BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P42943 (550 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5GW4-h nrPDB 1129 0.0 4B2T-H nrPDB 702 0.0 3J1E-A nrPDB 345 3e-95 1A6E-A nrPDB 344 5e-95 4XCG-B nrPDB 328 3e-90 4XCI-A nrPDB 322 3e-88 3RUW-A nrPDB 313 2e-85 3J1C-A nrPDB 308 3e-84 1A6D-B nrPDB 306 1e-83 1Q3S-A nrPDB 305 2e-83 3IYF-A nrPDB 295 3e-80 3AQ1-B nrPDB 293 2e-79 4B2T-G nrPDB 292 2e-79 4B2T-A nrPDB 287 7e-78 5GW5-g nrPDB 275 3e-74 4V94-A nrPDB 272 3e-73 4B2T-B nrPDB 271 5e-73 4V8R-AB nrPDB 267 9e-72 4B2T-D nrPDB 267 1e-71 5UYZ-A nrPDB 258 3e-69 4V8R-AG nrPDB 250 9e-67 4V8R-AE nrPDB 244 8e-65 5GW4-d nrPDB 227 8e-60 4B2T-Z nrPDB 211 5e-55 5GW5-q nrPDB 197 1e-50 4B2T-Q nrPDB 188 5e-48 5GW5-z nrPDB 188 6e-48 5X9V-A nrPDB 152 3e-37 1GN1-A nrPDB 84 2e-16 4V4O-A nrPDB 82 6e-16 1IOK-A nrPDB 75 7e-14 1ASS-A nrPDB 74 2e-13 1E0R-B nrPDB 73 3e-13 4AAR-A nrPDB 54 2e-07 1SJP-A nrPDB 50 3e-06 5DA8-A nrPDB 48 1e-05 4PJ1-A nrPDB 48 1e-05 5CDI-A nrPDB 42 8e-04 5DA0-A nrPDB 30 2.7 3NO5-A nrPDB 30 3.9 2AWD-A nrPDB 29 6.7 3H1T-A nrPDB 28 8.0 >5GW4-h nrPDB Length = 550 Score = 1129 bits (2919), Expect = 0.0, Method: Compositional matrix adjust. Identities = 550/550 (100%), Positives = 550/550 (100%) Query: 1 MNFGSQTPTIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKT 60 MNFGSQTPTIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKT Sbjct: 1 MNFGSQTPTIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKT 60 Query: 61 TISNDGATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGI 120 TISNDGATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGI Sbjct: 61 TISNDGATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGI 120 Query: 121 SSHLIMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVK 180 SSHLIMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVK Sbjct: 121 SSHLIMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVK 180 Query: 181 MCVDAVLSLDRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPK 240 MCVDAVLSLDRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPK Sbjct: 181 MCVDAVLSLDRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPK 240 Query: 241 ILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIG 300 ILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIG Sbjct: 241 ILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIG 300 Query: 301 DLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSE 360 DLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSE Sbjct: 301 DLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSE 360 Query: 361 RYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEV 420 RYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEV Sbjct: 361 RYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEV 420 Query: 421 SKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYG 480 SKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYG Sbjct: 421 SKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYG 480 Query: 481 VVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESANAGMMPPQ 540 VVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESANAGMMPPQ Sbjct: 481 VVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESANAGMMPPQ 540 Query: 541 GAGRGRGMPM 550 GAGRGRGMPM Sbjct: 541 GAGRGRGMPM 550 >4B2T-H nrPDB Length = 543 Score = 702 bits (1811), Expect = 0.0, Method: Compositional matrix adjust. Identities = 337/524 (64%), Positives = 418/524 (79%), Gaps = 3/524 (0%) Query: 8 PT-IVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDG 66 PT +++LKEGTD+SQG Q++SNI+AC + EA++ TLGP G D LIV K TISNDG Sbjct: 3 PTPVILLKEGTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDG 62 Query: 67 ATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIM 126 ATILKLLDVVHPAAKTLVDI+++QDAEVGDGTTSVT+LA E +K+ KP++EEG+ +I+ Sbjct: 63 ATILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIII 122 Query: 127 KGYRKAVSLAVEKINELAVDITSE-KSSGRELLERCARTAMSSKLIHNNADFFVKMCVDA 185 + +R A LAV KI E+AV + E K R+LLE+CA TA+SSKLI FF KM VDA Sbjct: 123 RAFRTATQLAVNKIKEIAVTVKKEDKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDA 182 Query: 186 VLSLDRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLN 245 V+ LD + L K+IGIKK+ GGA+EES + GVAFKKTFSYAGFE QPKK++NP I LN Sbjct: 183 VMMLD-DLLQLKMIGIKKVQGGALEESQLVAGVAFKKTFSYAGFEMQPKKYHNPMIALLN 241 Query: 246 VELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQ 305 VELELKAEKDNAE+RV VEDYQAIVDAEW ++++KL ++ +GA +VLSKLPIGD+ATQ Sbjct: 242 VELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGDVATQ 301 Query: 306 FFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNLF 365 +FADR++FCAGRV +D+ R + A GGSIQ++ + + + LG C +FEE QIG ERYN F Sbjct: 302 YFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALSSDVLGRCQVFEETQIGGERYNFF 361 Query: 366 QGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLR 425 GCP+AKTCT++LRGGAEQ + E ERSLHDAIMIV+RA++N +VAGGGA EME+SK LR Sbjct: 362 TGCPKAKTCTIILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLR 421 Query: 426 DYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFET 485 DYS+TI GKQQ++I A+AKALE+IPRQLC+NAGFDA ILNKLR H++G WYGV T Sbjct: 422 DYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGMWYGVDINT 481 Query: 486 ENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGS 529 E+I DNF FVWEPA+V+INAL +A+EA LI+SVDETI N S Sbjct: 482 EDIADNFEAFVWEPAMVRINALTAASEAACLIVSVDETIKNPRS 525 >3J1E-A nrPDB Length = 553 Score = 345 bits (885), Expect = 3e-95, Method: Compositional matrix adjust. Identities = 193/535 (36%), Positives = 313/535 (58%), Gaps = 15/535 (2%) Query: 10 IVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATI 69 +++LKEG+ + GK + +NI A AV+EALK T GP G D ++V S TI+NDGATI Sbjct: 16 VIILKEGSSRTYGKEAVRANIAAVKAVEEALKSTYGPRGMDKMLVDSLGDITITNDGATI 75 Query: 70 LKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGY 129 L +D+ HPAAK LV I++ QD E DGT + I +GEL+K+A+ L + + +I+ GY Sbjct: 76 LDKMDLQHPAAKLLVQIAKGQDEETADGTKTAVIFSGELVKKAEDLLYKDVHPTIIISGY 135 Query: 130 RKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAV--- 186 +KA +A++ I ELA ++ + +LL + A T++SSK + ++ + V AV Sbjct: 136 KKAEEVALQTIQELAQTVSINDT---DLLRKIAMTSLSSKAVAGAREYIADIVVKAVTQV 192 Query: 187 --LSLDRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSL 244 L D+ +D I I K GG++ ++ + G+ K + G PK+ N KI + Sbjct: 193 AELRGDKWYVDLDNIQIVKKAGGSINDTQLVYGIVVDKEVVHPGM---PKRLENAKIALI 249 Query: 245 NVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLAT 304 + LE++ + +AE+R+ Q +D E LI EK+ ++ TGAN+++ + I ++A Sbjct: 250 DASLEVEKPELDAEIRINDPTQMQKFLDEEENLIKEKVDKILATGANVIICQKGIDEVAQ 309 Query: 305 QFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNL 364 + A + + R D+ ++ +A GG + S +I + LG +L EE ++G ++ Sbjct: 310 SYLAKKGVLAVRRAKKSDLEKLARATGGRVVSNIDEISEQDLGYASLIEERKVGEDKMVF 369 Query: 365 FQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCL 424 +G K+ ++L+RGG E+++ E ER+L DA+ V +++ +AGGGA E+E++K L Sbjct: 370 VEGAKNPKSISILIRGGLERLVDETERALRDALGTVADVIKDGRAIAGGGAVEIEIAKKL 429 Query: 425 RDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAH-SKGEKWYGVVF 483 R Y+ + GK+Q+ + A+A ALE + L ENAGFD I++L KLR H ++ KWYG+ Sbjct: 430 RKYAPQVGGKEQLAVEAYANALESLVSILIENAGFDPIDLLMKLRSTHENENNKWYGIDL 489 Query: 484 ETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETIT---NKGSESANAG 535 D + K V EPALVK+NA+ +ATEA L+L +D+ ++ G ES G Sbjct: 490 YAGQPVDMWQKGVIEPALVKMNAIKAATEAATLVLRIDDVVSAGKKSGGESKTPG 544 >1A6E-A nrPDB Length = 545 Score = 344 bits (883), Expect = 5e-95, Method: Compositional matrix adjust. Identities = 201/529 (37%), Positives = 305/529 (57%), Gaps = 14/529 (2%) Query: 6 QTPTIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISND 65 Q P I+VLKEGT QGK +NI A A+ +A++ TLGP G D ++V S ISND Sbjct: 5 QVP-ILVLKEGTQREQGKNAQRNNIEAAKAIADAVRTTLGPKGMDKMLVDSIGDIIISND 63 Query: 66 GATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLI 125 GATILK +DV HP AK +V++S+AQD VGDGTT+ +L+GEL+K+A+ L++G+ +I Sbjct: 64 GATILKEMDVEHPTAKMIVEVSKAQDTAVGDGTTTAVVLSGELLKQAETLLDQGVHPTVI 123 Query: 126 MKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDA 185 GYR AV+ A + I+E+A EKS+ L + A TA+S K + DF + V A Sbjct: 124 SNGYRLAVNEARKIIDEIA-----EKSTDDATLRKIALTALSGKNTGLSNDFLADLVVKA 178 Query: 186 VLSL-----DRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPK 240 V ++ + +D I + K GG++ ++ FI+G+ K ++ + P N K Sbjct: 179 VNAVAEVRDGKTIVDTANIKVDKKNGGSVNDTQFISGIVIDKEKVHS---KMPDVVKNAK 235 Query: 241 ILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIG 300 I ++ LE+K + A+V++ Q ++ E + + +++++GAN+VL + I Sbjct: 236 IALIDSALEIKKTEIEAKVQISDPSKIQDFLNQETNTFKQMVEKIKKSGANVVLCQKGID 295 Query: 301 DLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSE 360 D+A + A I+ RV DM ++ +A G I + D+ P LG EE +IG + Sbjct: 296 DVAQHYLAKEGIYAVRRVKKSDMEKLAKATGAKIVTDLDDLTPSVLGEAETVEERKIGDD 355 Query: 361 RYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEV 420 R GC K ++L+RGG + V++EVER+L+DAI +V ++ + GGGA E E+ Sbjct: 356 RMTFVMGCKNPKAVSILIRGGTDHVVSEVERALNDAIRVVAITKEDGKFLWGGGAVEAEL 415 Query: 421 SKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYG 480 + L Y+ ++ G++Q+ I AFAKALE+IPR L ENAG D I L KL+ KG G Sbjct: 416 AMRLAKYANSVGGREQLAIEAFAKALEIIPRTLAENAGIDPINTLIKLKADDEKGRISVG 475 Query: 481 VVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGS 529 V + +GD AK V +P VK +AL SA E +IL +D+ I +K S Sbjct: 476 VDLDNNGVGDMKAKGVVDPLRVKTHALESAVEVATMILRIDDVIASKKS 524 >4XCG-B nrPDB Length = 557 Score = 328 bits (841), Expect = 3e-90, Method: Compositional matrix adjust. Identities = 189/532 (35%), Positives = 307/532 (57%), Gaps = 15/532 (2%) Query: 10 IVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATI 69 +++LKEG+ + GK + +NI A A++EALK T GP G D ++V S TI+NDGATI Sbjct: 18 VIILKEGSSRTYGKEALRANIAAVKAIEEALKSTYGPRGMDKMLVDSLGDITITNDGATI 77 Query: 70 LKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGY 129 L +D+ HP K LV I++ QD E DGT + ILAGEL K+A+ L + I +I+ GY Sbjct: 78 LDKMDLQHPTGKLLVQIAKGQDEETADGTKTAVILAGELAKKAEDLLYKEIHPTIIVSGY 137 Query: 130 RKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAV--- 186 +KA +A++ I E+A +T + ++L + A T++ SK + ++ + V AV Sbjct: 138 KKAEEIALKTIQEIAQPVTINDT---DVLRKVALTSLGSKAVAGAREYLADLVVKAVAQV 194 Query: 187 --LSLDRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSL 244 L D+ +D + I K GG++ ++ + G+ K + G PK+ N KI L Sbjct: 195 AELRGDKWYVDLDNVQIVKKHGGSVNDTQLVYGIVVDKEVVHPGM---PKRIENAKIALL 251 Query: 245 NVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLAT 304 + LE++ + +AE+R+ ++ E ++ EK+ ++ TGAN+V+ + I ++A Sbjct: 252 DASLEVEKPELDAEIRINDPTQMHKFLEEEENILKEKVDKIAATGANVVICQKGIDEVAQ 311 Query: 305 QFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNL 364 + A + I R D+ ++ +A GG + S ++ + LG AL EE ++G ++ Sbjct: 312 HYLAKKGILAVRRAKKSDLEKLARATGGRVISNIDELTSQDLGYAALVEERKVGEDKMVF 371 Query: 365 FQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCL 424 +G K+ ++L+RGG E+V+ E ER+L DA+ V +++ VAGGGA E+E++K L Sbjct: 372 VEGAKNPKSVSILIRGGLERVVDETERALRDALGTVADVIRDGRAVAGGGAVEIEIAKRL 431 Query: 425 RDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAH-SKGEKWYGVVF 483 R Y+ + GK+Q+ I A+A A+E + L ENAG D I+ L +LR H ++ KWYG+ Sbjct: 432 RKYAPQVGGKEQLAIEAYANAIEGLIMILAENAGLDPIDKLMQLRSLHENETNKWYGLNL 491 Query: 484 ETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETIT---NKGSESA 532 T N D + V EPALVK+NA+ +ATEA L+L +D+ + GSE + Sbjct: 492 FTGNPEDMWKLGVIEPALVKMNAVKAATEAVTLVLRIDDIVAAGKKSGSEPS 543 >4XCI-A nrPDB Length = 559 Score = 322 bits (825), Expect = 3e-88, Method: Compositional matrix adjust. Identities = 189/527 (35%), Positives = 309/527 (58%), Gaps = 15/527 (2%) Query: 10 IVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATI 69 +++LKEGT + G+ + +NI A + E L+ +LGP G D +++ S TI+NDGATI Sbjct: 5 VLLLKEGTSRTTGRDALRNNILAAKTLAEMLRSSLGPKGLDKMLIDSFGDVTITNDGATI 64 Query: 70 LKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGY 129 +K +++ HPAAK LV+ ++AQDAEVGDGTTS +LAG L+++A+ L++ I +I++GY Sbjct: 65 VKDMEIQHPAAKLLVEAAKAQDAEVGDGTTSAVVLAGALLEKAESLLDQNIHPTIIIEGY 124 Query: 130 RKAVSLAVEKINELA--VDITSEKSS-GRELLERCARTAMSSKLIHNNADF--FVKMCVD 184 +KA + A+E + +L +DI SS R+ L + A T ++SK I A+ + M +D Sbjct: 125 KKAYNKALELLPQLGTRIDIKDLNSSVARDTLRKIAFTTLASKFIAEGAELNKIIDMVID 184 Query: 185 AVLSLDR------NDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNN 238 A++++ ++ LI I K GG++E+S+ + G+ K + G P++ Sbjct: 185 AIVNVAEPLPNGGYNVSLDLIKIDKKKGGSIEDSVLVKGLVLDKEVVHPGM---PRRVTK 241 Query: 239 PKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLP 298 KI L+ LE++ + +A++ + E +A +D E + + + + ++ GAN+V+ + Sbjct: 242 AKIAVLDAALEVEKPEISAKISITSPEQIKAFLDEESKYLKDMVDKLASIGANVVICQKG 301 Query: 299 IGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIG 358 I D+A F A + I RV D+ ++ +A+G I S+ D PE LG L EE ++G Sbjct: 302 IDDIAQHFLAKKGILAVRRVKRSDIEKLEKALGARIISSIKDATPEDLGYAELVEERRVG 361 Query: 359 SERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEM 418 +++ +G K +LLRG + + E ERS++DA+ ++ L +I+ GGGA E+ Sbjct: 362 NDKMVFIEGAKNLKAVNILLRGSNDMALDEAERSINDALHALRNILLEPVILPGGGAIEL 421 Query: 419 EVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKW 478 E++ LR+Y++++ GK+Q+ I AFA ALE IP L E AG +AI L LR H+KG Sbjct: 422 ELAMKLREYARSVGGKEQLAIEAFADALEEIPLILAETAGLEAISSLMDLRARHAKGLSN 481 Query: 479 YGV-VFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETI 524 GV V + + D +A + EP VK L SATEA IL +D+ I Sbjct: 482 TGVDVIGGKIVDDVYALNIIEPIRVKSQVLKSATEAATAILKIDDLI 528 >3RUW-A nrPDB Length = 543 Score = 313 bits (801), Expect = 2e-85, Method: Compositional matrix adjust. Identities = 182/523 (34%), Positives = 301/523 (57%), Gaps = 11/523 (2%) Query: 5 SQTPTIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISN 64 SQ P VL E G+ NI A + E ++ TLGP G D ++V ++N Sbjct: 2 SQQPG--VLPENMKRYMGRDAQRMNILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVVTN 59 Query: 65 DGATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHL 124 DG TIL+ + V HPAAK L+++++ Q+ EVGDGTT+ ++AGEL+++A+ L++ + + Sbjct: 60 DGVTILREMSVEHPAAKMLIEVAKTQEKEVGDGTTTAVVVAGELLRKAEELLDQNVHPTI 119 Query: 125 IMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVD 184 ++KGY+ A A E + +A ++ ++ +E+L + A T+++ K + ++ V+ Sbjct: 120 VVKGYQAAAQKAQELLKTIACEVGAQD---KEILTKIAMTSITGKGAEKAKEKLAEIIVE 176 Query: 185 AVLSL--DRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKIL 242 AV ++ D +D LI I+K G +++++ I GV K A Q PKK + KI Sbjct: 177 AVSAVVDDEGKVDKDLIKIEKKSGASIDDTELIKGVLVDKERVSA---QMPKKVTDAKIA 233 Query: 243 SLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDL 302 LN +E+K + +AE+R+ ++ E +++ + + +++ +GAN++ + I DL Sbjct: 234 LLNCAIEIKETETDAEIRITDPAKLMEFIEQEEKMLKDMVAEIKASGANVLFCQKGIDDL 293 Query: 303 ATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERY 362 A + A I A RV DM ++ +A G ++ + + + + LG L EE +I + Sbjct: 294 AQHYLAKEGIVAARRVKKSDMEKLAKATGANVIAAIAALSAQDLGDAGLVEERKISGDSM 353 Query: 363 NLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSK 422 + C K T+L+RG E VI EV R++ DA+ +V +++ IV+GGG+TE+E+S Sbjct: 354 IFVEECKHPKAVTMLIRGTTEHVIEEVARAVDDAVGVVGCTIEDGRIVSGGGSTEVELSM 413 Query: 423 CLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAH-SKGEKWYGV 481 LR+Y++ I+G++Q+ + AFA ALEVIPR L ENAG DAIEIL K+R AH S G K G+ Sbjct: 414 KLREYAEGISGREQLAVRAFADALEVIPRTLAENAGLDAIEILVKVRAAHASNGNKCAGL 473 Query: 482 VFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETI 524 T + D V EP VK A+ SA E+T ++L +D+ I Sbjct: 474 NVFTGAVEDMCENGVVEPLRVKTQAIQSAAESTEMLLRIDDVI 516 >3J1C-A nrPDB Length = 563 Score = 308 bits (790), Expect = 3e-84, Method: Compositional matrix adjust. Identities = 185/528 (35%), Positives = 303/528 (57%), Gaps = 17/528 (3%) Query: 10 IVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATI 69 +++ KEGT + G+ + +NI A + E L+ +LGP G D +++ S TI+NDGATI Sbjct: 7 VLLFKEGTSRNSGRDALKNNILAARTLAEMLRSSLGPKGLDKMLIDSFGDVTITNDGATI 66 Query: 70 LKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGY 129 +K +++ HPAAK LV+ ++AQD+EVGDGTTS +LAG +++A+ +++ I +I++G+ Sbjct: 67 VKEMEIQHPAAKLLVEAAKAQDSEVGDGTTSAVVLAGLFLEKAESLVDQNIHPTIIIEGF 126 Query: 130 RKAVSLAVEKINELA--VDITSEKS-SGRELLERCARTAMSSKLIHNNADF--FVKMCVD 184 +KA + ++E + +LA VD++ S + R+ L++ T MSSK + + + + +D Sbjct: 127 KKAFNKSLELLPQLATKVDVSDLNSATARDALKKIVYTTMSSKFMAEGEELNKIMDIVID 186 Query: 185 AVLSLDRNDLDD-------KLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFN 237 AV ++ L D LI I K GG +E+S I G+ K +AG P++ Sbjct: 187 AVTTV-AEPLPDGGYNVSLDLIKIDKKKGGTIEDSQLIRGIVLDKEVVHAGM---PRRVE 242 Query: 238 NPKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKL 297 KI L+ LE++ + +A++ + + +A +D E + + + + ++ GAN+V+ + Sbjct: 243 KAKIAVLDASLEVEKPEISAKISITSPDQIKAFLDEEAKYLKDMVDKLASIGANVVICQK 302 Query: 298 PIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQI 357 I D+A F A R I RV D+ ++ +A+G I S+ D PE LG L EE ++ Sbjct: 303 GIDDIAQHFLAKRGILAVRRVKRSDIEKLEKALGARIISSIKDATPEDLGYAELVEERKV 362 Query: 358 GSERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATE 417 G+++ +G K +LLRG + + E ERS++DA+ ++ L IV GGGA E Sbjct: 363 GNDKMVFIEGAKNPKAVNILLRGSNDMALDEAERSINDALYSLRNILMEPYIVPGGGAIE 422 Query: 418 MEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEK 477 +E+S LR+Y++++ GK+Q+ I A+A ALE IP L E AG + I L LR H+KG Sbjct: 423 LELSARLREYARSVGGKEQLAIEAYADALEEIPMILAETAGLEPISALMDLRARHAKGLT 482 Query: 478 WYGV-VFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETI 524 GV V + I D ++ V EP V L SATEA I+ +D+ I Sbjct: 483 NCGVDVINGKIIDDIYSINVVEPIRVTRQVLKSATEAATSIMKIDDLI 530 >1A6D-B nrPDB Length = 543 Score = 306 bits (785), Expect = 1e-83, Method: Compositional matrix adjust. Identities = 190/522 (36%), Positives = 300/522 (57%), Gaps = 15/522 (2%) Query: 10 IVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATI 69 I +LKEGT GK + NI A +A+ +++ +LGP G D ++V S I+NDG TI Sbjct: 7 IFILKEGTKRESGKDAMKENIEAAIAISNSVRSSLGPRGMDKMLVDSLGDIVITNDGVTI 66 Query: 70 LKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGY 129 LK +DV HPAAK +V++S+ QD+ VGDGTT+ I+AG L+++A+ + + + +I +GY Sbjct: 67 LKEMDVEHPAAKMMVEVSKTQDSFVGDGTTTAVIIAGGLLQQAQGLINQNVHPTVISEGY 126 Query: 130 RKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSL 189 R A A I+E++ I +++ + LL + A+T+++SK D ++ +AV S+ Sbjct: 127 RMASEEAKRVIDEISTKIGADE---KALLLKMAQTSLNSKSASVAKDKLAEISYEAVKSV 183 Query: 190 D--RN-----DLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKIL 242 R+ D D+ I + K GGA++++ ING+ K + G P + KI Sbjct: 184 AELRDGKYYVDFDN--IQVVKKQGGAIDDTQLINGIIVDKEKVHPGM---PDVVKDAKIA 238 Query: 243 SLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDL 302 L+ LE+K + + +R+E Q + E ++ E + +++ GAN+V+++ I D+ Sbjct: 239 LLDAPLEIKKPEFDTNLRIEDPSMIQKFLAQEENMLREMVDKIKSVGANVVITQKGIDDM 298 Query: 303 ATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERY 362 A + + I+ RV DM+++ +A G SI ST +I LGT E++++G + Sbjct: 299 AQHYLSRAGIYAVRRVKKSDMDKLAKATGASIVSTIDEISSSDLGTAERVEQVKVGEDYM 358 Query: 363 NLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSK 422 GC K ++L+RG E V+ E+ERS+ D++ +V AL++ AGGGAT E++ Sbjct: 359 TFVTGCKNPKAVSILVRGETEHVVDEMERSITDSLHVVASALEDGAYAAGGGATAAEIAF 418 Query: 423 CLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVV 482 LR Y++ I G+QQ+ I FA A+E IPR L ENAG D I+IL KLR H+KG K YG+ Sbjct: 419 RLRSYAQKIGGRQQLAIEKFADAIEEIPRALAENAGLDPIDILLKLRAEHAKGNKTYGIN 478 Query: 483 FETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETI 524 T I D V EP V A+ SATEA +IL +D+ I Sbjct: 479 VFTGEIEDMVKNGVIEPIRVGKQAIESATEAAIMILRIDDVI 520 >1Q3S-A nrPDB Length = 548 Score = 305 bits (782), Expect = 2e-83, Method: Compositional matrix adjust. Identities = 180/529 (34%), Positives = 295/529 (55%), Gaps = 17/529 (3%) Query: 10 IVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATI 69 +V+L EGT G+ NI A + E ++ TLGP G D ++V S ++ND ATI Sbjct: 9 VVILPEGTQRYVGRDAQRLNILAARIIAETVRTTLGPKGMDKMLVDSLGDIVVTNDCATI 68 Query: 70 LKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGY 129 L +D+ HPAAK +V++++ QD E GDGTT+ ++AGEL+++A+ L++ I +I+KGY Sbjct: 69 LDKIDLQHPAAKMMVEVAKTQDKEAGDGTTTAVVIAGELLRKAEELLDQNIHPSIIIKGY 128 Query: 