIKKMSYSGKQSNEKWQDII 102 Query: 385 REAQIMHQLDNPYIVRLIGVCQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLH 443 +E + + +L +P ++ G E LVME G L ++ + +A + H Sbjct: 103 KEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCL-GSASDLLEVHKKPLQEVEIAAVTH 161 Query: 444 QVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPL 503 G+ YL N +HRD+ A N+LL K+ DFG + + +S+ Sbjct: 162 GALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFV-------GTP 214 Query: 504 KWYAPECI---NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMEC 560 W APE I + ++ + DVWS G+T E L+ + P M + I Q + Sbjct: 215 YWMAPEVILAMDEGQYDGKVDVWSLGITCIE-LAERKPPLFNMNAMSALYHIAQNESPAL 273 Query: 561 PPEC-PPELYALMSDCWIYKWEDRPD 585 + C +DRP Sbjct: 274 QSGHWSEYFRNFVDSCLQKIPQDRPT 299 >3UDB-A nrPDB Length = 317 Score = 206 bits (523), Expect = 3e-53, Method: Composition-based stats. Identities = 69/281 (24%), Positives = 112/281 (39%), Gaps = 23/281 (8%) Query: 320 SDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKAD 379 + P +L + D + ++G GNFG R + + VA+K +++G + Sbjct: 7 AGPMDLP---IMHDSDRYELVK-DIGAGNFGVARLMRDKQANE--LVAVKYIERGEKID- 59 Query: 380 TEEMMREAQIMHQLDNPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNV 438 E + RE L +P IVR V L +VME A GG L + + Sbjct: 60 -ENVKREIINHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERIC-NAGRFSEDEA 117 Query: 439 AELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNR--HYAKISDFGLSKALGADDSYYTAR 496 Q+ G+ Y HRDL N LL KI+DFG SKA ++ Sbjct: 118 RFFFQQLISGVSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKA----SVLHSQP 173 Query: 497 SAGKWPLKWYAPECINFRKFSSRS-DVWSYGVTMWEALSYGQKPYKKMKGPE-VMAFIEQ 554 + + APE + +++ + DVWS GVT++ L G P++ + P+ I + Sbjct: 174 KSAVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVML-VGAYPFEDPEEPKNFRKTIHR 232 Query: 555 GKRME--CPP--ECPPELYALMSDCWIYKWEDRPDFLTVEQ 591 ++ P PE L+S ++ R + Sbjct: 233 ILNVQYAIPDYVHISPECRHLISRIFVADPAKRISIPEIRN 273 >2VD5-A nrPDB Length = 412 Score = 206 bits (523), Expect = 3e-53, Method: Composition-based stats. Identities = 66/279 (23%), Positives = 116/279 (41%), Gaps = 21/279 (7%) Query: 319 YSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--E 376 +++P ++ K++ L+RD+ I + +G G F V V +M++ A+K++ + + Sbjct: 45 WAEPIVVRLKEVRLQRDDFEILKV-IGRGAFSEV--AVVKMKQTGQVYAMKIMNKWDMLK 101 Query: 377 KADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPV 435 + + E ++ D +I +L Q E L LVME GG L L E IP Sbjct: 102 RGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPA 161 Query: 436 SNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTA 495 L ++ M + + +VHRD+ N+LL + +++DFG L AD + + Sbjct: 162 EMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSL 221 Query: 496 RSAGKWPLKWYAPECIN-------FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEV 548 + G + +PE + + D W+ GV +E YGQ P+ E Sbjct: 222 VAVG--TPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMF-YGQTPFYADSTAET 278 Query: 549 MAFI---EQGKRMECPPE-CPPELYALMSDCWIYKWEDR 583 I ++ + E P E + E R Sbjct: 279 YGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCP-PETR 316 >4QTB-A nrPDB Length = 380 Score = 205 bits (522), Expect = 4e-53, Method: Composition-based stats. Identities = 58/304 (19%), Positives = 112/304 (36%), Gaps = 45/304 (14%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G G +G V +RK + VAIK + + + +RE QI+ + + ++ + Sbjct: 49 IGEGAYGMVSSAYDHVRKTR--VAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRD 106 Query: 404 VCQAEAL------MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNF 457 + +A L +V ++ L+K L K +++ ++ L+Q+ G+KY+ N Sbjct: 107 ILRASTLEAMRDVYIVQDLME-TDLYKLL--KSQQLSNDHICYFLYQILRGLKYIHSANV 163 Query: 458 VHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC-INFRKF 516 +HRDL N+L+ KI DFGL++ + + + + APE +N + + Sbjct: 164 LHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGY 223 Query: 517 SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI-------------------EQGKR 557 + D+WS G + E LS + + + + I + Sbjct: 224 TKSIDIWSVGCILAEMLSN-RPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYL 282 Query: 558 MECP-----------PECPPELYALMSDCWIYKWEDRPDFLT--VEQRMRACYYSLASKV 604 P P+ + L+ + R + Y V Sbjct: 283 QSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPV 342 Query: 605 EGPP 608 P Sbjct: 343 AEEP 346 >1ZWS-A nrPDB Length = 288 Score = 205 bits (522), Expect = 4e-53, Method: Composition-based stats. Identities = 65/287 (22%), Positives = 121/287 (42%), Gaps = 24/287 (8%) Query: 333 KRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADT-----EEMMREA 387 K ++ ELG G F V++ R + ++ A K +K+ +A EE+ RE Sbjct: 9 KVEDFYDIGEELGSGQFAIVKKC--REKSTGLEYAAKFIKKRQSRASRRGVSREEIEREV 66 Query: 388 QIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVS 446 I+ Q+ + ++ L V + ++L++E+ GG L FL K E + + Q+ Sbjct: 67 SILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQK-ESLSEEEATSFIKQIL 125 Query: 447 MGMKYLEEKNFVHRDLAARNVLLVNRH----YAKISDFGLSKALGADDSYYTARSAGKWP 502 G+ YL K H DL N++L++++ + K+ DFGL+ + + Sbjct: 126 DGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEF----KNIFGT 181 Query: 503 LKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM---E 559 ++ APE +N+ +D+WS GV + LS G P+ E +A I E Sbjct: 182 PEFVAPEIVNYEPLGLEADMWSIGVITYILLS-GASPFLGDTKQETLANITSVSYDFDEE 240 Query: 560 CPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEG 606 + + + R LT+++ +R + + + Sbjct: 241 FFSHTSELAKDFIRKLLVKETRKR---LTIQEALRHPWITPVDNQQA 284 >2A27-A nrPDB Length = 321 Score = 205 bits (522), Expect = 5e-53, Method: Composition-based stats. Identities = 65/287 (22%), Positives = 122/287 (42%), Gaps = 24/287 (8%) Query: 333 KRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADT-----EEMMREA 387 K ++ ELG G F V++ R + ++ A K +K+ +A EE+ RE Sbjct: 9 KVEDFYDIGEELGSGQFAIVKKC--REKSTGLEYAAKFIKKRQSRASRRGVSREEIEREV 66 Query: 388 QIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVS 446 I+ Q+ + ++ L V + ++L++E+ GG L FL K E + + Q+ Sbjct: 67 SILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQK-ESLSEEEATSFIKQIL 125 Query: 447 MGMKYLEEKNFVHRDLAARNVLLVNRH----YAKISDFGLSKALGADDSYYTARSAGKWP 502 G+ YL K H DL N++L++++ + K+ DFGL+ + + Sbjct: 126 DGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEF----KNIFGT 181 Query: 503 LKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM---E 559 ++ APE +N+ +D+WS GV + LS G P+ E +A I E Sbjct: 182 PEFVAPEIVNYEPLGLEADMWSIGVITYILLS-GASPFLGDTKQETLANITAVSYDFDEE 240 Query: 560 CPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEG 606 + + + + R LT+++ +R + + + Sbjct: 241 FFSQTSELAKDFIRKLLVKETRKR---LTIQEALRHPWITPVDNQQA 284 >1NY3-A nrPDB Length = 400 Score = 205 bits (522), Expect = 5e-53, Method: Composition-based stats. Identities = 68/297 (22%), Positives = 124/297 (41%), Gaps = 33/297 (11%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL- 393 D+ + LG G G V Q + +++ A+K+L D + RE ++ + Sbjct: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKF--ALKML------QDCPKARREVELHWRAS 112 Query: 394 DNPYIVRLIGVCQA-----EALMLVMEMAGGGPLHKFLVGK-REEIPVSNVAELLHQVSM 447 P+IVR++ V + + L++VME GG L + + + +E++ + Sbjct: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 Query: 448 GMKYLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKALGADDSYYTARSAGKWPLK 504 ++YL N HRD+ N+L + K++DFG +K + +S T + Sbjct: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTT----PCYTPY 228 Query: 505 WYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM---ECP 561 + APE + K+ D+WS GV M+ L G P+ G + ++ RM E P Sbjct: 229 YVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 Query: 562 ----PECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKA 614 E E+ L+ + + R + + M + ++KV P T + Sbjct: 288 NPEWSEVSEEVKMLIRNLLKTEPTQRMT---ITEFMNHPWIMQSTKVPQTPLHTSRV 341 >5LOH-A nrPDB Length = 341 Score = 205 bits (521), Expect = 5e-53, Method: Composition-based stats. Identities = 58/221 (26%), Positives = 93/221 (42%), Gaps = 16/221 (7%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQIMHQLDNPYIV 399 + G FG V G K A+KV+K+ K T ++ E + +P+IV Sbjct: 42 KPISRGAFGKVYLGQ----KGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIV 97 Query: 400 RLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 L Q+ + LVME GG + L + + +V++ + YL + Sbjct: 98 HLYYSLQSANNVYLVMEYLIGGDVKSLLHI-YGYFDEEMAVKYISEVALALDYLHRHGII 156 Query: 459 HRDLAARNVLLVNRHYAKISDFGLS-----KALGADDSYYTARSAGKWPLKWYAPECINF 513 HRDL N+L+ N + K++DFGLS + + D T G + APE + Sbjct: 157 HRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCG--TPDYLAPELLLG 214 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 554 R D W+ GV ++E L+ G P+ +V I + Sbjct: 215 RAHGPAVDWWALGVCLFEFLT-GIPPFNDETPQQVFQNILK 254 >2GCD-A nrPDB Length = 309 Score = 205 bits (521), Expect = 5e-53, Method: Composition-based stats. Identities = 67/266 (25%), Positives = 115/266 (43%), Gaps = 20/266 (7%) Query: 329 KLFLKRD-NLLIADI-ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADT--EEMM 384 +LF K D L +D+ E+G G+FG+V R + VAIK + ++++ ++++ Sbjct: 6 ELFFKDDPEKLFSDLREIGHGSFGAVYFA--RDVRNSEVVAIKKMSYSGKQSNEKWQDII 63 Query: 385 REAQIMHQLDNPYIVRLIGVCQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLH 443 +E + + +L +P ++ G E LVME G L ++ + +A + H Sbjct: 64 KEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCL-GSASDLLEVHKKPLQEVEIAAVTH 122 Query: 444 QVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPL 503 G+ YL N +HRD+ A N+LL K+ DFG + + +S+ Sbjct: 123 GALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFV-------GTP 175 Query: 504 KWYAPECI---NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMEC 560 W APE I + ++ + DVWS G+T E L+ + P M + I Q + Sbjct: 176 YWMAPEVILAMDEGQYDGKVDVWSLGITCIE-LAERKPPLFNMNAMSALYHIAQNESPAL 234 Query: 561 PPEC-PPELYALMSDCWIYKWEDRPD 585 + C +DRP Sbjct: 235 QSGHWSEYFRNFVDSCLQKIPQDRPT 260 >3ORZ-A nrPDB Length = 316 Score = 205 bits (521), Expect = 5e-53, Method: Composition-based stats. Identities = 56/252 (22%), Positives = 111/252 (44%), Gaps = 10/252 (3%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG--TEKADTEEMMREAQIMHQ 392 ++ I LG G+F +V ++ AIK+L++ ++ + RE +M + Sbjct: 37 EDFKFGKI-LGEGSFSTVVLARELATSRE--YAIKILEKRHIIKENKVPYVTRERDVMSR 93 Query: 393 LDNPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKY 451 LD+P+ V+L Q + L + A G L K++ K + ++ ++Y Sbjct: 94 LDHPFFVKLYFCFQDDEKLYFGLSYAKNGELLKYIR-KIGSFDETCTRFYTAEIVSALEY 152 Query: 452 LEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI 511 L K +HRDL N+LL + +I+DFG +K L + A S ++ +PE + Sbjct: 153 LHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFV-GTAQYVSPELL 211 Query: 512 NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYAL 571 + SD+W+ G +++ ++ G P++ + I + + + P + P+ L Sbjct: 212 TEKSACKSSDLWALGCIIYQLVA-GLPPFRAGNEYLIFQKIIKLEY-DFPEKFFPKARDL 269 Query: 572 MSDCWIYKWEDR 583 + + R Sbjct: 270 VEKLLVLDATKR 281 >1UA2-A nrPDB Length = 346 Score = 205 bits (521), Expect = 6e-53, Method: Composition-based stats. Identities = 51/216 (23%), Positives = 95/216 (43%), Gaps = 15/216 (6%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLK----QGTEKADTEEMMREAQIMHQLDNPYIV 399 LG G F +V + + + VAIK +K + +RE +++ +L +P I+ Sbjct: 18 LGEGQFATVYKARDKNTNQ--IVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNII 75 Query: 400 RLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 L+ + LV + L + + S++ + G++YL + + Sbjct: 76 GLLDAFGHKSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF-RKFS 517 HRDL N+LL K++DFGL+K+ G+ + YT + +W + APE + R + Sbjct: 135 HRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFGARMYG 191 Query: 518 SRSDVWSYGVTMWEALSYGQKPY-KKMKGPEVMAFI 552 D+W+ G + E L + P+ + + I Sbjct: 192 VGVDMWAVGCILAELLL--RVPFLPGDSDLDQLTRI 225 >2OZA-A nrPDB Length = 356 Score = 204 bits (520), Expect = 8e-53, Method: Composition-based stats. Identities = 68/297 (22%), Positives = 124/297 (41%), Gaps = 33/297 (11%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL- 393 D+ + LG G G V Q + +++ A+K+L D + RE ++ + Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKF--ALKML------QDCPKARREVELHWRAS 68 Query: 394 DNPYIVRLIGVCQA-----EALMLVMEMAGGGPLHKFLVGK-REEIPVSNVAELLHQVSM 447 P+IVR++ V + + L++VME GG L + + + +E++ + Sbjct: 69 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 128 Query: 448 GMKYLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKALGADDSYYTARSAGKWPLK 504 ++YL N HRD+ N+L + K++DFG +K + +S T + Sbjct: 129 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTT----PCYTPY 184 Query: 505 WYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM---ECP 561 + APE + K+ D+WS GV M+ L G P+ G + ++ RM E P Sbjct: 185 YVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFP 243 Query: 562 ----PECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKA 614 E E+ L+ + + R + + M + ++KV P T + Sbjct: 244 NPEWSEVSEEVKMLIRNLLKTEPTQRMT---ITEFMNHPWIMQSTKVPQTPLHTSRV 297 >3C51-A nrPDB Length = 543 Score = 204 bits (520), Expect = 8e-53, Method: Composition-based stats. Identities = 57/262 (21%), Positives = 108/262 (41%), Gaps = 13/262 (4%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 ++ + LG G FG V + K K+ ++ + M E +I+ ++ Sbjct: 184 EDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVH 243 Query: 395 NPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIP---VSNVAELLHQVSMGMK 450 + +IV L + + L LVM + GG + + E+ P Q+ G++ Sbjct: 244 SRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLE 303 Query: 451 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510 +L ++N ++RDL NVLL + +ISD GL+ L A T + APE Sbjct: 304 HLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAG---QTKTKGYAGTPGFMAPEL 360 Query: 511 INFRKFSSRSDVWSYGVTMWEALSYGQKPY----KKMKGPEVMAFIEQGKRMECPPECPP 566 + ++ D ++ GVT++E ++ + P+ +K++ E+ + + + P + P Sbjct: 361 LLGEEYDFSVDYFALGVTLYEMIAA-RGPFRARGEKVENKELKQRVLEQA-VTYPDKFSP 418 Query: 567 ELYALMSDCWIYKWEDRPDFLT 588 E R F Sbjct: 419 ASKDFCEALLQKDPEKRLGFRD 440 >3KA0-A nrPDB Length = 320 Score = 204 bits (519), Expect = 9e-53, Method: Composition-based stats. Identities = 67/297 (22%), Positives = 124/297 (41%), Gaps = 33/297 (11%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL- 393 D+ + LG G G V Q + +++ A+K+L D + RE ++ + Sbjct: 15 DDYKVTSQVLGLGINGKVLQIFNKRTQEKF--ALKML------QDCPKARREVELHWRAS 66 Query: 394 DNPYIVRLIGVCQA-----EALMLVMEMAGGGPLHKFLVGK-REEIPVSNVAELLHQVSM 447 P+IVR++ V + + L++VME GG L + + + +E++ + Sbjct: 67 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 126 Query: 448 GMKYLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKALGADDSYYTARSAGKWPLK 504 ++YL N HRD+ N+L + K++DFG +K + +S + + Sbjct: 127 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSL----TEPCYTPY 182 Query: 505 WYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM---ECP 561 + APE + K+ D+WS GV M+ L G P+ G + ++ RM E P Sbjct: 183 YVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFP 241 Query: 562 ----PECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKA 614 E E+ L+ + + R + + M + ++KV P T + Sbjct: 242 NPEWSEVSEEVKMLIRNLLKTEPTQRMT---ITEFMNHPWIMQSTKVPQTPLHTSRV 295 >6CQF-A nrPDB Length = 297 Score = 204 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 60/273 (21%), Positives = 110/273 (40%), Gaps = 19/273 (6%) Query: 323 EELKDKKLFL--KRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADT 380 ++ D +F RD+ + LG G +G V + ++ VA+K++K + D Sbjct: 2 SDVVDPDIFNRDPRDHYDLL-QRLGGGTYGEVFKARDKVSGD--LVALKMVKMEPD-DDV 57 Query: 381 EEMMREAQIMHQLDNPYIVRLIG-VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVA 439 + +E I+ + IV G + L + ME G G L + + ++ Sbjct: 58 STLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQD-IYQVTGSLSELQIS 116 Query: 440 ELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAG 499 + +V G+ YL + +HRD+ N+L+ + +++DFG+S +GA R A Sbjct: 117 YVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGAT---LARRLAF 173 Query: 500 KWPLKWYAPE---CINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI-EQG 555 W APE ++ D+WS G+T E L+ Q P + V+ + + G Sbjct: 174 IGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIE-LAELQPPLFDVHPLRVLFLMTKSG 232 Query: 556 KRMECPPEC---PPELYALMSDCWIYKWEDRPD 585 + E + + + RP Sbjct: 233 YQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPS 265 >4C0T-A nrPDB Length = 974 Score = 202 bits (515), Expect = 3e-52, Method: Composition-based stats. Identities = 56/347 (16%), Positives = 130/347 (37%), Gaps = 23/347 (6%) Query: 275 STLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPM------DTSVYESPYSDPEELKDK 328 + +S+ + D +P + +E + + +K Sbjct: 195 DQTPPNESVERFDDSNNTVDNTEEEENNDDTDEIPKSETLKQNEENWEKKGAAVKTIKTM 254 Query: 329 KLFLKRDNLLIAD----IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMM 384 +K + D ELG G++ +V ++ KQ V + + ++ + + Sbjct: 255 DGEMKTIRRNVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVN 314 Query: 385 REAQIMHQLDNP-YIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELL 442 E +++L N ++ L Q ++L V++ A G L L+ + + Sbjct: 315 IEKHALNRLSNRLGVISLYFTFQDKDSLYFVLDYASNGELLT-LIKRYNTLNEECTRHFG 373 Query: 443 HQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTAR------ 496 Q+ +KY+ + +HRDL N+LL ++ +I+DFG ++ L + Sbjct: 374 AQILDAIKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRA 433 Query: 497 SAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK 556 + ++ +PE + + DVW++G +++ ++ G+ P+K I + Sbjct: 434 KSFVGTAEYVSPELLENKYCGKPGDVWAFGCIIYQMIA-GKPPFKATNEYLTFQKITK-L 491 Query: 557 RMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASK 603 + P + L+ + + R +++ + S+ K Sbjct: 492 QFAFSAGFPTIIRDLIKKILVLQPSRRATIPEIQK--HYFFQSVDFK 536 >5J5T-A nrPDB Length = 370 Score = 202 bits (515), Expect = 3e-52, Method: Composition-based stats. Identities = 67/287 (23%), Positives = 110/287 (38%), Gaps = 27/287 (9%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 +G G +G V + R AIKV+K + D + +E +M +P IV Sbjct: 10 QRIGSGTYGDVYKA--RNVNTGELAAIKVIKLEPGE-DFAVVQQEIIMMKDCKHPNIVAY 66 Query: 402 IG-VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 G + + L + ME GGG L + + +A + + G+ YL K +HR Sbjct: 67 FGSYLRRDKLWICMEFCGGGSLQD-IYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHR 125 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI---NFRKFS 517 D+ N+LL + + K++DFG+S + A R A W APE ++ Sbjct: 126 DIKGANILLTDNGHVKLADFGVSAQITAT---IAKRKAFIGTPYWMAPEVAAVERKGGYN 182 Query: 518 SRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPEC------PPELYAL 571 D+W+ G+T E L+ Q P + + + + PP+ + Sbjct: 183 QLCDLWAVGITAIE-LAELQPPMFDLHPMRALFLMTKSN--FQPPKLKDKMKWSNSFHHF 239 Query: 572 MSDCWIYKWEDRPDFLTVEQ-------RMRACYYSLASKVEGPPGST 611 + + RP + Q R+ L KV P ST Sbjct: 240 VKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHST 286 >5EFQ-A nrPDB Length = 347 Score = 202 bits (515), Expect = 3e-52, Method: Composition-based stats. Identities = 60/280 (21%), Positives = 114/280 (40%), Gaps = 24/280 (8%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTE-EMMREAQIMHQL 393 D I I +G G +G V + + + VA+K ++ EK +RE +I+ QL Sbjct: 11 DKFDIIGI-IGEGTYGQVYKARDKDTGEM--VALKKVRLDNEKEGFPITAIREIKILRQL 67 Query: 394 DNPYIVRLIGVCQAEA-----------LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELL 442 + I+ + + + LV E L L +++ + Sbjct: 68 THQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDH-DLMGLLESGLVHFNENHIKSFM 126 Query: 443 HQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWP 502 Q+ G+ Y +KNF+HRD+ N+LL NR K++DFGL++ +++S + Sbjct: 127 RQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEES--RPYTNKVIT 184 Query: 503 LKWYAPECINF-RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECP 561 L + PE + +++ DVWS G + E + + ++ + + I + CP Sbjct: 185 LWYRPPELLLGEERYTPAIDVWSCGCILGELFTK-KPIFQANQELAQLELISRICGSPCP 243 Query: 562 PECPPELY----ALMSDCWIYKWEDRPDFLTVEQRMRACY 597 P + M Y+ + R +F+ + + Sbjct: 244 AVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLF 283 >4B8L-A nrPDB Length = 286 Score = 202 bits (515), Expect = 3e-52, Method: Composition-based stats. Identities = 69/270 (25%), Positives = 111/270 (41%), Gaps = 14/270 (5%) Query: 325 LKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTE-E 382 + K D+ I LG G FG+V R ++ + +A+KVL K EK E + Sbjct: 5 AEMPKRKFTIDDFDIGR-PLGKGKFGNVYLA--REKQNKFIMALKVLFKSQLEKEGVEHQ 61 Query: 383 MMREAQIMHQLDNPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAEL 441 + RE +I L +P I+R+ + + L++E A G L+K L K A Sbjct: 62 LRREIEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKEL-QKHGRFDEQRSATF 120 Query: 442 LHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKW 501 + +++ + Y E+ +HRD+ N+L+ + KI+DFG S + R Sbjct: 121 MEELADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPS-----LRRRTMCG 175 Query: 502 PLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECP 561 L + PE I + + D+W GV +E L G P+ E I ++ P Sbjct: 176 TLDYLPPEMIEGKTHDEKVDLWCAGVLCYEFL-VGMPPFDSPSHTETHRRIVN-VDLKFP 233 Query: 562 PECPPELYALMSDCWIYKWEDRPDFLTVEQ 591 P L+S Y R V + Sbjct: 234 PFLSDGSKDLISKLLRYHPPQRLPLKGVME 263 >3HNG-A nrPDB Length = 360 Score = 202 bits (515), Expect = 3e-52, Method: Composition-based stats. Identities = 61/168 (36%), Positives = 97/168 (57%), Gaps = 2/168 (1%) Query: 430 REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD 489 +E I + ++ QV+ GM++L + +HRDLAARN+LL + KI DFGL++ + Sbjct: 193 KEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYK- 251 Query: 490 DSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMK-GPEV 548 + Y + + PLKW APE I + +S++SDVWSYGV +WE S G PY ++ + Sbjct: 252 NPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDF 311 Query: 549 MAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRAC 596 + + +G RM P PE+Y +M DCW ++RP F + +++ Sbjct: 312 CSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDL 359 Score = 99.7 bits (247), Expect = 3e-21, Method: Composition-based stats. Identities = 36/133 (27%), Positives = 60/133 (45%), Gaps = 13/133 (9%) Query: 305 PRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVY---RMRK 361 P +P+D PY K R+ L + LG G FG V Q + Sbjct: 3 PDEVPLDEQCERLPYD------ASKWEFARERLKLGKS-LGRGAFGKVVQASAFGIKKSP 55 Query: 362 KQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNP-YIVRLIGVCQAEA--LMLVMEMAG 418 VA+K+LK+G ++ + +M E +I+ + + +V L+G C + LM+++E Sbjct: 56 TCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCK 115 Query: 419 GGPLHKFLVGKRE 431 G L +L KR+ Sbjct: 116 YGNLSNYLKSKRD 128 >4EWQ-A nrPDB Length = 383 Score = 202 bits (515), Expect = 3e-52, Method: Composition-based stats. Identities = 55/252 (21%), Positives = 109/252 (43%), Gaps = 23/252 (9%) Query: 312 TSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVL 371 + E P +EL + ++ +G G +GSV K + VA+K L Sbjct: 23 NASQERPTFYRQELNKTIWEVPERYQNLS--PVGSGAYGSVCAAFD--TKTGLRVAVKKL 78 Query: 372 KQGTEKA-DTEEMMREAQIMHQLDNPYIVRLIGVC-------QAEALMLVMEMAGGGPLH 423 + + + RE +++ + + ++ L+ V + + LV + G L+ Sbjct: 79 SRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLN 137 Query: 424 KFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLS 483 + K +++ +V L++Q+ G+KY+ + +HRDL N+ + KI DFGL+ Sbjct: 138 NIV--KCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLA 195 Query: 484 KALGADDSYYTARSAGKWPLKWYAPEC-INFRKFSSRSDVWSYGVTMWEALSYGQKPYKK 542 + + + Y A + APE +N+ ++ D+WS G M E L+ G+ + Sbjct: 196 RHTDDEMTGYVA------TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPG 248 Query: 543 MKGPEVMAFIEQ 554 + + I + Sbjct: 249 TDHIDQLKLILR 260 >4AN9-A nrPDB Length = 301 Score = 202 bits (514), Expect = 4e-52, Method: Composition-based stats. Identities = 72/266 (27%), Positives = 131/266 (49%), Gaps = 21/266 (7%) Query: 331 FLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIM 390 LK D+ ELG GN G V + ++ + +A K++ + A +++RE Q++ Sbjct: 5 ELKDDDFEKIS-ELGAGNGGVVFKVSHKPSG--LVMARKLIHLEIKPAIRNQIIRELQVL 61 Query: 391 HQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGM 449 H+ ++PYIV G ++ + + ME GG L + L K IP + ++ V G+ Sbjct: 62 HECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL-KKAGRIPEQILGKVSIAVIKGL 120 Query: 450 KYLEEKN-FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 YL EK+ +HRD+ N+L+ +R K+ DFG+S L + + + + +P Sbjct: 121 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMA-----NEFVGTRSYMSP 175 Query: 509 ECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPEL 568 E + +S +SD+WS G+++ E + G+ P M E++ +I E PP+ P + Sbjct: 176 ERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPRPPMAIFELLDYIVN----EPPPKLPSAV 230 Query: 569 YAL-----MSDCWIYKWEDRPDFLTV 589 ++L ++ C I +R D + Sbjct: 231 FSLEFQDFVNKCLIKNPAERADLKQL 256 >2BRG-A nrPDB Length = 297 Score = 201 bits (512), Expect = 6e-52, Method: Composition-based stats. Identities = 60/253 (23%), Positives = 105/253 (41%), Gaps = 9/253 (3%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LG G +G V+ V R+ ++ VA+K++ E + +E I L++ +V+ G Sbjct: 15 LGEGAYGEVQLAVNRVTEE--AVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYG 72 Query: 404 VCQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 + + L +E GG L + +P + HQ+ G+ YL HRD+ Sbjct: 73 HRREGNIQYLFLEYCSGGELFDRI-EPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDI 131 Query: 463 AARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFS-SRSD 521 N+LL R KISDFGL+ ++ L + APE + R+F D Sbjct: 132 KPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMC-GTLPYVAPELLKRREFHAEPVD 190 Query: 522 VWSYGVTMWEALSYGQKPYKKMKG--PEVMAFIEQGKRMECPPECPPELYALMSDCWIYK 579 VWS G+ + L+ G+ P+ + E + E+ + + AL+ + Sbjct: 191 VWSCGIVLTAMLA-GELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVEN 249 Query: 580 WEDRPDFLTVEQR 592 R +++ Sbjct: 250 PSARITIPDIKKD 262 >5Z33-A nrPDB Length = 425 Score = 201 bits (512), Expect = 6e-52, Method: Composition-based stats. Identities = 67/330 (20%), Positives = 120/330 (36%), Gaps = 53/330 (16%) Query: 324 ELKDKKLFLKRDNLLIAD------IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEK 377 +L+ +K+F + I D ELG G +G V V + + + KV ++K Sbjct: 13 DLQGRKIFKVFNQDFIVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIK-KVTNVFSKK 71 Query: 378 ADTEEMMREAQIMHQLD-NPYIVRLIG--VCQAEAL---MLVMEMAGGGPLHKFLVGKRE 431 + +RE +++ + I L + + + L E+ L + + Sbjct: 72 ILAKRALREIKLLQHFRGHRNITCLYDMDIPRPDNFNETYLYEELMEC-DLAAIIRS-GQ 129 Query: 432 EIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDS 491 + ++ ++Q+ G+KY+ N +HRDL N+L+ KI DFGL++ D Sbjct: 130 PLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPE 189 Query: 492 YYTARSAGKWPLKWY-APEC-INFRKFSSRSDVWSYGVTMWEALSYGQKPYK-------- 541 +WY APE ++F+ ++ DVWS G + E L G +P+ Sbjct: 190 ENAGYMTEYVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELL--GGRPFFKGRDYVDQ 247 Query: 542 --------KMKGPEVMAFIEQGKRMECPPECP---------------PELYALMSDCWIY 578 E ++ I + E P P+ L+ + Sbjct: 248 LNQILHILGTPNEETLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAF 307 Query: 579 KWEDRPDFLTVEQRMRACYYSLASKVEGPP 608 R VEQ + Y + P Sbjct: 308 DPSSRIS---VEQALEHPYLHIWHDASDEP 334 >3VN9-A nrPDB Length = 340 Score = 201 bits (511), Expect = 7e-52, Method: Composition-based stats. Identities = 73/300 (24%), Positives = 131/300 (43%), Gaps = 24/300 (8%) Query: 327 DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMRE 386 ++ +K D+L +ELG G +G V + R +A+K ++ + + ++ + Sbjct: 43 NQNFEVKADDLEPI-MELGRGAYGVVEKM--RHVPSGQIMAVKRIRATVNSQEQKRLLMD 99 Query: 387 AQI-MHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKF---LVGKREEIPVSNVAEL 441 I M +D P+ V G E + + ME+ L KF ++ K + IP + ++ Sbjct: 100 LDISMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKI 158 Query: 442 LHQVSMGMKYLEEK-NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK 500 + +++L K + +HRD+ NVL+ K+ DFG+S L DS AG Sbjct: 159 AVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLV--DSVAKTIDAGC 216 Query: 501 WPLKWYAPECI----NFRKFSSRSDVWSYGVTMWEALSYGQKPY--KKMKGPEVMAFIEQ 554 P + APE I N + +S +SD+WS G+TM E L+ + PY ++ +E+ Sbjct: 217 KP--YMAPERINPELNQKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTPFQQLKQVVEE 273 Query: 555 GKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKA 614 + E S C ++RP + + M+ +++L S K Sbjct: 274 PSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPEL---MQHPFFTLHESKGTDVASFVKL 330 >3VHK-A nrPDB Length = 368 Score = 201 bits (511), Expect = 8e-52, Method: Composition-based stats. Identities = 68/202 (33%), Positives = 106/202 (52%), Gaps = 8/202 (3%) Query: 403 GVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 G + ++L V E L+K + + + ++ QV+ GM++L + +HRDL Sbjct: 173 GFVEEKSLSDVEEEEAPEDLYK------DFLTLEHLICYSFQVAKGMEFLASRKCIHRDL 226 Query: 463 AARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDV 522 AARN+LL ++ KI DFGL++ + D Y + + PLKW APE I R ++ +SDV Sbjct: 227 AARNILLSEKNVVKICDFGLARDIYK-DPDYVRKGDARLPLKWMAPETIFDRVYTIQSDV 285 Query: 523 WSYGVTMWEALSYGQKPYKKMK-GPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWE 581 WS+GV +WE S G PY +K E +++G RM P PE+Y M DCW + Sbjct: 286 WSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPS 345 Query: 582 DRPDFLTVEQRMRACYYSLASK 603 RP F + + + + A + Sbjct: 346 QRPTFSELVEHLGNLLQANAQQ 367 Score = 102 bits (255), Expect = 4e-22, Method: Composition-based stats. Identities = 38/135 (28%), Positives = 57/135 (42%), Gaps = 13/135 (9%) Query: 305 PRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVY---RMRK 361 P +P+D PY K RD L + LG G FG V + Sbjct: 5 PDELPLDEHCERLPYD------ASKWEFPRDRLKLGK-PLGRGAFGQVIEADAFGIDKTA 57 Query: 362 KQIDVAIKVLKQGTEKADTEEMMREAQIM-HQLDNPYIVRLIGVCQAEA--LMLVMEMAG 418 VA+K+LK+G ++ +M E +I+ H + +V L+G C LM+++E Sbjct: 58 TCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCK 117 Query: 419 GGPLHKFLVGKREEI 433 G L +L KR E Sbjct: 118 FGNLSTYLRSKRNEF 132 >3FME-A nrPDB Length = 290 Score = 201 bits (511), Expect = 8e-52, Method: Composition-based stats. Identities = 70/297 (23%), Positives = 128/297 (43%), Gaps = 24/297 (8%) Query: 330 LFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQI 389 + +K D+L +ELG G +G V + R +A+K ++ + + ++ + I Sbjct: 2 MEVKADDLEPI-MELGRGAYGVVEKM--RHVPSGQIMAVKRIRATVNSQEQKRLLMDLDI 58 Query: 390 -MHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKF---LVGKREEIPVSNVAELLHQ 444 M +D P+ V G E + + ME+ L KF ++ K + IP + ++ Sbjct: 59 SMRTVDCPFTVTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVS 117 Query: 445 VSMGMKYLEEK-NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPL 503 + +++L K + +HRD+ NVL+ K+ DFG+S L D A+ Sbjct: 118 IVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDD----VAKDIDAGCK 173 Query: 504 KWYAPECI----NFRKFSSRSDVWSYGVTMWEALSYGQKPY--KKMKGPEVMAFIEQGKR 557 + APE I N + +S +SD+WS G+TM E L+ + PY ++ +E+ Sbjct: 174 PYMAPERINPELNQKGYSVKSDIWSLGITMIE-LAILRFPYDSWGTPFQQLKQVVEEPSP 232 Query: 558 MECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKA 614 + E S C ++RP + + M+ +++L S K Sbjct: 233 QLPADKFSAEFVDFTSQCLKKNSKERPTYPEL---MQHPFFTLHESKGTDVASFVKL 286 >4BGQ-A nrPDB Length = 304 Score = 201 bits (511), Expect = 8e-52, Method: Composition-based stats. Identities = 52/214 (24%), Positives = 95/214 (44%), Gaps = 10/214 (4%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEM-MREAQIMHQLDNPYIVRLI 402 +G G +G V + ++ + VAIK K E + +E +RE +++ L IV L Sbjct: 20 VGEGAYGVVLKCRHKETHE--IVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELK 77 Query: 403 GVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 + L LV E L + L +P V ++Q+ + + + + VHRD Sbjct: 78 EAFRRRGKLYLVFEYVEKNML-ELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRD 136 Query: 462 LAARNVLLVNRHYAKISDFGLSKALGADDS-YYTARSAGKWPLKWYAPECINFRKFSSRS 520 + N+L+ + K+ DFG ++ L ++ Y A +W + +PE + + Sbjct: 137 IKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRW---YRSPELLLGAPYGKSV 193 Query: 521 DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 554 D+WS G + E LS GQ + + + I++ Sbjct: 194 DMWSVGCILGE-LSDGQPLFPGESEIDQLFTIQK 226 >1CM8-A nrPDB Length = 367 Score = 201 bits (510), Expect = 1e-51, Method: Composition-based stats. Identities = 60/275 (21%), Positives = 112/275 (40%), Gaps = 30/275 (10%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 +G G +G+V V VAIK L + + + RE +++ + + ++ L+ Sbjct: 33 VGSGAYGAVCSAVDGRTG--AKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLL 90 Query: 403 GVCQAEA-------LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK 455 V + LVM G L K + K E++ + L++Q+ G++Y+ Sbjct: 91 DVFTPDETLDDFTDFYLVMPFM-GTDLGKLM--KHEKLGEDRIQFLVYQMLKGLRYIHAA 147 Query: 456 NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFR 514 +HRDL N+ + KI DFGL++ ++ + Y + APE I N+ Sbjct: 148 GIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYV------VTRWYRAPEVILNWM 201 Query: 515 KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPEC-----PPELY 569 +++ D+WS G M E ++ G+ +K + + I + P E E Sbjct: 202 RYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTP-PAEFVQRLQSDEAK 259 Query: 570 ALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKV 604 M + +D F ++ +L K+ Sbjct: 260 NYMKGLPELEKKD---FASILTNASPLAVNLLEKM 291 >5G6V-A nrPDB Length = 324 Score = 201 bits (510), Expect = 1e-51, Method: Composition-based stats. Identities = 54/212 (25%), Positives = 96/212 (45%), Gaps = 9/212 (4%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 +LG G + +V +G ++ VA+K ++ E+ +RE ++ L + IV L Sbjct: 9 KLGEGTYATVYKGKSKLTDN--LVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLH 66 Query: 403 GVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 + E +L LV E L ++L I + NV L Q+ G+ Y + +HRD Sbjct: 67 DIIHTEKSLTLVFEYLDK-DLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRD 125 Query: 462 LAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR-KFSSRS 520 L +N+L+ R K++DFGL++A Y W + P+ + +S++ Sbjct: 126 LKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLW---YRPPDILLGSTDYSTQI 182 Query: 521 DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI 552 D+W G +E + G+ + E + FI Sbjct: 183 DMWGVGCIFYEM-ATGRPLFPGSTVEEQLHFI 213 >4FR4-A nrPDB Length = 384 Score = 200 bits (509), Expect = 1e-51, Method: Composition-based stats. Identities = 62/265 (23%), Positives = 112/265 (42%), Gaps = 13/265 (4%) Query: 327 DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMRE 386 D+ + D+ I +G G+FG V KK + ++ E+ + + +E Sbjct: 7 DENEDVNFDHFEILRA-IGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKE 65 Query: 387 AQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQV 445 QIM L++P++V L Q E + +V+++ GG L L + V + ++ Sbjct: 66 LQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHL-QQNVHFKEETVKLFICEL 124 Query: 446 SMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKW 505 M + YL+ + +HRD+ N+LL + I+DF ++ L + T + + Sbjct: 125 VMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRE----TQITTMAGTKPY 180 Query: 506 YAPECINFRK---FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIE--QGKRMEC 560 APE + RK +S D WS GVT +E L G++PY + + + Sbjct: 181 MAPEMFSSRKGAGYSFAVDWWSLGVTAYELL-RGRRPYHIRSSTSSKEIVHTFETTVVTY 239 Query: 561 PPECPPELYALMSDCWIYKWEDRPD 585 P E+ +L+ + R Sbjct: 240 PSAWSQEMVSLLKKLLEPNPDQRFS 264 >6CTH-A nrPDB Length = 309 Score = 200 bits (509), Expect = 2e-51, Method: Composition-based stats. Identities = 69/293 (23%), Positives = 122/293 (41%), Gaps = 30/293 (10%) Query: 341 DIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVR 400 + +LG G FGSV +G R +A+K + + +++ +E E +I+ +L + +V+ Sbjct: 20 ENKLGEGGFGSVYRGFLRDSDT--YIAVKKVSRASKQG-IKEYASEVKIISRLRHKNLVK 76 Query: 401 LIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN--- 456 LIG C LMLV E G L + + + ++ ++ + YL E+ Sbjct: 77 LIGWCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHEEGDHC 136 Query: 457 FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKF 516 +HRD+ N++L + AK+ DFGL++ + AG + + APEC++ K Sbjct: 137 VLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAG--TVGYMAPECLSSGKA 194 Query: 517 SSRSDVWSYGVTMWEALSYGQK--P--------------YKKMKGPEVMAFIEQGKRMEC 560 S SDV+S+GV E S + P ++ ++ ++ M Sbjct: 195 SKESDVYSFGVVALEIASGRRSIEPKFEESEALLLVPWVWESYGNERILDIADRKLGMAF 254 Query: 561 PPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQK 613 P+ L + C RP V Q + + + PGS Sbjct: 255 DPKQLECLVMVGLWCAHPSHNLRPSIRQVIQVLN-----FEAPLPNLPGSMPI 302 >3FXW-A nrPDB Length = 336 Score = 200 bits (508), Expect = 2e-51, Method: Composition-based stats. Identities = 68/316 (21%), Positives = 127/316 (40%), Gaps = 38/316 (12%) Query: 316 ESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT 375 E + PE K + D+ ++ LG G G V + +R ++ A+K+L Sbjct: 13 EVLFQGPE----PKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKC--ALKLL---- 62 Query: 376 EKADTEEMMREAQIMHQLDN-PYIVRLIGVCQ-----AEALMLVMEMAGGGPLHKFLVGK 429 D+ + +E Q P+IV ++ V + L+++ME GG L + + Sbjct: 63 --YDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQER 120 Query: 430 REE-IPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKA 485 ++ AE++ + +++L N HRD+ N+L + K++DFG +K Sbjct: 121 GDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAK- 179 Query: 486 LGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKG 545 ++ A + + APE + K+ D+WS GV M+ L G P+ G Sbjct: 180 ----ETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GFPPFYSNTG 234 Query: 546 PEVMAFIEQGKRM-----ECPP--ECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYY 598 + +++ R+ P E + L+ +R LT+ Q M + Sbjct: 235 QAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTER---LTITQFMNHPWI 291 Query: 599 SLASKVEGPPGSTQKA 614 + + V P T + Sbjct: 292 NQSMVVPQTPLHTARV 307 >6J5U-C nrPDB Length = 426 Score = 200 bits (508), Expect = 2e-51, Method: Composition-based stats. Identities = 85/375 (22%), Positives = 142/375 (37%), Gaps = 41/375 (10%) Query: 254 CPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTS 313 C +SSA + +P + S + + G + S P P Sbjct: 4 CLDSSAKVDNSNHSPHANSASSGSKVSSKTSRSTGPSGLSTTSYSTDSSFGPLPTLRTEG 63 Query: 314 VYESP----YSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMR-------KK 362 S ELK+ ++DNL LG G FG V +G Sbjct: 64 EILSSPNLKAFTFNELKNATKNFRQDNL------LGEGGFGCVFKGWIDQTSLTASRPGS 117 Query: 363 QIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGP 421 I VA+K LK + +E + E + QL +P +V L+G C + E +LV E G Sbjct: 118 GIVVAVKQLKPEGFQG-HKEWLTEVNYLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGS 176 Query: 422 LHKFLVGKR-EEIPVSNVAELLHQVSMGMKYLEEKN--FVHRDLAARNVLLVNRHYAKIS 478 L L + + + + ++ + G+ +L E ++RD A N+LL AK+S Sbjct: 177 LENHLFRRGAQPLTWAIRMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLS 236 Query: 479 DFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQ- 537 DFGL+KA D+ + + + APE + + +++SDV+S+GV + E +S + Sbjct: 237 DFGLAKAGPTGDNTHVSTKV-IGTHGYAAPEYVATGRLTAKSDVYSFGVVLLELISGRRA 295 Query: 538 ----------------KPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWE 581 PY K ++ ++ + P + L C + Sbjct: 296 MDNSNGGNEYSLVDWATPYLGDK-RKLFRIMDTKLGGQYPQKGAFTAANLALQCLNPDAK 354 Query: 582 DRPDFLTVEQRMRAC 596 RP V + Sbjct: 355 LRPKMSEVLVTLEQL 369 >3ORP-A nrPDB Length = 311 Score = 199 bits (507), Expect = 2e-51, Method: Composition-based stats. Identities = 60/262 (22%), Positives = 108/262 (41%), Gaps = 21/262 (8%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG--TEKADTEEMMREAQIMHQ 392 D + +I LG G V R + DVA+KVL+ + + REAQ Sbjct: 12 