BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P43250 (576 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3NYO-A nrPDB 1189 0.0 4TNB-A nrPDB 817 0.0 4YHJ-A nrPDB 761 0.0 3C51-A nrPDB 485 e-137 3PVW-A nrPDB 321 6e-88 5UUU-A nrPDB 318 3e-87 2JDO-A nrPDB 218 7e-57 3MV5-A nrPDB 216 2e-56 4RA4-A nrPDB 212 4e-55 5KCV-A nrPDB 211 6e-55 3PFQ-A nrPDB 202 2e-52 2I0E-A nrPDB 201 5e-52 4L42-A nrPDB 199 4e-51 1VZO-A nrPDB 198 4e-51 3A8W-A nrPDB 198 5e-51 4RLP-A nrPDB 197 1e-50 5F9E-A nrPDB 192 4e-49 3HDN-A nrPDB 190 1e-48 2Z7Q-A nrPDB 190 1e-48 1FOT-A nrPDB 190 2e-48 5D9K-A nrPDB 188 4e-48 3TXO-A nrPDB 187 9e-48 4FR4-A nrPDB 181 5e-46 5X3F-B nrPDB 176 2e-44 5N23-A nrPDB 176 3e-44 4WB7-A nrPDB 175 5e-44 4OTD-A nrPDB 171 6e-43 4CRS-A nrPDB 169 4e-42 3ORZ-A nrPDB 162 3e-40 3TKU-A nrPDB 157 2e-38 5FET-A nrPDB 156 2e-38 2VD5-A nrPDB 156 2e-38 6ED6-A nrPDB 155 4e-38 6BDL-A nrPDB 152 4e-37 5DYK-A nrPDB 150 2e-36 4AW2-A nrPDB 150 2e-36 6E9W-A nrPDB 149 3e-36 5LOH-A nrPDB 147 9e-36 4C0T-A nrPDB 138 7e-33 2JC6-A nrPDB 135 7e-32 6BXI-A nrPDB 133 2e-31 5JN2-A nrPDB 131 8e-31 3MA6-A nrPDB 131 8e-31 4YZB-A nrPDB 127 1e-29 1KOB-A nrPDB 126 2e-29 2J90-A nrPDB 126 3e-29 4RGJ-A nrPDB 125 4e-29 2WQN-A nrPDB 125 5e-29 2Y7J-A nrPDB 124 8e-29 3DXN-A nrPDB 124 1e-28 3GUB-A nrPDB 124 1e-28 3HZT-A nrPDB 124 1e-28 1ZWS-A nrPDB 122 3e-28 2A27-A nrPDB 122 3e-28 2JAM-A nrPDB 122 4e-28 4FG9-A nrPDB 121 7e-28 3NCG-A nrPDB 120 1e-27 2YAB-A nrPDB 120 1e-27 3DFA-A nrPDB 120 2e-27 3TAC-A nrPDB 120 2e-27 2X4F-A nrPDB 119 3e-27 4B6L-A nrPDB 119 4e-27 5XZW-A nrPDB 117 1e-26 5FG8-A nrPDB 117 2e-26 4REW-A nrPDB 116 2e-26 4XBR-A nrPDB 116 3e-26 4RED-A nrPDB 115 4e-26 4FIE-A nrPDB 115 5e-26 4JDH-A nrPDB 115 5e-26 2Q0N-A nrPDB 115 5e-26 4CFH-A nrPDB 115 5e-26 3LIJ-A nrPDB 114 1e-25 4PDS-A nrPDB 114 1e-25 3D2K-A nrPDB 113 2e-25 3BHH-A nrPDB 113 2e-25 3KK8-A nrPDB 113 3e-25 3H4J-B nrPDB 112 3e-25 3MN3-A nrPDB 112 3e-25 2BDW-A nrPDB 112 4e-25 5ES1-A nrPDB 112 5e-25 4UZD-A nrPDB 112 5e-25 2V7O-A nrPDB 112 6e-25 4CFF-A nrPDB 111 7e-25 5EZV-A nrPDB 111 8e-25 2VN9-A nrPDB 111 9e-25 5IG1-A nrPDB 111 9e-25 2YZA-A nrPDB 110 1e-24 1PHK-A nrPDB 110 1e-24 5KZ7-A nrPDB 109 3e-24 5JZN-A nrPDB 108 5e-24 4B8L-A nrPDB 108 6e-24 5TQX-A nrPDB 108 6e-24 2OU7-A nrPDB 108 8e-24 4J52-A nrPDB 108 9e-24 2QNJ-A nrPDB 107 1e-23 2F57-A nrPDB 107 1e-23 4APC-A nrPDB 107 1e-23 3DB8-A nrPDB 107 2e-23 2VZ6-A nrPDB 107 2e-23 6C9D-A nrPDB 107 2e-23 6CMJ-A nrPDB 106 2e-23 4D28-A nrPDB 106 2e-23 4I6B-A nrPDB 106 3e-23 5U6Y-A nrPDB 106 3e-23 3UTO-A nrPDB 106 3e-23 2HAK-A nrPDB 106 3e-23 4LQP-A nrPDB 105 4e-23 1KOA-A nrPDB 105 4e-23 4JXF-A nrPDB 105 5e-23 3KN6-A nrPDB 105 5e-23 2YCR-A nrPDB 105 6e-23 4CZT-A nrPDB 105 8e-23 5YKS-A nrPDB 105 8e-23 3I6U-A nrPDB 104 1e-22 4CQG-A nrPDB 103 2e-22 4NIF-A nrPDB 103 2e-22 4KS7-A nrPDB 103 3e-22 3SOA-A nrPDB 102 3e-22 4YNZ-A nrPDB 102 3e-22 6FDY-U nrPDB 102 5e-22 3IS5-A nrPDB 102 5e-22 4KIK-B nrPDB 101 7e-22 2BPM-A nrPDB 101 8e-22 3Q5I-A nrPDB 101 1e-21 4WNO-A nrPDB 101 1e-21 3LM0-A nrPDB 101 1e-21 5YV8-A nrPDB 100 2e-21 3QA8-A nrPDB 99 5e-21 4D2V-A nrPDB 99 7e-21 1CM8-A nrPDB 98 1e-20 6FD3-A nrPDB 97 1e-20 4MVF-A nrPDB 96 4e-20 4AF3-A nrPDB 96 4e-20 3F3Z-A nrPDB 96 6e-20 5WAX-A nrPDB 94 1e-19 2W4O-A nrPDB 94 1e-19 6QAU-A nrPDB 94 1e-19 6CCF-A nrPDB 94 1e-19 3NIZ-A nrPDB 94 1e-19 5DBX-A nrPDB 94 1e-19 3Q53-A nrPDB 94 1e-19 3UC3-A nrPDB 94 2e-19 4JG6-A nrPDB 93 3e-19 3DAK-A nrPDB 92 6e-19 1TKI-A nrPDB 91 1e-18 3UDB-A nrPDB 91 1e-18 4AN9-A nrPDB 91 2e-18 4QMW-A nrPDB 90 2e-18 4KRC-A nrPDB 90 2e-18 5AIR-A nrPDB 90 3e-18 6HXF-B nrPDB 89 6e-18 4BGQ-A nrPDB 88 9e-18 6J5U-C nrPDB 88 9e-18 2XIK-A nrPDB 88 9e-18 5AWM-A nrPDB 88 1e-17 6CKI-A nrPDB 87 2e-17 3ZUT-A nrPDB 87 2e-17 2PMN-X nrPDB 87 2e-17 3E7O-A nrPDB 87 3e-17 5J5T-A nrPDB 86 3e-17 2HW6-A nrPDB 86 4e-17 5Y86-A nrPDB 86 5e-17 4NST-A nrPDB 86 5e-17 4FZF-B nrPDB 86 5e-17 3FXW-A nrPDB 86 6e-17 2BRG-A nrPDB 86 6e-17 4MYG-A nrPDB 85 7e-17 5HI2-A nrPDB 85 7e-17 3ZDU-A nrPDB 85 9e-17 3OHT-A nrPDB 85 9e-17 5ZTN-A nrPDB 85 1e-16 5HIE-A nrPDB 85 1e-16 1V0B-A nrPDB 84 1e-16 3FI2-A nrPDB 84 2e-16 3COM-A nrPDB 84 2e-16 1JNK-A nrPDB 84 2e-16 5EFQ-A nrPDB 84 2e-16 5KKR-C nrPDB 83 3e-16 3GC9-A nrPDB 83 3e-16 1UA2-A nrPDB 83 3e-16 1S9I-A nrPDB 82 4e-16 3EQC-A nrPDB 82 4e-16 5Z33-A nrPDB 82 5e-16 4EWQ-A nrPDB 82 5e-16 4EQM-A nrPDB 82 6e-16 4BBM-A nrPDB 82 7e-16 4HVI-A nrPDB 82 7e-16 3OMV-A nrPDB 82 9e-16 6AO5-A nrPDB 81 1e-15 5G6V-A nrPDB 81 1e-15 4LG4-A nrPDB 81 1e-15 3VN9-A nrPDB 81 1e-15 2UV2-A nrPDB 81 2e-15 2F9G-A nrPDB 80 2e-15 3FME-A nrPDB 80 3e-15 6DTL-A nrPDB 80 3e-15 3ALO-A nrPDB 80 3e-15 5L2Q-C nrPDB 80 3e-15 5TOS-A nrPDB 80 3e-15 6GU6-A nrPDB 80 3e-15 6CTH-A nrPDB 80 3e-15 1NY3-A nrPDB 79 5e-15 3KA0-A nrPDB 79 5e-15 2XS0-A nrPDB 79 5e-15 2OZA-A nrPDB 79 6e-15 5VD3-A nrPDB 79 6e-15 4IDT-A nrPDB 79 8e-15 5VO2-A nrPDB 78 1e-14 1G3N-A nrPDB 77 1e-14 5TUR-A nrPDB 77 1e-14 2XNP-A nrPDB 77 1e-14 4RC3-A nrPDB 77 2e-14 4GS6-A nrPDB 77 2e-14 2A1A-B nrPDB 77 2e-14 4OLI-A nrPDB 77 2e-14 4AGU-A nrPDB 77 2e-14 4QNY-A nrPDB 77 3e-14 3RAW-A nrPDB 77 3e-14 4E93-A nrPDB 77 3e-14 3BGP-A nrPDB 77 3e-14 4E7W-A nrPDB 76 3e-14 2H34-A nrPDB 76 3e-14 6DBM-A nrPDB 76 3e-14 5D7A-A nrPDB 76 4e-14 4G3E-A nrPDB 76 4e-14 1ZXE-A nrPDB 76 4e-14 3LLT-A nrPDB 76 5e-14 5B2L-A nrPDB 76 5e-14 6GVJ-A nrPDB 75 6e-14 4NEU-A nrPDB 75 7e-14 6E2O-A nrPDB 75 7e-14 3UIU-A nrPDB 75 7e-14 6FYV-A nrPDB 75 7e-14 2BUJ-A nrPDB 75 7e-14 6EII-A nrPDB 75 8e-14 4CSV-A nrPDB 75 1e-13 4UYA-A nrPDB 75 1e-13 2DQ7-X nrPDB 75 1e-13 4O2Z-A nrPDB 74 1e-13 3ORP-A nrPDB 74 1e-13 6FER-A nrPDB 74 1e-13 4MD7-E nrPDB 74 1e-13 3HMP-A nrPDB 74 2e-13 4XLV-A nrPDB 73 3e-13 2WTK-C nrPDB 73 3e-13 5AP3-A nrPDB 73 3e-13 2WO6-A nrPDB 73 3e-13 5WNO-A nrPDB 73 4e-13 3UIM-A nrPDB 73 4e-13 4X7Q-B nrPDB 72 5e-13 5UNP-A nrPDB 72 6e-13 5AMN-A nrPDB 72 6e-13 4IC8-A nrPDB 72 8e-13 5LPZ-A nrPDB 71 1e-12 2RIO-A nrPDB 71 1e-12 2QKW-B nrPDB 71 1e-12 4ZSG-A nrPDB 71 1e-12 4YFF-A nrPDB 71 1e-12 5LPV-A nrPDB 71 1e-12 6CQF-A nrPDB 71 1e-12 4C59-A nrPDB 71 2e-12 4U41-A nrPDB 70 2e-12 2ZMD-A nrPDB 70 2e-12 5X8I-B nrPDB 70 2e-12 4QTB-A nrPDB 70 2e-12 4E20-A nrPDB 70 2e-12 3DKO-A nrPDB 70 2e-12 2VWV-A nrPDB 70 2e-12 6F3F-A nrPDB 70 3e-12 6HMD-A nrPDB 70 3e-12 2W96-B nrPDB 70 3e-12 3HKO-A nrPDB 70 3e-12 5SYS-A nrPDB 70 4e-12 5UIU-A nrPDB 69 4e-12 2H8H-A nrPDB 69 4e-12 6FEX-A nrPDB 69 4e-12 2W1I-A nrPDB 69 5e-12 5TE0-A nrPDB 69 5e-12 1JPA-A nrPDB 69 5e-12 2PL0-A nrPDB 69 5e-12 6O6Q-A nrPDB 69 6e-12 5NGU-A nrPDB 69 6e-12 4UY9-A nrPDB 69 7e-12 4PWN-A nrPDB 69 8e-12 4IAN-A nrPDB 68 9e-12 2R2P-A nrPDB 68 9e-12 1K9A-A nrPDB 68 9e-12 5HLW-A nrPDB 68 1e-11 3IO7-A nrPDB 68 1e-11 4AU8-A nrPDB 68 1e-11 6HV0-A nrPDB 68 1e-11 1BYG-A nrPDB 68 1e-11 3I81-A nrPDB 68 1e-11 3QUP-A nrPDB 67 2e-11 5HVK-A nrPDB 67 2e-11 4M7I-A nrPDB 67 3e-11 4K33-A nrPDB 67 3e-11 3QD2-B nrPDB 67 3e-11 5EG3-A nrPDB 67 3e-11 2HK5-A nrPDB 67 3e-11 5XVU-A nrPDB 67 3e-11 3MIA-A nrPDB 66 3e-11 1U59-A nrPDB 66 4e-11 2XYN-A nrPDB 66 4e-11 2OZO-A nrPDB 66 4e-11 4EBW-A nrPDB 66 5e-11 5FM2-A nrPDB 66 5e-11 3CJF-A nrPDB 66 5e-11 3C1X-A nrPDB 65 5e-11 3DTC-A nrPDB 65 6e-11 4TPT-A nrPDB 65 8e-11 4PL5-B nrPDB 65 1e-10 1FVR-A nrPDB 65 1e-10 4P5Q-A nrPDB 65 1e-10 2PSQ-A nrPDB 65 1e-10 6BSD-A nrPDB 65 1e-10 4OW8-A nrPDB 65 1e-10 3TT0-A nrPDB 64 1e-10 1AD5-A nrPDB 64 1e-10 3E3P-A nrPDB 64 1e-10 4JLC-A nrPDB 64 1e-10 3PPZ-A nrPDB 64 1e-10 6NPU-A nrPDB 64 1e-10 3OZ6-A nrPDB 64 1e-10 2Y6O-A nrPDB 64 2e-10 5U6B-A nrPDB 64 2e-10 5H2U-A nrPDB 64 2e-10 3A4O-X nrPDB 64 2e-10 4Y83-A nrPDB 64 2e-10 3DLS-A nrPDB 64 2e-10 5A46-A nrPDB 64 2e-10 4X3F-A nrPDB 64 2e-10 2J0K-A nrPDB 64 2e-10 3GQL-A nrPDB 64 2e-10 3QGY-A nrPDB 64 2e-10 6B2Q-A nrPDB 64 2e-10 4XEY-B nrPDB 63 3e-10 3PP0-A nrPDB 63 3e-10 5X5O-A nrPDB 63 3e-10 5WNL-A nrPDB 63 4e-10 6DBN-A nrPDB 62 5e-10 4Y93-A nrPDB 62 5e-10 5IKW-A nrPDB 62 6e-10 2FO0-A nrPDB 62 7e-10 3KUL-B nrPDB 62 8e-10 4EUU-A nrPDB 62 8e-10 6NT9-A nrPDB 62 8e-10 2PVN-A nrPDB 62 9e-10 5MJB-A nrPDB 62 1e-09 4EUT-A nrPDB 62 1e-09 3GC0-A nrPDB 61 1e-09 5L6P-A nrPDB 61 1e-09 1LUF-A nrPDB 61 1e-09 6O8B-A nrPDB 61 2e-09 4H1J-A nrPDB 60 2e-09 5O0Y-A nrPDB 60 2e-09 5CEK-A nrPDB 60 2e-09 3PG1-A nrPDB 60 2e-09 3M42-A nrPDB 60 2e-09 6DC0-A nrPDB 60 2e-09 1U5R-A nrPDB 60 3e-09 2GCD-A nrPDB 60 3e-09 4M66-A nrPDB 60 3e-09 6BFN-A nrPDB 60 3e-09 4AT3-A nrPDB 60 4e-09 3ZBF-A nrPDB 60 4e-09 3KRL-A nrPDB 60 4e-09 3SXS-A nrPDB 59 4e-09 4CRL-A nrPDB 59 4e-09 3SOC-A nrPDB 59 4e-09 6E4F-A nrPDB 59 4e-09 3AOX-A nrPDB 59 4e-09 5U6C-A nrPDB 59 5e-09 2OGV-A nrPDB 59 5e-09 3RP9-A nrPDB 59 5e-09 6GQK-A nrPDB 59 6e-09 4XI2-A nrPDB 59 7e-09 3VHK-A nrPDB 59 8e-09 4PDO-A nrPDB 58 9e-09 3HNG-A nrPDB 58 1e-08 4LFI-A nrPDB 58 1e-08 5GNK-A nrPDB 58 1e-08 3BEA-A nrPDB 58 1e-08 3ZZW-A nrPDB 57 2e-08 5GRN-A nrPDB 57 2e-08 3PLS-A nrPDB 57 2e-08 4R7H-A nrPDB 57 2e-08 3LZB-A nrPDB 57 2e-08 4XCU-A nrPDB 57 2e-08 2I6L-A nrPDB 57 2e-08 3NIE-A nrPDB 57 2e-08 3G0E-A nrPDB 57 2e-08 3BBT-B nrPDB 57 2e-08 4F0G-A nrPDB 57 2e-08 4HZS-A nrPDB 56 5e-08 1U54-B nrPDB 55 6e-08 3V5Q-A nrPDB 55 6e-08 3N9X-A nrPDB 55 6e-08 2JD5-A nrPDB 55 6e-08 4XUF-A nrPDB 55 8e-08 5X02-A nrPDB 55 8e-08 5XD6-A nrPDB 55 9e-08 5AR8-A nrPDB 55 1e-07 3MY0-A nrPDB 55 1e-07 4FL3-A nrPDB 53 4e-07 4LRM-A nrPDB 53 5e-07 4RT7-A nrPDB 52 5e-07 3Q4U-A nrPDB 52 6e-07 5X18-A nrPDB 52 6e-07 1PY5-A nrPDB 52 6e-07 3LMG-A nrPDB 52 7e-07 6EQI-C nrPDB 52 7e-07 5C26-A nrPDB 52 8e-07 4Y12-A nrPDB 52 9e-07 5OAT-A nrPDB 52 1e-06 2PZI-A nrPDB 51 1e-06 2QLU-A nrPDB 50 2e-06 4I94-A nrPDB 50 3e-06 2CMW-A nrPDB 49 7e-06 5VDK-A nrPDB 49 7e-06 6J6I-B nrPDB 49 8e-06 5KMM-A nrPDB 49 8e-06 3EB0-A nrPDB 48 9e-06 2Y4I-B nrPDB 48 1e-05 5VC6-A nrPDB 48 1e-05 5J0A-A nrPDB 47 2e-05 2C47-A nrPDB 47 2e-05 4NFN-A nrPDB 47 2e-05 4BTK-A nrPDB 47 2e-05 3MDY-A nrPDB 47 3e-05 2CHL-A nrPDB 46 4e-05 5CLR-A nrPDB 45 7e-05 3G2F-A nrPDB 45 8e-05 5DMZ-A nrPDB 45 9e-05 5E8V-A nrPDB 44 1e-04 4TN6-A nrPDB 44 2e-04 1CSN-A nrPDB 44 2e-04 4F9B-A nrPDB 44 2e-04 4NT4-A nrPDB 44 2e-04 3SV0-A nrPDB 44 2e-04 6EWX-A nrPDB 44 3e-04 5M07-A nrPDB 43 4e-04 4JRN-A nrPDB 42 5e-04 4XHL-A nrPDB 42 6e-04 4L68-A nrPDB 42 6e-04 4XHH-A nrPDB 42 7e-04 3REP-A nrPDB 41 0.002 5FQD-C nrPDB 40 0.004 2X7G-A nrPDB 39 0.005 4WUA-A nrPDB 37 0.016 4M69-B nrPDB 37 0.020 6BHC-A nrPDB 37 0.023 4BTF-A nrPDB 37 0.025 4CYJ-A nrPDB 37 0.029 3BYV-A nrPDB 37 0.029 6M7Z-A nrPDB 36 0.052 5UU1-A nrPDB 35 0.079 5VE6-A nrPDB 35 0.086 3DZO-A nrPDB 34 0.18 4O1O-A nrPDB 34 0.19 3BL5-A nrPDB 32 1.1 4IX6-A nrPDB 31 1.2 5X1R-A nrPDB 31 1.4 4MWI-A nrPDB 31 1.6 2W1Z-A nrPDB 30 1.9 4AZV-A nrPDB 30 2.9 3EZ1-A nrPDB 30 3.0 2RSV-A nrPDB 30 3.2 2LAV-A nrPDB 30 3.9 4AZW-A nrPDB 29 4.7 4CI6-B nrPDB 29 4.9 4N8G-A nrPDB 29 6.7 >3NYO-A nrPDB Length = 576 Score = 1189 bits (3075), Expect = 0.0, Method: Compositional matrix adjust. Identities = 575/575 (100%), Positives = 575/575 (100%) Query: 2 ELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQP 61 ELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQP Sbjct: 2 ELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQP 61 Query: 62 IGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPEV 121 IGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPEV Sbjct: 62 IGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPEV 121 Query: 122 PRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPV 181 PRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPV Sbjct: 122 PRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPV 181 Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV Sbjct: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED Sbjct: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER 361 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER Sbjct: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER 361 Query: 362 YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCS 421 YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCS Sbjct: 362 YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCS 421 Query: 422 QLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIE 481 QLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIE Sbjct: 422 QLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIE 481 Query: 482 QFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWKG 541 QFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWKG Sbjct: 482 QFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWKG 541 Query: 542 QPPAPPKKGLLQRLFSRQDCCGNCSDSEEELPTRL 576 QPPAPPKKGLLQRLFSRQDCCGNCSDSEEELPTRL Sbjct: 542 QPPAPPKKGLLQRLFSRQDCCGNCSDSEEELPTRL 576 >4TNB-A nrPDB Length = 590 Score = 817 bits (2111), Expect = 0.0, Method: Compositional matrix adjust. Identities = 403/559 (72%), Positives = 470/559 (84%), Gaps = 1/559 (0%) Query: 1 MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ 60 MELENIVANTVLLKAREGGGG RKGKSKKW+++L+FPHISQCE+LR +++RDY SLC++Q Sbjct: 1 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ 60 Query: 61 PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE 120 PIGRLLFR+FC TRP L + FLD VAEYEVTPD+K G+++ +L+ P I + Sbjct: 61 PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKKIMTKYLTPKSPVFIAQ 120 Query: 121 VPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQP 180 V + LV+ ++L Q PCK+LF + HEYL PF +YLDS++F+RFLQWKWLERQP Sbjct: 121 VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQP 180 Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACK+LEKKRIKKRKGE+MALNEKQILEK Sbjct: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 VNS+FVV+LAYAYETKDALCLVLT+MNGGDLKFHIY+MG GF E RA+FYAAEI CGLE Sbjct: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 Query: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE 360 DLH E VYRDLKPENILLDD+GHIRISDLGLAV +PEG I+GRVGTVGYMAPEV+ N+ Sbjct: 301 DLHHENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 Query: 361 RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC 420 RY SPD+W LGCL+YEMI GQSPF+ RK+K+KREEV+R V E E YS +FS +A+S+C Sbjct: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 Query: 421 SQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDI 480 LL KD +RLGC+ A EVK HP F+ +NFKRL AGML+PPF PDP+A+YCKDVLDI Sbjct: 421 KMLLTKDAKQRLGCQEEEAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI 480 Query: 481 EQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWK 540 EQFSTVKGV L+ TD DFY KF+TGSV IPWQNEM+ETECF+ELNVFG +G++PPDL+ + Sbjct: 481 EQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLN-R 539 Query: 541 GQPPAPPKKGLLQRLFSRQ 559 PP PPKKGLLQRLF RQ Sbjct: 540 NHPPEPPKKGLLQRLFKRQ 558 >4YHJ-A nrPDB Length = 584 Score = 761 bits (1964), Expect = 0.0, Method: Compositional matrix adjust. Identities = 374/560 (66%), Positives = 445/560 (79%), Gaps = 2/560 (0%) Query: 1 MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ 60 MELENIVAN++LLKAR+GG G + G+SKKW+++L P +SQC ELR S+E+DY SLC++Q Sbjct: 1 MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60 Query: 61 PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE 120 PIGR LFR+FC T+P L R + FLD VAEYEV D+ R CG + F + +PE Sbjct: 61 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120 Query: 121 VPRQLVTNCTQRL-EQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQ 179 +P +VT C L E+ P K F+E TR+ H YL PF +Y +S YF++FLQWKWLERQ Sbjct: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180 Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 PVTKNTFR YRVLGKGGFGEVCACQVRATGKMYACKKL+KKRIKKRKGEAMALNEK+ILE Sbjct: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 KV SRFVVSLAYAYETKDALCLVLT+MNGGDLKFHIY++G GF E RAVFYAAE+CCGL Sbjct: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359 EDL RERIVYRDLKPENILLDD GHIRISDLGLA +PEGQ ++GRVGTVGYMAPEVV N Sbjct: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360 Query: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419 E+YTFSPDWW LGCL+YEMI G SPF++ K+K+K EEV++ +K EEYSE+FS A+S+ Sbjct: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420 Query: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLD 479 C LL K+P++RLGCRG A VK+HP+FK +NF+RL A MLEPPF PDP A+YCKDVLD Sbjct: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 480 Query: 480 IEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDW 539 IEQFS VKG+ L+ D+DFY +FATG V IPWQNEM+E+ CF+++N + ++P DLD Sbjct: 481 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK 540 Query: 540 KGQPPAP-PKKGLLQRLFSR 558 P P +G RLF R Sbjct: 541 NIHTPVSRPNRGFFYRLFRR 560 >3C51-A nrPDB Length = 543 Score = 485 bits (1249), Expect = e-137, Method: Compositional matrix adjust. Identities = 255/534 (47%), Positives = 353/534 (66%), Gaps = 9/534 (1%) Query: 3 LENIVANTVLLKAREG--GGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ 60 LE +VAN+ + AR + +K+ L+ P +S+CE LR SL+ + +C Q Sbjct: 6 LETVVANSAFIAARGSFDASSGPASRDRKYLARLKLPPLSKCEALRESLDLGFEGMCLEQ 65 Query: 61 PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE 120 PIG+ LF++F T + + + +Y+ D R + L +L Sbjct: 66 PIGKRLFQQFLRTHEQHGPALQLWKDIEDYDTADDALRPQKAQALRAAYLEPQAQLFCSF 125 Query: 121 VPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQP 180 + + V R G LFQ L R +L APF ++LDS+YF RFLQWKWLE QP Sbjct: 126 LDAETVA----RARAGAGDGLFQPLLRAVLAHLGQAPFQEFLDSLYFLRFLQWKWLEAQP 181 Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 + ++ F +RVLG+GGFGEV ACQ++ATGK+YACKKL KKR+KKRKG A+ EK+IL K Sbjct: 182 MGEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAK 241 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQ--AGFPEARAVFYAAEICCG 298 V+SRF+VSLAYA+ETK LCLV+T+MNGGD+++HIY++ + GF E RA+FY A+I G Sbjct: 242 VHSRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSG 301 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT-IKGRVGTVGYMAPEVV 357 LE LH+ I+YRDLKPEN+LLDD G++RISDLGLAV + GQT KG GT G+MAPE++ Sbjct: 302 LEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELL 361 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 E Y FS D++ALG LYEMIA + PF+ R +K++ +E+++ V E Y ++FSP ++ Sbjct: 362 LGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASK 421 Query: 418 SLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDV 477 C LL KDP +RLG R GS ++ HPLF+ +++++L AGML PPF PD + +Y K++ Sbjct: 422 DFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDSRTVYAKNI 481 Query: 478 LDIEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDG 531 D+ FSTVKGV E D +F+Q+FA+G+ PIPWQ EM+ET F +LNV+ DG Sbjct: 482 QDVGAFSTVKGVAFEKADTEFFQEFASGTCPIPWQEEMIETGVFGDLNVWRPDG 535 >3PVW-A nrPDB Length = 695 Score = 321 bits (822), Expect = 6e-88, Method: Compositional matrix adjust. Identities = 212/546 (38%), Positives = 302/546 (55%), Gaps = 38/546 (6%) Query: 2 ELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCER-- 59 +LE ++A+ L A E ++ K + +L P I ++ LE E+ Sbjct: 3 DLEAVLADVSYLMAMEKSKATPAARASK-KILLPEPSIRSV--MQKYLEDRGEVTFEKIF 59 Query: 60 -QPIGRLLFREFCATRPELSR-CVAFLDGVAEYE-VTPDDKRKACGRQLTQNFL------ 110 Q +G LLFR+FC E ++ V F + + +YE + +++R C R++ ++ Sbjct: 60 SQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLA 119 Query: 111 -SHT-GPDLIPEVPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFN 168 SH I V LV +Q P DLFQ + L F +++S F Sbjct: 120 CSHPFSKSAIEHVQGHLVK------KQVP-PDLFQPYIEEICQNLRGDVFQKFIESDKFT 172 Query: 169 RFLQWKWLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKG 227 RF QWK +E +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK ++G Sbjct: 173 RFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQG 232 Query: 228 EAMALNEKQILEKVNSR---FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG-F 283 E +ALNE+ +L V++ F+V ++YA+ T D L +L LMNGGDL YH+ Q G F Sbjct: 233 ETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLH---YHLSQHGVF 289 Query: 284 PEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIK 343 EA FYAAEI GLE +H +VYRDLKP NILLD+HGH+RISDLGLA + + Sbjct: 290 SEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP-H 348 Query: 344 GRVGTVGYMAPEVV-KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVK 402 VGT GYMAPEV+ K Y S DW++LGC+L++++ G SPF+Q K K K E++R+ Sbjct: 349 ASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTL 407 Query: 403 EVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLE 462 + E + FSP+ RSL LL +D RLGC G A+EVKE P F+ L+++ + Sbjct: 408 TMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYP 467 Query: 463 PPFKPDPQAIYCKDVLDIEQFS--TVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETEC 520 PP P + D DI F KG++L +DQ+ Y+ F ++ WQ E+ ET Sbjct: 468 PPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET-V 525 Query: 521 FQELNV 526 F +N Sbjct: 526 FDTINA 531 >5UUU-A nrPDB Length = 547 Score = 318 bits (816), Expect = 3e-87, Method: Compositional matrix adjust. Identities = 197/482 (40%), Positives = 279/482 (57%), Gaps = 26/482 (5%) Query: 60 QPIGRLLFREFCATRPELSR-CVAFLDGVAEYE-VTPDDKRKACGRQLTQNFLSHTGPDL 117 Q +G LLFR+FC E +R V F + + +YE + +++R A R++ F S+ +L Sbjct: 70 QKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREI---FDSYIMKEL 126 Query: 118 IPEVPRQLVTNCTQRLEQGPCK-----DLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQ 172 + + T+ ++ K DLFQ + L F +++S F RF Q Sbjct: 127 LA-CSHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQ 185 Query: 173 WKWLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMA 231 WK +E +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK ++GE +A Sbjct: 186 WKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLA 245 Query: 232 LNEKQILEKVNSR---FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG-FPEAR 287 LNE+ +L V++ F+V ++YA+ T D L +L LMNGGDL YH+ Q G F EA Sbjct: 246 LNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLH---YHLSQHGVFSEAD 302 Query: 288 AVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVG 347 FYAAEI GLE +H +VYRDLKP NILLD+HGH+RISDLGLA + + VG Sbjct: 303 MRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP-HASVG 361 Query: 348 TVGYMAPEVV-KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPE 406 T GYMAPEV+ K Y S DW++LGC+L++++ G SPF+Q K K K E++R+ + Sbjct: 362 THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKH-EIDRMTLTMAV 420 Query: 407 EYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFK 466 E + FSP+ RSL LL +D RLGC G A+EVKE P F+ L+++ + PP Sbjct: 421 ELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLI 480 Query: 467 PDPQAIYCKDVLDIEQFS--TVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQEL 524 P + D DI F KG++L +DQ+ Y+ F ++ WQ E+ ET F + Sbjct: 481 PPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET-VFDTI 538 Query: 525 NV 526 N Sbjct: 539 NA 540 >2JDO-A nrPDB Length = 342 Score = 218 bits (554), Expect = 7e-57, Method: Compositional matrix adjust. Identities = 123/317 (38%), Positives = 182/317 (57%), Gaps = 9/317 (2%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 VT N F ++LGKG FG+V + +ATG+ YA K L K+ I + A + E ++L+ Sbjct: 7 VTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQN 66 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 F+ +L YA++T D LC V+ NGG+L FH+ + F E RA FY AEI LE Sbjct: 67 TRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSR--ERVFTEERARFYGAEIVSALE 124 Query: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVH-VPEGQTIKGRVGTVGYMAPEVVKN 359 LH +VYRD+K EN++LD GHI+I+D GL + +G T+K GT Y+APEV+++ Sbjct: 125 YLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLED 184 Query: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419 Y + DWW LG ++YEM+ G+ PF + + E + L++E+ + SP+A+SL Sbjct: 185 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELI--LMEEI--RFPRTLSPEAKSL 240 Query: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLD 479 + LL KDP +RLG A+EV EH F +N++ + L PPFK PQ D Sbjct: 241 LAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFK--PQVTSEVDTRY 298 Query: 480 IEQFSTVKGVELEPTDQ 496 + T + + + P D+ Sbjct: 299 FDDEFTAQSITITPPDR 315 >3MV5-A nrPDB Length = 342 Score = 216 bits (551), Expect = 2e-56, Method: Compositional matrix adjust. Identities = 123/319 (38%), Positives = 185/319 (57%), Gaps = 10/319 (3%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 VT N F ++LGKG FG+V + +ATG+ YA K L+K+ I + A L E ++L+ Sbjct: 7 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 66 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 F+ +L Y+++T D LC V+ NGG+L FH+ + F E RA FY AEI L+ Sbjct: 67 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALD 124 Query: 301 DLHRER-IVYRDLKPENILLDDHGHIRISDLGLAVH-VPEGQTIKGRVGTVGYMAPEVVK 358 LH E+ +VYRDLK EN++LD GHI+I+D GL + +G T+K GT Y+APEV++ Sbjct: 125 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 184 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARS 418 + Y + DWW LG ++YEM+ G+ PF + + E + L++E+ + P+A+S Sbjct: 185 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI--LMEEI--RFPRTLGPEAKS 240 Query: 419 LCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVL 478 L S LL KDP +RLG A+E+ +H F + ++ + L PPFK PQ D Sbjct: 241 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFK--PQVTSETDTR 298 Query: 479 DIEQFSTVKGVELEPTDQD 497 ++ T + + + P DQD Sbjct: 299 YFDEEFTAQMITITPPDQD 317 >4RA4-A nrPDB Length = 355 Score = 212 bits (539), Expect = 4e-55, Method: Compositional matrix adjust. Identities = 123/323 (38%), Positives = 187/323 (57%), Gaps = 13/323 (4%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEK 235 L+R +T F VLGKG FG+V + T ++YA K L+K + + + EK Sbjct: 14 LDRVKLTDFNFLM--VLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEK 71 Query: 236 QILEKVNSR-FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAE 294 ++L ++ F+ L ++T D L V+ +NGGDL +HI +G+ F E +AVFYAAE Sbjct: 72 RVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGK--FKEPQAVFYAAE 129 Query: 295 ICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGL-AVHVPEGQTIKGRVGTVGYMA 353 I GL LH+ I+YRDLK +N++LD GHI+I+D G+ H+ +G T + GT Y+A Sbjct: 130 ISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIA 189 Query: 354 PEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFS 413 PE++ + Y S DWWA G LLYEM+AGQ PF + +E+ + + E Y + S Sbjct: 190 PEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDE----DELFQSIMEHNVSYPKSLS 245 Query: 414 PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIY 473 +A S+C L+ K PA+RLGC R+V+EH F+++++++L ++PPFKP + Sbjct: 246 KEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKP---KVS 302 Query: 474 CKDVLDIEQFSTVKGVELEPTDQ 496 K + ++F T L P DQ Sbjct: 303 GKGAENFDKFFTRGQPVLTPPDQ 325 >5KCV-A nrPDB Length = 460 Score = 211 bits (538), Expect = 6e-55, Method: Compositional matrix adjust. Identities = 116/292 (39%), Positives = 174/292 (59%), Gaps = 8/292 (2%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQI 237 + VT N F ++LGKG FG+V + +ATG+ YA K L+K+ I + A L E ++ Sbjct: 156 KHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRV 215 Query: 238 LEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 L+ F+ +L Y+++T D LC V+ NGG+L FH+ + F E RA FY AEI Sbjct: 216 LQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVS 273 Query: 298 GLEDLHRER-IVYRDLKPENILLDDHGHIRISDLGLAVH-VPEGQTIKGRVGTVGYMAPE 355 L+ LH E+ +VYRDLK EN++LD GHI+I+D GL + +G T+K GT Y+APE Sbjct: 274 ALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPE 333 Query: 356 VVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQ 415 V+++ Y + DWW LG ++YEM+ G+ PF + + E + L++E+ + P+ Sbjct: 334 VLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI--LMEEI--RFPRTLGPE 389 Query: 416 ARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKP 467 A+SL S LL KDP +RLG A+E+ +H F + ++ + L PPFKP Sbjct: 390 AKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 441 >3PFQ-A nrPDB Length = 674 Score = 202 bits (515), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 115/314 (36%), Positives = 180/314 (57%), Gaps = 11/314 (3%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR- 244 F VLGKG FG+V + + T ++YA K L+K + + + EK++L Sbjct: 343 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 402 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 F+ L ++T D L V+ +NGGDL +HI +G+ F E AVFYAAEI GL L Sbjct: 403 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGLFFLQS 460 Query: 305 ERIVYRDLKPENILLDDHGHIRISDLGLAV-HVPEGQTIKGRVGTVGYMAPEVVKNERYT 363 + I+YRDLK +N++LD GHI+I+D G+ ++ +G T K GT Y+APE++ + Y Sbjct: 461 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYG 520 Query: 364 FSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQL 423 S DWWA G LLYEM+AGQ+PF+ + +E+ + + E Y + S +A ++C L Sbjct: 521 KSVDWWAFGVLLYEMLAGQAPFEGEDE----DELFQSIMEHNVAYPKSMSKEAVAICKGL 576 Query: 424 LCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQF 483 + K P +RLGC R++KEH F+ +++++L ++PP+KP ++ + ++F Sbjct: 577 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKASG---RNAENFDRF 633 Query: 484 STVKGVELEPTDQD 497 T L P DQ+ Sbjct: 634 FTRHPPVLTPPDQE 647 >2I0E-A nrPDB Length = 353 Score = 201 bits (512), Expect = 5e-52, Method: Compositional matrix adjust. Identities = 115/314 (36%), Positives = 180/314 (57%), Gaps = 11/314 (3%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR- 244 F VLGKG FG+V + + T ++YA K L+K + + + EK++L Sbjct: 22 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 81 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 F+ L ++T D L V+ +NGGDL +HI +G+ F E AVFYAAEI GL L Sbjct: 82 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGLFFLQS 139 Query: 305 ERIVYRDLKPENILLDDHGHIRISDLGLAV-HVPEGQTIKGRVGTVGYMAPEVVKNERYT 363 + I+YRDLK +N++LD GHI+I+D G+ ++ +G T K GT Y+APE++ + Y Sbjct: 140 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYG 199 Query: 364 FSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQL 423 S DWWA G LLYEM+AGQ+PF+ + +E+ + + E Y + S +A ++C L Sbjct: 200 KSVDWWAFGVLLYEMLAGQAPFEGEDE----DELFQSIMEHNVAYPKSMSKEAVAICKGL 255 Query: 424 LCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQF 483 + K P +RLGC R++KEH F+ +++++L ++PP+KP ++ + ++F Sbjct: 256 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACG---RNAENFDRF 312 Query: 484 STVKGVELEPTDQD 497 T L P DQ+ Sbjct: 313 FTRHPPVLTPPDQE 326 >4L42-A nrPDB Length = 346 Score = 199 bits (505), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 116/295 (39%), Positives = 172/295 (58%), Gaps = 19/295 (6%) Query: 186 FRQYRVLGKGGFGEVCACQVRA-----TGKMYACKKLEKKRI-KKRKGEAMALNEKQILE 239 F RVLGKGG+G+V QVR TGK++A K L+K I + K A E+ ILE Sbjct: 20 FELLRVLGKGGYGKVF--QVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE 77 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 +V F+V L YA++T L L+L ++GG+L + G F E A FY AEI L Sbjct: 78 EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGI--FMEDTACFYLAEISMAL 135 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGL---AVHVPEGQTIKGRVGTVGYMAPEV 356 LH++ I+YRDLKPENI+L+ GH++++D GL ++H +G GT+ YMAPE+ Sbjct: 136 GHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIH--DGTVTHTFCGTIEYMAPEI 193 Query: 357 VKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQA 416 + + + DWW+LG L+Y+M+ G PF +K +++ + +P ++ +A Sbjct: 194 LMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQ----EA 249 Query: 417 RSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQA 471 R L +LL ++ A RLG G A EV+ HP F+ +N++ L A +EPPFKP Q+ Sbjct: 250 RDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQS 304 >1VZO-A nrPDB Length = 355 Score = 198 bits (504), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 117/314 (37%), Positives = 176/314 (56%), Gaps = 16/314 (5%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRA---TGKMYACKKLEKKRI-KKRKGEAMALNE 234 + V F +VLG G +G+V + + TGK+YA K L+K I +K K E Sbjct: 49 EKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTE 108 Query: 235 KQILEKV-NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAA 293 +Q+LE + S F+V+L YA++T+ L L+L +NGG+L H+ + F E Y Sbjct: 109 RQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQ--RERFTEHEVQIYVG 166 Query: 294 EICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR--VGTVGY 351 EI LE LH+ I+YRD+K ENILLD +GH+ ++D GL+ +T + GT+ Y Sbjct: 167 EIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEY 226 Query: 352 MAPEVVK--NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYS 409 MAP++V+ + + + DWW+LG L+YE++ G SPF +K + E+ R + + Y Sbjct: 227 MAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYP 286 Query: 410 ERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDP 469 + S A+ L +LL KDP +RLGC A E+KEH F+K+N+ L A + PFKP Sbjct: 287 QEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKP-- 344 Query: 470 QAIYCKDVLDIEQF 483 +D LD+ F Sbjct: 345 ---VIRDELDVSNF 355 >3A8W-A nrPDB Length = 345 Score = 198 bits (504), Expect = 5e-51, Method: Compositional matrix adjust. Identities = 114/330 (34%), Positives = 178/330 (53%), Gaps = 12/330 (3%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 P+ F RV+G+G + +V +++ T ++YA K ++K+ + + EK + E Sbjct: 5 PLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFE 64 Query: 240 KV-NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 + N F+V L ++T+ L V+ +NGGDL FH+ Q PE A FY+AEI Sbjct: 65 QASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQR--QRKLPEEHARFYSAEISLA 122 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVH-VPEGQTIKGRVGTVGYMAPEVV 357 L LH I+YRDLK +N+LLD GHI+++D G+ + G T GT Y+APE++ Sbjct: 123 LNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEIL 182 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSPF-----QQRKKKIKREEVERLVKEVPEEYSERF 412 + E Y FS DWWALG L++EM+AG+SPF + + + +++ E Sbjct: 183 RGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSL 242 Query: 413 SPQARSLCSQLLCKDPAERLGCRGGSA-REVKEHPLFKKLNFKRLGAGMLEPPFKPDPQA 471 S +A S+ L KDP ERLGC + +++ HP F+ +++ + + PPFKP+ Sbjct: 243 SVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISG 302 Query: 472 IYCKDVLDIEQFSTVKGVELEPTDQDFYQK 501 + D D QF T + V+L P D D +K Sbjct: 303 EFGLDNFD-SQF-TNEPVQLTPDDDDIVRK 330 >4RLP-A nrPDB Length = 288 Score = 197 bits (500), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 115/291 (39%), Positives = 170/291 (58%), Gaps = 19/291 (6%) Query: 186 FRQYRVLGKGGFGEVCACQVRA-----TGKMYACKKLEKKRI-KKRKGEAMALNEKQILE 239 F RVLGKGG+G+V QVR TGK++A K L+K I + K A E+ ILE Sbjct: 7 FELLRVLGKGGYGKVF--QVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE 64 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 +V F+V L YA++T L L+L ++GG+L + G F E A FY AEI L Sbjct: 65 EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGI--FMEDTACFYLAEISMAL 122 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGL---AVHVPEGQTIKGRVGTVGYMAPEV 356 LH++ I+YRDLKPENI+L+ GH++++D GL ++H +G GT+ YMAPE+ Sbjct: 123 GHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIH--DGTVTHTFCGTIEYMAPEI 180 Query: 357 VKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQA 416 + + + DWW+LG L+Y+M+ G PF +K +++ + +P ++ +A Sbjct: 181 LMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQ----EA 236 Query: 417 RSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKP 467 R L +LL ++ A RLG G A EV+ HP F+ +N++ L A +EPPFKP Sbjct: 237 RDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP 287 >5F9E-A nrPDB Length = 353 Score = 192 bits (488), Expect = 4e-49, Method: Compositional matrix adjust. Identities = 110/326 (33%), Positives = 178/326 (54%), Gaps = 18/326 (5%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR- 244 F +++LGKG FG+V + + T + +A K L+K + + EK++L Sbjct: 21 FELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHP 80 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 F+ + ++TK+ L V+ +NGGDL +HI + F +RA FYAAEI GL+ LH Sbjct: 81 FLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHK--FDLSRATFYAAEIILGLQFLHS 138 Query: 305 ERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRV-GTVGYMAPEVVKNERYT 363 + IVYRDLK +NILLD GHI+I+D G+ G GT Y+APE++ ++Y Sbjct: 139 KGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLGQKYN 198 Query: 364 FSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQL 423 S DWW+ G LLYEM+ GQSPF + + EE+ ++ Y +A+ L +L Sbjct: 199 HSVDWWSFGVLLYEMLIGQSPFHGQDE----EELFHSIRMDNPFYPRWLEKEAKDLLVKL 254 Query: 424 LCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIE-- 481 ++P +RLG RG ++++HPLF+++N++ L ++PPF+P ++ + D E Sbjct: 255 FVREPEKRLGVRG----DIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSNFDKEFL 310 Query: 482 ----QFSTVKGVELEPTDQDFYQKFA 503 + S + DQ+ ++ F+ Sbjct: 311 NEKPRLSFADRALINSMDQNMFRNFS 336 >3HDN-A nrPDB Length = 373 Score = 190 bits (483), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 113/285 (39%), Positives = 155/285 (54%), Gaps = 9/285 (3%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK-VNSR 244 F +V+GKG FG+V + +A YA K L+KK I K+K E ++E+ +L K V Sbjct: 40 FHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP 99 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 F+V L ++++T D L VL +NGG+L +H+ + F E RA FYAAEI L LH Sbjct: 100 FLVGLHFSFQTADKLYFVLDYINGGELFYHL--QRERCFLEPRARFYAAEIASALGYLHS 157 Query: 305 ERIVYRDLKPENILLDDHGHIRISDLGL-AVHVPEGQTIKGRVGTVGYMAPEVVKNERYT 363 IVYRDLKPENILLD GHI ++D GL ++ T GT Y+APEV+ + Y Sbjct: 158 LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYD 217 Query: 364 FSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQL 423 + DWW LG +LYEM+ G PF R E+ + P + + AR L L Sbjct: 218 RTVDWWCLGAVLYEMLYGLPPFYSRNTA----EMYDNILNKPLQLKPNITNSARHLLEGL 273 Query: 424 LCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPD 468 L KD +RLG + E+K H F +N+ L + PPF P+ Sbjct: 274 LQKDRTKRLGAK-DDFMEIKSHVFFSLINWDDLINKKITPPFNPN 317 >2Z7Q-A nrPDB Length = 321 Score = 190 bits (483), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 109/286 (38%), Positives = 160/286 (55%), Gaps = 11/286 (3%) Query: 186 FRQYRVLGKGGFGEVCACQVRA---TGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 F +VLG+G FG+V + +G +YA K L+K +K R + E+ IL VN Sbjct: 30 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKM-ERDILADVN 88 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 FVV L YA++T+ L L+L + GGDL + + F E FY AE+ GL+ L Sbjct: 89 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRL--SKEVMFTEEDVKFYLAELALGLDHL 146 Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAVH-VPEGQTIKGRVGTVGYMAPEVVKNER 361 H I+YRDLKPENILLD+ GHI+++D GL+ + + GTV YMAPEVV + Sbjct: 147 HSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQG 206 Query: 362 YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCS 421 ++ S DWW+ G L++EM+ G PFQ + R+E L+ + + S +A+SL Sbjct: 207 HSHSADWWSYGVLMFEMLTGSLPFQGK----DRKETMTLILKAKLGMPQFLSTEAQSLLR 262 Query: 422 QLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKP 467 L ++PA RLG A E+K H + +++ +L ++PPFKP Sbjct: 263 ALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKP 308 >1FOT-A nrPDB Length = 318 Score = 190 bits (482), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 103/285 (36%), Positives = 159/285 (55%), Gaps = 8/285 (2%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 F+ R LG G FG V + R G+ YA K L+K+ + + K +E+ +L V F Sbjct: 8 FQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPF 67 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 ++ + ++ + +++ + GG+L F + Q FP A FYAAE+C LE LH + Sbjct: 68 IIRMWGTFQDAQQIFMIMDYIEGGEL-FSLLRKSQR-FPNPVAKFYAAEVCLALEYLHSK 125 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFS 365 I+YRDLKPENILLD +GHI+I+D G A +VP+ GT Y+APEVV + Y S Sbjct: 126 DIIYRDLKPENILLDKNGHIKITDFGFAKYVPD--VTYTLCGTPDYIAPEVVSTKPYNKS 183 Query: 366 PDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLC 425 DWW+ G L+YEM+AG +PF E++ P ++E + L S+L+ Sbjct: 184 IDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNE----DVKDLLSRLIT 239 Query: 426 KDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQ 470 +D ++RLG +VK HP FK++ +++L + +E P++P Q Sbjct: 240 RDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPPIQ 284 >5D9K-A nrPDB Length = 330 Score = 188 bits (478), Expect = 4e-48, Method: Compositional matrix adjust. Identities = 108/287 (37%), Positives = 160/287 (55%), Gaps = 13/287 (4%) Query: 186 FRQYRVLGKGGFGEVCACQVRATG----KMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 F +VLG+G FG+V + + +G ++YA K L+K +K R + E+ IL +V Sbjct: 32 FELLKVLGQGSFGKVFLVK-KISGSDARQLYAMKVLKKATLKVRDRVRTKM-ERDILVEV 89 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 N F+V L YA++T+ L L+L + GGDL + + F E FY AE+ L+ Sbjct: 90 NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK--EVMFTEEDVKFYLAELALALDH 147 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVH-VPEGQTIKGRVGTVGYMAPEVVKNE 360 LH I+YRDLKPENILLD+ GHI+++D GL+ + + GTV YMAPEVV Sbjct: 148 LHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRR 207 Query: 361 RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC 420 +T S DWW+ G L++EM+ G PFQ + +K E ++ + + SP+A+SL Sbjct: 208 GHTQSADWWSFGVLMFEMLTGTLPFQGKDRK----ETMTMILKAKLGMPQFLSPEAQSLL 263 Query: 421 SQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKP 467 L ++PA RLG E+K H F +++ +L + PPFKP Sbjct: 264 RMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKP 310 >3TXO-A nrPDB Length = 353 Score = 187 bits (476), Expect = 9e-48, Method: Compositional matrix adjust. Identities = 110/287 (38%), Positives = 156/287 (54%), Gaps = 9/287 (3%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV-N 242 + F RVLGKG FG+V +V+ TG +YA K L+K I + + EK+IL N Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 82 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 F+ L ++T D L V+ +NGGDL FHI + F EARA FYAAEI L L Sbjct: 83 HPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRR--FDEARARFYAAEIISALMFL 140 Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAVH-VPEGQTIKGRVGTVGYMAPEVVKNER 361 H + I+YRDLK +N+LLD GH +++D G+ + G T GT Y+APE+++ Sbjct: 141 HDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEML 200 Query: 362 YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCS 421 Y + DWWA+G LLYEM+ G +PF+ + E + L EV Y A + Sbjct: 201 YGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAI--LNDEVV--YPTWLHEDATGILK 256 Query: 422 QLLCKDPAERLGC-RGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKP 467 + K+P RLG G + HP FK++++ +L +EPPF+P Sbjct: 257 SFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRP 303 >4FR4-A nrPDB Length = 384 Score = 181 bits (460), Expect = 5e-46, Method: Compositional matrix adjust. Identities = 97/309 (31%), Positives = 161/309 (52%), Gaps = 10/309 (3%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 E + V + F R +GKG FG+VC Q T KMYA K + K++ +R E Q Sbjct: 8 ENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQ 67 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 I++ + F+V+L Y+++ ++ + +V+ L+ GGDL++H+ F E + E+ Sbjct: 68 IMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQ--NVHFKEETVKLFICELV 125 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 L+ L +RI++RD+KP+NILLD+HGH+ I+D +A +P I GT YMAPE+ Sbjct: 126 MALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEM 185 Query: 357 VKNER---YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFS 413 + + Y+F+ DWW+LG YE++ G+ P+ R +E V V Y +S Sbjct: 186 FSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVV-TYPSAWS 244 Query: 414 PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIY 473 + SL +LL +P +R +V+ P +N+ + L P F P+ + Sbjct: 245 QEMVSLLKKLLEPNPDQRF----SQLSDVQNFPYMNDINWDAVFQKRLIPGFIPNKGRLN 300 Query: 474 CKDVLDIEQ 482 C ++E+ Sbjct: 301 CDPTFELEE 309 >5X3F-B nrPDB Length = 393 Score = 176 bits (447), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 101/301 (33%), Positives = 160/301 (53%), Gaps = 18/301 (5%) Query: 172 QWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMA 231 +W+ + + F + + LG G FG V + + +G YA K L+K+++ K K Sbjct: 72 KWETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHT 131 Query: 232 LNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFY 291 LNEK+IL+ VN F+V L ++++ L +V+ + GG++ H+ +G+ P AR FY Sbjct: 132 LNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHAR--FY 189 Query: 292 AAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRV----G 347 AA+I E LH ++YRDLKPEN+L+D G+I+++D G A + +KGR G Sbjct: 190 AAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFA------KRVKGRTWTLCG 243 Query: 348 TVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSP-FQQRKKKIKREEVERLVKEVPE 406 T Y+APE++ ++ Y + DWWALG L+YEM AG P F + +I + V V+ Sbjct: 244 TPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVR---- 299 Query: 407 EYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFK 466 + FS + L LL D +R G ++K H F ++ + +E PF Sbjct: 300 -FPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFI 358 Query: 467 P 467 P Sbjct: 359 P 359 >5N23-A nrPDB Length = 352 Score = 176 bits (445), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 103/297 (34%), Positives = 158/297 (53%), Gaps = 9/297 (3%) Query: 172 QWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMA 231 +W+ + + F + R LG G FG V + + TG YA K L+K+++ K K Sbjct: 30 KWESPAQNTAHLDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHT 89 Query: 232 LNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFY 291 LNEK+I + VN F+V L ++++ L +VL GG++ H+ +G+ P AR FY Sbjct: 90 LNEKRIQQAVNFPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHAR--FY 147 Query: 292 AAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGY 351 AA+I E LH ++YRDLKPEN+L+D G+I+++D G A V +G+T GT Y Sbjct: 148 AAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRV-KGRTPWTLCGTPEY 206 Query: 352 MAPEVVKNERYTFSPDWWALGCLLYEMIAGQSP-FQQRKKKIKREEVERLVKEVPEEYSE 410 +APE++ ++ Y + DWWALG L+YEM AG P F + +I + V V+ + Sbjct: 207 LAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVR-----FPS 261 Query: 411 RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKP 467 FS + L LL D +R G ++K H F ++ + +E PF P Sbjct: 262 HFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIP 318 >4WB7-A nrPDB Length = 405 Score = 175 bits (444), Expect = 5e-44, Method: Compositional matrix adjust. Identities = 102/301 (33%), Positives = 160/301 (53%), Gaps = 18/301 (5%) Query: 172 QWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMA 231 +W+ + + F + + LG G FG V + + TG YA K L+K+++ K K Sbjct: 84 KWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHT 143 Query: 232 LNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFY 291 LNEK+IL+ VN F+V L ++++ L +V+ + GG++ H+ +G+ P AR FY Sbjct: 144 LNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHAR--FY 201 Query: 292 AAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRV----G 347 AA+I E LH ++YRDLKPEN+L+D G+I+++D G A + +KGR G Sbjct: 202 AAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFA------KRVKGRTWTLCG 255 Query: 348 TVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSP-FQQRKKKIKREEVERLVKEVPE 406 T Y+APE++ ++ Y + DWWALG L+YEM AG P F + +I + V V+ Sbjct: 256 TPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVR---- 311 Query: 407 EYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFK 466 + FS + L LL D +R G ++K H F ++ + +E PF Sbjct: 312 -FPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFI 370 Query: 467 P 467 P Sbjct: 371 P 371 >4OTD-A nrPDB Length = 341 Score = 171 bits (434), Expect = 6e-43, Method: Compositional matrix adjust. Identities = 112/296 (37%), Positives = 164/296 (55%), Gaps = 11/296 (3%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEK 235 L + P+T F+ VLG+G FG+V + R +G+++A K L+K I R + EK Sbjct: 4 LRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEK 63 Query: 236 QILEKVNSR---FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYA 292 +IL V S F+V+L ++T + +C V+ GGDL HI+ F E RA+FY+ Sbjct: 64 RILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIH---SDVFSEPRAIFYS 120 Query: 293 AEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVH-VPEGQTIKGRVGTVGY 351 A + GL+ LH +IVYRDLK +N+LLD G+++I+D GL + G GT + Sbjct: 121 ACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEF 180 Query: 352 MAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSER 411 +APEV+ + YT + DWW LG LLYEM+ G+SPF + EEV + Y Sbjct: 181 LAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDE----EEVFDSIVNDEVRYPRF 236 Query: 412 FSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKP 467 S +A + +LL ++P RLG A +VK+ P F+ L ++ L A L PPF P Sbjct: 237 LSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVP 292 >4CRS-A nrPDB Length = 341 Score = 169 bits (427), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 111/286 (38%), Positives = 159/286 (55%), Gaps = 11/286 (3%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR- 244 FR VL +G FG+V + + T +M+A K L+K I R + EK+I E VNS Sbjct: 14 FRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVR 73 Query: 245 --FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 F+V+L ++TK+ +C V+ GGDL HI+ F E RAVFYAA + GL+ L Sbjct: 74 HPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIH---TDVFSEPRAVFYAACVVLGLQYL 130 Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAVH-VPEGQTIKGRVGTVGYMAPEVVKNER 361 H +IVYRDLK +N+LLD G ++I+D GL + G GT ++APEV+ Sbjct: 131 HEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETS 190 Query: 362 YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCS 421 YT + DWW LG L+YEM+ G+SPF + EEV + Y S +A S+ Sbjct: 191 YTRAVDWWGLGVLIYEMLVGESPFPGDDE----EEVFDSIVNDEVRYPRFLSTEAISIMR 246 Query: 422 QLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKP 467 +LL ++P RLG A +VK+HP F+ +++ L ++PPF P Sbjct: 247 RLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIP 292 >3ORZ-A nrPDB Length = 316 Score = 162 bits (411), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 95/275 (34%), Positives = 152/275 (55%), Gaps = 10/275 (3%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 F+ ++LG+G F V + AT + YA K LEK+ I K E+ ++ +++ F Sbjct: 39 FKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPF 98 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 V L + ++ + L L+ G+L +I +G F E FY AEI LE LH + Sbjct: 99 FVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGS--FDETCTRFYTAEIVSALEYLHGK 156 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLA-VHVPEGQTIKGR--VGTVGYMAPEVVKNERY 362 I++RDLKPENILL++ HI+I+D G A V PE + + VGT Y++PE++ + Sbjct: 157 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSA 216 Query: 363 TFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQ 422 S D WALGC++Y+++AG PF+ + + +++ +L + P E+F P+AR L + Sbjct: 217 CKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFP----EKFFPKARDLVEK 272 Query: 423 LLCKDPAERLGCRGGSAR-EVKEHPLFKKLNFKRL 456 LL D +RLGC +K HP F+ + ++ L Sbjct: 273 LLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENL 307 >3TKU-A nrPDB Length = 433 Score = 157 bits (396), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 102/345 (29%), Positives = 180/345 (52%), Gaps = 28/345 (8%) Query: 166 YFNRFLQW-----KWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKK 220 Y FL+W + ++ + + F +V+G+G FGEV +++ T ++YA K L K Sbjct: 67 YVAEFLEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKW 126 Query: 221 RIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQ 280 + KR A E+ +L + +++ +L YA++ ++ L LV+ GGDL + + Sbjct: 127 EMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDL-LTLLSKFE 185 Query: 281 AGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQ 340 PE A FY E+ ++ +H+ V+RD+KP+N+LLD +GHIR++D G + + + Sbjct: 186 DKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDG 245 Query: 341 TIKGR--VGTVGYMAPEVVKNE-----RYTFSPDWWALGCLLYEMIAGQSPFQ-----QR 388 T++ VGT Y++PE+++ +Y DWW+LG +YEM+ G++PF + Sbjct: 246 TVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVET 305 Query: 389 KKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 KI E ER + P ++ S +A+ L +L+C RLG G + K+H F Sbjct: 306 YGKIMNHE-ERF--QFPSHVTD-VSEEAKDLIQRLICS-RERRLGQNG--IEDFKKHAFF 358 Query: 449 KKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEP 493 + LN++ + LE P+ PD + D++ ++ E+ P Sbjct: 359 EGLNWENIRN--LEAPYIPDVSSPSDTSNFDVDD-DVLRNTEILP 400 >5FET-A nrPDB Length = 847 Score = 156 bits (395), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 105/314 (33%), Positives = 160/314 (50%), Gaps = 18/314 (5%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 R++G+G FG V + T YA K + K+ I + E++I + + F++ L Sbjct: 539 RIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAENDHPFIIRL 598 Query: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 ++ + + L+ GG+L I +G P+A+ FY I +E LH IVY Sbjct: 599 VRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQ--FYLGSIILAIEYLHERNIVY 656 Query: 310 RDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR----VGTVGYMAPEVVKNERYTFS 365 RDLKPENILLD G++++ D G A + I+GR VGT YMAPEV+ + Y + Sbjct: 657 RDLKPENILLDKQGYVKLIDFGCA------KKIQGRAYTLVGTPHYMAPEVILGKGYGCT 710 Query: 366 PDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQ-ARSLCSQLL 424 D WALG LYE I G PF ++ + E+ R + + + S Q + +L +LL Sbjct: 711 VDIWALGVCLYEFICGPLPFGNDQE--DQLEIFRDILTGQLTFPDYVSDQDSINLMKRLL 768 Query: 425 CKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFS 484 C+ P R+GC +++KEH F N+ +L +LEPP + Y +D+ DI+Q Sbjct: 769 CRLPQGRIGCSINGFKDIKEHAFFGNFNWDKLAGRLLEPPLVSKGET-YAEDI-DIKQIE 826 Query: 485 TVKGV-ELEPTDQD 497 + E EP D D Sbjct: 827 EEDALNEGEPLDGD 840 >2VD5-A nrPDB Length = 412 Score = 156 bits (395), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 103/318 (32%), Positives = 161/318 (50%), Gaps = 21/318 (6%) Query: 166 YFNRFLQWK-----WLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKK 220 Y FLQW L+ + ++ F +V+G+G F EV +++ TG++YA K + K Sbjct: 38 YVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKW 97 Query: 221 RIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQ 280 + KR + E+ +L + R++ L +A++ ++ L LV+ GGDL + G+ Sbjct: 98 DMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGE 157 Query: 281 AGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQ 340 P A FY AEI ++ +HR V+RD+KP+NILLD GHIR++D G + + Sbjct: 158 R-IPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADG 216 Query: 341 TIKG--RVGTVGYMAPEVVKNERYTFSP-------DWWALGCLLYEMIAGQSPFQQRKKK 391 T++ VGT Y++PE+++ DWWALG YEM GQ+PF Sbjct: 217 TVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTA 276 Query: 392 IKREEVERLVKEVPEEYSERFSP-QARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 ++ + + + P +AR +LLC P RLG RGG A + + HP F Sbjct: 277 ETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCP-PETRLG-RGG-AGDFRTHPFFFG 333 Query: 451 LNFKRLGAGMLEPPFKPD 468 L++ L + PPF PD Sbjct: 334 LDWDGLRDSV--PPFTPD 349 >6ED6-A nrPDB Length = 415 Score = 155 bits (393), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 91/267 (34%), Positives = 140/267 (52%), Gaps = 12/267 (4%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 +V+G+G FGEV + +A+ K+YA K L K + KR A E+ I+ NS +VV L Sbjct: 94 KVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQL 153 Query: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 YA++ L +V+ M GGDL + M PE A FY AE+ L+ +H +++ Sbjct: 154 FYAFQDDRYLYMVMEYMPGGDL---VNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIH 210 Query: 310 RDLKPENILLDDHGHIRISDLGLAVHVPEGQTI--KGRVGTVGYMAPEVVKNER----YT 363 RD+KP+N+LLD HGH++++D G + + E + VGT Y++PEV+K++ Y Sbjct: 211 RDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYG 270 Query: 364 FSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQL 423 DWW++G LYEM+ G +PF ++ + S A++L Sbjct: 271 RECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAF 330 Query: 424 LCKDPAERLGCRGGSAREVKEHPLFKK 450 L D RLG G E+++HP FK Sbjct: 331 LT-DREVRLGRNG--VEEIRQHPFFKN 354 >6BDL-A nrPDB Length = 347 Score = 152 bits (383), Expect = 4e-37, Method: Compositional matrix adjust. Identities = 87/283 (30%), Positives = 148/283 (52%), Gaps = 5/283 (1%) Query: 186 FRQYRVLGKGGFGEVCACQVRAT-GKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 F LG GGFG V Q+++ K +A K L+K+ I + + +EKQI++ +S Sbjct: 36 FNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSD 95 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 F+V L ++ L +++ GG+L + G F ++ FY A + LH Sbjct: 96 FIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGS--FEDSTTRFYTACVVEAFAYLHS 153 Query: 305 ERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTF 364 + I+YRDLKPEN++LD G+ ++ D G A + G+ GT Y+APE++ N+ + Sbjct: 154 KGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDI 213 Query: 365 SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLL 424 S D+W+LG L+YE++ G PF + R + + E+ ++ + A +L +L Sbjct: 214 SADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMI--EFPKKIAKNAANLIKKLC 271 Query: 425 CKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKP 467 +P+ERLG +++++H F+ N++ L G L PP P Sbjct: 272 RDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIP 314 >5DYK-A nrPDB Length = 853 Score = 150 bits (378), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 95/299 (31%), Positives = 153/299 (51%), Gaps = 17/299 (5%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 R++G+G FG V + T YA K + K+ I + E++I + + F++ L Sbjct: 545 RIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAENDHPFIIRL 604 Query: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 ++ + L+ GG+L I +G +++A FY I +E LH IVY Sbjct: 605 VRTFKDSKYFYFLTELVTGGELYDAIRKLGL--LSKSQAQFYLGSIILAIEYLHERNIVY 662 Query: 310 RDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR----VGTVGYMAPEVVKNERYTFS 365 RDLKPENILLD G++++ D G A + ++GR VGT YMAPEV+ + Y + Sbjct: 663 RDLKPENILLDKQGYVKLIDFGCA------KKVQGRAYTLVGTPHYMAPEVILGKGYGCT 716 Query: 366 PDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFS-PQARSLCSQLL 424 D WALG LYE I G PF ++ + E+ R + + + + + +L +LL Sbjct: 717 VDIWALGICLYEFICGPLPFGNDEE--DQLEIFRDILTGQLTFPDYVTDTDSINLMKRLL 774 Query: 425 CKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQF 483 C+ P R+GC +++K+HP F N+ +L +L+PP + Y +D+ DI+Q Sbjct: 775 CRLPQGRIGCSINGFKDIKDHPFFSNFNWDKLAGRLLDPPLVSKSET-YAEDI-DIKQI 831 >4AW2-A nrPDB Length = 437 Score = 150 bits (378), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 94/298 (31%), Positives = 160/298 (53%), Gaps = 22/298 (7%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 + F +V+G+G FGEV +++ K++A K L K + KR A E+ +L + Sbjct: 73 REDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGD 132 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 S+++ +L YA++ + L LV+ GGDL + + PE A FY AE+ ++ + Sbjct: 133 SKWITTLHYAFQDDNNLYLVMDYYVGGDL-LTLLSKFEDRLPEEMARFYLAEMVIAIDSV 191 Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR--VGTVGYMAPEVVK-- 358 H+ V+RD+KP+NIL+D +GHIR++D G + + E T++ VGT Y++PE+++ Sbjct: 192 HQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAM 251 Query: 359 ---NERYTFSPDWWALGCLLYEMIAGQSPFQ-----QRKKKIKREEVERLVKEVPEEYSE 410 RY DWW+LG +YEM+ G++PF + KI + ER + P + ++ Sbjct: 252 EGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHK-ERF--QFPTQVTD 308 Query: 411 RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPD 468 S A+ L +L+C RLG G + K+HP F +++ + E P+ P+ Sbjct: 309 -VSENAKDLIRRLICS-REHRLGQNG--IEDFKKHPFFSGIDWDNIRN--CEAPYIPE 360 >6E9W-A nrPDB Length = 443 Score = 149 bits (377), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 89/267 (33%), Positives = 138/267 (51%), Gaps = 12/267 (4%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 +V+G+G FGEV + ++T K+YA K L K + KR A E+ I+ NS +VV L Sbjct: 108 KVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQL 167 Query: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 YA++ L +V+ M GGDL + M PE A FY AE+ L+ +H ++ Sbjct: 168 FYAFQDDRYLYMVMEYMPGGDL---VNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIH 224 Query: 310 RDLKPENILLDDHGHIRISDLGLAVHVPEGQTIK--GRVGTVGYMAPEVVKNE----RYT 363 RD+KP+N+LLD GH++++D G + + + ++ VGT Y++PEV+K++ Y Sbjct: 225 RDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYG 284 Query: 364 FSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQL 423 DWW++G LYEM+ G +PF ++ + S +A++L Sbjct: 285 RECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAF 344 Query: 424 LCKDPAERLGCRGGSAREVKEHPLFKK 450 L D RLG G E+K H FK Sbjct: 345 LT-DREVRLGRNG--VEEIKRHLFFKN 368 >5LOH-A nrPDB Length = 341 Score = 147 bits (372), Expect = 9e-36, Method: Compositional matrix adjust. Identities = 94/301 (31%), Positives = 156/301 (51%), Gaps = 25/301 (8%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 +P + F + + +G FG+V Q GK+YA K ++K + + E+ L Sbjct: 31 KPPSIEEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERDAL 88 Query: 239 EKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLK--FHIYHMGQAGFPEARAVFYAAEIC 296 S F+V L Y+ ++ + + LV+ + GGD+K HIY F E AV Y +E+ Sbjct: 89 ALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIY----GYFDEEMAVKYISEVA 144 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA-------VHVPEGQTIKGRVGTV 349 L+ LHR I++RDLKP+N+L+ + GHI+++D GL+ +++ + T + GT Sbjct: 145 LALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTP 204 Query: 350 GYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVP-EEY 408 Y+APE++ + + DWWALG L+E + G PF + + + L +++P E Sbjct: 205 DYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNI--LKRDIPWPEG 262 Query: 409 SERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPD 468 E+ S A+S LL D +R G +E+K HPLF ++++ L + PF P Sbjct: 263 EEKLSDNAQSAVEILLTIDDTKRAGM-----KELKRHPLFSDVDWENLQHQTM--PFIPQ 315 Query: 469 P 469 P Sbjct: 316 P 316 >4C0T-A nrPDB Length = 974 Score = 138 bits (347), Expect = 7e-33, Method: Compositional matrix adjust. Identities = 92/311 (29%), Positives = 156/311 (50%), Gaps = 24/311 (7%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 F+ + LG+G + V + TGK YA K L+K+ I K K EK L ++++R Sbjct: 268 FKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNRL 327 Query: 246 -VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 V+SL + ++ KD+L VL + G+L I E + A+I ++ +H Sbjct: 328 GVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLN--EECTRHFGAQILDAIKYMHD 385 Query: 305 ERIVYRDLKPENILLDDHGHIRISDLGLA----------VHVPEGQTIKGRVGTVGYMAP 354 +++RDLKPENILLDD I+I+D G A P K VGT Y++P Sbjct: 386 NGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVSP 445 Query: 355 EVVKNERYTFSP-DWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFS 413 E+++N +Y P D WA GC++Y+MIAG+ PF+ + + +++ +L +S F Sbjct: 446 ELLEN-KYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKL----QFAFSAGFP 500 Query: 414 PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIY 473 R L ++L P+ R + E+++H F+ ++FK + L P + P + Sbjct: 501 TIIRDLIKKILVLQPSRR-----ATIPEIQKHYFFQSVDFKDFDSIWLSDPPEIGPYKMT 555 Query: 474 CKDVLDIEQFS 484 K ++ + + + Sbjct: 556 AKSMMKVPELN 566 >2JC6-A nrPDB Length = 334 Score = 135 bits (339), Expect = 7e-32, Method: Compositional matrix adjust. Identities = 86/263 (32%), Positives = 133/263 (50%), Gaps = 7/263 (2%) Query: 175 WLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNE 234 W ++ K F LG G F EV + +ATGK++A K + KK +K + E+ NE Sbjct: 13 WKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGK--ESSIENE 70 Query: 235 KQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAE 294 +L K+ +V+L YE+ + L LV+ L++GG+L I G + E A + Sbjct: 71 IAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKG--FYTEKDASTLIRQ 128 Query: 295 ICCGLEDLHRERIVYRDLKPENILL---DDHGHIRISDLGLAVHVPEGQTIKGRVGTVGY 351 + + LHR IV+RDLKPEN+L D+ I ISD GL+ +G + GT GY Sbjct: 129 VLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGY 188 Query: 352 MAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSER 411 +APEV+ + Y+ + D W++G + Y ++ G PF E++ + E Y + Sbjct: 189 VAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDD 248 Query: 412 FSPQARSLCSQLLCKDPAERLGC 434 S A+ L+ KDP +R C Sbjct: 249 ISDSAKDFIRNLMEKDPNKRYTC 271 >6BXI-A nrPDB Length = 333 Score = 133 bits (335), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 92/340 (27%), Positives = 153/340 (45%), Gaps = 60/340 (17%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 F +V+G+G FGEV Q + TG +YA K L K + +++ E+ IL + +S + Sbjct: 8 FESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLW 67 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 VV + Y+++ K L L++ + GGD+ + M + E FY AE ++ +H+ Sbjct: 68 VVKMFYSFQDKLNLYLIMEFLPGGDMMTLL--MKKDTLTEEETQFYIAETVLAIDSIHQL 125 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEG-------------------------- 339 ++RD+KP+N+LLD GH+++SD GL + + Sbjct: 126 GFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKR 185 Query: 340 ----------QTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPF---- 385 Q VGT Y+APEV Y DWW+LG ++YEM+ G PF Sbjct: 186 KAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSET 245 Query: 386 --QQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVK 443 + KK + +E EVP S +A+ L + C + R+G G E+K Sbjct: 246 PQETYKKVMNWKETLTFPPEVP------ISEKAKDLILRFCC-EWEHRIGAPG--VEEIK 296 Query: 444 EHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQF 483 + F+ ++++ + +P +I K + D F Sbjct: 297 SNSFFEGVDWEHIRE-------RPAAISIEIKSIDDTSNF 329 >5JN2-A nrPDB Length = 525 Score = 131 bits (330), Expect = 8e-31, Method: Compositional matrix adjust. Identities = 84/271 (30%), Positives = 147/271 (54%), Gaps = 15/271 (5%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 + + ++ RVLGKG FGEV C+ + TG+ A K + K+++K++ + L E Q+L+ Sbjct: 63 AIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLK 122 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 +++ ++ L +E K LV + GG+L I + + F E A ++ G+ Sbjct: 123 QLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEI--ISRKRFSEVDAARIIRQVLSGI 180 Query: 300 EDLHRERIVYRDLKPENILLDD---HGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 +H+ +IV+RDLKPEN+LL+ +IRI D GL+ H + +K ++GT Y+APEV Sbjct: 181 TYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEV 240 Query: 357 VKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKK--IKREEVERLVKEVPEEYSERFSP 414 + Y D W+ G +LY +++G PF + +K+ E + E+P+ ++ S Sbjct: 241 LHG-TYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQ--WKKVSE 297 Query: 415 QARSLCSQLLCKDPAERLGCRGGSAREVKEH 445 A+ L ++L P+ R+ SAR+ +H Sbjct: 298 SAKDLIRKMLTYVPSMRI-----SARDALDH 323 >3MA6-A nrPDB Length = 298 Score = 131 bits (330), Expect = 8e-31, Method: Compositional matrix adjust. Identities = 84/271 (30%), Positives = 147/271 (54%), Gaps = 15/271 (5%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 + + ++ RVLGKG FGEV C+ + TG+ A K + K+++K++ + L E Q+L+ Sbjct: 28 AIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLK 87 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 +++ ++ L +E K LV + GG+L I + + F E A ++ G+ Sbjct: 88 QLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEI--ISRKRFSEVDAARIIRQVLSGI 145 Query: 300 EDLHRERIVYRDLKPENILLDDH---GHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 +H+ +IV+RDLKPEN+LL+ +IRI D GL+ H + +K ++GT Y+APEV Sbjct: 146 TYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEV 205 Query: 357 VKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKK--IKREEVERLVKEVPEEYSERFSP 414 + Y D W+ G +LY +++G PF + +K+ E + E+P+ ++ S Sbjct: 206 LHGT-YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQ--WKKVSE 262 Query: 415 QARSLCSQLLCKDPAERLGCRGGSAREVKEH 445 A+ L ++L P+ R+ SAR+ +H Sbjct: 263 SAKDLIRKMLTYVPSMRI-----SARDALDH 288 >4YZB-A nrPDB Length = 491 Score = 127 bits (319), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 86/269 (31%), Positives = 148/269 (55%), Gaps = 15/269 (5%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 ++ RVLGKG FGEV C+ + TG+ YA K + K+++K++ + + L E ++L+K++ Sbjct: 32 YKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHPN 91 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 ++ L +E K LV + GG+L I + + F E A ++ G+ +H+ Sbjct: 92 IMKLYEFFEDKGYFYLVTEVYTGGELFDEI--ISRKRFSEVDAARIIRQVLSGITYMHKN 149 Query: 306 RIVYRDLKPENILLDD---HGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERY 362 +IV+RDLKPEN+LL++ +IRI D GL+ H + +K ++GT Y+APEV+ Y Sbjct: 150 KIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHG-TY 208 Query: 363 TFSPDWWALGCLLYEMIAGQSPFQQRKK--KIKREEVERLVKEVPEEYSERFSPQARSLC 420 D W+ G +LY +++G PF + +K+ E + ++P+ ++ S A+ L Sbjct: 209 DEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQ--WKKVSEPAKDLI 266 Query: 421 SQLLCKDPAERLGCRGGSAREVKEHPLFK 449 ++L P R+ SAR+ EH K Sbjct: 267 RKMLAYVPTMRI-----SARDALEHEWLK 290 >1KOB-A nrPDB Length = 387 Score = 126 bits (317), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 89/299 (29%), Positives = 143/299 (47%), Gaps = 31/299 (10%) Query: 167 FNRFLQ--WKWLERQPV---TKNTFRQYRVL---GKGGFGEVCACQVRATGKMYACK--- 215 +++F + WK QPV + + Y +L G G FG V C +ATG+++ K Sbjct: 26 YDKFYEDIWKKYVPQPVEVKQGSVYDYYDILEELGSGAFGVVHRCVEKATGRVFVAKFIN 85 Query: 216 ---KLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLK 272 L+K +K NE I+ +++ +++L A+E K + L+L ++GG+L Sbjct: 86 TPYPLDKYTVK---------NEISIMNQLHHPKLINLHDAFEDKYEMVLILEFLSGGEL- 135 Query: 273 FHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDH--GHIRISDL 330 F EA + Y + C GL+ +H IV+ D+KPENI+ + ++I D Sbjct: 136 FDRIAAEDYKMSEAEVINYMRQACEGLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDF 195 Query: 331 GLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKK 390 GLA + + +K T + APE+V E F D WA+G L Y +++G SPF Sbjct: 196 GLATKLNPDEIVKVTTATAEFAAPEIVDREPVGFYTDMWAIGVLGYVLLSGLSPFAGEDD 255 Query: 391 KIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFK 449 + V+R E E+ SP+A+ LL K+P +RL + + EHP K Sbjct: 256 LETLQNVKRCDWEFDEDAFSSVSPEAKDFIKNLLQKEPRKRL-----TVHDALEHPWLK 309 >2J90-A nrPDB Length = 304 Score = 126 bits (316), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 79/261 (30%), Positives = 132/261 (50%), Gaps = 9/261 (3%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKK-RKGEAMALNEKQ- 236 Q + ++ + LG G F V C+ + TGK YA K ++K+R+ R+G + E++ Sbjct: 21 QSMVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREV 80 Query: 237 -ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEI 295 IL ++ +++L +E K + L+L L++GG+L + + E A + +I Sbjct: 81 NILREIRHPNIITLHDIFENKTDVVLILELVSGGEL--FDFLAEKESLTEDEATQFLKQI 138 Query: 296 CCGLEDLHRERIVYRDLKPENILLDDHG----HIRISDLGLAVHVPEGQTIKGRVGTVGY 351 G+ LH +RI + DLKPENI+L D I++ D G+A + G K GT + Sbjct: 139 LDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEF 198 Query: 352 MAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSER 411 +APE+V E D W++G + Y +++G SPF K+ + + + EEY Sbjct: 199 VAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSN 258 Query: 412 FSPQARSLCSQLLCKDPAERL 432 S A+ +LL KDP R+ Sbjct: 259 TSELAKDFIRRLLVKDPKRRM 279 >4RGJ-A nrPDB Length = 520 Score = 125 bits (315), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 82/275 (29%), Positives = 143/275 (52%), Gaps = 16/275 (5%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 ++ ++LGKG FGEV + + TG YA K + KK +K++ + L E ++L+ ++ Sbjct: 62 YKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHIN 121 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 ++ L +E + LV + GG+L I + + F E A +I G+ +H+ Sbjct: 122 IMKLYEFFEDNNYYYLVSDVYTGGELFDEI--ISRKRFYEIDAARIIKQILSGITYMHKN 179 Query: 306 RIVYRDLKPENILLDDHGH----IRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER 361 +V+RDLKPENILL+ I+I D GL+ H + +K ++GT Y+AP+V+ Sbjct: 180 NVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHG-T 238 Query: 362 YTFSPDWWALGCLLYEMIAGQSPFQQRKKK--IKREEVERLVKEVPEEYSERFSPQARSL 419 Y D W+ G +LY +++G PF + +K+ E + ++P+ ++ S +A+ L Sbjct: 239 YDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVEAGKYTFDLPQ--FKKISDKAKDL 296 Query: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFK 454 ++L A R+ SAR+ EH K + K Sbjct: 297 IKKMLMYTSAVRI-----SARDALEHEWIKMMTSK 326 >2WQN-A nrPDB Length = 310 Score = 125 bits (314), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 80/256 (31%), Positives = 126/256 (49%), Gaps = 10/256 (3%) Query: 184 NTFRQYRV---LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 NT +R+ +G+G F EV G A KK++ + K A + E +L++ Sbjct: 29 NTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQ 88 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG--FPEARAVFYAAEICCG 298 +N V+ ++ + L +VL L + GDL I H + PE Y ++C Sbjct: 89 LNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSA 148 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT-IKGRVGTVGYMAPEVV 357 LE +H R+++RD+KP N+ + G +++ DLGL T VGT YM+PE + Sbjct: 149 LEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERI 208 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKR--EEVERLVKEVPEEYSERFSPQ 415 Y F D W+LGCLLYEM A QSPF K + +++E+ + P S+ +S + Sbjct: 209 HENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQC--DYPPLPSDHYSEE 266 Query: 416 ARSLCSQLLCKDPAER 431 R L + + DP +R Sbjct: 267 LRQLVNMCINPDPEKR 282 >2Y7J-A nrPDB Length = 365 Score = 124 bits (312), Expect = 8e-29, Method: Compositional matrix adjust. Identities = 88/273 (32%), Positives = 141/273 (51%), Gaps = 21/273 (7%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLE--KKRIKKRKGEAM---ALNEKQILEKVNSR- 244 V+G+G V C RATG +A K +E +R+ + E + E IL +V Sbjct: 101 VIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHP 160 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 +++L +YE+ + LV LM G+L ++ E R++ + + + LH Sbjct: 161 HIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRS--LLEAVSFLHA 218 Query: 305 ERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVK------ 358 IV+RDLKPENILLDD+ IR+SD G + H+ G+ ++ GT GY+APE++K Sbjct: 219 NNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDET 278 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIK-REEVERLVKEVPEEYSERFSPQAR 417 + Y D WA G +L+ ++AG PF R++ + R +E + E+ +R S + Sbjct: 279 HPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDR-SSTVK 337 Query: 418 SLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 L S+LL DP RL +A + +HP F++ Sbjct: 338 DLISRLLQVDPEARL-----TAEQALQHPFFER 365 >3DXN-A nrPDB Length = 287 Score = 124 bits (312), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 83/273 (30%), Positives = 141/273 (51%), Gaps = 15/273 (5%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + +++ + LG G +GEV C+ + TG A K ++K + L+E +L++++ Sbjct: 21 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 80 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 ++ L +E K LV+ + GG+L I + + F E A ++ G LH Sbjct: 81 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEI--ILRQKFSEVDAAVIMKQVLSGTTYLH 138 Query: 304 RERIVYRDLKPENILLDDHGH---IRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE 360 + IV+RDLKPEN+LL+ I+I D GL+ H G +K R+GT Y+APEV++ + Sbjct: 139 KHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVLR-K 197 Query: 361 RYTFSPDWWALGCLLYEMIAGQSPF--QQRKKKIKREEVERLVKEVPEEYSERFSPQARS 418 +Y D W+ G +LY ++ G PF Q ++ +KR E + + P+ + S +A+ Sbjct: 198 KYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPD--WTQVSDEAKQ 255 Query: 419 LCSQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 L +L +P++R+ SA E HP K Sbjct: 256 LVKLMLTYEPSKRI-----SAEEALNHPWIVKF 283 >3GUB-A nrPDB Length = 295 Score = 124 bits (311), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 86/279 (30%), Positives = 137/279 (49%), Gaps = 14/279 (5%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKK-RKGEAMALNEKQ 236 RQ + + LG G F V C+ ++TG YA K ++K+R K R+G + E++ Sbjct: 5 RQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIERE 64 Query: 237 --ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAE 294 IL+++ V++L YE K + L+ L+ GG+L + + E A + + Sbjct: 65 VSILKEIQHPNVITLHEVYENKTDVILIGELVAGGEL--FDFLAEKESLTEEEATEFLKQ 122 Query: 295 ICCGLEDLHRERIVYRDLKPENILLDDHG----HIRISDLGLAVHVPEGQTIKGRVGTVG 350 I G+ LH +I + DLKPENI+L D I+I D GLA + G K GT Sbjct: 123 ILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPE 182 Query: 351 YMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE 410 ++APE+V E D W++G + Y +++G SPF K+ V + E +EY Sbjct: 183 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFS 242 Query: 411 RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFK 449 S A+ +LL KDP +R+ + ++ +HP K Sbjct: 243 NTSALAKDFIRRLLVKDPKKRM-----TIQDSLQHPWIK 276 >3HZT-A nrPDB Length = 467 Score = 124 bits (311), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 83/273 (30%), Positives = 141/273 (51%), Gaps = 15/273 (5%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + +++ + LG G +GEV C+ + TG A K ++K + L+E +L++++ Sbjct: 4 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 63 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 ++ L +E K LV+ + GG+L I + + F E A ++ G LH Sbjct: 64 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEI--ILRQKFSEVDAAVIMKQVLSGTTYLH 121 Query: 304 RERIVYRDLKPENILLDDHGH---IRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE 360 + IV+RDLKPEN+LL+ I+I D GL+ H G +K R+GT Y+APEV++ + Sbjct: 122 KHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVLR-K 180 Query: 361 RYTFSPDWWALGCLLYEMIAGQSPF--QQRKKKIKREEVERLVKEVPEEYSERFSPQARS 418 +Y D W+ G +LY ++ G PF Q ++ +KR E + + P+ + S +A+ Sbjct: 181 KYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPD--WTQVSDEAKQ 238 Query: 419 LCSQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 L +L +P++R+ SA E HP K Sbjct: 239 LVKLMLTYEPSKRI-----SAEEALNHPWIVKF 266 >1ZWS-A nrPDB Length = 288 Score = 122 bits (307), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 80/262 (30%), Positives = 134/262 (51%), Gaps = 14/262 (5%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIK-KRKGEAMALNEKQ--ILEKVNSRFVVS 248 LG G F V C+ ++TG YA K ++K++ + R+G + E++ IL +V V++ Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVIT 79 Query: 249 LAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIV 308 L YE + + L+L L++GG+L + + E A + +I G+ LH ++I Sbjct: 80 LHDVYENRTDVVLILELVSGGEL--FDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIA 137 Query: 309 YRDLKPENILLDDHG----HIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTF 364 + DLKPENI+L D HI++ D GLA + +G K GT ++APE+V E Sbjct: 138 HFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGL 197 Query: 365 SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLL 424 D W++G + Y +++G SPF K+ + + + EE+ S A+ +LL Sbjct: 198 EADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEEFFSHTSELAKDFIRKLL 257 Query: 425 CKDPAERLGCRGGSAREVKEHP 446 K+ +RL + +E HP Sbjct: 258 VKETRKRL-----TIQEALRHP 274 >2A27-A nrPDB Length = 321 Score = 122 bits (307), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 80/262 (30%), Positives = 135/262 (51%), Gaps = 14/262 (5%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIK-KRKGEAMALNEKQ--ILEKVNSRFVVS 248 LG G F V C+ ++TG YA K ++K++ + R+G + E++ IL +V V++ Sbjct: 20 LGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVIT 79 Query: 249 LAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIV 308 L YE + + L+L L++GG+L + + E A + +I G+ LH ++I Sbjct: 80 LHDVYENRTDVVLILELVSGGEL--FDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIA 137 Query: 309 YRDLKPENILLDDHG----HIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTF 364 + DLKPENI+L D HI++ D GLA + +G K GT ++APE+V E Sbjct: 138 HFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGL 197 Query: 365 SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLL 424 D W++G + Y +++G SPF K+ + + + EE+ + S A+ +LL Sbjct: 198 EADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLL 257 Query: 425 CKDPAERLGCRGGSAREVKEHP 446 K+ +RL + +E HP Sbjct: 258 VKETRKRL-----TIQEALRHP 274 >2JAM-A nrPDB Length = 304 Score = 122 bits (306), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 79/255 (30%), Positives = 131/255 (51%), Gaps = 9/255 (3%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 + TF VLG G F EV + R TGK++A K ++K + ++ NE +L+K+ Sbjct: 8 RKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFR---DSSLENEIAVLKKIK 64 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 +V+L YE+ LV+ L++GG+L I G + E A ++ ++ L Sbjct: 65 HENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGV--YTEKDASLVIQQVLSAVKYL 122 Query: 303 HRERIVYRDLKPENILL---DDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359 H IV+RDLKPEN+L +++ I I+D GL+ + + + GT GY+APEV+ Sbjct: 123 HENGIVHRDLKPENLLYLTPEENSKIMITDFGLS-KMEQNGIMSTACGTPGYVAPEVLAQ 181 Query: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419 + Y+ + D W++G + Y ++ G PF + + E+++ E + + S A+ Sbjct: 182 KPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDF 241 Query: 420 CSQLLCKDPAERLGC 434 LL KDP ER C Sbjct: 242 ICHLLEKDPNERYTC 256 >4FG9-A nrPDB Length = 320 Score = 121 bits (304), Expect = 7e-28, Method: Compositional matrix adjust. Identities = 80/264 (30%), Positives = 133/264 (50%), Gaps = 8/264 (3%) Query: 174 KWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALN 233 +W + + + ++ + VLG G F EV + + T K+ A K + K+ ++ ++G N Sbjct: 9 RWKQAEDI-RDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSME--N 65 Query: 234 EKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAA 293 E +L K+ +V+L YE+ L L++ L++GG+L I G + E A Sbjct: 66 EIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKG--FYTERDASRLIF 123 Query: 294 EICCGLEDLHRERIVYRDLKPENIL---LDDHGHIRISDLGLAVHVPEGQTIKGRVGTVG 350 ++ ++ LH IV+RDLKPEN+L LD+ I ISD GL+ G + GT G Sbjct: 124 QVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPG 183 Query: 351 YMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE 410 Y+APEV+ + Y+ + D W++G + Y ++ G PF E++ + E Y + Sbjct: 184 YVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWD 243 Query: 411 RFSPQARSLCSQLLCKDPAERLGC 434 S A+ L+ KDP +R C Sbjct: 244 DISDSAKDFIRHLMEKDPEKRFTC 267 >3NCG-A nrPDB Length = 486 Score = 120 bits (301), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 84/265 (31%), Positives = 137/265 (51%), Gaps = 16/265 (6%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLA 250 +LGKG FGEV C+ R T + YA K + K K K + L E ++L+K++ ++ L Sbjct: 29 MLGKGSFGEVLKCKDRITQQEYAVKVINKAS-AKNKDTSTILREVELLKKLDHPNIMKLF 87 Query: 251 YAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYR 310 E + +V L GG+L I + + F E A ++ G+ +H+ IV+R Sbjct: 88 EILEDSSSFYIVGELYTGGELFDEI--IKRKRFSEHDAARIIKQVFSGITYMHKHNIVHR 145 Query: 311 DLKPENILLDDHG---HIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPD 367 DLKPENILL+ I+I D GL+ + +K R+GT Y+APEV++ Y D Sbjct: 146 DLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRG-TYDEKCD 204 Query: 368 WWALGCLLYEMIAGQSPFQQRKKK--IKREEVERLVKEVPEEYSERFSPQARSLCSQLLC 425 W+ G +LY +++G PF + + +KR E + ++P+ + S A+ L ++L Sbjct: 205 VWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRT--ISDDAKDLIRKMLT 262 Query: 426 KDPAERLGCRGGSAREVKEHPLFKK 450 P+ R+ +A + EHP +K Sbjct: 263 FHPSLRI-----TATQCLEHPWIQK 282 >2YAB-A nrPDB Length = 361 Score = 120 bits (301), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 83/278 (29%), Positives = 140/278 (50%), Gaps = 23/278 (8%) Query: 185 TFRQYRV---------LGKGGFGEVCACQVRATGKMYACKKLEKKRIK-KRKGEAMALNE 234 TF+Q +V LG G F V C+ ++TG YA K ++K++ + R+G E Sbjct: 4 TFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIE 63 Query: 235 KQ--ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYA 292 ++ IL +V +++L YE + + L+L L++GG+L + + E A + Sbjct: 64 REVSILRQVLHPNIITLHDVYENRTDVVLILELVSGGEL--FDFLAQKESLSEEEATSFI 121 Query: 293 AEICCGLEDLHRERIVYRDLKPENILLDDHG----HIRISDLGLAVHVPEGQTIKGRVGT 348 +I G+ LH ++I + DLKPENI+L D HI++ D GLA + +G K GT Sbjct: 122 KQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGT 181 Query: 349 VGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEY 408 ++APE+V E D W++G + Y +++G SPF K+ + + + EE+ Sbjct: 182 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEF 241 Query: 409 SERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHP 446 + S A+ +LL K+ +RL + +E HP Sbjct: 242 FSQTSELAKDFIRKLLVKETRKRL-----TIQEALRHP 274 >3DFA-A nrPDB Length = 286 Score = 120 bits (301), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 84/265 (31%), Positives = 137/265 (51%), Gaps = 16/265 (6%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLA 250 +LGKG FGEV C+ R T + YA K + K K K + L E ++L+K++ ++ L Sbjct: 29 MLGKGSFGEVLKCKDRITQQEYAVKVINKAS-AKNKDTSTILREVELLKKLDHPNIMKLF 87 Query: 251 YAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYR 310 E + +V L GG+L I + + F E A ++ G+ +H+ IV+R Sbjct: 88 EILEDSSSFYIVGELYTGGELFDEI--IKRKRFSEHDAARIIKQVFSGITYMHKHNIVHR 145 Query: 311 DLKPENILLDDHG---HIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPD 367 DLKPENILL+ I+I D GL+ + +K R+GT Y+APEV++ Y D Sbjct: 146 DLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRGT-YDEKCD 204 Query: 368 WWALGCLLYEMIAGQSPFQQRKKK--IKREEVERLVKEVPEEYSERFSPQARSLCSQLLC 425 W+ G +LY +++G PF + + +KR E + ++P+ + S A+ L ++L Sbjct: 205 VWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRT--ISDDAKDLIRKMLT 262 Query: 426 KDPAERLGCRGGSAREVKEHPLFKK 450 P+ R+ +A + EHP +K Sbjct: 263 FHPSLRI-----TATQCLEHPWIQK 282 >3TAC-A nrPDB Length = 361 Score = 120 bits (301), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 85/268 (31%), Positives = 129/268 (48%), Gaps = 14/268 (5%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAM--ALNEKQILEKVNSRFVVS 248 V+GKG F V C R TG+ +A K ++ + G + E I + +V Sbjct: 33 VIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVE 92 Query: 249 LAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGF--PEARAVFYAAEICCGLEDLHRER 306 L Y + L +V M+G DL F I AGF EA A Y +I L H Sbjct: 93 LLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNN 152 Query: 307 IVYRDLKPENILL---DDHGHIRISDLGLAVHVPE-GQTIKGRVGTVGYMAPEVVKNERY 362 I++RD+KP +LL ++ +++ G+A+ + E G GRVGT +MAPEVVK E Y Sbjct: 153 IIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPY 212 Query: 363 TFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQ 422 D W G +L+ +++G PF K+++ ++ K P ++S S A+ L + Sbjct: 213 GKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWS-HISESAKDLVRR 271 Query: 423 LLCKDPAERLGCRGGSAREVKEHPLFKK 450 +L DPAER+ + E HP K+ Sbjct: 272 MLMLDPAERI-----TVYEALNHPWLKE 294 >2X4F-A nrPDB Length = 373 Score = 119 bits (299), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 77/264 (29%), Positives = 135/264 (51%), Gaps = 11/264 (4%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 T + +LG G FG+V C+ ATG A K ++ + +K ++ NE ++ +++ Sbjct: 90 TVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEE---VKNEISVMNQLDHA 146 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 ++ L A+E+K+ + LV+ ++GG+L I E + + +IC G+ +H+ Sbjct: 147 NLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESY-NLTELDTILFMKQICEGIRHMHQ 205 Query: 305 ERIVYRDLKPENILL--DDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERY 362 I++ DLKPENIL D I+I D GLA + +K GT ++APEVV + Sbjct: 206 MYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFV 265 Query: 363 TFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQ 422 +F D W++G + Y +++G SPF + ++ +E + S +A+ S+ Sbjct: 266 SFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISK 325 Query: 423 LLCKDPAERLGCRGGSAREVKEHP 446 LL K+ + R+ SA E +HP Sbjct: 326 LLIKEKSWRI-----SASEALKHP 344 >4B6L-A nrPDB Length = 281 Score = 119 bits (297), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 82/273 (30%), Positives = 130/273 (47%), Gaps = 14/273 (5%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 P + T+ + R+LGKGGF TG YA K + + R+ K LNE ++ Sbjct: 5 PRSGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHR 64 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGF-PEARAVFYAAEICCG 298 + R +V ++ +E D + + L L + L HI+ PE R +Y +I G Sbjct: 65 DLQHRHIVRFSHHFEDADNIYIFLELCSRKSLA-HIWKARHTLLEPEVR--YYLRQILSG 121 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV-PEGQTIKGRVGTVGYMAPEVV 357 L+ LH+ I++RDLK N + ++ +++ D GLA + P Q K GT Y+APEV+ Sbjct: 122 LKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVL 181 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 + + D W+LGC++Y ++ G PF+ K E R +K+V S AR Sbjct: 182 LRQGHGPEADVWSLGCVMYTLLCGSPPFETADLK----ETYRCIKQVHYTLPASLSLPAR 237 Query: 418 SLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 L + +L P +R S ++ H F K Sbjct: 238 QLLAAILRASPRDR-----PSIDQILRHDFFTK 265 >5XZW-A nrPDB Length = 471 Score = 117 bits (293), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 82/278 (29%), Positives = 133/278 (47%), Gaps = 38/278 (13%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLA 250 V+G+G F V R TGK +A K + K+++ E ++L+K+N +V L Sbjct: 203 VVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVT--RELEVLQKLNHPRIVRLK 260 Query: 251 YAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYR 310 YE ++ +V+ ++GGDL + G G R + + +I ++ +H I +R Sbjct: 261 GFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREI--SRQILTAIKYIHSMGISHR 318 Query: 311 DLKPENILL--DDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSP-- 366 DLKP+NIL+ DD ++I+D GLA G +K GT+ Y+APEV++ + + SP Sbjct: 319 DLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDE 378 Query: 367 -----------DWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPE-EYSE---- 410 D W++GCL+Y ++ G PF + ++L K++ Y E Sbjct: 379 YEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQ-------DQLYKQIGRGSYHEGPLK 431 Query: 411 --RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHP 446 R S +AR LL DP R +A + HP Sbjct: 432 DFRISEEARDFIDSLLQVDPNNR-----STAAKALNHP 464 >5FG8-A nrPDB Length = 285 Score = 117 bits (292), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 79/259 (30%), Positives = 135/259 (52%), Gaps = 12/259 (4%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 LGKG F V C ++TG +A K + K++ R + + E +I K++ +V L Sbjct: 22 LGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLE-REARICRKLHHPNIVRLHD 80 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 + + ++ LV L+ GG+L I + + + EA A +I + H+ +V+RD Sbjct: 81 SIQEENYHYLVFDLVTGGELFEDI--VAREFYSEADASHCIQQILESVNHCHQNGVVHRD 138 Query: 312 LKPENILLDDHGH---IRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKNERYTFSPD 367 LKPEN+LL ++++D GLA+ V + Q G GT GY++PEV+K E Y S D Sbjct: 139 LKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVD 198 Query: 368 WWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKD 427 WA G +LY ++ G PF + +++ + P + +P+A++L +Q+L + Sbjct: 199 IWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVN 258 Query: 428 PAERLGCRGGSAREVKEHP 446 P +R+ +A E +HP Sbjct: 259 PNKRI-----TAAEALKHP 272 >4REW-A nrPDB Length = 540 Score = 116 bits (291), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 78/264 (29%), Positives = 133/264 (50%), Gaps = 18/264 (6%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLA 250 LG G FG+V + TG A K L +++I+ E Q L+ ++ L Sbjct: 13 TLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLY 72 Query: 251 YAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYR 310 T + +V+ ++GG+L +I G+ E+R +F +I G++ HR +V+R Sbjct: 73 QVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLF--QQILSGVDYCHRHMVVHR 130 Query: 311 DLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTF-SPDWW 369 DLKPEN+LLD H + +I+D GL+ + +G+ ++ G+ Y APEV+ Y D W Sbjct: 131 DLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 190 Query: 370 ALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEE--YSERF-SPQARSLCSQLLCK 426 + G +LY ++ G PF + V L K++ + Y+ ++ +P SL +L Sbjct: 191 SSGVILYALLCGTLPFDD-------DHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQV 243 Query: 427 DPAERLGCRGGSAREVKEHPLFKK 450 DP +R S ++++EH FK+ Sbjct: 244 DPMKR-----ASIKDIREHEWFKQ 262 >4XBR-A nrPDB Length = 366 Score = 116 bits (290), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 75/264 (28%), Positives = 130/264 (49%), Gaps = 21/264 (7%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 +G+G G VC VR++GK+ A KK++ ++ ++R+ + NE I+ VV + Sbjct: 102 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRE---LLFNEVVIMRDYQHENVVEMYN 158 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 +Y D L +V+ + GG L + H E + + L LH + +++RD Sbjct: 159 SYLVGDELWVVMEFLEGGALTDIVTH---TRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 215 Query: 312 LKPENILLDDHGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWA 370 +K ++ILL G +++SD G V E K VGT +MAPE++ Y D W+ Sbjct: 216 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWS 275 Query: 371 LGCLLYEMIAGQSPFQQ----RKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCK 426 LG ++ EM+ G+ P+ + K+ R+ + +K + + SP + +LL + Sbjct: 276 LGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNL-----HKVSPSLKGFLDRLLVR 330 Query: 427 DPAERLGCRGGSAREVKEHPLFKK 450 DPA+R +A E+ +HP K Sbjct: 331 DPAQR-----ATAAELLKHPFLAK 349 >4RED-A nrPDB Length = 351 Score = 115 bits (289), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 78/263 (29%), Positives = 133/263 (50%), Gaps = 18/263 (6%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 LG G FG+V + TG A K L +++I+ E Q L+ ++ L Sbjct: 22 LGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 81 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 T + +V+ ++GG+L +I G+ E+R +F +I G++ HR +V+RD Sbjct: 82 VISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLF--QQILSGVDYCHRHMVVHRD 139 Query: 312 LKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTF-SPDWWA 370 LKPEN+LLD H + +I+D GL+ + +G+ ++ G+ Y APEV+ Y D W+ Sbjct: 140 LKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS 199 Query: 371 LGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEE--YSERF-SPQARSLCSQLLCKD 427 G +LY ++ G PF + V L K++ + Y+ ++ +P SL +L D Sbjct: 200 SGVILYALLCGTLPFDD-------DHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVD 252 Query: 428 PAERLGCRGGSAREVKEHPLFKK 450 P +R S ++++EH FK+ Sbjct: 253 PMKR-----ASIKDIREHEWFKQ 270 >4FIE-A nrPDB Length = 423 Score = 115 bits (289), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 75/264 (28%), Positives = 130/264 (49%), Gaps = 21/264 (7%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 +G+G G VC VR++GK+ A KK++ ++ ++R+ + NE I+ VV + Sbjct: 159 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRE---LLFNEVVIMRDYQHENVVEMYN 215 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 +Y D L +V+ + GG L + H E + + L LH + +++RD Sbjct: 216 SYLVGDELWVVMEFLEGGALTDIVTH---TRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 272 Query: 312 LKPENILLDDHGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWA 370 +K ++ILL G +++SD G V E K VGT +MAPE++ Y D W+ Sbjct: 273 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWS 332 Query: 371 LGCLLYEMIAGQSPFQQ----RKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCK 426 LG ++ EM+ G+ P+ + K+ R+ + +K + + SP + +LL + Sbjct: 333 LGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNL-----HKVSPSLKGFLDRLLVR 387 Query: 427 DPAERLGCRGGSAREVKEHPLFKK 450 DPA+R +A E+ +HP K Sbjct: 388 DPAQR-----ATAAELLKHPFLAK 406 >4JDH-A nrPDB Length = 346 Score = 115 bits (288), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 75/264 (28%), Positives = 130/264 (49%), Gaps = 21/264 (7%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 +G+G G VC VR++GK+ A KK++ ++ ++R+ + NE I+ VV + Sbjct: 82 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRE---LLFNEVVIMRDYQHENVVEMYN 138 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 +Y D L +V+ + GG L + H E + + L LH + +++RD Sbjct: 139 SYLVGDELWVVMEFLEGGALTDIVTH---TRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 195 Query: 312 LKPENILLDDHGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWA 370 +K ++ILL G +++SD G V E K VGT +MAPE++ Y D W+ Sbjct: 196 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWS 255 Query: 371 LGCLLYEMIAGQSPFQQ----RKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCK 426 LG ++ EM+ G+ P+ + K+ R+ + +K + + SP + +LL + Sbjct: 256 LGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNL-----HKVSPSLKGFLDRLLVR 310 Query: 427 DPAERLGCRGGSAREVKEHPLFKK 450 DPA+R +A E+ +HP K Sbjct: 311 DPAQR-----ATAAELLKHPFLAK 329 >2Q0N-A nrPDB Length = 301 Score = 115 bits (288), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 75/264 (28%), Positives = 130/264 (49%), Gaps = 21/264 (7%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 +G+G G VC VR++GK+ A KK++ ++ ++R+ + NE I+ VV + Sbjct: 37 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRE---LLFNEVVIMRDYQHENVVEMYN 93 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 +Y D L +V+ + GG L + H E + + L LH + +++RD Sbjct: 94 SYLVGDELWVVMEFLEGGALTDIVTH---TRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 150 Query: 312 LKPENILLDDHGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWA 370 +K ++ILL G +++SD G V E K VGT +MAPE++ Y D W+ Sbjct: 151 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWS 210 Query: 371 LGCLLYEMIAGQSPFQQ----RKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCK 426 LG ++ EM+ G+ P+ + K+ R+ + +K + + SP + +LL + Sbjct: 211 LGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNL-----HKVSPSLKGFLDRLLVR 265 Query: 427 DPAERLGCRGGSAREVKEHPLFKK 450 DPA+R +A E+ +HP K Sbjct: 266 DPAQR-----ATAAELLKHPFLAK 284 >4CFH-A nrPDB Length = 493 Score = 115 bits (288), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 77/264 (29%), Positives = 133/264 (50%), Gaps = 18/264 (6%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLA 250 LG G FG+V + TG A K L +++I+ E Q L+ ++ L Sbjct: 40 TLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLY 99 Query: 251 YAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYR 310 T + +V+ ++GG+L +I G+ E+R +F +I G++ HR +V+R Sbjct: 100 QVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLF--QQILSGVDYCHRHMVVHR 157 Query: 311 DLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTF-SPDWW 369 DLKPEN+LLD H + +I+D GL+ + +G+ ++ G+ Y APEV+ Y D W Sbjct: 158 DLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 217 Query: 370 ALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEE--YSERF-SPQARSLCSQLLCK 426 + G +LY ++ G PF + V L K++ + Y+ ++ +P SL +L Sbjct: 218 SSGVILYALLCGTLPFDD-------DHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQV 270 Query: 427 DPAERLGCRGGSAREVKEHPLFKK 450 DP +R + ++++EH FK+ Sbjct: 271 DPMKR-----ATIKDIREHEWFKQ 289 >3LIJ-A nrPDB Length = 494 Score = 114 bits (285), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 81/271 (29%), Positives = 139/271 (51%), Gaps = 16/271 (5%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 +++ + LG G +GEV C+ + T A K + K + + L E +L+ ++ Sbjct: 39 YQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKL-LEEVAVLKLLDHPN 97 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 ++ L +E K LV+ GG+L I H + F E A ++ G+ LH+ Sbjct: 98 IMKLYDFFEDKRNYYLVMECYKGGELFDEIIH--RMKFNEVDAAVIIKQVLSGVTYLHKH 155 Query: 306 RIVYRDLKPENILLDD---HGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERY 362 IV+RDLKPEN+LL+ I+I D GL+ + +K R+GT Y+APEV++ ++Y Sbjct: 156 NIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEVLR-KKY 214 Query: 363 TFSPDWWALGCLLYEMIAGQSPF--QQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC 420 D W++G +L+ ++AG PF Q ++ +++ E + + PE + S A+ L Sbjct: 215 DEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSPE--WKNVSEGAKDLI 272 Query: 421 SQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 Q+L D R+ SA++ EHP K++ Sbjct: 273 KQMLQFDSQRRI-----SAQQALEHPWIKEM 298 >4PDS-A nrPDB Length = 347 Score = 114 bits (284), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 80/275 (29%), Positives = 130/275 (47%), Gaps = 26/275 (9%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKR-IKKRKGEAMALNEKQILEKVNSRFVVSL 249 V+G+G F V R TGK ++ K + K++ I G E ++L+K+N +V L Sbjct: 38 VVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDG---VTRELEVLQKLNHPRIVRL 94 Query: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 YE ++ +V+ ++GGDL + G G R + + +I ++ +H I + Sbjct: 95 KGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREI--SRQILTAIKYIHSMGISH 152 Query: 310 RDLKPENILL--DDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSP- 366 RDLKP+NIL+ DD ++I+ GLA G +K GT+ Y+APEV++ + + SP Sbjct: 153 RDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPD 212 Query: 367 ------------DWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSP 414 D W++GCL+Y ++ G PF + +++ R R S Sbjct: 213 EYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISE 272 Query: 415 QARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFK 449 +AR LL DP R +A + HP K Sbjct: 273 EARDFIDSLLQVDPNNR-----STAAKALNHPWIK 302 >3D2K-A nrPDB Length = 272 Score = 113 bits (283), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 76/260 (29%), Positives = 125/260 (48%), Gaps = 12/260 (4%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 R LGKG FG V + R + + A K L K +++K E E +I + ++ L Sbjct: 18 RPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRHPNILRL 77 Query: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 + + L+L G + + + + F E R Y E+ L H +R+++ Sbjct: 78 YGYFHDATRVYLILEYAPLGTVYRELQKLSR--FDEQRTATYITELANALSYCHSKRVIH 135 Query: 310 RDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWW 369 RD+KPEN+LL +G ++I+D G +VH P + GT+ Y+ PE+++ + D W Sbjct: 136 RDIKPENLLLGSNGELKIADFGWSVHAPSSRRTT-LCGTLDYLPPEMIEGRMHDEKVDLW 194 Query: 370 ALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPA 429 +LG L YE + G PF+ +E R + V + + + AR L S+LL + + Sbjct: 195 SLGVLCYEFLVGMPPFEAHTY----QETYRRISRVEFTFPDFVTEGARDLISRLLKHNAS 250 Query: 430 ERLGCRGGSAREVKEHPLFK 449 +RL + EV EHP K Sbjct: 251 QRL-----TLAEVLEHPWIK 265 >3BHH-A nrPDB Length = 295 Score = 113 bits (283), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 78/267 (29%), Positives = 134/267 (50%), Gaps = 12/267 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + ++ Y +GKG F V C TG YA K + K++ R + + E +I + Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLE-REARICRLLKH 62 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 +V L + + LV L+ GG+L I + + + EA A +I + H Sbjct: 63 SNIVRLHDSISEEGFHYLVFDLVTGGELFEDI--VAREYYSEADASHCIQQILEAVLHCH 120 Query: 304 RERIVYRDLKPENILLDDH---GHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKN 359 + +V+RDLKPEN+LL ++++D GLA+ V + Q G GT GY++PEV++ Sbjct: 121 QMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 180 Query: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419 E Y D WA G +LY ++ G PF + ++++ + P + +P+A++L Sbjct: 181 EAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 240 Query: 420 CSQLLCKDPAERLGCRGGSAREVKEHP 446 +Q+L +PA+R+ +A E +HP Sbjct: 241 INQMLTINPAKRI-----TAHEALKHP 262 >3KK8-A nrPDB Length = 284 Score = 113 bits (282), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 72/244 (29%), Positives = 123/244 (50%), Gaps = 6/244 (2%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 LGKG F V C + TG +A K + K++ R + + E +I K+ +V L Sbjct: 14 LGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLE-REARICRKLQHPNIVRLHD 72 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 + + + LV L+ GG+L I + + + EA A +I + H IV+R+ Sbjct: 73 SIQEESFHYLVFDLVTGGELFEDI--VAREFYSEADASHCIQQILESIAYCHSNGIVHRN 130 Query: 312 LKPENILLDDHGH---IRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDW 368 LKPEN+LL ++++D GLA+ V + + G GT GY++PEV+K + Y+ D Sbjct: 131 LKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPYSKPVDI 190 Query: 369 WALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDP 428 WA G +LY ++ G PF + +++ + P + +P+A+SL +L +P Sbjct: 191 WACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNP 250 Query: 429 AERL 432 +R+ Sbjct: 251 KKRI 254 >3H4J-B nrPDB Length = 336 Score = 112 bits (281), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 77/259 (29%), Positives = 129/259 (49%), Gaps = 13/259 (5%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 LG+G FG+V T + A K + ++ +KK E L+ + ++ L Sbjct: 17 LGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPHIIKLYD 76 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 T + +V+ GG+L +I + E R F +I C +E HR +IV+RD Sbjct: 77 VITTPTDIVMVIEYA-GGELFDYIVEKKRMTEDEGRRFF--QQIICAIEYCHRHKIVHRD 133 Query: 312 LKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTF-SPDWWA 370 LKPEN+LLDD+ +++I+D GL+ + +G +K G+ Y APEV+ + Y D W+ Sbjct: 134 LKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAGPEVDVWS 193 Query: 371 LGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAE 430 G +LY M+ G+ PF ++V V +P + SP A+SL +++ DP + Sbjct: 194 CGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVYVMP----DFLSPGAQSLIRRMIVADPMQ 249 Query: 431 RLGCRGGSAREVKEHPLFK 449 R+ + +E++ P F Sbjct: 250 RI-----TIQEIRRDPWFN 263 >3MN3-A nrPDB Length = 271 Score = 112 bits (281), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 77/266 (28%), Positives = 129/266 (48%), Gaps = 13/266 (4%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 ++ + LG+G FG+V TG+ A K + KK + K + E L + Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHP 64 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 ++ L ++KD + +V+ G +L +I + EAR F +I +E HR Sbjct: 65 HIIKLYDVIKSKDEIIMVIEYA-GNELFDYIVQRDKMSEQEARRFF--QQIISAVEYCHR 121 Query: 305 ERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTF 364 +IV+RDLKPEN+LLD+H +++I+D GL+ + +G +K G+ Y APEV+ + Y Sbjct: 122 HKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAG 181 Query: 365 -SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQL 423 D W+ G +LY M+ + PF + + + V +P + SP A L ++ Sbjct: 182 PEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLP----KFLSPGAAGLIKRM 237 Query: 424 LCKDPAERLGCRGGSAREVKEHPLFK 449 L +P R+ S E+ + FK Sbjct: 238 LIVNPLNRI-----SIHEIMQDDWFK 258 >2BDW-A nrPDB Length = 362 Score = 112 bits (280), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 72/244 (29%), Positives = 123/244 (50%), Gaps = 6/244 (2%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 LGKG F V C + TG +A K + K++ R + + E +I K+ +V L Sbjct: 37 LGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLE-REARICRKLQHPNIVRLHD 95 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 + + + LV L+ GG+L I + + + EA A +I + H IV+R+ Sbjct: 96 SIQEESFHYLVFDLVTGGELFEDI--VAREFYSEADASHCIQQILESIAYCHSNGIVHRN 153 Query: 312 LKPENILLDDHGH---IRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDW 368 LKPEN+LL ++++D GLA+ V + + G GT GY++PEV+K + Y+ D Sbjct: 154 LKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPYSKPVDI 213 Query: 369 WALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDP 428 WA G +LY ++ G PF + +++ + P + +P+A+SL +L +P Sbjct: 214 WACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNP 273 Query: 429 AERL 432 +R+ Sbjct: 274 KKRI 277 >5ES1-A nrPDB Length = 328 Score = 112 bits (280), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 79/256 (30%), Positives = 128/256 (50%), Gaps = 9/256 (3%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 E QP N +R R +GKG F +V + TG+ A K ++K ++ + + E + Sbjct: 9 EEQPHVGN-YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKL-FREVR 66 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 I++ +N +V L ET+ L LV+ + G++ ++ G+ EARA F +I Sbjct: 67 IMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKF--RQIV 124 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 + H++ IV+RDLK EN+LLD +I+I+D G + G + G+ Y APE+ Sbjct: 125 SAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPEL 184 Query: 357 VKNERYTF-SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQ 415 + ++Y D W+LG +LY +++G PF K RE V R VP S Sbjct: 185 FQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVP----FYMSTD 240 Query: 416 ARSLCSQLLCKDPAER 431 S+ + L +PA+R Sbjct: 241 CESILRRFLVLNPAKR 256 >4UZD-A nrPDB Length = 287 Score = 112 bits (279), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 75/257 (29%), Positives = 125/257 (48%), Gaps = 12/257 (4%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 R LGKG FG V + + + + A K L K +++K E E +I + ++ L Sbjct: 14 RPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRL 73 Query: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 + + L+L G + + + + F E R Y E+ L H +R+++ Sbjct: 74 YGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCHSKRVIH 131 Query: 310 RDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWW 369 RD+KPEN+LL G ++I+D G +VH P + GT+ Y+ PE+++ + D W Sbjct: 132 RDIKPENLLLGSAGELKIADFGWSVHAPSSRRTT-LCGTLDYLPPEMIEGRMHDEKVDLW 190 Query: 370 ALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPA 429 +LG L YE + G+ PF+ + + + R+ P+ +E AR L S+LL +P+ Sbjct: 191 SLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTE----GARDLISRLLKHNPS 246 Query: 430 ERLGCRGGSAREVKEHP 446 +R REV EHP Sbjct: 247 QR-----PMLREVLEHP 258 >2V7O-A nrPDB Length = 336 Score = 112 bits (279), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 76/267 (28%), Positives = 135/267 (50%), Gaps = 12/267 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + ++ + LGKG F V C + + YA K + K++ R + + E +I + Sbjct: 31 DDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLE-REARICRLLKH 89 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 +V L + + LV L+ GG+L I + + + EA A +I + +H Sbjct: 90 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDI--VAREYYSEADASHCIHQILESVNHIH 147 Query: 304 RERIVYRDLKPENILLDDH---GHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKN 359 + IV+RDLKPEN+LL ++++D GLA+ V E Q G GT GY++PEV++ Sbjct: 148 QHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRK 207 Query: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419 + Y D WA G +LY ++ G PF + ++++ + P + +P+A++L Sbjct: 208 DPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 267 Query: 420 CSQLLCKDPAERLGCRGGSAREVKEHP 446 +Q+L +PA+R+ +A + +HP Sbjct: 268 INQMLTINPAKRI-----TADQALKHP 289 >4CFF-A nrPDB Length = 571 Score = 111 bits (278), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 76/261 (29%), Positives = 128/261 (49%), Gaps = 12/261 (4%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLA 250 LG G FG+V + + TG A K L +++I+ E Q L+ ++ L Sbjct: 40 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 99 Query: 251 YAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYR 310 T +V+ ++GG+L +I G+ EAR +F +I ++ HR +V+R Sbjct: 100 QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF--QQILSAVDYCHRHMVVHR 157 Query: 311 DLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTF-SPDWW 369 DLKPEN+LLD H + +I+D GL+ + +G+ ++ G+ Y APEV+ Y D W Sbjct: 158 DLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 217 Query: 370 ALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPA 429 + G +LY ++ G PF +++ V +P EY R +L +L DP Sbjct: 218 SCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP-EYLNR---SVATLLMHMLQVDPL 273 Query: 430 ERLGCRGGSAREVKEHPLFKK 450 +R + ++++EH FK+ Sbjct: 274 KR-----ATIKDIREHEWFKQ 289 >5EZV-A nrPDB Length = 560 Score = 111 bits (278), Expect = 8e-25, Method: Compositional matrix adjust. Identities = 76/261 (29%), Positives = 128/261 (49%), Gaps = 12/261 (4%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLA 250 LG G FG+V + + TG A K L +++I+ E Q L+ ++ L Sbjct: 35 TLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLY 94 Query: 251 YAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYR 310 T +V+ ++GG+L +I G+ EAR +F +I ++ HR +V+R Sbjct: 95 QVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF--QQILSAVDYCHRHMVVHR 152 Query: 311 DLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTF-SPDWW 369 DLKPEN+LLD H + +I+D GL+ + +G+ ++ G+ Y APEV+ Y D W Sbjct: 153 DLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 212 Query: 370 ALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPA 429 + G +LY ++ G PF +++ V +P EY R +L +L DP Sbjct: 213 SCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP-EYLNR---SVATLLMHMLQVDPL 268 Query: 430 ERLGCRGGSAREVKEHPLFKK 450 +R + ++++EH FK+ Sbjct: 269 KR-----ATIKDIREHEWFKQ 284 >2VN9-A nrPDB Length = 301 Score = 111 bits (277), Expect = 9e-25, Method: Compositional matrix adjust. Identities = 77/267 (28%), Positives = 133/267 (49%), Gaps = 12/267 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + ++ + LGKG F V C TG+ YA K + K++ R + + E +I + Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLE-REARICRLLKH 62 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 +V L + + LV L+ GG+L I + + + EA A +I + H Sbjct: 63 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDI--VAREYYSEADASHCIQQILESVNHCH 120 Query: 304 RERIVYRDLKPENILLDDH---GHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKN 359 IV+RDLKPEN+LL ++++D GLA+ V + Q G GT GY++PEV++ Sbjct: 121 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 180 Query: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419 + Y D WA G +LY ++ G PF + ++++ + P + +P+A+ L Sbjct: 181 DPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDL 240 Query: 420 CSQLLCKDPAERLGCRGGSAREVKEHP 446 +++L +PA+R+ +A E +HP Sbjct: 241 INKMLTINPAKRI-----TASEALKHP 262 >5IG1-A nrPDB Length = 344 Score = 111 bits (277), Expect = 9e-25, Method: Compositional matrix adjust. Identities = 74/263 (28%), Positives = 130/263 (49%), Gaps = 11/263 (4%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLA 250 V+GKG F V C + TG++ A K + K ++ + + E I + +VS+ Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIK-REIGICSSLQHEHIVSMR 82 Query: 251 YAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYR 310 A+ + LV ++GG+L I + + + E A +I L+ H + I++R Sbjct: 83 RAFRDESHFYLVFEYVSGGELFDEI--VTRKFYNEKDASACMHQILSALQHCHSKNIIHR 140 Query: 311 DLKPENILL---DDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPD 367 DLKPEN+LL D + ++I+D GLAV + +G T G GT GY++PEV++ Y + D Sbjct: 141 DLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRRVPYDTAVD 200 Query: 368 WWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKD 427 WA G +LY ++ G PF + + +++ + P + + A+ L +L + Sbjct: 201 VWACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPEWDSVTTAAKELIKAMLEPN 260 Query: 428 PAERLGCRGGSAREVKEHPLFKK 450 P R + +E+ +HP + Sbjct: 261 PKRR-----PTVQELLQHPWIAR 278 >2YZA-A nrPDB Length = 276 Score = 110 bits (276), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 76/260 (29%), Positives = 128/260 (49%), Gaps = 12/260 (4%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 LG G FG+V + + TG A K L +++I+ E Q L+ ++ L Sbjct: 19 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 78 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 T +V+ ++GG+L +I G+ EAR +F +I ++ HR +V+RD Sbjct: 79 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF--QQILSAVDYCHRHMVVHRD 136 Query: 312 LKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTF-SPDWWA 370 LKPEN+LLD H + +I+D GL+ + +G+ ++ G+ Y APEV+ Y D W+ Sbjct: 137 LKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRLYAGPEVDIWS 196 Query: 371 LGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAE 430 G +LY ++ G PF +++ V +P EY R +L +L DP + Sbjct: 197 CGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP-EYLNR---SVATLLMHMLQVDPLK 252 Query: 431 RLGCRGGSAREVKEHPLFKK 450 R + ++++EH FK+ Sbjct: 253 R-----ATIKDIREHEWFKQ 267 >1PHK-A nrPDB Length = 298 Score = 110 bits (276), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 80/274 (29%), Positives = 127/274 (46%), Gaps = 22/274 (8%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAM------ALNEKQILEKVNSR 244 +LG+G V C + T K YA K ++ E + L E IL KV+ Sbjct: 24 ILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDILRKVSGH 83 Query: 245 -FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAA-EICCGLEDL 302 ++ L YET LV LM G+L ++ E R + A E+ C L Sbjct: 84 PNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEVICAL--- 140 Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVK---- 358 H+ IV+RDLKPENILLDD +I+++D G + + G+ ++ GT Y+APE+++ Sbjct: 141 HKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPSYLAPEIIECSMN 200 Query: 359 --NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQA 416 + Y D W+ G ++Y ++AG PF RK+ + + + + +S Sbjct: 201 DNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYSDTV 260 Query: 417 RSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 + L S+ L P +R +A E HP F++ Sbjct: 261 KDLVSRFLVVQPQKRY-----TAEEALAHPFFQQ 289 >5KZ7-A nrPDB Length = 346 Score = 109 bits (273), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 77/256 (30%), Positives = 131/256 (51%), Gaps = 9/256 (3%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 + QP N +R + +GKG F +V + TGK A K ++K ++ + + E + Sbjct: 27 DEQPHIGN-YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKL-FREVR 84 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 I++ +N +V L ET+ L LV+ +GG++ ++ G+ EARA F +I Sbjct: 85 IMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKF--RQIV 142 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 ++ H++ IV+RDLK EN+LLD +I+I+D G + G + G+ Y APE+ Sbjct: 143 SAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPEL 202 Query: 357 VKNERYTF-SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQ 415 + ++Y D W+LG +LY +++G PF + K RE V R +P S Sbjct: 203 FQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIP----FYMSTD 258 Query: 416 ARSLCSQLLCKDPAER 431 +L + L +P++R Sbjct: 259 CENLLKKFLILNPSKR 274 >5JZN-A nrPDB Length = 280 Score = 108 bits (271), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 80/267 (29%), Positives = 127/267 (47%), Gaps = 17/267 (6%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 ++ R +G G F V C R+T + YA K ++K K R E M NE IL +V Sbjct: 21 YKVGRTIGDGNFAVVKECVERSTAREYALKIIKKS--KCRGKEHMIQNEVSILRRVKHPN 78 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 +V L + L LV+ L+ GGDL I + +A + Y + ++ LH Sbjct: 79 IVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLY--NLASAIKYLHSL 136 Query: 306 RIVYRDLKPENILLDDH----GHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER 361 IV+RD+KPEN+L+ +H +++ D GLA V + GT Y+APE++ Sbjct: 137 NIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVD--GPLYTVCGTPTYVAPEIIAETG 194 Query: 362 YTFSPDWWALGCLLYEMIAGQSPFQQR--KKKIKREEVERLVKEVPEEYSERFSPQARSL 419 Y D WA G + Y ++ G PF+ +++ +++ + P Y + S A+ L Sbjct: 195 YGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKEL 254 Query: 420 CSQLLCKDPAERLGCRGGSAREVKEHP 446 + +L D +R SA +V EHP Sbjct: 255 ITMMLLVDVDQRF-----SAVQVLEHP 276 >4B8L-A nrPDB Length = 286 Score = 108 bits (270), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 78/289 (26%), Positives = 138/289 (47%), Gaps = 17/289 (5%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEK 235 + ++ T + F R LGKG FG V + + + A K L K +++K E E Sbjct: 7 MPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREI 66 Query: 236 QILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEI 295 +I + ++ + + + + L+L G+L + G+ F E R+ + E+ Sbjct: 67 EIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGR--FDEQRSATFMEEL 124 Query: 296 CCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRV--GTVGYMA 353 L H ++++RD+KPEN+L+ G ++I+D G +VH P +++ R GT+ Y+ Sbjct: 125 ADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAP---SLRRRTMCGTLDYLP 181 Query: 354 PEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFS 413 PE+++ + + D W G L YE + G PF E R + V ++ S Sbjct: 182 PEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSP----SHTETHRRIVNVDLKFPPFLS 237 Query: 414 PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLE 462 ++ L S+LL P +RL +G V EHP + K N +R+ G+ + Sbjct: 238 DGSKDLISKLLRYHPPQRLPLKG-----VMEHP-WVKANSRRVLPGVYQ 280 >5TQX-A nrPDB Length = 655 Score = 108 bits (270), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 87/258 (33%), Positives = 128/258 (49%), Gaps = 24/258 (9%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 LG GGFG VC Q R A K + K + +E QI++K+N VV Sbjct: 16 LGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERW--CHEIQIMKKLNHANVVKACD 73 Query: 252 AYE-----TKDALCLVLTLMNGGDLKFHIYHMGQA-GFPEARAVFYAAEICCGLEDLHRE 305 E D L + +GGDL+ + G E++ + ++I G+ LH Sbjct: 74 VPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHEN 133 Query: 306 RIVYRDLKPENILLDDHG----HIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER 361 +I++RDLKPENI+L D G H +I DLG A V +G+ VGT+ Y+APE+ +N+ Sbjct: 134 KIIHRDLKPENIVLQDVGGKIIH-KIIDLGYAKDVDQGELCTEFVGTLQYLAPELFENKP 192 Query: 362 YTFSPDWWALGCLLYEMIAGQSPFQQR------KKKIKREEVERLVKEVPEEYSERFS-- 413 YT + D+W+ G +++E IAG PF +KIK+++ + + RFS Sbjct: 193 YTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSH 252 Query: 414 -PQARSLCSQLLCKDPAE 430 PQ SLCS L +P E Sbjct: 253 LPQPNSLCS--LIVEPME 268 >2OU7-A nrPDB Length = 335 Score = 108 bits (269), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 78/244 (31%), Positives = 124/244 (50%), Gaps = 13/244 (5%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRI-KKRKGEAMALNEKQILEKVNSRFVVSLA 250 LGKGGF + T +++A K + K + K + E M++ E I + + VV Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSM-EISIHRSLAHQHVVGFH 107 Query: 251 YAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYR 310 +E D + +VL L L H + E A +Y +I G + LHR R+++R Sbjct: 108 GFFEDNDFVFVVLELCRRRSLLE--LHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHR 165 Query: 311 DLKPENILLDDHGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKNERYTFSPDWW 369 DLK N+ L++ ++I D GLA V +G+ K GT Y+APEV+ + ++F D W Sbjct: 166 DLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVW 225 Query: 370 ALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYS--ERFSPQARSLCSQLLCKD 427 ++GC++Y ++ G+ PF+ K E R+ K EYS + +P A SL ++L D Sbjct: 226 SIGCIMYTLLVGKPPFETSCLK---ETYLRIKK---NEYSIPKHINPVAASLIQKMLQTD 279 Query: 428 PAER 431 P R Sbjct: 280 PTAR 283 >4J52-A nrPDB Length = 293 Score = 108 bits (269), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 76/244 (31%), Positives = 123/244 (50%), Gaps = 13/244 (5%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRI-KKRKGEAMALNEKQILEKVNSRFVVSLA 250 LGKGGF + T +++A K + K + K + E M++ E I + + VV Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSM-EISIHRSLAHQHVVGFH 80 Query: 251 YAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYR 310 +E D + +VL L L H + E A +Y +I G + LHR R+++R Sbjct: 81 GFFEDNDFVFVVLELCRRRSLL--ELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHR 138 Query: 311 DLKPENILLDDHGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKNERYTFSPDWW 369 DLK N+ L++ ++I D GLA V +G+ K GT Y+APEV+ + ++F D W Sbjct: 139 DLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVW 198 Query: 370 ALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYS--ERFSPQARSLCSQLLCKD 427 ++GC++Y ++ G+ PF+ K E ++ EYS + +P A SL ++L D Sbjct: 199 SIGCIMYTLLVGKPPFETSCLK------ETYLRIKKNEYSIPKHINPVAASLIQKMLQTD 252 Query: 428 PAER 431 P R Sbjct: 253 PTAR 256 >2QNJ-A nrPDB Length = 328 Score = 107 bits (268), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 75/256 (29%), Positives = 131/256 (51%), Gaps = 9/256 (3%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 + QP N +R + +GKG F +V + TG+ A K ++K ++ + + E + Sbjct: 6 DEQPHIGN-YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKL-FREVR 63 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 I++ +N +V L ET+ L L++ +GG++ ++ G+ EAR+ F +I Sbjct: 64 IMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKF--RQIV 121 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 ++ H++RIV+RDLK EN+LLD +I+I+D G + G + G+ Y APE+ Sbjct: 122 SAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPEL 181 Query: 357 VKNERYTF-SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQ 415 + ++Y D W+LG +LY +++G PF + K RE V R +P S Sbjct: 182 FQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIP----FYMSTD 237 Query: 416 ARSLCSQLLCKDPAER 431 +L + L +P +R Sbjct: 238 CENLLKRFLVLNPIKR 253 >2F57-A nrPDB Length = 317 Score = 107 bits (268), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 85/314 (27%), Positives = 143/314 (45%), Gaps = 39/314 (12%) Query: 142 FQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVC 201 FQ ++R++HE A LQ P + + +G+G G VC Sbjct: 19 FQSMSRVSHEQFRAA--------------LQLVVSPGDP--REYLANFIKIGEGSTGIVC 62 Query: 202 ACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCL 261 + TGK A KK++ ++ ++R+ + NE I+ + VV + +Y D L + Sbjct: 63 IATEKHTGKQVAVKKMDLRKQQRRE---LLFNEVVIMRDYHHDNVVDMYSSYLVGDELWV 119 Query: 262 VLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDD 321 V+ + GG L + H E + + L LH + +++RD+K ++ILL Sbjct: 120 VMEFLEGGALTDIVTH---TRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTS 176 Query: 322 HGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA 380 G I++SD G V E K VGT +MAPEV+ Y D W+LG ++ EMI Sbjct: 177 DGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMID 236 Query: 381 GQSPF-----QQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCR 435 G+ P+ Q ++I R+ + VK++ + S R +L ++P++R Sbjct: 237 GEPPYFNEPPLQAMRRI-RDSLPPRVKDL-----HKVSSVLRGFLDLMLVREPSQR---- 286 Query: 436 GGSAREVKEHPLFK 449 +A+E+ HP K Sbjct: 287 -ATAQELLGHPFLK 299 >4APC-A nrPDB Length = 350 Score = 107 bits (267), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 67/241 (27%), Positives = 120/241 (49%), Gaps = 5/241 (2%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 +G+G FG+ + G+ Y K++ R+ ++ E + E +L + +V Sbjct: 32 IGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREE-SRREVAVLANMKHPNIVQYRE 90 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 ++E +L +V+ GGDL I F E + + + +IC L+ +H +I++RD Sbjct: 91 SFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRD 150 Query: 312 LKPENILLDDHGHIRISDLGLA-VHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWA 370 +K +NI L G +++ D G+A V + + +GT Y++PE+ +N+ Y D WA Sbjct: 151 IKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEICENKPYNNKSDIWA 210 Query: 371 LGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAE 430 LGC+LYE+ + F+ K V +++ S +S RSL SQL ++P + Sbjct: 211 LGCVLYELCTLKHAFEAGSMK---NLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNPRD 267 Query: 431 R 431 R Sbjct: 268 R 268 >3DB8-A nrPDB Length = 317 Score = 107 bits (267), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 74/256 (28%), Positives = 124/256 (48%), Gaps = 11/256 (4%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 P T + + R LGKGGF + T +++A K + K + K + E I Sbjct: 37 DPRTMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIH 96 Query: 239 EKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 + +++ VV +E D + +VL + L H + E A ++ + G Sbjct: 97 KSLDNPHVVGFHGFFEDDDFVYVVLEICRRRSLL--ELHKRRKAVTEPEARYFMRQTIQG 154 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVV 357 ++ LH R+++RDLK N+ L+D ++I D GLA + +G+ K GT Y+APEV+ Sbjct: 155 VQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVL 214 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYS--ERFSPQ 415 + ++F D W+LGC+LY ++ G+ PF+ K E ++ EYS +P Sbjct: 215 CKKGHSFEVDIWSLGCILYTLLVGKPPFETSCLK------ETYIRIKKNEYSVPRHINPV 268 Query: 416 ARSLCSQLLCKDPAER 431 A +L ++L DP R Sbjct: 269 ASALIRRMLHADPTLR 284 >2VZ6-A nrPDB Length = 313 Score = 107 bits (266), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 74/268 (27%), Positives = 134/268 (50%), Gaps = 12/268 (4%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 ++ ++ + LGKG F V C G+ YA K + K++ R + + E +I + Sbjct: 21 QSMYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLE-REARICRLLK 79 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 +V L + + L+ L+ GG+L I + + + EA A +I + Sbjct: 80 HPNIVRLHDSISEEGHHYLIFDLVTGGELFEDI--VAREYYSEADASHCIQQILEAVLHC 137 Query: 303 HRERIVYRDLKPENILLDDH---GHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVK 358 H+ +V+RDLKPEN+LL ++++D GLA+ V E Q G GT GY++PEV++ Sbjct: 138 HQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLR 197 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARS 418 + Y D WA G +LY ++ G PF + ++++ + P + +P+A+ Sbjct: 198 KDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 257 Query: 419 LCSQLLCKDPAERLGCRGGSAREVKEHP 446 L +++L +P++R+ +A E +HP Sbjct: 258 LINKMLTINPSKRI-----TAAEALKHP 280 >6C9D-A nrPDB Length = 459 Score = 107 bits (266), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 71/230 (30%), Positives = 121/230 (52%), Gaps = 5/230 (2%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 + QP N +R + +GKG F +V + TG+ A K ++K ++ + + E + Sbjct: 15 DEQPHIGN-YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKL-FREVR 72 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 I++ +N +V L ET+ L LV+ +GG++ ++ G+ EARA F +I Sbjct: 73 IMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKF--RQIV 130 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 ++ H++ IV+RDLK EN+LLD +I+I+D G + G + G+ Y APE+ Sbjct: 131 SAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPEL 190 Query: 357 VKNERYTF-SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVP 405 + ++Y D W+LG +LY +++G PF + K RE V R +P Sbjct: 191 FQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIP 240 >6CMJ-A nrPDB Length = 321 Score = 106 bits (265), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 77/269 (28%), Positives = 128/269 (47%), Gaps = 24/269 (8%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAM--------ALNEKQILEKVNS 243 +GKG +G V YA K L KK++ ++ G + E IL+K++ Sbjct: 42 IGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEIAILKKLDH 101 Query: 244 RFVVSLAYAYE--TKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 VV L + +D L +V L+N G + + E +A FY ++ G+E Sbjct: 102 PNVVKLVEVLDDPNEDHLYMVFELVNQGPV---MEVPTLKPLSEDQARFYFQDLIKGIEY 158 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT-IKGRVGTVGYMAPEVVKNE 360 LH ++I++RD+KP N+L+ + GHI+I+D G++ + VGT +MAPE + Sbjct: 159 LHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSET 218 Query: 361 RYTFSP---DWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 R FS D WA+G LY + GQ PF + +++ E P++ + + Sbjct: 219 RKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQ--PDIAEDLK 276 Query: 418 SLCSQLLCKDPAERLGCRGGSAREVKEHP 446 L +++L K+P R+ E+K HP Sbjct: 277 DLITRMLDKNPESRI-----VVPEIKLHP 300 >4D28-A nrPDB Length = 446 Score = 106 bits (265), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 76/263 (28%), Positives = 129/263 (49%), Gaps = 13/263 (4%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 R +G+G F +V + TG A K + K I K + E I++ V +V L Sbjct: 15 RTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRL 74 Query: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 +K + +VL + GG+L I H G+ E+R F ++ + H + + + Sbjct: 75 YEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYF--QQLVDAVAHCHSKGVYH 132 Query: 310 RDLKPENILLDDHGHIRISDLGLAVHVPEG-QTIKGRVGTVGYMAPEVVKNERYTFS-PD 367 RDLKPEN+LLD +G++++SD GL+ EG + + GT Y+APEV+ + Y S D Sbjct: 133 RDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQGYDGSAAD 192 Query: 368 WWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKD 427 W+ G +L+ ++AG PF + + R + + FS + + L ++L + Sbjct: 193 IWSCGVILFVILAGYLPFSE----TDLPGLYRKINAAEFDCPPWFSAEVKFLIHRILDPN 248 Query: 428 PAERLGCRGGSAREVKEHPLFKK 450 P R+ +G +K+ P F+K Sbjct: 249 PKTRIQIQG-----IKKDPWFRK 266 >4I6B-A nrPDB Length = 308 Score = 106 bits (265), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 67/253 (26%), Positives = 119/253 (47%), Gaps = 7/253 (2%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 P T + + + LGKGGF + K+YA K + R+ K E ++ Sbjct: 24 PTTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHR 83 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 ++ + VV + +E K+ + ++L + + + PE R +Y +I GL Sbjct: 84 ILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVR--YYLRQIVSGL 141 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV-PEGQTIKGRVGTVGYMAPEVVK 358 + LH + I++RDLK N +++ +++ D GLA + P + GT Y++PEV+ Sbjct: 142 KYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLN 201 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARS 418 + + D WALGC++Y M+ G+ PF+ K E R ++E A+ Sbjct: 202 KQGHGAESDIWALGCVMYTMLLGRPPFETTNLK----ETYRSIREARYTMPSSLLAPAKH 257 Query: 419 LCSQLLCKDPAER 431 L + +L K+P +R Sbjct: 258 LIASMLSKNPEDR 270 >5U6Y-A nrPDB Length = 461 Score = 106 bits (264), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 74/265 (27%), Positives = 132/265 (49%), Gaps = 12/265 (4%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 ++ + LGKG F V C G+ YA K + K++ R + + E +I + Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLE-REARICRLLKHPN 60 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 +V L + + L+ L+ GG+L I + + + EA A +I + H+ Sbjct: 61 IVRLHDSISEEGHHYLIFDLVTGGELFEDI--VAREYYSEADASHCIQQILEAVLHCHQM 118 Query: 306 RIVYRDLKPENILLDDH---GHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKNER 361 +V+RDLKPEN+LL ++++D GLA+ V E Q G GT GY++PEV++ + Sbjct: 119 GVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDP 178 Query: 362 YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCS 421 Y D WA G +LY ++ G PF + ++++ + P + +P+A+ L + Sbjct: 179 YGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLIN 238 Query: 422 QLLCKDPAERLGCRGGSAREVKEHP 446 ++L +P++R+ +A E +HP Sbjct: 239 KMLTINPSKRI-----TAAEALKHP 258 >3UTO-A nrPDB Length = 573 Score = 106 bits (264), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 80/297 (26%), Positives = 127/297 (42%), Gaps = 29/297 (9%) Query: 170 FLQWKWLERQPVT---KNTFRQYRV---LGKGGFGEVCACQVRATGKMYACK------KL 217 F WK QPV + Y + LG G FG V RATG +A K + Sbjct: 137 FDIWKQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHES 196 Query: 218 EKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYH 277 +K+ ++K E Q + + +V+L A+E + + ++ M+GG+L F Sbjct: 197 DKETVRK---------EIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGEL-FEKVA 246 Query: 278 MGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDD--HGHIRISDLGLAVH 335 E AV Y ++C GL +H V+ DLKPENI+ +++ D GL H Sbjct: 247 DEHNKMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAH 306 Query: 336 VPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKRE 395 + Q++K GT + APEV + + + D W++G L Y +++G SPF Sbjct: 307 LDPKQSVKVTTGTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLR 366 Query: 396 EVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 V+ + + S + +LL DP R+ + + EHP N Sbjct: 367 NVKSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTRM-----TIHQALEHPWLTPGN 418 >2HAK-A nrPDB Length = 328 Score = 106 bits (264), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 71/230 (30%), Positives = 121/230 (52%), Gaps = 5/230 (2%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 + QP N +R + +GKG F +V + TG+ A K ++K ++ + + E + Sbjct: 9 DEQPHIGN-YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKL-FREVR 66 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 I++ +N +V L ET+ L LV+ +GG++ ++ G+ EARA F +I Sbjct: 67 IMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKF--RQIV 124 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 ++ H++ IV+RDLK EN+LLD +I+I+D G + G + G+ Y APE+ Sbjct: 125 SAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPEL 184 Query: 357 VKNERYTF-SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVP 405 + ++Y D W+LG +LY +++G PF + K RE V R +P Sbjct: 185 FQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIP 234 >4LQP-A nrPDB Length = 508 Score = 105 bits (263), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 56/149 (37%), Positives = 85/149 (57%), Gaps = 2/149 (1%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 F +V+GKG FGEV Q + TGK+YA K L K + K+ A E+ +L +S + Sbjct: 104 FHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSPW 163 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 VVSL Y+++ L L++ + GGDL + + F E FY AE +E +H+ Sbjct: 164 VVSLYYSFQDAQYLYLIMEFLPGGDLMTML--IRWQLFTEDVTRFYMAECILAIETIHKL 221 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLAV 334 ++R +KP+NIL+D GHI++SD GL+ Sbjct: 222 GFIHRAIKPDNILIDIRGHIKLSDFGLST 250 Score = 61.6 bits (148), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 43/132 (32%), Positives = 67/132 (50%), Gaps = 14/132 (10%) Query: 346 VGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPF-----QQRKKKIKREEVERL 400 VGT Y+APE+ + Y DWW+LG ++YE + G PF Q+ +KI E Sbjct: 324 VGTPDYIAPEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQ--- 380 Query: 401 VKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGM 460 + P++ S +A L +LL +RLG GG A E+K HP F+ +++ + Sbjct: 381 TLQFPDDI--HISYEAEDLIRRLLTH-ADQRLGRHGG-ADEIKSHPFFRGVDWNTI--RQ 434 Query: 461 LEPPFKPDPQAI 472 +E P+ P +I Sbjct: 435 VEAPYIPKLSSI 446 >1KOA-A nrPDB Length = 491 Score = 105 bits (263), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 80/297 (26%), Positives = 127/297 (42%), Gaps = 29/297 (9%) Query: 170 FLQWKWLERQPVT---KNTFRQYRV---LGKGGFGEVCACQVRATGKMYACK------KL 217 F WK QPV + Y + LG G FG V RATG +A K + Sbjct: 31 FDIWKQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHES 90 Query: 218 EKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYH 277 +K+ ++K E Q + + +V+L A+E + + ++ M+GG+L F Sbjct: 91 DKETVRK---------EIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGEL-FEKVA 140 Query: 278 MGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDD--HGHIRISDLGLAVH 335 E AV Y ++C GL +H V+ DLKPENI+ +++ D GL H Sbjct: 141 DEHNKMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAH 200 Query: 336 VPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKRE 395 + Q++K GT + APEV + + + D W++G L Y +++G SPF Sbjct: 201 LDPKQSVKVTTGTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLR 260 Query: 396 EVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 V+ + + S + +LL DP R+ + + EHP N Sbjct: 261 NVKSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTRM-----TIHQALEHPWLTPGN 312 >4JXF-A nrPDB Length = 266 Score = 105 bits (262), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 75/266 (28%), Positives = 127/266 (47%), Gaps = 11/266 (4%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 F+ +LGKG F V + TG A K ++KK + K NE +I ++ Sbjct: 9 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPS 68 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 ++ L +E + + LVL + + G++ ++ + + F E A + +I G+ LH Sbjct: 69 ILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKP-FSENEARHFMHQIITGMLYLHSH 127 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRV-GTVGYMAPEVVKNERYTF 364 I++RDL N+LL + +I+I+D GLA + + GT Y++PE+ + Sbjct: 128 GILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGL 187 Query: 365 SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLL 424 D W+LGC+ Y ++ G+ PF K +V E+P S +A+ L QLL Sbjct: 188 ESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMP----SFLSIEAKDLIHQLL 243 Query: 425 CKDPAERLGCRGGSAREVKEHPLFKK 450 ++PA+RL S V +HP + Sbjct: 244 RRNPADRL-----SLSSVLDHPFMSR 264 >3KN6-A nrPDB Length = 325 Score = 105 bits (262), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 75/256 (29%), Positives = 125/256 (48%), Gaps = 18/256 (7%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 LG+G F C + + + +A K + K+ + E AL ++ E + +V L Sbjct: 19 LGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITAL---KLCEGHPN--IVKLHE 73 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 + + LV+ L+NGG+L I + F E A + ++ + +H +V+RD Sbjct: 74 VFHDQLHTFLVMELLNGGELFERI--KKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRD 131 Query: 312 LKPENILL---DDHGHIRISDLGLA-VHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPD 367 LKPEN+L +D+ I+I D G A + P+ Q +K T+ Y APE++ Y S D Sbjct: 132 LKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCD 191 Query: 368 WWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPE-------EYSERFSPQARSLC 420 W+LG +LY M++GQ PFQ + + ++K++ + E + S +A+ L Sbjct: 192 LWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLI 251 Query: 421 SQLLCKDPAERLGCRG 436 LL DP +RL G Sbjct: 252 QGLLTVDPNKRLKMSG 267 >2YCR-A nrPDB Length = 323 Score = 105 bits (261), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 89/291 (30%), Positives = 140/291 (48%), Gaps = 32/291 (10%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRK---GEAM----ALN-- 233 ++ + + LG G GEV R T CKK+ K I KRK G A ALN Sbjct: 9 RDEYIMSKTLGSGACGEVKLAFERKT-----CKKVAIKIISKRKFAIGSAREADPALNVE 63 Query: 234 -EKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYA 292 E +IL+K+N ++ + ++ +D +VL LM GG+L + +G EA Y Sbjct: 64 TEIEILKKLNHPCIIKIKNFFDAEDYY-IVLELMEGGELFDKV--VGNKRLKEATCKLYF 120 Query: 293 AEICCGLEDLHRERIVYRDLKPENILLDDHGH---IRISDLGLAVHVPEGQTIKGRVGTV 349 ++ ++ LH I++RDLKPEN+LL I+I+D G + + E ++ GT Sbjct: 121 YQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTP 180 Query: 350 GYMAPEV---VKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKI--KREEVERLVKEV 404 Y+APEV V Y + D W+LG +L+ ++G PF + + ++ K + + Sbjct: 181 TYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFI 240 Query: 405 PEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKR 455 PE ++E S +A L +LL DP R + E HP + + KR Sbjct: 241 PEVWAE-VSEKALDLVKKLLVVDPKARF-----TTEEALRHPWLQDEDMKR 285 >4CZT-A nrPDB Length = 464 Score = 105 bits (261), Expect = 8e-23, Method: Compositional matrix adjust. Identities = 79/268 (29%), Positives = 132/268 (49%), Gaps = 21/268 (7%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 R LG+G F +V + G A K ++K+++ K K A E ++ + V+ + Sbjct: 17 RTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRM 76 Query: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 +K + VL + GG+L I G+ EAR F ++ ++ H + + Sbjct: 77 FEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYF--QQLINAVDYCHSRGVYH 134 Query: 310 RDLKPENILLDDHGHIRISDLGLAV---HVPEGQTIKGRVGTVGYMAPEVVKNERYTFS- 365 RDLKPEN+LLD +G +++SD GL+ V E + GT Y+APEV+ N+ Y + Sbjct: 135 RDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAK 194 Query: 366 PDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEV-PEEYS--ERFSPQARSLCSQ 422 D W+ G +L+ ++AG PF+ + L K++ E++ FS A+ L + Sbjct: 195 ADLWSCGVILFVLMAGYLPFED-------SNLTSLYKKIFKAEFTCPPWFSASAKKLIKR 247 Query: 423 LLCKDPAERLGCRGGSAREVKEHPLFKK 450 +L +PA R+ + EV E+ FKK Sbjct: 248 ILDPNPATRI-----TFAEVIENEWFKK 270 >5YKS-A nrPDB Length = 377 Score = 105 bits (261), Expect = 8e-23, Method: Compositional matrix adjust. Identities = 69/265 (26%), Positives = 128/265 (48%), Gaps = 13/265 (4%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 + LG+G F V + TG+ A K ++K ++ E + ++ V +V L Sbjct: 41 KTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTL-ATGHLFQEVRCMKLVQHPNIVRL 99 Query: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 +T+ L L+L L +GGD+ F + G E A Y A+I + H+ +V+ Sbjct: 100 YEVIDTQTKLYLILELGDGGDM-FDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVH 158 Query: 310 RDLKPENIL-LDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTF-SPD 367 RDLKPEN++ + G ++++D G + G+ + G++ Y APE++ + Y + D Sbjct: 159 RDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVD 218 Query: 368 WWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKD 427 W+LG +L+ ++ GQ PFQ+ E ++ + S + + L +++L +D Sbjct: 219 IWSLGVILFMLVCGQPPFQEAND----SETLTMIMDCKYTVPSHVSKECKDLITRMLQRD 274 Query: 428 PAERLGCRGGSAREVKEHPLFKKLN 452 P R S E++ HP + ++ Sbjct: 275 PKRR-----ASLEEIENHPWLQGVD 294 >3I6U-A nrPDB Length = 419 Score = 104 bits (260), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 88/291 (30%), Positives = 140/291 (48%), Gaps = 32/291 (10%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRK---GEAM----ALN-- 233 ++ + + LG G GEV R T CKK+ + I KRK G A ALN Sbjct: 134 RDEYIMSKTLGSGACGEVKLAFERKT-----CKKVAIRIISKRKFAIGSAREADPALNVE 188 Query: 234 -EKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYA 292 E +IL+K+N ++ + ++ +D +VL LM GG+L + +G EA Y Sbjct: 189 TEIEILKKLNHPCIIKIKNFFDAEDYY-IVLELMEGGELFDKV--VGNKRLKEATCKLYF 245 Query: 293 AEICCGLEDLHRERIVYRDLKPENILLDDHGH---IRISDLGLAVHVPEGQTIKGRVGTV 349 ++ ++ LH I++RDLKPEN+LL I+I+D G + + E ++ GT Sbjct: 246 YQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTP 305 Query: 350 GYMAPEV---VKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKI--KREEVERLVKEV 404 Y+APEV V Y + D W+LG +L+ ++G PF + + ++ K + + Sbjct: 306 TYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFI 365 Query: 405 PEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKR 455 PE ++E S +A L +LL DP R + E HP + + KR Sbjct: 366 PEVWAE-VSEKALDLVKKLLVVDPKARF-----TTEEALRHPWLQDEDMKR 410 >4CQG-A nrPDB Length = 331 Score = 103 bits (258), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 79/266 (29%), Positives = 130/266 (48%), Gaps = 20/266 (7%) Query: 186 FRQYRVLGKGGFGEV-CACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 + Y +G GGF +V AC V TG+M A K ++K + E L+ + + Sbjct: 11 YELYETIGTGGFAKVKLACHV-LTGEMVAIKIMDKNALGSDLPRVKT--EIDALKSLRHQ 67 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 + L + ETK+ + +VL GG+L +I + E R VF +I + +H Sbjct: 68 HICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVF--RQILSAVAYVHS 125 Query: 305 ERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT---IKGRVGTVGYMAPEVVKNER 361 + +RDLKPEN+L D++ +++ D GL P+G ++ G++ Y APE+++ + Sbjct: 126 QGYAHRDLKPENLLFDENHKLKLIDFGLCAK-PKGNKDYHLQECCGSLAYAAPELIQGKS 184 Query: 362 YTFS-PDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC 420 Y S D W++G LLY ++ G PF +++ R EVP + SP + L Sbjct: 185 YLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVP----KWLSPSSILLL 240 Query: 421 SQLLCKDPAERLGCRGGSAREVKEHP 446 Q+L DP +R+ S R + HP Sbjct: 241 QQMLQVDPKKRI-----SMRNLLNHP 261 >4NIF-A nrPDB Length = 333 Score = 103 bits (257), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 83/264 (31%), Positives = 127/264 (48%), Gaps = 21/264 (7%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLA 250 +G G + E C +AT YA K ++K K+ E + + +L +++L Sbjct: 15 TIGVGSYSECKRCVHKATNMEYAVKVIDKS--KRDPSEEIEI----LLRYGQHPNIITLK 68 Query: 251 YAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYR 310 Y+ + LV LM GG+L I + Q F E A F I +E LH + +V+R Sbjct: 69 DVYDDGKHVYLVTELMRGGELLDKI--LRQKFFSEREASFVLHTIGKTVEYLHSQGVVHR 126 Query: 311 DLKPENIL-LDDHGH---IRISDLGLAVHV-PEGQTIKGRVGTVGYMAPEVVKNERYTFS 365 DLKP NIL +D+ G+ +RI D G A + E + T ++APEV+K + Y Sbjct: 127 DLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEG 186 Query: 366 PDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVK---EVPEEYSERFSPQARSLCSQ 422 D W+LG LLY M+AG +PF E + R+ + S A+ L S+ Sbjct: 187 CDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSK 246 Query: 423 LLCKDPAERLGCRGGSAREVKEHP 446 +L DP +RL +A++V +HP Sbjct: 247 MLHVDPHQRL-----TAKQVLQHP 265 >4KS7-A nrPDB Length = 292 Score = 103 bits (256), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 69/266 (25%), Positives = 127/266 (47%), Gaps = 23/266 (8%) Query: 189 YRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVS 248 Y +G+G G VC + + +G+ A K ++ ++ ++R+ + NE I+ VV Sbjct: 28 YVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRE---LLFNEVVIMRDYQHFNVVE 84 Query: 249 LAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIV 308 + +Y + L +++ + GG L + Q E + + L LH + ++ Sbjct: 85 MYKSYLVGEELWVLMEFLQGGALTDIV---SQVRLNEEQIATVCEAVLQALAYLHAQGVI 141 Query: 309 YRDLKPENILLDDHGHIRISDLGLAVHVPEGQ-TIKGRVGTVGYMAPEVVKNERYTFSPD 367 +RD+K ++ILL G +++SD G + + K VGT +MAPEV+ Y D Sbjct: 142 HRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVD 201 Query: 368 WWALGCLLYEMIAGQSPF-----QQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQ 422 W+LG ++ EM+ G+ P+ Q K+++ +L + S + SP R + Sbjct: 202 IWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKL------KNSHKVSPVLRDFLER 255 Query: 423 LLCKDPAERLGCRGGSAREVKEHPLF 448 +L +DP ER +A+E+ +HP Sbjct: 256 MLVRDPQER-----ATAQELLDHPFL 276 >3SOA-A nrPDB Length = 444 Score = 102 bits (255), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 72/265 (27%), Positives = 131/265 (49%), Gaps = 12/265 (4%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 ++ + LGKG F V C G+ YA + K++ R + + E +I + Sbjct: 13 YQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLE-REARICRLLKHPN 71 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 +V L + + L+ L+ GG+L I + + + EA A +I + H+ Sbjct: 72 IVRLHDSISEEGHHYLIFDLVTGGELFEDI--VAREYYSEADASHCIQQILEAVLHCHQM 129 Query: 306 RIVYRDLKPENILLDDH---GHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKNER 361 +V+R+LKPEN+LL ++++D GLA+ V E Q G GT GY++PEV++ + Sbjct: 130 GVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDP 189 Query: 362 YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCS 421 Y D WA G +LY ++ G PF + ++++ + P + +P+A+ L + Sbjct: 190 YGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLIN 249 Query: 422 QLLCKDPAERLGCRGGSAREVKEHP 446 ++L +P++R+ +A E +HP Sbjct: 250 KMLTINPSKRI-----TAAEALKHP 269 >4YNZ-A nrPDB Length = 342 Score = 102 bits (255), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 84/285 (29%), Positives = 130/285 (45%), Gaps = 25/285 (8%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMAL----NEKQILEKV 241 +R + LGKG G V+ C+K+ K + + K L E IL+ + Sbjct: 12 YRLEKTLGKGQTG-----LVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLI 66 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 V+ L YE K L LVL ++GG+L ++ G+ EAR F +I L+ Sbjct: 67 EHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFF--RQIISALDF 124 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER 361 H I +RDLKPEN+LLD+ +IRI+D G+A ++ G+ Y PEV++ E+ Sbjct: 125 CHSHSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEK 184 Query: 362 YTF-SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC 420 Y D W+ G +L+ ++ G PF + E+V+R V +P P +SL Sbjct: 185 YDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMP----HFIPPDCQSLL 240 Query: 421 SQLLCKDPAERLGCR---------GGSAREVKEHPLFKKLNFKRL 456 ++ D A RL GG E P+ +K+ + L Sbjct: 241 RGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSL 285 >6FDY-U nrPDB Length = 276 Score = 102 bits (253), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 76/246 (30%), Positives = 118/246 (47%), Gaps = 9/246 (3%) Query: 192 LGKGGFGEVC-ACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLA 250 LG G + V A + T ++ A K + KK + K E + L E +IL+ + +V L Sbjct: 19 LGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENL-LTEIEILKGIRHPHIVQLK 77 Query: 251 YAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYR 310 D + L++ GGDL I+ + PE A + ++ L+ LH I + Sbjct: 78 DFQWDSDNIYLIMEFCAGGDLSRFIH--TRRILPEKVARVFMQQLASALQFLHERNISHL 135 Query: 311 DLKPENILLD--DHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDW 368 DLKP+NILL + H++++D G A H+ G+ YMAPE+V +Y D Sbjct: 136 DLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQYDARVDL 195 Query: 369 WALGCLLYEMIAGQSPFQQRKKKIKREEV-ERLVKEVPEEYSERFSPQARSLCSQLLCKD 427 W++G +LYE + GQ PF R E++ V E+P S R L +LL +D Sbjct: 196 WSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELP--LRPLLSRDCRDLLQRLLERD 253 Query: 428 PAERLG 433 P+ R+ Sbjct: 254 PSRRIS 259 >3IS5-A nrPDB Length = 285 Score = 102 bits (253), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 85/282 (30%), Positives = 128/282 (45%), Gaps = 24/282 (8%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 Q + F R LG G FG+V + R++G K + K R + + A E ++L Sbjct: 17 QGTIDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEA--EIEVL 74 Query: 239 EKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC-- 296 + ++ ++ + +E + +V+ GG+L I G +A + Y AE+ Sbjct: 75 KSLDHPNIIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARG--KALSEGYVAELMKQ 132 Query: 297 --CGLEDLHRERIVYRDLKPENILLDD---HGHIRISDLGLAVHVPEGQTIKGRVGTVGY 351 L H + +V++DLKPENIL D H I+I D GLA + GT Y Sbjct: 133 MMNALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALY 192 Query: 352 MAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSER 411 MAPEV K + TF D W+ G ++Y ++ G PF EEV++ Y+ Sbjct: 193 MAPEVFKRD-VTFKCDIWSAGVVMYFLLTGCLPF----TGTSLEEVQQKATYKEPNYAVE 247 Query: 412 ---FSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 +PQA L Q+L KDP R SA +V H FK+ Sbjct: 248 CRPLTPQAVDLLKQMLTKDPERR-----PSAAQVLHHEWFKQ 284 >4KIK-B nrPDB Length = 677 Score = 101 bits (252), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 75/230 (32%), Positives = 112/230 (48%), Gaps = 21/230 (9%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 LG GGFG V + TG+ A K+ ++ + R E L E QI+ ++ VV+ Sbjct: 27 LGTGGFGNVIRWHNQETGEQIAIKQC-RQELSPRNRERWCL-EIQIMRRLTHPNVVAARD 84 Query: 252 AYETKDALC------LVLTLMNGGDLKFHIYHMGQA-GFPEARAVFYAAEICCGLEDLHR 304 E L L + GGDL+ ++ G E + ++I L LH Sbjct: 85 VPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHE 144 Query: 305 ERIVYRDLKPENILLDDHGHIR----ISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE 360 RI++RDLKPENI+L G R I DLG A + +G VGT+ Y+APE+++ + Sbjct: 145 NRIIHRDLKPENIVLQ-QGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQ 203 Query: 361 RYTFSPDWWALGCLLYEMIAGQSPF-------QQRKKKIKREEVERLVKE 403 +YT + D+W+ G L +E I G PF Q K ++ EV+ +V E Sbjct: 204 KYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSE 253 >2BPM-A nrPDB Length = 309 Score = 101 bits (252), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 84/300 (28%), Positives = 141/300 (47%), Gaps = 36/300 (12%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 V F++ +G+G +G V + + TG++ A KK+ + + + A+ E +L++ Sbjct: 4 VDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKI-RLDTETEGVPSTAIREISLLKE 62 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 +N +V L T++ L LV ++ DLK + G P Y ++ GL Sbjct: 63 LNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLA 121 Query: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGL--AVHVPEGQTIKGRVGTVGYMAPEVVK 358 H R+++RDLKP+N+L++ G I+++D GL A VP +T V T+ Y APE++ Sbjct: 122 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPV-RTYTHEVVTLWYRAPEILL 180 Query: 359 N-ERYTFSPDWWALGCLLYEMIA------GQSPFQQ-----RKKKIKREEVERLVKEVPE 406 + Y+ + D W+LGC+ EM+ G S Q R E V V +P+ Sbjct: 181 GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 240 Query: 407 -----------EYSERFSP---QARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 ++S+ P RSL SQ+L DP +R+ + A HP F+ + Sbjct: 241 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALA-----HPFFQDVT 295 >3Q5I-A nrPDB Length = 504 Score = 101 bits (251), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 75/262 (28%), Positives = 127/262 (48%), Gaps = 20/262 (7%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKK----------RKGEAMALNE 234 ++ + R LG G +GEV C+ + A K ++K + K K NE Sbjct: 37 SYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYNE 96 Query: 235 KQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAE 294 +L+ ++ ++ L +E K LV GG+L I + + F E A + Sbjct: 97 ISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQI--INRHKFDECDAANIMKQ 154 Query: 295 ICCGLEDLHRERIVYRDLKPENILLDDHG---HIRISDLGLAVHVPEGQTIKGRVGTVGY 351 I G+ LH+ IV+RD+KPENILL++ +I+I D GL+ + ++ R+GT Y Sbjct: 155 ILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTAYY 214 Query: 352 MAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPF--QQRKKKIKREEVERLVKEVPEEYS 409 +APEV+K ++Y D W+ G ++Y ++ G PF Q + IK+ E + + + Sbjct: 215 IAPEVLK-KKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKGKYYFDFND--W 271 Query: 410 ERFSPQARSLCSQLLCKDPAER 431 + S +A+ L +L D +R Sbjct: 272 KNISDEAKELIKLMLTYDYNKR 293 >4WNO-A nrPDB Length = 287 Score = 101 bits (251), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 69/244 (28%), Positives = 121/244 (49%), Gaps = 17/244 (6%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKM-YACKKLEKKRIKKRKGEAMALNEKQI 237 + V K F + ++G G F V + RA + A K + KK + K + + E +I Sbjct: 13 ETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAK--SQTLLGKEIKI 70 Query: 238 LEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 L+++ +V+L E +++ LV+ NGGDL +++ M E + +I Sbjct: 71 LKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRT--LSEDTIRLFLQQIAG 128 Query: 298 GLEDLHRERIVYRDLKPENILLDDHG---------HIRISDLGLAVHVPEGQTIKGRVGT 348 + LH + I++RDLKP+NILL + ++I+D G A ++ G+ Sbjct: 129 AMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGS 188 Query: 349 VGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKR---EEVERLVKEVP 405 YMAPEV+ ++ Y D W++G ++Y+ + G++PFQ + R E+ + LV +P Sbjct: 189 PMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIP 248 Query: 406 EEYS 409 E S Sbjct: 249 RETS 252 >3LM0-A nrPDB Length = 327 Score = 101 bits (251), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 71/244 (29%), Positives = 116/244 (47%), Gaps = 5/244 (2%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS-RFVVSLA 250 LG+G F V C ++TG+ YA K L+K+R + + A L+E +LE S V++L Sbjct: 37 LGRGKFAVVRQCISKSTGQEYAAKFLKKRR-RGQDCRAEILHEIAVLELAKSCPRVINLH 95 Query: 251 YAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYR 310 YE + L+L GG++ E + +I G+ LH+ IV+ Sbjct: 96 EVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHL 155 Query: 311 DLKPENILLDD---HGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPD 367 DLKP+NILL G I+I D G++ + ++ +GT Y+APE++ + T + D Sbjct: 156 DLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPITTATD 215 Query: 368 WWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKD 427 W +G + Y ++ SPF + + ++ + EE S A LL K+ Sbjct: 216 MWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKN 275 Query: 428 PAER 431 P +R Sbjct: 276 PEKR 279 >5YV8-A nrPDB Length = 298 Score = 100 bits (248), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 79/295 (26%), Positives = 130/295 (44%), Gaps = 39/295 (13%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAM---------- 230 V N + +GKG +G V YA K L KK++ ++ G Sbjct: 10 VQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPA 69 Query: 231 -------------ALNEKQILEKVNSRFVVSLAYAYE--TKDALCLVLTLMNGGDLKFHI 275 E IL+K++ VV L + +D L +V L+N G + + Sbjct: 70 PGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPV---M 126 Query: 276 YHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVH 335 E +A FY ++ G+E LH ++I++RD+KP N+L+ + GHI+I+D G++ Sbjct: 127 EVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNE 186 Query: 336 VPEGQT-IKGRVGTVGYMAPEVVKNERYTFSP---DWWALGCLLYEMIAGQSPFQQRKKK 391 + VGT +MAPE + R FS D WA+G LY + GQ PF + Sbjct: 187 FKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIM 246 Query: 392 IKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHP 446 +++ E P++ + + L +++L K+P R+ E+K HP Sbjct: 247 CLHSKIKSQALEFPDQ--PDIAEDLKDLITRMLDKNPESRI-----VVPEIKLHP 294 >3QA8-A nrPDB Length = 676 Score = 99.0 bits (245), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 71/207 (34%), Positives = 105/207 (50%), Gaps = 18/207 (8%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 LG GGFG V + TG+ A K+ ++ + + E L E QI++K+N VVS Sbjct: 22 LGTGGFGYVLRWIHQDTGEQVAIKQC-RQELSPKNRERWCL-EIQIMKKLNHPNVVS--- 76 Query: 252 AYETKDAL---------CLVLTLMNGGDLKFHIYHMGQA-GFPEARAVFYAAEICCGLED 301 A E D L L + GGDL+ ++ G E ++I L Sbjct: 77 AREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSALRY 136 Query: 302 LHRERIVYRDLKPENILLDDHGH---IRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVK 358 LH RI++RDLKPENI+L +I DLG A + +G+ VGT+ Y+APE+++ Sbjct: 137 LHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPELLE 196 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPF 385 ++YT + D+W+ G L +E I G PF Sbjct: 197 QKKYTVTVDYWSFGTLAFECITGFRPF 223 >4D2V-A nrPDB Length = 356 Score = 98.6 bits (244), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 74/266 (27%), Positives = 128/266 (48%), Gaps = 20/266 (7%) Query: 186 FRQYRVLGKGGFGEV-CACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 + + +G GGF +V AC + TG+M A K ++K + E + L+ + + Sbjct: 31 YELHETIGTGGFAKVKLACHI-LTGEMVAIKIMDKNTLGSDLPRIK--TEIEALKNLRHQ 87 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 + L + ET + + +VL GG+L +I + E R VF +I + +H Sbjct: 88 HICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVF--RQIVSAVAYVHS 145 Query: 305 ERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT---IKGRVGTVGYMAPEVVKNER 361 + +RDLKPEN+L D++ +++ D GL P+G ++ G + Y APE+++ + Sbjct: 146 QGYAHRDLKPENLLFDEYHKLKLIDFGLCAK-PKGNKDYHLQACCGALAYAAPELIQGKS 204 Query: 362 YTFS-PDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC 420 Y S D W++G LLY ++ G PF ++ R +VP + SP + L Sbjct: 205 YLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVP----KWLSPSSILLL 260 Query: 421 SQLLCKDPAERLGCRGGSAREVKEHP 446 Q+L DP +R+ S + + HP Sbjct: 261 QQMLQVDPKKRI-----SMKNLLNHP 281 >1CM8-A nrPDB Length = 367 Score = 97.8 bits (242), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 91/319 (28%), Positives = 141/319 (44%), Gaps = 60/319 (18%) Query: 178 RQPVTKN------TFRQYRVLGKGGFGEVCACQVRATGKMYACKKL----EKKRIKKRKG 227 RQ VTK +R + +G G +G VC+ TG A KKL + + KR Sbjct: 13 RQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR-- 70 Query: 228 EAMALNEKQILEKVNSRFVVSLAYAY---ETKDALC---LVLTLMNGGDLKFHIYHMGQA 281 A E ++L+ + V+ L + ET D LV+ M G DL + H Sbjct: 71 ---AYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH---E 123 Query: 282 GFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT 341 E R F ++ GL +H I++RDLKP N+ +++ ++I D GLA T Sbjct: 124 KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMT 183 Query: 342 IKGRVGTVGYMAPEVVKN-ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERL 400 G V T Y APEV+ N RYT + D W++GC++ EMI G++ F+ + +E+ ++ Sbjct: 184 --GYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKV 241 Query: 401 VKEVPEEYSERF---------------------------SPQARSLCSQLLCKDPAERLG 433 P E+ +R SP A +L ++L D +R+ Sbjct: 242 TGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV- 300 Query: 434 CRGGSAREVKEHPLFKKLN 452 +A E HP F+ L+ Sbjct: 301 ----TAGEALAHPYFESLH 315 >6FD3-A nrPDB Length = 300 Score = 97.4 bits (241), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 73/269 (27%), Positives = 125/269 (46%), Gaps = 15/269 (5%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 K + ++ +G+G G V ATG+ A K++ ++ K++ + +NE ++ + Sbjct: 21 KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE---LIINEILVMRENK 77 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 + +V+ +Y D L +V+ + GG L + + E + E L+ L Sbjct: 78 NPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALDFL 134 Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAVHV-PEGQTIKGRVGTVGYMAPEVVKNER 361 H ++++RD+K +NILL G ++++D G + PE VGT +MAPEVV + Sbjct: 135 HSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA 194 Query: 362 YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPE-EYSERFSPQARSLC 420 Y D W+LG + EM+ G+ P+ R PE + ER S R Sbjct: 195 YGPKVDIWSLGIMAIEMVEGEPPYLNENP--LRALYLIATNGTPELQNPERLSAVFRDFL 252 Query: 421 SQLLCKDPAERLGCRGGSAREVKEHPLFK 449 ++ L D R GSA+E+ +HP K Sbjct: 253 NRCLEMDVDRR-----GSAKELLQHPFLK 276 >4MVF-A nrPDB Length = 506 Score = 95.9 bits (237), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 77/267 (28%), Positives = 128/267 (47%), Gaps = 22/267 (8%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 LG+G +G V + T ++YA K+ +K R+K E +I++K++ +V L Sbjct: 65 LGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNIN---RFFQEIEIMKKLDHPNIVKLYE 121 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 YE + + L++ L +G +L I G F E A +I + LH IV+RD Sbjct: 122 TYENDNYIYLIMELCSGRELFDSIIENG--SFTEKNAATIMKQIFSAIFYLHSLNIVHRD 179 Query: 312 LKPENILLDDHGH---IRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDW 368 LKPEN L ++I D GL+ ++ G+ + GT Y+AP+V+ + +Y D Sbjct: 180 LKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVL-DGKYDKKCDI 238 Query: 369 WALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSER----FSPQARSLCSQLL 424 W+ G ++Y ++ G PF EV + VK+ + E S A++L ++LL Sbjct: 239 WSSGVIMYTLLCGYPPFYGDTDN----EVLKKVKKGEFCFYENDWGSISSDAKNLITKLL 294 Query: 425 CKDPAERLGCRGGSAREVKEHPLFKKL 451 +P ER C + E HP ++ Sbjct: 295 TYNPNER--C---TIEEALNHPWITQM 316 >4AF3-A nrPDB Length = 292 Score = 95.9 bits (237), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 74/258 (28%), Positives = 123/258 (47%), Gaps = 7/258 (2%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 T + F R LGKG FG V + + + + A K L K +I+K E E +I + Sbjct: 21 TIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHL 80 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 + ++ L + + + L+L G+L + F E R E+ L Sbjct: 81 HHPNILRLYNYFYDRRRIYLILEYAPRGELYKEL--QKSCTFDEQRTATIMEELADALMY 138 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER 361 H +++++RD+KPEN+LL G ++I+D G +VH P + K GT+ Y+ PE+++ Sbjct: 139 CHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRR-KTMCGTLDYLPPEMIEGRM 197 Query: 362 YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCS 421 + D W +G L YE++ G PF+ E R + +V ++ A+ L S Sbjct: 198 HNEKVDLWCIGVLCYELLVGNPPFES----ASHNETYRRIVKVDLKFPASVPTGAQDLIS 253 Query: 422 QLLCKDPAERLGCRGGSA 439 +LL +P+ERL SA Sbjct: 254 KLLRHNPSERLPLAQVSA 271 >3F3Z-A nrPDB Length = 277 Score = 95.5 bits (236), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 76/276 (27%), Positives = 129/276 (46%), Gaps = 18/276 (6%) Query: 182 TKNTFRQYRVL----GKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQI 237 TK QY L G+G +GEV + T A KK+ K ++ E +I Sbjct: 3 TKGDINQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDRFK---QEIEI 59 Query: 238 LEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 ++ ++ ++ L +E + LV+ L GG+L + H + F E+ A ++ Sbjct: 60 MKSLDHPNIIRLYETFEDNTDIYLVMELCTGGELFERVVH--KRVFRESDAARIMKDVLS 117 Query: 298 GLEDLHRERIVYRDLKPENIL-LDDH--GHIRISDLGLAVHVPEGQTIKGRVGTVGYMAP 354 + H+ + +RDLKPEN L L D +++ D GLA G+ ++ +VGT Y++P Sbjct: 118 AVAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSP 177 Query: 355 EVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSP 414 +V++ Y D W+ G ++Y ++ G PF ++ PE+ SP Sbjct: 178 QVLEG-LYGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWLNVSP 236 Query: 415 QARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 QA SL +LL K P +R+ ++ + EH F+K Sbjct: 237 QAESLIRRLLTKSPKQRI-----TSLQALEHEWFEK 267 >5WAX-A nrPDB Length = 310 Score = 94.4 bits (233), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 77/271 (28%), Positives = 130/271 (47%), Gaps = 26/271 (9%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALN-EKQILEKVNSRF--V 246 R +G G FG + RA G++ A K +E+ GE + N +++I+ + R + Sbjct: 17 RDIGSGNFGVARLMRNRADGQLVAVKYIER-------GEKIDENVQREIINHRSLRHPNI 69 Query: 247 VSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRER 306 + T L +V+ +GG+L I + G+ F E A F+ ++ G+ H + Sbjct: 70 IRFKEVILTPTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSYCHSMQ 127 Query: 307 IVYRDLKPENILLDDHG--HIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTF 364 + +RDLK EN LLD ++I D G + K VGT Y+APEV+ + Y Sbjct: 128 VCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 187 Query: 365 S-PDWWALGCLLYEMIAGQSPFQQ-RKKKIKREEVERLVK---EVPEEYSERFSPQARSL 419 D W+ G LY M+ G PF+ + K R+ ++R++ +P+ SP+ + L Sbjct: 188 KVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYV--HISPECQDL 245 Query: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 S++ +PA R+ + E++ HP F K Sbjct: 246 ISRIFVANPATRI-----TIPEIRNHPWFLK 271 >2W4O-A nrPDB Length = 349 Score = 94.4 bits (233), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 73/245 (29%), Positives = 115/245 (46%), Gaps = 11/245 (4%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 LG+G V C+ + T K YA K L+K KK + E +L +++ ++ L Sbjct: 61 LGRGATSIVYRCKQKGTQKPYALKVLKKTVDKK-----IVRTEIGVLLRLSHPNIIKLKE 115 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 +ET + LVL L+ GG+L I G + E A +I + LH IV+RD Sbjct: 116 IFETPTEISLVLELVTGGELFDRIVEKGY--YSERDAADAVKQILEAVAYLHENGIVHRD 173 Query: 312 LKPENILLDD---HGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDW 368 LKPEN+L ++I+D GL+ V +K GT GY APE+++ Y D Sbjct: 174 LKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDM 233 Query: 369 WALGCLLYEMIAGQSPF-QQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKD 427 W++G + Y ++ G PF +R + + + + S A+ L +L+ D Sbjct: 234 WSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLD 293 Query: 428 PAERL 432 P +RL Sbjct: 294 PKKRL 298 >6QAU-A nrPDB Length = 280 Score = 94.4 bits (233), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 66/232 (28%), Positives = 111/232 (47%), Gaps = 17/232 (7%) Query: 191 VLGKGGFGEVCACQVR-ATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 ++G G F V + R T A K + KK + K + + E +IL+++ +V+L Sbjct: 18 LVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSK--SQILLGKEIKILKELQHENIVAL 75 Query: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 E +++ LV+ NGGDL ++ G R + +I + LH + I++ Sbjct: 76 YDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLH--QIAAAMRILHSKGIIH 133 Query: 310 RDLKPENILLDDHGH---------IRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE 360 RDLKP+NILL I+I+D G A ++ G+ YMAPEV+ ++ Sbjct: 134 RDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYMAPEVIMSQ 193 Query: 361 RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKR---EEVERLVKEVPEEYS 409 Y D W++G ++Y+ + G+ PFQ + R E+ L+ +P E S Sbjct: 194 HYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETS 245 >6CCF-A nrPDB Length = 290 Score = 94.4 bits (233), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 75/229 (32%), Positives = 113/229 (49%), Gaps = 28/229 (12%) Query: 234 EKQILEKVNSRFVVSLAYAYE--TKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFY 291 E IL+K++ VV L + +D L LV L+ G + + F E +A Y Sbjct: 78 EIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPV---MEVPCDKPFSEEQARLY 134 Query: 292 AAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT--IKGRVGTV 349 ++ GLE LH ++IV+RD+KP N+LL D GH++I+D G++ EG + GT Sbjct: 135 LRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF-EGNDAQLSSTAGTP 193 Query: 350 GYMAPEVVKNERYTFSP---DWWALGCLLYEMIAGQSPFQQR-----KKKIKREEVERLV 401 +MAPE + + +FS D WA G LY + G+ PF +KIK E V + Sbjct: 194 AFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPV--VF 251 Query: 402 KEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 E PE S + + L ++L K+P R+G ++K HP K Sbjct: 252 PEEPE-----ISEELKDLILKMLDKNPETRIGV-----PDIKLHPWVTK 290 >3NIZ-A nrPDB Length = 311 Score = 94.4 bits (233), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 75/296 (25%), Positives = 148/296 (50%), Gaps = 39/296 (13%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 +++ +G+G +G V + + G++ A K++ + + + A+ E +L++++ Sbjct: 23 YQKLEKVGEGTYGVVYKAK-DSQGRIVALKRI-RLDAEDEGIPSTAIREISLLKELHHPN 80 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 +VSL ++ L LV M DLK + + G +++ Y ++ G+ H+ Sbjct: 81 IVSLIDVIHSERCLTLVFEFMEK-DLK-KVLDENKTGLQDSQIKIYLYQLLRGVAHCHQH 138 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGL--AVHVPEGQTIKGRVGTVGYMAPEVVK-NERY 362 RI++RDLKP+N+L++ G ++++D GL A +P ++ V T+ Y AP+V+ +++Y Sbjct: 139 RILHRDLKPQNLLINSDGALKLADFGLARAFGIPV-RSYTHEVVTLWYRAPDVLMGSKKY 197 Query: 363 TFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERL-----------VKEVP------ 405 + S D W++GC+ EMI G+ F + ++ + V+E+P Sbjct: 198 STSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWKQRT 257 Query: 406 -EEYSER--------FSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 + + ++ F + L S +LC DP +R+ SAR+ HP FK L+ Sbjct: 258 FQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRI-----SARDAMNHPYFKDLD 308 >5DBX-A nrPDB Length = 328 Score = 94.4 bits (233), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 79/277 (28%), Positives = 129/277 (46%), Gaps = 33/277 (11%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 P+ ++ + V+G G V A + + A K++ ++ + E L E Q + Sbjct: 7 PICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDEL--LKEIQAMS 64 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGG---DLKFHIYHMGQ---AGFPEARAVFYAA 293 + + VV+ ++ KD L LV+ L++GG D+ +I + G+ EA Sbjct: 65 QCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILK 124 Query: 294 EICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI------KGRVG 347 E+ GL+ LHR ++RDLK NILL + G ++I+D G++ + G + K VG Sbjct: 125 EVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVG 184 Query: 348 TVGYMAPEVVKNER-YTFSPDWWALGCLLYEMIAGQSPFQ------------QRKKKIKR 394 T +MAPEV++ R Y F D W+ G E+ G +P+ Q Sbjct: 185 TPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLE 244 Query: 395 EEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 VE KE+ ++Y + F R L S L KDP++R Sbjct: 245 TGVED--KEMMKKYGKSF----RKLLSLCLQKDPSKR 275 >3Q53-A nrPDB Length = 306 Score = 94.4 bits (233), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 72/269 (26%), Positives = 125/269 (46%), Gaps = 15/269 (5%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 K + ++ +G+G G V ATG+ A +++ ++ K++ + +NE ++ + Sbjct: 20 KKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKE---LIINEILVMRENK 76 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 + +V+ +Y D L +V+ + GG L + + E + E LE L Sbjct: 77 NPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALEFL 133 Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAVHV-PEGQTIKGRVGTVGYMAPEVVKNER 361 H ++++RD+K +NILL G ++++D G + PE VGT +MAPEVV + Sbjct: 134 HSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA 193 Query: 362 YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPE-EYSERFSPQARSLC 420 Y D W+LG + EMI G+ P+ R PE + E+ S R Sbjct: 194 YGPKVDIWSLGIMAIEMIEGEPPYLNENP--LRALYLIATNGTPELQNPEKLSAIFRDFL 251 Query: 421 SQLLCKDPAERLGCRGGSAREVKEHPLFK 449 ++ L D +R GSA+E+ +H K Sbjct: 252 NRCLEMDVEKR-----GSAKELIQHQFLK 275 >3UC3-A nrPDB Length = 361 Score = 93.6 bits (231), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 81/290 (27%), Positives = 131/290 (45%), Gaps = 36/290 (12%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF-----V 246 +G G FG + + T ++ A K +E+ A++E E +N R + Sbjct: 28 IGSGNFGVARLMRDKLTKELVAVKYIER---------GAAIDENVQREIINHRSLRHPNI 78 Query: 247 VSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRER 306 V T L +++ +GG+L I + G+ F E A F+ ++ G+ H + Sbjct: 79 VRFKEVILTPTHLAIIMEYASGGELYERICNAGR--FSEDEARFFFQQLLSGVSYCHSMQ 136 Query: 307 IVYRDLKPENILLDDH--GHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTF 364 I +RDLK EN LLD ++I D G + K VGT Y+APEV+ + Y Sbjct: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 Query: 365 S-PDWWALGCLLYEMIAGQSPFQQ-RKKKIKREEVERLVK---EVPEEYSERFSPQARSL 419 D W+ G LY M+ G PF+ + + R+ ++R++ +P++ R SP+ L Sbjct: 197 KIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI--RISPECCHL 254 Query: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLFKK------LNFKRLGAGMLEP 463 S++ DPA R+ S E+K H F K +N G+ EP Sbjct: 255 ISRIFVADPATRI-----SIPEIKTHSWFLKNLPADLMNESNTGSQFQEP 299 >4JG6-A nrPDB Length = 355 Score = 93.2 bits (230), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 79/263 (30%), Positives = 123/263 (46%), Gaps = 21/263 (7%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 +G G + C +AT +A K ++K K+ E + + +L +++L Sbjct: 43 IGVGSYSVCKRCIHKATNMEFAVKIIDKS--KRDPTEEIEI----LLRYGQHPNIITLKD 96 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 Y+ + +V LM GG+L I EA AV + I +E LH + +V+RD Sbjct: 97 VYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFT--ITKTVEYLHAQGVVHRD 154 Query: 312 LKPENIL-LDDHGH---IRISDLGLAVHV-PEGQTIKGRVGTVGYMAPEVVKNERYTFSP 366 LKP NIL +D+ G+ IRI D G A + E + T ++APEV++ + Y + Sbjct: 155 LKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLERQGYDAAC 214 Query: 367 DWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVK---EVPEEYSERFSPQARSLCSQL 423 D W+LG LLY M+ G +PF E + R+ + Y S A+ L S++ Sbjct: 215 DIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKM 274 Query: 424 LCKDPAERLGCRGGSAREVKEHP 446 L DP +RL +A V HP Sbjct: 275 LHVDPHQRL-----TAALVLRHP 292 >3DAK-A nrPDB Length = 290 Score = 92.0 bits (227), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 79/293 (26%), Positives = 132/293 (45%), Gaps = 34/293 (11%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 + ++ + V+G G V A + A K++ ++ + E L E Q + + Sbjct: 7 INRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDEL--LKEIQAMSQ 64 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG------FPEARAVFYAAE 294 + +VS ++ KD L LV+ L++GG + I H+ G E+ E Sbjct: 65 CHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILRE 124 Query: 295 ICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI------KGRVGT 348 + GLE LH+ ++RD+K NILL + G ++I+D G++ + G I K VGT Sbjct: 125 VLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGT 184 Query: 349 VGYMAPEVVKNER-YTFSPDWWALGCLLYEMIAGQSPFQQR----------KKKIKREEV 397 +MAPEV++ R Y F D W+ G E+ G +P+ + + E Sbjct: 185 PCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLET 244 Query: 398 ERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 KE+ ++Y + F R + S L KDP +R +A E+ H F+K Sbjct: 245 GVQDKEMLKKYGKSF----RKMISLCLQKDPEKR-----PTAAELLRHKFFQK 288 >1TKI-A nrPDB Length = 321 Score = 91.3 bits (225), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 72/275 (26%), Positives = 125/275 (45%), Gaps = 19/275 (6%) Query: 183 KNTFRQYRV---LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQI-- 237 K + +Y + LG+G FG V C ++ K Y K + K KG L +K+I Sbjct: 1 KELYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFV------KVKGTDQVLVKKEISI 54 Query: 238 LEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 L R ++ L ++E+ + L ++ ++G D+ F + E V Y ++C Sbjct: 55 LNIARHRNILHLHESFESMEELVMIFEFISGLDI-FERINTSAFELNEREIVSYVHQVCE 113 Query: 298 GLEDLHRERIVYRDLKPENILLDDH--GHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPE 355 L+ LH I + D++PENI+ I+I + G A + G + Y APE Sbjct: 114 ALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPE 173 Query: 356 VVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQ 415 V +++ + + D W+LG L+Y +++G +PF + E + EE + S + Sbjct: 174 VHQHDVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIE 233 Query: 416 ARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 A +LL K+ R+ +A E +HP K+ Sbjct: 234 AMDFVDRLLVKERKSRM-----TASEALQHPWLKQ 263 >3UDB-A nrPDB Length = 317 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 78/271 (28%), Positives = 126/271 (46%), Gaps = 30/271 (11%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF-----V 246 +G G FG + + ++ A K +E+ GE + N K+ E +N R + Sbjct: 27 IGAGNFGVARLMRDKQANELVAVKYIER-------GEKIDENVKR--EIINHRSLRHPNI 77 Query: 247 VSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRER 306 V T L +V+ +GG+L I + G+ F E A F+ ++ G+ H + Sbjct: 78 VRFKEVILTPTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSYAHAMQ 135 Query: 307 IVYRDLKPENILLDDH--GHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTF 364 + +RDLK EN LLD ++I+D G + K VGT Y+APEV+ + Y Sbjct: 136 VAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLLKKEYDG 195 Query: 365 S-PDWWALGCLLYEMIAGQSPFQQ-RKKKIKREEVERLVK---EVPEEYSERFSPQARSL 419 D W+ G LY M+ G PF+ + K R+ + R++ +P+ SP+ R L Sbjct: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYV--HISPECRHL 253 Query: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 S++ DPA+R+ S E++ H F K Sbjct: 254 ISRIFVADPAKRI-----SIPEIRNHEWFLK 279 >4AN9-A nrPDB Length = 301 Score = 90.5 bits (223), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 74/254 (29%), Positives = 123/254 (48%), Gaps = 18/254 (7%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + F + LG G G V + +G + A +KL IK + + E Q+L + NS Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMA-RKLIHLEIKPAIRNQI-IRELQVLHECNS 66 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL- 302 ++V A+ + + + + M+GG L + G+ PE + + GL L Sbjct: 67 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLTYLR 124 Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR----VGTVGYMAPEVVK 358 + +I++RD+KP NIL++ G I++ D G++ GQ I VGT YM+PE ++ Sbjct: 125 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVS-----GQLIDEMANEFVGTRSYMSPERLQ 179 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEY-SERFSPQAR 417 Y+ D W++G L EM G+ P R E ++ +V E P + S FS + + Sbjct: 180 GTHYSVQSDIWSMGLSLVEMAVGRYP---RPPMAIFELLDYIVNEPPPKLPSAVFSLEFQ 236 Query: 418 SLCSQLLCKDPAER 431 ++ L K+PAER Sbjct: 237 DFVNKCLIKNPAER 250 >4QMW-A nrPDB Length = 310 Score = 90.1 bits (222), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 57/203 (28%), Positives = 98/203 (48%), Gaps = 6/203 (2%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 F + +GKG FGEV T K+ A K ++ + + + E +L + +S + Sbjct: 31 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSPY 88 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 V +Y L +++ + GG + + E + EI GL+ LH E Sbjct: 89 VTKYYGSYLKDTKLWIIMEYLGGGSA---LDLLEPGPLDETQIATILREILKGLDYLHSE 145 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR-VGTVGYMAPEVVKNERYTF 364 + ++RD+K N+LL +HG ++++D G+A + + Q + VGT +MAPEV+K Y Sbjct: 146 KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDS 205 Query: 365 SPDWWALGCLLYEMIAGQSPFQQ 387 D W+LG E+ G+ P + Sbjct: 206 KADIWSLGITAIELARGEPPHSE 228 >4KRC-A nrPDB Length = 317 Score = 90.1 bits (222), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 62/211 (29%), Positives = 104/211 (49%), Gaps = 11/211 (5%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 + + F+Q LG G + V + TG A K E K + + A+ E +++++ Sbjct: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALK--EVKLDSEEGTPSTAIREISLMKEL 60 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAV----FYAAEICC 297 +V L T++ L LV M+ DLK ++ P + ++ ++ Sbjct: 61 KHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQ 119 Query: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGL--AVHVPEGQTIKGRVGTVGYMAPE 355 GL H +I++RDLKP+N+L++ G +++ D GL A +P T V T+ Y AP+ Sbjct: 120 GLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPV-NTFSSEVVTLWYRAPD 178 Query: 356 VVKNER-YTFSPDWWALGCLLYEMIAGQSPF 385 V+ R Y+ S D W+ GC+L EMI G+ F Sbjct: 179 VLMGSRTYSTSIDIWSCGCILAEMITGKPLF 209 >5AIR-A nrPDB Length = 430 Score = 89.7 bits (221), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 82/302 (27%), Positives = 135/302 (44%), Gaps = 48/302 (15%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKK-LEKKRIKKRKGEAMALNEKQILEKVNS 243 ++ +V+G G FG V ++ +G++ A KK L+ KR K R E QI+ K++ Sbjct: 65 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR--------ELQIMRKLDH 116 Query: 244 RFVVSLAYAY----ETKDALCLVLTLMNGGDLKFHI---YHMGQAGFPEARAVFYAAEIC 296 +V L Y + E KD + L L L + + + Y + P Y ++ Sbjct: 117 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLF 176 Query: 297 CGLEDLHRERIVYRDLKPENILLD-DHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPE 355 L +H I +RD+KP+N+LLD D +++ D G A + G+ + + Y APE Sbjct: 177 RSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPE 236 Query: 356 VVKNER-YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERL--------VKEVPE 406 ++ YT S D W+ GC+L E++ GQ F + E+ ++ ++E+ Sbjct: 237 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 296 Query: 407 EYSE-----------------RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFK 449 Y+E R P+A +LCS+LL P RL + E H F Sbjct: 297 NYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL-----TPLEACAHSFFD 351 Query: 450 KL 451 +L Sbjct: 352 EL 353 >6HXF-B nrPDB Length = 302 Score = 88.6 bits (218), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 77/277 (27%), Positives = 127/277 (45%), Gaps = 30/277 (10%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 LG G FG+V + + TG + A K +E K ++ + + E +IL + ++V L Sbjct: 27 LGDGAFGKVYKAKNKETGALAAAKVIETKSEEELED---YIVEIEILATCDHPYIVKLLG 83 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 AY L +++ GG + + + + G E + ++ L LH +RI++RD Sbjct: 84 AYYHDGKLWIMIEFCPGGAVDAIMLELDR-GLTEPQIQVVCRQMLEALNFLHSKRIIHRD 142 Query: 312 LKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR---VGTVGYMAPEVV-----KNERYT 363 LK N+L+ G IR++D G V +T++ R +GT +MAPEVV K+ Y Sbjct: 143 LKAGNVLMTLEGDIRLADFG--VSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYD 200 Query: 364 FSPDWWALGCLLYEMIAGQSPFQQRKK-----KIKREEVERLVKEVPEEYSERFSPQARS 418 + D W+LG L EM + P + KI + + L+ P ++S F R Sbjct: 201 YKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLL--TPSKWSVEF----RD 254 Query: 419 LCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKR 455 L K+P R SA ++ EHP + + Sbjct: 255 FLKIALDKNPETR-----PSAAQLLEHPFVSSITSNK 286 >4BGQ-A nrPDB Length = 304 Score = 88.2 bits (217), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 61/236 (25%), Positives = 110/236 (46%), Gaps = 5/236 (2%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 N F V+G+G +G V C+ + T ++ A KK + + E L E ++L + Sbjct: 12 NKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKET-TLRELKMLRTLKQ 70 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 +V L A+ + L LV + L+ + G P + Y ++ + H Sbjct: 71 ENIVELKEAFRRRGKLYLVFEYVEKNMLE--LLEEMPNGVPPEKVKSYIYQLIKAIHWCH 128 Query: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIK--GRVGTVGYMAPEVVKNER 361 + IV+RD+KPEN+L+ + +++ D G A ++ EG V T Y +PE++ Sbjct: 129 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGAP 188 Query: 362 YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 Y S D W++GC+L E+ GQ F + + +++++ +P E + F R Sbjct: 189 YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPR 244 >6J5U-C nrPDB Length = 426 Score = 88.2 bits (217), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 72/220 (32%), Positives = 104/220 (47%), Gaps = 18/220 (8%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRAT---------GKMYACKKLEKKRIKKRKG 227 E + TKN FRQ +LG+GGFG V + T G + A K+L+ + + K Sbjct: 78 ELKNATKN-FRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGHKE 136 Query: 228 EAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEAR 287 +N L N V+ + Y E ++ L LV M G L+ H++ G A Sbjct: 137 WLTEVNYLGQLSHPN--LVLLVGYCAEGENRL-LVYEFMPKGSLENHLFRRGAQPLTWAI 193 Query: 288 AVFYAAEICCGLEDLH--RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR 345 + A GL LH + +++YRD K NILLD + ++SD GLA P G Sbjct: 194 RMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVS 253 Query: 346 ---VGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQ 382 +GT GY APE V R T D ++ G +L E+I+G+ Sbjct: 254 TKVIGTHGYAAPEYVATGRLTAKSDVYSFGVVLLELISGR 293 >2XIK-A nrPDB Length = 294 Score = 88.2 bits (217), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 56/200 (28%), Positives = 96/200 (48%), Gaps = 6/200 (3%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 F + +GKG FGEV T ++ A K ++ + + + E +L + +S + Sbjct: 21 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSPY 78 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 + +Y L +++ + GG + + E EI GL+ LH E Sbjct: 79 ITRYFGSYLKSTKLWIIMEYLGGGSA---LDLLKPGPLEETYIATILREILKGLDYLHSE 135 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR-VGTVGYMAPEVVKNERYTF 364 R ++RD+K N+LL + G ++++D G+A + + Q + VGT +MAPEV+K Y F Sbjct: 136 RKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDF 195 Query: 365 SPDWWALGCLLYEMIAGQSP 384 D W+LG E+ G+ P Sbjct: 196 KADIWSLGITAIELAKGEPP 215 >5AWM-A nrPDB Length = 394 Score = 88.2 bits (217), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 78/290 (26%), Positives = 121/290 (41%), Gaps = 51/290 (17%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 R +G G G VCA T + A KKL + + A E ++++ VN + ++ L Sbjct: 50 RPIGSGAQGIVCAAYDTITQQNVAIKKLSRP-FQNVTHAKRAYREFKLMKLVNHKNIIGL 108 Query: 250 AYAYETKDAL------CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 A+ + L LV+ LM+ + + Q R + ++ CG++ LH Sbjct: 109 LNAFTPQRNLEEFQDVYLVMELMDAN-----LCQVIQMDLDHDRMSYLLYQMLCGIKHLH 163 Query: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYT 363 I++RDLKP NI++ ++I D GLA + V T Y APEV+ YT Sbjct: 164 SAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYT 223 Query: 364 FSPDWWALGCLLYEMIAGQ----------------------SP-FQQRKKKIKREEVER- 399 + D W++GC++ EMI G SP F QR + R VE Sbjct: 224 ENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRNYVENR 283 Query: 400 ---------------LVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGC 434 L + S R + AR+L S++L DP +R+ Sbjct: 284 PRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISV 333 >6CKI-A nrPDB Length = 316 Score = 87.4 bits (215), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 88/296 (29%), Positives = 130/296 (43%), Gaps = 52/296 (17%) Query: 188 QYRVLGKGGFGEVCACQVRATGKMYACKKLEKK--RIKKRKGEAMALNEKQILEKVNS-R 244 Q VLG+G V C T + YA K +EK+ I+ R E ++L + R Sbjct: 17 QEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSR-----VFREVEMLYQCQGHR 71 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 V+ L +E +D LV M GG + HI+ + F E A ++ L+ LH Sbjct: 72 NVLELIEFFEEEDRFYLVFEKMRGGSILSHIHK--RRHFNELEASVVVQDVASALDFLHN 129 Query: 305 ERIVYRDLKPENILLDDHGH---IRISDLGLA-----------VHVPEGQTIKGRVGTVG 350 + I +RDLKPENIL + ++I D GL + PE T G+ Sbjct: 130 KGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLT---PCGSAE 186 Query: 351 YMAPEVV-----KNERYTFSPDWWALGCLLYEMIAGQSPFQQR---------------KK 390 YMAPEVV + Y D W+LG +LY +++G PF R + Sbjct: 187 YMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQ 246 Query: 391 KIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHP 446 + E ++ E P++ S A+ L S+LL +D +RL SA +V +HP Sbjct: 247 NMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRL-----SAAQVLQHP 297 >3ZUT-A nrPDB Length = 362 Score = 87.4 bits (215), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 77/271 (28%), Positives = 125/271 (46%), Gaps = 30/271 (11%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF-----V 246 +G G FG + + + ++ A K +E+ GE + N K+ E +N R + Sbjct: 27 IGSGNFGVARLMRDKQSNELVAVKYIER-------GEKIDENVKR--EIINHRSLRHPNI 77 Query: 247 VSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRER 306 V T L +V+ +GG+L I + G+ F E A F+ ++ G+ H + Sbjct: 78 VRFKEVILTPTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSYCHAMQ 135 Query: 307 IVYRDLKPENILLDDH--GHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTF 364 + +RDLK EN LLD ++I G + K VGT Y+APEV+ + Y Sbjct: 136 VCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDG 195 Query: 365 S-PDWWALGCLLYEMIAGQSPFQQ-RKKKIKREEVERLVK---EVPEEYSERFSPQARSL 419 D W+ G LY M+ G PF+ + K R+ + R++ +P+ SP+ R L Sbjct: 196 KVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYV--HISPECRHL 253 Query: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 S++ DPA+R+ S E++ H F K Sbjct: 254 ISRIFVADPAKRI-----SIPEIRNHEWFLK 279 >2PMN-X nrPDB Length = 348 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 85/325 (26%), Positives = 141/325 (43%), Gaps = 53/325 (16%) Query: 159 ADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLE 218 ++Y + IY N K+++ + N +R R L +G F ++ C+ K YA KK E Sbjct: 11 SNYSNLIYLN-----KYVKEKDKYINDYRIIRTLNQGKFNKIILCE--KDNKFYALKKYE 63 Query: 219 KKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLT-LMNGGDLKFHIY- 276 K ++K++ + N+K ++ F L + K+ CL ++ D + IY Sbjct: 64 KSLLEKKRDFTKSNNDKISIKSKYDDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYE 123 Query: 277 HMGQAGFPEARAVFYAAE-----------ICCGLED-------LHRER-IVYRDLKPENI 317 +M + F+ + I C ++ +H E+ I +RD+KP NI Sbjct: 124 YMENDSILKFDEYFFVLDKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNI 183 Query: 318 LLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE-RYTFSP-DWWALGCLL 375 L+D +G +++SD G + ++ + + IKG GT +M PE NE Y + D W+LG L Sbjct: 184 LMDKNGRVKLSDFGESEYMVDKK-IKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICL 242 Query: 376 YEMIAGQSPFQQRKKKIKREEVERLVK----EVPEEYSERFSP--QARSLCSQ------- 422 Y M PF KI E+ ++ E P + + P +S CS Sbjct: 243 YVMFYNVVPFSL---KISLVELFNNIRTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNED 299 Query: 423 ------LLCKDPAERLGCRGGSARE 441 L K+PAER+ E Sbjct: 300 IDFLKLFLRKNPAERITSEDALKHE 324 >3E7O-A nrPDB Length = 360 Score = 86.7 bits (213), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 60/207 (28%), Positives = 98/207 (47%), Gaps = 12/207 (5%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 ++Q + +G G G VCA G A KKL + + + A E +L+ VN + Sbjct: 24 YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP-FQNQTHAKRAYRELVLLKCVNHKN 82 Query: 246 VVSLAYAYETKDAL------CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 ++SL + + L LV+ LM+ + + HM R + ++ CG+ Sbjct: 83 IISLLNVFTPQKTLEEFQDVYLVMELMDANLCQ--VIHME---LDHERMSYLLYQMLCGI 137 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359 + LH I++RDLKP NI++ ++I D GLA + V T Y APEV+ Sbjct: 138 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYVVTRYYRAPEVILG 197 Query: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQ 386 Y + D W++GC++ E++ G FQ Sbjct: 198 MGYKENVDIWSVGCIMGELVKGSVIFQ 224 >5J5T-A nrPDB Length = 370 Score = 86.3 bits (212), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 84/323 (26%), Positives = 143/323 (44%), Gaps = 41/323 (12%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 ++ F + +G G +G+V + TG++ A K IK GE A+ +++I+ Sbjct: 2 SQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKV-----IKLEPGEDFAVVQQEIIMMK 56 Query: 242 NSRFVVSLAY--AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 + + +AY +Y +D L + + GG L+ IYH+ E + + + E GL Sbjct: 57 DCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQ-DIYHV-TGPLSELQIAYVSRETLQGL 114 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR---VGTVGYMAPEV 356 LH + ++RD+K NILL D+GH++++D G++ + TI R +GT +MAPEV Sbjct: 115 YYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQI--TATIAKRKAFIGTPYWMAPEV 172 Query: 357 VKNER---YTFSPDWWALGCLLYEMIAGQSP----------FQQRKKKIKREEVERLVKE 403 ER Y D WA+G E+ Q P F K + +++ +K Sbjct: 173 AAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMK- 231 Query: 404 VPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEP 463 +S F L K+P +R +A ++ +HP + + L +L+ Sbjct: 232 ----WSNSF----HHFVKMALTKNPKKR-----PTAEKLLQHPFVTQHLTRSLAIELLDK 278 Query: 464 PFKPDPQAIYCKDVLDIEQFSTV 486 PD + D D E V Sbjct: 279 VNNPDHSTYHDFDDDDPEPLVAV 301 >2HW6-A nrPDB Length = 307 Score = 86.3 bits (212), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 83/291 (28%), Positives = 130/291 (44%), Gaps = 48/291 (16%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV-NSRFVVSL 249 +LG+G + +V GK YA K +EK+ R + E + L + ++ ++ L Sbjct: 20 LLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSR---SRVFREVETLYQCQGNKNILEL 76 Query: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 +E LV + GG + HI Q F E A ++ L+ LH + I + Sbjct: 77 IEFFEDDTRFYLVFEKLQGGSILAHI--QKQKHFNEREASRVVRDVAAALDFLHTKGIAH 134 Query: 310 RDLKPENILLDDH---GHIRISDLGLA-----------VHVPEGQTIKGRVGTVGYMAPE 355 RDLKPENIL + ++I D L + PE T G+ YMAPE Sbjct: 135 RDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTT---PCGSAEYMAPE 191 Query: 356 VVK--NERYTFSP---DWWALGCLLYEMIAGQSPFQQR--------KKKIKR-------E 395 VV+ ++ TF D W+LG +LY M++G PF + ++ R E Sbjct: 192 VVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFE 251 Query: 396 EVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHP 446 ++ E P++ S +A+ L S+LL +D +RL SA +V +HP Sbjct: 252 SIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRL-----SAAQVLQHP 297 >5Y86-A nrPDB Length = 588 Score = 85.9 bits (211), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 56/198 (28%), Positives = 96/198 (48%), Gaps = 3/198 (1%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKL-EKKRIKKRKGEAMALNEK-QILEKVNSRFVV 247 +++GKG FG+V + A K + +KR ++ E + + E + +K S V+ Sbjct: 213 KIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVI 272 Query: 248 SLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERI 307 + ++ ++ +C+ L++ DL I GF +A I L+ LH+ +I Sbjct: 273 HMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKI 331 Query: 308 VYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPD 367 ++ DLKPENILL HG + E Q + + + Y APE++ RY+ D Sbjct: 332 IHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPID 391 Query: 368 WWALGCLLYEMIAGQSPF 385 W+ GC+L E++ GQ F Sbjct: 392 IWSFGCILAELLTGQPLF 409 >4NST-A nrPDB Length = 351 Score = 85.5 bits (210), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 66/230 (28%), Positives = 114/230 (49%), Gaps = 16/230 (6%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + F ++G+G +G+V + + TG++ A KK+ +K A+ E +IL ++ Sbjct: 13 DKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDN-EKEGFPITAIREIKILRQLIH 71 Query: 244 RFVVSLAYAY----------ETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAA 293 R VV++ + K A LV M+ DL + G F E + Sbjct: 72 RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDH-DL-MGLLESGLVHFSEDHIKSFMK 129 Query: 294 EICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA--VHVPEGQTIKGRVGTVGY 351 ++ GLE H++ ++RD+K NILL++ G I+++D GLA + E + +V T+ Y Sbjct: 130 QLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWY 189 Query: 352 MAPE-VVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERL 400 PE ++ ERYT + D W+ GC+L E+ + FQ + + E + RL Sbjct: 190 RPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRL 239 >4FZF-B nrPDB Length = 283 Score = 85.5 bits (210), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 70/268 (26%), Positives = 121/268 (45%), Gaps = 18/268 (6%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 F + +GKG FGEV T ++ A K ++ + + + E +L + +S + Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQ--QEITVLSQCDSSY 67 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG-FPEARAVFYAAEICCGLEDLHR 304 V +Y L +++ + GG + +AG F E + EI GL+ LH Sbjct: 68 VTKYYGSYLKGSKLWIIMEYLGGGS----ALDLLRAGPFDEFQIATMLKEILKGLDYLHS 123 Query: 305 ERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR-VGTVGYMAPEVVKNERYT 363 E+ ++RD+K N+LL + G ++++ G+A + + Q + VGT +MAPEV++ Y Sbjct: 124 EKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYD 183 Query: 364 FSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLV-KEVPEEYSERFSPQARSLCSQ 422 D W+LG E+ G+ P + V L+ K P F+ + Sbjct: 184 SKADIWSLGITAIELAKGEPP----NSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDA 239 Query: 423 LLCKDPAERLGCRGGSAREVKEHPLFKK 450 L KDP+ R +A+E+ +H K Sbjct: 240 CLNKDPSFR-----PTAKELLKHKFIVK 262 >3FXW-A nrPDB Length = 336 Score = 85.5 bits (210), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 72/263 (27%), Positives = 115/263 (43%), Gaps = 19/263 (7%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 VT + +VLG G G+V C R TG+ A K L +++ + + Sbjct: 26 VTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVD-------HHWQA 78 Query: 241 VNSRFVVSLAYAYET----KDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 +V + YE K L +++ M GG+L I G F E A +I Sbjct: 79 SGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIG 138 Query: 297 CGLEDLHRERIVYRDLKPENILL---DDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMA 353 ++ LH I +RD+KPEN+L + ++++D G A + ++ T Y+A Sbjct: 139 TAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQN-ALQTPCYTPYYVA 197 Query: 354 PEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVK----EVPEEYS 409 PEV+ E+Y S D W+LG ++Y ++ G PF + ++R ++ P Sbjct: 198 PEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEW 257 Query: 410 ERFSPQARSLCSQLLCKDPAERL 432 S A+ L LL DP ERL Sbjct: 258 SEVSEDAKQLIRLLLKTDPTERL 280 >2BRG-A nrPDB Length = 297 Score = 85.5 bits (210), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 65/209 (31%), Positives = 103/209 (49%), Gaps = 22/209 (10%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKR-------IKKRKGEAMALNEKQILEKVN 242 + LG+G +GEV R T + A K ++ KR IKK LN + +++ Sbjct: 13 QTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYG 72 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 R ++ Y L L +GG+L I G PE A + ++ G+ L Sbjct: 73 HRREGNIQY---------LFLEYCSGGELFDRIE--PDIGMPEPDAQRFFHQLMAGVVYL 121 Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAV---HVPEGQTIKGRVGTVGYMAPEVVKN 359 H I +RD+KPEN+LLD+ +++ISD GLA + + + GT+ Y+APE++K Sbjct: 122 HGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKR 181 Query: 360 ERYTFSP-DWWALGCLLYEMIAGQSPFQQ 387 + P D W+ G +L M+AG+ P+ Q Sbjct: 182 REFHAEPVDVWSCGIVLTAMLAGELPWDQ 210 >4MYG-A nrPDB Length = 372 Score = 85.1 bits (209), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 74/292 (25%), Positives = 133/292 (45%), Gaps = 47/292 (16%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 +G G +G VC+ + +G+ A KKL + + A E +L+ + V+ L Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRP-FQSEIFAKRAYRELLLLKHMQHENVIGLLD 109 Query: 252 AYETKDAL------CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 + +L LV+ M K MG F E + + ++ GL+ +H Sbjct: 110 VFTPASSLRNFYDFYLVMPFMQTDLQKI----MGME-FSEEKIQYLVYQMLKGLKYIHSA 164 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN-ERYTF 364 +V+RDLKP N+ +++ ++I D GLA H T G V T Y APEV+ + Y Sbjct: 165 GVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMT--GYVVTRWYRAPEVILSWMHYNQ 222 Query: 365 SPDWWALGCLLYEMIAGQSPFQQRK--------------------KKIKREEVERLVKEV 404 + D W++GC++ EM+ G++ F+ + +K+ + + ++ + Sbjct: 223 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL 282 Query: 405 PE----EYSERF---SPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFK 449 P+ ++++ F SPQA L ++L D +RL +A + HP F+ Sbjct: 283 PQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL-----TAAQALTHPFFE 329 >5HI2-A nrPDB Length = 283 Score = 85.1 bits (209), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 61/207 (29%), Positives = 97/207 (46%), Gaps = 31/207 (14%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 +G G FG V + A K L ++++ K E L + + VN + L Sbjct: 28 IGSGSFGTVYKGKWHGD---VAVKMLTPQQLQAFKNEVGVLRKTR---HVN----ILLFM 77 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 Y TK L +V G L +H H + F + + A + G++ LH + I++RD Sbjct: 78 GYSTKPQLAIVTQWCEGSSL-YHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRD 136 Query: 312 LKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR----------VGTVGYMAPEVVKNER 361 LK NI L + ++I D GLA T+K R G++ +MAPEV++ + Sbjct: 137 LKSNNIFLHEDNTVKIGDFGLA-------TVKSRWSGSHQFEQLSGSILWMAPEVIRMQD 189 Query: 362 ---YTFSPDWWALGCLLYEMIAGQSPF 385 Y+F D +A G +LYE++ GQ P+ Sbjct: 190 SNPYSFQSDVYAFGIVLYELMTGQLPY 216 >3ZDU-A nrPDB Length = 325 Score = 84.7 bits (208), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 60/203 (29%), Positives = 97/203 (47%), Gaps = 9/203 (4%) Query: 185 TFRQYRVLGK---GGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 + Y LGK G +G V C+ + TG++ A K ++ ++ +A+ E + L++ Sbjct: 1 SMEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYER--PEQSVNKIAMREIKFLKQF 58 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 + +V+L + K + LV ++ L + H G R Y +I ++ Sbjct: 59 HHENLVNLIEVFRQKKKIHLVFEFIDHTVLD-ELQHYCH-GLESKRLRKYLFQILRAIDY 116 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPE-GQTIKGRVGTVGYMAPE-VVKN 359 LH I++RD+KPENIL+ G ++ D G A + G V T Y APE V+K+ Sbjct: 117 LHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKD 176 Query: 360 ERYTFSPDWWALGCLLYEMIAGQ 382 Y D WALGC++ EM G Sbjct: 177 TSYGKPVDIWALGCMIIEMATGN 199 >3OHT-A nrPDB Length = 389 Score = 84.7 bits (208), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 66/240 (27%), Positives = 112/240 (46%), Gaps = 15/240 (6%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL-- 249 +G G +G VC+ +G A KKL + + E ++L+ + V+ L Sbjct: 59 VGSGAYGSVCSSYDVKSGLKIAVKKLSRP-FQSIIHAKRTYRELRLLKHMKHENVIGLLD 117 Query: 250 ----AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 A + E + + LV LM G DL + + F +I GL+ +H Sbjct: 118 VFTPATSLEEFNDVYLVTHLM-GADLNNIV---KCQKLTDDHVQFLIYQILRGLKYIHSA 173 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN-ERYTF 364 I++RDLKP N+ +++ ++I D GLA H + T G V T Y APE++ N Y Sbjct: 174 DIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT--GYVATRWYRAPEIMLNWMHYNM 231 Query: 365 SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERF-SPQARSLCSQL 423 + D W++GC++ E++ G++ F + +++ RL P R S +AR+ + L Sbjct: 232 TVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASVISRMPSHEARNYINSL 291 >5ZTN-A nrPDB Length = 429 Score = 84.7 bits (208), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 59/200 (29%), Positives = 100/200 (50%), Gaps = 15/200 (7%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKL-EKKRIKKRKGEAMALNEK-QILEKVNSRFVV 247 +V+GKG FG+V + A K + +KR ++ E + + E + +K N+ V+ Sbjct: 103 KVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVI 162 Query: 248 SLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQA----GFPEARAVFYAAEICCGLEDLH 303 + + ++ +C+ L L ++Y + + GF +A I L+ LH Sbjct: 163 HMLENFTFRNHICMTFEL-----LSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALH 217 Query: 304 RERIVYRDLKPENILLDDHGH--IRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER 361 + RI++ DLKPENILL G I++ D G + + E Q + + + Y APEV+ R Sbjct: 218 KNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCY--EHQRVYTYIQSRFYRAPEVILGAR 275 Query: 362 YTFSPDWWALGCLLYEMIAG 381 Y D W+LGC+L E++ G Sbjct: 276 YGMPIDMWSLGCILAELLTG 295 >5HIE-A nrPDB Length = 302 Score = 84.7 bits (208), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 73/273 (26%), Positives = 123/273 (45%), Gaps = 43/273 (15%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 +G G FG V + A K L ++++ K E L + + VN + L Sbjct: 44 IGSGSFGTVYKGKWHGD---VAVKMLTPQQLQAFKNEVGVLRKTR---HVN----ILLFM 93 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 Y TK L +V G L +H H+ + F + + A + G++ LH + I++RD Sbjct: 94 GYSTKPQLAIVTQWCEGSSL-YHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRD 152 Query: 312 LKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR----------VGTVGYMAPEVVKNER 361 LK NI L + ++I D GLA T+K R G++ +MAPEV++ + Sbjct: 153 LKSNNIFLHEDLTVKIGDFGLA-------TVKSRWSGSHQFEQLSGSILWMAPEVIRMQD 205 Query: 362 ---YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARS 418 Y+F D +A G +LYE++ GQ P+ + ++++ V Y + RS Sbjct: 206 KNPYSFQSDVYAFGIVLYELMTGQLPYSNINNR------DQIIFMVGRGYLSPDLSKVRS 259 Query: 419 LCSQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 C + + + AE L ++ E PLF ++ Sbjct: 260 NCPKAMKRLMAECL------KKKRDERPLFPQI 286 >1V0B-A nrPDB Length = 288 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 75/290 (25%), Positives = 138/290 (47%), Gaps = 40/290 (13%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKG-EAMALNEKQILEKVNSRFVVSLA 250 +G+G +G V Q G+ +A KK+ + K+ +G + + E IL+++ +V L Sbjct: 10 IGEGTYGVVYKAQ-NNYGETFALKKIRLE--KEDEGIPSTTIREISILKELKHSNIVKLY 66 Query: 251 YAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYR 310 TK L LV ++ DLK + + + G A + ++ G+ H R+++R Sbjct: 67 DVIHTKKRLVLVFEHLDQ-DLK-KLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRRVLHR 124 Query: 311 DLKPENILLDDHGHIRISDLGL--AVHVPEGQTIKGRVGTVGYMAPEVVK-NERYTFSPD 367 DLKP+N+L++ G ++I+D GL A +P + V T+ Y AP+V+ +++Y+ + D Sbjct: 125 DLKPQNLLINREGELKIADFGLARAFGIPV-RKYTHEVVTLWYRAPDVLMGSKKYSTTID 183 Query: 368 WWALGCLLYEMIAGQSPFQQRKKKIKREEVERL-----------VKEVP----------- 405 W++GC+ EM+ G F + + + R+ V E+P Sbjct: 184 IWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPNFTVYEP 243 Query: 406 ---EEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 E + + L S++L DP +R+ +A++ EH FK+ N Sbjct: 244 LPWESFLKGLDESGIDLLSKMLKLDPNQRI-----TAKQALEHAYFKENN 288 >3FI2-A nrPDB Length = 353 Score = 84.0 bits (206), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 75/305 (24%), Positives = 130/305 (42%), Gaps = 55/305 (18%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 ++ + +G G G VCA + A KKL + + + A E +++ VN + Sbjct: 26 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP-FQNQTHAKRAYRELVLMKCVNHKN 84 Query: 246 VVSLAYAYETKDAL------CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 ++SL + + L LV+ LM+ ++ + Q R + ++ CG+ Sbjct: 85 IISLLNVFTPQKTLEEFQDVYLVMELMDA-----NLCQVIQMELDHERMSYLLYQMLCGI 139 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359 + LH I++RDLKP NI++ ++I D GLA + V T Y APEV+ Sbjct: 140 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILG 199 Query: 360 ERYTFSPDWWALGCLLYEMI------AGQSPFQQRKKKIK-------------REEVERL 400 Y + D W++GC++ EM+ G+ Q K I+ + V Sbjct: 200 MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNY 259 Query: 401 VKEVPE-------------------EYSERFSPQARSLCSQLLCKDPAERLGCRGGSARE 441 V+ P+ E+++ + QAR L S++L DPA+R+ S + Sbjct: 260 VENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI-----SVDD 314 Query: 442 VKEHP 446 +HP Sbjct: 315 ALQHP 319 >3COM-A nrPDB Length = 314 Score = 84.0 bits (206), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 75/287 (26%), Positives = 122/287 (42%), Gaps = 26/287 (9%) Query: 172 QWKWLERQPVTKN---TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGE 228 Q K L+ +TK F LG+G +G V + TG++ A K++ + + Sbjct: 14 QLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE--- 70 Query: 229 AMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARA 288 + E I+++ +S VV +Y L +V+ G + I + E Sbjct: 71 --IIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVS-DIIRLRNKTLTEDEI 127 Query: 289 VFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRV-G 347 GLE LH R ++RD+K NILL+ GH +++D G+A + + + V G Sbjct: 128 ATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIG 187 Query: 348 TVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKK-----KIKREEVERLVK 402 T +MAPEV++ Y D W+LG EM G+ P+ I K Sbjct: 188 TPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRK 247 Query: 403 EVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFK 449 PE +S+ F+ Q L K P +R +A ++ +HP + Sbjct: 248 --PELWSDNFT----DFVKQCLVKSPEQR-----ATATQLLQHPFVR 283 >1JNK-A nrPDB Length = 423 Score = 84.0 bits (206), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 75/305 (24%), Positives = 130/305 (42%), Gaps = 55/305 (18%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 ++ + +G G G VCA + A KKL + + + A E +++ VN + Sbjct: 64 YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP-FQNQTHAKRAYRELVLMKCVNHKN 122 Query: 246 VVSLAYAYETKDAL------CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 ++SL + + L LV+ LM+ ++ + Q R + ++ CG+ Sbjct: 123 IISLLNVFTPQKTLEEFQDVYLVMELMDA-----NLCQVIQMELDHERMSYLLYQMLCGI 177 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359 + LH I++RDLKP NI++ ++I D GLA + V T Y APEV+ Sbjct: 178 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILG 237 Query: 360 ERYTFSPDWWALGCLLYEMI------AGQSPFQQRKKKIK-------------REEVERL 400 Y + D W++GC++ EM+ G+ Q K I+ + V Sbjct: 238 MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNY 297 Query: 401 VKEVPE-------------------EYSERFSPQARSLCSQLLCKDPAERLGCRGGSARE 441 V+ P+ E+++ + QAR L S++L DPA+R+ S + Sbjct: 298 VENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI-----SVDD 352 Query: 442 VKEHP 446 +HP Sbjct: 353 ALQHP 357 >5EFQ-A nrPDB Length = 347 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 62/230 (26%), Positives = 114/230 (49%), Gaps = 16/230 (6%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + F ++G+G +G+V + + TG+M A KK+ +K A+ E +IL ++ Sbjct: 11 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDN-EKEGFPITAIREIKILRQLTH 69 Query: 244 RFVVSLAYAYETKD----------ALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAA 293 + ++++ K+ A LV M+ DL + G F E + Sbjct: 70 QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDH-DL-MGLLESGLVHFNENHIKSFMR 127 Query: 294 EICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA--VHVPEGQTIKGRVGTVGY 351 ++ GL+ H++ ++RD+K NILL++ G I+++D GLA E + +V T+ Y Sbjct: 128 QLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWY 187 Query: 352 MAPE-VVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERL 400 PE ++ ERYT + D W+ GC+L E+ + FQ ++ + E + R+ Sbjct: 188 RPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRI 237 >5KKR-C nrPDB Length = 395 Score = 83.2 bits (204), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 60/207 (28%), Positives = 100/207 (48%), Gaps = 14/207 (6%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + F + LG G G V + +G + A +KL IK + + E Q+L + NS Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMA-RKLIHLEIKPAIRNQI-IRELQVLHECNS 125 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL- 302 ++V A+ + + + + M+GG L + G+ PE + + GL L Sbjct: 126 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLTYLR 183 Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR----VGTVGYMAPEVVK 358 + +I++RD+KP NIL++ G I++ D G++ GQ I VGT YM+PE ++ Sbjct: 184 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVS-----GQLIDSMANSFVGTRSYMSPERLQ 238 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPF 385 Y+ D W++G L EM G+ P Sbjct: 239 GTHYSVQSDIWSMGLSLVEMAVGRYPI 265 >3GC9-A nrPDB Length = 370 Score = 83.2 bits (204), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 80/300 (26%), Positives = 130/300 (43%), Gaps = 52/300 (17%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEK---KRIKKRKGEAMALNEKQILEKVNSRFV 246 R +G G +G VC+ + A KKL + I R+ E ++L+ + V Sbjct: 34 RPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR----TYRELRLLKHLKHENV 89 Query: 247 VSL------AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 + L A + E + LV TLM G DL + + F ++ GL+ Sbjct: 90 IGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIV---KSQALSDEHVQFLVYQLLRGLK 145 Query: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN- 359 +H I++RDLKP N+ +++ +RI D GLA E T G V T Y APE++ N Sbjct: 146 YIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEEMT--GYVATRWYRAPEIMLNW 203 Query: 360 ERYTFSPDWWALGCLLYEMIAGQSPF------QQRKK--------------KIKREEVER 399 Y + D W++GC++ E++ G++ F Q K+ KI E Sbjct: 204 MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHART 263 Query: 400 LVKEVP----EEYSERF---SPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 ++ +P ++ S F +P A L ++L D +R+ SA E H F + + Sbjct: 264 YIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV-----SAAEALAHAYFSQYH 318 >1UA2-A nrPDB Length = 346 Score = 83.2 bits (204), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 61/198 (30%), Positives = 102/198 (51%), Gaps = 6/198 (3%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLE-KKRIKKRKG-EAMALNEKQILEKVNS 243 + + LG+G F V + + T ++ A KK++ R + + G AL E ++L++++ Sbjct: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 ++ L A+ K + LV M DL+ I P + Y GLE LH Sbjct: 72 PNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTP-SHIKAYMLMTLQGLEYLH 129 Query: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPE-GQTIKGRVGTVGYMAPEVVKNER- 361 + I++RDLKP N+LLD++G ++++D GLA + +V T Y APE++ R Sbjct: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189 Query: 362 YTFSPDWWALGCLLYEMI 379 Y D WA+GC+L E++ Sbjct: 190 YGVGVDMWAVGCILAELL 207 >1S9I-A nrPDB Length = 354 Score = 82.4 bits (202), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 61/207 (29%), Positives = 100/207 (48%), Gaps = 14/207 (6%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + F + LG G G V Q R +G + A +KL IK + + E Q+L + NS Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMA-RKLIHLEIKPAIRNQI-IRELQVLHECNS 73 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL- 302 ++V A+ + + + + M+GG L + + PE + + GL L Sbjct: 74 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKR--IPEEILGKVSIAVLRGLAYLR 131 Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR----VGTVGYMAPEVVK 358 + +I++RD+KP NIL++ G I++ D G++ GQ I VGT YMAPE ++ Sbjct: 132 EKHQIMHRDVKPSNILVNSRGEIKLCDFGVS-----GQLIDSMANSFVGTRSYMAPERLQ 186 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPF 385 Y+ D W++G L E+ G+ P Sbjct: 187 GTHYSVQSDIWSMGLSLVELAVGRYPI 213 >3EQC-A nrPDB Length = 360 Score = 82.4 bits (202), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 57/203 (28%), Positives = 99/203 (48%), Gaps = 6/203 (2%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + F + LG G G V + +G + A +KL IK + + E Q+L + NS Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMA-RKLIHLEIKPAIRNQI-IRELQVLHECNS 90 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL- 302 ++V A+ + + + + M+GG L + G+ PE + + GL L Sbjct: 91 PYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGLTYLR 148 Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERY 362 + +I++RD+KP NIL++ G I++ D G++ + + VGT YM+PE ++ Y Sbjct: 149 EKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-NSFVGTRSYMSPERLQGTHY 207 Query: 363 TFSPDWWALGCLLYEMIAGQSPF 385 + D W++G L EM G+ P Sbjct: 208 SVQSDIWSMGLSLVEMAVGRYPI 230 >5Z33-A nrPDB Length = 425 Score = 82.4 bits (202), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 80/309 (25%), Positives = 136/309 (44%), Gaps = 56/309 (18%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKL----EKKRIKKRKGEAMAL 232 ER VTK LG+G +G VCA T + A KK+ KK + KR AL Sbjct: 31 ERYTVTKE-------LGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKR-----AL 78 Query: 233 NEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVF-- 290 E ++L+ ++ Y + T + ++ + + ++G P A F Sbjct: 79 REIKLLQHFRGHRNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQS 138 Query: 291 YAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV---PEGQT--IKGR 345 + +I CGL+ +H +++RDLKP N+L++ ++I D GLA PE + Sbjct: 139 FIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEY 198 Query: 346 VGTVGYMAPEVVKN-ERYTFSPDWWALGCLLYEMIAGQ--------------------SP 384 V T Y APE++ + + YT + D W++GC+L E++ G+ +P Sbjct: 199 VATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTP 258 Query: 385 FQQRKKKIKREEVERLVKEVPEEYSERF-------SPQARSLCSQLLCKDPAERLGCRGG 437 ++ +I + V+ +P + F +P A L ++L DP+ R+ Sbjct: 259 NEETLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRI----- 313 Query: 438 SAREVKEHP 446 S + EHP Sbjct: 314 SVEQALEHP 322 >4EWQ-A nrPDB Length = 383 Score = 82.4 bits (202), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 68/244 (27%), Positives = 113/244 (46%), Gaps = 14/244 (5%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL-- 249 +G G +G VCA TG A KKL + + E ++L+ + V+ L Sbjct: 53 VGSGAYGSVCAAFDTKTGLRVAVKKLSRP-FQSIIHAKRTYRELRLLKHMKHENVIGLLD 111 Query: 250 ----AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 A + E + + LV LM G DL + + F +I GL+ +H Sbjct: 112 VFTPARSLEEFNDVYLVTHLM-GADLNNIV---KCQKLTDDHVQFLIYQILRGLKYIHSA 167 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN-ERYTF 364 I++RDLKP N+ +++ ++I D GLA H + T G V T Y APE++ N Y Sbjct: 168 DIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT--GYVATRWYRAPEIMLNWMHYNQ 225 Query: 365 SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLL 424 + D W++GC++ E++ G++ F + + + RLV E ++ S ++ Q L Sbjct: 226 TVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSL 285 Query: 425 CKDP 428 + P Sbjct: 286 TQMP 289 >4EQM-A nrPDB Length = 294 Score = 82.0 bits (201), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 61/202 (30%), Positives = 95/202 (47%), Gaps = 14/202 (6%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKL-----EKKRIKKRKGEAMALNEKQILEKVNSRFV 246 LG GG V + A K + EK+ KR E N Q+ + + + Sbjct: 19 LGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKR-FEREVHNSSQL----SHQNI 73 Query: 247 VSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRER 306 VS+ E D LV+ + G L +I G A+ + +I G++ H R Sbjct: 74 VSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLSVD--TAINFTNQILDGIKHAHDMR 131 Query: 307 IVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR--VGTVGYMAPEVVKNERYTF 364 IV+RD+KP+NIL+D + ++I D G+A + E + +GTV Y +PE K E Sbjct: 132 IVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQAKGEATDE 191 Query: 365 SPDWWALGCLLYEMIAGQSPFQ 386 D +++G +LYEM+ G+ PF Sbjct: 192 CTDIYSIGIVLYEMLVGEPPFN 213 >4BBM-A nrPDB Length = 331 Score = 82.0 bits (201), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 59/201 (29%), Positives = 100/201 (49%), Gaps = 13/201 (6%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKL----EKKRIKKRKGEAMALNEKQILEKVNSRFV 246 ++G+G +G V C+ + TG++ A KK + K +KK +A+ E ++L+++ + Sbjct: 32 LVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKK-----IAMREIKLLKQLRHENL 86 Query: 247 VSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRER 306 V+L + K LV ++ L + G Y +I G+ H Sbjct: 87 VNLLEVCKKKKRWYLVFEFVDHTILD--DLELFPNGLDYQVVQKYLFQIINGIGFCHSHN 144 Query: 307 IVYRDLKPENILLDDHGHIRISDLGLAVHVPE-GQTIKGRVGTVGYMAPE-VVKNERYTF 364 I++RD+KPENIL+ G +++ D G A + G+ V T Y APE +V + +Y Sbjct: 145 IIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGDVKYGK 204 Query: 365 SPDWWALGCLLYEMIAGQSPF 385 + D WA+GCL+ EM G+ F Sbjct: 205 AVDVWAIGCLVTEMFMGEPLF 225 >4HVI-A nrPDB Length = 314 Score = 82.0 bits (201), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 58/200 (29%), Positives = 101/200 (50%), Gaps = 16/200 (8%) Query: 192 LGKGGFGEVCACQVRA----TGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVV 247 LGKG FG V C+ TG + A K+L+ +++ E QIL+ ++S F+V Sbjct: 18 LGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQ---REIQILKALHSDFIV 74 Query: 248 ---SLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 ++Y + +L LV+ + G L+ +A +R + Y+++IC G+E L Sbjct: 75 KYRGVSYG-PGRQSLRLVMEYLPSGCLR-DFLQRHRARLDASRLLLYSSQICKGMEYLGS 132 Query: 305 ERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI----KGRVGTVGYMAPEVVKNE 360 R V+RDL NIL++ H++I+D GLA +P + + + + APE + + Sbjct: 133 RRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDN 192 Query: 361 RYTFSPDWWALGCLLYEMIA 380 ++ D W+ G +LYE+ Sbjct: 193 IFSRQSDVWSFGVVLYELFT 212 >3OMV-A nrPDB Length = 307 Score = 81.6 bits (200), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 51/162 (31%), Positives = 85/162 (52%), Gaps = 10/162 (6%) Query: 233 NEKQILEKVNSRFV-VSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFY 291 NE +L K +R V + L Y TKD L +V G L H+ H+ + F + + Sbjct: 81 NEVAVLRK--TRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHL-HVQETKFQMFQLIDI 137 Query: 292 AAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAV---HVPEGQTIKGRVGT 348 A + G++ LH + I++RD+K NI L + ++I D GLA Q ++ G+ Sbjct: 138 ARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGS 197 Query: 349 VGYMAPEVVK---NERYTFSPDWWALGCLLYEMIAGQSPFQQ 387 V +MAPEV++ N ++F D ++ G +LYE++ G+ P+ Sbjct: 198 VLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSH 239 >6AO5-A nrPDB Length = 362 Score = 81.3 bits (199), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 69/281 (24%), Positives = 120/281 (42%), Gaps = 27/281 (9%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEK 235 L +QP + F LG+G +G V + +G++ A K++ + + + E Sbjct: 4 LTKQP--EEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQE-----IIKEI 56 Query: 236 QILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEI 295 I+++ +S +VV +Y L +V+ G + I + E Sbjct: 57 SIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVS-DIIRLRNKTLIEDEIATILKST 115 Query: 296 CCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRV-GTVGYMAP 354 GLE LH R ++R++K NILL+ GH +++D G+A + + + V GT +MAP Sbjct: 116 LKGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAP 175 Query: 355 EVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEE------Y 408 EV++ Y D W+LG EM G+ P+ R + +P Sbjct: 176 EVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPM-------RAIFMIPTNPPPTFRK 228 Query: 409 SERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFK 449 E +S + L K+P +R +A ++ +HP K Sbjct: 229 PELWSDDFTDFVKKCLVKNPEQR-----ATATQLLQHPFIK 264 >5G6V-A nrPDB Length = 324 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 55/205 (26%), Positives = 107/205 (52%), Gaps = 10/205 (4%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGE-AMALNEKQILEKVNS 243 T+ + LG+G + V + + T + A K++ R++ +G A+ E +L+ + Sbjct: 3 TYIKLDKLGEGTYATVYKGKSKLTDNLVALKEI---RLEHEEGAPCTAIREVSLLKDLKH 59 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 +V+L T+ +L LV ++ DLK ++ G + ++ GL H Sbjct: 60 ANIVTLHDIIHTEKSLTLVFEYLDK-DLKQYLDDCGNI-INMHNVKLFLFQLLRGLAYCH 117 Query: 304 RERIVYRDLKPENILLDDHGHIRISDLGL--AVHVPEGQTIKGRVGTVGYMAPEV-VKNE 360 R+++++RDLKP+N+L+++ G ++++D GL A +P +T V T+ Y P++ + + Sbjct: 118 RQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPT-KTYDNEVVTLWYRPPDILLGST 176 Query: 361 RYTFSPDWWALGCLLYEMIAGQSPF 385 Y+ D W +GC+ YEM G+ F Sbjct: 177 DYSTQIDMWGVGCIFYEMATGRPLF 201 >4LG4-A nrPDB Length = 299 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 71/280 (25%), Positives = 122/280 (43%), Gaps = 25/280 (8%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEK 235 L +QP + F LG+G +G V + +G++ A K++ + + + E Sbjct: 5 LTKQP--EEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQE-----IIKEI 57 Query: 236 QILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEI 295 I+++ +S +VV +Y L +V+ G + I + E Sbjct: 58 SIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVS-DIIRLRNKTLIEDEIATILKST 116 Query: 296 CCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRV-GTVGYMAP 354 GLE LH R ++R++K NILL+ GH +++D G+A + + + V GT +MAP Sbjct: 117 LKGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAP 176 Query: 355 EVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKK-----KIKREEVERLVKEVPEEYS 409 EV++ Y D W+LG EM G+ P+ I K PE +S Sbjct: 177 EVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRK--PELWS 234 Query: 410 ERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFK 449 + F+ + L K+P +R +A ++ +HP K Sbjct: 235 DDFT----DFVKKCLVKNPEQR-----ATATQLLQHPFIK 265 >3VN9-A nrPDB Length = 340 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 66/271 (24%), Positives = 127/271 (46%), Gaps = 29/271 (10%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 LG+G +G V + +G++ A K++ + + ++ + + ++ + V+ F V+ Sbjct: 59 LGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 117 Query: 252 AYETKDALCLVLTLMNGGDLKFH--IYHMGQAGFPEARAVFYAAEICCGLEDLHRE-RIV 308 A + + + + LM+ KF+ + GQ PE A I LE LH + ++ Sbjct: 118 ALFREGDVWICMELMDTSLDKFYKQVIDKGQT-IPEDILGKIAVSIVKALEHLHSKLSVI 176 Query: 309 YRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER----YTF 364 +RD+KP N+L++ G +++ D G++ ++ + G YMAPE + E Y+ Sbjct: 177 HRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSV 236 Query: 365 SPDWWALGCLLYEMI-------AGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 D W+LG + E+ + +PFQQ K+ ++ P+ +++FS + Sbjct: 237 KSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPS--------PQLPADKFSAEFV 288 Query: 418 SLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 SQ L K+ ER + E+ +HP F Sbjct: 289 DFTSQCLKKNSKER-----PTYPELMQHPFF 314 >2UV2-A nrPDB Length = 325 Score = 80.9 bits (198), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 74/285 (25%), Positives = 128/285 (44%), Gaps = 31/285 (10%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI 222 +++YF Q++ + R ++ + LG G FG+V Q + T + A K ++ K Sbjct: 16 ENLYFQSMKQYEHVTRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSE 75 Query: 223 KKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG 282 ++ + + ++ IL + +V L A+ ++ L +++ GG + + + + Sbjct: 76 EELEDYMVEID---ILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLEL-ERP 131 Query: 283 FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI 342 E++ + L LH +I++RDLK NIL G I+++D G V +TI Sbjct: 132 LTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFG--VSAKNTRTI 189 Query: 343 KGR---VGTVGYMAPEVV-----KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKK---- 390 + R +GT +MAPEVV K+ Y + D W+LG L EM + P + Sbjct: 190 QRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVL 249 Query: 391 -KIKREEVERLVKEVPEEYSERF----------SPQARSLCSQLL 424 KI + E L + P +S F + AR SQLL Sbjct: 250 LKIAKSEPPTLAQ--PSRWSSNFKDFLKKCLEKNVDARWTTSQLL 292 >2F9G-A nrPDB Length = 353 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 75/309 (24%), Positives = 135/309 (43%), Gaps = 56/309 (18%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL-----EK 240 F+ +LG+G +G VC+ + TG++ A KK+E K L E +IL E Sbjct: 13 FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP--FDKPLFALRTLREIKILKHFKHEN 70 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 + + F + ++E + + ++ LM DL I + ++ + ++ Sbjct: 71 IITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVI---STQMLSDDHIQYFIYQTLRAVK 126 Query: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV---------PEGQT--IKGRVGTV 349 LH +++RDLKP N+L++ + +++ D GLA + P GQ + V T Sbjct: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 Query: 350 GYMAPEV-VKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKK----------------- 391 Y APEV + + +Y+ + D W+ GC+L E+ + F R + Sbjct: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Query: 392 ----IKREEVERLVKEVP-------EEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAR 440 I+ +K +P E+ R +P+ L ++L DPA+R+ +A+ Sbjct: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI-----TAK 301 Query: 441 EVKEHPLFK 449 E EHP + Sbjct: 302 EALEHPYLQ 310 >3FME-A nrPDB Length = 290 Score = 80.1 bits (196), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 66/271 (24%), Positives = 127/271 (46%), Gaps = 29/271 (10%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 LG+G +G V + +G++ A K++ + + ++ + + ++ + V+ F V+ Sbjct: 15 LGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 73 Query: 252 AYETKDALCLVLTLMNGGDLKFH--IYHMGQAGFPEARAVFYAAEICCGLEDLHRE-RIV 308 A + + + + LM+ KF+ + GQ PE A I LE LH + ++ Sbjct: 74 ALFREGDVWICMELMDTSLDKFYKQVIDKGQT-IPEDILGKIAVSIVKALEHLHSKLSVI 132 Query: 309 YRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER----YTF 364 +RD+KP N+L++ G +++ D G++ ++ + G YMAPE + E Y+ Sbjct: 133 HRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPERINPELNQKGYSV 192 Query: 365 SPDWWALGCLLYEMI-------AGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 D W+LG + E+ + +PFQQ K+ ++ P+ +++FS + Sbjct: 193 KSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPS--------PQLPADKFSAEFV 244 Query: 418 SLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 SQ L K+ ER + E+ +HP F Sbjct: 245 DFTSQCLKKNSKER-----PTYPELMQHPFF 270 >6DTL-A nrPDB Length = 364 Score = 80.1 bits (196), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 69/290 (23%), Positives = 121/290 (41%), Gaps = 35/290 (12%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL-- 249 +GKG +G VC+ T + A KK+ K + L E ++L ++ +V++ Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKR-TLREIKLLRHMDHENIVAIRD 96 Query: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 ++A V D H E ++ +I GL+ +H +++ Sbjct: 97 IIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 156 Query: 310 RDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER-YTFSPDW 368 RDLKP N+LL+ + ++I D GLA E + V T Y APE++ N YT + D Sbjct: 157 RDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDV 216 Query: 369 WALGCLLYEMIAGQSPFQQRKK-------------------KIKREEVERLVKEVP---- 405 W++GC+ E++ + F R + E +R ++++P Sbjct: 217 WSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPR 276 Query: 406 EEYSERF---SPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 + +++F P A L ++L DP R+ A HP L+ Sbjct: 277 QSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALA-----HPYLNSLH 321 >3ALO-A nrPDB Length = 327 Score = 80.1 bits (196), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 62/268 (23%), Positives = 123/268 (45%), Gaps = 19/268 (7%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 +G+G +G V + +G++ A K++ + + +++ + + ++ ++ + ++V Sbjct: 30 IGRGAYGSVNKMVHKPSGQIMAVKRI-RSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYG 88 Query: 252 AYETKDALCLVLTLMNGGDLKFH--IYHMGQAGFPEARAVFYAAEICCGLEDLHRE-RIV 308 A + + + LM+ KF+ +Y + PE L L +I+ Sbjct: 89 ALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKII 148 Query: 309 YRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVV----KNERYTF 364 +RD+KP NILLD G+I++ D G++ + + G YMAPE + + Y Sbjct: 149 HRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDV 208 Query: 365 SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE----RFSPQARSLC 420 D W+LG LYE+ G+ P+ + +++ ++VK P + S FSP + Sbjct: 209 RSDVWSLGITLYELATGRFPYPKWNSVF--DQLTQVVKGDPPQLSNSEEREFSPSFINFV 266 Query: 421 SQLLCKDPAERLGCRGGSAREVKEHPLF 448 + L KD ++R +E+ +HP Sbjct: 267 NLCLTKDESKR-----PKYKELLKHPFI 289 >5L2Q-C nrPDB Length = 320 Score = 80.1 bits (196), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 62/197 (31%), Positives = 95/197 (48%), Gaps = 23/197 (11%) Query: 254 ETKDALCLVLTLMNGGD--------LKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 + K +CLVL + D + Y + + E V ++ +E LH++ Sbjct: 113 KMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSERETVVIFYDVVRVVEALHQK 172 Query: 306 RIVYRDLKPENILLDDHGH-IRISDLGLAVH-VPEGQTIKGRVGTVGYMAPEVVKNERYT 363 IV+RDLK N++L+ H I I++ L H V EG +K + G+ Y++P+V+ Y Sbjct: 173 NIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYR 232 Query: 364 FSP-DWWALGCLLYEMIAGQSPF-----QQRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 P D WALG +L+ M+ GQ PF Q+ +KIK E +PE+ R S Sbjct: 233 GKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEY-----TIPED--GRVSENTV 285 Query: 418 SLCSQLLCKDPAERLGC 434 L +LL DP +RL Sbjct: 286 CLIRKLLVLDPQQRLAA 302 >5TOS-A nrPDB Length = 395 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 72/230 (31%), Positives = 108/230 (46%), Gaps = 22/230 (9%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVR---------ATGKMYACKKLEKKRIKKRKG 227 E + T+N FR V+G+GGFG V + TG + A KKL ++ + G Sbjct: 59 ELKLATRN-FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ---G 114 Query: 228 EAMALNEKQILEKVNSRFVVSL-AYAYETKDALCLVLTLMNGGDLKFHIYHMGQ--AGFP 284 L E L +++ +V L Y E + L LV M G L+ H++ G P Sbjct: 115 HREWLTEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLP 173 Query: 285 EARAVFYAAEICCGLEDLHRE--RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT- 341 V A + GL LH + +++YRD+K NILLD + ++SD GLA P G Sbjct: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLS 233 Query: 342 -IKGRV-GTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRK 389 + RV GT GY APE + + D ++ G LL E+++G+ + Sbjct: 234 YVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNR 283 >6GU6-A nrPDB Length = 302 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 75/296 (25%), Positives = 135/296 (45%), Gaps = 49/296 (16%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 +G+G +G V + + TG++ A KK+ + ++ + A+ E +L+++ +VSL Sbjct: 15 IGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEEGVPSTAIREISLLKELRHPNIVSLQD 73 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAV-FYAAEICCGLEDLHRERIVYR 310 L L+ ++ DLK ++ + + ++ V Y +I G+ H R+++R Sbjct: 74 VLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHR 132 Query: 311 DLKPENILLDDHGHIRISDLGL--AVHVPEGQTIKGRVGTVGYMAPEV-VKNERYTFSPD 367 DLKP+N+L+DD G I+++D GL A +P + V T+ Y +PEV + + RY+ D Sbjct: 133 DLKPQNLLIDDKGTIKLADFGLARAFGIPI-RVYTHEVVTLWYRSPEVLLGSARYSTPVD 191 Query: 368 WWALGCLLYEMIAGQSPFQQRKKKIKR----------------EEVERLVKEVPEEYSER 411 W++G + E+ A + P +I + EVE L ++Y Sbjct: 192 IWSIGTIFAEL-ATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL-----QDYKNT 245 Query: 412 F---------------SPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 F L S++L DPA+R+ S + HP F L+ Sbjct: 246 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI-----SGKMALNHPYFNDLD 296 >6CTH-A nrPDB Length = 309 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 67/237 (28%), Positives = 110/237 (46%), Gaps = 13/237 (5%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 E VT N F LG+GGFG V +R + A KK+ + ++G +E + Sbjct: 9 ELAKVTSN-FNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRA---SKQGIKEYASEVK 64 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 I+ ++ + +V L + L LV M G L HI+ G++ ++ Sbjct: 65 IISRLRHKNLVKLIGWCHERGELMLVYEFMANGSLDSHIFK-GKSLLTWEVRYRIVKDLA 123 Query: 297 CGLEDLHRER---IVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRV--GTVGY 351 L LH E +++RD+K NI+LD + ++ D GLA V + +K + GTVGY Sbjct: 124 SALLYLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGY 183 Query: 352 MAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEY 408 MAPE + + + + D ++ G + E+ +G+ + K + E LV V E Y Sbjct: 184 MAPECLSSGKASKESDVYSFGVVALEIASGRRSIEP---KFEESEALLLVPWVWESY 237 >1NY3-A nrPDB Length = 400 Score = 79.0 bits (193), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 69/264 (26%), Positives = 114/264 (43%), Gaps = 15/264 (5%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 +VLG G G+V + T + +A K L+ +R+ E + Q V R V Sbjct: 68 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE-LHWRASQCPHIV--RIVDVY 124 Query: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 Y + L +V+ ++GG+L I G F E A I ++ LH I + Sbjct: 125 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 184 Query: 310 RDLKPENILLDD---HGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSP 366 RD+KPEN+L + ++++D G A ++ T Y+APEV+ E+Y S Sbjct: 185 RDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSC 244 Query: 367 DWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVK----EVPEEYSERFSPQARSLCSQ 422 D W+LG ++Y ++ G PF ++ ++ E P S + + L Sbjct: 245 DMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRN 304 Query: 423 LLCKDPAERLGCRGGSAREVKEHP 446 LL +P +R+ + E HP Sbjct: 305 LLKTEPTQRM-----TITEFMNHP 323 >3KA0-A nrPDB Length = 320 Score = 79.0 bits (193), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 69/264 (26%), Positives = 114/264 (43%), Gaps = 15/264 (5%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 +VLG G G+V + T + +A K L+ +R+ E + Q V R V Sbjct: 22 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE-LHWRASQCPHIV--RIVDVY 78 Query: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 Y + L +V+ ++GG+L I G F E A I ++ LH I + Sbjct: 79 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 138 Query: 310 RDLKPENILLDD---HGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSP 366 RD+KPEN+L + ++++D G A ++ T Y+APEV+ E+Y S Sbjct: 139 RDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVLGPEKYDKSC 198 Query: 367 DWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVK----EVPEEYSERFSPQARSLCSQ 422 D W+LG ++Y ++ G PF ++ ++ E P S + + L Sbjct: 199 DMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRN 258 Query: 423 LLCKDPAERLGCRGGSAREVKEHP 446 LL +P +R+ + E HP Sbjct: 259 LLKTEPTQRM-----TITEFMNHP 277 >2XS0-A nrPDB Length = 386 Score = 79.0 bits (193), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 55/206 (26%), Positives = 96/206 (46%), Gaps = 12/206 (5%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 ++ + +G G G VCA + A KKL + + + A E +++ VN + Sbjct: 28 YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP-FQNQTHAKRAYRELVLMKCVNHKN 86 Query: 246 VVSLAYAYETKDAL------CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 ++ L + + +L +V+ LM+ ++ + Q R + ++ CG+ Sbjct: 87 IIGLLNVFTPQKSLEEFQDVYIVMELMDA-----NLCQVIQMELDHERMSYLLYQMLCGI 141 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359 + LH I++RDLKP NI++ ++I D GLA + V T Y APEV+ Sbjct: 142 KHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPFVVTRYYRAPEVILG 201 Query: 360 ERYTFSPDWWALGCLLYEMIAGQSPF 385 Y + D W++GC++ EMI G F Sbjct: 202 MGYKENVDIWSVGCIMGEMIKGGVLF 227 >2OZA-A nrPDB Length = 356 Score = 79.0 bits (193), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 69/264 (26%), Positives = 114/264 (43%), Gaps = 15/264 (5%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 +VLG G G+V + T + +A K L+ +R+ E + Q V R V Sbjct: 24 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE-LHWRASQCPHIV--RIVDVY 80 Query: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 Y + L +V+ ++GG+L I G F E A I ++ LH I + Sbjct: 81 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 140 Query: 310 RDLKPENILLDD---HGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSP 366 RD+KPEN+L + ++++D G A ++ T Y+APEV+ E+Y S Sbjct: 141 RDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSC 200 Query: 367 DWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVK----EVPEEYSERFSPQARSLCSQ 422 D W+LG ++Y ++ G PF ++ ++ E P S + + L Sbjct: 201 DMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRN 260 Query: 423 LLCKDPAERLGCRGGSAREVKEHP 446 LL +P +R+ + E HP Sbjct: 261 LLKTEPTQRM-----TITEFMNHP 279 >5VD3-A nrPDB Length = 311 Score = 79.0 bits (193), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 72/256 (28%), Positives = 114/256 (44%), Gaps = 22/256 (8%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 + +F++ LG G +GEV + + G++YA K+ + K A L E EKV Sbjct: 56 QQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKR-SMSPFRGPKDRARKLAEVGSHEKVG 114 Query: 243 SR-FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 V L A+E L L T + G L+ H G A PEA+ Y + L Sbjct: 115 QHPCCVRLEQAWEEGGILYLQ-TELCGPSLQQHCEAWG-ASLPEAQVWGYLRDTLLALAH 172 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER 361 LH + +V+ D+KP NI L G ++ D GL V + + + G YMAPE+++ Sbjct: 173 LHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGS- 231 Query: 362 YTFSPDWWALGCLLYEMIA------GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQ 415 Y + D ++LG + E+ G +QQ ++ +P E++ S + Sbjct: 232 YGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGY-----------LPPEFTAGLSSE 280 Query: 416 ARSLCSQLLCKDPAER 431 RS+ +L DP R Sbjct: 281 LRSVLVMMLEPDPKLR 296 >4IDT-A nrPDB Length = 356 Score = 78.6 bits (192), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 64/203 (31%), Positives = 95/203 (46%), Gaps = 17/203 (8%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 LG+G FGEV + + TG + C +KK + E E + S +V L Sbjct: 82 LGRGSFGEVHRMEDKQTG--FQCA------VKKVRLEVFRAEELMACAGLTSPRIVPLYG 133 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 A + + + L+ GG L + Q PE RA++Y + GLE LH RI++ D Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLVKE--QGCLPEDRALYYLGQALEGLEYLHSRRILHGD 191 Query: 312 LKPENILLDDHG-HIRISDLGLAVHV-PEG---QTIKGRV--GTVGYMAPEVVKNERYTF 364 +K +N+LL G H + D G AV + P+G + G GT +MAPEVV Sbjct: 192 VKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCDA 251 Query: 365 SPDWWALGCLLYEMIAGQSPFQQ 387 D W+ C++ M+ G P+ Q Sbjct: 252 KVDVWSSCCMMLHMLNGCHPWTQ 274 >5VO2-A nrPDB Length = 300 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 40/129 (31%), Positives = 72/129 (55%), Gaps = 6/129 (4%) Query: 260 CLVLTLMNGGDLKFHIYHMGQAGFPEARAVF--YAAEICCGLEDLHRERIVYRDLKPENI 317 C+++ G L Y + +AG P ++ ++ I G+ LH +I++RDLK N+ Sbjct: 76 CILMEFCAQGQL----YEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNM 131 Query: 318 LLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYE 377 L+ ++ISD G + + + T GTV +MAPEV++NE + D W+ G +L+E Sbjct: 132 LITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWE 191 Query: 378 MIAGQSPFQ 386 ++ G+ P++ Sbjct: 192 LLTGEIPYK 200 >1G3N-A nrPDB Length = 326 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 73/296 (24%), Positives = 122/296 (41%), Gaps = 47/296 (15%) Query: 192 LGKGGFGEVC-ACQVRATGKMYACKKLEKKRIKKRKGE----AMALNEKQILEKVNS--- 243 +G+G +G+V A ++ G+ A K R++ + GE + E +L + + Sbjct: 19 IGEGAYGKVFKARDLKNGGRFVALK-----RVRVQTGEEGMPLSTIREVAVLRHLETFEH 73 Query: 244 -----RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 F V + + L LV ++ DL ++ + + G P ++ G Sbjct: 74 PNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRG 132 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVK 358 L+ LH R+V+RDLKP+NIL+ G I+++D GLA + V T+ Y APEV+ Sbjct: 133 LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLL 192 Query: 359 NERYTFSPDWWALGCLLYEM------IAGQSPFQQ-----------------RKKKIKRE 395 Y D W++GC+ EM G S Q R + R+ Sbjct: 193 QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQ 252 Query: 396 EVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 + E++ + L + L +PA+R+ SA HP F+ L Sbjct: 253 AFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI-----SAYSALSHPYFQDL 303 >5TUR-A nrPDB Length = 404 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 92/338 (27%), Positives = 149/338 (44%), Gaps = 59/338 (17%) Query: 137 PCKD------LFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYR 190 PC D L ++ L H L AP D ++ + K E++P+ QY+ Sbjct: 83 PCADILEVGMLLSKINSLAH--LRAAPCND----LHATKLAPGK--EKEPLES----QYQ 130 Query: 191 V---LGKGGFGEVCACQVRATGKMYACKKLEKKRIKK----RKGEAMALNEKQILEKVNS 243 V LG GGFG V + + A K +EK RI G + + E +L+KV+S Sbjct: 131 VGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM-EVVLLKKVSS 189 Query: 244 RF--VVSLAYAYETKDALCLVLTLMNG-GDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 F V+ L +E D+ L+L DL I G AR+ F+ ++ + Sbjct: 190 GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW--QVLEAVR 247 Query: 301 DLHRERIVYRDLKPENILLD-DHGHIRISDLGLAVHVPEGQTIKGRV-----GTVGYMAP 354 H +++RD+K ENIL+D + G +++ D G G +K V GT Y P Sbjct: 248 HCHNCGVLHRDIKDENILIDLNRGELKLIDFG------SGALLKDTVYTDFDGTRVYSPP 301 Query: 355 EVVKNERYTF-SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFS 413 E ++ RY S W+LG LLY+M+ G PF+ ++ I+ + + +R S Sbjct: 302 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVF----------FRQRVS 351 Query: 414 PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 + + L L P++R + E++ HP + + Sbjct: 352 SECQHLIRWCLALRPSDR-----PTFEEIQNHPWMQDV 384 >2XNP-A nrPDB Length = 279 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 68/269 (25%), Positives = 122/269 (45%), Gaps = 21/269 (7%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLA 250 +G G +G + ++ GK+ K+L+ + + + + M ++E +L ++ +V Sbjct: 13 TIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQ-MLVSEVNLLRELKHPNIVRYY 71 Query: 251 --YAYETKDALCLVLTLMNGGDLKFHIYHMGQAG--FPEARAVFYAAEICCGLEDLHR-- 304 T L +V+ GGDL I + E + ++ L++ HR Sbjct: 72 DRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRS 131 Query: 305 ---ERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI-KGRVGTVGYMAPEVVKNE 360 +++RDLKP N+ LD ++++ D GLA + + K VGT YM+PE + Sbjct: 132 DGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRM 191 Query: 361 RYTFSPDWWALGCLLYEMIAGQSPFQQ-RKKKIKREEVERLVKEVPEEYSERFSPQARSL 419 Y D W+LGCLLYE+ A PF +K++ + E + +P YS+ + + Sbjct: 192 SYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELN----EI 247 Query: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLF 448 +++L R S E+ E+PL Sbjct: 248 ITRMLNLKDYHR-----PSVEEILENPLI 271 >4RC3-A nrPDB Length = 289 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 82/300 (27%), Positives = 133/300 (44%), Gaps = 41/300 (13%) Query: 188 QYRV---LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKR----KGEAMALNEKQILEK 240 QY+V LG GGFG V + + A K +EK RI G + + E +L+K Sbjct: 13 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM-EVVLLKK 71 Query: 241 VNSRF--VVSLAYAYETKDALCLVLTLMNG-GDLKFHIYHMGQAGFPEARAVFYAAEICC 297 V+S F V+ L +E D+ L+L DL I G AR+ F+ ++ Sbjct: 72 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW--QVLE 129 Query: 298 GLEDLHRERIVYRDLKPENILLD-DHGHIRISDLGLAVHVPEGQTIKGRV-----GTVGY 351 + H +++RD+K ENIL+D + G +++ D G G +K V GT Y Sbjct: 130 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG------SGALLKDTVYTDFDGTRVY 183 Query: 352 MAPEVVKNERYTF-SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE 410 PE ++ RY S W+LG LLY+M+ G PF+ ++ I+ + + + Sbjct: 184 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVF----------FRQ 233 Query: 411 RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQ 470 R S + + L L P++R + E++ HP + + + A + P P Sbjct: 234 RVSSECQHLIRWCLALRPSDR-----PTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPS 288 >4GS6-A nrPDB Length = 315 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 71/254 (27%), Positives = 121/254 (47%), Gaps = 33/254 (12%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLA 250 V+G+G FG VC + RA K A K++E + +RK + L + L +VN +V L Sbjct: 16 VVGRGAFGVVCKAKWRA--KDVAIKQIESE--SERKAFIVELRQ---LSRVNHPNIVKLY 68 Query: 251 YAYETKDALCLVLTLMNGGDLKFHIYHMGQA--GFPEARAVFYAAEICCGLEDLHR---E 305 A + +CLV+ GG L +++ H + + A A+ + + G+ LH + Sbjct: 69 GA--CLNPVCLVMEYAEGGSL-YNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPK 125 Query: 306 RIVYRDLKPENILLDDHGHI-RISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTF 364 +++RDLKP N+LL G + +I D G A + T G+ +MAPEV + Y+ Sbjct: 126 ALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMT--NNKGSAAWMAPEVFEGSNYSE 183 Query: 365 SPDWWALGCLLYEMIAGQSPFQQRKK-------KIKREEVERLVKEVPEEYSERFSPQAR 417 D ++ G +L+E+I + PF + + L+K +P+ Sbjct: 184 KCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKP--------IE 235 Query: 418 SLCSQLLCKDPAER 431 SL ++ KDP++R Sbjct: 236 SLMTRCWSKDPSQR 249 >2A1A-B nrPDB Length = 284 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 66/265 (24%), Positives = 120/265 (45%), Gaps = 37/265 (13%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 F++ ++G GGFG+V + R GK Y K+++ K A E + L K++ Sbjct: 13 FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEK-------AEREVKALAKLDHVN 65 Query: 246 VV-------SLAYAYETKDA---------LCLVLTLMNGGDLKFHIYHMGQAGFPEARAV 289 +V Y ET L + + + G L+ I + A+ Sbjct: 66 IVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLAL 125 Query: 290 FYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVP-EGQTIKGRVGT 348 +I G++ +H ++++ RDLKP NI L D ++I D GL + +G+ + + GT Sbjct: 126 ELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSK-GT 184 Query: 349 VGYMAPEVVKNERYTFSPDWWALGCLLYEMI-AGQSPFQQRKKKIKREEVERLVKEVPEE 407 + YM+PE + ++ Y D +ALG +L E++ + F E + ++ + Sbjct: 185 LRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAF----------ETSKFFTDLRDG 234 Query: 408 -YSERFSPQARSLCSQLLCKDPAER 431 S+ F + ++L +LL K P +R Sbjct: 235 IISDIFDKKEKTLLQKLLSKKPEDR 259 >4OLI-A nrPDB Length = 645 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 80/291 (27%), Positives = 130/291 (44%), Gaps = 47/291 (16%) Query: 119 PEVPRQLVTNCTQRLEQGPC-----KDLFQELTRLT----HEYLSVAPFADYLDSIYFNR 169 P P QL T +Q L P + + ++LTRL + L+V P + D F+ Sbjct: 294 PSCP-QLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFH- 351 Query: 170 FLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCAC----QVRATGKMYACKKLEKK-RIKK 224 K ++ R LG+G FG+V TG+M A K L+ + Sbjct: 352 -------------KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQH 398 Query: 225 RKGEAMALNEKQILEKVNSRFVVSLAYAYETK--DALCLVLTLMNGGDLKFHIYHMGQAG 282 R G E IL + ++ E + +L LV+ + G L+ + + + Sbjct: 399 RSGWK---QEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDY---LPRHS 452 Query: 283 FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI 342 A+ + +A +IC G+ LH + ++R+L N+LLD+ ++I D GLA VPEG Sbjct: 453 IGLAQLLLFAQQICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEY 512 Query: 343 KGRV-----GTVGYMAPEVVKNERYTFSPDWWALGCLLYEMI----AGQSP 384 RV V + APE +K ++ ++ D W+ G LYE++ + QSP Sbjct: 513 Y-RVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSP 562 >4AGU-A nrPDB Length = 311 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 58/196 (29%), Positives = 94/196 (47%), Gaps = 13/196 (6%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKL----EKKRIKKRKGEAMALNEKQILEKVNSRFVV 247 +G+G +G V C+ R TG++ A KK + IKK +AL E ++L+++ +V Sbjct: 11 IGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKK-----IALREIRMLKQLKHPNLV 65 Query: 248 SLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERI 307 +L + K L LV + L H Q G PE + + H+ Sbjct: 66 NLLEVFRRKRRLHLVFEYCDHTVL--HELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNC 123 Query: 308 VYRDLKPENILLDDHGHIRISDLGLA-VHVPEGQTIKGRVGTVGYMAPE-VVKNERYTFS 365 ++RD+KPENIL+ H I++ D G A + V T Y +PE +V + +Y Sbjct: 124 IHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDTQYGPP 183 Query: 366 PDWWALGCLLYEMIAG 381 D WA+GC+ E+++G Sbjct: 184 VDVWAIGCVFAELLSG 199 >4QNY-A nrPDB Length = 354 Score = 76.6 bits (187), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 68/298 (22%), Positives = 132/298 (44%), Gaps = 43/298 (14%) Query: 190 RVLGKGGFGEVC-ACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVS 248 R++G G +G V A ++ ++ A K++ K+ ++ L E ++L N ++ Sbjct: 26 RIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFNDDNIIG 85 Query: 249 LAYAY-----ETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 L E D +V+ +M DLK + GQ EA F+ + L +H Sbjct: 86 LRNILTPEDPENFDHFYIVMDIMET-DLK-QVLRSGQE-LTEAHIQFFIYQALRALHIIH 142 Query: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAV-HVPEGQTIKGRVGTVGYMAPEVVKNER- 361 +++RD+ P NIL++ + ++I D GLA +G+ + V Y APE+V ++ Sbjct: 143 SAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPELVMEDKD 202 Query: 362 YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEE-------------- 407 Y+ D W +GC+L E++ + FQ + + + +++ ++ EE Sbjct: 203 YSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSSAAQKYL 262 Query: 408 ----------YSERF---SPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 + +R+ SP+A L +L +P R+ + + HP ++L+ Sbjct: 263 KKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRI-----TVLQAMRHPFLEQLH 315 >3RAW-A nrPDB Length = 381 Score = 76.6 bits (187), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 69/264 (26%), Positives = 110/264 (41%), Gaps = 33/264 (12%) Query: 175 WL-ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALN 233 WL ER + N LG+G FG+V C A GK K+ + K R+ + +N Sbjct: 48 WLQERYEIVGN-------LGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEIN 100 Query: 234 E-KQILEK--VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVF 290 K+I EK N V ++ + +C+ L+ +F + +P Sbjct: 101 VLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEF-LKENNFQPYPLPHVRH 159 Query: 291 YAAEICCGLEDLHRERIVYRDLKPENILL---------DDH----------GHIRISDLG 331 A ++C L LH ++ + DLKPENIL ++H IR++D G Sbjct: 160 MAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFG 219 Query: 332 LAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKK 391 A E T V T Y PEV+ + D W++GC+L+E G + FQ + + Sbjct: 220 SATFDHEHHTTI--VATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENR 277 Query: 392 IKREEVERLVKEVPEEYSERFSPQ 415 +E+++ +P R Q Sbjct: 278 EHLVMMEKILGPIPSHMIHRTRKQ 301 >4E93-A nrPDB Length = 377 Score = 76.6 bits (187), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 59/212 (27%), Positives = 98/212 (46%), Gaps = 7/212 (3%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 +G+G FGEV + ++RA + A K + K A L E +IL++ + +V L Sbjct: 122 IGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLK--AKFLQEARILKQYSHPNIVRLIG 179 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 K + +V+ L+ GGD + G A + + G+E L + ++RD Sbjct: 180 VCTQKQPIYIVMELVQGGDFLTFLRTEG-ARLRVKTLLQMVGDAAAGMEYLESKCCIHRD 238 Query: 312 LKPENILLDDHGHIRISDLGLAVHVPEGQTIKG---RVGTVGYMAPEVVKNERYTFSPDW 368 L N L+ + ++ISD G++ +G R V + APE + RY+ D Sbjct: 239 LAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDV 298 Query: 369 WALGCLLYEMIA-GQSPFQQRKKKIKREEVER 399 W+ G LL+E + G SP+ + RE VE+ Sbjct: 299 WSFGILLWETFSLGASPYPNLSNQQTREFVEK 330 >3BGP-A nrPDB Length = 333 Score = 76.6 bits (187), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 82/300 (27%), Positives = 133/300 (44%), Gaps = 41/300 (13%) Query: 188 QYRV---LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKR----KGEAMALNEKQILEK 240 QY+V LG GGFG V + + A K +EK RI G + + E +L+K Sbjct: 57 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM-EVVLLKK 115 Query: 241 VNSRF--VVSLAYAYETKDALCLVLTLMNG-GDLKFHIYHMGQAGFPEARAVFYAAEICC 297 V+S F V+ L +E D+ L+L DL I G AR+ F+ ++ Sbjct: 116 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW--QVLE 173 Query: 298 GLEDLHRERIVYRDLKPENILLD-DHGHIRISDLGLAVHVPEGQTIKGRV-----GTVGY 351 + H +++RD+K ENIL+D + G +++ D G G +K V GT Y Sbjct: 174 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG------SGALLKDTVYTDFDGTRVY 227 Query: 352 MAPEVVKNERYTF-SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE 410 PE ++ RY S W+LG LLY+M+ G PF+ ++ I+ + + + Sbjct: 228 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVF----------FRQ 277 Query: 411 RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQ 470 R S + + L L P++R + E++ HP + + + A + P P Sbjct: 278 RVSSECQHLIRWCLALRPSDR-----PTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPS 332 >4E7W-A nrPDB Length = 394 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 79/296 (26%), Positives = 131/296 (44%), Gaps = 47/296 (15%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 +V+G G FG V ++ + ++ K L+ KR K R E QI+ V VV L Sbjct: 46 KVIGNGSFGVVFQAKLVESDEVAIKKVLQDKRFKNR--------ELQIMRIVKHPNVVDL 97 Query: 250 -AYAY---ETKDALCLVLTLMNGGDLKFHI---YHMGQAGFPEARAVFYAAEICCGLEDL 302 A+ Y + KD + L L L + + Y + P Y ++ L + Sbjct: 98 KAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAYI 157 Query: 303 HRERIVYRDLKPENILLD-DHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVV-KNE 360 H I +RD+KP+N+LLD G +++ D G A + G+ + + Y APE++ Sbjct: 158 HSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPELIFGAT 217 Query: 361 RYTFSPDWWALGCLLYEMIAGQ--------------------SPFQQRKKKIKREEVERL 400 YT + D W+ GC++ E++ GQ +P +++ K + +E Sbjct: 218 NYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNYMEHK 277 Query: 401 VKEV-PEEYSERFSPQ----ARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 ++ P +S+ F P+ A L S+LL P+ RL +A E HP F +L Sbjct: 278 FPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARL-----TAIEALCHPFFDEL 328 >2H34-A nrPDB Length = 309 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 61/248 (24%), Positives = 107/248 (43%), Gaps = 5/248 (2%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 +R R++G+GG G+V + ++ A K + + E + ++ Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 VV + E L + + L+NG DL + G P RAV +I L+ H Sbjct: 96 VVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPP--RAVAIVRQIGSALDAAHAA 153 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIK--GRVGTVGYMAPEVVKNERYT 363 +RD+KPENIL+ + D G+A + + + VGT+ YMAPE T Sbjct: 154 GATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSESHAT 213 Query: 364 FSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQL 423 + D +AL C+LYE + G P+Q + + + + + P ++ ++ Sbjct: 214 YRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPR-PSTVRPGIPVAFDAVIARG 272 Query: 424 LCKDPAER 431 + K+P +R Sbjct: 273 MAKNPEDR 280 >6DBM-A nrPDB Length = 318 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 65/218 (29%), Positives = 103/218 (47%), Gaps = 23/218 (10%) Query: 183 KNTFRQYRVLGKGGFGEVCAC----QVRATGKMYACKKLEKKR-IKKRKGEAMALNEKQI 237 K ++ R LG+G FG+V TG+M A K L+ + R G E I Sbjct: 30 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWK---QEIDI 86 Query: 238 LEKVNSRFVVSLAYAYETKDA--LCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEI 295 L + ++ E A L LV+ + G L+ + + + A+ + +A +I Sbjct: 87 LRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDY---LPRHSIGLAQLLLFAQQI 143 Query: 296 CCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRV-----GTVG 350 C G+ LH + ++RDL N+LLD+ ++I D GLA VPEG RV V Sbjct: 144 CEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYY-RVREDGDSPVF 202 Query: 351 YMAPEVVKNERYTFSPDWWALGCLLYEMI----AGQSP 384 + APE +K ++ ++ D W+ G LYE++ + QSP Sbjct: 203 WYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSP 240 >5D7A-A nrPDB Length = 308 Score = 76.3 bits (186), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 67/284 (23%), Positives = 124/284 (43%), Gaps = 38/284 (13%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKL-----EKKRIKKRKGEAMALNEKQILEK 240 F ++G G +G+V + TG++ A K + E++ IK+ E +L+K Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQ---------EINMLKK 69 Query: 241 VNSRFVVSLAYAYETK-------DALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAA 293 + ++ Y K D L LV+ G + I + E + Sbjct: 70 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 129 Query: 294 EICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR---VGTVG 350 EI GL LH+ ++++RD+K +N+LL ++ +++ D G++ + +T+ R +GT Sbjct: 130 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQL--DRTVGRRNTFIGTPY 187 Query: 351 YMAPEVVK-----NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVP 405 +MAPEV+ + Y F D W+LG EM G P + R P Sbjct: 188 WMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPR--NPAP 245 Query: 406 EEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFK 449 S+++S + +S L K+ ++R + ++ +HP + Sbjct: 246 RLKSKKWSKKFQSFIESCLVKNHSQR-----PATEQLMKHPFIR 284 >4G3E-A nrPDB Length = 352 Score = 75.9 bits (185), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 68/220 (30%), Positives = 103/220 (46%), Gaps = 27/220 (12%) Query: 175 WLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNE 234 W+ QP RV G+G FGEV + + TG + C +KK + E + E Sbjct: 75 WMTHQP---------RV-GRGSFGEVHRMKDKQTG--FQCA------VKKVRLEVFRVEE 116 Query: 235 KQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAE 294 ++S +V L A + + + L+ GG L I MG PE RA++Y + Sbjct: 117 LVACAGLSSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQMGC--LPEDRALYYLGQ 174 Query: 295 ICCGLEDLHRERIVYRDLKPENILLDDHG-HIRISDLGLAVHV-PEG---QTIKGRV--G 347 GLE LH RI++ D+K +N+LL G + D G A+ + P+G + G G Sbjct: 175 ALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPG 234 Query: 348 TVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQ 387 T +MAPEVV + D W+ C++ M+ G P+ Q Sbjct: 235 TETHMAPEVVMGKPCDAKVDIWSSCCMMLHMLNGCHPWTQ 274 >1ZXE-A nrPDB Length = 303 Score = 75.9 bits (185), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 67/278 (24%), Positives = 122/278 (43%), Gaps = 34/278 (12%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 F + VLG+G FG+V + + YA KK+ K + L+E +L +N ++ Sbjct: 8 FEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKL----STILSEVMLLASLNHQY 63 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKF---------HIYHMGQA-GFPEARAVFYAA-- 293 VV A+ + +T + F +Y + + + R ++ Sbjct: 64 VVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFR 123 Query: 294 EICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVP--------EGQTIKGR 345 +I L +H + I++R+LKP NI +D+ +++I D GLA +V + Q + G Sbjct: 124 QILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGS 183 Query: 346 -------VGTVGYMAPEVVKNE-RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEV 397 +GT Y+A EV+ Y D ++LG + +EMI S +R +K+ + Sbjct: 184 SDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIYPFSTGMERVNILKK--L 241 Query: 398 ERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCR 435 + E P ++ + + + L+ DP +R G R Sbjct: 242 RSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGAR 279 >3LLT-A nrPDB Length = 360 Score = 75.9 bits (185), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 72/278 (25%), Positives = 112/278 (40%), Gaps = 41/278 (14%) Query: 163 DSIYF---NRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEK 219 +++YF + + + W ++ + N F R +G G FG V CQ K YA K + Sbjct: 12 ENLYFQGDDEIVHFSW-KKGMLLNNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVV-- 68 Query: 220 KRIKKRKGEAMALNEKQILEKVNSRFV-----VSLAYAYETKDALCLVLTLMNGGDLKFH 274 + IKK A E IL+K+ + + V + D +CL+ + G L Sbjct: 69 RNIKKYTRSAKI--EADILKKIQNDDINNNNIVKYHGKFMYYDHMCLIFEPL-GPSLYEI 125 Query: 275 IYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDD------------- 321 I GF Y EI L L + + + DLKPENILLDD Sbjct: 126 ITRNNYNGFHIEDIKLYCIEILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRV 185 Query: 322 ------------HGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWW 369 I++ D G A + + T Y APEV+ N + S D W Sbjct: 186 TDGKKIQIYRTKSTGIKLIDFGCATFKSDYHG--SIINTRQYRAPEVILNLGWDVSSDMW 243 Query: 370 ALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEE 407 + GC+L E+ G F+ + +E +++ +P+ Sbjct: 244 SFGCVLAELYTGSLLFRTHEHMEHLAMMESIIQPIPKN 281 >5B2L-A nrPDB Length = 324 Score = 75.9 bits (185), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 60/255 (23%), Positives = 112/255 (43%), Gaps = 27/255 (10%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 +G G G+V + R TG + A K++ ++ K + + + ++ +L+ + ++V Sbjct: 25 MGSGTCGQVWKMRFRKTGHVIAVKQM-RRSGNKEENKRILMDLDVVLKSHDCPYIVQCFG 83 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYH--------MGQAGFPEARAVFYAAEICCGLEDLH 303 + T + + + LM K +G+ +A++Y E Sbjct: 84 TFITNTDVFIAMELMGTSAEKLKKRMQGPIPERILGKMTVAIVKALYYLKE--------- 134 Query: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVV-----K 358 + +++RD+KP NILLD+ G I++ D G++ + + + G YMAPE + Sbjct: 135 KHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPT 194 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSER--FSPQA 416 Y D W+LG L E+ GQ P++ K E + ++++E P FS Sbjct: 195 KPDYDIRADVWSLGISLVELATGQFPYKNCKTDF--EVLTKVLQEEPPLLPGHMGFSGDF 252 Query: 417 RSLCSQLLCKDPAER 431 +S L KD +R Sbjct: 253 QSFVKDCLTKDHRKR 267 >6GVJ-A nrPDB Length = 429 Score = 75.5 bits (184), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 61/230 (26%), Positives = 106/230 (46%), Gaps = 31/230 (13%) Query: 187 RQYRVL---GKGGFGEVCACQVRATGKMYACKKL-----EKKRIKKRKGEAMALNEKQIL 238 R Y +L G GG +V + ++YA K + + + + + E LN+ Q Sbjct: 144 RIYSILKQIGSGGSSKVFQV-LNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQ-- 200 Query: 239 EKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 +S ++ L Y YE D + +M G++ + + + Y + Sbjct: 201 --QHSDKIIRL-YDYEITDQY--IYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEA 255 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV-PEGQTI--KGRVGTVGYMAPE 355 + +H+ IV+ DLKP N L+ D G +++ D G+A + P+ ++ +VGTV YM PE Sbjct: 256 VHTIHQHGIVHSDLKPANFLIVD-GMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPE 314 Query: 356 VVKNERYT-----------FSPDWWALGCLLYEMIAGQSPFQQRKKKIKR 394 +K+ + D W+LGC+LY M G++PFQQ +I + Sbjct: 315 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISK 364 >4NEU-A nrPDB Length = 333 Score = 75.5 bits (184), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 65/218 (29%), Positives = 103/218 (47%), Gaps = 20/218 (9%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 F + L GGFG+V C R G M K + K EA+ L E +++ ++ Sbjct: 26 FLESAELDSGGFGKVSLCFHRTQGLM-IMKTVYKGPNCIEHNEAL-LEEAKMMNRLRHSR 83 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 VV L + LV+ M G+L H+ + P + EI G+ LH + Sbjct: 84 VVKLLGVIIEEGKYSLVMEYMEKGNL-MHVLK-AEMSTPLSVKGRIILEIIEGMCYLHGK 141 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLA-------VHVPEGQ-------TIKGRVGTVGY 351 ++++DLKPENIL+D+ HI+I+DLGLA ++ E T K GT+ Y Sbjct: 142 GVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYY 201 Query: 352 MAPEVVK--NERYTFSPDWWALGCLLYEMIAGQSPFQQ 387 MAPE + N + T D ++ +L+ + A + P++ Sbjct: 202 MAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYEN 239 >6E2O-A nrPDB Length = 295 Score = 75.1 bits (183), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 71/253 (28%), Positives = 125/253 (49%), Gaps = 23/253 (9%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK-VNSRFVVSL 249 VLGKG +G V A + + A K++ ++ + + L+E+ L K + + +V Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRY----SQPLHEEIALHKHLKHKNIVQY 84 Query: 250 AYAYETKDALCLVLTLMNGGDLKFHI-YHMGQAGFPEARAVFYAAEICCGLEDLHRERIV 308 ++ + + + + GG L + G E FY +I GL+ LH +IV Sbjct: 85 LGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIV 144 Query: 309 YRDLKPENILLDDH-GHIRISDLG----LAVHVPEGQTIKGRVGTVGYMAPEVV-KNER- 361 +RD+K +N+L++ + G ++ISD G LA P +T GT+ YMAPE++ K R Sbjct: 145 HRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETF---TGTLQYMAPEIIDKGPRG 201 Query: 362 YTFSPDWWALGCLLYEMIAGQSPFQQR---KKKIKREEVERLVKEVPEEYSERFSPQARS 418 Y + D W+LGC + EM G+ PF + + + + + ++ E+PE S +A++ Sbjct: 202 YGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPES----MSAEAKA 257 Query: 419 LCSQLLCKDPAER 431 + DP +R Sbjct: 258 FILKCFEPDPDKR 270 >3UIU-A nrPDB Length = 306 Score = 75.1 bits (183), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 67/278 (24%), Positives = 123/278 (44%), Gaps = 50/278 (17%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 F++ ++G GGFG+V + R GK Y ++++ K A E + L K++ Sbjct: 14 FKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNNEK-------AEREVKALAKLDHVN 66 Query: 246 VV-------SLAYAYETKD--------------------ALCLVLTLM--NGGDLKFHIY 276 +V Y ET D CL + + + G L+ I Sbjct: 67 IVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIE 126 Query: 277 HMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV 336 + A+ +I G++ +H +++++RDLKP NI L D ++I D GL + Sbjct: 127 KRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSL 186 Query: 337 P-EGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMI-AGQSPFQQRKKKIKR 394 +G+ + + GT+ YM+PE + ++ Y D +ALG +L E++ + F Sbjct: 187 KNDGKRTRSK-GTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAF--------- 236 Query: 395 EEVERLVKEVPEE-YSERFSPQARSLCSQLLCKDPAER 431 E + ++ + S+ F + ++L +LL K P +R Sbjct: 237 -ETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDR 273 >6FYV-A nrPDB Length = 337 Score = 75.1 bits (183), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 66/256 (25%), Positives = 107/256 (41%), Gaps = 51/256 (19%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS------- 243 LG+G FG+V C M+ K+ K + R+ A +E Q+LE +NS Sbjct: 21 TLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREA---ARSEIQVLEHLNSTDPNSVF 77 Query: 244 RFVVSLAYAYETKDALCLVLTLMN---------GGDLKFHIYHMGQAGFPEARAVFYAAE 294 R V L + ++ +C+V L+ L F I H+ Q + + Sbjct: 78 RCVQMLEW-FDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAY----------Q 126 Query: 295 ICCGLEDLHRERIVYRDLKPENILLDDHGH-------------------IRISDLGLAVH 335 IC + LH ++ + DLKPENIL + I++ D G A + Sbjct: 127 ICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATY 186 Query: 336 VPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKRE 395 E + V T Y APEV+ ++ D W++GC+L E G + FQ K Sbjct: 187 DDEHHST--LVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLA 244 Query: 396 EVERLVKEVPEEYSER 411 +ER++ +P+ ++ Sbjct: 245 MMERILGPIPQHMIQK 260 >2BUJ-A nrPDB Length = 317 Score = 75.1 bits (183), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 73/260 (28%), Positives = 111/260 (42%), Gaps = 25/260 (9%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS-RFVVSLA 250 LG+GGF V + G YA K++ + R+ + ++ N R V Sbjct: 37 LGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLFNHPNILRLVAYCL 96 Query: 251 YAYETKDALCLVLTLMNGGDLKFHIYHMGQAG--FPEARAVFYAAEICCGLEDLHRERIV 308 K L+L G L I + G E + ++ IC GLE +H + Sbjct: 97 RERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEAIHAKGYA 156 Query: 309 YRDLKPENILLDDHGHIRISDLG----LAVHVPEG-------QTIKGRVGTVGYMAPEVV 357 +RDLKP NILL D G + DLG +HV EG Q + T+ Y APE+ Sbjct: 157 HRDLKPTNILLGDEGQPVLMDLGSMNQACIHV-EGSRQALTLQDWAAQRCTISYRAPELF 215 Query: 358 KNERYTF---SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKE---VPEEYSER 411 + + D W+LGC+LY M+ G+ P+ + K + V V+ +P+ S R Sbjct: 216 SVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQ--KGDSVALAVQNQLSIPQ--SPR 271 Query: 412 FSPQARSLCSQLLCKDPAER 431 S L + ++ DP +R Sbjct: 272 HSSALWQLLNSMMTVDPHQR 291 >6EII-A nrPDB Length = 352 Score = 75.1 bits (183), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 58/195 (29%), Positives = 85/195 (43%), Gaps = 41/195 (21%) Query: 290 FYAAEICCGLEDLHRERIVYRDLKPENILLD-DHGHIRISDLGLAVHVPEGQTIKGRVGT 348 FY EI L+ H I++RD+KP N+++D +H +R+ D GLA GQ RV + Sbjct: 158 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVAS 217 Query: 349 VGYMAPEV-VKNERYTFSPDWWALGCLLYEMIAGQSPF----------QQRKKKIKREEV 397 + PE+ V + Y +S D W+LGC+L MI + PF + K + E++ Sbjct: 218 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDL 277 Query: 398 ERLVKEVPEEYSERF------------------------SPQARSLCSQLLCKDPAERLG 433 + + E RF SP+A +LL D RL Sbjct: 278 YDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL- 336 Query: 434 CRGGSAREVKEHPLF 448 +ARE EHP F Sbjct: 337 ----TAREAMEHPYF 347 >4CSV-A nrPDB Length = 275 Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 60/215 (27%), Positives = 100/215 (46%), Gaps = 11/215 (5%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 R LG G FGEV + R A K L++ + + L E QI++K+ +V L Sbjct: 17 RKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEE----FLQEAQIMKKLKHPNLVQL 72 Query: 250 AYAYETKDALCLVLT-LMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIV 308 Y TK+ ++T M+ G L ++ + AA++ G+ L + + Sbjct: 73 -YGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAYLESQNFI 131 Query: 309 YRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGT---VGYMAPEVVKNERYTFS 365 +RDL N L+ ++ ++++D GLA + E + R G + + APE + R++ Sbjct: 132 HRDLAARNCLVGENNVVKVADFGLARLINEDE-YTARAGAKFPIKWTAPEAISYNRFSIK 190 Query: 366 PDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVER 399 D WA G LL+E+ GQ P+ E+VER Sbjct: 191 SDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVER 225 >4UYA-A nrPDB Length = 340 Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 63/210 (30%), Positives = 99/210 (47%), Gaps = 22/210 (10%) Query: 191 VLGKGGFGEVCACQVRAT--GKMYACKKLEKKRIKKRKGEAMALN-EKQILEKVNSRFVV 247 ++G GGFG+V RAT G+ A K + + A ++ E ++ + ++ Sbjct: 33 LIGAGGFGQV----YRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNII 88 Query: 248 SLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRER- 306 L + LCLVL GG L + P V +A +I G+ LH E Sbjct: 89 ELRGVCLQQPHLCLVLEFARGGALN---RALAGRRIPPHVLVNWAVQIARGMLYLHEEAF 145 Query: 307 --IVYRDLKPENILL------DD--HGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 I++RDLK NILL DD + ++I+D GLA T G +MAPEV Sbjct: 146 VPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREW-HRTTKMATAGAYAWMAPEV 204 Query: 357 VKNERYTFSPDWWALGCLLYEMIAGQSPFQ 386 +K+ ++ D W+ G LL+E++ G+ P++ Sbjct: 205 IKSSLFSKGSDIWSYGVLLWELLTGEVPYR 234 >2DQ7-X nrPDB Length = 283 Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 59/222 (26%), Positives = 102/222 (45%), Gaps = 9/222 (4%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 + + + + + LG G FGEV K+ A K L+ + L E QI++K Sbjct: 6 IPRESLQLIKRLGNGQFGEVWMGTWNGNTKV-AIKTLKPGTMSPES----FLEEAQIMKK 60 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 + +V L YA +++ + +V MN G L + V AA++ G+ Sbjct: 61 LKHDKLVQL-YAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMA 119 Query: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI--KGRVGTVGYMAPEVVK 358 + R ++RDL+ NIL+ + +I+D GLA + + + +G + + APE Sbjct: 120 YIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 179 Query: 359 NERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVER 399 R+T D W+ G LL E++ G+ P+ + E+VER Sbjct: 180 YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVER 221 >4O2Z-A nrPDB Length = 377 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 57/233 (24%), Positives = 107/233 (45%), Gaps = 17/233 (7%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKL--------EKKRIKKRKGEAMALNEKQILEKV 241 ++LG G +G C+C TG+ + KK + KR+ + + + +L V Sbjct: 51 KILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREIDMMRFFHHENLLNVV 110 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 N + L Y + + + +V LM D+ ++ + E+ ++ +I GL+ Sbjct: 111 N--ILPPLKREYHSFEDVYVVTPLM---DVDMNVVLRSRQVLEESHMQYFVYQILRGLKY 165 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGL--AVHVPEGQTIKGRVGTVGYMAPE-VVK 358 LH + +RDLKP N++ + ++I D GL +V VP + + V T Y PE +++ Sbjct: 166 LHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSE-LTDYVITRWYRPPELLLE 224 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSER 411 N Y+ + D W++GC+ EM + F R + + + + + P E Sbjct: 225 NTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEH 277 >3ORP-A nrPDB Length = 311 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 64/261 (24%), Positives = 110/261 (42%), Gaps = 34/261 (13%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKK---------RIKKRKGEAMALNEKQILEKV 241 +LG GG EV + + A K L R ++ A ALN I+ Sbjct: 19 ILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPAIVA-- 76 Query: 242 NSRFVVSLAYAYETKDALC-------LVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAE 294 Y+T +A +V+ ++G L+ I H P+ RA+ A+ Sbjct: 77 ----------VYDTGEAETPAGPLPYIVMEYVDGVTLR-DIVHTEGPMTPK-RAIEVIAD 124 Query: 295 ICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPE-GQTIK---GRVGTVG 350 C L H+ I++RD+KP NI++ +++ D G+A + + G ++ +GT Sbjct: 125 ACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQ 184 Query: 351 YMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE 410 Y++PE + + D ++LGC+LYE++ G+ PF + R P E Sbjct: 185 YLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHE 244 Query: 411 RFSPQARSLCSQLLCKDPAER 431 S ++ + L K+P R Sbjct: 245 GLSADLDAVVLKALAKNPENR 265 >6FER-A nrPDB Length = 309 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 75/299 (25%), Positives = 124/299 (41%), Gaps = 45/299 (15%) Query: 192 LGKGGFGEVCACQVRATGK----------------MYACKKLEKKRIKKRKGEAMALNEK 235 LG+G FGEV C+V K + A K L K + + L E Sbjct: 17 LGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDF--LKEI 74 Query: 236 QILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHI--YHMGQAGFPEARAV---- 289 +I+ ++ ++ L T D LC++ M GDL + + + + R V Sbjct: 75 KIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTN 134 Query: 290 --FYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT--IKGR 345 F A +I G++ L V+RDL N L+ + I+I+D G++ ++ G I+GR Sbjct: 135 LKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGR 194 Query: 346 -VGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA--GQSPFQQRKKKIKREEVERLVK 402 V + +M+ E + ++T + D WA G L+E + P+ Q + Sbjct: 195 AVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSD-----------E 243 Query: 403 EVPEEYSERFSPQARS--LCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAG 459 +V E E F Q R L +C D +L R+ K P F++++ L G Sbjct: 244 QVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWR-RDTKNRPSFQEIHLLLLQQG 301 >4MD7-E nrPDB Length = 391 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 60/210 (28%), Positives = 92/210 (43%), Gaps = 43/210 (20%) Query: 290 FYAAEICCGLEDLHRERIVYRDLKPENILLD-DHGHIRISDLGLAVHVPEGQTIKGRVGT 348 FY EI L+ H I++RD+KP N+++D +H +R+ D GLA GQ RV + Sbjct: 135 FYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVAS 194 Query: 349 VGYMAPEV-VKNERYTFSPDWWALGCLLYEMIAGQSPF----------QQRKKKIKREEV 397 + PE+ V + Y +S D W+LGC+L MI + PF + K + E++ Sbjct: 195 RYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDL 254 Query: 398 ERLVKEVPEEYSERF------------------------SPQARSLCSQLLCKDPAERLG 433 + + E RF SP+A +LL D RL Sbjct: 255 YDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL- 313 Query: 434 CRGGSAREVKEHPLFKKL--NFKRLGAGML 461 +ARE EHP F + + R+G+ + Sbjct: 314 ----TAREAMEHPYFYTVVKDQARMGSSSM 339 >3HMP-A nrPDB Length = 342 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 61/230 (26%), Positives = 106/230 (46%), Gaps = 31/230 (13%) Query: 187 RQYRVL---GKGGFGEVCACQVRATGKMYACKKL-----EKKRIKKRKGEAMALNEKQIL 238 R Y +L G GG +V + ++YA K + + + + + E LN+ Q Sbjct: 56 RIYSILKQIGSGGSSKVFQV-LNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQ-- 112 Query: 239 EKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 +S ++ L Y YE D + +M G++ + + + Y + Sbjct: 113 --QHSDKIIRL-YDYEITDQY--IYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEA 167 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV-PEGQTI--KGRVGTVGYMAPE 355 + +H+ IV+ DLKP N L+ D G +++ D G+A + P+ ++ +VGTV YM PE Sbjct: 168 VHTIHQHGIVHSDLKPANFLIVD-GMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPE 226 Query: 356 VVKNERYT-----------FSPDWWALGCLLYEMIAGQSPFQQRKKKIKR 394 +K+ + D W+LGC+LY M G++PFQQ +I + Sbjct: 227 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISK 276 >4XLV-A nrPDB Length = 328 Score = 73.2 bits (178), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 74/283 (26%), Positives = 121/283 (42%), Gaps = 32/283 (11%) Query: 136 GPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKG 195 GP LF EYLS + + S+Y +W+ V++ R LG+G Sbjct: 4 GPLGPLF---ASSNPEYLSASDV--FPSSVYVPD--EWE------VSREKITLLRELGQG 50 Query: 196 GFGEVCACQVRATGKMYACKKLEKKRIKKRKG---EAMALNEKQILEKVNSRFVVSLAYA 252 FG V R K A ++ K + + LNE +++ VV L Sbjct: 51 SFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGV 110 Query: 253 YETKDALCLVLTLMNGGDLKFHIYHM-----GQAGFPEA---RAVFYAAEICCGLEDLHR 304 +V+ LM GDLK ++ + G P + AAEI G+ L+ Sbjct: 111 VSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNA 170 Query: 305 ERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI-KGRVGT--VGYMAPEVVKNER 361 ++ V+RDL N ++ ++I D G+ + E KG G V +MAPE +K+ Sbjct: 171 KKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGV 230 Query: 362 YTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKE 403 +T S D W+ G +L+E+ + + P+Q + E+V + V + Sbjct: 231 FTTSSDMWSFGVVLWEITSLAEQPYQ----GLSNEQVLKFVMD 269 >2WTK-C nrPDB Length = 305 Score = 73.2 bits (178), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 65/233 (27%), Positives = 109/233 (46%), Gaps = 19/233 (8%) Query: 226 KGEAMALNEKQILEKVNSRFVVSLAYAY--ETKDALCLVLTLMNGGDLKFHIYHMGQAGF 283 GEA E Q+L ++ + V+ L E K + +V+ G ++ + + + F Sbjct: 48 NGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCG-MQEMLDSVPEKRF 106 Query: 284 PEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGL--AVH-VPEGQ 340 P +A Y ++ GLE LH + IV++D+KP N+LL G ++IS LG+ A+H Sbjct: 107 PVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADD 166 Query: 341 TIKGRVGTVGYMAPEVVKNERYTFSP---DWWALGCLLYEMIAGQSPFQQRKKKIKREEV 397 T + G+ + PE+ N TFS D W+ G LY + G PF+ E + Sbjct: 167 TCRTSQGSPAFQPPEIA-NGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENI 225 Query: 398 ERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 + +P + P L +L +PA+R S R++++H F+K Sbjct: 226 GKGSYAIPGD----CGPPLSDLLKGMLEYEPAKRF-----SIRQIRQHSWFRK 269 >5AP3-A nrPDB Length = 313 Score = 73.2 bits (178), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 59/239 (24%), Positives = 108/239 (45%), Gaps = 28/239 (11%) Query: 175 WLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKL-----EKKRIKKRKGEA 229 + + V + + +G GG +V + ++YA K + + + + + E Sbjct: 19 YFQSMSVKGRIYSILKQIGSGGSSKVFQV-LNEKKQIYAIKYVNLEEADNQTLDSYRNEI 77 Query: 230 MALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAV 289 LN+ Q +S ++ L Y YE D + +M G++ + + + Sbjct: 78 AYLNKLQ----QHSDKIIRL-YDYEITDQY--IYMVMECGNIDLNGWLKKKKSIDPWERK 130 Query: 290 FYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV-PEGQTI--KGRV 346 Y + + +H+ IV+ DLKP N L+ D G +++ D G+A + P+ ++ +V Sbjct: 131 SYWKNMLEAVHTIHQHGIVHSDLKPANFLIVD-GMLKLIDFGIANQMQPDTTSVVKDSQV 189 Query: 347 GTVGYMAPEVVKNERYT-----------FSPDWWALGCLLYEMIAGQSPFQQRKKKIKR 394 GTV YM PE +K+ + D W+LGC+LY M G++PFQQ +I + Sbjct: 190 GTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISK 248 >2WO6-A nrPDB Length = 382 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 67/264 (25%), Positives = 121/264 (45%), Gaps = 33/264 (12%) Query: 174 KWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALN 233 KW++R + ++GKG FG+V R + A K ++ K+ + + Sbjct: 51 KWMDRYEIDS-------LIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQI---- 99 Query: 234 EKQILEKVNSR------FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQA----GF 283 E ++LE +N ++V L + ++ LCLV + L +++Y + + G Sbjct: 100 EVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM-----LSYNLYDLLRNTNFRGV 154 Query: 284 PEARAVFYAAEICCGLEDLHRER--IVYRDLKPENILLDD--HGHIRISDLGLAVHVPEG 339 +A ++C L L I++ DLKPENILL + I+I D G + + G Sbjct: 155 SLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQL--G 212 Query: 340 QTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVER 399 Q I + + Y +PEV+ Y + D W+LGC+L EM G+ F + + ++ Sbjct: 213 QRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVE 272 Query: 400 LVKEVPEEYSERFSPQARSLCSQL 423 ++ P ++ +P+AR +L Sbjct: 273 VLGIPPAHILDQ-APKARKFFEKL 295 >5WNO-A nrPDB Length = 330 Score = 72.8 bits (177), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 36/102 (35%), Positives = 57/102 (55%), Gaps = 4/102 (3%) Query: 289 VFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA---VHVPEGQTIKGR 345 V Y +I G++ L ++R+V+RDL N+L+ H+ I+D GL+ H + TIK Sbjct: 127 VLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSG 186 Query: 346 VGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQ 386 + ++A E+ YT + D WA G +E+I GQSP+Q Sbjct: 187 KVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQ 228 >3UIM-A nrPDB Length = 326 Score = 72.8 bits (177), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 57/212 (26%), Positives = 96/212 (45%), Gaps = 10/212 (4%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 V + F +LG+GGFG+V ++ A G + A K+L+++R + GE E +++ Sbjct: 27 VASDNFSNKNILGRGGFGKVYKGRL-ADGTLVAVKRLKEERTQG--GELQFQTEVEMISM 83 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFP-----EARAVFYAAEI 295 R ++ L T LV M G + + ++ P R +A Sbjct: 84 AVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARG 143 Query: 296 CCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA--VHVPEGQTIKGRVGTVGYMA 353 L D +I++RD+K NILLD+ + D GLA + + GT+G++A Sbjct: 144 LAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIA 203 Query: 354 PEVVKNERYTFSPDWWALGCLLYEMIAGQSPF 385 PE + + + D + G +L E+I GQ F Sbjct: 204 PEYLSTGKSSEKTDVFGYGVMLLELITGQRAF 235 >4X7Q-B nrPDB Length = 312 Score = 72.4 bits (176), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 70/256 (27%), Positives = 112/256 (43%), Gaps = 23/256 (8%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALN---EKQILEKVN 242 +R +LGKGGFG V A A K + + R+ + ++ E +L KV Sbjct: 33 YRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVG 92 Query: 243 S----RFVVSLAYAYETKDALCLVLTL-MNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 + V+ L +ET++ LVL + DL +I G G +R F ++ Sbjct: 93 AGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFF--GQVVA 150 Query: 298 GLEDLHRERIVYRDLKPENILLD-DHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 ++ H +V+RD+K ENIL+D G ++ D G + + GT Y PE Sbjct: 151 AIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALL-HDEPYTDFDGTRVYSPPEW 209 Query: 357 VKNERYTFSP-DWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQ 415 + +Y P W+LG LLY+M+ G PF +R ++I E+ + SP Sbjct: 210 ISRHQYHALPATVWSLGILLYDMVCGDIPF-ERDQEILEAEL---------HFPAHVSPD 259 Query: 416 ARSLCSQLLCKDPAER 431 +L + L P+ R Sbjct: 260 CCALIRRCLAPKPSSR 275 >5UNP-A nrPDB Length = 369 Score = 72.0 bits (175), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 56/240 (23%), Positives = 100/240 (41%), Gaps = 31/240 (12%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR------ 244 LG+G FG V C G K+ K K ++ + +N +LEK+N + Sbjct: 41 TLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEIN---VLEKINEKDPDNKN 97 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 V + ++ +C+ L+ F + +P + A ++C ++ LH Sbjct: 98 LCVQMFDWFDYHGHMCISFELLGLSTFDF-LKDNNYLPYPIHQVRHMAFQLCQAVKFLHD 156 Query: 305 ERIVYRDLKPENILLDDHGH-------------------IRISDLGLAVHVPEGQTIKGR 345 ++ + DLKPENIL + + +R+ D G A E + Sbjct: 157 NKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTI-- 214 Query: 346 VGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVP 405 V T Y APEV+ ++ D W++GC+++E G + FQ + +ER++ +P Sbjct: 215 VSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIP 274 >5AMN-A nrPDB Length = 299 Score = 72.0 bits (175), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 61/214 (28%), Positives = 104/214 (48%), Gaps = 21/214 (9%) Query: 190 RVLGKGGFGEVCACQV-----RATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 + LG+G FG+V RA A K L++ + L+E +L++VN Sbjct: 29 KTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDL--LSEFNVLKQVNHP 86 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG--FPEARA------VFYAAEIC 296 V+ L A L L++ G L+ + + G +P+ RA + +A +I Sbjct: 87 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISFAWQIS 146 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI----KGRVGTVGYM 352 G++ L ++V+RDL NIL+ + ++ISD GL+ V E + +GR+ V +M Sbjct: 147 QGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRI-PVKWM 205 Query: 353 APEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 A E + + YT D W+ G LL+E++ G +P+ Sbjct: 206 AIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPY 239 >4IC8-A nrPDB Length = 442 Score = 71.6 bits (174), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 59/220 (26%), Positives = 103/220 (46%), Gaps = 19/220 (8%) Query: 181 VTKNTFRQYRVL---GKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQI 237 VT + +Y ++ G G +G V + + R TG+ A KK+ L E +I Sbjct: 49 VTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNA-FDVVTNAKRTLRELKI 107 Query: 238 LEKVNSRFVVSL------AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFY 291 L+ ++++ Y ++ +VL LM DL I+ R Y Sbjct: 108 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMES-DLHQIIHSSQPLTLEHVRYFLY 166 Query: 292 AAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA----VHVPEGQTIKGR-V 346 ++ GL+ +H ++++RDLKP N+L++++ ++I D G+A E Q V Sbjct: 167 --QLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYV 224 Query: 347 GTVGYMAPEVVKN-ERYTFSPDWWALGCLLYEMIAGQSPF 385 T Y APE++ + YT + D W++GC+ EM+A + F Sbjct: 225 ATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLF 264 >5LPZ-A nrPDB Length = 332 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 97/209 (46%), Gaps = 12/209 (5%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 N F ++G GGFG+V ++ G A KKL +G+ + E + + K+ Sbjct: 17 NGFHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIHV---SGQGDREFMAEMETIGKIKH 72 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC--GLED 301 R +V L + D LV M G L+ ++ +AG + I GL Sbjct: 73 RNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAF 132 Query: 302 LHRE---RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT---IKGRVGTVGYMAPE 355 LH I++RD+K N+LLD++ R+SD G+A + T + GT GY+ PE Sbjct: 133 LHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPE 192 Query: 356 VVKNERYTFSPDWWALGCLLYEMIAGQSP 384 ++ R + D ++ G +L E++ G+ P Sbjct: 193 YYQSFRCSTKGDVYSYGVVLLELLTGKRP 221 >2RIO-A nrPDB Length = 434 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 88/331 (26%), Positives = 141/331 (42%), Gaps = 52/331 (15%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 KN ++LG G G V Q G+ A K++ +AL E ++L + + Sbjct: 14 KNLVVSEKILGYGSSGTVV-FQGSFQGRPVAVKRMLIDFCD------IALMEIKLLTESD 66 Query: 243 SRFVVSLAYAYETKD---ALCLVLTLMNGGDL--KFHIYHMGQAGFPEARAVFYAAEICC 297 V Y ET D + L L +N DL ++ E + +I Sbjct: 67 DHPNVIRYYCSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIAS 126 Query: 298 GLEDLHRERIVYRDLKPENILLD-------------DHGHIRISDLGLAVHVPEGQT--- 341 G+ LH +I++RDLKP+NIL+ ++ I ISD GL + GQ+ Sbjct: 127 GVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFR 186 Query: 342 --IKGRVGTVGYMAPEVVKNE-------RYTFSPDWWALGCLLYEMIA-GQSPFQQRKKK 391 + GT G+ APE+++ R T S D +++GC+ Y +++ G+ PF K Sbjct: 187 TNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGD--KY 244 Query: 392 IKREEVERLVKEVPEE---YSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 + + R + + E + +A L SQ++ DP +R +A +V HPLF Sbjct: 245 SRESNIIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKR-----PTAMKVLRHPLF 299 Query: 449 ----KKLNFKRLGAGMLEPPFKPDPQAIYCK 475 KKL F + LE + P A+ K Sbjct: 300 WPKSKKLEFLLKVSDRLEIENRDPPSALLMK 330 >2QKW-B nrPDB Length = 321 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 61/212 (28%), Positives = 100/212 (47%), Gaps = 15/212 (7%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 N F ++G G FG+V +R K+ L+++ + +G E + L Sbjct: 39 NNFDHKFLIGHGVFGKVYKGVLRDGAKV----ALKRRTPESSQGIEEFETEIETLSFCRH 94 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVF-YAAEICCG---- 298 +VSL + ++ + L+ M G+LK H+Y + P + EIC G Sbjct: 95 PHLVSLIGFCDERNEMILIYKYMENGNLKRHLY---GSDLPTMSMSWEQRLEICIGAARG 151 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPE-GQTIKGRV--GTVGYMAPE 355 L LH I++RD+K NILLD++ +I+D G++ E QT V GT+GY+ PE Sbjct: 152 LHYLHTRAIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPE 211 Query: 356 VVKNERYTFSPDWWALGCLLYEMIAGQSPFQQ 387 R T D ++ G +L+E++ +S Q Sbjct: 212 YFIKGRLTEKSDVYSFGVVLFEVLCARSAIVQ 243 >4ZSG-A nrPDB Length = 347 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 59/220 (26%), Positives = 103/220 (46%), Gaps = 19/220 (8%) Query: 181 VTKNTFRQYRVL---GKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQI 237 VT + +Y ++ G G +G V + + R TG+ A KK+ L E +I Sbjct: 1 VTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNA-FDVVTNAKRTLRELKI 59 Query: 238 LEKVNSRFVVSL------AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFY 291 L+ ++++ Y ++ +VL LM DL I+ R Y Sbjct: 60 LKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMES-DLHQIIHSSQPLTLEHVRYFLY 118 Query: 292 AAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA----VHVPEGQTIKGR-V 346 ++ GL+ +H ++++RDLKP N+L++++ ++I D G+A E Q V Sbjct: 119 --QLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYV 176 Query: 347 GTVGYMAPEVVKN-ERYTFSPDWWALGCLLYEMIAGQSPF 385 T Y APE++ + YT + D W++GC+ EM+A + F Sbjct: 177 ATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLF 216 >4YFF-A nrPDB Length = 311 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 55/207 (26%), Positives = 94/207 (45%), Gaps = 9/207 (4%) Query: 189 YRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVS 248 + ++G G FG+V + R K+ A K+ + M E IL ++N V+ Sbjct: 47 HEIIGSGSFGKVY--KGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQ 104 Query: 249 LAYA-YETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR--E 305 A +V ++GG L F + H + + A ++ G+E LH + Sbjct: 105 FVGACLNDPSQFAIVTQYISGGSL-FSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQ 163 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLA--VHVPEGQTIKGRVGTVGYMAPEVVKN-ERY 362 I++RDL NILL + GH ++D G + + + + + G + +MAPEV RY Sbjct: 164 PIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRY 223 Query: 363 TFSPDWWALGCLLYEMIAGQSPFQQRK 389 T D ++ L+E++ G+ PF K Sbjct: 224 TIKADVFSYALCLWEILTGEIPFAHLK 250 >5LPV-A nrPDB Length = 296 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 97/209 (46%), Gaps = 12/209 (5%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 N F ++G GGFG+V ++ G A KKL +G+ + E + + K+ Sbjct: 17 NGFHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIHV---SGQGDREFMAEMETIGKIKH 72 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC--GLED 301 R +V L + D LV M G L+ ++ +AG + I GL Sbjct: 73 RNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAF 132 Query: 302 LHRE---RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT---IKGRVGTVGYMAPE 355 LH I++RD+K N+LLD++ R+SD G+A + T + GT GY+ PE Sbjct: 133 LHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPE 192 Query: 356 VVKNERYTFSPDWWALGCLLYEMIAGQSP 384 ++ R + D ++ G +L E++ G+ P Sbjct: 193 YYQSFRCSTKGDVYSYGVVLLELLTGKRP 221 >6CQF-A nrPDB Length = 297 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 56/202 (27%), Positives = 95/202 (47%), Gaps = 17/202 (8%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 LG G +GEV + + +G + A K +K + ++ +K+IL R +AY Sbjct: 24 LGGGTYGEVFKARDKVSGDLVALK-----MVKMEPDDDVSTLQKEILILKTCRHANIVAY 78 Query: 252 --AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 +Y L + + G L+ IY + E + + E+ GL LH ++ ++ Sbjct: 79 HGSYLWLQKLWICMEFCGAGSLQ-DIYQV-TGSLSELQISYVCREVLQGLAYLHSQKKIH 136 Query: 310 RDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVG---YMAPEVVK---NERYT 363 RD+K NIL++D G +R++D G++ + G T+ R+ +G +MAPEV Y Sbjct: 137 RDIKGANILINDAGEVRLADFGISAQI--GATLARRLAFIGTPYWMAPEVAAVALKGGYN 194 Query: 364 FSPDWWALGCLLYEMIAGQSPF 385 D W+LG E+ Q P Sbjct: 195 ELCDIWSLGITAIELAELQPPL 216 >4C59-A nrPDB Length = 340 Score = 70.9 bits (172), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 68/236 (28%), Positives = 106/236 (44%), Gaps = 38/236 (16%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS-- 243 R RVL +GGF V Q +G+ YA K+L +K + + E ++K++ Sbjct: 29 LRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRA---IIQEVCFMKKLSGHP 85 Query: 244 ---RFVVSLAYAYETKD---ALCLVLTLMNGGDLKFHIYHM---GQAGFPEARAVFYAAE 294 +F + + E D A L+LT + G L + M G +FY + Sbjct: 86 NIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFY--Q 143 Query: 295 ICCGLEDLHRER--IVYRDLKPENILLDDHGHIRISDLGLAV---HVPEGQTIKGRVGTV 349 C ++ +HR++ I++RDLK EN+LL + G I++ D G A H P+ R V Sbjct: 144 TCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALV 203 Query: 350 ----------GYMAPEVVKNERYTFSP-----DWWALGCLLYEMIAGQSPFQQRKK 390 Y PE++ + Y+ P D WALGC+LY + Q PF+ K Sbjct: 204 EEEITRNTTPMYRTPEII--DLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAK 257 >4U41-A nrPDB Length = 332 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 52/214 (24%), Positives = 98/214 (45%), Gaps = 19/214 (8%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 F V+G G +G+V + TG++ A K ++ + + + E + L + + + R Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMD---VTEDEEEEIKLEINMLKKYSHHRN 82 Query: 246 VVSLAYAYETK------DALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 + + A+ K D L LV+ G + + + E + + EI GL Sbjct: 83 IATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGL 142 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR---VGTVGYMAPEV 356 LH +++RD+K +N+LL ++ +++ D G++ + +T+ R +GT +MAPEV Sbjct: 143 AHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQL--DRTVGRRNTFIGTPYWMAPEV 200 Query: 357 VK-----NERYTFSPDWWALGCLLYEMIAGQSPF 385 + + Y + D W+ G EM G P Sbjct: 201 IACDENPDATYDYRSDLWSCGITAIEMAEGAPPL 234 >2ZMD-A nrPDB Length = 390 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 60/230 (26%), Positives = 105/230 (45%), Gaps = 31/230 (13%) Query: 187 RQYRVL---GKGGFGEVCACQVRATGKMYACKKL-----EKKRIKKRKGEAMALNEKQIL 238 R Y +L G GG +V + ++YA K + + + + + E LN+ Q Sbjct: 56 RIYSILKQIGSGGSSKVFQV-LNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQ-- 112 Query: 239 EKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 +S ++ L Y YE D + +M G++ + + + Y + Sbjct: 113 --QHSDKIIRL-YDYEITDQY--IYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEA 167 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV-PEGQTI--KGRVGTVGYMAPE 355 + +H+ IV+ DLKP N L+ D G +++ D G+A + P+ ++ +VG V YM PE Sbjct: 168 VHTIHQHGIVHSDLKPANFLIVD-GMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPE 226 Query: 356 VVKNERYT-----------FSPDWWALGCLLYEMIAGQSPFQQRKKKIKR 394 +K+ + D W+LGC+LY M G++PFQQ +I + Sbjct: 227 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISK 276 >5X8I-B nrPDB Length = 346 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 67/246 (27%), Positives = 103/246 (41%), Gaps = 31/246 (12%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN-----SRF 245 LG+G FG+V C G + K+ K R EA A +E Q+LE +N S F Sbjct: 20 TLGEGAFGKVVECIDHKAGGRHVAVKIVKN--VDRYCEA-ARSEIQVLEHLNTTDPNSTF 76 Query: 246 -VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 V + +E +C+V L+ F I G F A +IC + LH Sbjct: 77 RCVQMLEWFEHHGHICIVFELLGLSTYDF-IKENGFLPFRLDHIRKMAYQICKSVNFLHS 135 Query: 305 ERIVYRDLKPENILLDDHGH-------------------IRISDLGLAVHVPEGQTIKGR 345 ++ + DLKPENIL + I++ D G A + E + Sbjct: 136 NKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHS--TL 193 Query: 346 VGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVP 405 V T Y APEV+ ++ D W++GC+L E G + F K +ER++ +P Sbjct: 194 VSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLP 253 Query: 406 EEYSER 411 + ++ Sbjct: 254 KHMIQK 259 >4QTB-A nrPDB Length = 380 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 56/210 (26%), Positives = 95/210 (45%), Gaps = 16/210 (7%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 + Q + +G+G +G V + A KK+ + + L E QIL + Sbjct: 43 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISP--FEHQTYCQRTLREIQILLRFRHEN 100 Query: 246 VVSL-----AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 V+ + A E + +V LM K + ++ +I GL+ Sbjct: 101 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKL----LKSQQLSNDHICYFLYQILRGLK 156 Query: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLA-VHVPEGQT---IKGRVGTVGYMAPEV 356 +H +++RDLKP N+L++ ++I D GLA + PE + V T Y APE+ Sbjct: 157 YIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 216 Query: 357 VKNER-YTFSPDWWALGCLLYEMIAGQSPF 385 + N + YT S D W++GC+L EM++ + F Sbjct: 217 MLNSKGYTKSIDIWSVGCILAEMLSNRPIF 246 >4E20-A nrPDB Length = 290 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 72/256 (28%), Positives = 117/256 (45%), Gaps = 25/256 (9%) Query: 183 KNTFRQYRVLGKGGFGEVCAC----QVRATGKMYACKKL-EKKRIKKRKGEAMALNEKQI 237 K ++ R LG+G FG+V TG+M A K L E + R G E +I Sbjct: 7 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQ---REIEI 63 Query: 238 LEKVNSRFVVSLAYAYETK--DALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEI 295 L + +V E + ++ LV+ + G L+ + + + A+ + +A +I Sbjct: 64 LRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDY---LPRHCVGLAQLLLFAQQI 120 Query: 296 CCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRV-----GTVG 350 C G+ LH + ++R L N+LLD+ ++I D GLA VPEG RV V Sbjct: 121 CEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYY-RVREDGDSPVF 179 Query: 351 YMAPEVVKNERYTFSPDWWALGCLLYEMI----AGQSPFQQRKKKIKREEVERLVKEVPE 406 + APE +K ++ ++ D W+ G LYE++ + QSP + + I + + V + E Sbjct: 180 WYAPECLKECKFYYASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVLRLTE 239 Query: 407 --EYSERFSPQARSLC 420 E ER R C Sbjct: 240 LLERGERLPRPDRCPC 255 >3DKO-A nrPDB Length = 318 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 60/206 (29%), Positives = 103/206 (50%), Gaps = 15/206 (7%) Query: 190 RVLGKGGFGEVCACQVRATGK---MYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFV 246 RV+G G FGEVC+ +++ GK A K L+ +K++ + L E I+ + + V Sbjct: 49 RVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRD--FLCEASIMGQFDHPNV 106 Query: 247 VSLAYAYETKDALCLVLTLMNGGDL-KFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 V L + +V+ M G L F H GQ F + V I G+ L Sbjct: 107 VHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQ--FTVIQLVGMLRGIAAGMRYLADM 164 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHV---PEG--QTIKGRVGTVGYMAPEVVKNE 360 V+RDL NIL++ + ++SD GL+ + PE T G++ V + APE ++ Sbjct: 165 GYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKI-PVRWTAPEAIQYR 223 Query: 361 RYTFSPDWWALGCLLYEMIA-GQSPF 385 ++T + D W+ G +++E+++ G+ P+ Sbjct: 224 KFTSASDVWSYGIVMWEVMSYGERPY 249 >2VWV-A nrPDB Length = 302 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 50/205 (24%), Positives = 96/205 (46%), Gaps = 13/205 (6%) Query: 191 VLGKGGFGEVCACQVRATGKMYAC---KKLEKKRIKKRKGEAMALNEKQILEKVNSRFVV 247 V+G G FGEVC +++A GK +C K L+ ++++ E L+E I+ + ++ Sbjct: 23 VIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRRE--FLSEASIMGQFEHPNII 80 Query: 248 SLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERI 307 L + ++ M G L + F + V I G+ L Sbjct: 81 RLEGVVTNSMPVMILTEFMENGALD-SFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSY 139 Query: 308 VYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVG------YMAPEVVKNER 361 V+RDL NIL++ + ++SD GL+ + E + ++G + APE + + Sbjct: 140 VHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTAPEAIAFRK 199 Query: 362 YTFSPDWWALGCLLYEMIA-GQSPF 385 +T + D W+ G +++E+++ G+ P+ Sbjct: 200 FTSASDAWSYGIVMWEVMSFGERPY 224 >6F3F-A nrPDB Length = 455 Score = 70.1 bits (170), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 59/211 (27%), Positives = 102/211 (48%), Gaps = 9/211 (4%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 LG+G FGEV T ++ A K L+ + EA L E Q+++K+ +V L Y Sbjct: 195 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSP---EAF-LQEAQVMKKLRHEKLVQL-Y 248 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 A +++ + +V MN G L + + V +A+I G+ + R V+RD Sbjct: 249 AVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRD 308 Query: 312 LKPENILLDDHGHIRISDLGLAVHVPEGQTI--KGRVGTVGYMAPEVVKNERYTFSPDWW 369 L+ NIL+ ++ +++D GLA + + + +G + + APE R+T D W Sbjct: 309 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 368 Query: 370 ALGCLLYEMIA-GQSPFQQRKKKIKREEVER 399 + G LL E+ G+ P+ + ++VER Sbjct: 369 SFGILLTELTTKGRVPYPGMVNREVLDQVER 399 >6HMD-A nrPDB Length = 365 Score = 70.1 bits (170), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 62/225 (27%), Positives = 96/225 (42%), Gaps = 46/225 (20%) Query: 260 CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILL 319 LV +N D K +Y + + FY E+ L+ H + I++RD+KP N+++ Sbjct: 126 ALVFEYINNTDFK-QLYQI----LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMI 180 Query: 320 DDH-GHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV-VKNERYTFSPDWWALGCLLYE 377 D +R+ D GLA Q RV + + PE+ V + Y +S D W+LGC+L Sbjct: 181 DHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLAS 240 Query: 378 MIAGQSPF---QQRKKKIKR-------EEVERLVKE------------------------ 403 MI + PF Q ++ R EE+ +K+ Sbjct: 241 MIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENF 300 Query: 404 VPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 + E SP+A L +LL D +RL +A+E EHP F Sbjct: 301 IHSENRHLVSPEALDLLDKLLRYDHQQRL-----TAKEAMEHPYF 340 >2W96-B nrPDB Length = 306 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 52/193 (26%), Positives = 82/193 (42%), Gaps = 6/193 (3%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKL-----EKKRIKKRKGEAMALNEKQILEKVNSRFV 246 +G G +G V + +G A K + E+ E L + E N + Sbjct: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFEHPNVVRL 71 Query: 247 VSLAYAYETKDALCLVLTLMN-GGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 + + T + + L + DL+ ++ G P + GL+ LH Sbjct: 72 MDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHAN 131 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFS 365 IV+RDLKPENIL+ G ++++D GLA + V T+ Y APEV+ Y Sbjct: 132 CIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEVLLQSTYATP 191 Query: 366 PDWWALGCLLYEM 378 D W++GC+ EM Sbjct: 192 VDMWSVGCIFAEM 204 >3HKO-A nrPDB Length = 345 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 76/314 (24%), Positives = 129/314 (41%), Gaps = 58/314 (18%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKR--KGEAMALNEKQILEKVNSRFVVSL 249 +G+G +G V T + A K + K +I++ K E ++++K++ + L Sbjct: 34 IGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKLHHPNIARL 93 Query: 250 AYAYETKDALCLVLTLMNGGDL--KFHIY----------------------------HMG 279 YE + +CLV+ L +GG L K +++ + Sbjct: 94 YEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECNEEAINGS 153 Query: 280 QAGFPEARAVF--------YAAEICCGLEDLHRERIVYRDLKPENILLDDHG--HIRISD 329 GF E+ +I L LH + I +RD+KPEN L + I++ D Sbjct: 154 IHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKSFEIKLVD 213 Query: 330 LGLA-----VHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSP--DWWALGCLLYEMIAGQ 382 GL+ ++ E + + GT ++APEV+ ++ P D W+ G LL+ ++ G Sbjct: 214 FGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVLLHLLLMGA 273 Query: 383 SPF--QQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAR 440 PF I + ++L E P SP AR L S LL ++ ER A Sbjct: 274 VPFPGVNDADTISQVLNKKLCFENPN--YNVLSPLARDLLSNLLNRNVDERF-----DAM 326 Query: 441 EVKEHPLFKKLNFK 454 +HP + + K Sbjct: 327 RALQHPWISQFSDK 340 >5SYS-A nrPDB Length = 286 Score = 69.7 bits (169), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 71/259 (27%), Positives = 119/259 (45%), Gaps = 22/259 (8%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 + + + R LG+G FGE T ++ A K L+ + EA L E Q+++K Sbjct: 15 IPRESLRLEVKLGQGCFGECWMGTWNGTTRV-AIKTLKPGTMSP---EAF-LQEAQVMKK 69 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDL-KFHIYHMGQAGFPEARAVFYAAEICCGL 299 + +V L YA +++ + +V M+ G L F MG+ + V AA+I G+ Sbjct: 70 LRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKY-LRLPQLVDMAAQIASGM 127 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI--KGRVGTVGYMAPEVV 357 + R V+RDL+ NIL+ ++ +++D GLA + + + +G + + APE Sbjct: 128 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 187 Query: 358 KNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQA 416 R+T D W+ G LL E+ G+ P+ + ++VER Y P+ Sbjct: 188 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER-------GYRMPCPPEC 240 Query: 417 RSLCSQLLC----KDPAER 431 L+C KDP ER Sbjct: 241 PESLHDLMCQCWRKDPEER 259 >5UIU-A nrPDB Length = 323 Score = 69.3 bits (168), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 67/227 (29%), Positives = 101/227 (44%), Gaps = 21/227 (9%) Query: 169 RFLQWKWLERQPVTKNTFRQYRV------LGKGGFGEVCACQVR----ATGKMYACKKLE 218 RF + + E + VT N F + + +G+GGFG V V A K+ A + Sbjct: 27 RFHSFSFYELKNVTNN-FDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDIT 85 Query: 219 KKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHM 278 + +K++ + E +++ K +V L D LCLV M G L + + Sbjct: 86 TEELKQQFDQ-----EIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCL 140 Query: 279 -GQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVP 337 G A G+ LH ++RD+K NILLD+ +ISD GLA Sbjct: 141 DGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASE 200 Query: 338 E-GQTIKGR--VGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAG 381 + QT+ VGT YMAPE ++ E T D ++ G +L E+I G Sbjct: 201 KFAQTVMTSRIVGTTAYMAPEALRGE-ITPKSDIYSFGVVLLEIITG 246 >2H8H-A nrPDB Length = 535 Score = 69.3 bits (168), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 60/222 (27%), Positives = 106/222 (47%), Gaps = 9/222 (4%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 + + + R LG+G FGEV T ++ A K L+ + EA L E Q+++K Sbjct: 264 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSP---EAF-LQEAQVMKK 318 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 + +V L YA +++ + +V M+ G L + + V AA+I G+ Sbjct: 319 LRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 377 Query: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI--KGRVGTVGYMAPEVVK 358 + R V+RDL+ NIL+ ++ +++D GLA + + + +G + + APE Sbjct: 378 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 437 Query: 359 NERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVER 399 R+T D W+ G LL E+ G+ P+ + ++VER Sbjct: 438 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 479 >6FEX-A nrPDB Length = 321 Score = 69.3 bits (168), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 78/295 (26%), Positives = 122/295 (41%), Gaps = 48/295 (16%) Query: 192 LGKGGFGEVCACQV----------------RATGKMYACKKLEKKRIKKRKGEAMALNEK 235 LG+G FGEV C+V + + A K L K + + L E Sbjct: 24 LGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDF--LKEV 81 Query: 236 QILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDL-KFHIYHM----GQAGFPEARAVF 290 +I+ ++ ++ L D LC++ M GDL +F H G P + Sbjct: 82 KIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDPTIS 141 Query: 291 Y------AAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT--I 342 Y AA+I G+ L V+RDL N L+ ++ I+I+D G++ ++ G + Sbjct: 142 YPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRV 201 Query: 343 KGR-VGTVGYMAPEVVKNERYTFSPDWWALGCLLYE--MIAGQSPFQQRKKKIKREEVER 399 +GR V + +MA E + ++T + D WA G L+E M+ PF Q Sbjct: 202 QGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTD--------- 252 Query: 400 LVKEVPEEYSERFSPQARS--LCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 ++V E E F Q R L C L R S RE ++ P F +L+ Sbjct: 253 --EQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWS-RESEQRPPFSQLH 304 >2W1I-A nrPDB Length = 326 Score = 69.3 bits (168), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 54/229 (23%), Positives = 109/229 (47%), Gaps = 14/229 (6%) Query: 163 DSIYFNRFLQWKWLERQPVT--KNTFRQYRVLGKGGFGEVCACQVR----ATGKMYACKK 216 +++YF + + +R P + + + LGKG FG V C+ TG++ A KK Sbjct: 18 ENLYFQGAMGSAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKK 77 Query: 217 LEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIY 276 L+ + + + + L+ N + Y+ ++ L L++ + G L+ ++ Sbjct: 78 LQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRN-LKLIMEYLPYGSLRDYL- 135 Query: 277 HMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV 336 + + + Y ++IC G+E L +R ++RDL NIL+++ ++I D GL + Sbjct: 136 QKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVL 195 Query: 337 PEGQTIKGRVGTVG-----YMAPEVVKNERYTFSPDWWALGCLLYEMIA 380 P+ + +V G + APE + +++ + D W+ G +LYE+ Sbjct: 196 PQDKEYY-KVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFT 243 >5TE0-A nrPDB Length = 347 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 57/187 (30%), Positives = 84/187 (44%), Gaps = 24/187 (12%) Query: 262 VLTLMN---GGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH--RERIVYRDLKPEN 316 VL LM+ GG + + Q GF E + + C + LH + I++RDLK EN Sbjct: 97 VLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVEN 156 Query: 317 ILLDDHGHIRISDLGLAVHVPEGQTIKG---------RVGTVGYMAPEVVK---NERYTF 364 ILL D GH + D G A + + +G + T+ Y APE+V + T Sbjct: 157 ILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITT 216 Query: 365 SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLL 424 D WALGCLLY++ PF + + I +P+ + R+S L +L Sbjct: 217 KADIWALGCLLYKLCYFTLPFGESQVAICDGNF-----TIPD--NSRYSQDMHCLIRYML 269 Query: 425 CKDPAER 431 DP +R Sbjct: 270 EPDPDKR 276 >1JPA-A nrPDB Length = 312 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 52/207 (25%), Positives = 100/207 (48%), Gaps = 15/207 (7%) Query: 190 RVLGKGGFGEVCACQVRATGK---MYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFV 246 +V+G G FGEVC+ ++ GK A K L+ +K++ + L+E I+ + + V Sbjct: 39 QVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDF--LSEASIMGQFDHPNV 96 Query: 247 VSLAYAYETKDALCLVLTLMNGGDL-KFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 + L + ++ M G L F + GQ F + V I G++ L Sbjct: 97 IHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQ--FTVIQLVGMLRGIAAGMKYLADM 154 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVG------YMAPEVVKN 359 V+RDL NIL++ + ++SD GL+ + + + +G + APE ++ Sbjct: 155 NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQY 214 Query: 360 ERYTFSPDWWALGCLLYEMIA-GQSPF 385 ++T + D W+ G +++E+++ G+ P+ Sbjct: 215 RKFTSASDVWSYGIVMWEVMSYGERPY 241 >2PL0-A nrPDB Length = 289 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 53/214 (24%), Positives = 97/214 (45%), Gaps = 9/214 (4%) Query: 175 WLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNE 234 W + V + T + LG G FGEV K+ A K L++ + L E Sbjct: 14 WEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKV-AVKSLKQGSMSPDA----FLAE 68 Query: 235 KQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAE 294 +++++ + +V L YA T++ + ++ M G L + + + AA+ Sbjct: 69 ANLMKQLQHQRLVRL-YAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQ 127 Query: 295 ICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI--KGRVGTVGYM 352 I G+ + ++RDL+ NIL+ D +I+D GLA + + + +G + + Sbjct: 128 IAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWT 187 Query: 353 APEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 APE + +T D W+ G LL E++ G+ P+ Sbjct: 188 APEAINYGTFTIKSDVWSFGILLTEIVTHGRIPY 221 >6O6Q-A nrPDB Length = 335 Score = 68.9 bits (167), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 67/250 (26%), Positives = 117/250 (46%), Gaps = 30/250 (12%) Query: 143 QELTRLTHEYLSVAP--FADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEV 200 Q ++R+ + LS P + DY D L KW P + + R LG+G + EV Sbjct: 10 QSVSRVYADVLSTKPQSYWDYDD-------LNIKW---NP--QENYEILRKLGRGKYSEV 57 Query: 201 ---CACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKD 257 + R + K +++K+IK+ E L K +++ N ++ + ++K Sbjct: 58 FLGIDLEKREKVVIKVLKPVKRKKIKR---EISIL--KNLVDGPNIIAMLDVVREPQSKT 112 Query: 258 ALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENI 317 L+ +N D + +Y F + FY E+ L+ H I++RD+KP N+ Sbjct: 113 P-GLIFEHINNIDFR-SLY----PTFTDYDIRFYMYELLKALDYSHSMGIMHRDVKPHNV 166 Query: 318 LLD-DHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER-YTFSPDWWALGCLL 375 ++D D +R+ D GLA + G RV + + PE++ + R Y +S D W+ GC+L Sbjct: 167 MIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYFKGPELLVDYRLYDYSLDMWSFGCML 226 Query: 376 YEMIAGQSPF 385 M+ + PF Sbjct: 227 ASMVFMKEPF 236 >5NGU-A nrPDB Length = 381 Score = 68.6 bits (166), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 55/204 (26%), Positives = 93/204 (45%), Gaps = 16/204 (7%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL-- 249 +G+G +G VC+ A KK+ + + L E +IL + ++ + Sbjct: 50 IGEGAYGMVCSAYDNLNKVRVAIKKISP--FEHQTYCQRTLREIKILLRFRHENIIGIND 107 Query: 250 ---AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRER 306 A E + +V LM K + ++ +I GL+ +H Sbjct: 108 IIRAPTIEQMKDVYIVQDLMETDLYKL----LKTQHLSNDHICYFLYQILRGLKYIHSAN 163 Query: 307 IVYRDLKPENILLDDHGHIRISDLGLA-VHVPEGQT---IKGRVGTVGYMAPEVVKNER- 361 +++RDLKP N+LL+ ++I D GLA V P+ + V T Y APE++ N + Sbjct: 164 VLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKG 223 Query: 362 YTFSPDWWALGCLLYEMIAGQSPF 385 YT S D W++GC+L EM++ + F Sbjct: 224 YTKSIDIWSVGCILAEMLSNRPIF 247 >4UY9-A nrPDB Length = 323 Score = 68.6 bits (166), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 58/208 (27%), Positives = 96/208 (46%), Gaps = 18/208 (8%) Query: 191 VLGKGGFGEVC-ACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 ++G GGFG+V A + + A + + I + E ++ + +++L Sbjct: 16 IIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVR--QEAKLFAMLKHPNIIAL 73 Query: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIV- 308 + LCLV+ GG L + P V +A +I G+ LH E IV Sbjct: 74 RGVCLKEPNLCLVMEFARGGPLN---RVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVP 130 Query: 309 --YRDLKPENILL---DDHGHI-----RISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVK 358 +RDLK NIL+ ++G + +I+D GLA T GT +MAPEV++ Sbjct: 131 IIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREW-HRTTKMSAAGTYAWMAPEVIR 189 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPFQ 386 ++ D W+ G LL+E++ G+ PF+ Sbjct: 190 ASMFSKGSDVWSYGVLLWELLTGEVPFR 217 >4PWN-A nrPDB Length = 274 Score = 68.6 bits (166), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 75/269 (27%), Positives = 119/269 (44%), Gaps = 23/269 (8%) Query: 192 LGKGGFGEVC-ACQVRATGKMYAC----KKLEKKRIKKRKGEAMALNEKQILEKVNSRFV 246 +G+G F V T ++ C +KL K ++ K EA L Q V RF Sbjct: 18 IGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIV--RFY 75 Query: 247 VSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRER 306 S + K + LV LM G LK ++ R+ + +I GL+ LH Sbjct: 76 DSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRS--WCRQILKGLQFLHTRT 133 Query: 307 --IVYRDLKPENILLDD-HGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYT 363 I++RDLK +NI + G ++I DLGLA K +GT +MAPE+ + E+Y Sbjct: 134 PPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEMYE-EKYD 192 Query: 364 FSPDWWALGCLLYEMIAGQSPFQ--QRKKKIKREEVERLVKEVPEEYSERFSPQARSLCS 421 S D +A G + EM + P+ Q +I R V VK P + + P+ + + Sbjct: 193 ESVDVYAFGMCMLEMATSEYPYSECQNAAQIYR-RVTSGVK--PASFDKVAIPEVKEIIE 249 Query: 422 QLLCKDPAERLGCRGGSAREVKEHPLFKK 450 + ++ ER S +++ H F++ Sbjct: 250 GCIRQNKDERY-----SIKDLLNHAFFQE 273 >4IAN-A nrPDB Length = 358 Score = 68.2 bits (165), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 67/220 (30%), Positives = 103/220 (46%), Gaps = 36/220 (16%) Query: 187 RQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAM---ALNEKQILEKVNS 243 ++Y V G G G V + VRA A +++ K I R E M L E + L+K+N Sbjct: 30 KRYNVYGYTGQG-VFSNVVRARDNARANQEVAVKII--RNNELMQKTGLKELEFLKKLND 86 Query: 244 -----RF-VVSLAYAYETKDALCLVL--TLMN--------GGDLKFHIYHMGQAGFPEAR 287 +F + L + K LCLV MN G D+ HI + Sbjct: 87 ADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHI-----------K 135 Query: 288 AV-FYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHI-RISDLGLAVHVPEGQTIKGR 345 AV Y+ ++ L+ L R I++ D+KP+NIL+++ I ++ D G A HV + Sbjct: 136 AVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYL 195 Query: 346 VGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPF 385 V Y APE++ + Y + D W++GC LYE+ G+ F Sbjct: 196 VSRF-YRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILF 234 >2R2P-A nrPDB Length = 295 Score = 68.2 bits (165), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 60/228 (26%), Positives = 109/228 (47%), Gaps = 20/228 (8%) Query: 190 RVLGKGGFGEVCACQVRATGKM---YACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFV 246 RV+G G FGEVC+ +++ GK A K L+ +K++ + L E I+ + + + Sbjct: 28 RVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDF--LGEASIMGQFDHPNI 85 Query: 247 VSLAYAYETKDALCLVLTLMNGGDL-KFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 + L + +V M G L F + GQ F + V I G++ L Sbjct: 86 IHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQ--FTVIQLVGMLRGISAGMKYLSDM 143 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHV---PEGQ-TIKGRVGTVGYMAPEVVKNER 361 V+RDL NIL++ + ++SD GL+ + PE T +G + + APE + + Sbjct: 144 GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRK 203 Query: 362 YTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEY 408 +T + D W+ G +++E+++ G+ P+ + + ++K V E Y Sbjct: 204 FTSASDVWSYGIVMWEVVSYGERPYWEMTN-------QDVIKAVEEGY 244 >1K9A-A nrPDB Length = 450 Score = 68.2 bits (165), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 51/198 (25%), Positives = 92/198 (46%), Gaps = 11/198 (5%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV-NSRFVVS 248 + +GKG FG+V R K+ K IK L E ++ ++ +S V Sbjct: 199 QTIGKGEFGDVMLGDYRGN-------KVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQL 251 Query: 249 LAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIV 308 L E K L +V M G L ++ G++ + ++ ++C +E L V Sbjct: 252 LGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFV 311 Query: 309 YRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDW 368 +RDL N+L+ + ++SD GL Q G++ V + APE ++ ++++ D Sbjct: 312 HRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDT-GKL-PVKWTAPEALREKKFSTKSDV 369 Query: 369 WALGCLLYEMIA-GQSPF 385 W+ G LL+E+ + G+ P+ Sbjct: 370 WSFGILLWEIYSFGRVPY 387 >5HLW-A nrPDB Length = 299 Score = 68.2 bits (165), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 53/202 (26%), Positives = 98/202 (48%), Gaps = 10/202 (4%) Query: 191 VLGKGGFGEVC-ACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 V+G+G FG V + GK C RI + L E I++ + V+SL Sbjct: 27 VIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL 86 Query: 250 -AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVF-YAAEICCGLEDLHRERI 307 ++ + +VL M GDL+ I + P + + + ++ G++ L ++ Sbjct: 87 LGICLRSEGSPLVVLPYMKHGDLRNFI--RNETHNPTVKDLIGFGLQVAKGMKYLASKKF 144 Query: 308 VYRDLKPENILLDDHGHIRISDLGLA--VHVPEGQTIKGRVGT---VGYMAPEVVKNERY 362 V+RDL N +LD+ ++++D GLA +H E ++ + G V +MA E ++ +++ Sbjct: 145 VHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQTQKF 204 Query: 363 TFSPDWWALGCLLYEMIAGQSP 384 T D W+ G LL+E++ +P Sbjct: 205 TTKSDVWSFGVLLWELMTRGAP 226 >3IO7-A nrPDB Length = 313 Score = 68.2 bits (165), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 50/198 (25%), Positives = 96/198 (48%), Gaps = 12/198 (6%) Query: 192 LGKGGFGEVCACQVR----ATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVV 247 LGKG FG V C+ TG++ A KKL+ + + + + L+ N Sbjct: 36 LGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYK 95 Query: 248 SLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERI 307 + Y+ ++ L L++ + G L+ ++ + + + Y ++IC G+E L +R Sbjct: 96 GVCYSAGRRN-LKLIMEYLPYGSLRDYL-QKHKERIDHIKLLQYTSQICKGMEYLGTKRY 153 Query: 308 VYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVG-----YMAPEVVKNERY 362 ++RDL NIL+++ ++I D GL +P+ + +V G + APE + ++ Sbjct: 154 IHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYY-KVKEPGESPIFWYAPESLTESKF 212 Query: 363 TFSPDWWALGCLLYEMIA 380 + + D W+ G +LYE+ Sbjct: 213 SVASDVWSFGVVLYELFT 230 >4AU8-A nrPDB Length = 296 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 70/286 (24%), Positives = 123/286 (43%), Gaps = 38/286 (13%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 +G+G +G V + R T ++ A K++ + AL E +L+++ + +V L Sbjct: 14 IGEGTYGTVFKAKNRETHEIVALKRVRLDD-DDEGVPSSALREICLLKELKHKNIVRLHD 72 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 + L LV + DLK + PE F ++ GL H +++RD Sbjct: 73 VLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPEIVKSFLF-QLLKGLGFCHSRNVLHRD 130 Query: 312 LKPENILLDDHGHIRISDLGL--AVHVPEGQTIKGRVGTVGYMAPEVVKNER-YTFSPDW 368 LKP+N+L++ +G ++++D GL A +P + V T+ Y P+V+ + Y+ S D Sbjct: 131 LKPQNLLINRNGELKLADFGLARAFGIPV-RCYSAEVVTLWYRPPDVLFGAKLYSTSIDM 189 Query: 369 WALGCLLYEMI-AGQSPFQQRKKKIKREEVERLVKEVPEE-------------------- 407 W+ GC+ E+ AG+ F + + + RL+ EE Sbjct: 190 WSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT 249 Query: 408 -----YSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 + + R L LL +P +R+ SA E +HP F Sbjct: 250 TSLVNVVPKLNATGRDLLQNLLKCNPVQRI-----SAEEALQHPYF 290 >6HV0-A nrPDB Length = 416 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 59/174 (33%), Positives = 87/174 (50%), Gaps = 25/174 (14%) Query: 294 EICCGLEDLHRERIVYRDLKPENILL---DDHGHIR--ISDLGLAVHVPEGQTI----KG 344 + GL LH IV+RDLKP NIL+ + HG I+ ISD GL + G+ G Sbjct: 110 QTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSG 169 Query: 345 RVGTVGYMAPEVVK---NERYTFSPDWWALGCLLYEMIA-GQSPFQ---QRKKKIKREEV 397 GT G++APE++ E T++ D ++ GC+ Y +I+ G PF QR+ I Sbjct: 170 VPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGAC 229 Query: 398 ERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 L PE++ + AR L +++ DP +R SA+ V +HP F L Sbjct: 230 S-LDCLHPEKHEDVI---ARELIEKMIAMDPQKR-----PSAKHVLKHPFFWSL 274 >1BYG-A nrPDB Length = 278 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 51/198 (25%), Positives = 92/198 (46%), Gaps = 11/198 (5%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV-NSRFVVS 248 + +GKG FG+V R K+ K IK L E ++ ++ +S V Sbjct: 27 QTIGKGEFGDVMLGDYRGN-------KVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQL 79 Query: 249 LAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIV 308 L E K L +V M G L ++ G++ + ++ ++C +E L V Sbjct: 80 LGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFV 139 Query: 309 YRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDW 368 +RDL N+L+ + ++SD GL Q G++ V + APE ++ ++++ D Sbjct: 140 HRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDT-GKL-PVKWTAPEALREKKFSTKSDV 197 Query: 369 WALGCLLYEMIA-GQSPF 385 W+ G LL+E+ + G+ P+ Sbjct: 198 WSFGILLWEIYSFGRVPY 215 >3I81-A nrPDB Length = 315 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 62/244 (25%), Positives = 106/244 (43%), Gaps = 31/244 (12%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGK-----MYACKKLEKKRIKKRKGEAMALNEK 235 V + R LG+G FG V + K A K + + + + E LNE Sbjct: 15 VAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEF--LNEA 72 Query: 236 QILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPE---------- 285 ++++ N VV L +++ LM GDLK ++ + PE Sbjct: 73 SVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLR----PEMENNPVLAPP 128 Query: 286 --ARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI- 342 ++ + A EI G+ L+ + V+RDL N ++ + ++I D G+ + E Sbjct: 129 SLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYR 188 Query: 343 KGRVGT--VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVER 399 KG G V +M+PE +K+ +T D W+ G +L+E+ + P+Q + E+V R Sbjct: 189 KGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQ----GLSNEQVLR 244 Query: 400 LVKE 403 V E Sbjct: 245 FVME 248 >3QUP-A nrPDB Length = 323 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 63/243 (25%), Positives = 108/243 (44%), Gaps = 23/243 (9%) Query: 162 LDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQ--------VRATGKMYA 213 LDS+ + L+ K LE + + F R+LGKG FG V Q V+ KM Sbjct: 2 LDSLGISDELKEK-LEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLK 60 Query: 214 CKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDAL---CLVLTLMNGGD 270 + I++ EA + E + + +V ++ K L ++L M GD Sbjct: 61 ADIIASSDIEEFLREAACMKE---FDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGD 117 Query: 271 LKFHIY--HMGQAGF--PEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIR 326 L + +G+ F P V + +I CG+E L ++RDL N +L + + Sbjct: 118 LHAFLLASRIGENPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVC 177 Query: 327 ISDLGLAVHVPEGQTIKGRVGT---VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQ 382 ++D GL+ + G + + V ++A E + + YT D WA G ++E++ GQ Sbjct: 178 VADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQ 237 Query: 383 SPF 385 +P+ Sbjct: 238 TPY 240 >5HVK-A nrPDB Length = 315 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 57/206 (27%), Positives = 97/206 (47%), Gaps = 21/206 (10%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLA 250 VLGKG FG+ R TG++ K+L + + ++ + + LE N + + Sbjct: 21 VLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVL 80 Query: 251 YAYETKDA-LCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 Y KD L + + GG L+ I M + +P ++ V +A +I G+ LH I++ Sbjct: 81 Y----KDKRLNFITEYIKGGTLRGIIKSM-DSQYPWSQRVSFAKDIASGMAYLHSMNIIH 135 Query: 310 RDLKPENILLDDHGHIRISDLGLAVHV------PEGQTI------KGRVGTVG---YMAP 354 R+L N L+ ++ ++ ++D GLA + PEG K R VG +MAP Sbjct: 136 RNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAP 195 Query: 355 EVVKNERYTFSPDWWALGCLLYEMIA 380 E++ Y D ++ G +L E+I Sbjct: 196 EMINGRSYDEKVDVFSFGIVLCEIIG 221 >4M7I-A nrPDB Length = 299 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 71/297 (23%), Positives = 131/297 (44%), Gaps = 44/297 (14%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRK-GEAMALNEKQILEKVNSR 244 F + LG+GGFG V + + YA K++ R+ R+ + E + L K+ Sbjct: 7 FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRI---RLPNRELAREKVMREVKALAKLEHP 63 Query: 245 FVVSLAYAYETKDA------------LCLVLTLMNGGDLKFHIYHMGQAGFPE---ARAV 289 +V A+ K+ L + + L +LK + G+ E + + Sbjct: 64 GIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLK--DWMNGRCTIEERERSVCL 121 Query: 290 FYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVP---EGQTI---- 342 +I +E LH + +++RDLKP NI +++ D GL + E QT+ Sbjct: 122 HIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPM 181 Query: 343 ------KGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREE 396 G+VGT YM+PE + Y+ D ++LG +L+E++ PF + ++++ Sbjct: 182 PAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLY---PFSTQMERVRTLT 238 Query: 397 VERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNF 453 R +K P +++++ P + +L P ER A + E+ +F+ L+F Sbjct: 239 DVRNLK-FPPLFTQKY-PCEYVMVQDMLSPSPMER-----PEAINIIENAVFEDLDF 288 >4K33-A nrPDB Length = 325 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 62/238 (26%), Positives = 112/238 (47%), Gaps = 32/238 (13%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAM------ALNEKQILEKVNS-R 244 LG+G FG+V + K A K + +K K +A ++E ++++ + + Sbjct: 44 LGEGAFGQVVMAEAIGIDKDRAAKPVTVA-VKMLKDDATDKDLSDLVSEMEMMKMIGKHK 102 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHI---------YHMGQAGFPEARAVFY---- 291 +++L A L +++ G+L+ + Y + PE + F Sbjct: 103 NIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEEQLTFKDLVS 162 Query: 292 -AAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPE----GQTIKGRV 346 A ++ G+E L ++ ++RDL N+L+ + ++I+D GLA V +T GR+ Sbjct: 163 CAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKETTNGRL 222 Query: 347 GTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKE 403 V +MAPE + + YT D W+ G LL+E+ G SP+ I EE+ +L+KE Sbjct: 223 -PVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPY----PGIPVEELFKLLKE 275 >3QD2-B nrPDB Length = 332 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 46/171 (26%), Positives = 82/171 (47%), Gaps = 23/171 (13%) Query: 294 EICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV-------------PEGQ 340 +I +E LH + +++RDLKP NI +++ D GL + P Sbjct: 172 QIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYA 231 Query: 341 TIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERL 400 T G+VGT YM+PE + Y+ D ++LG +L+E++ S +R + I +V L Sbjct: 232 THTGQVGTKLYMSPEQIHGNNYSHKVDIFSLGLILFELLYSFSTQMERVRIIT--DVRNL 289 Query: 401 VKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 + P +++++ PQ + +L P ER A ++ E+ +F+ L Sbjct: 290 --KFPLLFTQKY-PQEHMMVQDMLSPSPTER-----PEATDIIENAIFENL 332 >5EG3-A nrPDB Length = 334 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 59/239 (24%), Positives = 111/239 (46%), Gaps = 34/239 (14%) Query: 192 LGKGGFGEVCACQVRATGK-------MYACKKLEKKRIKKRKGEAMALNEKQILEKVNS- 243 LG+G FG+V + K A K L+ +K + ++ E ++++ + Sbjct: 43 LGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVS--EMEMMKMIGKH 100 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGF---------PEARAVFYAAE 294 + +++L A L +++ + G+L+ ++ G PE + F Sbjct: 101 KNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQMTFKDLV 160 Query: 295 ICC-----GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPE----GQTIKGR 345 C G+E L ++ ++RDL N+L+ ++ ++I+D GLA + +T GR Sbjct: 161 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDFFKETTNGR 220 Query: 346 VGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKE 403 + V +MAPE + + YT D W+ G L++E+ G SP+ I EE+ +L+KE Sbjct: 221 L-PVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY----PGIPVEELFKLLKE 274 >2HK5-A nrPDB Length = 270 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 97/213 (45%), Gaps = 19/213 (8%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMA----LNEKQ 236 + + + + + LG G FGEV M K K +K K +M+ L E Sbjct: 12 IPRESLKLEKKLGAGQFGEVW---------MATYNKHTKVAVKTMKPGSMSVEAFLAEAN 62 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 +++ + +V L +A TK+ + ++ M G L + + P + + ++A+I Sbjct: 63 VMKTLQHDKLVKL-HAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIA 121 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGT---VGYMA 353 G+ + + ++RDL+ NIL+ +I+D GLA V E R G + + A Sbjct: 122 EGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLA-RVIEDNEYTAREGAKFPIKWTA 180 Query: 354 PEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 PE + +T D W+ G LL E++ G+ P+ Sbjct: 181 PEAINFGSFTIKSDVWSFGILLMEIVTYGRIPY 213 >5XVU-A nrPDB Length = 332 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 41/128 (32%), Positives = 65/128 (50%), Gaps = 7/128 (5%) Query: 260 CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILL 319 L+ +N D K F + +Y +I L+ H + I++RD+KP NI++ Sbjct: 104 SLIFEYINNIDFK-----TLYPKFTDKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMI 158 Query: 320 D-DHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN-ERYTFSPDWWALGCLLYE 377 D ++ IR+ GLA GQ RV + Y PE++ + + Y +S D W+LGC+L Sbjct: 159 DHENRQIRLISWGLAEFYHPGQEYNVRVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAG 218 Query: 378 MIAGQSPF 385 MI + PF Sbjct: 219 MIFKKEPF 226 >3MIA-A nrPDB Length = 351 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 60/210 (28%), Positives = 96/210 (45%), Gaps = 18/210 (8%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 +G+G FGEV + R TG+ A KK+ + +K AL E +IL+ + VV+L Sbjct: 25 IGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITALREIKILQLLKHENVVNLIE 83 Query: 252 AYETK--------DALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 TK ++ LV + + E + V + GL +H Sbjct: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQM--LLNGLYYIH 141 Query: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIK-----GRVGTVGYMAPEVVK 358 R +I++RD+K N+L+ G ++++D GLA + + RV T+ Y PE++ Sbjct: 142 RNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLL 201 Query: 359 NERYTFSP-DWWALGCLLYEMIAGQSPFQQ 387 ER P D W GC++ EM +SP Q Sbjct: 202 GERDYGPPIDLWGAGCIMAEMWT-RSPIMQ 230 >1U59-A nrPDB Length = 287 Score = 66.2 bits (160), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 59/219 (26%), Positives = 107/219 (48%), Gaps = 15/219 (6%) Query: 192 LGKGGFGEVCACQVRATGK-MYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLA 250 LG G FG V R K + K+ K+ +K E M + E QI+ ++++ ++V L Sbjct: 18 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEM-MREAQIMHQLDNPYIVRLI 76 Query: 251 YAYETKDALCLVLTLMNGGDLKFHIYHMGQ-AGFPEARAVFYAAEICCGLEDLHRERIVY 309 + +AL LV+ + GG L H + +G+ P + ++ G++ L + V+ Sbjct: 77 GVCQA-EALMLVMEMAGGGPL--HKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 133 Query: 310 RDLKPENILLDDHGHIRISDLGL--AVHVPEGQTIKGRVGT--VGYMAPEVVKNERYTFS 365 RDL N+LL + + +ISD GL A+ + G + + APE + +++ Sbjct: 134 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 193 Query: 366 PDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKE 403 D W+ G ++E ++ GQ P+ KK+K EV +++ Sbjct: 194 SDVWSYGVTMWEALSYGQKPY----KKMKGPEVMAFIEQ 228 >2XYN-A nrPDB Length = 292 Score = 66.2 bits (160), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 51/227 (22%), Positives = 102/227 (44%), Gaps = 15/227 (6%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI 222 +++YF +W+ +ER +T LG G +GEV + A K L++ + Sbjct: 17 ENLYFQSMDKWE-MERTDITMK-----HKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTM 70 Query: 223 KKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG 282 + + L E +++++ +V L + +V M G+L ++ + Sbjct: 71 EVEE----FLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREE 126 Query: 283 FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI 342 ++ A +I +E L ++ ++RDL N L+ ++ ++++D GL+ + G T Sbjct: 127 VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLS-RLMTGDTY 185 Query: 343 KGRVGT---VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 G + + APE + ++ D WA G LL+E+ G SP+ Sbjct: 186 TAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPY 232 >2OZO-A nrPDB Length = 613 Score = 66.2 bits (160), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 58/219 (26%), Positives = 107/219 (48%), Gaps = 15/219 (6%) Query: 192 LGKGGFGEVCACQVRATGK-MYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLA 250 LG G FG V R K + K+ K+ +K E M + E QI+ ++++ ++V L Sbjct: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEM-MREAQIMHQLDNPYIVRLI 402 Query: 251 YAYETKDALCLVLTLMNGGDLKFHIYHMGQ-AGFPEARAVFYAAEICCGLEDLHRERIVY 309 + +AL LV+ + GG L H + +G+ P + ++ G++ L + V+ Sbjct: 403 GVCQA-EALMLVMEMAGGGPL--HKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 Query: 310 RDLKPENILLDDHGHIRISDLGL--AVHVPEGQTIKGRVGT--VGYMAPEVVKNERYTFS 365 R+L N+LL + + +ISD GL A+ + G + + APE + +++ Sbjct: 460 RNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 519 Query: 366 PDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKE 403 D W+ G ++E ++ GQ P+ KK+K EV +++ Sbjct: 520 SDVWSYGVTMWEALSYGQKPY----KKMKGPEVMAFIEQ 554 >4EBW-A nrPDB Length = 304 Score = 65.9 bits (159), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 47/211 (22%), Positives = 96/211 (45%), Gaps = 16/211 (7%) Query: 190 RVLGKGGFGEVCACQVRA------TGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 R +G+G FG+V + + CK ++++ L E + + + Sbjct: 44 RCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREK-----FLQEALTMRQFDH 98 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 +V L T++ + +++ L G+L+ + + + A + YA ++ L L Sbjct: 99 PHIVKLI-GVITENPVWIIMELCTLGELRSFL-QVRKYSLDLASLILYAYQLSTALAYLE 156 Query: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGT--VGYMAPEVVKNER 361 +R V+RD+ N+L+ + +++ D GL+ ++ + K G + +MAPE + R Sbjct: 157 SKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRR 216 Query: 362 YTFSPDWWALGCLLYEMIA-GQSPFQQRKKK 391 +T + D W G ++E++ G PFQ K Sbjct: 217 FTSASDVWMFGVCMWEILMHGVKPFQGVKNN 247 >5FM2-A nrPDB Length = 355 Score = 65.9 bits (159), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 61/228 (26%), Positives = 103/228 (45%), Gaps = 35/228 (15%) Query: 190 RVLGKGGFGEVCACQV-----RATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 + LG+G FG+V RA A K L++ + L+E +L++VN Sbjct: 70 KTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDL--LSEFNVLKQVNHP 127 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG----------------FPEARA 288 V+ L A L L++ G L+ + + G P+ RA Sbjct: 128 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 187 Query: 289 ------VFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI 342 + +A +I G++ L ++V+RDL NIL+ + ++ISD GL+ V E + Sbjct: 188 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 247 Query: 343 ----KGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 +GR+ V +MA E + + YT D W+ G LL+E++ G +P+ Sbjct: 248 VKRSQGRI-PVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPY 294 >3CJF-A nrPDB Length = 309 Score = 65.9 bits (159), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 53/213 (24%), Positives = 92/213 (43%), Gaps = 19/213 (8%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEA---MALNEKQILEKVNSRFVVS 248 LG+G FG+V K C+ + K +K+ + ++E +IL + V Sbjct: 35 LGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVV 94 Query: 249 LAYAYETKDA--LCLVLTLMNGGDLKFHIYHMGQAGFPEA----------RAVFYAAEIC 296 TK L +++ G+L ++ P + Y+ ++ Sbjct: 95 NLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEHLICYSFQVA 154 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA--VHVPEGQTIKGRVGT-VGYMA 353 G+E L + ++RDL NILL + ++I D GLA ++ KG + +MA Sbjct: 155 KGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMA 214 Query: 354 PEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 PE + + YT D W+ G LL+E+ + G SP+ Sbjct: 215 PETIFDRVYTIQSDVWSFGVLLWEIFSLGASPY 247 >3C1X-A nrPDB Length = 373 Score = 65.5 bits (158), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 52/202 (25%), Positives = 99/202 (49%), Gaps = 10/202 (4%) Query: 191 VLGKGGFGEVC-ACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 V+G+G FG V + GK C RI + L E I++ + V+SL Sbjct: 96 VIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL 155 Query: 250 -AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVF-YAAEICCGLEDLHRERI 307 ++ + +VL M GDL+ I + + P + + + ++ G++ L ++ Sbjct: 156 LGICLRSEGSPLVVLPYMKHGDLRNFIRN--ETHNPTVKDLIGFGLQVAKGMKFLASKKF 213 Query: 308 VYRDLKPENILLDDHGHIRISDLGLA--VHVPEGQTIKGRVGT---VGYMAPEVVKNERY 362 V+RDL N +LD+ ++++D GLA ++ E ++ + G V +MA E ++ +++ Sbjct: 214 VHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQTQKF 273 Query: 363 TFSPDWWALGCLLYEMIAGQSP 384 T D W+ G LL+E++ +P Sbjct: 274 TTKSDVWSFGVLLWELMTRGAP 295 >3DTC-A nrPDB Length = 271 Score = 65.5 bits (158), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 57/208 (27%), Positives = 95/208 (45%), Gaps = 18/208 (8%) Query: 191 VLGKGGFGEVC-ACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 ++G GGFG+V A + + A + + I + E ++ + +++L Sbjct: 14 IIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVR--QEAKLFAMLKHPNIIAL 71 Query: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIV- 308 + LCLV+ GG L + P V +A +I G+ LH E IV Sbjct: 72 RGVCLKEPNLCLVMEFARGGPLN---RVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVP 128 Query: 309 --YRDLKPENILL---DDHGHI-----RISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVK 358 +RDLK NIL+ ++G + +I+D GLA T G +MAPEV++ Sbjct: 129 IIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREW-HRTTKMSAAGAYAWMAPEVIR 187 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPFQ 386 ++ D W+ G LL+E++ G+ PF+ Sbjct: 188 ASMFSKGSDVWSYGVLLWELLTGEVPFR 215 >4TPT-A nrPDB Length = 303 Score = 65.1 bits (157), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 94/211 (44%), Gaps = 26/211 (12%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLA 250 VLGKG FG+ +ATGK+ K+L + + +K L E +++ ++ V+ Sbjct: 7 VLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQK---TFLTEVKVMRSLDHPNVLKFI 63 Query: 251 YAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYR 310 L L+ + GG LK + M FP + V +A I G+ LH I++R Sbjct: 64 GVLYKDKKLNLLTEYIEGGTLKDFLRSMDP--FPWQQKVRFAKGIASGMAYLHSMCIIHR 121 Query: 311 DLKPENILLDDHGHIRISDLGLAVHVPEGQ--------TIKGR-------------VGTV 349 DL N L+ + ++D GL+ + E + T K R VG Sbjct: 122 DLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNP 181 Query: 350 GYMAPEVVKNERYTFSPDWWALGCLLYEMIA 380 +MAPE++ + Y + D ++ G +L E+I Sbjct: 182 YWMAPEMLNGKSYDETVDIFSFGIVLCEIIG 212 >4PL5-B nrPDB Length = 435 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 57/173 (32%), Positives = 88/173 (50%), Gaps = 23/173 (13%) Query: 294 EICCGLEDLHRERIVYRDLKPENILL---DDHGHIR--ISDLGLAVHVPEGQTI----KG 344 + GL LH IV+RDLKP NILL + HG I+ ISD GL + G+ G Sbjct: 129 QTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSG 188 Query: 345 RVGTVGYMAPEVVK---NERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERL 400 GT G++APE++ + T++ D ++ GC+ Y +I+ G PF K ++R+ L Sbjct: 189 VPGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPF---GKSLQRQANILL 245 Query: 401 -VKEVPEEYSERFSPQ-ARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 + +S++ AR L +++ DP +R SA+ V +HP F L Sbjct: 246 GACNLDCFHSDKHEDVIARELIEKMIAMDPQQR-----PSAKHVLKHPFFWSL 293 >1FVR-A nrPDB Length = 327 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 58/223 (26%), Positives = 109/223 (48%), Gaps = 26/223 (11%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATG-KMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 N + V+G+G FG+V +++ G +M A K K+ K A E ++L K+ Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFA-GELEVLCKLG 83 Query: 243 SR-FVVSLAYAYETKDALCLVLTLMNGGDL--------------KFHIYHMGQAGFPEAR 287 +++L A E + L L + G+L F I + + + Sbjct: 84 HHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQ 143 Query: 288 AVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA----VHVPEGQTIK 343 + +AA++ G++ L +++ ++RDL NIL+ ++ +I+D GL+ V+V + Sbjct: 144 LLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYV---KKTM 200 Query: 344 GRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 GR+ V +MA E + YT + D W+ G LL+E+++ G +P+ Sbjct: 201 GRL-PVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPY 242 >4P5Q-A nrPDB Length = 361 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 58/228 (25%), Positives = 107/228 (46%), Gaps = 20/228 (8%) Query: 190 RVLGKGGFGEVCACQVRATGK---MYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFV 246 +V+G G FGEVC+ +++ K A K L+ +K++ + L E I+ + + + Sbjct: 39 KVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDF--LGEASIMGQFDHPNI 96 Query: 247 VSLAYAYETKDALCLVLTLMNGGDL-KFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 + L + +V M G L F H Q F + V I G++ L Sbjct: 97 IRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQ--FTVIQLVGMLRGIASGMKYLSDM 154 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHV---PEGQ-TIKGRVGTVGYMAPEVVKNER 361 V+RDL NIL++ + ++SD GL+ + PE T +G + + +PE + + Sbjct: 155 GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRK 214 Query: 362 YTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEY 408 +T + D W+ G +L+E+++ G+ P+ + + ++K V E Y Sbjct: 215 FTSASDVWSYGIVLWEVMSYGERPYWEMSN-------QDVIKAVDEGY 255 >2PSQ-A nrPDB Length = 370 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 59/239 (24%), Positives = 111/239 (46%), Gaps = 34/239 (14%) Query: 192 LGKGGFGEVCACQVRATGK-------MYACKKLEKKRIKKRKGEAMALNEKQILEKVNS- 243 LG+G FG+V + K A K L+ +K + ++ E ++++ + Sbjct: 89 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVS--EMEMMKMIGKH 146 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHI---------YHMGQAGFPEARAVFYAAE 294 + +++L A L +++ + G+L+ ++ Y PE + F Sbjct: 147 KNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLV 206 Query: 295 ICC-----GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPE----GQTIKGR 345 C G+E L ++ ++RDL N+L+ ++ ++I+D GLA + +T GR Sbjct: 207 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 266 Query: 346 VGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKE 403 + V +MAPE + + YT D W+ G L++E+ G SP+ I EE+ +L+KE Sbjct: 267 L-PVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY----PGIPVEELFKLLKE 320 >6BSD-A nrPDB Length = 876 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 77/301 (25%), Positives = 122/301 (40%), Gaps = 54/301 (17%) Query: 192 LGKGGFGEVCACQV----------------RATGKMYACKKLEKKRIKKRKGEAMALNEK 235 LG+G FGEV C+V + + A K L K + + L E Sbjct: 579 LGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDF--LKEV 636 Query: 236 QILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDL-KFHIYHM----------GQAGFP 284 +I+ ++ ++ L D LC++ M GDL +F H G Sbjct: 637 KIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAA 696 Query: 285 EARAVFY------AAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPE 338 + + Y AA+I G+ L V+RDL N L+ ++ I+I+D G++ ++ Sbjct: 697 QGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYA 756 Query: 339 GQ--TIKGR-VGTVGYMAPEVVKNERYTFSPDWWALGCLLYE--MIAGQSPFQQRKKKIK 393 G ++GR V + +MA E + ++T + D WA G L+E M+ PF Q Sbjct: 757 GDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTD--- 813 Query: 394 REEVERLVKEVPEEYSERFSPQARS--LCSQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 ++V E E F Q R L C L R S RE ++ P F +L Sbjct: 814 --------EQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWS-RESEQRPPFSQL 864 Query: 452 N 452 + Sbjct: 865 H 865 >4OW8-A nrPDB Length = 283 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 70/261 (26%), Positives = 113/261 (43%), Gaps = 28/261 (10%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKR------IKKRKGEAMALNEKQILE 239 +R R++ GG G+V G+ A K L+ + I++ + EA + Sbjct: 13 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEA------RTTA 66 Query: 240 KVNSRFVVSLAYAYETK-----DALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAE 294 +N + S+ E++ LV+ L+NG L + G+ A + + Sbjct: 67 MLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDML--EQ 124 Query: 295 ICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV---PEGQTIKGRV-GTVG 350 L+ H +V+RD+KP NIL+ G ++I+D G+A V P QT G V GT Sbjct: 125 TGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQT--GMVMGTAQ 182 Query: 351 YMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE 410 Y+APE + + D ++LG + YE ++G+ PF + +KE P Sbjct: 183 YIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTV---AMKHIKEPPPPLPP 239 Query: 411 RFSPQARSLCSQLLCKDPAER 431 P R L L K+PA R Sbjct: 240 DLPPNVRELIEITLVKNPAMR 260 >3TT0-A nrPDB Length = 382 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 59/238 (24%), Positives = 114/238 (47%), Gaps = 32/238 (13%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMA------LNEKQILEKVNS-R 244 LG+G FG+V + K ++ K +K K +A ++E ++++ + + Sbjct: 77 LGEGAFGQVVLAEAIGLDK-DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHK 135 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHI---------YHMGQAGFPEARA-----VF 290 +++L A L +++ + G+L+ ++ Y + PE + V Sbjct: 136 NIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVS 195 Query: 291 YAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPE----GQTIKGRV 346 A ++ G+E L ++ ++RDL N+L+ + ++I+D GLA + +T GR+ Sbjct: 196 CAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRL 255 Query: 347 GTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKE 403 V +MAPE + + YT D W+ G LL+E+ G SP+ + EE+ +L+KE Sbjct: 256 -PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY----PGVPVEELFKLLKE 308 >1AD5-A nrPDB Length = 438 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 53/213 (24%), Positives = 96/213 (45%), Gaps = 29/213 (13%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMA----LNEKQ 236 + + + + + LG G FGEV M K K +K K +M+ L E Sbjct: 179 IPRESLKLEKKLGAGQFGEVW---------MATYNKHTKVAVKTMKPGSMSVEAFLAEAN 229 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 +++ + +V L +A TK+ + ++ M G L + + P + + ++A+I Sbjct: 230 VMKTLQHDKLVKL-HAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIA 288 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGT---VGYMA 353 G+ + + ++RDL+ NIL+ +I+D GLA RVG + + A Sbjct: 289 EGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLA-----------RVGAKFPIKWTA 337 Query: 354 PEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 PE + +T D W+ G LL E++ G+ P+ Sbjct: 338 PEAINFGSFTIKSDVWSFGILLMEIVTYGRIPY 370 >3E3P-A nrPDB Length = 360 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 59/249 (23%), Positives = 111/249 (44%), Gaps = 12/249 (4%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKK-LEKKRIKKRKGEAMALNEK 235 ER + F+ R+ G+G FG V + ++TG A KK ++ R + R E + + Sbjct: 16 ERSRKEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRNR--ELQIMQDL 73 Query: 236 QILEKVNSRFVVSLAYAYETKDALCLVLTL-MNGGDLKFH----IYHMGQAGFPEARAVF 290 +L N + S Y +D + L + M H Y+ Q P Sbjct: 74 AVLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKV 133 Query: 291 YAAEICCGLEDLH--RERIVYRDLKPENILLDD-HGHIRISDLGLAVHVPEGQTIKGRVG 347 + ++ + LH + +RD+KP N+L+++ G +++ D G A + + + Sbjct: 134 FLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYIC 193 Query: 348 TVGYMAPEVV-KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPE 406 + Y APE++ N+ YT + D W++GC+ EM+ G+ F+ + E+ R++ Sbjct: 194 SRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSR 253 Query: 407 EYSERFSPQ 415 E + +P Sbjct: 254 EVLRKLNPS 262 >4JLC-A nrPDB Length = 657 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 52/212 (24%), Positives = 94/212 (44%), Gaps = 19/212 (8%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLA 250 +LG+G V + + TG +YA K I + + + E ++L+K+N + +V L Sbjct: 15 ILGQGATANVFRGRHKKTGDLYAVKVF--NNISFLRPVDVQMREFEVLKKLNHKNIVKL- 71 Query: 251 YAYE---TKDALCLVLTLMNGGDLKFHIYHMGQA-GFPEARAVFYAAEICCGLEDLHRER 306 +A E T L++ G L + A G PE+ + ++ G+ L Sbjct: 72 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 131 Query: 307 IVYRDLKPENILL----DDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVK---- 358 IV+RD+KP NI+ D +++D G A + + + GT Y+ P++ + Sbjct: 132 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 191 Query: 359 ----NERYTFSPDWWALGCLLYEMIAGQSPFQ 386 ++Y + D W++G Y G PF+ Sbjct: 192 RKDHQKKYGATVDLWSVGVTFYHAATGSLPFR 223 >3PPZ-A nrPDB Length = 309 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 53/199 (26%), Positives = 91/199 (45%), Gaps = 9/199 (4%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 +G G FG V + G A K L ++ + L E I++++ +V Sbjct: 45 IGAGSFGTVHRAEWH--GSDVAVKILMEQDFHAERVNEF-LREVAIMKRLRHPNIVLFMG 101 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQA--GFPEARAVFYAAEICCGLEDLHRER--I 307 A L +V ++ G L + + H A E R + A ++ G+ LH I Sbjct: 102 AVTQPPNLSIVTEYLSRGSL-YRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPI 160 Query: 308 VYRDLKPENILLDDHGHIRISDLGLA-VHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSP 366 V+RDLK N+L+D +++ D GL+ + + K GT +MAPEV+++E Sbjct: 161 VHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPSNEKS 220 Query: 367 DWWALGCLLYEMIAGQSPF 385 D ++ G +L+E+ Q P+ Sbjct: 221 DVYSFGVILWELATLQQPW 239 >6NPU-A nrPDB Length = 298 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 49/217 (22%), Positives = 97/217 (44%), Gaps = 15/217 (6%) Query: 174 KW-LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMAL 232 KW +ER +T LG G +GEV + A K L++ ++ + L Sbjct: 20 KWEMERTDITMK-----HKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEE----FL 70 Query: 233 NEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYA 292 E +++++ +V L + ++ M G+L ++ + ++ A Sbjct: 71 KEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMA 130 Query: 293 AEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGT---V 349 +I +E L ++ ++RDL N L+ ++ ++++D GL+ + G T G + Sbjct: 131 TQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLS-RLMTGDTYTAHAGAKFPI 189 Query: 350 GYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 + APE + +++ D WA G LL+E+ G SP+ Sbjct: 190 KWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPY 226 >3OZ6-A nrPDB Length = 388 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 69/295 (23%), Positives = 130/295 (44%), Gaps = 46/295 (15%) Query: 181 VTKNTFRQYRV---LGKGGFGEVCACQVRATGKMYACKKL-----EKKRIKKRKGEAMAL 232 V ++ R+Y + LGKG +G V R TG++ A KK+ ++ E M L Sbjct: 3 VDRHVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMIL 62 Query: 233 NEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPE-ARAVFY 291 E E + + ++++ A +D + LV M ++ + +A E + Sbjct: 63 TELSGHENIVN--LLNVLRADNDRD-VYLVFDYMETD-----LHAVIRANILEPVHKQYV 114 Query: 292 AAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA--------------VHVP 337 ++ ++ LH +++RD+KP NILL+ H++++D GL+ + + Sbjct: 115 VYQLIKVIKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSIN 174 Query: 338 EGQ--------TIKGRVGTVGYMAPEV-VKNERYTFSPDWWALGCLLYEMIAGQSPFQQR 388 E + V T Y APE+ + + +YT D W+LGC+L E++ G+ F Sbjct: 175 ENTENFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGS 234 Query: 389 KKKIKREEVERLVKEVPEEYSERF-SPQARSLCSQLLCKDPAERLGCRGGSAREV 442 + E + ++ E E SP A+++ L E++ R + R++ Sbjct: 235 STMNQLERIIGVIDFPSNEDVESIQSPFAKTMIESL-----KEKVEIRQSNKRDI 284 >2Y6O-A nrPDB Length = 291 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 50/204 (24%), Positives = 98/204 (48%), Gaps = 11/204 (5%) Query: 190 RVLGKGGFGEVCACQVRATGKMYAC---KKLEKKRIKKRKGEAMALNEKQILEKVNSRFV 246 +V+G G FGEVC+ +++ GK C K L+ K++ + L+E I+ + + + Sbjct: 20 KVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRD--FLSEASIMGQFDHPNI 77 Query: 247 VSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRER 306 + L + ++ M G L + F + V I G++ L Sbjct: 78 IHLEGVVTKCKPVMIITEYMENGSLDAFL-RKNDGRFTVIQLVGMLRGIGSGMKYLSDMS 136 Query: 307 IVYRDLKPENILLDDHGHIRISDLGLAVHV---PEGQ-TIKGRVGTVGYMAPEVVKNERY 362 V+RDL NIL++ + ++SD G++ + PE T +G + + APE + ++ Sbjct: 137 YVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKF 196 Query: 363 TFSPDWWALGCLLYEMIA-GQSPF 385 T + D W+ G +++E+++ G+ P+ Sbjct: 197 TSASDVWSYGIVMWEVMSYGERPY 220 >5U6B-A nrPDB Length = 307 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 54/217 (24%), Positives = 102/217 (47%), Gaps = 27/217 (12%) Query: 190 RVLGKGGFGEVCACQVR----------ATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 + LG+G FG V Q+ T K+ C + E ++ EA+ + E + Sbjct: 29 KTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSE---LEDFLSEAVCMKE---FD 82 Query: 240 KVNSRFVVSLAYAYETKDAL---CLVLTLMNGGDL-KFHIY-HMGQ--AGFPEARAVFYA 292 N ++ + + +++ ++L M GDL F +Y +G P V + Sbjct: 83 HPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFM 142 Query: 293 AEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIK-GRVGT--V 349 A+I G+E L +R ++RDL N +L+++ + ++D GL+ + G + GR+ V Sbjct: 143 ADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPV 202 Query: 350 GYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 ++A E + + YT D W+ G ++E+ GQ+P+ Sbjct: 203 KWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPY 239 >5H2U-A nrPDB Length = 267 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 50/205 (24%), Positives = 94/205 (45%), Gaps = 6/205 (2%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 + F R LG G FGEV + ++ A K + + + ++ M +E Q ++K+ Sbjct: 5 REEFTLCRKLGSGYFGEVFEGLWKDRVQV-AIKVISRDNLLHQQ---MLQSEIQAMKKLR 60 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 + +++L D + ++ LM G L + + P + + A ++ G+ L Sbjct: 61 HKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYL 120 Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGT-VGYMAPEVVKNER 361 + ++RDL NIL+ ++ ++ D GLA + E + + APE + Sbjct: 121 ESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGH 180 Query: 362 YTFSPDWWALGCLLYEMIA-GQSPF 385 Y+ D W+ G LL+EM + GQ P+ Sbjct: 181 YSTKSDVWSFGILLHEMFSRGQVPY 205 >3A4O-X nrPDB Length = 286 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 56/215 (26%), Positives = 102/215 (47%), Gaps = 16/215 (7%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 + + + + + LG G FGEV + K+ A K L+ + + L E +++ Sbjct: 10 IPRESIKLVKRLGAGQFGEVWMGYYNNSTKV-AVKTLKPGTMSVQA----FLEEANLMKT 64 Query: 241 VNSRFVVSLAYAYETKDALCLVLT--LMNGGDLKF-HIYHMGQAGFPEARAVFYAAEICC 297 + +V L YA T++ ++T + G L F G+ P + + ++A+I Sbjct: 65 LQHDKLVRL-YAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLP--KLIDFSAQIAE 121 Query: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGT---VGYMAP 354 G+ + R+ ++RDL+ N+L+ + +I+D GLA V E R G + + AP Sbjct: 122 GMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLA-RVIEDNEYTAREGAKFPIKWTAP 180 Query: 355 EVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQR 388 E + +T D W+ G LLYE++ G+ P+ R Sbjct: 181 EAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGR 215 >4Y83-A nrPDB Length = 332 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 65/253 (25%), Positives = 108/253 (42%), Gaps = 22/253 (8%) Query: 189 YRVLG-----KGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMA-LNEKQILEKVN 242 YR +G +G FG+V Q T K ACK + + K E A + I E Sbjct: 73 YRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACFRHENIAE--- 129 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 L A + + L + GG + + G E ++ + GL+ L Sbjct: 130 ------LYGAVLWGETVHLFMEAGEGGSVLEKLESCGP--MREFEIIWVTKHVLKGLDFL 181 Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI-KGRVGTVGYMAPEVVKNER 361 H +++++ D+KP NI+ + + D GL+V + E K GT YM+PEV+ Sbjct: 182 HSKKVIHHDIKPSNIVFMSTKAVLV-DFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRG 240 Query: 362 YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLV-KEVP--EEYSERFSPQARS 418 ++ D ++LG L M G P+ +R + ++ K+ P E+ ++ SP R Sbjct: 241 HSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRE 300 Query: 419 LCSQLLCKDPAER 431 L L ++P R Sbjct: 301 LIEASLERNPNHR 313 >3DLS-A nrPDB Length = 335 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 52/210 (24%), Positives = 97/210 (46%), Gaps = 11/210 (5%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKR------IKKRKGEAMALNEKQILEKVNSRF 245 LG G FG V + K K ++K++ I+ K + L E IL +V Sbjct: 32 LGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTL-EIAILSRVEHAN 90 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 ++ + +E + LV+ +G L + E A + ++ + L + Sbjct: 91 IIKVLDIFENQGFFQLVME-KHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLK 149 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFS 365 I++RD+K ENI++ + I++ D G A ++ G+ GT+ Y APEV+ Y Sbjct: 150 DIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYR-G 208 Query: 366 P--DWWALGCLLYEMIAGQSPFQQRKKKIK 393 P + W+LG LY ++ ++PF + ++ ++ Sbjct: 209 PELEMWSLGVTLYTLVFEENPFCELEETVE 238 >5A46-A nrPDB Length = 386 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 57/238 (23%), Positives = 111/238 (46%), Gaps = 32/238 (13%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMA------LNEKQILEKVNS-R 244 LG+G FG+V + K ++ K +K K +A ++E ++++ + + Sbjct: 48 LGEGCFGQVVLAEAIGLDKDKP-NRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHK 106 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLK--------------FHIYHMGQAGFPEARAVF 290 +++L A L +++ + G+L+ ++ H + V Sbjct: 107 NIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVS 166 Query: 291 YAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPE----GQTIKGRV 346 A ++ G+E L ++ ++RDL N+L+ + ++I+D GLA + +T GR+ Sbjct: 167 CAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRL 226 Query: 347 GTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKE 403 V +MAPE + + YT D W+ G LL+E+ G SP+ + EE+ +L+KE Sbjct: 227 -PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY----PGVPVEELFKLLKE 279 >4X3F-A nrPDB Length = 337 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 54/175 (30%), Positives = 81/175 (46%), Gaps = 11/175 (6%) Query: 261 LVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLD 320 LV+ L+NG L + G+ A + + L+ H +V+RD+KP NIL+ Sbjct: 94 LVMELVNGEPLNSVLKRTGRLSLRHALDMLE--QTGRALQIAHAAGLVHRDVKPGNILIT 151 Query: 321 DHGHIRISDLGLAVHV---PEGQTIKGRV-GTVGYMAPEVVKNERYTFSPDWWALGCLLY 376 G ++I+D G+A V P QT G V GT Y+APE + + D ++LG + Y Sbjct: 152 PTGQVKITDFGIAKAVDAAPVTQT--GMVMGTAQYIAPEQALGHDASPASDVYSLGVVGY 209 Query: 377 EMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 E ++G+ PF + +KE P P R L L K+PA R Sbjct: 210 EAVSGKRPFAGDGALTV---AMKHIKEPPPPLPPDLPPNVRELIEITLVKNPAMR 261 >2J0K-A nrPDB Length = 656 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 47/211 (22%), Positives = 95/211 (45%), Gaps = 16/211 (7%) Query: 190 RVLGKGGFGEVCACQVRA------TGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 R +G+G FG+V + + CK ++++ L E + + + Sbjct: 396 RCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREK-----FLQEALTMRQFDH 450 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 +V L T++ + +++ L G+L+ + + + A + YA ++ L L Sbjct: 451 PHIVKLI-GVITENPVWIIMELCTLGELRSFL-QVRKFSLDLASLILYAYQLSTALAYLE 508 Query: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGT--VGYMAPEVVKNER 361 +R V+RD+ N+L+ +++ D GL+ ++ + K G + +MAPE + R Sbjct: 509 SKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRR 568 Query: 362 YTFSPDWWALGCLLYEMIA-GQSPFQQRKKK 391 +T + D W G ++E++ G PFQ K Sbjct: 569 FTSASDVWMFGVCMWEILMHGVKPFQGVKNN 599 >3GQL-A nrPDB Length = 326 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 57/238 (23%), Positives = 111/238 (46%), Gaps = 32/238 (13%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMA------LNEKQILEKVNS-R 244 LG+G FG+V + K ++ K +K K +A ++E ++++ + + Sbjct: 36 LGEGAFGQVVLAEAIGLDK-DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHK 94 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLK--------------FHIYHMGQAGFPEARAVF 290 +++L A L +++ + G+L+ ++ H + V Sbjct: 95 NIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVS 154 Query: 291 YAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPE----GQTIKGRV 346 A ++ G+E L ++ ++RDL N+L+ + ++I+D GLA + +T GR+ Sbjct: 155 CAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRL 214 Query: 347 GTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKE 403 V +MAPE + + YT D W+ G LL+E+ G SP+ + EE+ +L+KE Sbjct: 215 -PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY----PGVPVEELFKLLKE 267 >3QGY-A nrPDB Length = 286 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 55/211 (26%), Positives = 95/211 (45%), Gaps = 13/211 (6%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKK-RKGEAMALNEKQILEKVNSRFVVSLA 250 +G G FG V G K+ K IK+ E + E +++ K++ +V L Sbjct: 35 IGSGQFGLV------HLGYWLNKDKVAIKTIKEGSMSEDDFIEEAEVMMKLSHPKLVQLY 88 Query: 251 YAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVF-YAAEICCGLEDLHRERIVY 309 + +CLV M G L Y Q G A + ++C G+ L +++ Sbjct: 89 GVCLEQAPICLVFEFMEHGCLS--DYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH 146 Query: 310 RDLKPENILLDDHGHIRISDLGLAVHVPEGQ--TIKGRVGTVGYMAPEVVKNERYTFSPD 367 RDL N L+ ++ I++SD G+ V + Q + G V + +PEV RY+ D Sbjct: 147 RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD 206 Query: 368 WWALGCLLYEMIA-GQSPFQQRKKKIKREEV 397 W+ G L++E+ + G+ P++ R E++ Sbjct: 207 VWSFGVLMWEVFSEGKIPYENRSNSEVVEDI 237 >6B2Q-A nrPDB Length = 317 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 70/261 (26%), Positives = 113/261 (43%), Gaps = 28/261 (10%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKR------IKKRKGEAMALNEKQILE 239 +R R++ GG G+V G+ A K L+ + I++ + EA + Sbjct: 34 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEA------RTTA 87 Query: 240 KVNSRFVVSLAYAYETK-----DALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAE 294 +N + S+ E++ LV+ L+NG L + G+ A + + Sbjct: 88 MLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDML--EQ 145 Query: 295 ICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV---PEGQTIKGRV-GTVG 350 L+ H +V+RD+KP NIL+ G ++I+D G+A V P QT G V GT Sbjct: 146 TGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQT--GMVMGTAQ 203 Query: 351 YMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE 410 Y+APE + + D ++LG + YE ++G+ PF + +KE P Sbjct: 204 YIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTV---AMKHIKEPPPPLPP 260 Query: 411 RFSPQARSLCSQLLCKDPAER 431 P R L L K+PA R Sbjct: 261 DLPPNVRELIEITLVKNPAMR 281 >4XEY-B nrPDB Length = 408 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 49/217 (22%), Positives = 97/217 (44%), Gaps = 15/217 (6%) Query: 174 KW-LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMAL 232 KW +ER +T LG G +GEV + A K L++ ++ + L Sbjct: 119 KWEMERTDITMK-----HKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEE----FL 169 Query: 233 NEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYA 292 E +++++ +V L + ++ M G+L ++ + ++ A Sbjct: 170 KEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMA 229 Query: 293 AEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGT---V 349 +I +E L ++ ++RDL N L+ ++ ++++D GL+ + G T G + Sbjct: 230 TQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLS-RLMTGDTYTAHAGAKFPI 288 Query: 350 GYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 + APE + +++ D WA G LL+E+ G SP+ Sbjct: 289 KWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPY 325 >3PP0-A nrPDB Length = 338 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 60/210 (28%), Positives = 96/210 (45%), Gaps = 16/210 (7%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMY----ACKKLEKKRIKKRKGEAMALNEKQILEKV 241 R+ +VLG G FG V G+ A K L + K E L+E ++ V Sbjct: 19 LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEI--LDEAYVMAGV 76 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIY-HMGQAGFPEARAVFYAAEICCGLE 300 S +V L T + LV LM G L H+ + G+ G + + + +I G+ Sbjct: 77 GSPYVSRLLGICLTS-TVQLVTQLMPYGCLLDHVRENRGRLGSQDL--LNWCMQIAKGMS 133 Query: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLA----VHVPEGQTIKGRVGTVGYMAPEV 356 L R+V+RDL N+L+ H++I+D GLA + E G+V + +MA E Sbjct: 134 YLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKV-PIKWMALES 192 Query: 357 VKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 + R+T D W+ G ++E++ G P+ Sbjct: 193 ILRRRFTHQSDVWSYGVTVWELMTFGAKPY 222 >5X5O-A nrPDB Length = 310 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 52/197 (26%), Positives = 90/197 (45%), Gaps = 15/197 (7%) Query: 193 GKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYA 252 G G FG V + + K A KKL K I+K E +IL ++ R ++ Sbjct: 24 GGGSFGSVYRAKWISQDKEVAVKKLLK--IEK---------EAEILSVLSHRNIIQFYGV 72 Query: 253 YETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE---RIVY 309 +V + G L +I + +A ++ G+ LH E ++++ Sbjct: 73 ILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIH 132 Query: 310 RDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWW 369 RDLK N+++ G ++I D G A T VGT +MAPEV+++ + + D + Sbjct: 133 RDLKSRNVVIAADGVLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTY 191 Query: 370 ALGCLLYEMIAGQSPFQ 386 + G +L+EM+ + PF+ Sbjct: 192 SYGVVLWEMLTREVPFK 208 >5WNL-A nrPDB Length = 342 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 52/213 (24%), Positives = 94/213 (44%), Gaps = 14/213 (6%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 F + +G GGFG+V + A K + R+ + L E + +E R+ Sbjct: 22 FAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMEL-LEEAKKMEMAKFRY 80 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH-- 303 ++ + Y ++ + LV+ M G L+ + P E G+ LH Sbjct: 81 ILPV-YGI-CQEPVGLVMEYMETGSLE---KLLASEPLPWDLRFRIVHETAVGMNFLHCM 135 Query: 304 RERIVYRDLKPENILLDDHGHIRISDLGLA----VHVPEGQTIKGRVGTVGYMAPEVVKN 359 +++ +LKP NILLD H H++ISD GLA + ++ G GT+ Y+ PE ++ Sbjct: 136 SPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIRE 195 Query: 360 ERYTFSP--DWWALGCLLYEMIAGQSPFQQRKK 390 + F D ++ +++ ++ + PF K Sbjct: 196 KSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKN 228 >6DBN-A nrPDB Length = 316 Score = 62.4 bits (150), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 51/221 (23%), Positives = 102/221 (46%), Gaps = 19/221 (8%) Query: 177 ERQPVT--------KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGE 228 E++P T K ++ R LG+G FG+V C+ G +++ K +K G Sbjct: 20 EKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG-EQVAVKSLKPESGG 78 Query: 229 AMALNEKQILEKVNSRFVVSLAY-----AYETKDALCLVLTLMNGGDLKFHIYHMGQAGF 283 + K+ +E + + + ++ + + + L++ + G LK ++ + Sbjct: 79 NHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYL-PKNKNKI 137 Query: 284 PEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV---PEGQ 340 + + YA +IC G++ L + V+RDL N+L++ ++I D GL + E Sbjct: 138 NLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYY 197 Query: 341 TIK-GRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA 380 T+K R V + APE + ++ + D W+ G L+E++ Sbjct: 198 TVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLT 238 >4Y93-A nrPDB Length = 446 Score = 62.4 bits (150), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 52/201 (25%), Positives = 97/201 (48%), Gaps = 13/201 (6%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKK-RKGEAMALNEKQILEKVNSRFVVSLA 250 LG G FG V GK + K IK+ E + E +++ ++ +V L Sbjct: 196 LGTGQFG------VVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQL- 248 Query: 251 YAYETKDALCLVLT-LMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 Y TK ++T M G L ++ M + F + + ++C +E L ++ ++ Sbjct: 249 YGVCTKQRPIFIITEYMANGCLLNYLREM-RHRFQTQQLLEMCKDVCEAMEYLESKQFLH 307 Query: 310 RDLKPENILLDDHGHIRISDLGLAVHV--PEGQTIKGRVGTVGYMAPEVVKNERYTFSPD 367 RDL N L++D G +++SD G+ +V E + G V + +PEV+ +++ D Sbjct: 308 RDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLMYSKFSSKSD 367 Query: 368 WWALGCLLYEMIA-GQSPFQQ 387 WA G L++E+ + G+ P+++ Sbjct: 368 IWAFGVLMWEIYSLGKMPYER 388 >5IKW-A nrPDB Length = 310 Score = 62.0 bits (149), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 53/168 (31%), Positives = 79/168 (47%), Gaps = 25/168 (14%) Query: 280 QAGFPEARAVFYAAEICCGLEDLHRER--IVYRDLKPENILLDDHGHIRISDLGLA---- 333 Q GF E + + C + LH+ + I++RDLK ENILL+D G+ + D G A Sbjct: 112 QTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKF 171 Query: 334 -------VHVPEGQTIKGRVGTVGYMAPEVVK---NERYTFSPDWWALGCLLYEMIAGQS 383 V+V E + IK + T+ Y APE++ + T D WALGCLLY++ Sbjct: 172 LNPQKDGVNVVE-EEIK-KYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTL 229 Query: 384 PFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 PF + + I +P+ + R+S L +L DP R Sbjct: 230 PFGESQVAICDGNF-----TIPD--NSRYSRNIHCLIRFMLEPDPEHR 270 >2FO0-A nrPDB Length = 495 Score = 62.0 bits (149), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 48/217 (22%), Positives = 97/217 (44%), Gaps = 15/217 (6%) Query: 174 KW-LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMAL 232 KW +ER +T LG G +GEV + A K L++ ++ + L Sbjct: 211 KWEMERTDITMK-----HKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEE----FL 261 Query: 233 NEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYA 292 E +++++ +V L + ++ M G+L ++ + ++ A Sbjct: 262 KEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMA 321 Query: 293 AEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGT---V 349 +I +E L ++ ++R+L N L+ ++ ++++D GL+ + G T G + Sbjct: 322 TQISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLS-RLMTGDTYTAHAGAKFPI 380 Query: 350 GYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 + APE + +++ D WA G LL+E+ G SP+ Sbjct: 381 KWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPY 417 >3KUL-B nrPDB Length = 325 Score = 62.0 bits (149), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 53/219 (24%), Positives = 103/219 (47%), Gaps = 15/219 (6%) Query: 190 RVLGKGGFGEVCACQVRATGKM---YACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFV 246 +++G G GEVC ++R G+ A K L+ ++++ + L+E I+ + + + Sbjct: 55 KIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDF--LSEASIMGQFDHPNI 112 Query: 247 VSLAYAYETKDALCLVLT--LMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 + L T+ L +++T + NG F H GQ F + V + G+ L Sbjct: 113 IRLE-GVVTRGRLAMIVTEYMENGSLDTFLRTHDGQ--FTIMQLVGMLRGVGAGMRYLSD 169 Query: 305 ERIVYRDLKPENILLDDHGHIRISDLGLAVHVPE----GQTIKGRVGTVGYMAPEVVKNE 360 V+RDL N+L+D + ++SD GL+ + + T G + + APE + Sbjct: 170 LGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFR 229 Query: 361 RYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVE 398 ++ + D W+ G +++E++A G+ P+ + VE Sbjct: 230 TFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVE 268 >4EUU-A nrPDB Length = 319 Score = 61.6 bits (148), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 53/235 (22%), Positives = 103/235 (43%), Gaps = 19/235 (8%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 Q + + + +LG+G V + + TG ++A K I + + + E ++L Sbjct: 4 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVF--NNISFLRPVDVQMREFEVL 61 Query: 239 EKVNSRFVVSLAYAYE---TKDALCLVLTLMNGGDLKFHIYHMGQA-GFPEARAVFYAAE 294 +K+N + +V L +A E T L++ G L + A G PE+ + + Sbjct: 62 KKLNHKNIVKL-FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRD 120 Query: 295 ICCGLEDLHRERIVYRDLKPENILL----DDHGHIRISDLGLAVHVPEGQTIKGRVGTVG 350 + G+ L IV+R++KP NI+ D +++D G A + + + GT Sbjct: 121 VVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE 180 Query: 351 YMAPEVVK--------NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEV 397 Y+ P++ + ++Y + D W++G Y G PF+ + + +EV Sbjct: 181 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEV 235 >6NT9-A nrPDB Length = 742 Score = 61.6 bits (148), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 50/212 (23%), Positives = 94/212 (44%), Gaps = 19/212 (8%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLA 250 +LG+G V + + TG ++A K I + + + E ++L+K+N + +V L Sbjct: 14 ILGQGATANVFRGRHKKTGDLFAIKVF--NNISFLRPVDVQMREFEVLKKLNHKNIVKL- 70 Query: 251 YAYE---TKDALCLVLTLMNGGDLKFHIYHMGQA-GFPEARAVFYAAEICCGLEDLHRER 306 +A E T L++ G L + A G PE+ + ++ G+ L Sbjct: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 Query: 307 IVYRDLKPENILL----DDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVK---- 358 IV+R++KP NI+ D +++D G A + + + GT Y+ P++ + Sbjct: 131 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 190 Query: 359 ----NERYTFSPDWWALGCLLYEMIAGQSPFQ 386 ++Y + D W++G Y G PF+ Sbjct: 191 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 222 >2PVN-A nrPDB Length = 352 Score = 61.6 bits (148), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 49/198 (24%), Positives = 84/198 (42%), Gaps = 41/198 (20%) Query: 290 FYAAEICCGLEDLHRERIVYRDLKPENILLDDH-GHIRISDLGLAVHVPEGQTIKGRVGT 348 +Y E+ L+ H + I++RD+KP N+++D +R+ D GLA G+ RV + Sbjct: 150 YYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVAS 209 Query: 349 VGYMAPEVVKN-ERYTFSPDWWALGCLLYEMIAGQSPF---------------------- 385 + PE++ + + Y +S D W+LGC+ MI + PF Sbjct: 210 RYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGL 269 Query: 386 ------------QQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLG 433 Q + + R + +K + + SP+A +LL D ERL Sbjct: 270 NAYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERL- 328 Query: 434 CRGGSAREVKEHPLFKKL 451 +A E HP F+++ Sbjct: 329 ----TALEAMTHPYFQQV 342 >5MJB-A nrPDB Length = 305 Score = 61.6 bits (148), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 50/206 (24%), Positives = 99/206 (48%), Gaps = 15/206 (7%) Query: 191 VLGKGGFGEVCACQVRATGK---MYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVV 247 V+G G FGEV +++ GK A K L+ +K++ + L+E I+ + + R ++ Sbjct: 33 VIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDF--LSEASIMGQFDHRNII 90 Query: 248 SLAYAYETKDALCLVLTLMNGGDL-KFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRER 306 L + ++ M L F + GQ F + V I G++ L Sbjct: 91 RLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQ--FTVIQLVGMLRGIAAGMKYLSEMN 148 Query: 307 IVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVG------YMAPEVVKNE 360 V+RDL NIL++ + ++SD GL+ ++ + + ++G + APE + Sbjct: 149 YVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYR 208 Query: 361 RYTFSPDWWALGCLLYEMIA-GQSPF 385 ++T + D W+ G +++E+++ G+ P+ Sbjct: 209 KFTSASDVWSYGIVMWEVMSFGERPY 234 >4EUT-A nrPDB Length = 396 Score = 61.6 bits (148), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 50/212 (23%), Positives = 94/212 (44%), Gaps = 19/212 (8%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLA 250 +LG+G V + + TG ++A K I + + + E ++L+K+N + +V L Sbjct: 16 ILGQGATANVFRGRHKKTGDLFAIKVF--NNISFLRPVDVQMREFEVLKKLNHKNIVKL- 72 Query: 251 YAYE---TKDALCLVLTLMNGGDLKFHIYHMGQA-GFPEARAVFYAAEICCGLEDLHRER 306 +A E T L++ G L + A G PE+ + ++ G+ L Sbjct: 73 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 132 Query: 307 IVYRDLKPENILL----DDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVK---- 358 IV+R++KP NI+ D +++D G A + + + GT Y+ P++ + Sbjct: 133 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVL 192 Query: 359 ----NERYTFSPDWWALGCLLYEMIAGQSPFQ 386 ++Y + D W++G Y G PF+ Sbjct: 193 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 224 >3GC0-A nrPDB Length = 329 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 51/202 (25%), Positives = 93/202 (46%), Gaps = 13/202 (6%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 +R+ LG+G +GEV T + A K++ + ++ A+ E +L+++ R Sbjct: 36 YRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEH-EEEGVPGTAIREVSLLKELQHRN 94 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 ++ L L L+ DLK ++ ++ Y ++ G+ H Sbjct: 95 IIELKSVIHHNHRLHLIFEYAEN-DLKKYMDKNPDVSMRVIKSFLY--QLINGVNFCHSR 151 Query: 306 RIVYRDLKPENILL-----DDHGHIRISDLGL--AVHVPEGQTIKGRVGTVGYMAPEVVK 358 R ++RDLKP+N+LL + ++I D GL A +P Q + T+ Y PE++ Sbjct: 152 RCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQ-FTHEIITLWYRPPEILL 210 Query: 359 NER-YTFSPDWWALGCLLYEMI 379 R Y+ S D W++ C+ EM+ Sbjct: 211 GSRHYSTSVDIWSIACIWAEML 232 >5L6P-A nrPDB Length = 298 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 47/205 (22%), Positives = 96/205 (46%), Gaps = 13/205 (6%) Query: 191 VLGKGGFGEVCACQVRATGK---MYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVV 247 V+G G FGEVC +++ G+ A K L+ ++++ + L+E I+ + + ++ Sbjct: 26 VIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDF--LSEASIMGQFDHPNII 83 Query: 248 SLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERI 307 L + ++ M L + + F + V I G++ L Sbjct: 84 RLEGVVTKSRPVMILTEFMENCALDSFL-RLNDGQFTVIQLVGMLRGIAAGMKYLSEMNY 142 Query: 308 VYRDLKPENILLDDHGHIRISDLGLAVHV---PEGQTIKGRVGT---VGYMAPEVVKNER 361 V+RDL NIL++ + ++SD GL+ + P T +G + + APE + + Sbjct: 143 VHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRK 202 Query: 362 YTFSPDWWALGCLLYEMIA-GQSPF 385 +T + D W+ G +++E+++ G+ P+ Sbjct: 203 FTSASDVWSYGIVMWEVMSYGERPY 227 >1LUF-A nrPDB Length = 343 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 59/254 (23%), Positives = 102/254 (40%), Gaps = 41/254 (16%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATG-------KMYACKKLEKKRIKKRKGEAMALNEK 235 +N R +G+G FG V Q RA G M A K L+++ + + E Sbjct: 46 RNNIEYVRDIGEGAFGRVF--QARAPGLLPYEPFTMVAVKMLKEEASADMQADFQ--REA 101 Query: 236 QILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHM----------------- 278 ++ + ++ +V L +CL+ M GDL + M Sbjct: 102 ALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRA 161 Query: 279 -----GQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA 333 G A + A ++ G+ L + V+RDL N L+ ++ ++I+D GL+ Sbjct: 162 RVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLS 221 Query: 334 VHVPEGQTIKGRVGT---VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRK 389 ++ K + +M PE + RYT D WA G +L+E+ + G P+ Sbjct: 222 RNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYY--- 278 Query: 390 KKIKREEVERLVKE 403 + EEV V++ Sbjct: 279 -GMAHEEVIYYVRD 291 >6O8B-A nrPDB Length = 665 Score = 60.8 bits (146), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 50/212 (23%), Positives = 94/212 (44%), Gaps = 19/212 (8%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLA 250 +LG+G V + + TG ++A K I + + + E ++L+K+N + +V L Sbjct: 22 ILGQGATANVFRGRHKKTGDLFAIKVF--NNISFLRPVDVQMREFEVLKKLNHKNIVKL- 78 Query: 251 YAYE---TKDALCLVLTLMNGGDLKFHIYHMGQA-GFPEARAVFYAAEICCGLEDLHRER 306 +A E T L++ G L + A G PE+ + ++ G+ L Sbjct: 79 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 138 Query: 307 IVYRDLKPENILL----DDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVK---- 358 IV+R++KP NI+ D +++D G A + + + GT Y+ P++ + Sbjct: 139 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYERAVL 198 Query: 359 ----NERYTFSPDWWALGCLLYEMIAGQSPFQ 386 ++Y + D W++G Y G PF+ Sbjct: 199 RKDHQKKYGATVDLWSIGVTFYHAATGSLPFR 230 >4H1J-A nrPDB Length = 293 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 49/202 (24%), Positives = 92/202 (45%), Gaps = 10/202 (4%) Query: 190 RVLGKGGFGEV---CACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFV 246 R+LG+G FGEV + A K +K K + M+ E I++ ++ + Sbjct: 30 RILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMS--EAVIMKNLDHPHI 87 Query: 247 VSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRER 306 V L E ++ +++ L G+L H + V Y+ +IC + L Sbjct: 88 VKLIGIIE-EEPTWIIMELYPYGELG-HYLERNKNSLKVLTLVLYSLQICKAMAYLESIN 145 Query: 307 IVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVG--TVGYMAPEVVKNERYTF 364 V+RD+ NIL+ +++ D GL+ ++ + K V + +M+PE + R+T Sbjct: 146 CVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTT 205 Query: 365 SPDWWALGCLLYEMIA-GQSPF 385 + D W ++E+++ G+ PF Sbjct: 206 ASDVWMFAVCMWEILSFGKQPF 227 >5O0Y-A nrPDB Length = 579 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 62/233 (26%), Positives = 107/233 (45%), Gaps = 22/233 (9%) Query: 223 KKRKGEAMALNEKQILEKVNSRFVVSL-AYAYETKDALCLVLTLMNGGDLKFHIYHMGQA 281 KK A E +I ++++ +V L Y D+ C VL G DL F++ Sbjct: 327 KKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLM 386 Query: 282 GFPEARAVFYAAEICCGLEDLHRER--IVYRDLKPENILLDDH---GHIRISDLGLA--- 333 EAR++ +I L+ L+ + I++ DLKP NILL + G I+I+D GL+ Sbjct: 387 SEKEARSII--MQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIM 444 Query: 334 ----VHVPEGQTIKGR-VGTVGYMAPE--VVKNE--RYTFSPDWWALGCLLYEMIAGQSP 384 + +G + + GT Y+ PE VV E + + D W++G + Y+ + G+ P Sbjct: 445 DDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKP 504 Query: 385 F--QQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCR 435 F Q ++ I +E EV +P+A++ + L +R+ + Sbjct: 505 FGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQ 557 >5CEK-A nrPDB Length = 263 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 52/190 (27%), Positives = 88/190 (46%), Gaps = 20/190 (10%) Query: 269 GDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILL--DDHGHIR 326 GD+ H Y + E A +I + H+ IV DLK + ++ +R Sbjct: 85 GDM--HSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLR 142 Query: 327 ISDLGLAVHVPEGQ--TIKGRVGTVGYMAPEVVKNERYTFS---PDWWALGCLLYEMIAG 381 + L H+ +G+ + + G Y++PE++ N T+S D W+LG +LY ++ G Sbjct: 143 LESLE-DTHIMKGEDDALSDKHGCPAYVSPEIL-NTTGTYSGKAADVWSLGVMLYTLLVG 200 Query: 382 QSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSARE 441 + PF ++ R +PE SP+AR L LL ++P+ERL +A E Sbjct: 201 RYPFHDSDPSALFSKIRRGQFCIPEH----ISPKARCLIRSLLRREPSERL-----TAPE 251 Query: 442 VKEHPLFKKL 451 + HP F+ + Sbjct: 252 ILLHPWFESV 261 >3PG1-A nrPDB Length = 362 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 72/280 (25%), Positives = 107/280 (38%), Gaps = 18/280 (6%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMA--------LNEKQILEKV 241 R + G +G VCA V + G A K++ R ++ L E ++L Sbjct: 28 RFISSGSYGAVCAG-VDSEGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRLLNHF 86 Query: 242 NSRFVVSL-----AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 + ++ L + L LV LM DL + H + ++ I Sbjct: 87 HHPNILGLRDIFVHFEEPAMHKLYLVTELMRT-DLA-QVIHDQRIVISPQHIQYFMYHIL 144 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 GL LH +V+RDL P NILL D+ I I D LA V Y APE+ Sbjct: 145 LGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHRWYRAPEL 204 Query: 357 VKNER-YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERF-SP 414 V + +T D W+ GC++ EM ++ F+ + ++ +V E F SP Sbjct: 205 VMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVVMFSSP 264 Query: 415 QARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFK 454 AR L PA +A V + K L F Sbjct: 265 SARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFN 304 >3M42-A nrPDB Length = 299 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 65/264 (24%), Positives = 106/264 (40%), Gaps = 36/264 (13%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 +VLG G G+V + T + +A K L+ +R+ E + Q V R V Sbjct: 24 QVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVE-LHWRASQCPHIV--RIVDVY 80 Query: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 Y + L +V+ ++GG+L I G F E A I ++ LH I + Sbjct: 81 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 140 Query: 310 RDLKPENILLDD---HGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSP 366 RD+KPEN+L + ++++D G A T G E+Y S Sbjct: 141 RDVKPENLLYTSKRPNAILKLTDFGFAKE------------TTG---------EKYDKSC 179 Query: 367 DWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVK----EVPEEYSERFSPQARSLCSQ 422 D W+LG ++Y ++ G PF ++ ++ E P S + + L Sbjct: 180 DMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRN 239 Query: 423 LLCKDPAERLGCRGGSAREVKEHP 446 LL +P +R+ + E HP Sbjct: 240 LLKTEPTQRM-----TITEFMNHP 258 >6DC0-A nrPDB Length = 292 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 52/190 (27%), Positives = 88/190 (46%), Gaps = 20/190 (10%) Query: 269 GDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILL--DDHGHIR 326 GD+ H Y + E A +I + H+ IV DLK + ++ +R Sbjct: 82 GDM--HSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLR 139 Query: 327 ISDLGLAVHVPEGQ--TIKGRVGTVGYMAPEVVKNERYTFS---PDWWALGCLLYEMIAG 381 + L H+ +G+ + + G Y++PE++ N T+S D W+LG +LY ++ G Sbjct: 140 LESLE-DTHIMKGEDDALSDKHGCPAYVSPEIL-NTTGTYSGKAADVWSLGVMLYTLLVG 197 Query: 382 QSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSARE 441 + PF ++ R +PE SP+AR L LL ++P+ERL +A E Sbjct: 198 RYPFHDSDPSALFSKIRRGQFCIPEH----ISPKARCLIRSLLRREPSERL-----TAPE 248 Query: 442 VKEHPLFKKL 451 + HP F+ + Sbjct: 249 ILLHPWFESV 258 >1U5R-A nrPDB Length = 348 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 61/249 (24%), Positives = 97/249 (38%), Gaps = 10/249 (4%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 F R +G G FG V + ++ A KK+ + + + E + L+K+ Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 115 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 + Y + LV+ G H E AV + A GL LH Sbjct: 116 TIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGA--LQGLAYLHSH 173 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVV---KNERY 362 +++RD+K NILL + G +++ D G A + + VGT +MAPEV+ +Y Sbjct: 174 NMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSF---VGTPYWMAPEVILAMDEGQY 230 Query: 363 TFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQ 422 D W+LG E+ + P + + E P S +S R+ Sbjct: 231 DGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQ--NESPALQSGHWSEYFRNFVDS 288 Query: 423 LLCKDPAER 431 L K P +R Sbjct: 289 CLQKIPQDR 297 >2GCD-A nrPDB Length = 309 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 61/249 (24%), Positives = 97/249 (38%), Gaps = 10/249 (4%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 F R +G G FG V + ++ A KK+ + + + E + L+K+ Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 76 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 + Y + LV+ G H E AV + A GL LH Sbjct: 77 TIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGA--LQGLAYLHSH 134 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVV---KNERY 362 +++RD+K NILL + G +++ D G A + + VGT +MAPEV+ +Y Sbjct: 135 NMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSF---VGTPYWMAPEVILAMDEGQY 191 Query: 363 TFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQ 422 D W+LG E+ + P + + E P S +S R+ Sbjct: 192 DGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQ--NESPALQSGHWSEYFRNFVDS 249 Query: 423 LLCKDPAER 431 L K P +R Sbjct: 250 CLQKIPQDR 258 >4M66-A nrPDB Length = 325 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 57/228 (25%), Positives = 98/228 (42%), Gaps = 17/228 (7%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 V++ ++ +GKGGFG V R A K + K+I + L + +L Sbjct: 17 VSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISWEVKAMVNLRNENVLLL 76 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 + V+ ++ LV M G L + +A P E+ G+ Sbjct: 77 LG----VTEDLQWDFVSGQALVTRFMENGSLAGLL--QPEAPRPWPLLCRLLQEVVLGMC 130 Query: 301 DLHR--ERIVYRDLKPENILLDDHGHIRISDLGLAVH-------VPEGQTIKGRVGTVGY 351 LH +++RDLKP NILLD H +++D GL+ G + GT+ Y Sbjct: 131 YLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAY 190 Query: 352 MAPEVV--KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEV 397 + PE++ N + + + D ++ G L++ ++AG+ K + RE V Sbjct: 191 LDPELLFKVNLKASKASDVYSFGILVWAVLAGREAELVDKTSLIRETV 238 >6BFN-A nrPDB Length = 342 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 59/241 (24%), Positives = 102/241 (42%), Gaps = 28/241 (11%) Query: 173 WKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKL-EKKRIKKRKGEAMA 231 W E T N F + +G+GGFG V +R T +YA K+L E ++ + Sbjct: 12 WPLCEISRGTHN-FSEELKIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSF 68 Query: 232 LNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQA----GFPEAR 287 L E + L + +V A CLV + G L+ ++ QA +P+ Sbjct: 69 LTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRL 128 Query: 288 AVFYAAEICCGLEDLHRER--IVYRDLKPENILLDDHGHIRISDLGLA------------ 333 + ++ LH++ +++ D+K N+LLD+ ++ D GLA Sbjct: 129 DILLGTAR--AIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQ 186 Query: 334 -VHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKI 392 V QT++G T+ Y+ E +K R D ++ G ++ E +AGQ + + Sbjct: 187 SSMVARTQTVRG---TLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGART 243 Query: 393 K 393 K Sbjct: 244 K 244 >4AT3-A nrPDB Length = 299 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 59/231 (25%), Positives = 99/231 (42%), Gaps = 27/231 (11%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQV-----RATGKMYACKKLEKKRIKKRKGEAMALN 233 Q + ++ R LG+G FG+V + + A K L+ RK Sbjct: 8 QHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFH---R 64 Query: 234 EKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDL-KFHIYH------MGQAGFP-- 284 E ++L + +V D L +V M GDL KF H M + P Sbjct: 65 EAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTE 124 Query: 285 --EARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI 342 +++ + A +I G+ L + V+RDL N L+ ++ ++I D G++ V T Sbjct: 125 LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYS--TD 182 Query: 343 KGRVGT-----VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQ 387 RVG + +M PE + ++T D W+LG +L+E+ G+ P+ Q Sbjct: 183 YYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQ 233 >3ZBF-A nrPDB Length = 322 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 57/215 (26%), Positives = 91/215 (42%), Gaps = 22/215 (10%) Query: 191 VLGKGGFGEV---CACQVRATGK---MYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 +LG G FGEV A + G A K L+K + K E L E ++ K N Sbjct: 40 LLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEF--LKEAHLMSKFNHP 97 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGF-----PEARAVFYAAEICCGL 299 ++ + ++L LM GGDL ++ A F V +I G Sbjct: 98 NILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGC 157 Query: 300 EDLHRERIVYRDLKPENILLDDHGH-----IRISDLGLAVHVPEGQTIKGR---VGTVGY 351 L R ++RDL N L+ + ++I D GLA + + + R + V + Sbjct: 158 VYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRW 217 Query: 352 MAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 MAPE + + +T D W+ G L++E++ G P+ Sbjct: 218 MAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPY 252 >3KRL-A nrPDB Length = 335 Score = 59.7 bits (143), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 57/233 (24%), Positives = 104/233 (44%), Gaps = 26/233 (11%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKR----KGEAMAL 232 E+ +N + + LG G FG+V GK A K+ K +K + EA+ + Sbjct: 39 EKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEAL-M 97 Query: 233 NEKQILEKVNSRFVVSLAYAYETKDALCLVLT-------LMN--------GGDLKFHIYH 277 +E +I+ + + T LV+T L+N G + ++ H Sbjct: 98 SELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSH 157 Query: 278 MGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHI-RISDLGLA--V 334 + + +++++ G+ L + ++RD+ N+LL + GH+ +I D GLA + Sbjct: 158 NPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTN-GHVAKIGDFGLARDI 216 Query: 335 HVPEGQTIKGRVGT-VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 +KG V +MAPE + + YT D W+ G LL+E+ + G +P+ Sbjct: 217 MNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPY 269 >3SXS-A nrPDB Length = 268 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 52/199 (26%), Positives = 92/199 (46%), Gaps = 13/199 (6%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKK-RKGEAMALNEKQILEKVNSRFVVSLA 250 LG G FG V GK + K IK+ E E Q + K++ +V Sbjct: 16 LGSGQFG------VVKLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFY 69 Query: 251 YAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYR 310 + + +V ++ G L ++ G+ G ++ + ++C G+ L + ++R Sbjct: 70 GVCSKEYPIYIVTEYISNGCLLNYLRSHGK-GLEPSQLLEMCYDVCEGMAFLESHQFIHR 128 Query: 311 DLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGT---VGYMAPEVVKNERYTFSPD 367 DL N L+D +++SD G+ +V + Q + VGT V + APEV +Y+ D Sbjct: 129 DLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSS-VGTKFPVKWSAPEVFHYFKYSSKSD 187 Query: 368 WWALGCLLYEMIA-GQSPF 385 WA G L++E+ + G+ P+ Sbjct: 188 VWAFGILMWEVFSLGKMPY 206 >4CRL-A nrPDB Length = 406 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 60/222 (27%), Positives = 98/222 (44%), Gaps = 26/222 (11%) Query: 192 LGKGGFGEV--CACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 +G+G +G V + K YA K++E I A E +L ++ V+SL Sbjct: 30 VGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGI-----SMSACREIALLRELKHPNVISL 84 Query: 250 AYAYETK-DALCLVLTLMNGGDLKFHIYHMGQAG--------FPEARAVFYAAEICCGLE 300 + + D +L DL +HI +A P +I G+ Sbjct: 85 QKVFLSHADRKVWLLFDYAEHDL-WHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIH 143 Query: 301 DLHRERIVYRDLKPENILL----DDHGHIRISDLGLA----VHVPEGQTIKGRVGTVGYM 352 LH +++RDLKP NIL+ + G ++I+D+G A + + V T Y Sbjct: 144 YLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYR 203 Query: 353 APEVVKNER-YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIK 393 APE++ R YT + D WA+GC+ E++ + F R++ IK Sbjct: 204 APELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIK 245 >3SOC-A nrPDB Length = 322 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 38/103 (36%), Positives = 61/103 (59%), Gaps = 8/103 (7%) Query: 286 ARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT---I 342 AR + Y E GL+D H+ I +RD+K +N+LL ++ I+D GLA+ G++ Sbjct: 131 ARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDT 190 Query: 343 KGRVGTVGYMAPEVVKN----ERYTF-SPDWWALGCLLYEMIA 380 G+VGT YMAPEV++ +R F D +A+G +L+E+ + Sbjct: 191 HGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELAS 233 >6E4F-A nrPDB Length = 290 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 53/202 (26%), Positives = 99/202 (49%), Gaps = 15/202 (7%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKK-RKGEAMALNEKQILEKVNSRFVVSLA 250 LG G FG V GK + K IK+ E + E +++ ++ +V L Sbjct: 39 LGTGQFG------VVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQL- 91 Query: 251 YAYETKDALCLVLT-LMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 Y TK ++T M G L ++ M + F + + ++C +E L ++ ++ Sbjct: 92 YGVCTKQRPIFIITEYMANGCLLNYLREM-RHRFQTQQLLEMCKDVCEAMEYLESKQFLH 150 Query: 310 RDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGT---VGYMAPEVVKNERYTFSP 366 RDL N L++D G +++SD GL+ +V + + VG+ V + PEV+ +++ Sbjct: 151 RDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSS-VGSKFPVRWSPPEVLMYSKFSSKS 209 Query: 367 DWWALGCLLYEMIA-GQSPFQQ 387 D WA G L++E+ + G+ P+++ Sbjct: 210 DIWAFGVLMWEIYSLGKMPYER 231 >3AOX-A nrPDB Length = 344 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 60/226 (26%), Positives = 92/226 (40%), Gaps = 15/226 (6%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKK---RKGEAMALNEKQI 237 V + R LG G FGEV QV + ++ K + + + E L E I Sbjct: 44 VPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALI 103 Query: 238 LEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHM-GQAGFPEARAVF----YA 292 + K N + +V ++L LM GGDLK + + P + A+ A Sbjct: 104 ISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVA 163 Query: 293 AEICCGLEDLHRERIVYRDLKPENILLDDHGHIR---ISDLGLAVHVPEGQTI-KGRVGT 348 +I CG + L ++RD+ N LL G R I D G+A + KG Sbjct: 164 RDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAM 223 Query: 349 --VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKK 391 V +M PE +T D W+ G LL+E+ + G P+ + + Sbjct: 224 LPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQ 269 >5U6C-A nrPDB Length = 315 Score = 59.3 bits (142), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 53/226 (23%), Positives = 99/226 (43%), Gaps = 17/226 (7%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVR---ATGKMYACKKLEKKRIKKRKGEAMAL 232 LE + +N ++LG+G FG V ++ T A K ++ +R+ E L Sbjct: 28 LEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEF-L 86 Query: 233 NEKQILEKVNSRFV-----VSLAYAYETKDALCLVLTLMNGGDLKFHIYH----MGQAGF 283 +E ++ + V V + + + ++L M GDL ++ + G Sbjct: 87 SEAACMKDFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHI 146 Query: 284 PEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIK 343 P + + +I G+E L ++RDL N +L D + ++D GL+ + G + Sbjct: 147 PLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYR 206 Query: 344 -GRVGT--VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 GR+ V ++A E + + YT D WA G ++E+ G +P+ Sbjct: 207 QGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPY 252 >2OGV-A nrPDB Length = 317 Score = 59.3 bits (142), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 65/257 (25%), Positives = 119/257 (46%), Gaps = 23/257 (8%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKR----KGEAMAL 232 E+ +N + + LG G FG+V GK A K+ K +K + EA+ + Sbjct: 31 EKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEAL-M 89 Query: 233 NEKQILEKVNSR-FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQA------GFP- 284 +E +I+ + +V+L A + ++ GDL + +A G P Sbjct: 90 SELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPL 149 Query: 285 EARAVF-YAAEICCGLEDLHRERIVYRDLKPENILLDDHGHI-RISDLGLA--VHVPEGQ 340 E R + +++++ G+ L + ++RD+ N+LL + GH+ +I D GLA + Sbjct: 150 ELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTN-GHVAKIGDFGLARDIMNDSNY 208 Query: 341 TIKGRVGT-VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVE 398 +KG V +MAPE + + YT D W+ G LL+E+ + G +P+ + + Sbjct: 209 IVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPY---PGILVNSKFY 265 Query: 399 RLVKEVPEEYSERFSPQ 415 +LVK+ + F+P+ Sbjct: 266 KLVKDGYQMAQPAFAPK 282 >3RP9-A nrPDB Length = 458 Score = 58.9 bits (141), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 53/226 (23%), Positives = 92/226 (40%), Gaps = 44/226 (19%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEK--------KRIKKRKGEAMALNEKQILEKVN 242 ++G G +G VC + ++ A KK+ + KRI + LN +++ ++ Sbjct: 60 LIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNRLNHDHVVKVLD 119 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 + + E D L +VL + D F E + G++ + Sbjct: 120 ----IVIPKDVEKFDELYVVLEI---ADSDFKKLFRTPVYLTELHIKTLLYNLLVGVKYV 172 Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLA------------------------VHVPE 338 H I++RDLKP N L++ +++ D GLA V P Sbjct: 173 HSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVTFPH 232 Query: 339 GQTIK----GRVGTVGYMAPE-VVKNERYTFSPDWWALGCLLYEMI 379 + +K G V T Y APE ++ E YT + D W++GC+ E++ Sbjct: 233 TKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELL 278 >6GQK-A nrPDB Length = 