BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P42935 (788 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4XFV-A nrPDB 1631 0.0 5NZU-C nrPDB 57 4e-08 5NNZ-B nrPDB 56 7e-08 5Z56-q nrPDB 55 2e-07 6Q8F-A nrPDB 54 2e-07 4LG8-A nrPDB 54 2e-07 1VYH-C nrPDB 53 6e-07 2H9P-A nrPDB 53 6e-07 5M25-A nrPDB 52 7e-07 5XYI-g nrPDB 52 8e-07 6QX9-5O nrPDB 51 2e-06 5MZH-A nrPDB 50 3e-06 2YNP-A nrPDB 50 4e-06 3FM0-A nrPDB 50 4e-06 3DM0-A nrPDB 50 5e-06 3MKQ-A nrPDB 50 5e-06 4J0W-A nrPDB 49 6e-06 6MZM-G nrPDB 49 7e-06 6F3T-A nrPDB 49 7e-06 4V8M-A7 nrPDB 49 9e-06 5FVM-C nrPDB 49 9e-06 4YCZ-A nrPDB 48 1e-05 6EMK-B nrPDB 47 2e-05 5I2T-A nrPDB 47 3e-05 5WLC-LO nrPDB 47 3e-05 5FL8-q nrPDB 46 5e-05 5OPT-p nrPDB 45 1e-04 6GMH-W nrPDB 45 1e-04 5OQL-J nrPDB 45 2e-04 4BTS-AR nrPDB 45 2e-04 6HQA-B nrPDB 44 3e-04 5GAN-H nrPDB 44 4e-04 2HES-X nrPDB 44 4e-04 5UZ7-B nrPDB 43 7e-04 4BZK-B nrPDB 42 7e-04 5WYK-BB nrPDB 42 8e-04 3JRP-A nrPDB 42 9e-04 3JAP-g nrPDB 42 0.001 5K1B-B nrPDB 42 0.001 5K19-A nrPDB 42 0.001 6J6H-n nrPDB 42 0.001 5WYJ-BC nrPDB 40 0.003 5OQL-d nrPDB 40 0.003 5G04-R nrPDB 40 0.003 6ID0-T nrPDB 40 0.004 6N9G-C nrPDB 40 0.004 4V7E-Bg nrPDB 40 0.004 4GGA-A nrPDB 40 0.004 5LCW-Q nrPDB 40 0.004 3JRO-A nrPDB 40 0.004 4N14-A nrPDB 40 0.005 3JB9-g nrPDB 39 0.006 3ACP-A nrPDB 39 0.008 6QX9-4B nrPDB 39 0.009 6EOJ-D nrPDB 39 0.010 5WBU-D nrPDB 39 0.013 3JB9-L nrPDB 38 0.014 5WJC-A nrPDB 38 0.019 4XYI-A nrPDB 38 0.019 3ODT-A nrPDB 37 0.024 6E29-D nrPDB 37 0.026 3C9C-A nrPDB 37 0.030 3BG0-A nrPDB 37 0.037 6BX3-B nrPDB 37 0.037 5WLC-LU nrPDB 37 0.044 4L9O-A nrPDB 36 0.053 5Y88-O nrPDB 36 0.061 5Y1U-A nrPDB 36 0.067 6G51-g nrPDB 36 0.074 4U1E-I nrPDB 36 0.075 6BX3-A nrPDB 36 0.083 5CXC-A nrPDB 35 0.092 4V6W-Ag nrPDB 35 0.099 5A9Q-7 nrPDB 35 0.10 3F3P-A nrPDB 35 0.11 3CFV-B nrPDB 35 0.16 5WLC-SG nrPDB 35 0.17 6ELZ-p nrPDB 34 0.23 6HHQ-h nrPDB 34 0.24 4J0X-A nrPDB 34 0.26 5OQL-X nrPDB 33 0.35 5BJS-A nrPDB 33 0.36 6CHG-A nrPDB 32 0.72 4A11-B nrPDB 32 0.88 1NR0-A nrPDB 32 0.90 1NJ2-A nrPDB 32 1.3 3I2N-A nrPDB 32 1.3 5L9T-R nrPDB 32 1.4 5FA5-B nrPDB 32 1.4 5A31-R nrPDB 31 2.4 4AEZ-A nrPDB 31 2.4 5WLC-LL nrPDB 30 4.1 5IXM-A nrPDB 30 4.4 2ZBT-A nrPDB 30 4.7 5YZG-2 nrPDB 30 4.8 3NA6-A nrPDB 30 5.2 3DWL-C nrPDB 30 5.5 5WYJ-BE nrPDB 29 6.7 2P9P-C nrPDB 29 6.7 >4XFV-A nrPDB Length = 792 Score = 1631 bits (4223), Expect = 0.0, Method: Compositional matrix adjust. Identities = 788/788 (100%), Positives = 788/788 (100%) Query: 1 MVECITPEAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEA 60 MVECITPEAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEA Sbjct: 5 MVECITPEAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEA 64 Query: 61 EVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVG 120 EVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVG Sbjct: 65 EVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVG 124 Query: 121 CADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIA 180 CADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIA Sbjct: 125 CADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIA 184 Query: 181 SFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDL 240 SFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDL Sbjct: 185 SFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDL 244 Query: 241 IDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAAT 300 IDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAAT Sbjct: 245 IDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAAT 304 Query: 301 ADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGK 360 ADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGK Sbjct: 305 ADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGK 364 Query: 361 TGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDAS 420 TGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDAS Sbjct: 365 TGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDAS 424 Query: 421 GRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVG 480 GRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVG Sbjct: 425 GRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVG 484 Query: 481 IQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMED 540 IQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMED Sbjct: 485 IQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMED 544 Query: 541 QLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKP 600 QLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKP Sbjct: 545 QLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKP 604 Query: 601 ALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDAD 660 ALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDAD Sbjct: 605 ALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDAD 664 Query: 661 WAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILI 720 WAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILI Sbjct: 665 WAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILI 724 Query: 721 SVGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLST 780 SVGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLST Sbjct: 725 SVGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLST 784 Query: 781 RIYSLAYE 788 RIYSLAYE Sbjct: 785 RIYSLAYE 792 >5NZU-C nrPDB Length = 905 Score = 56.6 bits (135), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 29/80 (36%), Positives = 46/80 (57%), Gaps = 7/80 (8%) Query: 54 TLKGHEAEVTCVRFVPDSD--FMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALS 111 TL+GHE V C+ + D +++S ++D VKIW DY + C+QT++ +++ + S Sbjct: 180 TLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIW---DYQNKTCVQTLEGHAQNVSCAS 236 Query: 112 ALPSL--ISVGCADGTISIW 129 P L I G DGT+ IW Sbjct: 237 FHPELPIIITGSEDGTVRIW 256 Score = 46.6 bits (109), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 44/181 (24%), Positives = 77/181 (42%), Gaps = 21/181 (11%) Query: 55 LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF-TDYSHLQCIQTIQHYSKTIVALSAL 113 + H + C+ P F++++S+D +K+W + +S Q + HY IV Sbjct: 95 FEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKD 154 Query: 114 PSLISVGCADGTISIWRQNIQNDEFGL-AHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGG 172 + + D TI +W+ + F L HE + C+ +K YL++ G Sbjct: 155 NNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVN-------CIDYYSGGDKPYLIS-GA 206 Query: 173 TNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRL 232 + V I + + V LEGH V +F H E P ++ +GS+D +R+ Sbjct: 207 DDRLVKIWDY-------QNKTCVQTLEGHAQNVSCASF-HPELP---IIITGSEDGTVRI 255 Query: 233 W 233 W Sbjct: 256 W 256 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 19/56 (33%), Positives = 30/56 (53%), Gaps = 3/56 (5%) Query: 36 KTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDY 91 + + +WD NK TL+GH V+C F P+ +++ SED V+IW + Y Sbjct: 209 RLVKIWDY---QNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTY 261 >5NNZ-B nrPDB Length = 415 Score = 55.8 bits (133), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 62/234 (26%), Positives = 97/234 (41%), Gaps = 38/234 (16%) Query: 28 KIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWK 87 KI KT LW +E Y T +GH AE+ C+ F P S + + S D K+W Sbjct: 149 KIATGSFDKTCKLW-SVETGK--CYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLW- 204 Query: 88 FTDYSHLQCIQTIQHYSKTIVALSALPS--LISVGCADGTISIWRQNI-QNDEFGLAHEF 144 D + + + T++ +S I++LS S I G D T+ +W + + + H Sbjct: 205 --DIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCA 262 Query: 145 TIKKGFF---YPLCLSLSKVEEKKYLLAIGGTNVNV--------------FIASFILSDS 187 I F L L+ S + K A G V + I + S Sbjct: 263 EISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATAS 322 Query: 188 GIEKCRV--------VAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW 233 R+ +A+LEGHE + ++F Q G++LL +GS D+ R+W Sbjct: 323 ADGTARIFSAATRKCIAKLEGHEGEISKISFNPQ---GNHLL-TGSSDKTARIW 372 Score = 46.6 bits (109), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 24/80 (30%), Positives = 42/80 (52%), Gaps = 5/80 (6%) Query: 53 ATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTI--VAL 110 A L+GHE E++ + F P + +++ S D +IW D QC+Q ++ ++ I A Sbjct: 339 AKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW---DAQTGQCLQVLEGHTDEIFSCAF 395 Query: 111 SALPSLISVGCADGTISIWR 130 + +++ G D T IWR Sbjct: 396 NYKGNIVITGSKDNTCRIWR 415 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 39/135 (28%), Positives = 59/135 (43%), Gaps = 17/135 (12%) Query: 551 VEKLYGHGFEI--TCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLT 608 V L GH EI +C D + KLIA+A + RIFS I L H Sbjct: 296 VATLTGHDDEILDSCFDYTG--KLIATA-----SADGTARIFSAATRKCI-AKLEGHEGE 347 Query: 609 ITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGN 668 I+++ F+ G LL+ D+ +W+ L + HT I+ + GN Sbjct: 348 ISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVL-----EGHTDEIFSCAFNYK--GN 400 Query: 669 VFVTASRDKTVKVWR 683 + +T S+D T ++WR Sbjct: 401 IVITGSKDNTCRIWR 415 Score = 39.3 bits (90), Expect = 0.007, Method: Compositional matrix adjust. Identities = 43/184 (23%), Positives = 72/184 (39%), Gaps = 31/184 (16%) Query: 547 LWP-EVEKLY----GHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPA 601 LW E K Y GH EI CL +P L+A+ + +++ +N E+ Sbjct: 161 LWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATG-----SMDTTAKLWDIQNGEEVY-T 214 Query: 602 LPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADW 661 L HS I L F+ G +++ D +W+ + K + I A+ Sbjct: 215 LRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADT----------GRKVNILIGHCAEI 264 Query: 662 APLEFG---NVFVTASRDKTVKVWRHQKEPA-------DDYVLEASIKHTKAVTAISIHD 711 + F ++ +T S DKT K+W DD +L++ +T + A + D Sbjct: 265 SSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASAD 324 Query: 712 SMIR 715 R Sbjct: 325 GTAR 328 Score = 34.3 bits (77), Expect = 0.19, Method: Compositional matrix adjust. Identities = 75/362 (20%), Positives = 133/362 (36%), Gaps = 75/362 (20%) Query: 51 VYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVAL 110 ++ LK H +T V ++ S D K+W L ++ ++ I Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143 Query: 111 SALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAI 170 + I+ G D T +W E G + T + +CLS + + L+A Sbjct: 144 NPYGDKIATGSFDKTCKLWSV-----ETGKCYH-TFRGHTAEIVCLSFN---PQSTLVAT 194 Query: 171 GGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYI 230 G + + I+ V L GH + SL+F T GD ++ +GS D + Sbjct: 195 GSMDTTAKLWD-------IQNGEEVYTLRGHSAEIISLSFN---TSGDRII-TGSFDHTV 243 Query: 231 RLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWH 290 +W + +K+ +L +GH ISS ++ Sbjct: 244 VVW----------DADTGRKVNIL-----------------------IGHCAEISSASFN 270 Query: 291 ESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFW-SCLWFTH 349 +L + D + +W D T+G K +T TG SC +T Sbjct: 271 WDCSLILTGSMDKTCKLW--DATNG-------------KCVATLTGHDDEILDSCFDYTG 315 Query: 350 ERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTT 409 + T G+ R+++ C +L G +++ I+++P G +LL S D+T Sbjct: 316 K---LIATASADGTARIFSAATR-KCIAKL--EGHEGEISKISFNPQGNHLLTGSSDKTA 369 Query: 410 RL 411 R+ Sbjct: 370 RI 371 Score = 32.0 bits (71), Expect = 1.0, Method: Compositional matrix adjust. Identities = 23/83 (27%), Positives = 36/83 (43%), Gaps = 10/83 (12%) Query: 602 LPFHSLTITRLKFSKDGKFLLSVCRDRKWALWE--RNMEDNTFELRFKNEKPHTRIIWDA 659 L H L +T + +K G ++ DR LW+ E NT E H +++ Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLE-------GHRNVVYAI 140 Query: 660 DWAPLEFGNVFVTASRDKTVKVW 682 + +G+ T S DKT K+W Sbjct: 141 AFNN-PYGDKIATGSFDKTCKLW 162 >5Z56-q nrPDB Length = 504 Score = 54.7 bits (130), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 29/84 (34%), Positives = 47/84 (55%), Gaps = 6/84 (7%) Query: 28 KIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWK 87 KI+ GA K + ++D +++ + ATLKGH +VT V F P D + SAS D ++IW Sbjct: 236 KILTGGADKNVVVFDK---SSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 292 Query: 88 FTDYSHLQCIQTIQHYSKTIVALS 111 + S C+Q ++ + + LS Sbjct: 293 VPNAS---CVQVVRAHESAVTGLS 313 Score = 38.5 bits (88), Expect = 0.010, Method: Compositional matrix adjust. Identities = 34/129 (26%), Positives = 57/129 (44%), Gaps = 11/129 (8%) Query: 554 LYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLK 613 L GH ++T + P Q L+ SA +A IRI+S N ++ + H +T L Sbjct: 260 LKGHTKKVTSVVFHPSQDLVFSAS-----PDATIRIWSVPNASCVQ-VVRAHESAVTGLS 313 Query: 614 FSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTA 673 G +LLS D+ WA +++ + +E + A + P G +F T Sbjct: 314 LHATGDYLLSSSDDQYWAF--SDIQTGRVLTKVTDETSGCSLTC-AQFHP--DGLIFGTG 368 Query: 674 SRDKTVKVW 682 + D +K+W Sbjct: 369 TMDSQIKIW 377 Score = 38.1 bits (87), Expect = 0.013, Method: Compositional matrix adjust. Identities = 24/103 (23%), Positives = 45/103 (43%), Gaps = 6/103 (5%) Query: 32 FGAG---KTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 FG G I +WD E N A GH +T + F + ++ +A++D VK+W Sbjct: 365 FGTGTMDSQIKIWDLKERTN---VANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDL 421 Query: 89 TDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQ 131 + + +Q ++ + + +++G D I I +Q Sbjct: 422 RKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQ 464 Score = 35.8 bits (81), Expect = 0.070, Method: Compositional matrix adjust. Identities = 57/259 (22%), Positives = 91/259 (35%), Gaps = 66/259 (25%) Query: 154 LCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQ 213 L L L + K L NV VF D E+ ++A L+GH V S+ F Sbjct: 225 LALDLCPSDTNKILTGGADKNVVVF-------DKSSEQ--ILATLKGHTKKVTSVVFH-- 273 Query: 214 ETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINF 273 P L+ S S D IR+W + + Sbjct: 274 --PSQDLVFSASPDATIRIWSVPNASCVQ------------------------------- 300 Query: 274 EALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCS-LRLGEMSSKGAS 332 ++ H+ ++ L H + LL+++ D W S ++ G + +K Sbjct: 301 --VVRAHESAVTGLSLHATGDYLLSSSDDQ------------YWAFSDIQTGRVLTKVTD 346 Query: 333 TATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIA 392 +G S +C F H F T ++W K+ G SG +T IA Sbjct: 347 ETSGCS---LTCAQF-HPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGP---ITSIA 399 Query: 393 WSPSGEYLLATSLDQTTRL 411 +S +G YL + D + +L Sbjct: 400 FSENGYYLATAADDSSVKL 418 Score = 35.8 bits (81), Expect = 0.083, Method: Compositional matrix adjust. Identities = 27/114 (23%), Positives = 45/114 (39%), Gaps = 6/114 (5%) Query: 558 GFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKD 617 G +TC PD + + ++ I+I+ + + P HS IT + FS++ Sbjct: 350 GCSLTCAQFHPDGLIFGTG-----TMDSQIKIWDLKERTNVA-NFPGHSGPITSIAFSEN 403 Query: 618 GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFV 671 G +L + D LW+ N L+ N +I+D L G V Sbjct: 404 GYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDV 457 Score = 34.7 bits (78), Expect = 0.14, Method: Compositional matrix adjust. Identities = 34/178 (19%), Positives = 68/178 (38%), Gaps = 30/178 (16%) Query: 62 VTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTI--VALSALPSLISV 119 +TC +F PD + + D +KIW + ++ + +S I +A S ++ Sbjct: 353 LTCAQFHPDGLIFGTGTMDSQIKIWDLKERTN---VANFPGHSGPITSIAFSENGYYLAT 409 Query: 120 GCADGTISIW--RQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNV 177 D ++ +W R+ L + F +K F ++ LA+GGT+V + Sbjct: 410 AADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIF----------DQSGTYLALGGTDVQI 459 Query: 178 FIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI 235 +I ++ + H +AF H + S DR ++ + + Sbjct: 460 YIC---------KQWTEILHFTEHSGLTTGVAFGHHAK----FIASTGMDRSLKFYSL 504 Score = 29.6 bits (65), Expect = 5.7, Method: Compositional matrix adjust. Identities = 34/137 (24%), Positives = 54/137 (39%), Gaps = 17/137 (12%) Query: 9 AIFIGANKQTQVSDIHKVKKIVAFGAGK--TIALWDPIEPNNKGVYATLKGHEAEVTCVR 66 A G K+ H + +V F A TI +W PN V ++ HE+ VT + Sbjct: 258 ATLKGHTKKVTSVVFHPSQDLV-FSASPDATIRIWS--VPNASCVQV-VRAHESAVTGLS 313 Query: 67 FVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTI----QHYSKTIVALSALPSLISVGCA 122 D+++S+S+D + W F+D + + + S T + G Sbjct: 314 LHATGDYLLSSSDDQY---WAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTM 370 Query: 123 DGTISIW----RQNIQN 135 D I IW R N+ N Sbjct: 371 DSQIKIWDLKERTNVAN 387 >6Q8F-A nrPDB Length = 514 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 45/192 (23%), Positives = 79/192 (41%), Gaps = 30/192 (15%) Query: 57 GHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYS-----HLQCIQTIQHYSKTIVAL- 110 G ++ V C RF PD ++V+ S D +++W FT Q ++ + Sbjct: 213 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMC 272 Query: 111 -SALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLA 169 S +++ G DG I +W+ IQ+ + E KG CLS SK Sbjct: 273 FSRDTEMLATGAQDGKIKVWK--IQSGQCLRRFERAHSKGV---TCLSFSK--------- 318 Query: 170 IGGTNVNVFIASF--ILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQD 227 + + ASF + G++ + + E GH +V F G Y++ S S D Sbjct: 319 ---DSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQD---GHYII-SASSD 371 Query: 228 RYIRLWRIRIND 239 +++W ++ + Sbjct: 372 GTVKIWNMKTTE 383 Score = 35.4 bits (80), Expect = 0.095, Method: Compositional matrix adjust. Identities = 29/122 (23%), Positives = 56/122 (45%), Gaps = 12/122 (9%) Query: 561 ITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKF 620 + C+ S D +++A+ Q+ I+++ ++ ++ HS +T L FSKD Sbjct: 268 VLCMCFSRDTEMLATG-----AQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQ 322 Query: 621 LLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVK 680 +LS D+ + E R H+ + +A + + G+ ++AS D TVK Sbjct: 323 ILSASFDQTIRIHGLKSGKTLKEFR-----GHSSFVNEATFT--QDGHYIISASSDGTVK 375 Query: 681 VW 682 +W Sbjct: 376 IW 377 Score = 31.2 bits (69), Expect = 2.0, Method: Compositional matrix adjust. Identities = 46/224 (20%), Positives = 92/224 (41%), Gaps = 29/224 (12%) Query: 220 LLCSGSQDRYIRLWRIRINDLIDDSEE-DSKKLTLLSNKQYKFQI-----DDELRV-GIN 272 +L +G+QD I++W+I+ + E SK +T LS + QI D +R+ G+ Sbjct: 279 MLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLK 338 Query: 273 FEALI---MGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSK 329 + GH +++ + + +++A++D ++ +W T CS + S Sbjct: 339 SGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTE----CSNTFKSLGST 394 Query: 330 GASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATK--D 387 + T +S + + + F+ ++ + + + I+ R SG + D Sbjct: 395 AGTDITVNS------VILLPKNPEHFVVCNRSNTVVIMNMQGQIV---RSFSSGKREGGD 445 Query: 388 VTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHE 431 A SP GE++ D F+ +G+ T HE Sbjct: 446 FVCCALSPRGEWIYCVGEDFVLYCFST----VTGKLERTLTVHE 485 Score = 30.8 bits (68), Expect = 2.2, Method: Compositional matrix adjust. Identities = 29/132 (21%), Positives = 50/132 (37%), Gaps = 6/132 (4%) Query: 556 GHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFS 615 H +TCL S D I SA + IRI ++ +K HS + F+ Sbjct: 306 AHSKGVTCLSFSKDSSQILSASF-----DQTIRIHGLKSGKTLK-EFRGHSSFVNEATFT 359 Query: 616 KDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASR 675 +DG +++S D +W + + + T I ++ + FV +R Sbjct: 360 QDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNR 419 Query: 676 DKTVKVWRHQKE 687 TV + Q + Sbjct: 420 SNTVVIMNMQGQ 431 Score = 30.4 bits (67), Expect = 2.8, Method: Compositional matrix adjust. Identities = 13/34 (38%), Positives = 18/34 (52%) Query: 55 LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 +GH + V F D +++SAS D VKIW Sbjct: 346 FRGHSSFVNEATFTQDGHYIISASSDGTVKIWNM 379 Score = 29.3 bits (64), Expect = 6.5, Method: Compositional matrix adjust. Identities = 20/74 (27%), Positives = 32/74 (43%), Gaps = 1/74 (1%) Query: 56 KGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS 115 + H VTC+ F DS ++SAS D ++I L+ + + Sbjct: 305 RAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHY 364 Query: 116 LISVGCADGTISIW 129 +IS +DGT+ IW Sbjct: 365 IISAS-SDGTVKIW 377 >4LG8-A nrPDB Length = 354 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 29/84 (34%), Positives = 47/84 (55%), Gaps = 6/84 (7%) Query: 28 KIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWK 87 KI+ GA K + ++D +++ + ATLKGH +VT V F P D + SAS D ++IW Sbjct: 86 KILTGGADKNVVVFDK---SSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 142 Query: 88 FTDYSHLQCIQTIQHYSKTIVALS 111 + S C+Q ++ + + LS Sbjct: 143 VPNAS---CVQVVRAHESAVTGLS 163 Score = 39.7 bits (91), Expect = 0.005, Method: Compositional matrix adjust. Identities = 24/103 (23%), Positives = 45/103 (43%), Gaps = 6/103 (5%) Query: 32 FGAG---KTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 FG G I +WD E N A GH +T + F + ++ +A++D VK+W Sbjct: 215 FGTGTMDSQIKIWDLKERTN---VANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDL 271 Query: 89 TDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQ 131 + + +Q ++ + + +++G D I I +Q Sbjct: 272 RKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQ 314 Score = 38.9 bits (89), Expect = 0.009, Method: Compositional matrix adjust. Identities = 34/129 (26%), Positives = 57/129 (44%), Gaps = 11/129 (8%) Query: 554 LYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLK 613 L GH ++T + P Q L+ SA +A IRI+S N ++ + H +T L Sbjct: 110 LKGHTKKVTSVVFHPSQDLVFSAS-----PDATIRIWSVPNASCVQ-VVRAHESAVTGLS 163 Query: 614 FSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTA 673 G +LLS D+ WA +++ + +E + A + P G +F T Sbjct: 164 LHATGDYLLSSSDDQYWAF--SDIQTGRVLTKVTDETSGCSLTC-AQFHP--DGLIFGTG 218 Query: 674 SRDKTVKVW 682 + D +K+W Sbjct: 219 TMDSQIKIW 227 Score = 36.6 bits (83), Expect = 0.041, Method: Compositional matrix adjust. Identities = 27/114 (23%), Positives = 45/114 (39%), Gaps = 6/114 (5%) Query: 558 GFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKD 617 G +TC PD + + ++ I+I+ + + P HS IT + FS++ Sbjct: 200 GCSLTCAQFHPDGLIFGTG-----TMDSQIKIWDLKERTNV-ANFPGHSGPITSIAFSEN 253 Query: 618 GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFV 671 G +L + D LW+ N L+ N +I+D L G V Sbjct: 254 GYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDV 307 Score = 35.4 bits (80), Expect = 0.091, Method: Compositional matrix adjust. Identities = 34/178 (19%), Positives = 68/178 (38%), Gaps = 30/178 (16%) Query: 62 VTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTI--VALSALPSLISV 119 +TC +F PD + + D +KIW + ++ + +S I +A S ++ Sbjct: 203 LTCAQFHPDGLIFGTGTMDSQIKIWDLKERTN---VANFPGHSGPITSIAFSENGYYLAT 259 Query: 120 GCADGTISIW--RQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNV 177 D ++ +W R+ L + F +K F ++ LA+GGT+V + Sbjct: 260 AADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIF----------DQSGTYLALGGTDVQI 309 Query: 178 FIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI 235 +I ++ + H +AF H + S DR ++ + + Sbjct: 310 YIC---------KQWTEILHFTEHSGLTTGVAFGHHAK----FIASTGMDRSLKFYSL 354 Score = 34.3 bits (77), Expect = 0.20, Method: Compositional matrix adjust. Identities = 57/259 (22%), Positives = 91/259 (35%), Gaps = 66/259 (25%) Query: 154 LCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQ 213 L L L + K L NV VF D E +++A L+GH V S+ F Sbjct: 75 LALDLCPSDTNKILTGGADKNVVVF-------DKSSE--QILATLKGHTKKVTSVVFH-- 123 Query: 214 ETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINF 273 P L+ S S D IR+W + + Sbjct: 124 --PSQDLVFSASPDATIRIWSVPNASCVQ------------------------------- 150 Query: 274 EALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCS-LRLGEMSSKGAS 332 ++ H+ ++ L H + LL+++ D W S ++ G + +K Sbjct: 151 --VVRAHESAVTGLSLHATGDYLLSSSDDQ------------YWAFSDIQTGRVLTKVTD 196 Query: 333 TATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIA 392 +G S +C F H F T ++W K+ G SG +T IA Sbjct: 197 ETSGCS---LTCAQF-HPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGP---ITSIA 249 Query: 393 WSPSGEYLLATSLDQTTRL 411 +S +G YL + D + +L Sbjct: 250 FSENGYYLATAADDSSVKL 268 Score = 30.4 bits (67), Expect = 3.1, Method: Compositional matrix adjust. Identities = 27/107 (25%), Positives = 44/107 (41%), Gaps = 14/107 (13%) Query: 37 TIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQC 96 TI +W PN V ++ HE+ VT + D+++S+S+D + W F+D + Sbjct: 137 TIRIWSV--PNASCV-QVVRAHESAVTGLSLHATGDYLLSSSDDQY---WAFSDIQTGRV 190 Query: 97 IQTI----QHYSKTIVALSALPSLISVGCADGTISIW----RQNIQN 135 + + S T + G D I IW R N+ N Sbjct: 191 LTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVAN 237 >1VYH-C nrPDB Length = 410 Score = 52.8 bits (125), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 67/305 (21%), Positives = 125/305 (40%), Gaps = 64/305 (20%) Query: 20 VSDI---HKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVS 76 V DI H K + + A TI LWD T+ GH+ V+ V +P+ D +VS Sbjct: 153 VQDISFDHSGKLLASCSADMTIKLWDF---QGFECIRTMHGHDHNVSSVSIMPNGDHIVS 209 Query: 77 ASEDHHVKIWKF-TDYSHLQCIQTIQHYSK--TIVALSALPSLISVGCADGTISIWRQNI 133 AS D +K+W+ T Y C++T + + +V + +LI+ D T+ +W Sbjct: 210 ASRDKTIKMWEVQTGY----CVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVAT 265 Query: 134 QNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGG-TNVNVFIASFILSDSGIEKC 192 + + L + + + S S + E A G T + F+LS S + Sbjct: 266 KECKAELREHRHVVECISWAPESSYSSISE-----ATGSETKKSGKPGPFLLSGSRDKTI 320 Query: 193 RV--------VAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDS 244 ++ + L GH++WV+ + F G + S + D+ +R+W + Sbjct: 321 KMWDVSTGMCLMTLVGHDNWVRGVLFH----SGGKFILSCADDKTLRVWDYK-------- 368 Query: 245 EEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTS 304 NK+ ++ H+ +++SL +H++ ++ + D + Sbjct: 369 -----------NKRCMKTLN--------------AHEHFVTSLDFHKTAPYVVTGSVDQT 403 Query: 305 LMVWE 309 + VWE Sbjct: 404 VKVWE 408 Score = 51.6 bits (122), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 61/300 (20%), Positives = 122/300 (40%), Gaps = 75/300 (25%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 +V+ TI +WD TLKGH V + F + S S D +K+W Sbjct: 123 MVSASEDATIKVWDY---ETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLW-- 177 Query: 89 TDYSHLQCIQTIQHYSKTIVALSALPS--LISVGCADGTISIWRQNIQNDEFGLAHEFTI 146 D+ +CI+T+ + + ++S +P+ I D TI +W +Q + + Sbjct: 178 -DFQGFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMW--EVQTG-------YCV 227 Query: 147 KKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVK 206 K + + + + + L+A + V + ++++ ++C+ AEL H V+ Sbjct: 228 KTFTGHREWVRMVRPNQDGTLIASCSNDQTVRV--WVVA---TKECK--AELREHRHVVE 280 Query: 207 SLAFRHQET-----------------PGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSK 249 +++ + + PG +LL SGS+D+ I++W + S Sbjct: 281 CISWAPESSYSSISEATGSETKKSGKPGPFLL-SGSRDKTIKMWDV------------ST 327 Query: 250 KLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWE 309 + L++ ++GHD+W+ + +H +L+ D +L VW+ Sbjct: 328 GMCLMT---------------------LVGHDNWVRGVLFHSGGKFILSCADDKTLRVWD 366 Score = 44.7 bits (104), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 36/138 (26%), Positives = 69/138 (50%), Gaps = 17/138 (12%) Query: 1 MVECIT--PEAIFIGANKQTQVSDIHKVKK----IVAFGAGKTIALWDPIEPNNKGVYAT 54 +VECI+ PE+ + ++ T S+ K K +++ KTI +WD + T Sbjct: 278 VVECISWAPESSYSSISEATG-SETKKSGKPGPFLLSGSRDKTIKMWDV---STGMCLMT 333 Query: 55 LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVAL---S 111 L GH+ V V F F++S ++D +++W DY + +C++T+ + + +L Sbjct: 334 LVGHDNWVRGVLFHSGGKFILSCADDKTLRVW---DYKNKRCMKTLNAHEHFVTSLDFHK 390 Query: 112 ALPSLISVGCADGTISIW 129 P +++ G D T+ +W Sbjct: 391 TAPYVVT-GSVDQTVKVW 407 Score = 38.5 bits (88), Expect = 0.011, Method: Compositional matrix adjust. Identities = 37/137 (27%), Positives = 59/137 (43%), Gaps = 13/137 (9%) Query: 549 PEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLT 608 PE L GH +T + P ++ SA ++A I+++ E + + L H+ + Sbjct: 99 PEKYALSGHRSPVTRVIFHPVFSVMVSAS-----EDATIKVWDYETG-DFERTLKGHTDS 152 Query: 609 ITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGN 668 + + F GK L S D LW+ FE + H + P G+ Sbjct: 153 VQDISFDHSGKLLASCSADMTIKLWDFQ----GFEC-IRTMHGHDHNVSSVSIMP--NGD 205 Query: 669 VFVTASRDKTVKVWRHQ 685 V+ASRDKT+K+W Q Sbjct: 206 HIVSASRDKTIKMWEVQ 222 Score = 37.0 bits (84), Expect = 0.037, Method: Compositional matrix adjust. Identities = 31/150 (20%), Positives = 61/150 (40%), Gaps = 29/150 (19%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 + ++GH ++ + I P+ I SA R + I+++ + +K H + Sbjct: 185 IRTMHGHDHNVSSVSIMPNGDHIVSASR-----DKTIKMWEVQTGYCVK-TFTGHREWVR 238 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPL------ 664 ++ ++DG + S D+ +W ++ ELR H ++ WAP Sbjct: 239 MVRPNQDGTLIASCSNDQTVRVWVVATKECKAELR-----EHRHVVECISWAPESSYSSI 293 Query: 665 ------------EFGNVFVTASRDKTVKVW 682 + G ++ SRDKT+K+W Sbjct: 294 SEATGSETKKSGKPGPFLLSGSRDKTIKMW 323 Score = 33.5 bits (75), Expect = 0.34, Method: Compositional matrix adjust. Identities = 46/234 (19%), Positives = 94/234 (40%), Gaps = 33/234 (14%) Query: 198 LEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLI---DDSEEDSKKLTLL 254 L+GH D V+ ++F H LL S S D I+LW + + I + + ++++ Sbjct: 146 LKGHTDSVQDISFDH----SGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIM 201 Query: 255 SNKQYKFQIDD-------ELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMV 307 N + E++ G + GH +W+ ++ ++ + + + D ++ V Sbjct: 202 PNGDHIVSASRDKTIKMWEVQTGYCVKTFT-GHREWVRMVRPNQDGTLIASCSNDQTVRV 260 Query: 308 W---------EPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTN 358 W E E + C E S S ATGS + + F L+ Sbjct: 261 WVVATKECKAELREHRHVVECISWAPESSYSSISEATGSETK------KSGKPGPFLLSG 314 Query: 359 GKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLF 412 + + +MW + + + G V + + G+++L+ + D+T R++ Sbjct: 315 SRDKTIKMWDVSTGMCL---MTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365 >2H9P-A nrPDB Length = 329 Score = 52.8 bits (125), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 57/217 (26%), Positives = 90/217 (41%), Gaps = 28/217 (12%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 +V+ KT+ +WD ++ TLKGH V C F P S+ +VS S D V+IW Sbjct: 97 LVSASDDKTLKIWDV---SSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW-- 151 Query: 89 TDYSHLQCIQTIQHYSKTIVAL--SALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTI 146 D +C++T+ +S + A+ + SLI DG IW L + Sbjct: 152 -DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 210 Query: 147 KKGF--FYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDW 204 F F P KY+LA N + L D KC + GH++ Sbjct: 211 PVSFVKFSP---------NGKYILAATLDN------TLKLWDYSKGKC--LKTYTGHKN- 252 Query: 205 VKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLI 241 K F + G + SGS+D + +W ++ +++ Sbjct: 253 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 289 Score = 47.0 bits (110), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 58/233 (24%), Positives = 94/233 (40%), Gaps = 28/233 (12%) Query: 43 PIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQH 102 P++PN + TL GH V+ V+F P+ +++ S+S D +KIW D + I Sbjct: 25 PVKPN-YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG-HK 82 Query: 103 YSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVE 162 + VA S+ +L+ D T+ IW D T+K Y C + + Sbjct: 83 LGISDVAWSSDSNLLVSASDDKTLKIW------DVSSGKCLKTLKGHSNYVFCCNFNPQS 136 Query: 163 EKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLC 222 L + G+ F S + D KC + L H D V ++ F + L+ Sbjct: 137 N----LIVSGS----FDESVRIWDVKTGKC--LKTLPAHSDPVSAVHFNRDGS----LIV 182 Query: 223 SGSQDRYIRLWRIR----INDLIDDSEEDSKKLTLLSNKQYKFQ--IDDELRV 269 S S D R+W + LIDD + N +Y +D+ L++ Sbjct: 183 SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 235 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 74/356 (20%), Positives = 143/356 (40%), Gaps = 77/356 (21%) Query: 378 RLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQI 437 + ++G TK V+ + +SP+GE+L ++S D+ +++ YD G+ + + H+ + Sbjct: 33 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA--YD--GKFEKTISGHKLGISDV 88 Query: 438 HGYDMICVETVTDTRFVSGGDEKILRSFDLPKG-----VAGMLQKFVGIQFEEKSEMPDS 492 + VS D+K L+ +D+ G + G F +S + S Sbjct: 89 -------AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 141 Query: 493 ATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVE 552 G E+ I D + +C ++ Sbjct: 142 -------------------------GSFDESVRIWD-VKTGKC---------------LK 160 Query: 553 KLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRL 612 L H ++ + + D LI S+ + + RI+ T + +K + + ++ + Sbjct: 161 TLPAHSDPVSAVHFNRDGSLIVSSSY-----DGLCRIWDTASGQCLKTLIDDDNPPVSFV 215 Query: 613 KFSKDGKFLLSVCRDRKWALWERNMED--NTFELRFKNEKPHTRIIWDADWAPLEFGNVF 670 KFS +GK++L+ D LW+ + T+ KNEK I+ A+++ + G Sbjct: 216 KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT-GHKNEK---YCIF-ANFS-VTGGKWI 269 Query: 671 VTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLEN 726 V+ S D V +W Q + +++ HT V + + H + E I+ S LEN Sbjct: 270 VSGSEDNLVYIWNLQTKE----IVQKLQGHTDVVISTACHPT---ENIIASAALEN 318 Score = 39.3 bits (90), Expect = 0.007, Method: Compositional matrix adjust. Identities = 28/85 (32%), Positives = 43/85 (50%), Gaps = 7/85 (8%) Query: 598 IKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIW 657 +K L H+ ++ +KFS +G++L S D+ +W D FE K H I Sbjct: 32 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW--GAYDGKFE---KTISGHKLGIS 86 Query: 658 DADWAPLEFGNVFVTASRDKTVKVW 682 D W+ N+ V+AS DKT+K+W Sbjct: 87 DVAWS--SDSNLLVSASDDKTLKIW 109 Score = 38.5 bits (88), Expect = 0.011, Method: Compositional matrix adjust. Identities = 50/211 (23%), Positives = 91/211 (43%), Gaps = 28/211 (13%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 IV+ +++ +WD TL H V+ V F D +VS+S D +IW Sbjct: 139 IVSGSFDESVRIWDV---KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW-- 193 Query: 89 TDYSHLQCIQTI---QHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFT 145 D + QC++T+ + + V S I D T+ +W + + +T Sbjct: 194 -DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS----KGKCLKTYT 248 Query: 146 IKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWV 205 K Y + + S V K++++ N+ V+I + ++ +V +L+GH D V Sbjct: 249 GHKNEKYCIFANFS-VTGGKWIVSGSEDNL-VYIWN-------LQTKEIVQKLQGHTDVV 299 Query: 206 KSLAFRHQETPGDYLLCSGS--QDRYIRLWR 234 S A P + ++ S + D+ I+LW+ Sbjct: 300 ISTACH----PTENIIASAALENDKTIKLWK 326 Score = 36.2 bits (82), Expect = 0.053, Method: Compositional matrix adjust. Identities = 68/292 (23%), Positives = 108/292 (36%), Gaps = 77/292 (26%) Query: 198 LEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNK 257 L GH V S+ F +P L S S D+ I++W D K Sbjct: 36 LAGHTKAVSSVKF----SPNGEWLASSSADKLIKIW----------GAYDGK-------- 73 Query: 258 QYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIW 317 FE I GH IS + W L++A+ D +L +W D +SG Sbjct: 74 ---------------FEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIW--DVSSGKC 116 Query: 318 VCSLR----------LGEMSSKGASTATGSSGGFW-----SCLWFTHERMD--------- 353 + +L+ S+ S + S W CL D Sbjct: 117 LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNR 176 Query: 354 ---FFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTR 410 +++ G R+W T C + L I V+ + +SP+G+Y+LA +LD T + Sbjct: 177 DGSLIVSSSYDGLCRIWDTASGQ-CLKTL-IDDDNPPVSFVKFSPNGKYILAATLDNTLK 234 Query: 411 LFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKIL 462 L W Y + G+ + T H+ + Y + +VT +++ G E L Sbjct: 235 L---WDY-SKGKCLKTYTGHKNEK-----YCIFANFSVTGGKWIVSGSEDNL 277 >5M25-A nrPDB Length = 434 Score = 52.4 bits (124), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 57/217 (26%), Positives = 90/217 (41%), Gaps = 28/217 (12%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 +V+ KT+ +WD ++ TLKGH V C F P S+ +VS S D V+IW Sbjct: 202 LVSASDDKTLKIWDV---SSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW-- 256 Query: 89 TDYSHLQCIQTIQHYSKTIVAL--SALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTI 146 D +C++T+ +S + A+ + SLI DG IW L + Sbjct: 257 -DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 315 Query: 147 KKGF--FYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDW 204 F F P KY+LA N + L D KC + GH++ Sbjct: 316 PVSFVKFSP---------NGKYILAATLDN------TLKLWDYSKGKC--LKTYTGHKN- 357 Query: 205 VKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLI 241 K F + G + SGS+D + +W ++ +++ Sbjct: 358 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 394 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 58/232 (25%), Positives = 91/232 (39%), Gaps = 26/232 (11%) Query: 32 FGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDY 91 G T + P++PN + TL GH V+ V+F P+ +++ S+S D +KIW D Sbjct: 119 IGGSATQSKPTPVKPN-YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG 177 Query: 92 SHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFF 151 + I + VA S+ +L+ D T+ IW D T+K Sbjct: 178 KFEKTISG-HKLGISDVAWSSDSNLLVSASDDKTLKIW------DVSSGKCLKTLKGHSN 230 Query: 152 YPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFR 211 Y C + + L + G+ F S + D KC + L H D V ++ F Sbjct: 231 YVFCCNFNPQSN----LIVSGS----FDESVRIWDVKTGKC--LKTLPAHSDPVSAVHFN 280 Query: 212 HQETPGDYLLCSGSQDRYIRLWRIR----INDLIDDSEEDSKKLTLLSNKQY 259 + L+ S S D R+W + LIDD + N +Y Sbjct: 281 RDGS----LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKY 328 Score = 39.3 bits (90), Expect = 0.006, Method: Compositional matrix adjust. Identities = 50/211 (23%), Positives = 91/211 (43%), Gaps = 28/211 (13%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 IV+ +++ +WD TL H V+ V F D +VS+S D +IW Sbjct: 244 IVSGSFDESVRIWDV---KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW-- 298 Query: 89 TDYSHLQCIQTI---QHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFT 145 D + QC++T+ + + V S I D T+ +W + + +T Sbjct: 299 -DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS----KGKCLKTYT 353 Query: 146 IKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWV 205 K Y + + S V K++++ N+ V+I + ++ +V +L+GH D V Sbjct: 354 GHKNEKYCIFANFS-VTGGKWIVSGSEDNL-VYIWN-------LQTKEIVQKLQGHTDVV 404 Query: 206 KSLAFRHQETPGDYLLCSGS--QDRYIRLWR 234 S A P + ++ S + D+ I+LW+ Sbjct: 405 ISTACH----PTENIIASAALENDKTIKLWK 431 Score = 39.3 bits (90), Expect = 0.006, Method: Compositional matrix adjust. Identities = 28/85 (32%), Positives = 43/85 (50%), Gaps = 7/85 (8%) Query: 598 IKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIW 657 +K L H+ ++ +KFS +G++L S D+ +W D FE K H I Sbjct: 137 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW--GAYDGKFE---KTISGHKLGIS 191 Query: 658 DADWAPLEFGNVFVTASRDKTVKVW 682 D W+ N+ V+AS DKT+K+W Sbjct: 192 DVAWS--SDSNLLVSASDDKTLKIW 214 Score = 38.1 bits (87), Expect = 0.015, Method: Compositional matrix adjust. Identities = 68/292 (23%), Positives = 108/292 (36%), Gaps = 77/292 (26%) Query: 198 LEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNK 257 L GH V S+ F +P L S S D+ I++W D K Sbjct: 141 LAGHTKAVSSVKF----SPNGEWLASSSADKLIKIW----------GAYDGK-------- 178 Query: 258 QYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIW 317 FE I GH IS + W L++A+ D +L +W D +SG Sbjct: 179 ---------------FEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIW--DVSSGKC 221 Query: 318 VCSLR----------LGEMSSKGASTATGSSGGFW-----SCLWFTHERMD--------- 353 + +L+ S+ S + S W CL D Sbjct: 222 LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNR 281 Query: 354 ---FFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTR 410 +++ G R+W T C + L I V+ + +SP+G+Y+LA +LD T + Sbjct: 282 DGSLIVSSSYDGLCRIWDTASGQ-CLKTL-IDDDNPPVSFVKFSPNGKYILAATLDNTLK 339 Query: 411 LFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKIL 462 L W Y + G+ + T H+ + Y + +VT +++ G E L Sbjct: 340 L---WDY-SKGKCLKTYTGHKNEK-----YCIFANFSVTGGKWIVSGSEDNL 382 Score = 37.4 bits (85), Expect = 0.023, Method: Compositional matrix adjust. Identities = 46/220 (20%), Positives = 95/220 (43%), Gaps = 28/220 (12%) Query: 554 LYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLK 613 L GH ++ + SP+ + +AS+ + +I+I+ + + + + H L I+ + Sbjct: 141 LAGHTKAVSSVKFSPNGEWLASSS-----ADKLIKIWGAYDG-KFEKTISGHKLGISDVA 194 Query: 614 FSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTA 673 +S D L+S D+ +W D + K K H+ ++ ++ P N+ V+ Sbjct: 195 WSSDSNLLVSASDDKTLKIW-----DVSSGKCLKTLKGHSNYVFCCNFNPQS--NLIVSG 247 Query: 674 SRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYS 733 S D++V++W + L+ H+ V+A+ + R+ LI +G ++ Sbjct: 248 SFDESVRIW----DVKTGKCLKTLPAHSDPVSAVHFN----RDGSLIVSSSYDGLCRIWD 299 Query: 734 YTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGV 773 G+ L T +++D P + + NGK L Sbjct: 300 TASGQC-LKTLIDDDNPP------VSFVKFSPNGKYILAA 332 Score = 36.2 bits (82), Expect = 0.050, Method: Compositional matrix adjust. Identities = 43/178 (24%), Positives = 82/178 (46%), Gaps = 20/178 (11%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 ++ L H ++ + + D LI S+ + + RI+ T + +K + + ++ Sbjct: 264 LKTLPAHSDPVSAVHFNRDGSLIVSSS-----YDGLCRIWDTASGQCLKTLIDDDNPPVS 318 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNMED--NTFELRFKNEKPHTRIIWDADWAPLEFGN 668 +KFS +GK++L+ D LW+ + T+ KNEK I+ A+++ + G Sbjct: 319 FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY-TGHKNEK---YCIF-ANFS-VTGGK 372 Query: 669 VFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLEN 726 V+ S D V +W Q + +++ HT V + + H + E I+ S LEN Sbjct: 373 WIVSGSEDNLVYIWNLQTKE----IVQKLQGHTDVVISTACHPT---ENIIASAALEN 423 >5XYI-g nrPDB Length = 335 Score = 52.4 bits (124), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 49/177 (27%), Positives = 79/177 (44%), Gaps = 14/177 (7%) Query: 6 TPEAIFIGANK-QTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTC 64 TP IG N + VS ++ T+ LWD K ++ GH+ +V Sbjct: 71 TPFTRLIGHNHFVSDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFL---GHKKDVLG 127 Query: 65 VRFVPDSDFMVSASEDHHVKIWKF--TDYSHLQCIQTIQHYSKTIVALSALPSLISVGCA 122 V F P + ++S D+ VKIW + + LQC + + +A P +I+VGC Sbjct: 128 VTFSPCNRRIISVGRDNQVKIWNILGENKAELQCSSWVTSVACAPMADETSPLVIAVGCW 187 Query: 123 DGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFI 179 DG + IW +I+ E L EF G C S+ + K+++ GG++ V + Sbjct: 188 DGKVYIW--SIEK-EAKLIKEFKAHDG----RCTSVDFTPDGKWVIT-GGSDRKVVM 236 Score = 33.1 bits (74), Expect = 0.45, Method: Compositional matrix adjust. Identities = 41/183 (22%), Positives = 79/183 (43%), Gaps = 19/183 (10%) Query: 554 LYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFST-ENWLEIKPALPFHSLTITRL 612 GH I ++I + + SA R + V ++ T E W L H+ ++ + Sbjct: 29 FVGHNAAIESIEIDNEHNYLVSASRDKSA--LVWKLNRTQEQWATPFTRLIGHNHFVSDV 86 Query: 613 KFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVT 672 S+D LL+ D LW+ + T + F H + + ++P ++ Sbjct: 87 SLSRDASHLLTSSWDSTLRLWD--LSTRTTKKLFLG---HKKDVLGVTFSPCN--RRIIS 139 Query: 673 ASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREK--ILISVGLENGEIY 730 RD VK+W E +A ++ + VT+++ M E ++I+VG +G++Y Sbjct: 140 VGRDNQVKIWNILGEN------KAELQCSSWVTSVACA-PMADETSPLVIAVGCWDGKVY 192 Query: 731 LYS 733 ++S Sbjct: 193 IWS 195 Score = 29.6 bits (65), Expect = 4.7, Method: Compositional matrix adjust. Identities = 45/220 (20%), Positives = 85/220 (38%), Gaps = 48/220 (21%) Query: 53 ATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF--------TDYSHLQCIQTIQH-Y 103 AT GH A + + + +++VSAS D +WK T ++ L I H + Sbjct: 27 ATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRL-----IGHNH 81 Query: 104 SKTIVALSALPSLISVGCADGTISIWRQNIQ-NDEFGLAHEFTIKKGFFYPL---CLSLS 159 + V+LS S + D T+ +W + + + L H+ + F P +S+ Sbjct: 82 FVSDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIISVG 141 Query: 160 KVEEKKYLLAIGGTNVNVFIASFILSDS-------------------------GIEK-CR 193 + + K +G + +S++ S + IEK + Sbjct: 142 RDNQVKIWNILGENKAELQCSSWVTSVACAPMADETSPLVIAVGCWDGKVYIWSIEKEAK 201 Query: 194 VVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW 233 ++ E + H+ S+ F TP + +G DR + +W Sbjct: 202 LIKEFKAHDGRCTSVDF----TPDGKWVITGGSDRKVVMW 237 >6QX9-5O nrPDB Length = 357 Score = 51.2 bits (121), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 50/199 (25%), Positives = 88/199 (44%), Gaps = 25/199 (12%) Query: 529 PLSLLEC-PPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVI 587 P +LL+ PP LQ ++ L GH E+ C P+ +ASA + +I Sbjct: 41 PGALLQAGPPRCSSLQAPIML-----LSGHEGEVYCCKFHPNGSTLASAGF-----DRLI 90 Query: 588 RIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFK 647 +++ + L HS + L ++ DG L S D+ A+W+ + R K Sbjct: 91 LLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGE-----RVK 145 Query: 648 NEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAI 707 K HT + ++ + + T S D TVK+W +K+ A + ++T V A+ Sbjct: 146 RLKGHTSFV-NSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQ-----TFQNTYQVLAV 199 Query: 708 SIHDSMIREKILISVGLEN 726 + +D+ +IS G++N Sbjct: 200 TFNDT---SDQIISGGIDN 215 Score = 50.4 bits (119), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 45/210 (21%), Positives = 87/210 (41%), Gaps = 27/210 (12%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 + + G + I LW+ + YATLKGH V + + D + SAS D V +W Sbjct: 81 LASAGFDRLILLWNVYGDCDN--YATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDS 138 Query: 89 TDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIW--RQNIQNDEFGLAHEFTI 146 ++ ++ + + P L+ G DGT+ +W R+ F Sbjct: 139 ETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTF-------- 190 Query: 147 KKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVK 206 + + L ++ + ++ + GG + ++ + + + ++ + GH D V Sbjct: 191 -QNTYQVLAVTFNDTSDQ---IISGGIDNDIKVWD-------LRQNKLTYTMRGHADSVT 239 Query: 207 SLAFRHQETPGDYLLCSGSQDRYIRLWRIR 236 L+ + G YLL S + D +R+W +R Sbjct: 240 GLSLSSE---GSYLL-SNAMDNTVRVWDVR 265 Score = 42.7 bits (99), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 33/134 (24%), Positives = 66/134 (49%), Gaps = 11/134 (8%) Query: 28 KIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWK 87 +I++ G I +WD + NK Y T++GH VT + + +++S + D+ V++W Sbjct: 207 QIISGGIDNDIKVWDLRQ--NKLTY-TMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWD 263 Query: 88 FTDYSHLQ-CIQTIQ----HYSKTIVALSALP--SLISVGCADGTISIWRQNIQNDEFGL 140 ++ + C++ Q ++ K ++ S P S I+ G AD + +W + + L Sbjct: 264 VRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKL 323 Query: 141 -AHEFTIKKGFFYP 153 H +I + F+P Sbjct: 324 PGHAGSINEVAFHP 337 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 31/123 (25%), Positives = 54/123 (43%), Gaps = 11/123 (8%) Query: 195 VAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTL- 253 V L+GH +V S + G L+C+GS D ++LW IR I + + L + Sbjct: 144 VKRLKGHTSFVNSC---YPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVT 200 Query: 254 ---LSNKQYKFQIDDELRV----GINFEALIMGHDDWISSLQWHESRLQLLAATADTSLM 306 S++ ID++++V + GH D ++ L LL+ D ++ Sbjct: 201 FNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVR 260 Query: 307 VWE 309 VW+ Sbjct: 261 VWD 263 Score = 38.5 bits (88), Expect = 0.011, Method: Compositional matrix adjust. Identities = 21/77 (27%), Positives = 37/77 (48%), Gaps = 4/77 (5%) Query: 55 LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVAL--SA 112 L GHE EV C +F P+ + SA D + +W Y T++ +S ++ L + Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNV--YGDCDNYATLKGHSGAVMELHYNT 119 Query: 113 LPSLISVGCADGTISIW 129 S++ D T+++W Sbjct: 120 DGSMLFSASTDKTVAVW 136 Score = 31.6 bits (70), Expect = 1.4, Method: Compositional matrix adjust. Identities = 17/56 (30%), Positives = 27/56 (48%), Gaps = 3/56 (5%) Query: 28 KIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHV 83 KI A A + + +WD ++ + L GH + V F PD ++SAS D + Sbjct: 299 KIAAGSADRFVYVWDT---TSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351 Score = 29.6 bits (65), Expect = 5.9, Method: Compositional matrix adjust. Identities = 32/127 (25%), Positives = 50/127 (39%), Gaps = 24/127 (18%) Query: 605 HSLTITRLKFSKDGKFLLSVCRDRKWALW--------ERNMEDNTFELRFKN-EKPHTRI 655 H+ ++T L S +G +LLS D +W ER ++ F+ N EK R Sbjct: 234 HADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVK--IFQGNVHNFEKNLLRC 291 Query: 656 IWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIR 715 W D G+ S D+ V VW + +L H ++ ++ H Sbjct: 292 SWSPD------GSKIAAGSADRFVYVW----DTTSRRILYKLPGHAGSINEVAFHPD--- 338 Query: 716 EKILISV 722 E I+IS Sbjct: 339 EPIIISA 345 Score = 29.6 bits (65), Expect = 6.0, Method: Compositional matrix adjust. Identities = 35/173 (20%), Positives = 67/173 (38%), Gaps = 39/173 (22%) Query: 275 ALIMGHDDWISSLQWHESRLQLLAATADTSLMVWE---------------------PDET 313 A + GH + L ++ L +A+ D ++ VW+ P Sbjct: 103 ATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARR 162 Query: 314 SGIWVCS------LRLGEMSSKGASTATGSSGGFWSCLWFT-HERMDFFLTNGKTGSWRM 366 VC+ ++L ++ K A ++ + L T ++ D ++ G ++ Sbjct: 163 GPQLVCTGSDDGTVKLWDIRKKAAIQTFQNT---YQVLAVTFNDTSDQIISGGIDNDIKV 219 Query: 367 WATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRL-----FAP 414 W + N + + G VT ++ S G YLL+ ++D T R+ FAP Sbjct: 220 WDLRQNKLT---YTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAP 269 >5MZH-A nrPDB Length = 452 Score = 50.4 bits (119), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 77/350 (22%), Positives = 129/350 (36%), Gaps = 94/350 (26%) Query: 28 KIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWK 87 KIV KT LWD +Y TLKGH+ E+ C+ F P S + + S D+ K+W Sbjct: 151 KIVTGSFDKTCKLWDAYTGQ---LYYTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLW- 206 Query: 88 FTDYSHLQCIQTIQHYSKTIVAL--SALPSLISVGCADGTISIWRQNIQNDEFGLAHEFT 145 D Q T+ + IV+L + LI G D +W +++ + H + Sbjct: 207 --DVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLW--DVRTGQ--CVHVLS 260 Query: 146 IKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDS--------GIEKCRVVAE 197 +G + T N + + ++S S + R ++ Sbjct: 261 GHRG-------------------EVSSTQFN-YAGTLVVSGSIDCTSRLWDVRSGRCLSV 300 Query: 198 LEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNK 257 +GH D V +AF T + S S D RL+ TL Sbjct: 301 KQGHTDEVLDVAFDAAGTK----MVSASADGSARLYH-----------------TLTGVC 339 Query: 258 QYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIW 317 Q+ ++GH+ IS + ++ +L+ A++D + +W+ D + Sbjct: 340 QHT----------------LVGHEGEISKVAFNPQGTRLITASSDKTCRLWDCDTGECLQ 383 Query: 318 VCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMW 367 V G + +SC F +E DF +T K + R+W Sbjct: 384 VLE---------------GHTDEIFSCA-FNYEG-DFIITGSKDNTCRIW 416 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 48/183 (26%), Positives = 76/183 (41%), Gaps = 27/183 (14%) Query: 55 LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTI--VALSA 112 L GH EV+ +F +VS S D ++W D +C+ Q ++ + VA A Sbjct: 259 LSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLW---DVRSGRCLSVKQGHTDEVLDVAFDA 315 Query: 113 LPSLISVGCADGTISIWRQNIQNDEFGL-AHEFTIKKGFFYPLCLSLSKVEEKKYLLAIG 171 + + ADG+ ++ + L HE I K F P L K Sbjct: 316 AGTKMVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTRLITASSDK------ 369 Query: 172 GTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIR 231 + L D +C V LEGH D + S AF ++ GD+++ +GS+D R Sbjct: 370 ---------TCRLWDCDTGECLQV--LEGHTDEIFSCAFNYE---GDFII-TGSKDNTCR 414 Query: 232 LWR 234 +W+ Sbjct: 415 IWK 417 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 24/79 (30%), Positives = 39/79 (49%), Gaps = 5/79 (6%) Query: 54 TLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTI--VALS 111 TL GHE E++ V F P +++AS D ++W D +C+Q ++ ++ I A + Sbjct: 342 TLVGHEGEISKVAFNPQGTRLITASSDKTCRLW---DCDTGECLQVLEGHTDEIFSCAFN 398 Query: 112 ALPSLISVGCADGTISIWR 130 I G D T IW+ Sbjct: 399 YEGDFIITGSKDNTCRIWK 417 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 78/367 (21%), Positives = 139/367 (37%), Gaps = 85/367 (23%) Query: 51 VYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWK-FTDYSHLQCIQTIQHYSKTIVA 109 ++ L+ H +T F D ++ S D K+W FT + T++ + + A Sbjct: 86 LFKVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEE----VFTLEGHKNVVYA 141 Query: 110 LS---ALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKY 166 ++ I G D T +W D + +T+K +CLS + + Sbjct: 142 IAFNNPYGDKIVTGSFDKTCKLW------DAYTGQLYYTLKGHQTEIVCLSFNP---QST 192 Query: 167 LLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQ 226 ++A G + A ++G E+ A L GH + SL F T GD L+ +GS Sbjct: 193 IIATGSMDNT---AKLWDVETGQER----ATLAGHRAEIVSLGF---NTGGD-LIVTGSF 241 Query: 227 DRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISS 286 D RLW +R + ++ GH +SS Sbjct: 242 DHDSRLWDVRTGQCVH---------------------------------VLSGHRGEVSS 268 Query: 287 LQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSS--KGASTATGSSGGFWSC 344 Q++ + +++ + D + +W D SG + S++ G A A G+ Sbjct: 269 TQFNYAGTLVVSGSIDCTSRLW--DVRSGRCL-SVKQGHTDEVLDVAFDAAGTK------ 319 Query: 345 LWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATS 404 ++ GS R++ T + C L G +++ +A++P G L+ S Sbjct: 320 ----------MVSASADGSARLYHTLTGV-CQHTL--VGHEGEISKVAFNPQGTRLITAS 366 Query: 405 LDQTTRL 411 D+T RL Sbjct: 367 SDKTCRL 373 Score = 34.3 bits (77), Expect = 0.22, Method: Compositional matrix adjust. Identities = 22/81 (27%), Positives = 36/81 (44%), Gaps = 6/81 (7%) Query: 602 LPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADW 661 L H L +T F+K G ++ DR +W + F L + H +++ + Sbjct: 90 LRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTL-----EGHKNVVYAIAF 144 Query: 662 APLEFGNVFVTASRDKTVKVW 682 +G+ VT S DKT K+W Sbjct: 145 NN-PYGDKIVTGSFDKTCKLW 164 Score = 33.5 bits (75), Expect = 0.34, Method: Compositional matrix adjust. Identities = 22/81 (27%), Positives = 34/81 (41%), Gaps = 6/81 (7%) Query: 554 LYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLK 613 L GH EI CL +P +IA+ N +++ E E + L H I L Sbjct: 175 LKGHQTEIVCLSFNPQSTIIATGSMDNTA-----KLWDVETGQE-RATLAGHRAEIVSLG 228 Query: 614 FSKDGKFLLSVCRDRKWALWE 634 F+ G +++ D LW+ Sbjct: 229 FNTGGDLIVTGSFDHDSRLWD 249 >2YNP-A nrPDB Length = 604 Score = 50.1 bits (118), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 43/183 (23%), Positives = 77/183 (42%), Gaps = 22/183 (12%) Query: 55 LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF-TDYSHLQCIQTIQHYSKTIVALSAL 113 + H + + P +++S S+D VK+W + +++ Q + +H+ + Sbjct: 93 FEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKD 152 Query: 114 PSLISVGCADGTISIWR--QNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIG 171 PS + GC D T+ +W Q+ N E + +YPL +K Y++ Sbjct: 153 PSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPL-------PDKPYMITAS 205 Query: 172 GTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIR 231 + + D + C VA LEGH V S A H P ++ SGS+D ++ Sbjct: 206 DD------LTIKIWDYQTKSC--VATLEGHMSNV-SFAVFHPTLP---IIISGSEDGTLK 253 Query: 232 LWR 234 +W Sbjct: 254 IWN 256 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 40/139 (28%), Positives = 63/139 (45%), Gaps = 21/139 (15%) Query: 36 KTIALWDPIE--PNNKGVYATLKGHEAEVTCVRF--VPDSDFMVSASEDHHVKIWKFTDY 91 +T+ +W + PN + G E V V + +PD +M++AS+D +KIW DY Sbjct: 163 RTVKVWSLGQSTPN----FTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIW---DY 215 Query: 92 SHLQCIQTIQ-HYSKTIVAL--SALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKK 148 C+ T++ H S A+ LP +IS G DGT+ IW + E T+ Sbjct: 216 QTKSCVATLEGHMSNVSFAVFHPTLPIIIS-GSEDGTLKIWNSST------YKVEKTLNV 268 Query: 149 GFFYPLCLSLSKVEEKKYL 167 G C++ K Y+ Sbjct: 269 GLERSWCIATHPTGRKNYI 287 Score = 36.2 bits (82), Expect = 0.055, Method: Compositional matrix adjust. Identities = 42/186 (22%), Positives = 76/186 (40%), Gaps = 18/186 (9%) Query: 556 GHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFS 615 H I + + P + + S + +++++ EN ++ H + + F+ Sbjct: 95 AHPDYIRSIAVHPTKPYVLSGS-----DDLTVKLWNWENNWALEQTFEGHEHFVMCVAFN 149 Query: 616 -KDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTAS 674 KD S C DR +W F L E+ + D+ PL +TAS Sbjct: 150 PKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYV----DYYPLPDKPYMITAS 205 Query: 675 RDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSY 734 D T+K+W +Q + LE H V+ H ++ I+IS G E+G + +++ Sbjct: 206 DDLTIKIWDYQTKSCVA-TLEG---HMSNVSFAVFHPTL---PIIIS-GSEDGTLKIWNS 257 Query: 735 TLGKFE 740 + K E Sbjct: 258 STYKVE 263 Score = 28.9 bits (63), Expect = 7.9, Method: Compositional matrix adjust. Identities = 16/40 (40%), Positives = 24/40 (60%), Gaps = 4/40 (10%) Query: 195 VAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWR 234 V + E H D+++S+A H P Y+L SGS D ++LW Sbjct: 90 VVDFEAHPDYIRSIAV-HPTKP--YVL-SGSDDLTVKLWN 125 >3FM0-A nrPDB Length = 345 Score = 50.1 bits (118), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 49/186 (26%), Positives = 82/186 (44%), Gaps = 28/186 (15%) Query: 56 KGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS 115 +GH+ V V + P +++ SAS D IWK + +C+ T++ + + +++ PS Sbjct: 58 EGHQRTVRKVAWSPCGNYLASASFDATTCIWK-KNQDDFECVTTLEGHENEVKSVAWAPS 116 Query: 116 --LISVGCADGTISIWRQNIQNDEFGL-----AHEFTIKKGFFYPLCLSLSKVEEKKYLL 168 L++ D ++ +W + + DE+ +H +K ++P + LL Sbjct: 117 GNLLATCSRDKSVWVWEVD-EEDEYECVSVLNSHTQDVKHVVWHP----------SQELL 165 Query: 169 AIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDR 228 A + V + D A LEGHE V SLAF P L S S DR Sbjct: 166 ASASYDDTVKLYREEEDDW-----VCCATLEGHESTVWSLAF----DPSGQRLASCSDDR 216 Query: 229 YIRLWR 234 +R+WR Sbjct: 217 TVRIWR 222 Score = 48.9 bits (115), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 45/149 (30%), Positives = 72/149 (48%), Gaps = 14/149 (9%) Query: 587 IRIFSTE--NWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFEL 644 IRI+ TE +W+ H T+ ++ +S G +L S D +W++N +D FE Sbjct: 40 IRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDD--FEC 97 Query: 645 RFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIK-HTKA 703 E H + WAP GN+ T SRDK+V VW +E D+Y + + HT+ Sbjct: 98 VTTLEG-HENEVKSVAWAP--SGNLLATCSRDKSVWVWEVDEE--DEYECVSVLNSHTQD 152 Query: 704 VTAISIHDSMIREKILISVGLENGEIYLY 732 V + H S +++L S ++ + LY Sbjct: 153 VKHVVWHPS---QELLASASYDD-TVKLY 177 Score = 43.9 bits (102), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 30/108 (27%), Positives = 57/108 (52%), Gaps = 3/108 (2%) Query: 36 KTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQ 95 K++ +W+ E + + L H +V V + P + + SAS D VK+++ + + Sbjct: 127 KSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWV- 185 Query: 96 CIQTIQHYSKTIVALSALPSLISVG-CADG-TISIWRQNIQNDEFGLA 141 C T++ + T+ +L+ PS + C+D T+ IWRQ + +E G+A Sbjct: 186 CCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVA 233 Score = 43.9 bits (102), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 27/106 (25%), Positives = 52/106 (49%), Gaps = 7/106 (6%) Query: 54 TLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSAL 113 TL+GHE EV V + P + + + S D V +W+ + +C+ + +++ + + Sbjct: 100 TLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWH 159 Query: 114 PS--LISVGCADGTISIWRQNIQNDEFGLA----HEFTIKKGFFYP 153 PS L++ D T+ ++R+ ++D A HE T+ F P Sbjct: 160 PSQELLASASYDDTVKLYREE-EDDWVCCATLEGHESTVWSLAFDP 204 Score = 39.7 bits (91), Expect = 0.005, Method: Compositional matrix adjust. Identities = 29/100 (29%), Positives = 50/100 (50%), Gaps = 17/100 (17%) Query: 53 ATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWK-------------FTDYSHLQCIQT 99 ATL+GHE+ V + F P + S S+D V+IW+ +D S +CI T Sbjct: 188 ATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPS-WKCICT 246 Query: 100 IQHY-SKTI--VALSALPSLISVGCADGTISIWRQNIQND 136 + + S+TI +A L ++ C D I +++++ +D Sbjct: 247 LSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSD 286 Score = 37.4 bits (85), Expect = 0.028, Method: Compositional matrix adjust. Identities = 20/49 (40%), Positives = 28/49 (57%), Gaps = 2/49 (4%) Query: 365 RMWATK-DNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLF 412 R+W T+ D+ IC L G + V +AWSP G YL + S D TT ++ Sbjct: 41 RIWGTEGDSWICKSVLS-EGHQRTVRKVAWSPCGNYLASASFDATTCIW 88 Score = 35.8 bits (81), Expect = 0.076, Method: Compositional matrix adjust. Identities = 31/116 (26%), Positives = 59/116 (50%), Gaps = 22/116 (18%) Query: 194 VVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTL 253 V LEGHE+ VKS+A+ P LL + S+D+ + +W + D E++ + +++ Sbjct: 97 CVTTLEGHENEVKSVAW----APSGNLLATCSRDKSVWVWEV-------DEEDEYECVSV 145 Query: 254 LSN-----KQYKFQIDDELRVGINFEALIMGH----DDWI--SSLQWHESRLQLLA 298 L++ K + EL +++ + + DDW+ ++L+ HES + LA Sbjct: 146 LNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLA 201 Score = 30.0 bits (66), Expect = 3.7, Method: Compositional matrix adjust. Identities = 29/134 (21%), Positives = 51/134 (38%), Gaps = 8/134 (5%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 V L GH E+ + +P L+A+ R +V + E+ E L H+ + Sbjct: 98 VTTLEGHENEVKSVAWAPSGNLLATCSRDKSVW---VWEVDEEDEYECVSVLNSHTQDVK 154 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVF 670 + + + L S D L+ +D + H +W + P G Sbjct: 155 HVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEG---HESTVWSLAFDP--SGQRL 209 Query: 671 VTASRDKTVKVWRH 684 + S D+TV++WR Sbjct: 210 ASCSDDRTVRIWRQ 223 Score = 30.0 bits (66), Expect = 4.5, Method: Compositional matrix adjust. Identities = 16/53 (30%), Positives = 25/53 (47%), Gaps = 4/53 (7%) Query: 381 ISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAP----WIYDASGRKREIATW 429 ++ T+DV + W PS E L + S D T +L+ W+ A+ E W Sbjct: 146 LNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVW 198 >3DM0-A nrPDB Length = 694 Score = 49.7 bits (117), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 33/105 (31%), Positives = 53/105 (50%), Gaps = 3/105 (2%) Query: 27 KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDS--DFMVSASEDHHVK 84 ++IV+ +TI LW+ + + +GH V+CVRF P++ +VSAS D VK Sbjct: 485 RQIVSASRDRTIKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVK 544 Query: 85 IWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIW 129 +W ++ + Y T VA+S SL + G DG + +W Sbjct: 545 VWNLSNCKLRSTLAGHTGYVST-VAVSPDGSLCASGGKDGVVLLW 588 Score = 35.0 bits (79), Expect = 0.11, Method: Compositional matrix adjust. Identities = 44/219 (20%), Positives = 89/219 (40%), Gaps = 40/219 (18%) Query: 53 ATLKGHEAEVTCVRF-VPDSDFMVSASEDHHVKIWKFT--DYSHLQCIQTIQHYSKTI-- 107 T++ H VT + + ++D +VSAS D + +WK T D ++ + + +S + Sbjct: 376 GTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVED 435 Query: 108 VALSALPSLISVGCADGTISIW--------RQNIQNDEFGLAHEFTIKKGFFYPLCLSLS 159 V LS+ G DG + +W R+ + + + L+ F++ + Sbjct: 436 VVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSASRDRT 495 Query: 160 -----KVEEKKYLLAIGGTNVNVFIASFILSDSGIE------------------KCRVVA 196 + E KY ++ GG +++ S + ++ C++ + Sbjct: 496 IKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCKLRS 555 Query: 197 ELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI 235 L GH +V ++A +P L SG +D + LW + Sbjct: 556 TLAGHTGYVSTVAV----SPDGSLCASGGKDGVVLLWDL 590 Score = 33.1 bits (74), Expect = 0.43, Method: Compositional matrix adjust. Identities = 33/135 (24%), Positives = 61/135 (45%), Gaps = 12/135 (8%) Query: 605 HSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPL 664 H+ + + FS D + ++S RDR LW + + + + E H + ++P Sbjct: 471 HTKDVLSVAFSLDNRQIVSASRDRTIKLW-NTLGECKYTISEGGEG-HRDWVSCVRFSPN 528 Query: 665 EFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIK-HTKAVTAISIHDSMIREKILISVG 723 V+AS DKTVKVW + L +++ HT V+ +++ + L + G Sbjct: 529 TLQPTIVSASWDKTVKVWNLS-----NCKLRSTLAGHTGYVSTVAVSP----DGSLCASG 579 Query: 724 LENGEIYLYSYTLGK 738 ++G + L+ GK Sbjct: 580 GKDGVVLLWDLAEGK 594 Score = 32.0 bits (71), Expect = 1.0, Method: Compositional matrix adjust. Identities = 19/71 (26%), Positives = 32/71 (45%), Gaps = 3/71 (4%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 IV+ KT+ +W+ +N + +TL GH V+ V PD S +D V +W Sbjct: 534 IVSASWDKTVKVWNL---SNCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDL 590 Query: 89 TDYSHLQCIQT 99 + L ++ Sbjct: 591 AEGKKLYSLEA 601 Score = 29.3 bits (64), Expect = 6.1, Method: Compositional matrix adjust. Identities = 26/86 (30%), Positives = 42/86 (48%), Gaps = 7/86 (8%) Query: 602 LPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADW 661 L HS + + S DG+F LS D + LW+ + RF HT+ + + Sbjct: 426 LTGHSHFVEDVVLSSDGQFALSGSWDGELRLWD--LAAGVSTRRFVG---HTKDVLSVAF 480 Query: 662 APLEFGNVFVTASRDKTVKVWRHQKE 687 + L+ + V+ASRD+T+K+W E Sbjct: 481 S-LDNRQI-VSASRDRTIKLWNTLGE 504 >3MKQ-A nrPDB Length = 814 Score = 49.7 bits (117), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 43/183 (23%), Positives = 77/183 (42%), Gaps = 22/183 (12%) Query: 55 LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF-TDYSHLQCIQTIQHYSKTIVALSAL 113 + H + + P +++S S+D VK+W + +++ Q + +H+ + Sbjct: 93 FEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKD 152 Query: 114 PSLISVGCADGTISIWR--QNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIG 171 PS + GC D T+ +W Q+ N E + +YPL +K Y++ Sbjct: 153 PSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPL-------PDKPYMITAS 205 Query: 172 GTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIR 231 + + D + C VA LEGH V S A H P ++ SGS+D ++ Sbjct: 206 DD------LTIKIWDYQTKSC--VATLEGHMSNV-SFAVFHPTLP---IIISGSEDGTLK 253 Query: 232 LWR 234 +W Sbjct: 254 IWN 256 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 40/139 (28%), Positives = 63/139 (45%), Gaps = 21/139 (15%) Query: 36 KTIALWDPIE--PNNKGVYATLKGHEAEVTCVRF--VPDSDFMVSASEDHHVKIWKFTDY 91 +T+ +W + PN + G E V V + +PD +M++AS+D +KIW DY Sbjct: 163 RTVKVWSLGQSTPN----FTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIW---DY 215 Query: 92 SHLQCIQTIQ-HYSKTIVAL--SALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKK 148 C+ T++ H S A+ LP +IS G DGT+ IW + E T+ Sbjct: 216 QTKSCVATLEGHMSNVSFAVFHPTLPIIIS-GSEDGTLKIWNSST------YKVEKTLNV 268 Query: 149 GFFYPLCLSLSKVEEKKYL 167 G C++ K Y+ Sbjct: 269 GLERSWCIATHPTGRKNYI 287 Score = 35.4 bits (80), Expect = 0.097, Method: Compositional matrix adjust. Identities = 42/186 (22%), Positives = 76/186 (40%), Gaps = 18/186 (9%) Query: 556 GHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFS 615 H I + + P + + S + +++++ EN ++ H + + F+ Sbjct: 95 AHPDYIRSIAVHPTKPYVLSGS-----DDLTVKLWNWENNWALEQTFEGHEHFVMCVAFN 149 Query: 616 -KDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTAS 674 KD S C DR +W F L E+ + D+ PL +TAS Sbjct: 150 PKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYV----DYYPLPDKPYMITAS 205 Query: 675 RDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSY 734 D T+K+W +Q + LE H V+ H ++ I+IS G E+G + +++ Sbjct: 206 DDLTIKIWDYQTKSCVA-TLEG---HMSNVSFAVFHPTL---PIIIS-GSEDGTLKIWNS 257 Query: 735 TLGKFE 740 + K E Sbjct: 258 STYKVE 263 Score = 28.9 bits (63), Expect = 8.1, Method: Compositional matrix adjust. Identities = 16/40 (40%), Positives = 24/40 (60%), Gaps = 4/40 (10%) Query: 195 VAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWR 234 V + E H D+++S+A H P Y+L SGS D ++LW Sbjct: 90 VVDFEAHPDYIRSIAV-HPTKP--YVL-SGSDDLTVKLWN 125 >4J0W-A nrPDB Length = 343 Score = 49.3 bits (116), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 55/236 (23%), Positives = 95/236 (40%), Gaps = 36/236 (15%) Query: 550 EVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIR-------IFSTENWLEIKPAL 602 ++ L GH ITCL ++PD I SA + ++ + I + E KP Sbjct: 6 DIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKP-- 63 Query: 603 PFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWA 662 P HS + + S DGK+L S R + +WE + + + + A Sbjct: 64 PGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAV-------SGLA 116 Query: 663 PLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISV 722 + + S D++VKVW A++ +E H AV A+ D++ RE + + Sbjct: 117 FRRGTHQLYSTSHDRSVKVW----NVAENSYVETLFGHQDAVAAL---DALSRECCVTAG 169 Query: 723 GL----------ENGEIYLYSYTLGKFELITQLNED--ITPADKITRLRWSHLKRN 766 G E ++ Y + G + I +NE+ ++ AD + W K+ Sbjct: 170 GRDGTVRVWKIPEESQLVFYGHQ-GSIDCIHLINEEHMVSGADDGSVALWGLSKKR 224 Score = 39.7 bits (91), Expect = 0.005, Method: Compositional matrix adjust. Identities = 24/95 (25%), Positives = 45/95 (47%), Gaps = 5/95 (5%) Query: 54 TLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSAL 113 T GH V+ + F + + S S D VK+W + S+ ++T+ + + AL AL Sbjct: 104 TFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSY---VETLFGHQDAVAALDAL 160 Query: 114 P--SLISVGCADGTISIWRQNIQNDEFGLAHEFTI 146 ++ G DGT+ +W+ ++ H+ +I Sbjct: 161 SRECCVTAGGRDGTVRVWKIPEESQLVFYGHQGSI 195 Score = 37.0 bits (84), Expect = 0.030, Method: Compositional matrix adjust. Identities = 42/189 (22%), Positives = 70/189 (37%), Gaps = 52/189 (27%) Query: 54 TLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSAL 113 L+GH+ +TC+ PD + SA++D + W L I + ++ Sbjct: 9 VLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAE-------- 60 Query: 114 PSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGT 173 G G S + LC+++S + KYL A G Sbjct: 61 ------GKPPGHSS------------------------HVLCMAIS--SDGKYL-ASGDR 87 Query: 174 NVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW 233 + + I + C+ + GH D V LAFR G + L S S DR +++W Sbjct: 88 SKLILIWE-------AQSCQHLYTFTGHRDAVSGLAFRR----GTHQLYSTSHDRSVKVW 136 Query: 234 RIRINDLID 242 + N ++ Sbjct: 137 NVAENSYVE 145 Score = 28.9 bits (63), Expect = 8.2, Method: Compositional matrix adjust. Identities = 43/208 (20%), Positives = 88/208 (42%), Gaps = 24/208 (11%) Query: 36 KTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQ 95 +++ +W+ E TL GH+ V + + + + D V++WK + S L Sbjct: 131 RSVKVWNVAE---NSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL- 186 Query: 96 CIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQN------IQNDEFGLAHEFTIKKG 149 + S + L ++S G DG++++W + +Q + GL E +++ Sbjct: 187 -VFYGHQGSIDCIHLINEEHMVS-GADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQP 244 Query: 150 FFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLA 209 F+ +L + L+A G + V + G + ++ ++ ++ SL Sbjct: 245 FWISSVAALLNTD----LVATGSHSSCVRLWQ---CGEGFRQLDLLCDIP-LVGFINSLK 296 Query: 210 FRHQETPGDYLLCS-GSQDRYIRLWRIR 236 F + GD+L+ G + R R WRI+ Sbjct: 297 F---SSSGDFLVAGVGQEHRLGRWWRIK 321 >6MZM-G nrPDB Length = 800 Score = 49.3 bits (116), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 51/180 (28%), Positives = 73/180 (40%), Gaps = 25/180 (13%) Query: 56 KGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP- 114 KGH V +F P + VS D ++W TD H Q ++ + + P Sbjct: 582 KGHNYPVWDTQFSPYGYYFVSGGHDRVARLWA-TD--HYQPLRIFAGHLADVNCTRFHPN 638 Query: 115 -SLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGT 173 + ++ G AD T+ +W ++ N FT KG + L S LA G T Sbjct: 639 SNYVATGSADRTVRLW--DVLNGN--CVRIFTGHKGPIHSLTFS-----PNGRFLATGAT 689 Query: 174 NVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW 233 + V + I +V EL+GH D V SL F +L SGS D +RLW Sbjct: 690 DGRVLLWD-------IGHGLMVGELKGHTDTVCSLRFSRDGE----ILASGSMDNTVRLW 738 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 22/77 (28%), Positives = 41/77 (53%), Gaps = 5/77 (6%) Query: 55 LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP 114 GH A+V C RF P+S+++ + S D V++W D + C++ + I +L+ P Sbjct: 623 FAGHLADVNCTRFHPNSNYVATGSADRTVRLW---DVLNGNCVRIFTGHKGPIHSLTFSP 679 Query: 115 S--LISVGCADGTISIW 129 + ++ G DG + +W Sbjct: 680 NGRFLATGATDGRVLLW 696 Score = 40.8 bits (94), Expect = 0.003, Method: Compositional matrix adjust. Identities = 33/133 (24%), Positives = 52/133 (39%), Gaps = 25/133 (18%) Query: 556 GHGFEITCLDISPDQKLIASACRSNNVQ------NAVIRIFSTENWLEIKPALPFHSLTI 609 GH ++ C P+ +A+ V+ +RIF+ P HSLT Sbjct: 625 GHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKG-------PIHSLT- 676 Query: 610 TRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNV 669 FS +G+FL + D + LW D L K HT + ++ G + Sbjct: 677 ----FSPNGRFLATGATDGRVLLW-----DIGHGLMVGELKGHTDTVCSLRFS--RDGEI 725 Query: 670 FVTASRDKTVKVW 682 + S D TV++W Sbjct: 726 LASGSMDNTVRLW 738 Score = 34.3 bits (77), Expect = 0.24, Method: Compositional matrix adjust. Identities = 47/223 (21%), Positives = 84/223 (37%), Gaps = 33/223 (14%) Query: 198 LEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKL--TLLS 255 L GH V +F +P L S S+D +RLW ++ + + + + T S Sbjct: 539 LYGHSGPVYGASF----SPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFS 594 Query: 256 NKQYKFQIDDELRVGI-----NFEAL--IMGHDDWISSLQWHESRLQLLAATADTSLMVW 308 Y F RV +++ L GH ++ ++H + + +AD ++ +W Sbjct: 595 PYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLW 654 Query: 309 EPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWA 368 + ++ TG G S + + R F T G +W Sbjct: 655 D---------------VLNGNCVRIFTGHKGPIHSLTFSPNGR--FLATGATDGRVLLWD 697 Query: 369 TKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRL 411 ++ + + G T V + +S GE L + S+D T RL Sbjct: 698 IGHGLMVGE---LKGHTDTVCSLRFSRDGEILASGSMDNTVRL 737 Score = 32.3 bits (72), Expect = 0.88, Method: Compositional matrix adjust. Identities = 22/78 (28%), Positives = 40/78 (51%), Gaps = 5/78 (6%) Query: 336 GSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSP 395 G SG + F+ +R ++ L++ + G+ R+W+ + C +G G V D +SP Sbjct: 541 GHSGPVYGA-SFSPDR-NYLLSSSEDGTVRLWSLQ-TFTC--LVGYKGHNYPVWDTQFSP 595 Query: 396 SGEYLLATSLDQTTRLFA 413 G Y ++ D+ RL+A Sbjct: 596 YGYYFVSGGHDRVARLWA 613 Score = 32.0 bits (71), Expect = 1.0, Method: Compositional matrix adjust. Identities = 31/129 (24%), Positives = 54/129 (41%), Gaps = 13/129 (10%) Query: 554 LYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLK 613 LYGH + SPD+ + S+ ++ +R++S + + + H+ + + Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSS-----EDGTVRLWSLQTFTCLV-GYKGHNYPVWDTQ 592 Query: 614 FSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTA 673 FS G + +S DR LW D+ LR H + + P N T Sbjct: 593 FSPYGYYFVSGGHDRVARLW---ATDHYQPLRIF--AGHLADVNCTRFHP--NSNYVATG 645 Query: 674 SRDKTVKVW 682 S D+TV++W Sbjct: 646 SADRTVRLW 654 Score = 32.0 bits (71), Expect = 1.2, Method: Compositional matrix adjust. Identities = 23/84 (27%), Positives = 37/84 (44%), Gaps = 6/84 (7%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 V GH I L SP+ + +A+ V ++ + L + L H+ T+ Sbjct: 662 VRIFTGHKGPIHSLTFSPNGRFLATGATDGRV-----LLWDIGHGLMVG-ELKGHTDTVC 715 Query: 611 RLKFSKDGKFLLSVCRDRKWALWE 634 L+FS+DG+ L S D LW+ Sbjct: 716 SLRFSRDGEILASGSMDNTVRLWD 739 Score = 31.2 bits (69), Expect = 1.8, Method: Compositional matrix adjust. Identities = 13/32 (40%), Positives = 19/32 (59%) Query: 55 LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIW 86 LKGH V +RF D + + S S D+ V++W Sbjct: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738 >6F3T-A nrPDB Length = 608 Score = 49.3 bits (116), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 51/180 (28%), Positives = 73/180 (40%), Gaps = 25/180 (13%) Query: 56 KGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP- 114 KGH V +F P + VS D ++W TD H Q ++ + + P Sbjct: 390 KGHNYPVWDTQFSPYGYYFVSGGHDRVARLWA-TD--HYQPLRIFAGHLADVNCTRFHPN 446 Query: 115 -SLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGT 173 + ++ G AD T+ +W ++ N FT KG + L S LA G T Sbjct: 447 SNYVATGSADRTVRLW--DVLNGN--CVRIFTGHKGPIHSLTFS-----PNGRFLATGAT 497 Query: 174 NVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW 233 + V + I +V EL+GH D V SL F +L SGS D +RLW Sbjct: 498 DGRVLLWD-------IGHGLMVGELKGHTDTVCSLRFSRDGE----ILASGSMDNTVRLW 546 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 27/103 (26%), Positives = 50/103 (48%), Gaps = 8/103 (7%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 V+ G + LW ++A GH A+V C RF P+S+++ + S D V++W Sbjct: 408 FVSGGHDRVARLWATDHYQPLRIFA---GHLADVNCTRFHPNSNYVATGSADRTVRLW-- 462 Query: 89 TDYSHLQCIQTIQHYSKTIVALSALPS--LISVGCADGTISIW 129 D + C++ + I +L+ P+ ++ G DG + +W Sbjct: 463 -DVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLW 504 Score = 39.3 bits (90), Expect = 0.007, Method: Compositional matrix adjust. Identities = 33/133 (24%), Positives = 52/133 (39%), Gaps = 25/133 (18%) Query: 556 GHGFEITCLDISPDQKLIASACRSNNVQ------NAVIRIFSTENWLEIKPALPFHSLTI 609 GH ++ C P+ +A+ V+ +RIF+ P HSLT Sbjct: 433 GHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKG-------PIHSLT- 484 Query: 610 TRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNV 669 FS +G+FL + D + LW D L K HT + ++ G + Sbjct: 485 ----FSPNGRFLATGATDGRVLLW-----DIGHGLMVGELKGHTDTVCSLRFS--RDGEI 533 Query: 670 FVTASRDKTVKVW 682 + S D TV++W Sbjct: 534 LASGSMDNTVRLW 546 Score = 34.3 bits (77), Expect = 0.22, Method: Compositional matrix adjust. Identities = 41/179 (22%), Positives = 77/179 (43%), Gaps = 23/179 (12%) Query: 293 RLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERM 352 +L+ + +D SL+ E D+ V + E ++ G SG + F+ +R Sbjct: 311 KLRSVKQASDLSLIDKESDD-----VLERIMDEKTASELKILYGHSGPVYGA-SFSPDR- 363 Query: 353 DFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLF 412 ++ L++ + G+ R+W+ + C +G G V D +SP G Y ++ D+ RL Sbjct: 364 NYLLSSSEDGTVRLWSLQ-TFTC--LVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARL- 419 Query: 413 APWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFV-SGGDEKILRSFDLPKG 470 W D R A H D+ C ++ +V +G ++ +R +D+ G Sbjct: 420 --WATDHYQPLRIFAG---------HLADVNCTRFHPNSNYVATGSADRTVRLWDVLNG 467 Score = 33.5 bits (75), Expect = 0.33, Method: Compositional matrix adjust. Identities = 69/330 (20%), Positives = 122/330 (36%), Gaps = 65/330 (19%) Query: 91 YSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGF 150 Y+ L Q + T V ++ SLI+ G AD T+ +W T KK Sbjct: 272 YTFLNAYQGL-----TAVDVTDDSSLIAGGFADSTVRVW-------------SVTPKK-- 311 Query: 151 FYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAF 210 L V++ L I + +V I+ + + ++ L GH V +F Sbjct: 312 -------LRSVKQASDLSLIDKESDDVL--ERIMDEKTASELKI---LYGHSGPVYGASF 359 Query: 211 RHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKL--TLLSNKQYKFQIDDELR 268 +P L S S+D +RLW ++ + + + + T S Y F R Sbjct: 360 ----SPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDR 415 Query: 269 VGI-----NFEAL--IMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSL 321 V +++ L GH ++ ++H + + +AD ++ +W+ Sbjct: 416 VARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD------------ 463 Query: 322 RLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGI 381 ++ TG G S + + R F T G +W ++ + + Sbjct: 464 ---VLNGNCVRIFTGHKGPIHSLTFSPNGR--FLATGATDGRVLLWDIGHGLMVGE---L 515 Query: 382 SGATKDVTDIAWSPSGEYLLATSLDQTTRL 411 G T V + +S GE L + S+D T RL Sbjct: 516 KGHTDTVCSLRFSRDGEILASGSMDNTVRL 545 Score = 32.7 bits (73), Expect = 0.60, Method: Compositional matrix adjust. Identities = 32/133 (24%), Positives = 57/133 (42%), Gaps = 13/133 (9%) Query: 550 EVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTI 609 E++ LYGH + SPD+ + S+ ++ +R++S + + + H+ + Sbjct: 343 ELKILYGHSGPVYGASFSPDRNYLLSSS-----EDGTVRLWSLQTFTCLV-GYKGHNYPV 396 Query: 610 TRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNV 669 +FS G + +S DR LW D+ LR H + + P N Sbjct: 397 WDTQFSPYGYYFVSGGHDRVARLW---ATDHYQPLRIF--AGHLADVNCTRFHP--NSNY 449 Query: 670 FVTASRDKTVKVW 682 T S D+TV++W Sbjct: 450 VATGSADRTVRLW 462 Score = 31.6 bits (70), Expect = 1.4, Method: Compositional matrix adjust. Identities = 29/120 (24%), Positives = 41/120 (34%), Gaps = 40/120 (33%) Query: 7 PEAIFIGANKQTQVSDIHKVKKIVAFG-AGKTIALWDPIEPN-------NKG-------- 50 P IF G + H VA G A +T+ LWD + N +KG Sbjct: 427 PLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFS 486 Query: 51 ------------------------VYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIW 86 + LKGH V +RF D + + S S D+ V++W Sbjct: 487 PNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 546 Score = 31.2 bits (69), Expect = 2.0, Method: Compositional matrix adjust. Identities = 23/84 (27%), Positives = 37/84 (44%), Gaps = 6/84 (7%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 V GH I L SP+ + +A+ V ++ + L + L H+ T+ Sbjct: 470 VRIFTGHKGPIHSLTFSPNGRFLATGATDGRV-----LLWDIGHGLMVG-ELKGHTDTVC 523 Query: 611 RLKFSKDGKFLLSVCRDRKWALWE 634 L+FS+DG+ L S D LW+ Sbjct: 524 SLRFSRDGEILASGSMDNTVRLWD 547 >4V8M-A7 nrPDB Length = 318 Score = 48.9 bits (115), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 51/218 (23%), Positives = 94/218 (43%), Gaps = 32/218 (14%) Query: 28 KIVAFGAGKTIALWDPIEPNNKGVYAT-------LKGHEAEVTCVRFVPDSDFMVSASED 80 K+V+ KT+ W P P+ + L+GH A V+ V + +F VSAS D Sbjct: 30 KVVSTSRDKTLLSWGP-NPDRHSSECSYGLPDRRLEGHSAFVSDVALSNNGNFAVSASWD 88 Query: 81 HHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS--LISVGCADGTISIWRQNIQNDEF 138 H +++W + QC ++K +++++ P I G D + +W N++ + Sbjct: 89 HSLRLWNLQNG---QCQYKFLGHTKDVLSVAFSPDNRQIVSGGRDNALRVW--NVKGE-- 141 Query: 139 GLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTN-VNVFIASFILSDSGIEKCRVVAE 197 H + + C+ S + +++ G N V V+ + R+V + Sbjct: 142 -CMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVW---------DLATGRLVTD 191 Query: 198 LEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI 235 L+GH ++V S+ +P L S +D RLW + Sbjct: 192 LKGHTNYVTSVTV----SPDGSLCASSDKDGVARLWDL 225 Score = 41.2 bits (95), Expect = 0.002, Method: Compositional matrix adjust. Identities = 49/213 (23%), Positives = 88/213 (41%), Gaps = 38/213 (17%) Query: 269 VGINFEALIMGHDDWISSL---QWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGE 325 + + +E + GH W++SL Q E+ ++++ + D +L+ W P+ CS L + Sbjct: 1 MAVAYEGQLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPD 60 Query: 326 MSSKGAST-----ATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLG 380 +G S A ++G F + H + L NG+ C + Sbjct: 61 RRLEGHSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQ--------------CQYKF- 105 Query: 381 ISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGY 440 G TKDV +A+SP +++ D R +++ G H SR H Sbjct: 106 -LGHTKDVLSVAFSPDNRQIVSGGRDNALR-----VWNVKGE-----CMHTLSR-GAHTD 153 Query: 441 DMICVE---TVTDTRFVSGGDEKILRSFDLPKG 470 + CV ++ VSGG + +++ +DL G Sbjct: 154 WVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATG 186 Score = 33.9 bits (76), Expect = 0.29, Method: Compositional matrix adjust. Identities = 33/144 (22%), Positives = 61/144 (42%), Gaps = 14/144 (9%) Query: 602 LPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADW 661 L HS ++ + S +G F +S D LW N+++ + +F HT+ + + Sbjct: 63 LEGHSAFVSDVALSNNGNFAVSASWDHSLRLW--NLQNGQCQYKFLG---HTKDVLSVAF 117 Query: 662 APLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILIS 721 +P V+ RD ++VW + E A HT V+ + S+ +++S Sbjct: 118 SPDN--RQIVSGGRDNALRVWNVKGECMHTLSRGA---HTDWVSCVRFSPSL-DAPVIVS 171 Query: 722 VGLENGEIYLYSYTLGKFELITQL 745 G +N + + L L+T L Sbjct: 172 GGWDN---LVKVWDLATGRLVTDL 192 >5FVM-C nrPDB Length = 303 Score = 48.9 bits (115), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 64/265 (24%), Positives = 106/265 (40%), Gaps = 47/265 (17%) Query: 14 ANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDF 73 A+ Q +I KK +A + L+D I NN ++ +GH+ VT + F ++ + Sbjct: 31 ADSQVNRLEITSDKKYLAAAGHLHVRLYD-IRSNNPNPVSSFEGHKGNVTSIAFQQENRW 89 Query: 74 MVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS---LISVGCADGTISIW- 129 MVS+SED +K+W S +Q ++ + ++ P+ LIS DG I IW Sbjct: 90 MVSSSEDGTIKVWDVRSPS----VQRNYKHNAPVNEVAIHPNQGELISCD-QDGNIRIWD 144 Query: 130 ------------RQNIQNDEFGLAHEFTI-----KKGFFY----PLCLSLSKVE------ 162 N +A + ++ KG Y P S +E Sbjct: 145 LGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFK 204 Query: 163 -EKKY----LLAIGGTNVNVFIASFILSDSGIE-KCRVVAELEGHEDWVKSLAFRHQETP 216 KY LL+ N+ A IE ++ L+GH+ WV AF + Sbjct: 205 SHTKYITRVLLSADVKNLATCSADHTARVWNIEDNYQLETTLDGHQRWVWDCAF----SA 260 Query: 217 GDYLLCSGSQDRYIRLWRIRINDLI 241 L + D Y+RLW + ++++ Sbjct: 261 DSAYLVTACSDHYVRLWDLSTSEIV 285 Score = 35.4 bits (80), Expect = 0.10, Method: Compositional matrix adjust. Identities = 37/155 (23%), Positives = 67/155 (43%), Gaps = 20/155 (12%) Query: 549 PEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLT 608 P V++ Y H + + I P+Q + S + N++ + N L + P SL+ Sbjct: 107 PSVQRNYKHNAPVNEVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLS 166 Query: 609 ITRLKFSKDGKFLLSVCRDRKWALWE--RNMEDNTFE--LRFKNEKPH-TRIIWDADWAP 663 + + DG L++ +W + + +T E +FK+ + TR++ AD Sbjct: 167 V-----ASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKN 221 Query: 664 LEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASI 698 L T S D T +VW + D+Y LE ++ Sbjct: 222 L------ATCSADHTARVWNIE----DNYQLETTL 246 Score = 32.3 bits (72), Expect = 0.72, Method: Compositional matrix adjust. Identities = 22/84 (26%), Positives = 41/84 (48%), Gaps = 5/84 (5%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 V K H IT + +S D K +A+ C +++ R+++ E+ +++ L H + Sbjct: 200 VTKFKSHTKYITRVLLSADVKNLAT-CSADHTA----RVWNIEDNYQLETTLDGHQRWVW 254 Query: 611 RLKFSKDGKFLLSVCRDRKWALWE 634 FS D +L++ C D LW+ Sbjct: 255 DCAFSADSAYLVTACSDHYVRLWD 278 Score = 29.3 bits (64), Expect = 6.6, Method: Compositional matrix adjust. Identities = 26/88 (29%), Positives = 46/88 (52%), Gaps = 12/88 (13%) Query: 670 FVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEI 729 V++S D T+KVW + P+ ++ + KH V ++IH + + LIS ++G I Sbjct: 90 MVSSSEDGTIKVWD-VRSPS----VQRNYKHNAPVNEVAIHPN---QGELISCD-QDGNI 140 Query: 730 YLYSYTLGKFELITQLN-EDITPADKIT 756 ++ LG+ + QL ED TP ++ Sbjct: 141 RIWD--LGENQCTNQLTPEDNTPLQSLS 166 >4YCZ-A nrPDB Length = 876 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 54/222 (24%), Positives = 95/222 (42%), Gaps = 20/222 (9%) Query: 27 KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPD--SDFMVSASEDHHVK 84 +++ + +TI +++ IE + + TLKGH+ V CV + + + SA D V Sbjct: 31 RRLATCSSDRTIKIFE-IEGETQRLTETLKGHDGAVWCVSWAHPKYGNILASAGYDGKVL 89 Query: 85 IWKFTDYSHLQCIQTIQH-YSKTIVALSALPSLISVGCA--DGTISI--WRQNIQNDEFG 139 IW+ + + + H S +V+ S + + CA DG +S+ +R N Sbjct: 90 IWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNVSVLEFRDNSWEHSIF 149 Query: 140 LAHEFTIKKGFFYPLCLSLSKVEEK-------KYLLAIGGTNVNVFIASFILSDSGIEKC 192 AH + + P S V K GG++ + I ++ D Sbjct: 150 HAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNALKIWAY---DPATNTY 206 Query: 193 RVVAE-LEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW 233 ++ E L GH DWV+ +A+ Y + S S+DR +R+W Sbjct: 207 KLEREPLTGHTDWVRDVAWSPTVLQKSY-IASASEDRTVRIW 247 Score = 38.9 bits (89), Expect = 0.009, Method: Compositional matrix adjust. Identities = 27/117 (23%), Positives = 54/117 (46%), Gaps = 7/117 (5%) Query: 27 KKIVAFGAGKTIALW--DPIEPNNKGVYATLKGHEAEVTCVRFVP---DSDFMVSASEDH 81 ++ V G+ + +W DP K L GH V V + P ++ SASED Sbjct: 183 RRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDR 242 Query: 82 HVKIWKFTDYSHLQCIQTIQHYSKTI--VALSALPSLISVGCADGTISIWRQNIQND 136 V+IW + LQ + ++ + V+ S ++++ D +++W++N++ + Sbjct: 243 TVRIWTSDPANPLQWNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVTLWKENLKGE 299 Score = 33.1 bits (74), Expect = 0.53, Method: Compositional matrix adjust. Identities = 20/63 (31%), Positives = 34/63 (53%), Gaps = 5/63 (7%) Query: 355 FLTNGKTGSWRMWA--TKDNIICDQRLGISGATKDVTDIAWSPS---GEYLLATSLDQTT 409 F+T G + ++WA N +R ++G T V D+AWSP+ Y+ + S D+T Sbjct: 185 FVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTV 244 Query: 410 RLF 412 R++ Sbjct: 245 RIW 247 Score = 32.7 bits (73), Expect = 0.71, Method: Compositional matrix adjust. Identities = 20/66 (30%), Positives = 32/66 (48%), Gaps = 3/66 (4%) Query: 618 GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDK 677 G+ L + DR ++E +E T L + K H +W WA ++GN+ +A D Sbjct: 30 GRRLATCSSDRTIKIFE--IEGETQRLT-ETLKGHDGAVWCVSWAHPKYGNILASAGYDG 86 Query: 678 TVKVWR 683 V +WR Sbjct: 87 KVLIWR 92 Score = 32.3 bits (72), Expect = 0.75, Method: Compositional matrix adjust. Identities = 16/57 (28%), Positives = 29/57 (50%), Gaps = 1/57 (1%) Query: 627 DRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFV-TASRDKTVKVW 682 D +W + NT++L + HT + D W+P ++ +AS D+TV++W Sbjct: 191 DNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIW 247 Score = 29.6 bits (65), Expect = 5.2, Method: Compositional matrix adjust. Identities = 13/49 (26%), Positives = 26/49 (53%), Gaps = 4/49 (8%) Query: 277 IMGHDDWISSLQWHESRLQ---LLAATADTSLMVWEPDETSGI-WVCSL 321 + GH DW+ + W + LQ + +A+ D ++ +W D + + W C + Sbjct: 213 LTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPANPLQWNCKV 261 >6EMK-B nrPDB Length = 303 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 62/272 (22%), Positives = 102/272 (37%), Gaps = 61/272 (22%) Query: 14 ANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDF 73 ++ Q +I KK++A + + L+D I N A+ +GH VT V F D+ + Sbjct: 31 SDSQVNRLEITNDKKLLATAGHQNVRLYD-IRTTNPNPVASFEGHRGNVTSVSFQQDNRW 89 Query: 74 MVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKT--IVALSALPSLISVGCADGTISIWRQ 131 MV++SED +K+W D + +H + +V LIS DG I IW Sbjct: 90 MVTSSEDGTIKVW---DVRSPSIPRNYKHNAPVNEVVIHPNQGELISCD-RDGNIRIWDL 145 Query: 132 NIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFI------------ 179 E H+ T + SLS + +LA T N ++ Sbjct: 146 G----ENQCTHQLTPEDDTSLQ---SLSMASDGS-MLAAANTKGNCYVWEMPNHTDASHL 197 Query: 180 ------------ASFILSDSGIEKC------------------RVVAELEGHEDWVKSLA 209 + IL S ++ ++ L+GH+ WV A Sbjct: 198 KPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCA 257 Query: 210 FRHQETPGDYLLCSGSQDRYIRLWRIRINDLI 241 F + L + S D Y+RLW + +++ Sbjct: 258 F----SADSAYLVTASSDHYVRLWDLSTREIV 285 Score = 35.8 bits (81), Expect = 0.073, Method: Compositional matrix adjust. Identities = 38/140 (27%), Positives = 60/140 (42%), Gaps = 16/140 (11%) Query: 545 HLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPF 604 H L PE + + L ++ D ++A+A N V + + + +KP F Sbjct: 152 HQLTPEDDT------SLQSLSMASDGSMLAAANTKGNCY--VWEMPNHTDASHLKPVTKF 203 Query: 605 --HSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWA 662 HS ITR+ S D K L + D +W D+ F+L + H R +WD ++ Sbjct: 204 RAHSTYITRILLSSDVKHLATCSADHTARVWS---IDDDFKLETTLDG-HQRWVWDCAFS 259 Query: 663 PLEFGNVFVTASRDKTVKVW 682 VTAS D V++W Sbjct: 260 A--DSAYLVTASSDHYVRLW 277 Score = 31.6 bits (70), Expect = 1.4, Method: Compositional matrix adjust. Identities = 36/155 (23%), Positives = 58/155 (37%), Gaps = 20/155 (12%) Query: 549 PEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLT 608 P + + Y H + + I P+Q + S R N IRI+ P + Sbjct: 107 PSIPRNYKHNAPVNEVVIHPNQGELISCDRDGN-----IRIWDLGENQCTHQLTPEDDTS 161 Query: 609 ITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFEL----RFKNEKPH-TRIIWDADWAP 663 + L + DG L + +WE + L +F+ + TRI+ +D Sbjct: 162 LQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKH 221 Query: 664 LEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASI 698 L T S D T +VW DD+ LE ++ Sbjct: 222 L------ATCSADHTARVW----SIDDDFKLETTL 246 >5I2T-A nrPDB Length = 742 Score = 47.0 bits (110), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 52/226 (23%), Positives = 102/226 (45%), Gaps = 25/226 (11%) Query: 12 IGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDS 71 +G N VS +++ + +AFG+ K L E ++ +GH + + PD Sbjct: 325 MGQNPVNTVS-VNQTGEWLAFGSSKLGQLL-VYEWQSESYILKQQGHFDSTNSLAYSPDG 382 Query: 72 DFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVAL--SALPSLISVGCADGTISIW 129 +V+ASED +K+W D + C+ T + ++ ++ A+ + ++ DGT+ W Sbjct: 383 SRVVTASEDGKIKVW---DITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAW 439 Query: 130 RQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGI 189 I+ F FT + + CL++ E ++ +++V+ + Sbjct: 440 DL-IRYRNF---RTFTGTERIQFN-CLAVDPSGEVVCAGSLDNFDIHVW---------SV 485 Query: 190 EKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI 235 + +++ L GHE V L+F + + +L S S D+ IR+W I Sbjct: 486 QTGQLLDALSGHEGPVSCLSFSQENS----VLASASWDKTIRIWSI 527 Score = 42.7 bits (99), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 26/77 (33%), Positives = 42/77 (54%), Gaps = 5/77 (6%) Query: 55 LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP 114 L GHE V+C+ F ++ + SAS D ++IW + Q ++ I+ YS ++ALS P Sbjct: 494 LSGHEGPVSCLSFSQENSVLASASWDKTIRIWSI--FGRSQQVEPIEVYSD-VLALSMRP 550 Query: 115 --SLISVGCADGTISIW 129 ++V G ISI+ Sbjct: 551 DGKEVAVSTLKGQISIF 567 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 58/237 (24%), Positives = 94/237 (39%), Gaps = 51/237 (21%) Query: 554 LYGHGFEITC--LDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPF------- 604 L+ F+ C + SPD +L A A ++I+ T + + + PF Sbjct: 115 LHHFNFKEKCSAVKFSPDGRLFALAS------GRFLQIWKTPDVNKDRQFAPFVRHRVHA 168 Query: 605 -HSLTITRLKFSKDGKFLLSVCRDRKWALW-----ERNMEDNTFELRFKNEKPHTRIIWD 658 H IT L +S+D +F+L+ +D +W E+N+ TF H + Sbjct: 169 GHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTF-------NGHRDYVMG 221 Query: 659 ADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREK- 717 A ++ + T S+D V VW K P+DD E+ + IS + I +K Sbjct: 222 AFFSHDQ--EKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKH 279 Query: 718 ------------------ILISVGLENGEIYLYSYTLGKFELITQLNEDITPADKIT 756 L++VG +GE LY L F LI QL+ P + ++ Sbjct: 280 FFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYD--LPDFTLIQQLSMGQNPVNTVS 334 Score = 32.3 bits (72), Expect = 0.87, Method: Compositional matrix adjust. Identities = 16/65 (24%), Positives = 32/65 (49%), Gaps = 6/65 (9%) Query: 28 KIVAFGAGKTIALWDPIEPNNKGVYATL------KGHEAEVTCVRFVPDSDFMVSASEDH 81 ++ A +G+ + +W + N +A GH ++T + + DS F+++ S+D Sbjct: 134 RLFALASGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDL 193 Query: 82 HVKIW 86 KIW Sbjct: 194 SAKIW 198 >5WLC-LO nrPDB Length = 923 Score = 47.0 bits (110), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 52/226 (23%), Positives = 102/226 (45%), Gaps = 25/226 (11%) Query: 12 IGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDS 71 +G N VS +++ + +AFG+ K L E ++ +GH + + PD Sbjct: 300 MGQNPVNTVS-VNQTGEWLAFGSSKLGQLL-VYEWQSESYILKQQGHFDSTNSLAYSPDG 357 Query: 72 DFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVAL--SALPSLISVGCADGTISIW 129 +V+ASED +K+W D + C+ T + ++ ++ A+ + ++ DGT+ W Sbjct: 358 SRVVTASEDGKIKVW---DITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAW 414 Query: 130 RQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGI 189 I+ F FT + + CL++ E ++ +++V+ + Sbjct: 415 DL-IRYRNF---RTFTGTERIQFN-CLAVDPSGEVVCAGSLDNFDIHVW---------SV 460 Query: 190 EKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI 235 + +++ L GHE V L+F + + +L S S D+ IR+W I Sbjct: 461 QTGQLLDALSGHEGPVSCLSFSQENS----VLASASWDKTIRIWSI 502 Score = 42.7 bits (99), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 26/77 (33%), Positives = 42/77 (54%), Gaps = 5/77 (6%) Query: 55 LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP 114 L GHE V+C+ F ++ + SAS D ++IW + Q ++ I+ YS ++ALS P Sbjct: 469 LSGHEGPVSCLSFSQENSVLASASWDKTIRIWSI--FGRSQQVEPIEVYSD-VLALSMRP 525 Query: 115 --SLISVGCADGTISIW 129 ++V G ISI+ Sbjct: 526 DGKEVAVSTLKGQISIF 542 Score = 39.7 bits (91), Expect = 0.005, Method: Compositional matrix adjust. Identities = 58/237 (24%), Positives = 94/237 (39%), Gaps = 51/237 (21%) Query: 554 LYGHGFEITC--LDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPF------- 604 L+ F+ C + SPD +L A A ++I+ T + + + PF Sbjct: 90 LHHFNFKEKCSAVKFSPDGRLFALAS------GRFLQIWKTPDVNKDRQFAPFVRHRVHA 143 Query: 605 -HSLTITRLKFSKDGKFLLSVCRDRKWALW-----ERNMEDNTFELRFKNEKPHTRIIWD 658 H IT L +S+D +F+L+ +D +W E+N+ TF H + Sbjct: 144 GHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTF-------NGHRDYVMG 196 Query: 659 ADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREK- 717 A ++ + T S+D V VW K P+DD E+ + IS + I +K Sbjct: 197 AFFSHDQ--EKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKH 254 Query: 718 ------------------ILISVGLENGEIYLYSYTLGKFELITQLNEDITPADKIT 756 L++VG +GE LY L F LI QL+ P + ++ Sbjct: 255 FFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYD--LPDFTLIQQLSMGQNPVNTVS 309 Score = 32.0 bits (71), Expect = 1.1, Method: Compositional matrix adjust. Identities = 16/65 (24%), Positives = 32/65 (49%), Gaps = 6/65 (9%) Query: 28 KIVAFGAGKTIALWDPIEPNNKGVYATL------KGHEAEVTCVRFVPDSDFMVSASEDH 81 ++ A +G+ + +W + N +A GH ++T + + DS F+++ S+D Sbjct: 109 RLFALASGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDL 168 Query: 82 HVKIW 86 KIW Sbjct: 169 SAKIW 173 >5FL8-q nrPDB Length = 515 Score = 46.2 bits (108), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 81/408 (19%), Positives = 160/408 (39%), Gaps = 67/408 (16%) Query: 24 HKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHV 83 H ++V T +WD + + TLKGH V CV + PD + + + S D+ + Sbjct: 154 HTSSRMVTGAGDNTARIWDC---DTQTPMHTLKGHYNWVLCVSWSPDGEVIATGSMDNTI 210 Query: 84 KIWKFTDYSHLQCI-QTIQHYSKTIVALSALP-SLISVG--------CADGTISIWRQNI 133 ++W D QC+ ++ +SK I +LS P L+ G DGTI IW Sbjct: 211 RLW---DPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIW---- 263 Query: 134 QNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCR 193 D ++T+ C+ + LL G + V + + ++ G R Sbjct: 264 --DTVSRVCQYTMSGHTNSVSCVKWG----GQGLLYSGSHDRTVRV--WDINSQG----R 311 Query: 194 VVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRY---------IRLWRIRINDLIDDS 244 + L+ H WV L+ DY L G+ D + + + I Sbjct: 312 CINILKSHAHWVNHLSLS-----TDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKK 366 Query: 245 EEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTS 304 +S+++ + ++ Y + + L+ A + GH ++ + + +++A+ D S Sbjct: 367 NGNSEEMMVTASDDYTMFLWNPLK-STKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNS 425 Query: 305 LMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSW 364 + +W D G ++ + R G + W + R+ ++ K + Sbjct: 426 IKLW--DGRDGKFISTFR-------------GHVASVYQVAWSSDCRL--LVSCSKDTTL 468 Query: 365 RMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLF 412 ++W + + + + G +V + WS G+ + + D+ RL+ Sbjct: 469 KVWDVRTRKL---SVDLPGHKDEVYTVDWSVDGKRVCSGGKDKMVRLW 513 Score = 39.3 bits (90), Expect = 0.007, Method: Compositional matrix adjust. Identities = 80/409 (19%), Positives = 148/409 (36%), Gaps = 83/409 (20%) Query: 331 ASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRL---GISGATKD 387 +S+A G C F +T + R+W CD + + G Sbjct: 135 SSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWD------CDTQTPMHTLKGHYNW 188 Query: 388 VTDIAWSPSGEYLLATSLDQTTRLFAP---------------WIYDAS---------GRK 423 V ++WSP GE + S+D T RL+ P WI S G K Sbjct: 189 VLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSK 248 Query: 424 REIAT---------WHEFSRP-----QIHGYDMICVETVTDTRFVSGGDEKILRSFDL-P 468 +A+ W SR H + CV+ SG ++ +R +D+ Sbjct: 249 PRLASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQGLLYSGSHDRTVRVWDINS 308 Query: 469 KGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEG---------- 518 +G + K S D A +G + G+ + ++ +++ Sbjct: 309 QGRCINILKSHAHWVNHLSLSTDYALR--IGAFDHTGKKPSTPEEAQKKALENYEKICKK 366 Query: 519 -GNKETPDIT--DPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIAS 575 GN E +T D ++ P++ + ++ GH + + SPD + I S Sbjct: 367 NGNSEEMMVTASDDYTMFLWNPLKST-------KPIARMTGHQKLVNHVAFSPDGRYIVS 419 Query: 576 ACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWER 635 A N+ I+++ + I H ++ ++ +S D + L+S +D +W+ Sbjct: 420 ASFDNS-----IKLWDGRDGKFIS-TFRGHVASVYQVAWSSDCRLLVSCSKDTTLKVWDV 473 Query: 636 NMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRH 684 + +L ++ +T + W D G + +DK V++W H Sbjct: 474 RTRKLSVDLPGHKDEVYT-VDWSVD------GKRVCSGGKDKMVRLWTH 515 >5OPT-p nrPDB Length = 318 Score = 45.1 bits (105), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 45/186 (24%), Positives = 82/186 (44%), Gaps = 28/186 (15%) Query: 55 LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP 114 L+GH A V+ V + DF VSAS DH +++W C ++K +++++ P Sbjct: 63 LEGHSAFVSDVALSNNGDFAVSASWDHSLRLWNLQTGV---CQHKFLGHTKDVLSVTFSP 119 Query: 115 S--LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFF--YPLCLSLSKVEEKKYLLAI 170 I G D + +W N++ + T+ +G + C+ S E +++ Sbjct: 120 DNRQIVSGGRDNALRVW--NVKGECL-----HTLGRGAHTDWVSCVRFSPSLETPLIVSG 172 Query: 171 GGTN-VNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRY 229 G N V V+ I R++ +L+GH +++ S+ +P L S +D Sbjct: 173 GWDNLVKVW---------DIASGRLLTDLKGHTNYITSVTV----SPDGSLCASSDKDGV 219 Query: 230 IRLWRI 235 RLW + Sbjct: 220 ARLWDL 225 Score = 33.5 bits (75), Expect = 0.35, Method: Compositional matrix adjust. Identities = 31/147 (21%), Positives = 64/147 (43%), Gaps = 14/147 (9%) Query: 269 VGINFEALIMGHDDWISSL---QWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGE 325 + + +E + GH W+++L Q E+ ++ ++ + D +L+ W + C E Sbjct: 1 MAVVYEGQLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPE 60 Query: 326 MSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGAT 385 +G S F S + ++ DF ++ S R+W + + C + G T Sbjct: 61 RRLEGHS-------AFVSDVALSNNG-DFAVSASWDHSLRLWNLQTGV-CQHKF--LGHT 109 Query: 386 KDVTDIAWSPSGEYLLATSLDQTTRLF 412 KDV + +SP +++ D R++ Sbjct: 110 KDVLSVTFSPDNRQIVSGGRDNALRVW 136 Score = 31.2 bits (69), Expect = 1.8, Method: Compositional matrix adjust. Identities = 43/194 (22%), Positives = 73/194 (37%), Gaps = 29/194 (14%) Query: 539 EDQLQRHLLW------PEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFST 592 E QL+ H W P++ + Y I + S D LIA + F Sbjct: 6 EGQLKGHRGWVTALACPQITETY-----IKAVSTSRDNTLIAWGSNMDRNSEECEYGFPE 60 Query: 593 ENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPH 652 L HS ++ + S +G F +S D LW N++ + +F H Sbjct: 61 RR-------LEGHSAFVSDVALSNNGDFAVSASWDHSLRLW--NLQTGVCQHKFLG---H 108 Query: 653 TRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDS 712 T+ + ++P V+ RD ++VW + E A HT V+ + S Sbjct: 109 TKDVLSVTFSPDN--RQIVSGGRDNALRVWNVKGECLHTLGRGA---HTDWVSCVRFSPS 163 Query: 713 MIREKILISVGLEN 726 + +++S G +N Sbjct: 164 L-ETPLIVSGGWDN 176 >6GMH-W nrPDB Length = 305 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 47/189 (24%), Positives = 84/189 (44%), Gaps = 25/189 (13%) Query: 54 TLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSAL 113 +L+GH+ V V S+S D H+++W + ++ I + T+ A S Sbjct: 59 SLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTL-AFSPD 117 Query: 114 PSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLL--AIG 171 ++ G G ++I+ E+ L +G F LS++ + KYL AI Sbjct: 118 SQYLATGTHVGKVNIFGVESGKKEYSLD-----TRGKF---ILSIAYSPDGKYLASGAID 169 Query: 172 GTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIR 231 G +N+F I +++ LEGH ++SL F +P LL + S D YI+ Sbjct: 170 GI-INIF---------DIATGKLLHTLEGHAMPIRSLTF----SPDSQLLVTASDDGYIK 215 Query: 232 LWRIRINDL 240 ++ ++ +L Sbjct: 216 IYDVQHANL 224 Score = 38.5 bits (88), Expect = 0.013, Method: Compositional matrix adjust. Identities = 28/87 (32%), Positives = 36/87 (41%), Gaps = 11/87 (12%) Query: 640 NTFELRFKNEKPHTRIIWDADWA--PLEFGNVFVTASRDKTVKVWRHQKEPADDY----- 692 N + + FK E+ H IW W E VT S D VKVW+ + E D Sbjct: 3 NQYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEG 62 Query: 693 ----VLEASIKHTKAVTAISIHDSMIR 715 V+ I HT + A S D+ IR Sbjct: 63 HQLGVVSVDISHTLPIAASSSLDAHIR 89 Score = 37.7 bits (86), Expect = 0.019, Method: Compositional matrix adjust. Identities = 18/61 (29%), Positives = 34/61 (55%), Gaps = 3/61 (4%) Query: 54 TLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSAL 113 TL+GH + + F PDS +V+AS+D ++KI+ D H T+ ++ ++ ++ Sbjct: 185 TLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIY---DVQHANLAGTLSGHASWVLNVAFC 241 Query: 114 P 114 P Sbjct: 242 P 242 >5OQL-J nrPDB Length = 912 Score = 44.7 bits (104), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 48/188 (25%), Positives = 85/188 (45%), Gaps = 20/188 (10%) Query: 64 CVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP--SLISVGC 121 V F+ + +M SA ++IW T + + Q + + I++ +LP SLI Sbjct: 279 SVGFLNEGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILCAQ 338 Query: 122 ADGTISIWR----QNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNV 177 AD T+ ++R ++ + G+ E + + L L+ + + ++AI + ++ Sbjct: 339 ADFTLVLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDI 398 Query: 178 FIASFILSDSGIE---KCRV-------VAELEGHEDWVKSLAFRHQETPGDYLLCSGSQD 227 I S + + E +CR VA L+GHED V SL + + SGS+D Sbjct: 399 RIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWS----GHWIASGSKD 454 Query: 228 RYIRLWRI 235 RLWR+ Sbjct: 455 NTARLWRV 462 Score = 38.1 bits (87), Expect = 0.015, Method: Compositional matrix adjust. Identities = 28/114 (24%), Positives = 52/114 (45%), Gaps = 21/114 (18%) Query: 12 IGANKQTQVSDIHKVKKIVAFGA-GKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVP- 69 + +K DI K+ A + KT+ +WD + +G+ L+GH+ V VRF P Sbjct: 541 LAHDKDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGI---LRGHKRGVWTVRFAPL 597 Query: 70 -------------DSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVAL 110 +++ S D +K+W +DY+ CI+T + +S ++ + Sbjct: 598 NTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYT---CIRTFEGHSHNVLKV 648 Score = 35.4 bits (80), Expect = 0.085, Method: Compositional matrix adjust. Identities = 67/308 (21%), Positives = 125/308 (40%), Gaps = 44/308 (14%) Query: 38 IALWDPIEPNNKGVYATLK----GHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSH 93 I ++D + VYA K HE+ V C+ + P+ ++S S D + +W + D Sbjct: 207 IRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLWLWRD-GI 265 Query: 94 LQCIQTIQH-YSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFY 152 Q ++H +++ L+ + S G + G + IW HE T K+ Sbjct: 266 WQGTPMLRHELLESVGFLNEGKWMYSAGTS-GVLRIWDTTTH-------HEITKKQD--- 314 Query: 153 PLCLSLSKVEEKKYLLAIGGTNVNVFI---ASFILSDSGIEKCRVVAELEGHEDWVKSLA 209 +K E + L A+ ++ + A F L + + A++ + + Sbjct: 315 ------AKSEGEAILSAVSLPERSLILCAQADFTLV---LYRVPSPADVVSSSEGILLEP 365 Query: 210 FRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDD--EL 267 FR SG+ D + L I + + +S+ + ++S K + +D E Sbjct: 366 FRR---------ISGTHDEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAEC 416 Query: 268 RVGINFE---ALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVC-SLRL 323 R G F AL+ GH+D + SL S + + + D + +W D + + C ++ Sbjct: 417 RSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYTCYAVFT 476 Query: 324 GEMSSKGA 331 G + S GA Sbjct: 477 GHLESVGA 484 Score = 35.0 bits (79), Expect = 0.12, Method: Compositional matrix adjust. Identities = 42/160 (26%), Positives = 68/160 (42%), Gaps = 26/160 (16%) Query: 541 QLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKP 600 QLQ+ + H +I LDISP+ KL ASA Q+ ++I+ E LE++ Sbjct: 527 QLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASAS-----QDKTVKIWDVEK-LEVQG 580 Query: 601 ALPFHSLTITRLKF-------------SKDGK-FLLSVCRDRKWALWERNMEDNTFELRF 646 L H + ++F S G+ +L+ D+ LW N+ D T F Sbjct: 581 ILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLW--NLSDYTCIRTF 638 Query: 647 KNEKPHT-RIIW---DADWAPLEFGNVFVTASRDKTVKVW 682 + + +++W D + + F +A D VKVW Sbjct: 639 EGHSHNVLKVVWLHISRDDSITKTKVQFASAGADTLVKVW 678 Score = 32.3 bits (72), Expect = 0.85, Method: Compositional matrix adjust. Identities = 49/240 (20%), Positives = 90/240 (37%), Gaps = 47/240 (19%) Query: 28 KIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWK 87 +I+A G+ L E N A ++G ++ + P ++ S ++I+ Sbjct: 33 RILASTLGENAIL---TELNTGKRLAEIQGDGEPISTLTITPSGSHLIVCSRSLTMRIYS 89 Query: 88 FT---DYSHLQ--CIQTIQHYSKTIVALSA--LPSLISVGCADGTISIWRQNIQNDEFGL 140 DY ++ ++T + ++ +V L+ +L++ G ADG I IW D G Sbjct: 90 LAISPDYDSVEPTLVRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIW------DIIGG 143 Query: 141 AHEFTIKKG--------FFYPLCLSLSKVEEKK-------------------YLLAIGGT 173 T+ FF + S+ KK + LA G Sbjct: 144 YVTHTVSGPSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQ 203 Query: 174 NVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW 233 + + I + + E HE V+ +A+ +P + L SGS+D+ + LW Sbjct: 204 DGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAY----SPEQHALLSGSRDKTMTLW 259 Score = 31.2 bits (69), Expect = 1.7, Method: Compositional matrix adjust. Identities = 44/199 (22%), Positives = 77/199 (38%), Gaps = 40/199 (20%) Query: 57 GHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP-- 114 H+ ++ + P+ SAS+D VKIW D L+ ++ + + + + P Sbjct: 542 AHDKDINALDISPNGKLFASASQDKTVKIW---DVEKLEVQGILRGHKRGVWTVRFAPLN 598 Query: 115 --------------SLISVGCADGTISIWRQN----IQNDEFGLAHEFTIKKGFFYPLCL 156 ++ G D TI +W + I+ E H + K + + Sbjct: 599 TPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFE---GHSHNVLKVVWLHISR 655 Query: 157 SLSKVEEKKYLLAIGG-TNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQET 215 S + K + G T V V+ A ++G +C L+ HED + +LA H +T Sbjct: 656 DDSITKTKVQFASAGADTLVKVWDA-----NTGETEC----TLDNHEDRLWTLAV-HSKT 705 Query: 216 PGDYLLCSGSQDRYIRLWR 234 +L S D + WR Sbjct: 706 ---NILASAGSDSKVTFWR 721 Score = 29.6 bits (65), Expect = 5.3, Method: Compositional matrix adjust. Identities = 35/143 (24%), Positives = 57/143 (39%), Gaps = 36/143 (25%) Query: 189 IEKCRVVAELEGHEDWVKSLAFRHQETP----------GDYLLCSGSQDRYIRLWRIRIN 238 +EK V L GH+ V ++ F TP G ++ +GS D+ I+LW + Sbjct: 573 VEKLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDY 632 Query: 239 DLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLA 298 I E S + + L + DD I+ ++++Q + Sbjct: 633 TCIRTFEGHSHNV-------------------LKVVWLHISRDDSIT-----KTKVQFAS 668 Query: 299 ATADTSLMVWEPDETSGIWVCSL 321 A ADT + VW D +G C+L Sbjct: 669 AGADTLVKVW--DANTGETECTL 689 Score = 29.3 bits (64), Expect = 7.8, Method: Compositional matrix adjust. Identities = 15/36 (41%), Positives = 22/36 (61%), Gaps = 3/36 (8%) Query: 654 RIIWDADWAPLEF---GNVFVTASRDKTVKVWRHQK 686 R+ D D L+ G +F +AS+DKTVK+W +K Sbjct: 540 RLAHDKDINALDISPNGKLFASASQDKTVKIWDVEK 575 >4BTS-AR nrPDB Length = 343 Score = 44.7 bits (104), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 53/238 (22%), Positives = 95/238 (39%), Gaps = 47/238 (19%) Query: 198 LEGHEDWVKSL--AFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLT--- 252 LEGH DWV S+ F +E +L SGS+D+ + +W++ + K LT Sbjct: 17 LEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHN 76 Query: 253 -----LLSNKQYKFQIDD---------ELRVGINFEALIMGHDDWISSLQWHESRLQLLA 298 L +++ F I +LR G ++ + GH + S+ + Q+L+ Sbjct: 77 HFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFV-GHQSEVYSVAFSPDNRQILS 135 Query: 299 ATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFT---------H 349 A A+ + +W LGE K +S + + SC+ ++ Sbjct: 136 AGAEREIKLWNI------------LGEC--KFSSAEKENHSDWVSCVRYSPIMKSANKVQ 181 Query: 350 ERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQ 407 +F + G G ++W T I R +V ++ SP+G+Y+ D+ Sbjct: 182 PFAPYFASVGWDGRLKVWNTNFQI----RYTFKAHESNVNHLSISPNGKYIATGGKDK 235 Score = 43.1 bits (100), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 41/156 (26%), Positives = 61/156 (39%), Gaps = 26/156 (16%) Query: 36 KTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQ 95 KT+ LWD Y GH++EV V F PD+ ++SA + +K+W Sbjct: 98 KTLRLWDL---RTGTTYKRFVGHQSEVYSVAFSPDNRQILSAGAEREIKLWNILGECKFS 154 Query: 96 CIQTIQH--------YSKTIVALSAL----PSLISVGCADGTISIWRQNIQNDEFGLAHE 143 + H YS + + + + P SVG DG + +W N Q AHE Sbjct: 155 SAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGW-DGRLKVWNTNFQIRYTFKAHE 213 Query: 144 FTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFI 179 + LS KY +A GG + + I Sbjct: 214 SNVNH---------LSISPNGKY-IATGGKDKKLLI 239 >6HQA-B nrPDB Length = 722 Score = 43.9 bits (102), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 28/95 (29%), Positives = 45/95 (47%), Gaps = 10/95 (10%) Query: 42 DPI-EPNNKGVYAT----LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQC 96 DP + NN GV L GH V V F PD+ +++S SED V++W Y+ C Sbjct: 431 DPYNQQNNDGVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYT---C 487 Query: 97 IQTIQHYSKTI--VALSALPSLISVGCADGTISIW 129 + + + +S ++ V S + + D T +W Sbjct: 488 LVSYKGHSSSVWDVKFSPMGHYFATASHDQTARLW 522 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 37/143 (25%), Positives = 61/143 (42%), Gaps = 18/143 (12%) Query: 329 KGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDV 388 KG+ G SG + + R + ++ + + R+W+ D C + G + V Sbjct: 444 KGSRRLVGHSGAVYGVDFSPDNR--YLISCSEDKTVRLWSL-DTYTC--LVSYKGHSSSV 498 Query: 389 TDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETV 448 D+ +SP G Y S DQT RL W D R A H D+ CVE Sbjct: 499 WDVKFSPMGHYFATASHDQTARL---WSCDHIYPLRIFAG---------HLNDVDCVEFH 546 Query: 449 TDTRFV-SGGDEKILRSFDLPKG 470 ++ ++ +G +K R +D+ +G Sbjct: 547 PNSTYLFTGSSDKTARMWDIARG 569 Score = 38.5 bits (88), Expect = 0.010, Method: Compositional matrix adjust. Identities = 29/126 (23%), Positives = 51/126 (40%), Gaps = 4/126 (3%) Query: 5 ITPEAIFIGANKQTQVSDIHKVKKIVAFGAG-KTIALWDPIEPNNKGVYATLKGHEAEVT 63 I P IF G + H + G+ KT +WD V+ GH + Sbjct: 527 IYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTARMWDIARGECVRVFM---GHSGAIN 583 Query: 64 CVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCAD 123 C+ PD ++ SA ED V +W + ++ ++ S +A S +++ AD Sbjct: 584 CLAVSPDGRWLASAGEDSVVCLWDISTGRRIKAMRGHGRSSIYSLAFSREGTVLVSTGAD 643 Query: 124 GTISIW 129 ++ +W Sbjct: 644 NSVRVW 649 Score = 38.5 bits (88), Expect = 0.011, Method: Compositional matrix adjust. Identities = 35/153 (22%), Positives = 65/153 (42%), Gaps = 15/153 (9%) Query: 531 SLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIF 590 SLL+ P Q + +L GH + +D SPD + + S ++ +R++ Sbjct: 426 SLLKNDPYNQQNNDGVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCS-----EDKTVRLW 480 Query: 591 STENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEK 650 S + + + + HS ++ +KFS G + + D+ LW D+ + LR Sbjct: 481 SLDTYTCLV-SYKGHSSSVWDVKFSPMGHYFATASHDQTARLWSC---DHIYPLRI---- 532 Query: 651 PHTRIIWDADWAPLEFGNVFV-TASRDKTVKVW 682 + D D + ++ T S DKT ++W Sbjct: 533 -FAGHLNDVDCVEFHPNSTYLFTGSSDKTARMW 564 Score = 38.5 bits (88), Expect = 0.013, Method: Compositional matrix adjust. Identities = 25/91 (27%), Positives = 41/91 (45%), Gaps = 5/91 (5%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 V GH I CL +SPD + +ASA +++V+ ++ IK +I Sbjct: 572 VRVFMGHSGAINCLAVSPDGRWLASAG-----EDSVVCLWDISTGRRIKAMRGHGRSSIY 626 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNMEDNT 641 L FS++G L+S D +W+ N+ Sbjct: 627 SLAFSREGTVLVSTGADNSVRVWDVKKNTNS 657 >5GAN-H nrPDB Length = 465 Score = 43.5 bits (101), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 54/230 (23%), Positives = 90/230 (39%), Gaps = 69/230 (30%) Query: 51 VYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHL---------------Q 95 + L GHE ++ V++ P F+ SAS D ++W + + L Q Sbjct: 257 LLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQ 316 Query: 96 C------------------------IQTIQHYSKTIVALSALPS--LISVGCADGTISIW 129 C + T+ +SK I ++ P+ ++ G DG I++W Sbjct: 317 CDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVW 376 Query: 130 RQNIQNDEFG-----LAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTN-VNVFIASFI 183 +I+ + G LAH + + F SK + K L++ G N +NV+ + Sbjct: 377 --DIRKRDEGQLNQILAHRNIVTQVRF-------SKEDGGKKLVSCGYDNLINVYSSDTW 427 Query: 184 LSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW 233 L + L GH D + SL + + L SG DR I+LW Sbjct: 428 LK---------MGSLAGHTDKIISLDI----SNNSHFLVSGGWDRSIKLW 464 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 53/232 (22%), Positives = 84/232 (36%), Gaps = 50/232 (21%) Query: 542 LQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIF---STENWLEI 598 L L P +KL H +I +D PD +C ++ +I+ F + E L + Sbjct: 202 LNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISC----AEDGLIKNFQYSNEEGGLRL 257 Query: 599 KPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALW----------ERNMEDNTFELRFKN 648 L H I+ +K+ GKF+ S D W LW + + F L F+ Sbjct: 258 LGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQC 317 Query: 649 EKP---------------------------HTRIIWDADWAPLEFGNVFVTASRDKTVKV 681 + H++ I+ W+P G T D + V Sbjct: 318 DGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWSP--NGYQVATGGGDGIINV 375 Query: 682 WRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYS 733 W +K D+ L + H VT + +K L+S G +N I +YS Sbjct: 376 WDIRKR--DEGQLNQILAHRNIVTQVRFSKEDGGKK-LVSCGYDN-LINVYS 423 Score = 30.0 bits (66), Expect = 3.6, Method: Compositional matrix adjust. Identities = 16/48 (33%), Positives = 27/48 (56%), Gaps = 1/48 (2%) Query: 586 VIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALW 633 +I ++S++ WL++ +L H+ I L S + FL+S DR LW Sbjct: 418 LINVYSSDTWLKM-GSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLW 464 Score = 29.3 bits (64), Expect = 6.9, Method: Compositional matrix adjust. Identities = 32/143 (22%), Positives = 60/143 (41%), Gaps = 22/143 (15%) Query: 261 FQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCS 320 FQ +E G+ ++GH+ IS +++H S + +A+ D + +W+ Sbjct: 246 FQYSNE-EGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQ-----E 299 Query: 321 LRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLG 380 L L E KG + + G C + G +W + + + Sbjct: 300 LLLQEGHDKGVFSLSFQCDGSLVC------------SGGMDSLSMLWDIRSG---SKVMT 344 Query: 381 ISGATKDVTDIAWSPSGEYLLAT 403 ++G +K + +AWSP+G Y +AT Sbjct: 345 LAGHSKPIYTVAWSPNG-YQVAT 366 >2HES-X nrPDB Length = 330 Score = 43.5 bits (101), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 30/102 (29%), Positives = 53/102 (51%), Gaps = 9/102 (8%) Query: 37 TIALWDPIEPNNK----GVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYS 92 T+++W E ++ + A ++GHE EV V + D ++ + S D V IW+ TD S Sbjct: 81 TVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWE-TDES 139 Query: 93 --HLQCIQTIQHYSKTIVALSALPS--LISVGCADGTISIWR 130 +CI +Q +S+ + + PS L++ D T+ IW+ Sbjct: 140 GEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWK 181 Score = 37.7 bits (86), Expect = 0.019, Method: Compositional matrix adjust. Identities = 47/200 (23%), Positives = 78/200 (39%), Gaps = 28/200 (14%) Query: 57 GHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYS----HLQCIQTIQHYSKTI--VAL 110 H+ + V + P + + + S D V IW + + + + I+ + + VA Sbjct: 56 AHKKAIRSVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAW 115 Query: 111 SALPSLISVGCADGTISIWRQNIQNDEFGL-----AHEFTIKKGFFYPLCLSLSKVEEKK 165 S ++ D ++ IW + +E+ H +K ++P + Sbjct: 116 SNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHP----------SE 165 Query: 166 YLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGS 225 LLA + V I D VA L GHE V S F +T G + LCSGS Sbjct: 166 ALLASSSYDDTVRIWKDYDDD-----WECVAVLNGHEGTVWSSDF--DKTEGVFRLCSGS 218 Query: 226 QDRYIRLWRIRINDLIDDSE 245 D +R+W+ +D D E Sbjct: 219 DDSTVRVWKYMGDDEDDQQE 238 Score = 36.2 bits (82), Expect = 0.059, Method: Compositional matrix adjust. Identities = 39/161 (24%), Positives = 68/161 (42%), Gaps = 33/161 (20%) Query: 167 LLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQ 226 +LA G T+ + + S D + V + H+ ++S+A+R P LL +GS Sbjct: 26 ILATGSTDRKIKLVSVKYDDFTLID---VLDETAHKKAIRSVAWR----PHTSLLAAGSF 78 Query: 227 DRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISS 286 D + +W ++E+S T F++D A+I GH++ + Sbjct: 79 DSTVSIW----------AKEESADRT--------FEMD--------LLAIIEGHENEVKG 112 Query: 287 LQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMS 327 + W L + D S+ +WE DE+ + C L E S Sbjct: 113 VAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHS 153 Score = 33.9 bits (76), Expect = 0.26, Method: Compositional matrix adjust. Identities = 52/235 (22%), Positives = 96/235 (40%), Gaps = 18/235 (7%) Query: 556 GHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFS 615 GH E+ + S D +A+ R +V + + E L HS + + + Sbjct: 105 GHENEVKGVAWSNDGYYLATCSRDKSVW--IWETDESGEEYECISVLQEHSQDVKHVIWH 162 Query: 616 KDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASR 675 L S D +W ++ +D+ + N H +W +D+ E + S Sbjct: 163 PSEALLASSSYDDTVRIW-KDYDDDWECVAVLN--GHEGTVWSSDFDKTEGVFRLCSGSD 219 Query: 676 DKTVKVWRHQKEPADD---YVLEASIK--HTKAVTAISIHDSMIREKILISVGLENGEIY 730 D TV+VW++ + DD +V EA + H + V ++ ++ SVG +G + Sbjct: 220 DSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWG----FNGLIASVGA-DGVLA 274 Query: 731 LYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYSL 785 +Y G++++ + +I ++W L+ NGK L G D +SL Sbjct: 275 VYEEVDGEWKVFAK-RALCHGVYEINVVKW--LELNGKTILATGGDDGIVNFWSL 326 Score = 32.7 bits (73), Expect = 0.71, Method: Compositional matrix adjust. Identities = 76/396 (19%), Positives = 149/396 (37%), Gaps = 85/396 (21%) Query: 92 SHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGL-------AHEF 144 + + I++++ Y + I + +++ G D I + +++ D+F L AH+ Sbjct: 2 ASINLIKSLKLYKEKIWSFDFSQGILATGSTDRKIKL--VSVKYDDFTLIDVLDETAHKK 59 Query: 145 TIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDW 204 I+ + P LLA G + V I + S + ++A +EGHE+ Sbjct: 60 AIRSVAWRP----------HTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENE 109 Query: 205 VKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQID 264 VK +A+ + Y L + S+D+ + +W D+S E+ + +++L Sbjct: 110 VKGVAWSND----GYYLATCSRDKSVWIWET------DESGEEYECISVLQE-------- 151 Query: 265 DELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLG 324 H + + WH S L +++ D ++ +W+ + W C Sbjct: 152 ---------------HSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDD--WEC----- 189 Query: 325 EMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGA 384 + G G WS + E + + + R+W + DQ+ + A Sbjct: 190 ------VAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEA 243 Query: 385 T------KDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIH 438 + V ++AW +G + + D ++ + G + A R H Sbjct: 244 ILPDVHKRQVYNVAWGFNG-LIASVGADGVLAVYE----EVDGEWKVFA-----KRALCH 293 Query: 439 GYDMICV----ETVTDTRFVSGGDEKILRSFDLPKG 470 G I V E T +GGD+ I+ + L K Sbjct: 294 GVYEINVVKWLELNGKTILATGGDDGIVNFWSLEKA 329 >5UZ7-B nrPDB Length = 351 Score = 42.7 bits (99), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 66/285 (23%), Positives = 110/285 (38%), Gaps = 39/285 (13%) Query: 42 DPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQ 101 DP+ TL+GH A++ + + DS +VSAS+D + IW D + I Sbjct: 49 DPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIW---DSYTTNKVHAIP 105 Query: 102 HYSKTIVALSALPSLISVGCA--DGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLS 159 S ++ + PS V C D SI+ + ++ E G+ LS Sbjct: 106 LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGY-----LSCC 160 Query: 160 K-VEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGD 218 + +++ + + + G T ++ IE + GH V SL+ P Sbjct: 161 RFLDDNQIVTSSGDTTCALW---------DIETGQQTTTFTGHTGDVMSLSL----APDT 207 Query: 219 YLLCSGSQDRYIRLWRIR---INDLIDDSEEDSKKLTLLSN-KQYKFQIDD------ELR 268 L SG+ D +LW +R E D + N + DD +LR Sbjct: 208 RLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLR 267 Query: 269 VGINFEALIMGHDD---WISSLQWHESRLQLLAATADTSLMVWEP 310 + E + HD+ I+S+ + +S LLA D + VW+ Sbjct: 268 A--DQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDA 310 Score = 32.7 bits (73), Expect = 0.56, Method: Compositional matrix adjust. Identities = 15/48 (31%), Positives = 25/48 (52%), Gaps = 3/48 (6%) Query: 40 LWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWK 87 +WD ++ + GV L GH+ V+C+ D + + S D +KIW Sbjct: 307 VWDALKADRAGV---LAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 351 Score = 29.6 bits (65), Expect = 5.1, Method: Compositional matrix adjust. Identities = 26/109 (23%), Positives = 47/109 (43%), Gaps = 7/109 (6%) Query: 236 RINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQ 295 ++ + I D+ + TL Q ID R+ + + GH I ++ W Sbjct: 24 QLKNQIRDARKACADATL---SQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRL 80 Query: 296 LLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSC 344 L++A+ D L++W+ T+ + LR SS + A SG + +C Sbjct: 81 LVSASQDGKLIIWDSYTTNKVHAIPLR----SSWVMTCAYAPSGNYVAC 125 Score = 28.9 bits (63), Expect = 9.2, Method: Compositional matrix adjust. Identities = 25/136 (18%), Positives = 54/136 (39%), Gaps = 21/136 (15%) Query: 277 IMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATG 336 + GH ++S ++ + Q++ ++ DT+ +W+ + + G++ S + T Sbjct: 150 LAGHTGYLSCCRFLDDN-QIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDT- 207 Query: 337 SSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPS 396 F++ S ++W ++ + R +G D+ I + P+ Sbjct: 208 ----------------RLFVSGACDASAKLWDVREGMC---RQTFTGHESDINAICFFPN 248 Query: 397 GEYLLATSLDQTTRLF 412 G S D T RLF Sbjct: 249 GNAFATGSDDATCRLF 264 >4BZK-B nrPDB Length = 297 Score = 42.4 bits (98), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 61/247 (24%), Positives = 105/247 (42%), Gaps = 29/247 (11%) Query: 27 KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPD--SDFMVSASEDHHVK 84 K++ + KTI +++ +E + TL GHE V V + + S S D V Sbjct: 22 KRLATCSSDKTIKIFE-VEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 Query: 85 IWKFTDYSHLQCIQTIQHYSKTIVALSALP----SLISVGCADGTISI--WRQNIQNDEF 138 IWK + Q H S ++ ++ P L+ V +DG +S+ +++N Sbjct: 81 IWKEENGRWSQIAVHAVH-SASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPI 139 Query: 139 GL-AHEFTIKKGFFYPLCLSL-----SKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKC 192 + AH + + P + E +K++ GG + V I + +S + Sbjct: 140 IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFV--TGGADNLVKIWKY---NSDAQTY 194 Query: 193 RVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLT 252 + + LEGH DWV+ +A+ Y L S SQDR +W D+E+ K T Sbjct: 195 VLESTLEGHSDWVRDVAWSPTVLLRSY-LASVSQDRTCIIW-------TQDNEQGPWKKT 246 Query: 253 LLSNKQY 259 LL +++ Sbjct: 247 LLKEEKF 253 Score = 34.3 bits (77), Expect = 0.23, Method: Compositional matrix adjust. Identities = 18/68 (26%), Positives = 32/68 (47%), Gaps = 2/68 (2%) Query: 620 FLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTV 679 +L SV +DR +W ++ E ++ E+ ++W A W+ GNV + D V Sbjct: 221 YLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSL--SGNVLALSGGDNKV 278 Query: 680 KVWRHQKE 687 +W+ E Sbjct: 279 TLWKENLE 286 Score = 32.3 bits (72), Expect = 0.72, Method: Compositional matrix adjust. Identities = 18/68 (26%), Positives = 32/68 (47%), Gaps = 6/68 (8%) Query: 257 KQYKFQIDDELRVGINFEALIMGHDDWISSLQWHES---RLQLLAATADTSLMVWEPDET 313 K +K+ D + V E+ + GH DW+ + W + R L + + D + ++W D Sbjct: 183 KIWKYNSDAQTYV---LESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNE 239 Query: 314 SGIWVCSL 321 G W +L Sbjct: 240 QGPWKKTL 247 Score = 30.8 bits (68), Expect = 2.7, Method: Compositional matrix adjust. Identities = 19/68 (27%), Positives = 32/68 (47%), Gaps = 3/68 (4%) Query: 618 GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDK 677 GK L + D+ ++E +E T +L H +W DWA +FG + + S D Sbjct: 21 GKRLATCSSDKTIKIFE--VEGETHKL-IDTLTGHEGPVWRVDWAHPKFGTILASCSYDG 77 Query: 678 TVKVWRHQ 685 V +W+ + Sbjct: 78 KVLIWKEE 85 Score = 30.0 bits (66), Expect = 3.8, Method: Compositional matrix adjust. Identities = 43/189 (22%), Positives = 78/189 (41%), Gaps = 26/189 (13%) Query: 551 VEKLYGHGFEITCLDIS-PDQKLIASACRSNNVQNAVIRIFSTEN--WLEIKPALPFHSL 607 ++ L GH + +D + P I ++C + + I+ EN W +I HS Sbjct: 46 IDTLTGHEGPVWRVDWAHPKFGTILASCS----YDGKVLIWKEENGRWSQI-AVHAVHSA 100 Query: 608 TITRLKFSKD--GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLE 665 ++ ++++ G LL D K ++ E T + H + A WAP Sbjct: 101 SVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIID---AHAIGVNSASWAPAT 157 Query: 666 F-----------GNVFVTASRDKTVKVWRHQKEPADDYVLEASIK-HTKAVTAISIHDSM 713 FVT D VK+W++ + A YVLE++++ H+ V ++ ++ Sbjct: 158 IEEDGEHNGTKESRKFVTGGADNLVKIWKYNSD-AQTYVLESTLEGHSDWVRDVAWSPTV 216 Query: 714 IREKILISV 722 + L SV Sbjct: 217 LLRSYLASV 225 Score = 30.0 bits (66), Expect = 3.9, Method: Compositional matrix adjust. Identities = 27/98 (27%), Positives = 43/98 (43%), Gaps = 6/98 (6%) Query: 587 IRIFSTENWL-EIKPALPFHSLTITRLKFS--KDGKFLLSVCRDRKWALWERNMEDNTFE 643 I+IF E ++ L H + R+ ++ K G L S D K +W+ E+N Sbjct: 33 IKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK---EENGRW 89 Query: 644 LRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKV 681 + H+ + WAP E+G + + AS D V V Sbjct: 90 SQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 127 >5WYK-BB nrPDB Length = 943 Score = 42.4 bits (98), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 28/112 (25%), Positives = 55/112 (49%), Gaps = 7/112 (6%) Query: 28 KIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWK 87 ++++ I +WD + G+Y L+ H+ +T + D+++S S+D +K+W Sbjct: 135 RLISGSKDSNIIVWDLV--GEVGLYK-LRSHKDSITGF-WCQGEDWLISTSKDGMIKLW- 189 Query: 88 FTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFG 139 D QCI+T ++ L+ L+ D + IW+ +I+ND+ G Sbjct: 190 --DLKTHQCIETHIAHTGECWGLAVKDDLLITTGTDSQVKIWKLDIENDKMG 239 Score = 38.5 bits (88), Expect = 0.011, Method: Compositional matrix adjust. Identities = 28/107 (26%), Positives = 46/107 (42%), Gaps = 8/107 (7%) Query: 27 KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIW 86 K I+ A K I +W + + +L H+ + V+F+P S S S+D VK W Sbjct: 586 KMIITSSADKNIKIWGL---DFGDCHKSLFAHQDSIMNVKFLPQSHNFFSCSKDAVVKYW 642 Query: 87 KFTDYSHLQCIQTIQHYSKTIVALSALP--SLISVGCADGTISIWRQ 131 D +CIQ + + + AL+ + D +I IW + Sbjct: 643 ---DGEKFECIQKLYAHQSEVWALAVATDGGFVVSSSHDHSIRIWEE 686 Score = 36.6 bits (83), Expect = 0.046, Method: Compositional matrix adjust. Identities = 29/127 (22%), Positives = 56/127 (44%), Gaps = 13/127 (10%) Query: 560 EITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGK 619 +I C+ +SPD + +A + N V ++F ++ ++ +L H L + + S D K Sbjct: 533 DILCVRVSPDDRYLAISLLDNTV-----KVFFLDS-MKFYLSLYGHKLPVLSIDISFDSK 586 Query: 620 FLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTV 679 +++ D+ +W + D K+ H I + + P F + S+D V Sbjct: 587 MIITSSADKNIKIWGLDFGDC-----HKSLFAHQDSIMNVKFLPQSHN--FFSCSKDAVV 639 Query: 680 KVWRHQK 686 K W +K Sbjct: 640 KYWDGEK 646 Score = 35.4 bits (80), Expect = 0.095, Method: Compositional matrix adjust. Identities = 40/140 (28%), Positives = 59/140 (42%), Gaps = 25/140 (17%) Query: 553 KLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRL 612 +L G ++ +DIS D KL+A+A N ++I++ + I+ ++LT Sbjct: 386 ELQGQRTDVRSIDISDDNKLLATA------SNGSLKIWNIKTHKCIRTFECGYALTC--- 436 Query: 613 KFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKN-----EKPHTRIIWDADWAPLEFG 667 KF G ++ L RN E F+L + E H IW D G Sbjct: 437 KFLPGGLLVI---------LGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTS--DG 485 Query: 668 NVFVTASRDKTVKVWRHQKE 687 VT S DKTVK W + E Sbjct: 486 KRLVTGSADKTVKFWDFKVE 505 Score = 33.9 bits (76), Expect = 0.26, Method: Compositional matrix adjust. Identities = 14/36 (38%), Positives = 23/36 (63%) Query: 55 LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTD 90 L H++EV + D F+VS+S DH ++IW+ T+ Sbjct: 653 LYAHQSEVWALAVATDGGFVVSSSHDHSIRIWEETE 688 Score = 33.9 bits (76), Expect = 0.30, Method: Compositional matrix adjust. Identities = 31/134 (23%), Positives = 56/134 (41%), Gaps = 13/134 (9%) Query: 554 LYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLK 613 LYGH + +DIS D K+I ++ N I+I+ + + + +L H +I +K Sbjct: 569 LYGHKLPVLSIDISFDSKMIITSSADKN-----IKIWGLD-FGDCHKSLFAHQDSIMNVK 622 Query: 614 FSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTA 673 F S +D W + FE + H +W A G V++ Sbjct: 623 FLPQSHNFFSCSKDAVVKYW----DGEKFEC-IQKLYAHQSEVWAL--AVATDGGFVVSS 675 Query: 674 SRDKTVKVWRHQKE 687 S D ++++W ++ Sbjct: 676 SHDHSIRIWEETED 689 Score = 32.3 bits (72), Expect = 0.91, Method: Compositional matrix adjust. Identities = 17/63 (26%), Positives = 34/63 (53%), Gaps = 3/63 (4%) Query: 52 YATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALS 111 Y +L GH+ V + DS ++++S D ++KIW D+ C +++ + +I+ + Sbjct: 566 YLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGL-DFG--DCHKSLFAHQDSIMNVK 622 Query: 112 ALP 114 LP Sbjct: 623 FLP 625 Score = 31.6 bits (70), Expect = 1.6, Method: Compositional matrix adjust. Identities = 26/113 (23%), Positives = 45/113 (39%), Gaps = 18/113 (15%) Query: 605 HSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPL 664 H IT L+F G L+S +D +W+ E ++LR + DW Sbjct: 120 HKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGEVGLYKLRSHKDSITGFWCQGEDW--- 176 Query: 665 EFGNVFVTASRDKTVKVW---RHQKEPADDYVLEASIKHTKAVTAISIHDSMI 714 ++ S+D +K+W HQ +E I HT +++ D ++ Sbjct: 177 -----LISTSKDGMIKLWDLKTHQ-------CIETHIAHTGECWGLAVKDDLL 217 >3JRP-A nrPDB Length = 379 Score = 42.4 bits (98), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 61/247 (24%), Positives = 105/247 (42%), Gaps = 29/247 (11%) Query: 27 KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPD--SDFMVSASEDHHVK 84 K++ + KTI +++ +E + TL GHE V V + + S S D V Sbjct: 24 KRLATCSSDKTIKIFE-VEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 82 Query: 85 IWKFTDYSHLQCIQTIQHYSKTIVALSALP----SLISVGCADGTISI--WRQNIQNDEF 138 IWK + Q H S ++ ++ P L+ V +DG +S+ +++N Sbjct: 83 IWKEENGRWSQIAVHAVH-SASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPI 141 Query: 139 GL-AHEFTIKKGFFYPLCLSL-----SKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKC 192 + AH + + P + E +K++ GG + V I + +S + Sbjct: 142 IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFV--TGGADNLVKIWKY---NSDAQTY 196 Query: 193 RVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLT 252 + + LEGH DWV+ +A+ Y L S SQDR +W D+E+ K T Sbjct: 197 VLESTLEGHSDWVRDVAWSPTVLLRSY-LASVSQDRTCIIW-------TQDNEQGPWKKT 248 Query: 253 LLSNKQY 259 LL +++ Sbjct: 249 LLKEEKF 255 Score = 34.7 bits (78), Expect = 0.17, Method: Compositional matrix adjust. Identities = 18/68 (26%), Positives = 32/68 (47%), Gaps = 2/68 (2%) Query: 620 FLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTV 679 +L SV +DR +W ++ E ++ E+ ++W A W+ GNV + D V Sbjct: 223 YLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSL--SGNVLALSGGDNKV 280 Query: 680 KVWRHQKE 687 +W+ E Sbjct: 281 TLWKENLE 288 Score = 33.1 bits (74), Expect = 0.53, Method: Compositional matrix adjust. Identities = 18/68 (26%), Positives = 32/68 (47%), Gaps = 6/68 (8%) Query: 257 KQYKFQIDDELRVGINFEALIMGHDDWISSLQWHES---RLQLLAATADTSLMVWEPDET 313 K +K+ D + V E+ + GH DW+ + W + R L + + D + ++W D Sbjct: 185 KIWKYNSDAQTYV---LESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNE 241 Query: 314 SGIWVCSL 321 G W +L Sbjct: 242 QGPWKKTL 249 Score = 31.6 bits (70), Expect = 1.6, Method: Compositional matrix adjust. Identities = 19/68 (27%), Positives = 32/68 (47%), Gaps = 3/68 (4%) Query: 618 GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDK 677 GK L + D+ ++E +E T +L H +W DWA +FG + + S D Sbjct: 23 GKRLATCSSDKTIKIFE--VEGETHKL-IDTLTGHEGPVWRVDWAHPKFGTILASCSYDG 79 Query: 678 TVKVWRHQ 685 V +W+ + Sbjct: 80 KVLIWKEE 87 Score = 30.0 bits (66), Expect = 3.9, Method: Compositional matrix adjust. Identities = 27/101 (26%), Positives = 44/101 (43%), Gaps = 6/101 (5%) Query: 584 NAVIRIFSTENWL-EIKPALPFHSLTITRLKFS--KDGKFLLSVCRDRKWALWERNMEDN 640 + I+IF E ++ L H + R+ ++ K G L S D K +W+ E+N Sbjct: 32 DKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK---EEN 88 Query: 641 TFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKV 681 + H+ + WAP E+G + + AS D V V Sbjct: 89 GRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 129 Score = 30.0 bits (66), Expect = 4.2, Method: Compositional matrix adjust. Identities = 43/189 (22%), Positives = 78/189 (41%), Gaps = 26/189 (13%) Query: 551 VEKLYGHGFEITCLDIS-PDQKLIASACRSNNVQNAVIRIFSTEN--WLEIKPALPFHSL 607 ++ L GH + +D + P I ++C + + I+ EN W +I HS Sbjct: 48 IDTLTGHEGPVWRVDWAHPKFGTILASCS----YDGKVLIWKEENGRWSQI-AVHAVHSA 102 Query: 608 TITRLKFSKD--GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLE 665 ++ ++++ G LL D K ++ E T + H + A WAP Sbjct: 103 SVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIID---AHAIGVNSASWAPAT 159 Query: 666 F-----------GNVFVTASRDKTVKVWRHQKEPADDYVLEASIK-HTKAVTAISIHDSM 713 FVT D VK+W++ + A YVLE++++ H+ V ++ ++ Sbjct: 160 IEEDGEHNGTKESRKFVTGGADNLVKIWKYNSD-AQTYVLESTLEGHSDWVRDVAWSPTV 218 Query: 714 IREKILISV 722 + L SV Sbjct: 219 LLRSYLASV 227 >3JAP-g nrPDB Length = 326 Score = 42.0 bits (97), Expect = 0.001, Method: Compositional matrix adjust. Identities = 57/202 (28%), Positives = 84/202 (41%), Gaps = 31/202 (15%) Query: 554 LYGHGFEITCLDISPDQ-KLIASACRSNNVQNAVIRIFSTENWLEIKPALPF-----HSL 607 L GH +T L S Q L+ S R +I TEN E + +P HS Sbjct: 14 LEGHNGWVTSLSTSAAQPNLLVSGSR----DKTLISWRLTEN--EQQFGVPVRSYKGHSH 67 Query: 608 TITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHT-RIIWDADWAPLEF 666 + + S DG + +S D+ LW N+ E RF + DA+ + + Sbjct: 68 IVQDVVVSADGNYAVSASWDKTLRLW--NLATGNSEARFVGHTGDVLSVAIDANSSKI-- 123 Query: 667 GNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLEN 726 ++ASRDKT++VW + A YVL + HT VT + + K L +++ Sbjct: 124 ----ISASRDKTIRVWNTVGDCA--YVL---LGHTDWVTKV-----RVAPKNLEDGEVDD 169 Query: 727 GEIYLYSYTLGKFELITQLNED 748 G I S + K LNED Sbjct: 170 GRITFVSAGMDKIVRSWSLNED 191 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 42/184 (22%), Positives = 77/184 (41%), Gaps = 12/184 (6%) Query: 54 TLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTI-VALSA 112 + KGH V V D ++ VSAS D +++W + + + H + VA+ A Sbjct: 61 SYKGHSHIVQDVVVSADGNYAVSASWDKTLRLWNLATGN--SEARFVGHTGDVLSVAIDA 118 Query: 113 LPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGG 172 S I D TI +W L H + K P L +V++ + G Sbjct: 119 NSSKIISASRDKTIRVWNTVGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAG 178 Query: 173 TNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRL 232 ++ + S+ L++ + R+ A+ GH +++ + Q +P L S +D I + Sbjct: 179 --MDKIVRSWSLNE---DSYRIEADFIGHNNYINVV----QPSPDGSLAASAGKDGQIYV 229 Query: 233 WRIR 236 W ++ Sbjct: 230 WNLK 233 Score = 33.1 bits (74), Expect = 0.54, Method: Compositional matrix adjust. Identities = 33/126 (26%), Positives = 56/126 (44%), Gaps = 17/126 (13%) Query: 198 LEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKK------- 250 LEGH WV SL+ + LL SGS+D+ + WR+ N+ S K Sbjct: 14 LEGHNGWVTSLSTSAAQPN---LLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQ 70 Query: 251 -LTLLSNKQYKFQI--DDELRV----GINFEALIMGHDDWISSLQWHESRLQLLAATADT 303 + + ++ Y D LR+ N EA +GH + S+ + ++++A+ D Sbjct: 71 DVVVSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIISASRDK 130 Query: 304 SLMVWE 309 ++ VW Sbjct: 131 TIRVWN 136 Score = 30.8 bits (68), Expect = 2.3, Method: Compositional matrix adjust. Identities = 16/52 (30%), Positives = 27/52 (51%), Gaps = 3/52 (5%) Query: 36 KTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWK 87 KT+ LW+ N++ A GH +V V +S ++SAS D +++W Sbjct: 88 KTLRLWNLATGNSE---ARFVGHTGDVLSVAIDANSSKIISASRDKTIRVWN 136 >5K1B-B nrPDB Length = 677 Score = 42.0 bits (97), Expect = 0.001, Method: Compositional matrix adjust. Identities = 49/212 (23%), Positives = 82/212 (38%), Gaps = 16/212 (7%) Query: 26 VKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKI 85 + ++ G I +W + A+++ H V + + ++SAS D VK+ Sbjct: 42 LNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKV 101 Query: 86 WKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFT 145 W + ++T + Y K + A + L++ D I +W N + T Sbjct: 102 WNAHKGFCMSTLRTHKDYVKAL-AYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVT 160 Query: 146 IKKGFFYPLCLSLSKVEEKKYLLAIG--GTNVNVFIASFILSDSGIEKCRVVAELEGHED 203 SLS ++ Y LA+ GT + +L C + +L+GH D Sbjct: 161 TS---------SLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTD 211 Query: 204 WVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI 235 VK+L T SGS D IRLW + Sbjct: 212 NVKALLLNRDGTQ----CLSGSSDGTIRLWSL 239 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 40/180 (22%), Positives = 80/180 (44%), Gaps = 19/180 (10%) Query: 62 VTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYS---KTIVALSALPSLIS 118 V ++ P + + +A D ++IW + I +++H++ IV +LIS Sbjct: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLIS 92 Query: 119 VGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVF 178 +D T+ +W N G T++ Y L+ +K +E L+A G + +F Sbjct: 93 AS-SDTTVKVW-----NAHKGFCMS-TLRTHKDYVKALAYAKDKE---LVASAGLDRQIF 142 Query: 179 I--ASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIR 236 + + + + + + L G++D + SLA T ++ SGS ++ +R+W R Sbjct: 143 LWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGT----IIVSGSTEKVLRVWDPR 198 Score = 35.0 bits (79), Expect = 0.11, Method: Compositional matrix adjust. Identities = 72/375 (19%), Positives = 134/375 (35%), Gaps = 88/375 (23%) Query: 195 VAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLL 254 +A +E H DWV + L S S D +++W Sbjct: 68 IASMEHHTDWVNDIVL----CCNGKTLISASSDTTVKVW--------------------- 102 Query: 255 SNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETS 314 N F + + + H D++ +L + + + + +A D + +W+ + + Sbjct: 103 -NAHKGFCM-----------STLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLT 150 Query: 315 GIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGS-WRMWATKDNI 373 + +S T + SG S ++ + +G T R+W D Sbjct: 151 AL---------TASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVW---DPR 198 Query: 374 ICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFS 433 C + + + G T +V + + G L+ S D T RL+ + G++R IAT+ Sbjct: 199 TCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLW------SLGQQRCIATY---- 248 Query: 434 RPQIHGYDMICVETVTDTRFVSGGDEKI----LRSFDLPKGVAGMLQKFVGIQFEEKSEM 489 R G + V + G D KI LR+ D+ + + ++ + ++ Sbjct: 249 RVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDRSADP 308 Query: 490 PDSATVPVL----------GLSNKAGEDDANEDDEEEEGGNKETPDITDP-------LSL 532 P + V G+ N D + D N TP T P S+ Sbjct: 309 PPAIWVATTKSTVNKWTLKGIHNFRASGDYDND-----CTNPITPLCTQPDQVIKGGASI 363 Query: 533 LECPPMEDQLQRHLL 547 ++C + D +RH+L Sbjct: 364 IQCHILND--KRHIL 376 >5K19-A nrPDB Length = 569 Score = 42.0 bits (97), Expect = 0.001, Method: Compositional matrix adjust. Identities = 62/242 (25%), Positives = 107/242 (44%), Gaps = 40/242 (16%) Query: 26 VKKIVAFGAGKTIALWDPIEPNNKGVYATLKG-HEAEVTCVRFVPDSD--FMVSASED-- 80 V +V F AG+ + L DPI+ ++ + ++ VTCV++VP S+ F+V+ S Sbjct: 116 VSLLVGFSAGQ-VQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNM 174 Query: 81 --HHVKIWKFTDYSHLQCIQTIQHYS-KTIVALSALPSLISVGCADGTISIWRQN----- 132 ++V+ T H Q ++ + ++ T + S L+ +G ++ + + Sbjct: 175 YLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKF 234 Query: 133 ---IQNDEFGLAHEF-------TIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASF 182 + D F F T+K F LC+ S + KY++ GG + V + SF Sbjct: 235 LACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWS--PDGKYIVT-GGEDDLVTVWSF 291 Query: 183 ILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETP---GDYLLCSGSQDRY---IRLWRIR 236 + CRV+A GH+ WV +AF T GD + SGS + + + R R Sbjct: 292 V-------DCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDR 344 Query: 237 IN 238 N Sbjct: 345 AN 346 >6J6H-n nrPDB Length = 455 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 41/193 (21%), Positives = 74/193 (38%), Gaps = 22/193 (11%) Query: 49 KGVYATLKGHEAEVTCVRFVPDSDFMV-SASEDHHVKIWKFTDYSHLQCIQTIQHYSKTI 107 K V GH T ++F+P + ++ S DH +KIW F Y +C++ Q ++K I Sbjct: 152 KKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF--YHDYECLRDFQGHNKPI 209 Query: 108 VALSALPSLISV--GCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKK 165 AL S D ++ IW + L T P + + Sbjct: 210 KALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNST-------PADVESRPTNPHE 262 Query: 166 YLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGS 225 +++ + + + D E +V + H + +L + P S S Sbjct: 263 FIVGLSNSKI------LHYDDRVSENQGLVQTYDHHLSSILALKY----FPDGSKFISSS 312 Query: 226 QDRYIRLWRIRIN 238 +D+ +R+W +IN Sbjct: 313 EDKTVRIWENQIN 325 Score = 34.3 bits (77), Expect = 0.19, Method: Compositional matrix adjust. Identities = 17/59 (28%), Positives = 30/59 (50%), Gaps = 1/59 (1%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWK 87 IV K + D + N+G+ T H + + +++ PD +S+SED V+IW+ Sbjct: 264 IVGLSNSKILHYDDRVS-ENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321 Score = 32.7 bits (73), Expect = 0.69, Method: Compositional matrix adjust. Identities = 18/58 (31%), Positives = 28/58 (48%), Gaps = 2/58 (3%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIW 86 I++ G TI +WD ++ +GH + +RF D +S+S D VKIW Sbjct: 178 ILSGGNDHTIKIWDFY--HDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIW 233 Score = 29.6 bits (65), Expect = 5.6, Method: Compositional matrix adjust. Identities = 28/124 (22%), Positives = 45/124 (36%), Gaps = 25/124 (20%) Query: 564 LDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITR----------LK 613 L++ P Q + N RI+S +KP H I + L Sbjct: 342 LNVHPSQNYFCAQSMDN-------RIYS----FSLKPKYKRHPKKIFKGHSSAGYGISLA 390 Query: 614 FSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTA 673 FS DG+++ S + W+ N ++ KP T++ DW P E V + Sbjct: 391 FSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQV----DWHPQETSKVICSG 446 Query: 674 SRDK 677 + K Sbjct: 447 AAGK 450 >5WYJ-BC nrPDB Length = 817 Score = 40.4 bits (93), Expect = 0.003, Method: Compositional matrix adjust. Identities = 55/236 (23%), Positives = 101/236 (42%), Gaps = 29/236 (12%) Query: 5 ITPEAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTC 64 I+ I+ G+ + V+ + + KI+A I + D + K ++ E E+T Sbjct: 10 ISLNPIYAGS---SAVATVSENGKILATPVLDEINIIDLTPGSRKILHKISNEDEQEITA 66 Query: 65 VRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKT----IVALSALPSLISVG 120 ++ PD ++ S+ +KI+ HL+ + ++ + I+ + +L++VG Sbjct: 67 LKLTPDGQYLTYVSQAQLLKIF------HLKTGKVVRSMKISSPSYILDADSTSTLLAVG 120 Query: 121 CADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIA 180 DG+I + +I+N + H F G L ++ K +LLA G TN V + Sbjct: 121 GTDGSIIV--VDIENGY--ITHSFKGHGGTISSLKF-YGQLNSKIWLLASGDTNGMVKVW 175 Query: 181 SFILSDSGIEKCRVVAELEGHEDWVKSL---AFRHQETPGDYLLCSGSQDRYIRLW 233 + K + + L+ H V+ L + P LL SG +D I LW Sbjct: 176 DLV-------KRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLL-SGGRDDIINLW 223 Score = 40.4 bits (93), Expect = 0.003, Method: Compositional matrix adjust. Identities = 33/120 (27%), Positives = 54/120 (45%), Gaps = 16/120 (13%) Query: 605 HSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPL 664 H I L S + + D+ +W N+E+ E N H R +WD + Sbjct: 490 HEKDINALSVSPNDSIFATASYDKTCKIW--NLENGELEATLAN---HKRGLWDVSFC-- 542 Query: 665 EFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIK-HTKAVTAISIHDSMIREKILISVG 723 ++ + T+S DKTVK+W D + + +++ HT AV S + ++K LIS G Sbjct: 543 QYDKLLATSSGDKTVKIWS-----LDTFSVMKTLEGHTNAVQRCSFIN---KQKQLISCG 594 Score = 36.2 bits (82), Expect = 0.050, Method: Compositional matrix adjust. Identities = 27/94 (28%), Positives = 44/94 (46%), Gaps = 4/94 (4%) Query: 36 KTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQ 95 KT +W+ N + ATL H+ + V F + ++S D VKIW +S ++ Sbjct: 513 KTCKIWNL---ENGELEATLANHKRGLWDVSFCQYDKLLATSSGDKTVKIWSLDTFSVMK 569 Query: 96 CIQTIQHYSKTIVALSALPSLISVGCADGTISIW 129 ++ + + ++ LIS G ADG I IW Sbjct: 570 TLEGHTNAVQRCSFINKQKQLISCG-ADGLIKIW 602 Score = 35.8 bits (81), Expect = 0.081, Method: Compositional matrix adjust. Identities = 30/105 (28%), Positives = 45/105 (42%), Gaps = 23/105 (21%) Query: 167 LLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQ 226 LLA+GGT+ S I+ D IE + +GH + SL F Q +LL SG Sbjct: 116 LLAVGGTD-----GSIIVVD--IENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDT 168 Query: 227 DRYIRLW----------------RIRINDLIDDSEEDSKKLTLLS 255 + +++W +R D+I+ + D L LLS Sbjct: 169 NGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLS 213 Score = 35.0 bits (79), Expect = 0.11, Method: Compositional matrix adjust. Identities = 22/73 (30%), Positives = 36/73 (49%), Gaps = 3/73 (4%) Query: 15 NKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFM 74 N + S I+K K++++ GA I +WD ++ TL GH + + + D D + Sbjct: 576 NAVQRCSFINKQKQLISCGADGLIKIWDC---SSGECLKTLDGHNNRLWALSTMNDGDMI 632 Query: 75 VSASEDHHVKIWK 87 VSA D + WK Sbjct: 633 VSADADGVFQFWK 645 Score = 31.6 bits (70), Expect = 1.3, Method: Compositional matrix adjust. Identities = 37/142 (26%), Positives = 56/142 (39%), Gaps = 10/142 (7%) Query: 550 EVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTI 609 +VE GH + LD + D IA+A + N V R +I HS + Sbjct: 380 DVEIYEGHEDLLNSLDATEDGLWIATASKDNTA--IVWRYNENSCKFDIYAKYIGHSAAV 437 Query: 610 TRLKF----SKD-GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPL 664 T + SK +FLL+ D W + +++ +TR + D L Sbjct: 438 TAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINAL 497 Query: 665 EFG---NVFVTASRDKTVKVWR 683 ++F TAS DKT K+W Sbjct: 498 SVSPNDSIFATASYDKTCKIWN 519 Score = 30.8 bits (68), Expect = 2.4, Method: Compositional matrix adjust. Identities = 14/40 (35%), Positives = 21/40 (52%) Query: 670 FVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISI 709 TAS+D T VWR+ + + I H+ AVTA+ + Sbjct: 403 IATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGL 442 Score = 29.6 bits (65), Expect = 6.0, Method: Compositional matrix adjust. Identities = 18/78 (23%), Positives = 34/78 (43%), Gaps = 5/78 (6%) Query: 54 TLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTI--VALS 111 T HE ++ + P+ +AS D KIW + L+ T+ ++ + + V+ Sbjct: 486 TRHAHEKDINALSVSPNDSIFATASYDKTCKIWNLEN-GELEA--TLANHKRGLWDVSFC 542 Query: 112 ALPSLISVGCADGTISIW 129 L++ D T+ IW Sbjct: 543 QYDKLLATSSGDKTVKIW 560 >5OQL-d nrPDB Length = 446 Score = 40.4 bits (93), Expect = 0.003, Method: Compositional matrix adjust. Identities = 23/78 (29%), Positives = 37/78 (47%), Gaps = 2/78 (2%) Query: 56 KGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS 115 KGH A V V F P + +VS S D +++W+ D H + + + + + + S Sbjct: 280 KGHVAAVMDVEFSPTGEELVSGSYDRTIRLWR-RDAGHSRDVYHTKRMQRVFRTMWTMDS 338 Query: 116 -LISVGCADGTISIWRQN 132 I G DG + +WR N Sbjct: 339 KYILTGSDDGNVRLWRAN 356 Score = 34.3 bits (77), Expect = 0.23, Method: Compositional matrix adjust. Identities = 52/205 (25%), Positives = 77/205 (37%), Gaps = 33/205 (16%) Query: 38 IALWDP-IEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQC 96 I LWDP P+N AT + T + F ++ ++S ++IW D H Sbjct: 132 IKLWDPYASPSNTTPIATWQ-EGGPYTSLSFHRSANTFAASSGQGCIRIW---DLEHSTA 187 Query: 97 IQTIQ--HYSKTIVAL---SALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFF 151 Q IQ + TI + S+I D +I + F L + K Sbjct: 188 GQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIIL---------FDLRTNMPVIKTVL 238 Query: 152 YPLC--LSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLA 209 + C + + +E +A N+ +F A I+K GH V + Sbjct: 239 HFACNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQK--------GHVAAVMDVE 290 Query: 210 FRHQETPGDYLLCSGSQDRYIRLWR 234 F +P L SGS DR IRLWR Sbjct: 291 F----SPTGEELVSGSYDRTIRLWR 311 Score = 32.0 bits (71), Expect = 0.95, Method: Compositional matrix adjust. Identities = 21/52 (40%), Positives = 30/52 (57%), Gaps = 5/52 (9%) Query: 376 DQRLGIS-GATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREI 426 D+ L I G V D+ +SP+GE L++ S D+T RL W DA G R++ Sbjct: 273 DKALNIQKGHVAAVMDVEFSPTGEELVSGSYDRTIRL---WRRDA-GHSRDV 320 Score = 31.6 bits (70), Expect = 1.6, Method: Compositional matrix adjust. Identities = 28/128 (21%), Positives = 51/128 (39%), Gaps = 12/128 (9%) Query: 587 IRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRF 646 I IF N+ + H + ++FS G+ L+S DR LW R+ + Sbjct: 264 IYIFDARNFDKALNIQKGHVAAVMDVEFSPTGEELVSGSYDRTIRLWRRDAGHSRDVYHT 323 Query: 647 KNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTA 706 K + R +W D +T S D V++WR + +K T+ A Sbjct: 324 KRMQRVFRTMWTMD------SKYILTGSDDGNVRLWRANASE------RSGVKATRQRQA 371 Query: 707 ISIHDSMI 714 + +++++ Sbjct: 372 LEYNNALL 379 >5G04-R nrPDB Length = 499 Score = 40.4 bits (93), Expect = 0.003, Method: Compositional matrix adjust. Identities = 47/188 (25%), Positives = 73/188 (38%), Gaps = 25/188 (13%) Query: 53 ATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTD-YSHLQCIQTIQHYSKTIVALS 111 ATL GH EV +R+ PD + S D+ V +W +QT + + A++ Sbjct: 303 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 362 Query: 112 ALPSLISV-----GCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKY 166 P +V G +D I IW N+ + A + + +C L K+ Sbjct: 363 WCPWQSNVLATGGGTSDRHIRIW--NVCSGACLSAVDAHSQ------VCSILWSPHYKEL 414 Query: 167 LLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQ 226 + G + I + VAEL+GH V SL +P + S + Sbjct: 415 ISGHGFAQNQLVIWKY-------PTMAKVAELKGHTSRVLSLTM----SPDGATVASAAA 463 Query: 227 DRYIRLWR 234 D +RLWR Sbjct: 464 DETLRLWR 471 Score = 35.0 bits (79), Expect = 0.13, Method: Compositional matrix adjust. Identities = 47/216 (21%), Positives = 75/216 (34%), Gaps = 37/216 (17%) Query: 208 LAFRHQETPGDYL-----------LCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSN 256 L E PG+Y+ L G+ ++LW ++ + + S ++ LS Sbjct: 217 LQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW 276 Query: 257 KQYKFQIDD--------ELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVW 308 Y ++RV + A + GH + L+W L + D + VW Sbjct: 277 NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW 336 Query: 309 EPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSW--RM 366 G WV + +GA A W C W + + T G T R+ Sbjct: 337 PSAPGEGGWVPLQTFTQH--QGAVKAVA-----W-CPW----QSNVLATGGGTSDRHIRI 384 Query: 367 WATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLA 402 W N+ L A V I WSP + L++ Sbjct: 385 W----NVCSGACLSAVDAHSQVCSILWSPHYKELIS 416 Score = 33.1 bits (74), Expect = 0.46, Method: Compositional matrix adjust. Identities = 52/264 (19%), Positives = 102/264 (38%), Gaps = 37/264 (14%) Query: 62 VTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGC 121 ++ V ++ + +++ + V++W D + ++ + +S + +LS ++S G Sbjct: 229 ISSVAWIKEGNYLAVGTSSAEVQLW---DVQQQKRLRNMTSHSARVGSLSWNSYILSSGS 285 Query: 122 ADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTN-VNVFIA 180 G I +D H G +C L + ++L + G N VNV+ Sbjct: 286 RSGHIH------HHDVRVAEHHVATLSGHSQEVC-GLRWAPDGRHLASGGNDNLVNVWP- 337 Query: 181 SFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDL 240 S G + H+ VK++A+ ++ G+ DR+IR+W + Sbjct: 338 ----SAPGEGGWVPLQTFTQHQGAVKAVAWCPWQS-NVLATGGGTSDRHIRIWNVCSGAC 392 Query: 241 IDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFE---------------ALIMGHDDWIS 285 + + S+ ++L + YK EL G F A + GH + Sbjct: 393 LSAVDAHSQVCSILWSPHYK-----ELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVL 447 Query: 286 SLQWHESRLQLLAATADTSLMVWE 309 SL + +A AD +L +W Sbjct: 448 SLTMSPDGATVASAAADETLRLWR 471 >6ID0-T nrPDB Length = 514 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 70/307 (22%), Positives = 119/307 (38%), Gaps = 51/307 (16%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 V A +TI +WD K +L GH + V V S ++ S ED VK W Sbjct: 219 FVTGSADRTIKIWDLASGKLK---LSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWD- 274 Query: 89 TDYSHLQCIQTIQHYSKTIVALSAL---PSL-ISVGCA-DGTISIWRQNIQNDEFGLAHE 143 L+ + I+HY + A+ L P++ + V C+ D T IW + L+ Sbjct: 275 -----LEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLS-- 327 Query: 144 FTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHED 203 G + + E + + T + ++ D K RV L H+ Sbjct: 328 -----GHTNAVATVRCQAAEPQIITGSHDTTIRLW-------DLVAGKTRVT--LTNHKK 373 Query: 204 WVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDS---KKLTLLSNKQYK 260 V+++ P Y SGS D I+ W+ I + + LT+ S+ Sbjct: 374 SVRAVVLH----PRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLV 428 Query: 261 FQIDD------ELRVGINFEAL-------IMGHDDWISSLQWHESRLQLLAATADTSLMV 307 D+ + R G NF+ + + + I + + +S +LL A AD ++ V Sbjct: 429 SGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKV 488 Query: 308 WEPDETS 314 + D+T+ Sbjct: 489 YREDDTA 495 Score = 35.0 bits (79), Expect = 0.13, Method: Compositional matrix adjust. Identities = 31/103 (30%), Positives = 45/103 (43%), Gaps = 8/103 (7%) Query: 28 KIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWK 87 +I+ TI LWD + + TL H+ V V P S S D+ +K WK Sbjct: 344 QIITGSHDTTIRLWDLVAGKTR---VTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWK 399 Query: 88 FTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCAD-GTISIW 129 F D S IQ + ++ I L+ + V AD GT+ +W Sbjct: 400 FPDGS---FIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLW 439 Score = 34.3 bits (77), Expect = 0.23, Method: Compositional matrix adjust. Identities = 47/211 (22%), Positives = 82/211 (38%), Gaps = 40/211 (18%) Query: 522 ETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQK--LIASACRS 579 ET + + + + P + Q H W + GH + C+ + P + + SA R+ Sbjct: 168 ETGNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRT 227 Query: 580 NNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMED 639 I+I+ + ++K +L H T+ + S +L S D++ W D Sbjct: 228 -------IKIWDLASG-KLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCW-----D 274 Query: 640 NTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIK 699 + ++ H ++ D P +V VT SRD T ++W D +AS+ Sbjct: 275 LEYNKVIRHYHGHLSAVYGLDLHPTI--DVLVTCSRDSTARIW--------DVRTKASVH 324 Query: 700 ----HTKAVTAISI-----------HDSMIR 715 HT AV + HD+ IR Sbjct: 325 TLSGHTNAVATVRCQAAEPQIITGSHDTTIR 355 Score = 32.7 bits (73), Expect = 0.67, Method: Compositional matrix adjust. Identities = 25/121 (20%), Positives = 52/121 (42%), Gaps = 13/121 (10%) Query: 198 LEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDL---IDDSEEDSKKLTLL 254 + GH WV+ +A PG+ +GS DR I++W + L + + + + Sbjct: 200 ISGHLGWVRCIAVE----PGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVS 255 Query: 255 SNKQYKFQIDDELRVG---INFEALIM---GHDDWISSLQWHESRLQLLAATADTSLMVW 308 + Y F ++ +V + + +I GH + L H + L+ + D++ +W Sbjct: 256 TRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIW 315 Query: 309 E 309 + Sbjct: 316 D 316 >6N9G-C nrPDB Length = 353 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 66/308 (21%), Positives = 109/308 (35%), Gaps = 66/308 (21%) Query: 54 TLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIW-KFTDYSHLQCIQTIQHYSKTIVALSA 112 TLKGH +V C+ + D +VS+S+D V +W FT + ++A + Sbjct: 58 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKE----HAVTMPCTWVMACAY 113 Query: 113 LPSLISVGCA--DGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSK---------- 160 PS ++ C D S++ +E A + ++ Y S + Sbjct: 114 APSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASG 173 Query: 161 --------VEEKKYLLAIGGTNVNVFIASFILSDSG----------------IEKCRVVA 196 VE + L + G +V S++G + + V Sbjct: 174 DGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQ 233 Query: 197 ELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRIND----------LIDDSEE 246 E HE V S+ + P SGS D RL+ +R + + S Sbjct: 234 AFETHESDVNSVRYY----PSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSV 289 Query: 247 D---SKKLTLLSNKQYKFQIDDEL---RVGINFEALIMGHDDWISSLQWHESRLQLLAAT 300 D S +L Y + D L RV I F GH++ +S+L+ + + Sbjct: 290 DFSLSGRLLFAGYNDYTINVWDVLKGSRVSILF-----GHENRVSTLRVSPDGTAFCSGS 344 Query: 301 ADTSLMVW 308 D +L VW Sbjct: 345 WDHTLRVW 352 Score = 37.0 bits (84), Expect = 0.034, Method: Compositional matrix adjust. Identities = 29/116 (25%), Positives = 43/116 (37%), Gaps = 5/116 (4%) Query: 567 SPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCR 626 +P IA N + EN K ++ H+ ++ F+ +L+ Sbjct: 114 APSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASG 173 Query: 627 DRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVW 682 D ALW+ +E F H + D AP E GN FV+ DK VW Sbjct: 174 DGTCALWD--VESGQLLQSFHG---HGADVLCLDLAPSETGNTFVSGGCDKKAMVW 224 Score = 35.0 bits (79), Expect = 0.13, Method: Compositional matrix adjust. Identities = 17/50 (34%), Positives = 27/50 (54%), Gaps = 3/50 (6%) Query: 37 TIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIW 86 TI +WD ++ + + L GHE V+ +R PD S S DH +++W Sbjct: 306 TINVWDVLKGSRVSI---LFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352 >4V7E-Bg nrPDB Length = 380 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 54/235 (22%), Positives = 93/235 (39%), Gaps = 50/235 (21%) Query: 21 SDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASED 80 +D+ K K G+T ++P + TL+GH +V + + P+ +++VSAS+D Sbjct: 35 TDVEKYSK----AQGRTAVSFNPTDLV---CCRTLQGHSGKVYSLDWTPEKNWIVSASQD 87 Query: 81 HHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCA--DGTISIWRQNIQNDEF 138 + +W Q I+ + ++ + P+ SV C D SI+ + Q D Sbjct: 88 GRLIVWNALTS---QKTHAIKLHCPWVMECAFAPNGQSVACGGLDSACSIFNLSSQADRD 144 Query: 139 G---LAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIG-------------GTNVNVFIASF 182 G ++ T KG+ S V +++ L G G +++F + F Sbjct: 145 GNMPVSRVLTGHKGYAS----SCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEF 200 Query: 183 ILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRI 237 GH V SL+ + SGS D +RLW +RI Sbjct: 201 P---------------SGHTADVLSLSINSLNAN---MFISGSCDTTVRLWDLRI 237 Score = 32.7 bits (73), Expect = 0.59, Method: Compositional matrix adjust. Identities = 25/99 (25%), Positives = 42/99 (42%), Gaps = 8/99 (8%) Query: 37 TIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQC 96 T+ LWD + ++ V T GHE ++ V+F PD + S+D +++ LQ Sbjct: 229 TVRLWD-LRITSRAVR-TYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQV 286 Query: 97 IQTIQHYSK------TIVALSALPSLISVGCADGTISIW 129 + T VA S L+ G ++G +W Sbjct: 287 YNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVW 325 Score = 30.0 bits (66), Expect = 4.2, Method: Compositional matrix adjust. Identities = 10/34 (29%), Positives = 19/34 (55%) Query: 58 HEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDY 91 HE ++C+ D + + S D ++KIW F+ + Sbjct: 343 HEGRISCLGLSSDGSALCTGSWDKNLKIWAFSGH 376 Score = 29.3 bits (64), Expect = 7.3, Method: Compositional matrix adjust. Identities = 27/116 (23%), Positives = 46/116 (39%), Gaps = 12/116 (10%) Query: 48 NKGVYATLKGHEAEVTCVRFVPDSDF-MVSASEDHHVKIWKFTDYSHLQCI-------QT 99 N V L GH+ + ++VPD + +++ S D +W T + T Sbjct: 146 NMPVSRVLTGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHT 205 Query: 100 IQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGL--AHEFTIKKGFFYP 153 S +I +L+A ++ G D T+ +W I + HE I F+P Sbjct: 206 ADVLSLSINSLNA--NMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINSVKFFP 259 >4GGA-A nrPDB Length = 420 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 47/188 (25%), Positives = 73/188 (38%), Gaps = 25/188 (13%) Query: 53 ATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFT-DYSHLQCIQTIQHYSKTIVALS 111 ATL GH EV +R+ PD + S D+ V +W +QT + + A++ Sbjct: 224 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 283 Query: 112 ALPSLISV-----GCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKY 166 P +V G +D I IW N+ + A + + +C L K+ Sbjct: 284 WCPWQSNVLATGGGTSDRHIRIW--NVCSGACLSAVDAHSQ------VCSILWSPHYKEL 335 Query: 167 LLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQ 226 + G + I + VAEL+GH V SL +P + S + Sbjct: 336 ISGHGFAQNQLVIWKY-------PTMAKVAELKGHTSRVLSLTM----SPDGATVASAAA 384 Query: 227 DRYIRLWR 234 D +RLWR Sbjct: 385 DETLRLWR 392 Score = 34.7 bits (78), Expect = 0.19, Method: Compositional matrix adjust. Identities = 47/216 (21%), Positives = 75/216 (34%), Gaps = 37/216 (17%) Query: 208 LAFRHQETPGDYL-----------LCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSN 256 L E PG+Y+ L G+ ++LW ++ + + S ++ LS Sbjct: 138 LQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW 197 Query: 257 KQYKFQIDD--------ELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVW 308 Y ++RV + A + GH + L+W L + D + VW Sbjct: 198 NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW 257 Query: 309 EPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSW--RM 366 G WV + +GA A W C W + + T G T R+ Sbjct: 258 PSAPGEGGWVPLQTFTQH--QGAVKAVA-----W-CPW----QSNVLATGGGTSDRHIRI 305 Query: 367 WATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLA 402 W N+ L A V I WSP + L++ Sbjct: 306 W----NVCSGACLSAVDAHSQVCSILWSPHYKELIS 337 Score = 32.3 bits (72), Expect = 0.74, Method: Compositional matrix adjust. Identities = 52/264 (19%), Positives = 102/264 (38%), Gaps = 37/264 (14%) Query: 62 VTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGC 121 ++ V ++ + +++ + V++W D + ++ + +S + +LS ++S G Sbjct: 150 ISSVAWIKEGNYLAVGTSSAEVQLW---DVQQQKRLRNMTSHSARVGSLSWNSYILSSGS 206 Query: 122 ADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTN-VNVFIA 180 G I +D H G +C L + ++L + G N VNV+ Sbjct: 207 RSGHIH------HHDVRVAEHHVATLSGHSQEVC-GLRWAPDGRHLASGGNDNLVNVWP- 258 Query: 181 SFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDL 240 S G + H+ VK++A+ ++ G+ DR+IR+W + Sbjct: 259 ----SAPGEGGWVPLQTFTQHQGAVKAVAWCPWQS-NVLATGGGTSDRHIRIWNVCSGAC 313 Query: 241 IDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFE---------------ALIMGHDDWIS 285 + + S+ ++L + YK EL G F A + GH + Sbjct: 314 LSAVDAHSQVCSILWSPHYK-----ELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVL 368 Query: 286 SLQWHESRLQLLAATADTSLMVWE 309 SL + +A AD +L +W Sbjct: 369 SLTMSPDGATVASAAADETLRLWR 392 >5LCW-Q nrPDB Length = 374 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 47/188 (25%), Positives = 73/188 (38%), Gaps = 25/188 (13%) Query: 53 ATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFT-DYSHLQCIQTIQHYSKTIVALS 111 ATL GH EV +R+ PD + S D+ V +W +QT + + A++ Sbjct: 178 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 237 Query: 112 ALPSLISV-----GCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKY 166 P +V G +D I IW N+ + A + + +C L K+ Sbjct: 238 WCPWQSNVLATGGGTSDRHIRIW--NVCSGACLSAVDAHSQ------VCSILWSPHYKEL 289 Query: 167 LLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQ 226 + G + I + VAEL+GH V SL +P + S + Sbjct: 290 ISGHGFAQNQLVIWKY-------PTMAKVAELKGHTSRVLSLTM----SPDGATVASAAA 338 Query: 227 DRYIRLWR 234 D +RLWR Sbjct: 339 DETLRLWR 346 Score = 34.3 bits (77), Expect = 0.24, Method: Compositional matrix adjust. Identities = 47/216 (21%), Positives = 75/216 (34%), Gaps = 37/216 (17%) Query: 208 LAFRHQETPGDYL-----------LCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSN 256 L E PG+Y+ L G+ ++LW ++ + + S ++ LS Sbjct: 92 LQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW 151 Query: 257 KQYKFQIDD--------ELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVW 308 Y ++RV + A + GH + L+W L + D + VW Sbjct: 152 NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW 211 Query: 309 EPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSW--RM 366 G WV + +GA A W C W + + T G T R+ Sbjct: 212 PSAPGEGGWVPLQTFTQH--QGAVKAVA-----W-CPW----QSNVLATGGGTSDRHIRI 259 Query: 367 WATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLA 402 W N+ L A V I WSP + L++ Sbjct: 260 W----NVCSGACLSAVDAHSQVCSILWSPHYKELIS 291 Score = 32.3 bits (72), Expect = 0.74, Method: Compositional matrix adjust. Identities = 52/264 (19%), Positives = 102/264 (38%), Gaps = 37/264 (14%) Query: 62 VTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGC 121 ++ V ++ + +++ + V++W D + ++ + +S + +LS ++S G Sbjct: 104 ISSVAWIKEGNYLAVGTSSAEVQLW---DVQQQKRLRNMTSHSARVGSLSWNSYILSSGS 160 Query: 122 ADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTN-VNVFIA 180 G I +D H G +C L + ++L + G N VNV+ Sbjct: 161 RSGHIH------HHDVRVAEHHVATLSGHSQEVC-GLRWAPDGRHLASGGNDNLVNVWP- 212 Query: 181 SFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDL 240 S G + H+ VK++A+ ++ G+ DR+IR+W + Sbjct: 213 ----SAPGEGGWVPLQTFTQHQGAVKAVAWCPWQS-NVLATGGGTSDRHIRIWNVCSGAC 267 Query: 241 IDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFE---------------ALIMGHDDWIS 285 + + S+ ++L + YK EL G F A + GH + Sbjct: 268 LSAVDAHSQVCSILWSPHYK-----ELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVL 322 Query: 286 SLQWHESRLQLLAATADTSLMVWE 309 SL + +A AD +L +W Sbjct: 323 SLTMSPDGATVASAAADETLRLWR 346 >3JRO-A nrPDB Length = 753 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 61/247 (24%), Positives = 105/247 (42%), Gaps = 29/247 (11%) Query: 27 KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPD--SDFMVSASEDHHVK 84 K++ + KTI +++ +E + TL GHE V V + + S S D V Sbjct: 22 KRLATCSSDKTIKIFE-VEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 Query: 85 IWKFTDYSHLQCIQTIQHYSKTIVALSALP----SLISVGCADGTISI--WRQNIQNDEF 138 IWK + Q H S ++ ++ P L+ V +DG +S+ +++N Sbjct: 81 IWKEENGRWSQIAVHAVH-SASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPI 139 Query: 139 GL-AHEFTIKKGFFYPLCLSL-----SKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKC 192 + AH + + P + E +K++ GG + V I + +S + Sbjct: 140 IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFV--TGGADNLVKIWKY---NSDAQTY 194 Query: 193 RVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLT 252 + + LEGH DWV+ +A+ Y L S SQDR +W D+E+ K T Sbjct: 195 VLESTLEGHSDWVRDVAWSPTVLLRSY-LASVSQDRTCIIW-------TQDNEQGPWKKT 246 Query: 253 LLSNKQY 259 LL +++ Sbjct: 247 LLKEEKF 253 Score = 34.7 bits (78), Expect = 0.19, Method: Compositional matrix adjust. Identities = 18/68 (26%), Positives = 32/68 (47%), Gaps = 2/68 (2%) Query: 620 FLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTV 679 +L SV +DR +W ++ E ++ E+ ++W A W+ GNV + D V Sbjct: 221 YLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSL--SGNVLALSGGDNKV 278 Query: 680 KVWRHQKE 687 +W+ E Sbjct: 279 TLWKENLE 286 Score = 32.3 bits (72), Expect = 0.77, Method: Compositional matrix adjust. Identities = 18/68 (26%), Positives = 32/68 (47%), Gaps = 6/68 (8%) Query: 257 KQYKFQIDDELRVGINFEALIMGHDDWISSLQWHES---RLQLLAATADTSLMVWEPDET 313 K +K+ D + V E+ + GH DW+ + W + R L + + D + ++W D Sbjct: 183 KIWKYNSDAQTYV---LESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNE 239 Query: 314 SGIWVCSL 321 G W +L Sbjct: 240 QGPWKKTL 247 Score = 31.6 bits (70), Expect = 1.4, Method: Compositional matrix adjust. Identities = 19/68 (27%), Positives = 32/68 (47%), Gaps = 3/68 (4%) Query: 618 GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDK 677 GK L + D+ ++E +E T +L H +W DWA +FG + + S D Sbjct: 21 GKRLATCSSDKTIKIFE--VEGETHKL-IDTLTGHEGPVWRVDWAHPKFGTILASCSYDG 77 Query: 678 TVKVWRHQ 685 V +W+ + Sbjct: 78 KVLIWKEE 85 Score = 29.3 bits (64), Expect = 7.2, Method: Compositional matrix adjust. Identities = 20/66 (30%), Positives = 29/66 (43%), Gaps = 3/66 (4%) Query: 616 KDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASR 675 K G L S D K +W+ E+N + H+ + WAP E+G + + AS Sbjct: 65 KFGTILASCSYDGKVLIWK---EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASS 121 Query: 676 DKTVKV 681 D V V Sbjct: 122 DGKVSV 127 Score = 29.3 bits (64), Expect = 7.7, Method: Compositional matrix adjust. Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 2/54 (3%) Query: 670 FVTASRDKTVKVWRHQKEPADDYVLEASIK-HTKAVTAISIHDSMIREKILISV 722 FVT D VK+W++ + A YVLE++++ H+ V ++ +++ L SV Sbjct: 173 FVTGGADNLVKIWKYNSD-AQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASV 225 >4N14-A nrPDB Length = 314 Score = 39.7 bits (91), Expect = 0.005, Method: Compositional matrix adjust. Identities = 47/188 (25%), Positives = 73/188 (38%), Gaps = 25/188 (13%) Query: 53 ATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFT-DYSHLQCIQTIQHYSKTIVALS 111 ATL GH EV +R+ PD + S D+ V +W +QT + + A++ Sbjct: 140 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 199 Query: 112 ALPSLISV-----GCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKY 166 P +V G +D I IW N+ + A + + +C L K+ Sbjct: 200 WCPWQSNVLATGGGTSDRHIRIW--NVCSGACLSAVDAHSQ------VCSILWSPHYKEL 251 Query: 167 LLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQ 226 + G + I + VAEL+GH V SL +P + S + Sbjct: 252 ISGHGFAQNQLVIWKY-------PTMAKVAELKGHTSRVLSLTM----SPDGATVASAAA 300 Query: 227 DRYIRLWR 234 D +RLWR Sbjct: 301 DETLRLWR 308 Score = 33.1 bits (74), Expect = 0.45, Method: Compositional matrix adjust. Identities = 47/216 (21%), Positives = 75/216 (34%), Gaps = 37/216 (17%) Query: 208 LAFRHQETPGDYL-----------LCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSN 256 L E PG+Y+ L G+ ++LW ++ + + S ++ LS Sbjct: 54 LQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW 113 Query: 257 KQYKFQIDD--------ELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVW 308 Y ++RV + A + GH + L+W L + D + VW Sbjct: 114 NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW 173 Query: 309 EPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTG--SWRM 366 G WV + +GA A W C W + + T G T R+ Sbjct: 174 PSAPGEGGWVPLQTFTQH--QGAVKAVA-----W-CPW----QSNVLATGGGTSDRHIRI 221 Query: 367 WATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLA 402 W N+ L A V I WSP + L++ Sbjct: 222 W----NVCSGACLSAVDAHSQVCSILWSPHYKELIS 253 Score = 32.3 bits (72), Expect = 0.81, Method: Compositional matrix adjust. Identities = 52/264 (19%), Positives = 102/264 (38%), Gaps = 37/264 (14%) Query: 62 VTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGC 121 ++ V ++ + +++ + V++W D + ++ + +S + +LS ++S G Sbjct: 66 ISSVAWIKEGNYLAVGTSSAEVQLW---DVQQQKRLRNMTSHSARVGSLSWNSYILSSGS 122 Query: 122 ADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTN-VNVFIA 180 G I +D H G +C L + ++L + G N VNV+ Sbjct: 123 RSGHIH------HHDVRVAEHHVATLSGHSQEVC-GLRWAPDGRHLASGGNDNLVNVWP- 174 Query: 181 SFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDL 240 S G + H+ VK++A+ ++ G+ DR+IR+W + Sbjct: 175 ----SAPGEGGWVPLQTFTQHQGAVKAVAWCPWQS-NVLATGGGTSDRHIRIWNVCSGAC 229 Query: 241 IDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFE---------------ALIMGHDDWIS 285 + + S+ ++L + YK EL G F A + GH + Sbjct: 230 LSAVDAHSQVCSILWSPHYK-----ELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVL 284 Query: 286 SLQWHESRLQLLAATADTSLMVWE 309 SL + +A AD +L +W Sbjct: 285 SLTMSPDGATVASAAADETLRLWR 308 >3JB9-g nrPDB Length = 558 Score = 39.3 bits (90), Expect = 0.006, Method: Compositional matrix adjust. Identities = 46/204 (22%), Positives = 79/204 (38%), Gaps = 34/204 (16%) Query: 22 DIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDH 81 D K + +A A K I +D P+ + H + + F+ + V+ S+D Sbjct: 362 DPDKPNEFLAGTADKRILQFDIRSPD---IVQAYDHHLGGINSITFLENGKRFVTTSDDS 418 Query: 82 HVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIW------RQNIQN 135 ++ W++ ++ + I +S VAL I+ D I ++ RQN Sbjct: 419 SMRFWEYGTPVPIKFVADIAMHSMPRVALRPNGKSIACQSLDNCIYVYSAYEKYRQN--- 475 Query: 136 DEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGI----EK 191 KK F S Y L +G + F+ S S + + Sbjct: 476 -----------KKKVFKGYSCS-------GYSLEVGFSPDGRFVFSGDSSGNACFWDWKT 517 Query: 192 CRVVAELEGHEDWVKSLAFRHQET 215 C+++A+L H V+S+AF QET Sbjct: 518 CKLMAKLPAHSGPVQSMAFHPQET 541 Score = 38.9 bits (89), Expect = 0.009, Method: Compositional matrix adjust. Identities = 27/80 (33%), Positives = 42/80 (52%), Gaps = 7/80 (8%) Query: 54 TLKGHEAEVTCVRFVPDS-DFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSA 112 T KGH ++C+RF P S ++S S D+ +KIW+ Y ++T Q +++ I LS Sbjct: 261 TWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEV--YHDRSLLRTFQGHARPIRDLSF 318 Query: 113 LP---SLISVGCADGTISIW 129 S +S D TI +W Sbjct: 319 SQDGRSFLSTSF-DKTIKLW 337 Score = 33.1 bits (74), Expect = 0.52, Method: Compositional matrix adjust. Identities = 48/218 (22%), Positives = 78/218 (35%), Gaps = 54/218 (24%) Query: 556 GHGFEITCLDISP-DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKF 614 GH I+CL P L+ S N ++ + ++ + L H+ I L F Sbjct: 264 GHTKGISCLRFFPISGHLLLSGSMDNQIK--IWEVYHDRSLLR---TFQGHARPIRDLSF 318 Query: 615 SKDGKFLLSVCRDRKWALWERNMED-----------NTFELRFKNEKPHTRIIWDADWAP 663 S+DG+ LS D+ LW+ + N + + +KP+ + AD Sbjct: 319 SQDGRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGTADKRI 378 Query: 664 LEF--------------------------GNVFVTASRDKTVKVWRHQKEPADDYVLEAS 697 L+F G FVT S D +++ W +Y Sbjct: 379 LQFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFW--------EYGTPVP 430 Query: 698 IKHTKAVTAISIHDSMIRE--KILISVGLENGEIYLYS 733 IK + S+ +R K + L+N IY+YS Sbjct: 431 IKFVADIAMHSMPRVALRPNGKSIACQSLDNC-IYVYS 467 >3ACP-A nrPDB Length = 417 Score = 38.9 bits (89), Expect = 0.008, Method: Compositional matrix adjust. Identities = 22/75 (29%), Positives = 41/75 (54%), Gaps = 3/75 (4%) Query: 56 KGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSK-TIVALSALP 114 + H +E+T ++F P + ++S+S+D +KIW D S+ + + I H + T +A+ Sbjct: 133 QAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTL--IGHRATVTDIAIIDRG 190 Query: 115 SLISVGCADGTISIW 129 + DGTI +W Sbjct: 191 RNVLSASLDGTIRLW 205 Score = 32.0 bits (71), Expect = 1.1, Method: Compositional matrix adjust. Identities = 24/81 (29%), Positives = 41/81 (50%), Gaps = 13/81 (16%) Query: 605 HSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDA---DW 661 H IT+LKF G+ L+S +D + +W +++D + P T I A D Sbjct: 135 HVSEITKLKFFPSGEALISSSQDMQLKIW--SVKDGS--------NPRTLIGHRATVTDI 184 Query: 662 APLEFGNVFVTASRDKTVKVW 682 A ++ G ++AS D T+++W Sbjct: 185 AIIDRGRNVLSASLDGTIRLW 205 >6QX9-4B nrPDB Length = 522 Score = 38.9 bits (89), Expect = 0.009, Method: Compositional matrix adjust. Identities = 61/315 (19%), Positives = 117/315 (37%), Gaps = 76/315 (24%) Query: 57 GHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQ-------TIQHYSKTIVA 109 G + ++ F P+S + +A K+W D + L ++ I + K+ V+ Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288 Query: 110 LSALPSLISVGCADGTISIWRQNIQNDEFGL---AHEFTIKKGFFYP-------LCLSLS 159 L ++ ADG++ +W ++ +DE H + + ++P C S Sbjct: 289 LDPKDVNLASCAADGSVKLW--SLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRS 346 Query: 160 ----KVEEKKYLLAIGGTNVNVFIASF----ILSDSG----------IEKCRVVAELEGH 201 +E ++ +L G ++ V+ +F L+ +G + R + LEGH Sbjct: 347 WRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGH 406 Query: 202 EDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKF 261 + + F +P Y + +GS D ++W +R + Y Sbjct: 407 LKEIYGINF----SPNGYHIATGSGDNTCKVWDLRQRRCV-----------------YTI 445 Query: 262 QIDDELRVGINFE---------------ALIMGHDDW--ISSLQWHESRLQLLAATADTS 304 L G+ FE A I H W + +L HE ++ L ++D Sbjct: 446 PAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQ 505 Query: 305 LMV-WEPDETSGIWV 318 L+ D T +W+ Sbjct: 506 LIATCSYDRTFKLWM 520 Score = 37.7 bits (86), Expect = 0.020, Method: Compositional matrix adjust. Identities = 20/78 (25%), Positives = 35/78 (44%), Gaps = 6/78 (7%) Query: 55 LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP 114 L+GH E+ + F P+ + + S D+ K+W D +C+ TI + + + P Sbjct: 403 LEGHLKEIYGINFSPNGYHIATGSGDNTCKVW---DLRQRRCVYTIPAHQNLVTGVKFEP 459 Query: 115 ---SLISVGCADGTISIW 129 + + G D T IW Sbjct: 460 IHGNFLLTGAYDNTAKIW 477 Score = 35.4 bits (80), Expect = 0.097, Method: Compositional matrix adjust. Identities = 19/78 (24%), Positives = 39/78 (50%), Gaps = 7/78 (8%) Query: 605 HSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPL 664 H++ + R+ + G+FL + C DR W LW+ ++ +++ H+ ++D A Sbjct: 322 HTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEIL-----HQEGHSMGVYDI--AFH 374 Query: 665 EFGNVFVTASRDKTVKVW 682 + G++ T D +VW Sbjct: 375 QDGSLAGTGGLDAFGRVW 392 Score = 35.4 bits (80), Expect = 0.099, Method: Compositional matrix adjust. Identities = 50/233 (21%), Positives = 91/233 (39%), Gaps = 45/233 (19%) Query: 362 GSWRMWAT-KDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDAS 420 GS ++W+ D + D I G T V + W PSG +L T D++ RL+ Sbjct: 303 GSVKLWSLDSDEPVAD----IEGHTVRVARVMWHPSGRFLGTTCYDRSWRLW-------- 350 Query: 421 GRKREIATWHEFSRPQIHGYDMICVETVTDTRFV-SGGDEKILRSFDLPKG-----VAGM 474 ++ E + H + + D +GG + R +DL G + G Sbjct: 351 ----DLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGH 406 Query: 475 LQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLE 534 L++ GI F P+ + + +G++ D + P + ++ ++ Sbjct: 407 LKEIYGINFS-----PNGYHI-----ATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVK 456 Query: 535 CPPMED------------QLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIAS 575 P+ ++ H W ++ L GH ++ LDIS D +LIA+ Sbjct: 457 FEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIAT 509 Score = 29.6 bits (65), Expect = 5.9, Method: Compositional matrix adjust. Identities = 18/83 (21%), Positives = 33/83 (39%), Gaps = 6/83 (7%) Query: 602 LPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADW 661 L H I + FS +G + + D +W+ + + H ++ + Sbjct: 403 LEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTI-----PAHQNLVTGVKF 457 Query: 662 APLEFGNVFVTASRDKTVKVWRH 684 P+ GN +T + D T K+W H Sbjct: 458 EPIH-GNFLLTGAYDNTAKIWTH 479 >6EOJ-D nrPDB Length = 470 Score = 38.5 bits (88), Expect = 0.010, Method: Compositional matrix adjust. Identities = 42/183 (22%), Positives = 78/183 (42%), Gaps = 22/183 (12%) Query: 55 LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP 114 ++ H++ VT +++ DSD+M+S D +KIW+ ++S ++ I S +A S+ Sbjct: 131 MQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ-PNFSMVKEIDAAHTESIRDMAFSSND 189 Query: 115 SLISVGCADGTISIWR-QNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGT 173 S D + IW N + + H + +K ++P + L K L+ + Sbjct: 190 SKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPE-MGLIASASKDNLVKLWDP 248 Query: 174 NVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW 233 I+S + + K R Q T G+ LL + S+D+ R++ Sbjct: 249 RSGNCISSILKFKHTVLKTRF------------------QPTKGN-LLMAISKDKSCRVF 289 Query: 234 RIR 236 IR Sbjct: 290 DIR 292 Score = 35.4 bits (80), Expect = 0.095, Method: Compositional matrix adjust. Identities = 39/163 (23%), Positives = 71/163 (43%), Gaps = 23/163 (14%) Query: 273 FEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPD-----ETSGIWVCSLRLGEMS 327 FE L+ HD ++++++ +++ AD + +W+P+ E S+R S Sbjct: 127 FETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFS 186 Query: 328 SKGASTATGSSGGFWSCLWFTHERMDFFLT----NGKTGSWR------MWATKDNIIC-- 375 S + T S F++ + + L+ + K+ W A+KDN++ Sbjct: 187 SNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW 246 Query: 376 DQRLG--ISGATK---DVTDIAWSPS-GEYLLATSLDQTTRLF 412 D R G IS K V + P+ G L+A S D++ R+F Sbjct: 247 DPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVF 289 Score = 32.0 bits (71), Expect = 1.2, Method: Compositional matrix adjust. Identities = 43/210 (20%), Positives = 86/210 (40%), Gaps = 55/210 (26%) Query: 554 LYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPF-HSLTITRL 612 L GH +++ D P+ LIASA + N +++++ + I L F H++ TR Sbjct: 215 LSGHHWDVKSCDWHPEMGLIASASKDN-----LVKLWDPRSGNCISSILKFKHTVLKTRF 269 Query: 613 KFSKDGKFLLSVCRDRKWALWE-----------RNMED---------------------- 639 + +K G L+++ +D+ +++ R+ D Sbjct: 270 QPTK-GNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGS 328 Query: 640 -NTFELRFKNEKP-------HTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADD 691 F+L +P H + I + P+ G++F TA++D+T++ W + P D Sbjct: 329 LKHFDLLQNLNEPILTIPYAHDKCITSLSYNPV--GHIFATAAKDRTIRFWTRAR-PIDP 385 Query: 692 YVLEASIKHTKAVT----AISIHDSMIREK 717 + + K + I+ + +REK Sbjct: 386 NAYDDPTYNNKKINGWFFGINNDINAVREK 415 Score = 30.0 bits (66), Expect = 4.0, Method: Compositional matrix adjust. Identities = 21/78 (26%), Positives = 38/78 (48%), Gaps = 7/78 (8%) Query: 605 HSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPL 664 H +T +K+S D +++S D +W+ N F + + + HT I D ++ Sbjct: 134 HDSAVTTMKYSHDSDWMISGDADGMIKIWQPN-----FSMVKEIDAAHTESIRDMAFSSN 188 Query: 665 EFGNVFVTASRDKTVKVW 682 + + FVT S D +K+W Sbjct: 189 D--SKFVTCSDDNILKIW 204 >5WBU-D nrPDB Length = 328 Score = 38.5 bits (88), Expect = 0.013, Method: Compositional matrix adjust. Identities = 46/224 (20%), Positives = 88/224 (39%), Gaps = 21/224 (9%) Query: 15 NKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFM 74 + Q ++ + ++A + I ++D + NN + G + V F D +M Sbjct: 44 DSQVNALEVTPDRSMIAAAGYQHIRMYD-LNSNNPNPIISYDGVNKNIASVGFHEDGRWM 102 Query: 75 VSASEDHHVKIWKFTDYSHLQCIQTIQ-HYSKTIVALSALPSLISVGCADGTISIWR-QN 132 + ED +IW +LQC + Q + V L + + VG G I IW + Sbjct: 103 YTGGEDCTARIWDLRS-RNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKT 161 Query: 133 IQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKC 192 N++ E +I P + Y+ A+ T N ++ + + G E Sbjct: 162 DHNEQLIPEPEVSITSAHIDP---------DASYMAAVNSTG-NCYVWN-LTGGIGDEVT 210 Query: 193 RVV--AELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWR 234 +++ ++ H + F +P LL + S D+ ++WR Sbjct: 211 QLIPKTKIPAHTRYALQCRF----SPDSTLLATCSADQTCKIWR 250 Score = 36.6 bits (83), Expect = 0.049, Method: Compositional matrix adjust. Identities = 45/176 (25%), Positives = 65/176 (36%), Gaps = 23/176 (13%) Query: 547 LWPEVEKLYGHGFEITCLDISPDQKLIASACRSNN--VQNAVIRIFSTENWLEIKPALPF 604 L PE E IT I PD +A+ + N V N I L K +P Sbjct: 167 LIPEPE------VSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPA 220 Query: 605 HSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKP-HTRIIWDADWAP 663 H+ + +FS D L + D+ +W + EL K+ P + W A Sbjct: 221 HTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAF 280 Query: 664 LEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIK-----HTKAVTAISIHDSMI 714 VTAS D ++W V IK H KAV ++ +DS++ Sbjct: 281 SGDSQYIVTASSDNLARLW---------CVETGEIKREYGGHQKAVVCLAFNDSVL 327 Score = 31.2 bits (69), Expect = 2.0, Method: Compositional matrix adjust. Identities = 11/28 (39%), Positives = 17/28 (60%) Query: 65 VRFVPDSDFMVSASEDHHVKIWKFTDYS 92 RF PDS + + S D KIW+ +++S Sbjct: 228 CRFSPDSTLLATCSADQTCKIWRTSNFS 255 >3JB9-L nrPDB Length = 340 Score = 38.1 bits (87), Expect = 0.014, Method: Compositional matrix adjust. Identities = 25/76 (32%), Positives = 39/76 (51%), Gaps = 5/76 (6%) Query: 56 KGHEAEVTCVRFVP-DSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQH-YSKTIVALSAL 113 KGH V + + S+ + S S+D +K+W D CI+TI+ Y T VA++ Sbjct: 132 KGHAGVVNALDVLKVGSELLTSVSDDCTMKVW---DSRSKDCIKTIEEKYPLTAVAIAQQ 188 Query: 114 PSLISVGCADGTISIW 129 + + +G DG I IW Sbjct: 189 GTQVFIGGIDGAIKIW 204 Score = 36.2 bits (82), Expect = 0.062, Method: Compositional matrix adjust. Identities = 63/291 (21%), Positives = 108/291 (37%), Gaps = 74/291 (25%) Query: 33 GAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYS 92 G + I LW+ Y L G + +T +++ DS + +S D H+ W D Sbjct: 69 GMDRQILLWNVFGDVKN--YGVLNGCKGAITDLQWSRDSRVVYCSSSDTHLMSW---DAV 123 Query: 93 HLQCIQTIQHYSKTIVALSAL---PSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKG 149 Q I+ + ++ + AL L L++ D T+ +W ++ Sbjct: 124 SGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRSKD-------------- 169 Query: 150 FFYPLCLSLSKVEEKKYLL---AIGGTNVNVFIASFILSDSGIE-------KCRVVAELE 199 C+ K E+KY L AI VFI D I+ C V L+ Sbjct: 170 -----CI---KTIEEKYPLTAVAIAQQGTQVFIGGI---DGAIKIWDLRNNHCSHV--LK 216 Query: 200 GHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQY 259 GH+D + SLA + L S S D +R++ ++ ++ Q Sbjct: 217 GHKDIITSLAISKDGSS----LLSNSMDNTVRIFDVK----------------PFASAQR 256 Query: 260 KFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEP 310 + QI FE I G + + + W + + A ++D ++ VW Sbjct: 257 QLQI---------FEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVWSA 298 Score = 35.4 bits (80), Expect = 0.090, Method: Compositional matrix adjust. Identities = 28/101 (27%), Positives = 49/101 (48%), Gaps = 11/101 (10%) Query: 359 GKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYD 418 G G+ ++W ++N C L G +T +A S G LL+ S+D T R+F + Sbjct: 196 GIDGAIKIWDLRNNH-CSHVL--KGHKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFA 252 Query: 419 ASGRKREIATWHEFSRPQIHG--YDMICVETVTDTRFVSGG 457 ++ R+ +I IHG ++++ V ++RFV G Sbjct: 253 SAQRQLQIF------EGAIHGQEHNLLGVAWSRNSRFVGAG 287 >5WJC-A nrPDB Length = 430 Score = 37.7 bits (86), Expect = 0.019, Method: Compositional matrix adjust. Identities = 23/61 (37%), Positives = 31/61 (50%), Gaps = 3/61 (4%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVP-DSDFMVSASEDHHVKIWK 87 + A KT+ALWD P + TL+GHE EV + + P D + S+S D V IW Sbjct: 297 LATASADKTVALWDLRNPYQR--LHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWD 354 Query: 88 F 88 Sbjct: 355 L 355 Score = 33.5 bits (75), Expect = 0.41, Method: Compositional matrix adjust. Identities = 61/278 (21%), Positives = 102/278 (36%), Gaps = 61/278 (21%) Query: 53 ATLKGHEAEVTCVRFVPD-SDFMVSASEDHHVKIW-----KFTDYSHLQCIQTIQHYSKT 106 A LKGH AE + + P+ + + +ED + +W FT S + I I Y + Sbjct: 176 AVLKGHTAEGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTS-SETKVISPIAKYHRH 234 Query: 107 IVALSALP------SLISVGCADGTISIWRQNIQNDEFG----LAHEFTIKKGFFYPLCL 156 ++ + +L++ D T+ I + +E AH I P Sbjct: 235 TDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPF-- 292 Query: 157 SLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETP 216 YLLA + V + + + LEGHED V L + + P Sbjct: 293 -------NDYLLATASADKTVALWDLR------NPYQRLHTLEGHEDEVYGLEWSPHDEP 339 Query: 217 GDYLLCSGSQDRYIRLW---RIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINF 273 +L S S DR + +W +I +D+E+ S +L + Sbjct: 340 ---ILASSSTDRRVCIWDLEKIGEEQTPEDAEDGSPELLFMHG----------------- 379 Query: 274 EALIMGHDDWISSLQWHESRLQLLAATADTS-LMVWEP 310 GH + IS W + ++ + AD + L +W P Sbjct: 380 -----GHTNRISEFSWCPNERWVVGSLADDNILQIWSP 412 >4XYI-A nrPDB Length = 430 Score = 37.7 bits (86), Expect = 0.019, Method: Compositional matrix adjust. Identities = 34/131 (25%), Positives = 60/131 (45%), Gaps = 32/131 (24%) Query: 198 LEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW---RIRINDLIDDSEEDSKKLTLL 254 LEGHED V ++ + + P +L + S DR + +W +I ++DSE+ + +L + Sbjct: 321 LEGHEDEVYNVQWSPHDEP---ILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFM 377 Query: 255 SNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTS-LMVWEPDET 313 GH + +S L W+ + +LA+ AD + L +W P + Sbjct: 378 HG----------------------GHTNRVSDLSWNPNNKWVLASLADDNILQIWSPSKV 415 Query: 314 SGIWVC-SLRL 323 IW SL++ Sbjct: 416 --IWASDSLKI 424 Score = 35.0 bits (79), Expect = 0.13, Method: Compositional matrix adjust. Identities = 33/144 (22%), Positives = 60/144 (41%), Gaps = 14/144 (9%) Query: 37 TIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMV-SASEDHHVKIWKFTDYSHLQ 95 T+ + D P++ +K HE V V F P +D+++ +AS DH V +W + Q Sbjct: 259 TLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLN--Q 316 Query: 96 CIQTIQHYSKTIVALSALP---SLISVGCADGTISIW-------RQNIQNDEFGLAHEFT 145 + T++ + + + P ++ D + +W Q +++ E G A E Sbjct: 317 RLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDG-APELM 375 Query: 146 IKKGFFYPLCLSLSKVEEKKYLLA 169 G LS K++LA Sbjct: 376 FMHGGHTNRVSDLSWNPNNKWVLA 399 >3ODT-A nrPDB Length = 313 Score = 37.4 bits (85), Expect = 0.024, Method: Compositional matrix adjust. Identities = 28/88 (31%), Positives = 46/88 (52%), Gaps = 3/88 (3%) Query: 44 IEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHY 103 ++ + V T +GHE+ V C++ +P+ D +VS ED V+IW + S Q I T+ Sbjct: 210 VDMHTGDVLRTYEGHESFVYCIKLLPNGD-IVSCGEDRTVRIWSKENGSLKQVI-TLPAI 267 Query: 104 SKTIVALSALPSLISVGCADGTISIWRQ 131 S V + +I VG +D + I+ Q Sbjct: 268 SIWSVDCMSNGDII-VGSSDNLVRIFSQ 294 Score = 33.1 bits (74), Expect = 0.44, Method: Compositional matrix adjust. Identities = 16/39 (41%), Positives = 23/39 (58%), Gaps = 1/39 (2%) Query: 648 NEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQK 686 N + H +WDA N F+TAS DKT+K+W++ K Sbjct: 137 NLQAHNASVWDAKVVSFS-ENKFLTASADKTIKLWQNDK 174 >6E29-D nrPDB Length = 345 Score = 37.4 bits (85), Expect = 0.026, Method: Compositional matrix adjust. Identities = 40/156 (25%), Positives = 68/156 (43%), Gaps = 13/156 (8%) Query: 605 HSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPL 664 HS IT L +S+ G++LLS C+ K LW+ E+RF+ ++ A+ P Sbjct: 66 HSKNITSLSWSRCGRYLLSACQGWKVILWDLQDGKRYREVRFRAP------VYGAELHPW 119 Query: 665 EFGNVFVTASRDKTVKVWRHQKEPAD-DYVLEASIKHTKAVTAISIHDSMIRE--KILIS 721 D+ + V EP + YVL + K T T ++ + +E K + + Sbjct: 120 NHHQFAAALFEDQPMLV--DITEPVEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTT 177 Query: 722 --VGLENGEIYLYSYTLGKFELITQLNEDITPADKI 755 V +G+ L T G+ +I +I ++KI Sbjct: 178 AIVYTASGDHLLAGTTKGRLNIIDARTREIIYSEKI 213 Score = 32.3 bits (72), Expect = 0.86, Method: Compositional matrix adjust. Identities = 18/49 (36%), Positives = 25/49 (51%), Gaps = 3/49 (6%) Query: 63 TCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALS 111 TCVRF DF+ S D V IW D + + ++ +SK I +LS Sbjct: 29 TCVRFNRKGDFLASGRVDGTVVIW---DLETMGVARKLRGHSKNITSLS 74 >3C9C-A nrPDB Length = 432 Score = 37.0 bits (84), Expect = 0.030, Method: Compositional matrix adjust. Identities = 52/227 (22%), Positives = 96/227 (42%), Gaps = 29/227 (12%) Query: 37 TIALWD----PIEPNNKGVYATLKGHEAEVTCVRF-VPDSDFMVSASEDHHVKIWKFTDY 91 TI LWD P E GH A V V + + S ++D + IW + Sbjct: 207 TICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNN 266 Query: 92 SHLQCIQTIQHYSKTIVALSALPS---LISVGCADGTISIWRQNIQNDEFGLAHEFTIKK 148 + + T+ ++ + LS P +++ G AD T+++W +++N + L H F K Sbjct: 267 NTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW--DLRNLKLKL-HSFESHK 323 Query: 149 GFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAE---------LE 199 + + S + +LA GT+ + + + LS G E+ AE Sbjct: 324 DEIFQVQWS----PHNETILASSGTDRRLHV--WDLSKIGEEQSTEDAEDGPPELLFIHG 377 Query: 200 GHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEE 246 GH + ++ E +++CS S+D +++W++ N D+ E Sbjct: 378 GHTAKISDFSWNPNEP---WIICSVSEDNIMQVWQMAENVYNDEEPE 421 >3BG0-A nrPDB Length = 316 Score = 37.0 bits (84), Expect = 0.037, Method: Compositional matrix adjust. Identities = 25/105 (23%), Positives = 50/105 (47%), Gaps = 9/105 (8%) Query: 640 NTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIK 699 N ++ + + H +W WA +GN+ + S D+ V +WR + + A Sbjct: 44 NGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAG-- 101 Query: 700 HTKAVTAI--SIHDSMIREKILISVGLENGEIYLYSYT-LGKFEL 741 H +V ++ + HD ++++ G +G I L +YT G++E+ Sbjct: 102 HDSSVNSVCWAPHD----YGLILACGSSDGAISLLTYTGEGQWEV 142 Score = 28.9 bits (63), Expect = 8.7, Method: Compositional matrix adjust. Identities = 30/125 (24%), Positives = 53/125 (42%), Gaps = 7/125 (5%) Query: 587 IRIFSTENWLEIKPA-LPFHSLTITRLKFSKD--GKFLLSVCRDRKWALWERNMEDNTFE 643 ++IF N +I A L H + ++ ++ G L S DRK +W E+ T+E Sbjct: 37 VKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWRE--ENGTWE 94 Query: 644 LRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKA 703 + H + WAP ++G + S D + + + E + V + + HT Sbjct: 95 -KSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWE-VKKINNAHTIG 152 Query: 704 VTAIS 708 A+S Sbjct: 153 CNAVS 157 Score = 28.9 bits (63), Expect = 8.8, Method: Compositional matrix adjust. Identities = 55/282 (19%), Positives = 106/282 (37%), Gaps = 48/282 (17%) Query: 53 ATLKGHEAEVTCVRFVPD--SDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVAL 110 A L+GHE V V + + + S S D V IW+ + + + + H S ++ ++ Sbjct: 51 ADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDS-SVNSV 109 Query: 111 SALPS----LISVGCADGTISIWRQNIQND----EFGLAHEFTIKKGFFYPLCLSLSKV- 161 P +++ G +DG IS+ + + AH + P + S + Sbjct: 110 CWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLID 169 Query: 162 ----EEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPG 217 ++ Y+ + I + + G + + +LE H DWV+ +A+ Sbjct: 170 HPSGQKPNYIKRFASGGCDNLIKLWKEEEDG--QWKEEQKLEAHSDWVRDVAWAPSIGLP 227 Query: 218 DYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALI 277 + S SQD + +W DD+ ++ LL +KF Sbjct: 228 TSTIASCSQDGRVFIW------TCDDASSNTWSPKLL----HKF---------------- 261 Query: 278 MGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVC 319 +D + + W + L + D + +W+ + G WVC Sbjct: 262 ---NDVVWHVSWSITANILAVSGGDNKVTLWK-ESVDGQWVC 299 >6BX3-B nrPDB Length = 412 Score = 37.0 bits (84), Expect = 0.037, Method: Compositional matrix adjust. Identities = 57/238 (23%), Positives = 91/238 (38%), Gaps = 38/238 (15%) Query: 563 CLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEI---KPALPFHSLTITRLKFSKDGK 619 CL SP +A C N + I+ + + I L H IT + +S DG+ Sbjct: 30 CLQFSPCGDYLALGC-----ANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGR 84 Query: 620 FLLSVCRDRKWALWERNMEDNTF-ELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKT 678 LL+ RD LW+ + E+RF + IW W + T + Sbjct: 85 LLLTSSRDWSIKLWDLSKPSKPLKEIRFDSP------IWGCQWLDAKRRLCVATIFEESD 138 Query: 679 VKVWRHQKEP-------ADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYL 731 V +P +D+ L ++ H V ++H + +I VG G + Sbjct: 139 AYVIDFSNDPVASLLSKSDEKQLSSTPDH-GYVLVCTVH---TKHPNIIIVGTSKGWLDF 194 Query: 732 YSY-TLGKFELITQLNEDITPADKITRLRWSHL--KRNGKLFLGVGSSDLSTRIYSLA 786 Y + +L + E I L KIT HL +NG+ L + SD + R Y ++ Sbjct: 195 YKFHSLYQTECIHSL--------KITSSNIKHLIVSQNGER-LAINCSDRTIRQYEIS 243 Score = 30.0 bits (66), Expect = 3.9, Method: Compositional matrix adjust. Identities = 14/39 (35%), Positives = 21/39 (53%) Query: 374 ICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLF 412 IC + + +T IAWSP G LL +S D + +L+ Sbjct: 60 ICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLW 98 >5WLC-LU nrPDB Length = 489 Score = 36.6 bits (83), Expect = 0.044, Method: Compositional matrix adjust. Identities = 25/79 (31%), Positives = 39/79 (49%), Gaps = 6/79 (7%) Query: 55 LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCI---QTIQHYSKTIVALS 111 K H + V V F P D +V+ S D ++I+K T++ H + I + +QH + V S Sbjct: 301 FKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYK-TNHGHSREIYHTKRMQHVFQ--VKYS 357 Query: 112 ALPSLISVGCADGTISIWR 130 I G DG + +WR Sbjct: 358 MDSKYIISGSDDGNVRLWR 376 Score = 29.6 bits (65), Expect = 5.6, Method: Compositional matrix adjust. Identities = 15/59 (25%), Positives = 33/59 (55%), Gaps = 2/59 (3%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWK 87 IV K+I ++ +++ +Y T + V V++ DS +++S S+D +V++W+ Sbjct: 320 IVTGSYDKSIRIYKTNHGHSREIYHTKRMQH--VFQVKYSMDSKYIISGSDDGNVRLWR 376 >4L9O-A nrPDB Length = 349 Score = 36.2 bits (82), Expect = 0.053, Method: Compositional matrix adjust. Identities = 19/60 (31%), Positives = 30/60 (50%), Gaps = 4/60 (6%) Query: 261 FQIDDELRVGINFEALIMGHDDWISSLQWHESRLQ---LLAATADTSLMVWEPDETSGIW 317 ++ DD + I EA GH DW+ + W SRL + A+ D ++++W D S W Sbjct: 237 WRYDDAAKTFIEEEAF-QGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKW 295 Score = 33.5 bits (75), Expect = 0.38, Method: Compositional matrix adjust. Identities = 48/220 (21%), Positives = 87/220 (39%), Gaps = 28/220 (12%) Query: 27 KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPD--SDFMVSASEDHHVK 84 +++ + KTI +++ I+ N+ + TL GHE V V + + S S D V Sbjct: 82 RRLATCSSDKTIKIFE-IDGENQRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVL 140 Query: 85 IWKFTDYSHLQCIQTIQHYSKTIVALSALP----SLISVGCADGTISIWRQNIQNDEFGL 140 IWK D + + ++ ++S P ++ +DG ISI ++ + G Sbjct: 141 IWK-EDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISI----VEFKDGGA 195 Query: 141 -------AHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCR 193 H + + P+ L + GG + V I + D + Sbjct: 196 LEPIVIQGHAIGVNAASWAPISLP-----DNTRRFVSGGCDNLVKIWRY---DDAAKTFI 247 Query: 194 VVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW 233 +GH DWV+ +A+ Y + + SQDR + +W Sbjct: 248 EEEAFQGHSDWVRDVAWSPSRLSKSY-IATASQDRTVLIW 286 Score = 31.2 bits (69), Expect = 1.9, Method: Compositional matrix adjust. Identities = 20/66 (30%), Positives = 28/66 (42%), Gaps = 3/66 (4%) Query: 616 KDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASR 675 K G L S D K +W+ EDN + H + WAP E+G V + AS Sbjct: 125 KFGVILASCSYDGKVLIWK---EDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASS 181 Query: 676 DKTVKV 681 D + + Sbjct: 182 DGKISI 187 Score = 29.3 bits (64), Expect = 7.1, Method: Compositional matrix adjust. Identities = 14/64 (21%), Positives = 31/64 (48%), Gaps = 2/64 (3%) Query: 620 FLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTV 679 ++ + +DR +W ++ + N +E + ++ + W A W+ GNV + D V Sbjct: 273 YIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVCWRASWS--LSGNVLAISGGDNKV 330 Query: 680 KVWR 683 +W+ Sbjct: 331 TLWK 334 >5Y88-O nrPDB Length = 451 Score = 36.2 bits (82), Expect = 0.061, Method: Compositional matrix adjust. Identities = 25/94 (26%), Positives = 42/94 (44%), Gaps = 6/94 (6%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 I G I LWD + TL GH+ + V+ P +VS+S D V++W Sbjct: 239 IATAGRDSVIKLWDM---RTRIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLW-- 293 Query: 89 TDYSHLQCIQTIQHYSKTIVALSALPSLISVGCA 122 D + ++ + H+ +++ A + P SV A Sbjct: 294 -DVVAGKTMKVLTHHKRSVRATALHPKEFSVASA 326 Score = 30.8 bits (68), Expect = 2.4, Method: Compositional matrix adjust. Identities = 73/314 (23%), Positives = 116/314 (36%), Gaps = 80/314 (25%) Query: 37 TIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSD---FMVSASEDHHVKIWKFTD--- 90 T+ +WD K TL GH V VR V SD ++ S SED VK W Sbjct: 163 TMKVWDLATGKLK---TTLAGH---VMTVRDVAVSDRHPYLFSVSEDKTVKCWDLEKNQI 216 Query: 91 ----YSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGL-AHEFT 145 Y HL ++T V++ LI+ D I +W + L H+ Sbjct: 217 IRDYYGHLSGVRT--------VSIHPTLDLIATAGRDSVIKLWDMRTRIPVITLVGHKGP 268 Query: 146 IKKGFFYPL---CLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHE 202 I + P+ +S S + + G + V L H+ Sbjct: 269 INQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMKV--------------------LTHHK 308 Query: 203 DWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSE-EDSKKLTLLSNKQYKF 261 V++ A P ++ + S D IR W + L+ + E E + + LS Q Sbjct: 309 RSVRATALH----PKEFSVASACTDD-IRSWGLAEGSLLTNFESEKTGIINTLSINQ--- 360 Query: 262 QIDDELRVG-----INFEALIMGHD-------DWISSLQ---------WHESRLQLLAAT 300 DD L G ++F GH + + SL+ + ++ L+L+ Sbjct: 361 --DDVLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEGERSVLCSTFDKTGLRLITGE 418 Query: 301 ADTSLMVWEPDETS 314 AD S+ +W+ DET+ Sbjct: 419 ADKSIKIWKQDETA 432 Score = 30.0 bits (66), Expect = 4.1, Method: Compositional matrix adjust. Identities = 27/116 (23%), Positives = 46/116 (39%), Gaps = 10/116 (8%) Query: 16 KQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMV 75 + VSD H + + KT+ WD +E N + GH + V V P D + Sbjct: 186 RDVAVSDRHPY--LFSVSEDKTVKCWD-LEKNQ--IIRDYYGHLSGVRTVSIHPTLDLIA 240 Query: 76 SASEDHHVKIWKFTDYSHLQCIQTIQHYS--KTIVALSALPSLISVGCADGTISIW 129 +A D +K+W + + I + H + P ++S D T+ +W Sbjct: 241 TAGRDSVIKLWDM--RTRIPVITLVGHKGPINQVQCTPVDPQVVS-SSTDATVRLW 293 >5Y1U-A nrPDB Length = 456 Score = 35.8 bits (81), Expect = 0.067, Method: Compositional matrix adjust. Identities = 51/227 (22%), Positives = 96/227 (42%), Gaps = 25/227 (11%) Query: 37 TIALWD----PIEPNNKGVYATLKGHEAEVTCVRF-VPDSDFMVSASEDHHVKIWKFTDY 91 TI LWD P E GH A V V + + S ++D + IW Sbjct: 232 TICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSN 291 Query: 92 SHLQCIQTIQHYSKTIVALSALPS---LISVGCADGTISIWRQNIQNDEFGLAHEFTIKK 148 + + ++ ++ + LS P +++ G AD T+++W +++N + L H F K Sbjct: 292 NTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW--DLRNLKLKL-HSFESHK 348 Query: 149 GFFYPLCLSLSKVEEKKYLLAIGGTN--VNVFIASFILSDSGIEKCR-----VVAELEGH 201 + + S + +LA GT+ +NV+ S I + E ++ GH Sbjct: 349 DEIFQVQWS----PHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGH 404 Query: 202 EDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDS 248 + ++ E +++CS S+D +++W++ N D+ E S Sbjct: 405 TAKISDFSWNPNEP---WVICSVSEDNIMQVWQMAENIYNDEDPEGS 448 Score = 29.3 bits (64), Expect = 6.7, Method: Compositional matrix adjust. Identities = 32/127 (25%), Positives = 57/127 (44%), Gaps = 20/127 (15%) Query: 29 IVAFG-AGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSD-FMVSASEDHHVKIW 86 I+A G A KT+ALWD N K + + H+ E+ V++ P ++ + S+ D + +W Sbjct: 319 ILATGSADKTVALWD--LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW 376 Query: 87 KFTDYSHLQCIQTIQH-----------YSKTIVALSALPSLISVGCA---DGTISIWR-- 130 + Q + + ++ I S P+ V C+ D + +W+ Sbjct: 377 DLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 436 Query: 131 QNIQNDE 137 +NI NDE Sbjct: 437 ENIYNDE 443 >6G51-g nrPDB Length = 317 Score = 35.8 bits (81), Expect = 0.074, Method: Compositional matrix adjust. Identities = 44/194 (22%), Positives = 79/194 (40%), Gaps = 34/194 (17%) Query: 53 ATLKGHEAEVTCVRFVPD-SDFMVSASEDHHVKIWKF----TDYSHLQ-CIQTIQHYSKT 106 TLKGH VT + P D ++SAS D + +WK T+Y Q ++ H+ Sbjct: 9 GTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSD 68 Query: 107 IVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKY 166 +V +S+ G DGT+ +W T + F V K Sbjct: 69 VV-ISSDGQFALSGSWDGTLRLWDLTTG----------TTTRRF----------VGHTKD 107 Query: 167 LLAIGGTNVNVFIAS-----FILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLL 221 +L++ ++ N I S I + + C+ + E H +WV + F + + ++ Sbjct: 108 VLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSS--NPII 165 Query: 222 CSGSQDRYIRLWRI 235 S D+ +++W + Sbjct: 166 VSCGWDKLVKVWNL 179 Score = 33.5 bits (75), Expect = 0.37, Method: Compositional matrix adjust. Identities = 48/219 (21%), Positives = 90/219 (41%), Gaps = 39/219 (17%) Query: 37 TIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIW------KFT- 89 T+ LWD + GH +V V F D+ +VS S D +K+W K+T Sbjct: 86 TLRLWDLTTGTTTRRFV---GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTV 142 Query: 90 -DYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKK 148 D SH + + ++ S+ P ++S G D + +W N+ N + H Sbjct: 143 QDESHSEWVSCVRFSPN-----SSNPIIVSCG-WDKLVKVW--NLANCKLKTNH------ 188 Query: 149 GFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSL 208 + L+ V L A GG + + + + + + L+G D + +L Sbjct: 189 -IGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD-------LNEGKHLYTLDG-GDIINAL 239 Query: 209 AFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEED 247 F +P Y LC+ + I++W + ++D+ +++ Sbjct: 240 CF----SPNRYWLCAATGPS-IKIWDLEGKIIVDELKQE 273 Score = 33.1 bits (74), Expect = 0.44, Method: Compositional matrix adjust. Identities = 53/243 (21%), Positives = 97/243 (39%), Gaps = 30/243 (12%) Query: 1 MVECITPEAIFIGANK-QTQVSDIHKVKK-IVAFGAGKTIALWDPI-EPNNKGV-YATLK 56 M E +T G N TQ++ + I++ KTI +W + N G+ L+ Sbjct: 1 MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR 60 Query: 57 GHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTI-VALSALPS 115 GH V+ V D F +S S D +++W T + + + + H + VA S+ Sbjct: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTR--RFVGHTKDVLSVAFSSDNR 118 Query: 116 LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFF--YPLCLSLSKVEEKKYLLAIGGT 173 I G D TI +W + G+ ++T++ + C+ S +++ G Sbjct: 119 QIVSGSRDKTIKLW------NTLGVC-KYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWD 171 Query: 174 N-VNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRL 232 V V+ + C++ GH ++ ++ +P L SG +D L Sbjct: 172 KLVKVW---------NLANCKLKTNHIGHTGYLNTVTV----SPDGSLCASGGKDGQAML 218 Query: 233 WRI 235 W + Sbjct: 219 WDL 221 Score = 33.1 bits (74), Expect = 0.51, Method: Compositional matrix adjust. Identities = 37/131 (28%), Positives = 60/131 (45%), Gaps = 11/131 (8%) Query: 554 LYGHGFEITCLDISPD-QKLIASACRSNNVQNAVIRIFSTE-NWLEIKPALPFHSLTITR 611 L GH +T + +P +I SA R + + ++ E N+ + AL HS ++ Sbjct: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTI--IMWKLTRDETNYGIPQRALRGHSHFVSD 68 Query: 612 LKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFV 671 + S DG+F LS D LW+ + T RF HT+ + ++ V Sbjct: 69 VVISSDGQFALSGSWDGTLRLWD--LTTGTTTRRFVG---HTKDVLSVAFS--SDNRQIV 121 Query: 672 TASRDKTVKVW 682 + SRDKT+K+W Sbjct: 122 SGSRDKTIKLW 132 >4U1E-I nrPDB Length = 347 Score = 35.8 bits (81), Expect = 0.075, Method: Compositional matrix adjust. Identities = 25/82 (30%), Positives = 37/82 (45%), Gaps = 9/82 (10%) Query: 602 LPFHSLTITRLKFSKDGKFLLSVCRDRKWALW-ERNMEDNTFELRFKNEKPHTRIIWDAD 660 L H +T++K++K+G L S +D ++W N E R HT IW D Sbjct: 6 LTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGE------RLGTLDGHTGTIWSID 59 Query: 661 WAPLEFGNVFVTASRDKTVKVW 682 F VT S D ++K+W Sbjct: 60 VDC--FTKYCVTGSADYSIKLW 79 Score = 31.2 bits (69), Expect = 1.8, Method: Compositional matrix adjust. Identities = 21/78 (26%), Positives = 38/78 (48%), Gaps = 7/78 (8%) Query: 55 LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYS-HLQCIQTIQHYSKTI--VALS 111 L GHE +T V++ + D + S S+D +W YS + + + T+ ++ TI + + Sbjct: 6 LTGHERPLTQVKYNKEGDLLFSCSKDSSASVW----YSLNGERLGTLDGHTGTIWSIDVD 61 Query: 112 ALPSLISVGCADGTISIW 129 G AD +I +W Sbjct: 62 CFTKYCVTGSADYSIKLW 79 >6BX3-A nrPDB Length = 314 Score = 35.8 bits (81), Expect = 0.083, Method: Compositional matrix adjust. Identities = 39/184 (21%), Positives = 76/184 (41%), Gaps = 27/184 (14%) Query: 557 HGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSK 616 +G + TC ISPD + +A Q I I+ + + H+ + L +S Sbjct: 11 NGLKATCAKISPDGQFLAIT------QGLNILIYDINRRTVSQTLVTSHARPFSELCWSP 64 Query: 617 DGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEF---GNVFVTA 673 DG+ + + D + + HT I A L F GN+ T+ Sbjct: 65 DGQCIATASDDFSVEI-----------IHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTS 113 Query: 674 SRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYS 733 S D+++K+W + + +++ H++AV ++ D + + ++S G +G I ++ Sbjct: 114 SMDESIKIW----DTLNGSLMKTISAHSEAVVSV---DVPMNDSSILSSGSYDGLIRIFD 166 Query: 734 YTLG 737 G Sbjct: 167 AETG 170 Score = 34.7 bits (78), Expect = 0.17, Method: Compositional matrix adjust. Identities = 24/83 (28%), Positives = 42/83 (50%), Gaps = 6/83 (7%) Query: 50 GVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVA 109 G+ T GH A V + F + + ++S D +KIW + S + +TI +S+ +V+ Sbjct: 86 GLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLM---KTISAHSEAVVS 142 Query: 110 LSAL---PSLISVGCADGTISIW 129 + S++S G DG I I+ Sbjct: 143 VDVPMNDSSILSSGSYDGLIRIF 165 >5CXC-A nrPDB Length = 510 Score = 35.4 bits (80), Expect = 0.092, Method: Compositional matrix adjust. Identities = 23/79 (29%), Positives = 36/79 (45%), Gaps = 7/79 (8%) Query: 57 GHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHL--QCIQTIQHYSKTI----VAL 110 GH A + +F+ SD + SA D V++WK+T+ H + T++ Y T + + Sbjct: 190 GHTASIKAAKFL-TSDRLASAGMDRTVRVWKYTESDHFTGELKPTLELYGHTGSVDWLDV 248 Query: 111 SALPSLISVGCADGTISIW 129 I ADG I W Sbjct: 249 DGHSKHILTASADGAIGFW 267 >4V6W-Ag nrPDB Length = 318 Score = 35.4 bits (80), Expect = 0.099, Method: Compositional matrix adjust. Identities = 42/190 (22%), Positives = 83/190 (43%), Gaps = 25/190 (13%) Query: 53 ATLKGHEAEVTCVRFVP-DSDFMVSASEDHHVKIWKF-----TDYSHLQCIQTIQHYSKT 106 TL GH VT + P D D ++SAS D + +WK T+Y + Q + + Sbjct: 9 GTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFIS 68 Query: 107 IVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPL-CLSLSKVEEKK 165 V LS+ + G D T+ +W LA T ++ + LS++ + + Sbjct: 69 DVVLSSDGNYALSGSWDQTLRLW---------DLAAGKTTRRFEGHTKDVLSVAFSADNR 119 Query: 166 YLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGS 225 +++ G + + + + + +C+ + +GH DWV + F + + ++ S Sbjct: 120 QIVS-GSRDKTIKLWNT------LAECKFTIQEDGHTDWVSCVRFSPNHS--NPIIVSCG 170 Query: 226 QDRYIRLWRI 235 DR +++W + Sbjct: 171 WDRTVKVWNL 180 Score = 33.5 bits (75), Expect = 0.39, Method: Compositional matrix adjust. Identities = 34/133 (25%), Positives = 56/133 (42%), Gaps = 14/133 (10%) Query: 552 EKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITR 611 ++LYGH I+ + +S D S ++ + T E H+ + Sbjct: 58 KRLYGHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFE------GHTKDVLS 111 Query: 612 LKFSKDGKFLLSVCRDRKWALWERNMEDNTF-ELRFK-NEKPHTRIIWDADWAPLEFGNV 669 + FS D + ++S RD+ LW NT E +F E HT + ++P + Sbjct: 112 VAFSADNRQIVSGSRDKTIKLW------NTLAECKFTIQEDGHTDWVSCVRFSPNHSNPI 165 Query: 670 FVTASRDKTVKVW 682 V+ D+TVKVW Sbjct: 166 IVSCGWDRTVKVW 178 Score = 32.3 bits (72), Expect = 0.90, Method: Compositional matrix adjust. Identities = 38/136 (27%), Positives = 56/136 (41%), Gaps = 10/136 (7%) Query: 554 LYGHGFEITCLDISP-DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRL 612 L GH +T + +P D I SA R + + N+ + L HS I+ + Sbjct: 11 LIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDV 70 Query: 613 KFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNE-KPHTRIIWDADWAPLEFGNVFV 671 S DG + LS D+ LW+ T RF+ K + + AD V Sbjct: 71 VLSSDGNYALSGSWDQTLRLWDLAAGKTT--RRFEGHTKDVLSVAFSAD------NRQIV 122 Query: 672 TASRDKTVKVWRHQKE 687 + SRDKT+K+W E Sbjct: 123 SGSRDKTIKLWNTLAE 138 Score = 32.0 bits (71), Expect = 0.94, Method: Compositional matrix adjust. Identities = 50/194 (25%), Positives = 79/194 (40%), Gaps = 36/194 (18%) Query: 36 KTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQ 95 +T+ LWD + +GH +V V F D+ +VS S D +K+W + + Sbjct: 86 QTLRLWDLAAGKTTRRF---EGHTKDVLSVAFSADNRQIVSGSRDKTIKLWN----TLAE 138 Query: 96 CIQTIQHYSKT----IVALS---ALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKK 148 C TIQ T V S + P ++S G D T+ +W N+ N + H Sbjct: 139 CKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCG-WDRTVKVW--NLANCKLKNNHHG--HN 193 Query: 149 GFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSL 208 G+ L+ V L GG + + + L+D + + LE H D + +L Sbjct: 194 GY-----LNTVTVSPDGSLCTSGGKDSKALL--WDLNDG-----KNLYTLE-HNDIINAL 240 Query: 209 AFRHQETPGDYLLC 222 F +P Y LC Sbjct: 241 CF----SPNRYWLC 250 Score = 32.0 bits (71), Expect = 1.0, Method: Compositional matrix adjust. Identities = 37/148 (25%), Positives = 57/148 (38%), Gaps = 9/148 (6%) Query: 24 HKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHV 83 H IV+ G +T+ +W+ K + GH + V PD S +D Sbjct: 161 HSNPIIVSCGWDRTVKVWNLANCKLKNNH---HGHNGYLNTVTVSPDGSLCTSGGKDSKA 217 Query: 84 KIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADG-TISIWRQNIQNDEFGLAH 142 +W D +L T++H + I AL P+ + A G +I IW + L Sbjct: 218 LLWDLNDGKNL---YTLEH-NDIINALCFSPNRYWLCVAYGPSIKIWDLACKKTVEELRP 273 Query: 143 EFTIKKGFF-YPLCLSLSKVEEKKYLLA 169 E P CLSL+ + + L A Sbjct: 274 EVVSPTSKADQPQCLSLAWSTDGQTLFA 301 Score = 29.6 bits (65), Expect = 4.8, Method: Compositional matrix adjust. Identities = 23/84 (27%), Positives = 38/84 (45%), Gaps = 13/84 (15%) Query: 381 ISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGY 440 + G + ++D+ S G Y L+ S DQT RL+ ++A R + H Sbjct: 60 LYGHSHFISDVVLSSDGNYALSGSWDQTLRLW------------DLAAGKTTRRFEGHTK 107 Query: 441 DMICVETVTDTR-FVSGGDEKILR 463 D++ V D R VSG +K ++ Sbjct: 108 DVLSVAFSADNRQIVSGSRDKTIK 131 >5A9Q-7 nrPDB Length = 360 Score = 35.4 bits (80), Expect = 0.10, Method: Compositional matrix adjust. Identities = 21/78 (26%), Positives = 36/78 (46%), Gaps = 2/78 (2%) Query: 605 HSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPL 664 H I + F G+ + + D+ +W+++ E + + K H+ +W WA Sbjct: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKS-ESGDWHCT-ASWKTHSGSVWRVTWAHP 68 Query: 665 EFGNVFVTASRDKTVKVW 682 EFG V + S D+T VW Sbjct: 69 EFGQVLASCSFDRTAAVW 86 >3F3P-A nrPDB Length = 351 Score = 35.4 bits (80), Expect = 0.11, Method: Compositional matrix adjust. Identities = 19/65 (29%), Positives = 36/65 (55%), Gaps = 1/65 (1%) Query: 618 GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDK 677 G+ + + D+ +++ + + + +EL + + H I DWA E+G + +AS DK Sbjct: 23 GRHVATCSSDQHIKVFKLDKDTSNWELS-DSWRAHDSSIVAIDWASPEYGRIIASASYDK 81 Query: 678 TVKVW 682 TVK+W Sbjct: 82 TVKLW 86 >3CFV-B nrPDB Length = 414 Score = 34.7 bits (78), Expect = 0.16, Method: Compositional matrix adjust. Identities = 48/217 (22%), Positives = 92/217 (42%), Gaps = 25/217 (11%) Query: 37 TIALWD----PIEPNNKGVYATLKGHEAEVTCVRF-VPDSDFMVSASEDHHVKIWKFTDY 91 T+ LWD P E A GH A V V + + S ++D + IW Sbjct: 203 TVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSN 262 Query: 92 SHLQCIQTIQHYSKTIVALSALPS---LISVGCADGTISIWRQNIQNDEFGLAHEFTIKK 148 + + + ++ + LS P +++ G AD T+++W +++N + L H F K Sbjct: 263 TTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALW--DLRNLKLKL-HTFESHK 319 Query: 149 GFFYPLCLSLSKVEEKKYLLAIGGTN--VNVFIASFILSDSGIEKCR-----VVAELEGH 201 + + S + +LA GT+ +NV+ S I + E ++ GH Sbjct: 320 DEIFQVHWS----PHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGH 375 Query: 202 EDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRIN 238 + ++ E +++CS S+D +++W++ N Sbjct: 376 TAKISDFSWNPNEP---WVICSVSEDNIMQIWQMAEN 409 Score = 30.4 bits (67), Expect = 2.9, Method: Compositional matrix adjust. Identities = 30/133 (22%), Positives = 59/133 (44%), Gaps = 12/133 (9%) Query: 5 ITPEAIFIGANKQTQVSDIHKVKKIVAFGA---GKTIALWDPIEPNNKGVYATLKGHEAE 61 + +AIF G + + H + + + FG+ + + +WD + H AE Sbjct: 219 VDAKAIFTGHSAVVEDVAWHLLHESL-FGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAE 277 Query: 62 VTCVRFVPDSDF-MVSASEDHHVKIWKFTDYSHLQC-IQTIQHYSKTIVALSALPSLISV 119 V C+ F P S+F + + S D V +W D +L+ + T + + I + P ++ Sbjct: 278 VNCLSFNPYSEFILATGSADKTVALW---DLRNLKLKLHTFESHKDEIFQVHWSPHNETI 334 Query: 120 GCADGT---ISIW 129 + GT +++W Sbjct: 335 LASSGTDRRLNVW 347 >5WLC-SG nrPDB Length = 573 Score = 34.7 bits (78), Expect = 0.17, Method: Compositional matrix adjust. Identities = 26/115 (22%), Positives = 46/115 (40%), Gaps = 7/115 (6%) Query: 20 VSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYA-TLKGHEAEVTCVRFVPDSDFMVSAS 78 ++D K K + + G + P +K Y T +GH E+ V PD ++V+ Sbjct: 201 ITDFSKRPKKLKYAKGGAKYI-----PTSKHEYENTTEGHYDEILTVAASPDGKYVVTGG 255 Query: 79 EDHHVKIWKFTDYSHLQCIQTIQHYSKTI-VALSALPSLISVGCADGTISIWRQN 132 D + +W S ++ I T + + +A + CAD I + N Sbjct: 256 RDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRKNSDQLYASCADFKIRTYSIN 310 Score = 32.7 bits (73), Expect = 0.69, Method: Compositional matrix adjust. Identities = 26/92 (28%), Positives = 43/92 (46%), Gaps = 7/92 (7%) Query: 341 FWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLG-ISGATKDVTDIAWSPSG-- 397 FW + + F++ +GS ++W DN+ + LG +SGA VT I SG Sbjct: 473 FWITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVESGKH 532 Query: 398 ---EYLLATSLDQTTRLFAPWIYDASGRKREI 426 ++ + S+ + RL WI + SG + I Sbjct: 533 GKEKFRILASIAKEHRL-GRWIANVSGARNGI 563 >6ELZ-p nrPDB Length = 460 Score = 34.3 bits (77), Expect = 0.23, Method: Compositional matrix adjust. Identities = 52/218 (23%), Positives = 91/218 (41%), Gaps = 47/218 (21%) Query: 53 ATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALS- 111 A L+GH+A V + V D+ ++SAS D+ + W T Y + + ++ + +S Sbjct: 202 AILEGHKAPVVSID-VSDNSRILSASYDNSIGFWS-TIYKEMTVVDPLEDINNPNNKIST 259 Query: 112 ALPSLISVGCADGTIS------------------IWRQNIQNDEFGLAHEFTIK------ 147 A + DGTI I+ + ++ + TIK Sbjct: 260 AARKRRKLTMKDGTIRRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVT 319 Query: 148 ------KGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAE--LE 199 + Y L LS++++ LLA G + ++ L D + V + L Sbjct: 320 ARCIDTRTTSYSL-LSIAQLSTLN-LLACGSSARHI-----TLHDPRVGASSKVTQQQLI 372 Query: 200 GHEDWVKSLAFRHQETP-GDYLLCSGSQDRYIRLWRIR 236 GH+++V SL P +Y+LCSGS D +++W +R Sbjct: 373 GHKNFVSSL----DTCPENEYILCSGSHDGTVKVWDVR 406 >6HHQ-h nrPDB Length = 319 Score = 34.3 bits (77), Expect = 0.24, Method: Compositional matrix adjust. Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 3/88 (3%) Query: 596 LEIKPALPFHSLTITRLKFSK-DGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTR 654 L ++ L H+ +T L S LLS RD+ W+ +D F + ++ K H+ Sbjct: 7 LVLRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSH 66 Query: 655 IIWDADWAPLEFGNVFVTASRDKTVKVW 682 I+ D G ++AS DKT+++W Sbjct: 67 IVQDC--TLTADGAYALSASWDKTLRLW 92 Score = 33.9 bits (76), Expect = 0.27, Method: Compositional matrix adjust. Identities = 25/106 (23%), Positives = 44/106 (41%), Gaps = 17/106 (16%) Query: 36 KTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQ 95 KT+ LWD Y GH+++V V + ++S S D +K+W Q Sbjct: 87 KTLRLWDVATGE---TYQRFVGHKSDVMSVDIDKKASMIISGSRDKTIKVWTIKG----Q 139 Query: 96 CIQTIQHYSKTIVALSALP---------SLISVGCADGTISIWRQN 132 C+ T+ ++ + + +P ++IS G D + W N Sbjct: 140 CLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGN-DKMVKAWNLN 184 Score = 32.7 bits (73), Expect = 0.59, Method: Compositional matrix adjust. Identities = 34/130 (26%), Positives = 59/130 (45%), Gaps = 9/130 (6%) Query: 554 LYGHGFEITCLDISPDQ-KLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRL 612 L GH +T L S Q L+ SA R + + + + + ++ + HS + Sbjct: 13 LEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVR-SFKGHSHIVQDC 71 Query: 613 KFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVT 672 + DG + LS D+ LW+ + T++ RF K + D D + ++ ++ Sbjct: 72 TLTADGAYALSASWDKTLRLWDVATGE-TYQ-RFVGHKSDVMSV-DID----KKASMIIS 124 Query: 673 ASRDKTVKVW 682 SRDKT+KVW Sbjct: 125 GSRDKTIKVW 134 Score = 31.6 bits (70), Expect = 1.3, Method: Compositional matrix adjust. Identities = 38/183 (20%), Positives = 69/183 (37%), Gaps = 18/183 (9%) Query: 54 TLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTI-VALSA 112 + KGH V D + +SAS D +++W Q + + H S + V + Sbjct: 60 SFKGHSHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQ--RFVGHKSDVMSVDIDK 117 Query: 113 LPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGG 172 S+I G D TI +W Q L H + + P K ++ + G Sbjct: 118 KASMIISGSRDKTIKVWTIKGQCLATLLGHNDWVSQVRVVP----NEKADDDSVTIISAG 173 Query: 173 TNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRL 232 + ++ + + ++ A+ GH + +L +P L+ S +D I L Sbjct: 174 NDK-------MVKAWNLNQFQIEADFIGHNSNINTLT----ASPDGTLIASAGKDGEIML 222 Query: 233 WRI 235 W + Sbjct: 223 WNL 225 Score = 29.3 bits (64), Expect = 6.7, Method: Compositional matrix adjust. Identities = 16/42 (38%), Positives = 23/42 (54%), Gaps = 3/42 (7%) Query: 198 LEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRIND 239 LEGH WV SLA + LL S S+D+ + W++ +D Sbjct: 13 LEGHNGWVTSLATSAGQPN---LLLSASRDKTLISWKLTGDD 51 Score = 28.9 bits (63), Expect = 7.9, Method: Compositional matrix adjust. Identities = 14/60 (23%), Positives = 26/60 (43%), Gaps = 3/60 (5%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 I++ G K + W+ N + A GH + + + PD + SA +D + +W Sbjct: 169 IISAGNDKMVKAWNL---NQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNL 225 >4J0X-A nrPDB Length = 451 Score = 33.9 bits (76), Expect = 0.26, Method: Compositional matrix adjust. Identities = 26/115 (22%), Positives = 46/115 (40%), Gaps = 7/115 (6%) Query: 20 VSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYA-TLKGHEAEVTCVRFVPDSDFMVSAS 78 ++D K K + + G + P +K Y T +GH E+ V PD ++V+ Sbjct: 79 ITDFSKRPKKLKYAKGGAKYI-----PTSKHEYENTTEGHYDEILTVAASPDGKYVVTGG 133 Query: 79 EDHHVKIWKFTDYSHLQCIQTIQHYSKTI-VALSALPSLISVGCADGTISIWRQN 132 D + +W S ++ I T + + +A + CAD I + N Sbjct: 134 RDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRKNSDQLYASCADFKIRTYSIN 188 Score = 33.1 bits (74), Expect = 0.51, Method: Compositional matrix adjust. Identities = 26/92 (28%), Positives = 43/92 (46%), Gaps = 7/92 (7%) Query: 341 FWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLG-ISGATKDVTDIAWSPSG-- 397 FW + + F++ +GS ++W DN+ + LG +SGA VT I SG Sbjct: 351 FWITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVESGKH 410 Query: 398 ---EYLLATSLDQTTRLFAPWIYDASGRKREI 426 ++ + S+ + RL WI + SG + I Sbjct: 411 GKEKFRILASIAKEHRL-GRWIANVSGARNGI 441 >5OQL-X nrPDB Length = 630 Score = 33.5 bits (75), Expect = 0.35, Method: Compositional matrix adjust. Identities = 25/106 (23%), Positives = 49/106 (46%), Gaps = 8/106 (7%) Query: 27 KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIW 86 K +V GA K + +++ + + H VT + F ++ + S S+D VK+W Sbjct: 259 KFVVTGGADKRLVVYNAADLKPIKAFTQ---HRDAVTGLAFRRGTNQLYSCSKDRTVKVW 315 Query: 87 KFTDYSHLQCIQTIQHYSKTIVALSAL--PSLISVGCADGTISIWR 130 + ++ ++T+ + I+ + AL +SVG D T W+ Sbjct: 316 SLDELAY---VETLFGHQDEILDIDALGQERCVSVGARDRTARYWK 358 >5BJS-A nrPDB Length = 605 Score = 33.5 bits (75), Expect = 0.36, Method: Compositional matrix adjust. Identities = 39/154 (25%), Positives = 64/154 (41%), Gaps = 22/154 (14%) Query: 554 LYGHGFEITCLDISP-DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPF-----HSL 607 L GHG I L SP + +IASA + IRI+S E +P + HS Sbjct: 174 LVGHGGGINDLATSPANPYIIASAS-----DDTTIRIWSLAPEHEKQPCVCILGGEGHSY 228 Query: 608 TITRLKFSKDGKFLLSVCRDRK---WALWERNMEDNTFEL-----RFKNEKPHTRIIWDA 659 + + F +G+++LS D+ WAL E E + F + + H ++ Sbjct: 229 DLLSVAFHDNGRYVLSAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLV--- 285 Query: 660 DWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYV 693 D + A + T+ +WR + +DD + Sbjct: 286 DCVAFYGDLILSRACHEDTIVLWRIEGFSSDDPI 319 Score = 30.8 bits (68), Expect = 2.1, Method: Compositional matrix adjust. Identities = 28/119 (23%), Positives = 55/119 (46%), Gaps = 23/119 (19%) Query: 359 GKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYD 418 G G+ +++ + + +G G + D+A SP+ Y++A++ D TT Sbjct: 155 GNEGNVKVYNVTEGKLYRTLVGHGGG---INDLATSPANPYIIASASDDTTI-------- 203 Query: 419 ASGRKREIATWHEFSRPQI-------HGYDMICVETVTDTRFV-SGGDEKILRSFDLPK 469 R +A HE +P + H YD++ V + R+V S G ++++ + LP+ Sbjct: 204 ---RIWSLAPEHE-KQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPE 258 Score = 30.0 bits (66), Expect = 4.2, Method: Compositional matrix adjust. Identities = 22/88 (25%), Positives = 37/88 (42%), Gaps = 1/88 (1%) Query: 364 WRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFA-PWIYDASGR 422 W + + C LG G + D+ +A+ +G Y+L+ DQ L+A P + Sbjct: 206 WSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPEFPNEHME 265 Query: 423 KREIATWHEFSRPQIHGYDMICVETVTD 450 + + FS +IH + CV D Sbjct: 266 IPIVIYYPHFSSSEIHNNLVDCVAFYGD 293 >6CHG-A nrPDB Length = 312 Score = 32.3 bits (72), Expect = 0.72, Method: Compositional matrix adjust. Identities = 25/81 (30%), Positives = 37/81 (45%), Gaps = 17/81 (20%) Query: 566 ISPDQKLIASACRSNNVQNAVIRIFSTE------------NWLEIKPALPFHSLTITRLK 613 +S D S+ S+ + +IRIF TE +W+ +P I+ +K Sbjct: 141 VSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWIAEDGVVP-----ISTVK 195 Query: 614 FSKDGKFLLSVCRDRKWALWE 634 FS++GKFLL D LWE Sbjct: 196 FSRNGKFLLVKSLDNVVKLWE 216 Score = 32.0 bits (71), Expect = 1.1, Method: Compositional matrix adjust. Identities = 52/218 (23%), Positives = 86/218 (39%), Gaps = 38/218 (17%) Query: 562 TCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFL 621 T ISPD +LIA C++ ++ ++ S+ +++ H I L +S D K + Sbjct: 17 TSCQISPDGELIA-ICQNTDM---LVYEISSSKMMKLTTT---HKECINCLCWSPDSKCI 69 Query: 622 LSVCRDRKWALWERNMEDNTFEL------RFKNEKPHTRIIWDADWAPLEFGNVFVTASR 675 S ED T E+ R + HT + + GN+ ++S Sbjct: 70 AS------------GSEDFTVEITHIIYGRIRRLMGHTAPVISICYN--NKGNILCSSSM 115 Query: 676 DKTVKVWRHQKEPADDYVLEASIKHTKAVTAISI--HDSMIREKILISVGLENGEIYLYS 733 D+++K W A L+ H+ AV +I I DS I +S G +G I ++ Sbjct: 116 DESIKEWHVLSGTA----LKTMSAHSDAVVSIDIPKFDSSI-----LSSGSYDGLIRIFD 166 Query: 734 YTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFL 771 G ++D D + + RNGK L Sbjct: 167 TESGHCLKTLTYDKDWIAEDGVVPISTVKFSRNGKFLL 204 Score = 29.3 bits (64), Expect = 7.2, Method: Compositional matrix adjust. Identities = 22/79 (27%), Positives = 39/79 (49%), Gaps = 8/79 (10%) Query: 55 LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP 114 L GH A V + + + + S+S D +K W + L +T+ +S +V++ +P Sbjct: 91 LMGHTAPVISICYNNKGNILCSSSMDESIKEWHVLSGTAL---KTMSAHSDAVVSID-IP 146 Query: 115 ----SLISVGCADGTISIW 129 S++S G DG I I+ Sbjct: 147 KFDSSILSSGSYDGLIRIF 165 >4A11-B nrPDB Length = 408 Score = 32.3 bits (72), Expect = 0.88, Method: Compositional matrix adjust. Identities = 51/225 (22%), Positives = 93/225 (41%), Gaps = 19/225 (8%) Query: 163 EKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAEL-EGHEDWVKSLAFRHQETPGDY-L 220 E +Y+L+ G V V S C+ V + H D + Q P D + Sbjct: 55 EGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGM 114 Query: 221 LCSGSQDRYIRLW---RIRINDLIDDSEE-DSKKLTLLSNKQY---------KFQIDDEL 267 S S D+ +++W ++ D+ + E S ++ +S K K Q+ D L Sbjct: 115 FTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCD-L 173 Query: 268 RVGINFEALIMGHDDWISSLQWHESRLQLLA-ATADTSLMVWEPDETSGIWVCSLRLGEM 326 + G + ++ GH I ++ W +LA A+AD+ + +W+ SG + + Sbjct: 174 KSG-SCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGK 232 Query: 327 SSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKD 371 S+ +A + G + L FT + + LT G R+W + + Sbjct: 233 KSQAVESANTAHNGKVNGLCFTSDGL-HLLTVGTDNRMRLWNSSN 276 Score = 29.3 bits (64), Expect = 6.6, Method: Compositional matrix adjust. Identities = 37/173 (21%), Positives = 64/173 (36%), Gaps = 27/173 (15%) Query: 158 LSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPG 217 +S V K L+A+G V L D C + L+GH + ++++ + Sbjct: 149 MSPVSTKHCLVAVGTRGPKV-----QLCDLKSGSCSHI--LQGHRQEILAVSWSPRY--- 198 Query: 218 DYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALI 277 DY+L + S D ++LW +R +TL + K Q E+ Sbjct: 199 DYILATASADSRVKLWDVR--------RASGCLITLDQHNGKKSQA---------VESAN 241 Query: 278 MGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKG 330 H+ ++ L + L LL D + +W V ++ S KG Sbjct: 242 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKG 294 >1NR0-A nrPDB Length = 611 Score = 32.3 bits (72), Expect = 0.90, Method: Compositional matrix adjust. Identities = 32/136 (23%), Positives = 54/136 (39%), Gaps = 15/136 (11%) Query: 553 KLYGHGFEITCLDISPDQKL-IASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITR 611 L G + +D P + I S N V IF + + K H+ + Sbjct: 142 NLTGQARAMNSVDFKPSRPFRIISGSDDNTVA-----IFEGPPF-KFKSTFGEHTKFVHS 195 Query: 612 LKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEK----PHTRIIWDADWAPLEFG 667 ++++ DG S D L+ N D T F+++ H+ ++ W+P G Sbjct: 196 VRYNPDGSLFASTGGDGTIVLY--NGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPD--G 251 Query: 668 NVFVTASRDKTVKVWR 683 +AS DKT+K+W Sbjct: 252 TKIASASADKTIKIWN 267 Score = 30.4 bits (67), Expect = 2.8, Method: Compositional matrix adjust. Identities = 19/59 (32%), Positives = 29/59 (49%), Gaps = 4/59 (6%) Query: 33 GAGKTIALWDPIEPNNKGVYA--TLK--GHEAEVTCVRFVPDSDFMVSASEDHHVKIWK 87 G TI L++ ++ GV+ +LK H V + + PD + SAS D +KIW Sbjct: 209 GGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWN 267 >1NJ2-A nrPDB Length = 501 Score = 31.6 bits (70), Expect = 1.3, Method: Compositional matrix adjust. Identities = 20/82 (24%), Positives = 36/82 (43%), Gaps = 2/82 (2%) Query: 553 KLYGHGFEITCLDISPDQKLIASACR--SNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 + + FEI D + + C S+ V +VI I E+ L + P + H + I Sbjct: 261 QTFARTFEIKFETPEGDHEYVHQTCYGLSDRVIASVIAIHGDESGLCLPPDVAAHQVVIV 320 Query: 611 RLKFSKDGKFLLSVCRDRKWAL 632 + F K + ++ CR+ + L Sbjct: 321 PIIFKKAAEEVMEACRELRSRL 342 >3I2N-A nrPDB Length = 357 Score = 31.6 bits (70), Expect = 1.3, Method: Compositional matrix adjust. Identities = 18/65 (27%), Positives = 36/65 (55%), Gaps = 3/65 (4%) Query: 670 FVTASRDKTVKVW--RHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENG 727 VT SRD TVKVW R + +P + + ++ + ++ ++ +E+ ++ G +NG Sbjct: 132 IVTGSRDGTVKVWDPRQKDDPVAN-MEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNG 190 Query: 728 EIYLY 732 +I L+ Sbjct: 191 DIKLF 195 >5L9T-R nrPDB Length = 493 Score = 31.6 bits (70), Expect = 1.4, Method: Compositional matrix adjust. Identities = 20/83 (24%), Positives = 37/83 (44%), Gaps = 14/83 (16%) Query: 55 LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP 114 L+GH EV +++ D + S D+ + +W + S +Q Y++ + A+ A+ Sbjct: 309 LQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLS------PVQQYTEHLAAVKAIA 362 Query: 115 ------SLISV--GCADGTISIW 129 L++ G AD I W Sbjct: 363 WSPHQHGLLASGGGTADRCIRFW 385 >5FA5-B nrPDB Length = 367 Score = 31.6 bits (70), Expect = 1.4, Method: Compositional matrix adjust. Identities = 17/50 (34%), Positives = 28/50 (56%), Gaps = 4/50 (8%) Query: 38 IALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSD-FMVSASEDHHVKIW 86 I +WD + + V ++ + H A+VTCV P D +S SED+ + +W Sbjct: 174 IKVWDLAQ---QVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLW 220 >5A31-R nrPDB Length = 386 Score = 30.8 bits (68), Expect = 2.4, Method: Compositional matrix adjust. Identities = 20/65 (30%), Positives = 28/65 (43%), Gaps = 3/65 (4%) Query: 37 TIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQC 96 + LWD N+ A LKGH V + D +VS + D ++ WK D S L Sbjct: 325 NLTLWDC---NSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKLFDVSVLNL 381 Query: 97 IQTIQ 101 I+ Sbjct: 382 FTRIR 386 >4AEZ-A nrPDB Length = 401 Score = 30.8 bits (68), Expect = 2.4, Method: Compositional matrix adjust. Identities = 36/163 (22%), Positives = 63/163 (38%), Gaps = 23/163 (14%) Query: 266 ELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGE 325 ++R+ + + GH + L W LQL + D + +W D S I + + Sbjct: 202 DVRIANHQIGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIW--DARSSI----PKFTK 255 Query: 326 MSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRM--WATKDNIICDQRLGISG 383 + A A W C W + + T G T ++ W N R+ Sbjct: 256 TNHNAAVKAVA-----W-CPW----QSNLLATGGGTMDKQIHFW----NAATGARVNTVD 301 Query: 384 ATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREI 426 A VT + WSP + +++T L + W Y +SG +++ Sbjct: 302 AGSQVTSLIWSPHSKEIMSTHGFPDNNL-SIWSYSSSGLTKQV 343 Score = 29.6 bits (65), Expect = 5.2, Method: Compositional matrix adjust. Identities = 46/199 (23%), Positives = 79/199 (39%), Gaps = 35/199 (17%) Query: 53 ATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIW-------KFTDYSHLQCIQTIQ--HY 103 TL+GH +EV + + D + S D+ V+IW KFT +H ++ + + Sbjct: 211 GTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPW 270 Query: 104 SKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEE 163 ++A G D I W N G A T+ G SL Sbjct: 271 QSNLLATGG-------GTMDKQIHFW-----NAATG-ARVNTVDAG---SQVTSLIWSPH 314 Query: 164 KKYLLAIGG-TNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLC 222 K +++ G + N+ I S+ S SG+ K ++ H+ V A +P +L Sbjct: 315 SKEIMSTHGFPDNNLSIWSY--SSSGLTKQ---VDIPAHDTRVLYSAL----SPDGRILS 365 Query: 223 SGSQDRYIRLWRIRINDLI 241 + + D ++ WR+ D + Sbjct: 366 TAASDENLKFWRVYDGDHV 384 >5WLC-LL nrPDB Length = 643 Score = 30.0 bits (66), Expect = 4.1, Method: Compositional matrix adjust. Identities = 21/93 (22%), Positives = 43/93 (46%), Gaps = 8/93 (8%) Query: 143 EFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHE 202 +F + + F C+ L+K+ ++ G + + +AS +S IE+ +VV GH Sbjct: 133 QFKLLQHFRINNCVQLNKLT----IVPAGDSVAQLLVASHSISLIDIEEKKVVMTFPGHV 188 Query: 203 DWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI 235 V +L Q ++ + DR++ ++ I Sbjct: 189 SPVSTL----QVITNEFFISGAEGDRFLNVYDI 217 >5IXM-A nrPDB Length = 577 Score = 30.0 bits (66), Expect = 4.4, Method: Compositional matrix adjust. Identities = 17/60 (28%), Positives = 26/60 (43%) Query: 253 LLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDE 312 SN ++F + + NF+A I H LQW LLA + T + W P++ Sbjct: 31 FTSNNGFEFLLPYYWNIAPNFDATITPHYMERRGLQWQNEFRYLLAPGSGTMALDWLPND 90 >2ZBT-A nrPDB Length = 297 Score = 29.6 bits (65), Expect = 4.7, Method: Compositional matrix adjust. Identities = 11/28 (39%), Positives = 17/28 (60%) Query: 61 EVTCVRFVPDSDFMVSASEDHHVKIWKF 88 E V F+ +S+ + A E+HH+ WKF Sbjct: 97 EAIGVDFIDESEVLTPADEEHHIDKWKF 124 >5YZG-2 nrPDB Length = 646 Score = 29.6 bits (65), Expect = 4.8, Method: Compositional matrix adjust. Identities = 18/48 (37%), Positives = 26/48 (54%), Gaps = 13/48 (27%) Query: 62 VTCVRFVPDSDFMVSASEDHHVKIWK-------FTDY--SHLQCIQTI 100 V C + +DF+++AS D HVK WK F + SHL I++I Sbjct: 96 VVCTK----TDFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESI 139 >3NA6-A nrPDB Length = 331 Score = 29.6 bits (65), Expect = 5.2, Method: Compositional matrix adjust. Identities = 17/64 (26%), Positives = 35/64 (54%), Gaps = 5/64 (7%) Query: 702 KAVTAISIHDSMIREKILI----SVGLENGEIYLYSYTLGKFELITQLNEDITPADKITR 757 K + + IH +++ ++ I ++ + +G+ YL+S G FE++ L E + D + R Sbjct: 227 KGLRNVLIHFGILQGEMQIDPSVTLDMPDGDCYLFSEHDGLFEIMIDLGEPVQEGDLVAR 286 Query: 758 LRWS 761 + WS Sbjct: 287 V-WS 289 >3DWL-C nrPDB Length = 377 Score = 29.6 bits (65), Expect = 5.5, Method: Compositional matrix adjust. Identities = 32/137 (23%), Positives = 60/137 (43%), Gaps = 11/137 (8%) Query: 54 TLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIW-KFTDYSHLQCIQTIQ-HYSKTIVALS 111 T H+ VTCV + P S+ +V+ S+D + ++ K D + Q + ++ + + T V S Sbjct: 50 TFSDHDKIVTCVDWAPKSNRIVTCSQDRNAYVYEKRPDGTWKQTLVLLRLNRAATFVRWS 109 Query: 112 ALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVE--EKKYLLA 169 +VG IS+ +ND + + K PL ++ ++ LLA Sbjct: 110 PNEDKFAVGSGARVISVCYFEQENDWW-------VSKHLKRPLRSTILSLDWHPNNVLLA 162 Query: 170 IGGTNVNVFIASFILSD 186 G + ++ S + D Sbjct: 163 AGCADRKAYVLSAYVRD 179 >5WYJ-BE nrPDB Length = 939 Score = 29.3 bits (64), Expect = 6.7, Method: Compositional matrix adjust. Identities = 34/128 (26%), Positives = 49/128 (38%), Gaps = 8/128 (6%) Query: 44 IEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQ-TIQH 102 I+ + V L GH +T F P+ ++VSAS D ++ W D CI I Sbjct: 570 IDAVTQRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTW---DLPTGGCIDGIIVD 626 Query: 103 YSKTIVALSALPSLISVGCADGT-ISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKV 161 T V S L++ G I IW Q F TI + F + L + V Sbjct: 627 NVATNVKFSPNGDLLATTHVTGNGICIWTNRAQ---FKTVSTRTIDESEFARMALPSTSV 683 Query: 162 EEKKYLLA 169 +L+ Sbjct: 684 RGNDSMLS 691 >2P9P-C nrPDB Length = 372 Score = 29.3 bits (64), Expect = 6.7, Method: Compositional matrix adjust. Identities = 12/32 (37%), Positives = 19/32 (59%) Query: 55 LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIW 86 LK H +VT V + PDS+ +V+ D + +W Sbjct: 48 LKEHNGQVTGVDWAPDSNRIVTCGTDRNAYVW 79 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4XFV-A nrPDB 1131 0.0 5FL8-q nrPDB 294 1e-79 4J0W-A nrPDB 225 7e-59 6QX9-5O nrPDB 207 2e-53 5MZH-A nrPDB 205 7e-53 1VYH-C nrPDB 200 2e-51 4V8M-A7 nrPDB 196 2e-50 5NNZ-B nrPDB 193 3e-49 4BTS-AR nrPDB 184 1e-46 5M25-A nrPDB 175 6e-44 5UZ7-B nrPDB 173 2e-43 4YCZ-A nrPDB 173 3e-43 2H9P-A nrPDB 171 1e-42 6MZM-G nrPDB 169 5e-42 6F3T-A nrPDB 169 5e-42 5OPT-p nrPDB 168 9e-42 3JAP-g nrPDB 167 2e-41 3JRP-A nrPDB 166 3e-41 4BZK-B nrPDB 162 4e-40 3FM0-A nrPDB 160 3e-39 5K1B-B nrPDB 159 4e-39 6EMK-B nrPDB 157 1e-38 5FVM-C nrPDB 156 3e-38 3DM0-A nrPDB 151 1e-36 5WLC-LO nrPDB 149 5e-36 6HQA-B nrPDB 148 9e-36 5I2T-A nrPDB 148 1e-35 5NZU-C nrPDB 148 1e-35 5OQL-J nrPDB 147 2e-35 3MKQ-A nrPDB 146 4e-35 6Q8F-A nrPDB 145 5e-35 2YNP-A nrPDB 144 2e-34 5XYI-g nrPDB 143 4e-34 5Z56-q nrPDB 141 2e-33 6GMH-W nrPDB 138 7e-33 4LG8-A nrPDB 136 2e-32 6J6H-n nrPDB 135 6e-32 5WYK-BB nrPDB 133 3e-31 5K19-A nrPDB 124 1e-28 2HES-X nrPDB 118 1e-26 5GAN-H nrPDB 106 4e-23 Sequences not found previously or not previously below threshold: 3JRO-A nrPDB 176 3e-44 6G51-g nrPDB 147 2e-35 6HHQ-h nrPDB 141 9e-34 4V7E-Bg nrPDB 141 1e-33 4V6W-Ag nrPDB 140 2e-33 6N9G-C nrPDB 136 2e-32 4L9O-A nrPDB 135 6e-32 6QX9-4B nrPDB 130 3e-30 3BG0-A nrPDB 125 1e-28 6ID0-T nrPDB 122 6e-28 5Y88-O nrPDB 115 6e-26 5WYJ-BC nrPDB 115 7e-26 5WBU-D nrPDB 114 2e-25 3JB9-L nrPDB 110 3e-24 3JB9-g nrPDB 108 1e-23 6EOJ-D nrPDB 107 2e-23 1NR0-A nrPDB 104 1e-22 5YZG-W nrPDB 103 3e-22 6QDV-o nrPDB 103 3e-22 5A9Q-7 nrPDB 101 9e-22 4A11-B nrPDB 101 1e-21 6ELZ-p nrPDB 98 1e-20 6BX3-A nrPDB 98 2e-20 3F3P-A nrPDB 97 4e-20 3C9C-A nrPDB 96 6e-20 5WLC-LU nrPDB 95 8e-20 5OQL-L nrPDB 95 1e-19 3CFV-B nrPDB 95 2e-19 5Y1U-A nrPDB 94 2e-19 5L9T-R nrPDB 93 3e-19 5G04-R nrPDB 93 6e-19 5WJC-A nrPDB 92 9e-19 5K0Y-T nrPDB 91 1e-18 4GGA-A nrPDB 91 2e-18 5LCW-Q nrPDB 91 2e-18 5CXC-A nrPDB 89 7e-18 4N14-A nrPDB 89 8e-18 5WLC-LJ nrPDB 85 8e-17 4U1E-I nrPDB 85 9e-17 6CHG-A nrPDB 85 2e-16 4AEZ-A nrPDB 84 2e-16 5OQL-X nrPDB 83 3e-16 3ODT-A nrPDB 83 4e-16 4XYI-A nrPDB 83 4e-16 6CB1-s nrPDB 81 2e-15 2PM9-A nrPDB 80 3e-15 6C0F-s nrPDB 80 3e-15 6EM1-m nrPDB 80 4e-15 5OQL-d nrPDB 80 4e-15 3JZG-A nrPDB 79 8e-15 5BJS-A nrPDB 78 1e-14 4J0X-A nrPDB 78 1e-14 3W15-A nrPDB 78 1e-14 5CXB-B nrPDB 78 1e-14 5WYJ-BE nrPDB 78 2e-14 5WLC-SG nrPDB 78 2e-14 5A31-R nrPDB 76 4e-14 4OWR-A nrPDB 76 6e-14 4BH6-A nrPDB 75 1e-13 5MWJ-A nrPDB 75 1e-13 4G56-B nrPDB 73 3e-13 5N4A-A nrPDB 73 4e-13 5FA5-B nrPDB 73 6e-13 4PSX-B nrPDB 71 1e-12 2AQ5-A nrPDB 71 1e-12 3ACP-A nrPDB 71 2e-12 6E29-D nrPDB 71 3e-12 5WLC-LN nrPDB 64 3e-10 2P9P-C nrPDB 63 6e-10 5A9Q-0 nrPDB 62 9e-10 6CHG-D nrPDB 59 7e-09 6BX3-B nrPDB 59 7e-09 5YZG-2 nrPDB 59 8e-09 3I2N-A nrPDB 59 1e-08 1PI6-A nrPDB 59 1e-08 4E5Z-B nrPDB 58 2e-08 5A9Q-2 nrPDB 58 2e-08 6F1U-h nrPDB 57 3e-08 5OV3-A nrPDB 56 5e-08 3DWL-C nrPDB 56 8e-08 5MC6-j nrPDB 55 1e-07 5WLC-LH nrPDB 55 2e-07 5M89-A nrPDB 54 2e-07 3EI3-B nrPDB 53 4e-07 5AMS-A nrPDB 51 2e-06 6IYY-A nrPDB 49 9e-06 5TF2-A nrPDB 46 6e-05 5WLC-LS nrPDB 46 8e-05 5WLC-LW nrPDB 45 1e-04 2I3T-A nrPDB 45 1e-04 3DW8-B nrPDB 45 2e-04 4FHN-A nrPDB 45 2e-04 4AV8-A nrPDB 43 7e-04 2VDU-B nrPDB 41 0.002 5LTD-A nrPDB 39 0.006 6CVZ-A nrPDB 38 0.012 5K1H-B nrPDB 36 0.054 3FGB-A nrPDB 36 0.073 4YHC-A nrPDB 35 0.11 4MHC-A nrPDB 35 0.11 3JB9-S nrPDB 34 0.27 5GRS-A nrPDB 34 0.27 3T8I-A nrPDB 34 0.30 5BPW-A nrPDB 33 0.65 5BPT-A nrPDB 32 0.93 6N8P-A nrPDB 30 4.2 5CWW-B nrPDB 30 5.0 5IXM-A nrPDB 30 5.1 6GB2-BE nrPDB 29 6.4 4CE4-E nrPDB 29 6.5 1K3I-A nrPDB 29 7.4 >4XFV-A nrPDB Length = 792 Score = 1131 bits (2924), Expect = 0.0, Method: Composition-based stats. Identities = 788/788 (100%), Positives = 788/788 (100%) Query: 1 MVECITPEAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEA 60 MVECITPEAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEA Sbjct: 5 MVECITPEAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEA 64 Query: 61 EVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVG 120 EVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVG Sbjct: 65 EVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVG 124 Query: 121 CADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIA 180 CADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIA Sbjct: 125 CADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIA 184 Query: 181 SFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDL 240 SFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDL Sbjct: 185 SFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDL 244 Query: 241 IDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAAT 300 IDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAAT Sbjct: 245 IDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAAT 304 Query: 301 ADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGK 360 ADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGK Sbjct: 305 ADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGK 364 Query: 361 TGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDAS 420 TGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDAS Sbjct: 365 TGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDAS 424 Query: 421 GRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVG 480 GRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVG Sbjct: 425 GRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVG 484 Query: 481 IQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMED 540 IQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMED Sbjct: 485 IQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMED 544 Query: 541 QLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKP 600 QLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKP Sbjct: 545 QLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKP 604 Query: 601 ALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDAD 660 ALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDAD Sbjct: 605 ALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDAD 664 Query: 661 WAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILI 720 WAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILI Sbjct: 665 WAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILI 724 Query: 721 SVGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLST 780 SVGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLST Sbjct: 725 SVGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLST 784 Query: 781 RIYSLAYE 788 RIYSLAYE Sbjct: 785 RIYSLAYE 792 >5FL8-q nrPDB Length = 515 Score = 294 bits (752), Expect = 1e-79, Method: Composition-based stats. Identities = 77/409 (18%), Positives = 155/409 (37%), Gaps = 67/409 (16%) Query: 24 HKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHV 83 H ++V T +WD + + TLKGH V CV + PD + + + S D+ + Sbjct: 154 HTSSRMVTGAGDNTARIWDC---DTQTPMHTLKGHYNWVLCVSWSPDGEVIATGSMDNTI 210 Query: 84 KIWKFTDYSHLQCI-QTIQHYSKTIVALSALP---------SLISVGCADGTISIWRQNI 133 ++W D QC+ ++ +SK I +LS P ++ DGTI IW Sbjct: 211 RLW---DPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDT-- 265 Query: 134 QNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCR 193 ++T+ C+ + LL G + V + + R Sbjct: 266 ----VSRVCQYTMSGHTNSVSCVKWG----GQGLLYSGSHDRTVRVWDIN------SQGR 311 Query: 194 VVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRY---------IRLWRIRINDLIDDS 244 + L+ H WV L+ DY L G+ D + + + I Sbjct: 312 CINILKSHAHWVNHLSLS-----TDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKK 366 Query: 245 EEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTS 304 +S+++ + ++ Y + + L+ A + GH ++ + + +++A+ D S Sbjct: 367 NGNSEEMMVTASDDYTMFLWNPLK-STKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNS 425 Query: 305 LMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSW 364 + +W D G ++ + R G + W + R+ ++ K + Sbjct: 426 IKLW--DGRDGKFISTFR-------------GHVASVYQVAWSSDCRL--LVSCSKDTTL 468 Query: 365 RMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFA 413 ++W + + + + G +V + WS G+ + + D+ RL+ Sbjct: 469 KVWDVRTRKL---SVDLPGHKDEVYTVDWSVDGKRVCSGGKDKMVRLWT 514 Score = 160 bits (403), Expect = 3e-39, Method: Composition-based stats. Identities = 79/422 (18%), Positives = 143/422 (33%), Gaps = 62/422 (14%) Query: 57 GHEAEVTCVRFVP-DSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS 115 GH + + C F P S MV+ + D+ +IW D + T++ + ++ +S P Sbjct: 141 GHGSTILCSAFAPHTSSRMVTGAGDNTARIW---DCDTQTPMHTLKGHYNWVLCVSWSPD 197 Query: 116 --LISVGCADGTISIWRQNIQND--EFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIG 171 +I+ G D TI +W + H I + P+ L K LA Sbjct: 198 GEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHL---VKPGSKPRLASS 254 Query: 172 GTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIR 231 + + I + + GH + V + + Q LL SGS DR +R Sbjct: 255 SKDGTIKIWDTVSRV-------CQYTMSGHTNSVSCVKWGGQG-----LLYSGSHDRTVR 302 Query: 232 LWRI--RINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQ- 288 +W I + + L + Y +I G + + + Sbjct: 303 VWDINSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEK 362 Query: 289 ----WHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSC 344 S ++ A+ D ++ +W P G Sbjct: 363 ICKKNGNSEEMMVTASDDYTMFLWNP--------LKSTKPIARMTGHQKLVNHVA----- 409 Query: 345 LWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATS 404 F+ + + ++ S ++W +D G V +AWS L++ S Sbjct: 410 --FSPDGR-YIVSASFDNSIKLWDGRDGKFIS---TFRGHVASVYQVAWSSDCRLLVSCS 463 Query: 405 LDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVE-TVTDTRFVSGGDEKILR 463 D T + ++D RK + P H ++ V+ +V R SGG +K++R Sbjct: 464 KDTTLK-----VWDVRTRKLSVDL------PG-HKDEVYTVDWSVDGKRVCSGGKDKMVR 511 Query: 464 SF 465 + Sbjct: 512 LW 513 Score = 141 bits (356), Expect = 9e-34, Method: Composition-based stats. Identities = 62/356 (17%), Positives = 116/356 (32%), Gaps = 72/356 (20%) Query: 6 TPEAIFIGA-NKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTC 64 TP G N VS + I TI LWDP G L+GH +T Sbjct: 177 TPMHTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLG--DALRGHSKWITS 234 Query: 65 VRFVP-------DSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS-L 116 + + P + S+S+D +KIW C T+ ++ ++ + L Sbjct: 235 LSWEPIHLVKPGSKPRLASSSKDGTIKIWDTV---SRVCQYTMSGHTNSVSCVKWGGQGL 291 Query: 117 ISVGCADGTISIWRQNIQND--EFGLAHEFTIKKGFFY----------------PLCLS- 157 + G D T+ +W N Q +H + P Sbjct: 292 LYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEE 351 Query: 158 ------------LSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWV 205 K + ++ + +F+ + ++ + +A + GH+ V Sbjct: 352 AQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWN------PLKSTKPIARMTGHQKLV 405 Query: 206 KSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSK-----------KLTLL 254 +AF P + S S D I+LW R I +L + Sbjct: 406 NHVAFS----PDGRYIVSASFDNSIKLWDGRDGKFISTFRGHVASVYQVAWSSDCRLLVS 461 Query: 255 SNKQYKFQIDD--ELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVW 308 +K ++ D ++ ++ + GH D + ++ W ++ + D + +W Sbjct: 462 CSKDTTLKVWDVRTRKLSVD----LPGHKDEVYTVDWSVDGKRVCSGGKDKMVRLW 513 Score = 129 bits (324), Expect = 4e-30, Method: Composition-based stats. Identities = 76/500 (15%), Positives = 160/500 (32%), Gaps = 126/500 (25%) Query: 193 RVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLT 252 R + + GH + AF + + +G+ D R+W Sbjct: 134 RSSSAIAGHGSTILCSAFAPHTSSR---MVTGAGDNTARIWDCDTQ-------------- 176 Query: 253 LLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDE 312 + GH +W+ + W + + D ++ +W+P Sbjct: 177 -------------------TPMHTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKS 217 Query: 313 TSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERM------DFFLTNGKTGSWRM 366 + A + + L + + ++ K G+ ++ Sbjct: 218 GQCL---------------GDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKI 262 Query: 367 WATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREI 426 W T + + +SG T V+ + W G L + S D+T R ++D + + R I Sbjct: 263 WDTVSRVC---QYTMSGHTNSVSCVKWGGQG-LLYSGSHDRTVR-----VWDINSQGRCI 313 Query: 427 ATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEK 486 + H + + + TD G + + K Sbjct: 314 NIL------KSHAHWVNHLSLSTDYALRIGAFDHTGK----------------------K 345 Query: 487 SEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHL 546 P+ A L K + + N ++ + T + +PL + Sbjct: 346 PSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKSTK------------ 393 Query: 547 LWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKP--ALPF 604 + ++ GH + + SPD + I SA N+++ + + K Sbjct: 394 ---PIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLW--------DGRDGKFISTFRG 442 Query: 605 HSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPL 664 H ++ ++ +S D + L+S +D +W+ + +L H ++ DW+ Sbjct: 443 HVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDL-----PGHKDEVYTVDWS-- 495 Query: 665 EFGNVFVTASRDKTVKVWRH 684 G + +DK V++W H Sbjct: 496 VDGKRVCSGGKDKMVRLWTH 515 Score = 101 bits (252), Expect = 9e-22, Method: Composition-based stats. Identities = 32/162 (19%), Positives = 66/162 (40%), Gaps = 18/162 (11%) Query: 24 HKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHV 83 + + +V T+ LW+P++ A + GH+ V V F PD ++VSAS D+ + Sbjct: 369 NSEEMMVTASDDYTMFLWNPLKST--KPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSI 426 Query: 84 KIWKFTDYSHLQCIQTIQHYSKTIVALSALPS--LISVGCADGTISIWRQNIQNDEFGL- 140 K+W D + T + + ++ ++ L+ D T+ +W + L Sbjct: 427 KLWDGRDGKFIS---TFRGHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDLP 483 Query: 141 AHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASF 182 H+ + + + K + + GG + V + + Sbjct: 484 GHKDEVYTVDWSV---------DGKRVCS-GGKDKMVRLWTH 515 Score = 76.5 bits (186), Expect = 4e-14, Method: Composition-based stats. Identities = 36/166 (21%), Positives = 64/166 (38%), Gaps = 23/166 (13%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 + L GH + C+ SPD ++IA+ N IR++ ++ + AL HS IT Sbjct: 179 MHTLKGHYNWVLCVSWSPDGEVIATGSMDNT-----IRLWDPKSGQCLGDALRGHSKWIT 233 Query: 611 RLKFSK-------DGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAP 663 L + L S +D +W+ + + HT + W Sbjct: 234 SLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTM-----SGHTNSVSCVKWG- 287 Query: 664 LEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISI 709 + + S D+TV+VW + +L++ H V +S+ Sbjct: 288 --GQGLLYSGSHDRTVRVWDINSQGRCINILKS---HAHWVNHLSL 328 Score = 76.5 bits (186), Expect = 4e-14, Method: Composition-based stats. Identities = 34/201 (16%), Positives = 65/201 (32%), Gaps = 36/201 (17%) Query: 554 LYGHGFEITCLDISPDQKL-IASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRL 612 + GHG I C +P + + N RI+ + + L H + + Sbjct: 139 IAGHGSTILCSAFAPHTSSRMVTGAGDNTA-----RIWDCDTQTPMH-TLKGHYNWVLCV 192 Query: 613 KFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLE-----FG 667 +S DG+ + + D LW+ + H++ I W P+ Sbjct: 193 SWSPDGEVIATGSMDNTIRLWDPKSGQ----CLGDALRGHSKWITSLSWEPIHLVKPGSK 248 Query: 668 NVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENG 727 ++S+D T+K+W HT +V+ + G Sbjct: 249 PRLASSSKDGTIKIWDTVSRVCQ----YTMSGHTNSVSCVKWG----------------G 288 Query: 728 EIYLYSYTLGKFELITQLNED 748 + LYS + + + +N Sbjct: 289 QGLLYSGSHDRTVRVWDINSQ 309 Score = 69.9 bits (169), Expect = 4e-12, Method: Composition-based stats. Identities = 27/168 (16%), Positives = 60/168 (35%), Gaps = 19/168 (11%) Query: 558 GFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKD 617 +E C ++++ +A + + +++ + + H + + FS D Sbjct: 359 NYEKICKKNGNSEEMMVTAS-----DDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPD 413 Query: 618 GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDK 677 G++++S D LW+ R H ++ W+ + V+ S+D Sbjct: 414 GRYIVSASFDNSIKLWDGRDGKFISTFR-----GHVASVYQVAWS--SDCRLLVSCSKDT 466 Query: 678 TVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLE 725 T+KVW + + H V + + K + S G + Sbjct: 467 TLKVWDVRTR----KLSVDLPGHKDEVYTVDWS---VDGKRVCSGGKD 507 Score = 53.0 bits (125), Expect = 5e-07, Method: Composition-based stats. Identities = 63/378 (16%), Positives = 118/378 (31%), Gaps = 75/378 (19%) Query: 370 KDNIICDQRLGISGATKDVTDIAWSP-SGEYLLATSLDQTTRLFAPWIYDASGRKREIAT 428 K + I+G + A++P + ++ + D T R++ Sbjct: 128 KVKPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIW---------DCDTQTP 178 Query: 429 WHEFSRPQIHGYDMICVE-TVTDTRFVSGGDEKILRSFDLPKG--VAGMLQ---KFVGIQ 482 H + H ++CV + +G + +R +D G + L+ K++ Sbjct: 179 MHTL---KGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSL 235 Query: 483 FEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQL 542 E + + P L S+K G T I D +S + Sbjct: 236 SWEPIHLVKPGSKPRLASSSKDG-----------------TIKIWDTVSRV--------- 269 Query: 543 QRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPAL 602 + GH ++C+ Q L+ S + +R++ + L Sbjct: 270 -------CQYTMSGHTNSVSCVKWG-GQGLLYSGSH-----DRTVRVWDINSQGRCINIL 316 Query: 603 PFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWA 662 H+ + L S D L D E + K + + +I Sbjct: 317 KSHAHWVNHLSLSTD-YALRIGAFDHT-----GKKPSTPEEAQKKALENYEKICKKNG-- 368 Query: 663 PLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISV 722 + VTAS D T+ +W K + H K V ++ + ++S Sbjct: 369 --NSEEMMVTASDDYTMFLWNPLKSTKP---IARMTGHQKLVNHVAFSPDG---RYIVSA 420 Query: 723 GLENGEIYLYSYTLGKFE 740 +N I L+ GKF Sbjct: 421 SFDNS-IKLWDGRDGKFI 437 >4J0W-A nrPDB Length = 343 Score = 225 bits (572), Expect = 7e-59, Method: Composition-based stats. Identities = 54/236 (22%), Positives = 95/236 (40%), Gaps = 36/236 (15%) Query: 550 EVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIR-------IFSTENWLEIKPAL 602 ++ L GH ITCL ++PD I SA + ++ + I + E KP Sbjct: 6 DIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKP-- 63 Query: 603 PFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWA 662 P HS + + S DGK+L S R + +WE + + + + A Sbjct: 64 PGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAV-------SGLA 116 Query: 663 PLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISV 722 + + S D++VKVW A++ +E H AV A+ D++ RE + + Sbjct: 117 FRRGTHQLYSTSHDRSVKVWNV----AENSYVETLFGHQDAVAAL---DALSRECCVTAG 169 Query: 723 GLE----------NGEIYLYSYTLGKFELITQLNED--ITPADKITRLRWSHLKRN 766 G + ++ Y + G + I +NE+ ++ AD + W K+ Sbjct: 170 GRDGTVRVWKIPEESQLVFYGHQ-GSIDCIHLINEEHMVSGADDGSVALWGLSKKR 224 Score = 95.0 bits (234), Expect = 1e-19, Method: Composition-based stats. Identities = 47/353 (13%), Positives = 101/353 (28%), Gaps = 70/353 (19%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNKGVYATLK--------GHEAEVTCVRFVPDSDFMVS 76 I + +I W V K GH + V C+ D ++ S Sbjct: 25 DDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLAS 84 Query: 77 ASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSAL--PSLISVGCADGTISIWRQNIQ 134 + IW+ H + T + + L+ + D ++ +W Sbjct: 85 GDRSKLILIWEAQSCQH---LYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNV--- 138 Query: 135 NDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRV 194 A ++ F + ++ ++ + GG + V + + Sbjct: 139 ------AENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLV----- 187 Query: 195 VAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLL 254 GH+ + + ++E + SG+ D + LW + K L Sbjct: 188 ---FYGHQGSIDCIHLINEEH-----MVSGADDGSVALWGL-------------SKKRPL 226 Query: 255 SNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETS 314 + ++ + E + F WISS+ + + + + + +W+ E Sbjct: 227 ALQREAHGLRGEPGLEQPF---------WISSVAALLNTDLVATGSHSSCVRLWQCGEGF 277 Query: 315 GIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMW 367 + + GF + L F+ G+ W Sbjct: 278 RQLDLLCDIPLV-------------GFINSLKFSSSGDFLVAGVGQEHRLGRW 317 Score = 83.0 bits (203), Expect = 4e-16, Method: Composition-based stats. Identities = 48/260 (18%), Positives = 91/260 (35%), Gaps = 31/260 (11%) Query: 14 ANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDF 73 ++ ++ K + + K I +W E + T GH V+ + F + Sbjct: 67 SSHVLCMAISSDGKYLASGDRSKLILIW---EAQSCQHLYTFTGHRDAVSGLAFRRGTHQ 123 Query: 74 MVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNI 133 + S S D VK+W + S+++ + Q + ALS ++ G DGT+ +W+ Sbjct: 124 LYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALS-RECCVTAGGRDGTVRVWKIPE 182 Query: 134 QNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCR 193 ++ H+ +I + + G + +V + + R Sbjct: 183 ESQLVFYGHQGSI-----------DCIHLINEEHMVSGADDGSVALWGLSKKRP-LALQR 230 Query: 194 VVAELEGHED-----WVKSLAFRHQETPGDYLLCSGSQDRYIRLWR----IRINDLIDDS 244 L G W+ S+A L+ +GS +RLW+ R DL+ D Sbjct: 231 EAHGLRGEPGLEQPFWISSVA----ALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDI 286 Query: 245 E--EDSKKLTLLSNKQYKFQ 262 L S+ + Sbjct: 287 PLVGFINSLKFSSSGDFLVA 306 Score = 81.5 bits (199), Expect = 1e-15, Method: Composition-based stats. Identities = 56/394 (14%), Positives = 115/394 (29%), Gaps = 77/394 (19%) Query: 52 YATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTI--------QHY 103 L+GH+ +TC+ PD + SA++D + W L I + Sbjct: 7 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 66 Query: 104 SKTIVALSALPSLISVGCADGT--ISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKV 161 S ++ ++ + D + I IW H +T L+ + Sbjct: 67 SSHVLCMAISSDGKYLASGDRSKLILIWEAQS------CQHLYTFTGHRDAVSGLAFRRG 120 Query: 162 EEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLL 221 + Y + +V + + + V L GH+D V +L + + Sbjct: 121 THQLY---STSHDRSVKVWNVAENSY-------VETLFGHQDAVAAL----DALSRECCV 166 Query: 222 CSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHD 281 +G +D +R+W ++ + + GH Sbjct: 167 TAGGRDGTVRVW----------------------------------KIPEESQLVFYGHQ 192 Query: 282 DWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGF 341 I + +++ D S+ +W + + + + + G G F Sbjct: 193 GSIDCIHLINE-EHMVSGADDGSVALWGLSKKRPLAL------QREAHGLRGEPGLEQPF 245 Query: 342 WSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLL 401 W D T + R+W + L + + +S SG++L+ Sbjct: 246 WISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPLVGFINSLKFSSSGDFLV 305 Query: 402 AT-SLDQTTRLFAPWIYDASGRKREIATWHEFSR 434 A + + + R R Sbjct: 306 AGVGQEHRLGRW----WRIK-EARNSVCIIPLRR 334 Score = 69.2 bits (167), Expect = 6e-12, Method: Composition-based stats. Identities = 45/297 (15%), Positives = 86/297 (28%), Gaps = 60/297 (20%) Query: 195 VAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLL 254 + L GH+ + L TP D + S ++D I W + Sbjct: 7 IRVLRGHQLSITCLVV----TPDDSAIFSAAKDCSIIKWSVESGRK-------------- 48 Query: 255 SNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETS 314 + R E GH + + L + +++WE Sbjct: 49 --------LHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQ 100 Query: 315 GIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNII 374 ++ T TG + + + S ++W +N Sbjct: 101 HLY---------------TFTGHRDAVSGLAFRRGTHQLY--STSHDRSVKVWNVAENSY 143 Query: 375 CDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSR 434 + + G V + + A D T R ++ + + H+ S Sbjct: 144 VE---TLFGHQDAVAALDALSRECCVTAGGRDGTVR-----VWKIPEESQLVFYGHQGS- 194 Query: 435 PQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFV-GIQFEEKSEMP 490 + C+ + + VSG D+ + + L K LQ+ G++ E E P Sbjct: 195 -------IDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQP 244 Score = 63.8 bits (153), Expect = 3e-10, Method: Composition-based stats. Identities = 42/241 (17%), Positives = 84/241 (34%), Gaps = 35/241 (14%) Query: 274 EALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGAST 333 ++ GH I+ L + +A D S++ W + + V + KGA Sbjct: 7 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVI-----PRAKKGAEG 61 Query: 334 ATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAW 393 C+ + + + + ++ +W + C +G V+ +A+ Sbjct: 62 KPPGHSSHVLCMAISSDGK-YLASGDRSKLILIWEAQS---CQHLYTFTGHRDAVSGLAF 117 Query: 394 SPSGEYLLATSLDQTTRLF----APWIYDASGRKREIATWHEFSRPQIHGYDMICVETVT 449 L +TS D++ +++ ++ G + +A SR CV Sbjct: 118 RRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRE-------CCV---- 166 Query: 450 DTRFVSGGDEKILRSFDLPK-------GVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSN 502 +GG + +R + +P+ G G + I E D +V + GLS Sbjct: 167 ----TAGGRDGTVRVWKIPEESQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSK 222 Query: 503 K 503 K Sbjct: 223 K 223 Score = 53.8 bits (127), Expect = 3e-07, Method: Composition-based stats. Identities = 23/133 (17%), Positives = 51/133 (38%), Gaps = 15/133 (11%) Query: 8 EAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRF 67 E +F + + + + + A G T+ +W E + Y GH+ + C+ Sbjct: 145 ETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFY----GHQGSIDCIHL 200 Query: 68 VPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSK--------TIVALSA--LPSLI 117 + + + MVS ++D V +W + L + I +++A L+ Sbjct: 201 INE-EHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLV 259 Query: 118 SVGCADGTISIWR 130 + G + +W+ Sbjct: 260 ATGSHSSCVRLWQ 272 Score = 49.1 bits (115), Expect = 6e-06, Method: Composition-based stats. Identities = 27/137 (19%), Positives = 50/137 (36%), Gaps = 12/137 (8%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 VE L+GH + LD + + + R V+ I E + H +I Sbjct: 144 VETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKI-------PEESQLVFYGHQGSID 196 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELR----FKNEKPHTRIIWDADWAPLEF 666 + + + ++S D ALW + + R + E + W + A L Sbjct: 197 CIHLINE-EHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLN 255 Query: 667 GNVFVTASRDKTVKVWR 683 ++ T S V++W+ Sbjct: 256 TDLVATGSHSSCVRLWQ 272 >6QX9-5O nrPDB Length = 357 Score = 207 bits (525), Expect = 2e-53, Method: Composition-based stats. Identities = 50/199 (25%), Positives = 88/199 (44%), Gaps = 25/199 (12%) Query: 529 PLSLLEC-PPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVI 587 P +LL+ PP LQ ++ L GH E+ C P+ +ASA + +I Sbjct: 41 PGALLQAGPPRCSSLQAPIML-----LSGHEGEVYCCKFHPNGSTLASAGF-----DRLI 90 Query: 588 RIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFK 647 +++ + L HS + L ++ DG L S D+ A+W+ + R K Sbjct: 91 LLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGE-----RVK 145 Query: 648 NEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAI 707 K HT + ++ + + T S D TVK+W +K+ A + ++T V A+ Sbjct: 146 RLKGHTSFV-NSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQ-----TFQNTYQVLAV 199 Query: 708 SIHDSMIREKILISVGLEN 726 + +D+ +IS G++N Sbjct: 200 TFNDT---SDQIISGGIDN 215 Score = 177 bits (449), Expect = 1e-44, Method: Composition-based stats. Identities = 59/321 (18%), Positives = 120/321 (37%), Gaps = 47/321 (14%) Query: 6 TPEAIFIGANKQTQVSDIH-KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTC 64 P + G + H + + G + I LW+ + YATLKGH V Sbjct: 57 APIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDN--YATLKGHSGAVME 114 Query: 65 VRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADG 124 + + D + SAS D V +W ++ ++ + + P L+ G DG Sbjct: 115 LHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDG 174 Query: 125 TISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFIL 184 T+ +W +I+ + T + L ++ + ++ + GG + ++ + Sbjct: 175 TVKLW--DIRKKAAIQTFQNT-----YQVLAVTFNDTSDQ---IISGGIDNDIKVW---- 220 Query: 185 SDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIR-------- 236 + + ++ + GH D V L+ + L S + D +R+W +R Sbjct: 221 ---DLRQNKLTYTMRGHADSVTGLSLSSE----GSYLLSNAMDNTVRVWDVRPFAPKERC 273 Query: 237 ------------INDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWI 284 N L D K+ S ++ + + D I ++ + GH I Sbjct: 274 VKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVY-VWDTTSRRILYK--LPGHAGSI 330 Query: 285 SSLQWHESRLQLLAATADTSL 305 + + +H +++A++D L Sbjct: 331 NEVAFHPDEPIIISASSDKRL 351 Score = 123 bits (308), Expect = 3e-28, Method: Composition-based stats. Identities = 52/320 (16%), Positives = 97/320 (30%), Gaps = 40/320 (12%) Query: 100 IQHYSKTIVALSALP--SLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLS 157 + + + P S ++ D I +W D + G + Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYA---TLKGHSG----AVME 114 Query: 158 LSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPG 217 L + L + ++ E V L+GH +V S + G Sbjct: 115 LHYNTDGSMLFSASTDK--------TVAVWDSETGERVKRLKGHTSFVNSC---YPARRG 163 Query: 218 DYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQY----KFQIDDELRVGINF 273 L+C+GS D ++LW IR I + + L + N ID++++V Sbjct: 164 PQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLR 223 Query: 274 EALIM----GHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSK 329 + + GH D ++ L LL+ D ++ VW+ + C Sbjct: 224 QNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHN 283 Query: 330 GASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVT 389 C W +W T I + G + Sbjct: 284 FEK-------NLLRCSWSPDGSK--IAAGSADRFVYVWDTTSRRIL---YKLPGHAGSIN 331 Query: 390 DIAWSPSGEYLLATSLDQTT 409 ++A+ P +++ S D+ Sbjct: 332 EVAFHPDEPIIISASSDKRL 351 Score = 101 bits (251), Expect = 1e-21, Method: Composition-based stats. Identities = 46/321 (14%), Positives = 103/321 (32%), Gaps = 74/321 (23%) Query: 150 FFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLA 209 + + K LA G + + + + C A L+GH V L Sbjct: 63 SGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY------GDCDNYATLKGHSGAVMELH 116 Query: 210 FRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRV 269 + +L S S D+ + +W + + Sbjct: 117 YN----TDGSMLFSASTDKTVAVWDSETGERV---------------------------- 144 Query: 270 GINFEALIMGHDDWISSLQWHESRLQLL-AATADTSLMVWEPDETSGIWVCSLRLGEMSS 328 + GH +++S QL+ + D ++ +W+ + + I ++ Sbjct: 145 -----KRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAV 199 Query: 329 KGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDV 388 T+ D ++ G ++W + N + + G V Sbjct: 200 TFNDTS------------------DQIISGGIDNDIKVWDLRQNKL---TYTMRGHADSV 238 Query: 389 TDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYD---MICV 445 T ++ S G YLL+ ++D T R ++D + F + +H ++ + C Sbjct: 239 TGLSLSSEGSYLLSNAMDNTVR-----VWDVRPFAPKERCVKIF-QGNVHNFEKNLLRCS 292 Query: 446 ETVTDTRFVSGGDEKILRSFD 466 + ++ +G ++ + +D Sbjct: 293 WSPDGSKIAAGSADRFVYVWD 313 Score = 85.3 bits (209), Expect = 8e-17, Method: Composition-based stats. Identities = 69/378 (18%), Positives = 128/378 (33%), Gaps = 90/378 (23%) Query: 272 NFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGA 331 L+ GH+ + ++H + L +A D +++W Sbjct: 57 APIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGD--------------CDNY 102 Query: 332 STATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDI 391 +T G SG + T M F + + +W ++ + + G T V Sbjct: 103 ATLKGHSGAVMELHYNTDGSMLF--SASTDKTVAVWDSETGERVKR---LKGHTSFVNSC 157 Query: 392 AWSPSGEY-LLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTD 450 + G + S D T +L+ R+ A F + Y ++ V T D Sbjct: 158 YPARRGPQLVCTGSDDGTVKLW---------DIRKKAAIQTFQ----NTYQVLAV-TFND 203 Query: 451 T--RFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDD 508 T + +SGG + ++ +DL + + + + DS T GLS Sbjct: 204 TSDQIISGGIDNDIKVWDLRQN---------KLTYTMRGH-ADSVT----GLS------- 242 Query: 509 ANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQ----RHLLWPE--VEKLYG--HGFE 560 ++ S L M++ ++ R E V+ G H FE Sbjct: 243 -----------------LSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFE 285 Query: 561 --ITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDG 618 + SPD IA+ + + ++ T + I LP H+ +I + F D Sbjct: 286 KNLLRCSWSPDGSKIAAGS-----ADRFVYVWDTTSR-RILYKLPGHAGSINEVAFHPDE 339 Query: 619 KFLLSVCRDRKWALWERN 636 ++S D++ + E Sbjct: 340 PIIISASSDKRLYMGEIQ 357 Score = 64.9 bits (156), Expect = 1e-10, Method: Composition-based stats. Identities = 59/351 (16%), Positives = 115/351 (32%), Gaps = 70/351 (19%) Query: 381 ISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGY 440 +SG +V + P+G L + D+ L ++ G AT G Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILL-----WNVYGDCDNYATL-----KGHSGA 111 Query: 441 DMICVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGL 500 M + S +K + +D G +++ G S P + P L Sbjct: 112 VMELHYNTDGSMLFSASTDKTVAVWDSETG--ERVKRLKGHTSFVNSCYP-ARRGPQLVC 168 Query: 501 SNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFE 560 + G DD G + DI ++ + + + ++ Sbjct: 169 T---GSDD----------GTVKLWDIRKKAAI--------------------QTFQNTYQ 195 Query: 561 ITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKF 620 + + + I S N+++ +R ++ + H+ ++T L S +G + Sbjct: 196 VLAVTFNDTSDQIISGGIDNDIKVWDLR------QNKLTYTMRGHADSVTGLSLSSEGSY 249 Query: 621 LLSVCRDRKWALWE------RNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTAS 674 LLS D +W+ + F+ N + + W+P G+ S Sbjct: 250 LLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHN---FEKNLLRCSWSP--DGSKIAAGS 304 Query: 675 RDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLE 725 D+ V VW +L H ++ ++ H E I+IS + Sbjct: 305 ADRFVYVWDTTSR----RILYKLPGHAGSINEVAFHPD---EPIIISASSD 348 >5MZH-A nrPDB Length = 452 Score = 205 bits (521), Expect = 7e-53, Method: Composition-based stats. Identities = 74/364 (20%), Positives = 127/364 (34%), Gaps = 55/364 (15%) Query: 16 KQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRF-VPDSDFM 74 T + + + +T +W+ TL+GH+ V + F P D + Sbjct: 96 PLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEE---VFTLEGHKNVVYAIAFNNPYGDKI 152 Query: 75 VSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS--LISVGCADGTISIWRQN 132 V+ S D K+W T++ + IV LS P +I+ G D T +W Sbjct: 153 VTGSFDKTCKLWDAYTGQLY---YTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVE 209 Query: 133 IQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKC 192 + LA +SL GG + + Sbjct: 210 TGQERATLAGHRA--------EIVSLGFN--------TGGDLIVTGSFDHDSRLWDVRTG 253 Query: 193 RVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLT 252 + V L GH V S F + T L+ SGS D RLW +R + + + ++ Sbjct: 254 QCVHVLSGHRGEVSSTQFNYAGT----LVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVL 309 Query: 253 -----LLSNKQYKFQIDDELRVGINFEAL----IMGHDDWISSLQWHESRLQLLAATADT 303 K D R+ + ++GH+ IS + ++ +L+ A++D Sbjct: 310 DVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTRLITASSDK 369 Query: 304 SLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGS 363 + +W+ D + V G + +SC F +E DF +T K + Sbjct: 370 TCRLWDCDTGECLQVLE---------------GHTDEIFSCA-FNYEG-DFIITGSKDNT 412 Query: 364 WRMW 367 R+W Sbjct: 413 CRIW 416 Score = 173 bits (439), Expect = 2e-43, Method: Composition-based stats. Identities = 59/294 (20%), Positives = 101/294 (34%), Gaps = 37/294 (12%) Query: 28 KIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWK 87 KIV KT LWD +Y TLKGH+ E+ C+ F P S + + S D+ K+W Sbjct: 151 KIVTGSFDKTCKLWDAYTGQ---LYYTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWD 207 Query: 88 FTDYSHLQCIQTIQHYSKTIVAL--SALPSLISVGCADGTISIWRQNIQNDEFGLAHEFT 145 Q T+ + IV+L + LI G D +W H + Sbjct: 208 VETG---QERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQ----CVHVLS 260 Query: 146 IKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWV 205 +G + + L+ G + + + R ++ +GH D V Sbjct: 261 GHRGEVSSTQFNYAGT-----LVVSGSIDCTSRLW-------DVRSGRCLSVKQGHTDEV 308 Query: 206 KSLAFRHQETPGDYLLCSGSQDRYIRLWRI---RINDLIDDSEEDSKKLTLLSNKQYKFQ 262 +AF T + S S D RL+ + E + K+ Sbjct: 309 LDVAFDAAGTK----MVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTRLIT 364 Query: 263 IDDELRVGI------NFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEP 310 + + ++ GH D I S ++ ++ + D + +W+ Sbjct: 365 ASSDKTCRLWDCDTGECLQVLEGHTDEIFSCAFNYEGDFIITGSKDNTCRIWKA 418 Score = 119 bits (298), Expect = 5e-27, Method: Composition-based stats. Identities = 67/446 (15%), Positives = 134/446 (30%), Gaps = 111/446 (24%) Query: 191 KCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKK 250 + L H + + AF +GS DR ++W Sbjct: 83 SFTLFKVLRAHILPLTNCAFN----KSGDRFITGSYDRTCKVWN---------------- 122 Query: 251 LTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWH-ESRLQLLAATADTSLMVWE 309 T + + + GH + + ++ ++ +++ + D + +W+ Sbjct: 123 -TFTGEEVFT----------------LEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWD 165 Query: 310 PDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWAT 369 + + KG T CL F + T + ++W Sbjct: 166 AYTGQLYY---------TLKGHQTE-------IVCLSFN-PQSTIIATGSMDNTAKLWDV 208 Query: 370 KDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATW 429 + +R ++G ++ + ++ G+ ++ S D +RL+ R Sbjct: 209 ETG---QERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLW---------DVRTGQCV 256 Query: 430 HEFSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEM 489 H S G T VSG + R +D+ G Sbjct: 257 HVLS--GHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRC----------------- 297 Query: 490 PDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWP 549 LS K G D D + G K D + +L L Sbjct: 298 ----------LSVKQGHTDEVLDVAFDAAGTKMVSASADGSA---------RLYHTLTGV 338 Query: 550 EVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTI 609 L GH EI+ + +P + +A R++ + ++ L H+ I Sbjct: 339 CQHTLVGHEGEISKVAFNPQGTRLITASSDKTC-----RLWDCDTGECLQV-LEGHTDEI 392 Query: 610 TRLKFSKDGKFLLSVCRDRKWALWER 635 F+ +G F+++ +D +W+ Sbjct: 393 FSCAFNYEGDFIITGSKDNTCRIWKA 418 Score = 113 bits (282), Expect = 3e-25, Method: Composition-based stats. Identities = 58/407 (14%), Positives = 133/407 (32%), Gaps = 79/407 (19%) Query: 277 IMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATG 336 + H +++ +++S + + + D + VW ++ Sbjct: 90 LRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVF----------------TLE 133 Query: 337 SSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPS 396 + F + D +T + ++W + + G ++ ++++P Sbjct: 134 GHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLY---YTLKGHQTEIVCLSFNPQ 190 Query: 397 GEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSG 456 + S+D T +L+ +G++R H R +I + V+G Sbjct: 191 STIIATGSMDNTAKLWDVE----TGQERATLAGH---RAEI----VSLGFNTGGDLIVTG 239 Query: 457 GDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEE 516 + R +D+ G + G + E S + A V+ +G D + Sbjct: 240 SFDHDSRLWDVRTGQC--VHVLSGHRGEVSSTQFNYAGTLVV-----SGSIDCTSRLWDV 292 Query: 517 EGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASA 576 G ++ GH E+ + + SA Sbjct: 293 RSG------------------RCLSVK-----------QGHTDEVLDVAFDAAGTKMVSA 323 Query: 577 CRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERN 636 + R++ T + + H I+++ F+ G L++ D+ LW+ + Sbjct: 324 SADGSA-----RLYHTLTGVCQHTLV-GHEGEISKVAFNPQGTRLITASSDKTCRLWDCD 377 Query: 637 MEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWR 683 + + + HT I+ A G+ +T S+D T ++W+ Sbjct: 378 TGECL-----QVLEGHTDEIFSC--AFNYEGDFIITGSKDNTCRIWK 417 Score = 104 bits (258), Expect = 2e-22, Method: Composition-based stats. Identities = 65/380 (17%), Positives = 123/380 (32%), Gaps = 81/380 (21%) Query: 353 DFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWS-PSGEYLLATSLDQTTRL 411 D F+T + ++W T ++ + G V IA++ P G+ ++ S D+T +L Sbjct: 107 DRFITGSYDRTCKVWNTFTG---EEVFTLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKL 163 Query: 412 FAPWI----YDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDL 467 + + Y G + EI PQ T +G + + +D+ Sbjct: 164 WDAYTGQLYYTLKGHQTEIVCLS--FNPQ-------------STIIATGSMDNTAKLWDV 208 Query: 468 PKGVAGMLQKFVGIQFEEKSEMP-DSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDI 526 G +E++ + A + LG + GG D+ Sbjct: 209 ETG-------------QERATLAGHRAEIVSLGFNT---------------GG-----DL 235 Query: 527 TDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAV 586 S + +L V L GH E++ + L+ S Sbjct: 236 IVTGSF----DHDSRLWDVRTGQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTS---- 287 Query: 587 IRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRF 646 R++ + + H+ + + F G ++S D L+ L Sbjct: 288 -RLWDVRSGRCLSVK-QGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLV- 344 Query: 647 KNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTA 706 H I + P G +TAS DKT ++W + L+ HT + + Sbjct: 345 ----GHEGEISKVAFNPQ--GTRLITASSDKTCRLW----DCDTGECLQVLEGHTDEIFS 394 Query: 707 ISIHDSMIREKILISVGLEN 726 + + +I+ +N Sbjct: 395 CAFN---YEGDFIITGSKDN 411 Score = 97.3 bits (240), Expect = 2e-20, Method: Composition-based stats. Identities = 27/125 (21%), Positives = 52/125 (41%), Gaps = 8/125 (6%) Query: 15 NKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFM 74 ++ V+ K+V+ A + L+ TL GHE E++ V F P + Sbjct: 306 DEVLDVAFDAAGTKMVSASADGSARLY---HTLTGVCQHTLVGHEGEISKVAFNPQGTRL 362 Query: 75 VSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSAL--PSLISVGCADGTISIWRQN 132 ++AS D ++W +C+Q ++ ++ I + + I G D T IW+ Sbjct: 363 ITASSDKTCRLWDCDTG---ECLQVLEGHTDEIFSCAFNYEGDFIITGSKDNTCRIWKAL 419 Query: 133 IQNDE 137 + + Sbjct: 420 TASSQ 424 Score = 68.8 bits (166), Expect = 8e-12, Method: Composition-based stats. Identities = 25/184 (13%), Positives = 58/184 (31%), Gaps = 21/184 (11%) Query: 543 QRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPAL 602 Q+H + + L H +T + + + ++++T E L Sbjct: 79 QQHHSFTLFKVLRAHILPLTNCAFNKSGDRFITGSY-----DRTCKVWNTFTG-EEVFTL 132 Query: 603 PFHSLTITRLKF-SKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADW 661 H + + F + G +++ D+ LW+ + L K H I Sbjct: 133 EGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTL-----KGHQTEI--VCL 185 Query: 662 APLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILIS 721 + + T S D T K+W + H + ++ + ++++ Sbjct: 186 SFNPQSTIIATGSMDNTAKLWDVE----TGQERATLAGHRAEIVSLGFN---TGGDLIVT 238 Query: 722 VGLE 725 + Sbjct: 239 GSFD 242 Score = 50.3 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 26/125 (20%), Positives = 50/125 (40%), Gaps = 13/125 (10%) Query: 602 LPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADW 661 L H L +T F+K G ++ DR +W + F L + H +++ + Sbjct: 90 LRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTL-----EGHKNVVYAIAF 144 Query: 662 APLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILIS 721 +G+ VT S DKT K+W + + H + +S + + I+ + Sbjct: 145 N-NPYGDKIVTGSFDKTCKLW----DAYTGQLYYTLKGHQTEIVCLSFNP---QSTIIAT 196 Query: 722 VGLEN 726 ++N Sbjct: 197 GSMDN 201 >1VYH-C nrPDB Length = 410 Score = 200 bits (508), Expect = 2e-51, Method: Composition-based stats. Identities = 59/318 (18%), Positives = 120/318 (37%), Gaps = 66/318 (20%) Query: 8 EAIFIGA-NKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVR 66 E G + +S H K + + A TI LWD T+ GH+ V+ V Sbjct: 143 ERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDF---QGFECIRTMHGHDHNVSSVS 199 Query: 67 FVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSA--LPSLISVGCADG 124 +P+ D +VSAS D +K+W+ C++T + + + + +LI+ D Sbjct: 200 IMPNGDHIVSASRDKTIKMWEVQTGY---CVKTFTGHREWVRMVRPNQDGTLIASCSNDQ 256 Query: 125 TISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVE------------EKKYLLAIGG 172 T+ +W + + L + + + S S + +LL+ G Sbjct: 257 TVRVWVVATKECKAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLS-GS 315 Query: 173 TNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRL 232 + + + + + L GH++WV+ + F G + S + D+ +R+ Sbjct: 316 RDKTIKMW-------DVSTGMCLMTLVGHDNWVRGVLFH----SGGKFILSCADDKTLRV 364 Query: 233 WRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHES 292 W + NK+ ++ H+ +++SL +H++ Sbjct: 365 WDYK-------------------NKRCMKTLN--------------AHEHFVTSLDFHKT 391 Query: 293 RLQLLAATADTSLMVWEP 310 ++ + D ++ VWE Sbjct: 392 APYVVTGSVDQTVKVWEC 409 Score = 155 bits (390), Expect = 1e-37, Method: Composition-based stats. Identities = 63/377 (16%), Positives = 128/377 (33%), Gaps = 65/377 (17%) Query: 42 DPIEPNNKGVYA-TLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTI 100 DP E + L GH + VT V F P MVSASED +K+W + +T+ Sbjct: 90 DPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFE---RTL 146 Query: 101 QHYSKTIVALSAL--PSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSL 158 + ++ ++ +S L++ AD TI +W F S+ Sbjct: 147 KGHTDSVQDISFDHSGKLLASCSADMTIKLWDF----QGFECIRTMHGHDHNVS----SV 198 Query: 159 SKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGD 218 S + ++++ + ++ V GH +WV+ + Sbjct: 199 SIMPNGDHIVSA--------SRDKTIKMWEVQTGYCVKTFTGHREWVRMVR----PNQDG 246 Query: 219 YLLCSGSQDRYIRLWRIRIND---LIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEA 275 L+ S S D+ +R+W + + + + + ++ Y + E Sbjct: 247 TLIASCSNDQTVRVWVVATKECKAELREHRHVVECISWAPESSY-----SSISEATGSET 301 Query: 276 LIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTAT 335 G + LL+ + D ++ +W+ + Sbjct: 302 KKSG-----------KPGPFLLSGSRDKTIKMWDVSTGMCLMTLV--------------- 335 Query: 336 GSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSP 395 + + F H F L+ + R+W K+ ++ VT + + Sbjct: 336 -GHDNWVRGVLF-HSGGKFILSCADDKTLRVWDYKNKRCMK---TLNAHEHFVTSLDFHK 390 Query: 396 SGEYLLATSLDQTTRLF 412 + Y++ S+DQT +++ Sbjct: 391 TAPYVVTGSVDQTVKVW 407 Score = 123 bits (307), Expect = 4e-28, Method: Composition-based stats. Identities = 52/355 (14%), Positives = 124/355 (34%), Gaps = 53/355 (14%) Query: 127 SIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSD 186 W H + + F+P+ ++ + + + + Sbjct: 92 KEWIPRPPEKYALSGHRSPVTRVIFHPVFS----------VMVSASEDATIKVWDY---- 137 Query: 187 SGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLID---D 243 E L+GH D V+ ++F H LL S S D I+LW + + I Sbjct: 138 ---ETGDFERTLKGHTDSVQDISFDHS----GKLLASCSADMTIKLWDFQGFECIRTMHG 190 Query: 244 SEEDSKKLTLLSNKQYKFQI--DDELRVGINFEAL----IMGHDDWISSLQWHESRLQLL 297 + + ++++ N + D +++ GH +W+ ++ ++ + Sbjct: 191 HDHNVSSVSIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIA 250 Query: 298 AATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERM----- 352 + + D ++ VW LR + S A SS S + + Sbjct: 251 SCSNDQTVRVWVVATKECK--AELREHRHVVECISWAPESSYSSISEATGSETKKSGKPG 308 Query: 353 DFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLF 412 F L+ + + +MW + + + G V + + G+++L+ + D+T R Sbjct: 309 PFLLSGSRDKTIKMWDVSTGMCL---MTLVGHDNWVRGVLFHSGGKFILSCADDKTLR-- 363 Query: 413 APWIYDASGRKREIATWHEFSRPQIHGYDMICVE-TVTDTRFVSGGDEKILRSFD 466 ++D ++ + H + + ++ T V+G ++ ++ ++ Sbjct: 364 ---VWDYKNKR----CMKTLN---AHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408 Score = 83.8 bits (205), Expect = 2e-16, Method: Composition-based stats. Identities = 45/286 (15%), Positives = 85/286 (29%), Gaps = 66/286 (23%) Query: 198 LEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNK 257 L GH V + F + ++ S S+D I++W Sbjct: 104 LSGHRSPVTRVIFHPVFS----VMVSASEDATIKVWDYETG------------------- 140 Query: 258 QYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIW 317 +FE + GH D + + + S L + +AD ++ +W+ I Sbjct: 141 --------------DFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECI- 185 Query: 318 VCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQ 377 T G S D ++ + + +MW + Sbjct: 186 --------------RTMHGHDHNVSSVSIM--PNGDHIVSASRDKTIKMWEVQTGYCVK- 228 Query: 378 RLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQI 437 +G + V + + G + + S DQT R++ + RE E Sbjct: 229 --TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHRHVVECISWAP 286 Query: 438 HGYDMICVETVTD---------TRFVSGGDEKILRSFDLPKGVAGM 474 E +SG +K ++ +D+ G+ M Sbjct: 287 ESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLM 332 Score = 81.5 bits (199), Expect = 1e-15, Method: Composition-based stats. Identities = 59/285 (20%), Positives = 108/285 (37%), Gaps = 37/285 (12%) Query: 514 EEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLI 573 E E N+ + T L + ++ + R PE L GH +T + P ++ Sbjct: 67 ELESKLNEAKEEFTSGGPLGQKRDPKEWIPRP---PEKYALSGHRSPVTRVIFHPVFSVM 123 Query: 574 ASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALW 633 SA ++A I+++ E + + L H+ ++ + F GK L S D LW Sbjct: 124 VSAS-----EDATIKVWDYETG-DFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLW 177 Query: 634 ERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYV 693 + FE + + + + G+ V+ASRDKT+K+W Q Y Sbjct: 178 DFQ----GFECIRTMHGHDHNV---SSVSIMPNGDHIVSASRDKTIKMWEVQ----TGYC 226 Query: 694 LEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLG----------KFELIT 743 ++ H + V + + ++ S + T E I+ Sbjct: 227 VKTFTGHREWVRMVRPNQDGT---LIASCSNDQTVRVWVVATKECKAELREHRHVVECIS 283 Query: 744 QLNEDITPADKITRLRWSHLKRNGK--LFLGVGSSDLSTRIYSLA 786 E + I+ S K++GK FL GS D + +++ ++ Sbjct: 284 WAPE--SSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVS 326 Score = 77.6 bits (189), Expect = 2e-14, Method: Composition-based stats. Identities = 31/173 (17%), Positives = 66/173 (38%), Gaps = 23/173 (13%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 + ++GH ++ + I P+ I SA R I+++ + +K H + Sbjct: 185 IRTMHGHDHNVSSVSIMPNGDHIVSASRDKT-----IKMWEVQTGYCVK-TFTGHREWVR 238 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPH-TRIIWDADWAPL----- 664 ++ ++DG + S D+ +W ++ ELR ++ ++ + Sbjct: 239 MVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHRHVVECISWAPESSYSSISEATG 298 Query: 665 -------EFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIH 710 + G ++ SRDKT+K+W + L + H V + H Sbjct: 299 SETKKSGKPGPFLLSGSRDKTIKMWDV----STGMCLMTLVGHDNWVRGVLFH 347 Score = 72.6 bits (176), Expect = 6e-13, Method: Composition-based stats. Identities = 59/338 (17%), Positives = 115/338 (34%), Gaps = 45/338 (13%) Query: 349 HERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQT 408 H ++ + + ++W + D + G T V DI++ SG+ L + S D T Sbjct: 117 HPVFSVMVSASEDATIKVWDYETG---DFERTLKGHTDSVQDISFDHSGKLLASCSADMT 173 Query: 409 TRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETV-TDTRFVSGGDEKILRSFDL 467 +L +D G I T H H +++ V + VS +K ++ +++ Sbjct: 174 IKL-----WDFQG-FECIRTMH------GHDHNVSSVSIMPNGDHIVSASRDKTIKMWEV 221 Query: 468 PKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDIT 527 G ++ F G + + P+ + SN +E + +E + Sbjct: 222 QTGYC--VKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHRHVV 279 Query: 528 DPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVI 587 + + + + G + + S R I Sbjct: 280 E----------CISWAPESSYSSISEATGSETK----KSGKPGPFLLSGSRDKT-----I 320 Query: 588 RIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFK 647 +++ + + L H + + F GKF+LS D+ +W+ + K Sbjct: 321 KMWDVSTGMCL-MTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCM-----K 374 Query: 648 NEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQ 685 H + D + VT S D+TVKVW + Sbjct: 375 TLNAHEHFVTSLD--FHKTAPYVVTGSVDQTVKVWECR 410 Score = 65.7 bits (158), Expect = 7e-11, Method: Composition-based stats. Identities = 34/196 (17%), Positives = 68/196 (34%), Gaps = 40/196 (20%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 V+ GH + + + D LIAS V+ V+ E K L H + Sbjct: 227 VKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATK------ECKAELREHRHVVE 280 Query: 611 RLKFSKD--------------------GKFLLSVCRDRKWALWERNMEDNTFELRFKNEK 650 + ++ + G FLLS RD+ +W+ + L + Sbjct: 281 CISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDN- 339 Query: 651 PHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIH 710 W G ++ + DKT++VW ++ + ++ H VT++ H Sbjct: 340 ------WVRGVLFHSGGKFILSCADDKTLRVWDYKNKRC----MKTLNAHEHFVTSLDFH 389 Query: 711 DSMIREKILISVGLEN 726 + +++ ++ Sbjct: 390 KTAPY---VVTGSVDQ 402 >4V8M-A7 nrPDB Length = 318 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 81/382 (21%), Positives = 136/382 (35%), Gaps = 87/382 (22%) Query: 269 VGINFEALIMGHDDWISSL---QWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGE 325 + + +E + GH W++SL Q E+ ++++ + D +L+ W P+ CS L + Sbjct: 1 MAVAYEGQLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPD 60 Query: 326 MSSKGAST-----ATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLG 380 +G S A ++G F + H + L NG+ C + Sbjct: 61 RRLEGHSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQ--------------CQYKF- 105 Query: 381 ISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGY 440 G TKDV +A+SP +++ D R +++ G H SR H Sbjct: 106 -LGHTKDVLSVAFSPDNRQIVSGGRDNALR-----VWNVKGE-----CMHTLSR-GAHTD 153 Query: 441 DMICVE---TVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPV 497 + CV ++ VSGG + +++ +DL G + V + + S TV Sbjct: 154 WVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATG------RLV-TDLKGHTNYVTSVTVSP 206 Query: 498 LGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGH 557 G + + D G D+T +L E Sbjct: 207 DGSLCASSDKD----------GVARLWDLTKGEALSEMAA-------------------- 236 Query: 558 GFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLT------ITR 611 G I + SP++ + +A IRIF EN I P H + Sbjct: 237 GAPINQICFSPNRYWMCAATEKG------IRIFDLENKDIIVELAPEHQGSKKIVPECVS 290 Query: 612 LKFSKDGKFLLSVCRDRKWALW 633 + +S DG L S D +W Sbjct: 291 IAWSADGSTLYSGYTDNVIRVW 312 Score = 175 bits (444), Expect = 5e-44, Method: Composition-based stats. Identities = 59/311 (18%), Positives = 115/311 (36%), Gaps = 42/311 (13%) Query: 25 KVKKIVAFGAGKTIALW--DPIEPNNKGVY----ATLKGHEAEVTCVRFVPDSDFMVSAS 78 K+V+ KT+ W +P +++ Y L+GH A V+ V + +F VSAS Sbjct: 27 TATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSAFVSDVALSNNGNFAVSAS 86 Query: 79 EDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS--LISVGCADGTISIWRQNIQND 136 DH +++W + QC ++K +++++ P I G D + +W + Sbjct: 87 WDHSLRLWNLQNG---QCQYKFLGHTKDVLSVAFSPDNRQIVSGGRDNALRVWNVKGE-- 141 Query: 137 EFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVA 196 H + + C+ S + +++ G N ++ + R+V Sbjct: 142 ---CMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDN--------LVKVWDLATGRLVT 190 Query: 197 ELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDD--SEEDSKKLTLL 254 +L+GH ++V S+ P L S +D RLW + + + + + ++ Sbjct: 191 DLKGHTNYVTSVTVS----PDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPINQICFS 246 Query: 255 SNKQYKFQIDD------ELRVGINFEALIMGHDD------WISSLQWHESRLQLLAATAD 302 N+ + + +L L H S+ W L + D Sbjct: 247 PNRYWMCAATEKGIRIFDLENKDIIVELAPEHQGSKKIVPECVSIAWSADGSTLYSGYTD 306 Query: 303 TSLMVWEPDET 313 + VW E Sbjct: 307 NVIRVWGVSEN 317 Score = 116 bits (291), Expect = 3e-26, Method: Composition-based stats. Identities = 62/377 (16%), Positives = 120/377 (31%), Gaps = 90/377 (23%) Query: 55 LKGHEAEVTCVRFVPDSD----FMVSASEDHHVKIWKFT-DYSHLQCI-----QTIQHYS 104 L GH VT + P + +VS S D + W D +C + ++ +S Sbjct: 9 LTGHRGWVTSLA-CPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHS 67 Query: 105 KTI--VALSALPSLISVGCADGTISIWRQ-NIQNDEFGLAHEFTIKKGFFYPLCLSLSKV 161 + VALS + D ++ +W N Q L H + LS++ Sbjct: 68 AFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDV---------LSVAFS 118 Query: 162 EEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELE--GHEDWVKSLAFRHQETPGDY 219 + + +++ GG + + + + + L H DWV + F + Sbjct: 119 PDNRQIVS-GGRDNALRVWNVK--------GECMHTLSRGAHTDWVSCVRFSP--SLDAP 167 Query: 220 LLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMG 279 ++ SG D +++W + L+ D + G Sbjct: 168 VIVSGGWDNLVKVWDLATGRLVTD---------------------------------LKG 194 Query: 280 HDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSG 339 H ++++S+ ++ D +W+ + + + + Sbjct: 195 HTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPINQICFSP------N 248 Query: 340 GFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATK---DVTDIAWSPS 396 +W C F L N +II + G+ K + IAWS Sbjct: 249 RYWMCAATEKGIRIFDLEN------------KDIIVELAPEHQGSKKIVPECVSIAWSAD 296 Query: 397 GEYLLATSLDQTTRLFA 413 G L + D R++ Sbjct: 297 GSTLYSGYTDNVIRVWG 313 Score = 100 bits (249), Expect = 2e-21, Method: Composition-based stats. Identities = 44/237 (18%), Positives = 81/237 (34%), Gaps = 38/237 (16%) Query: 195 VAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW----RIRIND--------LID 242 +L GH WV SLA Q + S S+D+ + W ++ ++ Sbjct: 6 EGQLTGHRGWVTSLA-CPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLE 64 Query: 243 DSEEDSKKLTLLSNKQYKFQI--DDELRVGINFEAL----IMGHDDWISSLQWHESRLQL 296 + L +N + D LR+ +GH + S+ + Q+ Sbjct: 65 GHSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQI 124 Query: 297 LAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHER-MDFF 355 ++ D +L VW GE + + G+ + SC+ F+ Sbjct: 125 VSGGRDNALRVWNVK------------GECM---HTLSRGAHTDWVSCVRFSPSLDAPVI 169 Query: 356 LTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLF 412 ++ G ++W + + G T VT + SP G ++ D RL+ Sbjct: 170 VSGGWDNLVKVWDLATGRLVT---DLKGHTNYVTSVTVSPDGSLCASSDKDGVARLW 223 Score = 85.7 bits (210), Expect = 6e-17, Method: Composition-based stats. Identities = 35/181 (19%), Positives = 64/181 (35%), Gaps = 19/181 (10%) Query: 553 KLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRI---FSTENWLEIKPA----LPFH 605 +L GH +T L P A+ S + ++ + L H Sbjct: 8 QLTGHRGWVTSLAC-PQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGH 66 Query: 606 SLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLE 665 S ++ + S +G F +S D LW ++ HT+ + ++P Sbjct: 67 SAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFL-----GHTKDVLSVAFSP-- 119 Query: 666 FGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLE 725 V+ RD ++VW + E A HT V+ + S+ +++S G + Sbjct: 120 DNRQIVSGGRDNALRVWNVKGECMHTLSRGA---HTDWVSCVRFSPSLDAP-VIVSGGWD 175 Query: 726 N 726 N Sbjct: 176 N 176 Score = 68.0 bits (164), Expect = 2e-11, Method: Composition-based stats. Identities = 34/160 (21%), Positives = 64/160 (40%), Gaps = 14/160 (8%) Query: 552 EKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITR 611 +L GH ++ + +S + SA ++ +R+++ +N L H+ + Sbjct: 61 RRLEGHSAFVSDVALSNNGNFAVSASWDHS-----LRLWNLQNGQCQYKFL-GHTKDVLS 114 Query: 612 LKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFV 671 + FS D + ++S RD +W E R HT + ++P V V Sbjct: 115 VAFSPDNRQIVSGGRDNALRVWNVKGECMHTLSR----GAHTDWVSCVRFSPSLDAPVIV 170 Query: 672 TASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHD 711 + D VKVW A ++ HT VT++++ Sbjct: 171 SGGWDNLVKVWDL----ATGRLVTDLKGHTNYVTSVTVSP 206 Score = 62.2 bits (149), Expect = 8e-10, Method: Composition-based stats. Identities = 56/341 (16%), Positives = 117/341 (34%), Gaps = 60/341 (17%) Query: 355 FLTNGKTGSWRMWATK-DNIICDQRLGIS-----GATKDVTDIAWSPSGEYLLATSLDQT 408 ++ + + W D + G+ G + V+D+A S +G + ++ S D + Sbjct: 31 VVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSAFVSDVALSNNGNFAVSASWDHS 90 Query: 409 TRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVE-TVTDTRFVSGGDEKILRSFDL 467 RL+ + ++F H D++ V + + + VSGG + LR +++ Sbjct: 91 LRLW---------NLQNGQCQYKFL---GHTKDVLSVAFSPDNRQIVSGGRDNALRVWNV 138 Query: 468 PKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDIT 527 L + + S PV+ GG + Sbjct: 139 KGECMHTLSRGAHTDWVSCVRFSPSLDAPVI-----------------VSGGWDNLVKVW 181 Query: 528 DPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVI 587 D L L + L GH +T + +SPD L AS+ + + Sbjct: 182 D-------------LATGRLVTD---LKGHTNYVTSVTVSPDGSLCASSDKDGVARLW-- 223 Query: 588 RIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFK 647 + E E+ P I ++ FS + ++ + ++ +++ +D EL + Sbjct: 224 DLTKGEALSEMAAGAP-----INQICFSPN-RYWMCAATEKGIRIFDLENKDIIVELAPE 277 Query: 648 NEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEP 688 ++ + A G+ + D ++VW + Sbjct: 278 HQGSKKIVPECVSIAWSADGSTLYSGYTDNVIRVWGVSENA 318 Score = 52.6 bits (124), Expect = 6e-07, Method: Composition-based stats. Identities = 33/195 (16%), Positives = 70/195 (35%), Gaps = 29/195 (14%) Query: 556 GHGFEITCLDISP--DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLK 613 H ++C+ SP D +I S N V+ + L H+ +T + Sbjct: 150 AHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGRLVTD------LKGHTNYVTSVT 203 Query: 614 FSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTA 673 S DG S +D LW+ + E+ I ++P + ++ A Sbjct: 204 VSPDGSLCASSDKDGVARLWDLTKGEALSEM------AAGAPINQICFSPNRY---WMCA 254 Query: 674 SRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYS 733 + +K ++++ + + D ++E + +H I + + +G LYS Sbjct: 255 ATEKGIRIFDLENK---DIIVELAPEHQ--------GSKKIVPECVSIAWSADGS-TLYS 302 Query: 734 YTLGKFELITQLNED 748 + ++E+ Sbjct: 303 GYTDNVIRVWGVSEN 317 >5NNZ-B nrPDB Length = 415 Score = 193 bits (489), Expect = 3e-49, Method: Composition-based stats. Identities = 70/365 (19%), Positives = 123/365 (33%), Gaps = 57/365 (15%) Query: 16 KQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRF-VPDSDFM 74 T V+ + +T LWD TL+GH V + F P D + Sbjct: 94 PLTNVALNKSGSCFITGSYDRTCKLWDTASGEE---LNTLEGHRNVVYAIAFNNPYGDKI 150 Query: 75 VSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS--LISVGCADGTISIWR-Q 131 + S D K+W C T + ++ IV LS P L++ G D T +W Q Sbjct: 151 ATGSFDKTCKLWSVETGK---CYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ 207 Query: 132 NIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEK 191 N + H +SLS ++ G + V + + Sbjct: 208 NGEEVYTLRGH---------SAEIISLSFNTSGDRII-TGSFDHTVVVW-------DADT 250 Query: 192 CRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI---RINDLIDDSEEDS 248 R V L GH + S +F L+ +GS D+ +LW + + +++ Sbjct: 251 GRKVNILIGHCAEISSASFNW----DCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEI 306 Query: 249 KKLTLLSNKQYKFQIDDELRVGI------NFEALIMGHDDWISSLQWHESRLQLLAATAD 302 + + I A + GH+ IS + ++ LL ++D Sbjct: 307 LDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSD 366 Query: 303 TSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTG 362 + +W+ + V G + +SC F ++ + +T K Sbjct: 367 KTARIWDAQTGQCLQVLE---------------GHTDEIFSCA-FNYKG-NIVITGSKDN 409 Query: 363 SWRMW 367 + R+W Sbjct: 410 TCRIW 414 Score = 129 bits (323), Expect = 5e-30, Method: Composition-based stats. Identities = 45/221 (20%), Positives = 82/221 (37%), Gaps = 28/221 (12%) Query: 16 KQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMV 75 + +S +I+ T+ +WD + L GH AE++ F D ++ Sbjct: 221 EIISLSFNTSGDRIITGSFDHTVVVWDA---DTGRKVNILIGHCAEISSASFNWDCSLIL 277 Query: 76 SASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIV--ALSALPSLISVGCADGTISIWRQNI 133 + S D K+W T+ C+ T+ + I+ LI+ ADGT I+ Sbjct: 278 TGSMDKTCKLWDATNGK---CVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAAT 334 Query: 134 QNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCR 193 + + +G +S + +LL + + Sbjct: 335 RK----CIAKLEGHEG----EISKISFNPQGNHLLTGSSDK--------TARIWDAQTGQ 378 Query: 194 VVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWR 234 + LEGH D + S AF ++ ++ +GS+D R+WR Sbjct: 379 CLQVLEGHTDEIFSCAFNYK----GNIVITGSKDNTCRIWR 415 Score = 127 bits (318), Expect = 2e-29, Method: Composition-based stats. Identities = 63/385 (16%), Positives = 123/385 (31%), Gaps = 93/385 (24%) Query: 92 SHLQCIQTIQHYSKTI--VALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKG 149 + ++ + + VAL+ S G D T +W + L + Sbjct: 80 HTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYA 139 Query: 150 FFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLA 209 + + +K +A G + + S +E + GH + L+ Sbjct: 140 IAFN-----NPYGDK---IATGSFDKTCKLWS-------VETGKCYHTFRGHTAEIVCLS 184 Query: 210 FRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRV 269 F Q T L+ +GS D +LW I+ + + Sbjct: 185 FNPQST----LVATGSMDTTAKLWDIQNGEEV---------------------------- 212 Query: 270 GINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSK 329 + GH I SL ++ S +++ + D +++VW+ D + + Sbjct: 213 -----YTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNI---------LI 258 Query: 330 GASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVT 389 G S+ W C LT + ++W + ++G ++ Sbjct: 259 GHCAEISSASFNWDCS--------LILTGSMDKTCKLWDATNGKCVA---TLTGHDDEIL 307 Query: 390 DIAWSPSGEYLLATSLDQTTRLFAPW----IYDASGRKREIATWHEFSRPQIHGYDMICV 445 D + +G+ + S D T R+F+ I G + EI+ F+ H Sbjct: 308 DSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKI-SFNPQGNH------- 359 Query: 446 ETVTDTRFVSGGDEKILRSFDLPKG 470 ++G +K R +D G Sbjct: 360 -------LLTGSSDKTARIWDAQTG 377 Score = 85.0 bits (208), Expect = 1e-16, Method: Composition-based stats. Identities = 69/375 (18%), Positives = 128/375 (34%), Gaps = 75/375 (20%) Query: 355 FLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWS-PSGEYLLATSLDQTTRLFA 413 F+T + ++W T + + G V IA++ P G+ + S D+T +L++ Sbjct: 107 FITGSYDRTCKLWDTASGEELN---TLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWS 163 Query: 414 PWIYDASGRKREIATWHEFSRPQIHGYDMICVE-TVTDTRFVSGGDEKILRSFDLPKGVA 472 +H F + H +++C+ T +G + + +D+ G Sbjct: 164 ---------VETGKCYHTF---RGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNG-- 209 Query: 473 GMLQKFVGIQFEEKSEMPDSATVPVLGLS-NKAGEDDANEDDEEEEGGNKETPDITDPLS 531 E+ + ++ LS N +G D G T + D + Sbjct: 210 ------------EEVYTLRGHSAEIISLSFNTSG-------DRIITGSFDHTVVVWDADT 250 Query: 532 LLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFS 591 +V L GH EI+ + D LI + + +++ Sbjct: 251 ----------------GRKVNILIGHCAEISSASFNWDCSLILTGS-----MDKTCKLWD 289 Query: 592 TENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKP 651 N + L H I F GK + + D ++ T + K E Sbjct: 290 ATNGKCV-ATLTGHDDEILDSCFDYTGKLIATASADGTARIFSA----ATRKCIAKLE-G 343 Query: 652 HTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHD 711 H I + P GN +T S DKT ++W Q L+ HT + + + + Sbjct: 344 HEGEISKISFNPQ--GNHLLTGSSDKTARIWDAQTGQC----LQVLEGHTDEIFSCAFN- 396 Query: 712 SMIREKILISVGLEN 726 + I+I+ +N Sbjct: 397 --YKGNIVITGSKDN 409 Score = 78.0 bits (190), Expect = 1e-14, Method: Composition-based stats. Identities = 50/238 (21%), Positives = 83/238 (34%), Gaps = 31/238 (13%) Query: 550 EVEKLYGHGFEITCLDIS-PDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLT 608 E+ L GH + + + P IA+ +++S E H+ Sbjct: 126 ELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTC-----KLWSVETGKC-YHTFRGHTAE 179 Query: 609 ITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGN 668 I L F+ + + D LW+ + + LR H+ I + G+ Sbjct: 180 IVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR-----GHSAEIIS--LSFNTSGD 232 Query: 669 VFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGE 728 +T S D TV VW + I H +++ S + + LI G + Sbjct: 233 RIITGSFDHTVVVWDADTGRKVN----ILIGHCAEISSASFN----WDCSLILTGSMDKT 284 Query: 729 IYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYSLA 786 L+ T GK +T D + S GKL + S+D + RI+S A Sbjct: 285 CKLWDATNGKCVAT------LTGHDD--EILDSCFDYTGKL-IATASADGTARIFSAA 333 Score = 68.8 bits (166), Expect = 1e-11, Method: Composition-based stats. Identities = 37/133 (27%), Positives = 54/133 (40%), Gaps = 13/133 (9%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 V L GH EI KLIA+A RIFS I L H I+ Sbjct: 296 VATLTGHDDEILDSCFDYTGKLIATASADGTA-----RIFSAATRKCI-AKLEGHEGEIS 349 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVF 670 ++ F+ G LL+ D+ +W+ + + HT I+ A GN+ Sbjct: 350 KISFNPQGNHLLTGSSDKTARIWDAQTGQCL-----QVLEGHTDEIFSC--AFNYKGNIV 402 Query: 671 VTASRDKTVKVWR 683 +T S+D T ++WR Sbjct: 403 ITGSKDNTCRIWR 415 Score = 53.0 bits (125), Expect = 5e-07, Method: Composition-based stats. Identities = 32/173 (18%), Positives = 60/173 (34%), Gaps = 28/173 (16%) Query: 602 LPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADW 661 L H L +T + +K G ++ DR LW+ + L + + Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNN--- 144 Query: 662 APLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASI-KHTKAVTAISIHDSMIREKILI 720 +G+ T S DKT K+W + + HT + +S + + ++ Sbjct: 145 ---PYGDKIATGSFDKTCKLWSV-----ETGKCYHTFRGHTAEIVCLSFNP---QSTLVA 193 Query: 721 SVGLE---------NGE--IYLYSYTLGKFELITQLNED--ITPADKITRLRW 760 + ++ NGE L ++ L + D IT + T + W Sbjct: 194 TGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW 246 >4BTS-AR nrPDB Length = 343 Score = 184 bits (466), Expect = 1e-46, Method: Composition-based stats. Identities = 53/243 (21%), Positives = 97/243 (39%), Gaps = 47/243 (19%) Query: 198 LEGHEDWVKSL--AFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLT--- 252 LEGH DWV S+ F +E +L SGS+D+ + +W++ + K LT Sbjct: 17 LEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHN 76 Query: 253 -----LLSNKQYKFQIDD---------ELRVGINFEALIMGHDDWISSLQWHESRLQLLA 298 L +++ F I +LR G ++ + GH + S+ + Q+L+ Sbjct: 77 HFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFV-GHQSEVYSVAFSPDNRQILS 135 Query: 299 ATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFT---------H 349 A A+ + +W LGE K +S + + SC+ ++ Sbjct: 136 AGAEREIKLWNI------------LGEC--KFSSAEKENHSDWVSCVRYSPIMKSANKVQ 181 Query: 350 ERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTT 409 +F + G G ++W T I R +V ++ SP+G+Y+ D+ Sbjct: 182 PFAPYFASVGWDGRLKVWNTNFQI----RYTFKAHESNVNHLSISPNGKYIATGGKDKKL 237 Query: 410 RLF 412 ++ Sbjct: 238 LIW 240 Score = 125 bits (313), Expect = 9e-29, Method: Composition-based stats. Identities = 51/320 (15%), Positives = 107/320 (33%), Gaps = 59/320 (18%) Query: 7 PEAIFIGANK-QTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCV 65 P G N + ++ + ++ KT+ LWD Y GH++EV V Sbjct: 68 PHKALTGHNHFVSDLALSQENCFAISSSWDKTLRLWDL---RTGTTYKRFVGHQSEVYSV 124 Query: 66 RFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP----------- 114 F PD+ ++SA + +K+W + +++S + + P Sbjct: 125 AFSPDNRQILSAGAEREIKLWNILGECKFSSAEK-ENHSDWVSCVRYSPIMKSANKVQPF 183 Query: 115 -SLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGT 173 + DG + +W N Q AHE + LS KY +A GG Sbjct: 184 APYFASVGWDGRLKVWNTNFQIRYTFKAHESNVNH---------LSISPNGKY-IATGGK 233 Query: 174 NVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW 233 + + I + + + + +AF + + G+ D+ ++++ Sbjct: 234 DKKLLIWDILNLTYPQREFDAGST-------INQIAFNPKL----QWVAVGT-DQGVKIF 281 Query: 234 RIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESR 293 + +++ +T ++ G + +SL W+ Sbjct: 282 NLMTQSKAPVCTIEAEPITKAEGQK--------------------GKNPQCTSLAWNALG 321 Query: 294 LQLLAATADTSLMVWEPDET 313 +L A D + + + + Sbjct: 322 KKLFAGFTDGVIRTFSFETS 341 Score = 107 bits (267), Expect = 2e-23, Method: Composition-based stats. Identities = 57/321 (17%), Positives = 105/321 (32%), Gaps = 49/321 (15%) Query: 55 LKGHEAEVTCVR--FVP----DSDFMVSASEDHHVKIWKF----TDYSHLQCIQTIQHYS 104 L+GH VT + F DS ++S S D V IWK + + + ++ Sbjct: 17 LEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHN 76 Query: 105 KTI--VALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVE 162 + +ALS D T+ +W S++ Sbjct: 77 HFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFV--------GHQSEVYSVAFSP 128 Query: 163 EKKYLLAIGGTNVNVFIASFILSDSGIEKCR-VVAELEGHEDWVKSLAFRH------QET 215 + + +L+ G + + + + +C+ AE E H DWV + + + Sbjct: 129 DNRQILSAGAE-REIKLWNI------LGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQ 181 Query: 216 PGDYLLCSGSQDRYIRLW--RIRINDLIDDSEEDSKKLTLLSNKQYK--------FQIDD 265 P S D +++W +I E + L++ N +Y I D Sbjct: 182 PFAPYFASVGWDGRLKVWNTNFQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKLLIWD 241 Query: 266 ELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGE 325 L + G I+ + ++ LQ +A D + ++ S VC+ + Sbjct: 242 ILNLTYPQREFDAG--STINQIAFNPK-LQWVAVGTDQGVKIFNLMTQSKAPVCT--IEA 296 Query: 326 MSSKGASTATGSSGGFWSCLW 346 A G + S W Sbjct: 297 EPITKAEGQKGKNPQCTSLAW 317 Score = 99.6 bits (246), Expect = 5e-21, Method: Composition-based stats. Identities = 36/223 (16%), Positives = 80/223 (35%), Gaps = 40/223 (17%) Query: 261 FQIDDELRVGINFEALIMGHDDWISSL------QWHESRLQLLAATADTSLMVWEPDETS 314 + L + + ++ GH DW++S+ + +E L++ + D ++M+W+ E Sbjct: 1 MADNSSLDIQVVKRGILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEE 60 Query: 315 GIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNII 374 + TG + F S L + E F +++ + R+W + Sbjct: 61 --QNGYFGIP------HKALTGHN-HFVSDLALSQENC-FAISSSWDKTLRLWDLRTGTT 110 Query: 375 CDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSR 434 + G +V +A+SP +L+ ++ +L ++ G + Sbjct: 111 YKR---FVGHQSEVYSVAFSPDNRQILSAGAEREIKL-----WNILGE-----CKFSSAE 157 Query: 435 PQIHGYDMICVETVT-----------DTRFVSGGDEKILRSFD 466 + H + CV F S G + L+ ++ Sbjct: 158 KENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWN 200 Score = 81.5 bits (199), Expect = 1e-15, Method: Composition-based stats. Identities = 41/246 (16%), Positives = 80/246 (32%), Gaps = 32/246 (13%) Query: 553 KLYGHGFEITCLDI------SPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALP--- 603 L GH +T + + D ++ S R V+ E +P Sbjct: 16 ILEGHSDWVTSIVAGFSQKENEDSPVLISGSRD----KTVMIWKLYEEEQNGYFGIPHKA 71 Query: 604 --FHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADW 661 H+ ++ L S++ F +S D+ LW+ +K H ++ + Sbjct: 72 LTGHNHFVSDLALSQENCFAISSSWDKTLRLWDLRTGT-----TYKRFVGHQSEVYSVAF 126 Query: 662 APLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILIS 721 +P ++A ++ +K+W E + H+ V+ + M + Sbjct: 127 SP--DNRQILSAGAEREIKLWNILGECKFSSAEKE--NHSDWVSCVRYSPIMKS-----A 177 Query: 722 VGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHL--KRNGKLFLGVGSSDLS 779 ++ Y S + N I K +HL NGK ++ G D Sbjct: 178 NKVQPFAPYFASVGWDGRLKVWNTNFQIRYTFKAHESNVNHLSISPNGK-YIATGGKDKK 236 Query: 780 TRIYSL 785 I+ + Sbjct: 237 LLIWDI 242 Score = 54.1 bits (128), Expect = 3e-07, Method: Composition-based stats. Identities = 49/287 (17%), Positives = 102/287 (35%), Gaps = 69/287 (24%) Query: 368 ATKDNIICDQRLGISGATKDVTDIAWSPSGEY------LLATSLDQTTRLFAPWIYDASG 421 + +I +R + G + VT I S + L++ S D+T ++ + + +G Sbjct: 4 NSSLDIQVVKRGILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNG 63 Query: 422 RKREIATWHEFSRPQIHGYDMICVETVTDTRF-VSGGDEKILRSFDLPKGVAGMLQKFVG 480 H + + + + F +S +K LR +DL G ++FVG Sbjct: 64 YFGIPHKALT-----GHNHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTT--YKRFVG 116 Query: 481 IQFEEKSEM--PDSATVPVLG------LSNKAGEDDANEDDEEEEGGNKETPDITDPLSL 532 Q E S PD+ + G L N GE + ++E Sbjct: 117 HQSEVYSVAFSPDNRQILSAGAEREIKLWNILGECKFSSAEKEN---------------- 160 Query: 533 LECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISP-----DQKLIASACRSNNVQNAVI 587 H ++C+ SP ++ + ++ + + Sbjct: 161 ------------------------HSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRL 196 Query: 588 RIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWE 634 ++++T +I+ H + L S +GK++ + +D+K +W+ Sbjct: 197 KVWNT--NFQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKLLIWD 241 >3JRO-A nrPDB Length = 753 Score = 176 bits (446), Expect = 3e-44, Method: Composition-based stats. Identities = 61/272 (22%), Positives = 107/272 (39%), Gaps = 25/272 (9%) Query: 26 VKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPD--SDFMVSASEDHHV 83 K++ + KTI +++ E + TL GHE V V + + S S D V Sbjct: 21 GKRLATCSSDKTIKIFEV-EGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKV 79 Query: 84 KIWKFTDYSHLQCIQTIQHYSKTIVALSALP----SLISVGCADGTISI--WRQNIQNDE 137 IWK + Q I +S ++ ++ P L+ V +DG +S+ +++N Sbjct: 80 LIWKEENGRWSQ-IAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSP 138 Query: 138 FGL-AHEFTIKKGFFYPLCLSLSKVEEK---KYLLAIGGTNVNVFIASFILSDSGIEKCR 193 + AH + + P + GG + V I + +S + Sbjct: 139 IIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY---NSDAQTYV 195 Query: 194 VVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTL 253 + + LEGH DWV+ +A+ Y L S SQDR +W D+E+ K TL Sbjct: 196 LESTLEGHSDWVRDVAWSPTVLLRSY-LASVSQDRTCIIW-------TQDNEQGPWKKTL 247 Query: 254 LSNKQYKFQIDDELRVGINFEALIMGHDDWIS 285 L +++ + + G D+ ++ Sbjct: 248 LKEEKFPDVLWRASWSLSGNVLALSGGDNKVT 279 Score = 64.9 bits (156), Expect = 1e-10, Method: Composition-based stats. Identities = 50/229 (21%), Positives = 87/229 (37%), Gaps = 25/229 (10%) Query: 551 VEKLYGHGFEITCLD-ISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPAL-PFHSLT 608 ++ L GH + +D P I ++C + + I+ EN + A+ HS + Sbjct: 46 IDTLTGHEGPVWRVDWAHPKFGTILASCSY----DGKVLIWKEENGRWSQIAVHAVHSAS 101 Query: 609 ITRLKFSKD--GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAP--- 663 + ++++ G LL D K ++ E T + A WAP Sbjct: 102 VNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVN---SASWAPATI 158 Query: 664 --------LEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASI-KHTKAVTAISIHDSMI 714 + FVT D VK+W++ + A YVLE+++ H+ V ++ +++ Sbjct: 159 EEDGEHNGTKESRKFVTGGADNLVKIWKYNSD-AQTYVLESTLEGHSDWVRDVAWSPTVL 217 Query: 715 REKILISVGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHL 763 L SV + I T L E+ P D + R WS Sbjct: 218 LRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFP-DVLWRASWSLS 265 Score = 57.2 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 23/115 (20%), Positives = 47/115 (40%), Gaps = 8/115 (6%) Query: 575 SACRSNNVQNAVIRIFSTENWLEIKP---ALPFHSLTITRLKFSKD---GKFLLSVCRDR 628 S + +++I+ + + L HS + + +S +L SV +DR Sbjct: 170 SRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDR 229 Query: 629 KWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWR 683 +W ++ E ++ E+ ++W A W+ GNV + D V +W+ Sbjct: 230 TCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWS--LSGNVLALSGGDNKVTLWK 282 Score = 55.7 bits (132), Expect = 8e-08, Method: Composition-based stats. Identities = 33/199 (16%), Positives = 65/199 (32%), Gaps = 32/199 (16%) Query: 279 GHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSS 338 H++ I +L ++D ++ ++E + + + +L TG Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTL-------------TGHE 53 Query: 339 GGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPS-- 396 G W W + + G +W ++ + + V + W+P Sbjct: 54 GPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAV-HSASVNSVQWAPHEY 112 Query: 397 GEYLLATSLDQTTRLF--------APWIYDASGRKREIATWH--EFSRPQIHGYDMICVE 446 G LL S D + +P I DA A+W H Sbjct: 113 GPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNG------ 166 Query: 447 TVTDTRFVSGGDEKILRSF 465 T +FV+GG + +++ + Sbjct: 167 TKESRKFVTGGADNLVKIW 185 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 48/298 (16%), Positives = 101/298 (33%), Gaps = 49/298 (16%) Query: 355 FLTNGKTGSWRMWATK--DNIICDQRLGISGATKDVTDIAWS-PS-GEYLLATSLDQTTR 410 T + +++ + + + D ++G V + W+ P G L + S D Sbjct: 24 LATCSSDKTIKIFEVEGETHKLID---TLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 Query: 411 LFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVT---DTRFVSGGDEKILRSFDL 467 ++ K E W + + +H + V+ + + + Sbjct: 81 IW----------KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV--- 127 Query: 468 PKGVAGMLQKFVGIQFEEK-SEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDI 526 ++F+E + P +G+ N A A +++ E G KE+ Sbjct: 128 -------------VEFKENGTTSPIIIDAHAIGV-NSASWAPATIEEDGEHNGTKESRKF 173 Query: 527 TDPLS--LLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQN 584 + L++ Q ++L L GH + + SP ++ + ++ Q+ Sbjct: 174 VTGGADNLVKIWKYNSDAQTYVL---ESTLEGHSDWVRDVAWSP--TVLLRSYLASVSQD 228 Query: 585 AVIRIFSTEN----WLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNME 638 I++ +N W + + R +S G L D K LW+ N+E Sbjct: 229 RTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLE 286 >5M25-A nrPDB Length = 434 Score = 175 bits (444), Expect = 6e-44, Method: Composition-based stats. Identities = 62/299 (20%), Positives = 106/299 (35%), Gaps = 59/299 (19%) Query: 17 QTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVS 76 + V+ +V+ KT+ +WD ++ TLKGH V C F P S+ +VS Sbjct: 190 ISDVAWSSDSNLLVSASDDKTLKIWDV---SSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 246 Query: 77 ASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVAL--SALPSLISVGCADGTISIWRQNIQ 134 S D V+IW C++T+ +S + A+ + SLI DG IW Sbjct: 247 GSFDESVRIWDVKTGK---CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG 303 Query: 135 NDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRV 194 L + P + KY+LA N L K + Sbjct: 304 QCLKTLIDDDN-------PPVSFVKFSPNGKYILAATLDN--------TLKLWDYSKGKC 348 Query: 195 VAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLL 254 + GH++ K F + G + SGS+D + +W ++ +++ Sbjct: 349 LKTYTGHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK----------- 396 Query: 255 SNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAAT--ADTSLMVWEPD 311 + GH D + S H + + +A D ++ +W+ D Sbjct: 397 ----------------------LQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 433 Score = 160 bits (405), Expect = 2e-39, Method: Composition-based stats. Identities = 70/366 (19%), Positives = 125/366 (34%), Gaps = 82/366 (22%) Query: 54 TLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSAL 113 TL GH V+ V+F P+ +++ S+S D +KIW D + I + + A S+ Sbjct: 140 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV-AWSSD 198 Query: 114 PSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGT 173 +L+ D T+ IW + T+K Y C + + L+ G Sbjct: 199 SNLLVSASDDKTLKIWDVSSGKCL------KTLKGHSNYVFCCNFNPQSN---LIVSGSF 249 Query: 174 NVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW 233 + +V I ++ + + L H D V ++ F L+ S S D R+W Sbjct: 250 DESVRIW-------DVKTGKCLKTLPAHSDPVSAVHFNR----DGSLIVSSSYDGLCRIW 298 Query: 234 RIRIND----LIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQW 289 LIDD + N +Y Sbjct: 299 DTASGQCLKTLIDDDNPPVSFVKFSPNGKY------------------------------ 328 Query: 290 HESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSC-LWFT 348 +LAAT D +L +W+ + + T TG + F+ Sbjct: 329 ------ILAATLDNTLKLWDYSKGKCL---------------KTYTGHKNEKYCIFANFS 367 Query: 349 HERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSL--D 406 + ++ + +W + I + + G T V A P+ + + +L D Sbjct: 368 VTGGKWIVSGSEDNLVYIWNLQTKEIVQK---LQGHTDVVISTACHPTENIIASAALEND 424 Query: 407 QTTRLF 412 +T +L+ Sbjct: 425 KTIKLW 430 Score = 103 bits (256), Expect = 3e-22, Method: Composition-based stats. Identities = 49/302 (16%), Positives = 105/302 (34%), Gaps = 48/302 (15%) Query: 191 KCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW---RIRINDLIDDSEED 247 + L GH V S+ F P L S S D+ I++W + I + Sbjct: 134 NYALKFTLAGHTKAVSSVKFS----PNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLG 189 Query: 248 SKK--------LTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAA 299 L + ++ +I D + GH +++ ++ +++ Sbjct: 190 ISDVAWSSDSNLLVSASDDKTLKIWDV--SSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 247 Query: 300 TADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNG 359 + D S+ +W+ + S + F + +++ Sbjct: 248 SFDESVRIWDVKTGKCLKTLPA----------------HSDPVSAVHFNRDGSL-IVSSS 290 Query: 360 KTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDA 419 G R+W T + V+ + +SP+G+Y+LA +LD T +L+ Sbjct: 291 YDGLCRIWDTASGQCLKTLID--DDNPPVSFVKFSPNGKYILAATLDNTLKLW------- 341 Query: 420 SGRKREIATWHEFSRPQIHGYDMICVETVTDTR-FVSGGDEKILRSFDLPKGVAGMLQKF 478 + ++ + Y + +VT + VSG ++ ++ ++L ++QK Sbjct: 342 --DYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT--KEIVQKL 397 Query: 479 VG 480 G Sbjct: 398 QG 399 Score = 90.0 bits (221), Expect = 4e-18, Method: Composition-based stats. Identities = 58/419 (13%), Positives = 128/419 (30%), Gaps = 90/419 (21%) Query: 230 IRLWRIRINDLID-DSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQ 288 IR+ + + +D + + + ++ + + GH +SS++ Sbjct: 93 IRIQADQTPEDLDMEDNDIIEAHREQIGGSATQSKPTPVKPNYALKFTLAGHTKAVSSVK 152 Query: 289 WHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFT 348 + + L +++AD + +W + K T +G G W + Sbjct: 153 FSPNGEWLASSSADKLIKIWGAYDG---------------KFEKTISGHKLGISDVAWSS 197 Query: 349 HERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQT 408 + ++ + ++W + G + V ++P +++ S D++ Sbjct: 198 DSNL--LVSASDDKTLKIWDVSSGKCLK---TLKGHSNYVFCCNFNPQSNLIVSGSFDES 252 Query: 409 TRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVE-TVTDTRFVSGGDEKILRSFDL 467 R I+D K H + V + VS + + R +D Sbjct: 253 VR-----IWDVKTGK----CLKTLP---AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 300 Query: 468 PKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDIT 527 G L+ + +DD K +P+ Sbjct: 301 ASGQC--LKTLI-------------------------------DDDNPPVSFVKFSPN-- 325 Query: 528 DPLSLLECPPMEDQLQRHLLWPE-----VEKLYGHGFEITCLDIS---PDQKLIASACRS 579 + +++ L+ LW ++ GH E C+ + K I S Sbjct: 326 --GKYILAATLDNTLK---LWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED 380 Query: 580 NNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVC--RDRKWALWERN 636 N ++ I++ + EI L H+ + + S D+ LW+ + Sbjct: 381 N-----LVYIWNLQTK-EIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 433 Score = 85.0 bits (208), Expect = 1e-16, Method: Composition-based stats. Identities = 34/173 (19%), Positives = 77/173 (44%), Gaps = 22/173 (12%) Query: 554 LYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLK 613 L GH ++ + SP+ + +AS+ + +I+I+ + K + H L I+ + Sbjct: 141 LAGHTKAVSSVKFSPNGEWLASSS-----ADKLIKIWGAYDGKFEK-TISGHKLGISDVA 194 Query: 614 FSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTA 673 +S D L+S D+ +W+ + K K H+ ++ ++ P N+ V+ Sbjct: 195 WSSDSNLLVSASDDKTLKIWDVSSGKCL-----KTLKGHSNYVFCCNFNPQ--SNLIVSG 247 Query: 674 SRDKTVKVWRHQ-KEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLE 725 S D++V++W + + L+ H+ V+A+ + +++S + Sbjct: 248 SFDESVRIWDVKTGKC-----LKTLPAHSDPVSAVHFNRDGS---LIVSSSYD 292 Score = 81.1 bits (198), Expect = 2e-15, Method: Composition-based stats. Identities = 40/199 (20%), Positives = 80/199 (40%), Gaps = 17/199 (8%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 ++ L GH + C + +P LI S + +RI+ + +K LP HS ++ Sbjct: 222 LKTLKGHSNYVFCCNFNPQSNLIVSGSFDES-----VRIWDVKTGKCLK-TLPAHSDPVS 275 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVF 670 + F++DG ++S D +W+ L ++ P + G Sbjct: 276 AVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL-IDDDNPPVSFVK-----FSPNGKYI 329 Query: 671 VTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIY 730 + A+ D T+K+W + K L+ H I + S+ K ++S E+ +Y Sbjct: 330 LAATLDNTLKLWDYSKGKC----LKTYTGHKNEKYCIFANFSVTGGKWIVSGS-EDNLVY 384 Query: 731 LYSYTLGKFELITQLNEDI 749 +++ + Q + D+ Sbjct: 385 IWNLQTKEIVQKLQGHTDV 403 Score = 78.4 bits (191), Expect = 1e-14, Method: Composition-based stats. Identities = 30/124 (24%), Positives = 53/124 (42%), Gaps = 13/124 (10%) Query: 16 KQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCV--RFV-PDSD 72 + V K I+A T+ LWD + T GH+ E C+ F Sbjct: 316 PVSFVKFSPNGKYILAATLDNTLKLWDYSKG---KCLKTYTGHKNEKYCIFANFSVTGGK 372 Query: 73 FMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCA----DGTISI 128 ++VS SED+ V IW + +Q +Q ++ +++ + P+ + A D TI + Sbjct: 373 WIVSGSEDNLVYIWNLQT---KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKL 429 Query: 129 WRQN 132 W+ + Sbjct: 430 WKSD 433 Score = 71.1 bits (172), Expect = 2e-12, Method: Composition-based stats. Identities = 34/187 (18%), Positives = 69/187 (36%), Gaps = 20/187 (10%) Query: 552 EKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITR 611 + + GH I+ + S D L+ SA + ++I+ + +K L HS + Sbjct: 181 KTISGHKLGISDVAWSSDSNLLVSAS-----DDKTLKIWDVSSGKCLK-TLKGHSNYVFC 234 Query: 612 LKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFV 671 F+ ++S D +W+ L ++ + G++ V Sbjct: 235 CNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPV-------SAVHFNRDGSLIV 287 Query: 672 TASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYL 731 ++S D ++W A L+ I +S K +++ L+N + L Sbjct: 288 SSSYDGLCRIWDT----ASGQCLKTLID--DDNPPVSFVKFSPNGKYILAATLDN-TLKL 340 Query: 732 YSYTLGK 738 + Y+ GK Sbjct: 341 WDYSKGK 347 Score = 68.4 bits (165), Expect = 1e-11, Method: Composition-based stats. Identities = 30/130 (23%), Positives = 56/130 (43%), Gaps = 16/130 (12%) Query: 599 KPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEK-PHTRIIW 657 K L H+ ++ +KFS +G++L S D+ +W D FE K + + W Sbjct: 138 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY--DGKFEKTISGHKLGISDVAW 195 Query: 658 DADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREK 717 +D N+ V+AS DKT+K+W + L+ H+ V + + + Sbjct: 196 SSDS------NLLVSASDDKTLKIWDV----SSGKCLKTLKGHSNYVFCCNFNP---QSN 242 Query: 718 ILISVGLENG 727 +++S + Sbjct: 243 LIVSGSFDES 252 >5UZ7-B nrPDB Length = 351 Score = 173 bits (439), Expect = 2e-43, Method: Composition-based stats. Identities = 68/341 (19%), Positives = 118/341 (34%), Gaps = 50/341 (14%) Query: 41 WDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTI 100 DP+ TL+GH A++ + + DS +VSAS+D + IW D + I Sbjct: 48 IDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIW---DSYTTNKVHAI 104 Query: 101 QHYSKTIVALSALPS--LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSL 158 S ++ + PS ++ G D SI+ + ++ E G+ Sbjct: 105 PLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLS----CC 160 Query: 159 SKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGD 218 +++ + + + G T ++ IE + GH V SL+ P Sbjct: 161 RFLDDNQIVTSSGDTTCALW---------DIETGQQTTTFTGHTGDVMSLSLA----PDT 207 Query: 219 YLLCSGSQDRYIRLWRIR---INDLIDDSEEDSKKLTLLSN-KQYKFQIDDE----LRVG 270 L SG+ D +LW +R E D + N + DD + Sbjct: 208 RLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLR 267 Query: 271 INFEALIMGHDD---WISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMS 327 + E + HD+ I+S+ + +S LLA D + VW+ + Sbjct: 268 ADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKAD------------- 314 Query: 328 SKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWA 368 + SCL T + M T ++W Sbjct: 315 ---RAGVLAGHDNRVSCLGVTDDGMA-VATGSWDSFLKIWN 351 Score = 105 bits (262), Expect = 6e-23, Method: Composition-based stats. Identities = 46/212 (21%), Positives = 77/212 (36%), Gaps = 26/212 (12%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVK 84 +IV T ALWD + H +V + PD+ VS + D K Sbjct: 164 DDNQIVTSSGDTTCALWDIETGQQTTTFTG---HTGDVMSLSLAPDTRLFVSGACDASAK 220 Query: 85 IWKFTDYSHLQCIQTIQHYSKTIVALSALPSL--ISVGCADGTISIWRQNIQNDEFGLAH 142 +W D C QT + I A+ P+ + G D T ++ + +H Sbjct: 221 LW---DVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSH 277 Query: 143 EFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHE 202 + I S+S + + LLA G + N + + +D L GH+ Sbjct: 278 DNII------CGITSVSFSKSGRLLLA-GYDDFNCNVWDALKADRA-------GVLAGHD 323 Query: 203 DWVKSLAFRHQETPGDYLLCSGSQDRYIRLWR 234 + V L T + +GS D ++++W Sbjct: 324 NRVSCLGV----TDDGMAVATGSWDSFLKIWN 351 Score = 69.9 bits (169), Expect = 4e-12, Method: Composition-based stats. Identities = 43/276 (15%), Positives = 79/276 (28%), Gaps = 67/276 (24%) Query: 193 RVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLT 252 R L GH + ++ + LL S SQD + +W + + Sbjct: 57 RTRRTLRGHLAKIYAMHWG----TDSRLLVSASQDGKLIIWDSYTTNKVHAI-------- 104 Query: 253 LLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDE 312 LR W+ + + S + D ++ Sbjct: 105 -------------PLRSS------------WVMTCAYAPSGNYVACGGLDNICSIYNLKT 139 Query: 313 TSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDN 372 G + S G+ SC F + +T+ + +W + Sbjct: 140 REG------------NVRVSRELAGHTGYLSCCRFLDDNQ--IVTSSGDTTCALWDIETG 185 Query: 373 IICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEF 432 G T DV ++ +P ++ + D + +L+ RE F Sbjct: 186 QQTTTFTG---HTGDVMSLSLAPDTRLFVSGACDASAKLW---------DVREGMCRQTF 233 Query: 433 SRPQIHGYDMICVETV-TDTRFVSGGDEKILRSFDL 467 + H D+ + F +G D+ R FDL Sbjct: 234 T---GHESDINAICFFPNGNAFATGSDDATCRLFDL 266 Score = 56.8 bits (135), Expect = 4e-08, Method: Composition-based stats. Identities = 31/175 (17%), Positives = 62/175 (35%), Gaps = 20/175 (11%) Query: 552 EKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITR 611 +L GH ++C D +++ S+ + ++ E + H+ + Sbjct: 148 RELAGHTGYLSCCRFLDDNQIVTSSG------DTTCALWDIETGQQTTTFT-GHTGDVMS 200 Query: 612 LKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFV 671 L + D + +S D LW+ H I + P GN F Sbjct: 201 LSLAPDTRLFVSGACDASAKLWDVREGMCRQTFT-----GHESDINAICFFP--NGNAFA 253 Query: 672 TASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLEN 726 T S D T +++ + AD ++ + H + I+ S + L+ G ++ Sbjct: 254 TGSDDATCRLFDLR---ADQELM--TYSHDNIICGIT-SVSFSKSGRLLLAGYDD 302 Score = 51.1 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 30/161 (18%), Positives = 58/161 (36%), Gaps = 16/161 (9%) Query: 552 EKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITR 611 L GH +I + D +L+ SA + + I+ + A+P S + Sbjct: 60 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLI-----IWDSYT-TNKVHAIPLRSSWVMT 113 Query: 612 LKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNE-KPHTRIIWDADWAPLEFGNVF 670 ++ G ++ D +++ + +R E HT + + L+ N Sbjct: 114 CAYAPSGNYVACGGLDNICSIYNLKTREGN--VRVSRELAGHTGYL--SCCRFLD-DNQI 168 Query: 671 VTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHD 711 VT+S D T +W + HT V ++S+ Sbjct: 169 VTSSGDTTCALWDIETGQQTTTFTG----HTGDVMSLSLAP 205 Score = 49.5 bits (116), Expect = 5e-06, Method: Composition-based stats. Identities = 56/333 (16%), Positives = 103/333 (30%), Gaps = 55/333 (16%) Query: 372 NIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHE 431 I R + G + + W L++ S D ++ + + ++W Sbjct: 53 RIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSW-- 110 Query: 432 FSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPK---------GVAGMLQKFVGIQ 482 M C + GG + I ++L +AG + Sbjct: 111 ---------VMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCR 161 Query: 483 FEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITD----PLSLLECPPM 538 F + +++ S+ L + E ++ T D+ P + L Sbjct: 162 FLDDNQIVTSSGDTTCALWDI-------ETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGA 214 Query: 539 EDQLQRHLLWPEVEKL-----YGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTE 593 D + LW E + GH +I + P+ A+ +A R+F Sbjct: 215 CDASAK--LWDVREGMCRQTFTGHESDINAICFFPNGNAFATGS-----DDATCRLFDLR 267 Query: 594 NWLEIKPALPFHSLTI---TRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEK 650 + + H I T + FSK G+ LL+ D +W+ D R Sbjct: 268 --ADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKAD-----RAGVLA 320 Query: 651 PHTRIIWDADWAPLEFGNVFVTASRDKTVKVWR 683 H + + + G T S D +K+W Sbjct: 321 GHDNRV--SCLGVTDDGMAVATGSWDSFLKIWN 351 Score = 41.0 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 24/169 (14%), Positives = 47/169 (27%), Gaps = 16/169 (9%) Query: 601 ALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDAD 660 L H I + + D + L+S +D K +W+ + + + Sbjct: 61 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYT-----TNKVHAIPLRSSWVMTCA 115 Query: 661 WAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHD-------SM 713 +AP GN D ++ + + V HT ++ D S Sbjct: 116 YAP--SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG 173 Query: 714 IREKILISVGLENGEIYLYSYTLGKFELITQLNED--ITPADKITRLRW 760 L + +T L + ++ A + W Sbjct: 174 DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLW 222 >4YCZ-A nrPDB Length = 876 Score = 173 bits (438), Expect = 3e-43, Method: Composition-based stats. Identities = 62/316 (19%), Positives = 118/316 (37%), Gaps = 53/316 (16%) Query: 26 VKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPD--SDFMVSASEDHHV 83 +++ + +TI +++ IE + + TLKGH+ V CV + + + SA D V Sbjct: 30 GRRLATCSSDRTIKIFE-IEGETQRLTETLKGHDGAVWCVSWAHPKYGNILASAGYDGKV 88 Query: 84 KIWKFTDYSHLQCIQTIQHYSKTIVALSALPS----LISVGCADGTISI--WRQNIQNDE 137 IW+ + + Q I + ++ +S P L++ +DG +S+ +R N Sbjct: 89 LIWRELNGAW-QRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNVSVLEFRDNSWEHS 147 Query: 138 FGLAHEFTIKKGFFYPLCLSLS-------KVEEKKYLLAIGGTNVNVFIASFILSDSGIE 190 AH + + P S GG++ + I ++ D Sbjct: 148 IFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNALKIWAY---DPATN 204 Query: 191 KCRVVAE-LEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSK 249 ++ E L GH DWV+ +A+ Y + S S+DR +R+W Sbjct: 205 TYKLEREPLTGHTDWVRDVAWSPTVLQKSY-IASASEDRTVRIW---------------- 247 Query: 250 KLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWE 309 + + + ++ D + + W S L A+ D + +W+ Sbjct: 248 --------------TSDPANPLQWNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVTLWK 293 Query: 310 PDETSGIWVCSLRLGE 325 + G W C + E Sbjct: 294 EN-LKGEWECVKTIEE 308 Score = 82.3 bits (201), Expect = 9e-16, Method: Composition-based stats. Identities = 45/300 (15%), Positives = 92/300 (30%), Gaps = 56/300 (18%) Query: 166 YLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGS 225 LA ++ + I E R+ L+GH+ V +++ H + +L S Sbjct: 31 RRLATCSSDRTIKIFEIEG-----ETQRLTETLKGHDGAVWCVSWAHPKY--GNILASAG 83 Query: 226 QDRYIRLWR-------------IRINDLIDDSEEDSKKLTLLS---NKQYKFQIDDELRV 269 D + +WR + + S + LL+ + + E R Sbjct: 84 YDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNVSVL--EFRD 141 Query: 270 GINFEALIMGHDDWISSLQWHES-----------------RLQLLAATADTSLMVWEPDE 312 ++ H ++S+ W + + + +D +L +W D Sbjct: 142 NSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNALKIWAYDP 201 Query: 313 TSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWF-THERMDFFLTNGKTGSWRMWATKD 371 + + TG + W T + + + + + R+W + Sbjct: 202 ATNTYKLE----------REPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDP 251 Query: 372 NIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHE 431 + V ++WS SG L A+ D L+ + G + T E Sbjct: 252 ANPLQWNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVTLWKE---NLKGEWECVKTIEE 308 Score = 81.5 bits (199), Expect = 1e-15, Method: Composition-based stats. Identities = 28/156 (17%), Positives = 58/156 (37%), Gaps = 8/156 (5%) Query: 23 IHKVKKIVAFGAGKTIALWDPI-EPNNKGVYAT-LKGHEAEVTCVRFVP---DSDFMVSA 77 ++ V G+ + +W N + L GH V V + P ++ SA Sbjct: 179 STGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASA 238 Query: 78 SEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSA--LPSLISVGCADGTISIWRQNIQN 135 SED V+IW + LQ + ++ + +S ++++ D +++W++N Sbjct: 239 SEDRTVRIWTSDPANPLQWNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVTLWKEN-LK 297 Query: 136 DEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIG 171 E+ G + + ++ A G Sbjct: 298 GEWECVKTIEEGGGGSGGGGQAKGPTQPEQASPAKG 333 Score = 67.2 bits (162), Expect = 3e-11, Method: Composition-based stats. Identities = 37/197 (18%), Positives = 70/197 (35%), Gaps = 25/197 (12%) Query: 279 GHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSS 338 GHDD I +L ++D ++ ++E + + + T G Sbjct: 16 GHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGE-------------TQRLTETLKGHD 62 Query: 339 GGFWSCLWFTHERM-DFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPS- 396 G W C+ + H + + + G G +W + N + + V ++WSP Sbjct: 63 GAVW-CVSWAHPKYGNILASAGYDGKVLIWR-ELNGAWQRIFDFALHKASVNVVSWSPHE 120 Query: 397 -GEYLLATSLDQTTRL-------FAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETV 448 G L S D + + I+ A G +W + P ++ Sbjct: 121 AGCLLACASSDGNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKST 180 Query: 449 TDTRFVSGGDEKILRSF 465 + RFV+GG + L+ + Sbjct: 181 GNRRFVTGGSDNALKIW 197 Score = 55.7 bits (132), Expect = 8e-08, Method: Composition-based stats. Identities = 41/221 (18%), Positives = 80/221 (36%), Gaps = 31/221 (14%) Query: 548 WPEVEKLYGHGFEITCLDISP--DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFH 605 W + H + + SP L+A A NV + F +W H Sbjct: 98 WQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNV---SVLEFRDNSW--EHSIFHAH 152 Query: 606 SLTITRLKF-----------------SKDGKFLLSVCRDRKWALWERNMEDNTFELRFKN 648 L + + + S + ++ D +W + NT++L + Sbjct: 153 GLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREP 212 Query: 649 EKPHTRIIWDADWAP-LEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAI 707 HT + D W+P + + +AS D+TV++W + + + AV + Sbjct: 213 LTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPANPLQWNCK-VLNFDAAVWRV 271 Query: 708 SIHDSMIREKILISVGLENGEIYLYSYTL-GKFELITQLNE 747 S S+ + S G + ++ L+ L G++E + + E Sbjct: 272 SW--SLSGNVLAASGG--DNKVTLWKENLKGEWECVKTIEE 308 Score = 48.7 bits (114), Expect = 9e-06, Method: Composition-based stats. Identities = 28/153 (18%), Positives = 53/153 (34%), Gaps = 20/153 (13%) Query: 604 FHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAP 663 H I G+ L + DR ++E E K H +W WA Sbjct: 16 GHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTET---LKGHDGAVWCVSWAH 72 Query: 664 LEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVG 723 ++GN+ +A D V +WR + A + + ++ H +V +S L++ Sbjct: 73 PKYGNILASAGYDGKVLIWR-ELNGAWQRIFDFAL-HKASVNVVSWSPHEAG--CLLACA 128 Query: 724 LENGEI-------------YLYSYTLGKFELIT 743 +G + +++ LG + Sbjct: 129 SSDGNVSVLEFRDNSWEHSIFHAHGLGVNSVSW 161 >2H9P-A nrPDB Length = 329 Score = 171 bits (432), Expect = 1e-42, Method: Composition-based stats. Identities = 62/299 (20%), Positives = 106/299 (35%), Gaps = 59/299 (19%) Query: 17 QTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVS 76 + V+ +V+ KT+ +WD ++ TLKGH V C F P S+ +VS Sbjct: 85 ISDVAWSSDSNLLVSASDDKTLKIWDV---SSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 141 Query: 77 ASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVAL--SALPSLISVGCADGTISIWRQNIQ 134 S D V+IW C++T+ +S + A+ + SLI DG IW Sbjct: 142 GSFDESVRIWDVKTGK---CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG 198 Query: 135 NDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRV 194 L + P + KY+LA N L K + Sbjct: 199 QCLKTLIDDDN-------PPVSFVKFSPNGKYILAATLDN--------TLKLWDYSKGKC 243 Query: 195 VAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLL 254 + GH++ K F + G + SGS+D + +W ++ +++ Sbjct: 244 LKTYTGHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK----------- 291 Query: 255 SNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAAT--ADTSLMVWEPD 311 + GH D + S H + + +A D ++ +W+ D Sbjct: 292 ----------------------LQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 328 Score = 156 bits (393), Expect = 4e-38, Method: Composition-based stats. Identities = 70/366 (19%), Positives = 125/366 (34%), Gaps = 82/366 (22%) Query: 54 TLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSAL 113 TL GH V+ V+F P+ +++ S+S D +KIW D + I + + A S+ Sbjct: 35 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV-AWSSD 93 Query: 114 PSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGT 173 +L+ D T+ IW + T+K Y C + + L+ G Sbjct: 94 SNLLVSASDDKTLKIWDVSSGKCL------KTLKGHSNYVFCCNFNPQSN---LIVSGSF 144 Query: 174 NVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW 233 + +V I ++ + + L H D V ++ F L+ S S D R+W Sbjct: 145 DESVRIW-------DVKTGKCLKTLPAHSDPVSAVHFNR----DGSLIVSSSYDGLCRIW 193 Query: 234 RIRIND----LIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQW 289 LIDD + N +Y Sbjct: 194 DTASGQCLKTLIDDDNPPVSFVKFSPNGKY------------------------------ 223 Query: 290 HESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSC-LWFT 348 +LAAT D +L +W+ + + T TG + F+ Sbjct: 224 ------ILAATLDNTLKLWDYSKGKCL---------------KTYTGHKNEKYCIFANFS 262 Query: 349 HERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSL--D 406 + ++ + +W + I + + G T V A P+ + + +L D Sbjct: 263 VTGGKWIVSGSEDNLVYIWNLQTKEIVQK---LQGHTDVVISTACHPTENIIASAALEND 319 Query: 407 QTTRLF 412 +T +L+ Sbjct: 320 KTIKLW 325 Score = 101 bits (250), Expect = 2e-21, Method: Composition-based stats. Identities = 51/321 (15%), Positives = 108/321 (33%), Gaps = 44/321 (13%) Query: 170 IGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRY 229 G F + + L GH V S+ F P L S S D+ Sbjct: 8 SSGRENLYFQGTQSKPTPVKPNYALKFTLAGHTKAVSSVKFS----PNGEWLASSSADKL 63 Query: 230 IRLW---RIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGI------NFEALIMGH 280 I++W + I + + S+ D+ + I + GH Sbjct: 64 IKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGH 123 Query: 281 DDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGG 340 +++ ++ +++ + D S+ +W+ + Sbjct: 124 SNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPA----------------HSD 167 Query: 341 FWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYL 400 S + F + +++ G R+W T + V+ + +SP+G+Y+ Sbjct: 168 PVSAVHFNRDGSL-IVSSSYDGLCRIWDTASGQCLKTLID--DDNPPVSFVKFSPNGKYI 224 Query: 401 LATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTR-FVSGGDE 459 LA +LD T +L+ + ++ + Y + +VT + VSG ++ Sbjct: 225 LAATLDNTLKLW---------DYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED 275 Query: 460 KILRSFDLPKGVAGMLQKFVG 480 ++ ++L ++QK G Sbjct: 276 NLVYIWNLQT--KEIVQKLQG 294 Score = 82.6 bits (202), Expect = 6e-16, Method: Composition-based stats. Identities = 34/172 (19%), Positives = 76/172 (44%), Gaps = 20/172 (11%) Query: 554 LYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLK 613 L GH ++ + SP+ + +AS+ + +I+I+ + K + H L I+ + Sbjct: 36 LAGHTKAVSSVKFSPNGEWLASSS-----ADKLIKIWGAYDGKFEK-TISGHKLGISDVA 89 Query: 614 FSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTA 673 +S D L+S D+ +W+ + K K H+ ++ ++ P N+ V+ Sbjct: 90 WSSDSNLLVSASDDKTLKIWDVSSGKCL-----KTLKGHSNYVFCCNFNPQ--SNLIVSG 142 Query: 674 SRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLE 725 S D++V++W + L+ H+ V+A+ + +++S + Sbjct: 143 SFDESVRIWDVKTGKC----LKTLPAHSDPVSAVHFNRDGS---LIVSSSYD 187 Score = 79.2 bits (193), Expect = 7e-15, Method: Composition-based stats. Identities = 40/199 (20%), Positives = 80/199 (40%), Gaps = 17/199 (8%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 ++ L GH + C + +P LI S + +RI+ + +K LP HS ++ Sbjct: 117 LKTLKGHSNYVFCCNFNPQSNLIVSGSFDES-----VRIWDVKTGKCLK-TLPAHSDPVS 170 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVF 670 + F++DG ++S D +W+ L ++ P + G Sbjct: 171 AVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL-IDDDNPPVSFVK-----FSPNGKYI 224 Query: 671 VTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIY 730 + A+ D T+K+W + K L+ H I + S+ K ++S E+ +Y Sbjct: 225 LAATLDNTLKLWDYSKGKC----LKTYTGHKNEKYCIFANFSVTGGKWIVSGS-EDNLVY 279 Query: 731 LYSYTLGKFELITQLNEDI 749 +++ + Q + D+ Sbjct: 280 IWNLQTKEIVQKLQGHTDV 298 Score = 76.5 bits (186), Expect = 5e-14, Method: Composition-based stats. Identities = 30/124 (24%), Positives = 53/124 (42%), Gaps = 13/124 (10%) Query: 16 KQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCV--RFV-PDSD 72 + V K I+A T+ LWD + T GH+ E C+ F Sbjct: 211 PVSFVKFSPNGKYILAATLDNTLKLWDYSKG---KCLKTYTGHKNEKYCIFANFSVTGGK 267 Query: 73 FMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCA----DGTISI 128 ++VS SED+ V IW + +Q +Q ++ +++ + P+ + A D TI + Sbjct: 268 WIVSGSEDNLVYIWNLQT---KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKL 324 Query: 129 WRQN 132 W+ + Sbjct: 325 WKSD 328 Score = 69.2 bits (167), Expect = 7e-12, Method: Composition-based stats. Identities = 34/187 (18%), Positives = 69/187 (36%), Gaps = 20/187 (10%) Query: 552 EKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITR 611 + + GH I+ + S D L+ SA + ++I+ + +K L HS + Sbjct: 76 KTISGHKLGISDVAWSSDSNLLVSAS-----DDKTLKIWDVSSGKCLK-TLKGHSNYVFC 129 Query: 612 LKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFV 671 F+ ++S D +W+ L ++ + G++ V Sbjct: 130 CNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPV-------SAVHFNRDGSLIV 182 Query: 672 TASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYL 731 ++S D ++W A L+ I +S K +++ L+N + L Sbjct: 183 SSSYDGLCRIWDT----ASGQCLKTLID--DDNPPVSFVKFSPNGKYILAATLDN-TLKL 235 Query: 732 YSYTLGK 738 + Y+ GK Sbjct: 236 WDYSKGK 242 Score = 66.5 bits (160), Expect = 4e-11, Method: Composition-based stats. Identities = 30/130 (23%), Positives = 56/130 (43%), Gaps = 16/130 (12%) Query: 599 KPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEK-PHTRIIW 657 K L H+ ++ +KFS +G++L S D+ +W D FE K + + W Sbjct: 33 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY--DGKFEKTISGHKLGISDVAW 90 Query: 658 DADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREK 717 +D N+ V+AS DKT+K+W + L+ H+ V + + + Sbjct: 91 SSDS------NLLVSASDDKTLKIWDV----SSGKCLKTLKGHSNYVFCCNFNP---QSN 137 Query: 718 ILISVGLENG 727 +++S + Sbjct: 138 LIVSGSFDES 147 >6MZM-G nrPDB Length = 800 Score = 169 bits (427), Expect = 5e-42, Method: Composition-based stats. Identities = 55/228 (24%), Positives = 80/228 (35%), Gaps = 29/228 (12%) Query: 10 IFIGAN-KQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFV 68 I G + S +++ T+ LW KGH V +F Sbjct: 538 ILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL---QTFTCLVGYKGHNYPVWDTQFS 594 Query: 69 PDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP--SLISVGCADGTI 126 P + VS D ++W H Q ++ + + P + ++ G AD T+ Sbjct: 595 PYGYYFVSGGHDRVARLWATD---HYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTV 651 Query: 127 SIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSD 186 +W N FT KG + L S LA G T+ V + Sbjct: 652 RLWDVLNGN----CVRIFTGHKGPIHSLTFS-----PNGRFLATGATDGRVLLW------ 696 Query: 187 SGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWR 234 I +V EL+GH D V SL F +L SGS D +RLW Sbjct: 697 -DIGHGLMVGELKGHTDTVCSLRFSR----DGEILASGSMDNTVRLWD 739 Score = 116 bits (289), Expect = 4e-26, Method: Composition-based stats. Identities = 37/196 (18%), Positives = 73/196 (37%), Gaps = 19/196 (9%) Query: 11 FIGAN-KQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVP 69 + G N V+ G + LW ++A GH A+V C RF P Sbjct: 581 YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFA---GHLADVNCTRFHP 637 Query: 70 DSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS--LISVGCADGTIS 127 +S+++ + S D V++W + C++ + I +L+ P+ ++ G DG + Sbjct: 638 NSNYVATGSADRTVRLWDVLNG---NCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVL 694 Query: 128 IWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDS 187 +W + H + + + + + +LA G + V + I + Sbjct: 695 LWD---------IGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFE 745 Query: 188 GIEKCRVVAELEGHED 203 +E GH + Sbjct: 746 DLETDDF-TTATGHIN 760 Score = 111 bits (278), Expect = 8e-25, Method: Composition-based stats. Identities = 37/224 (16%), Positives = 71/224 (31%), Gaps = 31/224 (13%) Query: 98 QTIQHYSKTIVALSALPS--LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLC 155 + + +S + S P + DGT+ +W F + + Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQT----FTCLVGYKGHNYPVWDTQ 592 Query: 156 LSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQET 215 S Y GG + + + + + GH V F Sbjct: 593 FS-----PYGYYFVSGGHDRVARLW-------ATDHYQPLRIFAGHLADVNCTRFH---- 636 Query: 216 PGDYLLCSGSQDRYIRLWRI---RINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGI- 271 P + +GS DR +RLW + + + LT N ++ + RV + Sbjct: 637 PNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLW 696 Query: 272 -----NFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEP 310 + GH D + SL++ L + + D ++ +W+ Sbjct: 697 DIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDA 740 Score = 105 bits (261), Expect = 8e-23, Method: Composition-based stats. Identities = 40/224 (17%), Positives = 76/224 (33%), Gaps = 33/224 (14%) Query: 198 LEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLI---DDSEEDSKKLTLL 254 L GH V +F P L S S+D +RLW ++ + Sbjct: 539 LYGHSGPVYGASFS----PDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFS 594 Query: 255 SNKQYKFQIDDELRVGI------NFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVW 308 Y + + + GH ++ ++H + + +AD ++ +W Sbjct: 595 PYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLW 654 Query: 309 EPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWA 368 + + + + + G G S + + R F T G +W Sbjct: 655 DVLNGNCVRIFT---------------GHKGPIHSLTFSPNGR--FLATGATDGRVLLWD 697 Query: 369 TKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLF 412 ++ + + G T V + +S GE L + S+D T RL+ Sbjct: 698 IGHGLMVGE---LKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738 Score = 78.0 bits (190), Expect = 1e-14, Method: Composition-based stats. Identities = 36/281 (12%), Positives = 72/281 (25%), Gaps = 45/281 (16%) Query: 213 QETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGIN 272 T L+ G D +R+ Sbjct: 477 DVTDDSSLIAGGFADSTVRV--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 534 Query: 273 FEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGI--------WVCSLRLG 324 ++ GH + + R LL+++ D ++ +W + + V + Sbjct: 535 XXKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFS 594 Query: 325 EMSSKGASTATGSSGGFWS------------------CLWFTHERMDFFLTNGKTGSWRM 366 S W+ C F H ++ T + R+ Sbjct: 595 PYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRF-HPNSNYVATGSADRTVRL 653 Query: 367 WATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREI 426 W N C + G + + +SP+G +L + D L+ G + Sbjct: 654 WDV-LNGNCVRIFT--GHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKG- 709 Query: 427 ATWHEFSRPQIHGYDMICVE-TVTDTRFVSGGDEKILRSFD 466 H + + + SG + +R +D Sbjct: 710 -----------HTDTVCSLRFSRDGEILASGSMDNTVRLWD 739 Score = 77.2 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 43/233 (18%), Positives = 84/233 (36%), Gaps = 32/233 (13%) Query: 552 EKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITR 611 + LYGH + SPD+ + S+ +R++S + + + H+ + Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGT-----VRLWSLQTFTCL-VGYKGHNYPVWD 590 Query: 612 LKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFV 671 +FS G + +S DR LW + + N Sbjct: 591 TQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVN-------CTRFHPNSNYVA 643 Query: 672 TASRDKTVKVWRHQKEPADDYVLEASI-KHTKAVTAISIHDSMIREKILISVGLENGEIY 730 T S D+TV++W + H + +++ + ++ G +G + Sbjct: 644 TGSADRTVRLWDV-----LNGNCVRIFTGHKGPIHSLTFSPNGR----FLATGATDGRVL 694 Query: 731 LYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIY 783 L+ G + E D + LR+S R+G++ L GS D + R++ Sbjct: 695 LWDIGHG-----LMVGELKGHTDTVCSLRFS---RDGEI-LASGSMDNTVRLW 738 Score = 75.7 bits (184), Expect = 7e-14, Method: Composition-based stats. Identities = 28/140 (20%), Positives = 51/140 (36%), Gaps = 13/140 (9%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 + GH ++ C P+ +A+ + +R++ N ++ H I Sbjct: 620 LRIFAGHLADVNCTRFHPNSNYVATGS-----ADRTVRLWDVLNGNCVRIFT-GHKGPIH 673 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVF 670 L FS +G+FL + D + LW+ EL+ + G + Sbjct: 674 SLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTV-------CSLRFSRDGEIL 726 Query: 671 VTASRDKTVKVWRHQKEPAD 690 + S D TV++W K D Sbjct: 727 ASGSMDNTVRLWDAIKAFED 746 Score = 61.8 bits (148), Expect = 1e-09, Method: Composition-based stats. Identities = 25/110 (22%), Positives = 40/110 (36%), Gaps = 7/110 (6%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 V GH I L SP+ + +A+ V I L H+ T+ Sbjct: 662 VRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGE------LKGHTDTVC 715 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNME-DNTFELRFKNEKPHTRIIWDA 659 L+FS+DG+ L S D LW+ ++ F H + ++ Sbjct: 716 SLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPENS 765 >6F3T-A nrPDB Length = 608 Score = 169 bits (427), Expect = 5e-42, Method: Composition-based stats. Identities = 55/228 (24%), Positives = 80/228 (35%), Gaps = 29/228 (12%) Query: 10 IFIGAN-KQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFV 68 I G + S +++ T+ LW KGH V +F Sbjct: 346 ILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL---QTFTCLVGYKGHNYPVWDTQFS 402 Query: 69 PDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP--SLISVGCADGTI 126 P + VS D ++W H Q ++ + + P + ++ G AD T+ Sbjct: 403 PYGYYFVSGGHDRVARLWATD---HYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTV 459 Query: 127 SIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSD 186 +W N FT KG + L S LA G T+ V + Sbjct: 460 RLWDVLNGN----CVRIFTGHKGPIHSLTFS-----PNGRFLATGATDGRVLLW------ 504 Query: 187 SGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWR 234 I +V EL+GH D V SL F +L SGS D +RLW Sbjct: 505 -DIGHGLMVGELKGHTDTVCSLRFSR----DGEILASGSMDNTVRLWD 547 Score = 130 bits (325), Expect = 3e-30, Method: Composition-based stats. Identities = 50/315 (15%), Positives = 98/315 (31%), Gaps = 49/315 (15%) Query: 8 EAIFIGANKQTQVSDIHKVKKIVAFGA-GKTIALWDPIEPNNKGVYATLKGHEAEVTCVR 66 F+ A + D+ ++A G T+ +W ++ V+ Sbjct: 271 FYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVT--------------PKKLRSVK 316 Query: 67 FVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS--LISVGCADG 124 D + S+D +I D ++ + +S + S P + DG Sbjct: 317 QASDLSLIDKESDDVLERI---MDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDG 373 Query: 125 TISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFIL 184 T+ +W F + + S Y GG + + Sbjct: 374 TVRLWSLQT----FTCLVGYKGHNYPVWDTQFS-----PYGYYFVSGGHDRVARLW---- 420 Query: 185 SDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI---RINDLI 241 + + + GH V F P + +GS DR +RLW + + Sbjct: 421 ---ATDHYQPLRIFAGHLADVNCTRFH----PNSNYVATGSADRTVRLWDVLNGNCVRIF 473 Query: 242 DDSEEDSKKLTLLSNKQYKFQIDDELRVGI------NFEALIMGHDDWISSLQWHESRLQ 295 + LT N ++ + RV + + GH D + SL++ Sbjct: 474 TGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEI 533 Query: 296 LLAATADTSLMVWEP 310 L + + D ++ +W+ Sbjct: 534 LASGSMDNTVRLWDA 548 Score = 116 bits (289), Expect = 4e-26, Method: Composition-based stats. Identities = 37/196 (18%), Positives = 73/196 (37%), Gaps = 19/196 (9%) Query: 11 FIGAN-KQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVP 69 + G N V+ G + LW ++A GH A+V C RF P Sbjct: 389 YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFA---GHLADVNCTRFHP 445 Query: 70 DSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS--LISVGCADGTIS 127 +S+++ + S D V++W + C++ + I +L+ P+ ++ G DG + Sbjct: 446 NSNYVATGSADRTVRLWDVLNG---NCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVL 502 Query: 128 IWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDS 187 +W + H + + + + + +LA G + V + I + Sbjct: 503 LWD---------IGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFE 553 Query: 188 GIEKCRVVAELEGHED 203 +E GH + Sbjct: 554 DLETDDF-TTATGHIN 568 Score = 114 bits (286), Expect = 1e-25, Method: Composition-based stats. Identities = 50/309 (16%), Positives = 99/309 (32%), Gaps = 60/309 (19%) Query: 113 LPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGG 172 SLI+ G AD T+ +W S++ + + A Sbjct: 289 DSSLIAGGFADSTVRVW---------------------------SVTPKKLRSVKQASDL 321 Query: 173 TNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRL 232 + ++ + + + L GH V +F P L S S+D +RL Sbjct: 322 SLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFS----PDRNYLLSSSEDGTVRL 377 Query: 233 WRIRINDLI---DDSEEDSKKLTLLSNKQYKFQIDDELRVGI------NFEALIMGHDDW 283 W ++ + Y + + + GH Sbjct: 378 WSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLAD 437 Query: 284 ISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWS 343 ++ ++H + + +AD ++ +W+ + + + + G G S Sbjct: 438 VNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFT---------------GHKGPIHS 482 Query: 344 CLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLAT 403 + + R F T G +W ++ + + G T V + +S GE L + Sbjct: 483 LTFSPNGR--FLATGATDGRVLLWDIGHGLMVGE---LKGHTDTVCSLRFSRDGEILASG 537 Query: 404 SLDQTTRLF 412 S+D T RL+ Sbjct: 538 SMDNTVRLW 546 Score = 88.8 bits (218), Expect = 9e-18, Method: Composition-based stats. Identities = 42/281 (14%), Positives = 82/281 (29%), Gaps = 45/281 (16%) Query: 213 QETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGIN 272 T L+ G D +R+W + L + L + +I DE Sbjct: 285 DVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTAS-- 342 Query: 273 FEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGI--------WVCSLRLG 324 ++ GH + + R LL+++ D ++ +W + + V + Sbjct: 343 ELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFS 402 Query: 325 EMSSKGASTATGSSGGFWS------------------CLWFTHERMDFFLTNGKTGSWRM 366 S W+ C F H ++ T + R+ Sbjct: 403 PYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRF-HPNSNYVATGSADRTVRL 461 Query: 367 WATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREI 426 W N C + G + + +SP+G +L + D L+ G + Sbjct: 462 WDV-LNGNCVRIFT--GHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKG- 517 Query: 427 ATWHEFSRPQIHGYDMICVE-TVTDTRFVSGGDEKILRSFD 466 H + + + SG + +R +D Sbjct: 518 -----------HTDTVCSLRFSRDGEILASGSMDNTVRLWD 547 Score = 78.8 bits (192), Expect = 8e-15, Method: Composition-based stats. Identities = 44/235 (18%), Positives = 86/235 (36%), Gaps = 32/235 (13%) Query: 550 EVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTI 609 E++ LYGH + SPD+ + S+ +R++S + + + H+ + Sbjct: 343 ELKILYGHSGPVYGASFSPDRNYLLSSSEDGT-----VRLWSLQTFTCL-VGYKGHNYPV 396 Query: 610 TRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNV 669 +FS G + +S DR LW + + N Sbjct: 397 WDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVN-------CTRFHPNSNY 449 Query: 670 FVTASRDKTVKVWRHQKEPADDYVLEASI-KHTKAVTAISIHDSMIREKILISVGLENGE 728 T S D+TV++W + H + +++ + ++ G +G Sbjct: 450 VATGSADRTVRLWDV-----LNGNCVRIFTGHKGPIHSLTFSPNGR----FLATGATDGR 500 Query: 729 IYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIY 783 + L+ G + E D + LR+S R+G++ L GS D + R++ Sbjct: 501 VLLWDIGHG-----LMVGELKGHTDTVCSLRFS---RDGEI-LASGSMDNTVRLW 546 Score = 75.7 bits (184), Expect = 7e-14, Method: Composition-based stats. Identities = 28/140 (20%), Positives = 51/140 (36%), Gaps = 13/140 (9%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 + GH ++ C P+ +A+ + +R++ N ++ H I Sbjct: 428 LRIFAGHLADVNCTRFHPNSNYVATGS-----ADRTVRLWDVLNGNCVRIFT-GHKGPIH 481 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVF 670 L FS +G+FL + D + LW+ EL+ + G + Sbjct: 482 SLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTV-------CSLRFSRDGEIL 534 Query: 671 VTASRDKTVKVWRHQKEPAD 690 + S D TV++W K D Sbjct: 535 ASGSMDNTVRLWDAIKAFED 554 Score = 66.8 bits (161), Expect = 3e-11, Method: Composition-based stats. Identities = 55/295 (18%), Positives = 92/295 (31%), Gaps = 66/295 (22%) Query: 524 PDITDPLSLLECPPMEDQLQRHLLWPEV-------EKLYGHGFEITCLDISPDQKLIASA 576 P++ D L + M++ +R L P+ L + +T +D++ D LIA Sbjct: 238 PELKDSDKLDKIMNMKETTKRVRLGPDCLPSICFYTFLNAYQG-LTAVDVTDDSSLIAGG 296 Query: 577 CRSNNVQNAVI---RIFSTENWLEIKPALP----------------------FHSLTITR 611 + V+ + ++ S + ++ HS + Sbjct: 297 FADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYG 356 Query: 612 LKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFV 671 FS D +LLS D LW F K H +WD ++P +G FV Sbjct: 357 ASFSPDRNYLLSSSEDGTVRLWSLQT----FTC-LVGYKGHNYPVWDTQFSP--YGYYFV 409 Query: 672 TASRDKTVKVWRHQKEPADDYVLEASI-KHTKAVTAISIHDSMIREKILISVGLENGEIY 730 + D+ ++W D Y H V H + ++ G + + Sbjct: 410 SGGHDRVARLW-----ATDHYQPLRIFAGHLADVNCTRFHPN----SNYVATGSADRTVR 460 Query: 731 LYSYTLGKFEL--------ITQLNED------ITPADKITRLRW--SHLKRNGKL 769 L+ G I L T A L W H G+L Sbjct: 461 LWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL 515 Score = 61.8 bits (148), Expect = 1e-09, Method: Composition-based stats. Identities = 25/110 (22%), Positives = 40/110 (36%), Gaps = 7/110 (6%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 V GH I L SP+ + +A+ V I L H+ T+ Sbjct: 470 VRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGE------LKGHTDTVC 523 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNME-DNTFELRFKNEKPHTRIIWDA 659 L+FS+DG+ L S D LW+ ++ F H + ++ Sbjct: 524 SLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPENS 573 >5OPT-p nrPDB Length = 318 Score = 168 bits (425), Expect = 9e-42, Method: Composition-based stats. Identities = 57/307 (18%), Positives = 107/307 (34%), Gaps = 42/307 (13%) Query: 28 KIVAFGAGKTIALWDPIEPNNKG------VYATLKGHEAEVTCVRFVPDSDFMVSASEDH 81 K V+ T+ W N L+GH A V+ V + DF VSAS DH Sbjct: 30 KAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAFVSDVALSNNGDFAVSASWDH 89 Query: 82 HVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS--LISVGCADGTISIWRQNIQNDEFG 139 +++W C ++K +++++ P I G D + +W + Sbjct: 90 SLRLWNLQTGV---CQHKFLGHTKDVLSVTFSPDNRQIVSGGRDNALRVWNVKGE----- 141 Query: 140 LAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELE 199 H + C+ S E +++ G N ++ I R++ +L+ Sbjct: 142 CLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDN--------LVKVWDIASGRLLTDLK 193 Query: 200 GHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDD--SEEDSKKLTLLSNK 257 GH +++ S+ P L S +D RLW + + + + + ++ N+ Sbjct: 194 GHTNYITSVTVS----PDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPINQICFSPNR 249 Query: 258 QYKFQI-----------DDELRVGINFEALIMGHDD-WISSLQWHESRLQLLAATADTSL 305 + + ++ V + EA S+ W L + D + Sbjct: 250 YWMCAATEKGIRIFDLENKDVIVELAPEAQQKSKKTPECMSIAWSADGNTLYSGYTDNVI 309 Query: 306 MVWEPDE 312 VW E Sbjct: 310 RVWSVSE 316 Score = 164 bits (415), Expect = 1e-40, Method: Composition-based stats. Identities = 41/213 (19%), Positives = 81/213 (38%), Gaps = 38/213 (17%) Query: 269 VGINFEALIMGHDDWISSLQWH---ESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGE 325 + + +E + GH W+++L E+ ++ ++ + D +L+ W + C E Sbjct: 1 MAVVYEGQLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPE 60 Query: 326 MSSKGAST-----ATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLG 380 +G S A ++G F + H + L G +C + Sbjct: 61 RRLEGHSAFVSDVALSNNGDFAVSASWDHSLRLWNLQTG--------------VCQHKF- 105 Query: 381 ISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGY 440 G TKDV + +SP +++ D R +++ G H R H Sbjct: 106 -LGHTKDVLSVTFSPDNRQIVSGGRDNALR-----VWNVKGE-----CLHTLGR-GAHTD 153 Query: 441 DMICVE---TVTDTRFVSGGDEKILRSFDLPKG 470 + CV ++ VSGG + +++ +D+ G Sbjct: 154 WVSCVRFSPSLETPLIVSGGWDNLVKVWDIASG 186 Score = 115 bits (287), Expect = 9e-26, Method: Composition-based stats. Identities = 61/374 (16%), Positives = 117/374 (31%), Gaps = 84/374 (22%) Query: 55 LKGHEAEVTCVRFVPD--SDFM--VSASEDHHVKIW------KFTDYSHLQCIQTIQHYS 104 LKGH VT + P ++ VS S D+ + W + + + ++ +S Sbjct: 9 LKGHRGWVTALA-CPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHS 67 Query: 105 KTI--VALSALPSLISVGCADGTISIWRQNIQNDE-FGLAHEFTIKKGFFYPLCLSLSKV 161 + VALS D ++ +W + L H + LS++ Sbjct: 68 AFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDV---------LSVTFS 118 Query: 162 EEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELE--GHEDWVKSLAFRHQETPGDY 219 + + +++ GG + + + + + L H DWV + F + Sbjct: 119 PDNRQIVS-GGRDNALRVWNVK--------GECLHTLGRGAHTDWVSCVRFSP--SLETP 167 Query: 220 LLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMG 279 L+ SG D +++W I L+ D + G Sbjct: 168 LIVSGGWDNLVKVWDIASGRLLTD---------------------------------LKG 194 Query: 280 HDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSG 339 H ++I+S+ ++ D +W+ + + + + Sbjct: 195 HTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPINQICFSP------N 248 Query: 340 GFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEY 399 +W C F L N K + S T + IAWS G Sbjct: 249 RYWMCAATEKGIRIFDLEN-KDVIVELAPEAQQK--------SKKTPECMSIAWSADGNT 299 Query: 400 LLATSLDQTTRLFA 413 L + D R+++ Sbjct: 300 LYSGYTDNVIRVWS 313 Score = 100 bits (248), Expect = 2e-21, Method: Composition-based stats. Identities = 43/238 (18%), Positives = 80/238 (33%), Gaps = 40/238 (16%) Query: 195 VAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW--RIRINDLIDDSEED----- 247 +L+GH WV +LA Q T S S+D + W + N + Sbjct: 6 EGQLKGHRGWVTALA-CPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLE 64 Query: 248 -----SKKLTLLSNKQYKFQIDDE-------LRVGINFEALIMGHDDWISSLQWHESRLQ 295 + L +N + + L+ G+ + GH + S+ + Q Sbjct: 65 GHSAFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFL-GHTKDVLSVTFSPDNRQ 123 Query: 296 LLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHER-MDF 354 +++ D +L VW GE + G+ + SC+ F+ Sbjct: 124 IVSGGRDNALRVWNVK------------GECL---HTLGRGAHTDWVSCVRFSPSLETPL 168 Query: 355 FLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLF 412 ++ G ++W + + G T +T + SP G ++ D RL+ Sbjct: 169 IVSGGWDNLVKVWDIASGRLLT---DLKGHTNYITSVTVSPDGSLCASSDKDGVARLW 223 Score = 94.2 bits (232), Expect = 2e-19, Method: Composition-based stats. Identities = 47/231 (20%), Positives = 81/231 (35%), Gaps = 21/231 (9%) Query: 10 IFIGANK-QTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFV 68 F+G K V+ ++IV+ G + +W+ + H V+CVRF Sbjct: 104 KFLGHTKDVLSVTFSPDNRQIVSGGRDNALRVWNVKGECLHTLGRG--AHTDWVSCVRFS 161 Query: 69 P--DSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTI 126 P ++ +VS D+ VK+W L ++ +Y ++ +S SL + DG Sbjct: 162 PSLETPLIVSGGWDNLVKVWDIASGRLLTDLKGHTNYITSV-TVSPDGSLCASSDKDGVA 220 Query: 127 SIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSD 186 +W +A I + F P +Y + T + I D Sbjct: 221 RLWDLTKGEALSEMAAGAPINQICFSP----------NRYWM-CAATEKGIRIFDLENKD 269 Query: 187 SGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRI 237 +E + S+A+ L SG D IR+W + Sbjct: 270 VIVELAPEAQQKSKKTPECMSIAWS----ADGNTLYSGYTDNVIRVWSVSE 316 Score = 83.4 bits (204), Expect = 4e-16, Method: Composition-based stats. Identities = 37/180 (20%), Positives = 63/180 (35%), Gaps = 17/180 (9%) Query: 553 KLYGHGFEIT---CLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPA---LPFHS 606 +L GH +T C I+ S R N + + E L HS Sbjct: 8 QLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHS 67 Query: 607 LTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEF 666 ++ + S +G F +S D LW + HT+ + ++P Sbjct: 68 AFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFL-----GHTKDVLSVTFSP--D 120 Query: 667 GNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLEN 726 V+ RD ++VW + E A HT V+ + S+ +++S G +N Sbjct: 121 NRQIVSGGRDNALRVWNVKGECLHTLGRGA---HTDWVSCVRFSPSLETP-LIVSGGWDN 176 Score = 66.5 bits (160), Expect = 5e-11, Method: Composition-based stats. Identities = 32/160 (20%), Positives = 64/160 (40%), Gaps = 14/160 (8%) Query: 552 EKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITR 611 +L GH ++ + +S + SA ++ +R+++ + + L H+ + Sbjct: 61 RRLEGHSAFVSDVALSNNGDFAVSASWDHS-----LRLWNLQTGVCQHKFL-GHTKDVLS 114 Query: 612 LKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFV 671 + FS D + ++S RD +W E L HT + ++P + V Sbjct: 115 VTFSPDNRQIVSGGRDNALRVWNVKGE----CLHTLGRGAHTDWVSCVRFSPSLETPLIV 170 Query: 672 TASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHD 711 + D VKVW A +L HT +T++++ Sbjct: 171 SGGWDNLVKVWDI----ASGRLLTDLKGHTNYITSVTVSP 206 Score = 64.5 bits (155), Expect = 2e-10, Method: Composition-based stats. Identities = 57/340 (16%), Positives = 118/340 (34%), Gaps = 60/340 (17%) Query: 356 LTNGKTGSWRMWATK-DNIICDQRLGIS-----GATKDVTDIAWSPSGEYLLATSLDQTT 409 ++ + + W + D + G G + V+D+A S +G++ ++ S D + Sbjct: 32 VSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAFVSDVALSNNGDFAVSASWDHSL 91 Query: 410 RLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVE-TVTDTRFVSGGDEKILRSFDLP 468 RL+ + H+F H D++ V + + + VSGG + LR +++ Sbjct: 92 RLW---------NLQTGVCQHKFL---GHTKDVLSVTFSPDNRQIVSGGRDNALRVWNVK 139 Query: 469 KGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITD 528 L + + S P++ GG + D Sbjct: 140 GECLHTLGRGAHTDWVSCVRFSPSLETPLI-----------------VSGGWDNLVKVWD 182 Query: 529 PLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIR 588 + L + L GH IT + +SPD L AS+ + + Sbjct: 183 -------------IASGRLLTD---LKGHTNYITSVTVSPDGSLCASSDKDGVARLW--D 224 Query: 589 IFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKN 648 + E E+ P I ++ FS + ++ + ++ +++ +D EL + Sbjct: 225 LTKGEALSEMAAGAP-----INQICFSPN-RYWMCAATEKGIRIFDLENKDVIVELAPEA 278 Query: 649 EKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEP 688 ++ + A GN + D ++VW + Sbjct: 279 QQKSKKTPECMSIAWSADGNTLYSGYTDNVIRVWSVSEHA 318 Score = 51.1 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 34/194 (17%), Positives = 69/194 (35%), Gaps = 29/194 (14%) Query: 556 GHGFEITCLDISP--DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLK 613 H ++C+ SP + LI S N V+ I L H+ IT + Sbjct: 150 AHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASGRLLTD------LKGHTNYITSVT 203 Query: 614 FSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTA 673 S DG S +D LW+ + E+ I ++P + ++ A Sbjct: 204 VSPDGSLCASSDKDGVARLWDLTKGEALSEM------AAGAPINQICFSPNRY---WMCA 254 Query: 674 SRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYS 733 + +K ++++ + + D ++E + + + S + + +G LYS Sbjct: 255 ATEKGIRIFDLENK---DVIVELAPEAQQK--------SKKTPECMSIAWSADGN-TLYS 302 Query: 734 YTLGKFELITQLNE 747 + ++E Sbjct: 303 GYTDNVIRVWSVSE 316 Score = 34.1 bits (76), Expect = 0.26, Method: Composition-based stats. Identities = 9/70 (12%), Positives = 29/70 (41%), Gaps = 4/70 (5%) Query: 27 KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVT----CVRFVPDSDFMVSASEDHH 82 + + K I ++D + A +++ T + + D + + S D+ Sbjct: 249 RYWMCAATEKGIRIFDLENKDVIVELAPEAQQKSKKTPECMSIAWSADGNTLYSGYTDNV 308 Query: 83 VKIWKFTDYS 92 +++W ++++ Sbjct: 309 IRVWSVSEHA 318 >3JAP-g nrPDB Length = 326 Score = 167 bits (422), Expect = 2e-41, Method: Composition-based stats. Identities = 55/304 (18%), Positives = 106/304 (34%), Gaps = 31/304 (10%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNK--GVYATLKGHEAEVTCVRFVPDSDFMVSASEDHH 82 + +V+ KT+ W E + + KGH V V D ++ VSAS D Sbjct: 30 QPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDVVVSADGNYAVSASWDKT 89 Query: 83 VKIWKFTDYSHLQCIQTIQHYSKTIVALSAL--PSLISVGCADGTISIWRQNIQNDEFGL 140 +++W + ++ +++++ S I D TI +W L Sbjct: 90 LRLWNLATGNSE---ARFVGHTGDVLSVAIDANSSKIISASRDKTIRVWNTVGDCAYVLL 146 Query: 141 AHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEG 200 H + K P L +V++ + G + V S + R+ A+ G Sbjct: 147 GHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWSL-----NEDSYRIEADFIG 201 Query: 201 HEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSK--KLTLLSNKQ 258 H +++ + Q +P L S +D I +W ++ + + + L ++ Sbjct: 202 HNNYINVV----QPSPDGSLAASAGKDGQIYVWNLKHKSAFMNFDAKDEVFALAFSPSRF 257 Query: 259 YKFQ----------IDDEL---RVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSL 305 + +++E+ + F D SL W L A D + Sbjct: 258 WLTAATASGIKIYDLENEVLIDELKPEFAGYTKAQDPHAVSLAWSADGQTLFAGYTDNVI 317 Query: 306 MVWE 309 VW+ Sbjct: 318 RVWQ 321 Score = 166 bits (420), Expect = 3e-41, Method: Composition-based stats. Identities = 54/210 (25%), Positives = 82/210 (39%), Gaps = 31/210 (14%) Query: 546 LLWPEVEKLYGHGFEITCLDISPDQ-KLIASACRSNNVQNAVIRIFSTENWLEIKPALP- 603 ++ L GH +T L S Q L+ S R +I TEN E + +P Sbjct: 6 IMLVLRGTLEGHNGWVTSLSTSAAQPNLLVSGSRD----KTLISWRLTEN--EQQFGVPV 59 Query: 604 ----FHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHT-RIIWD 658 HS + + S DG + +S D+ LW N+ E RF + D Sbjct: 60 RSYKGHSHIVQDVVVSADGNYAVSASWDKTLRLW--NLATGNSEARFVGHTGDVLSVAID 117 Query: 659 ADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKI 718 A+ + ++ASRDKT++VW + A + HT VT + + K Sbjct: 118 ANSSK------IISASRDKTIRVWNTVGDCA-----YVLLGHTDWVTKV-----RVAPKN 161 Query: 719 LISVGLENGEIYLYSYTLGKFELITQLNED 748 L +++G I S + K LNED Sbjct: 162 LEDGEVDDGRITFVSAGMDKIVRSWSLNED 191 Score = 99.2 bits (245), Expect = 6e-21, Method: Composition-based stats. Identities = 59/343 (17%), Positives = 117/343 (34%), Gaps = 64/343 (18%) Query: 99 TIQHYSKTIVALSAL---PSLISVGCADGTISIWRQNIQNDEFGL-AHEFTIKKGFFYPL 154 T++ ++ + +LS P+L+ G D T+ WR +FG+ + + Sbjct: 13 TLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDV 72 Query: 155 CLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQE 214 +S + Y ++ L + A GH V S+A Sbjct: 73 VVSA----DGNYAVSA--------SWDKTLRLWNLATGNSEARFVGHTGDVLSVAID--- 117 Query: 215 TPGDYLLCSGSQDRYIRLWR--------------------IRINDLIDDSEEDSKKLTLL 254 + S S+D+ IR+W + +L D +D + + Sbjct: 118 -ANSSKIISASRDKTIRVWNTVGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVS 176 Query: 255 SNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETS 314 + + EA +GH+++I+ +Q +A D + VW Sbjct: 177 AGMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWN----- 231 Query: 315 GIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNII 374 + K A + ++ F+ R F+LT +++ ++ ++ Sbjct: 232 -----------LKHKSAFMNFDAKDEVFALA-FSPSR--FWLTAATASGIKIYDLENEVL 277 Query: 375 CDQ-RLGISGATK----DVTDIAWSPSGEYLLATSLDQTTRLF 412 D+ + +G TK +AWS G+ L A D R++ Sbjct: 278 IDELKPEFAGYTKAQDPHAVSLAWSADGQTLFAGYTDNVIRVW 320 Score = 91.5 bits (225), Expect = 1e-18, Method: Composition-based stats. Identities = 46/245 (18%), Positives = 81/245 (33%), Gaps = 32/245 (13%) Query: 8 EAIFIGAN-KQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVR 66 EA F+G V+ KI++ KTI +W+ + + GH VT VR Sbjct: 101 EARFVGHTGDVLSVAIDANSSKIISASRDKTIRVWNTVGDCAYVLL----GHTDWVTKVR 156 Query: 67 FVP---------DSDF-MVSASEDHHVKIWKFTDYSHLQCIQTIQHYSK--TIVALSALP 114 P D VSA D V+ W + + ++ +V S Sbjct: 157 VAPKNLEDGEVDDGRITFVSAGMDKIVRSWSL-NEDSYRIEADFIGHNNYINVVQPSPDG 215 Query: 115 SLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTN 174 SL + DG I +W H+ +L+ + +L A + Sbjct: 216 SLAASAGKDGQIYVWNLK---------HKSAFMNFDAKDEVFALAFSPSRFWLTAATASG 266 Query: 175 VNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWR 234 + ++ + ++ E G+ A + L +G D IR+W+ Sbjct: 267 IKIYDLENEVLIDELKP-----EFAGYTKAQDPHAVSLAWSADGQTLFAGYTDNVIRVWQ 321 Query: 235 IRIND 239 + + Sbjct: 322 VMTAN 326 Score = 89.2 bits (219), Expect = 7e-18, Method: Composition-based stats. Identities = 69/385 (17%), Positives = 127/385 (32%), Gaps = 88/385 (22%) Query: 274 EALIMGHDDWISSLQWHESRL-QLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGAS 332 + GH+ W++SL ++ L++ + D +L+ W E + S KG S Sbjct: 11 RGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQ----QFGVPVRSYKGHS 66 Query: 333 TATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIA 392 + ++ + R+W + G T DV +A Sbjct: 67 HI---VQDVVVSADGNYA-----VSASWDKTLRLWNLATG---NSEARFVGHTGDVLSVA 115 Query: 393 WSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVE------ 446 + +++ S D+T R +++ G + H + V Sbjct: 116 IDANSSKIISASRDKTIR-----VWNTVGDCAYVLL--------GHTDWVTKVRVAPKNL 162 Query: 447 ---TVTDTR--FVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLS 501 V D R FVS G +KI+RS+ L + + F+G P P L+ Sbjct: 163 EDGEVDDGRITFVSAGMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQPS----PDGSLA 218 Query: 502 NKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEI 561 AG+D G ++ + + + E+ Sbjct: 219 ASAGKD-----------GQIYVWNLKHKSAFMNFDAKD--------------------EV 247 Query: 562 TCLDISPDQKLIASACRSNNVQNAVIRIFSTENWL---EIKPALPFHSL----TITRLKF 614 L SP + + +A S I+I+ EN + E+KP ++ L + Sbjct: 248 FALAFSPSRFWLTAATASG------IKIYDLENEVLIDELKPEFAGYTKAQDPHAVSLAW 301 Query: 615 SKDGKFLLSVCRDRKWALWERNMED 639 S DG+ L + D +W+ + Sbjct: 302 SADGQTLFAGYTDNVIRVWQVMTAN 326 Score = 84.6 bits (207), Expect = 2e-16, Method: Composition-based stats. Identities = 41/279 (14%), Positives = 81/279 (29%), Gaps = 50/279 (17%) Query: 134 QNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCR 193 + L T++ + LS S + LL G + + ++ Sbjct: 2 SSSNIMLVLRGTLEGHNGWVTSLSTSAAQPN--LLVSGSRDKTLISWRLTENEQQF--GV 57 Query: 194 VVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTL 253 V +GH V+ + S S D+ +RLW + Sbjct: 58 PVRSYKGHSHIVQDVVVS----ADGNYAVSASWDKTLRLWNLATG--------------- 98 Query: 254 LSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDET 313 N EA +GH + S+ + ++++A+ D ++ VW Sbjct: 99 ------------------NSEARFVGHTGDVLSVAIDANSSKIISASRDKTIRVWN-TVG 139 Query: 314 SGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNI 373 +V L + +K G + F++ G R W+ ++ Sbjct: 140 DCAYVL-LGHTDWVTKVRVAPKNLEDGEV------DDGRITFVSAGMDKIVRSWSLNEDS 192 Query: 374 ICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLF 412 G + + SP G + D ++ Sbjct: 193 Y-RIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVW 230 Score = 48.7 bits (114), Expect = 1e-05, Method: Composition-based stats. Identities = 66/392 (16%), Positives = 125/392 (31%), Gaps = 86/392 (21%) Query: 369 TKDNIICDQRLGISGATKDVTDIAWSPSG-EYLLATSLDQTTRLFAPWIYDASGRKREIA 427 + NI+ R + G VT ++ S + L++ S D+T + ++ Sbjct: 2 SSSNIMLVLRGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRL----TENEQQFGV 57 Query: 428 TWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKS 487 + D+ V + VS +K LR ++L G + +FVG Sbjct: 58 PVRSYKGHSHIVQDV--VVSADGNYAVSASWDKTLRLWNLATGNSE--ARFVG------- 106 Query: 488 EMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLL 547 D +V + DAN S + + ++ + Sbjct: 107 HTGDVLSVAI----------DANS-------------------SKIISASRDKTIR---V 134 Query: 548 WPEV----EKLYGHGFEITCLDISPDQ----------KLIASACRSNNVQNAVIRIFSTE 593 W V L GH +T + ++P SA V++ + E Sbjct: 135 WNTVGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWSLN----E 190 Query: 594 NWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHT 653 + I+ H+ I ++ S DG S +D + +W + K+E Sbjct: 191 DSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMNFDAKDE---- 246 Query: 654 RIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSM 713 ++ ++P F TAS +K++ + E D + +TKA Sbjct: 247 --VFALAFSPSRFWLTAATAS---GIKIYDLENEVLIDELKPEFAGYTKA---------- 291 Query: 714 IREKILISVGLENGEIYLYSYTLGKFELITQL 745 + +G+ YT + Q+ Sbjct: 292 QDPHAVSLAWSADGQTLFAGYT-DNVIRVWQV 322 >3JRP-A nrPDB Length = 379 Score = 166 bits (420), Expect = 3e-41, Method: Composition-based stats. Identities = 61/272 (22%), Positives = 107/272 (39%), Gaps = 25/272 (9%) Query: 26 VKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPD--SDFMVSASEDHHV 83 K++ + KTI +++ E + TL GHE V V + + S S D V Sbjct: 23 GKRLATCSSDKTIKIFEV-EGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKV 81 Query: 84 KIWKFTDYSHLQCIQTIQHYSKTIVALSALP----SLISVGCADGTISI--WRQNIQNDE 137 IWK + Q I +S ++ ++ P L+ V +DG +S+ +++N Sbjct: 82 LIWKEENGRWSQ-IAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSP 140 Query: 138 FGL-AHEFTIKKGFFYPLCLSLSKVEEK---KYLLAIGGTNVNVFIASFILSDSGIEKCR 193 + AH + + P + GG + V I + +S + Sbjct: 141 IIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY---NSDAQTYV 197 Query: 194 VVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTL 253 + + LEGH DWV+ +A+ Y L S SQDR +W D+E+ K TL Sbjct: 198 LESTLEGHSDWVRDVAWSPTVLLRSY-LASVSQDRTCIIW-------TQDNEQGPWKKTL 249 Query: 254 LSNKQYKFQIDDELRVGINFEALIMGHDDWIS 285 L +++ + + G D+ ++ Sbjct: 250 LKEEKFPDVLWRASWSLSGNVLALSGGDNKVT 281 Score = 59.5 bits (142), Expect = 5e-09, Method: Composition-based stats. Identities = 50/229 (21%), Positives = 87/229 (37%), Gaps = 25/229 (10%) Query: 551 VEKLYGHGFEITCLD-ISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPAL-PFHSLT 608 ++ L GH + +D P I ++C + + I+ EN + A+ HS + Sbjct: 48 IDTLTGHEGPVWRVDWAHPKFGTILASCSY----DGKVLIWKEENGRWSQIAVHAVHSAS 103 Query: 609 ITRLKFSKD--GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAP--- 663 + ++++ G LL D K ++ E T + A WAP Sbjct: 104 VNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVN---SASWAPATI 160 Query: 664 --------LEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASI-KHTKAVTAISIHDSMI 714 + FVT D VK+W++ + A YVLE+++ H+ V ++ +++ Sbjct: 161 EEDGEHNGTKESRKFVTGGADNLVKIWKYNSD-AQTYVLESTLEGHSDWVRDVAWSPTVL 219 Query: 715 REKILISVGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHL 763 L SV + I T L E+ P D + R WS Sbjct: 220 LRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFP-DVLWRASWSLS 267 Score = 54.1 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 23/115 (20%), Positives = 47/115 (40%), Gaps = 8/115 (6%) Query: 575 SACRSNNVQNAVIRIFSTENWLEIKP---ALPFHSLTITRLKFSKD---GKFLLSVCRDR 628 S + +++I+ + + L HS + + +S +L SV +DR Sbjct: 172 SRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDR 231 Query: 629 KWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWR 683 +W ++ E ++ E+ ++W A W+ GNV + D V +W+ Sbjct: 232 TCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWS--LSGNVLALSGGDNKVTLWK 284 Score = 51.8 bits (122), Expect = 1e-06, Method: Composition-based stats. Identities = 33/199 (16%), Positives = 65/199 (32%), Gaps = 32/199 (16%) Query: 279 GHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSS 338 H++ I +L ++D ++ ++E + + + +L TG Sbjct: 9 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTL-------------TGHE 55 Query: 339 GGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPS-- 396 G W W + + G +W ++ + + V + W+P Sbjct: 56 GPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAV-HSASVNSVQWAPHEY 114 Query: 397 GEYLLATSLDQTTRLF--------APWIYDASGRKREIATWH--EFSRPQIHGYDMICVE 446 G LL S D + +P I DA A+W H Sbjct: 115 GPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNG------ 168 Query: 447 TVTDTRFVSGGDEKILRSF 465 T +FV+GG + +++ + Sbjct: 169 TKESRKFVTGGADNLVKIW 187 Score = 35.6 bits (80), Expect = 0.080, Method: Composition-based stats. Identities = 46/296 (15%), Positives = 97/296 (32%), Gaps = 45/296 (15%) Query: 355 FLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPS--GEYLLATSLDQTTRLF 412 T + +++ + ++G V + W+ G L + S D ++ Sbjct: 26 LATCSSDKTIKIFEVEGETHKLID-TLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIW 84 Query: 413 APWIYDASGRKREIATWHEFSRPQIHGYDMICVETVT---DTRFVSGGDEKILRSFDLPK 469 K E W + + +H + V+ + + + Sbjct: 85 ----------KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV----- 129 Query: 470 GVAGMLQKFVGIQFEEK-SEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITD 528 ++F+E + P +G+ N A A +++ E G KE+ Sbjct: 130 -----------VEFKENGTTSPIIIDAHAIGV-NSASWAPATIEEDGEHNGTKESRKFVT 177 Query: 529 PLS--LLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAV 586 + L++ Q ++L L GH + + SP ++ + ++ Q+ Sbjct: 178 GGADNLVKIWKYNSDAQTYVL---ESTLEGHSDWVRDVAWSP--TVLLRSYLASVSQDRT 232 Query: 587 IRIFSTEN----WLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNME 638 I++ +N W + + R +S G L D K LW+ N+E Sbjct: 233 CIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLE 288 >4BZK-B nrPDB Length = 297 Score = 162 bits (410), Expect = 4e-40, Method: Composition-based stats. Identities = 61/272 (22%), Positives = 107/272 (39%), Gaps = 25/272 (9%) Query: 26 VKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPD--SDFMVSASEDHHV 83 K++ + KTI +++ E + TL GHE V V + + S S D V Sbjct: 21 GKRLATCSSDKTIKIFEV-EGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKV 79 Query: 84 KIWKFTDYSHLQCIQTIQHYSKTIVALSALP----SLISVGCADGTISI--WRQNIQNDE 137 IWK + Q I +S ++ ++ P L+ V +DG +S+ +++N Sbjct: 80 LIWKEENGRWSQ-IAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSP 138 Query: 138 FGL-AHEFTIKKGFFYPLCLSLSKVEEK---KYLLAIGGTNVNVFIASFILSDSGIEKCR 193 + AH + + P + GG + V I + +S + Sbjct: 139 IIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY---NSDAQTYV 195 Query: 194 VVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTL 253 + + LEGH DWV+ +A+ Y L S SQDR +W D+E+ K TL Sbjct: 196 LESTLEGHSDWVRDVAWSPTVLLRSY-LASVSQDRTCIIW-------TQDNEQGPWKKTL 247 Query: 254 LSNKQYKFQIDDELRVGINFEALIMGHDDWIS 285 L +++ + + G D+ ++ Sbjct: 248 LKEEKFPDVLWRASWSLSGNVLALSGGDNKVT 279 Score = 58.0 bits (138), Expect = 2e-08, Method: Composition-based stats. Identities = 50/229 (21%), Positives = 87/229 (37%), Gaps = 25/229 (10%) Query: 551 VEKLYGHGFEITCLD-ISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPAL-PFHSLT 608 ++ L GH + +D P I ++C + + I+ EN + A+ HS + Sbjct: 46 IDTLTGHEGPVWRVDWAHPKFGTILASCSY----DGKVLIWKEENGRWSQIAVHAVHSAS 101 Query: 609 ITRLKFSKD--GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAP--- 663 + ++++ G LL D K ++ E T + A WAP Sbjct: 102 VNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVN---SASWAPATI 158 Query: 664 --------LEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASI-KHTKAVTAISIHDSMI 714 + FVT D VK+W++ + A YVLE+++ H+ V ++ +++ Sbjct: 159 EEDGEHNGTKESRKFVTGGADNLVKIWKYNSD-AQTYVLESTLEGHSDWVRDVAWSPTVL 217 Query: 715 REKILISVGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHL 763 L SV + I T L E+ P D + R WS Sbjct: 218 LRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFP-DVLWRASWSLS 265 Score = 53.0 bits (125), Expect = 5e-07, Method: Composition-based stats. Identities = 23/115 (20%), Positives = 47/115 (40%), Gaps = 8/115 (6%) Query: 575 SACRSNNVQNAVIRIFSTENWLEIKP---ALPFHSLTITRLKFSKD---GKFLLSVCRDR 628 S + +++I+ + + L HS + + +S +L SV +DR Sbjct: 170 SRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDR 229 Query: 629 KWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWR 683 +W ++ E ++ E+ ++W A W+ GNV + D V +W+ Sbjct: 230 TCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWS--LSGNVLALSGGDNKVTLWK 282 Score = 49.9 bits (117), Expect = 4e-06, Method: Composition-based stats. Identities = 33/199 (16%), Positives = 65/199 (32%), Gaps = 32/199 (16%) Query: 279 GHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSS 338 H++ I +L ++D ++ ++E + + + +L TG Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTL-------------TGHE 53 Query: 339 GGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPS-- 396 G W W + + G +W ++ + + V + W+P Sbjct: 54 GPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAV-HSASVNSVQWAPHEY 112 Query: 397 GEYLLATSLDQTTRLF--------APWIYDASGRKREIATWH--EFSRPQIHGYDMICVE 446 G LL S D + +P I DA A+W H Sbjct: 113 GPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNG------ 166 Query: 447 TVTDTRFVSGGDEKILRSF 465 T +FV+GG + +++ + Sbjct: 167 TKESRKFVTGGADNLVKIW 185 Score = 34.1 bits (76), Expect = 0.27, Method: Composition-based stats. Identities = 46/296 (15%), Positives = 97/296 (32%), Gaps = 45/296 (15%) Query: 355 FLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPS--GEYLLATSLDQTTRLF 412 T + +++ + ++G V + W+ G L + S D ++ Sbjct: 24 LATCSSDKTIKIFEVEGETHKLID-TLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIW 82 Query: 413 APWIYDASGRKREIATWHEFSRPQIHGYDMICVETVT---DTRFVSGGDEKILRSFDLPK 469 K E W + + +H + V+ + + + Sbjct: 83 ----------KEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV----- 127 Query: 470 GVAGMLQKFVGIQFEEK-SEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITD 528 ++F+E + P +G+ N A A +++ E G KE+ Sbjct: 128 -----------VEFKENGTTSPIIIDAHAIGV-NSASWAPATIEEDGEHNGTKESRKFVT 175 Query: 529 PLS--LLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAV 586 + L++ Q ++L L GH + + SP ++ + ++ Q+ Sbjct: 176 GGADNLVKIWKYNSDAQTYVL---ESTLEGHSDWVRDVAWSP--TVLLRSYLASVSQDRT 230 Query: 587 IRIFSTEN----WLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNME 638 I++ +N W + + R +S G L D K LW+ N+E Sbjct: 231 CIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLE 286 >3FM0-A nrPDB Length = 345 Score = 160 bits (403), Expect = 3e-39, Method: Composition-based stats. Identities = 67/349 (19%), Positives = 123/349 (35%), Gaps = 52/349 (14%) Query: 26 VKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKI 85 + + G + I +W + +GH+ V V + P +++ SAS D I Sbjct: 28 GTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCI 87 Query: 86 WKFTDYSHLQCIQTIQHYSKTIVALSALPS--LISVGCADGTISIWRQNIQNDEFGLA-- 141 WK + +C+ T++ + + +++ PS L++ D ++ +W + + DE+ Sbjct: 88 WK-KNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVD-EEDEYECVSV 145 Query: 142 ---HEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAEL 198 H +K ++P + LLA + V + D A L Sbjct: 146 LNSHTQDVKHVVWHPS----------QELLASASYDDTVKLYREEEDDW-----VCCATL 190 Query: 199 EGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQ 258 EGHE V SLAF P L S S DR +R+WR + +E+ + + Sbjct: 191 EGHESTVWSLAFD----PSGQRLASCSDDRTVRIWR----QYLPGNEQGVACSGSDPSWK 242 Query: 259 YKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWV 318 + H I + W + L A D ++ V++ D S Sbjct: 243 CICTLSGF-------------HSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQ 289 Query: 319 CSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMW 367 + L + S +C+ + + + G W Sbjct: 290 PTFSLTAHLHQAHSQD-------VNCVAWNPKEPGLLASCSDDGEVAFW 331 Score = 143 bits (361), Expect = 2e-34, Method: Composition-based stats. Identities = 55/216 (25%), Positives = 88/216 (40%), Gaps = 35/216 (16%) Query: 564 LDISPDQKLIASACRSNNVQNAVIRIFSTEN--WLEIKPALPFHSLTITRLKFSKDGKFL 621 L +P L+AS + IRI+ TE W+ H T+ ++ +S G +L Sbjct: 22 LAWNPAGTLLASCG-----GDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYL 76 Query: 622 LSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKV 681 S D +W++N +D FE E H + WAP GN+ T SRDK+V V Sbjct: 77 ASASFDATTCIWKKNQDD--FECVTTLE-GHENEVKSVAWAP--SGNLLATCSRDKSVWV 131 Query: 682 WRHQKEPADDYVLEASIK-HTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKFE 740 W +E D+Y + + HT+ V + H S +++L S ++ + LY + Sbjct: 132 WEVDEE--DEYECVSVLNSHTQDVKHVVWHPS---QELLASASYDD-TVKLYREEEDDWV 185 Query: 741 L----------ITQLNEDITP------ADKITRLRW 760 + L D + +D T W Sbjct: 186 CCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221 Score = 116 bits (291), Expect = 3e-26, Method: Composition-based stats. Identities = 49/303 (16%), Positives = 108/303 (35%), Gaps = 48/303 (15%) Query: 26 VKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKI 85 + + T +W + ++ TL+GHE EV V + P + + + S D V + Sbjct: 73 GNYLASASFDATTCIWKKNQ-DDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWV 131 Query: 86 WKFTDYSHLQCIQTIQHYSKTIVALSALPS--LISVGCADGTISIWRQNIQNDEFGLAHE 143 W+ + +C+ + +++ + + PS L++ D T+ ++R+ + D++ Sbjct: 132 WEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYRE--EEDDWVCCAT 189 Query: 144 FTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIE--------KCRVV 195 + + SL+ + L + + V I L + + + Sbjct: 190 LEGHESTVW----SLAFDPSGQRLASC-SDDRTVRIWRQYLPGNEQGVACSGSDPSWKCI 244 Query: 196 AELEG-HEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLL 254 L G H + +A+ L + D IR+++ +D D ++ T Sbjct: 245 CTLSGFHSRTIYDIAWCQLTGA----LATACGDDAIRVFQ-------EDPNSDPQQPTFS 293 Query: 255 SNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAA-TADTSLMVWEPDET 313 L H ++ + W+ LLA+ + D + W+ Sbjct: 294 LTAH-----------------LHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQRP 336 Query: 314 SGI 316 G+ Sbjct: 337 EGL 339 Score = 109 bits (271), Expect = 5e-24, Method: Composition-based stats. Identities = 58/372 (15%), Positives = 120/372 (32%), Gaps = 60/372 (16%) Query: 46 PNNKGVYATLKGHEA-EVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYS 104 ++ + + H + + P + S D ++IW S + + + Sbjct: 2 KDSLVLLGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQ 61 Query: 105 KTIVALSALP--SLISVGCADGTISIWR---QNIQNDEFGLAHEFTIKKGFFYPLCLSLS 159 +T+ ++ P + ++ D T IW+ + + HE +K + P Sbjct: 62 RTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPS----- 116 Query: 160 KVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDY 219 LLA + +V++ D + V+ L H VK + + + Sbjct: 117 -----GNLLATCSRDKSVWVWEVDEED----EYECVSVLNSHTQDVKHVVWHPSQE---- 163 Query: 220 LLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMG 279 LL S S D ++L+R +D + A + G Sbjct: 164 LLASASYDDTVKLYREEEDDWVC-------------------------------CATLEG 192 Query: 280 HDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSG 339 H+ + SL + S +L + + D ++ +W + + S K T +G Sbjct: 193 HESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHS 252 Query: 340 GFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGIS-----GATKDVTDIAWS 394 + + G ++ ++ ++DV +AW+ Sbjct: 253 RTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWN 312 Query: 395 PSGEYLLATSLD 406 P LLA+ D Sbjct: 313 PKEPGLLASCSD 324 Score = 90.3 bits (222), Expect = 3e-18, Method: Composition-based stats. Identities = 65/364 (17%), Positives = 113/364 (31%), Gaps = 84/364 (23%) Query: 99 TIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQ----NDEFGLAHEFTIKKGFFYPL 154 +A + +L++ D I IW H+ T++K + P Sbjct: 13 AHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSP- 71 Query: 155 CLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQE 214 LA + I D V LEGHE+ VKS+A+ Sbjct: 72 ---------CGNYLASASFDATTCIWKKNQDDFE-----CVTTLEGHENEVKSVAWA--- 114 Query: 215 TPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFE 274 P LL + S+D+ + +W + D Sbjct: 115 -PSGNLLATCSRDKSVWVWEVDEEDEY------------------------------ECV 143 Query: 275 ALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTA 334 +++ H + + WH S+ L +A+ D ++ ++ +E WVC +T Sbjct: 144 SVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDD--WVC-----------CATL 190 Query: 335 TGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMW-----ATKDNIICDQR-------LGIS 382 G WS + + + R+W + + C +S Sbjct: 191 EGHESTVWSLAF--DPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLS 248 Query: 383 G-ATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYD 441 G ++ + DIAW L D R+F D + ++ Q H D Sbjct: 249 GFHSRTIYDIAWCQLTGALATACGDDAIRVFQE---DPNSDPQQPTFSLTAHLHQAHSQD 305 Query: 442 MICV 445 + CV Sbjct: 306 VNCV 309 Score = 83.4 bits (204), Expect = 3e-16, Method: Composition-based stats. Identities = 54/307 (17%), Positives = 96/307 (31%), Gaps = 62/307 (20%) Query: 162 EEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLL 221 LLA G + + I + EGH+ V+ +A+ P L Sbjct: 25 NPAGTLLASCGGDRRIRIWGTEGDSWICKSVLS----EGHQRTVRKVAWS----PCGNYL 76 Query: 222 CSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHD 281 S S D +W+ +D + GH+ Sbjct: 77 ASASFDATTCIWKKNQDDFEC-------------------------------VTTLEGHE 105 Query: 282 DWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGF 341 + + S+ W S L + D S+ VWE DE + S + Sbjct: 106 NEVKSVAWAPSGNLLATCSRDKSVWVWEVDEED------------EYECVSVLNSHTQDV 153 Query: 342 WSCLWFTHERMDFFLTNGKTGSWRMW-ATKDNIICDQRLGISGATKDVTDIAWSPSGEYL 400 +W H + + + +++ +D+ +C + G V +A+ PSG+ L Sbjct: 154 KHVVW--HPSQELLASASYDDTVKLYREEEDDWVCCA--TLEGHESTVWSLAFDPSGQRL 209 Query: 401 LATSLDQTTRLFAPWI------YDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFV 454 + S D+T R++ ++ SG S I +T Sbjct: 210 ASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALAT 269 Query: 455 SGGDEKI 461 + GD+ I Sbjct: 270 ACGDDAI 276 Score = 79.2 bits (193), Expect = 7e-15, Method: Composition-based stats. Identities = 63/360 (17%), Positives = 117/360 (32%), Gaps = 59/360 (16%) Query: 342 WSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLL 401 W W + + G R+W T+ + + + G + V +AWSP G YL Sbjct: 20 WFLAW--NPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLA 77 Query: 402 ATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVE-TVTDTRFVSGGDEK 460 + S D TT ++ + + + H ++ V + + +K Sbjct: 78 SASFDATTCIW-------KKNQDDFECVTTL---EGHENEVKSVAWAPSGNLLATCSRDK 127 Query: 461 ILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGN 520 + +++ + + V + ++ P L A DD + EEE Sbjct: 128 SVWVWEVDEEDE---YECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDD- 183 Query: 521 KETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSN 580 W L GH + L P + +AS Sbjct: 184 ---------------------------WVCCATLEGHESTVWSLAFDPSGQRLASCSDDR 216 Query: 581 NVQNAVIRIFSTE----------NWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKW 630 V+ + E +W I FHS TI + + + L + C D Sbjct: 217 TVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAI 276 Query: 631 ALWE----RNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQK 686 +++ + + TF L + H++ + W P E + + S D V W++Q+ Sbjct: 277 RVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKE-PGLLASCSDDGEVAFWKYQR 335 Score = 73.4 bits (178), Expect = 3e-13, Method: Composition-based stats. Identities = 35/161 (21%), Positives = 61/161 (37%), Gaps = 10/161 (6%) Query: 555 YGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKF 614 GH + + SP +ASA ++ E L H + + + Sbjct: 58 EGHQRTVRKVAWSPCGNYLASASFDA----TTCIWKKNQDDFECVTTLEGHENEVKSVAW 113 Query: 615 SKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTAS 674 + G L + RD+ +WE + ED +E HT+ + W P + +AS Sbjct: 114 APSGNLLATCSRDKSVWVWEVDEEDE-YECVSVLNS-HTQDVKHVVWHP--SQELLASAS 169 Query: 675 RDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIR 715 D TVK++R +++ D H V +++ S R Sbjct: 170 YDDTVKLYREEED--DWVCCATLEGHESTVWSLAFDPSGQR 208 Score = 67.6 bits (163), Expect = 2e-11, Method: Composition-based stats. Identities = 40/201 (19%), Positives = 74/201 (36%), Gaps = 25/201 (12%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 V L H ++ + P Q+L+ASA + V E+ L H T+ Sbjct: 143 VSVLNSHTQDVKHVVWHPSQELLASASYD----DTVKLYREEEDDWVCCATLEGHESTVW 198 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNM-----------EDNTFELRFKNEKPHTRIIWDA 659 L F G+ L S DR +W + + D +++ H+R I+D Sbjct: 199 SLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDI 258 Query: 660 DWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASI-----KHTKAVTAISIHDSMI 714 W L TA D ++V++ + H++ V ++ + Sbjct: 259 AWCQLTGA--LATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNP--- 313 Query: 715 REKILISVGLENGEIYLYSYT 735 +E L++ ++GE+ + Y Sbjct: 314 KEPGLLASCSDDGEVAFWKYQ 334 Score = 61.8 bits (148), Expect = 1e-09, Method: Composition-based stats. Identities = 19/128 (14%), Positives = 48/128 (37%), Gaps = 22/128 (17%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNK------------GVYATLKG-HEAEVTCVRFVPDS 71 +++ + +T+ +W P N+ TL G H + + + + Sbjct: 205 SGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLT 264 Query: 72 DFMVSASEDHHVKIWKFTDYSHLQ------CIQTIQHYSKTIVALSALPS---LISVGCA 122 + +A D +++++ S Q Q +S+ + ++ P L++ Sbjct: 265 GALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSD 324 Query: 123 DGTISIWR 130 DG ++ W+ Sbjct: 325 DGEVAFWK 332 >5K1B-B nrPDB Length = 677 Score = 159 bits (402), Expect = 4e-39, Method: Composition-based stats. Identities = 54/251 (21%), Positives = 91/251 (36%), Gaps = 21/251 (8%) Query: 15 NKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFM 74 N + + ++ G I +W + A+++ H V + + + Sbjct: 31 NGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTL 90 Query: 75 VSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQ 134 +SAS D VK+W + ++T + Y K + A + L++ D I +W N Sbjct: 91 ISASSDTTVKVWNAHKGFCMSTLRTHKDYVKAL-AYAKDKELVASAGLDRQIFLWDVNTL 149 Query: 135 NDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIG--GTNVNVFIASFILSDSGIEKC 192 + T SLS ++ Y LA+ GT + +L C Sbjct: 150 TALTASNNTVT---------TSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTC 200 Query: 193 RVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI---RINDLIDDSEEDSK 249 + +L+GH D VK+L T SGS D IRLW + R +E Sbjct: 201 AKLMKLKGHTDNVKALLLNRDGTQ----CLSGSSDGTIRLWSLGQQRCIATYRVHDEGVW 256 Query: 250 KLTLLSNKQYK 260 L + N + Sbjct: 257 ALQV--NDAFT 265 Score = 92.3 bits (227), Expect = 7e-19, Method: Composition-based stats. Identities = 51/299 (17%), Positives = 107/299 (35%), Gaps = 65/299 (21%) Query: 170 IGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRY 229 G + + I S +A +E H DWV + L S S D Sbjct: 47 TAGRDSIIRIWSVNQHKQDP----YIASMEHHTDWVNDIVLCC----NGKTLISASSDTT 98 Query: 230 IRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQW 289 +++W +K LR H D++ +L + Sbjct: 99 VKVWN-----------------------AHKGFCMSTLRT----------HKDYVKALAY 125 Query: 290 HESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTH 349 + + + +A D + +W+ + + + + ++ S+ +G+ +S + Sbjct: 126 AKDKELVASAGLDRQIFLWDVNTLTALTASN------NTVTTSSLSGNKDSIYSLAM--N 177 Query: 350 ERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTT 409 + ++ R+W + C + + + G T +V + + G L+ S D T Sbjct: 178 QLGTIIVSGSTEKVLRVWDPRT---CAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTI 234 Query: 410 RLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTD-TRFVSGGDEKILRSFDL 467 RL++ G++R IAT+ ++H + ++ T SGG ++ + DL Sbjct: 235 RLWSL------GQQRCIATY------RVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDL 281 Score = 59.1 bits (141), Expect = 7e-09, Method: Composition-based stats. Identities = 34/228 (14%), Positives = 81/228 (35%), Gaps = 39/228 (17%) Query: 561 ITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIK--PALPFHSLTITRLKFSKDG 618 + L + P + +A R +++IRI+S + ++ H+ + + +G Sbjct: 33 VNALQLDPALNRLFTAGR-----DSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNG 87 Query: 619 KFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKT 678 K L+S D +W + LR + A + + +A D+ Sbjct: 88 KTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVK-------ALAYAKDKELVASAGLDRQ 140 Query: 679 VKVWRHQK----EPADDYVLEASI-KHTKAVTAISIHDSMIREKILISVGLEN------- 726 + +W +++ V +S+ + ++ +++++ I++S E Sbjct: 141 IFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGT---IIVSGSTEKVLRVWDP 197 Query: 727 ----GEIYLYSYTLGKFELITQLNED----ITPADKITRLRWSHLKRN 766 + L +T LN D ++ + T WS ++ Sbjct: 198 RTCAKLMKLKGHTDN--VKALLLNRDGTQCLSGSSDGTIRLWSLGQQR 243 Score = 58.0 bits (138), Expect = 2e-08, Method: Composition-based stats. Identities = 45/305 (14%), Positives = 88/305 (28%), Gaps = 46/305 (15%) Query: 388 VTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMI-CVE 446 V + P+ L D R+++ + + IA+ H + V Sbjct: 33 VNALQLDPALNRLFTAGRDSIIRIWSV---NQHKQDPYIASMEH------HTDWVNDIVL 83 Query: 447 TVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGE 506 +S + ++ ++ KG + + + D V GL + Sbjct: 84 CCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFL 143 Query: 507 DDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDI 566 D N N T L G+ I L + Sbjct: 144 WDVNTLTALTASNNTVT---------------------------TSSLSGNKDSIYSLAM 176 Query: 567 SPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCR 626 + +I S V+R++ L H+ + L ++DG LS Sbjct: 177 NQLGTIIVSGS-----TEKVLRVWDPRT-CAKLMKLKGHTDNVKALLLNRDGTQCLSGSS 230 Query: 627 DRKWALWERNMEDNTFELRFKNEKPHTRIIWDA---DWAPLEFGNVFVTASRDKTVKVWR 683 D LW + R +E + DA ++ ++ T R+ ++V Sbjct: 231 DGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLI 290 Query: 684 HQKEP 688 +++ Sbjct: 291 CEEKA 295 Score = 51.8 bits (122), Expect = 1e-06, Method: Composition-based stats. Identities = 47/283 (16%), Positives = 91/283 (32%), Gaps = 46/283 (16%) Query: 349 HERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQT 408 ++ T G+ R+W+ + + T V DI +G+ L++ S D T Sbjct: 39 DPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTT 98 Query: 409 TRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFV-SGGDEKILRSFDL 467 + +++A + + H + + D V S G ++ + +D+ Sbjct: 99 VK-----VWNA----HKGFCMSTL---RTHKDYVKALAYAKDKELVASAGLDRQIFLWDV 146 Query: 468 PKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDIT 527 A +A+ + S+ +G D+ + G T Sbjct: 147 NTLTA------------------LTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGST 188 Query: 528 DPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVI 587 + + + P +L KL GH + L ++ D S I Sbjct: 189 EKVLRVWDPRTCAKLM---------KLKGHTDNVKALLLNRDGTQCLSGSSDGT-----I 234 Query: 588 RIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKW 630 R++S I H + L+ + + S RDRK Sbjct: 235 RLWSLGQQRCI-ATYRVHDEGVWALQVNDAFTHVYSGGRDRKI 276 Score = 51.4 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 17/120 (14%), Positives = 37/120 (30%), Gaps = 5/120 (4%) Query: 15 NKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFM 74 + + + ++ + TI LW + + AT + H+ V ++ + Sbjct: 211 DNVKALLLNRDGTQCLSGSSDGTIRLWSLGQ---QRCIATYRVHDEGVWALQVNDAFTHV 267 Query: 75 VSASEDHHVKIWKFTDY--SHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQN 132 S D + + L C + + + P I V T++ W Sbjct: 268 YSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDRSADPPPAIWVATTKSTVNKWTLK 327 >6EMK-B nrPDB Length = 303 Score = 157 bits (397), Expect = 1e-38, Method: Composition-based stats. Identities = 59/303 (19%), Positives = 108/303 (35%), Gaps = 52/303 (17%) Query: 14 ANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDF 73 ++ Q +I KK++A + + L+D I N A+ +GH VT V F D+ + Sbjct: 31 SDSQVNRLEITNDKKLLATAGHQNVRLYD-IRTTNPNPVASFEGHRGNVTSVSFQQDNRW 89 Query: 74 MVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSL--ISVGCADGTISIWRQ 131 MV++SED +K+W S I ++ + + P+ + DG I IW Sbjct: 90 MVTSSEDGTIKVWDVRSPS----IPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDL 145 Query: 132 NIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEK 191 E H+ T + SLS + +LA T N ++ + + Sbjct: 146 ----GENQCTHQLTPEDDTSLQ---SLSMASDGS-MLAAANTKGNCYVWEMP-NHTDASH 196 Query: 192 CRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKL 251 + V + H ++ + L + S D R+W Sbjct: 197 LKPVTKFRAHSTYITRILLS----SDVKHLATCSADHTARVWS----------------- 235 Query: 252 TLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPD 311 IDD+ ++ + GH W+ + L+ A++D + +W+ Sbjct: 236 -----------IDDDFKLETT----LDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLS 280 Query: 312 ETS 314 Sbjct: 281 TRE 283 Score = 91.9 bits (226), Expect = 1e-18, Method: Composition-based stats. Identities = 59/306 (19%), Positives = 97/306 (31%), Gaps = 43/306 (14%) Query: 117 ISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVN 176 + D TI W + H + L +KK L G NV Sbjct: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDS--------QVNRLEITNDKKLLATAGHQNVR 56 Query: 177 VFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIR 236 ++ + VA EGH V S++F+ + + + S+D I++W +R Sbjct: 57 LYDIRTTNPNP-------VASFEGHRGNVTSVSFQQ----DNRWMVTSSEDGTIKVWDVR 105 Query: 237 INDL--IDDSEEDSKKLTLLSNKQYKFQIDDE-------LRVGINFEALIMGHDDWISSL 287 + ++ + N+ D + L L D + SL Sbjct: 106 SPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSL 165 Query: 288 QWHESRLQLLAATADTSLMVWE-PDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLW 346 L AA + VWE P+ T K + S L Sbjct: 166 SMASDGSMLAAANTKGNCYVWEMPNHTDAS----------HLKPVTKFRAHSTYITRILL 215 Query: 347 FTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLD 406 + + T + R+W+ D+ + L G + V D A+S YL+ S D Sbjct: 216 SSD--VKHLATCSADHTARVWSIDDDFKLETTLD--GHQRWVWDCAFSADSAYLVTASSD 271 Query: 407 QTTRLF 412 RL+ Sbjct: 272 HYVRLW 277 Score = 84.2 bits (206), Expect = 2e-16, Method: Composition-based stats. Identities = 52/340 (15%), Positives = 102/340 (30%), Gaps = 60/340 (17%) Query: 73 FMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS--LISVGCADGTISIWR 130 +VSA DH ++ W+ C +TIQH + L L++ + ++ Sbjct: 4 ILVSAGYDHTIRFWEALTGV---CSRTIQHSDSQVNRLEITNDKKLLATAGH-QNVRLYD 59 Query: 131 QNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIE 190 N + E S+S ++ ++++ + + + + S S Sbjct: 60 IRTTNPNPVASFEGHRGNVT------SVSFQQDNRWMVTS-SEDGTIKVWD-VRSPSIPR 111 Query: 191 KCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRIN----DLIDDSEE 246 + H V + + L S +D IR+W + N L + + Sbjct: 112 NYK-------HNAPVNEVVIHPNQGE----LISCDRDGNIRIWDLGENQCTHQLTPEDDT 160 Query: 247 DSKKLTLLSNKQYKFQIDD------------ELRVGINFEALIMGHDDWISSLQWHESRL 294 + L++ S+ + + H +I+ + Sbjct: 161 SLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVK 220 Query: 295 QLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDF 354 L +AD + VW D+ K +T G W C + + Sbjct: 221 HLATCSADHTARVWSIDDD--------------FKLETTLDGHQRWVWDCAFSADS--AY 264 Query: 355 FLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWS 394 +T R+W I Q G K +A + Sbjct: 265 LVTASSDHYVRLWDLSTREIVRQ---YGGHHKGAVCVALN 301 Score = 78.4 bits (191), Expect = 1e-14, Method: Composition-based stats. Identities = 25/108 (23%), Positives = 48/108 (44%), Gaps = 6/108 (5%) Query: 5 ITPEAIFIGANK-QTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVT 63 + P F + T++ VK + A T +W ++ + TL GH+ V Sbjct: 197 LKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSID--DDFKLETTLDGHQRWVW 254 Query: 64 CVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALS 111 F DS ++V+AS DH+V++W + + ++ + K V ++ Sbjct: 255 DCAFSADSAYLVTASSDHYVRLWDLST---REIVRQYGGHHKGAVCVA 299 Score = 64.9 bits (156), Expect = 1e-10, Method: Composition-based stats. Identities = 45/291 (15%), Positives = 85/291 (29%), Gaps = 50/291 (17%) Query: 218 DYLLCSGSQDRYIRLWRI---RINDLIDDSEEDSKKLTLLSNKQYKFQ-------IDDEL 267 +L S D IR W + I S+ +L + ++K+ + D Sbjct: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIR 61 Query: 268 RVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWE------------------ 309 N A GH ++S+ + + ++ ++ D ++ VW+ Sbjct: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNE 121 Query: 310 ----PDETSGIW------VCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNG 359 P++ I + LGE T + + + T G Sbjct: 122 VVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKG 181 Query: 360 KTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDA 419 W M D + +T I S ++L S D T R ++ Sbjct: 182 NCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTAR-----VWSI 236 Query: 420 SGRKREIATWHEFSRPQIHGYDM-ICVETVTDTRFVSGGDEKILRSFDLPK 469 + T H + C + V+ + +R +DL Sbjct: 237 DDDFKLETTL------DGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLST 281 Score = 61.5 bits (147), Expect = 1e-09, Method: Composition-based stats. Identities = 55/366 (15%), Positives = 115/366 (31%), Gaps = 72/366 (19%) Query: 296 LLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFF 355 L++A D ++ WE VCS + S+ + + + Sbjct: 5 LVSAGYDHTIRFWEALTG----VCSRTIQHSDSQVNRLEITNDKKLLATAGHQN------ 54 Query: 356 LTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPW 415 R++ + G +VT +++ +++ +S D T +++ Sbjct: 55 --------VRLYDIRTTNPNPVA-SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVR 105 Query: 416 IYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKGVAGML 475 + A +E G + C + +R +DL + Sbjct: 106 SPSIPRNYKHNAPVNEVVIHPNQGELISCDR------------DGNIRIWDLGEN----- 148 Query: 476 QKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGN---KETPDITDPLSL 532 Q + D ++ L +++ D + GN E P+ TD L Sbjct: 149 ------QCTHQLTPEDDTSLQSLSMAS-----DGSMLAAANTKGNCYVWEMPNHTDASHL 197 Query: 533 LECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFST 592 V K H IT + +S D K +A+ + R++S Sbjct: 198 ----------------KPVTKFRAHSTYITRILLSSDVKHLATCSADHTA-----RVWSI 236 Query: 593 ENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPH 652 ++ +++ L H + FS D +L++ D LW+ + + + K Sbjct: 237 DDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGH-HKGA 295 Query: 653 TRIIWD 658 + + Sbjct: 296 VCVALN 301 Score = 54.1 bits (128), Expect = 3e-07, Method: Composition-based stats. Identities = 41/239 (17%), Positives = 79/239 (33%), Gaps = 29/239 (12%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 V GH +T + D + + ++ ++ +R S P H+ + Sbjct: 68 VASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSI-------PRNYKHNAPVN 120 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVF 670 + + L+S RD +W+ T +L +++ + +D G++ Sbjct: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASD------GSML 174 Query: 671 VTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIY 730 A+ VW H K VT H + I +L S + Sbjct: 175 AAANTKGNCYVWEMPNH--------TDASHLKPVTKFRAHSTYITRILLSS-----DVKH 221 Query: 731 LYSYTLGKFELITQLNEDI---TPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYSLA 786 L + + + +++D T D R W +L SSD R++ L+ Sbjct: 222 LATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLS 280 >5FVM-C nrPDB Length = 303 Score = 156 bits (394), Expect = 3e-38, Method: Composition-based stats. Identities = 61/281 (21%), Positives = 102/281 (36%), Gaps = 46/281 (16%) Query: 14 ANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDF 73 A+ Q +I KK +A + L+D I NN ++ +GH+ VT + F ++ + Sbjct: 31 ADSQVNRLEITSDKKYLAAAGHLHVRLYD-IRSNNPNPVSSFEGHKGNVTSIAFQQENRW 89 Query: 74 MVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSL--ISVGCADGTISIWRQ 131 MVS+SED +K+W S +Q ++ + ++ P+ + DG I IW Sbjct: 90 MVSSSEDGTIKVWDVRSPS----VQRNYKHNAPVNEVAIHPNQGELISCDQDGNIRIWDL 145 Query: 132 NIQNDEFGLAHEFTI------------------KKGFFY----PLCLSLSKVEE------ 163 L E KG Y P S +E Sbjct: 146 GENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKS 205 Query: 164 -----KKYLLAIGGTNVNVFIASFILSDSGIE-KCRVVAELEGHEDWVKSLAFRHQETPG 217 + LL+ N+ A IE ++ L+GH+ WV AF Sbjct: 206 HTKYITRVLLSADVKNLATCSADHTARVWNIEDNYQLETTLDGHQRWVWDCAFS----AD 261 Query: 218 DYLLCSGSQDRYIRLWRIRINDLIDDSEEDSK-KLTLLSNK 257 L + D Y+RLW + ++++ K + + N Sbjct: 262 SAYLVTACSDHYVRLWDLSTSEIVRQYGGHHKGAVCVALND 302 Score = 96.1 bits (237), Expect = 5e-20, Method: Composition-based stats. Identities = 54/301 (17%), Positives = 107/301 (35%), Gaps = 33/301 (10%) Query: 117 ISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVN 176 ++ D TI W + H + L +KKYL A G +++ Sbjct: 5 LASAGYDHTIRFWEALTGVCSRTIQHADS--------QVNRLEITSDKKYLAAAG--HLH 54 Query: 177 VFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIR 236 V + ++ V+ EGH+ V S+AF+ + + + S S+D I++W +R Sbjct: 55 VRLYDIRSNNPNP-----VSSFEGHKGNVTSIAFQQE----NRWMVSSSEDGTIKVWDVR 105 Query: 237 IN--DLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRL 294 ++ + N+ D + + I ++ ++ E Sbjct: 106 SPSVQRNYKHNAPVNEVAIHPNQGELISCDQDGNIRIWDLG-----ENQCTNQLTPEDNT 160 Query: 295 QL--LAATADTSLMVWEPDETSG-IWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHER 351 L L+ +D S++V ++ + +W + + + + L + Sbjct: 161 PLQSLSVASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVK 220 Query: 352 MDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRL 411 T + R+W +DN + L G + V D A+S YL+ D RL Sbjct: 221 N--LATCSADHTARVWNIEDNYQLETTLD--GHQRWVWDCAFSADSAYLVTACSDHYVRL 276 Query: 412 F 412 + Sbjct: 277 W 277 Score = 78.8 bits (192), Expect = 9e-15, Method: Composition-based stats. Identities = 52/338 (15%), Positives = 106/338 (31%), Gaps = 56/338 (16%) Query: 73 FMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQN 132 + SA DH ++ W+ + IQ + S L + G + ++ + Sbjct: 4 ILASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGHL--HVRLY--D 59 Query: 133 IQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKC 192 I+++ F KG S++ +E +++++ + + + + S S Sbjct: 60 IRSNNPNPVSSFEGHKGNV----TSIAFQQENRWMVSS-SEDGTIKVWD-VRSPSVQRNY 113 Query: 193 RVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIR----INDLIDDSEEDS 248 + H V +A + L S QD IR+W + N L + Sbjct: 114 K-------HNAPVNEVAIHPNQGE----LISCDQDGNIRIWDLGENQCTNQLTPEDNTPL 162 Query: 249 KKLTLLSNKQYKFQIDD------------ELRVGINFEALIMGHDDWISSLQWHESRLQL 296 + L++ S+ ++ + H +I+ + L Sbjct: 163 QSLSVASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNL 222 Query: 297 LAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFL 356 +AD + VW E + + +T G W C + + + Sbjct: 223 ATCSADHTARVWNI--------------EDNYQLETTLDGHQRWVWDCAFSADS--AYLV 266 Query: 357 TNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWS 394 T R+W + I Q G K +A + Sbjct: 267 TACSDHYVRLWDLSTSEIVRQ---YGGHHKGAVCVALN 301 Score = 68.8 bits (166), Expect = 8e-12, Method: Composition-based stats. Identities = 46/291 (15%), Positives = 90/291 (30%), Gaps = 50/291 (17%) Query: 218 DYLLCSGSQDRYIRLWRI---RINDLIDDSEEDSKKLTLLSNKQYKFQ-------IDDEL 267 +L S D IR W + I ++ +L + S+K+Y + D Sbjct: 2 SVILASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGHLHVRLYDIR 61 Query: 268 RVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWE------------------ 309 N + GH ++S+ + + +++++ D ++ VW+ Sbjct: 62 SNNPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYKHNAPVNE 121 Query: 310 ----PDETSGIW------VCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNG 359 P++ I + LGE T ++ + + G Sbjct: 122 VAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNKG 181 Query: 360 KTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDA 419 WRM D + TK +T + S + L S D T R +++ Sbjct: 182 NCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTAR-----VWNI 236 Query: 420 SGRKREIATWHEFSRPQIHGYDM-ICVETVTDTRFVSGGDEKILRSFDLPK 469 + T H + C + V+ + +R +DL Sbjct: 237 EDNYQLETTL------DGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLST 281 Score = 64.5 bits (155), Expect = 2e-10, Method: Composition-based stats. Identities = 61/369 (16%), Positives = 120/369 (32%), Gaps = 78/369 (21%) Query: 296 LLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFF 355 L +A D ++ WE VCS + S+ S + + H Sbjct: 5 LASAGYDHTIRFWEALTG----VCSRTIQHADSQVNRLEITSDKKYLAAAGHLH------ 54 Query: 356 LTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPW 415 R++ + N G +VT IA+ +++++S D T +++ Sbjct: 55 --------VRLYDIRSNNPNPVS-SFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVR 105 Query: 416 IYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKGVAGML 475 + A +E + G + C + + +R +DL + Sbjct: 106 SPSVQRNYKHNAPVNEVAIHPNQGELISCDQ------------DGNIRIWDLGEN----- 148 Query: 476 QKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNK------ETPDITDP 529 + +++ P+ LS A++ G NK P TD Sbjct: 149 --------QCTNQLTPEDNTPLQSLSV------ASDGSMLVAGNNKGNCYVWRMPHHTDA 194 Query: 530 LSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRI 589 +L V K H IT + +S D K +A+ + R+ Sbjct: 195 STL----------------EPVTKFKSHTKYITRVLLSADVKNLATCSADHTA-----RV 233 Query: 590 FSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNE 649 ++ E+ +++ L H + FS D +L++ C D LW+ + + + Sbjct: 234 WNIEDNYQLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLSTSEIVRQYGGH-H 292 Query: 650 KPHTRIIWD 658 K + + Sbjct: 293 KGAVCVALN 301 Score = 59.1 bits (141), Expect = 7e-09, Method: Composition-based stats. Identities = 35/158 (22%), Positives = 58/158 (36%), Gaps = 13/158 (8%) Query: 549 PEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLT 608 P V++ Y H + + I P+Q + S + N IRI+ P + Sbjct: 107 PSVQRNYKHNAPVNEVAIHPNQGELISCDQDGN-----IRIWDLGENQCTNQLTPEDNTP 161 Query: 609 ITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELR-FKNEKPHTRIIWDADWAPLEFG 667 + L + DG L++ +W + L K HT+ I + Sbjct: 162 LQSLSVASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSA--DV 219 Query: 668 NVFVTASRDKTVKVWRHQKEPADDYVLEASI-KHTKAV 704 T S D T +VW + D+Y LE ++ H + V Sbjct: 220 KNLATCSADHTARVWNIE----DNYQLETTLDGHQRWV 253 Score = 49.5 bits (116), Expect = 6e-06, Method: Composition-based stats. Identities = 58/360 (16%), Positives = 115/360 (31%), Gaps = 65/360 (18%) Query: 355 FLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAP 414 + G + R W + I A V + + +YL A Sbjct: 5 LASAGYDHTIRFWEALTGVCSR---TIQHADSQVNRLEITSDKKYLAAAGH------LHV 55 Query: 415 WIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTR-FVSGGDEKILRSFDLPKGVAG 473 +YD + S + H ++ + + R VS ++ ++ +D+ Sbjct: 56 RLYDIRSNNP-----NPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRS---- 106 Query: 474 MLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANE--DDEEEEGGNKETPDITDPLS 531 V ++ + + + A P G +D D E + N+ TP+ PL Sbjct: 107 ---PSVQRNYKHNAPVNEVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQ 163 Query: 532 LLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFS 591 L ++ D ++ + N + + Sbjct: 164 -------------------------------SLSVASDGSMLVAGNNKGNCYVWRMPHHT 192 Query: 592 TENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKP 651 + LE H+ ITR+ S D K L + D +W ++ ++L + Sbjct: 193 DASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNI---EDNYQLETTLD-G 248 Query: 652 HTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHD 711 H R +WD ++ VTA D V++W + ++ H K ++++D Sbjct: 249 HQRWVWDCAFSADSA--YLVTACSDHYVRLWDL----STSEIVRQYGGHHKGAVCVALND 302 >3DM0-A nrPDB Length = 694 Score = 151 bits (380), Expect = 1e-36, Method: Composition-based stats. Identities = 57/318 (17%), Positives = 111/318 (34%), Gaps = 48/318 (15%) Query: 23 IHKVKKIVAFGAGKTIALWDPIEPNNKGVYA--TLKGHEAEVTCVRFVPDSDFMVSASED 80 I IV+ K+I LW + + A L GH V V D F +S S D Sbjct: 392 IDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVLSSDGQFALSGSWD 451 Query: 81 HHVKIWKFTDYSHLQCIQTIQHYSKTIVALSA--LPSLISVGCADGTISIWRQNIQNDEF 138 +++W + ++K +++++ I D TI +W + ++ Sbjct: 452 GELRLWDLAAGVST---RRFVGHTKDVLSVAFSLDNRQIVSASRDRTIKLWNT-LGECKY 507 Query: 139 GLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAEL 198 ++ + + C+ S + +++ + + C++ + L Sbjct: 508 TISEGGEGHRD--WVSCVRFSPNTLQPTIVSA--------SWDKTVKVWNLSNCKLRSTL 557 Query: 199 EGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDS--KKLTLLSN 256 GH +V ++A P L SG +D + LW + + E +S L N Sbjct: 558 AGHTGYVSTVAVS----PDGSLCASGGKDGVVLLWDLAEGKKLYSLEANSVIHALCFSPN 613 Query: 257 K-------QYKFQIDD--------ELRVGINFEALIMGHDD---------WISSLQWHES 292 + ++ +I D +L+V + EA + + +SL W Sbjct: 614 RYWLCAATEHGIKIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKVIYCTSLNWSAD 673 Query: 293 RLQLLAATADTSLMVWEP 310 L + D + VW Sbjct: 674 GSTLFSGYTDGVIRVWGI 691 Score = 123 bits (308), Expect = 3e-28, Method: Composition-based stats. Identities = 61/373 (16%), Positives = 122/373 (32%), Gaps = 64/373 (17%) Query: 54 TLKGHEAEVTCVRFVPDS-DFMVSASEDHHVKIWKFT--DYSHLQCIQTIQHYSKTI--V 108 T++ H VT + D+ D +VSAS D + +WK T D ++ + + +S + V Sbjct: 377 TMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDV 436 Query: 109 ALSALPSLISVGCADGTISIWRQNIQNDEF-GLAHEFTIKKGFFYPLCLSLSKVEEKKYL 167 LS+ G DG + +W + H + LS++ + + + Sbjct: 437 VLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDV---------LSVAFSLDNRQI 487 Query: 168 LAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQD 227 ++ + + + + G K + EGH DWV + F + S S D Sbjct: 488 VS-ASRDRTIKLW----NTLGECKYTISEGGEGHRDWVSCVRFSPNTLQ--PTIVSASWD 540 Query: 228 RYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSL 287 + +++W + L + + GH ++S++ Sbjct: 541 KTVKVWNLSNCKL---------------------------------RSTLAGHTGYVSTV 567 Query: 288 QWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWF 347 + D +++W+ E ++ + + +W C Sbjct: 568 AVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEANSVIHALCFSP------NRYWLCAAT 621 Query: 348 THERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDV---TDIAWSPSGEYLLATS 404 H + L + K G + + V T + WS G L + Sbjct: 622 EHGIKIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKVIYCTSLNWSADGSTLFSGY 681 Query: 405 LDQTTRLFAPWIY 417 D R++ Y Sbjct: 682 TDGVIRVWGIGRY 694 Score = 102 bits (254), Expect = 6e-22, Method: Composition-based stats. Identities = 34/204 (16%), Positives = 74/204 (36%), Gaps = 30/204 (14%) Query: 270 GINFEALIMGHDDWISSLQWHESRL-QLLAATADTSLMVWEPDETSGIWVCSLRLGEMSS 328 G+ + + H D ++++ +++A+ D S+++W+ + + + + Sbjct: 371 GLVLKGTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDK----AYGVAQRRL 426 Query: 329 KGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDV 388 G S L + L+ G R+W + + G TKDV Sbjct: 427 TGHSHFVED-----VVLSSDGQFA---LSGSWDGELRLWDLAAGVSTRR---FVGHTKDV 475 Query: 389 TDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQ-IHGYDMICVE- 446 +A+S +++ S D+T +L ++ G + S H + CV Sbjct: 476 LSVAFSLDNRQIVSASRDRTIKL-----WNTLGE-----CKYTISEGGEGHRDWVSCVRF 525 Query: 447 --TVTDTRFVSGGDEKILRSFDLP 468 VS +K ++ ++L Sbjct: 526 SPNTLQPTIVSASWDKTVKVWNLS 549 Score = 88.0 bits (216), Expect = 1e-17, Method: Composition-based stats. Identities = 48/250 (19%), Positives = 89/250 (35%), Gaps = 33/250 (13%) Query: 554 LYGHGFEITCLDISPDQK-LIASACRSNNVQNAVIRIFSTENWLEIKPA---LPFHSLTI 609 + H +T + D +I SA R ++I T++ A L HS + Sbjct: 378 MRAHTDMVTAIATPIDNADIIVSASRD----KSIILWKLTKDDKAYGVAQRRLTGHSHFV 433 Query: 610 TRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNV 669 + S DG+F LS D + LW+ + RF + A Sbjct: 434 EDVVLSSDGQFALSGSWDGELRLWD--LAAGVSTRRFVGHTKDVLSV-----AFSLDNRQ 486 Query: 670 FVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISV------- 722 V+ASRD+T+K+W E + E H V+ + + ++ I+ + Sbjct: 487 IVSASRDRTIKLWNTLGEC-KYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKV 545 Query: 723 -GLENGEIYLYSYTLGKFELITQLNED----ITPADKITRLRWSHLKRNGKLFLGVGSSD 777 L N ++ + ++ D + L W + KL+ S + Sbjct: 546 WNLSNCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGK-KLY----SLE 600 Query: 778 LSTRIYSLAY 787 ++ I++L + Sbjct: 601 ANSVIHALCF 610 Score = 79.2 bits (193), Expect = 7e-15, Method: Composition-based stats. Identities = 67/381 (17%), Positives = 132/381 (34%), Gaps = 81/381 (21%) Query: 380 GISGATKDVTDIAWSPSG-EYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIH 438 + T VT IA + +++ S D++ L+ K + A R H Sbjct: 377 TMRAHTDMVTAIATPIDNADIIVSASRDKSIILW-------KLTKDDKAYGVAQRRLTGH 429 Query: 439 GYDMICVETVTDTRF-VSGGDEKILRSFDLPKGVAGMLQKFVG-------IQFE-EKSEM 489 + + V +D +F +SG + LR +DL GV+ ++FVG + F + ++ Sbjct: 430 SHFVEDVVLSSDGQFALSGSWDGELRLWDLAAGVS--TRRFVGHTKDVLSVAFSLDNRQI 487 Query: 490 PDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWP 549 ++ + L N GE EGG Sbjct: 488 VSASRDRTIKLWNTLGECKYTI----SEGG------------------------------ 513 Query: 550 EVEKLYGHGFEITCLDISPD--QKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSL 607 GH ++C+ SP+ Q I SA +++++ N +++ L H+ Sbjct: 514 -----EGHRDWVSCVRFSPNTLQPTIVSASWDKT-----VKVWNLSN-CKLRSTLAGHTG 562 Query: 608 TITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFG 667 ++ + S DG S +D LW+ + L +I ++P + Sbjct: 563 YVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEAN------SVIHALCFSPNRY- 615 Query: 668 NVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLE-- 725 A+ +K+W + + + + +A A + + + K++ L Sbjct: 616 -WLCAATEHG-IKIWDLESKSIVEDLKVDL--KAEAEKADNSGPAATKRKVIYCTSLNWS 671 Query: 726 -NGEIYLYSYTLGKFELITQL 745 +G YT G + + Sbjct: 672 ADGSTLFSGYTDG-VIRVWGI 691 >5WLC-LO nrPDB Length = 923 Score = 149 bits (375), Expect = 5e-36, Method: Composition-based stats. Identities = 52/226 (23%), Positives = 101/226 (44%), Gaps = 25/226 (11%) Query: 12 IGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDS 71 +G N VS +++ + +AFG+ K L E ++ +GH + + PD Sbjct: 300 MGQNPVNTVS-VNQTGEWLAFGSSKLGQLL-VYEWQSESYILKQQGHFDSTNSLAYSPDG 357 Query: 72 DFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVAL--SALPSLISVGCADGTISIW 129 +V+ASED +K+W T C+ T + ++ ++ A+ + ++ DGT+ W Sbjct: 358 SRVVTASEDGKIKVWDITSGF---CLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAW 414 Query: 130 RQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGI 189 I+ F FT + + CL++ E ++ +++V+ + Sbjct: 415 DL-IRYRNF---RTFTGTERIQFN-CLAVDPSGEVVCAGSLDNFDIHVWS---------V 460 Query: 190 EKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI 235 + +++ L GHE V L+F + + +L S S D+ IR+W I Sbjct: 461 QTGQLLDALSGHEGPVSCLSFSQENS----VLASASWDKTIRIWSI 502 Score = 135 bits (338), Expect = 1e-31, Method: Composition-based stats. Identities = 102/616 (16%), Positives = 199/616 (32%), Gaps = 122/616 (19%) Query: 17 QTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVS 76 T ++ + I+ + +W T GH V F D + + + Sbjct: 149 ITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYT 208 Query: 77 ASEDHHVKIWKFT--------------------DYSHLQ----CIQTIQHYSKTIVALSA 112 S+D V +W+FT D S + ++ Sbjct: 209 VSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTF 268 Query: 113 LPS--LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAI 170 P+ L++VG G ++ +F L + ++ + +S+++ E LA Sbjct: 269 HPATRLLAVGFTSGEFRLYDL----PDFTLIQQLSMGQNP--VNTVSVNQTGE---WLAF 319 Query: 171 GGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYI 230 G + + ++ + E + +GH D SLA+ P + + S+D I Sbjct: 320 GSS----KLGQLLVYEWQSESYILKQ--QGHFDSTNSLAYS----PDGSRVVTASEDGKI 369 Query: 231 RLWRIR---INDLIDDSEEDSKKLTLLSNKQYKF--QIDDELRV-----GINFEALIMGH 280 ++W I ++ + Q F +D +R NF Sbjct: 370 KVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTE 429 Query: 281 DDWISSLQWHESRLQLLAATADT-SLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSG 339 + L S + A + D + VW + A Sbjct: 430 RIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLL----------------DALSGHE 473 Query: 340 GFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEY 399 G SCL F+ E + + R+W+ Q++ DV ++ P G+ Sbjct: 474 GPVSCLSFSQENSV-LASASWDKTIRIWSIFGR---SQQVEPIEVYSDVLALSMRPDGKE 529 Query: 400 LLATSLDQTTRLF----APWIYDASGRKREIATWHEFSRPQIHG-----YDMICVETVTD 450 + ++L +F A + + RK I+ R + + Sbjct: 530 VAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDG 589 Query: 451 TRFVSGGDEKILRSFDLPKGVAGMLQKFV---------GIQFEEKSEMPDSATVPVLGLS 501 V+GG+ + +D+P V +L++F+ ++F +M ++ ++ ++ Sbjct: 590 MAIVAGGNNNSICLYDVPNEV--LLKRFIVSRNMALNGTLEFLNSKKMTEAGSLDLI--- 644 Query: 502 NKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEI 561 DDA E+ + E + D + P S L + PEV + Sbjct: 645 -----DDAGENSDLE-----DRIDNSLPGS-----QRGGDLSTRKMRPEVR--------V 681 Query: 562 TCLDISPDQKLIASAC 577 T + SP A+A Sbjct: 682 TSVQFSPTANAFAAAS 697 Score = 115 bits (287), Expect = 9e-26, Method: Composition-based stats. Identities = 95/675 (14%), Positives = 200/675 (29%), Gaps = 123/675 (18%) Query: 17 QTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVS 76 Q ++ K++++ + ++++D I + H + + ++S Sbjct: 17 QGNITFSDDGKQLLSPVGNR-VSVFDLINNKSFTFEYE---HRKNIAAIDLNKQGTLLIS 72 Query: 77 ASEDHHVKIWKFTDYSHLQCIQTIQHY-----SKTIVALSALPSLISVGCADGTISIWRQ 131 ED + F + + H+ + V S L ++ + IW+ Sbjct: 73 IDEDGRAILVNF-------KARNVLHHFNFKEKCSAVKFSPDGRLFALASG-RFLQIWKT 124 Query: 132 -NIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIE 190 ++ D + SL+ ++ +++L +++ I S + + Sbjct: 125 PDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTT-SKDLSAKIWSVDSEEKNLA 183 Query: 191 KCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKK 250 GH D+V F H + + S+D + +W DD E Sbjct: 184 A----TTFNGHRDYVMGAFFSH----DQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDD 235 Query: 251 LTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEP 310 I + + + + +H + L +++ Sbjct: 236 DK-QEEVDISKYSWR-----ITKKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDL 289 Query: 311 DETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRM--WA 368 + + I S+ + + + +G + + + K G + W Sbjct: 290 PDFTLIQQLSMG----QNPVNTVSVNQTGEWLA------------FGSSKLGQLLVYEWQ 333 Query: 369 TKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIAT 428 ++ I+ Q G +A+SP G ++ S D + ++D + Sbjct: 334 SESYILKQQ-----GHFDSTNSLAYSPDGSRVVTASEDGKIK-----VWDIT----SGFC 379 Query: 429 WHEFSRPQIHGYDMICVE-TVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVG---IQFE 484 F H + V+ S + +R++DL + + F G IQF Sbjct: 380 LATFEE---HTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIR--YRNFRTFTGTERIQFN 434 Query: 485 EKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDI----TDPLSLLECPPMED 540 + P V L N DI LL+ Sbjct: 435 CLAVDPSGEVVCAGSLDNF---------------------DIHVWSVQTGQLLDA----- 468 Query: 541 QLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKP 600 L GH ++CL S + ++ASA IRI+S + Sbjct: 469 -------------LSGHEGPVSCLSFSQENSVLASASWDKT-----IRIWSIFGRSQQVE 510 Query: 601 ALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDAD 660 + +S + L DGK + + +++ + + + R D Sbjct: 511 PIEVYSD-VLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRF 569 Query: 661 WAPLEFGNVFVTASR 675 A + F T Sbjct: 570 TAKNSERSKFFTTIH 584 Score = 88.0 bits (216), Expect = 2e-17, Method: Composition-based stats. Identities = 104/555 (18%), Positives = 173/555 (31%), Gaps = 108/555 (19%) Query: 243 DSEEDSKKLTLLSNKQYKFQIDDELRV-GINFEALIMGH----DDWISSLQWHESRLQLL 297 + ++ + L ID++ R +NF+A + H + S++++ Sbjct: 53 EHRKNIAAIDLNKQGTLLISIDEDGRAILVNFKARNVLHHFNFKEKCSAVKFSPDGRLFA 112 Query: 298 AATADTSLMVWE-PDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFL 356 A+ L +W+ PD G S W R F L Sbjct: 113 LASGRF-LQIWKTPDVNKDRQFAPFVR-------HRVHAGHFQDITSLTWSQDSR--FIL 162 Query: 357 TNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFA--- 413 T K S ++W+ +G V +S E + S D ++ Sbjct: 163 TTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTK 222 Query: 414 ---------------PWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGD 458 D S I H F Q + CV TR ++ G Sbjct: 223 RPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAK---VKCVTFHPATRLLAVGF 279 Query: 459 EK-ILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEE 517 R +DLP F IQ + P + TV V N+ GE A Sbjct: 280 TSGEFRLYDLP--------DFTLIQQLSMGQNPVN-TVSV----NQTGEWLAF------- 319 Query: 518 GGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASAC 577 G +K L + E Q + ++L K GH L SPD + +A Sbjct: 320 GSSK----------LGQLLVYEWQSESYIL-----KQQGHFDSTNSLAYSPDGSRVVTAS 364 Query: 578 RSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNM 637 I+++ + + H+ ++T ++F+K G+ + S D W+ Sbjct: 365 EDGK-----IKVWDITSGFCL-ATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIR 418 Query: 638 EDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDK-TVKVWRHQKEPADDYVLEA 696 N T I A G V S D + VW Q +L+A Sbjct: 419 YRNFRTFTG------TERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQ----TGQLLDA 468 Query: 697 SIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKFELITQL---NEDITPAD 753 H V+ +S EN L S + K I + ++ + P + Sbjct: 469 LSGHEGPVSCLSF-------------SQENS--VLASASWDKTIRIWSIFGRSQQVEPIE 513 Query: 754 KITRLRWSHLKRNGK 768 + + ++ +GK Sbjct: 514 VYSDVLALSMRPDGK 528 Score = 81.9 bits (200), Expect = 1e-15, Method: Composition-based stats. Identities = 58/366 (15%), Positives = 109/366 (29%), Gaps = 90/366 (24%) Query: 15 NKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFM 74 + ++ ++V I +WD + AT + H + VT V+F M Sbjct: 346 DSTNSLAYSPDGSRVVTASEDGKIKVWDI---TSGFCLATFEEHTSSVTAVQFAKRGQVM 402 Query: 75 VSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADG-TISIWRQNI 133 S+S D V+ W Y + + + +A+ ++ G D I +W Sbjct: 403 FSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQT 462 Query: 134 QNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCR 193 L + +G CLS S+ +LA + + I S +E Sbjct: 463 GQ----LLDALSGHEGP--VSCLSFSQENS---VLASASWDKTIRIWSIFGRSQQVEPIE 513 Query: 194 V-----------------VAELEGHED-----------------WVKSLAFRHQETP--- 216 V V+ L+G + S F Sbjct: 514 VYSDVLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKN 573 Query: 217 --------------GDYLLCSGSQDRYIRLWRIRINDLIDDSEE-------------DSK 249 + +G + I L+ + L+ +SK Sbjct: 574 SERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRFIVSRNMALNGTLEFLNSK 633 Query: 250 KLTLLS----------NKQYKFQIDDEL---RVGINFEALIMGHDDWISSLQWHESRLQL 296 K+T N + +ID+ L + G + M + ++S+Q+ + Sbjct: 634 KMTEAGSLDLIDDAGENSDLEDRIDNSLPGSQRGGDLSTRKMRPEVRVTSVQFSPTANAF 693 Query: 297 LAATAD 302 AA+ + Sbjct: 694 AAASTE 699 Score = 59.5 bits (142), Expect = 5e-09, Method: Composition-based stats. Identities = 38/237 (16%), Positives = 89/237 (37%), Gaps = 31/237 (13%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 +++L + + ++ + +A + + ++ + +E+++ + H + Sbjct: 295 IQQLSMGQNPVNTVSVNQTGEWLAFGS--SKLGQLLVYEWQSESYILKQ---QGHFDSTN 349 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVF 670 L +S DG +++ D K +W+ + HT + +A G V Sbjct: 350 SLAYSPDGSRVVTASEDGKIKVWDITSGFCLATF-----EEHTSSVTAVQFAKR--GQVM 402 Query: 671 VTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIRE--KILISVGLENGE 728 ++S D TV+ W Y + T+ I + + +++ + L+N + Sbjct: 403 FSSSLDGTVRAWDL-----IRYRNFRTFTGTE---RIQFNCLAVDPSGEVVCAGSLDNFD 454 Query: 729 IYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYSL 785 I+++S G+ D + S + N L S D + RI+S+ Sbjct: 455 IHVWSVQTGQLL-------DALSGHEGPVSCLSFSQENS--VLASASWDKTIRIWSI 502 >6HQA-B nrPDB Length = 722 Score = 148 bits (373), Expect = 9e-36, Method: Composition-based stats. Identities = 60/322 (18%), Positives = 96/322 (29%), Gaps = 78/322 (24%) Query: 10 IFIGANKQTQVSDIHKVKKIVAFGA-GKTIALW-------------DPIEPNNKGVYA-- 53 F N + +VA G I LW DP N A Sbjct: 385 TFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGVAVK 444 Query: 54 ---TLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVAL 110 L GH V V F PD+ +++S SED V++W C+ + + +S ++ + Sbjct: 445 GSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDT---YTCLVSYKGHSSSVWDV 501 Query: 111 SALP--SLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLL 168 P + D T +W H + ++ + + + L Sbjct: 502 KFSPMGHYFATASHDQTARLW---------SCDHIYPLRIFAGHLNDVDCVEFHPNSTYL 552 Query: 169 AIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDR 228 G ++ + I + V GH + LA P L S +D Sbjct: 553 FTGSSDKTARMW-------DIARGECVRVFMGHSGAINCLAVS----PDGRWLASAGEDS 601 Query: 229 YIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGH-DDWISSL 287 + LW I I + GH I SL Sbjct: 602 VVCLWDISTGRRI---------------------------------KAMRGHGRSSIYSL 628 Query: 288 QWHESRLQLLAATADTSLMVWE 309 + L++ AD S+ VW+ Sbjct: 629 AFSREGTVLVSTGADNSVRVWD 650 Score = 110 bits (274), Expect = 3e-24, Method: Composition-based stats. Identities = 55/301 (18%), Positives = 98/301 (32%), Gaps = 54/301 (17%) Query: 194 VVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTL 253 + + + L F ++ SG QD +I+LW I + S +L Sbjct: 382 CMYTFHNTNNDLTCLKFND----DSTMVASGFQDSFIKLWSI----------DGSPLRSL 427 Query: 254 LSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDET 313 L N Y Q +D V + ++GH + + + L++ + D ++ +W D Sbjct: 428 LKNDPYNQQNNDG--VAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTY 485 Query: 314 SG--------IWVCSLRLGEMSSKGASTATGSSGGFWSCLWFT----------------- 348 + V ++ M A+ + + WSC Sbjct: 486 TCLVSYKGHSSSVWDVKFSPMGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEF 545 Query: 349 HERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQT 408 H + T + RMW G + + +A SP G +L + D Sbjct: 546 HPNSTYLFTGSSDKTARMWDIARGECVRV---FMGHSGAINCLAVSPDGRWLASAGEDSV 602 Query: 409 TRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLP 468 ++D S R I R I+ + T VS G + +R +D+ Sbjct: 603 V-----CLWDIS-TGRRIKAMRGHGRSSIY----SLAFSREGTVLVSTGADNSVRVWDVK 652 Query: 469 K 469 K Sbjct: 653 K 653 Score = 102 bits (254), Expect = 5e-22, Method: Composition-based stats. Identities = 27/129 (20%), Positives = 48/129 (37%), Gaps = 4/129 (3%) Query: 5 ITPEAIFIGANKQTQVSDIH-KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVT 63 I P IF G + H + + KT +WD GH + Sbjct: 527 IYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTARMWDIARGE---CVRVFMGHSGAIN 583 Query: 64 CVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCAD 123 C+ PD ++ SA ED V +W + ++ ++ S +A S +++ AD Sbjct: 584 CLAVSPDGRWLASAGEDSVVCLWDISTGRRIKAMRGHGRSSIYSLAFSREGTVLVSTGAD 643 Query: 124 GTISIWRQN 132 ++ +W Sbjct: 644 NSVRVWDVK 652 Score = 88.8 bits (218), Expect = 9e-18, Method: Composition-based stats. Identities = 56/298 (18%), Positives = 106/298 (35%), Gaps = 48/298 (16%) Query: 521 KETPDITDPLSLLE---CPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASAC 577 K D+ + +++++ Q L + + ++TCL + D ++AS Sbjct: 350 KSAQDLRNDIAMIQDSRAKIKLSAAQASLPSVCMYTFHNTNNDLTCLKFNDDSTMVASGF 409 Query: 578 RSNNVQNAVIRIFSTENWLEIKP---------------ALPFHSLTITRLKFSKDGKFLL 622 + + ++ I + L+ P L HS + + FS D ++L+ Sbjct: 410 QDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGVAVKGSRRLVGHSGAVYGVDFSPDNRYLI 469 Query: 623 SVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVW 682 S D+ LW + + + K H+ +WD ++P+ G+ F TAS D+T ++W Sbjct: 470 SCSEDKTVRLWSLDT----YTC-LVSYKGHSSSVWDVKFSPM--GHYFATASHDQTARLW 522 Query: 683 RHQKEPADDYVLEASIKHTKAVTAISIHD--------SMIREKILISVGLENGEIYLYSY 734 Y L H V + H S + + + + Sbjct: 523 S----CDHIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTARMWDIARGECVRVFMGH 578 Query: 735 TLGKFELITQLNED----ITPADKITRLRWSHLK-RNGKLFLGVGSSDLSTRIYSLAY 787 + G + ++ D + + W R K G G S IYSLA+ Sbjct: 579 S-GAINCL-AVSPDGRWLASAGEDSVVCLWDISTGRRIKAMRGHGRSS----IYSLAF 630 Score = 84.2 bits (206), Expect = 2e-16, Method: Composition-based stats. Identities = 27/137 (19%), Positives = 49/137 (35%), Gaps = 12/137 (8%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 + GH ++ C++ P+ + + R++ ++ + HS I Sbjct: 530 LRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTA-----RMWDIARGECVRVFM-GHSGAIN 583 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVF 670 L S DG++L S D LW+ + +R A G V Sbjct: 584 CLAVSPDGRWLASAGEDSVVCLWDISTGRRIKAMRGHGRSSIYS------LAFSREGTVL 637 Query: 671 VTASRDKTVKVWRHQKE 687 V+ D +V+VW +K Sbjct: 638 VSTGADNSVRVWDVKKN 654 Score = 79.9 bits (195), Expect = 3e-15, Method: Composition-based stats. Identities = 58/337 (17%), Positives = 114/337 (33%), Gaps = 78/337 (23%) Query: 281 DDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMS------SKGASTA 334 ++ ++ L++++ + + D+ + +W D + + KG+ Sbjct: 390 NNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGVAVKGSRRL 449 Query: 335 TGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWS 394 G SG + + R + ++ + + R+W+ + G + V D+ +S Sbjct: 450 VGHSGAVYGVDFSPDNR--YLISCSEDKTVRLWSLDTYTCL---VSYKGHSSSVWDVKFS 504 Query: 395 PSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVE-TVTDTRF 453 P G Y S DQT RL++ + H D+ CVE T Sbjct: 505 PMGHYFATASHDQTARLWS------------CDHIYPLRIFAGHLNDVDCVEFHPNSTYL 552 Query: 454 VSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLS------NKAGED 507 +G +K R +D+ +G ++ F+G S + L +S AGED Sbjct: 553 FTGSSDKTARMWDIARGEC--VRVFMG----------HSGAINCLAVSPDGRWLASAGED 600 Query: 508 DANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHG-FEITCLDI 566 + C +R ++ + GHG I L Sbjct: 601 S------------------------VVCLWDISTGRR------IKAMRGHGRSSIYSLAF 630 Query: 567 SPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALP 603 S + ++ S N+ +R++ + A P Sbjct: 631 SREGTVLVSTGADNS-----VRVWDVKKNTNSPSAQP 662 >5I2T-A nrPDB Length = 742 Score = 148 bits (372), Expect = 1e-35, Method: Composition-based stats. Identities = 52/226 (23%), Positives = 101/226 (44%), Gaps = 25/226 (11%) Query: 12 IGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDS 71 +G N VS +++ + +AFG+ K L E ++ +GH + + PD Sbjct: 325 MGQNPVNTVS-VNQTGEWLAFGSSKLGQLL-VYEWQSESYILKQQGHFDSTNSLAYSPDG 382 Query: 72 DFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVAL--SALPSLISVGCADGTISIW 129 +V+ASED +K+W T C+ T + ++ ++ A+ + ++ DGT+ W Sbjct: 383 SRVVTASEDGKIKVWDITSGF---CLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAW 439 Query: 130 RQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGI 189 I+ F FT + + CL++ E ++ +++V+ + Sbjct: 440 DL-IRYRNF---RTFTGTERIQFN-CLAVDPSGEVVCAGSLDNFDIHVWS---------V 485 Query: 190 EKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI 235 + +++ L GHE V L+F + + +L S S D+ IR+W I Sbjct: 486 QTGQLLDALSGHEGPVSCLSFSQENS----VLASASWDKTIRIWSI 527 Score = 133 bits (334), Expect = 3e-31, Method: Composition-based stats. Identities = 102/616 (16%), Positives = 199/616 (32%), Gaps = 122/616 (19%) Query: 17 QTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVS 76 T ++ + I+ + +W T GH V F D + + + Sbjct: 174 ITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYT 233 Query: 77 ASEDHHVKIWKFT--------------------DYSHLQ----CIQTIQHYSKTIVALSA 112 S+D V +W+FT D S + ++ Sbjct: 234 VSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTF 293 Query: 113 LPS--LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAI 170 P+ L++VG G ++ +F L + ++ + +S+++ E LA Sbjct: 294 HPATRLLAVGFTSGEFRLYDL----PDFTLIQQLSMGQNP--VNTVSVNQTGE---WLAF 344 Query: 171 GGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYI 230 G + + ++ + E + +GH D SLA+ P + + S+D I Sbjct: 345 GSS----KLGQLLVYEWQSESYILKQ--QGHFDSTNSLAYS----PDGSRVVTASEDGKI 394 Query: 231 RLWRIR---INDLIDDSEEDSKKLTLLSNKQYKF--QIDDELRV-----GINFEALIMGH 280 ++W I ++ + Q F +D +R NF Sbjct: 395 KVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTE 454 Query: 281 DDWISSLQWHESRLQLLAATADT-SLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSG 339 + L S + A + D + VW + A Sbjct: 455 RIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLL----------------DALSGHE 498 Query: 340 GFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEY 399 G SCL F+ E + + R+W+ Q++ DV ++ P G+ Sbjct: 499 GPVSCLSFSQENSV-LASASWDKTIRIWSIFGR---SQQVEPIEVYSDVLALSMRPDGKE 554 Query: 400 LLATSLDQTTRLF----APWIYDASGRKREIATWHEFSRPQIHG-----YDMICVETVTD 450 + ++L +F A + + RK I+ R + + Sbjct: 555 VAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDG 614 Query: 451 TRFVSGGDEKILRSFDLPKGVAGMLQKFV---------GIQFEEKSEMPDSATVPVLGLS 501 V+GG+ + +D+P V +L++F+ ++F +M ++ ++ ++ Sbjct: 615 MAIVAGGNNNSICLYDVPNEV--LLKRFIVSRNMALNGTLEFLNSKKMTEAGSLDLI--- 669 Query: 502 NKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEI 561 DDA E+ + E + D + P S L + PEV + Sbjct: 670 -----DDAGENSDLE-----DRIDNSLPGS-----QRGGDLSTRKMRPEVR--------V 706 Query: 562 TCLDISPDQKLIASAC 577 T + SP A+A Sbjct: 707 TSVQFSPTANAFAAAS 722 Score = 113 bits (282), Expect = 3e-25, Method: Composition-based stats. Identities = 95/675 (14%), Positives = 200/675 (29%), Gaps = 123/675 (18%) Query: 17 QTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVS 76 Q ++ K++++ + ++++D I + H + + ++S Sbjct: 42 QGNITFSDDGKQLLSPVGNR-VSVFDLINNKSFTFEYE---HRKNIAAIDLNKQGTLLIS 97 Query: 77 ASEDHHVKIWKFTDYSHLQCIQTIQHY-----SKTIVALSALPSLISVGCADGTISIWRQ 131 ED + F + + H+ + V S L ++ + IW+ Sbjct: 98 IDEDGRAILVNF-------KARNVLHHFNFKEKCSAVKFSPDGRLFALASG-RFLQIWKT 149 Query: 132 -NIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIE 190 ++ D + SL+ ++ +++L +++ I S + + Sbjct: 150 PDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTT-SKDLSAKIWSVDSEEKNLA 208 Query: 191 KCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKK 250 GH D+V F H + + S+D + +W DD E Sbjct: 209 A----TTFNGHRDYVMGAFFSH----DQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDD 260 Query: 251 LTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEP 310 I + + + + +H + L +++ Sbjct: 261 DK-QEEVDISKYSWR-----ITKKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDL 314 Query: 311 DETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRM--WA 368 + + I S+ + + + +G + + + K G + W Sbjct: 315 PDFTLIQQLSMG----QNPVNTVSVNQTGEWLA------------FGSSKLGQLLVYEWQ 358 Query: 369 TKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIAT 428 ++ I+ Q G +A+SP G ++ S D + ++D + Sbjct: 359 SESYILKQQ-----GHFDSTNSLAYSPDGSRVVTASEDGKIK-----VWDIT----SGFC 404 Query: 429 WHEFSRPQIHGYDMICVE-TVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVG---IQFE 484 F H + V+ S + +R++DL + + F G IQF Sbjct: 405 LATFEE---HTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIR--YRNFRTFTGTERIQFN 459 Query: 485 EKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDI----TDPLSLLECPPMED 540 + P V L N DI LL+ Sbjct: 460 CLAVDPSGEVVCAGSLDNF---------------------DIHVWSVQTGQLLDA----- 493 Query: 541 QLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKP 600 L GH ++CL S + ++ASA IRI+S + Sbjct: 494 -------------LSGHEGPVSCLSFSQENSVLASASWDKT-----IRIWSIFGRSQQVE 535 Query: 601 ALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDAD 660 + +S + L DGK + + +++ + + + R D Sbjct: 536 PIEVYSD-VLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRF 594 Query: 661 WAPLEFGNVFVTASR 675 A + F T Sbjct: 595 TAKNSERSKFFTTIH 609 Score = 86.5 bits (212), Expect = 4e-17, Method: Composition-based stats. Identities = 102/555 (18%), Positives = 171/555 (30%), Gaps = 108/555 (19%) Query: 243 DSEEDSKKLTLLSNKQYKFQIDDELRV-GINFEALIMGH----DDWISSLQWHESRLQLL 297 + ++ + L ID++ R +NF+A + H + S++++ Sbjct: 78 EHRKNIAAIDLNKQGTLLISIDEDGRAILVNFKARNVLHHFNFKEKCSAVKFSPDGRLFA 137 Query: 298 AATADTSLMVWE-PDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFL 356 A+ L +W+ PD G S W R F L Sbjct: 138 LASGRF-LQIWKTPDVNKDRQFAPF-------VRHRVHAGHFQDITSLTWSQDSR--FIL 187 Query: 357 TNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFA--- 413 T K S ++W+ +G V +S E + S D ++ Sbjct: 188 TTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTK 247 Query: 414 ---------------PWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGD 458 D S I H F Q + CV TR ++ G Sbjct: 248 RPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAK---VKCVTFHPATRLLAVGF 304 Query: 459 EK-ILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEE 517 R +DLP F IQ + P + TV V N+ GE A Sbjct: 305 TSGEFRLYDLP--------DFTLIQQLSMGQNPVN-TVSV----NQTGEWLAF------- 344 Query: 518 GGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASAC 577 G +K L + E Q + ++L K GH L SPD + +A Sbjct: 345 GSSK----------LGQLLVYEWQSESYIL-----KQQGHFDSTNSLAYSPDGSRVVTAS 389 Query: 578 RSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNM 637 I+++ + + H+ ++T ++F+K G+ + S D W+ Sbjct: 390 EDGK-----IKVWDITSGFCL-ATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIR 443 Query: 638 EDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDK-TVKVWRHQKEPADDYVLEA 696 N T I A G V S D + VW Q +L+A Sbjct: 444 YRNFRTFTG------TERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQ----TGQLLDA 493 Query: 697 SIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKFELITQL---NEDITPAD 753 H V+ +S L S + K I + ++ + P + Sbjct: 494 LSGHEGPVSCLSFSQENS---------------VLASASWDKTIRIWSIFGRSQQVEPIE 538 Query: 754 KITRLRWSHLKRNGK 768 + + ++ +GK Sbjct: 539 VYSDVLALSMRPDGK 553 Score = 80.7 bits (197), Expect = 2e-15, Method: Composition-based stats. Identities = 58/366 (15%), Positives = 109/366 (29%), Gaps = 90/366 (24%) Query: 15 NKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFM 74 + ++ ++V I +WD + AT + H + VT V+F M Sbjct: 371 DSTNSLAYSPDGSRVVTASEDGKIKVWDI---TSGFCLATFEEHTSSVTAVQFAKRGQVM 427 Query: 75 VSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADG-TISIWRQNI 133 S+S D V+ W Y + + + +A+ ++ G D I +W Sbjct: 428 FSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQT 487 Query: 134 QNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCR 193 L + +G CLS S+ +LA + + I S +E Sbjct: 488 GQ----LLDALSGHEGP--VSCLSFSQENS---VLASASWDKTIRIWSIFGRSQQVEPIE 538 Query: 194 V-----------------VAELEGHED-----------------WVKSLAFRHQETP--- 216 V V+ L+G + S F Sbjct: 539 VYSDVLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKN 598 Query: 217 --------------GDYLLCSGSQDRYIRLWRIRINDLIDDSEE-------------DSK 249 + +G + I L+ + L+ +SK Sbjct: 599 SERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRFIVSRNMALNGTLEFLNSK 658 Query: 250 KLTLLS----------NKQYKFQIDDEL---RVGINFEALIMGHDDWISSLQWHESRLQL 296 K+T N + +ID+ L + G + M + ++S+Q+ + Sbjct: 659 KMTEAGSLDLIDDAGENSDLEDRIDNSLPGSQRGGDLSTRKMRPEVRVTSVQFSPTANAF 718 Query: 297 LAATAD 302 AA+ + Sbjct: 719 AAASTE 724 Score = 59.1 bits (141), Expect = 8e-09, Method: Composition-based stats. Identities = 38/237 (16%), Positives = 89/237 (37%), Gaps = 31/237 (13%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 +++L + + ++ + +A + + ++ + +E+++ + H + Sbjct: 320 IQQLSMGQNPVNTVSVNQTGEWLAFGS--SKLGQLLVYEWQSESYILKQ---QGHFDSTN 374 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVF 670 L +S DG +++ D K +W+ + HT + +A G V Sbjct: 375 SLAYSPDGSRVVTASEDGKIKVWDITSGFCLATF-----EEHTSSVTAVQFAKR--GQVM 427 Query: 671 VTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIRE--KILISVGLENGE 728 ++S D TV+ W Y + T+ I + + +++ + L+N + Sbjct: 428 FSSSLDGTVRAWDL-----IRYRNFRTFTGTE---RIQFNCLAVDPSGEVVCAGSLDNFD 479 Query: 729 IYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYSL 785 I+++S G+ D + S + N L S D + RI+S+ Sbjct: 480 IHVWSVQTGQLL-------DALSGHEGPVSCLSFSQENS--VLASASWDKTIRIWSI 527 >5NZU-C nrPDB Length = 905 Score = 148 bits (372), Expect = 1e-35, Method: Composition-based stats. Identities = 59/325 (18%), Positives = 117/325 (36%), Gaps = 36/325 (11%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 +V I +++ N + H + C+ P F++++S+D +K+W + Sbjct: 72 VVTGADDMQIRVFN---YNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDW 128 Query: 89 -TDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGL-AHEFTI 146 +S Q + HY IV + + D TI +W+ + F L HE + Sbjct: 129 DKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGV 188 Query: 147 KKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVK 206 C+ +K YL++ G + V I + + V LEGH V Sbjct: 189 N-------CIDYYSGGDKPYLIS-GADDRLVKIWDY-------QNKTCVQTLEGHAQNVS 233 Query: 207 SLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKL----TLLSNKQYKFQ 262 +F + ++ +GS+D +R+W L +++ +L + Sbjct: 234 CASFHPEL----PIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALG 289 Query: 263 IDDE---LRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVC 319 D+ +++G A+ M + I + E + L A DT + + + + Sbjct: 290 YDEGSIIVKLGREEPAMSMDANGKIIWAKHSEVQQANLKAMGDTEIK-----DGERLPLA 344 Query: 320 SLRLGEMSSKGASTATGSSGGFWSC 344 +G + +G F Sbjct: 345 VKDMGSCEIYPQTIQHNPNGRFVVV 369 Score = 121 bits (303), Expect = 1e-27, Method: Composition-based stats. Identities = 60/329 (18%), Positives = 115/329 (34%), Gaps = 27/329 (8%) Query: 10 IFIGANKQTQVSDIH--KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRF 67 +F G I+ + + +TI +W + TL+GHE V C+ + Sbjct: 137 VFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPN---FTLEGHEKGVNCIDY 193 Query: 68 VPDSD--FMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSL--ISVGCAD 123 D +++S ++D VKIW DY + C+QT++ +++ + S P L I G D Sbjct: 194 YSGGDKPYLISGADDRLVKIW---DYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSED 250 Query: 124 GTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFI 183 GT+ IW + E T+ G C++ S L ++ V + Sbjct: 251 GTVRIWHSST------YRLESTLNYGMERVWCVA-SLRGSNNVALGYDEGSIIVKLGREE 303 Query: 184 LSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDD 243 + S +++ A E L +D + I Sbjct: 304 PAMSMDANGKIIWAKHSEVQQANLKAMGDTEIKDGERLPLAVKD----MGSCEIYPQTIQ 359 Query: 244 SEEDSKKLTLLSNKQYKFQIDDELRVGI--NFEALIMGHDDWISSLQWHESRLQLLAATA 301 + + + + + +Y LR + + HD +++ S +++ Sbjct: 360 HNPNGRFVVVCGDGEYIIYTAMALRNKSFGSAQEFAWAHDSSEYAIRESNSIVKIFKNFK 419 Query: 302 DTSLMVWEPDETSGIWVCSLRLGEMSSKG 330 + ++PD + LG S G Sbjct: 420 EK--KSFKPDFGAESIYGGFLLGVRSVNG 446 Score = 109 bits (272), Expect = 5e-24, Method: Composition-based stats. Identities = 42/326 (12%), Positives = 101/326 (30%), Gaps = 75/326 (23%) Query: 53 ATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSA 112 L V V P +M+++ + V +W ++ ++T + + A Sbjct: 9 RKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVW---NHETQTLVKTFEVCDLPVRAAKF 65 Query: 113 --LPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAI 170 + + G D I ++ N H F Y C+++ + + Sbjct: 66 VARKNWVVTGADDMQIRVFNYNTLE----RVHMFEAHSD--YIRCIAVHPTQP---FILT 116 Query: 171 GGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYI 230 ++ + + + +K EGH +V + + + S S DR I Sbjct: 117 SSDDMLIKLWDW------DKKWSCSQVFEGHTHYVMQIVINPK---DNNQFASASLDRTI 167 Query: 231 RLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWH 290 ++W++ + + GH+ ++ + ++ Sbjct: 168 KVWQL---------------------------------GSSSPNFTLEGHEKGVNCIDYY 194 Query: 291 E--SRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFT 348 + L++ D + +W+ + + G + SC F Sbjct: 195 SGGDKPYLISGADDRLVKIWDYQNKTCVQTLE---------------GHAQNV-SCASF- 237 Query: 349 HERMDFFLTNGKTGSWRMWATKDNII 374 H + +T + G+ R+W + + Sbjct: 238 HPELPIIITGSEDGTVRIWHSSTYRL 263 Score = 88.0 bits (216), Expect = 1e-17, Method: Composition-based stats. Identities = 27/126 (21%), Positives = 53/126 (42%), Gaps = 7/126 (5%) Query: 6 TPEAIFIGANKQTQVSDIHKVKK---IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEV 62 +P G K D + +++ + + +WD NK TL+GH V Sbjct: 176 SPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWD---YQNKTCVQTLEGHAQNV 232 Query: 63 TCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCA 122 +C F P+ +++ SED V+IW + Y + + +L + +++G Sbjct: 233 SCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNN-VALGYD 291 Query: 123 DGTISI 128 +G+I + Sbjct: 292 EGSIIV 297 Score = 86.1 bits (211), Expect = 6e-17, Method: Composition-based stats. Identities = 35/227 (15%), Positives = 80/227 (35%), Gaps = 35/227 (15%) Query: 548 WPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFS-TENWLEIKPALPFHS 606 V H I C+ + P Q I ++ + +I+++ + W + H+ Sbjct: 89 LERVHMFEAHSDYIRCIAVHPTQPFILTSS-----DDMLIKLWDWDKKWSCSQV-FEGHT 142 Query: 607 LTITRLKFSK-DGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLE 665 + ++ + D S DR +W+ F L + + + P Sbjct: 143 HYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKP-- 200 Query: 666 FGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLE 725 ++ + D+ VK+W +Q + ++ H + V+ S H + +I G E Sbjct: 201 ---YLISGADDRLVKIWDYQNKTC----VQTLEGHAQNVSCASFHPELP----IIITGSE 249 Query: 726 NGEIYLY-----------SYTLGKFELITQL---NEDITPADKITRL 758 +G + ++ +Y + + + L N D+ + + Sbjct: 250 DGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSII 296 Score = 85.3 bits (209), Expect = 1e-16, Method: Composition-based stats. Identities = 44/323 (13%), Positives = 105/323 (32%), Gaps = 73/323 (22%) Query: 98 QTIQHYSKTIVALSALP--SLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLC 155 + + S + ++ P + +G++ +W Q L F + L Sbjct: 9 RKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQT----LVKTFEV-----CDLP 59 Query: 156 LSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQET 215 + +K +K + G ++ + + ++ V E H D+++ +A Sbjct: 60 VRAAKFVARKNWVVTGADDMQIRVFNY-------NTLERVHMFEAHSDYIRCIAVH---- 108 Query: 216 PGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEA 275 P + + S D I+LW ++ + Sbjct: 109 PTQPFILTSSDDMLIKLWD--------------WDKKWSCSQVF---------------- 138 Query: 276 LIMGHDDWISSLQWHE-SRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTA 334 GH ++ + + Q +A+ D ++ VW+ +S + Sbjct: 139 --EGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLE-------------- 182 Query: 335 TGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWS 394 G G +++ + ++ ++W + N C Q + G ++V+ ++ Sbjct: 183 -GHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQ-NKTCVQ--TLEGHAQNVSCASFH 238 Query: 395 PSGEYLLATSLDQTTRLFAPWIY 417 P ++ S D T R++ Y Sbjct: 239 PELPIIITGSEDGTVRIWHSSTY 261 Score = 65.3 bits (157), Expect = 1e-10, Method: Composition-based stats. Identities = 33/231 (14%), Positives = 78/231 (33%), Gaps = 47/231 (20%) Query: 267 LRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSL-RLGE 325 + + ++ + + D + S+ H + +LA+ + S+ VW + + + + L Sbjct: 1 MPLRLDIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPV 60 Query: 326 MSSKGASTAT-------------------------GSSGGFWSCLWFTHERMDFFLTNGK 360 ++K + + + C+ H F LT+ Sbjct: 61 RAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAV-HPTQPFILTSSD 119 Query: 361 TGSWRMWATKDNIICDQRLGISGATKDVTDIAWSP-SGEYLLATSLDQTTRLF----APW 415 ++W C Q G T V I +P + SLD+T +++ + Sbjct: 120 DMLIKLWDWDKKWSCSQVFE--GHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSP 177 Query: 416 IYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFD 466 + G ++ + +S +SG D+++++ +D Sbjct: 178 NFTLEGHEKGVNCIDYYSGG-------------DKPYLISGADDRLVKIWD 215 Score = 59.5 bits (142), Expect = 5e-09, Method: Composition-based stats. Identities = 43/209 (20%), Positives = 72/209 (34%), Gaps = 32/209 (15%) Query: 583 QNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERN---MED 639 + IR+F+ N LE HS I + F+L+ D LW+ + Sbjct: 77 DDMQIRVFN-YNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCS 135 Query: 640 NTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIK 699 FE HT + P + N F +AS D+T+KVW+ + ++ LE Sbjct: 136 QVFE-------GHTHYVMQIVINPKDN-NQFASASLDRTIKVWQL-GSSSPNFTLE---G 183 Query: 700 HTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKFELI---TQLNED-------- 748 H K V I + + ++ G ++ + ++ Y N Sbjct: 184 HEKGVNCIDYYSGGDKPYLIS--GADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPEL 241 Query: 749 ---ITPADKITRLRWSHLKRNGKLFLGVG 774 IT ++ T W + L G Sbjct: 242 PIIITGSEDGTVRIWHSSTYRLESTLNYG 270 >5OQL-J nrPDB Length = 912 Score = 147 bits (371), Expect = 2e-35, Method: Composition-based stats. Identities = 85/502 (16%), Positives = 168/502 (33%), Gaps = 93/502 (18%) Query: 29 IVAFGAGKTIALW---DPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKI 85 +++ KT+ LW D I + L + V F+ + +M SA ++I Sbjct: 247 LLSGSRDKTMTLWLWRDGIWQGTPMLRHEL------LESVGFLNEGKWMYSAGTSGVLRI 300 Query: 86 WKFTDYSHLQCIQTIQHYSKTIVALSALP--SLISVGCADGTISIWRQ----NIQNDEFG 139 W T + + Q + + I++ +LP SLI AD T+ ++R ++ + G Sbjct: 301 WDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILCAQADFTLVLYRVPSPADVVSSSEG 360 Query: 140 LAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEK---CRV-- 194 + E + + L L+ + + ++AI + ++ I S + + E CR Sbjct: 361 ILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGS 420 Query: 195 -----VAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI-------RINDLID 242 VA L+GHED V SL + + SGS+D RLWR+ + Sbjct: 421 YFGHDVALLKGHEDIVMSLDVDWS----GHWIASGSKDNTARLWRVDPANNSYTCYAVFT 476 Query: 243 DSEEDSKKLTL------LSNKQYKFQIDDELRVGI-----------------------NF 273 E + L +++ +K +D I Sbjct: 477 GHLESVGAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTS 536 Query: 274 EALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGAST 333 + HD I++L + +A+ D ++ +W+ ++ + G Sbjct: 537 SLRRLAHDKDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGILR---GHKRGVWTVR 593 Query: 334 ATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAW 393 + + LT + ++W D G + +V + W Sbjct: 594 FAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIR---TFEGHSHNVLKVVW 650 Query: 394 ---------SPSGEYLLATSLDQTTRLFAPWIYDA-SGRKREIATWHEFSRPQIHGYDMI 443 + + + D + ++DA +G HE + Sbjct: 651 LHISRDDSITKTKVQFASAGADTLVK-----VWDANTGETECTLDNHE------DRLWTL 699 Query: 444 CVETVTDTRFVSGGDEKILRSF 465 V + T+ S G + + + Sbjct: 700 AVHSKTN-ILASAGSDSKVTFW 720 Score = 112 bits (280), Expect = 5e-25, Method: Composition-based stats. Identities = 133/818 (16%), Positives = 244/818 (29%), Gaps = 194/818 (23%) Query: 23 IHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHH 82 + +I+A G+ L E N A ++G ++ + P ++ S Sbjct: 28 LENGARILASTLGENAIL---TELNTGKRLAEIQGDGEPISTLTITPSGSHLIVCSRSLT 84 Query: 83 VKIWKFT-----DYSHLQCIQTIQHYSKTIV--ALSALPSLISVGCADGTISIWRQNIQN 135 ++I+ D ++T + ++ +V A+ +L++ G ADG I IW Sbjct: 85 MRIYSLAISPDYDSVEPTLVRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIGGY 144 Query: 136 DEFGL----AHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEK 191 + + S S ++ K G + IAS G + Sbjct: 145 VTHTVSGPSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQD 204 Query: 192 CRV-----------------VAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW- 233 R+ + E HE V+ +A+ ++ + L SGS+D+ + LW Sbjct: 205 GRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQ----HALLSGSRDKTMTLWL 260 Query: 234 ------------RIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHD 281 R + + + E + +I D + + Sbjct: 261 WRDGIWQGTPMLRHELLESVGFLNEGKW--MYSAGTSGVLRIWDTTTHHEITKKQDAKSE 318 Query: 282 DW-ISSLQWHESRLQLLAATADTSLMVWE-PDETSGIWVCSLRLGEMSSKGASTATGSSG 339 I S R +L A AD +L+++ P + L E + + G+ Sbjct: 319 GEAILSAVSLPERSLILCAQADFTLVLYRVPSPADVVSSSEGILLEPFRRIS----GTHD 374 Query: 340 GFWSCLW-FTHERMDFFLTNGKTGSW-----RMWATKDNIICDQRLGI-------SGATK 386 + + M TN + ++DN C G Sbjct: 375 EILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHED 434 Query: 387 DVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVE 446 V + SG ++ + S D T RL + + F + V Sbjct: 435 IVMSLDVDWSGHWIASGSKDNTARL-----WRVDPANNSYTCYAVF------TGHLESVG 483 Query: 447 TVTDTRFVSGGDEKILRS-FDLPKG--VAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNK 503 V + V + + ++ D P ++G +FV +K ++P Sbjct: 484 AVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFV-----QKRDIPR------------ 526 Query: 504 AGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITC 563 + ++GG + L+R H +I Sbjct: 527 ----------QLQKGGK-----------------LTSSLRR----------LAHDKDINA 549 Query: 564 LDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLS 623 LDISP+ KL ASA Q+ ++I+ E LE++ L H + ++F+ Sbjct: 550 LDISPNGKLFASAS-----QDKTVKIWDVEK-LEVQGILRGHKRGVWTVRFAP------- 596 Query: 624 VCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWR 683 + E+ V +T S DKT+K+W Sbjct: 597 -----------------LNTPVIQGEQGSVS-----------GRGVVLTGSGDKTIKLWN 628 Query: 684 HQKEPADDYVLEASI-KHTKAVTAISI-HDSMIREKILISVGLENGEIYLYSYTLGKFEL 741 DY + H+ V + H S + ++ S Sbjct: 629 L-----SDYTCIRTFEGHSHNVLKVVWLHISR-------DDSITKTKVQFASAGADTLVK 676 Query: 742 ITQLN--EDITPADKITRLRWSHLKRNGKLFLGVGSSD 777 + N E D W+ + L SD Sbjct: 677 VWDANTGETECTLDNHEDRLWTLAVHSKTNILASAGSD 714 Score = 107 bits (266), Expect = 2e-23, Method: Composition-based stats. Identities = 106/735 (14%), Positives = 221/735 (30%), Gaps = 141/735 (19%) Query: 15 NKQTQVSDIHKVKKIVAFGAGKTIALWDP-----IEPNNKGVYATLKGHEAEVTCVRFVP 69 + ++ ++ T+ ++ + + T K H V + Sbjct: 62 EPISTLTITPSGSHLIVCSRSLTMRIYSLAISPDYDSVEPTLVRTTKPHATPVVVLAVDR 121 Query: 70 DSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIW 129 S + + + D +KIW + + PS++ + + Sbjct: 122 TSTLLATGAADGAIKIWDIIGGY--------------VTHTVSGPSVLVSA-----LHFF 162 Query: 130 RQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGI 189 + + + + ++ LA G + + I + Sbjct: 163 EIAVTAESQSSNKKPKKGSRKGQN---DDADEIASRFRLAWGTQDGRIRIFDLYKRTTTP 219 Query: 190 EKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW-------------RIR 236 + E HE V+ +A+ ++ + L SGS+D+ + LW R Sbjct: 220 VYADPKRKKEAHESNVQCIAYSPEQ----HALLSGSRDKTMTLWLWRDGIWQGTPMLRHE 275 Query: 237 INDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDW-ISSLQWHESRLQ 295 + + + E + +I D + + I S R Sbjct: 276 LLESVGFLNEGKW--MYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSL 333 Query: 296 LLAATADTSLMVWE-PDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLW-FTHERMD 353 +L A AD +L+++ P + L E + + G+ + + M Sbjct: 334 ILCAQADFTLVLYRVPSPADVVSSSEGILLEPFRRIS----GTHDEILDLTYILPDQSMM 389 Query: 354 FFLTNGKTGSW-----RMWATKDNIICDQRLGI-------SGATKDVTDIAWSPSGEYLL 401 TN + ++DN C G V + SG ++ Sbjct: 390 AIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIA 449 Query: 402 ATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMI---CVETVTDTR------ 452 + S D T RL+ + S + T H S + ++ E + Sbjct: 450 SGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLDHPPAF 509 Query: 453 FVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANED 512 +SG ++ ++ D+P+ Q ++ ++ S L A + D N Sbjct: 510 LISGSQDRFVQKRDIPR------------QLQKGGKLTSS-------LRRLAHDKDIN-- 548 Query: 513 DEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEK------LYGHGFEITCLDI 566 DI+ L + ++ +W +VEK L GH + + Sbjct: 549 ----------ALDISPNGKLFASASQDKTVK---IW-DVEKLEVQGILRGHKRGVWTVRF 594 Query: 567 SPDQKLIASACRSN---------NVQNAVIRIFSTENWLEIKPALPFHSLTITRLKF--- 614 +P + + + + I++++ ++ I+ HS + ++ + Sbjct: 595 APLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIR-TFEGHSHNVLKVVWLHI 653 Query: 615 SKDGKF------LLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGN 668 S+D S D +W+ N + E N H +W A N Sbjct: 654 SRDDSITKTKVQFASAGADTLVKVWDANTGET--ECTLDN---HEDRLWT--LAVHSKTN 706 Query: 669 VFVTASRDKTVKVWR 683 + +A D V WR Sbjct: 707 ILASAGSDSKVTFWR 721 Score = 99 bits (247), Expect = 4e-21, Method: Composition-based stats. Identities = 82/552 (14%), Positives = 162/552 (29%), Gaps = 129/552 (23%) Query: 14 ANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRF------ 67 A ++ + A I +WD I V T+ G V+ + F Sbjct: 111 ATPVVVLAVDRTSTLLATGAADGAIKIWDIIGG---YVTHTVSGPSVLVSALHFFEIAVT 167 Query: 68 ------------------VPDSDFMVS------ASEDHHVKIWKF----TDYSHLQCIQT 99 D+D + S ++D ++I+ T + + Sbjct: 168 AESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRK 227 Query: 100 IQHYSKTIVALSALPSL--ISVGCADG--TISIWRQNIQNDEFGLAHEFTIKKGFFYPLC 155 + + + ++ P + G D T+ +WR I L HE L Sbjct: 228 KEAHESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDGIWQGTPMLRHE----------LL 277 Query: 156 LSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQET 215 S+ + E K++ + G T+ + I +K +E E Sbjct: 278 ESVGFLNEGKWMYSAG-TSGVLRIWDTTTHHEITKKQDAKSEGE--------AILSAVSL 328 Query: 216 PGDYLLCSGSQDRYIRLWR---------------IRINDLIDDSEEDSKKLTLLSNKQYK 260 P L+ D + L+R + I + ++ LT + Q Sbjct: 329 PERSLILCAQADFTLVLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSM 388 Query: 261 FQI---------------------DDELRVGINF---EALIMGHDDWISSLQWHESRLQL 296 I + E R G F AL+ GH+D + SL S + Sbjct: 389 MAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWI 448 Query: 297 LAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHER---MD 353 + + D + +W D + + C + A + F + Sbjct: 449 ASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLDHPPA 508 Query: 354 FFLTNGKTGSWRMWATKDNIICDQRLGIS----GATKDVTDIAWSPSGEYLLATSLDQTT 409 F ++ + + + +L S KD+ + SP+G+ + S D+T Sbjct: 509 FLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQDKTV 568 Query: 410 RLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRF-------------VSG 456 +++ + G R G + + ++G Sbjct: 569 KIWDVEKLEVQG----------ILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTG 618 Query: 457 GDEKILRSFDLP 468 +K ++ ++L Sbjct: 619 SGDKTIKLWNLS 630 Score = 98.8 bits (244), Expect = 9e-21, Method: Composition-based stats. Identities = 36/228 (15%), Positives = 71/228 (31%), Gaps = 36/228 (15%) Query: 29 IVAFGAGKTIALWDPIEPNNK--GVYATLK--GHEAEVTCVRFVPDSDFMVSASEDHHVK 84 +++ + + D K + ++L+ H+ ++ + P+ SAS+D VK Sbjct: 510 LISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQDKTVK 569 Query: 85 IWKFTDYSHLQCIQTIQHYSKTIVALSALPSLI-------------SVGCADGTISIWRQ 131 IW ++ + T+ +I G D TI +W Sbjct: 570 IWDVEKLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNL 629 Query: 132 NIQNDEFGLAHEFTIKKGF----FYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDS 187 + ++ F + + + K A G + V + Sbjct: 630 S----DYTCIRTFEGHSHNVLKVVWLHISRDDSITKTKVQFASAGADTLVKVW------- 678 Query: 188 GIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI 235 L+ HED + +LA + +L S D + WR Sbjct: 679 DANTGETECTLDNHEDRLWTLAVHSKTN----ILASAGSDSKVTFWRD 722 >6G51-g nrPDB Length = 317 Score = 147 bits (370), Expect = 2e-35, Method: Composition-based stats. Identities = 55/331 (16%), Positives = 101/331 (30%), Gaps = 42/331 (12%) Query: 1 MVECITPEAIFIGANKQTQVSDIHKV--KKIVAFGAGKTIALWDPIEPNNKGVY--ATLK 56 M E +T G N I++ KTI +W L+ Sbjct: 1 MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR 60 Query: 57 GHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS- 115 GH V+ V D F +S S D +++W T + + ++K +++++ Sbjct: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTT---RRFVGHTKDVLSVAFSSDN 117 Query: 116 -LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTN 174 I G D TI +W + + + C+ S +++ G Sbjct: 118 RQIVSGSRDKTIKLWNTLG-----VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCG--- 169 Query: 175 VNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWR 234 ++ + C++ GH ++ ++ P L SG +D LW Sbjct: 170 -----WDKLVKVWNLANCKLKTNHIGHTGYLNTVTVS----PDGSLCASGGKDGQAMLWD 220 Query: 235 IRIND--LIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIM-------------- 278 + D + L N+ + + E I+ Sbjct: 221 LNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSK 280 Query: 279 GHDDWISSLQWHESRLQLLAATADTSLMVWE 309 +SL W L A D + VW+ Sbjct: 281 AEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 Score = 127 bits (318), Expect = 2e-29, Method: Composition-based stats. Identities = 65/383 (16%), Positives = 131/383 (34%), Gaps = 82/383 (21%) Query: 46 PNNKGVYATLKGHEAEVTCVRFVPD-SDFMVSASEDHHVKIW----KFTDYSHLQC-IQT 99 + TLKGH VT + P D ++SAS D + +W T+Y Q ++ Sbjct: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 Query: 100 IQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLS 159 H+ +V +S+ G DGT+ +W T + LS++ Sbjct: 62 HSHFVSDVV-ISSDGQFALSGSWDGTLRLWDLTTG--------TTTRRFVGHTKDVLSVA 112 Query: 160 KVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDY 219 + + +++ G + + + + + C+ + E H +WV + F + + Sbjct: 113 FSSDNRQIVS-GSRDKTIKLWNT------LGVCKYTVQDESHSEWVSCVRFSPNSS--NP 163 Query: 220 LLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMG 279 ++ S D+ +++W + L + +G Sbjct: 164 IIVSCGWDKLVKVWNLANCKLKTNH---------------------------------IG 190 Query: 280 HDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSG 339 H +++++ + D M+W+ +E ++ G Sbjct: 191 HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL-----------------DGG 233 Query: 340 GFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQ------RLGISGATKDVTDIAW 393 + L F+ R ++L S ++W + II D+ T +AW Sbjct: 234 DIINALCFSPNR--YWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAW 291 Query: 394 SPSGEYLLATSLDQTTRLFAPWI 416 S G+ L A D R++ I Sbjct: 292 SADGQTLFAGYTDNLVRVWQVTI 314 Score = 108 bits (270), Expect = 8e-24, Method: Composition-based stats. Identities = 36/202 (17%), Positives = 83/202 (41%), Gaps = 30/202 (14%) Query: 271 INFEALIMGHDDWISSLQWHESRL-QLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSK 329 + + GH+ W++ + +L+A+ D ++++W+ + + + + + Sbjct: 5 MTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDE----TNYGIPQRALR 60 Query: 330 GASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVT 389 G S F S + + + F L+ G+ R+W + G TKDV Sbjct: 61 GHS-------HFVSDVVISSDGQ-FALSGSWDGTLRLWDLTTGTTTRR---FVGHTKDVL 109 Query: 390 DIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVE--- 446 +A+S +++ S D+T +L ++ G + + + H + CV Sbjct: 110 SVAFSSDNRQIVSGSRDKTIKL-----WNTLG-----VCKYTV-QDESHSEWVSCVRFSP 158 Query: 447 TVTDTRFVSGGDEKILRSFDLP 468 ++ VS G +K+++ ++L Sbjct: 159 NSSNPIIVSCGWDKLVKVWNLA 180 Score = 93.4 bits (230), Expect = 3e-19, Method: Composition-based stats. Identities = 38/170 (22%), Positives = 64/170 (37%), Gaps = 12/170 (7%) Query: 554 LYGHGFEITCLDISPD-QKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRL 612 L GH +T + +P +I SA R + + T + + AL HS ++ + Sbjct: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQR-ALRGHSHFVSDV 69 Query: 613 KFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVT 672 S DG+F LS D LW+ + HT+ + A V+ Sbjct: 70 VISSDGQFALSGSWDGTLRLWDLTTGT-----TTRRFVGHTKDVLSV--AFSSDNRQIVS 122 Query: 673 ASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISV 722 SRDKT+K+W E+ H++ V+ + + I+ Sbjct: 123 GSRDKTIKLWNTLGVCKYTVQDES---HSEWVSCVRFSPNSSNPIIVSCG 169 Score = 69.5 bits (168), Expect = 5e-12, Method: Composition-based stats. Identities = 64/373 (17%), Positives = 136/373 (36%), Gaps = 73/373 (19%) Query: 378 RLGISGATKDVTDIAWSPS-GEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRP- 435 R + G VT IA +P + +L+ S D+T ++ R+ + R Sbjct: 8 RGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKL--------TRDETNYGIPQRAL 59 Query: 436 QIHGYDMICVETVTDTRF-VSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSAT 494 + H + + V +D +F +SG + LR +DL G ++FVG T Sbjct: 60 RGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTT--TRRFVG------------HT 105 Query: 495 VPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKL 554 VL ++ ++++ + G +T + + L + + ++ Sbjct: 106 KDVLSVAF------SSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDES------------- 146 Query: 555 YGHGFEITCLDISPDQK--LIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRL 612 H ++C+ SP+ +I S + ++++++ N ++K H+ + + Sbjct: 147 --HSEWVSCVRFSPNSSNPIIVSCGW-----DKLVKVWNLAN-CKLKTNHIGHTGYLNTV 198 Query: 613 KFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVT 672 S DG S +D + LW+ N + + L + II ++P + T Sbjct: 199 TVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL----DGGD--IINALCFSPNRYWLCAAT 252 Query: 673 ASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLY 732 ++K+W + + D + + IS + +G+ Sbjct: 253 GP---SIKIWDLEGKIIVDELKQEV---------ISTSSKAEPPQCTSLAWSADGQTLFA 300 Query: 733 SYTLGKFELITQL 745 YT + Q+ Sbjct: 301 GYT-DNLVRVWQV 312 Score = 54.9 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 61/357 (17%), Positives = 117/357 (32%), Gaps = 100/357 (28%) Query: 333 TATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWAT---KDNIICDQRLGISGATKDVT 389 T G +G + + + T + D L+ + + MW + N QR + G + V+ Sbjct: 10 TLKGHNG-WVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQR-ALRGHSHFVS 67 Query: 390 DIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVE-TV 448 D+ S G++ L+ S D T RL+ ++ T R H D++ V + Sbjct: 68 DVVISSDGQFALSGSWDGTLRLW------------DLTTGTTTRRFVGHTKDVLSVAFSS 115 Query: 449 TDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDD 508 + + VSG +K ++ ++ LG+ +D Sbjct: 116 DNRQIVSGSRDKTIKLWN------------------------------TLGVCKYTVQD- 144 Query: 509 ANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLY---GHGFEITCLD 565 E E + +P+ ++P+ ++ C D+L + + GH + + Sbjct: 145 --ESHSEWVSCVRFSPNSSNPI-IVSCG--WDKLVKVWNLANCKLKTNHIGHTGYLNTVT 199 Query: 566 ISPDQKLIASACRSNNVQNA-----------------------------------VIRIF 590 +SPD L AS + I+I+ Sbjct: 200 VSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIW 259 Query: 591 STENWL--------EIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMED 639 E + I + T L +S DG+ L + D +W+ + Sbjct: 260 DLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 Score = 51.1 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 21/156 (13%), Positives = 38/156 (24%), Gaps = 51/156 (32%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 IV+ G K + +W+ N + GH + V PD S +D +W Sbjct: 165 IVSCGWDKLVKVWNL---ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL 221 Query: 89 TDYSHLQCIQTI----------------------------------------------QH 102 + HL + + Sbjct: 222 NEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKA 281 Query: 103 YSKTIVALSA--LPSLISVGCADGTISIWRQNIQND 136 +L+ + G D + +W+ I Sbjct: 282 EPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 Score = 35.3 bits (79), Expect = 0.11, Method: Composition-based stats. Identities = 12/69 (17%), Positives = 28/69 (40%), Gaps = 6/69 (8%) Query: 27 KKIVAFGAGKTIALWD------PIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASED 80 + + G +I +WD E + + + K + T + + D + + D Sbjct: 245 RYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTD 304 Query: 81 HHVKIWKFT 89 + V++W+ T Sbjct: 305 NLVRVWQVT 313 >3MKQ-A nrPDB Length = 814 Score = 146 bits (367), Expect = 4e-35, Method: Composition-based stats. Identities = 40/215 (18%), Positives = 81/215 (37%), Gaps = 25/215 (11%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 I+ I +++ + H + + P +++S S+D VK+W + Sbjct: 70 IIVGSDDFRIRVFNYNTGEK---VVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNW 126 Query: 89 T-DYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQ--NIQNDEFGLAHEFT 145 +++ Q + +H+ + PS + GC D T+ +W + N E Sbjct: 127 ENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERG 186 Query: 146 IKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWV 205 + +YPL +K Y++ ++ + I + + VA LEGH V Sbjct: 187 VNYVDYYPL-------PDKPYMI-TASDDLTIKIWDY-------QTKSCVATLEGHMSNV 231 Query: 206 KSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDL 240 F ++ SGS+D +++W + Sbjct: 232 SFAVFHPTL----PIIISGSEDGTLKIWNSSTYKV 262 Score = 116 bits (289), Expect = 5e-26, Method: Composition-based stats. Identities = 48/355 (13%), Positives = 112/355 (31%), Gaps = 75/355 (21%) Query: 53 ATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSA 112 T V + F P ++++ V+IW + ++ IQ + + ++ Sbjct: 7 KTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKFIAR 66 Query: 113 LPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGG 172 + I VG D I ++ N + +P + V K + G Sbjct: 67 K-NWIIVGSDDFRIRVFNYNTGEK---------VVDFEAHPDYIRSIAVHPTKPYVLSGS 116 Query: 173 TNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRL 232 ++ V + ++ + EGHE +V +AF + SG DR +++ Sbjct: 117 DDLTVKLWNWE------NNWALEQTFEGHEHFVMCVAFNPK---DPSTFASGCLDRTVKV 167 Query: 233 WRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWH-- 290 W L L G + ++ + ++ Sbjct: 168 WS--------------------------------LGQSTPNFTLTTGQERGVNYVDYYPL 195 Query: 291 ESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHE 350 + ++ A+ D ++ +W+ S + G ++ H Sbjct: 196 PDKPYMITASDDLTIKIWDYQTKSCVATLE---------------GHMSNVSFAVF--HP 238 Query: 351 RMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGE--YLLAT 403 + ++ + G+ ++W + + ++ + IA P+G Y+ + Sbjct: 239 TLPIIISGSEDGTLKIWNSSTYKVEK---TLNVGLERSWCIATHPTGRKNYIASG 290 Score = 85.7 bits (210), Expect = 7e-17, Method: Composition-based stats. Identities = 38/192 (19%), Positives = 73/192 (38%), Gaps = 18/192 (9%) Query: 550 EVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTI 609 +V H I + + P + + S + +++++ EN ++ H + Sbjct: 89 KVVDFEAHPDYIRSIAVHPTKPYVLSGS-----DDLTVKLWNWENNWALEQTFEGHEHFV 143 Query: 610 TRLKFSK-DGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGN 668 + F+ D S C DR +W F L R + D+ PL Sbjct: 144 MCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLT----TGQERGVNYVDYYPLPDKP 199 Query: 669 VFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGE 728 +TAS D T+K+W +Q + + H V+ H ++ +I G E+G Sbjct: 200 YMITASDDLTIKIWDYQTK----SCVATLEGHMSNVSFAVFHPTLP----IIISGSEDGT 251 Query: 729 IYLYSYTLGKFE 740 + +++ + K E Sbjct: 252 LKIWNSSTYKVE 263 Score = 84.6 bits (207), Expect = 1e-16, Method: Composition-based stats. Identities = 45/293 (15%), Positives = 96/293 (32%), Gaps = 59/293 (20%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 ++ TI +WD K ATL+GH + V+ F P ++S SED +KIW Sbjct: 201 MITASDDLTIKIWD---YQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNS 257 Query: 89 TDYSHLQCIQTIQHYSKTIVALSA-LPSLISVG-----------------CAD--GTISI 128 + Y + + S I + I+ G D G + + Sbjct: 258 STYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSLDPVGKL-V 316 Query: 129 W------------------RQNIQNDEFGLAHEFTIKKGFFYPLCLSLSK-------VEE 163 W + ++ DE + +P L+ S V + Sbjct: 317 WSGGKNAAASDIFTAVIRGNEEVEQDEPLSLQTKELGSVDVFPQSLAHSPNGRFVTVVGD 376 Query: 164 KKYLL--AIGGTNVNVFIASFILSDSGIEKCRVVAE---LEGHEDWVKSLAFRHQETPGD 218 +Y++ A+ N + ++ E ++ ++++ + ++ Sbjct: 377 GEYVIYTALAWRNKAFGKCQDFVWGPDSNSYALIDETGQIKYYKNFKEVTSWSVPMHSAI 436 Query: 219 YLLCSGS-----QDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDE 266 L SG+ D ++ + L+ + ++K + N + ++ Sbjct: 437 DRLFSGALLGVKSDGFVYFFDWDNGTLVRRIDVNAKDVIWSDNGELVMIVNTN 489 Score = 75.7 bits (184), Expect = 7e-14, Method: Composition-based stats. Identities = 34/264 (12%), Positives = 80/264 (30%), Gaps = 46/264 (17%) Query: 196 AELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRIN---DLIDDSEEDSKKLT 252 D VK + F E + + + +W I +E + Sbjct: 7 KTFSNRSDRVKGIDFHPTE----PWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGK 62 Query: 253 LLSNKQYKFQIDDELRVGI------NFEALIMGHDDWISSLQWHESRLQLLAATADTSLM 306 ++ K + D+ R+ + H D+I S+ H ++ +L+ + D ++ Sbjct: 63 FIARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVK 122 Query: 307 VWE----------PDETSGIWVCSLRLGEMSSKGASTATGSSGGFWS------------- 343 +W + +C + S AS + WS Sbjct: 123 LWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTG 182 Query: 344 -------CLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPS 396 ++ + +T + ++W + + G +V+ + P+ Sbjct: 183 QERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVA---TLEGHMSNVSFAVFHPT 239 Query: 397 GEYLLATSLDQTTRLFAPWIYDAS 420 +++ S D T +++ Y Sbjct: 240 LPIIISGSEDGTLKIWNSSTYKVE 263 Score = 59.1 