DRYELGEI-LGFGGMSEVHLA--RDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAA 68 Query: 393 LDNPYIVRLIGVCQAEAL-----MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSM 447 L++P IV + +AE +VME G L +V + E++ Sbjct: 69 LNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRD-IVHTEGPMTPKRAIEVIADACQ 127 Query: 448 GMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYA 507 + + + +HRD+ N+++ + K+ DFG+++A+ + T +A ++ + Sbjct: 128 ALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLS 187 Query: 508 PECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEV-MAFIEQGKRMECPP---- 562 PE +RSDV+S G ++E L+ G+ P+ V + + PP Sbjct: 188 PEQARGDSVDARSDVYSLGCVLYEVLT-GEPPFTGDSPVSVAYQHVRED---PIPPSARH 243 Query: 563 -ECPPELYALMSDCWIYKWEDR 583 +L A++ E+R Sbjct: 244 EGLSADLDAVVLKALAKNPENR 265 >1V0B-A nrPDB Length = 288 Score = 199 bits (507), Expect = 3e-51, Method: Composition-based stats. Identities = 54/213 (25%), Positives = 93/213 (43%), Gaps = 11/213 (5%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEM-MREAQIMHQLDNPYIVRL 401 ++G G +G V + + A+K ++ E +RE I+ +L + IV+L Sbjct: 9 KIGEGTYGVVYKAQNNYGET---FALKKIRLEKEDEGIPSTTIREISILKELKHSNIVKL 65 Query: 402 IGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 V + L+LV E L K L + L Q+ G+ Y ++ +HR Sbjct: 66 YDVIHTKKRLVLVFEHLDQ-DLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRRVLHR 124 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF-RKFSSR 519 DL +N+L+ KI+DFGL++A G YT W + AP+ + +K+S+ Sbjct: 125 DLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLW---YRAPDVLMGSKKYSTT 181 Query: 520 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI 552 D+WS G E + G + + + + I Sbjct: 182 IDIWSVGCIFAEMV-NGAPLFPGVSEADQLMRI 213 >3HKO-A nrPDB Length = 345 Score = 199 bits (505), Expect = 4e-51, Method: Composition-based stats. Identities = 65/311 (20%), Positives = 111/311 (35%), Gaps = 53/311 (17%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAI--KVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 +G G++G VR + + + I K + D E + E ++M +L +P I RL Sbjct: 34 IGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKLHHPNIARL 93 Query: 402 IGVCQAEA-LMLVMEMAGGGPLHKFL---------------------------------- 426 V + E + LVME+ GG L L Sbjct: 94 YEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECNEEAINGS 153 Query: 427 -VGKREEIP----VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNR--HYAKISD 479 G RE + ++ ++ Q+ + YL + HRD+ N L K+ D Sbjct: 154 IHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKSFEIKLVD 213 Query: 480 FGLSKALGA-DDSYYTARSAGKWPLKWYAPECIN--FRKFSSRSDVWSYGVTMWEALSYG 536 FGLSK ++ Y + + APE +N + + D WS GV + L G Sbjct: 214 FGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVLL-HLLLMG 272 Query: 537 QKPYKKMKGPEVMAFIEQGKRMECPPEC---PPELYALMSDCWIYKWEDRPDFLTVEQRM 593 P+ + + ++ + K P P L+S+ ++R F + Sbjct: 273 AVPFPGVNDADTISQVLNKKLCFENPNYNVLSPLARDLLSNLLNRNVDER--FDAMRALQ 330 Query: 594 RACYYSLASKV 604 + K+ Sbjct: 331 HPWISQFSDKI 341 >4NST-A nrPDB Length = 351 Score = 199 bits (505), Expect = 4e-51, Method: Composition-based stats. Identities = 55/248 (22%), Positives = 102/248 (41%), Gaps = 20/248 (8%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTE-EMMREAQIMHQL 393 D I I +G G +G V + + + VA+K ++ EK +RE +I+ QL Sbjct: 13 DKFDIIGI-IGEGTYGQVYKAKDKDTGE--LVALKKVRLDNEKEGFPITAIREIKILRQL 69 Query: 394 DNPYIVRLIGVCQAEA-----------LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELL 442 + +V + + + LV E L L ++ + Sbjct: 70 IHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDH-DLMGLLESGLVHFSEDHIKSFM 128 Query: 443 HQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWP 502 Q+ G++Y +KNF+HRD+ N+LL N K++DFGL++ +++S + Sbjct: 129 KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEES--RPYTNKVIT 186 Query: 503 LKWYAPECINF-RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECP 561 L + PE + +++ DVWS G + E + + ++ + I + CP Sbjct: 187 LWYRPPELLLGEERYTPAIDVWSCGCILGELFTK-KPIFQANLELAQLELISRLCGSPCP 245 Query: 562 PECPPELY 569 P + Sbjct: 246 AVWPDVIK 253 >4AF3-A nrPDB Length = 292 Score = 199 bits (505), Expect = 4e-51, Method: Composition-based stats. Identities = 71/252 (28%), Positives = 109/252 (43%), Gaps = 14/252 (5%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTE-EMMREAQIMHQ 392 D+ I LG G FG+V R +K VA+KVL K EK E ++ RE +I Sbjct: 23 DDFEIGR-PLGKGKFGNVYLA--REKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAH 79 Query: 393 LDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKY 451 L +P I+RL + L++E A G L+K L K A ++ +++ + Y Sbjct: 80 LHHPNILRLYNYFYDRRRIYLILEYAPRGELYKEL-QKSCTFDEQRTATIMEELADALMY 138 Query: 452 LEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI 511 K +HRD+ N+LL + KI+DFG S + R L + PE I Sbjct: 139 CHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPS-----LRRKTMCGTLDYLPPEMI 193 Query: 512 NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYAL 571 R + + D+W GV +E L G P++ E I + ++ P P L Sbjct: 194 EGRMHNEKVDLWCIGVLCYELL-VGNPPFESASHNETYRRIVKVD-LKFPASVPTGAQDL 251 Query: 572 MSDCWIYKWEDR 583 +S + +R Sbjct: 252 ISKLLRHNPSER 263 >4TNB-A nrPDB Length = 590 Score = 198 bits (504), Expect = 5e-51, Method: Composition-based stats. Identities = 66/310 (21%), Positives = 117/310 (37%), Gaps = 29/310 (9%) Query: 295 EPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKR-------------DNLLIAD 341 E + P K SV+E +P +F R N Sbjct: 130 EEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQY 189 Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVL--KQGTEKADTEEMMREAQIMHQLDNPYIV 399 LG G FG V R K A K L K+ ++ + E QI+ ++++ ++V Sbjct: 190 RVLGKGGFGEVCACQVRATGKM--YACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVV 247 Query: 400 RLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREE-IPVSNVAELLHQVSMGMKYLEEKNF 457 L + +AL LV+ + GG L + ++ G++ L +N Sbjct: 248 NLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHENT 307 Query: 458 VHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFS 517 V+RDL N+LL + + +ISD GL+ + D + + APE +N +++ Sbjct: 308 VYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR----GRVGTVGYMAPEVLNNQRYG 363 Query: 518 SRSDVWSYGVTMWEALSYGQKPYKKMKGP----EVMAFIEQGKRMECPPECPPELYALMS 573 D W G ++E + GQ P++ K EV + + + + + E ++ Sbjct: 364 LSPDYWGLGCLIYEMI-EGQSPFRGRKEKVKREEVDRRVLETEEV-YSHKFSEEAKSICK 421 Query: 574 DCWIYKWEDR 583 + R Sbjct: 422 MLLTKDAKQR 431 >4MYG-A nrPDB Length = 372 Score = 198 bits (503), Expect = 6e-51, Method: Composition-based stats. Identities = 54/241 (22%), Positives = 103/241 (42%), Gaps = 24/241 (9%) Query: 323 EELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE-KADTE 381 +++ L + ++ +G G +GSV + + ++ VAIK L + + + + Sbjct: 32 QDVNKTAWELPKT--YVSPTHVGSGAYGSVCSAIDKRSGEK--VAIKKLSRPFQSEIFAK 87 Query: 382 EMMREAQIMHQLDNPYIVRLIGVCQAEA-------LMLVMEMAGGGPLHKFLVGKREEIP 434 RE ++ + + ++ L+ V + LVM L K + E Sbjct: 88 RAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFM-QTDLQKIM---GMEFS 143 Query: 435 VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYT 494 + L++Q+ G+KY+ VHRDL N+ + KI DFGL++ A+ + Y Sbjct: 144 EEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYV 203 Query: 495 ARSAGKWPLKWYAPECI-NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIE 553 + APE I ++ ++ D+WS G M E L+ G+ +K + + I Sbjct: 204 ------VTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQIL 256 Query: 554 Q 554 + Sbjct: 257 K 257 >2W96-B nrPDB Length = 306 Score = 197 bits (501), Expect = 1e-50, Method: Composition-based stats. Identities = 63/303 (20%), Positives = 111/303 (36%), Gaps = 51/303 (16%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT-EKADTEEMMREAQIMHQLD---NPYI 398 E+G G +G+V + VA+K ++ E+ +RE ++ +L+ +P + Sbjct: 11 EIGVGAYGTVYKARDPHSGH--FVALKSVRVPNGEEGLPISTVREVALLRRLEAFEHPNV 68 Query: 399 VRLIGVCQAE------ALMLVMEMAGGGPLHKFLVGKREEI-PVSNVAELLHQVSMGMKY 451 VRL+ VC + LV E L +L P + +L+ Q G+ + Sbjct: 69 VRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 127 Query: 452 LEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI 511 L VHRDL N+L+ + K++DFGL++ SY A L + APE + Sbjct: 128 LHANCIVHRDLKPENILVTSGGTVKLADFGLARIY----SYQMALDPVVVTLWYRAPEVL 183 Query: 512 NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPEL--- 568 +++ D+WS G E + + + + I + + P ++ Sbjct: 184 LQSTYATPVDMWSVGCIFAEMF-RRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLP 242 Query: 569 -----------------------YALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVE 605 L+ + + R RA +S K E Sbjct: 243 RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKR------ISAFRALQHSYLHKDE 296 Query: 606 GPP 608 G P Sbjct: 297 GNP 299 >4YHJ-A nrPDB Length = 584 Score = 197 bits (501), Expect = 1e-50, Method: Composition-based stats. Identities = 65/323 (20%), Positives = 119/323 (36%), Gaps = 10/323 (3%) Query: 266 AAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEEL 325 AAP P +T + + N E + + R P + S +S + Sbjct: 115 AAPLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQW 174 Query: 326 KDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMR 385 K + N LG G FG V R K K+ ++ + Sbjct: 175 KWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALN 234 Query: 386 EAQIMHQLDNPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREE-IPVSNVAELLH 443 E +I+ ++ + ++V L + +AL LV+ + GG L + Sbjct: 235 EKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAA 294 Query: 444 QVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPL 503 ++ G++ L+ + V+RDL N+LL +R + +ISD GL+ + + Sbjct: 295 ELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVR----GRVGTV 350 Query: 504 KWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM---EC 560 + APE +N K++ D W G ++E + G P+KK K ++Q + E Sbjct: 351 GYMAPEVVNNEKYTFSPDWWGLGCLIYEMI-QGHSPFKKYKEKVKWEEVDQRIKNDTEEY 409 Query: 561 PPECPPELYALMSDCWIYKWEDR 583 + + ++ R Sbjct: 410 SEKFSEDAKSICRMLLTKNPSKR 432 >3OHT-A nrPDB Length = 389 Score = 197 bits (500), Expect = 2e-50, Method: Composition-based stats. Identities = 57/269 (21%), Positives = 111/269 (41%), Gaps = 23/269 (8%) Query: 295 EPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQ 354 E + P S E P +EL + ++ +G G +GSV Sbjct: 12 ESTSLYKKAGSAAAPFTMSHKERPTFYRQELNKTIWEVPERYQTLS--PVGSGAYGSVCS 69 Query: 355 GVYRMRKKQIDVAIKVLKQGTEKA-DTEEMMREAQIMHQLDNPYIVRLIGVC-------Q 406 K + +A+K L + + + RE +++ + + ++ L+ V + Sbjct: 70 SYD--VKSGLKIAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPATSLEE 127 Query: 407 AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARN 466 + LV + G L+ + K +++ +V L++Q+ G+KY+ + +HRDL N Sbjct: 128 FNDVYLVTHLM-GADLNNIV--KCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSN 184 Query: 467 VLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC-INFRKFSSRSDVWSY 525 + + KI DFGL++ + + Y A + APE +N+ ++ D+WS Sbjct: 185 LAVNEDCELKILDFGLARHTDDEMTGYVA------TRWYRAPEIMLNWMHYNMTVDIWSV 238 Query: 526 GVTMWEALSYGQKPYKKMKGPEVMAFIEQ 554 G M E L+ G+ + + I + Sbjct: 239 GCIMAELLT-GRTLFPGTDHINQLQQIMR 266 >3ALO-A nrPDB Length = 327 Score = 197 bits (500), Expect = 2e-50, Method: Composition-based stats. Identities = 67/281 (23%), Positives = 127/281 (45%), Gaps = 23/281 (8%) Query: 326 KDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMR 385 ++ ++L E+G G +GSV + V++ + +A+K ++ ++ + ++++ Sbjct: 13 PEQHWDFTAEDLKDLG-EIGRGAYGSVNKMVHKPSGQ--IMAVKRIRSTVDEKEQKQLLM 69 Query: 386 EAQI-MHQLDNPYIVRLIGVCQAEA-LMLVMEMAGG--GPLHKFLVG-KREEIPVSNVAE 440 + + M D PYIV+ G E + ME+ +K++ + IP + + Sbjct: 70 DLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGK 129 Query: 441 LLHQVSMGMKYLEEK-NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAG 499 + + +L+E +HRD+ N+LL K+ DFG+S L DS R AG Sbjct: 130 ITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLV--DSIAKTRDAG 187 Query: 500 KWPLKWYAPECI----NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP-EVMAFIEQ 554 P + APE I + + + RSDVWS G+T++E L+ G+ PY K + + + + Sbjct: 188 CRP--YMAPERIDPSASRQGYDVRSDVWSLGITLYE-LATGRFPYPKWNSVFDQLTQVVK 244 Query: 555 GKRMECP----PECPPELYALMSDCWIYKWEDRPDFLTVEQ 591 G + E P ++ C RP + + + Sbjct: 245 GDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLK 285 >5LPZ-A nrPDB Length = 332 Score = 196 bits (498), Expect = 3e-50, Method: Composition-based stats. Identities = 67/288 (23%), Positives = 127/288 (44%), Gaps = 29/288 (10%) Query: 332 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMH 391 L+ N D +G G FG V + + + VAIK L + + D E M E + + Sbjct: 13 LQATNGFHNDSLIGSGGFGDVYKAILK---DGSAVAIKKLIHVSGQGDRE-FMAEMETIG 68 Query: 392 QLDNPYIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVGKRE---EIPVSNVAELLHQVSM 447 ++ + +V L+G C+ + +LV E G L L ++ ++ S ++ + Sbjct: 69 KIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSAR 128 Query: 448 GMKYLEEK---NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLK 504 G+ +L + +HRD+ + NVLL A++SDFG+++ + A D++ + + P Sbjct: 129 GLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTP-G 187 Query: 505 WYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY--KKMKGPEVMAFIEQGKRMECPP 562 + PE + S++ DV+SYGV + E L+ G++P ++ +++Q ++ Sbjct: 188 YVPPEYYQSFRCSTKGDVYSYGVVLLELLT-GKRPTDSPDFGDNNLVGWVKQHAKLRISD 246 Query: 563 ECPPEL--------YALMSD------CWIYKWEDRPDFLTVEQRMRAC 596 PEL L+ C + RP + V + Sbjct: 247 VFDPELMKEDPALEIELLQHLKVAVACLDDRAWRRPTMVQVMAMFKEI 294 >5O2B-A nrPDB Length = 285 Score = 196 bits (498), Expect = 3e-50, Method: Composition-based stats. Identities = 56/277 (20%), Positives = 119/277 (42%), Gaps = 24/277 (8%) Query: 336 NLLIADIELGCGNFGSVRQGVYRMRKKQIDVA-IKVLKQGTEKADTEEMMREAQIMHQLD 394 L DIELG G F +V +G+ + ++VA ++ + KA+ + EA+++ L Sbjct: 16 RFLKFDIELGRGAFKTVYKGLD--TETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQ 73 Query: 395 NPYIVRLIGVCQA-----EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGM 449 +P IVR ++ + ++LV E+ G L +L + + + + Q+ G+ Sbjct: 74 HPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYL-KRFKVMKPKVLRSWCRQILKGL 132 Query: 450 KYLEEK--NFVHRDLAARNVLLVN-RHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY 506 ++L + +HRDL N+ + KI D GL+ + + + ++ Sbjct: 133 QFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMR-----TSFAKSVIGTPEFM 187 Query: 507 APECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKG-PEVMAFIEQGKRM-ECPPEC 564 APE + DV+++G+ M E + + PY + + ++ + G + Sbjct: 188 APEMYE-EHYDESVDVYAFGMCMLEMATS-EYPYSECQNAAQIYRKVTSGIKPASFNKVT 245 Query: 565 PPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLA 601 PE+ ++ C +R L++ + +++ Sbjct: 246 DPEVKEIIEGCIRQNKSER---LSIRDLLNHAFFAED 279 >6CCF-A nrPDB Length = 290 Score = 195 bits (497), Expect = 3e-50, Method: Composition-based stats. Identities = 68/287 (23%), Positives = 117/287 (40%), Gaps = 40/287 (13%) Query: 336 NLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKAD---------------- 379 N E+G G +G VR + A+KVL + Sbjct: 5 NQYKLQSEIGKGAYGVVRLAYNESEDRH--YAMKVLSKKKLLKQYGFPRRPPPRGSQAAQ 62 Query: 380 ---------TEEMMREAQIMHQLDNPYIVRLIGVCQA---EALMLVMEMAGGGPLHKFLV 427 E + +E I+ +LD+ +V+LI V + L LV ++ GP+ + V Sbjct: 63 GGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME--V 120 Query: 428 GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALG 487 + L V +G++YL + VHRD+ N+LL + + KI+DFG+S Sbjct: 121 PCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE 180 Query: 488 ADDSYYTARSAGKWPLKWYAPECI--NFRKFSSRS-DVWSYGVTMWEALSYGQKPYKKMK 544 +D+ ++ + + APE I + + FS ++ DVW+ GVT++ YG+ P+ Sbjct: 181 GNDAQLSSTAG---TPAFMAPEAISDSGQSFSGKALDVWATGVTLY-CFVYGKCPFIDDF 236 Query: 545 GPEVMAFIE-QGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVE 590 + I+ + PE EL L+ E R ++ Sbjct: 237 ILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIK 283 >4IC8-A nrPDB Length = 442 Score = 195 bits (497), Expect = 3e-50, Method: Composition-based stats. Identities = 51/237 (21%), Positives = 103/237 (43%), Gaps = 16/237 (6%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEK-ADTEEMMREAQIMHQL 393 D I + +G G +G V R+ +Q VAIK + + + + +RE +I+ Sbjct: 55 DEYEIIET-IGNGAYGVVSSARRRLTGQQ--VAIKKIPNAFDVVTNAKRTLRELKILKHF 111 Query: 394 DNPYIVRLIGVC-------QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVS 446 + I+ + + + +++ +V+++ LH+ + + + + +V L+Q+ Sbjct: 112 KHDNIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIHSS-QPLTLEHVRYFLYQLL 169 Query: 447 MGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY 506 G+KY+ +HRDL N+L+ KI DFG+++ L + + +WY Sbjct: 170 RGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWY 229 Query: 507 -APE-CINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECP 561 APE ++ +++ D+WS G E L+ Q + + I P Sbjct: 230 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQL-FPGKNYVHQLQLIMMVLGTPSP 285 >4U41-A nrPDB Length = 332 Score = 195 bits (497), Expect = 3e-50, Method: Composition-based stats. Identities = 68/277 (24%), Positives = 110/277 (39%), Gaps = 42/277 (15%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL-DNPYIVRLI 402 +G G +G V +G R K AIKV+ + + EE+ E ++ + + I Sbjct: 32 VGNGTYGQVYKG--RHVKTGQLAAIKVM--DVTEDEEEEIKLEINMLKKYSHHRNIATYY 87 Query: 403 GVC-------QAEALMLVMEMAGGGPLHKFLVG-KREEIPVSNVAELLHQVSMGMKYLEE 454 G + L LVME G G + + K + +A + ++ G+ +L Sbjct: 88 GAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHI 147 Query: 455 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR 514 + +HRD+ +NVLL K+ DFG+S L D R+ W APE I Sbjct: 148 HHVIHRDIKGQNVLLTENAEVKLVDFGVSAQL---DRTVGRRNTFIGTPYWMAPEVIACD 204 Query: 515 K-----FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPEL- 568 + + RSD+WS G+T E + G P M + I P PP L Sbjct: 205 ENPDATYDYRSDLWSCGITAIEM-AEGAPPLCDMHPMRALFLI--------PRNPPPRLK 255 Query: 569 --------YALMSDCWIYKWEDRPDFLTVEQRMRACY 597 ++ + C + + RP EQ ++ + Sbjct: 256 SKKWSKKFFSFIEGCLVKNYMQRPS---TEQLLKHPF 289 >5LPV-A nrPDB Length = 296 Score = 195 bits (497), Expect = 4e-50, Method: Composition-based stats. Identities = 67/288 (23%), Positives = 127/288 (44%), Gaps = 29/288 (10%) Query: 332 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMH 391 L+ N D +G G FG V + + + VAIK L + + D E M E + + Sbjct: 13 LQATNGFHNDSLIGSGGFGDVYKAILK---DGSAVAIKKLIHVSGQGDRE-FMAEMETIG 68 Query: 392 QLDNPYIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVGKRE---EIPVSNVAELLHQVSM 447 ++ + +V L+G C+ + +LV E G L L ++ ++ S ++ + Sbjct: 69 KIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSAR 128 Query: 448 GMKYLEEK---NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLK 504 G+ +L + +HRD+ + NVLL A++SDFG+++ + A D++ + + P Sbjct: 129 GLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTP-G 187 Query: 505 WYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY--KKMKGPEVMAFIEQGKRMECPP 562 + PE + S++ DV+SYGV + E L+ G++P ++ +++Q ++ Sbjct: 188 YVPPEYYQSFRCSTKGDVYSYGVVLLELLT-GKRPTDSPDFGDNNLVGWVKQHAKLRISD 246 Query: 563 ECPPEL--------YALMSD------CWIYKWEDRPDFLTVEQRMRAC 596 PEL L+ C + RP + V + Sbjct: 247 VFDPELMKEDPALEIELLQHLKVAVACLDDRAWRRPTMVQVMAMFKEI 294 >3LM0-A nrPDB Length = 327 Score = 195 bits (496), Expect = 4e-50, Method: Composition-based stats. Identities = 65/274 (23%), Positives = 121/274 (44%), Gaps = 19/274 (6%) Query: 323 EELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTE- 381 E L + + + ++ ELG G F VRQ + + ++ A K LK+ D Sbjct: 16 ENLYFQSMENFNNFYILTSKELGRGKFAVVRQCISKSTGQE--YAAKFLKKRRRGQDCRA 73 Query: 382 EMMREAQIMHQLDN-PYIVRLIGVCQ-AEALMLVMEMAGGGPLHKF-LVGKREEIPVSNV 438 E++ E ++ + P ++ L V + ++L++E A GG + L E + ++V Sbjct: 74 EILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDV 133 Query: 439 AELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKALGADDSYYTA 495 L+ Q+ G+ YL + N VH DL +N+LL + KI DFG+S+ +G + Sbjct: 134 IRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIG----HACE 189 Query: 496 RSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG 555 ++ APE +N+ ++ +D+W+ G+ + L++ P+ E I Q Sbjct: 190 LREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTH-TSPFVGEDNQETYLNISQ- 247 Query: 556 KRMECPPECPPELYAL----MSDCWIYKWEDRPD 585 ++ E + L + + E RP Sbjct: 248 VNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPT 281 >4ZSG-A nrPDB Length = 347 Score = 195 bits (496), Expect = 5e-50, Method: Composition-based stats. Identities = 51/237 (21%), Positives = 103/237 (43%), Gaps = 16/237 (6%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEK-ADTEEMMREAQIMHQL 393 D I + +G G +G V R+ +Q VAIK + + + + +RE +I+ Sbjct: 7 DEYEIIET-IGNGAYGVVSSARRRLTGQQ--VAIKKIPNAFDVVTNAKRTLRELKILKHF 63 Query: 394 DNPYIVRLIGVC-------QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVS 446 + I+ + + + +++ +V+++ LH+ + + + + +V L+Q+ Sbjct: 64 KHDNIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIHSS-QPLTLEHVRYFLYQLL 121 Query: 447 MGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY 506 G+KY+ +HRDL N+L+ KI DFG+++ L + + +WY Sbjct: 122 RGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWY 181 Query: 507 -APE-CINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECP 561 APE ++ +++ D+WS G E L+ Q + + I P Sbjct: 182 RAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQL-FPGKNYVHQLQLIMMVLGTPSP 237 >6DTL-A nrPDB Length = 364 Score = 195 bits (496), Expect = 5e-50, Method: Composition-based stats. Identities = 49/221 (22%), Positives = 96/221 (43%), Gaps = 17/221 (7%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVL-KQGTEKADTEEMMREAQIMHQLDNPYIVR 400 + +G G +G V + + VAIK + K D + +RE +++ +D+ IV Sbjct: 36 MPIGKGAYGIVCSAMNSETNES--VAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVA 93 Query: 401 LIGVCQA------EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 454 + + + + E+ LH+ + + + + L+Q+ G+KY+ Sbjct: 94 IRDIIPPPLRNAFNDVYIAYELMD-TDLHQIIRSN-QALSEEHCQYFLYQILRGLKYIHS 151 Query: 455 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPE-CINF 513 N +HRDL N+LL KI DFGL++ + ++ + T +W + APE +N Sbjct: 152 ANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTEYVVTRW---YRAPELLLNS 207 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 554 +++ DVWS G E + + + + + + Sbjct: 208 SDYTAAIDVWSVGCIFMELMDR-KPLFPGRDHVHQLRLLME 247 >4M7I-A nrPDB Length = 299 Score = 195 bits (495), Expect = 5e-50, Method: Composition-based stats. Identities = 62/286 (21%), Positives = 120/286 (41%), Gaps = 39/286 (13%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LG G FG V + ++ + AIK ++ + E++MRE + + +L++P IVR Sbjct: 13 LGRGGFGVVFEAKNKVDD--CNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFN 70 Query: 404 VCQAEA-------------LMLVMEMAGGGPLHKFLVGKR--EEIPVSNVAELLHQVSMG 448 + L + M++ L ++ G+ EE S + Q++ Sbjct: 71 AWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEA 130 Query: 449 MKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYT---------ARSAG 499 +++L K +HRDL N+ K+ DFGL A+ D+ T + Sbjct: 131 VEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQ 190 Query: 500 KWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRME 559 + +PE I+ +S + D++S G+ ++E L P+ E + + + ++ Sbjct: 191 VGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELL----YPFS--TQMERVRTLTDVRNLK 244 Query: 560 CPP----ECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLA 601 PP + P E Y ++ D +RP+ + + + A + L Sbjct: 245 FPPLFTQKYPCE-YVMVQDMLSPSPMERPEAINIIE--NAVFEDLD 287 >2A1A-B nrPDB Length = 284 Score = 194 bits (494), Expect = 7e-50, Method: Composition-based stats. Identities = 68/280 (24%), Positives = 118/280 (42%), Gaps = 36/280 (12%) Query: 333 KRDNLLIADIE-LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMH 391 KR + +IE +G G FG V + +R+ K IK +K EKA+ RE + + Sbjct: 7 KRFGMDFKEIELIGSGGFGQVFKAKHRIDGK--TYVIKRVKYNNEKAE-----REVKALA 59 Query: 392 QLDNPYIVRLIGVC-----------------QAEALMLVMEMAGGGPLHKFLVGKREEI- 433 +LD+ IV G + + L + ME G L +++ +R E Sbjct: 60 KLDHVNIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKL 119 Query: 434 PVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYY 493 EL Q++ G+ Y+ K ++RDL N+ LV+ KI DFGL +L D Sbjct: 120 DKVLALELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDG--- 176 Query: 494 TARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIE 553 R+ K L++ +PE I+ + + D+++ G+ + E L ++ + + Sbjct: 177 -KRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFE---TSKFFTDLR 232 Query: 554 QGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRM 593 G + L+ K EDRP+ + + + Sbjct: 233 DGI---ISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTL 269 >5O2C-A nrPDB Length = 380 Score = 194 bits (494), Expect = 7e-50, Method: Composition-based stats. Identities = 56/277 (20%), Positives = 119/277 (42%), Gaps = 24/277 (8%) Query: 336 NLLIADIELGCGNFGSVRQGVYRMRKKQIDVA-IKVLKQGTEKADTEEMMREAQIMHQLD 394 L DIELG G F +V +G+ + ++VA ++ + KA+ + EA+++ L Sbjct: 25 RFLKFDIELGRGAFKTVYKGLD--TETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQ 82 Query: 395 NPYIVRLIGVCQA-----EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGM 449 +P IVR ++ + ++LV E+ G L +L + + + + Q+ G+ Sbjct: 83 HPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYL-KRFKVMKPKVLRSWCRQILKGL 141 Query: 450 KYLEEK--NFVHRDLAARNVLLVN-RHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY 506 ++L + +HRDL N+ + KI D GL+ + + + ++ Sbjct: 142 QFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMR-----TSFAKSVIGTPEFM 196 Query: 507 APECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKG-PEVMAFIEQGKRM-ECPPEC 564 APE + DV+++G+ M E + + PY + + ++ + G + Sbjct: 197 APEMYE-EHYDESVDVYAFGMCMLEMATS-EYPYSECQNAAQIYRKVTSGIKPASFNKVT 254 Query: 565 PPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLA 601 PE+ ++ C +R L++ + +++ Sbjct: 255 DPEVKEIIEGCIRQNKSER---LSIRDLLNHAFFAED 288 >4PWN-A nrPDB Length = 274 Score = 194 bits (494), Expect = 8e-50, Method: Composition-based stats. Identities = 54/277 (19%), Positives = 123/277 (44%), Gaps = 23/277 (8%) Query: 336 NLLIADIELGCGNFGSVRQGVYRMRKKQIDVA-IKVLKQGTEKADTEEMMREAQIMHQLD 394 L DIE+G G+F +V +G+ + ++VA ++ + K++ + EA+++ L Sbjct: 10 RFLKFDIEIGRGSFKTVYKGLD--TETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQ 67 Query: 395 NPYIVRLIGVCQA-----EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGM 449 +P IVR ++ + ++LV E+ G L +L + + + + + Q+ G+ Sbjct: 68 HPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYL-KRFKVMKIKVLRSWCRQILKGL 126 Query: 450 KYLEEK--NFVHRDLAARNVLLVN-RHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY 506 ++L + +HRDL N+ + KI D GL+ + + + ++ Sbjct: 127 QFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL----EKRASFAKSVIGTPEFM 182 Query: 507 APECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKG-PEVMAFIEQGKRMECPPECP 565 APE K+ DV+++G+ M E + + PY + + ++ + G + + Sbjct: 183 APEMYE-EKYDESVDVYAFGMCMLEMATS-EYPYSECQNAAQIYRRVTSGVKPASFDKVA 240 Query: 566 -PELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLA 601 PE+ ++ C ++R +++ + ++ Sbjct: 241 IPEVKEIIEGCIRQNKDER---YSIKDLLNHAFFQEE 274 >2WTK-C nrPDB Length = 305 Score = 194 bits (493), Expect = 1e-49, Method: Composition-based stats. Identities = 62/254 (24%), Positives = 113/254 (44%), Gaps = 9/254 (3%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTE-EMMREAQIMHQLDNPYIVRLI 402 LG G++G V++ + + V I K+ + E + +E Q++ +L + +++L+ Sbjct: 13 LGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLV 72 Query: 403 GVC---QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 V + + + +VME G + PV Q+ G++YL + VH Sbjct: 73 DVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVH 132 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF-RKFS- 517 +D+ N+LL KIS G+++AL + T R++ P + PE N FS Sbjct: 133 KDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSP-AFQPPEIANGLDTFSG 191 Query: 518 SRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWI 577 + D+WS GVT++ + G P++ ++ I +G P +C P L L+ Sbjct: 192 FKVDIWSAGVTLYNI-TTGLYPFEGDNIYKLFENIGKGSY-AIPGDCGPPLSDLLKGMLE 249 Query: 578 YKWEDRPDFLTVEQ 591 Y+ R + Q Sbjct: 250 YEPAKRFSIRQIRQ 263 >4QNY-A nrPDB Length = 354 Score = 194 bits (492), Expect = 1e-49, Method: Composition-based stats. Identities = 59/303 (19%), Positives = 118/303 (38%), Gaps = 51/303 (16%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG--TEKADTEEMMREAQIMHQ 392 D+ + + +G G++G V + + VA+K + + E + ++RE +++ Sbjct: 19 DDRYLLERIIGAGSYGVVIRARD-TKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAH 77 Query: 393 LDNPYIVRLIGVCQA------EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVS 446 ++ I+ L + + +VM++ L + L +E+ +++ ++Q Sbjct: 78 FNDDNIIGLRNILTPEDPENFDHFYIVMDIME-TDLKQVLRS-GQELTEAHIQFFIYQAL 135 Query: 447 MGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY 506 + + +HRD+ N+L+ KI DFGL+K Y T +W + Sbjct: 136 RALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRW---YR 192 Query: 507 APE-CINFRKFSSRSDVWSYGVTMWEALSYGQKP-YKKMKGPEVMAFIEQ---------- 554 APE + + +S++ DVW G + E L G +P ++ + I Sbjct: 193 APELVMEDKDYSAQIDVWGIGCILGELL--GSRPLFQGKDRVNQLDKIVDVIGTPSEEDI 250 Query: 555 ------------GKRMECP--------PECPPELYALMSDCWIYKWEDRPDFLTVEQRMR 594 K+ P P PE L+ ++ + R +TV Q MR Sbjct: 251 NSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRR---ITVLQAMR 307 Query: 595 ACY 597 + Sbjct: 308 HPF 310 >5AWM-A nrPDB Length = 394 Score = 194 bits (492), Expect = 1e-49, Method: Composition-based stats. Identities = 50/227 (22%), Positives = 90/227 (39%), Gaps = 19/227 (8%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEK-ADTEEMMREAQIMHQLDNPYIVRLI 402 +G G G V Q +VAIK L + + + RE ++M +++ I+ L+ Sbjct: 52 IGSGAQGIVCAAYD--TITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLL 109 Query: 403 GVC-------QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK 455 + + + LVME+ + ++ ++ LL+Q+ G+K+L Sbjct: 110 NAFTPQRNLEEFQDVYLVMELMDANLCQVI----QMDLDHDRMSYLLYQMLCGIKHLHSA 165 Query: 456 NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK 515 +HRDL N+++ KI DFGL++ G + + APE I Sbjct: 166 GIIHRDLKPSNIVVKADCTLKILDFGLARTAG----TTFMMTPYVVTRYYRAPEVILGMG 221 Query: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPP 562 ++ D+WS G M E + G + + I + P Sbjct: 222 YTENVDIWSVGCIMGEMIRGGVL-FPGTDHIDQWNKIIEQLGTPSPS 267 >2XS0-A nrPDB Length = 386 Score = 194 bits (492), Expect = 1e-49, Method: Composition-based stats. Identities = 56/283 (19%), Positives = 107/283 (37%), Gaps = 26/283 (9%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE-KADTEEMMREAQIMHQLDNPYIVR 400 +G G G V + ++ VAIK L + + + + RE +M +++ I+ Sbjct: 32 KPIGSGAQGIVCAAYDAILERN--VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIG 89 Query: 401 LIGVC-------QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 L+ V + + + +VME+ + E+ ++ LL+Q+ G+K+L Sbjct: 90 LLNVFTPQKSLEEFQDVYIVMELMDANLCQVI----QMELDHERMSYLLYQMLCGIKHLH 145 Query: 454 EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF 513 +HRDL N+++ + KI DFGL++ G + APE I Sbjct: 146 SAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS----FMMVPFVVTRYYRAPEVILG 201 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMS 573 + D+WS G M E + G + + + + CP + L Sbjct: 202 MGYKENVDIWSVGCIMGEMIKGGVL-FPGTDHIDQWNKVIEQLGTP----CPEFMKKLQP 256 Query: 574 DCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKAEA 616 Y E+RP + + + + + ++A Sbjct: 257 TVRTYV-ENRPKYAGY--SFEKLFPDVLFPADSEHNKLKASQA 296 >5AR8-A nrPDB Length = 326 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 70/279 (25%), Positives = 129/279 (46%), Gaps = 23/279 (8%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKV--LKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 L G G+V R ++ VA+K + ++ ++++REA+I+H+ YI+ + Sbjct: 40 LSRGASGTVSSA--RHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPI 97 Query: 402 IGVCQAEALM-LVMEMAGGGPLHKFLVGKREEIPVSNVAEL--LHQVSMGMKYLEEK--N 456 +G+C + +V E G L++ L K E V+ LH++++G+ YL Sbjct: 98 LGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPP 157 Query: 457 FVHRDLAARNVLLVNRHYAKISDFGLS--KALGADDSYYTARSAGKWPLKWYAPECI--- 511 +H DL +N+LL N + KI+DFGLS + + S + + + + PE Sbjct: 158 LLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPG 217 Query: 512 NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP-EVMAFIEQGKRM-----ECPPECP 565 + S + D++SY V WE LS ++P++ + P ++M + QG R P + P Sbjct: 218 QKSRASIKHDIYSYAVITWEVLSR-KQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIP 276 Query: 566 --PELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLAS 602 + +L+ W ++RP FL + + Sbjct: 277 HRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEE 315 >3QA8-A nrPDB Length = 676 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 61/214 (28%), Positives = 98/214 (45%), Gaps = 23/214 (10%) Query: 341 DIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVR 400 LG G FG V + +++ +Q VAIK +Q + E E QIM +L++P +V Sbjct: 19 KERLGTGGFGYVLRWIHQDTGEQ--VAIKQCRQELSPKNRERWCLEIQIMKKLNHPNVVS 76 Query: 401 LIGVCQAEAL---------MLVMEMAGGGPLHKFLVGKREEIPVSN--VAELLHQVSMGM 449 V + L +L ME GG L K+L + + LL +S + Sbjct: 77 AREV--PDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSAL 134 Query: 450 KYLEEKNFVHRDLAARNVLLV---NRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY 506 +YL E +HRDL N++L R KI D G +K L + + L++ Sbjct: 135 RYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGE----LCTEFVGTLQYL 190 Query: 507 APECINFRKFSSRSDVWSYGVTMWEALSYGQKPY 540 APE + +K++ D WS+G +E ++ G +P+ Sbjct: 191 APELLEQKKYTVTVDYWSFGTLAFECIT-GFRPF 223 >3OZ6-A nrPDB Length = 388 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 55/237 (23%), Positives = 94/237 (39%), Gaps = 34/237 (14%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD-NPYIVR 400 +LG G +G V + + R + + V K+ D + RE I+ +L + IV Sbjct: 15 KKLGKGAYGIVWKSIDRRTGEVVAVK-KIFDAFQNSTDAQRTFREIMILTELSGHENIVN 73 Query: 401 LIGVCQAEA---LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNF 457 L+ V +A+ + LV + LH + E +++Q+ +KYL Sbjct: 74 LLNVLRADNDRDVYLVFDYME-TDLHAVIRANILEPVHKQ--YVVYQLIKVIKYLHSGGL 130 Query: 458 VHRDLAARNVLLVNRHYAKISDFGLSK---------------------ALGADDSYYTAR 496 +HRD+ N+LL + K++DFGLS+ D T Sbjct: 131 LHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQPILTDY 190 Query: 497 SAGKWPLKWYAPECINFR-KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI 552 A +W + APE + K++ D+WS G + E L G+ + + I Sbjct: 191 VATRW---YRAPEILLGSTKYTKGIDMWSLGCILGEILC-GKPIFPGSSTMNQLERI 243 >3FI2-A nrPDB Length = 353 Score = 192 bits (489), Expect = 3e-49, Method: Composition-based stats. Identities = 55/256 (21%), Positives = 102/256 (39%), Gaps = 24/256 (9%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE-KADTEEMMREAQIMHQLDNPYIVR 400 +G G G V + + VAIK L + + + + RE +M +++ I+ Sbjct: 30 KPIGSGAQGIVCAAYDAVLDRN--VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS 87 Query: 401 LIGVC-------QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 L+ V + + + LVME+ + E+ ++ LL+Q+ G+K+L Sbjct: 88 LLNVFTPQKTLEEFQDVYLVMELMDANLCQVI----QMELDHERMSYLLYQMLCGIKHLH 143 Query: 454 EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF 513 +HRDL N+++ + KI DFGL++ G + + APE I Sbjct: 144 SAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS----FMMTPYVVTRYYRAPEVILG 199 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMS 573 + D+WS G M E + + + + + + + CP + L Sbjct: 200 MGYKENVDIWSVGCIMGEMVRH-KILFPGRDYIDQWNKVIEQLGTP----CPEFMKKLQP 254 Query: 574 DCWIYKWEDRPDFLTV 589 Y E+RP + + Sbjct: 255 TVRNYV-ENRPKYAGL 269 >1JNK-A nrPDB Length = 423 Score = 192 bits (489), Expect = 3e-49, Method: Composition-based stats. Identities = 55/256 (21%), Positives = 102/256 (39%), Gaps = 24/256 (9%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE-KADTEEMMREAQIMHQLDNPYIVR 400 +G G G V + + VAIK L + + + + RE +M +++ I+ Sbjct: 68 KPIGSGAQGIVCAAYDAVLDRN--VAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIS 125 Query: 401 LIGVC-------QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 L+ V + + + LVME+ + E+ ++ LL+Q+ G+K+L Sbjct: 126 LLNVFTPQKTLEEFQDVYLVMELMDANLCQVI----QMELDHERMSYLLYQMLCGIKHLH 181 Query: 454 EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF 513 +HRDL N+++ + KI DFGL++ G + + APE I Sbjct: 182 SAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS----FMMTPYVVTRYYRAPEVILG 237 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMS 573 + D+WS G M E + + + + + + + CP + L Sbjct: 238 MGYKENVDIWSVGCIMGEMVRH-KILFPGRDYIDQWNKVIEQLGTP----CPEFMKKLQP 292 Query: 574 DCWIYKWEDRPDFLTV 589 Y E+RP + + Sbjct: 293 TVRNYV-ENRPKYAGL 307 >4EQM-A nrPDB Length = 294 Score = 192 bits (488), Expect = 4e-49, Method: Composition-based stats. Identities = 61/292 (20%), Positives = 116/292 (39%), Gaps = 17/292 (5%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVL--KQGTEKADTEEMMREAQIMHQ 392 + I D +LG G +V I VAIK + ++ + RE Q Sbjct: 11 ERYKIVD-KLGGGGMSTVYLAED--TILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQ 67 Query: 393 LDNPYIVRLIGV-CQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKY 451 L + IV +I V + + LVME G L +++ + V +Q+ G+K+ Sbjct: 68 LSHQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESH-GPLSVDTAINFTNQILDGIKH 126 Query: 452 LEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI 511 + VHRD+ +N+L+ + KI DFG++KAL T G +++++PE Sbjct: 127 AHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLG--TVQYFSPEQA 184 Query: 512 NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEV-MAFIEQ---GKRMECPPECPPE 567 +D++S G+ ++E L G+ P+ + + I+ + + P Sbjct: 185 KGEATDECTDIYSIGIVLYEML-VGEPPFNGETAVSIAIKHIQDSVPNVTTDVRKDIPQS 243 Query: 568 LYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL-ASKVEGPPGSTQKAEAAC 618 L ++ +R + T+++ L ++ K + Sbjct: 244 LSNVILRATEKDKANR--YKTIQEMKDDLSSVLHENRANEDVYELDKMKTIA 293 >4OTD-A nrPDB Length = 341 Score = 192 bits (487), Expect = 5e-49, Method: Composition-based stats. Identities = 72/263 (27%), Positives = 112/263 (42%), Gaps = 19/263 (7%) Query: 331 FLKRDNLLIADIE----LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMM 384 L++ L + D + LG G+FG V +R + AIK LK+G + + E +M Sbjct: 3 MLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGE--LFAIKALKKGDIVARDEVESLM 60 Query: 385 REAQIMHQLD---NPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAE 440 E +I+ + +P++V L G Q E + VME + GG L + + Sbjct: 61 CEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS--DVFSEPRAIF 118 Query: 441 LLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK 500 V +G+++L E V+RDL N+LL Y KI+DFGL K Y S Sbjct: 119 YSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKE---GMGYGDRTSTFC 175 Query: 501 WPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMEC 560 ++ APE + ++ D W GV ++E L G+ P+ EV I + + Sbjct: 176 GTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEML-VGESPFPGDDEEEVFDSIVNDE-VRY 233 Query: 561 PPECPPELYALMSDCWIYKWEDR 583 P E +M E R Sbjct: 234 PRFLSAEAIGIMRRLLRRNPERR 256 >5O0Y-A nrPDB Length = 579 Score = 191 bits (486), Expect = 6e-49, Method: Composition-based stats. Identities = 71/266 (26%), Positives = 114/266 (42%), Gaps = 26/266 (9%) Query: 349 FGSVRQGVYRMRKKQIDVAI----KVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGV 404 F V + ++ + V I K + ++ + RE +I +LD+P IV+L Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 405 C--QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN--FVHR 460 ++ V+E G L +L + + ++ Q+ +KYL E +H Sbjct: 357 FSLDTDSFCTVLEYCEGNDLDFYLKQHKL-MSEKEARSIIMQIVNALKYLNEIKPPIIHY 