328 Score = 58.9 bits (141), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 56/220 (25%), Positives = 94/220 (42%), Gaps = 26/220 (11%) Query: 190 RVLGKGGFGEVCACQ----VRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV-NSR 244 + LG G FG+V +++ M K+ K + EA+ ++E ++L + N Sbjct: 47 KTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREAL-MSELKVLSYLGNHE 105 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARA--------------VF 290 +V+L A ++ GDL + P A + Sbjct: 106 NIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLTLEHLLS 165 Query: 291 YAAEICCGLEDLHRERIVYRDLKPENILLDDHGHI-RISDLGLAVHVPEGQTIKGRVGT- 348 ++ ++ G+ L + ++RDL NILL HG+I +I D GLA + + Sbjct: 166 FSYQVAKGMAFLASKNCIHRDLAARNILLT-HGNITKICDFGLARDIKNDSNYVDKGNAR 224 Query: 349 --VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 V +MAPE + N YTF D W+ G L+E+ + G SP+ Sbjct: 225 LPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPY 264 >4XI2-A nrPDB Length = 446 Score = 58.5 bits (140), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 52/202 (25%), Positives = 99/202 (49%), Gaps = 15/202 (7%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKK-RKGEAMALNEKQILEKVNSRFVVSLA 250 LG G FG V GK + K I++ E + E +++ ++ +V L Sbjct: 195 LGTGQFG------VVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHEKLVQL- 247 Query: 251 YAYETKDALCLVLT-LMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 Y TK ++T M G L ++ M + F + + ++C +E L ++ ++ Sbjct: 248 YGVCTKQRPIFIITEYMANGCLLNYLREM-RHRFQTQQLLEMCKDVCEAMEYLESKQFLH 306 Query: 310 RDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGT---VGYMAPEVVKNERYTFSP 366 RDL N L++D G +++SD GL+ +V + + VG+ V + PEV+ +++ Sbjct: 307 RDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSS-VGSKFPVRWSPPEVLMYSKFSSKS 365 Query: 367 DWWALGCLLYEMIA-GQSPFQQ 387 D WA G L++E+ + G+ P+++ Sbjct: 366 DIWAFGVLMWEIYSLGKMPYER 387 >3VHK-A nrPDB Length = 368 Score = 58.5 bits (140), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 33/101 (32%), Positives = 55/101 (54%), Gaps = 4/101 (3%) Query: 289 VFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA--VHVPEGQTIKGRV 346 + Y+ ++ G+E L + ++RDL NILL + ++I D GLA ++ KG Sbjct: 203 ICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDA 262 Query: 347 GT-VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 + +MAPE + + YT D W+ G LL+E+ + G SP+ Sbjct: 263 RLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPY 303 >4PDO-A nrPDB Length = 299 Score = 58.2 bits (139), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 54/206 (26%), Positives = 97/206 (47%), Gaps = 14/206 (6%) Query: 190 RVLGKGGFGEVCACQVR-ATGKM---YACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 +V+G G FGEV ++ ++GK A K L+ +K++ + L E I+ + + Sbjct: 40 KVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDF--LGEAGIMGQFSHHN 97 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDL-KFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 ++ L + ++ M G L KF G+ F + V I G++ L Sbjct: 98 IIRLEGVISKYKPMMIITEYMENGALDKFLREKDGE--FSVLQLVGMLRGIAAGMKYLAN 155 Query: 305 ERIVYRDLKPENILLDDHGHIRISDLGLAVHV---PEGQ-TIKGRVGTVGYMAPEVVKNE 360 V+RDL NIL++ + ++SD GL+ + PE T G + + APE + Sbjct: 156 MNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYR 215 Query: 361 RYTFSPDWWALGCLLYE-MIAGQSPF 385 ++T + D W+ G +++E M G+ P+ Sbjct: 216 KFTSASDVWSFGIVMWEVMTYGERPY 241 >3HNG-A nrPDB Length = 360 Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 31/101 (30%), Positives = 57/101 (56%), Gaps = 4/101 (3%) Query: 289 VFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGT 348 + Y+ ++ G+E L + ++RDL NILL ++ ++I D GLA + + + T Sbjct: 202 ISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDT 261 Query: 349 ---VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 + +MAPE + ++ Y+ D W+ G LL+E+ + G SP+ Sbjct: 262 RLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPY 302 >4LFI-A nrPDB Length = 374 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 32/98 (32%), Positives = 52/98 (53%), Gaps = 2/98 (2%) Query: 290 FYAAEICCGLEDLHRERIVYRDLKPENILLDD-HGHIRISDLGLAVHVPEGQTIKGRVGT 348 FY E+ L+ H I++RD+KP N+++D + +R+ D GLA RV + Sbjct: 176 FYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVAS 235 Query: 349 VGYMAPEVVKNER-YTFSPDWWALGCLLYEMIAGQSPF 385 + PE++ + R Y +S D W+ G +L MI + PF Sbjct: 236 RFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 273 >5GNK-A nrPDB Length = 297 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 57/210 (27%), Positives = 95/210 (45%), Gaps = 16/210 (7%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMY----ACKKLEKKRIKKRKGEAMALNEKQILEKV 241 F++ +VLG G FG V G+ A K+L + K E L+E ++ V Sbjct: 21 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEI--LDEAYVMASV 78 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIY-HMGQAGFPEARAVFYAAEICCGLE 300 ++ V L T + L++ LM G L ++ H G + + +I G+ Sbjct: 79 DNPHVCRLLGICLT-STVQLIMQLMPFGCLLDYVREHKDNIG--SQYLLNWCVQIAKGMN 135 Query: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLA----VHVPEGQTIKGRVGTVGYMAPEV 356 L R+V+RDL N+L+ H++I+D GLA E G+V + +MA E Sbjct: 136 YLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKV-PIKWMALES 194 Query: 357 VKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 + + YT D W+ G ++E++ G P+ Sbjct: 195 ILHRIYTHQSDVWSYGVTVWELMTFGSKPY 224 >3BEA-A nrPDB Length = 333 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 61/261 (23%), Positives = 115/261 (44%), Gaps = 27/261 (10%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKR----KGEAMAL 232 E+ +N + + LG G FG+V GK A K+ K +K + EA+ + Sbjct: 39 EKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEAL-M 97 Query: 233 NEKQILEKVNSRFVVSLAYAYETKDALCLVLT-------LMNGGDLKFHI------YHMG 279 +E +I+ + + T LV+T L+N K + + + Sbjct: 98 SELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIA 157 Query: 280 QAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHI-RISDLGLA--VHV 336 + + +++++ G+ L + ++RD+ N+LL + GH+ +I D GLA + Sbjct: 158 NSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTN-GHVAKIGDFGLARDIMN 216 Query: 337 PEGQTIKGRVGT-VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKR 394 +KG V +MAPE + + YT D W+ G LL+E+ + G +P+ + Sbjct: 217 DSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPY---PGILVN 273 Query: 395 EEVERLVKEVPEEYSERFSPQ 415 + +LVK+ + F+P+ Sbjct: 274 SKFYKLVKDGYQMAQPAFAPK 294 >3ZZW-A nrPDB Length = 289 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 31/101 (30%), Positives = 54/101 (53%), Gaps = 4/101 (3%) Query: 289 VFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIK---GR 345 V A+I G+E L +V++DL N+L+ D +++ISDLGL V K Sbjct: 131 VHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNS 190 Query: 346 VGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 + + +MAPE + +++ D W+ G +L+E+ + G P+ Sbjct: 191 LLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPY 231 >5GRN-A nrPDB Length = 356 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 63/268 (23%), Positives = 107/268 (39%), Gaps = 45/268 (16%) Query: 150 HEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATG 209 HEY+ V P +Q + R ++ RVLG G FG+V Sbjct: 25 HEYIYVDP-------------MQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLS 71 Query: 210 KMYACKKLEKKRIK--KRKGEAMAL-NEKQILEKVNSRF-VVSLAYAYETKDALCLVLTL 265 + K+ K +K R E AL +E +I+ + +V+L A + ++ Sbjct: 72 RSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEY 131 Query: 266 MNGGDLKFHIY--------HMGQA----------------GFPEARAVFYAAEICCGLED 301 GDL +++ H ++ G + + ++ G+E Sbjct: 132 CFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEF 191 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGT---VGYMAPEVVK 358 L + V+RDL N+LL ++I D GLA + + T V +MAPE + Sbjct: 192 LASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIF 251 Query: 359 NERYTFSPDWWALGCLLYEMIA-GQSPF 385 + YT D W+ G LL+E+ + G +P+ Sbjct: 252 DNLYTTLSDVWSYGILLWEIFSLGGTPY 279 >3PLS-A nrPDB Length = 298 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 51/203 (25%), Positives = 90/203 (44%), Gaps = 10/203 (4%) Query: 190 RVLGKGGFGEVCACQ-VRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVS 248 RV+GKG FG V + + C RI + + L E ++ +N V++ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLA 86 Query: 249 LAYAYETKDAL-CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERI 307 L + L ++L M GDL Q + + ++ G+E L ++ Sbjct: 87 LIGIMLPPEGLPHVLLPYMCHGDL-LQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKF 145 Query: 308 VYRDLKPENILLDDHGHIRISDLGLAVHVPE------GQTIKGRVGTVGYMAPEVVKNER 361 V+RDL N +LD+ ++++D GLA + + Q R+ V + A E ++ R Sbjct: 146 VHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARL-PVKWTALESLQTYR 204 Query: 362 YTFSPDWWALGCLLYEMIAGQSP 384 +T D W+ G LL+E++ +P Sbjct: 205 FTTKSDVWSFGVLLWELLTRGAP 227 >4R7H-A nrPDB Length = 343 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 63/270 (23%), Positives = 117/270 (43%), Gaps = 36/270 (13%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKR----KGEAMAL 232 E+ +N + + LG G FG+V GK A K+ K +K + EA+ + Sbjct: 43 EKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEAL-M 101 Query: 233 NEKQILEKVNSR-FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGF-------- 283 +E +I+ + +V+L A + ++ GDL + +A Sbjct: 102 SELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQ 161 Query: 284 -PEA------------RAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHI-RISD 329 PE + +++++ G+ L + ++RD+ N+LL + GH+ +I D Sbjct: 162 DPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTN-GHVAKIGD 220 Query: 330 LGLA--VHVPEGQTIKGRVGT-VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 GLA + +KG V +MAPE + + YT D W+ G LL+E+ + G +P+ Sbjct: 221 FGLARDIMNDSNYIVKGNARLPVKWMAPESIFDSVYTVQSDVWSYGILLWEIFSLGLNPY 280 Query: 386 QQRKKKIKREEVERLVKEVPEEYSERFSPQ 415 + + +LVK+ + F+P+ Sbjct: 281 ---PGILVNSKFYKLVKDGYQMAQPAFAPK 307 >3LZB-A nrPDB Length = 327 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 90/209 (43%), Gaps = 14/209 (6%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMY----ACKKLEKKRIKKRKGEAMALNEKQILEKV 241 F++ +VLG G FG V G+ A K+L + K E L+E ++ V Sbjct: 17 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEI--LDEAYVMASV 74 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 ++ V L T + + G L + H G + + +I G+ Sbjct: 75 DNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIG--SQYLLNWCVQIAKGMNY 132 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLA----VHVPEGQTIKGRVGTVGYMAPEVV 357 L R+V+RDL N+L+ H++I+D GLA E G+V + +MA E + Sbjct: 133 LEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKV-PIKWMALESI 191 Query: 358 KNERYTFSPDWWALGCLLYEMIA-GQSPF 385 + YT D W+ G ++E++ G P+ Sbjct: 192 LHRIYTHQSDVWSYGVTVWELMTFGSKPY 220 >4XCU-A nrPDB Length = 300 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 42/130 (32%), Positives = 69/130 (53%), Gaps = 12/130 (9%) Query: 279 GQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA--VHV 336 G FP + Y ++ G++ L + ++RDL N+L+ + ++I+D GLA VH Sbjct: 125 GPLSFPVLVSCAY--QVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHH 182 Query: 337 PE--GQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIK 393 + +T GR+ V +MAPE + + YT D W+ G LL+E+ G SP+ I Sbjct: 183 IDYYKKTSNGRL-PVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPY----PGIP 237 Query: 394 REEVERLVKE 403 EE+ L++E Sbjct: 238 VEELFSLLRE 247 >2I6L-A nrPDB Length = 320 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 49/206 (23%), Positives = 87/206 (42%), Gaps = 37/206 (17%) Query: 280 QAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHI-RISDLGLAVHVPE 338 Q E A + ++ GL+ +H +++RDLKP N+ ++ + +I D GLA + Sbjct: 114 QGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDP 173 Query: 339 GQTIKGRVG----TVGYMAPEVVKN-ERYTFSPDWWALGCLLYEMIAGQSPFQ------- 386 + KG + T Y +P ++ + YT + D WA GC+ EM+ G++ F Sbjct: 174 HYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQ 233 Query: 387 -----QRKKKIKREEVERLVKEVP----EEYSERFSP----------QARSLCSQLLCKD 427 + + E+ + L+ +P + +E P +A Q+L Sbjct: 234 MQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFS 293 Query: 428 PAERLGCRGGSAREVKEHPLFKKLNF 453 P +RL +A E HP +F Sbjct: 294 PMDRL-----TAEEALSHPYMSIYSF 314 >3NIE-A nrPDB Length = 429 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 61/251 (24%), Positives = 101/251 (40%), Gaps = 51/251 (20%) Query: 168 NRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEK-------- 219 N + Q ++ V N + ++G+G +G V + K A KK+ + Sbjct: 13 NLYFQGAIIKNVKVPDN-YEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDC 71 Query: 220 KRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDAL----CLVLTLMNGGDLKFHI 275 KRI L E IL ++ S +++ L +D L ++ + DLK Sbjct: 72 KRI---------LREITILNRLKSDYIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLF 122 Query: 276 YHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA-- 333 + + Y + G + +H I++RDLKP N LL+ ++I D GLA Sbjct: 123 KTPIFLTEQHVKTILY--NLLLGEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLART 180 Query: 334 ------VHV--------------PEGQTIK----GRVGTVGYMAPE-VVKNERYTFSPDW 368 +H+ P + +K V T Y APE ++ E YT S D Sbjct: 181 INSDKDIHIVNDLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDI 240 Query: 369 WALGCLLYEMI 379 W+ GC+ E++ Sbjct: 241 WSTGCIFAELL 251 >3G0E-A nrPDB Length = 336 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 36/100 (36%), Positives = 54/100 (54%), Gaps = 6/100 (6%) Query: 291 YAAEICCGLEDLHRERIVYRDLKPENILLDDHGHI-RISDLGLA--VHVPEGQTIKGRVG 347 ++ ++ G+ L + ++RDL NILL HG I +I D GLA + +KG Sbjct: 173 FSYQVAKGMAFLASKNCIHRDLAARNILLT-HGRITKICDFGLARDIKNDSNYVVKGNAR 231 Query: 348 T-VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 V +MAPE + N YTF D W+ G L+E+ + G SP+ Sbjct: 232 LPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPY 271 >3BBT-B nrPDB Length = 328 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 91/209 (43%), Gaps = 14/209 (6%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMY----ACKKLEKKRIKKRKGEAMALNEKQILEKV 241 ++ +VLG G FG V G+ A K L + K E M +E I+ + Sbjct: 17 LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFM--DEALIMASM 74 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 + +V L + LV LM G L ++ H + + + +I G+ Sbjct: 75 DHPHLVRL-LGVCLSPTIQLVTQLMPHGCLLEYV-HEHKDNIGSQLLLNWCVQIAKGMMY 132 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQ----TIKGRVGTVGYMAPEVV 357 L R+V+RDL N+L+ H++I+D GLA + EG G + +MA E + Sbjct: 133 LEERRLVHRDLAARNVLVKSPNHVKITDFGLA-RLLEGDEKEYNADGGKMPIKWMALECI 191 Query: 358 KNERYTFSPDWWALGCLLYEMIA-GQSPF 385 ++T D W+ G ++E++ G P+ Sbjct: 192 HYRKFTHQSDVWSYGVTIWELMTFGGKPY 220 >4F0G-A nrPDB Length = 287 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 70/277 (25%), Positives = 122/277 (44%), Gaps = 44/277 (15%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ---- 236 + N + +GKGGFG V ++ + A K L + +GE + + Q Sbjct: 16 LADNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSL---ILGDSEGETEMIEKFQEFQR 72 Query: 237 ---ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYH-MGQAGFPEARAV--F 290 I+ +N +V L Y + +V+ + GDL YH + P +V Sbjct: 73 EVFIMSNLNHPNIVKL-YGL-MHNPPRMVMEFVPCGDL----YHRLLDKAHPIKWSVKLR 126 Query: 291 YAAEICCGLEDLHRER--IVYRDLKPENILL---DDHGHI--RISDLGLA---VHVPEGQ 340 +I G+E + + IV+RDL+ NI L D++ + +++D GL+ VH Sbjct: 127 LMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVH----- 181 Query: 341 TIKGRVGTVGYMAPEVV--KNERYTFSPDWWALGCLLYEMIAGQSPFQQ----RKKKIKR 394 ++ G +G +MAPE + + E YT D ++ +LY ++ G+ PF + + K I Sbjct: 182 SVSGLLGNFQWMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINM 241 Query: 395 EEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 E L +PE+ P+ R++ DP +R Sbjct: 242 IREEGLRPTIPED----CPPRLRNVIELCWSGDPKKR 274 >4HZS-A nrPDB Length = 341 Score = 55.8 bits (133), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 53/213 (24%), Positives = 88/213 (41%), Gaps = 10/213 (4%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRA-TGKMY--ACKKLEKKRIKKRKGEAMALNEKQI 237 + + R LG G FG V + A +GK A K L+ + + + + E Sbjct: 9 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 68 Query: 238 LEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 + ++ R ++ L Y + +V L G L Q F YA ++ Sbjct: 69 MHSLDHRNLIRL-YGVVLTPPMKMVTELAPLGSL-LDRLRKHQGHFLLGTLSRYAVQVAE 126 Query: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQ----TIKGRVGTVGYMA 353 G+ L +R ++RDL N+LL ++I D GL +P+ + R + A Sbjct: 127 GMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCA 186 Query: 354 PEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 PE +K ++ + D W G L+EM GQ P+ Sbjct: 187 PESLKTRTFSHASDTWMFGVTLWEMFTYGQEPW 219 >1U54-B nrPDB Length = 291 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 53/213 (24%), Positives = 89/213 (41%), Gaps = 10/213 (4%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRA-TGKMY--ACKKLEKKRIKKRKGEAMALNEKQI 237 + + R LG G FG V + A +GK A K L+ + + + + E Sbjct: 15 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 74 Query: 238 LEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 + ++ R ++ L Y + +V L G L + Q F YA ++ Sbjct: 75 MHSLDHRNLIRL-YGVVLTPPMKMVTELAPLGSLLDRL-RKHQGHFLLGTLSRYAVQVAE 132 Query: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQ----TIKGRVGTVGYMA 353 G+ L +R ++RDL N+LL ++I D GL +P+ + R + A Sbjct: 133 GMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCA 192 Query: 354 PEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 PE +K ++ + D W G L+EM GQ P+ Sbjct: 193 PESLKTRTFSHASDTWMFGVTLWEMFTYGQEPW 225 >3V5Q-A nrPDB Length = 297 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 61/223 (27%), Positives = 95/223 (42%), Gaps = 30/223 (13%) Query: 190 RVLGKGGFGEV----CACQVRATGKM-YACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 R LG+G FG+V C KM A K L+ + RK E ++L + Sbjct: 21 RELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQ---REAELLTNLQHE 77 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDL-KFHIYHMGQA-----GFPE--------ARAVF 290 +V D L +V M GDL KF H A G P ++ + Sbjct: 78 HIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLH 137 Query: 291 YAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGT-- 348 A++I G+ L + V+RDL N L+ + ++I D G++ V T RVG Sbjct: 138 IASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYS--TDYYRVGGHT 195 Query: 349 ---VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQ 387 + +M PE + ++T D W+ G +L+E+ G+ P+ Q Sbjct: 196 MLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQ 238 >3N9X-A nrPDB Length = 432 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 56/226 (24%), Positives = 90/226 (39%), Gaps = 47/226 (20%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEK--------KRIKKRKGEAMALNEKQILEKV 241 ++G+G +G V + T K A KK+ + KRI L E IL ++ Sbjct: 32 HLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRI---------LREITILNRL 82 Query: 242 NSRFVVSLAYAYETKDAL----CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 S +++ L D L ++ + DLK + + Y + Sbjct: 83 KSDYIIRLYDLIIPDDLLKFDELYIVLEIADSDLKKLFKTPIFLTEEHIKTILY--NLLL 140 Query: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV-------------------PE 338 G +H I++RDLKP N LL+ +++ D GLA + P Sbjct: 141 GENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPH 200 Query: 339 GQTIK----GRVGTVGYMAPE-VVKNERYTFSPDWWALGCLLYEMI 379 + +K V T Y APE ++ E YT S D W+ GC+ E++ Sbjct: 201 NKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELL 246 >2JD5-A nrPDB Length = 373 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 54/229 (23%), Positives = 98/229 (42%), Gaps = 27/229 (11%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 +P + R LG G F V + A K + ++ E +E ++L Sbjct: 14 EPYKDARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAE----DEIKLL 69 Query: 239 EKVN-----------SRFVVSLAYAYETK--DALCLVLTL-MNGGDLKFHIYHMGQAGFP 284 ++VN + ++ L + K + + +V+ + G +L I G P Sbjct: 70 QRVNDADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIP 129 Query: 285 EARAVFYAAEICCGLEDLHRE-RIVYRDLKPENILLD------DHGHIRISDLGLAVHVP 337 + ++ GL+ +HR I++ D+KPEN+L++ + I+I+DLG A Sbjct: 130 LIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYD 189 Query: 338 EGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQ 386 E T + T Y +PEV+ + D W+ CL++E+I G F+ Sbjct: 190 EHYT--NSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFE 236 >4XUF-A nrPDB Length = 297 Score = 55.1 bits (131), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 58/225 (25%), Positives = 97/225 (43%), Gaps = 29/225 (12%) Query: 190 RVLGKGGFGEV---CACQVRATG-KMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 +VLG G FG+V A + TG + K+ K++ + EA+ K + + + Sbjct: 15 KVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHEN 74 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDL---------KF---HIYHMGQAGFPEAR------ 287 +V+L A + L+ GDL KF I + Q E Sbjct: 75 IVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLNVLT 134 Query: 288 ---AVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA--VHVPEGQTI 342 + +A ++ G+E L + V+RDL N+L+ ++I D GLA + + Sbjct: 135 FEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVV 194 Query: 343 KGRVGT-VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 +G V +MAPE + YT D W+ G LL+E+ + G +P+ Sbjct: 195 RGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPY 239 >5X02-A nrPDB Length = 347 Score = 55.1 bits (131), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 58/225 (25%), Positives = 97/225 (43%), Gaps = 29/225 (12%) Query: 190 RVLGKGGFGEV---CACQVRATG-KMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 +VLG G FG+V A + TG + K+ K++ + EA+ K + + + Sbjct: 54 KVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHEN 113 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDL---------KF---HIYHMGQAGFPEAR------ 287 +V+L A + L+ GDL KF I + Q E Sbjct: 114 IVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLNVLT 173 Query: 288 ---AVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA--VHVPEGQTI 342 + +A ++ G+E L + V+RDL N+L+ ++I D GLA + + Sbjct: 174 FEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVV 233 Query: 343 KGRVGT-VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 +G V +MAPE + YT D W+ G LL+E+ + G +P+ Sbjct: 234 RGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPY 278 >5XD6-A nrPDB Length = 305 Score = 55.1 bits (131), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 58/227 (25%), Positives = 99/227 (43%), Gaps = 25/227 (11%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 E + +T N + ++G+G +G V ++ +GK A KKL+ + + + L + Sbjct: 16 ELRDITDN-YGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSK----QPDQEFLAQVS 69 Query: 237 ILEKVNSRFVVSL-AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARA------- 288 ++ ++ VV+L Y D VL + H G+ G A+ Sbjct: 70 MVSRLRQENVVALLGYCV---DGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWH 126 Query: 289 --VFYAAEICCGLEDLHRE---RIVYRDLKPENILLDDHGHIRISDLGLAVHVPE--GQT 341 V A GLE LH + +++RD+K N+LL D +I+D L+ P+ + Sbjct: 127 QRVKIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARL 186 Query: 342 IKGRV-GTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQ 387 RV GT GY APE + D ++ G +L E++ G+ P Sbjct: 187 HSTRVLGTFGYHAPEYAMTGTLSTKSDVYSFGVVLLELLTGRKPVDH 233 >5AR8-A nrPDB Length = 326 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 51/218 (23%), Positives = 89/218 (40%), Gaps = 30/218 (13%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 R L +G G V + + A K L L E +IL K +++ + Sbjct: 38 RYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPI 97 Query: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQ---AGFPEARAVFYAAEICCGLEDLHRER 306 + L +V M G L ++ + +P + + EI G+ LH Sbjct: 98 LGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILH--EIALGVNYLHNMT 155 Query: 307 --IVYRDLKPENILLDDHGHIRISDLGLA-------------VHVPEGQTIKGRVGTVGY 351 +++ DLK +NILLD+ H++I+D GL+ PEG GT+ Y Sbjct: 156 PPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEG-------GTIIY 208 Query: 352 MAPEVV---KNERYTFSPDWWALGCLLYEMIAGQSPFQ 386 M PE + R + D ++ + +E+++ + PF+ Sbjct: 209 MPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFE 246 >3MY0-A nrPDB Length = 305 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 64/214 (29%), Positives = 87/214 (40%), Gaps = 40/214 (18%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR------F 245 +GKG +GEV + G+ A K I + E E +I V R F Sbjct: 16 VGKGRYGEVW--RGLWHGESVAVK------IFSSRDEQSWFRETEIYNTVLLRHDNILGF 67 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEAR-AVFYAAEICCGLEDLHR 304 + S + + L L+ G L Y Q E A+ A CGL LH Sbjct: 68 IASDMTSRNSSTQLWLITHYHEHGSL----YDFLQRQTLEPHLALRLAVSAACGLAHLHV 123 Query: 305 E--------RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI-----KGRVGTVGY 351 E I +RD K N+L+ + I+DLGLAV +G RVGT Y Sbjct: 124 EIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRY 183 Query: 352 MAPEVVKN-------ERYTFSPDWWALGCLLYEM 378 MAPEV+ E Y ++ D WA G +L+E+ Sbjct: 184 MAPEVLDEQIRTDCFESYKWT-DIWAFGLVLWEI 216 >4FL3-A nrPDB Length = 635 Score = 52.8 bits (125), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 59/261 (22%), Positives = 107/261 (40%), Gaps = 46/261 (17%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALN-----EKQILEKVNSRFV 246 LG G FG V + +M K +I K + AL E +++++++ ++ Sbjct: 377 LGSGNFGTV----KKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 432 Query: 247 VSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRER 306 V + E ++ LV+ + G L + Y + + ++ G++ L Sbjct: 433 VRMIGICEA-ESWMLVMEMAELGPL--NKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 489 Query: 307 IVYRDLKPENILLDDHGHIRISDLGL--AVHVPEGQTIKGRVGT--VGYMAPEVVKNERY 362 V+RDL N+LL + +ISD GL A+ E G V + APE + ++ Sbjct: 490 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 549 Query: 363 TFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCS 421 + D W+ G L++E + GQ P+ + +K EV ++++ Sbjct: 550 SSKSDVWSFGVLMWEAFSYGQKPY----RGMKGSEVTAMLEK------------------ 587 Query: 422 QLLCKDPAERLGCRGGSAREV 442 ER+GC G RE+ Sbjct: 588 -------GERMGCPAGCPREM 601 >4LRM-A nrPDB Length = 334 Score = 52.8 bits (125), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 54/212 (25%), Positives = 90/212 (42%), Gaps = 17/212 (8%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMY----ACKKLEKKRIKKRKGEAMALNEKQILEKV 241 F++ +VLG G FG V G+ A K+L + K E L+E ++ V Sbjct: 21 FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEI--LDEAYVMASV 78 Query: 242 NSR---FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 ++ V L T + + G L + H G + + +I G Sbjct: 79 DNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIG--SQYLLNWCVQIAKG 136 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA----VHVPEGQTIKGRVGTVGYMAP 354 + L R+V+RDL N+L+ H++I+D GLA E G+V + +MA Sbjct: 137 MNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKV-PIKWMAL 195 Query: 355 EVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 E + + YT D W+ G ++E++ G P+ Sbjct: 196 ESILHRIYTHQSDVWSYGVTVWELMTFGSKPY 227 >4RT7-A nrPDB Length = 415 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 31/99 (31%), Positives = 52/99 (52%), Gaps = 4/99 (4%) Query: 291 YAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA--VHVPEGQTIKGRVGT 348 +A ++ G+E L + V+RDL N+L+ ++I D GLA + ++G Sbjct: 248 FAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARL 307 Query: 349 -VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 V +MAPE + YT D W+ G LL+E+ + G +P+ Sbjct: 308 PVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPY 346 >3Q4U-A nrPDB Length = 301 Score = 52.4 bits (124), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 60/207 (28%), Positives = 84/207 (40%), Gaps = 26/207 (12%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 +GKG +GEV + G+ A K + K E N + + F+ S Sbjct: 16 VGKGRYGEVWRGSWQ--GENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMT 73 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE------ 305 + + L L+ G L ++ R V I GL LH E Sbjct: 74 SRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVL---SIASGLAHLHIEIFGTQG 130 Query: 306 --RIVYRDLKPENILLDDHGHIRISDLGLAV-HVPEGQTI----KGRVGTVGYMAPEVVK 358 I +RDLK +NIL+ +G I+DLGLAV H + RVGT YMAPEV+ Sbjct: 131 KPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLD 190 Query: 359 N-------ERYTFSPDWWALGCLLYEM 378 + Y D WA G +L+E+ Sbjct: 191 ETIQVDCFDSYK-RVDIWAFGLVLWEV 216 >5X18-A nrPDB Length = 295 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 53/224 (23%), Positives = 95/224 (42%), Gaps = 23/224 (10%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMAL-NEKQILEKVNSRFVVSLA 250 +G+G FG + G A K + RK EA L +E + + +N + A Sbjct: 15 IGEGSFGVLFEGTNMINGVPVAIK------FEPRKTEAPQLRDEYKTYKILNGTPNIPYA 68 Query: 251 YAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYR 310 Y + + +++ + G L+ ++ F V A ++ +EDLH ++YR Sbjct: 69 YYFGQEGLHNILVIDLLGPSLE-DLFDWCGRKFSVKTVVQVAVQMITLIEDLHAHDLIYR 127 Query: 311 DLKPENILLD-----DHGHIRISDLGLAV---------HVPEGQTIKGRVGTVGYMAPEV 356 D+KP+N L+ D +I + D G+A H+P + K GT YM+ Sbjct: 128 DIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREK-KSLSGTARYMSINT 186 Query: 357 VKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERL 400 + D ALG + + + G P+Q K +++ E++ Sbjct: 187 HLGREQSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKI 230 >1PY5-A nrPDB Length = 326 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 67/212 (31%), Positives = 92/212 (43%), Gaps = 36/212 (16%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 +GKG FGEV + R G+ A K I + E E +I + V R L + Sbjct: 37 IGKGRFGEVWRGKWR--GEEVAVK------IFSSREERSWFREAEIYQTVMLRHENILGF 88 Query: 252 -AYETKDA-----LCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 A + KD L LV G L ++ + + A GL LH E Sbjct: 89 IAADNKDNGTWTQLWLVSDYHEHGSL---FDYLNRYTVTVEGMIKLALSTASGLAHLHME 145 Query: 306 --------RIVYRDLKPENILLDDHGHIRISDLGLAV-HVPEGQTI----KGRVGTVGYM 352 I +RDLK +NIL+ +G I+DLGLAV H TI RVGT YM Sbjct: 146 IVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYM 205 Query: 353 APEVVK---NERYTFS---PDWWALGCLLYEM 378 APEV+ N ++ S D +A+G + +E+ Sbjct: 206 APEVLDDSINMKHFESFKRADIYAMGLVFWEI 237 >3LMG-A nrPDB Length = 344 Score = 52.0 bits (123), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 52/208 (25%), Positives = 95/208 (45%), Gaps = 12/208 (5%) Query: 186 FRQYRVLGKGGFGEVCACQVRATG---KMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 R+ +VLG G FG V G K+ C K+ + + ++ +A+ + I + Sbjct: 33 LRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDH 92 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHI-YHMGQAGFPEARAVFYAAEICCGLED 301 + V L +L LV + G L H+ H G G P+ + + +I G+ Sbjct: 93 AHIVRLLGLC--PGSSLQLVTQYLPLGSLLDHVRQHRGALG-PQL-LLNWGVQIAKGMYY 148 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVP--EGQTIKGRVGT-VGYMAPEVVK 358 L +V+R+L N+LL ++++D G+A +P + Q + T + +MA E + Sbjct: 149 LEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIH 208 Query: 359 NERYTFSPDWWALGCLLYEMIA-GQSPF 385 +YT D W+ G ++E++ G P+ Sbjct: 209 FGKYTHQSDVWSYGVTVWELMTFGAEPY 236 >6EQI-C nrPDB Length = 433 Score = 52.0 bits (123), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 42/160 (26%), Positives = 69/160 (43%), Gaps = 31/160 (19%) Query: 298 GLEDLHRERIVYRDLKPENILLD-----DHGHIRISDLGL-------AVHVPEGQTIKGR 345 + ++ I +RDLK +NIL+D + I I+D G + +P + + Sbjct: 179 AVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDK 238 Query: 346 VGTVGYMAPEVVKNERYTFS------PDWWALGCLLYEMIAGQSPFQQRKKKI-----KR 394 G MAPE+ + TFS D WA+G + YE+ +PF + K+ K Sbjct: 239 GGNRALMAPEIANAKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDKTMKLLSKSYKE 298 Query: 395 EEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGC 434 E++ L +P R+L S +L + +RL C Sbjct: 299 EDLPELPDTIPF--------IIRNLVSNMLSRSTNKRLDC 330 >5C26-A nrPDB Length = 299 Score = 52.0 bits (123), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 59/261 (22%), Positives = 107/261 (40%), Gaps = 46/261 (17%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALN-----EKQILEKVNSRFV 246 LG G FG V + +M K +I K + AL E +++++++ ++ Sbjct: 35 LGSGNFGTV----KKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 90 Query: 247 VSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRER 306 V + E ++ LV+ + G L + Y + + ++ G++ L Sbjct: 91 VRMIGICEA-ESWMLVMEMAELGPL--NKYLQQNRHVKDKNIIELVHQVSMGMKYLEESN 147 Query: 307 IVYRDLKPENILLDDHGHIRISDLGL--AVHVPEGQTIKGRVGT--VGYMAPEVVKNERY 362 V+RDL N+LL + +ISD GL A+ E G V + APE + ++ Sbjct: 148 FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF 207 Query: 363 TFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCS 421 + D W+ G L++E + GQ P+ + +K EV ++++ Sbjct: 208 SSKSDVWSFGVLMWEAFSYGQKPY----RGMKGSEVTAMLEK------------------ 245 Query: 422 QLLCKDPAERLGCRGGSAREV 442 ER+GC G RE+ Sbjct: 246 -------GERMGCPAGCPREM 259 >4Y12-A nrPDB Length = 375 Score = 51.6 bits (122), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 32/90 (35%), Positives = 47/90 (52%), Gaps = 5/90 (5%) Query: 283 FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI 342 P A A+ Y EI L LH +VY DLKPENI+L + +++ DLG + + Sbjct: 218 LPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRI---NSF 273 Query: 343 KGRVGTVGYMAPEVVKNERYTFSPDWWALG 372 GT G+ APE+V+ T + D + +G Sbjct: 274 GYLYGTPGFQAPEIVRTGP-TVATDIYTVG 302 >5OAT-A nrPDB Length = 411 Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 42/156 (26%), Positives = 70/156 (44%), Gaps = 29/156 (18%) Query: 298 GLEDLHRERIVYRDLKPENILLD----DHGHIRISDLGL-------AVHVPEGQTIKGRV 346 G+ + I +RDLK +N+LLD + + ISD G + +P + Sbjct: 165 GVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKG 224 Query: 347 GTVGYMAPEVVKNERYTFS------PDWWALGCLLYEMIAGQSPF----QQRKKKIKREE 396 G MAPE++ + TFS D WA+G + YE+ +PF + + K + Sbjct: 225 GNTALMAPEIICQKPGTFSVLNYSKADLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKEGD 284 Query: 397 VERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERL 432 + +L EVP ++L + LL ++P +RL Sbjct: 285 LPKLPDEVPT--------VIQALVANLLKRNPNKRL 312 >2PZI-A nrPDB Length = 681 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 33/96 (34%), Positives = 49/96 (51%), Gaps = 5/96 (5%) Query: 283 FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI 342 P A A+ Y EI L LH +VY DLKPENI+L + +++ DLG + + Sbjct: 179 LPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRI---NSF 234 Query: 343 KGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEM 378 GT G+ APE+V+ T + D + +G L + Sbjct: 235 GYLYGTPGFQAPEIVRTGP-TVATDIYTVGRTLAAL 269 >2QLU-A nrPDB Length = 314 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 33/87 (37%), Positives = 50/87 (57%), Gaps = 10/87 (11%) Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAVHV----PEGQTIKGRVGTVGYMAPEVVK 358 H+ I +RD K +N+LL ++D GLAV P G T G+VGT YMAPEV++ Sbjct: 140 HKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDT-HGQVGTRRYMAPEVLE 198 Query: 359 N----ERYTF-SPDWWALGCLLYEMIA 380 +R F D +A+G +L+E+++ Sbjct: 199 GAINFQRDAFLRIDMYAMGLVLWELVS 225 >4I94-A nrPDB Length = 300 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 58/237 (24%), Positives = 99/237 (41%), Gaps = 15/237 (6%) Query: 206 RATGKMYACKKLEKKRIK-KRKGEAMALNEKQILEKV-------NSRFVVSLAYAYETKD 257 RA +Y K ++RI KR + +Q LE+ N R L YE ++ Sbjct: 40 RAPNVVYKGKLENQRRIAVKRFNRKSWPDSRQFLEEAKAVGQLRNHRMANLLGCCYEDEE 99 Query: 258 ALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED-LHRERIVYRDLKPEN 316 L L+ M L H++H A + A I LE + R +Y DL Sbjct: 100 RL-LIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYR 158 Query: 317 ILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLY 376 +L DD + R+S GL + +G++ + + PE ++ R T ++ G LL Sbjct: 159 VLFDDDANPRLSCFGLMKNSRDGKSYS---TNLAFTPPEYLRTGRVTPESVIYSFGTLLL 215 Query: 377 EMIAGQS-PFQQRKKKIKREEVERLVKEVPE-EYSERFSPQARSLCSQLLCKDPAER 431 ++++G+ P I+ ++ L+ E ++S + L S+ L +P ER Sbjct: 216 DLLSGKHIPPSHALDLIRDRNIQMLMDSGLEGQFSSDDGTELIRLASRCLQYEPRER 272 >2CMW-A nrPDB Length = 310 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 35/132 (26%), Positives = 58/132 (43%), Gaps = 15/132 (11%) Query: 283 FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGH-----IRISDLGLA---- 333 F + A ++ +E +H + ++YRD+KPEN L+ G+ I I D GLA Sbjct: 94 FTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYI 153 Query: 334 -----VHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQR 388 H+P + K GT YM+ + + D ALG + + G P+Q Sbjct: 154 DPETKKHIPYREH-KSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGL 212 Query: 389 KKKIKREEVERL 400 K +E +++ Sbjct: 213 KADTLKERYQKI 224 >5VDK-A nrPDB Length = 297 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 68/273 (24%), Positives = 106/273 (38%), Gaps = 37/273 (13%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR- 244 F + +G G FG V C R G +YA K+ K + E AL+E + Sbjct: 17 FLEVEKIGVGEFGTVYKCIKRLDGCVYAIKR-SMKTFTELSNENSALHEVYAHAVLGHHP 75 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG--FPEARAVFYAAEICCGLEDL 302 VV ++ D + + NGG L+ I ++G F E + +I GL + Sbjct: 76 HVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYI 135 Query: 303 HRERIVYRDLKPENILL------DDHGHI-----------------RISDLGLAVHVPEG 339 H +V+ D+KP NI + + G I +I DLG A + Sbjct: 136 HNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSI--- 192 Query: 340 QTIKGRVGTVGYMAPEVVKNE-RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVE 398 K G ++A E+++ + R+ D +ALG L + AG Sbjct: 193 NKPKVEEGDSRFLANEILQEDYRHLPKADIFALG-LTIAVAAGAESLPTNGAAWHHIRKG 251 Query: 399 RLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 +VP+E SE FS SL ++ D +R Sbjct: 252 NF-PDVPQELSESFS----SLLKNMIQPDAEQR 279 >6J6I-B nrPDB Length = 351 Score = 48.5 bits (114), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 25/79 (31%), Positives = 45/79 (56%), Gaps = 3/79 (3%) Query: 307 IVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT---IKGRVGTVGYMAPEVVKNERYT 363 I++RD+KP ++ LD + ++SDL ++ +PEG++ + +GT GY+ P K T Sbjct: 187 IIHRDVKPMHVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDPLYHKTCFVT 246 Query: 364 FSPDWWALGCLLYEMIAGQ 382 D ++ G L +I G+ Sbjct: 247 EYTDVYSFGICLLVIITGK 265 >5KMM-A nrPDB Length = 329 Score = 48.5 bits (114), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 52/219 (23%), Positives = 92/219 (42%), Gaps = 27/219 (12%) Query: 192 LGKGGFGEV----CACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVV 247 LG+G FG+V C + KM K K+ + + + E ++L + + +V Sbjct: 43 LGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQ--REAELLTMLQHQHIV 100 Query: 248 SLAYAYETKDALCLVLTLMNGGDL-KFHIYHM--------------GQAGFPEARAVFYA 292 L +V M GDL +F H G G + AV A Sbjct: 101 RFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAV--A 158 Query: 293 AEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA--VHVPEGQTIKGRVGT-V 349 +++ G+ L V+RDL N L+ ++I D G++ ++ + + GR + Sbjct: 159 SQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPI 218 Query: 350 GYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQ 387 +M PE + ++T D W+ G +L+E+ G+ P+ Q Sbjct: 219 RWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQ 257 >3EB0-A nrPDB Length = 383 Score = 48.1 bits (113), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 51/231 (22%), Positives = 93/231 (40%), Gaps = 34/231 (14%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKK-LEKKRIKKRKGEAM-ALNEKQILEKVNSRFVV 247 + LG G FG VC +GK +A KK L+ R K R+ + M L+ I++ V+ + Sbjct: 13 KTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKNRELDIMKVLDHVNIIKLVDYFYTT 72 Query: 248 -----------------------------SLAYAYETKDALCLVLTLMNGGDLK-FHIYH 277 S+ L +++ + K + Sbjct: 73 GDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPDTLHKVLKSFI 132 Query: 278 MGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGH-IRISDLGLAVHV 336 P Y ++ + +H I +RD+KP+N+L++ + +++ D G A + Sbjct: 133 RSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLKLCDFGSAKKL 192 Query: 337 PEGQTIKGRVGTVGYMAPEVVKN-ERYTFSPDWWALGCLLYEMIAGQSPFQ 386 + + + Y APE++ YT S D W++GC+ E+I G+ F Sbjct: 193 IPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGKPLFS 243 >2Y4I-B nrPDB Length = 319 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 53/213 (24%), Positives = 99/213 (46%), Gaps = 25/213 (11%) Query: 191 VLGKGGFGEVCACQVRA--TGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVS 248 ++GKG FG+V + ++ ++ + ++K K E MA + + VV Sbjct: 40 LIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTR------HENVVL 93 Query: 249 LAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIV 308 A + L ++ +L G L + + + + A EI G+ LH + I+ Sbjct: 94 FMGACMSPPHLAIITSLCKGRTL-YSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGIL 152 Query: 309 YRDLKPENILLDDHGHIRISDLGL----AVHVPEGQTIKGRV--GTVGYMAPEVVKN--- 359 ++DLK +N+ D+ G + I+D GL V + K R+ G + ++APE+++ Sbjct: 153 HKDLKSKNVFYDN-GKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSP 211 Query: 360 ----ERYTFS--PDWWALGCLLYEMIAGQSPFQ 386 ++ FS D +ALG + YE+ A + PF+ Sbjct: 212 DTEEDKLPFSKHSDVFALGTIWYELHAREWPFK 244 >5VC6-A nrPDB Length = 289 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 71/277 (25%), Positives = 111/277 (40%), Gaps = 49/277 (17%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR- 244 F + +G G FG V C R G +YA K + +K A +++E+ L +V + Sbjct: 13 FHELEKIGSGEFGSVFKCVKRLDGCIYAIK-------RSKKPLAGSVDEQNALREVYAHA 65 Query: 245 ------FVVSLAYAYETKDALCLVLTLMNGGDLKFHI---YHMGQAGFPEARAVFYAAEI 295 VV A+ D + + NGG L I Y + + F EA ++ Sbjct: 66 VLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRI-MSYFKEAELKDLLLQV 124 Query: 296 CCGLEDLHRERIVYRDLKPENILL---------------DDHGH----IRISDLGLAVHV 336 GL +H +V+ D+KP NI + DD +I DLG HV Sbjct: 125 GRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLG---HV 181 Query: 337 PEGQTIKGRVGTVGYMAPEVVKNERYTFSP--DWWALGCLLYEMIAGQSPFQQRKKKIKR 394 + + G ++A EV++ E YT P D +AL L AG P + + Sbjct: 182 TRISSPQVEEGDSRFLANEVLQ-ENYTHLPKADIFAL-ALTVVCAAGAEPLPRNGDQWHE 239 Query: 395 EEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 RL + +P+ S+ F+ L ++ DP R Sbjct: 240 IRQGRLPR-IPQVLSQEFT----ELLKVMIHPDPERR 271 >5J0A-A nrPDB Length = 300 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 46/166 (27%), Positives = 80/166 (48%), Gaps = 15/166 (9%) Query: 232 LNEKQILEKVNSRFVVSLAYAYETKD-ALCLVLTLMNGG-----DLKFHIYHMGQAGFPE 285 ++E +IL+ ++ +V E D +LCL + GG DL Y Q FP Sbjct: 62 MDEAKILKSLHHPNIVGYRAFTEANDGSLCLAMEY--GGEKSLNDLIEERYKASQDPFPA 119 Query: 286 ARAVFYAAEICCGLEDLHRE-RIVYRDLKPENILLD-DHGHIRISDLGLAVHVPEGQTIK 343 A + A + GL+ LH+E ++++ D+K N+++ D I+I D+G+++ + E + Sbjct: 120 AIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVT 179 Query: 344 G----RVGTVGYMAPEVV-KNERYTFSPDWWALGCLLYEMIAGQSP 384 +GT + E V +N T D +A G L+EM+ P Sbjct: 180 DPEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIP 225 >2C47-A nrPDB Length = 313 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 58/232 (25%), Positives = 94/232 (40%), Gaps = 25/232 (10%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLE--KKRIKKRKGEAMALNEKQILEKVN 242 FR + +G G FGE+ + T + Y KLE K R + E + E V Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNE-YVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVP 63 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 + Y +VL L+ G L+ ++ + F + A ++ +E + Sbjct: 64 QVYYFGPCGKYN-----AMVLELL-GPSLE-DLFDLCDRTFTLKTVLMIAIQLITRMEYV 116 Query: 303 HRERIVYRDLKPENILLDDHGH-----IRISDLGLA---------VHVPEGQTIKGRVGT 348 H + ++YRD+KPEN L+ G I I D GLA H+P + K GT Sbjct: 117 HTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREH-KSLTGT 175 Query: 349 VGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERL 400 YM+ + + D ALG + + G P+Q K +E +++ Sbjct: 176 ARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKI 227 >4NFN-A nrPDB Length = 309 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 55/245 (22%), Positives = 100/245 (40%), Gaps = 22/245 (8%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 V K+ ++ + +G GGFGE+ T + A K ++ K+ + E +L+K Sbjct: 18 VVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQ-----VLKMEVAVLKK 72 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 + + V + V+ + G +L + F + + +I +E Sbjct: 73 LQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIE 132 Query: 301 DLHRERIVYRDLKPENILL----DDHGHIRISDLGLAVHVPEG-------QTIKGRVGTV 349 +H ++RD+KP N + + + D GLA + + G GTV Sbjct: 133 AIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTV 192 Query: 350 GYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKK----IKREEVER--LVKE 403 Y + KN D W+L +L E GQ P+++ K K + +E+ E L+K Sbjct: 193 RYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKH 252 Query: 404 VPEEY 408 +P E+ Sbjct: 253 MPSEF 257 >4BTK-A nrPDB Length = 337 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 55/245 (22%), Positives = 100/245 (40%), Gaps = 22/245 (8%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 V K+ ++ + +G GGFGE+ T + A K ++ K+ + E +L+K Sbjct: 53 VVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQ-----VLKMEVAVLKK 107 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 + + V + V+ + G +L + F + + +I +E Sbjct: 108 LQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIE 167 Query: 301 DLHRERIVYRDLKPENILL----DDHGHIRISDLGLAVHVPEG-------QTIKGRVGTV 349 +H ++RD+KP N + + + D GLA + + G GTV Sbjct: 168 AIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTV 227 Query: 350 GYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKK----IKREEVER--LVKE 403 Y + KN D W+L +L E GQ P+++ K K + +E+ E L+K Sbjct: 228 RYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKH 287 Query: 404 VPEEY 408 +P E+ Sbjct: 288 MPSEF 292 >3MDY-A nrPDB Length = 337 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 59/213 (27%), Positives = 92/213 (43%), Gaps = 38/213 (17%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR------F 245 +GKG +GEV + R G+ A K EA E +I + V R F Sbjct: 45 IGKGRYGEVWMGKWR--GEKVAVKVFFTTE------EASWFRETEIYQTVLMRHENILGF 96 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVF-YAAEICCGLEDLHR 304 + + + L L+ G L Y ++ +A+++ A GL LH Sbjct: 97 IAADIKGTGSWTQLYLITDYHENGSL----YDYLKSTTLDAKSMLKLAYSSVSGLCHLHT 152 Query: 305 E--------RIVYRDLKPENILLDDHGHIRISDLGLAVH-VPEGQTI----KGRVGTVGY 351 E I +RDLK +NIL+ +G I+DLGLAV + + + RVGT Y Sbjct: 153 EIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRY 212 Query: 352 MAPEVV-----KNERYTF-SPDWWALGCLLYEM 378 M PEV+ +N ++ D ++ G +L+E+ Sbjct: 213 MPPEVLDESLNRNHFQSYIMADMYSFGLILWEV 245 >2CHL-A nrPDB Length = 351 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 34/132 (25%), Positives = 57/132 (43%), Gaps = 15/132 (11%) Query: 283 FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGH-----IRISDLGLA---- 333 F + A ++ +E +H + ++YRD+KPEN L+ G+ I I D LA Sbjct: 123 FSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYI 182 Query: 334 -----VHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQR 388 H+P + K GT YM+ + + D ALG + + G P+Q Sbjct: 183 DPETKKHIPYREH-KSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGL 241 Query: 389 KKKIKREEVERL 400 K +E +++ Sbjct: 242 KADTLKERYQKI 253 >5CLR-A nrPDB Length = 451 Score = 45.4 bits (106), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 53/191 (27%), Positives = 86/191 (45%), Gaps = 21/191 (10%) Query: 210 KMYACKKLEKKRIKKRKGEAMAL----NEKQILEKVNSRFVVSLAYAYETKDALCLVLTL 265 K+YA + +K K +A +L NEK L K+ R V + + E ++ T Sbjct: 97 KVYALDDGKTYFLKSVKIDAESLTEFTNEKDTLSKLG-RLVGT--FFNEQTQVHYILTTF 153 Query: 266 MNGGDLKFHI----YHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDD 321 + G DL + ++ F E + + +C ++ H +++RDLKP NI+LD Sbjct: 154 IKGIDLSRYKNALPLNVNLKHFWEVLGIMIS--VCHQVKQFHELGLIHRDLKPGNIMLDA 211 Query: 322 HGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERY-TFS--PDWWALGCLLYEM 378 + D G + E + GT Y+APE+ E + FS D +AL L E+ Sbjct: 212 DMQCHLVDFGSSSSDKEPK--PASWGTASYLAPELNAQEDFIAFSQVSDLFALAYSLDEL 269 Query: 379 IAGQSPFQQRK 389 +PF+Q K Sbjct: 270 F---NPFRQVK 277 >3G2F-A nrPDB Length = 336 Score = 45.1 bits (105), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 28/95 (29%), Positives = 47/95 (49%), Gaps = 16/95 (16%) Query: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIK---------GRVGTVGY 351 D ++ I +RDL N+L+ + G ISD GL++ + + ++ VGT+ Y Sbjct: 135 DHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRY 194 Query: 352 MAPEVVKN-------ERYTFSPDWWALGCLLYEMI 379 MAPEV++ E D +ALG + +E+ Sbjct: 195 MAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIF 229 >5DMZ-A nrPDB Length = 365 Score = 45.1 bits (105), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 24/112 (21%), Positives = 53/112 (47%), Gaps = 14/112 (12%) Query: 284 PEARAVFYAAEICCGLEDLHRERIVYRDLKPENILL-----------DDHGHIRISDLGL 332 P+ + +A + +E +H I++ D+KP+N +L D + + DLG Sbjct: 170 PQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQ 229 Query: 333 AVHV---PEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAG 381 ++ + P+G + T G+ E++ N+ + + D++ + +Y M+ G Sbjct: 230 SIDMKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFG 281 >5E8V-A nrPDB Length = 316 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 55/219 (25%), Positives = 96/219 (43%), Gaps = 37/219 (16%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMAL--NEKQILEKVNSRF--V 246 ++GKG F EV +A K ++ E +K E A EK I +N + + Sbjct: 16 LVGKGRFAEV----YKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENI 71 Query: 247 VSLAYAYETKDAL----CLVLTLMNGGDLKFHIY-HMGQAGFPEARAVFYAAEICCGLED 301 + A E K L L+ G+L+ ++ H+ + + R + + + G+ Sbjct: 72 LQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHV--ISWEDLRKL--GSSLARGIAH 127 Query: 302 LHRER---------IVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI-----KGRVG 347 LH + IV+RDLK NIL+ + + D GL++ + ++ G+VG Sbjct: 128 LHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVG 187 Query: 348 TVGYMAPEV------VKNERYTFSPDWWALGCLLYEMIA 380 T YMAPEV ++N D +++ +L+EM + Sbjct: 188 TARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTS 226 >4TN6-A nrPDB Length = 318 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 56/229 (24%), Positives = 98/229 (42%), Gaps = 19/229 (8%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 N +R R +G G FG++ A G+ A K LE + K + + K + V Sbjct: 7 NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIK-LECVKTKHPQLHIESKIYKMMQGGVG- 64 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 + ++ + D +V+ L+ G L+ +++ F + A ++ +E +H Sbjct: 65 --IPTIRWCGAEGDYNVMVMELL-GPSLE-DLFNFCSRKFSLKTVLLLADQMISRIEYIH 120 Query: 304 RERIVYRDLKPENIL--LDDHGH-IRISDLGLAV---------HVPEGQTIKGRVGTVGY 351 + ++RD+KP+N L L G+ + I D GLA H+P + K GT Y Sbjct: 121 SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYREN-KNLTGTARY 179 Query: 352 MAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERL 400 + + D +LG +L G P+Q K KR++ ER+ Sbjct: 180 ASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERI 228 >1CSN-A nrPDB Length = 298 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 30/123 (24%), Positives = 54/123 (43%), Gaps = 15/123 (12%) Query: 292 AAEICCGLEDLHRERIVYRDLKPENILL-----DDHGHIRISDLGLAV---------HVP 337 A ++ ++ +H + +VYRD+KP+N L+ + I + D G+ H+P Sbjct: 112 AKQMLARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIP 171 Query: 338 EGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEV 397 + K GT YM+ + D ALG + + G P+Q K +++ Sbjct: 172 YREK-KNLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKY 230 Query: 398 ERL 400 ER+ Sbjct: 231 ERI 233 >4F9B-A nrPDB Length = 361 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 54/246 (21%), Positives = 92/246 (37%), Gaps = 43/246 (17%) Query: 174 KWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYAC--KKLEKKRIKKRKGEAMA 231 K E P N F+ +G+G F V AT ++ +K+ K + Sbjct: 11 KLYEAVPQLSNVFKIEDKIGEGTFSSV----YLATAQLQVGPEEKIALKHLIPTSHPIRI 66 Query: 232 LNEKQILEKVNSR-FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVF 290 E Q L + V+ + Y + D + + + + + + F E R Sbjct: 67 AAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESF---LDILNSLSFQEVRE-- 121 Query: 291 YAAEICCGLEDLHRERIVYRDLKPENILLDDH-GHIRISDLGLA---------------- 333 Y + L+ +H+ IV+RD+KP N L + + D GLA Sbjct: 122 YMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQS 181 Query: 334 -------------VHVPEGQTIKGRVGTVGYMAPEVV-KNERYTFSPDWWALGCLLYEMI 379 + + Q + R GT G+ APEV+ K T + D W+ G + ++ Sbjct: 182 EAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLL 241 Query: 380 AGQSPF 385 +G+ PF Sbjct: 242 SGRYPF 247 >4NT4-A nrPDB Length = 312 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 34/132 (25%), Positives = 54/132 (40%), Gaps = 15/132 (11%) Query: 283 FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGH-----IRISDLGLAV--- 334 F + A ++ +E +H ++YRD+KPEN L+ I I D GLA Sbjct: 111 FSLKTVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYI 170 Query: 335 ------HVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQR 388 H+P + K GT YM+ + D ALG + + G P+Q Sbjct: 171 DLDTNRHIPYREH-KSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGL 229 Query: 389 KKKIKREEVERL 400 K +E +++ Sbjct: 230 KADTLKERYQKI 241 >3SV0-A nrPDB Length = 483 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 55/235 (23%), Positives = 97/235 (41%), Gaps = 21/235 (8%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 +P N FR R +G G FGE+ T + A K LE + K L E +I Sbjct: 2 EPRVGNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIK-LENVKTK----HPQLLYESKIY 56 Query: 239 EKV-NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 + + ++ + D LV+ L+ G L+ +++ + A ++ Sbjct: 57 RILQGGTGIPNVRWFGVEGDYNVLVMDLL-GPSLE-DLFNFCSRKLSLKTVLMLADQMIN 114 Query: 298 GLEDLHRERIVYRDLKPENILLD---DHGHIRISDLGLAV---------HVPEGQTIKGR 345 +E +H + ++RD+KP+N L+ + I D GLA H+P + K Sbjct: 115 RVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYREN-KNL 173 Query: 346 VGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERL 400 GT Y + + D +LG +L + G P+Q K K+++ E++ Sbjct: 174 TGTARYASVNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKI 228 >6EWX-A nrPDB Length = 484 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 53/211 (25%), Positives = 82/211 (38%), Gaps = 54/211 (25%) Query: 277 HMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILL----------------- 319 H + E R F ++C GLE L I++RDL EN+LL Sbjct: 201 HRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSV 260 Query: 320 -----------------------DDH-GHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPE 355 + H + IS+ A P G T + + +APE Sbjct: 261 PTTTSRCPSAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQARLAPE 320 Query: 356 VVKNERYTFSPDWWALGCLLYEMIAGQSPF----QQRKKKIKREEVERLVKEVPEEYSER 411 +V +Y D + G L+YE++ +PF Q R++ +RE++ P Sbjct: 321 IVSASQYR-KFDEFQTGILIYELLHQPNPFEVRAQLRERDYRREDLP------PLPTLSL 373 Query: 412 FSPQARSLCSQLLCKDPAERLGCRGGSAREV 442 +SP + L LL DP +R+ R G A+ V Sbjct: 374 YSPGLQQLAHLLLEADPIKRI--RIGEAKRV 402 >5M07-A nrPDB Length = 276 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 61/277 (22%), Positives = 94/277 (33%), Gaps = 60/277 (21%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLE---------KKRIKKRKGEAMA 231 VT + R+LG GEV Q A K L ++R ++ A Sbjct: 27 VTFAGYTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAAR 86 Query: 232 LNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFY 291 L ILE V+ R E L + + ++G D H+ A P + Sbjct: 87 LFHPHILE-VHDR--------GEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAI 137 Query: 292 AAEICCGLEDLHRERIVYRDLKPENILLDDHG----HIRISDLGLAVHVPEGQTIKGRVG 347 + L+ H+ +++RD+ P N++L I ++D G+A Sbjct: 138 VTAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIA-------------S 184 Query: 348 TVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAG--------QSPFQQRKKKIKREEVER 399 Y APE+ D +AL + AG P Q K R ++ R Sbjct: 185 QPSYPAPELSAGADVDGRADQYALALTAIHLFAGAPPVDRSHTGPLQPPKLSAFRPDLAR 244 Query: 400 LVKEVPEEYSERFSPQARSLCSQLLCKDPAERLG-CR 435 L + S+ L PA+R G CR Sbjct: 245 L----------------DGVLSRALATAPADRFGSCR 265 >4JRN-A nrPDB Length = 372 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 26/81 (32%), Positives = 37/81 (45%), Gaps = 6/81 (7%) Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPE--- 355 + ++ + IV+ D+KP N LL G + + D G ++ +GT GY PE Sbjct: 215 VANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGT---YRINNSVGRAIGTPGYEPPERPF 271 Query: 356 VVKNERYTFSPDWWALGCLLY 376 YTF D W LG LY Sbjct: 272 QATGITYTFPTDAWQLGITLY 292 >4XHL-A nrPDB Length = 394 Score = 42.4 bits (98), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 33/153 (21%), Positives = 65/153 (42%), Gaps = 20/153 (13%) Query: 283 FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLD---DHGHIRISDLGLAV----- 334 F + A ++ C ++ +H ++RD+KP+N L+ + + D GL+ Sbjct: 100 FSFKTVIMLALQMFCRIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDF 159 Query: 335 ----HVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKK 390 H+P + K GT Y + + D +LG +L G P+Q K Sbjct: 160 NTHRHIPYREN-KSLTGTARYASVNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKA 218 Query: 391 KIKREEVERLVKEVPEEYSERFSPQARSLCSQL 423 K+++ +R+++ ++ + +LCS L Sbjct: 219 TTKKQKYDRIME-------KKLNVSVETLCSGL 244 >4L68-A nrPDB Length = 340 Score = 42.4 bits (98), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 39/138 (28%), Positives = 61/138 (44%), Gaps = 15/138 (10%) Query: 249 LAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIV 308 L Y Y + L +L N G+L + + G AR + + C R I+ Sbjct: 112 LVYKYMSNGTLHSLLD-SNRGELDWSTRF--RIGLGAARGLAWLHHGC-------RPPIL 161 Query: 309 YRDLKPENILLDDHGHIRISDLGLA-VHVP----EGQTIKGRVGTVGYMAPEVVKNERYT 363 ++++ IL+D+ RI D GLA + VP E + G +G GY+APE + Sbjct: 162 HQNICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEYSTTMLAS 221 Query: 364 FSPDWWALGCLLYEMIAG 381 D + LG +L E+ G Sbjct: 222 LKGDVYGLGVVLLELATG 239 >4XHH-A nrPDB Length = 403 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 49/230 (21%), Positives = 97/230 (42%), Gaps = 19/230 (8%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 FR R +G G FG++ +G+ A + LE R + + + + K + V F Sbjct: 9 FRIGRKIGSGSFGDIYHGTNLISGEEVAIR-LESIRSRHPQLDYESRVYKYLSGGVGIPF 67 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 + E +V+ L+ G L+ +++ F + A ++ C ++ +H Sbjct: 68 IRWFGREGEYN---AMVIDLL-GPSLE-DLFNYCHRKFSFKTVIMLALQMICRVQYIHGR 122 Query: 306 RIVYRDLKPENILLD---DHGHIRISDLGLAV---------HVPEGQTIKGRVGTVGYMA 353 ++RD+KP+N L+ + + D GL+ H+P + K GT Y + Sbjct: 123 SFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYREN-KSLTGTARYAS 181 Query: 354 PEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKE 403 + D +LG +L G P+Q K K+++ +R++++ Sbjct: 182 VNTHLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEK 231 >3REP-A nrPDB Length = 271 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 46/185 (24%), Positives = 83/185 (44%), Gaps = 27/185 (14%) Query: 260 CLVLTLMNGGDLKFHIYHMGQA-GFPEARAVFYAAEICCGLEDLHR-ERIVYRD-LKPEN 316 L+ M G L +++ H G +++AV +A ++ G+ LH E ++ R L + Sbjct: 85 TLITHWMPYGSL-YNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRS 143 Query: 317 ILLDDHGHIRIS--DLGLAVHVPEGQTIKGRVGTVGYMAPEVVK------NERYTFSPDW 368 +++D+ RIS D+ + P GR+ ++APE ++ N R S D Sbjct: 144 VMIDEDMTARISMADVKFSFQSP------GRMYAPAWVAPEALQKKPEDTNRR---SADM 194 Query: 369 WALGCLLYEMIAGQSPFQ--QRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCK 426 W+ LL+E++ + PF + + +E L +P SP L + + Sbjct: 195 WSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPG----ISPHVSKLMKICMNE 250 Query: 427 DPAER 431 DPA+R Sbjct: 251 DPAKR 255 >5FQD-C nrPDB Length = 341 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 62/289 (21%), Positives = 118/289 (40%), Gaps = 38/289 (13%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 + ++ R +G G FG++ G+ A K LE ++ + L E ++ + Sbjct: 16 IVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVK-LESQKAR----HPQLLYESKLYKI 70 Query: 241 VNSRFVV-SLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 + + + + + KD LV+ L+ G L+ +++ F + A ++ + Sbjct: 71 LQGGVGIPHIRWYGQEKDYNVLVMDLL-GPSLE-DLFNFCSRRFTMKTVLMLADQMISRI 128 Query: 300 EDLHRERIVYRDLKPENILLDDHGH---IRISDLGLAV---------HVPEGQTIKGRVG 347 E +H + ++RD+KP+N L+ H + + D GLA H+P + K G Sbjct: 129 EYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYRED-KNLTG 187 Query: 348 TVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEE 407 T Y + + D +LG +L P+Q K K+++ E++ Sbjct: 188 TARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKI------- 240 Query: 408 YSERFSPQARSLCSQLLCKD-PAERLG----CRGGSAREVKEHPLFKKL 451 S + S ++LCK PAE CRG E ++ ++L Sbjct: 241 -----SEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQL 284 >2X7G-A nrPDB Length = 389 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 58/261 (22%), Positives = 95/261 (36%), Gaps = 67/261 (25%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV---- 241 + R LG G F V C GK + K+ K + AL+E ++L+ V Sbjct: 33 YHVIRKLGWGHFSTVWLCW-DMQGKRFVAMKVVKS---AQHYTETALDEIKLLKCVRESD 88 Query: 242 ----NSRFVVSLAYAYETKDA----LCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAA 293 N VV L ++ +C+V ++ LK+ I G P Sbjct: 89 PSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKW-IIKSNYQGLPVRCVKSIIR 147 Query: 294 EICCGLEDLHRE-RIVYRDLKPENILL--------------------------------- 319 ++ GL+ LH + +I++ D+KPENIL+ Sbjct: 148 QVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTA 207 Query: 320 --------------DDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFS 365 D ++I+DLG A V + T + T Y + EV+ Y+ Sbjct: 208 PAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFT--EDIQTRQYRSIEVLIGAGYSTP 265 Query: 366 PDWWALGCLLYEMIAGQSPFQ 386 D W+ C+ +E+ G F+ Sbjct: 266 ADIWSTACMAFELATGDYLFE 286 >4WUA-A nrPDB Length = 401 Score = 37.4 bits (85), Expect = 0.016, Method: Compositional matrix adjust. Identities = 39/147 (26%), Positives = 63/147 (42%), Gaps = 19/147 (12%) Query: 188 QYRVLGKGGFGEVCACQVR--ATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV---- 241 +Y V+ K G+G + GK + K+ K AL+E ++L+ V Sbjct: 42 RYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKS---AEHYTETALDEIRLLKSVRNSD 98 Query: 242 ----NSRFVVSLAYAYETKDA----LCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAA 293 N VV L ++ +C+V ++ LK+ I G P Sbjct: 99 PNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKW-IIKSNYQGLPLPCVKKIIQ 157 Query: 294 EICCGLEDLHRE-RIVYRDLKPENILL 319 ++ GL+ LH + RI++ D+KPENILL Sbjct: 158 QVLQGLDYLHTKCRIIHTDIKPENILL 184 >4M69-B nrPDB Length = 283 Score = 37.4 bits (85), Expect = 0.020, Method: Compositional matrix adjust. Identities = 27/115 (23%), Positives = 52/115 (45%), Gaps = 7/115 (6%) Query: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA-----VHVPEGQTIKGRVGTVGYM 352 GL LH ++R++ + L+ ++++ L+ + T R + Y+ Sbjct: 124 GLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYV 183 Query: 353 APEVVKNE--RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVP 405 +PE +KN Y + ++ G +L+E+ G+ PF+ K RE V K+ P Sbjct: 184 SPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEP 238 >6BHC-A nrPDB Length = 438 Score = 37.0 bits (84), Expect = 0.023, Method: Compositional matrix adjust. Identities = 37/161 (22%), Positives = 70/161 (43%), Gaps = 31/161 (19%) Query: 296 CCGLEDLHRERIVYRDLKPENILLDDH---------------------GHIRISDLGLA- 333 C GLE L + + DL+ EN+LL + + +S+ A Sbjct: 188 CSGLEHLKPYHVTHCDLRLENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAK 247 Query: 334 --VHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKK 391 H+ + + ++ + +APE++ +Y D + G L+YEM+ +PF + + Sbjct: 248 QKSHLVDPEILRDQ----SRLAPEIITATQYK-KCDEFQTGILIYEMLHLPNPFDENPEL 302 Query: 392 IKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERL 432 +RE + +P + +S + L S LL +P+ER+ Sbjct: 303 KEREYTRADLPRIP--FRSPYSRGLQQLASCLLNPNPSERI 341 >4BTF-A nrPDB Length = 469 Score = 37.0 bits (84), Expect = 0.025, Method: Compositional matrix adjust. Identities = 27/115 (23%), Positives = 52/115 (45%), Gaps = 7/115 (6%) Query: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA-----VHVPEGQTIKGRVGTVGYM 352 GL LH ++R++ + L+ ++++ L+ + T R + Y+ Sbjct: 310 GLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYV 369 Query: 353 APEVVKNE--RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVP 405 +PE +KN Y + ++ G +L+E+ G+ PF+ K RE V K+ P Sbjct: 370 SPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEP 424 >4CYJ-A nrPDB Length = 438 Score = 36.6 bits (83), Expect = 0.029, Method: Compositional matrix adjust. Identities = 36/144 (25%), Positives = 58/144 (40%), Gaps = 21/144 (14%) Query: 200 VCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETK--- 256 V Q G+ YA ++LE R+ K LN + +K+ + +V++ + T+ Sbjct: 71 VYKAQNSRNGRHYALRRLEGYRLTNEKA---ILNVMKDWKKIKNASIVTIHEVFTTREFG 127 Query: 257 --------DALCLVLTLMNGGDLKFHIYHMGQ----AGFPEARAVFYAAEICCGLEDLHR 304 D L TL + F H + PE Y +I L+ +H Sbjct: 128 DSSLIFAYDFHPLSKTLQ---EHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTIHS 184 Query: 305 ERIVYRDLKPENILLDDHGHIRIS 328 R+ R L+P I+L D IR+S Sbjct: 185 NRLAARCLEPSKIILTDINRIRLS 208 >3BYV-A nrPDB Length = 377 Score = 36.6 bits (83), Expect = 0.029, Method: Compositional matrix adjust. Identities = 32/119 (26%), Positives = 52/119 (43%), Gaps = 14/119 (11%) Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV-- 356 L LH +V+ L+P +I+LD G + ++ G V +G + V G+ PE+ Sbjct: 219 LASLHHYGLVHTYLRPVDIVLDQRGGVFLT--GFEHLVRDGARVVSSVSR-GFEPPELEA 275 Query: 357 ----VKNER-----YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPE 406 + R TFS D WALG ++Y + P + E + R K +P+ Sbjct: 276 RRATISYHRDRRTLMTFSFDAWALGLVIYWIWCADLPITKDAALGGSEWIFRSCKNIPQ 334 >6M7Z-A nrPDB Length = 319 Score = 35.8 bits (81), Expect = 0.052, Method: Compositional matrix adjust. Identities = 39/185 (21%), Positives = 78/185 (42%), Gaps = 36/185 (19%) Query: 292 AAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGY 351 AA + L+ LH +++R ++ + + G + + GL P G + VG G Sbjct: 150 AANMVAALKSLHNLGLLHRSIELNSFSVLPDGTVVLG--GLDTAAPIGTETRLWVGFFGQ 207 Query: 352 -MAPEVVKN---------ERYTFSPDWWALGCL---LYEMIAGQSPFQQRKKKIKREEVE 398 APE+ +N R+T D ++LG L +++ + + + ++++ +E Sbjct: 208 ETAPEIDRNFLADLALTQGRHTVKSDVYSLGVAFRNLVQLLGNGNLGPEDRGAVRQDHLE 267 Query: 399 RLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGA 458 L K L +++ ++P R + E+ + PLF+ LNF+ + Sbjct: 268 LLDK----------------LSQKMIEEEPGNR-----PTIEEIMKDPLFEGLNFEDIEE 306 Query: 459 GMLEP 463 G P Sbjct: 307 GKARP 311 >5UU1-A nrPDB Length = 324 Score = 35.0 bits (79), Expect = 0.079, Method: Compositional matrix adjust. Identities = 36/155 (23%), Positives = 68/155 (43%), Gaps = 14/155 (9%) Query: 279 GQAG-FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLD--DHGHIRISDLGLAV- 334 GQ G F ++ + + LE +H V+ D+K N+LL + + ++D GL+ Sbjct: 122 GQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYR 181 Query: 335 HVPEGQTI-------KGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQ 387 + P G KG GT+ + + + K + D LG + + G+ P++Q Sbjct: 182 YCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQ 241 Query: 388 RKKKIKREEVER--LVKEVPEEYSERFSPQARSLC 420 K + + L+ E+P+ +++P S C Sbjct: 242 NLKDPVAVQTAKTNLLDELPQSVL-KWAPSGSSCC 275 >5VE6-A nrPDB Length = 492 Score = 35.0 bits (79), Expect = 0.086, Method: Compositional matrix adjust. Identities = 32/116 (27%), Positives = 55/116 (47%), Gaps = 5/116 (4%) Query: 327 ISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQ 386 IS+ A P G + + +APE+V +Y D + G L+YE++ +PF+ Sbjct: 300 ISNFLKAKQKPGGTPNLQQKKSQARLAPEIVSASQYR-KFDEFQTGILIYELLHQPNPFE 358 Query: 387 QRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREV 442 R + +R+ + + +P +SP + L LL DP +R+ R G A+ V Sbjct: 359 VRAQLRERDYRQEDLPPLPA--LSLYSPGLQQLAHLLLEADPIKRI--RIGEAKRV 410 Score = 33.1 bits (74), Expect = 0.32, Method: Compositional matrix adjust. Identities = 17/43 (39%), Positives = 23/43 (53%) Query: 277 HMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILL 319 H + E R F ++C GLE L I++RDL EN+LL Sbjct: 199 HQAEPEAYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 >3DZO-A nrPDB Length = 413 Score = 33.9 bits (76), Expect = 0.18, Method: Compositional matrix adjust. Identities = 29/118 (24%), Positives = 47/118 (39%), Gaps = 13/118 (11%) Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVK 358 L LH +V+ L+P +I+LD G + ++ G V +G + +G G+ PE Sbjct: 224 LASLHHYGLVHTYLRPVDIVLDQRGGVFLT--GFEHLVRDGASAVSPIGR-GFAPPETTA 280 Query: 359 NER----------YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPE 406 TF+ D W LG +Y + P E + R K +P+ Sbjct: 281 ERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCADLPNTDDAALGGSEWIFRSCKNIPQ 338 >4O1O-A nrPDB Length = 717 Score = 33.9 bits (76), Expect = 0.19, Method: Compositional matrix adjust. Identities = 20/65 (30%), Positives = 34/65 (52%), Gaps = 1/65 (1%) Query: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEG-QTIKGRVGTVGYMAPEVVKN 359 +LHR ++DL+P+NIL+D ++D ++ E Q IK + +G + VVK Sbjct: 457 ELHRSGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAEDPQKIKRDLEALGLLVLYVVKK 516 Query: 360 ERYTF 364 +F Sbjct: 517 GDISF 521 >3BL5-A nrPDB Length = 219 Score = 31.6 bits (70), Expect = 1.1, Method: Compositional matrix adjust. Identities = 30/114 (26%), Positives = 43/114 (37%), Gaps = 8/114 (7%) Query: 102 GRQLTQNFLSHTGPDLIPEVPRQLVTN-CTQRLEQGP-CKDLFQELTRLTHEYLSVAPFA 159 GR L FLS R ++T C P C+D F + +T PF Sbjct: 96 GRNLV--FLSFASILAYQIGARHIITGVCETDFSGYPDCRDEFVKSCNVTVNLAMEKPFV 153 Query: 160 DYLDSIYFNRFLQWKWLER----QPVTKNTFRQYRVLGKGGFGEVCACQVRATG 209 + ++ N+ WK + V NT Y + G GE AC +R+ G Sbjct: 154 IHTPLMWLNKAETWKLADELGALDFVKNNTLTCYNGIIADGCGECPACHLRSKG 207 >4IX6-A nrPDB Length = 350 Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 16/43 (37%), Positives = 25/43 (58%), Gaps = 2/43 (4%) Query: 294 EICCGLEDLHRERIVYRDLKPENILL--DDHGHIRISDLGLAV 334 E+ L LH +V+RD+KP N++ D G +++ DLG A Sbjct: 151 ELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAA 193 >5X1R-A nrPDB Length = 302 Score = 31.2 bits (69), Expect = 1.4, Method: Compositional matrix adjust. Identities = 54/279 (19%), Positives = 102/279 (36%), Gaps = 46/279 (16%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKR--------KGEAMA---- 231 N F +G+GGFG V + A K+ + KR +GE Sbjct: 21 NEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQ 80 Query: 232 ------LNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPE 285 + E ++L + + ++ + +E + +G LK ++ E Sbjct: 81 AGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLK-NLQAQQPEKIDE 139 Query: 286 ARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR 345 A + + +H+E ++RD+ +NI + + + D G A + Sbjct: 140 AWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSA---------RKE 190 Query: 346 VGTVG-----YMAPEVVKNERYTFSPD-----W---WALGCLLYEMIAGQSPFQQRKKKI 392 +G + + P E+YT + D W +ALG +L+ +I G P + I Sbjct: 191 IGNLSDETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPPPVSVVRSI 250 Query: 393 KREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 + + + L + P Y SP+ + L P +R Sbjct: 251 E-DSYQPLTERRPAGY----SPELLRTVDRALALKPEDR 284 >4MWI-A nrPDB Length = 294 Score = 30.8 bits (68), Expect = 1.6, Method: Compositional matrix adjust. Identities = 22/91 (24%), Positives = 43/91 (47%), Gaps = 8/91 (8%) Query: 345 RVGTVGYMAPEVVKNERYTFS--PDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERL-- 400 RV + Y++P+ +++ Y + + ++ G +L+E+ G PFQ E++ +L Sbjct: 193 RVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQ----GCNSEKIRKLVA 248 Query: 401 VKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 VK E E + R + + DP+ R Sbjct: 249 VKRQQEPLGEDCPSELREIIDECRAHDPSVR 279 >2W1Z-A nrPDB Length = 368 Score = 30.4 bits (67), Expect = 1.9, Method: Compositional matrix adjust. Identities = 27/110 (24%), Positives = 44/110 (40%), Gaps = 13/110 (11%) Query: 307 IVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER----- 361 +V+ D + NILLD G + ++ G V +G + +G G+ PE Sbjct: 212 LVHADFQVRNILLDQRGGVFLT--GFEHLVRDGASAVSPIGR-GFAPPETTAERMLPYRQ 268 Query: 362 -----YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPE 406 TF D W LG +Y + P + + E + R K +P+ Sbjct: 269 HHPTLMTFPFDTWTLGLAIYWIWCADLPNTEDAELGGIEWIYRRCKNIPQ 318 >4AZV-A nrPDB Length = 569 Score = 30.0 bits (66), Expect = 2.9, Method: Compositional matrix adjust. Identities = 12/41 (29%), Positives = 22/41 (53%) Query: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPE 338 L L ++ + D++P N+++D H R+ D G V P+ Sbjct: 351 SLAALEKQGFWHDDVRPWNVMVDARQHARLIDFGSIVTTPQ 391 >3EZ1-A nrPDB Length = 423 Score = 30.0 bits (66), Expect = 3.0, Method: Compositional matrix adjust. Identities = 38/167 (22%), Positives = 65/167 (38%), Gaps = 25/167 (14%) Query: 266 MNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHI 325 M+G DL+ Y G AG P ARA+F Y D+K EN+L+ ++ + Sbjct: 57 MDGLDLRN--YPGGVAGLPSARALFAG----------------YLDVKAENVLVWNNSSL 98 Query: 326 RISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPF 385 + L L + G ++G G P+++ + + L L +E++ Sbjct: 99 ELQGLVLTFALLHG--VRGSTGPWLSQTPKMIVTVP-GYDRHFLLLQTLGFELLT----V 151 Query: 386 QQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERL 432 + + VERL P F P + + + + A RL Sbjct: 152 DMQSDGPDVDAVERLAGTDPSVKGILFVPTYSNPGGETISLEKARRL 198 >2RSV-A nrPDB Length = 403 Score = 30.0 bits (66), Expect = 3.2, Method: Compositional matrix adjust. Identities = 23/75 (30%), Positives = 35/75 (46%), Gaps = 4/75 (5%) Query: 268 GGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLD--DHGHI 325 G DL+ IY F + + I LE +H V+ D+K N+LL+ + + Sbjct: 142 GSDLQ-KIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV 200 Query: 326 RISDLGLAV-HVPEG 339 + D GLA + PEG Sbjct: 201 YLVDYGLAYRYCPEG 215 >2LAV-A nrPDB Length = 361 Score = 29.6 bits (65), Expect = 3.9, Method: Compositional matrix adjust. Identities = 23/75 (30%), Positives = 35/75 (46%), Gaps = 4/75 (5%) Query: 268 GGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLD--DHGHI 325 G DL+ IY F + + I LE +H V+ D+K N+LL+ + + Sbjct: 135 GSDLQ-KIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQV 193 Query: 326 RISDLGLAV-HVPEG 339 + D GLA + PEG Sbjct: 194 YLVDYGLAYRYCPEG 208 >4AZW-A nrPDB Length = 471 Score = 29.3 bits (64), Expect = 4.7, Method: Compositional matrix adjust. Identities = 12/41 (29%), Positives = 22/41 (53%) Query: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPE 338 L L ++ + D++P N+++D H R+ D G V P+ Sbjct: 351 SLAALEKKGFWHDDVRPWNVMVDARQHARLIDFGSIVTTPQ 391 >4CI6-B nrPDB Length = 643 Score = 29.3 bits (64), Expect = 4.9, Method: Compositional matrix adjust. Identities = 23/68 (33%), Positives = 33/68 (48%), Gaps = 5/68 (7%) Query: 290 FYAAEICCGLEDLHRERIVYRDLKPENILLD-DHGHIRISDLGLAVHVPEGQTIKGRVGT 348 F A + L + IV+ D+KP N++ D G + DLGL H G+ KG T Sbjct: 160 FIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRASGEPVVIDLGL--HSRSGEQPKGF--T 215 Query: 349 VGYMAPEV 356 + APE+ Sbjct: 216 ESFKAPEL 223 >4N8G-A nrPDB Length = 352 Score = 28.9 bits (63), Expect = 6.7, Method: Compositional matrix adjust. Identities = 14/55 (25%), Positives = 23/55 (41%), Gaps = 6/55 (10%) Query: 481 EQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPP 535 E F ++ ++P+ Y+ F PIPW T+ + L DG + P Sbjct: 169 EDFEGLRFRAMDPSQVALYEAFGASGTPIPW------TDTYMALKTNVADGQMNP 217 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3NYO-A nrPDB 878 0.0 4TNB-A nrPDB 746 0.0 4YHJ-A nrPDB 729 0.0 3C51-A nrPDB 620 e-178 3PVW-A nrPDB 517 e-147 5UUU-A nrPDB 506 e-143 2JDO-A nrPDB 357 6e-99 3MV5-A nrPDB 355 4e-98 5KCV-A nrPDB 343 2e-94 4RA4-A nrPDB 340 2e-93 3PFQ-A nrPDB 336 1e-92 4L42-A nrPDB 334 6e-92 2I0E-A nrPDB 334 7e-92 1FOT-A nrPDB 331 6e-91 5F9E-A nrPDB 328 3e-90 3A8W-A nrPDB 328 3e-90 3TXO-A nrPDB 328 6e-90 1VZO-A nrPDB 327 7e-90 5X3F-B nrPDB 326 1e-89 5N23-A nrPDB 326 1e-89 5D9K-A nrPDB 326 2e-89 4WB7-A nrPDB 325 3e-89 4RLP-A nrPDB 324 6e-89 3HDN-A nrPDB 321 7e-88 2Z7Q-A nrPDB 319 2e-87 5JN2-A nrPDB 318 4e-87 3MA6-A nrPDB 314 8e-86 3DXN-A nrPDB 312 2e-85 3HZT-A nrPDB 312 3e-85 5FET-A nrPDB 311 8e-85 4MVF-A nrPDB 309 2e-84 6BDL-A nrPDB 309 3e-84 3TKU-A nrPDB 308 3e-84 3LIJ-A nrPDB 305 3e-83 2JC6-A nrPDB 305 3e-83 4FG9-A nrPDB 305 4e-83 5DYK-A nrPDB 303 1e-82 4YZB-A nrPDB 303 1e-82 4RGJ-A nrPDB 301 5e-82 3DFA-A nrPDB 301 6e-82 3NCG-A nrPDB 300 1e-81 5FG8-A nrPDB 299 2e-81 4AW2-A nrPDB 298 3e-81 5IG1-A nrPDB 298 4e-81 4OTD-A nrPDB 297 1e-80 2BDW-A nrPDB 296 1e-80 4FR4-A nrPDB 296 2e-80 2VN9-A nrPDB 296 2e-80 3KK8-A nrPDB 295 4e-80 5U6Y-A nrPDB 294 4e-80 3Q5I-A nrPDB 294 5e-80 2VZ6-A nrPDB 294 8e-80 2V7O-A nrPDB 293 1e-79 3MN3-A nrPDB 293 2e-79 2JAM-A nrPDB 292 3e-79 5KZ7-A nrPDB 292 3e-79 4REW-A nrPDB 291 4e-79 4CRS-A nrPDB 291 4e-79 2QNJ-A nrPDB 291 5e-79 3BHH-A nrPDB 291 5e-79 5ES1-A nrPDB 291 7e-79 4RED-A nrPDB 290 1e-78 4CFF-A nrPDB 290 1e-78 2VD5-A nrPDB 289 1e-78 4CFH-A nrPDB 289 2e-78 3H4J-B nrPDB 289 2e-78 2J90-A nrPDB 289 3e-78 6E9W-A nrPDB 288 4e-78 6ED6-A nrPDB 288 4e-78 3SOA-A nrPDB 288 5e-78 4D28-A nrPDB 287 7e-78 5EZV-A nrPDB 287 8e-78 2YZA-A nrPDB 287 1e-77 5YKS-A nrPDB 286 2e-77 3ORZ-A nrPDB 286 3e-77 5LOH-A nrPDB 284 5e-77 3GUB-A nrPDB 284 5e-77 3D2K-A nrPDB 283 1e-76 4UZD-A nrPDB 282 2e-76 3TAC-A nrPDB 282 3e-76 2YAB-A nrPDB 281 4e-76 2YCR-A nrPDB 281 5e-76 2W4O-A nrPDB 281 6e-76 4CZT-A nrPDB 281 7e-76 2BPM-A nrPDB 280 9e-76 1ZWS-A nrPDB 280 1e-75 2A27-A nrPDB 279 2e-75 3COM-A nrPDB 279 2e-75 2Y7J-A nrPDB 279 2e-75 5XZW-A nrPDB 278 4e-75 1PHK-A nrPDB 278 4e-75 3I6U-A nrPDB 278 5e-75 3F3Z-A nrPDB 278 5e-75 4C0T-A nrPDB 278 7e-75 4JXF-A nrPDB 277 9e-75 5JZN-A nrPDB 274 8e-74 4LG4-A nrPDB 274 1e-73 1KOB-A nrPDB 273 2e-73 5WAX-A nrPDB 273 2e-73 2HAK-A nrPDB 272 3e-73 5J5T-A nrPDB 271 5e-73 6BXI-A nrPDB 271 6e-73 4PDS-A nrPDB 271 6e-73 2X4F-A nrPDB 271 8e-73 3NIZ-A nrPDB 270 1e-72 3UTO-A nrPDB 269 2e-72 6AO5-A nrPDB 269 3e-72 6FD3-A nrPDB 269 3e-72 6C9D-A nrPDB 269 3e-72 4NIF-A nrPDB 268 5e-72 1KOA-A nrPDB 267 1e-71 2F57-A nrPDB 266 1e-71 2UV2-A nrPDB 266 2e-71 4JG6-A nrPDB 266 2e-71 6GU6-A nrPDB 266 2e-71 4CQG-A nrPDB 266 2e-71 4B8L-A nrPDB 265 3e-71 6FDY-U nrPDB 265 3e-71 4YNZ-A nrPDB 264 6e-71 4D2V-A nrPDB 264 6e-71 3IS5-A nrPDB 264 8e-71 3DB8-A nrPDB 264 9e-71 4QMW-A nrPDB 263 2e-70 3ZUT-A nrPDB 263 2e-70 4CSV-A nrPDB 262 2e-70 3UC3-A nrPDB 262 2e-70 4B6L-A nrPDB 261 7e-70 3DAK-A nrPDB 261 7e-70 3Q53-A nrPDB 260 1e-69 3UDB-A nrPDB 260 1e-69 6CMJ-A nrPDB 259 2e-69 4I6B-A nrPDB 259 2e-69 3FXW-A nrPDB 259 3e-69 4KS7-A nrPDB 259 3e-69 4AF3-A nrPDB 258 4e-69 1CM8-A nrPDB 258 5e-69 2XIK-A nrPDB 258 6e-69 6HXF-B nrPDB 257 6e-69 4KRC-A nrPDB 257 7e-69 4FZF-B nrPDB 257 9e-69 2WQN-A nrPDB 257 1e-68 3LM0-A nrPDB 256 2e-68 3KN6-A nrPDB 256 3e-68 2Q0N-A nrPDB 255 5e-68 5D7A-A nrPDB 254 6e-68 4JDH-A nrPDB 254 7e-68 4XBR-A nrPDB 254 8e-68 4FIE-A nrPDB 254 1e-67 4APC-A nrPDB 254 1e-67 4J52-A nrPDB 253 1e-67 4EWQ-A nrPDB 253 1e-67 2OU7-A nrPDB 253 1e-67 5YV8-A nrPDB 252 2e-67 4AGU-A nrPDB 252 3e-67 5DBX-A nrPDB 252 4e-67 1NY3-A nrPDB 252 4e-67 2OZA-A nrPDB 251 5e-67 1G3N-A nrPDB 251 6e-67 3KA0-A nrPDB 251 7e-67 1V0B-A nrPDB 251 9e-67 3HKO-A nrPDB 249 2e-66 4BBM-A nrPDB 248 5e-66 4WNO-A nrPDB 248 5e-66 5AWM-A nrPDB 248 6e-66 2F9G-A nrPDB 247 7e-66 2XYN-A nrPDB 247 7e-66 2HW6-A nrPDB 247 1e-65 4AU8-A nrPDB 246 1e-65 4BGQ-A nrPDB 246 1e-65 4MYG-A nrPDB 246 2e-65 6DTL-A nrPDB 246 3e-65 3OHT-A nrPDB 246 3e-65 6QAU-A nrPDB 246 3e-65 1JNK-A nrPDB 245 3e-65 2XS0-A nrPDB 245 4e-65 3E7O-A nrPDB 245 4e-65 4XEY-B nrPDB 244 1e-64 3FI2-A nrPDB 244 1e-64 4OLI-A nrPDB 243 1e-64 6NPU-A nrPDB 243 2e-64 4QNY-A nrPDB 243 2e-64 2FO0-A nrPDB 242 3e-64 4XLV-A nrPDB 242 3e-64 5EFQ-A nrPDB 241 4e-64 4NST-A nrPDB 241 6e-64 3PPZ-A nrPDB 241 8e-64 3BGP-A nrPDB 240 1e-63 1TKI-A nrPDB 239 2e-63 3GC9-A nrPDB 239 2e-63 5TUR-A nrPDB 239 4e-63 1U5R-A nrPDB 238 4e-63 2GCD-A nrPDB 237 9e-63 6CKI-A nrPDB 237 1e-62 3ZDU-A nrPDB 237 1e-62 4AN9-A nrPDB 236 2e-62 5G6V-A nrPDB 236 2e-62 2H8H-A nrPDB 236 2e-62 6F3F-A nrPDB 236 3e-62 4EBW-A nrPDB 235 4e-62 5Z33-A nrPDB 235 4e-62 4U41-A nrPDB 234 8e-62 6E2O-A nrPDB 234 1e-61 1UA2-A nrPDB 234 1e-61 5H2U-A nrPDB 232 2e-61 6CQF-A nrPDB 232 3e-61 3OZ6-A nrPDB 232 4e-61 2DQ7-X nrPDB 232 4e-61 5SYS-A nrPDB 231 7e-61 3MIA-A nrPDB 231 7e-61 2OGV-A nrPDB 231 8e-61 6CCF-A nrPDB 231 9e-61 1JPA-A nrPDB 230 1e-60 3BEA-A nrPDB 230 1e-60 3KRL-A nrPDB 230 1e-60 4RC3-A nrPDB 230 1e-60 4IC8-A nrPDB 230 1e-60 4ZSG-A nrPDB 230 2e-60 2W96-B nrPDB 229 2e-60 5AIR-A nrPDB 229 2e-60 3GC0-A nrPDB 229 3e-60 3V5Q-A nrPDB 229 3e-60 5NGU-A nrPDB 229 4e-60 4GS6-A nrPDB 228 5e-60 5VO2-A nrPDB 228 5e-60 3TT0-A nrPDB 228 6e-60 4QTB-A nrPDB 228 6e-60 2J0K-A nrPDB 227 8e-60 2PL0-A nrPDB 227 9e-60 5X02-A nrPDB 227 1e-59 4AT3-A nrPDB 226 2e-59 4R7H-A nrPDB 226 2e-59 2BRG-A nrPDB 226 2e-59 3ALO-A nrPDB 225 4e-59 5MJB-A nrPDB 225 5e-59 4E93-A nrPDB 225 5e-59 2XNP-A nrPDB 225 5e-59 4O2Z-A nrPDB 224 1e-58 3DKO-A nrPDB 224 1e-58 4P5Q-A nrPDB 224 1e-58 1K9A-A nrPDB 223 1e-58 6GQK-A nrPDB 223 1e-58 3A4O-X nrPDB 223 1e-58 5GRN-A nrPDB 223 2e-58 4E7W-A nrPDB 223 2e-58 5Y86-A nrPDB 222 2e-58 2Y6O-A nrPDB 222 2e-58 5KKR-C nrPDB 222 4e-58 2R2P-A nrPDB 222 5e-58 1BYG-A nrPDB 222 5e-58 6FEX-A nrPDB 221 6e-58 3I81-A nrPDB 221 6e-58 4H1J-A nrPDB 221 6e-58 5L6P-A nrPDB 221 6e-58 4EQM-A nrPDB 221 7e-58 3EQC-A nrPDB 221 8e-58 5X5O-A nrPDB 221 1e-57 3GQL-A nrPDB 221 1e-57 2WTK-C nrPDB 220 1e-57 3QUP-A nrPDB 220 1e-57 4UY9-A nrPDB 220 1e-57 3VN9-A nrPDB 220 1e-57 3FME-A nrPDB 219 2e-57 6BSD-A nrPDB 219 2e-57 3PG1-A nrPDB 219 2e-57 4UYA-A nrPDB 219 3e-57 3DTC-A nrPDB 219 3e-57 1LUF-A nrPDB 219 3e-57 3M42-A nrPDB 219 4e-57 2VWV-A nrPDB 218 4e-57 5A46-A nrPDB 218 4e-57 5B2L-A nrPDB 218 5e-57 2HK5-A nrPDB 218 5e-57 5AMN-A nrPDB 218 6e-57 3OMV-A nrPDB 218 6e-57 5KMM-A nrPDB 217 8e-57 6DBM-A nrPDB 217 9e-57 5HI2-A nrPDB 217 1e-56 4XUF-A nrPDB 216 2e-56 1FVR-A nrPDB 216 2e-56 4XCU-A nrPDB 216 2e-56 2W1I-A nrPDB 215 5e-56 2PSQ-A nrPDB 215 5e-56 1S9I-A nrPDB 215 5e-56 6O6Q-A nrPDB 215 5e-56 3QGY-A nrPDB 215 5e-56 3ORP-A nrPDB 214 6e-56 5X8I-B nrPDB 214 7e-56 6FER-A nrPDB 214 7e-56 1ZXE-A nrPDB 214 7e-56 4PDO-A nrPDB 214 8e-56 5HIE-A nrPDB 214 8e-56 3NIE-A nrPDB 214 8e-56 5FM2-A nrPDB 214 9e-56 5TQX-A nrPDB 214 1e-55 6E4F-A nrPDB 214 1e-55 3G0E-A nrPDB 213 2e-55 4HZS-A nrPDB 213 2e-55 4K33-A nrPDB 212 3e-55 6FYV-A nrPDB 212 3e-55 1AD5-A nrPDB 212 3e-55 3KUL-B nrPDB 212 4e-55 3ZBF-A nrPDB 212 4e-55 3N9X-A nrPDB 212 5e-55 2I6L-A nrPDB 211 5e-55 1U54-B nrPDB 211 6e-55 3DLS-A nrPDB 211 7e-55 4X7Q-B nrPDB 211 8e-55 3CJF-A nrPDB 210 9e-55 3SXS-A nrPDB 210 1e-54 4PWN-A nrPDB 210 1e-54 3E3P-A nrPDB 210 2e-54 4XI2-A nrPDB 210 2e-54 4E20-A nrPDB 209 2e-54 5EG3-A nrPDB 209 2e-54 4YFF-A nrPDB 209 3e-54 5ZTN-A nrPDB 209 4e-54 3RP9-A nrPDB 208 4e-54 4M7I-A nrPDB 208 5e-54 4KIK-B nrPDB 208 5e-54 5VD3-A nrPDB 208 6e-54 3BBT-B nrPDB 208 7e-54 2A1A-B nrPDB 207 8e-54 3QA8-A nrPDB 207 8e-54 6CTH-A nrPDB 207 8e-54 4Y83-A nrPDB 207 1e-53 5U6B-A nrPDB 207 1e-53 4Y93-A nrPDB 207 1e-53 3PP0-A nrPDB 206 2e-53 5U6C-A nrPDB 206 2e-53 5UIU-A nrPDB 205 3e-53 3IO7-A nrPDB 205 5e-53 3LZB-A nrPDB 203 1e-52 5GNK-A nrPDB 203 2e-52 2WO6-A nrPDB 203 2e-52 5HVK-A nrPDB 202 2e-52 4OW8-A nrPDB 202 2e-52 4X3F-A nrPDB 202 3e-52 6B2Q-A nrPDB 202 3e-52 5AP3-A nrPDB 202 3e-52 3UIU-A nrPDB 202 3e-52 6J5U-C nrPDB 202 4e-52 5TOS-A nrPDB 201 5e-52 1U59-A nrPDB 201 7e-52 6GVJ-A nrPDB 200 1e-51 5HLW-A nrPDB 200 1e-51 3HMP-A nrPDB 200 1e-51 4HVI-A nrPDB 200 1e-51 6DBN-A nrPDB 200 2e-51 4MD7-E nrPDB 199 4e-51 2OZO-A nrPDB 198 5e-51 5O0Y-A nrPDB 197 8e-51 4TPT-A nrPDB 197 8e-51 3AOX-A nrPDB 197 9e-51 2ZMD-A nrPDB 197 9e-51 2PVN-A nrPDB 197 1e-50 5LPZ-A nrPDB 197 1e-50 3PLS-A nrPDB 197 1e-50 5LPV-A nrPDB 197 1e-50 3C1X-A nrPDB 197 2e-50 3EB0-A nrPDB 196 2e-50 3UIM-A nrPDB 196 2e-50 4JLC-A nrPDB 195 3e-50 2RIO-A nrPDB 195 4e-50 4IDT-A nrPDB 195 4e-50 4F0G-A nrPDB 195 4e-50 4LRM-A nrPDB 195 5e-50 4EUU-A nrPDB 194 9e-50 4EUT-A nrPDB 194 9e-50 2PMN-X nrPDB 194 1e-49 3RAW-A nrPDB 193 2e-49 5UNP-A nrPDB 192 3e-49 4C59-A nrPDB 191 7e-49 6NT9-A nrPDB 191 8e-49 6O8B-A nrPDB 190 1e-48 4G3E-A nrPDB 190 1e-48 2QKW-B nrPDB 190 2e-48 6EII-A nrPDB 190 2e-48 6HMD-A nrPDB 189 4e-48 4NEU-A nrPDB 188 6e-48 2BUJ-A nrPDB 186 2e-47 3LLT-A nrPDB 186 2e-47 5XVU-A nrPDB 185 3e-47 4FL3-A nrPDB 184 9e-47 5WNO-A nrPDB 183 2e-46 2H34-A nrPDB 183 2e-46 5C26-A nrPDB 182 3e-46 5WNL-A nrPDB 182 5e-46 6HV0-A nrPDB 181 5e-46 4PL5-B nrPDB 180 9e-46 5TE0-A nrPDB 180 1e-45 5XD6-A nrPDB 179 2e-45 5IKW-A nrPDB 179 3e-45 3ZZW-A nrPDB 179 3e-45 4CRL-A nrPDB 179 4e-45 3QD2-B nrPDB 178 8e-45 5AR8-A nrPDB 177 1e-44 2JD5-A nrPDB 177 1e-44 6BFN-A nrPDB 175 5e-44 3LMG-A nrPDB 175 5e-44 4LQP-A nrPDB 174 7e-44 5VC6-A nrPDB 173 2e-43 4IAN-A nrPDB 172 3e-43 5VDK-A nrPDB 169 2e-42 3Q4U-A nrPDB 169 5e-42 4LFI-A nrPDB 168 6e-42 3MDY-A nrPDB 167 1e-41 3SV0-A nrPDB 165 3e-41 4M66-A nrPDB 165 4e-41 3MY0-A nrPDB 165 5e-41 2Y4I-B nrPDB 165 6e-41 5L2Q-C nrPDB 165 6e-41 6DC0-A nrPDB 161 9e-40 5CEK-A nrPDB 161 9e-40 4TN6-A nrPDB 161 1e-39 1PY5-A nrPDB 159 2e-39 4BTK-A nrPDB 158 7e-39 4NFN-A nrPDB 157 1e-38 4F9B-A nrPDB 157 2e-38 3SOC-A nrPDB 155 4e-38 5M07-A nrPDB 153 2e-37 5E8V-A nrPDB 153 2e-37 3G2F-A nrPDB 153 2e-37 5X18-A nrPDB 152 3e-37 2CHL-A nrPDB 152 5e-37 2CMW-A nrPDB 150 1e-36 4I94-A nrPDB 149 3e-36 2C47-A nrPDB 148 7e-36 3REP-A nrPDB 148 8e-36 4RT7-A nrPDB 144 1e-34 4XHH-A nrPDB 143 2e-34 4NT4-A nrPDB 143 2e-34 3HNG-A nrPDB 143 3e-34 5J0A-A nrPDB 143 3e-34 3VHK-A nrPDB 142 4e-34 4XHL-A nrPDB 142 5e-34 2QLU-A nrPDB 141 9e-34 1CSN-A nrPDB 140 2e-33 2PZI-A nrPDB 139 3e-33 4Y12-A nrPDB 138 4e-33 5OAT-A nrPDB 129 3e-30 6J6I-B nrPDB 125 5e-29 4L68-A nrPDB 122 5e-28 4JRN-A nrPDB 121 9e-28 6EQI-C nrPDB 113 1e-25 6EWX-A nrPDB 103 2e-22 5CLR-A nrPDB 103 3e-22 5DMZ-A nrPDB 98 1e-20 Sequences not found previously or not previously below threshold: 5O2B-A nrPDB 207 7e-54 5O2C-A nrPDB 205 3e-53 2WTK-B nrPDB 163 2e-40 2X7G-A nrPDB 160 2e-39 4WUA-A nrPDB 158 5e-39 5FQD-C nrPDB 153 2e-37 5X1R-A nrPDB 136 3e-32 4MWI-A nrPDB 134 9e-32 4M69-B nrPDB 133 2e-31 4BTF-A nrPDB 133 3e-31 5USZ-A nrPDB 128 6e-30 4L00-A nrPDB 127 1e-29 4WOV-A nrPDB 115 7e-26 5C01-A nrPDB 113 3e-25 5UV4-A nrPDB 107 1e-23 5UU1-A nrPDB 97 1e-20 2RSV-A nrPDB 90 3e-18 2LAV-A nrPDB 89 4e-18 6EAS-A nrPDB 86 5e-17 4O1O-A nrPDB 85 6e-17 6BHC-A nrPDB 84 1e-16 4IX6-A nrPDB 80 2e-15 6M7Z-A nrPDB 77 3e-14 4OAU-C nrPDB 76 4e-14 6G4J-A nrPDB 76 5e-14 4CI6-B nrPDB 75 1e-13 2JII-A nrPDB 72 5e-13 5VE6-A nrPDB 69 4e-12 5GZ9-A nrPDB 66 5e-11 5GZA-A nrPDB 64 2e-10 3BYV-A nrPDB 62 7e-10 4CYJ-A nrPDB 60 2e-09 2W1Z-A nrPDB 59 6e-09 3DZO-A nrPDB 58 1e-08 6G38-A nrPDB 58 1e-08 4AZW-A nrPDB 55 6e-08 4AZV-A nrPDB 55 8e-08 4CZY-B nrPDB 53 4e-07 3ENH-A nrPDB 52 9e-07 3Q60-A nrPDB 52 1e-06 6R5K-O nrPDB 51 1e-06 4WWA-A nrPDB 50 2e-06 4XR7-L nrPDB 50 2e-06 4BWP-A nrPDB 49 6e-06 1TQM-A nrPDB 44 2e-04 5YK0-A nrPDB 40 0.002 6FDN-A nrPDB 40 0.004 6G18-v nrPDB 39 0.004 6FAI-l nrPDB 39 0.006 4BVU-A nrPDB 36 0.048 6DFL-A nrPDB 36 0.052 2BV1-A nrPDB 34 0.19 3LV4-A nrPDB 32 0.80 >3NYO-A nrPDB Length = 576 Score = 878 bits (2268), Expect = 0.0, Method: Composition-based stats. Identities = 575/575 (100%), Positives = 575/575 (100%) Query: 2 ELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQP 61 ELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQP Sbjct: 2 ELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQP 61 Query: 62 IGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPEV 121 IGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPEV Sbjct: 62 IGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPEV 121 Query: 122 PRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPV 181 PRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPV Sbjct: 122 PRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPV 181 Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV Sbjct: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED Sbjct: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER 361 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER Sbjct: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER 361 Query: 362 YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCS 421 YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCS Sbjct: 362 YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCS 421 Query: 422 QLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIE 481 QLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIE Sbjct: 422 QLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIE 481 Query: 482 QFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWKG 541 QFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWKG Sbjct: 482 QFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWKG 541 Query: 542 QPPAPPKKGLLQRLFSRQDCCGNCSDSEEELPTRL 576 QPPAPPKKGLLQRLFSRQDCCGNCSDSEEELPTRL Sbjct: 542 QPPAPPKKGLLQRLFSRQDCCGNCSDSEEELPTRL 576 >4TNB-A nrPDB Length = 590 Score = 746 bits (1927), Expect = 0.0, Method: Composition-based stats. Identities = 403/559 (72%), Positives = 470/559 (84%), Gaps = 1/559 (0%) Query: 1 MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ 60 MELENIVANTVLLKAREGGGG RKGKSKKW+++L+FPHISQCE+LR +++RDY SLC++Q Sbjct: 1 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ 60 Query: 61 PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE 120 PIGRLLFR+FC TRP L + FLD VAEYEVTPD+K G+++ +L+ P I + Sbjct: 61 PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKKIMTKYLTPKSPVFIAQ 120 Query: 121 VPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQP 180 V + LV+ ++L Q PCK+LF + HEYL PF +YLDS++F+RFLQWKWLERQP Sbjct: 121 VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQP 180 Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACK+LEKKRIKKRKGE+MALNEKQILEK Sbjct: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK 240 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 VNS+FVV+LAYAYETKDALCLVLT+MNGGDLKFHIY+MG GF E RA+FYAAEI CGLE Sbjct: 241 VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE 300 Query: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE 360 DLH E VYRDLKPENILLDD+GHIRISDLGLAV +PEG I+GRVGTVGYMAPEV+ N+ Sbjct: 301 DLHHENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360 Query: 361 RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC 420 RY SPD+W LGCL+YEMI GQSPF+ RK+K+KREEV+R V E E YS +FS +A+S+C Sbjct: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC 420 Query: 421 SQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDI 480 LL KD +RLGC+ A EVK HP F+ +NFKRL AGML+PPF PDP+A+YCKDVLDI Sbjct: 421 KMLLTKDAKQRLGCQEEEAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI 480 Query: 481 EQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWK 540 EQFSTVKGV L+ TD DFY KF+TGSV IPWQNEM+ETECF+ELNVFG +G++PPDL+ + Sbjct: 481 EQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLN-R 539 Query: 541 GQPPAPPKKGLLQRLFSRQ 559 PP PPKKGLLQRLF RQ Sbjct: 540 NHPPEPPKKGLLQRLFKRQ 558 >4YHJ-A nrPDB Length = 584 Score = 729 bits (1883), Expect = 0.0, Method: Composition-based stats. Identities = 374/560 (66%), Positives = 445/560 (79%), Gaps = 2/560 (0%) Query: 1 MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ 60 MELENIVAN++LLKAR+GG G + G+SKKW+++L P +SQC ELR S+E+DY SLC++Q Sbjct: 1 MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60 Query: 61 PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE 120 PIGR LFR+FC T+P L R + FLD VAEYEV D+ R CG + F + +PE Sbjct: 61 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120 Query: 121 VPRQLVTNCTQRL-EQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQ 179 +P +VT C L E+ P K F+E TR+ H YL PF +Y +S YF++FLQWKWLERQ Sbjct: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180 Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 PVTKNTFR YRVLGKGGFGEVCACQVRATGKMYACKKL+KKRIKKRKGEAMALNEK+ILE Sbjct: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 KV SRFVVSLAYAYETKDALCLVLT+MNGGDLKFHIY++G GF E RAVFYAAE+CCGL Sbjct: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359 EDL RERIVYRDLKPENILLDD GHIRISDLGLA +PEGQ ++GRVGTVGYMAPEVV N Sbjct: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360 Query: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419 E+YTFSPDWW LGCL+YEMI G SPF++ K+K+K EEV++ +K EEYSE+FS A+S+ Sbjct: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420 Query: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLD 479 C LL K+P++RLGCRG A VK+HP+FK +NF+RL A MLEPPF PDP A+YCKDVLD Sbjct: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 480 Query: 480 IEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDW 539 IEQFS VKG+ L+ D+DFY +FATG V IPWQNEM+E+ CF+++N + ++P DLD Sbjct: 481 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK 540 Query: 540 KGQPPAP-PKKGLLQRLFSR 558 P P +G RLF R Sbjct: 541 NIHTPVSRPNRGFFYRLFRR 560 >3C51-A nrPDB Length = 543 Score = 620 bits (1600), Expect = e-178, Method: Composition-based stats. Identities = 255/534 (47%), Positives = 353/534 (66%), Gaps = 9/534 (1%) Query: 3 LENIVANTVLLKAREG--GGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ 60 LE +VAN+ + AR + +K+ L+ P +S+CE LR SL+ + +C Q Sbjct: 6 LETVVANSAFIAARGSFDASSGPASRDRKYLARLKLPPLSKCEALRESLDLGFEGMCLEQ 65 Query: 61 PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE 120 PIG+ LF++F T + + + +Y+ D R + L +L Sbjct: 66 PIGKRLFQQFLRTHEQHGPALQLWKDIEDYDTADDALRPQKAQALRAAYLEPQAQLFCSF 125 Query: 121 VPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQP 180 + + V R G LFQ L R +L APF ++LDS+YF RFLQWKWLE QP Sbjct: 126 LDAETVA----RARAGAGDGLFQPLLRAVLAHLGQAPFQEFLDSLYFLRFLQWKWLEAQP 181 Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 + ++ F +RVLG+GGFGEV ACQ++ATGK+YACKKL KKR+KKRKG A+ EK+IL K Sbjct: 182 MGEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAK 241 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQ--AGFPEARAVFYAAEICCG 298 V+SRF+VSLAYA+ETK LCLV+T+MNGGD+++HIY++ + GF E RA+FY A+I G Sbjct: 242 VHSRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSG 301 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT-IKGRVGTVGYMAPEVV 357 LE LH+ I+YRDLKPEN+LLDD G++RISDLGLAV + GQT KG GT G+MAPE++ Sbjct: 302 LEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELL 361 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 E Y FS D++ALG LYEMIA + PF+ R +K++ +E+++ V E Y ++FSP ++ Sbjct: 362 LGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASK 421 Query: 418 SLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDV 477 C LL KDP +RLG R GS ++ HPLF+ +++++L AGML PPF PD + +Y K++ Sbjct: 422 DFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDSRTVYAKNI 481 Query: 478 LDIEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDG 531 D+ FSTVKGV E D +F+Q+FA+G+ PIPWQ EM+ET F +LNV+ DG Sbjct: 482 QDVGAFSTVKGVAFEKADTEFFQEFASGTCPIPWQEEMIETGVFGDLNVWRPDG 535 >3PVW-A nrPDB Length = 695 Score = 517 bits (1332), Expect = e-147, Method: Composition-based stats. Identities = 203/542 (37%), Positives = 298/542 (54%), Gaps = 30/542 (5%) Query: 2 ELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCER-- 59 +LE ++A+ L A E ++ K + +L P I ++ LE E+ Sbjct: 3 DLEAVLADVSYLMAMEKSKATPAARASK-KILLPEPSIRSV--MQKYLEDRGEVTFEKIF 59 Query: 60 -QPIGRLLFREFCATRPELS-RCVAFLDGVAEYE-VTPDDKRKACGRQLTQNFLSHTGPD 116 Q +G LLFR+FC E + V F + + +YE + +++R C R++ ++ + Sbjct: 60 SQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYI---MKE 116 Query: 117 LIPEVPRQLVTNCTQRLEQGPCK-----DLFQELTRLTHEYLSVAPFADYLDSIYFNRFL 171 L+ + + ++ K DLFQ + L F +++S F RF Sbjct: 117 LLA-CSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFC 175 Query: 172 QWKWLERQ-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAM 230 QWK +E +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK ++GE + Sbjct: 176 QWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETL 235 Query: 231 ALNEKQILEKV---NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEAR 287 ALNE+ +L V + F+V ++YA+ T D L +L LMNGGDL +H+ G F EA Sbjct: 236 ALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFSEAD 293 Query: 288 AVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVG 347 FYAAEI GLE +H +VYRDLKP NILLD+HGH+RISDLGLA + + VG Sbjct: 294 MRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK-KKPHASVG 352 Query: 348 TVGYMAPEVVK-NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPE 406 T GYMAPEV++ Y S DW++LGC+L++++ G SPF+Q K K K E ++R+ + Sbjct: 353 THGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE-IDRMTLTMAV 411 Query: 407 EYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFK 466 E + FSP+ RSL LL +D RLGC G A+EVKE P F+ L+++ + PP Sbjct: 412 ELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLI 471 Query: 467 PDPQAIYCKDVLDIEQFS--TVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQEL 524 P + D DI F KG++L +DQ+ Y+ F ++ WQ E+ ET F + Sbjct: 472 PPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET-VFDTI 529 Query: 525 NV 526 N Sbjct: 530 NA 531 >5UUU-A nrPDB Length = 547 Score = 506 bits (1303), Expect = e-143, Method: Composition-based stats. Identities = 204/535 (38%), Positives = 296/535 (55%), Gaps = 30/535 (5%) Query: 9 NTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCER---QPIGRL 65 N A E GG ++ K + +L P I ++ LE E+ Q +G L Sbjct: 19 NLYFQGAMEPGGSTPAARASK-KILLPEPSIRSV--MQKYLEDRGEVTFEKIFSQKLGYL 75 Query: 66 LFREFCATRPELSR-CVAFLDGVAEYE-VTPDDKRKACGRQLTQNFLSHTGPDLIPEVPR 123 LFR+FC E +R V F + + +YE + +++R A R++ +++ +L+ Sbjct: 76 LFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYI---MKELLA-CSH 131 Query: 124 QLVTNCTQRLEQGPCK-----DLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLER 178 + T+ ++ K DLFQ + L F +++S F RF QWK +E Sbjct: 132 PFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVEL 191 Query: 179 Q-PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQI 237 +T N F +R++G+GGFGEV C+ TGKMYA K L+KKRIK ++GE +ALNE+ + Sbjct: 192 NIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIM 251 Query: 238 LEKV---NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAE 294 L V + F+V ++YA+ T D L +L LMNGGDL +H+ G F EA FYAAE Sbjct: 252 LSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFSEADMRFYAAE 309 Query: 295 ICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAP 354 I GLE +H +VYRDLKP NILLD+HGH+RISDLGLA + + VGT GYMAP Sbjct: 310 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK-KKPHASVGTHGYMAP 368 Query: 355 EVVK-NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFS 413 EV++ Y S DW++LGC+L++++ G SPF+Q K K K E ++R+ + E + FS Sbjct: 369 EVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHE-IDRMTLTMAVELPDSFS 427 Query: 414 PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIY 473 P+ RSL LL +D RLGC G A+EVKE P F+ L+++ + PP P + Sbjct: 428 PELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVN 487 Query: 474 CKDVLDIEQFS--TVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNV 526 D DI F KG++L +DQ+ Y+ F ++ WQ E+ ET F +N Sbjct: 488 AADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET-VFDTINA 540 >2JDO-A nrPDB Length = 342 Score = 357 bits (917), Expect = 6e-99, Method: Composition-based stats. Identities = 127/349 (36%), Positives = 187/349 (53%), Gaps = 13/349 (3%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 VT N F ++LGKG FG+V + +ATG+ YA K L K+ I + A + E ++L+ Sbjct: 6 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ 65 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 F+ +L YA++T D LC V+ NGG+L FH+ + F E RA FY AEI L Sbjct: 66 NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSR--ERVFTEERARFYGAEIVSAL 123 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVH-VPEGQTIKGRVGTVGYMAPEVVK 358 E LH +VYRD+K EN++LD GHI+I+D GL + +G T+K GT Y+APEV++ Sbjct: 124 EYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLE 183 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARS 418 + Y + DWW LG ++YEM+ G+ PF + E + L+ + SP+A+S Sbjct: 184 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQD----HERLFELILMEEIRFPRTLSPEAKS 239 Query: 419 LCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVL 478 L + LL KDP +RLG A+EV EH F +N++ + L PPFKP Q D Sbjct: 240 LLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKP--QVTSEVDTR 297 Query: 479 DIEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVF 527 + T + + + P D+ Y + + EM E F + + Sbjct: 298 YFDDEFTAQSITITPPDR--YDSLGLLELDQREEQEMFED--FDYIADW 342 >3MV5-A nrPDB Length = 342 Score = 355 bits (910), Expect = 4e-98, Method: Composition-based stats. Identities = 121/320 (37%), Positives = 181/320 (56%), Gaps = 10/320 (3%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 VT N F ++LGKG FG+V + +ATG+ YA K L+K+ I + A L E ++L+ Sbjct: 6 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ 65 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 F+ +L Y+++T D LC V+ NGG+L FH+ + F E RA FY AEI L Sbjct: 66 NSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSAL 123 Query: 300 EDLHR-ERIVYRDLKPENILLDDHGHIRISDLGLAVH-VPEGQTIKGRVGTVGYMAPEVV 357 + LH + +VYRDLK EN++LD GHI+I+D GL + +G T+K GT Y+APEV+ Sbjct: 124 DYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 183 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 ++ Y + DWW LG ++YEM+ G+ PF + E++ L+ + P+A+ Sbjct: 184 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQD----HEKLFELILMEEIRFPRTLGPEAK 239 Query: 418 SLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDV 477 SL S LL KDP +RLG A+E+ +H F + ++ + L PPFKP Q D Sbjct: 240 SLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP--QVTSETDT 297 Query: 478 LDIEQFSTVKGVELEPTDQD 497 ++ T + + + P DQD Sbjct: 298 RYFDEEFTAQMITITPPDQD 317 >5KCV-A nrPDB Length = 460 Score = 343 bits (879), Expect = 2e-94, Method: Composition-based stats. Identities = 121/352 (34%), Positives = 186/352 (52%), Gaps = 14/352 (3%) Query: 139 KDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFG 198 D ++ ++ S +P D+ + VT N F ++LGKG FG Sbjct: 121 ADGLKKQAAAEMDFRSGSP----SDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFG 176 Query: 199 EVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDA 258 +V + +ATG+ YA K L+K+ I + A L E ++L+ F+ +L Y+++T D Sbjct: 177 KVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDR 236 Query: 259 LCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR-ERIVYRDLKPENI 317 LC V+ NGG+L FH+ + F E RA FY AEI L+ LH + +VYRDLK EN+ Sbjct: 237 LCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENL 294 Query: 318 LLDDHGHIRISDLGLAVH-VPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLY 376 +LD GHI+I+D GL + +G T+K GT Y+APEV+++ Y + DWW LG ++Y Sbjct: 295 MLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMY 354 Query: 377 EMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRG 436 EM+ G+ PF + E++ L+ + P+A+SL S LL KDP +RLG Sbjct: 355 EMMCGRLPFYNQD----HEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGS 410 Query: 437 GSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKG 488 A+E+ +H F + ++ + L PPFKP Q D ++ T + Sbjct: 411 EDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP--QVTSETDTRYFDEEFTAQM 460 >4RA4-A nrPDB Length = 355 Score = 340 bits (871), Expect = 2e-93, Method: Composition-based stats. Identities = 120/325 (36%), Positives = 180/325 (55%), Gaps = 11/325 (3%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 V F VLGKG FG+V + T ++YA K L+K + + + EK++L Sbjct: 15 DRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVL 74 Query: 239 EKVNSR-FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 ++ F+ L ++T D L V+ +NGGDL +HI +G+ F E +AVFYAAEI Sbjct: 75 ALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGK--FKEPQAVFYAAEISI 132 Query: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAV-HVPEGQTIKGRVGTVGYMAPEV 356 GL LH+ I+YRDLK +N++LD GHI+I+D G+ H+ +G T + GT Y+APE+ Sbjct: 133 GLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEI 192 Query: 357 VKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQA 416 + + Y S DWWA G LLYEM+AGQ PF + + + E Y + S +A Sbjct: 193 IAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIM----EHNVSYPKSLSKEA 248 Query: 417 RSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKD 476 S+C L+ K PA+RLGC R+V+EH F+++++++L ++PPFKP + K Sbjct: 249 VSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPK---VSGKG 305 Query: 477 VLDIEQFSTVKGVELEPTDQDFYQK 501 + ++F T L P DQ Sbjct: 306 AENFDKFFTRGQPVLTPPDQLVIAN 330 >3PFQ-A nrPDB Length = 674 Score = 336 bits (862), Expect = 1e-92, Method: Composition-based stats. Identities = 123/364 (33%), Positives = 195/364 (53%), Gaps = 15/364 (4%) Query: 140 DLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGE 199 +L Q+ R + AP ++I ++F +R +T F VLGKG FG+ Sbjct: 301 ELRQKFERAKIGQGTKAPEEKTANTI--SKFDNNGNRDRMKLT--DFNFLMVLGKGSFGK 356 Query: 200 VCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR-FVVSLAYAYETKDA 258 V + + T ++YA K L+K + + + EK++L F+ L ++T D Sbjct: 357 VMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDR 416 Query: 259 LCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENIL 318 L V+ +NGGDL +HI +G+ F E AVFYAAEI GL L + I+YRDLK +N++ Sbjct: 417 LYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVM 474 Query: 319 LDDHGHIRISDLGLAVH-VPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYE 377 LD GHI+I+D G+ + +G T K GT Y+APE++ + Y S DWWA G LLYE Sbjct: 475 LDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYE 534 Query: 378 MIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGG 437 M+AGQ+PF+ + + + E Y + S +A ++C L+ K P +RLGC Sbjct: 535 MLAGQAPFEGEDEDELFQSIM----EHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPE 590 Query: 438 SAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEPTDQD 497 R++KEH F+ +++++L ++PP+KP ++ + ++F T L P DQ+ Sbjct: 591 GERDIKEHAFFRYIDWEKLERKEIQPPYKPKAS---GRNAENFDRFFTRHPPVLTPPDQE 647 Query: 498 FYQK 501 + Sbjct: 648 VIRN 651 >4L42-A nrPDB Length = 346 Score = 334 bits (857), Expect = 6e-92, Method: Composition-based stats. Identities = 118/331 (35%), Positives = 178/331 (53%), Gaps = 20/331 (6%) Query: 184 NTFRQYRVLGKGGFGEVCACQVR---ATGKMYACKKLEKKRI-KKRKGEAMALNEKQILE 239 F RVLGKGG+G+V + TGK++A K L+K I + K A E+ ILE Sbjct: 18 ECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE 77 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 +V F+V L YA++T L L+L ++GG+L + G F E A FY AEI L Sbjct: 78 EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREG--IFMEDTACFYLAEISMAL 135 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVH-VPEGQTIKGRVGTVGYMAPEVVK 358 LH++ I+YRDLKPENI+L+ GH++++D GL + +G GT+ YMAPE++ Sbjct: 136 GHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 195 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARS 418 + + DWW+LG L+Y+M+ G PF +K +++ + +P + +AR Sbjct: 196 RSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPP----YLTQEARD 251 Query: 419 LCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVL 478 L +LL ++ A RLG G A EV+ HP F+ +N++ L A +EPPFKP Q+ Sbjct: 252 LLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQF 311 Query: 479 DIEQFSTVKGVELEPTD-------QDFYQKF 502 D + T + P D Q+ ++ F Sbjct: 312 DSK--FTRQTPVDSPDDSTLSEEEQEMFRDF 340 >2I0E-A nrPDB Length = 353 Score = 334 bits (856), Expect = 7e-92, Method: Composition-based stats. Identities = 115/326 (35%), Positives = 179/326 (54%), Gaps = 11/326 (3%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQI 237 R + F VLGKG FG+V + + T ++YA K L+K + + + EK++ Sbjct: 14 RDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 73 Query: 238 LEKVNSR-FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 L F+ L ++T D L V+ +NGGDL +HI +G+ F E AVFYAAEI Sbjct: 74 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIA 131 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVH-VPEGQTIKGRVGTVGYMAPE 355 GL L + I+YRDLK +N++LD GHI+I+D G+ + +G T K GT Y+APE Sbjct: 132 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 191 Query: 356 VVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQ 415 ++ + Y S DWWA G LLYEM+AGQ+PF+ + + + E Y + S + Sbjct: 192 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM----EHNVAYPKSMSKE 247 Query: 416 ARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCK 475 A ++C L+ K P +RLGC R++KEH F+ +++++L ++PP+KP + Sbjct: 248 AVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKA---CGR 304 Query: 476 DVLDIEQFSTVKGVELEPTDQDFYQK 501 + + ++F T L P DQ+ + Sbjct: 305 NAENFDRFFTRHPPVLTPPDQEVIRN 330 >1FOT-A nrPDB Length = 318 Score = 331 bits (848), Expect = 6e-91, Method: Composition-based stats. Identities = 107/321 (33%), Positives = 167/321 (52%), Gaps = 10/321 (3%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 F+ R LG G FG V + R G+ YA K L+K+ + + K +E+ +L V Sbjct: 6 QDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTH 65 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 F++ + ++ + +++ + GG+L + + FP A FYAAE+C LE LH Sbjct: 66 PFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQR--FPNPVAKFYAAEVCLALEYLH 123 Query: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYT 363 + I+YRDLKPENILLD +GHI+I+D G A +VP+ GT Y+APEVV + Y Sbjct: 124 SKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPD--VTYTLCGTPDYIAPEVVSTKPYN 181 Query: 364 FSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQL 423 S DWW+ G L+YEM+AG +PF E++ P F+ + L S+L Sbjct: 182 KSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPP----FFNEDVKDLLSRL 237 Query: 424 LCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDP-QAIYCKDVLD-IE 481 + +D ++RLG +VK HP FK++ +++L + +E P++P Q D Sbjct: 238 ITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEPPIQQGQGDTSQFDKYP 297 Query: 482 QFSTVKGVELEPTDQDFYQKF 502 + GV+ E D ++ F Sbjct: 298 EEDINYGVQGEDPYADLFRDF 318 >5F9E-A nrPDB Length = 353 Score = 328 bits (842), Expect = 3e-90, Method: Composition-based stats. Identities = 110/332 (33%), Positives = 179/332 (53%), Gaps = 18/332 (5%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 + F +++LGKG FG+V + + T + +A K L+K + + EK++L Sbjct: 15 KLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLS 74 Query: 240 KV-NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 F+ + ++TK+ L V+ +NGGDL +HI + F +RA FYAAEI G Sbjct: 75 LAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHK--FDLSRATFYAAEIILG 132 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKG-RVGTVGYMAPEVV 357 L+ LH + IVYRDLK +NILLD GHI+I+D G+ G GT Y+APE++ Sbjct: 133 LQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEIL 192 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 ++Y S DWW+ G LLYEM+ GQSPF + + EE+ ++ Y +A+ Sbjct: 193 LGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDE----EELFHSIRMDNPFYPRWLEKEAK 248 Query: 418 SLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDV 477 L +L ++P +RLG RG ++++HPLF+++N++ L ++PPF+P ++ + Sbjct: 249 DLLVKLFVREPEKRLGVRG----DIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCSN 304 Query: 478 LDIE------QFSTVKGVELEPTDQDFYQKFA 503 D E + S + DQ+ ++ F+ Sbjct: 305 FDKEFLNEKPRLSFADRALINSMDQNMFRNFS 336 >3A8W-A nrPDB Length = 345 Score = 328 bits (842), Expect = 3e-90, Method: Composition-based stats. Identities = 112/331 (33%), Positives = 177/331 (53%), Gaps = 12/331 (3%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 P+ F RV+G+G + +V +++ T ++YA K ++K+ + + EK + Sbjct: 4 DPLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVF 63 Query: 239 EKV-NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 E+ N F+V L ++T+ L V+ +NGGDL FH+ Q PE A FY+AEI Sbjct: 64 EQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQR--QRKLPEEHARFYSAEISL 121 Query: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVH-VPEGQTIKGRVGTVGYMAPEV 356 L LH I+YRDLK +N+LLD GHI+++D G+ + G T GT Y+APE+ Sbjct: 122 ALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEI 181 Query: 357 VKNERYTFSPDWWALGCLLYEMIAGQSPFQ-----QRKKKIKREEVERLVKEVPEEYSER 411 ++ E Y FS DWWALG L++EM+AG+SPF + + + +++ E Sbjct: 182 LRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRS 241 Query: 412 FSPQARSLCSQLLCKDPAERLGCRGGS-AREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQ 470 S +A S+ L KDP ERLGC + +++ HP F+ +++ + + PPFKP+ Sbjct: 242 LSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNIS 301 Query: 471 AIYCKDVLDIEQFSTVKGVELEPTDQDFYQK 501 + D D + T + V+L P D D +K Sbjct: 302 GEFGLDNFDSQ--FTNEPVQLTPDDDDIVRK 330 >3TXO-A nrPDB Length = 353 Score = 328 bits (840), Expect = 6e-90, Method: Composition-based stats. Identities = 113/335 (33%), Positives = 166/335 (49%), Gaps = 19/335 (5%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 + + F RVLGKG FG+V +V+ TG +YA K L+K I + + EK+IL Sbjct: 18 NRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRIL 77 Query: 239 EKV-NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 N F+ L ++T D L V+ +NGGDL FHI + F EARA FYAAEI Sbjct: 78 SLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRR--FDEARARFYAAEIIS 135 Query: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVH-VPEGQTIKGRVGTVGYMAPEV 356 L LH + I+YRDLK +N+LLD GH +++D G+ + G T GT Y+APE+ Sbjct: 136 ALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEI 195 Query: 357 VKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQA 416 ++ Y + DWWA+G LLYEM+ G +PF+ + E + Y A Sbjct: 196 LQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAIL----NDEVVYPTWLHEDA 251 Query: 417 RSLCSQLLCKDPAERLGCRGGSARE-VKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCK 475 + + K+P RLG + HP FK++++ +L +EPPF+P ++ Sbjct: 252 TGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDV 311 Query: 476 DVLDIEQFSTVKGVELEPTD--------QDFYQKF 502 D + + L P D QD ++ F Sbjct: 312 SNFDPD--FIKEEPVLTPIDEGHLPMINQDEFRNF 344 >1VZO-A nrPDB Length = 355 Score = 327 bits (839), Expect = 7e-90, Method: Composition-based stats. Identities = 117/314 (37%), Positives = 173/314 (55%), Gaps = 16/314 (5%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQV---RATGKMYACKKLEKKRI-KKRKGEAMALNE 234 + V F +VLG G +G+V + TGK+YA K L+K I +K K E Sbjct: 49 EKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTE 108 Query: 235 KQILEKVN-SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAA 293 +Q+LE + S F+V+L YA++T+ L L+L +NGG+L H+ + F E Y Sbjct: 109 RQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRER--FTEHEVQIYVG 166 Query: 294 EICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV--PEGQTIKGRVGTVGY 351 EI LE LH+ I+YRD+K ENILLD +GH+ ++D GL+ E + GT+ Y Sbjct: 167 EIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEY 226 Query: 352 MAPEVVKNE--RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYS 409 MAP++V+ + + DWW+LG L+YE++ G SPF +K + E+ R + + Y Sbjct: 227 MAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYP 286 Query: 410 ERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDP 469 + S A+ L +LL KDP +RLGC A E+KEH F+K+N+ L A + PFKP Sbjct: 287 QEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKP-- 344 Query: 470 QAIYCKDVLDIEQF 483 +D LD+ F Sbjct: 345 ---VIRDELDVSNF 355 >5X3F-B nrPDB Length = 393 Score = 326 bits (837), Expect = 1e-89, Method: Composition-based stats. Identities = 106/370 (28%), Positives = 172/370 (46%), Gaps = 13/370 (3%) Query: 118 IPEVPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLE 177 +P + + V L P + L E + +L + +W+ Sbjct: 23 LPNLNGRQVAAFISSLLDDPSQS-----ANLLAEAKKLNDVQAFLAKAKEDFLKKWETPS 77 Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQI 237 + + F + + LG G FG V + + +G YA K L+K+++ K K LNEK+I Sbjct: 78 QNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRI 137 Query: 238 LEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 L+ VN F+V L ++++ L +V+ + GG++ H+ +G+ F E A FYAA+I Sbjct: 138 LQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGR--FSEPHARFYAAQIVL 195 Query: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVV 357 E LH ++YRDLKPEN+L+D G+I+++D G A V GT Y+APE++ Sbjct: 196 TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGR--TWTLCGTPEYLAPEII 253 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 ++ Y + DWWALG L+YEM AG PF + E++ P FS + Sbjct: 254 LSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFP----SHFSSDLK 309 Query: 418 SLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDV 477 L LL D +R G ++K H F ++ + +E PF P + Sbjct: 310 DLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSN 369 Query: 478 LDIEQFSTVK 487 D + ++ Sbjct: 370 FDDYEEEEIR 379 >5N23-A nrPDB Length = 352 Score = 326 bits (836), Expect = 1e-89, Method: Composition-based stats. Identities = 104/333 (31%), Positives = 163/333 (48%), Gaps = 7/333 (2%) Query: 155 VAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYAC 214 ++L + +W+ + + F + R LG G FG V + + TG YA Sbjct: 13 QESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIRTLGTGSFGRVMLVKHKETGNHYAM 72 Query: 215 KKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFH 274 K L+K+++ K K LNEK+I + VN F+V L ++++ L +VL GG++ H Sbjct: 73 KILDKQKVVKLKQIEHTLNEKRIQQAVNFPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSH 132 Query: 275 IYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAV 334 + +G+ F E A FYAA+I E LH ++YRDLKPEN+L+D G+I+++D G A Sbjct: 133 LRRIGR--FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAK 190 Query: 335 HVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKR 394 V G+T GT Y+APE++ ++ Y + DWWALG L+YEM AG PF + Sbjct: 191 RVK-GRTPWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIY 249 Query: 395 EEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFK 454 E++ P FS + L LL D +R G ++K H F ++ Sbjct: 250 EKIVSGKVRFP----SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWI 305 Query: 455 RLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVK 487 + +E PF P + D + ++ Sbjct: 306 AIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIR 338 >5D9K-A nrPDB Length = 330 Score = 326 bits (836), Expect = 2e-89, Method: Composition-based stats. Identities = 110/309 (35%), Positives = 162/309 (52%), Gaps = 13/309 (4%) Query: 185 TFRQYRVLGKGGFGEVCACQVR---ATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 F +VLG+G FG+V + ++YA K L+K +K R + E+ IL +V Sbjct: 31 QFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKM-ERDILVEV 89 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 N F+V L YA++T+ L L+L + GGDL + + F E FY AE+ L+ Sbjct: 90 NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK--EVMFTEEDVKFYLAELALALDH 147 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVH-VPEGQTIKGRVGTVGYMAPEVVKNE 360 LH I+YRDLKPENILLD+ GHI+++D GL+ + + GTV YMAPEVV Sbjct: 148 LHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRR 207 Query: 361 RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC 420 +T S DWW+ G L++EM+ G PFQ + +K + + +P + SP+A+SL Sbjct: 208 GHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMP----QFLSPEAQSLL 263 Query: 421 SQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDI 480 L ++PA RLG E+K H F +++ +L + PPFKP +D Sbjct: 264 RMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRP--EDTFYF 321 Query: 481 EQFSTVKGV 489 + T K Sbjct: 322 DPEFTAKTP 330 >4WB7-A nrPDB Length = 405 Score = 325 bits (834), Expect = 3e-89, Method: Composition-based stats. Identities = 110/395 (27%), Positives = 180/395 (45%), Gaps = 17/395 (4%) Query: 93 TPDDKRKACGRQLTQNFLSHTGPDLIPEVPRQLVTNCTQRLEQGPCKDLFQELTRLTHEY 152 D++ K R+ + + E + + L +++F E+ Sbjct: 14 ASDEEIKRAYRRQALRYHPDKNKEPGAEEKFKEIAEAYDVLSDPRKREIFDRYGEEVKEF 73 Query: 153 LSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMY 212 L D+L +W+ + + F + + LG G FG V + + TG Y Sbjct: 74 L-AKAKEDFLK--------KWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHY 124 Query: 213 ACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLK 272 A K L+K+++ K K LNEK+IL+ VN F+V L ++++ L +V+ + GG++ Sbjct: 125 AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMF 184 Query: 273 FHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGL 332 H+ +G+ F E A FYAA+I E LH ++YRDLKPEN+L+D G+I+++D G Sbjct: 185 SHLRRIGR--FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGF 242 Query: 333 AVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKI 392 A V GT Y+APE++ ++ Y + DWWALG L+YEM AG PF + Sbjct: 243 AKRVKGR--TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQ 300 Query: 393 KREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 E++ P FS + L LL D +R G ++K H F + Sbjct: 301 IYEKIVSGKVRFP----SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 356 Query: 453 FKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVK 487 + + +E PF P + D + ++ Sbjct: 357 WIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIR 391 >4RLP-A nrPDB Length = 288 Score = 324 bits (831), Expect = 6e-89, Method: Composition-based stats. Identities = 111/289 (38%), Positives = 165/289 (57%), Gaps = 11/289 (3%) Query: 184 NTFRQYRVLGKGGFGEVCACQVR---ATGKMYACKKLEKKRI-KKRKGEAMALNEKQILE 239 F RVLGKGG+G+V + TGK++A K L+K I + K A E+ ILE Sbjct: 5 ECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE 64 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 +V F+V L YA++T L L+L ++GG+L + G F E A FY AEI L Sbjct: 65 EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREG--IFMEDTACFYLAEISMAL 122 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVH-VPEGQTIKGRVGTVGYMAPEVVK 358 LH++ I+YRDLKPENI+L+ GH++++D GL + +G GT+ YMAPE++ Sbjct: 123 GHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 182 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARS 418 + + DWW+LG L+Y+M+ G PF +K +++ + +P + +AR Sbjct: 183 RSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPP----YLTQEARD 238 Query: 419 LCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKP 467 L +LL ++ A RLG G A EV+ HP F+ +N++ L A +EPPFKP Sbjct: 239 LLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP 287 >3HDN-A nrPDB Length = 373 Score = 321 bits (822), Expect = 7e-88, Method: Composition-based stats. Identities = 115/307 (37%), Positives = 158/307 (51%), Gaps = 11/307 (3%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL-EKVNS 243 F +V+GKG FG+V + +A YA K L+KK I K+K E ++E+ +L + V Sbjct: 39 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 98 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 F+V L ++++T D L VL +NGG+L +H+ + F E RA FYAAEI L LH Sbjct: 99 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQR--ERCFLEPRARFYAAEIASALGYLH 156 Query: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVH-VPEGQTIKGRVGTVGYMAPEVVKNERY 362 IVYRDLKPENILLD GHI ++D GL + T GT Y+APEV+ + Y Sbjct: 157 SLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPY 216 Query: 363 TFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQ 422 + DWW LG +LYEM+ G PF R + + P + + AR L Sbjct: 217 DRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNK----PLQLKPNITNSARHLLEG 272 Query: 423 LLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQ 482 LL KD +RLG + E+K H F +N+ L + PPF P+ D E Sbjct: 273 LLQKDRTKRLGAKD-DFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPE- 330 Query: 483 FSTVKGV 489 T + V Sbjct: 331 -FTEEPV 336 >2Z7Q-A nrPDB Length = 321 Score = 319 bits (818), Expect = 2e-87, Method: Composition-based stats. Identities = 109/300 (36%), Positives = 161/300 (53%), Gaps = 11/300 (3%) Query: 185 TFRQYRVLGKGGFGEVCACQVR---ATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 F +VLG+G FG+V + +G +YA K L+K +K R + E+ IL V Sbjct: 29 HFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKM-ERDILADV 87 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 N FVV L YA++T+ L L+L + GGDL + + F E FY AE+ GL+ Sbjct: 88 NHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK--EVMFTEEDVKFYLAELALGLDH 145 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVH-VPEGQTIKGRVGTVGYMAPEVVKNE 360 LH I+YRDLKPENILLD+ GHI+++D GL+ + + GTV YMAPEVV + Sbjct: 146 LHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQ 205 Query: 361 RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC 420 ++ S DWW+ G L++EM+ G PFQ + +K + + +P + S +A+SL Sbjct: 206 GHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMP----QFLSTEAQSLL 261 Query: 421 SQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDI 480 L ++PA RLG A E+K H + +++ +L ++PPFKP D Sbjct: 262 RALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFDT 321 >5JN2-A nrPDB Length = 525 Score = 318 bits (815), Expect = 4e-87, Method: Composition-based stats. Identities = 82/279 (29%), Positives = 146/279 (52%), Gaps = 11/279 (3%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 + + ++ RVLGKG FGEV C+ + TG+ A K + K+++K++ + L E Q+L++ Sbjct: 64 IFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQ 123 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 ++ ++ L +E K LV + GG+L I + F E A ++ G+ Sbjct: 124 LDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKR--FSEVDAARIIRQVLSGIT 181 Query: 301 DLHRERIVYRDLKPENILLDD---HGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVV 357 +H+ +IV+RDLKPEN+LL+ +IRI D GL+ H + +K ++GT Y+APEV+ Sbjct: 182 YMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVL 241 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 Y D W+ G +LY +++G PF + ++VE+ ++ S A+ Sbjct: 242 HGT-YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAK 300 Query: 418 SLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRL 456 L ++L P+ R+ SAR+ +H + +++ Sbjct: 301 DLIRKMLTYVPSMRI-----SARDALDHEWIQTYTKEQI 334 >3MA6-A nrPDB Length = 298 Score = 314 bits (804), Expect = 8e-86, Method: Composition-based stats. Identities = 84/294 (28%), Positives = 151/294 (51%), Gaps = 14/294 (4%) Query: 163 DSIYFNRFLQWKWLERQP-VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKR 221 +++YF +++ + + ++ RVLGKG FGEV C+ + TG+ A K + K++ Sbjct: 12 ENLYFQG--PGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQ 69 Query: 222 IKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQA 281 +K++ + L E Q+L++++ ++ L +E K LV + GG+L I + Sbjct: 70 VKQKTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKR- 128 Query: 282 GFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDD---HGHIRISDLGLAVHVPE 338 F E A ++ G+ +H+ +IV+RDLKPEN+LL+ +IRI D GL+ H Sbjct: 129 -FSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEA 187 Query: 339 GQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVE 398 + +K ++GT Y+APEV+ Y D W+ G +LY +++G PF + ++VE Sbjct: 188 SKKMKDKIGTAYYIAPEVLHGT-YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVE 246 Query: 399 RLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 + ++ S A+ L ++L P+ R+ SAR+ +H + Sbjct: 247 KGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRI-----SARDALDHEWIQTYT 295 >3DXN-A nrPDB Length = 287 Score = 312 bits (800), Expect = 2e-85, Method: Composition-based stats. Identities = 82/292 (28%), Positives = 140/292 (47%), Gaps = 23/292 (7%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI 222 +++YF + +++ + LG G +GEV C+ + TG A K ++K + Sbjct: 12 ENLYFQGL------------SDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSV 59 Query: 223 KKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG 282 L+E +L++++ ++ L +E K LV+ + GG+L I + Sbjct: 60 TTTSNSGALLDEVAVLKQLDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIIL--RQK 117 Query: 283 FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGH---IRISDLGLAVHVPEG 339 F E A ++ G LH+ IV+RDLKPEN+LL+ I+I D GL+ H G Sbjct: 118 FSEVDAAVIMKQVLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVG 177 Query: 340 QTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVER 399 +K R+GT Y+APEV++ ++Y D W+ G +LY ++ G PF + + + VE+ Sbjct: 178 GKMKERLGTAYYIAPEVLR-KKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEK 236 Query: 400 LVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 + S +A+ L +L +P++R+ SA E HP K Sbjct: 237 GKFSFDPPDWTQVSDEAKQLVKLMLTYEPSKRI-----SAEEALNHPWIVKF 283 >3HZT-A nrPDB Length = 467 Score = 312 bits (799), Expect = 3e-85, Method: Composition-based stats. Identities = 80/272 (29%), Positives = 135/272 (49%), Gaps = 11/272 (4%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 + +++ + LG G +GEV C+ + TG A K ++K + L+E +L++++ Sbjct: 3 SDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLD 62 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 ++ L +E K LV+ + GG+L I + F E A ++ G L Sbjct: 63 HPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIIL--RQKFSEVDAAVIMKQVLSGTTYL 120 Query: 303 HRERIVYRDLKPENILLDDHGH---IRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359 H+ IV+RDLKPEN+LL+ I+I D GL+ H G +K R+GT Y+APEV++ Sbjct: 121 HKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVLR- 179 Query: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419 ++Y D W+ G +LY ++ G PF + + + VE+ + S +A+ L Sbjct: 180 KKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQL 239 Query: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 +L +P++R+ SA E HP K Sbjct: 240 VKLMLTYEPSKRI-----SAEEALNHPWIVKF 266 >5FET-A nrPDB Length = 847 Score = 311 bits (796), Expect = 8e-85, Method: Composition-based stats. Identities = 103/362 (28%), Positives = 166/362 (45%), Gaps = 10/362 (2%) Query: 138 CKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGF 197 + + T + ++ + F + + ++ V + R++G+G F Sbjct: 487 TASIISKATSVECWFVDKSVFLQIIQGPMLTHLEERIKMQDTKVEMHELETERIIGRGTF 546 Query: 198 GEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKD 257 G V + T YA K + K+ I + E++I + + F++ L ++ + Sbjct: 547 GTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAENDHPFIIRLVRTFKDSN 606 Query: 258 ALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENI 317 + L+ GG+L I +G + +A FY I +E LH IVYRDLKPENI Sbjct: 607 CFYFLTELVTGGELYDAIRKLGL--LSKPQAQFYLGSIILAIEYLHERNIVYRDLKPENI 664 Query: 318 LLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYE 377 LLD G++++ D G A + VGT YMAPEV+ + Y + D WALG LYE Sbjct: 665 LLDKQGYVKLIDFGCAKKIQGRAY--TLVGTPHYMAPEVILGKGYGCTVDIWALGVCLYE 722 Query: 378 MIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSP-QARSLCSQLLCKDPAERLGCRG 436 I G PF ++ E+ R + + + S + +L +LLC+ P R+GC Sbjct: 723 FICGPLPFGNDQEDQL--EIFRDILTGQLTFPDYVSDQDSINLMKRLLCRLPQGRIGCSI 780 Query: 437 GSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGV-ELEPTD 495 +++KEH F N+ +L +LEPP Y +D+ DI+Q + E EP D Sbjct: 781 NGFKDIKEHAFFGNFNWDKLAGRLLEPPLVSK-GETYAEDI-DIKQIEEEDALNEGEPLD 838 Query: 496 QD 497 D Sbjct: 839 GD 840 >4MVF-A nrPDB Length = 506 Score = 309 bits (792), Expect = 2e-84, Method: Composition-based stats. Identities = 77/313 (24%), Positives = 142/313 (45%), Gaps = 23/313 (7%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 ++ + LG+G +G V + T ++YA K+ +K R+K E +I++K++ Sbjct: 56 EDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNIN---RFFQEIEIMKKLD 112 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 +V L YE + + L++ L +G +L I G F E A +I + L Sbjct: 113 HPNIVKLYETYENDNYIYLIMELCSGRELFDSIIENG--SFTEKNAATIMKQIFSAIFYL 170 Query: 303 HRERIVYRDLKPENILL---DDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359 H IV+RDLKPEN L + ++I D GL+ ++ G+ + GT Y+AP+V+ Sbjct: 171 HSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDG 230 Query: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419 +Y D W+ G ++Y ++ G PF ++V++ E S A++L Sbjct: 231 -KYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISSDAKNL 289 Query: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLD 479 ++LL +P ER + E HP ++ E + + K++ + Sbjct: 290 ITKLLTYNPNER-----CTIEEALNHPWITQMT------KSHEHV---ELSSTLLKNLKN 335 Query: 480 IEQFSTVKGVELE 492 ++ + +K + L Sbjct: 336 FKKENELKKIALT 348 >6BDL-A nrPDB Length = 347 Score = 309 bits (791), Expect = 3e-84, Method: Composition-based stats. Identities = 90/314 (28%), Positives = 153/314 (48%), Gaps = 9/314 (2%) Query: 185 TFRQYRVLGKGGFGEVCACQVR-ATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 F LG GGFG V Q++ K +A K L+K+ I + + +EKQI++ +S Sbjct: 35 DFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHS 94 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 F+V L ++ L +++ GG+L + G F ++ FY A + LH Sbjct: 95 DFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRG--SFEDSTTRFYTACVVEAFAYLH 152 Query: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYT 363 + I+YRDLKPEN++LD G+ ++ D G A + G+ GT Y+APE++ N+ + Sbjct: 153 SKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHD 212 Query: 364 FSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQL 423 S D+W+LG L+YE++ G PF + R + + E+ ++ + A +L +L Sbjct: 213 ISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMI--EFPKKIAKNAANLIKKL 270 Query: 424 LCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQF 483 +P+ERLG +++++H F+ N++ L G L PP P + D Sbjct: 271 CRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPE 330 Query: 484 STVKGVELEPTDQD 497 + P D + Sbjct: 331 DNDEP----PPDDN 340 >3TKU-A nrPDB Length = 433 Score = 308 bits (790), Expect = 3e-84, Method: Composition-based stats. Identities = 100/364 (27%), Positives = 180/364 (49%), Gaps = 30/364 (8%) Query: 145 LTRLTHEYLSVAPFADYLDSIYFNRFLQW-----KWLERQPVTKNTFRQYRVLGKGGFGE 199 T +H L Y FL+W + ++ + + F +V+G+G FGE Sbjct: 54 YTECSHSALRRDK--------YVAEFLEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGE 105 Query: 200 VCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDAL 259 V +++ T ++YA K L K + KR A E+ +L + +++ +L YA++ ++ L Sbjct: 106 VAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHL 165 Query: 260 CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILL 319 LV+ GGDL + + PE A FY E+ ++ +H+ V+RD+KP+N+LL Sbjct: 166 YLVMDYYVGGDLLTLLSKF-EDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLL 224 Query: 320 DDHGHIRISDLGLAVHVPEGQTIKGR--VGTVGYMAPEVVKN-----ERYTFSPDWWALG 372 D +GHIR++D G + + + T++ VGT Y++PE+++ +Y DWW+LG Sbjct: 225 DVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLG 284 Query: 373 CLLYEMIAGQSPFQQRKKKIKREEVERL--VKEVPEEYSERFSPQARSLCSQLLCKDPAE 430 +YEM+ G++PF ++ + P ++ S +A+ L +L+C Sbjct: 285 VCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTD-VSEEAKDLIQRLIC-SRER 