130 RKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSL 189 A A E ++E+A+ + + E L + A T+++ K ++ + K+ V+AV + Sbjct: 129 ALAAEKAQEILDEIAIRVDPDDE---ETLLKIAATSITGKNAESHKELLAKLAVEAVKQV 185 Query: 190 DRN-------DLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKIL 242 DLD+ I +K G +EES + GV K + + PK+ N KI Sbjct: 186 AEKKDGKYVVDLDN--IKFEKKAGEGVEESELVRGVVIDKEVVHP---RMPKRVENAKIA 240 Query: 243 SLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDL 302 +N LE+K + +A++ + + + ++ E +++ + + + +TGAN+V + I DL Sbjct: 241 LINEALEVKKTETDAKINITSPDQLMSFLEQEEKMLKDMVDHIAQTGANVVFVQKGIDDL 300 Query: 303 ATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERY 362 A + A I RV DM ++ +A G I + D+ PE LG + EE ++ E Sbjct: 301 AQHYLAKYGIMAVRRVKKSDMEKLAKATGAKIVTNVKDLTPEDLGYAEVVEERKLAGENM 360 Query: 363 NLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSK 422 +GC K T+L+RGG E VI EVER+L DA+ +VK +++ ++ GGA E+E++ Sbjct: 361 IFVEGCKNPKAVTILIRGGTEHVIDEVERALEDAVKVVKDVMEDGAVLPAGGAPEIELAI 420 Query: 423 CLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGV- 481 L +Y+K + GK+ + I FA AL++IP+ L ENAG D +E+L K+ H G+ Sbjct: 421 RLDEYAKQVGGKEALAIENFADALKIIPKTLAENAGLDTVEMLVKVISEHKNRGLGIGID 480 Query: 482 VFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSE 530 VFE + D K + EP VK A+ SA+EA +IL +D+ I K ++ Sbjct: 481 VFEGKP-ADMLEKGIIEPLRVKKQAIKSASEAAIMILRIDDVIAAKATK 528 >3IYF-A nrPDB Length = 521 Score = 295 bits (756), Expect = 3e-80, Method: Compositional matrix adjust. Identities = 182/523 (34%), Positives = 290/523 (55%), Gaps = 33/523 (6%) Query: 5 SQTPTIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISN 64 SQ P VL E G+ NI A + E ++ TLGP G D ++V ++N Sbjct: 2 SQQPG--VLPENMKRYMGRDAQRMNILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVVTN 59 Query: 65 DGATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHL 124 DG TIL+ + V HPAAK L+++++ Q+ EVGDGTT+ ++AGEL+++A+ L++ + + Sbjct: 60 DGVTILREMSVEHPAAKMLIEVAKTQEKEVGDGTTTAVVVAGELLRKAEELLDQNVHPTI 119 Query: 125 IMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVD 184 ++KGY+ A A E + +A ++ ++ +E+L + A T+++ K + ++ V+ Sbjct: 120 VVKGYQAAAQKAQELLKTIACEVGAQD---KEILTKIAMTSITGKGAEKAKEKLAEIIVE 176 Query: 185 AVLSL--DRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKIL 242 AV ++ D +D LI I+K G +++++ I GV K A Q PKK + KI Sbjct: 177 AVSAVVDDEGKVDKDLIKIEKKSGASIDDTELIKGVLVDKERVSA---QMPKKVTDAKIA 233 Query: 243 SLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDL 302 LN +E E E ++D A +++ +GAN++ + I DL Sbjct: 234 LLNCAIE--------ETASEMLKDMVA--------------EIKASGANVLFCQKGIDDL 271 Query: 303 ATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERY 362 A + A I A RV DM ++ +A G ++ + D+ + LG L EE +I + Sbjct: 272 AQHYLAKEGIVAARRVKKSDMEKLAKATGANVITNIKDLSAQDLGDAGLVEERKISGDSM 331 Query: 363 NLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSK 422 + C K T+L+RG E VI EV R++ DA+ +V +++ IV+GGG+TE+E+S Sbjct: 332 IFVEECKHPKAVTMLIRGTTEHVIEEVARAVDDAVGVVGCTIEDGRIVSGGGSTEVELSM 391 Query: 423 CLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAH-SKGEKWYGV 481 LR+Y++ I+G++Q+ + AFA ALEVIPR L ENAG DAIEIL K+R AH S G K G+ Sbjct: 392 KLREYAEGISGREQLAVRAFADALEVIPRTLAENAGLDAIEILVKVRAAHASNGNKCAGL 451 Query: 482 VFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETI 524 T + D V EP VK A+ SA E+T ++L +D+ I Sbjct: 452 NVFTGAVEDMCENGVVEPLRVKTQAIQSAAESTEMLLRIDDVI 494 >3AQ1-B nrPDB Length = 500 Score = 293 bits (749), Expect = 2e-79, Method: Compositional matrix adjust. Identities = 170/493 (34%), Positives = 281/493 (56%), Gaps = 14/493 (2%) Query: 52 LIVTSNQKTTISNDGATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKE 111 ++V S I+NDGATILK +D+ HPAAK +V++S+ QDAEVGDGTT+ +L+GEL+ + Sbjct: 1 MLVDSMGDIVITNDGATILKEMDIQHPAAKMIVEVSKTQDAEVGDGTTTAAVLSGELLSK 60 Query: 112 AKPFLEEGISSHLIMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLI 171 A+ + +G+ S +I +GYR A E + + + I+ + + L + A TA++ K Sbjct: 61 AEELIMKGVHSTIISEGYRHAAEKCREILETITIAISPDDEAA---LIKIAGTAITGKGA 117 Query: 172 HNNADFFVKMCVDAVLSLDRNDLDD------KLIGIKKIPGGAMEESLFINGVAFKKTFS 225 + + V AV S+ + D + I I+K GG++++S I+G+ K S Sbjct: 118 EAYKEKLSALTVKAVRSIVEEEEDGLKVNVLENIKIEKRAGGSIDDSELIDGLVIDKERS 177 Query: 226 YAGFEQQPKKFNNPKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQV 285 + P+K N KIL L+ +E + + ++E+++ Q +D E +++ E +V Sbjct: 178 HPNM---PEKVENAKILLLSCPVEFRKTEVDSEIKITSPGQMQLFLDQEEKMMREMAEKV 234 Query: 286 EETGANIVLSKLPIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEH 345 +GAN+V + I D+A + I+ RV D+ R+ + G +I I E Sbjct: 235 IASGANVVFCQKGIDDMAQYYIEKAGIYAVRRVKKSDLKRLSKVTGATIIQDLDQITTED 294 Query: 346 LGTCALFEEMQIGSERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQ 405 +GT L EE ++ + GC +K T+LL GG E V+ ++ +L+DA+ +V ++ Sbjct: 295 VGTAGLVEEKEVRGGKMTYVTGCQNSKAVTVLLHGGTEHVVDSLDHALNDALHVVGVVIE 354 Query: 406 NKLIVAGGGATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEIL 465 + +V GGG++E+E+S L +Y+ T+ G++Q+ ++ FA+ALEVIP L ENAG D I+I+ Sbjct: 355 DGKVVVGGGSSEVELSLRLSEYASTLKGREQLAVSKFAEALEVIPVALAENAGLDPIDIM 414 Query: 466 NKLRLAHSKGEKWYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETIT 525 +LR H KG K G+ T + D + V EP +K A+N+A EAT +IL +D+ + Sbjct: 415 VELRSQHEKGNKNAGLNVYTGEVVDMWENDVIEPLRIKTQAINAAMEATVMILRIDDVVA 474 Query: 526 NKGSESANAGMMP 538 +KG SAN GM P Sbjct: 475 SKG--SANQGMGP 485 >4B2T-G nrPDB Length = 545 Score = 292 bits (748), Expect = 2e-79, Method: Compositional matrix adjust. Identities = 174/544 (31%), Positives = 294/544 (54%), Gaps = 19/544 (3%) Query: 10 IVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATI 69 ++VL + T G+ NINA + + ++ LGP +++ ++NDG I Sbjct: 7 VLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAI 66 Query: 70 LKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGY 129 L+ + V HPAAK++++ISR QD EVGDGTTSV ILAGE++ A+ FLE+ + +++ Y Sbjct: 67 LREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAY 126 Query: 130 RKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSL 189 RKA+ + + ++++ + +S R+ + +++++K+I + + +DAV ++ Sbjct: 127 RKALDDMISTLKKISIPV---DTSNRDTMLNIINSSITTKVISRWSSLACNIALDAVKTV 183 Query: 190 D-----RNDLD-DKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILS 243 R ++D K ++KIPGG +E+S + GV K ++ + NP+I+ Sbjct: 184 QFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMR---RYIKNPRIVL 240 Query: 244 LNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLA 303 L+ LE K + ++ + ED+ I+ E + I + + + ++V+++ I DLA Sbjct: 241 LDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLA 300 Query: 304 TQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCA-LFEEMQIGSERY 362 + NI RV D NR+ +A G I S +++ E +GT A L E +IG E + Sbjct: 301 QHYLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREEDVGTGAGLLEIKKIGDEYF 360 Query: 363 NLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSK 422 C K CT+LLRG ++++++EVER+L DA+ + + L + +V GGGA+EM V+ Sbjct: 361 TFITECKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAH 420 Query: 423 CLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSK--GEKWYG 480 L + SK + G +Q A A+ALEVIPR L +N G I +L LR H++ E W G Sbjct: 421 ALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETW-G 479 Query: 481 VVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETIT---NKGSESANAGMM 537 V ET + D +WEP VK+ +A E L+L +D+ ++ KG + + G Sbjct: 480 VNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQSRQGGA 539 Query: 538 PPQG 541 P G Sbjct: 540 PDAG 543 >4B2T-A nrPDB Length = 556 Score = 287 bits (735), Expect = 7e-78, Method: Compositional matrix adjust. Identities = 183/527 (34%), Positives = 286/527 (54%), Gaps = 25/527 (4%) Query: 18 DASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVH 77 D S G+ N+ A ++ +K +LGP+G D ++V TI+NDGATILKLL+V H Sbjct: 10 DRSTGEAIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLLEVEH 69 Query: 78 PAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAV 137 PAAK L +++ QD EVGDGTTSV I+A EL+K A +++ I ++ GYR A AV Sbjct: 70 PAAKVLCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLACKEAV 129 Query: 138 EKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSLDRNDLDDK 197 I+E + T E GR+ L A+T+MSSK+I N DFF + VDAVL++ D+ + Sbjct: 130 RYISENLIINTDE--LGRDCLINAAKTSMSSKVIGINGDFFANLVVDAVLAIKYTDIRGQ 187 Query: 198 ------LIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELELK 251 I + K G + ES+ ING A G + PK+ N KI L+ L+ Sbjct: 188 PRYPVNSINVLKAHGRSQMESMLINGYALN---CVVGSQGMPKRIVNAKIACLDFSLQKT 244 Query: 252 AEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRN 311 K +V + E I E + E+++++ TGAN++L+ I D+ ++F + Sbjct: 245 KMKLGVQVVITDPEKLDQIRQRESDITKERIQKILATGANVILTTGGIDDMCLKYFVEAG 304 Query: 312 IFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEH------LGTCALFEEMQIGSERYNLF 365 RV D+ R+ +A G ++ ST ++++ E LG + +I + L Sbjct: 305 AMAVRRVLKRDLKRIAKASGATVLSTLANLEGEETFEASMLGQAEEVVQERICDDELILI 364 Query: 366 QGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLR 425 + + +++LRG + + E+ERSLHDA+ +VKR L++K +V GGGA E +S L Sbjct: 365 KNTKARTSASVILRGANDFMCDEMERSLHDALCVVKRVLESKSVVPGGGAVEAALSIYLE 424 Query: 426 DYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGE--------K 477 +Y+ ++ ++Q+ I FA++L VIP L NA D+ +++ KLR H++ + K Sbjct: 425 NYATSMGSREQLAIAEFARSLPVIPNTLAVNAAQDSTDLVAKLRAFHNEAQVNPERKNLK 484 Query: 478 WYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETI 524 W G+ DN V+EP +VK+ +L ATEA IL +D+ I Sbjct: 485 WIGLDLVNGKPRDNKQAGVFEPTIVKVKSLKFATEAAITILRIDDLI 531 >5GW5-g nrPDB Length = 534 Score = 275 bits (704), Expect = 3e-74, Method: Compositional matrix adjust. Identities = 165/538 (30%), Positives = 295/538 (54%), Gaps = 29/538 (5%) Query: 6 QTPTIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISND 65 Q P +V + + + G+ ISNI A AV + ++ LGP +++ ++ND Sbjct: 2 QAP-VVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND 60 Query: 66 GATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFL-EEGISSHL 124 G IL+ +DV HPAAK+++++SR QD EVGDGTT+V ILAGE++ + P+L E+ I + Sbjct: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 Query: 125 IMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVD 184 I++ +KA++ A+E I +++ + E + +++ + ++ +K + + ++ ++ +D Sbjct: 121 IIQALKKALTDALEVIKQVSKPVDVENDAA---MKKLIQASIGTKYVIHWSEKMCELALD 177 Query: 185 AVLSLDRNDLDD-------------KLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQ 231 AV ++ R DL + + ++KIPGG + +S + GV K + Sbjct: 178 AVKTV-RKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHPKMS- 235 Query: 232 QPKKFNNPKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAE---WQLIFEKLRQVEET 288 + NP+++ L+ LE K + + +E ED+ I+ E QL+ E++ V T Sbjct: 236 --RHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPT 293 Query: 289 GANIVLSKLPIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGT 348 +V+++ + DLA + RV D NR+ + G +I + D+K +GT Sbjct: 294 ---LVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGT 350 Query: 349 -CALFEEMQIGSERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNK 407 C LF+ IG E ++ C + K CT++LRGG++ ++ E++R+L DA+ + + + + Sbjct: 351 NCGLFKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSP 410 Query: 408 LIVAGGGATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNK 467 + GGGATEM VS L + +K + G QQ A A A+E IPR L +NAG D I +L++ Sbjct: 411 SLSPGGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQ 470 Query: 468 LRLAHSKGEKWYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETIT 525 LR H++G G+ + I D + +WEP ++K ++ +A E+ L+L VD+ ++ Sbjct: 471 LRAKHAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVS 528 >4V94-A nrPDB Length = 559 Score = 272 bits (695), Expect = 3e-73, Method: Compositional matrix adjust. Identities = 172/523 (32%), Positives = 284/523 (54%), Gaps = 31/523 (5%) Query: 29 NINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVHPAAKTLVDISR 88 N+ A +AV +K +LGP+G D ++V T++NDGATIL LLDV HPA K LV++++ Sbjct: 29 NVLATMAVANVVKSSLGPVGLDKMLVDDIGDFTVTNDGATILSLLDVQHPAGKILVELAQ 88 Query: 89 AQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAVEKINELAVDIT 148 QD E+GDGTTSV I+A EL+K A ++ I I+ G+R A+ A+ INE+ T Sbjct: 89 QQDREIGDGTTSVVIIASELLKRANELVKNKIHPTTIITGFRVALREAIRFINEVLS--T 146 Query: 149 SEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSLDRNDLDD------KLIGIK 202 S + G+E L A+T+MSSK+I ++DFF M VDA+L++ + K + + Sbjct: 147 SVDTLGKETLINIAKTSMSSKIIGADSDFFSNMVVDALLAVKTQNSKGEIKYPVKAVNVL 206 Query: 203 KIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKF--NNPKILSLNVELELKAEKDNAEVR 260 K G + ESL + G A T + + PK+ N KI L++ L+ ++ Sbjct: 207 KAHGKSATESLLVPGYALNCTVAS---QAMPKRIAGGNVKIACLDLNLQKARMAMGVQIN 263 Query: 261 VEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRVSA 320 ++ E + I E ++ E+++++ + GA +VL+ I DL + F + I R Sbjct: 264 IDDPEQLEQIRKREAGIVLERVKKIIDAGAQVVLTTKGIDDLCLKEFVEAKIMGVRRCKK 323 Query: 321 DDMNRVIQAVGGSIQSTTSDIKPE------HLGTCALFEEMQIGSERYNLFQGCPQAKTC 374 +D+ R+ +A G ++ S+ S+++ E +LG C + + + L +G + + Sbjct: 324 EDLRRIARATGATLVSSMSNLEGEETFESSYLGLCDEVVQAKFSDDECILIKGTSKHSSS 383 Query: 375 TLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYSKTIAGK 434 +++LRG + + E+ERSLHD++ +VKR L++ +V GGG E ++ L +++ T+ + Sbjct: 384 SIILRGANDYSLDEMERSLHDSLSVVKRTLESGNVVPGGGCVEAALNIYLDNFATTVGSR 443 Query: 435 QQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHS------------KGEKWYGVV 482 +Q+ I FA AL +IP+ L NA D+ E++ KLR H+ + + YG+ Sbjct: 444 EQLAIAEFAAALLIIPKTLAVNAAKDSSELVAKLRSYHAASQMAKPEDVKRRSYRNYGLD 503 Query: 483 FETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETIT 525 I D V EP + K+ +L SA EA IL +D IT Sbjct: 504 LIRGKIVDEIHAGVLEPTISKVKSLKSALEACVAILRIDTMIT 546 >4B2T-B nrPDB Length = 535 Score = 271 bits (693), Expect = 5e-73, Method: Compositional matrix adjust. Identities = 175/516 (33%), Positives = 285/516 (55%), Gaps = 8/516 (1%) Query: 12 VLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTT--ISNDGATI 69 + K G D + + +S+ +A+ + +K TLGP G D ++++S + + ++NDGATI Sbjct: 11 IFKAGADEERAETARLSSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGATI 70 Query: 70 LKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGY 129 LK + V +PAAK LVD+SR QD EVGDGTTSVT+LA EL++EA+ + + I I+ G+ Sbjct: 71 LKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIAGW 130 Query: 130 RKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSL 189 R+A A + + AVD S++ R+ L A T +SSKL+ ++ D F K+ V+AVL L Sbjct: 131 REATKAARQALLNSAVDHGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRL 190 Query: 190 DRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELE 249 + + + IKK+ GG++ +S G K QPK+ N KIL N ++ Sbjct: 191 KGSGNLEAIHVIKKL-GGSLADSYLDEGFLLDKKIGV----NQPKRIENAKILIANTGMD 245 Query: 250 L-KAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFFA 308 K + + VRV+ I AE + + EK+ ++ + G N +++ I + Q F Sbjct: 246 TDKIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFG 305 Query: 309 DRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNLFQGC 368 + + R+ GG I ST + LG+C L EE+ IG ++ F G Sbjct: 306 AAGVMAIEHADFVGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVMIGEDKLIHFSGV 365 Query: 369 PQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYS 428 + CT++LRG +Q++ E ERSLHDA+ ++ + +++ V GGG +EM ++ + + Sbjct: 366 ALGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDSRTVYGGGCSEMLMAHAVTQLA 425 Query: 429 KTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFETENI 488 GK+ + + ++AKAL ++P + +NAG+D+ +++ +LR AHS+G+ G+ + I Sbjct: 426 SRTPGKEAVAMESYAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGKTTAGLDMKEGTI 485 Query: 489 GDNFAKFVWEPALVKINALNSATEATNLILSVDETI 524 GD + E VK L SA EA +IL VD I Sbjct: 486 GDMSVLGITESFQVKRQVLLSAAEAAEVILRVDNII 521 >4V8R-AB nrPDB Length = 527 Score = 267 bits (682), Expect = 9e-72, Method: Compositional matrix adjust. Identities = 170/501 (33%), Positives = 276/501 (55%), Gaps = 8/501 (1%) Query: 27 ISNINACVAVQEALKPTLGPLGSDILIVTSNQKT-TISNDGATILKLLDVVHPAAKTLVD 85 +S +AV + +K TLGP G D L+ +++ T ++NDGATILK + + +PAAK LV+ Sbjct: 20 LSAFVGAIAVGDLVKSTLGPKGMDKLLQSASSNTCMVTNDGATILKSIPLDNPAAKVLVN 79 Query: 86 ISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEG-ISSHLIMKGYRKAVSLAVEKINELA 144 IS+ QD EVGDGTTSVT+L+ EL++EA+ +++ I I++GYR A + A++ + + A Sbjct: 80 ISKVQDDEVGDGTTSVTVLSAELLREAEKLIDQSKIHPQTIIEGYRLASAAALDALTKAA 139 Query: 145 VDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSLDRNDLDDKLIGIKKI 204 VD + +K+ RE L A+T +SSK++ + D F ++ +A+L L + + + I I KI Sbjct: 140 VDNSHDKTMFREDLIHIAKTTLSSKILSQDKDHFAELATNAILRL-KGSTNLEHIQIIKI 198 Query: 205 PGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELEL-KAEKDNAEVRVEH 263 GG + +S G K F QPK+ N KIL N L+ K + + +V+ Sbjct: 199 LGGKLSDSFLDEGFILAKKFG----NNQPKRIENAKILIANTTLDTDKVKIFGTKFKVDS 254 Query: 264 VEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRVSADDM 323 + AE + + K+ ++ + G N +++ I D Q F D I + + Sbjct: 255 TAKLAQLEKAEREKMKNKIAKISKFGINTFINRQLIYDYPEQLFTDLGINSIEHADFEGV 314 Query: 324 NRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNLFQGCPQAKTCTLLLRGGAE 383 R+ GG + ST + LG C + EE+ +G + + F GC + CT++LRG + Sbjct: 315 ERLALVTGGEVVSTFDEPSKCKLGECDVIEEIMLGEQPFLKFSGCKAGEACTIVLRGATD 374 Query: 384 QVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYSKTIAGKQQMIINAFA 443 Q + E ERSLHDA+ ++ + + V GGG EM +SK + ++ I GK+ + + AFA Sbjct: 375 QTLDEAERSLHDALSVLSQTTKETRTVLGGGCAEMVMSKAVDTEAQNIDGKKSLAVEAFA 434 Query: 444 KALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFETENIGDNFAKFVWEPALVK 503 +AL +P L +NAGFD+ E+++KLR + G G+ I D + E +K Sbjct: 435 RALRQLPTILADNAGFDSSELVSKLRSSIYNGISTSGLDLNNGTIADMRQLGIVESYKLK 494 Query: 504 INALNSATEATNLILSVDETI 524 ++SA+EA ++L VD I Sbjct: 495 RAVVSSASEAAEVLLRVDNII 515 >4B2T-D nrPDB Length = 542 Score = 267 bits (682), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 168/512 (32%), Positives = 281/512 (54%), Gaps = 20/512 (3%) Query: 28 SNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVHPAAKTLVDIS 87 SNI+A AV +A++ +LGP G D +I TI+NDGATILK + V+HPAA+ LV++S Sbjct: 39 SNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVELS 98 Query: 88 RAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAVEKINELAVDI 147 +AQD E GDGTTSV I+AG L+ L++GI +I + ++KA+ +E + +++ + Sbjct: 99 KAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGIEILTDMSRPV 158 Query: 148 TSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSL----DRNDLDDKLIGIKK 203 + S RE L A T+++SK++ + M VDAV+ + +D + I I K Sbjct: 159 ---ELSDRETLLNSAATSLNSKVVSQYSSLLSPMSVDAVMKVIDPATATSVDLRDIKIVK 215 Query: 204 IPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELEL-KAEKDNAEVRVE 262 GG +++ + G+ + + +G + K KI + L K + DN V + Sbjct: 216 KLGGTIDDCELVEGLVLTQKVANSGITRVEK----AKIGLIQFCLSAPKTDMDNQIVVSD 271 Query: 263 HVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPI-----GDLATQFFADRNIFCAGR 317 +V+ ++ E I ++Q+++TG N++L + I DLA F I Sbjct: 272 YVQ-MDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMVVKD 330 Query: 318 VSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQI-GSERYNLFQGCPQ-AKTCT 375 + +D+ + + +G + + LG+ L EE+ + GS + GC KT T Sbjct: 331 IEREDIEFICKTIGTKPVAHVDQFTADMLGSAELAEEVSLNGSGKLIKITGCASPGKTVT 390 Query: 376 LLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYSKTIAGKQ 435 +++RG + VI E ERS+HDA+ +++ ++ + ++AGGGA E+E++ L +YS+T++G + Sbjct: 391 IVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGME 450 Query: 436 QMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFETENIGDNFAKF 495 I AFA A+EVIP L ENAG + I + +LR H++GEK G+ I + + Sbjct: 451 SYCIRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTTGINVRKGGISNILEEL 510 Query: 496 VWEPALVKINALNSATEATNLILSVDETITNK 527 V +P LV ++AL ATE IL +D+ + + Sbjct: 511 VVQPLLVSVSALTLATETVRSILKIDDVVNTR 542 >5UYZ-A nrPDB Length = 541 Score = 258 bits (660), Expect = 3e-69, Method: Compositional matrix adjust. Identities = 157/501 (31%), Positives = 274/501 (54%), Gaps = 10/501 (1%) Query: 28 SNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVHPAAKTLVDIS 87 S+I A AV ++ +LGP G D ++V + T++NDGATIL ++DV H AK +V++S Sbjct: 36 SHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELS 95 Query: 88 RAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAVEKINELAVDI 147 ++QD E+GDGTT V +LAG L++EA+ L+ GI I GY +A +A+E++++++ + Sbjct: 96 KSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIERLDKISDSV 155 Query: 148 TSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLS---LDRNDLDDKLIGIKKI 204 + L++ A+T + SK++++ ++ V+AVL+ ++R D+D +LI ++ Sbjct: 156 LVDIKDTEPLIQ-TAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGK 214 Query: 205 PGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELELKAEKDNAEVRVEHV 264 GG +E++ I GV K FS+ Q PKK + KI L E K ++ V V Sbjct: 215 VGGRLEDTKLIKGVIVDKDFSHP---QMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSV 271 Query: 265 EDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRVSADDMN 324 EDY+A+ E + E ++Q++ETGAN+ + + D A N+ V ++ Sbjct: 272 EDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIE 331 Query: 325 RVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNLF--QGCPQAKTCTLLLRGGA 382 + A GG I S++ E LG L +E+ G+ + + + C ++ T+ +RGG Sbjct: 332 LIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGN 391 Query: 383 EQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYSKTIAGKQQMIINAF 442 + +I E +RSLHDA+ +++ +++ +V GGGA E+ + + + +Q + AF Sbjct: 392 KMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAF 451 Query: 443 AKALEVIPRQLCENAGFDAIEILNKLRLAHSKG-EKWYGVVFETENIGDNFAKFVWEPAL 501 A ALEVIP L EN+G + I+ + ++R K G+ + D + V E + Sbjct: 452 ADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLI 511 Query: 502 VKINALNSATEATNLILSVDE 522 K ++ AT+ +IL +D+ Sbjct: 512 GKKQQISLATQMVRMILKIDD 532 >4V8R-AG nrPDB Length = 590 Score = 250 bits (639), Expect = 9e-67, Method: Compositional matrix adjust. Identities = 167/594 (28%), Positives = 297/594 (50%), Gaps = 85/594 (14%) Query: 6 QTPTIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISND 65 Q P +V + + + G+ ISNI A AV + ++ LGP +++ ++ND Sbjct: 2 QAP-VVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND 60 Query: 66 GATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFL-EEGISSHL 124 G IL+ +DV HPAAK+++++SR QD EVGDGTT+V ILAGE++ + P+L E+ I + Sbjct: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 Query: 125 IMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVD 184 I++ +KA++ A+E I +++ + E + +++ + ++ +K + + ++ ++ +D Sbjct: 121 IIQALKKALTDALEVIKQVSKPVDVENDAA---MKKLIQASIGTKYVIHWSEKMCELALD 177 Query: 185 AVLSLDRNDLDD-------------KLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQ 231 AV ++ R DL + + ++KIPGG + +S + GV K + + Sbjct: 178 AVKTV-RKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHP---K 233 Query: 232 QPKKFNNPKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAE---WQLIFEKLRQVEET 288 + NP+++ L+ LE K + + +E ED+ I+ E QL+ E++ V T Sbjct: 234 MSRHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPT 293 Query: 289 GANIVLSKLPIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGT 348 +V+++ + DLA + RV D NR+ + G +I + D+K +GT Sbjct: 294 ---LVITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGT 350 Query: 349 -CALFEEMQIGSERYNLFQGC-----------PQ-------------------------- 370 C LF+ IG E ++ C PQ Sbjct: 351 NCGLFKVEMIGDEYFSFLDNCKEPGSGSGWSHPQFEKGSGKRRWKKNFIAVSAANRFKKI 410 Query: 371 -------------------AKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVA 411 K CT++LRGG++ ++ E++R+L DA+ + + + + + Sbjct: 411 SSSGALGSGHHHHHHHHGSGKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSP 470 Query: 412 GGGATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLA 471 GGGATEM VS L + +K + G QQ A A A+E IPR L +NAG D I +L++LR Sbjct: 471 GGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAK 530 Query: 472 HSKGEKWYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETIT 525 H++G G+ + I D + +WEP ++K ++ +A E+ L+L VD+ ++ Sbjct: 531 HAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVS 584 >4V8R-AE nrPDB Length = 562 Score = 244 bits (623), Expect = 8e-65, Method: Compositional matrix adjust. Identities = 166/538 (30%), Positives = 278/538 (51%), Gaps = 19/538 (3%) Query: 8 PTIVVLKEGTDASQ-GKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDG 66 P I+V +G Q G S+I A +V +K +LGP G D ++++ + + TI+NDG Sbjct: 28 PFIIVKDQGNKKRQHGLEAKKSHILAARSVASIIKTSLGPRGLDKILISPDGEITITNDG 87 Query: 67 ATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIM 126 ATIL +++ + AK LV +S++QD E+GDGTT V +LA L+ +A +++GI I Sbjct: 88 ATILSQMELDNEIAKLLVQLSKSQDDEIGDGTTGVVVLASALLDQALELIQKGIHPIKIA 147 Query: 127 KGYRKAVSLAVEKINELAVDIT-SEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDA 185 G+ +A LA+ K+ E DI+ S R+ L R A+T++ SK++ + D F +M V+A Sbjct: 148 NGFDEAAKLAISKLEETCDDISASNDELFRDFLLRAAKTSLGSKIVSKDHDRFAEMAVEA 207 Query: 186 VLSL---DRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKF------ 236 V+++ DR D+D LI ++ GG++ +S INGV K FS+ Q PK Sbjct: 208 VINVMDKDRKDVDFDLIKMQGRVGGSISDSKLINGVILDKDFSHP---QMPKCVLPKEGS 264 Query: 237 NNPKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSK 296 + K+ L E K ++ + VE+YQ + E E + V++ GA++V+ + Sbjct: 265 DGVKLAILTCPFEPPKPKTKHKLDISSVEEYQKLQTYEQDKFKEMIDDVKKAGADVVICQ 324 Query: 297 LPIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQ 356 D A ++ V ++ + + G I D+ + LGTC+ E + Sbjct: 325 WGFDDEANHLLLQNDLPAVRWVGGQELEHIAISTNGRIVPRFQDLSKDKLGTCSRIYEQE 384 Query: 357 IGS--ERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGG 414 G+ +R + + + KT T +RG + ++ E ER+LHD++ +V+ +++ +V GGG Sbjct: 385 FGTTKDRMLIIEQSKETKTVTCFVRGSNKMIVDEAERALHDSLCVVRNLVKDSRVVYGGG 444 Query: 415 ATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSK 474 A E+ +S + + + G Q FA+AL+ IP L EN+G D I L+ L+ K Sbjct: 445 AAEVTMSLAVSEEADKQRGIDQYAFRGFAQALDTIPMTLAENSGLDPIGTLSTLKSKQLK 504 Query: 475 GEKWYGVVFETENIGDNFAK--FVWEPALVKINALNSATEATNLILSVDETITNKGSE 530 EK + + G N K FV +P + K + AT+ +IL +D I + E Sbjct: 505 -EKISNIGVDCLGYGSNDMKELFVVDPFIGKKQQILLATQLCRMILKIDNVIISGKDE 561 >5GW4-d nrPDB Length = 528 Score = 227 bits (579), Expect = 8e-60, Method: Compositional matrix adjust. Identities = 162/512 (31%), Positives = 275/512 (53%), Gaps = 28/512 (5%) Query: 28 SNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVHPAAKTLVDIS 87 +NI A +V +A++ +LGP G D +I TS + ISNDG TILK + ++HP A+ LV++S Sbjct: 23 ANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPVARMLVEVS 82 Query: 88 RAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAVEKINELAVDI 147 AQD+E GDGTTSV IL G L+ A+ L +GI +I ++ A +V+ + E+ + Sbjct: 83 AAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDILLEMCHKV 142 Query: 148 TSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSL-DRN----DLDDKLIGIK 202 + S RE L R A T++SSK++ + F + VD+VL + D N DL+D I + Sbjct: 143 SL---SDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKNVDLND--IRLV 197 Query: 203 KIPGGAMEESLFINGVAFKKT-FSYAGFEQQPKKFNNPKILSLNVELELKAEKDNAEVRV 261 K GG ++++ I+GV +T AG P + KI ++ ++ K + E + Sbjct: 198 KKVGGTIDDTEMIDGVVLTQTAIKSAG---GPTRKEKAKIGL--IQFQISPPKPDTENNI 252 Query: 262 EHVEDYQ---AIVDAEWQLIFEKLRQVEETGANIVLSKLPI-----GDLATQFFADRNIF 313 V DY+ I+ E + +++++ N++L + I DLA F + NI Sbjct: 253 -IVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIM 311 Query: 314 CAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQI-GSE--RYNLFQGCPQ 370 + +++ + + +G + + LG+ L EE+ GS+ R + Sbjct: 312 VVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRNNNA 371 Query: 371 AKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYSKT 430 T ++++RG +I E ERSLHDA+ +++ ++ + ++AGGGA E+E+S+ L +++ Sbjct: 372 RPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARS 431 Query: 431 IAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFETENIGD 490 + G Q I FA ALEVIP L ENAG ++I+++ +LR H GE G+ + Sbjct: 432 MEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRSGTTN 491 Query: 491 NFAKFVWEPALVKINALNSATEATNLILSVDE 522 + + + +P LV +A+ A+E IL +D+ Sbjct: 492 TYEEHILQPVLVSTSAITLASECVKSILRIDD 523 >4B2T-Z nrPDB Length = 531 Score = 211 bits (538), Expect = 5e-55, Method: Compositional matrix adjust. Identities = 137/523 (26%), Positives = 262/523 (50%), Gaps = 18/523 (3%) Query: 13 LKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKL 72 L + ++ + + NI+A +Q+ L+ LGP G+ ++V+ ++ DG +L Sbjct: 7 LNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHE 66 Query: 73 LDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKA 132 + + HP A + ++ AQD GDGTTS ++ GEL+K+A ++ EG+ +I +G+ A Sbjct: 67 MQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAA 126 Query: 133 VSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSLDRN 192 A++ + ++ V K RE L ART++ +K+ AD + VD++L++ + Sbjct: 127 KEKALQFLEQVKV----SKEMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIKKQ 182 Query: 193 D--LDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELEL 250 D +D ++ I ++ + ++ I G+ + + K+ + IL+ NV LE Sbjct: 183 DEPIDLFMVEIMEMKHKSETDTSLIRGLVLDHGARHPDMK---KRVEDAYILTCNVSLEY 239 Query: 251 KAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANI---------VLSKLPIGD 301 + + N+ + E+ + +V AE + I ++++++ E + V+++ I Sbjct: 240 EKTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIIELKKKVCGDSDKGFVVINQKGIDP 299 Query: 302 LATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSER 361 + A I R +M R+ A GG ++ D+ P+ LG L E +G E+ Sbjct: 300 FSLDALAKEGIIALRRAKRRNMERLTLACGGIALNSLDDLNPDCLGHAGLVYEYTLGEEK 359 Query: 362 YNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVS 421 + + C ++ TLL++G + + +++ ++ D + VK A+ + +V G GA E+ ++ Sbjct: 360 FTFIEKCNNPRSVTLLIKGPNKHTLTQIKDAIRDGLRAVKNAIDDGCVVPGAGAVEVAMA 419 Query: 422 KCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGV 481 + L Y ++ G+ Q+ + AFA AL +IP+ L +N+GFD E L K++ HS+ + GV Sbjct: 420 EALVKYKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKVQAEHSESGQLVGV 479 Query: 482 VFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETI 524 T +W+ VK L+S T IL VDE + Sbjct: 480 DLNTGEPMVAAEAGIWDNYCVKKQLLHSCTVIATNILLVDEIM 522 >5GW5-q nrPDB Length = 568 Score = 197 bits (501), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 156/567 (27%), Positives = 274/567 (48%), Gaps = 38/567 (6%) Query: 6 QTPTIVVLKEGTDA-SQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISN 64 Q P + K+G ++ S GQII +I A + + ++GP G + +IV K I+N Sbjct: 7 QNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITN 66 Query: 65 DGATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHL 124 D AT+L+ LD+VHPA K LV + Q ++GDGT V ILAGEL+ ++ + G+S+ Sbjct: 67 DAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVE 126 Query: 125 IMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVD 184 I++GY A +++++E+ V ++K+ ELL + + +SSK + + D ++ + Sbjct: 127 IIQGYNMARKFTLKELDEMVVGEITDKNDKNELL-KMIKPVISSKK-YGSEDILSELVSE 184 Query: 185 AVLS----------LDRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPK 234 AV + ++D I + KI GG++ S I G+ F + G + Sbjct: 185 AVSHVLPVAQQAGEIPYFNVDS--IRVVKIMGGSLSNSTVIKGMVFNR--EPEGHVKSLS 240 Query: 235 KFNNPKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVL 294 + K+ L++ + V + + ++ E + I ++++ + G ++ Sbjct: 241 EDKKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIV 300 Query: 295 SKLPIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEE 354 + +G+LA + I S ++ R+ + G + PE LG + Sbjct: 301 AGAGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKT 360 Query: 355 MQIGSERYNLF---QGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNK--LI 409 M+IG +R +F QG ++T T++LRG + + ++ER++ D + VK ++ + Sbjct: 361 MEIGGDRVTVFKQEQG-EISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKL 419 Query: 410 VAGGGATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLR 469 + G GATE+E+ + Y + G Q+ I FA A EV+PR L E AG D E+L L Sbjct: 420 LPGAGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLY 479 Query: 470 LAHSKGEK--------WYGVVFETEN---IGDNFAKFVWEPALVKINALNSATEATNLIL 518 AH+ E + GV + E+ + D + +++ K A+N ATEA +L Sbjct: 480 AAHNVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVL 539 Query: 519 SVDETITNKGSESANAGMMPPQGAGRG 545 S+D+ I K + A PQG G Sbjct: 540 SIDQIIMAKKAGGPRA----PQGPRPG 562 >4B2T-Q nrPDB Length = 548 Score = 188 bits (478), Expect = 5e-48, Method: Compositional matrix adjust. Identities = 154/536 (28%), Positives = 257/536 (47%), Gaps = 17/536 (3%) Query: 12 VLKEGTDASQG-KGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATIL 70 +LKEG G + + NI AC + + + GP G + +++ +K ++ND ATIL Sbjct: 14 MLKEGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAATIL 73 Query: 71 KLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYR 130 + L+V HPAAK +V S Q+ EVGDGT V + AG L++ A+ L G+S +++GY Sbjct: 74 RELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRLGLSVSEVIEGYE 133 Query: 131 KAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSL- 189 A A E + +L E+ + MS + + N F K+ A +S+ Sbjct: 134 IACKKAHEILPDLVCCSAKNLRDVDEVSSLLHTSVMSKQ--YGNEVFLAKLIAQACVSIF 191 Query: 190 -DRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVEL 248 D + I + KI G + S ++G+ FKK E + KI + Sbjct: 192 PDSGHFNVDNIRVCKILGSGVHSSSVLHGMVFKKET-----EGDVTSVKDAKIAVYSCPF 246 Query: 249 ELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFFA 308 + + V ++ E+ E L+ +++ + +TGAN+V++ + D+A + Sbjct: 247 DGMITETKGTVLIKSAEELMNFSKGEENLMDAQVKAIADTGANVVVTGGRVADMALHYAN 306 Query: 309 DRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNLFQGC 368 NI S D+ R+ + VG + + E +G C ++G + +F+ Sbjct: 307 KYNIMLVRLNSKWDLRRLCKTVGATALPRLNPPVLEEMGHCDSVYLSEVGDTQVVVFKHE 366 Query: 369 PQ-AKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDY 427 + T++LRG + ++ ++ER++ D + K ++K +V GGGATE+E++K + Y Sbjct: 367 KEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQITSY 426 Query: 428 SKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFETE- 486 +T G +Q I FA+A E IPR L EN+G A E+++KL H +G K G+ E E Sbjct: 427 GETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGLDIEAEV 486 Query: 487 -NIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESANAGMMPPQG 541 + D V + L K A+ AT A +L VD+ I K + G PP G Sbjct: 487 PAVKDMLEAGVLDTYLGKYWAIKLATNAAVTVLRVDQIIMAKPA----GGPKPPSG 538 >5GW5-z nrPDB Length = 546 Score = 188 bits (477), Expect = 6e-48, Method: Compositional matrix adjust. Identities = 137/512 (26%), Positives = 254/512 (49%), Gaps = 26/512 (5%) Query: 29 NINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVHPAAKTLVDISR 88 N+ + +Q L+ LGP G+ ++V ++ DG +L + + P A + + Sbjct: 22 NVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQIQSPTAVLIARAAA 81 Query: 89 AQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAVEKINELAVDIT 148 AQD GDGTT+V L GEL+++A F++EG+ +I G+ A +++ ++E + T Sbjct: 82 AQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFKISKT 141 Query: 149 SEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSL---DRNDLDDKLIGIKKIP 205 + S+ RE L + AR+++ +K+ + + + DAVLS+ ++LD ++ I ++ Sbjct: 142 N-LSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADNLDLHMVEIMQMQ 200 Query: 206 GGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELELKAEKDNAEVRVEHVE 265 + +++ FI G+ + P + N +L LNV LE + + N+ + Sbjct: 201 HLSPKDTTFIKGLVLDHGGRHPDM---PTRVKNAYVLILNVSLEYEKTEVNSGFFYSSAD 257 Query: 266 DYQAIVDAEWQLIFEKLRQV-----EETGAN-----IVLSKLPIGDLATQFFADRNIFCA 315 + +E + + KL+++ E G + +++++ I ++ FA NI Sbjct: 258 QRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILAL 317 Query: 316 GRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNLFQGCPQAKTCT 375 R +M R+ GG Q++ D+ P+ LG L + IG E++ K+CT Sbjct: 318 RRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVTENTDPKSCT 377 Query: 376 LLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYSKT---IA 432 +L++G +A+ + ++ D + V L++K I+ G GA + +S+ LR + Sbjct: 378 ILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYIALSRYLRSANMNKLGAK 437 Query: 433 GKQQMIINAFAKALEVIPRQLCENAGFDAIEIL----NKLRLAHSKGEKWY-GVVFETEN 487 GK + I AFA+AL VIP+ L +N+GFD +++L ++L A E Y GV + Sbjct: 438 GKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDAQDSDETRYVGVDLNIGD 497 Query: 488 IGDNFAKFVWEPALVKINALNSATE-ATNLIL 518 D + +W+ V NA+ AT A+NL+L Sbjct: 498 SCDPTIEGIWDSYRVLRNAITGATGIASNLLL 529 >5X9V-A nrPDB Length = 521 Score = 152 bits (384), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 145/526 (27%), Positives = 248/526 (47%), Gaps = 45/526 (8%) Query: 26 IISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVHPAAKTLVD 85 + SN A A+ + + +LGP G D ++V + ++NDG TIL L+D HPAA+ +V+ Sbjct: 17 LFSNAAAVKALTQVVANSLGPKGLDAMLVDRFGEVVVTNDGVTILTLMDAQHPAARMVVN 76 Query: 86 ISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAVEKINELAV 145 ++RAQ+ EVGDGTT+ +LAG L+ E + +G+ ++ G +A++ A+ I + A+ Sbjct: 77 MARAQEREVGDGTTTAAVLAGALVSEGVNQILKGVPVSKVLAGMNRALNHALFLIRKNAI 136 Query: 146 DITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSLDRNDLDD---KLIGIK 202 + S R ++K+ + + DA L+ + L D KL + Sbjct: 137 KVGSITDD---------RLLAAAKIAGRGDERVAAILRDAAAMLE-DKLQDPGFKLADLV 186 Query: 203 KIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELELKAEKDNAEVRVE 262 GA ++ I GV K+ + E+ +K ++L L+ L + ++ A Sbjct: 187 LAKVGA--DTTLIPGVVINKSPLW---EEGSQKLQEVRLLVLDDGLYPEEVEEEALASEA 241 Query: 263 HVEDYQAIVDAEWQLIF-EKLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRVSAD 321 E Y + Q IF E L++++E G ++L I D+A +F + I R++ Sbjct: 242 GFEQY-----LKNQKIFQENLKKLKELGVKLILLTRGISDIAEEFCYENEIMVITRITQK 296 Query: 322 DMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQ--IGSER---------YNLFQGCPQ 370 ++ RV++ G TS KP EE+Q +G R + + +G Sbjct: 297 ELKRVLEFTGARAAKRTSLNKP--------VEELQKMLGYARTCFYDSRLDFTIIEGGAG 348 Query: 371 AKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYSKT 430 T T+L+ ++V+ E ER DA A ++ ++ GGGA + +S+ + Sbjct: 349 KATATVLIGAATDEVVDEQERIAKDAAGSFAAAYRSG-VLPGGGAFFLYLSREVESLKNR 407 Query: 431 IAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKL-RLAHSKGEKWYGVVFETENIG 489 + G + + AF++AL+V R + ENAGF+ +E L L L K G+ FET Sbjct: 408 LPGMESYGVMAFSEALKVPFRVMAENAGFNGLEKLGDLMTLQVQKNNYALGLDFETGEFI 467 Query: 490 DNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESANAG 535 D A V +PA V A+ +A+E +L ++ I K E G Sbjct: 468 DMIAGGVVDPAEVVYQAVKNASEVAISLLKINTIIKMKDYEVLKEG 513 >1GN1-A nrPDB Length = 178 Score = 84.0 bits (206), Expect = 2e-16, Method: Composition-based stats. Identities = 50/175 (28%), Positives = 86/175 (49%), Gaps = 4/175 (2%) Query: 209 MEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELELKAEKDNAEVRVEHVEDYQ 268 ME+S + GV K ++ + K NP+I+ L+ LE K + ++ + ED+ Sbjct: 1 MEDSCVLRGVMINKDVTHPRMRRYIK---NPRIVLLDSSLEYKKGESQTDIEITREEDFT 57 Query: 269 AIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRVSADDMNRVIQ 328 I+ E + I + + + ++V+++ I DLA + N+ RV D NR+ + Sbjct: 58 RILQMEEEYIHQLCEDIIQLKPDVVITEKGISDLAQHYLMRANVTAIRRVRKTDNNRIAR 117 Query: 329 AVGGSIQSTTSDIKPEHLGTCA-LFEEMQIGSERYNLFQGCPQAKTCTLLLRGGA 382 A G I S +++ + +GT A L E +IG E + C K CT+LLRG + Sbjct: 118 ACGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGAS 172 >4V4O-A nrPDB Length = 543 Score = 82.0 bits (201), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 135/558 (24%), Positives = 228/558 (40%), Gaps = 86/558 (15%) Query: 35 AVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVV----HPAAKTLVDISRAQ 90 AV A+K TLGP G ++++ TI+ DG T+ K +++ + A+ L +++ Sbjct: 21 AVANAVKVTLGPRGRNVVLEKKFGSPTITKDGVTVAKEVELEDHLENIGAQLLKEVASKT 80 Query: 91 DAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAVEKINELAVDITSE 150 + GDGTT+ T+LA +++E + G + + +G KAV AVEKI LA+ + Sbjct: 81 NDVAGDGTTTATVLAQAIVREGLKNVAAGANPLALKRGIEKAVEAAVEKIKALAIPVEDR 140 Query: 151 KSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSLDRNDLDDKLIGIKKIPGGAME 210 K+ E+ A KLI AD K+ + +++++ + ++E Sbjct: 141 KAI-EEVATISANDPEVGKLI---ADAMEKVGKEGIITVEESK--------------SLE 182 Query: 211 ESL-FINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVE--LELKAEKDNAEVR-----VE 262 L F+ G F K + P NP+ + +E L EK + VR +E Sbjct: 183 TELKFVEGYQFDKGYI------SPYFVTNPETMEAVLEDAFILIVEKKVSNVRELLPILE 236 Query: 263 HV-----------EDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLP-IGDLATQFFADR 310 V ED + +A L+ KLR ++ K P GD + D Sbjct: 237 QVAQTGKPLLIIAEDVEG--EALATLVVNKLRGT----LSVAAVKAPGFGDRRKEMLKDI 