415 Query: 461 DLAARNVLLVNR---HYAKISDFGLSKALGADD----SYYTARSAGKWPLKWYAPECI-- 511 DL N+LLVN KI+DFGLSK + D S G + PEC Sbjct: 416 DLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVV 475 Query: 512 --NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAF---IEQGKRMECPPE--C 564 K S++ DVWS GV ++ L YG+KP+ + + + I + ++ PP+ Sbjct: 476 GKEPPKISNKVDVWSVGVIFYQCL-YGRKPFGHNQSQQDILQENTILKATEVQFPPKPVV 534 Query: 565 PPELYALMSDCWIYKWEDRPDFLTVE 590 PE A + C Y+ EDR D + Sbjct: 535 TPEAKAFIRRCLAYRKEDRIDVQQLA 560 >3UIU-A nrPDB Length = 306 Score = 191 bits (485), Expect = 7e-49, Method: Composition-based stats. Identities = 69/300 (23%), Positives = 120/300 (40%), Gaps = 49/300 (16%) Query: 326 KDKKLFLKRDNLLIADIE-LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMM 384 + K KR + +IE +G G FG V + +R+ K I+ +K EKA+ Sbjct: 1 ETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGK--TYVIRRVKYNNEKAE----- 53 Query: 385 REAQIMHQLDNPYIVRLIGVC------------------------------QAEALMLVM 414 RE + + +LD+ IV G + + L + M Sbjct: 54 REVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQM 113 Query: 415 EMAGGGPLHKFLVGKREEI-PVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRH 473 E G L +++ +R E EL Q++ G+ Y+ K +HRDL N+ LV+ Sbjct: 114 EFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTK 173 Query: 474 YAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEAL 533 KI DFGL +L D R+ K L++ +PE I+ + + D+++ G+ + E L Sbjct: 174 QVKIGDFGLVTSLKNDG----KRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL 229 Query: 534 SYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRM 593 ++ + + G + L+ K EDRP+ + + + Sbjct: 230 HVCDTAFE---TSKFFTDLRDGI---ISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTL 283 >3MIA-A nrPDB Length = 351 Score = 190 bits (484), Expect = 1e-48, Method: Composition-based stats. Identities = 54/282 (19%), Positives = 108/282 (38%), Gaps = 43/282 (15%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ++G G FG V + +R +++ + KVL + ++ +RE +I+ L + +V LI Sbjct: 24 KIGQGTFGEVFKARHRKTGQKVALK-KVLMENEKEGFPITALREIKILQLLKHENVVNLI 82 Query: 403 GVCQAE---------ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 +C+ + ++ LV + L L + +S + ++ + G+ Y+ Sbjct: 83 EICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIH 141 Query: 454 EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK-WPLKWYAPECIN 512 +HRD+ A NVL+ K++DFGL++A + R + L + PE + Sbjct: 142 RNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLL 201 Query: 513 F-RKFSSRSDVWSYGVTMWEA---------------------LSYGQKP--YKKMKGPEV 548 R + D+W G M E L P + + E+ Sbjct: 202 GERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYEL 261 Query: 549 MAFIE--QGKRMECPPECPPELY-----ALMSDCWIYKWEDR 583 +E +G++ + + L+ + R Sbjct: 262 YEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQR 303 >5UUU-A nrPDB Length = 547 Score = 190 bits (484), Expect = 1e-48, Method: Composition-based stats. Identities = 57/264 (21%), Positives = 109/264 (41%), Gaps = 19/264 (7%) Query: 329 KLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVL--KQGTEKADTEEMMRE 386 + L ++ + I +G G FG V R A+K L K+ K + E Sbjct: 192 NIHLTMNDFSVHRI-IGRGGFGEVYGC--RKADTGKMYAMKCLDKKRIKMKQGETLALNE 248 Query: 387 AQIMHQL---DNPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELL 442 ++ + D P+IV + + L ++++ GG LH L + +++ Sbjct: 249 RIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL-SQHGVFSEADMRFYA 307 Query: 443 HQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWP 502 ++ +G++++ + V+RDL N+LL + +ISD GL+ + + + G Sbjct: 308 AEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG--- 364 Query: 503 LKWYAPECINFR-KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM--E 559 + APE + + S +D +S G +++ L G P+++ K + M E Sbjct: 365 --YMAPEVLQKGVAYDSSADWFSLGCMLFKLL-RGHSPFRQHKTKDKHEIDRMTLTMAVE 421 Query: 560 CPPECPPELYALMSDCWIYKWEDR 583 P PEL +L+ R Sbjct: 422 LPDSFSPELRSLLEGLLQRDVNRR 445 >5B2L-A nrPDB Length = 324 Score = 190 bits (484), Expect = 1e-48, Method: Composition-based stats. Identities = 63/260 (24%), Positives = 113/260 (43%), Gaps = 19/260 (7%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQI-MHQLDNPYIVRL 401 E+G G G V + +R +A+K +++ K + + ++ + + + D PYIV+ Sbjct: 24 EMGSGTCGQVWKMRFRKTGH--VIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQC 81 Query: 402 IGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYL-EEKNFVH 459 G + + ME+ G K + IP + ++ + + YL E+ +H Sbjct: 82 FGTFITNTDVFIAMELM-GTSAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIH 140 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN-----FR 514 RD+ N+LL R K+ DFG+S L + + + APE I+ Sbjct: 141 RDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCA----AYMAPERIDPPDPTKP 196 Query: 515 KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP-EVMAFIEQGKRMECP--PECPPELYAL 571 + R+DVWS G+++ E L+ GQ PYK K EV+ + Q + P + + Sbjct: 197 DYDIRADVWSLGISLVE-LATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSF 255 Query: 572 MSDCWIYKWEDRPDFLTVEQ 591 + DC RP + + + Sbjct: 256 VKDCLTKDHRKRPKYNKLLE 275 >3GC9-A nrPDB Length = 370 Score = 190 bits (483), Expect = 1e-48, Method: Composition-based stats. Identities = 55/229 (24%), Positives = 99/229 (43%), Gaps = 23/229 (10%) Query: 344 LGCGNFGSVRQGVY-RMRKKQIDVAIKVLKQGTEK-ADTEEMMREAQIMHQLDNPYIVRL 401 +G G +GSV R+R+K VA+K L + + RE +++ L + ++ L Sbjct: 36 VGSGAYGSVCSAYDARLRQK---VAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGL 92 Query: 402 IGVCQA-------EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 454 + V + LV + G L+ + K + + +V L++Q+ G+KY+ Sbjct: 93 LDVFTPATSIEDFSEVYLVTTLM-GADLNNIV--KSQALSDEHVQFLVYQLLRGLKYIHS 149 Query: 455 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC-INF 513 +HRDL NV + +I DFGL++ + + Y A + APE +N+ Sbjct: 150 AGIIHRDLKPSNVAVNEDSELRILDFGLARQADEEMTGYVA------TRWYRAPEIMLNW 203 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPP 562 ++ D+WS G M E L G+ + + + I + P Sbjct: 204 MHYNQTVDIWSVGCIMAELL-QGKALFPGSDYIDQLKRIMEVVGTPSPE 251 >5USZ-A nrPDB Length = 289 Score = 190 bits (483), Expect = 1e-48, Method: Composition-based stats. Identities = 75/279 (26%), Positives = 128/279 (45%), Gaps = 25/279 (8%) Query: 334 RDNLLIADIELGCGNFGSVRQGVYRMRKK-----QIDVAIKVLKQGTEKADTEEMMREAQ 388 R+ LI + LG G F + +GV R + +V +KVL + + +E A Sbjct: 6 RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDK-AHRNYSESFFEAAS 64 Query: 389 IMHQLDNPYIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSM 447 +M +L + ++V GVC + +LV E G L +L + I + E+ Q++ Sbjct: 65 MMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAA 124 Query: 448 GMKYLEEKNFVHRDLAARNVLL--------VNRHYAKISDFGLSKALGADDSYYTARSAG 499 M +LEE +H ++ A+N+LL N + K+SD G+S + D Sbjct: 125 AMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQER---- 180 Query: 500 KWPLKWYAPECI-NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM 558 + W PECI N + + +D WS+G T+WE S G KP + + F E ++ Sbjct: 181 ---IPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQL 237 Query: 559 ECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACY 597 P EL L+++C Y+ + RP F + + + + + Sbjct: 238 PAPK--AAELANLINNCMDYEPDHRPSFRAIIRDLNSLF 274 >4KIK-B nrPDB Length = 677 Score = 190 bits (483), Expect = 2e-48, Method: Composition-based stats. Identities = 57/212 (26%), Positives = 96/212 (45%), Gaps = 19/212 (8%) Query: 341 DIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVR 400 LG G FG+V + + +Q +AIK +Q + E E QIM +L +P +V Sbjct: 24 KERLGTGGFGNVIRWHNQETGEQ--IAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVA 81 Query: 401 LIGVCQ-------AEALMLVMEMAGGGPLHKFLVGKREEIPVSN--VAELLHQVSMGMKY 451 V + + +L ME GG L K+L + + LL ++ ++Y Sbjct: 82 ARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRY 141 Query: 452 LEEKNFVHRDLAARNVLLVNRHY---AKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 L E +HRDL N++L KI D G +K L + ++ L++ AP Sbjct: 142 LHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQG----SLCTSFVGTLQYLAP 197 Query: 509 ECINFRKFSSRSDVWSYGVTMWEALSYGQKPY 540 E + +K++ D WS+G +E ++ G +P+ Sbjct: 198 ELLEQQKYTVTVDYWSFGTLAFECIT-GFRPF 228 >3PVW-A nrPDB Length = 695 Score = 190 bits (483), Expect = 2e-48, Method: Composition-based stats. Identities = 57/264 (21%), Positives = 109/264 (41%), Gaps = 19/264 (7%) Query: 329 KLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVL--KQGTEKADTEEMMRE 386 + L ++ + I +G G FG V R A+K L K+ K + E Sbjct: 183 NIHLTMNDFSVHRI-IGRGGFGEVYGC--RKADTGKMYAMKCLDKKRIKMKQGETLALNE 239 Query: 387 AQIMHQL---DNPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELL 442 ++ + D P+IV + + L ++++ GG LH L + +++ Sbjct: 240 RIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHL-SQHGVFSEADMRFYA 298 Query: 443 HQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWP 502 ++ +G++++ + V+RDL N+LL + +ISD GL+ + + + G Sbjct: 299 AEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG--- 355 Query: 503 LKWYAPECINFR-KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM--E 559 + APE + + S +D +S G +++ L G P+++ K + M E Sbjct: 356 --YMAPEVLQKGVAYDSSADWFSLGCMLFKLL-RGHSPFRQHKTKDKHEIDRMTLTMAVE 412 Query: 560 CPPECPPELYALMSDCWIYKWEDR 583 P PEL +L+ R Sbjct: 413 LPDSFSPELRSLLEGLLQRDVNRR 436 >2HW6-A nrPDB Length = 307 Score = 190 bits (482), Expect = 2e-48, Method: Composition-based stats. Identities = 62/291 (21%), Positives = 110/291 (37%), Gaps = 39/291 (13%) Query: 334 RDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL 393 D + LG G + V+ V K+ A+K++++ + + RE + ++Q Sbjct: 11 EDMYKLTSELLGEGAYAKVQGAVSLQNGKE--YAVKIIEKQAGHS-RSRVFREVETLYQC 67 Query: 394 D-NPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKY 451 N I+ LI + + LV E GG + + K++ + ++ V+ + + Sbjct: 68 QGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHI-QKQKHFNEREASRVVRDVAAALDF 126 Query: 452 LEEKNFVHRDLAARNVLLVNRHY---AKISDFGLSKALGADDSYYTARSAGKWPL----K 504 L K HRDL N+L + KI DF L + ++S + + Sbjct: 127 LHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAE 186 Query: 505 WYAPECI-----NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKG-------------- 545 + APE + + R D+WS GV ++ LS G P+ G Sbjct: 187 YMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLS-GYPPFVGHCGADCGWDRGEVCRVC 245 Query: 546 -PEVMAFIEQGKRMECPP----ECPPELYALMSDCWIYKWEDRPDFLTVEQ 591 ++ I++GK E P E L+S + + R V Q Sbjct: 246 QNKLFESIQEGKY-EFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQ 295 >4BTF-A nrPDB Length = 469 Score = 189 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 54/261 (20%), Positives = 121/261 (46%), Gaps = 14/261 (5%) Query: 356 VYRMRKKQIDVAIKVLKQGTEKAD---TEEMMREAQIMHQLDNPYIVRLIGVC-----QA 407 +YR + V IKV ++ E + M + D+P I+R+ G+C + Sbjct: 211 IYRGEYHRSPVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKP 270 Query: 408 EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNV 467 +VME G L + L + +++ +S + L+ + + G+ L +HR++++ + Sbjct: 271 PEFSIVMEYCELGTLRELL-DREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSF 329 Query: 468 LLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLK-WYAPECIN--FRKFSSRSDVWS 524 L+ + K++ F LSK + + A + + +PE + F + +++++S Sbjct: 330 LVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYS 389 Query: 525 YGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM-ECPPECPPELYALMSDCWIYKWEDR 583 +G+ +WE + G+ P++ ++ + + K+ +CP L ++++C ++ R Sbjct: 390 FGIVLWEI-ATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQR 448 Query: 584 PDFLTVEQRMRACYYSLASKV 604 P + +R+ A S KV Sbjct: 449 PSVDGILERLSAVEESTDKKV 469 >3GC0-A nrPDB Length = 329 Score = 189 bits (481), Expect = 3e-48, Method: Composition-based stats. Identities = 53/226 (23%), Positives = 96/226 (42%), Gaps = 16/226 (7%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTE-EMMREAQIMHQLDNPYIVR 400 +LG G +G V + + + + VAIK ++ E+ +RE ++ +L + I+ Sbjct: 40 TKLGEGTYGEVYKAIDTVTNE--TVAIKRIRLEHEEEGVPGTAIREVSLLKELQHRNIIE 97 Query: 401 LIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 L V L L+ E A L K++ K ++ + + L+Q+ G+ + + +H Sbjct: 98 LKSVIHHNHRLHLIFEYAEN-DLKKYM-DKNPDVSMRVIKSFLYQLINGVNFCHSRRCLH 155 Query: 460 RDLAARNVLL-----VNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF- 513 RDL +N+LL KI DFGL++A G +T W + PE + Sbjct: 156 RDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLW---YRPPEILLGS 212 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRME 559 R +S+ D+WS E L + + + I + + Sbjct: 213 RHYSTSVDIWSIACIWAEMLMK-TPLFPGDSEIDQLFKIFEVLGLP 257 >4M69-B nrPDB Length = 283 Score = 189 bits (480), Expect = 3e-48, Method: Composition-based stats. Identities = 54/261 (20%), Positives = 121/261 (46%), Gaps = 14/261 (5%) Query: 356 VYRMRKKQIDVAIKVLKQGTEKAD---TEEMMREAQIMHQLDNPYIVRLIGVC-----QA 407 +YR + V IKV ++ E + M + D+P I+R+ G+C + Sbjct: 25 IYRGEYHRSPVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKP 84 Query: 408 EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNV 467 +VME G L + L + +++ +S + L+ + + G+ L +HR++++ + Sbjct: 85 PEFSIVMEYCELGTLRELL-DREKDLTMSVRSLLVLRAARGLYRLHHSETLHRNISSSSF 143 Query: 468 LLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLK-WYAPECIN--FRKFSSRSDVWS 524 L+ + K++ F LSK + + A + + +PE + F + +++++S Sbjct: 144 LVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYS 203 Query: 525 YGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM-ECPPECPPELYALMSDCWIYKWEDR 583 +G+ +WE + G+ P++ ++ + + K+ +CP L ++++C ++ R Sbjct: 204 FGIVLWEI-ATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQR 262 Query: 584 PDFLTVEQRMRACYYSLASKV 604 P + +R+ A S KV Sbjct: 263 PSVDGILERLSAVEESTDKKV 283 >2Y4I-B nrPDB Length = 319 Score = 189 bits (480), Expect = 3e-48, Method: Composition-based stats. Identities = 68/299 (22%), Positives = 121/299 (40%), Gaps = 27/299 (9%) Query: 317 SPYSDPEELKDKKLFLKRDNLLIADIELG----CGNFGSVRQGVYRMRKKQIDVAIKVLK 372 S S P + +FL+ ++ +E+G G FG V G + +VAI+++ Sbjct: 10 SARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHG-----EVAIRLID 64 Query: 373 -QGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKR 430 + + + RE Q + +V +G C + L ++ + G L+ + + Sbjct: 65 IERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAK 124 Query: 431 EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGL---SKALG 487 + V+ ++ ++ GM YL K +H+DL ++NV I+DFGL S L Sbjct: 125 IVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQ 183 Query: 488 ADDSYYTARSAGKWPLKWYAPECINF---------RKFSSRSDVWSYGVTMWEALSYGQK 538 A R W L APE I FS SDV++ G +E L + Sbjct: 184 AGRREDKLRIQNGW-LCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYE-LHAREW 241 Query: 539 PYKKMKGPEVMAFIEQGKRMECPP-ECPPELYALMSDCWIYKWEDRPDFLTVEQRMRAC 596 P+K ++ + G + E+ ++ CW ++ E+RP F + + Sbjct: 242 PFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKL 300 >3E7O-A nrPDB Length = 360 Score = 189 bits (480), Expect = 3e-48, Method: Composition-based stats. Identities = 54/264 (20%), Positives = 105/264 (39%), Gaps = 26/264 (9%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE-KADTEEMMREAQIMHQLDNPYIVR 400 +G G G V + I+VA+K L + + + + RE ++ +++ I+ Sbjct: 28 KPIGSGAQGIVCAAFDTVLG--INVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIIS 85 Query: 401 LIGVC-------QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE 453 L+ V + + + LVME+ L + + E+ ++ LL+Q+ G+K+L Sbjct: 86 LLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIH---MELDHERMSYLLYQMLCGIKHLH 141 Query: 454 EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF 513 +HRDL N+++ + KI DFGL++ + + + APE I Sbjct: 142 SAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTN----FMMTPYVVTRYYRAPEVILG 197 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMS 573 + D+WS G M E + G ++ + + + + AL Sbjct: 198 MGYKENVDIWSVGCIMGELV-KGSVIFQGTDHIDQWNKVIEQLGTPS----AEFMAALQP 252 Query: 574 DCWIYKWEDRPDFLTVEQRMRACY 597 Y E+RP + + + Sbjct: 253 TVRNYV-ENRPAYPGIA--FEELF 273 >4CRS-A nrPDB Length = 341 Score = 189 bits (479), Expect = 4e-48, Method: Composition-based stats. Identities = 72/283 (25%), Positives = 112/283 (39%), Gaps = 35/283 (12%) Query: 346 CGNFGSVRQGVYRMRKKQIDVAIKVLKQGT--EKADTEEMMREAQIMH---QLDNPYIVR 400 G+FG V Y+ + AIK LK+G + + + +M E +I + +P++V Sbjct: 22 RGHFGKVLLAEYKNTNEMF--AIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVN 79 Query: 401 LIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 L Q E + VME A GG L + + V +G++YL E V+ Sbjct: 80 LFACFQTKEHVCFVMEYAAGGDLMMHIH--TDVFSEPRAVFYAACVVLGLQYLHEHKIVY 137 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 519 RDL N+LL + KI+DFGL K Y S ++ APE + ++ Sbjct: 138 RDLKLDNLLLDTEGFVKIADFGLCKE---GMGYGDRTSTFCGTPEFLAPEVLTETSYTRA 194 Query: 520 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYK 579 D W GV ++E L G+ P+ EV I + + P E ++M Sbjct: 195 VDWWGLGVLIYEML-VGESPFPGDDEEEVFDSIVNDE-VRYPRFLSTEAISIMRRLLRRN 252 Query: 580 WEDR--------------PDFLTVEQRMRACYYSLASKVEGPP 608 E R P F ++ + +L K PP Sbjct: 253 PERRLGASEKDAEDVKKHPFFRLID------WSALMDKKVKPP 289 >4M66-A nrPDB Length = 325 Score = 187 bits (476), Expect = 9e-48, Method: Composition-based stats. Identities = 75/300 (25%), Positives = 121/300 (40%), Gaps = 32/300 (10%) Query: 334 RDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL 393 R+ L + +G G FG V + +R DVA+K++ ++++ E + M L Sbjct: 19 REELKKLEF-VGKGGFGVVFRAHHRTWNH--DVAVKIVN-------SKKISWEVKAMVNL 68 Query: 394 DNPYIVRLIGVCQA------EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSM 447 N ++ L+GV + LV G L L + P + LL +V + Sbjct: 69 RNENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPR-PWPLLCRLLQEVVL 127 Query: 448 GMKYLEEKN--FVHRDLAARNVLLVNRHYAKISDFGLSK---ALGADDSYYTARSAGKWP 502 GM YL + +HRDL N+LL +AK++DFGLS + + Sbjct: 128 GMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGT 187 Query: 503 LKWYAPECINF--RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRME- 559 L + PE + K S SDV+S+G+ +W L+ + ++ R Sbjct: 188 LAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGREAELVDKTSLIRETVCDRQSRPPL 247 Query: 560 --CPPECP-----PELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQ 612 PP P +L LM CW + E+RP F E + Y + KV+ + Sbjct: 248 TELPPGSPETPGLEKLKELMIHCWGSQSENRPSFQDCEPKTNEVYNLVKDKVDAAVSEVK 307 >5KKR-C nrPDB Length = 395 Score = 187 bits (476), Expect = 1e-47, Method: Composition-based stats. Identities = 76/361 (21%), Positives = 145/361 (40%), Gaps = 56/361 (15%) Query: 274 PSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLK 333 P+ + + + + E K + +D + + + K K LK Sbjct: 8 PTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQ-KQKVGELK 66 Query: 334 RDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL 393 D+ ELG GN G V + ++ + +A K++ + A +++RE Q++H+ Sbjct: 67 DDDFEKIS-ELGAGNGGVVFKVSHKPSG--LVMARKLIHLEIKPAIRNQIIRELQVLHEC 123 Query: 394 DNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYL 452 ++PYIV G ++ + + ME GG L + L K IP + ++ V G+ YL Sbjct: 124 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL-KKAGRIPEQILGKVSIAVIKGLTYL 182 Query: 453 EEKN-FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI 511 EK+ +HRD+ N+L+ +R K+ DFG+S L + ++ + +PE + Sbjct: 183 REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-----SMANSFVGTRSYMSPERL 237 Query: 512 NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEV----------------------- 548 +S +SD+WS G+++ E + G+ P E+ Sbjct: 238 QGTHYSVQSDIWSMGLSLVEM-AVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 296 Query: 549 --MAFIEQGKRMEC-------------PPECPPELYAL-----MSDCWIYKWEDRPDFLT 588 ++ R PP+ P +++L ++ C I +R D Sbjct: 297 RPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQ 356 Query: 589 V 589 + Sbjct: 357 L 357 >2F9G-A nrPDB Length = 353 Score = 187 bits (476), Expect = 1e-47, Method: Composition-based stats. Identities = 57/312 (18%), Positives = 114/312 (36%), Gaps = 54/312 (17%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LG G +G V ++ + VAIK ++ + +RE +I+ + I+ + Sbjct: 19 LGEGAYGVVCSATHKPTGE--IVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFN 76 Query: 404 VCQAEAL------MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNF 457 + + ++ ++ E+ LH+ + + + ++ ++Q +K L N Sbjct: 77 IQRPDSFENFNEVYIIQELM-QTDLHRVI--STQMLSDDHIQYFIYQTLRAVKVLHGSNV 133 Query: 458 VHRDLAARNVLLVNRHYAKISDFGLSKALGA---DDSYYTARSAGKW----PLKWYAPEC 510 +HRDL N+L+ + K+ DFGL++ + D+S T + +G + APE Sbjct: 134 IHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEV 193 Query: 511 -INFRKFSSRSDVWSYGVTMWEALSYGQKPYKK-------------------------MK 544 + K+S DVWS G + E + + ++ Sbjct: 194 MLTSAKYSRAMDVWSCGCILAELFLR-RPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIE 252 Query: 545 GPEVMAFIEQGKRME-------CPPECPPELYALMSDCWIYKWEDRPDFLT-VEQRMRAC 596 P +I+ P P + L+ ++ R +E Sbjct: 253 SPRAREYIKSLPMYPAAPLEKMFPRVNPKGI-DLLQRMLVFDPAKRITAKEALEHPYLQT 311 Query: 597 YYSLASKVEGPP 608 Y+ + EG P Sbjct: 312 YHDPNDEPEGEP 323 >1ZXE-A nrPDB Length = 303 Score = 186 bits (473), Expect = 2e-47, Method: Composition-based stats. Identities = 51/279 (18%), Positives = 100/279 (35%), Gaps = 40/279 (14%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 LG G FG V + R AIK ++ EK T ++ E ++ L++ Y+VR Sbjct: 14 LGQGAFGQVVKA--RNALDSRYYAIKKIRHTEEKLST--ILSEVMLLASLNHQYVVRYYA 69 Query: 404 --------------VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGM 449 V + L + ME L+ + + L Q+ + Sbjct: 70 AWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQILEAL 129 Query: 450 KYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYT-----------ARSA 498 Y+ + +HR+L N+ + KI DFGL+K + ++ Sbjct: 130 SYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSSDNLTS 189 Query: 499 GKWPLKWYAPECINF-RKFSSRSDVWSYGVTMWEALSYGQKPYK-KMKGPEVMAFIEQGK 556 + A E ++ ++ + D++S G+ +E + P+ M+ ++ + Sbjct: 190 AIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI----YPFSTGMERVNILKKLRS-V 244 Query: 557 RMECPPECPPEL----YALMSDCWIYKWEDRPDFLTVEQ 591 +E PP+ ++ + RP T+ Sbjct: 245 SIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLN 283 >5XD6-A nrPDB Length = 305 Score = 186 bits (473), Expect = 2e-47, Method: Composition-based stats. Identities = 72/287 (25%), Positives = 126/287 (43%), Gaps = 35/287 (12%) Query: 340 ADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIV 399 + +G G++G V G+ + AIK L + K +E + + ++ +L +V Sbjct: 26 SKSLIGEGSYGRVFYGILK---SGKAAAIKKL--DSSKQPDQEFLAQVSMVSRLRQENVV 80 Query: 400 RLIGVCQAEAL-MLVMEMAGGGPLHKFLVGKREEI--------PVSNVAELLHQVSMGMK 450 L+G C L +L E A G LH L G++ ++ + G++ Sbjct: 81 ALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAARGLE 140 Query: 451 YLEEK---NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYA 507 YL EK + +HRD+ + NVLL + AKI+DF LS D + + ++A Sbjct: 141 YLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQ-APDMAARLHSTRVLGTFGYHA 199 Query: 508 PECINFRKFSSRSDVWSYGVTMWEALSYGQKPY----------------KKMKGPEVMAF 551 PE S++SDV+S+GV + E L+ G+KP K+ +V Sbjct: 200 PEYAMTGTLSTKSDVYSFGVVLLELLT-GRKPVDHTLPRGQQSVVTWATPKLSEDKVKQC 258 Query: 552 IEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYY 598 ++ E PP+ +L A+ + C Y+ + RP+ V + ++ Sbjct: 259 VDARLNGEYPPKAVAKLAAVAALCVQYEADFRPNMSIVVKALQPLLN 305 >3EQC-A nrPDB Length = 360 Score = 185 bits (471), Expect = 3e-47, Method: Composition-based stats. Identities = 72/309 (23%), Positives = 130/309 (42%), Gaps = 55/309 (17%) Query: 326 KDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMR 385 K K LK D+ ELG GN G V + ++ + +A K++ + A +++R Sbjct: 24 KQKVGELKDDDFEKIS-ELGAGNGGVVFKVSHKPSG--LVMARKLIHLEIKPAIRNQIIR 80 Query: 386 EAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQ 444 E Q++H+ ++PYIV G ++ + + ME GG L + L K IP + ++ Sbjct: 81 ELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL-KKAGRIPEQILGKVSIA 139 Query: 445 VSMGMKYLEEKN-FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPL 503 V G+ YL EK+ +HRD+ N+L+ +R K+ DFG+S L + ++ Sbjct: 140 VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-----SMANSFVGTR 194 Query: 504 KWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEV--------------- 548 + +PE + +S +SD+WS G+++ E + G+ P E+ Sbjct: 195 SYMSPERLQGTHYSVQSDIWSMGLSLVEM-AVGRYPIPPPDAKELELMFGCQVEGDAAET 253 Query: 549 ----------MAFIEQGKRMEC-------------PPECPPELYAL-----MSDCWIYKW 580 + R PP+ P +++L ++ C I Sbjct: 254 PPRPRTPGRPLNKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNP 313 Query: 581 EDRPDFLTV 589 +R D + Sbjct: 314 AERADLKQL 322 >4PL5-B nrPDB Length = 435 Score = 185 bits (470), Expect = 5e-47, Method: Composition-based stats. Identities = 70/307 (22%), Positives = 124/307 (40%), Gaps = 29/307 (9%) Query: 314 VYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGS-VRQGVYRMRKKQIDVAIK-VL 371 + S D E+ + + + + + + D+ LG G G+ V +G++ R VA+K +L Sbjct: 6 EFPSLEQDDEDEETRMVIVGKISFCPKDV-LGHGAEGTIVYKGMFDNRD----VAVKRIL 60 Query: 372 KQGTEKADTEEMMREAQIMHQLD-NPYIVRLIGVCQAEAL-MLVMEMAGGGPLHKFLVGK 429 + AD RE Q++ + D +P ++R + + +E+ L +++ K Sbjct: 61 PECFSFAD-----REVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-TLQEYVEQK 114 Query: 430 REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLL---VNRHYAK--ISDFGLSK 484 LLHQ + G+ +L N VHRDL N+LL K ISDFGL K Sbjct: 115 DFAHLGLEPITLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCK 174 Query: 485 ALGADDSYYTARSAGKWPLKWYAPECIN---FRKFSSRSDVWSYGVTMWEALSYGQKPYK 541 L ++ RS W APE ++ + D++S G + +S G P+ Sbjct: 175 KLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPF- 233 Query: 542 KMKGPEVMAFIEQGKRMECPPECPPE---LYALMSDCWIYKWEDRPDFLTVEQRMRACYY 598 + ++C E L+ + RP V + ++ Sbjct: 234 GKSLQRQANILLGACNLDCFHSDKHEDVIARELIEKMIAMDPQQRPSAKHVLK--HPFFW 291 Query: 599 SLASKVE 605 SL +++ Sbjct: 292 SLEKQLQ 298 >3DLS-A nrPDB Length = 335 Score = 184 bits (468), Expect = 8e-47, Method: Composition-based stats. Identities = 55/255 (21%), Positives = 109/255 (42%), Gaps = 21/255 (8%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEE-----MMREAQIMHQLDNPYI 398 LG G FG V V + + K++ V ++ E E+ + E I+ ++++ I Sbjct: 32 LGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANI 91 Query: 399 VRLIGVCQAEALM-LVMEMAGGG-PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 ++++ + + + LVME G G L F+ + + + + Q+ + YL K+ Sbjct: 92 IKVLDIFENQGFFQLVMEKHGSGLDLFAFI-DRHPRLDEPLASYIFRQLVSAVGYLRLKD 150 Query: 457 FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKF 516 +HRD+ N+++ K+ DFG + L +YT +++ APE + + Sbjct: 151 IIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFC----GTIEYCAPEVLMGNPY 206 Query: 517 -SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDC 575 ++WS GVT++ + + P+ E+ +E + P EL +L+S Sbjct: 207 RGPELEMWSLGVTLYTLVFE-ENPFC-----ELEETVEAA--IHPPYLVSKELMSLVSGL 258 Query: 576 WIYKWEDRPDFLTVE 590 E R + Sbjct: 259 LQPVPERRTTLEKLV 273 >3UIM-A nrPDB Length = 326 Score = 184 bits (467), Expect = 1e-46, Method: Composition-based stats. Identities = 67/297 (22%), Positives = 122/297 (41%), Gaps = 32/297 (10%) Query: 323 EELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEE 382 + ++L + DN +I LG G FG V +G VA+K LK+ + + Sbjct: 18 KRFSLRELQVASDNFSNKNI-LGRGGFGKVYKGRL---ADGTLVAVKRLKEERTQGGELQ 73 Query: 383 MMREAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIP---VSNV 438 E +++ + ++RL G C +LV G + L + E P Sbjct: 74 FQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKR 133 Query: 439 AELLHQVSMGMKYLEEK---NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTA 495 + + G+ YL + +HRD+ A N+LL A + DFGL+K + D++ T Sbjct: 134 QRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVT- 192 Query: 496 RSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYK-------------- 541 +A + + APE ++ K S ++DV+ YGV + E ++ GQ+ + Sbjct: 193 -TAVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELIT-GQRAFDLARLANDDDVMLLD 250 Query: 542 ----KMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMR 594 +K ++ A ++ + E +L + C +RP V + + Sbjct: 251 WVKGLLKEKKLEALVDVDLQGNYKDEEVEQLIQVALLCTQSSPMERPKMSEVVRMLE 307 >5TQX-A nrPDB Length = 655 Score = 183 bits (465), Expect = 2e-46, Method: Composition-based stats. Identities = 55/208 (26%), Positives = 96/208 (46%), Gaps = 18/208 (8%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL-- 401 LG G FG+V +Y+ R+ + +AIK + + E E QIM +L++ +V+ Sbjct: 16 LGTGGFGNV--CLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVVKACD 73 Query: 402 ----IGVCQAEALMLVMEMAGGGPLHKFLVGKREEI--PVSNVAELLHQVSMGMKYLEEK 455 + + + +L ME GG L K L S + LL + G++YL E Sbjct: 74 VPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHEN 133 Query: 456 NFVHRDLAARNVLL-VNRHYA--KISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN 512 +HRDL N++L KI D G +K + + + L++ APE Sbjct: 134 KIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGE----LCTEFVGTLQYLAPELFE 189 Query: 513 FRKFSSRSDVWSYGVTMWEALSYGQKPY 540 + +++ D WS+G ++E ++ G +P+ Sbjct: 190 NKPYTATVDYWSFGTMVFECIA-GYRPF 216 >1S9I-A nrPDB Length = 354 Score = 183 bits (465), Expect = 2e-46, Method: Composition-based stats. Identities = 77/313 (24%), Positives = 134/313 (42%), Gaps = 59/313 (18%) Query: 326 KDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMR 385 K K LK D+ ELG GN G V + +R + +A K++ + A +++R Sbjct: 7 KAKVGELKDDDFERIS-ELGAGNGGVVTKVQHRPSG--LIMARKLIHLEIKPAIRNQIIR 63 Query: 386 EAQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQ 444 E Q++H+ ++PYIV G ++ + + ME GG L + L + + IP + ++ Sbjct: 64 ELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL-KEAKRIPEEILGKVSIA 122 Query: 445 VSMGMKYLEEKN-FVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPL 503 V G+ YL EK+ +HRD+ N+L+ +R K+ DFG+S L + ++ Sbjct: 123 VLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-----SMANSFVGTR 177 Query: 504 KWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI-------EQGK 556 + APE + +S +SD+WS G+++ E L+ G+ P E+ A E+G+ Sbjct: 178 SYMAPERLQGTHYSVQSDIWSMGLSLVE-LAVGRYPIPPPDAKELEAIFGRPVVDGEEGE 236 Query: 557 RM-----------------------------------ECPPECP-----PELYALMSDCW 576 E PP+ P P+ ++ C Sbjct: 237 PHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCL 296 Query: 577 IYKWEDRPDFLTV 589 I +R D + Sbjct: 297 IKNPAERADLKML 309 >4RT7-A nrPDB Length = 415 Score = 183 bits (464), Expect = 2e-46, Method: Composition-based stats. Identities = 59/161 (36%), Positives = 88/161 (54%), Gaps = 2/161 (1%) Query: 434 PVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYY 493 ++ +QV+ GM++LE K+ VHRDLAARNVL+ + KI DFGL++ + DS Y Sbjct: 241 TFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDI-MSDSNY 299 Query: 494 TARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMK-GPEVMAFI 552 R + P+KW APE + ++ +SDVWSYG+ +WE S G PY + I Sbjct: 300 VVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLI 359 Query: 553 EQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRM 593 + G +M+ P E+Y +M CW + RP F + + Sbjct: 360 QNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 400 Score = 111 bits (277), Expect = 1e-24, Method: Composition-based stats. Identities = 40/124 (32%), Positives = 59/124 (47%), Gaps = 7/124 (5%) Query: 316 ESPYSDPEELK-DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRM---RKKQIDVAIKVL 371 E Y D E + D K R+NL + LG G FG V I VA+K+L Sbjct: 45 EYFYVDFREYEYDLKWEFPRENLEFGKV-LGSGAFGKVMNATAYGISKTGVSIQVAVKML 103 Query: 372 KQGTEKADTEEMMREAQIMHQL-DNPYIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVGK 429 K+ + ++ E +M E ++M QL + IV L+G C + + L+ E G L +L K Sbjct: 104 KEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSK 163 Query: 430 REEI 433 RE+ Sbjct: 164 REKF 167 >2QKW-B nrPDB Length = 321 Score = 183 bits (464), Expect = 2e-46, Method: Composition-based stats. Identities = 65/278 (23%), Positives = 110/278 (39%), Gaps = 24/278 (8%) Query: 336 NLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN 395 N +G G FG V +GV R VA+K + EE E + + + Sbjct: 39 NNFDHKFLIGHGVFGKVYKGVLR---DGAKVALKR-RTPESSQGIEEFETEIETLSFCRH 94 Query: 396 PYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKR---EEIPVSNVAELLHQVSMGMKY 451 P++V LIG C + ++L+ + G L + L G + E+ + G+ Y Sbjct: 95 PHLVSLIGFCDERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHY 154 Query: 452 LEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI 511 L + +HRD+ + N+LL KI+DFG+SK D + + K L + PE Sbjct: 155 LHTRAIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVV-KGTLGYIDPEYF 213 Query: 512 NFRKFSSRSDVWSYGVTMWEALSYG-----QKPY----------KKMKGPEVMAFIEQGK 556 + + +SDV+S+GV ++E L P + ++ ++ Sbjct: 214 IKGRLTEKSDVYSFGVVLFEVLCARSAIVQSLPREMVNLAEWAVESHNNGQLEQIVDPNL 273 Query: 557 RMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMR 594 + PE + C EDRP V ++ Sbjct: 274 ADKIRPESLRKFGDTAVKCLALSSEDRPSMGDVLWKLE 311 >2I6L-A nrPDB Length = 320 Score = 182 bits (462), Expect = 4e-46, Method: Composition-based stats. Identities = 53/230 (23%), Positives = 96/230 (41%), Gaps = 24/230 (10%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 LGCG G V V K+ VAIK + T+ + +RE +I+ +LD+ IV++ Sbjct: 17 KPLGCGGNGLVFSAVDNDCDKR--VAIKKI-VLTDPQSVKHALREIKIIRRLDHDNIVKV 73 Query: 402 IGVC---------------QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVS 446 + + ++ +V E L L ++ + + ++Q+ Sbjct: 74 FEILGPSGSQLTDDVGSLTELNSVYIVQEYME-TDLANVL--EQGPLLEEHARLFMYQLL 130 Query: 447 MGMKYLEEKNFVHRDLAARNVLLV-NRHYAKISDFGLSKALGADDSYYTARSAGKWPLKW 505 G+KY+ N +HRDL N+ + KI DFGL++ + S+ S G + Sbjct: 131 RGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWY 190 Query: 506 YAPECINF-RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 554 +P + ++ D+W+ G E L+ G+ + E M I + Sbjct: 191 RSPRLLLSPNNYTKAIDMWAAGCIFAEMLT-GKTLFAGAHELEQMQLILE 239 >3N9X-A nrPDB Length = 432 Score = 182 bits (461), Expect = 5e-46, Method: Composition-based stats. Identities = 52/226 (23%), Positives = 99/226 (43%), Gaps = 32/226 (14%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEK-ADTEEMMREAQIMHQL 393 DN +I + +G G++G V + +K VAIK + + E D + ++RE I+++L Sbjct: 26 DNYIIKHL-IGRGSYGYVYLAYDKNTEKN--VAIKKVNRMFEDLIDCKRILREITILNRL 82 Query: 394 DNPYIVRLIGVC------QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSM 447 + YI+RL + + + L +V+E+A L K + ++ +L+ + + Sbjct: 83 KSDYIIRLYDLIIPDDLLKFDELYIVLEIAD-SDLKKLFKTPIF-LTEEHIKTILYNLLL 140 Query: 448 GMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD------------------ 489 G ++ E +HRDL N LL K+ DFGL++ + ++ Sbjct: 141 GENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPH 200 Query: 490 -DSYYTARSAGKWPLKWYAPE-CINFRKFSSRSDVWSYGVTMWEAL 533 + ++ + APE + ++ D+WS G E L Sbjct: 201 NKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELL 246 >4IDT-A nrPDB Length = 356 Score = 181 bits (459), Expect = 8e-46, Method: Composition-based stats. Identities = 72/305 (23%), Positives = 115/305 (37%), Gaps = 24/305 (7%) Query: 299 ITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIAD--------IELGCGNFG 350 +TS K S SP ++ E LK + + + LG G+FG Sbjct: 29 LTSLAKTWAARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFG 88 Query: 351 SVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG-VCQAEA 409 V + + A+K ++ +A+ E L +P IV L G V + Sbjct: 89 EVHRMEDKQTG--FQCAVKKVRLEVFRAE------ELMACAGLTSPRIVPLYGAVREGPW 140 Query: 410 LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLL 469 + + ME+ GG L + LV ++ +P L Q G++YL + +H D+ A NVLL Sbjct: 141 VNIFMELLEGGSLGQ-LVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLL 199 Query: 470 VNRH-YAKISDFGLSKALGADDSYYTARSAGKWP--LKWYAPECINFRKFSSRSDVWSYG 526 + +A + DFG + L D + P APE + R ++ DVWS Sbjct: 200 SSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSC 259 Query: 527 VTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM--ECPPECPPELYALMSDCWIYKWEDRP 584 M L G P+ + + I E PP C P + + + R Sbjct: 260 CMMLHML-NGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRV 318 Query: 585 DFLTV 589 + Sbjct: 319 SAAEL 323 >3NIE-A nrPDB Length = 429 Score = 181 bits (459), Expect = 9e-46, Method: Composition-based stats. Identities = 56/229 (24%), Positives = 99/229 (43%), Gaps = 35/229 (15%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEK-ADTEEMMREAQIMHQL 393 DN I + +G G++G V + K VAIK + + E D + ++RE I+++L Sbjct: 28 DNYEIKHL-IGRGSYGYVYLAYDKNANKN--VAIKKVNRMFEDLIDCKRILREITILNRL 84 Query: 394 DNPYIVRLIGVC------QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSM 447 + YI+RL + + + L +V+E+A L K + +V +L+ + + Sbjct: 85 KSDYIIRLHDLIIPEDLLKFDELYIVLEIAD-SDLKKLFKTPIF-LTEQHVKTILYNLLL 142 Query: 448 GMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYY-------------- 493 G K++ E +HRDL N LL KI DFGL++ + +D + Sbjct: 143 GEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEP 202 Query: 494 --------TARSAGKWPLKWYAPE-CINFRKFSSRSDVWSYGVTMWEAL 533 ++ + APE + +++ D+WS G E L Sbjct: 203 GPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELL 251 >4X7Q-B nrPDB Length = 312 Score = 181 bits (459), Expect = 9e-46, Method: Composition-based stats. Identities = 65/278 (23%), Positives = 119/278 (42%), Gaps = 31/278 (11%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG-----TEKADTEEMMREAQIMHQLD---- 394 LG G FG+V G +R+ + + VAIKV+ + + +D+ E ++ ++ Sbjct: 39 LGKGGFGTVFAG-HRLTDR-LQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGG 96 Query: 395 NPYIVRLIGVCQA-EALMLVMEM-AGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYL 452 +P ++RL+ + E MLV+E L ++ K + QV +++ Sbjct: 97 HPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEK-GPLGEGPSRCFFGQVVAAIQHC 155 Query: 453 EEKNFVHRDLAARNVLLV-NRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI 511 + VHRD+ N+L+ R AK+ DFG S AL D+ Y + PE I Sbjct: 156 HSRGVVHRDIKDENILIDLRRGCAKLIDFG-SGALLHDEPYTDF----DGTRVYSPPEWI 210 Query: 512 NFRKFSS-RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYA 570 + ++ + + VWS G+ +++ + G P++ + E++ + P P+ A Sbjct: 211 SRHQYHALPATVWSLGILLYDMVC-GDIPFE--RDQEILEA-----ELHFPAHVSPDCCA 262 Query: 571 LMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPP 608 L+ C K RP + + + A V P Sbjct: 263 LIRRCLAPKPSSRPSLEEI--LLDPWMQTPAEDVPLNP 298 >2BUJ-A nrPDB Length = 317 Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 63/293 (21%), Positives = 116/293 (39%), Gaps = 28/293 (9%) Query: 325 LKDKKLFLKRDNLLIADIELGCGNFGSV--RQGVYRMRKKQIDVAIKVLKQGTEKADTEE 382 + + + + L +LG G F V +G++ A+K + E+ D EE Sbjct: 19 FQGHMVIIDNKHYLFI-QKLGEGGFSYVDLVEGLH----DGHFYALKRI-LCHEQQDREE 72 Query: 383 MMREAQIMHQLDNPYIVRLIGVCQAE-----ALMLVMEMAGGGPLH---KFLVGKREEIP 434 REA + ++P I+RL+ C E L++ G L + L K + Sbjct: 73 AQREADMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLT 132 Query: 435 VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGL----SKALGADD 490 + LL + G++ + K + HRDL N+LL + + D G + Sbjct: 133 EDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSR 192 Query: 491 SYYTAR--SAGKWPLKWYAPECINFRKF---SSRSDVWSYGVTMWEALSYGQKPYKKM-- 543 T + +A + + + APE + + R+DVWS G ++ + +G+ PY + Sbjct: 193 QALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMM-FGEGPYDMVFQ 251 Query: 544 KGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRAC 596 KG V ++ + P L+ L++ RP + ++ A Sbjct: 252 KGDSVALAVQNQLSIPQSPRHSSALWQLLNSMMTVDPHQRPHIPLLLSQLEAL 304 >4MWI-A nrPDB Length = 294 Score = 179 bits (455), Expect = 3e-45, Method: Composition-based stats. Identities = 50/255 (19%), Positives = 114/255 (44%), Gaps = 16/255 (6%) Query: 356 VYRMRKKQIDVAIKVLKQ---GTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA--- 