bits (141), Expect = 8e-09, Method: Composition-based stats. Identities = 32/188 (17%), Positives = 68/188 (36%), Gaps = 23/188 (12%) Query: 548 WPEVEKLYGHGFEITCLDISP-DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHS 606 W + GH + C+ +P D AS C + ++++S Sbjct: 130 WALEQTFEGHEHFVMCVAFNPKDPSTFASGC-----LDRTVKVWSLGQSTPNFTLTTGQE 184 Query: 607 LTITRLKFS--KDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPL 664 + + + D ++++ D +W+ + L + H + A + P Sbjct: 185 RGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATL-----EGHMSNVSFAVFHPT 239 Query: 665 EFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIK-HTKAVTAISIHDSMIREKILISVG 723 + ++ S D T+K+W + Y +E ++ + I+ H + K I+ G Sbjct: 240 L--PIIISGSEDGTLKIWN-----SSTYKVEKTLNVGLERSWCIATHPT--GRKNYIASG 290 Query: 724 LENGEIYL 731 +NG L Sbjct: 291 FDNGFTVL 298 Score = 56.1 bits (133), Expect = 7e-08, Method: Composition-based stats. Identities = 35/206 (16%), Positives = 68/206 (33%), Gaps = 25/206 (12%) Query: 583 QNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTF 642 + IR+F+ N E H I + ++LS D LW +N + Sbjct: 75 DDFRIRVFN-YNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNW---ENNW 130 Query: 643 ELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTK 702 L E H + + P + + F + D+TVKVW + ++ L + Sbjct: 131 ALEQTFE-GHEHFVMCVAFNPKD-PSTFASGCLDRTVKVWSL-GQSTPNFTLTT--GQER 185 Query: 703 AVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKFELI---TQLNED----------- 748 V + + + ++ + ++ I ++ Y N Sbjct: 186 GVNYVDYYPLPDKPYMITAS--DDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPII 243 Query: 749 ITPADKITRLRWSHLKRNGKLFLGVG 774 I+ ++ T W+ + L VG Sbjct: 244 ISGSEDGTLKIWNSSTYKVEKTLNVG 269 Score = 52.6 bits (124), Expect = 7e-07, Method: Composition-based stats. Identities = 24/202 (11%), Positives = 65/202 (32%), Gaps = 35/202 (17%) Query: 269 VGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDET-SGIWVCSLRLGEMS 327 + ++ + D + + +H + +L + +W + + + Sbjct: 1 MKLDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRA 60 Query: 328 SKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKD 387 K + R ++ + R++ ++ + Sbjct: 61 GKFIA------------------RKNWIIVGSDDFRIRVFNYNT---GEKVVDFEAHPDY 99 Query: 388 VTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICV-- 445 + IA P+ Y+L+ S D T +L+ ++ W + H + ++CV Sbjct: 100 IRSIAVHPTKPYVLSGSDDLTVKLWN---WE--------NNWALEQTFEGHEHFVMCVAF 148 Query: 446 ETVTDTRFVSGGDEKILRSFDL 467 + F SG ++ ++ + L Sbjct: 149 NPKDPSTFASGCLDRTVKVWSL 170 >6Q8F-A nrPDB Length = 514 Score = 145 bits (366), Expect = 5e-35, Method: Composition-based stats. Identities = 65/366 (17%), Positives = 117/366 (31%), Gaps = 72/366 (19%) Query: 57 GHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYS-----HLQCIQTIQHYSKT--IVA 109 G ++ V C RF PD ++V+ S D +++W FT Q + Sbjct: 213 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMC 272 Query: 110 LSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLA 169 S +++ G DG I +W+ IQ+ + E KG CLS SK Sbjct: 273 FSRDTEMLATGAQDGKIKVWK--IQSGQCLRRFERAHSKG---VTCLSFSK--------- 318 Query: 170 IGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRY 229 + + + G++ + + E GH +V F T + + S S D Sbjct: 319 -DSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATF----TQDGHYIISASSDGT 373 Query: 230 IRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQW 289 +++W ++ + F G D ++S+ Sbjct: 374 VKIWNMKTTE-----------------CSNTF----------KSLGSTAGTDITVNSVIL 406 Query: 290 HESRL-QLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFT 348 + ++++ G V S G+ G F C Sbjct: 407 LPKNPEHFVVCNRSNTVVIMNM---QGQIVRSFSSGKREG----------GDFVCCALS- 452 Query: 349 HERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQT 408 R ++ G+ ++T + ++ KDV IA P + S D Sbjct: 453 -PRGEWIYCVGEDFVLYCFSTVTGKLER---TLTVHEKDVIGIAHHPHQNLIATYSEDGL 508 Query: 409 TRLFAP 414 +L+ P Sbjct: 509 LKLWKP 514 Score = 101 bits (252), Expect = 1e-21, Method: Composition-based stats. Identities = 39/238 (16%), Positives = 83/238 (34%), Gaps = 28/238 (11%) Query: 3 ECITPEAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEV 62 +C+ + T +S +I++ +TI + + +GH + V Sbjct: 298 QCLRRFER-AHSKGVTCLSFSKDSSQILSASFDQTIRI---HGLKSGKTLKEFRGHSSFV 353 Query: 63 TCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYS------KTIVALSALPSL 116 F D +++SAS D VKIW +++ + +++ L P Sbjct: 354 NEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEH 413 Query: 117 ISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVN 176 V T+ I + + ++G + C + +++ +G Sbjct: 414 FVVCNRSNTVVIMNM---QGQIVRSFSSGKREGGDFVCC---ALSPRGEWIYCVG----- 462 Query: 177 VFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWR 234 F+L ++ L HE V +A + L+ + S+D ++LW+ Sbjct: 463 ---EDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQN----LIATYSEDGLLKLWK 513 Score = 99.6 bits (246), Expect = 5e-21, Method: Composition-based stats. Identities = 40/306 (13%), Positives = 100/306 (32%), Gaps = 37/306 (12%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGH--------EAEVTCVRFVPDSDFMVS 76 + +V I +W+ + LK + V C+ F D++ + + Sbjct: 226 DGQYLVTGSVDGFIEVWNF---TTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 282 Query: 77 ASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQND 136 ++D +K+WK L+ + T ++ S S I D TI I Sbjct: 283 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKT 342 Query: 137 -EFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVV 195 + H + + F ++ Y+++ ++ V I + ++ + + Sbjct: 343 LKEFRGHSSFVNEATF---------TQDGHYIIS-ASSDGTVKIWNMKTTECS-NTFKSL 391 Query: 196 AELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIR---INDLIDDSEEDSKKLT 252 G + V S+ + ++ + + ++ + E + Sbjct: 392 GSTAGTDITVNSVILLPKNPEH---FVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVC 448 Query: 253 --LLSNKQYKFQIDDEL------RVGINFEALIMGHDDWISSLQWHESRLQLLAATADTS 304 L ++ + + ++ V E + H+ + + H + + + D Sbjct: 449 CALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGL 508 Query: 305 LMVWEP 310 L +W+P Sbjct: 509 LKLWKP 514 Score = 72.6 bits (176), Expect = 7e-13, Method: Composition-based stats. Identities = 31/143 (21%), Positives = 61/143 (42%), Gaps = 13/143 (9%) Query: 561 ITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKF 620 + C+ S D +++A+ + I+++ ++ ++ HS +T L FSKD Sbjct: 268 VLCMCFSRDTEMLATGAQDGK-----IKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQ 322 Query: 621 LLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVK 680 +LS D+ + E R H+ + +A + G+ ++AS D TVK Sbjct: 323 ILSASFDQTIRIHGLKSGKTLKEFR-----GHSSFVNEA--TFTQDGHYIISASSDGTVK 375 Query: 681 VWRHQ-KEPADDYVLEASIKHTK 702 +W + E ++ + S T Sbjct: 376 IWNMKTTECSNTFKSLGSTAGTD 398 Score = 71.1 bits (172), Expect = 2e-12, Method: Composition-based stats. Identities = 41/193 (21%), Positives = 70/193 (36%), Gaps = 12/193 (6%) Query: 555 YGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKF 614 H +TCL S D I SA IRI ++ +K HS + F Sbjct: 305 RAHSKGVTCLSFSKDSSQILSASFDQT-----IRIHGLKSGKTLK-EFRGHSSFVNEATF 358 Query: 615 SKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTAS 674 ++DG +++S D +W + + + T I ++ + FV + Sbjct: 359 TQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCN 418 Query: 675 RDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSY 734 R TV + Q + + A+S R + + VG E+ +Y +S Sbjct: 419 RSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALS-----PRGEWIYCVG-EDFVLYCFST 472 Query: 735 TLGKFELITQLNE 747 GK E ++E Sbjct: 473 VTGKLERTLTVHE 485 Score = 56.4 bits (134), Expect = 4e-08, Method: Composition-based stats. Identities = 28/175 (16%), Positives = 60/175 (34%), Gaps = 24/175 (13%) Query: 604 FHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDA-DWA 662 + +FS DG++L++ D +W +L+++ + + Sbjct: 213 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMC 272 Query: 663 PLEFGNVFVTASRDKTVKVWRHQ-KEPADDYVLEASIKHTKAVTAISIHDSMIREKILIS 721 + T ++D +KVW+ Q + + H+K VT +S ++S Sbjct: 273 FSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERA----HSKGVTCLSFSKD---SSQILS 325 Query: 722 VGLENGEIYLYSYTLGKFEL-----ITQLNED---------ITPADKITRLRWSH 762 + I ++ GK + +NE I+ + T W+ Sbjct: 326 ASFDQ-TIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNM 379 >2YNP-A nrPDB Length = 604 Score = 144 bits (362), Expect = 2e-34, Method: Composition-based stats. Identities = 40/215 (18%), Positives = 81/215 (37%), Gaps = 25/215 (11%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 I+ I +++ + H + + P +++S S+D VK+W + Sbjct: 70 IIVGSDDFRIRVFNYNTGEK---VVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNW 126 Query: 89 T-DYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQ--NIQNDEFGLAHEFT 145 +++ Q + +H+ + PS + GC D T+ +W + N E Sbjct: 127 ENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERG 186 Query: 146 IKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWV 205 + +YPL +K Y++ ++ + I + + VA LEGH V Sbjct: 187 VNYVDYYPL-------PDKPYMI-TASDDLTIKIWDY-------QTKSCVATLEGHMSNV 231 Query: 206 KSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDL 240 F ++ SGS+D +++W + Sbjct: 232 SFAVFHPTL----PIIISGSEDGTLKIWNSSTYKV 262 Score = 113 bits (282), Expect = 3e-25, Method: Composition-based stats. Identities = 47/355 (13%), Positives = 112/355 (31%), Gaps = 75/355 (21%) Query: 53 ATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSA 112 T V + F P ++++ V++W + ++ IQ + + ++ Sbjct: 7 KTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIAR 66 Query: 113 LPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGG 172 + I VG D I ++ N + +P + V K + G Sbjct: 67 K-NWIIVGSDDFRIRVFNYNTGEK---------VVDFEAHPDYIRSIAVHPTKPYVLSGS 116 Query: 173 TNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRL 232 ++ V + ++ + EGHE +V +AF + SG DR +++ Sbjct: 117 DDLTVKLWNWE------NNWALEQTFEGHEHFVMCVAFNPK---DPSTFASGCLDRTVKV 167 Query: 233 WRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWH-- 290 W L L G + ++ + ++ Sbjct: 168 WS--------------------------------LGQSTPNFTLTTGQERGVNYVDYYPL 195 Query: 291 ESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHE 350 + ++ A+ D ++ +W+ S + G ++ H Sbjct: 196 PDKPYMITASDDLTIKIWDYQTKSCVATLE---------------GHMSNVSFAVF--HP 238 Query: 351 RMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGE--YLLAT 403 + ++ + G+ ++W + + ++ + IA P+G Y+ + Sbjct: 239 TLPIIISGSEDGTLKIWNSSTYKVEK---TLNVGLERSWCIATHPTGRKNYIASG 290 Score = 84.6 bits (207), Expect = 2e-16, Method: Composition-based stats. Identities = 38/192 (19%), Positives = 73/192 (38%), Gaps = 18/192 (9%) Query: 550 EVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTI 609 +V H I + + P + + S + +++++ EN ++ H + Sbjct: 89 KVVDFEAHPDYIRSIAVHPTKPYVLSGS-----DDLTVKLWNWENNWALEQTFEGHEHFV 143 Query: 610 TRLKFSK-DGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGN 668 + F+ D S C DR +W F L R + D+ PL Sbjct: 144 MCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLT----TGQERGVNYVDYYPLPDKP 199 Query: 669 VFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGE 728 +TAS D T+K+W +Q + + H V+ H ++ +I G E+G Sbjct: 200 YMITASDDLTIKIWDYQTK----SCVATLEGHMSNVSFAVFHPTLP----IIISGSEDGT 251 Query: 729 IYLYSYTLGKFE 740 + +++ + K E Sbjct: 252 LKIWNSSTYKVE 263 Score = 83.0 bits (203), Expect = 5e-16, Method: Composition-based stats. Identities = 45/293 (15%), Positives = 96/293 (32%), Gaps = 59/293 (20%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 ++ TI +WD K ATL+GH + V+ F P ++S SED +KIW Sbjct: 201 MITASDDLTIKIWD---YQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNS 257 Query: 89 TDYSHLQCIQTIQHYSKTIVALSA-LPSLISVG-----------------CAD--GTISI 128 + Y + + S I + I+ G D G + + Sbjct: 258 STYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSLDPVGKL-V 316 Query: 129 W------------------RQNIQNDEFGLAHEFTIKKGFFYPLCLSLSK-------VEE 163 W + ++ DE + +P L+ S V + Sbjct: 317 WSGGKNAAASDIFTAVIRGNEEVEQDEPLSLQTKELGSVDVFPQSLAHSPNGRFVTVVGD 376 Query: 164 KKYLL--AIGGTNVNVFIASFILSDSGIEKCRVVAE---LEGHEDWVKSLAFRHQETPGD 218 +Y++ A+ N + ++ E ++ ++++ + ++ Sbjct: 377 GEYVIYTALAWRNKAFGKCQDFVWGPDSNSYALIDETGQIKYYKNFKEVTSWSVPMHSAI 436 Query: 219 YLLCSGS-----QDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDE 266 L SG+ D ++ + L+ + ++K + N + ++ Sbjct: 437 DRLFSGALLGVKSDGFVYFFDWDNGTLVRRIDVNAKDVIWSDNGELVMIVNTN 489 Score = 74.2 bits (180), Expect = 2e-13, Method: Composition-based stats. Identities = 35/264 (13%), Positives = 80/264 (30%), Gaps = 46/264 (17%) Query: 196 AELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRIN---DLIDDSEEDSKKLT 252 D VK + F E + + + LW I +E + Sbjct: 7 KTFSNRSDRVKGIDFHPTE----PWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGK 62 Query: 253 LLSNKQYKFQIDDELRVGI------NFEALIMGHDDWISSLQWHESRLQLLAATADTSLM 306 ++ K + D+ R+ + H D+I S+ H ++ +L+ + D ++ Sbjct: 63 FIARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVK 122 Query: 307 VWE----------PDETSGIWVCSLRLGEMSSKGASTATGSSGGFWS------------- 343 +W + +C + S AS + WS Sbjct: 123 LWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTG 182 Query: 344 -------CLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPS 396 ++ + +T + ++W + + G +V+ + P+ Sbjct: 183 QERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVA---TLEGHMSNVSFAVFHPT 239 Query: 397 GEYLLATSLDQTTRLFAPWIYDAS 420 +++ S D T +++ Y Sbjct: 240 LPIIISGSEDGTLKIWNSSTYKVE 263 Score = 57.6 bits (137), Expect = 2e-08, Method: Composition-based stats. Identities = 32/188 (17%), Positives = 68/188 (36%), Gaps = 23/188 (12%) Query: 548 WPEVEKLYGHGFEITCLDISP-DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHS 606 W + GH + C+ +P D AS C + ++++S Sbjct: 130 WALEQTFEGHEHFVMCVAFNPKDPSTFASGC-----LDRTVKVWSLGQSTPNFTLTTGQE 184 Query: 607 LTITRLKFS--KDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPL 664 + + + D ++++ D +W+ + L + H + A + P Sbjct: 185 RGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATL-----EGHMSNVSFAVFHPT 239 Query: 665 EFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIK-HTKAVTAISIHDSMIREKILISVG 723 + ++ S D T+K+W + Y +E ++ + I+ H + K I+ G Sbjct: 240 L--PIIISGSEDGTLKIWN-----SSTYKVEKTLNVGLERSWCIATHPT--GRKNYIASG 290 Query: 724 LENGEIYL 731 +NG L Sbjct: 291 FDNGFTVL 298 Score = 54.5 bits (129), Expect = 2e-07, Method: Composition-based stats. Identities = 35/206 (16%), Positives = 68/206 (33%), Gaps = 25/206 (12%) Query: 583 QNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTF 642 + IR+F+ N E H I + ++LS D LW +N + Sbjct: 75 DDFRIRVFN-YNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNW---ENNW 130 Query: 643 ELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTK 702 L E H + + P + + F + D+TVKVW + ++ L + Sbjct: 131 ALEQTFE-GHEHFVMCVAFNPKD-PSTFASGCLDRTVKVWSL-GQSTPNFTLTT--GQER 185 Query: 703 AVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKFELI---TQLNED----------- 748 V + + + ++ + ++ I ++ Y N Sbjct: 186 GVNYVDYYPLPDKPYMITAS--DDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPII 243 Query: 749 ITPADKITRLRWSHLKRNGKLFLGVG 774 I+ ++ T W+ + L VG Sbjct: 244 ISGSEDGTLKIWNSSTYKVEKTLNVG 269 Score = 51.8 bits (122), Expect = 1e-06, Method: Composition-based stats. Identities = 24/202 (11%), Positives = 65/202 (32%), Gaps = 35/202 (17%) Query: 269 VGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDET-SGIWVCSLRLGEMS 327 + ++ + D + + +H + +L + +W + + + Sbjct: 1 MKLDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRA 60 Query: 328 SKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKD 387 K + R ++ + R++ ++ + Sbjct: 61 GKFIA------------------RKNWIIVGSDDFRIRVFNYNTG---EKVVDFEAHPDY 99 Query: 388 VTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICV-- 445 + IA P+ Y+L+ S D T +L+ ++ W + H + ++CV Sbjct: 100 IRSIAVHPTKPYVLSGSDDLTVKLWN---WE--------NNWALEQTFEGHEHFVMCVAF 148 Query: 446 ETVTDTRFVSGGDEKILRSFDL 467 + F SG ++ ++ + L Sbjct: 149 NPKDPSTFASGCLDRTVKVWSL 170 >5XYI-g nrPDB Length = 335 Score = 143 bits (359), Expect = 4e-34, Method: Composition-based stats. Identities = 68/307 (22%), Positives = 113/307 (36%), Gaps = 49/307 (15%) Query: 6 TPEAIFIGANK-QTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTC 64 TP IG N + VS ++ T+ LWD K ++ GH+ +V Sbjct: 71 TPFTRLIGHNHFVSDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFL---GHKKDVLG 127 Query: 65 VRFVPDSDFMVSASEDHHVKIWKF--TDYSHLQCIQTIQHYSKTIVALSALPSLISVGCA 122 V F P + ++S D+ VKIW + + LQC + + +A P +I+VGC Sbjct: 128 VTFSPCNRRIISVGRDNQVKIWNILGENKAELQCSSWVTSVACAPMADETSPLVIAVGCW 187 Query: 123 DGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASF 182 DG + IW E L EF G C S+ + K+++ GG++ V + Sbjct: 188 DGKVYIWSI---EKEAKLIKEFKAHDGR----CTSVDFTPDGKWVI-TGGSDRKVVMW-- 237 Query: 183 ILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLID 242 L+++G + A V ++A P +C+ + + +W I ID Sbjct: 238 -LTENGAKTISFTA-----PSPVHAVA----ACPTQAWICAATYEGIA-VWDIGAKQQID 286 Query: 243 DSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATAD 302 + + K + G + L W L + D Sbjct: 287 LVQPNFK----------------------HEGKRNAGRTPDCTCLAWAADGSVLYSGYND 324 Query: 303 TSLMVWE 309 S+ WE Sbjct: 325 GSIRAWE 331 Score = 109 bits (272), Expect = 5e-24, Method: Composition-based stats. Identities = 58/368 (15%), Positives = 111/368 (30%), Gaps = 68/368 (18%) Query: 51 VYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIW--KFTDYSHLQCIQTIQHYSKTI- 107 AT GH A + + + +++VSAS D +W T + ++ + Sbjct: 25 PRATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVS 84 Query: 108 -VALSALPSLISVGCADGTISIWRQNIQN-DEFGLAHEFTIKKGFFYPLCLSLSKVEEKK 165 V+LS S + D T+ +W + + + L H+ + F P Sbjct: 85 DVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSP----------CN 134 Query: 166 YLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYL-LCSG 224 + G + V I + + + +C WV S+A L + G Sbjct: 135 RRIISVGRDNQVKIWNILGENKAELQC---------SSWVTSVACAPMADETSPLVIAVG 185 Query: 225 SQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWI 284 D + +W I + HD Sbjct: 186 CWDGKVYIWSIEKEAKL--------------------------------IKEFKAHDGRC 213 Query: 285 SSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSC 344 +S+ + ++ +D +++W +G S A+ T + W C Sbjct: 214 TSVDFTPDGKWVITGGSDRKVVMW--LTENGAKTISFTAPSPVHAVAACPTQA----WIC 267 Query: 345 LWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATS 404 + + + K + +G T D T +AW+ G L + Sbjct: 268 AATYEGIAVWDIGAKQQIDLVQPNFKHEGKRN-----AGRTPDCTCLAWAADGSVLYSGY 322 Query: 405 LDQTTRLF 412 D + R + Sbjct: 323 NDGSIRAW 330 Score = 76.5 bits (186), Expect = 5e-14, Method: Composition-based stats. Identities = 37/211 (17%), Positives = 74/211 (35%), Gaps = 32/211 (15%) Query: 272 NFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGA 331 A +GH+ I S++ L++A+ D S +VW+ + T W Sbjct: 24 APRATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPF---------- 73 Query: 332 STATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDI 391 T F S + + + LT+ + R+W + G KDV + Sbjct: 74 -TRLIGHNHFVSDVSLSRD-ASHLLTSSWDSTLRLWDLSTR---TTKKLFLGHKKDVLGV 128 Query: 392 AWSPSGEYLLATSLDQTTRLFAPWIYDASGR-KREIATWHEFSRPQIHGYDMICVETVTD 450 +SP +++ D + I++ G K E+ + + C + Sbjct: 129 TFSPCNRRIISVGRDNQVK-----IWNILGENKAELQCSSWVTS-------VACAPMADE 176 Query: 451 T---RFVSGGDEKILRSFDLPKGVAGMLQKF 478 T G + + + + K A ++++F Sbjct: 177 TSPLVIAVGCWDGKVYIWSIEKE-AKLIKEF 206 Score = 71.5 bits (173), Expect = 2e-12, Method: Composition-based stats. Identities = 35/179 (19%), Positives = 71/179 (39%), Gaps = 15/179 (8%) Query: 556 GHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFS 615 GH I ++I + + SA R + + + E W L H+ ++ + S Sbjct: 31 GHNAAIESIEIDNEHNYLVSASRDKSALVWKLN-RTQEQWATPFTRLIGHNHFVSDVSLS 89 Query: 616 KDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASR 675 +D LL+ D LW+ + K H + + ++P ++ R Sbjct: 90 RDASHLLTSSWDSTLRLWDLSTRT-----TKKLFLGHKKDVLGVTFSPCN--RRIISVGR 142 Query: 676 DKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHD-SMIREKILISVGLENGEIYLYS 733 D VK+W E + + VT+++ + ++I+VG +G++Y++S Sbjct: 143 DNQVKIWNILGENKAELQCSS------WVTSVACAPMADETSPLVIAVGCWDGKVYIWS 195 Score = 64.5 bits (155), Expect = 2e-10, Method: Composition-based stats. Identities = 25/128 (19%), Positives = 49/128 (38%), Gaps = 9/128 (7%) Query: 599 KPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWD 658 + H+ I ++ + +L+S RD+ +W+ N + F H + D Sbjct: 26 RATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSD 85 Query: 659 ADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKI 718 + + +T+S D T+++W + H K V ++ R Sbjct: 86 VSLS--RDASHLLTSSWDSTLRLWDLSTRTTKKLF----LGHKKDVLGVTFSPCNRR--- 136 Query: 719 LISVGLEN 726 +ISVG +N Sbjct: 137 IISVGRDN 144 Score = 63.8 bits (153), Expect = 3e-10, Method: Composition-based stats. Identities = 26/159 (16%), Positives = 50/159 (31%), Gaps = 11/159 (6%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 I + +W + K H+ T V F PD ++++ D V +W Sbjct: 182 IAVGCWDGKVYIWSI--EKEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLT 239 Query: 89 TDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGL----AHEF 144 + + T + A + I +G I++W + + HE Sbjct: 240 ENGAKTISF-TAPSPVHAVAACPTQ-AWICAATYEG-IAVWDIGAKQQIDLVQPNFKHEG 296 Query: 145 TIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFI 183 G P C L+ + +L G + ++ Sbjct: 297 KRNAGRT-PDCTCLAWAADGS-VLYSGYNDGSIRAWEVK 333 Score = 63.8 bits (153), Expect = 3e-10, Method: Composition-based stats. Identities = 53/339 (15%), Positives = 115/339 (33%), Gaps = 62/339 (18%) Query: 378 RLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQI 437 R G + I YL++ S D+ + ++ + + + AT F+R Sbjct: 26 RATFVGHNAAIESIEIDNEHNYLVSASRDK-----SALVWKLNRTQEQWAT--PFTRLIG 78 Query: 438 HGYDMICVE-TVTDTRFVSGGDEKILRSFDLPKGVA-----GMLQKFVGIQFEEKSEMPD 491 H + + V + + ++ + LR +DL G + +G+ F P Sbjct: 79 HNHFVSDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFS-----PC 133 Query: 492 SATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPE- 550 + + +G N+ + G NK + ++ + C PM D+ L+ Sbjct: 134 NRRIISVGRDNQVKIWNI-------LGENKAELQCSSWVTSVACAPMADE-TSPLVIAVG 185 Query: 551 -----------------VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTE 593 +++ H T +D +PD K + + + + ++ TE Sbjct: 186 CWDGKVYIWSIEKEAKLIKEFKAHDGRCTSVDFTPDGKWVITGG-----SDRKVVMWLTE 240 Query: 594 NWLE-IKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWE------RNMEDNTFELRF 646 N + I P + + ++ + + A+W+ ++ F+ Sbjct: 241 NGAKTISFTAP---SPVHAVAACPTQAWICAATYEG-IAVWDIGAKQQIDLVQPNFKHEG 296 Query: 647 KNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQ 685 K T WA G+V + D +++ W + Sbjct: 297 KRNAGRTPDCTCLAWAA--DGSVLYSGYNDGSIRAWEVK 333 >6HHQ-h nrPDB Length = 319 Score = 141 bits (356), Expect = 9e-34, Method: Composition-based stats. Identities = 54/306 (17%), Positives = 101/306 (33%), Gaps = 41/306 (13%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNK--GVYATLKGHEAEVTCVRFVPDSDFMVSASEDHH 82 + +++ KT+ W + K + KGH V D + +SAS D Sbjct: 29 QPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDCTLTADGAYALSASWDKT 88 Query: 83 VKIWKFTDYSHLQCIQTIQHYSKTIVALSALP--SLISVGCADGTISIWRQNIQNDEFGL 140 +++W Q + ++++ S+I G D TI +W Q L Sbjct: 89 LRLWDVATGETYQ---RFVGHKSDVMSVDIDKKASMIISGSRDKTIKVWTIKGQCLATLL 145 Query: 141 AHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEG 200 H + + P K ++ + G + V + + ++ A+ G Sbjct: 146 GHNDWVSQVRVVPNE----KADDDSVTIISAGNDKMVKAW-------NLNQFQIEADFIG 194 Query: 201 HEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDL--IDDSEEDSKKLTLLSNKQ 258 H + +L +P L+ S +D I LW + ++++ L N+ Sbjct: 195 HNSNINTLT----ASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQDEVFSLAFSPNRY 250 Query: 259 YKFQ---------------IDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADT 303 + + D+LR F + SL W L A D Sbjct: 251 WLAAATATGIKVFSLDPQYLVDDLR--PEFAGYSKAAEPHAVSLAWSADGQTLFAGYTDN 308 Query: 304 SLMVWE 309 + VW+ Sbjct: 309 VIRVWQ 314 Score = 123 bits (309), Expect = 2e-28, Method: Composition-based stats. Identities = 62/373 (16%), Positives = 124/373 (33%), Gaps = 79/373 (21%) Query: 51 VYATLKGHEAEVTCVRFVPDS-DFMVSASEDHHVKIWKFT--DYSHLQCIQTIQHYSKTI 107 + TL+GH VT + + ++SAS D + WK T D +++ + +S + Sbjct: 9 LRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIV 68 Query: 108 V--ALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKK 165 L+A + D T+ +W T ++ + + +++K Sbjct: 69 QDCTLTADGAYALSASWDKTLRLWDVATGE---------TYQRFVGHKSDVMSVDIDKKA 119 Query: 166 YLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDY--LLCS 223 ++ G + + + + + +A L GH DWV + E D + S Sbjct: 120 SMIISGSRDKTIKVWTIK--------GQCLATLLGHNDWVSQVRVVPNEKADDDSVTIIS 171 Query: 224 GSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDW 283 D+ ++ W + + EA +GH+ Sbjct: 172 AGNDKMVKAWNLNQFQI---------------------------------EADFIGHNSN 198 Query: 284 ISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWS 343 I++L + +A D +M+W +++K A + +S Sbjct: 199 INTLTASPDGTLIASAGKDGEIMLWN----------------LAAKKAMYTLSAQDEVFS 242 Query: 344 CLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATK----DVTDIAWSPSGEY 399 + + TG ++ D R +G +K +AWS G+ Sbjct: 243 LAFS--PNRYWLAAATATGIKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQT 300 Query: 400 LLATSLDQTTRLF 412 L A D R++ Sbjct: 301 LFAGYTDNVIRVW 313 Score = 115 bits (287), Expect = 8e-26, Method: Composition-based stats. Identities = 43/206 (20%), Positives = 73/206 (35%), Gaps = 33/206 (16%) Query: 554 LYGHGFEITCLDISPDQ-KLIASACRSNNVQNAVIRIFSTENWLEIKPALP-----FHSL 607 L GH +T L S Q L+ SA R +I T + K +P HS Sbjct: 13 LEGHNGWVTSLATSAGQPNLLLSASRD----KTLISWKLT--GDDQKFGVPVRSFKGHSH 66 Query: 608 TITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFG 667 + + DG + LS D+ LW+ + ++ H + D Sbjct: 67 IVQDCTLTADGAYALSASWDKTLRLWDVATGE-----TYQRFVGHKSDVMSVDIDKKAS- 120 Query: 668 NVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENG 727 + ++ SRDKT+KVW + + L + H V+ + + + ++ Sbjct: 121 -MIISGSRDKTIKVWTIKGQC-----LATLLGHNDWVSQVRVVPNEKA---------DDD 165 Query: 728 EIYLYSYTLGKFELITQLNEDITPAD 753 + + S K LN+ AD Sbjct: 166 SVTIISAGNDKMVKAWNLNQFQIEAD 191 Score = 101 bits (251), Expect = 1e-21, Method: Composition-based stats. Identities = 53/241 (21%), Positives = 84/241 (34%), Gaps = 30/241 (12%) Query: 8 EAIFIGANKQTQVSDI-HKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVR 66 F+G DI K I++ KTI +W ATL GH V+ VR Sbjct: 100 YQRFVGHKSDVMSVDIDKKASMIISGSRDKTIKVW----TIKGQCLATLLGHNDWVSQVR 155 Query: 67 FVPDSD------FMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVAL--SALPSLIS 118 VP+ ++SA D VK W Q ++ I L S +LI+ Sbjct: 156 VVPNEKADDDSVTIISAGNDKMVKAWNLN---QFQIEADFIGHNSNINTLTASPDGTLIA 212 Query: 119 VGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVF 178 DG I +W + + L+ + + SL+ + +L A T + VF Sbjct: 213 SAGKDGEIMLWNLAAKKAMYTLSAQDEV---------FSLAFSPNRYWLAAATATGIKVF 263 Query: 179 IASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRIN 238 + E G+ + A + L +G D IR+W++ Sbjct: 264 SLDPQYLVDDLRP-----EFAGYSKAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQVMTA 318 Query: 239 D 239 + Sbjct: 319 N 319 Score = 91.1 bits (224), Expect = 2e-18, Method: Composition-based stats. Identities = 57/382 (14%), Positives = 128/382 (33%), Gaps = 88/382 (23%) Query: 274 EALIMGHDDWISSLQWHESRL-QLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGAS 332 + GH+ W++SL + LL+A+ D +L+ W+ + S KG S Sbjct: 10 RGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQK----FGVPVRSFKGHS 65 Query: 333 TATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIA 392 T + + L+ + R+W + G DV + Sbjct: 66 -------HIVQDCTLTADGA-YALSASWDKTLRLWDVATGETYQR---FVGHKSDVMSVD 114 Query: 393 WSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETV---- 448 +++ S D+T + ++ G+ H + V V Sbjct: 115 IDKKASMIISGSRDKTIK-----VWTIKGQ-----CLATLL---GHNDWVSQVRVVPNEK 161 Query: 449 ---TDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAG 505 +S G++K++++++L QF+ +++ +G ++ Sbjct: 162 ADDDSVTIISAGNDKMVKAWNLN-------------QFQIEADF--------IGHNSNIN 200 Query: 506 EDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGH----GFEI 561 A+ D +L+ + ++ +LW K + E+ Sbjct: 201 TLTASPD-----------------GTLIASAGKDGEI---MLWNLAAKKAMYTLSAQDEV 240 Query: 562 TCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSL----TITRLKFSKD 617 L SP++ +A+A + ++ + + +++P +S L +S D Sbjct: 241 FSLAFSPNRYWLAAATATGIKVFSLDPQYLVD---DLRPEFAGYSKAAEPHAVSLAWSAD 297 Query: 618 GKFLLSVCRDRKWALWERNMED 639 G+ L + D +W+ + Sbjct: 298 GQTLFAGYTDNVIRVWQVMTAN 319 Score = 56.4 bits (134), Expect = 5e-08, Method: Composition-based stats. Identities = 66/382 (17%), Positives = 125/382 (32%), Gaps = 78/382 (20%) Query: 372 NIICDQRLGISGATKDVTDIAWSPSG-EYLLATSLDQTTRLFAPWIYDASGRKREIATWH 430 N + R + G VT +A S LL+ S D+T + +G ++ Sbjct: 4 NEVLVLRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTL-----ISWKLTGDDQKFGVPV 58 Query: 431 EFSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMP 490 + H C T +S +K LR +D+ G Q+FVG KS++ Sbjct: 59 RSFKGHSHIVQ-DCTLTADGAYALSASWDKTLRLWDVATGET--YQRFVG----HKSDV- 110 Query: 491 DSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPE 550 + DI S++ + ++ + + Sbjct: 111 -------------------------------MSVDIDKKASMIISGSRDKTIKVWTIKGQ 139 Query: 551 -VEKLYGHGFEITCLDISPDQK------LIASACRSNNVQNAVIRIFSTENWLEIKPALP 603 + L GH ++ + + P++K I SA V+ + F E Sbjct: 140 CLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQIEAD------FI 193 Query: 604 FHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAP 663 H+ I L S DG + S +D + LW + + L ++E ++ ++P Sbjct: 194 GHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQDE------VFSLAFSP 247 Query: 664 LEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVG 723 + TA+ +KV+ + D + ++KA + Sbjct: 248 NRYWLAAATAT---GIKVFSLDPQYLVDDLRPEFAGYSKA----------AEPHAVSLAW 294 Query: 724 LENGEIYLYSYTLGKFELITQL 745 +G+ YT + Q+ Sbjct: 295 SADGQTLFAGYT-DNVIRVWQV 315 Score = 54.1 bits (128), Expect = 3e-07, Method: Composition-based stats. Identities = 33/200 (16%), Positives = 65/200 (32%), Gaps = 18/200 (9%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 V GH + ++ D SA +R++ E H + Sbjct: 58 VRSFKGHSHIVQDCTLTADGAYALSASWDKT-----LRLWDVATG-ETYQRFVGHKSDVM 111 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVF 670 + K ++S RD+ +W L N+ + + A + Sbjct: 112 SVDIDKKASMIISGSRDKTIKVWTIK-GQCLATLLGHNDWVSQVRVVPNEKADDDSVT-I 169 Query: 671 VTASRDKTVKVWRHQKEPADDYVLEASI-KHTKAVTAISIHDSMIREKILISVGLENGEI 729 ++A DK VK W + + +EA H + ++ LI+ ++GEI Sbjct: 170 ISAGNDKMVKAWNL-----NQFQIEADFIGHNSNINTLTASPDGT----LIASAGKDGEI 220 Query: 730 YLYSYTLGKFELITQLNEDI 749 L++ K +++ Sbjct: 221 MLWNLAAKKAMYTLSAQDEV 240 >4V7E-Bg nrPDB Length = 380 Score = 141 bits (355), Expect = 1e-33, Method: Composition-based stats. Identities = 62/394 (15%), Positives = 135/394 (34%), Gaps = 73/394 (18%) Query: 31 AFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTD 90 + G+T ++P + TL+GH +V + + P+ +++VSAS+D + +W Sbjct: 41 SKAQGRTAVSFNP---TDLVCCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALT 97 Query: 91 YSHLQCIQTIQHYSKTIVALSALPSL--ISVGCADGTISIWRQNIQND---EFGLAHEFT 145 Q I+ + ++ + P+ ++ G D SI+ + Q D ++ T Sbjct: 98 S---QKTHAIKLHCPWVMECAFAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLT 154 Query: 146 IKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAEL-----EG 200 KG+ S V +++ L G + + + + ++ G Sbjct: 155 GHKGY----ASSCQYVPDQETRLITGSGDQTCVLW-------DVTTGQRISIFGSEFPSG 203 Query: 201 HEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYK 260 H V SL+ + + SGS D +RLW + Sbjct: 204 HTADVLSLSIN---SLNANMFISGSCDTTVRLWDL------------------------- 235 Query: 261 FQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCS 320 R+ GH+ I+S+++ + + D + +++ + V + Sbjct: 236 -------RITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYN 288 Query: 321 LRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLG 380 R + + + + + F+ F G +W T + Sbjct: 289 -REPDRN--------DNELPIVTSVAFSISGRLLFAGYS-NGDCYVWDTLLAEMVLNLGT 338 Query: 381 IS-GATKDVTDIAWSPSGEYLLATSLDQTTRLFA 413 + ++ + S G L S D+ +++A Sbjct: 339 LQNSHEGRISCLGLSSDGSALCTGSWDKNLKIWA 372 Score = 105 bits (262), Expect = 6e-23, Method: Composition-based stats. Identities = 37/222 (16%), Positives = 82/222 (36%), Gaps = 16/222 (7%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNKGVYATL--KGHEAEVTCVRFVP-DSDFMVSASEDH 81 + +++ +T LWD ++ + GH A+V + +++ +S S D Sbjct: 169 QETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDT 228 Query: 82 HVKIWKFTDYSHLQCIQTIQHYSKTIVALSA--LPSLISVGCADGTISIWRQNIQNDEFG 139 V++W + ++T + I ++ G DGT ++ + Sbjct: 229 TVRLWDLR--ITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQV 286 Query: 140 LAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELE 199 E P+ S++ + L A G +N + ++ +L++ + + Sbjct: 287 YNREPDRNDNE-LPIVTSVAFSISGRLLFA-GYSNGDCYVWDTLLAEMVLNLGTLQNS-- 342 Query: 200 GHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLI 241 HE + L LC+GS D+ +++W + I Sbjct: 343 -HEGRISCLGLS----SDGSALCTGSWDKNLKIWAFSGHRKI 379 Score = 94.6 bits (233), Expect = 2e-19, Method: Composition-based stats. Identities = 50/331 (15%), Positives = 101/331 (30%), Gaps = 76/331 (22%) Query: 194 VVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDL---IDDSEEDSKK 250 L+GH V SL + ++ + S SQD + +W + I + Sbjct: 58 CCRTLQGHSGKVYSLDWTPEKN----WIVSASQDGRLIVWNALTSQKTHAIKLHCPWVME 113 Query: 251 LTLLSNKQ-------------YKFQIDDELRVGINFEALIMGHDDWISSLQWHESR-LQL 296 N Q + + + ++ GH + SS Q+ + +L Sbjct: 114 CAFAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRL 173 Query: 297 LAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFL 356 + + D + ++W+ I + G+ +G + S L + F+ Sbjct: 174 ITGSGDQTCVLWDVTTGQRISIF----------GSEFPSGHTADVLS-LSINSLNANMFI 222 Query: 357 TNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLF---- 412 + + R+W + + G D+ + + P G+ S D T RLF Sbjct: 223 SGSCDTTVRLWDLRITSRAVRTYH--GHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRT 280 Query: 413 --APWIYD-------------------ASGR-------KREIATWHEF---------SRP 435 +Y+ SGR + W + Sbjct: 281 GHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQ 340 Query: 436 QIHGYDMICVE-TVTDTRFVSGGDEKILRSF 465 H + C+ + + +G +K L+ + Sbjct: 341 NSHEGRISCLGLSSDGSALCTGSWDKNLKIW 371 Score = 73.8 bits (179), Expect = 3e-13, Method: Composition-based stats. Identities = 64/363 (17%), Positives = 117/363 (32%), Gaps = 65/363 (17%) Query: 333 TATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIA 392 T G SG +S W ++ ++ + G +W + + I V + A Sbjct: 61 TLQGHSGKVYSLDWT--PEKNWIVSASQDGRLIVWNALTS---QKTHAIKLHCPWVMECA 115 Query: 393 WSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSR--PQIHGYDMICVETVT- 449 ++P+G+ + LD A I++ S + SR GY C Sbjct: 116 FAPNGQSVACGGLDS-----ACSIFNLSSQADRDGNM-PVSRVLTGHKGYASSCQYVPDQ 169 Query: 450 DTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDA 509 +TR ++G ++ +D+ G Q+ SE P T VL LS Sbjct: 170 ETRLITGSGDQTCVLWDVTTG-----QRISIF----GSEFPSGHTADVLSLS-------- 212 Query: 510 NEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQR----HLLWPEVEKLYGHGFEITCLD 565 I + + D R + V +GH +I + Sbjct: 213 ----------------INSLNANMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINSVK 256 Query: 566 ISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSL------TITRLKFSKDGK 619 PD + + + R+F +++ +T + FS G+ Sbjct: 257 FFPDGQRFGTGS-----DDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVTSVAFSISGR 311 Query: 620 FLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTV 679 L + + +W+ + + L + H I + G+ T S DK + Sbjct: 312 LLFAGYSNGDCYVWDTLLAEMVLNL-GTLQNSHEGRI--SCLGLSSDGSALCTGSWDKNL 368 Query: 680 KVW 682 K+W Sbjct: 369 KIW 371 Score = 71.5 bits (173), Expect = 1e-12, Method: Composition-based stats. Identities = 64/364 (17%), Positives = 124/364 (34%), Gaps = 57/364 (15%) Query: 275 ALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTA 334 + GH + SL W + +++A+ D L+VW + L + A Sbjct: 60 RTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWVM----ECA 115 Query: 335 TGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWS 394 +G +C F L++ M ++ ++G + + Sbjct: 116 FAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRV---------LTGHKGYASSCQYV 166 Query: 395 PSGE-YLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMIC--VETVTDT 451 P E L+ S DQT L +D + +R EF P H D++ + ++ Sbjct: 167 PDQETRLITGSGDQTCVL-----WDVTTGQRISIFGSEF--PSGHTADVLSLSINSLNAN 219 Query: 452 RFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSE--MPDSATVPVLGLSNKAGEDDA 509 F+SG + +R +DL + + ++ + G + + S PD G G DD Sbjct: 220 MFISGSCDTTVRLWDL-RITSRAVRTYHGHEGDINSVKFFPD-------GQRFGTGSDDG 271 Query: 510 NEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPD 569 + G++ L + P + + + +T + S Sbjct: 272 TCRLFDMRTGHQ--------LQVYNREPDRNDNELPI--------------VTSVAFSIS 309 Query: 570 QKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRK 629 +L+ + + + + E L + H I+ L S DG L + D+ Sbjct: 310 GRLLFAGYSNGDCYVWDTLL--AEMVLNLGTLQNSHEGRISCLGLSSDGSALCTGSWDKN 367 Query: 630 WALW 633 +W Sbjct: 368 LKIW 371 Score = 56.1 bits (133), Expect = 7e-08, Method: Composition-based stats. Identities = 29/177 (16%), Positives = 65/177 (36%), Gaps = 12/177 (6%) Query: 552 EKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITR 611 L GH ++ LD +P++ I SA + + +++ + A+ H + Sbjct: 60 RTLQGHSGKVYSLDWTPEKNWIVSASQDGRLI-----VWNALT-SQKTHAIKLHCPWVME 113 Query: 612 LKFSKDGKFLLSVCRDRKWALWE--RNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNV 669 F+ +G+ + D +++ + + + H + P + Sbjct: 114 CAFAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETR- 172 Query: 670 FVTASRDKTVKVWRH-QKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLE 725 +T S D+T +W + + E HT V ++SI+ + + IS + Sbjct: 173 LITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINS--LNANMFISGSCD 227 Score = 55.3 bits (131), Expect = 1e-07, Method: Composition-based stats. Identities = 30/208 (14%), Positives = 58/208 (27%), Gaps = 14/208 (6%) Query: 538 MEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLE 597 + Q R P L GH + PDQ+ + + T Sbjct: 137 LSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITG---SGDQTCVLWDVTTGQRI 193 Query: 598 IKPALP---FHSLTITRLKFSK-DGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHT 653 H+ + L + + +S D LW+ + + + + Sbjct: 194 SIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRI-TSRAVRTYHGHEGDI 252 Query: 654 RIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSM 713 + G F T S D T +++ + ++ I + Sbjct: 253 NSVK-----FFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNREPDRN-DNELPIVTSVAF 306 Query: 714 IREKILISVGLENGEIYLYSYTLGKFEL 741 L+ G NG+ Y++ L + L Sbjct: 307 SISGRLLFAGYSNGDCYVWDTLLAEMVL 334 Score = 47.6 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 17/79 (21%), Positives = 34/79 (43%), Gaps = 1/79 (1%) Query: 17 QTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLK-GHEAEVTCVRFVPDSDFMV 75 T V+ + + A + +WD + TL+ HE ++C+ D + Sbjct: 301 VTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQNSHEGRISCLGLSSDGSALC 360 Query: 76 SASEDHHVKIWKFTDYSHL 94 + S D ++KIW F+ + + Sbjct: 361 TGSWDKNLKIWAFSGHRKI 379 Score = 44.1 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 31/188 (16%), Positives = 60/188 (31%), Gaps = 16/188 (8%) Query: 601 ALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDAD 660 L HS + L ++ + +++S +D + +W + K H + + Sbjct: 61 TLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQ-----KTHAIKLHCPWVMECA 115 Query: 661 WAPLEFGNVFVTASRDKTVKVWRHQKEPADD---YVLEASIKHTKAVTAISIHDSMIREK 717 +AP G D ++ + D V H ++ Sbjct: 116 FAP--NGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRL 173 Query: 718 ILISVGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSD 777 I S + L+ T G+ I+ + L S N +F+ GS D Sbjct: 174 ITGSG---DQTCVLWDVTTGQ--RISIFGSEFPSGHTADVLSLSINSLNANMFIS-GSCD 227 Query: 778 LSTRIYSL 785 + R++ L Sbjct: 228 TTVRLWDL 235 >5Z56-q nrPDB Length = 504 Score = 141 bits (354), Expect = 2e-33, Method: Composition-based stats. Identities = 56/294 (19%), Positives = 104/294 (35%), Gaps = 34/294 (11%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVK 84 KI+ GA K + ++D +++ + ATLKGH +VT V F P D + SAS D ++ Sbjct: 233 DTNKILTGGADKNVVVFD---KSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIR 289 Query: 85 IWKFTDYSHLQCIQTIQHYSKTIVALSAL--PSLISVGCADGTISIWRQNIQNDEFGLAH 142 IW + C+Q ++ + + LS + D W + + Sbjct: 290 IWSVPNA---SCVQVVRAHESAVTGLSLHATGDYLLSSSDDQ---YWAFS----DIQTGR 339 Query: 143 EFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHE 202 T L+ ++ + G + + I + VA GH Sbjct: 340 VLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTN-------VANFPGHS 392 Query: 203 DWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLID----DSEEDSKKLTLLSNKQ 258 + S+AF Y L + + D ++LW +R D+ + K L + Sbjct: 393 GPITSIAFS----ENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGT 448 Query: 259 YKFQIDDELRVGI----NFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVW 308 Y ++++ I H + + + + + D SL + Sbjct: 449 YLALGGTDVQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFY 502 Score = 91.1 bits (224), Expect = 2e-18, Method: Composition-based stats. Identities = 48/272 (17%), Positives = 86/272 (31%), Gaps = 64/272 (23%) Query: 141 AHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEG 200 +H L L L + K L GG + NV + +++A L+G Sbjct: 212 SHVGLHSASIPGILALDLCPSDTNKIL--TGGADKNVVV-------FDKSSEQILATLKG 262 Query: 201 HEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYK 260 H V S+ F + L+ S S D IR+W + + Sbjct: 263 HTKKVTSVVFHPSQD----LVFSASPDATIRIWSVPNASCVQ------------------ 300 Query: 261 FQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCS 320 ++ H+ ++ L H + LL+++ D + + + Sbjct: 301 ---------------VVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVT 345 Query: 321 LRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLG 380 S +C F H F T ++W K+ Sbjct: 346 DETSGCSL--------------TCAQF-HPDGLIFGTGTMDSQIKIWDLKERTNVA---N 387 Query: 381 ISGATKDVTDIAWSPSGEYLLATSLDQTTRLF 412 G + +T IA+S +G YL + D + +L+ Sbjct: 388 FPGHSGPITSIAFSENGYYLATAADDSSVKLW 419 Score = 81.5 bits (199), Expect = 1e-15, Method: Composition-based stats. Identities = 45/316 (14%), Positives = 104/316 (32%), Gaps = 54/316 (17%) Query: 110 LSALPSLISVGCADGTISIWRQNIQNDEFGL-AHEFTIKKGFFYPLCLSLSKVEEKKYLL 168 + + I G AD + ++ ++ + L H + F+P + L+ Sbjct: 230 CPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPS----------QDLV 279 Query: 169 AIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDR 228 + + I S + V + HE V L+ L S S D+ Sbjct: 280 FSASPDATIRIWS-------VPNASCVQVVRAHESAVTGLSLH----ATGDYLLSSSDDQ 328 Query: 229 YIRLWRIRINDLIDDSEEDSKKLTLLSNKQY-------KFQIDDELRVGINFEALIM--- 278 Y I+ ++ +++ +L + + +D ++++ E + Sbjct: 329 YWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANF 388 Query: 279 -GHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGS 337 GH I+S+ + E+ L A D+S+ +W+ K T Sbjct: 389 PGHSGPITSIAFSENGYYLATAADDSSVKLWDL---------------RKLKNFKTLQLD 433 Query: 338 SGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSG 397 + L F + G + I+ + + T +A+ Sbjct: 434 NNFEVKSLIFDQSGT-YLALGGTDVQIYICKQWTEIL-----HFTEHSGLTTGVAFGHHA 487 Query: 398 EYLLATSLDQTTRLFA 413 +++ +T +D++ + ++ Sbjct: 488 KFIASTGMDRSLKFYS 503 Score = 74.9 bits (182), Expect = 1e-13, Method: Composition-based stats. Identities = 27/148 (18%), Positives = 52/148 (35%), Gaps = 4/148 (2%) Query: 24 HKVKKIV-AFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHH 82 H I I +WD E N A GH +T + F + ++ +A++D Sbjct: 359 HPDGLIFGTGTMDSQIKIWDLKERTN---VANFPGHSGPITSIAFSENGYYLATAADDSS 415 Query: 83 VKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAH 142 VK+W + + +Q ++ + + +++G D I I +Q + F Sbjct: 416 VKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTEHS 475 Query: 143 EFTIKKGFFYPLCLSLSKVEEKKYLLAI 170 T F + S ++ Sbjct: 476 GLTTGVAFGHHAKFIASTGMDRSLKFYS 503 Score = 69.5 bits (168), Expect = 6e-12, Method: Composition-based stats. Identities = 36/179 (20%), Positives = 68/179 (37%), Gaps = 19/179 (10%) Query: 554 LYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLK 613 L GH ++T + P Q L+ SA +A IRI+S N ++ + H +T L Sbjct: 260 LKGHTKKVTSVVFHPSQDLVFSAS-----PDATIRIWSVPNASCVQV-VRAHESAVTGLS 313 Query: 614 FSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTA 673 G +LLS D+ WA + T G +F T Sbjct: 314 LHATGDYLLSSSDDQYWAFSDIQTGR-----VLTKVTDETSGCSLTCAQFHPDGLIFGTG 368 Query: 674 SRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLY 732 + D +K+W ++ + H+ +T+I+ ++ ++ ++ + L+ Sbjct: 369 TMDSQIKIWDLKERTN----VANFPGHSGPITSIAFSENGYY----LATAADDSSVKLW 419 Score = 50.7 bits (119), Expect = 3e-06, Method: Composition-based stats. Identities = 32/174 (18%), Positives = 60/174 (34%), Gaps = 22/174 (12%) Query: 560 EITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGK 619 +TC PD + + + I+I+ + P HS IT + FS++G Sbjct: 352 SLTCAQFHPDGLIFGTGTMDSQ-----IKIWDLKERT-NVANFPGHSGPITSIAFSENGY 405 Query: 620 FLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTV 679 +L + D LW+ N L+ N +I+D + G D + Sbjct: 406 YLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFD------QSGTYLALGGTDVQI 459 Query: 680 KVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYS 733 + + +H+ T ++ K + S G++ + YS Sbjct: 460 YI------CKQWTEILHFTEHSGLTTGVAFG---HHAKFIASTGMDRS-LKFYS 503 Score = 49.9 bits (117), Expect = 5e-06, Method: Composition-based stats. Identities = 19/127 (14%), Positives = 39/127 (30%), Gaps = 12/127 (9%) Query: 9 AIFIGAN-KQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEA-EVTCVR 66 A F G + T ++ + ++ LWD + N + TL+ EV + Sbjct: 386 ANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKN---FKTLQLDNNFEVKSLI 442 Query: 67 FVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSA--LPSLISVGCADG 124 F ++ D + I I +S ++ I+ D Sbjct: 443 FDQSGTYLALGGTDVQIYI-----CKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDR 497 Query: 125 TISIWRQ 131 ++ + Sbjct: 498 SLKFYSL 504 Score = 44.1 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 36/230 (15%), Positives = 69/230 (30%), Gaps = 37/230 (16%) Query: 561 ITCLDISP-DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGK 619 I LD+ P D I + NV + ++ +I L H+ +T + F Sbjct: 224 ILALDLCPSDTNKILTGGADKNV------VVFDKSSEQILATLKGHTKKVTSVVFHPSQD 277 Query: 620 FLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTV 679 + S D +W +R + G+ +++S D Sbjct: 278 LVFSASPDATIRIWSVPNASCVQVVRAHESAV-------TGLSLHATGDYLLSSSDD--- 327 Query: 680 KVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKF 739 Y + I+ + +T ++ S L + + T+ Sbjct: 328 -----------QYWAFSDIQTGRVLTKVTDETSG---CSLTCAQFHPDGLIFGTGTMDSQ 373 Query: 740 ELITQLNEDIT----PADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYSL 785 I L E P + + NG +L + D S +++ L Sbjct: 374 IKIWDLKERTNVANFPGHSGPITSIAFSE-NG-YYLATAADDSSVKLWDL 421 >4V6W-Ag nrPDB Length = 318 Score = 140 bits (353), Expect = 2e-33, Method: Composition-based stats. Identities = 52/338 (15%), Positives = 103/338 (30%), Gaps = 43/338 (12%) Query: 1 MVECITPEAIFIGANKQTQVSDIH--KVKKIVAFGAGKTIALWDPIEPNNKG---VYATL 55 M E + IG N + I++ KT+ +W + L Sbjct: 1 MSETLQLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRL 60 Query: 56 KGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSA--L 113 GH ++ V D ++ +S S D +++W + + ++K +++++ Sbjct: 61 YGHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTT---RRFEGHTKDVLSVAFSAD 117 Query: 114 PSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGT 173 I G D TI +W + C+ S +++ G Sbjct: 118 NRQIVSGSRDKTIKLWNT-----LAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCG-- 170 Query: 174 NVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW 233 + + C++ GH ++ ++ P L SG +D LW Sbjct: 171 ------WDRTVKVWNLANCKLKNNHHGHNGYLNTVTVS----PDGSLCTSGGKDSKALLW 220 Query: 234 RIRI--NDLIDDSEEDSKKLTLLSNKQY-------KFQIDDELRVGINFEAL-------I 277 + N + + L N+ + +I D E Sbjct: 221 DLNDGKNLYTLEHNDIINALCFSPNRYWLCVAYGPSIKIWDLACKKTVEELRPEVVSPTS 280 Query: 278 MGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSG 315 SL W L A +D ++ VW+ ++ Sbjct: 281 KADQPQCLSLAWSTDGQTLFAGYSDNTIRVWQVSVSAH 318 Score = 129 bits (324), Expect = 4e-30, Method: Composition-based stats. Identities = 60/378 (15%), Positives = 130/378 (34%), Gaps = 71/378 (18%) Query: 46 PNNKGVYATLKGHEAEVTCVRFVP-DSDFMVSASEDHHVKIWKFTD------YSHLQCIQ 98 + TL GH VT + P D D ++SAS D + +WK T + + Sbjct: 2 SETLQLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLY 61 Query: 99 TIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSL 158 H+ +V LS+ + G D T+ +W E K LS+ Sbjct: 62 GHSHFISDVV-LSSDGNYALSGSWDQTLRLWDLAAGK--TTRRFEGHTKDV------LSV 112 Query: 159 SKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGD 218 + + + +++ G + + + + + +C+ + +GH DWV + F + + Sbjct: 113 AFSADNRQIVS-GSRDKTIKLWNT------LAECKFTIQEDGHTDWVSCVRFSPNHS--N 163 Query: 219 YLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIM 278 ++ S DR +++W + L N + Sbjct: 164 PIIVSCGWDRTVKVWNLAN--------------CKLKNNHH------------------- 190 Query: 279 GHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSS 338 GH+ +++++ + D+ ++W+ ++ ++ + + Sbjct: 191 GHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLEHNDIINALCFSP------ 244 Query: 339 GGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGE 398 +W C+ + + L KT + + ++ +AWS G+ Sbjct: 245 NRYWLCVAYGPSIKIWDLACKKT----VEELRPEVVSPTS---KADQPQCLSLAWSTDGQ 297 Query: 399 YLLATSLDQTTRLFAPWI 416 L A D T R++ + Sbjct: 298 TLFAGYSDNTIRVWQVSV 315 Score = 108 bits (270), Expect = 7e-24, Method: Composition-based stats. Identities = 58/378 (15%), Positives = 126/378 (33%), Gaps = 78/378 (20%) Query: 274 EALIMGHDDWISSLQWHESRL-QLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGAS 332 ++GH+ W++ + + +++A+ D +L+VW+ + + G S Sbjct: 8 RGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDE---DTNYGYPQKRLYGHS 64 Query: 333 TATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIA 392 F S + + + ++ L+ + R+W + G TKDV +A Sbjct: 65 -------HFISDVVLSSDG-NYALSGSWDQTLRLWDLAAGKTTRR---FEGHTKDVLSVA 113 Query: 393 WSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVE---TVT 449 +S +++ S D+T +L+ H + CV + Sbjct: 114 FSADNRQIVSGSRDKTIKLW----------NTLAECKFTIQEDG-HTDWVSCVRFSPNHS 162 Query: 450 DTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDA 509 + VS G ++ ++ ++L + Sbjct: 163 NPIIVSCGWDRTVKVWNLA--------------------------------------NCK 184 Query: 510 NEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWP--EVEKLYG--HGFEITCLD 565 +++ G T ++ SL + + LLW + + LY H I L Sbjct: 185 LKNNHHGHNGYLNTVTVSPDGSLCTSGGKDS---KALLWDLNDGKNLYTLEHNDIINALC 241 Query: 566 ISPDQKLIASACRSNNVQNAVIRIFSTENWLE---IKPALPFHSLTITRLKFSKDGKFLL 622 SP++ + A +++ + T L + P L +S DG+ L Sbjct: 242 FSPNRYWLCVA-YGPSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTLF 300 Query: 623 SVCRDRKWALWERNMEDN 640 + D +W+ ++ + Sbjct: 301 AGYSDNTIRVWQVSVSAH 318 Score = 96.1 bits (237), Expect = 5e-20, Method: Composition-based stats. Identities = 38/170 (22%), Positives = 63/170 (37%), Gaps = 11/170 (6%) Query: 554 LYGHGFEITCLDISP-DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRL 612 L GH +T + +P D I SA R + + N+ + L HS I+ + Sbjct: 11 LIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDV 70 Query: 613 KFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVT 672 S DG + LS D+ LW+ + + HT+ + ++ V+ Sbjct: 71 VLSSDGNYALSGSWDQTLRLWDLAAGK-----TTRRFEGHTKDVLSVAFSA--DNRQIVS 123 Query: 673 ASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISV 722 SRDKT+K+W E HT V+ + + I+ Sbjct: 124 GSRDKTIKLWNTLAECK---FTIQEDGHTDWVSCVRFSPNHSNPIIVSCG 170 Score = 71.5 bits (173), Expect = 1e-12, Method: Composition-based stats. Identities = 64/375 (17%), Positives = 131/375 (34%), Gaps = 70/375 (18%) Query: 376 DQRLGISGATKDVTDIAWSP-SGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSR 434 R + G VT IA +P + +++ S D+T ++ R + + R Sbjct: 6 QLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLT------RDEDTNYGYPQKR 59 Query: 435 PQIHGYDMI-CVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSA 493 H + + V + +SG ++ LR +DL G ++F G Sbjct: 60 LYGHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAG--KTTRRFEG------------H 105 Query: 494 TVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEK 553 T VL ++ A ++ + G +T + + L+ + ED Sbjct: 106 TKDVLSVAFSA------DNRQIVSGSRDKTIKLWNTLAECKFTIQED------------- 146 Query: 554 LYGHGFEITCLDISPDQK--LIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITR 611 GH ++C+ SP+ +I S + +++++ N ++K H+ + Sbjct: 147 --GHTDWVSCVRFSPNHSNPIIVSCGW-----DRTVKVWNLAN-CKLKNNHHGHNGYLNT 198 Query: 612 LKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFV 671 + S DG S +D K LW+ N N + L H II ++P + Sbjct: 199 VTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLE------HNDIINALCFSPNRYWLCVA 252 Query: 672 TASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYL 731 ++K+W + + + +S + + L +G+ Sbjct: 253 YGP---SIKIWDLACKKTVEELRPEV---------VSPTSKADQPQCLSLAWSTDGQTLF 300 Query: 732 YSYTLGKFELITQLN 746 Y+ + Q++ Sbjct: 301 AGYS-DNTIRVWQVS 314 >6GMH-W nrPDB Length = 305 Score = 138 bits (348), Expect = 7e-33, Method: Composition-based stats. Identities = 49/295 (16%), Positives = 109/295 (36%), Gaps = 31/295 (10%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVK 84 + +V + +W + +L+GH+ V V S+S D H++ Sbjct: 31 NSETVVTGSLDDLVKVW-KWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIR 89 Query: 85 IWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEF 144 +W + ++ I + T+ A S ++ G G ++I+ E+ L Sbjct: 90 LWDLENGKQIKSIDAGPVDAWTL-AFSPDSQYLATGTHVGKVNIFGVESGKKEYSL---- 144 Query: 145 TIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDW 204 LS++ + KY LA G + I++ I +++ LEGH Sbjct: 145 ----DTRGKFILSIAYSPDGKY-LASGAIDG-------IINIFDIATGKLLHTLEGHAMP 192 Query: 205 VKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLID---DSEEDSKKLTLLSNKQYKF 261 ++SL F P LL + S D YI+++ ++ +L + + + Sbjct: 193 IRSLTFS----PDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFV 248 Query: 262 QIDDELRVGINFEALIM------GHDDWISSLQWHESRLQLLAATADTSLMVWEP 310 + V + H D + ++++ + ++++ D + +++ Sbjct: 249 SSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDC 303 Score = 73.0 bits (177), Expect = 4e-13, Method: Composition-based stats. Identities = 51/317 (16%), Positives = 106/317 (33%), Gaps = 51/317 (16%) Query: 162 EEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLL 221 +E + G + V + + ++ LEGH+ V S+ H + Sbjct: 29 KENSETVVTGSLDDLVKVWKWRDERLDLQ-----WSLEGHQLGVVSVDISHTL----PIA 79 Query: 222 CSGSQDRYIRLWRIRINDLI---DDSEEDSKKLTLLSNKQYKFQIDDELRVGI------N 272 S S D +IRLW + I D D+ L + QY +V I Sbjct: 80 ASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGK 139 Query: 273 FEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGAS 332 E + +I S+ + L + D + +++ + Sbjct: 140 KEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLE------------ 187 Query: 333 TATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIA 392 G + S + ++ +T G +++ + + +SG V ++A Sbjct: 188 ---GHAMPIRSLTFSPDSQL--LVTASDDGYIKIYDVQHANLAG---TLSGHASWVLNVA 239 Query: 393 WSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVE-TVTDT 451 + P + ++ ++ + ++D R H F H + V+ + Sbjct: 240 FCPDDTHFVS-----SSSDKSVKVWDVGTR----TCVHTFFD---HQDQVWGVKYNGNGS 287 Query: 452 RFVSGGDEKILRSFDLP 468 + VS GD++ + +D P Sbjct: 288 KIVSVGDDQEIHIYDCP 304 Score = 54.9 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 31/178 (17%), Positives = 61/178 (34%), Gaps = 23/178 (12%) Query: 540 DQLQRHLLWPE------VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTE 593 L H+ + ++ + + L SPD + +A+ + IF E Sbjct: 82 SSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGK-----VNIFGVE 136 Query: 594 NWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHT 653 + + + +L I + +S DGK+L S D +++ + H Sbjct: 137 SG-KKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLL-----HTLEGHA 190 Query: 654 RIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHD 711 I ++P + VTAS D +K++ Q + H V ++ Sbjct: 191 MPIRSLTFSP--DSQLLVTASDDGYIKIYDVQH----ANLAGTLSGHASWVLNVAFCP 242 Score = 48.4 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 38/206 (18%), Positives = 71/206 (34%), Gaps = 27/206 (13%) Query: 554 LYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLK 613 L GH + +DIS + AS+ +A IR++ EN +IK T L Sbjct: 60 LEGHQLGVVSVDISHTLPIAASSS-----LDAHIRLWDLENGKQIKSIDAGPVDAWT-LA 113 Query: 614 FSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTA 673 FS D ++L + K ++ + L + + I ++P G + Sbjct: 114 FSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRG-----KFILSIAYSP--DGKYLASG 166 Query: 674 SRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYS 733 + D + ++ A +L H + +++ + L+ ++G I +Y Sbjct: 167 AIDGIINIFDI----ATGKLLHTLEGHAMPIRSLTFSP----DSQLLVTASDDGYIKIYD 218 Query: 734 YTLGKFE------LITQLNEDITPAD 753 LN P D Sbjct: 219 VQHANLAGTLSGHASWVLNVAFCPDD 244 Score = 46.4 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 35/196 (17%), Positives = 58/196 (29%), Gaps = 33/196 (16%) Query: 279 GHDDWISSLQW----HESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTA 334 HDD I S+ W E+ ++ + D + VW+ L S Sbjct: 14 AHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWK--WRDERLDLQWSLEGHQLGVVSVD 71 Query: 335 TGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWS 394 + + + L NGK I D +A+S Sbjct: 72 ISHTLPIAASSSLDAHIRLWDLENGKQIK----------------SIDAGPVDAWTLAFS 115 Query: 395 PSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFV 454 P +YL + +F SG+K E+S + + + Sbjct: 116 PDSQYLATGTHVGKVNIFGVE----SGKK-------EYSLDTRGKFILSIAYSPDGKYLA 164 Query: 455 SGGDEKILRSFDLPKG 470 SG + I+ FD+ G Sbjct: 165 SGAIDGIINIFDIATG 180 Score = 43.3 bits (100), Expect = 4e-04, Method: Composition-based stats. Identities = 41/179 (22%), Positives = 73/179 (40%), Gaps = 21/179 (11%) Query: 554 LYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLK 613 L G I + SPD K +AS + +I IF + L H++ I L Sbjct: 144 LDTRGKFILSIAYSPDGKYLASGA-----IDGIINIFDIATGKLLH-TLEGHAMPIRSLT 197 Query: 614 FSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTA 673 FS D + L++ D +++ + L H + + + P + FV++ Sbjct: 198 FSPDSQLLVTASDDGYIKIYDVQHANLAGTL-----SGHASWVLNVAFCPDDT--HFVSS 250 Query: 674 SRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLY 732 S DK+VKVW + H V + + + + ++SVG ++ EI++Y Sbjct: 251 SSDKSVKVWDV----GTRTCVHTFFDHQDQVWGVKYNGNGSK---IVSVG-DDQEIHIY 301 Score = 39.9 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 51/317 (16%), Positives = 104/317 (32%), Gaps = 44/317 (13%) Query: 383 GATKDVTDIAWSPSGEY----LLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIH 438 + +AW + + ++ SLD + ++ + ++ E + + Sbjct: 14 AHDDAIWSVAWGTNKKENSETVVTGSLDDLVK-----VWKWRDERLDLQWSLEGHQLGVV 68 Query: 439 GYDMICVETVTDTRFVSGGDEKILRSFDLPKGV------AGMLQKFVGIQFEEKSEMPDS 492 D+ + T S + +R +DL G AG + + + F PDS Sbjct: 69 SVDI----SHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWT-LAFS-----PDS 118 Query: 493 ---ATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWP 549 AT +G N G + ++ + G P D + Sbjct: 119 QYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIA 178 Query: 550 E---VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHS 606 + L GH I L SPD +L+ +A + I+I+ ++ + L H+ Sbjct: 179 TGKLLHTLEGHAMPIRSLTFSPDSQLLVTAS-----DDGYIKIYDVQH-ANLAGTLSGHA 232 Query: 607 LTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEF 666 + + F D +S D+ +W+ H +W + Sbjct: 233 SWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFF-----DHQDQVWGVKY--NGN 285 Query: 667 GNVFVTASRDKTVKVWR 683 G+ V+ D+ + ++ Sbjct: 286 GSKIVSVGDDQEIHIYD 302 Score = 37.2 bits (84), Expect = 0.026, Method: Composition-based stats. Identities = 31/139 (22%), Positives = 49/139 (35%), Gaps = 17/139 (12%) Query: 639 DNTFELRFKNEKPHTRIIWDADWA--PLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEA 696 N + + FK E+ H IW W E VT S D VKVW+ + E D + + Sbjct: 2 TNQYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLD--LQWS 59 Query: 697 SIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKFELITQLNEDITPADKIT 756 H V ++ I ++ + + + I L+ GK I D Sbjct: 60 LEGHQLGVVSVDISHTLP----IAASSSLDAHIRLWDLENGK---------QIKSIDAGP 106 Query: 757 RLRWSHLKRNGKLFLGVGS 775 W+ +L G+ Sbjct: 107 VDAWTLAFSPDSQYLATGT 125 Score = 37.2 bits (84), Expect = 0.032, Method: Composition-based stats. Identities = 14/79 (17%), Positives = 30/79 (37%), Gaps = 4/79 (5%) Query: 10 IFIGANK-QTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFV 68 G V+ V+ + K++ +WD + T H+ +V V++ Sbjct: 227 TLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDV---GTRTCVHTFFDHQDQVWGVKYN 283 Query: 69 PDSDFMVSASEDHHVKIWK 87 + +VS +D + I+ Sbjct: 284 GNGSKIVSVGDDQEIHIYD 302 Score = 31.8 bits (70), Expect = 1.3, Method: Composition-based stats. Identities = 16/131 (12%), Positives = 38/131 (29%), Gaps = 7/131 (5%) Query: 555 YGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKF 614 H I + ++K + + ++ + V + L+++ +L H L + + Sbjct: 13 QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDI 72 Query: 615 SKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTAS 674 S S D LW+ + + A T + Sbjct: 73 SHTLPIAASSSLDAHIRLWDLENGKQI-------KSIDAGPVDAWTLAFSPDSQYLATGT 125 Query: 675 RDKTVKVWRHQ 685 V ++ + Sbjct: 126 HVGKVNIFGVE 136 >4LG8-A nrPDB Length = 354 Score = 136 bits (343), Expect = 2e-32, Method: Composition-based stats. Identities = 57/294 (19%), Positives = 105/294 (35%), Gaps = 34/294 (11%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVK 84 KI+ GA K + ++D +++ + ATLKGH +VT V F P D + SAS D ++ Sbjct: 83 DTNKILTGGADKNVVVFD---KSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIR 139 Query: 85 IWKFTDYSHLQCIQTIQHYSKTIVALSAL--PSLISVGCADGTISIWRQNIQNDEFGLAH 142 IW + C+Q ++ + + LS + D W + + Sbjct: 140 IWSVPNA---SCVQVVRAHESAVTGLSLHATGDYLLSSSDDQ---YWAFS----DIQTGR 189 Query: 143 EFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHE 202 T L+ ++ + G + + I + VA GH Sbjct: 190 VLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTN-------VANFPGHS 242 Query: 203 DWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRI----NDLIDDSEEDSKKLTLLSNKQ 258 + S+AF Y L + + D ++LW +R L D+ + K L + Sbjct: 243 GPITSIAFS----ENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGT 298 Query: 259 YKFQIDDELRVGI----NFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVW 308 Y ++++ I H + + + + + D SL + Sbjct: 299 YLALGGTDVQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFY 352 Score = 88.0 bits (216), Expect = 1e-17, Method: Composition-based stats. Identities = 48/272 (17%), Positives = 86/272 (31%), Gaps = 64/272 (23%) Query: 141 AHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEG 200 +H L L L + K L GG + NV + +++A L+G Sbjct: 62 SHVGLHSASIPGILALDLCPSDTNKIL--TGGADKNVVV-------FDKSSEQILATLKG 112 Query: 201 HEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYK 260 H V S+ F + L+ S S D IR+W + + Sbjct: 113 HTKKVTSVVFHPSQD----LVFSASPDATIRIWSVPNASCVQ------------------ 150 Query: 261 FQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCS 320 ++ H+ ++ L H + LL+++ D + + + Sbjct: 151 ---------------VVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVT 195 Query: 321 LRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLG 380 S +C F H F T ++W K+ Sbjct: 196 DETSGCSL--------------TCAQF-HPDGLIFGTGTMDSQIKIWDLKERTNVA---N 237 Query: 381 ISGATKDVTDIAWSPSGEYLLATSLDQTTRLF 412 G + +T IA+S +G YL + D + +L+ Sbjct: 238 FPGHSGPITSIAFSENGYYLATAADDSSVKLW 269 Score = 84.6 bits (207), Expect = 2e-16, Method: Composition-based stats. Identities = 45/229 (19%), Positives = 76/229 (33%), Gaps = 30/229 (13%) Query: 9 AIFIGANKQTQVSDIHKVKKIV-AFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRF 67 A G K+ H + +V + TI +W N ++ HE+ VT + Sbjct: 108 ATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVP---NASCVQVVRAHESAVTGLSL 164 Query: 68 VPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTI--VALSALPSLIS--VGCAD 123 D+++S+S+D + W F+D + + + + P + G D Sbjct: 165 HATGDYLLSSSDD---QYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMD 221 Query: 124 GTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFI 183 I IW + + F G + S E Y LA + +V + Sbjct: 222 SQIKIWDLKERTN----VANFPGHSGPITSIAFS-----ENGYYLATAADDSSVKLWDLR 272 Query: 184 LSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRL 232 + ++ E VKSL F T L G D I + Sbjct: 273 -KLKNFKTLQLDNNFE-----VKSLIFDQSGT----YLALGGTDVQIYI 311 Score = 78.8 bits (192), Expect = 8e-15, Method: Composition-based stats. Identities = 45/316 (14%), Positives = 104/316 (32%), Gaps = 54/316 (17%) Query: 110 LSALPSLISVGCADGTISIWRQNIQNDEFGL-AHEFTIKKGFFYPLCLSLSKVEEKKYLL 168 + + I G AD + ++ ++ + L H + F+P + L+ Sbjct: 80 CPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPS----------QDLV 129 Query: 169 AIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDR 228 + + I S + V + HE V L+ L S S D+ Sbjct: 130 FSASPDATIRIWS-------VPNASCVQVVRAHESAVTGLSLH----ATGDYLLSSSDDQ 178 Query: 229 YIRLWRIRINDLIDDSEEDSKKLTLLSNKQY-------KFQIDDELRVGINFEALIM--- 278 Y I+ ++ +++ +L + + +D ++++ E + Sbjct: 179 YWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANF 238 Query: 279 -GHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGS 337 GH I+S+ + E+ L A D+S+ +W+ K T Sbjct: 239 PGHSGPITSIAFSENGYYLATAADDSSVKLWDL---------------RKLKNFKTLQLD 283 Query: 338 SGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSG 397 + L F + G + I+ + + T +A+ Sbjct: 284 NNFEVKSLIFDQSGT-YLALGGTDVQIYICKQWTEIL-----HFTEHSGLTTGVAFGHHA 337 Query: 398 EYLLATSLDQTTRLFA 413 +++ +T +D++ + ++ Sbjct: 338 KFIASTGMDRSLKFYS 353 Score = 73.4 bits (178), Expect = 4e-13, Method: Composition-based stats. Identities = 25/140 (17%), Positives = 50/140 (35%), Gaps = 3/140 (2%) Query: 31 AFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTD 90 I +WD E N A GH +T + F + ++ +A++D VK+W Sbjct: 217 TGTMDSQIKIWDLKERTN---VANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRK 273 Query: 91 YSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGF 150 + + +Q ++ + + +++G D I I +Q + F T F Sbjct: 274 LKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTEHSGLTTGVAF 333 Query: 151 FYPLCLSLSKVEEKKYLLAI 170 + S ++ Sbjct: 334 GHHAKFIASTGMDRSLKFYS 353 Score = 67.2 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 36/179 (20%), Positives = 68/179 (37%), Gaps = 19/179 (10%) Query: 554 LYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLK 613 L GH ++T + P Q L+ SA +A IRI+S N ++ + H +T L Sbjct: 110 LKGHTKKVTSVVFHPSQDLVFSAS-----PDATIRIWSVPNASCVQV-VRAHESAVTGLS 163 Query: 614 FSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTA 673 G +LLS D+ WA + T G +F T Sbjct: 164 LHATGDYLLSSSDDQYWAFSDIQTGR-----VLTKVTDETSGCSLTCAQFHPDGLIFGTG 218 Query: 674 SRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLY 732 + D +K+W ++ + H+ +T+I+ ++ ++ ++ + L+ Sbjct: 219 TMDSQIKIWDLKERTN----VANFPGHSGPITSIAFSENGYY----LATAADDSSVKLW 269 Score = 48.7 bits (114), Expect = 9e-06, Method: Composition-based stats. Identities = 32/174 (18%), Positives = 60/174 (34%), Gaps = 22/174 (12%) Query: 560 EITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGK 619 +TC PD + + + I+I+ + P HS IT + FS++G Sbjct: 202 SLTCAQFHPDGLIFGTGTMDSQ-----IKIWDLKERT-NVANFPGHSGPITSIAFSENGY 255 Query: 620 FLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTV 679 +L + D LW+ N L+ N +I+D + G D + Sbjct: 256 YLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFD------QSGTYLALGGTDVQI 309 Query: 680 KVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYS 733 + + +H+ T ++ K + S G++ + YS Sbjct: 310 YI------CKQWTEILHFTEHSGLTTGVAFGH---HAKFIASTGMDRS-LKFYS 353 Score = 48.4 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 19/127 (14%), Positives = 39/127 (30%), Gaps = 12/127 (9%) Query: 9 AIFIGAN-KQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEA-EVTCVR 66 A F G + T ++ + ++ LWD + N + TL+ EV + Sbjct: 236 ANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKN---FKTLQLDNNFEVKSLI 292 Query: 67 FVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSA--LPSLISVGCADG 124 F ++ D + I I +S ++ I+ D Sbjct: 293 FDQSGTYLALGGTDVQIYI-----CKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDR 347 Query: 125 TISIWRQ 131 ++ + Sbjct: 348 SLKFYSL 354 Score = 42.2 bits (97), Expect = 8e-04, Method: Composition-based stats. Identities = 36/230 (15%), Positives = 69/230 (30%), Gaps = 37/230 (16%) Query: 561 ITCLDISP-DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGK 619 I LD+ P D I + NV + ++ +I L H+ +T + F Sbjct: 74 ILALDLCPSDTNKILTGGADKNV------VVFDKSSEQILATLKGHTKKVTSVVFHPSQD 127 Query: 620 FLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTV 679 + S D +W +R + G+ +++S D Sbjct: 128 LVFSASPDATIRIWSVPNASCVQVVRAHESAV-------TGLSLHATGDYLLSSSDD--- 177 Query: 680 KVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKF 739 Y + I+ + +T ++ S L + + T+ Sbjct: 178 -----------QYWAFSDIQTGRVLTKVTDETSG---CSLTCAQFHPDGLIFGTGTMDSQ 223 Query: 740 ELITQLNEDIT----PADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYSL 785 I L E P + + NG +L + D S +++ L Sbjct: 224 IKIWDLKERTNVANFPGHSGPITSIAFSE-NG-YYLATAADDSSVKLWDL 271 >6N9G-C nrPDB Length = 353 Score = 136 bits (343), Expect = 2e-32, Method: Composition-based stats. Identities = 63/368 (17%), Positives = 121/368 (32%), Gaps = 70/368 (19%) Query: 49 KGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIV 108 TLKGH +V C+ + D +VS+S+D V +W + + ++ Sbjct: 53 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKE---HAVTMPCTWVM 109 Query: 109 ALSALPSL--ISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKY 166 A + PS I+ G D S++ +E A + ++ Y S + + + Sbjct: 110 ACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFT-NSDMQI 168 Query: 167 LLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQ 226 L A G ++ +E +++ GH V L ET SG Sbjct: 169 LTASGDGTCALW---------DVESGQLLQSFHGHGADVLCLDLAPSET--GNTFVSGGC 217 Query: 227 DRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISS 286 D+ +W +R + E H+ ++S Sbjct: 218 DKKAMVWDMRSGQCVQAFET---------------------------------HESDVNS 244 Query: 287 LQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLW 346 ++++ S + + D + +++ + + S S S + Sbjct: 245 VRYYPSGDAFASGSDDATCRLYDLRADREVAIYS--------------KESIIFGASSVD 290 Query: 347 FTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGIS-GATKDVTDIAWSPSGEYLLATSL 405 F+ F + +W + R+ I G V+ + SP G + S Sbjct: 291 FSLSGRLLFA-GYNDYTINVWDV----LKGSRVSILFGHENRVSTLRVSPDGTAFCSGSW 345 Query: 406 DQTTRLFA 413 D T R++A Sbjct: 346 DHTLRVWA 353 Score = 112 bits (280), Expect = 5e-25, Method: Composition-based stats. Identities = 48/229 (20%), Positives = 84/229 (36%), Gaps = 28/229 (12%) Query: 9 AIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFV 68 ++ + N + S + +I+ T ALWD + + + GH A+V C+ Sbjct: 148 SVAMHTNYLSACSFTNSDMQILTASGDGTCALWDV---ESGQLLQSFHGHGADVLCLDLA 204 Query: 69 P--DSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSL--ISVGCADG 124 P + VS D +W QC+Q + + + ++ PS + G D Sbjct: 205 PSETGNTFVSGGCDKKAMVWDMRSG---QCVQAFETHESDVNSVRYYPSGDAFASGSDDA 261 Query: 125 TISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFIL 184 T ++ + + E F + S LL G + + + Sbjct: 262 TCRLYDLRADREVAIYSKE----SIIFGASSVDFSLSG---RLLFAGYND-------YTI 307 Query: 185 SDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW 233 + + K V+ L GHE+ V +L P CSGS D +R+W Sbjct: 308 NVWDVLKGSRVSILFGHENRVSTLRVS----PDGTAFCSGSWDHTLRVW 352 Score = 83.4 bits (204), Expect = 4e-16, Method: Composition-based stats. Identities = 56/381 (14%), Positives = 118/381 (30%), Gaps = 90/381 (23%) Query: 94 LQCIQTIQHYSKTIVALSA--LPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFF 151 ++ +T++ + ++ + I DG + +W F E + Sbjct: 53 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWD------SFTTNKEHAVTMPCT 106 Query: 152 YPLCLSLSKVEEKKYLLAIGGTNVN--VFIASFILSDSGIEKCRVVAELEGHEDWVKSLA 209 + + + + +A GG + V+ +F +++ K + VA H +++ + + Sbjct: 107 WVMACAYAPSG---CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAM---HTNYLSACS 160 Query: 210 FRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRV 269 F T D + + S D LW D E + + +D Sbjct: 161 F----TNSDMQILTASGDGTCALW---------DVESGQLLQSFHGHGADVLCLD----- 202 Query: 270 GINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSK 329 L E+ ++ D MVW+ + Sbjct: 203 -----------------LAPSETGNTFVSGGCDKKAMVWDMRSGQCVQ------------ 233 Query: 330 GASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVT 389 A + + + + + D F + + R++ + D+ + I + Sbjct: 234 ----AFETHESDVNSVRY-YPSGDAFASGSDDATCRLYDLR----ADREVAIYSKESIIF 284 Query: 390 ---DIAWSPSGEYLLATSLDQTTRLFAPWIYDA-SGRKREIATWHEFSRPQIHGYDMICV 445 + +S SG L A D T ++D G + I HE + + Sbjct: 285 GASSVDFSLSGRLLFAGYNDYTIN-----VWDVLKGSRVSILFGHE--------NRVSTL 331 Query: 446 E-TVTDTRFVSGGDEKILRSF 465 + T F SG + LR + Sbjct: 332 RVSPDGTAFCSGSWDHTLRVW 352 Score = 59.5 bits (142), Expect = 6e-09, Method: Composition-based stats. Identities = 53/337 (15%), Positives = 115/337 (34%), Gaps = 59/337 (17%) Query: 271 INFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKG 330 + + GH + + + W + + ++++++ D ++VW+ T+ ++ Sbjct: 53 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCT------ 106 Query: 331 ASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNI---ICDQRLGISGATKD 387 W G ++ + + ++ ++ T Sbjct: 107 -----------WVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNY 155 Query: 388 VTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVE- 446 ++ +++ S +L S D T L+ ++ + HG D++C++ Sbjct: 156 LSACSFTNSDMQILTASGDGTCALW------------DVESGQLLQSFHGHGADVLCLDL 203 Query: 447 --TVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQ-FEEKSEMPDSATVPVLGLSNK 503 + T FVSGG +K +D+ G +Q FE +S G + Sbjct: 204 APSETGNTFVSGGCDKKAMVWDMRSGQC--------VQAFETHESDVNSVRYYPSGDAFA 255 Query: 504 AGEDDAN------EDDEEEEGGNKE-------TPDITDPLSLLECPPMEDQLQRHLLWPE 550 +G DDA D E +KE + D + LL + + + Sbjct: 256 SGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKG 315 Query: 551 VEK--LYGHGFEITCLDISPDQKLIASACRSNNVQNA 585 L+GH ++ L +SPD S + ++ Sbjct: 316 SRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352 Score = 56.4 bits (134), Expect = 4e-08, Method: Composition-based stats. Identities = 60/363 (16%), Positives = 109/363 (30%), Gaps = 61/363 (16%) Query: 323 LGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGIS 382 LG+ K T G W +R +++ + G +W + + + + Sbjct: 48 LGQFVMKTRRTLKGHGNKVLCMDWCKDKRR--IVSSSQDGKVIVWDS-FTTNKEHAVTMP 104 Query: 383 GATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDAS---GRKREIATWHEFSRPQIHG 439 V A++PSG + LD ++ P +D + K++ H Sbjct: 105 --CTWVMACAYAPSGCAIACGGLDNKCSVY-PLTFDKNENMAAKKKSVAMHT-------N 154 Query: 440 YDMICVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLG 499 Y C T +D + ++ + +D+ G +LQ F G Sbjct: 155 YLSACSFTNSDMQILTASGDGTCALWDVESG--QLLQSFHG------------------- 193 Query: 500 LSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGF 559 G D D E GN D +++ +Q H Sbjct: 194 ----HGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQA---------FETHES 240 Query: 560 EITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGK 619 ++ + P AS + +R + + S + FS G+ Sbjct: 241 DVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASS----VDFSLSGR 296 Query: 620 FLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTV 679 L + D +W+ R H + +P G F + S D T+ Sbjct: 297 LLFAGYNDYTINVWDVLKGS-----RVSILFGHENRVSTLRVSP--DGTAFCSGSWDHTL 349 Query: 680 KVW 682 +VW Sbjct: 350 RVW 352 Score = 51.8 bits (122), Expect = 1e-06, Method: Composition-based stats. Identities = 44/255 (17%), Positives = 75/255 (29%), Gaps = 57/255 (22%) Query: 552 EKLYGHGFEITCLDISPDQKLIASACRSNNVQNA---------VIRIFST---------- 592 L GHG ++ C+D D++ I S+ + V + + T Sbjct: 57 RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 116 Query: 593 -----------------------ENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRK 629 EN K ++ H+ ++ F+ +L+ D Sbjct: 117 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT 176 Query: 630 WALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQ-KEP 688 ALW+ H + D AP E GN FV+ DK VW + + Sbjct: 177 CALWDVESGQLLQSFH-----GHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQC 231 Query: 689 ADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKFELITQLNED 748 + H V ++ + S + G ++ LY + I Sbjct: 232 VQAFET-----HESDVNSVRYYPSGDA----FASGSDDATCRLYDLRADREVAIYSKESI 282 Query: 749 ITPADKITRLRWSHL 763 I A + L Sbjct: 283 IFGASSVDFSLSGRL 297 >4L9O-A nrPDB Length = 349 Score = 135 bits (340), Expect = 6e-32, Method: Composition-based stats. Identities = 53/287 (18%), Positives = 106/287 (36%), Gaps = 27/287 (9%) Query: 26 VKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPD--SDFMVSASEDHHV 83 +++ + KTI +++ I+ N+ + TL GHE V V + + S S D V Sbjct: 81 GRRLATCSSDKTIKIFE-IDGENQRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGKV 139 Query: 84 KIWKFTDYSHLQCIQTIQHYSKTIVALSALP----SLISVGCADGTISI--WRQNIQNDE 137 IWK + + + ++ ++S P ++ +DG ISI ++ + Sbjct: 140 LIWKEDNGVW-NKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISIVEFKDGGALEP 198 Query: 138 FGL-AHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVA 196 + H + + P+ L + GG + V I + D + Sbjct: 199 IVIQGHAIGVNAASWAPISL-----PDNTRRFVSGGCDNLVKIWRY---DDAAKTFIEEE 250 Query: 197 ELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSN 256 +GH DWV+ +A+ Y + + SQDR + +W D + + + L+ Sbjct: 251 AFQGHSDWVRDVAWSPSRLSKSY-IATASQDRTVLIW-------TKDGKSNKWEKQPLTK 302 Query: 257 KQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADT 303 +++ I G D+ ++ + + A D Sbjct: 303 EKFPDVCWRASWSLSGNVLAISGGDNKVTLWKENIQGKWESAGEVDQ 349 Score = 98.0 bits (242), Expect = 1e-20, Method: Composition-based stats. Identities = 44/326 (13%), Positives = 102/326 (31%), Gaps = 66/326 (20%) Query: 58 HEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSAL---- 113 H+ + + + S D +KI++ D + + ++T+ + + ++ Sbjct: 68 HDDLIHDAVLDYYGRRLATCSSDKTIKIFEI-DGENQRLVETLIGHEGPVWQVAWAHPKF 126 Query: 114 PSLISVGCADGTISIWRQNIQ---NDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAI 170 +++ DG + IW+++ H+ ++ + P E +L Sbjct: 127 GVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPH--------EYGPVLLC 178 Query: 171 GGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGD-YLLCSGSQDRY 229 ++ + I F + ++GH V + ++ P + SG D Sbjct: 179 ASSDGKISIVEFKDGGALEP-----IVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNL 233 Query: 230 IRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQW 289 +++WR D T + + + GH DW+ + W Sbjct: 234 VKIWRY-----------DDAAKTFIEEEAF------------------QGHSDWVRDVAW 264 Query: 290 HESRL---QLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLW 346 SRL + A+ D ++++W D S W + Sbjct: 265 SPSRLSKSYIATASQDRTVLIWTKDGKSNKW-----------EKQPLTKEKFPDVCWRAS 313 Query: 347 FTHERMDFFLTNGKTGSWRMWATKDN 372 ++ ++ G +W Sbjct: 314 WSLSGNVLAISGG-DNKVTLWKENIQ 338 Score = 73.4 bits (178), Expect = 4e-13, Method: Composition-based stats. Identities = 48/304 (15%), Positives = 102/304 (33%), Gaps = 46/304 (15%) Query: 146 IKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWV 205 + G + + + ++ LA ++ + I E R+V L GHE V Sbjct: 62 VTIGNAHDDLIHDAVLDYYGRRLATCSSDKTIKIFEI-----DGENQRLVETLIGHEGPV 116 Query: 206 KSLAFRHQETPGDYLLCSGSQDRYIRLWR-------------IRINDLIDDSEEDSKK-- 250 +A+ H + +L S S D + +W+ + + S + Sbjct: 117 WQVAWAHPKF--GVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGP 174 Query: 251 LTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHE-----SRLQLLAATADTSL 305 + L ++ K I + G +I GH +++ W + + ++ D + Sbjct: 175 VLLCASSDGKISIVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLV 234 Query: 306 MVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMD--FFLTNGKTGS 363 +W D+ + ++ A + + ++ R+ + T + + Sbjct: 235 KIWRYDDAAKTFIEE------------EAFQGHSDWVRDVAWSPSRLSKSYIATASQDRT 282 Query: 364 WRMW--ATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWI---YD 418 +W K N Q L +WS SG L + D L+ I ++ Sbjct: 283 VLIWTKDGKSNKWEKQPLTKEKFPDVCWRASWSLSGNVLAISGGDNKVTLWKENIQGKWE 342 Query: 419 ASGR 422 ++G Sbjct: 343 SAGE 346 Score = 60.7 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 38/217 (17%), Positives = 73/217 (33%), Gaps = 9/217 (4%) Query: 551 VEKLYGHGFEITCLD-ISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPAL-PFHSLT 608 VE L GH + + P +I ++C + + I+ +N + K A H + Sbjct: 106 VETLIGHEGPVWQVAWAHPKFGVILASCSY----DGKVLIWKEDNGVWNKVAEHSVHQAS 161 Query: 609 ITRLKFSKD--GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEF 666 + + ++ G LL D K ++ E + + A + + Sbjct: 162 VNSVSWAPHEYGPVLLCASSDGKISIVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDN 221 Query: 667 GNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLEN 726 FV+ D VK+WR+ EA H+ V ++ S + + + + + Sbjct: 222 TRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDR 281 Query: 727 GEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHL 763 + L ++ P D R WS Sbjct: 282 TVLIWTKDGKSNKWEKQPLTKEKFP-DVCWRASWSLS 317 Score = 58.0 bits (138), Expect = 2e-08, Method: Composition-based stats. Identities = 38/197 (19%), Positives = 65/197 (32%), Gaps = 36/197 (18%) Query: 279 GHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSS 338 HDD I +L ++D ++ ++E D + V +L G Sbjct: 67 AHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETL-------------IGHE 113 Query: 339 GGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPS-- 396 G W W + + G +W +DN + ++ S V ++W+P Sbjct: 114 GPVWQVAWAHPKFGVILASCSYDGKVLIWK-EDNGVWNKVAEHSVHQASVNSVSWAPHEY 172 Query: 397 GEYLLATSLDQTTRL--------FAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETV 448 G LL S D + P + A+W S P Sbjct: 173 GPVLLCASSDGKISIVEFKDGGALEPIVIQGHAIGVNAASWAPISLPD------------ 220 Query: 449 TDTRFVSGGDEKILRSF 465 RFVSGG + +++ + Sbjct: 221 NTRRFVSGGCDNLVKIW 237 Score = 48.7 bits (114), Expect = 9e-06, Method: Composition-based stats. Identities = 22/137 (16%), Positives = 56/137 (40%), Gaps = 8/137 (5%) Query: 553 KLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLE---IKPALPFHSLTI 609 + GH + +P + + + +++I+ ++ + + A HS + Sbjct: 200 VIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSDWV 259 Query: 610 TRLKFSKD---GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEF 666 + +S ++ + +DR +W ++ + N +E + ++ + W A W+ Sbjct: 260 RDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVCWRASWS--LS 317 Query: 667 GNVFVTASRDKTVKVWR 683 GNV + D V +W+ Sbjct: 318 GNVLAISGGDNKVTLWK 334 Score = 34.9 bits (78), Expect = 0.12, Method: Composition-based stats. Identities = 10/67 (14%), Positives = 21/67 (31%), Gaps = 2/67 (2%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNK--GVYATLKGHEAEVTCVRFVPDSDFMVSASEDHH 82 I +T+ +W +NK T + + + + + D+ Sbjct: 270 SKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVCWRASWSLSGNVLAISGGDNK 329 Query: 83 VKIWKFT 89 V +WK Sbjct: 330 VTLWKEN 336 Score = 32.9 bits (73), Expect = 0.49, Method: Composition-based stats. Identities = 18/91 (19%), Positives = 31/91 (34%), Gaps = 6/91 (6%) Query: 550 EVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIF----STENWLEIKPALPFH 605 E E GH + + SP ++ + + Q+ + I+ + W + Sbjct: 248 EEEAFQGHSDWVRDVAWSP--SRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKF 305 Query: 606 SLTITRLKFSKDGKFLLSVCRDRKWALWERN 636 R +S G L D K LW+ N Sbjct: 306 PDVCWRASWSLSGNVLAISGGDNKVTLWKEN 336 Score = 32.6 bits (72), Expect = 0.73, Method: Composition-based stats. Identities = 12/43 (27%), Positives = 20/43 (46%), Gaps = 2/43 (4%) Query: 667 GNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISI 709 G T S DKT+K++ E + ++E I H V ++ Sbjct: 81 GRRLATCSSDKTIKIFEIDGE--NQRLVETLIGHEGPVWQVAW 121 >6J6H-n nrPDB Length = 455 Score = 135 bits (340), Expect = 6e-32, Method: Composition-based stats. Identities = 50/285 (17%), Positives = 101/285 (35%), Gaps = 37/285 (12%) Query: 48 NKGVYATLKGHEAEVTCVRFVP-DSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKT 106 K V GH T ++F+P ++S DH +KIW F Y +C++ Q ++K Sbjct: 151 PKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF--YHDYECLRDFQGHNKP 208 Query: 107 IVALSALPSL--ISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEK 164 I AL D ++ IW + L T P + Sbjct: 209 IKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNST-------PADVESRPTNPH 261 Query: 165 KYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSG 224 ++++ + + + D E +V + H + +L + P S Sbjct: 262 EFIVGLSNSKI------LHYDDRVSENQGLVQTYDHHLSSILALKY----FPDGSKFISS 311 Query: 225 SQDRYIRLWRIRIN----DLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGI--------- 271 S+D+ +R+W +IN + D ++ L + ++ Y + R+ Sbjct: 312 SEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKR 371 Query: 272 NFEALIMGHDDWIS--SLQWHESRLQLLAATADTSLMVWEPDETS 314 + + + GH SL + + + + + L W+ + + Sbjct: 372 HPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSR 416 Score = 85.3 bits (209), Expect = 1e-16, Method: Composition-based stats. Identities = 43/280 (15%), Positives = 92/280 (32%), Gaps = 43/280 (15%) Query: 155 CLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQE 214 +L + + +L+ GG + + I F + + +GH +K+L F Sbjct: 165 TTALKFLPKTGHLILSGGNDHTIKIWDFYHD------YECLRDFQGHNKPIKALRF---- 214 Query: 215 TPGDYLLCSGSQDRYIRLWRIRINDL------------IDDSEEDSKKLTLLSNKQYKFQ 262 T S S DR +++W + ++ + + + + Sbjct: 215 TEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILH 274 Query: 263 IDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLR 322 DD + H I +L++ + ++++ D ++ +WE Sbjct: 275 YDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE------------N 322 Query: 323 LGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGIS 382 + K S S F + H ++F ++ K + Sbjct: 323 QINVPIKQISDTAQHSMPFLNV----HPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFK 378 Query: 383 GATKDVT--DIAWSPSGEYLLATSLDQTTRLFAPWIYDAS 420 G + +A+S G Y+ + D +RLF W ++ S Sbjct: 379 GHSSAGYGISLAFSGDGRYICSG--DSKSRLFT-WDWNTS 415 Score = 65.3 bits (157), Expect = 1e-10, Method: Composition-based stats. Identities = 39/261 (14%), Positives = 88/261 (33%), Gaps = 61/261 (23%) Query: 11 FIGANKQTQVSDIHKVKK-IVAFGAGKTIALWDPIEP----------------------- 46 F G NK + + + ++ +++ +WD Sbjct: 202 FQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPH 261 Query: 47 -------------------NNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIW- 86 N+G+ T H + + +++ PD +S+SED V+IW Sbjct: 262 EFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321 Query: 87 KFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTI 146 + Q T Q +S + + + D I + ++ + Sbjct: 322 NQINVPIKQISDTAQ-HSMPFLNVHPSQNYFCAQSMDNRIYSFSL---KPKYKRHPKKIF 377 Query: 147 KKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELE--GHEDW 204 K +SL+ + +Y+ + G + +F + R++ ++ G++ Sbjct: 378 KGHSSAGYGISLAFSGDGRYICS-GDSKSRLFTWDW-------NTSRLLNNIKIPGNK-P 428 Query: 205 VKSLAFRHQETPGDYLLCSGS 225 + + + QET ++CSG+ Sbjct: 429 ITQVDWHPQET--SKVICSGA 447 Score = 61.1 bits (146), Expect = 2e-09, Method: Composition-based stats. Identities = 41/283 (14%), Positives = 95/283 (33%), Gaps = 56/283 (19%) Query: 173 TNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRL 232 +V+V + +S +V+ GH + +L F + +L+ SG D I++ Sbjct: 133 NDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKT---GHLILSGGNDHTIKI 189 Query: 233 WRIRI-NDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHE 291 W + + D + GH+ I +L++ E Sbjct: 190 WDFYHDYECLRDFQ---------------------------------GHNKPIKALRFTE 216 Query: 292 SRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHER 351 L+++ D S+ +W+ + L + T HE Sbjct: 217 DCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNP-------------HEF 263 Query: 352 MDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRL 411 + L+N K + +++ + + + + P G +++S D+T R+ Sbjct: 264 IVG-LSNSKILHYDDRVSENQGLVQ---TYDHHLSSILALKYFPDGSKFISSSEDKTVRI 319 Query: 412 FAPWIYDASGRKREIATWHEFSRPQIH-GYDMICVETVTDTRF 453 + I + ++ H +H + C +++ + + Sbjct: 320 WENQI-NVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIY 361 Score = 57.2 bits (136), Expect = 3e-08, Method: Composition-based stats. Identities = 64/400 (16%), Positives = 130/400 (32%), Gaps = 42/400 (10%) Query: 298 AATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLT 357 +++ D + E + + L E + F+ ++ + Sbjct: 73 SSSDDETSQASETQKED-QDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYP 131 Query: 358 -NGKTGSWRMWATKDNIICDQRL--GISGATKDVTDIAWSP-SGEYLLATSLDQTTRLFA 413 N R +++ G + T + + P +G +L+ D T +++ Sbjct: 132 PNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWD 191 Query: 414 PWIYDASGRKREIATWHEFSRPQIHGYDMICVE-TVTDTRFVSGGDEKILRSFDLPKGVA 472 + + +F Q H + + T F+S ++ ++ +D G Sbjct: 192 FY--------HDYECLRDF---QGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKV 240 Query: 473 GMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPD--ITDPL 530 + +S P + ++GLSN + +D E G +T D ++ L Sbjct: 241 KTRLHLNSTPADVESR-PTNPHEFIVGLSNS--KILHYDDRVSENQGLVQTYDHHLSSIL 297 Query: 531 SLLECP-------PMEDQLQR----HLLWPEVEKLYGHGFEITCLDISPDQKLIASACRS 579 +L P ED+ R + P + + L++ P Q + Sbjct: 298 ALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMD 357 Query: 580 NNVQNAVIRIFSTENWLEIKPALPFHSLTI--TRLKFSKDGKFLLSVCRDRKWALWERNM 637 N + + ++ + K HS L FS DG+++ S + W+ N Sbjct: 358 NRIYSFSLK---PKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNT 414 Query: 638 EDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDK 677 ++ KP I DW P E V + + K Sbjct: 415 SRLLNNIKIPGNKP----ITQVDWHPQETSKVICSGAAGK 450 Score = 46.8 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 32/185 (17%), Positives = 57/185 (30%), Gaps = 44/185 (23%) Query: 551 VEKLYGHGFEITCLDISP-DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTI 609 + GH T L P LI S + I+I+ + E H+ I Sbjct: 155 IRNYPGHPEGTTALKFLPKTGHLILSGGNDHT-----IKIWDFYHDYECLRDFQGHNKPI 209 Query: 610 TRLKFSKDGKFLLSVCRDRKWALWERNM-------------------------------- 637 L+F++D + LS DR +W+ Sbjct: 210 KALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSN 269 Query: 638 ------EDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADD 691 +D E + + + G+ F+++S DKTV++W +Q Sbjct: 270 SKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIK 329 Query: 692 YVLEA 696 + + Sbjct: 330 QISDT 334 Score = 39.9 bits (91), Expect = 0.005, Method: Composition-based stats. Identities = 28/189 (14%), Positives = 70/189 (37%), Gaps = 28/189 (14%) Query: 279 GHDDWISSLQW-HESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGS 337 GH + ++L++ ++ +L+ D ++ +W+ E G Sbjct: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF----------YHDYECLRDFQ----GH 205 Query: 338 SGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSG 397 + + + + FL++ S ++W T+ + RL ++ DV +P Sbjct: 206 NKPIKALRFTEDCQS--FLSSSFDRSVKIWDTETGKV-KTRLHLNSTPADVESRPTNPH- 261 Query: 398 EYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGG 457 E+++ S + + + + G + H S Y ++F+S Sbjct: 262 EFIVGLSNSKILH-YDDRVSENQGLVQTYD--HHLSSILALKYFP------DGSKFISSS 312 Query: 458 DEKILRSFD 466 ++K +R ++ Sbjct: 313 EDKTVRIWE 321 >5WYK-BB nrPDB Length = 943 Score = 133 bits (334), Expect = 3e-31, Method: Composition-based stats. Identities = 121/693 (17%), Positives = 226/693 (32%), Gaps = 114/693 (16%) Query: 21 SDIHKVKKIVAFG-AGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASE 79 + HK ++A G A I +WD + +K V GH+A +T ++F ++S S+ Sbjct: 85 LEAHKDTDLLAVGYADGVIKVWDLM---SKTVLLNFNGHKAAITLLQFDGTGTRLISGSK 141 Query: 80 DHHVKIWKFTDYSHLQCIQTIQHYSKTIVA-LSALPSLISVGCADGTISIWRQNIQNDEF 138 D ++ +W + ++ + +I + DG I +W Sbjct: 142 DSNIIVWDLVGEVG---LYKLRSHKDSITGFWCQGEDWLISTSKDGMIKLWDLKTHQ--- 195 Query: 139 GLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAEL 198 G + L + LL GT+ V I + + + + Sbjct: 196 -CIETHIAHTGECWGLAVKDD-------LLITTGTDSQVKIWKLDIENDKMGGKLTEMGI 247 Query: 199 EGHEDWVKSLA--FRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTL--- 253 + + L F + + D+ I +RIR + I + +K Sbjct: 248 FEKQSKQRGLKIEFITNSSDKTSFFYIQNADKTIETFRIRKEEEIARGLKKREKRLKEKG 307 Query: 254 LSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQW---HESRLQLLAATADTSLMVWEP 310 L+ ++ I + I + I S W S+L+L+ T+ ++ + Sbjct: 308 LTEEEIAKSIKESYSSFILHPFQTIRSLYKIKSASWTTVSSSKLELVLTTSSNTIEYYSI 367 Query: 311 DETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATK 370 L + + G S ++ +NG S ++W K Sbjct: 368 PYEKRDPTSPAPLKTHTIELQ----GQRTDVRSIDISDDNKLLATASNG---SLKIWNIK 420 Query: 371 DNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLF---APWIYDASGRKREIA 427 + C + A + P G ++ + + +LF + + D + A Sbjct: 421 THK-CIRTFECGYA----LTCKFLPGGLLVILGTRNGELQLFDLASSSLLDTIEDAHDAA 475 Query: 428 TWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKS 487 W T R V+G +K ++ +D E S Sbjct: 476 IW-------------SLDLTSDGKRLVTGSADKTVKFWDFKV---------------ENS 507 Query: 488 EMPDSAT--VPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRH 545 +P + +PVL L + T ++TD + + P + L Sbjct: 508 LVPGTKNKFLPVLKLHHDT------------------TLELTDDILCVRVSPDDRYLAIS 549 Query: 546 LLWPEVEK-----------LYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTEN 594 LL V+ LYGH + +DIS D K+I ++ N I+I+ + Sbjct: 550 LLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKN-----IKIWGLDF 604 Query: 595 WLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTR 654 K H +I +KF S +D W+ FE K H Sbjct: 605 GDCHKSLF-AHQDSIMNVKFLPQSHNFFSCSKDAVVKYWDGEK----FECIQKLYA-HQS 658 Query: 655 IIWDADWAPLEFGNVFVTASRDKTVKVWRHQKE 687 +W A G V++S D ++++W ++ Sbjct: 659 EVW--ALAVATDGGFVVSSSHDHSIRIWEETED 689 Score = 131 bits (329), Expect = 1e-30, Method: Composition-based stats. Identities = 69/483 (14%), Positives = 161/483 (33%), Gaps = 65/483 (13%) Query: 11 FIGANKQTQVSDIH-KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVP 69 F G + ++++ I +WD + L+ H+ +T + Sbjct: 117 FNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGEVG---LYKLRSHKDSITGF-WCQ 172 Query: 70 DSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIW 129 D+++S S+D +K+W + QCI+T ++ L+ L+ D + IW Sbjct: 173 GEDWLISTSKDGMIKLWDLKTH---QCIETHIAHTGECWGLAVKDDLLITTGTDSQVKIW 229 Query: 130 RQNIQND-------EFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASF 182 + +I+ND E G+ + + ++G + S Y+ T I Sbjct: 230 KLDIENDKMGGKLTEMGIFEKQSKQRGLKIEFITNSSDKTSFFYIQNADKTIETFRIRKE 289 Query: 183 ILSDSGIEKCRVVAELEGHEDWV---------KSLAFRHQETPGD-YLLCSGSQDRYIRL 232 G++K + +G + S +T Y + S S + Sbjct: 290 EEIARGLKKREKRLKEKGLTEEEIAKSIKESYSSFILHPFQTIRSLYKIKSASW-TTV-- 346 Query: 233 WRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHES 292 +L+ + ++ + + ++ L+ + G + S+ + Sbjct: 347 -SSSKLELVLTTSSNTIEYYSIPYEKRDPTSPAPLKTHT---IELQGQRTDVRSIDISDD 402 Query: 293 RLQLLAATADTSLMVWEPDETSGI--WVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHE 350 +LLA ++ SL +W I + C L Sbjct: 403 N-KLLATASNGSLKIWNIKTHKCIRTFECGYALTCKFL---------------------P 440 Query: 351 RMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTR 410 + + G +++ + + D + + + G+ L+ S D+T + Sbjct: 441 GGLLVILGTRNGELQLFDLASSSLLDTIED--AHDAAIWSLDLTSDGKRLVTGSADKTVK 498 Query: 411 LFAPWIYDA-----SGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVS-GGDEKILRS 464 + + ++ + + H + ++ D++CV D R+++ + ++ Sbjct: 499 FWDFKVENSLVPGTKNKFLPVLKLHHDTTLEL-TDDILCVRVSPDDRYLAISLLDNTVKV 557 Query: 465 FDL 467 F L Sbjct: 558 FFL 560 Score = 99.6 bits (246), Expect = 5e-21, Method: Composition-based stats. Identities = 51/323 (15%), Positives = 114/323 (35%), Gaps = 38/323 (11%) Query: 11 FIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPD 70 G + DI K++A + ++ +W+ T + +F+P Sbjct: 387 LQGQRTDVRSIDISDDNKLLATASNGSLKIWNI---KTHKCIRTFE--CGYALTCKFLPG 441 Query: 71 SDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWR 130 ++ + + ++++ S L I+ + + L++ + G AD T+ W Sbjct: 442 GLLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWD 501 Query: 131 QNIQND----------EFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIA 180 ++N H T + LC+ +S + +Y LAI + V + Sbjct: 502 FKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVS--PDDRY-LAISLLDNTVKV- 557 Query: 181 SFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI---RI 237 ++ + L GH+ V S+ ++ + S D+ I++W + Sbjct: 558 ------FFLDSMKFYLSLYGHKLPVLSIDISF----DSKMIITSSADKNIKIWGLDFGDC 607 Query: 238 NDLIDDSEEDSKKLTLLSNKQYKFQIDDELRV----GINFE--ALIMGHDDWISSLQWHE 291 + + ++ + L F + V G FE + H + +L Sbjct: 608 HKSLFAHQDSIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQKLYAHQSEVWALAVAT 667 Query: 292 SRLQLLAATADTSLMVWEPDETS 314 +++++ D S+ +WE E Sbjct: 668 DGGFVVSSSHDHSIRIWEETEDQ 690 Score = 99.2 bits (245), Expect = 6e-21, Method: Composition-based stats. Identities = 46/246 (18%), Positives = 81/246 (32%), Gaps = 41/246 (16%) Query: 13 GANKQTQVSDIHKV-KKIVAFGAGKTIALWD------PIEPNNKGVYATLKGH------- 58 + D+ K++V A KT+ WD + LK H Sbjct: 471 AHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLEL 530 Query: 59 EAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVAL--SALPSL 116 ++ CVR PD ++ + D+ VK++ + + ++++ S + Sbjct: 531 TDDILCVRVSPDDRYLAISLLDNTVKVFFLDSMKFYLSLY---GHKLPVLSIDISFDSKM 587 Query: 117 ISVGCADGTISIWRQNIQNDEFGL-AHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNV 175 I AD I IW + + L AH+ +I F P N Sbjct: 588 IITSSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQ-----------------SHNF 630 Query: 176 NVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI 235 ++ EK + +L H+ V +LA + S S D IR+W Sbjct: 631 FSCSKDAVVKYWDGEKFECIQKLYAHQSEVWALAVA----TDGGFVVSSSHDHSIRIWEE 686 Query: 236 RINDLI 241 + + Sbjct: 687 TEDQVF 692 Score = 67.2 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 18/81 (22%), Positives = 33/81 (40%), Gaps = 3/81 (3%) Query: 9 AIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFV 68 ++F + V + + + + WD L H++EV + Sbjct: 610 SLFAHQDSIMNVKFLPQSHNFFSCSKDAVVKYWD---GEKFECIQKLYAHQSEVWALAVA 666 Query: 69 PDSDFMVSASEDHHVKIWKFT 89 D F+VS+S DH ++IW+ T Sbjct: 667 TDGGFVVSSSHDHSIRIWEET 687 Score = 48.4 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 43/228 (18%), Positives = 79/228 (34%), Gaps = 39/228 (17%) Query: 560 EITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGK 619 E T L+ D L+A + VI+++ + + H IT L+F G Sbjct: 81 ECTYLEAHKDTDLLAVG-----YADGVIKVWDLMSKT-VLLNFNGHKAAITLLQFDGTGT 134 Query: 620 FLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTV 679 L+S +D +W+ E ++LR + DW ++ S+D + Sbjct: 135 RLISGSKDSNIIVWDLVGEVGLYKLRSHKDSITGFWCQGEDW--------LISTSKDGMI 186 Query: 680 KVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKF 739 K+W + +E I HT +++ D + L + Sbjct: 187 KLWDLKTHQC----IETHIAHTGECWGLAVKDDL-----------------LITTGTDSQ 225 Query: 740 ELITQL---NEDITPADKITRLRWSHLKRNG-KLFLGVGSSDLSTRIY 783 I +L N+ + + K+ G K+ SSD ++ Y Sbjct: 226 VKIWKLDIENDKMGGKLTEMGIFEKQSKQRGLKIEFITNSSDKTSFFY 273 Score = 35.6 bits (80), Expect = 0.079, Method: Composition-based stats. Identities = 36/199 (18%), Positives = 64/199 (32%), Gaps = 22/199 (11%) Query: 559 FEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDG 618 P L+ R+ +Q +F + + H I L + DG Sbjct: 431 GYALTCKFLPGGLLVILGTRNGELQ-----LFDLASSSLLDTIEDAHDAAIWSLDLTSDG 485 Query: 619 KFLLSVCRDRKWALWERNMED-------NTFELRFKNEKPHTRIIWDADWAPLEFGNVFV 671 K L++ D+ W+ +E+ N F K T + D + Sbjct: 486 KRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRY 545 Query: 672 TASR--DKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEI 729 A D TVKV+ + + L + H V +I D K++I+ + I Sbjct: 546 LAISLLDNTVKVFFLD---SMKFYL-SLYGHKLPVLSI---DISFDSKMIITSSADKN-I 597 Query: 730 YLYSYTLGKFELITQLNED 748 ++ G ++D Sbjct: 598 KIWGLDFGDCHKSLFAHQD 616 >6QX9-4B nrPDB Length = 522 Score = 130 bits (325), Expect = 3e-30, Method: Composition-based stats. Identities = 50/306 (16%), Positives = 97/306 (31%), Gaps = 50/306 (16%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDF--------MVS 76 K + LW + + TL+GH V + F P S + S Sbjct: 242 NSKMLATACWSGLCKLWSVP---DCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLAS 298 Query: 77 ASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS--LISVGCADGTISIWRQNIQ 134 + D VK+W + + I+ ++ + + PS + C D + +W Q Sbjct: 299 CAADGSVKLWSLD---SDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQ 355 Query: 135 NDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRV 194 + + H+ G + ++ ++ L GG + + + R Sbjct: 356 EE---ILHQEGHSMGVY-----DIAFHQDGS-LAGTGGLDAFGRVW-------DLRTGRC 399 Query: 195 VAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLI------------D 242 + LEGH + + F P Y + +GS D ++W +R + Sbjct: 400 IMFLEGHLKEIYGINFS----PNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGV 455 Query: 243 DSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATAD 302 E L +I G + + GH+ + L + + D Sbjct: 456 KFEPIHGNFLLTGAYDNTAKIWT--HPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYD 513 Query: 303 TSLMVW 308 + +W Sbjct: 514 RTFKLW 519 Score = 125 bits (312), Expect = 1e-28, Method: Composition-based stats. Identities = 49/372 (13%), Positives = 115/372 (30%), Gaps = 87/372 (23%) Query: 52 YATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALS 111 + + G + ++ F P+S + +A K+W D + T++ ++ + A+ Sbjct: 224 FCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDC---NLLHTLRGHNTNVGAIV 280 Query: 112 ALPSL----------ISVGCADGTISIWRQNIQNDEFGL-AHEFTIKKGFFYPLCLSLSK 160 P ++ ADG++ +W + + H + + ++P Sbjct: 281 FHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPS------ 334 Query: 161 VEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYL 220 L + + + + + + EGH V +AF L Sbjct: 335 ----GRFLGTTCYDRSWRLWDLEAQEEILHQ-------EGHSMGVYDIAFHQ----DGSL 379 Query: 221 LCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGH 280 +G D + R+W +R + ++ GH Sbjct: 380 AGTGGLDAFGRVWDLRT-------------------GRCIMFLE--------------GH 406 Query: 281 DDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGG 340 I + + + + + D + VW+ + ++ Sbjct: 407 LKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPA----------------HQN 450 Query: 341 FWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYL 400 + + F +F LT + ++W + ++G V + S G+ + Sbjct: 451 LVTGVKFEPIHGNFLLTGAYDNTAKIW---THPGWSPLKTLAGHEGKVMGLDISSDGQLI 507 Query: 401 LATSLDQTTRLF 412 S D+T +L+ Sbjct: 508 ATCSYDRTFKLW 519 Score = 118 bits (295), Expect = 1e-26, Method: Composition-based stats. Identities = 43/231 (18%), Positives = 74/231 (32%), Gaps = 30/231 (12%) Query: 7 PEAIFIGANKQTQVSDIHKVKKIV-AFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCV 65 P A G + H + + ++ LWD +GH V + Sbjct: 315 PVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEE---ILHQEGHSMGVYDI 371 Query: 66 RFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSL--ISVGCAD 123 F D + D ++W CI ++ + K I ++ P+ I+ G D Sbjct: 372 AFHQDGSLAGTGGLDAFGRVWDLRTGR---CIMFLEGHLKEIYGINFSPNGYHIATGSGD 428 Query: 124 GTISIWRQNIQNDEFGL-AHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASF 182 T +W + + + AH+ + F P+ + L G + I + Sbjct: 429 NTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNF---------LLTGAYDNTAKIWTH 479 Query: 183 ILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW 233 + L GHE V L L+ + S DR +LW Sbjct: 480 PGWSP-------LKTLAGHEGKVMGLDIS----SDGQLIATCSYDRTFKLW 519 Score = 76.5 bits (186), Expect = 5e-14, Method: Composition-based stats. Identities = 73/419 (17%), Positives = 132/419 (31%), Gaps = 81/419 (19%) Query: 228 RYIRLW----RIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDW 283 + RLW + + K++ + ++ LR NF + I G D Sbjct: 175 KVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQI-GDDRP 233 Query: 284 ISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWS 343 IS + + L A +W + +LR G +T G+ Sbjct: 234 ISYCHFSPNSKMLATACWSGLCKLWSV--PDCNLLHTLR-------GHNTNVGAIVFHPK 284 Query: 344 CLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLAT 403 + + GS ++W+ + I G T V + W PSG +L T Sbjct: 285 STVSLDPKDVNLASCAADGSVKLWSLDSDEPVA---DIEGHTVRVARVMWHPSGRFLGTT 341 Query: 404 SLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKILR 463 D++ RL+ +E E + YD+ + + +GG + R Sbjct: 342 CYDRSWRLWDL-------EAQEEILHQEGHSMGV--YDIAFHQ--DGSLAGTGGLDAFGR 390 Query: 464 SFDLPKG-----VAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEG 518 +DL G + G L++ GI F P+ + + +G++ D + Sbjct: 391 VWDLRTGRCIMFLEGHLKEIYGINFS-----PNGYHI-----ATGSGDNTCKVWDLRQR- 439 Query: 519 GNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISP-DQKLIASAC 577 V + H +T + P + + Sbjct: 440 -------------------RC-----------VYTIPAHQNLVTGVKFEPIHGNFLLTGA 469 Query: 578 RSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERN 636 N +I++ W +K L H + L S DG+ + + DR + LW Sbjct: 470 YDNTA-----KIWTHPGWSPLK-TLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 522 Score = 63.4 bits (152), Expect = 4e-10, Method: Composition-based stats. Identities = 36/217 (16%), Positives = 78/217 (35%), Gaps = 51/217 (23%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQ----NAVIRIFSTENWLEIKPALPFHS 606 + L GH + + P + ++ + N+ + ++++S ++ E + H+ Sbjct: 266 LHTLRGHNTNVGAIVFHP-KSTVSLDPKDVNLASCAADGSVKLWSLDSD-EPVADIEGHT 323 Query: 607 LTITRLKFSKDGKFLLSVCRDRKWALWERNMED----------NTFELRFKNEK------ 650 + + R+ + G+FL + C DR W LW+ ++ +++ F + Sbjct: 324 VRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTG 383 Query: 651 ---------------------PHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPA 689 H + I+ +++P G T S D T KVW ++ Sbjct: 384 GLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSP--NGYHIATGSGDNTCKVWDLRQRRC 441 Query: 690 DDYVLEASIKHTKAVTAISIHDSMIREKILISVGLEN 726 + H VT + I L++ +N Sbjct: 442 ----VYTIPAHQNLVTGVKFEP--IHGNFLLTGAYDN 472 Score = 63.0 bits (151), Expect = 5e-10, Method: Composition-based stats. Identities = 32/133 (24%), Positives = 50/133 (37%), Gaps = 14/133 (10%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 + L GH EI ++ SP+ IA+ N + +R +P H +T Sbjct: 400 IMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRC------VYTIPAHQNLVT 453 Query: 611 RLKFSK-DGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNV 669 +KF G FLL+ D +W + K H + D + G + Sbjct: 454 GVKFEPIHGNFLLTGAYDNTAKIW-----THPGWSPLKTLAGHEGKVMGLDIS--SDGQL 506 Query: 670 FVTASRDKTVKVW 682 T S D+T K+W Sbjct: 507 IATCSYDRTFKLW 519 Score = 58.0 bits (138), Expect = 2e-08, Method: Composition-based stats. Identities = 29/176 (16%), Positives = 58/176 (32%), Gaps = 19/176 (10%) Query: 550 EVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTI 609 E+ GH + + D L + +A R++ I L H I Sbjct: 357 EILHQEGHSMGVYDIAFHQDGSLAGTGG-----LDAFGRVWDLRTGRCIMF-LEGHLKEI 410 Query: 610 TRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNV 669 + FS +G + + D +W+ + + H ++ + P+ N Sbjct: 411 YGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTI-----PAHQNLVTGVKFEPIHG-NF 464 Query: 670 FVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLE 725 +T + D T K+W H L+ H V + D +++ + + Sbjct: 465 LLTGAYDNTAKIWTHPG----WSPLKTLAGHEGKVMGL---DISSDGQLIATCSYD 513 Score = 52.6 bits (124), Expect = 6e-07, Method: Composition-based stats. Identities = 20/110 (18%), Positives = 33/110 (30%), Gaps = 5/110 (4%) Query: 604 FHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKN-EKPHTRIIWDADWA 662 I+ FS + K L + C LW + LR N + + Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288 Query: 663 PLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDS 712 + + D +VK+W + + HT V + H S Sbjct: 289 LDPKDVNLASCAADGSVKLWSLDSDEP----VADIEGHTVRVARVMWHPS 334 >3BG0-A nrPDB Length = 316 Score = 125 bits (312), Expect = 1e-28, Method: Composition-based stats. Identities = 51/311 (16%), Positives = 108/311 (34%), Gaps = 53/311 (17%) Query: 26 VKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPD--SDFMVSASEDHHV 83 ++ + +++ ++D + A L+GHE V V + + + S S D V Sbjct: 25 GTRLATCSSDRSVKIFDVRNGGQI-LIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKV 83 Query: 84 KIWKFTDYSHLQCIQTIQHYSKTIVALSALPS----LISVGCADGTISIWRQNIQND--- 136 IW+ + + + + ++ ++ P +++ G +DG IS+ + Sbjct: 84 IIWREENGTWEKS-HEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEV 142 Query: 137 -EFGLAHEFTIKKGFFYPLCLSLSKV-------EEKKYLLAIGGTNVNVFIASFILSDSG 188 + AH + P + S + A GG + + + Sbjct: 143 KKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQW 202 Query: 189 IEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDS 248 E+ ++ A H DWV+ +A+ + S SQD + +W DD+ ++ Sbjct: 203 KEEQKLEA----HSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW------TCDDASSNT 252 Query: 249 KKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVW 308 L + +D + + W + L + D + +W Sbjct: 253 WSPKL-----------------------LHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 Query: 309 EPDETSGIWVC 319 + + G WVC Sbjct: 290 K-ESVDGQWVC 299 Score = 64.5 bits (155), Expect = 2e-10, Method: Composition-based stats. Identities = 42/306 (13%), Positives = 91/306 (29%), Gaps = 40/306 (13%) Query: 114 PSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGT 173 + ++ +D ++ I+ +++N L + +G + + + +LA Sbjct: 25 GTRLATCSSDRSVKIF--DVRNGGQILIADLRGHEGPVWQVAWAHPMYGN---ILASCSY 79 Query: 174 NVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW 233 + V I E GH+ V S+ + + +L GS D I L Sbjct: 80 DRKVIIWREENGTWEKSH-----EHAGHDSSVNSVCWAPHDY--GLILACGSSDGAISL- 131 Query: 234 RIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESR 293 + + E ++ + N + + ++ H Q Sbjct: 132 -------LTYTGEGQWEVKKI-NNAHTIGCNAVSWAPAVVPGSLIDHPSG----QKPNYI 179 Query: 294 LQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMD 353 + + D + +W+ +E G W +L S W + Sbjct: 180 KRFASGGCDNLIKLWK-EEEDGQWKEEQKL-----------EAHSDWVRDVAWAPSIGLP 227 Query: 354 F--FLTNGKTGSWRMWATKDNIICDQRLGISGATKDV-TDIAWSPSGEYLLATSLDQTTR 410 + + G +W D + DV ++WS + L + D Sbjct: 228 TSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVT 287 Query: 411 LFAPWI 416 L+ + Sbjct: 288 LWKESV 293 Score = 60.3 bits (144), Expect = 3e-09, Method: Composition-based stats. Identities = 32/170 (18%), Positives = 61/170 (35%), Gaps = 9/170 (5%) Query: 584 NAVIRIFSTENWLEIKPA-LPFHSLTITRLKFSKD--GKFLLSVCRDRKWALWERNMEDN 640 + ++IF N +I A L H + ++ ++ G L S DRK +W Sbjct: 34 DRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTW 93 Query: 641 TFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKH 700 + H + WAP ++G + S D + + + E + V + + H Sbjct: 94 E---KSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWE-VKKINNAH 149 Query: 701 TKAVTAISIHDSMIREKILI--SVGLENGEIYLYSYTLGKFELITQLNED 748 T A+S +++ ++ S N S + + ED Sbjct: 150 TIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEED 199 Score = 58.8 bits (140), Expect = 9e-09, Method: Composition-based stats. Identities = 54/304 (17%), Positives = 98/304 (32%), Gaps = 56/304 (18%) Query: 172 GTNVNVFIASFILSDSGIEKCR--VVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRY 229 GT + + + + ++A+L GHE V +A+ H +L S S DR Sbjct: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMY--GNILASCSYDRK 82 Query: 230 IRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQW 289 + +WR E GHD ++S+ W Sbjct: 83 VIIWREENGTWEKSHEH-------------------------------AGHDSSVNSVCW 111 Query: 290 HES--RLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWF 347 L L ++D ++ + G W ++ + A + Sbjct: 112 APHDYGLILACGSSDGAISLLTY-TGEGQW--EVKKINNAHTIGCNAVSWAPAVVPGSLI 168 Query: 348 THE------RMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPS----G 397 H + F + G ++W +++ + + + V D+AW+PS Sbjct: 169 DHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPT 228 Query: 398 EYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGG 457 + + S D ++ DAS H+F+ H I + VSGG Sbjct: 229 STIASCSQDGRVFIWTCD--DASSNTWSPKLLHKFNDVVWHVSWSITANILA----VSGG 282 Query: 458 DEKI 461 D K+ Sbjct: 283 DNKV 286 Score = 53.8 bits (127), Expect = 3e-07, Method: Composition-based stats. Identities = 34/199 (17%), Positives = 61/199 (30%), Gaps = 25/199 (12%) Query: 278 MGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGS 337 H+D I Q +L ++D S+ +++ I + LR G Sbjct: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLR-------------GH 56 Query: 338 SGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPS- 396 G W W + + +W ++N ++ +G V + W+P Sbjct: 57 EGPVWQVAWAHPMYGNILASCSYDRKVIIWR-EENGTWEKSHEHAGHDSSVNSVCWAPHD 115 Query: 397 -GEYLLATSLDQTTRLFA---------PWIYDASGRKREIATWHEFSRPQIHGYDMICVE 446 G L S D L I +A +W P + Sbjct: 116 YGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQK 175 Query: 447 TVTDTRFVSGGDEKILRSF 465 RF SGG + +++ + Sbjct: 176 PNYIKRFASGGCDNLIKLW 194 Score = 45.7 bits (106), Expect = 8e-05, Method: Composition-based stats. Identities = 27/131 (20%), Positives = 53/131 (40%), Gaps = 7/131 (5%) Query: 605 HSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPL 664 H I + G L + DR +++ N ++ + + H +W WA Sbjct: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVR---NGGQILIADLRGHEGPVWQVAWAHP 68 Query: 665 EFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGL 724 +GN+ + S D+ V +WR + + A H +V ++ ++++ G Sbjct: 69 MYGNILASCSYDRKVIIWREENGTWEKSHEHA--GHDSSVNSVCWAPHDYG--LILACGS 124 Query: 725 ENGEIYLYSYT 735 +G I L +YT Sbjct: 125 SDGAISLLTYT 135 Score = 45.3 bits (105), Expect = 1e-04, Method: Composition-based stats. Identities = 30/202 (14%), Positives = 66/202 (32%), Gaps = 26/202 (12%) Query: 551 VEKLYGHGFEITCLD-ISPD-QKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLT 608 + L GH + + P ++AS + VI E H + Sbjct: 50 IADLRGHEGPVWQVAWAHPMYGNILAS----CSYDRKVIIWREENGTWEKSHEHAGHDSS 105 Query: 609 ITRLKFSKD--GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEF 666 + + ++ G L D +L + +E++ N HT WAP Sbjct: 106 VNSVCWAPHDYGLILACGSSDGAISLL-TYTGEGQWEVKKINNA-HTIGCNAVSWAPAVV 163 Query: 667 G---------------NVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHD 711 F + D +K+W+ +++ + H+ V ++ Sbjct: 164 PGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEE-QKLEAHSDWVRDVAWAP 222 Query: 712 SMIREKILISVGLENGEIYLYS 733 S+ I+ ++G +++++ Sbjct: 223 SIGLPTSTIASCSQDGRVFIWT 244 Score = 45.3 bits (105), Expect = 1e-04, Method: Composition-based stats. Identities = 36/219 (16%), Positives = 76/219 (34%), Gaps = 25/219 (11%) Query: 548 WPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSL 607 W + + GH + + +P + AC S++ +++ W E+K H++ Sbjct: 93 WEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQW-EVKKINNAHTI 151 Query: 608 TITRLKFSK--------------DGKFL---LSVCRDRKWALWERNMEDNTFELRFKNEK 650 + ++ ++ S D LW+ + E + + Sbjct: 152 GCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEE--QKLE 209 Query: 651 PHTRIIWDADWAPLEF--GNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAIS 708 H+ + D WAP + + S+D V +W ++ + + K V +S Sbjct: 210 AHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVS 269 Query: 709 IHDSMIREKILISVGLENGEIYLYSYTLGKFELITQLNE 747 I IL G +N G++ I+ +N+ Sbjct: 270 WS---ITANILAVSGGDNKVTLWKESVDGQWVCISDVNK 305 Score = 33.7 bits (75), Expect = 0.30, Method: Composition-based stats. Identities = 18/138 (13%), Positives = 33/138 (23%), Gaps = 51/138 (36%) Query: 24 HKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVP----DSDFMVSASE 79 + +K+ + G I LW E L+ H V V + P + + S S+ Sbjct: 177 NYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQ 236 Query: 80 DH----------------------------------------------HVKIWKFT-DYS 92 D V +WK + D Sbjct: 237 DGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQ 296 Query: 93 HLQCIQTIQHYSKTIVAL 110 + + ++ Sbjct: 297 WVCISDVNKGQGSVSASV 314 >5K19-A nrPDB Length = 569 Score = 124 bits (311), Expect = 1e-28, Method: Composition-based stats. Identities = 62/245 (25%), Positives = 107/245 (43%), Gaps = 40/245 (16%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKG-HEAEVTCVRFVPDSD--FMVSASEDH 81 V +V F AG+ + L DPI+ ++ + ++ VTCV++VP S+ F+V+ S + Sbjct: 115 SVSLLVGFSAGQ-VQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGN 173 Query: 82 ----HVKIWKFTDYSHLQCIQTIQHYS-KTIVALSALPSLISVGCADGTISIWRQN---- 132 +V+ T H Q ++ + ++ T + S L+ +G ++ + + Sbjct: 174 MYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGK 233 Query: 133 ----IQNDEFGLAHEF-------TIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIAS 181 + D F F T+K F LC+ S + KY++ GG + V + S Sbjct: 234 FLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWS--PDGKYIV-TGGEDDLVTVWS 290 Query: 182 FILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETP---GDYLLCSGSQDRY---IRLWRI 235 F+ CRV+A GH+ WV +AF T GD + SGS + + + R Sbjct: 291 FV-------DCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRD 343 Query: 236 RINDL 240 R N Sbjct: 344 RANST 348 Score = 60.7 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 30/220 (13%), Positives = 73/220 (33%), Gaps = 18/220 (8%) Query: 12 IGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDS 71 +G + + K + + +++ ++ ++ T+K + + CV + PD Sbjct: 218 VGEGALNEFAFSPDGKFLACVSQDGFLRVFNF---DSVELHGTMKSYFGGLLCVCWSPDG 274 Query: 72 DFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQ 131 ++V+ ED V +W F D I + + ++ P SV D Sbjct: 275 KYIVTGGEDDLVTVWSFVDCR---VIARGHGHKSWVSVVAFDPYTTSVEEGDPM----EF 327 Query: 132 NIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKK-----YLLAIGGTNVNVFIASFILSD 186 + +++F F + LS + + Y G + + + Sbjct: 328 SGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDI 387 Query: 187 SGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQ 226 + ++ H + V + + G+ + G+ Sbjct: 388 LFPH--QPLSRARTHTN-VMNATSPPAGSNGNSVTTPGNS 424 Score = 48.4 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 31/205 (15%), Positives = 71/205 (34%), Gaps = 29/205 (14%) Query: 558 GFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKD 617 + SPD K +A Q+ +R+F+ ++ +E+ + + + + +S D Sbjct: 220 EGALNEFAFSPDGKFLA-----CVSQDGFLRVFNFDS-VELHGTMKSYFGGLLCVCWSPD 273 Query: 618 GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADW--APLEFGNVFVTASR 675 GK++++ D +W + D R K ++ + + E + + S Sbjct: 274 GKYIVTGGEDDLVTVW--SFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSD 331 Query: 676 DKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYT 735 + + ++ A+ S +++ +S+ S Sbjct: 332 EDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSV------------------TYRFGSVG 373 Query: 736 LGKFELITQLNEDIT-PADKITRLR 759 + L EDI P ++R R Sbjct: 374 QDTQLCLWDLTEDILFPHQPLSRAR 398 Score = 41.4 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 29/198 (14%), Positives = 59/198 (29%), Gaps = 35/198 (17%) Query: 284 ISSLQWHE-SRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFW 342 ++ ++W S L A + ++ ++ + T G +L + A S Sbjct: 152 VTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKSTRN 211 Query: 343 SCLWFT-----------HERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDI 391 L +T F + G R++ + + + + Sbjct: 212 PLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHG---TMKSYFGGLLCV 268 Query: 392 AWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICV------ 445 WSP G+Y++ D +++ + +R H + V Sbjct: 269 CWSPDGKYIVTGGEDDLVTVWS-----------FVDC-RVIARGHGHKSWVSVVAFDPYT 316 Query: 446 ETVT--DTRFVSGGDEKI 461 +V D SG DE Sbjct: 317 TSVEEGDPMEFSGSDEDF 334 Score = 41.0 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 40/276 (14%), Positives = 81/276 (29%), Gaps = 43/276 (15%) Query: 202 EDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKF 261 + V + + L + L+ + + + + LL + Sbjct: 149 KSRVTCVKWVPGSE---SLFLVAHSSGNMYLYNV---EHTCGTTAPHYQ--LLKQGESFA 200 Query: 262 QIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSL 321 + + N + ++ + L + D L V+ D Sbjct: 201 VHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFD---------- 250 Query: 322 RLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGI 381 S + T GG W + + +T G+ +W+ D C Sbjct: 251 -----SVELHGTMKSYFGGLLCVCWSPDGK--YIVTGGEDDLVTVWSFVD---CRVIARG 300 Query: 382 SGATKDVTDIAWSP------SGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRP 435 G V+ +A+ P G+ + + D+ + + GR R +T S+ Sbjct: 301 HGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHF-----GRDRANSTQSRLSKR 355 Query: 436 QIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKGV 471 + V RF S G + L +DL + + Sbjct: 356 NSTDSRPVSVTY----RFGSVGQDTQLCLWDLTEDI 387 >6ID0-T nrPDB Length = 514 Score = 122 bits (305), Expect = 6e-28, Method: Composition-based stats. Identities = 53/356 (14%), Positives = 116/356 (32%), Gaps = 52/356 (14%) Query: 50 GVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVA 109 +Y + GH V C+ P + + V+ S D +KIW + + ++ Sbjct: 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVI- 253 Query: 110 LSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLA 169 +S + D + W + + Y L L + Sbjct: 254 VSTRSPYLFSCGEDKQVKCWDLE----YNKVIRHYHGHLSAVYGLDLHPTI--------- 300 Query: 170 IGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRY 229 + + V L GH + V ++ + E + +GS D Sbjct: 301 ---DVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAE----PQIITGSHDTT 353 Query: 230 IRLWRI---RINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGI------NFEALIMGH 280 IRLW + + + + ++ + + L + Y F + +F + GH Sbjct: 354 IRLWDLVAGKTRVTLTNHKKSVRAVVLHP-RHYTFASGSPDNIKQWKFPDGSFIQNLSGH 412 Query: 281 DDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGG 340 + I++L + + L++ + ++ +W+ W + + + S G Sbjct: 413 NAIINTLTVNSDGV-LVSGADNGTMHLWD-------WRTGYNFQRVHAAVQPGSLDSESG 464 Query: 341 FWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPS 396 ++C + E LT + +++ D AT++ ++W P Sbjct: 465 IFACAFDQSESR--LLTAEADKTIKVYREDDT-----------ATEETHPVSWKPE 507 Score = 121 bits (302), Expect = 1e-27, Method: Composition-based stats. Identities = 54/306 (17%), Positives = 96/306 (31%), Gaps = 54/306 (17%) Query: 10 IFIGA-NKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFV 68 G + V + + + G K + WD V GH + V + Sbjct: 241 SLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDL---EYNKVIRHYHGHLSAVYGLDLH 297 Query: 69 PDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISI 128 P D +V+ S D +IW + + + + T+ +A P I G D TI + Sbjct: 298 PTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQ-IITGSHDTTIRL 356 Query: 129 WRQNIQNDEFGL-AHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDS 187 W L H+ +++ +P Y A G + + Sbjct: 357 WDLVAGKTRVTLTNHKKSVRAVVLHPRH----------YTFASGSPDN--------IKQW 398 Query: 188 GIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEED 247 + L GH + +L +L SG+ + + LW R Sbjct: 399 KFPDGSFIQNLSGHNAIINTLTVNSDG-----VLVSGADNGTMHLWDWRTGYNFQ----- 448 Query: 248 SKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMV 307 RV + + + I + + +S +LL A AD ++ V Sbjct: 449 --------------------RVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKV 488 Query: 308 WEPDET 313 + D+T Sbjct: 489 YREDDT 494 Score = 88.8 bits (218), Expect = 8e-18, Method: Composition-based stats. Identities = 51/322 (15%), Positives = 103/322 (31%), Gaps = 55/322 (17%) Query: 164 KKYLLAIGGTNVNVFIASFILSDSGIE---KCRVVAELEGHEDWVKSLAFRHQETPGDYL 220 ++ G T + +A + + ++ + GH WV+ +A PG+ Sbjct: 163 NSIVMETGNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAV----EPGNQW 218 Query: 221 LCSGSQDRYIRLWRI---RINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVG------I 271 +GS DR I++W + ++ + + + + + Y F ++ +V Sbjct: 219 FVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYN 278 Query: 272 NFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGA 331 GH + L H + L+ + D++ +W+ + + S Sbjct: 279 KVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLS----------- 327 Query: 332 STATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDI 391 G + + +T + R+W + R+ ++ K V + Sbjct: 328 ----GHTNAVATVRC--QAAEPQIITGSHDTTIRLWDL---VAGKTRVTLTNHKKSVRAV 378 Query: 392 AWSPSGEYLLATSLDQTTRLFAP---WIYDASGRKREIATWHEFSRPQIHGYDMICVETV 448 P + S D + P +I + SG I T S Sbjct: 379 VLHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNS--------------- 423 Query: 449 TDTRFVSGGDEKILRSFDLPKG 470 D VSG D + +D G Sbjct: 424 -DGVLVSGADNGTMHLWDWRTG 444 Score = 87.3 bits (214), Expect = 2e-17, Method: Composition-based stats. Identities = 38/251 (15%), Positives = 84/251 (33%), Gaps = 22/251 (8%) Query: 11 FIGANKQTQVSDIH-KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVP 69 + G D+H + +V T +WD K TL GH V VR Sbjct: 284 YHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDV---RTKASVHTLSGHTNAVATVRCQA 340 Query: 70 DSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIW 129 +++ S D +++W + + + +V + G D I W Sbjct: 341 AEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRH-YTFASGSPD-NIKQW 398 Query: 130 RQ-NIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSG 188 + + + H I +L+ + + ++++ + Sbjct: 399 KFPDGSFIQNLSGHNAIIN---------TLTVNSDGVLVSGADNGTMHLWDWRTGYNFQR 449 Query: 189 IEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDS 248 + L+ E + + AF E+ L + D+ I+++R + +++ S Sbjct: 450 VHAAVQPGSLDS-ESGIFACAFDQSES----RLLTAEADKTIKVYR-EDDTATEETHPVS 503 Query: 249 KKLTLLSNKQY 259 K ++ K++ Sbjct: 504 WKPEIIKRKRF 514 Score = 83.8 bits (205), Expect = 2e-16, Method: Composition-based stats. Identities = 44/229 (19%), Positives = 87/229 (37%), Gaps = 22/229 (9%) Query: 522 ETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNN 581 ET + + + + P + Q H W + GH + C+ + P + + Sbjct: 168 ETGNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGS---- 223 Query: 582 VQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNT 641 + I+I+ + ++K +L H T+ + S +L S D++ W+ Sbjct: 224 -ADRTIKIWDLASG-KLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLE----- 276 Query: 642 FELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHT 701 + ++ H ++ D P +V VT SRD T ++W + + + + HT Sbjct: 277 YNKVIRHYHGHLSAVYGLDLHP--TIDVLVTCSRDSTARIWDVRTKAS----VHTLSGHT 330 Query: 702 KAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKFELITQLNEDIT 750 AV + E +I+ + I L+ GK +T N + Sbjct: 331 NAVATVR---CQAAEPQIITGSHD-TTIRLWDLVAGK-TRVTLTNHKKS 374 Score = 58.8 bits (140), Expect = 1e-08, Method: Composition-based stats. Identities = 63/328 (19%), Positives = 114/328 (34%), Gaps = 46/328 (14%) Query: 381 ISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGY 440 ISG V IA P ++ + S D+T +++ ASG+ + T H + + Sbjct: 200 ISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDL----ASGKLKLSLTGHISTVRGV--- 252 Query: 441 DMICVETVTDTRFVSGGDEKILRSFDLP-----KGVAGMLQKFVGIQFEEKSEMPDSATV 495 + + S G++K ++ +DL + G L G+ T+ Sbjct: 253 ----IVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLH--------PTI 300 Query: 496 PVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQL------QRHLLWP 549 VL ++ + A D + T+ ++ + C E Q+ LW Sbjct: 301 DVLVTCSR--DSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWD 358 Query: 550 EVE-----KLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPF 604 V L H + + + P AS N I+ + + I+ L Sbjct: 359 LVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN------IKQWKFPDGSFIQ-NLSG 411 Query: 605 HSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPH-TRIIWDADWAP 663 H+ I L + DG L+S + LW+ N + + A Sbjct: 412 HNAIINTLTVNSDG-VLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAF 470 Query: 664 LEFGNVFVTASRDKTVKVWRHQKEPADD 691 + + +TA DKT+KV+R ++ Sbjct: 471 DQSESRLLTAEADKTIKVYREDDTATEE 498 Score = 50.3 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 48/322 (14%), Positives = 106/322 (32%), Gaps = 71/322 (22%) Query: 429 WHEFSRPQIHGYDMICVETVTDTR-FVSGGDEKILRSFDLPKG-----VAGMLQKFVGIQ 482 W + H + C+ + FV+G ++ ++ +DL G + G + G+ Sbjct: 194 WKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVI 253 Query: 483 FEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQL 542 +S P L GED K+ L Sbjct: 254 VSTRS--------PYL---FSCGED-------------KQV--------------KCWDL 275 Query: 543 QRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPAL 602 + + + + +GH + LD+ P ++ + R + RI+ + L Sbjct: 276 EYNKV---IRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTA-----RIWDVRTKASVH-TL 326 Query: 603 PFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWA 662 H+ + ++ +++ D LW+ L H + + Sbjct: 327 SGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLT-----NHKKSVRAVVLH 381 Query: 663 PLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISV 722 P + F + S D +K W + D ++ H + ++++ ++ Sbjct: 382 PRHYT--FASGSPD-NIKQW----KFPDGSFIQNLSGHNAIINTLTVN-----SDGVLVS 429 Query: 723 GLENGEIYLYSYTLG-KFELIT 743 G +NG ++L+ + G F+ + Sbjct: 430 GADNGTMHLWDWRTGYNFQRVH 451 >2HES-X nrPDB Length = 330 Score = 118 bits (295), Expect = 1e-26, Method: Composition-based stats. Identities = 43/218 (19%), Positives = 88/218 (40%), Gaps = 19/218 (8%) Query: 26 VKKIVAFGAGKTIALWDPIEPNNKG----VYATLKGHEAEVTCVRFVPDSDFMVSASEDH 81 + A T+++W E ++ + A ++GHE EV V + D ++ + S D Sbjct: 70 TSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDK 129 Query: 82 HVKIWKF-TDYSHLQCIQTIQHYSKTIVALSALPS--LISVGCADGTISIWRQNIQNDEF 138 V IW+ +CI +Q +S+ + + PS L++ D T+ IW+ +D++ Sbjct: 130 SVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKD--YDDDW 187 Query: 139 GLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEK-CRVVAE 197 +G + E + L G + V + ++ D ++ A Sbjct: 188 ECVAVLNGHEGTVWSSDFD---KTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAI 244 Query: 198 L-EGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWR 234 L + H+ V ++A+ L+ S D + ++ Sbjct: 245 LPDVHKRQVYNVAWGFNG-----LIASVGADGVLAVYE 277 Score = 109 bits (271), Expect = 6e-24, Method: Composition-based stats. Identities = 47/230 (20%), Positives = 84/230 (36%), Gaps = 31/230 (13%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATL--KGHEAEVTCVRFVPDSDFMVSASEDHHVKIW 86 + + I L + ++ + L H+ + V + P + + + S D V IW Sbjct: 27 LATGSTDRKIKLVSV-KYDDFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSFDSTVSIW 85 Query: 87 KFTDYS----HLQCIQTIQHYSKTIVALSA--LPSLISVGCADGTISIWRQNIQNDEFGL 140 + + + + I+ + + ++ ++ D ++ IW + +E+ Sbjct: 86 AKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYEC 145 Query: 141 A-----HEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVV 195 H +K ++P LLA + V I D V Sbjct: 146 ISVLQEHSQDVKHVIWHPSEA----------LLASSSYDDTVRIWKDYDDDWE-----CV 190 Query: 196 AELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSE 245 A L GHE V S F T G + LCSGS D +R+W+ +D D E Sbjct: 191 AVLNGHEGTVWSSDFDK--TEGVFRLCSGSDDSTVRVWKYMGDDEDDQQE 238 Score = 102 bits (253), Expect = 7e-22, Method: Composition-based stats. Identities = 62/377 (16%), Positives = 129/377 (34%), Gaps = 69/377 (18%) Query: 50 GVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTI--QHYSKTI 107 + +LK ++ ++ F + + S D +K+ Y I + + K I Sbjct: 5 NLIKSLKLYKEKIWSFDFSQG--ILATGSTDRKIKL-VSVKYDDFTLIDVLDETAHKKAI 61 Query: 108 VALSALP--SLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKK 165 +++ P SL++ G D T+SIW + D I +G + + Sbjct: 62 RSVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEG--HENEVKGVAWSNDG 119 Query: 166 YLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGS 225 Y LA + +V+I +D E+ ++ L+ H VK + + E LL S S Sbjct: 120 YYLATCSRDKSVWIWE---TDESGEEYECISVLQEHSQDVKHVIWHPSEA----LLASSS 172 Query: 226 QDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWIS 285 D +R+W+ +D A++ GH+ + Sbjct: 173 YDDTVRIWKDYDDDWEC-------------------------------VAVLNGHEGTVW 201 Query: 286 SLQWHESR--LQLLAATADTSLMVW----EPDETSGIWVCSLRLGEMSSKGASTATGSSG 339 S + ++ +L + + D+++ VW + ++ WVC L ++ Sbjct: 202 SSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDV----------HKR 251 Query: 340 GFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGA-TKDVTDIAW-SPSG 397 ++ W + G G ++ D ++ + W +G Sbjct: 252 QVYNVAW---GFNGLIASVGADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVKWLELNG 308 Query: 398 EYLL-ATSLDQTTRLFA 413 + +L D ++ Sbjct: 309 KTILATGGDDGIVNFWS 325 Score = 96.9 bits (239), Expect = 3e-20, Method: Composition-based stats. Identities = 67/389 (17%), Positives = 138/389 (35%), Gaps = 71/389 (18%) Query: 92 SHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFF 151 + + I++++ Y + I + +++ G D I + +++ D+F L Sbjct: 2 ASINLIKSLKLYKEKIWSFDFSQGILATGSTDRKIKL--VSVKYDDFTLIDVLDETAHKK 59 Query: 152 YPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFR 211 ++ LLA G + V I + S + ++A +EGHE+ VK +A+ Sbjct: 60 AIRSVAWR---PHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWS 116 Query: 212 HQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGI 271 + Y L + S+D+ + +W E + + ++ Sbjct: 117 N----DGYYLATCSRDKSVWIWE--------TDESGEEYECISVLQE------------- 151 Query: 272 NFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGA 331 H + + WH S L +++ D ++ +W+ + W C L Sbjct: 152 --------HSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDD--WECVAVLN------- 194 Query: 332 STATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMW-----ATKDNIICDQRLGISG-AT 385 G G WS + E + + + R+W D + Sbjct: 195 ----GHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHK 250 Query: 386 KDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHG-YDMIC 444 + V ++AW +G + + D ++ + G + A R HG Y++ Sbjct: 251 RQVYNVAWGFNG-LIASVGADGVLAVYE----EVDGEWKVFA-----KRALCHGVYEINV 300 Query: 445 VETVT---DTRFVSGGDEKILRSFDLPKG 470 V+ + T +GGD+ I+ + L K Sbjct: 301 VKWLELNGKTILATGGDDGIVNFWSLEKA 329 Score = 95.4 bits (235), Expect = 8e-20, Method: Composition-based stats. Identities = 35/230 (15%), Positives = 83/230 (36%), Gaps = 18/230 (7%) Query: 15 NKQTQVSDIHKVKKIVAFGAGKTIALWDPIE-PNNKGVYATLKGHEAEVTCVRFVPDSDF 73 N+ V+ + + K++ +W+ E + L+ H +V V + P Sbjct: 108 NEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEAL 167 Query: 74 MVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS----LISVGCADGTISIW 129 + S+S D V+IWK D +C+ + + T+ + + + G D T+ +W Sbjct: 168 LASSSYDDTVRIWKDYDDDW-ECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVW 226 Query: 130 R---QNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSD 186 + + + + + ++ L+A G + + + + + Sbjct: 227 KYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNG----LIASVGADGVLAVYEEVDGE 282 Query: 187 SGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIR 236 + R + H + ++ + E G +L +G D + W + Sbjct: 283 WKVFAKRALC----HGVYEINV-VKWLELNGKTILATGGDDGIVNFWSLE 327 Score = 86.9 bits (213), Expect = 3e-17, Method: Composition-based stats. Identities = 39/182 (21%), Positives = 71/182 (39%), Gaps = 15/182 (8%) Query: 605 HSLTITRLKFSKDGKFLLSVCRDRKWALW-ERNMEDNTFEL-RFKNEKPHTRIIWDADWA 662 H I + + L + D ++W + D TFE+ + H + W+ Sbjct: 57 HKKAIRSVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWS 116 Query: 663 PLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIK-HTKAVTAISIHDSMIREKILIS 721 G T SRDK+V +W E ++Y + ++ H++ V + H S E +L S Sbjct: 117 --NDGYYLATCSRDKSVWIWETD-ESGEEYECISVLQEHSQDVKHVIWHPS---EALLAS 170 Query: 722 VGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTR 781 ++ + ++ +E + LN + T K G L GS D + R Sbjct: 171 SSYDD-TVRIWKDYDDDWECVAVLN-----GHEGTVWSSDFDKTEGVFRLCSGSDDSTVR 224 Query: 782 IY 783 ++ Sbjct: 225 VW 226 Score = 76.5 bits (186), Expect = 4e-14, Method: Composition-based stats. Identities = 55/256 (21%), Positives = 99/256 (38%), Gaps = 24/256 (9%) Query: 538 MEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLE 597 E+ R + + GH E+ + S D +A+ R + + I+ T+ E Sbjct: 87 KEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKS-----VWIWETDESGE 141 Query: 598 IK---PALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTR 654 L HS + + + L S D +W+ +D +E H Sbjct: 142 EYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDD--WECVAVLN-GHEG 198 Query: 655 IIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADD---YVLEASIK--HTKAVTAISI 709 +W +D+ E + S D TV+VW++ + DD +V EA + H + V ++ Sbjct: 199 TVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAW 258 Query: 710 HDSMIREKILISVGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKL 769 ++ SVG + G + +Y G++ + +I ++W L+ NGK Sbjct: 259 G----FNGLIASVGAD-GVLAVYEEVDGEW-KVFAKRALCHGVYEINVVKW--LELNGKT 310 Query: 770 FLGVGSSDLSTRIYSL 785 L G D +SL Sbjct: 311 ILATGGDDGIVNFWSL 326 Score = 71.5 bits (173), Expect = 1e-12, Method: Composition-based stats. Identities = 36/196 (18%), Positives = 74/196 (37%), Gaps = 18/196 (9%) Query: 548 WPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKP------A 601 +V H I + P L+A+ + + I++ E + Sbjct: 48 LIDVLDETAHKKAIRSVAWRPHTSLLAAGSFDST-----VSIWAKEESADRTFEMDLLAI 102 Query: 602 LPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADW 661 + H + + +S DG +L + RD+ +WE + +E ++ H++ + W Sbjct: 103 IEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQE-HSQDVKHVIW 161 Query: 662 APLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILIS 721 P E + ++S D TV++W K+ DD+ A + + S D L S Sbjct: 162 HPSEA--LLASSSYDDTVRIW---KDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCS 216 Query: 722 VGLENGEIYLYSYTLG 737 ++ + ++ Y Sbjct: 217 GS-DDSTVRVWKYMGD 231 Score = 48.4 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 20/141 (14%), Positives = 46/141 (32%), Gaps = 12/141 (8%) Query: 3 ECITPEAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALW-----DPIEPNNKGVYATLKG 57 EC+ G + V ++ + T+ +W D + A L Sbjct: 188 ECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPD 247 Query: 58 -HEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSK-TIVALSA--- 112 H+ +V V + + + S D + +++ D + + I + Sbjct: 248 VHKRQVYNVAWGFNG-LIASVGADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVKWLEL 306 Query: 113 -LPSLISVGCADGTISIWRQN 132 ++++ G DG ++ W Sbjct: 307 NGKTILATGGDDGIVNFWSLE 327 Score = 42.6 bits (98), Expect = 7e-04, Method: Composition-based stats. Identities = 52/361 (14%), Positives = 102/361 (28%), Gaps = 64/361 (17%) Query: 345 LWFTHERMDFFLTNGKTGSWRMWATK-DNIICDQRLGISGATKDVTDIAWSPSGEYLLAT 403 +W T ++ + K D+ L + K + +AW P L A Sbjct: 17 IWSFDFSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTSLLAAG 76 Query: 404 SLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVE-TVTDTRFVSGGDEKIL 462 S D T I+ + + H ++ V + + +K + Sbjct: 77 SFDSTVS-----IWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSV 131 Query: 463 RSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDA-----NEDDEEEE 517 ++ +G + + + E ++ P L + DD + DD+ Sbjct: 132 WIWE--TDESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDD--- 186 Query: 518 GGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASAC 577 W V L GH + D + + Sbjct: 187 ------------------------------WECVAVLNGHEGTVWSSDFDKTEGVF---- 212 Query: 578 RSNN-VQNAVIRIFS--------TENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDR 628 R + ++ +R++ + W+ H + + + +G + SV D Sbjct: 213 RLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNG-LIASVGADG 271 Query: 629 KWALWERNMED-NTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKE 687 A++E + F R + I W L + T D V W +K Sbjct: 272 VLAVYEEVDGEWKVFAKRALCHGVYE--INVVKWLELNGKTILATGGDDGIVNFWSLEKA 329 Query: 688 P 688 Sbjct: 330 A 330 >5Y88-O nrPDB Length = 451 Score = 115 bits (288), Expect = 6e-26, Method: Composition-based stats. Identities = 58/305 (19%), Positives = 103/305 (33%), Gaps = 48/305 (15%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 + T+ +WD + TL GH V V ++ S SED VK W Sbjct: 155 FITGSNDTTMKVWDL---ATGKLKTTLAGHVMTVRDVAVSDRHPYLFSVSEDKTVKCWDL 211 Query: 89 TDYSHLQCIQTIQHYSKTIVALSALP--SLISVGCADGTISIWRQNIQNDEFGLAHEFTI 146 Q I+ + + +S P LI+ D I +W + L Sbjct: 212 E---KNQIIRDYYGHLSGVRTVSIHPTLDLIATAGRDSVIKLWDMRTRIPVITLVGHKGP 268 Query: 147 KKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVK 206 C + + T+ V + + + + L H+ V+ Sbjct: 269 ---INQVQCTPVDPQ------VVSSSTDATVRLWDVVA-------GKTMKVLTHHKRSVR 312 Query: 207 SLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKL--TLLSNKQYKFQID 264 + A +E + S D IR W + L+ + E + + TL N+ Sbjct: 313 ATALHPKEFS----VASACTDD-IRSWGLAEGSLLTNFESEKTGIINTLSINQDDVLFAG 367 Query: 265 DELRVGINFEALIMGH-------DDWISSLQ---------WHESRLQLLAATADTSLMVW 308 + V ++ GH + + SL+ + ++ L+L+ AD S+ +W Sbjct: 368 GDNGVLSFYDYK-SGHKYQSLATREMVGSLEGERSVLCSTFDKTGLRLITGEADKSIKIW 426 Query: 309 EPDET 313 + DET Sbjct: 427 KQDET 431 Score = 104 bits (260), Expect = 1e-22, Method: Composition-based stats. Identities = 58/364 (15%), Positives = 121/364 (33%), Gaps = 51/364 (14%) Query: 43 PIEPNNKGVYATLKGHEAEVTCVRFVP-DSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQ 101 P + + GH V CV P D+++ ++ S D +K+W + Sbjct: 123 PEWHAPWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHV 182 Query: 102 HYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKV 161 + + P L SV D T+ W + + ++ +S+ Sbjct: 183 MTVRDVAVSDRHPYLFSV-SEDKTVKCWDLE----KNQIIRDYYGH--LSGVRTVSIHPT 235 Query: 162 EEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLL 221 + L+A G + + + I L GH+ + + Q TP D + Sbjct: 236 LD---LIATAGRDSVIKLWDMRTRIPVI-------TLVGHKGPINQV----QCTPVDPQV 281 Query: 222 CSGSQDRYIRLWRI---RINDLIDDSEEDSKKLTLLSNK-QYKFQIDDELRV-GINFEAL 276 S S D +RLW + + ++ + + L + D++R G+ +L Sbjct: 282 VSSSTDATVRLWDVVAGKTMKVLTHHKRSVRATALHPKEFSVASACTDDIRSWGLAEGSL 341 Query: 277 IMGHDDW----ISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGAS 332 + + I++L ++ + L A + L ++ + R S +G Sbjct: 342 LTNFESEKTGIINTLSINQDDV-LFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEGER 400 Query: 333 TATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIA 392 + C F + +T S ++W + + + +A Sbjct: 401 SVL--------CSTFDKTGLR-LITGEADKSIKIW----------KQDETATKESEPGLA 441 Query: 393 WSPS 396 W+P+ Sbjct: 442 WNPN 445 Score = 66.8 bits (161), Expect = 4e-11, Method: Composition-based stats. Identities = 30/194 (15%), Positives = 64/194 (32%), Gaps = 20/194 (10%) Query: 545 HLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPF 604 H W + GH + C+ I P + + ++++ ++K L Sbjct: 126 HAPWKLSRVINGHLGWVRCVAIDPVDNEWFITGSN----DTTMKVWDLATG-KLKTTLAG 180 Query: 605 HSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPL 664 H +T+ + S +L SV D+ W+ + T I Sbjct: 181 HVMTVRDVAVSDRHPYLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPT----- 235 Query: 665 EFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGL 724 ++ TA RD +K+W + + + H + + + +++ S Sbjct: 236 --LDLIATAGRDSVIKLWDMRTRIP----VITLVGHKGPINQVQCTP--VDPQVVSSST- 286 Query: 725 ENGEIYLYSYTLGK 738 + + L+ GK Sbjct: 287 -DATVRLWDVVAGK 299 Score = 66.5 bits (160), Expect = 4e-11, Method: Composition-based stats. Identities = 49/375 (13%), Positives = 117/375 (31%), Gaps = 82/375 (21%) Query: 332 STATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDI 391 S G+ C+ ++F+T + ++W + + ++G V D+ Sbjct: 132 SRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKL---KTTLAGHVMTVRDV 188 Query: 392 AWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDT 451 A S YL + S D+T + + K +I + + + T+ Sbjct: 189 AVSDRHPYLFSVSEDKTVKCWDL-------EKNQIIRDYYGHLSGVRT--VSIHPTLD-- 237 Query: 452 RFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANE 511 + G + +++ +D+ +PV+ L G Sbjct: 238 LIATAGRDSVIKLWDMRT------------------------RIPVITLVGHKG------ 267 Query: 512 DDEEEEGGNKETPDITDPLSLLECPPME-----DQLQRHLLWPEV------EKLYGHGFE 560 P++ ++C P++ + +V + L H Sbjct: 268 -----------------PINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMKVLTHHKRS 310 Query: 561 ITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKF 620 + + P + +ASAC + IR + + + I L ++D Sbjct: 311 VRATALHPKEFSVASACTDD------IRSWGLAEGSLLTNFESEKTGIINTLSINQD-DV 363 Query: 621 LLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDA--DWAPLEFGNVFVTASRDKT 678 L + + + ++ + ++ E + + + G +T DK+ Sbjct: 364 LFAGGDNGVLSFYDYKSG-HKYQSLATREMVGSLEGERSVLCSTFDKTGLRLITGEADKS 422 Query: 679 VKVWRHQKEPADDYV 693 +K+W+ + + Sbjct: 423 IKIWKQDETATKESE 437 Score = 64.2 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 31/197 (15%), Positives = 60/197 (30%), Gaps = 32/197 (16%) Query: 275 ALIMGHDDWISSLQWHE-SRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGAST 333 +I GH W+ + + + DT++ VW+ K +T Sbjct: 133 RVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATG---------------KLKTT 177 Query: 334 ATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAW 393 G R + + + + + W + N I G V ++ Sbjct: 178 LAGHVMTVRDVAVSD--RHPYLFSVSEDKTVKCWDLEKNQIIR---DYYGHLSGVRTVSI 232 Query: 394 SPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRF 453 P+ + + D +L +D R I + + C T D + Sbjct: 233 HPTLDLIATAGRDSVIKL-----WDMRTRIPVI----TLVGHKGPINQVQC--TPVDPQV 281 Query: 454 VSGGDEKILRSFDLPKG 470 VS + +R +D+ G Sbjct: 282 VSSSTDATVRLWDVVAG 298 Score = 59.5 bits (142), Expect = 5e-09, Method: Composition-based stats. Identities = 65/361 (18%), Positives = 125/361 (34%), Gaps = 65/361 (18%) Query: 429 WH---EFSRP-QIHGYDMICV--ETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQ 482 WH + SR H + CV + V + F++G ++ ++ +DL G L+ + Sbjct: 125 WHAPWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLAT---GKLKTTLAGH 181 Query: 483 FEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQL 542 ++ S P L ED L Sbjct: 182 VMTVRDVAVSDRHPYL---FSVSEDKT---------------------------VKCWDL 211 Query: 543 QRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPAL 602 +++ + + YGH + + I P LIA+A R ++VI+++ + + L Sbjct: 212 EKNQI---IRDYYGHLSGVRTVSIHPTLDLIATAGR-----DSVIKLWDMRTRIPV-ITL 262 Query: 603 PFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWA 662 H I +++ + ++S D LW+ K H R + Sbjct: 263 VGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGK-----TMKVLTHHKRSVRATALH 317 Query: 663 PLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISV 722 P EF V + D ++ W + + + + ++ I+ I + ++ Sbjct: 318 PKEFS-VASACTDD--IRSWGLAE--------GSLLTNFESEKTGIINTLSINQDDVLFA 366 Query: 723 GLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRI 782 G +NG + Y Y G E + + + S + G L L G +D S +I Sbjct: 367 GGDNGVLSFYDYKSGHKYQSLATREMVGSLEGERSVLCSTFDKTG-LRLITGEADKSIKI 425 Query: 783 Y 783 + Sbjct: 426 W 426 >5WYJ-BC nrPDB Length = 817 Score = 115 bits (287), Expect = 7e-26, Method: Composition-based stats. Identities = 124/713 (17%), Positives = 240/713 (33%), Gaps = 111/713 (15%) Query: 5 ITPEAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTC 64 I+ I+ G++ VS+ K + + I + D + K ++ E E+T Sbjct: 10 ISLNPIYAGSSAVATVSE--NGKILATPVLDE-INIIDLTPGSRKILHKISNEDEQEITA 66 Query: 65 VRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADG 124 ++ PD ++ S+ +KI+ ++ ++ I+ + +L++VG DG Sbjct: 67 LKLTPDGQYLTYVSQAQLLKIFHLKTGKVVRSMKI--SSPSYILDADSTSTLLAVGGTDG 124 Query: 125 TISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFIL 184 +I + +I+N H F G L ++ K +LLA G TN V + + Sbjct: 125 SIIV--VDIENGYIT--HSFKGHGGTISSLKF-YGQLNSKIWLLASGDTNGMVKVWDLVK 179 Query: 185 SDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYL--LCSGSQDRYIRLWRIRINDLID 242 + + L+ H V+ L + L SG +D I LW + Sbjct: 180 R-------KCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCK 232 Query: 243 D----------------SEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISS 286 + D K++ + FQ+ D + + +I Sbjct: 233 LLKTLPVNQQVESCGFLKDGDGKRIIYTAGGDAIFQLIDSESGSVLKRTNKPIEELFIIG 292 Query: 287 LQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLW 346 + S Q+ +D +L + +E L+ E + + S+ G+ G + + Sbjct: 293 VLPILSNSQMFLVLSDQTLQLINVEED-------LKNDEDTIQVTSSIAGNHG-IIADMR 344 Query: 347 FTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGI-----SGATKDVTDIAWSPSGEYLL 401 + ++ + S R+ D + L + G + + + G ++ Sbjct: 345 YVGPELNKLALATNSPSLRIIPVPDLSGPEASLPLDVEIYEGHEDLLNSLDATEDGLWIA 404 Query: 402 ATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGD--- 458 S D T ++ Y+ + K +I +++ H V V VS G Sbjct: 405 TASKDNTAIVWR---YNENSCKFDI-----YAKYIGHS---AAVTAVGLPNIVSKGYPEF 453 Query: 459 ------EKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANED 512 + ++ + +PK A M D + V + A E D N Sbjct: 454 LLTASNDLTIKKWIIPKPTASM----------------DVQIIKVSEYTRHAHEKDINAL 497 Query: 513 DEEEEGGNKETP--DITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQ 570 T D T + LE +E L H + + Sbjct: 498 SVSPNDSIFATASYDKTCKIWNLENGELEAT------------LANHKRGLWDVSFCQYD 545 Query: 571 KLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKW 630 KL+A++ V+ + FS L H+ + R F K L+S D Sbjct: 546 KLLATSSGDKTVKIWSLDTFSVMK------TLEGHTNAVQRCSFINKQKQLISCGADGLI 599 Query: 631 ALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWR 683 +W+ + + K H +W + + G++ V+A D + W+ Sbjct: 600 KIWDCSSGECL-----KTLDGHNNRLW--ALSTMNDGDMIVSADADGVFQFWK 645 Score = 86.5 bits (212), Expect = 4e-17, Method: Composition-based stats. Identities = 96/695 (13%), Positives = 210/695 (30%), Gaps = 98/695 (14%) Query: 64 CVRFVP---DSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVG 120 + P S + + SE+ + D + I K + +S Sbjct: 9 GISLNPIYAGSSAVATVSENGKILATPVLD--EINIIDLTPGSRKILHKISNEDEQEITA 66 Query: 121 ---CADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEE---KKYLLAIGGTN 174 DG + + + K S S + + LLA+GGT+ Sbjct: 67 LKLTPDGQ---YLTYVSQAQLLKIFHLKTGKVVRSMKISSPSYILDADSTSTLLAVGGTD 123 Query: 175 VNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWR 234 ++ + IE + +GH + SL F Q +LL SG + +++W Sbjct: 124 GSIIVV-------DIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWD 176 Query: 235 IRIND-----------------LIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALI 277 + + ++ L + + D Sbjct: 177 LVKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLLKT 236 Query: 278 MGHDDWISSLQWHESR---LQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTA 334 + + + S + + + A D + + + S + + + E+ G Sbjct: 237 LPVNQQVESCGFLKDGDGKRIIYTAGGDAIFQLIDSESGSVLKRTNKPIEELFIIGVLPI 296 Query: 335 TGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAW- 393 +S F + D I+G + D+ + Sbjct: 297 LSNSQMFLVL--SDQTLQLINVEED--------LKNDEDTIQVTSSIAGNHGIIADMRYV 346 Query: 394 SPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTR- 452 P L + + R+ + D SG + + + + H + ++ D Sbjct: 347 GPELNKLALATNSPSLRIIP--VPDLSGPEASLPL--DVEIYEGHEDLLNSLDATEDGLW 402 Query: 453 FVSGGDEKILRSFDLPKGVA--GMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDAN 510 + + + + + K++G SA V +GL N + Sbjct: 403 IATASKDNTAIVWRYNENSCKFDIYAKYIG----------HSAAVTAVGLPNIVSKG--- 449 Query: 511 EDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQ 570 E + D+T ++ P + ++ + H +I L +SP+ Sbjct: 450 ----YPEFLLTASNDLTIKKWIIPKP--TASMDVQIIKVSEYTRHAHEKDINALSVSPND 503 Query: 571 KLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKW 630 + A+A +I++ EN E++ L H + + F + K L + D+ Sbjct: 504 SIFATASYDKTC-----KIWNLENG-ELEATLANHKRGLWDVSFCQYDKLLATSSGDKTV 557 Query: 631 ALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPAD 690 +W + K + HT + + + ++ D +K+W + + Sbjct: 558 KIWSLDT-----FSVMKTLEGHTNAVQRC--SFINKQKQLISCGADGLIKIW----DCSS 606 Query: 691 DYVLEASIKHTKAVTAISIHDSMIREKILISVGLE 725 L+ H + A+S +M +++S + Sbjct: 607 GECLKTLDGHNNRLWALS---TMNDGDMIVSADAD 638 Score = 69.5 bits (168), Expect = 5e-12, Method: Composition-based stats. Identities = 83/547 (15%), Positives = 167/547 (30%), Gaps = 87/547 (15%) Query: 281 DDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGG 340 + I++L+ L + L ++ + + ST+T Sbjct: 61 EQEITALKLTPDGQYLTYVSQAQLLKIFHLKTGKVVRSMKISSPSYILDADSTST----- 115 Query: 341 FWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAW--SPSGE 398 G GS + ++ I G ++ + + + + Sbjct: 116 -------------LLAVGGTDGSIIVVDIENGYITH---SFKGHGGTISSLKFYGQLNSK 159 Query: 399 --YLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSR--PQIHGYDMICVETVTDTRF- 453 L + + + ++D RK H + G D+I V + Sbjct: 160 IWLLASGDTNGMVK-----VWDLVKRK----CLHTLQEHTSAVRGLDIIEVPDNDEPSLN 210 Query: 454 -VSGGDEKILRSFD--LPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDAN 510 +SGG + I+ +D + K + V Q E + D ++ AG D Sbjct: 211 LLSGGRDDIINLWDFNMKKKCKLLKTLPVNQQVESCGFLKDGDGKRII---YTAGGDAIF 267 Query: 511 EDDEEEEGGN-KETPDITDPLSLLECPPMEDQLQRHLLWPE------------------- 550 + + E G K T + L ++ P+ Q L+ + Sbjct: 268 QLIDSESGSVLKRTNKPIEELFIIGVLPILSNSQMFLVLSDQTLQLINVEEDLKNDEDTI 327 Query: 551 --VEKLYGHGFEITCLD-ISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPA----LP 603 + G+ I + + P+ +A A S ++ +I + P Sbjct: 328 QVTSSIAGNHGIIADMRYVGPELNKLALATNSPSL--RIIPVPDLSGPEASLPLDVEIYE 385 Query: 604 FHSLTITRLKFSKDGKFLLSVCRDRKWALWE--RNMEDNTFELRFKNEKPHTRIIWDADW 661 H + L ++DG ++ + +D +W N ++ + + Sbjct: 386 GHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPNI 445 Query: 662 APLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILIS 721 + +TAS D T+K W K A V + +S + EK + + Sbjct: 446 VSKGYPEFLLTASNDLTIKKWIIPKPTASMDV---------QIIKVSEYTRHAHEKDINA 496 Query: 722 VGLENGEIYLYSYTLGKFELITQLNE---DITPADKITRLRWSHLKRNGKLFLGVGSSDL 778 + + + + + K I L + T A+ R W L S D Sbjct: 497 LSVSPNDSIFATASYDKTCKIWNLENGELEATLANH-KRGLWDVSFCQYDKLLATSSGDK 555 Query: 779 STRIYSL 785 + +I+SL Sbjct: 556 TVKIWSL 562 Score = 62.6 bits (150), Expect = 6e-10, Method: Composition-based stats. Identities = 34/206 (16%), Positives = 72/206 (34%), Gaps = 20/206 (9%) Query: 10 IFIGANKQTQV-SDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFV 68 G Q S I+K K++++ GA I +WD ++ TL GH + + + Sbjct: 570 TLEGHTNAVQRCSFINKQKQLISCGADGLIKIWDC---SSGECLKTLDGHNNRLWALSTM 626 Query: 69 PDSDFMVSASEDHHVKIWKFTDYSHLQC--------IQTIQHYSKTIVALSALPSLISVG 120 D D +VSA D + WK ++ ++ Q + + + Sbjct: 627 NDGDMIVSADADGVFQFWKDCTEQEIEEEQEKAKLQVEQEQSLQNYMSKGDWTNAFLLAM 686 Query: 121 CADGTISIWRQNIQNDEFGLAHEFT----IKKGFFYPLCLSLSKVEEKKYLLAIGGTNVN 176 D + ++ + + + T I+ F L ++S + +++ +L + Sbjct: 687 TLDHPMRLFNVLKRALGESRSRQDTEEGKIEVIFNEELDQAISILNDEQLILLM----KR 742 Query: 177 VFIASFILSDSGIEKCRVVAELEGHE 202 + I + + L H Sbjct: 743 CRDWNTNAKTHTIAQRTIRCILMHHN 768 Score = 38.0 bits (86), Expect = 0.015, Method: Composition-based stats. Identities = 35/217 (16%), Positives = 70/217 (32%), Gaps = 23/217 (10%) Query: 518 GGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKL-----YGHGFEITCLDISPDQKL 572 G+ +++ +L P+ D++ L P K+ EIT L ++PD + Sbjct: 17 AGSSAVATVSENGKIL-ATPVLDEINIIDLTPGSRKILHKISNEDEQEITALKLTPDGQY 75 Query: 573 IASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWAL 632 + Q +++IF + ++ I L D + Sbjct: 76 LTYVS-----QAQLLKIFHLKTGKVVRSMKISSPSYILDA--DSTSTLLAVGGTDGSIIV 128 Query: 633 WERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDY 692 + T + + + + + + + + VKVW K Sbjct: 129 VDIENGYITHSFKGHGGTISSLKFYGQLNSKIW---LLASGDTNGMVKVWDLVKRKC--- 182 Query: 693 VLEASIKHTKAVTA---ISIHDSMIREKILISVGLEN 726 L +HT AV I + D+ L+S G ++ Sbjct: 183 -LHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDD 218 >5WBU-D nrPDB Length = 328 Score = 114 bits (284), Expect = 2e-25, Method: Composition-based stats. Identities = 49/303 (16%), Positives = 94/303 (31%), Gaps = 42/303 (13%) Query: 14 ANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDF 73 + Q ++ + ++A + I ++D NN + G + V F D + Sbjct: 43 QDSQVNALEVTPDRSMIAAAGYQHIRMYDL-NSNNPNPIISYDGVNKNIASVGFHEDGRW 101 Query: 74 MVSASEDHHVKIWKFTDYSHLQCIQTIQHYSK-TIVALSALPSLISVGCADGTISIWRQN 132 M + ED +IW +LQC + Q + V L + + VG G I IW Sbjct: 102 MYTGGEDCTARIWDLRS-RNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLK 160 Query: 133 IQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKC 192 L E + S + Y+ A+ T N ++ + Sbjct: 161 TD-HNEQLIPEPEVS-------ITSAHIDPDASYMAAVNST-GNCYVWNLTGGIGDEVTQ 211 Query: 193 RVVAE-LEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKL 251 + + H + F P LL + S D+ ++WR Sbjct: 212 LIPKTKIPAHTRYALQCRFS----PDSTLLATCSADQTCKIWRTSN-------------- 253 Query: 252 TLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPD 311 + + ++ G E W+ + ++ A++D +W + Sbjct: 254 -------FSLMTELSIKSGNPGE----SSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 302 Query: 312 ETS 314 Sbjct: 303 TGE 305 Score = 87.6 bits (215), Expect = 2e-17, Method: Composition-based stats. Identities = 46/341 (13%), Positives = 109/341 (31%), Gaps = 49/341 (14%) Query: 109 ALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLL 168 + + P +++ D T+ W+ + + H+ + ++ +V + ++ Sbjct: 9 TVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDS---------QVNALEVTPDRSMI 59 Query: 169 AIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDR 228 A G ++ + ++ + +G + S+ F + +G +D Sbjct: 60 AAAGYQ-HIRMYDLNSNNPNP-----IISYDGVNKNIASVGFH----EDGRWMYTGGEDC 109 Query: 229 YIRLWRIRINDLIDDS----EEDSKKLTLLSNKQYKFQIDD-------ELRVGINFEALI 277 R+W +R +L + L N+ D +L+ N E LI Sbjct: 110 TARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHN-EQLI 168 Query: 278 MGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGS 337 + I+S + A + + VW G V + Sbjct: 169 PEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVT-------QLIPKTKIPAH 221 Query: 338 SGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQ---RLGISGATKD--VTDIA 392 + C + + T + ++W T + + + + G G + + A Sbjct: 222 TRYALQCRFSPDSTL--LATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCA 279 Query: 393 WSPSGEYLLATSLDQTTRLFAPWIYDAS----GRKREIATW 429 +S +Y++ S D RL+ + G ++ + Sbjct: 280 FSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCL 320 Score = 87.6 bits (215), Expect = 2e-17, Method: Composition-based stats. Identities = 54/341 (15%), Positives = 113/341 (33%), Gaps = 52/341 (15%) Query: 73 FMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP--SLISVGCADGTISIWR 130 + +A DH V+ W+ C +T+QH + AL P S+I+ I ++ Sbjct: 16 ILATAGYDHTVRFWQAHSGI---CTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYD 71 Query: 131 QNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIE 190 N N ++++ + K S+ E+ +++ GG + I + + Sbjct: 72 LNSNNPNPIISYD-GVNKN-----IASVGFHEDGRWM-YTGGEDCTARIWDLRSRNLQCQ 124 Query: 191 KCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRI---NDLIDDSEED 247 + V + + + L G Q I +W ++ LI + E Sbjct: 125 RIFQVNA------PINCVCLHPNQAE----LIVGDQSGAIHIWDLKTDHNEQLIPEPEVS 174 Query: 248 SKKLTLLSNKQYKFQIDD--------------ELRVGINFEALIMGHDDWISSLQWHESR 293 + + Y ++ + + + I H + ++ Sbjct: 175 ITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDS 234 Query: 294 LQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMD 353 L +AD + +W S + S++ G + S G W C + + Sbjct: 235 TLLATCSADQTCKIWRTSNFSLMTELSIKSG-------NPGESSRGWMWGCAFSGDSQ-- 285 Query: 354 FFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWS 394 + +T R+W + I + G K V +A++ Sbjct: 286 YIVTASSDNLARLWCVETGEI---KREYGGHQKAVVCLAFN 323 Score = 64.9 bits (156), Expect = 1e-10, Method: Composition-based stats. Identities = 40/302 (13%), Positives = 80/302 (26%), Gaps = 56/302 (18%) Query: 216 PGDYLLCSGSQDRYIRLWRIR---INDLIDDSEEDSKKLTLLSNKQYKFQ-------IDD 265 +L + D +R W+ + + L + ++ + D Sbjct: 12 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYD 71 Query: 266 ELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETS----------- 314 N G + I+S+ +HE + D + +W+ + Sbjct: 72 LNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNA 131 Query: 315 -------GIWVCSLRLGEMSSKGA--STATGSSG------GFWSCLWFTHERMDFFLTNG 359 L +G+ S T + + Sbjct: 132 PINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVN 191 Query: 360 KTGSWRMWATKDNIICD-----QRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAP 414 TG+ +W I + + I T+ +SP L S DQT +++ Sbjct: 192 STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW-- 249 Query: 415 WIYDASGRKREIATWHEFS----RPQ--IHGYDMICVETVTDTRFVSGGDEKILRSFDLP 468 R + E S P G+ C + V+ + + R + + Sbjct: 250 -------RTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVE 302 Query: 469 KG 470 G Sbjct: 303 TG 304 Score = 63.4 bits (152), Expect = 4e-10, Method: Composition-based stats. Identities = 17/101 (16%), Positives = 37/101 (36%), Gaps = 14/101 (13%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNKGVYATL--------KGHEAEVTCVRFVPDSDFMVS 76 + A +T +W +N + L + + F DS ++V+ Sbjct: 233 DSTLLATCSADQTCKIW---RTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVT 289 Query: 77 ASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLI 117 AS D+ ++W + + + K +V L+ S++ Sbjct: 290 ASSDNLARLWCVETG---EIKREYGGHQKAVVCLAFNDSVL 327 Score = 56.4 bits (134), Expect = 5e-08, Method: Composition-based stats. Identities = 54/358 (15%), Positives = 108/358 (30%), Gaps = 59/358 (16%) Query: 296 LLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFF 355 L A D ++ W+ +C+ + S+ + + + H Sbjct: 17 LATAGYDHTVRFWQA----HSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH------ 66 Query: 356 LTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPW 415 RM+ N + G K++ + + G ++ D T R Sbjct: 67 --------IRMYDLNSNNPNPI-ISYDGVNKNIASVGFHEDGRWMYTGGEDCTAR----- 112 Query: 416 IYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKGVAGML 475 I+D R + + + P + +C+ V G + +DL Sbjct: 113 IWDLRSRNLQCQRIFQVNAP----INCVCLHPNQAELIV-GDQSGAIHIWDLKTD----- 162 Query: 476 QKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLEC 535 + +P+ P + +++ + DA+ GN ++T + Sbjct: 163 --------HNEQLIPE----PEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIG---- 206 Query: 536 PPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENW 595 D++ + K+ H SPD L+A+ + FS Sbjct: 207 ----DEVTQ---LIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTE 259 Query: 596 LEIKPALPFHSLT--ITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKP 651 L IK P S + FS D +++++ D LW + E + Sbjct: 260 LSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAV 317 Score = 53.4 bits (126), Expect = 3e-07, Method: Composition-based stats. Identities = 34/164 (20%), Positives = 58/164 (35%), Gaps = 19/164 (11%) Query: 558 GFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPA-------LPFHSLTIT 610 IT I PD +A+ + N +++ + + +P H+ Sbjct: 172 EVSITSAHIDPDASYMAAVNSTGNCY-----VWNLTGGIGDEVTQLIPKTKIPAHTRYAL 226 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFK-NEKPHTRIIWDADWAPLEFGNV 669 + +FS D L + D+ +W + EL K + W A Sbjct: 227 QCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQY 286 Query: 670 FVTASRDKTVKVWRHQ-KEPADDYVLEASIKHTKAVTAISIHDS 712 VTAS D ++W + E +Y H KAV ++ +DS Sbjct: 287 IVTASSDNLARLWCVETGEIKREYG-----GHQKAVVCLAFNDS 325 Score = 35.6 bits (80), Expect = 0.077, Method: Composition-based stats. Identities = 21/153 (13%), Positives = 57/153 (37%), Gaps = 13/153 (8%) Query: 552 EKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPAL-PFHSLTIT 610 + ++ L+++PD+ +IA+A + IR++ + + I Sbjct: 38 RTVQHQDSQVNALEVTPDRSMIAAAGYQH------IRMYDLNSNNPNPIISYDGVNKNIA 91 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVF 670 + F +DG+++ + D +W+ + + F+ P + + A Sbjct: 92 SVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQA------EL 145 Query: 671 VTASRDKTVKVWRHQKEPADDYVLEASIKHTKA 703 + + + +W + + + + E + T A Sbjct: 146 IVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSA 178 >3JB9-L nrPDB Length = 340 Score = 110 bits (274), Expect = 3e-24, Method: Composition-based stats. Identities = 51/325 (15%), Positives = 115/325 (35%), Gaps = 46/325 (14%) Query: 7 PEAIFIGANKQTQVSDIH-KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCV 65 P G + V+ + G + I LW+ + Y L G + +T + Sbjct: 42 PNLQMFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVFG--DVKNYGVLNGCKGAITDL 99 Query: 66 RFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSA---LPSLISVGCA 122 ++ DS + +S D H+ W Q I+ + ++ + AL L++ Sbjct: 100 QWSRDSRVVYCSSSDTHLMSWDAVSG---QKIRKHKGHAGVVNALDVLKVGSELLTSVSD 156 Query: 123 DGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASF 182 D T+ +W ++ + ++ + + IGG + + I Sbjct: 157 DCTMKVWDSRSKDCIKTIEEKYPLTAVAIAQQGTQ----------VFIGGIDGAIKIW-- 204 Query: 183 ILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRI----- 237 + L+GH+D + SLA L S S D +R++ ++ Sbjct: 205 -----DLRNNHCSHVLKGHKDIITSLAIS----KDGSSLLSNSMDNTVRIFDVKPFASAQ 255 Query: 238 ------NDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGI-----NFEALIMGHDDWISS 286 I E + + N ++ + V + + ++ GH+ ++ Sbjct: 256 RQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVWSATGDLRYVLPGHEGSVNH 315 Query: 287 LQWHESRLQLLAATADTSLMVWEPD 311 + +H + +L+ ++D ++ + E + Sbjct: 316 VDFHPHQDIILSCSSDRTIFLGELN 340 Score = 101 bits (251), Expect = 1e-21, Method: Composition-based stats. Identities = 52/320 (16%), Positives = 107/320 (33%), Gaps = 41/320 (12%) Query: 102 HYSKTIVALSALPS--LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLS 159 ++ ++ PS + G D I +W +G+ + L S Sbjct: 48 GHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGV-----LNGCKGAITDLQWS 102 Query: 160 KVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDY 219 + ++ ++ ++ + + + + +GH V +L G Sbjct: 103 RDS---RVVYCSSSDTHLMSWDAV-------SGQKIRKHKGHAGVVNALDVLKV---GSE 149 Query: 220 LLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQ----YKFQIDDELRV----GI 271 LL S S D +++W R D I EE + +Q + ID +++ Sbjct: 150 LLTSVSDDCTMKVWDSRSKDCIKTIEEKYPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNN 209 Query: 272 NFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGA 331 + ++ GH D I+SL + LL+ + D ++ +++ + Sbjct: 210 HCSHVLKGHKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQ-------RQLQIFE 262 Query: 332 STATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDI 391 G W + R F + +W+ D R + G V + Sbjct: 263 GAIHGQEHNLLGVAWSRNSR--FVGAGSSDKNVYVWSA----TGDLRYVLPGHEGSVNHV 316 Query: 392 AWSPSGEYLLATSLDQTTRL 411 + P + +L+ S D+T L Sbjct: 317 DFHPHQDIILSCSSDRTIFL 336 Score = 66.8 bits (161), Expect = 3e-11, Method: Composition-based stats. Identities = 45/292 (15%), Positives = 92/292 (31%), Gaps = 61/292 (20%) Query: 530 LSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRI 589 S+L+ L L +++GH E+ P AS + I + Sbjct: 30 GSVLQ---RTSDLNVPNL-----QMFGHTAEVLVARFDPSGSYFASGG-----MDRQILL 76 Query: 590 FSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNE 649 ++ ++ L IT L++S+D + + D W+ + + Sbjct: 77 WNVFGDVKNYGVLNGCKGAITDLQWSRDSRVVYCSSSDTHLMSWDAVSGQ-----KIRKH 131 Query: 650 KPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISI 709 K H ++ D + + + S D T+KVW + + +I+ +TA++I Sbjct: 132 KGHAGVVNALDVLKV-GSELLTSVSDDCTMKVWDSRSK-----DCIKTIEEKYPLTAVAI 185 Query: 710 ---------------------------HDSMIREKILISVGLENGEIYLYSYTLGKFELI 742 H + I+ S+ + L S ++ I Sbjct: 186 AQQGTQVFIGGIDGAIKIWDLRNNHCSHVLKGHKDIITSLAISKDGSSLLSNSMDNTVRI 245 Query: 743 TQLNEDITPADKITRL----------RWSHLKRNGKLFLGVGSSDLSTRIYS 784 + + ++ F+G GSSD + ++S Sbjct: 246 FDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVWS 297 Score = 56.4 bits (134), Expect = 5e-08, Method: Composition-based stats. Identities = 57/331 (17%), Positives = 117/331 (35%), Gaps = 52/331 (15%) Query: 370 KDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATW 429 + + + L + G T +V + PSG Y + +D+ L+ + D Sbjct: 35 RTSDLNVPNLQMFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVF-GDVKNYGVLNGCK 93 Query: 430 HEFSRPQIHGYDMICVETVTDTRFVSGGDEKIL-RSFDLPKGVAGMLQKF--VGIQFEEK 486 + Q + + +DT +S + + + KG AG++ + + E Sbjct: 94 GAITDLQWSRDSRVVYCSSSDTHLMS--WDAVSGQKIRKHKGHAGVVNALDVLKVGSELL 151 Query: 487 SEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQ----- 541 + + D T+ V +K D + EE+ PL+ + Q Sbjct: 152 TSVSDDCTMKVWDSRSK----DCIKTIEEKY-----------PLTAVAIAQQGTQVFIGG 196 Query: 542 LQRHLLWPEVE------KLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENW 595 + + ++ L GH IT L IS D + S N +RIF + + Sbjct: 197 IDGAIKIWDLRNNHCSHVLKGHKDIITSLAISKDGSSLLSNSMDNT-----VRIFDVKPF 251 Query: 596 LEIKPALP-------FHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKN 648 + L + + +S++ +F+ + D+ +W D + L Sbjct: 252 ASAQRQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVWSA-TGDLRYVL---- 306 Query: 649 EKPHTRIIWDADWAPLEFGNVFVTASRDKTV 679 H + D+ P + ++ ++ S D+T+ Sbjct: 307 -PGHEGSVNHVDFHPHQ--DIILSCSSDRTI 334 Score = 54.5 bits (129), Expect = 2e-07, Method: Composition-based stats. Identities = 33/144 (22%), Positives = 50/144 (34%), Gaps = 10/144 (6%) Query: 583 QNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWE-RNMEDNT 641 + I+I+ N L H IT L SKDG LLS D +++ + Sbjct: 197 IDGAIKIWDLRNNHCSHV-LKGHKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQ 255 Query: 642 FELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHT 701 +L+ H + A S DK V VW + YVL H Sbjct: 256 RQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVWSATGDL--RYVLP---GHE 310 Query: 702 KAVTAISIHDSMIREKILISVGLE 725 +V + H + I++S + Sbjct: 311 GSVNHVDFHP---HQDIILSCSSD 331 Score = 48.0 bits (112), Expect = 2e-05, Method: Composition-based stats. Identities = 53/366 (14%), Positives = 104/366 (28%), Gaps = 69/366 (18%) Query: 273 FEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGAS 332 + GH + ++ S + D +++W K Sbjct: 42 PNLQMFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGD--------------VKNYG 87 Query: 333 TATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWA-TKDNIICDQRLGISGATKDVTDI 391 G G W R+ + + W I + G V + Sbjct: 88 VLNGCKGAITDLQWSRDSRVVY--CSSSDTHLMSWDAVSGQKIRKHK----GHAGVVNAL 141 Query: 392 AWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVE-TVTD 450 G LL + D T ++D+ R Y + V Sbjct: 142 DVLKVGSELLTSVSDDCT----MKVWDS----RSKDCIKTIEEK----YPLTAVAIAQQG 189 Query: 451 TRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDAN 510 T+ GG + ++ +DL + K + L +S Sbjct: 190 TQVFIGGIDGAIKIWDLRNNHCSHVLK------------GHKDIITSLAIS--------- 228 Query: 511 EDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQ 570 ++G + + + + + + + P QR L E ++G + + S + Sbjct: 229 -----KDGSSLLSNSMDNTVRIFDVKPFASA-QRQLQIFE-GAIHGQEHNLLGVAWSRNS 281 Query: 571 KLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKW 630 + + + N + ++S L + LP H ++ + F +LS DR Sbjct: 282 RFVGAGSSDKN-----VYVWSATGDL--RYVLPGHEGSVNHVDFHPHQDIILSCSSDRTI 334 Query: 631 ALWERN 636 L E N Sbjct: 335 FLGELN 340 >3JB9-g nrPDB Length = 558 Score = 108 bits (269), Expect = 1e-23, Method: Composition-based stats. Identities = 52/339 (15%), Positives = 104/339 (30%), Gaps = 53/339 (15%) Query: 48 NKGVYATLKGHEAEVTCVRFVP-DSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKT 106 K T KGH ++C+RF P ++S S D+ +KIW+ Y ++T Q +++ Sbjct: 255 PKKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEV--YHDRSLLRTFQGHARP 312 Query: 107 I--VALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEK 164 I ++ S D TI +W + + C+ +K Sbjct: 313 IRDLSFSQDGRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLTN-------CVKFQVDPDK 365 Query: 165 KYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSG 224 G + + I +V + H + S+ F + Sbjct: 366 PNEFLAGTADKRIL-------QFDIRSPDIVQAYDHHLGGINSITF----LENGKRFVTT 414 Query: 225 SQDRYIRLWR----IRINDLIDDSEEDSKKLTLLSNKQY--KFQIDDELRVGINFEALI- 277 S D +R W + I + D + ++ L N + +D+ + V +E Sbjct: 415 SDDSSMRFWEYGTPVPIKFVADIAMHSMPRVALRPNGKSIACQSLDNCIYVYSAYEKYRQ 474 Query: 278 --------MGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSK 329 + + + + + + + W+ + K Sbjct: 475 NKKKVFKGYSCSGYSLEVGFSPDGRFVFSGDSSGNACFWD---------------WKTCK 519 Query: 330 GASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWA 368 + SG S + E ++ GS + W Sbjct: 520 LMAKLPAHSGPVQSMAFHPQETSKVATSSIVDGSIKYWD 558 Score = 102 bits (253), Expect = 7e-22, Method: Composition-based stats. Identities = 42/302 (13%), Positives = 93/302 (30%), Gaps = 38/302 (12%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVK 84 +++ I +W+ ++ + T +GH + + F D +S S D +K Sbjct: 278 SGHLLLSGSMDNQIKIWEVYH--DRSLLRTFQGHARPIRDLSFSQDGRSFLSTSFDKTIK 335 Query: 85 IWKFTDYSHLQCIQTIQHYSKTIVALSAL-PSLISVGCADGTISIWRQNIQNDEFGLAHE 143 +W L C + + + + P+ G AD I + + H Sbjct: 336 LWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGTADKRILQFDIRSPDIVQAYDHH 395 Query: 144 FTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHED 203 S++ +E K + + ++ + + VA++ H Sbjct: 396 LGG--------INSITFLENGKRFVTT-SDDSSMRFWEYGTPVP----IKFVADIAMHSM 442 Query: 204 WVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDS--------EEDSKKLTLLS 255 +L P + S D I ++ + S ++ Sbjct: 443 PRVALR------PNGKSIACQSLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYSLEVGFSP 496 Query: 256 NKQYKFQIDDELRV------GINFEALIMGHDDWISSLQWHESRLQLLAATA--DTSLMV 307 + ++ F D A + H + S+ +H +A ++ D S+ Sbjct: 497 DGRFVFSGDSSGNACFWDWKTCKLMAKLPAHSGPVQSMAFHPQETSKVATSSIVDGSIKY 556 Query: 308 WE 309 W+ Sbjct: 557 WD 558 Score = 96.9 bits (239), Expect = 3e-20, Method: Composition-based stats. Identities = 40/262 (15%), Positives = 83/262 (31%), Gaps = 54/262 (20%) Query: 14 ANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYAT------------------- 54 A +S + ++ KTI LWD + + Sbjct: 310 ARPIRDLSFSQDGRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEF 369 Query: 55 ----------------------LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYS 92 H + + F+ + V+ S+D ++ W++ Sbjct: 370 LAGTADKRILQFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYGTPV 429 Query: 93 HLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFY 152 ++ + I +S VAL I+ D I ++ +++ + K Sbjct: 430 PIKFVADIAMHSMPRVALRPNGKSIACQSLDNCIYVY---SAYEKYRQNKKKVFKGYSCS 486 Query: 153 PLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRH 212 L + + +++ + + F + C+++A+L H V+S+AF Sbjct: 487 GYSLEVGFSPDGRFVFSGDSSGNACF--------WDWKTCKLMAKLPAHSGPVQSMAFHP 538 Query: 213 QETPGDYLLCSGSQDRYIRLWR 234 QET + S D I+ W Sbjct: 539 QET--SKVATSSIVDGSIKYWD 558 Score = 73.8 bits (179), Expect = 3e-13, Method: Composition-based stats. Identities = 38/272 (13%), Positives = 82/272 (30%), Gaps = 61/272 (22%) Query: 193 RVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLT 252 + + +GH + L F +LL SGS D I++W + + + Sbjct: 257 KHIFTWKGHTKGISCLRFFPIS---GHLLLSGSMDNQIKIWEVYHDRSL----------- 302 Query: 253 LLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDE 312 GH I L + + L+ + D ++ +W+ + Sbjct: 303 ---------------------LRTFQGHARPIRDLSFSQDGRSFLSTSFDKTIKLWDTEL 341 Query: 313 TSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWF--THERMDFFLTNGKTGSWRMWATK 370 + +S +C+ F ++ + FL + + Sbjct: 342 GKCLNCF-----------------NSDRLTNCVKFQVDPDKPNEFLAGTADKRILQFDIR 384 Query: 371 DNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWH 430 I + I + +G+ + TS D + R + + H Sbjct: 385 SPDIVQ---AYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYGT-PVPIKFVADIAMH 440 Query: 431 EFSRPQI--HGYDMICVETVTDTRFVSGGDEK 460 R + +G + C +++ + +V EK Sbjct: 441 SMPRVALRPNGKSIAC-QSLDNCIYVYSAYEK 471 Score = 65.7 bits (158), Expect = 7e-11, Method: Composition-based stats. Identities = 33/182 (18%), Positives = 60/182 (32%), Gaps = 19/182 (10%) Query: 555 YGHGFEITCLDISP-DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLK 613 GH I+CL P L+ S N I+I+ + + H+ I L Sbjct: 263 KGHTKGISCLRFFPISGHLLLSGSMDNQ-----IKIWEVYHDRSLLRTFQGHARPIRDLS 317 Query: 614 FSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTA 673 FS+DG+ LS D+ LW+ + + D D N F+ Sbjct: 318 FSQDGRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPD-----KPNEFLAG 372 Query: 674 SRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYS 733 + DK + + + H + +I+ ++ R ++ + + Sbjct: 373 TADKRILQFDIRSPDIVQAYDH----HLGGINSITFLENGKR----FVTTSDDSSMRFWE 424 Query: 734 YT 735 Y Sbjct: 425 YG 426 Score = 61.5 bits (147), Expect = 1e-09, Method: Composition-based stats. Identities = 55/331 (16%), Positives = 104/331 (31%), Gaps = 51/331 (15%) Query: 99 TIQHYSKTIVALSALP---SLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLC 155 T + ++K I L P L+ G D I IW + L F Sbjct: 261 TWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEV---YHDRSLLRTFQGH----ARPI 313 Query: 156 LSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQET 215 LS ++ + L+ + + + L + + + + F+ Sbjct: 314 RDLSFSQDGRSFLST-SFDKTIKLWDTEL-------GKCLNCFNS-DRLTNCVKFQVDPD 364 Query: 216 PGDYLLCSGSQDRYIRLWRIRINDLI---DDSEEDSKKLTLLSNKQYKFQIDDELRV--- 269 + L G+ D+ I + IR D++ D +T L N + D+ + Sbjct: 365 KPNEFLA-GTADKRILQFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFW 423 Query: 270 ------GINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRL 323 I F A I H + + + + + D I+V S Sbjct: 424 EYGTPVPIKFVADIAMHS--MPRVALRPNGKSIACQSLDN-----------CIYVYSAYE 470 Query: 324 GEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISG 383 +K S G+ + F+ + F + +G+ W K C + Sbjct: 471 KYRQNKKKVFKGYSCSGYSLEVGFSPDGR-FVFSGDSSGNACFWDWKT---CKLMAKLPA 526 Query: 384 ATKDVTDIAWSPSGEYLLATSL--DQTTRLF 412 + V +A+ P +ATS D + + + Sbjct: 527 HSGPVQSMAFHPQETSKVATSSIVDGSIKYW 557 Score = 56.8 bits (135), Expect = 3e-08, Method: Composition-based stats. Identities = 68/356 (19%), Positives = 117/356 (32%), Gaps = 63/356 (17%) Query: 333 TATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIA 392 T G + G SCL F L+ ++W + + G + + D++ Sbjct: 261 TWKGHTKGI-SCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLR--TFQGHARPIRDLS 317 Query: 393 WSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTR 452 +S G L+TS D+T + ++D K + F+ ++ CV+ D Sbjct: 318 FSQDGRSFLSTSFDKTIK-----LWDTELGK----CLNCFNSDRL----TNCVKFQVDP- 363 Query: 453 FVSGGDEKILRSFDLPKG-VAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANE 511 D P +AG K + +QF+ +S PD V + G N Sbjct: 364 -------------DKPNEFLAGTADKRI-LQFDIRS--PDI----VQAYDHHLG--GINS 401 Query: 512 DDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQK 571 E G K +D S+ + + V + H L P+ K Sbjct: 402 ITFLENG--KRFVTTSDDSSM-----RFWEYGTPVPIKFVADIAMHSMPRVALR--PNGK 452 Query: 572 LIASACRSNNVQNAVIRIFSTENWL--EIKPALPFHS--LTITRLKFSKDGKFLLSVCRD 627 IA + I ++S K +S + FS DG+F+ S Sbjct: 453 SIA-----CQSLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYSLEVGFSPDGRFVFSGDSS 507 Query: 628 RKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWR 683 W+ +L H+ + + P E V ++ D ++K W Sbjct: 508 GNACFWDWKTCKLMAKL-----PAHSGPVQSMAFHPQETSKVATSSIVDGSIKYWD 558 >6EOJ-D nrPDB Length = 470 Score = 107 bits (267), Expect = 2e-23, Method: Composition-based stats. Identities = 56/298 (18%), Positives = 112/298 (37%), Gaps = 38/298 (12%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVK 84 + +++V +LW+ + + ++ H++ VT +++ DSD+M+S D +K Sbjct: 104 EGRRLVVATYSGEFSLWNASSFTFETL---MQAHDSAVTTMKYSHDSDWMISGDADGMIK 160 Query: 85 IWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQ-NIQNDEFGLAHE 143 IW+ ++S ++ I S +A S+ S D + IW N + + H Sbjct: 161 IWQ-PNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHH 219 Query: 144 FTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHED 203 + +K ++P L+A + V + ++ + + Sbjct: 220 WDVKSCDWHPEM----------GLIASASKDNLVKLW-------DPRSGNCISSILKFKH 262 Query: 204 WVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIR--INDLID-DSEEDSKKLTLLSNKQYK 260 V F+ LL + S+D+ R++ IR + +L+ E D L + Sbjct: 263 TVLKTRFQP---TKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESM 319 Query: 261 FQID---------DELRVGINFEALI-MGHDDWISSLQWHESRLQLLAATADTSLMVW 308 F + D L+ I HD I+SL ++ A D ++ W Sbjct: 320 FTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 Score = 100 bits (249), Expect = 2e-21, Method: Composition-based stats. Identities = 40/256 (15%), Positives = 89/256 (34%), Gaps = 23/256 (8%) Query: 15 NKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFM 74 ++ K V + +W+ + V L GH +V + P+ + Sbjct: 178 ESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERV---LSGHHWDVKSCDWHPEMGLI 234 Query: 75 VSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQ 134 SAS+D+ VK+W + + I +H +L+ D + ++ Sbjct: 235 ASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYS 294 Query: 135 NDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRV 194 E + T + L + E + LA + ++ + + + + Sbjct: 295 MKELMCVRDET------DYMTLEWHPINESMFTLAC--YDGSLKHFDLLQNLNEP----I 342 Query: 195 VAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW-RIRINDLIDDSEEDSKKLTL 253 + H+ + SL++ P ++ + ++DR IR W R R D + + Sbjct: 343 LTIPYAHDKCITSLSYN----PVGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKI 398 Query: 254 LSNKQYKFQIDDELRV 269 + F I++++ Sbjct: 399 ---NGWFFGINNDINA 411 Score = 88.8 bits (218), Expect = 7e-18, Method: Composition-based stats. Identities = 60/383 (15%), Positives = 118/383 (30%), Gaps = 79/383 (20%) Query: 33 GAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYS 92 G + I L + + + +++ P+ +V A+ +W + ++ Sbjct: 73 GRDRVINLPSKFTHLSSNKV------KHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFT 126 Query: 93 HLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQN-DEFGLAHEFTIKKGFF 151 +Q T+ S + G ADG I IW+ N E AH +I+ F Sbjct: 127 FETLMQAHDSAVTTMK-YSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAF 185 Query: 152 YPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFR 211 + K++ + + I +F + L GH VKS + Sbjct: 186 --------SSNDSKFV--TCSDDNILKIWNFS-------NGKQERVLSGHHWDVKSCDWH 228 Query: 212 HQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGI 271 + L+ S S+D ++LW R + I Sbjct: 229 PEMG----LIASASKDNLVKLWDPRSGNCISS---------------------------- 256 Query: 272 NFEALIMGHDDWISSLQWHES-RLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKG 330 I+ + ++ + L+A + D S V++ + +C Sbjct: 257 -----ILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMC----------- 300 Query: 331 ASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTD 390 + + W F L GS + + N+ K +T Sbjct: 301 ----VRDETDYMTLEWHPINESMFTLAC-YDGSLKHFDLLQNLNEPILTIPYAHDKCITS 355 Query: 391 IAWSPSGEYLLATSLDQTTRLFA 413 ++++P G + D+T R + Sbjct: 356 LSYNPVGHIFATAAKDRTIRFWT 378 Score = 65.7 bits (158), Expect = 7e-11, Method: Composition-based stats. Identities = 24/154 (15%), Positives = 56/154 (36%), Gaps = 22/154 (14%) Query: 261 FQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCS 320 F + + FE L+ HD ++++++ +++ AD + +W+P+ + + Sbjct: 117 FSLWNA--SSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEI-- 172 Query: 321 LRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLG 380 + + +++ F+T ++W + Q Sbjct: 173 -------------DAAHTESIRDMAFSSNDSK--FVTCSDDNILKIWNFSNGK---QERV 214 Query: 381 ISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAP 414 +SG DV W P + + S D +L+ P Sbjct: 215 LSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDP 248 Score = 63.0 bits (151), Expect = 5e-10, Method: Composition-based stats. Identities = 47/227 (20%), Positives = 84/227 (37%), Gaps = 29/227 (12%) Query: 561 ITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKF 620 I + +P+ + + A S F+ E + H +T +K+S D + Sbjct: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFET------LMQAHDSAVTTMKYSHDSDW 149 Query: 621 LLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVK 680 ++S D +W+ N F + + + HT I D A + FVT S D +K Sbjct: 150 MISGDADGMIKIWQPN-----FSMVKEIDAAHTESIRD--MAFSSNDSKFVTCSDDNILK 202 Query: 681 VWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKFE 740 +W + H V + H M LI+ ++ + L+ G Sbjct: 203 IWNFSNGKQER----VLSGHHWDVKSCDWHPEMG----LIASASKDNLVKLWDPRSGN-- 252 Query: 741 LITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYSLAY 787 I+ + + K T L+ G L + + S D S R++ + Y Sbjct: 253 CISSILKF-----KHTVLKTRFQPTKGNLLMAI-SKDKSCRVFDIRY 293 Score = 61.8 bits (148), Expect = 9e-10, Method: Composition-based stats. Identities = 27/190 (14%), Positives = 68/190 (35%), Gaps = 31/190 (16%) Query: 281 DDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGG 340 I ++QW +L+ AT +W SS T + Sbjct: 93 KHVIPAIQWTPEGRRLVVATYSGEFSLWNA----------------SSFTFETLMQAHDS 136 Query: 341 FWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYL 400 + + ++H+ D+ ++ G ++W +++ + + T+ + D+A+S + Sbjct: 137 AVTTMKYSHD-SDWMISGDADGMIKIWQPNFSMVKEID---AAHTESIRDMAFSSNDSKF 192 Query: 401 LATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEK 460 + S D +++ ++G++ + + H H C S + Sbjct: 193 VTCSDDNILKIWNF----SNGKQERVLSGH-------HWDVKSCDWHPEMGLIASASKDN 241 Query: 461 ILRSFDLPKG 470 +++ +D G Sbjct: 242 LVKLWDPRSG 251 Score = 55.3 bits (131), Expect = 1e-07, Method: Composition-based stats. Identities = 30/161 (18%), Positives = 67/161 (41%), Gaps = 14/161 (8%) Query: 552 EKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITR 611 L GH +++ D P+ LIASA + N +++++ + I L F T+ + Sbjct: 213 RVLSGHHWDVKSCDWHPEMGLIASASKDN-----LVKLWDPRSGNCISSILKF-KHTVLK 266 Query: 612 LKFSKD-GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVF 670 +F G L+++ +D+ +++ +W P+ ++F Sbjct: 267 TRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCV-----RDETDYMTLEWHPIN-ESMF 320 Query: 671 VTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHD 711 A D ++K + + ++ +L H K +T++S + Sbjct: 321 TLACYDGSLKHFDLLQNL-NEPILTIPYAHDKCITSLSYNP 360 Score = 49.5 bits (116), Expect = 6e-06, Method: Composition-based stats. Identities = 58/384 (15%), Positives = 123/384 (32%), Gaps = 56/384 (14%) Query: 269 VGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSS 328 V + L + +L ++ + P+ G R+ + S Sbjct: 35 VSSPYINLYYNRRHGLPNLVVEPETSY--------TIDIMPPNAYRGRD----RVINLPS 82 Query: 329 KGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDV 388 K ++ + +T E + +G + +W + V Sbjct: 83 KFTHLSSNKVKHVIPAIQWTPEGRRLVVA-TYSGEFSLWNASS---FTFETLMQAHDSAV 138 Query: 389 TDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFS-RPQIHGYDMICVET 447 T + +S +++++ D +++ P EI H S R + Sbjct: 139 TTMKYSHDSDWMISGDADGMIKIWQPNFSMVK----EIDAAHTESIRDMAF--------S 186 Query: 448 VTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGED 507 D++FV+ D+ IL+ ++ G + G ++ KS P +GL A +D Sbjct: 187 SNDSKFVTCSDDNILKIWNFSNGKQERV--LSGHHWDVKS----CDWHPEMGLIASASKD 240 Query: 508 DANEDDEEEEGG--------------NKETPDITDPLSLLECPPMEDQLQRHLLWPEVEK 553 + + + G + P + L + E+ Sbjct: 241 NLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMC 300 Query: 554 LYGHGFEITCLDISP-DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALP-FHSLTITR 611 + +T L+ P ++ + AC ++++ + +N E +P H IT Sbjct: 301 VRDETDYMT-LEWHPINESMFTLACYDGSLKHFDLL----QNLNEPILTIPYAHDKCITS 355 Query: 612 LKFSKDGKFLLSVCRDRKWALWER 635 L ++ G + +DR W R Sbjct: 356 LSYNPVGHIFATAAKDRTIRFWTR 379 >5GAN-H nrPDB Length = 465 Score = 106 bits (264), Expect = 4e-23, Method: Composition-based stats. Identities = 55/366 (15%), Positives = 123/366 (33%), Gaps = 76/366 (20%) Query: 9 AIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFV 68 + + + VS + + + + + L H ++ + + Sbjct: 170 SQLVSTKPISAVSLSTDDMVVATGSWAGDLQV--LNSQTLQPLTQKLDSHVGKIGAIDWH 227 Query: 69 PD-SDFMVSASEDHHVKIWKFTDYSHL-QCIQTIQHYSKTIVALSALPS--LISVGCADG 124 PD ++ M+S +ED +K +++++ + + + + + I + PS I D Sbjct: 228 PDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDM 287 Query: 125 TISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFIL 184 T +W + + L + KG F SLS + + + G ++++ Sbjct: 288 TWRLWDASTHQE---LLLQEGHDKGVF-----SLSFQCDGSLVCSGGMDSLSML------ 333 Query: 185 SDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDS 244 I V L GH + ++A+ P Y + +G D I +W IR D + Sbjct: 334 --WDIRSGSKVMTLAGHSKPIYTVAWS----PNGYQVATGGGDGIINVWDIRKRDEGQLN 387 Query: 245 EEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHES--RLQLLAATAD 302 I+ H + ++ +++ + +L++ D Sbjct: 388 -------------------------------QILAHRNIVTQVRFSKEDGGKKLVSCGYD 416 Query: 303 TSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTG 362 + V+ D W+ L + K S ++ F ++ G Sbjct: 417 NLINVYSSDT----WLKMGSLAGHTDKIISLDISNNSH-------------FLVSGGWDR 459 Query: 363 SWRMWA 368 S ++W Sbjct: 460 SIKLWN 465 Score = 103 bits (255), Expect = 4e-22, Method: Composition-based stats. Identities = 53/358 (14%), Positives = 116/358 (32%), Gaps = 72/358 (20%) Query: 59 EAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS--- 115 ++ V D + + S +++ L Q + + I A+ P Sbjct: 175 TKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLT--QKLDSHVGKIGAIDWHPDSNN 232 Query: 116 LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNV 175 + DG I ++ + + L + + + K++ + Sbjct: 233 QMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERR----ISDVKYHPSGKFIGSASHD-- 286 Query: 176 NVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI 235 ++ L D+ + ++ EGH+ V SL+F+ L+CSG D LW I Sbjct: 287 ----MTWRLWDASTHQELLLQ--EGHDKGVFSLSFQC----DGSLVCSGGMDSLSMLWDI 336 Query: 236 RINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQ 295 R SK +TL GH I ++ W + Q Sbjct: 337 R---------SGSKVMTLA------------------------GHSKPIYTVAWSPNGYQ 363 Query: 296 LLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHE-RMDF 354 + D + VW+ + +G + + + F+ E Sbjct: 364 VATGGGDGIINVWDIRKRD--------------EGQLNQILAHRNIVTQVRFSKEDGGKK 409 Query: 355 FLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLF 412 ++ G ++++ + ++G T + + S + +L++ D++ +L+ Sbjct: 410 LVSCGYDNLINVYSSDTWLKMG---SLAGHTDKIISLDISNNSHFLVSGGWDRSIKLW 464 Score = 93.8 bits (231), Expect = 2e-19, Method: Composition-based stats. Identities = 55/362 (15%), Positives = 111/362 (30%), Gaps = 80/362 (22%) Query: 108 VALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYL 167 V+LS +++ G G + N + + + + + Sbjct: 181 VSLSTDDMVVATGSWAG-----DLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMI 235 Query: 168 LAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQD 227 + + + + G+ R++ +L GHE + + + P + S S D Sbjct: 236 --SCAEDGLIKNFQYSNEEGGL---RLLGDLVGHERRISDVKYH----PSGKFIGSASHD 286 Query: 228 RYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSL 287 RLW + + E GHD + SL Sbjct: 287 MTWRLWDASTHQELLLQE---------------------------------GHDKGVFSL 313 Query: 288 QWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWF 347 + + + D+ M+W+ SG V +L G S ++ W Sbjct: 314 SFQCDGSLVCSGGMDSLSMLWDI--RSGSKVMTLA-------------GHSKPIYTVAWS 358 Query: 348 THERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPS--GEYLLATSL 405 T G G +W + I VT + +S G+ L++ Sbjct: 359 --PNGYQVATGGGDGIINVWDIRKRDEGQLN-QILAHRNIVTQVRFSKEDGGKKLVSCGY 415 Query: 406 DQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRF-VSGGDEKILRS 464 D +++ TW + H +I ++ ++ F VSGG ++ ++ Sbjct: 416 DNLINVYSS------------DTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKL 463 Query: 465 FD 466 ++ Sbjct: 464 WN 465 Score = 72.2 bits (175), Expect = 9e-13, Method: Composition-based stats. Identities = 46/222 (20%), Positives = 75/222 (33%), Gaps = 43/222 (19%) Query: 542 LQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPA 601 L L P +KL H +I +D PD +C + + + + E L + Sbjct: 202 LNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDGLIKNF-QYSNEEGGLRLLGD 260 Query: 602 LPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERN--------------------MEDNT 641 L H I+ +K+ GKF+ S D W LW+ + D + Sbjct: 261 LVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGS 320 Query: 642 FELRFKNE-----------------KPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRH 684 + H++ I+ W+P G T D + VW Sbjct: 321 LVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWSP--NGYQVATGGGDGIINVWDI 378 Query: 685 QKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLEN 726 +K D+ L + H VT + +K L+S G +N Sbjct: 379 RKR--DEGQLNQILAHRNIVTQVRFSKEDGGKK-LVSCGYDN 417 Score = 61.8 bits (148), Expect = 1e-09, Method: Composition-based stats. Identities = 51/310 (16%), Positives = 98/310 (31%), Gaps = 60/310 (19%) Query: 277 IMGHDDWISSLQWHES-RLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTAT 335 + H I ++ WH Q+++ D + ++ G + Sbjct: 214 LDSHVGKIGAIDWHPDSNNQMISCAEDGLIKNFQYSNEEG-----------GLRLLGDLV 262 Query: 336 GSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSP 395 G + H F + +WR+W + + L G K V +++ Sbjct: 263 GHERRISDVKY--HPSGKFIGSASHDMTWRLWDASTH---QELLLQEGHDKGVFSLSFQC 317 Query: 396 SGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVS 455 G + + +D + L+ SG K H S+P + + + Sbjct: 318 DGSLVCSGGMDSLSMLWDIR----SGSKVMTLAGH--SKPIYTVAW-----SPNGYQVAT 366 Query: 456 GGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEE 515 GG + I+ +D+ K G L + +L N + +++D Sbjct: 367 GGGDGIINVWDIRKRDEGQLNQ-------------------ILAHRNIVTQVRFSKED-- 405 Query: 516 EEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIAS 575 GG K D L + W ++ L GH +I LDIS + + S Sbjct: 406 --GGKKLVSCGYDNLI---------NVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVS 454 Query: 576 ACRSNNVQNA 585 +++ Sbjct: 455 GGWDRSIKLW 464 Score = 61.8 bits (148), Expect = 1e-09, Method: Composition-based stats. Identities = 30/173 (17%), Positives = 55/173 (31%), Gaps = 16/173 (9%) Query: 555 YGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKF 614 GH + L D L+ S + IR L HS I + + Sbjct: 304 EGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIR------SGSKVMTLAGHSKPIYTVAW 357 Query: 615 SKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTAS 674 S +G + + D +W+ D E + H I+ ++ + G V+ Sbjct: 358 SPNGYQVATGGGDGIINVWDIRKRD---EGQLNQILAHRNIVTQVRFSKEDGGKKLVSCG 414 Query: 675 RDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENG 727 D + V+ + + HT + ++ D L+S G + Sbjct: 415 YDNLINVYSSD----TWLKMGSLAGHTDKIISL---DISNNSHFLVSGGWDRS 460 Score = 49.9 bits (117), Expect = 5e-06, Method: Composition-based stats. Identities = 32/136 (23%), Positives = 56/136 (41%), Gaps = 13/136 (9%) Query: 550 EVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTI 609 +V L GH I + SP+ +A+ + IR E L A H + Sbjct: 341 KVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIR-KRDEGQLNQILA---HRNIV 396 Query: 610 TRLKFSKD--GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFG 667 T+++FSK+ GK L+S D ++ + L+ + HT I D + Sbjct: 397 TQVRFSKEDGGKKLVSCGYDNLINVYSSDT-----WLKMGSLAGHTDKIISLDIS--NNS 449 Query: 668 NVFVTASRDKTVKVWR 683 + V+ D+++K+W Sbjct: 450 HFLVSGGWDRSIKLWN 465 >1NR0-A nrPDB Length = 611 Score = 104 bits (260), Expect = 1e-22, Method: Composition-based stats. Identities = 77/506 (15%), Positives = 160/506 (31%), Gaps = 76/506 (15%) Query: 6 TPEAIFIGANKQTQVSDIHKVK--KIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVT 63 T G + D + +I++ T+A++ E +T H V Sbjct: 138 TSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIF---EGPPFKFKSTFGEHTKFVH 194 Query: 64 CVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQT----IQHYSKTIVALSALPSL--I 117 VR+ PD S D + ++ D + + +S ++ L+ P I Sbjct: 195 SVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKI 254 Query: 118 SVGCADGTISIWRQNIQNDEFGL---AHEFTIKKGFFYPLCLSLSKVEEKKYLLA---IG 171 + AD TI IW E + + G + +S +G Sbjct: 255 ASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELG 314 Query: 172 GTNVNVFIASFILSD-SGIEKCRVV--AELEGH-EDWVKSLAFRHQETPGDYL------- 220 + + + ++ S + + A+ EGH W S ++ P + Sbjct: 315 SIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIK 374 Query: 221 ------LCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFE 274 L + S D ++++ + DS + D ++ V ++ Sbjct: 375 TTSKGDLFTVSWDDHLKV--VPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYK 432 Query: 275 AL-IMGHDDWI--------SSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGE 325 + I H S + + + D+ + V++ SG V ++ Sbjct: 433 HIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKL---SGASVSEVKTIV 489 Query: 326 MSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGAT 385 ++ S A ++G F + + + + + N + T Sbjct: 490 HPAEITSVAFSNNGAFLVATDQSRKVIPYSVAN-----------NFELAHTNSWTF--HT 536 Query: 386 KDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICV 445 V ++WSP L SLD + +++ + H H M V Sbjct: 537 AKVACVSWSPDNVRLATGSLDNSV-----IVWNMNKPSD-----HPIIIKGAHA--MSSV 584 Query: 446 ET---VTDTRFVSGGDEKILRSFDLP 468 + + +T VS G + ++ +++P Sbjct: 585 NSVIWLNETTIVSAGQDSNIKFWNVP 610 Score = 104 bits (258), Expect = 2e-22, Method: Composition-based stats. Identities = 112/698 (16%), Positives = 217/698 (31%), Gaps = 141/698 (20%) Query: 43 PIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQH 102 P+ T H+ V P + S +V+IW T + TI Sbjct: 45 PVGSLTDTEIYTEHSHQTTVAKT--SPSGYYCASGDVHGNVRIWD-TTQTTHILKTTIPV 101 Query: 103 YSKTIVALSALPS---LISVGCAD---GTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCL 156 +S + +S + +VG G + ++ N + F P Sbjct: 102 FSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLT-GQARAMNSVDFKPS-- 158 Query: 157 SLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETP 216 + + + G + V I + + H +V S+ + P Sbjct: 159 -------RPFRIISGSDDNTVAIFEGPPF-------KFKSTFGEHTKFVHSVRYN----P 200 Query: 217 GDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEAL 276 L S D I L+ E+DS Sbjct: 201 DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDS--------------------------LK 234 Query: 277 IMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATG 336 + H + L W ++ +A+AD ++ +W V +L++ + G Sbjct: 235 NVAHSGSVFGLTWSPDGTKIASASADKTIKIWN--------VATLKVEKTIPVGTRIEDQ 286 Query: 337 SSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPS 396 G W+ ++ G + I R G K +T ++ S Sbjct: 287 QLGIIWT--------KQALVSISANGFINFVNPELGSIDQVRY---GHNKAITALSSSAD 335 Query: 397 GEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSG 456 G+ L + + + ++G + P +H + ++T + + Sbjct: 336 GKTLFSADAEGHINSWDI----STGISNRVF-------PDVHATMITGIKTTSKGDLFTV 384 Query: 457 GDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEE 516 + L+ +P G +G+ + + + + LGL+ A D A Sbjct: 385 SWDDHLKV--VPAGGSGV---------DSSKAVANKLSSQPLGLAVSADGDIA------- 426 Query: 517 EGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASA 576 + I L E P + +C+ +S D++ +A Sbjct: 427 VAACYKHIAIYSHGKLTEVPISYNS--------------------SCVALSNDKQFVAVG 466 Query: 577 CRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERN 636 Q++ + ++ + H IT + FS +G FL++ + RK + Sbjct: 467 G-----QDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPY--- 518 Query: 637 MEDNTFELRFKNE-KPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLE 695 N FEL N HT + W+P T S D +V VW K P+D ++ Sbjct: 519 SVANNFELAHTNSWTFHTAKVACVSWSPDNV--RLATGSLDNSVIVWNMNK-PSDHPIII 575 Query: 696 ASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYS 733 +V ++ + E ++S G ++ I ++ Sbjct: 576 KGAHAMSSVNSVIW----LNETTIVSAG-QDSNIKFWN 608 >5YZG-W nrPDB Length = 579 Score = 103 bits (256), Expect = 3e-22, Method: Composition-based stats. Identities = 57/378 (15%), Positives = 112/378 (29%), Gaps = 83/378 (21%) Query: 3 ECITPE-AIFIGANKQTQVSDIH----KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKG 57 +C P+ I + + VS + +++ I LW+ + T G Sbjct: 273 KCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYG--ERRCLRTFIG 330 Query: 58 HEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS-- 115 H V + F +SA+ D ++K+W QCI K + P Sbjct: 331 HSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETG---QCISRFT-NRKVPYCVKFNPDED 386 Query: 116 ---LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGG 172 L G +D I W + E+ G ++ V+E + ++ Sbjct: 387 KQNLFVAGMSDKKIVQWDIRSGE----IVQEYDRHLGAVN----TIVFVDENRRFVST-S 437 Query: 173 TNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRL 232 + ++ + + + + +AE H +L+ P L S D I + Sbjct: 438 DDKSLRVWEWDIPV----DFKYIAEPSMHSMPAVTLS------PNGKWLACQSMDNQILI 487 Query: 233 WRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGH--DDWISSLQWH 290 + + R +N + + GH + + + Sbjct: 488 FGAQN------------------------------RFRLNKKKIFKGHMVAGYACQVDFS 517 Query: 291 ESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHE 350 +++ + L +W+ T K S +W HE Sbjct: 518 PDMSYVISGDGNGKLNIWDWKTT---------------KLYSRFKAHDKVCIGAVWHPHE 562 Query: 351 RMDFFLTNGKTGSWRMWA 368 +T G G ++W Sbjct: 563 TSK-VITCGWDGLIKLWD 579 Score = 91.5 bits (225), Expect = 1e-18, Method: Composition-based stats. Identities = 49/380 (12%), Positives = 113/380 (29%), Gaps = 91/380 (23%) Query: 97 IQTIQHYSKTIVALSALP---SLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYP 153 I ++K + A+ P L+ D I +W E F Sbjct: 281 IHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEV---YGERRCLRTFIGHSKAVRD 337 Query: 154 LCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQ 213 +C + GT L E + ++ V + Sbjct: 338 ICFN------------TAGTQFLSAAYDRYLKLWDTETGQCISRFT--NRKVPYCVKFNP 383 Query: 214 ETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINF 273 + L +G D+ I W IR +++ + + Sbjct: 384 DEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDR--------------------------- 416 Query: 274 EALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPD-ETSGIWVCSLRLGEMSSKGAS 332 H ++++ + + + ++ + D SL VWE D ++ + M + Sbjct: 417 ------HLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMP----A 466 Query: 333 TATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVT--D 390 +G + +C ++ + F N +++ G Sbjct: 467 VTLSPNGKWLACQSMDNQILIFGAQN-------------RFRLNKKKIFKGHMVAGYACQ 513 Query: 391 IAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTD 450 + +SP Y+++ + ++ + T +SR + H D +C+ V Sbjct: 514 VDFSPDMSYVISGDGNGKLNIW------------DWKTTKLYSRFKAH--DKVCIGAVWH 559 Query: 451 T----RFVSGGDEKILRSFD 466 + ++ G + +++ +D Sbjct: 560 PHETSKVITCGWDGLIKLWD 579 Score = 73.0 bits (177), Expect = 5e-13, Method: Composition-based stats. Identities = 39/273 (14%), Positives = 83/273 (30%), Gaps = 61/273 (22%) Query: 193 RVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLT 252 + + GH V ++ +LL S S D I+LW + Sbjct: 279 KQIHVWSGHTKGVSAVRLFPLS---GHLLLSCSMDCKIKLWEVY---------------- 319 Query: 253 LLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDE 312 ++ +GH + + ++ + Q L+A D L +W+ + Sbjct: 320 --GERRCL--------------RTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTET 363 Query: 313 TSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDN 372 I + R K ++ + F+ W + Sbjct: 364 GQCISRFTNRKVPYCVKFNP---------------DEDKQNLFVAGMSDKKIVQWDIRSG 408 Query: 373 IICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEF 432 I + V I + ++TS D++ R++ +D + IA Sbjct: 409 EIVQE---YDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWE---WDIPVDFKYIAEPSMH 462 Query: 433 SRPQI----HGYDMICVETVTDTRFVSGGDEKI 461 S P + +G + C +++ + + G + Sbjct: 463 SMPAVTLSPNGKWLAC-QSMDNQILIFGAQNRF 494 Score = 61.8 bits (148), Expect = 1e-09, Method: Composition-based stats. Identities = 62/356 (17%), Positives = 119/356 (33%), Gaps = 70/356 (19%) Query: 336 GSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSP 395 G + G + F L+ ++W C + G +K V DI ++ Sbjct: 286 GHTKGVSAVRLFPLSGHL-LLSCSMDCKIKLWEVYGERRCLR--TFIGHSKAVRDICFNT 342 Query: 396 SGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTD----T 451 +G L+ + D+ +L+ F+ ++ CV+ D Sbjct: 343 AGTQFLSAAYDRYLKLW---------DTETGQCISRFTNRKVP----YCVKFNPDEDKQN 389 Query: 452 RFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANE 511 FV+G +K + +D+ G I E + T+ + Sbjct: 390 LFVAGMSDKKIVQWDIRSG---------EIVQEYDRHLGAVNTIVFV------------- 427 Query: 512 DDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQK 571 DE N+ +D SL + + + + + H + + +SP+ K Sbjct: 428 -DE-----NRRFVSTSDDKSL-----RVWEWDIPVDFKYIAEPSMH--SMPAVTLSPNGK 474 Query: 572 LIASACRSNNVQNAVIRIFSTENW--LEIKPALPFH--SLTITRLKFSKDGKFLLSVCRD 627 +A + I IF +N L K H + ++ FS D +++S + Sbjct: 475 WLA-----CQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGN 529 Query: 628 RKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWR 683 K +W+ + K H ++ A W P E + +T D +K+W Sbjct: 530 GKLNIWDWKT-----TKLYSRFKAHDKVCIGAVWHPHE-TSKVITCGWDGLIKLWD 579 Score = 59.9 bits (143), Expect = 4e-09, Method: Composition-based stats. Identities = 34/168 (20%), Positives = 57/168 (33%), Gaps = 17/168 (10%) Query: 550 EVEKLYGHGFEITCLDISP-DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLT 608 ++ GH ++ + + P L+ S I+++ HS Sbjct: 280 QIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCK-----IKLWEVYGERRCLRTFIGHSKA 334 Query: 609 ITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGN 668 + + F+ G LS DR LW+ RF N K + ++ + N Sbjct: 335 VRDICFNTAGTQFLSAAYDRYLKLWDTETGQCIS--RFTNRKVPYCVKFN---PDEDKQN 389 Query: 669 VFVTASRDKTVKVWRHQ-KEPADDYVLEASIKHTKAVTAISIHDSMIR 715 +FV DK + W + E +Y +H AV I D R Sbjct: 390 LFVAGMSDKKIVQWDIRSGEIVQEYD-----RHLGAVNTIVFVDENRR 432 Score = 39.9 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 50/310 (16%), Positives = 104/310 (33%), Gaps = 66/310 (21%) Query: 382 SGATKDVTDIAWSP-SGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGY 440 SG TK V+ + P SG LL+ S+D +L ++ G +R F Sbjct: 285 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKL-----WEVYGERR---CLRTFIGHSKAVR 336 Query: 441 DMICVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVG------IQFEEKSEMPDSAT 494 D IC T T+F+S ++ L+ +D G + +F ++F D Sbjct: 337 D-ICFNTA-GTQFLSAAYDRYLKLWDTETGQC--ISRFTNRKVPYCVKFNPDE---DKQN 389 Query: 495 VPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKL 554 + V G+S+K +++ ++ V++ Sbjct: 390 LFVAGMSDK---------------------------KIVQWDIRSGEI--------VQEY 414 Query: 555 YGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKF 614 H + + + + S + +R++ + ++ K ++ + Sbjct: 415 DRHLGAVNTIVFVDENRRFVSTS-----DDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTL 469 Query: 615 SKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNE-KPHTRIIWDADWAPLEFGNVFVTA 673 S +GK+L D + ++ N F L K K H + + ++ Sbjct: 470 SPNGKWLACQSMDNQILIFGAQ---NRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISG 526 Query: 674 SRDKTVKVWR 683 + + +W Sbjct: 527 DGNGKLNIWD 536 >6QDV-o nrPDB Length = 513 Score = 103 bits (256), Expect = 3e-22, Method: Composition-based stats. Identities = 57/378 (15%), Positives = 112/378 (29%), Gaps = 83/378 (21%) Query: 3 ECITPE-AIFIGANKQTQVSDIH----KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKG 57 +C P+ I + + VS + +++ I LW+ + T G Sbjct: 207 KCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYG--ERRCLRTFIG 264 Query: 58 HEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS-- 115 H V + F +SA+ D ++K+W QCI K + P Sbjct: 265 HSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETG---QCISRFT-NRKVPYCVKFNPDED 320 Query: 116 ---LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGG 172 L G +D I W + E+ G ++ V+E + ++ Sbjct: 321 KQNLFVAGMSDKKIVQWDIRSGE----IVQEYDRHLGAVN----TIVFVDENRRFVST-S 371 Query: 173 TNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRL 232 + ++ + + + + +AE H +L+ P L S D I + Sbjct: 372 DDKSLRVWEWDIPV----DFKYIAEPSMHSMPAVTLS------PNGKWLACQSMDNQILI 421 Query: 233 WRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGH--DDWISSLQWH 290 + + R +N + + GH + + + Sbjct: 422 FGAQN------------------------------RFRLNKKKIFKGHMVAGYACQVDFS 451 Query: 291 ESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHE 350 +++ + L +W+ T K S +W HE Sbjct: 452 PDMSYVISGDGNGKLNIWDWKTT---------------KLYSRFKAHDKVCIGAVWHPHE 496 Query: 351 RMDFFLTNGKTGSWRMWA 368 +T G G ++W Sbjct: 497 TSK-VITCGWDGLIKLWD 513 Score = 91.5 bits (225), Expect = 1e-18, Method: Composition-based stats. Identities = 49/380 (12%), Positives = 113/380 (29%), Gaps = 91/380 (23%) Query: 97 IQTIQHYSKTIVALSALP---SLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYP 153 I ++K + A+ P L+ D I +W E F Sbjct: 215 IHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEV---YGERRCLRTFIGHSKAVRD 271 Query: 154 LCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQ 213 +C + GT L E + ++ V + Sbjct: 272 ICFN------------TAGTQFLSAAYDRYLKLWDTETGQCISRFT--NRKVPYCVKFNP 317 Query: 214 ETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINF 273 + L +G D+ I W IR +++ + + Sbjct: 318 DEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDR--------------------------- 350 Query: 274 EALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPD-ETSGIWVCSLRLGEMSSKGAS 332 H ++++ + + + ++ + D SL VWE D ++ + M + Sbjct: 351 ------HLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMP----A 400 Query: 333 TATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVT--D 390 +G + +C ++ + F N +++ G Sbjct: 401 VTLSPNGKWLACQSMDNQILIFGAQN-------------RFRLNKKKIFKGHMVAGYACQ 447 Query: 391 IAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTD 450 + +SP Y+++ + ++ + T +SR + H D +C+ V Sbjct: 448 VDFSPDMSYVISGDGNGKLNIW------------DWKTTKLYSRFKAH--DKVCIGAVWH 493 Query: 451 T----RFVSGGDEKILRSFD 466 + ++ G + +++ +D Sbjct: 494 PHETSKVITCGWDGLIKLWD 513 Score = 73.0 bits (177), Expect = 5e-13, Method: Composition-based stats. Identities = 39/273 (14%), Positives = 83/273 (30%), Gaps = 61/273 (22%) Query: 193 RVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLT 252 + + GH V ++ +LL S S D I+LW + Sbjct: 213 KQIHVWSGHTKGVSAVRLFPLS---GHLLLSCSMDCKIKLWEVY---------------- 253 Query: 253 LLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDE 312 ++ +GH + + ++ + Q L+A D L +W+ + Sbjct: 254 --GERRCL--------------RTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTET 297 Query: 313 TSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDN 372 I + R K ++ + F+ W + Sbjct: 298 GQCISRFTNRKVPYCVKFNP---------------DEDKQNLFVAGMSDKKIVQWDIRSG 342 Query: 373 IICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEF 432 I + V I + ++TS D++ R++ +D + IA Sbjct: 343 EIVQE---YDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWE---WDIPVDFKYIAEPSMH 396 Query: 433 SRPQI----HGYDMICVETVTDTRFVSGGDEKI 461 S P + +G + C +++ + + G + Sbjct: 397 SMPAVTLSPNGKWLAC-QSMDNQILIFGAQNRF 428 Score = 61.8 bits (148), Expect = 1e-09, Method: Composition-based stats. Identities = 62/356 (17%), Positives = 119/356 (33%), Gaps = 70/356 (19%) Query: 336 GSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSP 395 G + G + F L+ ++W C + G +K V DI ++ Sbjct: 220 GHTKGVSAVRLFPLSGHL-LLSCSMDCKIKLWEVYGERRCLR--TFIGHSKAVRDICFNT 276 Query: 396 SGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTD----T 451 +G L+ + D+ +L+ F+ ++ CV+ D Sbjct: 277 AGTQFLSAAYDRYLKLW---------DTETGQCISRFTNRKVP----YCVKFNPDEDKQN 323 Query: 452 RFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANE 511 FV+G +K + +D+ G I E + T+ + Sbjct: 324 LFVAGMSDKKIVQWDIRSG---------EIVQEYDRHLGAVNTIVFV------------- 361 Query: 512 DDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQK 571 DE N+ +D SL + + + + + H + + +SP+ K Sbjct: 362 -DE-----NRRFVSTSDDKSL-----RVWEWDIPVDFKYIAEPSMH--SMPAVTLSPNGK 408 Query: 572 LIASACRSNNVQNAVIRIFSTENW--LEIKPALPFH--SLTITRLKFSKDGKFLLSVCRD 627 +A + I IF +N L K H + ++ FS D +++S + Sbjct: 409 WLA-----CQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGN 463 Query: 628 RKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWR 683 K +W+ + K H ++ A W P E + +T D +K+W Sbjct: 464 GKLNIWDWKT-----TKLYSRFKAHDKVCIGAVWHPHE-TSKVITCGWDGLIKLWD 513 Score = 59.9 bits (143), Expect = 4e-09, Method: Composition-based stats. Identities = 34/168 (20%), Positives = 57/168 (33%), Gaps = 17/168 (10%) Query: 550 EVEKLYGHGFEITCLDISP-DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLT 608 ++ GH ++ + + P L+ S I+++ HS Sbjct: 214 QIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCK-----IKLWEVYGERRCLRTFIGHSKA 268 Query: 609 ITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGN 668 + + F+ G LS DR LW+ RF N K + ++ + N Sbjct: 269 VRDICFNTAGTQFLSAAYDRYLKLWDTETGQCIS--RFTNRKVPYCVKFN---PDEDKQN 323 Query: 669 VFVTASRDKTVKVWRHQ-KEPADDYVLEASIKHTKAVTAISIHDSMIR 715 +FV DK + W + E +Y +H AV I D R Sbjct: 324 LFVAGMSDKKIVQWDIRSGEIVQEYD-----RHLGAVNTIVFVDENRR 366 Score = 39.9 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 50/310 (16%), Positives = 104/310 (33%), Gaps = 66/310 (21%) Query: 382 SGATKDVTDIAWSP-SGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGY 440 SG TK V+ + P SG LL+ S+D +L ++ G +R F Sbjct: 219 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKL-----WEVYGERR---CLRTFIGHSKAVR 270 Query: 441 DMICVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVG------IQFEEKSEMPDSAT 494 D IC T T+F+S ++ L+ +D G + +F ++F D Sbjct: 271 D-ICFNTA-GTQFLSAAYDRYLKLWDTETGQC--ISRFTNRKVPYCVKFNPDE---DKQN 323 Query: 495 VPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKL 554 + V G+S+K +++ ++ V++ Sbjct: 324 LFVAGMSDK---------------------------KIVQWDIRSGEI--------VQEY 348 Query: 555 YGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKF 614 H + + + + S + +R++ + ++ K ++ + Sbjct: 349 DRHLGAVNTIVFVDENRRFVSTS-----DDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTL 403 Query: 615 SKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNE-KPHTRIIWDADWAPLEFGNVFVTA 673 S +GK+L D + ++ N F L K K H + + ++ Sbjct: 404 SPNGKWLACQSMDNQILIFGAQ---NRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISG 460 Query: 674 SRDKTVKVWR 683 + + +W Sbjct: 461 DGNGKLNIWD 470 >5A9Q-7 nrPDB Length = 360 Score = 101 bits (252), Expect = 9e-22, Method: Composition-based stats. Identities = 51/357 (14%), Positives = 115/357 (32%), Gaps = 49/357 (13%) Query: 9 AIFIGANKQTQVSDIH---KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCV 65 A I A+ + + D+ +++ + +++ +WD E + A+ K H V V Sbjct: 4 ARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRV 63 Query: 66 RFVPD--SDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSK------------TIVALS 111 + + S S D +W+ ++ H+ K + Sbjct: 64 TWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAP 123 Query: 112 AL-PSLISVGCADGTISIWR--QNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEE--KKY 166 +++ ADG + I+ + ++ L HE C+S + Sbjct: 124 KHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEI---SCKLSCSCISWNPSSSRAHSP 180 Query: 167 LLAIGGTN---VNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCS 223 ++A+G + + + K L D V +AF ++L Sbjct: 181 MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAI 240 Query: 224 GSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDW 283 ++D +R+ TL ++ + I+ A H+ Sbjct: 241 ATKD--VRI------------------FTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQ 280 Query: 284 ISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGG 340 + + W+ + L ++ D + +W+ + W C+ L S ++ + Sbjct: 281 VWRVSWNITGTVLASSGDDGCVRLWKANYMDN-WKCTGILKGNGSPVNGSSQQGTSN 336 Score = 52.2 bits (123), Expect = 9e-07, Method: Composition-based stats. Identities = 37/188 (19%), Positives = 63/188 (33%), Gaps = 21/188 (11%) Query: 605 HSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPL 664 H I + F G+ + + D+ +W++ E + K H+ +W WA Sbjct: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDK-SESGDWHCTASW-KTHSGSVWRVTWAHP 68 Query: 665 EFGNVFVTASRDKTVKVW-RHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVG 723 EFG V + S D+T VW E D + V ++ DS + Sbjct: 69 EFGQVLASCSFDRTAAVWEEIVGESNDK-----LRGQSHWVKRTTLVDSRTSVTDVKFAP 123 Query: 724 LENGEIYLYSYTLGKFELI-----------TQLNEDITPADKITRLRWSHLKRNG-KLFL 771 G + L + + I L +I+ + + W+ + Sbjct: 124 KHMG-LMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMI 182 Query: 772 GVGSSDLS 779 VGS D S Sbjct: 183 AVGSDDSS 190 Score = 51.4 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 41/315 (13%), Positives = 97/315 (30%), Gaps = 37/315 (11%) Query: 108 VALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYL 167 V+ ++ +D ++ +W ++ ++ + G + + + E + Sbjct: 18 VSFDFHGRRMATCSSDQSVKVWD-KSESGDWHCTASWKTHSGSVWRVTWA---HPEFGQV 73 Query: 168 LAIGGTNVNVFIASFILSDSGIE-----KCRVVAELEGHEDWVKSLAFRHQETPGDYLLC 222 LA + + I+ +S + L V + F + +L Sbjct: 74 LASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHM--GLMLA 131 Query: 223 SGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQ--YKFQIDDELRVGINFEALIMGH 280 + S D +R++ + D L + + + + + +G Sbjct: 132 TCSADGIVRIY-----EAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGS 186 Query: 281 DDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSS-- 338 DD + A + ++E +E + + + L ++ A + Sbjct: 187 DDS--------------SPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLG 232 Query: 339 GGFWSCLWFTHERMDFFLT-NGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSG 397 F T + F L K + TK I + V ++W+ +G Sbjct: 233 RSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFD--NHNSQVWRVSWNITG 290 Query: 398 EYLLATSLDQTTRLF 412 L ++ D RL+ Sbjct: 291 TVLASSGDDGCVRLW 305 Score = 45.7 bits (106), Expect = 9e-05, Method: Composition-based stats. Identities = 42/313 (13%), Positives = 85/313 (27%), Gaps = 41/313 (13%) Query: 164 KKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCS 223 +A ++ +V + S A + H V + + H E +L S Sbjct: 23 HGRRMATCSSDQSVKVWDK----SESGDWHCTASWKTHSGSVWRVTWAHPEF--GQVLAS 76 Query: 224 GSQDRYIRLWRIRINDLIDD-SEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDD 282 S DR +W + + D + D + L D Sbjct: 77 CSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSAD 136 Query: 283 WISSLQWHESRLQL--------LAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTA 334 I + + L ++ S + W P + M + G+ + Sbjct: 137 GIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHS-------PMIAVGSDDS 189 Query: 335 TGSSGGFWSCLWFTHERMDFF-LTNGKTGSWRMWATKDNIICDQRLGISG-ATKDVTDIA 392 + ++ + + T + + + I ATKDV Sbjct: 190 SPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFT 249 Query: 393 WSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTR 452 P + L ++ + +D + +W+ +T T Sbjct: 250 LKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWN-----------------ITGTV 292 Query: 453 FVSGGDEKILRSF 465 S GD+ +R + Sbjct: 293 LASSGDDGCVRLW 305 Score = 31.8 bits (70), Expect = 1.3, Method: Composition-based stats. Identities = 52/324 (16%), Positives = 106/324 (32%), Gaps = 29/324 (8%) Query: 331 ASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTD 390 A + + F T S ++W ++ + V Sbjct: 4 ARSIAADHKDLIHDVSFDFHGRR-MATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWR 62 Query: 391 IAWS-PS-GEYLLATSLDQTTRLFAPWIYDASGRKREIATW---HEFSRPQIHGYDMICV 445 + W+ P G+ L + S D+T ++ + +++ + R + W + D+ Sbjct: 63 VTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFA 122 Query: 446 ETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEK------SEMPDS--ATVPV 497 + + I+R ++ P V + Q + + K S P S A P+ Sbjct: 123 PKHMGLMLATCSADGIVRIYEAPD-VMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPM 181 Query: 498 LGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECP-PMEDQLQRHLLWPEVEKLYG 556 + + + +A + E N+ T +L+ P+ D L L Sbjct: 182 IAVGSDDSSPNAMAKVQIFEY-NENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAI 240 Query: 557 HGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSK 616 ++ + P +K + S+ T+ + I H+ + R+ ++ Sbjct: 241 ATKDVRIFTLKPVRKELTSSGGP------------TKFEIHIVAQFDNHNSQVWRVSWNI 288 Query: 617 DGKFLLSVCRDRKWALWERNMEDN 640 G L S D LW+ N DN Sbjct: 289 TGTVLASSGDDGCVRLWKANYMDN 312 >4A11-B nrPDB Length = 408 Score = 101 bits (251), Expect = 1e-21, Method: Composition-based stats. Identities = 57/391 (14%), Positives = 125/391 (31%), Gaps = 65/391 (16%) Query: 58 HEAEVTCVRFVP-DSDFMVSASEDHHVKIWKFTDYSH---LQCI------QTIQH-YSKT 106 H + + P + +M+S D + ++ + S C + + + Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 107 IVALSALPS---LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEE 163 + + P + + D T+ +W N E T+ +S V Sbjct: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHH-------MSPVST 154 Query: 164 KKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCS 223 K L+A+G V + ++ L+GH + ++++ + DY+L + Sbjct: 155 KHCLVAVGTRGPKVQL-------CDLKSGSCSHILQGHRQEILAVSWSPRY---DYILAT 204 Query: 224 GSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDW 283 S D ++LW +R L++ Q+ + E+ H+ Sbjct: 205 ASADSRVKLWDVRRASG-----------CLITLDQH------NGKKSQAVESANTAHNGK 247 Query: 284 ISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATG-SSGGFW 342 ++ L + L LL D + +W V ++ S KG + Sbjct: 248 VNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEF 307 Query: 343 SCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLA 402 + + + + +G+ + + G K V + + + L + Sbjct: 308 VFVPYGSTIAVYTVYSGEQITM----------------LKGHYKTVDCCVFQSNFQELYS 351 Query: 403 TSLDQTTRLFAPWIYDASGRKREIATWHEFS 433 S D + P +Y+ E T + + Sbjct: 352 GSRDCNILAWVPSLYEPVPDDDETTTKSQLN 382 Score = 85.0 bits (208), Expect = 1e-16, Method: Composition-based stats. Identities = 55/360 (15%), Positives = 113/360 (31%), Gaps = 56/360 (15%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKG-----------HEAEVTCVRFVP-DSD 72 + + +++ G+ I L+D + + Y T K H V V++ P D+ Sbjct: 55 EGRYMLSGGSDGVIVLYDLENSSRQSYY-TCKAVCSIGRDHPDVHRYSVETVQWYPHDTG 113 Query: 73 FMVSASEDHHVKIWKFTDYSHLQCIQTIQ-HYSKTIVALSALPSLISVGCADGTISIWRQ 131 S+S D +K+W + YS + +S L++VG + + Sbjct: 114 MFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDL 173 Query: 132 NIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSD----- 186 + +H + L++S Y+LA + V + + Sbjct: 174 KSGS----CSHILQGHR----QEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLIT 225 Query: 187 ----SGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLID 242 +G + V + H V L F T L + D +RLW + Sbjct: 226 LDQHNGKKSQAVESANTAHNGKVNGLCF----TSDGLHLLTVGTDNRMRLWNSSNGENTL 281 Query: 243 DS-----EEDSKKLTLLSNKQYKFQI-----DDELRVGINFEA----LIMGHDDWISSLQ 288 + K L + + + V + ++ GH + Sbjct: 282 VNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCV 341 Query: 289 WHESRLQLLAATADTSLMVW-------EPDETSGIWVCSLRLGEMSSKGASTATGSSGGF 341 + + +L + + D +++ W PD+ L + +S G + + Sbjct: 342 FQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAWSSSDEEGGTSAW 401 Score = 76.5 bits (186), Expect = 4e-14, Method: Composition-based stats. Identities = 47/300 (15%), Positives = 91/300 (30%), Gaps = 72/300 (24%) Query: 24 HKVKKIVAFGAGKTIALWDPIEPNN----------------------------------- 48 H + KT+ +WD Sbjct: 110 HDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQ 169 Query: 49 ------KGVYATLKGHEAEVTCVRFVPDSDF-MVSASEDHHVKIWKF------------T 89 L+GH E+ V + P D+ + +AS D VK+W Sbjct: 170 LCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQH 229 Query: 90 DYSHLQCIQTI-QHYSKTIV--ALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTI 146 + Q +++ ++ + ++ + D + +W N N E L + + Sbjct: 230 NGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLW--NSSNGENTLVNYGKV 287 Query: 147 KKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVK 206 L ++S +++ G+ + V+ + + L+GH V Sbjct: 288 CNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYT---------VYSGEQITMLKGHYKTVD 338 Query: 207 SLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDE 266 F+ L SGS+D I W + + + D +E + K L + + DE Sbjct: 339 CCVFQ----SNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAWSSSDE 394 Score = 43.0 bits (99), Expect = 6e-04, Method: Composition-based stats. Identities = 54/282 (19%), Positives = 91/282 (32%), Gaps = 67/282 (23%) Query: 384 ATKDVTDIAWSP-SGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFS----RPQIH 438 + + P G Y+L+ D L+ + S R+ S P +H Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDL---ENSSRQSYYTCKAVCSIGRDHPDVH 98 Query: 439 GYDMICVETV--TDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVP 496 Y + V+ F S +K L+ +D LQ FEE TV Sbjct: 99 RYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNT-----LQTADVFNFEE--------TVY 145 Query: 497 VLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVE---- 552 +S P+S C + +++ Sbjct: 146 SHHMS---------------------------PVSTKHCLVAVGTRGPKVQLCDLKSGSC 178 Query: 553 --KLYGHGFEITCLDISPD-QKLIASACRSNNVQNAVIR----------IFSTENWLEIK 599 L GH EI + SP ++A+A + V+ +R + + ++ Sbjct: 179 SHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVE 238 Query: 600 PALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNT 641 A H+ + L F+ DG LL+V D + LW + +NT Sbjct: 239 SANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENT 280 Score = 41.4 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 34/209 (16%), Positives = 61/209 (29%), Gaps = 50/209 (23%) Query: 526 ITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISP-DQKLIASACRSNNVQN 584 + DPL L L L + + HG I LDI P + + + S + Sbjct: 12 LEDPLRLRRAESTRRVLGLELN-KDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVL 70 Query: 585 AVIRIFSTENWLEIKPAL-------PFHSLTITRLKFSK-DGKFLLSVCRDRKWALWERN 636 + S +++ K H ++ +++ D S D+ +W+ N Sbjct: 71 YDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTN 130 Query: 637 M---------------------------------------EDNTFELRFKNEKPHTRIIW 657 D + H + I Sbjct: 131 TLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEIL 190 Query: 658 DADWAPLEFGNVFVTASRDKTVKVWRHQK 686 W+P + + TAS D VK+W ++ Sbjct: 191 AVSWSP-RYDYILATASADSRVKLWDVRR 218 Score = 33.3 bits (74), Expect = 0.40, Method: Composition-based stats. Identities = 8/41 (19%), Positives = 17/41 (41%) Query: 550 EVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIF 590 ++ L GH + C + + + S R N+ V ++ Sbjct: 326 QITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLY 366 >6ELZ-p nrPDB Length = 460 Score = 98.4 bits (243), Expect = 1e-20, Method: Composition-based stats. Identities = 63/419 (15%), Positives = 129/419 (30%), Gaps = 83/419 (19%) Query: 59 EAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSA-LPSLI 117 E V+ + S ++S S D V+ W + + +S I A+ + + Sbjct: 103 EDWVSSLDVGDGSKHIISGSYDGIVRTWDLS----GNVQKQYSGHSGPIRAVKYISNTRL 158 Query: 118 SVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNV 177 D T+ +W+ +ND+ L + Sbjct: 159 VSAGNDRTLRLWK--TKNDDLKLTSQQQ-------------------------------- 184 Query: 178 FIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRI 237 + IE + +A LEGH+ V S+ + + S S D I W Sbjct: 185 -AQEDDDDEVNIEDGKTLAILEGHKAPVVSIDVS-----DNSRILSASYDNSIGFWSTIY 238 Query: 238 NDLI-----DDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQW-HE 291 ++ +D + K++ + K+ K + D +L+ H + + + Sbjct: 239 KEMTVVDPLEDINNPNNKISTAARKRRKLTMKDGTIRRRAPLSLLESHTAPVEQVIFDST 298 Query: 292 SRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHER 351 + + D ++ W+ I + S S A S+ +C Sbjct: 299 DNTVGYSVSQDHTIKTWDLVTARCIDTRT-----TSYSLLSIAQLSTLNLLACGSSARHI 353 Query: 352 MDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYL-LATSLDQTTR 410 G + + Q+ + G V+ + P EY+ + S D T + Sbjct: 354 TLHDPRVGASS----------KVTQQQ--LIGHKNFVSSLDTCPENEYILCSGSHDGTVK 401 Query: 411 LFAPWIYDASGRKREIATWHEFSRPQIH-----GYDMICVETVTDTRFVSGGDEKILRS 464 ++D R + + +R + V+ +S G +K ++ Sbjct: 402 -----VWDV----RSTSPMYTITREDKSVQKGVNDKVFAVKWAEKVGIISAGQDKKIQI 451 Score = 84.6 bits (207), Expect = 2e-16, Method: Composition-based stats. Identities = 47/289 (16%), Positives = 93/289 (32%), Gaps = 75/289 (25%) Query: 8 EAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDP--------------------IEPN 47 + + G + + ++V+ G +T+ LW + Sbjct: 137 QKQYSGHSGPIRAVKYISNTRLVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIE 196 Query: 48 NKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFT------------------ 89 + A L+GH+A V + D+ ++SAS D+ + W Sbjct: 197 DGKTLAILEGHKAPVVSIDVS-DNSRILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNN 255 Query: 90 -----------------DYSHLQCIQTIQHYSKTIVALSALPSLISVG---CADGTISIW 129 + ++ ++ + + + +VG D TI W Sbjct: 256 KISTAARKRRKLTMKDGTIRRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTW 315 Query: 130 RQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGI 189 T + LS + LLA G + ++ + + S Sbjct: 316 DLVTARC------IDTRTTSYSLLSIAQLSTLN----LLACGSSARHITLHDPRVGASSK 365 Query: 190 EKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRIN 238 + L GH+++V SL + +Y+LCSGS D +++W +R Sbjct: 366 VTQQQ---LIGHKNFVSSLDTCPE---NEYILCSGSHDGTVKVWDVRST 408 Score = 53.0 bits (125), Expect = 4e-07, Method: Composition-based stats. Identities = 51/402 (12%), Positives = 108/402 (26%), Gaps = 69/402 (17%) Query: 337 SSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPS 396 S+ + S L ++ G R W N+ G + + + + S Sbjct: 101 SNEDWVSSLDVGD-GSKHIISGSYDGIVRTWDLSGNVQKQYS----GHSGPIRAVKY-IS 154 Query: 397 GEYLLATSLDQTTRLFAPWIYDAS-----------GRKREIATWHEFSRPQIHGYDMICV 445 L++ D+T RL+ D + I + + H ++ + Sbjct: 155 NTRLVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSI 214 Query: 446 ETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATV--PVLGLSNK 503 + ++R +S + + + S + TV P+ Sbjct: 215 DVSDNSRILSASYDNSIGFW---------------------STIYKEMTVVDPL------ 247 Query: 504 AGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITC 563 ED N +++ K ++ P + L H + Sbjct: 248 --EDINNPNNKISTAARKRRKLTMKDGTIRRRAP-------------LSLLESHTAPVEQ 292 Query: 564 LDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLS 623 + + S + + + S ++ + L Sbjct: 293 VIFDSTDNTV---GYSVSQDHTIKTWDLVTARCIDTRTT---SYSLLSIAQLSTLNLLAC 346 Query: 624 VCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWR 683 R L + + + ++ + H + D P E + + S D TVKVW Sbjct: 347 GSSARHITLHDPRVG-ASSKVTQQQLIGHKNFVSSLDTCP-ENEYILCSGSHDGTVKVWD 404 Query: 684 HQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLE 725 + + K V + +IS G + Sbjct: 405 VRSTSPMYTITREDKSVQKGVNDKVFAVKWAEKVGIISAGQD 446 Score = 51.4 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 34/252 (13%), Positives = 63/252 (25%), Gaps = 83/252 (32%) Query: 9 AIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPN--------------------- 47 AI G D+ +I++ +I W I Sbjct: 202 AILEGHKAPVVSIDVSDNSRILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAA 261 Query: 48 --------------NKGVYATLKGHEAEVTCVRF-VPDSDFMVSASEDHHVKIWKFTDYS 92 + + L+ H A V V F D+ S S+DH +K W Sbjct: 262 RKRRKLTMKDGTIRRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTAR 321 Query: 93 HLQC------------------------------------------IQTIQHYSKTIVAL 110 + Q + + + +L Sbjct: 322 CIDTRTTSYSLLSIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSL 381 Query: 111 SALPS---LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYL 167 P ++ G DGT+ +W + + + E + ++ E K Sbjct: 382 DTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITREDKSVQKGVNDKVFAVKWAE--KVG 439 Query: 168 LAIGGTNVNVFI 179 + G + + I Sbjct: 440 IISAGQDKKIQI 451 Score = 46.0 bits (107), Expect = 6e-05, Method: Composition-based stats. Identities = 36/242 (14%), Positives = 75/242 (30%), Gaps = 70/242 (28%) Query: 278 MGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGS 337 ++DW+SSL + +++ + D + W+ G Sbjct: 100 FSNEDWVSSLDVGDGSKHIISGSYDGIVRTWDLSGNVQKQYS----------------GH 143 Query: 338 SGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLG----------------- 380 SG + + ++ R ++ G + R+W TK++ + Sbjct: 144 SGPIRAVKYISNTR---LVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKT 200 Query: 381 ---ISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIY-------------------D 418 + G V I S +L+ S D + ++ IY Sbjct: 201 LAILEGHKAPVVSIDVS-DNSRILSASYDNSIGFWST-IYKEMTVVDPLEDINNPNNKIS 258 Query: 419 ASGRKREIATWHE--------FSRPQIHGYDMICV--ETVTDTRFVSGGDEKILRSFDLP 468 + RKR T + S + H + V ++ +T S + ++++DL Sbjct: 259 TAARKRRKLTMKDGTIRRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLV 318 Query: 469 KG 470 Sbjct: 319 TA 320 Score = 43.3 bits (100), Expect = 4e-04, Method: Composition-based stats. Identities = 30/156 (19%), Positives = 57/156 (36%), Gaps = 23/156 (14%) Query: 544 RHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALP 603 R +L P + + ++ LD+ K I S ++R + ++ + + Sbjct: 89 RAILPPSYLNSFSNEDWVSSLDVGDGSKHIISGSYDG-----IVRTWDLSGNVQKQYS-- 141 Query: 604 FHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFEL----------RFKNEKPHT 653 HS I +K+ + + L+S DR LW+ +D E T Sbjct: 142 GHSGPIRAVKYISNTR-LVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKT 200 Query: 654 RIIWDADWAPLEFGNV-----FVTASRDKTVKVWRH 684 I + AP+ +V ++AS D ++ W Sbjct: 201 LAILEGHKAPVVSIDVSDNSRILSASYDNSIGFWST 236 Score = 33.3 bits (74), Expect = 0.41, Method: Composition-based stats. Identities = 28/186 (15%), Positives = 63/186 (33%), Gaps = 37/186 (19%) Query: 609 ITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGN 668 ++ L K ++S D W+ + + ++ R + Sbjct: 106 VSSLDVGDGSKHIISGSYDGIVRTWDLS---GNVQKQYSGHSGPIRAVKYI------SNT 156 Query: 669 VFVTASRDKTVKVWRHQKE-------------------PADDYVLEASIKHTKAVTAISI 709 V+A D+T+++W+ + + D L H V +I + Sbjct: 157 RLVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDV 216 Query: 710 HDSMIREKILISVGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKL 769 D+ ++S +N I +S + ++ L + P +KI+ ++ KL Sbjct: 217 SDN----SRILSASYDNS-IGFWSTIYKEMTVVDPLEDINNPNNKISTA----ARKRRKL 267 Query: 770 FLGVGS 775 + G+ Sbjct: 268 TMKDGT 273 >6BX3-A nrPDB Length = 314 Score = 97.7 bits (241), Expect = 2e-20, Method: Composition-based stats. Identities = 41/245 (16%), Positives = 81/245 (33%), Gaps = 13/245 (5%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 I ++ + + G+ T GH A V + F + + ++S D +KIW Sbjct: 69 IATASDDFSVEIIHL----SYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDT 124 Query: 89 TDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKK 148 + S ++ I ++ S++S G DG I I+ + L ++ K+ Sbjct: 125 LNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKR 184 Query: 149 GFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSL 208 + E +YLL + V I + + +V +G + Sbjct: 185 ENGVVPISQVKFSENARYLLVK-SLDGVVKIWD-CIGGCVVRTFQVQPLEKGVLHHSCGM 242 Query: 209 AFRHQETPGDYLLCSGSQDRYIRLWRIRINDLID-------DSEEDSKKLTLLSNKQYKF 261 F + E L+ SG ++ I W L+ + N Sbjct: 243 DFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSL 302 Query: 262 QIDDE 266 ++ + Sbjct: 303 ALNGD 307 Score = 79.6 bits (194), Expect = 6e-15, Method: Composition-based stats. Identities = 36/219 (16%), Positives = 73/219 (33%), Gaps = 29/219 (13%) Query: 23 IHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHH 82 I + +A G I ++D T H + + + PD + +AS+D Sbjct: 20 ISPDGQFLAITQGLNILIYDINRRTVSQTLVT--SHARPFSELCWSPDGQCIATASDDFS 77 Query: 83 VKIWKFTDYSHLQCIQTIQHYSKTIVALSAL--PSLISVGCADGTISIWRQ-NIQNDEFG 139 V+I + + T ++ +++L+ +L+ D +I IW N + Sbjct: 78 VEI----IHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTI 133 Query: 140 LAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELE 199 AH + +S+ +L+ G + + I E + L Sbjct: 134 SAHSEAV---------VSVDVPMNDSSILSSGSYDGLIRI-------FDAETGHCLKTLT 177 Query: 200 GHEDWVKSLAFRHQE----TPGDYLLCSGSQDRYIRLWR 234 +DW + + L S D +++W Sbjct: 178 YDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWD 216 Score = 75.3 bits (183), Expect = 1e-13, Method: Composition-based stats. Identities = 43/240 (17%), Positives = 83/240 (34%), Gaps = 32/240 (13%) Query: 10 IFIGAN-KQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRF- 67 FIG ++ K + ++I +WD + N + T+ H V V Sbjct: 90 TFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTL---NGSLMKTISAHSEAVVSVDVP 146 Query: 68 VPDSDFMVSASEDHHVKIWKFTDYSHLQCIQ-----TIQHYSKTIVALSALPS--LISVG 120 + DS + S S D ++I+ L+ + ++ I + + + V Sbjct: 147 MNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVK 206 Query: 121 CADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLS--LSKVEEKKYLLAIGGTNVNVF 178 DG + IW I ++KG + C L+ + L+ G N +++ Sbjct: 207 SLDGVVKIWDC-IGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIY 265 Query: 179 IASFILSDSGIEKCRVVAELEG----HEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWR 234 + ++ L+G H V S+ ++CS + + LWR Sbjct: 266 CW-------NSDTKSLLQLLDGSLYHHSSPVMSIHCF------GNIMCSLALNGDCCLWR 312 Score = 71.1 bits (172), Expect = 2e-12, Method: Composition-based stats. Identities = 48/314 (15%), Positives = 95/314 (30%), Gaps = 53/314 (16%) Query: 63 TCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCA 122 TC + PD F+ ++ ++ I+ + Q + T + + S I+ Sbjct: 16 TCAKISPDGQFLA-ITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASD 74 Query: 123 DGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASF 182 D ++ I + +GL H F L K LL + ++ I Sbjct: 75 DFSVEIIHLS-----YGLLHTFIGHTAPVISLTF-----NRKGNLLFTSSMDESIKIWDT 124 Query: 183 ILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLID 242 + ++ + H + V S+ +L SGS D IR++ Sbjct: 125 L-------NGSLMKTISAHSEAVVSVDV---PMNDSSILSSGSYDGLIRIFDAET----- 169 Query: 243 DSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATAD 302 TL +K +K G+ IS +++ E+ LL + D Sbjct: 170 ----GHCLKTLTYDKDWKR------ENGVVP----------ISQVKFSENARYLLVKSLD 209 Query: 303 TSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTG 362 + +W+ + ++ E S L ++ + G Sbjct: 210 GVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMD-------FLNPEDGSTPLVISGYENG 262 Query: 363 SWRMWATKDNIICD 376 W + + Sbjct: 263 DIYCWNSDTKSLLQ 276 Score = 59.1 bits (141), Expect = 6e-09, Method: Composition-based stats. Identities = 37/192 (19%), Positives = 73/192 (38%), Gaps = 21/192 (10%) Query: 557 HGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSK 616 +G + TC ISPD + +A Q I I+ + + H+ + L +S Sbjct: 11 NGLKATCAKISPDGQFLA------ITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSP 64 Query: 617 DGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRD 676 DG+ + + D + + HT + GN+ T+S D Sbjct: 65 DGQCIATASDDFSVEI------IHLSYGLLHTFIGHTAPVIS--LTFNRKGNLLFTSSMD 116 Query: 677 KTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTL 736 +++K+W + +++ H++AV ++ + M IL S + G I ++ Sbjct: 117 ESIKIWDTL----NGSLMKTISAHSEAVVSVDV--PMNDSSILSSGSYD-GLIRIFDAET 169 Query: 737 GKFELITQLNED 748 G ++D Sbjct: 170 GHCLKTLTYDKD 181 Score = 46.8 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 29/178 (16%), Positives = 60/178 (33%), Gaps = 16/178 (8%) Query: 240 LIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEAL-----IMGHDDWISSLQWHESRL 294 L+ +L + Q D+ V I + +GH + SL ++ Sbjct: 49 LVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGN 108 Query: 295 QLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDF 354 L ++ D S+ +W+ S + S + + + S + F Sbjct: 109 LLFTSSMDESIKIWDTLNGSLMKTIS---AHSEAVVSVDVPMNDSSILSSGSYDGLIRIF 165 Query: 355 FLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLF 412 + +TG T D + + ++ + +S + YLL SLD +++ Sbjct: 166 ---DAETGHCLKTLTYDKDWKRENGVVP-----ISQVKFSENARYLLVKSLDGVVKIW 215 Score = 46.4 bits (108), Expect = 5e-05, Method: Composition-based stats. Identities = 54/326 (16%), Positives = 105/326 (32%), Gaps = 64/326 (19%) Query: 393 WSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTR 452 SP G++L T+ IYD + R +RP + Sbjct: 20 ISPDGQFLA------ITQGLNILIYDINRRTVSQTLVTSHARPFSELCW-----SPDGQC 68 Query: 453 FVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLS-NKAGEDDANE 511 + D+ + L G +L F+G T PV+ L+ N+ G Sbjct: 69 IATASDDFSVEIIHLSYG---LLHTFIG------------HTAPVISLTFNRKG------ 107 Query: 512 DDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQK 571 ++ S+ E + D L L+ + + H + +D+ + Sbjct: 108 -------------NLLFTSSMDESIKIWDTLNGSLM----KTISAHSEAVVSVDVPMNDS 150 Query: 572 LIASACRSNNVQNAVIRIFSTENWLEIKPAL-------PFHSLTITRLKFSKDGKFLLSV 624 I S+ + +IRIF E +K + I+++KFS++ ++LL Sbjct: 151 SILSSGSY----DGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVK 206 Query: 625 CRDRKWALWERNMEDNTFELRFK-NEKP--HTRIIWDADWAPLEFGNVFVTASRDKTVKV 681 D +W+ + + EK H D + ++ + + Sbjct: 207 SLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYC 266 Query: 682 WRHQKEPADDYVLEASIKHTKAVTAI 707 W + + + H+ V +I Sbjct: 267 WNSDTKSLLQLLDGSLYHHSSPVMSI 292 >3F3P-A nrPDB Length = 351 Score = 96.5 bits (238), Expect = 4e-20, Method: Composition-based stats. Identities = 44/318 (13%), Positives = 112/318 (35%), Gaps = 38/318 (11%) Query: 26 VKKIVAFGAGKTIALWDPIEPNNK-GVYATLKGHEAEVTCVRFVPD--SDFMVSASEDHH 82 + + + + I ++ + + + + + H++ + + + + SAS D Sbjct: 23 GRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKT 82 Query: 83 VKIWKFT------DYSHLQCIQTIQHYSKTIVALSALPS----LISVGCADGTISIWRQN 132 VK+W+ + T+ ++ ++ P+ ++ DG + ++ Sbjct: 83 VKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDAL 142 Query: 133 IQNDEFGLAHEFTIKKGFFYPL-------CLSLSKVEEKKYLLAIGGTNVNVFIASFILS 185 +D +K P CLS LA+ + I Sbjct: 143 EPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAI-----IYQ 197 Query: 186 DSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWR-------IRIN 238 K V A+L GH+ ++S+++ L+ +G +D IR+++ + Sbjct: 198 RGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASE 257 Query: 239 DLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIM------GHDDWISSLQWHES 292 + + +S + + Q + + E + + + H+ + S+ W+ + Sbjct: 258 ESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLT 317 Query: 293 RLQLLAATADTSLMVWEP 310 L +A D + +W+ Sbjct: 318 GTILSSAGDDGKVRLWKA 335 Score = 66.5 bits (160), Expect = 5e-11, Method: Composition-based stats. Identities = 58/372 (15%), Positives = 120/372 (32%), Gaps = 63/372 (16%) Query: 57 GHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF-TDYSHLQCIQTIQHYSKTIVALSALPS 