290 Query: 311 NIFCAGRVSADDMN-----------------RVIQ----AVGGSIQSTTSDIKPEHLGTC 349 G V ++++ R+ + VGG + DI+ G Sbjct: 291 AAVTGGTVISEELGFKLENATLSMLGRAERVRITKDETTIVGG--KGKKEDIEARINGIK 348 Query: 350 ALFEEMQIGSERYNLFQGCPQAKTCTLLLRGGA--EQVIAEVERSLHDAIMIVKRALQNK 407 E R L + + ++R GA E + E + DA+ + A++ Sbjct: 349 KELETTDSEYAREKLQERLAKLAGGVAVIRVGAATETELKEKKHRFEDALNATRAAVEEG 408 Query: 408 LIVAGGGATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNK 467 IV GGG T + + + K + G + +ALE RQ+ ENAG++ I+ + Sbjct: 409 -IVPGGGVTLLRAISAVEELIKKLEGDEATGAKIVRRALEEPARQIAENAGYEGSVIVQQ 467 Query: 468 LRLAHSKGEKWYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNK 527 + LA +K + YG T D + +PA V +AL +A LIL+ + + K Sbjct: 468 I-LAETKNPR-YGFNAATGEFVDMVEAGIVDPAKVTRSALQNAASIGALILTTEAVVAEK 525 Query: 528 GSESANAGMMPPQGAGRG 545 + + P AG G Sbjct: 526 PEKKEST----PASAGAG 539 >1IOK-A nrPDB Length = 545 Score = 75.1 bits (183), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 129/563 (22%), Positives = 231/563 (41%), Gaps = 88/563 (15%) Query: 20 SQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVHP- 78 S + +++ +N +A+K TLGP G +++I S I+ DG ++ K +++ Sbjct: 10 SDARDRMLKGVNILA---DAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEIELSDKF 66 Query: 79 ---AAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSL 135 A+ + +++ + E GDGTT+ T+LA +++E + G++ + +G A + Sbjct: 67 ENMGAQMVREVASRTNDEAGDGTTTATVLAQAIVREGLKAVAAGMNPMDLKRGIDVATAK 126 Query: 136 AVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSLDRNDLD 195 VE I KS+ R + + + A + N F + +A+ + + Sbjct: 127 VVEAI----------KSAARPVND-SSEVAQVGTISANGESFIGQQIAEAMQRVG----N 171 Query: 196 DKLIGIKKIPGGAME-ESLFINGVAFKKTFSYAGFEQQPKK-----------FNNPKILS 243 + +I +++ G ME E + G+ F + + F K + K+ S Sbjct: 172 EGVITVEENKG--METEVEVVEGMQFDRGYLSPYFVTNADKMIAELEDAYILLHEKKLSS 229 Query: 244 LN-----VELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLP 298 L +E ++++K V ED + +A L+ KLR G I K P Sbjct: 230 LQPMVPLLESVIQSQKPLLIV----AEDVEG--EALATLVVNKLR----GGLKIAAVKAP 279 Query: 299 -IGDLATQFFADRNIFCAGRVSADDM-----NRVIQAVG--------------------- 331 GD D I G+V ++D+ N I +G Sbjct: 280 GFGDRRKAMLQDIAILTGGQVISEDLGMKLENVTIDMLGRAKKVSINKDNTTIVDGAGEK 339 Query: 332 GSIQSTTSDIKPEHLGTCALFEEMQIGSERYNLFQGCPQAKTCTLLLRGGAEQVIAEVER 391 I++ S I+ + T + ++ ++ ER G + + G E + E + Sbjct: 340 AEIEARVSQIRQQIEETTSDYDREKL-QERVAKLAGG----VAVIRVGGMTEIEVKERKD 394 Query: 392 SLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPR 451 + DA+ + A+Q ++V GGG ++ +K L S + Q I +ALE R Sbjct: 395 RVDDALNATRAAVQEGIVV-GGGVALVQGAKVLEGLSGANS-DQDAGIAIIRRALEAPMR 452 Query: 452 QLCENAGFDAIEILNKLRLAHSKGEKWYGVVFETENIGDNFAKFVWEPALVKINALNSAT 511 Q+ ENAG D + K+R +K +G +TE GD F V +PA V AL A Sbjct: 453 QIAENAGVDGAVVAGKVR---ESSDKAFGFNAQTEEYGDMFKFGVIDPAKVVRTALEDAA 509 Query: 512 EATNLILSVDETITNKGSESANA 534 L+++ + I K A A Sbjct: 510 SVAGLLITTEAMIAEKPEPKAPA 532 >1ASS-A nrPDB Length = 159 Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 39/138 (28%), Positives = 68/138 (49%) Query: 231 QQPKKFNNPKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGA 290 + P N KI ++ LE+K + A+V++ Q ++ E + + +++++GA Sbjct: 14 KMPDVVKNAKIALIDSALEIKKTEIEAKVQISDPSKIQDFLNQETNTFKQMVEKIKKSGA 73 Query: 291 NIVLSKLPIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCA 350 N+VL + I D+A + A I+ RV DM ++ +A G I + D+ P LG Sbjct: 74 NVVLCQKGIDDVAQHYLAKEGIYAVRRVKKSDMEKLAKATGAKIVTDLDDLTPSVLGEAE 133 Query: 351 LFEEMQIGSERYNLFQGC 368 EE +IG +R GC Sbjct: 134 TVEERKIGDDRMTFVMGC 151 >1E0R-B nrPDB Length = 159 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 41/154 (26%), Positives = 76/154 (49%), Gaps = 3/154 (1%) Query: 215 INGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAE 274 +NG+ K + G P + KI L+ LE+K + + +R+E Q + E Sbjct: 1 MNGIIVDKEKVHPGM---PDVVKDAKIALLDAPLEIKKPEFDTNLRIEDPSMIQKFLAQE 57 Query: 275 WQLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSI 334 ++ E + +++ GAN+V+++ I D+A + + I+ RV DM+++ +A G SI Sbjct: 58 ENMLREMVDKIKSVGANVVITQKGIDDMAQHYLSRAGIYAVRRVKKSDMDKLAKATGASI 117 Query: 335 QSTTSDIKPEHLGTCALFEEMQIGSERYNLFQGC 368 ST +I LGT E++++G + G Sbjct: 118 VSTIDEISSSDLGTAERVEQVKVGEDYMTFVTGS 151 >4AAR-A nrPDB Length = 548 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 39/120 (32%), Positives = 67/120 (55%), Gaps = 6/120 (5%) Query: 38 EALKPTLGPLGSDILIVTSNQKTTISNDGATI---LKLLDVVHPAAKTLVD--ISRAQDA 92 +A+K TLGP G ++++ S TI+ DG ++ ++L D +V S+A DA Sbjct: 25 DAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASKANDA 84 Query: 93 EVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAVEKINELAVDITSEKS 152 GDGTT+ T+LA ++ E + G++ + +G KAV+ AVE++ L+V + K+ Sbjct: 85 -AGDGTTTATVLAQAIITEGLKAVAAGMNPMDLKRGIDKAVTAAVEELKALSVPCSDSKA 143 Score = 38.1 bits (87), Expect = 0.009, Method: Compositional matrix adjust. Identities = 37/140 (26%), Positives = 62/140 (44%), Gaps = 10/140 (7%) Query: 387 AEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYSKTIAGKQQMIINAFAKAL 446 A VE +LH RA + +VAGGG + V+ L D + Q + I +A+ Sbjct: 394 ARVEAALH-----ATRAAVEEGVVAGGGVALIRVASKLADL-RGQNEDQNVGIKVALRAM 447 Query: 447 EVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFETENIGDNFAKFVWEPALVKINA 506 E RQ+ N G + + N ++ G+ YG TE G+ + +P V +A Sbjct: 448 EAPLRQIVLNCGEEPSVVANTVK----GGDGNYGYNAATEEYGNMIDMGILDPTKVTRSA 503 Query: 507 LNSATEATNLILSVDETITN 526 L A L+++ + +T+ Sbjct: 504 LQYAASVAGLMITTECMVTD 523 >1SJP-A nrPDB Length = 504 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 112/514 (21%), Positives = 210/514 (40%), Gaps = 86/514 (16%) Query: 61 TISNDGATILKLLDVVHP----AAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFL 116 TI+NDG +I K +++ P A+ + ++++ D GDGTT+ T+LA L++E + Sbjct: 5 TITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNV 64 Query: 117 EEGISSHLIMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNAD 176 G + G ++ + AVEK+ E + E + ++ A +A + A+ Sbjct: 65 AAGANPL----GLKRGIEKAVEKVTETLLKGAKEVETKEQIAATAAISAGDQSIGDLIAE 120 Query: 177 FFVKMCVDAVLSLDRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKK- 235 K+ + V++++ ++ G++ +E G+ F K + F P++ Sbjct: 121 AMDKVGNEGVITVEESN----TFGLQ------LE---LTEGMRFDKGYISGYFVTDPERQ 167 Query: 236 ---FNNPKILSLNVELELKAEKDNAEVRVEHV-----------EDYQAIVDAEWQLIFEK 281 +P IL V ++ KD + +E V ED + +A L+ K Sbjct: 168 EAVLEDPYILL--VSSKVSTVKDLLPL-LEKVIGAGKPLLIIAEDVEG--EALSTLVVNK 222 Query: 282 LRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRV----------SAD---------- 321 +R T ++ + GD D I G+V +AD Sbjct: 223 IRG---TFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISEEVGLTLENADLSLLGKARKV 279 Query: 322 ----DMNRVIQAVGGS--IQSTTSDIKPEHLGTCALFEEMQIGSERYNLFQGCPQAKTCT 375 D +++ G + I + I+ E + + ++ ++ ER G Sbjct: 280 VVTKDETTIVEGAGDTDAIAGRVAQIRQEIENSDSDYDREKL-QERLAKLAGG-----VA 333 Query: 376 LLLRGGAEQV-IAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYSKTIAGK 434 ++ G A +V + E + + DA+ K A++ IVAGGG T ++ + L + + G Sbjct: 334 VIKAGAATEVELKERKHRIEDAVRNAKAAVEEG-IVAGGGVTLLQAAPTLDELK--LEGD 390 Query: 435 QQMIINAFAKALEVIPRQLCENAGFDAIEILNKLR-LAHSKGEKWYGVVFETENIGDNFA 493 + N ALE +Q+ N+G + + K+R L G V+E D A Sbjct: 391 EATGANIVKVALEAPLKQIAFNSGLEPGVVAEKVRNLPAGHGLNAQTGVYE-----DLLA 445 Query: 494 KFVWEPALVKINALNSATEATNLILSVDETITNK 527 V +P V +AL +A L L+ + + +K Sbjct: 446 AGVADPVKVTRSALQNAASIAGLFLTTEAVVADK 479 >5DA8-A nrPDB Length = 545 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 33/117 (28%), Positives = 60/117 (51%), Gaps = 4/117 (3%) Query: 39 ALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVHP----AAKTLVDISRAQDAEV 94 A+K TLGP G ++LI T + DG T+ K +++V P A+ + +++ Sbjct: 26 AVKVTLGPAGRNVLIDKKFGAPTSTKDGVTVAKEIELVDPVENMGAQMVREVASKTSDVA 85 Query: 95 GDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAVEKINELAVDITSEK 151 GDGTT+ T+LA + +E + G + +G +AV V ++ ++ I+ +K Sbjct: 86 GDGTTTATVLAQAIYREGLKNVTAGARPIDLKRGIDRAVKEVVAELRNISRSISGKK 142 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 56/228 (24%), Positives = 94/228 (41%), Gaps = 27/228 (11%) Query: 309 DRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNLFQGC 368 D G+ +++ I + G I+ +TSD E L ER G Sbjct: 328 DNTTIVEGKGKQEEIKARINEIKGQIEKSTSDYDTEKL------------QERLAKLSGG 375 Query: 369 PQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYS 428 L + E + E + + DA+ + A+Q ++V GGG + +K L + Sbjct: 376 ----VAVLKIGASTEVEMKEKKARVEDALHATRAAVQEGIVV-GGGVALIRAAKGL---A 427 Query: 429 KTIAGK--QQMIINAFAKALEVIPRQLCENAG-FDAIEILNKLRLAHSKGEKWYGVVFET 485 K +A Q+ I +ALE RQ+ N G D +L K++ A E YG T Sbjct: 428 KAVADNEDQKTGIEIIRRALEEPLRQIVANTGTTDGAVVLEKVKNA----EGDYGFNART 483 Query: 486 ENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESAN 533 E + V +P V +AL +A +++L+ + IT+ + A+ Sbjct: 484 EQYENLIEAGVVDPTKVTRSALENAASVASILLTTEAAITDVKEDKAD 531 >4PJ1-A nrPDB Length = 558 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 32/116 (27%), Positives = 60/116 (51%), Gaps = 4/116 (3%) Query: 38 EALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVHP----AAKTLVDISRAQDAE 93 +A+ T+GP G ++I S ++ DG T+ K +D+ AK + D++ + E Sbjct: 51 DAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEE 110 Query: 94 VGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAVEKINELAVDITS 149 GDGTT+ T+LA + KE + +G + I +G AV + ++ + + +T+ Sbjct: 111 AGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTT 166 >5CDI-A nrPDB Length = 552 Score = 42.0 bits (97), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 108/530 (20%), Positives = 214/530 (40%), Gaps = 80/530 (15%) Query: 43 TLGPLGSDILIVTSNQKTTISNDGATI---LKLLDVVHPAAKTLVDISRAQ-DAEVGDGT 98 T+GP G ++++ + I NDG TI ++L D V TLV + A+ + GDGT Sbjct: 31 TIGPKGRNVVLESKFGAPKIVNDGVTIAREVELSDPVENIGATLVRQAAARTNDTAGDGT 90 Query: 99 TSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAVEKINELAVDITSEKSSGRELL 158 T+ T+L+ + E + G + +++G K V V+++ ++ Sbjct: 91 TTATVLSAAFIAEGMKIVSAGTNPVQLVRGMEKTVQELVKELRKM--------------- 135 Query: 159 ERCARTAMSSKLIHNNADFFVKMCVDAVLSLDRNDL-DDKLIGIKKIPGGAMEES----- 212 S ++ + D CV A + D L D + + + MEE Sbjct: 136 ---------SSVVQTDKDLANVACVSAGGNTDIGSLISDAMAKVGRTGVVTMEEGKTAED 186 Query: 213 --LFINGVAFKKTFSYAGFEQQPKK----FNNPKILSLNVELELKAEKDNAEVRVEHVE- 265 +F+ G+ F++ ++ F P++ + N KIL V+ ++ +D + + Sbjct: 187 QLVFVEGMQFERGYTSPYFVTDPERMICEYENCKILL--VDKKISTARDIITILESAIRG 244 Query: 266 DYQAIVDAE-------WQLIFEKLRQVEETGANIVLSKLP-IGDLATQFFADRNIFCAGR 317 +Y ++ AE L+ KLR +V K P G+ + + D I G Sbjct: 245 NYPLLIMAEEVEQEALATLVVNKLRGT----LKVVAIKAPGFGERRSSYLEDIAILTGGT 300 Query: 318 VSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFE-----------------EMQIGS- 359 V D+M ++ ++ T + I T + + +MQ Sbjct: 301 VVRDEMGVSLEQATDAVLGTAAKITITKERTTVVGDGSTAADVAARVKQIRNLQMQTDQD 360 Query: 360 -ERYNLFQGCPQAKTCTLLLRGGA--EQVIAEVERSLHDAIMIVKRALQNKLIVAGGGAT 416 ER L + + +++ GA E + E + + DA+ + A++ +V GGG T Sbjct: 361 YEREKLQERIARLSGGVAIIQVGAQTETELKEKKLRVEDALNATRAAVEEG-VVPGGGCT 419 Query: 417 EMEVSKCLRDYSKTIAG-KQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKG 475 + +S+ + + + +QQM + +AL + + +NAG + ++N+ + + Sbjct: 420 LLRLSEKVDVIKRRMTDPEQQMGADIIKRALCYPIKLIAQNAGVNGSVVMNE--VMKNLD 477 Query: 476 EKWYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETIT 525 YG T++ + + +P+ V ++ +A L D +T Sbjct: 478 RPHYGYNAATDSFENLMETGIIDPSKVVRCSMENAVSVAKTFLLADVVVT 527 >5DA0-A nrPDB Length = 505 Score = 30.0 bits (66), Expect = 2.7, Method: Compositional matrix adjust. Identities = 22/72 (30%), Positives = 33/72 (45%), Gaps = 10/72 (13%) Query: 69 ILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKG 128 L D HPA + ++D+S DA DG+ G L K F+ +G S L +G Sbjct: 423 FLHQFDFTHPARRVVIDLS---DAHFWDGSA-----VGALDKVMLKFMRQGTSVEL--RG 472 Query: 129 YRKAVSLAVEKI 140 A + VE++ Sbjct: 473 LNAASATLVERL 484 >3NO5-A nrPDB Length = 275 Score = 29.6 bits (65), Expect = 3.9, Method: Compositional matrix adjust. Identities = 19/56 (33%), Positives = 28/56 (50%), Gaps = 3/56 (5%) Query: 236 FNNPKILSLNVELELKAEKDNAEVRV---EHVEDYQAIVDAEWQLIFEKLRQVEET 288 N P I+S+ + L +KDN V + E VE QA +A L+ +R +ET Sbjct: 2 MNKPCIISVAITGSLPRKKDNPAVPITVSEQVESTQAAFEAGATLVHLHVRNDDET 57 >2AWD-A nrPDB Length = 323 Score = 28.9 bits (63), Expect = 6.7, Method: Compositional matrix adjust. Identities = 29/125 (23%), Positives = 56/125 (44%), Gaps = 20/125 (16%) Query: 384 QVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYSKTIAGKQQMIINAFA 443 Q ++ D+I I+ Q +++ AG + E+S L ++ + I KQ I+ Sbjct: 80 QAFTSIKEETRDSIAILHEGNQTEILEAGPTVSPEEISNFLENFDQLI--KQAEIVTISG 137 Query: 444 KALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFETENIGDNFAKFV---WEPA 500 + +P + E++ K AH++ K V+ +T GD+ + + W+P Sbjct: 138 SLAKGLPSDFYQ-------ELVQK---AHAQEVK---VLLDTS--GDSLRQVLQGPWKPY 182 Query: 501 LVKIN 505 L+K N Sbjct: 183 LIKPN 187 >3H1T-A nrPDB Length = 590 Score = 28.5 bits (62), Expect = 8.0, Method: Compositional matrix adjust. Identities = 30/112 (26%), Positives = 47/112 (41%), Gaps = 15/112 (13%) Query: 304 TQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYN 363 T FA +FC + AD+M R + ++ S S P+++ EE +IG + Sbjct: 436 TDRFAKTIVFCVDQEHADEMRRAL----NNLNSDLSRKHPDYVARVTS-EEGKIGKGHLS 490 Query: 364 LFQ----GCPQAKTCTLLLRGGAEQ------VIAEVERSLHDAIMIVKRALQ 405 FQ P T + LL G + V+A V S+ + IV R + Sbjct: 491 RFQELETSTPVILTTSQLLTTGVDAPTCKNVVLARVVNSMSEFKQIVGRGTR 542 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5GW4-h nrPDB 662 0.0 4B2T-H nrPDB 590 e-169 1Q3S-A nrPDB 577 e-165 4XCG-B nrPDB 574 e-164 1A6E-A nrPDB 572 e-163 3J1C-A nrPDB 570 e-163 3J1E-A nrPDB 568 e-162 4XCI-A nrPDB 567 e-162 1A6D-B nrPDB 563 e-161 3RUW-A nrPDB 562 e-160 4B2T-G nrPDB 559 e-159 5UYZ-A nrPDB 546 e-155 4V8R-AE nrPDB 545 e-155 3IYF-A nrPDB 533 e-152 5GW5-g nrPDB 525 e-149 3AQ1-B nrPDB 520 e-148 4B2T-D nrPDB 517 e-147 4B2T-A nrPDB 516 e-147 4V8R-AG nrPDB 495 e-140 4V94-A nrPDB 494 e-140 4B2T-B nrPDB 492 e-139 4B2T-Z nrPDB 492 e-139 4V8R-AB nrPDB 491 e-139 4B2T-Q nrPDB 483 e-137 5GW4-d nrPDB 473 e-133 5GW5-q nrPDB 469 e-132 5GW5-z nrPDB 459 e-129 5X9V-A nrPDB 392 e-109 4V4O-A nrPDB 319 2e-87 1IOK-A nrPDB 310 7e-85 5CDI-A nrPDB 289 2e-78 5DA8-A nrPDB 273 1e-73 1SJP-A nrPDB 273 1e-73 4AAR-A nrPDB 271 5e-73 4PJ1-A nrPDB 254 7e-68 1GN1-A nrPDB 179 2e-45 1E0R-B nrPDB 166 3e-41 1ASS-A nrPDB 161 6e-40 Sequences not found previously or not previously below threshold: 5CDK-A nrPDB 68 8e-12 3OSX-A nrPDB 55 6e-08 1KID-A nrPDB 53 4e-07 1SRV-A nrPDB 53 4e-07 1DKD-A nrPDB 49 5e-06 3M6C-A nrPDB 46 3e-05 3LXD-A nrPDB 44 1e-04 5CDJ-A nrPDB 43 4e-04 3E0V-A nrPDB 35 0.097 5LY3-A nrPDB 30 2.4 2GJN-A nrPDB 30 2.9 1Q1R-A nrPDB 30 3.1 4KRZ-A nrPDB 30 3.4 3OZB-A nrPDB 30 3.9 5NLM-A nrPDB 30 4.0 2W96-B nrPDB 29 5.5 4XFK-A nrPDB 29 5.8 3OZ2-A nrPDB 29 6.1 >5GW4-h nrPDB Length = 550 Score = 662 bits (1709), Expect = 0.0, Method: Composition-based stats. Identities = 550/550 (100%), Positives = 550/550 (100%) Query: 1 MNFGSQTPTIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKT 60 MNFGSQTPTIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKT Sbjct: 1 MNFGSQTPTIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKT 60 Query: 61 TISNDGATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGI 120 TISNDGATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGI Sbjct: 61 TISNDGATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGI 120 Query: 121 SSHLIMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVK 180 SSHLIMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVK Sbjct: 121 SSHLIMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVK 180 Query: 181 MCVDAVLSLDRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPK 240 MCVDAVLSLDRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPK Sbjct: 181 MCVDAVLSLDRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPK 240 Query: 241 ILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIG 300 ILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIG Sbjct: 241 ILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIG 300 Query: 301 DLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSE 360 DLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSE Sbjct: 301 DLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSE 360 Query: 361 RYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEV 420 RYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEV Sbjct: 361 RYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEV 420 Query: 421 SKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYG 480 SKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYG Sbjct: 421 SKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYG 480 Query: 481 VVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESANAGMMPPQ 540 VVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESANAGMMPPQ Sbjct: 481 VVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESANAGMMPPQ 540 Query: 541 GAGRGRGMPM 550 GAGRGRGMPM Sbjct: 541 GAGRGRGMPM 550 >4B2T-H nrPDB Length = 543 Score = 590 bits (1521), Expect = e-169, Method: Composition-based stats. Identities = 334/521 (64%), Positives = 416/521 (79%), Gaps = 2/521 (0%) Query: 10 IVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATI 69 +++LKEGTD+SQG Q++SNI+AC + EA++ TLGP G D LIV K TISNDGATI Sbjct: 6 VILLKEGTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATI 65 Query: 70 LKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGY 129 LKLLDVVHPAAKTLVDI+++QDAEVGDGTTSVT+LA E +K+ KP++EEG+ +I++ + Sbjct: 66 LKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAF 125 Query: 130 RKAVSLAVEKINELAVDITS-EKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLS 188 R A LAV KI E+AV + +K R+LLE+CA TA+SSKLI FF KM VDAV+ Sbjct: 126 RTATQLAVNKIKEIAVTVKKEDKVEQRKLLEKCAMTALSSKLISQQKAFFAKMVVDAVMM 185 Query: 189 LDRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVEL 248 LD + L K+IGIKK+ GGA+EES + GVAFKKTFSYAGFE QPKK++NP I LNVEL Sbjct: 186 LD-DLLQLKMIGIKKVQGGALEESQLVAGVAFKKTFSYAGFEMQPKKYHNPMIALLNVEL 244 Query: 249 ELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFFA 308 ELKAEKDNAE+RV VEDYQAIVDAEW ++++KL ++ +GA +VLSKLPIGD+ATQ+FA Sbjct: 245 ELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHHSGAKVVLSKLPIGDVATQYFA 304 Query: 309 DRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNLFQGC 368 DR++FCAGRV +D+ R + A GGSIQ++ + + + LG C +FEE QIG ERYN F GC Sbjct: 305 DRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALSSDVLGRCQVFEETQIGGERYNFFTGC 364 Query: 369 PQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYS 428 P+AKTCT++LRGGAEQ + E ERSLHDAIMIV+RA++N +VAGGGA EME+SK LRDYS Sbjct: 365 PKAKTCTIILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYS 424 Query: 429 KTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFETENI 488 +TI GKQQ++I A+AKALE+IPRQLC+NAGFDA ILNKLR H++G WYGV TE+I Sbjct: 425 RTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGMWYGVDINTEDI 484 Query: 489 GDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGS 529 DNF FVWEPA+V+INAL +A+EA LI+SVDETI N S Sbjct: 485 ADNFEAFVWEPAMVRINALTAASEAACLIVSVDETIKNPRS 525 >1Q3S-A nrPDB Length = 548 Score = 577 bits (1488), Expect = e-165, Method: Composition-based stats. Identities = 175/528 (33%), Positives = 289/528 (54%), Gaps = 11/528 (2%) Query: 10 IVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATI 69 +V+L EGT G+ NI A + E ++ TLGP G D ++V S ++ND ATI Sbjct: 9 VVILPEGTQRYVGRDAQRLNILAARIIAETVRTTLGPKGMDKMLVDSLGDIVVTNDCATI 68 Query: 70 LKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGY 129 L +D+ HPAAK +V++++ QD E GDGTT+ ++AGEL+++A+ L++ I +I+KGY Sbjct: 69 LDKIDLQHPAAKMMVEVAKTQDKEAGDGTTTAVVIAGELLRKAEELLDQNIHPSIIIKGY 128 Query: 130 RKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSL 189 A A E ++E+A+ + + E L + A T+++ K ++ + K+ V+AV + Sbjct: 129 ALAAEKAQEILDEIAIRVDPDD---EETLLKIAATSITGKNAESHKELLAKLAVEAVKQV 185 Query: 190 DRND-----LDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSL 244 +D I +K G +EES + GV K + + PK+ N KI + Sbjct: 186 AEKKDGKYVVDLDNIKFEKKAGEGVEESELVRGVVIDKEVVHP---RMPKRVENAKIALI 242 Query: 245 NVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLAT 304 