409 +Y+ + VAIKV K+ G+ + +E + M + ++P I+R+ G+C E Sbjct: 40 LYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTP 99 Query: 410 --LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE--EKNFVHRDLAAR 465 +VME G L + L + +++ + L+ + G+ L E +H + + Sbjct: 100 PQFSIVMEYCELGTLRELL-DREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSS 158 Query: 466 NVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKW-PLKWYAPECIN--FRKFSSRSDV 522 N L+ + K++ F L K + T + + +P+ + F ++ +S++ Sbjct: 159 NFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEI 218 Query: 523 WSYGVTMWEALSYGQKPYKKMKGPEVMAFIE-QGKRMECPPECPPELYALMSDCWIYKWE 581 +S+G+ +WE + G P++ ++ + + ++ +CP EL ++ +C + Sbjct: 219 YSFGIVLWEI-ATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPS 277 Query: 582 DRPDFLTVEQRMRAC 596 RP + +++ Sbjct: 278 VRPSVDEILKKLSTF 292 >6CKI-A nrPDB Length = 316 Score = 179 bits (455), Expect = 3e-45, Method: Composition-based stats. Identities = 57/291 (19%), Positives = 109/291 (37%), Gaps = 39/291 (13%) Query: 334 RDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL 393 D + + LG G V+ + + ++ A+K++++ + RE ++++Q Sbjct: 11 EDVYQLQEDVLGEGAHARVQTCINLITSQE--YAVKIIEKQPGHI-RSRVFREVEMLYQC 67 Query: 394 D-NPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKY 451 + ++ LI + + LV E GG + + +R + ++ V+ + + Sbjct: 68 QGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRH-FNELEASVVVQDVASALDF 126 Query: 452 LEEKNFVHRDLAARNVLLVNRHY---AKISDFGLSKALGADDSYYTARS----AGKWPLK 504 L K HRDL N+L + + KI DFGL + + + + Sbjct: 127 LHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAE 186 Query: 505 WYAPECI-----NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPE------------ 547 + APE + + R D+WS GV ++ LS G P+ G + Sbjct: 187 YMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLS-GYPPFVGRCGSDCGWDRGEACPAC 245 Query: 548 ---VMAFIEQGKRMECPP----ECPPELYALMSDCWIYKWEDRPDFLTVEQ 591 + I++GK E P L+S + + R V Q Sbjct: 246 QNMLFESIQEGKY-EFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQ 295 >3RP9-A nrPDB Length = 458 Score = 179 bits (454), Expect = 3e-45, Method: Composition-based stats. Identities = 47/239 (19%), Positives = 99/239 (41%), Gaps = 36/239 (15%) Query: 326 KDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMR 385 + D I + +G G++G V + ++ K+ + + K+L+ + D + ++R Sbjct: 45 PHSDWQIP-DRYEIRHL-IGTGSYGHVCEAYDKLEKRVVAIK-KILRVFEDLIDCKRILR 101 Query: 386 EAQIMHQLDNPYIVRLIGVC------QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVA 439 E I+++L++ ++V+++ + + + L +V+E+A K L + ++ Sbjct: 102 EIAILNRLNHDHVVKVLDIVIPKDVEKFDELYVVLEIADSD--FKKLFRTPVYLTELHIK 159 Query: 440 ELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSK--------------- 484 LL+ + +G+KY+ +HRDL N L+ K+ DFGL++ Sbjct: 160 TLLYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPIS 219 Query: 485 ---------ALGADDSYYTARSAGKWPLKWYAPE-CINFRKFSSRSDVWSYGVTMWEAL 533 + + + APE + ++ DVWS G E L Sbjct: 220 PREDDMNLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELL 278 >4O2Z-A nrPDB Length = 377 Score = 179 bits (453), Expect = 5e-45, Method: Composition-based stats. Identities = 56/284 (19%), Positives = 101/284 (35%), Gaps = 46/284 (16%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL-- 401 LG G +G + +++ + K + D + ++RE +M + ++ + Sbjct: 53 LGMGAYGIACSCLDGDTGEKVSIK-KCRDVFRDVEDGKRVLREIDMMRFFHHENLLNVVN 111 Query: 402 ------IGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK 455 E + +V + ++ R+ + S++ ++Q+ G+KYL Sbjct: 112 ILPPLKREYHSFEDVYVVTPLMDVD--MNVVLRSRQVLEESHMQYFVYQILRGLKYLHSA 169 Query: 456 NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR- 514 N HRDL N++ KI DFGLS+++ S T +W + PE + Sbjct: 170 NVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRW---YRPPELLLENT 226 Query: 515 KFSSRSDVWSYGVTMWEALSYGQKP-YKKMKGPEVMAFIEQ--GKRMECPPECPPELYAL 571 +S+ D+WS G E Y +KP + + + I Q GK E L L Sbjct: 227 NYSTAVDIWSVGCIFAEM--YNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEHREALEKL 284 Query: 572 --------------------------MSDCWIYKWEDRPDFLTV 589 +S W RP + Sbjct: 285 NELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAADM 328 >1TKI-A nrPDB Length = 321 Score = 178 bits (452), Expect = 5e-45, Method: Composition-based stats. Identities = 58/271 (21%), Positives = 112/271 (41%), Gaps = 22/271 (8%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVA-IKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 +LG G FG V + V KK +KV + D + +E I++ + I+ L Sbjct: 12 DLGRGEFGIVHRCVETSSKKTYMAKFVKV-----KGTDQVLVKKEISILNIARHRNILHL 66 Query: 402 IGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 ++ E L+++ E G + + + E+ + +HQV +++L N H Sbjct: 67 HESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIGHF 126 Query: 461 DLAARNVLLVNR--HYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSS 518 D+ N++ R KI +FG ++ L D++ +A ++YAPE S+ Sbjct: 127 DIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTA----PEYYAPEVHQHDVVST 182 Query: 519 RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM---ECPPECPPELYALMSDC 575 +D+WS G ++ LS G P+ +++ I + E E E + Sbjct: 183 ATDMWSLGTLVYVLLS-GINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRL 241 Query: 576 WIYKWEDRPDFLTVEQRMRACYYSLASKVEG 606 + + + R + ++ + L K+E Sbjct: 242 LVKERKSRMTAS---EALQHPW--LKQKIER 267 >4OW8-A nrPDB Length = 283 Score = 178 bits (452), Expect = 5e-45, Method: Composition-based stats. Identities = 64/248 (25%), Positives = 108/248 (43%), Gaps = 14/248 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG--TEKADTEEMMREAQIMHQLDNPYIVRL 401 + G G V + V ++ VA+KVLK ++ E EA+ L++P I + Sbjct: 19 IATGGMGQVWEAVDNRLGRR--VAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASV 76 Query: 402 IGVCQAE------ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK 455 +++ LVME+ G PL+ L + + + + ++L Q ++ Sbjct: 77 HDYGESQMNGEGRTAYLVMELVNGEPLNSVL-KRTGRLSLRHALDMLEQTGRALQIAHAA 135 Query: 456 NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK 515 VHRD+ N+L+ KI+DFG++KA+ A T G ++ APE Sbjct: 136 GLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMG--TAQYIAPEQALGHD 193 Query: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDC 575 S SDV+S GV +EA+S G++P+ V + PP+ PP + L+ Sbjct: 194 ASPASDVYSLGVVGYEAVS-GKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVRELIEIT 252 Query: 576 WIYKWEDR 583 + R Sbjct: 253 LVKNPAMR 260 >4X3F-A nrPDB Length = 337 Score = 178 bits (452), Expect = 5e-45, Method: Composition-based stats. Identities = 64/248 (25%), Positives = 108/248 (43%), Gaps = 14/248 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG--TEKADTEEMMREAQIMHQLDNPYIVRL 401 + G G V + V ++ VA+KVLK ++ E EA+ L++P I + Sbjct: 20 IATGGMGQVWEAVDNRLGRR--VAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASV 77 Query: 402 IGVCQAE------ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK 455 +++ LVME+ G PL+ L + + + + ++L Q ++ Sbjct: 78 HDYGESQMNGEGRTAYLVMELVNGEPLNSVL-KRTGRLSLRHALDMLEQTGRALQIAHAA 136 Query: 456 NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK 515 VHRD+ N+L+ KI+DFG++KA+ A T G ++ APE Sbjct: 137 GLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMG--TAQYIAPEQALGHD 194 Query: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDC 575 S SDV+S GV +EA+S G++P+ V + PP+ PP + L+ Sbjct: 195 ASPASDVYSLGVVGYEAVS-GKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVRELIEIT 253 Query: 576 WIYKWEDR 583 + R Sbjct: 254 LVKNPAMR 261 >3M42-A nrPDB Length = 299 Score = 178 bits (452), Expect = 5e-45, Method: Composition-based stats. Identities = 63/297 (21%), Positives = 115/297 (38%), Gaps = 54/297 (18%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL- 393 D+ + LG G G V Q + +++ A+K+L D + RE ++ + Sbjct: 17 DDYKVTSQVLGLGINGKVLQIFNKRTQEKF--ALKML------QDCPKARREVELHWRAS 68 Query: 394 DNPYIVRLIGVCQA-----EALMLVMEMAGGGPLHKFLVGKREE-IPVSNVAELLHQVSM 447 P+IVR++ V + + L++VME GG L + + ++ +E++ + Sbjct: 69 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 128 Query: 448 GMKYLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKALGADDSYYTARSAGKWPLK 504 ++YL N HRD+ N+L + K++DFG +K Sbjct: 129 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT----------------- 171 Query: 505 WYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM---ECP 561 K+ D+WS GV M+ L G P+ G + ++ RM E P Sbjct: 172 --------GEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFP 222 Query: 562 ----PECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKA 614 E E+ L+ + + R + + M + ++KV P T + Sbjct: 223 NPEWSEVSEEVKMLIRNLLKTEPTQRMT---ITEFMNHPWIMQSTKVPQTPLHTSRV 276 >6B2Q-A nrPDB Length = 317 Score = 178 bits (452), Expect = 6e-45, Method: Composition-based stats. Identities = 64/248 (25%), Positives = 108/248 (43%), Gaps = 14/248 (5%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG--TEKADTEEMMREAQIMHQLDNPYIVRL 401 + G G V + V ++ VA+KVLK ++ E EA+ L++P I + Sbjct: 40 IATGGMGQVWEAVDNRLGRR--VAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGIASV 97 Query: 402 IGVCQAE------ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK 455 +++ LVME+ G PL+ L + + + + ++L Q ++ Sbjct: 98 HDYGESQMNGEGRTAYLVMELVNGEPLNSVL-KRTGRLSLRHALDMLEQTGRALQIAHAA 156 Query: 456 NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK 515 VHRD+ N+L+ KI+DFG++KA+ A T G ++ APE Sbjct: 157 GLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMG--TAQYIAPEQALGHD 214 Query: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDC 575 S SDV+S GV +EA+S G++P+ V + PP+ PP + L+ Sbjct: 215 ASPASDVYSLGVVGYEAVS-GKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVRELIEIT 273 Query: 576 WIYKWEDR 583 + R Sbjct: 274 LVKNPAMR 281 >3Q4U-A nrPDB Length = 301 Score = 178 bits (451), Expect = 8e-45, Method: Composition-based stats. Identities = 56/291 (19%), Positives = 109/291 (37%), Gaps = 50/291 (17%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G G +G V +G ++ VA+K+ EK+ E E L + I+ I Sbjct: 16 VGKGRYGEVWRGSWQGEN----VAVKIFSSRDEKSWFRET--ELYNTVMLRHENILGFIA 69 Query: 404 V-----CQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE----- 453 + L L+ G L+ +L + + + ++ ++ G+ +L Sbjct: 70 SDMTSRHSSTQLWLITHYHEMGSLYDYL--QLTTLDTVSCLRIVLSIASGLAHLHIEIFG 127 Query: 454 ---EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK-WPLKWYAPE 509 + HRDL ++N+L+ I+D GL+ + + + ++ APE Sbjct: 128 TQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPE 187 Query: 510 CIN-------FRKFSSRSDVWSYGVTMWE----ALSYG-----QKPYKK----MKGPEVM 549 ++ F + R D+W++G+ +WE +S G + P+ E M Sbjct: 188 VLDETIQVDCFDSY-KRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDM 246 Query: 550 AFI--EQGKRMECP-----PECPPELYALMSDCWIYKWEDRPDFLTVEQRM 593 + +R P L LM +CW R L +++ + Sbjct: 247 RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTL 297 >3BGP-A nrPDB Length = 333 Score = 177 bits (450), Expect = 9e-45, Method: Composition-based stats. Identities = 56/259 (21%), Positives = 110/259 (42%), Gaps = 27/259 (10%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTE-----EMMREAQIMHQLDNPY- 397 LG G FGSV G+ + VAIK +++ E + E ++ ++ + + Sbjct: 64 LGSGGFGSVYSGIR--VSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFS 121 Query: 398 -IVRLIGVCQA-EALMLVMEMAGG-GPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 454 ++RL+ + ++ +L++E L F+ +R + QV +++ Sbjct: 122 GVIRLLDWFERPDSFVLILERPEPVQDLFDFIT-ERGALQEELARSFFWQVLEAVRHCHN 180 Query: 455 KNFVHRDLAARNVLLV-NRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF 513 +HRD+ N+L+ NR K+ DFG L D+ YT + + PE I + Sbjct: 181 CGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVYTDFDGTRV---YSPPEWIRY 235 Query: 514 RKF-SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALM 572 ++ + VWS G+ +++ + G P++ + I +G ++ E L+ Sbjct: 236 HRYHGRSAAVWSLGILLYDMVC-GDIPFEHDEE------IIRG-QVFFRQRVSSECQHLI 287 Query: 573 SDCWIYKWEDRPDFLTVEQ 591 C + DRP F ++ Sbjct: 288 RWCLALRPSDRPTFEEIQN 306 >1PY5-A nrPDB Length = 326 Score = 177 bits (450), Expect = 1e-44, Method: Composition-based stats. Identities = 67/301 (22%), Positives = 117/301 (38%), Gaps = 52/301 (17%) Query: 338 LIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMH--QLDN 395 ++ +G G FG V +G +R +VA+K+ E++ REA+I L + Sbjct: 31 IVLQESIGKGRFGEVWRGKWRGE----EVAVKIFSSREERS----WFREAEIYQTVMLRH 82 Query: 396 PYIVRLIGVCQAEA-----LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMK 450 I+ I + L LV + G L +L R + V + +L + G+ Sbjct: 83 ENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYL--NRYTVTVEGMIKLALSTASGLA 140 Query: 451 YLE--------EKNFVHRDLAARNVLLVNRHYAKISDFGLS-KALGADDSYYTARSAGKW 501 +L + HRDL ++N+L+ I+D GL+ + A D+ A + Sbjct: 141 HLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVG 200 Query: 502 PLKWYAPEC----INFRKFS--SRSDVWSYGVTMWEA---LSYG------QKPYKKM--K 544 ++ APE IN + F R+D+++ G+ WE S G Q PY + Sbjct: 201 TKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPS 260 Query: 545 GPEVMAFIEQGKRMECPPECPPE---------LYALMSDCWIYKWEDRPDFLTVEQRMRA 595 P V + + P P + +M +CW R L +++ + Sbjct: 261 DPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQ 320 Query: 596 C 596 Sbjct: 321 L 321 >3MDY-A nrPDB Length = 337 Score = 177 bits (450), Expect = 1e-44, Method: Composition-based stats. Identities = 65/304 (21%), Positives = 119/304 (39%), Gaps = 50/304 (16%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 ++G G +G V G +R K VA+KV E + E E + + I+ Sbjct: 43 KQIGKGRYGEVWMGKWRGEK----VAVKVFFTTEEASWFRET--EIYQTVLMRHENILGF 96 Query: 402 I-----GVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK- 455 I G L L+ + G L+ +L K + ++ +L + G+ +L + Sbjct: 97 IAADIKGTGSWTQLYLITDYHENGSLYDYL--KSTTLDAKSMLKLAYSSVSGLCHLHTEI 154 Query: 456 -------NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK-WPLKWYA 507 HRDL ++N+L+ I+D GL+ +D + + ++ Sbjct: 155 FSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMP 214 Query: 508 PECI-------NFRKFSSRSDVWSYGVTMWE----ALSYG-----QKPYKK----MKGPE 547 PE + +F+ + +D++S+G+ +WE +S G Q PY E Sbjct: 215 PEVLDESLNRNHFQSY-IMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYE 273 Query: 548 VMAFIEQGKRMEC-------PPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL 600 M I K++ EC ++ LM++CW + R L V++ + S Sbjct: 274 DMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQ 333 Query: 601 ASKV 604 K+ Sbjct: 334 DIKL 337 >4RC3-A nrPDB Length = 289 Score = 177 bits (448), Expect = 2e-44, Method: Composition-based stats. Identities = 56/259 (21%), Positives = 110/259 (42%), Gaps = 27/259 (10%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTE-----EMMREAQIMHQLDNPY- 397 LG G FGSV G+ + VAIK +++ E + E ++ ++ + + Sbjct: 20 LGSGGFGSVYSGIR--VSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFS 77 Query: 398 -IVRLIGVCQA-EALMLVMEMAGG-GPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 454 ++RL+ + ++ +L++E L F+ +R + QV +++ Sbjct: 78 GVIRLLDWFERPDSFVLILERPEPVQDLFDFIT-ERGALQEELARSFFWQVLEAVRHCHN 136 Query: 455 KNFVHRDLAARNVLLV-NRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF 513 +HRD+ N+L+ NR K+ DFG L D+ YT + + PE I + Sbjct: 137 CGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVYTDFDGTRV---YSPPEWIRY 191 Query: 514 RKF-SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALM 572 ++ + VWS G+ +++ + G P++ + I +G ++ E L+ Sbjct: 192 HRYHGRSAAVWSLGILLYDMVC-GDIPFEHDEE------IIRG-QVFFRQRVSSECQHLI 243 Query: 573 SDCWIYKWEDRPDFLTVEQ 591 C + DRP F ++ Sbjct: 244 RWCLALRPSDRPTFEEIQN 262 >3PG1-A nrPDB Length = 362 Score = 177 bits (448), Expect = 2e-44, Method: Composition-based stats. Identities = 56/260 (21%), Positives = 106/260 (40%), Gaps = 32/260 (12%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIK----------VLKQGTEKADTEEMMREAQIMHQL 393 + G++G+V GV + I VAIK + ++ + ++RE ++++ Sbjct: 30 ISSGSYGAVCAGVD---SEGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRLLNHF 86 Query: 394 DNPYIVRLIGVCQA------EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSM 447 +P I+ L + L LV E+ L + + +R I ++ ++ + + Sbjct: 87 HHPNILGLRDIFVHFEEPAMHKLYLVTELMR-TDLAQVIHDQRIVISPQHIQYFMYHILL 145 Query: 448 GMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYA 507 G+ L E VHRDL N+LL + + I DF L++ D+ T +W + A Sbjct: 146 GLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLARE-DTADANKTHYVTHRW---YRA 201 Query: 508 PE-CINFRKFSSRSDVWSYGVTMWEA-----LSYGQKPYKKMKGPEVMAFIEQGKRMECP 561 PE + F+ F+ D+WS G M E L G Y ++ +++ + K + Sbjct: 202 PELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLN--KIVEVVGTPKIEDVV 259 Query: 562 PECPPELYALMSDCWIYKWE 581 P + + Sbjct: 260 MFSSPSARDYLRNSLSNVPA 279 >5AIR-A nrPDB Length = 430 Score = 176 bits (447), Expect = 2e-44, Method: Composition-based stats. Identities = 72/305 (23%), Positives = 112/305 (36%), Gaps = 57/305 (18%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRL 401 +G G+FG V Q ++ VAIK + D RE QIM +LD+ IVRL Sbjct: 70 KVIGNGSFGVVYQA--KLCDSGELVAIKKV-----LQDKRFKNRELQIMRKLDHCNIVRL 122 Query: 402 IGVCQAEA-------LMLVMEMAGGGPLH--KFLVGKREEIPVSNVAELLHQVSMGMKYL 452 + L LV++ + ++ +PV V ++Q+ + Y+ Sbjct: 123 RYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYI 182 Query: 453 EEKNFVHRDLAARNVLLVNRHYA-KISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI 511 HRD+ +N+LL K+ DFG +K L + + + + APE I Sbjct: 183 HSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICS----RYYRAPELI 238 Query: 512 NF-RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKG----PEVMAFIEQGKRMEC------ 560 ++S DVWS G + E L GQ + G E++ + R + Sbjct: 239 FGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPN 297 Query: 561 ------------------PPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLAS 602 P PPE AL S Y R + AC +S Sbjct: 298 YTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLT------PLEACAHSFFD 351 Query: 603 KVEGP 607 ++ P Sbjct: 352 ELRDP 356 >5TUR-A nrPDB Length = 404 Score = 176 bits (446), Expect = 3e-44, Method: Composition-based stats. Identities = 56/259 (21%), Positives = 110/259 (42%), Gaps = 27/259 (10%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTE-----EMMREAQIMHQLDNPY- 397 LG G FGSV G+ + VAIK +++ E + E ++ ++ + + Sbjct: 135 LGSGGFGSVYSGIR--VSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFS 192 Query: 398 -IVRLIGVCQA-EALMLVMEMAGG-GPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 454 ++RL+ + ++ +L++E L F+ +R + QV +++ Sbjct: 193 GVIRLLDWFERPDSFVLILERPEPVQDLFDFIT-ERGALQEELARSFFWQVLEAVRHCHN 251 Query: 455 KNFVHRDLAARNVLLV-NRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINF 513 +HRD+ N+L+ NR K+ DFG L D+ YT + + PE I + Sbjct: 252 CGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVYTDFDGTRV---YSPPEWIRY 306 Query: 514 RKF-SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALM 572 ++ + VWS G+ +++ + G P++ + I +G ++ E L+ Sbjct: 307 HRYHGRSAAVWSLGILLYDMVC-GDIPFEHDEE------IIRG-QVFFRQRVSSECQHLI 358 Query: 573 SDCWIYKWEDRPDFLTVEQ 591 C + DRP F ++ Sbjct: 359 RWCLALRPSDRPTFEEIQN 377 >3REP-A nrPDB Length = 271 Score = 175 bits (444), Expect = 5e-44, Method: Composition-based stats. Identities = 54/253 (21%), Positives = 104/253 (41%), Gaps = 22/253 (8%) Query: 356 VYRMRKKQIDVAIKVLK-QGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA---LM 411 +++ R + D+ +KVLK + + + E + +P ++ ++G CQ+ Sbjct: 26 LWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPAPHPT 85 Query: 412 LVMEMAGGGPLHKFLV-GKREEIPVSNVAELLHQVSMGMKYLE--EKNFVHRDLAARNVL 468 L+ G L+ L G + S + ++ GM +L E L +R+V+ Sbjct: 86 LITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVM 145 Query: 469 LVNRHYAKISDFGLSKALGADDSYYTARSAGK-WPLKWYAPECINFRKFSS---RSDVWS 524 + A+IS D ++ +S G+ + W APE + + + +D+WS Sbjct: 146 IDEDMTARIS---------MADVKFSFQSPGRMYAPAWVAPEALQKKPEDTNRRSADMWS 196 Query: 525 YGVTMWEALSYGQKPYKKMKGPEV-MAFIEQGKRMECPPECPPELYALMSDCWIYKWEDR 583 + V +WE ++ + P+ + E+ M +G R PP P + LM C R Sbjct: 197 FAVLLWELVTR-EVPFADLSNMEIGMKVALEGLRPTIPPGISPHVSKLMKICMNEDPAKR 255 Query: 584 PDFLTVEQRMRAC 596 P F + + Sbjct: 256 PKFDMIVPILEKM 268 >6BFN-A nrPDB Length = 342 Score = 175 bits (444), Expect = 5e-44, Method: Composition-based stats. Identities = 64/319 (20%), Positives = 111/319 (34%), Gaps = 61/319 (19%) Query: 340 ADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKAD---TEEMMREAQIMHQLDNP 396 ++++G G FG V + V R A+K LK+ + + + E + + + +P Sbjct: 26 EELKIGEGGFGCVYRAVMRNT----VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHP 81 Query: 397 YIVRLIGVCQAEALM-LVMEMAGGGPLHKFLVGKREEIP---VSNVAELLHQVSMGMKYL 452 IV G C LV G L L + + P ++L + +++L Sbjct: 82 NIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFL 141 Query: 453 E--EKNFVHRDLAARNVLLVNRHYAKISDFGLSK------ALGADDSYYTARSAGKWPLK 504 + +H D+ + NVLL R K+ DFGL++ + + S + L Sbjct: 142 HQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLA 201 Query: 505 WYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAF------------- 551 + E I + + +D +S+GV + E L+ GQ+ K Sbjct: 202 YLPEEYIKTGRLAVDTDTFSFGVVVLETLA-GQRAVKTHGARTKYLKDLVEEEAEEAGVA 260 Query: 552 ------------------------IEQGKRMECPPECPPE----LYALMSDCWIYKWEDR 583 I + P CPPE L L C + + R Sbjct: 261 LRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRR 320 Query: 584 PDFLTVEQRMRACYYSLAS 602 P V +R+ +A Sbjct: 321 PPMTQVYERLEKLQAVVAG 339 >4LQP-A nrPDB Length = 508 Score = 175 bits (444), Expect = 5e-44, Method: Composition-based stats. Identities = 61/306 (19%), Positives = 106/306 (34%), Gaps = 69/306 (22%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVL--KQGTEKADTEEMMREAQIMHQLDNPYIV 399 +G G FG VR + K A+K L + +K + E ++ D+P++V Sbjct: 108 KVIGKGAFGEVRLVQKKDTGK--IYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSPWVV 165 Query: 400 RLIGVCQA-EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 L Q + L L+ME GG L L+ + + + + + ++ + + F+ Sbjct: 166 SLYYSFQDAQYLYLIMEFLPGGDLMTMLI-RWQLFTEDVTRFYMAECILAIETIHKLGFI 224 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKAL--GADDSYYT-------ARSAGKWPLKW---- 505 HR + N+L+ R + K+SDFGLS D +YY A + P + Sbjct: 225 HRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGISKPGTYNANT 284 Query: 506 ----------------------------------YA-----------PECINFRKFSSRS 520 A PE ++ + Sbjct: 285 TDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYIAPEIFLYQGYGQEC 344 Query: 521 DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKR-MECPPE--CPPELYALMSDCWI 577 D WS G M+E L G P+ E I ++ ++ P + E L+ Sbjct: 345 DWWSLGAIMYECL-IGWPPFCSETPQETYRKIMNFEQTLQFPDDIHISYEAEDLIRRLLT 403 Query: 578 YKWEDR 583 + + R Sbjct: 404 H-ADQR 408 >2RIO-A nrPDB Length = 434 Score = 174 bits (442), Expect = 8e-44, Method: Composition-based stats. Identities = 64/303 (21%), Positives = 122/303 (40%), Gaps = 43/303 (14%) Query: 336 NLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD- 394 NL++++ LG G+ G+V V++ + VA+K + + + E +++ + D Sbjct: 15 NLVVSEKILGYGSSGTV---VFQGSFQGRPVAVKRM----LIDFCDIALMEIKLLTESDD 67 Query: 395 NPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKR------EEIPVSNVAELLHQVSM 447 +P ++R + L + +E+ L + K + N LL Q++ Sbjct: 68 HPNVIRYYCSETTDRFLYIALELCNL-NLQDLVESKNVSDENLKLQKEYNPISLLRQIAS 126 Query: 448 GMKYLEEKNFVHRDLAARNVLLV-------------NRHYAKISDFGLSKALGAD-DSYY 493 G+ +L +HRDL +N+L+ ISDFGL K L + S+ Sbjct: 127 GVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFR 186 Query: 494 TARSAGKWPLKWYAPECIN-------FRKFSSRSDVWSYGVTMWEALSYGQKPYKKM--K 544 T + W APE + R+ + D++S G + LS G+ P+ + Sbjct: 187 TNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSR 246 Query: 545 GPEVMAFIEQGKRMECPPECP--PELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLAS 602 ++ I M+C + E L+S + RP + V + ++ + Sbjct: 247 ESNIIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLR--HPLFWPKSK 304 Query: 603 KVE 605 K+E Sbjct: 305 KLE 307 >6HV0-A nrPDB Length = 416 Score = 174 bits (441), Expect = 1e-43, Method: Composition-based stats. Identities = 66/291 (22%), Positives = 119/291 (40%), Gaps = 29/291 (9%) Query: 330 LFLKRDNLLIADIELGCGNFGS-VRQGVYRMRKKQIDVAIK-VLKQGTEKADTEEMMREA 387 + + + + D+ LG G G+ V +G++ R VA+K +L + AD RE Sbjct: 3 VIVGKISFCPKDV-LGHGAEGTIVYRGMFDNRD----VAVKRILPECFSFAD-----REV 52 Query: 388 QIMHQLD-NPYIVRLIGVCQAEAL-MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQV 445 Q++ + D +P ++R + + +E+ L +++ K LL Q Sbjct: 53 QLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPITLLQQT 111 Query: 446 SMGMKYLEEKNFVHRDLAARNVLL---VNRHYAK--ISDFGLSKALGADDSYYTARSAGK 500 + G+ +L N VHRDL N+L+ K ISDFGL K L ++ RS Sbjct: 112 TSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVP 171 Query: 501 WPLKWYAPECIN---FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKR 557 W APE ++ + D++S G + +S G P+ + Sbjct: 172 GTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPF-GKSLQRQANILLGACS 230 Query: 558 MEC-PPECPPEL--YALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVE 605 ++C PE ++ L+ + RP V + ++SL +++ Sbjct: 231 LDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLK--HPFFWSLEKQLQ 279 >4E7W-A nrPDB Length = 394 Score = 174 bits (440), Expect = 2e-43, Method: Composition-based stats. Identities = 73/327 (22%), Positives = 118/327 (36%), Gaps = 59/327 (18%) Query: 318 PYSDPEEL-----KDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLK 372 P DP ++ D K +R+ +G G+FG V Q + VAIK + Sbjct: 17 PLDDPNKVIKVLASDGKTGEQREIAYTNCKVIGNGSFGVVFQAKLVESDE---VAIKKV- 72 Query: 373 QGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEA-------LMLVMEMAGGGPLH-- 423 D RE QIM + +P +V L + L LV+E Sbjct: 73 ----LQDKRFKNRELQIMRIVKHPNVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRAS 128 Query: 424 KFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLV-NRHYAKISDFGL 482 + ++ +P+ + ++Q+ + Y+ HRD+ +N+LL K+ DFG Sbjct: 129 RHYAKLKQTMPMLLIKLYMYQLLRSLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGS 188 Query: 483 SKALGADDSYYTARSAGKWPLKWYAPECINF-RKFSSRSDVWSYGVTMWEALSYGQKPYK 541 +K L A + + + + APE I +++ D+WS G M E + GQ + Sbjct: 189 AKILIAGEPNVSYICS----RYYRAPELIFGATNYTTNIDIWSTGCVMAELM-QGQPLFP 243 Query: 542 KMKGPEVMAFI---------EQGKRM-------------ECP------PECPPELYALMS 573 G + + I EQ K M P P PP+ L+S Sbjct: 244 GESGIDQLVEIIKVLGTPSREQIKTMNPNYMEHKFPQIRPHPFSKVFRPRTPPDAIDLIS 303 Query: 574 DCWIYKWEDRPDFLTVEQRMRACYYSL 600 Y R +E + L Sbjct: 304 RLLEYTPSAR--LTAIEALCHPFFDEL 328 >4L00-A nrPDB Length = 304 Score = 173 bits (439), Expect = 2e-43, Method: Composition-based stats. Identities = 74/282 (26%), Positives = 120/282 (42%), Gaps = 27/282 (9%) Query: 331 FLKRDNLLIADIELGCGNFGSVRQGVY----RMRKKQIDVAIKVLKQGTEKADTE---EM 383 LK+D L+ LG G + G + IKV+ + + + + Sbjct: 22 ILKKD--LVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAF 79 Query: 384 MREAQIMHQLDNPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELL 442 A +M Q+ + +IV L GVC + ++V E GGPL F+ K + + ++ Sbjct: 80 FEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVA 139 Query: 443 HQVSMGMKYLEEKNFVHRDLAARNVLLVNRH-------YAKISDFGLSKALGADDSYYTA 495 Q++ + YLE+K+ VH ++ +N+LL + K+SD G+ + + Sbjct: 140 KQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITV-------LS 192 Query: 496 RSAGKWPLKWYAPECIN-FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 554 R + W APEC+ + S +D WS+G T+WE G+ P K E F E Sbjct: 193 RQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYES 252 Query: 555 GKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRAC 596 R P C EL LM+ C Y RP F + + + Sbjct: 253 RCRPVTP-SC-KELADLMTRCMNYDPNQRPFFRAIMRDINKL 292 >3MY0-A nrPDB Length = 305 Score = 172 bits (436), Expect = 4e-43, Method: Composition-based stats. Identities = 56/297 (18%), Positives = 108/297 (36%), Gaps = 50/297 (16%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G G +G V +G++ VA+K+ E++ E E L + I+ I Sbjct: 16 VGKGRYGEVWRGLWHGES----VAVKIFSSRDEQSWFRET--EIYNTVLLRHDNILGFIA 69 Query: 404 V-----CQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE----- 453 + L L+ G L+ FL +R+ + L + G+ +L Sbjct: 70 SDMTSRNSSTQLWLITHYHEHGSLYDFL--QRQTLEPHLALRLAVSAACGLAHLHVEIFG 127 Query: 454 ---EKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK-WPLKWYAPE 509 + HRD +RNVL+ + I+D GL+ Y + + ++ APE Sbjct: 128 TQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPE 187 Query: 510 CINFR-------KFSSRSDVWSYGVTMWEA----LSYG-----QKPYKK----MKGPEVM 549 ++ + + +D+W++G+ +WE + G + P+ E M Sbjct: 188 VLDEQIRTDCFESY-KWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDM 246 Query: 550 AFI--EQGKRMECP-----PECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYS 599 + + P L +M +CW R L +++ ++ S Sbjct: 247 KKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNS 303 >4G3E-A nrPDB Length = 352 Score = 172 bits (435), Expect = 6e-43, Method: Composition-based stats. Identities = 70/360 (19%), Positives = 125/360 (34%), Gaps = 45/360 (12%) Query: 259 ASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESP 318 + S A +L + T + ++ L + E +T KP V Sbjct: 18 QGSVSSGQAHSLASLAKTWSSGSAKLQRLGPETEDNEGVLLTEKLKPVDYEYREEV---- 73 Query: 319 YSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKA 378 + + +G G+FG V + + A+K ++ + Sbjct: 74 -----------------HWMTHQPRVGRGSFGEVHRMKDKQTG--FQCAVKKVRLEVFRV 114 Query: 379 DTEEMMREAQIMHQLDNPYIVRLIG-VCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSN 437 + E L +P IV L G V + + + ME+ GG L + L+ + +P Sbjct: 115 E------ELVACAGLSSPRIVPLYGAVREGPWVNIFMELLEGGSLGQ-LIKQMGCLPEDR 167 Query: 438 VAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRH-YAKISDFGLSKALGADDSYYTAR 496 L Q G++YL + +H D+ A NVLL + A + DFG + L D + Sbjct: 168 ALYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLL 227 Query: 497 SAGKWP--LKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 554 + P APE + + ++ D+WS M L G P+ + + I Sbjct: 228 TGDYIPGTETHMAPEVVMGKPCDAKVDIWSSCCMMLHML-NGCHPWTQYFRGPLCLKIAS 286 Query: 555 --GKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQ 612 E PP C P + + + R + + +++ K G + Sbjct: 287 EPPPIREIPPSCAPLTAQAIQEGLRKEPVHRASAMELRRKV--------GKALQEVGGLK 338 >5Y86-A nrPDB Length = 588 Score = 172 bits (435), Expect = 6e-43, Method: Composition-based stats. Identities = 52/251 (20%), Positives = 102/251 (40%), Gaps = 25/251 (9%) Query: 324 ELKDKKLFLKRDNLLIAD---IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADT 380 + + + RD+L +G G+FG V + VY + +Q VA+K+++ EK Sbjct: 192 DADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVAR-VYDHKLRQY-VALKMVR--NEKRFH 247 Query: 381 EEMMREAQIMHQLDNP------YIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVGKREE- 432 + E +I+ L ++ ++ + + E+ L++ + + + Sbjct: 248 RQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQG 306 Query: 433 IPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYA--KISDFGLSKALGADD 490 V V + + + L + +H DL N+LL + + K+ DFG S Sbjct: 307 FSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF----- 361 Query: 491 SYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMA 550 Y + APE I ++S+ D+WS+G + E L+ GQ + + +A Sbjct: 362 -EYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLA 419 Query: 551 FIEQGKRMECP 561 + + M P Sbjct: 420 CMMELLGMPPP 430 >3QD2-B nrPDB Length = 332 Score = 171 bits (433), Expect = 8e-43, Method: Composition-based stats. Identities = 56/329 (17%), Positives = 115/329 (34%), Gaps = 84/329 (25%) Query: 345 GCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGV 404 G G FG V + ++ + AIK ++ + E++MRE + + +L++P IVR Sbjct: 15 GRGGFGVVFEAKNKVDD--CNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNA 72 Query: 405 C----------QAEALML------------------------------------------ 412 + + + L Sbjct: 73 WLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVGQLQPSSP 132 Query: 413 ------VMEMAGGGPLHKFLVGKREEIPVSN--VAELLHQVSMGMKYLEEKNFVHRDLAA 464 M++ L ++ + + + Q++ +++L K +HRDL Sbjct: 133 KVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGLMHRDLKP 192 Query: 465 RNVLLVNRHYAKISDFGLSKALGADDSYYT---------ARSAGKWPLKWYAPECINFRK 515 N+ K+ DFGL A+ D+ T + + +PE I+ Sbjct: 193 SNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSPEQIHGNN 252 Query: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECP----PECPPELYAL 571 +S + D++S G+ ++E L Y E + I + ++ P + P E + + Sbjct: 253 YSHKVDIFSLGLILFELL------YSFSTQMERVRIITDVRNLKFPLLFTQKYPQE-HMM 305 Query: 572 MSDCWIYKWEDRPDFLTVEQRMRACYYSL 600 + D +RP+ + + A + +L Sbjct: 306 VQDMLSPSPTERPEATDIIE--NAIFENL 332 >6GVJ-A nrPDB Length = 429 Score = 170 bits (431), Expect = 2e-42, Method: Composition-based stats. Identities = 70/390 (17%), Positives = 137/390 (35%), Gaps = 58/390 (14%) Query: 256 NSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPE----PARITSPDKPRPMPMD 311 + + + P S P+ T +S+ + D P + Sbjct: 44 TTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQLS 103 Query: 312 TSVYESPYSDP---EELKDKKLFLKRDNLLIAD------------------IELGCGNFG 350 T PY P ++ + + L NL + ++G G Sbjct: 104 T-----PYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSS 158 Query: 351 SVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMR-EAQIMHQLD--NPYIVRLIGV-CQ 406 V Q + +K+ AIK + T + R E +++L + I+RL Sbjct: 159 KVFQVLN---EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEIT 215 Query: 407 AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARN 466 + + +VME G L+ +L K+ P + + + + + VH DL N Sbjct: 216 DQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYW-KNMLEAVHTIHQHGIVHSDLKPAN 273 Query: 467 VLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR------- 519 L+V K+ DFG++ + D+ + + + + PE I S Sbjct: 274 FLIV-DGMLKLIDFGIANQMQP-DTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSK 331 Query: 520 ----SDVWSYGVTMWEALSYGQKPYKKMKGP--EVMAFIEQGKRMECPPECPPELYALMS 573 SDVWS G ++ +YG+ P++++ ++ A I+ +E P +L ++ Sbjct: 332 ISPKSDVWSLGCILYYM-TYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLK 390 Query: 574 DCWIYKWEDRPDFLTVEQRMRACYYSLASK 603 C + R + + + Y + + Sbjct: 391 CCLKRDPKQRIS---IPELLAHPYVQIQTH 417 >4C59-A nrPDB Length = 340 Score = 169 bits (427), Expect = 4e-42, Method: Composition-based stats. Identities = 60/303 (19%), Positives = 117/303 (38%), Gaps = 37/303 (12%) Query: 321 DPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADT 380 D + + + L L + + L G F V + + A+K L E+ Sbjct: 13 DQSDFVGQTVELGELRLRVRRV-LAEGGFAFVYEAQD--VGSGREYALKRL-LSNEEEKN 68 Query: 381 EEMMREAQIMHQLD-NPYIVRL-----IGVCQAEA----LMLVMEMAGGGPLHKFLVGKR 430 +++E M +L +P IV+ IG +++ +L+ E+ G L +FL Sbjct: 69 RAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELC-KGQLVEFLKKME 127 Query: 431 EEIPVS--NVAELLHQVSMGMKYLEEKN--FVHRDLAARNVLLVNRHYAKISDFGLSKAL 486 P+S V ++ +Q ++++ + +HRDL N+LL N+ K+ DFG + + Sbjct: 128 SRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTI 187 Query: 487 GADDSY---------YTARSAGKWPLKWYAPECINFR---KFSSRSDVWSYGVTMWEALS 534 Y + PE I+ + D+W+ G ++ L Sbjct: 188 SHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILY-LLC 246 Query: 535 YGQKPYKKMKGPEVMAFIEQGKRMECPPECP-PELYALMSDCWIYKWEDRPDFLTVEQRM 593 + Q P++ G ++ I GK P + ++L+ E+R V ++ Sbjct: 247 FRQHPFED--GAKLR--IVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQL 302 Query: 594 RAC 596 + Sbjct: 303 QEI 305 >3HMP-A nrPDB Length = 342 Score = 168 bits (426), Expect = 5e-42, Method: Composition-based stats. Identities = 55/265 (20%), Positives = 105/265 (39%), Gaps = 25/265 (9%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMR-EAQIMHQLD--NPYI 398 ++G G V Q + +K+ AIK + T + R E +++L + I Sbjct: 62 KQIGSGGSSKVFQVLN---EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKI 118 Query: 399 VRLIGV-CQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNF 457 +RL + + +VME G L+ +L K+ P + + + + + Sbjct: 119 IRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYW-KNMLEAVHTIHQHGI 176 Query: 458 VHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFS 517 VH DL N L+V K+ DFG++ + D+ + + + + PE I S Sbjct: 177 VHSDLKPANFLIV-DGMLKLIDFGIANQMQP-DTTSVVKDSQVGTVNYMPPEAIKDMSSS 234 Query: 518 SR-----------SDVWSYGVTMWEALSYGQKPYKKMKGP--EVMAFIEQGKRMECPPEC 564 SDVWS G ++ +YG+ P++++ ++ A I+ +E P Sbjct: 235 RENGKSKSKISPKSDVWSLGCILYYM-TYGKTPFQQIINQISKLHAIIDPNHEIEFPDIP 293 Query: 565 PPELYALMSDCWIYKWEDRPDFLTV 589 +L ++ C + R + Sbjct: 294 EKDLQDVLKCCLKRDPKQRISIPEL 318 >4JLC-A nrPDB Length = 657 Score = 168 bits (426), Expect = 6e-42, Method: Composition-based stats. Identities = 59/239 (24%), Positives = 108/239 (45%), Gaps = 20/239 (8%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 ++L + LG G +V +G ++ A+KV + + MRE +++ +L+ Sbjct: 7 NHLWLLSDILGQGATANVFRGRHKKTGD--LYAVKVFNNISFLRPVDVQMREFEVLKKLN 64 Query: 395 NPYIVRLIGVCQ---AEALMLVMEMAGGGPLHKFLVGKREEI--PVSNVAELLHQVSMGM 449 + IV+L + + +L+ME G L+ L P S +L V GM Sbjct: 65 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 124 Query: 450 KYLEEKNFVHRDLAARNVL--LVNRHYA--KISDFGLSKALGADDSYYTARSAGKWPLKW 505 +L E VHRD+ N++ + + K++DFG ++ L D+ + + ++ Sbjct: 125 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 184 Query: 506 YAPECI----NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP----EVMAFIEQGK 556 + + +K+ + D+WS GVT + A + G P++ +GP EVM I GK Sbjct: 185 MYERAVLRKDHQKKYGATVDLWSVGVTFYHA-ATGSLPFRPFEGPRRNKEVMYKIITGK 242 >4H1O-A nrPDB Length = 560 Score = 167 bits (424), Expect = 1e-41, Method: Composition-based stats. Identities = 66/275 (24%), Positives = 104/275 (37%), Gaps = 77/275 (28%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69 +F+ +I+ EAE L G DG FL R + G + LS+ + H I+ G Y Sbjct: 27 WFHPNITGVEAENLLLTRG-VDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG-GYY 84 Query: 70 AIAGGKAHCGPAELCEFYS------RDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAMV 123 + GG+ AEL ++Y ++ +G L+ P N Sbjct: 85 DLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLN-------------------- 124 Query: 124 RDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQT 183 A ER W+H L+ +EAE+ L + Sbjct: 125 -----------------------------CADPTSER--WFHGHLSGKEAEKLLTEKGK- 152 Query: 184 DGKFLLRPRKE-QGTYALSLIYG----------KTVYHYLISQDKAGKYCIPEGTKFDTL 232 G FL+R + G + LS+ G V H +I + + KY + G +FD+L Sbjct: 153 HGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMI-RCQELKYDVGGGERFDSL 211 Query: 233 WQLVEYLKLK----ADGLIYCLKEACPNSSASNAS 263 LVE+ K G + LK+ N++ NA+ Sbjct: 212 TDLVEHYKKNPMVETLGTVLQLKQPL-NTTRINAA 245 Score = 87.0 bits (214), Expect = 2e-17, Method: Composition-based stats. Identities = 43/155 (27%), Positives = 67/155 (43%), Gaps = 19/155 (12%) Query: 2 PDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHD-------- 53 DP + +F+G +S EAE+ L G G FL+R+ G +VLS+ Sbjct: 126 ADPTSE-RWFHGHLSGKEAEKLLTEKG-KHGSFLVRESQSHPGDFVLSVRTGDDKGESND 183 Query: 54 --VRFHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRDPD----GLPCNLRKPCN--RP 105 + H I Q Y + GG+ +L E Y ++P G L++P N R Sbjct: 184 GKSKVTHVMIRCQ-ELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRI 242 Query: 106 SGLEPQPGVFDCLRDAMVRDYVRQTWKLEGEALEQ 140 + E + V + + A D V+Q + E E L+Q Sbjct: 243 NAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQ 277 >4EUU-A nrPDB Length = 319 Score = 167 bits (424), Expect = 1e-41, Method: Composition-based stats. Identities = 59/239 (24%), Positives = 108/239 (45%), Gaps = 20/239 (8%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 ++L + LG G +V +G ++ AIKV + + MRE +++ +L+ Sbjct: 8 NHLWLLSDILGQGATANVFRGRHKKTGD--LFAIKVFNNISFLRPVDVQMREFEVLKKLN 65 Query: 395 NPYIVRLIGVCQ---AEALMLVMEMAGGGPLHKFLVGKREEI--PVSNVAELLHQVSMGM 