115 GH+ V V + + + S D H+K++K D S+ + + + + +IVA+ Sbjct: 9 GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASP 68 Query: 116 ----LISVGCADGTISIWRQNIQNDEFGLAHEF---TIKKGFFYPLCLSLSKVEEKKYLL 168 +I+ D T+ +W ++ +E T+ + + L Sbjct: 69 EYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLG-LKL 127 Query: 169 AIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDR 228 A G + + + L S + + +E++ L+ S Sbjct: 128 ACLGNDGILRLYD-ALEPSDLRSWTLTSEMK-------VLSIPPANHLQSDFCLS----- 174 Query: 229 YIRLWRIRINDLIDDSEEDSKKLTLLSNKQ---YKFQIDDELRVGINFEALIMGHDDWIS 285 W S +KL + + +Q Y+ D +L V A + GH I Sbjct: 175 ----W--------CPSRFSPEKLAVSALEQAIIYQRGKDGKLHVA----AKLPGHKSLIR 218 Query: 286 SLQWHES----RLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGF 341 S+ W S + D + + ++ E S AS + ++ Sbjct: 219 SISWAPSIGRWYQLIATGCKDGRIRI-------------FKITEKLSPLASEESLTNSNM 265 Query: 342 WSCLWFTHERMDFFLTNGKT-GSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYL 400 + +D + + N+ + +V ++W+ +G L Sbjct: 266 FD----NSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTIL 321 Query: 401 LATSLDQTTRLF 412 + D RL+ Sbjct: 322 SSAGDDGKVRLW 333 Score = 51.4 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 27/156 (17%), Positives = 61/156 (39%), Gaps = 8/156 (5%) Query: 599 KPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWD 658 +P H + + + G+ + + D+ +++ + + + +EL + + H I Sbjct: 4 QPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELS-DSWRAHDSSIVA 62 Query: 659 ADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDY-----VLEASIKHTKAVTAISIHDSM 713 DWA E+G + +AS DKTVK+W + + L ++ ++ + Sbjct: 63 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 122 Query: 714 IREKILISVGLENGEIYLYSYTLGKFELITQLNEDI 749 + K+ +G + LY L ++ Sbjct: 123 LGLKLACLG--NDGILRLYDALEPSDLRSWTLTSEM 156 Score = 46.8 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 13/45 (28%), Positives = 21/45 (46%) Query: 58 HEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQH 102 H EV V + + SA +D V++WK T + +C+ I Sbjct: 305 HNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITA 349 >3C9C-A nrPDB Length = 432 Score = 95.7 bits (236), Expect = 6e-20, Method: Composition-based stats. Identities = 47/281 (16%), Positives = 102/281 (36%), Gaps = 52/281 (18%) Query: 42 DPIEPNNKGVYATLKGHEAEVTCVRFVPD-SDFMVSASEDHHVKIWKFT-DYSHLQCIQT 99 +P + L+GH+ E + + P+ + +++SAS+DH + +W + I Sbjct: 168 EPSGECQPDL--RLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDA 225 Query: 100 ---IQHYSKTIVALSA---LPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYP 153 ++ + ++ SL D + IW + +N+ T+ Sbjct: 226 KNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIW--DTRNNNTSKPSH-TVDAHTAEV 282 Query: 154 LCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRV-VAELEGHEDWVKSLAFRH 212 CLS + E ++LA G + V + + ++ + E H+D + + + Sbjct: 283 NCLSFNPYSE--FILATGSADKTVALW-------DLRNLKLKLHSFESHKDEIFQVQWSP 333 Query: 213 QETPGDYLLCSGSQDRYIRLWRIR---INDLIDDSEEDSKKLTLLSNKQYKFQIDDELRV 269 +L S DR + +W + +D+E+ +L + Sbjct: 334 HNET---ILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHG------------- 377 Query: 270 GINFEALIMGHDDWISSLQWHESRLQLL-AATADTSLMVWE 309 GH IS W+ + ++ + + D + VW+ Sbjct: 378 ---------GHTAKISDFSWNPNEPWIICSVSEDNIMQVWQ 409 Score = 86.1 bits (211), Expect = 6e-17, Method: Composition-based stats. Identities = 59/356 (16%), Positives = 114/356 (32%), Gaps = 76/356 (21%) Query: 58 HEAEVTCVRFVPDSDFMVSA---SEDHHVKIWKFTDYSHL-------QCIQTIQHYSKTI 107 HE EV R++P + +++ S D V ++ +T + Q ++ + K Sbjct: 129 HEGEVNRARYMPQNACVIATKTPSSD--VLVFDYTKHPSKPEPSGECQPDLRLRGHQKEG 186 Query: 108 VALSALPSL---ISVGCADGTISIWRQN--------IQNDEFGLAHEFTIKKGFFYPLCL 156 LS P+L + D TI +W N I H ++ ++ L Sbjct: 187 YGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHE 246 Query: 157 SLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETP 216 S L + + I ++ + ++ H V L+F Sbjct: 247 S---------LFGSVADDQKLMIWDTRNNN----TSKPSHTVDAHTAEVNCLSFNPYSE- 292 Query: 217 GDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEAL 276 ++L +GS D+ + LW +R L S E Sbjct: 293 --FILATGSADKTVALWDLRNLKLKLHSFE------------------------------ 320 Query: 277 IMGHDDWISSLQWHESRLQLLAAT-ADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTAT 335 H D I +QW +LA++ D L VW+ G + + + Sbjct: 321 --SHKDEIFQVQWSPHNETILASSGTDRRLHVWDL-SKIGEEQSTEDAEDGPPELLFIHG 377 Query: 336 GSSGGFWSCLWFTHERMDFFL-TNGKTGSWRMWATKDNIICDQRLGISGATKDVTD 390 G + W + + + + + ++W +N+ D+ I + + Sbjct: 378 GHTAKISDFSW--NPNEPWIICSVSEDNIMQVWQMAENVYNDEEPEIPASELETNT 431 Score = 85.7 bits (210), Expect = 6e-17, Method: Composition-based stats. Identities = 31/199 (15%), Positives = 66/199 (33%), Gaps = 14/199 (7%) Query: 5 ITPEAIFIGANKQTQVSDIH--KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEV 62 I + IF G + H + + + +WD N T+ H AEV Sbjct: 223 IDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEV 282 Query: 63 TCVRFVPDSDF-MVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS---LIS 118 C+ F P S+F + + S D V +W + + + + + I + P +++ Sbjct: 283 NCLSFNPYSEFILATGSADKTVALWDLRNLKL--KLHSFESHKDEIFQVQWSPHNETILA 340 Query: 119 VGCADGTISIWRQN-IQNDEFGLAHEFTIK-----KGFFYPLCLSLSKVEEKKYLLAIGG 172 D + +W + I ++ E G S + +++ Sbjct: 341 SSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVS 400 Query: 173 TNVNVFIASFILSDSGIEK 191 + + + + E+ Sbjct: 401 EDNIMQVWQMAENVYNDEE 419 Score = 73.0 bits (177), Expect = 4e-13, Method: Composition-based stats. Identities = 41/202 (20%), Positives = 79/202 (39%), Gaps = 26/202 (12%) Query: 273 FEALIMGHDDWISSLQWHES-RLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGA 331 + + GH L W+ + LL+A+ D ++ +W+ + T Sbjct: 175 PDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKE--------HRVIDAK 226 Query: 332 STATGSSGGFWSCLWFT-HERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTD 390 + TG + W HE + F + +W T++N + T +V Sbjct: 227 NIFTGHTAVVEDVAWHLLHESL--FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNC 284 Query: 391 IAWSPSGEYLL-ATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVE--T 447 ++++P E++L S D+T L +D K ++ H F + H ++ V+ Sbjct: 285 LSFNPYSEFILATGSADKTVAL-----WDLRNLKLKL---HSF---ESHKDEIFQVQWSP 333 Query: 448 VTDTRFVSGGDEKILRSFDLPK 469 +T S G ++ L +DL K Sbjct: 334 HNETILASSGTDRRLHVWDLSK 355 Score = 72.2 bits (175), Expect = 7e-13, Method: Composition-based stats. Identities = 49/320 (15%), Positives = 97/320 (30%), Gaps = 65/320 (20%) Query: 137 EFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIE---KCR 193 E + HE + + + P ++A + +V + + S E +C+ Sbjct: 124 EIKINHEGEVNRARYMPQNAC---------VIATKTPSSDVLVFDYTKHPSKPEPSGECQ 174 Query: 194 VVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI----RINDLIDDSEE--- 246 L GH+ L++ L S S D I LW I + + +ID Sbjct: 175 PDLRLRGHQKEGYGLSWNPNLNG---YLLSASDDHTICLWDINATPKEHRVIDAKNIFTG 231 Query: 247 ------------DSKKLTLLSNKQYKFQIDDELRVGI-NFEALIMGHDDWISSLQWHESR 293 + L K I D + H ++ L ++ Sbjct: 232 HTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYS 291 Query: 294 LQLL-AATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERM 352 +L +AD ++ +W+ L + K S + W H Sbjct: 292 EFILATGSADKTVALWD-------------LRNLKLKLHSFE-SHKDEIFQVQWSPHN-E 336 Query: 353 DFFLTNGKTGSWRMWATKDNIICDQR-----------LGISGATKDVTDIAWSPSGEY-L 400 ++G +W G T ++D +W+P+ + + Sbjct: 337 TILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWII 396 Query: 401 LATSLDQTTRLF--APWIYD 418 + S D +++ A +Y+ Sbjct: 397 CSVSEDNIMQVWQMAENVYN 416 Score = 55.3 bits (131), Expect = 9e-08, Method: Composition-based stats. Identities = 42/237 (17%), Positives = 79/237 (33%), Gaps = 25/237 (10%) Query: 550 EVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRI------FSTENWLEIKPALP 603 E+E H E+ P Q A ++ + V + L Sbjct: 122 EIEIKINHEGEVNRARYMP-QNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLR 180 Query: 604 FHSLTITRLKFSKDGK-FLLSVCRDRKWALWERNM--EDNTFELRFKNEKPHTRIIWDAD 660 H L ++ + +LLS D LW+ N +++ HT ++ D Sbjct: 181 GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 240 Query: 661 WAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHD-------SM 713 W L ++F + + D+ + +W + HT V +S + + Sbjct: 241 WHLLH-ESLFGSVADDQKLMIWDTRNNNTSKPS-HTVDAHTAEVNCLSFNPYSEFILATG 298 Query: 714 IREKILISVGLENGEIYLYSYTLGK---FELITQLNEDITPADKITRLR---WSHLK 764 +K + L N ++ L+S+ K F++ + + A T R W K Sbjct: 299 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSK 355 Score = 54.1 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 33/153 (21%), Positives = 60/153 (39%), Gaps = 17/153 (11%) Query: 554 LYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLK 613 + H E+ CL +P + I + + + + ++ N + H I +++ Sbjct: 275 VDAHTAEVNCLSFNPYSEFILATGSA----DKTVALWDLRNLKLKLHSFESHKDEIFQVQ 330 Query: 614 FSK-DGKFLLSVCRDRKWALWE----------RNMEDNTFELRFKNEKPHTRIIWDADWA 662 +S + L S DR+ +W+ + ED EL F HT I D W Sbjct: 331 WSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFI-HGGHTAKISDFSWN 389 Query: 663 PLEFGNVFVTASRDKTVKVWRHQKEPADDYVLE 695 P E + + S D ++VW+ + +D E Sbjct: 390 PNE-PWIICSVSEDNIMQVWQMAENVYNDEEPE 421 Score = 35.6 bits (80), Expect = 0.093, Method: Composition-based stats. Identities = 52/279 (18%), Positives = 95/279 (34%), Gaps = 47/279 (16%) Query: 375 CDQRLGISGATKDVTDIAWSPS-GEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFS 433 C L + G K+ ++W+P+ YLL+ S D T L+ I R I + F+ Sbjct: 173 CQPDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWD--INATPKEHRVIDAKNIFT 230 Query: 434 RPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSA 493 D+ + ++ F S D++ L +D + S D+ Sbjct: 231 GHTAVVEDVAW-HLLHESLFGSVADDQKLMIWDTRNN-----------NTSKPSHTVDAH 278 Query: 494 TVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEK 553 T V LS N + I S + + D L ++ Sbjct: 279 TAEVNCLSF-----------------NPYSEFILATGSADKTVALWDLRNLKL---KLHS 318 Query: 554 LYGHGFEITCLDISP-DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALP--------F 604 H EI + SP ++ ++AS+ + + E E P Sbjct: 319 FESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGG 378 Query: 605 HSLTITRLKFSKDGKFLL-SVCRDRKWALWERNMEDNTF 642 H+ I+ ++ + +++ SV D +W M +N + Sbjct: 379 HTAKISDFSWNPNEPWIICSVSEDNIMQVW--QMAENVY 415 >5WLC-LU nrPDB Length = 489 Score = 95.4 bits (235), Expect = 8e-20, Method: Composition-based stats. Identities = 43/342 (12%), Positives = 106/342 (30%), Gaps = 56/342 (16%) Query: 57 GHEAEVTCVRFVPDS-DFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSK--TIVALSAL 113 GH V + S + + + S D +K W + + + Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPRFH 124 Query: 114 P--------SLISVGCADGTISIWRQNI-------QNDEFGLAHEFTIKKGFFYPLCLSL 158 + + D T+ +W N+ +D + +E + + F Sbjct: 125 DKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAFQG 184 Query: 159 SKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGD 218 + A GG ++++ + + + V++L D + SL F ET Sbjct: 185 IDSHRENSTFATGGAKIHLW---------DVNRLKPVSDLSWGADNITSLKFNQNETD-- 233 Query: 219 YLLCSGSQDRYIRLWRIRINDLIDD--SEEDSKKLTLLSNKQYKFQIDDELRVGINFEAL 276 +L S D I L+ +R N + + + + F +E ++ Sbjct: 234 -ILASTGSDNSIVLYDLRTNSPTQKIVQTMRTNAICWNPMEAFNFVTANEDHNAYYYDMR 292 Query: 277 IMG--------HDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSS 328 + H + + + + +++ + D S+ +++ + G Sbjct: 293 NLSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNH-----------GHSRE 341 Query: 329 KGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATK 370 + + + + + ++ G+ R+W +K Sbjct: 342 IYHTKRMQH---VFQVKYSMDSK--YIISGSDDGNVRLWRSK 378 Score = 71.5 bits (173), Expect = 1e-12, Method: Composition-based stats. Identities = 29/256 (11%), Positives = 77/256 (30%), Gaps = 41/256 (16%) Query: 22 DIHKVKKIVAFGAGKTIALWDPIE--------------PNNKGVYATLKGHEAEVTCVRF 67 D+ +++ KT+ LW N +G+ T G E+ + Sbjct: 129 DLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDG-ESAFQGIDS 187 Query: 68 VPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTIS 127 ++ + + +W + + ++ +++ +D +I Sbjct: 188 HRENSTFATGG--AKIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSDNSIV 245 Query: 128 IWRQNIQNDEFGLAHEFTIKKGFFYPL---CLSLSKVEEKKYLLAIGGTNVNVFI----- 179 ++ + + + P+ + + Y + + ++ + Sbjct: 246 LYDLRTNSPTQKIVQTMRTNAICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLNVFKDHV 305 Query: 180 -----------ASFILSDSGIEKCRVVAELEGHEDWVKSLA-----FRHQETPGDYLLCS 223 I++ S + R+ GH + F+ + + + S Sbjct: 306 SAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIYHTKRMQHVFQVKYSMDSKYIIS 365 Query: 224 GSQDRYIRLWRIRIND 239 GS D +RLWR + + Sbjct: 366 GSDDGNVRLWRSKAWE 381 Score = 69.2 bits (167), Expect = 7e-12, Method: Composition-based stats. Identities = 24/109 (22%), Positives = 35/109 (32%), Gaps = 2/109 (1%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 V +D N K H + V V F P D +V+ S D ++I+K Sbjct: 277 FVTANEDHNAYYYDM--RNLSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKT 334 Query: 89 TDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDE 137 + T + V S I G DG + +WR Sbjct: 335 NHGHSREIYHTKRMQHVFQVKYSMDSKYIISGSDDGNVRLWRSKAWERS 383 Score = 66.1 bits (159), Expect = 5e-11, Method: Composition-based stats. Identities = 51/335 (15%), Positives = 113/335 (33%), Gaps = 79/335 (23%) Query: 168 LAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDY-------L 220 LA G + + + + + + H V L Sbjct: 83 LATGSADGVIKYWNMSTREEFV-------SFKAHYGLVTGLCVTQPRFHDKKPDLKSQNF 135 Query: 221 LCSGSQDRYIRLWRIRINDLIDDSEEDSKKLT-------------------------LLS 255 + S S D+ ++LW I ++D + + D+ +T + Sbjct: 136 MLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAFQGIDSHRENSTFA 195 Query: 256 NKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLL-AATADTSLMVWEPDETS 314 K + D R+ + + D I+SL+++++ +L + +D S+++++ Sbjct: 196 TGGAKIHLWDVNRL--KPVSDLSWGADNITSLKFNQNETDILASTGSDNSIVLYD----- 248 Query: 315 GIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNII 374 LR + K T ++ + F F+T + + + ++ + Sbjct: 249 ------LRTNSPTQKIVQTMRTNAICWNPMEAFN------FVTANEDHNAYYYDMRN--L 294 Query: 375 CDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSR 434 V D+ +SP+G+ ++ S D++ R++ T H SR Sbjct: 295 SRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIY--------------KTNHGHSR 340 Query: 435 PQIHGYDMICV----ETVTDTRFVSGGDEKILRSF 465 H M V ++ +SG D+ +R + Sbjct: 341 EIYHTKRMQHVFQVKYSMDSKYIISGSDDGNVRLW 375 Score = 56.8 bits (135), Expect = 3e-08, Method: Composition-based stats. Identities = 17/82 (20%), Positives = 40/82 (48%), Gaps = 5/82 (6%) Query: 15 NKQTQVSDIH---KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDS 71 + + V D+ +IV K+I ++ +++ +Y T + V V++ DS Sbjct: 303 DHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIYHTKR--MQHVFQVKYSMDS 360 Query: 72 DFMVSASEDHHVKIWKFTDYSH 93 +++S S+D +V++W+ + Sbjct: 361 KYIISGSDDGNVRLWRSKAWER 382 Score = 44.1 bits (102), Expect = 3e-04, Method: Composition-based stats. Identities = 19/121 (15%), Positives = 43/121 (35%), Gaps = 23/121 (19%) Query: 605 HSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKN--EKPHTRIIWDADWA 662 H + + FS G +++ D+ +++ N + K + D+ + Sbjct: 304 HVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIYHTKRMQHVFQVKYSMDSKY- 362 Query: 663 PLEFGNVFVTASRDKTVKVWR-----------HQKEPADDY--VLEASIKHTKAVTAISI 709 ++ S D V++WR +++ +Y L+ +H + IS Sbjct: 363 -------IISGSDDGNVRLWRSKAWERSNVKTTREKNKLEYDEKLKERFRHMPEIKRISR 415 Query: 710 H 710 H Sbjct: 416 H 416 Score = 37.6 bits (85), Expect = 0.024, Method: Composition-based stats. Identities = 36/184 (19%), Positives = 67/184 (36%), Gaps = 32/184 (17%) Query: 619 KFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADW---------APLEFGNV 669 L + D W + + F + K H ++ L+ N Sbjct: 81 NKLATGSADGVIKYWNMSTREE-----FVSFKAHYGLVTGLCVTQPRFHDKKPDLKSQNF 135 Query: 670 FVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISV--GLENG 727 ++ S DKTVK+W + + K++ +++ + +IR S G+++ Sbjct: 136 MLSCSDDKTVKLWSINVDDYSN-------KNSSDNDSVTNEEGLIRTFDGESAFQGIDSH 188 Query: 728 EIYLYSYTLGKFELITQLNE-----DIT-PADKITRLRWSHLKRNGKLFLGVGSSDLSTR 781 T G + +N D++ AD IT L+++ +N L SD S Sbjct: 189 RENSTFATGGAKIHLWDVNRLKPVSDLSWGADNITSLKFN---QNETDILASTGSDNSIV 245 Query: 782 IYSL 785 +Y L Sbjct: 246 LYDL 249 Score = 36.0 bits (81), Expect = 0.060, Method: Composition-based stats. Identities = 19/83 (22%), Positives = 39/83 (46%), Gaps = 9/83 (10%) Query: 650 KPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISI 709 K H + D D++P G+ VT S DK++++++ + + HTK + + Sbjct: 302 KDHVSAVMDVDFSP--TGDEIVTGSYDKSIRIYKTNHGHSREIY------HTKRMQHVFQ 353 Query: 710 HDSMIREKILISVGLENGEIYLY 732 + K +IS ++G + L+ Sbjct: 354 VKYSMDSKYIISGS-DDGNVRLW 375 >5OQL-L nrPDB Length = 557 Score = 94.6 bits (233), Expect = 1e-19, Method: Composition-based stats. Identities = 35/247 (14%), Positives = 87/247 (35%), Gaps = 31/247 (12%) Query: 15 NKQTQVSDIHKVKKIVAFGAGK-TIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDS-D 72 + + +I +++ G + ++D + + T H+ V ++ P Sbjct: 99 DSEAHCGEIRPDGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELT 158 Query: 73 FMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP-----SLISVGCADGTIS 127 ++S S+D V++W + ++ + + +P +L+ G D T+ Sbjct: 159 TLMSCSDDKTVRLWDL---PSNDPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVR 215 Query: 128 IWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDS 187 +W + + + LLA G ++V Sbjct: 216 VWDARAPGG--------AVMTFKHADPIEDVLPLPSGTTLLAASGNAISVL--------- 258 Query: 188 GIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEED 247 + + + + H+ V SL+ Q + SGS D +++++ +++ ++ Sbjct: 259 DLVAAKPLRLITNHQKTVTSLSLASQ----GRRVVSGSLDGHVKVFETTSWNVVAGAKYP 314 Query: 248 SKKLTLL 254 S L+L Sbjct: 315 SPILSLS 321 Score = 82.3 bits (201), Expect = 8e-16, Method: Composition-based stats. Identities = 46/277 (16%), Positives = 83/277 (29%), Gaps = 28/277 (10%) Query: 73 FMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQN 132 F V+A V+I+ L+ I + + ++ G G + ++ Sbjct: 73 FAVTAGP--RVEIFSIRKREPLKTIGRFDSEAH-CGEIRPDGRVLVAGEDTGRMQVFDVG 129 Query: 133 IQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKC 192 L T S E + + V + +D Sbjct: 130 QGTRAVIL---KTWHIHKQPVWVTKWSPTELTTLM--SCSDDKTVRLWDLPSNDP----- 179 Query: 193 RVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWR----------IRINDLID 242 GH D+V+ AF + LL SGS D +R+W + D I+ Sbjct: 180 --TRLFTGHTDYVRCGAFMP-GSANSNLLVSGSYDETVRVWDARAPGGAVMTFKHADPIE 236 Query: 243 DSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATAD 302 D TLL+ + D V LI H ++SL ++++ + D Sbjct: 237 DVLPLPSGTTLLAASGNAISVLD--LVAAKPLRLITNHQKTVTSLSLASQGRRVVSGSLD 294 Query: 303 TSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSG 339 + V+E + + +S + Sbjct: 295 GHVKVFETTSWNVVAGAKYPSPILSLSVITAGASHDD 331 Score = 71.1 bits (172), Expect = 2e-12, Method: Composition-based stats. Identities = 48/337 (14%), Positives = 96/337 (28%), Gaps = 74/337 (21%) Query: 86 WKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFT 145 W + S + T S ++VA + L +V + I+ E Sbjct: 42 WPISHISFPASLGTTALVSSSLVAAAKTNDLFAVTAGPR-VEIFSI--------RKREPL 92 Query: 146 IKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWV 205 G F + + L+A G + + + ++ H+ V Sbjct: 93 KTIGRFDSEAHCGEIRPDGRVLVA-GEDTGRMQVFDVGQGTRAV----ILKTWHIHKQPV 147 Query: 206 KSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDD 265 + E L S S D+ +RLW + N Sbjct: 148 WVTKWSPTELTT---LMSCSDDKTVRLWDLPSN--------------------------- 177 Query: 266 ELRVGINFEALIMGHDDWISSLQWHE---SRLQLLAATADTSLMVWEPDETSGIWVCSLR 322 + L GH D++ + + L++ + D ++ VW+ Sbjct: 178 ------DPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDA------------ 219 Query: 323 LGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGIS 382 + GA + L + + A K + I+ Sbjct: 220 ---RAPGGAVMTFKHADPIEDVLPLPSGTTLLAASGNAISVLDLVAAKPLRL------IT 270 Query: 383 GATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDA 419 K VT ++ + G +++ SLD ++F ++ Sbjct: 271 NHQKTVTSLSLASQGRRVVSGSLDGHVKVFETTSWNV 307 Score = 54.5 bits (129), Expect = 2e-07, Method: Composition-based stats. Identities = 33/201 (16%), Positives = 64/201 (31%), Gaps = 16/201 (7%) Query: 562 TCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFL 621 + L + + + V+ IR + + H I DG+ L Sbjct: 61 SSLVAAAKTNDLFAVTAGPRVEIFSIRKREPLKTI-GRFDSEAHCGEIR-----PDGRVL 114 Query: 622 LSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKV 681 ++ + +++ + T + K H + +W W+P E + + S DKTV++ Sbjct: 115 VAGEDTGRMQVFD--VGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLM-SCSDDKTVRL 171 Query: 682 WRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKFEL 741 W HT V + +L+S + + G + Sbjct: 172 WDLPSNDPTRLFT----GHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVM 227 Query: 742 ITQLN---EDITPADKITRLR 759 + ED+ P T L Sbjct: 228 TFKHADPIEDVLPLPSGTTLL 248 Score = 49.9 bits (117), Expect = 4e-06, Method: Composition-based stats. Identities = 40/214 (18%), Positives = 75/214 (35%), Gaps = 17/214 (7%) Query: 560 EITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSK-DG 618 E C +I PD +++ + + +Q + I H + K+S + Sbjct: 101 EAHCGEIRPDGRVLVAGEDTGRMQVFDV---GQGTRAVILKTWHIHKQPVWVTKWSPTEL 157 Query: 619 KFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAP-LEFGNVFVTASRDK 677 L+S D+ LW+ D T HT + + P N+ V+ S D+ Sbjct: 158 TTLMSCSDDKTVRLWDLPSNDPTRLFT-----GHTDYVRCGAFMPGSANSNLLVSGSYDE 212 Query: 678 TVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLG 737 TV+VW + + KH + + S +L + G + L + Sbjct: 213 TVRVWDARAPGG----AVMTFKHADPIEDVLPLPSGTT--LLAASGNAISVLDLVAAKPL 266 Query: 738 KFELITQLN-EDITPADKITRLRWSHLKRNGKLF 770 + Q ++ A + R+ L + K+F Sbjct: 267 RLITNHQKTVTSLSLASQGRRVVSGSLDGHVKVF 300 Score = 47.6 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 17/90 (18%), Positives = 30/90 (33%), Gaps = 9/90 (10%) Query: 10 IFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVP 69 F A+ V + ++A I++ D + + H+ VT + Sbjct: 228 TFKHADPIEDVLPLPSGTTLLAASG-NAISVLDLVAAKPLRLITN---HQKTVTSLSLAS 283 Query: 70 DSDFMVSASEDHHVKI-----WKFTDYSHL 94 +VS S D HVK+ W + Sbjct: 284 QGRRVVSGSLDGHVKVFETTSWNVVAGAKY 313 Score = 44.5 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 49/269 (18%), Positives = 91/269 (33%), Gaps = 34/269 (12%) Query: 378 RLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREI--ATWHEFSRP 435 R ++ P G L+A + T R+ ++D R + TWH +P Sbjct: 97 RFDSEAHCGEI-----RPDGRVLVAG--EDTGRM---QVFDVGQGTRAVILKTWHIHKQP 146 Query: 436 QIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEK--SEMPDSA 493 + T +S D+K +R +DLP L F G + + MP SA Sbjct: 147 ----VWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPTRL--FTGHTDYVRCGAFMPGSA 200 Query: 494 TVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPL----------SLLECPPMEDQLQ 543 + L + + ++ D GG T DP+ +LL + Sbjct: 201 NSNL--LVSGSYDETVRVWDARAPGGAVMTFKHADPIEDVLPLPSGTTLLAASGNAISVL 258 Query: 544 RHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALP 603 + + + H +T L ++ + + S +V+ ++ K P Sbjct: 259 DLVAAKPLRLITNHQKTVTSLSLASQGRRVVSGSLDGHVKVFETTSWNVVAGA--KYPSP 316 Query: 604 FHSLTITRLKFSKDGKFLLSVCRDRKWAL 632 SL++ S D + L + ++ Sbjct: 317 ILSLSVITAGASHDDRHLAVGMQSGVLSI 345 >3CFV-B nrPDB Length = 414 Score = 94.6 bits (233), Expect = 2e-19, Method: Composition-based stats. Identities = 48/259 (18%), Positives = 96/259 (37%), Gaps = 30/259 (11%) Query: 3 ECITPEAIFIGANKQTQVSDIHK--VKKIVAFGAGKTIALWDPI-EPNNKGVY---ATLK 56 EC P+ G K+ + +++ T+ LWD P + A Sbjct: 168 EC-NPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFT 226 Query: 57 GHEAEVTCVRFV--PDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP 114 GH A V V + +S S ++D + IW + + + ++ + LS P Sbjct: 227 GHSAVVEDVAWHLLHES-LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNP 285 Query: 115 S---LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIG 171 +++ G AD T+++W H F K + + S + +LA Sbjct: 286 YSEFILATGSADKTVALWDLRNLK---LKLHTFESHKDEIFQVHWS----PHNETILASS 338 Query: 172 GTNVNVFIASFI-------LSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSG 224 GT+ + + D+ ++ GH + ++ E +++CS Sbjct: 339 GTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEP---WVICSV 395 Query: 225 SQDRYIRLWRIRINDLIDD 243 S+D +++W++ N D+ Sbjct: 396 SEDNIMQIWQMAENIYNDE 414 Score = 91.1 bits (224), Expect = 2e-18, Method: Composition-based stats. Identities = 48/281 (17%), Positives = 95/281 (33%), Gaps = 52/281 (18%) Query: 42 DPIEPNNKGVYATLKGHEAEVTCVRFVPD-SDFMVSASEDHHVKIWKFTDYSHLQCIQT- 99 DP N + L+GH+ E + + + S ++SAS+DH V +W I Sbjct: 164 DPSGECNPDL--RLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDA 221 Query: 100 ---IQHYSKTIVALSA---LPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYP 153 +S + ++ SL D + IW + Sbjct: 222 KAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRS---NTTSKPSHLVDAHTAEV 278 Query: 154 LCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRV-VAELEGHEDWVKSLAFRH 212 CLS + E ++LA G + V + + ++ + E H+D + + + Sbjct: 279 NCLSFNPYSE--FILATGSADKTVALW-------DLRNLKLKLHTFESHKDEIFQVHWSP 329 Query: 213 QETPGDYLLCSGSQDRYIRLWRIR---INDLIDDSEEDSKKLTLLSNKQYKFQIDDELRV 269 +L S DR + +W + +D+E+ +L + Sbjct: 330 HNET---ILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHG------------- 373 Query: 270 GINFEALIMGHDDWISSLQWHESRLQLL-AATADTSLMVWE 309 GH IS W+ + ++ + + D + +W+ Sbjct: 374 ---------GHTAKISDFSWNPNEPWVICSVSEDNIMQIWQ 405 Score = 71.1 bits (172), Expect = 2e-12, Method: Composition-based stats. Identities = 44/320 (13%), Positives = 93/320 (29%), Gaps = 61/320 (19%) Query: 135 NDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGI-EKCR 193 E + HE + + + P ++V VF + + +C Sbjct: 118 ECEIKINHEGEVNRARYMPQ-------NPHIIATKTPSSDVLVFDYTKHPAKPDPSGECN 170 Query: 194 VVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRI----------NDLIDD 243 L GH+ L++ + L S S D + LW I + Sbjct: 171 PDLRLRGHQKEGYGLSWN---SNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTG 227 Query: 244 SEEDSKKLTL----------LSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESR 293 + + +++ Q D L+ H ++ L ++ Sbjct: 228 HSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYS 287 Query: 294 LQLL-AATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERM 352 +L +AD ++ +W+ L + K + + W H Sbjct: 288 EFILATGSADKTVALWD-------------LRNLKLKLHTFE-SHKDEIFQVHWSPHN-E 332 Query: 353 DFFLTNGKTGSWRMWATKDNIICDQR-----------LGISGATKDVTDIAWSPSGEY-L 400 ++G +W G T ++D +W+P+ + + Sbjct: 333 TILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVI 392 Query: 401 LATSLDQTTRLF--APWIYD 418 + S D +++ A IY+ Sbjct: 393 CSVSEDNIMQIWQMAENIYN 412 Score = 68.8 bits (166), Expect = 9e-12, Method: Composition-based stats. Identities = 38/202 (18%), Positives = 73/202 (36%), Gaps = 24/202 (11%) Query: 272 NFEALIMGHDDWISSLQWHES-RLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKG 330 N + + GH L W+ + LL+A+ D ++ +W+ + E Sbjct: 170 NPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINA---------GPKEGKIVD 220 Query: 331 ASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTD 390 A + + F + +W T+ N + T +V Sbjct: 221 AKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNC 280 Query: 391 IAWSPSGEYLL-ATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVE--T 447 ++++P E++L S D+T L +D K ++ H F + H ++ V Sbjct: 281 LSFNPYSEFILATGSADKTVAL-----WDLRNLKLKL---HTF---ESHKDEIFQVHWSP 329 Query: 448 VTDTRFVSGGDEKILRSFDLPK 469 +T S G ++ L +DL K Sbjct: 330 HNETILASSGTDRRLNVWDLSK 351 Score = 54.5 bits (129), Expect = 2e-07, Method: Composition-based stats. Identities = 32/149 (21%), Positives = 57/149 (38%), Gaps = 17/149 (11%) Query: 554 LYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLK 613 + H E+ CL +P + I + + + + ++ N H I ++ Sbjct: 271 VDAHTAEVNCLSFNPYSEFILATGSA----DKTVALWDLRNLKLKLHTFESHKDEIFQVH 326 Query: 614 FSK-DGKFLLSVCRDRKWALWE----------RNMEDNTFELRFKNEKPHTRIIWDADWA 662 +S + L S DR+ +W+ + ED EL F HT I D W Sbjct: 327 WSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFI-HGGHTAKISDFSWN 385 Query: 663 PLEFGNVFVTASRDKTVKVWRHQKEPADD 691 P E V + S D +++W+ + +D Sbjct: 386 PNE-PWVICSVSEDNIMQIWQMAENIYND 413 Score = 46.0 bits (107), Expect = 6e-05, Method: Composition-based stats. Identities = 32/191 (16%), Positives = 62/191 (32%), Gaps = 18/191 (9%) Query: 590 FSTENWLEIKPALPFHSLTITRLKFSKD-GKFLLSVCRDRKWALWERNMEDNTFELRFKN 648 L H L ++ + LLS D LW+ N ++ Sbjct: 163 PDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAK 222 Query: 649 E--KPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTA 706 H+ ++ D W L ++F + + D+ + +W + HT V Sbjct: 223 AIFTGHSAVVEDVAWHLLH-ESLFGSVADDQKLMIWDTRSNTTSKPS-HLVDAHTAEVNC 280 Query: 707 ISIHD-------SMIREKILISVGLENGEIYLY---SYTLGKFELITQLNEDITPADKIT 756 +S + + +K + L N ++ L+ S+ F++ + + A T Sbjct: 281 LSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGT 340 Query: 757 RLR---WSHLK 764 R W K Sbjct: 341 DRRLNVWDLSK 351 >5Y1U-A nrPDB Length = 456 Score = 94.2 bits (232), Expect = 2e-19, Method: Composition-based stats. Identities = 47/278 (16%), Positives = 95/278 (34%), Gaps = 46/278 (16%) Query: 42 DPIEPNNKGVYATLKGHEAEVTCVRFVPD-SDFMVSASEDHHVKIWKFTDYSHLQCIQT- 99 DP N + L+GH+ E + + P+ S ++SAS+DH + +W + + Sbjct: 193 DPSGECNPDL--RLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDA 250 Query: 100 ---IQHYSKTIVALSA---LPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYP 153 ++ + +S SL D + IW N ++ Sbjct: 251 KTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSH---SVDAHTAEV 307 Query: 154 LCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRV-VAELEGHEDWVKSLAFRH 212 CLS + E ++LA G + V + + ++ + E H+D + + + Sbjct: 308 NCLSFNPYSE--FILATGSADKTVALW-------DLRNLKLKLHSFESHKDEIFQVQWSP 358 Query: 213 QETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGIN 272 +L S DR + +W + I + + + Sbjct: 359 HNET---ILASSGTDRRLNVWDLS---KIGEEQSPEDAEDGPPELLFIHG---------- 402 Query: 273 FEALIMGHDDWISSLQWHESRLQLL-AATADTSLMVWE 309 GH IS W+ + ++ + + D + VW+ Sbjct: 403 ------GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 434 Score = 93.0 bits (229), Expect = 4e-19, Method: Composition-based stats. Identities = 50/264 (18%), Positives = 96/264 (36%), Gaps = 30/264 (11%) Query: 3 ECITPEAIFIGANKQTQVSDIHK--VKKIVAFGAGKTIALWD----PIEPNNKGVYATLK 56 EC P+ G K+ + +++ TI LWD P E Sbjct: 197 EC-NPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFT 255 Query: 57 GHEAEVTCVRFV--PDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP 114 GH A V V + +S S ++D + IW + + ++ ++ + LS P Sbjct: 256 GHTAVVEDVSWHLLHES-LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP 314 Query: 115 S---LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIG 171 +++ G AD T+++W H F K + + +LA Sbjct: 315 YSEFILATGSADKTVALWDLRNLK---LKLHSFESHK----DEIFQVQWSPHNETILASS 367 Query: 172 GTNVNVFIASFI-------LSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSG 224 GT+ + + D+ ++ GH + ++ E +++CS Sbjct: 368 GTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEP---WVICSV 424 Query: 225 SQDRYIRLWRIRINDLIDDSEEDS 248 S+D +++W++ N D+ E S Sbjct: 425 SEDNIMQVWQMAENIYNDEDPEGS 448 Score = 71.5 bits (173), Expect = 1e-12, Method: Composition-based stats. Identities = 46/320 (14%), Positives = 96/320 (30%), Gaps = 65/320 (20%) Query: 137 EFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGI---EKCR 193 E + HE + + + P ++A + +V + + S +C Sbjct: 149 EIKINHEGEVNRARYMPQ---------NPCIIATKTPSSDVLVFDYTKHPSKPDPSGECN 199 Query: 194 VVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRI----------NDLIDD 243 L GH+ L++ + L S S D I LW I + Sbjct: 200 PDLRLRGHQKEGYGLSWNPNLSGH---LLSASDDHTICLWDISAVPKEGKVVDAKTIFTG 256 Query: 244 SEEDSKKLTL---------LSNKQYKFQIDDELRVGI-NFEALIMGHDDWISSLQWHESR 293 + ++ K I D + H ++ L ++ Sbjct: 257 HTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS 316 Query: 294 LQLL-AATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERM 352 +L +AD ++ +W+ L + K S + W H Sbjct: 317 EFILATGSADKTVALWD-------------LRNLKLKLHSFE-SHKDEIFQVQWSPHN-E 361 Query: 353 DFFLTNGKTGSWRMWATK-----------DNIICDQRLGISGATKDVTDIAWSPSGEY-L 400 ++G +W ++ + G T ++D +W+P+ + + Sbjct: 362 TILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVI 421 Query: 401 LATSLDQTTRLF--APWIYD 418 + S D +++ A IY+ Sbjct: 422 CSVSEDNIMQVWQMAENIYN 441 Score = 69.9 bits (169), Expect = 5e-12, Method: Composition-based stats. Identities = 40/202 (19%), Positives = 75/202 (37%), Gaps = 24/202 (11%) Query: 272 NFEALIMGHDDWISSLQWHES-RLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKG 330 N + + GH L W+ + LL+A+ D ++ +W+ S E Sbjct: 199 NPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDI---------SAVPKEGKVVD 249 Query: 331 ASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTD 390 A T + + F + +W T+ N + T +V Sbjct: 250 AKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNC 309 Query: 391 IAWSPSGEYLL-ATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVE--T 447 ++++P E++L S D+T L +D K ++ H F + H ++ V+ Sbjct: 310 LSFNPYSEFILATGSADKTVAL-----WDLRNLKLKL---HSF---ESHKDEIFQVQWSP 358 Query: 448 VTDTRFVSGGDEKILRSFDLPK 469 +T S G ++ L +DL K Sbjct: 359 HNETILASSGTDRRLNVWDLSK 380 Score = 55.3 bits (131), Expect = 9e-08, Method: Composition-based stats. Identities = 36/180 (20%), Positives = 64/180 (35%), Gaps = 12/180 (6%) Query: 549 PEVEKLYGHGFEITCLDISPDQKL-IASACRSNNVQNAVIR-IFSTENWLEIKPALPFHS 606 P++ L GH E L +P+ + SA + + I + ++ K H+ Sbjct: 200 PDLR-LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHT 258 Query: 607 LTITRLKFSKDGKFLL-SVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLE 665 + + + + L SV D+K +W+ N + HT + + P Sbjct: 259 AVVEDVSWHLLHESLFGSVADDQKLMIWDTRS--NNTSKPSHSVDAHTAEVNCLSFNP-Y 315 Query: 666 FGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLE 725 + T S DKTV +W + L + H + + E IL S G + Sbjct: 316 SEFILATGSADKTVALWDLRN---LKLKLHSFESHKDEIFQVQWSPH--NETILASSGTD 370 Score = 53.8 bits (127), Expect = 3e-07, Method: Composition-based stats. Identities = 35/156 (22%), Positives = 62/156 (39%), Gaps = 17/156 (10%) Query: 554 LYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLK 613 + H E+ CL +P + I + + + + ++ N + H I +++ Sbjct: 300 VDAHTAEVNCLSFNPYSEFILATGSA----DKTVALWDLRNLKLKLHSFESHKDEIFQVQ 355 Query: 614 FSK-DGKFLLSVCRDRKWALWE----------RNMEDNTFELRFKNEKPHTRIIWDADWA 662 +S + L S DR+ +W+ + ED EL F HT I D W Sbjct: 356 WSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFI-HGGHTAKISDFSWN 414 Query: 663 PLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASI 698 P E V + S D ++VW+ + +D E S+ Sbjct: 415 PNE-PWVICSVSEDNIMQVWQMAENIYNDEDPEGSV 449 Score = 32.2 bits (71), Expect = 0.96, Method: Composition-based stats. Identities = 50/279 (17%), Positives = 96/279 (34%), Gaps = 47/279 (16%) Query: 375 CDQRLGISGATKDVTDIAWSPS-GEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFS 433 C+ L + G K+ ++W+P+ +LL+ S D T L+ G+ + T F+ Sbjct: 198 CNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTI--FT 255 Query: 434 RPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSA 493 D+ + ++ F S D++ L +D + S D+ Sbjct: 256 GHTAVVEDVSW-HLLHESLFGSVADDQKLMIWDTRSN-----------NTSKPSHSVDAH 303 Query: 494 TVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEK 553 T V LS N + I S + + D L ++ Sbjct: 304 TAEVNCLSF-----------------NPYSEFILATGSADKTVALWDLRNLKL---KLHS 343 Query: 554 LYGHGFEITCLDISP-DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALP--------F 604 H EI + SP ++ ++AS+ + + E E P Sbjct: 344 FESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGG 403 Query: 605 HSLTITRLKFSKDGKFLL-SVCRDRKWALWERNMEDNTF 642 H+ I+ ++ + +++ SV D +W M +N + Sbjct: 404 HTAKISDFSWNPNEPWVICSVSEDNIMQVW--QMAENIY 440 >5L9T-R nrPDB Length = 493 Score = 93.4 bits (230), Expect = 3e-19, Method: Composition-based stats. Identities = 41/216 (18%), Positives = 77/216 (35%), Gaps = 28/216 (12%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVK 84 +++ + + I D I L+GH EV +++ D + S D+ + Sbjct: 280 NAEQLSSGSRDRMILQRD-IRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLL 338 Query: 85 IWKFTDYSHLQCIQTIQHYSKTIVALSALPS---LISVGCA--DGTISIWRQNIQNDEFG 139 +W ++S L +Q + + A++ P L++ G D I W Sbjct: 339 VW---NHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQP--- 392 Query: 140 LAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELE 199 L T + L+ SK + + G + + + + VA+L Sbjct: 393 LQCIDTGSQV----CNLAWSKHA-NELVSTHGYSQNQILVWKYP-------SLTQVAKLT 440 Query: 200 GHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI 235 GH V LA P + +G+ D +R W + Sbjct: 441 GHSYRVLYLAMS----PDGEAIVTGAGDETLRFWNV 472 Score = 90.0 bits (221), Expect = 4e-18, Method: Composition-based stats. Identities = 50/296 (16%), Positives = 100/296 (33%), Gaps = 39/296 (13%) Query: 29 IVAFGAGKTIALWDPIEPN-NKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWK 87 +++ G G + LW + +++G VT V + + + + V+IW Sbjct: 200 VLSVGLGTCVYLWSACTSQVTRLCDLSVEG--DSVTSVGWSERGNLVAVGTHKGFVQIW- 256 Query: 88 FTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIK 147 D + + + ++ ++ + AL+ +S G D I +++I+ Sbjct: 257 --DAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMIL--QRDIRTPPLQSERRLQGH 312 Query: 148 KGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKS 207 + + K LLA GG + + + + V + H VK+ Sbjct: 313 R-----QEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSP-------VQQYTEHLAAVKA 360 Query: 208 LAFRHQETPGDYLLCSGS--QDRYIRLWRIRINDLIDDSEEDSKKLTLLSNK-------- 257 +A+ + LL SG DR IR W + + S+ L +K Sbjct: 361 IAWSPHQ---HGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVST 417 Query: 258 ----QYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWE 309 Q + + + A + GH + L ++ D +L W Sbjct: 418 HGYSQNQILVWK--YPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 471 Score = 79.6 bits (194), Expect = 5e-15, Method: Composition-based stats. Identities = 60/375 (16%), Positives = 106/375 (28%), Gaps = 81/375 (21%) Query: 65 VRFVPDSDFMVSASEDHHVKIWKFTDYSHLQ-CIQTIQHYSKTIVALSALPSLISVGCAD 123 V + + ++S V +W + C +++ S T V S +L++VG Sbjct: 193 VDWSSLN--VLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHK 250 Query: 124 GTISIWRQNIQND-EFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASF 182 G + IW H + + LS G + + Sbjct: 251 GFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQLS------------SGSRDRMIL---- 294 Query: 183 ILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLID 242 D + L+GH V L + LL SG D + +W Sbjct: 295 -QRDIRTPPLQSERRLQGHRQEVCGLKWS----TDHQLLASGGNDNKLLVWNHS------ 343 Query: 243 DSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLA---A 299 +L +QY H + ++ W + LLA Sbjct: 344 ---------SLSPVQQYTE------------------HLAAVKAIAWSPHQHGLLASGGG 376 Query: 300 TADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNG 359 TAD + W + + W H Sbjct: 377 TADRCIRFWNTLTGQPLQCIDTGSQVCNL----------------AWSKHANELVSTHGY 420 Query: 360 KTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDA 419 +W Q ++G + V +A SP GE ++ + D+T R + + Sbjct: 421 SQNQILVWKYPS---LTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFS-KT 476 Query: 420 SGRKREIATWHEFSR 434 K ++ + F+R Sbjct: 477 RSTKESVSVLNLFTR 491 Score = 55.3 bits (131), Expect = 1e-07, Method: Composition-based stats. Identities = 43/248 (17%), Positives = 85/248 (34%), Gaps = 33/248 (13%) Query: 550 EVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTI 609 ++ L GH + L + +Q ++S R + IR L+ + L H + Sbjct: 263 KLSMLEGHTARVGALAWNAEQ--LSSGSRDRMILQRDIRTP----PLQSERRLQGHRQEV 316 Query: 610 TRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNV 669 LK+S D + L S D K +W +++ + H + W+P + G + Sbjct: 317 CGLKWSTDHQLLASGGNDNKLLVW-----NHSSLSPVQQYTEHLAAVKAIAWSPHQHGLL 371 Query: 670 FV-TASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGE 728 + D+ ++ W + S V ++ S +++ + G + Sbjct: 372 ASGGGTADRCIRFWNTLTGQPLQCIDTGS-----QVCNLAW--SKHANELVSTHGYSQNQ 424 Query: 729 I------------YLYSYTLGKFELITQLNED--ITPADKITRLRWSHLKRNGKLFLGVG 774 I L ++ L + + +T A T W+ + V Sbjct: 425 ILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKESVS 484 Query: 775 SSDLSTRI 782 +L TRI Sbjct: 485 VLNLFTRI 492 Score = 49.1 bits (115), Expect = 6e-06, Method: Composition-based stats. Identities = 41/335 (12%), Positives = 97/335 (28%), Gaps = 77/335 (22%) Query: 260 KFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVC 319 + + + D ++S+ W E + T + +W+ + + Sbjct: 208 CVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSML 267 Query: 320 SLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRL 379 G + + W + + + + + +R Sbjct: 268 E---------------GHTARVGALAWNAEQLS----SGSRDRMILQRDIRTPPLQSER- 307 Query: 380 GISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHG 439 + G ++V + WS + L + D +++ S S Q + Sbjct: 308 RLQGHRQEVCGLKWSTDHQLLASGGNDNKL-----LVWNHS----------SLSPVQQYT 352 Query: 440 YDMICVETVTDT-----RFVSGGD--EKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDS 492 + V+ + + SGG ++ +R ++ G + + Sbjct: 353 EHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTG-------------QPLQCIDTG 399 Query: 493 ATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVE 552 + V L S A E + + + + P +T +V Sbjct: 400 SQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLT----------------------QVA 437 Query: 553 KLYGHGFEITCLDISPDQKLIASACRSNNVQNAVI 587 KL GH + + L +SPD + I + ++ + Sbjct: 438 KLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNV 472 Score = 39.1 bits (89), Expect = 0.008, Method: Composition-based stats. Identities = 30/177 (16%), Positives = 58/177 (32%), Gaps = 21/177 (11%) Query: 608 TITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFG 667 ++T + +S+ G + +W+ L + HT + W Sbjct: 231 SVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSML-----EGHTARVGALAWNA---- 281 Query: 668 NVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENG 727 + SRD+ + + P H + V + ++L S G +N Sbjct: 282 EQLSSGSRDRMILQRDIRTPPLQSE--RRLQGHRQEVCGLKWS---TDHQLLASGGNDN- 335 Query: 728 EIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYS 784 L + + Q E + I WS ++G L G G++D R ++ Sbjct: 336 --KLLVWNHSSLSPVQQYTEHLAAVKAIA---WS-PHQHGLLASGGGTADRCIRFWN 386 >5G04-R nrPDB Length = 499 Score = 92.7 bits (228), Expect = 6e-19, Method: Composition-based stats. Identities = 62/369 (16%), Positives = 114/369 (30%), Gaps = 76/369 (20%) Query: 65 VRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTI-QHYSKTIVALSALPSLISVGCAD 123 V + + V+ D+ V +W + LQ +Q + VA + ++VG + Sbjct: 190 VDWSSGNVLAVA--LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 247 Query: 124 GTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFI 183 + +W Q + LS Y+L+ G + ++ Sbjct: 248 AEVQLWDVQQQKRL------RNMTSHSARVGSLSW-----NSYILSSGSRSGHIHHHDVR 296 Query: 184 LSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDD 243 +++ VA L GH V L + P L SG D + +W + Sbjct: 297 VAEHH------VATLSGHSQEVCGLRWA----PDGRHLASGGNDNLVNVWPSAPGE---- 342 Query: 244 SEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLA---AT 300 L+ H + ++ W + +LA T Sbjct: 343 ------------------GGWVPLQTFTQ-------HQGAVKAVAWCPWQSNVLATGGGT 377 Query: 301 ADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGK 360 +D + +W + + A + S LW H + Sbjct: 378 SDRHIRIWNVCSGACLS----------------AVDAHSQVCSILWSPHYKELISGHGFA 421 Query: 361 TGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYD-A 419 +W + + G T V + SP G + + + D+T RL+ + D A Sbjct: 422 QNQLVIWKYPTMAKVAE---LKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPA 478 Query: 420 SGRKREIAT 428 R+RE A+ Sbjct: 479 RRREREKAS 487 Score = 92.3 bits (227), Expect = 7e-19, Method: Composition-based stats. Identities = 46/300 (15%), Positives = 105/300 (35%), Gaps = 34/300 (11%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVK 84 ++A ++ LW + + ++ ++ V ++ + +++ + V+ Sbjct: 193 SSGNVLAVALDNSVYLWSASSGDILQLLQ-MEQPGEYISSVAWIKEGNYLAVGTSSAEVQ 251 Query: 85 IWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEF 144 +W D + ++ + +S + +LS ++S G G I + E Sbjct: 252 LW---DVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHI--------HHHDVRVAEH 300 Query: 145 TIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDW 204 + + + + LA GG + V + S G + H+ Sbjct: 301 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWP---SAPGEGGWVPLQTFTQHQGA 357 Query: 205 VKSLAFRHQETPGDYLLCSGS--QDRYIRLWRI----------RINDLIDDSEEDSKKLT 252 VK++A+ ++ +L +G DR+IR+W + + + K Sbjct: 358 VKAVAWCPWQSN---VLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKEL 414 Query: 253 LLSNK--QYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEP 310 + + Q + I + E + GH + SL + +A AD +L +W Sbjct: 415 ISGHGFAQNQLVIWKYPTMAKVAE--LKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 472 Score = 62.2 bits (149), Expect = 7e-10, Method: Composition-based stats. Identities = 27/194 (13%), Positives = 59/194 (30%), Gaps = 22/194 (11%) Query: 9 AIFIGAN-KQTQVSDIHKVKKIVAFGAGKTIALW-DPIEPNNKGVYATLKGHEAEVTCVR 66 A G + + + + + + G + +W T H+ V V Sbjct: 303 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 362 Query: 67 FVP-DSDFMVSAS--EDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSL--ISVGC 121 + P S+ + + D H++IW + C+ + +S+ ++ P + G Sbjct: 363 WCPWQSNVLATGGGTSDRHIRIWNVCSGA---CLSAVDAHSQVC-SILWSPHYKELISGH 418 Query: 122 A--DGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFI 179 + IW+ E LSL+ + +A + + + Sbjct: 419 GFAQNQLVIWK----YPTMAKVAELKGHTSRV----LSLTMSPDGA-TVASAAADETLRL 469 Query: 180 ASFILSDSGIEKCR 193 D + R Sbjct: 470 WRCFELDPARRRER 483 Score = 58.4 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 41/313 (13%), Positives = 95/313 (30%), Gaps = 46/313 (14%) Query: 173 TNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIR- 231 + + L+ +E+ +++ L G + GS + R Sbjct: 109 KKEHQKAWALNLNGFDVEEAKIL-RLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRY 167 Query: 232 -------------LWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIM 278 + +L+D S + + L + I + Sbjct: 168 IPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVAL----DNSVYLWSASSGDILQLLQME 223 Query: 279 GHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSS 338 ++ISS+ W + L T+ + +W+ K T S Sbjct: 224 QPGEYISSVAWIKEGNYLAVGTSSAEVQLWDV---------------QQQKRLRNMTSHS 268 Query: 339 GGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGE 398 S W ++ + ++G + + +SG +++V + W+P G Sbjct: 269 ARVGSLSWNSY----ILSSGSRSGHIHHHDVR--VAEHHVATLSGHSQEVCGLRWAPDGR 322 Query: 399 YLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGG- 457 +L + D ++ A G + F++ Q + ++ GG Sbjct: 323 HLASGGNDNLVNVWP----SAPGEGGWVP-LQTFTQHQGAVKAVAWCPWQSNVLATGGGT 377 Query: 458 DEKILRSFDLPKG 470 ++ +R +++ G Sbjct: 378 SDRHIRIWNVCSG 390 Score = 53.0 bits (125), Expect = 5e-07, Method: Composition-based stats. Identities = 29/186 (15%), Positives = 72/186 (38%), Gaps = 18/186 (9%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 + + H + L + +++S RS ++ + +R+ E+ + L HS + Sbjct: 261 LRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRV--AEHHV---ATLSGHSQEVC 313 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVF 670 L+++ DG+ L S D +W + + + + H + W P + NV Sbjct: 314 GLRWAPDGRHLASGGNDNLVNVWPSAPGEGGW-VPLQTFTQHQGAVKAVAWCPWQS-NVL 371 Query: 671 VT--ASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGE 728 T + D+ +++W +++ V +I ++++ G + Sbjct: 372 ATGGGTSDRHIRIWNVCSGA-----CLSAVDAHSQVCSILWSPHY--KELISGHGFAQNQ 424 Query: 729 IYLYSY 734 + ++ Y Sbjct: 425 LVIWKY 430 Score = 53.0 bits (125), Expect = 6e-07, Method: Composition-based stats. Identities = 58/361 (16%), Positives = 114/361 (31%), Gaps = 78/361 (21%) Query: 280 HDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSG 339 +D +++ + W +LA D S+ +W + + + G Sbjct: 183 NDYYLNLVDWSSGN--VLAVALDNSVYLWSASSGDILQLLQMEQP--------------G 226 Query: 340 GFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEY 399 + S + + E ++ + ++W + ++ + V ++W Y Sbjct: 227 EYISSVAWIKEG-NYLAVGTSSAEVQLWDVQQQKRLR---NMTSHSARVGSLSW---NSY 279 Query: 400 LLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTR-FVSGGD 458 +L++ +R +D + +AT H ++ + D R SGG+ Sbjct: 280 ILSSG----SRSGHIHHHDVRVAEHHVATL------SGHSQEVCGLRWAPDGRHLASGGN 329 Query: 459 EKILRSFDLPKGVAGM--LQKFVGIQFEEKSEM--PDSATVPVLGLSNKAGEDDANEDDE 514 + ++ + G G LQ F Q K+ P + V L+ G D + Sbjct: 330 DNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV----LATGGGTSDRH---- 381 Query: 515 EEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKL-YGHGFEITCLDISPDQKLI 573 ++ + L Q+ L P ++L GHGF Sbjct: 382 ------IRIWNVCS-GACLSAVDAHSQVCSILWSPHYKELISGHGF-------------- 420 Query: 574 ASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALW 633 QN ++ + L H+ + L S DG + S D LW Sbjct: 421 --------AQNQLVIWK--YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 Query: 634 E 634 Sbjct: 471 R 471 Score = 45.3 bits (105), Expect = 1e-04, Method: Composition-based stats. Identities = 30/206 (14%), Positives = 69/206 (33%), Gaps = 20/206 (9%) Query: 581 NVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDN 640 + N+V ++ + + I+ + + K+G +L + LW+ + Sbjct: 201 ALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQK- 259 Query: 641 TFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKH 700 R +N H+ + W + + SR + + ++ + H Sbjct: 260 ----RLRNMTSHSARVGSLSW----NSYILSSGSRSGHIHHHDVR---VAEHHVATLSGH 308 Query: 701 TKAVTAISIHDSMIREKILISVGLENGEIYLYSY-TLGKFELITQLNEDITPADKITRLR 759 ++ V + + L S G +N S G + + + + Sbjct: 309 SQEVCGLRWAPDG---RHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 365 Query: 760 WSHLKRNGKLFLGVGSSDLSTRIYSL 785 W ++ L G G+SD RI+++ Sbjct: 366 W----QSNVLATGGGTSDRHIRIWNV 387 >5WJC-A nrPDB Length = 430 Score = 91.9 bits (226), Expect = 9e-19, Method: Composition-based stats. Identities = 43/224 (19%), Positives = 81/224 (36%), Gaps = 28/224 (12%) Query: 29 IVAFGAGKTIALWDP-------IEPNNKGVYATLKGHEAEVTCVRFVPDSD-FMVSASED 80 + + I LWD E A H V V+F P + + S S+D Sbjct: 198 LATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEALLASVSDD 257 Query: 81 HHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP---SLISVGCADGTISIWRQNIQNDE 137 ++I + + IQ +SK I A++ P L++ AD T+++W + Sbjct: 258 CTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALWDL---RNP 314 Query: 138 FGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASF-------ILSDSGIE 190 + H + Y L S + +LA T+ V I D+ Sbjct: 315 YQRLHTLEGHEDEVYGLEWS----PHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDG 370 Query: 191 KCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWR 234 ++ GH + + ++ E +++ S + D +++W Sbjct: 371 SPELLFMHGGHTNRISEFSWCPNER---WVVGSLADDNILQIWS 411 Score = 91.9 bits (226), Expect = 1e-18, Method: Composition-based stats. Identities = 51/298 (17%), Positives = 92/298 (30%), Gaps = 49/298 (16%) Query: 42 DPIEPNNKGVYATLKGHEAEVTCVRFVPDSD-FMVSASEDHHVKIWKFTDY-------SH 93 D + A LKGH AE + + P+ + + +ED + +W Sbjct: 165 DALTTGEALPQAVLKGHTAEGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKV 224 Query: 94 LQCIQTIQHYSKTIVALSALPS---LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGF 150 + I ++ + + P L++ D T+ I + +E K Sbjct: 225 ISPIAKYHRHTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAI 284 Query: 151 FYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAF 210 + YLLA + V + + + LEGHED V L + Sbjct: 285 NAVAINPFND-----YLLATASADKTVALWDLR------NPYQRLHTLEGHEDEVYGLEW 333 Query: 211 RHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVG 270 + +L S S DR + +W + + I + + + Sbjct: 334 SPH---DEPILASSSTDRRVCIWDL---EKIGEEQTPEDAEDGSPELLFMHG-------- 379 Query: 271 INFEALIMGHDDWISSLQWHESRLQLL-AATADTSLMVWEPD----ETSGIWVCSLRL 323 GH + IS W + ++ + D L +W P + V L Sbjct: 380 --------GHTNRISEFSWCPNERWVVGSLADDNILQIWSPSRVIWGRDHVQVSPRDL 429 Score = 79.6 bits (194), Expect = 5e-15, Method: Composition-based stats. Identities = 32/135 (23%), Positives = 48/135 (35%), Gaps = 19/135 (14%) Query: 13 GANKQTQVSDIH--KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVP- 69 +K I+ + A KT+ALWD N TL+GHE EV + + P Sbjct: 279 AHSKAINAVAINPFNDYLLATASADKTVALWDL--RNPYQRLHTLEGHEDEVYGLEWSPH 336 Query: 70 DSDFMVSASEDHHVKIWKFTDYSHLQCIQT-----------IQHYSKTIVALSALPS--- 115 D + S+S D V IW Q + ++ I S P+ Sbjct: 337 DEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPNERW 396 Query: 116 LISVGCADGTISIWR 130 ++ D + IW Sbjct: 397 VVGSLADDNILQIWS 411 Score = 64.5 bits (155), Expect = 2e-10, Method: Composition-based stats. Identities = 60/323 (18%), Positives = 114/323 (35%), Gaps = 52/323 (16%) Query: 160 KVEEKKYLLAIGGTNVNVFIASFILSDS-GIEKCRVVAELEGHEDWVKSLAFRHQETPGD 218 + +K ++A G N +I D+ + A L+GH L + PG+ Sbjct: 139 YMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLCWNP-NLPGN 197 Query: 219 YLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIM 278 L +G++D+ I LW ++ E +V I+ A Sbjct: 198 --LATGAEDQVICLWDVQTQS----------------------FTSSETKV-ISPIAKYH 232 Query: 279 GHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSS 338 H D ++ +Q+H LLA+ +D + D + ++ + SK + + Sbjct: 233 RHTDIVNDVQFHPQHEALLASVSD-DCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAIN- 290 Query: 339 GGFWSCLWFTHERMDFFL-TNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSG 397 D+ L T + +W ++ + + G +V + WSP Sbjct: 291 -----------PFNDYLLATASADKTVALWDLRN--PYQRLHTLEGHEDEVYGLEWSPHD 337 Query: 398 EYLLATSLDQTTRLFAPWIYDASGRKR-----EIATWHEFSRPQIHGYDMICVETVTDTR 452 E +LA+S T R W + G ++ E + H + + R Sbjct: 338 EPILASS--STDRRVCIWDLEKIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPNER 395 Query: 453 FVSG--GDEKILRSFDLPKGVAG 473 +V G D+ IL+ + + + G Sbjct: 396 WVVGSLADDNILQIWSPSRVIWG 418 Score = 46.0 bits (107), Expect = 6e-05, Method: Composition-based stats. Identities = 52/249 (20%), Positives = 83/249 (33%), Gaps = 46/249 (18%) Query: 517 EGGNKETPDIT--DPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPD-QKLI 573 EGGN D T D L+ E P L GH E L +P+ + Sbjct: 152 EGGNAYIFDTTCHDALTTGEALPQA-------------VLKGHTAEGFGLCWNPNLPGNL 198 Query: 574 ASACRSNNVQNAVIRIFSTENWLEIKPALPF-----HSLTITRLKFSKDGK-FLLSVCRD 627 A+ + ++ + E K P H+ + ++F + L SV D Sbjct: 199 ATGAEDQVICLWDVQT-QSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEALLASVSDD 257 Query: 628 RKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKE 687 + + + N E K + H++ I P + TAS DKTV +W + Sbjct: 258 CTLQIHDTRL--NPEEEAPKVIQAHSKAINAVAINPFN-DYLLATASADKTVALWDLRNP 314 Query: 688 PADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKFELIT---Q 744 + LE H V + + E L S + + I + Sbjct: 315 YQRLHTLE---GHEDEVYGLEWSP--------------HDEPILASSSTDRRVCIWDLEK 357 Query: 745 LNEDITPAD 753 + E+ TP D Sbjct: 358 IGEEQTPED 366 Score = 32.6 bits (72), Expect = 0.78, Method: Composition-based stats. Identities = 18/93 (19%), Positives = 37/93 (39%), Gaps = 10/93 (10%) Query: 551 VEKLYGHGFEITCLDISP-DQKLIASACRSNNVQNAVIRIFSTE--------NWLEIKPA 601 + L GH E+ L+ SP D+ ++AS+ V + E E+ Sbjct: 318 LHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDGSPELLFM 377 Query: 602 LPFHSLTITRLKFSKDGKFLL-SVCRDRKWALW 633 H+ I+ + + ++++ S+ D +W Sbjct: 378 HGGHTNRISEFSWCPNERWVVGSLADDNILQIW 410 >5K0Y-T nrPDB Length = 329 Score = 91.5 bits (225), Expect = 1e-18, Method: Composition-based stats. Identities = 37/328 (11%), Positives = 95/328 (28%), Gaps = 67/328 (20%) Query: 55 LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVAL--SA 112 L+GHE +T +++ + D + + ++D V +W + + + T ++ + + Sbjct: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNG---ERLGTYMGHTGAVWCVDADW 62 Query: 113 LPSLISVGCADGTISIWRQNIQNDEF---------GLAHEFTIKK--------------G 149 + G AD + +W +F Sbjct: 63 DTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFV 122 Query: 150 FFYPLCLSLSKVEEKKYL-LAIGGTNVNVFIA------------SFILSDSGIEKCRVVA 196 F+ L + Y+ + + + + S L+ + V+ Sbjct: 123 SFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLV 182 Query: 197 ELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRIND--LIDDSEEDSKKLTLL 254 ++ H + + + T + + S+D +L+ + +E + L Sbjct: 183 NVKEHSRQINDIQLSREMT----MFVTASKDNTAKLFDSTTLEHQKTFRTEPPRELAALS 238 Query: 255 SNKQYKFQIDDELRVGINFE--------------------ALIMGHDDWISSLQWHESRL 294 N ++ + + + + GH I+S+ +H Sbjct: 239 PNYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGK 298 Query: 295 QLLAATADTSLMVWEPDETSGIWVCSLR 322 + D + + D + R Sbjct: 299 SYSSGGEDGYVRIHYFDPQYFEFEFEAR 326 Score = 66.1 bits (159), Expect = 6e-11, Method: Composition-based stats. Identities = 38/301 (12%), Positives = 78/301 (25%), Gaps = 60/301 (19%) Query: 181 SFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDL 240 I++ + GH V + + +GS D RLW Sbjct: 31 DPIVNVWYSVNGERLGTYMGHTGAVWCVDADW----DTKHVLTGSADNSCRLWDCETGKQ 86 Query: 241 -----------IDDSEEDSKKLTLLSNKQY---KFQIDDELRVGI-----NFEALIMGHD 281 + + ++KQ F +LR I +D Sbjct: 87 LALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCND 146 Query: 282 DWISSLQWHESRLQLLAATADTSLMVWEPDETS--------GIWVCSLRLGEMSSKGAST 333 I+S W ++A L + + ++L + + Sbjct: 147 SKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSREMTMFVTA 206 Query: 334 ATGSSGGFWSCLWFTH----------------ERMDFFLTNGKTGSWRMWATKDNI---- 373 + ++ + H + + G + + T I Sbjct: 207 SKDNTAKLFDSTTLEHQKTFRTEPPRELAALSPNYEHVVVGGGQEAMDVTTTSTRIGKFE 266 Query: 374 ------ICDQRLG-ISGATKDVTDIAWSPSGEYLLATSLDQTTRL--FAPWIYDASGRKR 424 ++ G + G + +A+ P G+ + D R+ F P ++ R Sbjct: 267 ARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRIHYFDPQYFEFEFEAR 326 Query: 425 E 425 E Sbjct: 327 E 327 Score = 48.0 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 41/239 (17%), Positives = 81/239 (33%), Gaps = 37/239 (15%) Query: 544 RHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALP 603 R +L L GH IT + + + L+ + + ++ ++ + N E Sbjct: 2 RPIL------LQGHERSITQIKYNREGDLLFTVAKDP-----IVNVWYSVNG-ERLGTYM 49 Query: 604 FHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAP 663 H+ + + D K +L+ D LW+ L+ T Sbjct: 50 GHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLK-------TNSAVRTCGFD 102 Query: 664 LEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIRE------- 716 + + + + + + D + I + + I +DS I Sbjct: 103 FGGNIIMFSTDKQMGYQCFVSFFDLRD----PSQIDNNEPYMKIPCNDSKITSAVWGPLG 158 Query: 717 KILISVGLENGEIYLYSYTLGKF-----ELITQLNEDITPADKITRLRWSHLKRNGKLF 770 + +I+ E+GE+ YS G+ E Q+N DI + ++T + KLF Sbjct: 159 ECIIAG-HESGELNQYSAKSGEVLVNVKEHSRQIN-DIQLSREMTMFVTASKDNTAKLF 215 Score = 39.9 bits (91), Expect = 0.005, Method: Composition-based stats. Identities = 61/365 (16%), Positives = 99/365 (27%), Gaps = 118/365 (32%) Query: 276 LIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTAT 335 L+ GH+ I+ ++++ L D + VW V RLG T Sbjct: 5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVW-------YSVNGERLG--------TYM 49 Query: 336 GSSGGFWSC-LWFTHERMDFFLTNGKTGSWRMWATKDNI------------ICDQRLG-- 380 G +G W + LT S R+W + C G Sbjct: 50 GHTGAVWCVDADWD---TKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGN 106 Query: 381 -----------------------------------ISGATKDVTDIAWSPSGEYLL---- 401 I +T W P GE ++ Sbjct: 107 IIMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHE 166 Query: 402 ATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKI 461 + L+Q + + + R+I + SR T FV+ + Sbjct: 167 SGELNQYSAKSGEVLVNVKEHSRQINDI-QLSR--------------EMTMFVTASKDNT 211 Query: 462 LRSFDLPKGVAGMLQKFVGIQFEEKSEM----PDSATVPVLGLSNKAGEDDANEDDEEEE 517 + FD L+ + E E+ P+ V V Sbjct: 212 AKLFDSTT-----LEHQKTFRTEPPRELAALSPNYEHVVV-------------------- 246 Query: 518 GGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASAC 577 GG +E D+T + + E + E ++ GH I + PD K +S Sbjct: 247 GGGQEAMDVTTTSTRIG--KFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGG 304 Query: 578 RSNNV 582 V Sbjct: 305 EDGYV 309 >4GGA-A nrPDB Length = 420 Score = 91.1 bits (224), Expect = 2e-18, Method: Composition-based stats. Identities = 62/369 (16%), Positives = 114/369 (30%), Gaps = 76/369 (20%) Query: 65 VRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTI-QHYSKTIVALSALPSLISVGCAD 123 V + + V+ D+ V +W + LQ +Q + VA + ++VG + Sbjct: 111 VDWSSGNVLAVA--LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 168 Query: 124 GTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFI 183 + +W Q + LS Y+L+ G + ++ Sbjct: 169 AEVQLWDVQQQKRL------RNMTSHSARVGSLSW-----NSYILSSGSRSGHIHHHDVR 217 Query: 184 LSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDD 243 +++ VA L GH V L + P L SG D + +W + Sbjct: 218 VAEHH------VATLSGHSQEVCGLRWA----PDGRHLASGGNDNLVNVWPSAPGE---- 263 Query: 244 SEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLA---AT 300 L+ H + ++ W + +LA T Sbjct: 264 ------------------GGWVPLQTFTQ-------HQGAVKAVAWCPWQSNVLATGGGT 298 Query: 301 ADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGK 360 +D + +W + + A + S LW H + Sbjct: 299 SDRHIRIWNVCSGACLS----------------AVDAHSQVCSILWSPHYKELISGHGFA 342 Query: 361 TGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYD-A 419 +W + + G T V + SP G + + + D+T RL+ + D A Sbjct: 343 QNQLVIWKYPTMAKVAE---LKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPA 399 Query: 420 SGRKREIAT 428 R+RE A+ Sbjct: 400 RRREREKAS 408 Score = 91.1 bits (224), Expect = 2e-18, Method: Composition-based stats. Identities = 46/300 (15%), Positives = 105/300 (35%), Gaps = 34/300 (11%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVK 84 ++A ++ LW + + ++ ++ V ++ + +++ + V+ Sbjct: 114 SSGNVLAVALDNSVYLWSASSGDILQLLQ-MEQPGEYISSVAWIKEGNYLAVGTSSAEVQ 172 Query: 85 IWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEF 144 +W D + ++ + +S + +LS ++S G G I + E Sbjct: 173 LW---DVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHI--------HHHDVRVAEH 221 Query: 145 TIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDW 204 + + + + LA GG + V + S G + H+ Sbjct: 222 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWP---SAPGEGGWVPLQTFTQHQGA 278 Query: 205 VKSLAFRHQETPGDYLLCSGS--QDRYIRLWRI----------RINDLIDDSEEDSKKLT 252 VK++A+ ++ +L +G DR+IR+W + + + K Sbjct: 279 VKAVAWCPWQSN---VLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKEL 335 Query: 253 LLSNK--QYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEP 310 + + Q + I + E + GH + SL + +A AD +L +W Sbjct: 336 ISGHGFAQNQLVIWKYPTMAKVAE--LKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 393 Score = 61.5 bits (147), Expect = 2e-09, Method: Composition-based stats. Identities = 27/194 (13%), Positives = 59/194 (30%), Gaps = 22/194 (11%) Query: 9 AIFIGAN-KQTQVSDIHKVKKIVAFGAGKTIALW-DPIEPNNKGVYATLKGHEAEVTCVR 66 A G + + + + + + G + +W T H+ V V Sbjct: 224 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 283 Query: 67 FVP-DSDFMVSAS--EDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSL--ISVGC 121 + P S+ + + D H++IW + C+ + +S+ ++ P + G Sbjct: 284 WCPWQSNVLATGGGTSDRHIRIWNVCSGA---CLSAVDAHSQVC-SILWSPHYKELISGH 339 Query: 122 A--DGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFI 179 + IW+ E LSL+ + +A + + + Sbjct: 340 GFAQNQLVIWK----YPTMAKVAELKGHTSRV----LSLTMSPDGA-TVASAAADETLRL 390 Query: 180 ASFILSDSGIEKCR 193 D + R Sbjct: 391 WRCFELDPARRRER 404 Score = 57.2 bits (136), Expect = 3e-08, Method: Composition-based stats. Identities = 41/313 (13%), Positives = 95/313 (30%), Gaps = 46/313 (14%) Query: 173 TNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIR- 231 + + L+ +E+ +++ L G + GS + R Sbjct: 30 KKEHQKAWALNLNGFDVEEAKIL-RLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRY 88 Query: 232 -------------LWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIM 278 + +L+D S + + L + I + Sbjct: 89 IPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVAL----DNSVYLWSASSGDILQLLQME 144 Query: 279 GHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSS 338 ++ISS+ W + L T+ + +W+ K T S Sbjct: 145 QPGEYISSVAWIKEGNYLAVGTSSAEVQLWDV---------------QQQKRLRNMTSHS 189 Query: 339 GGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGE 398 S W ++ + ++G + + +SG +++V + W+P G Sbjct: 190 ARVGSLSWNSY----ILSSGSRSGHIHHHDVR--VAEHHVATLSGHSQEVCGLRWAPDGR 243 Query: 399 YLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGG- 457 +L + D ++ A G + F++ Q + ++ GG Sbjct: 244 HLASGGNDNLVNVWP----SAPGEGGWVP-LQTFTQHQGAVKAVAWCPWQSNVLATGGGT 298 Query: 458 DEKILRSFDLPKG 470 ++ +R +++ G Sbjct: 299 SDRHIRIWNVCSG 311 Score = 52.2 bits (123), Expect = 9e-07, Method: Composition-based stats. Identities = 28/186 (15%), Positives = 69/186 (37%), Gaps = 18/186 (9%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 + + H + L + +++S RS ++ + +R+ L HS + Sbjct: 182 LRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRV-----AEHHVATLSGHSQEVC 234 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVF 670 L+++ DG+ L S D +W + + + + H + W P + NV Sbjct: 235 GLRWAPDGRHLASGGNDNLVNVWPSAPGEGGW-VPLQTFTQHQGAVKAVAWCPWQS-NVL 292 Query: 671 VT--ASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGE 728 T + D+ +++W +++ V +I ++++ G + Sbjct: 293 ATGGGTSDRHIRIWNVCSGA-----CLSAVDAHSQVCSILWSPHY--KELISGHGFAQNQ 345 Query: 729 IYLYSY 734 + ++ Y Sbjct: 346 LVIWKY 351 Score = 51.4 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 58/361 (16%), Positives = 114/361 (31%), Gaps = 78/361 (21%) Query: 280 HDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSG 339 +D +++ + W +LA D S+ +W + + + G Sbjct: 104 NDYYLNLVDWSSGN--VLAVALDNSVYLWSASSGDILQLLQMEQP--------------G 147 Query: 340 GFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEY 399 + S + + E ++ + ++W + ++ + V ++W Y Sbjct: 148 EYISSVAWIKEG-NYLAVGTSSAEVQLWDVQQQKRLR---NMTSHSARVGSLSW---NSY 200 Query: 400 LLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTR-FVSGGD 458 +L++ +R +D + +AT H ++ + D R SGG+ Sbjct: 201 ILSSG----SRSGHIHHHDVRVAEHHVATL------SGHSQEVCGLRWAPDGRHLASGGN 250 Query: 459 EKILRSFDLPKGVAGM--LQKFVGIQFEEKSEM--PDSATVPVLGLSNKAGEDDANEDDE 514 + ++ + G G LQ F Q K+ P + V L+ G D + Sbjct: 251 DNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV----LATGGGTSDRH---- 302 Query: 515 EEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKL-YGHGFEITCLDISPDQKLI 573 ++ + L Q+ L P ++L GHGF Sbjct: 303 ------IRIWNVCS-GACLSAVDAHSQVCSILWSPHYKELISGHGF-------------- 341 Query: 574 ASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALW 633 QN ++ + L H+ + L S DG + S D LW Sbjct: 342 --------AQNQLVIWK--YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 391 Query: 634 E 634 Sbjct: 392 R 392 Score = 44.5 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 30/206 (14%), Positives = 69/206 (33%), Gaps = 20/206 (9%) Query: 581 NVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDN 640 + N+V ++ + + I+ + + K+G +L + LW+ + Sbjct: 122 ALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQK- 180 Query: 641 TFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKH 700 R +N H+ + W + + SR + + ++ + H Sbjct: 181 ----RLRNMTSHSARVGSLSW----NSYILSSGSRSGHIHHHDVR---VAEHHVATLSGH 229 Query: 701 TKAVTAISIHDSMIREKILISVGLENGEIYLYSY-TLGKFELITQLNEDITPADKITRLR 759 ++ V + + L S G +N S G + + + + Sbjct: 230 SQEVCGLRWAPDG---RHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 286 Query: 760 WSHLKRNGKLFLGVGSSDLSTRIYSL 785 W ++ L G G+SD RI+++ Sbjct: 287 W----QSNVLATGGGTSDRHIRIWNV 308 >5LCW-Q nrPDB Length = 374 Score = 90.7 bits (223), Expect = 2e-18, Method: Composition-based stats. Identities = 49/298 (16%), Positives = 112/298 (37%), Gaps = 30/298 (10%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVK 84 ++A ++ LW + + ++ ++ V ++ + +++ + V+ Sbjct: 68 SSGNVLAVALDNSVYLWSASSGDILQLLQ-MEQPGEYISSVAWIKEGNYLAVGTSSAEVQ 126 Query: 85 IWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEF 144 +W D + ++ + +S + +LS ++S G G I + E Sbjct: 127 LW---DVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHI--------HHHDVRVAEH 175 Query: 145 TIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDW 204 + + + + LA GG + V + S G + H+ Sbjct: 176 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWP---SAPGEGGWVPLQTFTQHQGA 232 Query: 205 VKSLAFRHQETPGDYLLCSGS--QDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQ 262 VK++A+ ++ +L +G DR+IR+W + + + S+ ++L + YK Sbjct: 233 VKAVAWCPWQSN---VLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKEL 289 Query: 263 ID------DELRV----GINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEP 310 I ++L + + A + GH + SL + +A AD +L +W Sbjct: 290 ISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 347 Score = 90.3 bits (222), Expect = 3e-18, Method: Composition-based stats. Identities = 62/369 (16%), Positives = 114/369 (30%), Gaps = 76/369 (20%) Query: 65 VRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTI-QHYSKTIVALSALPSLISVGCAD 123 V + + V+ D+ V +W + LQ +Q + VA + ++VG + Sbjct: 65 VDWSSGNVLAVA--LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 122 Query: 124 GTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFI 183 + +W Q + LS Y+L+ G + ++ Sbjct: 123 AEVQLWDVQQQKRL------RNMTSHSARVGSLSW-----NSYILSSGSRSGHIHHHDVR 171 Query: 184 LSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDD 243 +++ VA L GH V L + P L SG D + +W + Sbjct: 172 VAEHH------VATLSGHSQEVCGLRWA----PDGRHLASGGNDNLVNVWPSAPGE---- 217 Query: 244 SEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLA---AT 300 L+ H + ++ W + +LA T Sbjct: 218 ------------------GGWVPLQTFTQ-------HQGAVKAVAWCPWQSNVLATGGGT 252 Query: 301 ADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGK 360 +D + +W + + A + S LW H + Sbjct: 253 SDRHIRIWNVCSGACLS----------------AVDAHSQVCSILWSPHYKELISGHGFA 296 Query: 361 TGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYD-A 419 +W + + G T V + SP G + + + D+T RL+ + D A Sbjct: 297 QNQLVIWKYPTMAKVAE---LKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPA 353 Query: 420 SGRKREIAT 428 R+RE A+ Sbjct: 354 RRREREKAS 362 Score = 61.1 bits (146), Expect = 2e-09, Method: Composition-based stats. Identities = 27/194 (13%), Positives = 59/194 (30%), Gaps = 22/194 (11%) Query: 9 AIFIGAN-KQTQVSDIHKVKKIVAFGAGKTIALW-DPIEPNNKGVYATLKGHEAEVTCVR 66 A G + + + + + + G + +W T H+ V V Sbjct: 178 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVA 237 Query: 67 FVP-DSDFMVSAS--EDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSL--ISVGC 121 + P S+ + + D H++IW + C+ + +S+ ++ P + G Sbjct: 238 WCPWQSNVLATGGGTSDRHIRIWNVCSGA---CLSAVDAHSQVC-SILWSPHYKELISGH 293 Query: 122 A--DGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFI 179 + IW+ E LSL+ + +A + + + Sbjct: 294 GFAQNQLVIWK----YPTMAKVAELKGHTSRV----LSLTMSPDGA-TVASAAADETLRL 344 Query: 180 ASFILSDSGIEKCR 193 D + R Sbjct: 345 WRCFELDPARRRER 358 Score = 56.8 bits (135), Expect = 4e-08, Method: Composition-based stats. Identities = 34/240 (14%), Positives = 78/240 (32%), Gaps = 31/240 (12%) Query: 232 LWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHE 291 + +L+D S + + L + I + ++ISS+ W + Sbjct: 56 IRNDYYLNLVDWSSGNVLAVAL----DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIK 111 Query: 292 SRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHER 351 L T+ + +W+ K T S S W ++ Sbjct: 112 EGNYLAVGTSSAEVQLWDV---------------QQQKRLRNMTSHSARVGSLSWNSY-- 154 Query: 352 MDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRL 411 + ++G + + +SG +++V + W+P G +L + D + Sbjct: 155 --ILSSGSRSGHIHHHDVR--VAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNV 210 Query: 412 FAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGG-DEKILRSFDLPKG 470 + A G + F++ Q + ++ GG ++ +R +++ G Sbjct: 211 WP----SAPGEGGWVP-LQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSG 265 Score = 51.8 bits (122), Expect = 1e-06, Method: Composition-based stats. Identities = 28/186 (15%), Positives = 69/186 (37%), Gaps = 18/186 (9%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 + + H + L + +++S RS ++ + +R+ L HS + Sbjct: 136 LRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRV-----AEHHVATLSGHSQEVC 188 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVF 670 L+++ DG+ L S D +W + + + + H + W P + NV Sbjct: 189 GLRWAPDGRHLASGGNDNLVNVWPSAPGEGGW-VPLQTFTQHQGAVKAVAWCPWQS-NVL 246 Query: 671 VT--ASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGE 728 T + D+ +++W +++ V +I ++++ G + Sbjct: 247 ATGGGTSDRHIRIWNVCSGA-----CLSAVDAHSQVCSILWSPHY--KELISGHGFAQNQ 299 Query: 729 IYLYSY 734 + ++ Y Sbjct: 300 LVIWKY 305 Score = 50.7 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 58/361 (16%), Positives = 114/361 (31%), Gaps = 78/361 (21%) Query: 280 HDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSG 339 +D +++ + W +LA D S+ +W + + + G Sbjct: 58 NDYYLNLVDWSSGN--VLAVALDNSVYLWSASSGDILQLLQMEQP--------------G 101 Query: 340 GFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEY 399 + S + + E ++ + ++W + ++ + V ++W Y Sbjct: 102 EYISSVAWIKEG-NYLAVGTSSAEVQLWDVQQQKRLR---NMTSHSARVGSLSW---NSY 154 Query: 400 LLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTR-FVSGGD 458 +L++ +R +D + +AT H ++ + D R SGG+ Sbjct: 155 ILSSG----SRSGHIHHHDVRVAEHHVATL------SGHSQEVCGLRWAPDGRHLASGGN 204 Query: 459 EKILRSFDLPKGVAGM--LQKFVGIQFEEKSEM--PDSATVPVLGLSNKAGEDDANEDDE 514 + ++ + G G LQ F Q K+ P + V L+ G D + Sbjct: 205 DNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV----LATGGGTSDRH---- 256 Query: 515 EEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKL-YGHGFEITCLDISPDQKLI 573 ++ + L Q+ L P ++L GHGF Sbjct: 257 ------IRIWNVCS-GACLSAVDAHSQVCSILWSPHYKELISGHGF-------------- 295 Query: 574 ASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALW 633 QN ++ + L H+ + L S DG + S D LW Sbjct: 296 --------AQNQLVIWK--YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 345 Query: 634 E 634 Sbjct: 346 R 346 Score = 44.1 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 30/206 (14%), Positives = 69/206 (33%), Gaps = 20/206 (9%) Query: 581 NVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDN 640 + N+V ++ + + I+ + + K+G +L + LW+ + Sbjct: 76 ALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQK- 134 Query: 641 TFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKH 700 R +N H+ + W + + SR + + ++ + H Sbjct: 135 ----RLRNMTSHSARVGSLSW----NSYILSSGSRSGHIHHHDVR---VAEHHVATLSGH 183 Query: 701 TKAVTAISIHDSMIREKILISVGLENGEIYLYSY-TLGKFELITQLNEDITPADKITRLR 759 ++ V + + L S G +N S G + + + + Sbjct: 184 SQEVCGLRWAPDG---RHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 240 Query: 760 WSHLKRNGKLFLGVGSSDLSTRIYSL 785 W ++ L G G+SD RI+++ Sbjct: 241 W----QSNVLATGGGTSDRHIRIWNV 262 >5CXC-A nrPDB Length = 510 Score = 89.2 bits (219), Expect = 7e-18, Method: Composition-based stats. Identities = 52/337 (15%), Positives = 104/337 (30%), Gaps = 55/337 (16%) Query: 6 TPEAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPN----NKGVYATLKGHEAE 61 +P G + + ++ + G +T+ +W E + L GH Sbjct: 183 SPSGSHGGHTASIKAAKFLTSDRLASAGMDRTVRVWKYTESDHFTGELKPTLELYGHTGS 242 Query: 62 VTCVRFVPDSDFMVSASEDHHVKIWKFTD------------YSHLQCIQTIQH------- 102 V + S +++AS D + W + +H+ + Sbjct: 243 VDWLDVDGHSKHILTASADGAIGFWSASKASAPEPDASLLPGAHVSKRRKATSSVSTAQR 302 Query: 103 --------YSKTIVALSALP---SLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFF 151 ++ A P ++ D T+ ++ + T Sbjct: 303 GPLGLWSIHTAPATAAIFDPRDRTVAYSASQDHTVR--TLDLTTGQVVSTLTLTHPLLSL 360 Query: 152 YPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFR 211 L + + LLA G + ++ + S + V L GH + V SL+ Sbjct: 361 SALTRAGTTSP----LLAAGTSARHITMVDPRASSATTS----VMTLRGHANKVVSLSPS 412 Query: 212 HQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGI 271 + +Y L SGS D R+W +R E +L + + I+ E Sbjct: 413 PE---NEYSLVSGSHDGTCRVWDLRSVRPATKEEG-----SLGGVSEPVYVIERESWASK 464 Query: 272 NFEALIMGHDD-WISSLQWHESRLQLLAATADTSLMV 307 + + D + S+ W + + + D + V Sbjct: 465 GKKKRPVAGDGCKVFSVVWDKLG--IFSGGEDKKVQV 499 Score = 82.3 bits (201), Expect = 9e-16, Method: Composition-based stats. Identities = 46/341 (13%), Positives = 97/341 (28%), Gaps = 66/341 (19%) Query: 58 HEAEVTCVRF----VPDSDF----------------MVSASEDHHVKIWKFTDYSHLQCI 97 H+ V+ V P + ++SAS D ++IW + Sbjct: 125 HDDWVSAVDVLSATSPAGRWSSAANSSAAVQPGQERVLSASYDGLLRIWNASGSVIATSP 184 Query: 98 QT-IQHYSKTIVALSA-LPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLC 155 ++ +I A ++ D T+ +W+ ++D F + T+ + + + Sbjct: 185 SGSHGGHTASIKAAKFLTSDRLASAGMDRTVRVWKY-TESDHFTGELKPTL-ELYGHTGS 242 Query: 156 LSLSKVEEKKYLLAIGGTNVNVFIAS----------------FILSDSGIEKCRVVAELE 199 + V+ + + + S +S V Sbjct: 243 VDWLDVDGHSKHILTASADGAIGFWSASKASAPEPDASLLPGAHVSKRRKATSSVSTAQR 302 Query: 200 G-------HEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLT 252 G H + F ++ Y S SQD +R + ++ L+ Sbjct: 303 GPLGLWSIHTAPATAAIFDPRDRTVAY---SASQDHTVRTLDLTTGQVVSTLTLTHPLLS 359 Query: 253 LLS---------------NKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQ-L 296 L + + ++ +D + GH + + SL L Sbjct: 360 LSALTRAGTTSPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSL 419 Query: 297 LAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGS 337 ++ + D + VW+ LG +S S Sbjct: 420 VSGSHDGTCRVWDLRSVRPATKEEGSLGGVSEPVYVIERES 460 Score = 77.2 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 45/305 (14%), Positives = 83/305 (27%), Gaps = 29/305 (9%) Query: 110 LSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLA 169 + + DG + IW + + S LA Sbjct: 154 VQPGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSD------RLA 207 Query: 170 IGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRY 229 G + V + + SD + + EL GH V L + + S D Sbjct: 208 SAGMDRTVRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGH----SKHILTASADGA 263 Query: 230 IRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQW 289 I W E D+ L + + L H ++ + Sbjct: 264 IGFWS---ASKASAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIF 320 Query: 290 HE-SRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFT 348 R +A+ D ++ + + +L +S + A +S Sbjct: 321 DPRDRTVAYSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTS---------- 370 Query: 349 HERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEY-LLATSLDQ 407 M + + + + G V ++ SP EY L++ S D Sbjct: 371 ----PLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDG 426 Query: 408 TTRLF 412 T R++ Sbjct: 427 TCRVW 431 Score = 42.2 bits (97), Expect = 0.001, Method: Composition-based stats. Identities = 24/148 (16%), Positives = 50/148 (33%), Gaps = 16/148 (10%) Query: 621 LLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVK 680 +LS D +W + HT I A + +A D+TV+ Sbjct: 161 VLSASYDGLLRIWNA-SGSVIATSPSGSHGGHTASIKA---AKFLTSDRLASAGMDRTVR 216 Query: 681 VWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKFE 740 VW++ + L+ +++ ++ D K +++ + G I +S + Sbjct: 217 VWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASAD-GAIGFWSASKAS-- 273 Query: 741 LITQLNEDITPADKITRLRWSHLKRNGK 768 P + L +H+ + K Sbjct: 274 ---------APEPDASLLPGAHVSKRRK 292 Score = 33.7 bits (75), Expect = 0.34, Method: Composition-based stats. Identities = 20/71 (28%), Positives = 31/71 (43%), Gaps = 8/71 (11%) Query: 395 PSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFV 454 P E +L+ S D R I++ASG IAT S H + + +T R Sbjct: 156 PGQERVLSASYDGLLR-----IWNASG--SVIATSPSGSHGG-HTASIKAAKFLTSDRLA 207 Query: 455 SGGDEKILRSF 465 S G ++ +R + Sbjct: 208 SAGMDRTVRVW 218 Score = 31.0 bits (68), Expect = 1.9, Method: Composition-based stats. Identities = 15/100 (15%), Positives = 28/100 (28%), Gaps = 18/100 (18%) Query: 666 FGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLE 725 ++AS D +++W + HT ++ A S Sbjct: 157 GQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSD------------ 204 Query: 726 NGEIYLYSYTLGKFELITQLNED--ITPADKITRLRWSHL 763 L S + + + + E T K T + H Sbjct: 205 ----RLASAGMDRTVRVWKYTESDHFTGELKPTLELYGHT 240 >4N14-A nrPDB Length = 314 Score = 88.8 bits (218), Expect = 8e-18, Method: Composition-based stats. Identities = 49/298 (16%), Positives = 112/298 (37%), Gaps = 30/298 (10%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVK 84 ++A ++ LW + + ++ ++ V ++ + +++ + V+ Sbjct: 30 SSGNVLAVALDNSVYLWSASSGDILQLLQ-MEQPGEYISSVAWIKEGNYLAVGTSSAEVQ 88 Query: 85 IWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEF 144 +W D + ++ + +S + +LS ++S G G I + E Sbjct: 89 LW---DVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHI--------HHHDVRVAEH 137 Query: 145 TIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDW 204 + + + + LA GG + V + S G + H+ Sbjct: 138 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWP---SAPGEGGWVPLQTFTQHQGA 194 Query: 205 VKSLAFRHQETPGDYLLCSGS--QDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQ 262 VK++A+ ++ +L +G DR+IR+W + + + S+ ++L + YK Sbjct: 195 VKAVAWCPWQSN---VLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKEL 251 Query: 263 ID------DELRV----GINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEP 310 I ++L + + A + GH + SL + +A AD +L +W Sbjct: 252 ISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 309 Score = 87.3 bits (214), Expect = 2e-17, Method: Composition-based stats. Identities = 56/352 (15%), Positives = 105/352 (29%), Gaps = 75/352 (21%) Query: 65 VRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTI-QHYSKTIVALSALPSLISVGCAD 123 V + + V+ D+ V +W + LQ +Q + VA + ++VG + Sbjct: 27 VDWSSGNVLAVA--LDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSS 84 Query: 124 GTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFI 183 + +W Q + LS Y+L+ G + ++ Sbjct: 85 AEVQLWDVQQQKRL------RNMTSHSARVGSLSW-----NSYILSSGSRSGHIHHHDVR 133 Query: 184 LSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDD 243 +++ VA L GH V L + P L SG D + +W + Sbjct: 134 VAEHH------VATLSGHSQEVCGLRWA----PDGRHLASGGNDNLVNVWPSAPGE---- 179 Query: 244 SEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLA---AT 300 L+ H + ++ W + +LA T Sbjct: 180 ------------------GGWVPLQTFTQ-------HQGAVKAVAWCPWQSNVLATGGGT 214 Query: 301 ADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGK 360 +D + +W + + A + S LW H + Sbjct: 215 SDRHIRIWNVCSGACLS----------------AVDAHSQVCSILWSPHYKELISGHGFA 258 Query: 361 TGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLF 412 +W + + G T V + SP G + + + D+T RL+ Sbjct: 259 QNQLVIWKYPTMAKVAE---LKGHTSRVLSLTMSPDGATVASAAADETLRLW 307 Score = 55.7 bits (132), Expect = 9e-08, Method: Composition-based stats. Identities = 34/240 (14%), Positives = 78/240 (32%), Gaps = 31/240 (12%) Query: 232 LWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHE 291 + +L+D S + + L + I + ++ISS+ W + Sbjct: 18 IRNDYYLNLVDWSSGNVLAVAL----DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIK 73 Query: 292 SRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHER 351 L T+ + +W+ K T S S W ++ Sbjct: 74 EGNYLAVGTSSAEVQLWDV---------------QQQKRLRNMTSHSARVGSLSWNSY-- 116 Query: 352 MDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRL 411 + ++G + + +SG +++V + W+P G +L + D + Sbjct: 117 --ILSSGSRSGHIHHHDVR--VAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNV 172 Query: 412 FAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGG-DEKILRSFDLPKG 470 + A G + F++ Q + ++ GG ++ +R +++ G Sbjct: 173 WP----SAPGEGGWVP-LQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSG 227 Score = 50.7 bits (119), Expect = 3e-06, Method: Composition-based stats. Identities = 28/186 (15%), Positives = 69/186 (37%), Gaps = 18/186 (9%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 + + H + L + +++S RS ++ + +R+ L HS + Sbjct: 98 LRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRV-----AEHHVATLSGHSQEVC 150 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVF 670 L+++ DG+ L S D +W + + + + H + W P + NV Sbjct: 151 GLRWAPDGRHLASGGNDNLVNVWPSAPGEGGW-VPLQTFTQHQGAVKAVAWCPWQS-NVL 208 Query: 671 VT--ASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGE 728 T + D+ +++W +++ V +I ++++ G + Sbjct: 209 ATGGGTSDRHIRIWNVCSGA-----CLSAVDAHSQVCSILWSPHY--KELISGHGFAQNQ 261 Query: 729 IYLYSY 734 + ++ Y Sbjct: 262 LVIWKY 267 Score = 48.7 bits (114), Expect = 9e-06, Method: Composition-based stats. Identities = 58/361 (16%), Positives = 114/361 (31%), Gaps = 78/361 (21%) Query: 280 HDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSG 339 +D +++ + W +LA D S+ +W + + + G Sbjct: 20 NDYYLNLVDWSSGN--VLAVALDNSVYLWSASSGDILQLLQMEQP--------------G 63 Query: 340 GFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEY 399 + S + + E ++ + ++W + ++ + V ++W Y Sbjct: 64 EYISSVAWIKEG-NYLAVGTSSAEVQLWDVQQQKRLR---NMTSHSARVGSLSW---NSY 116 Query: 400 LLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTR-FVSGGD 458 +L++ +R +D + +AT H ++ + D R SGG+ Sbjct: 117 ILSSG----SRSGHIHHHDVRVAEHHVATL------SGHSQEVCGLRWAPDGRHLASGGN 166 Query: 459 EKILRSFDLPKGVAGM--LQKFVGIQFEEKSEM--PDSATVPVLGLSNKAGEDDANEDDE 514 + ++ + G G LQ F Q K+ P + V L+ G D + Sbjct: 167 DNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNV----LATGGGTSDRH---- 218 Query: 515 EEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKL-YGHGFEITCLDISPDQKLI 573 ++ + L Q+ L P ++L GHGF Sbjct: 219 ------IRIWNVCS-GACLSAVDAHSQVCSILWSPHYKELISGHGF-------------- 257 Query: 574 ASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALW 633 QN ++ + L H+ + L S DG + S D LW Sbjct: 258 --------AQNQLVIWK--YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 307 Query: 634 E 634 Sbjct: 308 R 308 Score = 43.3 bits (100), Expect = 5e-04, Method: Composition-based stats. Identities = 30/206 (14%), Positives = 69/206 (33%), Gaps = 20/206 (9%) Query: 581 NVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDN 640 + N+V ++ + + I+ + + K+G +L + LW+ + Sbjct: 38 ALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQK- 96 Query: 641 TFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKH 700 R +N H+ + W + + SR + + ++ + H Sbjct: 97 ----RLRNMTSHSARVGSLSW----NSYILSSGSRSGHIHHHDVR---VAEHHVATLSGH 145 Query: 701 TKAVTAISIHDSMIREKILISVGLENGEIYLYSY-TLGKFELITQLNEDITPADKITRLR 759 ++ V + + L S G +N S G + + + + Sbjct: 146 SQEVCGLRWAPDG---RHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCP 202 Query: 760 WSHLKRNGKLFLGVGSSDLSTRIYSL 785 W ++ L G G+SD RI+++ Sbjct: 203 W----QSNVLATGGGTSDRHIRIWNV 224 >5WLC-LJ nrPDB Length = 513 Score = 85.3 bits (209), Expect = 8e-17, Method: Composition-based stats. Identities = 46/289 (15%), Positives = 94/289 (32%), Gaps = 35/289 (12%) Query: 3 ECITPEAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEV 62 + I + F + S K + A A ++++D P + H V Sbjct: 72 QVIKTFSRF--KDVVYSASFRSDGKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHV 129 Query: 63 TCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQ-CIQTIQHYSKTIVALSALPSLISVGC 121 T D+ + +AS+D ++W ++ Q + Y +T+ + A P L++ G Sbjct: 130 TKFH-TQDNKILATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGS 188 Query: 122 ADGTISIWRQNIQNDE--FGLAHEFTIKKGFFYPLCLSLS---------KVEEKKYLLAI 170 DG I ++ + L H+ ++ +S + K L Sbjct: 189 YDGLIRLYDTRSSGSTPIYSLNHDQPVENVIAVSPTQIVSCGGNNFKVWDLTSNKKLYER 248 Query: 171 GGTNVNVFIASFILS-DSGIEKCRVVAELEGH------------------EDWVKSLAFR 211 G N V ++ + DS ++ + + L+GH V S A Sbjct: 249 GNFNKAVTCLDYVENFDSPMQSALIASSLDGHVKVFDPLDNFQVKFGWKFSGPVLSCAVS 308 Query: 212 HQETPGDYLLCSGSQDRYIRLW-RIRINDLIDDSEEDSKKLTLLSNKQY 259 G+ L +G + + + + D + + + Sbjct: 309 PSTAQGNRHLVAGLSSGLLAIRTKKKEKRSSDKENAPASFNKNAKSNNF 357 Score = 44.5 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 43/227 (18%), Positives = 69/227 (30%), Gaps = 27/227 (11%) Query: 526 ITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDI---SPDQKLIASACRSNNV 582 IT LL P QR+ +L +T + P + S+ R Sbjct: 9 ITSKAPLL--PQQTTPEQRYWRQYTSAQLVKEHNSVTHISFNPQHPHDFAVTSSTR---- 62 Query: 583 QNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWER-NMEDNT 641 ++IFS+ IK F + F DGK L + ++++ N Sbjct: 63 ----VQIFSSRTRQVIKTFSRF-KDVVYSASFRSDGKLLCAGDATGLVSVYDSYNPRTIL 117 Query: 642 FELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHT 701 + H D + TAS D+ ++W L T Sbjct: 118 LSINASTHPTHVTKFHTQD------NKILATASDDRVTRLWDISNAYEPQLELT---GAT 168 Query: 702 KAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKFELITQLNED 748 V +S + ++ + + G I LY I LN D Sbjct: 169 DYVRTLSFIPA--APHLVATGSYD-GLIRLYDTRSSGSTPIYSLNHD 212 Score = 32.6 bits (72), Expect = 0.77, Method: Composition-based stats. Identities = 13/128 (10%), Positives = 41/128 (32%), Gaps = 12/128 (9%) Query: 349 HERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQT 408 + + + ++++++ + S V ++ G+ L A Sbjct: 48 NPQHPHDFAVTSSTRVQIFSSRTRQVIK---TFSRFKDVVYSASFRSDGKLLCAGDATGL 104 Query: 409 TRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLP 468 +YD+ + + + + H + T + + D+++ R +D+ Sbjct: 105 VS-----VYDSYNPRTILLSIN----ASTHPTHVTKFHTQDNKILATASDDRVTRLWDIS 155 Query: 469 KGVAGMLQ 476 L+ Sbjct: 156 NAYEPQLE 163 >4U1E-I nrPDB Length = 347 Score = 85.3 bits (209), Expect = 9e-17, Method: Composition-based stats. Identities = 58/361 (16%), Positives = 115/361 (31%), Gaps = 49/361 (13%) Query: 54 TLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSAL 113 L GHE +T V++ + D + S S+D +W + + + T+ ++ TI ++ Sbjct: 5 KLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNG---ERLGTLDGHTGTIWSIDVD 61 Query: 114 --PSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIG 171 G AD +I +W + +K+ F P + + + G Sbjct: 62 CFTKYCVTGSADYSIKLWDVSNGQCVATWKSPVPVKRVEFSPCGNYFLAILDN-VMKNPG 120 Query: 172 GTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIR 231 N+ + + ++ HE A + + +G +D I Sbjct: 121 SINIYEIERDSATHELTKVSEEPIHKIITHEG--LDAATVAGWSTKGKYIIAGHKDGKIS 178 Query: 232 LWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHE 291 + + N +Y ID H+ IS +Q+ Sbjct: 179 KYDVSN------------------NYEYVDSIDL--------------HEKSISDMQFSP 206 Query: 292 SRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHER 351 + ++ DT+ + + + V + A + L E Sbjct: 207 DLTYFITSSRDTNSFLVDVST---LQVLKKYETDCPLNTAVITPLKE---FIILGGGQEA 260 Query: 352 MDFFLTNGKTGSWRMWATKDNIICDQRLG-ISGATKDVTDIAWSPSGEYLLATSLDQTTR 410 D T+ G + A + I ++ +G + G + +A SP G + D R Sbjct: 261 KDVTTTSANEG--KFEARFYHKIFEEEIGRVQGHFGPLNTVAISPQGTSYASGGEDGFIR 318 Query: 411 L 411 L Sbjct: 319 L 319 Score = 85.0 bits (208), Expect = 1e-16, Method: Composition-based stats. Identities = 50/356 (14%), Positives = 108/356 (30%), Gaps = 59/356 (16%) Query: 16 KQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMV 75 TQV + + + + ++W + TL GH + + + + V Sbjct: 12 PLTQVKYNKEGDLLFSCSKDSSASVWYSLNGER---LGTLDGHTGTIWSIDVDCFTKYCV 68 Query: 76 SASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISV-GCAD------GTISI 128 + S D+ +K+W ++ QC+ T + + + P D G+I+I Sbjct: 69 TGSADYSIKLWDVSNG---QCVATWKSPV-PVKRVEFSPCGNYFLAILDNVMKNPGSINI 124 Query: 129 WRQ--NIQNDEFGLAHEFTIKKGFFY---PLCLSLSKVEEKKYLLAIGGTNVNVFIASFI 183 + + E E I K + + KY++A G + + Sbjct: 125 YEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIA-GHKDGKISKYDV- 182 Query: 184 LSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDD 243 V ++ HE + + F T + S+D L + ++ Sbjct: 183 -----SNNYEYVDSIDLHEKSISDMQFSPDLT----YFITSSRDTNSFLVDVSTLQVLKK 233 Query: 244 SEED----------------------SKKLTLLSNKQYKFQIDDELRVGINFEALIMGHD 281 E D +K +T S + KF+ ++ + GH Sbjct: 234 YETDCPLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEEEIGRVQGHF 293 Query: 282 DWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGS 337 ++++ + D + + + S + + A+ A Sbjct: 294 GPLNTVAISPQGTSYASGGEDGFIRL-------HHFEKSYFDFKYDVEKAAEAKEH 342 Score = 48.7 bits (114), Expect = 1e-05, Method: Composition-based stats. Identities = 36/169 (21%), Positives = 62/169 (36%), Gaps = 21/169 (12%) Query: 602 LPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADW 661 L H +T++K++K+G L S +D ++W + L HT IW D Sbjct: 6 LTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTL-----DGHTGTIWSIDV 60 Query: 662 APLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILIS 721 F VT S D ++K+W + A+ K V + ++ Sbjct: 61 D--CFTKYCVTGSADYSIKLWDV-----SNGQCVATWKSPVPVKRVEFSPCGNYFLAILD 113 Query: 722 VGLEN-GEIYLYSYTLGKFEL-ITQLNEDI-------TPADKITRLRWS 761 ++N G I +Y +T+++E+ D T WS Sbjct: 114 NVMKNPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWS 162 Score = 43.3 bits (100), Expect = 4e-04, Method: Composition-based stats. Identities = 26/187 (13%), Positives = 65/187 (34%), Gaps = 14/187 (7%) Query: 553 KLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRL 612 KL GH +T + + + L+ S + ++ ++ + N E L H+ TI + Sbjct: 5 KLTGHERPLTQVKYNKEGDLLFSCSKDSSA-----SVWYSLNG-ERLGTLDGHTGTIWSI 58 Query: 613 KFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVT 672 K+ ++ D LW+ + + ++ NV Sbjct: 59 DVDCFTKYCVTGSADYSIKLWDVSNGQCVATWKSPVPVKRVEFSPCGNYFLAILDNVM-- 116 Query: 673 ASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLY 732 ++ ++ +++ A + + S + + I H+ + ++ G+ + Sbjct: 117 -KNPGSINIYEIERDSATHELTKVS---EEPIHKIITHEGLDAA--TVAGWSTKGKYIIA 170 Query: 733 SYTLGKF 739 + GK Sbjct: 171 GHKDGKI 177 Score = 33.7 bits (75), Expect = 0.28, Method: Composition-based stats. Identities = 12/68 (17%), Positives = 27/68 (39%), Gaps = 4/68 (5%) Query: 345 LWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATS 404 + + E D + K S +W ++ ++ + G T + I +Y + S Sbjct: 16 VKYNKEG-DLLFSCSKDSSASVW---YSLNGERLGTLDGHTGTIWSIDVDCFTKYCVTGS 71 Query: 405 LDQTTRLF 412 D + +L+ Sbjct: 72 ADYSIKLW 79 Score = 32.2 bits (71), Expect = 0.87, Method: Composition-based stats. Identities = 16/92 (17%), Positives = 38/92 (41%), Gaps = 11/92 (11%) Query: 379 LGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIH 438 + ++G + +T + ++ G+ L + S D + ++ Y +G + H Sbjct: 4 IKLTGHERPLTQVKYNKEGDLLFSCSKDSSASVW----YSLNGERLGTLDGHT------G 53 Query: 439 GYDMICVETVTDTRFVSGGDEKILRSFDLPKG 470 I V+ T V+G + ++ +D+ G Sbjct: 54 TIWSIDVDCFTK-YCVTGSADYSIKLWDVSNG 84 Score = 29.9 bits (65), Expect = 4.8, Method: Composition-based stats. Identities = 28/128 (21%), Positives = 57/128 (44%), Gaps = 15/128 (11%) Query: 614 FSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTA 673 +S GK++++ +D K + ++ + N +E + H + I D ++P F+T+ Sbjct: 161 WSTKGKYIIAGHKDGKISKYDVS---NNYEYVDSID-LHEKSISDMQFSP--DLTYFITS 214 Query: 674 SRDKTVKVWRHQK-EPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLY 732 SRD + + Y + + TA+ + ++E I++ G E ++ Sbjct: 215 SRDTNSFLVDVSTLQVLKKYETDCPLN-----TAVI---TPLKEFIILGGGQEAKDVTTT 266 Query: 733 SYTLGKFE 740 S GKFE Sbjct: 267 SANEGKFE 274 >6CHG-A nrPDB Length = 312 Score = 84.6 bits (207), Expect = 2e-16, Method: Composition-based stats. Identities = 43/234 (18%), Positives = 83/234 (35%), Gaps = 24/234 (10%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVK 84 K I + T+ + G L GH A V + + + + S+S D +K Sbjct: 65 DSKCIASGSEDFTVEI----THIIYGRIRRLMGHTAPVISICYNNKGNILCSSSMDESIK 120 Query: 85 IWKFTDYSHLQCIQTIQHYSKTIVALS---ALPSLISVGCADGTISIWRQNIQNDEFGLA 141 W ++T+ +S +V++ S++S G DG I I+ + L Sbjct: 121 EWHVLSG---TALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLT 177 Query: 142 HEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAE-LEG 200 ++ ++ K+LL NV V + + + VV L Sbjct: 178 YDKDWIAEDGVVPISTVKFSRNGKFLLVKSLDNV-VKLWEYT-------RGTVVRTFLWP 229 Query: 201 HEDWVKSLAFRH-----QETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSK 249 H++ L + D L+ SG+ + +W + +L+ +E + Sbjct: 230 HQETKAKLKYNCGLELIYPQGKDPLVISGNDSGSMCVWNVYSKNLVQKIDEKHR 283 Score = 76.9 bits (187), Expect = 3e-14, Method: Composition-based stats. Identities = 32/246 (13%), Positives = 78/246 (31%), Gaps = 28/246 (11%) Query: 13 GANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSD 72 + K + I +++A + +++ + T H+ + C+ + PDS Sbjct: 11 ASGKISTSCQISPDGELIAICQNTDMLVYEISSSKMMKLTTT---HKECINCLCWSPDSK 67 Query: 73 FMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTI--VALSALPSLISVGCADGTISIWR 130 + S SED V+I + I+ + ++ + + + +++ D +I W Sbjct: 68 CIASGSEDFTVEI----THIIYGRIRRLMGHTAPVISICYNNKGNILCSSSMDESIKEWH 123 Query: 131 QNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIE 190 + +S+ + +L+ G + + I E Sbjct: 124 VLSGTALKTM--------SAHSDAVVSIDIPKFDSSILSSGSYDGLIRI-------FDTE 168 Query: 191 KCRVVAELEGHEDWVKSLAFRHQE----TPGDYLLCSGSQDRYIRLWRIRINDLIDDSEE 246 + L +DW+ + L S D ++LW ++ Sbjct: 169 SGHCLKTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLW 228 Query: 247 DSKKLT 252 ++ Sbjct: 229 PHQETK 234 Score = 51.8 bits (122), Expect = 1e-06, Method: Composition-based stats. Identities = 40/219 (18%), Positives = 64/219 (29%), Gaps = 30/219 (13%) Query: 557 HGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSK 616 H I CL SPD K IAS V+ I L H+ + + ++ Sbjct: 53 HKECINCLCWSPDSKCIASGSEDFTVEITHIIYGRIRR-------LMGHTAPVISICYNN 105 Query: 617 DGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRD 676 G L S D W + ++ + I P ++ + S D Sbjct: 106 KGNILCSSSMDESIKEWHVLSGTALKTMSAHSDAVVSIDI------PKFDSSILSSGSYD 159 Query: 677 KTVKVWRHQ-KEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYT 735 ++++ + + V IS K L+ L+N + L+ YT Sbjct: 160 GLIRIFDTESGHCLKTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVKSLDN-VVKLWEYT 218 Query: 736 LGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVG 774 G W H + KL G Sbjct: 219 RGTVVRTF---------------LWPHQETKAKLKYNCG 242 Score = 51.8 bits (122), Expect = 1e-06, Method: Composition-based stats. Identities = 42/327 (12%), Positives = 97/327 (29%), Gaps = 89/327 (27%) Query: 156 LSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQET 215 S + + + T++ V+ I +++ H++ + L + Sbjct: 17 TSCQISPDGELIAICQNTDMLVY---------EISSSKMMKLTTTHKECINCLCWS---- 63 Query: 216 PGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEA 275 P + SGS+D + + I + Sbjct: 64 PDSKCIASGSEDFTVEITHIIYGRI----------------------------------R 89 Query: 276 LIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTAT 335 +MGH + S+ ++ L +++ D S+ W + + S Sbjct: 90 RLMGHTAPVISICYNNKGNILCSSSMDESIKEWHVLSGTALKTMS--------------- 134 Query: 336 GSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKD-NIICDQRLGISGATKD----VTD 390 + + + G R++ T+ + + +D ++ Sbjct: 135 -AHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWIAEDGVVPIST 193 Query: 391 IAWSPSGEYLLATSLDQTTRLFAP----------WIYDASGRKREIATWHEFSRPQIHGY 440 + +S +G++LL SLD +L+ W + + K + E PQ Sbjct: 194 VKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLKYNCGLELIYPQG--- 250 Query: 441 DMICVETVTDTRFVSGGDEKILRSFDL 467 D +SG D + +++ Sbjct: 251 --------KDPLVISGNDSGSMCVWNV 269 Score = 45.3 bits (105), Expect = 1e-04, Method: Composition-based stats. Identities = 17/128 (13%), Positives = 47/128 (36%), Gaps = 12/128 (9%) Query: 13 GANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFV---- 68 G + V K ++ + LW+ + L H+ +++ Sbjct: 187 GVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTF--LWPHQETKAKLKYNCGLE 244 Query: 69 ---PDS--DFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCAD 123 P ++S ++ + +W + +Q I +H + ++++SA ++ + Sbjct: 245 LIYPQGKDPLVISGNDSGSMCVWNVYSKNLVQKID-EKHRNSPLISISASYDKVATLSLN 303 Query: 124 GTISIWRQ 131 G +++R Sbjct: 304 GECNLFRV 311 Score = 43.0 bits (99), Expect = 5e-04, Method: Composition-based stats. Identities = 28/147 (19%), Positives = 57/147 (38%), Gaps = 14/147 (9%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLT-- 608 ++ + H + +DI I S+ + +IRIF TE+ +K Sbjct: 130 LKTMSAHSDAVVSIDIPKFDSSILSSGSY----DGLIRIFDTESGHCLKTLTYDKDWIAE 185 Query: 609 -----ITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWA- 662 I+ +KFS++GKFLL D LWE + +++ ++ ++ Sbjct: 186 DGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLKYNCGLEL 245 Query: 663 --PLEFGNVFVTASRDKTVKVWRHQKE 687 P + ++ + ++ VW + Sbjct: 246 IYPQGKDPLVISGNDSGSMCVWNVYSK 272 Score = 39.5 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 22/118 (18%), Positives = 38/118 (32%), Gaps = 31/118 (26%) Query: 384 ATKDVTDIAWSPSGEYLLATSLDQTTRL--------------FAPWI---YDASGR---- 422 + + + WSP + + + S D T + AP I Y+ G Sbjct: 53 HKECINCLCWSPDSKCIASGSEDFTVEITHIIYGRIRRLMGHTAPVISICYNNKGNILCS 112 Query: 423 ---KREIATWHEFS-----RPQIHGYDMICVE--TVTDTRFVSGGDEKILRSFDLPKG 470 I WH S H ++ ++ + SG + ++R FD G Sbjct: 113 SSMDESIKEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESG 170 >4AEZ-A nrPDB Length = 401 Score = 83.8 bits (205), Expect = 2e-16, Method: Composition-based stats. Identities = 49/302 (16%), Positives = 93/302 (30%), Gaps = 37/302 (12%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 +VA + + +W+ + + T + V V++ D F+ + V Sbjct: 106 VVAVALERNVYVWNADSGSVSALAETDE--STYVASVKWSHDGSFLSVGLGNGLV---DI 160 Query: 89 TDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKK 148 D ++T+ + + LS ++S G G I I N + G Sbjct: 161 YDVESQTKLRTMAGHQARVGCLSWNRHVLSSGSRSGAIHHHDVRIANHQIGTLQ------ 214 Query: 149 GFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSL 208 + + LA GG + V I S H VK++ Sbjct: 215 --GHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKF-------TKTNHNAAVKAV 265 Query: 209 AFRHQETPGDYLLCSGS--QDRYIRLWRIRINDLIDDSEEDSKKLTLLSN---------- 256 A+ ++ LL +G D+ I W ++ + S+ +L+ + Sbjct: 266 AWCPWQSN---LLATGGGTMDKQIHFWNAATGARVNTVDAGSQVTSLIWSPHSKEIMSTH 322 Query: 257 --KQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETS 314 I G+ + I HD + L A +D +L W + Sbjct: 323 GFPDNNLSIWSYSSSGLTKQVDIPAHDTRVLYSALSPDGRILSTAASDENLKFWRVYDGD 382 Query: 315 GI 316 + Sbjct: 383 HV 384 Score = 78.0 bits (190), Expect = 1e-14, Method: Composition-based stats. Identities = 41/243 (16%), Positives = 75/243 (30%), Gaps = 24/243 (9%) Query: 2 VECITPEAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAE 61 VE T G + + V ++ A+ TL+GH +E Sbjct: 163 VESQTKLRTMAGHQARVGCL---SWNRHVLSSGSRSGAIHHHDVRIANHQIGTLQGHSSE 219 Query: 62 VTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGC 121 V + + D + S D+ V+IW K + +L++ G Sbjct: 220 VCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATGG 279 Query: 122 A--DGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGT-NVNVF 178 D I W + SL K +++ G + N+ Sbjct: 280 GTMDKQIHFWNAATGAR---------VNTVDAGSQVTSLIWSPHSKEIMSTHGFPDNNLS 330 Query: 179 IASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRIN 238 I S+ S + ++ H+ V A P +L + + D ++ WR+ Sbjct: 331 IWSYSSSGLTKQ-----VDIPAHDTRVLYSALS----PDGRILSTAASDENLKFWRVYDG 381 Query: 239 DLI 241 D + Sbjct: 382 DHV 384 Score = 68.8 bits (166), Expect = 9e-12, Method: Composition-based stats. Identities = 48/353 (13%), Positives = 100/353 (28%), Gaps = 85/353 (24%) Query: 110 LSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLA 169 L + + + +W + + Y + S Sbjct: 99 LDWSNLNVVAVALERNVYVWNADSGSVSA-----LAETDESTYVASVKWSH--------- 144 Query: 170 IGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRY 229 G+ ++V + + ++ +E + + GH+ V L++ ++L SGS+ Sbjct: 145 -DGSFLSVGLGNGLVDIYDVESQTKLRTMAGHQARVGCLSWNR------HVLSSGSRSGA 197 Query: 230 IRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQW 289 I ++R+ + + GH + L W Sbjct: 198 IH--------------------------------HHDVRIANHQIGTLQGHSSEVCGLAW 225 Query: 290 HESRLQLLAATADTSLMVWEPDETSGIWVCSL----------------------RLGEMS 327 LQL + D + +W+ + + + + Sbjct: 226 RSDGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQ 285 Query: 328 SKGASTATGSS-------GGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLG 380 + ATG+ S +W H + + +W+ + + Q + Sbjct: 286 IHFWNAATGARVNTVDAGSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQ-VD 344 Query: 381 ISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFS 433 I V A SP G L + D+ + + +YD KR I S Sbjct: 345 IPAHDTRVLYSALSPDGRILSTAASDENLKFWR--VYDGDHVKRPIPITKTPS 395 Score = 64.5 bits (155), Expect = 2e-10, Method: Composition-based stats. Identities = 46/238 (19%), Positives = 93/238 (39%), Gaps = 29/238 (12%) Query: 550 EVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTI 609 ++ + GH + CL ++ +++S RS + + +RI + + L HS + Sbjct: 168 KLRTMAGHQARVGCLSW--NRHVLSSGSRSGAIHHHDVRIANHQIG-----TLQGHSSEV 220 Query: 610 TRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNV 669 L + DG L S D +W+ F + H + W P + N+ Sbjct: 221 CGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFT-----KTNHNAAVKAVAWCPWQS-NL 274 Query: 670 FVT--ASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENG 727 T + DK + W + V S VT++ ++I+ + G + Sbjct: 275 LATGGGTMDKQIHFWNAATGARVNTVDAGS-----QVTSLIWSPH--SKEIMSTHGFPDN 327 Query: 728 EIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYSL 785 + ++SY+ + PA TR+ +S L +G++ L +SD + + + + Sbjct: 328 NLSIWSYSSSGLTKQVDI-----PAHD-TRVLYSALSPDGRI-LSTAASDENLKFWRV 378 Score = 44.5 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 56/378 (14%), Positives = 116/378 (30%), Gaps = 71/378 (18%) Query: 281 DDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGG 340 D +++ L W L ++A + ++ VW D S ++ A Sbjct: 93 DYYLNLLDWS--NLNVVAVALERNVYVWNADSGS---------------VSALAETDEST 135 Query: 341 FWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYL 400 + + + ++H+ + G G ++ + ++G V ++W ++ Sbjct: 136 YVASVKWSHDGSFLSVGLG-NGLVDIYDVESQTKLR---TMAGHQARVGCLSW---NRHV 188 Query: 401 LATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEK 460 L++ +R A +D +I T S + SGG++ Sbjct: 189 LSSG----SRSGAIHHHDVRIANHQIGTLQGHSSEVCGLAWRS-----DGLQLASGGNDN 239 Query: 461 ILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGN 520 +++ +D + + + + P + + L+ G D G Sbjct: 240 VVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNL----LATGGGTMDKQIHFWNAATGA 295 Query: 521 KETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSN 580 + + D S + L+W H EI PD L Sbjct: 296 R--VNTVDAGSQVTS----------LIWSP------HSKEIMSTHGFPDNNL-------- 329 Query: 581 NVQNAVIRIFS-TENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMED 639 I+S + + L + +P H + S DG+ L + D W D Sbjct: 330 -------SIWSYSSSGLTKQVDIPAHDTRVLYSALSPDGRILSTAASDENLKFWRVYDGD 382 Query: 640 NTFELRFKNEKPHTRIIW 657 + + P + I Sbjct: 383 HVKRPIPITKTPSSSITI 400 Score = 43.0 bits (99), Expect = 5e-04, Method: Composition-based stats. Identities = 30/237 (12%), Positives = 66/237 (27%), Gaps = 49/237 (20%) Query: 584 NAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFE 643 + +++ ++ A S + +K+S DG FL + +++ + Sbjct: 112 ERNVYVWNADSGSVSALAETDESTYVASVKWSHDGSFLSVGLGNGLVDIYDVESQTKLRT 171 Query: 644 LRFKN------------------------------------EKPHTRIIWDADWAPLEFG 667 + + H+ + W G Sbjct: 172 MAGHQARVGCLSWNRHVLSSGSRSGAIHHHDVRIANHQIGTLQGHSSEVCGLAW--RSDG 229 Query: 668 NVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENG 727 + D V++W + H AV A++ + G + Sbjct: 230 LQLASGGNDNVVQIWDARSSIPK----FTKTNHNAAVKAVAWCPWQS-NLLATGGGTMDK 284 Query: 728 EIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYS 784 +I+ ++ G + ++T L WS + G ++LS YS Sbjct: 285 QIHFWNAATGARV------NTVDAGSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYS 335 Score = 38.3 bits (87), Expect = 0.013, Method: Composition-based stats. Identities = 11/61 (18%), Positives = 24/61 (39%), Gaps = 1/61 (1%) Query: 35 GKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHL 94 +++W + H+ V PD + +A+ D ++K W+ D H+ Sbjct: 326 DNNLSIWSYSSSGLTKQV-DIPAHDTRVLYSALSPDGRILSTAASDENLKFWRVYDGDHV 384 Query: 95 Q 95 + Sbjct: 385 K 385 >5OQL-X nrPDB Length = 630 Score = 83.4 bits (204), Expect = 3e-16, Method: Composition-based stats. Identities = 28/201 (13%), Positives = 61/201 (30%), Gaps = 49/201 (24%) Query: 601 ALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDAD 660 H +K S+DGKF+++ D++ ++ + Sbjct: 241 TYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLKPIKAFTQHRDAV-------TG 293 Query: 661 WAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILI 720 A N + S+D+TVKVW + +E H + I D++ +E+ + Sbjct: 294 LAFRRGTNQLYSCSKDRTVKVWSLDELA----YVETLFGHQDEILDI---DALGQERCVS 346 Query: 721 SVGLE----------NGEIYLYSYT-----------------------LGKFELITQLNE 747 + ++ G + + +++ Sbjct: 347 VGARDRTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAMIDD 406 Query: 748 D--ITPADKITRLRWSHLKRN 766 D +T +D WS ++ Sbjct: 407 DMFVTGSDNGDLALWSIQRKK 427 Score = 81.9 bits (200), Expect = 1e-15, Method: Composition-based stats. Identities = 50/255 (19%), Positives = 84/255 (32%), Gaps = 45/255 (17%) Query: 20 VSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASE 79 V K +V GA K + +++ + H VT + F ++ + S S+ Sbjct: 252 VKASQDGKFVVTGGADKRLVVYNA---ADLKPIKAFTQHRDAVTGLAFRRGTNQLYSCSK 308 Query: 80 DHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS--LISVGCADGTISIWRQNIQNDE 137 D VK+W L ++T+ + I+ + AL +SVG D T W+ ++ Sbjct: 309 DRTVKVWSLD---ELAYVETLFGHQDEILDIDALGQERCVSVGARDRTARYWKVPEESQL 365 Query: 138 FGLAHEFTIK----KGFFYPLCLSLSKVEEKKY---------LLAIGGTNVNVFIASFIL 184 K P S E + G N ++ + S Sbjct: 366 VFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAMIDDDMFVTGSDNGDLALWSI-- 423 Query: 185 SDSGIEKCRVVAELEGHEDWVKSLAFRHQETPG--------------------DYLLCSG 224 + V+A G E +K + E P L+ SG Sbjct: 424 --QRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQPRGITALRTLPYSDLIFSG 481 Query: 225 SQDRYIRLWRIRIND 239 S D IR+WR+ + Sbjct: 482 SWDGCIRVWRLSEDK 496 Score = 69.9 bits (169), Expect = 4e-12, Method: Composition-based stats. Identities = 44/296 (14%), Positives = 95/296 (32%), Gaps = 23/296 (7%) Query: 53 ATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSA 112 T +GH V+ D F+V+ D + ++ D L+ I+ + + L+ Sbjct: 240 KTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAAD---LKPIKAFTQHRDAVTGLAF 296 Query: 113 L--PSLISVGCADGTISIWRQN-IQNDEFGLAHEFTI--KKGFFYPLCLSLSKVEEKKYL 167 + + D T+ +W + + E H+ I C+S+ + Sbjct: 297 RRGTNQLYSCSKDRTVKVWSLDELAYVETLFGHQDEILDIDALGQERCVSVGARDRTARY 356 Query: 168 LAIGGTNVNVFIASFILSDSGIEKCRVVAELE----GHEDWVKSLAFRHQETPGDYLLCS 223 + + VF S +K ++ ++ HE + D + + Sbjct: 357 WKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEG-----SMDRVAMIDDDMFVT 411 Query: 224 GSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDW 283 GS + + LW I+ + + + Y + + + Sbjct: 412 GSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQPR------G 465 Query: 284 ISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSG 339 I++L+ + + + D + VW E LG S ++ S+G Sbjct: 466 ITALRTLPYSDLIFSGSWDGCIRVWRLSEDKRKLEAVGILGVGSETCENSTNISNG 521 Score = 66.8 bits (161), Expect = 3e-11, Method: Composition-based stats. Identities = 52/386 (13%), Positives = 106/386 (27%), Gaps = 80/386 (20%) Query: 48 NKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQ------------ 95 +K Y + + VT V P + + ++D ++ WK D Q Sbjct: 159 DKATYTQFRWNSGTVTSVAVCP--PYAYTTTKDGYLTKWKLQDLPKNQWPQTTKKKPKKP 216 Query: 96 -----------CI----------QTIQHYSKT--IVALSALPSLISVGCADGTISIWRQN 132 C +T Q + K +V S + G AD + ++ Sbjct: 217 PAPPKKRPERICFAKADARKANDKTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAA 276 Query: 133 IQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKC 192 FT + L + L + V + S Sbjct: 277 DLKP----IKAFTQHRDAVTGLAFRRGTNQ-----LYSCSKDRTVKVWSLDELAY----- 322 Query: 193 RVVAELEGHEDWVKSLAFRHQETPGDYLLCS-GSQDRYIRLWRIRINDLIDDSEEDSKKL 251 V L GH+D + + G S G++DR R W++ + +L Sbjct: 323 --VETLFGHQDEILDID-----ALGQERCVSVGARDRTARYWKV----------PEESQL 365 Query: 252 TLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPD 311 + + ++ + H+ + + + + + + + L +W Sbjct: 366 VFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAMIDDDMF-VTGSDNGDLALWSIQ 424 Query: 312 ETSGIWVCSLR---LGEMSSKGASTATGSSGGFW-------SCLWFTHERMDFFLTNGKT 361 + V + + + S T D + Sbjct: 425 RKKPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQPRGITALRTLPYSDLIFSGSWD 484 Query: 362 GSWRMWATKDNIICDQRLGISGATKD 387 G R+W ++ + +GI G + Sbjct: 485 GCIRVWRLSEDKRKLEAVGILGVGSE 510 Score = 60.3 bits (144), Expect = 3e-09, Method: Composition-based stats. Identities = 42/319 (13%), Positives = 93/319 (29%), Gaps = 53/319 (16%) Query: 202 EDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRI------NDLIDDSEEDSKKLTLLS 255 V S+A + ++D Y+ W+++ + Sbjct: 170 SGTVTSVAVCP------PYAYTTTKDGYLTKWKLQDLPKNQWPQTTKKKPKKPPAPPKKR 223 Query: 256 NKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSG 315 ++ F D + + GH ++ + ++ AD L+V+ Sbjct: 224 PERICFAKADARKAN---DKTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNA----- 275 Query: 316 IWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIIC 375 K T + + + K + ++W+ + Sbjct: 276 ----------ADLKPIKAFTQHRDAVTGLAF--RRGTNQLYSCSKDRTVKVWSLDELAYV 323 Query: 376 DQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLF-----APWIYDASGRKREIATWH 430 + + G ++ DI + + D+T R + + ++ G T Sbjct: 324 E---TLFGHQDEILDIDALGQERCVSVGARDRTARYWKVPEESQLVFRGGGEGGSSNTKK 380 Query: 431 EFSRPQ------IHGYDMICVETVTDTRFVSGGDEKILRSFDLPK-------GVAGMLQK 477 P H M V + D FV+G D L + + + A L+ Sbjct: 381 HKLPPGMDPASAAHEGSMDRVAMIDDDMFVTGSDNGDLALWSIQRKKPLHVIARAHGLEP 440 Query: 478 FVGIQFEEKSEMPDSATVP 496 + ++ E+PD + +P Sbjct: 441 PIKLEDYSADEIPDPSIIP 459 Score = 43.7 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 29/194 (14%), Positives = 51/194 (26%), Gaps = 47/194 (24%) Query: 8 EAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKG---------- 57 E +F ++ + + + + + +T W E + +G Sbjct: 324 ETLFGHQDEILDIDALGQERCVSVGARDRTARYWKVPEESQLVFRGGGEGGSSNTKKHKL 383 Query: 58 ----------HEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTI 107 HE + V + D D V+ S++ + +W L I I Sbjct: 384 PPGMDPASAAHEGSMDRVAMI-DDDMFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPPI 442 Query: 108 V------------------------ALSALP--SLISVGCADGTISIWRQNIQNDEFGLA 141 AL LP LI G DG I +WR + + Sbjct: 443 KLEDYSADEIPDPSIIPAPQPRGITALRTLPYSDLIFSGSWDGCIRVWRLSEDKRKLEAV 502 Query: 142 HEFTIKKGFFYPLC 155 + Sbjct: 503 GILGVGSETCENST 516 >3ODT-A nrPDB Length = 313 Score = 83.4 bits (204), Expect = 4e-16, Method: Composition-based stats. Identities = 44/310 (14%), Positives = 91/310 (29%), Gaps = 50/310 (16%) Query: 9 AIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFV 68 A G ++ + K+ + T+ LW + V T +G + V + Sbjct: 12 ATLKGHDQDVRDVVAVDDSKVASVSRDGTVRLWSKDDQWLGTVVYTGQG---FLNSVCYD 68 Query: 69 PDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISI 128 + + ++ +D + S + T+ + + +LS ++ G D T + Sbjct: 69 SEKELLLFGGKDTMINGVPLFATSGEDPLYTLIGHQGNVCSLSFQDGVVISGSWDKTAKV 128 Query: 129 WRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDS- 187 W++ + +S S E K+L A + ++ ++ Sbjct: 129 WKEGSLVYNLQ-----AHNASVWDAKVVSFS---ENKFLTASADKTIKLWQNDKVIKTFS 180 Query: 188 ------------------------------GIEKCRVVAELEGHEDWVKSLAFRHQETPG 217 + V+ EGHE +V + Sbjct: 181 GIHNDVVRHLAVVDDGHFISCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGD-- 238 Query: 218 DYLLCSGSQDRYIRLWRIRI---NDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFE 274 + S +DR +R+W +I + +SN D L + E Sbjct: 239 ---IVSCGEDRTVRIWSKENGSLKQVITLPAISIWSVDCMSNGDIIVGSSDNLVRIFSQE 295 Query: 275 ALIMGHDDWI 284 +D I Sbjct: 296 KSRWASEDEI 305 Score = 77.2 bits (188), Expect = 3e-14, Method: Composition-based stats. Identities = 47/283 (16%), Positives = 101/283 (35%), Gaps = 36/283 (12%) Query: 49 KGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIV 108 + ATLKGH+ +V V V DS + S S D V++W D + T Q + ++ Sbjct: 8 YQLSATLKGHDQDVRDVVAVDDSK-VASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSV- 65 Query: 109 ALSALPSLISVGCADGTIS---IWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKK 165 + L+ G D I+ ++ + ++ + L +G L Sbjct: 66 CYDSEKELLLFGGKDTMINGVPLFATSGEDPLYTLI----GHQGNVCSLSFQDG------ 115 Query: 166 YLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGS 225 ++ G + + ++ +V L+ H V + S Sbjct: 116 -VVISGSWDKTAKVW---------KEGSLVYNLQAHNASVWDAKVVSFSENK---FLTAS 162 Query: 226 QDRYIRLW--RIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFE-----ALIM 278 D+ I+LW I + + L ++ + + +D L ++ Sbjct: 163 ADKTIKLWQNDKVIKTFSGIHNDVVRHLAVVDDGHFISCSNDGLIKLVDMHTGDVLRTYE 222 Query: 279 GHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSL 321 GH+ ++ ++ + +++ D ++ +W + S V +L Sbjct: 223 GHESFVYCIKLLPNG-DIVSCGEDRTVRIWSKENGSLKQVITL 264 Score = 68.8 bits (166), Expect = 9e-12, Method: Composition-based stats. Identities = 53/328 (16%), Positives = 119/328 (36%), Gaps = 50/328 (15%) Query: 94 LQCIQTIQHYSKTIVALSALP-SLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFY 152 Q T++ + + + + A+ S ++ DGT+ +W ++ Sbjct: 8 YQLSATLKGHDQDVRDVVAVDDSKVASVSRDGTVRLWSKD--------DQWLGTVVYTGQ 59 Query: 153 PLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRH 212 S+ EK+ LL G + + F S + L GH+ V SL+F+ Sbjct: 60 GFLNSVCYDSEKELLLFGGKDTMINGVPLFATSGEDP-----LYTLIGHQGNVCSLSFQ- 113 Query: 213 QETPGDYLLCSGSQDRYIRLWR----IRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELR 268 D ++ SGS D+ ++W+ + + S D+K ++ NK D ++ Sbjct: 114 -----DGVVISGSWDKTAKVWKEGSLVYNLQAHNASVWDAKVVSFSENKFLTASADKTIK 168 Query: 269 VGINFEALIMG---HDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGE 325 + N + + H+D + L + ++ + D + + + + Sbjct: 169 LWQNDKVIKTFSGIHNDVVRHLAVVDDG-HFISCSNDGLIKLVDMHTGDVLR-------- 219 Query: 326 MSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGAT 385 F C+ ++ G+ + R+W +K+N Q + + + Sbjct: 220 --------TYEGHESFVYCIKLLPNGD--IVSCGEDRTVRIW-SKENGSLKQVITLPAIS 268 Query: 386 KDVTDIAWSPSGEYLLATSLDQTTRLFA 413 + + +G+ ++ S D R+F+ Sbjct: 269 --IWSVDCMSNGD-IIVGSSDNLVRIFS 293 Score = 61.8 bits (148), Expect = 1e-09, Method: Composition-based stats. Identities = 52/294 (17%), Positives = 101/294 (34%), Gaps = 60/294 (20%) Query: 192 CRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW--RIRINDLIDDSEE--- 246 ++ A L+GH+ R D + S S+D +RLW + + + + Sbjct: 8 YQLSATLKGHDQ-----DVRDVVAVDDSKVASVSRDGTVRLWSKDDQWLGTVVYTGQGFL 62 Query: 247 -----DSKKLTLLSNKQYKFQIDDEL--RVGINFEALIMGHDDWISSLQWHESRLQLLAA 299 DS+K LL + L G + ++GH + SL + + +++ Sbjct: 63 NSVCYDSEKELLLFGGKDTMINGVPLFATSGEDPLYTLIGHQGNVCSLSFQDG--VVISG 120 Query: 300 TADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFW--SCLWFTHERMDFFLT 357 + D + VW G V +L+ + W + F+ + FLT Sbjct: 121 SWDKTAKVW----KEGSLVYNLQ-------------AHNASVWDAKVVSFSENK---FLT 160 Query: 358 NGKTGSWRMWATKDNIICDQRLGISG-ATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWI 416 + ++W I SG V +A G ++ + S D +L Sbjct: 161 ASADKTIKLWQNDKVIK-----TFSGIHNDVVRHLAVVDDGHFI-SCSNDGLIKLVDMHT 214 Query: 417 YDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKG 470 D + H + C++ + + VS G+++ +R + G Sbjct: 215 GDV------------LRTYEGHESFVYCIKLLPNGDIVSCGEDRTVRIWSKENG 256 Score = 48.7 bits (114), Expect = 9e-06, Method: Composition-based stats. Identities = 44/230 (19%), Positives = 81/230 (35%), Gaps = 38/230 (16%) Query: 553 KLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRL 612 +Y + + +++L+ + + + +F+T + + L H + L Sbjct: 54 VVYTGQGFLNSVCYDSEKELLLFGGKDTMING--VPLFAT-SGEDPLYTLIGHQGNVCSL 110 Query: 613 KFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVT 672 F DG ++S D+ +W+ N + H +WDA N F+T Sbjct: 111 SFQ-DG-VVISGSWDKTAKVWKEGS-------LVYNLQAHNASVWDAKVVSF-SENKFLT 160 Query: 673 ASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLY 732 AS DKT+K+W++ K + H V +++ D +G I L Sbjct: 161 ASADKTIKLWQNDKVIKTFSGI-----HNDVVRHLAVVDDGHFISC-----SNDGLIKLV 210 Query: 733 SYTLGKFELITQLNED-------------ITPADKITRLRWSHLKRNGKL 769 G + +E ++ + T WS K NG L Sbjct: 211 DMHTGDVLRTYEGHESFVYCIKLLPNGDIVSCGEDRTVRIWS--KENGSL 258 Score = 47.6 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 46/305 (15%), Positives = 94/305 (30%), Gaps = 38/305 (12%) Query: 355 FLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAP 414 + + G+ R+W+ D + G + + + E LL D Sbjct: 32 VASVSRDGTVRLWSKDDQWLGTVVYTGQGF---LNSVCYDSEKELLLFGGKDTMIN--GV 86 Query: 415 WIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKGVAGM 474 ++ SG + Q + +C + D +SG +K + + V + Sbjct: 87 PLFATSGEDP----LYTLIGHQGN----VCSLSFQDGVVISGSWDKTAKVWKEGSLVYNL 138 Query: 475 LQKFVGI------QFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITD 528 + F E + SA + N D + + D Sbjct: 139 QAHNASVWDAKVVSFSENKFLTASADKTIKLWQN----DKVIKTFSGIHNDVVRHLAVVD 194 Query: 529 PLSLLECPPMEDQLQRHLLWPEVEKLY---GHGFEITCLDISPDQKLIASACRSNNVQNA 585 + C D L + + + L GH + C+ + P+ +++ ++ Sbjct: 195 DGHFISCS--NDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGDIVSCG------EDR 246 Query: 586 VIRIFSTENWLEIKP-ALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFEL 644 +RI+S EN + LP S+ + D ++ D ++ + E Sbjct: 247 