N LE+K + +A++ + + + ++ E +++ + + + +TGAN+V + I DLA Sbjct: 243 NEALEVKKTETDAKINITSPDQLMSFLEQEEKMLKDMVDHIAQTGANVVFVQKGIDDLAQ 302 Query: 305 QFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNL 364 + A I RV DM ++ +A G I + D+ PE LG + EE ++ E Sbjct: 303 HYLAKYGIMAVRRVKKSDMEKLAKATGAKIVTNVKDLTPEDLGYAEVVEERKLAGENMIF 362 Query: 365 FQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCL 424 +GC K T+L+RGG E VI EVER+L DA+ +VK +++ ++ GGA E+E++ L Sbjct: 363 VEGCKNPKAVTILIRGGTEHVIDEVERALEDAVKVVKDVMEDGAVLPAGGAPEIELAIRL 422 Query: 425 RDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFE 484 +Y+K + GK+ + I FA AL++IP+ L ENAG D +E+L K+ H G+ Sbjct: 423 DEYAKQVGGKEALAIENFADALKIIPKTLAENAGLDTVEMLVKVISEHKNRGLGIGIDVF 482 Query: 485 TENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESA 532 D K + EP VK A+ SA+EA +IL +D+ I K ++ Sbjct: 483 EGKPADMLEKGIIEPLRVKKQAIKSASEAAIMILRIDDVIAAKATKPE 530 >4XCG-B nrPDB Length = 557 Score = 574 bits (1480), Expect = e-164, Method: Composition-based stats. Identities = 185/533 (34%), Positives = 304/533 (57%), Gaps = 12/533 (2%) Query: 10 IVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATI 69 +++LKEG+ + GK + +NI A A++EALK T GP G D ++V S TI+NDGATI Sbjct: 18 VIILKEGSSRTYGKEALRANIAAVKAIEEALKSTYGPRGMDKMLVDSLGDITITNDGATI 77 Query: 70 LKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGY 129 L +D+ HP K LV I++ QD E DGT + ILAGEL K+A+ L + I +I+ GY Sbjct: 78 LDKMDLQHPTGKLLVQIAKGQDEETADGTKTAVILAGELAKKAEDLLYKEIHPTIIVSGY 137 Query: 130 RKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSL 189 +KA +A++ I E+A +T + ++L + A T++ SK + ++ + V AV + Sbjct: 138 KKAEEIALKTIQEIAQPVTINDT---DVLRKVALTSLGSKAVAGAREYLADLVVKAVAQV 194 Query: 190 -----DRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSL 244 D+ +D + I K GG++ ++ + G+ K + G PK+ N KI L Sbjct: 195 AELRGDKWYVDLDNVQIVKKHGGSVNDTQLVYGIVVDKEVVHPGM---PKRIENAKIALL 251 Query: 245 NVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLAT 304 + LE++ + +AE+R+ ++ E ++ EK+ ++ TGAN+V+ + I ++A Sbjct: 252 DASLEVEKPELDAEIRINDPTQMHKFLEEEENILKEKVDKIAATGANVVICQKGIDEVAQ 311 Query: 305 QFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNL 364 + A + I R D+ ++ +A GG + S ++ + LG AL EE ++G ++ Sbjct: 312 HYLAKKGILAVRRAKKSDLEKLARATGGRVISNIDELTSQDLGYAALVEERKVGEDKMVF 371 Query: 365 FQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCL 424 +G K+ ++L+RGG E+V+ E ER+L DA+ V +++ VAGGGA E+E++K L Sbjct: 372 VEGAKNPKSVSILIRGGLERVVDETERALRDALGTVADVIRDGRAVAGGGAVEIEIAKRL 431 Query: 425 RDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAH-SKGEKWYGVVF 483 R Y+ + GK+Q+ I A+A A+E + L ENAG D I+ L +LR H ++ KWYG+ Sbjct: 432 RKYAPQVGGKEQLAIEAYANAIEGLIMILAENAGLDPIDKLMQLRSLHENETNKWYGLNL 491 Query: 484 ETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESANAGM 536 T N D + V EPALVK+NA+ +ATEA L+L +D+ + + Sbjct: 492 FTGNPEDMWKLGVIEPALVKMNAVKAATEAVTLVLRIDDIVAAGKKSGSEPSG 544 >1A6E-A nrPDB Length = 545 Score = 572 bits (1475), Expect = e-163, Method: Composition-based stats. Identities = 201/533 (37%), Positives = 305/533 (57%), Gaps = 14/533 (2%) Query: 6 QTPTIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISND 65 Q P I+VLKEGT QGK +NI A A+ +A++ TLGP G D ++V S ISND Sbjct: 5 QVP-ILVLKEGTQREQGKNAQRNNIEAAKAIADAVRTTLGPKGMDKMLVDSIGDIIISND 63 Query: 66 GATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLI 125 GATILK +DV HP AK +V++S+AQD VGDGTT+ +L+GEL+K+A+ L++G+ +I Sbjct: 64 GATILKEMDVEHPTAKMIVEVSKAQDTAVGDGTTTAVVLSGELLKQAETLLDQGVHPTVI 123 Query: 126 MKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDA 185 GYR AV+ A + I+E+A EKS+ L + A TA+S K + DF + V A Sbjct: 124 SNGYRLAVNEARKIIDEIA-----EKSTDDATLRKIALTALSGKNTGLSNDFLADLVVKA 178 Query: 186 VLSLDR-----NDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPK 240 V ++ +D I + K GG++ ++ FI+G+ K ++ + P N K Sbjct: 179 VNAVAEVRDGKTIVDTANIKVDKKNGGSVNDTQFISGIVIDKEKVHS---KMPDVVKNAK 235 Query: 241 ILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIG 300 I ++ LE+K + A+V++ Q ++ E + + +++++GAN+VL + I Sbjct: 236 IALIDSALEIKKTEIEAKVQISDPSKIQDFLNQETNTFKQMVEKIKKSGANVVLCQKGID 295 Query: 301 DLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSE 360 D+A + A I+ RV DM ++ +A G I + D+ P LG EE +IG + Sbjct: 296 DVAQHYLAKEGIYAVRRVKKSDMEKLAKATGAKIVTDLDDLTPSVLGEAETVEERKIGDD 355 Query: 361 RYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEV 420 R GC K ++L+RGG + V++EVER+L+DAI +V ++ + GGGA E E+ Sbjct: 356 RMTFVMGCKNPKAVSILIRGGTDHVVSEVERALNDAIRVVAITKEDGKFLWGGGAVEAEL 415 Query: 421 SKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYG 480 + L Y+ ++ G++Q+ I AFAKALE+IPR L ENAG D I L KL+ KG G Sbjct: 416 AMRLAKYANSVGGREQLAIEAFAKALEIIPRTLAENAGIDPINTLIKLKADDEKGRISVG 475 Query: 481 VVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESAN 533 V + +GD AK V +P VK +AL SA E +IL +D+ I +K S + Sbjct: 476 VDLDNNGVGDMKAKGVVDPLRVKTHALESAVEVATMILRIDDVIASKKSTPPS 528 >3J1C-A nrPDB Length = 563 Score = 570 bits (1470), Expect = e-163, Method: Composition-based stats. Identities = 179/530 (33%), Positives = 298/530 (56%), Gaps = 15/530 (2%) Query: 10 IVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATI 69 +++ KEGT + G+ + +NI A + E L+ +LGP G D +++ S TI+NDGATI Sbjct: 7 VLLFKEGTSRNSGRDALKNNILAARTLAEMLRSSLGPKGLDKMLIDSFGDVTITNDGATI 66 Query: 70 LKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGY 129 +K +++ HPAAK LV+ ++AQD+EVGDGTTS +LAG +++A+ +++ I +I++G+ Sbjct: 67 VKEMEIQHPAAKLLVEAAKAQDSEVGDGTTSAVVLAGLFLEKAESLVDQNIHPTIIIEGF 126 Query: 130 RKAVSLAVEKINELAVDITSEK---SSGRELLERCARTAMSSKLIHNNADF--FVKMCVD 184 +KA + ++E + +LA + ++ R+ L++ T MSSK + + + + +D Sbjct: 127 KKAFNKSLELLPQLATKVDVSDLNSATARDALKKIVYTTMSSKFMAEGEELNKIMDIVID 186 Query: 185 AVLSLDR------NDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNN 238 AV ++ ++ LI I K GG +E+S I G+ K +AG P++ Sbjct: 187 AVTTVAEPLPDGGYNVSLDLIKIDKKKGGTIEDSQLIRGIVLDKEVVHAGM---PRRVEK 243 Query: 239 PKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLP 298 KI L+ LE++ + +A++ + + +A +D E + + + + ++ GAN+V+ + Sbjct: 244 AKIAVLDASLEVEKPEISAKISITSPDQIKAFLDEEAKYLKDMVDKLASIGANVVICQKG 303 Query: 299 IGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIG 358 I D+A F A R I RV D+ ++ +A+G I S+ D PE LG L EE ++G Sbjct: 304 IDDIAQHFLAKRGILAVRRVKRSDIEKLEKALGARIISSIKDATPEDLGYAELVEERKVG 363 Query: 359 SERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEM 418 +++ +G K +LLRG + + E ERS++DA+ ++ L IV GGGA E+ Sbjct: 364 NDKMVFIEGAKNPKAVNILLRGSNDMALDEAERSINDALYSLRNILMEPYIVPGGGAIEL 423 Query: 419 EVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKW 478 E+S LR+Y++++ GK+Q+ I A+A ALE IP L E AG + I L LR H+KG Sbjct: 424 ELSARLREYARSVGGKEQLAIEAYADALEEIPMILAETAGLEPISALMDLRARHAKGLTN 483 Query: 479 YGVVFETENI-GDNFAKFVWEPALVKINALNSATEATNLILSVDETITNK 527 GV I D ++ V EP V L SATEA I+ +D+ I Sbjct: 484 CGVDVINGKIIDDIYSINVVEPIRVTRQVLKSATEAATSIMKIDDLIAAS 533 >3J1E-A nrPDB Length = 553 Score = 568 bits (1465), Expect = e-162, Method: Composition-based stats. Identities = 191/541 (35%), Positives = 313/541 (57%), Gaps = 16/541 (2%) Query: 10 IVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATI 69 +++LKEG+ + GK + +NI A AV+EALK T GP G D ++V S TI+NDGATI Sbjct: 16 VIILKEGSSRTYGKEAVRANIAAVKAVEEALKSTYGPRGMDKMLVDSLGDITITNDGATI 75 Query: 70 LKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGY 129 L +D+ HPAAK LV I++ QD E DGT + I +GEL+K+A+ L + + +I+ GY Sbjct: 76 LDKMDLQHPAAKLLVQIAKGQDEETADGTKTAVIFSGELVKKAEDLLYKDVHPTIIISGY 135 Query: 130 RKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSL 189 +KA +A++ I ELA ++ + +LL + A T++SSK + ++ + V AV + Sbjct: 136 KKAEEVALQTIQELAQTVSINDT---DLLRKIAMTSLSSKAVAGAREYIADIVVKAVTQV 192 Query: 190 -----DRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSL 244 D+ +D I I K GG++ ++ + G+ K + G PK+ N KI + Sbjct: 193 AELRGDKWYVDLDNIQIVKKAGGSINDTQLVYGIVVDKEVVHPGM---PKRLENAKIALI 249 Query: 245 NVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLAT 304 + LE++ + +AE+R+ Q +D E LI EK+ ++ TGAN+++ + I ++A Sbjct: 250 DASLEVEKPELDAEIRINDPTQMQKFLDEEENLIKEKVDKILATGANVIICQKGIDEVAQ 309 Query: 305 QFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNL 364 + A + + R D+ ++ +A GG + S +I + LG +L EE ++G ++ Sbjct: 310 SYLAKKGVLAVRRAKKSDLEKLARATGGRVVSNIDEISEQDLGYASLIEERKVGEDKMVF 369 Query: 365 FQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCL 424 +G K+ ++L+RGG E+++ E ER+L DA+ V +++ +AGGGA E+E++K L Sbjct: 370 VEGAKNPKSISILIRGGLERLVDETERALRDALGTVADVIKDGRAIAGGGAVEIEIAKKL 429 Query: 425 RDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAH-SKGEKWYGVVF 483 R Y+ + GK+Q+ + A+A ALE + L ENAGFD I++L KLR H ++ KWYG+ Sbjct: 430 RKYAPQVGGKEQLAVEAYANALESLVSILIENAGFDPIDLLMKLRSTHENENNKWYGIDL 489 Query: 484 ETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETIT----NKGSESANAGMMPP 539 D + K V EPALVK+NA+ +ATEA L+L +D+ ++ + G G P Sbjct: 490 YAGQPVDMWQKGVIEPALVKMNAIKAATEAATLVLRIDDVVSAGKKSGGESKTPGGANKP 549 Query: 540 Q 540 Sbjct: 550 S 550 >4XCI-A nrPDB Length = 559 Score = 567 bits (1461), Expect = e-162, Method: Composition-based stats. Identities = 191/550 (34%), Positives = 311/550 (56%), Gaps = 15/550 (2%) Query: 10 IVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATI 69 +++LKEGT + G+ + +NI A + E L+ +LGP G D +++ S TI+NDGATI Sbjct: 5 VLLLKEGTSRTTGRDALRNNILAAKTLAEMLRSSLGPKGLDKMLIDSFGDVTITNDGATI 64 Query: 70 LKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGY 129 +K +++ HPAAK LV+ ++AQDAEVGDGTTS +LAG L+++A+ L++ I +I++GY Sbjct: 65 VKDMEIQHPAAKLLVEAAKAQDAEVGDGTTSAVVLAGALLEKAESLLDQNIHPTIIIEGY 124 Query: 130 RKAVSLAVEKINELAVDITSEK---SSGRELLERCARTAMSSKLIHNNADF--FVKMCVD 184 +KA + A+E + +L I + S R+ L + A T ++SK I A+ + M +D Sbjct: 125 KKAYNKALELLPQLGTRIDIKDLNSSVARDTLRKIAFTTLASKFIAEGAELNKIIDMVID 184 Query: 185 AVLSLDR------NDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNN 238 A++++ ++ LI I K GG++E+S+ + G+ K + G P++ Sbjct: 185 AIVNVAEPLPNGGYNVSLDLIKIDKKKGGSIEDSVLVKGLVLDKEVVHPGM---PRRVTK 241 Query: 239 PKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLP 298 KI L+ LE++ + +A++ + E +A +D E + + + + ++ GAN+V+ + Sbjct: 242 AKIAVLDAALEVEKPEISAKISITSPEQIKAFLDEESKYLKDMVDKLASIGANVVICQKG 301 Query: 299 IGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIG 358 I D+A F A + I RV D+ ++ +A+G I S+ D PE LG L EE ++G Sbjct: 302 IDDIAQHFLAKKGILAVRRVKRSDIEKLEKALGARIISSIKDATPEDLGYAELVEERRVG 361 Query: 359 SERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEM 418 +++ +G K +LLRG + + E ERS++DA+ ++ L +I+ GGGA E+ Sbjct: 362 NDKMVFIEGAKNLKAVNILLRGSNDMALDEAERSINDALHALRNILLEPVILPGGGAIEL 421 Query: 419 EVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKW 478 E++ LR+Y++++ GK+Q+ I AFA ALE IP L E AG +AI L LR H+KG Sbjct: 422 ELAMKLREYARSVGGKEQLAIEAFADALEEIPLILAETAGLEAISSLMDLRARHAKGLSN 481 Query: 479 YGVVFETENIG-DNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESANAGMM 537 GV I D +A + EP VK L SATEA IL +D+ I +S G Sbjct: 482 TGVDVIGGKIVDDVYALNIIEPIRVKSQVLKSATEAATAILKIDDLIAAAPLKSEKKGGE 541 Query: 538 PPQGAGRGRG 547 + G G Sbjct: 542 GSKEESGGEG 551 >1A6D-B nrPDB Length = 543 Score = 563 bits (1451), Expect = e-161, Method: Composition-based stats. Identities = 188/522 (36%), Positives = 297/522 (56%), Gaps = 11/522 (2%) Query: 10 IVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATI 69 I +LKEGT GK + NI A +A+ +++ +LGP G D ++V S I+NDG TI Sbjct: 7 IFILKEGTKRESGKDAMKENIEAAIAISNSVRSSLGPRGMDKMLVDSLGDIVITNDGVTI 66 Query: 70 LKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGY 129 LK +DV HPAAK +V++S+ QD+ VGDGTT+ I+AG L+++A+ + + + +I +GY Sbjct: 67 LKEMDVEHPAAKMMVEVSKTQDSFVGDGTTTAVIIAGGLLQQAQGLINQNVHPTVISEGY 126 Query: 130 RKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSL 189 R A A I+E++ I +++ + LL + A+T+++SK D ++ +AV S+ Sbjct: 127 RMASEEAKRVIDEISTKIGADE---KALLLKMAQTSLNSKSASVAKDKLAEISYEAVKSV 183 Query: 190 DR-----NDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSL 244 +D I + K GGA++++ ING+ K + G P + KI L Sbjct: 184 AELRDGKYYVDFDNIQVVKKQGGAIDDTQLINGIIVDKEKVHPGM---PDVVKDAKIALL 240 Query: 245 NVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLAT 304 + LE+K + + +R+E Q + E ++ E + +++ GAN+V+++ I D+A Sbjct: 241 DAPLEIKKPEFDTNLRIEDPSMIQKFLAQEENMLREMVDKIKSVGANVVITQKGIDDMAQ 300 Query: 305 QFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNL 364 + + I+ RV DM+++ +A G SI ST +I LGT E++++G + Sbjct: 301 HYLSRAGIYAVRRVKKSDMDKLAKATGASIVSTIDEISSSDLGTAERVEQVKVGEDYMTF 360 Query: 365 FQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCL 424 GC K ++L+RG E V+ E+ERS+ D++ +V AL++ AGGGAT E++ L Sbjct: 361 VTGCKNPKAVSILVRGETEHVVDEMERSITDSLHVVASALEDGAYAAGGGATAAEIAFRL 420 Query: 425 RDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFE 484 R Y++ I G+QQ+ I FA A+E IPR L ENAG D I+IL KLR H+KG K YG+ Sbjct: 421 RSYAQKIGGRQQLAIEKFADAIEEIPRALAENAGLDPIDILLKLRAEHAKGNKTYGINVF 480 Query: 485 TENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITN 526 T I D V EP V A+ SATEA +IL +D+ I Sbjct: 481 TGEIEDMVKNGVIEPIRVGKQAIESATEAAIMILRIDDVIAT 522 >3RUW-A nrPDB Length = 543 Score = 562 bits (1449), Expect = e-160, Method: Composition-based stats. Identities = 181/531 (34%), Positives = 303/531 (57%), Gaps = 11/531 (2%) Query: 5 SQTPTIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISN 64 SQ P + L E G+ NI A + E ++ TLGP G D ++V ++N Sbjct: 2 SQQPGV--LPENMKRYMGRDAQRMNILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVVTN 59 Query: 65 DGATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHL 124 DG TIL+ + V HPAAK L+++++ Q+ EVGDGTT+ ++AGEL+++A+ L++ + + Sbjct: 60 DGVTILREMSVEHPAAKMLIEVAKTQEKEVGDGTTTAVVVAGELLRKAEELLDQNVHPTI 119 Query: 125 IMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVD 184 ++KGY+ A A E + +A ++ ++ +E+L + A T+++ K + ++ V+ Sbjct: 120 VVKGYQAAAQKAQELLKTIACEVGAQD---KEILTKIAMTSITGKGAEKAKEKLAEIIVE 176 Query: 185 AVLSL--DRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKIL 242 AV ++ D +D LI I+K G +++++ I GV K A Q PKK + KI Sbjct: 177 AVSAVVDDEGKVDKDLIKIEKKSGASIDDTELIKGVLVDKERVSA---QMPKKVTDAKIA 233 Query: 243 SLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDL 302 LN +E+K + +AE+R+ ++ E +++ + + +++ +GAN++ + I DL Sbjct: 234 LLNCAIEIKETETDAEIRITDPAKLMEFIEQEEKMLKDMVAEIKASGANVLFCQKGIDDL 293 Query: 303 ATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERY 362 A + A I A RV DM ++ +A G ++ + + + + LG L EE +I + Sbjct: 294 AQHYLAKEGIVAARRVKKSDMEKLAKATGANVIAAIAALSAQDLGDAGLVEERKISGDSM 353 Query: 363 NLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSK 422 + C K T+L+RG E VI EV R++ DA+ +V +++ IV+GGG+TE+E+S Sbjct: 354 IFVEECKHPKAVTMLIRGTTEHVIEEVARAVDDAVGVVGCTIEDGRIVSGGGSTEVELSM 413 Query: 423 CLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHS-KGEKWYGV 481 LR+Y++ I+G++Q+ + AFA ALEVIPR L ENAG DAIEIL K+R AH+ G K G+ Sbjct: 414 KLREYAEGISGREQLAVRAFADALEVIPRTLAENAGLDAIEILVKVRAAHASNGNKCAGL 473 Query: 482 VFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESA 532 T + D V EP VK A+ SA E+T ++L +D+ I + A Sbjct: 474 NVFTGAVEDMCENGVVEPLRVKTQAIQSAAESTEMLLRIDDVIAAEKLRGA 524 >4B2T-G nrPDB Length = 545 Score = 559 bits (1441), Expect = e-159, Method: Composition-based stats. Identities = 171/543 (31%), Positives = 293/543 (53%), Gaps = 17/543 (3%) Query: 10 IVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATI 69 ++VL + T G+ NINA + + ++ LGP +++ ++NDG I Sbjct: 7 VLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAI 66 Query: 70 LKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGY 129 L+ + V HPAAK++++ISR QD EVGDGTTSV ILAGE++ A+ FLE+ + +++ Y Sbjct: 67 LREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAY 126 Query: 130 RKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSL 189 RKA+ + + ++++ + +S R+ + +++++K+I + + +DAV ++ Sbjct: 127 RKALDDMISTLKKISIPV---DTSNRDTMLNIINSSITTKVISRWSSLACNIALDAVKTV 183 Query: 190 D-----RNDLD-DKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILS 243 R ++D K ++KIPGG +E+S + GV K ++ + NP+I+ Sbjct: 184 QFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMR---RYIKNPRIVL 240 Query: 244 LNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLA 303 L+ LE K + ++ + ED+ I+ E + I + + + ++V+++ I DLA Sbjct: 241 LDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLA 300 Query: 304 TQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGT-CALFEEMQIGSERY 362 + NI RV D NR+ +A G I S +++ E +GT L E +IG E + Sbjct: 301 QHYLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREEDVGTGAGLLEIKKIGDEYF 360 Query: 363 NLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSK 422 C K CT+LLRG ++++++EVER+L DA+ + + L + +V GGGA+EM V+ Sbjct: 361 TFITECKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAH 420 Query: 423 CLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGE-KWYGV 481 L + SK + G +Q A A+ALEVIPR L +N G I +L LR H++ + +GV Sbjct: 421 ALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETWGV 480 Query: 482 VFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETIT---NKGSESANAGMMP 538 ET + D +WEP VK+ +A E L+L +D+ ++ KG + + G P Sbjct: 481 NGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQSRQGGAP 540 Query: 539 PQG 541 G Sbjct: 541 DAG 543 >5UYZ-A nrPDB Length = 541 Score = 546 bits (1406), Expect = e-155, Method: Composition-based stats. Identities = 162/532 (30%), Positives = 284/532 (53%), Gaps = 13/532 (2%) Query: 8 PTIVVLKEGTD-ASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDG 66 P +++ + G + S+I A AV ++ +LGP G D ++V + T++NDG Sbjct: 15 PFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDG 74 Query: 67 ATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIM 126 ATIL ++DV H AK +V++S++QD E+GDGTT V +LAG L++EA+ L+ GI I Sbjct: 75 ATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIA 134 Query: 127 KGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAV 186 GY +A +A+E++++++ + + L + A+T + SK++++ ++ V+AV Sbjct: 135 DGYEQAARVAIERLDKISDSVLVDIKDTEP-LIQTAKTTLGSKVVNSCHRQMAEIAVNAV 193 Query: 187 LSL---DRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILS 243 L++ +R D+D +LI ++ GG +E++ I GV K FS+ Q PKK + KI Sbjct: 194 LTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHP---QMPKKVEDAKIAI 250 Query: 244 LNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLA 303 L E K ++ V VEDY+A+ E + E ++Q++ETGAN+ + + D A Sbjct: 251 LTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEA 310 Query: 304 TQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGS--ER 361 N+ V ++ + A GG I S++ E LG L +E+ G+ ++ Sbjct: 311 NHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDK 370 Query: 362 YNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVS 421 + + C ++ T+ +RGG + +I E +RSLHDA+ +++ +++ +V GGGA E+ + Sbjct: 371 MLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCA 430 Query: 422 KCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKG-EKWYG 480 + + +Q + AFA ALEVIP L EN+G + I+ + ++R K G Sbjct: 431 LAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALG 490 Query: 481 VVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESA 532 + + D + V E + K ++ AT+ +IL +D+ K ES Sbjct: 491 IDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDI--RKPGESE 540 >4V8R-AE nrPDB Length = 562 Score = 545 bits (1405), Expect = e-155, Method: Composition-based stats. Identities = 164/537 (30%), Positives = 275/537 (51%), Gaps = 17/537 (3%) Query: 8 PTIVVLKEGTDASQ-GKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDG 66 P I+V +G Q G S+I A +V +K +LGP G D ++++ + + TI+NDG Sbjct: 28 PFIIVKDQGNKKRQHGLEAKKSHILAARSVASIIKTSLGPRGLDKILISPDGEITITNDG 87 Query: 67 ATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIM 126 ATIL +++ + AK LV +S++QD E+GDGTT V +LA L+ +A +++GI I Sbjct: 88 ATILSQMELDNEIAKLLVQLSKSQDDEIGDGTTGVVVLASALLDQALELIQKGIHPIKIA 147 Query: 127 KGYRKAVSLAVEKINELAVDIT-SEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDA 185 G+ +A LA+ K+ E DI+ S R+ L R A+T++ SK++ + D F +M V+A Sbjct: 148 NGFDEAAKLAISKLEETCDDISASNDELFRDFLLRAAKTSLGSKIVSKDHDRFAEMAVEA 207 Query: 186 VLSL---DRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKF------ 236 V+++ DR D+D