449 + IV+L + + +L+ME G L+ L P S +L V GM Sbjct: 66 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 125 Query: 450 KYLEEKNFVHRDLAARNVL--LVNRHYA--KISDFGLSKALGADDSYYTARSAGKWPLKW 505 +L E VHR++ N++ + + K++DFG ++ L D+ + + ++ Sbjct: 126 NHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 185 Query: 506 YAPECI----NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP----EVMAFIEQGK 556 + + +K+ + D+WS GVT + A + G P++ +GP EVM I GK Sbjct: 186 MYERAVLRKDHQKKYGATVDLWSIGVTFYHA-ATGSLPFRPFEGPRRNKEVMYKIITGK 243 >5AP3-A nrPDB Length = 313 Score = 167 bits (423), Expect = 1e-41, Method: Composition-based stats. Identities = 55/265 (20%), Positives = 105/265 (39%), Gaps = 25/265 (9%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMR-EAQIMHQLD--NPYI 398 ++G G V Q + +K+ AIK + T + R E +++L + I Sbjct: 34 KQIGSGGSSKVFQVLN---EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKI 90 Query: 399 VRLIGV-CQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNF 457 +RL + + +VME G L+ +L K+ P + + + + + Sbjct: 91 IRLYDYEITDQYIYMVME-CGNIDLNGWLKKKKSIDPWERKSYW-KNMLEAVHTIHQHGI 148 Query: 458 VHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFS 517 VH DL N L+V K+ DFG++ + D+ + + + + PE I S Sbjct: 149 VHSDLKPANFLIV-DGMLKLIDFGIANQMQP-DTTSVVKDSQVGTVNYMPPEAIKDMSSS 206 Query: 518 SR-----------SDVWSYGVTMWEALSYGQKPYKKMKGP--EVMAFIEQGKRMECPPEC 564 SDVWS G ++ +YG+ P++++ ++ A I+ +E P Sbjct: 207 RENGKSKSKISPKSDVWSLGCILYYM-TYGKTPFQQIINQISKLHAIIDPNHEIEFPDIP 265 Query: 565 PPELYALMSDCWIYKWEDRPDFLTV 589 +L ++ C + R + Sbjct: 266 EKDLQDVLKCCLKRDPKQRISIPEL 290 >2ZMD-A nrPDB Length = 390 Score = 167 bits (422), Expect = 2e-41, Method: Composition-based stats. Identities = 55/265 (20%), Positives = 105/265 (39%), Gaps = 25/265 (9%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMR-EAQIMHQLD--NPYI 398 ++G G V Q + +K+ AIK + T + R E +++L + I Sbjct: 62 KQIGSGGSSKVFQVLN---EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKI 118 Query: 399 VRLIGV-CQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNF 457 +RL + + +VME G L+ +L K+ P + + + + + Sbjct: 119 IRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYW-KNMLEAVHTIHQHGI 176 Query: 458 VHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFS 517 VH DL N L+V K+ DFG++ + D+ + + + + PE I S Sbjct: 177 VHSDLKPANFLIV-DGMLKLIDFGIANQMQP-DTTSVVKDSQVGAVNYMPPEAIKDMSSS 234 Query: 518 SR-----------SDVWSYGVTMWEALSYGQKPYKKMKGP--EVMAFIEQGKRMECPPEC 564 SDVWS G ++ +YG+ P++++ ++ A I+ +E P Sbjct: 235 RENGKSKSKISPKSDVWSLGCILYYM-TYGKTPFQQIINQISKLHAIIDPNHEIEFPDIP 293 Query: 565 PPELYALMSDCWIYKWEDRPDFLTV 589 +L ++ C + R + Sbjct: 294 EKDLQDVLKCCLKRDPKQRISIPEL 318 >4EUT-A nrPDB Length = 396 Score = 166 bits (420), Expect = 3e-41, Method: Composition-based stats. Identities = 59/239 (24%), Positives = 108/239 (45%), Gaps = 20/239 (8%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 ++L + LG G +V +G ++ AIKV + + MRE +++ +L+ Sbjct: 8 NHLWLLSDILGQGATANVFRGRHKKTGD--LFAIKVFNNISFLRPVDVQMREFEVLKKLN 65 Query: 395 NPYIVRLIGVCQ---AEALMLVMEMAGGGPLHKFLVGKREEI--PVSNVAELLHQVSMGM 449 + IV+L + + +L+ME G L+ L P S +L V GM Sbjct: 66 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 125 Query: 450 KYLEEKNFVHRDLAARNVL--LVNRHYA--KISDFGLSKALGADDSYYTARSAGKWPLKW 505 +L E VHR++ N++ + + K++DFG ++ L D+ + + ++ Sbjct: 126 NHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 185 Query: 506 YAPECI----NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP----EVMAFIEQGK 556 + + +K+ + D+WS GVT + A + G P++ +GP EVM I GK Sbjct: 186 MYERAVLRKDHQKKYGATVDLWSIGVTFYHA-ATGSLPFRPFEGPRRNKEVMYKIITGK 243 >4TN6-A nrPDB Length = 318 Score = 165 bits (418), Expect = 5e-41, Method: Composition-based stats. Identities = 60/286 (20%), Positives = 116/286 (40%), Gaps = 25/286 (8%) Query: 330 LFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQI 389 + L+ N ++G G+FG + G +++ + ++ +K ++ E++I Sbjct: 1 MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVK-----TKHPQLHIESKI 55 Query: 390 MHQLDNPYIVRLIGVCQAEALM--LVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSM 447 + + I C AE +VME+ G L + + V L Q+ Sbjct: 56 YKMMQGGVGIPTIRWCGAEGDYNVMVMELL-GPSLEDLFNFCSRKFSLKTVLLLADQMIS 114 Query: 448 GMKYLEEKNFVHRDLAARNVLL---VNRHYAKISDFGLSKALGADDSY----YTARSAGK 500 ++Y+ KNF+HRD+ N L+ + I DFGL+K ++ Y Sbjct: 115 RIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLT 174 Query: 501 WPLKWYAPECINFRKFSSRSDVWSYG-VTMWEALSYGQKPYKKMKGPEVMAFIEQG--KR 557 ++ + + S R D+ S G V M+ + G P++ +K E+ K+ Sbjct: 175 GTARYASINTHLGIEQSRRDDLESLGYVLMY--FNLGSLPWQGLKAATKRQKYERISEKK 232 Query: 558 MECP-----PECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYY 598 M P P E ++ C +++D+PD+ + Q R ++ Sbjct: 233 MSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFH 278 >4Y83-A nrPDB Length = 332 Score = 165 bits (417), Expect = 6e-41, Method: Composition-based stats. Identities = 53/253 (20%), Positives = 93/253 (36%), Gaps = 21/253 (8%) Query: 346 CGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG-V 404 G FG V KK++ A K++ K +I + I L G V Sbjct: 83 RGAFGKVYLAQDIKTKKRM--ACKLIPVDQFKPSD------VEIQACFRHENIAELYGAV 134 Query: 405 CQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAA 464 E + L ME GG + + L + + V G+ +L K +H D+ Sbjct: 135 LWGETVHLFMEAGEGGSVLEKLESCGPMR-EFEIIWVTKHVLKGLDFLHSKKVIHHDIKP 193 Query: 465 RNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWS 524 N++ ++ + DFGLS + D + + + +PE I R S+++D++S Sbjct: 194 SNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDL---RGTEIYMSPEVILCRGHSTKADIYS 249 Query: 525 YGVTMWEALSYGQKP----YKKMKGPEVMAFIEQGKRM--ECPPECPPELYALMSDCWIY 578 G T+ G P Y + P + I + + +C P + L+ Sbjct: 250 LGATLIHM-QTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLER 308 Query: 579 KWEDRPDFLTVEQ 591 RP + + Sbjct: 309 NPNHRPRAADLLK 321 >6NT9-A nrPDB Length = 742 Score = 164 bits (416), Expect = 8e-41, Method: Composition-based stats. Identities = 59/239 (24%), Positives = 108/239 (45%), Gaps = 20/239 (8%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 ++L + LG G +V +G ++ AIKV + + MRE +++ +L+ Sbjct: 6 NHLWLLSDILGQGATANVFRGRHKKTGD--LFAIKVFNNISFLRPVDVQMREFEVLKKLN 63 Query: 395 NPYIVRLIGVCQ---AEALMLVMEMAGGGPLHKFLVGKREEI--PVSNVAELLHQVSMGM 449 + IV+L + + +L+ME G L+ L P S +L V GM Sbjct: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 Query: 450 KYLEEKNFVHRDLAARNVL--LVNRHYA--KISDFGLSKALGADDSYYTARSAGKWPLKW 505 +L E VHR++ N++ + + K++DFG ++ L D+ + + ++ Sbjct: 124 NHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 183 Query: 506 YAPECI----NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP----EVMAFIEQGK 556 + + +K+ + D+WS GVT + A + G P++ +GP EVM I GK Sbjct: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHA-ATGSLPFRPFEGPRRNKEVMYKIITGK 241 >6O8B-A nrPDB Length = 665 Score = 164 bits (414), Expect = 1e-40, Method: Composition-based stats. Identities = 59/239 (24%), Positives = 107/239 (44%), Gaps = 20/239 (8%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 ++L + LG G +V +G ++ AIKV + + MRE +++ +L+ Sbjct: 14 NHLWLLSDILGQGATANVFRGRHKKTGD--LFAIKVFNNISFLRPVDVQMREFEVLKKLN 71 Query: 395 NPYIVRLIGVCQ---AEALMLVMEMAGGGPLHKFLVGKREEI--PVSNVAELLHQVSMGM 449 + IV+L + + +L+ME G L+ L P S +L V GM Sbjct: 72 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 131 Query: 450 KYLEEKNFVHRDLAARNVL--LVNRHYA--KISDFGLSKALGADDSYYTARSAGKWPLKW 505 +L E VHR++ N++ + + K++DFG ++ L D+ + ++ Sbjct: 132 NHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPD 191 Query: 506 YAPECI----NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP----EVMAFIEQGK 556 + + +K+ + D+WS GVT + A + G P++ +GP EVM I GK Sbjct: 192 MYERAVLRKDHQKKYGATVDLWSIGVTFYHA-ATGSLPFRPFEGPRRNKEVMYKIITGK 249 >4CRL-A nrPDB Length = 406 Score = 163 bits (413), Expect = 2e-40, Method: Composition-based stats. Identities = 47/217 (21%), Positives = 85/217 (39%), Gaps = 20/217 (9%) Query: 334 RDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL 393 D ++G G +G V + + K D A+K ++ RE ++ +L Sbjct: 20 EDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMS---ACREIALLREL 76 Query: 394 DNPYIVRLIGVCQ---AEALMLVMEMAGGGPLHKFLVGKR--------EEIPVSNVAELL 442 +P ++ L V + L+ + A L + R ++P V LL Sbjct: 77 KHPNVISLQKVFLSHADRKVWLLFDYAEH-DLWHIIKFHRASKANKKPVQLPRGMVKSLL 135 Query: 443 HQVSMGMKYLEEKNFVHRDLAARNVLLV----NRHYAKISDFGLSKALGADDSYYTARSA 498 +Q+ G+ YL +HRDL N+L++ R KI+D G ++ + Sbjct: 136 YQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDP 195 Query: 499 GKWPLKWYAPECINF-RKFSSRSDVWSYGVTMWEALS 534 + APE + R ++ D+W+ G E L+ Sbjct: 196 VVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT 232 >5C01-A nrPDB Length = 342 Score = 162 bits (411), Expect = 3e-40, Method: Composition-based stats. Identities = 76/309 (24%), Positives = 125/309 (40%), Gaps = 44/309 (14%) Query: 319 YSDPEELKDKKLFLKR-DNLLIADI-ELGCGNFGSVRQGVYR------------------ 358 + P L +L R D I + LG G +V +G R Sbjct: 39 RASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPL 98 Query: 359 ----MRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLV 413 R +++ V +KVL A +M Q+ + ++ + GVC + ++V Sbjct: 99 VPGRDRGQELRVVLKVLDPSHHDI-ALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMV 157 Query: 414 MEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLV--- 470 E GPL +L +R +P++ + Q++ + YLE KN VH ++ RN+LL Sbjct: 158 TEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLG 217 Query: 471 ----NRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI--NFRKFSSRSDVWS 524 + K+SD G+ +R + W APEC+ S+ D W Sbjct: 218 LAEGTSPFIKLSDPGV-------GLGALSREERVERIPWLAPECLPGGANSLSTAMDKWG 270 Query: 525 YGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRP 584 +G T+ E G+ P + E F ++ R+ P CP +L L S C Y+ RP Sbjct: 271 FGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEP-SCP-QLATLTSQCLTYEPTQRP 328 Query: 585 DFLTVEQRM 593 F T+ + + Sbjct: 329 SFRTILRDL 337 >4WOV-A nrPDB Length = 317 Score = 162 bits (409), Expect = 5e-40, Method: Composition-based stats. Identities = 65/246 (26%), Positives = 109/246 (44%), Gaps = 20/246 (8%) Query: 358 RMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEM 416 R R +++ V +KVL A +M Q+ + ++ + GVC + ++V E Sbjct: 79 RDRGQELRVVLKVLDPSHHDI-ALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEY 137 Query: 417 AGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLV------ 470 GPL +L +R +P++ + Q++ + YLE KN VH ++ RN+LL Sbjct: 138 VEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAE 197 Query: 471 -NRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI--NFRKFSSRSDVWSYGV 527 + K+SD G+ +R + W APEC+ S+ D W +G Sbjct: 198 GTSPFIKLSDPGV-------GLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGA 250 Query: 528 TMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFL 587 T+ E G+ P + E F ++ R+ P CP +L L S C Y+ RP F Sbjct: 251 TLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEP-SCP-QLATLTSQCLTYEPTQRPSFR 308 Query: 588 TVEQRM 593 T+ + + Sbjct: 309 TILRDL 314 >2WO6-A nrPDB Length = 382 Score = 161 bits (407), Expect = 9e-40, Method: Composition-based stats. Identities = 67/292 (22%), Positives = 108/292 (36%), Gaps = 37/292 (12%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMH-QL 393 D I D +G G+FG V + R+ ++ VAIK++K +KA + E +++ Sbjct: 54 DRYEI-DSLIGKGSFGQVVKAYDRVEQEW--VAIKIIK--NKKAFLNQAQIEVRLLELMN 108 Query: 394 DNP-----YIVRLI-GVCQAEALMLVMEMAGGGPLHKFLVGKREE-IPVSNVAELLHQVS 446 + YIV L L LV EM L+ L + ++ + Q+ Sbjct: 109 KHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSY-NLYDLLRNTNFRGVSLNLTRKFAQQMC 167 Query: 447 MGMKYLE--EKNFVHRDLAARNVLLVN--RHYAKISDFGLSKALGADDSYYTARSAGKWP 502 + +L E + +H DL N+LL N R KI DFG S LG Y Sbjct: 168 TALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRF---- 223 Query: 503 LKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPP 562 + +PE + + D+WS G + E G+ + + M I + + PP Sbjct: 224 --YRSPEVLLGMPYDLAIDMWSLGCILVEM-HTGEPLFSGANEVDQMNKIVE--VLGIPP 278 Query: 563 ECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKA 614 + + R F + + K E P T+K Sbjct: 279 ----------AHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKL 320 >5E8V-A nrPDB Length = 316 Score = 160 bits (406), Expect = 1e-39, Method: Composition-based stats. Identities = 62/305 (20%), Positives = 108/305 (35%), Gaps = 55/305 (18%) Query: 341 DIELGCGNFGSVRQGVYRMRKKQI--DVAIKVLKQGTEKADTEEMMREAQIMH--QLDNP 396 D +G G F V + + + VA+K+ + E I L + Sbjct: 14 DTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFP----YEEYASWKTEKDIFSDINLKHE 69 Query: 397 YIVRLIGVCQAEA-----LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKY 451 I++ + + + L+ G L ++L R I ++ +L ++ G+ + Sbjct: 70 NILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLT--RHVISWEDLRKLGSSLARGIAH 127 Query: 452 LEE---------KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYT-ARSAGKW 501 L VHRDL + N+L+ N + DFGLS L S A S Sbjct: 128 LHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVG 187 Query: 502 PLKWYAPECI-------NFRKFSSRSDVWSYGVTMWEALSYG---------QKPYKKMKG 545 ++ APE + N F ++DV+S + +WE S + P+ K Sbjct: 188 TARYMAPEVLASAMNLENVESF-KQTDVYSMALVLWEMTSRCNAVGEVKDYEPPF-GSKV 245 Query: 546 PE---VMAFIEQGKRMECPPECPP---------ELYALMSDCWIYKWEDRPDFLTVEQRM 593 E V + + PE P + +++CW + E R V +R Sbjct: 246 REHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERF 305 Query: 594 RACYY 598 + Sbjct: 306 SELEH 310 >5FQD-C nrPDB Length = 341 Score = 160 bits (405), Expect = 1e-39, Method: Composition-based stats. Identities = 60/282 (21%), Positives = 119/282 (42%), Gaps = 29/282 (10%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN----PYI 398 ++G G+FG + + +++ V K ++KA +++ E+++ L P+I Sbjct: 26 KIGSGSFGDIYLAINITNGEEVAV-----KLESQKARHPQLLYESKLYKILQGGVGIPHI 80 Query: 399 VRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 R G + + +LVM++ G L + V L Q+ ++Y+ KNF+ Sbjct: 81 -RWYGQ-EKDYNVLVMDLL-GPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFI 137 Query: 459 HRDLAARNVLLVNRHYA-K--ISDFGLSKALGADDSY----YTARSAGKWPLKWYAPECI 511 HRD+ N L+ + K + DFGL+K + + Y ++ + Sbjct: 138 HRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAH 197 Query: 512 NFRKFSSRSDVWSYG-VTMWEALSYGQKPYKKMKGPEVMAFIEQG--KRMECP-----PE 563 + S R D+ S G V M+ + P++ +K E+ K+M P Sbjct: 198 LGIEQSRRDDMESLGYVLMY--FNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKG 255 Query: 564 CPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVE 605 P E ++ C ++E+ PD++ + Q R + +L + + Sbjct: 256 FPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYD 297 >5ZTN-A nrPDB Length = 429 Score = 160 bits (404), Expect = 2e-39, Method: Composition-based stats. Identities = 45/247 (18%), Positives = 91/247 (36%), Gaps = 25/247 (10%) Query: 326 KDKKLFLKRDNLLIAD---IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEE 382 + + + D++ +G G+FG V + K VA+K+++ EK + Sbjct: 84 QGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDH--KVHQHVALKMVR--NEKRFHRQ 139 Query: 383 MMREAQIMHQLDNP------YIVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVGKREE-IP 434 E +I+ L ++ ++ + + E+ L++ + + + Sbjct: 140 AAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLS-MNLYELIKKNKFQGFS 198 Query: 435 VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHY--AKISDFGLSKALGADDSY 492 + V + H + + L + +H DL N+LL + K+ DFG S Sbjct: 199 LPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYT 258 Query: 493 YTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI 552 Y + APE I ++ D+WS G + E L+ G + +A + Sbjct: 259 YIQSRF------YRAPEVILGARYGMPIDMWSLGCILAELLT-GYPLLPGEDEGDQLACM 311 Query: 553 EQGKRME 559 + M Sbjct: 312 IELLGMP 318 >5VD3-A nrPDB Length = 311 Score = 159 bits (403), Expect = 3e-39, Method: Composition-based stats. Identities = 56/277 (20%), Positives = 104/277 (37%), Gaps = 19/277 (6%) Query: 316 ESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKV-LKQG 374 +SP DP + F ++ ++ LG G++G V + R ++ A+K + Sbjct: 42 QSPGYDPS---RPESFFQQSFQRLS--RLGHGSYGEVFK--VRSKEDGRLYAVKRSMSPF 94 Query: 375 TEKADTEEMMREAQIMHQL-DNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREE 432 D + E ++ +P VRL + L L E+ G L + Sbjct: 95 RGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELC-GPSLQQHCEAWGAS 153 Query: 433 IPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSY 492 +P + V L + + +L + VH D+ N+ L R K+ DFGL LG Sbjct: 154 LPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAG-- 211 Query: 493 YTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI 552 A + ++ APE + + + +DV+S G+T+ E + P+ ++ Sbjct: 212 --AGEVQEGDPRYMAPELLQG-SYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGY 268 Query: 553 EQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTV 589 E EL +++ + R + Sbjct: 269 ---LPPEFTAGLSSELRSVLVMMLEPDPKLRATAEAL 302 >2H34-A nrPDB Length = 309 Score = 159 bits (402), Expect = 4e-39, Method: Composition-based stats. Identities = 53/245 (21%), Positives = 101/245 (41%), Gaps = 11/245 (4%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQ--GTEKADTEEMMREAQIMHQLDNPYIVRL 401 +G G G V + ++ VA+K++ + ++ M REA+ +L P++V + Sbjct: 42 VGRGGMGDVYEAED--TVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPHVVPI 99 Query: 402 IGVCQAEALMLV-MEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 + + + V M + G L L + P ++ Q+ + HR Sbjct: 100 HDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPR-AVAIVRQIGSALDAAHAAGATHR 158 Query: 461 DLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRS 520 D+ N+L+ +A + DFG++ A D T L + APE + + R+ Sbjct: 159 DVKPENILVSADDFAYLVDFGIASA--TTDEKLTQLGNTVGTLYYMAPERFSESHATYRA 216 Query: 521 DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG--KRMECPPECPPELYALMSDCWIY 578 D+++ ++E L+ G PY+ + + A I Q + P P A+++ Sbjct: 217 DIYALTCVLYECLT-GSPPYQGDQLSVMGAHINQAIPRPSTVRPGIPVAFDAVIARGMAK 275 Query: 579 KWEDR 583 EDR Sbjct: 276 NPEDR 280 >3G2F-A nrPDB Length = 336 Score = 159 bits (401), Expect = 5e-39, Method: Composition-based stats. Identities = 75/318 (23%), Positives = 115/318 (36%), Gaps = 64/318 (20%) Query: 332 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMH 391 L DNL + ++ +G G +G+V +G R VA+KV A+ + + E I Sbjct: 10 LDLDNLKLLEL-IGRGRYGAVYKGSLDER----PVAVKVFS----FANRQNFINEKNIYR 60 Query: 392 --QLDNPYIVRLI---GVCQAEA---LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLH 443 +++ I R I A+ +LVME G L K+L + S L H Sbjct: 61 VPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSS--CRLAH 118 Query: 444 QVSMGMKYLEEK---------NFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD----- 489 V+ G+ YL + HRDL +RNVL+ N ISDFGLS L + Sbjct: 119 SVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRP 178 Query: 490 DSYYTARSAGKWPLKWYAPECINF-------RKFSSRSDVWSYGVTMWEALSYGQKPYKK 542 A + +++ APE + + D+++ G+ WE + Sbjct: 179 GEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPG 238 Query: 543 MKGPEVMAFIEQG--------------KRMECPPECPPE----------LYALMSDCWIY 578 PE + R + P+ P L + DCW Sbjct: 239 ESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQ 298 Query: 579 KWEDRPDFLTVEQRMRAC 596 E R E+RM Sbjct: 299 DAEARLTAQCAEERMAEL 316 >3SV0-A nrPDB Length = 483 Score = 158 bits (399), Expect = 9e-39, Method: Composition-based stats. Identities = 60/281 (21%), Positives = 114/281 (40%), Gaps = 29/281 (10%) Query: 336 NLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN 395 N ++G G+FG + G ++ VAIK+ K +++ E++I L Sbjct: 7 NKFRLGRKIGSGSFGEIYLGTNIQTNEE--VAIKL---ENVKTKHPQLLYESKIYRILQG 61 Query: 396 ----PYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKY 451 P VR GV + + +LVM++ G L ++ + V L Q+ +++ Sbjct: 62 GTGIPN-VRWFGV-EGDYNVLVMDLL-GPSLEDLFNFCSRKLSLKTVLMLADQMINRVEF 118 Query: 452 LEEKNFVHRDLAARNVLLV---NRHYAKISDFGLSKALGADDSY----YTARSAGKWPLK 504 + K+F+HRD+ N L+ + I DFGL+K ++ Y + Sbjct: 119 VHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTAR 178 Query: 505 WYAPECINFRKFSSRSDVWSYG-VTMWEALSYGQKPYKKMKG---PEVMAFIEQGKRMEC 560 + + + S R D+ S G V M+ G P++ +K + I + K Sbjct: 179 YASVNTHLGIEQSRRDDLESLGYVLMYFL--RGSLPWQGLKAGTKKQKYEKISEKKVATS 236 Query: 561 PP----ECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACY 597 P E + C +++D+PD+ +++ R + Sbjct: 237 IEALCRGYPTEFASYFHYCRSLRFDDKPDYSYLKRLFRDLF 277 >5TE0-A nrPDB Length = 347 Score = 157 bits (396), Expect = 2e-38, Method: Composition-based stats. Identities = 52/271 (19%), Positives = 100/271 (36%), Gaps = 28/271 (10%) Query: 338 LIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD-NP 396 + D L G F V + A+K + E D + RE QIM L + Sbjct: 21 VTVDEVLAEGGFAIVFLVR---TSNGMKCALKRMFVNNEH-DLQVCKREIQIMRDLSGHK 76 Query: 397 YIVRLIGVCQAE-------ALMLVMEMAGGGPLHKFLVGKREE-IPVSNVAELLHQVSMG 448 IV I ++++M+ GG + + + + + V ++ Sbjct: 77 NIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEA 136 Query: 449 MKYLEEKN--FVHRDLAARNVLLVNRHYAKISDFGLSKA-----LGADDSYYTARSAGKW 501 + L + +HRDL N+LL +R + + DFG + + Sbjct: 137 VARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYT 196 Query: 502 PLKWYAPECIN---FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM 558 L + APE +N + ++++D+W+ G +++ L Y P+ G +A + + Sbjct: 197 TLSYRAPEMVNLYSGKIITTKADIWALGCLLYK-LCYFTLPF----GESQVAICDGNFTI 251 Query: 559 ECPPECPPELYALMSDCWIYKWEDRPDFLTV 589 +++ L+ + RPD V Sbjct: 252 PDNSRYSQDMHCLIRYMLEPDPDKRPDIYQV 282 >5IKW-A nrPDB Length = 310 Score = 157 bits (396), Expect = 2e-38, Method: Composition-based stats. Identities = 49/279 (17%), Positives = 96/279 (34%), Gaps = 27/279 (9%) Query: 329 KLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQ 388 ++F + + + L G F +V I A+K + RE Sbjct: 7 RVFAVGRHQVTLEESLAEGGFSTVFLVR---THGGIRCALKRMYVNNMPDLNVC-KREIT 62 Query: 389 IMHQLD-NPYIVRLIGVCQAE------ALMLVMEMAGGGPLHKFLVGKREE-IPVSNVAE 440 IM +L + IV + ++++ME G + + K + V + Sbjct: 63 IMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQ 122 Query: 441 LLHQVSMGMKYLEEKN--FVHRDLAARNVLLVNRHYAKISDFGLSKA-----LGADDSYY 493 + + L + +HRDL N+LL + + DFG + + Sbjct: 123 IFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVV 182 Query: 494 TARSAGKWPLKWYAPECIN---FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMA 550 L + APE IN + ++++D+W+ G +++ + P+ G +A Sbjct: 183 EEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFF-TLPF----GESQVA 237 Query: 551 FIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTV 589 + + ++ L+ E RPD V Sbjct: 238 ICDGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQV 276 >3E3P-A nrPDB Length = 360 Score = 155 bits (392), Expect = 5e-38, Method: Composition-based stats. Identities = 58/246 (23%), Positives = 96/246 (39%), Gaps = 32/246 (13%) Query: 327 DKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMRE 386 D++ + D + + G G FG+V+ G + + + VAIK + Q + RE Sbjct: 15 DERSRKEMDRFQVERMA-GQGTFGTVQLG--KEKSTGMSVAIKKVIQDPRFRN-----RE 66 Query: 387 AQIMHQL---DNPYIVRLIGVCQA------EALML--VMEMAGGGPLHKFLV---GKREE 432 QIM L +P IV+L + L VME LH+ ++ Sbjct: 67 LQIMQDLAVLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVP-DTLHRCCRNYYRRQVA 125 Query: 433 IPVSNVAELLHQVSMGMKYLE--EKNFVHRDLAARNVLLVN-RHYAKISDFGLSKALGAD 489 P + L Q+ + L N HRD+ NVL+ K+ DFG +K L Sbjct: 126 PPPILIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPS 185 Query: 490 DSYYTARSAGKWPLKWYAPECINF-RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEV 548 + A + APE I + +++ D+WS G E + G+ ++ Sbjct: 186 EP----NVAYICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMM-LGEPIFRGDNSAGQ 240 Query: 549 MAFIEQ 554 + I + Sbjct: 241 LHEIVR 246 >3EB0-A nrPDB Length = 383 Score = 154 bits (390), Expect = 9e-38, Method: Composition-based stats. Identities = 64/341 (18%), Positives = 115/341 (33%), Gaps = 87/341 (25%) Query: 341 DIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVR 400 LG G+FG V + K+ A+K + Q + RE IM LD+ I++ Sbjct: 12 GKTLGTGSFGIVCEVFDIESGKRF--ALKKVLQDPRYKN-----RELDIMKVLDHVNIIK 64 Query: 401 LIGVC---------------------------------------QAEALMLVMEMAGGGP 421 L+ Q + L ++ME Sbjct: 65 LVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVP-DT 123 Query: 422 LHKFL---VGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN-RHYAKI 477 LHK L + IP++ ++ ++Q+ + ++ HRD+ +N+L+ + + K+ Sbjct: 124 LHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLKL 183 Query: 478 SDFGLSKALGADDSYYTARSAGKWPLKWYAPE-CINFRKFSSRSDVWSYGVTMWEALSYG 536 DFG +K L + A ++ + APE + +++ D+WS G E + G Sbjct: 184 CDFGSAKKLIPSEPS-VAYICSRF---YRAPELMLGATEYTPSIDLWSIGCVFGELI-LG 238 Query: 537 QKPYKKMKGPEVMAFI---------EQGKRME-------------------CPPECPPEL 568 + + + + I EQ RM P P Sbjct: 239 KPLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKILPEGTPSLA 298 Query: 569 YALMSDCWIYKWEDR--PDFLTVEQRMRACYYSLASKVEGP 607 L+ Y+ + R P S S+V+ Sbjct: 299 IDLLEQILRYEPDLRINPYEAMAHPFFDHLRNSYESEVKNN 339 >2WTK-B nrPDB Length = 373 Score = 152 bits (385), Expect = 3e-37, Method: Composition-based stats. Identities = 53/320 (16%), Positives = 100/320 (31%), Gaps = 65/320 (20%) Query: 331 FLKRDNLLIADIELGCGNFG---SVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMR-E 386 FL +G G F +V Y+ + + V + + + ++ E Sbjct: 4 FLPEGGCYELLTVIGKG-FEDLMTVNLARYKPTGEYVTV--RRINLEACSNEMVTFLQGE 60 Query: 387 AQIMHQLDNPYIVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREE-IPVSNVAELLHQ 444 + ++P IV A+ L +V G + + + +A +L Sbjct: 61 LHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQG 120 Query: 445 VSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWP-- 502 V + Y+ +VHR + A ++L+ +S GL L R +P Sbjct: 121 VLKALDYIHHMGYVHRSVKASHILISVDGKVYLS--GLRSNLSMISHGQRQRVVHDFPKY 178 Query: 503 ----LKWYAPECINF--RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK 556 L W +PE + + + ++SD++S G+T E L+ G P+K M +++ G Sbjct: 179 SVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACE-LANGHVPFKDMPATQMLLEKLNGT 237 Query: 557 RM----------------------------------ECPPE-----------CPPELYAL 571 P P + Sbjct: 238 VPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHF 297 Query: 572 MSDCWIYKWEDRPDFLTVEQ 591 + C + RP T+ Sbjct: 298 VEQCLQRNPDARPSASTLLN 317 >6FYV-A nrPDB Length = 337 Score = 152 bits (385), Expect = 3e-37, Method: Composition-based stats. Identities = 61/339 (17%), Positives = 114/339 (33%), Gaps = 83/339 (24%) Query: 334 RDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL 393 R I D LG G FG V + + + VA+K++K E E Q++ L Sbjct: 13 RARYEIVDT-LGEGAFGKVVECIDHGMD-GMHVAVKIVKNVG--RYREAARSEIQVLEHL 68 Query: 394 DN--PY----IVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVS 446 ++ P V+++ + +V E+ G + ++ ++ +Q+ Sbjct: 69 NSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQIC 128 Query: 447 MGMKYLEEKNFVHRDLAARNVLLV-------------------NRHYAKISDFGLSKALG 487 + +L H DL N+L V K+ DFG + Sbjct: 129 QSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATY-- 186 Query: 488 ADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPE 547 DD +++ + + + APE I +S DVWS G + E G ++ E Sbjct: 187 -DDEHHSTLVSTR---HYRAPEVILALGWSQPCDVWSIGCILIEYY-LGFTVFQTHDSKE 241 Query: 548 VMAFIEQ-------------------------------------------GKRMECPPEC 564 +A +E+ + M C E Sbjct: 242 HLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEE 301 Query: 565 PPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASK 603 +L+ L+ Y R +T+++ ++ ++ L K Sbjct: 302 HEKLFDLVRRMLEYDPTQR---ITLDEALQHPFFDLLKK 337 >5X8I-B nrPDB Length = 346 Score = 152 bits (384), Expect = 5e-37, Method: Composition-based stats. Identities = 59/338 (17%), Positives = 113/338 (33%), Gaps = 85/338 (25%) Query: 336 NLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD- 394 I D LG G FG V + + + VA+K++K E E Q++ L+ Sbjct: 14 RYEIVDT-LGEGAFGKVVECID-HKAGGRHVAVKIVKNVD--RYCEAARSEIQVLEHLNT 69 Query: 395 -NPY----IVRLIGVCQAEA-LMLVMEMAGGGPLHKFLVGKRE-EIPVSNVAELLHQVSM 447 +P V+++ + + +V E+ G + F+ + ++ ++ +Q+ Sbjct: 70 TDPNSTFRCVQMLEWFEHHGHICIVFELLGLST-YDFIKENGFLPFRLDHIRKMAYQICK 128 Query: 448 GMKYLEEKNFVHRDLAARNVLLVN-------------------RHYAKISDFGLSKALGA 488 + +L H DL N+L V K+ DFG + Sbjct: 129 SVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATY--- 185 Query: 489 DDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEV 548 DD +++ + + + APE I +S DVWS G + E G + E Sbjct: 186 DDEHHSTLVSTR---HYRAPEVILALGWSQPCDVWSIGCILIEYY-LGFTVFPTHDSKEH 241 Query: 549 MAFIEQ--------------------GKRMECPPECP----------------------- 565 +A +E+ R++ Sbjct: 242 LAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEH 301 Query: 566 PELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASK 603 L+ L+ Y R +T+ + ++ ++ L K Sbjct: 302 ERLFDLIQKMLEYDPAKR---ITLREALKHPFFDLLKK 336 >5J0A-A nrPDB Length = 300 Score = 151 bits (382), Expect = 8e-37, Method: Composition-based stats. Identities = 57/286 (19%), Positives = 109/286 (38%), Gaps = 33/286 (11%) Query: 342 IELGCGNFGSVRQGVYRMRK-KQIDVAIKVLKQGTEKADT----EEMMREAQIMHQLDNP 396 +LG G +V R A+K + + +M EA+I+ L +P Sbjct: 15 QKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLHHP 74 Query: 397 YIVRLIGVCQAE--ALMLVMEMAGGGPLHKFLVGK----REEIPVSNVAELLHQVSMGMK 450 IV +A +L L ME G L+ + + ++ P + + ++ ++ G+K Sbjct: 75 NIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARGLK 134 Query: 451 YLE-EKNFVHRDLAARNVLLVNRH-YAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 YL EK +H D+ + NV++ KI D G+S L + + W Sbjct: 135 YLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEPWKPK 194 Query: 509 ECINFRK-FSSRSDVWSYGVTMWEALSYGQKP--------------YKKMKGPEVMAFIE 553 E + + ++D++++G+T+WE ++ P + + + + Sbjct: 195 EAVEENGVITDKADIFAFGLTLWEMMTL-SIPHINLSNDDDDEDKTFDESDFDDEAYYAA 253 Query: 554 QGKRMECPPECPPE----LYALMSDCWIYKWEDRPDFLTVEQRMRA 595 G R E E + L S C +DRP + + + Sbjct: 254 LGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVEALET 299 >3SOC-A nrPDB Length = 322 Score = 148 bits (373), Expect = 8e-36, Method: Composition-based stats. Identities = 58/301 (19%), Positives = 109/301 (36%), Gaps = 51/301 (16%) Query: 324 ELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEM 383 +L + L+ + L + +++ G FG V + VA+K+ +++ E Sbjct: 13 DLGTENLYFQSMPLQLLEVK-ARGRFGCVWKAQLLNE----YVAVKIFPIQDKQSWQNEY 67 Query: 384 MREAQIMHQLDNPYIVRLIGVCQAEA-----LMLVMEMAGGGPLHKFLVGKREEIPVSNV 438 E + + + I++ IG + L L+ G L FL + + + Sbjct: 68 --EVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKAN--VVSWNEL 123 Query: 439 AELLHQVSMGMKYLEE----------KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGA 488 + ++ G+ YL E HRD+ ++NVLL N A I+DFGL+ A Sbjct: 124 CHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEA 183 Query: 489 DDSYYTARSAGKWPLKWYAPECINF-----RKFSSRSDVWSYGVTMWEALSYGQ------ 537 S ++ APE + R R D+++ G+ +WE S Sbjct: 184 GKS-AGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPV 242 Query: 538 ----KPY-----KKMKGPEVMAFIEQGKRMECPPEC------PPELYALMSDCWIYKWED 582 P+ + ++ + K+ + L + +CW + E Sbjct: 243 DEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEA 302 Query: 583 R 583 R Sbjct: 303 R 303 >4IAN-A nrPDB Length = 358 Score = 144 bits (364), Expect = 9e-35, Method: Composition-based stats. Identities = 49/222 (22%), Positives = 91/222 (40%), Gaps = 20/222 (9%) Query: 345 GCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL------DNPYI 398 G G F +V + R Q +VA+K+++ T ++E + + +L D + Sbjct: 39 GQGVFSNVVRARDNARANQ-EVAVKIIRNNELMQKTG--LKELEFLKKLNDADPDDKFHC 95 Query: 399 VRLI-GVCQAEALMLVMEMAGGGPLHKFLV--GKREEIPVSNVAELLHQVSMGMKYLEEK 455 +RL + L LV E L + L GK + + V Q+ + +K L+ Sbjct: 96 LRLFRHFYHKQHLCLVFEPLS-MNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRC 154 Query: 456 NFVHRDLAARNVLLVNRHYA-KISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR 514 N +H D+ N+L+ K+ DFG + + +D + + APE I + Sbjct: 155 NILHADIKPDNILVNESKTILKLCDFGSASHVADNDI-----TPYLVSRFYRAPEIIIGK 209 Query: 515 KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK 556 + D+WS G T++E + G+ + ++ K Sbjct: 210 SYDYGIDMWSVGCTLYELYT-GKILFPGKTNNHMLKLAMDLK 250 >6O6Q-A nrPDB Length = 335 Score = 144 bits (363), Expect = 1e-34, Method: Composition-based stats. Identities = 44/228 (19%), Positives = 95/228 (41%), Gaps = 21/228 (9%) Query: 333 KRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQ 392 ++N I +LG G + V G+ ++++ V IKVLK +++ RE I+ Sbjct: 39 PQENYEILR-KLGRGKYSEVFLGIDLEKREK--VVIKVLK----PVKRKKIKREISILKN 91 Query: 393 L-DNPYIVRLIGVC---QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMG 448 L D P I+ ++ V Q++ L+ E ++ ++++ Sbjct: 92 LVDGPNIIAMLDVVREPQSKTPGLIFEHINNIDFRSL----YPTFTDYDIRFYMYELLKA 147 Query: 449 MKYLEEKNFVHRDLAARNVLLVNRHY-AKISDFGLSKALGADDSYYTARSAGKWPLKWYA 507 + Y +HRD+ NV++ + ++ D+GL+ + Y R A ++ Sbjct: 148 LDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLA-EYYHPGTEYNVRVASRYFKG--- 203 Query: 508 PECI-NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 554 PE + ++R + D+WS+G + + + + + + I + Sbjct: 204 PELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVR 251 >3RAW-A nrPDB Length = 381 Score = 144 bits (363), Expect = 1e-34, Method: Composition-based stats. Identities = 46/239 (19%), Positives = 94/239 (39%), Gaps = 40/239 (16%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL---DNPYIVR 400 LG G FG V + + R K VA+K+++ + + + E ++ ++ D + Sbjct: 59 LGEGTFGKVVECLDHARGKS-QVALKIIRNVGKYREAARL--EINVLKKIKEKDKEN--K 113 Query: 401 LIGVCQAE------ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 454 + V ++ + + E+ G + P+ +V + +Q+ +++L E Sbjct: 114 FLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHE 173 Query: 455 KNFVHRDLAARNVLLVN-------------------RHYAKISDFGLSKALGADDSYYTA 495 H DL N+L VN +++DFG + D ++T Sbjct: 174 NQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSA---TFDHEHHTT 230 Query: 496 RSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 554 A + + PE I ++ DVWS G ++E G ++ + E + +E+ Sbjct: 231 IVATR---HYRPPEVILELGWAQPCDVWSIGCILFEYY-RGFTLFQTHENREHLVMMEK 285 >5UNP-A nrPDB Length = 369 Score = 143 bits (362), Expect = 1e-34, Method: Composition-based stats. Identities = 52/237 (21%), Positives = 92/237 (38%), Gaps = 36/237 (15%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL-----DNPYI 398 LG G FG V Q V R+ VA+K++K + + + E ++ ++ DN + Sbjct: 42 LGEGTFGRVVQCVD-HRRGGARVALKIIKNVEKYKEAARL--EINVLEKINEKDPDNKNL 98 Query: 399 -VRLIGVCQAEALMLV-MEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 V++ M + E+ G P+ V + Q+ +K+L + Sbjct: 99 CVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNK 158 Query: 457 FVHRDLAARNVLLVNRHY-------------------AKISDFGLSKALGADDSYYTARS 497 H DL N+L VN Y ++ DFG + D +++ Sbjct: 159 LTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSA---TFDHEHHSTIV 215 Query: 498 AGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 554 + + + APE I +S DVWS G ++E G ++ E +A +E+ Sbjct: 216 STR---HYRAPEVILELGWSQPCDVWSIGCIIFEYY-VGFTLFQTHDNREHLAMMER 268 >5VDK-A nrPDB Length = 297 Score = 143 bits (362), Expect = 2e-34, Method: Composition-based stats. Identities = 52/289 (17%), Positives = 106/289 (36%), Gaps = 44/289 (15%) Query: 334 RDNLLIADIE-LGCGNFGSVRQGVYRMRKKQIDVAIKV-LKQGTEKADTEEMMREAQIMH 391 R ++E +G G FG+V + + R+ AIK +K TE ++ + E Sbjct: 12 RYEKEFLEVEKIGVGEFGTVYKCIKRL--DGCVYAIKRSMKTFTELSNENSALHEVYAHA 69 Query: 392 QL-DNPYIVRLIGVCQAEALMLVM-EMAGGGPLHKFL---VGKREEIPVSNVAELLHQVS 446 L +P++VR + M++ E GG L + + ++L Q+S Sbjct: 70 VLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQIS 129 Query: 447 MGMKYLEEKNFVHRDLAARNVLLVNRHYA-----------------------KISDFGLS 483 +G+ Y+ + VH D+ N+ + ++ + KI D G + Sbjct: 130 LGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHA 189 Query: 484 KALGADDSYYTARSAGKWPLKWYAPECINFR-KFSSRSDVWSYGVTMWEALSYGQKPYKK 542 ++ + ++ A E + + ++D+++ G+T+ A P Sbjct: 190 TSINKPK-------VEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLP--- 239 Query: 543 MKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQ 591 I +G + P E +L+ + E RP + + Sbjct: 240 -TNGAAWHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAALAR 287 >5VC6-A nrPDB Length = 289 Score = 142 bits (359), Expect = 4e-34, Method: Composition-based stats. Identities = 52/276 (18%), Positives = 103/276 (37%), Gaps = 41/276 (14%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE-KADTEEMMREAQIMHQL-DNPYIVR 400 ++G G FGSV + V R+ AIK K+ D + +RE L + ++VR Sbjct: 18 KIGSGEFGSVFKCVKRL--DGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVR 75 Query: 401 LIGVC-QAEALMLVMEMAGGGPLHKFLVGK---REEIPVSNVAELLHQVSMGMKYLEEKN 456 + + +++ E GG L + + + +LL QV G++Y+ + Sbjct: 76 YFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMS 135 Query: 457 FVHRDLAARNVLL-------------VNRHYA------KISDFGLSKALGADDSYYTARS 497 VH D+ N+ + +A KI D G + + Sbjct: 136 LVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQ------- 188 Query: 498 AGKWPLKWYAPECINFRKFSS--RSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG 555 + ++ A E + ++ ++D+++ +T+ + G +P + + I QG Sbjct: 189 VEEGDSRFLANEVLQEN-YTHLPKADIFALALTV--VCAAGAEPLP--RNGDQWHEIRQG 243 Query: 556 KRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQ 591 + P E L+ E RP + + + Sbjct: 244 RLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVK 279 >2QLU-A nrPDB Length = 314 Score = 142 bits (357), Expect = 6e-34, Method: Composition-based stats. Identities = 62/315 (19%), Positives = 114/315 (36%), Gaps = 56/315 (17%) Query: 332 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMH 391 + R +L + +I+ G FG V + VA+K+ D + E +I Sbjct: 12 VPRGSLQLLEIK-ARGRFGCVWKAQLM----NDFVAVKIFPL----QDKQSWQSEREIFS 62 Query: 392 Q--LDNPYIVRLIGVCQAEA-----LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQ 444 + + +++ I + + L L+ G L +L G I + + + Sbjct: 63 TPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNI--ITWNELCHVAET 120 Query: 445 VSMGMKYLEE-----------KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYY 493 +S G+ YL E + HRD ++NVLL + A ++DFGL+ Sbjct: 121 MSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKP-P 179 Query: 494 TARSAGKWPLKWYAPECINF-----RKFSSRSDVWSYGVTMWEALSYGQ----------K 538 ++ APE + R R D+++ G+ +WE +S + Sbjct: 180 GDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYML 239 Query: 539 PY-----KKMKGPEVMAFIEQGKRMECPPEC---PPELYAL---MSDCWIYKWEDRPDFL 587 P+ + E+ + K + P L L + +CW + E R Sbjct: 240 PFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAG 299 Query: 588 TVEQRMRACYYSLAS 602 VE+R+ S+ Sbjct: 300 CVEERVSLIRRSVNG 314 >6AMW-A nrPDB Length = 255 Score = 139 bits (351), Expect = 3e-33, Method: Composition-based stats. Identities = 38/113 (33%), Positives = 56/113 (49%), Gaps = 3/113 (2%) Query: 155 TTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSLIYGKTVYHYLI 213 + E+ WYH ++R AE L SG +G FL+R + G ++SL Y VYHY I Sbjct: 138 VNSLEKHSWYHGPVSRNAAEYLLSSG--INGSFLVRESESSPGQRSISLRYEGRVYHYRI 195 Query: 214 SQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAA 266 + GK + ++F+TL +LV + ADGLI L P + G + Sbjct: 196 NTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVS 248 Score = 115 bits (288), Expect = 6e-26, Method: Composition-based stats. Identities = 32/112 (28%), Positives = 56/112 (50%), Gaps = 7/112 (6%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69 +++G +SR A E+L +G+ +G FL+R+ S G +SL ++ R +H+ I +G Sbjct: 146 WYHGPVSR-NAAEYLLSSGI-NGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKL 203 Query: 70 AIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPC---NRPS--GLEPQPGVFD 116 ++ AEL +S DGL L P N+P+ G+ P ++ Sbjct: 204 YVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWE 255 >3T04-A nrPDB Length = 123 Score = 138 bits (347), Expect = 9e-33, Method: Composition-based stats. Identities = 38/113 (33%), Positives = 56/113 (49%), Gaps = 3/113 (2%) Query: 155 TTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSLIYGKTVYHYLI 213 + E+ WYH ++R AE L SG +G FL+R + G ++SL Y VYHY I Sbjct: 10 VNSLEKHSWYHGPVSRNAAEYLLSSG--INGSFLVRESESSPGQRSISLRYEGRVYHYRI 67 Query: 214 SQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAA 266 + GK + ++F+TL +LV + ADGLI L P + G + Sbjct: 68 NTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVS 120 Score = 113 bits (284), Expect = 2e-25, Method: Composition-based stats. Identities = 32/107 (29%), Positives = 54/107 (50%), Gaps = 7/107 (6%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69 +++G +SR A E+L +G+ +G FL+R+ S G +SL ++ R +H+ I +G Sbjct: 18 WYHGPVSR-NAAEYLLSSGI-NGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKL 75 Query: 70 AIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPC---NRPS--GLEPQ 111 ++ AEL +S DGL L P N+P+ G+ P Sbjct: 76 YVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPN 122 >2LQW-A nrPDB Length = 303 Score = 137 bits (345), Expect = 1e-32, Method: Composition-based stats. Identities = 37/137 (27%), Positives = 60/137 (43%), Gaps = 5/137 (3%) Query: 156 TAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSLIYGKTVYHYLIS 214 + +R WY ++R+EA+ +L Q G FL+R G Y LS+ V HY+I+ Sbjct: 7 DSSDRSAWYMGPVSRQEAQTRL--QGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIIN 64 Query: 215 QDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHP 274 ++ I + +FD L L+E+ K+ L E P + +AP LP Sbjct: 65 SLPNRRFKIGD-QEFDHLPALLEFYKIHYLDT-TTLIEPAPRYPSPPMGSVSAPNLPTAE 122 Query: 275 STLTHPQRRIDTLNSDG 291 L + + D +D Sbjct: 123 DNLEYVRTLYDFPGNDA 139 Score = 98.5 bits (244), Expect = 7e-21, Method: Composition-based stats. Identities = 50/205 (24%), Positives = 72/205 (35%), Gaps = 23/205 (11%) Query: 3 DPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIE 62 D + ++ G +SR EA+ +L G G+FL+R G YVLS+ + R H+ I Sbjct: 7 DSSDRSAWYMGPVSRQEAQ--TRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIIN 64 Query: 63 RQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNR----PSGLEPQPGVFDCL 118 N + I + PA L EFY L +P R P G P Sbjct: 65 SLPNRRFKIGDQEFDHLPA-LLEFYKIHY-LDTTTLIEPAPRYPSPPMGSVSAPN-LPTA 121 Query: 119 RDAMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYH-------SSLTRE 171 D + +YVR + G E + E L+ E W + Sbjct: 122 EDNL--EYVRTLYDFPGNDAEDLPFKKG---EILVIIEKPEEQWWSARNKDGRVGMIPVP 176 Query: 172 EAERKLYSGAQTDGKFLLRPRKEQG 196 E+ + S GK R G Sbjct: 177 YVEKLVRSS--PHGKHGNRNSNSYG 199 >4XHH-A nrPDB Length = 403 Score = 135 bits (340), Expect = 6e-32, Method: Composition-based stats. Identities = 48/277 (17%), Positives = 107/277 (38%), Gaps = 23/277 (8%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ++G G+FG + G + +++ ++ + ++ ++ E+++ L + I Sbjct: 14 KIGSGSFGDIYHGTNLISGEEVA-----IRLESIRSRHPQLDYESRVYKYLSGGVGIPFI 68 Query: 403 GVCQAEALM--LVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 E +V+++ G L + V L Q+ ++Y+ ++F+HR Sbjct: 69 RWFGREGEYNAMVIDLL-GPSLEDLFNYCHRKFSFKTVIMLALQMICRVQYIHGRSFIHR 127 Query: 461 DLAARNVLLV---NRHYAKISDFGLSKALGADDSY----YTARSAGKWPLKWYAPECINF 513 D+ N L+ + DFGLSK +++ Y + ++ + Sbjct: 128 DIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTHLG 187 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG--KRMECP-----PECPP 566 + S R D+ S G + G P++ +K ++ K++ P Sbjct: 188 IEQSRRDDLESLGYMLIY-FCKGSLPWQGLKATTKKQKYDRILEKKLCISVETLCAGLPL 246 Query: 567 ELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASK 603 E M+ C K+++RPD+L + + + L Sbjct: 247 EFSEYMNYCRNLKFDERPDYLYLARLFKDLSIKLEYH 283 >2B3O-A nrPDB Length = 532 Score = 133 bits (336), Expect = 2e-31, Method: Composition-based stats. Identities = 57/264 (21%), Positives = 96/264 (36%), Gaps = 75/264 (28%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69 +F+ +S +AE LK G G FL R ++ G + LS+ + H I+ + Y Sbjct: 4 WFHRDLSGLDAETLLKGRG-VHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGD-FY 61 Query: 70 AIAGGKAHCGPAELCEFYS------RDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAMV 123 + GG+ EL E+Y+ +D DG +L+ P N Sbjct: 62 DLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLN-------------------- 101 Query: 124 RDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQT 183 + ER WYH ++ +AE L + + Sbjct: 102 -----------------------------CSDPTSER--WYHGHMSGGQAETLLQAKGEP 130 Query: 184 DGKFLLRPR-KEQGTYALSLIYGK---------TVYHYLISQDKAGKYCIPEGTKFDTLW 233 FL+R + G + LS++ + V H + + G+Y + FD+L Sbjct: 131 -WTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCE-GGRYTVGGLETFDSLT 188 Query: 234 QLVEYLKL----KADGLIYCLKEA 253 LVE+ K +A G L++ Sbjct: 189 DLVEHFKKTGIEEASGAFVYLRQP 212 Score = 85.8 bits (211), Expect = 5e-17, Method: Composition-based stats. Identities = 37/102 (36%), Positives = 47/102 (46%), Gaps = 9/102 (8%) Query: 163 WYHSSLTREEAERKLYSGAQTDGKFLLRPR-KEQGTYALSLIYGKTVYHYLISQDKAGKY 221 W+H L+ +AE L G FL RP K QG ++LS+ G V H I Q+ Y Sbjct: 4 WFHRDLSGLDAETLLKGRG-VHGSFLARPSRKNQGDFSLSVRVGDQVTHIRI-QNSGDFY 61 Query: 222 CIPEGTKFDTLWQLVEYLKLK------ADGLIYCLKEACPNS 257 + G KF TL +LVEY + DG I LK S Sbjct: 62 DLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCS 103 >3PS5-A nrPDB Length = 595 Score = 132 bits (332), Expect = 4e-31, Method: Composition-based stats. Identities = 57/264 (21%), Positives = 96/264 (36%), Gaps = 75/264 (28%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69 +F+ +S +AE LK G G FL R ++ G + LS+ + H I+ + Y Sbjct: 4 WFHRDLSGLDAETLLKGRG-VHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGD-FY 61 Query: 70 AIAGGKAHCGPAELCEFYS------RDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAMV 123 + GG+ EL E+Y+ +D DG +L+ P N Sbjct: 62 DLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLN-------------------- 101 Query: 124 RDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQT 183 + ER WYH ++ +AE L + + Sbjct: 102 -----------------------------CSDPTSER--WYHGHMSGGQAETLLQAKGEP 130 Query: 184 DGKFLLRPR-KEQGTYALSLIYGK---------TVYHYLISQDKAGKYCIPEGTKFDTLW 233 FL+R + G + LS++ + V H + + G+Y + FD+L Sbjct: 131 -WTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCE-GGRYTVGGLETFDSLT 188 Query: 234 QLVEYLKL----KADGLIYCLKEA 253 LVE+ K +A G L++ Sbjct: 189 DLVEHFKKTGIEEASGAFVYLRQP 212 Score = 85.1 bits (209), Expect = 8e-17, Method: Composition-based stats. Identities = 37/102 (36%), Positives = 47/102 (46%), Gaps = 9/102 (8%) Query: 163 WYHSSLTREEAERKLYSGAQTDGKFLLRPR-KEQGTYALSLIYGKTVYHYLISQDKAGKY 221 W+H L+ +AE L G FL RP K QG ++LS+ G V H I Q+ Y Sbjct: 4 WFHRDLSGLDAETLLKGRG-VHGSFLARPSRKNQGDFSLSVRVGDQVTHIRI-QNSGDFY 61 Query: 222 CIPEGTKFDTLWQLVEYLKLK------ADGLIYCLKEACPNS 257 + G KF TL +LVEY + DG I LK S Sbjct: 62 DLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCS 103 >2PMN-X nrPDB Length = 348 Score = 131 bits (330), Expect = 8e-31, Method: Composition-based stats. Identities = 46/215 (21%), Positives = 89/215 (41%), Gaps = 19/215 (8%) Query: 372 KQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQA-EALMLVMEMAGGGPLHKF----- 425 + + K+ ++ E QI+ + N Y + G+ + + ++ E + KF Sbjct: 79 DKISIKSKYDDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFF 138 Query: 426 LVGKREEI--PVSNVAELLHQVSMGMKYLE-EKNFVHRDLAARNVLLVNRHYAKISDFGL 482 ++ K P+ + ++ V Y+ EKN HRD+ N+L+ K+SDFG Sbjct: 139 VLDKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGE 198 Query: 483 SKALGADDSYYTARSAGKWPLKWYAPECI-NFRKF-SSRSDVWSYGVTMWEALSYGQKPY 540 S+ + + ++ PE N + ++ D+WS G+ ++ Y P+ Sbjct: 199 SEYMVD-----KKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMF-YNVVPF 252 Query: 541 K-KMKGPEVMAFIEQGKRMECPPECPPELYALMSD 574 K+ E+ I K +E P + LY L + Sbjct: 253 SLKISLVELFNNIRT-KNIEYPLDRNHFLYPLTNK 286 >2ABL-A nrPDB Length = 163 Score = 131 bits (329), Expect = 1e-30, Method: Composition-based stats. Identities = 37/102 (36%), Positives = 53/102 (51%), Gaps = 3/102 (2%) Query: 155 TTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSLIYGKTVYHYLI 213 + E+ WYH ++R AE L SG +G FL+R + G ++SL Y VYHY I Sbjct: 64 VNSLEKHSWYHGPVSRNAAEYLLSSG--INGSFLVRESESSPGQRSISLRYEGRVYHYRI 121 Query: 214 SQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACP 255 + GK + ++F+TL +LV + ADGLI L P Sbjct: 122 NTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAP 163 Score = 112 bits (279), Expect = 6e-25, Method: Composition-based stats. Identities = 28/93 (30%), Positives = 47/93 (50%), Gaps = 2/93 (2%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69 +++G +SR A E+L +G+ +G FL+R+ S G +SL ++ R +H+ I +G Sbjct: 72 WYHGPVSR-NAAEYLLSSGI-NGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKL 129 Query: 70 AIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPC 102 ++ AEL +S DGL L P Sbjct: 130 YVSSESRFNTLAELVHHHSTVADGLITTLHYPA 162 >3LLT-A nrPDB Length = 360 Score = 130 bits (328), Expect = 1e-30, Method: Composition-based stats. Identities = 52/271 (19%), Positives = 103/271 (38%), Gaps = 46/271 (16%) Query: 317 SPYSDPEELKDKKLF--LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG 374 + +E+ + +N + ++G G FG V + KK A+KV++ Sbjct: 14 LYFQGDDEIVHFSWKKGMLLNNAFLVIRKMGDGTFGRVLLCQHIDNKK--YYAVKVVRNI 71 Query: 375 TEKADTEEMMREAQIMHQLDNPYI-----VRLIGVC-QAEALMLVMEMAGGGPLHKFL-V 427 K T EA I+ ++ N I V+ G + + L+ E G L++ + Sbjct: 72 --KKYTRSAKIEADILKKIQNDDINNNNIVKYHGKFMYYDHMCLIFE-PLGPSLYEIITR 128 Query: 428 GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHY------------- 474 + ++ ++ + YL + + H DL N+LL + ++ Sbjct: 129 NNYNGFHIEDIKLYCIEILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDG 188 Query: 475 ------------AKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDV 522 K+ DFG + Y+ + + ++ APE I + SD+ Sbjct: 189 KKIQIYRTKSTGIKLIDFGCA---TFKSDYHGSIINTR---QYRAPEVILNLGWDVSSDM 242 Query: 523 WSYGVTMWEALSYGQKPYKKMKGPEVMAFIE 553 WS+G + E + G ++ + E +A +E Sbjct: 243 WSFGCVLAELYT-GSLLFRTHEHMEHLAMME 272 >2AUG-A nrPDB Length = 126 Score = 129 bits (325), Expect = 3e-30, Method: Composition-based stats. Identities = 32/100 (32%), Positives = 49/100 (49%), Gaps = 4/100 (4%) Query: 9 PFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHF---PIERQL 65 P+F+ ISR EA+ + G+ DG+FL+R + +VLS+ H + HF P+E Sbjct: 27 PWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVEDDG 86 Query: 66 NGTYAIAGGKA-HCGPAELCEFYSRDPDGLPCNLRKPCNR 104 + + G +L EFY + LPC L+ C R Sbjct: 87 EMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCAR 126 Score = 115 bits (287), Expect = 8e-26, Method: Composition-based stats. Identities = 34/106 (32%), Positives = 56/106 (52%), Gaps = 7/106 (6%) Query: 157 AHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYHYLI-- 213 H PW+H ++R+EA+R + DG FL+R + T+ LS+ +G+ + H+ I Sbjct: 22 IHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIP 81 Query: 214 -SQDKAGKYCIPEG-TKFDTLWQLVEYLKLKADGLIYC-LKEACPN 256 D + + +G T+F L QLVE+ +L G++ C LK C Sbjct: 82 VEDDGEMFHTLDDGHTRFTDLIQLVEFYQLN-KGVLPCKLKHYCAR 126 >5L2Q-C nrPDB Length = 320 Score = 128 bits (322), Expect = 6e-30, Method: Composition-based stats. Identities = 53/292 (18%), Positives = 108/292 (36%), Gaps = 50/292 (17%) Query: 352 VRQGVYRMRKKQIDVAIKVL------KQGTEKADTEE----MMREAQIMHQLD-NPYIVR 400 + Q + R +K+L QG E + + + E ++ L +V Sbjct: 30 IVQCLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVH 89 Query: 401 LIGVCQA-------------------EALMLVME-MAGGG---------PLHKFLVGKRE 431 G+ Q + + LV++ + L +++ K + Sbjct: 90 HHGLFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVI-KEK 148 Query: 432 EIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHY-AKISDFGLSKALGADD 490 + + + V ++ L +KN VHRDL N++L R + I++F L K L ++ Sbjct: 149 RLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEG 208 Query: 491 SYYTARSAGKWPLKWYAPECINFRKF-SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVM 549 + + + +P+ ++ R + SD+W+ GV ++ L YGQ P+ E+ Sbjct: 209 DLLKDQ---RGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTML-YGQFPFYDSIPQELF 264 Query: 550 AFIEQGKRMECPPE--CPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYS 599 I+ + P + L+ + + R V + + A S Sbjct: 265 RKIKAAEY-TIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLEALSAIIAS 315 >5U06-A nrPDB Length = 120 Score = 127 bits (320), Expect = 1e-29, Method: Composition-based stats. Identities = 34/99 (34%), Positives = 54/99 (54%), Gaps = 4/99 (4%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHF---PIERQLN 66 +F+G ISR E++ + G+ DGLFL+R+ R+ G+VLSL H + H+ P E + Sbjct: 19 WFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEEEGR 78 Query: 67 GTYAIAGGKA-HCGPAELCEFYSRDPDGLPCNLRKPCNR 104 +++ G+ +L EF+ + LPC LR C R Sbjct: 79 LYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTR 117 Score = 120 bits (300), Expect = 2e-27, Method: Composition-based stats. Identities = 34/114 (29%), Positives = 56/114 (49%), Gaps = 6/114 (5%) Query: 146 APQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRK-EQGTYALSLIY 204 +P ++ H W+H ++REE++R + DG FL+R + + LSL + Sbjct: 2 SPASGTSLSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCH 61 Query: 205 GKTVYHYLI-SQDKAGKYCI---PEGTKFDTLWQLVEYLKLKADGLIYCLKEAC 254 + V HYLI ++ G+ T+F L QLVE+ +L G++ CL C Sbjct: 62 LQKVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNR-GILPCLLRHC 114 >4XHL-A nrPDB Length = 394 Score = 127 bits (320), Expect = 1e-29, Method: Composition-based stats. Identities = 47/277 (16%), Positives = 106/277 (38%), Gaps = 23/277 (8%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 ++G G+FG + G + +++ ++ + ++ ++ E+++ L + I Sbjct: 14 KIGSGSFGDIYHGTNLISGEEVA-----IRLESIRSRHPQLDYESRVYRYLSGGVGIPFI 68 Query: 403 GVCQAEALM--LVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 E +V+++ G L V L Q+ ++Y+ ++F+HR Sbjct: 69 RWFGREGEYNAMVIDLL-GPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQYIHGRSFIHR 127 Query: 461 DLAARNVLLV---NRHYAKISDFGLSKALGADDSY----YTARSAGKWPLKWYAPECINF 513 D+ N L+ + DFGLSK +++ Y + ++ + Sbjct: 128 DIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTHLG 187 Query: 514 RKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQG--KRMECP-----PECPP 566 + S R D+ S G + G P++ +K ++ K++ P Sbjct: 188 IEQSRRDDLESLGYVLIY-FCKGSLPWQGLKATTKKQKYDRIMEKKLNVSVETLCSGLPL 246 Query: 567 ELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASK 603 E M+ C K++++PD+L + + + L Sbjct: 247 EFQEYMAYCKNLKFDEKPDYLFLARLFKDLSIKLEYH 283 >4MD7-E nrPDB Length = 391 Score = 127 bits (319), Expect = 1e-29, Method: Composition-based stats. Identities = 44/285 (15%), Positives = 104/285 (36%), Gaps = 36/285 (12%) Query: 334 RDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL 393 +D+ + +LG G + V + + +++ + + +++ RE +I+ L Sbjct: 36 QDDYQLVR-KLGRGKYSEVFEAINITNNEKVV------VKILKPVKKKKIKREIKILENL 88 Query: 394 DN-PYIVRLIGVCQAE---ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGM 449 P I+ L + + LV E + + + ++ ++++ + Sbjct: 89 RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL----YQTLTDYDIRFYMYEILKAL 144 Query: 450 KYLEEKNFVHRDLAARNVLLVNRHY-AKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 Y +HRD+ NV++ + H ++ D+GL+ Y R A ++ P Sbjct: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKG---P 200 Query: 509 ECI-NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPE 567 E + +++ + D+WS G + + + + + + I + + Sbjct: 201 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG-------TED 253 Query: 568 LYALMSDCWIYKWEDRPDFLTV-----EQRMRACYYSLASKVEGP 607 LY + Y E P F + +R +S + P Sbjct: 254 LYDYID---KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSP 295 >4BTK-A nrPDB Length = 337 Score = 127 bits (319), Expect = 2e-29, Method: Composition-based stats. Identities = 48/265 (18%), Positives = 103/265 (38%), Gaps = 18/265 (6%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN-PYIVR 400 ++G G FG + + + + ++ VA+KV + + + + E ++ +L ++ R Sbjct: 62 KKIGGGGFGEIYEAMDLLTREN--VALKV---ESAQQPKQVLKMEVAVLKKLQGKDHVCR 116 Query: 401 LIGVCQAEAL-MLVMEMAGGGPLHKFLVGK-REEIPVSNVAELLHQVSMGMKYLEEKNFV 458 IG + E +VM++ G L + R +S L Q+ ++ + F+ Sbjct: 117 FIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFL 175 Query: 459 HRDLAARNV----LLVNRHYAKISDFGLSKALGADDSYYTAR---SAGKWPLKWYAPECI 511 HRD+ N L + DFGL++ + + +++ + Sbjct: 176 HRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAH 235 Query: 512 NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRME-CPPECPPELYA 570 R+ D+WS + E + GQ P++K+K E + I++ P E + Sbjct: 236 KNREMGRHDDLWSLFYMLVE-FAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHL 294 Query: 571 LMSDCWIYKWEDRPDFLTVEQRMRA 595 + + +PD+ + Sbjct: 295 FLDHIASLDYFTKPDYQLIMSVFEN 319 >2CMW-A nrPDB Length = 310 Score = 126 bits (317), Expect = 3e-29, Method: Composition-based stats. Identities = 57/278 (20%), Positives = 105/278 (37%), Gaps = 28/278 (10%) Query: 341 DIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN--PYI 398 ++GCGNFG +R G + VAIK+ K+ ++ E + QL + + Sbjct: 5 GKKIGCGNFGELRLG--KNLYTNEYVAIKL---EPIKSRAPQLHLEYRFYKQLGSAGEGL 59 Query: 399 --VRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKN 456 V G C + +V+E+ G L + V + Q+ M+Y+ KN Sbjct: 60 PQVYYFGPC-GKYNAMVLELL-GPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKN 117 Query: 457 FVHRDLAARNVLLVNRHYAK-----ISDFGLSKALGADDSY----YTARSAGKWPLKWYA 507 ++RD+ N L+ + K I DFGL+K ++ Y + ++ + Sbjct: 118 LIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMS 177 Query: 508 PECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKG---PEVMAFIEQGKRMECP--- 561 ++ S R D+ + G M+ G P++ +K E I KR Sbjct: 178 INTHLGKEQSRRDDLEALG-HMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEAL 236 Query: 562 -PECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYY 598 P E+ + + ++PD+ + + Sbjct: 237 CENFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLFE 274 >4NFN-A nrPDB Length = 309 Score = 126 bits (316), Expect = 3e-29, Method: Composition-based stats. Identities = 48/265 (18%), Positives = 103/265 (38%), Gaps = 18/265 (6%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN-PYIVR 400 ++G G FG + + + + ++ VA+KV + + + + E ++ +L ++ R Sbjct: 27 KKIGGGGFGEIYEAMDLLTREN--VALKV---ESAQQPKQVLKMEVAVLKKLQGKDHVCR 81 Query: 401 LIGVCQAEAL-MLVMEMAGGGPLHKFLVGK-REEIPVSNVAELLHQVSMGMKYLEEKNFV 458 IG + E +VM++ G L + R +S L Q+ ++ + F+ Sbjct: 82 FIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFL 140 Query: 459 HRDLAARNV----LLVNRHYAKISDFGLSKALGADDSYYTAR---SAGKWPLKWYAPECI 511 HRD+ N L + DFGL++ + + +++ + Sbjct: 141 HRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAH 200 Query: 512 NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRME-CPPECPPELYA 570 R+ D+WS + E + GQ P++K+K E + I++ P E + Sbjct: 201 KNREMGRHDDLWSLFYMLVE-FAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHL 259 Query: 571 LMSDCWIYKWEDRPDFLTVEQRMRA 595 + + +PD+ + Sbjct: 260 FLDHIASLDYFTKPDYQLIMSVFEN 284 >1NRV-A nrPDB Length = 105 Score = 126 bits (316), Expect = 3e-29, Method: Composition-based stats. Identities = 32/99 (32%), Positives = 49/99 (49%), Gaps = 4/99 (4%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHF---PIERQLN 66 +F+G ISR E+ +K G+ DGLFLLR + +VL+L H + +F P E Sbjct: 7 WFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILPCEDDGQ 66 Query: 67 GTYAIAGGKA-HCGPAELCEFYSRDPDGLPCNLRKPCNR 104 +++ G +L +FY + LPC L+ C R Sbjct: 67 TFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIR 105 Score = 111 bits (278), Expect = 8e-25, Method: Composition-based stats. Identities = 31/104 (29%), Positives = 52/104 (50%), Gaps = 7/104 (6%) Query: 157 AHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYHYLI-- 213 H W+H ++REE+ R + DG FLLR + + L+L + + + ++ I Sbjct: 1 IHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQKIKNFQILP 60 Query: 214 -SQDKAGKYCIPEG-TKFDTLWQLVEYLKLKADGLIYC-LKEAC 254 D + + +G TKF L QLV++ +L G++ C LK C Sbjct: 61 CEDDGQTFFSLDDGNTKFSDLIQLVDFYQLN-KGVLPCKLKHHC 103 >5X18-A nrPDB Length = 295 Score = 126 bits (316), Expect = 4e-29, Method: Composition-based stats. Identities = 50/286 (17%), Positives = 104/286 (36%), Gaps = 27/286 (9%) Query: 341 DIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN-PYIV 399 ++G G+FG + +G + + VAIK K + ++ E + L+ P I Sbjct: 12 GKKIGEGSFGVLFEGTNMING--VPVAIKF---EPRKTEAPQLRDEYKTYKILNGTPNI- 65 Query: 400 RLIGVCQAEALM--LVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNF 457 E L LV+++ G L + V V ++ Q+ ++ L + Sbjct: 66 PYAYYFGQEGLHNILVIDLL-GPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHAHDL 124 Query: 458 VHRDLAARNVLLVNRHY-----AKISDFGLSKALGADDSY----YTARSAGKWPLKWYAP 508 ++RD+ N L+ + DFG++K + Y + + ++ + Sbjct: 125 IYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYMSI 184 Query: 509 ECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKM---KGPEVMAFIEQGKR----MECP 561 R+ S R D+ + G + L G P++ + + I + KR + Sbjct: 185 NTHLGREQSRRDDMEALGHVFFYFL-RGHLPWQGLKAPNNKQKYEKIGEKKRSTNVYDLA 243 Query: 562 PECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGP 607 P + + +E+ PD+ + + + L +G Sbjct: 244 QGLPVQFGRYLEIVRSLSFEECPDYEGYRKLLLSVLDDLGETADGQ 289 >5XVU-A nrPDB Length = 332 Score = 125 bits (315), Expect = 4e-29, Method: Composition-based stats. Identities = 32/219 (14%), Positives = 82/219 (37%), Gaps = 20/219 (9%) Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN-PYIVR 400 ++G G + V G + + + +++ RE +I+ L+ P I++ Sbjct: 37 KKIGRGKYSEVFNGYDTECNRPCA------IKVLKPVKKKKIKREIKILQNLNGGPNIIK 90 Query: 401 LIGVCQA---EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNF 457 L+ + + + L+ E + ++ ++Q+ + Y + Sbjct: 91 LLDIVKDPVTKTPSLIFEYINNIDFKTL----YPKFTDKDIRYYIYQILKALDYCHSQGI 146 Query: 458 VHRDLAARNVLLV-NRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPE-CINFRK 515 +HRD+ N+++ ++ +GL+ Y R A ++ + PE I+ + Sbjct: 147 MHRDVKPHNIMIDHENRQIRLISWGLA-EFYHPGQEYNVRVASRY---YKGPELLIDLQL 202 Query: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 554 + D+WS G + + + + + + I + Sbjct: 203 YDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAK 241 >4L68-A nrPDB Length = 340 Score = 125 bits (315), Expect = 4e-29, Method: Composition-based stats. Identities = 50/266 (18%), Positives = 100/266 (37%), Gaps = 25/266 (9%) Query: 350 GSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC--QA 407 G+ + + +A+K L T K E E + +L + + L+G C + Sbjct: 54 GTTYKALL---PDGSALAVKHLS--TCKLGEREFRYEMNQLWELRHSNLAPLLGFCVVEE 108 Query: 408 EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE---KNFVHRDLAA 464 E LV + G LH L R E+ S + + G+ +L +H+++ + Sbjct: 109 EKF-LVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICS 167 Query: 465 RNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGK-WPLKWYAPECINFRKFSSRSDVW 523 +L+ A+I D GL++ + D+ ++ G + APE S + DV+ Sbjct: 168 SVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEYSTTMLASLKGDVY 227 Query: 524 SYGVTMWEALS----YGQKPYKK---------MKGPEVMAFIEQGKRMECPPECPPELYA 570 GV + E + G + +K + ++ R + E + Sbjct: 228 GLGVVLLELATGLKAVGGEGFKGSLVDWVKQLESSGRIAETFDENIRGKGHDEEISKFVE 287 Query: 571 LMSDCWIYKWEDRPDFLTVEQRMRAC 596 + +C + ++R Q ++A Sbjct: 288 IALNCVSSRPKERWSMFQAYQSLKAI 313 >6EII-A nrPDB Length = 352 Score = 125 bits (315), Expect = 4e-29, Method: Composition-based stats. Identities = 44/285 (15%), Positives = 104/285 (36%), Gaps = 36/285 (12%) Query: 334 RDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL 393 +D+ + +LG G + V + + +++ + + +++ RE +I+ L Sbjct: 59 QDDYQLVR-KLGRGKYSEVFEAINITNNEKVV------VKILKPVKKKKIKREIKILENL 111 Query: 394 DN-PYIVRLIGVCQAE---ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGM 449 P I+ L + + LV E + + + ++ ++++ + Sbjct: 112 RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQL----YQTLTDYDIRFYMYEILKAL 167 Query: 450 KYLEEKNFVHRDLAARNVLLVNRHY-AKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 Y +HRD+ NV++ + H ++ D+GL+ Y R A ++ P Sbjct: 168 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKG---P 223 Query: 509 ECI-NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPE 567 E + +++ + D+WS G + + + + + + I + + Sbjct: 224 ELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLG-------TED 276 Query: 568 LYALMSDCWIYKWEDRPDFLTV-----EQRMRACYYSLASKVEGP 607 LY + Y E P F + +R +S + P Sbjct: 277 LYDYID---KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSP 318 >2PVN-A nrPDB Length = 352 Score = 125 bits (315), Expect = 4e-29, Method: Composition-based stats. Identities = 35/228 (15%), Positives = 90/228 (39%), Gaps = 21/228 (9%) Query: 333 KRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQ 392 ++D+ + ++G G + V +G+ + K + + + +++ RE +I+ Sbjct: 50 EQDDYEVVR-KVGRGKYSEVFEGINVNNNE------KCIIKILKPVKKKKIKREIKILQN 102 Query: 393 L-DNPYIVRLIGVC---QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMG 448 L P IV+L+ + ++ L+ E + ++ ++++ Sbjct: 103 LCGGPNIVKLLDIVRDQHSKTPSLIFEYVNNTDFKVL----YPTLTDYDIRYYIYELLKA 158 Query: 449 MKYLEEKNFVHRDLAARNVLLVNRHY-AKISDFGLSKALGADDSYYTARSAGKWPLKWYA 507 + Y + +HRD+ NV++ + ++ D+GL+ Y R A ++ Sbjct: 159 LDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLA-EFYHPGKEYNVRVASRYFKG--- 214 Query: 508 PECI-NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQ 554 PE + + + + D+WS G + + + + + I + Sbjct: 215 PELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAK 262 >4NT4-A nrPDB Length = 312 Score = 123 bits (310), Expect = 2e-28, Method: Composition-based stats. Identities = 56/282 (19%), Positives = 103/282 (36%), Gaps = 33/282 (11%) Query: 341 DIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL-DN---- 395 ++GCGNFG +R G + VAIK+ K+ ++ E + L + Sbjct: 17 GKKIGCGNFGELRLG--KNLYNNEHVAIKM---EPMKSKAPQLHLEYRFYKLLGSHADNA 71 Query: 396 ----PYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKY 451 P I L G C +V+E+ G L + + V + Q+ ++Y Sbjct: 72 PDGIPRIYHL-GTCGGRYNAMVLELL-GLSLEDLFNICARKFSLKTVLMIAKQLLHRIEY 129 Query: 452 LEEKNFVHRDLAARNVLLVNRHY-----AKISDFGLSKALGADDSY----YTARSAGKWP 502 + ++ ++RD+ N L+ I DFGL+K D+ Y + Sbjct: 130 VHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGT 189 Query: 503 LKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKG---PEVMAFIEQGKRME 559 ++ + R+ S R D+ + G M+ G P++ +K E I KR Sbjct: 190 ARYMSINTHMGREQSRRDDLEALG-HMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRAT 248 Query: 560 CP----PECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACY 597 P E + + + PD+ + + + + Sbjct: 249 PIEVLCDGHPEEFATYLRYVRRLDFFETPDYDFLRRLFQDLF 290 >4WUA-A nrPDB Length = 401 Score = 123 bits (308), Expect = 3e-28, Method: Composition-based stats. Identities = 49/268 (18%), Positives = 98/268 (36%), Gaps = 74/268 (27%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN-----PY 397 +LG G+F +V KK VA+KV+K + + TE + E +++ + N P Sbjct: 48 KLGWGHFSTVWLSWDIQGKK--FVAMKVVK--SAEHYTETALDEIRLLKSVRNSDPNDPN 103 Query: 398 ---IVRLIGVCQ-----AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGM 449 +V+L+ + + +V E+ G L + + +P+ V +++ QV G+ Sbjct: 104 REMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGL 163 Query: 450 KYLEEK-NFVHRDLAARNVLLV-------------------------------------- 470 YL K +H D+ N+LL Sbjct: 164 DYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPATAGN 223 Query: 471 -----------NRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 519 + KI+D G + + + + ++ + E + +++ Sbjct: 224 FLVNPLEPKNAEKLKVKIADLGNACWV------HKHFTEDIQTRQYRSLEVLIGSGYNTP 277 Query: 520 SDVWSYGVTMWEALSYGQKPYKKMKGPE 547 +D+WS +E L+ G ++ G E Sbjct: 278 ADIWSTACMAFE-LATGDYLFEPHSGEE 304 >2JD5-A nrPDB Length = 373 Score = 123 bits (308), Expect = 3e-28, Method: Composition-based stats. Identities = 46/235 (19%), Positives = 103/235 (43%), Gaps = 34/235 (14%) Query: 334 RDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL 393 +D I +LG G+F +V + VA+K+++ +K TE E +++ ++ Sbjct: 17 KDARYILVRKLGWGHFSTVWLAKDMVNNTH--VAMKIVR--GDKVYTEAAEDEIKLLQRV 72 Query: 394 DNP-----------YIVRLIGVCQAEA-----LMLVMEMAGGGPLHKFLVGKREEIPVSN 437 ++ +I++L+ + +++V E+ G L + IP+ Sbjct: 73 NDADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIY 132 Query: 438 VAELLHQVSMGMKYLEEK-NFVHRDLAARNVL---LVNRH---YAKISDFGLSKALGADD 490 V ++ Q+ +G+ Y+ + +H D+ NVL + + KI+D G + D Sbjct: 133 VKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWY---D 189 Query: 491 SYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKG 545 +YT + ++ +PE + + +D+WS ++E ++ G ++ +G Sbjct: 190 EHYTNSIQTR---EYRSPEVLLGAPWGCGADIWSTACLIFELIT-GDFLFEPDEG 240 >6HMD-A nrPDB Length = 365 Score = 122 bits (306), Expect = 5e-28, Method: Composition-based stats. Identities = 44/285 (15%), Positives = 106/285 (37%), Gaps = 36/285 (12%) Query: 334 RDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL 393 +D+ + +LG G + V + + +++ + + +++ RE +I+ L Sbjct: 52 QDDYQLVR-KLGRGKYSEVFEAINITNNERVV------VKILKPVKKKKIKREVKILENL 104 Query: 394 DNP-YIVRLIGVCQA---EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGM 449 I++LI + + LV E + + + ++ ++++ + Sbjct: 105 RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQL----YQILTDFDIRFYMYELLKAL 160 Query: 450 KYLEEKNFVHRDLAARNVLLVN-RHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAP 508 Y K +HRD+ NV++ + + ++ D+GL+ Y R A ++ P Sbjct: 161 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKG---P 216 Query: 509 ECI-NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPE 567 E + +++ + D+WS G + + + + + + I + E Sbjct: 217 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG-------TEE 269 Query: 568 LYALMSDCWIYKWEDRPDFLTV-----EQRMRACYYSLASKVEGP 607 LY + Y + P F + +R +S + P Sbjct: 270 LYGYLK---KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSP 311 >2X7G-A nrPDB Length = 389 Score = 122 bits (305), Expect = 5e-28, Method: Composition-based stats. Identities = 49/266 (18%), Positives = 101/266 (37%), Gaps = 72/266 (27%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD-----NPY 397 +LG G+F +V + M+ K+ VA+KV+K + + TE + E +++ + +P Sbjct: 38 KLGWGHFSTVWLC-WDMQGKRF-VAMKVVK--SAQHYTETALDEIKLLKCVRESDPSDPN 93 Query: 398 ---IVRLIGVCQAEA-----LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGM 449 +V+LI + + +V E+ G L + + +PV V ++ QV G+ Sbjct: 94 KDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGL 153 Query: 450 KYLEEK-NFVHRDLAARNVLL--------------------------------------- 469 YL K +H D+ N+L+ Sbjct: 154 DYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPAADLL 213 Query: 470 --------VNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSD 521 ++ KI+D G + + + + ++ + E + +S+ +D Sbjct: 214 VNPLDPRNADKIRVKIADLGNACWV------HKHFTEDIQTRQYRSIEVLIGAGYSTPAD 267 Query: 522 VWSYGVTMWEALSYGQKPYKKMKGPE 547 +WS +E L+ G ++ G + Sbjct: 268 IWSTACMAFE-LATGDYLFEPHSGED 292 >2C47-A nrPDB Length = 313 Score = 122 bits (305), Expect = 6e-28, Method: Composition-based stats. Identities = 53/275 (19%), Positives = 101/275 (36%), Gaps = 25/275 (9%) Query: 341 DIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVR 400 ++GCGNFG +R G + VAIK+ K+ ++ E + QL V Sbjct: 9 GKKIGCGNFGELRLG--KNLYTNEYVAIKL---EPIKSRAPQLHLEYRFYKQLSATEGVP 63 Query: 401 LIGVCQ--AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 + + +V+E+ G L + V + Q+ M+Y+ K+ + Sbjct: 64 QVYYFGPCGKYNAMVLELL-GPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLI 122 Query: 459 HRDLAARNVLLVNRHY-----AKISDFGLSKALGADDSY----YTARSAGKWPLKWYAPE 509 +RD+ N L+ I DFGL+K ++ Y + ++ + Sbjct: 123 YRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSIN 182 Query: 510 CINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKG---PEVMAFIEQGKRMECP----P 562 ++ S R D+ + G M+ G P++ +K E I KR Sbjct: 183 THLGKEQSRRDDLEALG-HMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCE 241 Query: 563 ECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACY 597 P E+ + + ++PD+ + + + Sbjct: 242 NFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLF 276 >2CHL-A nrPDB Length = 351 Score = 120 bits (302), Expect = 1e-27, Method: Composition-based stats. Identities = 57/275 (20%), Positives = 104/275 (37%), Gaps = 26/275 (9%) Query: 341 DIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN-PYI- 398 ++GCGNFG +R G + VAIK+ K+ ++ E + QL + I Sbjct: 35 GKKIGCGNFGELRLG--KNLYTNEYVAIKL---EPMKSRAPQLHLEYRFYKQLGSGDGIP 89 Query: 399 -VRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNF 457 V G C + +V+E+ G L + V + Q+ M+Y+ KN Sbjct: 90 QVYYFGPC-GKYNAMVLELL-GPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNL 147 Query: 458 VHRDLAARNVLLVNRHY-----AKISDFGLSKALGADDSY----YTARSAGKWPLKWYAP 508 ++RD+ N L+ I DF L+K ++ Y + ++ + Sbjct: 148 IYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSI 207 Query: 509 ECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKG---PEVMAFIEQGKR-MECPPEC 564 ++ S R D+ + G M+ G P++ +K E I KR C Sbjct: 208 NTHLGKEQSRRDDLEALG-HMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLC 266 Query: 565 P--PELYALMSDCWIYKWEDRPDFLTVEQRMRACY 597 PE+ + + ++PD+ + + + Sbjct: 267 ENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLF 301 >4F9B-A nrPDB Length = 361 Score = 120 bits (300), Expect = 2e-27, Method: Composition-based stats. Identities = 41/243 (16%), Positives = 79/243 (32%), Gaps = 42/243 (17%) Query: 336 NLLIADIELGCGNFGSVRQGVYRMR-KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD 394 N+ + ++G G F SV +++ + +A+K L + + E Q + Sbjct: 21 NVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPI---RIAAELQCLTVAG 77 Query: 395 N-PYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYL 452 ++ + + + +++ M L V E + + +K + Sbjct: 78 GQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSF----QEVREYMLNLFKALKRI 133 Query: 453 EEKNFVHRDLAARNVLLVNRHYAK---ISDFGLSKALGADDSYYTARSAGK--------- 500 + VHRD+ N L R K + DFGL++ + Sbjct: 134 HQFGIVHRDVKPSNFLYNRR--LKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQN 191 Query: 501 ----------------WPLKWYAPECINFRK-FSSRSDVWSYGVTMWEALSYGQKPYKKM 543 + APE + ++ D+WS GV LS G+ P+ K Sbjct: 192 KCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLS-GRYPFYKA 250 Query: 544 KGP 546 Sbjct: 251 SDD 253 >4I94-A nrPDB Length = 300 Score = 120 bits (300), Expect = 3e-27, Method: Composition-based stats. Identities = 55/258 (21%), Positives = 106/258 (41%), Gaps = 18/258 (6%) Query: 351 SVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEA 409 V +G + Q +A+K + + D+ + + EA+ + QL N + L+G C + E Sbjct: 44 VVYKGKL---ENQRRIAVKRFNRKSWP-DSRQFLEEAKAVGQLRNHRMANLLGCCYEDEE 99 Query: 410 LMLVMEMAGGGPLHKFLVG-KREEIPVSNVAELLHQVSMGMKYLEEKN-FVHRDLAARNV 467 +L+ E L K L + + + + + ++ ++Y K ++ DL A V Sbjct: 100 RLLIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYRV 159 Query: 468 LLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGV 527 L + ++S FGL K SY T L + PE + + + S ++S+G Sbjct: 160 LFDDDANPRLSCFGLMKNSRDGKSYSTN-------LAFTPPEYLRTGRVTPESVIYSFGT 212 Query: 528 TMWEALSYGQKPYKK----MKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDR 583 + + LS P ++ + ++ G + + EL L S C Y+ +R Sbjct: 213 LLLDLLSGKHIPPSHALDLIRDRNIQMLMDSGLEGQFSSDDGTELIRLASRCLQYEPRER 272 Query: 584 PDFLTVEQRMRACYYSLA 601 P+ ++ M L Sbjct: 273 PNPKSLVSAMIPLQKDLE 290 >1CSN-A nrPDB Length = 298 Score = 118 bits (297), Expect = 5e-27, Method: Composition-based stats. Identities = 55/284 (19%), Positives = 107/284 (37%), Gaps = 29/284 (10%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN-PYIVRLI 402 +G G+FG + +G + +Q VAIK + ++ + R +++ P + Sbjct: 18 IGEGSFGVIFEGTNLLNNQQ--VAIKFEPRRSDAPQLRDEYRTYKLLAGCTGIPNV---- 71 Query: 403 GVCQAEAL--MLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 E L +LV+++ G L L + V VA Q+ ++ + EK+ V+R Sbjct: 72 YYFGQEGLHNVLVIDLL-GPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHEKSLVYR 130 Query: 461 DLAARNVLL-----VNRHYAKISDFGLSKA----LGADDSYYTARSAGKWPLKWYAPECI 511 D+ N L+ N + + DFG+ K + Y + ++ + Sbjct: 131 DIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARYMSINTH 190 Query: 512 NFRKFSSRSDVWSYG-VTMWEALSYGQKPYKKM---KGPEVMAFIEQGKRM-ECPPEC-- 564 R+ S R D+ + G V M+ G P++ + + I + K+ C Sbjct: 191 LGREQSRRDDLEALGHVFMYFL--RGSLPWQGLKAATNKQKYERIGEKKQSTPLRELCAG 248 Query: 565 -PPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGP 607 P E Y M ++ PD+ ++ L + + Sbjct: 249 FPEEFYKYMHYARNLAFDATPDYDYLQGLFSKVLERLNTTEDEN 292 >6J6I-B nrPDB Length = 351 Score = 118 bits (295), Expect = 1e-26, Method: Composition-based stats. Identities = 53/288 (18%), Positives = 109/288 (37%), Gaps = 43/288 (14%) Query: 352 VRQGVYRMRKKQIDVAIKVLKQGT---EKADTEEMMREAQIMHQL-DNPYIVRLIGVC-Q 406 V YR + IK + ++ +E+ + + ++ ++ ++L+G C + Sbjct: 70 VYYKWYRGEIEDRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLE 129 Query: 407 AEALMLVMEMAGGGPLHK----FLVGKREEIPVSNVAELLHQVSMGMKYLEE---KNFVH 459 +LV E A G +++ + G+ +P S ++ +++ + YL K +H Sbjct: 130 FPFPVLVFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIH 189 Query: 460 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 519 RD+ +V L AK+SD S +L S A + P + Sbjct: 190 RDVKPMHVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWV-LGTFGYIDPLYHKTCFVTEY 248 Query: 520 SDVWSYGVTMWEALSYGQK------------------------PYKKMKGPEVMAFIEQG 555 +DV+S+G+ + ++ G+ ++ P +M I G Sbjct: 249 TDVYSFGICLLVIIT-GKPAIMTISDGDLQGILSLVRELCENGKLDEVIDPRLMKDITSG 307 Query: 556 KRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASK 603 +R++ L C + EDRP + V + ++ SL + Sbjct: 308 QRLQV-----EACVVLALRCCKERDEDRPKMIQVAKELKQIEASLKNS 350 >4LFI-A nrPDB Length = 374 Score = 115 bits (289), Expect = 4e-26, Method: Composition-based stats. Identities = 29/203 (14%), Positives = 71/203 (34%), Gaps = 24/203 (11%) Query: 392 QLDNPYIVRLIGVCQA---EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMG 448 + I+ L + + + LV E ++ + + ++ Sbjct: 129 HNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRIL----YPKLTDLEIRFYMFELLKA 184 Query: 449 MKYLEEKNFVHRDLAARNVLLVNRH-YAKISDFGLSKALGADDSYYTARSAGKWPLKWYA 507 + Y +HRD+ NV++ +++ ++ D+GL+ + Y R A ++ Sbjct: 185 LDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA-EFYHVNMEYNVRVASRFFKG--- 240 Query: 508 PECI-NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIE--------QGKRM 558 PE + ++R + D+WS+G + + + + + + I + + Sbjct: 241 PELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLL 300 Query: 559 ECPPECPPELY---ALMSDCWIY 578 + P E Y + W Sbjct: 301 KYEITLPREFYDMDQYIRKPWHR 323 >2EKX-A nrPDB Length = 110 Score = 115 bits (287), Expect = 7e-26, Method: Composition-based stats. Identities = 24/110 (21%), Positives = 51/110 (46%), Gaps = 7/110 (6%) Query: 151 KLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLI------Y 204 ++ + W+ +++R ++E+ L + +G F++R + G Y +SL Sbjct: 1 GSSGSSGLDDYDWFAGNISRSQSEQLLRQKGK-EGAFMVRNSSQVGMYTVSLFSKAVNDK 59 Query: 205 GKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEAC 254 TV HY + + K + E FD++ +L+ Y + + G+I L+ Sbjct: 60 KGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPV 109 Score = 71.6 bits (174), Expect = 1e-12, Method: Composition-based stats. Identities = 22/98 (22%), Positives = 42/98 (42%), Gaps = 8/98 (8%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSL------VHDVRFHHFPIER 63 +F G+ISR+++E+ L+ G +G F++R +G Y +SL H+ + Sbjct: 13 WFAGNISRSQSEQLLRQKG-KEGAFMVRNS-SQVGMYTVSLFSKAVNDKKGTVKHYHVHT 