342 Query: 431 RLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVE 490 RLG G + K+H F+ LN++ + LE P+ PD + D++ ++ E Sbjct: 343 RLGQNG--IEDFKKHAFFEGLNWENI--RNLEAPYIPDVSSPSDTSNFDVDD-DVLRNTE 397 Query: 491 LEPT 494 + P Sbjct: 398 ILPP 401 >3LIJ-A nrPDB Length = 494 Score = 305 bits (781), Expect = 3e-83, Method: Composition-based stats. Identities = 83/296 (28%), Positives = 143/296 (48%), Gaps = 16/296 (5%) Query: 163 DSIYFNRFLQWK----WLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLE 218 +++YF LQ ++ +++ + LG G +GEV C+ + T A K + Sbjct: 12 ENLYFQGDLQATPGMFITSKKGHLSEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIR 71 Query: 219 KKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHM 278 K + + L E +L+ ++ ++ L +E K LV+ GG+L I H Sbjct: 72 KTSV-STSSNSKLLEEVAVLKLLDHPNIMKLYDFFEDKRNYYLVMECYKGGELFDEIIH- 129 Query: 279 GQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDD---HGHIRISDLGLAVH 335 + F E A ++ G+ LH+ IV+RDLKPEN+LL+ I+I D GL+ Sbjct: 130 -RMKFNEVDAAVIIKQVLSGVTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAV 188 Query: 336 VPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKRE 395 + +K R+GT Y+APEV++ ++Y D W++G +L+ ++AG PF + + Sbjct: 189 FENQKKMKERLGTAYYIAPEVLR-KKYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILR 247 Query: 396 EVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 +VE+ + S A+ L Q+L D R+ SA++ EHP K++ Sbjct: 248 KVEKGKYTFDSPEWKNVSEGAKDLIKQMLQFDSQRRI-----SAQQALEHPWIKEM 298 >2JC6-A nrPDB Length = 334 Score = 305 bits (781), Expect = 3e-83, Method: Composition-based stats. Identities = 88/278 (31%), Positives = 136/278 (48%), Gaps = 12/278 (4%) Query: 174 KWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALN 233 W ++ K F LG G F EV + +ATGK++A K + KK +K + E+ N Sbjct: 12 SWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGK--ESSIEN 69 Query: 234 EKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAA 293 E +L K+ +V+L YE+ + L LV+ L++GG+L I G + E A Sbjct: 70 EIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGF--YTEKDASTLIR 127 Query: 294 EICCGLEDLHRERIVYRDLKPENILL---DDHGHIRISDLGLAVHVPEGQTIKGRVGTVG 350 ++ + LHR IV+RDLKPEN+L D+ I ISD GL+ +G + GT G Sbjct: 128 QVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPG 187 Query: 351 YMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE 410 Y+APEV+ + Y+ + D W++G + Y ++ G PF E++ + E Y + Sbjct: 188 YVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWD 247 Query: 411 RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 S A+ L+ KDP +R C + HP Sbjct: 248 DISDSAKDFIRNLMEKDPNKRYTC-----EQAARHPWI 280 >4FG9-A nrPDB Length = 320 Score = 305 bits (781), Expect = 4e-83, Method: Composition-based stats. Identities = 82/278 (29%), Positives = 137/278 (49%), Gaps = 13/278 (4%) Query: 174 KWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALN 233 +W + + + ++ + VLG G F EV + + T K+ A K + K+ ++ ++G N Sbjct: 9 RWKQAEDI-RDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSME--N 65 Query: 234 EKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAA 293 E +L K+ +V+L YE+ L L++ L++GG+L I G + E A Sbjct: 66 EIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGF--YTERDASRLIF 123 Query: 294 EICCGLEDLHRERIVYRDLKPENIL---LDDHGHIRISDLGLAVHVPEGQTIKGRVGTVG 350 ++ ++ LH IV+RDLKPEN+L LD+ I ISD GL+ G + GT G Sbjct: 124 QVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPG 183 Query: 351 YMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE 410 Y+APEV+ + Y+ + D W++G + Y ++ G PF E++ + E Y + Sbjct: 184 YVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWD 243 Query: 411 RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 S A+ L+ KDP +R C + +HP Sbjct: 244 DISDSAKDFIRHLMEKDPEKRFTC-----EQALQHPWI 276 >5DYK-A nrPDB Length = 853 Score = 303 bits (777), Expect = 1e-82, Method: Composition-based stats. Identities = 99/363 (27%), Positives = 166/363 (45%), Gaps = 11/363 (3%) Query: 138 CKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGF 197 + ++ + ++ + F + + ++ V + R++G+G F Sbjct: 493 TASVISKVNNVECWFVDKSVFLQIIQGPMLAHLEERIKMQDTKVEMDELETERIIGRGTF 552 Query: 198 GEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKD 257 G V + T YA K + K+ I + E++I + + F++ L ++ Sbjct: 553 GTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAENDHPFIIRLVRTFKDSK 612 Query: 258 ALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENI 317 + L+ GG+L I +G +++A FY I +E LH IVYRDLKPENI Sbjct: 613 YFYFLTELVTGGELYDAIRKLGL--LSKSQAQFYLGSIILAIEYLHERNIVYRDLKPENI 670 Query: 318 LLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYE 377 LLD G++++ D G A V VGT YMAPEV+ + Y + D WALG LYE Sbjct: 671 LLDKQGYVKLIDFGCAKKVQGRAY--TLVGTPHYMAPEVILGKGYGCTVDIWALGICLYE 728 Query: 378 MIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSP-QARSLCSQLLCKDPAERLGCRG 436 I G PF ++ E+ R + + + + + +L +LLC+ P R+GC Sbjct: 729 FICGPLPFGNDEEDQL--EIFRDILTGQLTFPDYVTDTDSINLMKRLLCRLPQGRIGCSI 786 Query: 437 GSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEPT-- 494 +++K+HP F N+ +L +L+PP Y +D+ DI+Q + E Sbjct: 787 NGFKDIKDHPFFSNFNWDKLAGRLLDPPLVSK-SETYAEDI-DIKQIEEEDAEDDEEPLN 844 Query: 495 DQD 497 D+D Sbjct: 845 DED 847 >4YZB-A nrPDB Length = 491 Score = 303 bits (776), Expect = 1e-82, Method: Composition-based stats. Identities = 85/273 (31%), Positives = 145/273 (53%), Gaps = 11/273 (4%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 + ++ RVLGKG FGEV C+ + TG+ YA K + K+++K++ + + L E ++L+K++ Sbjct: 29 SDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLD 88 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 ++ L +E K LV + GG+L I + F E A ++ G+ + Sbjct: 89 HPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISRKR--FSEVDAARIIRQVLSGITYM 146 Query: 303 HRERIVYRDLKPENILLDD---HGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359 H+ +IV+RDLKPEN+LL++ +IRI D GL+ H + +K ++GT Y+APEV+ Sbjct: 147 HKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAPEVLHG 206 Query: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419 Y D W+ G +LY +++G PF + ++VE+ ++ S A+ L Sbjct: 207 T-YDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDL 265 Query: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 ++L P R+ SAR+ EH K + Sbjct: 266 IRKMLAYVPTMRI-----SARDALEHEWLKTTD 293 >4RGJ-A nrPDB Length = 520 Score = 301 bits (771), Expect = 5e-82, Method: Composition-based stats. Identities = 82/279 (29%), Positives = 139/279 (49%), Gaps = 12/279 (4%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 V ++ ++LGKG FGEV + + TG YA K + KK +K++ + L E ++L+ Sbjct: 57 VFNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKM 116 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 ++ ++ L +E + LV + GG+L I + F E A +I G+ Sbjct: 117 LDHINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKR--FYEIDAARIIKQILSGIT 174 Query: 301 DLHRERIVYRDLKPENILLD----DHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 +H+ +V+RDLKPENILL+ + I+I D GL+ H + +K ++GT Y+AP+V Sbjct: 175 YMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDV 234 Query: 357 VKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQA 416 + Y D W+ G +LY +++G PF + ++VE ++ S +A Sbjct: 235 LHGT-YDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVEAGKYTFDLPQFKKISDKA 293 Query: 417 RSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKR 455 + L ++L A R+ SAR+ EH K + K Sbjct: 294 KDLIKKMLMYTSAVRI-----SARDALEHEWIKMMTSKD 327 >3DFA-A nrPDB Length = 286 Score = 301 bits (770), Expect = 6e-82, Method: Composition-based stats. Identities = 84/295 (28%), Positives = 137/295 (46%), Gaps = 23/295 (7%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI 222 +++YF + +LGKG FGEV C+ R T + YA K + K Sbjct: 12 ENLYFQGTFA-----------ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASA 60 Query: 223 KKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG 282 K K + L E ++L+K++ ++ L E + +V L GG+L I + Sbjct: 61 KN-KDTSTILREVELLKKLDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKR-- 117 Query: 283 FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDD---HGHIRISDLGLAVHVPEG 339 F E A ++ G+ +H+ IV+RDLKPENILL+ I+I D GL+ + Sbjct: 118 FSEHDAARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQN 177 Query: 340 QTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVER 399 +K R+GT Y+APEV++ Y D W+ G +LY +++G PF + + + VE Sbjct: 178 TKMKDRIGTAYYIAPEVLRGT-YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVET 236 Query: 400 LVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFK 454 S A+ L ++L P+ R+ +A + EHP +K + + Sbjct: 237 GKYAFDLPQWRTISDDAKDLIRKMLTFHPSLRI-----TATQCLEHPWIQKYSSE 286 >3NCG-A nrPDB Length = 486 Score = 300 bits (769), Expect = 1e-81, Method: Composition-based stats. Identities = 84/295 (28%), Positives = 137/295 (46%), Gaps = 23/295 (7%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI 222 +++YF + +LGKG FGEV C+ R T + YA K + K Sbjct: 12 ENLYFQGTFA-----------ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASA 60 Query: 223 KKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG 282 K K + L E ++L+K++ ++ L E + +V L GG+L I + Sbjct: 61 KN-KDTSTILREVELLKKLDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKR-- 117 Query: 283 FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDD---HGHIRISDLGLAVHVPEG 339 F E A ++ G+ +H+ IV+RDLKPENILL+ I+I D GL+ + Sbjct: 118 FSEHDAARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQN 177 Query: 340 QTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVER 399 +K R+GT Y+APEV++ Y D W+ G +LY +++G PF + + + VE Sbjct: 178 TKMKDRIGTAYYIAPEVLRGT-YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVET 236 Query: 400 LVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFK 454 S A+ L ++L P+ R+ +A + EHP +K + + Sbjct: 237 GKYAFDLPQWRTISDDAKDLIRKMLTFHPSLRI-----TATQCLEHPWIQKYSSE 286 >5FG8-A nrPDB Length = 285 Score = 299 bits (766), Expect = 2e-81, Method: Composition-based stats. Identities = 79/270 (29%), Positives = 137/270 (50%), Gaps = 12/270 (4%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 + + LGKG F V C ++TG +A K + K++ R + + E +I K++ Sbjct: 13 SDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLE-REARICRKLH 71 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 +V L + + ++ LV L+ GG+L I + + + EA A +I + Sbjct: 72 HPNIVRLHDSIQEENYHYLVFDLVTGGELFEDI--VAREFYSEADASHCIQQILESVNHC 129 Query: 303 HRERIVYRDLKPENILLDDHGH---IRISDLGLAVHV-PEGQTIKGRVGTVGYMAPEVVK 358 H+ +V+RDLKPEN+LL ++++D GLA+ V + Q G GT GY++PEV+K Sbjct: 130 HQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLK 189 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARS 418 E Y S D WA G +LY ++ G PF + +++ + P + +P+A++ Sbjct: 190 KEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKN 249 Query: 419 LCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 L +Q+L +P +R+ +A E +HP Sbjct: 250 LINQMLTVNPNKRI-----TAAEALKHPWI 274 >4AW2-A nrPDB Length = 437 Score = 298 bits (764), Expect = 3e-81, Method: Composition-based stats. Identities = 95/339 (28%), Positives = 168/339 (49%), Gaps = 20/339 (5%) Query: 169 RFLQWKW-----LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIK 223 +L+W +++ + + F +V+G+G FGEV +++ K++A K L K + Sbjct: 54 EYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEML 113 Query: 224 KRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGF 283 KR A E+ +L +S+++ +L YA++ + L LV+ GGDL + + Sbjct: 114 KRAETACFREERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKF-EDRL 172 Query: 284 PEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIK 343 PE A FY AE+ ++ +H+ V+RD+KP+NIL+D +GHIR++D G + + E T++ Sbjct: 173 PEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQ 232 Query: 344 GR--VGTVGYMAPEVVK-----NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREE 396 VGT Y++PE+++ RY DWW+LG +YEM+ G++PF + Sbjct: 233 SSVAVGTPDYISPEILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGK 292 Query: 397 VERLVKEVPEEYS-ERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKR 455 + + S A+ L +L+C RLG G + K+HP F +++ Sbjct: 293 IMNHKERFQFPTQVTDVSENAKDLIRRLIC-SREHRLGQNG--IEDFKKHPFFSGIDWDN 349 Query: 456 LGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEPT 494 + E P+ P+ + D++ +K E P Sbjct: 350 I--RNCEAPYIPEVSSPTDTSNFDVDD-DCLKNSETMPP 385 >5IG1-A nrPDB Length = 344 Score = 298 bits (764), Expect = 4e-81, Method: Composition-based stats. Identities = 74/265 (27%), Positives = 129/265 (48%), Gaps = 11/265 (4%) Query: 187 RQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFV 246 + V+GKG F V C + TG++ A K + K ++ + E I + + Sbjct: 20 DKRSVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINK-IKREIGICSSLQHEHI 78 Query: 247 VSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRER 306 VS+ A+ + LV ++GG+L I + + + E A +I L+ H + Sbjct: 79 VSMRRAFRDESHFYLVFEYVSGGELFDEI--VTRKFYNEKDASACMHQILSALQHCHSKN 136 Query: 307 IVYRDLKPENILL---DDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYT 363 I++RDLKPEN+LL D + ++I+D GLAV + +G T G GT GY++PEV++ Y Sbjct: 137 IIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRRVPYD 196 Query: 364 FSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQL 423 + D WA G +LY ++ G PF + + +++ + P + + A+ L + Sbjct: 197 TAVDVWACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPEWDSVTTAAKELIKAM 256 Query: 424 LCKDPAERLGCRGGSAREVKEHPLF 448 L +P R + +E+ +HP Sbjct: 257 LEPNPKRR-----PTVQELLQHPWI 276 >4OTD-A nrPDB Length = 341 Score = 297 bits (760), Expect = 1e-80, Method: Composition-based stats. Identities = 115/323 (35%), Positives = 169/323 (52%), Gaps = 13/323 (4%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEK 235 L + P+T F+ VLG+G FG+V + R +G+++A K L+K I R + EK Sbjct: 4 LRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEK 63 Query: 236 QILEKV---NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYA 292 +IL V F+V+L ++T + +C V+ GGDL HI+ F E RA+FY+ Sbjct: 64 RILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS---DVFSEPRAIFYS 120 Query: 293 AEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVH-VPEGQTIKGRVGTVGY 351 A + GL+ LH +IVYRDLK +N+LLD G+++I+D GL + G GT + Sbjct: 121 ACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEF 180 Query: 352 MAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSER 411 +APEV+ + YT + DWW LG LLYEM+ G+SPF + EEV + Y Sbjct: 181 LAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDE----EEVFDSIVNDEVRYPRF 236 Query: 412 FSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQA 471 S +A + +LL ++P RLG A +VK+ P F+ L ++ L A L PPF P Sbjct: 237 LSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSG 296 Query: 472 IYCKDVLDIEQFSTVKGVELEPT 494 D + T + L P Sbjct: 297 RTDVSNFD--EEFTGEAPTLSPP 317 >2BDW-A nrPDB Length = 362 Score = 296 bits (759), Expect = 1e-80, Method: Composition-based stats. Identities = 74/269 (27%), Positives = 130/269 (48%), Gaps = 11/269 (4%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 + + LGKG F V C + TG +A K + K++ R + + E +I K+ Sbjct: 28 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLE-REARICRKLQ 86 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 +V L + + + LV L+ GG+L I + + + EA A +I + Sbjct: 87 HPNIVRLHDSIQEESFHYLVFDLVTGGELFEDI--VAREFYSEADASHCIQQILESIAYC 144 Query: 303 HRERIVYRDLKPENILLDDHGH---IRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359 H IV+R+LKPEN+LL ++++D GLA+ V + + G GT GY++PEV+K Sbjct: 145 HSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKK 204 Query: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419 + Y+ D WA G +LY ++ G PF + +++ + P + +P+A+SL Sbjct: 205 DPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSL 264 Query: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLF 448 +L +P +R+ +A + + P Sbjct: 265 IDSMLTVNPKKRI-----TADQALKVPWI 288 >4FR4-A nrPDB Length = 384 Score = 296 bits (758), Expect = 2e-80, Method: Composition-based stats. Identities = 97/312 (31%), Positives = 162/312 (51%), Gaps = 10/312 (3%) Query: 175 WLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNE 234 + E + V + F R +GKG FG+VC Q T KMYA K + K++ +R E Sbjct: 6 FDENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKE 65 Query: 235 KQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAE 294 QI++ + F+V+L Y+++ ++ + +V+ L+ GGDL++H+ F E + E Sbjct: 66 LQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQ--NVHFKEETVKLFICE 123 Query: 295 ICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAP 354 + L+ L +RI++RD+KP+NILLD+HGH+ I+D +A +P I GT YMAP Sbjct: 124 LVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAP 183 Query: 355 EVVKNER---YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSER 411 E+ + + Y+F+ DWW+LG YE++ G+ P+ R +E V V Y Sbjct: 184 EMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTV-VTYPSA 242 Query: 412 FSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQA 471 +S + SL +LL +P +R +V+ P +N+ + L P F P+ Sbjct: 243 WSQEMVSLLKKLLEPNPDQRFSQLS----DVQNFPYMNDINWDAVFQKRLIPGFIPNKGR 298 Query: 472 IYCKDVLDIEQF 483 + C ++E+ Sbjct: 299 LNCDPTFELEEM 310 >2VN9-A nrPDB Length = 301 Score = 296 bits (758), Expect = 2e-80, Method: Composition-based stats. Identities = 77/269 (28%), Positives = 133/269 (49%), Gaps = 12/269 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + ++ + LGKG F V C TG+ YA K + K++ R + + E +I + Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLE-REARICRLLKH 62 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 +V L + + LV L+ GG+L I + + + EA A +I + H Sbjct: 63 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDI--VAREYYSEADASHCIQQILESVNHCH 120 Query: 304 RERIVYRDLKPENILLDDHGH---IRISDLGLAVHV-PEGQTIKGRVGTVGYMAPEVVKN 359 IV+RDLKPEN+LL ++++D GLA+ V + Q G GT GY++PEV++ Sbjct: 121 LNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 180 Query: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419 + Y D WA G +LY ++ G PF + ++++ + P + +P+A+ L Sbjct: 181 DPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDL 240 Query: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLF 448 +++L +PA+R+ +A E +HP Sbjct: 241 INKMLTINPAKRI-----TASEALKHPWI 264 >3KK8-A nrPDB Length = 284 Score = 295 bits (755), Expect = 4e-80, Method: Composition-based stats. Identities = 74/269 (27%), Positives = 130/269 (48%), Gaps = 11/269 (4%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 + + LGKG F V C + TG +A K + K++ R + + E +I K+ Sbjct: 5 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLE-REARICRKLQ 63 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 +V L + + + LV L+ GG+L I + + + EA A +I + Sbjct: 64 HPNIVRLHDSIQEESFHYLVFDLVTGGELFEDI--VAREFYSEADASHCIQQILESIAYC 121 Query: 303 HRERIVYRDLKPENILLDDHGH---IRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359 H IV+R+LKPEN+LL ++++D GLA+ V + + G GT GY++PEV+K Sbjct: 122 HSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKK 181 Query: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419 + Y+ D WA G +LY ++ G PF + +++ + P + +P+A+SL Sbjct: 182 DPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSL 241 Query: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLF 448 +L +P +R+ +A + + P Sbjct: 242 IDSMLTVNPKKRI-----TADQALKVPWI 265 >5U6Y-A nrPDB Length = 461 Score = 294 bits (754), Expect = 4e-80, Method: Composition-based stats. Identities = 74/268 (27%), Positives = 132/268 (49%), Gaps = 12/268 (4%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 ++ + LGKG F V C G+ YA K + K++ R + + E +I + Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLE-REARICRLLKHPN 60 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 +V L + + L+ L+ GG+L I + + + EA A +I + H+ Sbjct: 61 IVRLHDSISEEGHHYLIFDLVTGGELFEDI--VAREYYSEADASHCIQQILEAVLHCHQM 118 Query: 306 RIVYRDLKPENILLDDHGH---IRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKNER 361 +V+RDLKPEN+LL ++++D GLA+ V E Q G GT GY++PEV++ + Sbjct: 119 GVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDP 178 Query: 362 YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCS 421 Y D WA G +LY ++ G PF + ++++ + P + +P+A+ L + Sbjct: 179 YGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLIN 238 Query: 422 QLLCKDPAERLGCRGGSAREVKEHPLFK 449 ++L +P++R+ +A E +HP Sbjct: 239 KMLTINPSKRI-----TAAEALKHPWIS 261 >3Q5I-A nrPDB Length = 504 Score = 294 bits (754), Expect = 5e-80, Method: Composition-based stats. Identities = 79/305 (25%), Positives = 139/305 (45%), Gaps = 24/305 (7%) Query: 163 DSIYFNRFLQWKWL---ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEK 219 +++YF + +++ ++ + R LG G +GEV C+ + A K ++K Sbjct: 12 ENLYFQGIAINPGMYVRKKEGKIGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKK 71 Query: 220 KRIKK----------RKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGG 269 + K K NE +L+ ++ ++ L +E K LV GG Sbjct: 72 SQFDKGRYSDDNKNIEKFHEEIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGG 131 Query: 270 DLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHG---HIR 326 +L I + + F E A +I G+ LH+ IV+RD+KPENILL++ +I+ Sbjct: 132 ELFEQIIN--RHKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIK 189 Query: 327 ISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQ 386 I D GL+ + ++ R+GT Y+APEV+K ++Y D W+ G ++Y ++ G PF Sbjct: 190 IVDFGLSSFFSKDYKLRDRLGTAYYIAPEVLK-KKYNEKCDVWSCGVIMYILLCGYPPFG 248 Query: 387 QRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHP 446 + + ++VE+ + S +A+ L +L D +R +A E Sbjct: 249 GQNDQDIIKKVEKGKYYFDFNDWKNISDEAKELIKLMLTYDYNKR-----CTAEEALNSR 303 Query: 447 LFKKL 451 KK Sbjct: 304 WIKKY 308 >2VZ6-A nrPDB Length = 313 Score = 294 bits (752), Expect = 8e-80, Method: Composition-based stats. Identities = 76/291 (26%), Positives = 137/291 (47%), Gaps = 27/291 (9%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI 222 +++YF ++ + LGKG F V C G+ YA K + K++ Sbjct: 16 ENLYFQSM---------------YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKL 60 Query: 223 KKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG 282 R + + E +I + +V L + + L+ L+ GG+L I + + Sbjct: 61 SARDHQKLE-REARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDI--VAREY 117 Query: 283 FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGH---IRISDLGLAVHVP-E 338 + EA A +I + H+ +V+RDLKPEN+LL ++++D GLA+ V E Sbjct: 118 YSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGE 177 Query: 339 GQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVE 398 Q G GT GY++PEV++ + Y D WA G +LY ++ G PF + ++++ Sbjct: 178 QQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIK 237 Query: 399 RLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFK 449 + P + +P+A+ L +++L +P++R+ +A E +HP Sbjct: 238 AGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRI-----TAAEALKHPWIS 283 >2V7O-A nrPDB Length = 336 Score = 293 bits (750), Expect = 1e-79, Method: Composition-based stats. Identities = 78/289 (26%), Positives = 140/289 (48%), Gaps = 18/289 (6%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI 222 +++YF + ++ + LGKG F V C + + YA K + K++ Sbjct: 16 ENLYFQSMATCTRFT------DDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKL 69 Query: 223 KKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG 282 R + + E +I + +V L + + LV L+ GG+L I + + Sbjct: 70 SARDHQKLE-REARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDI--VAREY 126 Query: 283 FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGH---IRISDLGLAVHV-PE 338 + EA A +I + +H+ IV+RDLKPEN+LL ++++D GLA+ V E Sbjct: 127 YSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGE 186 Query: 339 GQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVE 398 Q G GT GY++PEV++ + Y D WA G +LY ++ G PF + ++++ Sbjct: 187 QQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIK 246 Query: 399 RLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPL 447 + P + +P+A++L +Q+L +PA+R+ +A + +HP Sbjct: 247 AGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRI-----TADQALKHPW 290 >3MN3-A nrPDB Length = 271 Score = 293 bits (750), Expect = 2e-79, Method: Composition-based stats. Identities = 75/266 (28%), Positives = 128/266 (48%), Gaps = 13/266 (4%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 ++ + LG+G FG+V TG+ A K + KK + K + E L + Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHP 64 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 ++ L ++KD + +V+ G +L +I + E A + +I +E HR Sbjct: 65 HIIKLYDVIKSKDEIIMVIEY-AGNELFDYIVQ--RDKMSEQEARRFFQQIISAVEYCHR 121 Query: 305 ERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERY-T 363 +IV+RDLKPEN+LLD+H +++I+D GL+ + +G +K G+ Y APEV+ + Y Sbjct: 122 HKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAG 181 Query: 364 FSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQL 423 D W+ G +LY M+ + PF + + + V +P + SP A L ++ Sbjct: 182 PEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLP----KFLSPGAAGLIKRM 237 Query: 424 LCKDPAERLGCRGGSAREVKEHPLFK 449 L +P R+ S E+ + FK Sbjct: 238 LIVNPLNRI-----SIHEIMQDDWFK 258 >2JAM-A nrPDB Length = 304 Score = 292 bits (747), Expect = 3e-79, Method: Composition-based stats. Identities = 84/297 (28%), Positives = 140/297 (47%), Gaps = 17/297 (5%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 + TF VLG G F EV + R TGK++A K ++K ++ NE +L+K+ Sbjct: 8 RKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKS---PAFRDSSLENEIAVLKKIK 64 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 +V+L YE+ LV+ L++GG+L I G + E A ++ ++ L Sbjct: 65 HENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERG--VYTEKDASLVIQQVLSAVKYL 122 Query: 303 HRERIVYRDLKPENILL---DDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359 H IV+RDLKPEN+L +++ I I+D GL+ + + + GT GY+APEV+ Sbjct: 123 HENGIVHRDLKPENLLYLTPEENSKIMITDFGLSK-MEQNGIMSTACGTPGYVAPEVLAQ 181 Query: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419 + Y+ + D W++G + Y ++ G PF + + E+++ E + + S A+ Sbjct: 182 KPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDF 241 Query: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKD 476 LL KDP ER C + HP ++ + P Q + K Sbjct: 242 ICHLLEKDPNERYTC-----EKALSHPW---IDGNTALHRDIYPSVSLQIQKNFAKS 290 >5KZ7-A nrPDB Length = 346 Score = 292 bits (747), Expect = 3e-79, Method: Composition-based stats. Identities = 80/288 (27%), Positives = 140/288 (48%), Gaps = 14/288 (4%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 + QP N +R + +GKG F +V + TGK A K ++K ++ + + E + Sbjct: 27 DEQPHIGN-YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVR 84 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 I++ +N +V L ET+ L LV+ +GG++ ++ G+ EARA F +I Sbjct: 85 IMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKF--RQIV 142 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 ++ H++ IV+RDLK EN+LLD +I+I+D G + G + G+ Y APE+ Sbjct: 143 SAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPEL 202 Query: 357 VKNERYT-FSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQ 415 + ++Y D W+LG +LY +++G PF + K RE V R +P S Sbjct: 203 FQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTD 258 Query: 416 ARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEP 463 +L + L +P++R G+ ++ + + +EP Sbjct: 259 CENLLKKFLILNPSKR-----GTLEQIMKDRWMNVGHEDDELKPYVEP 301 >4REW-A nrPDB Length = 540 Score = 291 bits (746), Expect = 4e-79, Method: Composition-based stats. Identities = 73/267 (27%), Positives = 126/267 (47%), Gaps = 12/267 (4%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 + LG G FG+V + TG A K L +++I+ E Q L+ Sbjct: 7 HYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHP 66 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 ++ L T + +V+ ++GG+L +I G+ E + +I G++ HR Sbjct: 67 HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGR--LDEKESRRLFQQILSGVDYCHR 124 Query: 305 ERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERY-T 363 +V+RDLKPEN+LLD H + +I+D GL+ + +G+ ++ G+ Y APEV+ Y Sbjct: 125 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 184 Query: 364 FSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQL 423 D W+ G +LY ++ G PF +++ + P + +P SL + Sbjct: 185 PEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTP----QYLNPSVISLLKHM 240 Query: 424 LCKDPAERLGCRGGSAREVKEHPLFKK 450 L DP +R S ++++EH FK+ Sbjct: 241 LQVDPMKR-----ASIKDIREHEWFKQ 262 >4CRS-A nrPDB Length = 341 Score = 291 bits (746), Expect = 4e-79, Method: Composition-based stats. Identities = 116/332 (34%), Positives = 170/332 (51%), Gaps = 22/332 (6%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN- 242 FR VL +G FG+V + + T +M+A K L+K I R + EK+I E VN Sbjct: 12 QDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNS 71 Query: 243 --SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 F+V+L ++TK+ +C V+ GGDL HI+ F E RAVFYAA + GL+ Sbjct: 72 VRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIH---TDVFSEPRAVFYAACVVLGLQ 128 Query: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVH-VPEGQTIKGRVGTVGYMAPEVVKN 359 LH +IVYRDLK +N+LLD G ++I+D GL + G GT ++APEV+ Sbjct: 129 YLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTE 188 Query: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419 YT + DWW LG L+YEM+ G+SPF + EEV + Y S +A S+ Sbjct: 189 TSYTRAVDWWGLGVLIYEMLVGESPFPGDDE----EEVFDSIVNDEVRYPRFLSTEAISI 244 Query: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLD 479 +LL ++P RLG A +VK+HP F+ +++ L ++PPF P + D Sbjct: 245 MRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFD 304 Query: 480 IEQFSTVKGVELEPT---------DQDFYQKF 502 T + L P +Q+ ++ F Sbjct: 305 --DEFTSEAPILTPPREPRILSEEEQEMFRDF 334 >2QNJ-A nrPDB Length = 328 Score = 291 bits (746), Expect = 5e-79, Method: Composition-based stats. Identities = 78/290 (26%), Positives = 141/290 (48%), Gaps = 14/290 (4%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 + QP N +R + +GKG F +V + TG+ A K ++K ++ + + E + Sbjct: 6 DEQPHIGN-YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLF-REVR 63 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 I++ +N +V L ET+ L L++ +GG++ ++ G+ EAR+ F +I Sbjct: 64 IMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKF--RQIV 121 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 ++ H++RIV+RDLK EN+LLD +I+I+D G + G + G+ Y APE+ Sbjct: 122 SAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPEL 181 Query: 357 VKNERYT-FSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQ 415 + ++Y D W+LG +LY +++G PF + K RE V R +P S Sbjct: 182 FQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTD 237 Query: 416 ARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPF 465 +L + L +P +R G+ ++ + + + +EP Sbjct: 238 CENLLKRFLVLNPIKR-----GTLEQIMKDRWINAGHEEDELKPFVEPEL 282 >3BHH-A nrPDB Length = 295 Score = 291 bits (745), Expect = 5e-79, Method: Composition-based stats. Identities = 78/268 (29%), Positives = 134/268 (50%), Gaps = 12/268 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + ++ Y +GKG F V C TG YA K + K++ R + + E +I + Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLE-REARICRLLKH 62 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 +V L + + LV L+ GG+L I + + + EA A +I + H Sbjct: 63 SNIVRLHDSISEEGFHYLVFDLVTGGELFEDI--VAREYYSEADASHCIQQILEAVLHCH 120 Query: 304 RERIVYRDLKPENILLDDHGH---IRISDLGLAVHV-PEGQTIKGRVGTVGYMAPEVVKN 359 + +V+RDLKPEN+LL ++++D GLA+ V + Q G GT GY++PEV++ Sbjct: 121 QMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK 180 Query: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419 E Y D WA G +LY ++ G PF + ++++ + P + +P+A++L Sbjct: 181 EAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNL 240 Query: 420 CSQLLCKDPAERLGCRGGSAREVKEHPL 447 +Q+L +PA+R+ +A E +HP Sbjct: 241 INQMLTINPAKRI-----TAHEALKHPW 263 >5ES1-A nrPDB Length = 328 Score = 291 bits (744), Expect = 7e-79, Method: Composition-based stats. Identities = 79/274 (28%), Positives = 132/274 (48%), Gaps = 14/274 (5%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 E QP N +R R +GKG F +V + TG+ A K ++K ++ + + E + Sbjct: 9 EEQPHVGN-YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLF-REVR 66 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 I++ +N +V L ET+ L LV+ + G++ ++ G+ EARA F +I Sbjct: 67 IMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKF--RQIV 124 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 + H++ IV+RDLK EN+LLD +I+I+D G + G + G+ Y APE+ Sbjct: 125 SAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPEL 184 Query: 357 VKNERYT-FSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQ 415 + ++Y D W+LG +LY +++G PF K RE V R VP S Sbjct: 185 FQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPF----YMSTD 240 Query: 416 ARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFK 449 S+ + L +PA+R + ++ + Sbjct: 241 CESILRRFLVLNPAKR-----CTLEQIMKDKWIN 269 >4RED-A nrPDB Length = 351 Score = 290 bits (742), Expect = 1e-78, Method: Composition-based stats. Identities = 73/267 (27%), Positives = 126/267 (47%), Gaps = 12/267 (4%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 + LG G FG+V + TG A K L +++I+ E Q L+ Sbjct: 15 HYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHP 74 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 ++ L T + +V+ ++GG+L +I G+ E + +I G++ HR Sbjct: 75 HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGR--LDEKESRRLFQQILSGVDYCHR 132 Query: 305 ERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERY-T 363 +V+RDLKPEN+LLD H + +I+D GL+ + +G+ ++ G+ Y APEV+ Y Sbjct: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAG 192 Query: 364 FSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQL 423 D W+ G +LY ++ G PF +++ + P + +P SL + Sbjct: 193 PEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTP----QYLNPSVISLLKHM 248 Query: 424 LCKDPAERLGCRGGSAREVKEHPLFKK 450 L DP +R S ++++EH FK+ Sbjct: 249 LQVDPMKR-----ASIKDIREHEWFKQ 270 >4CFF-A nrPDB Length = 571 Score = 290 bits (742), Expect = 1e-78, Method: Composition-based stats. Identities = 75/285 (26%), Positives = 129/285 (45%), Gaps = 12/285 (4%) Query: 167 FNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRK 226 F + K V + LG G FG+V + + TG A K L +++I+ Sbjct: 16 FQGPMAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLD 75 Query: 227 GEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEA 286 E Q L+ ++ L T +V+ ++GG+L +I G+ E Sbjct: 76 VVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR--VEEM 133 Query: 287 RAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRV 346 A +I ++ HR +V+RDLKPEN+LLD H + +I+D GL+ + +G+ ++ Sbjct: 134 EARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSC 193 Query: 347 GTVGYMAPEVVKNERY-TFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVP 405 G+ Y APEV+ Y D W+ G +LY ++ G PF +++ V +P Sbjct: 194 GSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIP 253 Query: 406 EEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 E + + L +L DP +R + ++++EH FK+ Sbjct: 254 EYLNRSVAT----LLMHMLQVDPLKR-----ATIKDIREHEWFKQ 289 >2VD5-A nrPDB Length = 412 Score = 289 bits (741), Expect = 1e-78, Method: Composition-based stats. Identities = 104/347 (29%), Positives = 167/347 (48%), Gaps = 24/347 (6%) Query: 149 THEYLSVAPFADYLDSIYFNRFLQWK-----WLERQPVTKNTFRQYRVLGKGGFGEVCAC 203 H+ L ++ Y FLQW L+ + ++ F +V+G+G F EV Sbjct: 24 VHQELGA---SELAQDKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVV 80 Query: 204 QVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVL 263 +++ TG++YA K + K + KR + E+ +L + R++ L +A++ ++ L LV+ Sbjct: 81 KMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVM 140 Query: 264 TLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHG 323 GGDL + G+ P A FY AEI ++ +HR V+RD+KP+NILLD G Sbjct: 141 EYYVGGDLLTLLSKFGER-IPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCG 199 Query: 324 HIRISDLGLAVHVPEGQTIKGR--VGTVGYMAPEVVK-------NERYTFSPDWWALGCL 374 HIR++D G + + T++ VGT Y++PE+++ Y DWWALG Sbjct: 200 HIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVF 259 Query: 375 LYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSER-FSPQARSLCSQLLCKDPAERLG 433 YEM GQ+PF ++ + + + +AR +LLC P RLG Sbjct: 260 AYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCP-PETRLG 318 Query: 434 CRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDI 480 G A + + HP F L++ L + PPF PD + D+ Sbjct: 319 RGG--AGDFRTHPFFFGLDWDGLRDSV--PPFTPDFEGATDTCNFDL 361 >4CFH-A nrPDB Length = 493 Score = 289 bits (741), Expect = 2e-78, Method: Composition-based stats. Identities = 75/285 (26%), Positives = 130/285 (45%), Gaps = 12/285 (4%) Query: 167 FNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRK 226 F + K V + LG G FG+V + TG A K L +++I+ Sbjct: 16 FQGPMAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLD 75 Query: 227 GEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEA 286 E Q L+ ++ L T + +V+ ++GG+L +I G+ E Sbjct: 76 VVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGR--LDEK 133 Query: 287 RAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRV 346 + +I G++ HR +V+RDLKPEN+LLD H + +I+D GL+ + +G+ ++ Sbjct: 134 ESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSC 193 Query: 347 GTVGYMAPEVVKNERY-TFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVP 405 G+ Y APEV+ Y D W+ G +LY ++ G PF +++ + P Sbjct: 194 GSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTP 253 Query: 406 EEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 + +P SL +L DP +R + ++++EH FK+ Sbjct: 254 ----QYLNPSVISLLKHMLQVDPMKR-----ATIKDIREHEWFKQ 289 >3H4J-B nrPDB Length = 336 Score = 289 bits (740), Expect = 2e-78, Method: Composition-based stats. Identities = 75/265 (28%), Positives = 129/265 (48%), Gaps = 13/265 (4%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 + LG+G FG+V T + A K + ++ +KK E L+ + Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPH 70 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 ++ L T + +V+ GG+L +I + E + +I C +E HR Sbjct: 71 IIKLYDVITTPTDIVMVIEY-AGGELFDYIVEKKR--MTEDEGRRFFQQIICAIEYCHRH 127 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERY-TF 364 +IV+RDLKPEN+LLDD+ +++I+D GL+ + +G +K G+ Y APEV+ + Y Sbjct: 128 KIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAGP 187 Query: 365 SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLL 424 D W+ G +LY M+ G+ PF ++V V +P + SP A+SL +++ Sbjct: 188 EVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVYVMP----DFLSPGAQSLIRRMI 243 Query: 425 CKDPAERLGCRGGSAREVKEHPLFK 449 DP +R+ + +E++ P F Sbjct: 244 VADPMQRI-----TIQEIRRDPWFN 263 >2J90-A nrPDB Length = 304 Score = 289 bits (739), Expect = 3e-78, Method: Composition-based stats. Identities = 81/296 (27%), Positives = 138/296 (46%), Gaps = 25/296 (8%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI 222 +++YF ++ + + LG G F V C+ + TGK YA K ++K+R+ Sbjct: 16 ENLYFQSMVE-----------DHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRL 64 Query: 223 KKRKG---EAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMG 279 + E IL ++ +++L +E K + L+L L++GG+L + Sbjct: 65 SSSRRGVSREEIEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAE-- 122 Query: 280 QAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDD----HGHIRISDLGLAVH 335 + E A + +I G+ LH +RI + DLKPENI+L D + I++ D G+A Sbjct: 123 KESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHK 182 Query: 336 VPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKRE 395 + G K GT ++APE+V E D W++G + Y +++G SPF K+ Sbjct: 183 IEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLT 242 Query: 396 EVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 + + + EEY S A+ +LL KDP R+ + + EH K + Sbjct: 243 NISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRM-----TIAQSLEHSWIKAI 293 >6E9W-A nrPDB Length = 443 Score = 288 bits (738), Expect = 4e-78, Method: Composition-based stats. Identities = 93/302 (30%), Positives = 145/302 (48%), Gaps = 12/302 (3%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + +V+G+G FGEV + ++T K+YA K L K + KR A E+ I+ NS Sbjct: 102 EDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 161 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 +VV L YA++ L +V+ M GGDL + M PE A FY AE+ L+ +H Sbjct: 162 PWVVQLFYAFQDDRYLYMVMEYMPGGDL---VNLMSNYDVPEKWARFYTAEVVLALDAIH 218 Query: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIK--GRVGTVGYMAPEVVKNER 361 ++RD+KP+N+LLD GH++++D G + + + ++ VGT Y++PEV+K++ Sbjct: 219 SMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQG 278 Query: 362 ----YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 Y DWW++G LYEM+ G +PF ++ + S +A+ Sbjct: 279 GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAK 338 Query: 418 SLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDV 477 +L L D RLG G E+K H FK + P PD + Sbjct: 339 NLICAFLT-DREVRLGRNG--VEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSN 395 Query: 478 LD 479 D Sbjct: 396 FD 397 >6ED6-A nrPDB Length = 415 Score = 288 bits (738), Expect = 4e-78, Method: Composition-based stats. Identities = 94/302 (31%), Positives = 147/302 (48%), Gaps = 12/302 (3%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + +V+G+G FGEV + +A+ K+YA K L K + KR A E+ I+ NS Sbjct: 88 EDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 147 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 +VV L YA++ L +V+ M GGDL + M PE A FY AE+ L+ +H Sbjct: 148 PWVVQLFYAFQDDRYLYMVMEYMPGGDL---VNLMSNYDVPEKWAKFYTAEVVLALDAIH 204 Query: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIK--GRVGTVGYMAPEVVKNER 361 +++RD+KP+N+LLD HGH++++D G + + E + VGT Y++PEV+K++ Sbjct: 205 SMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQG 264 Query: 362 ----YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 Y DWW++G LYEM+ G +PF ++ + S A+ Sbjct: 265 GDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAK 324 Query: 418 SLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDV 477 +L L D RLG G E+++HP FK + P P+ + Sbjct: 325 NLICAFLT-DREVRLGRNG--VEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSN 381 Query: 478 LD 479 D Sbjct: 382 FD 383 >3SOA-A nrPDB Length = 444 Score = 288 bits (737), Expect = 5e-78, Method: Composition-based stats. Identities = 72/270 (26%), Positives = 131/270 (48%), Gaps = 12/270 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 ++ + LGKG F V C G+ YA + K++ R + + E +I + Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLE-REARICRLLKH 69 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 +V L + + L+ L+ GG+L I + + + EA A +I + H Sbjct: 70 PNIVRLHDSISEEGHHYLIFDLVTGGELFEDI--VAREYYSEADASHCIQQILEAVLHCH 127 Query: 304 RERIVYRDLKPENILLDDHGH---IRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKN 359 + +V+R+LKPEN+LL ++++D GLA+ V E Q G GT GY++PEV++ Sbjct: 128 QMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK 187 Query: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419 + Y D WA G +LY ++ G PF + ++++ + P + +P+A+ L Sbjct: 188 DPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDL 247 Query: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLFK 449 +++L +P++R+ +A E +HP Sbjct: 248 INKMLTINPSKRI-----TAAEALKHPWIS 272 >4D28-A nrPDB Length = 446 Score = 287 bits (735), Expect = 7e-78, Method: Composition-based stats. Identities = 80/292 (27%), Positives = 139/292 (47%), Gaps = 14/292 (4%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 + R +G+G F +V + TG A K + K I K + E I++ V Sbjct: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 +V L +K + +VL + GG+L I H G+ E + Y ++ + H Sbjct: 70 NIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGR--LKEDESRKYFQQLVDAVAHCHS 127 Query: 305 ERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEG-QTIKGRVGTVGYMAPEVVKNERYT 363 + + +RDLKPEN+LLD +G++++SD GL+ EG + + GT Y+APEV+ + Y Sbjct: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQGYD 187 Query: 364 FS-PDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQ 422 S D W+ G +L+ ++AG PF + + R + + FS + + L + Sbjct: 188 GSAADIWSCGVILFVILAGYLPFSETD----LPGLYRKINAAEFDCPPWFSAEVKFLIHR 243 Query: 423 LLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYC 474 +L +P R+ +G +K+ P F+K N+ + A E D +A++ Sbjct: 244 ILDPNPKTRIQIQG-----IKKDPWFRK-NYVPIRAREEEEVNLDDIRAVFD 289 >5EZV-A nrPDB Length = 560 Score = 287 bits (735), Expect = 8e-78, Method: Composition-based stats. Identities = 73/272 (26%), Positives = 126/272 (46%), Gaps = 12/272 (4%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 V + LG G FG+V + + TG A K L +++I+ E Q L+ Sbjct: 24 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 83 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 ++ L T +V+ ++GG+L +I G+ E A +I + Sbjct: 84 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQILSAV 141 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359 + HR +V+RDLKPEN+LLD H + +I+D GL+ + +G+ ++ G+ Y APEV+ Sbjct: 142 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 201 Query: 360 ERY-TFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARS 418 Y D W+ G +LY ++ G PF +++ V +PE + + Sbjct: 202 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT---- 257 Query: 419 LCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 L +L DP +R + ++++EH FK+ Sbjct: 258 LLMHMLQVDPLKR-----ATIKDIREHEWFKQ 284 >2YZA-A nrPDB Length = 276 Score = 287 bits (734), Expect = 1e-77, Method: Composition-based stats. Identities = 73/272 (26%), Positives = 126/272 (46%), Gaps = 12/272 (4%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 V + LG G FG+V + + TG A K L +++I+ E Q L+ Sbjct: 7 RVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLK 66 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 ++ L T +V+ ++GG+L +I G+ E A +I + Sbjct: 67 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQILSAV 124 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359 + HR +V+RDLKPEN+LLD H + +I+D GL+ + +G+ ++ G+ Y APEV+ Sbjct: 125 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISG 184 Query: 360 ERY-TFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARS 418 Y D W+ G +LY ++ G PF +++ V +PE + + Sbjct: 185 RLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT---- 240 Query: 419 LCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 L +L DP +R + ++++EH FK+ Sbjct: 241 LLMHMLQVDPLKR-----ATIKDIREHEWFKQ 267 >5YKS-A nrPDB Length = 377 Score = 286 bits (733), Expect = 2e-77, Method: Composition-based stats. Identities = 70/269 (26%), Positives = 128/269 (47%), Gaps = 13/269 (4%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 + + LG+G F V + TG+ A K ++K ++ E + ++ V Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKL-DTLATGHLFQEVRCMKLVQHPN 95 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 +V L +T+ L L+L L +GGD+ +I + G E A Y A+I + H+ Sbjct: 96 IVRLYEVIDTQTKLYLILELGDGGDMFDYIMKH-EEGLNEDLAKKYFAQIVHAISYCHKL 154 Query: 306 RIVYRDLKPEN-ILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYT- 363 +V+RDLKPEN + + G ++++D G + G+ + G++ Y APE++ + Y Sbjct: 155 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDA 214 Query: 364 FSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQL 423 + D W+LG +L+ ++ GQ PFQ+ + VP S + + L +++ Sbjct: 215 PAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVP----SHVSKECKDLITRM 270 Query: 424 LCKDPAERLGCRGGSAREVKEHPLFKKLN 452 L +DP R S E++ HP + ++ Sbjct: 271 LQRDPKRR-----ASLEEIENHPWLQGVD 294 >3ORZ-A nrPDB Length = 316 Score = 286 bits (731), Expect = 3e-77, Method: Composition-based stats. Identities = 93/285 (32%), Positives = 150/285 (52%), Gaps = 12/285 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 F+ ++LG+G F V + AT + YA K LEK+ I K E+ ++ +++ Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 F V L + ++ + L L+ G+L +I +G F E FY AEI LE LH Sbjct: 97 PFFVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIG--SFDETCTRFYTAEIVSALEYLH 154 Query: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT---IKGRVGTVGYMAPEVVKNE 360 + I++RDLKPENILL++ HI+I+D G A + VGT Y++PE++ + Sbjct: 155 GKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEK 214 Query: 361 RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC 420 S D WALGC++Y+++AG PF+ + + +++ +L + PE++ P+AR L Sbjct: 215 SACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFF----PKARDLV 270 Query: 421 SQLLCKDPAERLGCRG-GSAREVKEHPLFKKLNFKRLGAGMLEPP 464 +LL D +RLGC +K HP F+ + ++ L PP Sbjct: 271 EKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ--TPP 313 >5LOH-A nrPDB Length = 341 Score = 284 bits (728), Expect = 5e-77, Method: Composition-based stats. Identities = 91/308 (29%), Positives = 153/308 (49%), Gaps = 19/308 (6%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 +P + F + + +G FG+V Q GK+YA K ++K + + E+ L Sbjct: 31 KPPSIEEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERDAL 88 Query: 239 EKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 S F+V L Y+ ++ + + LV+ + GGD+K ++ G F E AV Y +E+ Sbjct: 89 ALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYG--YFDEEMAVKYISEVALA 146 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAV-------HVPEGQTIKGRVGTVGY 351 L+ LHR I++RDLKP+N+L+ + GHI+++D GL+ ++ + T + GT Y Sbjct: 147 LDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDY 206 Query: 352 MAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSER 411 +APE++ + + DWWALG L+E + G PF + + + + PE E+ Sbjct: 207 LAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGE-EK 265 Query: 412 FSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQA 471 S A+S LL D +R G +E+K HPLF ++++ L + PF P P Sbjct: 266 LSDNAQSAVEILLTIDDTKRAGM-----KELKRHPLFSDVDWENLQHQTM--PFIPQPDD 318 Query: 472 IYCKDVLD 479 + Sbjct: 319 ETDTSYFE 326 >3GUB-A nrPDB Length = 295 Score = 284 bits (728), Expect = 5e-77, Method: Composition-based stats. Identities = 85/294 (28%), Positives = 137/294 (46%), Gaps = 14/294 (4%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKG---EAMALNE 234 RQ + + LG G F V C+ ++TG YA K ++K+R K + E Sbjct: 5 RQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIERE 64 Query: 235 KQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAE 294 IL+++ V++L YE K + L+ L+ GG+L + + E A + + Sbjct: 65 VSILKEIQHPNVITLHEVYENKTDVILIGELVAGGELFDFLAE--KESLTEEEATEFLKQ 122 Query: 295 ICCGLEDLHRERIVYRDLKPENILLDDHG----HIRISDLGLAVHVPEGQTIKGRVGTVG 350 I G+ LH +I + DLKPENI+L D I+I D GLA + G K GT Sbjct: 123 ILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPE 182 Query: 351 YMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE 410 ++APE+V E D W++G + Y +++G SPF K+ V + E +EY Sbjct: 183 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFS 242 Query: 411 RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPP 464 S A+ +LL KDP +R+ + ++ +HP K + ++ + P Sbjct: 243 NTSALAKDFIRRLLVKDPKKRM-----TIQDSLQHPWIKPKDTQQALSSAWSHP 291 >3D2K-A nrPDB Length = 272 Score = 283 bits (725), Expect = 1e-76, Method: Composition-based stats. Identities = 77/268 (28%), Positives = 126/268 (47%), Gaps = 12/268 (4%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 T F R LGKG FG V + R + + A K L K +++K E E +I + Sbjct: 10 TLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHL 69 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 ++ L + + L+L G + + + + F E R Y E+ L Sbjct: 70 RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSR--FDEQRTATYITELANALSY 127 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER 361 H +R+++RD+KPEN+LL +G ++I+D G +VH P + GT+ Y+ PE+++ Sbjct: 128 CHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRR-TTLCGTLDYLPPEMIEGRM 186 Query: 362 YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCS 421 + D W+LG L YE + G PF+ + + R+ P + + AR L S Sbjct: 187 HDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFP----DFVTEGARDLIS 242 Query: 422 QLLCKDPAERLGCRGGSAREVKEHPLFK 449 +LL + ++RL + EV EHP K Sbjct: 243 RLLKHNASQRL-----TLAEVLEHPWIK 265 >4UZD-A nrPDB Length = 287 Score = 282 bits (722), Expect = 2e-76, Method: Composition-based stats. Identities = 75/265 (28%), Positives = 125/265 (47%), Gaps = 12/265 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 F R LGKG FG V + + + + A K L K +++K E E +I + Sbjct: 8 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRH 67 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 ++ L + + L+L G + + + + F E R Y E+ L H Sbjct: 68 PNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSK--FDEQRTATYITELANALSYCH 125 Query: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYT 363 +R+++RD+KPEN+LL G ++I+D G +VH P + GT+ Y+ PE+++ + Sbjct: 126 SKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRR-TTLCGTLDYLPPEMIEGRMHD 184 Query: 364 FSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQL 423 D W+LG L YE + G+ PF+ + + + R+ P + + AR L S+L Sbjct: 185 EKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFP----DFVTEGARDLISRL 240 Query: 424 LCKDPAERLGCRGGSAREVKEHPLF 448 L +P++R REV EHP Sbjct: 241 LKHNPSQR-----PMLREVLEHPWI 260 >3TAC-A nrPDB Length = 361 Score = 282 bits (722), Expect = 3e-76, Method: Composition-based stats. Identities = 82/278 (29%), Positives = 130/278 (46%), Gaps = 14/278 (5%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKG--EAMALNEKQILEK 240 ++ + V+GKG F V C R TG+ +A K ++ + G E I Sbjct: 25 EDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHM 84 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGF--PEARAVFYAAEICCG 298 + +V L Y + L +V M+G DL F I AGF EA A Y +I Sbjct: 85 LKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEA 144 Query: 299 LEDLHRERIVYRDLKPENILL---DDHGHIRISDLGLAVHVPEGQTIKG-RVGTVGYMAP 354 L H I++RD+KP +LL ++ +++ G+A+ + E + G RVGT +MAP Sbjct: 145 LRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAP 204 Query: 355 EVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSP 414 EVVK E Y D W G +L+ +++G PF K+++ E + + ++ S Sbjct: 205 EVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERL-FEGIIKGKYKMNPRQWSHISE 263 Query: 415 QARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 A+ L ++L DPAER+ + E HP K+ + Sbjct: 264 SAKDLVRRMLMLDPAERI-----TVYEALNHPWLKERD 296 >2YAB-A nrPDB Length = 361 Score = 281 bits (720), Expect = 4e-76, Method: Composition-based stats. Identities = 78/290 (26%), Positives = 139/290 (47%), Gaps = 14/290 (4%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKG---EAMALNE 234 +Q ++ + LG G F V C+ ++TG YA K ++K++ + + E Sbjct: 6 KQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIERE 65 Query: 235 KQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAE 294 IL +V +++L YE + + L+L L++GG+L + + E A + + Sbjct: 66 VSILRQVLHPNIITLHDVYENRTDVVLILELVSGGELFDFLAQ--KESLSEEEATSFIKQ 123 Query: 295 ICCGLEDLHRERIVYRDLKPENILLDDHG----HIRISDLGLAVHVPEGQTIKGRVGTVG 350 I G+ LH ++I + DLKPENI+L D HI++ D GLA + +G K GT Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 351 YMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE 410 ++APE+V E D W++G + Y +++G SPF K+ + + + EE+ Sbjct: 184 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFS 243 Query: 411 RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGM 460 + S A+ +LL K+ +RL + +E HP ++ ++ Sbjct: 244 QTSELAKDFIRKLLVKETRKRL-----TIQEALRHPWITPVDTQQAMVRR 288 >2YCR-A nrPDB Length = 323 Score = 281 bits (720), Expect = 5e-76, Method: Composition-based stats. Identities = 78/292 (26%), Positives = 135/292 (46%), Gaps = 20/292 (6%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI-----KKRKGEAMALNEKQI 237 ++ + + LG G GEV R T K A K + K++ ++ E +I Sbjct: 9 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEI 68 Query: 238 LEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 L+K+N ++ + ++ +D +VL LM GG+L + +G EA Y ++ Sbjct: 69 LKKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKV--VGNKRLKEATCKLYFYQMLL 125 Query: 298 GLEDLHRERIVYRDLKPENILL---DDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAP 354 ++ LH I++RDLKPEN+LL ++ I+I+D G + + E ++ GT Y+AP Sbjct: 126 AVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAP 185 Query: 355 EVV---KNERYTFSPDWWALGCLLYEMIAGQSPF-QQRKKKIKREEVERLVKEVPEEYSE 410 EV+ Y + D W+LG +L+ ++G PF + R + ++++ E Sbjct: 186 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 245 Query: 411 RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLE 462 S +A L +LL DP R + E HP + + KR +L Sbjct: 246 EVSEKALDLVKKLLVVDPKARF-----TTEEALRHPWLQDEDMKRKFQDLLS 292 >2W4O-A nrPDB Length = 349 Score = 281 bits (719), Expect = 6e-76, Method: Composition-based stats. Identities = 85/310 (27%), Positives = 134/310 (43%), Gaps = 25/310 (8%) Query: 142 FQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVC 201 FQ ++ +T S AP L Y W + + F LG+G V Sbjct: 20 FQSMSSVTA---SAAPGTASLVPDY------WIDGSNRDALSDFFEVESELGRGATSIVY 70 Query: 202 ACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCL 261 C+ + T K YA K L+K KK + E +L +++ ++ L +ET + L Sbjct: 71 RCKQKGTQKPYALKVLKKTVDKK-----IVRTEIGVLLRLSHPNIIKLKEIFETPTEISL 125 Query: 262 VLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDD 321 VL L+ GG+L I G + E A +I + LH IV+RDLKPEN+L Sbjct: 126 VLELVTGGELFDRIVEKG--YYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYAT 183 Query: 322 ---HGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEM 378 ++I+D GL+ V +K GT GY APE+++ Y D W++G + Y + Sbjct: 184 PAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYIL 243 Query: 379 IAGQSPFQQ-RKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGG 437 + G PF R + + + + S A+ L +L+ DP +RL Sbjct: 244 LCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRL----- 298 Query: 438 SAREVKEHPL 447 + + +HP Sbjct: 299 TTFQALQHPW 308 >4CZT-A nrPDB Length = 464 Score = 281 bits (718), Expect = 7e-76, Method: Composition-based stats. Identities = 76/270 (28%), Positives = 128/270 (47%), Gaps = 15/270 (5%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 + R LG+G F +V + G A K ++K+++ K K A E ++ + Sbjct: 12 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 71 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 V+ + +K + VL + GG+L I G+ E A Y ++ ++ H Sbjct: 72 NVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR--LKEDEARKYFQQLINAVDYCHS 129 Query: 305 ERIVYRDLKPENILLDDHGHIRISDLGLAV---HVPEGQTIKGRVGTVGYMAPEVVKNER 361 + +RDLKPEN+LLD +G +++SD GL+ V E + GT Y+APEV+ N+ Sbjct: 130 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 189 Query: 362 YTF-SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC 420 Y D W+ G +L+ ++AG PF+ +++ + P FS A+ L Sbjct: 190 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPP----WFSASAKKLI 245 Query: 421 SQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 ++L +PA R+ + EV E+ FKK Sbjct: 246 KRILDPNPATRI-----TFAEVIENEWFKK 270 >2BPM-A nrPDB Length = 309 Score = 280 bits (717), Expect = 9e-76, Method: Composition-based stats. Identities = 76/299 (25%), Positives = 133/299 (44%), Gaps = 34/299 (11%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 V F++ +G+G +G V + + TG++ A KK+ + + A+ E +L++ Sbjct: 4 VDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPSTAIREISLLKE 62 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 +N +V L T++ L LV + DLK + G P Y ++ GL Sbjct: 63 LNHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 121 Query: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKN 359 H R+++RDLKP+N+L++ G I+++D GLA +T V T+ Y APE++ Sbjct: 122 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 181 Query: 360 ER-YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFS----- 413 + Y+ + D W+LGC+ EM+ ++ F + + + R + E + Sbjct: 182 CKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY 241 Query: 414 --------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 RSL SQ+L DP +R+ SA+ HP F+ + Sbjct: 242 KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRI-----SAKAALAHPFFQDVT 295 >1ZWS-A nrPDB Length = 288 Score = 280 bits (717), Expect = 1e-75, Method: Composition-based stats. Identities = 79/282 (28%), Positives = 136/282 (48%), Gaps = 14/282 (4%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKG---EAMALNE 234 +Q ++ + LG G F V C+ ++TG YA K ++K++ + + E Sbjct: 6 KQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIERE 65 Query: 235 KQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAE 294 IL +V V++L YE + + L+L L++GG+L + + E A + + Sbjct: 66 VSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQ--KESLSEEEATSFIKQ 123 Query: 295 ICCGLEDLHRERIVYRDLKPENILLDDHG----HIRISDLGLAVHVPEGQTIKGRVGTVG 350 I G+ LH ++I + DLKPENI+L D HI++ D GLA + +G K GT Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 351 YMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE 410 ++APE+V E D W++G + Y +++G SPF K+ + + + EE+ Sbjct: 184 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEEFFS 243 Query: 411 RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 S A+ +LL K+ +RL + +E HP ++ Sbjct: 244 HTSELAKDFIRKLLVKETRKRL-----TIQEALRHPWITPVD 280 >2A27-A nrPDB Length = 321 Score = 279 bits (715), Expect = 2e-75, Method: Composition-based stats. Identities = 79/282 (28%), Positives = 137/282 (48%), Gaps = 14/282 (4%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKG---EAMALNE 234 +Q ++ + LG G F V C+ ++TG YA K ++K++ + + E Sbjct: 6 KQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIERE 65 Query: 235 KQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAE 294 IL +V V++L YE + + L+L L++GG+L + + E A + + Sbjct: 66 VSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQ--KESLSEEEATSFIKQ 123 Query: 295 ICCGLEDLHRERIVYRDLKPENILLDDHG----HIRISDLGLAVHVPEGQTIKGRVGTVG 350 I G+ LH ++I + DLKPENI+L D HI++ D GLA + +G K GT Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 351 YMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE 410 ++APE+V E D W++G + Y +++G SPF K+ + + + EE+ Sbjct: 184 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFS 243 Query: 411 RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 + S A+ +LL K+ +RL + +E HP ++ Sbjct: 244 QTSELAKDFIRKLLVKETRKRL-----TIQEALRHPWITPVD 280 >3COM-A nrPDB Length = 314 Score = 279 bits (715), Expect = 2e-75, Method: Composition-based stats. Identities = 72/285 (25%), Positives = 118/285 (41%), Gaps = 20/285 (7%) Query: 172 QWKWLERQPVTK---NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGE 228 Q K L+ +TK F LG+G +G V + TG++ A K++ Sbjct: 14 QLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPV-----ESDL 68 Query: 229 AMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARA 288 + E I+++ +S VV +Y L +V+ G + I + E Sbjct: 69 QEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSD-IIRLRNKTLTEDEI 127 Query: 289 VFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRV-G 347 GLE LH R ++RD+K NILL+ GH +++D G+A + + + V G Sbjct: 128 ATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIG 187 Query: 348 TVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEE 407 T +MAPEV++ Y D W+LG EM G+ P+ + + P Sbjct: 188 TPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRA---IFMIPTNPPPT 244 Query: 408 Y--SERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 + E +S Q L K P +R +A ++ +HP + Sbjct: 245 FRKPELWSDNFTDFVKQCLVKSPEQR-----ATATQLLQHPFVRS 284 >2Y7J-A nrPDB Length = 365 Score = 279 bits (714), Expect = 2e-75, Method: Composition-based stats. Identities = 86/302 (28%), Positives = 138/302 (45%), Gaps = 22/302 (7%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYR---VLGKGGFGEVCACQVRATGKMYACKKLEK 219 +++YF L K +++Y V+G+G V C RATG +A K +E Sbjct: 70 ENLYFQSMGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEV 129 Query: 220 -----KRIKKRKGEAMALNEKQILEKV-NSRFVVSLAYAYETKDALCLVLTLMNGGDLKF 273 + + E IL +V +++L +YE+ + LV LM G+L Sbjct: 130 TAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFD 189 Query: 274 HIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA 333 ++ + E + + LH IV+RDLKPENILLDD+ IR+SD G + Sbjct: 190 YLTE--KVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFS 247 Query: 334 VHVPEGQTIKGRVGTVGYMAPEVVKNE------RYTFSPDWWALGCLLYEMIAGQSPFQQ 387 H+ G+ ++ GT GY+APE++K Y D WA G +L+ ++AG PF Sbjct: 248 CHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWH 307 Query: 388 RKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPL 447 R++ + + + + S + L S+LL DP RL +A + +HP Sbjct: 308 RRQILMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARL-----TAEQALQHPF 362 Query: 448 FK 449 F+ Sbjct: 363 FE 364 >5XZW-A nrPDB Length = 471 Score = 278 bits (712), Expect = 4e-75, Method: Composition-based stats. Identities = 77/283 (27%), Positives = 127/283 (44%), Gaps = 25/283 (8%) Query: 184 NTFRQY-RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 F V+G+G F V R TGK +A K + K+++ E ++L+K+N Sbjct: 195 KDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVT--RELEVLQKLN 252 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 +V L YE ++ +V+ ++GGDL + G G E + +I ++ + Sbjct: 253 HPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVG--EDAGREISRQILTAIKYI 310 Query: 303 HRERIVYRDLKPENILLDDHGHI--RISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE 360 H I +RDLKP+NIL++ + +I+D GLA G +K GT+ Y+APEV++ + Sbjct: 311 HSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGK 370 Query: 361 -------------RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEE 407 Y+ D W++GCL+Y ++ G PF + +++ R Sbjct: 371 DTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPL 430 Query: 408 YSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 R S +AR LL DP R +A + HP Sbjct: 431 KDFRISEEARDFIDSLLQVDPNNR-----STAAKALNHPWIVD 468 >1PHK-A nrPDB Length = 298 Score = 278 bits (712), Expect = 4e-75, Method: Composition-based stats. Identities = 75/288 (26%), Positives = 126/288 (43%), Gaps = 20/288 (6%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEK------KRIKKRKGEAMALNEKQI 237 + +LG+G V C + T K YA K ++ + ++ L E I Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 238 LEKV-NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 L KV ++ L YET LV LM G+L ++ + E + Sbjct: 77 LRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTE--KVTLSEKETRKIMRALL 134 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 + LH+ IV+RDLKPENILLDD +I+++D G + + G+ ++ GT Y+APE+ Sbjct: 135 EVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPSYLAPEI 194 Query: 357 VKNE------RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE 410 ++ Y D W+ G ++Y ++AG PF RK+ + + + + Sbjct: 195 IECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWD 254 Query: 411 RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGA 458 +S + L S+ L P +R +A E HP F++ + + Sbjct: 255 DYSDTVKDLVSRFLVVQPQKRY-----TAEEALAHPFFQQYVVEEVRH 297 >3I6U-A nrPDB Length = 419 Score = 278 bits (711), Expect = 5e-75, Method: Composition-based stats. Identities = 77/292 (26%), Positives = 135/292 (46%), Gaps = 20/292 (6%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI-----KKRKGEAMALNEKQI 237 ++ + + LG G GEV R T K A + + K++ ++ E +I Sbjct: 134 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEI 193 Query: 238 LEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 L+K+N ++ + ++ +D +VL LM GG+L + +G EA Y ++ Sbjct: 194 LKKLNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKV--VGNKRLKEATCKLYFYQMLL 250 Query: 298 GLEDLHRERIVYRDLKPENILL---DDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAP 354 ++ LH I++RDLKPEN+LL ++ I+I+D G + + E ++ GT Y+AP Sbjct: 251 AVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAP 310 Query: 355 EVV---KNERYTFSPDWWALGCLLYEMIAGQSPF-QQRKKKIKREEVERLVKEVPEEYSE 410 EV+ Y + D W+LG +L+ ++G PF + R + ++++ E Sbjct: 311 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 370 Query: 411 RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLE 462 S +A L +LL DP R + E HP + + KR +L Sbjct: 371 EVSEKALDLVKKLLVVDPKARF-----TTEEALRHPWLQDEDMKRKFQDLLS 417 >3F3Z-A nrPDB Length = 277 Score = 278 bits (711), Expect = 5e-75, Method: Composition-based stats. Identities = 69/270 (25%), Positives = 124/270 (45%), Gaps = 14/270 (5%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + +G+G +GEV + T A KK+ K ++ E +I++ ++ Sbjct: 9 QYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVE---DVDRFKQEIEIMKSLDH 65 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 ++ L +E + LV+ L GG+L + H + F E+ A ++ + H Sbjct: 66 PNIIRLYETFEDNTDIYLVMELCTGGELFERVVH--KRVFRESDAARIMKDVLSAVAYCH 123 Query: 304 RERIVYRDLKPENILL---DDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE 360 + + +RDLKPEN L +++ D GLA G+ ++ +VGT Y++P+V++ Sbjct: 124 KLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVSPQVLEG- 182 Query: 361 RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC 420 Y D W+ G ++Y ++ G PF ++ PE+ SPQA SL Sbjct: 183 LYGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWLNVSPQAESLI 242 Query: 421 SQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 +LL K P +R+ ++ + EH F+K Sbjct: 243 RRLLTKSPKQRI-----TSLQALEHEWFEK 267 >4C0T-A nrPDB Length = 974 Score = 278 bits (710), Expect = 7e-75, Method: Composition-based stats. Identities = 90/321 (28%), Positives = 157/321 (48%), Gaps = 24/321 (7%) Query: 177 ERQPVTKN--TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNE 234 E + + +N F+ + LG+G + V + TGK YA K L+K+ I K K E Sbjct: 257 EMKTIRRNVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIE 316 Query: 235 KQILEKVNSRF-VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAA 293 K L ++++R V+SL + ++ KD+L VL + G+L I E + A Sbjct: 317 KHALNRLSNRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYN--TLNEECTRHFGA 374 Query: 294 EICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAV----------HVPEGQTIK 343 +I ++ +H +++RDLKPENILLDD I+I+D G A P K Sbjct: 375 QILDAIKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAK 434 Query: 344 GRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKE 403 VGT Y++PE+++N+ D WA GC++Y+MIAG+ PF+ + + +++ +L Sbjct: 435 SFVGTAEYVSPELLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQFA 494 Query: 404 VPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEP 463 + R L ++L P+ R + E+++H F+ ++FK + L Sbjct: 495 FSAGFPTII----RDLIKKILVLQPSRR-----ATIPEIQKHYFFQSVDFKDFDSIWLSD 545 Query: 464 PFKPDPQAIYCKDVLDIEQFS 484 P + P + K ++ + + + Sbjct: 546 PPEIGPYKMTAKSMMKVPELN 566 >4JXF-A nrPDB Length = 266 Score = 277 bits (709), Expect = 9e-75, Method: Composition-based stats. Identities = 74/267 (27%), Positives = 125/267 (46%), Gaps = 11/267 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 F+ +LGKG F V + TG A K ++KK + K NE +I ++ Sbjct: 7 EDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKH 66 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 ++ L +E + + LVL + + G++ ++ + + F E A + +I G+ LH Sbjct: 67 PSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKP-FSENEARHFMHQIITGMLYLH 125 Query: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKNERY 362 I++RDL N+LL + +I+I+D GLA + + GT Y++PE+ + Sbjct: 126 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH 185 Query: 363 TFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQ 422 D W+LGC+ Y ++ G+ PF K +V E+P S +A+ L Q Sbjct: 186 GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMP----SFLSIEAKDLIHQ 241 Query: 423 LLCKDPAERLGCRGGSAREVKEHPLFK 449 LL ++PA+RL V +HP Sbjct: 242 LLRRNPADRLSLSS-----VLDHPFMS 263 >5JZN-A nrPDB Length = 280 Score = 274 bits (701), Expect = 8e-74, Method: Composition-based stats. Identities = 79/273 (28%), Positives = 126/273 (46%), Gaps = 17/273 (6%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 ++ R +G G F V C R+T + YA K ++K + R E M NE IL +V Sbjct: 19 ERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKC--RGKEHMIQNEVSILRRVKH 76 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 +V L + L LV+ L+ GGDL I + + E A + ++ LH Sbjct: 77 PNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNK--YTERDASGMLYNLASAIKYLH 134 Query: 304 RERIVYRDLKPENILLDDH----GHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359 IV+RD+KPEN+L+ +H +++ D GLA V + GT Y+APE++ Sbjct: 135 SLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV--DGPLYTVCGTPTYVAPEIIAE 192 Query: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQ--QRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 Y D WA G + Y ++ G PF+ +++ +++ + P Y + S A+ Sbjct: 193 TGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAK 252 Query: 418 SLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 L + +L D +R SA +V EHP Sbjct: 253 ELITMMLLVDVDQRF-----SAVQVLEHPWVND 280 >4LG4-A nrPDB Length = 299 Score = 274 bits (700), Expect = 1e-73, Method: Composition-based stats. Identities = 65/272 (23%), Positives = 114/272 (41%), Gaps = 17/272 (6%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 + F LG+G +G V + +G++ A K++ + E I+++ Sbjct: 9 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV-----ESDLQEIIKEISIMQQC 63 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 +S +VV +Y L +V+ G + I + E GLE Sbjct: 64 DSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSD-IIRLRNKTLIEDEIATILKSTLKGLEY 122 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRV-GTVGYMAPEVVKNE 360 LH R ++R++K NILL+ GH +++D G+A + + + V GT +MAPEV++ Sbjct: 123 LHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEI 182 Query: 361 RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEY--SERFSPQARS 418 Y D W+LG EM G+ P+ + + P + E +S Sbjct: 183 GYNCVADIWSLGITSIEMAEGKPPYADIHPMRA---IFMIPTNPPPTFRKPELWSDDFTD 239 Query: 419 LCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 + L K+P +R +A ++ +HP K Sbjct: 240 FVKKCLVKNPEQR-----ATATQLLQHPFIKN 266 >1KOB-A nrPDB Length = 387 Score = 273 bits (697), Expect = 2e-73, Method: Composition-based stats. Identities = 85/298 (28%), Positives = 139/298 (46%), Gaps = 19/298 (6%) Query: 167 FNRFLQ--WKWLERQPV------TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLE 218 +++F + WK QPV + + LG G FG V C +ATG+++ K + Sbjct: 26 YDKFYEDIWKKYVPQPVEVKQGSVYDYYDILEELGSGAFGVVHRCVEKATGRVFVAKFIN 85 Query: 219 KKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHM 278 + NE I+ +++ +++L A+E K + L+L ++GG+L I Sbjct: 86 TPYPLDK---YTVKNEISIMNQLHHPKLINLHDAFEDKYEMVLILEFLSGGELFDRI-AA 141 Query: 279 GQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDH--GHIRISDLGLAVHV 336 EA + Y + C GL+ +H IV+ D+KPENI+ + ++I D GLA + Sbjct: 142 EDYKMSEAEVINYMRQACEGLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKL 201 Query: 337 PEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREE 396 + +K T + APE+V E F D WA+G L Y +++G SPF + Sbjct: 202 NPDEIVKVTTATAEFAAPEIVDREPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQN 261 Query: 397 VERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFK 454 V+R E E+ SP+A+ LL K+P +RL + + EHP K + Sbjct: 262 VKRCDWEFDEDAFSSVSPEAKDFIKNLLQKEPRKRL-----TVHDALEHPWLKGDHSN 314 >5WAX-A nrPDB Length = 310 Score = 273 bits (697), Expect = 2e-73, Method: Composition-based stats. Identities = 74/295 (25%), Positives = 124/295 (42%), Gaps = 21/295 (7%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 + + R +G G FG + RA G++ A K +E+ K + E + Sbjct: 10 GDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERG----EKIDENVQREIINHRSLR 65 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 ++ T L +V+ +GG+L I + G+ F E A F+ ++ G+ Sbjct: 66 HPNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSYC 123 Query: 303 HRERIVYRDLKPENILLDDHG--HIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE 360 H ++ +RDLK EN LLD ++I D G + K VGT Y+APEV+ + Sbjct: 124 HSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKK 183 Query: 361 RYTFSP-DWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE--RFSPQAR 417 Y D W+ G LY M+ G PF+ + + + + V + SP+ + Sbjct: 184 EYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHISPECQ 243 Query: 418 SLCSQLLCKDPAERLGCRGGSAREVKEHPLF-----KKLNFKRLGAGMLEPPFKP 467 L S++ +PA R+ + E++ HP F L + E P +P Sbjct: 244 DLISRIFVANPATRI-----TIPEIRNHPWFLKNLPADLMDDSTMSKQYEEPEQP 293 >2HAK-A nrPDB Length = 328 Score = 272 bits (696), Expect = 3e-73, Method: Composition-based stats. Identities = 84/294 (28%), Positives = 144/294 (48%), Gaps = 18/294 (6%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 + QP N +R + +GKG F +V + TG+ A K ++K ++ + + E + Sbjct: 9 DEQPHIGN-YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLF-REVR 66 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 I++ +N +V L ET+ L LV+ +GG++ ++ G+ EARA F +I Sbjct: 67 IMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKF--RQIV 124 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 ++ H++ IV+RDLK EN+LLD +I+I+D G + G + G+ Y APE+ Sbjct: 125 SAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPEL 184 Query: 357 VKNERYT-FSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQ 415 + ++Y D W+LG +LY +++G PF + K RE V R +P S Sbjct: 185 FQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTD 240 Query: 416 ARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDP 469 +L +LL +P +R GS ++ + + L+P +PDP Sbjct: 241 CENLLKKLLVLNPIKR-----GSLEQIMKDRWMNVGH----EEEELKPYTEPDP 285 >5J5T-A nrPDB Length = 370 Score = 271 bits (693), Expect = 5e-73, Method: Composition-based stats. Identities = 72/310 (23%), Positives = 136/310 (43%), Gaps = 15/310 (4%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 ++ F + +G G +G+V + TG++ A K ++ ++ + A+ E +++ Sbjct: 2 SQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIK---LEPGEDFAVVQQEIIMMKDC 58 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 +V+ +Y +D L + + GG L+ IYH+ E + + + E GL Sbjct: 59 KHPNIVAYFGSYLRRDKLWICMEFCGGGSLQD-IYHVTGP-LSELQIAYVSRETLQGLYY 116 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEG-QTIKGRVGTVGYMAPEVV--- 357 LH + ++RD+K NILL D+GH++++D G++ + K +GT +MAPEV Sbjct: 117 LHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVE 176 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE-RFSPQA 416 + Y D WA+G E+ Q P + + + P+ + ++S Sbjct: 177 RKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSF 236 Query: 417 RSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKD 476 L K+P +R +A ++ +HP + + L +L+ PD + D Sbjct: 237 HHFVKMALTKNPKKR-----PTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFD 291 Query: 477 VLDIEQFSTV 486 D E V Sbjct: 292 DDDPEPLVAV 301 >6BXI-A nrPDB Length = 333 Score = 271 bits (693), Expect = 6e-73, Method: Composition-based stats. Identities = 85/338 (25%), Positives = 148/338 (43%), Gaps = 48/338 (14%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 F +V+G+G FGEV Q + TG +YA K L K + +++ E+ IL + +S Sbjct: 6 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADS 65 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 +VV + Y+++ K L L++ + GGD+ + M + E FY AE ++ +H Sbjct: 66 LWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLL--MKKDTLTEEETQFYIAETVLAIDSIH 123 Query: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIK-------------------- 343 + ++RD+KP+N+LLD GH+++SD GL + + + Sbjct: 124 QLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNS 183 Query: 344 ----------------GRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQ 387 VGT Y+APEV Y DWW+LG ++YEM+ G PF Sbjct: 184 KRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCS 243 Query: 388 RKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPL 447 + ++V + + S +A+ L + C + R+G E+K + Sbjct: 244 ETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCC-EWEHRIGA--PGVEEIKSNSF 300 Query: 448 FKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFST 485 F+ ++++ + P +I K + D F Sbjct: 301 FEGVDWEHIRER-------PAAISIEIKSIDDTSNFDE 331 >4PDS-A nrPDB Length = 347 Score = 271 bits (693), Expect = 6e-73, Method: Composition-based stats. Identities = 76/283 (26%), Positives = 127/283 (44%), Gaps = 25/283 (8%) Query: 184 NTFRQY-RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 F V+G+G F V R TGK ++ K + K+++ E ++L+K+N Sbjct: 30 KDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVT--RELEVLQKLN 87 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 +V L YE ++ +V+ ++GGDL + G G E + +I ++ + Sbjct: 88 HPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVG--EDAGREISRQILTAIKYI 145 Query: 303 HRERIVYRDLKPENILLDDHGHI--RISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE 360 H I +RDLKP+NIL++ + +I+ GLA G +K GT+ Y+APEV++ + Sbjct: 146 HSMGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGK 205 Query: 361 -------------RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEE 407 Y+ D W++GCL+Y ++ G PF + +++ R Sbjct: 206 DTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPL 265 Query: 408 YSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 R S +AR LL DP R +A + HP K Sbjct: 266 KDFRISEEARDFIDSLLQVDPNNR-----STAAKALNHPWIKM 303 >2X4F-A nrPDB Length = 373 Score = 271 bits (692), Expect = 8e-73, Method: Composition-based stats. Identities = 77/275 (28%), Positives = 137/275 (49%), Gaps = 13/275 (4%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 +LG G FG+V C+ ATG A K ++ + +K ++ NE ++ +++ ++ L Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVK---NEISVMNQLDHANLIQL 151 Query: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 A+E+K+ + LV+ ++GG+L I E + + +IC G+ +H+ I++ Sbjct: 152 YDAFESKNDIVLVMEYVDGGELFDRIIDESYN-LTELDTILFMKQICEGIRHMHQMYILH 210 Query: 310 RDLKPENILLDDH--GHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPD 367 DLKPENIL + I+I D GLA + +K GT ++APEVV + +F D Sbjct: 211 LDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTD 270 Query: 368 WWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKD 427 W++G + Y +++G SPF + ++ +E + S +A+ S+LL K+ Sbjct: 271 MWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKE 330 Query: 428 PAERLGCRGGSAREVKEHPLFK--KLNFKRLGAGM 460 + R+ SA E +HP KL+ + Sbjct: 331 KSWRI-----SASEALKHPWLSDHKLHSRLSAQKK 360 >3NIZ-A nrPDB Length = 311 Score = 270 bits (690), Expect = 1e-72, Method: Composition-based stats. Identities = 73/318 (22%), Positives = 143/318 (44%), Gaps = 49/318 (15%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI 222 +++YF + +++ +G+G +G V + + G++ A K++ Sbjct: 12 ENLYFQGLM------------EKYQKLEKVGEGTYGVVYKAKD-SQGRIVALKRIRLDA- 57 Query: 223 KKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG 282 + + A+ E +L++++ +VSL ++ L LV M DLK + + G Sbjct: 58 EDEGIPSTAIREISLLKELHHPNIVSLIDVIHSERCLTLVFEFMEK-DLKKVLDE-NKTG 115 Query: 283 FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVP-EGQT 341 +++ Y ++ G+ H+ RI++RDLKP+N+L++ G ++++D GLA ++ Sbjct: 116 LQDSQIKIYLYQLLRGVAHCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRS 175 Query: 342 IKGRVGTVGYMAPEVVKN-ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERL 400 V T+ Y AP+V+ ++Y+ S D W++GC+ EMI G+ F + ++ + Sbjct: 176 YTHEVVTLWYRAPDVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSI 235 Query: 401 VKEVPEEYSER--------------------------FSPQARSLCSQLLCKDPAERLGC 434 + + F + L S +LC DP +R+ Sbjct: 236 LGTPNPREWPQVQELPLWKQRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRI-- 293 Query: 435 RGGSAREVKEHPLFKKLN 452 SAR+ HP FK L+ Sbjct: 294 ---SARDAMNHPYFKDLD 308 >3UTO-A nrPDB Length = 573 Score = 269 bits (688), Expect = 2e-72, Method: Composition-based stats. Identities = 75/287 (26%), Positives = 121/287 (42%), Gaps = 17/287 (5%) Query: 170 FLQWKWLERQPVTK------NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIK 223 F WK QPV + + + LG G FG V RATG +A K + Sbjct: 137 FDIWKQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFV---MTP 193 Query: 224 KRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGF 283 + E Q + + +V+L A+E + + ++ M+GG+L + Sbjct: 194 HESDKETVRKEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNK-M 252 Query: 284 PEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDD--HGHIRISDLGLAVHVPEGQT 341 E AV Y ++C GL +H V+ DLKPENI+ +++ D GL H+ Q+ Sbjct: 253 SEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQS 312 Query: 342 IKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLV 401 +K GT + APEV + + + D W++G L Y +++G SPF V+ Sbjct: 313 VKVTTGTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCD 372 Query: 402 KEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 + + S + +LL DP R+ + + EHP Sbjct: 373 WNMDDSAFSGISEDGKDFIRKLLLADPNTRM-----TIHQALEHPWL 414 >6AO5-A nrPDB Length = 362 Score = 269 bits (687), Expect = 3e-72, Method: Composition-based stats. Identities = 65/272 (23%), Positives = 114/272 (41%), Gaps = 17/272 (6%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 + F LG+G +G V + +G++ A K++ + E I+++ Sbjct: 8 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV-----ESDLQEIIKEISIMQQC 62 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 +S +VV +Y L +V+ G + I + E GLE Sbjct: 63 DSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSD-IIRLRNKTLIEDEIATILKSTLKGLEY 121 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRV-GTVGYMAPEVVKNE 360 LH R ++R++K NILL+ GH +++D G+A + + + V GT +MAPEV++ Sbjct: 122 LHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEI 181 Query: 361 RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEY--SERFSPQARS 418 Y D W+LG EM G+ P+ + + P + E +S Sbjct: 182 GYNCVADIWSLGITSIEMAEGKPPYADIHPMRA---IFMIPTNPPPTFRKPELWSDDFTD 238 Query: 419 LCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 + L K+P +R +A ++ +HP K Sbjct: 239 FVKKCLVKNPEQR-----ATATQLLQHPFIKN 265 >6FD3-A nrPDB Length = 300 Score = 269 bits (687), Expect = 3e-72, Method: Composition-based stats. Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 13/269 (4%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 K + ++ +G+G G V ATG+ A K++ ++++ + + +NE ++ + Sbjct: 20 PKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN---LQQQPKKELIINEILVMREN 76 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 + +V+ +Y D L +V+ + GG L + E + E L+ Sbjct: 77 KNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC---MDEGQIAAVCRECLQALDF 133 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV-PEGQTIKGRVGTVGYMAPEVVKNE 360 LH ++++RD+K +NILL G ++++D G + PE VGT +MAPEVV + Sbjct: 134 LHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRK 193 Query: 361 RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC 420 Y D W+LG + EM+ G+ P+ + + ER S R Sbjct: 194 AYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIAT-NGTPELQNPERLSAVFRDFL 252 Query: 421 SQLLCKDPAERLGCRGGSAREVKEHPLFK 449 ++ L D R GSA+E+ +HP K Sbjct: 253 NRCLEMDVDRR-----GSAKELLQHPFLK 276 >6C9D-A nrPDB Length = 459 Score = 269 bits (687), Expect = 3e-72, Method: Composition-based stats. Identities = 84/294 (28%), Positives = 144/294 (48%), Gaps = 18/294 (6%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 + QP N +R + +GKG F +V + TG+ A K ++K ++ + + E + Sbjct: 15 DEQPHIGN-YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLF-REVR 72 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 I++ +N +V L ET+ L LV+ +GG++ ++ G+ EARA F +I Sbjct: 73 IMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKF--RQIV 130 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 ++ H++ IV+RDLK EN+LLD +I+I+D G + G + G+ Y APE+ Sbjct: 131 SAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPEL 190 Query: 357 VKNERYT-FSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQ 415 + ++Y D W+LG +LY +++G PF + K RE V R +P S Sbjct: 191 FQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTD 246 Query: 416 ARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDP 469 +L +LL +P +R GS ++ + + L+P +PDP Sbjct: 247 CENLLKKLLVLNPIKR-----GSLEQIMKDRWMNVGH----EEEELKPYTEPDP 291 >4NIF-A nrPDB Length = 333 Score = 268 bits (685), Expect = 5e-72, Method: Composition-based stats. Identities = 84/292 (28%), Positives = 131/292 (44%), Gaps = 25/292 (8%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL-E 239 V + + +G G + E C +AT YA K ++K + + E +IL Sbjct: 5 VFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE-------EIEILLR 57 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 +++L Y+ + LV LM GG+L I Q F E A F I + Sbjct: 58 YGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILR--QKFFSEREASFVLHTIGKTV 115 Query: 300 EDLHRERIVYRDLKPENIL-LDDHGH---IRISDLGLAVHV-PEGQTIKGRVGTVGYMAP 354 E LH + +V+RDLKP NIL +D+ G+ +RI D G A + E + T ++AP Sbjct: 116 EYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAP 175 Query: 355 EVVKNERYTFSPDWWALGCLLYEMIAGQSPF---QQRKKKIKREEVERLVKEVPEEYSER 411 EV+K + Y D W+LG LLY M+AG +PF + + + Sbjct: 176 EVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNT 235 Query: 412 FSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEP 463 S A+ L S++L DP +RL +A++V +HP + + +L L Sbjct: 236 VSETAKDLVSKMLHVDPHQRL-----TAKQVLQHPWVTQKD--KLPQSQLSH 280 >1KOA-A nrPDB Length = 491 Score = 267 bits (682), Expect = 1e-71, Method: Composition-based stats. Identities = 75/287 (26%), Positives = 121/287 (42%), Gaps = 17/287 (5%) Query: 170 FLQWKWLERQPVTK------NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIK 223 F WK QPV + + + LG G FG V RATG +A K + Sbjct: 31 FDIWKQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFV---MTP 87 Query: 224 KRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGF 283 + E Q + + +V+L A+E + + ++ M+GG+L + Sbjct: 88 HESDKETVRKEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNK-M 146 Query: 284 PEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDD--HGHIRISDLGLAVHVPEGQT 341 E AV Y ++C GL +H V+ DLKPENI+ +++ D GL H+ Q+ Sbjct: 147 SEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQS 206 Query: 342 IKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLV 401 +K GT + APEV + + + D W++G L Y +++G SPF V+ Sbjct: 207 VKVTTGTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCD 266 Query: 402 KEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 + + S + +LL DP R+ + + EHP Sbjct: 267 WNMDDSAFSGISEDGKDFIRKLLLADPNTRM-----TIHQALEHPWL 308 >2F57-A nrPDB Length = 317 Score = 266 bits (681), Expect = 1e-71, Method: Composition-based stats. Identities = 82/311 (26%), Positives = 138/311 (44%), Gaps = 33/311 (10%) Query: 142 FQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVC 201 FQ ++R++HE A LQ P + + +G+G G VC Sbjct: 19 FQSMSRVSHEQFRAA--------------LQLVVSPGDP--REYLANFIKIGEGSTGIVC 62 Query: 202 ACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCL 261 + TGK A KK++ ++K++ + NE I+ + VV + +Y D L + Sbjct: 63 IATEKHTGKQVAVKKMD---LRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWV 119 Query: 262 VLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDD 321 V+ + GG L + H E + + L LH + +++RD+K ++ILL Sbjct: 120 VMEFLEGGALTDIVTHT---RMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTS 176 Query: 322 HGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA 380 G I++SD G V E K VGT +MAPEV+ Y D W+LG ++ EMI Sbjct: 177 DGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMID 236 Query: 381 GQSPFQQRKKKIKREEVERLVKEVPEEYSE--RFSPQARSLCSQLLCKDPAERLGCRGGS 438 G+ P+ + + R+ +P + + S R +L ++P++R + Sbjct: 237 GEPPYFNEPP---LQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQR-----AT 288 Query: 439 AREVKEHPLFK 449 A+E+ HP K Sbjct: 289 AQELLGHPFLK 299 >2UV2-A nrPDB Length = 325 Score = 266 bits (680), Expect = 2e-71, Method: Composition-based stats. Identities = 67/292 (22%), Positives = 124/292 (42%), Gaps = 18/292 (6%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI 222 +++YF Q++ + R ++ + LG G FG+V Q + T + A K ++ Sbjct: 16 ENLYFQSMKQYEHVTRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVID---T 72 Query: 223 KKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG 282 K + + E IL + +V L A+ ++ L +++ GG + + + + Sbjct: 73 KSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERP- 131 Query: 283 FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEG-QT 341 E++ + L LH +I++RDLK NIL G I+++D G++ Q Sbjct: 132 LTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQR 191 Query: 342 IKGRVGTVGYMAPEVVK-----NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREE 396 +GT +MAPEVV + Y + D W+LG L EM + P + + Sbjct: 192 RDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLK 251 Query: 397 VERLVKEVPEEY-SERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPL 447 + + E P R+S + + L K+ R + ++ +HP Sbjct: 252 IAK--SEPPTLAQPSRWSSNFKDFLKKCLEKNVDAR-----WTTSQLLQHPF 296 >4JG6-A nrPDB Length = 355 Score = 266 bits (680), Expect = 2e-71, Method: Composition-based stats. Identities = 83/319 (26%), Positives = 135/319 (42%), Gaps = 27/319 (8%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL-EKVN 242 + + +G G + C +AT +A K ++K + + E +IL Sbjct: 35 DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE-------EIEILLRYGQ 87 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 +++L Y+ + +V LM GG+L I Q F E A I +E L Sbjct: 88 HPNIITLKDVYDDGKYVYVVTELMKGGELLDKILR--QKFFSEREASAVLFTITKTVEYL 145 Query: 303 HRERIVYRDLKPENIL-LDDHGH---IRISDLGLAVHV-PEGQTIKGRVGTVGYMAPEVV 357 H + +V+RDLKP NIL +D+ G+ IRI D G A + E + T ++APEV+ Sbjct: 146 HAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVL 205 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSPF---QQRKKKIKREEVERLVKEVPEEYSERFSP 414 + + Y + D W+LG LLY M+ G +PF + + + Y S Sbjct: 206 ERQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSD 265 Query: 415 QARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYC 474 A+ L S++L DP +RL +A V HP +++ +L L + P + Sbjct: 266 TAKDLVSKMLHVDPHQRL-----TAALVLRHPWI--VHWDQLPQYQLNR--QDAPHLVKG 316 Query: 475 KDVLDIEQFSTVKGVELEP 493 + + LEP Sbjct: 317 AMAATYSALNRNQSPVLEP 335 >6GU6-A nrPDB Length = 302 Score = 266 bits (680), Expect = 2e-71, Method: Composition-based stats. Identities = 67/299 (22%), Positives = 126/299 (42%), Gaps = 35/299 (11%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 + + + +G+G +G V + + TG++ A KK+ + ++ + A+ E +L+++ Sbjct: 5 SMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEEGVPSTAIREISLLKEL 63 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQ-AGFPEARAVFYAAEICCGLE 300 +VSL L L+ ++ DLK ++ + + Y +I G+ Sbjct: 64 RHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 122 Query: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKN 359 H R+++RDLKP+N+L+DD G I+++D GLA + V T+ Y +PEV+ Sbjct: 123 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 182 Query: 360 E-RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERF------ 412 RY+ D W++G + E+ + F + + + R + E Sbjct: 183 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 242 Query: 413 -------------------SPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 L S++L DPA+R+ S + HP F L+ Sbjct: 243 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI-----SGKMALNHPYFNDLD 296 >4CQG-A nrPDB Length = 331 Score = 266 bits (679), Expect = 2e-71, Method: Composition-based stats. Identities = 70/275 (25%), Positives = 122/275 (44%), Gaps = 16/275 (5%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEK 235 ++ + Y +G GGF +V TG+M A K ++K + E Sbjct: 1 MKDYDELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLP--RVKTEI 58 Query: 236 QILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEI 295 L+ + + + L + ETK+ + +VL GG+L +I + E +I Sbjct: 59 DALKSLRHQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDR--LSEEETRVVFRQI 116 Query: 296 CCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR--VGTVGYMA 353 + +H + +RDLKPEN+L D++ +++ D GL + + G++ Y A Sbjct: 117 LSAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAA 176 Query: 354 PEVVKNERY-TFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERF 412 PE+++ + Y D W++G LLY ++ G PF +++ R EVP + Sbjct: 177 PELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVP----KWL 232 Query: 413 SPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPL 447 SP + L Q+L DP +R+ S R + HP Sbjct: 233 SPSSILLLQQMLQVDPKKRI-----SMRNLLNHPW 262 >4B8L-A nrPDB Length = 286 Score = 265 bits (678), Expect = 3e-71, Method: Composition-based stats. Identities = 75/287 (26%), Positives = 133/287 (46%), Gaps = 13/287 (4%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEK 235 + ++ T + F R LGKG FG V + + + A K L K +++K E E Sbjct: 7 MPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREI 66 Query: 236 QILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEI 295 +I + ++ + + + + L+L G+L + G+ F E R+ + E+ Sbjct: 67 EIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGR--FDEQRSATFMEEL 124 Query: 296 CCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPE 355 L H ++++RD+KPEN+L+ G ++I+D G +VH P + + GT+ Y+ PE Sbjct: 125 ADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRR-RTMCGTLDYLPPE 183 Query: 356 VVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQ 415 +++ + + D W G L YE + G PF + + + P S Sbjct: 184 MIEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPP----FLSDG 239 Query: 416 ARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLE 462 ++ L S+LL P +RL +G V EHP K N +R+ G+ + Sbjct: 240 SKDLISKLLRYHPPQRLPLKG-----VMEHPWVK-ANSRRVLPGVYQ 280 >6FDY-U nrPDB Length = 276 Score = 265 bits (678), Expect = 3e-71, Method: Composition-based stats. Identities = 77/267 (28%), Positives = 122/267 (45%), Gaps = 12/267 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQ-VRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 + F LG G + V + T ++ A K + KK + K E L E +IL+ + Sbjct: 11 DGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVEN-LLTEIEILKGIR 69 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 +V L D + L++ GGDL I+ + PE A + ++ L+ L Sbjct: 70 HPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIH--TRRILPEKVARVFMQQLASALQFL 127 Query: 303 HRERIVYRDLKPENILLD--DHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE 360 H I + DLKP+NILL + H++++D G A H+ G+ YMAPE+V Sbjct: 128 HERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQR 187 Query: 361 RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC 420 +Y D W++G +LYE + GQ PF R E++ R + + S R L Sbjct: 188 QYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKI-RSNRVIELPLRPLLSRDCRDLL 246 Query: 421 SQLLCKDPAERLGCRGGSAREVKEHPL 447 +LL +DP+ R+ S ++ HP Sbjct: 247 QRLLERDPSRRI-----SFQDFFAHPW 268 >4YNZ-A nrPDB Length = 342 Score = 264 bits (676), Expect = 6e-71, Method: Composition-based stats. Identities = 79/300 (26%), Positives = 135/300 (45%), Gaps = 20/300 (6%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 +R + LGKG G V T + A K + ++++ E IL+ + Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKL-SESVLMKVEREIAILKLIEHPH 70 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 V+ L YE K L LVL ++GG+L ++ G+ A + +I L+ H Sbjct: 71 VLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGR--LTPKEARKFFRQIISALDFCHSH 128 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYT-F 364 I +RDLKPEN+LLD+ +IRI+D G+A ++ G+ Y PEV++ E+Y Sbjct: 129 SICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGR 188 Query: 365 SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLL 424 D W+ G +L+ ++ G PF + E+V+R V +P P +SL ++ Sbjct: 189 KADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMP----HFIPPDCQSLLRGMI 244 Query: 425 CKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFS 484 D A RL + +++H + +G P +P P+ + + + +E Sbjct: 245 EVDAARRL-----TLEHIQKHIWY-------IGGKNEPEPEQPIPRKVQIRSLPSLEDID 292 >4D2V-A nrPDB Length = 356 Score = 264 bits (676), Expect = 6e-71, Method: Composition-based stats. Identities = 66/281 (23%), Positives = 121/281 (43%), Gaps = 16/281 (5%) Query: 173 WKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMAL 232 ++ + + +G GGF +V TG+M A K ++K + Sbjct: 18 GSHMKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLP--RIK 75 Query: 233 NEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYA 292 E + L+ + + + L + ET + + +VL GG+L +I + E Sbjct: 76 TEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDR--LSEEETRVVF 133 Query: 293 AEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI--KGRVGTVG 350 +I + +H + +RDLKPEN+L D++ +++ D GL + + G + Sbjct: 134 RQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALA 193 Query: 351 YMAPEVVKNERY-TFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYS 409 Y APE+++ + Y D W++G LLY ++ G PF ++ R +VP Sbjct: 194 YAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVP---- 249 Query: 410 ERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 + SP + L Q+L DP +R+ S + + HP + Sbjct: 250 KWLSPSSILLLQQMLQVDPKKRI-----SMKNLLNHPWIMQ 285 >3IS5-A nrPDB Length = 285 Score = 264 bits (675), Expect = 8e-71, Method: Composition-based stats. Identities = 80/293 (27%), Positives = 125/293 (42%), Gaps = 25/293 (8%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI 222 +++YF + F R LG G FG+V + R++G K + K R Sbjct: 12 ENLYFQG-----------TIDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRS 60 Query: 223 KKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG 282 + + A E ++L+ ++ ++ + +E + +V+ GG+L I G Sbjct: 61 QVPMEQIEA--EIEVLKSLDHPNIIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARG 118 Query: 283 --FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDD---HGHIRISDLGLAVHVP 337 E ++ L H + +V++DLKPENIL D H I+I D GLA Sbjct: 119 KALSEGYVAELMKQMMNALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFK 178 Query: 338 EGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEV 397 + GT YMAPEV K TF D W+ G ++Y ++ G PF + +++ Sbjct: 179 SDEHSTNAAGTALYMAPEVFK-RDVTFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQKA 237 Query: 398 ERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 E +PQA L Q+L KDP R SA +V H FK+ Sbjct: 238 TYKEPNYAVECRP-LTPQAVDLLKQMLTKDPERR-----PSAAQVLHHEWFKQ 284 >3DB8-A nrPDB Length = 317 Score = 264 bits (674), Expect = 9e-71, Method: Composition-based stats. Identities = 75/273 (27%), Positives = 127/273 (46%), Gaps = 12/273 (4%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 P T + + R LGKGGF + T +++A K + K + K + E I Sbjct: 37 DPRTMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIH 96 Query: 239 EKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 + +++ VV +E D + +VL + L H + E A ++ + G Sbjct: 97 KSLDNPHVVGFHGFFEDDDFVYVVLEICRRRSLLEL--HKRRKAVTEPEARYFMRQTIQG 154 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVV 357 ++ LH R+++RDLK N+ L+D ++I D GLA + +G+ K GT Y+APEV+ Sbjct: 155 VQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVL 214 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 + ++F D W+LGC+LY ++ G+ PF+ K +++ VP +P A Sbjct: 215 CKKGHSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRIKKNEYSVP----RHINPVAS 270 Query: 418 SLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 +L ++L DP R S E+ F Sbjct: 271 ALIRRMLHADPTLR-----PSVAELLTDEFFTS 298 >4QMW-A nrPDB Length = 310 Score = 263 bits (672), Expect = 2e-70, Method: Composition-based stats. Identities = 66/268 (24%), Positives = 117/268 (43%), Gaps = 14/268 (5%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 + F + +GKG FGEV T K+ A K ++ + + + E +L + Sbjct: 27 PEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQ--QEITVLSQC 84 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 +S +V +Y L +++ + GG + E + EI GL+ Sbjct: 85 DSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLL---EPGPLDETQIATILREILKGLDY 141 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIK-GRVGTVGYMAPEVVKNE 360 LH E+ ++RD+K N+LL +HG ++++D G+A + + Q + VGT +MAPEV+K Sbjct: 142 LHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS 201 Query: 361 RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC 420 Y D W+LG E+ G+ P + + + P +S + Sbjct: 202 AYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPK---NNPPTLEGNYSKPLKEFV 258 Query: 421 SQLLCKDPAERLGCRGGSAREVKEHPLF 448 L K+P+ R +A+E+ +H Sbjct: 259 EACLNKEPSFR-----PTAKELLKHKFI 281 >3ZUT-A nrPDB Length = 362 Score = 263 bits (671), Expect = 2e-70, Method: Composition-based stats. Identities = 68/271 (25%), Positives = 116/271 (42%), Gaps = 16/271 (5%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 + + + +G G FG + + + ++ A K +E+ K + E + Sbjct: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG----EKIDENVKREIINHRSLR 73 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 +V T L +V+ +GG+L I + G+ F E A F+ ++ G+ Sbjct: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSYC 131 Query: 303 HRERIVYRDLKPENILLDDH--GHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE 360 H ++ +RDLK EN LLD ++I G + K VGT Y+APEV+ + Sbjct: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKK 191 Query: 361 RYTFSP-DWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE--RFSPQAR 417 Y D W+ G LY M+ G PF+ ++ + + V + SP+ R Sbjct: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 Query: 418 SLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 L S++ DPA+R+ S E++ H F Sbjct: 252 HLISRIFVADPAKRI-----SIPEIRNHEWF 277 >4CSV-A nrPDB Length = 275 Score = 262 bits (670), Expect = 2e-70, Method: Composition-based stats. Identities = 63/271 (23%), Positives = 112/271 (41%), Gaps = 17/271 (6%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 ++ + ++ R LG G FGEV + R A K L++ + L E Q Sbjct: 4 DKWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMS----VEEFLQEAQ 59 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 I++K+ +V L + + ++ M+ G L ++ + AA++ Sbjct: 60 IMKKLKHPNLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVA 119 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVG---TVGYMA 353 G+ L + ++RDL N L+ ++ ++++D GLA + E + R G + + A Sbjct: 120 SGMAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDE-YTARAGAKFPIKWTA 178 Query: 354 PEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERF 412 PE + R++ D WA G LL+E+ GQ P+ E+VER + + Sbjct: 179 PEAISYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRM---PRPQGC 235 Query: 413 SPQARSLCSQLLCKDPAERLGCRGGSAREVK 443 + L Q K P ER + E Sbjct: 236 PEEIYELMLQCWNKSPEER-----PTFAETL 261 >3UC3-A nrPDB Length = 361 Score = 262 bits (670), Expect = 2e-70, Method: Composition-based stats. Identities = 76/294 (25%), Positives = 125/294 (42%), Gaps = 26/294 (8%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 + + + +G G FG + + T ++ A K +E+ + E + Sbjct: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAIDENVQ----REIINHRSLR 74 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 +V T L +++ +GG+L I + G+ F E A F+ ++ G+ Sbjct: 75 HPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGR--FSEDEARFFFQQLLSGVSYC 132 Query: 303 HRERIVYRDLKPENILLDDH--GHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE 360 H +I +RDLK EN LLD ++I D G + K VGT Y+APEV+ + Sbjct: 133 HSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQ 192 Query: 361 RYTFS-PDWWALGCLLYEMIAGQSPFQQ----RKKKIKREEVERLVKEVPEEYSERFSPQ 415 Y D W+ G LY M+ G PF+ R + + + + +P++ R SP+ Sbjct: 193 EYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI--RISPE 250 Query: 416 ARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK------LNFKRLGAGMLEP 463 L S++ DPA R+ S E+K H F K +N G+ EP Sbjct: 251 CCHLISRIFVADPATRI-----SIPEIKTHSWFLKNLPADLMNESNTGSQFQEP 299 >4B6L-A nrPDB Length = 281 Score = 261 bits (667), Expect = 7e-70, Method: Composition-based stats. Identities = 79/273 (28%), Positives = 129/273 (47%), Gaps = 12/273 (4%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 P + T+ + R+LGKGGF TG YA K + + R+ K LNE ++ Sbjct: 4 DPRSGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELH 63 Query: 239 EKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 + R +V ++ +E D + + L L + L HI+ + E +Y +I G Sbjct: 64 RDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLA-HIWK-ARHTLLEPEVRYYLRQILSG 121 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV-PEGQTIKGRVGTVGYMAPEVV 357 L+ LH+ I++RDLK N + ++ +++ D GLA + P Q K GT Y+APEV+ Sbjct: 122 LKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVL 181 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 + + D W+LGC++Y ++ G PF+ +E R +K+V S AR Sbjct: 182 LRQGHGPEADVWSLGCVMYTLLCGSPPFETAD----LKETYRCIKQVHYTLPASLSLPAR 237 Query: 418 SLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 L + +L P +R S ++ H F K Sbjct: 238 QLLAAILRASPRDR-----PSIDQILRHDFFTK 265 >3DAK-A nrPDB Length = 290 Score = 261 bits (667), Expect = 7e-70, Method: Composition-based stats. Identities = 75/293 (25%), Positives = 129/293 (44%), Gaps = 30/293 (10%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 + ++ + V+G G V A + A K++ ++ + E L E Q + Sbjct: 5 WSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDE--LLKEIQAM 62 Query: 239 EKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG------FPEARAVFYA 292 + + +VS ++ KD L LV+ L++GG + I H+ G E+ Sbjct: 63 SQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATIL 122 Query: 293 AEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEG------QTIKGRV 346 E+ GLE LH+ ++RD+K NILL + G ++I+D G++ + G + K V Sbjct: 123 REVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFV 182 Query: 347 GTVGYMAPEVVKN-ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVP 405 GT +MAPEV++ Y F D W+ G E+ G +P+ + + L + P Sbjct: 183 GTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVL--MLTLQNDPP 240 Query: 406 E--------EYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 E +++ R + S L KDP +R +A E+ H F+K Sbjct: 241 SLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKR-----PTAAELLRHKFFQK 288 >3Q53-A nrPDB Length = 306 Score = 260 bits (665), Expect = 1e-69, Method: Composition-based stats. Identities = 68/269 (25%), Positives = 122/269 (45%), Gaps = 13/269 (4%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 K + ++ +G+G G V ATG+ A +++ ++++ + + +NE ++ + Sbjct: 19 PKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMN---LQQQPKKELIINEILVMREN 75 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 + +V+ +Y D L +V+ + GG L + E + E LE Sbjct: 76 KNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC---MDEGQIAAVCRECLQALEF 132 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV-PEGQTIKGRVGTVGYMAPEVVKNE 360 LH ++++RD+K +NILL G ++++D G + PE VGT +MAPEVV + Sbjct: 133 LHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRK 192 Query: 361 RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC 420 Y D W+LG + EMI G+ P+ + + E+ S R Sbjct: 193 AYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIAT-NGTPELQNPEKLSAIFRDFL 251 Query: 421 SQLLCKDPAERLGCRGGSAREVKEHPLFK 449 ++ L D +R GSA+E+ +H K Sbjct: 252 NRCLEMDVEKR-----GSAKELIQHQFLK 275 >3UDB-A nrPDB Length = 317 Score = 260 bits (665), Expect = 1e-69, Method: Composition-based stats. Identities = 69/271 (25%), Positives = 117/271 (43%), Gaps = 16/271 (5%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 + + + +G G FG + + ++ A K +E+ K + E + Sbjct: 18 SDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERG----EKIDENVKREIINHRSLR 73 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 +V T L +V+ +GG+L I + G+ F E A F+ ++ G+ Sbjct: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGR--FSEDEARFFFQQLISGVSYA 131 Query: 303 HRERIVYRDLKPENILLDDH--GHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE 360 H ++ +RDLK EN LLD ++I+D G + K VGT Y+APEV+ + Sbjct: 132 HAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLLKK 191 Query: 361 RYTFSP-DWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE--RFSPQAR 417 Y D W+ G LY M+ G PF+ ++ + + V + SP+ R Sbjct: 192 EYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 Query: 418 SLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 L S++ DPA+R+ S E++ H F Sbjct: 252 HLISRIFVADPAKRI-----SIPEIRNHEWF 277 >6CMJ-A nrPDB Length = 321 Score = 259 bits (663), Expect = 2e-69, Method: Composition-based stats. Identities = 79/299 (26%), Positives = 134/299 (44%), Gaps = 24/299 (8%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKR- 221 +++YF + V + + +GKG +G V YA K L KK+ Sbjct: 13 ENLYFQGHHVSITGMQDCVQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKL 72 Query: 222 -------IKKRKGEAMALNEKQILEKVNSRFVVSLAYAYET--KDALCLVLTLMNGGDLK 272 I+ R E IL+K++ VV L + +D L +V L+N G + Sbjct: 73 IRQAGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVM 132 Query: 273 FHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGL 332 E +A FY ++ G+E LH ++I++RD+KP N+L+ + GHI+I+D G+ Sbjct: 133 EV---PTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGV 189 Query: 333 AVHVPEGQ-TIKGRVGTVGYMAPEVVKNER--YTFSP-DWWALGCLLYEMIAGQSPFQQR 388 + + VGT +MAPE + R ++ D WA+G LY + GQ PF Sbjct: 190 SNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDE 249 Query: 389 KKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPL 447 + +++ E P++ + + L +++L K+P R+ E+K HP Sbjct: 250 RIMCLHSKIKSQALEFPDQ--PDIAEDLKDLITRMLDKNPESRIV-----VPEIKLHPW 301 >4I6B-A nrPDB Length = 308 Score = 259 bits (662), Expect = 2e-69, Method: Composition-based stats. Identities = 67/273 (24%), Positives = 124/273 (45%), Gaps = 12/273 (4%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 P T + + + LGKGGF + K+YA K + R+ K E ++ Sbjct: 23 DPTTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELH 82 Query: 239 EKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 ++ + VV + +E K+ + ++L + + + + E +Y +I G Sbjct: 83 RILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILK--ARKVLTEPEVRYYLRQIVSG 140 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPE-GQTIKGRVGTVGYMAPEVV 357 L+ LH + I++RDLK N +++ +++ D GLA + + GT Y++PEV+ Sbjct: 141 LKYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL 200 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 + + D WALGC++Y M+ G+ PF+ K + +P S +P A+ Sbjct: 201 NKQGHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMP---SSLLAP-AK 256 Query: 418 SLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 L + +L K+P +R S ++ H F + Sbjct: 257 HLIASMLSKNPEDR-----PSLDDIIRHDFFTQ 284 >3FXW-A nrPDB Length = 336 Score = 259 bits (662), Expect = 3e-69, Method: Composition-based stats. Identities = 75/298 (25%), Positives = 122/298 (40%), Gaps = 24/298 (8%) Query: 164 SIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIK 223 S Q ++ VT + +VLG G G+V C R TG+ A K L Sbjct: 9 SSGLEVLFQGPEPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKA 68 Query: 224 KRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDA----LCLVLTLMNGGDLKFHIYHMG 279 +++ + + +V + YE L +++ M GG+L I G Sbjct: 69 RQEVDHHW-------QASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERG 121 Query: 280 QAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILL---DDHGHIRISDLGLAVHV 336 F E A +I ++ LH I +RD+KPEN+L + ++++D G A Sbjct: 122 DQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKET 181 Query: 337 PEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREE 396 + ++ T Y+APEV+ E+Y S D W+LG ++Y ++ G PF + Sbjct: 182 TQN-ALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPG 240 Query: 397 VERLV----KEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 ++R + P S A+ L LL DP ERL + + HP + Sbjct: 241 MKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERL-----TITQFMNHPWINQ 293 >4KS7-A nrPDB Length = 292 Score = 259 bits (661), Expect = 3e-69, Method: Composition-based stats. Identities = 68/263 (25%), Positives = 125/263 (47%), Gaps = 17/263 (6%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLA 250 +G+G G VC + + +G+ A K ++ ++K++ + NE I+ VV + Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMMD---LRKQQRRELLFNEVVIMRDYQHFNVVEMY 86 Query: 251 YAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYR 310 +Y + L +++ + GG L + Q E + + L LH + +++R Sbjct: 87 KSYLVGEELWVLMEFLQGGALTDIV---SQVRLNEEQIATVCEAVLQALAYLHAQGVIHR 143 Query: 311 DLKPENILLDDHGHIRISDLGLAVHVPEGQ-TIKGRVGTVGYMAPEVVKNERYTFSPDWW 369 D+K ++ILL G +++SD G + + K VGT +MAPEV+ Y D W Sbjct: 144 DIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIW 203 Query: 370 ALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEY--SERFSPQARSLCSQLLCKD 427 +LG ++ EM+ G+ P+ + ++RL P + S + SP R ++L +D Sbjct: 204 SLGIMVIEMVDGEPPYFSDSPV---QAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRD 260 Query: 428 PAERLGCRGGSAREVKEHPLFKK 450 P ER +A+E+ +HP + Sbjct: 261 PQER-----ATAQELLDHPFLLQ 278 >4AF3-A nrPDB Length = 292 Score = 258 bits (660), Expect = 4e-69, Method: Composition-based stats. Identities = 78/286 (27%), Positives = 131/286 (45%), Gaps = 18/286 (6%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 + T + F R LGKG FG V + + + + A K L K +I+K E E +I Sbjct: 18 RHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQ 77 Query: 239 EKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 ++ ++ L + + + L+L G+L + F E R E+ Sbjct: 78 AHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSC--TFDEQRTATIMEELADA 135 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVK 358 L H +++++RD+KPEN+LL G ++I+D G +VH P + K GT+ Y+ PE+++ Sbjct: 136 LMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRR-KTMCGTLDYLPPEMIE 194 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARS 418 + D W +G L YE++ G PF + E R + +V ++ A+ Sbjct: 195 GRMHNEKVDLWCIGVLCYELLVGNPPF----ESASHNETYRRIVKVDLKFPASVPTGAQD 250 Query: 419 LCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPP 464 L S+LL +P+ERL SA HP + + + PP Sbjct: 251 LISKLLRHNPSERLPLAQVSA-----HPWVRA------NSRRVLPP 285 >1CM8-A nrPDB Length = 367 Score = 258 bits (659), Expect = 5e-69, Method: Composition-based stats. Identities = 81/305 (26%), Positives = 134/305 (43%), Gaps = 46/305 (15%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 + +R + +G G +G VC+ TG A KKL + + A E ++L+ + Sbjct: 23 VRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP-FQSELFAKRAYRELRLLKHM 81 Query: 242 NSRFVVSLAYAYETKDAL------CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEI 295 V+ L + + L LV+ M G DL + H E R F ++ Sbjct: 82 RHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH---EKLGEDRIQFLVYQM 137 Query: 296 CCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPE 355 GL +H I++RDLKP N+ +++ ++I D GLA + G V T Y APE Sbjct: 138 LKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ--ADSEMTGYVVTRWYRAPE 195 Query: 356 VVKN-ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERF-- 412 V+ N RYT + D W++GC++ EMI G++ F+ + +E+ ++ P E+ +R Sbjct: 196 VILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQS 255 Query: 413 -------------------------SPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPL 447 SP A +L ++L D +R+ +A E HP Sbjct: 256 DEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV-----TAGEALAHPY 310 Query: 448 FKKLN 452 F+ L+ Sbjct: 311 FESLH 315 >2XIK-A nrPDB Length = 294 Score = 258 bits (659), Expect = 6e-69, Method: Composition-based stats. Identities = 66/272 (24%), Positives = 115/272 (42%), Gaps = 14/272 (5%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 + F + +GKG FGEV T ++ A K ++ + + + E +L + Sbjct: 17 PEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQ--QEITVLSQC 74 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 +S ++ +Y L +++ + GG + E EI GL+ Sbjct: 75 DSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK---PGPLEETYIATILREILKGLDY 131 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIK-GRVGTVGYMAPEVVKNE 360 LH ER ++RD+K N+LL + G ++++D G+A + + Q + VGT +MAPEV+K Sbjct: 132 LHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS 191 Query: 361 RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC 420 Y F D W+LG E+ G+ P + + P + S + Sbjct: 192 AYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPK---NSPPTLEGQHSKPFKEFV 248 Query: 421 SQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 L KDP R +A+E+ +H + Sbjct: 249 EACLNKDPRFR-----PTAKELLKHKFITRYT 275 >6HXF-B nrPDB Length = 302 Score = 257 bits (658), Expect = 6e-69, Method: Composition-based stats. Identities = 71/296 (23%), Positives = 127/296 (42%), Gaps = 16/296 (5%) Query: 172 QWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMA 231 +++ + R + LG G FG+V + + TG + A K +E K + Sbjct: 7 EYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIE---TKSEEELEDY 63 Query: 232 LNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFY 291 + E +IL + ++V L AY L +++ GG + + + + G E + Sbjct: 64 IVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDR-GLTEPQIQVV 122 Query: 292 AAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGL-AVHVPEGQTIKGRVGTVG 350 ++ L LH +RI++RDLK N+L+ G IR++D G+ A ++ Q +GT Sbjct: 123 CRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPY 182 Query: 351 YMAPEVVK-----NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVP 405 +MAPEVV + Y + D W+LG L EM + P + ++ + Sbjct: 183 WMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDP-PT 241 Query: 406 EEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGML 461 ++S + R L K+P R SA ++ EHP + + ++ Sbjct: 242 LLTPSKWSVEFRDFLKIALDKNPETR-----PSAAQLLEHPFVSSITSNKALRELV 292 >4KRC-A nrPDB Length = 317 Score = 257 bits (658), Expect = 7e-69, Method: Composition-based stats. Identities = 70/303 (23%), Positives = 123/303 (40%), Gaps = 44/303 (14%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 F+Q LG G + V + TG A K+++ + + A+ E +++++ Sbjct: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD--SEEGTPSTAIREISLMKELKHE 63 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMG----QAGFPEARAVFYAAEICCGLE 300 +V L T++ L LV M+ DLK ++ G ++ ++ GL Sbjct: 64 NIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLA 122 Query: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKN 359 H +I++RDLKP+N+L++ G +++ D GLA T V T+ Y AP+V+ Sbjct: 123 FCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMG 182 Query: 360 ER-YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR- 417 R Y+ S D W+ GC+L EMI G+ F + + + + ++ E + + Sbjct: 183 SRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKY 242 Query: 418 -----------------------------SLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 LL +P RL SA++ HP F Sbjct: 243 NPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRL-----SAKQALHHPWF 297 Query: 449 KKL 451 + Sbjct: 298 AEY 300 >4FZF-B nrPDB Length = 283 Score = 257 bits (657), Expect = 9e-69, Method: Composition-based stats. Identities = 65/270 (24%), Positives = 116/270 (42%), Gaps = 14/270 (5%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 + F + +GKG FGEV T ++ A K ++ + + + E +L + Sbjct: 6 PEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQ--QEITVLSQC 63 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 +S +V +Y L +++ + GG + F E + EI GL+ Sbjct: 64 DSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA---GPFDEFQIATMLKEILKGLDY 120 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIK-GRVGTVGYMAPEVVKNE 360 LH E+ ++RD+K N+LL + G ++++ G+A + + Q + VGT +MAPEV++ Sbjct: 121 LHSEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQS 180 Query: 361 RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC 420 Y D W+LG E+ G+ P + + P F+ + Sbjct: 181 AYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPK---NNPPTLVGDFTKSFKEFI 237 Query: 421 SQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 L KDP+ R +A+E+ +H K Sbjct: 238 DACLNKDPSFR-----PTAKELLKHKFIVK 262 >2WQN-A nrPDB Length = 310 Score = 257 bits (656), Expect = 1e-68, Method: Composition-based stats. Identities = 78/250 (31%), Positives = 120/250 (48%), Gaps = 3/250 (1%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 FR + +G+G F EV G A KK++ + K A + E +L+++N Sbjct: 33 NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHP 92 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG--FPEARAVFYAAEICCGLEDL 302 V+ ++ + L +VL L + GDL I H + PE Y ++C LE + Sbjct: 93 NVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHM 152 Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI-KGRVGTVGYMAPEVVKNER 361 H R+++RD+KP N+ + G +++ DLGL T VGT YM+PE + Sbjct: 153 HSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENG 212 Query: 362 YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCS 421 Y F D W+LGCLLYEM A QSPF K + + + P S+ +S + R L + Sbjct: 213 YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVN 272 Query: 422 QLLCKDPAER 431 + DP +R Sbjct: 273 MCINPDPEKR 282 >3LM0-A nrPDB Length = 327 Score = 256 bits (654), Expect = 2e-68, Method: Composition-based stats. Identities = 79/302 (26%), Positives = 134/302 (44%), Gaps = 22/302 (7%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQY--RVLGKGGFGEVCACQVRATGKMYACKKLEKK 220 +++YF + N F + LG+G F V C ++TG+ YA K L+K+ Sbjct: 16 ENLYFQSMENF----------NNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKR 65 Query: 221 RIKKRKGEAMALNEKQILEKVNS-RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMG 279 R + + A L+E +LE S V++L YE + L+L GG++ Sbjct: 66 R-RGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPEL 124 Query: 280 QAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDD---HGHIRISDLGLAVHV 336 E + +I G+ LH+ IV+ DLKP+NILL G I+I D G++ + Sbjct: 125 AEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKI 184 Query: 337 PEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREE 396 ++ +GT Y+APE++ + T + D W +G + Y ++ SPF + Sbjct: 185 GHACELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLN 244 Query: 397 VERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRL 456 + ++ + EE S A LL K+P +R +A H ++ +F+ L Sbjct: 245 ISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKR-----PTAEICLSHSWLQQWDFENL 299 Query: 457 GA 458 Sbjct: 300 FH 301 >3KN6-A nrPDB Length = 325 Score = 256 bits (653), Expect = 3e-68, Method: Composition-based stats. Identities = 75/267 (28%), Positives = 123/267 (46%), Gaps = 20/267 (7%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV-NSRFVVS 248 + LG+G F C + + + +A K + K+ EA E L+ +V Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRM------EANTQKEITALKLCEGHPNIVK 70 Query: 249 LAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIV 308 L + + LV+ L+NGG+L I + F E A + ++ + +H +V Sbjct: 71 LHEVFHDQLHTFLVMELLNGGELFERIKK--KKHFSETEASYIMRKLVSAVSHMHDVGVV 128 Query: 309 YRDLKPENILL---DDHGHIRISDLGLAV-HVPEGQTIKGRVGTVGYMAPEVVKNERYTF 364 +RDLKPEN+L +D+ I+I D G A P+ Q +K T+ Y APE++ Y Sbjct: 129 HRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDE 188 Query: 365 SPDWWALGCLLYEMIAGQSPFQQRKKKIK-------REEVERLVKEVPEEYSERFSPQAR 417 S D W+LG +LY M++GQ PFQ + + +++++ E + S +A+ Sbjct: 189 SCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAK 248 Query: 418 SLCSQLLCKDPAERLGCRGGSAREVKE 444 L LL DP +RL G E + Sbjct: 249 DLIQGLLTVDPNKRLKMSGLRYNEWLQ 275 >2Q0N-A nrPDB Length = 301 Score = 255 bits (651), Expect = 5e-68, Method: Composition-based stats. Identities = 81/311 (26%), Positives = 140/311 (45%), Gaps = 33/311 (10%) Query: 143 QELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCA 202 +E R++HE A LQ P ++ + +G+G G VC Sbjct: 4 REPQRVSHEQFRAA--------------LQLVVDPGDP--RSYLDNFIKIGEGSTGIVCI 47 Query: 203 CQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLV 262 VR++GK+ A KK++ ++K++ + NE I+ VV + +Y D L +V Sbjct: 48 ATVRSSGKLVAVKKMD---LRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVV 104 Query: 263 LTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDH 322 + + GG L + H E + + L LH + +++RD+K ++ILL Sbjct: 105 MEFLEGGALTDIVTHT---RMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHD 161 Query: 323 GHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAG 381 G +++SD G V E K VGT +MAPE++ Y D W+LG ++ EM+ G Sbjct: 162 GRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDG 221 Query: 382 QSPFQQRKKKIKREEVERLVKEVPEEYS--ERFSPQARSLCSQLLCKDPAERLGCRGGSA 439 + P+ + ++ + +P + SP + +LL +DPA+R +A Sbjct: 222 EPPYFNEPP---LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQR-----ATA 273 Query: 440 REVKEHPLFKK 450 E+ +HP K Sbjct: 274 AELLKHPFLAK 284 >5D7A-A nrPDB Length = 308 Score = 254 bits (650), Expect = 6e-68, Method: Composition-based stats. Identities = 63/278 (22%), Positives = 118/278 (42%), Gaps = 24/278 (8%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV-NSR 244 F ++G G +G+V + TG++ A K ++ E E +L+K + R Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG----DEEEEIKQEINMLKKYSHHR 74 Query: 245 FVVSLAYAYETKDA------LCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 + + A+ K+ L LV+ G + I + E + EI G Sbjct: 75 NIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRG 134 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEG-QTIKGRVGTVGYMAPEVV 357 L LH+ ++++RD+K +N+LL ++ +++ D G++ + +GT +MAPEV+ Sbjct: 135 LSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVI 194 Query: 358 K-----NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERF 412 + Y F D W+LG EM G P + R P S+++ Sbjct: 195 ACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPR--NPAPRLKSKKW 252 Query: 413 SPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 S + +S L K+ ++R + ++ +HP + Sbjct: 253 SKKFQSFIESCLVKNHSQR-----PATEQLMKHPFIRD 285 >4JDH-A nrPDB Length = 346 Score = 254 bits (649), Expect = 7e-68, Method: Composition-based stats. Identities = 81/311 (26%), Positives = 140/311 (45%), Gaps = 33/311 (10%) Query: 143 QELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCA 202 +E R++HE A LQ P ++ + +G+G G VC Sbjct: 49 REPQRVSHEQFRAA--------------LQLVVDPGDP--RSYLDNFIKIGEGSTGIVCI 92 Query: 203 CQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLV 262 VR++GK+ A KK++ ++K++ + NE I+ VV + +Y D L +V Sbjct: 93 ATVRSSGKLVAVKKMD---LRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVV 149 Query: 263 LTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDH 322 + + GG L + H E + + L LH + +++RD+K ++ILL Sbjct: 150 MEFLEGGALTDIVTHT---RMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHD 206 Query: 323 GHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAG 381 G +++SD G V E K VGT +MAPE++ Y D W+LG ++ EM+ G Sbjct: 207 GRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDG 266 Query: 382 QSPFQQRKKKIKREEVERLVKEVPEEYS--ERFSPQARSLCSQLLCKDPAERLGCRGGSA 439 + P+ + ++ + +P + SP + +LL +DPA+R +A Sbjct: 267 EPPYFNEPP---LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQR-----ATA 318 Query: 440 REVKEHPLFKK 450 E+ +HP K Sbjct: 319 AELLKHPFLAK 329 >4XBR-A nrPDB Length = 366 Score = 254 bits (649), Expect = 8e-68, Method: Composition-based stats. Identities = 81/311 (26%), Positives = 140/311 (45%), Gaps = 33/311 (10%) Query: 143 QELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCA 202 +E R++HE A LQ P ++ + +G+G G VC Sbjct: 69 REPQRVSHEQFRAA--------------LQLVVDPGDP--RSYLDNFIKIGEGSTGIVCI 112 Query: 203 CQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLV 262 VR++GK+ A KK++ ++K++ + NE I+ VV + +Y D L +V Sbjct: 113 ATVRSSGKLVAVKKMD---LRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVV 169 Query: 263 LTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDH 322 + + GG L + H E + + L LH + +++RD+K ++ILL Sbjct: 170 MEFLEGGALTDIVTHT---RMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHD 226 Query: 323 GHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAG 381 G +++SD G V E K VGT +MAPE++ Y D W+LG ++ EM+ G Sbjct: 227 GRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDG 286 Query: 382 QSPFQQRKKKIKREEVERLVKEVPEEYS--ERFSPQARSLCSQLLCKDPAERLGCRGGSA 439 + P+ + ++ + +P + SP + +LL +DPA+R +A Sbjct: 287 EPPYFNEPP---LKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQR-----ATA 338 Query: 440 REVKEHPLFKK 450 E+ +HP K Sbjct: 339 AELLKHPFLAK 349 >4FIE-A nrPDB Length = 423 Score = 254 bits (648), Expect = 1e-67, Method: Composition-based stats. Identities = 83/334 (24%), Positives = 144/334 (43%), Gaps = 35/334 (10%) Query: 122 PRQLVTNCTQRLEQGPCKDLF--QELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQ 179 P + + P +E R++HE A LQ Sbjct: 103 PPPARARQENGMPEKPPGPRSPQREPQRVSHEQFRAA--------------LQLVVDPGD 148 Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 P ++ + +G+G G VC VR++GK+ A KK++ ++K++ + NE I+ Sbjct: 149 P--RSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMD---LRKQQRRELLFNEVVIMR 203 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 VV + +Y D L +V+ + GG L + H E + + L Sbjct: 204 DYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHT---RMNEEQIAAVCLAVLQAL 260 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVK 358 LH + +++RD+K ++ILL G +++SD G V E K VGT +MAPE++ Sbjct: 261 SVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELIS 320 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYS--ERFSPQA 416 Y D W+LG ++ EM+ G+ P+ + ++ + +P + SP Sbjct: 321 RLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPP---LKAMKMIRDNLPPRLKNLHKVSPSL 377 Query: 417 RSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 + +LL +DPA+R +A E+ +HP K Sbjct: 378 KGFLDRLLVRDPAQR-----ATAAELLKHPFLAK 406 >4APC-A nrPDB Length = 350 Score = 254 bits (648), Expect = 1e-67, Method: Composition-based stats. Identities = 69/283 (24%), Positives = 128/283 (45%), Gaps = 23/283 (8%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI 222 +++YF + + + +G+G FG+ + G+ Y K++ R+ Sbjct: 16 ENLYFQSM-------------EKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRM 62 Query: 223 KKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG 282 ++ E E +L + +V ++E +L +V+ GGDL I Sbjct: 63 SSKEREES-RREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVL 121 Query: 283 FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEG-QT 341 F E + + + +IC L+ +H +I++RD+K +NI L G +++ D G+A + + Sbjct: 122 FQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVEL 181 Query: 342 IKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLV 401 + +GT Y++PE+ +N+ Y D WALGC+LYE+ + F+ K ++ Sbjct: 182 ARACIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGS 241 Query: 402 KEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKE 444 S +S RSL SQL ++P +R S + E Sbjct: 242 F---PPVSLHYSYDLRSLVSQLFKRNPRDR-----PSVNSILE 276 >4J52-A nrPDB Length = 293 Score = 253 bits (647), Expect = 1e-67, Method: Composition-based stats. Identities = 73/260 (28%), Positives = 121/260 (46%), Gaps = 12/260 (4%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 LGKGGF + T +++A K + K + K E I + + VV Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 +E D + +VL L L H + E A +Y +I G + LHR R+++RD Sbjct: 82 FFEDNDFVFVVLELCRRRSLLEL--HKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRD 139 Query: 312 LKPENILLDDHGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWA 370 LK N+ L++ ++I D GLA V +G+ K GT Y+APEV+ + ++F D W+ Sbjct: 140 LKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWS 199 Query: 371 LGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAE 430 +GC++Y ++ G+ PF+ K +++ +P + +P A SL ++L DP Sbjct: 200 IGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIP----KHINPVAASLIQKMLQTDPTA 255 Query: 431 RLGCRGGSAREVKEHPLFKK 450 R + E+ F Sbjct: 256 R-----PTINELLNDEFFTS 270 >4EWQ-A nrPDB Length = 383 Score = 253 bits (647), Expect = 1e-67, Method: Composition-based stats. Identities = 83/382 (21%), Positives = 150/382 (39%), Gaps = 65/382 (17%) Query: 163 DSIYFNR---------FLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYA 213 +++YF + Q V ++ +G G +G VCA TG A Sbjct: 16 ENLYFQSNASQERPTFYRQELNKTIWEVP-ERYQNLSPVGSGAYGSVCAAFDTKTGLRVA 74 Query: 214 CKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAY------ETKDALCLVLTLMN 267 KKL + + E ++L+ + V+ L + E + + LV LM Sbjct: 75 VKKLSRP-FQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM- 132 Query: 268 GGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRI 327 G DL + + F +I GL+ +H I++RDLKP N+ +++ ++I Sbjct: 133 GADLNNIVKC---QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKI 189 Query: 328 SDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN-ERYTFSPDWWALGCLLYEMIAGQSPFQ 386 D GLA H + + G V T Y APE++ N Y + D W++GC++ E++ G++ F Sbjct: 190 LDFGLARHTDD--EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFP 247 Query: 387 QRKKKIKREEVERLVKEVPEEYSERFSPQ---------------------------ARSL 419 + + + RLV E ++ S + A L Sbjct: 248 GTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDL 307 Query: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKD--V 477 ++L D +R+ +A + H F + + EP P Q+ +D + Sbjct: 308 LEKMLVLDSDKRI-----TAAQALAHAYFAQYHDPD-----DEPVADPYDQSFESRDLLI 357 Query: 478 LDIEQFSTVKGVELEPT--DQD 497 + + + + + P DQ+ Sbjct: 358 DEWKSLTYDEVISFVPPPLDQE 379 >2OU7-A nrPDB Length = 335 Score = 253 bits (647), Expect = 1e-67, Method: Composition-based stats. Identities = 73/260 (28%), Positives = 121/260 (46%), Gaps = 12/260 (4%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 LGKGGF + T +++A K + K + K E I + + VV Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 +E D + +VL L L H + E A +Y +I G + LHR R+++RD Sbjct: 109 FFEDNDFVFVVLELCRRRSLLEL--HKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRD 166 Query: 312 LKPENILLDDHGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWA 370 LK N+ L++ ++I D GLA V +G+ K GT Y+APEV+ + ++F D W+ Sbjct: 167 LKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWS 226 Query: 371 LGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAE 430 +GC++Y ++ G+ PF+ K +++ +P + +P A SL ++L DP Sbjct: 227 IGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIP----KHINPVAASLIQKMLQTDPTA 282 Query: 431 RLGCRGGSAREVKEHPLFKK 450 R + E+ F Sbjct: 283 R-----PTINELLNDEFFTS 297 >5YV8-A nrPDB Length = 298 Score = 252 bits (645), Expect = 2e-67, Method: Composition-based stats. Identities = 78/296 (26%), Positives = 128/296 (43%), Gaps = 39/296 (13%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKR------------------- 221 V N + +GKG +G V YA K L KK+ Sbjct: 10 VQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPA 69 Query: 222 ----IKKRKGEAMALNEKQILEKVNSRFVVSLAYAYET--KDALCLVLTLMNGGDLKFHI 275 I+ R E IL+K++ VV L + +D L +V L+N G + Sbjct: 70 PGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEV- 128 Query: 276 YHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVH 335 E +A FY ++ G+E LH ++I++RD+KP N+L+ + GHI+I+D G++ Sbjct: 129 --PTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNE 186 Query: 336 VPEGQ-TIKGRVGTVGYMAPEVVKNER--YTFSP-DWWALGCLLYEMIAGQSPFQQRKKK 391 + VGT +MAPE + R ++ D WA+G LY + GQ PF + Sbjct: 187 FKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIM 246 Query: 392 IKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPL 447 +++ E P++ + + L +++L K+P R+ E+K HP Sbjct: 247 CLHSKIKSQALEFPDQ--PDIAEDLKDLITRMLDKNPESRIV-----VPEIKLHPW 295 >4AGU-A nrPDB Length = 311 Score = 252 bits (644), Expect = 3e-67, Method: Composition-based stats. Identities = 70/311 (22%), Positives = 125/311 (40%), Gaps = 37/311 (11%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 + + +G+G +G V C+ R TG++ A KK + + +AL E ++L+++ Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESE-DDPVIKKIALREIRMLKQLK 60 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 +V+L + K L LV + L H Q G PE + + Sbjct: 61 HPNLVNLLEVFRRKRRLHLVFEYCDHTVL--HELDRYQRGVPEHLVKSITWQTLQAVNFC 118 Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKNE- 360 H+ ++RD+KPENIL+ H I++ D G A + V T Y +PE++ + Sbjct: 119 HKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDT 178 Query: 361 RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQ----- 415 +Y D WA+GC+ E+++G + + + + + + ++ + + FS Sbjct: 179 QYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSG 238 Query: 416 ----------------------ARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNF 453 A L L DP ERL C ++ HP F+ + Sbjct: 239 VKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTC-----EQLLHHPYFENIRE 293 Query: 454 KRLGAGMLEPP 464 A + P Sbjct: 294 IEDLAKEHDKP 304 >5DBX-A nrPDB Length = 328 Score = 252 bits (643), Expect = 4e-67, Method: Composition-based stats. Identities = 76/293 (25%), Positives = 130/293 (44%), Gaps = 30/293 (10%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 P+ ++ + V+G G V A + + A K++ ++ + E L E Q + Sbjct: 6 WPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDE--LLKEIQAM 63 Query: 239 EKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIY------HMGQAGFPEARAVFYA 292 + + VV+ ++ KD L LV+ L++GG + I EA Sbjct: 64 SQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATIL 123 Query: 293 AEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI------KGRV 346 E+ GL+ LHR ++RDLK NILL + G ++I+D G++ + G + K V Sbjct: 124 KEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFV 183 Query: 347 GTVGYMAPEVVKN-ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVP 405 GT +MAPEV++ Y F D W+ G E+ G +P+ + + L + P Sbjct: 184 GTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVL--MLTLQNDPP 241 Query: 406 --------EEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 +E +++ R L S L KDP++R +A E+ + F+K Sbjct: 242 TLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKR-----PTAAELLKCKFFQK 289 >1NY3-A nrPDB Length = 400 Score = 252 bits (643), Expect = 4e-67, Method: Composition-based stats. Identities = 67/285 (23%), Positives = 118/285 (41%), Gaps = 24/285 (8%) Query: 178 RQPVTKNTFRQ-YRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 ++ + ++ +VLG G G+V + T + +A K L+ +R+ E Sbjct: 55 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHW----- 109 Query: 237 ILEKVNSRFVVSLAYAYET----KDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYA 292 +V + YE + L +V+ ++GG+L I G F E A Sbjct: 110 --RASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIM 167 Query: 293 AEICCGLEDLHRERIVYRDLKPENILLDD---HGHIRISDLGLAVHVPEGQTIKGRVGTV 349 I ++ LH I +RD+KPEN+L + ++++D G A ++ T Sbjct: 168 KSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTP 227 Query: 350 GYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLV----KEVP 405 Y+APEV+ E+Y S D W+LG ++Y ++ G PF ++ + E P Sbjct: 228 YYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 287 Query: 406 EEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 S + + L LL +P +R+ + E HP + Sbjct: 288 NPEWSEVSEEVKMLIRNLLKTEPTQRM-----TITEFMNHPWIMQ 327 >2OZA-A nrPDB Length = 356 Score = 251 bits (642), Expect = 5e-67, Method: Composition-based stats. Identities = 67/285 (23%), Positives = 118/285 (41%), Gaps = 24/285 (8%) Query: 178 RQPVTKNTFRQ-YRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 ++ + ++ +VLG G G+V + T + +A K L+ +R+ E Sbjct: 11 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHW----- 65 Query: 237 ILEKVNSRFVVSLAYAYET----KDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYA 292 +V + YE + L +V+ ++GG+L I G F E A Sbjct: 66 --RASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIM 123 Query: 293 AEICCGLEDLHRERIVYRDLKPENILLDD---HGHIRISDLGLAVHVPEGQTIKGRVGTV 349 I ++ LH I +RD+KPEN+L + ++++D G A ++ T Sbjct: 124 KSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTP 183 Query: 350 GYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLV----KEVP 405 Y+APEV+ E+Y S D W+LG ++Y ++ G PF ++ + E P Sbjct: 184 YYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 243 Query: 406 EEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 S + + L LL +P +R+ + E HP + Sbjct: 244 NPEWSEVSEEVKMLIRNLLKTEPTQRM-----TITEFMNHPWIMQ 283 >1G3N-A nrPDB Length = 326 Score = 251 bits (641), Expect = 6e-67, Method: Composition-based stats. Identities = 70/314 (22%), Positives = 123/314 (39%), Gaps = 39/314 (12%) Query: 183 KNTFRQYRVLGKGGFGEVCACQV-RATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 + +G+G +G+V + + G+ A K++ + + + E +L + Sbjct: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGE-EGMPLSTIREVAVLRHL 68 Query: 242 N---SRFVVSLAYAY-----ETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAA 293 VV L + + L LV ++ DL ++ + + G P Sbjct: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMF 127 Query: 294 EICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMA 353 ++ GL+ LH R+V+RDLKP+NIL+ G I+++D GLA + V T+ Y A Sbjct: 128 QLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRA 187 Query: 354 PEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSER-- 411 PEV+ Y D W++GC+ EM + F+ + ++ ++ EE R Sbjct: 188 PEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 Query: 412 ---------------------FSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 + L + L +PA+R+ SA HP F+ Sbjct: 248 ALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRI-----SAYSALSHPYFQD 302 Query: 451 LNFKRLGAGMLEPP 464 L + PP Sbjct: 303 LERCKENLDSHLPP 316 >3KA0-A nrPDB Length = 320 Score = 251 bits (641), Expect = 7e-67, Method: Composition-based stats. Identities = 67/285 (23%), Positives = 118/285 (41%), Gaps = 24/285 (8%) Query: 178 RQPVTKNTFRQ-YRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 ++ + ++ +VLG G G+V + T + +A K L+ +R+ E Sbjct: 9 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHW----- 63 Query: 237 ILEKVNSRFVVSLAYAYET----KDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYA 292 +V + YE + L +V+ ++GG+L I G F E A Sbjct: 64 --RASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIM 121 Query: 293 AEICCGLEDLHRERIVYRDLKPENILLDD---HGHIRISDLGLAVHVPEGQTIKGRVGTV 349 I ++ LH I +RD+KPEN+L + ++++D G A ++ T Sbjct: 122 KSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTP 181 Query: 350 GYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLV----KEVP 405 Y+APEV+ E+Y S D W+LG ++Y ++ G PF ++ + E P Sbjct: 182 YYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 241 Query: 406 EEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 S + + L LL +P +R+ + E HP + Sbjct: 242 NPEWSEVSEEVKMLIRNLLKTEPTQRM-----TITEFMNHPWIMQ 281 >1V0B-A nrPDB Length = 288 Score = 251 bits (640), Expect = 9e-67, Method: Composition-based stats. Identities = 68/297 (22%), Positives = 130/297 (43%), Gaps = 36/297 (12%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 + +G+G +G V Q G+ +A KK+ ++ + + + E IL+++ Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQNN-YGETFALKKIRLEK-EDEGIPSTTIREISILKELK 58 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 +V L TK L LV ++ DLK + + + G A + ++ G+ Sbjct: 59 HSNIVKLYDVIHTKKRLVLVFEHLDQ-DLKKLL-DVCEGGLESVTAKSFLLQLLNGIAYC 116 Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKN-E 360 H R+++RDLKP+N+L++ G ++I+D GLA + V T+ Y AP+V+ + Sbjct: 117 HDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSK 176 Query: 361 RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFS------- 413 +Y+ + D W++GC+ EM+ G F + + + R++ + + Sbjct: 177 KYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDP 236 Query: 414 ------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 L S++L DP +R+ +A++ EH FK+ N Sbjct: 237 NFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRI-----TAKQALEHAYFKENN 288 >3HKO-A nrPDB Length = 345 Score = 249 bits (636), Expect = 2e-66, Method: Composition-based stats. Identities = 77/339 (22%), Positives = 125/339 (36%), Gaps = 61/339 (17%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI 222 +++YF LE Q + +G+G +G V T + A K + K +I Sbjct: 12 ENLYFQG---GSLLELQ----KKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKI 64 Query: 223 KK--RKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHI----- 275 ++ K E ++++K++ + L YE + +CLV+ L +GG L + Sbjct: 65 RQINPKDVERIKTEVRLMKKLHHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFID 124 Query: 276 -----------------------------YHMGQAGFP----EARAVFYAAEICCGLEDL 302 H + E +I L L Sbjct: 125 DSTGKCAMDVVKTQICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYL 184 Query: 303 HRERIVYRDLKPENILL--DDHGHIRISDLGLAVHVP-----EGQTIKGRVGTVGYMAPE 355 H + I +RD+KPEN L + I++ D GL+ E + + GT ++APE Sbjct: 185 HNQGICHRDIKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPE 244 Query: 356 VVK--NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFS 413 V+ NE Y D W+ G LL+ ++ G PF +V S Sbjct: 245 VLNTTNESYGPKCDAWSAGVLLHLLLMGAVPFPGVNDADTISQVLNKKLCFENPNYNVLS 304 Query: 414 PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 P AR L S LL ++ ER A +HP + + Sbjct: 305 PLARDLLSNLLNRNVDERF-----DAMRALQHPWISQFS 338 >4BBM-A nrPDB Length = 331 Score = 248 bits (633), Expect = 5e-66, Method: Composition-based stats. Identities = 71/329 (21%), Positives = 129/329 (39%), Gaps = 50/329 (15%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI 222 +++YF + ++G+G +G V C+ + TG++ A KK + Sbjct: 17 ENLYFQSM-------------EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESD- 62 Query: 223 KKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG 282 + + +A+ E ++L+++ +V+L + K LV ++ L + G Sbjct: 63 DDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDL--ELFPNG 120 Query: 283 FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV-PEGQT 341 Y +I G+ H I++RD+KPENIL+ G +++ D G A + G+ Sbjct: 121 LDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEV 180 Query: 342 IKGRVGTVGYMAPEVVKNE-RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERL 400 V T Y APE++ + +Y + D WA+GCL+ EM G+ F + + Sbjct: 181 YDDEVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMC 240 Query: 401 V---------------------------KEVPEEYSERFSPQARSLCSQLLCKDPAERLG 433 + +E E + S L + L DP +R Sbjct: 241 LGNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPF 300 Query: 434 CRGGSAREVKEHPLFKKLNFKRLGAGMLE 462 C E+ H F+ F + L+ Sbjct: 301 C-----AELLHHDFFQMDGFAERFSQELQ 324 >4WNO-A nrPDB Length = 287 Score = 248 bits (633), Expect = 5e-66, Method: Composition-based stats. Identities = 75/283 (26%), Positives = 130/283 (45%), Gaps = 26/283 (9%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRAT-GKMYACKKLEKKRIKKRKGEAMALNEKQI 237 + V K F + ++G G F V + RA A K + KK + K + + E +I Sbjct: 13 ETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQ--TLLGKEIKI 70 Query: 238 LEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 L+++ +V+L E +++ LV+ NGGDL +++ M E + +I Sbjct: 71 LKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAM--RTLSEDTIRLFLQQIAG 128 Query: 298 GLEDLHRERIVYRDLKPENILLDDHG---------HIRISDLGLAVHVPEGQTIKGRVGT 348 + LH + I++RDLKP+NILL + ++I+D G A ++ G+ Sbjct: 129 AMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGS 188 Query: 349 VGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKR---EEVERLVKEVP 405 YMAPEV+ ++ Y D W++G ++Y+ + G++PFQ + R E+ + LV +P Sbjct: 189 PMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIP 248 Query: 406 EEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 E S LL ++ +R+ E HP Sbjct: 249 RETSAPLRQLLL----ALLQRNHKDRM-----DFDEFFHHPFL 282 >5AWM-A nrPDB Length = 394 Score = 248 bits (633), Expect = 6e-66, Method: Composition-based stats. Identities = 73/310 (23%), Positives = 122/310 (39%), Gaps = 56/310 (18%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 + R +G G G VCA T + A KKL + + A E ++++ VN + Sbjct: 45 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP-FQNVTHAKRAYREFKLMKLVNHK 103 Query: 245 FVVSLAYAY------ETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 ++ L A+ E + LV+ LM+ ++ + Q R + ++ CG Sbjct: 104 NIIGLLNAFTPQRNLEEFQDVYLVMELMDA-----NLCQVIQMDLDHDRMSYLLYQMLCG 158 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVK 358 ++ LH I++RDLKP NI++ ++I D GLA + V T Y APEV+ Sbjct: 159 IKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVIL 218 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSP---- 414 YT + D W++GC++ EMI G F + ++ + + +R P Sbjct: 219 GMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRN 278 Query: 415 -----------------------------------QARSLCSQLLCKDPAERLGCRGGSA 439 AR+L S++L DP +R+ S Sbjct: 279 YVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRI-----SV 333 Query: 440 REVKEHPLFK 449 E +H Sbjct: 334 DEALKHEYIN 343 >2F9G-A nrPDB Length = 353 Score = 247 bits (632), Expect = 7e-66, Method: Composition-based stats. Identities = 76/337 (22%), Positives = 141/337 (41%), Gaps = 61/337 (18%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 F+ +LG+G +G VC+ + TG++ A KK+E K L E +IL+ Sbjct: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP--FDKPLFALRTLREIKILKHFKHE 69 Query: 245 FVVSLA-----YAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 ++++ ++E + + ++ LM DL I + ++ + + Sbjct: 70 NIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVI---STQMLSDDHIQYFIYQTLRAV 125 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT-----------IKGRVGT 348 + LH +++RDLKP N+L++ + +++ D GLA + E + V T Sbjct: 126 KVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVAT 185 Query: 349 VGYMAPEVVKNE-RYTFSPDWWALGCLLYEMIAGQSPFQQRKKK---------------- 391 Y APEV+ +Y+ + D W+ GC+L E+ + F R + Sbjct: 186 RWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSD 245 Query: 392 -----IKREEVERLVKEVP-------EEYSERFSPQARSLCSQLLCKDPAERLGCRGGSA 439 I+ +K +P E+ R +P+ L ++L DPA+R+ +A Sbjct: 246 NDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRI-----TA 300 Query: 440 REVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKD 476 +E EHP + + EP +P P + + D Sbjct: 301 KEALEHPYLQTYHDPN-----DEPEGEPIPPSFFEFD 332 >2XYN-A nrPDB Length = 292 Score = 247 bits (632), Expect = 7e-66, Method: Composition-based stats. Identities = 59/273 (21%), Positives = 115/273 (42%), Gaps = 18/273 (6%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI 222 +++YF +W+ +ER +T LG G +GEV + A K L++ + Sbjct: 17 ENLYFQSMDKWE-MERTDITMKH-----KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTM 70 Query: 223 KKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG 282 + L E +++++ +V L + +V M G+L ++ + Sbjct: 71 E----VEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREE 126 Query: 283 FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI 342 ++ A +I +E L ++ ++RDL N L+ ++ ++++D GL+ + G T Sbjct: 127 VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMT-GDTY 185 Query: 343 KGRVG---TVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVE 398 G + + APE + ++ D WA G LL+E+ G SP+ + +E Sbjct: 186 TAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLE 245 Query: 399 RLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 + + E E P+ L PA+R Sbjct: 246 KGYRM---EQPEGCPPKVYELMRACWKWSPADR 275 >2HW6-A nrPDB Length = 307 Score = 247 bits (630), Expect = 1e-65, Method: Composition-based stats. Identities = 81/315 (25%), Positives = 129/315 (40%), Gaps = 48/315 (15%) Query: 168 NRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKG 227 L K+ + +T +LG+G + +V GK YA K +EK+ R Sbjct: 3 TDSLPGKFEDMYKLTSE------LLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRS- 55 Query: 228 EAMALNEKQILEKVN-SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEA 286 E + L + ++ ++ L +E LV + GG + HI Q F E Sbjct: 56 --RVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQK--QKHFNER 111 Query: 287 RAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDH---GHIRISDLGLAVHVPEGQT-- 341 A ++ L+ LH + I +RDLKPENIL + ++I D L + + Sbjct: 112 EASRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCT 171 Query: 342 ------IKGRVGTVGYMAPEVV-----KNERYTFSPDWWALGCLLYEMIAGQSPFQQR-- 388 + G+ YMAPEVV + Y D W+LG +LY M++G PF Sbjct: 172 PITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCG 231 Query: 389 -------------KKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCR 435 + E ++ E P++ S +A+ L S+LL +D +RL Sbjct: 232 ADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRL--- 288 Query: 436 GGSAREVKEHPLFKK 450 SA +V +HP + Sbjct: 289 --SAAQVLQHPWVQG 301 >4AU8-A nrPDB Length = 296 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 66/297 (22%), Positives = 122/297 (41%), Gaps = 36/297 (12%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 + + +G+G +G V + R T ++ A K++ + AL E +L+++ Sbjct: 5 SQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD-DDEGVPSSALREICLLKELK 63 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 + +V L + L LV + DLK + + + ++ GL Sbjct: 64 HKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKY-FDSCNGDLDPEIVKSFLFQLLKGLGFC 121 Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKNER 361 H +++RDLKP+N+L++ +G ++++D GLA + V T+ Y P+V+ + Sbjct: 122 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAK 181 Query: 362 -YTFSPDWWALGCLLYEMI-AGQSPFQQRKKKIKREEVERLVKEVPEEYS---------- 409 Y+ S D W+ GC+ E+ AG+ F + + + RL+ EE Sbjct: 182 LYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK 241 Query: 410 ---------------ERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 + + R L LL +P +R+ SA E +HP F Sbjct: 242 PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRI-----SAEEALQHPYFSDF 293 >4BGQ-A nrPDB Length = 304 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 71/298 (23%), Positives = 124/298 (41%), Gaps = 38/298 (12%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 N F V+G+G +G V C+ + T ++ A KK K + + + L E ++L + Sbjct: 10 VMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKF-KDSEENEEVKETTLRELKMLRTL 68 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 +V L A+ + L LV + L+ + G P + Y ++ + Sbjct: 69 KQENIVELKEAFRRRGKLYLVFEYVEKNMLE--LLEEMPNGVPPEKVKSYIYQLIKAIHW 126 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT--IKGRVGTVGYMAPEVVKN 359 H+ IV+RD+KPEN+L+ + +++ D G A ++ EG V T Y +PE++ Sbjct: 127 CHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLG 186 Query: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR-- 417 Y S D W++GC+L E+ GQ F + + +++++ +P E + F R Sbjct: 187 APYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFH 246 Query: 418 --------------------------SLCSQLLCKDPAERLGCRGGSAREVKEHPLFK 449 L LL DPA+R + HP F+ Sbjct: 247 GLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLT-----EQCLNHPTFQ 299 >4MYG-A nrPDB Length = 372 Score = 246 bits (628), Expect = 2e-65, Method: Composition-based stats. Identities = 76/346 (21%), Positives = 142/346 (41%), Gaps = 67/346 (19%) Query: 174 KWLERQPVTKNTFRQYRV------LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKG 227 K +Q V K + + +G G +G VC+ + +G+ A KKL + + Sbjct: 27 KGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRP-FQSEIF 85 Query: 228 EAMALNEKQILEKVNSRFVVSLAYAYETKDAL------CLVLTLMNGGDLKFHIYHMGQA 281 A E +L+ + V+ L + +L LV+ M + + + Sbjct: 86 AKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFM-----QTDLQKIMGM 140 Query: 282 GFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT 341 F E + + ++ GL+ +H +V+RDLKP N+ +++ ++I D GLA H Sbjct: 141 EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH--ADAE 198 Query: 342 IKGRVGTVGYMAPEVVKN-ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVER- 399 + G V T Y APEV+ + Y + D W++GC++ EM+ G++ F+ + + ++ + Sbjct: 199 MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKV 258 Query: 400 -------------------LVKEVPEEYSERF-------SPQARSLCSQLLCKDPAERLG 433 ++ +P+ + F SPQA L ++L D +RL Sbjct: 259 TGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRL- 317 Query: 434 CRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLD 479 +A + HP F+ PF+ + + D Sbjct: 318 ----TAAQALTHPFFE--------------PFRDPEEETEAQQPFD 345 >6DTL-A nrPDB Length = 364 Score = 246 bits (627), Expect = 3e-65, Method: Composition-based stats. Identities = 71/338 (21%), Positives = 132/338 (39%), Gaps = 43/338 (12%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 +GKG +G VC+ T + A KK+ + L E ++L ++ +V++ Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKIA-NAFDNKIDAKRTLREIKLLRHMDHENIVAIRD 96 Query: 252 AYETK-----DALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRER 306 + + + LM+ DL I E ++ +I GL+ +H Sbjct: 97 IIPPPLRNAFNDVYIAYELMDT-DLHQII--RSNQALSEEHCQYFLYQILRGLKYIHSAN 153 Query: 307 IVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER-YTFS 365 +++RDLKP N+LL+ + ++I D GLA E + V T Y APE++ N YT + Sbjct: 154 VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAA 213 Query: 366 PDWWALGCLLYEMIAGQSPFQQRKKKIKREEV-------------------ERLVKEVPE 406 D W++GC+ E++ + F R + + +R ++++P Sbjct: 214 IDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPP 273 Query: 407 -------EYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAG 459 + P A L ++L DP R+ + + HP L+ Sbjct: 274 YPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRI-----TVLDALAHPYLNSLH-DISDEP 327 Query: 460 MLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEPTDQD 497 PF D + + +++ + + P Q Sbjct: 328 ECTIPFNFDFEN-HALSEEQMKELIYREALAFNPEYQQ 364 >3OHT-A nrPDB Length = 389 Score = 246 bits (627), Expect = 3e-65, Method: Composition-based stats. Identities = 72/308 (23%), Positives = 125/308 (40%), Gaps = 47/308 (15%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 V ++ +G G +G VC+ +G A KKL + + E ++L Sbjct: 47 WEVP-ERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRP-FQSIIHAKRTYRELRLL 104 Query: 239 EKVNSRFVVSLAYAY------ETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYA 292 + + V+ L + E + + LV LM G DL + + F Sbjct: 105 KHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLM-GADLNNIVKC---QKLTDDHVQFLI 160 Query: 293 AEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYM 352 +I GL+ +H I++RDLKP N+ +++ ++I D GLA H + + G V T Y Sbjct: 161 YQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD--EMTGYVATRWYR 218 Query: 353 APEVVKN-ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSER 411 APE++ N Y + D W++GC++ E++ G++ F + +++ RL P R Sbjct: 219 APEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASVISR 278 Query: 412 FS---------------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKE 444 P A L ++L D +R+ +A E Sbjct: 279 MPSHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRI-----TASEALA 333 Query: 445 HPLFKKLN 452 HP F + + Sbjct: 334 HPYFSQYH 341 >6QAU-A nrPDB Length = 280 Score = 246 bits (627), Expect = 3e-65, Method: Composition-based stats. Identities = 72/280 (25%), Positives = 125/280 (44%), Gaps = 20/280 (7%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVR-ATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 V + + ++G G F V + R T A K + KK + K + + E +IL+ Sbjct: 8 VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQ--ILLGKEIKILK 65 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 ++ +V+L E +++ LV+ NGGDL ++ G E + +I + Sbjct: 66 ELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKG--TLSEDTIRVFLHQIAAAM 123 Query: 300 EDLHRERIVYRDLKPENILLD---------DHGHIRISDLGLAVHVPEGQTIKGRVGTVG 350 LH + I++RDLKP+NILL I+I+D G A ++ G+ Sbjct: 124 RILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPM 183 Query: 351 YMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE 410 YMAPEV+ ++ Y D W++G ++Y+ + G+ PFQ + R E+ +P Sbjct: 184 YMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPS-IPR 242 Query: 411 RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 SP +L LL ++ +R+ HP ++ Sbjct: 243 ETSPYLANLLLGLLQRNQKDRMDFEA-----FFSHPFLEQ 277 >1JNK-A nrPDB Length = 423 Score = 245 bits (626), Expect = 3e-65, Method: Composition-based stats. Identities = 80/364 (21%), Positives = 140/364 (38%), Gaps = 57/364 (15%) Query: 151 EYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK 210 + +A + S N+F + + ++ + +G G G VCA + Sbjct: 29 DVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDR 88 Query: 211 MYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAY------ETKDALCLVLT 264 A KKL + + + A E +++ VN + ++SL + E + LV+ Sbjct: 89 NVAIKKLSRP-FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVME 147 Query: 265 LMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGH 324 LM+ ++ + Q R + ++ CG++ LH I++RDLKP NI++ Sbjct: 148 LMDA-----NLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCT 202 Query: 325 IRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSP 384 ++I D GLA + V T Y APEV+ Y + D W++GC++ EM+ + Sbjct: 203 LKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKIL 262 Query: 385 FQQRKKKIKREEVERLVKEVPEEYSERFSP------------------------------ 414 F R + +V + E+ ++ P Sbjct: 263 FPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADS 322 Query: 415 --------QARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFK 466 QAR L S++L DPA+R+ S + +HP + PP Sbjct: 323 EHNKLKASQARDLLSKMLVIDPAKRI-----SVDDALQHPYIN--VWYDPAEVEAPPPQI 375 Query: 467 PDPQ 470 D Q Sbjct: 376 YDKQ 379 >2XS0-A nrPDB Length = 386 Score = 245 bits (626), Expect = 4e-65, Method: Composition-based stats. Identities = 75/331 (22%), Positives = 128/331 (38%), Gaps = 57/331 (17%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 ++ + +G G G VCA + A KKL + + + A E +++ VN Sbjct: 26 KRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP-FQNQTHAKRAYRELVLMKCVNH 84 Query: 244 RFVVSLAYAY------ETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 + ++ L + E + +V+ LM+ ++ + Q R + ++ C Sbjct: 85 KNIIGLLNVFTPQKSLEEFQDVYIVMELMDA-----NLCQVIQMELDHERMSYLLYQMLC 139 Query: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVV 357 G++ LH I++RDLKP NI++ ++I D GLA + V T Y APEV+ Sbjct: 140 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPFVVTRYYRAPEVI 199 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSP--- 414 Y + D W++GC++ EMI G F + +V + E+ ++ P Sbjct: 200 LGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVR 259 Query: 415 -----------------------------------QARSLCSQLLCKDPAERLGCRGGSA 439 QAR L S++L D ++R+ S Sbjct: 260 TYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRI-----SV 314 Query: 440 REVKEHPLFKKLNFKRLGAGMLEPPFKPDPQ 470 E +HP + PP PD Q Sbjct: 315 DEALQHPYIN--VWYDPSEAEAPPPKIPDKQ 343 >3E7O-A nrPDB Length = 360 Score = 245 bits (625), Expect = 4e-65, Method: Composition-based stats. Identities = 78/331 (23%), Positives = 127/331 (38%), Gaps = 57/331 (17%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 ++Q + +G G G VCA G A KKL + + + A E +L+ VN Sbjct: 22 KRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP-FQNQTHAKRAYRELVLLKCVNH 80 Query: 244 RFVVSLAYAY------ETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 + ++SL + E + LV+ LM+ ++ + R + ++ C Sbjct: 81 KNIISLLNVFTPQKTLEEFQDVYLVMELMDA-----NLCQVIHMELDHERMSYLLYQMLC 135 Query: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVV 357 G++ LH I++RDLKP NI++ ++I D GLA + V T Y APEV+ Sbjct: 136 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYVVTRYYRAPEVI 195 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKE-------------- 403 Y + D W++GC++ E++ G FQ + +V + Sbjct: 196 LGMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTVR 255 Query: 404 -------------VPEEYSERFSP-----------QARSLCSQLLCKDPAERLGCRGGSA 439 E + + P QAR L S++L DP +R+ S Sbjct: 256 NYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRI-----SV 310 Query: 440 REVKEHPLFKKLNFKRLGAGMLEPPFKPDPQ 470 E HP + PP D Q Sbjct: 311 DEALRHPYIT--VWYDPAEAEAPPPQIYDAQ 339 >4XEY-B nrPDB Length = 408 Score = 244 bits (622), Expect = 1e-64, Method: Composition-based stats. Identities = 62/350 (17%), Positives = 130/350 (37%), Gaps = 25/350 (7%) Query: 126 VTNCTQRLEQGPCKDLFQELTRLTHEYLSVAP------FADYLDSIYFNRFLQWKWLERQ 179 + + + F L L H + +VA + ++ Sbjct: 61 INTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKW 120 Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 + + LG G +GEV + A K L++ ++ L E +++ Sbjct: 121 EMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME----VEEFLKEAAVMK 176 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 ++ +V L + ++ M G+L ++ + ++ A +I + Sbjct: 177 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAM 236 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVG---TVGYMAPEV 356 E L ++ ++RDL N L+ ++ ++++D GL+ + G T G + + APE Sbjct: 237 EYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMT-GDTYTAHAGAKFPIKWTAPES 295 Query: 357 VKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQ 415 + +++ D WA G LL+E+ G SP+ E +E+ + E E + Sbjct: 296 LAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEK---DYRMERPEGCPEK 352 Query: 416 ARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPF 465 L +P++R S E+ H F+ + + + +E Sbjct: 353 VYELMRACWQWNPSDR-----PSFAEI--HQAFETMFQESSISDEVEKEL 395 >3FI2-A nrPDB Length = 353 Score = 244 bits (622), Expect = 1e-64, Method: Composition-based stats. Identities = 72/310 (23%), Positives = 125/310 (40%), Gaps = 55/310 (17%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 ++ + +G G G VCA + A KKL + + + A E +++ VN Sbjct: 24 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP-FQNQTHAKRAYRELVLMKCVNH 82 Query: 244 RFVVSLAYAY------ETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 + ++SL + E + LV+ LM+ ++ + Q R + ++ C Sbjct: 83 KNIISLLNVFTPQKTLEEFQDVYLVMELMDA-----NLCQVIQMELDHERMSYLLYQMLC 137 Query: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVV 357 G++ LH I++RDLKP NI++ ++I D GLA + V T Y APEV+ Sbjct: 138 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVI 197 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSP--- 414 Y + D W++GC++ EM+ + F R + +V + E+ ++ P Sbjct: 198 LGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 257 Query: 415 -----------------------------------QARSLCSQLLCKDPAERLGCRGGSA 439 QAR L S++L DPA+R+ S Sbjct: 258 NYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRI-----SV 312 Query: 440 REVKEHPLFK 449 + +HP Sbjct: 313 DDALQHPYIN 322 >4OLI-A nrPDB Length = 645 Score = 243 bits (621), Expect = 1e-64, Method: Composition-based stats. Identities = 85/395 (21%), Positives = 153/395 (38%), Gaps = 60/395 (15%) Query: 91 EVTPDDKRKACGRQLTQN--FLSHTGPDLIPEVPRQLVTNCTQRLEQGPC-----KDLFQ 143 E+ D + R ++ F P P QL T +Q L P + + + Sbjct: 264 EICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCP-QLATLTSQCLTYEPTQRPSFRTILR 322 Query: 144 ELTRLTH----EYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGE 199 +LTRL + L+V P + D F+ K ++ R LG+G FG+ Sbjct: 323 DLTRLQPHNLADVLTVNPDSPASDPTVFH--------------KRYLKKIRDLGEGHFGK 368 Query: 200 VCAC----QVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYET 255 V TG+M A K L+ + + E IL + ++ E Sbjct: 369 VSLYCYDPTNDGTGEMVAVKALKADC--GPQHRSGWKQEIDILRTLYHEHIIKYKGCCED 426 Query: 256 KDA--LCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLK 313 + L LV+ + G L+ ++ + A+ + +A +IC G+ LH + ++R+L Sbjct: 427 QGEKSLQLVMEYVPLGSLRDYL---PRHSIGLAQLLLFAQQICEGMAYLHSQHYIHRNLA 483 Query: 314 PENILLDDHGHIRISDLGLAVHVPEGQTIKGRV----GTVGYMAPEVVKNERYTFSPDWW 369 N+LLD+ ++I D GLA VPEG V + APE +K ++ ++ D W Sbjct: 484 ARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVW 543 Query: 370 ALGCLLYEMIA-----GQSP--FQQRKKKIKREEVERLVKEVPE-----EYSERFSPQAR 417 + G LYE++ P F + + + + E+ E ++ + Sbjct: 544 SFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVY 603 Query: 418 SLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 L + + R + + P+ K ++ Sbjct: 604 HLMKNCWETEASFR-----PTFENLI--PILKTVH 631 Score = 113 bits (284), Expect = 2e-25, Method: Composition-based stats. Identities = 57/312 (18%), Positives = 102/312 (32%), Gaps = 52/312 (16%) Query: 160 DYLDSIYFN------RFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATG---- 209 +++YF R L L V + Q LG+G V ++R G Sbjct: 15 PTTENLYFQGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDP 74 Query: 210 --------------------KMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 K L+ ++ +V+ + + Sbjct: 75 EEGKMDDEDPLVPGRDRGQELRVVLKVLDPS---HHDIALAFYETASLMSQVSHTHLAFV 131 Query: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 +V + G L + + P A + A ++ L L + +V+ Sbjct: 132 HGVCVRGPENIMVTEYVEHGPLDVWLR-RERGHVPMAWKMVVAQQLASALSYLENKNLVH 190 Query: 310 RDLKPENILL-------DDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE-- 360 ++ NILL I++SD G+ + + RV + ++APE + Sbjct: 191 GNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREE---RVERIPWLAPECLPGGAN 247 Query: 361 RYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419 + + D W G L E+ G++P Q R K +R + PQ +L Sbjct: 248 SLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSC-----PQLATL 302 Query: 420 CSQLLCKDPAER 431 SQ L +P +R Sbjct: 303 TSQCLTYEPTQR 314 >6NPU-A nrPDB Length = 298 Score = 243 bits (620), Expect = 2e-64, Method: Composition-based stats. Identities = 58/307 (18%), Positives = 123/307 (40%), Gaps = 22/307 (7%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI 222 +++YF ++ + + LG G +GEV + A K L++ + Sbjct: 8 ENLYFQG---SPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM 64 Query: 223 KKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG 282 + L E +++++ +V L + ++ M G+L ++ + Sbjct: 65 E----VEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQE 120 Query: 283 FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI 342 ++ A +I +E L ++ ++RDL N L+ ++ ++++D GL+ + G T Sbjct: 121 VNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMT-GDTY 179 Query: 343 KGRVG---TVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVE 398 G + + APE + +++ D WA G LL+E+ G SP+ E +E Sbjct: 180 TAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLE 239 Query: 399 RLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGA 458 + + E E + L +P++R S E+ H F+ + + + Sbjct: 240 K---DYRMERPEGCPEKVYELMRACWQWNPSDR-----PSFAEI--HQAFETMFQESSIS 289 Query: 459 GMLEPPF 465 +E Sbjct: 290 DEVEKEL 296 >4QNY-A nrPDB Length = 354 Score = 243 bits (620), Expect = 2e-64, Method: Composition-based stats. Identities = 64/308 (20%), Positives = 128/308 (41%), Gaps = 43/308 (13%) Query: 183 KNTFRQYRVLGKGGFGEVCACQV-RATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 + + R++G G +G V + ++ ++ A K++ K+ ++ L E ++L Sbjct: 19 DDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHF 78 Query: 242 NSRFVVSLAYAY-----ETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 N ++ L E D +V+ +M DLK + EA F+ + Sbjct: 79 NDDNIIGLRNILTPEDPENFDHFYIVMDIMET-DLKQVL--RSGQELTEAHIQFFIYQAL 135 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAV-HVPEGQTIKGRVGTVGYMAPE 355 L +H +++RD+ P NIL++ + ++I D GLA +G+ + V Y APE Sbjct: 136 RALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPE 195 Query: 356 VVKNER-YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERF-- 412 +V ++ Y+ D W +GC+L E++ + FQ + + + +++ ++ EE Sbjct: 196 LVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGS 255 Query: 413 -------------------------SPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPL 447 SP+A L +L +P R+ + + HP Sbjct: 256 SAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRI-----TVLQAMRHPF 310 Query: 448 FKKLNFKR 455 ++L+ Sbjct: 311 LEQLHDDA 318 >2FO0-A nrPDB Length = 495 Score = 242 bits (618), Expect = 3e-64, Method: Composition-based stats. Identities = 61/350 (17%), Positives = 130/350 (37%), Gaps = 25/350 (7%) Query: 126 VTNCTQRLEQGPCKDLFQELTRLTHEYLSVAP------FADYLDSIYFNRFLQWKWLERQ 179 + + + F L L H + +VA + ++ Sbjct: 153 INTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKW 212 Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 + + LG G +GEV + A K L++ ++ L E +++ Sbjct: 213 EMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME----VEEFLKEAAVMK 268 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 ++ +V L + ++ M G+L ++ + ++ A +I + Sbjct: 269 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAM 328 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVG---TVGYMAPEV 356 E L ++ ++R+L N L+ ++ ++++D GL+ + G T G + + APE Sbjct: 329 EYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMT-GDTYTAHAGAKFPIKWTAPES 387 Query: 357 VKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQ 415 + +++ D WA G LL+E+ G SP+ E +E+ + E E + Sbjct: 388 LAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEK---DYRMERPEGCPEK 444 Query: 416 ARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPF 465 L +P++R S E+ H F+ + + + +E Sbjct: 445 VYELMRACWQWNPSDR-----PSFAEI--HQAFETMFQESSISDEVEKEL 487 >4XLV-A nrPDB Length = 328 Score = 242 bits (618), Expect = 3e-64, Method: Composition-based stats. Identities = 78/341 (22%), Positives = 134/341 (39%), Gaps = 46/341 (13%) Query: 136 GPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKG 195 GP LF EYLS + + S+Y + V++ R LG+G Sbjct: 4 GPLGPLF---ASSNPEYLSASDV--FPSSVYVP--------DEWEVSREKITLLRELGQG 50 Query: 196 GFGEVCA--CQVRATGK---MYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLA 250 FG V + G+ A K + + + + E LNE +++ VV L Sbjct: 51 SFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIE--FLNEASVMKGFTCHHVVRLL 108 Query: 251 YAYETKDALCLVLTLMNGGDLKFHIYHM--------GQAGFPEARAVFYAAEICCGLEDL 302 +V+ LM GDLK ++ + G+ + AAEI G+ L Sbjct: 109 GVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYL 168 Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI-KGRVG--TVGYMAPEVVKN 359 + ++ V+RDL N ++ ++I D G+ + E KG G V +MAPE +K+ Sbjct: 169 NAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKD 228 Query: 360 ERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARS 418 +T S D W+ G +L+E+ + + P+Q + + V + + + Sbjct: 229 GVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGY---LDQPDNCPERVTD 285 Query: 419 LCSQLLCKDPAERLGCRGGSAREVKE------HPLFKKLNF 453 L +P R + E+ HP F +++F Sbjct: 286 LMRMCWQFNPNMR-----PTFLEIVNLLKDDLHPSFPEVSF 321 >5EFQ-A nrPDB Length = 347 Score = 241 bits (616), Expect = 4e-64, Method: Composition-based stats. Identities = 71/323 (21%), Positives = 132/323 (40%), Gaps = 52/323 (16%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + F ++G+G +G+V + + TG+M A KK+ +K A+ E +IL ++ Sbjct: 11 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDN-EKEGFPITAIREIKILRQLTH 69 Query: 244 RFVVSLAYAYETKDA----------LCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAA 293 + ++++ K+ LV M+ DL + G F E + Sbjct: 70 QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDH-DLMGLL-ESGLVHFNENHIKSFMR 127 Query: 294 EICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV--PEGQTIKGRVGTVGY 351 ++ GL+ H++ ++RD+K NILL++ G I+++D GLA E + +V T+ Y Sbjct: 128 QLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWY 187 Query: 352 MAPEVVKNE-RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE 410 PE++ E RYT + D W+ GC+L E+ + FQ ++ + E + R+ Sbjct: 188 RPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWP 247 Query: 411 R--------------------------FSPQARSLCSQLLCKDPAERLGCRGGSAREVKE 444 A L +L DP++R +A + + Sbjct: 248 DVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKR-----CTAEQALQ 302 Query: 445 HPLFKKLNFKRLGAGMLEPPFKP 467 + + + PP P Sbjct: 303 CEFLRDV-----EPSKMPPPDLP 320 >4NST-A nrPDB Length = 351 Score = 241 bits (615), Expect = 6e-64, Method: Composition-based stats. Identities = 74/319 (23%), Positives = 129/319 (40%), Gaps = 47/319 (14%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + F ++G+G +G+V + + TG++ A KK+ +K A+ E +IL ++ Sbjct: 13 DKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDN-EKEGFPITAIREIKILRQLIH 71 Query: 244 RFVVSLAYAYETKDA----------LCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAA 293 R VV++ K LV M+ DL + G F E + Sbjct: 72 RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDH-DLMGLL-ESGLVHFSEDHIKSFMK 129 Query: 294 EICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV--PEGQTIKGRVGTVGY 351 ++ GLE H++ ++RD+K NILL++ G I+++D GLA E + +V T+ Y Sbjct: 130 QLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWY 189 Query: 352 MAPEVVKN-ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE 410 PE++ ERYT + D W+ GC+L E+ + FQ + + E + RL Sbjct: 190 RPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWP 249 Query: 411 R--------------------------FSPQARSLCSQLLCKDPAERLGCRGGSAREVKE 444 A L +L DP++R +A + + Sbjct: 250 DVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKR-----CTAEQTLQ 304 Query: 445 HPLFKKLNFKRLGAGMLEP 463 K + ++ L Sbjct: 305 SDFLKDVELSKMAPPDLPH 323 >3PPZ-A nrPDB Length = 309 Score = 241 bits (615), Expect = 8e-64, Method: Composition-based stats. Identities = 69/320 (21%), Positives = 126/320 (39%), Gaps = 28/320 (8%) Query: 157 PFADYL----DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMY 212 P +DY +++YF + + + +G G FG V + + Sbjct: 9 PMSDYDIPTTENLYFQGAMDG---DDMDIPWCDLNIKEKIGAGSFGTVHRAEWHGSD--V 63 Query: 213 ACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLK 272 A K L ++ + L E I++++ +V A L +V ++ G L Sbjct: 64 AVKILMEQDFHAERVNE-FLREVAIMKRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLY 122 Query: 273 FHIYHMG-QAGFPEARAVFYAAEICCGLEDLHRER--IVYRDLKPENILLDDHGHIRISD 329 ++ G + E R + A ++ G+ LH IV+RDLK N+L+D +++ D Sbjct: 123 RLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCD 182 Query: 330 LGLAVHVPEG-QTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQR 388 GL+ + K GT +MAPEV+++E D ++ G +L+E+ Q P+ Sbjct: 183 FGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILWELATLQQPWGNL 242 Query: 389 KKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 V K + E +PQ ++ +P +R + ++ PL Sbjct: 243 NPAQVVAAVGFKCKRL--EIPRNLNPQVAAIIEGCWTNEPWKR--PSFATIMDLLR-PLI 297 Query: 449 KKLNFKRLGAGMLEPPFKPD 468 K + PP + D Sbjct: 298 KS---------AVPPPNRSD 308 >3BGP-A nrPDB Length = 333 Score = 240 bits (613), Expect = 1e-63, Method: Composition-based stats. Identities = 85/339 (25%), Positives = 143/339 (42%), Gaps = 35/339 (10%) Query: 141 LFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEV 200 L ++ L H L AP D ++ + K E++P+ ++ +LG GGFG V Sbjct: 22 LLSKINSLAH--LRAAPCND----LHATKLAPGK--EKEPLESQ-YQVGPLLGSGGFGSV 72 Query: 201 CACQVRATGKMYACKKLEKKRIKKRKG---EAMALNEKQILEKVNSRF--VVSLAYAYET 255 + + A K +EK RI E +L+KV+S F V+ L +E Sbjct: 73 YSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFER 132 Query: 256 KDALCLVLTLMNG-GDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKP 314 D+ L+L DL I G E A + ++ + H +++RD+K Sbjct: 133 PDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKD 190 Query: 315 ENILLD-DHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERY-TFSPDWWALG 372 ENIL+D + G +++ D G + + GT Y PE ++ RY S W+LG Sbjct: 191 ENILIDLNRGELKLIDFGSGALLKDT-VYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLG 249 Query: 373 CLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERL 432 LLY+M+ G PF+ ++ I+ + R +R S + + L L P++R Sbjct: 250 ILLYDMVCGDIPFEHDEEIIRGQVFFR----------QRVSSECQHLIRWCLALRPSDR- 298 Query: 433 GCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQA 471 + E++ HP + + + A + P P Sbjct: 299 ----PTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK 333 >1TKI-A nrPDB Length = 321 Score = 239 bits (611), Expect = 2e-63, Method: Composition-based stats. Identities = 67/269 (24%), Positives = 119/269 (44%), Gaps = 12/269 (4%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + LG+G FG V C ++ K Y K ++ K + + E IL Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGT----DQVLVKKEISILNIARH 60 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 R ++ L ++E+ + L ++ ++G D+ I + E V Y ++C L+ LH Sbjct: 61 RNILHLHESFESMEELVMIFEFISGLDIFERI-NTSAFELNEREIVSYVHQVCEALQFLH 119 Query: 304 RERIVYRDLKPENILLDDH--GHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER 361 I + D++PENI+ I+I + G A + G + Y APEV +++ Sbjct: 120 SHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQHDV 179 Query: 362 YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCS 421 + + D W+LG L+Y +++G +PF + E + EE + S +A Sbjct: 180 VSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVD 239 Query: 422 QLLCKDPAERLGCRGGSAREVKEHPLFKK 450 +LL K+ R+ +A E +HP K+ Sbjct: 240 RLLVKERKSRM-----TASEALQHPWLKQ 263 >3GC9-A nrPDB Length = 370 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 71/308 (23%), Positives = 123/308 (39%), Gaps = 47/308 (15%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 V + + R +G G +G VC+ + A KKL + + E ++L Sbjct: 24 WEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP-FQSLIHARRTYRELRLL 81 Query: 239 EKVNSRFVVSLAYAY------ETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYA 292 + + V+ L + E + LV TLM G DL + + F Sbjct: 82 KHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKS---QALSDEHVQFLV 137 Query: 293 AEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYM 352 ++ GL+ +H I++RDLKP N+ +++ +RI D GLA E + G V T Y Sbjct: 138 YQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADE--EMTGYVATRWYR 195 Query: 353 APEVVKN-ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSER 411 APE++ N Y + D W++GC++ E++ G++ F + + + +V E + Sbjct: 196 APEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAK 255 Query: 412 FSPQ---------------------------ARSLCSQLLCKDPAERLGCRGGSAREVKE 444 S + A L ++L D +R+ SA E Sbjct: 256 ISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRV-----SAAEALA 310 Query: 445 HPLFKKLN 452 H F + + Sbjct: 311 HAYFSQYH 318 >5TUR-A nrPDB Length = 404 Score = 239 bits (609), Expect = 4e-63, Method: Composition-based stats. Identities = 88/349 (25%), Positives = 146/349 (41%), Gaps = 41/349 (11%) Query: 137 PCKD------LFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYR 190 PC D L ++ L H L AP D ++ + K E++P+ ++ Sbjct: 83 PCADILEVGMLLSKINSLAH--LRAAPCND----LHATKLAPGK--EKEPLESQ-YQVGP 133 Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKG---EAMALNEKQILEKVNSRF-- 245 +LG GGFG V + + A K +EK RI E +L+KV+S F Sbjct: 134 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 193 Query: 246 VVSLAYAYETKDALCLVLTLMNG-GDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 V+ L +E D+ L+L DL I G E A + ++ + H Sbjct: 194 VIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVLEAVRHCHN 251 Query: 305 ERIVYRDLKPENILLD-DHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERY- 362 +++RD+K ENIL+D + G +++ D G + + GT Y PE ++ RY Sbjct: 252 CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT-VYTDFDGTRVYSPPEWIRYHRYH 310 Query: 363 TFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQ 422 S W+LG LLY+M+ G PF+ ++ I+ + R +R S + + L Sbjct: 311 GRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR----------QRVSSECQHLIRW 360 Query: 423 LLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQA 471 L P++R + E++ HP + + + A + P P Sbjct: 361 CLALRPSDR-----PTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK 404 >1U5R-A nrPDB Length = 348 Score = 238 bits (608), Expect = 4e-63, Method: Composition-based stats. Identities = 58/269 (21%), Positives = 100/269 (37%), Gaps = 15/269 (5%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 + F R +G G FG V + ++ A KK+ + + + E + L+K+ Sbjct: 52 PEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKL 111 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 + Y + LV+ G + + + E GL Sbjct: 112 RHPNTIQYRGCYLREHTAWLVMEYCLGS--ASDLLEVHKKPLQEVEIAAVTHGALQGLAY 169 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVK--- 358 LH +++RD+K NILL + G +++ D G A + VGT +MAPEV+ Sbjct: 170 LHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN---SFVGTPYWMAPEVILAMD 226 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARS 418 +Y D W+LG E+ + P + + E P S +S R+ Sbjct: 227 EGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQ--NESPALQSGHWSEYFRN 284 Query: 419 LCSQLLCKDPAERLGCRGGSAREVKEHPL 447 L K P +R ++ + +H Sbjct: 285 FVDSCLQKIPQDR-----PTSEVLLKHRF 308 >2GCD-A nrPDB Length = 309 Score = 237 bits (605), Expect = 9e-63, Method: Composition-based stats. Identities = 58/269 (21%), Positives = 100/269 (37%), Gaps = 15/269 (5%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 + F R +G G FG V + ++ A KK+ + + + E + L+K+ Sbjct: 13 PEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKL 72 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 + Y + LV+ G + + + E GL Sbjct: 73 RHPNTIQYRGCYLREHTAWLVMEYCLGS--ASDLLEVHKKPLQEVEIAAVTHGALQGLAY 130 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVK--- 358 LH +++RD+K NILL + G +++ D G A + VGT +MAPEV+ Sbjct: 131 LHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN---SFVGTPYWMAPEVILAMD 187 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARS 418 +Y D W+LG E+ + P + + E P S +S R+ Sbjct: 188 EGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQ--NESPALQSGHWSEYFRN 245 Query: 419 LCSQLLCKDPAERLGCRGGSAREVKEHPL 447 L K P +R ++ + +H Sbjct: 246 FVDSCLQKIPQDR-----PTSEVLLKHRF 269 >6CKI-A nrPDB Length = 316 Score = 237 bits (604), Expect = 1e-62, Method: Composition-based stats. Identities = 83/301 (27%), Positives = 130/301 (43%), Gaps = 43/301 (14%) Query: 183 KNTFRQYR-VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 ++ ++ VLG+G V C T + YA K +EK+ R E ++L + Sbjct: 11 EDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRS---RVFREVEMLYQC 67 Query: 242 N-SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 R V+ L +E +D LV M GG + HI+ + F E A ++ L+ Sbjct: 68 QGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHK--RRHFNELEASVVVQDVASALD 125 Query: 301 DLHRERIVYRDLKPENILLDDHGH---IRISDLGLAVHVP--------EGQTIKGRVGTV 349 LH + I +RDLKPENIL + ++I D GL + + G+ Sbjct: 126 FLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSA 185 Query: 350 GYMAPEVV-----KNERYTFSPDWWALGCLLYEMIAGQSPFQQR---------------K 389 YMAPEVV + Y D W+LG +LY +++G PF R Sbjct: 186 EYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPAC 245 Query: 390 KKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFK 449 + + E ++ E P++ S A+ L S+LL +D +RL SA +V +HP + Sbjct: 246 QNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRL-----SAAQVLQHPWVQ 300 Query: 450 K 450 Sbjct: 301 G 301 >3ZDU-A nrPDB Length = 325 Score = 237 bits (604), Expect = 1e-62, Method: Composition-based stats. Identities = 67/296 (22%), Positives = 117/296 (39%), Gaps = 38/296 (12%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 + + +G+G +G V C+ + TG++ A K ++ ++ +A+ E + L++ Sbjct: 1 SMEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYER--PEQSVNKIAMREIKFLKQF 58 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 + +V+L + K + LV ++ + + H G R Y +I ++ Sbjct: 59 HHENLVNLIEVFRQKKKIHLVFEFIDH-TVLDELQHYCH-GLESKRLRKYLFQILRAIDY 116 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV-PEGQTIKGRVGTVGYMAPE-VVKN 359 LH I++RD+KPENIL+ G ++ D G A + G V T Y APE V+K+ Sbjct: 117 LHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKD 176 Query: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR-- 417 Y D WALGC++ EM G ++ V + FS Sbjct: 177 TSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFA 236 Query: 418 -------------------------SLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 + L DPA+R+ S+ ++ H F Sbjct: 237 GVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRI-----SSSDLLHHEYF 287 >4AN9-A nrPDB Length = 301 Score = 236 bits (603), Expect = 2e-62, Method: Composition-based stats. Identities = 70/279 (25%), Positives = 130/279 (46%), Gaps = 15/279 (5%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 + + F + LG G G V + +G + A K + + K + E Q+L Sbjct: 5 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLH 62 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 + NS ++V A+ + + + + M+GG L + G+ PE + + GL Sbjct: 63 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGL 120 Query: 300 EDL-HRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVK 358 L + +I++RD+KP NIL++ G I++ D G++ + + + VGT YM+PE ++ Sbjct: 121 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID-EMANEFVGTRSYMSPERLQ 179 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE-RFSPQAR 417 Y+ D W++G L EM G+ P R E ++ +V E P + FS + + Sbjct: 180 GTHYSVQSDIWSMGLSLVEMAVGRYP---RPPMAIFELLDYIVNEPPPKLPSAVFSLEFQ 236 Query: 418 SLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRL 456 ++ L K+PAER +++ H K+ + + + Sbjct: 237 DFVNKCLIKNPAER-----ADLKQLMVHAFIKRSDAEEV 270 >5G6V-A nrPDB Length = 324 Score = 236 bits (603), Expect = 2e-62, Method: Composition-based stats. Identities = 65/297 (21%), Positives = 128/297 (43%), Gaps = 37/297 (12%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 T+ + LG+G + V + + T + A K++ + + A+ E +L+ + Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLE--HEEGAPCTAIREVSLLKDLK 58 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 +V+L T+ +L LV ++ DLK ++ G + ++ GL Sbjct: 59 HANIVTLHDIIHTEKSLTLVFEYLDK-DLKQYLDDCGNI-INMHNVKLFLFQLLRGLAYC 116 Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKNE- 360 HR+++++RDLKP+N+L+++ G ++++D GLA +T V T+ Y P+++ Sbjct: 117 HRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGST 176 Query: 361 RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERF--SPQAR- 417 Y+ D W +GC+ YEM G+ F + + + R++ EE + + + Sbjct: 177 DYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKT 236 Query: 418 -----------------------SLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 L ++LL + R+ SA + +HP F L Sbjct: 237 YNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRI-----SAEDAMKHPFFLSL 288 >2H8H-A nrPDB Length = 535 Score = 236 bits (602), Expect = 2e-62, Method: Composition-based stats. Identities = 64/258 (24%), Positives = 112/258 (43%), Gaps = 12/258 (4%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 + + + + R LG+G FGEV T + A K L+ + L E Q Sbjct: 260 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEA----FLQEAQ 314 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 +++K+ +V L YA +++ + +V M+ G L + + V AA+I Sbjct: 315 VMKKLRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIA 373 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI--KGRVGTVGYMAP 354 G+ + R V+RDL+ NIL+ ++ +++D GLA + + + +G + + AP Sbjct: 374 SGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAP 433 Query: 355 EVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFS 413 E R+T D W+ G LL E+ G+ P+ + ++VER + Sbjct: 434 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM---PCPPECP 490 Query: 414 PQARSLCSQLLCKDPAER 431 L Q K+P ER Sbjct: 491 ESLHDLMCQCWRKEPEER 508 >6F3F-A nrPDB Length = 455 Score = 236 bits (601), Expect = 3e-62, Method: Composition-based stats. Identities = 64/258 (24%), Positives = 112/258 (43%), Gaps = 12/258 (4%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 + + + + R LG+G FGEV T + A K L+ + L E Q Sbjct: 180 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEA----FLQEAQ 234 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 +++K+ +V L YA +++ + +V MN G L + + V +A+I Sbjct: 235 VMKKLRHEKLVQL-YAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIA 293 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI--KGRVGTVGYMAP 354 G+ + R V+RDL+ NIL+ ++ +++D GLA + + + +G + + AP Sbjct: 294 SGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAP 353 Query: 355 EVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFS 413 E R+T D W+ G LL E+ G+ P+ + ++VER + Sbjct: 354 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM---PCPPECP 410 Query: 414 PQARSLCSQLLCKDPAER 431 L Q K+P ER Sbjct: 411 ESLHDLMCQCWRKEPEER 428 >4EBW-A nrPDB Length = 304 Score = 235 bits (600), Expect = 4e-62, Method: Composition-based stats. Identities = 56/278 (20%), Positives = 114/278 (41%), Gaps = 14/278 (5%) Query: 160 DYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKM---YACKK 216 +++YF + + + + R +G+G FG+V + A K Sbjct: 15 PTTENLYFQGAMGSSTRD-YEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKT 73 Query: 217 LEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIY 276 + + L E + + + +V L T++ + +++ L G+L+ + Sbjct: 74 CKNCTSDSVR--EKFLQEALTMRQFDHPHIVKLIGVI-TENPVWIIMELCTLGELRSFL- 129 Query: 277 HMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV 336 + + A + YA ++ L L +R V+RD+ N+L+ + +++ D GL+ ++ Sbjct: 130 QVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYM 189 Query: 337 PEGQTIKGRVG--TVGYMAPEVVKNERYTFSPDWWALGCLLYEMI-AGQSPFQQRKKKIK 393 + K G + +MAPE + R+T + D W G ++E++ G PFQ K Sbjct: 190 EDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDV 249 Query: 394 REEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 +E + P SL ++ DP+ R Sbjct: 250 IGRIENGER---LPMPPNCPPTLYSLMTKCWAYDPSRR 284 >5Z33-A nrPDB Length = 425 Score = 235 bits (599), Expect = 4e-62, Method: Composition-based stats. Identities = 80/366 (21%), Positives = 141/366 (38%), Gaps = 60/366 (16%) Query: 173 WKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMAL 232 +K + + + + LG+G +G VCA T + A KK+ K+ AL Sbjct: 20 FKVFNQDFIVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKV-TNVFSKKILAKRAL 78 Query: 233 NEKQILEKVN-SRFVVSLAYA----YETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEAR 287 E ++L+ R + L + + L LM DL I +A Sbjct: 79 REIKLLQHFRGHRNITCLYDMDIPRPDNFNETYLYEELMEC-DLAAII--RSGQPLTDAH 135 Query: 288 AVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEG-----QTI 342 + +I CGL+ +H +++RDLKP N+L++ ++I D GLA + Sbjct: 136 FQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYM 195 Query: 343 KGRVGTVGYMAPEV-VKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLV 401 V T Y APE+ + + YT + D W++GC+L E++ G+ F+ R + ++ ++ Sbjct: 196 TEYVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHIL 255 Query: 402 KEVPEEYSERF---------------------------SPQARSLCSQLLCKDPAERLGC 434 EE R +P A L ++L DP+ R+ Sbjct: 256 GTPNEETLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRI-- 313 Query: 435 RGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEPT 494 S + EHP + +PD + D +E ++ + L Sbjct: 314 ---SVEQALEHPYL---------HIWHDASDEPDCPTTFNFDFEVVEDVGEMRKMIL--- 358 Query: 495 DQDFYQ 500 + Y+ Sbjct: 359 -DEVYR 363 >4U41-A nrPDB Length = 332 Score = 234 bits (597), Expect = 8e-62, Method: Composition-based stats. Identities = 63/278 (22%), Positives = 114/278 (41%), Gaps = 24/278 (8%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV-NSR 244 F V+G G +G+V + TG++ A K ++ E E +L+K + R Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE----DEEEEIKLEINMLKKYSHHR 81 Query: 245 FVVSLAYAYETK------DALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 + + A+ K D L LV+ G + + + E + + EI G Sbjct: 82 NIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRG 141 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEG-QTIKGRVGTVGYMAPEVV 357 L LH +++RD+K +N+LL ++ +++ D G++ + +GT +MAPEV+ Sbjct: 142 LAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVI 201 Query: 358 K-----NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERF 412 + Y + D W+ G EM G P + R P S+++ Sbjct: 202 ACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPR--NPPPRLKSKKW 259 Query: 413 SPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 S + S L K+ +R S ++ +HP + Sbjct: 260 SKKFFSFIEGCLVKNYMQR-----PSTEQLLKHPFIRD 292 >6E2O-A nrPDB Length = 295 Score = 234 bits (596), Expect = 1e-61, Method: Composition-based stats. Identities = 63/259 (24%), Positives = 115/259 (44%), Gaps = 9/259 (3%) Query: 191 VLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLA 250 VLGKG +G V A + + A K++ ++ + E + + + + +V Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEIPER---DSRYSQPLHEEIALHKHLKHKNIVQYL 85 Query: 251 YAYETKDALCLVLTLMNGGDLKFHIY-HMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 ++ + + + + GG L + G E FY +I GL+ LH +IV+ Sbjct: 86 GSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVH 145 Query: 310 RDLKPENILLDD-HGHIRISDLGLAVHVPEGQTIK-GRVGTVGYMAPEVVKNER--YTFS 365 RD+K +N+L++ G ++ISD G + + GT+ YMAPE++ Y + Sbjct: 146 RDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKA 205 Query: 366 PDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLC 425 D W+LGC + EM G+ PF + + + + + +V E E S +A++ + Sbjct: 206 ADIWSLGCTIIEMATGKPPFYELGEP-QAAMFKVGMFKVHPEIPESMSAEAKAFILKCFE 264 Query: 426 KDPAERLGCRGGSAREVKE 444 DP +R E + Sbjct: 265 PDPDKRACANDLLVDEFLK 283 >1UA2-A nrPDB Length = 346 Score = 234 bits (596), Expect = 1e-61, Method: Composition-based stats. Identities = 71/296 (23%), Positives = 119/296 (40%), Gaps = 37/296 (12%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLE--KKRIKKRKGEAMALNEKQILEKV 241 + + LG+G F V + + T ++ A KK++ + K AL E ++L+++ Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 + ++ L A+ K + LV M DL I + Y GLE Sbjct: 70 SHPNIIGLLDAFGHKSNISLVFDFMET-DL-EVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV-PEGQTIKGRVGTVGYMAPEVVKNE 360 LH+ I++RDLKP N+LLD++G ++++D GLA + +V T Y APE++ Sbjct: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187 Query: 361 R-YTFSPDWWALGCLLYEMIAGQSPF-QQRKKKIKREEVERLVKEVPEEYSER------- 411 R Y D WA+GC+L E++ + PF + + + EE Sbjct: 188 RMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY 246 Query: 412 --------------FS---PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 FS L L +P R+ +A + + F Sbjct: 247 VTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARI-----TATQALKMKYFSN 297 >5H2U-A nrPDB Length = 267 Score = 232 bits (593), Expect = 2e-61, Method: Composition-based stats. Identities = 58/255 (22%), Positives = 104/255 (40%), Gaps = 9/255 (3%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 + F R LG G FGEV + A K + + + ++ M +E Q + Sbjct: 1 MERPREEFTLCRKLGSGYFGEVFEGLWK-DRVQVAIKVISRDNLLHQQ---MLQSEIQAM 56 Query: 239 EKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 +K+ + +++L D + ++ LM G L + + P + + A ++ G Sbjct: 57 KKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEG 116 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVG-YMAPEVV 357 + L + ++RDL NIL+ ++ ++ D GLA + E + + APE + Sbjct: 117 MCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEAL 176 Query: 358 KNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQA 416 Y+ D W+ G LL+EM + GQ P+ V+ +P P Sbjct: 177 SRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAG-YRMPCPL--ECPPSV 233 Query: 417 RSLCSQLLCKDPAER 431 L C+DP +R Sbjct: 234 HKLMLTCWCRDPEQR 248 >6CQF-A nrPDB Length = 297 Score = 232 bits (593), Expect = 3e-61, Method: Composition-based stats. Identities = 59/269 (21%), Positives = 111/269 (41%), Gaps = 15/269 (5%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 ++ + + LG G +GEV + + +G + A K ++ ++ + E IL+ Sbjct: 14 PRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVK---MEPDDDVSTLQKEILILKTC 70 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 +V+ +Y L + + G L+ G E + + E+ GL Sbjct: 71 RHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTG--SLSELQISYVCREVLQGLAY 128 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIK-GRVGTVGYMAPE---VV 357 LH ++ ++RD+K NIL++D G +R++D G++ + + +GT +MAPE V Sbjct: 129 LHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVA 188 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE-RFSPQA 416 Y D W+LG E+ Q P + + + P + ++S Sbjct: 189 LKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAF 248 Query: 417 RSLCSQLLCKDPAERLGCRGGSAREVKEH 445 + L K P +R SA ++ H Sbjct: 249 HNFIKVTLTKSPKKR-----PSATKMLSH 272 >3OZ6-A nrPDB Length = 388 Score = 232 bits (591), Expect = 4e-61, Method: Composition-based stats. Identities = 67/338 (19%), Positives = 118/338 (34%), Gaps = 79/338 (23%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV-N 242 + + LGKG +G V R TG++ A KK+ + E IL ++ Sbjct: 9 RKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIF-DAFQNSTDAQRTFREIMILTELSG 67 Query: 243 SRFVVSLAYAYETKDA--LCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 +V+L + + LV M DL I + ++ ++ Sbjct: 68 HENIVNLLNVLRADNDRDVYLVFDYMET-DLHAVIRANI---LEPVHKQYVVYQLIKVIK 123 Query: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV----------------------PE 338 LH +++RD+KP NILL+ H++++D GL+ + Sbjct: 124 YLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDD 183 Query: 339 GQTIKGRVGTVGYMAPEVVKNE-RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEV 397 + V T Y APE++ +YT D W+LGC+L E++ G+ F + E + Sbjct: 184 QPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLERI 243 Query: 398 ERLVKEVPEEYSERF-------------------------------------------SP 414 ++ E E + Sbjct: 244 IGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCNE 303 Query: 415 QARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 +A L +LL +P +R+ SA + +HP + Sbjct: 304 EALDLLDKLLQFNPNKRI-----SANDALKHPFVSIFH 336 >2DQ7-X nrPDB Length = 283 Score = 232 bits (591), Expect = 4e-61, Method: Composition-based stats. Identities = 64/256 (25%), Positives = 108/256 (42%), Gaps = 12/256 (4%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 + + + + + LG G FGEV A K L+ + L E QI+ Sbjct: 4 WEIPRESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMSPE----SFLEEAQIM 58 Query: 239 EKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 +K+ +V L YA +++ + +V MN G L + V AA++ G Sbjct: 59 KKLKHDKLVQL-YAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAG 117 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI--KGRVGTVGYMAPEV 356 + + R ++RDL+ NIL+ + +I+D GLA + + + +G + + APE Sbjct: 118 MAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEA 177 Query: 357 VKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQ 415 R+T D W+ G LL E++ G+ P+ + E+VER + + Sbjct: 178 ALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRM---PCPQDCPIS 234 Query: 416 ARSLCSQLLCKDPAER 431 L KDP ER Sbjct: 235 LHELMIHCWKKDPEER 250 >5SYS-A nrPDB Length = 286 Score = 231 bits (589), Expect = 7e-61, Method: Composition-based stats. Identities = 64/258 (24%), Positives = 111/258 (43%), Gaps = 12/258 (4%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 + + + + R LG+G FGE T + A K L+ + L E Q Sbjct: 11 DAWEIPRESLRLEVKLGQGCFGECWMGTWNGTTR-VAIKTLKPGTMSPEA----FLQEAQ 65 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 +++K+ +V L YA +++ + +V M+ G L + + V AA+I Sbjct: 66 VMKKLRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIA 124 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI--KGRVGTVGYMAP 354 G+ + R V+RDL+ NIL+ ++ +++D GLA + + + +G + + AP Sbjct: 125 SGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAP 184 Query: 355 EVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFS 413 E R+T D W+ G LL E+ G+ P+ + ++VER + Sbjct: 185 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM---PCPPECP 241 Query: 414 PQARSLCSQLLCKDPAER 431 L Q KDP ER Sbjct: 242 ESLHDLMCQCWRKDPEER 259 >3MIA-A nrPDB Length = 351 Score = 231 bits (589), Expect = 7e-61, Method: Composition-based stats. Identities = 72/308 (23%), Positives = 119/308 (38%), Gaps = 50/308 (16%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 + + +G+G FGEV + R TG+ A KK+ + +K AL E +IL+ + Sbjct: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITALREIKILQLLKHE 76 Query: 245 FVVSLAYAYETK--------DALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 VV+L TK ++ LV DL + ++ F + + Sbjct: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVL-VKFTLSEIKRVMQMLL 134 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT-----IKGRVGTVGY 351 GL +HR +I++RD+K N+L+ G ++++D GLA + RV T+ Y Sbjct: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194 Query: 352 MAPEVVKNER-YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE 410 PE++ ER Y D W GC++ EM Q ++ + + +L + E Sbjct: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254 Query: 411 RFS----------------------------PQARSLCSQLLCKDPAERLGCRGGSAREV 442 P A L +LL DPA+R+ + Sbjct: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS-----DDA 309 Query: 443 KEHPLFKK 450 H F Sbjct: 310 LNHDFFWS 317 >2OGV-A nrPDB Length = 317 Score = 231 bits (588), Expect = 8e-61, Method: Composition-based stats. Identities = 61/309 (19%), Positives = 120/309 (38%), Gaps = 26/309 (8%) Query: 152 YLSVAPFADYLDSIY-FNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK 210 + Y + Y F Q + E+ +N + + LG G FG+V GK Sbjct: 5 QVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGK 64 Query: 211 MYACKKLEKKRIKKR---KGEAMALNEKQILEKV-NSRFVVSLAYAYETKDALCLVLTLM 266 A K+ K +K + ++E +I+ + +V+L A + ++ Sbjct: 65 EDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYC 124 Query: 267 NGGDLKFHIYHMGQ--------AGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENIL 318 GDL + + + +++++ G+ L + ++RD+ N+L Sbjct: 125 CYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVL 184 Query: 319 LDDHGHIRISDLGLAVHVPEGQTI---KGRVGTVGYMAPEVVKNERYTFSPDWWALGCLL 375 L + +I D GLA + V +MAPE + + YT D W+ G LL Sbjct: 185 LTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILL 244 Query: 376 YEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSP-QARSLCSQLLCKDPAERLG 433 +E+ + G +P+ + + +LVK+ + F+P S+ +P R Sbjct: 245 WEIFSLGLNPYPG---ILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR-- 299 Query: 434 CRGGSAREV 442 + +++ Sbjct: 300 ---PTFQQI 305 >6CCF-A nrPDB Length = 290 Score = 231 bits (588), Expect = 9e-61, Method: Composition-based stats. Identities = 82/296 (27%), Positives = 129/296 (43%), Gaps = 39/296 (13%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGE--------------- 228 N ++ +GKG +G V + + YA K L KK++ K+ G Sbjct: 5 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 64 Query: 229 --------AMALNEKQILEKVNSRFVVSLAYAYET--KDALCLVLTLMNGGDLKFHIYHM 278 E IL+K++ VV L + +D L LV L+ G + Sbjct: 65 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEV---P 121 Query: 279 GQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPE 338 F E +A Y ++ GLE LH ++IV+RD+KP N+LL D GH++I+D G++ Sbjct: 122 CDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEG 181 Query: 339 GQ-TIKGRVGTVGYMAPEVVKNERYTFSP---DWWALGCLLYEMIAGQSPFQQRKKKIKR 394 + GT +MAPE + + +FS D WA G LY + G+ PF Sbjct: 182 NDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALH 241 Query: 395 EEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 +++ PEE S + + L ++L K+P R+G ++K HP K Sbjct: 242 RKIKNEPVVFPEE--PEISEELKDLILKMLDKNPETRIG-----VPDIKLHPWVTK 290 >1JPA-A nrPDB Length = 312 Score = 230 bits (587), Expect = 1e-60, Method: Composition-based stats. Identities = 60/298 (20%), Positives = 123/298 (41%), Gaps = 18/298 (6%) Query: 161 YLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKM---YACKKL 217 ++D F + + + + + +V+G G FGEVC+ ++ GK A K L Sbjct: 10 FIDPFTFEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTL 69 Query: 218 EKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYH 277 + +K++ + L+E I+ + + V+ L + ++ M G L + Sbjct: 70 KSGYTEKQRRD--FLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQ 127 Query: 278 MGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVP 337 F + V I G++ L V+RDL NIL++ + ++SD GL+ + Sbjct: 128 -NDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLE 186 Query: 338 EGQ---TIKGRVG---TVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKK 390 + T +G + + APE ++ ++T + D W+ G +++E+++ G+ P+ Sbjct: 187 DDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTN 246 Query: 391 KIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER--LGCRGGSAREVKEHP 446 + +E+ + P L KD R G + ++ +P Sbjct: 247 QDVINAIEQDYRLPPPM---DCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNP 301 >3BEA-A nrPDB Length = 333 Score = 230 bits (587), Expect = 1e-60, Method: Composition-based stats. Identities = 61/313 (19%), Positives = 121/313 (38%), Gaps = 30/313 (9%) Query: 152 YLSVAPFADYLDSIY-FNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK 210 + Y + Y F Q + E+ +N + + LG G FG+V GK Sbjct: 13 QVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGK 72 Query: 211 MYACKKLEKKRIKKR---KGEAMALNEKQILEKV-NSRFVVSLAYAYETKDALCLVLTLM 266 A K+ K +K + ++E +I+ + +V+L A + ++ Sbjct: 73 EDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYC 132 Query: 267 NGGDLKFHIYHMGQ------------AGFPEARAVFYAAEICCGLEDLHRERIVYRDLKP 314 GDL + + + + +++++ G+ L + ++RD+ Sbjct: 133 CYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAA 192 Query: 315 ENILLDDHGHIRISDLGLAVHVPEGQTI---KGRVGTVGYMAPEVVKNERYTFSPDWWAL 371 N+LL + +I D GLA + V +MAPE + + YT D W+ Sbjct: 193 RNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSY 252 Query: 372 GCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSP-QARSLCSQLLCKDPA 429 G LL+E+ + G +P+ + + +LVK+ + F+P S+ +P Sbjct: 253 GILLWEIFSLGLNPYPG---ILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPT 309 Query: 430 ERLGCRGGSAREV 442 R + +++ Sbjct: 310 HR-----PTFQQI 317 >3KRL-A nrPDB Length = 335 Score = 230 bits (587), Expect = 1e-60, Method: Composition-based stats. Identities = 64/315 (20%), Positives = 123/315 (39%), Gaps = 32/315 (10%) Query: 152 YLSVAPFADYLDSIY-FNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK 210 + Y + Y F Q + E+ +N + + LG G FG+V GK Sbjct: 13 QVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGK 72 Query: 211 MYACKKLEKKRIKKR---KGEAMALNEKQILEKV-NSRFVVSLAYAYETKDALCLVLTLM 266 A K+ K +K + ++E +I+ + +V+L A + ++ Sbjct: 73 EDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYC 132 Query: 267 NGGDLKFHIYHMGQAGF---------PEARA-----VFYAAEICCGLEDLHRERIVYRDL 312 GDL + G PE + + +++++ G+ L + ++RD+ Sbjct: 133 CYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDV 192 Query: 313 KPENILLDDHGHIRISDLGLAVHVPEGQTI---KGRVGTVGYMAPEVVKNERYTFSPDWW 369 N+LL + +I D GLA + V +MAPE + + YT D W Sbjct: 193 AARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVW 252 Query: 370 ALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSP-QARSLCSQLLCKD 427 + G LL+E+ + G +P+ + + +LVK+ + F+P S+ + Sbjct: 253 SYGILLWEIFSLGLNPYPG---ILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALE 309 Query: 428 PAERLGCRGGSAREV 442 P R + +++ Sbjct: 310 PTHR-----PTFQQI 319 >4RC3-A nrPDB Length = 289 Score = 230 bits (587), Expect = 1e-60, Method: Composition-based stats. Identities = 75/307 (24%), Positives = 130/307 (42%), Gaps = 26/307 (8%) Query: 173 WKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKG---EA 229 ++ + ++ ++ +LG GGFG V + + A K +EK RI Sbjct: 1 GPHMKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT 60 Query: 230 MALNEKQILEKVNSRF--VVSLAYAYETKDALCLVLTLMNG-GDLKFHIYHMGQAGFPEA 286 E +L+KV+S F V+ L +E D+ L+L DL I G E Sbjct: 61 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEE 118 Query: 287 RAVFYAAEICCGLEDLHRERIVYRDLKPENILLD-DHGHIRISDLGLAVHVPEGQTIKGR 345 A + ++ + H +++RD+K ENIL+D + G +++ D G + + Sbjct: 119 LARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT-VYTDF 177 Query: 346 VGTVGYMAPEVVKNERY-TFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEV 404 GT Y PE ++ RY S W+LG LLY+M+ G PF+ ++ I+ + R Sbjct: 178 DGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR----- 232 Query: 405 PEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPP 464 +R S + + L L P++R + E++ HP + + + A + Sbjct: 233 -----QRVSSECQHLIRWCLALRPSDR-----PTFEEIQNHPWMQDVLLPQETAEIHLHS 282 Query: 465 FKPDPQA 471 P P Sbjct: 283 LSPGPSK 289 >4IC8-A nrPDB Length = 442 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 72/323 (22%), Positives = 130/323 (40%), Gaps = 49/323 (15%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 + + +G G +G V + + R TG+ A KK+ L E +IL+ Sbjct: 53 VGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIP-NAFDVVTNAKRTLRELKILKHF 111 Query: 242 NSRFVVSLAYA------YETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEI 295 ++++ Y ++ +VL LM DL I+ ++ ++ Sbjct: 112 KHDNIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIH--SSQPLTLEHVRYFLYQL 168 Query: 296 CCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV-----PEGQTIKGRVGTVG 350 GL+ +H ++++RDLKP N+L++++ ++I D G+A + + V T Sbjct: 169 LRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 228 Query: 351 YMAPE-VVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRK-------------------- 389 Y APE ++ YT + D W++GC+ EM+A + F + Sbjct: 229 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVI 288 Query: 390 KKIKREEVERLVKEVPEEY---SERFSP----QARSLCSQLLCKDPAERLGCRGGSAREV 442 + + E V ++ +P E P QA SL ++L +P+ R+ SA Sbjct: 289 QAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARI-----SAAAA 343 Query: 443 KEHPLFKKLNFKRLGAGMLEPPF 465 HP K + PPF Sbjct: 344 LRHPFLAKYHDPDDEPD-CAPPF 365 >4ZSG-A nrPDB Length = 347 Score = 230 bits (586), Expect = 2e-60, Method: Composition-based stats. Identities = 72/323 (22%), Positives = 130/323 (40%), Gaps = 49/323 (15%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 + + +G G +G V + + R TG+ A KK+ L E +IL+ Sbjct: 5 VGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIP-NAFDVVTNAKRTLRELKILKHF 63 Query: 242 NSRFVVSLAYA------YETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEI 295 ++++ Y ++ +VL LM DL I+ ++ ++ Sbjct: 64 KHDNIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIH--SSQPLTLEHVRYFLYQL 120 Query: 296 CCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV-----PEGQTIKGRVGTVG 350 GL+ +H ++++RDLKP N+L++++ ++I D G+A + + V T Sbjct: 121 LRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 180 Query: 351 YMAPE-VVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRK-------------------- 389 Y APE ++ YT + D W++GC+ EM+A + F + Sbjct: 181 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVI 240 Query: 390 KKIKREEVERLVKEVPEEY---SERFSP----QARSLCSQLLCKDPAERLGCRGGSAREV 442 + + E V ++ +P E P QA SL ++L +P+ R+ SA Sbjct: 241 QAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARI-----SAAAA 295 Query: 443 KEHPLFKKLNFKRLGAGMLEPPF 465 HP K + PPF Sbjct: 296 LRHPFLAKYHDPDDEPD-CAPPF 317 >2W96-B nrPDB Length = 306 Score = 229 bits (585), Expect = 2e-60, Method: Composition-based stats. Identities = 68/297 (22%), Positives = 112/297 (37%), Gaps = 38/297 (12%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN-- 242 + +G G +G V + +G A K + + + E +L ++ Sbjct: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGE-EGLPISTVREVALLRRLEAF 63 Query: 243 -SRFVVSLAYAYETKD-----ALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 VV L T + LV ++ DL+ ++ G P + Sbjct: 64 EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFL 122 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 GL+ LH IV+RDLKPENIL+ G ++++D GLA + V T+ Y APEV Sbjct: 123 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEV 182 Query: 357 VKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSER----- 411 + Y D W++GC+ EM + F + + ++ L+ PE+ R Sbjct: 183 LLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLP 242 Query: 412 ---FSP---------------QARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 F P L ++L +P +R+ SA +H K Sbjct: 243 RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI-----SAFRALQHSYLHK 294 >5AIR-A nrPDB Length = 430 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 86/363 (23%), Positives = 146/363 (40%), Gaps = 75/363 (20%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKK-LEKKRIKKRKGEAMALNEKQILEKVNS 243 ++ +V+G G FG V ++ +G++ A KK L+ KR K E QI+ K++ Sbjct: 65 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN--------RELQIMRKLDH 116 Query: 244 RFVVSLAYAY----ETKDALCL--VLTLMNGGDLKFHI---YHMGQAGFPEARAVFYAAE 294 +V L Y + E KD + L VL + + + + Y + P Y + Sbjct: 117 CNIVRLRYFFYSSGEKKDEVYLNLVLDYVP--ETVYRVARHYSRAKQTLPVIYVKLYMYQ 174 Query: 295 ICCGLEDLHRERIVYRDLKPENILLD-DHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMA 353 + L +H I +RD+KP+N+LLD D +++ D G A + G+ + + Y A Sbjct: 175 LFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRA 234 Query: 354 PEVVKN-ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEE----- 407 PE++ YT S D W+ GC+L E++ GQ F + E+ +++ E Sbjct: 235 PELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM 294 Query: 408 --------------------YSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPL 447 + R P+A +LCS+LL P RL + E H Sbjct: 295 NPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARL-----TPLEACAHSF 349 Query: 448 FKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEPTDQDFYQKFATGSV 507 F +L P+ + +D + F+T Q+ ++ Sbjct: 350 FDELR-------------DPNVKLPNGRDTPALFNFTT----------QELSSNPPLATI 386 Query: 508 PIP 510 IP Sbjct: 387 LIP 389 >3GC0-A nrPDB Length = 329 Score = 229 bits (583), Expect = 3e-60, Method: Composition-based stats. Identities = 61/306 (19%), Positives = 119/306 (38%), Gaps = 42/306 (13%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 + + +R+ LG+G +GEV T + A K++ + ++ A+ E +L+++ Sbjct: 32 SIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEH-EEEGVPGTAIREVSLLKEL 90 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 R ++ L L L+ DLK ++ + ++ G+ Sbjct: 91 QHRNIIELKSVIHHNHRLHLIFEYAEN-DLKKYMDKNPDVSMRV--IKSFLYQLINGVNF 147 Query: 302 LHRERIVYRDLKPENILL-----DDHGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPE 355 H R ++RDLKP+N+LL + ++I D GLA + + T+ Y PE Sbjct: 148 CHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPE 207 Query: 356 VVKN-ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFS- 413 ++ Y+ S D W++ C+ EM+ F + + ++ ++ + + Sbjct: 208 ILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVTA 267 Query: 414 --------PQAR-SLCSQ----------------LLCKDPAERLGCRGGSAREVKEHPLF 448 P+ R + +L DP +R+ SA+ EHP F Sbjct: 268 LPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRI-----SAKNALEHPYF 322 Query: 449 KKLNFK 454 +F Sbjct: 323 SHNDFD 328 >3V5Q-A nrPDB Length = 297 Score = 229 bits (583), Expect = 3e-60, Method: Composition-based stats. Identities = 56/277 (20%), Positives = 104/277 (37%), Gaps = 29/277 (10%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQV-----RATGKMYACKKLEKKRIKKRKGEAMALN 233 Q + + R LG+G FG+V + + A K L+ + RK Sbjct: 10 QHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKD---FQR 66 Query: 234 EKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMG-------------- 279 E ++L + +V D L +V M GDL + G Sbjct: 67 EAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQA 126 Query: 280 QAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEG 339 + ++ + A++I G+ L + V+RDL N L+ + ++I D G++ V Sbjct: 127 KGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYST 186 Query: 340 QTIKGRVGT---VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKRE 395 + T + +M PE + ++T D W+ G +L+E+ G+ P+ Q E Sbjct: 187 DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIE 246 Query: 396 EVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERL 432 + + E + + ++P +RL Sbjct: 247 CITQGRV---LERPRVCPKEVYDVMLGCWQREPQQRL 280 >5NGU-A nrPDB Length = 381 Score = 229 bits (583), Expect = 4e-60, Method: Composition-based stats. Identities = 68/331 (20%), Positives = 124/331 (37%), Gaps = 57/331 (17%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 + +G+G +G VC+ A KK+ + + L E +IL + Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISP--FEHQTYCQRTLREIKILLRFRHE 100 Query: 245 FVVSLAYAY-----ETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 ++ + E + +V LM DL + ++ +I GL Sbjct: 101 NIIGINDIIRAPTIEQMKDVYIVQDLMET-DLYKLLK---TQHLSNDHICYFLYQILRGL 156 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKG----RVGTVGYMAPE 355 + +H +++RDLKP N+LL+ ++I D GLA G V T Y APE Sbjct: 157 KYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPE 216 Query: 356 VVKNER-YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEY------ 408 ++ N + YT S D W++GC+L EM++ + F + + + ++ +E Sbjct: 217 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 276 Query: 409 -----------------SERFSPQAR----SLCSQLLCKDPAERLGCRGGSAREVKEHPL 447 R P A L ++L +P +R+ + HP Sbjct: 277 LKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRI-----EVEQALAHPY 331 Query: 448 FKKLNFKRLGAGMLEPPFKPDPQAIYCKDVL 478 ++ +P +P +A + D+ Sbjct: 332 LEQY---------YDPSDEPIAEAPFKFDME 353 >4GS6-A nrPDB Length = 315 Score = 228 bits (582), Expect = 5e-60, Method: Composition-based stats. Identities = 66/267 (24%), Positives = 113/267 (42%), Gaps = 19/267 (7%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 V+G+G FG VC + RA K A K++ + + E + L +VN Sbjct: 9 KEIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQI-----ESESERKAFIVELRQLSRVNH 61 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGF-PEARAVFYAAEICCGLEDL 302 +V L A + +CLV+ GG L ++ + A A+ + + G+ L Sbjct: 62 PNIVKLYGACL--NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYL 119 Query: 303 HRER---IVYRDLKPENILLDDHGHI-RISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVK 358 H + +++RDLKP N+LL G + +I D G A + + G+ +MAPEV + Sbjct: 120 HSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTH--MTNNKGSAAWMAPEVFE 177 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARS 418 Y+ D ++ G +L+E+I + PF + R P + S Sbjct: 178 GSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRP-PLIKNLPKPIES 236 Query: 419 LCSQLLCKDPAERLGCRGGSAREVKEH 445 L ++ KDP++R ++ H Sbjct: 237 LMTRCWSKDPSQR--PSMEEIVKIMTH 261 >5VO2-A nrPDB Length = 300 Score = 228 bits (582), Expect = 5e-60, Method: Composition-based stats. Identities = 57/269 (21%), Positives = 103/269 (38%), Gaps = 21/269 (7%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 + V + +G G G V + G+ A KK+ + + Sbjct: 5 DLWEVPFEEILDLQWVGSGAQGAVFLGRFH--GEEVAVKKVRDLKETD----------IK 52 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 L K+ +++ C+++ G L + + V ++ I Sbjct: 53 HLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVL--RAGRPVTPSLLVDWSMGIA 110 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 G+ LH +I++RDLK N+L+ ++ISD G + + + T GTV +MAPEV Sbjct: 111 GGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEV 170 Query: 357 VKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQA 416 ++NE + D W+ G +L+E++ G+ P++ V +P Sbjct: 171 IRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLP--VPSSCPDGF 228 Query: 417 RSLCSQLLCKDPAERLGCRGGSAREVKEH 445 + L Q P R S R++ H Sbjct: 229 KILLRQCWNSKPRNR-----PSFRQILLH 252 >3TT0-A nrPDB Length = 382 Score = 228 bits (581), Expect = 6e-60, Method: Composition-based stats. Identities = 64/318 (20%), Positives = 134/318 (42%), Gaps = 44/318 (13%) Query: 160 DYLDSIYFNRFL------QWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK--- 210 +++YF L + R + ++ + LG+G FG+V + K Sbjct: 39 PTTENLYFQGMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKP 98 Query: 211 ----MYACKKLEKKRIKKRKGEAMALNEKQILEKV-NSRFVVSLAYAYETKDALCLVLTL 265 A K L+ +K + ++E ++++ + + +++L A L +++ Sbjct: 99 NRVTKVAVKMLKSDATEKDLSD--LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEY 156 Query: 266 MNGGDLKFHIYHMGQAGF---------PEARA-----VFYAAEICCGLEDLHRERIVYRD 311 + G+L+ ++ G PE + V A ++ G+E L ++ ++RD Sbjct: 157 ASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRD 216 Query: 312 LKPENILLDDHGHIRISDLGLAV---HVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDW 368 L N+L+ + ++I+D GLA H+ + V +MAPE + + YT D Sbjct: 217 LAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDV 276 Query: 369 WALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPE-EYSERFSPQARSLCSQLLCK 426 W+ G LL+E+ G SP+ + EE+ +L+KE + + + + Sbjct: 277 WSFGVLLWEIFTLGGSPYPG----VPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHA 332 Query: 427 DPAERLGCRGGSAREVKE 444 P++R + +++ E Sbjct: 333 VPSQR-----PTFKQLVE 345 >4QTB-A nrPDB Length = 380 Score = 228 bits (581), Expect = 6e-60, Method: Composition-based stats. Identities = 65/305 (21%), Positives = 119/305 (39%), Gaps = 50/305 (16%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 + Q + +G+G +G V + A KK+ + + L E QIL + Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISP--FEHQTYCQRTLREIQILLRFRHE 99 Query: 245 FVVSLAYAY-----ETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 V+ + E + +V LM DL + ++ +I GL Sbjct: 100 NVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLKS---QQLSNDHICYFLYQILRGL 155 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKG----RVGTVGYMAPE 355 + +H +++RDLKP N+L++ ++I D GLA G V T Y APE Sbjct: 156 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE 215 Query: 356 VVKNER-YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEE------- 407 ++ N + YT S D W++GC+L EM++ + F + + + ++ +E Sbjct: 216 IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 275 Query: 408 ---------------------YSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHP 446 + + S +A L ++L +P +R+ + E HP Sbjct: 276 MKARNYLQSLPSKTKVAWAKLFPKSDS-KALDLLDRMLTFNPNKRI-----TVEEALAHP 329 Query: 447 LFKKL 451 ++ Sbjct: 330 YLEQY 334 >2J0K-A nrPDB Length = 656 Score = 227 bits (580), Expect = 8e-60, Method: Composition-based stats. Identities = 59/285 (20%), Positives = 114/285 (40%), Gaps = 13/285 (4%) Query: 153 LSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKM- 211 +SV+ DY + I + + R +G+G FG+V + Sbjct: 359 VSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPA 418 Query: 212 --YACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGG 269 A K + + L E + + + +V L T++ + +++ L G Sbjct: 419 MAVAIKTCKNCTSDSVR--EKFLQEALTMRQFDHPHIVKLIGVI-TENPVWIIMELCTLG 475 Query: 270 DLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISD 329 +L+ + + + A + YA ++ L L +R V+RD+ N+L+ +++ D Sbjct: 476 ELRSFL-QVRKFSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSATDCVKLGD 534 Query: 330 LGLAVHVPEGQTIKGRVG--TVGYMAPEVVKNERYTFSPDWWALGCLLYEMI-AGQSPFQ 386 GL+ ++ + K G + +MAPE + R+T + D W G ++E++ G PFQ Sbjct: 535 FGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQ 594 Query: 387 QRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 K +E + P SL ++ DP+ R Sbjct: 595 GVKNNDVIGRIENGER---LPMPPNCPPTLYSLMTKCWAYDPSRR 636 >2PL0-A nrPDB Length = 289 Score = 227 bits (579), Expect = 9e-60, Method: Composition-based stats. Identities = 59/260 (22%), Positives = 109/260 (41%), Gaps = 12/260 (4%) Query: 175 WLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNE 234 W + V + T + LG G FGEV K A K L++ + L E Sbjct: 14 WEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTK-VAVKSLKQGSMSP----DAFLAE 68 Query: 235 KQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAE 294 +++++ + +V L YA T++ + ++ M G L + + + AA+ Sbjct: 69 ANLMKQLQHQRLVRL-YAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQ 127 Query: 295 ICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI--KGRVGTVGYM 352 I G+ + ++RDL+ NIL+ D +I+D GLA + + + +G + + Sbjct: 128 IAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWT 187 Query: 353 APEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSER 411 APE + +T D W+ G LL E++ G+ P+ + +ER + V + Sbjct: 188 APEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMV---RPDN 244 Query: 412 FSPQARSLCSQLLCKDPAER 431 + L + P +R Sbjct: 245 CPEELYQLMRLCWKERPEDR 264 >5X02-A nrPDB Length = 347 Score = 227 bits (578), Expect = 1e-59, Method: Composition-based stats. Identities = 66/346 (19%), Positives = 132/346 (38%), Gaps = 50/346 (14%) Query: 139 KDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFG 198 K F+ ++L ++ + +Y ++ F ++++ + + +VLG G FG Sbjct: 7 KKQFRYESQLQMVQVTGSSDNEY----FYVDFREYEYDLKWEFPRENLEFGKVLGSGAFG 62 Query: 199 EVCACQV---RATGK--MYACKKLEKKRIKKRKGEAMALNEKQILEKVN-SRFVVSLAYA 252 +V TG A K L++K + ++E +++ ++ +V+L A Sbjct: 63 KVMNATAYGISKTGVSIQVAVKMLKEKADSSER--EALMSELKMMTQLGSHENIVNLLGA 120 Query: 253 YETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVF---------------------- 290 + L+ GDL ++ + F E + Sbjct: 121 CTLSGPIYLIFEYCCYGDLLNYLRS-KREKFSEDEIEYENQKRLEEEEDLNVLTFEDLLC 179 Query: 291 YAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVG--- 347 +A ++ G+E L + V+RDL N+L+ ++I D GLA + R Sbjct: 180 FAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARL 239 Query: 348 TVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPE 406 V +MAPE + YT D W+ G LL+E+ + G +P+ ++ + ++ + Sbjct: 240 PVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQ 299 Query: 407 EYSERFSPQARSLCSQLLCKDPAER---------LGCRGGSAREVK 443 + + + + D +R LGC+ A E Sbjct: 300 PFYA--TEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAM 343 >4AT3-A nrPDB Length = 299 Score = 226 bits (577), Expect = 2e-59, Method: Composition-based stats. Identities = 56/273 (20%), Positives = 103/273 (37%), Gaps = 26/273 (9%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQV-----RATGKMYACKKLEKKRIKKRKGEAMALN 233 Q + ++ R LG+G FG+V + + A K L+ RK Sbjct: 8 QHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKD---FHR 64 Query: 234 EKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQ-----------AG 282 E ++L + +V D L +V M GDL + G Sbjct: 65 EAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTE 124 Query: 283 FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI 342 +++ + A +I G+ L + V+RDL N L+ ++ ++I D G++ V Sbjct: 125 LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYY 184 Query: 343 KGRVGT---VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVE 398 + T + +M PE + ++T D W+LG +L+E+ G+ P+ Q E + Sbjct: 185 RVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECIT 244 Query: 399 RLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 + + + L ++P R Sbjct: 245 QGRV---LQRPRTCPQEVYELMLGCWQREPHMR 274 >4R7H-A nrPDB Length = 343 Score = 226 bits (577), Expect = 2e-59, Method: Composition-based stats. Identities = 61/318 (19%), Positives = 118/318 (37%), Gaps = 34/318 (10%) Query: 152 YLSVAPFADYLDSIY-FNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK 210 + Y + Y F Q + E+ +N + + LG G FG+V GK Sbjct: 17 QVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGK 76 Query: 211 MYACKKLEKKRIKKR---KGEAMALNEKQILEKV-NSRFVVSLAYAYETKDALCLVLTLM 266 A K+ K +K + ++E +I+ + +V+L A + ++ Sbjct: 77 EDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYC 136 Query: 267 NGGDLKFHIYHMGQ---------------------AGFPEARAVFYAAEICCGLEDLHRE 305 GDL + + + +++++ G+ L + Sbjct: 137 TYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASK 196 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI---KGRVGTVGYMAPEVVKNERY 362 ++RD+ N+LL + +I D GLA + V +MAPE + + Y Sbjct: 197 NCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDSVY 256 Query: 363 TFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSP-QARSLC 420 T D W+ G LL+E+ + G +P+ + + +LVK+ + F+P S+ Sbjct: 257 TVQSDVWSYGILLWEIFSLGLNPYPG---ILVNSKFYKLVKDGYQMAQPAFAPKNIYSIM 313 Query: 421 SQLLCKDPAERLGCRGGS 438 +P R + + Sbjct: 314 QACWALEPTHRPTFQQIT 331 >2BRG-A nrPDB Length = 297 Score = 226 bits (576), Expect = 2e-59, Method: Composition-based stats. Identities = 69/271 (25%), Positives = 119/271 (43%), Gaps = 14/271 (5%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + + LG+G +GEV R T + A K ++ KR E I + +N Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKR--AVDCPENIKKEICINKMLNH 64 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 VV + L L +GG+L I G PE A + ++ G+ LH Sbjct: 65 ENVVKFYGHRREGNIQYLFLEYCSGGELFDRIE--PDIGMPEPDAQRFFHQLMAGVVYLH 122 Query: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQ---TIKGRVGTVGYMAPEVVKNE 360 I +RD+KPEN+LLD+ +++ISD GLA + GT+ Y+APE++K Sbjct: 123 GIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRR 182 Query: 361 RYT-FSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419 + D W+ G +L M+AG+ P+ Q + + K ++ +L Sbjct: 183 EFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNP-WKKIDSAPLAL 241 Query: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 ++L ++P+ R+ + ++K+ + K Sbjct: 242 LHKILVENPSARI-----TIPDIKKDRWYNK 267 >3ALO-A nrPDB Length = 327 Score = 225 bits (573), Expect = 4e-59, Method: Composition-based stats. Identities = 62/298 (20%), Positives = 128/298 (42%), Gaps = 19/298 (6%) Query: 171 LQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAM 230 L+ + T + +G+G +G V + +G++ A K++ + + +++ + + Sbjct: 9 LKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRI-RSTVDEKEQKQL 67 Query: 231 ALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGD--LKFHIYHMGQAGFPEARA 288 ++ ++ + ++V A + + + LM+ ++Y + PE Sbjct: 68 LMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEIL 127 Query: 289 VFYAAEICCGLEDLHRE-RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVG 347 L L +I++RD+KP NILLD G+I++ D G++ + + G Sbjct: 128 GKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAG 187 Query: 348 TVGYMAPEVV----KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKE 403 YMAPE + + Y D W+LG LYE+ G+ P+ + +++ ++VK Sbjct: 188 CRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNS--VFDQLTQVVKG 245 Query: 404 VPEEYSE----RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLG 457 P + S FSP + + L KD ++R +E+ +HP + + Sbjct: 246 DPPQLSNSEEREFSPSFINFVNLCLTKDESKR-----PKYKELLKHPFILMYEERAVE 298 >5MJB-A nrPDB Length = 305 Score = 225 bits (573), Expect = 5e-59, Method: Composition-based stats. Identities = 56/272 (20%), Positives = 112/272 (41%), Gaps = 18/272 (6%) Query: 187 RQYRVLGKGGFGEVCACQVRATGK---MYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + V+G G FGEV +++ GK A K L+ +K++ + L+E I+ + + Sbjct: 29 KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRD--FLSEASIMGQFDH 86 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 R ++ L + ++ M L + F + V I G++ L Sbjct: 87 RNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQ-NDGQFTVIQLVGMLRGIAAGMKYLS 145 Query: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQ---TIKGRVG---TVGYMAPEVV 357 V+RDL NIL++ + ++SD GL+ ++ + T +G V + APE + Sbjct: 146 EMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAI 205 Query: 358 KNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQA 416 ++T + D W+ G +++E+++ G+ P+ + +E+ + P Sbjct: 206 AYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPM---DCPAAL 262 Query: 417 RSLCSQLLCKDPAE--RLGCRGGSAREVKEHP 446 L KD R + ++ +P Sbjct: 263 HQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNP 294 >4E93-A nrPDB Length = 377 Score = 225 bits (573), Expect = 5e-59, Method: Composition-based stats. Identities = 63/259 (24%), Positives = 109/259 (42%), Gaps = 10/259 (3%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 ++ + +G+G FGEV + ++RA + A K + +A L E + Sbjct: 107 DKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVK--SCRETLPPDLKAKFLQEAR 164 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 IL++ + +V L K + +V+ L+ GGD + G A + + Sbjct: 165 ILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEG-ARLRVKTLLQMVGDAA 223 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKG---RVGTVGYMA 353 G+E L + ++RDL N L+ + ++ISD G++ +G R V + A Sbjct: 224 AGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTA 283 Query: 354 PEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERF 412 PE + RY+ D W+ G LL+E + G SP+ + RE VE+ + E Sbjct: 284 PEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGR---LPCPELC 340 Query: 413 SPQARSLCSQLLCKDPAER 431 L Q +P +R Sbjct: 341 PDAVFRLMEQCWAYEPGQR 359 >2XNP-A nrPDB Length = 279 Score = 225 bits (573), Expect = 5e-59, Method: Composition-based stats. Identities = 66/275 (24%), Positives = 116/275 (42%), Gaps = 19/275 (6%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + +G G +G + ++ GK+ K+L+ + + M ++E +L ++ Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMT-EAEKQMLVSEVNLLRELKH 64 Query: 244 RFVVSLAYAY--ETKDALCLVLTLMNGGDLKFHIYH--MGQAGFPEARAVFYAAEICCGL 299 +V T L +V+ GGDL I + E + ++ L Sbjct: 65 PNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLAL 124 Query: 300 EDLHR-----ERIVYRDLKPENILLDDHGHIRISDLGLAVHV-PEGQTIKGRVGTVGYMA 353 ++ HR +++RDLKP N+ LD ++++ D GLA + + K VGT YM+ Sbjct: 125 KECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMS 184 Query: 354 PEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFS 413 PE + Y D W+LGCLLYE+ A PF +K ++ R+S Sbjct: 185 PEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFR---RIPYRYS 241 Query: 414 PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 + + +++L R S E+ E+PL Sbjct: 242 DELNEIITRMLNLKDYHR-----PSVEEILENPLI 271 >4O2Z-A nrPDB Length = 377 Score = 224 bits (570), Expect = 1e-58, Method: Composition-based stats. Identities = 60/305 (19%), Positives = 122/305 (40%), Gaps = 43/305 (14%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 + ++LG G +G C+C TG+ + KK + + + L E ++ + Sbjct: 46 KYTLLKILGMGAYGIACSCLDGDTGEKVSIKKC-RDVFRDVEDGKRVLREIDMMRFFHHE 104 Query: 245 FVVS-------LAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 +++ L Y + + + +V LM D+ ++ + E+ ++ +I Sbjct: 105 NLLNVVNILPPLKREYHSFEDVYVVTPLM---DVDMNVVLRSRQVLEESHMQYFVYQILR 161 Query: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEV 356 GL+ LH + +RDLKP N++ + ++I D GL+ V + V T Y PE+ Sbjct: 162 GLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPEL 221 Query: 357 VK-NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSER---- 411 + N Y+ + D W++GC+ EM + F R + + + + + P E Sbjct: 222 LLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEHREAL 281 Query: 412 ---------------------FSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 + + S++ DP++R +A ++ HP Sbjct: 282 EKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKR-----PTAADMLAHPYLAH 336 Query: 451 LNFKR 455 L+ + Sbjct: 337 LHDEE 341 >3DKO-A nrPDB Length = 318 Score = 224 bits (570), Expect = 1e-58, Method: Composition-based stats. Identities = 60/254 (23%), Positives = 109/254 (42%), Gaps = 14/254 (5%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKM---YACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 + RV+G G FGEVC+ +++ GK A K L+ +K++ + L E I+ + + Sbjct: 45 IKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRD--FLCEASIMGQFD 102 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 VV L + +V+ M G L + F + V I G+ L Sbjct: 103 HPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKH-DGQFTVIQLVGMLRGIAAGMRYL 161 Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEG----QTIKGRVGTVGYMAPEVVK 358 V+RDL NIL++ + ++SD GL+ + + T G V + APE ++ Sbjct: 162 ADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQ 221 Query: 359 NERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 ++T + D W+ G +++E+++ G+ P+ + + +E + Sbjct: 222 YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYR---LPAPMDCPAGLH 278 Query: 418 SLCSQLLCKDPAER 431 L K+ AER Sbjct: 279 QLMLDCWQKERAER 292 >4P5Q-A nrPDB Length = 361 Score = 224 bits (570), Expect = 1e-58, Method: Composition-based stats. Identities = 56/255 (21%), Positives = 107/255 (41%), Gaps = 14/255 (5%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKM---YACKKLEKKRIKKRKGEAMALNEKQILEKV 241 +V+G G FGEVC+ +++ K A K L+ +K++ + L E I+ + Sbjct: 34 NISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRD--FLGEASIMGQF 91 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 + ++ L + +V M G L + A F + V I G++ Sbjct: 92 DHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKH-DAQFTVIQLVGMLRGIASGMKY 150 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT--IKGRVG--TVGYMAPEVV 357 L V+RDL NIL++ + ++SD GL+ + + R G + + +PE + Sbjct: 151 LSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAI 210 Query: 358 KNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQA 416 ++T + D W+ G +L+E+++ G+ P+ + + + V+ + P Sbjct: 211 AYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPM---DCPAAL 267 Query: 417 RSLCSQLLCKDPAER 431 L KD R Sbjct: 268 YQLMLDCWQKDRNNR 282 >1K9A-A nrPDB Length = 450 Score = 223 bits (569), Expect = 1e-58, Method: Composition-based stats. Identities = 60/269 (22%), Positives = 107/269 (39%), Gaps = 16/269 (5%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 + + + +GKG FG+V R G A K ++ L E ++ Sbjct: 188 WALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDAT-----AQAFLAEASVM 240 Query: 239 EKVNSRFVVSLAYAY-ETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 ++ +V L E K L +V M G L ++ G++ + ++ ++C Sbjct: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300 Query: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVV 357 +E L V+RDL N+L+ + ++SD GL Q V + APE + Sbjct: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL--PVKWTAPEAL 358 Query: 358 KNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQA 416 + ++++ D W+ G LL+E+ + G+ P+ + K VE+ K + + P Sbjct: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKM---DAPDGCPPAV 415 Query: 417 RSLCSQLLCKDPAERLGCRGGSAREVKEH 445 + D A R RE EH Sbjct: 416 YDVMKNCWHLDAATRPTFLQ--LREQLEH 442 >6GQK-A nrPDB Length = 328 Score = 223 bits (569), Expect = 1e-58, Method: Composition-based stats. Identities = 59/307 (19%), Positives = 113/307 (36%), Gaps = 35/307 (11%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK-----MYACKKL 217 ++ + Q + + +N + LG G FG+V + K A K L Sbjct: 20 NNYSYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKML 79 Query: 218 EKKRIKKRKGEAMALNEKQILEKV-NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIY 276 + ++E ++L + N +V+L A ++ GDL + Sbjct: 80 KPSA--HSTEREALMSELKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLR 137 Query: 277 HMG--------------QAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDH 322 + + ++ ++ G+ L + ++RDL NILL Sbjct: 138 RKRDEFVPYKVAPEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHG 197 Query: 323 GHIRISDLGLAVHVPEGQTIKGRVG---TVGYMAPEVVKNERYTFSPDWWALGCLLYEMI 379 +I D GLA + + V +MAPE + N YTF D W+ G L+E+ Sbjct: 198 NITKICDFGLARDIKNDSNYVDKGNARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELF 257 Query: 380 A-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSP-QARSLCSQLLCKDPAERLGCRGG 437 + G SP+ + +++KE S ++P + + DP +R Sbjct: 258 SLGSSPYPGMP---VDSKFYKMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKR-----P 309 Query: 438 SAREVKE 444 + +++ + Sbjct: 310 TFKQIVQ 316 >3A4O-X nrPDB Length = 286 Score = 223 bits (569), Expect = 1e-58, Method: Composition-based stats. Identities = 50/258 (19%), Positives = 105/258 (40%), Gaps = 11/258 (4%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 + + + + + + LG G FGEV + K A K L+ + L E Sbjct: 6 DAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTK-VAVKTLKPGTMS----VQAFLEEAN 60 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 +++ + +V L ++ + ++ M G L + + + ++A+I Sbjct: 61 LMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIA 120 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI--KGRVGTVGYMAP 354 G+ + R+ ++RDL+ N+L+ + +I+D GLA + + + +G + + AP Sbjct: 121 EGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAP 180 Query: 355 EVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFS 413 E + +T D W+ G LLYE++ G+ P+ R + + + E Sbjct: 181 EAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRM---PRVENCP 237 Query: 414 PQARSLCSQLLCKDPAER 431 + + + ER Sbjct: 238 DELYDIMKMCWKEKAEER 255 >5GRN-A nrPDB Length = 356 Score = 223 bits (569), Expect = 2e-58, Method: Composition-based stats. Identities = 62/339 (18%), Positives = 119/339 (35%), Gaps = 51/339 (15%) Query: 127 TNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTF 186 Q+ + + ++ HEY+ V P +Q + R ++ Sbjct: 2 AMDKQKPRYEIRWRVIESISPDGHEYIYVDP-------------MQLPYDSRWEFPRDGL 48 Query: 187 RQYRVLGKGGFGEVCACQVRATGK-----MYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 RVLG G FG+V + A K L+ K ++E +I+ + Sbjct: 49 VLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEK--QALMSELKIMTHL 106 Query: 242 N-SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQ-------------------- 280 +V+L A + ++ GDL +++ Sbjct: 107 GPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLS 166 Query: 281 ----AGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV 336 G + + ++ G+E L + V+RDL N+LL ++I D GLA + Sbjct: 167 DDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDI 226 Query: 337 PEGQTIKGRVGT---VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKI 392 + T V +MAPE + + YT D W+ G LL+E+ + G +P+ Sbjct: 227 MHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDS 286 Query: 393 KREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 + + + + + + + + +P +R Sbjct: 287 TFYNKIKSGYRMAK--PDHATSEVYEIMVKCWNSEPEKR 323 >4E7W-A nrPDB Length = 394 Score = 223 bits (568), Expect = 2e-58, Method: Composition-based stats. Identities = 80/317 (25%), Positives = 128/317 (40%), Gaps = 51/317 (16%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKK-LEKKRIKKRKGEAMALNEKQILEKVNSR 244 + +V+G G FG V ++ + + A KK L+ KR K E QI+ V Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFKN--------RELQIMRIVKHP 92 Query: 245 FVVSLAYAYETKDA------LCLVLTLMNGGDLK-FHIYHMGQAGFPEARAVFYAAEICC 297 VV L + + L LVL + + Y + P Y ++ Sbjct: 93 NVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLR 152 Query: 298 GLEDLHRERIVYRDLKPENILLD-DHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 L +H I +RD+KP+N+LLD G +++ D G A + G+ + + Y APE+ Sbjct: 153 SLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYRAPEL 212 Query: 357 VKN-ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEV----------- 404 + YT + D W+ GC++ E++ GQ F + E+ +++ Sbjct: 213 IFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPN 272 Query: 405 ----------PEEYSERF----SPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 P +S+ F P A L S+LL P+ RL +A E HP F + Sbjct: 273 YMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARL-----TAIEALCHPFFDE 327 Query: 451 LNF--KRLGAGMLEPPF 465 L R+ G PP Sbjct: 328 LRTGEARMPNGRELPPL 344 >5Y86-A nrPDB Length = 588 Score = 222 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 89/460 (19%), Positives = 155/460 (33%), Gaps = 98/460 (21%) Query: 66 LFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPEVPRQL 125 LF+EF + + D K C + N S P ++P P Q Sbjct: 88 LFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKSSDCLNTVKSN-SSSKAPKVVPLTPEQA 146 Query: 126 VTNCTQRLEQG--------PCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLE 177 + L P + H + Y D+ Sbjct: 147 LKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYI-------- 198 Query: 178 RQPVTKN----TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALN 233 V ++ + +++GKG FG+V + A K + ++ + A Sbjct: 199 --HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEK----RFHRQAAE 252 Query: 234 EKQILEKVN------SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEAR 287 E +ILE + S V+ + ++ ++ +C+ L++ DL I GF Sbjct: 253 EIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS-IDLYELIKKNKFQGFSVQL 311 Query: 288 AVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHI--RISDLGLAVHVPEGQTIKGR 345 +A I L+ LH+ +I++ DLKPENILL HG ++ D G + E Q + Sbjct: 312 VRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTY 369 Query: 346 VGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIK------------ 393 + + Y APE++ RY+ D W+ GC+L E++ GQ F + + Sbjct: 370 IQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPP 429 Query: 394 ---REEVERLVKEVPEEYSERF-------------------------SPQARS------- 418 E+ +R + + R+ P ++ Sbjct: 430 PKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKG 489 Query: 419 --------LCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 + L DP+ RL + + HP K Sbjct: 490 CDDYLFIEFLKRCLHWDPSARL-----TPAQALRHPWISK 524 >2Y6O-A nrPDB Length = 291 Score = 222 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 53/254 (20%), Positives = 109/254 (42%), Gaps = 14/254 (5%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKM---YACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 + +V+G G FGEVC+ +++ GK A K L+ K++ + L+E I+ + + Sbjct: 16 IKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRD--FLSEASIMGQFD 73 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 ++ L + ++ M G L + F + V I G++ L Sbjct: 74 HPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRK-NDGRFTVIQLVGMLRGIGSGMKYL 132 Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT--IKGRVG--TVGYMAPEVVK 358 V+RDL NIL++ + ++SD G++ + + R G + + APE + Sbjct: 133 SDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA 192 Query: 359 NERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 ++T + D W+ G +++E+++ G+ P+ + + +E + P Sbjct: 193 YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPM---DCPIALH 249 Query: 418 SLCSQLLCKDPAER 431 L K+ ++R Sbjct: 250 QLMLDCWQKERSDR 263 >5KKR-C nrPDB Length = 395 Score = 222 bits (565), Expect = 4e-58, Method: Composition-based stats. Identities = 70/318 (22%), Positives = 129/318 (40%), Gaps = 51/318 (16%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 + + F + LG G G V + +G + A K + + K + E Q+L Sbjct: 64 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLH 121 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 + NS ++V A+ + + + + M+GG L + G+ PE + + GL Sbjct: 122 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGL 179 Query: 300 EDL-HRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVK 358 L + +I++RD+KP NIL++ G I++ D G++ + + VGT YM+PE ++ Sbjct: 180 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-NSFVGTRSYMSPERLQ 238 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPFQ-------------------------------- 386 Y+ D W++G L EM G+ P Sbjct: 239 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP 298 Query: 387 -------QRKKKIKREEVERLVKEVPEEYSE-RFSPQARSLCSQLLCKDPAERLGCRGGS 438 R E ++ +V E P + FS + + ++ L K+PAER Sbjct: 299 LSSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAER-----AD 353 Query: 439 AREVKEHPLFKKLNFKRL 456 +++ H K+ + + + Sbjct: 354 LKQLMVHAFIKRSDAEEV 371 >2R2P-A nrPDB Length = 295 Score = 222 bits (565), Expect = 5e-58, Method: Composition-based stats. Identities = 57/254 (22%), Positives = 107/254 (42%), Gaps = 14/254 (5%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKM---YACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 RV+G G FGEVC+ +++ GK A K L+ +K++ + L E I+ + + Sbjct: 24 ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRD--FLGEASIMGQFD 81 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 ++ L + +V M G L + F + V I G++ L Sbjct: 82 HPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKK-NDGQFTVIQLVGMLRGISAGMKYL 140 Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT--IKGRVG--TVGYMAPEVVK 358 V+RDL NIL++ + ++SD GL+ + + R G + + APE + Sbjct: 141 SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA 200 Query: 359 NERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 ++T + D W+ G +++E+++ G+ P+ + + + VE +P Sbjct: 201 FRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEG-YRLPSPM--DCPAALY 257 Query: 418 SLCSQLLCKDPAER 431 L K+ R Sbjct: 258 QLMLDCWQKERNSR 271 >1BYG-A nrPDB Length = 278 Score = 222 bits (565), Expect = 5e-58, Method: Composition-based stats. Identities = 60/269 (22%), Positives = 107/269 (39%), Gaps = 16/269 (5%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 + + + +GKG FG+V R G A K ++ L E ++ Sbjct: 16 WALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDAT-----AQAFLAEASVM 68 Query: 239 EKVNSRFVVSLAYAY-ETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 ++ +V L E K L +V M G L ++ G++ + ++ ++C Sbjct: 69 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 128 Query: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVV 357 +E L V+RDL N+L+ + ++SD GL Q V + APE + Sbjct: 129 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL--PVKWTAPEAL 186 Query: 358 KNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQA 416 + ++++ D W+ G LL+E+ + G+ P+ + K VE+ K + + P Sbjct: 187 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKM---DAPDGCPPAV 243 Query: 417 RSLCSQLLCKDPAERLGCRGGSAREVKEH 445 + D A R RE EH Sbjct: 244 YEVMKNCWHLDAAMRPSFLQ--LREQLEH 270 >6FEX-A nrPDB Length = 321 Score = 221 bits (564), Expect = 6e-58, Method: Composition-based stats. Identities = 63/307 (20%), Positives = 111/307 (36%), Gaps = 41/307 (13%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQV----------------RATGKMYACKKLEKK 220 R ++ R LG+G FGEV C+V + + A K L Sbjct: 9 PRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPD 68 Query: 221 RIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHM-- 278 K + + L E +I+ ++ ++ L D LC++ M GDL + Sbjct: 69 ATKNARND--FLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQL 126 Query: 279 ---------GQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISD 329 G + AA+I G+ L V+RDL N L+ ++ I+I+D Sbjct: 127 EDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIAD 186 Query: 330 LGLAVHVPEGQTIKGR---VGTVGYMAPEVVKNERYTFSPDWWALGCLLYE--MIAGQSP 384 G++ ++ G + + V + +MA E + ++T + D WA G L+E M+ P Sbjct: 187 FGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQP 246 Query: 385 FQQRKKKIKREEVERLVKE----VPEEYSERFSPQARSLCSQLLCKDPAERLGCRGG--- 437 F Q + E ++ V L + ++ +R Sbjct: 247 FGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRF 306 Query: 438 SAREVKE 444 A + Sbjct: 307 LAEDALN 313 >3I81-A nrPDB Length = 315 Score = 221 bits (564), Expect = 6e-58, Method: Composition-based stats. Identities = 68/306 (22%), Positives = 126/306 (41%), Gaps = 27/306 (8%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK-----MYACKKLEKKRIKKRKGEAMA 231 + V + R LG+G FG V + K A K + + + + E Sbjct: 11 DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIE--F 68 Query: 232 LNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQA--------GF 283 LNE ++++ N VV L +++ LM GDLK ++ + Sbjct: 69 LNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPP 128 Query: 284 PEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI- 342 ++ + A EI G+ L+ + V+RDL N ++ + ++I D G+ + E Sbjct: 129 SLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYR 188 Query: 343 KGRVG--TVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQR-KKKIKREEVE 398 KG G V +M+PE +K+ +T D W+ G +L+E+ + P+Q +++ R +E Sbjct: 189 KGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVME 248 Query: 399 RLVKEVPEEYSERFSPQARSLCSQLLCKDPAER--LGCRGGSAREVKEHPLFKKLNFKRL 456 + + P+ + L +P R S +E E P F++++F Sbjct: 249 GGLLDKPDNCPDMLFE----LMRMCWQYNPKMRPSFLEIISSIKEEME-PGFREVSFYYS 303 Query: 457 GAGMLE 462 +E Sbjct: 304 EENKME 309 >4H1J-A nrPDB Length = 293 Score = 221 bits (564), Expect = 6e-58, Method: Composition-based stats. Identities = 54/257 (21%), Positives = 111/257 (43%), Gaps = 13/257 (5%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQ---VRATGKMYACKKLEKKRIKKRKGEAMALNEKQI 237 + + R+LG+G FGEV + A K +K K ++E I Sbjct: 21 IAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNK--EKFMSEAVI 78 Query: 238 LEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 ++ ++ +V L E ++ +++ L G+L ++ + V Y+ +IC Sbjct: 79 MKNLDHPHIVKLIGIIE-EEPTWIIMELYPYGELGHYL-ERNKNSLKVLTLVLYSLQICK 136 Query: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVG--TVGYMAPE 355 + L V+RD+ NIL+ +++ D GL+ ++ + K V + +M+PE Sbjct: 137 AMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPE 196 Query: 356 VVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSP 414 + R+T + D W ++E+++ G+ PF + K +E+ + + P Sbjct: 197 SINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDR---LPKPDLCPP 253 Query: 415 QARSLCSQLLCKDPAER 431 +L ++ DP++R Sbjct: 254 VLYTLMTRCWDYDPSDR 270 >5L6P-A nrPDB Length = 298 Score = 221 bits (564), Expect = 6e-58, Method: Composition-based stats. Identities = 54/272 (19%), Positives = 112/272 (41%), Gaps = 18/272 (6%) Query: 187 RQYRVLGKGGFGEVCACQVRATGKM---YACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + V+G G FGEVC +++ G+ A K L+ ++++ + L+E I+ + + Sbjct: 22 KIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRD--FLSEASIMGQFDH 79 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 ++ L + ++ M L + + F + V I G++ L Sbjct: 80 PNIIRLEGVVTKSRPVMILTEFMENCALDSFLR-LNDGQFTVIQLVGMLRGIAAGMKYLS 138 Query: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHV---PEGQTIKGRVG---TVGYMAPEVV 357 V+RDL NIL++ + ++SD GL+ + P T +G + + APE + Sbjct: 139 EMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAI 198 Query: 358 KNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQA 416 ++T + D W+ G +++E+++ G+ P+ + VE+ + P Sbjct: 199 AYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPM---DCPTAL 255 Query: 417 RSLCSQLLCKDPAER--LGCRGGSAREVKEHP 446 L +D R + ++ +P Sbjct: 256 HQLMLDCWVRDRNLRPKFSQIVNTLDKLIRNP 287 >4EQM-A nrPDB Length = 294 Score = 221 bits (563), Expect = 7e-58, Method: Composition-based stats. Identities = 63/266 (23%), Positives = 112/266 (42%), Gaps = 5/266 (1%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 + ++ LG GG V + A K + +K + E Sbjct: 7 KIINERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSS 66 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 +++ + +VS+ E D LV+ + G L +I G A+ + +I G+ Sbjct: 67 QLSHQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGP--LSVDTAINFTNQILDGI 124 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR--VGTVGYMAPEVV 357 + H RIV+RD+KP+NIL+D + ++I D G+A + E + +GTV Y +PE Sbjct: 125 KHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQA 184 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKK-KIKREEVERLVKEVPEEYSERFSPQA 416 K E D +++G +LYEM+ G+ PF I + ++ V V + + Sbjct: 185 KGEATDECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQDSVPNVTTDVRKDIPQSL 244 Query: 417 RSLCSQLLCKDPAERLGCRGGSAREV 442 ++ + KD A R ++ Sbjct: 245 SNVILRATEKDKANRYKTIQEMKDDL 270 >3EQC-A nrPDB Length = 360 Score = 221 bits (563), Expect = 8e-58, Method: Composition-based stats. Identities = 70/318 (22%), Positives = 129/318 (40%), Gaps = 51/318 (16%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 + + F + LG G G V + +G + A K + + K + E Q+L Sbjct: 29 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE--IKPAIRNQIIRELQVLH 86 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 + NS ++V A+ + + + + M+GG L + G+ PE + + GL Sbjct: 87 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR--IPEQILGKVSIAVIKGL 144 Query: 300 EDL-HRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVK 358 L + +I++RD+KP NIL++ G I++ D G++ + + VGT YM+PE ++ Sbjct: 145 TYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-NSFVGTRSYMSPERLQ 203 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPFQ-------------------------------- 386 Y+ D W++G L EM G+ P Sbjct: 204 GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRP 263 Query: 387 -------QRKKKIKREEVERLVKEVPEEYSE-RFSPQARSLCSQLLCKDPAERLGCRGGS 438 R E ++ +V E P + FS + + ++ L K+PAER Sbjct: 264 LNKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAER-----AD 318 Query: 439 AREVKEHPLFKKLNFKRL 456 +++ H K+ + + + Sbjct: 319 LKQLMVHAFIKRSDAEEV 336 >5X5O-A nrPDB Length = 310 Score = 221 bits (562), Expect = 1e-57, Method: Composition-based stats. Identities = 61/269 (22%), Positives = 111/269 (41%), Gaps = 30/269 (11%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 + + + + G G FG V + + K A KKL K E +IL Sbjct: 12 IKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-----------IEKEAEILSV 60 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 ++ R ++ +V + G L +I + +A ++ G+ Sbjct: 61 LSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMH 120 Query: 301 DLHRE---RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVV 357 LH E ++++RDLK N+++ G ++I D G A T VGT +MAPEV+ Sbjct: 121 YLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEVI 179 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKK----IKREEVERLVKEVPEEYSERFS 413 ++ + + D ++ G +L+EM+ + PF+ + + E+ ERL +P F+ Sbjct: 180 QSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERL--TIPSSCPRSFA 237 Query: 414 PQARSLCSQLLCKDPAERLGCRGGSAREV 442 L Q D +R S +++ Sbjct: 238 E----LLHQCWEADAKKR-----PSFKQI 257 >3GQL-A nrPDB Length = 326 Score = 221 bits (562), Expect = 1e-57, Method: Composition-based stats. Identities = 61/303 (20%), Positives = 128/303 (42%), Gaps = 38/303 (12%) Query: 169 RFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK-------MYACKKLEKKR 221 + R + ++ + LG+G FG+V + K A K L+ Sbjct: 13 SEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDA 72 Query: 222 IKKRKGEAMALNEKQILEKV-NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQ 280 +K + ++E ++++ + + +++L A L +++ + G+L+ ++ Sbjct: 73 TEKDLSD--LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRP 130 Query: 281 AGF---------PEARA-----VFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIR 326 G PE + V A ++ G+E L ++ ++RDL N+L+ + ++ Sbjct: 131 PGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMK 190 Query: 327 ISDLGLAV---HVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQ 382 I+D GLA H+ + V +MAPE + + YT D W+ G LL+E+ G Sbjct: 191 IADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGG 250 Query: 383 SPFQQRKKKIKREEVERLVKEVPE-EYSERFSPQARSLCSQLLCKDPAERLGCRGGSARE 441 SP+ + EE+ +L+KE + + + + P++R + ++ Sbjct: 251 SPYPG----VPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQR-----PTFKQ 301 Query: 442 VKE 444 + E Sbjct: 302 LVE 304 >2WTK-C nrPDB Length = 305 Score = 220 bits (561), Expect = 1e-57, Method: Composition-based stats. Identities = 75/292 (25%), Positives = 134/292 (45%), Gaps = 20/292 (6%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKK-RKGEAMALNEKQILEKVNS 243 + +LG+G +G+V T A K L+KK++++ GEA E Q+L ++ Sbjct: 6 KYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRH 65 Query: 244 RFVVSLAYAY--ETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 + V+ L E K + +V+ G ++ + + + FP +A Y ++ GLE Sbjct: 66 KNVIQLVDVLYNEEKQKMYMVMEYCVCG-MQEMLDSVPEKRFPVCQAHGYFCQLIDGLEY 124 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPE---GQTIKGRVGTVGYMAPEVVK 358 LH + IV++D+KP N+LL G ++IS LG+A + T + G+ + PE+ Sbjct: 125 LHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEIAN 184 Query: 359 N-ERYT-FSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQA 416 + ++ F D W+ G LY + G PF+ E + + +P + S Sbjct: 185 GLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLS--- 241 Query: 417 RSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPD 468 L +L +PA+R S R++++H F+K + + P PD Sbjct: 242 -DLLKGMLEYEPAKRF-----SIRQIRQHSWFRKKHPPAEAP--VPIPPSPD 285 >3QUP-A nrPDB Length = 323 Score = 220 bits (561), Expect = 1e-57, Method: Composition-based stats. Identities = 69/303 (22%), Positives = 116/303 (38%), Gaps = 24/303 (7%) Query: 162 LDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATG---KMYACKKLE 218 LDS+ + L+ K LE + + F R+LGKG FG V Q++ A K L+ Sbjct: 2 LDSLGISDELKEK-LEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLK 60 Query: 219 KKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYET---KDAL---CLVLTLMNGGDLK 272 I E L E +++ + V L K L ++L M GDL Sbjct: 61 ADIIASSDIEE-FLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLH 119 Query: 273 FHIYH----MGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRIS 328 + P V + +I CG+E L ++RDL N +L + + ++ Sbjct: 120 AFLLASRIGENPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVA 179 Query: 329 DLGLAVHVPEGQTIKGRVGT---VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSP 384 D GL+ + G + + V ++A E + + YT D WA G ++E++ GQ+P Sbjct: 180 DFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTP 239 Query: 385 FQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER--LGCRGGSAREV 442 + + + + + + L Q DP +R C + Sbjct: 240 YAGIENAEIYNYLIGGNR---LKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENI 296 Query: 443 KEH 445 H Sbjct: 297 LGH 299 >4UY9-A nrPDB Length = 323 Score = 220 bits (561), Expect = 1e-57, Method: Composition-based stats. Identities = 61/264 (23%), Positives = 99/264 (37%), Gaps = 20/264 (7%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALN-EKQIL 238 + ++G GGFG+V G A K + + E ++ Sbjct: 5 EIDFAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLF 62 Query: 239 EKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 + +++L + LCLV+ GG L + P V +A +I G Sbjct: 63 AMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL---SGKRIPPDILVNWAVQIARG 119 Query: 299 LEDLHRE---RIVYRDLKPENILLD--------DHGHIRISDLGLAVHVPEGQTIKGRVG 347 + LH E I++RDLK NIL+ + ++I+D GLA + G Sbjct: 120 MNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSA-AG 178 Query: 348 TVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEE 407 T +MAPEV++ ++ D W+ G LL+E++ G+ PF+ V +P Sbjct: 179 TYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALP-- 236 Query: 408 YSERFSPQARSLCSQLLCKDPAER 431 L DP R Sbjct: 237 IPSTCPEPFAKLMEDCWNPDPHSR 260 >3VN9-A nrPDB Length = 340 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 61/277 (22%), Positives = 126/277 (45%), Gaps = 17/277 (6%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 V + LG+G +G V + +G++ A K++ + + ++ + + ++ + Sbjct: 47 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISMR 105 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG--FPEARAVFYAAEICC 297 V+ F V+ A + + + + LM+ L + G PE A I Sbjct: 106 TVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 Query: 298 GLEDLHRE-RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 LE LH + +++RD+KP N+L++ G +++ D G++ ++ + G YMAPE Sbjct: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPER 224 Query: 357 V----KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYS-ER 411 + + Y+ D W+LG + E+ + P+ ++++++V+E + ++ Sbjct: 225 INPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWG--TPFQQLKQVVEEPSPQLPADK 282 Query: 412 FSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 FS + SQ L K+ ER + E+ +HP F Sbjct: 283 FSAEFVDFTSQCLKKNSKER-----PTYPELMQHPFF 314 >3FME-A nrPDB Length = 290 Score = 219 bits (559), Expect = 2e-57, Method: Composition-based stats. Identities = 61/278 (21%), Positives = 126/278 (45%), Gaps = 17/278 (6%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 V + LG+G +G V + +G++ A K++ + + ++ + + ++ + Sbjct: 2 MEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRI-RATVNSQEQKRLLMDLDISM 60 Query: 239 EKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG--FPEARAVFYAAEIC 296 V+ F V+ A + + + + LM+ L + G PE A I Sbjct: 61 RTVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIV 119 Query: 297 CGLEDLHRE-RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPE 355 LE LH + +++RD+KP N+L++ G +++ D G++ ++ + G YMAPE Sbjct: 120 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPE 179 Query: 356 VV----KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYS-E 410 + + Y+ D W+LG + E+ + P+ ++++++V+E + + Sbjct: 180 RINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWG--TPFQQLKQVVEEPSPQLPAD 237 Query: 411 RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 +FS + SQ L K+ ER + E+ +HP F Sbjct: 238 KFSAEFVDFTSQCLKKNSKER-----PTYPELMQHPFF 270 >6BSD-A nrPDB Length = 876 Score = 219 bits (559), Expect = 2e-57, Method: Composition-based stats. Identities = 62/313 (19%), Positives = 110/313 (35%), Gaps = 47/313 (15%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQV----------------RATGKMYACKKLEKK 220 R ++ R LG+G FGEV C+V + + A K L Sbjct: 564 PRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPD 623 Query: 221 RIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHI----- 275 K + + L E +I+ ++ ++ L D LC++ M GDL + Sbjct: 624 ATKNARND--FLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQL 681 Query: 276 ------------YHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHG 323 + AA+I G+ L V+RDL N L+ ++ Sbjct: 682 EDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENF 741 Query: 324 HIRISDLGLAVHVPEGQTIKGR---VGTVGYMAPEVVKNERYTFSPDWWALGCLLYE--M 378 I+I+D G++ ++ G + + V + +MA E + ++T + D WA G L+E M Sbjct: 742 TIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLM 801 Query: 379 IAGQSPFQQRKKKIKREEVERLVKE----VPEEYSERFSPQARSLCSQLLCKDPAERLGC 434 + PF Q + E ++ V L + ++ +R Sbjct: 802 LCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPF 861 Query: 435 RGG---SAREVKE 444 A + Sbjct: 862 SQLHRFLAEDALN 874 >3PG1-A nrPDB Length = 362 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 72/308 (23%), Positives = 110/308 (35%), Gaps = 50/308 (16%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGE--------AMALNEKQI 237 + R + G +G VCA + G A K++ R L E ++ Sbjct: 24 YTVQRFISSGSYGAVCAGVD-SEGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 238 LEKVNSRFVVSLAYAYET-----KDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYA 292 L + ++ L + L LV LM DL I H + ++ Sbjct: 83 LNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRT-DLAQVI-HDQRIVISPQHIQYFM 140 Query: 293 AEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYM 352 I GL LH +V+RDL P NILL D+ I I D LA V Y Sbjct: 141 YHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHRWYR 200 Query: 353 APEVVKN-ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSER 411 APE+V + +T D W+ GC++ EM ++ F+ + ++ +V E Sbjct: 201 APELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVVM 260 Query: 412 FS----------------------------PQARSLCSQLLCKDPAERLGCRGGSAREVK 443 FS P A L +++L +P R+ S + Sbjct: 261 FSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRI-----STEQAL 315 Query: 444 EHPLFKKL 451 HP F+ L Sbjct: 316 RHPYFESL 323 >4UYA-A nrPDB Length = 340 Score = 219 bits (558), Expect = 3e-57, Method: Composition-based stats. Identities = 66/281 (23%), Positives = 109/281 (38%), Gaps = 27/281 (9%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI 222 +++YF V ++G GGFG+V + G+ A K + Sbjct: 12 ENLYFQG-------SPVHVAFERLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPE 62 Query: 223 KKRKGEAM-ALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQA 281 + A E ++ + ++ L + LCLVL GG L + Sbjct: 63 QDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALN---RALAGR 119 Query: 282 GFPEARAVFYAAEICCGLEDLHRE---RIVYRDLKPENILLDD--------HGHIRISDL 330 P V +A +I G+ LH E I++RDLK NILL + + ++I+D Sbjct: 120 RIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDF 179 Query: 331 GLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKK 390 GLA + G +MAPEV+K+ ++ D W+ G LL+E++ G+ P++ Sbjct: 180 GLAREWHRTTKMAT-AGAYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDG 238 Query: 391 KIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 V +P L + +DP R Sbjct: 239 LAVAYGVAVNKLTLP--IPSTCPEPFAKLMKECWQQDPHIR 277 >3DTC-A nrPDB Length = 271 Score = 219 bits (558), Expect = 3e-57, Method: Composition-based stats. Identities = 60/264 (22%), Positives = 98/264 (37%), Gaps = 20/264 (7%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALN-EKQIL 238 + ++G GGFG+V G A K + + E ++ Sbjct: 3 EIDFAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLF 60 Query: 239 EKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 + +++L + LCLV+ GG L + P V +A +I G Sbjct: 61 AMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL---SGKRIPPDILVNWAVQIARG 117 Query: 299 LEDLHRE---RIVYRDLKPENILLD--------DHGHIRISDLGLAVHVPEGQTIKGRVG 347 + LH E I++RDLK NIL+ + ++I+D GLA + G Sbjct: 118 MNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSA-AG 176 Query: 348 TVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEE 407 +MAPEV++ ++ D W+ G LL+E++ G+ PF+ V +P Sbjct: 177 AYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALP-- 234 Query: 408 YSERFSPQARSLCSQLLCKDPAER 431 L DP R Sbjct: 235 IPSTCPEPFAKLMEDCWNPDPHSR 258 >1LUF-A nrPDB Length = 343 Score = 219 bits (557), Expect = 3e-57, Method: Composition-based stats. Identities = 69/338 (20%), Positives = 119/338 (35%), Gaps = 48/338 (14%) Query: 147 RLTHEYLSVAPFADYLDSIYFNRFLQ------WKWLERQPVTKNTFRQYRVLGKGGFGEV 200 L+ P LD ++ N Q L +N R +G+G FG V Sbjct: 4 ESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRV 63 Query: 201 CACQVRATGK-------MYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAY 253 + A G M A K L+++ +A E ++ + ++ +V L Sbjct: 64 FQAR--APGLLPYEPFTMVAVKMLKEEA--SADMQADFQREAALMAEFDNPNIVKLLGVC 119 Query: 254 ETKDALCLVLTLMNGGDLKFHIYHM----------------------GQAGFPEARAVFY 291 +CL+ M GDL + M G A + Sbjct: 120 AVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPPLSCAEQLCI 179 Query: 292 AAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIK---GRVGT 348 A ++ G+ L + V+RDL N L+ ++ ++I+D GL+ ++ K Sbjct: 180 ARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKADGNDAIP 239 Query: 349 VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEE 407 + +M PE + RYT D WA G +L+E+ + G P+ E + + Sbjct: 240 IRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYG---MAHEEVIYYVRDGNILA 296 Query: 408 YSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEH 445 E + +L K PA+R S + + Sbjct: 297 CPENCPLELYNLMRLCWSKLPADR--PSFCSIHRILQR 332 >3M42-A nrPDB Length = 299 Score = 219 bits (557), Expect = 4e-57, Method: Composition-based stats. Identities = 61/285 (21%), Positives = 108/285 (37%), Gaps = 45/285 (15%) Query: 178 RQPVTKNTFRQ-YRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 ++ + ++ +VLG G G+V + T + +A K L+ +R+ E Sbjct: 11 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHW----- 65 Query: 237 ILEKVNSRFVVSLAYAYET----KDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYA 292 +V + YE + L +V+ ++GG+L I G F E A Sbjct: 66 --RASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIM 123 Query: 293 AEICCGLEDLHRERIVYRDLKPENILLDD---HGHIRISDLGLAVHVPEGQTIKGRVGTV 349 I ++ LH I +RD+KPEN+L + ++++D G A Sbjct: 124 KSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT------------ 171 Query: 350 GYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLV----KEVP 405 E+Y S D W+LG ++Y ++ G PF ++ + E P Sbjct: 172 ---------GEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFP 222 Query: 406 EEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 S + + L LL +P +R+ + E HP + Sbjct: 223 NPEWSEVSEEVKMLIRNLLKTEPTQRM-----TITEFMNHPWIMQ 262 >2VWV-A nrPDB Length = 302 Score = 218 bits (556), Expect = 4e-57, Method: Composition-based stats. Identities = 55/255 (21%), Positives = 106/255 (41%), Gaps = 16/255 (6%) Query: 187 RQYRVLGKGGFGEVCACQVRATGKM---YACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + V+G G FGEVC +++A GK A K L+ ++++ E L+E I+ + Sbjct: 19 KIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRRE--FLSEASIMGQFEH 76 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 ++ L + ++ M G L + + F + V I G+ L Sbjct: 77 PNIIRLEGVVTNSMPVMILTEFMENGALDSFLR-LNDGQFTVIQLVGMLRGIASGMRYLA 135 Query: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGT------VGYMAPEVV 357 V+RDL NIL++ + ++SD GL+ + E + + + + APE + Sbjct: 136 EMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTAPEAI 195 Query: 358 KNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQA 416 ++T + D W+ G +++E+++ G+ P+ + +E+ + P Sbjct: 196 AFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPP---DCPTSL 252 Query: 417 RSLCSQLLCKDPAER 431 L KD R Sbjct: 253 HQLMLDCWQKDRNAR 267 >5A46-A nrPDB Length = 386 Score = 218 bits (556), Expect = 4e-57, Method: Composition-based stats. Identities = 61/303 (20%), Positives = 128/303 (42%), Gaps = 38/303 (12%) Query: 169 RFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK-------MYACKKLEKKR 221 + R + ++ + LG+G FG+V + K A K L+ Sbjct: 25 SEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDA 84 Query: 222 IKKRKGEAMALNEKQILEKV-NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQ 280 +K + ++E ++++ + + +++L A L +++ + G+L+ ++ Sbjct: 85 TEKDLSD--LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRP 142 Query: 281 AGF---------PEARA-----VFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIR 326 G PE + V A ++ G+E L ++ ++RDL N+L+ + ++ Sbjct: 143 PGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMK 202 Query: 327 ISDLGLAV---HVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQ 382 I+D GLA H+ + V +MAPE + + YT D W+ G LL+E+ G Sbjct: 203 IADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGG 262 Query: 383 SPFQQRKKKIKREEVERLVKEVPE-EYSERFSPQARSLCSQLLCKDPAERLGCRGGSARE 441 SP+ + EE+ +L+KE + + + + P++R + ++ Sbjct: 263 SPYPG----VPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQR-----PTFKQ 313 Query: 442 VKE 444 + E Sbjct: 314 LVE 316 >5B2L-A nrPDB Length = 324 Score = 218 bits (556), Expect = 5e-57, Method: Composition-based stats. Identities = 67/284 (23%), Positives = 118/284 (41%), Gaps = 18/284 (6%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 +R N +G G G+V + R TG + A K++ + K + + + ++ Sbjct: 10 QRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSG-NKEENKRILMDLDV 68 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 +L+ + ++V + T + + + LM G + Q PE I Sbjct: 69 VLKSHDCPYIVQCFGTFITNTDVFIAMELM--GTSAEKLKKRMQGPIPERILGKMTVAIV 126 Query: 297 CGLEDL-HRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPE 355 L L + +++RD+KP NILLD+ G I++ D G++ + + + G YMAPE Sbjct: 127 KALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPE 186 Query: 356 VV-----KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE 410 + Y D W+LG L E+ GQ P++ K E + ++++E P Sbjct: 187 RIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTD--FEVLTKVLQEEPPLLPG 244 Query: 411 R--FSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 FS +S L KD +R ++ EH K+ Sbjct: 245 HMGFSGDFQSFVKDCLTKDHRKR-----PKYNKLLEHSFIKRYE 283 >2HK5-A nrPDB Length = 270 Score = 218 bits (555), Expect = 5e-57, Method: Composition-based stats. Identities = 55/263 (20%), Positives = 109/263 (41%), Gaps = 13/263 (4%) Query: 172 QWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMA 231 W+ + + + + + + LG G FGEV K A K ++ + Sbjct: 4 PWEK-DAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTK-VAVKTMKPGSMS----VEAF 57 Query: 232 LNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFY 291 L E +++ + +V L A TK+ + ++ M G L + + P + + + Sbjct: 58 LAEANVMKTLQHDKLVKLH-AVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDF 116 Query: 292 AAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI--KGRVGTV 349 +A+I G+ + + ++RDL+ NIL+ +I+D GLA + + + +G + Sbjct: 117 SAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPI 176 Query: 350 GYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEY 408 + APE + +T D W+ G LL E++ G+ P+ +ER + Sbjct: 177 KWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRM---PR 233 Query: 409 SERFSPQARSLCSQLLCKDPAER 431 E + ++ + P ER Sbjct: 234 PENCPEELYNIMMRCWKNRPEER 256 >5AMN-A nrPDB Length = 299 Score = 218 bits (555), Expect = 6e-57, Method: Composition-based stats. Identities = 65/278 (23%), Positives = 117/278 (42%), Gaps = 24/278 (8%) Query: 173 WKWLE--RQPVTKNTFRQYRVLGKGGFGEVCACQV-RATGK----MYACKKLEKKRIKKR 225 +K LE + + + LG+G FG+V G+ A K L++ Sbjct: 10 FKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSE 69 Query: 226 KGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG--- 282 + L+E +L++VN V+ L A L L++ G L+ + + G Sbjct: 70 LRD--LLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGY 127 Query: 283 -----FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVP 337 + +A +I G++ L ++V+RDL NIL+ + ++ISD GL+ V Sbjct: 128 PDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVY 187 Query: 338 EGQTIKGR---VGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIK 393 E + R V +MA E + + YT D W+ G LL+E++ G +P+ + Sbjct: 188 EEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERL 247 Query: 394 REEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 ++ + E + S + L Q ++P +R Sbjct: 248 FNLLKTGHRM---ERPDNCSEEMYRLMLQCWKQEPDKR 282 >3OMV-A nrPDB Length = 307 Score = 218 bits (555), Expect = 6e-57, Method: Composition-based stats. Identities = 67/263 (25%), Positives = 119/263 (45%), Gaps = 15/263 (5%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 +G G FG V + A K L+ + +A NE +L K ++ L Sbjct: 44 IGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQFQA-FRNEVAVLRKTRHVNIL-LFM 98 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 Y TKD L +V G L H+ H+ + F + + A + G++ LH + I++RD Sbjct: 99 GYMTKDNLAIVTQWCEGSSLYKHL-HVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRD 157 Query: 312 LKPENILLDDHGHIRISDLGLAV---HVPEGQTIKGRVGTVGYMAPEVVK---NERYTFS 365 +K NI L + ++I D GLA Q ++ G+V +MAPEV++ N ++F Sbjct: 158 MKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQ 217 Query: 366 PDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPE--EYSERFSPQARSLCSQL 423 D ++ G +LYE++ G+ P+ + + + P+ + + + L + Sbjct: 218 SDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADC 277 Query: 424 LCKDPAER-LGCRGGSAREVKEH 445 + K ER L + S+ E+ +H Sbjct: 278 VKKVKEERPLFPQILSSIELLQH 300 >5KMM-A nrPDB Length = 329 Score = 217 bits (554), Expect = 8e-57, Method: Composition-based stats. Identities = 50/274 (18%), Positives = 101/274 (36%), Gaps = 28/274 (10%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRA-----TGKMYACKKLEKKRIKKRKGEAMALNE 234 + + LG+G FG+V + + A K L++ R+ E Sbjct: 31 HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQD---FQRE 87 Query: 235 KQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQA------------- 281 ++L + + +V L +V M GDL + G Sbjct: 88 AELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG 147 Query: 282 GFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT 341 + + A+++ G+ L V+RDL N L+ ++I D G++ + Sbjct: 148 PLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDY 207 Query: 342 IKGRVGT---VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEV 397 + T + +M PE + ++T D W+ G +L+E+ G+ P+ Q E + Sbjct: 208 YRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNT---EAI 264 Query: 398 ERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 + + + E P+ ++ ++P +R Sbjct: 265 DCITQGRELERPRACPPEVYAIMRGCWQREPQQR 298 >6DBM-A nrPDB Length = 318 Score = 217 bits (553), Expect = 9e-57, Method: Composition-based stats. Identities = 65/292 (22%), Positives = 119/292 (40%), Gaps = 34/292 (11%) Query: 183 KNTFRQYRVLGKGGFGEVCAC----QVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 K ++ R LG+G FG+V TG+M A K L+ + + E IL Sbjct: 30 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADA--GPQHRSGWKQEIDIL 87 Query: 239 EKVNSRFVVSLAYAYETKD--ALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 + ++ E +L LV+ + G L+ ++ + A+ + +A +IC Sbjct: 88 RTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYL---PRHSIGLAQLLLFAQQIC 144 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRV----GTVGYM 352 G+ LH + ++RDL N+LLD+ ++I D GLA VPEG V + Sbjct: 145 EGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY 204 Query: 353 APEVVKNERYTFSPDWWALGCLLYEMIA-----GQSP--FQQRKKKIKREEVERLVKEVP 405 APE +K ++ ++ D W+ G LYE++ P F + + + + E+ Sbjct: 205 APECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELL 264 Query: 406 E-----EYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 E ++ + L + + R + + P+ K ++ Sbjct: 265 ERGERLPRPDKCPAEVYHLMKNCWETEASFR-----PTFENLI--PILKTVH 309 >5HI2-A nrPDB Length = 283 Score = 217 bits (552), Expect = 1e-56, Method: Composition-based stats. Identities = 65/272 (23%), Positives = 113/272 (41%), Gaps = 19/272 (6%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 + + + +G G FG V + A K L ++++ NE Sbjct: 13 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKMLTPQQLQ------AFKNEVG 63 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 +L K ++ L Y TK L +V G L H+ H + F + + A + Sbjct: 64 VLRKTRHVNIL-LFMGYSTKPQLAIVTQWCEGSSLYHHL-HASETKFEMKKLIDIARQTA 121 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAV---HVPEGQTIKGRVGTVGYMA 353 G++ LH + I++RDLK NI L + ++I D GLA + G++ +MA Sbjct: 122 RGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMA 181 Query: 354 PEVVK---NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPE--EY 408 PEV++ + Y+F D +A G +LYE++ GQ P+ + + E+ P+ + Sbjct: 182 PEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKV 241 Query: 409 SERFSPQARSLCSQLLCKDPAERLGCRGGSAR 440 + + L ++ L K ER A Sbjct: 242 RSNCPKRMKRLMAECLKKKRDERPSFPRILAE 273 >4XUF-A nrPDB Length = 297 Score = 216 bits (551), Expect = 2e-56, Method: Composition-based stats. Identities = 56/293 (19%), Positives = 109/293 (37%), Gaps = 37/293 (12%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQV---RATGK--MYACKKLEKKRIKKRKGEAMAL 232 + + +VLG G FG+V TG A K L++K + + Sbjct: 3 KWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSER--EALM 60 Query: 233 NEKQILEKVN-SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVF- 290 +E +++ ++ +V+L A + L+ GDL ++ + F E + Sbjct: 61 SELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRS-KREKFSEDEIEYE 119 Query: 291 ---------------------YAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISD 329 +A ++ G+E L + V+RDL N+L+ ++I D Sbjct: 120 NQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICD 179 Query: 330 LGLAVHVPEGQTIKGRVG---TVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 GLA + R V +MAPE + YT D W+ G LL+E+ + G +P+ Sbjct: 180 FGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPY 239 Query: 386 QQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGS 438 ++ + ++ + + + + + D +R + Sbjct: 240 PGIPVDANFYKLIQNGFKMDQPFYA--TEEIYIIMQSCWAFDSRKRPSFPNLT 290 >1FVR-A nrPDB Length = 327 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 57/278 (20%), Positives = 117/278 (42%), Gaps = 28/278 (10%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMY--ACKKLEKKRIKKRKGEAMALNEKQILEKV 241 N + V+G+G FG+V +++ G A K++++ K + E ++L K+ Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRD--FAGELEVLCKL 82 Query: 242 -NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMG--------------QAGFPEA 286 + +++L A E + L L + G+L + + Sbjct: 83 GHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQ 142 Query: 287 RAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRV 346 + + +AA++ G++ L +++ ++RDL NIL+ ++ +I+D GL+ Sbjct: 143 QLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGR 202 Query: 347 GTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVP 405 V +MA E + YT + D W+ G LL+E+++ G +P+ E++ + + Sbjct: 203 LPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYR--- 259 Query: 406 EEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVK 443 E + L Q + P ER S ++ Sbjct: 260 LEKPLNCDDEVYDLMRQCWREKPYER-----PSFAQIL 292 >4XCU-A nrPDB Length = 300 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 60/292 (20%), Positives = 119/292 (40%), Gaps = 29/292 (9%) Query: 171 LQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATG-------KMYACKKLEKKRIK 223 L ++ + LG+G FG+V + A K L+ Sbjct: 4 LDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASD 63 Query: 224 KRKGEAMALNEKQILEKV-NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG 282 K A ++E ++++ + + +++L + L +++ G+L+ + G Sbjct: 64 K--DLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPG 121 Query: 283 FPE-----ARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAV--- 334 E V A ++ G++ L + ++RDL N+L+ + ++I+D GLA Sbjct: 122 SSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVH 181 Query: 335 HVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIK 393 H+ + V +MAPE + + YT D W+ G LL+E+ G SP+ I Sbjct: 182 HIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPG----IP 237 Query: 394 REEVERLVKEVPE-EYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKE 444 EE+ L++E + P+ L + P++R + +++ E Sbjct: 238 VEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQR-----PTFKQLVE 284 >2W1I-A nrPDB Length = 326 Score = 215 bits (547), Expect = 5e-56, Method: Composition-based stats. Identities = 59/297 (19%), Positives = 123/297 (41%), Gaps = 29/297 (9%) Query: 160 DYLDSIYFNRFLQWKWLERQPVTKNT--FRQYRVLGKGGFGEVCACQVRA----TGKMYA 213 +++YF + + +R P + + LGKG FG V C+ TG++ A Sbjct: 15 PTTENLYFQGAMGSAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVA 74 Query: 214 CKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYET--KDALCLVLTLMNGGDL 271 KKL+ + + E +IL+ + +V + + L L++ + G L Sbjct: 75 VKKLQHSTEEHLRD---FEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSL 131 Query: 272 KFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLG 331 + ++ + + + Y ++IC G+E L +R ++RDL NIL+++ ++I D G Sbjct: 132 RDYLQKHKER-IDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFG 190 Query: 332 LAVHVPEGQTIKGRV----GTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-----GQ 382 L +P+ + + + APE + +++ + D W+ G +LYE+ Sbjct: 191 LTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKS 250 Query: 383 SP--F------QQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 P F ++ + I +E L + + + ++ + +R Sbjct: 251 PPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQR 307 >2PSQ-A nrPDB Length = 370 Score = 215 bits (547), Expect = 5e-56, Method: Composition-based stats. Identities = 58/303 (19%), Positives = 127/303 (41%), Gaps = 38/303 (12%) Query: 169 RFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK-------MYACKKLEKKR 221 + + ++ + LG+G FG+V + K A K L+ Sbjct: 66 SEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDA 125 Query: 222 IKKRKGEAMALNEKQILEKV-NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQ 280 +K + ++E ++++ + + +++L A L +++ + G+L+ ++ Sbjct: 126 TEKDLSD--LVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP 183 Query: 281 AGF---------PEARAVF-----YAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIR 326 G PE + F ++ G+E L ++ ++RDL N+L+ ++ ++ Sbjct: 184 PGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMK 243 Query: 327 ISDLGLAV---HVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQ 382 I+D GLA ++ + V +MAPE + + YT D W+ G L++E+ G Sbjct: 244 IADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGG 303 Query: 383 SPFQQRKKKIKREEVERLVKEVPE-EYSERFSPQARSLCSQLLCKDPAERLGCRGGSARE 441 SP+ I EE+ +L+KE + + + + P++R + ++ Sbjct: 304 SPYPG----IPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR-----PTFKQ 354 Query: 442 VKE 444 + E Sbjct: 355 LVE 357 >1S9I-A nrPDB Length = 354 Score = 215 bits (547), Expect = 5e-56, Method: Composition-based stats. Identities = 71/315 (22%), Positives = 124/315 (39%), Gaps = 55/315 (17%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 + + F + LG G G V Q R +G + A K + + K + E Q+L Sbjct: 12 ELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLE--IKPAIRNQIIRELQVLH 69 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 + NS ++V A+ + + + + M+GG L + + PE + + GL Sbjct: 70 ECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKR--IPEEILGKVSIAVLRGL 127 Query: 300 EDL-HRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVK 358 L + +I++RD+KP NIL++ G I++ D G++ + + VGT YMAPE ++ Sbjct: 128 AYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-NSFVGTRSYMAPERLQ 186 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIK------------------------- 393 Y+ D W++G L E+ G+ P K Sbjct: 187 GTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRP 246 Query: 394 ------------------REEVERLVKEVPEEYSE-RFSPQARSLCSQLLCKDPAERLGC 434 E ++ +V E P + F+P + ++ L K+PAER Sbjct: 247 PGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADL 306 Query: 435 RGGSAREVKEHPLFK 449 + + H K Sbjct: 307 KMLT-----NHTFIK 316 >6O6Q-A nrPDB Length = 335 Score = 215 bits (547), Expect = 5e-56, Method: Composition-based stats. Identities = 76/349 (21%), Positives = 130/349 (37%), Gaps = 68/349 (19%) Query: 143 QELTRLTHEYLSVAP--FADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEV 200 Q ++R+ + LS P + DY D L KW + + R LG+G + EV Sbjct: 10 QSVSRVYADVLSTKPQSYWDYDD-------LNIKW-----NPQENYEILRKLGRGKYSEV 57 Query: 201 CACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV-NSRFVVSLAYAYETK--D 257 + K L+ + KK E IL+ + + ++++ Sbjct: 58 FLGIDLEKREKVVIKVLKPVKRKK------IKREISILKNLVDGPNIIAMLDVVREPQSK 111 Query: 258 ALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENI 317 L+ +N D + F + FY E+ L+ H I++RD+KP N+ Sbjct: 112 TPGLIFEHINNID-----FRSLYPTFTDYDIRFYMYELLKALDYSHSMGIMHRDVKPHNV 166 Query: 318 LLDDHGH-IRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVV-KNERYTFSPDWWALGCLL 375 ++D +R+ D GLA + G RV + + PE++ Y +S D W+ GC+L Sbjct: 167 MIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYFKGPELLVDYRLYDYSLDMWSFGCML 226 Query: 376 YEMIAGQSPFQQRK---------------------------------KKIKREEVERLVK 402 M+ + PF K + I + V+ Sbjct: 227 ASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNISLGEEYEDIGYYNKRQWVR 286 Query: 403 EVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 + E + S + L +LL D ERL +A+E +H F + Sbjct: 287 FMNENNKDLVSQEFLDLIDRLLRYDHQERL-----TAKEAMKHAYFDPI 330 >3QGY-A nrPDB Length = 286 Score = 215 bits (547), Expect = 5e-56, Method: Composition-based stats. Identities = 54/251 (21%), Positives = 105/251 (41%), Gaps = 14/251 (5%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 + +G G FG V K A K +++ + E + E +++ K++ Sbjct: 28 ELTFVQEIGSGQFGLVHLGYWLNKDK-VAIKTIKEGSMS----EDDFIEEAEVMMKLSHP 82 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 +V L + +CLV M G L ++ + F + ++C G+ L Sbjct: 83 KLVQLYGVCLEQAPICLVFEFMEHGCLSDYLR-TQRGLFAAETLLGMCLDVCEGMAYLEE 141 Query: 305 ERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGT---VGYMAPEVVKNER 361 +++RDL N L+ ++ I++SD G+ V + Q GT V + +PEV R Sbjct: 142 ACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQ-YTSSTGTKFPVKWASPEVFSFSR 200 Query: 362 YTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC 420 Y+ D W+ G L++E+ + G+ P++ R E++ + + S + Sbjct: 201 YSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLA---STHVYQIM 257 Query: 421 SQLLCKDPAER 431 + + P +R Sbjct: 258 NHCWKERPEDR 268 >3ORP-A nrPDB Length = 311 Score = 214 bits (546), Expect = 6e-56, Method: Composition-based stats. Identities = 59/269 (21%), Positives = 111/269 (41%), Gaps = 14/269 (5%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 + + +LG GG EV + + A K L + E Q +N Sbjct: 11 SDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALN 70 Query: 243 SRFVVSLAYAYETKDA----LCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 +V++ E + +V+ ++G L+ ++ G RA+ A+ C Sbjct: 71 HPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGP--MTPKRAIEVIADACQA 128 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR----VGTVGYMAP 354 L H+ I++RD+KP NI++ +++ D G+A + + + +GT Y++P Sbjct: 129 LNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSP 188 Query: 355 EVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSP 414 E + + D ++LGC+LYE++ G+ PF + R P E S Sbjct: 189 EQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHEGLSA 248 Query: 415 QARSLCSQLLCKDPAERLGCRGGSAREVK 443 ++ + L K+P R +A E++ Sbjct: 249 DLDAVVLKALAKNPENRYQ----TAAEMR 273 >5X8I-B nrPDB Length = 346 Score = 214 bits (546), Expect = 7e-56, Method: Composition-based stats. Identities = 77/335 (22%), Positives = 122/335 (36%), Gaps = 78/335 (23%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQ-VRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 V + LG+G FG+V C +A G+ A K ++ + A +E Q+L Sbjct: 9 DVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVD----RYCEAARSEIQVL 64 Query: 239 EKVN--SRF----VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYA 292 E +N V + +E +C+V L+ G I G F A Sbjct: 65 EHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELL-GLSTYDFIKENGFLPFRLDHIRKMA 123 Query: 293 AEICCGLEDLHRERIVYRDLKPENILLDD-------------------HGHIRISDLGLA 333 +IC + LH ++ + DLKPENIL + I++ D G A Sbjct: 124 YQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSA 183 Query: 334 VHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIK 393 + E + V T Y APEV+ ++ D W++GC+L E G + F K Sbjct: 184 TYDDEHHS--TLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEH 241 Query: 394 REEVERLVKEVPEEY----------------SERFSPQAR-------------------- 417 +ER++ +P+ + S R Sbjct: 242 LAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEH 301 Query: 418 ----SLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 L ++L DPA+R+ + RE +HP F Sbjct: 302 ERLFDLIQKMLEYDPAKRI-----TLREALKHPFF 331 >6FER-A nrPDB Length = 309 Score = 214 bits (546), Expect = 7e-56, Method: Composition-based stats. Identities = 70/312 (22%), Positives = 119/312 (38%), Gaps = 45/312 (14%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGK----------------MYACKKLEKKRI 222 + + LG+G FGEV C+V K + A K L Sbjct: 4 EEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADAN 63 Query: 223 KKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG 282 K + + L E +I+ ++ ++ L T D LC++ M GDL + Sbjct: 64 KNARND--FLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPN 121 Query: 283 FPEARAV--------FYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAV 334 + F A +I G++ L V+RDL N L+ + I+I+D G++ Sbjct: 122 SSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSR 181 Query: 335 HVPEGQTIK---GRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYE--MIAGQSPFQQRK 389 ++ G + V + +M+ E + ++T + D WA G L+E + P+ Q Sbjct: 182 NLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLS 241 Query: 390 KKIKREEVERLVKEVPEEYSERFSPQARS--LCSQLLCKDPAERLGCRGGSAREVKEHPL 447 ++V E E F Q R L +C D +L R+ K P Sbjct: 242 D-----------EQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWR-RDTKNRPS 289 Query: 448 FKKLNFKRLGAG 459 F++++ L G Sbjct: 290 FQEIHLLLLQQG 301 >1ZXE-A nrPDB Length = 303 Score = 214 bits (546), Expect = 7e-56, Method: Composition-based stats. Identities = 63/281 (22%), Positives = 113/281 (40%), Gaps = 38/281 (13%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 F + VLG+G FG+V + + YA KK+ + + L+E +L +N + Sbjct: 7 DFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHT----EEKLSTILSEVMLLASLNHQ 62 Query: 245 FVVSLAYAYETKDA-------------LCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFY 291 +VV A+ + L + + L I H Sbjct: 63 YVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLI-HSENLNQQRDEYWRL 121 Query: 292 AAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVP-------------- 337 +I L +H + I++R+LKP NI +D+ +++I D GLA +V Sbjct: 122 FRQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLP 181 Query: 338 -EGQTIKGRVGTVGYMAPEVVKN-ERYTFSPDWWALGCLLYEMIAGQSPFQ-QRKKKIKR 394 + +GT Y+A EV+ Y D ++LG + +EMI PF ++ Sbjct: 182 GSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY---PFSTGMERVNIL 238 Query: 395 EEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCR 435 +++ + E P ++ + + + L+ DP +R G R Sbjct: 239 KKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGAR 279 >4PDO-A nrPDB Length = 299 Score = 214 bits (545), Expect = 8e-56, Method: Composition-based stats. Identities = 53/254 (20%), Positives = 106/254 (41%), Gaps = 15/254 (5%) Query: 187 RQYRVLGKGGFGEVCACQVR-ATGKM---YACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 + +V+G G FGEV ++ ++GK A K L+ +K++ + L E I+ + + Sbjct: 37 TRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVD--FLGEAGIMGQFS 94 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 ++ L + ++ M G L + F + V I G++ L Sbjct: 95 HHNIIRLEGVISKYKPMMIITEYMENGALDKFLRE-KDGEFSVLQLVGMLRGIAAGMKYL 153 Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEG--QTIKGRVG--TVGYMAPEVVK 358 V+RDL NIL++ + ++SD GL+ + + T G + + APE + Sbjct: 154 ANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAIS 213 Query: 359 NERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 ++T + D W+ G +++E++ G+ P+ + E ++ + Sbjct: 214 YRKFTSASDVWSFGIVMWEVMTYGERPYWELSN---HEVMKAINDGFRLPTPMDCPSAIY 270 Query: 418 SLCSQLLCKDPAER 431 L Q ++ A R Sbjct: 271 QLMMQCWQQERARR 284 >5HIE-A nrPDB Length = 302 Score = 214 bits (545), Expect = 8e-56, Method: Composition-based stats. Identities = 63/263 (23%), Positives = 110/263 (41%), Gaps = 19/263 (7%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 + + + +G G FG V + A K L ++++ NE Sbjct: 29 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKMLTPQQLQ------AFKNEVG 79 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 +L K ++ L Y TK L +V G L H+ H+ + F + + A + Sbjct: 80 VLRKTRHVNIL-LFMGYSTKPQLAIVTQWCEGSSLYHHL-HIIETKFEMIKLIDIARQTA 137 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAV---HVPEGQTIKGRVGTVGYMA 353 G++ LH + I++RDLK NI L + ++I D GLA + G++ +MA Sbjct: 138 QGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMA 197 Query: 354 PEVVK---NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPE--EY 408 PEV++ Y+F D +A G +LYE++ GQ P+ + + + P+ + Sbjct: 198 PEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKV 257 Query: 409 SERFSPQARSLCSQLLCKDPAER 431 + L ++ L K ER Sbjct: 258 RSNCPKAMKRLMAECLKKKRDER 280 >3NIE-A nrPDB Length = 429 Score = 214 bits (545), Expect = 8e-56, Method: Composition-based stats. Identities = 76/394 (19%), Positives = 133/394 (33%), Gaps = 106/394 (26%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI 222 +++YF Q ++ V N + ++G+G +G V + K A KK+ + Sbjct: 12 ENLYF----QGAIIKNVKVPDN-YEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNR-MF 65 Query: 223 KKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKD-----ALCLVLTLMNGGDLKFHIYH 277 + L E IL ++ S +++ L +D L +VL + + DLK Sbjct: 66 EDLIDCKRILREITILNRLKSDYIIRLHDLIIPEDLLKFDELYIVLEIAD-SDLKKLFK- 123 Query: 278 MGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVP 337 E + G + +H I++RDLKP N LL+ ++I D GLA + Sbjct: 124 -TPIFLTEQHVKTILYNLLLGEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTIN 182 Query: 338 EG--------------------------QTIKGRVGTVGYMAPE-VVKNERYTFSPDWWA 370 + + V T Y APE ++ E YT S D W+ Sbjct: 183 SDKDIHIVNDLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWS 242 Query: 371 LGCLLYEMIA-------------------------------------------------G 381 GC+ E++ G Sbjct: 243 TGCIFAELLNMMKSHINNPTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIG 302 Query: 382 QSPFQQRKKKIKREEVERLVKEVP-------EEYSERFSPQARSLCSQLLCKDPAERLGC 434 P ++ K I ++EV + +K P + S + L +L + +R+ Sbjct: 303 TPP-EEDLKCITKQEVIKYIKLFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRI-- 359 Query: 435 RGGSAREVKEHPLFKKL---NFKRLGAGMLEPPF 465 + + HP K + N + + PF Sbjct: 360 ---TIDKALSHPYLKDVRKENLENFSTEKIILPF 390 >5FM2-A nrPDB Length = 355 Score = 214 bits (545), Expect = 9e-56, Method: Composition-based stats. Identities = 65/306 (21%), Positives = 120/306 (39%), Gaps = 36/306 (11%) Query: 157 PFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCAC-----QVRATGKM 211 P D +++ + + + + LG+G FG+V + RA Sbjct: 37 PSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTT 96 Query: 212 YACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDL 271 A K L++ + L+E +L++VN V+ L A L L++ G L Sbjct: 97 VAVKMLKENASPSELRD--LLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSL 154 Query: 272 KFHIYHMGQAG----------------------FPEARAVFYAAEICCGLEDLHRERIVY 309 + + + G + +A +I G++ L ++V+ Sbjct: 155 RGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVH 214 Query: 310 RDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGR---VGTVGYMAPEVVKNERYTFSP 366 RDL NIL+ + ++ISD GL+ V E + R V +MA E + + YT Sbjct: 215 RDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQS 274 Query: 367 DWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLC 425 D W+ G LL+E++ G +P+ + ++ + E + S + L Q Sbjct: 275 DVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRM---ERPDNCSEEMYRLMLQCWK 331 Query: 426 KDPAER 431 ++P +R Sbjct: 332 QEPDKR 337 >5TQX-A nrPDB Length = 655 Score = 214 bits (544), Expect = 1e-55, Method: Composition-based stats. Identities = 83/323 (25%), Positives = 140/323 (43%), Gaps = 37/323 (11%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 + LG GGFG VC Q R A K + K +E QI++K+N Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLE--LSTKNRERWCHEIQIMKKLNHAN 67 Query: 246 VVSLAYAYET-----KDALCLVLTLMNGGDLKFHIYHMGQA-GFPEARAVFYAAEICCGL 299 VV E D L + +GGDL+ + G E++ + ++I G+ Sbjct: 68 VVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGI 127 Query: 300 EDLHRERIVYRDLKPENILLDD-HGHI--RISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 LH +I++RDLKPENI+L D G I +I DLG A V +G+ VGT+ Y+APE+ Sbjct: 128 RYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAPEL 187 Query: 357 VKNERYTFSPDWWALGCLLYEMIAGQSPF-QQRKKKIKREEVERLVKEV----------- 404 +N+ YT + D+W+ G +++E IAG PF + E++++ + Sbjct: 188 FENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEV 247 Query: 405 --------PEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSARE-----VKEHPL-FKK 450 P + +L DP +R G + ++ + +H L K Sbjct: 248 RFSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRCFVLMDHILNLKI 307 Query: 451 LNFKRLGAGMLEPPFKPDPQAIY 473 ++ + + + P ++++ Sbjct: 308 VHILNMTSAKIISFLLPPDESLH 330 >6E4F-A nrPDB Length = 290 Score = 214 bits (544), Expect = 1e-55, Method: Composition-based stats. Identities = 50/244 (20%), Positives = 111/244 (45%), Gaps = 12/244 (4%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI 222 +++YF + + + LG G FG V + R A K +++ + Sbjct: 11 ENLYFQGTAGLGYGS-WEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSM 68 Query: 223 KKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG 282 E + E +++ ++ +V L + + ++ M G L ++ M + Sbjct: 69 S----EDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREM-RHR 123 Query: 283 FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI 342 F + + ++C +E L ++ ++RDL N L++D G +++SD GL+ +V + + Sbjct: 124 FQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDE-Y 182 Query: 343 KGRVGT---VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVE 398 VG+ V + PEV+ +++ D WA G L++E+ + G+ P+++ E + Sbjct: 183 TSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIA 242 Query: 399 RLVK 402 + ++ Sbjct: 243 QGLR 246 >3G0E-A nrPDB Length = 336 Score = 213 bits (543), Expect = 2e-55, Method: Composition-based stats. Identities = 59/309 (19%), Positives = 110/309 (35%), Gaps = 37/309 (11%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK-----MYACKKL 217 ++ + Q + + +N + LG G FG+V K A K L Sbjct: 25 NNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKML 84 Query: 218 EKKRIKKRKGEAMALNEKQILEKV-NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIY 276 + ++E ++L + N +V+L A ++ GDL + Sbjct: 85 KPSA--HLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLR 142 Query: 277 HMGQAGF----------------PEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLD 320 + + ++ ++ G+ L + ++RDL NILL Sbjct: 143 RKRDSFICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLT 202 Query: 321 DHGHIRISDLGLAVHVPEGQTI---KGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYE 377 +I D GLA + V +MAPE + N YTF D W+ G L+E Sbjct: 203 HGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWE 262 Query: 378 MIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSP-QARSLCSQLLCKDPAERLGCR 435 + + G SP+ + +++KE S +P + + DP +R Sbjct: 263 LFSLGSSPYPGMP---VDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKR---- 315 Query: 436 GGSAREVKE 444 + +++ + Sbjct: 316 -PTFKQIVQ 323 >4HZS-A nrPDB Length = 341 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 58/259 (22%), Positives = 102/259 (39%), Gaps = 12/259 (4%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRA-TGKMY--ACKKLEKKRIKKRKGEAMALNEKQI 237 + + R LG G FG V + A +GK A K L+ + + + + E Sbjct: 9 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 68 Query: 238 LEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 + ++ R ++ L T + +V L G L + Q F YA ++ Sbjct: 69 MHSLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKH-QGHFLLGTLSRYAVQVAE 126 Query: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIK----GRVGTVGYMA 353 G+ L +R ++RDL N+LL ++I D GL +P+ R + A Sbjct: 127 GMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCA 186 Query: 354 PEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERF 412 PE +K ++ + D W G L+EM GQ P+ ++++ + +P E Sbjct: 187 PESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPR--PEDC 244 Query: 413 SPQARSLCSQLLCKDPAER 431 ++ Q P +R Sbjct: 245 PQDIYNVMVQCWAHKPEDR 263 >4K33-A nrPDB Length = 325 Score = 212 bits (541), Expect = 3e-55, Method: Composition-based stats. Identities = 63/303 (20%), Positives = 125/303 (41%), Gaps = 38/303 (12%) Query: 169 RFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK-------MYACKKLEKKR 221 L+ + +++ + LG+G FG+V + K A K L+ Sbjct: 21 SELELPADPKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDA 80 Query: 222 IKKRKGEAMALNEKQILEKV-NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQ 280 K + ++E ++++ + + +++L A L +++ G+L+ + Sbjct: 81 TDKDLSD--LVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRP 138 Query: 281 AGF---------PEARAVF-----YAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIR 326 G PE + F A ++ G+E L ++ ++RDL N+L+ + ++ Sbjct: 139 PGLDYSFDTSKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMK 198 Query: 327 ISDLGLAVHVPEGQTIKGRVG---TVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQ 382 I+D GLA V K V +MAPE + + YT D W+ G LL+E+ G Sbjct: 199 IADFGLARDVHNLDYYKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGG 258 Query: 383 SPFQQRKKKIKREEVERLVKEVPE-EYSERFSPQARSLCSQLLCKDPAERLGCRGGSARE 441 SP+ I EE+ +L+KE + + + + P++R + ++ Sbjct: 259 SPYPG----IPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQR-----PTFKQ 309 Query: 442 VKE 444 + E Sbjct: 310 LVE 312 >6FYV-A nrPDB Length = 337 Score = 212 bits (541), Expect = 3e-55, Method: Composition-based stats. Identities = 74/335 (22%), Positives = 119/335 (35%), Gaps = 78/335 (23%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRA-TGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 V + + LG+G FG+V C G A K ++ + A +E Q+L Sbjct: 10 DVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVG----RYREAARSEIQVL 65 Query: 239 EKVNS--RF----VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYA 292 E +NS V + ++ +C+V L+ G I F A Sbjct: 66 EHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELL-GLSTYDFIKENSFLPFQIDHIRQMA 124 Query: 293 AEICCGLEDLHRERIVYRDLKPENILLDD-------------------HGHIRISDLGLA 333 +IC + LH ++ + DLKPENIL + I++ D G A Sbjct: 125 YQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA 184 Query: 334 VHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIK 393 + E + V T Y APEV+ ++ D W++GC+L E G + FQ K Sbjct: 185 TYDDEHHS--TLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEH 242 Query: 394 REEVERLVKEVPEEY----------------SERFSPQAR-------------------- 417 +ER++ +P+ + S R Sbjct: 243 LAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEH 302 Query: 418 ----SLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 L ++L DP +R+ + E +HP F Sbjct: 303 EKLFDLVRRMLEYDPTQRI-----TLDEALQHPFF 332 >1AD5-A nrPDB Length = 438 Score = 212 bits (540), Expect = 3e-55, Method: Composition-based stats. Identities = 55/261 (21%), Positives = 105/261 (40%), Gaps = 19/261 (7%) Query: 172 QWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMA 231 W+ + + + + + + LG G FGEV K A K ++ + Sbjct: 171 PWEK-DAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTK-VAVKTMKPGSMS----VEAF 224 Query: 232 LNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFY 291 L E +++ + +V L A TK+ + ++ M G L + + P + + + Sbjct: 225 LAEANVMKTLQHDKLVKLH-AVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDF 283 Query: 292 AAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGY 351 +A+I G+ + + ++RDL+ NIL+ +I+D GLA G + + Sbjct: 284 SAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLAR--------VGAKFPIKW 335 Query: 352 MAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSE 410 APE + +T D W+ G LL E++ G+ P+ +ER + E Sbjct: 336 TAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRM---PRPE 392 Query: 411 RFSPQARSLCSQLLCKDPAER 431 + ++ + P ER Sbjct: 393 NCPEELYNIMMRCWKNRPEER 413 >3KUL-B nrPDB Length = 325 Score = 212 bits (539), Expect = 4e-55, Method: Composition-based stats. Identities = 57/293 (19%), Positives = 109/293 (37%), Gaps = 30/293 (10%) Query: 163 DSIYFNRFLQWKWLERQPVTKN----------------TFRQYRVLGKGGFGEVCACQVR 206 +++YF L +P T +++G G GEVC ++R Sbjct: 12 ENLYFQGKLPEPQFYAEPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLR 71 Query: 207 ATGKM---YACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVL 263 G+ A K L+ ++++ + L+E I+ + + ++ L +V Sbjct: 72 VPGQRDVPVAIKALKAGYTERQRRD--FLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVT 129 Query: 264 TLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHG 323 M G L + F + V + G+ L V+RDL N+L+D + Sbjct: 130 EYMENGSLDTFLR-THDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNL 188 Query: 324 HIRISDLGLAVHVPEG----QTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYE-M 378 ++SD GL+ + + T G + + APE + ++ + D W+ G +++E + Sbjct: 189 VCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVL 248 Query: 379 IAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 G+ P+ + VE + L KD A+R Sbjct: 249 AYGERPYWNMTNRDVISSVEEGYR---LPAPMGCPHALHQLMLDCWHKDRAQR 298 >3ZBF-A nrPDB Length = 322 Score = 212 bits (539), Expect = 4e-55, Method: Composition-based stats. Identities = 65/292 (22%), Positives = 111/292 (38%), Gaps = 29/292 (9%) Query: 160 DYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQV-----RATGKM-YA 213 +++YF Q + +LG G FGEV +G++ A Sbjct: 13 PTTENLYF----QGSIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVA 68 Query: 214 CKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKF 273 K L+K + K E L E ++ K N ++ + ++L LM GGDL Sbjct: 69 VKTLKKGSTDQEKIE--FLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLT 126 Query: 274 HIYHMGQAGF-----PEARAVFYAAEICCGLEDLHRERIVYRDLKPENILL-----DDHG 323 ++ A F V +I G L R ++RDL N L+ Sbjct: 127 YLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPR 186 Query: 324 HIRISDLGLAVHVPEGQTIKGR---VGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA 380 ++I D GLA + + + R + V +MAPE + + +T D W+ G L++E++ Sbjct: 187 IVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILT 246 Query: 381 -GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 G P+ V+ + P +L +Q ++P +R Sbjct: 247 LGHQPYPAHSNLDVLNYVQTGGRLEP---PRNCPDDLWNLMTQCWAQEPDQR 295 >3N9X-A nrPDB Length = 432 Score = 212 bits (539), Expect = 5e-55, Method: Composition-based stats. Identities = 76/390 (19%), Positives = 129/390 (33%), Gaps = 103/390 (26%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI 222 +++YF ++ V N + ++G+G +G V + T K A KK+ + Sbjct: 12 ENLYFQG------IKNVHVPDN-YIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNR-MF 63 Query: 223 KKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKD-----ALCLVLTLMNGGDLKFHIYH 277 + L E IL ++ S +++ L D L +VL + + DLK Sbjct: 64 EDLIDCKRILREITILNRLKSDYIIRLYDLIIPDDLLKFDELYIVLEIAD-SDLKKLFK- 121 Query: 278 MGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVP 337 E + G +H I++RDLKP N LL+ +++ D GLA + Sbjct: 122 -TPIFLTEEHIKTILYNLLLGENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTIN 180 Query: 338 EG-----------------------QTIKGRVGTVGYMAPE-VVKNERYTFSPDWWALGC 373 + + V T Y APE ++ E YT S D W+ GC Sbjct: 181 SEKDTNIVNDLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGC 240 Query: 374 LLYEMI-----------AGQSPFQQRK--------------------------------- 389 + E++ F Sbjct: 241 IFAELLNMLQSHINDPTNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPT 300 Query: 390 ----KKIKREEVERLVKEVPEEYS-------ERFSPQARSLCSQLLCKDPAERLGCRGGS 438 K I + EV + +K P S +L +L +P +R+ + Sbjct: 301 EDDLKNINKPEVIKYIKLFPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRI-----T 355 Query: 439 AREVKEHPLFKKLNFKRLGA---GMLEPPF 465 + +HP K + K+L + PF Sbjct: 356 IDQALDHPYLKDVRKKKLENFSTKKIILPF 385 >2I6L-A nrPDB Length = 320 Score = 211 bits (538), Expect = 5e-55, Method: Composition-based stats. Identities = 67/317 (21%), Positives = 123/317 (38%), Gaps = 58/317 (18%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 + + LG GG G V + K A KK+ + + AL E +I+ +++ Sbjct: 12 RYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI---VLTDPQSVKHALREIKIIRRLDHD 68 Query: 245 FVVSLA--------------YAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVF 290 +V + + +++ +V M DL + Q E A Sbjct: 69 NIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMET-DLANVL---EQGPLLEEHARL 124 Query: 291 YAAEICCGLEDLHRERIVYRDLKPENILLD-DHGHIRISDLGLAVHVPEGQTIKGRVG-- 347 + ++ GL+ +H +++RDLKP N+ ++ + ++I D GLA + + KG + Sbjct: 125 FMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEG 184 Query: 348 --TVGYMAPEVVKN-ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEV 404 T Y +P ++ + YT + D WA GC+ EM+ G++ F + + + + + V Sbjct: 185 LVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVV 244 Query: 405 PEEYSER--------------------------FSPQARSLCSQLLCKDPAERLGCRGGS 438 EE + S +A Q+L P +RL + Sbjct: 245 HEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRL-----T 299 Query: 439 AREVKEHPLFKKLNFKR 455 A E HP +F Sbjct: 300 AEEALSHPYMSIYSFPM 316 >1U54-B nrPDB Length = 291 Score = 211 bits (538), Expect = 6e-55, Method: Composition-based stats. Identities = 57/259 (22%), Positives = 101/259 (38%), Gaps = 12/259 (4%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVR-ATGKMY--ACKKLEKKRIKKRKGEAMALNEKQI 237 + + R LG G FG V + +GK A K L+ + + + + E Sbjct: 15 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 74 Query: 238 LEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 + ++ R ++ L T + +V L G L + Q F YA ++ Sbjct: 75 MHSLDHRNLIRLYGVVLTP-PMKMVTELAPLGSLLDRLRKH-QGHFLLGTLSRYAVQVAE 132 Query: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIK----GRVGTVGYMA 353 G+ L +R ++RDL N+LL ++I D GL +P+ R + A Sbjct: 133 GMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCA 192 Query: 354 PEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERF 412 PE +K ++ + D W G L+EM GQ P+ ++++ + +P E Sbjct: 193 PESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPR--PEDC 250 Query: 413 SPQARSLCSQLLCKDPAER 431 ++ Q P +R Sbjct: 251 PQDIYNVMVQCWAHKPEDR 269 >3DLS-A nrPDB Length = 335 Score = 211 bits (537), Expect = 7e-55, Method: Composition-based stats. Identities = 65/303 (21%), Positives = 120/303 (39%), Gaps = 27/303 (8%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKR------IKKRKGEAMALNEKQ 236 + LG G FG V + K K ++K++ I+ K + L E Sbjct: 23 SQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTL-EIA 81 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGG-DLKFHIYHMGQAGFPEARAVFYAAEI 295 IL +V ++ + +E + LV+ G DL I + E A + ++ Sbjct: 82 ILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPR--LDEPLASYIFRQL 139 Query: 296 CCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPE 355 + L + I++RD+K ENI++ + I++ D G A ++ G+ GT+ Y APE Sbjct: 140 VSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPE 199 Query: 356 VVKNERY-TFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSP 414 V+ Y + W+LG LY ++ ++PF + ++ ++ + S Sbjct: 200 VLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIHPPYL----------VSK 249 Query: 415 QARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK-LNFKRLGAGMLEPPFKPDPQAIY 473 + SL S LL P R + ++ P + +N + KP+ + Sbjct: 250 ELMSLVSGLLQPVPERR-----TTLEKLVTDPWVTQPVNLADYTWEEVFRVNKPESGVLS 304 Query: 474 CKD 476 Sbjct: 305 AAS 307 >4X7Q-B nrPDB Length = 312 Score = 211 bits (537), Expect = 8e-55, Method: Composition-based stats. Identities = 69/275 (25%), Positives = 112/275 (40%), Gaps = 28/275 (10%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI---KKRKGEAMALNEKQILEKV 241 +R +LGKGGFG V A A K + + R+ E +L KV Sbjct: 32 EYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 91 Query: 242 N----SRFVVSLAYAYETKDALCLVLTL-MNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 V+ L +ET++ LVL + DL +I G G E + + ++ Sbjct: 92 GAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLG--EGPSRCFFGQVV 149 Query: 297 CGLEDLHRERIVYRDLKPENILLD-DHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPE 355 ++ H +V+RD+K ENIL+D G ++ D G + + + GT Y PE Sbjct: 150 AAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHD-EPYTDFDGTRVYSPPE 208 Query: 356 VVKNERYTF-SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSP 414 + +Y W+LG LLY+M+ G PF++ ++ + E + SP Sbjct: 209 WISRHQYHALPATVWSLGILLYDMVCGDIPFERDQE----------ILEAELHFPAHVSP 258 Query: 415 QARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFK 449 +L + L P+ R S E+ P + Sbjct: 259 DCCALIRRCLAPKPSSR-----PSLEEILLDPWMQ 288 >3CJF-A nrPDB Length = 309 Score = 210 bits (536), Expect = 9e-55, Method: Composition-based stats. Identities = 66/290 (22%), Positives = 119/290 (41%), Gaps = 32/290 (11%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCAC----QVR-ATGKMYACKKLEKKRIKKRKGEAMAL 232 + ++ + LG+G FG+V + AT + A K L++ + Sbjct: 21 KWEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSE--HRALM 78 Query: 233 NEKQILEKVNSR-FVVSLAYAYETKD-ALCLVLTLMNGGDLKFHIYHMGQAGFP------ 284 +E +IL + VV+L A L +++ G+L ++ P Sbjct: 79 SELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYK 138 Query: 285 ----EARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV---P 337 + Y+ ++ G+E L + ++RDL NILL + ++I D GLA + P Sbjct: 139 DFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDP 198 Query: 338 EGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREE 396 + + +MAPE + + YT D W+ G LL+E+ + G SP+ K EE Sbjct: 199 DYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVK---IDEE 255 Query: 397 VERLVKEVPEEYSERF-SPQARSLCSQLLCKDPAERLGCRGGSAREVKEH 445 R +KE + + +P+ +P++R + E+ EH Sbjct: 256 FCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQR-----PTFSELVEH 300 >3SXS-A nrPDB Length = 268 Score = 210 bits (535), Expect = 1e-54, Method: Composition-based stats. Identities = 53/270 (19%), Positives = 110/270 (40%), Gaps = 19/270 (7%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQI 237 + + + LG G FG V + + A K +++ + E E Q Sbjct: 2 HMELKREEITLLKELGSGQFGVVKLGKWKG-QYDVAVKMIKEGSMS----EDEFFQEAQT 56 Query: 238 LEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 + K++ +V + + +V ++ G L ++ G+ G ++ + ++C Sbjct: 57 MMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGK-GLEPSQLLEMCYDVCE 115 Query: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGT---VGYMAP 354 G+ L + ++RDL N L+D +++SD G+ +V + Q + VGT V + AP Sbjct: 116 GMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSS-VGTKFPVKWSAP 174 Query: 355 EVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFS 413 EV +Y+ D WA G L++E+ + G+ P+ +V + + S Sbjct: 175 EVFHYFKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLY---RPHLAS 231 Query: 414 PQARSLCSQLLCKDPAERLGCRGGSAREVK 443 + + P +R + +++ Sbjct: 232 DTIYQIMYSCWHELPEKR-----PTFQQLL 256 >4PWN-A nrPDB Length = 274 Score = 210 bits (535), Expect = 1e-54, Method: Composition-based stats. Identities = 65/267 (24%), Positives = 117/267 (43%), Gaps = 19/267 (7%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 +G+G F V T A +L+ +++ K + E ++L+ + +V Sbjct: 18 IGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSER-QRFKEEAEMLKGLQHPNIVRFYD 76 Query: 252 AYET----KDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE-- 305 ++E+ K + LV LM G LK ++ + +I GL+ LH Sbjct: 77 SWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKV--LRSWCRQILKGLQFLHTRTP 134 Query: 306 RIVYRDLKPENILLDDH-GHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTF 364 I++RDLK +NI + G ++I DLGLA K +GT +MAPE+ + E+Y Sbjct: 135 PIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEMYE-EKYDE 193 Query: 365 SPDWWALGCLLYEMIAGQSPFQQ-RKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQL 423 S D +A G + EM + P+ + + V VK P + + P+ + + Sbjct: 194 SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVK--PASFDKVAIPEVKEIIEGC 251 Query: 424 LCKDPAERLGCRGGSAREVKEHPLFKK 450 + ++ ER S +++ H F++ Sbjct: 252 IRQNKDERY-----SIKDLLNHAFFQE 273 >3E3P-A nrPDB Length = 360 Score = 210 bits (534), Expect = 2e-54, Method: Composition-based stats. Identities = 66/320 (20%), Positives = 125/320 (39%), Gaps = 57/320 (17%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 ER + F+ R+ G+G FG V + ++TG A KK+ + E Q Sbjct: 16 ERSRKEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVI-------QDPRFRNRELQ 68 Query: 237 ILEKV---NSRFVVSLAYAY-----ETKDALCL--VLTLMNGGDLKFHIYHMGQAGF--P 284 I++ + + +V L + + + L V+ + L + + P Sbjct: 69 IMQDLAVLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVP-DTLHRCCRNYYRRQVAPP 127 Query: 285 EARAVFYAAEICCGLEDLH--RERIVYRDLKPENILLDD-HGHIRISDLGLAVHVPEGQT 341 + ++ + LH + +RD+KP N+L+++ G +++ D G A + + Sbjct: 128 PILIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEP 187 Query: 342 IKGRVGTVGYMAPEVVKN-ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERL 400 + + Y APE++ + YT + D W++GC+ EM+ G+ F+ + E+ R+ Sbjct: 188 NVAYICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRV 247 Query: 401 VKEVPEEYSERFSP----------------------------QARSLCSQLLCKDPAERL 432 + E + +P +A L S LL P ER+ Sbjct: 248 LGCPSREVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERM 307 Query: 433 GCRGGSAREVKEHPLFKKLN 452 E HP F +L+ Sbjct: 308 KPY-----EALCHPYFDELH 322 >4XI2-A nrPDB Length = 446 Score = 210 bits (534), Expect = 2e-54, Method: Composition-based stats. Identities = 48/228 (21%), Positives = 104/228 (45%), Gaps = 11/228 (4%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 + + LG G FG V + R A K + + + E + E +++ Sbjct: 182 WEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIREGSMS----EDEFIEEAKVM 236 Query: 239 EKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 ++ +V L + + ++ M G L ++ M + F + + ++C Sbjct: 237 MNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREM-RHRFQTQQLLEMCKDVCEA 295 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGT---VGYMAPE 355 +E L ++ ++RDL N L++D G +++SD GL+ +V + + VG+ V + PE Sbjct: 296 MEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDE-YTSSVGSKFPVRWSPPE 354 Query: 356 VVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVK 402 V+ +++ D WA G L++E+ + G+ P+++ E + + ++ Sbjct: 355 VLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLR 402 >4E20-A nrPDB Length = 290 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 65/271 (23%), Positives = 115/271 (42%), Gaps = 27/271 (9%) Query: 183 KNTFRQYRVLGKGGFGEVCAC----QVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 K ++ R LG+G FG+V TG+M A K L++ + + E +IL Sbjct: 7 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGC--GPQLRSGWQREIEIL 64 Query: 239 EKVNSRFVVSLAYAYETKDA--LCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 + +V E + + LV+ + G L+ ++ + A+ + +A +IC Sbjct: 65 RTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYL---PRHCVGLAQLLLFAQQIC 121 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRV----GTVGYM 352 G+ LH + ++R L N+LLD+ ++I D GLA VPEG V + Sbjct: 122 EGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY 181 Query: 353 APEVVKNERYTFSPDWWALGCLLYEMIA----GQSP---FQQRKKKIKREEVERLVKEVP 405 APE +K ++ ++ D W+ G LYE++ QSP F + + + + E+ Sbjct: 182 APECLKECKFYYASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVLRLTELL 241 Query: 406 E-----EYSERFSPQARSLCSQLLCKDPAER 431 E +R + L + + R Sbjct: 242 ERGERLPRPDRCPCEIYHLMKNCWETEASFR 272 >5EG3-A nrPDB Length = 334 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 59/303 (19%), Positives = 126/303 (41%), Gaps = 38/303 (12%) Query: 169 RFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK-------MYACKKLEKKR 221 + + ++ + LG+G FG+V + K A K L+ Sbjct: 20 SEFELPEDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDA 79 Query: 222 IKKRKGEAMALNEKQILEKV-NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQ 280 +K + ++E ++++ + + +++L A L +++ + G+L+ ++ Sbjct: 80 TEKDLSD--LVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRP 137 Query: 281 AGF---------PEARAVF-----YAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIR 326 G PE + F ++ G+E L ++ ++RDL N+L+ ++ ++ Sbjct: 138 PGMELSPDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMK 197 Query: 327 ISDLGLAVHVPEGQTIKGRVG---TVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQ 382 I+D GLA + K V +MAPE + + YT D W+ G L++E+ G Sbjct: 198 IADFGLARDINNIDFFKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGG 257 Query: 383 SPFQQRKKKIKREEVERLVKEVPE-EYSERFSPQARSLCSQLLCKDPAERLGCRGGSARE 441 SP+ I EE+ +L+KE + + + + P++R + ++ Sbjct: 258 SPYPG----IPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQR-----PTFKQ 308 Query: 442 VKE 444 + E Sbjct: 309 LVE 311 >4YFF-A nrPDB Length = 311 Score = 209 bits (531), Expect = 3e-54, Method: Composition-based stats. Identities = 60/253 (23%), Positives = 103/253 (40%), Gaps = 11/253 (4%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 + ++G G FG+V + R K+ A K+ + M E IL ++N Sbjct: 43 EIEFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHP 100 Query: 245 FVVSLAYAYE-TKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 V+ A +V ++GG L ++ + + A ++ G+E LH Sbjct: 101 CVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRI-LDLQSKLIIAVDVAKGMEYLH 159 Query: 304 R--ERIVYRDLKPENILLDDHGHIRISDLGLAVHVP--EGQTIKGRVGTVGYMAPEVVKN 359 + I++RDL NILL + GH ++D G + + + + + G + +MAPEV Sbjct: 160 NLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQ 219 Query: 360 E-RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARS 418 RYT D ++ L+E++ G+ PF K ++ P YS S Sbjct: 220 CTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYS--IPKPISS 277 Query: 419 LCSQLLCKDPAER 431 L + P R Sbjct: 278 LLIRGWNACPEGR 290 >5ZTN-A nrPDB Length = 429 Score = 209 bits (531), Expect = 4e-54, Method: Composition-based stats. Identities = 64/245 (26%), Positives = 112/245 (45%), Gaps = 16/245 (6%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV--- 241 + +V+GKG FG+V + A K + ++ + A E +ILE + Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEK----RFHRQAAEEIRILEHLRKQ 153 Query: 242 ---NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 N+ V+ + + ++ +C+ L++ +L I GF +A I Sbjct: 154 DKDNTMNVIHMLENFTFRNHICMTFELLSM-NLYELIKKNKFQGFSLPLVRKFAHSILQC 212 Query: 299 LEDLHRERIVYRDLKPENILLDDHGH--IRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 L+ LH+ RI++ DLKPENILL G I++ D G + + E Q + + + Y APEV Sbjct: 213 LDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCY--EHQRVYTYIQSRFYRAPEV 270 Query: 357 VKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQA 416 + RY D W+LGC+L E++ G + + + L+ +P + S +A Sbjct: 271 ILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLG-MPSQKLLDASKRA 329 Query: 417 RSLCS 421 ++ S Sbjct: 330 KNFVS 334 >3RP9-A nrPDB Length = 458 Score = 208 bits (530), Expect = 4e-54, Method: Composition-based stats. Identities = 70/376 (18%), Positives = 125/376 (33%), Gaps = 101/376 (26%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + + ++G G +G VC + ++ A KK+ + + L E IL ++N Sbjct: 53 DRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKI-LRVFEDLIDCKRILREIAILNRLNH 111 Query: 244 RFVVSLAYAY-----ETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 VV + E D L +VL + D F E + G Sbjct: 112 DHVVKVLDIVIPKDVEKFDELYVVLEIA---DSDFKKLFRTPVYLTELHIKTLLYNLLVG 168 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT----------------- 341 ++ +H I++RDLKP N L++ +++ D GLA V + Sbjct: 169 VKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLV 228 Query: 342 -----------IKGRVGTVGYMAPE-VVKNERYTFSPDWWALGCLLYEMIA--------- 380 + G V T Y APE ++ E YT + D W++GC+ E++ Sbjct: 229 TFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAYH 288 Query: 381 --GQSPFQQRK----------------------------------------KKIKREEVE 398 F + +++E+ + Sbjct: 289 ADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDAK 348 Query: 399 RLVKEVPEEYSERF-------SPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 R ++ P+ S A L ++L +P +R+ + E HP FK++ Sbjct: 349 RYIRIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRI-----TINECLAHPFFKEV 403 Query: 452 NFKRLGAGMLEPPFKP 467 + E P Sbjct: 404 RIAEVETNATEKVRLP 419 >4M7I-A nrPDB Length = 299 Score = 208 bits (530), Expect = 5e-54, Method: Composition-based stats. Identities = 64/295 (21%), Positives = 123/295 (41%), Gaps = 38/295 (12%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 F + LG+GGFG V + + YA K++ + + E + L K+ Sbjct: 6 DFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPN--RELAREKVMREVKALAKLEHP 63 Query: 245 FVVSLAYAYETKD------------ALCLVLTLMNGGDLKFHIYHMGQAGFPEARA-VFY 291 +V A+ K+ L + + L +LK + E + Sbjct: 64 GIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHI 123 Query: 292 AAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT---------- 341 +I +E LH + +++RDLKP NI +++ D GL + + + Sbjct: 124 FLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPA 183 Query: 342 ---IKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVE 398 G+VGT YM+PE + Y+ D ++LG +L+E++ PF + ++++ Sbjct: 184 YARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLY---PFSTQMERVRTLTDV 240 Query: 399 RLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNF 453 R +K P +++++ + + +L P ER A + E+ +F+ L+F Sbjct: 241 RNLK-FPPLFTQKYPCEYV-MVQDMLSPSPMER-----PEAINIIENAVFEDLDF 288 >4KIK-B nrPDB Length = 677 Score = 208 bits (530), Expect = 5e-54, Method: Composition-based stats. Identities = 77/276 (27%), Positives = 122/276 (44%), Gaps = 32/276 (11%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 + LG GGFG V + TG+ A K+ ++ + R E L E QI+ ++ Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQC-RQELSPRNRERWCL-EIQIMRRLTHPN 78 Query: 246 VVSLAYAYETKDAL------CLVLTLMNGGDLKFHIYHMGQA-GFPEARAVFYAAEICCG 298 VV+ E L L + GGDL+ ++ G E + ++I Sbjct: 79 VVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASA 138 Query: 299 LEDLHRERIVYRDLKPENILL---DDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPE 355 L LH RI++RDLKPENI+L + +I DLG A + +G VGT+ Y+APE Sbjct: 139 LRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPE 198 Query: 356 VVKNERYTFSPDWWALGCLLYEMIAGQSPF-------QQRKKKIKREEVERLVKE----- 403 +++ ++YT + D+W+ G L +E I G PF Q K ++ EV+ +V E Sbjct: 199 LLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGT 258 Query: 404 --------VPEEYSERFSPQARSLCSQLLCKDPAER 431 P + + + +L P +R Sbjct: 259 VKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQR 294 >5VD3-A nrPDB Length = 311 Score = 208 bits (529), Expect = 6e-54, Method: Composition-based stats. Identities = 78/307 (25%), Positives = 129/307 (42%), Gaps = 17/307 (5%) Query: 142 FQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVC 201 FQ + +L V+ + +++ + + + + +F++ LG G +GEV Sbjct: 20 FQSMHQLQPR--RVSFRGEASETLQSPGYDPSR---PESFFQQSFQRLSRLGHGSYGEVF 74 Query: 202 ACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV-NSRFVVSLAYAYETKDALC 260 + + G++YA K+ + K A L E EKV V L A+E L Sbjct: 75 KVRSKEDGRLYAVKR-SMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILY 133 Query: 261 LVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLD 320 L L G L+ H G A PEA+ Y + L LH + +V+ D+KP NI L Sbjct: 134 LQTELC-GPSLQQHCEAWG-ASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLG 191 Query: 321 DHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA 380 G ++ D GL V + + + G YMAPE+++ Y + D ++LG + E+ Sbjct: 192 PRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGS-YGTAADVFSLGLTILEVAC 250 Query: 381 G-QSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSA 439 + P + R+ +P E++ S + RS+ +L DP R A Sbjct: 251 NMELPHGGEGWQQLRQGY------LPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLA 304 Query: 440 REVKEHP 446 V P Sbjct: 305 LPVLRQP 311 >3BBT-B nrPDB Length = 328 Score = 208 bits (529), Expect = 7e-54, Method: Composition-based stats. Identities = 55/264 (20%), Positives = 105/264 (39%), Gaps = 15/264 (5%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMY----ACKKLEKKRIKKRKGEAMALNEKQILEK 240 ++ +VLG G FG V G+ A K L + K E ++E I+ Sbjct: 16 ELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVE--FMDEALIMAS 73 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 ++ +V L + + LV LM G L ++ H + + + +I G+ Sbjct: 74 MDHPHLVRLLGVCLSPT-IQLVTQLMPHGCLLEYV-HEHKDNIGSQLLLNWCVQIAKGMM 131 Query: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVG---TVGYMAPEVV 357 L R+V+RDL N+L+ H++I+D GLA + + G + +MA E + Sbjct: 132 YLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECI 191 Query: 358 KNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQA 416 ++T D W+ G ++E++ G P+ + + +E+ + + Sbjct: 192 HYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGER---LPQPPICTIDV 248 Query: 417 RSLCSQLLCKDPAERLGCRGGSAR 440 + + D R + +A Sbjct: 249 YMVMVKCWMIDADSRPKFKELAAE 272 >5O2B-A nrPDB Length = 285 Score = 207 bits (528), Expect = 7e-54, Method: Composition-based stats. Identities = 67/267 (25%), Positives = 121/267 (45%), Gaps = 20/267 (7%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 LG+G F V T A +L+ +++ K + + E ++L+ + +V Sbjct: 24 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAE-QQRFKEEAEMLKGLQHPNIVRFYD 82 Query: 252 AYET----KDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE-- 305 ++E+ K + LV LM G LK ++ + +I GL+ LH Sbjct: 83 SWESILKGKKCIVLVTELMTSGTLKTYLKRF--KVMKPKVLRSWCRQILKGLQFLHTRTP 140 Query: 306 RIVYRDLKPENILLDDH-GHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTF 364 I++RDLK +NI + G ++I DLGLA + K +GT +MAPE+ + E Y Sbjct: 141 PIIHRDLKCDNIFITGPTGSVKIGDLGLAT-LMRTSFAKSVIGTPEFMAPEMYE-EHYDE 198 Query: 365 SPDWWALGCLLYEMIAGQSPFQQ-RKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQL 423 S D +A G + EM + P+ + + +V +K P +++ P+ + + Sbjct: 199 SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIK--PASFNKVTDPEVKEIIEGC 256 Query: 424 LCKDPAERLGCRGGSAREVKEHPLFKK 450 + ++ +ERL S R++ H F + Sbjct: 257 IRQNKSERL-----SIRDLLNHAFFAE 278 >2A1A-B nrPDB Length = 284 Score = 207 bits (528), Expect = 8e-54, Method: Composition-based stats. Identities = 62/264 (23%), Positives = 114/264 (43%), Gaps = 33/264 (12%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 F++ ++G GGFG+V + R GK Y K+++ K E + L K++ Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAE-------REVKALAKLDHV 64 Query: 245 FVVSLAYAYETKDA----------------LCLVLTLMNGGDLKFHIYHMGQAGFPEARA 288 +V ++ D L + + + G L+ I + A Sbjct: 65 NIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLA 124 Query: 289 VFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGT 348 + +I G++ +H ++++ RDLKP NI L D ++I D GL + GT Sbjct: 125 LELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGT 184 Query: 349 VGYMAPEVVKNERYTFSPDWWALGCLLYEMI-AGQSPFQQRKKKIKREEVERLVKEVPEE 407 + YM+PE + ++ Y D +ALG +L E++ + F+ K ++ + Sbjct: 185 LRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSK---FFTDLRDGI------ 235 Query: 408 YSERFSPQARSLCSQLLCKDPAER 431 S+ F + ++L +LL K P +R Sbjct: 236 ISDIFDKKEKTLLQKLLSKKPEDR 259 >3QA8-A nrPDB Length = 676 Score = 207 bits (528), Expect = 8e-54, Method: Composition-based stats. Identities = 67/210 (31%), Positives = 101/210 (48%), Gaps = 12/210 (5%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 + LG GGFG V + TG+ A K+ ++ K E QI++K+N Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQE--LSPKNRERWCLEIQIMKKLNHPN 73 Query: 246 VVSLAYAYE------TKDALCLVLTLMNGGDLKFHIYHMGQA-GFPEARAVFYAAEICCG 298 VVS + D L + GGDL+ ++ G E ++I Sbjct: 74 VVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSA 133 Query: 299 LEDLHRERIVYRDLKPENILLDDHGH---IRISDLGLAVHVPEGQTIKGRVGTVGYMAPE 355 L LH RI++RDLKPENI+L +I DLG A + +G+ VGT+ Y+APE Sbjct: 134 LRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPE 193 Query: 356 VVKNERYTFSPDWWALGCLLYEMIAGQSPF 385 +++ ++YT + D+W+ G L +E I G PF Sbjct: 194 LLEQKKYTVTVDYWSFGTLAFECITGFRPF 223 >6CTH-A nrPDB Length = 309 Score = 207 bits (528), Expect = 8e-54, Method: Composition-based stats. Identities = 70/268 (26%), Positives = 118/268 (44%), Gaps = 16/268 (5%) Query: 169 RFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGE 228 ++ E VT N F LG+GGFG V +R + A KK+ + ++G Sbjct: 1 SMRKFSLNELAKVTSN-FNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRA---SKQGI 56 Query: 229 AMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARA 288 +E +I+ ++ + +V L + L LV M G L HI+ G++ Sbjct: 57 KEYASEVKIISRLRHKNLVKLIGWCHERGELMLVYEFMANGSLDSHIFK-GKSLLTWEVR 115 Query: 289 VFYAAEICCGLEDLHRER---IVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKG- 344 ++ L LH E +++RD+K NI+LD + ++ D GLA V + +K Sbjct: 116 YRIVKDLASALLYLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKT 175 Query: 345 -RVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKE 403 GTVGYMAPE + + + + D ++ G + E+ +G+ + + K + E LV Sbjct: 176 LLAGTVGYMAPECLSSGKASKESDVYSFGVVALEIASGR---RSIEPKFEESEALLLVPW 232 Query: 404 VPEEYSERFSPQARSLCSQL-LCKDPAE 430 V E Y +L + DP + Sbjct: 233 VWESYGNERILDIAD--RKLGMAFDPKQ 258 >4Y83-A nrPDB Length = 332 Score = 207 bits (527), Expect = 1e-53, Method: Composition-based stats. Identities = 64/266 (24%), Positives = 111/266 (41%), Gaps = 25/266 (9%) Query: 189 YRVLG-----KGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 YR +G +G FG+V Q T K ACK + + K +I Sbjct: 73 YRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSD--------VEIQACFRH 124 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 + L A + + L + GG + + G E ++ + GL+ LH Sbjct: 125 ENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGP--MREFEIIWVTKHVLKGLDFLH 182 Query: 304 RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI-KGRVGTVGYMAPEVVKNERY 362 +++++ D+KP NI+ + + D GL+V + E K GT YM+PEV+ + Sbjct: 183 SKKVIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGH 241 Query: 363 TFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLV-KEVP--EEYSERFSPQARSL 419 + D ++LG L M G P+ +R + ++ K+ P E+ ++ SP R L Sbjct: 242 STKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMREL 301 Query: 420 CSQLLCKDPAERLGCRGGSAREVKEH 445 L ++P R A ++ +H Sbjct: 302 IEASLERNPNHR-----PRAADLLKH 322 >5U6B-A nrPDB Length = 307 Score = 207 bits (527), Expect = 1e-53, Method: Composition-based stats. Identities = 64/299 (21%), Positives = 128/299 (42%), Gaps = 26/299 (8%) Query: 162 LDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKM--YACKKLEK 219 +S+ + L+ K L V ++ + LG+G FG V Q+ + A K ++ Sbjct: 2 SNSLGISEELKEK-LRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKI 60 Query: 220 KRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAY------ETKDALCLVLTLMNGGDLKF 273 + + E L+E +++ + V+ L E+ A ++L M GDL Sbjct: 61 AICTRSELED-FLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHS 119 Query: 274 HIYHMG----QAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISD 329 + + P V + A+I G+E L +R ++RDL N +L+++ + ++D Sbjct: 120 FLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVAD 179 Query: 330 LGLAVHVPEGQTIK-GRVG--TVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 GL+ + G + GR+ V ++A E + + YT D W+ G ++E+ GQ+P+ Sbjct: 180 FGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPY 239 Query: 386 QQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKE 444 + + + + + + +L S+ +P +R S E++E Sbjct: 240 PGVENSEIYDYLRQGNR---LKQPADCLDGLYALMSRCWELNPQDR-----PSFTELRE 290 >4Y93-A nrPDB Length = 446 Score = 207 bits (526), Expect = 1e-53, Method: Composition-based stats. Identities = 49/256 (19%), Positives = 110/256 (42%), Gaps = 12/256 (4%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 + + LG G FG V + R A K +++ + E + E +++ Sbjct: 183 WEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMS----EDEFIEEAKVM 237 Query: 239 EKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 ++ +V L + + ++ M G L ++ M + F + + ++C Sbjct: 238 MNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREM-RHRFQTQQLLEMCKDVCEA 296 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI--KGRVGTVGYMAPEV 356 +E L ++ ++RDL N L++D G +++SD G+ +V + + G V + +PEV Sbjct: 297 MEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEV 356 Query: 357 VKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQ 415 + +++ D WA G L++E+ + G+ P+++ E + + ++ S + Sbjct: 357 LMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLR---LPRPHLASER 413 Query: 416 ARSLCSQLLCKDPAER 431 ++ + ER Sbjct: 414 VYAIMYSCWHEKADER 429 >3PP0-A nrPDB Length = 338 Score = 206 bits (525), Expect = 2e-53, Method: Composition-based stats. Identities = 64/271 (23%), Positives = 107/271 (39%), Gaps = 29/271 (10%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMY----ACKKLEKKRIKKRKGEAMALNEKQILEK 240 R+ +VLG G FG V G+ A K L + K E L+E ++ Sbjct: 18 ELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKE--ILDEAYVMAG 75 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 V S +V L T + LV LM G L H+ + + + +I G+ Sbjct: 76 VGSPYVSRLLGICLTST-VQLVTQLMPYGCLLDHVRE-NRGRLGSQDLLNWCMQIAKGMS 133 Query: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVG---TVGYMAPEVV 357 L R+V+RDL N+L+ H++I+D GLA + +T G + +MA E + Sbjct: 134 YLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESI 193 Query: 358 KNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEE--------- 407 R+T D W+ G ++E++ G P+ + + +E+ + Sbjct: 194 LRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMI 253 Query: 408 ------YSERFSPQARSLCSQL--LCKDPAE 430 P+ R L S+ + +DP Sbjct: 254 MVKCWMIDSECRPRFRELVSEFSRMARDPQR 284 >5U6C-A nrPDB Length = 315 Score = 206 bits (525), Expect = 2e-53, Method: Composition-based stats. Identities = 59/286 (20%), Positives = 115/286 (40%), Gaps = 21/286 (7%) Query: 163 DSIYFNRFLQWK-WLERQPVTKNTFRQYRVLGKGGFGEVCACQVR---ATGKMYACKKLE 218 +++YF + + LE + +N ++LG+G FG V ++ T A K ++ Sbjct: 14 ENLYFQGSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMK 73 Query: 219 KKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKD-----ALCLVLTLMNGGDLKF 273 +R+ E L+E ++ + V+ L ++L M GDL Sbjct: 74 LDNSSQREIEE-FLSEAACMKDFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHT 132 Query: 274 HIY----HMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISD 329 ++ G P + + +I G+E L ++RDL N +L D + ++D Sbjct: 133 YLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVAD 192 Query: 330 LGLAVHVPEGQTIK-GRVG--TVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPF 385 GL+ + G + GR+ V ++A E + + YT D WA G ++E+ G +P+ Sbjct: 193 FGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPY 252 Query: 386 QQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 + + + + + E + + DP +R Sbjct: 253 PGVQNHEMYDYLLHGHR---LKQPEDCLDELYEIMYSCWRTDPLDR 295 >5UIU-A nrPDB Length = 323 Score = 205 bits (523), Expect = 3e-53, Method: Composition-based stats. Identities = 69/250 (27%), Positives = 102/250 (40%), Gaps = 26/250 (10%) Query: 163 DSIYFN-----------RFLQWKWLERQPVTKNTFRQ------YRVLGKGGFGEVCACQV 205 +++YF RF + + E + VT N F + +G+GGFG V V Sbjct: 10 ENLYFQGENKSLEVSDTRFHSFSFYELKNVT-NNFDERPISVGGNKMGEGGFGVVYKGYV 68 Query: 206 RATGKMYACKKLE-KKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLT 264 T A KKL I + + E +++ K +V L D LCLV Sbjct: 69 NNT--TVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYV 126 Query: 265 LMNGGDLKFHIYHM-GQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHG 323 M G L + + G A G+ LH ++RD+K NILLD+ Sbjct: 127 YMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAF 186 Query: 324 HIRISDLGLAV---HVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA 380 +ISD GLA + VGT YMAPE ++ E T D ++ G +L E+I Sbjct: 187 TAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGE-ITPKSDIYSFGVVLLEIIT 245 Query: 381 GQSPFQQRKK 390 G + ++ Sbjct: 246 GLPAVDEHRE 255 >5O2C-A nrPDB Length = 380 Score = 205 bits (523), Expect = 3e-53, Method: Composition-based stats. Identities = 67/267 (25%), Positives = 121/267 (45%), Gaps = 20/267 (7%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 LG+G F V T A +L+ +++ K + + E ++L+ + +V Sbjct: 33 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAE-QQRFKEEAEMLKGLQHPNIVRFYD 91 Query: 252 AYET----KDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE-- 305 ++E+ K + LV LM G LK ++ + +I GL+ LH Sbjct: 92 SWESILKGKKCIVLVTELMTSGTLKTYLKRF--KVMKPKVLRSWCRQILKGLQFLHTRTP 149 Query: 306 RIVYRDLKPENILLDDH-GHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTF 364 I++RDLK +NI + G ++I DLGLA + K +GT +MAPE+ + E Y Sbjct: 150 PIIHRDLKCDNIFITGPTGSVKIGDLGLAT-LMRTSFAKSVIGTPEFMAPEMYE-EHYDE 207 Query: 365 SPDWWALGCLLYEMIAGQSPFQQ-RKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQL 423 S D +A G + EM + P+ + + +V +K P +++ P+ + + Sbjct: 208 SVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIK--PASFNKVTDPEVKEIIEGC 265 Query: 424 LCKDPAERLGCRGGSAREVKEHPLFKK 450 + ++ +ERL S R++ H F + Sbjct: 266 IRQNKSERL-----SIRDLLNHAFFAE 287 >3IO7-A nrPDB Length = 313 Score = 205 bits (521), Expect = 5e-53, Method: Composition-based stats. Identities = 55/274 (20%), Positives = 114/274 (41%), Gaps = 27/274 (9%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRA----TGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 + + + LGKG FG V C+ TG++ A KKL+ + + E + Sbjct: 25 FEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRD---FEREIE 81 Query: 237 ILEKVNSRFVVSLAYAYET--KDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAE 294 IL+ + +V + + L L++ + G L+ ++ + + + Y ++ Sbjct: 82 ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKER-IDHIKLLQYTSQ 140 Query: 295 ICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRV----GTVG 350 IC G+E L +R ++RDL NIL+++ ++I D GL +P+ + + Sbjct: 141 ICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIF 200 Query: 351 YMAPEVVKNERYTFSPDWWALGCLLYEMIA-----GQSP--F------QQRKKKIKREEV 397 + APE + +++ + D W+ G +LYE+ P F ++ + I + Sbjct: 201 WYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLI 260 Query: 398 ERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 E L + + + ++ + +R Sbjct: 261 ELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQR 294 >3LZB-A nrPDB Length = 327 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 56/255 (21%), Positives = 100/255 (39%), Gaps = 15/255 (5%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMY----ACKKLEKKRIKKRKGEAMALNEKQILEK 240 F++ +VLG G FG V G+ A K+L + K E L+E ++ Sbjct: 16 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKE--ILDEAYVMAS 73 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 V++ V L T + L+ LM G L ++ + + +I G+ Sbjct: 74 VDNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDN-IGSQYLLNWCVQIAKGMN 131 Query: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVG---TVGYMAPEVV 357 L R+V+RDL N+L+ H++I+D GLA + + G + +MA E + Sbjct: 132 YLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESI 191 Query: 358 KNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQA 416 + YT D W+ G ++E++ G P+ +E+ + + Sbjct: 192 LHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGER---LPQPPICTIDV 248 Query: 417 RSLCSQLLCKDPAER 431 + + D R Sbjct: 249 YMIMRKCWMIDADSR 263 >5GNK-A nrPDB Length = 297 Score = 203 bits (516), Expect = 2e-52, Method: Composition-based stats. Identities = 56/255 (21%), Positives = 101/255 (39%), Gaps = 15/255 (5%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMY----ACKKLEKKRIKKRKGEAMALNEKQILEK 240 F++ +VLG G FG V G+ A K+L + K E L+E ++ Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKE--ILDEAYVMAS 77 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 V++ V L T + L++ LM G L ++ + + +I G+ Sbjct: 78 VDNPHVCRLLGICLTST-VQLIMQLMPFGCLLDYVREHKDN-IGSQYLLNWCVQIAKGMN 135 Query: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVG---TVGYMAPEVV 357 L R+V+RDL N+L+ H++I+D GLA + + G + +MA E + Sbjct: 136 YLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESI 195 Query: 358 KNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQA 416 + YT D W+ G ++E++ G P+ +E+ + + Sbjct: 196 LHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGER---LPQPPICTIDV 252 Query: 417 RSLCSQLLCKDPAER 431 + + D R Sbjct: 253 YMIMVKCWMIDADSR 267 >2WO6-A nrPDB Length = 382 Score = 203 bits (516), Expect = 2e-52, Method: Composition-based stats. Identities = 63/251 (25%), Positives = 116/251 (46%), Gaps = 18/251 (7%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 + + ++GKG FG+V R + A K ++ K+ + + E ++LE +N Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQI----EVRLLELMN 108 Query: 243 SR------FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 ++V L + ++ LCLV +++ +L + + G +A ++C Sbjct: 109 KHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSY-NLYDLLRNTNFRGVSLNLTRKFAQQMC 167 Query: 297 CGLEDLH--RERIVYRDLKPENILLDDHGH--IRISDLGLAVHVPEGQTIKGRVGTVGYM 352 L L I++ DLKPENILL + I+I D G + + GQ I + + Y Sbjct: 168 TALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQL--GQRIYQYIQSRFYR 225 Query: 353 APEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERF 412 +PEV+ Y + D W+LGC+L EM G+ F + + ++ ++ P ++ Sbjct: 226 SPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQ- 284 Query: 413 SPQARSLCSQL 423 +P+AR +L Sbjct: 285 APKARKFFEKL 295 >5HVK-A nrPDB Length = 315 Score = 202 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 61/285 (21%), Positives = 109/285 (38%), Gaps = 33/285 (11%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 VLGKG FG+ R TG++ K+L + + + L E +++ + Sbjct: 15 DLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIR---FDEETQRTFLKEVKVMRCLEHP 71 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 V+ L + + GG L+ I M + +P ++ V +A +I G+ LH Sbjct: 72 NVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSM-DSQYPWSQRVSFAKDIASGMAYLHS 130 Query: 305 ERIVYRDLKPENILLDDHGHIRISDLGLAVHV---------------PEGQTIKGRVGTV 349 I++R+L N L+ ++ ++ ++D GLA + P+ + VG Sbjct: 131 MNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNP 190 Query: 350 GYMAPEVVKNERYTFSPDWWALGCLLYEMIAG---QSPFQQRKKKIKREEVERLVKEVPE 406 +MAPE++ Y D ++ G +L E+I + R L + P Sbjct: 191 YWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPP 250 Query: 407 EYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 F P + + DP +R EH + L Sbjct: 251 NCPPSFFP----ITVRCCDLDPEKRPSFVK------LEH-WLETL 284 >4OW8-A nrPDB Length = 283 Score = 202 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 65/263 (24%), Positives = 106/263 (40%), Gaps = 12/263 (4%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 +R R++ GG G+V G+ A K L+ + + E + +N Sbjct: 12 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 71 Query: 245 FVVSLAYAYE-----TKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 + S+ E LV+ L+NG L + G+ A+ + L Sbjct: 72 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDMLEQTGRAL 129 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKG--RVGTVGYMAPEVV 357 + H +V+RD+KP NIL+ G ++I+D G+A V + +GT Y+APE Sbjct: 130 QIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQA 189 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 + + D ++LG + YE ++G+ PF + +KE P P R Sbjct: 190 LGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTV---AMKHIKEPPPPLPPDLPPNVR 246 Query: 418 SLCSQLLCKDPAERLGCRGGSAR 440 L L K+PA R G A Sbjct: 247 ELIEITLVKNPAMRYRSGGPFAD 269 >4X3F-A nrPDB Length = 337 Score = 202 bits (515), Expect = 3e-52, Method: Composition-based stats. Identities = 65/263 (24%), Positives = 106/263 (40%), Gaps = 12/263 (4%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 +R R++ GG G+V G+ A K L+ + + E + +N Sbjct: 13 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 72 Query: 245 FVVSLAYAYE-----TKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 + S+ E LV+ L+NG L + G+ A+ + L Sbjct: 73 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDMLEQTGRAL 130 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKG--RVGTVGYMAPEVV 357 + H +V+RD+KP NIL+ G ++I+D G+A V + +GT Y+APE Sbjct: 131 QIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQA 190 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 + + D ++LG + YE ++G+ PF + +KE P P R Sbjct: 191 LGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTV---AMKHIKEPPPPLPPDLPPNVR 247 Query: 418 SLCSQLLCKDPAERLGCRGGSAR 440 L L K+PA R G A Sbjct: 248 ELIEITLVKNPAMRYRSGGPFAD 270 >6B2Q-A nrPDB Length = 317 Score = 202 bits (515), Expect = 3e-52, Method: Composition-based stats. Identities = 65/263 (24%), Positives = 106/263 (40%), Gaps = 12/263 (4%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 +R R++ GG G+V G+ A K L+ + + E + +N Sbjct: 33 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 92 Query: 245 FVVSLAYAYE-----TKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 + S+ E LV+ L+NG L + G+ A+ + L Sbjct: 93 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDMLEQTGRAL 150 Query: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKG--RVGTVGYMAPEVV 357 + H +V+RD+KP NIL+ G ++I+D G+A V + +GT Y+APE Sbjct: 151 QIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQA 210 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 + + D ++LG + YE ++G+ PF + +KE P P R Sbjct: 211 LGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTV---AMKHIKEPPPPLPPDLPPNVR 267 Query: 418 SLCSQLLCKDPAERLGCRGGSAR 440 L L K+PA R G A Sbjct: 268 ELIEITLVKNPAMRYRSGGPFAD 290 >5AP3-A nrPDB Length = 313 Score = 202 bits (515), Expect = 3e-52, Method: Composition-based stats. Identities = 67/303 (22%), Positives = 120/303 (39%), Gaps = 37/303 (12%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI 222 +++YF V + + +G GG +V ++YA K + + Sbjct: 16 ENLYFQSM---------SVKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEA 65 Query: 223 KKRKGEAMALNEKQILEKV--NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQ 280 + + NE L K+ +S ++ L T + +V+ DL + + Sbjct: 66 DNQTLD-SYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVME-CGNIDLNGWLKK--K 121 Query: 281 AGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQ 340 Y + + +H+ IV+ DLKP N L+ G +++ D G+A + Sbjct: 122 KSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDT 180 Query: 341 T---IKGRVGTVGYMAPEVVKNERYTFS-----------PDWWALGCLLYEMIAGQSPFQ 386 T +VGTV YM PE +K+ + D W+LGC+LY M G++PFQ Sbjct: 181 TSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ 240 Query: 387 QRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHP 446 Q +I + + E+ + + + L +DP +R+ S E+ HP Sbjct: 241 QIINQISKLHAI-IDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRI-----SIPELLAHP 294 Query: 447 LFK 449 + Sbjct: 295 YVQ 297 >3UIU-A nrPDB Length = 306 Score = 202 bits (514), Expect = 3e-52, Method: Composition-based stats. Identities = 61/277 (22%), Positives = 115/277 (41%), Gaps = 46/277 (16%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 F++ ++G GGFG+V + R GK Y ++++ K E + L K++ Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNNEKAE-------REVKALAKLDHV 65 Query: 245 FVVSLAYAYETKDA-----------------------------LCLVLTLMNGGDLKFHI 275 +V ++ D L + + + G L+ I Sbjct: 66 NIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWI 125 Query: 276 YHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVH 335 + A+ +I G++ +H +++++RDLKP NI L D ++I D GL Sbjct: 126 EKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTS 185 Query: 336 VPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMI-AGQSPFQQRKKKIKR 394 + GT+ YM+PE + ++ Y D +ALG +L E++ + F+ K Sbjct: 186 LKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSK---FF 242 Query: 395 EEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 ++ + S+ F + ++L +LL K P +R Sbjct: 243 TDLRDGI------ISDIFDKKEKTLLQKLLSKKPEDR 273 >6J5U-C nrPDB Length = 426 Score = 202 bits (514), Expect = 4e-52, Method: Composition-based stats. Identities = 82/287 (28%), Positives = 123/287 (42%), Gaps = 40/287 (13%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRAT---------GKMYACKKLEKKRIKKRKG 227 E + TKN FRQ +LG+GGFG V + T G + A K+L+ + + G Sbjct: 78 ELKNATKN-FRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQ---G 133 Query: 228 EAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEAR 287 L E L +++ +V L + LV M G L+ H++ G A Sbjct: 134 HKEWLTEVNYLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWAI 193 Query: 288 AVFYAAEICCGLEDLHRER--IVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI--- 342 + A GL LH + ++YRD K NILLD + ++SD GLA P G Sbjct: 194 RMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVS 253 Query: 343 KGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQ------------------SP 384 +GT GY APE V R T D ++ G +L E+I+G+ +P Sbjct: 254 TKVIGTHGYAAPEYVATGRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLVDWATP 313 Query: 385 FQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 + K+K+ R +L + P++ + A +L Q L D R Sbjct: 314 YLGDKRKLFRIMDTKLGGQYPQKGAFT----AANLALQCLNPDAKLR 356 >5TOS-A nrPDB Length = 395 Score = 201 bits (512), Expect = 5e-52, Method: Composition-based stats. Identities = 81/289 (28%), Positives = 123/289 (42%), Gaps = 42/289 (14%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVR---------ATGKMYACKKLEKKRIKKRKG 227 E + T+N FR V+G+GGFG V + TG + A KKL ++ + G Sbjct: 59 ELKLATRN-FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ---G 114 Query: 228 EAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQ--AGFPE 285 L E L +++ +V L + LV M G L+ H++ G P Sbjct: 115 HREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPW 174 Query: 286 ARAVFYAAEICCGLEDLHRE--RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQ--T 341 V A + GL LH + +++YRD+K NILLD + ++SD GLA P G Sbjct: 175 FLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSY 234 Query: 342 IKGRV-GTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQ------------------ 382 + RV GT GY APE + + D ++ G LL E+++G+ Sbjct: 235 VSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWA 294 Query: 383 SPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 P+ K+K+ RL + E + R + A Q L +P R Sbjct: 295 RPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAV----QCLSFEPKSR 339 >1U59-A nrPDB Length = 287 Score = 201 bits (511), Expect = 7e-52, Method: Composition-based stats. Identities = 57/247 (23%), Positives = 107/247 (43%), Gaps = 14/247 (5%) Query: 192 LGKGGFGEVCACQVRATGKM--YACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 LG G FG V R K A K L++ K E + E QI+ ++++ ++V L Sbjct: 18 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEE--MMREAQIMHQLDNPYIVRL 75 Query: 250 AYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 + + AL LV+ + GG L + + P + ++ G++ L + V+ Sbjct: 76 IGVCQAE-ALMLVMEMAGGGPLHKFLV-GKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 133 Query: 310 RDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVG----TVGYMAPEVVKNERYTFS 365 RDL N+LL + + +ISD GL+ + + + + APE + +++ Sbjct: 134 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSR 193 Query: 366 PDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLL 424 D W+ G ++E ++ GQ P+++ K +E+ + E P+ +L S Sbjct: 194 SDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRM---ECPPECPPELYALMSDCW 250 Query: 425 CKDPAER 431 +R Sbjct: 251 IYKWEDR 257 >6GVJ-A nrPDB Length = 429 Score = 200 bits (510), Expect = 1e-51, Method: Composition-based stats. Identities = 65/285 (22%), Positives = 115/285 (40%), Gaps = 28/285 (9%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 V + + +G GG +V ++YA K + + + + NE L K Sbjct: 141 VKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLD-SYRNEIAYLNK 198 Query: 241 V--NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 + +S ++ L T + +V+ DL + + Y + Sbjct: 199 LQQHSDKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKK--KKSIDPWERKSYWKNMLEA 255 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT---IKGRVGTVGYMAPE 355 + +H+ IV+ DLKP N L+ G +++ D G+A + T +VGTV YM PE Sbjct: 256 VHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPE 314 Query: 356 VVKNERYTFS-----------PDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEV 404 +K+ + D W+LGC+LY M G++PFQQ +I + + Sbjct: 315 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAI-IDPNH 373 Query: 405 PEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFK 449 E+ + + + L +DP +R+ S E+ HP + Sbjct: 374 EIEFPDIPEKDLQDVLKCCLKRDPKQRI-----SIPELLAHPYVQ 413 >5HLW-A nrPDB Length = 299 Score = 200 bits (509), Expect = 1e-51, Method: Composition-based stats. Identities = 56/252 (22%), Positives = 105/252 (41%), Gaps = 16/252 (6%) Query: 190 RVLGKGGFGEVCACQV-RATGKMY--ACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFV 246 V+G+G FG V + GK A K L RI + L E I++ + V Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN--RITDIGEVSQFLTEGIIMKDFSHPNV 83 Query: 247 VSLAYAYE-TKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 +SL ++ + +VL M GDL+ I + + + ++ G++ L + Sbjct: 84 LSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKYLASK 142 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGT-----VGYMAPEVVKNE 360 + V+RDL N +LD+ ++++D GLA + + + T V +MA E ++ + Sbjct: 143 KFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQTQ 202 Query: 361 RYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419 ++T D W+ G LL+E++ G P+ + + + + EY + Sbjct: 203 KFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEY---CPDPLYEV 259 Query: 420 CSQLLCKDPAER 431 + R Sbjct: 260 MLKCWHPKAEMR 271 >3HMP-A nrPDB Length = 342 Score = 200 bits (509), Expect = 1e-51, Method: Composition-based stats. Identities = 65/285 (22%), Positives = 115/285 (40%), Gaps = 28/285 (9%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 V + + +G GG +V ++YA K + + + + NE L K Sbjct: 53 VKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLD-SYRNEIAYLNK 110 Query: 241 V--NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 + +S ++ L T + +V+ DL + + Y + Sbjct: 111 LQQHSDKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKK--KKSIDPWERKSYWKNMLEA 167 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT---IKGRVGTVGYMAPE 355 + +H+ IV+ DLKP N L+ G +++ D G+A + T +VGTV YM PE Sbjct: 168 VHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPE 226 Query: 356 VVKNERYTFS-----------PDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEV 404 +K+ + D W+LGC+LY M G++PFQQ +I + + Sbjct: 227 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAI-IDPNH 285 Query: 405 PEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFK 449 E+ + + + L +DP +R+ S E+ HP + Sbjct: 286 EIEFPDIPEKDLQDVLKCCLKRDPKQRI-----SIPELLAHPYVQ 325 >4HVI-A nrPDB Length = 314 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 62/277 (22%), Positives = 111/277 (40%), Gaps = 34/277 (12%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRA----TGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 + + LGKG FG V C+ TG + A K+L+ +++ E Q Sbjct: 7 FEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRD---FQREIQ 63 Query: 237 ILEKVNSRFVVSLAYAYETKDA--LCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAE 294 IL+ ++S F+V L LV+ + G L+ + +A +R + Y+++ Sbjct: 64 ILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFL-QRHRARLDASRLLLYSSQ 122 Query: 295 ICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRV----GTVG 350 IC G+E L R V+RDL NIL++ H++I+D GLA +P + + Sbjct: 123 ICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIF 182 Query: 351 YMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQR--KKKIKREEVERLVKEVP--- 405 + APE + + ++ D W+ G +LYE+ + + + + ++VP Sbjct: 183 WYAPESLSDNIFSRQSDVWSFGVVLYELFT----YCDKSCSPSAEFLRMMGSERDVPALS 238 Query: 406 -----------EEYSERFSPQARSLCSQLLCKDPAER 431 + L P +R Sbjct: 239 RLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDR 275 >6DBN-A nrPDB Length = 316 Score = 200 bits (508), Expect = 2e-51, Method: Composition-based stats. Identities = 60/278 (21%), Positives = 109/278 (39%), Gaps = 25/278 (8%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRA----TGKMYACKKLEKKRIKKRKGEAMA 231 ++ K ++ R LG+G FG+V C+ TG+ A K L+ + A Sbjct: 27 VDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPE--SGGNHIADL 84 Query: 232 LNEKQILEKVNSRFVVSLAYAYETK--DALCLVLTLMNGGDLKFHIYHMGQAGFPEARAV 289 E +IL + +V + + L++ + G LK ++ + + Sbjct: 85 KKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNK-INLKQQL 143 Query: 290 FYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKG----R 345 YA +IC G++ L + V+RDL N+L++ ++I D GL + + R Sbjct: 144 KYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDR 203 Query: 346 VGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA----GQSP---FQQRKKKIKREE-V 397 V + APE + ++ + D W+ G L+E++ SP F + + V Sbjct: 204 DSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTV 263 Query: 398 ERLVKEVPE----EYSERFSPQARSLCSQLLCKDPAER 431 RLV + E + L + P+ R Sbjct: 264 TRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNR 301 >4MD7-E nrPDB Length = 391 Score = 199 bits (505), Expect = 4e-51, Method: Composition-based stats. Identities = 80/352 (22%), Positives = 136/352 (38%), Gaps = 57/352 (16%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 ++ ++ R LG+G + EV + +I K + E +ILE + Sbjct: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEK------VVVKILKPVKKKKIKREIKILENLR 89 Query: 243 S-RFVVSLAYAYETK--DALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 +++LA + LV +N D + + FY EI L Sbjct: 90 GGPNIITLADIVKDPVSRTPALVFEHVNNTD-----FKQLYQTLTDYDIRFYMYEILKAL 144 Query: 300 EDLHRERIVYRDLKPENILLD-DHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVV- 357 + H I++RD+KP N+++D +H +R+ D GLA GQ RV + + PE++ Sbjct: 145 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV 204 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKR----------EEVERLVKEVPEE 407 + Y +S D W+LGC+L MI + PF + E++ + + E Sbjct: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 Query: 408 YSERF------------------------SPQARSLCSQLLCKDPAERLGCRGGSAREVK 443 RF SP+A +LL D RL +ARE Sbjct: 265 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-----TAREAM 319 Query: 444 EHPLFKKL--NFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEP 493 EHP F + + R+G+ + +P A + + + + + EP Sbjct: 320 EHPYFYTVVKDQARMGSSSMPGGSEPVSSANMMSGISSVPEPEPLGPLAGEP 371 >2OZO-A nrPDB Length = 613 Score = 198 bits (504), Expect = 5e-51, Method: Composition-based stats. Identities = 68/330 (20%), Positives = 132/330 (40%), Gaps = 27/330 (8%) Query: 112 HTGPDLIPEVPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSV--APFADYLDSIYFNR 169 P + R++ T + P + + R SV +PF+D + Sbjct: 271 PAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVFESPFSDPEELKDKKL 330 Query: 170 FLQWKWLERQPVTKNTFRQYRV-LGKGGFGEVCACQVRATGKM--YACKKLEKKRIKKRK 226 FL+ ++ + LG G FG V R K A K L++ K Sbjct: 331 FLK----------RDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADT 380 Query: 227 GEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEA 286 E + E QI+ ++++ ++V L + + AL LV+ + GG L + + P + Sbjct: 381 EE--MMREAQIMHQLDNPYIVRLIGVCQAE-ALMLVMEMAGGGPLHKFLV-GKREEIPVS 436 Query: 287 RAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRV 346 ++ G++ L + V+R+L N+LL + + +ISD GL+ + + Sbjct: 437 NVAELLHQVSMGMKYLEEKNFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTAR 496 Query: 347 G----TVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLV 401 + + APE + +++ D W+ G ++E ++ GQ P+++ K +E+ Sbjct: 497 SAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGK 556 Query: 402 KEVPEEYSERFSPQARSLCSQLLCKDPAER 431 + E P+ +L S +R Sbjct: 557 RM---ECPPECPPELYALMSDCWIYKWEDR 583 >5O0Y-A nrPDB Length = 579 Score = 197 bits (502), Expect = 8e-51, Method: Composition-based stats. Identities = 62/264 (23%), Positives = 107/264 (40%), Gaps = 26/264 (9%) Query: 197 FGEVCACQVRATGKMYACKK--LEK--KRIKKRKGEAMALNEKQILEKVNSRFVVSLAYA 252 F EV + A K L K + KK A E +I ++++ +V L Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 253 Y-ETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRER--IVY 309 + D+ C VL G DL F++ E A +I L+ L+ + I++ Sbjct: 357 FSLDTDSFCTVLEYCEGNDLDFYLKQHKL--MSEKEARSIIMQIVNALKYLNEIKPPIIH 414 Query: 310 RDLKPENILLDDH---GHIRISDLGLAVHVPEGQT--------IKGRVGTVGYMAPEVV- 357 DLKP NILL + G I+I+D GL+ + + GT Y+ PE Sbjct: 415 YDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFV 474 Query: 358 ---KNERYTFSPDWWALGCLLYEMIAGQSPFQQR--KKKIKREEVERLVKEVPEEYSERF 412 + + + D W++G + Y+ + G+ PF ++ I +E EV Sbjct: 475 VGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVV 534 Query: 413 SPQARSLCSQLLCKDPAERLGCRG 436 +P+A++ + L +R+ + Sbjct: 535 TPEAKAFIRRCLAYRKEDRIDVQQ 558 >4TPT-A nrPDB Length = 303 Score = 197 bits (502), Expect = 8e-51, Method: Composition-based stats. Identities = 61/269 (22%), Positives = 106/269 (39%), Gaps = 29/269 (10%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 VLGKG FG+ +ATGK+ K+L + + + L E +++ ++ Sbjct: 1 DLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRC---DEETQKTFLTEVKVMRSLDHP 57 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 V+ L L+ + GG LK + M FP + V +A I G+ LH Sbjct: 58 NVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSM--DPFPWQQKVRFAKGIASGMAYLHS 115 Query: 305 ERIVYRDLKPENILLDDHGHIRISDLGLAVHV---------------------PEGQTIK 343 I++RDL N L+ + ++D GL+ + + + Sbjct: 116 MCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRY 175 Query: 344 GRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKE 403 VG +MAPE++ + Y + D ++ G +L E+I GQ + + + VK Sbjct: 176 TVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII-GQV-YADPDCLPRTLDFGLNVKL 233 Query: 404 VPEEY-SERFSPQARSLCSQLLCKDPAER 431 E++ P L + +P R Sbjct: 234 FWEKFVPTDCPPAFFPLAAICCRLEPESR 262 >3AOX-A nrPDB Length = 344 Score = 197 bits (502), Expect = 9e-51, Method: Composition-based stats. Identities = 64/272 (23%), Positives = 100/272 (36%), Gaps = 22/272 (8%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQ-----VRATGKMYACKKLEKKRIKKRKGEAMA 231 + + V + R LG G FGEV Q + A K L + + + E Sbjct: 40 DLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPE--VCSEQDELDF 97 Query: 232 LNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQA-----GFPEA 286 L E I+ K N + +V ++L LM GGDLK + Sbjct: 98 LMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAML 157 Query: 287 RAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHG---HIRISDLGLAVHVPEGQTI- 342 + A +I CG + L ++RD+ N LL G +I D G+A + Sbjct: 158 DLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYR 217 Query: 343 KGRVG--TVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVER 399 KG V +M PE +T D W+ G LL+E+ + G P+ + + E V Sbjct: 218 KGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTS 277 Query: 400 LVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 + P + + +Q P +R Sbjct: 278 GGRMDP---PKNCPGPVYRIMTQCWQHQPEDR 306 >2ZMD-A nrPDB Length = 390 Score = 197 bits (502), Expect = 9e-51, Method: Composition-based stats. Identities = 64/285 (22%), Positives = 114/285 (40%), Gaps = 28/285 (9%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 V + + +G GG +V ++YA K + + + + NE L K Sbjct: 53 VKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLD-SYRNEIAYLNK 110 Query: 241 V--NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 + +S ++ L T + +V+ DL + + Y + Sbjct: 111 LQQHSDKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKK--KKSIDPWERKSYWKNMLEA 167 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT---IKGRVGTVGYMAPE 355 + +H+ IV+ DLKP N L+ G +++ D G+A + T +VG V YM PE Sbjct: 168 VHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPE 226 Query: 356 VVKNERYTFS-----------PDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEV 404 +K+ + D W+LGC+LY M G++PFQQ +I + + Sbjct: 227 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAI-IDPNH 285 Query: 405 PEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFK 449 E+ + + + L +DP +R+ S E+ HP + Sbjct: 286 EIEFPDIPEKDLQDVLKCCLKRDPKQRI-----SIPELLAHPYVQ 325 >2PVN-A nrPDB Length = 352 Score = 197 bits (502), Expect = 1e-50, Method: Composition-based stats. Identities = 68/346 (19%), Positives = 127/346 (36%), Gaps = 67/346 (19%) Query: 146 TRLTHEY--LSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCAC 203 R+ + L + DY L +W E+ + + R +G+G + EV Sbjct: 24 ARVYADVNVLRPKEYWDY-------EALTVQWGEQ-----DDYEVVRKVGRGKYSEVFEG 71 Query: 204 QVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETK--DALCL 261 + K K +K K + + K + +V L + L Sbjct: 72 INVNNNE-----KCIIKILKPVKKKKIKREIKILQNLCGGPNIVKLLDIVRDQHSKTPSL 126 Query: 262 VLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDD 321 + +N D + + + +Y E+ L+ H + I++RD+KP N+++D Sbjct: 127 IFEYVNNTD-----FKVLYPTLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDH 181 Query: 322 HGH-IRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN-ERYTFSPDWWALGCLLYEMI 379 +R+ D GLA G+ RV + + PE++ + + Y +S D W+LGC+ MI Sbjct: 182 ELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMI 241 Query: 380 AGQSP-FQQRKKKIKREEVERLVKE---------------------------------VP 405 + P F + ++ +++ + Sbjct: 242 FRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYRIELDPQLEALVGRHSRKPWLKFMN 301 Query: 406 EEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 + SP+A +LL D ERL +A E HP F+++ Sbjct: 302 ADNQHLVSPEAIDFLDKLLRYDHQERL-----TALEAMTHPYFQQV 342 >5LPZ-A nrPDB Length = 332 Score = 197 bits (501), Expect = 1e-50, Method: Composition-based stats. Identities = 69/271 (25%), Positives = 117/271 (43%), Gaps = 30/271 (11%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 N F ++G GGFG+V ++ G A KKL + G+ + E + + K+ Sbjct: 17 NGFHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQ---GDREFMAEMETIGKIKH 72 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG--FPEARAVFYAAEICCGLED 301 R +V L + D LV M G L+ ++ +AG + A GL Sbjct: 73 RNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAF 132 Query: 302 LH---RERIVYRDLKPENILLDDHGHIRISDLGLAV---HVPEGQTIKGRVGTVGYMAPE 355 LH I++RD+K N+LLD++ R+SD G+A + ++ GT GY+ PE Sbjct: 133 LHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPE 192 Query: 356 VVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEV-PEEYSERFSP 414 ++ R + D ++ G +L E++ G+ P + VK+ S+ F P Sbjct: 193 YYQSFRCSTKGDVYSYGVVLLELLTGKRP--TDSPDFGDNNLVGWVKQHAKLRISDVFDP 250 Query: 415 QARSLCSQLLCKDPAERLGCRGGSAREVKEH 445 + L+ +DPA + E+ +H Sbjct: 251 E-------LMKEDPALEI--------ELLQH 266 >3PLS-A nrPDB Length = 298 Score = 197 bits (501), Expect = 1e-50, Method: Composition-based stats. Identities = 60/256 (23%), Positives = 106/256 (41%), Gaps = 16/256 (6%) Query: 190 RVLGKGGFGEVCACQVRATGKMY---ACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFV 246 RV+GKG FG V + + A K L RI + + L E ++ +N V Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLS--RITEMQQVEAFLREGLLMRGLNHPNV 84 Query: 247 VSLAYAYETKDAL-CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 ++L + L ++L M GDL I + + + ++ G+E L + Sbjct: 85 LALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNP-TVKDLISFGLQVARGMEYLAEQ 143 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI-----KGRVGTVGYMAPEVVKNE 360 + V+RDL N +LD+ ++++D GLA + + + + V + A E ++ Sbjct: 144 KFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTY 203 Query: 361 RYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419 R+T D W+ G LL+E++ G P++ + + + EY + Sbjct: 204 RFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEY---CPDSLYQV 260 Query: 420 CSQLLCKDPAERLGCR 435 Q DPA R R Sbjct: 261 MQQCWEADPAVRPTFR 276 >5LPV-A nrPDB Length = 296 Score = 197 bits (501), Expect = 1e-50, Method: Composition-based stats. Identities = 69/271 (25%), Positives = 117/271 (43%), Gaps = 30/271 (11%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 N F ++G GGFG+V ++ G A KKL + G+ + E + + K+ Sbjct: 17 NGFHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQ---GDREFMAEMETIGKIKH 72 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG--FPEARAVFYAAEICCGLED 301 R +V L + D LV M G L+ ++ +AG + A GL Sbjct: 73 RNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAF 132 Query: 302 LH---RERIVYRDLKPENILLDDHGHIRISDLGLAV---HVPEGQTIKGRVGTVGYMAPE 355 LH I++RD+K N+LLD++ R+SD G+A + ++ GT GY+ PE Sbjct: 133 LHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPE 192 Query: 356 VVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEV-PEEYSERFSP 414 ++ R + D ++ G +L E++ G+ P + VK+ S+ F P Sbjct: 193 YYQSFRCSTKGDVYSYGVVLLELLTGKRP--TDSPDFGDNNLVGWVKQHAKLRISDVFDP 250 Query: 415 QARSLCSQLLCKDPAERLGCRGGSAREVKEH 445 + L+ +DPA + E+ +H Sbjct: 251 E-------LMKEDPALEI--------ELLQH 266 >3C1X-A nrPDB Length = 373 Score = 197 bits (500), Expect = 2e-50, Method: Composition-based stats. Identities = 56/252 (22%), Positives = 107/252 (42%), Gaps = 16/252 (6%) Query: 190 RVLGKGGFGEVCACQV-RATGKMY--ACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFV 246 V+G+G FG V + GK A K L RI + L E I++ + V Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN--RITDIGEVSQFLTEGIIMKDFSHPNV 152 Query: 247 VSLAYAYE-TKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 +SL ++ + +VL M GDL+ I + + + ++ G++ L + Sbjct: 153 LSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKFLASK 211 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEG--QTIKGRVG---TVGYMAPEVVKNE 360 + V+RDL N +LD+ ++++D GLA + + ++ + G V +MA E ++ + Sbjct: 212 KFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQTQ 271 Query: 361 RYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419 ++T D W+ G LL+E++ G P+ + + + + EY + Sbjct: 272 KFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEY---CPDPLYEV 328 Query: 420 CSQLLCKDPAER 431 + R Sbjct: 329 MLKCWHPKAEMR 340 >3EB0-A nrPDB Length = 383 Score = 196 bits (499), Expect = 2e-50, Method: Composition-based stats. Identities = 61/339 (17%), Positives = 117/339 (34%), Gaps = 80/339 (23%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 + + + LG G FG VC +GK +A KK+ + K E I++ Sbjct: 3 ETSSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKN-------RELDIMK 55 Query: 240 KVNSRFVVSLAYAYET--------------------------------------KDALCL 261 ++ ++ L + T L + Sbjct: 56 VLDHVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNV 115 Query: 262 VLTLMNGGDLKFHIYHMGQAG--FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILL 319 ++ + L + ++G P Y ++ + +H I +RD+KP+N+L+ Sbjct: 116 IMEYVP-DTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLV 174 Query: 320 DD-HGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN-ERYTFSPDWWALGCLLYE 377 + +++ D G A + + + + Y APE++ YT S D W++GC+ E Sbjct: 175 NSKDNTLKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGE 234 Query: 378 MIAGQSPFQQRKKKIKREEVERLVKEVPEE--------------------YSERFSPQ-- 415 +I G+ F + + +++ +E + P+ Sbjct: 235 LILGKPLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKILPEGT 294 Query: 416 ---ARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 A L Q+L +P R+ E HP F L Sbjct: 295 PSLAIDLLEQILRYEPDLRINPY-----EAMAHPFFDHL 328 >3UIM-A nrPDB Length = 326 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 71/298 (23%), Positives = 119/298 (39%), Gaps = 26/298 (8%) Query: 156 APFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACK 215 A+ ++ + ++ E Q V + F +LG+GGFG+V ++ A G + A K Sbjct: 3 DVPAEEDPEVHLGQLKRFSLRELQ-VASDNFSNKNILGRGGFGKVYKGRL-ADGTLVAVK 60 Query: 216 KLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHI 275 +L+++R + GE E +++ R ++ L T LV M G + + Sbjct: 61 RLKEERTQ--GGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCL 118 Query: 276 YHM--GQAGFPEARAVFYAAEICCGLEDLHRE---RIVYRDLKPENILLDDHGHIRISDL 330 Q + A GL LH +I++RD+K NILLD+ + D Sbjct: 119 RERPESQPPLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDF 178 Query: 331 GLAVHVP--EGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQ-- 386 GLA + + GT+G++APE + + + D + G +L E+I GQ F Sbjct: 179 GLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQRAFDLA 238 Query: 387 ---QRKKKIKREEVERLVKEVPEEYSERF-------SPQARSLCSQLL---CKDPAER 431 + + V+ L+KE E + L L P ER Sbjct: 239 RLANDDDVMLLDWVKGLLKEKKLEALVDVDLQGNYKDEEVEQLIQVALLCTQSSPMER 296 >4JLC-A nrPDB Length = 657 Score = 195 bits (497), Expect = 3e-50, Method: Composition-based stats. Identities = 53/238 (22%), Positives = 102/238 (42%), Gaps = 17/238 (7%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 Q + + + +LG+G V + + TG +YA K + + E ++L Sbjct: 3 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ--MREFEVL 60 Query: 239 EKVNSRFVVSLAYAYE--TKDALCLVLTLMNGGDLKFHIYHMGQA-GFPEARAVFYAAEI 295 +K+N + +V L E T L++ G L + A G PE+ + ++ Sbjct: 61 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 120 Query: 296 CCGLEDLHRERIVYRDLKPENIL--LDDHGH--IRISDLGLAVHVPEGQTIKGRVGTVGY 351 G+ L IV+RD+KP NI+ + + G +++D G A + + + GT Y Sbjct: 121 VGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 180 Query: 352 MAPEVVK--------NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLV 401 + P++ + ++Y + D W++G Y G PF+ + + +EV + Sbjct: 181 LHPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKI 238 >2RIO-A nrPDB Length = 434 Score = 195 bits (496), Expect = 4e-50, Method: Composition-based stats. Identities = 87/331 (26%), Positives = 140/331 (42%), Gaps = 52/331 (15%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL-EKV 241 KN ++LG G G V Q G+ A K++ +AL E ++L E Sbjct: 14 KNLVVSEKILGYGSSGTVVF-QGSFQGRPVAVKRMLIDFCD------IALMEIKLLTESD 66 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGG--DL--KFHIYHMGQAGFPEARAVFYAAEICC 297 + V+ + T L + L L N DL ++ E + +I Sbjct: 67 DHPNVIRYYCSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIAS 126 Query: 298 GLEDLHRERIVYRDLKPENILLD-------------DHGHIRISDLGLAVHVPEGQT--- 341 G+ LH +I++RDLKP+NIL+ ++ I ISD GL + GQ+ Sbjct: 127 GVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFR 186 Query: 342 --IKGRVGTVGYMAPEVVKN-------ERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKK 391 + GT G+ APE+++ R T S D +++GC+ Y +++ G+ PF K Sbjct: 187 TNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF--GDKY 244 Query: 392 IKREEVERLVKEVPEE---YSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 + + R + + E + +A L SQ++ DP +R +A +V HPLF Sbjct: 245 SRESNIIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKR-----PTAMKVLRHPLF 299 Query: 449 ----KKLNFKRLGAGMLEPPFKPDPQAIYCK 475 KKL F + LE + P A+ K Sbjct: 300 WPKSKKLEFLLKVSDRLEIENRDPPSALLMK 330 >4IDT-A nrPDB Length = 356 Score = 195 bits (496), Expect = 4e-50, Method: Composition-based stats. Identities = 69/252 (27%), Positives = 106/252 (42%), Gaps = 22/252 (8%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 LG+G FGEV + + TG A KK+ + + E + S +V L Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE--------ELMACAGLTSPRIVPLYG 133 Query: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 A + + + L+ GG L + G PE RA++Y + GLE LH RI++ D Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLVKEQG--CLPEDRALYYLGQALEGLEYLHSRRILHGD 191 Query: 312 LKPENILLDDHG-HIRISDLGLAVHVPEGQTIKGRV------GTVGYMAPEVVKNERYTF 364 +K +N+LL G H + D G AV + K + GT +MAPEVV Sbjct: 192 VKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCDA 251 Query: 365 SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPE--EYSERFSPQARSLCSQ 422 D W+ C++ M+ G P+ Q + ++ E P E +P + Sbjct: 252 KVDVWSSCCMMLHMLNGCHPWTQF---FRGPLCLKIASEPPPVREIPPSCAPLTAQAIQE 308 Query: 423 LLCKDPAERLGC 434 L K+P R+ Sbjct: 309 GLRKEPIHRVSA 320 >4F0G-A nrPDB Length = 287 Score = 195 bits (496), Expect = 4e-50, Method: Composition-based stats. Identities = 56/264 (21%), Positives = 108/264 (40%), Gaps = 18/264 (6%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKL----EKKRIKKRKGEAMALNEKQ 236 + N + +GKGGFG V ++ + A K L + + + E Sbjct: 16 LADNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVF 75 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 I+ +N +V L + +V+ + GDL + + + +I Sbjct: 76 IMSNLNHPNIVKLYG--LMHNPPRMVMEFVPCGDLYHRLLDKAHP-IKWSVKLRLMLDIA 132 Query: 297 CGLEDLHRER--IVYRDLKPENILL---DDHGHI--RISDLGLAVHVPEGQTIKGRVGTV 349 G+E + + IV+RDL+ NI L D++ + +++D GL+ ++ G +G Sbjct: 133 LGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVH--SVSGLLGNF 190 Query: 350 GYMAPEVV--KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEE 407 +MAPE + + E YT D ++ +LY ++ G+ PF + + + + Sbjct: 191 QWMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGLRPT 250 Query: 408 YSERFSPQARSLCSQLLCKDPAER 431 E P+ R++ DP +R Sbjct: 251 IPEDCPPRLRNVIELCWSGDPKKR 274 >4LRM-A nrPDB Length = 334 Score = 195 bits (495), Expect = 5e-50, Method: Composition-based stats. Identities = 56/258 (21%), Positives = 100/258 (38%), Gaps = 18/258 (6%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMY----ACKKLEKKRIKKRKGEAMALNEKQILEK 240 F++ +VLG G FG V G+ A K+L + K E L+E ++ Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKE--ILDEAYVMAS 77 Query: 241 VNSR---FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 V++ V L T + L+ LM G L ++ + + +I Sbjct: 78 VDNPGNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHKDN-IGSQYLLNWCVQIAK 135 Query: 298 GLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVG---TVGYMAP 354 G+ L R+V+RDL N+L+ H++I+D GLA + + G + +MA Sbjct: 136 GMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMAL 195 Query: 355 EVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFS 413 E + + YT D W+ G ++E++ G P+ +E+ + + Sbjct: 196 ESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGER---LPQPPICT 252 Query: 414 PQARSLCSQLLCKDPAER 431 + + D R Sbjct: 253 IDVYMIMVKCWMIDADSR 270 >4EUU-A nrPDB Length = 319 Score = 194 bits (493), Expect = 9e-50, Method: Composition-based stats. Identities = 51/238 (21%), Positives = 102/238 (42%), Gaps = 17/238 (7%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 Q + + + +LG+G V + + TG ++A K + + E ++L Sbjct: 4 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVL 61 Query: 239 EKVNSRFVVSLAYAYE--TKDALCLVLTLMNGGDLKFHIYHMGQA-GFPEARAVFYAAEI 295 +K+N + +V L E T L++ G L + A G PE+ + ++ Sbjct: 62 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 121 Query: 296 CCGLEDLHRERIVYRDLKPENIL--LDDHGH--IRISDLGLAVHVPEGQTIKGRVGTVGY 351 G+ L IV+R++KP NI+ + + G +++D G A + + + GT Y Sbjct: 122 VGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 181 Query: 352 MAPEVVK--------NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLV 401 + P++ + ++Y + D W++G Y G PF+ + + +EV + Sbjct: 182 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI 239 >4EUT-A nrPDB Length = 396 Score = 194 bits (493), Expect = 9e-50, Method: Composition-based stats. Identities = 51/238 (21%), Positives = 102/238 (42%), Gaps = 17/238 (7%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 Q + + + +LG+G V + + TG ++A K + + E ++L Sbjct: 4 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVL 61 Query: 239 EKVNSRFVVSLAYAYE--TKDALCLVLTLMNGGDLKFHIYHMGQA-GFPEARAVFYAAEI 295 +K+N + +V L E T L++ G L + A G PE+ + ++ Sbjct: 62 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 121 Query: 296 CCGLEDLHRERIVYRDLKPENIL--LDDHGH--IRISDLGLAVHVPEGQTIKGRVGTVGY 351 G+ L IV+R++KP NI+ + + G +++D G A + + + GT Y Sbjct: 122 VGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 181 Query: 352 MAPEVVK--------NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLV 401 + P++ + ++Y + D W++G Y G PF+ + + +EV + Sbjct: 182 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI 239 >2PMN-X nrPDB Length = 348 Score = 194 bits (492), Expect = 1e-49, Method: Composition-based stats. Identities = 74/342 (21%), Positives = 130/342 (38%), Gaps = 52/342 (15%) Query: 156 APFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACK 215 ++Y + IY N K+++ + N +R R L +G F ++ C+ K YA K Sbjct: 8 DILSNYSNLIYLN-----KYVKEKDKYINDYRIIRTLNQGKFNKIILCE--KDNKFYALK 60 Query: 216 KLEKKRIKKRKGEAM--------------ALNEKQILEKVNSRFVVSLAYAYETKDALCL 261 K EK ++K++ NE QI+ + + + ++ D + + Sbjct: 61 KYEKSLLEKKRDFTKSNNDKISIKSKYDDFKNELQIITDIKNEYCLTCEGIITNYDEVYI 120 Query: 262 VLTLMNGGDL------KFHIYHMGQAGFPEARAVFYAAEICCGLEDLH-RERIVYRDLKP 314 + M + F + P + +H + I +RD+KP Sbjct: 121 IYEYMENDSILKFDEYFFVLDKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKP 180 Query: 315 ENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE-RYTF-SPDWWALG 372 NIL+D +G +++SD G + ++ + + IKG GT +M PE NE Y D W+LG Sbjct: 181 SNILMDKNGRVKLSDFGESEYMVD-KKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLG 239 Query: 373 CLLYEMIAGQSPFQ-QRKKKIKREEVERLVKEVPEEYSERFSP---------------QA 416 LY M PF + + E P + + P + Sbjct: 240 ICLYVMFYNVVPFSLKISLVELFNNIRTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNED 299 Query: 417 RSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGA 458 L K+PAER+ ++ + +H N + L Sbjct: 300 IDFLKLFLRKNPAERI-----TSEDALKHEWLADTNIEDLRE 336 >3RAW-A nrPDB Length = 381 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 72/367 (19%), Positives = 129/367 (35%), Gaps = 86/367 (23%) Query: 163 DSIYFNRFLQWKWLERQ--------------PVTKNTFRQYRVLGKGGFGEVCACQVRAT 208 +++YF K R + + LG+G FG+V C A Sbjct: 16 ENLYFQSMQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHAR 75 Query: 209 GK-MYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF---VVSLAYAYETKDALCLVLT 264 GK A K + + K R+ + +N + +++ + V ++ + +C+ Sbjct: 76 GKSQVALKII-RNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFE 134 Query: 265 LMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDD--- 321 L+ G + + +P A ++C L LH ++ + DLKPENIL + Sbjct: 135 LL-GKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEF 193 Query: 322 ----------------HGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFS 365 + IR++D G A + + V T Y PEV+ + Sbjct: 194 ETLYNEHKSCEEKSVKNTSIRVADFGSATF--DHEHHTTIVATRHYRPPEVILELGWAQP 251 Query: 366 PDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEY----------------S 409 D W++GC+L+E G + FQ + + +E+++ +P Sbjct: 252 CDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVW 311 Query: 410 ERFSPQAR------------------------SLCSQLLCKDPAERLGCRGGSAREVKEH 445 + S R L ++L DPA+R+ + E H Sbjct: 312 DENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRI-----TLAEALLH 366 Query: 446 PLFKKLN 452 P F L Sbjct: 367 PFFAGLT 373 >5UNP-A nrPDB Length = 369 Score = 192 bits (489), Expect = 3e-49, Method: Composition-based stats. Identities = 73/350 (20%), Positives = 128/350 (36%), Gaps = 86/350 (24%) Query: 183 KNTFRQYRVLGKGGFGEVCACQ-VRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 + + LG+G FG V C R G A K ++ K + A E +LEK+ Sbjct: 33 QERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNV----EKYKEAARLEINVLEKI 88 Query: 242 N-----SRFV-VSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEI 295 N ++ + V + ++ +C+ L+ G + +P + A ++ Sbjct: 89 NEKDPDNKNLCVQMFDWFDYHGHMCISFELL-GLSTFDFLKDNNYLPYPIHQVRHMAFQL 147 Query: 296 CCGLEDLHRERIVYRDLKPENILLDDHGH-------------------IRISDLGLAVHV 336 C ++ LH ++ + DLKPENIL + + +R+ D G A Sbjct: 148 CQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATF- 206 Query: 337 PEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREE 396 + + V T Y APEV+ ++ D W++GC+++E G + FQ + Sbjct: 207 -DHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAM 265 Query: 397 VERLVKEVPE----------------------------------EYSERFSPQAR----- 417 +ER++ +P + +A Sbjct: 266 MERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQL 325 Query: 418 -SLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFK 466 L +L +PA+RL + E +HP F +L EPP K Sbjct: 326 FDLIESMLEYEPAKRL-----TLGEALQHPFFARL--------RAEPPNK 362 >4C59-A nrPDB Length = 340 Score = 191 bits (485), Expect = 7e-49, Method: Composition-based stats. Identities = 66/276 (23%), Positives = 106/276 (38%), Gaps = 36/276 (13%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV-NS 243 R RVL +GGF V Q +G+ YA K+L +K + + E ++K+ Sbjct: 28 RLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRA---IIQEVCFMKKLSGH 84 Query: 244 RFVVSLAYAYETKDA--------LCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEI 295 +V A L+ L G ++F + + + Sbjct: 85 PNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQT 144 Query: 296 CCGLEDLHRER--IVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIK---------- 343 C ++ +HR++ I++RDLK EN+LL + G I++ D G A + Sbjct: 145 CRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVE 204 Query: 344 ---GRVGTVGYMAPEVV---KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEV 397 R T Y PE++ N D WALGC+LY + Q PF+ K + Sbjct: 205 EEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKL----RI 260 Query: 398 ERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLG 433 +P ++ SL +L +P ERL Sbjct: 261 VNGKYSIPPHDTQY--TVFHSLIRAMLQVNPEERLS 294 >6NT9-A nrPDB Length = 742 Score = 191 bits (485), Expect = 8e-49, Method: Composition-based stats. Identities = 51/238 (21%), Positives = 102/238 (42%), Gaps = 17/238 (7%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 Q + + + +LG+G V + + TG ++A K + + E ++L Sbjct: 2 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVL 59 Query: 239 EKVNSRFVVSLAYAYE--TKDALCLVLTLMNGGDLKFHIYHMGQA-GFPEARAVFYAAEI 295 +K+N + +V L E T L++ G L + A G PE+ + ++ Sbjct: 60 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 119 Query: 296 CCGLEDLHRERIVYRDLKPENIL--LDDHGH--IRISDLGLAVHVPEGQTIKGRVGTVGY 351 G+ L IV+R++KP NI+ + + G +++D G A + + + GT Y Sbjct: 120 VGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEY 179 Query: 352 MAPEVVK--------NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLV 401 + P++ + ++Y + D W++G Y G PF+ + + +EV + Sbjct: 180 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI 237 >6O8B-A nrPDB Length = 665 Score = 190 bits (484), Expect = 1e-48, Method: Composition-based stats. Identities = 51/238 (21%), Positives = 102/238 (42%), Gaps = 17/238 (7%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 Q + + + +LG+G V + + TG ++A K + + E ++L Sbjct: 10 QSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVL 67 Query: 239 EKVNSRFVVSLAYAYE--TKDALCLVLTLMNGGDLKFHIYHMGQA-GFPEARAVFYAAEI 295 +K+N + +V L E T L++ G L + A G PE+ + ++ Sbjct: 68 KKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDV 127 Query: 296 CCGLEDLHRERIVYRDLKPENIL--LDDHGH--IRISDLGLAVHVPEGQTIKGRVGTVGY 351 G+ L IV+R++KP NI+ + + G +++D G A + + + GT Y Sbjct: 128 VGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEY 187 Query: 352 MAPEVVK--------NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLV 401 + P++ + ++Y + D W++G Y G PF+ + + +EV + Sbjct: 188 LHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI 245 >4G3E-A nrPDB Length = 352 Score = 190 bits (483), Expect = 1e-48, Method: Composition-based stats. Identities = 72/277 (25%), Positives = 115/277 (41%), Gaps = 33/277 (11%) Query: 175 WLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNE 234 W+ QP +G+G FGEV + + TG A KK+ + + E Sbjct: 75 WMTHQPR----------VGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVE--------E 116 Query: 235 KQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAE 294 ++S +V L A + + + L+ GG L I MG PE RA++Y + Sbjct: 117 LVACAGLSSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQMG--CLPEDRALYYLGQ 174 Query: 295 ICCGLEDLHRERIVYRDLKPENILLDDHG-HIRISDLGLAVHVPEGQTIKGRV------G 347 GLE LH RI++ D+K +N+LL G + D G A+ + K + G Sbjct: 175 ALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPG 234 Query: 348 TVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEE 407 T +MAPEVV + D W+ C++ M+ G P+ Q + ++ + E Sbjct: 235 TETHMAPEVVMGKPCDAKVDIWSSCCMMLHMLNGCHPWTQYFRGPLCLKIASEPPPI-RE 293 Query: 408 YSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKE 444 +P + L K+P R SA E++ Sbjct: 294 IPPSCAPLTAQAIQEGLRKEPVHR-----ASAMELRR 325 >2QKW-B nrPDB Length = 321 Score = 190 bits (482), Expect = 2e-48, Method: Composition-based stats. Identities = 58/233 (24%), Positives = 101/233 (43%), Gaps = 12/233 (5%) Query: 155 VAPFADYLDSIYFNRFLQW--KWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMY 212 D L S Y F + ++ + T N F ++G G FG+V +R G Sbjct: 9 TNSINDALSSSYLVPFESYRVPLVDLEEAT-NNFDHKFLIGHGVFGKVYKGVLR-DGAKV 66 Query: 213 ACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLK 272 A K ++ + +G E + L +VSL + ++ + L+ M G+LK Sbjct: 67 ALK---RRTPESSQGIEEFETEIETLSFCRHPHLVSLIGFCDERNEMILIYKYMENGNLK 123 Query: 273 FHIY--HMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDL 330 H+Y + + + GL LH I++RD+K NILLD++ +I+D Sbjct: 124 RHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTRAIIHRDVKSINILLDENFVPKITDF 183 Query: 331 GLAV---HVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA 380 G++ + + GT+GY+ PE R T D ++ G +L+E++ Sbjct: 184 GISKKGTELDQTHLSTVVKGTLGYIDPEYFIKGRLTEKSDVYSFGVVLFEVLC 236 >6EII-A nrPDB Length = 352 Score = 190 bits (482), Expect = 2e-48, Method: Composition-based stats. Identities = 74/308 (24%), Positives = 120/308 (38%), Gaps = 55/308 (17%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 ++ ++ R LG+G + EV + +I K + E +ILE + Sbjct: 59 QDDYQLVRKLGRGKYSEVFEAINITNNEK------VVVKILKPVKKKKIKREIKILENLR 112 Query: 243 S-RFVVSLAYAYETK--DALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 +++LA + LV +N D + + FY EI L Sbjct: 113 GGPNIITLADIVKDPVSRTPALVFEHVNNTD-----FKQLYQTLTDYDIRFYMYEILKAL 167 Query: 300 EDLHRERIVYRDLKPENILLD-DHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVV- 357 + H I++RD+KP N+++D +H +R+ D GLA GQ RV + + PE++ Sbjct: 168 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV 227 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKR----------EEVERLVKEVPEE 407 + Y +S D W+LGC+L MI + PF + E++ + + E Sbjct: 228 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 