LI ++ GG++ +S INGV K FS+ Q PK Sbjct: 208 VINVMDKDRKDVDFDLIKMQGRVGGSISDSKLINGVILDKDFSHP---QMPKCVLPKEGS 264 Query: 237 NNPKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSK 296 + K+ L E K ++ + VE+YQ + E E + V++ GA++V+ + Sbjct: 265 DGVKLAILTCPFEPPKPKTKHKLDISSVEEYQKLQTYEQDKFKEMIDDVKKAGADVVICQ 324 Query: 297 LPIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQ 356 D A ++ V ++ + + G I D+ + LGTC+ E + Sbjct: 325 WGFDDEANHLLLQNDLPAVRWVGGQELEHIAISTNGRIVPRFQDLSKDKLGTCSRIYEQE 384 Query: 357 IGS--ERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGG 414 G+ +R + + + KT T +RG + ++ E ER+LHD++ +V+ +++ +V GGG Sbjct: 385 FGTTKDRMLIIEQSKETKTVTCFVRGSNKMIVDEAERALHDSLCVVRNLVKDSRVVYGGG 444 Query: 415 ATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSK 474 A E+ +S + + + G Q FA+AL+ IP L EN+G D I L+ L+ K Sbjct: 445 AAEVTMSLAVSEEADKQRGIDQYAFRGFAQALDTIPMTLAENSGLDPIGTLSTLKSKQLK 504 Query: 475 GE-KWYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSE 530 + GV D FV +P + K + AT+ +IL +D I + E Sbjct: 505 EKISNIGVDCLGYGSNDMKELFVVDPFIGKKQQILLATQLCRMILKIDNVIISGKDE 561 >3IYF-A nrPDB Length = 521 Score = 533 bits (1373), Expect = e-152, Method: Composition-based stats. Identities = 177/531 (33%), Positives = 292/531 (54%), Gaps = 33/531 (6%) Query: 5 SQTPTIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISN 64 SQ P + L E G+ NI A + E ++ TLGP G D ++V ++N Sbjct: 2 SQQPGV--LPENMKRYMGRDAQRMNILAGRIIAETVRSTLGPKGMDKMLVDDLGDVVVTN 59 Query: 65 DGATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHL 124 DG TIL+ + V HPAAK L+++++ Q+ EVGDGTT+ ++AGEL+++A+ L++ + + Sbjct: 60 DGVTILREMSVEHPAAKMLIEVAKTQEKEVGDGTTTAVVVAGELLRKAEELLDQNVHPTI 119 Query: 125 IMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVD 184 ++KGY+ A A E + +A ++ ++ +E+L + A T+++ K + ++ V+ Sbjct: 120 VVKGYQAAAQKAQELLKTIACEVGAQD---KEILTKIAMTSITGKGAEKAKEKLAEIIVE 176 Query: 185 AVLSL--DRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKIL 242 AV ++ D +D LI I+K G +++++ I GV K A Q PKK + KI Sbjct: 177 AVSAVVDDEGKVDKDLIKIEKKSGASIDDTELIKGVLVDKERVSA---QMPKKVTDAKIA 233 Query: 243 SLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDL 302 LN +E + +++ + + +++ +GAN++ + I DL Sbjct: 234 LLNCAIE----------------------ETASEMLKDMVAEIKASGANVLFCQKGIDDL 271 Query: 303 ATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERY 362 A + A I A RV DM ++ +A G ++ + D+ + LG L EE +I + Sbjct: 272 AQHYLAKEGIVAARRVKKSDMEKLAKATGANVITNIKDLSAQDLGDAGLVEERKISGDSM 331 Query: 363 NLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSK 422 + C K T+L+RG E VI EV R++ DA+ +V +++ IV+GGG+TE+E+S Sbjct: 332 IFVEECKHPKAVTMLIRGTTEHVIEEVARAVDDAVGVVGCTIEDGRIVSGGGSTEVELSM 391 Query: 423 CLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHS-KGEKWYGV 481 LR+Y++ I+G++Q+ + AFA ALEVIPR L ENAG DAIEIL K+R AH+ G K G+ Sbjct: 392 KLREYAEGISGREQLAVRAFADALEVIPRTLAENAGLDAIEILVKVRAAHASNGNKCAGL 451 Query: 482 VFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESA 532 T + D V EP VK A+ SA E+T ++L +D+ I + A Sbjct: 452 NVFTGAVEDMCENGVVEPLRVKTQAIQSAAESTEMLLRIDDVIAAEKLRGA 502 >5GW5-g nrPDB Length = 534 Score = 525 bits (1353), Expect = e-149, Method: Composition-based stats. Identities = 157/534 (29%), Positives = 290/534 (54%), Gaps = 21/534 (3%) Query: 6 QTPTIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISND 65 Q P +V + + + G+ ISNI A AV + ++ LGP +++ ++ND Sbjct: 2 QAP-VVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND 60 Query: 66 GATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKP-FLEEGISSHL 124 G IL+ +DV HPAAK+++++SR QD EVGDGTT+V ILAGE++ + P +E+ I + Sbjct: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 Query: 125 IMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVD 184 I++ +KA++ A+E I +++ + E + +++ + ++ +K + + ++ ++ +D Sbjct: 121 IIQALKKALTDALEVIKQVSKPVDVENDAA---MKKLIQASIGTKYVIHWSEKMCELALD 177 Query: 185 AVLSLDRNDLD------------DKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQ 232 AV ++ ++ + + ++KIPGG + +S + GV K + + Sbjct: 178 AVKTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHP---KM 234 Query: 233 PKKFNNPKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANI 292 + NP+++ L+ LE K + + +E ED+ I+ E + + Q+ + Sbjct: 235 SRHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTL 294 Query: 293 VLSKLPIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGT-CAL 351 V+++ + DLA + RV D NR+ + G +I + D+K +GT C L Sbjct: 295 VITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGL 354 Query: 352 FEEMQIGSERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVA 411 F+ IG E ++ C + K CT++LRGG++ ++ E++R+L DA+ + + + + + Sbjct: 355 FKVEMIGDEYFSFLDNCKEPKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSP 414 Query: 412 GGGATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLA 471 GGGATEM VS L + +K + G QQ A A A+E IPR L +NAG D I +L++LR Sbjct: 415 GGGATEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAK 474 Query: 472 HSKGEKWYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETIT 525 H++G G+ + I D + +WEP ++K ++ +A E+ L+L VD+ ++ Sbjct: 475 HAQGNFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVS 528 >3AQ1-B nrPDB Length = 500 Score = 520 bits (1340), Expect = e-148, Method: Composition-based stats. Identities = 170/493 (34%), Positives = 281/493 (56%), Gaps = 14/493 (2%) Query: 52 LIVTSNQKTTISNDGATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKE 111 ++V S I+NDGATILK +D+ HPAAK +V++S+ QDAEVGDGTT+ +L+GEL+ + Sbjct: 1 MLVDSMGDIVITNDGATILKEMDIQHPAAKMIVEVSKTQDAEVGDGTTTAAVLSGELLSK 60 Query: 112 AKPFLEEGISSHLIMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLI 171 A+ + +G+ S +I +GYR A E + + + I+ + + L + A TA++ K Sbjct: 61 AEELIMKGVHSTIISEGYRHAAEKCREILETITIAISPDDEAA---LIKIAGTAITGKGA 117 Query: 172 HNNADFFVKMCVDAVLSLDRNDLD------DKLIGIKKIPGGAMEESLFINGVAFKKTFS 225 + + V AV S+ + D + I I+K GG++++S I+G+ K S Sbjct: 118 EAYKEKLSALTVKAVRSIVEEEEDGLKVNVLENIKIEKRAGGSIDDSELIDGLVIDKERS 177 Query: 226 YAGFEQQPKKFNNPKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQV 285 + P+K N KIL L+ +E + + ++E+++ Q +D E +++ E +V Sbjct: 178 HP---NMPEKVENAKILLLSCPVEFRKTEVDSEIKITSPGQMQLFLDQEEKMMREMAEKV 234 Query: 286 EETGANIVLSKLPIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEH 345 +GAN+V + I D+A + I+ RV D+ R+ + G +I I E Sbjct: 235 IASGANVVFCQKGIDDMAQYYIEKAGIYAVRRVKKSDLKRLSKVTGATIIQDLDQITTED 294 Query: 346 LGTCALFEEMQIGSERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQ 405 +GT L EE ++ + GC +K T+LL GG E V+ ++ +L+DA+ +V ++ Sbjct: 295 VGTAGLVEEKEVRGGKMTYVTGCQNSKAVTVLLHGGTEHVVDSLDHALNDALHVVGVVIE 354 Query: 406 NKLIVAGGGATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEIL 465 + +V GGG++E+E+S L +Y+ T+ G++Q+ ++ FA+ALEVIP L ENAG D I+I+ Sbjct: 355 DGKVVVGGGSSEVELSLRLSEYASTLKGREQLAVSKFAEALEVIPVALAENAGLDPIDIM 414 Query: 466 NKLRLAHSKGEKWYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETIT 525 +LR H KG K G+ T + D + V EP +K A+N+A EAT +IL +D+ + Sbjct: 415 VELRSQHEKGNKNAGLNVYTGEVVDMWENDVIEPLRIKTQAINAAMEATVMILRIDDVVA 474 Query: 526 NKGSESANAGMMP 538 +KGS AN GM P Sbjct: 475 SKGS--ANQGMGP 485 >4B2T-D nrPDB Length = 542 Score = 517 bits (1331), Expect = e-147, Method: Composition-based stats. Identities = 164/522 (31%), Positives = 277/522 (53%), Gaps = 18/522 (3%) Query: 17 TDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVV 76 D + SNI+A AV +A++ +LGP G D +I TI+NDGATILK + V+ Sbjct: 28 QDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVL 87 Query: 77 HPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLA 136 HPAA+ LV++S+AQD E GDGTTSV I+AG L+ L++GI +I + ++KA+ Sbjct: 88 HPAARMLVELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKG 147 Query: 137 VEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSL----DRN 192 +E + +++ + + S RE L A T+++SK++ + M VDAV+ + Sbjct: 148 IEILTDMSRPV---ELSDRETLLNSAATSLNSKVVSQYSSLLSPMSVDAVMKVIDPATAT 204 Query: 193 DLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELELKA 252 +D + I I K GG +++ + G+ + + +G + KI + L Sbjct: 205 SVDLRDIKIVKKLGGTIDDCELVEGLVLTQKVANSGI----TRVEKAKIGLIQFCLSAPK 260 Query: 253 EKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPI-----GDLATQFF 307 + ++ V ++ E I ++Q+++TG N++L + I DLA F Sbjct: 261 TDMDNQIVVSDYVQMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFL 320 Query: 308 ADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQI-GSERYNLFQ 366 I + +D+ + + +G + + LG+ L EE+ + GS + Sbjct: 321 NKMKIMVVKDIEREDIEFICKTIGTKPVAHVDQFTADMLGSAELAEEVSLNGSGKLIKIT 380 Query: 367 GCPQA-KTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLR 425 GC KT T+++RG + VI E ERS+HDA+ +++ ++ + ++AGGGA E+E++ L Sbjct: 381 GCASPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLT 440 Query: 426 DYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFET 485 +YS+T++G + I AFA A+EVIP L ENAG + I + +LR H++GEK G+ Sbjct: 441 EYSRTLSGMESYCIRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTTGINVRK 500 Query: 486 ENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNK 527 I + + V +P LV ++AL ATE IL +D+ + + Sbjct: 501 GGISNILEELVVQPLLVSVSALTLATETVRSILKIDDVVNTR 542 >4B2T-A nrPDB Length = 556 Score = 516 bits (1330), Expect = e-147, Method: Composition-based stats. Identities = 184/548 (33%), Positives = 285/548 (52%), Gaps = 25/548 (4%) Query: 18 DASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVH 77 D S G+ N+ A ++ +K +LGP+G D ++V TI+NDGATILKLL+V H Sbjct: 10 DRSTGEAIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLLEVEH 69 Query: 78 PAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAV 137 PAAK L +++ QD EVGDGTTSV I+A EL+K A +++ I ++ GYR A AV Sbjct: 70 PAAKVLCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLACKEAV 129 Query: 138 EKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSLDRNDLDDK 197 I+E + T GR+ L A+T+MSSK+I N DFF + VDAVL++ D+ + Sbjct: 130 RYISENLIINT--DELGRDCLINAAKTSMSSKVIGINGDFFANLVVDAVLAIKYTDIRGQ 187 Query: 198 ------LIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELELK 251 I + K G + ES+ ING A G PK+ N KI L+ L+ Sbjct: 188 PRYPVNSINVLKAHGRSQMESMLINGYALNCVVGSQGM---PKRIVNAKIACLDFSLQKT 244 Query: 252 AEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRN 311 K +V + E I E + E+++++ TGAN++L+ I D+ ++F + Sbjct: 245 KMKLGVQVVITDPEKLDQIRQRESDITKERIQKILATGANVILTTGGIDDMCLKYFVEAG 304 Query: 312 IFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEH------LGTCALFEEMQIGSERYNLF 365 RV D+ R+ +A G ++ ST ++++ E LG + +I + L Sbjct: 305 AMAVRRVLKRDLKRIAKASGATVLSTLANLEGEETFEASMLGQAEEVVQERICDDELILI 364 Query: 366 QGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLR 425 + + +++LRG + + E+ERSLHDA+ +VKR L++K +V GGGA E +S L Sbjct: 365 KNTKARTSASVILRGANDFMCDEMERSLHDALCVVKRVLESKSVVPGGGAVEAALSIYLE 424 Query: 426 DYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHS--------KGEK 477 +Y+ ++ ++Q+ I FA++L VIP L NA D+ +++ KLR H+ K K Sbjct: 425 NYATSMGSREQLAIAEFARSLPVIPNTLAVNAAQDSTDLVAKLRAFHNEAQVNPERKNLK 484 Query: 478 WYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESANAGMM 537 W G+ DN V+EP +VK+ +L ATEA IL +D+ I + Sbjct: 485 WIGLDLVNGKPRDNKQAGVFEPTIVKVKSLKFATEAAITILRIDDLIKLHPESKDDKHGG 544 Query: 538 PPQGAGRG 545 G Sbjct: 545 YEDAVHSG 552 >4V8R-AG nrPDB Length = 590 Score = 495 bits (1275), Expect = e-140, Method: Composition-based stats. Identities = 157/590 (26%), Positives = 288/590 (48%), Gaps = 77/590 (13%) Query: 6 QTPTIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISND 65 Q P +V + + + G+ ISNI A AV + ++ LGP +++ ++ND Sbjct: 2 QAP-VVFMNASQERTTGRQAQISNITAAKAVADVIRTCLGPKAMLKMLLDPMGGLVLTND 60 Query: 66 GATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKP-FLEEGISSHL 124 G IL+ +DV HPAAK+++++SR QD EVGDGTT+V ILAGE++ + P +E+ I + Sbjct: 61 GHAILREIDVAHPAAKSMLELSRTQDEEVGDGTTTVIILAGEILAQCAPYLIEKNIHPVI 120 Query: 125 IMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVD 184 I++ +KA++ A+E I +++ + E + +++ + ++ +K + + ++ ++ +D Sbjct: 121 IIQALKKALTDALEVIKQVSKPVDVENDAA---MKKLIQASIGTKYVIHWSEKMCELALD 177 Query: 185 AVLSLDRNDLD------------DKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQ 232 AV ++ ++ + + ++KIPGG + +S + GV K + + Sbjct: 178 AVKTVRKDLGQTVEGEPNFEIDIKRYVRVEKIPGGDVLDSRVLKGVLLNKDVVHP---KM 234 Query: 233 PKKFNNPKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANI 292 + NP+++ L+ LE K + + +E ED+ I+ E + + Q+ + Sbjct: 235 SRHIENPRVVLLDCPLEYKKGESQTNIEIEKEEDWNRILQIEEEQVQLMCEQILAVRPTL 294 Query: 293 VLSKLPIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGT-CAL 351 V+++ + DLA + RV D NR+ + G +I + D+K +GT C L Sbjct: 295 VITEKGVSDLAQHYLLKGGCSVLRRVKKSDNNRIARVTGATIVNRVEDLKESDVGTNCGL 354 Query: 352 FEEMQIGSE------------------------------------------RYNLFQGC- 368 F+ IG E R+ Sbjct: 355 FKVEMIGDEYFSFLDNCKEPGSGSGWSHPQFEKGSGKRRWKKNFIAVSAANRFKKISSSG 414 Query: 369 -------------PQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGA 415 K CT++LRGG++ ++ E++R+L DA+ + + + + + GGGA Sbjct: 415 ALGSGHHHHHHHHGSGKACTIMLRGGSKDILNEIDRNLQDAMAVARNVMLSPSLSPGGGA 474 Query: 416 TEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKG 475 TEM VS L + +K + G QQ A A A+E IPR L +NAG D I +L++LR H++G Sbjct: 475 TEMAVSVKLAEKAKQLEGIQQWPYQAVADAMECIPRTLIQNAGGDPIRLLSQLRAKHAQG 534 Query: 476 EKWYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETIT 525 G+ + I D + +WEP ++K ++ +A E+ L+L VD+ ++ Sbjct: 535 NFTTGIDGDKGKIVDMVSYGIWEPEVIKQQSVKTAIESACLLLRVDDIVS 584 >4V94-A nrPDB Length = 559 Score = 494 bits (1272), Expect = e-140, Method: Composition-based stats. Identities = 173/543 (31%), Positives = 287/543 (52%), Gaps = 31/543 (5%) Query: 16 GTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDV 75 G + G N+ A +AV +K +LGP+G D ++V T++NDGATIL LLDV Sbjct: 16 GGEKISGDDIRNQNVLATMAVANVVKSSLGPVGLDKMLVDDIGDFTVTNDGATILSLLDV 75 Query: 76 VHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSL 135 HPA K LV++++ QD E+GDGTTSV I+A EL+K A ++ I I+ G+R A+ Sbjct: 76 QHPAGKILVELAQQQDREIGDGTTSVVIIASELLKRANELVKNKIHPTTIITGFRVALRE 135 Query: 136 AVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSLDRNDLD 195 A+ INE+ TS + G+E L A+T+MSSK+I ++DFF M VDA+L++ + Sbjct: 136 AIRFINEVL--STSVDTLGKETLINIAKTSMSSKIIGADSDFFSNMVVDALLAVKTQNSK 193 Query: 196 DKL------IGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKF--NNPKILSLNVE 247 ++ + + K G + ESL + G A T + + PK+ N KI L++ Sbjct: 194 GEIKYPVKAVNVLKAHGKSATESLLVPGYALNCTVAS---QAMPKRIAGGNVKIACLDLN 250 Query: 248 LELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFF 307 L+ ++ ++ E + I E ++ E+++++ + GA +VL+ I DL + F Sbjct: 251 LQKARMAMGVQINIDDPEQLEQIRKREAGIVLERVKKIIDAGAQVVLTTKGIDDLCLKEF 310 Query: 308 ADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEH------LGTCALFEEMQIGSER 361 + I R +D+ R+ +A G ++ S+ S+++ E LG C + + + Sbjct: 311 VEAKIMGVRRCKKEDLRRIARATGATLVSSMSNLEGEETFESSYLGLCDEVVQAKFSDDE 370 Query: 362 YNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVS 421 L +G + + +++LRG + + E+ERSLHD++ +VKR L++ +V GGG E ++ Sbjct: 371 CILIKGTSKHSSSSIILRGANDYSLDEMERSLHDSLSVVKRTLESGNVVPGGGCVEAALN 430 Query: 422 KCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHS-------- 473 L +++ T+ ++Q+ I FA AL +IP+ L NA D+ E++ KLR H+ Sbjct: 431 IYLDNFATTVGSREQLAIAEFAAALLIIPKTLAVNAAKDSSELVAKLRSYHAASQMAKPE 490 Query: 474 ----KGEKWYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGS 529 + + YG+ I D V EP + K+ +L SA EA IL +D IT Sbjct: 491 DVKRRSYRNYGLDLIRGKIVDEIHAGVLEPTISKVKSLKSALEACVAILRIDTMITVDPE 550 Query: 530 ESA 532 Sbjct: 551 PPK 553 >4B2T-B nrPDB Length = 535 Score = 492 bits (1266), Expect = e-139, Method: Composition-based stats. Identities = 174/527 (33%), Positives = 284/527 (53%), Gaps = 8/527 (1%) Query: 10 IVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQK--TTISNDGA 67 + + K G D + + +S+ +A+ + +K TLGP G D ++++S + ++NDGA Sbjct: 9 VNIFKAGADEERAETARLSSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGA 68 Query: 68 TILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMK 127 TILK + V +PAAK LVD+SR QD EVGDGTTSVT+LA EL++EA+ + + I I+ Sbjct: 69 TILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIA 128 Query: 128 GYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVL 187 G+R+A A + + AVD S++ R+ L A T +SSKL+ ++ D F K+ V+AVL Sbjct: 129 GWREATKAARQALLNSAVDHGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVL 188 Query: 188 SLDRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVE 247 L + + + I + K GG++ +S G K QPK+ N KIL N Sbjct: 189 RL-KGSGNLEAIHVIKKLGGSLADSYLDEGFLLDKKIG----VNQPKRIENAKILIANTG 243 Query: 248 LELKAEK-DNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQF 306 ++ K + VRV+ I AE + + EK+ ++ + G N +++ I + Q Sbjct: 244 MDTDKIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQL 303 Query: 307 FADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNLFQ 366 F + + R+ GG I ST + LG+C L EE+ IG ++ F Sbjct: 304 FGAAGVMAIEHADFVGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVMIGEDKLIHFS 363 Query: 367 GCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRD 426 G + CT++LRG +Q++ E ERSLHDA+ ++ + +++ V GGG +EM ++ + Sbjct: 364 GVALGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDSRTVYGGGCSEMLMAHAVTQ 423 Query: 427 YSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFETE 486 + GK+ + + ++AKAL ++P + +NAG+D+ +++ +LR AHS+G+ G+ + Sbjct: 424 LASRTPGKEAVAMESYAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGKTTAGLDMKEG 483 Query: 487 NIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESAN 533 IGD + E VK L SA EA +IL VD I + Sbjct: 484 TIGDMSVLGITESFQVKRQVLLSAAEAAEVILRVDNIIKAAPRKRVP 530 >4B2T-Z nrPDB Length = 531 Score = 492 bits (1266), Expect = e-139, Method: Composition-based stats. Identities = 137/529 (25%), Positives = 263/529 (49%), Gaps = 18/529 (3%) Query: 10 IVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATI 69 + L + ++ + + NI+A +Q+ L+ LGP G+ ++V+ ++ DG + Sbjct: 4 VKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVL 63 Query: 70 LKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGY 129 L + + HP A + ++ AQD GDGTTS ++ GEL+K+A ++ EG+ +I +G+ Sbjct: 64 LHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGF 123 Query: 130 RKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSL 189 A A++ + ++ V K RE L ART++ +K+ AD + VD++L++ Sbjct: 124 EAAKEKALQFLEQVKVS----KEMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAI 179 Query: 190 DRND--LDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVE 247 + D +D ++ I ++ + ++ I G+ + + K+ + IL+ NV Sbjct: 180 KKQDEPIDLFMVEIMEMKHKSETDTSLIRGLVLDHGARHPDMK---KRVEDAYILTCNVS 236 Query: 248 LELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANI---------VLSKLP 298 LE + + N+ + E+ + +V AE + I ++++++ E + V+++ Sbjct: 237 LEYEKTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIIELKKKVCGDSDKGFVVINQKG 296 Query: 299 IGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIG 358 I + A I R +M R+ A GG ++ D+ P+ LG L E +G Sbjct: 297 IDPFSLDALAKEGIIALRRAKRRNMERLTLACGGIALNSLDDLNPDCLGHAGLVYEYTLG 356 Query: 359 SERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEM 418 E++ + C ++ TLL++G + + +++ ++ D + VK A+ + +V G GA E+ Sbjct: 357 EEKFTFIEKCNNPRSVTLLIKGPNKHTLTQIKDAIRDGLRAVKNAIDDGCVVPGAGAVEV 416 Query: 419 EVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKW 478 +++ L Y ++ G+ Q+ + AFA AL +IP+ L +N+GFD E L K++ HS+ + Sbjct: 417 AMAEALVKYKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKVQAEHSESGQL 476 Query: 479 YGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNK 527 GV T +W+ VK L+S T IL VDE + Sbjct: 477 VGVDLNTGEPMVAAEAGIWDNYCVKKQLLHSCTVIATNILLVDEIMRAG 525 >4V8R-AB nrPDB Length = 527 Score = 491 bits (1264), Expect = e-139, Method: Composition-based stats. Identities = 171/531 (32%), Positives = 284/531 (53%), Gaps = 8/531 (1%) Query: 9 TIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKT-TISNDGA 67 ++ + + + + +S +AV + +K TLGP G D L+ +++ T ++NDGA Sbjct: 2 SVQIFGDQVTEERAENARLSAFVGAIAVGDLVKSTLGPKGMDKLLQSASSNTCMVTNDGA 61 Query: 68 TILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEE-GISSHLIM 126 TILK + + +PAAK LV+IS+ QD EVGDGTTSVT+L+ EL++EA+ +++ I I+ Sbjct: 62 