70 Query: 64 QLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKP 101 +A +L ++ + G+ LR P Sbjct: 71 NAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHP 108 >5X1R-A nrPDB Length = 302 Score = 115 bits (287), Expect = 8e-26, Method: Composition-based stats. Identities = 45/289 (15%), Positives = 101/289 (34%), Gaps = 39/289 (13%) Query: 334 RDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKV-----LKQGTE------------ 376 R N +G G FG V + + +AIK L + + Sbjct: 19 RFNEFEIQEAIGEGGFGIVYRAYDHQL--ERTIAIKEYMPTSLAKRNDDLSIGLRGERFG 76 Query: 377 ---KADTEEMMREAQIMHQLDNPYIVRLIGVCQAEAL-MLVMEMAGGGPLHKFLVGKREE 432 +A ++EA+++ + +P ++ ++ + + + G L + E+ Sbjct: 77 KTFQAGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQPEK 136 Query: 433 IPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSY 492 I + + LL + + + ++ ++HRD++ N+ + + DFG ++ + Sbjct: 137 IDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARK---EIGN 193 Query: 493 YTARSAGKWPLKWYAPECINFRKFSSR---SDVWSYGVTMWEALSYGQKPYKKMKGPEVM 549 + + + E + +D+++ G + + G P V+ Sbjct: 194 LSDETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLI-VGSPP-----PVSVV 247 Query: 550 AFIEQGKRM---ECPPECPPELYALMSDCWIYKWEDRP-DFLTVEQRMR 594 IE + P PEL + K EDRP + + + Sbjct: 248 RSIEDSYQPLTERRPAGYSPELLRTVDRALALKPEDRPQTIDEMAELLE 296 >2CRH-A nrPDB Length = 138 Score = 114 bits (285), Expect = 1e-25, Method: Composition-based stats. Identities = 35/110 (31%), Positives = 51/110 (46%), Gaps = 9/110 (8%) Query: 2 PDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPI 61 D + HL ++ G + RA AE L A +DG FL+RQ ++ + +S+ ++V H I Sbjct: 21 QDLSVHL-WYAGPMERAGAESIL--ANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKI 77 Query: 62 ERQLNGTYAIAGGKAHCGPAELCEFYSRDP-----DGLPCNLRKPCNRPS 106 G Y I KA G EL EFY ++ L L+ P P Sbjct: 78 -MTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPE 126 Score = 70.8 bits (172), Expect = 2e-12, Method: Composition-based stats. Identities = 28/85 (32%), Positives = 40/85 (47%), Gaps = 4/85 (4%) Query: 161 MPWYHSSLTREEAERKLYSGAQTDGKFLLRPR-KEQGTYALSLIYGKTVYHYLISQDKAG 219 WY + R AE L + + DG FL+R R K+ +A+S+ Y V H I G Sbjct: 26 HLWYAGPMERAGAESILANRS--DGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMT-AEG 82 Query: 220 KYCIPEGTKFDTLWQLVEYLKLKAD 244 Y I E F L +LVE+ + + Sbjct: 83 LYRITEKKAFRGLTELVEFYQQNSL 107 >2LCT-A nrPDB Length = 107 Score = 113 bits (282), Expect = 3e-25, Method: Composition-based stats. Identities = 35/109 (32%), Positives = 51/109 (46%), Gaps = 9/109 (8%) Query: 1 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP 60 M D + HL ++ G + RA AE L A +DG FL+RQ ++ + +S+ ++V H Sbjct: 3 MQDLSVHL-WYAGPMERAGAESIL--ANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIK 59 Query: 61 IERQLNGTYAIAGGKAHCGPAELCEFYSRDP-----DGLPCNLRKPCNR 104 I G Y I KA G EL EFY ++ L L+ P Sbjct: 60 I-MTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKE 107 Score = 70.4 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 28/85 (32%), Positives = 40/85 (47%), Gaps = 4/85 (4%) Query: 161 MPWYHSSLTREEAERKLYSGAQTDGKFLLRPR-KEQGTYALSLIYGKTVYHYLISQDKAG 219 WY + R AE L + + DG FL+R R K+ +A+S+ Y V H I G Sbjct: 9 HLWYAGPMERAGAESILANRS--DGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMT-AEG 65 Query: 220 KYCIPEGTKFDTLWQLVEYLKLKAD 244 Y I E F L +LVE+ + + Sbjct: 66 LYRITEKKAFRGLTELVEFYQQNSL 90 >5OAT-A nrPDB Length = 411 Score = 111 bits (278), Expect = 8e-25, Method: Composition-based stats. Identities = 54/317 (17%), Positives = 105/317 (33%), Gaps = 71/317 (22%) Query: 331 FLKRDNLLIADIELGC----GNFGSVRQGVYRMRKK---QIDVAIKVLKQGTEKADTEEM 383 + + + + D+ LG G G V + + + A+K++ + ++ E+ Sbjct: 2 RFESNPITLNDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEI 61 Query: 384 MR---------------------EAQIMHQLDN----PYIVRLIGVCQA----------- 407 ++ E ++ ++ + P IV + V Sbjct: 62 LKAMYRETVPARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLH 121 Query: 408 -------EALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHR 460 +L L+M+ L FL + L + G+ ++ HR Sbjct: 122 PEGEGRNMSLFLLMKRYDC-NLQSFLSTAPSTRTSLLLLAQLLE---GVAHMTAHGIAHR 177 Query: 461 DLAARNVLLV----NRHYAKISDFGLS---KALGADDSYYTARSAGKWPLKWYAPECINF 513 DL + N+LL ISDFG K G Y + APE I Sbjct: 178 DLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQ 237 Query: 514 RK-------FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPP 566 + +S ++D+W+ G +E + P+ + ++G + P E P Sbjct: 238 KPGTFSVLNYS-KADLWAVGAIAYEIFNC-HNPFYGPSRLKNFN-YKEGDLPKLPDEVPT 294 Query: 567 ELYALMSDCWIYKWEDR 583 + AL+++ R Sbjct: 295 VIQALVANLLKRNPNKR 311 >6DC0-A nrPDB Length = 292 Score = 111 bits (277), Expect = 1e-24, Method: Composition-based stats. Identities = 39/255 (15%), Positives = 90/255 (35%), Gaps = 20/255 (7%) Query: 352 VRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALM 411 V + + +++ + +K +K + + I ++ V E Sbjct: 22 VSRALCIHTGRELRCKVFPIKHYQDKIRP--------YIQLPSHSNITGIVEVILGETKA 73 Query: 412 LVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLV- 470 V G +H ++ R+ + A L Q+ + + + V DL R + Sbjct: 74 YVFFEKDFGDMHSYVRS-RKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFST 132 Query: 471 -NRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK-FSSR-SDVWSYGV 527 R ++ + + +D + + + +PE +N +S + +DVWS GV Sbjct: 133 EERTQLRLESLEDTHIMKGEDDALSDKHGC---PAYVSPEILNTTGTYSGKAADVWSLGV 189 Query: 528 TMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFL 587 ++ L G+ P+ + + I +G + P P+ L+ + +R Sbjct: 190 MLYTLL-VGRYPFHDSDPSALFSKIRRG-QFCIPEHISPKARCLIRSLLRREPSERLTAP 247 Query: 588 TVEQRMRACYYSLAS 602 + + + S+ Sbjct: 248 EI--LLHPWFESVLE 260 >5CEK-A nrPDB Length = 263 Score = 110 bits (275), Expect = 2e-24, Method: Composition-based stats. Identities = 39/255 (15%), Positives = 90/255 (35%), Gaps = 20/255 (7%) Query: 352 VRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALM 411 V + + +++ + +K +K + + I ++ V E Sbjct: 25 VSRALCIHTGRELRCKVFPIKHYQDKIRP--------YIQLPSHSNITGIVEVILGETKA 76 Query: 412 LVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLV- 470 V G +H ++ R+ + A L Q+ + + + V DL R + Sbjct: 77 YVFFEKDFGDMHSYVRS-RKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFST 135 Query: 471 -NRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK-FSSR-SDVWSYGV 527 R ++ + + +D + + + +PE +N +S + +DVWS GV Sbjct: 136 EERTQLRLESLEDTHIMKGEDDALSDKHGC---PAYVSPEILNTTGTYSGKAADVWSLGV 192 Query: 528 TMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFL 587 ++ L G+ P+ + + I +G + P P+ L+ + +R Sbjct: 193 MLYTLL-VGRYPFHDSDPSALFSKIRRG-QFCIPEHISPKARCLIRSLLRREPSERLTAP 250 Query: 588 TVEQRMRACYYSLAS 602 + + + S+ Sbjct: 251 EI--LLHPWFESVLE 263 >5M07-A nrPDB Length = 276 Score = 109 bits (272), Expect = 5e-24, Method: Composition-based stats. Identities = 38/204 (18%), Positives = 76/204 (37%), Gaps = 28/204 (13%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQG--TEKADTEEMMREAQIMHQLDNPYIVRL 401 LG G V + A+KVL + RE ++ +L +P+I+ + Sbjct: 38 LGASAMGEVYLVQHPGFPGWQ--ALKVLSPAMAADDEFRRRFQRETEVAARLFHPHILEV 95 Query: 402 IGVCQAEA-LMLVMEMAGGGPLHKFLVGKREEI-PVSNVAELLHQVSMGMKYLEEKNFVH 459 + + L + M+ G + + + + PV V ++ V+ + Y ++ +H Sbjct: 96 HDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYAHQRGLLH 155 Query: 460 RDLAARNVLLVN----RHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK 515 RD+ NV+L + ++DFG++ + APE Sbjct: 156 RDVNPANVVLTSQSAGDQRILLADFGIASQ-----------------PSYPAPELSAGAD 198 Query: 516 FSSRSDVWSYGVTMWEALSYGQKP 539 R+D ++ +T + G P Sbjct: 199 VDGRADQYALALTAIHLFA-GAPP 221 >2PZI-A nrPDB Length = 681 Score = 108 bits (270), Expect = 7e-24, Method: Composition-based stats. Identities = 44/220 (20%), Positives = 84/220 (38%), Gaps = 22/220 (10%) Query: 316 ESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT 375 SPYS +L + + + + G G + + R V +K L Sbjct: 63 GSPYSFLPQLNPGDIVAGQYEV---KGCIAHGGLGWIYLALDRNVN-GRPVVLKGLVHSG 118 Query: 376 EKADTEEMMREAQIMHQLDNPYIVRLIGVCQ-----AEAL-MLVMEMAGGGPLHKFLVGK 429 + M E Q + ++ +P IV++ + + + +VME GG L K Sbjct: 119 DAEAQAMAMAERQFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLK---RSK 175 Query: 430 REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD 489 +++PV+ L ++ + YL V+ DL N++L K+ D G + + Sbjct: 176 GQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSF 234 Query: 490 DSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTM 529 Y + APE + + +D+++ G T+ Sbjct: 235 GYLY-------GTPGFQAPEIVRTGP-TVATDIYTVGRTL 266 >4Y12-A nrPDB Length = 375 Score = 107 bits (268), Expect = 1e-23, Method: Composition-based stats. Identities = 44/220 (20%), Positives = 84/220 (38%), Gaps = 22/220 (10%) Query: 316 ESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT 375 SPYS +L + + + + G G + + R V +K L Sbjct: 102 GSPYSFLPQLNPGDIVAGQYEV---KGCIAHGGLGWIYLALDRNVN-GRPVVLKGLVHSG 157 Query: 376 EKADTEEMMREAQIMHQLDNPYIVRLIGVCQ-----AEAL-MLVMEMAGGGPLHKFLVGK 429 + M E Q + ++ +P IV++ + + + +VME GG L K Sbjct: 158 DAEAQAMAMAERQFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLK---RSK 214 Query: 430 REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD 489 +++PV+ L ++ + YL V+ DL N++L K+ D G + + Sbjct: 215 GQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSF 273 Query: 490 DSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTM 529 Y + APE + + +D+++ G T+ Sbjct: 274 GYLY-------GTPGFQAPEIVRTGP-TVATDIYTVGRTL 305 >2EOB-A nrPDB Length = 124 Score = 107 bits (266), Expect = 2e-23, Method: Composition-based stats. Identities = 30/99 (30%), Positives = 46/99 (46%), Gaps = 2/99 (2%) Query: 156 TAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQ 215 HE PWY+ L+R EAE L DG FL+R R+ +YA++ V H I++ Sbjct: 14 NPHESKPWYYDRLSRGEAEDMLMR-IPRDGAFLIRKREGTDSYAITFRARGKVKHCRINR 72 Query: 216 DKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEAC 254 D + + F++L +LV Y + A L+ Sbjct: 73 D-GRHFVLGTSAYFESLVELVSYYEKHALYRKMRLRYPV 110 Score = 66.2 bits (160), Expect = 4e-11, Method: Composition-based stats. Identities = 29/113 (25%), Positives = 44/113 (38%), Gaps = 4/113 (3%) Query: 2 PDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPI 61 P+P P++Y +SR EAE+ L DG FL+R+ + Y ++ + H I Sbjct: 13 PNPHESKPWYYDRLSRGEAEDMLMRIPR-DGAFLIRKREGT-DSYAITFRARGKVKHCRI 70 Query: 62 ERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGV 114 R + + EL +Y + LR P P LE G Sbjct: 71 NRDGR-HFVLGTSAYFESLVELVSYYEKHALYRKMRLRYPVT-PELLERYSGP 121 >6EQI-C nrPDB Length = 433 Score = 103 bits (258), Expect = 2e-22, Method: Composition-based stats. Identities = 55/318 (17%), Positives = 98/318 (30%), Gaps = 74/318 (23%) Query: 335 DNLLIADIELGCGNFGSVRQGVYRMRKKQIDV---AIKVLK----QGTEKADTEEMMRE- 386 D L + + + G V + + A+K++ + A + M RE Sbjct: 15 DELDLGE-PIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRET 73 Query: 387 --------------AQIMHQLD-----NPYIVRLIGVCQAE------------------- 408 + + +P IVR+ V Sbjct: 74 VPAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRI 133 Query: 409 ---------ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 +L LVM+ L ++L K + + LL Q+ + ++ N H Sbjct: 134 NPEGSGRNMSLFLVMKRYDC-TLKEYLRDKTP--NMRSSILLLSQLLEAVAHMNIHNISH 190 Query: 460 RDLAARNVLLVNRH-----YAKISDFGLS---KALGADDSYYTARSAGKWPLKWYAPECI 511 RDL + N+L+ I+DFG K G Y + APE Sbjct: 191 RDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEIA 250 Query: 512 NFRKFS------SRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP 565 N + + +SD+W+ G +E + P+ + ++ E P P Sbjct: 251 NAKPGTFSWLNYKKSDLWAVGAIAYEIFNI-DNPFYDKTMKLLSKSYKEEDLPELPDTIP 309 Query: 566 PELYALMSDCWIYKWEDR 583 + L+S+ R Sbjct: 310 FIIRNLVSNMLSRSTNKR 327 >5UV4-A nrPDB Length = 311 Score = 103 bits (258), Expect = 2e-22, Method: Composition-based stats. Identities = 43/222 (19%), Positives = 89/222 (40%), Gaps = 18/222 (8%) Query: 325 LKDKKLFLKRDNLLIADIEL-GCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEM 383 L D + + L A E+ G G+ + + +K LK+G K+ +E Sbjct: 13 LFDNSVVFTAEELSCAPAEIIGRSCHGTSYKATL---DNGYMLTVKWLKEGFAKSK-KEF 68 Query: 384 MREAQIMHQLDNPYIVRLIGVC---QAEALMLVMEMAGGGPLHKFLVGKREEI----PVS 436 RE + + + +P +V L G + +++ + A L +L E Sbjct: 69 SREIKKLGSVRHPNLVPLRGYYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAG 128 Query: 437 NVAELLHQVSMGMKYLEEKNFV-HRDLAARNVLL-VNRHYAKISDFGLSKALGADDSYYT 494 + ++ + YL + + H ++ + NVL+ + A ++D+ L + + Sbjct: 129 QRLNIAIDIARCLDYLHNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIG--MA 186 Query: 495 ARSAGKWPLKWYAPE--CINFRKFSSRSDVWSYGVTMWEALS 534 + L + PE + S +SDV+++GV + E L+ Sbjct: 187 EQVLNAGALGYSPPEFSSTSKPCPSLKSDVYAFGVILLELLT 228 >2PLE-A nrPDB Length = 105 Score = 102 bits (254), Expect = 5e-22, Method: Composition-based stats. Identities = 32/104 (30%), Positives = 49/104 (47%), Gaps = 3/104 (2%) Query: 157 AHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQD 216 HE WYH+SLTR +AE L DG FL+R R E +YA+S + H + Q Sbjct: 5 IHESKEWYHASLTRAQAEHMLMR-VPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQ- 62 Query: 217 KAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSAS 260 G+ + ++FD+L L+ Y + L+ ++S Sbjct: 63 -EGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEENSS 105 Score = 61.9 bits (149), Expect = 8e-10, Method: Composition-based stats. Identities = 22/95 (23%), Positives = 43/95 (45%), Gaps = 4/95 (4%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69 +++ S++RA+AE H+ + DG FL+R+ Y +S + + H ++++ Sbjct: 11 WYHASLTRAQAE-HMLMRVPRDGAFLVRKR-NEPNSYAISFRAEGKIKHCRVQQEGQTV- 67 Query: 70 AIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNR 104 + G +L +Y + P LR P N Sbjct: 68 -MLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINE 101 >1GRI-A nrPDB Length = 217 Score = 99.3 bits (246), Expect = 5e-21, Method: Composition-based stats. Identities = 29/81 (35%), Positives = 48/81 (59%), Gaps = 3/81 (3%) Query: 161 MPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSLIYGKTVYHYLISQDKAG 219 PW+ + R +AE L S + DG FL+R + G ++LS+ +G V H+ + +D AG Sbjct: 58 HPWFFGKIPRAKAEEML-SKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAG 116 Query: 220 KYCIPEGTKFDTLWQLVEYLK 240 KY + KF++L +LV+Y + Sbjct: 117 KYFL-WVVKFNSLNELVDYHR 136 Score = 80.0 bits (196), Expect = 3e-15, Method: Composition-based stats. Identities = 26/83 (31%), Positives = 39/83 (46%), Gaps = 2/83 (2%) Query: 9 PFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGT 68 P+F+G I RA+AEE L DG FL+R+ + G + LS+ HF + R G Sbjct: 59 PWFFGKIPRAKAEEMLSKQ-RHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGK 117 Query: 69 YAIAGGKAHCGPAELCEFYSRDP 91 Y + K EL +++ Sbjct: 118 YFLWVVK-FNSLNELVDYHRSTS 139 >4M4Z-A nrPDB Length = 170 Score = 95.5 bits (236), Expect = 7e-20, Method: Composition-based stats. Identities = 33/109 (30%), Positives = 47/109 (43%), Gaps = 10/109 (9%) Query: 4 PAAHLP-----FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDV---- 54 P+ H+ + Y +SR +AEE L L G G FL+R+ G Y LS+ Sbjct: 60 PSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASW 119 Query: 55 -RFHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPC 102 R H+ I NG I+ L + YS D + C L++PC Sbjct: 120 DRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPC 168 Score = 90.4 bits (223), Expect = 2e-18, Method: Composition-based stats. Identities = 30/101 (29%), Positives = 44/101 (43%), Gaps = 6/101 (5%) Query: 160 RMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYG-----KTVYHYLI 213 W + L+RE+AE L G FL+R + + G+Y+LS+ + HY I Sbjct: 68 SHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRI 127 Query: 214 SQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEAC 254 G I F +L LV++ AD + LKE C Sbjct: 128 HCLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPC 168 >4JRN-A nrPDB Length = 372 Score = 89.3 bits (220), Expect = 5e-18, Method: Composition-based stats. Identities = 40/287 (13%), Positives = 87/287 (30%), Gaps = 60/287 (20%) Query: 338 LIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD--- 394 L+ LG G F +V + +++ V + + ++ ++ RE+ Sbjct: 70 LVRGAPLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAK 129 Query: 395 --------NPY------------------IVRLIGVCQAEALMLVMEMAGGGPLHKFLV- 427 + ++ L +L+M + K + Sbjct: 130 TAKDAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMR--AEADMSKVISW 187 Query: 428 ------GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFG 481 + E + L Q + ++ + VH D+ N LL+ + DFG Sbjct: 188 VFGDASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFG 247 Query: 482 LSKALGADDSYYTARSAGK--WPLKWYAPEC---INFRKFSSRSDVWSYGVTMWEALSYG 536 +Y S G+ + PE ++ +D W G+T++ + Sbjct: 248 ---------TYRINNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLY-CIWCK 297 Query: 537 QKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDR 583 ++P + + F + P P + L+ + R Sbjct: 298 ERPTPADGIWDYLHFADC-------PSTPELVQDLIRSLLNRDPQKR 337 >6CMQ-A nrPDB Length = 427 Score = 87.0 bits (214), Expect = 2e-17, Method: Composition-based stats. Identities = 41/147 (27%), Positives = 64/147 (43%), Gaps = 18/147 (12%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHD----------VRFHHF 59 +F+G +S EAE+ L G G FL+R+ G +VLS+ + H Sbjct: 10 WFHGHLSGKEAEKLLTEKG-KHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHV 68 Query: 60 PIERQLNGTYAIAGGKAHCGPAELCEFYSRDPD----GLPCNLRKPCN--RPSGLEPQPG 113 I Q Y + GG+ +L E Y ++P G L++P N R + E + Sbjct: 69 MIRCQ-ELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESR 127 Query: 114 VFDCLRDAMVRDYVRQTWKLEGEALEQ 140 V + + A D V+Q + E E L+Q Sbjct: 128 VRELSKLAETTDKVKQGFWEEFETLQQ 154 Score = 86.6 bits (213), Expect = 3e-17, Method: Composition-based stats. Identities = 36/124 (29%), Positives = 57/124 (45%), Gaps = 20/124 (16%) Query: 155 TTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSLIYG-------- 205 ER W+H L+ +EAE+ L + G FL+R + G + LS+ G Sbjct: 4 DPTSER--WFHGHLSGKEAEKLLTEKGK-HGSFLVRESQSHPGDFVLSVRTGDDKGESND 60 Query: 206 --KTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLK----ADGLIYCLKEACPNSSA 259 V H +I + + KY + G +FD+L LVE+ K G + LK+ N++ Sbjct: 61 GKSKVTHVMI-RCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPL-NTTR 118 Query: 260 SNAS 263 NA+ Sbjct: 119 INAA 122 >2EYZ-A nrPDB Length = 304 Score = 84.3 bits (207), Expect = 1e-16, Method: Composition-based stats. Identities = 32/124 (25%), Positives = 47/124 (37%), Gaps = 22/124 (17%) Query: 156 TAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRK-EQGTYALSLIYGKTVYHYLIS 214 + ER WY L+R+EA L Q G FL+R G Y LS+ V HY+I+ Sbjct: 6 DSEERSSWYWGRLSRQEAVALL--QGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIIN 63 Query: 215 QDKA-----------------GKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNS 257 + I + +FD+L L+E+ K+ L E S Sbjct: 64 SSGPRPPVPPSPAQPPPGVSPSRLRIGD-QEFDSLPALLEFYKIHYLDT-TTLIEPVSRS 121 Query: 258 SASN 261 + Sbjct: 122 RQGS 125 Score = 72.7 bits (177), Expect = 4e-13, Method: Composition-based stats. Identities = 28/105 (26%), Positives = 38/105 (36%), Gaps = 20/105 (19%) Query: 3 DPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIE 62 D +++G +SR EA L G G+FL+R S G YVLS+ + R H+ I Sbjct: 6 DSEERSSWYWGRLSRQEA--VALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIIN 63 Query: 63 RQLN-----------------GTYAIAGGKAHCGPAELCEFYSRD 90 I + PA L EFY Sbjct: 64 SSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPA-LLEFYKIH 107 >6EAS-A nrPDB Length = 308 Score = 84.3 bits (207), Expect = 1e-16, Method: Composition-based stats. Identities = 47/247 (19%), Positives = 91/247 (36%), Gaps = 44/247 (17%) Query: 373 QGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALM---LVMEMAGGGPLHKFLVGK 429 + K + + ++ + ++ + + L+G C+ E +V E A G L + L + Sbjct: 78 KDWSKENESQYRKKITNLSKVSHKNFMNLLGYCEEEHPFTRVMVFEYAPNGTLFEHLHVR 137 Query: 430 R-EEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARN-----VLLVNRHYAKISDFGLS 483 E++ + ++ ++++ + A RN V L + AK+SD Sbjct: 138 EAEKLDWMARLRISMGIAYCLEHMHQLQTP---AALRNFDSTTVYLTDDFAAKVSDL--- 191 Query: 484 KALGADDSYYTARSAGKWPLKWYAP--ECINFRKFSSRSDVWSYGVTMWEALSYGQKPYK 541 D + + + + +P E I + YG+ + E L+ G+ P Sbjct: 192 -EFWNDAKGHNSTTNNELAF---SPDMEDIVRK----------YGMVLLEILT-GRVPSS 236 Query: 542 KMKGPE---VMAFIEQGKRME---------CPPECPPELYALMSDCWIYKWEDRPDFLTV 589 + GP V + E G R+E P + L ++ C + RP V Sbjct: 237 EDDGPLENWVSRYFEGGMRLEELIDPSIGFFPEDTARALCEVVRSCIDRDPKKRPQMKEV 296 Query: 590 EQRMRAC 596 RMR Sbjct: 297 AARMREI 303 >5CLR-A nrPDB Length = 451 Score = 81.2 bits (199), Expect = 1e-15, Method: Composition-based stats. Identities = 49/261 (18%), Positives = 92/261 (35%), Gaps = 41/261 (15%) Query: 361 KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC---QAEALMLVMEMA 417 +K +K E E E + +L RL+G Q + ++ Sbjct: 102 DDGKTYFLKSVKIDAES--LTEFTNEKDTLSKLG-----RLVGTFFNEQTQVHYILTTFI 154 Query: 418 GGGPLHKFLVGKREEIPVSN---VAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHY 474 G L ++ + + + V ++ V +K E +HRDL N++L Sbjct: 155 KGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGNIMLDADMQ 214 Query: 475 AKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK---FSSRSDVWSYGVTMWE 531 + DFG S + A + APE FS SD+++ ++ E Sbjct: 215 CHLVDFGSSSSDKEPKP------ASWGTASYLAPELNAQEDFIAFSQVSDLFALAYSLDE 268 Query: 532 ALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQ 591 + P++++K +V I+ + E + LMS+ E Sbjct: 269 LFN----PFRQVKFAKVDIGIKNKHLVLLHAEIEACITGLMSN---------------ET 309 Query: 592 RMRACYYSLASKVEGPPGSTQ 612 +R Y+S +++ P S + Sbjct: 310 SVRTLYFSRILQLQRVPESFK 330 >5UU1-A nrPDB Length = 324 Score = 78.9 bits (193), Expect = 7e-15, Method: Composition-based stats. Identities = 52/230 (22%), Positives = 88/230 (38%), Gaps = 27/230 (11%) Query: 336 NLLIADIELGCGNFGSVRQG--VYRMRKKQIDVAIKV-------------LKQGTEKADT 380 N + ++G G FG + + K V +KV Q K D Sbjct: 16 NQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHV-VKVEYQENGPLFSELKFYQRVAKKDC 74 Query: 381 EEMMREAQIMHQLDNP--YIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNV 438 + E + + L P Y L +VME G L K + G+ S V Sbjct: 75 IKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERL-GIDLQK-ISGQNGTFKKSTV 132 Query: 439 AELLHQVSMGMKYLEEKNFVHRDLAARNVLL--VNRHYAKISDFGLSKALGADDSYYT-- 494 +L ++ ++Y+ E +VH D+ A N+LL N ++D+GLS + ++ Sbjct: 133 LQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQ 192 Query: 495 --ARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKK 542 R +++ + + S RSDV G M L G+ P+++ Sbjct: 193 ENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLC-GKLPWEQ 241 >5GZ9-A nrPDB Length = 305 Score = 77.7 bits (190), Expect = 1e-14, Method: Composition-based stats. Identities = 51/314 (16%), Positives = 97/314 (30%), Gaps = 64/314 (20%) Query: 323 EELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEE 382 EEL+ + LKR +G G V ++ + VA L + T E+ Sbjct: 30 EELRTEVRQLKR---------VGEGAVKRVFLSEWK----EHKVA---LSRLTRLEMKED 73 Query: 383 MMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKF-----LVGKREEIPVSN 437 + Q++ L + ++V L+G C+ + ++ E G L L ++ + Sbjct: 74 FLHGLQMLKSLQSEHVVTLVGYCEEDG-TILTEYHPLGSLSNLEETLQLSKYQDVNTWQH 132 Query: 438 VAELLHQVSMGMKYLEEKNFVHRDLAARN--------VLLVNRHYAKISDFGLSKALGAD 489 +L + + YL R + N LL + +D + D Sbjct: 133 RLQLAMEYVSIINYLHHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHD 192 Query: 490 DSYYTARSAGKWPLKWYAPECI------------NFRKFSSRSDVWSYGVTMWEALSYGQ 537 + + APE + ++ + D+W Sbjct: 193 SGVLIKCGHRELHGDFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW-------------- 238 Query: 538 KPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACY 597 K P+V +F+ +E L+ + C +RP V + + Sbjct: 239 ------KIPDVSSFLL--GHVEGSDMVRFHLFDIHKACKSQIPAERPTAQNVLDAYQRVF 290 Query: 598 YSLASKVEGPPGST 611 +SL V Sbjct: 291 HSLRDTVMSQTKEM 304 >5M6U-B nrPDB Length = 724 Score = 77.7 bits (190), Expect = 2e-14, Method: Composition-based stats. Identities = 27/104 (25%), Positives = 42/104 (40%), Gaps = 7/104 (6%) Query: 156 TAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQ 215 H+ W S R +AE L + DG FL+R +QG YA S++ V H +I++ Sbjct: 617 PHHDEKTWNVGSSNRNKAENLL--RGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINK 674 Query: 216 DKAGKYCIPEGTKFDTLWQLVEYLKL-----KADGLIYCLKEAC 254 G + +L +LV + + D L L Sbjct: 675 TATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPV 718 Score = 63.1 bits (152), Expect = 3e-10, Method: Composition-based stats. Identities = 24/90 (26%), Positives = 41/90 (45%), Gaps = 5/90 (5%) Query: 157 AHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ--GTYALSLIYGKTVYHYLIS 214 + + WY ++REE KL A DG FL+R + G Y L+L G I Sbjct: 327 SLQDAEWYWGDISREEVNEKLRDTA--DGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIF 384 Query: 215 QDKAGKYCIPEGTKFDTLWQLVEYLKLKAD 244 + GKY + F ++ +L+ + + ++ Sbjct: 385 H-RDGKYGFSDPLTFSSVVELINHYRNESL 413 Score = 62.3 bits (150), Expect = 6e-10, Method: Composition-based stats. Identities = 27/97 (27%), Positives = 38/97 (39%), Gaps = 8/97 (8%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69 + GS +R +AE L+ G DG FL+R+ + G Y S+V D H I + G Sbjct: 624 WNVGSSNRNKAENLLR--GKRDGTFLVRESSKQ-GCYACSVVVDGEVKHCVINKTATGYG 680 Query: 70 AIAGGKAHCGPAELCEFYS-----RDPDGLPCNLRKP 101 + EL Y + D L L P Sbjct: 681 FAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYP 717 Score = 57.3 bits (137), Expect = 2e-08, Method: Composition-based stats. Identities = 27/103 (26%), Positives = 39/103 (37%), Gaps = 9/103 (8%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSL-GGYVLSLVHDVRFHHFPIERQLNGT 68 +++G ISR E E KL ADG FL+R + G Y L+L I + +G Sbjct: 333 WYWGDISREEVNE--KLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHR-DGK 389 Query: 69 YAIAGGKAHCGPAELCEFYSRDP-----DGLPCNLRKPCNRPS 106 Y + EL Y + L L P ++ Sbjct: 390 YGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQ 432 >2RSV-A nrPDB Length = 403 Score = 77.0 bits (188), Expect = 3e-14, Method: Composition-based stats. Identities = 46/264 (17%), Positives = 92/264 (34%), Gaps = 43/264 (16%) Query: 341 DIELGCGNFGSVRQGVYRMR---KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNP- 396 + +G G FG + +KV E +D + E + + P Sbjct: 47 GLPIGQGGFGCIYLADMNSSESVGSDAPCVVKV-----EPSDNGPLFTELKFYQRAAKPE 101 Query: 397 ----YI----VRLIGV--CQAEAL---------MLVMEMAGGGPLHKFLVGKREEIPVSN 437 +I ++ +GV L ++M+ G L K + Sbjct: 102 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDR-FGSDLQKIYEANAKRFSRKT 160 Query: 438 VAELLHQVSMGMKYLEEKNFVHRDLAARNVLLV--NRHYAKISDFGLSKALGADDSYY-- 493 V +L ++ ++Y+ E +VH D+ A N+LL N + D+GL+ + + Sbjct: 161 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 220 Query: 494 --TARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAF 551 + +++ + + N S R D+ G M + L+ G P++ + + Sbjct: 221 KEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWED--NLKDPKY 277 Query: 552 IEQGKRMECPPECPPELYALMSDC 575 + K + +LM C Sbjct: 278 VRDSKI-----RYRENIASLMDKC 296 >2LAV-A nrPDB Length = 361 Score = 76.6 bits (187), Expect = 3e-14, Method: Composition-based stats. Identities = 46/264 (17%), Positives = 92/264 (34%), Gaps = 43/264 (16%) Query: 341 DIELGCGNFGSVRQGVYRMR---KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNP- 396 + +G G FG + +KV E +D + E + + P Sbjct: 40 GLPIGQGGFGCIYLADMNSSESVGSDAPCVVKV-----EPSDNGPLFTELKFYQRAAKPE 94 Query: 397 ----YI----VRLIGV--CQAEAL---------MLVMEMAGGGPLHKFLVGKREEIPVSN 437 +I ++ +GV L ++M+ G L K + Sbjct: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDR-FGSDLQKIYEANAKRFSRKT 153 Query: 438 VAELLHQVSMGMKYLEEKNFVHRDLAARNVLLV--NRHYAKISDFGLSKALGADDSYY-- 493 V +L ++ ++Y+ E +VH D+ A N+LL N + D+GL+ + + Sbjct: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEY 213 Query: 494 --TARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAF 551 + +++ + + N S R D+ G M + L+ G P++ + + Sbjct: 214 KEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLPWED--NLKDPKY 270 Query: 552 IEQGKRMECPPECPPELYALMSDC 575 + K + +LM C Sbjct: 271 VRDSKI-----RYRENIASLMDKC 289 >4IX6-A nrPDB Length = 350 Score = 76.2 bits (186), Expect = 4e-14, Method: Composition-based stats. Identities = 49/271 (18%), Positives = 88/271 (32%), Gaps = 67/271 (24%) Query: 321 DPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADT 380 P+ L+ +D + + LG GNFG+V +GV++ DV +K K A+ Sbjct: 6 GPKTLRRTPGVEPKD-IRVLPGPLGSGNFGTVFRGVFKG---DQDVVLKNAKADVMAAE- 60 Query: 381 EEMMREAQIMHQLDNPY----IVRLIGVCQ--------------AEALMLVMEMAGGGPL 422 E + E + + + + R +G + E L L+ A G Sbjct: 61 ELLECEMDVNYHV-HANAKGTCARFMGCIELGAKDGGEIYNGTLTEGLWLM--WANEGEN 117 Query: 423 HKFLVGKREEIPVSNVAEL------------LHQVSMGMKYLEEKNFVHRDLAARNVLLV 470 + +R P++ + ++ + L E VHRD+ N++ Sbjct: 118 TVEALMRRGTAPLATAMACADATELGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAA 177 Query: 471 NR--HYAKISDFGLSK-ALGADDSYYTARSAGKWPLKW--------YAP----------- 508 + K+ D G + L ++ G ++ P Sbjct: 178 EKDGGVLKLIDLGAAALCLPLPETLNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAA 237 Query: 509 ---ECINFRKFSSRSDVWSYGVTMWEALSYG 536 E +F S WS G M + G Sbjct: 238 KLWEAHKPDRFDS----WSAGCVMLQLAVVG 264 >5GZA-A nrPDB Length = 290 Score = 72.3 bits (176), Expect = 6e-13, Method: Composition-based stats. Identities = 45/292 (15%), Positives = 87/292 (29%), Gaps = 70/292 (23%) Query: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIG 403 +G G V + + VA+ VL + ++ + ++ L + ++V L+G Sbjct: 33 IGQGAVKKVYLSEW----QGQKVALSVL---SSDQYADDFLHGLSMLRALQSSHVVTLVG 85 Query: 404 VCQAEALMLVMEMAGGGP---LHKFLVGKREEI--PVSNVAELLHQVSMGMKYLEE--KN 456 VC+ +A+ V E G L L +R +L + YL Sbjct: 86 VCEEDAV-FVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLAYLHSSPAG 144 Query: 457 F--------VHRDLAARNVLLVNRHYAKISDFGLSKALG-----ADDSYYTARSAGKWPL 503 +H+ L LL + L+ L + Sbjct: 145 IRVMCDSNDLHKTL--SQFLLASDMRL------LANDLDALPEVEKGGLGVKCGHHELTG 196 Query: 504 KWYAPECI------------NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAF 551 + APE + + ++D+W + P ++ Sbjct: 197 DFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW-------------KIP---DVTRFLLGD 240 Query: 552 IEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASK 603 + G + L+ + S+C + RP V R+ Y S+ Sbjct: 241 VLGGDVIHF------HLFQIYSECKRKEAHMRPTAREVLSVYRSVYDSMMES 286 >2JII-A nrPDB Length = 352 Score = 69.3 bits (168), Expect = 5e-12, Method: Composition-based stats. Identities = 39/224 (17%), Positives = 83/224 (37%), Gaps = 17/224 (7%) Query: 402 IGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 GV Q + LV+ G V + + +V ++ ++ +++L E +VH + Sbjct: 125 FGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGN 184 Query: 462 LAARNVLLV--NRHYAKISDFGLSKALGADDSYY----TARSAGKWPLKWYAPECINFRK 515 + A N+ + ++ ++ +G + + +RS + L++ + + Sbjct: 185 VTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCG 244 Query: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKM--KGPEVMAFIEQ--GKRMECPPEC------P 565 S RSD+ S G M + L YG P+ ++M ++ K C Sbjct: 245 PSRRSDLQSLGYCMLKWL-YGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPS 303 Query: 566 PELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPG 609 L + +E++P + + + A L P G Sbjct: 304 ETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDLRVSPYDPIG 347 >2KK6-A nrPDB Length = 116 Score = 68.9 bits (167), Expect = 6e-12, Method: Composition-based stats. Identities = 23/80 (28%), Positives = 35/80 (43%), Gaps = 7/80 (8%) Query: 161 MPWYHSSLTREEAERKLYSGAQTDGKFLLRPRK-EQGTYALSLIYGKTVYHYLISQDKAG 219 WYH ++ R EA+ L G FL+R + G Y LS+ H++I Sbjct: 17 QDWYHGAIPRIEAQELLKKQ----GDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNM 72 Query: 220 KYCIPEGTKFDTLWQLVEYL 239 EGT F + QL+++ Sbjct: 73 YRF--EGTGFSNIPQLIDHH 90 Score = 64.6 bits (156), Expect = 1e-10, Method: Composition-based stats. Identities = 26/91 (28%), Positives = 40/91 (43%), Gaps = 6/91 (6%) Query: 4 PAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIER 63 P A +++G+I R EA+E LK G FL+R+ G YVLS+ D + HF I+ Sbjct: 13 PLAEQDWYHGAIPRIEAQELLKKQ----GDFLVRESHGKPGEYVLSVYSDGQRRHFIIQY 68 Query: 64 QLNGTYAIAGGKAHCGPAELCEFYSRDPDGL 94 N G +L + + + Sbjct: 69 VDNMYRF--EGTGFSNIPQLIDHHYTTKQVI 97 >1KA6-A nrPDB Length = 128 Score = 68.1 bits (165), Expect = 1e-11, Method: Composition-based stats. Identities = 25/102 (24%), Positives = 44/102 (43%), Gaps = 7/102 (6%) Query: 164 YHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSLIYGKTVYHYLISQDKAGKYC 222 YH ++RE E+ L + DG +LLR + G Y L ++Y +Y Y +SQ + G + Sbjct: 7 YHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWS 65 Query: 223 IPE-----GTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSA 259 F + L+ + G++ L+ S+ Sbjct: 66 AETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEKKSS 107 Score = 66.2 bits (160), Expect = 4e-11, Method: Composition-based stats. Identities = 22/108 (20%), Positives = 43/108 (39%), Gaps = 6/108 (5%) Query: 11 FYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYA 70 ++G ISR E+ L G+ DG +LLR G Y L +++ + + + + G+++ Sbjct: 7 YHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWS 65 Query: 71 IAG-----GKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPG 113 + L + + G+ L+ P + S G Sbjct: 66 AETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEKKSSARSTQG 113 >4O1O-A nrPDB Length = 717 Score = 67.3 bits (163), Expect = 2e-11, Method: Composition-based stats. Identities = 30/205 (14%), Positives = 70/205 (34%), Gaps = 37/205 (18%) Query: 355 GVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD-NPYIVRLIGV-CQAEALML 412 G+Y + +VA+K +G+ + +E + N +V G L + Sbjct: 361 GIYLGLYEDQEVAVKRFSEGSTRG-----QQEVSCLQSSRANDNVVTFYGSESDGSCLHV 415 Query: 413 VMEMAGGGPLHKFLVGKREE----IPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVL 468 + + L + L R + + +L + + L + H+DL +N+L Sbjct: 416 CLALCEY-TLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNIL 474 Query: 469 LVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVT 528 + +++ ++DF +KW + D+ + G+ Sbjct: 475 IDSKNGTFLADF-------------------DKSIKW------AEDPQKIKRDLEALGLL 509 Query: 529 MWEALSYGQKPYKKMKGPEVMAFIE 553 + + G ++ +K I+ Sbjct: 510 VLYVVKKGDISFETLKNQSFEEVIQ 534 >2CS0-A nrPDB Length = 119 Score = 67.3 bits (163), Expect = 2e-11, Method: Composition-based stats. Identities = 28/105 (26%), Positives = 47/105 (44%), Gaps = 4/105 (3%) Query: 162 PWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKY 221 W+H +++RE+AE L +Q G FL+R Y LS + H+++ G + Sbjct: 17 EWFHGAISREDAENLL--ESQPLGSFLIRVSHSHVGYTLSYKAQSSCCHFMVKLLDDGTF 74 Query: 222 CIP-EGTKFDTLWQLVEYLKLKA-DGLIYCLKEACPNSSASNASG 264 IP E +L LV + + K + L + C + +SG Sbjct: 75 MIPGEKVAHTSLDALVTFHQQKPIEPRRELLTQPCRQKDSGPSSG 119 Score = 63.1 bits (152), Expect = 4e-10, Method: Composition-based stats. Identities = 34/106 (32%), Positives = 49/106 (46%), Gaps = 6/106 (5%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69 +F+G+ISR +AE L+ G FL+R +G Y LS HF ++ +GT+ Sbjct: 18 WFHGAISREDAENLLESQ--PLGSFLIRVSHSHVG-YTLSYKAQSSCCHFMVKLLDDGTF 74 Query: 70 AIAGGK-AHCGPAELCEFYSRDP-DGLPCNLRKPCNRPSGLEPQPG 113 I G K AH L F+ + P + L +PC R P G Sbjct: 75 MIPGEKVAHTSLDALVTFHQQKPIEPRRELLTQPC-RQKDSGPSSG 119 >1M27-A nrPDB Length = 104 Score = 66.2 bits (160), Expect = 4e-11, Method: Composition-based stats. Identities = 24/99 (24%), Positives = 42/99 (42%), Gaps = 7/99 (7%) Query: 164 YHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSLIYGKTVYHYLISQDKAGKYC 222 YH ++RE E+ L + DG +LLR + G Y L ++Y +Y Y +SQ + G + Sbjct: 7 YHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWS 65 Query: 223 IPE-----GTKFDTLWQLVEYLKLKADGLIYCLKEACPN 256 F + L+ + G++ L+ Sbjct: 66 AETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEK 104 Score = 63.9 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 20/99 (20%), Positives = 41/99 (41%), Gaps = 6/99 (6%) Query: 11 FYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYA 70 ++G ISR E+ L G+ DG +LLR G Y L +++ + + + + G+++ Sbjct: 7 YHGKISRETGEKLLLATGL-DGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWS 65 Query: 71 IAG-----GKAHCGPAELCEFYSRDPDGLPCNLRKPCNR 104 + L + + G+ L+ P + Sbjct: 66 AETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEK 104 >5DMZ-A nrPDB Length = 365 Score = 65.8 bits (159), Expect = 5e-11, Method: Composition-based stats. Identities = 57/355 (16%), Positives = 118/355 (33%), Gaps = 41/355 (11%) Query: 268 PTLPAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKD 327 P P+ T+ P + D + ++ KP +T ++ +K Sbjct: 2 PMDPSSLGTVDAPNFIVGNPWDDKLIFK--LLSGLSKPVSSYPNTFEWQCKLP---AIKP 56 Query: 328 KKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREA 387 K F L+ LG G F V + + K + + + A+ E Sbjct: 57 KTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKN-KQKFVLKVQKPANPWEFYIGT 115 Query: 388 QIMHQL----DNPYIVRLIGV-CQAEALMLVMEMAGGGPLHK----FLVGKREEIPVSNV 438 Q+M +L + + ++ +LV E+ G L + + +P V Sbjct: 116 QLMERLKPSMQHMF-MKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLV 174 Query: 439 AELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHY-----------AKISDFGLSKALG 487 ++ ++ + + +H D+ N +L N + D G S + Sbjct: 175 ISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMK 234 Query: 488 ADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPE 547 T +A + E ++ + ++ + D + T++ L +G Y K+K E Sbjct: 235 LFPKG-TIFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCML-FGT--YMKVKN-E 289 Query: 548 VMAFIEQGKRMECPP-ECPPELYALMS---DCWIYKWEDRPDFLTVEQRMRACYY 598 +G P + E + +M DC P + Q+++ + Sbjct: 290 GGECKPEGLFRRLPHLDMWNEFFHVMLNIPDCHHL-----PSLDLLRQKLKKVFQ 339 >1MIL-A nrPDB Length = 104 Score = 65.4 bits (158), Expect = 7e-11, Method: Composition-based stats. Identities = 27/108 (25%), Positives = 44/108 (40%), Gaps = 12/108 (11%) Query: 155 TTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSLIYGKTVYHYLI 213 + PW+H L+R EAE L Q +G FL+R G Y L+ + H L+ Sbjct: 1 GSQLRGEPWFHGKLSRREAEALL----QLNGDFLVRESTTTPGQYVLTGLQSGQPKH-LL 55 Query: 214 SQDKAGKYCIPEGTKFDTLWQLVEYLKLK-----ADGLIYCLKEACPN 256 D G + +F+++ L+ Y + G CL++ Sbjct: 56 LVDPEG-VVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVER 102 Score = 58.9 bits (141), Expect = 7e-09, Method: Composition-based stats. Identities = 21/82 (25%), Positives = 37/82 (45%), Gaps = 6/82 (7%) Query: 9 PFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGT 68 P+F+G +SR EAE L+L +G FL+R+ + G YVL+ + + H + G Sbjct: 8 PWFHGKLSRREAEALLQL----NGDFLVRESTTTPGQYVLTGLQSGQPKHLLL-VDPEGV 62 Query: 69 YAIAGGKAHCGPAELCEFYSRD 90 + L ++ + Sbjct: 63 VRTKD-HRFESVSHLISYHMDN 83 >4OAU-C nrPDB Length = 699 Score = 65.0 bits (157), Expect = 8e-11, Method: Composition-based stats. Identities = 35/208 (16%), Positives = 71/208 (34%), Gaps = 21/208 (10%) Query: 279 HPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLL 338 + + L S G + KP+ ++ + + K F + Sbjct: 292 YDHSLVKVLLSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIY-RPMIGKLKFFIDEKYK 350 Query: 339 IADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLD-NPY 397 IAD G G+Y ++ +VA+K +G+ RE + N + Sbjct: 351 IADTSEG---------GIYLGFYEKQEVAVKTFCEGS-----PRAQREVSCLQSSRENSH 396 Query: 398 IVRLIGV-CQAEALMLVMEMAGGGP--LHKFLVGKREEIPVSN-VAELLHQVSMGMKYLE 453 +V G L + + + G+ E +L + ++ L Sbjct: 397 LVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH 456 Query: 454 -EKNFVHRDLAARNVLLVNRHYAKISDF 480 + H+DL +N+L+ ++ A ++DF Sbjct: 457 LSCGYTHQDLQPQNILIDSKKAAHLADF 484 >6G4J-A nrPDB Length = 315 Score = 64.6 