287 Query: 408 YSERF------------------------SPQARSLCSQLLCKDPAERLGCRGGSAREVK 443 RF SP+A +LL D RL +ARE Sbjct: 288 LDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRL-----TAREAM 342 Query: 444 EHPLFKKL 451 EHP F + Sbjct: 343 EHPYFYTV 350 >6HMD-A nrPDB Length = 365 Score = 189 bits (479), Expect = 4e-48, Method: Composition-based stats. Identities = 67/305 (21%), Positives = 116/305 (38%), Gaps = 55/305 (18%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 ++ ++ R LG+G + EV + +I K + E +ILE + Sbjct: 52 QDDYQLVRKLGRGKYSEVFEAINITNNER------VVVKILKPVKKKKIKREVKILENLR 105 Query: 243 S-RFVVSLAYAYETK--DALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 ++ L + LV +N D + + FY E+ L Sbjct: 106 GGTNIIKLIDTVKDPVSKTPALVFEYINNTD-----FKQLYQILTDFDIRFYMYELLKAL 160 Query: 300 EDLHRERIVYRDLKPENILLDD-HGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVV- 357 + H + I++RD+KP N+++D +R+ D GLA Q RV + + PE++ Sbjct: 161 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLV 220 Query: 358 KNERYTFSPDWWALGCLLYEMIAGQSP-FQQRKKKIKREEVERLVKE------------- 403 + Y +S D W+LGC+L MI + P F + + + +++ Sbjct: 221 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 280 Query: 404 --------------------VPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVK 443 + E SP+A L +LL D +RL +A+E Sbjct: 281 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL-----TAKEAM 335 Query: 444 EHPLF 448 EHP F Sbjct: 336 EHPYF 340 >4NEU-A nrPDB Length = 333 Score = 188 bits (478), Expect = 6e-48, Method: Composition-based stats. Identities = 71/283 (25%), Positives = 112/283 (39%), Gaps = 30/283 (10%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 F + L GGFG+V C R G M K + K EA L E +++ ++ Sbjct: 25 DFLESAELDSGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEA-LLEEAKMMNRLRHS 82 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 VV L + LV+ M G+L + EI G+ LH Sbjct: 83 RVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVK--GRIILEIIEGMCYLHG 140 Query: 305 ERIVYRDLKPENILLDDHGHIRISDLGLAVHV--------------PEGQTIKGRVGTVG 350 + ++++DLKPENIL+D+ HI+I+DLGLA T K GT+ Sbjct: 141 KGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLY 200 Query: 351 YMAPEVVK--NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEY 408 YMAPE + N + T D ++ +L+ + A + P++ I +++ +K Sbjct: 201 YMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYE---NAICEQQLIMCIKSGNRPD 257 Query: 409 SERFSP----QARSLCSQLLCKDPAERLGCRGGSAREVKEHPL 447 + + + SL +P R E K P Sbjct: 258 VDDITEYCPREIISLMKLCWEANPEARPTF--PGIEE-KFRPF 297 >2BUJ-A nrPDB Length = 317 Score = 186 bits (473), Expect = 2e-47, Method: Composition-based stats. Identities = 68/288 (23%), Positives = 114/288 (39%), Gaps = 30/288 (10%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI 222 +++YF + + + + LG+GGF V + G YA K++ Sbjct: 15 ENLYFQGHMVI-------IDNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRI---LC 64 Query: 223 KKRKGEAMALNEKQILEKVNSRFVVSLAYAYET----KDALCLVLTLMNGGDLKFHIYHM 278 +++ A E + N ++ L K L+L G L I + Sbjct: 65 HEQQDREEAQREADMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERL 124 Query: 279 GQAG--FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGL---- 332 G E + ++ IC GLE +H + +RDLKP NILL D G + DLG Sbjct: 125 KDKGNFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQA 184 Query: 333 ------AVHVPEGQTIKGRVGTVGYMAPEVVKNERY---TFSPDWWALGCLLYEMIAGQS 383 + Q + T+ Y APE+ + + D W+LGC+LY M+ G+ Sbjct: 185 CIHVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEG 244 Query: 384 PFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 P+ +K + + ++ S R S L + ++ DP +R Sbjct: 245 PYDMVFQKGDSVALA-VQNQLSIPQSPRHSSALWQLLNSMMTVDPHQR 291 >3LLT-A nrPDB Length = 360 Score = 186 bits (473), Expect = 2e-47, Method: Composition-based stats. Identities = 81/362 (22%), Positives = 125/362 (34%), Gaps = 88/362 (24%) Query: 163 DSIYFN---RFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEK 219 +++YF + + W ++ + N F R +G G FG V CQ K YA K + Sbjct: 12 ENLYFQGDDEIVHFSW-KKGMLLNNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVV-- 68 Query: 220 KRIKKRKGEAMALNEKQILEKVNSRFV-----VSLAYAYETKDALCLVLTLMNGGDLKFH 274 + IKK A E IL+K+ + + V + D +CL+ + G L Sbjct: 69 RNIKKYTRSAKI--EADILKKIQNDDINNNNIVKYHGKFMYYDHMCLIFEPL-GPSLYEI 125 Query: 275 IYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDD------------- 321 I GF Y EI L L + + + DLKPENILLDD Sbjct: 126 ITRNNYNGFHIEDIKLYCIEILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRV 185 Query: 322 ------------HGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWW 369 I++ D G A + + T Y APEV+ N + S D W Sbjct: 186 TDGKKIQIYRTKSTGIKLIDFGCATFKSDYH--GSIINTRQYRAPEVILNLGWDVSSDMW 243 Query: 370 ALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEE---------------------- 407 + GC+L E+ G F+ + +E +++ +P+ Sbjct: 244 SFGCVLAELYTGSLLFRTHEHMEHLAMMESIIQPIPKNMLYEATKTNGSKYVNKDELKLA 303 Query: 408 YSERFS--------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPL 447 + E S +L DP R S E+ +H Sbjct: 304 WPENASSINSIKHVKKCLPLYKIIKHELFCDFLYSILQIDPTLR-----PSPAELLKHKF 358 Query: 448 FK 449 + Sbjct: 359 LE 360 >5XVU-A nrPDB Length = 332 Score = 185 bits (471), Expect = 3e-47, Method: Composition-based stats. Identities = 67/322 (20%), Positives = 125/322 (38%), Gaps = 55/322 (17%) Query: 169 RFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGE 228 + + LE Q N + + +G+G + EV + A ++ K + Sbjct: 16 EYYDYDNLELQWNKPNRYEIMKKIGRGKYSEVFNGYDTECNRPCA------IKVLKPVKK 69 Query: 229 AMALNEKQILEKVNS-RFVVSLAYAYETK--DALCLVLTLMNGGDLKFHIYHMGQAGFPE 285 E +IL+ +N ++ L + L+ +N D + F + Sbjct: 70 KKIKREIKILQNLNGGPNIIKLLDIVKDPVTKTPSLIFEYINNID-----FKTLYPKFTD 124 Query: 286 ARAVFYAAEICCGLEDLHRERIVYRDLKPENILLD-DHGHIRISDLGLAVHVPEGQTIKG 344 +Y +I L+ H + I++RD+KP NI++D ++ IR+ GLA GQ Sbjct: 125 KDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNV 184 Query: 345 RVGTVGYMAPEVVKN-ERYTFSPDWWALGCLLYEMIAGQSPF-QQRKKKIKREEVER--- 399 RV + Y PE++ + + Y +S D W+LGC+L MI + PF + ++ + Sbjct: 185 RVASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLG 244 Query: 400 ---------------------LVKEVPEEYSERF---------SPQARSLCSQLLCKDPA 429 ++ E + F + L ++L D A Sbjct: 245 TEDLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHA 304 Query: 430 ERLGCRGGSAREVKEHPLFKKL 451 +R+ +E EHP F+++ Sbjct: 305 KRIAP-----KEAMEHPYFREV 321 >4FL3-A nrPDB Length = 635 Score = 184 bits (467), Expect = 9e-47, Method: Composition-based stats. Identities = 51/265 (19%), Positives = 103/265 (38%), Gaps = 16/265 (6%) Query: 175 WLERQPVTKNTFRQYRVLGKGGFGEVCACQV-RATGKMYACKKLEKKRIKKRKGEAMALN 233 +L+R+ +T + LG G FG V K+ K + L Sbjct: 364 YLDRKLLTLED----KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLA 419 Query: 234 EKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAA 293 E +++++++ ++V + E + + LV+ + G L ++ + + Sbjct: 420 EANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQ--NRHVKDKNIIELVH 476 Query: 294 EICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI----KGRVGTV 349 ++ G++ L V+RDL N+LL + +ISD GL+ + + V Sbjct: 477 QVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPV 536 Query: 350 GYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEY 408 + APE + +++ D W+ G L++E + GQ P++ K +E+ + Sbjct: 537 KWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERM---GC 593 Query: 409 SERFSPQARSLCSQLLCKDPAERLG 433 + L + D R G Sbjct: 594 PAGCPREMYDLMNLCWTYDVENRPG 618 >5WNO-A nrPDB Length = 330 Score = 183 bits (465), Expect = 2e-46, Method: Composition-based stats. Identities = 56/256 (21%), Positives = 101/256 (39%), Gaps = 17/256 (6%) Query: 187 RQYRVLGKGGFGEVCAC-----QVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 + + LG G FG V A + + A K + + + + L E + ++ Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDE----MLEEATNMFRL 80 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 ++ + D L +V G+L+ + + + V Y +I G++ Sbjct: 81 RHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFL-KLHKENLGAREQVLYCYQIASGMQY 139 Query: 302 LHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQ---TIKGRVGTVGYMAPEVVK 358 L ++R+V+RDL N+L+ H+ I+D GL+ + TIK + ++A E+ Sbjct: 140 LEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFS 199 Query: 359 NERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR 417 YT + D WA G +E+I GQSP+Q ++ + S Sbjct: 200 KHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNR---LSQPPNCSQDLY 256 Query: 418 SLCSQLLCKDPAERLG 433 + DP R G Sbjct: 257 QELLRCWMADPKSRPG 272 >2H34-A nrPDB Length = 309 Score = 183 bits (464), Expect = 2e-46, Method: Composition-based stats. Identities = 61/249 (24%), Positives = 107/249 (42%), Gaps = 5/249 (2%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 +R R++G+GG G+V + ++ A K + + E + ++ Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 VV + E L + + L+NG DL + G P RAV +I L+ H Sbjct: 96 VVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPP--RAVAIVRQIGSALDAAHAA 153 Query: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIK--GRVGTVGYMAPEVVKNERYT 363 +RD+KPENIL+ + D G+A + + + VGT+ YMAPE T Sbjct: 154 GATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSESHAT 213 Query: 364 FSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQL 423 + D +AL C+LYE + G P+Q + + + + + P ++ ++ Sbjct: 214 YRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPR-PSTVRPGIPVAFDAVIARG 272 Query: 424 LCKDPAERL 432 + K+P +R Sbjct: 273 MAKNPEDRY 281 >5C26-A nrPDB Length = 299 Score = 182 bits (463), Expect = 3e-46, Method: Composition-based stats. Identities = 51/265 (19%), Positives = 103/265 (38%), Gaps = 16/265 (6%) Query: 175 WLERQPVTKNTFRQYRVLGKGGFGEVCACQV-RATGKMYACKKLEKKRIKKRKGEAMALN 233 +L+R+ +T + LG G FG V K+ K + L Sbjct: 22 YLDRKLLTLED----KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLA 77 Query: 234 EKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAA 293 E +++++++ ++V + E + + LV+ + G L ++ + + Sbjct: 78 EANVMQQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQ--NRHVKDKNIIELVH 134 Query: 294 EICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI----KGRVGTV 349 ++ G++ L V+RDL N+LL + +ISD GL+ + + V Sbjct: 135 QVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPV 194 Query: 350 GYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEY 408 + APE + +++ D W+ G L++E + GQ P++ K +E+ + Sbjct: 195 KWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERM---GC 251 Query: 409 SERFSPQARSLCSQLLCKDPAERLG 433 + L + D R G Sbjct: 252 PAGCPREMYDLMNLCWTYDVENRPG 276 >5WNL-A nrPDB Length = 342 Score = 182 bits (461), Expect = 5e-46, Method: Composition-based stats. Identities = 59/272 (21%), Positives = 108/272 (39%), Gaps = 27/272 (9%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 F + +G GGFG+V + A K + R+ L E + +E R Sbjct: 21 EFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRER-MELLEEAKKMEMAKFR 79 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH- 303 +++ + + + + LV+ M G L+ + P E G+ LH Sbjct: 80 YILPVYGICQ--EPVGLVMEYMETGSLEKLL---ASEPLPWDLRFRIVHETAVGMNFLHC 134 Query: 304 -RERIVYRDLKPENILLDDHGHIRISDLGLAV----HVPEGQTIKGRVGTVGYMAPEVVK 358 +++ +LKP NILLD H H++ISD GLA ++ G GT+ Y+ PE ++ Sbjct: 135 MSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIR 194 Query: 359 NER--YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSP-- 414 + + D ++ +++ ++ + PF K + + ++VK E P Sbjct: 195 EKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHI--MMKVVKGHRPELPPICRPRP 252 Query: 415 ----QARSLCSQLLCKDPAERLGCRGGSAREV 442 L + DP R + +E+ Sbjct: 253 RACASLIGLMQRCWHADPQVR-----PTFQEI 279 >6HV0-A nrPDB Length = 416 Score = 181 bits (460), Expect = 5e-46, Method: Composition-based stats. Identities = 71/284 (25%), Positives = 116/284 (40%), Gaps = 33/284 (11%) Query: 185 TFRQYRVLGKGGFGE-VCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 +F VLG G G V + A K++ + E L E Sbjct: 9 SFCPKDVLGHGAEGTIVYRGMF--DNRDVAVKRILPECFSFADREVQLLRESD-----EH 61 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 V+ + + + + L L+ ++ A + GL LH Sbjct: 62 PNVIRYFCTEKDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPI-TLLQQTTSGLAHLH 119 Query: 304 RERIVYRDLKPENILL---DDHGHIR--ISDLGLAVHVPEGQTIKGRV----GTVGYMAP 354 IV+RDLKP NIL+ + HG I+ ISD GL + G+ R GT G++AP Sbjct: 120 SLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAP 179 Query: 355 EVVKN---ERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKE--VPEEY 408 E++ E T++ D ++ GC+ Y +I+ G PF + ++ + + PE++ Sbjct: 180 EMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKH 239 Query: 409 SERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 + AR L +++ DP +R SA+ V +HP F L Sbjct: 240 EDVI---ARELIEKMIAMDPQKR-----PSAKHVLKHPFFWSLE 275 >4PL5-B nrPDB Length = 435 Score = 180 bits (458), Expect = 9e-46, Method: Composition-based stats. Identities = 71/283 (25%), Positives = 115/283 (40%), Gaps = 31/283 (10%) Query: 185 TFRQYRVLGKGGFGE-VCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 +F VLG G G V + A K++ + E L E Sbjct: 28 SFCPKDVLGHGAEGTIVYKGMF--DNRDVAVKRILPECFSFADREVQLLRESD-----EH 80 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 V+ + + + + L L+ ++ A + GL LH Sbjct: 81 PNVIRYFCTEKDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPI-TLLHQTTSGLAHLH 138 Query: 304 RERIVYRDLKPENILL---DDHGHIR--ISDLGLAVHVPEGQTIKGRV----GTVGYMAP 354 IV+RDLKP NILL + HG I+ ISD GL + G+ R GT G++AP Sbjct: 139 SLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAP 198 Query: 355 EVVKN---ERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSE 410 E++ + T++ D ++ GC+ Y +I+ G PF K ++ + + +S+ Sbjct: 199 EMLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPF--GKSLQRQANILLGACNLDCFHSD 256 Query: 411 RFSPQ-ARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 + AR L +++ DP +R SA+ V +HP F L Sbjct: 257 KHEDVIARELIEKMIAMDPQQR-----PSAKHVLKHPFFWSLE 294 >5TE0-A nrPDB Length = 347 Score = 180 bits (457), Expect = 1e-45, Method: Composition-based stats. Identities = 67/272 (24%), Positives = 112/272 (41%), Gaps = 32/272 (11%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 + + VL +GGF V + + G A K++ + + E QI+ Sbjct: 16 IGRQQVTVDEVLAEGGFAIVFLVR-TSNGMKCALKRM---FVNNEHDLQVCKREIQIMRD 71 Query: 241 V-NSRFVVSLAYA----YETKD--ALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAA 293 + + +V + + D + +++ GG + + Q GF E + Sbjct: 72 LSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFC 131 Query: 294 EICCGLEDLHRER--IVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKG------- 344 + C + LH+ + I++RDLK ENILL D GH + D G A + + +G Sbjct: 132 DTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDE 191 Query: 345 --RVGTVGYMAPEVVK---NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVER 399 + T+ Y APE+V + T D WALGCLLY++ PF + + I Sbjct: 192 IKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGN--- 248 Query: 400 LVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 +P+ R+S L +L DP +R Sbjct: 249 --FTIPDN--SRYSQDMHCLIRYMLEPDPDKR 276 >5XD6-A nrPDB Length = 305 Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 55/249 (22%), Positives = 104/249 (41%), Gaps = 19/249 (7%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQ 236 E + +T N + ++G+G +G V ++ +GK A KKL+ ++ + L + Sbjct: 16 ELRDITDN-YGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLD----SSKQPDQEFLAQVS 69 Query: 237 ILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG-------FPEARAV 289 ++ ++ VV+L L G L ++ + V Sbjct: 70 MVSRLRQENVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRV 129 Query: 290 FYAAEICCGLEDLHRE---RIVYRDLKPENILLDDHGHIRISDLGLAVHVPE--GQTIKG 344 A GLE LH + +++RD+K N+LL D +I+D L+ P+ + Sbjct: 130 KIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHST 189 Query: 345 RV-GTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKE 403 RV GT GY APE + D ++ G +L E++ G+ P + ++ V + Sbjct: 190 RVLGTFGYHAPEYAMTGTLSTKSDVYSFGVVLLELLTGRKPVDHTLPRGQQSVVTWATPK 249 Query: 404 VPEEYSERF 412 + E+ ++ Sbjct: 250 LSEDKVKQC 258 >5IKW-A nrPDB Length = 310 Score = 179 bits (454), Expect = 3e-45, Method: Composition-based stats. Identities = 63/271 (23%), Positives = 107/271 (39%), Gaps = 31/271 (11%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 V ++ L +GGF V + G A K++ + + E I+++ Sbjct: 11 VGRHQVTLEESLAEGGFSTVFLVRTHG-GIRCALKRMYVNNMPDLN---VCKREITIMKE 66 Query: 241 V-NSRFVVSLAYAYETK--DALC---LVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAE 294 + + +V D + +++ G + + Q GF E + + Sbjct: 67 LSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCD 126 Query: 295 ICCGLEDLHRER--IVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKG-------- 344 C + LH+ + I++RDLK ENILL+D G+ + D G A + G Sbjct: 127 TCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEI 186 Query: 345 -RVGTVGYMAPEVVK---NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERL 400 + T+ Y APE++ + T D WALGCLLY++ PF + + I Sbjct: 187 KKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGN---- 242 Query: 401 VKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 +P+ R+S L +L DP R Sbjct: 243 -FTIPDN--SRYSRNIHCLIRFMLEPDPEHR 270 >3ZZW-A nrPDB Length = 289 Score = 179 bits (454), Expect = 3e-45, Method: Composition-based stats. Identities = 59/302 (19%), Positives = 111/302 (36%), Gaps = 44/302 (14%) Query: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATG-----KMYACKKLEKKRIKKRKGEAMA 231 + + ++ + R LG+ FG+V + + A K L+ K + E Sbjct: 2 KLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREE--F 59 Query: 232 LNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG--------- 282 +E + ++ VV L L ++ + + GDL + Sbjct: 60 RHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDR 119 Query: 283 -----FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVP 337 V A+I G+E L +V++DL N+L+ D +++ISDLGL V Sbjct: 120 TVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVY 179 Query: 338 EGQTIK---GRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIK 393 K + + +MAPE + +++ D W+ G +L+E+ + G P+ + Sbjct: 180 AADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDV 239 Query: 394 REEVE-RLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 E + R V P++ + P+ R P FK ++ Sbjct: 240 VEMIRNRQVLPCPDDCPAWVYALMIE----CWNEFPSRR--------------PRFKDIH 281 Query: 453 FK 454 + Sbjct: 282 SR 283 >4CRL-A nrPDB Length = 406 Score = 179 bits (453), Expect = 4e-45, Method: Composition-based stats. Identities = 69/342 (20%), Positives = 125/342 (36%), Gaps = 75/342 (21%) Query: 171 LQWKWLERQPVTKNTFRQYR-VLGKGGFGEVCACQVRATGKM--YACKKLEKKRIKKRKG 227 + K + ++ F +G+G +G V + + YA K++E I Sbjct: 8 FKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGIS---- 63 Query: 228 EAMALNEKQILEKVNSRFVVSLAYAYET--KDALCLVLTLMNGGDLKFHIY-------HM 278 A E +L ++ V+SL + + + L+ DL I + Sbjct: 64 -MSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEH-DLWHIIKFHRASKANK 121 Query: 279 GQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLD----DHGHIRISDLGLAV 334 P +I G+ LH +++RDLKP NIL+ + G ++I+D+G A Sbjct: 122 KPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFAR 181 Query: 335 H----VPEGQTIKGRVGTVGYMAPEVVKN-ERYTFSPDWWALGCLLYEMIAGQSPFQQRK 389 + + V T Y APE++ YT + D WA+GC+ E++ + F R+ Sbjct: 182 LFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQ 241 Query: 390 KKIKREEVERL--------------------VKEVPEE---------------------Y 408 + IK +K++PE Sbjct: 242 EDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYME 301 Query: 409 SERFSPQAR--SLCSQLLCKDPAERLGCRGGSAREVKEHPLF 448 + P ++ L +LL DP +R+ ++ + + P F Sbjct: 302 KHKVKPDSKAFHLLQKLLTMDPIKRI-----TSEQAMQDPYF 338 >3QD2-B nrPDB Length = 332 Score = 178 bits (451), Expect = 8e-45, Method: Composition-based stats. Identities = 63/338 (18%), Positives = 123/338 (36%), Gaps = 83/338 (24%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 F + +G+GGFG V + + YA K++ + + E + L K+ Sbjct: 7 DFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPN--RELAREKVMREVKALAKLEHP 64 Query: 245 FV---------------------------------------------VSLAYAYETKD-- 257 + + + TK+ Sbjct: 65 GIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTV 124 Query: 258 ----------ALCLVLTLMNGGDLKFHIYHMGQAGFPEARA-VFYAAEICCGLEDLHRER 306 L + + L +LK + E + +I +E LH + Sbjct: 125 GQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKG 184 Query: 307 IVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQ-------------TIKGRVGTVGYMA 353 +++RDLKP NI +++ D GL + + + T G+VGT YM+ Sbjct: 185 LMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMS 244 Query: 354 PEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFS 413 PE + Y+ D ++LG +L+E++ F + ++++ R +K P +++++ Sbjct: 245 PEQIHGNNYSHKVDIFSLGLILFELLYS---FSTQMERVRIITDVRNLK-FPLLFTQKY- 299 Query: 414 PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 PQ + +L P ER A ++ E+ +F+ L Sbjct: 300 PQEHMMVQDMLSPSPTER-----PEATDIIENAIFENL 332 >5AR8-A nrPDB Length = 326 Score = 177 bits (449), Expect = 1e-44, Method: Composition-based stats. Identities = 58/292 (19%), Positives = 106/292 (36%), Gaps = 18/292 (6%) Query: 158 FADYLDSIYFNRFLQWKWLERQP-VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKK 216 D +++YF P + + R L +G G V + + A K Sbjct: 5 DDDDKENLYFQGMNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKH 64 Query: 217 LEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIY 276 L L E +IL K +++ + + L +V M G L ++ Sbjct: 65 LHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLH 124 Query: 277 HMGQAG-FPEARAVFYAAEICCGLEDLHRE--RIVYRDLKPENILLDDHGHIRISDLGLA 333 + EI G+ LH +++ DLK +NILLD+ H++I+D GL+ Sbjct: 125 RKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLS 184 Query: 334 V------HVPEGQTIKGRVGTVGYMAPEVV---KNERYTFSPDWWALGCLLYEMIAGQSP 384 GT+ YM PE + R + D ++ + +E+++ + P Sbjct: 185 KWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQP 244 Query: 385 FQQRKKKIK-----REEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 F+ ++ + ++ E Y + SL ++P ER Sbjct: 245 FEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDER 296 >2JD5-A nrPDB Length = 373 Score = 177 bits (449), Expect = 1e-44, Method: Composition-based stats. Identities = 67/341 (19%), Positives = 122/341 (35%), Gaps = 78/341 (22%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEK 235 + +P + R LG G F V + A K + ++ E +E Sbjct: 11 FKGEPYKDARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAE----DEI 66 Query: 236 QILEKVNSR-----------FVVSLAYAYETKD----ALCLVLTLMNGGDLKFHIYHMGQ 280 ++L++VN ++ L + K + +V ++ G +L I Sbjct: 67 KLLQRVNDADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVL-GENLLALIKKYEH 125 Query: 281 AGFPEARAVFYAAEICCGLEDLHRE-RIVYRDLKPENILLD------DHGHIRISDLGLA 333 G P + ++ GL+ +HR I++ D+KPEN+L++ + I+I+DLG A Sbjct: 126 RGIPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNA 185 Query: 334 VHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQR----- 388 E + T Y +PEV+ + D W+ CL++E+I G F+ Sbjct: 186 CWYDEH--YTNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSY 243 Query: 389 -KKKIKREEVERLVKEVPE--------------------------------------EYS 409 K ++ L+ E+P ++S Sbjct: 244 TKDDDHIAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFS 303 Query: 410 ERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 + + + S +L DP +R A + HP K Sbjct: 304 KDEAKEISDFLSPMLQLDPRKR-----ADAGGLVNHPWLKD 339 >6BFN-A nrPDB Length = 342 Score = 175 bits (444), Expect = 5e-44, Method: Composition-based stats. Identities = 53/239 (22%), Positives = 95/239 (39%), Gaps = 18/239 (7%) Query: 173 WKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKK-RIKKRKGEAMA 231 W E T N F + +G+GGFG V +R T +YA K+L++ ++ + Sbjct: 12 WPLCEISRGTHN-FSEELKIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSF 68 Query: 232 LNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQ--AGFPEARAV 289 L E + L + +V A CLV + G L+ ++ Q + + Sbjct: 69 LTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRL 128 Query: 290 FYAAEICCGLEDLH--RERIVYRDLKPENILLDDHGHIRISDLGLAV----------HVP 337 ++ LH +++ D+K N+LLD+ ++ D GLA Sbjct: 129 DILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSS 188 Query: 338 EGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREE 396 + GT+ Y+ E +K R D ++ G ++ E +AGQ + + K + Sbjct: 189 MVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLK 247 >3LMG-A nrPDB Length = 344 Score = 175 bits (443), Expect = 5e-44, Method: Composition-based stats. Identities = 46/226 (20%), Positives = 89/226 (39%), Gaps = 12/226 (5%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGK----MYACKKLEKKRIKKRKGEAMALNEKQILEK 240 R+ +VLG G FG V G+ K +E K R+ + + Sbjct: 32 ELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDK--SGRQSFQAVTDHMLAIGS 89 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 ++ +V L +L LV + G L H+ + + + +I G+ Sbjct: 90 LDHAHIVRLLGLC-PGSSLQLVTQYLPLGSLLDHVRQH-RGALGPQLLLNWGVQIAKGMY 147 Query: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT---IKGRVGTVGYMAPEVV 357 L +V+R+L N+LL ++++D G+A +P + +MA E + Sbjct: 148 YLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESI 207 Query: 358 KNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVK 402 +YT D W+ G ++E++ G P+ + + +E+ + Sbjct: 208 HFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGER 253 >4LQP-A nrPDB Length = 508 Score = 174 bits (442), Expect = 7e-44, Method: Composition-based stats. Identities = 59/169 (34%), Positives = 91/169 (53%), Gaps = 2/169 (1%) Query: 172 QWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMA 231 Q+ L R ++ F +V+GKG FGEV Q + TGK+YA K L K + K+ A Sbjct: 90 QFLRLRRTRLSLEDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHV 149 Query: 232 LNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFY 291 E+ +L +S +VVSL Y+++ L L++ + GGDL + F E FY Sbjct: 150 KAERDVLAGSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRW--QLFTEDVTRFY 207 Query: 292 AAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQ 340 AE +E +H+ ++R +KP+NIL+D GHI++SD GL+ + Sbjct: 208 MAECILAIETIHKLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTH 256 Score = 139 bits (350), Expect = 3e-33, Method: Composition-based stats. Identities = 39/144 (27%), Positives = 65/144 (45%), Gaps = 4/144 (2%) Query: 343 KGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVK 402 VGT Y+APE+ + Y DWW+LG ++YE + G PF + ++ + Sbjct: 321 YSTVGTPDYIAPEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQ 380 Query: 403 EVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLE 462 + S +A L +LL +RLG R G A E+K HP F+ +++ + +E Sbjct: 381 TLQFPDDIHISYEAEDLIRRLLTH-ADQRLG-RHGGADEIKSHPFFRGVDWNTI--RQVE 436 Query: 463 PPFKPDPQAIYCKDVLDIEQFSTV 486 P+ P +I ++ V Sbjct: 437 APYIPKLSSITDTRFFPTDELENV 460 >5VC6-A nrPDB Length = 289 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 69/285 (24%), Positives = 105/285 (36%), Gaps = 40/285 (14%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV-NS 243 F + +G G FG V C R G +YA K+ KK + E AL E + Sbjct: 12 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKR-SKKPLAGSVDEQNALREVYAHAVLGQH 70 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQ--AGFPEARAVFYAAEICCGLED 301 VV A+ D + + NGG L I + + F EA ++ GL Sbjct: 71 SHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRY 130 Query: 302 LHRERIVYRDLKPENILL-------------DDHG------HIRISDLGLAVHVPEGQTI 342 +H +V+ D+KP NI + D+ +I DLG HV + Sbjct: 131 IHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLG---HVTRISSP 187 Query: 343 KGRVGTVGYMAPEVVKNERYTF--SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERL 400 + G ++A EV++ E YT D +AL + AG P + + RL Sbjct: 188 QVEEGDSRFLANEVLQ-ENYTHLPKADIFALALTV-VCAAGAEPLPRNGDQWHEIRQGRL 245 Query: 401 VKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEH 445 + S + L ++ DP R SA + +H Sbjct: 246 -----PRIPQVLSQEFTELLKVMIHPDPERR-----PSAMALVKH 280 >4IAN-A nrPDB Length = 358 Score = 172 bits (437), Expect = 3e-43, Method: Composition-based stats. Identities = 68/336 (20%), Positives = 125/336 (37%), Gaps = 76/336 (22%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRAT-GKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 V + Y G+G F V + A + A K + + ++ G L E + L Sbjct: 26 EVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTG----LKELEFL 81 Query: 239 EKVNSR------FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQA-GFPEARAVFY 291 +K+N + L + K LCLV ++ +L+ + G+ G Y Sbjct: 82 KKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSM-NLREVLKKYGKDVGLHIKAVRSY 140 Query: 292 AAEICCGLEDLHRERIVYRDLKPENILLDDHGHI-RISDLGLAVHVPEGQTIKGRVGTVG 350 + ++ L+ L R I++ D+KP+NIL+++ I ++ D G A HV + I + + Sbjct: 141 SQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADND-ITPYLVSRF 199 Query: 351 YMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEY-- 408 Y APE++ + Y + D W++GC LYE+ G+ F + + L ++P + Sbjct: 200 YRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIR 259 Query: 409 -----SERFSPQA-------------------------RSLCSQL--------------- 423 + F + L + L Sbjct: 260 KGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVH 319 Query: 424 ---------LCKDPAERLGCRGGSAREVKEHPLFKK 450 L DPA+R+ S + +H ++ Sbjct: 320 QLKDLLDQILMLDPAKRI-----SINQALQHAFIQE 350 >5VDK-A nrPDB Length = 297 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 65/276 (23%), Positives = 105/276 (38%), Gaps = 37/276 (13%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV- 241 + F + +G G FG V C R G +YA K+ K + E AL+E + Sbjct: 14 EKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKR-SMKTFTELSNENSALHEVYAHAVLG 72 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAG--FPEARAVFYAAEICCGL 299 + VV ++ D + + NGG L+ I ++G F E + +I GL Sbjct: 73 HHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGL 132 Query: 300 EDLHRERIVYRDLKPENILLDDHGH-----------------------IRISDLGLAVHV 336 +H +V+ D+KP NI + +I DLG A + Sbjct: 133 NYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSI 192 Query: 337 PEGQTIKGRVGTVGYMAPEVVKNE-RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKRE 395 K G ++A E+++ + R+ D +ALG + + AG Sbjct: 193 ---NKPKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIA-VAAGAESLPTNGAAWHHI 248 Query: 396 EVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 +VP+E SE FS SL ++ D +R Sbjct: 249 RKGNF-PDVPQELSESFS----SLLKNMIQPDAEQR 279 >3Q4U-A nrPDB Length = 301 Score = 169 bits (427), Expect = 5e-42, Method: Composition-based stats. Identities = 66/301 (21%), Positives = 102/301 (33%), Gaps = 58/301 (19%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 Q +GKG +GEV + G+ A K + E E ++ Sbjct: 3 QRTVARDITLLECVGKGRYGEVWRGSWQ--GENVAVKIF------SSRDEKSWFRETELY 54 Query: 239 E--KVNSRFVVSLAYAYETKDA----LCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYA 292 + ++ + T L L+ G L ++ + Sbjct: 55 NTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQL---TTLDTVSCLRIV 111 Query: 293 AEICCGLEDLH--------RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT--- 341 I GL LH + I +RDLK +NIL+ +G I+DLGLAV + Sbjct: 112 LSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLD 171 Query: 342 --IKGRVGTVGYMAPEVVKN-------ERYTFSPDWWALGCLLYEMIAG----------Q 382 RVGT YMAPEV+ + Y D WA G +L+E+ + Sbjct: 172 VGNNPRVGTKRYMAPEVLDETIQVDCFDSY-KRVDIWAFGLVLWEVARRMVSNGIVEDYK 230 Query: 383 SPFQQRKKKIKREEVERLV-------KEVPEEYSER--FSPQARSLCSQLLCKDPAERLG 433 PF E R V +P + + A+ L + ++P+ RL Sbjct: 231 PPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAK-LMKECWYQNPSARLT 289 Query: 434 C 434 Sbjct: 290 A 290 >4LFI-A nrPDB Length = 374 Score = 168 bits (426), Expect = 6e-42, Method: Composition-based stats. Identities = 60/369 (16%), Positives = 118/369 (31%), Gaps = 92/369 (24%) Query: 154 SVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYA 213 + DY +++ + +G+G + EV + Sbjct: 21 RTEEYWDYENTVI-----------DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIV 69 Query: 214 C-----------------------KKLEKKRIKKRKGEAMALNEKQILE----------K 240 +K+ + +K + ++ +L+ Sbjct: 70 IKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPH 129 Query: 241 VNSRFVVSLAYAYETK--DALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 ++ L + LV ++ D + + + FY E+ Sbjct: 130 NGHANIIHLFDIIKDPISKTPALVFEYVDNVD-----FRILYPKLTDLEIRFYMFELLKA 184 Query: 299 LEDLHRERIVYRDLKPENILLDD-HGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVV 357 L+ H I++RD+KP N+++D + +R+ D GLA RV + + PE++ Sbjct: 185 LDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELL 244 Query: 358 -KNERYTFSPDWWALGCLLYEMIAGQSP-FQQRKKKIKREEVERLVK------------- 402 Y +S D W+ G +L MI + P F + ++ +++ Sbjct: 245 VDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEI 304 Query: 403 EVPEEY----------SERF----------SPQARSLCSQLLCKDPAERLGCRGGSAREV 442 +P E+ RF + + L LL D ERL +A+E Sbjct: 305 TLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERL-----TAKEA 359 Query: 443 KEHPLFKKL 451 HP F + Sbjct: 360 MGHPWFAPI 368 >3MDY-A nrPDB Length = 337 Score = 167 bits (423), Expect = 1e-41, Method: Composition-based stats. Identities = 68/299 (22%), Positives = 107/299 (35%), Gaps = 54/299 (18%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 Q + + +GKG +GEV + R G+ A K EA E +I Sbjct: 32 QRTIAKQIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVFF------TTEEASWFRETEIY 83 Query: 239 EKV--NSRFVVSLAYAYETKD----ALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYA 292 + V ++ A L L+ G L ++ + A Sbjct: 84 QTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKS---TTLDAKSMLKLA 140 Query: 293 AEICCGLEDLH--------RERIVYRDLKPENILLDDHGHIRISDLGLA-VHVPEGQTI- 342 GL LH + I +RDLK +NIL+ +G I+DLGLA + + + Sbjct: 141 YSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVD 200 Query: 343 ---KGRVGTVGYMAPEVV---KNERYTFS---PDWWALGCLLYEMIAG----------QS 383 RVGT YM PEV+ N + S D ++ G +L+E+ Q Sbjct: 201 IPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQL 260 Query: 384 PFQQRKKKIKREEVER---LVKEVPEEYSERFSPQAR-----SLCSQLLCKDPAERLGC 434 P+ E R +K++ + R+S L ++ +PA RL Sbjct: 261 PYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTA 319 >3SV0-A nrPDB Length = 483 Score = 165 bits (419), Expect = 3e-41, Method: Composition-based stats. Identities = 53/240 (22%), Positives = 92/240 (38%), Gaps = 25/240 (10%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQIL 238 +P N FR R +G G FGE+ T + A K K + L E +I Sbjct: 2 EPRVGNKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHPQ-----LLYESKIY 56 Query: 239 EKVNS----RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAE 294 + V D LV+ L+ G L+ +++ + A + Sbjct: 57 RILQGGTGIPN-VRWFGV--EGDYNVLVMDLL-GPSLED-LFNFCSRKLSLKTVLMLADQ 111 Query: 295 ICCGLEDLHRERIVYRDLKPENILLD---DHGHIRISDLGLAVHVPEGQTI--------K 343 + +E +H + ++RD+KP+N L+ + I D GLA + T K Sbjct: 112 MINRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENK 171 Query: 344 GRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKE 403 GT Y + + D +LG +L + G P+Q K K+++ E++ ++ Sbjct: 172 NLTGTARYASVNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISEK 231 >4M66-A nrPDB Length = 325 Score = 165 bits (418), Expect = 4e-41, Method: Composition-based stats. Identities = 61/251 (24%), Positives = 101/251 (40%), Gaps = 27/251 (10%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 V++ ++ +GKGGFG V R A K + K+I E + + Sbjct: 17 VSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISW---------EVKAMVN 67 Query: 241 VNSRFVVSLAYAYETKDALC-----LVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEI 295 + + V+ L E LV M G L + +A P E+ Sbjct: 68 LRNENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQ--PEAPRPWPLLCRLLQEV 125 Query: 296 CCGLEDLHR--ERIVYRDLKPENILLDDHGHIRISDLGLAVH-------VPEGQTIKGRV 346 G+ LH +++RDLKP NILLD H +++D GL+ G + Sbjct: 126 VLGMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSG 185 Query: 347 GTVGYMAPEVVK--NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEV 404 GT+ Y+ PE++ N + + + D ++ G L++ ++AG+ K + RE V Sbjct: 186 GTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGREAELVDKTSLIRETVCDRQSRP 245 Query: 405 PEEYSERFSPQ 415 P SP+ Sbjct: 246 PLTELPPGSPE 256 >3MY0-A nrPDB Length = 305 Score = 165 bits (417), Expect = 5e-41, Method: Composition-based stats. Identities = 63/290 (21%), Positives = 97/290 (33%), Gaps = 54/290 (18%) Query: 188 QYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE--KVNSRF 245 +GKG +GEV G+ A K + E E +I + Sbjct: 12 LVECVGKGRYGEVWRGLWH--GESVAVKIF------SSRDEQSWFRETEIYNTVLLRHDN 63 Query: 246 VVSLAYAYETK----DALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 ++ + T L L+ G L + + A+ A CGL Sbjct: 64 ILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQ---RQTLEPHLALRLAVSAACGLAH 120 Query: 302 LH--------RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI-----KGRVGT 348 LH + I +RD K N+L+ + I+DLGLAV +G RVGT Sbjct: 121 LHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGT 180 Query: 349 VGYMAPEVVKNERYT------FSPDWWALGCLLYEMIAG----------QSPFQQRKKKI 392 YMAPEV+ + T D WA G +L+E+ + PF Sbjct: 181 KRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPND 240 Query: 393 KREEVERLVKEVPEEYS--------ERFSPQARSLCSQLLCKDPAERLGC 434 E + V V ++ + + + +P+ RL Sbjct: 241 PSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTA 290 >2Y4I-B nrPDB Length = 319 Score = 165 bits (417), Expect = 6e-41, Method: Composition-based stats. Identities = 52/272 (19%), Positives = 107/272 (39%), Gaps = 23/272 (8%) Query: 175 WLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNE 234 +L+ + ++GKG FG+V + A + ++ +R E Sbjct: 24 FLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHG---EVAIRLIDIER-DNEDQLKAFKRE 79 Query: 235 KQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAE 294 + VV A + L ++ +L G L + + + A E Sbjct: 80 VMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRD-AKIVLDVNKTRQIAQE 138 Query: 295 ICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGL---AVHVPEG---QTIKGRVGT 348 I G+ LH + I+++DLK +N+ D +G + I+D GL + + G ++ + G Sbjct: 139 IVKGMGYLHAKGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRIQNGW 197 Query: 349 VGYMAPEVVKN---------ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVER 399 + ++APE+++ ++ D +ALG + YE+ A + PF+ + + ++ Sbjct: 198 LCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGT 257 Query: 400 LVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 +K P + + + ER Sbjct: 258 GMK--PNLSQIGMGKEISDILLFCWAFEQEER 287 >5L2Q-C nrPDB Length = 320 Score = 165 bits (417), Expect = 6e-41, Method: Composition-based stats. Identities = 69/282 (24%), Positives = 116/282 (41%), Gaps = 45/282 (15%) Query: 201 CACQVRATGKMYACKKLEKKR--------IKKRKGEAMALNEKQILEKVN-SRFVVSLAY 251 C + T Y K L + ++R+G+ + E +L ++ VV Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 252 AYET------------------KDALCLVLTLMNGGDLKF--------HIYHMGQAGFPE 285 ++ K +CLVL + D Y + + E Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 286 ARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGH-IRISDLGLAVHV-PEGQTIK 343 V ++ +E LH++ IV+RDLK N++L+ H I I++ L H+ EG +K Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLK 212 Query: 344 GRVGTVGYMAPEVVKNERYTFS-PDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVK 402 + G+ Y++P+V+ Y D WALG +L+ M+ GQ PF + +++ Sbjct: 213 DQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEY 272 Query: 403 EVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKE 444 +PE+ R S L +LL DP +RL A +V E Sbjct: 273 TIPED--GRVSENTVCLIRKLLVLDPQQRLA-----AADVLE 307 >2WTK-B nrPDB Length = 373 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 59/325 (18%), Positives = 106/325 (32%), Gaps = 70/325 (21%) Query: 186 FRQYRVLGKGGFG---EVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 + V+GKG F V + + TG+ +++ + E + + N Sbjct: 11 YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSNEM-VTFLQGELHVSKLFN 68 Query: 243 SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 +V + + L +V + M G K I G E + + L+ + Sbjct: 69 HPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYI 128 Query: 303 HRERIVYRDLKPENILLDDHGHIRISDLGLAVHVP----------EGQTIKGRVGTVGYM 352 H V+R +K +IL+ G + +S GL ++ K V + ++ Sbjct: 129 HHMGYVHRSVKASHILISVDGKVYLS--GLRSNLSMISHGQRQRVVHDFPKYSVKVLPWL 186 Query: 353 APEVVKN--ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVP----- 405 +PEV++ + Y D +++G E+ G PF+ +E+L VP Sbjct: 187 SPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQML--LEKLNGTVPCLLDT 244 Query: 406 ---------------------------------------EEYSERFSPQARSLCSQLLCK 426 Y FSP Q L + Sbjct: 245 STIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQR 304 Query: 427 DPAERLGCRGGSAREVKEHPLFKKL 451 +P R SA + H FK++ Sbjct: 305 NPDAR-----PSASTLLNHSFFKQI 324 >6DC0-A nrPDB Length = 292 Score = 161 bits (407), Expect = 9e-40, Method: Composition-based stats. Identities = 54/257 (21%), Positives = 100/257 (38%), Gaps = 25/257 (9%) Query: 200 VCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDAL 259 V TG+ CK K + + + L + + + + Sbjct: 22 VSRALCIHTGRELRCKVFPIKHYQDKIRPYIQL--------PSHSNITGIVEVILGETKA 73 Query: 260 CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILL 319 + + GD+ ++ + E A +I + H+ IV DLK + Sbjct: 74 YVFFEK-DFGDMHSYVRSRKR--LREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVF 130 Query: 320 --DDHGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKN-ERYTFSP-DWWALGCL 374 ++ +R+ L + E + + G Y++PE++ Y+ D W+LG + Sbjct: 131 STEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVM 190 Query: 375 LYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGC 434 LY ++ G+ PF ++ R +PE SP+AR L LL ++P+ERL Sbjct: 191 LYTLLVGRYPFHDSDPSALFSKIRRGQFCIPE----HISPKARCLIRSLLRREPSERL-- 244 Query: 435 RGGSAREVKEHPLFKKL 451 +A E+ HP F+ + Sbjct: 245 ---TAPEILLHPWFESV 258 >5CEK-A nrPDB Length = 263 Score = 161 bits (407), Expect = 9e-40, Method: Composition-based stats. Identities = 54/257 (21%), Positives = 100/257 (38%), Gaps = 25/257 (9%) Query: 200 VCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDAL 259 V TG+ CK K + + + L + + + + Sbjct: 25 VSRALCIHTGRELRCKVFPIKHYQDKIRPYIQL--------PSHSNITGIVEVILGETKA 76 Query: 260 CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILL 319 + + GD+ ++ + E A +I + H+ IV DLK + Sbjct: 77 YVFFEK-DFGDMHSYVRSRKR--LREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVF 133 Query: 320 --DDHGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKN-ERYTFSP-DWWALGCL 374 ++ +R+ L + E + + G Y++PE++ Y+ D W+LG + Sbjct: 134 STEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVM 193 Query: 375 LYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGC 434 LY ++ G+ PF ++ R +PE SP+AR L LL ++P+ERL Sbjct: 194 LYTLLVGRYPFHDSDPSALFSKIRRGQFCIPE----HISPKARCLIRSLLRREPSERL-- 247 Query: 435 RGGSAREVKEHPLFKKL 451 +A E+ HP F+ + Sbjct: 248 ---TAPEILLHPWFESV 261 >4TN6-A nrPDB Length = 318 Score = 161 bits (407), Expect = 1e-39, Method: Composition-based stats. Identities = 53/233 (22%), Positives = 95/233 (40%), Gaps = 17/233 (7%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 N +R R +G G FG++ A G+ A K LE + K + + K + V Sbjct: 5 VGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIK-LECVKTKHPQLHIESKIYKMMQGGV 63 Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 + + D +V+ L+ G L+ +++ F + A ++ +E Sbjct: 64 GIPTI---RWCGAEGDYNVMVMELL-GPSLED-LFNFCSRKFSLKTVLLLADQMISRIEY 118 Query: 302 LHRERIVYRDLKPENILL---DDHGHIRISDLGLAVHVPEGQTI--------KGRVGTVG 350 +H + ++RD+KP+N L+ + I D GLA + +T K GT Sbjct: 119 IHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTAR 178 Query: 351 YMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKE 403 Y + + D +LG +L G P+Q K KR++ ER+ ++ Sbjct: 179 YASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEK 231 >2X7G-A nrPDB Length = 389 Score = 160 bits (404), Expect = 2e-39, Method: Composition-based stats. Identities = 65/370 (17%), Positives = 111/370 (30%), Gaps = 116/370 (31%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN-- 242 + R LG G F V C + A K ++ + AL+E ++L+ V Sbjct: 32 RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK----SAQHYTETALDEIKLLKCVRES 87 Query: 243 ---SRF---VVSLAYAYETKD----ALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYA 292 VV L ++ +C+V ++ LK+ I G P Sbjct: 88 DPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKS-NYQGLPVRCVKSII 146 Query: 293 AEICCGLEDLHRE-RIVYRDLKPENILL-------------------------------- 319 ++ GL+ LH + +I++ D+KPENIL+ Sbjct: 147 RQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVST 206 Query: 320 ---------------DDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTF 364 D ++I+DLG A V + + T Y + EV+ Y+ Sbjct: 207 APAADLLVNPLDPRNADKIRVKIADLGNACWV--HKHFTEDIQTRQYRSIEVLIGAGYST 264 Query: 365 SPDWWALGCLLYEMIAGQSPFQQRK------KKIKREEVERLVKEVPEEY---------- 408 D W+ C+ +E+ G F+ + + L+ +P + Sbjct: 265 PADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREF 324 Query: 409 ----------------------------SERFSPQARSLCSQLLCKDPAERLGCRGGSAR 440 + Q +L P +R SA Sbjct: 325 FNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKR-----ASAG 379 Query: 441 EVKEHPLFKK 450 E HP Sbjct: 380 ECLRHPWLNS 389 >1PY5-A nrPDB Length = 326 Score = 159 bits (403), Expect = 2e-39, Method: Composition-based stats. Identities = 60/245 (24%), Positives = 88/245 (35%), Gaps = 46/245 (18%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE--KVNSRFVVSL 249 +GKG FGEV + R G+ A K + E E +I + + ++ Sbjct: 37 IGKGRFGEVWRGKWR--GEEVAVKIF------SSREERSWFREAEIYQTVMLRHENILGF 88 Query: 250 AYAYETKD----ALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH-- 303 A + L LV G L ++ + + A GL LH Sbjct: 89 IAADNKDNGTWTQLWLVSDYHEHGSLFDYL---NRYTVTVEGMIKLALSTASGLAHLHME 145 Query: 304 ------RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI-----KGRVGTVGYM 352 + I +RDLK +NIL+ +G I+DLGLAV RVGT YM Sbjct: 146 IVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYM 205 Query: 353 APEVVKNE------RYTFSPDWWALGCLLYEMIAG----------QSPFQQRKKKIKREE 396 APEV+ + D +A+G + +E+ Q P+ E Sbjct: 206 APEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVE 265 Query: 397 VERLV 401 R V Sbjct: 266 EMRKV 270 >4WUA-A nrPDB Length = 401 Score = 158 bits (400), Expect = 5e-39, Method: Composition-based stats. Identities = 71/406 (17%), Positives = 119/406 (29%), Gaps = 120/406 (29%) Query: 151 EYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGK 210 E L + Y ++ + + R LG G F V K Sbjct: 10 EILGSDDDEQEDPNDYCKGGYHL--VKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKK 67 Query: 211 MYACKKLEKKRIKKRKGEAMALNEKQILEKV-----NSRF---VVSLAYAYE----TKDA 258 A K ++ AL+E ++L+ V N VV L ++ Sbjct: 68 FVAMKVVK----SAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTH 123 Query: 259 LCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE-RIVYRDLKPENI 317 +C+V ++ LK+ I G P ++ GL+ LH + RI++ D+KPENI Sbjct: 124 ICMVFEVLGHHLLKWIIKS-NYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENI 182 Query: 318 LLD-------------------------------------------------DHGHIRIS 328 LL + ++I+ Sbjct: 183 LLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPATAGNFLVNPLEPKNAEKLKVKIA 242 Query: 329 DLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQR 388 DLG A V + + T Y + EV+ Y D W+ C+ +E+ G F+ Sbjct: 243 DLGNACWV--HKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPH 300 Query: 389 K------KKIKREEVERLVKEVPE------------------------------------ 406 + + L+ +VP Sbjct: 301 SGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVE 360 Query: 407 --EYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 E+S+ + +L P +R +A E HP Sbjct: 361 KYEWSQEEAAGFTDFLLPMLELIPEKR-----ATAAECLRHPWLNS 401 >4BTK-A nrPDB Length = 337 Score = 158 bits (399), Expect = 7e-39, Method: Composition-based stats. Identities = 54/246 (21%), Positives = 98/246 (39%), Gaps = 24/246 (9%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 V K+ ++ + +G GGFGE+ T + A K ++ + + E +L+K Sbjct: 53 VVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV-----ESAQQPKQVLKMEVAVLKK 107 Query: 241 VNSR-FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 + + V + +V+ L G +L + F + + +I + Sbjct: 108 LQGKDHVCRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESI 166 Query: 300 EDLHRERIVYRDLKPENI----LLDDHGHIRISDLGLAVHVPEG-------QTIKGRVGT 348 E +H ++RD+KP N L + + D GLA + + G GT Sbjct: 167 EAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGT 226 Query: 349 VGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVER------LVK 402 V Y + KN D W+L +L E GQ P+++ K K + ++ L+K Sbjct: 227 VRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLK 286 Query: 403 EVPEEY 408 +P E+ Sbjct: 287 HMPSEF 292 >4NFN-A nrPDB Length = 309 Score = 157 bits (397), Expect = 1e-38, Method: Composition-based stats. Identities = 54/246 (21%), Positives = 98/246 (39%), Gaps = 24/246 (9%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 V K+ ++ + +G GGFGE+ T + A K ++ + + E +L+K Sbjct: 18 VVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV-----ESAQQPKQVLKMEVAVLKK 72 Query: 241 VNSR-FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299 + + V + +V+ L G +L + F + + +I + Sbjct: 73 LQGKDHVCRFIGCGRNEKFNYVVMQL-QGRNLADLRRSQPRGTFTLSTTLRLGKQILESI 131 Query: 300 EDLHRERIVYRDLKPENI----LLDDHGHIRISDLGLAVHVPEG-------QTIKGRVGT 348 E +H ++RD+KP N L + + D GLA + + G GT Sbjct: 132 EAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGT 191 Query: 349 VGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVER------LVK 402 V Y + KN D W+L +L E GQ P+++ K K + ++ L+K Sbjct: 192 VRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLK 251 Query: 403 EVPEEY 408 +P E+ Sbjct: 252 HMPSEF 257 >4F9B-A nrPDB Length = 361 Score = 157 bits (396), Expect = 2e-38, Method: Composition-based stats. Identities = 65/365 (17%), Positives = 110/365 (30%), Gaps = 101/365 (27%) Query: 174 KWLERQPVTKNTFRQYRVLGKGGFGEVCACQV---RATGKMYACKKLEKKRIKKRKGEAM 230 K E P N F+ +G+G F V + A K L Sbjct: 11 KLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHL-----IPTSHPIR 65 Query: 231 ALNEKQILEKVN-SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAV 289 E Q L V+ + Y + D + + + + + Sbjct: 66 IAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDIL-----NSLSFQEVR 120 Query: 290 FYAAEICCGLEDLHRERIVYRDLKPENILLDDH-GHIRISDLGLA--------------- 333 Y + L+ +H+ IV+RD+KP N L + + D GLA Sbjct: 121 EYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQ 180 Query: 334 --------------VHVPEGQTIKGRVGTVGYMAPEVVKNER-YTFSPDWWALGCLLYEM 378 + + Q + R GT G+ APEV+ T + D W+ G + + Sbjct: 181 SEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSL 240 Query: 379 IAGQSPFQQRKK------KIKREEVERLVKEVPEEYSERF-------SPQARSLCSQL-- 423 ++G+ PF + +I R + + + + + R LC +L Sbjct: 241 LSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRG 300 Query: 424 -------LC-----------------------------KDPAERLGCRGGSAREVKEHPL 447 L +PA R+ +A E HP Sbjct: 301 MDSSTPKLTSDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRI-----TAEEALLHPF 355 Query: 448 FKKLN 452 FK ++ Sbjct: 356 FKDMS 360 >3SOC-A nrPDB Length = 322 Score = 155 bits (393), Expect = 4e-38, Method: Composition-based stats. Identities = 60/315 (19%), Positives = 108/315 (34%), Gaps = 64/315 (20%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI 222 +++YF + V +G FG V Q+ + A K + Sbjct: 17 ENLYFQSM--------------PLQLLEVKARGRFGCVWKAQLL--NEYVAVKIFPIQDK 60 Query: 223 KKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKD----ALCLVLTLMNGGDLKFHIYHM 278 + + E E L + ++ A + L L+ G L + Sbjct: 61 QSWQNEY----EVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKAN 116 Query: 279 GQAGFPEARAVFYAAEICCGLEDLHR----------ERIVYRDLKPENILLDDHGHIRIS 328 A + GL LH I +RD+K +N+LL ++ I+ Sbjct: 117 ---VVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIA 173 Query: 329 DLGLAVHVPEGQT---IKGRVGTVGYMAPEVVKN-----ERYTFSPDWWALGCLLYEMIA 380 D GLA+ G++ G+VGT YMAPEV++ D +A+G +L+E+ + Sbjct: 174 DFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELAS 233 Query: 381 GQ-----------SPFQQRK------KKIKREEVERLVKEVPEEYSERFSPQA--RSLCS 421 PF++ + ++ V + + V +Y ++ + A Sbjct: 234 RCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIE 293 Query: 422 QLLCKDPAERLGCRG 436 + D RL Sbjct: 294 ECWDHDAEARLSAGC 308 >5FQD-C nrPDB Length = 341 Score = 153 bits (388), Expect = 2e-37, Method: Composition-based stats. Identities = 46/238 (19%), Positives = 93/238 (39%), Gaps = 25/238 (10%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 + ++ R +G G FG++ G+ A K ++ L E ++ + Sbjct: 16 IVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVK-----LESQKARHPQLLYESKLYKI 70 Query: 241 VNS----RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 + + + KD LV+ L+ G L+ +++ F + A ++ Sbjct: 71 LQGGVGIPHI-RWYG--QEKDYNVLVMDLL-GPSLED-LFNFCSRRFTMKTVLMLADQMI 125 Query: 297 CGLEDLHRERIVYRDLKPENILLDDHGHIR---ISDLGLAVHVPEGQTI--------KGR 345 +E +H + ++RD+KP+N L+ H + D GLA + +T K Sbjct: 126 SRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNL 185 Query: 346 VGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKE 403 GT Y + + D +LG +L P+Q K K+++ E++ ++ Sbjct: 186 TGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEK 243 >5M07-A nrPDB Length = 276 Score = 153 bits (387), Expect = 2e-37, Method: Composition-based stats. Identities = 51/270 (18%), Positives = 89/270 (32%), Gaps = 30/270 (11%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 VT + R+LG GEV Q A K L + E ++ + Sbjct: 27 VTFAGYTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAAR 86 Query: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 + ++ + E L + + ++G D H+ A P + + L+ Sbjct: 87 LFHPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALD 146 Query: 301 DLHRERIVYRDLKPENILLDD----HGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV 356 H+ +++RD+ P N++L I ++D G+A Y APE+ Sbjct: 147 YAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-------------PSYPAPEL 193 Query: 357 VKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQA 416 D +AL + AG P + + P + S A Sbjct: 194 SAGADVDGRADQYALALTAIHLFAGAPPVDRSHTGPLQ----------PPKLSAFRPDLA 243 Query: 417 R--SLCSQLLCKDPAERLGCRGGSAREVKE 444 R + S+ L PA+R G + Sbjct: 244 RLDGVLSRALATAPADRFG-SCREFADAMN 272 >5E8V-A nrPDB Length = 316 Score = 153 bits (387), Expect = 2e-37, Method: Composition-based stats. Identities = 56/292 (19%), Positives = 103/292 (35%), Gaps = 53/292 (18%) Query: 191 VLGKGGFGEVCACQVRATG----KMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFV 246 ++GKG F EV +++ + A K + K E ++ + + Sbjct: 16 LVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDIN----LKHENI 71 Query: 247 VSLAYAYETKDAL----CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 + A E K L L+ G+L+ ++ + + + G+ L Sbjct: 72 LQFLTAEERKTELGKQYWLITAFHAKGNLQEYL---TRHVISWEDLRKLGSSLARGIAHL 128 Query: 303 HR---------ERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI-----KGRVGT 348 H IV+RDLK NIL+ + + D GL++ + ++ G+VGT Sbjct: 129 HSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGT 188 Query: 349 VGYMAPEV------VKNERYTFSPDWWALGCLLYEMIAG----------QSPFQQR---- 388 YMAPEV ++N D +++ +L+EM + + PF + Sbjct: 189 ARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREH 248 Query: 389 ---KKKIKREEVERLVKEVPEEYSERFSPQ-ARSLCSQLLCKDPAERLGCRG 436 + E+P + Q ++ DP RL + Sbjct: 249 PCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQC 300 >3G2F-A nrPDB Length = 336 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 60/308 (19%), Positives = 101/308 (32%), Gaps = 55/308 (17%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + + ++G+G +G V + + A K + E ++E N Sbjct: 13 DNLKLLELIGRGRYGAVYKGSLDE--RPVAVKVFSFANRQNFINEKNIYR-VPLMEHDNI 69 Query: 244 -RFVVSLAYAYETKD-ALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLED 301 RF+V LV+ G L ++ + A + GL Sbjct: 70 ARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTS---DWVSSCRLAHSVTRGLAY 126 Query: 302 LH---------RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIK--------- 343 LH + I +RDL N+L+ + G ISD GL++ + + ++ Sbjct: 127 LHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAI 186 Query: 344 GRVGTVGYMAPEVVKN-------ERYTFSPDWWALGCLLYEMIAGQS-PFQQRKKKIKRE 395 VGT+ YMAPEV++ E D +ALG + +E+ + F + Sbjct: 187 SEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQM 246 Query: 396 EVERLVKEVP------------------EEYSERFSPQARSL---CSQLLCKDPAERLGC 434 + V P E + S RSL +D RL Sbjct: 247 AFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTA 306 Query: 435 RGGSAREV 442 + R Sbjct: 307 QCAEERMA 314 >5X18-A nrPDB Length = 295 Score = 152 bits (385), Expect = 3e-37, Method: Composition-based stats. Identities = 53/231 (22%), Positives = 93/231 (40%), Gaps = 23/231 (9%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALN-EKQILEKVNS 243 ++ + +G+G FG + G A K + RK EA L E + + +N Sbjct: 8 HYKIGKKIGEGSFGVLFEGTNMINGVPVAIK------FEPRKTEAPQLRDEYKTYKILNG 61 Query: 244 -RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDL 302 + Y + LV+ L+ G L+ ++ F V A ++ +EDL Sbjct: 62 TPNIPYAYYFGQEGLHNILVIDLL-GPSLED-LFDWCGRKFSVKTVVQVAVQMITLIEDL 119 Query: 303 HRERIVYRDLKPENILLDDHGH-----IRISDLGLAVHVPE--------GQTIKGRVGTV 349 H ++YRD+KP+N L+ G I + D G+A + + K GT Sbjct: 120 HAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTA 179 Query: 350 GYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERL 400 YM+ + D ALG + + + G P+Q K +++ E++ Sbjct: 180 RYMSINTHLGREQSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKI 230 >2CHL-A nrPDB Length = 351 Score = 152 bits (383), Expect = 5e-37, Method: Composition-based stats. Identities = 54/252 (21%), Positives = 101/252 (40%), Gaps = 28/252 (11%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRI 222 +++YF + FR + +G G FGE+ + T + A K + + Sbjct: 16 ENLYFQSM-------GVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIK---LEPM 65 Query: 223 KKRKGEAMALNEKQILEKVNS-RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQA 281 K R + E + +++ S + + Y +VL L+ G L+ ++ + Sbjct: 66 KSRAPQLHL--EYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELL-GPSLED-LFDLCDR 121 Query: 282 GFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGH-----IRISDLGLAVHV 336 F + A ++ +E +H + ++YRD+KPEN L+ G+ I I D LA Sbjct: 122 TFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEY 181 Query: 337 PE--------GQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQR 388 + + K GT YM+ + + D ALG + + G P+Q Sbjct: 182 IDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGL 241 Query: 389 KKKIKREEVERL 400 K +E +++ Sbjct: 242 KADTLKERYQKI 253 >2CMW-A nrPDB Length = 310 Score = 150 bits (380), Expect = 1e-36, Method: Composition-based stats. Identities = 53/229 (23%), Positives = 95/229 (41%), Gaps = 22/229 (9%) Query: 187 RQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS--R 244 R + +G G FGE+ + T + A K + IK R + E + +++ S Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIK---LEPIKSRAPQLHL--EYRFYKQLGSAGE 57 Query: 245 FVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 + + Y +VL L+ G L+ ++ + F + A ++ +E +H Sbjct: 58 GLPQVYYFGPCGKYNAMVLELL-GPSLED-LFDLCDRTFTLKTVLMIAIQLLSRMEYVHS 115 Query: 305 ERIVYRDLKPENILLDDHGH-----IRISDLGLAVHVPE--------GQTIKGRVGTVGY 351 + ++YRD+KPEN L+ G+ I I D GLA + + K GT Y Sbjct: 116 KNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY 175 Query: 352 MAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERL 400 M+ + + D ALG + + G P+Q K +E +++ Sbjct: 176 MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKI 224 >4I94-A nrPDB Length = 300 Score = 149 bits (377), Expect = 3e-36, Method: Composition-based stats. Identities = 46/236 (19%), Positives = 93/236 (39%), Gaps = 10/236 (4%) Query: 199 EVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDA 258 V ++ + A K+ + K L E + + ++ + + +L + Sbjct: 44 VVYKGKL-ENQRRIAVKRFNR---KSWPDSRQFLEEAKAVGQLRNHRMANLLGCCYEDEE 99 Query: 259 LCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRER-IVYRDLKPENI 317 L+ M L H++H A + A I LE + +Y DL + Sbjct: 100 RLLIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYRV 159 Query: 318 LLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYE 377 L DD + R+S GL + +G++ + + PE ++ R T ++ G LL + Sbjct: 160 LFDDDANPRLSCFGLMKNSRDGKSYSTN---LAFTPPEYLRTGRVTPESVIYSFGTLLLD 216 Query: 378 MIAGQS-PFQQRKKKIKREEVERLVKE-VPEEYSERFSPQARSLCSQLLCKDPAER 431 +++G+ P I+ ++ L+ + ++S + L S+ L +P ER Sbjct: 217 LLSGKHIPPSHALDLIRDRNIQMLMDSGLEGQFSSDDGTELIRLASRCLQYEPRER 272 >2C47-A nrPDB Length = 313 Score = 148 bits (373), Expect = 7e-36, Method: Composition-based stats. Identities = 54/230 (23%), Positives = 96/230 (41%), Gaps = 21/230 (9%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN-S 243 FR + +G G FGE+ + T + A K + IK R + E + ++++ + Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK---LEPIKSRAPQLHL--EYRFYKQLSAT 59 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 V + Y +VL L+ G L+ ++ + F + A ++ +E +H Sbjct: 60 EGVPQVYYFGPCGKYNAMVLELL-GPSLED-LFDLCDRTFTLKTVLMIAIQLITRMEYVH 117 Query: 304 RERIVYRDLKPENILLDDHGH-----IRISDLGLAVHVPE--------GQTIKGRVGTVG 350 + ++YRD+KPEN L+ G I I D GLA + + K GT Sbjct: 118 TKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTAR 177 Query: 351 YMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERL 400 YM+ + + D ALG + + G P+Q K +E +++ Sbjct: 178 YMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKI 227 >3REP-A nrPDB Length = 271 Score = 148 bits (373), Expect = 8e-36, Method: Composition-based stats. Identities = 51/262 (19%), Positives = 101/262 (38%), Gaps = 24/262 (9%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 + L + GE+ + + + K+ +K + E L Sbjct: 7 IDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRD---FNEECPRLRI 63 Query: 241 VNSRFVVSLAYAYETKD--ALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 + V+ + A ++ L+ M G L ++ +++AV +A ++ G Sbjct: 64 FSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARG 123 Query: 299 LEDLHR-ERIVYRD-LKPENILLDDHGHIRI--SDLGLAVHVPEGQTIKGRVGTVGYMAP 354 + LH E ++ R L ++++D+ RI +D+ + P GR+ ++AP Sbjct: 124 MAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQSP------GRMYAPAWVAP 177 Query: 355 EVVKNERYTF---SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEV--ERLVKEVPEEYS 409 E ++ + S D W+ LL+E++ + PF +V E L +P S Sbjct: 178 EALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGIS 237 Query: 410 ERFSPQARSLCSQLLCKDPAER 431 S L + +DPA+R Sbjct: 238 PHVSK----LMKICMNEDPAKR 255 >4RT7-A nrPDB Length = 415 Score = 144 bits (363), Expect = 1e-34, Method: Composition-based stats. Identities = 46/225 (20%), Positives = 86/225 (38%), Gaps = 25/225 (11%) Query: 233 NEKQILEKVNSRFVVSLAY-AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFY 291 E QI +S + L ++ ++D + N L+ + + Sbjct: 198 REVQI--HPDSDQISGLHGNSFHSEDEI----EYENQKRLEE---EEDLNVLTFEDLLCF 248 Query: 292 AAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVG---T 348 A ++ G+E L + V+RDL N+L+ ++I D GLA + R Sbjct: 249 AYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLP 308 Query: 349 VGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEE 407 V +MAPE + YT D W+ G LL+E+ + G +P+ ++ + ++ + Sbjct: 309 VKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQP 368 Query: 408 YSERFSPQARSLCSQLLCKDPAER---------LGCRGGSAREVK 443 + + + + D +R LGC+ A E Sbjct: 369 FYA--TEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAM 411 Score = 104 bits (260), Expect = 1e-22, Method: Composition-based stats. Identities = 26/154 (16%), Positives = 61/154 (39%), Gaps = 12/154 (7%) Query: 134 EQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLG 193 + K F+ ++L ++ + +Y ++ F ++++ + + +VLG Sbjct: 19 QGHKYKKQFRYESQLQMVQVTGSSDNEY----FYVDFREYEYDLKWEFPRENLEFGKVLG 74 Query: 194 KGGFGEVCACQV---RATGK--MYACKKLEKKRIKKRKGEAMALNEKQILEKVN-SRFVV 247 G FG+V TG A K L++K + ++E +++ ++ +V Sbjct: 75 SGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSER--EALMSELKMMTQLGSHENIV 132 Query: 248 SLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQA 281 +L A + L+ GDL ++ + Sbjct: 133 NLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREK 166 >4XHH-A nrPDB Length = 403 Score = 143 bits (362), Expect = 2e-34, Method: Composition-based stats. Identities = 46/234 (19%), Positives = 96/234 (41%), Gaps = 19/234 (8%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 FR R +G G FG++ +G+ A +LE R + + + + K + V Sbjct: 5 VGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI-RLESIRSRHPQLDYESRVYKYLSGGV 63 Query: 242 NSRFVVSLAYAYETKDALC-LVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 F+ + + +V+ L+ G L+ +++ F + A ++ C ++ Sbjct: 64 GIPFI----RWFGREGEYNAMVIDLL-GPSLED-LFNYCHRKFSFKTVIMLALQMICRVQ 117 Query: 301 DLHRERIVYRDLKPENILLD---DHGHIRISDLGLAVHVPE--------GQTIKGRVGTV 349 +H ++RD+KP+N L+ + + D GL+ + + K GT Sbjct: 118 YIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTA 177 Query: 350 GYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKE 403 Y + + D +LG +L G P+Q K K+++ +R++++ Sbjct: 178 RYASVNTHLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEK 231 >4NT4-A nrPDB Length = 312 Score = 143 bits (360), Expect = 2e-34, Method: Composition-based stats. Identities = 49/236 (20%), Positives = 91/236 (38%), Gaps = 27/236 (11%) Query: 185 TFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSR 244 FR + +G G FGE+ + + A K + +K + + E + + + S Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIKM---EPMKSKAPQLHL--EYRFYKLLGSH 67 Query: 245 ------FVVSLAYAYETKDALC-LVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICC 297 + + + +VL L+ G L+ ++++ F + A ++ Sbjct: 68 ADNAPDGIPRIYHLGTCGGRYNAMVLELL-GLSLED-LFNICARKFSLKTVLMIAKQLLH 125 Query: 298 GLEDLHRERIVYRDLKPENILLDDHGH-----IRISDLGLAVHVPE--------GQTIKG 344 +E +H ++YRD+KPEN L+ I I D GLA + + K Sbjct: 126 RIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKS 185 Query: 345 RVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERL 400 GT YM+ + D ALG + + G P+Q K +E +++ Sbjct: 186 LTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKI 241 >3HNG-A nrPDB Length = 360 Score = 143 bits (360), Expect = 3e-34, Method: Composition-based stats. Identities = 39/157 (24%), Positives = 73/157 (46%), Gaps = 8/157 (5%) Query: 280 QAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEG 339 + + Y+ ++ G+E L + ++RDL NILL ++ ++I D GLA + + Sbjct: 193 KEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKN 252 Query: 340 QTIKGRVGTV---GYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKR- 394 + T +MAPE + ++ Y+ D W+ G LL+E+ + G SP+ + Sbjct: 253 PDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFC 312 Query: 395 EEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 + ++ EYS +P+ + +DP ER Sbjct: 313 SRLREGMRMRAPEYS---TPEIYQIMLDCWHRDPKER 346 Score = 82.3 bits (202), Expect = 5e-16, Method: Composition-based stats. Identities = 22/122 (18%), Positives = 43/122 (35%), Gaps = 9/122 (7%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCAC-----QVRATGKMYACKKLEKKRIKKRKGEAMAL 232 + + + + LG+G FG+V + T + A K L++ + Sbjct: 21 KWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEY--KALM 78 Query: 233 NEKQILEKVNSR-FVVSLAYAYE-TKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVF 290 E +IL + VV+L A L +++ G+L ++ F A Sbjct: 79 TELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAAL 138 Query: 291 YA 292 + Sbjct: 139 HM 140 >5J0A-A nrPDB Length = 300 Score = 143 bits (360), Expect = 3e-34, Method: Composition-based stats. Identities = 63/291 (21%), Positives = 109/291 (37%), Gaps = 42/291 (14%) Query: 188 QYRVLGKGGFGE-VCACQVRATGKMY---ACKKLEK--KRIKKRKGEAMALNEKQILEKV 241 + LG G G V + G + A KK+ + + ++E +IL+ + Sbjct: 13 FMQKLGFGT-GVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSL 71 Query: 242 NSRFVVSLAYAYETKD-ALCLVLTLMNGG-----DLKFHIYHMGQAGFPEARAVFYAAEI 295 + +V E D +LCL + GG DL Y Q FP A + A + Sbjct: 72 HHPNIVGYRAFTEANDGSLCLAMEY--GGEKSLNDLIEERYKASQDPFPAAIILKVALNM 129 Query: 296 CCGLEDLHR-ERIVYRDLKPENILLDDHG-HIRISDLGLAVHVPEGQTIKG----RVGTV 349 GL+ LH+ +++++ D+K N+++ I+I D+G+++ + E + +GT Sbjct: 130 ARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTE 189 Query: 350 GYMAPEVVKNERY-TFSPDWWALGCLLYEMIAGQSPFQQRKKKIKR------------EE 396 + E V+ T D +A G L+EM+ P E Sbjct: 190 PWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEA 249 Query: 397 VERLVKEVPEEYSERFSP---QARSLCSQLLCKDPAERLGCRGGSAREVKE 444 + P E + L S +DP +R SA + E Sbjct: 250 YYAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDR-----PSAAHIVE 295 >3VHK-A nrPDB Length = 368 Score = 142 bits (358), Expect = 4e-34, Method: Composition-based stats. Identities = 44/168 (26%), Positives = 76/168 (45%), Gaps = 13/168 (7%) Query: 283 FPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHV---PEG 339 + Y+ ++ G+E L + ++RDL NILL + ++I D GLA + P+ Sbjct: 197 LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDY 256 Query: 340 QTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVE 398 + +MAPE + + YT D W+ G LL+E+ + G SP+ K EE Sbjct: 257 VRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVK---IDEEFC 313 Query: 399 RLVKEVPEEYSERF-SPQARSLCSQLLCKDPAERLGCRGGSAREVKEH 445 R +KE + + +P+ +P++R + E+ EH Sbjct: 314 RRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQR-----PTFSELVEH 356 Score = 84.7 bits (208), Expect = 1e-16, Method: Composition-based stats. Identities = 26/143 (18%), Positives = 52/143 (36%), Gaps = 15/143 (10%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCAC----QVR-ATGKMYACKKLEKKRIKKRKGEAMAL 232 + ++ + + LG+G FG+V + AT + A K L++ + Sbjct: 23 KWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSE--HRALM 80 Query: 233 NEKQILEKVNSR-FVVSLAYAYETK-DALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVF 290 +E +IL + VV+L A L +++ G+L ++ P Sbjct: 81 SELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGA 140 Query: 291 YAAEICCGLEDLHRERIVYRDLK 313 + G + + + DLK Sbjct: 141 RFRQ---GKDYV---GAIPVDLK 157 >4XHL-A nrPDB Length = 394 Score = 142 bits (357), Expect = 5e-34, Method: Composition-based stats. Identities = 49/254 (19%), Positives = 103/254 (40%), Gaps = 26/254 (10%) Query: 182 TKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV 241 FR R +G G FG++ +G+ A +LE R + + + + + + V Sbjct: 5 VGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAI-RLESIRSRHPQLDYESRVYRYLSGGV 63 Query: 242 NSRFVVSLAYAYETKDALC-LVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 F+ + + +V+ L+ G L+ +++ F + A ++ C ++ Sbjct: 64 GIPFI----RWFGREGEYNAMVIDLL-GPSLED-LFNYCHRRFSFKTVIMLALQMFCRIQ 117 Query: 301 DLHRERIVYRDLKPENILLD---DHGHIRISDLGLAVHVPE--------GQTIKGRVGTV 349 +H ++RD+KP+N L+ + + D GL+ + + K GT Sbjct: 118 YIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTA 177 Query: 350 GYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYS 409 Y + + D +LG +L G P+Q K K+++ +R+++ Sbjct: 178 RYASVNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIME------- 230 Query: 410 ERFSPQARSLCSQL 423 ++ + +LCS L Sbjct: 231 KKLNVSVETLCSGL 244 >2QLU-A nrPDB Length = 314 Score = 141 bits (355), Expect = 9e-34, Method: Composition-based stats. Identities = 58/300 (19%), Positives = 103/300 (34%), Gaps = 55/300 (18%) Query: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 V + + + + +G FG V Q+ A K + + + E E Sbjct: 12 VPRGSLQLLEIKARGRFGCVWKAQLMND--FVAVKIFPLQDKQSWQSE----REIFSTPG 65 Query: 241 VNSRFVVSLAYAYETKD----ALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 + ++ A + L L+ + G L ++ A + Sbjct: 66 MKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLK---GNIITWNELCHVAETMS 122 Query: 297 CGLEDLHR-----------ERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT---I 342 GL LH I +RD K +N+LL ++D GLAV G+ Sbjct: 123 RGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDT 182 Query: 343 KGRVGTVGYMAPEVVKN-----ERYTFSPDWWALGCLLYEMIAGQ-----------SPFQ 386 G+VGT YMAPEV++ D +A+G +L+E+++ PF+ Sbjct: 183 HGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFE 242 Query: 387 ----QRKKKIKREEV---ERLVKEVPEEYSERFSPQARSL---CSQLLCKDPAERLGCRG 436 Q + +EV +++ + + + + P L + D RL Sbjct: 243 EEIGQHPSLEELQEVVVHKKMRPTIKDHWLKH--PGLAQLCVTIEECWDHDAEARLSAGC 300 >1CSN-A nrPDB Length = 298 Score = 140 bits (353), Expect = 2e-33, Method: Composition-based stats. Identities = 46/237 (19%), Positives = 91/237 (38%), Gaps = 21/237 (8%) Query: 178 RQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQI 237 + V ++ R +G+G FG + + A K +R +E + Sbjct: 4 QNNVVGVHYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKF-----EPRRSDAPQLRDEYRT 58 Query: 238 LEKV-NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEIC 296 + + + ++ Y + LV+ L+ G L+ + G+ F A ++ Sbjct: 59 YKLLAGCTGIPNVYYFGQEGLHNVLVIDLL-GPSLEDLLDLCGRK-FSVKTVAMAAKQML 116 Query: 297 CGLEDLHRERIVYRDLKPENILL-----DDHGHIRISDLGLAVHVPE--------GQTIK 343 ++ +H + +VYRD+KP+N L+ + I + D G+ + + K Sbjct: 117 ARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKK 176 Query: 344 GRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERL 400 GT YM+ + D ALG + + G P+Q K +++ ER+ Sbjct: 177 NLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERI 233 >2PZI-A nrPDB Length = 681 Score = 139 bits (350), Expect = 3e-33, Method: Composition-based stats. Identities = 63/266 (23%), Positives = 100/266 (37%), Gaps = 35/266 (13%) Query: 185 TFRQYRVLGKGGFGEVCACQVRA-TGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + + GG G + R G+ K L + + AMA Q L +V Sbjct: 81 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER--QFLAEVVH 138 Query: 244 RFVVSLAYAYETKDAL-----CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 +V + E D +V+ + G L P A A+ Y EI Sbjct: 139 PSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSL----KRSKGQKLPVAEAIAYLLEILPA 194 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVK 358 L LH +VY DLKPENI+L + +++ DLG + + GT G+ APE+V+ Sbjct: 195 LSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRI---NSFGYLYGTPGFQAPEIVR 250 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYS--ERFSPQA 416 T + D + +G L + R V +PE+ + + Sbjct: 251 TGP-TVATDIYTVGRTLAAL-----------TLDLPTRNGRYVDGLPEDDPVLKTYDSYG 298 Query: 417 RSLCSQLLCKDPAERLGCRGGSAREV 442 R L + + DP +R +A E+ Sbjct: 299 R-LLRRAIDPDPRQRFT----TAEEM 319 >4Y12-A nrPDB Length = 375 Score = 138 bits (349), Expect = 4e-33, Method: Composition-based stats. Identities = 63/266 (23%), Positives = 100/266 (37%), Gaps = 35/266 (13%) Query: 185 TFRQYRVLGKGGFGEVCACQVRA-TGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 + + GG G + R G+ K L + + AMA Q L +V Sbjct: 120 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAER--QFLAEVVH 177 Query: 244 RFVVSLAYAYETKDAL-----CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCG 298 +V + E D +V+ + G L P A A+ Y EI Sbjct: 178 PSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSL----KRSKGQKLPVAEAIAYLLEILPA 233 Query: 299 LEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVK 358 L LH +VY DLKPENI+L + +++ DLG + + GT G+ APE+V+ Sbjct: 234 LSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRI---NSFGYLYGTPGFQAPEIVR 289 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYS--ERFSPQA 416 T + D + +G L + R V +PE+ + + Sbjct: 290 TGP-TVATDIYTVGRTLAAL-----------TLDLPTRNGRYVDGLPEDDPVLKTYDSYG 337 Query: 417 RSLCSQLLCKDPAERLGCRGGSAREV 442 R L + + DP +R +A E+ Sbjct: 338 R-LLRRAIDPDPRQRFT----TAEEM 358 >5X1R-A nrPDB Length = 302 Score = 136 bits (342), Expect = 3e-32, Method: Composition-based stats. Identities = 50/283 (17%), Positives = 94/283 (33%), Gaps = 29/283 (10%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAM------------- 230 N F +G+GGFG V + A K+ + KR + Sbjct: 21 NEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQ 80 Query: 231 -----ALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPE 285 + E ++L + + ++ + +E + +G LK ++ E Sbjct: 81 AGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLK-NLQAQQPEKIDE 139 Query: 286 ARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAV-HVPEGQTIKG 344 A + + +H+E ++RD+ +NI + + + D G A + Sbjct: 140 AWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLSDETE 199 Query: 345 RVGTVGYMAPEVVKNERYTFS---PDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLV 401 V G+ E D +ALG +L+ +I G P +E Sbjct: 200 IVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP-----PVSVVRSIEDSY 254 Query: 402 KEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKE 444 + + E +SP+ + L P +R A E+ E Sbjct: 255 QPLTERRPAGYSPELLRTVDRALALKPEDRPQTIDEMA-ELLE 296 >4MWI-A nrPDB Length = 294 Score = 134 bits (338), Expect = 9e-32, Method: Composition-based stats. Identities = 42/258 (16%), Positives = 93/258 (36%), Gaps = 25/258 (9%) Query: 201 CACQVRATGKMYACKKLEKKRIKKRKGEAMALN-EKQILEKVNSRFVVSLAYAYETKD-- 257 + A K +K + N E + ++K S ++ + + Sbjct: 41 YKGEYHRA--PVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVT 98 Query: 258 --ALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH--RERIVYRDLK 313 +V+ G L+ + + + A GL LH ++ ++ Sbjct: 99 PPQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGA--ARGLYRLHHSEAPELHGKIR 156 Query: 314 PENILLDDHGHIRISDLGL-----AVHVPEGQTIKGRVGTVGYMAPEVVKN--ERYTFSP 366 N L+ ++++ L ++ + + RV + Y++P+ +++ +Y Sbjct: 157 SSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKS 216 Query: 367 DWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCK 426 + ++ G +L+E+ G PFQ + R+ V VK E E + R + + Sbjct: 217 EIYSFGIVLWEIATGDIPFQGCNSEKIRKLVA--VKRQQEPLGEDCPSELREIIDECRAH 274 Query: 427 DPAERLGCRGGSAREVKE 444 DP+ R S E+ + Sbjct: 275 DPSVR-----PSVDEILK 287 >4M69-B nrPDB Length = 283 Score = 133 bits (335), Expect = 2e-31, Method: Composition-based stats. Identities = 39/263 (14%), Positives = 89/263 (33%), Gaps = 27/263 (10%) Query: 197 FGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALN-EKQILEKVNSRFVVSLAYAYET 255 + + + K + + N E + ++K +S ++ + Sbjct: 22 MSTIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICID 79 Query: 256 KD----ALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 + +V+ G L+ + GL LH ++R+ Sbjct: 80 QTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVR--SLLVLRAARGLYRLHHSETLHRN 137 Query: 312 LKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVG-------YMAPEVVKN--ERY 362 + + L+ ++++ L+ + + T Y++PE +KN Y Sbjct: 138 ISSSSFLVAGGYQVKLAGFELSK--TQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLY 195 Query: 363 TFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQ 422 + ++ G +L+E+ G+ PF+ K RE V K+ P + R + ++ Sbjct: 196 DIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEP--VGQDCPELLREIINE 253 Query: 423 LLCKDPAERLGCRGGSAREVKEH 445 +P++R S + E Sbjct: 254 CRAHEPSQR-----PSVDGILER 271 >4BTF-A nrPDB Length = 469 Score = 133 bits (334), Expect = 3e-31, Method: Composition-based stats. Identities = 39/263 (14%), Positives = 89/263 (33%), Gaps = 27/263 (10%) Query: 197 FGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALN-EKQILEKVNSRFVVSLAYAYET 255 + + + K + + N E + ++K +S ++ + Sbjct: 208 MSTIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICID 265 Query: 256 KD----ALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 311 + +V+ G L+ + GL LH ++R+ Sbjct: 266 QTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVR--SLLVLRAARGLYRLHHSETLHRN 323 Query: 312 LKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVG-------YMAPEVVKN--ERY 362 + + L+ ++++ L+ + + T Y++PE +KN Y Sbjct: 324 ISSSSFLVAGGYQVKLAGFELSK--TQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLY 381 Query: 363 TFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQ 422 + ++ G +L+E+ G+ PF+ K RE V K+ P + R + ++ Sbjct: 382 DIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEP--VGQDCPELLREIINE 439 Query: 423 LLCKDPAERLGCRGGSAREVKEH 445 +P++R S + E Sbjct: 440 CRAHEPSQR-----PSVDGILER 457 >5OAT-A nrPDB Length = 411 Score = 129 bits (325), Expect = 3e-30, Method: Composition-based stats. Identities = 61/319 (19%), Positives = 112/319 (35%), Gaps = 61/319 (19%) Query: 176 LERQPVTKNTFRQYRVLGKGGFGEVCACQVRAT-----GKMYACKKLEKKRIKKRKGEAM 230 E P+T N + + KG G V + +V+ +A K + I++ E + Sbjct: 3 FESNPITLNDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEIL 62 Query: 231 ALN-------------------EKQILEKVNS----RFVVSLAYAYETKDALCLVLTLMN 267 E ++ + +V++ + L L Sbjct: 63 KAMYRETVPARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHP 122 Query: 268 GGD-------LKFHIYHMGQAGF-----PEARAVFYAAEICCGLEDLHRERIVYRDLKPE 315 G+ L Y F ++ A++ G+ + I +RDLK + Sbjct: 123 EGEGRNMSLFLLMKRYDCNLQSFLSTAPSTRTSLLLLAQLLEGVAHMTAHGIAHRDLKSD 182 Query: 316 NILLD----DHGHIRISDLGLA-------VHVPEGQTIKGRVGTVGYMAPEVVKNERYTF 364 N+LLD + + ISD G + +P + G MAPE++ + TF Sbjct: 183 NLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTF 242 Query: 365 ------SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARS 418 D WA+G + YE+ +PF + E + ++P+E ++ Sbjct: 243 SVLNYSKADLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKEGDLPKLPDEVPTVI----QA 298 Query: 419 LCSQLLCKDPAERLGCRGG 437 L + LL ++P +RL Sbjct: 299 LVANLLKRNPNKRLDPEVA 317 >5USZ-A nrPDB Length = 289 Score = 128 bits (322), Expect = 6e-30, Method: Composition-based stats. Identities = 44/269 (16%), Positives = 96/269 (35%), Gaps = 29/269 (10%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGK-------MYACKKLEKKRIKKRKGEAMAL 232 + LG+G F ++ R G K L+K R Sbjct: 4 KIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKA---HRNYSESFF 60 Query: 233 NEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYA 292 ++ K++ + +V D LV + G L ++ + A Sbjct: 61 EAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNC-INILWKLEVA 119 Query: 293 AEICCGLEDLHRERIVYRDLKPENILL--------DDHGHIRISDLGLAVHVPEGQTIKG 344 ++ + L +++ ++ +NILL + I++SD G+++ V ++ Sbjct: 120 KQLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQE 179 Query: 345 RVGTVGYMAPEVVKN-ERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVK 402 R + ++ PE ++N + + D W+ G L+E+ + G P + K + E Sbjct: 180 R---IPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDR-- 234 Query: 403 EVPEEYSERFSPQARSLCSQLLCKDPAER 431 + + + +L + + +P R Sbjct: 235 ---HQLPAPKAAELANLINNCMDYEPDHR 260 >4L00-A nrPDB Length = 304 Score = 127 bits (320), Expect = 1e-29, Method: Composition-based stats. Identities = 54/299 (18%), Positives = 109/299 (36%), Gaps = 41/299 (13%) Query: 179 QPVTKNTFRQYRVLGKGGFGEVCACQ------VRATGKMYACKKLEKKRIKKRKGEAMAL 232 + K Q LG+G + + T + K + K + ++A Sbjct: 20 DRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAF 79 Query: 233 NEK-QILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFY 291 E ++ +V+ + +V L +V + GG L + H Sbjct: 80 FEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFM-HRKSDVLTTPWKFKV 138 Query: 292 AAEICCGLEDLHRERIVYRDLKPENILLDDHGH-------IRISDLGLAVHVPEGQTIKG 344 A ++ L L + +V+ ++ +N+LL G I++SD G+ + V Q Sbjct: 139 AKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIE 198 Query: 345 RVGTVGYMAPEVVKNER-YTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVK 402 R + ++APE V++ + + + D W+ G L+E+ G+ P + + K E + Sbjct: 199 R---IPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCR 255 Query: 403 EVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKL--NFKRLGAG 459 V + L ++ + DP +R P F+ + + +L Sbjct: 256 PVTPSC-----KELADLMTRCMNYDPNQR--------------PFFRAIMRDINKLEEQ 295 >6J6I-B nrPDB Length = 351 Score = 125 bits (314), Expect = 5e-29, Method: Composition-based stats. Identities = 52/272 (19%), Positives = 103/272 (37%), Gaps = 36/272 (13%) Query: 144 ELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCAC 203 + + E + + ++ S + ++ + +KW R + ++ R F E Sbjct: 44 PIRSFSPEQI-LKATNNFDSSCFVSQDVYYKWY-RGEIEDRSYMIKR------FSE---- 91 Query: 204 QVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVL 263 TGK + K++ + N + L LV Sbjct: 92 -DEITGKRHRVKEVYNDIVLSA-------------RMSNHSNFLQLLGCCLEFPFPVLVF 137 Query: 264 TLMNGGDLKFH---IYHMGQAGFPEARAVFYAAEICCGLEDLHR---ERIVYRDLKPENI 317 G + I + ++ P + + EI + LH + I++RD+KP ++ Sbjct: 138 EFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHV 197 Query: 318 LLDDHGHIRISDLGLAVHVPEGQT---IKGRVGTVGYMAPEVVKNERYTFSPDWWALGCL 374 LD + ++SDL ++ +PEG++ + +GT GY+ P K T D ++ G Sbjct: 198 FLDKNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDPLYHKTCFVTEYTDVYSFGIC 257 Query: 375 LYEMIAGQSPFQQRKKKIKREEVERLVKEVPE 406 L +I G+ + + LV+E+ E Sbjct: 258 LLVIITGKPAIMTISDGD-LQGILSLVRELCE 288 >4L68-A nrPDB Length = 340 Score = 122 bits (306), Expect = 5e-28, Method: Composition-based stats. Identities = 45/206 (21%), Positives = 74/206 (35%), Gaps = 14/206 (6%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 N F ++ G + G A K L ++ GE E L ++ Sbjct: 40 NNFNSENIIVSTRTGTTYKA-LLPDGSALAVKHLSTCKL----GEREFRYEMNQLWELRH 94 Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 + L ++ LV M+ G L + + + GL LH Sbjct: 95 SNLAPLLGFCVVEEEKFLVYKYMSNGTLHSLL-DSNRGELDWSTRFRIGLGAARGLAWLH 153 Query: 304 ---RERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT-----IKGRVGTVGYMAPE 355 R I+++++ IL+D+ RI D GLA + + G +G GY+APE Sbjct: 154 HGCRPPILHQNICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPE 213 Query: 356 VVKNERYTFSPDWWALGCLLYEMIAG 381 + D + LG +L E+ G Sbjct: 214 YSTTMLASLKGDVYGLGVVLLELATG 239 >4JRN-A nrPDB Length = 372 Score = 121 bits (303), Expect = 9e-28, Method: Composition-based stats. Identities = 55/297 (18%), Positives = 98/297 (32%), Gaps = 55/297 (18%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN--------- 242 LG GGF V T + A K ++ + E + Sbjct: 76 LGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDAQ 135 Query: 243 --SRF-----VVSLAYAYETKD-----------ALCLVLTLMNGGDLKFHIY------HM 278 RF VV L + + L++ D+ I + Sbjct: 136 ESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEA-DMSKVISWVFGDASV 194 Query: 279 GQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPE 338 ++ F ++ +++ + ++ + IV+ D+KP N LL G + + D G Sbjct: 195 NKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFG---TYRI 251 Query: 339 GQTIKGRVGTVGYMAPE---VVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKRE 395 ++ +GT GY PE YTF D W LG LY + + P + Sbjct: 252 NNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERP-------TPAD 304 Query: 396 EVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 + + + + L LL +DP +R+ + E FK+++ Sbjct: 305 GIWDYLHFADCPSTPEL---VQDLIRSLLNRDPQKRMLPL-----QALETAAFKEMD 353 >4WOV-A nrPDB Length = 317 Score = 115 bits (287), Expect = 7e-26, Method: Composition-based stats. Identities = 54/303 (17%), Positives = 100/303 (33%), Gaps = 46/303 (15%) Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATG------------- 209 +++ F + L V + Q LG+G V ++R G Sbjct: 14 ETVRFQGHMNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDED 73 Query: 210 -----------KMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDA 258 K L+ ++ +V+ + + Sbjct: 74 PLVPGRDRGQELRVVLKVLDPS---HHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPE 130 Query: 259 LCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENIL 318 +V + G L + + P A + A ++ L L + +V+ ++ NIL Sbjct: 131 NIMVTEYVEHGPLDVWLR-RERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNIL 189 Query: 319 L-------DDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE--RYTFSPDWW 369 L I++SD G+ + + RV + ++APE + + + D W Sbjct: 190 LARLGLAEGTSPFIKLSDPGVGLGALSREE---RVERIPWLAPECLPGGANSLSTAMDKW 246 Query: 370 ALGCLLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDP 428 G L E+ G++P Q R K +R + PQ +L SQ L +P Sbjct: 247 GFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSC-----PQLATLTSQCLTYEP 301 Query: 429 AER 431 +R Sbjct: 302 TQR 304 Score = 32.7 bits (73), Expect = 0.51, Method: Composition-based stats. Identities = 16/65 (24%), Positives = 25/65 (38%), Gaps = 8/65 (12%) Query: 91 EVTPDDKRKACGRQLTQN--FLSHTGPDLIPEVPRQLVTNCTQRLEQGPC-----KDLFQ 143 E+ D + R ++ F P P QL T +Q L P + + + Sbjct: 254 EICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCP-QLATLTSQCLTYEPTQRPSFRTILR 312 Query: 144 ELTRL 148 +LTRL Sbjct: 313 DLTRL 317 >6EQI-C nrPDB Length = 433 Score = 113 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 52/326 (15%), Positives = 101/326 (30%), Gaps = 79/326 (24%) Query: 184 NTFRQYRVLGKGGFGEVCACQVRATG-----KMYACKKLEKKRIKKRKGEAM--ALNE-- 234 + + KG V + +++ A K + ++ + E Sbjct: 15 DELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRETV 74 Query: 235 -------------KQILEKVN-----SRFVVSLAYAYETKDA------------------ 258 + + +V + + + Sbjct: 75 PAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRIN 134 Query: 259 ---------LCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVY 309 L LV+ + LK ++ + E + ++ I + Sbjct: 135 PEGSGRNMSLFLVMKRYDC-TLKEYLRDKTPNMRSSILLLSQLLE---AVAHMNIHNISH 190 Query: 310 RDLKPENILL-----DDHGHIRISDLGLAVH-------VPEGQTIKGRVGTVGYMAPEVV 357 RDLK +NIL+ D + I I+D G + +P + + G MAPE+ Sbjct: 191 RDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEIA 250 Query: 358 KNERYTF------SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSER 411 + TF D WA+G + YE+ +PF + K+ + + +E E + Sbjct: 251 NAKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDKTMKLLSKSYK---EEDLPELPDT 307 Query: 412 FSPQARSLCSQLLCKDPAERLGCRGG 437 R+L S +L + +RL C Sbjct: 308 IPFIIRNLVSNMLSRSTNKRLDCDVA 333 >5C01-A nrPDB Length = 342 Score = 113 bits (282), Expect = 3e-25, Method: Composition-based stats. Identities = 45/239 (18%), Positives = 84/239 (35%), Gaps = 22/239 (9%) Query: 203 CQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLV 262 + R K L+ ++ +V+ + + +V Sbjct: 101 GRDRGQELRVVLKVLDPS---HHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMV 157 Query: 263 LTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILL--- 319 + G L + + P A + A ++ L L + +V+ ++ NILL Sbjct: 158 TEYVEHGPLDVWLR-RERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARL 216 Query: 320 ----DDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE--RYTFSPDWWALGC 373 I++SD G+ + + RV + ++APE + + + D W G Sbjct: 217 GLAEGTSPFIKLSDPGVGLGALSREE---RVERIPWLAPECLPGGANSLSTAMDKWGFGA 273 Query: 374 LLYEMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 L E+ G++P Q R K +R + PQ +L SQ L +P +R Sbjct: 274 TLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSC-----PQLATLTSQCLTYEPTQR 327 Score = 33.8 bits (76), Expect = 0.22, Method: Composition-based stats. Identities = 16/67 (23%), Positives = 25/67 (37%), Gaps = 8/67 (11%) Query: 91 EVTPDDKRKACGRQLTQN--FLSHTGPDLIPEVPRQLVTNCTQRLEQGPC-----KDLFQ 143 E+ D + R ++ F P P QL T +Q L P + + + Sbjct: 277 EICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCP-QLATLTSQCLTYEPTQRPSFRTILR 335 Query: 144 ELTRLTH 150 +LTRL Sbjct: 336 DLTRLQP 342 >5UV4-A nrPDB Length = 311 Score = 107 bits (268), Expect = 1e-23, Method: Composition-based stats. Identities = 39/204 (19%), Positives = 80/204 (39%), Gaps = 15/204 (7%) Query: 190 RVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL 249 ++G+ G + G M K L++ K +K + E + L V +V L Sbjct: 31 EIIGRSCHGTSYKATL-DNGYMLTVKWLKEGFAKSKKEFS---REIKKLGSVRHPNLVPL 86 Query: 250 AYAY--ETKDALCLVLTLMNGGDLKFHIYHMGQAGFPE---ARAVFYAAEICCGLEDLHR 304 Y + ++ + L ++ + P + + A +I L+ LH Sbjct: 87 RGYYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHN 146 Query: 305 ERIV-YRDLKPENILL-DDHGHIRISDLGLAVHVPEGQTIKG--RVGTVGYMAPEVVKNE 360 ER++ + ++K N+L+ + ++D L + + G +GY PE Sbjct: 147 ERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSSTS 206 Query: 361 RY--TFSPDWWALGCLLYEMIAGQ 382 + + D +A G +L E++ G+ Sbjct: 207 KPCPSLKSDVYAFGVILLELLTGK 230 >6EWX-A nrPDB Length = 484 Score = 103 bits (258), Expect = 2e-22, Method: Composition-based stats. Identities = 53/237 (22%), Positives = 86/237 (36%), Gaps = 51/237 (21%) Query: 254 ETKDALCLVLTLMNGGDLKFHIY-----HMGQAGFPEARAVFYAAEICCGLEDLHRERIV 308 + +D + ++ + + H + E R F ++C GLE L I+ Sbjct: 173 QEQDCVVVITREVPHQTASDFVRDSVASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGII 232 Query: 309 YRDLKPENILL-----------------------------------------DDHGHIRI 327 +RDL EN+LL + I Sbjct: 233 HRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCPSAAPAATTACQGGPGEKHLPRLII 292 Query: 328 SDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQ 387 S+ A P G T + + +APE+V +Y D + G L+YE++ +PF+ Sbjct: 293 SNFLKAKQKPGGTTNLQQKKSQARLAPEIVSASQY-RKFDEFQTGILIYELLHQPNPFEV 351 Query: 388 RKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKE 444 R + RE R P +SP + L LL DP +R+ R G A+ V + Sbjct: 352 RAQ--LRERDYRREDLPPLPTLSLYSPGLQQLAHLLLEADPIKRI--RIGEAKRVLQ 404 >5CLR-A nrPDB Length = 451 Score = 103 bits (256), Expect = 3e-22, Method: Composition-based stats. Identities = 46/208 (22%), Positives = 79/208 (37%), Gaps = 25/208 (12%) Query: 201 CACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAY--ETKDA 258 GK Y K ++ + NEK L K+ L + E Sbjct: 96 FKVYALDDGKTYFLKSVKIDA----ESLTEFTNEKDTLSKLG-----RLVGTFFNEQTQV 146 Query: 259 LCLVLTLMNGGDLKFHI----YHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKP 314 ++ T + G DL + ++ F E + +C ++ H +++RDLKP Sbjct: 147 HYILTTFIKGIDLSRYKNALPLNVNLKHFWE--VLGIMISVCHQVKQFHELGLIHRDLKP 204 Query: 315 ENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER---YTFSPDWWAL 371 NI+LD + D G + + + GT Y+APE+ E ++ D +AL Sbjct: 205 GNIMLDADMQCHLVDFGSSS--SDKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFAL 262 Query: 372 GCLLYEMIAGQSPFQQRKKKIKREEVER 399 L E+ +PF+Q K ++ Sbjct: 263 AYSLDELF---NPFRQVKFAKVDIGIKN 287 >5DMZ-A nrPDB Length = 365 Score = 98.1 bits (243), Expect = 1e-20, Method: Composition-based stats. Identities = 46/249 (18%), Positives = 99/249 (39%), Gaps = 36/249 (14%) Query: 191 VLGKGGFGEVCACQ-----VRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN--- 242 +LG+G F +V + + K +K Q++E++ Sbjct: 72 LLGEGAFAQVYEATQGDLNDAKNKQKFVLKV------QKPANPWEFYIGTQLMERLKPSM 125 Query: 243 -SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHI---YHMGQAGFPEARAVFYAAEICCG 298 F + A+ ++ LV L + G L I + + P+ + +A + Sbjct: 126 QHMF-MKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYM 184 Query: 299 LEDLHRERIVYRDLKPENILL-----------DDHGHIRISDLGLAVHV---PEGQTIKG 344 +E +H I++ D+KP+N +L D + + DLG ++ + P+G Sbjct: 185 IEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTA 244 Query: 345 RVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEV 404 + T G+ E++ N+ + + D++ + +Y M+ G + + K + + E L + + Sbjct: 245 KCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGT--YMKVKNEGGECKPEGLFRRL 302 Query: 405 P-EEYSERF 412 P + F Sbjct: 303 PHLDMWNEF 311 >5UU1-A nrPDB Length = 324 Score = 97.4 bits (241), Expect = 1e-20, Method: Composition-based stats. Identities = 49/273 (17%), Positives = 98/273 (35%), Gaps = 40/273 (14%) Query: 170 FLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCAC--QVRATGKMYACKKLEKKRIKKRKG 227 F + K L+ N + + +G GGFG + + K+E + Sbjct: 4 FPEGKVLDDME--GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFS 61 Query: 228 EAMALN------------EKQILEKVNSRFVVSLAYA-----YETKDALCLVLTLMNGGD 270 E E++ L+ + L Y ++ + +V+ + G D Sbjct: 62 ELKFYQRVAKKDCIKKWIERKQLDYLGIP----LFYGSGLTEFKGRSYRFMVMERL-GID 116 Query: 271 LKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILL--DDHGHIRIS 328 L+ F ++ + + LE +H V+ D+K N+LL + + ++ Sbjct: 117 LQK--ISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLA 174 Query: 329 DLGLA-VHVPEGQTI-------KGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIA 380 D GL+ + P G KG GT+ + + + K + D LG + + Sbjct: 175 DYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLC 234 Query: 381 GQSPFQQR--KKKIKREEVERLVKEVPEEYSER 411 G+ P++Q + L+ E+P+ + Sbjct: 235 GKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKW 267 >2RSV-A nrPDB Length = 403 Score = 89.7 bits (221), Expect = 3e-18, Method: Composition-based stats. Identities = 42/272 (15%), Positives = 88/272 (32%), Gaps = 41/272 (15%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMY------ACKKLEKK------------R 221 + K ++ +G+GGFG + + + K R Sbjct: 38 DMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQR 96 Query: 222 IKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKD----ALCLVLTLMNGGDLKFHIYH 277 K + + ++ L+ + + +++ G IY Sbjct: 97 AAKPEQIQKWIRTRK-LKYLGVP---KYWGSGLHDKNGKSYRFMIMD--RFGSDLQKIYE 150 Query: 278 MGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLD--DHGHIRISDLGLA-V 334 F + + I LE +H V+ D+K N+LL+ + + + D GLA Sbjct: 151 ANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYR 210 Query: 335 HVPEG-------QTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQ 387 + PEG + GT+ + + + + D LG + + + G P++ Sbjct: 211 YCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWED 270 Query: 388 R--KKKIKREEVERLVKEVPEEYSERFSPQAR 417 K R+ R + + + F + + Sbjct: 271 NLKDPKYVRDSKIRYRENIASLMDKCFPEKNK 302 >2LAV-A nrPDB Length = 361 Score = 89.3 bits (220), Expect = 4e-18, Method: Composition-based stats. Identities = 42/272 (15%), Positives = 88/272 (32%), Gaps = 41/272 (15%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMY------ACKKLEKK------------R 221 + K ++ +G+GGFG + + + K R Sbjct: 31 DMAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQR 89 Query: 222 IKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKD----ALCLVLTLMNGGDLKFHIYH 277 K + + ++ L+ + + +++ G IY Sbjct: 90 AAKPEQIQKWIRTRK-LKYLGVP---KYWGSGLHDKNGKSYRFMIMD--RFGSDLQKIYE 143 Query: 278 MGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLD--DHGHIRISDLGLA-V 334 F + + I LE +H V+ D+K N+LL+ + + + D GLA Sbjct: 144 ANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYR 203 Query: 335 HVPEG-------QTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQ 387 + PEG + GT+ + + + + D LG + + + G P++ Sbjct: 204 YCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWED 263 Query: 388 R--KKKIKREEVERLVKEVPEEYSERFSPQAR 417 K R+ R + + + F + + Sbjct: 264 NLKDPKYVRDSKIRYRENIASLMDKCFPEKNK 295 >6EAS-A nrPDB Length = 308 Score = 85.8 bits (211), Expect = 5e-17, Method: Composition-based stats. Identities = 42/234 (17%), Positives = 80/234 (34%), Gaps = 32/234 (13%) Query: 224 KRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDAL--CLVLTLMNGGDLKFHIYHMGQA 281 ++ E+ + L KV+ + ++L E + +V G L H++ Sbjct: 81 SKENESQYRKKITNLSKVSHKNFMNLLGYCEEEHPFTRVMVFEYAPNGTLFEHLHVREAE 140 Query: 282 GFPEARAVFYAAEICCGLEDLHRE--RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEG 339 + + I LE +H+ R+ + L D ++SDL Sbjct: 141 KLDWMARLRISMGIAYCLEHMHQLQTPAALRNFDSTTVYLTDDFAAKVSDLEFWNDAKGH 200 Query: 340 QTIKGRVGTVGYMAPEVVKNERYTFSPDWW----ALGCLLYEMIAGQSPFQQRKKKI--- 392 + N FSPD G +L E++ G+ P + + Sbjct: 201 NSTT---------------NNELAFSPDMEDIVRKYGMVLLEILTGRVPSSEDDGPLENW 245 Query: 393 --KREEVERLVKEVPEEYSERFSPQ-ARSLC---SQLLCKDPAERLGCRGGSAR 440 + E ++E+ + F AR+LC + +DP +R + +AR Sbjct: 246 VSRYFEGGMRLEELIDPSIGFFPEDTARALCEVVRSCIDRDPKKRPQMKEVAAR 299 >4O1O-A nrPDB Length = 717 Score = 85.4 bits (210), Expect = 6e-17, Method: Composition-based stats. Identities = 45/270 (16%), Positives = 88/270 (32%), Gaps = 56/270 (20%) Query: 209 GKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN-SRFVVSLAYAYETKDALCLVLTLMN 267 + A K+ + + ++ E L+ + VV+ + L + L L Sbjct: 369 DQEVAVKRFSEGSTRGQQ-------EVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCE 421 Query: 268 GGDLKFHIYHMGQAGFPEAR---AVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGH 324 L+ H+ + P A + + + +LHR ++DL+P+NIL+D Sbjct: 422 Y-TLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNG 480 Query: 325 IRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALG-CLLYEMIAGQS 383 ++D ++ E D ALG +LY + G Sbjct: 481 TFLADFDKSIKWAED---------------------PQKIKRDLEALGLLVLYVVKKGDI 519 Query: 384 PFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCK--DPAERLGCRGGSARE 441 F+ K + E ++ E + R L L + +RL Sbjct: 520 SFETLKNQSFEEVIQGSPDE-----------ETRDLIHHLFHPGDNVEDRLSS------- 561 Query: 442 VKEHPLFKKLNFKRLGAGMLEPPFKPDPQA 471 + HP F ++ + + + D + Sbjct: 562 LLAHPFFWS--WESRYRTLRDVGNESDIKT 589 >6BHC-A nrPDB Length = 438 Score = 84.3 bits (207), Expect = 1e-16, Method: Composition-based stats. Identities = 48/278 (17%), Positives = 100/278 (35%), Gaps = 57/278 (20%) Query: 212 YACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYE----------------T 255 YA K K + K+ + +L +Q L + + Sbjct: 86 YAVKIC-KSKAKESQQYYHSLAVRQSLAV--HFNIQQDCGHFLAEVPNRLLPWEDPSKKQ 142 Query: 256 KDALCLVLTLMNGGDLKFHIY-----HMGQAGFPEARAVFYAAEICCGLEDLHRERIVYR 310 + + ++ + + + H E + ++C GLE L + + Sbjct: 143 RSHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHC 202 Query: 311 DLKPENILLDD---------------------HGHIRISDLGLAV---HVPEGQTIKGRV 346 DL+ EN+LL + +S+ A H+ + + ++ + Sbjct: 203 DLRLENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQ- 261 Query: 347 GTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPE 406 +APE++ +Y D + G L+YEM+ +PF + + +RE + +P Sbjct: 262 ---SRLAPEIITATQY-KKCDEFQTGILIYEMLHLPNPFDENPELKEREYTRADLPRIP- 316 Query: 407 EYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKE 444 + +S + L S LL +P+ER+ A+ + + Sbjct: 317 -FRSPYSRGLQQLASCLLNPNPSERI--LISDAKGILQ 351 >4IX6-A nrPDB Length = 350 Score = 80.4 bits (197), Expect = 2e-15, Method: Composition-based stats. Identities = 59/325 (18%), Positives = 96/325 (29%), Gaps = 82/325 (25%) Query: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF----VV 247 LG G FG V + + L+ + E + E + V Sbjct: 28 LGSGNFGTVFRGVFKGDQDVV----LKNAKADVMAAEELLECEMDVNYHV-HANAKGTCA 82 Query: 248 SLAYAYE----TKDALC--LVLT---LM---NGGDLKFHIYHMGQAGFPEARA------- 288 E + + LM G + + G A A A Sbjct: 83 RFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACADATEL 142 Query: 289 ---VFYAAEICCGLEDLHRERIVYRDLKPENILLDDH--GHIRISDLG---LAVHVPEGQ 340 E+ L LH +V+RD+KP N++ + G +++ DLG L + +PE Sbjct: 143 GVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPETL 202 Query: 341 TIKGRVGT--VGY--------MAP--------------EVVKNERYTFSPDWWALGCLLY 376 G Y + P E K +R+ D W+ GC++ Sbjct: 203 NYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRF----DSWSAGCVML 258 Query: 377 EMI-------AGQSPFQQRKKKIKRE-EVERLVKEVPEEYSERFSPQA-----RSLCSQL 423 ++ AG F K + + R K + + A LC +L Sbjct: 259 QLAVVGLRTDAGLERFLADYKAVGYDVNAFRGEKSGEYGTMDFAALDANGGAGWDLCQRL 318 Query: 424 LCKDPAERLGCRGGSAREVKEHPLF 448 + + R C H F Sbjct: 319 MEAERDARASCEA-----ALSHAFF 338 >6M7Z-A nrPDB Length = 319 Score = 76.6 bits (187), Expect = 3e-14, Method: Composition-based stats. Identities = 58/329 (17%), Positives = 112/329 (34%), Gaps = 58/329 (17%) Query: 167 FNRFLQWKWL----ERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMY---A---CKK 216 W W+ E + ++ + L G F + +T A + Sbjct: 9 LADMTFWSWMSYLKELPDIDESRNPILKRLLSGSF----LRRDGSTTVNVRVPARELVRL 64 Query: 217 LEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLV---LTLMNGGDLKF 273 L ++R+G + + +L+ S + L K + L+ G Sbjct: 65 LSLTPEQQREGVSAKVRLINLLDPKYSVYEPYLYREILPKRSPLLLPSLGEY--RGAFLT 122 Query: 274 HIYHMGQAGF---------PEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGH 324 +I+H G AA + L+ LH +++R ++ + + G Sbjct: 123 YIFHPLSKGLVGDMLETGRSHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDGT 182 Query: 325 IRISDLGLAVHVPEGQTIKGRVGTVGY-MAPEV---------VKNERYTFSPDWWALGCL 374 + + GL P G + VG G APE+ + R+T D ++LG Sbjct: 183 VVLG--GLDTAAPIGTETRLWVGFFGQETAPEIDRNFLADLALTQGRHTVKSDVYSLGVA 240 Query: 375 LYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGC 434 ++ Q E V++ E ++ S +++ ++P R Sbjct: 241 F------RNLVQLLGNGNLGPEDRGAVRQDHLELLDKLS-------QKMIEEEPGNR--- 284 Query: 435 RGGSAREVKEHPLFKKLNFKRLGAGMLEP 463 + E+ + PLF+ LNF+ + G P Sbjct: 285 --PTIEEIMKDPLFEGLNFEDIEEGKARP 311 >4OAU-C nrPDB Length = 699 Score = 76.2 bits (186), Expect = 4e-14, Method: Composition-based stats. Identities = 44/263 (16%), Positives = 84/263 (31%), Gaps = 53/263 (20%) Query: 198 GEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN-SRFVVSLAYAYETK 256 G + + A K +G A E L+ + +V+ + + Sbjct: 357 GGIYLGFY--EKQEVAVKTF-------CEGSPRAQREVSCLQSSRENSHLVTFYGSESHR 407 Query: 257 DALCLVLTLMNGGDLKFHIYHMGQAGFPEAR--AVFYAAEICCGLEDLH-RERIVYRDLK 313 L + +TL H G+ E A + I +++LH ++DL+ Sbjct: 408 GHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQ 467 Query: 314 PENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALG- 372 P+NIL+D ++D + + + + D LG Sbjct: 468 PQNILIDSKKAAHLADFDKS---------------IKW------AGDPQEVKRDLEDLGR 506 Query: 373 CLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERL 432 +LY + G F+ K + EEV +L + + + L +L R Sbjct: 507 LVLYVVKKGSISFEDLKAQ-SNEEVVQLSPD----------EETKDLIHRLFHPGEHVR- 554 Query: 433 GCRGGSAREVKEHPLFKKLNFKR 455 ++ HP F ++ Sbjct: 555 ----DCLSDLLGHPFFW--TWES 571 >6G4J-A nrPDB Length = 315 Score = 75.8 bits (185), Expect = 5e-14, Method: Composition-based stats. Identities = 38/213 (17%), Positives = 71/213 (33%), Gaps = 45/213 (21%) Query: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVN 242 NT+ + LGKG G V + + G A K +E +L+ + Sbjct: 25 GNTYTLRKQLGKGANGIVYLAE-TSDGH-VALKV--------SDDSLSITSEVNVLKSFS 74 Query: 243 SRFVVSLAYAYETKDALCL----------VLTLMNGGDLKFHIYHMGQAGFPEARAVFYA 292 V++ ++ D + + + G L ++ G P Sbjct: 75 KAQSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGAEWIPV-----LM 129 Query: 293 AEICCGLEDLHRERIVYRDLKPENILLD-DHGHIRISDLG----LAVHVPEGQTIKGR-- 345 ++ L LH++ ++ DLKP+N+++ IR D+G + E R Sbjct: 130 IQLLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEYTEFYDRGY 189 Query: 346 --VGTVGYMAPEVVKNERYTFSPDWWALGCLLY 376 GT Y D +A+ ++ Sbjct: 190 WGYGTRK-------AEPSY----DLFAVAMIMI 211 >4CI6-B nrPDB Length = 643 Score = 74.6 bits (182), Expect = 1e-13, Method: Composition-based stats. Identities = 49/308 (15%), Positives = 96/308 (31%), Gaps = 42/308 (13%) Query: 215 KKLEKKRIKKRKGEAMALNEKQILEKV-----NSRFVVSLAY--AYETKDALC--LVLTL 265 K+ +I++ E E + + + + ++ + L++ Sbjct: 68 KQRLVAKIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRYYYALLMDE 127 Query: 266 MNG----GDLKFHIYHMGQAGFP----EARAVFYAAEICCGLEDLHRERIVYRDLKPENI 317 ++G L+ Q F A + L + IV+ D+KP N+ Sbjct: 128 VDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHNDIKPGNV 187 Query: 318 LLDD-HGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV-VKNERYTFSPDWWALGCLL 375 + D G + DLGL H G+ KG T + APE+ V N + D + ++ Sbjct: 188 VFDRASGEPVVIDLGL--HSRSGEQPKGF--TESFKAPELGVGNLGASEKSDVF---LVV 240 Query: 376 YEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQAR-----------SLCSQLL 424 ++ G F++ + + + + E E P R + +L Sbjct: 241 STLLHGIEGFEKDPEIKPNQGLRFITSEPAHVMDENGYPIHRPGIAGVETAYTRFITDIL 300 Query: 425 CKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFS 484 R + E + H A + + DV I + Sbjct: 301 GVSADSR-----PDSNEARLHEFLSDGTIDEESAKQILKDTLTGEMSPLPTDVRRITPYY 355 Query: 485 TVKGVELE 492 + +L Sbjct: 356 LRELSDLL 363 >2JII-A nrPDB Length = 352 Score = 72.3 bits (176), Expect = 5e-13, Method: Composition-based stats. Identities = 30/176 (17%), Positives = 67/176 (38%), Gaps = 13/176 (7%) Query: 249 LAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIV 308 + + LVL + G L+ + + E + A + LE LH V Sbjct: 123 MGFGVHQDKYRFLVLPSL-GRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYV 181 Query: 309 YRDLKPENILLD--DHGHIRISDLGLA-VHVPEGQTIKGRVGTV-------GYMAPEVVK 358 + ++ ENI +D D + ++ G A + P G+ + G+ +++ ++ K Sbjct: 182 HGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHK 241 Query: 359 NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSP 414 + D +LG + + + G P+ E++ + ++ ++ P Sbjct: 242 GCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNT--EDIMKQKQKFVDKPGPFVGP 295 >5VE6-A nrPDB Length = 492 Score = 69.2 bits (168), Expect = 4e-12, Method: Composition-based stats. Identities = 34/121 (28%), Positives = 54/121 (44%), Gaps = 5/121 (4%) Query: 324 HIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQS 383 + IS+ A P G + + +APE+V +Y D + G L+YE++ + Sbjct: 297 RLIISNFLKAKQKPGGTPNLQQKKSQARLAPEIVSASQY-RKFDEFQTGILIYELLHQPN 355 Query: 384 PFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVK 443 PF+ R + RE R P +SP + L LL DP +R+ R G A+ V Sbjct: 356 PFEVRAQ--LRERDYRQEDLPPLPALSLYSPGLQQLAHLLLEADPIKRI--RIGEAKRVL 411 Query: 444 E 444 + Sbjct: 412 Q 412 Score = 55.8 bits (133), Expect = 5e-08, Method: Composition-based stats. Identities = 18/73 (24%), Positives = 31/73 (42%), Gaps = 5/73 (6%) Query: 254 ETKDALCLVLTLMNGGDLKFHIY-----HMGQAGFPEARAVFYAAEICCGLEDLHRERIV 308 + +D + ++ + + H + E R F ++C GLE L I+ Sbjct: 171 QEQDCVVVITREVPHQTASDFVRDSAASHQAEPEAYERRVCFLLLQLCNGLEHLKEHGII 230 Query: 309 YRDLKPENILLDD 321 +RDL EN+LL Sbjct: 231 HRDLCLENLLLVH 243 Score = 32.3 bits (72), Expect = 0.67, Method: Composition-based stats. Identities = 27/140 (19%), Positives = 44/140 (31%), Gaps = 20/140 (14%) Query: 10 TVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRLLFRE 69 + LKA++ GG + KK + L P I + R + G L++ Sbjct: 301 SNFLKAKQKPGGTPNLQQKKSQARLA-PEIVSASQYRK---------FDEFQTGILIYEL 350 Query: 70 FCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPEVPRQL---- 125 P R + E + +D L L L+ P + Sbjct: 351 LHQPNPFEVRA-----QLRERDYRQEDLPPLPALSLYSPGLQQLAHLLLEADPIKRIRIG 405 Query: 126 -VTNCTQRLEQGPCKDLFQE 144 Q L GP ++L Q+ Sbjct: 406 EAKRVLQCLLWGPRRELVQQ 425 >5GZ9-A nrPDB Length = 305 Score = 65.8 bits (159), Expect = 5e-11, Method: Composition-based stats. Identities = 36/211 (17%), Positives = 66/211 (31%), Gaps = 37/211 (17%) Query: 187 RQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFV 246 RQ + +G+G V + + A R+ + + + L+ Q+L+ + S V Sbjct: 37 RQLKRVGEGAVKRVFLSEWKE--HKVAL-----SRLTRLEMKEDFLHGLQMLKSLQSEHV 89 Query: 247 VSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGF----PEARAVFYAAEICCGLEDL 302 V+L E ++ G L + + + + A E + L Sbjct: 90 VTLVGYCEEDGT--ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSIINYL 147 Query: 303 HRERIVYRDLKPEN--------ILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVG---- 350 H + R + N LL + I +DL V + + G Sbjct: 148 HHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLIKCGHRELHGD 207 Query: 351 YMAPEVV------------KNERYTFSPDWW 369 ++APE + Y D W Sbjct: 208 FVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >5GZA-A nrPDB Length = 290 Score = 63.9 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 37/218 (16%), Positives = 68/218 (31%), Gaps = 38/218 (17%) Query: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239 P ++ R+ +++G+G +V + + G+ A + + L+ +L Sbjct: 21 PEIRSGVRRVKLIGQGAVKKVYLSEWQ--GQKVAL-----SVLSSDQYADDFLHGLSMLR 73 Query: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGF----PEARAVFYAAEI 295 + S VV+L E V G + + Q + + A + Sbjct: 74 ALQSSHVVTLVGVCEED--AVFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDY 131 Query: 296 CCGLEDLHRERIVYRDLKPEN--------ILLDDHGHIRISDLGLAVHVPEGQTIKGRVG 347 L LH R + N LL + +DL V +G + + G Sbjct: 132 VAFLAYLHSSPAGIRVMCDSNDLHKTLSQFLLASDMRLLANDLDALPEVEKGG-LGVKCG 190 Query: 348 ----TVGYMAPEVV------------KNERYTFSPDWW 369 T ++APE + Y D W Sbjct: 191 HHELTGDFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >3BYV-A nrPDB Length = 377 Score = 61.9 bits (149), Expect = 7e-10, Method: Composition-based stats. Identities = 45/248 (18%), Positives = 90/248 (36%), Gaps = 39/248 (15%) Query: 213 ACKKLEKKR--------IKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLT 264 A K+++++ IK +K + L + V + + + ++ Sbjct: 116 AIKQMKEEVLRLRLLRGIKNQKQAKVHLRFIFPFDLVKDPQKKKMIRVRLDERDMWVLSR 175 Query: 265 LMNGGDLKFHIYHMGQAGFPEARA---------VFYAAEICCGLEDLHRERIVYRDLKPE 315 ++ ++ G+ + + ++ L LH +V+ L+P Sbjct: 176 FFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPV 235 Query: 316 NILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV------VKNER-----YTF 364 +I+LD G + ++ G V +G + V + G+ PE+ + R TF Sbjct: 236 DIVLDQRGGVFLT--GFEHLVRDGARVVSSV-SRGFEPPELEARRATISYHRDRRTLMTF 292 Query: 365 SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLL 424 S D WALG ++Y + P + E + R K +P+ R+L L Sbjct: 293 SFDAWALGLVIYWIWCADLPITKDAALGGSEWIFRSCKNIPQP--------VRALLEGFL 344 Query: 425 CKDPAERL 432 +RL Sbjct: 345 RYPKEDRL 352 >4CYJ-A nrPDB Length = 438 Score = 60.4 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 35/147 (23%), Positives = 59/147 (40%), Gaps = 18/147 (12%) Query: 197 FGE---VCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAY 253 FG V Q G+ YA ++LE R+ E LN + +K+ + +V++ + Sbjct: 65 FGYPSWVYKAQNSRNGRHYALRRLEGYRL---TNEKAILNVMKDWKKIKNASIVTIHEVF 121 Query: 254 ETKD----ALCLVLTLMNGG-DLKFHIYH-------MGQAGFPEARAVFYAAEICCGLED 301 T++ +L L+ H + PE Y +I L+ Sbjct: 122 TTREFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKT 181 Query: 302 LHRERIVYRDLKPENILLDDHGHIRIS 328 +H R+ R L+P I+L D IR+S Sbjct: 182 IHSNRLAARCLEPSKIILTDINRIRLS 208 >2W1Z-A nrPDB Length = 368 Score = 58.8 bits (141), Expect = 6e-09, Method: Composition-based stats. Identities = 48/305 (15%), Positives = 99/305 (32%), Gaps = 67/305 (21%) Query: 183 KNTFRQYRVLGK--------------GGFGEVCACQVRATGKMY--------------AC 214 + +FR LG+ G + + TG+ A Sbjct: 44 EQSFRVESELGERPRTLVRGPVLRDDGSY-ICLEATDQETGEPLEVHVPYFTERPPSNAI 102 Query: 215 KKLEK--------KRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLM 266 K+L + + IK ++ L ++ V + + + ++ Sbjct: 103 KQLSEQVLRLRLLRGIKNQRQAKAYLRFIFPIDLVKDPKKRKMIRVRLDERDMWVLSRFF 162 Query: 267 NGGDLKFHIYHMGQAGFPEARA---------VFYAAEICCGLEDLHRERIVYRDLKPENI 317 ++ +++ +G + + ++ L +V+ D + NI Sbjct: 163 LYPRMQSNLHILGDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVRNI 222 Query: 318 LLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPE-----VVKNERY-----TFSPD 367 LLD G + ++ G V +G + +G G+ PE ++ ++ TF D Sbjct: 223 LLDQRGGVFLT--GFEHLVRDGASAVSPIG-RGFAPPETTAERMLPYRQHHPTLMTFPFD 279 Query: 368 WWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKD 427 W LG +Y + P + + E + R K +P+ R+L L Sbjct: 280 TWTLGLAIYWIWCADLPNTEDAELGGIEWIYRRCKNIPQP--------VRALLEGFLRYS 331 Query: 428 PAERL 432 +RL Sbjct: 332 KEDRL 336 >3DZO-A nrPDB Length = 413 Score = 58.1 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 42/247 (17%), Positives = 84/247 (34%), Gaps = 38/247 (15%) Query: 213 ACKKLEKKR--------IKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLT 264 A K+++++ IK +K + L + V + + + ++ Sbjct: 121 AIKQMKEEVLRLRLLRGIKNQKQAKVHLRFIFPFDLVKDPQKKKMIRVRLDERDMWVLSR 180 Query: 265 LMNGGDLKFHIYHMGQAGFPEARA---------VFYAAEICCGLEDLHRERIVYRDLKPE 315 ++ ++ G+ + + ++ L LH +V+ L+P Sbjct: 181 FFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPV 240 Query: 316 NILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEV----------VKNERYTFS 365 +I+LD G + ++ G V +G + +G G+ PE TF+ Sbjct: 241 DIVLDQRGGVFLT--GFEHLVRDGASAVSPIG-RGFAPPETTAERMLPFGQHHPTLMTFA 297 Query: 366 PDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLC 425 D W LG +Y + P E + R K +P+ R+L L Sbjct: 298 FDTWTLGLAIYWIWCADLPNTDDAALGGSEWIFRSCKNIPQP--------VRALLEGFLR 349 Query: 426 KDPAERL 432 +RL Sbjct: 350 YPKEDRL 356 >6G38-A nrPDB Length = 357 Score = 57.7 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 37/205 (18%), Positives = 61/205 (29%), Gaps = 56/205 (27%) Query: 163 DSIYFNRFLQWKWLERQP----VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLE 218 +++YF + P + ++ +G+G FGEV T A K + Sbjct: 16 ENLYFQSMGECSQKGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHT--PVAIKIIA 73 Query: 219 -----------KKRIKKRKGEAMALNEKQILE-----------KVNSRFVVS------LA 250 +K ++ E + E +L +NS V L Sbjct: 74 IEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLL 133 Query: 251 YA----------------YETKDALCLVLTLMNGG-DLKFHIYHMGQAGFPEARAVFYAA 293 A + D L +VL GG DL+ + A A Sbjct: 134 KAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLS----SLATAKSILH 189 Query: 294 EICCGLEDLH-RERIVYRDLKPENI 317 ++ L R +RDL N+ Sbjct: 190 QLTASLAVAEASLRFEHRDLHWGNV 214 >4AZW-A nrPDB Length = 471 Score = 55.4 bits (132), Expect = 6e-08, Method: Composition-based stats. Identities = 24/134 (17%), Positives = 49/134 (36%), Gaps = 19/134 (14%) Query: 209 GKMYACKKLEKKR-------IKKRKGEAMALNEKQILEK----VNSRFVVSLAYAYETKD 257 G+ Y CK + ++ + NE + L + ++ V++ E Sbjct: 259 GEDYVCKFFYYDMPHGILTAEESQRNKHELHNEIKFLTQPPAGFDAPAVLA---HGENAQ 315 Query: 258 ALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENI 317 + LV+ + G L + E + L L ++ + D++P N+ Sbjct: 316 SGWLVMEKLPGRLLSDMLAAGE-----EIDREKILGSLLRSLAALEKKGFWHDDVRPWNV 370 Query: 318 LLDDHGHIRISDLG 331 ++D H R+ D G Sbjct: 371 MVDARQHARLIDFG 384 >4AZV-A nrPDB Length = 569 Score = 55.0 bits (131), Expect = 8e-08, Method: Composition-based stats. Identities = 24/134 (17%), Positives = 49/134 (36%), Gaps = 19/134 (14%) Query: 209 GKMYACKKLEKKR-------IKKRKGEAMALNEKQILEK----VNSRFVVSLAYAYETKD 257 G+ Y CK + ++ + NE + L + ++ V++ E Sbjct: 259 GEDYVCKFFYYDMPHGILTAEESQRNKYELHNEIKFLTQPPAGFDAPAVLA---HGENAQ 315 Query: 258 ALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENI 317 + LV+ + G L + E + L L ++ + D++P N+ Sbjct: 316 SGWLVMEKLPGRLLSDMLAAGE-----EIDREKILGSLLRSLAALEKQGFWHDDVRPWNV 370 Query: 318 LLDDHGHIRISDLG 331 ++D H R+ D G Sbjct: 371 MVDARQHARLIDFG 384 >4CZY-B nrPDB Length = 429 Score = 52.7 bits (125), Expect = 4e-07, Method: Composition-based stats. Identities = 26/141 (18%), Positives = 52/141 (36%), Gaps = 17/141 (12%) Query: 201 CACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETK---- 256 Q G+ +A +++E R+ K E +K+ + +V++ A+ T+ Sbjct: 61 YKAQNNKNGRHFALRRIEGYRLTNEKAILNVTKE---WKKIINANIVTVHEAFTTEFFGD 117 Query: 257 DALCLVLTLMNGGD-LKFHI--------YHMGQAGFPEARAVFYAAEICCGLEDLHRERI 307 +L V + L H PE Y +I L +H ++ Sbjct: 118 SSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAKL 177 Query: 308 VYRDLKPENILLDDHGHIRIS 328 R L+ I + ++ IR++ Sbjct: 178 AARCLELSKI-IWENNRIRLA 197 >3ENH-A nrPDB Length = 540 Score = 51.5 bits (122), Expect = 9e-07, Method: Composition-based stats. Identities = 29/177 (16%), Positives = 62/177 (35%), Gaps = 26/177 (14%) Query: 166 YFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRAT---GKMYACK-KLEK-- 219 Y ++ W++ K ++GKG ++ K +++K Sbjct: 319 YRTDMVEVNWIKEIKGKKRKI-PEHLIGKGA-----EADIKRDSYLDFDVIIKERVKKGY 372 Query: 220 --KRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYH 277 +R+ + ++ E + L V + + D ++++ +NG K I Sbjct: 373 RDERLDENIRKSRTAREARYLALVKDFGIPAPYIFDVDLDNKRIMMSYINGKLAKDVIED 432 Query: 278 MGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAV 334 + A +I + LH+ +++ DL N + D + I D GL Sbjct: 433 N----------LDIAYKIGEIVGKLHKNDVIHNDLTTSNFIFDKD--LYIIDFGLGK 477 >3Q60-A nrPDB Length = 371 Score = 51.5 bits (122), Expect = 1e-06, Method: Composition-based stats. Identities = 36/189 (19%), Positives = 63/189 (33%), Gaps = 18/189 (9%) Query: 271 LKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDL 330 L F G G + A++ +L + +V+ P+N+ + G + + D Sbjct: 181 LDFVYVFRGDEGILALHILT--AQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGD- 237 Query: 331 GLAVHVPEGQTIKGRVGTVGYMAPEVVK--NERYTFSPDWWALGCLLYEMIAGQSPF--- 385 ++ G V Y E + +T + + W LG +Y + PF Sbjct: 238 -VSALWKVGTRGPASSVPVTYAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLPFGLV 296 Query: 386 -QQRKKKIKREEVERLVKEVPEEYSE--RFSPQARSLCSQLLCKDPAERLGCRGGSAREV 442 K KR + R+ + ++L + L D RL E Sbjct: 297 TPGIKGSWKRPSL-RVPGTDSLAFGSCTPLPDFVKTLIGRFLNFDRRRRLLPL-----EA 350 Query: 443 KEHPLFKKL 451 E P F +L Sbjct: 351 METPEFLQL 359 >6R5K-O nrPDB Length = 689 Score = 51.1 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 24/136 (17%), Positives = 47/136 (34%), Gaps = 10/136 (7%) Query: 201 CACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKD--- 257 GK Y K+L I K QI K+N ++ ++T Sbjct: 311 FKVFSNYDGKAYVLKRLP--NIDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGD 368 Query: 258 -ALCLVLTLMNGG-DLKFHIY-HMGQAGFPEARAVFYAAEICCGLEDLHRERI-VYRDLK 313 ++CLV L + + + + Y ++ + +H + + + L Sbjct: 369 LSICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGNTLN 428 Query: 314 PENILLD-DHGHIRIS 328 +L+ D G I++S Sbjct: 429 WRKVLITGDPGRIKLS 444 >4WWA-A nrPDB Length = 261 Score = 50.4 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 30/154 (19%), Positives = 52/154 (33%), Gaps = 24/154 (15%) Query: 201 CACQVRATGKMYACK-----KLEKKRIKKRKGEAMALNEKQILEKVN---SRFVVSLAYA 252 + + + + Y K + +I + + LNE ++L K+ V L Sbjct: 38 YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC 97 Query: 253 YETKDALCLVL--TLMNGG----DLKFHIYHMGQAGFPE---ARAVFYAAEICCGLEDLH 303 + L + GG +LK ++ Q + + +I GL LH Sbjct: 98 DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQI--GL--LH 153 Query: 304 RERIVYRDLKPENILLDDHG---HIRISDLGLAV 334 + DL NI+L G + D GL Sbjct: 154 WNDYCHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 >4XR7-L nrPDB Length = 465 Score = 50.4 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 24/136 (17%), Positives = 47/136 (34%), Gaps = 10/136 (7%) Query: 201 CACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKD--- 257 GK Y K+L I K QI K+N ++ ++T Sbjct: 87 FKVFSNYDGKAYVLKRLP--NIDKSMNPNKISKIYQIWSKINCTNLIKFRDIFQTTKFGD 144 Query: 258 -ALCLVLTLMNGG-DLKFHIY-HMGQAGFPEARAVFYAAEICCGLEDLHRERI-VYRDLK 313 ++CLV L + + + + Y ++ + +H + + + L Sbjct: 145 LSICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLSIGNTLN 204 Query: 314 PENILLD-DHGHIRIS 328 +L+ D G I++S Sbjct: 205 WRKVLITGDPGRIKLS 220 >4BWP-A nrPDB Length = 448 Score = 48.8 bits (115), Expect = 6e-06, Method: Composition-based stats. Identities = 43/289 (14%), Positives = 87/289 (30%), Gaps = 76/289 (26%) Query: 201 CACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETK---- 256 TG Y +++ R++ K + ++ +K+ VV L + TK Sbjct: 67 YRATHNTTGYKYCLRRIHGFRLQSTK----CMTLVEMWKKLQHTNVVQLREVFTTKAFGD 122 Query: 257 DALCLVLTLMNG-----------------------GDLKFHIYHMGQAG------FPEAR 287 ++L LV G G+ + + PEA Sbjct: 123 NSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEAT 182 Query: 288 AVFYAAEICCGLEDLHRERIVYRDLKPENILLDDH----GHIRISDLGLAVHVPEGQTIK 343 ++ GL+ +H + + L P I++ ISD+ + Sbjct: 183 IWSIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISDI---TQFDPNASN- 238 Query: 344 GRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKE 403 P + N D ALG L+ + + ++R+ V+ + Sbjct: 239 ----------PLALVNMHQ--QDDLTALGRLVLALACRCL------QSVQRDNVQSSI-- 278 Query: 404 VPEEYSERFSPQARSLCSQLLCKDPAER--------LGCRGGSAREVKE 444 + + +S R+ L + R +G R + + + Sbjct: 279 --DMVTRNYSTDLRNFIVYLFTTN-NRRSVTDLMPMIGARFYTQLDALQ 324 >1TQM-A nrPDB Length = 282 Score = 43.8 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 36/166 (21%), Positives = 60/166 (36%), Gaps = 30/166 (18%) Query: 188 QYRVLGKGGFGEVCACQVRATGKMYACK--KLEKKRIKKRKGEA-------------MAL 232 +++G+G V C G+ K K+ KK K + A Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECV-VKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSAR 152 Query: 233 NEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYA 292 NE + L+K+ V + YA+E +++ L++ +L Sbjct: 153 NEFRALQKLQGLAVPKV-YAWEGN---AVLMELIDAKELYRVRVENPDEVLD-----MIL 203 Query: 293 AEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPE 338 E+ H IV+ DL N+L+ + G I I D +V V E Sbjct: 204 EEVAK---FYH-RGIVHGDLSQYNVLVSEEG-IWIIDFPQSVEVGE 244 >5YK0-A nrPDB Length = 452 Score = 40.4 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 27/179 (15%), Positives = 53/179 (29%), Gaps = 42/179 (23%) Query: 198 GEVCACQVRATGKMYACKKLEKKRIKKRKGEAMAL-NEKQILEKV----NSRFVV----- 247 G+V + G+ A K + + + + +L+++ + + VV Sbjct: 146 GQVHKAIW-SDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204 Query: 248 ----------------SLAYAYETKDAL-----------CLVLTLMNGGDLKFHIYHMGQ 280 + A AY ++ + G + I H Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVVASAPKVVIQEWIEGVPMAEIIRH--G 262 Query: 281 AGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEG 339 AE+ + R +++ D P N +L G + I D G +P G Sbjct: 263 TTEQRDLIGTLLAELT--FDAPRRLGLMHGDAHPGNFMLLPDGRMGIIDFGAVAPMPGG 319 >6FDN-A nrPDB Length = 320 Score = 39.6 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 14/76 (18%), Positives = 27/76 (35%), Gaps = 8/76 (10%) Query: 255 TKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKP 314 + +V+ L+NG L + A + L +++ D Sbjct: 180 DYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVK--------LANHGLIHGDFNE 231 Query: 315 ENILLDDHGHIRISDL 330 N++LD+ HI + D Sbjct: 232 FNLILDESDHITMIDF 247 >6G18-v nrPDB Length = 552 Score = 39.2 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 14/76 (18%), Positives = 27/76 (35%), Gaps = 8/76 (10%) Query: 255 TKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKP 314 + +V+ L+NG L + A + L +++ D Sbjct: 180 DYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVK--------LANHGLIHGDFNE 231 Query: 315 ENILLDDHGHIRISDL 330 N++LD+ HI + D Sbjct: 232 FNLILDESDHITMIDF 247 >6FAI-l nrPDB Length = 425 Score = 38.8 bits (89), Expect = 0.006, Method: Composition-based stats. Identities = 22/171 (12%), Positives = 48/171 (28%), Gaps = 37/171 (21%) Query: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKL------------EKKRIKKRKGEAMAL- 232 + +G G ++ + G K + +KK A + Sbjct: 95 YSVGNTIGVGKESDIYKVSDKN-GNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMH 153 Query: 233 -------NEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPE 285 E Q + + S+ + ++ + +V+ L+ G ++ H Sbjct: 154 LSRLAANKEYQFMSMLYSKGF-KVPEPFDNSRHI-VVMELIEGYPMRRLRKHKNIPKLYS 211 Query: 286 ARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDD------HGHIRISDL 330 F DL +++ D NI++ D + D Sbjct: 212 DLMCFIV--------DLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDF 254 >4BVU-A nrPDB Length = 211 Score = 36.1 bits (82), Expect = 0.048, Method: Composition-based stats. Identities = 23/141 (16%), Positives = 46/141 (32%), Gaps = 22/141 (15%) Query: 188 QYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVV 247 +++G+G E+ ++ KK + + + MA E + Sbjct: 44 LGKLIGQGSTAEIFEDVNDSSALY---KKYDLIGNQYNEILEMAWQESE----------- 89 Query: 248 SLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEI----CCGLEDLH 303 L A+ D +V+ GGD+ + + + I + L+ Sbjct: 90 -LFNAFY-GDEASVVIQY--GGDVYLRMLRVPGTPLSDIDTADIPDNIESLYLQLICKLN 145 Query: 304 RERIVYRDLKPENILLDDHGH 324 I++ DL N+L D Sbjct: 146 ELSIIHYDLNTGNMLYDKESE 166 >6DFL-A nrPDB Length = 259 Score = 35.7 bits (81), Expect = 0.052, Method: Composition-based stats. Identities = 26/169 (15%), Positives = 55/169 (32%), Gaps = 19/169 (11%) Query: 193 GKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSL--- 249 G+G F ++ G+ + K + + A E Q + +++ V ++ Sbjct: 45 GRGYFVKIHRGI--GWGE------IAKNLLTAKLPVLGARQEWQAIRRLHEAGVATMTAV 96 Query: 250 ----AYAYETKDALCLVLT-LMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHR 304 + + +V L DL+ + P + + D+HR Sbjct: 97 AYGERGSDPARQHSFIVTEELAPTVDLEVFSQDWRERPPPPRLKRALVEAVARMVGDMHR 156 Query: 305 ERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTV-GYM 352 + +RD + LL + D L+ V + + R T + Sbjct: 157 AGVNHRDCYICHFLLHTDKPVSADDFRLS--VIDLHRAQTRDATPKRWR 203 >2BV1-A nrPDB Length = 145 Score = 33.8 bits (76), Expect = 0.19, Method: Composition-based stats. Identities = 15/110 (13%), Positives = 39/110 (35%), Gaps = 3/110 (2%) Query: 63 GRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPEVP 122 G+ +F F + + F +Y+ T D ++ + F+ I + Sbjct: 35 GQNVFGSFLKSEFSEEN-IEFWLACEDYKKTESDLLPCKAEEIYKAFVHSDAAKQI-NID 92 Query: 123 RQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQ 172 + + ++++ P F E ++ + + + +L S + L Sbjct: 93 FRTRESTAKKIKA-PTPTCFDEAQKVIYTLMEKDSYPRFLKSDIYLNLLN 141 >3LV4-A nrPDB Length = 456 Score = 31.9 bits (71), Expect = 0.80, Method: Composition-based stats. Identities = 10/45 (22%), Positives = 16/45 (35%), Gaps = 2/45 (4%) Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEA 286 VV ++ L +V +GG F + + GFP Sbjct: 142 KHPNVVDPHTFFDQNGKLWMVYGSYSGG--IFILEMDKKTGFPLP 184 >2X8T-A nrPDB Length = 471 Score = 31.9 bits (71), Expect = 0.88, Method: Composition-based stats. Identities = 10/45 (22%), Positives = 16/45 (35%), Gaps = 2/45 (4%) Query: 242 NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEA 286 VV ++ L +V +GG F + + GFP Sbjct: 165 KHPNVVDPHTFFDKDGKLWMVYGSYSGG--IFILEMNPKTGFPLP 207 >3F7P-A nrPDB Length = 296 Score = 31.5 bits (70), Expect = 1.0, Method: Composition-based stats. Identities = 24/122 (19%), Positives = 47/122 (38%), Gaps = 19/122 (15%) Query: 213 ACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLK 272 A ++ +R + +K K +++ + L L +L +++G L Sbjct: 62 AVIRIADERDRVQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGHNLISLLEVLSGDSLP 119 Query: 273 FHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDD--HGHIRISDL 330 G+ F + + V L+ L +R +K NI DD G+ +++ L Sbjct: 120 ---REKGRMRFHKLQNVQI------ALDYLR-----HRQVKLVNIRNDDIADGNPKLT-L 164 Query: 331 GL 332 GL Sbjct: 165 GL 166 >2VKT-A nrPDB Length = 289 Score = 31.1 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 16/91 (17%), Positives = 29/91 (31%), Gaps = 19/91 (20%) Query: 379 IAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGS 438 + G PF + + + + E L+K+ + +R+ Sbjct: 194 LYGDVPFIEERHRHRFEVNPNLIKQFEQNDLSFVGQDVDG-----------DRM-----E 237 Query: 439 AREVKEHPLFKKLNFKRLGAGMLEPPFKPDP 469 E+ HP F + F + P KP P Sbjct: 238 IIELANHPYFVGVQFHPEFSSR---PMKPSP 265 >2QG7-A nrPDB Length = 458 Score = 31.1 bits (69), Expect = 1.5, Method: Composition-based stats. Identities = 20/106 (18%), Positives = 34/106 (32%), Gaps = 23/106 (21%) Query: 214 CKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDL-K 272 K L + K EK+I + ++ + Y + T + M+G L + Sbjct: 134 AKYLIRLYGPKTDEIINREREKKISCILYNKNIAKKIYVFFTNGR---IEEFMDGYALSR 190 Query: 273 FHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKP-ENI 317 I + I L+ LH D+K EN+ Sbjct: 191 EDIKNPKFQKL-----------IAKNLKLLH-------DIKLNENL 218 >2EG4-A nrPDB Length = 230 Score = 30.7 bits (68), Expect = 1.6, Method: Composition-based stats. Identities = 13/52 (25%), Positives = 20/52 (38%) Query: 438 SAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGV 489 +A E HPL + G + PP P I +E F + +G+ Sbjct: 124 TADEAARHPLLLDVRSPEEFQGKVHPPCCPRGGRIPGSKNAPLELFLSPEGL 175 >6JCV-A nrPDB Length = 333 Score = 30.7 bits (68), Expect = 1.9, Method: Composition-based stats. Identities = 22/132 (16%), Positives = 46/132 (34%), Gaps = 24/132 (18%) Query: 191 VLGKGGFGEVCACQVRATGKMYA---CKKLEKKRIKKRKGEAMALNEK------------ 235 V+G G G V A +R G K + KK E ++E Sbjct: 20 VIGYGNQGRVQATIMRENGLNVIVGNVKDKYYELAKKEGFEVYEIDEAVRRSDVALLLIP 79 Query: 236 -QILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAE 294 +++++V + + + + VL +G ++ F + + + Sbjct: 80 DEVMKEVYEKKIAPVL-----QGKKEFVLDFASGYNVAFGLIRPPK---SVDTIMVAPRM 131 Query: 295 ICCGLEDLHRER 306 + G+ DLH++ Sbjct: 132 VGEGIMDLHKQG 143 >6EF6-A nrPDB Length = 354 Score = 30.3 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 7/28 (25%), Positives = 14/28 (50%), Gaps = 3/28 (10%) Query: 306 RIVYRDLKPENILLDDHG---HIRISDL 330 +++ DL+ N+L+D I + D Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >4Q59-A nrPDB Length = 226 Score = 30.3 bits (67), Expect = 2.2, Method: Composition-based stats. Identities = 21/91 (23%), Positives = 36/91 (39%), Gaps = 17/91 (18%) Query: 244 RFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLH 303 R + L L +L +++G L G+ F + + V L+ L Sbjct: 24 RHISDLYEDLRDGHNLISLLEVLSGDSLP---REKGRMRFHKLQNVQI------ALDYLR 74 Query: 304 RERIVYRDLKPENILLDD--HGHIRISDLGL 332 +R +K NI DD G+ +++ LGL Sbjct: 75 -----HRQVKLVNIRNDDIADGNPKLT-LGL 99 >2IT1-A nrPDB Length = 362 Score = 30.0 bits (66), Expect = 2.7, Method: Composition-based stats. Identities = 17/110 (15%), Positives = 40/110 (36%) Query: 84 LDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPEVPRQLVTNCTQRLEQGPCKDLFQ 143 LD + EV + KR +T +++H + + R V + L+ G +++ Sbjct: 164 LDALLRLEVRAELKRLQKELGITTVYVTHDQAEALAMADRIAVIREGEILQVGTPDEVYY 223 Query: 144 ELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLG 193 + P +++++ + L + P+ K + G Sbjct: 224 KPKYKFVGGFLGNPPMNFVEAKVEDGKLVITEKSKLPIPKQYVEIVKETG 273 >2A6T-A nrPDB Length = 271 Score = 29.6 bits (65), Expect = 3.9, Method: Composition-based stats. Identities = 11/89 (12%), Positives = 28/89 (31%), Gaps = 1/89 (1%) Query: 104 QLTQNFLSHTGPDLIPEVPRQ-LVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYL 162 L I +P + + + +++ R ++ L + Sbjct: 11 ATFSQVLDDLSARFILNLPAEEQSSVERLCFQIEQAHWFYEDFIRAQNDQLPSLGLRVFS 70 Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRV 191 ++ + L WKW + + F +Y+ Sbjct: 71 AKLFAHCPLLWKWSKVHEEAFDDFLRYKT 99 >5J3Y-B nrPDB Length = 242 Score = 29.6 bits (65), Expect = 4.4, Method: Composition-based stats. Identities = 11/89 (12%), Positives = 28/89 (31%), Gaps = 1/89 (1%) Query: 104 QLTQNFLSHTGPDLIPEVPRQ-LVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYL 162 L I +P + + + +++ R ++ L + Sbjct: 6 ATFSQVLDDLSARFILNLPAEEQSSVERLCFQIEQAHWFYEDFIRAQNDQLPSLGLRVFS 65 Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRV 191 ++ + L WKW + + F +Y+ Sbjct: 66 AKLFAHCPLLWKWSKVHEEAFDDFLRYKT 94 >2QKL-B nrPDB Length = 95 Score = 29.2 bits (64), Expect = 5.3, Method: Composition-based stats. Identities = 11/89 (12%), Positives = 28/89 (31%), Gaps = 1/89 (1%) Query: 104 QLTQNFLSHTGPDLIPEVPRQ-LVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYL 162 L I +P + + + +++ R ++ L + Sbjct: 6 ATFSQVLDDLSARFILNLPAEEQSSVERLCFQIEQAHWFYEDFIRAQNDQLPSLGLRVFS 65 Query: 163 DSIYFNRFLQWKWLERQPVTKNTFRQYRV 191 ++ + L WKW + + F +Y+ Sbjct: 66 AKLFAHCPLLWKWSKVHEEAFDDFLRYKT 94 >1IU8-A nrPDB Length = 206 Score = 28.8 bits (63), Expect = 6.9, Method: Composition-based stats. Identities = 12/50 (24%), Positives = 19/50 (38%) Query: 377 EMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCK 426 ++ G PF K + VE L + +PE E + +LL Sbjct: 3 ILLTGFEPFGGDDKNPTMDIVEALSERIPEVVGEILPVSFKRAREKLLKV 52 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.141 0.409 Lambda K H 0.267 0.0434 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 23,938,599 Number of Sequences: 36641 Number of extensions: 1036144 Number of successful extensions: 6727 Number of sequences better than 10.0: 515 Number of HSP's better than 10.0 without gapping: 921 Number of HSP's successfully gapped in prelim test: 69 Number of HSP's that attempted gapping in prelim test: 2690 Number of HSP's gapped (non-prelim): 1119 length of query: 576 length of database: 10,336,785 effective HSP length: 102 effective length of query: 474 effective length of database: 6,599,403 effective search space: 3128117022 effective search space used: 3128117022 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 62 (28.4 bits)