TILKSIPLDNPAAKVLVNISKVQDDEVGDGTTSVTVLSAELLREAEKLIDQSKIHPQTII 121 Query: 127 KGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAV 186 +GYR A + A++ + + AVD + +K+ RE L A+T +SSK++ + D F ++ +A+ Sbjct: 122 EGYRLASAAALDALTKAAVDNSHDKTMFREDLIHIAKTTLSSKILSQDKDHFAELATNAI 181 Query: 187 LSLDRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNV 246 L L + + + I I KI GG + +S G K F QPK+ N KIL N Sbjct: 182 LRL-KGSTNLEHIQIIKILGGKLSDSFLDEGFILAKKFGN----NQPKRIENAKILIANT 236 Query: 247 ELELKAEK-DNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQ 305 L+ K + +V+ + AE + + K+ ++ + G N +++ I D Q Sbjct: 237 TLDTDKVKIFGTKFKVDSTAKLAQLEKAEREKMKNKIAKISKFGINTFINRQLIYDYPEQ 296 Query: 306 FFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNLF 365 F D I + + R+ GG + ST + LG C + EE+ +G + + F Sbjct: 297 LFTDLGINSIEHADFEGVERLALVTGGEVVSTFDEPSKCKLGECDVIEEIMLGEQPFLKF 356 Query: 366 QGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLR 425 GC + CT++LRG +Q + E ERSLHDA+ ++ + + V GGG EM +SK + Sbjct: 357 SGCKAGEACTIVLRGATDQTLDEAERSLHDALSVLSQTTKETRTVLGGGCAEMVMSKAVD 416 Query: 426 DYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFET 485 ++ I GK+ + + AFA+AL +P L +NAGFD+ E+++KLR + G G+ Sbjct: 417 TEAQNIDGKKSLAVEAFARALRQLPTILADNAGFDSSELVSKLRSSIYNGISTSGLDLNN 476 Query: 486 ENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESANAGM 536 I D + E +K ++SA+EA ++L VD I + + M Sbjct: 477 GTIADMRQLGIVESYKLKRAVVSSASEAAEVLLRVDNIIRARPRTANRQHM 527 >4B2T-Q nrPDB Length = 548 Score = 483 bits (1244), Expect = e-137, Method: Composition-based stats. Identities = 154/539 (28%), Positives = 257/539 (47%), Gaps = 17/539 (3%) Query: 9 TIVVLKEGTDASQG-KGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGA 67 +LKEG G + + NI AC + + + GP G + +++ +K ++ND A Sbjct: 11 FAQMLKEGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHLEKLFVTNDAA 70 Query: 68 TILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMK 127 TIL+ L+V HPAAK +V S Q+ EVGDGT V + AG L++ A+ L G+S +++ Sbjct: 71 TILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLRLGLSVSEVIE 130 Query: 128 GYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVL 187 GY A A E + +L E+ + MS + + N F K+ A + Sbjct: 131 GYEIACKKAHEILPDLVCCSAKNLRDVDEVSSLLHTSVMSKQ--YGNEVFLAKLIAQACV 188 Query: 188 SL--DRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLN 245 S+ D + I + KI G + S ++G+ FKK E + KI + Sbjct: 189 SIFPDSGHFNVDNIRVCKILGSGVHSSSVLHGMVFKKET-----EGDVTSVKDAKIAVYS 243 Query: 246 VELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQ 305 + + V ++ E+ E L+ +++ + +TGAN+V++ + D+A Sbjct: 244 CPFDGMITETKGTVLIKSAEELMNFSKGEENLMDAQVKAIADTGANVVVTGGRVADMALH 303 Query: 306 FFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNLF 365 + NI S D+ R+ + VG + + E +G C ++G + +F Sbjct: 304 YANKYNIMLVRLNSKWDLRRLCKTVGATALPRLNPPVLEEMGHCDSVYLSEVGDTQVVVF 363 Query: 366 QGCPQ-AKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCL 424 + + T++LRG + ++ ++ER++ D + K ++K +V GGGATE+E++K + Sbjct: 364 KHEKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELAKQI 423 Query: 425 RDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFE 484 Y +T G +Q I FA+A E IPR L EN+G A E+++KL H +G K G+ E Sbjct: 424 TSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGLDIE 483 Query: 485 TE--NIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESANAGMMPPQG 541 E + D V + L K A+ AT A +L VD+ I K + G PP G Sbjct: 484 AEVPAVKDMLEAGVLDTYLGKYWAIKLATNAAVTVLRVDQIIMAKPA----GGPKPPSG 538 >5GW4-d nrPDB Length = 528 Score = 473 bits (1217), Expect = e-133, Method: Composition-based stats. Identities = 149/517 (28%), Positives = 263/517 (50%), Gaps = 16/517 (3%) Query: 18 DASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVH 77 + + + +NI A +V +A++ +LGP G D +I TS + ISNDG TILK + ++H Sbjct: 13 NKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILH 72 Query: 78 PAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAV 137 P A+ LV++S AQD+E GDGTTSV IL G L+ A+ L +GI +I ++ A +V Sbjct: 73 PVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSV 132 Query: 138 EKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSL---DRNDL 194 + + E+ ++ RE L R A T++SSK++ + F + VD+VL + + ++ Sbjct: 133 DILLEMCHKVSLSD---REQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKNV 189 Query: 195 DDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELELKAEK 254 D I + K GG ++++ I+GV +T P + KI + ++ Sbjct: 190 DLNDIRLVKKVGGTIDDTEMIDGVVLTQTAI--KSAGGPTRKEKAKIGLIQFQISPPKPD 247 Query: 255 DNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPI-----GDLATQFFAD 309 + V I+ E + +++++ N++L + I DLA F + Sbjct: 248 TENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSK 307 Query: 310 RNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNLFQGCP 369 NI + +++ + + +G + + LG+ L EE+ + G Sbjct: 308 LNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIR 367 Query: 370 Q---AKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRD 426 T ++++RG +I E ERSLHDA+ +++ ++ + ++AGGGA E+E+S+ L Sbjct: 368 NNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSK 427 Query: 427 YSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFETE 486 ++++ G Q I FA ALEVIP L ENAG ++I+++ +LR H GE G+ Sbjct: 428 EARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRS 487 Query: 487 NIGDNFAKFVWEPALVKINALNSATEATNLILSVDET 523 + + + + +P LV +A+ A+E IL +D+ Sbjct: 488 GTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDI 524 >5GW5-q nrPDB Length = 568 Score = 469 bits (1207), Expect = e-132, Method: Composition-based stats. Identities = 153/564 (27%), Positives = 271/564 (48%), Gaps = 32/564 (5%) Query: 6 QTPTIVVLKEGTDA-SQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISN 64 Q P + K+G ++ S GQII +I A + + ++GP G + +IV K I+N Sbjct: 7 QNPNAGLFKQGYNSYSNADGQIIKSIAAIRELHQMCLTSMGPCGRNKIIVNHLGKIIITN 66 Query: 65 DGATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHL 124 D AT+L+ LD+VHPA K LV + Q ++GDGT V ILAGEL+ ++ + G+S+ Sbjct: 67 DAATMLRELDIVHPAVKVLVMATEQQKIDMGDGTNLVMILAGELLNVSEKLISMGLSAVE 126 Query: 125 IMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVD 184 I++GY A +++++E+ V ++K+ ELL + + +SSK + + D ++ + Sbjct: 127 IIQGYNMARKFTLKELDEMVVGEITDKNDKNELL-KMIKPVISSKK-YGSEDILSELVSE 184 Query: 185 AVLSL--------DRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKF 236 AV + + + I + KI GG++ S I G+ F + G + + Sbjct: 185 AVSHVLPVAQQAGEIPYFNVDSIRVVKIMGGSLSNSTVIKGMVFNREP--EGHVKSLSED 242 Query: 237 NNPKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSK 296 K+ L++ + V + + ++ E + I ++++ + G +++ Sbjct: 243 KKHKVAVFTCPLDIANTETKGTVLLHNAQEMLDFSKGEEKQIDAMMKEIADMGVECIVAG 302 Query: 297 LPIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQ 356 +G+LA + I S ++ R+ + G + PE LG + M+ Sbjct: 303 AGVGELALHYLNRYGILVLKVPSKFELRRLCRVCGATPLPRLGAPTPEELGLVETVKTME 362 Query: 357 IGSERYNLF--QGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQN--KLIVAG 412 IG +R +F + ++T T++LRG + + ++ER++ D + VK ++ ++ G Sbjct: 363 IGGDRVTVFKQEQGEISRTSTIILRGATQNNLDDIERAIDDGVAAVKGLMKPSGGKLLPG 422 Query: 413 GGATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAH 472 GATE+E+ + Y + G Q+ I FA A EV+PR L E AG D E+L L AH Sbjct: 423 AGATEIELISRITKYGERTPGLLQLAIKQFAVAFEVVPRTLAETAGLDVNEVLPNLYAAH 482 Query: 473 SKGEK--------WYGVVFET---ENIGDNFAKFVWEPALVKINALNSATEATNLILSVD 521 + E + GV + E + D + +++ K A+N ATEA +LS+D Sbjct: 483 NVTEPGAVKTDHLYKGVDIDGESDEGVKDIREENIYDMLATKKFAINVATEAATTVLSID 542 Query: 522 ETITNKGSESANAGMMPPQGAGRG 545 + I K + G PQG G Sbjct: 543 QIIMAKKA----GGPRAPQGPRPG 562 >5GW5-z nrPDB Length = 546 Score = 459 bits (1181), Expect = e-129, Method: Composition-based stats. Identities = 136/539 (25%), Positives = 257/539 (47%), Gaps = 25/539 (4%) Query: 12 VLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILK 71 +L ++ + + N+ + +Q L+ LGP G+ ++V ++ DG +L Sbjct: 5 LLNPKAESLRRDAALKVNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLT 64 Query: 72 LLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRK 131 + + P A + + AQD GDGTT+V L GEL+++A F++EG+ +I G+ Sbjct: 65 EMQIQSPTAVLIARAAAAQDEITGDGTTTVVCLVGELLRQAHRFIQEGVHPRIITDGFEI 124 Query: 132 AVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSL-- 189 A +++ ++E + T S+ RE L + AR+++ +K+ + + + DAVLS+ Sbjct: 125 ARKESMKFLDEFKISKT-NLSNDREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYD 183 Query: 190 -DRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVEL 248 ++LD ++ I ++ + +++ FI G+ + P + N +L LNV L Sbjct: 184 AQADNLDLHMVEIMQMQHLSPKDTTFIKGLVLDHGGRHPDM---PTRVKNAYVLILNVSL 240 Query: 249 ELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGAN----------IVLSKLP 298 E + + N+ + + +E + + KL+++ + +++++ Sbjct: 241 EYEKTEVNSGFFYSSADQRDKLAASERKFVDAKLKKIIDLKNEVCGMDPDKGFVIINQKG 300 Query: 299 IGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIG 358 I ++ FA NI R +M R+ GG Q++ D+ P+ LG L + IG Sbjct: 301 IDPMSLDVFAKHNILALRRAKRRNMERLQLVTGGEAQNSVEDLSPQILGFSGLVYQETIG 360 Query: 359 SERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEM 418 E++ K+CT+L++G +A+ + ++ D + V L++K I+ G GA + Sbjct: 361 EEKFTYVTENTDPKSCTILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGAGAFYI 420 Query: 419 EVSKCLRDYSKT---IAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILN----KLRLA 471 +S+ LR + GK + I AFA+AL VIP+ L +N+GFD +++L +L A Sbjct: 421 ALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDELDDA 480 Query: 472 HSKGEKWY-GVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGS 529 E Y GV + D + +W+ V NA+ AT + +L DE + S Sbjct: 481 QDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRS 539 >5X9V-A nrPDB Length = 521 Score = 392 bits (1006), Expect = e-109, Method: Composition-based stats. Identities = 138/536 (25%), Positives = 242/536 (45%), Gaps = 25/536 (4%) Query: 14 KEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLL 73 + + + + SN A A+ + + +LGP G D ++V + ++NDG TIL L+ Sbjct: 5 NQTQEIEERYQALFSNAAAVKALTQVVANSLGPKGLDAMLVDRFGEVVVTNDGVTILTLM 64 Query: 74 DVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAV 133 D HPAA+ +V+++RAQ+ EVGDGTT+ +LAG L+ E + +G+ ++ G +A+ Sbjct: 65 DAQHPAARMVVNMARAQEREVGDGTTTAAVLAGALVSEGVNQILKGVPVSKVLAGMNRAL 124 Query: 134 SLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSLDRND 193 + A+ I + A+ + S R ++K+ + + DA L+ Sbjct: 125 NHALFLIRKNAIKVGSITDD---------RLLAAAKIAGRGDERVAAILRDAAAMLEDKL 175 Query: 194 LD--DKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELELK 251 D KL + GA ++ I GV K +E+ +K ++L L+ L + Sbjct: 176 QDPGFKLADLVLAKVGA--DTTLIPGVVINK---SPLWEEGSQKLQEVRLLVLDDGLYPE 230 Query: 252 AEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRN 311 ++ A E Y ++ E L++++E G ++L I D+A +F + Sbjct: 231 EVEEEALASEAGFEQYLK----NQKIFQENLKKLKELGVKLILLTRGISDIAEEFCYENE 286 Query: 312 IFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSER---YNLFQGC 368 I R++ ++ RV++ G TS KP L + + + +G Sbjct: 287 IMVITRITQKELKRVLEFTGARAAKRTSLNKPVEELQKMLGYARTCFYDSRLDFTIIEGG 346 Query: 369 PQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYS 428 T T+L+ ++V+ E ER DA A ++ ++ GGGA + +S+ + Sbjct: 347 AGKATATVLIGAATDEVVDEQERIAKDAAGSFAAAYRSG-VLPGGGAFFLYLSREVESLK 405 Query: 429 KTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKL-RLAHSKGEKWYGVVFETEN 487 + G + + AF++AL+V R + ENAGF+ +E L L L K G+ FET Sbjct: 406 NRLPGMESYGVMAFSEALKVPFRVMAENAGFNGLEKLGDLMTLQVQKNNYALGLDFETGE 465 Query: 488 IGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESANAGMMPPQGAG 543 D A V +PA V A+ +A+E +L ++ I K E G G Sbjct: 466 FIDMIAGGVVDPAEVVYQAVKNASEVAISLLKINTIIKMKDYEVLKEGEQEDGGKR 521 >4V4O-A nrPDB Length = 543 Score = 319 bits (818), Expect = 2e-87, Method: Composition-based stats. Identities = 122/567 (21%), Positives = 210/567 (37%), Gaps = 77/567 (13%) Query: 20 SQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVH-- 77 + + +NA V A+K TLGP G ++++ TI+ DG T+ K +++ Sbjct: 9 EAARRALERGVNA---VANAVKVTLGPRGRNVVLEKKFGSPTITKDGVTVAKEVELEDHL 65 Query: 78 --PAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSL 135 A+ L +++ + GDGTT+ T+LA +++E + G + + +G KAV Sbjct: 66 ENIGAQLLKEVASKTNDVAGDGTTTATVLAQAIVREGLKNVAAGANPLALKRGIEKAVEA 125 Query: 136 AVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSLDRNDLD 195 AVEKI LA+ + K+ E+ A KLI D K+ + +++++ + Sbjct: 126 AVEKIKALAIPVEDRKAI-EEVATISANDPEVGKLIA---DAMEKVGKEGIITVEESKSL 181 Query: 196 DKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELELKAEKD 255 + E F+ G F K + F P+ L L EK Sbjct: 182 E-------------TELKFVEGYQFDKGYISPYFVTNPETME----AVLEDAFILIVEKK 224 Query: 256 NAEVRVEHV----------------EDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPI 299 + VR ED + +A L+ KLR A + Sbjct: 225 VSNVRELLPILEQVAQTGKPLLIIAEDVEG--EALATLVVNKLRGTLSVAA---VKAPGF 279 Query: 300 GDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTT-------------------SD 340 GD + D G V ++++ ++ S+ D Sbjct: 280 GDRRKEMLKDIAAVTGGTVISEELGFKLENATLSMLGRAERVRITKDETTIVGGKGKKED 339 Query: 341 IKPEHLGTCALFEEMQIGSERYNLFQGCPQAKTCTLLLR--GGAEQVIAEVERSLHDAIM 398 I+ G E R L + + ++R E + E + DA+ Sbjct: 340 IEARINGIKKELETTDSEYAREKLQERLAKLAGGVAVIRVGAATETELKEKKHRFEDALN 399 Query: 399 IVKRALQNKLIVAGGGATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAG 458 + A++ IV GGG T + + + K + G + +ALE RQ+ ENAG Sbjct: 400 ATRAAVEEG-IVPGGGVTLLRAISAVEELIKKLEGDEATGAKIVRRALEEPARQIAENAG 458 Query: 459 FDAIEILNKLRLAHSKGEKWYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLIL 518 ++ I+ ++ YG T D + +PA V +AL +A LIL Sbjct: 459 YEGSVIVQQILA--ETKNPRYGFNAATGEFVDMVEAGIVDPAKVTRSALQNAASIGALIL 516 Query: 519 SVDETITNKGSESANAGMMPPQGAGRG 545 + + + K + + P AG G Sbjct: 517 TTEAVVAEKPEKKEST----PASAGAG 539 >1IOK-A nrPDB Length = 545 Score = 310 bits (795), Expect = 7e-85, Method: Composition-based stats. Identities = 119/558 (21%), Positives = 220/558 (39%), Gaps = 78/558 (13%) Query: 20 SQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVHP- 78 S + +++ +N + +A+K TLGP G +++I S I+ DG ++ K +++ Sbjct: 10 SDARDRMLKGVNI---LADAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEIELSDKF 66 Query: 79 ---AAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSL 135 A+ + +++ + E GDGTT+ T+LA +++E + G++ + +G A + Sbjct: 67 ENMGAQMVREVASRTNDEAGDGTTTATVLAQAIVREGLKAVAAGMNPMDLKRGIDVATAK 126 Query: 136 AVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSLDRNDLD 195 VE I A + + A + N F + +A+ + + Sbjct: 127 VVEAIKSAARPVND-----------SSEVAQVGTISANGESFIGQQIAEAMQRVG----N 171 Query: 196 DKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKK----FNNPKILSLN---VEL 248 + +I +++ G E + G+ F + + F K + IL L Sbjct: 172 EGVITVEENKGME-TEVEVVEGMQFDRGYLSPYFVTNADKMIAELEDAYILLHEKKLSSL 230 Query: 249 ELKAEKDNAEVRVEHV-----EDYQAIVDAEWQLIFEKLRQVEETGANIVLSKL-PIGDL 302 + + ++ + ED + +A L+ KLR G I K GD Sbjct: 231 QPMVPLLESVIQSQKPLLIVAEDVEG--EALATLVVNKLRG----GLKIAAVKAPGFGDR 284 Query: 303 ATQFFADRNIFCAGRVSADDMN------------------------RVIQAVG--GSIQS 336 D I G+V ++D+ ++ G I++ Sbjct: 285 RKAMLQDIAILTGGQVISEDLGMKLENVTIDMLGRAKKVSINKDNTTIVDGAGEKAEIEA 344 Query: 337 TTSDIKPEHLGTCALFEEMQIGSERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDA 396 S I+ + T + ++ ++ ER G + + G E + E + + DA Sbjct: 345 RVSQIRQQIEETTSDYDREKL-QERVAKLAGG----VAVIRVGGMTEIEVKERKDRVDDA 399 Query: 397 IMIVKRALQNKLIVAGGGATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCEN 456 + + A+Q ++V GGG ++ +K L S + Q I +ALE RQ+ EN Sbjct: 400 LNATRAAVQEGIVV-GGGVALVQGAKVLEGLSGANS-DQDAGIAIIRRALEAPMRQIAEN 457 Query: 457 AGFDAIEILNKLRLAHSKGEKWYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNL 516 AG D + K+R +K +G +TE GD F V +PA V AL A L Sbjct: 458 AGVDGAVVAGKVR---ESSDKAFGFNAQTEEYGDMFKFGVIDPAKVVRTALEDAASVAGL 514 Query: 517 ILSVDETITNKGSESANA 534 +++ + I K A A Sbjct: 515 LITTEAMIAEKPEPKAPA 532 >5CDI-A nrPDB Length = 552 Score = 289 bits (739), Expect = 2e-78, Method: Composition-based stats. Identities = 93/553 (16%), Positives = 215/553 (38%), Gaps = 62/553 (11%) Query: 24 GQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVHP----A 79 + + + T+GP G ++++ + I NDG TI + +++ P Sbjct: 12 QALKRMQAGVDKLATVVGVTIGPKGRNVVLESKFGAPKIVNDGVTIAREVELSDPVENIG 71 Query: 80 AKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAVEK 139 A + + + GDGTT+ T+L+ + E + G + +++G K V V++ Sbjct: 72 ATLVRQAAARTNDTAGDGTTTATVLSAAFIAEGMKIVSAGTNPVQLVRGMEKTVQELVKE 131 Query: 140 INELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSLDRNDLDDKLI 199 + +++ + ++K C ++ + +D K+ V++++ + + Sbjct: 132 LRKMSSVVQTDKDLAN---VACVSAGGNTDIGSLISDAMAKVGRTGVVTMEEGKTAEDQL 188 Query: 200 GIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPKK----FNNPKILSLNVELELKAEKD 255 +F+ G+ F++ ++ F P++ + N KIL ++ ++ +D Sbjct: 189 -------------VFVEGMQFERGYTSPYFVTDPERMICEYENCKILLVD--KKISTARD 233 Query: 256 NAEVRVEHVE-DYQAIVDAEW-------QLIFEKLRQVEETGANIVLSKLPIGDLATQFF 307 + + +Y ++ AE L+ KLR + + + G+ + + Sbjct: 234 IITILESAIRGNYPLLIMAEEVEQEALATLVVNKLRGTLKV---VAIKAPGFGERRSSYL 290 Query: 308 ADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFE-------------- 353 D I G V D+M ++ ++ T + I T + + Sbjct: 291 EDIAILTGGTVVRDEMGVSLEQATDAVLGTAAKITITKERTTVVGDGSTAADVAARVKQI 350 Query: 354 -----EMQIGSERYNLFQGCPQAKTCTLLLRGG--AEQVIAEVERSLHDAIMIVKRALQN 406 + ER L + + +++ G E + E + + DA+ + A++ Sbjct: 351 RNLQMQTDQDYEREKLQERIARLSGGVAIIQVGAQTETELKEKKLRVEDALNATRAAVEE 410 Query: 407 KLIVAGGGATEMEVSKCLRDYSKTIAG-KQQMIINAFAKALEVIPRQLCENAGFDAIEIL 465 +V GGG T + +S+ + + + +QQM + +AL + + +NAG + ++ Sbjct: 411 G-VVPGGGCTLLRLSEKVDVIKRRMTDPEQQMGADIIKRALCYPIKLIAQNAGVNGSVVM 469 Query: 466 NKLRLAHSKGEKWYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETIT 525 N++ + YG T++ + + +P+ V ++ +A L D +T Sbjct: 470 NEV--MKNLDRPHYGYNAATDSFENLMETGIIDPSKVVRCSMENAVSVAKTFLLADVVVT 527 Query: 526 NKGSESANAGMMP 538 A A P Sbjct: 528 ELKEIEAGAKPNP 540 >5DA8-A nrPDB Length = 545 Score = 273 bits (698), Expect = 1e-73, Method: Composition-based stats. Identities = 106/539 (19%), Positives = 212/539 (39%), Gaps = 71/539 (13%) Query: 36 VQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVHP----AAKTLVDISRAQD 91 + A+K TLGP G ++LI T + DG T+ K +++V P A+ + +++ Sbjct: 23 LANAVKVTLGPAGRNVLIDKKFGAPTSTKDGVTVAKEIELVDPVENMGAQMVREVASKTS 82 Query: 92 AEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAVEKINELAVDITSEK 151 GDGTT+ T+LA + +E + G + +G +AV V ++ ++ I+ +K Sbjct: 83 DVAGDGTTTATVLAQAIYREGLKNVTAGARPIDLKRGIDRAVKEVVAELRNISRSISGKK 142 Query: 152 SSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSLDRNDLDDKLIGIKKIPGGAMEE 211 A + NN ++ +A+ + ++ + I +++ G E Sbjct: 143 EI-----------AQVGTISANNDPEIGELIAEAMDKVGKDGV----ITVEEAKGME-TE 186 Query: 212 SLFINGVAFKKTFSYAGFEQQPKKFNNP--KILSLNVELELKAEKDNAEVRVEHVEDYQA 269 + G+ F + + F + + L L + ++ K+ + + + + Sbjct: 187 LKVVEGMQFDRGYLSPYFVTNSETMEAELDEALILIHDKKISNMKELLPILEKAAQSGRP 246 Query: 270 IV--------DAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRVSAD 321 ++ +A L+ KLR + A + GD D I G V ++ Sbjct: 247 LLIIAEDIEGEALATLVVNKLRGTLKVAA---VKAPGFGDRRKAMLEDIAILTGGTVISE 303 Query: 322 DMN-RVIQAVGG-------------------------SIQSTTSDIKPEHLGTCALFEEM 355 + ++ A I++ ++IK + + + ++ Sbjct: 304 EKGYKLENATMAYLGQAARITIDKDNTTIVEGKGKQEEIKARINEIKGQIEKSTSDYDTE 363 Query: 356 QIGSERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGA 415 ++ ER G L + E + E + + DA+ + A+Q ++V GGG Sbjct: 364 KL-QERLAKLSGG----VAVLKIGASTEVEMKEKKARVEDALHATRAAVQEGIVV-GGGV 417 Query: 416 TEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAG-FDAIEILNKLRLAHSK 474 + +K L + Q+ I +ALE RQ+ N G D +L K++ A Sbjct: 418 ALIRAAKGLAK-AVADNEDQKTGIEIIRRALEEPLRQIVANTGTTDGAVVLEKVKNA--- 473 Query: 475 GEKWYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESAN 533 E YG TE + V +P V +AL +A +++L+ + IT+ + A+ Sbjct: 474 -EGDYGFNARTEQYENLIEAGVVDPTKVTRSALENAASVASILLTTEAAITDVKEDKAD 531 >1SJP-A nrPDB Length = 504 Score = 273 bits (698), Expect = 1e-73, Method: Composition-based stats. Identities = 98/522 (18%), Positives = 204/522 (39%), Gaps = 76/522 (14%) Query: 57 NQKTTISNDGATILKLLDVVHP----AAKTLVDISRAQDAEVGDGTTSVTILAGELMKEA 112 TI+NDG +I K +++ P A+ + ++++ D GDGTT+ T+LA L++E Sbjct: 1 WGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREG 60 Query: 113 KPFLEEGISSHLIMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIH 172 + G + + +G KAV E + + A ++ + ++ A +A + Sbjct: 61 LRNVAAGANPLGLKRGIEKAVEKVTETLLKGAKEV----ETKEQIAATAAISAGDQSIGD 116 Query: 173 NNADFFVKMCVDAVLSLDRNDLDDKLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQ 232 A+ K+ + V++++ ++ + G+ F K + F Sbjct: 117 LIAEAMDKVGNEGVITVEESNTFGLQL-------------ELTEGMRFDKGYISGYFVTD 163 Query: 233 PKK----FNNPKILSLNVELE--------LKAEKDNAEVRVEHVEDYQAIVDAEWQLIFE 280 P++ +P IL ++ ++ L+ + + ED + +A L+ Sbjct: 164 PERQEAVLEDPYILLVSSKVSTVKDLLPLLEKVIGAGKPLLIIAEDVEG--EALSTLVVN 221 Query: 281 KLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRVSADDMN---------------- 324 K+R T ++ + GD D I G+V ++++ Sbjct: 222 KIRG---TFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISEEVGLTLENADLSLLGKARK 278 Query: 325 --------RVIQAVGGS--IQSTTSDIKPEHLGTCALFEEMQIGSERYNLFQGCPQAKTC 374 +++ G + I + I+ E + + ++ ++ ER G Sbjct: 279 VVVTKDETTIVEGAGDTDAIAGRVAQIRQEIENSDSDYDREKL-QERLAKLAGG----VA 333 Query: 375 TLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYSKTIAGK 434 + E + E + + DA+ K A++ IVAGGG T ++ + L + + G Sbjct: 334 VIKAGAATEVELKERKHRIEDAVRNAKAAVEEG-IVAGGGVTLLQAAPTLDELK--LEGD 390 Query: 435 QQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFETENIGDNFAK 494 + N ALE +Q+ N+G + + K+R + +G+ +T D A Sbjct: 391 EATGANIVKVALEAPLKQIAFNSGLEPGVVAEKVRNLPA----GHGLNAQTGVYEDLLAA 446 Query: 495 FVWEPALVKINALNSATEATNLILSVDETITNKGSESANAGM 536 V +P V +AL +A L L+ + + +K + + Sbjct: 447 GVADPVKVTRSALQNAASIAGLFLTTEAVVADKPEKEKASVP 488 >4AAR-A nrPDB Length = 548 Score = 271 bits (694), Expect = 5e-73, Method: Composition-based stats. Identities = 105/553 (18%), Positives = 217/553 (39%), Gaps = 74/553 (13%) Query: 22 GKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVHP--- 78 G + + + +A+K TLGP G ++++ S TI+ DG ++ + +++ Sbjct: 9 GNDARVKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFEN 68 Query: 79 -AAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAV 137 A+ + +++ + GDGTT+ T+LA ++ E + G++ + +G KAV+ AV Sbjct: 69 MGAQMVKEVASKANDAAGDGTTTATVLAQAIITEGLKAVAAGMNPMDLKRGIDKAVTAAV 128 Query: 138 EKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSLDRNDLDDK 197 E++ L+V + K+ + KLI + K+ + V++++ Sbjct: 129 EELKALSVPCSDSKAIAQVGTISANSDETVGKLIA---EAMDKVGKEGVITVEDGT---- 181 Query: 198 LIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQPK----KFNNPKILSLNVELE---- 249 G +E + G+ F + + F +P+ + +P IL + ++ Sbjct: 182 ---------GLQDELDVVEGMQFDRGYLSPYFINKPETGAVELESPFILLADKKISNIRE 232 Query: 250 ----LKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQ 305 L+A + + ED + +A L+ +R + + A + GD Sbjct: 233 MLPVLEAVAKAGKPLLIIAEDVEG--EALATLVVNTMRGIVKVAA---VKAPGFGDRRKA 287 Query: 306 FFADRNIFCAGRVSADDMN------------------------RVIQAVG--GSIQSTTS 339 D G V ++++ +I VG +IQ + Sbjct: 288 MLQDIATLTGGTVISEEIGMELEKATLEDLGQAKRVVINKDTTTIIDGVGEEAAIQGRVA 347 Query: 340 DIKPEHLGTCALFEEMQIGSERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMI 399 I+ + + ++ ++ ER G + + E + E + + A+ Sbjct: 348 QIRQQIEEATSDYDREKL-QERVAKLAGG----VAVIKVGAATEVEMKEKKARVEAALHA 402 Query: 400 VKRALQNKLIVAGGGATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGF 459 + A++ +VAGGG + V+ L D Q + I +A+E RQ+ N G Sbjct: 403 TRAAVEEG-VVAGGGVALIRVASKLADLRGQNE-DQNVGIKVALRAMEAPLRQIVLNCGE 460 Query: 460 DAIEILNKLRLAHSKGEKWYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILS 519 + + N ++ G+ YG TE G+ + +P V +AL A L+++ Sbjct: 461 EPSVVANTVKG----GDGNYGYNAATEEYGNMIDMGILDPTKVTRSALQYAASVAGLMIT 516 Query: 520 VDETITNKGSESA 532 + +T+ A Sbjct: 517 TECMVTDLPKNDA 529 >4PJ1-A nrPDB Length = 558 Score = 254 bits (649), Expect = 7e-68, Method: Composition-based stats. Identities = 102/560 (18%), Positives = 202/560 (36%), Gaps = 83/560 (14%) Query: 22 GKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQKTTISNDGATILKLLDVVHP--- 78 G + + +A+ T+GP G ++I S ++ DG T+ K +D+ Sbjct: 35 GADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKN 94 Query: 79 -AAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAV 137 AK + D++ + E GDGTT+ T+LA + KE + +G + I +G AV + Sbjct: 95 IGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVI 154 Query: 138 EKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFVKMCVDAVLSLDRNDLDDK 197 ++ + + +T+ + A + + N + DA+ + R + Sbjct: 155 AELKKQSKPVTTPEEI-----------AQVATISANGDKEIGNIISDAMKKVGRKGV--- 200 Query: 198 LIGIKKIPGGAMEES-LFINGVAFKKTFSYAGFEQQPK----KFNNPKILS--------- 243 I G + + I G+ F + + F K +F + +L Sbjct: 201 ---ITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQ 257 Query: 244 -LNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKL-PIGD 301 + LE+ V + ED +A L+ +L+ G +V K GD Sbjct: 258 SIVPALEIANAHRKPLVII--AEDVDG--EALSTLVLNRLK----VGLQVVAVKAPGFGD 309 Query: 302 LATQFFADRNIFCAGRVSAD-------------DMNRVIQAV--------------GGSI 334 D I G V + D+ +V + + I Sbjct: 310 NRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGKVIVTKDDAMLLKGKGDKAQI 369 Query: 335 QSTTSDIKPEHLGTCALFEEMQIGSERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLH 394 + +I + T + +E+ ++ +ER L + G ++ + E + + Sbjct: 370 EKRIQEIIEQLDVTTSEYEKEKL-NERLAKLSDG----VAVLKVGGTSDVEVNEKKDRVT 424 Query: 395 DAIMIVKRALQNKLIVAGGGATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLC 454 DA+ + A++ IV GGG + L + Q++ I + L++ + Sbjct: 425 DALNATRAAVEEG-IVLGGGCALLRCIPALDSLTPANE-DQKIGIEIIKRTLKIPAMTIA 482 Query: 455 ENAGFDAIEILNKLRLAHSKGEKWYGVVFETENIGDNFAKFVWEPALVKINALNSATEAT 514 +NAG + I+ K+ + G + + K + +P V AL A Sbjct: 483 KNAGVEGSLIVEKI----MQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVA 538 Query: 515 NLILSVDETITNKGSESANA 534 +L+ + + +T E + Sbjct: 539 SLLTTAEVVVTEIPKEEKDP 558 >1GN1-A nrPDB Length = 178 Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 48/175 (27%), Positives = 84/175 (48%), Gaps = 4/175 (2%) Query: 209 MEESLFINGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELELKAEKDNAEVRVEHVEDYQ 268 ME+S + GV K ++ + NP+I+ L+ LE K + ++ + ED+ Sbjct: 1 MEDSCVLRGVMINKDVTHPRMR---RYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFT 57 Query: 269 AIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRVSADDMNRVIQ 328 I+ E + I + + + ++V+++ I DLA + N+ RV D NR+ + Sbjct: 58 RILQMEEEYIHQLCEDIIQLKPDVVITEKGISDLAQHYLMRANVTAIRRVRKTDNNRIAR 117 Query: 329 AVGGSIQSTTSDIKPEHLGT-CALFEEMQIGSERYNLFQGCPQAKTCTLLLRGGA 382 A G I S +++ + +GT L E +IG E + C K CT+LLRG + Sbjct: 118 ACGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGAS 172 >1E0R-B nrPDB Length = 159 Score = 166 bits (420), Expect = 3e-41, Method: Composition-based stats. Identities = 41/156 (26%), Positives = 76/156 (48%), Gaps = 3/156 (1%) Query: 215 INGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAE 274 +NG+ K + G P + KI L+ LE+K + + +R+E Q + E Sbjct: 1 MNGIIVDKEKVHPGM---PDVVKDAKIALLDAPLEIKKPEFDTNLRIEDPSMIQKFLAQE 57 Query: 275 WQLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSI 334 ++ E + +++ GAN+V+++ I D+A + + I+ RV DM+++ +A G SI Sbjct: 58 ENMLREMVDKIKSVGANVVITQKGIDDMAQHYLSRAGIYAVRRVKKSDMDKLAKATGASI 117 Query: 335 QSTTSDIKPEHLGTCALFEEMQIGSERYNLFQGCPQ 370 ST +I LGT E++++G + G Sbjct: 118 VSTIDEISSSDLGTAERVEQVKVGEDYMTFVTGSKN 153 >1ASS-A nrPDB Length = 159 Score = 161 bits (408), Expect = 6e-40, Method: Composition-based stats. Identities = 41/156 (26%), Positives = 75/156 (48%), Gaps = 3/156 (1%) Query: 215 INGVAFKKTFSYAGFEQQPKKFNNPKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAE 274 ++G+ K ++ + P N KI ++ LE+K + A+V++ Q ++ E Sbjct: 1 MSGIVIDKEKVHS---KMPDVVKNAKIALIDSALEIKKTEIEAKVQISDPSKIQDFLNQE 57 Query: 275 WQLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSI 334 + + +++++GAN+VL + I D+A + A I+ RV DM ++ +A G I Sbjct: 58 TNTFKQMVEKIKKSGANVVLCQKGIDDVAQHYLAKEGIYAVRRVKKSDMEKLAKATGAKI 117 Query: 335 QSTTSDIKPEHLGTCALFEEMQIGSERYNLFQGCPQ 370 + D+ P LG EE +IG +R GC Sbjct: 118 VTDLDDLTPSVLGEAETVEERKIGDDRMTFVMGCKN 153 >5CDK-A nrPDB Length = 183 Score = 68.1 bits (165), Expect = 8e-12, Method: Composition-based stats. Identities = 25/147 (17%), Positives = 57/147 (38%), Gaps = 17/147 (11%) Query: 219 AFKKTFSYAGFEQQPKK----FNNPKILSLNVELELKAEKDNAEVRVEHVE-DYQAIVDA 273 F++ ++ F P++ + N KIL ++ ++ +D + + +Y ++ A Sbjct: 2 QFERGYTSPYFVTDPERMICEYENCKILLVD--KKISTARDIITILESAIRGNYPLLIMA 59 Query: 274 EW-------QLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRVSADDMNRV 326 E L+ KLR + + + G+ + + D I G V D+M Sbjct: 60 EEVEQEALATLVVNKLRGTLKV---VAIKAPGFGERRSSYLEDIAILTGGTVVRDEMGVS 116 Query: 327 IQAVGGSIQSTTSDIKPEHLGTCALFE 353 ++ ++ T + I T + + Sbjct: 117 LEQATDAVLGTAAKITITKERTTVVGD 143 >3OSX-A nrPDB Length = 201 Score = 55.4 bits (132), Expect = 6e-08, Method: Composition-based stats. Identities = 29/191 (15%), Positives = 66/191 (34%), Gaps = 44/191 (23%) Query: 216 NGVAFKKTFSYAGFEQQPK----KFNNPKILSLNVELE--------LKAEKDNAEVRVEH 263 G+ F + + F +P+ + NP IL ++ ++ L+ ++ V Sbjct: 13 EGMQFDRGYLSPYFINKPESGSVELENPYILLVDKKISNIRELLPVLEGVAKASKPLVII 72 Query: 264 VEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRVSADDM 323 ED + +A L+ +R + + + + GD D G V ++++ Sbjct: 73 AEDVEG--EALATLVVNNMRGIVKVAS---VKAPGFGDRRKAMLQDIATLTNGTVISEEI 127 Query: 324 N------------------------RVIQAVG--GSIQSTTSDIKPEHLGTCALFEEMQI 357 +I VG G+I + + I+ + + + ++ ++ Sbjct: 128 GLELEKATLEDLGQAKRVVINKDTTTIIDGVGEEGAIAARVTQIRQQIEESTSDYDREKL 187 Query: 358 GSERYNLFQGC 368 ER G Sbjct: 188 -QERVAKLAGG 197 >1KID-A nrPDB Length = 203 Score = 52.7 bits (125), Expect = 4e-07, Method: Composition-based stats. Identities = 29/191 (15%), Positives = 63/191 (32%), Gaps = 44/191 (23%) Query: 216 NGVAFKKTFSYAGFEQQPK----KFNNPKILSLNVELE--------LKAEKDNAEVRVEH 263 G+ F + + F +P+ + +P IL + ++ L+A + + Sbjct: 18 EGMQFDRGYLSPYFINKPETGAVELESPFILLADKKISNIREMLPVLEAVAKAGKPLLII 77 Query: 264 VEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRVSADDM 323 ED + +A L+ +R + + A + GD D G V ++++ Sbjct: 78 AEDVEG--EALATLVVNTMRGIVKVAA---VKAPGFGDRRKAMLQDIATLTGGTVISEEI 132 Query: 324 N------------------------RVIQAVG--GSIQSTTSDIKPEHLGTCALFEEMQI 357 +I VG +IQ + I+ + + ++ ++ Sbjct: 133 GMELEKATLEDLGQAKRVVINKDTTTIIDGVGEEAAIQGRVAQIRQQIEEATSDYDREKL 192 Query: 358 GSERYNLFQGC 368 ER G Sbjct: 193 -QERVAKLAGG 202 >1SRV-A nrPDB Length = 145 Score = 52.7 bits (125), Expect = 4e-07, Method: Composition-based stats. Identities = 26/149 (17%), Positives = 43/149 (28%), Gaps = 25/149 (16%) Query: 217 GVAFKKTFSYAGFEQQPKKFNNPKILSLNVELELKAEKDNAEVRVEHV------------ 264 G F K + F P+ L L EK + VR Sbjct: 1 GYQFDKGYISPYFVTNPETME----AVLEDAFILIVEKKVSNVRELLPILEQVAQTGKPL 56 Query: 265 ----EDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRVSA 320 ED + +A L+ KLR A + GD + D G V + Sbjct: 57 LIIAEDVEG--EALATLVVNKLRGTLSVAA---VKAPGFGDRRKEMLKDIAAVTGGTVIS 111 Query: 321 DDMNRVIQAVGGSIQSTTSDIKPEHLGTC 349 +++ ++ S+ ++ T Sbjct: 112 EELGFKLENATLSMLGRAERVRITKDETT 140 >1DKD-A nrPDB Length = 146 Score = 48.9 bits (115), Expect = 5e-06, Method: Composition-based stats. Identities = 23/153 (15%), Positives = 48/153 (31%), Gaps = 28/153 (18%) Query: 216 NGVAFKKTFSYAGFEQQPK----KFNNPKILSLNVELE--------LKAEKDNAEVRVEH 263 G+ F + + F +P+ + +P IL + ++ L+A + + Sbjct: 1 EGMQFDRGYLSPYFINKPETGAVELESPFILLADKKISNIREMLPVLEAVAKAGKPLLII 60 Query: 264 VEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRVSADDM 323 ED + +A L+ +R + + A + GD D G V ++++ Sbjct: 61 AEDVEG--EALATLVVNTMRGIVKVAA---VKAPGFGDRRKAMLQDIATLTGGTVISEEI 115 Query: 324 NRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQ 356 E LG + Sbjct: 116 GM-----------ELEKATLEDLGQAKRVVINK 137 >3M6C-A nrPDB Length = 194 Score = 46.2 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 26/139 (18%), Positives = 47/139 (33%), Gaps = 17/139 (12%) Query: 211 ESLFINGVAFKKTFSYAGFEQQPK----KFNNPKILSLNVEL--------ELKAEKDNAE 258 E F G+ F K F A F + IL ++ L+ + Sbjct: 1 ELEFTEGIGFDKGFLSAYFVTDFDNQQAVLEDALILLHQDKISSLPDLLPLLEKVAGTGK 60 Query: 259 VRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRV 318 + ED + +A L+ +R+ + + + GD F D + G+V Sbjct: 61 PLLIVAEDVEG--EALATLVVNAIRKTLKA---VAVKGPYFGDRRKAFLEDLAVVTGGQV 115 Query: 319 SADDMNRVIQAVGGSIQST 337 D V++ VG + + Sbjct: 116 VNPDAGMVLREVGLEVLGS 134 >3LXD-A nrPDB Length = 415 Score = 44.2 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 40/251 (15%), Positives = 70/251 (27%), Gaps = 38/251 (15%) Query: 301 DLATQFFADRNI---FCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEHLGTCALFEEMQI 357 L+ ++ A C + V +G + S LG + E Sbjct: 52 PLSKEYLAREKTFERICIRPAQFWEDKAVEMKLGAEVVSLDPAAHTVKLGDGSAIE---- 107 Query: 358 GSERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIVAGGGATE 417 + G + + + E + D +M A +V GGG Sbjct: 108 -YGKLIWATGGDPRRLSCVGADLAGVHAVRTKEDA--DRLMAELDAGAKNAVVIGGGYIG 164 Query: 418 MEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNKLRLAHSKGEK 477 +E + L + + LE +PR L AG E L++ A + Sbjct: 165 LEAAAVLTKFGVNVT------------LLEALPRVLARVAG----EALSEFYQAE---HR 205 Query: 478 WYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILSVDETITNKGSESANAGMM 537 +GV T D + V + + + + G + Sbjct: 206 AHGVDLRTGAAMDCIEG---DGTKVTGVRMQDGSVIPA------DIVIVGIGIVPCVGAL 256 Query: 538 PPQGAGRGRGM 548 GA G G+ Sbjct: 257 ISAGASGGNGV 267 >5CDJ-A nrPDB Length = 186 Score = 42.7 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 28/192 (14%), Positives = 60/192 (31%), Gaps = 46/192 (23%) Query: 216 NGVAFKKTFSYAGFEQQPKK----FNNPKILSLN---------VELELKAEKDNAEVRVE 262 G+ + + F ++ ++N ++L + + + + + NA + + Sbjct: 2 EGMEIDRGYISPQFVTNQERLLVEYDNCRVLVTDQKIDAIRDIIPILEQVTRLNAPLLI- 60 Query: 263 HVEDYQAIVDAEWQLIFEKLRQVEETGANIVLSKLPIGDLATQFFADRNIFCAGRVSADD 322 ED +A L+ KLR V + G+ D I A D Sbjct: 61 IAEDVSG--EALATLVVNKLRGVLNV---CAIKAPGFGERRKSLLQDIAIVTGAEFIAKD 115 Query: 323 MNRVIQ--------------------------AVGGSIQSTTSDIKPEHLGTCALFEEMQ 356 + ++ A I+ + +K E T ++++ + Sbjct: 116 LGMKVEQAVVEQLGVARKVTVANNTTTLIADAASKDEIEMRIAQLKKELAETDSVYDTEK 175 Query: 357 IGSERYNLFQGC 368 + SER G Sbjct: 176 L-SERIAKLSGG 186 >3E0V-A nrPDB Length = 539 Score = 35.0 bits (79), Expect = 0.097, Method: Composition-based stats. Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 12/76 (15%) Query: 20 SQGKGQIISN-INACVAVQEALKPTLGPLGSDILI---------VTSNQKTTISNDGATI 69 QG I ++ I + V + ++ LGP G DI+I V + +DG + Sbjct: 243 EQGVDMIFASFIRSAEQVGD-VRKALGPKGRDIMIICKIENHQGVQNIDSIIEESDGIMV 301 Query: 70 LK-LLDVVHPAAKTLV 84 + L V PA K +V Sbjct: 302 ARGDLGVEIPAEKVVV 317 >5LY3-A nrPDB Length = 432 Score = 30.4 bits (67), Expect = 2.4, Method: Composition-based stats. Identities = 15/75 (20%), Positives = 32/75 (42%), Gaps = 5/75 (6%) Query: 402 RALQNKLIVAGGGATEMEVSKC--LRDYSKTIAGKQQMIINAFAKALEVIPRQLCE---N 456 ++ L+ G E L+D + +++ + +A+ ++PR+L E Sbjct: 195 ALIREGLVALNRGGAEANAITREILKDIGYSDIAREEYAVEVVKRAVGLVPRRLKEAIRA 254 Query: 457 AGFDAIEILNKLRLA 471 A D + K+RL+ Sbjct: 255 AKSDPDRFVTKVRLS 269 >2GJN-A nrPDB Length = 328 Score = 30.0 bits (66), Expect = 2.9, Method: Composition-based stats. Identities = 15/86 (17%), Positives = 32/86 (37%), Gaps = 5/86 (5%) Query: 359 SERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNKLIV--AGGGAT 416 R+ + CP +R E+ + RSL + + + A+ +++ A GGA Sbjct: 201 GTRFLATRECPIHPAVKAAIRAADERSTDLIMRSLRNTARVARNAISQEVLAIEARGGAG 260 Query: 417 EMEVSKCLRDYSKT---IAGKQQMII 439 +++ + G + I Sbjct: 261 YADIAALVSGQRGRQVYQQGDTDLGI 286 >1Q1R-A nrPDB Length = 431 Score = 30.0 bits (66), Expect = 3.1, Method: Composition-based stats. Identities = 31/181 (17%), Positives = 63/181 (34%), Gaps = 26/181 (14%) Query: 327 IQAVGGSIQSTTSDIKPEHLGTCALFEEMQIGSERYNLFQGC---PQAKTCTLLLRGGAE 383 IQ +GG+ + + + + + L + + +R L G P + + Sbjct: 75 IQLLGGTQVTAINRDRQQVI----LSDGRALDYDRLVLATGGRPRPLPVASGAVGKANNF 130 Query: 384 QVIAEVERSLHDAIMIVKRALQNKL-IVAGGGATEMEVSKC----------LRDYSKTIA 432 + + R+L DA I ++ + + +V GGG +EV+ L ++ + Sbjct: 131 RYL----RTLEDAECIRRQLIADNRLVVIGGGYIGLEVAATAIKANMHVTLLDTAARVLE 186 Query: 433 GKQQMIINAFAKALE----VIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFETENI 488 ++AF + L V R + GF+ K+ + I Sbjct: 187 RVTAPPVSAFYEHLHREAGVDIRTGTQVCGFEMSTDQQKVTAVLCEDGTRLPADLVIAGI 246 Query: 489 G 489 G Sbjct: 247 G 247 >4KRZ-A nrPDB Length = 519 Score = 29.6 bits (65), Expect = 3.4, Method: Composition-based stats. Identities = 17/75 (22%), Positives = 31/75 (41%), Gaps = 10/75 (13%) Query: 20 SQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQK---------TTISNDGATIL 70 QG + ++ + ++ LG G DILI++ + ++DG + Sbjct: 223 EQGIDMVFASFIRTAEQVQEVREALGEKGKDILIISKIENHQGVQNIDGIIEASDGIMVA 282 Query: 71 K-LLDVVHPAAKTLV 84 + L V PA K +V Sbjct: 283 RGDLGVEIPAEKVVV 297 >3OZB-A nrPDB Length = 259 Score = 29.6 bits (65), Expect = 3.9, Method: Composition-based stats. Identities = 16/65 (24%), Positives = 28/65 (43%), Gaps = 9/65 (13%) Query: 348 TCALFEEMQIGSERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNK 407 AL E+ + L K+ ++ +AE+E++LHD I V+ L Sbjct: 204 EAALARELDLPYACLALVVNPAAGKSAGII-------TMAEIEQALHDGIGKVREVL--A 254 Query: 408 LIVAG 412 ++AG Sbjct: 255 RVLAG 259 >5NLM-A nrPDB Length = 478 Score = 29.6 bits (65), Expect = 4.0, Method: Composition-based stats. Identities = 17/78 (21%), Positives = 27/78 (34%), Gaps = 5/78 (6%) Query: 3 FGSQTPTIVVLKEGTDA----SQGKGQIISNINACVAVQEALKPTLGPLGSDILIV-TSN 57 + Q V+L EG S GK II + E ++ G + Sbjct: 393 YAEQKMNAVMLTEGLRVGLRPSVGKDGIIRGAEIARVIGELMEGEEGKRIRSKMQELKRA 452 Query: 58 QKTTISNDGATILKLLDV 75 +S DG++ L +V Sbjct: 453 ASAVLSKDGSSTRALEEV 470 >2W96-B nrPDB Length = 306 Score = 28.8 bits (63), Expect = 5.5, Method: Composition-based stats. Identities = 11/93 (11%), Positives = 24/93 (25%), Gaps = 12/93 (12%) Query: 458 GFDAIEILNKLRLAHSKGEKWYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLI 517 D + + R + Y D ++ + + L + + Sbjct: 167 ALDPVVVTLWYRAPEVLLQSTY------ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQL 220 Query: 518 LSVDETITNKGSE------SANAGMMPPQGAGR 544 + + I + S G PP+G Sbjct: 221 GKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRP 253 >4XFK-A nrPDB Length = 399 Score = 28.8 bits (63), Expect = 5.8, Method: Composition-based stats. Identities = 26/133 (19%), Positives = 50/133 (37%), Gaps = 26/133 (19%) Query: 400 VKRALQNKL--IVAGGG-ATEMEVSKCLRDYSKTIAGKQQMIINAFAKALE--------- 447 VK A+ + IV G A ++++ +R Y+ GK+ + +N A+ALE Sbjct: 71 VKAAIADGAQIIVQGSSSAVAGQITEDVRKYNLRNKGKEVLYLNLGAEALELTGSKCHFY 130 Query: 448 ---------VIPRQLCENAGFDAIEILNKLRLAHSKGEKWYGVVFETENIGDNFAKF--V 496 + + + + G IL + R +GV E + + V Sbjct: 131 HFRFSPNAAIRFKTVAQ--GMKDKGILGE-RAYSINQNYSWGVDVENTVVANAKEIGYEV 187 Query: 497 WEPALVKINALNS 509 + L ++N + Sbjct: 188 VDKTLHEVNKIQD 200 >3OZ2-A nrPDB Length = 397 Score = 28.8 bits (63), Expect = 6.1, Method: Composition-based stats. Identities = 23/146 (15%), Positives = 44/146 (30%), Gaps = 13/146 (8%) Query: 49 SDILIVTSNQ-----KTTISNDGATILK-LLDVVHPAAKTLVDISRAQDAEVGDGTTSVT 102 D I + G ++ K + + P + D +R D G G + Sbjct: 242 LDRFIENHPGLKKGQDIQLVTGGVSVSKVKMPITMPGLMLVGDAARLIDPITGGGIANAI 301 Query: 103 ILAGELMKEAKPFLEEGISSHLIMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCA 162 + + K +E S +M+ Y K I E +E L + Sbjct: 302 VSGMYAAQVTKEAIESNDYSPQMMQKYEK-------LIKERFERKHLRNWVAKEKLAMLS 354 Query: 163 RTAMSSKLIHNNADFFVKMCVDAVLS 188 + + + + V+A+L Sbjct: 355 DDTLDKLVDIVSEQVLTTISVEAILK 380 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.137 0.341 Lambda K H 0.267 0.0420 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,240,427 Number of Sequences: 36641 Number of extensions: 696379 Number of successful extensions: 2772 Number of sequences better than 10.0: 67 Number of HSP's better than 10.0 without gapping: 85 Number of HSP's successfully gapped in prelim test: 30 Number of HSP's that attempted gapping in prelim test: 2401 Number of HSP's gapped (non-prelim): 128 length of query: 550 length of database: 10,336,785 effective HSP length: 102 effective length of query: 448 effective length of database: 6,599,403 effective search space: 2956532544 effective search space used: 2956532544 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 62 (28.5 bits)