bits (156), Expect = 1e-10, Method: Composition-based stats. Identities = 28/158 (17%), Positives = 51/158 (32%), Gaps = 26/158 (16%) Query: 336 NLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN 395 N +LG G G V VA+KV D+ + E ++ Sbjct: 26 NTYTLRKQLGKGANGIVYLA----ETSDGHVALKV------SDDSLSITSEVNVLKSFSK 75 Query: 396 PYIVRL-IGVCQAEALML----------VMEMAGGGPLHKFLVGKREEIPVSNVAELLHQ 444 V + + + ME G L K++ K E + L+ Q Sbjct: 76 AQSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGAEW----IPVLMIQ 131 Query: 445 VSMGMKYLEEKNFVHRDLAARNVLLVN-RHYAKISDFG 481 + + L ++ ++ DL N+++ + D G Sbjct: 132 LLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVG 169 >6EWX-A nrPDB Length = 484 Score = 64.3 bits (155), Expect = 2e-10, Method: Composition-based stats. Identities = 41/257 (15%), Positives = 81/257 (31%), Gaps = 66/257 (25%) Query: 406 QAEALMLVMEMAGGGPLHKFLVGK------REEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 + + ++++ F+ E+ V LL Q+ G+++L+E +H Sbjct: 174 EQDCVVVITREVPHQTASDFVRDSVASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIH 233 Query: 460 RDLAARNVLLVNRH-----------------------------------------YAKIS 478 RDL N+LLV+ + IS Sbjct: 234 RDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCPSAAPAATTACQGGPGEKHLPRLIIS 293 Query: 479 DFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQK 538 +F +K T K APE ++ ++ + D + G+ ++E L Sbjct: 294 NFLKAKQKPGG----TTNLQQKKSQARLAPEIVSASQY-RKFDEFQTGILIYELL----- 343 Query: 539 PYKKMKGPEVMAFIEQG--KRMECPP-----ECPPELYALMSDCWIYKWEDRPDFLTVEQ 591 + EV A + + +R + PP P L L R ++ Sbjct: 344 --HQPNPFEVRAQLRERDYRREDLPPLPTLSLYSPGLQQLAHLLLEADPIKRIRIGEAKR 401 Query: 592 RMRACYYSLASKVEGPP 608 ++ + ++ P Sbjct: 402 VLQCLLWGPRRELVEQP 418 >2HDV-A nrPDB Length = 111 Score = 60.8 bits (146), Expect = 2e-09, Method: Composition-based stats. Identities = 20/91 (21%), Positives = 44/91 (48%), Gaps = 3/91 (3%) Query: 154 ATTAHERMPWYHSSLTREEAERKLYSGAQ-TDGKFLLRPRKE-QGTYALSLIYGKTVYHY 211 + PW+H L+R +A + + G + G FL+R + +G L+ + H Sbjct: 2 SDQPLSGYPWFHGMLSRLKAAQLVLEGGTGSHGVFLVRQSETRRGECVLTFNFQGKAKHL 61 Query: 212 LISQDKAGKYCIPEGTKFDTLWQLVEYLKLK 242 +S + AG+ C + F +++ ++E+ ++ Sbjct: 62 RLSLNAAGQ-CRVQHLHFQSIFDMLEHFRVH 91 Score = 56.9 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 19/84 (22%), Positives = 35/84 (41%), Gaps = 2/84 (2%) Query: 9 PFFYGSISRAEAEEHLKLAGM-ADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNG 67 P+F+G +SR +A + + G + G+FL+RQ G VL+ + H + G Sbjct: 10 PWFHGMLSRLKAAQLVLEGGTGSHGVFLVRQSETRRGECVLTFNFQGKAKHLRLSLNAAG 69 Query: 68 TYAIAGGKAHCGPAELCEFYSRDP 91 + ++ E + P Sbjct: 70 QCRVQHLH-FQSIFDMLEHFRVHP 92 >3QWY-A nrPDB Length = 308 Score = 60.0 bits (144), Expect = 3e-09, Method: Composition-based stats. Identities = 26/105 (24%), Positives = 42/105 (40%), Gaps = 14/105 (13%) Query: 150 EKLIATTAHERMPW---YHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLI--- 203 + + T + W Y ++REEA + L + G FL+R G Y+L++ Sbjct: 27 GQQMTTNGFDPFEWRSFYFPGMSREEAHKLLGEPQVSIGTFLMRDSSRPGEYSLTVREAD 86 Query: 204 YGKTVYHYLISQ-------DKAGKYCIPEGTKFDTLWQLVEYLKL 241 G V HYLI + A I F + L+ + K+ Sbjct: 87 EGNAVCHYLIERGEPKEDGTAAAGVKIA-NQSFPDIPALLNHFKM 130 Score = 56.6 bits (135), Expect = 3e-08, Method: Composition-based stats. Identities = 36/155 (23%), Positives = 50/155 (32%), Gaps = 20/155 (12%) Query: 3 DPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLV---HDVRFHHF 59 DP F++ +SR EA + L ++ G FL+R R G Y L++ H+ Sbjct: 36 DPFEWRSFYFPGMSREEAHKLLGEPQVSIGTFLMRDSSR-PGEYSLTVREADEGNAVCHY 94 Query: 60 PIER-------QLNGTYAIAGGKAHCGPAELCEFYSRD--PDGLPCNLRKPCNRP----- 105 IER IA PA L F R L +KP Sbjct: 95 LIERGEPKEDGTAAAGVKIANQSFPDIPALLNHFKMRVLTEASLLAAYKKPIIEVVVGTF 154 Query: 106 --SGLEPQPGVFDCLRDAMVRDYVRQTWKLEGEAL 138 +G F+ + Q W AL Sbjct: 155 KFTGERETDLPFEQGERLEILSKTNQDWWEARNAL 189 >1RPY-A nrPDB Length = 114 Score = 59.2 bits (142), Expect = 5e-09, Method: Composition-based stats. Identities = 16/84 (19%), Positives = 39/84 (46%), Gaps = 3/84 (3%) Query: 161 MPWYHSSLTREEAERKLYSGAQT-DGKFLLRPRKE-QGTYALSLIYGKTVYHYLISQDKA 218 PW+H +L+R +A + + +G G F++R + G L+ + H +S + Sbjct: 11 YPWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTFNFQGKAKHLRLSLNGH 70 Query: 219 GKYCIPEGTKFDTLWQLVEYLKLK 242 G+ + + F +++ ++ + Sbjct: 71 GQCHV-QHLWFQSVFDMLRHFHTH 93 Score = 58.1 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 19/81 (23%), Positives = 36/81 (44%), Gaps = 1/81 (1%) Query: 9 PFFYGSISRAEAEEHLKLAG-MADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNG 67 P+F+G++SR +A + + G + GLF++RQ G VL+ + H + +G Sbjct: 12 PWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTFNFQGKAKHLRLSLNGHG 71 Query: 68 TYAIAGGKAHCGPAELCEFYS 88 + L F++ Sbjct: 72 QCHVQHLWFQSVFDMLRHFHT 92 >4AZW-A nrPDB Length = 471 Score = 59.2 bits (142), Expect = 5e-09, Method: Composition-based stats. Identities = 33/139 (23%), Positives = 53/139 (38%), Gaps = 18/139 (12%) Query: 349 FGS--VRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQ----LDNPYIVRLI 402 FG V + Y I A + + E+ E + + Q D P ++ Sbjct: 258 FGEDYVCKFFYYDMPHGILTA------EESQRNKHELHNEIKFLTQPPAGFDAPAVLA-H 310 Query: 403 GVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 G LVME G L L + ++L + + LE+K F H D+ Sbjct: 311 GENAQSG-WLVMEKLPGRLLSDMLAA----GEEIDREKILGSLLRSLAALEKKGFWHDDV 365 Query: 463 AARNVLLVNRHYAKISDFG 481 NV++ R +A++ DFG Sbjct: 366 RPWNVMVDARQHARLIDFG 384 >3CXL-A nrPDB Length = 463 Score = 58.5 bits (140), Expect = 8e-09, Method: Composition-based stats. Identities = 36/129 (27%), Positives = 61/129 (47%), Gaps = 22/129 (17%) Query: 126 YVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWY-----HSSLTREEAERKLYSG 180 Y + WK L+Q +AP ++ T E P Y H ++RE A++ L Sbjct: 15 YFQGVWKSYLYQLQQ----EAPHPRRITCTCEVENRPKYYGREFHGMISREAADQLLIVA 70 Query: 181 AQTDGKFLLRPRK-EQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYL 239 +G +L+R + + GTY L+L +G ++ + D GK+ + E +F+++ LV Sbjct: 71 ---EGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYD--GKHFVGEK-RFESIHDLV--- 121 Query: 240 KLKADGLIY 248 DGLI Sbjct: 122 ---TDGLIT 127 Score = 51.2 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 23/87 (26%), Positives = 36/87 (41%), Gaps = 12/87 (13%) Query: 11 FYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYA 70 F+G ISR A++ L +A+G +L+R+ R G Y L+L + +F + Sbjct: 54 FHGMISREAADQLLI---VAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFV- 109 Query: 71 IAGGKAHCGPAELCEFYSRDPDGLPCN 97 G K +L DGL Sbjct: 110 --GEKRFESIHDLV------TDGLITL 128 >2VIF-A nrPDB Length = 141 Score = 58.5 bits (140), Expect = 9e-09, Method: Composition-based stats. Identities = 24/80 (30%), Positives = 35/80 (43%), Gaps = 6/80 (7%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69 +++G I+R EAE KLA + DG FL+R LS + H IE NG + Sbjct: 26 WYWGPITRWEAEG--KLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEH-SNGRF 82 Query: 70 AIAGG---KAHCGPAELCEF 86 + + H +L E Sbjct: 83 SFYEQPDVEGHTSIVDLIEH 102 Score = 58.5 bits (140), Expect = 1e-08, Method: Composition-based stats. Identities = 23/83 (27%), Positives = 33/83 (39%), Gaps = 7/83 (8%) Query: 160 RMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTY--ALSLIYGKTVYHYLISQDK 217 + WY +TR EAE KL + DG FL+R Y +LS H I Sbjct: 23 KQGWYWGPITRWEAEGKLAN--VPDGSFLVRDS-SDDRYLLSLSFRSHGKTLHTRIEHSN 79 Query: 218 AG--KYCIPEGTKFDTLWQLVEY 238 Y P+ ++ L+E+ Sbjct: 80 GRFSFYEQPDVEGHTSIVDLIEH 102 >4CI6-B nrPDB Length = 643 Score = 58.1 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 32/181 (17%), Positives = 57/181 (31%), Gaps = 26/181 (14%) Query: 360 RKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL-DNPYIVRLIG---VCQAEALM--LV 413 + KQ VA K+ + E E+ I +P + + G V L+ Sbjct: 66 KDKQRLVA-KIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRYYYALL 124 Query: 414 MEMAGGGPLHKFLVGKREEIP---------VSNVAELLHQVSMGMKYLEEKNFVHRDLAA 464 M+ G L + + + H++ +L + VH D+ Sbjct: 125 MDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHNDIKP 184 Query: 465 RNVLLV-NRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC-INFRKFSSRSDV 522 NV+ + D GL + + + APE + S +SDV Sbjct: 185 GNVVFDRASGEPVVIDLGL--------HSRSGEQPKGFTESFKAPELGVGNLGASEKSDV 236 Query: 523 W 523 + Sbjct: 237 F 237 >6BHC-A nrPDB Length = 438 Score = 58.1 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 45/275 (16%), Positives = 92/275 (33%), Gaps = 49/275 (17%) Query: 352 VRQGVYRMRKKQIDVAIKVLKQGTEKAD--------TEEMMREAQIMHQLDN-----PYI 398 V + + A+K+ K +++ + + I + P Sbjct: 72 VYYTASYAKDPLNNYAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPN- 130 Query: 399 VRLIGV-----CQAEALMLVMEMAGGGPLHKFL------VGKREEIPVSNVAELLHQVSM 447 RL+ Q ++++ + F+ GK ++ V LL Q+ Sbjct: 131 -RLLPWEDPSKKQRSHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCS 189 Query: 448 GMKYLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLS----------KALGADDSYYT 494 G+++L+ + H DL N+LLV+ A+ FG + + + ++ S Sbjct: 190 GLEHLKPYHVTHCDLRLENLLLVHYQPGGTAQ--GFGPAEPTPTSSYPTRLIVSNFSQAK 247 Query: 495 ARSAGKWPL-----KWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVM 549 +S P APE I ++ + D + G+ ++E L P+ + + Sbjct: 248 QKSHLVDPEILRDQSRLAPEIITATQY-KKCDEFQTGILIYEMLHL-PNPFDENPELKER 305 Query: 550 AFIEQGK-RMECPPECPPELYALMSDCWIYKWEDR 583 + R+ L L S +R Sbjct: 306 EYTRADLPRIPFRSPYSRGLQQLASCLLNPNPSER 340 >4AZV-A nrPDB Length = 569 Score = 58.1 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 32/139 (23%), Positives = 53/139 (38%), Gaps = 18/139 (12%) Query: 349 FGS--VRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQ----LDNPYIVRLI 402 FG V + Y I A + + E+ E + + Q D P ++ Sbjct: 258 FGEDYVCKFFYYDMPHGILTA------EESQRNKYELHNEIKFLTQPPAGFDAPAVLA-H 310 Query: 403 GVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462 G LVME G L L + ++L + + LE++ F H D+ Sbjct: 311 GENAQSG-WLVMEKLPGRLLSDMLAA----GEEIDREKILGSLLRSLAALEKQGFWHDDV 365 Query: 463 AARNVLLVNRHYAKISDFG 481 NV++ R +A++ DFG Sbjct: 366 RPWNVMVDARQHARLIDFG 384 >1XA6-A nrPDB Length = 466 Score = 57.7 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 35/130 (26%), Positives = 62/130 (47%), Gaps = 22/130 (16%) Query: 125 DYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSS-----LTREEAERKLYS 179 +Y WK L+Q +AP+ +++I E P Y+ ++RE+A+ L Sbjct: 18 EYQPPIWKSYLYQLQQ----EAPRPKRIICPREVENRPKYYGREFHGIISREQADELL-- 71 Query: 180 GAQTDGKFLLRPRK-EQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEY 238 +G ++LR + + G Y L+L +G +Y + D GK+ + E +F+++ LV Sbjct: 72 -GGVEGAYILRESQRQPGCYTLALRFGNQTLNYRLFHD--GKHFVGEK-RFESIHDLV-- 125 Query: 239 LKLKADGLIY 248 DGLI Sbjct: 126 ----TDGLIT 131 Score = 48.1 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 23/87 (26%), Positives = 36/87 (41%), Gaps = 12/87 (13%) Query: 11 FYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYA 70 F+G ISR +A+E L G +G ++LR+ R G Y L+L + ++ + Sbjct: 58 FHGIISREQADELL---GGVEGAYILRESQRQPGCYTLALRFGNQTLNYRLFHDGKHFV- 113 Query: 71 IAGGKAHCGPAELCEFYSRDPDGLPCN 97 G K +L DGL Sbjct: 114 --GEKRFESIHDLV------TDGLITL 132 >6M7Z-A nrPDB Length = 319 Score = 55.8 bits (133), Expect = 6e-08, Method: Composition-based stats. Identities = 35/243 (14%), Positives = 77/243 (31%), Gaps = 35/243 (14%) Query: 362 KQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGP 421 + + ++++ K E +I+ + +P ++ +G + L + G Sbjct: 74 EGVSAKVRLINLLDPKYSVYEPYLYREILPK-RSPLLLPSLGEYRGAFLTYIFHPLSKGL 132 Query: 422 LHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFG 481 + L R +V L + +K L +HR + + ++ + Sbjct: 133 VGDMLETGRSH---PDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDGTVVLGGLD 189 Query: 482 LSKALGADDSYYTARSAGKWPLKWYAPEC---------INFRKFSSRSDVWSYGVT---M 529 + +G + + + APE + + + +SDV+S GV + Sbjct: 190 TAAPIGTETRLWVGFFGQET-----APEIDRNFLADLALTQGRHTVKSDVYSLGVAFRNL 244 Query: 530 WEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTV 589 + L G GPE + Q L L + +RP + Sbjct: 245 VQLLGNGNL------GPEDRGAVRQDH--------LELLDKLSQKMIEEEPGNRPTIEEI 290 Query: 590 EQR 592 + Sbjct: 291 MKD 293 >5VE6-A nrPDB Length = 492 Score = 54.6 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 16/70 (22%), Positives = 30/70 (42%), Gaps = 6/70 (8%) Query: 406 QAEALMLVMEMAGGGPLHKFLVGK------REEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 + + ++++ F+ E V LL Q+ G+++L+E +H Sbjct: 172 EQDCVVVITREVPHQTASDFVRDSAASHQAEPEAYERRVCFLLLQLCNGLEHLKEHGIIH 231 Query: 460 RDLAARNVLL 469 RDL N+LL Sbjct: 232 RDLCLENLLL 241 Score = 40.8 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 22/116 (18%), Positives = 45/116 (38%), Gaps = 15/116 (12%) Query: 506 YAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI-EQGKRMECPPEC 564 APE ++ ++ + D + G+ ++E L + EV A + E+ R E P Sbjct: 325 LAPEIVSASQY-RKFDEFQTGILIYELL-------HQPNPFEVRAQLRERDYRQEDLPPL 376 Query: 565 P------PELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKA 614 P P L L R ++ ++ + ++ PG++++A Sbjct: 377 PALSLYSPGLQQLAHLLLEADPIKRIRIGEAKRVLQCLLWGPRRELVQQPGTSEEA 432 >6G38-A nrPDB Length = 357 Score = 50.0 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 34/173 (19%), Positives = 61/173 (35%), Gaps = 54/173 (31%) Query: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-------QGTEKADTEEMMREAQIMHQL-- 393 ++G G FG V Q + VAIK++ G+ + EE++ E I +L Sbjct: 48 KIGEGVFGEVFQTIADHT----PVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSL 103 Query: 394 ---------------DNPYIVR------LI-----------------GVCQAEALMLVME 415 ++ + V+ L+ + + L +V+E Sbjct: 104 LSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLE 163 Query: 416 MAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLE-EKNFVHRDLAARNV 467 GG + + ++ +LHQ++ + E F HRDL NV Sbjct: 164 FEFGG--IDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNV 214 >6C7Y-B nrPDB Length = 117 Score = 49.2 bits (116), Expect = 5e-06, Method: Composition-based stats. Identities = 23/97 (23%), Positives = 39/97 (40%), Gaps = 3/97 (3%) Query: 144 SQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTY-ALSL 202 SQA A++ + +Y LT A KL S +G FL+R ++ + A+S+ Sbjct: 9 SQADFSSITRASSLLDACGFYWGPLTVSAAHEKLKSE--PEGTFLIRDSTQKNCFFAISV 66 Query: 203 IYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYL 239 I+ FD L++L+E+ Sbjct: 67 KTATGPTSIRINFQTGRFSLDGSKETFDCLFKLLEHY 103 Score = 47.7 bits (112), Expect = 2e-05, Method: Composition-based stats. Identities = 23/93 (24%), Positives = 39/93 (41%), Gaps = 5/93 (5%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69 F++G ++ + A E LK +G FL+R + + +S+ I Q G + Sbjct: 28 FYWGPLTVSAAHEKLKSE--PEGTFLIRDSTQKNCFFAISVKTATGPTSIRINFQT-GRF 84 Query: 70 AIAG-GKAHCGPAELCEFY-SRDPDGLPCNLRK 100 ++ G + +L E Y S L LRK Sbjct: 85 SLDGSKETFDCLFKLLEHYLSSPRKVLVTPLRK 117 >3ENH-A nrPDB Length = 540 Score = 48.5 bits (114), Expect = 8e-06, Method: Composition-based stats. Identities = 42/213 (19%), Positives = 75/213 (35%), Gaps = 41/213 (19%) Query: 292 YTPEPARITSPDKPRPMP-MDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFG 350 + R S D+ + +P T + E + +E+K KK + +G G Sbjct: 300 LMHKNGRWMSLDETKIIPNYRTDMVEVNWI--KEIKGKKRKIPEHL-------IGKGAEA 350 Query: 351 SVRQGVYRMRKKQIDVAIK-VLKQG------TEKADTEEMMREAQIMHQLDN-----PYI 398 +++ Y DV IK +K+G E REA+ + + + PYI Sbjct: 351 DIKRDSYLD----FDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKDFGIPAPYI 406 Query: 399 VRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 V ++ M G + ++ +++ + L + + + Sbjct: 407 ---FDVDLDNKRIM-MSYINGKLAKDVIEDN---------LDIAYKIGEIVGKLHKNDVI 453 Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKALGADDS 491 H DL N + Y I DFGL K D+ Sbjct: 454 HNDLTTSNFIFDKDLY--IIDFGLGKISNLDED 484 >6C5X-D nrPDB Length = 164 Score = 46.9 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 23/98 (23%), Positives = 38/98 (38%), Gaps = 5/98 (5%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69 F++G + A + LK G FL+R + + +S+ I+ G + Sbjct: 32 FYWGPMDVNVAHDKLKSE--PIGTFLIRDSKQKNCFFAISVKTARETVSIRIKFHA-GKF 88 Query: 70 AIAG-GKAHCGPAELCEFYSRDP-DGLPCNLRKPCNRP 105 ++ G + +L E Y P L LRK RP Sbjct: 89 SLDGSKELFSCLFQLVEHYMTSPKKMLVSPLRKVRLRP 126 Score = 45.8 bits (107), Expect = 6e-05, Method: Composition-based stats. Identities = 22/86 (25%), Positives = 38/86 (44%), Gaps = 5/86 (5%) Query: 164 YHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTY-ALSLIYGKTVYHYLISQDKAGKYC 222 Y + A KL S G FL+R K++ + A+S+ + I + AGK+ Sbjct: 33 YWGPMDVNVAHDKLKSE--PIGTFLIRDSKQKNCFFAISVKTARETVSIRI-KFHAGKFS 89 Query: 223 IPEGTK-FDTLWQLVEYLKLKADGLI 247 + + F L+QLVE+ ++ Sbjct: 90 LDGSKELFSCLFQLVEHYMTSPKKML 115 >4JGH-A nrPDB Length = 173 Score = 46.5 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 21/86 (24%), Positives = 36/86 (41%), Gaps = 13/86 (15%) Query: 163 WYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTY--ALSLIYGKTVYHYLISQDKAGK 220 WY S+T EA+ KL +G FL+R Y +S+ + I + GK Sbjct: 23 WYWGSMTVNEAKEKLKEA--PEGTFLIRDSSHS-DYLLTISVKTSAGPTNLRIEY-QDGK 78 Query: 221 YCIPEG-------TKFDTLWQLVEYL 239 + + +FD++ L++Y Sbjct: 79 FRLDSIICVKSKLKQFDSVVHLIDYY 104 Score = 43.1 bits (100), Expect = 4e-04, Method: Composition-based stats. Identities = 21/87 (24%), Positives = 38/87 (43%), Gaps = 10/87 (11%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69 +++GS++ EA+E LK A +G FL+R S +S+ + IE Q +G + Sbjct: 23 WYWGSMTVNEAKEKLKEA--PEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQ-DGKF 79 Query: 70 AIAG-------GKAHCGPAELCEFYSR 89 + K L ++Y + Sbjct: 80 RLDSIICVKSKLKQFDSVVHLIDYYVQ 106 >1TQM-A nrPDB Length = 282 Score = 45.0 bits (105), Expect = 9e-05, Method: Composition-based stats. Identities = 30/181 (16%), Positives = 65/181 (35%), Gaps = 29/181 (16%) Query: 349 FGSVRQGVYRMRKKQIDVAIKVLKQGTEKAD-------TEEMMREAQIMHQLDNPYIVRL 401 FG +++ K +K+ + D E + + +L + ++ Sbjct: 114 FGECVVKFHKVGHTSF----KKVKEKRDYGDLHFSVLAIRSARNEFRALQKLQGLAVPKV 169 Query: 402 IGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRD 461 E ++ME+ L++ R E P + +L +V+ + + VH D Sbjct: 170 YAW---EGNAVLMELIDAKELYRV----RVENPDEVLDMILEEVAK---FYH-RGIVHGD 218 Query: 462 LAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSD 521 L+ NVL+ I DF S +G + + + +++ R + + D Sbjct: 219 LSQYNVLVSEEG-IWIIDFPQSVEVGEEGWREILERDVRNIITYFS------RTYRTEKD 271 Query: 522 V 522 + Sbjct: 272 I 272 >6R5K-O nrPDB Length = 689 Score = 44.2 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 12/104 (11%), Positives = 37/104 (35%), Gaps = 8/104 (7%) Query: 362 KQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEAL-----MLVMEM 416 +K L + + ++ + QI +++ +++ + Q LV + Sbjct: 318 DGKAYVLKRLPNIDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGDLSICLVFDY 377 Query: 417 AGGG-PLHKFLVGKREEIPV--SNVAELLHQVSMGMKYLEEKNF 457 L+ + + P+ + + L Q++ + + +N Sbjct: 378 YPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNL 421 >2CR4-A nrPDB Length = 126 Score = 43.8 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 16/77 (20%), Positives = 28/77 (36%), Gaps = 7/77 (9%) Query: 172 EAERKLY----SGAQTDGKFLLRPRKEQGTYALSLIYG--KTVYHYLISQDKAGKYCIPE 225 E ER G DG + +R + L + V +Y I +K K+ + Sbjct: 28 EVERLFKATSPRGEPQDGLYCIRNSSTKSGKVLVVWDETSNKVRNYRI-FEKDSKFYLEG 86 Query: 226 GTKFDTLWQLVEYLKLK 242 F ++ +VE+ Sbjct: 87 EVLFVSVGSMVEHYHTH 103 >4XR7-L nrPDB Length = 465 Score = 43.8 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 12/104 (11%), Positives = 37/104 (35%), Gaps = 8/104 (7%) Query: 362 KQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEAL-----MLVMEM 416 +K L + + ++ + QI +++ +++ + Q LV + Sbjct: 94 DGKAYVLKRLPNIDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGDLSICLVFDY 153 Query: 417 AGGG-PLHKFLVGKREEIPV--SNVAELLHQVSMGMKYLEEKNF 457 L+ + + P+ + + L Q++ + + +N Sbjct: 154 YPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNL 197 >4CYJ-A nrPDB Length = 438 Score = 43.5 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 19/141 (13%), Positives = 51/141 (36%), Gaps = 17/141 (12%) Query: 352 VRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQ----- 406 V + + + A++ L +G + + ++ + ++ N IV + V Sbjct: 71 VYKA--QNSRNGRHYALRRL-EGYRLTNEKAILNVMKDWKKIKNASIVTIHEVFTTREFG 127 Query: 407 AEALMLVMEMAGGG-PLHKF----LVGKREEIP----VSNVAELLHQVSMGMKYLEEKNF 457 +L+ + L + + G R P + + + Q++ +K + Sbjct: 128 DSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTIHSNRL 187 Query: 458 VHRDLAARNVLLVNRHYAKIS 478 R L ++L + + ++S Sbjct: 188 AARCLEPSKIILTDINRIRLS 208 >4Z32-A nrPDB Length = 497 Score = 43.5 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 25/99 (25%), Positives = 38/99 (38%), Gaps = 8/99 (8%) Query: 12 YGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDV----RFHHFPIERQLNG 67 +G IS A LK AG GL++LR + Y L+ + + H I + N Sbjct: 372 HGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENE 431 Query: 68 TYAIAG-GKAHCGPAELCEFYSRD---PDGLPCNLRKPC 102 Y ++G K +L Y + D + K C Sbjct: 432 EYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCC 470 >4GL9-E nrPDB Length = 143 Score = 43.1 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 22/113 (19%), Positives = 42/113 (37%), Gaps = 9/113 (7%) Query: 134 EGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRK 193 +G + S++ + A + +Y S++T EA L S G FL+R Sbjct: 1 QGAHDLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEA-NLLLSAEPA-GTFLIRDSS 58 Query: 194 EQGT-YALSLIYGKTVYHYLISQDKAGKYCIPEGT------KFDTLWQLVEYL 239 +Q + LS+ + I + + +FD + +LV + Sbjct: 59 DQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHY 111 Score = 39.2 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 16/86 (18%), Positives = 33/86 (38%), Gaps = 10/86 (11%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69 F++ +++ EA L L+ G FL+R + LS+ + I+ + G++ Sbjct: 30 FYWSAVTGGEAN--LLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEG-GSF 86 Query: 70 AIAGGKAHCGPA-------ELCEFYS 88 ++ P +L Y Sbjct: 87 SLQSDPRSTQPVPRFDCVLKLVHHYM 112 >2HMH-A nrPDB Length = 152 Score = 43.1 bits (100), Expect = 4e-04, Method: Composition-based stats. Identities = 20/93 (21%), Positives = 35/93 (37%), Gaps = 9/93 (9%) Query: 154 ATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGT-YALSLIYGKTVYHYL 212 A + +Y S++T EA L S G FL+R +Q + LS+ + Sbjct: 27 AVRKLQESGFYWSAVTGGEA-NLLLSAEPA-GTFLIRDSSDQRHFFTLSVKTQSGTKNLR 84 Query: 213 ISQDKAGKYCIPEGT------KFDTLWQLVEYL 239 I + + +FD + +LV + Sbjct: 85 IQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHY 117 Score = 39.2 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 16/86 (18%), Positives = 33/86 (38%), Gaps = 10/86 (11%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69 F++ +++ EA L L+ G FL+R + LS+ + I+ + G++ Sbjct: 36 FYWSAVTGGEAN--LLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEG-GSF 92 Query: 70 AIAGGKAHCGPA-------ELCEFYS 88 ++ P +L Y Sbjct: 93 SLQSDPRSTQPVPRFDCVLKLVHHYM 118 >2BBU-A nrPDB Length = 164 Score = 42.7 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 23/116 (19%), Positives = 42/116 (36%), Gaps = 12/116 (10%) Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69 F++ +++ EA L L+ G FL+R + LS+ + I+ + G++ Sbjct: 25 FYWSAVTGGEAN--LLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEG-GSF 81 Query: 70 AIAGGKAHCGPA-------ELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCL 118 ++ P +L Y P +L P PS P+ L Sbjct: 82 SLQSDPRSTQPVPRFDCVLKLVHHYMPPPGTPSFSL--PPTEPSSEVPEQPPAQAL 135 Score = 42.7 bits (99), Expect = 5e-04, Method: Composition-based stats. Identities = 20/93 (21%), Positives = 35/93 (37%), Gaps = 9/93 (9%) Query: 154 ATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGT-YALSLIYGKTVYHYL 212 A + +Y S++T EA L S G FL+R +Q + LS+ + Sbjct: 16 AVRKLQESGFYWSAVTGGEA-NLLLSAEPA-GTFLIRDSSDQRHFFTLSVKTQSGTKNLR 73 Query: 213 ISQDKAGKYCIPEGT------KFDTLWQLVEYL 239 I + + +FD + +LV + Sbjct: 74 IQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHY 106 >3MAZ-A nrPDB Length = 125 Score = 41.9 bits (97), Expect = 8e-04, Method: Composition-based stats. Identities = 16/92 (17%), Positives = 37/92 (40%), Gaps = 5/92 (5%) Query: 161 MPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYG---KTVYHYLISQDK 217 MP +++R+EA L + G +LRP + Y++++ + HY + Sbjct: 15 MPACFYTVSRKEATEML-QKNPSLGNMILRPGSDSRNYSITIRQEIDIPRIKHYKVMSVG 73 Query: 218 AGKYC-IPEGTKFDTLWQLVEYLKLKADGLIY 248 + + L+ +++Y + G + Sbjct: 74 QNYTIELEKPVTLPNLFSVIDYFVKETRGNLR 105 >4WWA-A nrPDB Length = 261 Score = 41.5 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 21/75 (28%), Positives = 31/75 (41%), Gaps = 7/75 (9%) Query: 415 EMAGGG----PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLV 470 E GG L FL ++ VA L +V + L ++ H DL + N++LV Sbjct: 111 EDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDYCHGDLTSSNIVLV 170 Query: 471 NRH---YAKISDFGL 482 + DFGL Sbjct: 171 RDGARWTPHLIDFGL 185 >4BWP-A nrPDB Length = 448 Score = 40.8 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 15/140 (10%), Positives = 41/140 (29%), Gaps = 39/140 (27%) Query: 353 RQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQ-----A 407 + + ++ + ++ + E + +L + +V+L V Sbjct: 67 YRATHNTTG--YKYCLRRIHGFRLQSTKCMTLVE--MWKKLQHTNVVQLREVFTTKAFGD 122 Query: 408 EALMLVMEMAGGG--PLHKFL----------------------------VGKREEIPVSN 437 +L+LV + G L K+ +P + Sbjct: 123 NSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEAT 182 Query: 438 VAELLHQVSMGMKYLEEKNF 457 + ++ Q++ G+K + Sbjct: 183 IWSIIMQLTAGLKAIHHAGL 202 >2IZV-A nrPDB Length = 187 Score = 40.4 bits (93), Expect = 0.003, Method: Composition-based stats. Identities = 21/83 (25%), Positives = 32/83 (38%), Gaps = 5/83 (6%) Query: 9 PFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIER-QLNG 67 P ++G + + AE L G +G FLLR + + +S R H IE+ N Sbjct: 35 PCYWGVMDKYAAEALL--EGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNF 92 Query: 68 TYAIAGGKAHCGP--AELCEFYS 88 ++ P L E Y Sbjct: 93 SFDAHDPCVFHSPDITGLLEHYK 115 Score = 40.0 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 18/83 (21%), Positives = 34/83 (40%), Gaps = 6/83 (7%) Query: 162 PWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQG-TYALSLIYGKTVYHYLISQ-DKAG 219 P Y + + AE L + +G FLLR ++ +++S H I Q + Sbjct: 35 PCYWGVMDKYAAEALL--EGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNF 92 Query: 220 KYCIPEGTKFDT--LWQLVEYLK 240 + + F + + L+E+ K Sbjct: 93 SFDAHDPCVFHSPDITGLLEHYK 115 >4CZY-B nrPDB Length = 429 Score = 39.2 bits (90), Expect = 0.006, Method: Composition-based stats. Identities = 14/118 (11%), Positives = 37/118 (31%), Gaps = 22/118 (18%) Query: 382 EMMREAQIM------HQLDNPYIVRLIGVCQAE-----ALMLVMEMAGGGP-LHKFLV-- 427 + E I+ ++ N IV + E +L+ V + L+ Sbjct: 81 RLTNEKAILNVTKEWKKIINANIVTVHEAFTTEFFGDSSLIFVYDFHPLSETLYDHHFPP 140 Query: 428 -------GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKIS 478 +IP + + + Q++ + + R L + + + +++ Sbjct: 141 NNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAKLAARCLELSKI-IWENNRIRLA 197 >6G18-v nrPDB Length = 552 Score = 38.4 bits (88), Expect = 0.009, Method: Composition-based stats. Identities = 14/69 (20%), Positives = 27/69 (39%), Gaps = 7/69 (10%) Query: 412 LVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN 471 +VME+ G PL + + EL+ +++ +H D N++L Sbjct: 186 VVMELINGYPLCQIHHVEDPASVYDEAMELIVKLA-------NHGLIHGDFNEFNLILDE 238 Query: 472 RHYAKISDF 480 + + DF Sbjct: 239 SDHITMIDF 247 >6FDN-A nrPDB Length = 320 Score = 38.4 bits (88), Expect = 0.010, Method: Composition-based stats. Identities = 14/69 (20%), Positives = 27/69 (39%), Gaps = 7/69 (10%) Query: 412 LVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN 471 +VME+ G PL + + EL+ +++ +H D N++L Sbjct: 186 VVMELINGYPLCQIHHVEDPASVYDEAMELIVKLA-------NHGLIHGDFNEFNLILDE 238 Query: 472 RHYAKISDF 480 + + DF Sbjct: 239 SDHITMIDF 247 >1UUS-A nrPDB Length = 473 Score = 38.1 bits (87), Expect = 0.012, Method: Composition-based stats. Identities = 16/99 (16%), Positives = 36/99 (36%), Gaps = 15/99 (15%) Query: 12 YGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLS---LVHDVRFHHFPIERQLNGT 68 YG + R E + L G F++R R+ G + ++ + R H+ ++ Sbjct: 355 YGYMGRQEVNDAL--QNQDPGTFIIRFSERNPGQFGIAYIGVEMPARIKHYLVQPNDTAA 412 Query: 69 YA------IAGGKAHCGPAELCEFYSRDPDGLPCNLRKP 101 ++ + +++D +G P L+ Sbjct: 413 AKKTFPDFLSEHSQFVNLLQ----WTKDTNGAPRFLKLH 447 >3BYV-A nrPDB Length = 377 Score = 37.3 bits (85), Expect = 0.021, Method: Composition-based stats. Identities = 32/178 (17%), Positives = 56/178 (31%), Gaps = 33/178 (18%) Query: 438 VAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARS 497 +L QV + L VH L +++L R ++ F + L D AR Sbjct: 208 RLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGF---EHLVRDG----ARV 260 Query: 498 AGKWPLKWYAPECINFR---KF--------SSRSDVWSYGVTMWEALSYGQKPYKKMKGP 546 + PE R + + D W+ G+ ++ P K Sbjct: 261 VSSVSRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIWCA-DLPITKDAAL 319 Query: 547 EVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDR---------PDFLTVEQRMRA 595 +I + + P + AL+ Y EDR P++ + + A Sbjct: 320 GGSEWIFRSCK-----NIPQPVRALLEGFLRYPKEDRLLPLQAMETPEYEQLRTELSA 372 >2W1Z-A nrPDB Length = 368 Score = 36.9 bits (84), Expect = 0.029, Method: Composition-based stats. Identities = 28/151 (18%), Positives = 52/151 (34%), Gaps = 13/151 (8%) Query: 438 VAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARS 497 +L Q+ L+ VH D RN+LL R ++ G + S + Sbjct: 193 RLQLTLQLIRLAASLQHYGLVHADFQVRNILLDQRGGVFLT--GFEHLVRDGASAVSPIG 250 Query: 498 AGKWPLKWYAPECINFRKF-----SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI 552 G P + A + +R+ + D W+ G+ ++ + + + Sbjct: 251 RGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWIWCADLPNTEDAELGGIEWIY 310 Query: 553 EQGKRMECPPECPPELYALMSDCWIYKWEDR 583 + K + P + AL+ Y EDR Sbjct: 311 RRCKNIPQP------VRALLEGFLRYSKEDR 335 >3DZO-A nrPDB Length = 413 Score = 36.1 bits (82), Expect = 0.050, Method: Composition-based stats. Identities = 29/172 (16%), Positives = 55/172 (31%), Gaps = 22/172 (12%) Query: 438 VAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARS 497 +L QV + L VH L +++L R ++ G + S + Sbjct: 213 RLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLT--GFEHLVRDGASAVSPIG 270 Query: 498 AGKWPLKWYAPECINFRKF-----SSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI 552 G P + A + F + + D W+ G+ ++ P +I Sbjct: 271 RGFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCA-DLPNTDDAALGGSEWI 329 Query: 553 EQGKRMECPPECPPELYALMSDCWIYKWEDR---------PDFLTVEQRMRA 595 + + P + AL+ Y EDR P++ + + A Sbjct: 330 FRSCK-----NIPQPVRALLEGFLRYPKEDRLLPLQAMETPEYEQLRTELSA 376 >5YK0-A nrPDB Length = 452 Score = 35.4 bits (80), Expect = 0.070, Method: Composition-based stats. Identities = 49/301 (16%), Positives = 88/301 (29%), Gaps = 52/301 (17%) Query: 224 PEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRR 283 K ++ V + A GL L + + AA L L + Sbjct: 20 ARNAKLASIP--VGFAGRAALGLGKRLTGKSKDEVTAELMEKAANQLFTVLGELKGGAMK 77 Query: 284 IDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLK-RDNLL-IAD 341 + S P P + + P S + D +L K R+ D Sbjct: 78 VGQALSVMEAAIPDEFGEPYREALTKLQKDAPPLPASKVHRVLDGQLGTKWRERFSSFND 137 Query: 342 IELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTE---KADTEEMMREAQIMHQL----- 393 + + G V + ++ +VA+K+ G + +AD + M R ++ QL Sbjct: 138 TPVASASIGQVHKAIW---SDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGAD 194 Query: 394 ---------------------------------DNPYIVRLIGVCQAEALMLVMEMAGGG 420 D+P ++ V + +++ E G Sbjct: 195 VQGVVDELVERTEMELDYRLEAANQRAFAKAYHDHPRF-QVPHVVASAPKVVIQEWIEGV 253 Query: 421 PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDF 480 P+ + + E L + L +H D N +L+ I DF Sbjct: 254 PMAEIIRHGTTEQRDLIGTLLAELTFDAPRRL---GLMHGDAHPGNFMLLPDGRMGIIDF 310 Query: 481 G 481 G Sbjct: 311 G 311 >5IXI-A nrPDB Length = 544 Score = 34.6 bits (78), Expect = 0.14, Method: Composition-based stats. Identities = 20/120 (16%), Positives = 41/120 (34%), Gaps = 19/120 (15%) Query: 12 YGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLV----------HDVRFHHFPI 61 +G I A L+ G +G+++LR ++++ +F +F I Sbjct: 423 HGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQI 482 Query: 62 ERQLNGTYAIAGGKAHCGPAELCEFYSRD---PDGLPCNLRKPCNRPSGLEPQPGVFDCL 118 E Q ++ +L + D + L++ C +P+P L Sbjct: 483 EVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCC------QPKPREISNL 536 >4H05-A nrPDB Length = 273 Score = 34.6 bits (78), Expect = 0.15, Method: Composition-based stats. Identities = 17/57 (29%), Positives = 21/57 (36%), Gaps = 3/57 (5%) Query: 457 FVHRDLAARNVLLVNR-HYAK-ISDFG-LSKALGADDSYYTARSAGKWPLKWYAPEC 510 H DL NVLL R + D G + +A D R W+ PEC Sbjct: 186 VCHGDLCPDNVLLDPRTCEVTGLIDVGRVGRADRHSDLALVLRELAHEEDPWFGPEC 242 >1Y3T-A nrPDB Length = 337 Score = 33.4 bits (75), Expect = 0.28, Method: Composition-based stats. Identities = 20/127 (15%), Positives = 37/127 (29%), Gaps = 12/127 (9%) Query: 15 ISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIER------QLNGT 68 ++ + + DG F++ G ++ H+ F Sbjct: 199 LTGDQLHRIVAAQKNTDGQFIVVSSEGPKGDRIVDHYHEYHTETFYCLEGQMTMWTDGQE 258 Query: 69 YAIAGGKAHCGPAELCE------FYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAM 122 + G PA Y++ L L +P R G + +F C A+ Sbjct: 259 IQLNPGDFLHVPANTVHSYRLDSHYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCKPQAL 318 Query: 123 VRDYVRQ 129 D + Q Sbjct: 319 RFDRILQ 325 Score = 30.7 bits (68), Expect = 1.9, Method: Composition-based stats. Identities = 18/121 (14%), Positives = 36/121 (29%), Gaps = 17/121 (14%) Query: 168 LTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYHY--------------L 212 LT ++ R + + TDG+F++ + G + + + Sbjct: 199 LTGDQLHRIVAAQKNTDGQFIVVSSEGPKGDRIVDHYHEYHTETFYCLEGQMTMWTDGQE 258 Query: 213 ISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPA 272 I + +P T ++L + L+ L E + G P P Sbjct: 259 IQLNPGDFLHVPANTVHS--YRLDSHYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCKPQ 316 Query: 273 H 273 Sbjct: 317 A 317 >3Q60-A nrPDB Length = 371 Score = 33.4 bits (75), Expect = 0.32, Method: Composition-based stats. Identities = 27/196 (13%), Positives = 61/196 (31%), Gaps = 26/196 (13%) Query: 423 HKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGL 482 F+ R + + + L Q+ L+ K VH N+ ++ + D Sbjct: 181 LDFVYVFRGDEGILALHILTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGD--- 237 Query: 483 SKALGADDSYYTARSAGKWPLKWYAPECINFR--KFSSRSDVWSYGVTMWEALSYGQKPY 540 + A T A P+ + E +N F+ + W G++++ P+ Sbjct: 238 ---VSALWKVGTRGPASSVPVTYAPREFLNASTATFTHALNAWQLGLSIYRVWCL-FLPF 293 Query: 541 KKMKGPEVMAFIEQGKRMECPPE--------CPPELYALMSDCWIYKWEDR--------- 583 + ++ R+ P + L+ + R Sbjct: 294 GLVTPGIKGSWKRPSLRVPGTDSLAFGSCTPLPDFVKTLIGRFLNFDRRRRLLPLEAMET 353 Query: 584 PDFLTVEQRMRACYYS 599 P+FL ++ + + + Sbjct: 354 PEFLQLQNEISSSLST 369 >1FUI-A nrPDB Length = 591 Score = 30.7 bits (68), Expect = 2.0, Method: Composition-based stats. Identities = 16/61 (26%), Positives = 25/61 (40%), Gaps = 5/61 (8%) Query: 466 NVLLVNRHYAKISDFGLSKALGAD-DSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWS 524 N++ +I++ G S L D R+ WP W+AP F+ DV+S Sbjct: 464 NIIKGLGPVLQIAE-GWSVELPKDVHDILNKRTNSTWPTTWFAPRLTGKGPFT---DVYS 519 Query: 525 Y 525 Sbjct: 520 V 520 >4BVU-A nrPDB Length = 211 Score = 30.4 bits (67), Expect = 2.3, Method: Composition-based stats. Identities = 15/84 (17%), Positives = 26/84 (30%), Gaps = 17/84 (20%) Query: 401 LIGVCQAEALMLVMEM----------AGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMK 450 L + +V++ G PL +IP + + L + Sbjct: 90 LFNAFYGDEASVVIQYGGDVYLRMLRVPGTPLSDIDTA---DIPDNIESLYLQLICK--- 143 Query: 451 YLEEKNFVHRDLAARNVLLVNRHY 474 L E + +H DL N+L Sbjct: 144 -LNELSIIHYDLNTGNMLYDKESE 166 >5JY7-I nrPDB Length = 441 Score = 30.4 bits (67), Expect = 2.6, Method: Composition-based stats. Identities = 15/60 (25%), Positives = 27/60 (45%), Gaps = 9/60 (15%) Query: 367 AIKVLKQGTEKADTEEMMREA-QIMHQLDNPYIVRLIGVCQAE------ALMLVMEMAGG 419 AI L + ++ E +++ + NP++ RL+G + E AL +V E A Sbjct: 142 AIFKLFRRITPGVHPDI--ELNRVLARAGNPHVARLLGSFETEWEGEPYALGMVTEFAAN 199 >6EF6-A nrPDB Length = 354 Score = 30.0 bits (66), Expect = 3.0, Method: Composition-based stats. Identities = 7/28 (25%), Positives = 13/28 (46%), Gaps = 3/28 (10%) Query: 456 NFVHRDLAARNVLLVN---RHYAKISDF 480 +H DL N+L+ + + + DF Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >1BF5-A nrPDB Length = 575 Score = 30.0 bits (66), Expect = 3.3, Method: Composition-based stats. Identities = 23/121 (19%), Positives = 40/121 (33%), Gaps = 6/121 (4%) Query: 165 HSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIP 224 +++E L G FLLR + A++ + + + A + Sbjct: 444 MGFISKERERALLKDQQP--GTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTK 501 Query: 225 EGTKFDTLWQLVEYLKLKADGLIYC--LKEACPNSSASNASGA--AAPTLPAHPSTLTHP 280 + T ++ K+ A I LK PN +A G + P P L P Sbjct: 502 KELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGP 561 Query: 281 Q 281 + Sbjct: 562 K 562 >1Y1U-A nrPDB Length = 585 Score = 30.0 bits (66), Expect = 3.4, Method: Composition-based stats. Identities = 12/42 (28%), Positives = 20/42 (47%), Gaps = 2/42 (4%) Query: 13 GSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDV 54 G +++ +A + L DG FLLR +GG ++ D Sbjct: 469 GFVNKQQAHDLLI--NKPDGTFLLRFSDSEIGGITIAWKFDS 508 >2ZO6-A nrPDB Length = 254 Score = 29.6 bits (65), Expect = 4.2, Method: Composition-based stats. Identities = 16/82 (19%), Positives = 32/82 (39%), Gaps = 11/82 (13%) Query: 538 KPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACY 597 KPY+ ++ + +G + + +++ + C +D PD+ + C+ Sbjct: 63 KPYEGKH--KITLDVTKGGPLPFAFDLLSTVFSYGNRCLTKYPDDIPDY------FKQCF 114 Query: 598 ---YSLASKVEGPPGSTQKAEA 616 YS K E G A+A Sbjct: 115 PGGYSWERKFEFEDGGLAIAKA 136 >2CW7-A nrPDB Length = 537 Score = 29.6 bits (65), Expect = 4.2, Method: Composition-based stats. Identities = 16/76 (21%), Positives = 25/76 (32%), Gaps = 2/76 (2%) Query: 12 YGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYAI 71 G + R E L+++G+ F R L + HD + I + I Sbjct: 33 AGKVKREGETEVLEVSGLEVPSFNRRTNKAELKRVKALIRHDYSGKVYTIRLKSGRRIKI 92 Query: 72 AGGKAHCGP--AELCE 85 G + EL E Sbjct: 93 TSGHSLFSVRNGELVE 108 >2DIA-A nrPDB Length = 113 Score = 28.4 bits (62), Expect = 9.7, Method: Composition-based stats. Identities = 10/61 (16%), Positives = 24/61 (39%), Gaps = 1/61 (1%) Query: 15 ISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVR-FHHFPIERQLNGTYAIAG 73 +S + + + + DG + + + G Y L++ + HFP ++ + Sbjct: 49 VSDSGTKAEVSIQNNKDGTYAVTYVPLTAGMYTLTMKYGGELVPHFPARVKVEPAVDTSS 108 Query: 74 G 74 G Sbjct: 109 G 109 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.312 0.140 0.406 Lambda K H 0.267 0.0427 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 25,063,180 Number of Sequences: 36641 Number of extensions: 1061802 Number of successful extensions: 7245 Number of sequences better than 10.0: 555 Number of HSP's better than 10.0 without gapping: 914 Number of HSP's successfully gapped in prelim test: 139 Number of HSP's that attempted gapping in prelim test: 3238 Number of HSP's gapped (non-prelim): 1250 length of query: 619 length of database: 10,336,785 effective HSP length: 103 effective length of query: 516 effective length of database: 6,562,762 effective search space: 3386385192 effective search space used: 3386385192 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 62 (28.4 bits)