TVRIWSKENGSLKQVITLPAISIWSVDCMSNGD---IIVGSSDNLVRIFSQEKSRWASED 303 Query: 645 RFKNE 649 K E Sbjct: 304 EIKGE 308 >4XYI-A nrPDB Length = 430 Score = 83.0 bits (203), Expect = 4e-16, Method: Composition-based stats. Identities = 35/228 (15%), Positives = 78/228 (34%), Gaps = 28/228 (12%) Query: 25 KVKKIVAFGAGKTIALWD-------PIEPNNKGVYATLKGHEAEVTCVRFV-PDSDFMVS 76 + + +I +WD + + + H A V ++F + S Sbjct: 194 QEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEALLTS 253 Query: 77 ASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP---SLISVGCADGTISIWRQNI 133 S+D ++I S Q ++ + + + ++ P L++ AD T+++W Sbjct: 254 VSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALWDL-- 311 Query: 134 QNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASF-------ILSD 186 H + Y + S + +L T+ V + + D Sbjct: 312 -RRLNQRLHTLEGHEDEVYNVQWS----PHDEPILVTSSTDRRVCVWDLSKIGEEQTVED 366 Query: 187 SGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWR 234 S ++ GH + V L++ ++L S + D +++W Sbjct: 367 SEDGAPELMFMHGGHTNRVSDLSWNP---NNKWVLASLADDNILQIWS 411 Score = 82.6 bits (202), Expect = 6e-16, Method: Composition-based stats. Identities = 52/334 (15%), Positives = 113/334 (33%), Gaps = 71/334 (21%) Query: 102 HYSKTIVALSA---LPSLISVGCADGTISIWRQNI--QNDEFGLAHEFTIKKGFFYPLCL 156 H+ + P +I+ +G I+ N+ + H+ ++ L Sbjct: 129 HHEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGL 188 Query: 157 SLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKC---RVVAELEGHEDWVKSLAFRHQ 213 + ++E LA G + ++ + +EK V+ H V L F Q Sbjct: 189 GWNFIQEG--TLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQ 246 Query: 214 ETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINF 273 LL S S D +++ R L + Sbjct: 247 HEA---LLTSVSDDCTLQIHDTR------------------------------LPSSSSA 273 Query: 274 EALIMGHDDWISSLQWHESRLQLL-AATADTSLMVWEPDETSGIWVCSLRLGEMSSKGAS 332 + H+ ++ + ++ LL A+AD ++ +W+ ++ Sbjct: 274 SQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALWDL--------------RRLNQRLH 319 Query: 333 TATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWAT----KDNIICDQRLGIS------ 382 T G ++ W H+ +T+ +W ++ + D G Sbjct: 320 TLEGHEDEVYNVQWSPHD-EPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMH 378 Query: 383 -GATKDVTDIAWSPSGEYLLAT-SLDQTTRLFAP 414 G T V+D++W+P+ +++LA+ + D ++++P Sbjct: 379 GGHTNRVSDLSWNPNNKWVLASLADDNILQIWSP 412 Score = 81.1 bits (198), Expect = 2e-15, Method: Composition-based stats. Identities = 57/340 (16%), Positives = 110/340 (32%), Gaps = 59/340 (17%) Query: 57 GHEAEVTCVRFVPDS-DFMVSASEDHHVKIWKFTDYSHLQCIQT-----IQHYSKTIVAL 110 HE +V RF+P + D + + + + I+ Y +QT ++H++ L Sbjct: 129 HHEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGL 188 Query: 111 SAL---PSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCL--SLSKVEEKK 165 ++ G D +I +W ++ + + + + L + + Sbjct: 189 GWNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHE 248 Query: 166 YLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGS 225 LL + + I L S + V + HE V +AF DYLL + S Sbjct: 249 ALLTSVSDDCTLQIHDTRLPSSSSAS-QCV---KAHEQPVNGVAFNPF---NDYLLATAS 301 Query: 226 QDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWIS 285 D + LW +R +++ L + GH+D + Sbjct: 302 ADHTVALWDLR-------------------------RLNQRLHT-------LEGHEDEVY 329 Query: 286 SLQWHE-SRLQLLAATADTSLMVWE---PDETSGIWVCSLRLGEMSSKGASTATGSSGGF 341 ++QW L+ ++ D + VW+ E + E+ G Sbjct: 330 NVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMF-----MHGGHTNR 384 Query: 342 WSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGI 381 S L + + ++W+ I L I Sbjct: 385 VSDLSWNPNNKWVLASLADDNILQIWSPSKVIWASDSLKI 424 Score = 61.1 bits (146), Expect = 2e-09, Method: Composition-based stats. Identities = 41/229 (17%), Positives = 79/229 (34%), Gaps = 34/229 (14%) Query: 541 QLQRHLLWPEVEKLYGHGFEITCLDIS-PDQKLIASACRSNNVQNAVIRIFSTENWLEIK 599 L++ + V + H + L + L+ S +Q R+ S+ + + Sbjct: 218 SLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEALLTSVSDDCTLQIHDTRLPSSSSASQ-- 275 Query: 600 PALPFHSLTITRLKFSKDGKFL-LSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWD 658 + H + + F+ +L + D ALW+ R + H +++ Sbjct: 276 -CVKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLR----RLNQRLHTLEGHEDEVYN 330 Query: 659 ADWAPLEFGNVFVTASRDKTVKVWRHQK-------EPADDYVLEASI---KHTKAVTAIS 708 W+P + + VT+S D+ V VW K E ++D E HT V+ +S Sbjct: 331 VQWSPHDEP-ILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLS 389 Query: 709 IHDSMIREKILISVGLENGEIYLYSYTLGKFELITQLNEDITPADKITR 757 + N + L S I ++ I +D + Sbjct: 390 WNP--------------NNKWVLASLADDNILQIWSPSKVIWASDSLKI 424 Score = 50.7 bits (119), Expect = 3e-06, Method: Composition-based stats. Identities = 40/206 (19%), Positives = 74/206 (35%), Gaps = 23/206 (11%) Query: 269 VGINFEALIMGHDDWISSLQWH--ESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEM 326 V +A + H L W+ + L T DTS+ VW+ S S+ + + Sbjct: 170 VQTGHQACLRHHTSEGFGLGWNFIQEGT-LATGTEDTSICVWDIKGKSLSLEKSIDVAPV 228 Query: 327 SSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATK 386 S TA + L F + + + ++ T+ + + Sbjct: 229 SVYHRHTAVVND------LQFHLQHEALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQ 282 Query: 387 DVTDIAWSPSGEYLLAT-SLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICV 445 V +A++P +YLLAT S D T L+ +R H + H ++ V Sbjct: 283 PVNGVAFNPFNDYLLATASADHTVALWDL--------RRLNQRLHTL---EGHEDEVYNV 331 Query: 446 E--TVTDTRFVSGGDEKILRSFDLPK 469 + + V+ ++ + +DL K Sbjct: 332 QWSPHDEPILVTSSTDRRVCVWDLSK 357 Score = 48.4 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 13/94 (13%), Positives = 35/94 (37%), Gaps = 13/94 (13%) Query: 15 NKQTQVSDI-HKVKKIVAFGAGKTIALWDPIEPNNKGVYATLK-----------GHEAEV 62 ++ V H +V + + +WD + + + GH V Sbjct: 326 DEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRV 385 Query: 63 TCVRFVPDSDF-MVSASEDHHVKIWKFTDYSHLQ 95 + + + P++ + + S ++D+ ++IW + Sbjct: 386 SDLSWNPNNKWVLASLADDNILQIWSPSKVIWAS 419 >6CB1-s nrPDB Length = 569 Score = 81.1 bits (198), Expect = 2e-15, Method: Composition-based stats. Identities = 47/384 (12%), Positives = 111/384 (28%), Gaps = 68/384 (17%) Query: 50 GVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHL---QCIQTIQHYSKT 106 GH+ +V + P ++ + S+D V++W+ + I ++ Sbjct: 190 RCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH 249 Query: 107 IVALSALPS----LISVGCADGTIS----IWRQNIQNDEFGLAH------EFTIKKGFFY 152 I + P +++V + I+ +I+N+ F K Sbjct: 250 IECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNL 309 Query: 153 PLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKC-------RVVAELEGHEDWV 205 + + E+ + A V + + + V +L H Sbjct: 310 EVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGD 369 Query: 206 KSLAFRHQETPGDYLLCSGSQ------------------------------DRYIRLWRI 235 + + L+ S+ RY+R++ + Sbjct: 370 YFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYVRIYDL 429 Query: 236 RINDLIDDSEEDS---KKLTLLSNKQYKFQ-------IDDELRVGINFEALIMGHDDWIS 285 L+ + K+ + + +L + + H+ + Sbjct: 430 SQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVR 489 Query: 286 SLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCL 345 S+ +H+ +A D ++ V+ + + + G +S G + Sbjct: 490 SVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVI--NSLGVLDAI 547 Query: 346 WFTHERMDFFLTNGKTGSWRMWAT 369 W H R + + G + R+W T Sbjct: 548 W--HPREAWLFSAGADNTARLWTT 569 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 32/238 (13%), Positives = 69/238 (28%), Gaps = 38/238 (15%) Query: 520 NKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRS 579 N P++ P L P + GH ++ L I P +A+ Sbjct: 172 NSLIPELPSPKDLRPFPIRCSTIYA-----------GHKGKVRTLSIDPSGLWLATGS-- 218 Query: 580 NNVQNAVIRIFSTENWLEIKPAL-----PFHSLTITRLKFSKDGK--FLLSVCRDRKWAL 632 + +R++ E+ I ++++ D L + + Sbjct: 219 ---DDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIHLI 275 Query: 633 ------------WERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVK 680 + +ED F K + + + N + K V Sbjct: 276 VPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQVA 335 Query: 681 VWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGK 738 W + + + +I K V +S H + ++V ++G + + + K Sbjct: 336 QWNKPSQKQLEKDICITISCKKTVKKLSWH---RKGDYFVTVQPDSGNTSVLIHQVSK 390 Score = 31.8 bits (70), Expect = 1.2, Method: Composition-based stats. Identities = 17/111 (15%), Positives = 34/111 (30%), Gaps = 20/111 (18%) Query: 540 DQLQRHLLWPEV-------EKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFST 592 + +LW ++ + L H + ++ L +SA + + + Sbjct: 460 SSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIH---VFHATV 516 Query: 593 ENWLEIKPA------LPFH----SLTITRLKFSKDGKFLLSVCRDRKWALW 633 + + P L H SL + + +L S D LW Sbjct: 517 YDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 567 >2PM9-A nrPDB Length = 416 Score = 80.3 bits (196), Expect = 3e-15, Method: Composition-based stats. Identities = 44/335 (13%), Positives = 109/335 (32%), Gaps = 42/335 (12%) Query: 30 VAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFT 89 F ++ LW + +++ A+L+ + + ++ + A ++ ++++ Sbjct: 39 ANFSTDSSLELWSLLAADSEKPIASLQVDSKF-NDLDWSHNNKIIAGALDNGSLELYSTN 97 Query: 90 DYSH----LQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFT 145 + ++ + KT+ + ++++ G +G I IW N + T Sbjct: 98 EANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLT 157 Query: 146 IKKGFFYPLCL-SLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDW 204 + + SL+ + ++ A G++ I I + G + Sbjct: 158 PGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKAKKEVI-HLSYTSPNSGIKQQ 216 Query: 205 VKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQID 264 + + + + + D I +W +R + Sbjct: 217 LSVVEWHPKNSTRVATATGSDNDPSILIWDLRNAN------------------------- 251 Query: 265 DELRVGINFEALIMGHDDWISSLQW-HESRLQLLAATADTSLMVWEPDETSGIWVCSLRL 323 + L GH I SL W H+ LL++ D ++++W P+ + R Sbjct: 252 ------TPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQFPARG 305 Query: 324 GEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTN 358 + + ++C F ++ L N Sbjct: 306 NWC---FKTKFAPEAPDLFACASFDNKIEVQTLQN 337 Score = 59.9 bits (143), Expect = 4e-09, Method: Composition-based stats. Identities = 21/127 (16%), Positives = 40/127 (31%), Gaps = 15/127 (11%) Query: 12 IGANKQTQVSDIH--KVKKIVAFGA---GKTIALWDPIEPNNKGVYATL-KGHEAEVTCV 65 G +Q V + H ++ +I +WD N TL +GH+ + + Sbjct: 211 SGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDL--RNANTPLQTLNQGHQKGILSL 268 Query: 66 RFVP-DSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTI---VALSALPSLISVGC 121 + D ++S+ D+ V +W + P L + Sbjct: 269 DWCHQDEHLLLSSGRDNTVLLWNPESAEQ---LSQFPARGNWCFKTKFAPEAPDLFACAS 325 Query: 122 ADGTISI 128 D I + Sbjct: 326 FDNKIEV 332 Score = 54.9 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 49/305 (16%), Positives = 99/305 (32%), Gaps = 43/305 (14%) Query: 115 SLISVGCADGTISI-WRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVE--EKKYLLAIG 171 L+ G GT+ + + + + L + K + + ++ ++A Sbjct: 26 PLLVSGTVSGTVDANFSTDSSLELWSLLAADSEKPIASLQVDSKFNDLDWSHNNKIIAGA 85 Query: 172 GTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIR 231 N ++ + S +++ I +A H VK++ F ++ D +L SG + I Sbjct: 86 LDNGSLELYSTNEANNAINS---MARFSNHSSSVKTVKFNAKQ---DNVLASGGNNGEIF 139 Query: 232 LWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHE 291 +W + +E S L M D + SL W++ Sbjct: 140 IWDM-----NKCTESPSNYTPLTP-------------------GQSMSSVDEVISLAWNQ 175 Query: 292 SRLQLL-AATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHE 350 S + +A + +W+ + S K + Sbjct: 176 SLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPK-------NST 228 Query: 351 RMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLL-ATSLDQTT 409 R+ + S +W ++ Q L G K + + W E+LL ++ D T Sbjct: 229 RVATATGSDNDPSILIWDLRNANTPLQTLN-QGHQKGILSLDWCHQDEHLLLSSGRDNTV 287 Query: 410 RLFAP 414 L+ P Sbjct: 288 LLWNP 292 Score = 48.0 bits (112), Expect = 2e-05, Method: Composition-based stats. Identities = 36/264 (13%), Positives = 83/264 (31%), Gaps = 36/264 (13%) Query: 225 SQDRYIRLWRI------------RINDLIDDSEEDSKKLTLLS---NKQYKFQIDDELRV 269 S D + LW + +++ +D + + N + +E Sbjct: 42 STDSSLELWSLLAADSEKPIASLQVDSKFNDLDWSHNNKIIAGALDNGSLELYSTNEANN 101 Query: 270 GINFEALIMGHDDWISSLQWH-ESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSS 328 IN A H + +++++ + L + + + +W+ ++ C+ + Sbjct: 102 AINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNK------CTESPSNYTP 155 Query: 329 KGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDN---IICDQRLGISGAT 385 + S S W F + G + +W K I SG Sbjct: 156 LTPGQSMSSVDEVISLAW-NQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIK 214 Query: 386 KDVTDIAWSPSG--EYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHG-YDM 442 + ++ + W P AT D + I+D + T ++ + I Sbjct: 215 QQLSVVEWHPKNSTRVATATGSDNDPSIL---IWDLRNANTPLQTLNQGHQKGILSLDW- 270 Query: 443 ICVETVTDTRFVSGGDEKILRSFD 466 C + + +S G + + ++ Sbjct: 271 -CHQ--DEHLLLSSGRDNTVLLWN 291 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 33/225 (14%), Positives = 69/225 (30%), Gaps = 33/225 (14%) Query: 564 LDISPDQKLIASACRSNNVQNAVIRIFSTE---NWLEIKPALPFHSLTITRLKFSK-DGK 619 LD S + K+IA A + N + ++ST N + HS ++ +KF+ Sbjct: 73 LDWSHNNKIIAGA-----LDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDN 127 Query: 620 FLLSVCRDRKWALWERNMEDNTFELRFKNEKPH----TRIIWDADWAPLEFGNVFVTASR 675 L S + + +W+ N + + W +VF +A Sbjct: 128 VLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWN-QSLAHVFASAGS 186 Query: 676 DKTVKVWRHQ--KEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLY- 732 +W + KE + + ++ + H + + I ++ Sbjct: 187 SNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWD 246 Query: 733 -------------SYTLGKFELITQLNED---ITPADKITRLRWS 761 + G L ++ ++ T L W+ Sbjct: 247 LRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWN 291 >6C0F-s nrPDB Length = 807 Score = 80.3 bits (196), Expect = 3e-15, Method: Composition-based stats. Identities = 47/384 (12%), Positives = 111/384 (28%), Gaps = 68/384 (17%) Query: 50 GVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHL---QCIQTIQHYSKT 106 GH+ +V + P ++ + S+D V++W+ + I ++ Sbjct: 428 RCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH 487 Query: 107 IVALSALPS----LISVGCADGTIS----IWRQNIQNDEFGLAH------EFTIKKGFFY 152 I + P +++V + I+ +I+N+ F K Sbjct: 488 IECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNL 547 Query: 153 PLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKC-------RVVAELEGHEDWV 205 + + E+ + A V + + + V +L H Sbjct: 548 EVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGD 607 Query: 206 KSLAFRHQETPGDYLLCSGSQ------------------------------DRYIRLWRI 235 + + L+ S+ RY+R++ + Sbjct: 608 YFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYVRIYDL 667 Query: 236 RINDLIDDSEEDS---KKLTLLSNKQYKFQ-------IDDELRVGINFEALIMGHDDWIS 285 L+ + K+ + + +L + + H+ + Sbjct: 668 SQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVR 727 Query: 286 SLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCL 345 S+ +H+ +A D ++ V+ + + + G +S G + Sbjct: 728 SVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVI--NSLGVLDAI 785 Query: 346 WFTHERMDFFLTNGKTGSWRMWAT 369 W H R + + G + R+W T Sbjct: 786 W--HPREAWLFSAGADNTARLWTT 807 Score = 39.9 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 32/238 (13%), Positives = 69/238 (28%), Gaps = 38/238 (15%) Query: 520 NKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRS 579 N P++ P L P + GH ++ L I P +A+ Sbjct: 410 NSLIPELPSPKDLRPFPIRCSTIYA-----------GHKGKVRTLSIDPSGLWLATGS-- 456 Query: 580 NNVQNAVIRIFSTENWLEIKPAL-----PFHSLTITRLKFSKDGK--FLLSVCRDRKWAL 632 + +R++ E+ I ++++ D L + + Sbjct: 457 ---DDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIHLI 513 Query: 633 ------------WERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVK 680 + +ED F K + + + N + K V Sbjct: 514 VPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQVA 573 Query: 681 VWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGK 738 W + + + +I K V +S H + ++V ++G + + + K Sbjct: 574 QWNKPSQKQLEKDICITISCKKTVKKLSWH---RKGDYFVTVQPDSGNTSVLIHQVSK 628 Score = 31.4 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 17/111 (15%), Positives = 34/111 (30%), Gaps = 20/111 (18%) Query: 540 DQLQRHLLWPEV-------EKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFST 592 + +LW ++ + L H + ++ L +SA + + + Sbjct: 698 SSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIH---VFHATV 754 Query: 593 ENWLEIKPA------LPFH----SLTITRLKFSKDGKFLLSVCRDRKWALW 633 + + P L H SL + + +L S D LW Sbjct: 755 YDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 >6EM1-m nrPDB Length = 807 Score = 79.9 bits (195), Expect = 4e-15, Method: Composition-based stats. Identities = 47/384 (12%), Positives = 111/384 (28%), Gaps = 68/384 (17%) Query: 50 GVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHL---QCIQTIQHYSKT 106 GH+ +V + P ++ + S+D V++W+ + I ++ Sbjct: 428 RCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYH 487 Query: 107 IVALSALPS----LISVGCADGTIS----IWRQNIQNDEFGLAH------EFTIKKGFFY 152 I + P +++V + I+ +I+N+ F K Sbjct: 488 IECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNL 547 Query: 153 PLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKC-------RVVAELEGHEDWV 205 + + E+ + A V + + + V +L H Sbjct: 548 EVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGD 607 Query: 206 KSLAFRHQETPGDYLLCSGSQ------------------------------DRYIRLWRI 235 + + L+ S+ RY+R++ + Sbjct: 608 YFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYVRIYDL 667 Query: 236 RINDLIDDSEEDS---KKLTLLSNKQYKFQ-------IDDELRVGINFEALIMGHDDWIS 285 L+ + K+ + + +L + + H+ + Sbjct: 668 SQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVR 727 Query: 286 SLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCL 345 S+ +H+ +A D ++ V+ + + + G +S G + Sbjct: 728 SVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVI--NSLGVLDAI 785 Query: 346 WFTHERMDFFLTNGKTGSWRMWAT 369 W H R + + G + R+W T Sbjct: 786 W--HPREAWLFSAGADNTARLWTT 807 Score = 39.9 bits (91), Expect = 0.005, Method: Composition-based stats. Identities = 32/238 (13%), Positives = 69/238 (28%), Gaps = 38/238 (15%) Query: 520 NKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRS 579 N P++ P L P + GH ++ L I P +A+ Sbjct: 410 NSLIPELPSPKDLRPFPIRCSTIYA-----------GHKGKVRTLSIDPSGLWLATGS-- 456 Query: 580 NNVQNAVIRIFSTENWLEIKPAL-----PFHSLTITRLKFSKDGK--FLLSVCRDRKWAL 632 + +R++ E+ I ++++ D L + + Sbjct: 457 ---DDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIHLI 513 Query: 633 ------------WERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVK 680 + +ED F K + + + N + K V Sbjct: 514 VPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQVA 573 Query: 681 VWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGK 738 W + + + +I K V +S H + ++V ++G + + + K Sbjct: 574 QWNKPSQKQLEKDICITISCKKTVKKLSWH---RKGDYFVTVQPDSGNTSVLIHQVSK 628 Score = 31.4 bits (69), Expect = 1.5, Method: Composition-based stats. Identities = 17/111 (15%), Positives = 34/111 (30%), Gaps = 20/111 (18%) Query: 540 DQLQRHLLWPEV-------EKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFST 592 + +LW ++ + L H + ++ L +SA + + + Sbjct: 698 SSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIH---VFHATV 754 Query: 593 ENWLEIKPA------LPFH----SLTITRLKFSKDGKFLLSVCRDRKWALW 633 + + P L H SL + + +L S D LW Sbjct: 755 YDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 >5OQL-d nrPDB Length = 446 Score = 79.9 bits (195), Expect = 4e-15, Method: Composition-based stats. Identities = 46/326 (14%), Positives = 99/326 (30%), Gaps = 45/326 (13%) Query: 57 GHEAEVTCV-RFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS 115 GH V + + + + S S D VK+W T + ++ + L+ Sbjct: 64 GHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEET--WRVAAHNNIVKGLTFTND 121 Query: 116 -LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTN 174 + DG I +W P + + G Sbjct: 122 KKLLSCATDG-IKLWDPYASPSNT----TPIATWQEGGPYTSLSFHRSANTFAASSGQGC 176 Query: 175 VNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWR 234 + ++ + I+ V D + + F ET ++ S + DR I L+ Sbjct: 177 IRIWDLEHSTAGQAIQWPSFV-------DTITDVCFNQVET---SVIGSVATDRSIILFD 226 Query: 235 IRINDLIDDS--EEDSKKLTLLSNKQYKFQIDDELRVGINFEALIM--------GHDDWI 284 +R N + + ++ + + E F+A GH + Sbjct: 227 LRTNMPVIKTVLHFACNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQKGHVAAV 286 Query: 285 SSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSC 344 +++ + +L++ + D ++ +W D V + + + Sbjct: 287 MDVEFSPTGEELVSGSYDRTIRLWRRDAGHSRDVYHTKRMQR--------------VFRT 332 Query: 345 LWFTHERMDFFLTNGKTGSWRMWATK 370 +W + + LT G+ R+W Sbjct: 333 MWTMDSK--YILTGSDDGNVRLWRAN 356 Score = 79.2 bits (193), Expect = 7e-15, Method: Composition-based stats. Identities = 24/109 (22%), Positives = 37/109 (33%), Gaps = 2/109 (1%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 + I ++D N KGH A V V F P + +VS S D +++W+ Sbjct: 255 LAVASEDHNIYIFDA--RNFDKALNIQKGHVAAVMDVEFSPTGEELVSGSYDRTIRLWRR 312 Query: 89 TDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDE 137 T + + I G DG + +WR N Sbjct: 313 DAGHSRDVYHTKRMQRVFRTMWTMDSKYILTGSDDGNVRLWRANASERS 361 Score = 79.2 bits (193), Expect = 7e-15, Method: Composition-based stats. Identities = 54/358 (15%), Positives = 96/358 (26%), Gaps = 88/358 (24%) Query: 7 PEAIFIGANKQTQV----SDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEV 62 P +G V D + + I + + +WD + + H V Sbjct: 56 PFLGQLGNGHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVA--AHNNIV 113 Query: 63 TCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSAL--PSLISVG 120 + F D ++S + D +K+W +LS + + Sbjct: 114 KGLTFTNDKK-LLSCATDG-IKLWDPYASPSNTTPIATWQEGGPYTSLSFHRSANTFAAS 171 Query: 121 CADGTISIWRQNIQNDE------------------------------------FGLAHEF 144 G I IW F L Sbjct: 172 SGQGCIRIWDLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNM 231 Query: 145 TIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDW 204 + K + C + + LA+ + N++I D + + +GH Sbjct: 232 PVIKTVLHFACNRIVFNPMEAMNLAVASEDHNIYIFDARNFD------KALNIQKGHVAA 285 Query: 205 VKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQID 264 V + F P L SGS DR IRLWR + + + Sbjct: 286 VMDVEFS----PTGEELVSGSYDRTIRLWR--------------------RDAGHSRDVY 321 Query: 265 DELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLR 322 R+ F + W +L + D ++ +W + + V + R Sbjct: 322 HTKRMQRVFRTM------------WTMDSKYILTGSDDGNVRLWRANASERSGVKATR 367 Score = 70.7 bits (171), Expect = 3e-12, Method: Composition-based stats. Identities = 36/243 (14%), Positives = 75/243 (30%), Gaps = 37/243 (15%) Query: 6 TPEAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYA--TLKGHEAEVT 63 TP A + T +S A I +WD + +T Sbjct: 145 TPIATWQEGGPYTSLSFHRSANTFAASSGQGCIRIWDLEHSTAGQAIQWPSFV---DTIT 201 Query: 64 CVRFVP-DSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSL-ISVGC 121 V F ++ + S + D + ++ ++ I+T+ H++ + + + ++ ++V Sbjct: 202 DVCFNQVETSVIGSVATDRSIILFDLRT--NMPVIKTVLHFACNRIVFNPMEAMNLAVAS 259 Query: 122 ADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIAS 181 D I I+ + + + + + L G + + + Sbjct: 260 EDHNIYIFDA--------RNFDKALNIQKGHVAAVMDVEFSPTGEELVSGSYDRTIRLWR 311 Query: 182 FILSDSGIEKCRVVAELEGHEDWVKSLA-----FRHQETPGDYLLCSGSQDRYIRLWRIR 236 GH V FR T + +GS D +RLWR Sbjct: 312 RDA---------------GHSRDVYHTKRMQRVFRTMWTMDSKYILTGSDDGNVRLWRAN 356 Query: 237 IND 239 ++ Sbjct: 357 ASE 359 Score = 69.2 bits (167), Expect = 7e-12, Method: Composition-based stats. Identities = 51/303 (16%), Positives = 93/303 (30%), Gaps = 50/303 (16%) Query: 200 GHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRIND----LIDDSEEDSKKLTLLS 255 GH V S+ + SGS D +++W + D + K LT + Sbjct: 64 GHVQGVYSMCKDKNSLN---CIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTFTN 120 Query: 256 NKQYK------FQIDDELRVGINFEALIMGHDDW-ISSLQWHESRLQLLAATADTSLMVW 308 +K+ ++ D N + + +SL +H S A++ + +W Sbjct: 121 DKKLLSCATDGIKLWDPYASPSNTTPIATWQEGGPYTSLSFHRSANTFAASSGQGCIRIW 180 Query: 309 EPD---ETSGIWVCSLRLGEMSSKGASTATGSSGGFWS------------------CLWF 347 + + I S T G + L F Sbjct: 181 DLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLHF 240 Query: 348 THERMDFFLTNGKTGSWRMWATKDNIICDQRLG-----ISGATKDVTDIAWSPSGEYLLA 402 R+ F + I + G V D+ +SP+GE L++ Sbjct: 241 ACNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPTGEELVS 300 Query: 403 TSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKIL 462 S D+T RL+ +G R++ R T+ ++G D+ + Sbjct: 301 GSYDRTIRLWRRD----AGHSRDVYHTKRMQRV-FRTMW-----TMDSKYILTGSDDGNV 350 Query: 463 RSF 465 R + Sbjct: 351 RLW 353 Score = 56.4 bits (134), Expect = 4e-08, Method: Composition-based stats. Identities = 25/101 (24%), Positives = 41/101 (40%), Gaps = 6/101 (5%) Query: 583 QNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTF 642 ++ I IF N+ + H + ++FS G+ L+S DR LW R+ + Sbjct: 260 EDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPTGEELVSGSYDRTIRLWRRDAGHSRD 319 Query: 643 ELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWR 683 K + R +W D +T S D V++WR Sbjct: 320 VYHTKRMQRVFRTMWTMDS------KYILTGSDDGNVRLWR 354 Score = 44.5 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 15/85 (17%), Positives = 31/85 (36%), Gaps = 5/85 (5%) Query: 555 YGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKF 614 GH + ++ SP + + S + IR++ + + R + Sbjct: 280 KGHVAAVMDVEFSPTGEELVSGSY-----DRTIRLWRRDAGHSRDVYHTKRMQRVFRTMW 334 Query: 615 SKDGKFLLSVCRDRKWALWERNMED 639 + D K++L+ D LW N + Sbjct: 335 TMDSKYILTGSDDGNVRLWRANASE 359 Score = 41.4 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 21/114 (18%), Positives = 46/114 (40%), Gaps = 13/114 (11%) Query: 621 LLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVK 680 L D +++ F+ +K H + D +++P G V+ S D+T++ Sbjct: 255 LAVASEDHNIYIFDAR----NFDKALNIQKGHVAAVMDVEFSP--TGEELVSGSYDRTIR 308 Query: 681 VWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSY 734 +WR + D HTK + + + K +++ ++G + L+ Sbjct: 309 LWRRDAGHSRDVY------HTKRMQRVFRTMWTMDSKYILTGS-DDGNVRLWRA 355 Score = 29.9 bits (65), Expect = 4.9, Method: Composition-based stats. Identities = 11/79 (13%), Positives = 22/79 (27%), Gaps = 4/79 (5%) Query: 644 LRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKA 703 + H + ++ N + S D VKVW + + + A H Sbjct: 57 FLGQLGNGHVQGVYSMC-KDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAA---HNNI 112 Query: 704 VTAISIHDSMIREKILISV 722 V ++ + Sbjct: 113 VKGLTFTNDKKLLSCATDG 131 >3JZG-A nrPDB Length = 402 Score = 78.8 bits (192), Expect = 8e-15, Method: Composition-based stats. Identities = 41/269 (15%), Positives = 82/269 (30%), Gaps = 46/269 (17%) Query: 2 VECITPEAIFIGANKQTQVSDIH--KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHE 59 ++CI ++G H +++ + LW+ ++ ++GH Sbjct: 141 MQCI---KHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHR 197 Query: 60 AEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQ--------------------- 98 EV + + ++S DH +K+W+ + I+ Sbjct: 198 DEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHF 257 Query: 99 ----TIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAH----EFTIKKGF 150 T + + + L LI + I W+ D+ TI F Sbjct: 258 PDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRF 317 Query: 151 FYPLCLSLSKVEEK---KYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHE--DWV 205 Y C + +LA+G +++ + D KC L H+ + Sbjct: 318 DYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKC---TTLTHHKCGAAI 374 Query: 206 KSLAFRHQETPGDYLLCSGSQDRYIRLWR 234 + +F +L + D I W Sbjct: 375 RQTSFSR----DSSILIAVCDDASIWRWD 399 Score = 49.9 bits (117), Expect = 4e-06, Method: Composition-based stats. Identities = 25/144 (17%), Positives = 54/144 (37%), Gaps = 17/144 (11%) Query: 338 SGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSG 397 G + L F + L+ K + R+W + + + G+ G +V + G Sbjct: 150 HGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLG 209 Query: 398 EYLLATSLDQTTRLF------------APWIYDASGRKREIAT----WHEFSRPQIHGYD 441 E +++ +D + +L+ + Y+ + R + + +FS IH Sbjct: 210 EKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNY 269 Query: 442 MICVETVTDTRFVSGGDEKILRSF 465 + CV + D +S E + + Sbjct: 270 VDCVRWLGD-LILSKSCENAIVCW 292 Score = 45.7 bits (106), Expect = 8e-05, Method: Composition-based stats. Identities = 52/403 (12%), Positives = 112/403 (27%), Gaps = 90/403 (22%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLK---GHEAEVTCVRFVPDSD----FMVSASEDH 81 G+ + + L++ + + E TC + DS+ + A Sbjct: 74 FATVGSNR-VTLYECHSQGEIRLLQSYVDADADENFYTC-AWTYDSNTSHPLLAVAGSRG 131 Query: 82 HVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP---SLISVGCADGTISIWRQNIQNDEF 138 ++I + +QCI+ + I L P +L+ D + +W Sbjct: 132 IIRI---INPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDT--- 185 Query: 139 GLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAEL 198 L F + G V A + L I C + Sbjct: 186 -LVAIFGGVE-----------------------GHRDEVLSADYDLLGEKIMSCGM---- 217 Query: 199 EGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQ 258 D ++LWRI ++ + NK Sbjct: 218 ----------------------------DHSLKLWRINSKRMM---NAIKESYDYNPNKT 246 Query: 259 YKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWV 318 + I ++ I H +++ ++W +L+ + + +++ W+P + + Sbjct: 247 NRPFISQKIHFPDFSTRDI--HRNYVDCVRW--LGDLILSKSCENAIVCWKPGKME-DDI 301 Query: 319 CSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQR 378 ++ E + S W + + G +W + + Sbjct: 302 DKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAK 361 Query: 379 LGISGATK---DVTDIAWSPSGEYLLATSLDQTTRLFAPWIYD 418 K + ++S L+A D + W +D Sbjct: 362 CTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASI-----WRWD 399 Score = 41.0 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 19/94 (20%), Positives = 36/94 (38%), Gaps = 4/94 (4%) Query: 545 HLLWPEVEKLYGHGFEITCLDISP-DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALP 603 + ++ GHG I L P D L+ S + + ++ I+ T+ + I + Sbjct: 138 PITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ---TDTLVAIFGGVE 194 Query: 604 FHSLTITRLKFSKDGKFLLSVCRDRKWALWERNM 637 H + + G+ ++S D LW N Sbjct: 195 GHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINS 228 Score = 29.5 bits (64), Expect = 5.7, Method: Composition-based stats. Identities = 13/77 (16%), Positives = 33/77 (42%), Gaps = 5/77 (6%) Query: 651 PHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIH 710 H I + + P + N+ ++ S+D +++W Q + + H V + Sbjct: 149 GHGNAINELKFHPRD-PNLLLSVSKDHALRLWNIQTDTLV-AIFGGVEGHRDEVLSA--- 203 Query: 711 DSMIREKILISVGLENG 727 D + + ++S G+++ Sbjct: 204 DYDLLGEKIMSCGMDHS 220 >5BJS-A nrPDB Length = 605 Score = 78.4 bits (191), Expect = 1e-14, Method: Composition-based stats. Identities = 22/115 (19%), Positives = 48/115 (41%), Gaps = 9/115 (7%) Query: 23 IHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMV-SASEDH 81 I + G + +++ E +Y TL GH + + P + +++ SAS+D Sbjct: 145 ITDQPLLCIAGNEGNVKVYNVTEG---KLYRTLVGHGGGINDLATSPANPYIIASASDDT 201 Query: 82 HVKIWKFTDYSHLQ---CIQTIQHYSKTIVALSALPS--LISVGCADGTISIWRQ 131 ++IW Q CI + +S +++++ + + D I++W Sbjct: 202 TIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWAL 256 Score = 71.9 bits (174), Expect = 1e-12, Method: Composition-based stats. Identities = 23/118 (19%), Positives = 46/118 (38%), Gaps = 14/118 (11%) Query: 29 IVAFGAGKTIALWDPI-EPNNKGVYATL--KGHEAEVTCVRFVPDSDFMVSASEDHHVKI 85 I + TI +W E + L +GH ++ V F + +++SA D + + Sbjct: 194 IASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINL 253 Query: 86 WKF----TDYSHLQCIQTIQHYSKT------IVALSALPSLISV-GCADGTISIWRQN 132 W ++ + + H+S + + ++ LI C + TI +WR Sbjct: 254 WALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAFYGDLILSRACHEDTIVLWRIE 311 Score = 64.9 bits (156), Expect = 1e-10, Method: Composition-based stats. Identities = 33/190 (17%), Positives = 67/190 (35%), Gaps = 14/190 (7%) Query: 69 PDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISI 128 D + A + +VK++ T+ + + + A P +I+ D TI I Sbjct: 146 TDQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRI 205 Query: 129 WRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSG 188 W ++++ + + LS++ + +Y+L+ G + + + + + Sbjct: 206 WSLAPEHEKQPCVCILGGEGHSYDL--LSVAFHDNGRYVLSAG-HDQVINLWALPEFPNE 262 Query: 189 IEKCRVVAELEG------HEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLID 242 + +V H + V +AF GD +L + I LWRI D Sbjct: 263 HMEIPIVIYYPHFSSSEIHNNLVDCVAFY-----GDLILSRACHEDTIVLWRIEGFSSDD 317 Query: 243 DSEEDSKKLT 252 T Sbjct: 318 PIPGPLDAPT 327 Score = 57.2 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 41/267 (15%), Positives = 82/267 (30%), Gaps = 48/267 (17%) Query: 207 SLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLL---SNKQYKFQI 263 + F PG + + + ++ + R+ D + + L+ N+ Sbjct: 82 DVKFYPYSPPGAPPVFAATSKKHAVICRL--TQTTDKDANPCEIIQLIRDDGNEANCASC 139 Query: 264 DDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRL 323 + + I G++ ++ V+ E Sbjct: 140 WSKDPITDQPLLCIAGNEG---------------------NVKVYNVTEG---------- 168 Query: 324 GEMSSKGASTATGSSGGFWSCLWFTHERMDFFL-TNGKTGSWRMWAT---KDNIICDQRL 379 K T G GG T + + + + R+W+ + C L Sbjct: 169 -----KLYRTLVGHGGGINDLA--TSPANPYIIASASDDTTIRIWSLAPEHEKQPCVCIL 221 Query: 380 GISGATKDVTDIAWSPSGEYLLATSLDQTTRLFA-PWIYDASGRKREIATWHEFSRPQIH 438 G G + D+ +A+ +G Y+L+ DQ L+A P + + + FS +IH Sbjct: 222 GGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIH 281 Query: 439 GYDMICVETVTDTRFVSGGDEKILRSF 465 + CV D E + + Sbjct: 282 NNLVDCVAFYGDLILSRACHEDTIVLW 308 Score = 56.8 bits (135), Expect = 3e-08, Method: Composition-based stats. Identities = 35/150 (23%), Positives = 58/150 (38%), Gaps = 14/150 (9%) Query: 552 EKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPAL-----PFHS 606 L GHG I L SP I ++ + IRI+S E +P + HS Sbjct: 172 RTLVGHGGGINDLATSPANPYIIASA----SDDTTIRIWSLAPEHEKQPCVCILGGEGHS 227 Query: 607 LTITRLKFSKDGKFLLSVCRDRKWALWE-RNMEDNTFELRFKNEKPH--TRIIWD--ADW 661 + + F +G+++LS D+ LW + E+ PH + I + D Sbjct: 228 YDLLSVAFHDNGRYVLSAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDC 287 Query: 662 APLEFGNVFVTASRDKTVKVWRHQKEPADD 691 + A + T+ +WR + +DD Sbjct: 288 VAFYGDLILSRACHEDTIVLWRIEGFSSDD 317 Score = 40.7 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 28/143 (19%), Positives = 45/143 (31%), Gaps = 16/143 (11%) Query: 562 TCLDISP--DQKLIASACRSNNVQNAVIRIFSTENWLEIKP--ALPFHSLTITRLKFSKD 617 +C P DQ L+ A NV N E K L H I L S Sbjct: 138 SCWSKDPITDQPLLCIAGNEGNV--------KVYNVTEGKLYRTLVGHGGGINDLATSPA 189 Query: 618 GKFL-LSVCRDRKWALWERNMEDNTFELR-FKNEKPHTRIIWDADWAPLEFGNVFVTASR 675 ++ S D +W E + H+ + A + G ++A Sbjct: 190 NPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSV--AFHDNGRYVLSAGH 247 Query: 676 DKTVKVWRHQKEPADDYVLEASI 698 D+ + +W + P + + I Sbjct: 248 DQVINLWALPEFPNEHMEIPIVI 270 Score = 36.0 bits (81), Expect = 0.066, Method: Composition-based stats. Identities = 15/77 (19%), Positives = 32/77 (41%), Gaps = 13/77 (16%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNKGV----------YATLKGHEAEVTCVRFVPDSDFM 74 + +++ G + I LW E N+ + +++ + H V CV F D + Sbjct: 238 NGRYVLSAGHDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAF--YGDLI 295 Query: 75 VS-ASEDHHVKIWKFTD 90 +S A + + +W+ Sbjct: 296 LSRACHEDTIVLWRIEG 312 >4J0X-A nrPDB Length = 451 Score = 78.4 bits (191), Expect = 1e-14, Method: Composition-based stats. Identities = 63/355 (17%), Positives = 121/355 (34%), Gaps = 49/355 (13%) Query: 99 TIQHYSKTI--VALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCL 156 T + + I VA S + G D + +W + K L L Sbjct: 109 TTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSP----VKVIPTKDRRGEVLSL 164 Query: 157 SLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETP 216 + K ++ Y F + I + + L GH D V+ ++ Sbjct: 165 AFRKNSDQLYASCA----------DFKIRTYSINQFSQLEILYGHHDIVEDIS----ALA 210 Query: 217 GDYLLCSGSQDRYIRLWRI--RINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFE 274 + + G++DR LW+I +E K L + K D E++ E Sbjct: 211 MERCVTVGARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESE 270 Query: 275 ALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTA 334 A + + I + + + + + ++ +W + I+ + G + + Sbjct: 271 APLFFCEGSIDVVSMVDD-FHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDI 329 Query: 335 TGSSGG---------------FWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRL 379 +G + FW + + F++ +GS ++W DN+ + L Sbjct: 330 SGETDEELRKRQLQGKKLLQPFWITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELL 389 Query: 380 G-ISGATKDVTDIAWSPSGEY-------LLATSLDQTTRLFAPWIYDASGRKREI 426 G +SGA VT I SG++ L + + + WI + SG + I Sbjct: 390 GELSGAKGVVTKIQVVESGKHGKEKFRILASIAKEHRL---GRWIANVSGARNGI 441 Score = 75.7 bits (184), Expect = 8e-14, Method: Composition-based stats. Identities = 60/346 (17%), Positives = 112/346 (32%), Gaps = 28/346 (8%) Query: 43 PIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQH 102 I + T +GH E+ V PD ++V+ D + +W S ++ I T + Sbjct: 98 YIPTSKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPT-KD 156 Query: 103 YSKTIVALSAL--PSLISVGCADGTISIWRQN-IQNDEFGLAHEFTIKKGFFYP--LCLS 157 +++L+ + CAD I + N E H ++ C++ Sbjct: 157 RRGEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVT 216 Query: 158 LS---------KVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSL 208 + K+ ++ L GG + ++ ++ + V + E + Sbjct: 217 VGARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFC 276 Query: 209 --AFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDE 266 + D+ +GS + I LW + I L S + D+E Sbjct: 277 EGSIDVVSMVDDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISGETDEE 336 Query: 267 LRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEM 326 LR ++ WI+SL ++ + SL VW+ + + LGE+ Sbjct: 337 LRKRQLQGKKLL-QPFWITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFEL---LGEL 392 Query: 327 SSKGASTATGSSGGFWSCLWFTHERMDF--FLTNGKTGSWRMWATK 370 S A G H + F + K W Sbjct: 393 -----SGAKGVVTKIQVVESGKHGKEKFRILASIAKEHRLGRWIAN 433 Score = 62.2 bits (149), Expect = 8e-10, Method: Composition-based stats. Identities = 42/369 (11%), Positives = 97/369 (26%), Gaps = 51/369 (13%) Query: 133 IQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKC 192 + + F + S + + ++ + +K Sbjct: 30 VGENNLTCISCFQPVLNKYTFEESSNGDKNKGRLFAYTVSKDLQLTKYDITDFSKRPKKL 89 Query: 193 RV---------------VAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRI 237 + EGH D + ++A +P + +G +DR + +W Sbjct: 90 KYAKGGAKYIPTSKHEYENTTEGHYDEILTVA----ASPDGKYVVTGGRDRKLIVWSTES 145 Query: 238 NDLID-----DSEEDSKKLTLLSNKQYKFQIDDELRVGI------NFEALIMGHDDWISS 286 + D + L N + + ++ + ++ GH D + Sbjct: 146 LSPVKVIPTKDRRGEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVED 205 Query: 287 LQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLW 346 + + D + M+W+ + + + + + G + Sbjct: 206 ISALAMERCVTVGARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKY 265 Query: 347 FTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLD 406 F G M + + WS + + + T Sbjct: 266 PDESEAPLFFCEGSIDVVSMVD---------DFHFITGSDNGNICLWSLAKKKPIFTERI 316 Query: 407 QTTRLFAPWIYDASGRKREIATWHEFSRPQIHG------YDMICVETVT-DTRFVSGGDE 459 L P D SG E E + Q+ G + + + + F+SG Sbjct: 317 AHGILPEPSFNDISGETDE-----ELRKRQLQGKKLLQPFWITSLYAIPYSNVFISGSWS 371 Query: 460 KILRSFDLP 468 L+ + + Sbjct: 372 GSLKVWKIS 380 Score = 58.8 bits (140), Expect = 1e-08, Method: Composition-based stats. Identities = 39/218 (17%), Positives = 74/218 (33%), Gaps = 25/218 (11%) Query: 555 YGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPA-LPFHSLTITRLK 613 GH EI + SPD K + + R + ++STE+ +K + L Sbjct: 111 EGHYDEILTVAASPDGKYVVTGGRDRKLI-----VWSTESLSPVKVIPTKDRRGEVLSLA 165 Query: 614 FSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTA 673 F K+ L + C D K + N L ++ D + L Sbjct: 166 FRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVE-------DISALAMERCVTVG 218 Query: 674 SRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGL---ENGEIY 730 +RD+T +W+ E + + + K + + E Sbjct: 219 ARDRTAMLWKIPDET------RLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAP 272 Query: 731 LYSYTLGKFELITQLNE--DITPADKITRLRWSHLKRN 766 L+ + G ++++ +++ IT +D WS K+ Sbjct: 273 LF-FCEGSIDVVSMVDDFHFITGSDNGNICLWSLAKKK 309 Score = 53.0 bits (125), Expect = 5e-07, Method: Composition-based stats. Identities = 74/421 (17%), Positives = 127/421 (30%), Gaps = 80/421 (19%) Query: 235 IRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRL 294 + D+ D S+ K +Y E +E GH D I ++ Sbjct: 74 LTKYDITDFSKRPKKLKYAKGGAKYIPTSKHE------YENTTEGHYDEILTVAASPDGK 127 Query: 295 QLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGG--FWSCLWFTHERM 352 ++ D L+VW + S + V + + + S A + + SC F Sbjct: 128 YVVTGGRDRKLIVWSTESLSPVKVIPTK--DRRGEVLSLAFRKNSDQLYASCADF----K 181 Query: 353 DFFLTNGKTGSWRMWATKDNIICD------QRLGISGATKDVTDIAWSPSGEYLLATSLD 406 + + + +I+ D +R GA + P L D Sbjct: 182 IRTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGARDRTAMLWKIPDETRLTFRGGD 241 Query: 407 QTTRLFAPWIY-DAS-GRKREIATWHEFSRPQIHGY-DMICVETVTDTRFVSGGDEKILR 463 + +L W+ +A G E+ E P + V V D F++G D + Sbjct: 242 EPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVSMVDDFHFITGSDNGNIC 301 Query: 464 SFDLPKGVAGMLQKFV-GIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKE 522 + L K ++ GI L + D + E DEE Sbjct: 302 LWSLAKKKPIFTERIAHGI------------------LPEPSFNDISGETDEEL------ 337 Query: 523 TPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNV 582 + QLQ L F IT L P + S S ++ Sbjct: 338 ---------------RKRQLQGKKLLQP--------FWITSLYAIPYSNVFISGSWSGSL 374 Query: 583 QNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKF-------LLSVCRDRKWALWER 635 + I E+ L +T+++ + GK L S+ ++ + W Sbjct: 375 KVWKIS--DNLRSFELLGELSGAKGVVTKIQVVESGKHGKEKFRILASIAKEHRLGRWIA 432 Query: 636 N 636 N Sbjct: 433 N 433 Score = 38.7 bits (88), Expect = 0.011, Method: Composition-based stats. Identities = 36/232 (15%), Positives = 75/232 (32%), Gaps = 44/232 (18%) Query: 8 EAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCV-R 66 E ++ + +S + + + +T LW T +G + + R Sbjct: 194 EILYGHHDIVEDISALAMERCVTVGARDRTAMLW----KIPDETRLTFRGGDEPQKLLRR 249 Query: 67 FVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTI 126 ++ ++ ED VK ++ C S +V++ I G +G I Sbjct: 250 WMKEN---AKEGEDGEVKYPDESEAPLFFC-----EGSIDVVSMVDDFHFI-TGSDNGNI 300 Query: 127 SIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSD 186 +W KK + ++ + E + G T+ L Sbjct: 301 CLWSLA--------------KKKPIFTERIAHGILPEPSFNDISGETDE-------ELRK 339 Query: 187 SGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRIN 238 ++ +++ W+ SL P + SGS +++W+I N Sbjct: 340 RQLQGKKLLQPF-----WITSL----YAIPYSNVFISGSWSGSLKVWKISDN 382 >3W15-A nrPDB Length = 368 Score = 78.4 bits (191), Expect = 1e-14, Method: Composition-based stats. Identities = 50/317 (15%), Positives = 100/317 (31%), Gaps = 61/317 (19%) Query: 27 KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDF-MVSASEDHHVKI 85 +++ T+ L+D A K HE EV + + +S+S D +KI Sbjct: 76 NQVLVAQGDGTLRLFDTTFKE--FPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKI 133 Query: 86 WKFTDYSHLQCI---------------------QTIQHYSK---TIVALSALP---SLIS 118 W L + ++ SK + P +L+ Sbjct: 134 WSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVL 193 Query: 119 VGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVF 178 + S++ + + + + F + G C + + Y++A GG + + Sbjct: 194 SCSGNSYASLFDIRLPSGKNQ--NNFLVHSGLEALTC---DFNKYRPYVVATGGVDNAIR 248 Query: 179 IASFILSDSGIE---KCRVVAEL-EGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWR 234 I + + + E+ H ++ + + + +L S S D R+WR Sbjct: 249 IWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSN---ILMSASYDMTCRIWR 305 Query: 235 IRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRL 294 ND + + YK D + I H +++ W Sbjct: 306 DLSND--------------GAKETYKTNSTDATKGSI---FNFTQHSEFVFGADWSLWGK 348 Query: 295 --QLLAATADTSLMVWE 309 + + D +L VW Sbjct: 349 PGYVASTAWDGNLFVWN 365 Score = 70.7 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 42/363 (11%), Positives = 97/363 (26%), Gaps = 74/363 (20%) Query: 35 GKTIALWDPIEPNNKGVYATLKGHEAEVTCVRF--VPDSDFMVSASEDHHVKIWKFTDYS 92 ++ + + + + + ++ +V+ D ++++ T Sbjct: 48 DRSGRIVEVNSFLTQDCL----------FDLAWNESHENQVLVAQG-DGTLRLFDTT--F 94 Query: 93 HLQCIQTIQHYSKTIVALSAL---PSLISVGCADGTISIWRQNIQNDEFGLAHEF----- 144 I + + + + + + DG+I IW + L Sbjct: 95 KEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITK 154 Query: 145 ----------------TIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSG 188 I K S ++ +L+ G + L D Sbjct: 155 MVDPLNAIILKKKSFTGISKNRNCVYQAQFSPH-DQNLVLSCSGNSYA------SLFDIR 207 Query: 189 IEKCRVVAELEGHED-WVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEED 247 + + H + F Y++ +G D IR+W IR+ + + Sbjct: 208 LPSGKNQNNFLVHSGLEALTCDFNKY---RPYVVATGGVDNAIRIWDIRMLNKNPGQLHN 264 Query: 248 SKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLL-AATADTSLM 306 S + + N H I + W +L +A+ D + Sbjct: 265 SSCINEIPN----------------------AHGLAIRKVTWSPHHSNILMSASYDMTCR 302 Query: 307 VWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMD-FFLTNGKTGSWR 365 +W G ++KG+ F ++ + + G+ Sbjct: 303 IWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLF 362 Query: 366 MWA 368 +W Sbjct: 363 VWN 365 Score = 56.8 bits (135), Expect = 4e-08, Method: Composition-based stats. Identities = 49/269 (18%), Positives = 86/269 (31%), Gaps = 44/269 (16%) Query: 156 LSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQET 215 L+ ++ E + L+A G + +F +F +A + HE V S + Sbjct: 68 LAWNESHENQVLVAQGDGTLRLFDTTFKEFP--------IAIFKEHEREVFSCNWNLVNR 119 Query: 216 PGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEA 275 S S D I++W +TL ++ D L I + Sbjct: 120 QN---FLSSSWDGSIKIWSPLRKQ---------SLMTLTPRPLEITKMVDPLNAIILKKK 167 Query: 276 LIMG---HDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGAS 332 G + + + Q+ D +L++ S + +RL S K + Sbjct: 168 SFTGISKNRNCVYQAQFSPH---------DQNLVL-SCSGNSYASLFDIRLP--SGKNQN 215 Query: 333 TATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGIS--------GA 384 SG F R T G + R+W + +L S Sbjct: 216 NFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAH 275 Query: 385 TKDVTDIAWSPSGEYLL-ATSLDQTTRLF 412 + + WSP +L + S D T R++ Sbjct: 276 GLAIRKVTWSPHHSNILMSASYDMTCRIW 304 Score = 48.4 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 24/129 (18%), Positives = 43/129 (33%), Gaps = 17/129 (13%) Query: 572 LIASACRSNNVQNAVIRIFS-----TENWLEIKPALPFHSLTITRLKFSKD-GKFLLSVC 625 ++A+ N ++ IR+ + N I H L I ++ +S L+S Sbjct: 237 VVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSAS 296 Query: 626 RDRKWALWERNMEDNTFELRFKNEK-----------PHTRIIWDADWAPLEFGNVFVTAS 674 D +W D E N H+ ++ ADW+ + + Sbjct: 297 YDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTA 356 Query: 675 RDKTVKVWR 683 D + VW Sbjct: 357 WDGNLFVWN 365 Score = 48.4 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 32/240 (13%), Positives = 80/240 (33%), Gaps = 25/240 (10%) Query: 245 EEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQ-LLAATADT 303 E + L++ ++ D A+ H+ + S W+ Q L+++ D Sbjct: 71 NESHENQVLVAQGDGTLRLFDT-TFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDG 129 Query: 304 SLMVWEPDETSGIWVCSLRLGEMSS-----------KGASTATGSSGGFWSCLWFTHERM 352 S+ +W P + + R E++ K + T + F+ Sbjct: 130 SIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQ 189 Query: 353 DFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLL-ATSLDQTTRL 411 + L+ ++ + +Q + + + ++ Y++ +D R+ Sbjct: 190 NLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRI 249 Query: 412 FAPWIYDAS-GRKREIATWHEFSRPQIHGYDMICVETVT-----DTRFVSGGDEKILRSF 465 + + + + G+ + +E P HG + + VT +S + R + Sbjct: 250 WDIRMLNKNPGQLHNSSCINEI--PNAHG---LAIRKVTWSPHHSNILMSASYDMTCRIW 304 Score = 43.3 bits (100), Expect = 4e-04, Method: Composition-based stats. Identities = 12/80 (15%), Positives = 23/80 (28%), Gaps = 15/80 (18%) Query: 24 HKVKKIVAFGAGKTIALW-DPIEPNNKGVYAT------------LKGHEAEVTCVRFVPD 70 H +++ T +W D K Y T H V + Sbjct: 287 HHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLW 346 Query: 71 SD--FMVSASEDHHVKIWKF 88 ++ S + D ++ +W Sbjct: 347 GKPGYVASTAWDGNLFVWNG 366 Score = 29.9 bits (65), Expect = 4.2, Method: Composition-based stats. Identities = 18/95 (18%), Positives = 39/95 (41%), Gaps = 6/95 (6%) Query: 611 RLKFS-KDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNV 669 L ++ +L D L++ E K H R ++ +W + N Sbjct: 67 DLAWNESHENQVLVAQGDGTLRLFD----TTFKEFPIAIFKEHEREVFSCNWNLVNRQN- 121 Query: 670 FVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAV 704 F+++S D ++K+W ++ + + ++ TK V Sbjct: 122 FLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMV 156 >5CXB-B nrPDB Length = 369 Score = 78.0 bits (190), Expect = 1e-14, Method: Composition-based stats. Identities = 57/359 (15%), Positives = 113/359 (31%), Gaps = 53/359 (14%) Query: 55 LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP 114 +GHE V V P + + +D V++W+ + ++ + + + P Sbjct: 17 FRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNG--DEAVNTVRWRP 74 Query: 115 S-----LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFY------PLCLSLSKVEE 163 + L + D + I A + GF + L K Sbjct: 75 TKDTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNGKQQANLPPGKEPP 134 Query: 164 KKY-------------LLAIGGTNVNVFIASF------ILSDSGIEKCRVVAELEGHEDW 204 K+ L + + +S SG + L H Sbjct: 135 GKWARPGTRLEDEGVLLRITVRSTIKAISWHRRGDHFATVSPSGQRSSVAIHTLSKHLTQ 194 Query: 205 V-----KSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLT---LLSN 256 + LA P L +Q R IR + ++ +L+ + +K ++ + Sbjct: 195 IPFRKLNGLAQTASFHPLRPLFFVATQ-RSIRCYDLQKLELVKIVQPGAKWISSFDVHPG 253 Query: 257 KQY-------KFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLA-ATADTSLMVW 308 K + +L + + H + I ++++H+ L L A A+ D SL ++ Sbjct: 254 GDNLVVGSYDKRLLWHDLDLSNRPYKTMRFHTEAIRAVRFHKGGLPLFADASDDGSLQIF 313 Query: 309 EPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMW 367 + + KG + G W H R + ++ G G+ R+W Sbjct: 314 HGKVPNDQLENPTIVPVKMLKGHKVV--NKLGVLDIDW--HPREPWCVSAGADGTARLW 368 Score = 65.7 bits (158), Expect = 7e-11, Method: Composition-based stats. Identities = 44/359 (12%), Positives = 98/359 (27%), Gaps = 53/359 (14%) Query: 100 IQHYSKTIVALSALPSL--ISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLS 157 + + + +++ P+ ++ G DGT+ +W + + G + Sbjct: 17 FRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLN-----GDEAVNTVR 71 Query: 158 LSKVEEKKYLLAIGGTNVNVFIASF--ILSDSGIEKCRVVAELEGH-EDWVKSLAFRHQE 214 ++ L A G ++ + I + + ++ GH + + + Sbjct: 72 WRPTKDTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNGKQQANLPPGK 131 Query: 215 TPGDYLLCSGS--QDR--YIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVG 270 P G+ +D +R+ I T+ + Q L Sbjct: 132 EPPGKWARPGTRLEDEGVLLRITVRSTIKAISWHRRGDHFATVSPSGQRSSVAIHTLSKH 191 Query: 271 INFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETS--------GIWVCSL- 321 + + + +H R AT S+ ++ + W+ S Sbjct: 192 LTQIPF-RKLNGLAQTASFHPLRPLFFVAT-QRSIRCYDLQKLELVKIVQPGAKWISSFD 249 Query: 322 ----------RLGEMSSKGASTATGS--------SGGFWSCLWFTHERMDFFLTNGKTGS 363 + + + F + F GS Sbjct: 250 VHPGGDNLVVGSYDKRLLWHDLDLSNRPYKTMRFHTEAIRAVRFHKGGLPLFADASDDGS 309 Query: 364 WRMWATK------DNIICDQRLGISGATK----DVTDIAWSPSGEYLLATSLDQTTRLF 412 +++ K +N + G V DI W P + ++ D T RL+ Sbjct: 310 LQIFHGKVPNDQLENPTIVPVKMLKGHKVVNKLGVLDIDWHPREPWCVSAGADGTARLW 368 Score = 52.2 bits (123), Expect = 8e-07, Method: Composition-based stats. Identities = 32/222 (14%), Positives = 71/222 (31%), Gaps = 57/222 (25%) Query: 15 NKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFM 74 N Q + H ++ + ++I +D + ++ ++ P D + Sbjct: 201 NGLAQTASFHPLRPLFFVATQRSIRCYDL---QKLELVKIVQPGAKWISSFDVHPGGDNL 257 Query: 75 VSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP---SLISVGCADGTISIWRQ 131 V S D + +W D S+ + +T++ +++ I A+ L + DG++ I+ Sbjct: 258 VVGSYDKRL-LWHDLDLSN-RPYKTMRFHTEAIRAVRFHKGGLPLFADASDDGSLQIFHG 315 Query: 132 NIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEK 191 + ND+ P + + ++ K + +G Sbjct: 316 KVPNDQLE------------NPTIVPVKMLKGHKVVNKLG-------------------- 343 Query: 192 CRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW 233 V + + P + S D RLW Sbjct: 344 -------------VLDIDWH----PREPWCVSAGADGTARLW 368 Score = 48.0 bits (112), Expect = 2e-05, Method: Composition-based stats. Identities = 16/92 (17%), Positives = 29/92 (31%), Gaps = 12/92 (13%) Query: 7 PEAIFIGANKQTQVSDIHKVKK--IVAFGAGKTIALW------DPIEPNNKGVYATLKGH 58 P + + HK ++ ++ D +E LKGH Sbjct: 277 PYKTMRFHTEAIRAVRFHKGGLPLFADASDDGSLQIFHGKVPNDQLENPTIVPVKMLKGH 336 Query: 59 E----AEVTCVRFVPDSDFMVSASEDHHVKIW 86 + V + + P + VSA D ++W Sbjct: 337 KVVNKLGVLDIDWHPREPWCVSAGADGTARLW 368 Score = 39.9 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 11/55 (20%), Positives = 21/55 (38%) Query: 271 INFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGE 325 + + GH+ + S+ + + L D ++ VWE +W L E Sbjct: 11 TVQQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDE 65 Score = 36.0 bits (81), Expect = 0.059, Method: Composition-based stats. Identities = 10/48 (20%), Positives = 17/48 (35%), Gaps = 4/48 (8%) Query: 377 QRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLF----APWIYDAS 420 Q+ G V +A P+G L D T R++ ++ Sbjct: 13 QQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVK 60 Score = 35.6 bits (80), Expect = 0.089, Method: Composition-based stats. Identities = 9/77 (11%), Positives = 23/77 (29%), Gaps = 4/77 (5%) Query: 598 IKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIW 657 + H + + G L + D +WE + ++ ++ + Sbjct: 13 QQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEA----VN 68 Query: 658 DADWAPLEFGNVFVTAS 674 W P + + A+ Sbjct: 69 TVRWRPTKDTFILAAAA 85 Score = 31.0 bits (68), Expect = 2.2, Method: Composition-based stats. Identities = 13/76 (17%), Positives = 23/76 (30%), Gaps = 5/76 (6%) Query: 650 KPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISI 709 + H + P G T D TV+VW V + +AV + Sbjct: 18 RGHEGRVRSVAIDP--TGVALATGGDDGTVRVWEL---LTGRQVWSVKLNGDEAVNTVRW 72 Query: 710 HDSMIREKILISVGLE 725 + + + G + Sbjct: 73 RPTKDTFILAAAAGED 88 >5WYJ-BE nrPDB Length = 939 Score = 77.6 bits (189), Expect = 2e-14, Method: Composition-based stats. Identities = 53/366 (14%), Positives = 122/366 (33%), Gaps = 41/366 (11%) Query: 17 QTQVSDIHKVKKIVAFGAGKTIA--LWDPIEPN--------NKGVYATLKGHEAEVTCVR 66 TQ + ++ IV G ++ ++DP + GH + + Sbjct: 298 VTQATFLNGQPIIVTSGGDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPSYIA 357 Query: 67 FV-PDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQ--------HYSKTIVALSALPSLI 117 F S FM+SAS+D +W F+ Q + Q S P ++ Sbjct: 358 FADSQSHFMLSASKDRS--LWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFPEIV 415 Query: 118 SVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEK---KYLLAIGGTN 174 ++ + I W NI T + ++ ++ G Sbjct: 416 ALAIENARIGEWE-NIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMSQCGNF 474 Query: 175 VNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWR 234 + ++ ++ ++ + + + H+ V ++ + + S D + + Sbjct: 475 GFIGSSNGSITIYNMQSGILRKKYKLHKRAVTGISLDGM----NRKMVSCGLDGIVGFYD 530 Query: 235 IRINDLIDDSEEDSKKLTLL---SNKQYKFQIDDELRVGINFE-----ALIMGHDDWISS 286 + L+ + D+ ++ S+ + +DD V I+ + GH + I++ Sbjct: 531 FNKSTLLGKLKLDAPITAMVYHRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITA 590 Query: 287 LQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGAST----ATGSSGGFW 342 + +++A+ D+++ W+ I + + K + AT G Sbjct: 591 FDFSPEGRWIVSASLDSTIRTWDLPTGGCIDGIIVDNVATNVKFSPNGDLLATTHVTGNG 650 Query: 343 SCLWFT 348 C+W Sbjct: 651 ICIWTN 656 Score = 68.8 bits (166), Expect = 1e-11, Method: Composition-based stats. Identities = 33/154 (21%), Positives = 52/154 (33%), Gaps = 11/154 (7%) Query: 24 HKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHV 83 +I + D + + V L GH +T F P+ ++VSAS D + Sbjct: 553 RSSDLFALALDDLSIVVIDAV---TQRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTI 609 Query: 84 KIWKFTDYSHLQCIQT-IQHYSKTIVALSALPSLISVGCADGT-ISIWRQNIQNDEFGLA 141 + W CI I T V S L++ G I IW +F Sbjct: 610 RTWDLPTGG---CIDGIIVDNVATNVKFSPNGDLLATTHVTGNGICIW---TNRAQFKTV 663 Query: 142 HEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNV 175 TI + F + L + V +L+ + Sbjct: 664 STRTIDESEFARMALPSTSVRGNDSMLSGALESN 697 Score = 57.6 bits (137), Expect = 2e-08, Method: Composition-based stats. Identities = 45/422 (10%), Positives = 128/422 (30%), Gaps = 72/422 (17%) Query: 7 PEAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHE---AEVT 63 P++ + +T S V + +D + V + H VT Sbjct: 247 PQSRISSLSFRTDGSSHLSVG---TSSGD--LIFYDLDRRSRIHVLKNI--HRESYGGVT 299 Query: 64 CVRFVPDSDFMVSASEDHHVK-------IWKFTDYSHLQCIQTIQ---HYSKTIVALSAL 113 F+ +V++ D+ +K + + + +Q + ++ +S+ ++ Sbjct: 300 QATFLNGQPIIVTSGGDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPSYIAFA 359 Query: 114 PS---LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAI 170 S + D S+W +++ D + K + + ++A+ Sbjct: 360 DSQSHFMLSASKDR--SLWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFPEIVAL 417 Query: 171 GGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYI 230 N + + H+D + + + + D ++ Sbjct: 418 AIENARIGEW--------------ENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFV 463 Query: 231 RLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWH 290 + + + +T+ + + + +L H ++ + Sbjct: 464 KSVAMSQCGNFGFIGSSNGSITIYNMQSGILRKKYKL------------HKRAVTGISLD 511 Query: 291 ESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHE 350 ++++ D + ++ ++++ + L + ++ Sbjct: 512 GMNRKMVSCGLDGIVGFYDFNKSTLLGKLKLDAPITAMVYHRSS---------------- 555 Query: 351 RMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTR 410 D F S + + Q + G + +T +SP G ++++ SLD T R Sbjct: 556 --DLFALALDDLSIVVIDAVTQRVVRQ---LWGHSNRITAFDFSPEGRWIVSASLDSTIR 610 Query: 411 LF 412 + Sbjct: 611 TW 612 Score = 51.8 bits (122), Expect = 1e-06, Method: Composition-based stats. Identities = 104/650 (16%), Positives = 211/650 (32%), Gaps = 127/650 (19%) Query: 71 SDFMVSASEDHHVKIWKFTDYSH------LQCIQTIQHYSKTIVALSALPSLI--SVGCA 122 D++ ++++D+ + I+K +D + + IV+L L + + Sbjct: 125 GDYLCASTDDNSIFIYKKSDPQDKYPSEFYTKLTVTEIQGGEIVSLQHLATYLNKLTVVT 184 Query: 123 DGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASF 182 + ++ FT + + V + ++A+G V + Sbjct: 185 KSNVLLFNVRTGK------LVFTSNEFPDQITTAEPAPVLD---IIALGTVTGEVIM--- 232 Query: 183 ILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQ------DRYIRLWRIR 236 + K + + ++ + + SL+FR + + S DR R+ ++ Sbjct: 233 ----FNMRKGKRIRTIKIPQSRISSLSFRTDGSSHLSVGTSSGDLIFYDLDRRSRIHVLK 288 Query: 237 I-----------------NDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMG 279 +I S D+ + + D + + G Sbjct: 289 NIHRESYGGVTQATFLNGQPIIVTSGGDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGG 348 Query: 280 HDDWISSLQWHESRLQ-LLAATADTSLMVWEPDETSGIWVCSLRL---GEMSSKGASTAT 335 H S + + +S+ +L+A+ D SL + + + S RL + G ST Sbjct: 349 HSQPPSYIAFADSQSHFMLSASKDRSLWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIK 408 Query: 336 GSSGGFWSCLWFTHERMDF--FLTNGKTGSW-RMWATKDNIICDQRLGISGATKD--VTD 390 + ++ +T K + R W ++ + T D V Sbjct: 409 SKFPEIVALAIENARIGEWENIITAHKDEKFARTWDMRNKRVGRWTFDT---TDDGFVKS 465 Query: 391 IAWSPSGEYLLATSLDQTTRLFAPWIYDA-SGRKREIATWHEFSRPQIHGYDMICVETVT 449 +A S G + S + + IY+ SG R+ H+ + I M Sbjct: 466 VAMSQCGNFGFIGSSNGSI-----TIYNMQSGILRKKYKLHKRAVTGISLDGM------- 513 Query: 450 DTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDA 509 + + VS G + I+ +D K +L K K + P +A V Sbjct: 514 NRKMVSCGLDGIVGFYDFNKST--LLGKL-------KLDAPITAMV-------------- 550 Query: 510 NEDDEEEEGGNKETPDI----TDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLD 565 + D+ D LS++ + ++ V +L+GH IT D Sbjct: 551 ----------YHRSSDLFALALDDLSIVVIDAVTQRV--------VRQLWGHSNRITAFD 592 Query: 566 ISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVC 625 SP+ + I SA ++ IR + I + T +KFS +G L + Sbjct: 593 FSPEGRWIVSAS-----LDSTIRTWDLPTGGCIDGIIV--DNVATNVKFSPNGDLLATTH 645 Query: 626 -RDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTAS 674 +W + T R +E R+ + + + ++ + Sbjct: 646 VTGNGICIWTNRAQFKTVSTRTIDESEFARMALPSTS--VRGNDSMLSGA 693 Score = 38.3 bits (87), Expect = 0.012, Method: Composition-based stats. Identities = 19/91 (20%), Positives = 34/91 (37%), Gaps = 12/91 (13%) Query: 13 GANKQTQVSDIHKVKKI-VAFGAGKTIALWD-PIEPNNKGVYATLKGHEAEV-TCVRFVP 69 G + + D + V+ TI WD P G+ V T V+F P Sbjct: 583 GHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTGGCIDGIIV------DNVATNVKFSP 636 Query: 70 DSDFMV-SASEDHHVKIWKFTDYSHLQCIQT 99 + D + + + + IW T+ + + + T Sbjct: 637 NGDLLATTHVTGNGICIW--TNRAQFKTVST 665 >5WLC-SG nrPDB Length = 573 Score = 77.6 bits (189), Expect = 2e-14, Method: Composition-based stats. Identities = 63/355 (17%), Positives = 121/355 (34%), Gaps = 49/355 (13%) Query: 99 TIQHYSKTI--VALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCL 156 T + + I VA S + G D + +W + K L L Sbjct: 231 TTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSP----VKVIPTKDRRGEVLSL 286 Query: 157 SLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETP 216 + K ++ Y F + I + + L GH D V+ ++ Sbjct: 287 AFRKNSDQLYASCA----------DFKIRTYSINQFSQLEILYGHHDIVEDIS----ALA 332 Query: 217 GDYLLCSGSQDRYIRLWRI--RINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFE 274 + + G++DR LW+I +E K L + K D E++ E Sbjct: 333 MERCVTVGARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESE 392 Query: 275 ALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTA 334 A + + I + + + + + ++ +W + I+ + G + + Sbjct: 393 APLFFCEGSIDVVSMVDD-FHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDI 451 Query: 335 TGSSGG---------------FWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRL 379 +G + FW + + F++ +GS ++W DN+ + L Sbjct: 452 SGETDEELRKRQLQGKKLLQPFWITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELL 511 Query: 380 G-ISGATKDVTDIAWSPSGEY-------LLATSLDQTTRLFAPWIYDASGRKREI 426 G +SGA VT I SG++ L + + + WI + SG + I Sbjct: 512 GELSGAKGVVTKIQVVESGKHGKEKFRILASIAKEHRL---GRWIANVSGARNGI 563 Score = 74.9 bits (182), Expect = 1e-13, Method: Composition-based stats. Identities = 60/346 (17%), Positives = 112/346 (32%), Gaps = 28/346 (8%) Query: 43 PIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQH 102 I + T +GH E+ V PD ++V+ D + +W S ++ I T + Sbjct: 220 YIPTSKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPT-KD 278 Query: 103 YSKTIVALSAL--PSLISVGCADGTISIWRQN-IQNDEFGLAHEFTIKKGFFYP--LCLS 157 +++L+ + CAD I + N E H ++ C++ Sbjct: 279 RRGEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVT 338 Query: 158 LS---------KVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSL 208 + K+ ++ L GG + ++ ++ + V + E + Sbjct: 339 VGARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFC 398 Query: 209 --AFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDE 266 + D+ +GS + I LW + I L S + D+E Sbjct: 399 EGSIDVVSMVDDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISGETDEE 458 Query: 267 LRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEM 326 LR ++ WI+SL ++ + SL VW+ + + LGE+ Sbjct: 459 LRKRQLQGKKLL-QPFWITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFEL---LGEL 514 Query: 327 SSKGASTATGSSGGFWSCLWFTHERMDF--FLTNGKTGSWRMWATK 370 S A G H + F + K W Sbjct: 515 -----SGAKGVVTKIQVVESGKHGKEKFRILASIAKEHRLGRWIAN 555 Score = 61.8 bits (148), Expect = 1e-09, Method: Composition-based stats. Identities = 42/369 (11%), Positives = 97/369 (26%), Gaps = 51/369 (13%) Query: 133 IQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKC 192 + + F + S + + ++ + +K Sbjct: 152 VGENNLTCISCFQPVLNKYTFEESSNGDKNKGRLFAYTVSKDLQLTKYDITDFSKRPKKL 211 Query: 193 RV---------------VAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRI 237 + EGH D + ++A +P + +G +DR + +W Sbjct: 212 KYAKGGAKYIPTSKHEYENTTEGHYDEILTVA----ASPDGKYVVTGGRDRKLIVWSTES 267 Query: 238 NDLID-----DSEEDSKKLTLLSNKQYKFQIDDELRVGI------NFEALIMGHDDWISS 286 + D + L N + + ++ + ++ GH D + Sbjct: 268 LSPVKVIPTKDRRGEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVED 327 Query: 287 LQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLW 346 + + D + M+W+ + + + + + G + Sbjct: 328 ISALAMERCVTVGARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKY 387 Query: 347 FTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLD 406 F G M + + WS + + + T Sbjct: 388 PDESEAPLFFCEGSIDVVSMVD---------DFHFITGSDNGNICLWSLAKKKPIFTERI 438 Query: 407 QTTRLFAPWIYDASGRKREIATWHEFSRPQIHG------YDMICVETVT-DTRFVSGGDE 459 L P D SG E E + Q+ G + + + + F+SG Sbjct: 439 AHGILPEPSFNDISGETDE-----ELRKRQLQGKKLLQPFWITSLYAIPYSNVFISGSWS 493 Query: 460 KILRSFDLP 468 L+ + + Sbjct: 494 GSLKVWKIS 502 Score = 58.4 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 39/218 (17%), Positives = 74/218 (33%), Gaps = 25/218 (11%) Query: 555 YGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPA-LPFHSLTITRLK 613 GH EI + SPD K + + R + ++STE+ +K + L Sbjct: 233 EGHYDEILTVAASPDGKYVVTGGRDRKLI-----VWSTESLSPVKVIPTKDRRGEVLSLA 287 Query: 614 FSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTA 673 F K+ L + C D K + N L ++ D + L Sbjct: 288 FRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVE-------DISALAMERCVTVG 340 Query: 674 SRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGL---ENGEIY 730 +RD+T +W+ E + + + K + + E Sbjct: 341 ARDRTAMLWKIPDET------RLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAP 394 Query: 731 LYSYTLGKFELITQLNE--DITPADKITRLRWSHLKRN 766 L+ + G ++++ +++ IT +D WS K+ Sbjct: 395 LF-FCEGSIDVVSMVDDFHFITGSDNGNICLWSLAKKK 431 Score = 52.6 bits (124), Expect = 7e-07, Method: Composition-based stats. Identities = 74/421 (17%), Positives = 127/421 (30%), Gaps = 80/421 (19%) Query: 235 IRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRL 294 + D+ D S+ K +Y E +E GH D I ++ Sbjct: 196 LTKYDITDFSKRPKKLKYAKGGAKYIPTSKHE------YENTTEGHYDEILTVAASPDGK 249 Query: 295 QLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGG--FWSCLWFTHERM 352 ++ D L+VW + S + V + + + S A + + SC F Sbjct: 250 YVVTGGRDRKLIVWSTESLSPVKVIPTK--DRRGEVLSLAFRKNSDQLYASCADF----K 303 Query: 353 DFFLTNGKTGSWRMWATKDNIICD------QRLGISGATKDVTDIAWSPSGEYLLATSLD 406 + + + +I+ D +R GA + P L D Sbjct: 304 IRTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGARDRTAMLWKIPDETRLTFRGGD 363 Query: 407 QTTRLFAPWIY-DAS-GRKREIATWHEFSRPQIHGY-DMICVETVTDTRFVSGGDEKILR 463 + +L W+ +A G E+ E P + V V D F++G D + Sbjct: 364 EPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVSMVDDFHFITGSDNGNIC 423 Query: 464 SFDLPKGVAGMLQKFV-GIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKE 522 + L K ++ GI L + D + E DEE Sbjct: 424 LWSLAKKKPIFTERIAHGI------------------LPEPSFNDISGETDEEL------ 459 Query: 523 TPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNV 582 + QLQ L F IT L P + S S ++ Sbjct: 460 ---------------RKRQLQGKKLLQP--------FWITSLYAIPYSNVFISGSWSGSL 496 Query: 583 QNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKF-------LLSVCRDRKWALWER 635 + I E+ L +T+++ + GK L S+ ++ + W Sbjct: 497 KVWKIS--DNLRSFELLGELSGAKGVVTKIQVVESGKHGKEKFRILASIAKEHRLGRWIA 554 Query: 636 N 636 N Sbjct: 555 N 555 Score = 38.0 bits (86), Expect = 0.015, Method: Composition-based stats. Identities = 36/232 (15%), Positives = 75/232 (32%), Gaps = 44/232 (18%) Query: 8 EAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCV-R 66 E ++ + +S + + + +T LW T +G + + R Sbjct: 316 EILYGHHDIVEDISALAMERCVTVGARDRTAMLW----KIPDETRLTFRGGDEPQKLLRR 371 Query: 67 FVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTI 126 ++ ++ ED VK ++ C S +V++ I G +G I Sbjct: 372 WMKEN---AKEGEDGEVKYPDESEAPLFFC-----EGSIDVVSMVDDFHFI-TGSDNGNI 422 Query: 127 SIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSD 186 +W KK + ++ + E + G T+ L Sbjct: 423 CLWSLA--------------KKKPIFTERIAHGILPEPSFNDISGETDE-------ELRK 461 Query: 187 SGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRIN 238 ++ +++ W+ SL P + SGS +++W+I N Sbjct: 462 RQLQGKKLLQPF-----WITSL----YAIPYSNVFISGSWSGSLKVWKISDN 504 >5A31-R nrPDB Length = 386 Score = 76.5 bits (186), Expect = 4e-14, Method: Composition-based stats. Identities = 33/212 (15%), Positives = 73/212 (34%), Gaps = 29/212 (13%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 + + + + T++ H EV +++ + + S D+ V +++ Sbjct: 186 LTSGSRDH--RILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEG 243 Query: 89 TDYSHLQCIQTIQHYSKTIVALSALPS---LISVGCA--DGTISIWRQNIQNDEFGLAHE 143 T I T + + A++ P +++ G D + IW N + Sbjct: 244 T---SKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDI--- 297 Query: 144 FTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHED 203 +C + + + + G + N+ + D +A L+GH Sbjct: 298 -----DSGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDP-------IAILKGHSF 345 Query: 204 WVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI 235 V L + T + SG+ D +R W++ Sbjct: 346 RVLHLTLSNDGTT----VVSGAGDETLRYWKL 373 Score = 76.5 bits (186), Expect = 4e-14, Method: Composition-based stats. Identities = 44/262 (16%), Positives = 94/262 (35%), Gaps = 33/262 (12%) Query: 59 EAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLIS 118 E E T + ++ + + V+I+ +CI+T+ + + LS +++ Sbjct: 131 ENEYTSLSWIGAGSHLAVGQANGLVEIYDVM---KRKCIRTLSGHIDRVACLSWNNHVLT 187 Query: 119 VGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVF 178 G D I + + F TI+ L + + K LA GG + V Sbjct: 188 SGSRDHRILHRDVRMPDPFFE-----TIESHTQEVCGLKWNVADNK---LASGGNDNVVH 239 Query: 179 IASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRIN 238 + + + H+ VK++A+ + G G+ DR +++W + + Sbjct: 240 VYEGTSKSP-------ILTFDEHKAAVKAMAWSPHK-RGVLATGGGTADRRLKIWNVNTS 291 Query: 239 DLIDDSEEDS------------KKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISS 286 + D + S + +T +Y + D + + A++ GH + Sbjct: 292 IKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSM--DPIAILKGHSFRVLH 349 Query: 287 LQWHESRLQLLAATADTSLMVW 308 L +++ D +L W Sbjct: 350 LTLSNDGTTVVSGAGDETLRYW 371 Score = 65.7 bits (158), Expect = 8e-11, Method: Composition-based stats. Identities = 45/281 (16%), Positives = 104/281 (37%), Gaps = 40/281 (14%) Query: 153 PLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRH 212 + L ++ E G+++ V A+ ++ + K + + L GH D V L++ + Sbjct: 124 VVHLCDTENEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWNN 183 Query: 213 QETPGDYLLCSGSQDRYIRLWRIRI----NDLIDDSEEDSKKLTL-LSNKQYKFQIDDEL 267 ++L SGS+D I +R+ + I+ ++ L +++ + +D + Sbjct: 184 ------HVLTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNV 237 Query: 268 -----RVGINFEALIMGHDDWISSLQWHESRLQLLA---ATADTSLMVWEPDETSGIWVC 319 + H + ++ W + +LA TAD L +W + + + Sbjct: 238 VHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDI 297 Query: 320 SLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRL 379 + + ++ + +H + LT +W D Sbjct: 298 DSGSQICNMVWSK----NTNELVT----SHGYSKYNLT--------LWDCNS---MDPIA 338 Query: 380 GISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDAS 420 + G + V + S G +++ + D+T R + ++D S Sbjct: 339 ILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWK--LFDVS 377 Score = 48.4 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 26/183 (14%), Positives = 60/183 (32%), Gaps = 20/183 (10%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 + L GH + CL + ++ S R + + + +R+ + H+ + Sbjct: 166 IRTLSGHIDRVACLSW--NNHVLTSGSRDHRILHRDVRMPDPF-----FETIESHTQEVC 218 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAP-LEFGNV 669 LK++ L S D ++E + H + W+P Sbjct: 219 GLKWNVADNKLASGGNDNVVHVYEGTSKSPILTF-----DEHKAAVKAMAWSPHKRGVLA 273 Query: 670 FVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEI 729 + D+ +K+W + + + I + + S +++ S G + Sbjct: 274 TGGGTADRRLKIWNV-----NTSIKMSDIDSGSQICNMVW--SKNTNELVTSHGYSKYNL 326 Query: 730 YLY 732 L+ Sbjct: 327 TLW 329 Score = 45.7 bits (106), Expect = 8e-05, Method: Composition-based stats. Identities = 19/82 (23%), Positives = 31/82 (37%), Gaps = 5/82 (6%) Query: 13 GANKQTQVSDIHKVKKIVAFGAGK--TIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPD 70 ++ + ++V + LWD N+ A LKGH V + D Sbjct: 299 SGSQICNMVWSKNTNELVTSHGYSKYNLTLWDC---NSMDPIAILKGHSFRVLHLTLSND 355 Query: 71 SDFMVSASEDHHVKIWKFTDYS 92 +VS + D ++ WK D S Sbjct: 356 GTTVVSGAGDETLRYWKLFDVS 377 Score = 33.3 bits (74), Expect = 0.43, Method: Composition-based stats. Identities = 11/41 (26%), Positives = 17/41 (41%) Query: 594 NWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWE 634 N ++ L HS + L S DG ++S D W+ Sbjct: 332 NSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWK 372 >4OWR-A nrPDB Length = 339 Score = 76.1 bits (185), Expect = 6e-14, Method: Composition-based stats. Identities = 43/323 (13%), Positives = 95/323 (29%), Gaps = 48/323 (14%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 ++A + W+ + + + + + H V V + D + +AS D K+W Sbjct: 28 LIAGSWANDVRCWEV-QDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDL 86 Query: 89 TDYSHLQCIQTIQHYSKTIVAL----SALPSLISVGCADGTISIWRQNIQNDEFGLAHEF 144 + +Q Q + + + + S + G D T+ W N L Sbjct: 87 SSNQAIQIAQ----HDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQL-- 140 Query: 145 TIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDW 204 + Y +A+ T I + L + E R+ + L+ H+ Sbjct: 141 -----------PERCYCADVIYPMAVVATAERGLIV-YQLENQPSEFRRIESPLK-HQHR 187 Query: 205 VKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQID 264 ++ Q P + L S I I + + F+ Sbjct: 188 CVAIFKDKQNKPTGFALGS-----------IEGRVAIHYINPPNPAK-----DNFTFKCH 231 Query: 265 DELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLG 324 + I ++ + +H L +D W+ D + + Sbjct: 232 RSNGTNTSAPQDIYA----VNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSE---- 283 Query: 325 EMSSKGASTATGSSGGFWSCLWF 347 ++ ++ +G ++ Sbjct: 284 QLDQPISACCFNHNGNIFAYASS 306 Score = 65.3 bits (157), Expect = 9e-11, Method: Composition-based stats. Identities = 37/268 (13%), Positives = 72/268 (26%), Gaps = 36/268 (13%) Query: 7 PEAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVR 66 P+A + V K+ KT +WD + H+A V + Sbjct: 50 PKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQIAQ----HDAPVKTIH 105 Query: 67 F--VPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADG 124 + P+ +++ S D +K W + + +Q + + + V A+ Sbjct: 106 WIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPE----RCYCADVIYPMAVVATAER 161 Query: 125 TISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFIL 184 + +++ Q EF + + + K A+G V I Sbjct: 162 GLIVYQLENQPSEFRRIESPLKHQHRCVAI---FKDKQNKPTGFALGSIEGRVAIHYINP 218 Query: 185 SDSGIEKCRVVAELEGHEDW------------VKSLAFRHQETPGDYLLCSGSQDRYIRL 232 + + + H V +AF L + D Sbjct: 219 PNPAKDNF----TFKCHRSNGTNTSAPQDIYAVNGIAFHPVHGT----LATVGSDGRFSF 270 Query: 233 WRIRINDLIDDSE---EDSKKLTLLSNK 257 W + SE + N Sbjct: 271 WDKDARTKLKTSEQLDQPISACCFNHNG 298 Score = 60.7 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 25/139 (17%), Positives = 51/139 (36%), Gaps = 13/139 (9%) Query: 550 EVEKLYGHGFEITCLDISPD---QKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHS 606 ++E I CL SP + + +N+V+ ++ ++ I A H+ Sbjct: 2 DIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQ----DSGQTIPKAQQMHT 57 Query: 607 LTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEF 666 + + +S DG + + D+ +W+ + H + W Sbjct: 58 GPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAI------QIAQHDAPVKTIHWIKAPN 111 Query: 667 GNVFVTASRDKTVKVWRHQ 685 + +T S DKT+K W + Sbjct: 112 YSCVMTGSWDKTLKFWDTR 130 Score = 55.3 bits (131), Expect = 1e-07, Method: Composition-based stats. Identities = 27/134 (20%), Positives = 49/134 (36%), Gaps = 13/134 (9%) Query: 335 TGSSGGFWSCLWFTHERMD--FFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIA 392 T S CL F+ + F + R W +D+ + T V D+ Sbjct: 6 TSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQM-HTGPVLDVC 64 Query: 393 WSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTR 452 WS G + S D+T ++ +D S + H+ IH ++ + Sbjct: 65 WSDDGSKVFTASCDKTAKM-----WDLSSNQAIQIAQHDAPVKTIH--W---IKAPNYSC 114 Query: 453 FVSGGDEKILRSFD 466 ++G +K L+ +D Sbjct: 115 VMTGSWDKTLKFWD 128 Score = 52.6 bits (124), Expect = 7e-07, Method: Composition-based stats. Identities = 23/169 (13%), Positives = 51/169 (30%), Gaps = 48/169 (28%) Query: 202 EDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKF 261 +D + L+F PG++L+ GS +R W ++ + Sbjct: 10 DDSIGCLSFSPPTLPGNFLIA-GSWANDVRCWEVQDSGQ--------------------- 47 Query: 262 QIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSL 321 +A M H + + W + ++ A+ D + +W+ I + Sbjct: 48 ---------TIPKAQQM-HTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQIAQH 97 Query: 322 RLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATK 370 + +SC+ +T + + W T+ Sbjct: 98 DAPVKTIHWIKAPN------YSCV----------MTGSWDKTLKFWDTR 130 Score = 52.2 bits (123), Expect = 8e-07, Method: Composition-based stats. Identities = 34/149 (22%), Positives = 53/149 (35%), Gaps = 15/149 (10%) Query: 608 TITRLKFSKD---GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPL 664 +I L FS G FL++ WE T K ++ HT + D W+ Sbjct: 12 SIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIP---KAQQMHTGPVLDVCWS-- 66 Query: 665 EFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGL 724 + G+ TAS DKT K+W A +H V I + ++ G Sbjct: 67 DDGSKVFTASCDKTAKMWDLSSNQAIQ-----IAQHDAPVKTIHWIKAPNYSCVMT--GS 119 Query: 725 ENGEIYLYSYTLGKFELITQLNEDITPAD 753 + + + ++ QL E AD Sbjct: 120 WDKTLKFWDTRSSNPMMVLQLPERCYCAD 148 >4BH6-A nrPDB Length = 308 Score = 75.3 bits (183), Expect = 1e-13, Method: Composition-based stats. Identities = 33/212 (15%), Positives = 73/212 (34%), Gaps = 29/212 (13%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 88 + + + + T++ H EV +++ + + S D+ V +++ Sbjct: 117 LTSGSRDH--RILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEG 174 Query: 89 TDYSHLQCIQTIQHYSKTIVALSALPS---LISVGCA--DGTISIWRQNIQNDEFGLAHE 143 T I T + + A++ P +++ G D + IW N + Sbjct: 175 T---SKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDI--- 228 Query: 144 FTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHED 203 +C + + + + G + N+ + D +A L+GH Sbjct: 229 -----DSGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDP-------IAILKGHSF 276 Query: 204 WVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI 235 V L + T + SG+ D +R W++ Sbjct: 277 RVLHLTLSNDGTT----VVSGAGDETLRYWKL 304 Score = 74.9 bits (182), Expect = 1e-13, Method: Composition-based stats. Identities = 44/262 (16%), Positives = 94/262 (35%), Gaps = 33/262 (12%) Query: 59 EAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLIS 118 E E T + ++ + + V+I+ +CI+T+ + + LS +++ Sbjct: 62 ENEYTSLSWIGAGSHLAVGQANGLVEIYDVM---KRKCIRTLSGHIDRVACLSWNNHVLT 118 Query: 119 VGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVF 178 G D I + + F TI+ L + + K LA GG + V Sbjct: 119 SGSRDHRILHRDVRMPDPFFE-----TIESHTQEVCGLKWNVADNK---LASGGNDNVVH 170 Query: 179 IASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRIN 238 + + + H+ VK++A+ + G G+ DR +++W + + Sbjct: 171 VYEGTSKSP-------ILTFDEHKAAVKAMAWSPHK-RGVLATGGGTADRRLKIWNVNTS 222 Query: 239 DLIDDSEEDS------------KKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISS 286 + D + S + +T +Y + D + + A++ GH + Sbjct: 223 IKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSM--DPIAILKGHSFRVLH 280 Query: 287 LQWHESRLQLLAATADTSLMVW 308 L +++ D +L W Sbjct: 281 LTLSNDGTTVVSGAGDETLRYW 302 Score = 64.2 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 43/273 (15%), Positives = 100/273 (36%), Gaps = 38/273 (13%) Query: 153 PLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRH 212 + L ++ E G+++ V A+ ++ + K + + L GH D V L++ + Sbjct: 55 VVHLCDTENEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWNN 114 Query: 213 QETPGDYLLCSGSQDRYIRLWRIRI----NDLIDDSEEDSKKLTL-LSNKQYKFQIDDEL 267 ++L SGS+D I +R+ + I+ ++ L +++ + +D + Sbjct: 115 ------HVLTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNV 168 Query: 268 -----RVGINFEALIMGHDDWISSLQWHESRLQLLA---ATADTSLMVWEPDETSGIWVC 319 + H + ++ W + +LA TAD L +W + + + Sbjct: 169 VHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDI 228 Query: 320 SLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRL 379 + + ++ + +H + LT +W D Sbjct: 229 DSGSQICNMVWSK----NTNELVT----SHGYSKYNLT--------LWDCNS---MDPIA 269 Query: 380 GISGATKDVTDIAWSPSGEYLLATSLDQTTRLF 412 + G + V + S G +++ + D+T R + Sbjct: 270 ILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYW 302 Score = 47.2 bits (110), Expect = 3e-05, Method: Composition-based stats. Identities = 26/183 (14%), Positives = 60/183 (32%), Gaps = 20/183 (10%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 610 + L GH + CL + ++ S R + + + +R+ + H+ + Sbjct: 97 IRTLSGHIDRVACLSW--NNHVLTSGSRDHRILHRDVRMPDPF-----FETIESHTQEVC 149 Query: 611 RLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAP-LEFGNV 669 LK++ L S D ++E + H + W+P Sbjct: 150 GLKWNVADNKLASGGNDNVVHVYEGTSKSPILTF-----DEHKAAVKAMAWSPHKRGVLA 204 Query: 670 FVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEI 729 + D+ +K+W + + + I + + S +++ S G + Sbjct: 205 TGGGTADRRLKIWNV-----NTSIKMSDIDSGSQICNMVW--SKNTNELVTSHGYSKYNL 257 Query: 730 YLY 732 L+ Sbjct: 258 TLW 260 Score = 44.9 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 18/82 (21%), Positives = 30/82 (36%), Gaps = 5/82 (6%) Query: 13 GANKQTQVSDIHKVKKIVAFGAGK--TIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPD 70 ++ + ++V + LWD N+ A LKGH V + D Sbjct: 230 SGSQICNMVWSKNTNELVTSHGYSKYNLTLWDC---NSMDPIAILKGHSFRVLHLTLSND 286 Query: 71 SDFMVSASEDHHVKIWKFTDYS 92 +VS + D ++ WK D Sbjct: 287 GTTVVSGAGDETLRYWKLFDKP 308 Score = 32.9 bits (73), Expect = 0.54, Method: Composition-based stats. Identities = 11/41 (26%), Positives = 17/41 (41%) Query: 594 NWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWE 634 N ++ L HS + L S DG ++S D W+ Sbjct: 263 NSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWK 303 >5MWJ-A nrPDB Length = 337 Score = 74.9 bits (182), Expect = 1e-13, Method: Composition-based stats. Identities = 46/309 (14%), Positives = 89/309 (28%), Gaps = 33/309 (10%) Query: 12 IGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLK--GHEAEVTCVRFVP 69 + + I + V G + +WD P NK + L + + + +P Sbjct: 48 LNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLP 107 Query: 70 DSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS--LISVGCADGTIS 127 D ++ E + IW + + + AL+ P + C+DG I+ Sbjct: 108 DGCTLIVGGEASTLSIWDLA-APTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIA 166 Query: 128 IWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDS 187 +W L +F C+ +S K + GG + V Sbjct: 167 VWDL----HNQTLVRQFQGH--TDGASCIDISNDGTKLW---TGGLDNTVRSW------- 210 Query: 188 GIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLID--DSE 245 + + R + + S F P L G + + + + D E Sbjct: 211 DLREGRQLQ-----QHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHE 265 Query: 246 EDSKKLTLLSNKQY--KFQIDDELRVGINFEALIMGHDDWISSL---QWHESRLQLLAAT 300 L ++ D+ L + SS+ ++ + Sbjct: 266 SCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGS 325 Query: 301 ADTSLMVWE 309 D V+E Sbjct: 326 GDKKATVYE 334 Score = 74.6 bits (181), Expect = 1e-13, Method: Composition-based stats. Identities = 41/302 (13%), Positives = 85/302 (28%), Gaps = 48/302 (15%) Query: 141 AHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEG 200 H I + +++ +++ G V V+ S + S + + + Sbjct: 40 RHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNR--- 96 Query: 201 HEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI-----RINDLIDDSEEDSKKLTLLS 255 +++++S P L G + + +W + RI + S L + Sbjct: 97 -DNYIRSCKL----LPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISP 151 Query: 256 NKQYKFQIDDELRVGI------NFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWE 309 + + F + + + GH D S + +L D ++ W+ Sbjct: 152 DSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 211 Query: 310 PDETSGIWVCS-----LRLGEMSSKGASTATGSSGGF-------------------WSCL 345 E + LG + S L Sbjct: 212 LREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSL 271 Query: 346 WFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSL 405 F + +F++ GK W T Q + V S +Y++ S Sbjct: 272 KFAYCGK-WFVSTGKDNLLNAWRTPYGASIFQS----KESSSVLSCDISVDDKYIVTGSG 326 Query: 406 DQ 407 D+ Sbjct: 327 DK 328 Score = 68.4 bits (165), Expect = 1e-11, Method: Composition-based stats. Identities = 34/228 (14%), Positives = 69/228 (30%), Gaps = 28/228 (12%) Query: 9 AIFIGANKQTQVSDIHKVKKI-VAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRF 67 A + I K+ + + IA+WD N+ + +GH +C+ Sbjct: 135 AELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLH---NQTLVRQFQGHTDGASCIDI 191 Query: 68 VPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTIS 127 D + + D+ V+ W + LQ ++ ++VG + Sbjct: 192 SNDGTKLWTGGLDNTVRSWDLREGRQLQ-QHDFTSQIFSL-GYCPTGEWLAVGMESSNVE 249 Query: 128 IWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDS 187 + N + HE + LSL K+ ++ G + + S Sbjct: 250 VLHVNKPDKYQLHLHESCV---------LSLKFAYCGKWFVSTG-KDNLLNAWRTPYGAS 299 Query: 188 GIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI 235 + V S D + +GS D+ ++ + Sbjct: 300 IFQSKE--------SSSVLSCDISV----DDKYIVTGSGDKKATVYEV 335 Score = 53.8 bits (127), Expect = 3e-07, Method: Composition-based stats. Identities = 42/294 (14%), Positives = 94/294 (31%), Gaps = 52/294 (17%) Query: 212 HQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDD---ELR 268 P D L+ G ++ + +++ + + + + ++ D Sbjct: 25 PVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGN 84 Query: 269 VGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSS 328 + + D++I S + L+ ++L +W+ L + Sbjct: 85 KSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWD-------------LAAPTP 131 Query: 329 KGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDV 388 + + T S+ ++ ++ F + G+ +W + + Q G T Sbjct: 132 RIKAELTSSAPACYALAISPDSKVCF--SCCSDGNIAVWDLHNQTLVRQ---FQGHTDGA 186 Query: 389 TDIAWSPSGEYLLATSLDQTTRLF-----------------------APWIYDASG-RKR 424 + I S G L LD T R + + A G Sbjct: 187 SCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESS 246 Query: 425 EIATWH--EFSRPQIHGYDMICVETVT----DTRFVSGGDEKILRSFDLPKGVA 472 + H + + Q+H ++ CV ++ FVS G + +L ++ P G + Sbjct: 247 NVEVLHVNKPDKYQLHLHE-SCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGAS 299 Score = 46.8 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 20/126 (15%), Positives = 40/126 (31%), Gaps = 11/126 (8%) Query: 561 ITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKF 620 I + PD + ++ + + + E+ + P L S D K Sbjct: 100 IRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAP----ACYALAISPDSKV 155 Query: 621 LLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVK 680 S C D A+W+ + + + + + + G T D TV+ Sbjct: 156 CFSCCSDGNIAVWDLHNQTLVRQFQGHTDGA-------SCIDISNDGTKLWTGGLDNTVR 208 Query: 681 VWRHQK 686 W ++ Sbjct: 209 SWDLRE 214 Score = 36.0 bits (81), Expect = 0.068, Method: Composition-based stats. Identities = 37/168 (22%), Positives = 56/168 (33%), Gaps = 42/168 (25%) Query: 551 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIR-------------IFS-----T 592 V + GH +C+DIS D + + N V++ +R IFS T Sbjct: 176 VRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPT 235 Query: 593 ENWLE----------------IKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERN 636 WL K L H + LKF+ GK+ +S +D W Sbjct: 236 GEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTP 295 Query: 637 MEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRH 684 + F+ + + I D + VT S DK V+ Sbjct: 296 YGASIFQSKESSSVLSCDISVDDKY--------IVTGSGDKKATVYEV 335 >4G56-B nrPDB Length = 357 Score = 73.4 bits (178), Expect = 3e-13, Method: Composition-based stats. Identities = 40/235 (17%), Positives = 79/235 (33%), Gaps = 21/235 (8%) Query: 13 GANKQTQVSDIH--KVKKIVAFGAGKTIALWDPIEPNNK--GVYATLKGHEAEVTCVRFV 68 G + V+D+ K I+ + LW+ +E + +A + H+ V + Sbjct: 90 GVQTEAGVTDVAWVSEKGILVASDSGAVELWEILEKESLLVNKFAKYE-HDDIVKTLSVF 148 Query: 69 PDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISI 128 D VS +D VK+W + + L+ + A ++ DG I + Sbjct: 149 SDGTQAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILL 208 Query: 129 WRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSG 188 W + + P ++ ++ A G NV + + DS Sbjct: 209 WDTRKPKPATRIDFCAS----DTIPTSVTWHPEKDD--TFACGDETGNVSLVNIKNPDSA 262 Query: 189 IEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDD 243 H + LA+ + +P L S S+D + + +++ D Sbjct: 263 QTSAV-------HSQNITGLAYSYHSSP---FLASISEDCTVAVLDADFSEVFRD 307 Score = 46.8 bits (109), Expect = 4e-05, Method: Composition-based stats. Identities = 30/188 (15%), Positives = 62/188 (32%), Gaps = 29/188 (15%) Query: 211 RHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVG 270 + P + L +G ++ + D S+K L+++ ++ + L Sbjct: 77 DPEGAPNESLCTAG----------VQTEAGVTDVAWVSEKGILVASDSGAVELWEILEKE 126 Query: 271 INFEALI--MGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSS 328 HDD + +L Q ++ D S+ VW+ +S Sbjct: 127 SLLVNKFAKYEHDDIVKTLSVFSDGTQAVSGGKDFSVKVWD----------------LSQ 170 Query: 329 KGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDV 388 K + + +C+ + FL+ G+ G +W T+ R+ + Sbjct: 171 KAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTRKPKPAT-RIDFCASDTIP 229 Query: 389 TDIAWSPS 396 T + W P Sbjct: 230 TSVTWHPE 237 Score = 41.0 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 25/160 (15%), Positives = 51/160 (31%), Gaps = 18/160 (11%) Query: 313 TSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWAT-KD 371 IWV G + + + G W + + L +G+ +W + Sbjct: 69 GGSIWVFKDPEGAPNESLCTAGVQTEAGVTDVAWVSEKG---ILVASDSGAVELWEILEK 125 Query: 372 NIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHE 431 + + V ++ G ++ D F+ ++D S + Sbjct: 126 ESLLVNKFAKYEHDDIVKTLSVFSDGTQAVSGGKD-----FSVKVWDLSQKA-------V 173 Query: 432 FSRPQIHGYDMICVETV--TDTRFVSGGDEKILRSFDLPK 469 H ++ CV DT F+S G++ + +D K Sbjct: 174 LKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTRK 213 Score = 39.9 bits (91), Expect = 0.005, Method: Composition-based stats. Identities = 24/118 (20%), Positives = 44/118 (37%), Gaps = 8/118 (6%) Query: 569 DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDR 628 +K I A S V+ I E+ L K A H + L DG +S +D Sbjct: 104 SEKGILVASDSGAVELW--EILEKESLLVNKFAKYEHDDIVKTLSVFSDGTQAVSGGKDF 161 Query: 629 KWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQK 686 +W+ + + K+ H+ + P + +F++ D + +W +K Sbjct: 162 SVKVWDLSQ-----KAVLKSYNAHSSEVNCVAACPGKDT-IFLSCGEDGRILLWDTRK 213 Score = 32.9 bits (73), Expect = 0.60, Method: Composition-based stats. Identities = 16/90 (17%), Positives = 29/90 (32%), Gaps = 9/90 (10%) Query: 1 MVECITPEAIFIGANKQTQVSDI----HKVKKIVAFGAGKTIALWDPIEPNNKGVYATLK 56 +V P++ A ++ + H + + T+A+ D + Sbjct: 253 LVNIKNPDSAQTSAVHSQNITGLAYSYHSSPFLASISEDCTVAVLDADFSEVFRDLS--- 309 Query: 57 GHEAEVTCVRFVP-DSDFMVSASEDHHVKI 85 H VT V + P D + DH V Sbjct: 310 -HRDFVTGVAWSPLDHSKFTTVGWDHKVLH 338 >5N4A-A nrPDB Length = 771 Score = 73.4 bits (178), Expect = 4e-13, Method: Composition-based stats. Identities = 41/288 (14%), Positives = 92/288 (31%), Gaps = 48/288 (16%) Query: 27 KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVP---------DSDFMVSA 77 ++ +TI W+ + + +TL +A T + + P +D A Sbjct: 26 NELFTCSDDQTIHKWNMLGEPEQK-VSTL---DAYFTDMHWYPVSSKKTQAGGTDVFAVA 81 Query: 78 SEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSA--LPSLISVGCADGTISIWRQNIQN 135 D VKI T ++I+ + ++L + ++ DG++ IW +N Sbjct: 82 CTDGSVKILSRTGRVE----KSIEGHKGACISLRWSYDGTALATAGEDGSVKIWSRNGML 137 Query: 136 DEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVV 195 + + + C L ++ +N Sbjct: 138 RSTLAQADSPVYSIVWAYDCDQLCYCTGSNVVIKSLSSNAKQNAW--------------- 182 Query: 196 AELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDD--SEEDSKKLTL 253 + H+ V + + P ++L+ +G +D ++W L + + Sbjct: 183 ---KAHDGVVLKVDWS----PINHLIITGGEDCKYKVWDSFGRLLFQSGLFDYPVTSVAW 235 Query: 254 LSNKQ-YKFQIDDEL----RVGINFEALIMGHDDWISSLQWHESRLQL 296 + + + + L R+G + + + I +L W QL Sbjct: 236 APSGELFAVGGFNTLQLCDRMGWAYSKIHLNDTGSIMTLSWTADSTQL 283 Score = 70.3 bits (170), Expect = 3e-12, Method: Composition-based stats. Identities = 35/239 (14%), Positives = 73/239 (30%), Gaps = 25/239 (10%) Query: 117 ISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVN 176 + D TI W + ++ + +YP+ S + A+ T+ + Sbjct: 28 LFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPV-SSKKTQAGGTDVFAVACTDGS 86 Query: 177 VFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW--R 234 V I S RV +EGH+ SL + + L + +D +++W Sbjct: 87 VKILS--------RTGRVEKSIEGHKGACISLRWSY----DGTALATAGEDGSVKIWSRN 134 Query: 235 IRINDLIDDSEEDSKKLTLLSNKQ---YKFQIDDELR--VGINFEALIMGHDDWISSLQW 289 + + ++ + + Y + ++ + HD + + W Sbjct: 135 GMLRSTLAQADSPVYSIVWAYDCDQLCYCTGSNVVIKSLSSNAKQNAWKAHDGVVLKVDW 194 Query: 290 HESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFT 348 ++ D VW+ + G S A SG ++ F Sbjct: 195 SPINHLIITGGEDCKYKVWDSFGR-----LLFQSGLFDYPVTSVAWAPSGELFAVGGFN 248 Score = 59.5 bits (142), Expect = 5e-09, Method: Composition-based stats. Identities = 36/225 (16%), Positives = 66/225 (29%), Gaps = 47/225 (20%) Query: 221 LCSGSQDRYIRLWRI------RINDLIDDSEEDSKKLTLLSNKQ----------YKFQID 264 L + S D+ I W + +++ L + Q Sbjct: 28 LFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPVSSKKTQAGGTDVFAVACTDGSV 87 Query: 265 DELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDET----------- 313 L E I GH SL+W L A D S+ +W + Sbjct: 88 KILSRTGRVEKSIEGHKGACISLRWSYDGTALATAGEDGSVKIWSRNGMLRSTLAQADSP 147 Query: 314 --------SGIWVC-----SLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGK 360 +C ++ + +SS A + G + ++ +T G+ Sbjct: 148 VYSIVWAYDCDQLCYCTGSNVVIKSLSSNAKQNAWKAHDGVVLKVDWS-PINHLIITGGE 206 Query: 361 TGSWRMWATKDNIICDQR-LGISGATKDVTDIAWSPSGEYLLATS 404 +++W + ++ VT +AW+PSGE Sbjct: 207 DCKYKVWDSFGRLLFQSGLFDYP-----VTSVAWAPSGELFAVGG 246 Score = 48.4 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 31/208 (14%), Positives = 58/208 (27%), Gaps = 51/208 (24%) Query: 557 HGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSK 616 H + ++ + + ++ + R E +E H L++S Sbjct: 61 HWYPVSSKKTQAGGTDVFAVACTDGSVKILSRTGRVEKSIE------GHKGACISLRWSY 114 Query: 617 DGKFLLSVCRDRKWALWERN---------------------MEDNTFELRFKNE------ 649 DG L + D +W RN D N Sbjct: 115 DGTALATAGEDGSVKIWSRNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGSNVVIKSLS 174 Query: 650 --------KPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHT 701 K H ++ DW+P+ ++ +T D KVW L Sbjct: 175 SNAKQNAWKAHDGVVLKVDWSPIN--HLIITGGEDCKYKVWDSFGRLLFQSGLFD----- 227 Query: 702 KAVTAISIHDSMIREKILISVGLENGEI 729 VT+++ S ++ G ++ Sbjct: 228 YPVTSVAWAPSG---ELFAVGGFNTLQL 252 Score = 37.6 bits (85), Expect = 0.021, Method: Composition-based stats. Identities = 20/136 (14%), Positives = 44/136 (32%), Gaps = 18/136 (13%) Query: 280 HDDWISSLQWHESRLQLLAATADTSLMVWEP--DETSGIWVCSLRLGEMSSKGASTATGS 337 H + +++ W+ +L + D ++ W + + +M S+ Sbjct: 13 HSELTAAVGWNVWN-ELFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPVSSKKTQ 71 Query: 338 SGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSG 397 +GG D F GS ++ + + I G + WS G Sbjct: 72 AGG-----------TDVFAVACTDGSVKILSRTGRVEK----SIEGHKGACISLRWSYDG 116 Query: 398 EYLLATSLDQTTRLFA 413 L D + ++++ Sbjct: 117 TALATAGEDGSVKIWS 132 Score = 33.7 bits (75), Expect = 0.33, Method: Composition-based stats. Identities = 26/151 (17%), Positives = 48/151 (31%), Gaps = 23/151 (15%) Query: 651 PHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADD-YVLEASIKHTKAVTAISI 709 H+ + W N T S D+T+ W EP L+A +S Sbjct: 12 VHSELTAAVGW---NVWNELFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWY-PVSS 67 Query: 710 HDSMIREKILISVGLENGEIYLY-----------SYTLGKFELITQLNED--ITPADKIT 756 + + +V +G + + + L + T + + Sbjct: 68 KKTQAGGTDVFAVACTDGSVKILSRTGRVEKSIEGHKGACISLRWSYDGTALATAGEDGS 127 Query: 757 RLRWSHLKRNGKLFLGVGSSDLSTRIYSLAY 787 WS RNG L + +D + +YS+ + Sbjct: 128 VKIWS---RNGMLRSTLAQAD--SPVYSIVW 153 >5FA5-B nrPDB Length = 367 Score = 72.6 bits (176), Expect = 6e-13, Method: Composition-based stats. Identities = 45/244 (18%), Positives = 79/244 (32%), Gaps = 23/244 (9%) Query: 4 CITPEAIFIGANKQT--QVSDIHKVKK--IVAFGAGKTIALWDPIEPNNKGV--YATLKG 57 C P F A QT V+D+ V + I+ + LW+ E V + + Sbjct: 90 CAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYE- 148 Query: 58 HEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLI 117 H+ V+ V + VS S+D +K+W L + + A S+ Sbjct: 149 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVF 208 Query: 118 SVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNV 177 D I +W A + + P L+ + + ++ G N V Sbjct: 209 LSCSEDNRILLWDTRCPKP----ASQIGCSAPGYLPTSLAWHPQQSEVFVF--GDENGTV 262 Query: 178 FIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRI 237 + + + H V L F P L S S+D + + + Sbjct: 263 SLVDTKSTSCVLSSAV-------HSQCVTGLVFSPHSVP---FLASLSEDCSLAVLDSSL 312 Query: 238 NDLI 241 ++L Sbjct: 313 SELF 316 Score = 43.7 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 38/253 (15%), Positives = 76/253 (30%), Gaps = 55/253 (21%) Query: 160 KVEEKKYLLAIGGTNVNVF---IASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETP 216 + LL + + + F + + A ++ V L + Sbjct: 61 YRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAG-VADLTWV----- 114 Query: 217 GDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEAL 276 G+ + S + LW + N+ L + +Y+ Sbjct: 115 GERGILVASDSGAVELWELDENET----------LIVSKFCKYE---------------- 148 Query: 277 IMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATG 336 HDD +S++ S Q ++ + D + VW D + + S R Sbjct: 149 ---HDDIVSTVSVLSSGTQAVSGSKDICIKVW--DLAQQVVLSSYRA------------- 190 Query: 337 SSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPS 396 +C+ + + FL+ + +W T+ Q +G S T +AW P Sbjct: 191 -HAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQ-IGCSAPGYLPTSLAWHPQ 248 Query: 397 GEYLLATSLDQTT 409 + + T Sbjct: 249 QSEVFVFGDENGT 261 Score = 39.9 bits (91), Expect = 0.005, Method: Composition-based stats. Identities = 24/145 (16%), Positives = 51/145 (35%), Gaps = 13/145 (8%) Query: 605 HSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPL 664 H ++ + G +S +D +W+ + R H + +P Sbjct: 149 HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYR-----AHAAQVTCVAASPH 203 Query: 665 EFGNVFVTASRDKTVKVWRHQ-KEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVG 723 + VF++ S D + +W + +PA A T+++ H ++ + G Sbjct: 204 KDS-VFLSCSEDNRILLWDTRCPKPASQIGCSAP---GYLPTSLAWHP---QQSEVFVFG 256 Query: 724 LENGEIYLYSYTLGKFELITQLNED 748 ENG + L L + ++ Sbjct: 257 DENGTVSLVDTKSTSCVLSSAVHSQ 281 Score = 36.8 bits (83), Expect = 0.038, Method: Composition-based stats. Identities = 27/189 (14%), Positives = 62/189 (32%), Gaps = 23/189 (12%) Query: 281 DDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGG 340 + + + ++ LL A++ S W +W+ + S + G Sbjct: 53 ERQLEAARYRSDGALLLGASS-LSGRCW----AGSLWLFKDPCAAPNEGFCSAGVQTEAG 107 Query: 341 FWSCLWFTHERMDFFLTNGKTGSWRMWATKDN-IICDQRLGISGATKDVTDIAWSPSGEY 399 W L +G+ +W +N + + V+ ++ SG Sbjct: 108 VADLTWVGERG---ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQ 164 Query: 400 LLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETV--TDTRFVSGG 457 ++ S D +++ ++A S + H + CV D+ F+S Sbjct: 165 AVSGSKDICIKVW------------DLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCS 212 Query: 458 DEKILRSFD 466 ++ + +D Sbjct: 213 EDNRILLWD 221 Score = 31.8 bits (70), Expect = 1.2, Method: Composition-based stats. Identities = 26/148 (17%), Positives = 47/148 (31%), Gaps = 13/148 (8%) Query: 569 DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKF-----LLS 623 + S + + ++ P F S + D + +L Sbjct: 63 SDGALLLGASSLSGRCWAGSLWL-FKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILV 121 Query: 624 VCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWR 683 LWE + + +F + H I+ + + L G V+ S+D +KVW Sbjct: 122 ASDSGAVELWELDENETLIVSKFCKYE-HDDIV--STVSVLSSGTQAVSGSKDICIKVWD 178 Query: 684 HQKEPADDYVLEASIKHTKAVTAISIHD 711 A VL + H VT ++ Sbjct: 179 L----AQQVVLSSYRAHAAQVTCVAASP 202 >4PSX-B nrPDB Length = 401 Score = 71.5 bits (173), Expect = 1e-12, Method: Composition-based stats. Identities = 47/275 (17%), Positives = 90/275 (32%), Gaps = 49/275 (17%) Query: 46 PNNKGVYATLKGHEAEVTCVRFVP-DSDFMVSASEDHHVKIWKFTDYSHLQCI--QTIQH 102 ++G+ +TLK H+ + F ++S S+DH V +W+ Sbjct: 147 SRSEGLQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDL 206 Query: 103 YSKTIVALSALP---SLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLS 159 +S I L D + I A+ TI +L+ Sbjct: 207 HSDIINDNKWHNFNKDLFGTVSEDSLLKI--------NDVRANNTTIDTVKCPQPFNTLA 258 Query: 160 KVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDY 219 LLA G + V++ + + GHED V +L F D Sbjct: 259 FSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHH------MSGHEDAVNNLEFSTHV---DG 309 Query: 220 LLCSGSQDRYIRLWRIR---INDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEAL 276 ++ S D + +W ++ DD+E+ +L ++ Sbjct: 310 VVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVH--------------------- 348 Query: 277 IMGHDDWISSLQWHESRLQLLAATADTSLM-VWEP 310 GH ++ + L+A+ + +++ VW+ Sbjct: 349 -AGHRSSVNDFDLNPQIPWLVASAEEENILQVWKC 382 Score = 41.0 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 18/95 (18%), Positives = 33/95 (34%), Gaps = 14/95 (14%) Query: 7 PEAIFIGANKQTQVSD--IHKVKKIVAFGAGKTIALWDP-----------IEPNNKGVYA 53 P G + H +V+ G+ + +WD E + Sbjct: 287 PLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIM 346 Query: 54 TLKGHEAEVTCVRFVPDSDFMV-SASEDHHVKIWK 87 GH + V P ++V SA E++ +++WK Sbjct: 347 VHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWK 381 >2AQ5-A nrPDB Length = 402 Score = 71.5 bits (173), Expect = 1e-12, Method: Composition-based stats. Identities = 21/112 (18%), Positives = 44/112 (39%), Gaps = 8/112 (7%) Query: 24 HKVKKIVAFGAGKTIALWDPIEPNN----KGVYATLKGHEAEVTCVRFVPD-SDFMVSAS 78 H I + T+ +W+ + + TL+GH V V + P + ++SA Sbjct: 92 HNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAG 151 Query: 79 EDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSA--LPSLISVGCADGTISI 128 D+ + +W + + + + TI ++ +LI C D + + Sbjct: 152 CDNVILVWDVGTGAAVLTL-GPDVHPDTIYSVDWSRDGALICTSCRDKRVRV 202 Score = 71.1 bits (172), Expect = 2e-12, Method: Composition-based stats. Identities = 28/191 (14%), Positives = 58/191 (30%), Gaps = 21/191 (10%) Query: 57 GHEAEVTCVRFVPDSD-FMVSASEDHHVKIWKFTDY----SHLQCIQTIQHYSKTIVALS 111 GH A V + + P +D + S SED V +W+ D + + T++ ++K + ++ Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVA 138 Query: 112 ALP---SLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLL 168 P +++ D I +W L + S+ + + Sbjct: 139 WHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHP------DTIYSVDWSRDGALIC 192 Query: 169 AIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDR 228 I + + H +V S +R Sbjct: 193 TSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAVFVSEGKILTTG-------FSRMSER 245 Query: 229 YIRLWRIRIND 239 + LW + + Sbjct: 246 QVALWDTKHLE 256 Score = 65.7 bits (158), Expect = 8e-11, Method: Composition-based stats. Identities = 32/169 (18%), Positives = 59/169 (34%), Gaps = 15/169 (8%) Query: 276 LIMGHDDWISSLQWHESRLQLL-AATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTA 334 L+ GH + + W ++ + + D ++MVWE G V LR ++ +G + Sbjct: 76 LVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEI--PDGGLVLPLREPVITLEGHTKR 133 Query: 335 TGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWS 394 G + + + L+ G +W LG + + WS Sbjct: 134 VG-------IVAWHPTAQNVLLSAGCDNVILVWDVGTGAAV-LTLGPDVHPDTIYSVDWS 185 Query: 395 PSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMI 443 G + + D+ R+ P K HE +RP +H + Sbjct: 186 RDGALICTSCRDKRVRVIEPRKGTVVAEKDRP---HEGTRP-VHAVFVS 230 Score = 56.1 bits (133), Expect = 6e-08, Method: Composition-based stats. Identities = 40/279 (14%), Positives = 70/279 (25%), Gaps = 50/279 (17%) Query: 136 DEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVV 195 + G + L ++ ++A G + V + + V Sbjct: 65 GKTGRVDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPV 124 Query: 196 AELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLS 255 LEGH V +A+ +L S D I +W + + D Sbjct: 125 ITLEGHTKRVGIVAWHPTAQN---VLLSAGCDNVILVWDVGTGAAVLTLGPDV------- 174 Query: 256 NKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSG 315 H D I S+ W + + D + V + G Sbjct: 175 ------------------------HPDTIYSVDWSRDGALICTSCRDKRVRV--IEPRKG 208 Query: 316 IWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIIC 375 V ++ S G + + +W TK ++ Sbjct: 209 TVVAEKDRPHEGTRPVHAVFVSEGKILTTGFSRMSER----------QVALWDTK-HLEE 257 Query: 376 DQRLGISGATKDVTDIAWSPSGE--YLLATSLDQTTRLF 412 L + V + P YL D + R F Sbjct: 258 PLSLQELDTSSGVLLPFFDPDTNIVYLCGKG-DSSIRYF 295 Score = 53.8 bits (127), Expect = 3e-07, Method: Composition-based stats. Identities = 31/144 (21%), Positives = 49/144 (34%), Gaps = 16/144 (11%) Query: 550 EVEKLYGHGFEITCLDISP-DQKLIASACRSNNVQNAVIRIFSTENWL-----EIKPALP 603 V + GH + + P + +IAS V I + L E L Sbjct: 73 NVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEI----PDGGLVLPLREPVITLE 128 Query: 604 FHSLTITRLKFSKDG-KFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWA 662 H+ + + + LLS D +W+ L H I+ DW+ Sbjct: 129 GHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTL---GPDVHPDTIYSVDWS 185 Query: 663 PLEFGNVFVTASRDKTVKVWRHQK 686 G + T+ RDK V+V +K Sbjct: 186 --RDGALICTSCRDKRVRVIEPRK 207 Score = 49.9 bits (117), Expect = 5e-06, Method: Composition-based stats. Identities = 21/178 (11%), Positives = 52/178 (29%), Gaps = 13/178 (7%) Query: 7 PEAIFIGANKQTQVSDIHKVKK--IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTC 64 P G K+ + H + +++ G I +WD H + Sbjct: 123 PVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDV-HPDTIYS 181 Query: 65 VRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCA-- 122 V + D + ++ D V++ + + + ++ + A+ I Sbjct: 182 VDWSRDGALICTSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAVFVSEGKILTTGFSR 241 Query: 123 --DGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVF 178 + +++W + L E G P + + G + ++ Sbjct: 242 MSERQVALWDTKHLEEPLSL-QELDTSSGVLLPF-----FDPDTNIVYLCGKGDSSIR 293 Score = 47.2 bits (110), Expect = 3e-05, Method: Composition-based stats. Identities = 31/140 (22%), Positives = 54/140 (38%), Gaps = 15/140 (10%) Query: 551 VEKLYGHGFEITCLDISP-DQKLIASACRSNNVQNAVIRIFSTENWLEIKPALP-FHSLT 608 V L GH + + P Q ++ SA N VI ++ + P H T Sbjct: 124 VITLEGHTKRVGIVAWHPTAQNVLLSAGCDN-----VILVWDVGTGAAVLTLGPDVHPDT 178 Query: 609 ITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGN 668 I + +S+DG + + CRD++ + E E ++PH + G Sbjct: 179 IYSVDWSRDGALICTSCRDKRVRVIEPRKGTVVAE----KDRPHEG-TRPVHAVFVSEGK 233 Query: 669 VFVTA-SR--DKTVKVWRHQ 685 + T SR ++ V +W + Sbjct: 234 ILTTGFSRMSERQVALWDTK 253 Score = 46.4 bits (108), Expect = 5e-05, Method: Composition-based stats. Identities = 37/122 (30%), Positives = 52/122 (42%), Gaps = 13/122 (10%) Query: 651 PHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASI---KHTKAVTAI 707 HT + D W P NV + S D TV VW + E I HTK V + Sbjct: 79 GHTAPVLDIAWCP-HNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIV 137 Query: 708 SIHDSMIREKILISVGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNG 767 + H + + +L+S G +N I ++ G L L D+ P D I + WS R+G Sbjct: 138 AWHPT--AQNVLLSAGCDN-VILVWDVGTGAAVLT--LGPDVHP-DTIYSVDWS---RDG 188 Query: 768 KL 769 L Sbjct: 189 AL 190 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 17/92 (18%), Positives = 35/92 (38%), Gaps = 6/92 (6%) Query: 383 GATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDM 442 G T V DIAW P + ++A+ + T + +++ + + H + Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVM----VWEIPDGGLVLPLREPVITLEGHTKRV 134 Query: 443 ICV--ETVTDTRFVSGGDEKILRSFDLPKGVA 472 V +S G + ++ +D+ G A Sbjct: 135 GIVAWHPTAQNVLLSAGCDNVILVWDVGTGAA 166 >3ACP-A nrPDB Length = 417 Score = 71.1 bits (172), Expect = 2e-12, Method: Composition-based stats. Identities = 42/318 (13%), Positives = 97/318 (30%), Gaps = 42/318 (13%) Query: 56 KGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSA--L 113 + H +E+T ++F P + ++S+S+D +KIW D S+ +T+ + T+ ++ Sbjct: 133 QAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNP---RTLIGHRATVTDIAIIDR 189 Query: 114 PSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGT 173 + DGTI +W + G L +G Sbjct: 190 GRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGV-------------NSIALFVGTD 236 Query: 174 NVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSL--AFRHQETPGDYLLCSGSQDRYIR 231 I++ ++ + GH V ++ F ++T + S Sbjct: 237 RQLHEISTSKKNNLEFGTYGK-YVIAGHVSGVITVHNVFSKEQTIQLPSKFTCSC----- 290 Query: 232 LWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHE 291 + +D + + + D ++ I+++ + Sbjct: 291 -----NSLTVDGNNANY---IYAGYENGMLAQWDLRSPECPVGEFLINEGTPINNVYFA- 341 Query: 292 SRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWS-CLWFTHE 350 + +++ DTS+ + I + + + + C E Sbjct: 342 AGALFVSSGFDTSIKL------DIISDPESERPAIEFETPTFLVSNDDEVSQFCYVSDDE 395 Query: 351 RMDFFLTNGKTGSWRMWA 368 L GK ++ Sbjct: 396 SNGEVLEVGKNNFCALYN 413 Score = 61.8 bits (148), Expect = 1e-09, Method: Composition-based stats. Identities = 45/284 (15%), Positives = 94/284 (33%), Gaps = 55/284 (19%) Query: 17 QTQVSDIHKVK------KIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPD 70 Q VS+I K+K +++ + +W + +N TL GH A VT + + Sbjct: 133 QAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPR---TLIGHRATVTDIAIIDR 189 Query: 71 SDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALS------------------- 111 ++SAS D +++W+ + + ++ + +++ Sbjct: 190 GRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALFVGTDRQLHEISTSKKNN 249 Query: 112 ----ALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYL 167 + G G I++ + L +FT C SL+ Sbjct: 250 LEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLPSKFTCS-------CNSLTVDGNNANY 302 Query: 168 LAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQD 227 + G N + + + + ++ E + ++ F L S D Sbjct: 303 IYAGYENGMLAQWDLRSPECPVGEF-LINEGT----PINNVYFAA-----GALFVSSGFD 352 Query: 228 RYIRLWRIRINDLIDDSEEDSKKLTLLSNK-----QYKFQIDDE 266 I+L I + + + + T L + Q+ + DDE Sbjct: 353 TSIKL-DIISDPESERPAIEFETPTFLVSNDDEVSQFCYVSDDE 395 Score = 51.8 bits (122), Expect = 1e-06, Method: Composition-based stats. Identities = 22/101 (21%), Positives = 39/101 (38%), Gaps = 7/101 (6%) Query: 555 YGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKF 614 H EIT L P + + S+ + ++I+S ++ + + H T+T + Sbjct: 133 QAHVSEITKLKFFPSGEALISSSQDMQ-----LKIWSVKDGSNPRTLI-GHRATVTDIAI 186 Query: 615 SKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRI 655 G+ +LS D LWE + E PH + Sbjct: 187 IDRGRNVLSASLDGTIRLWECGTGTTIHTFN-RKENPHDGV 226 Score = 47.2 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 33/256 (12%), Positives = 82/256 (32%), Gaps = 33/256 (12%) Query: 6 TPEAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCV 65 P + T ++ I + + +++ TI LW+ + + V + Sbjct: 170 NPRTLIGHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSI 229 Query: 66 R---------------------FVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYS 104 F ++++ + + +S Q IQ ++ Sbjct: 230 ALFVGTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNV--FSKEQTIQLPSKFT 287 Query: 105 KTIVALSALP---SLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKV 161 + +L+ + I G +G ++ W G EF I +G ++ Sbjct: 288 CSCNSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVG---EFLINEGT---PINNVYFA 341 Query: 162 EEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLL 221 ++ + T++ + I S S+ + L ++D V + + +L Sbjct: 342 AGALFVSSGFDTSIKLDIISDPESERPAIEFETPTFLVSNDDEVSQFCYVSDDESNGEVL 401 Query: 222 CSGSQDRYIRLWRIRI 237 G ++ + L+ + Sbjct: 402 EVG-KNNFCALYNLSN 416 Score = 43.3 bits (100), Expect = 4e-04, Method: Composition-based stats. Identities = 35/201 (17%), Positives = 60/201 (29%), Gaps = 29/201 (14%) Query: 279 GHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSS 338 H I+ L++ S L++++ D L +W + S T G Sbjct: 134 AHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSN---------------PRTLIGHR 178 Query: 339 GGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIA-WSPSG 397 R L+ G+ R+W V IA + + Sbjct: 179 ATVTDIAIIDRGRN--VLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALFVGTD 236 Query: 398 EYL--LATSLDQTTRLFAPWIYDASGRKREIATWHE-FSRPQI----HGYDMIC----VE 446 L ++TS Y +G + T H FS+ Q + C V+ Sbjct: 237 RQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLPSKFTCSCNSLTVD 296 Query: 447 TVTDTRFVSGGDEKILRSFDL 467 +G + +L +DL Sbjct: 297 GNNANYIYAGYENGMLAQWDL 317 Score = 40.7 bits (93), Expect = 0.003, Method: Composition-based stats. Identities = 29/115 (25%), Positives = 47/115 (40%), Gaps = 12/115 (10%) Query: 639 DNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASI 698 D+ F L+ + ++ H I G +++S+D +K+W + D I Sbjct: 122 DSNFNLQREIDQAHVSEI--TKLKFFPSGEALISSSQDMQLKIWSVK----DGSNPRTLI 175 Query: 699 KHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKFELITQLNEDITPAD 753 H VT I+I D R + ++S L+ G I L+ G I N P D Sbjct: 176 GHRATVTDIAIID---RGRNVLSASLD-GTIRLWECGTGT--TIHTFNRKENPHD 224 >6E29-D nrPDB Length = 345 Score = 70.7 bits (171), Expect = 3e-12, Method: Composition-based stats. Identities = 49/372 (13%), Positives = 108/372 (29%), Gaps = 58/372 (15%) Query: 9 AIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFV 68 I + T V K + + T+ +WD GV L+GH +T + + Sbjct: 20 TNTIRSGHSTCVRFNRKGDFLASGRVDGTVVIWDL---ETMGVARKLRGHSKNITSLSWS 76 Query: 69 PDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP----SLISVGCADG 124 +++SA + V +W D + ++ + + P + D Sbjct: 77 RCGRYLLSACQGWKVILWDLQDGKRYREVR----FRAPVYGAELHPWNHHQFAAALFEDQ 132 Query: 125 TISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLL-----AIGGTNVNVFI 179 + + + L P E+ K++ G ++ Sbjct: 133 PMLVDITEPVEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGDHLLAGT 192 Query: 180 ASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRIND 239 L+ ++ + + +L T L +QDR IR Sbjct: 193 TKGRLNIIDARTREIIYSEKIASGIITTLRL----TESGRELLVNAQDRIIR-------- 240 Query: 240 LIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAA 299 ++ N D +++ + + + + + + + + + A+ Sbjct: 241 -----------TFIVPNLSAADLDPDTIQLPLEHKFQDVVNRLSWNHVAFSATGEYVAAS 289 Query: 300 TADT-SLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTN 358 T + L +WE S + +G G + + H Sbjct: 290 TYNNHELYIWERGHGSLV---------RMLEGPKEEQG-------VIEW-HPHRALLAAC 332 Query: 359 G-KTGSWRMWAT 369 G +TG +W+ Sbjct: 333 GLETGRINIWSV 344 Score = 51.8 bits (122), Expect = 1e-06, Method: Composition-based stats. Identities = 39/185 (21%), Positives = 63/185 (34%), Gaps = 21/185 (11%) Query: 555 YGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKF 614 GH TC+ + +AS V + L HS IT L + Sbjct: 25 SGHS---TCVRFNRKGDFLASGRVDGTVVIWDLETMGVAR------KLRGHSKNITSLSW 75 Query: 615 SKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTAS 674 S+ G++LLS C+ K LW+ E+RF+ ++ A+ P Sbjct: 76 SRCGRYLLSACQGWKVILWDLQDGKRYREVRFR------APVYGAELHPWNHHQFAAALF 129 Query: 675 RDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSY 734 D+ + V + YVL + K T + D +REK +Y+ Sbjct: 130 EDQPMLV-DITEPVEVRYVLPSVPKRTS-----TETDPALREKQAKEDAKHMTTAIVYTA 183 Query: 735 TLGKF 739 + Sbjct: 184 SGDHL 188 Score = 45.7 bits (106), Expect = 9e-05, Method: Composition-based stats. Identities = 19/86 (22%), Positives = 39/86 (45%), Gaps = 9/86 (10%) Query: 339 GGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGE 398 G +C+ F + DF + G+ +W + + + + G +K++T ++WS G Sbjct: 25 SGHSTCVRFNRKG-DFLASGRVDGTVVIWDLETMGVARK---LRGHSKNITSLSWSRCGR 80 Query: 399 YLLATSLDQTTRLFAPWIYDASGRKR 424 YLL+ + + ++D KR Sbjct: 81 YLLS-----ACQGWKVILWDLQDGKR 101 Score = 32.6 bits (72), Expect = 0.62, Method: Composition-based stats. Identities = 22/144 (15%), Positives = 52/144 (36%), Gaps = 20/144 (13%) Query: 3 ECITPEAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALW-----DPIEPNNKGVYATLKG 57 E I E I G T + ++++ + I + + + + L+ Sbjct: 206 EIIYSEKIASGI--ITTLRLTESGRELLVNAQDRIIRTFIVPNLSAADLDPDTIQLPLEH 263 Query: 58 HEAEVTC------VRFVPDSDFMVSASEDHH-VKIWKFTDYSHLQCIQTIQHYSKTIVAL 110 +V V F +++ +++ ++H + IW+ H ++ ++ + + Sbjct: 264 KFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIWERG---HGSLVRMLEGPKEEQGVI 320 Query: 111 SALPS---LISVGCADGTISIWRQ 131 P L + G G I+IW Sbjct: 321 EWHPHRALLAACGLETGRINIWSV 344 >5WLC-LN nrPDB Length = 776 Score = 63.8 bits (153), Expect = 3e-10, Method: Composition-based stats. Identities = 44/310 (14%), Positives = 101/310 (32%), Gaps = 28/310 (9%) Query: 8 EAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNK--GVYATLKGHEAE---- 61 + I + + K ++ + I +W + + + T+K +A+ Sbjct: 180 DTILMRQEARVLTLAWKKDDFVIGGCSDGRIRIWSAQKNDENMGRLLHTMKVDKAKKEST 239 Query: 62 -VTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALS--ALPSLIS 118 V V ++P +D + S +K W F + Q + + ++ L+ + + Sbjct: 240 LVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQS---FKAHDADVLCLTTDTDNNYVF 296 Query: 119 VGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLS-KVEEKKYLLAIGGTNVNV 177 D I + QN + + + ++ + L GG + Sbjct: 297 SAGVDRKIFQFSQNTNKSQKNNRWVNSSNRLLHGNDIRAICAYQSKGADFLVSGGVEKTL 356 Query: 178 FIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRI 237 I S L+ R + +E + V L+ S S+ +++W + Sbjct: 357 VINS--LTSFSNGNYRKMPTVEPYSKNVLV-------NKEQRLVVSWSE-STVKIWTMGT 406 Query: 238 NDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLL 297 + + + + KLTL + Q + + + L++G +L Sbjct: 407 DSSTEQNYKLVCKLTL-KDDQNI----STCSLSPDGQVLVVGRPSTTKVFHLQPVGNKLK 461 Query: 298 AATADTSLMV 307 D L++ Sbjct: 462 VTKLDNDLLL 471 Score = 44.1 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 52/292 (17%), Positives = 102/292 (34%), Gaps = 62/292 (21%) Query: 204 WVKSLAFRHQE-----TPGDYLLCSGSQDRYIRLWRIRIN---------------DLIDD 243 + SLAF H+ TP D L G + I +W R N + + Sbjct: 45 TITSLAFSHKSNINKLTPSDLRLAIGRSNGNIEIWNPRNNWFQEMVIEGGKDRSIEGLCW 104 Query: 244 SEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADT 303 S + + L L S + +L G+ + I S+ ++S+ +L + Sbjct: 105 SNVNGESLRLFSIGGSTVVTEWDLATGL-PLRNYDCNSGVIWSISINDSQDKLSVGCDNG 163 Query: 304 SLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGS 363 ++++ + G+ + + + W DF + G Sbjct: 164 TVVLIDISGGPGV-----------LEHDTILMRQEARVLTLAWKKD---DFVIGGCSDGR 209 Query: 364 WRMWATKDNIICDQRLGISGATKDV------TDIAWS----PSGEYLLATSLDQTTRLFA 413 R+W+ + N D+ +G T V + + WS P + + + + + + Sbjct: 210 IRIWSAQKN---DENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFW- 265 Query: 414 PWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDT--RFVSGGDEKILR 463 + AT ++ + H D++C+ T TD F +G D KI + Sbjct: 266 ---------DFQFATLNQ--SFKAHDADVLCLTTDTDNNYVFSAGVDRKIFQ 306 Score = 39.1 bits (89), Expect = 0.007, Method: Composition-based stats. Identities = 59/409 (14%), Positives = 131/409 (32%), Gaps = 78/409 (19%) Query: 383 GATKDVTDIAWSPSGEYLLATSLDQTTRLFAPW--------IYDASGRKREIATWHEFSR 434 ++ + +PS L + ++ P I R E W + Sbjct: 52 SHKSNINKL--TPSDLRLAIGRSNGNIEIWNPRNNWFQEMVIEGGKDRSIEGLCWSNVNG 109 Query: 435 PQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKGV--------AGMLQKFVGIQFEEK 486 + R S G ++ +DL G+ +G++ ++K Sbjct: 110 ESL--------------RLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISINDSQDK 155 Query: 487 SEMP-DSATVPVLGLSNKAG--EDD-------------ANEDDEEEEGGNKETPDITDPL 530 + D+ TV ++ +S G E D A + D+ GG + + Sbjct: 156 LSVGCDNGTVVLIDISGGPGVLEHDTILMRQEARVLTLAWKKDDFVIGGCSD-----GRI 210 Query: 531 SLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIF 590 + ++ + R L +V+K + + P IAS + +++ + Sbjct: 211 RIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFWDFQF- 269 Query: 591 STENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEK 650 + + H + L D ++ S DRK + +N + R+ N Sbjct: 270 -----ATLNQSFKAHDADVLCLTTDTDNNYVFSAGVDRKIFQFSQNTNKSQKNNRWVNSS 324 Query: 651 P---HTRIIWDADWAPLEFGNVFVTASRDKTVKV--------WRHQKEPADDYVLEASIK 699 H I + + V+ +KT+ + ++K P + + + Sbjct: 325 NRLLHGNDIRAICAYQSKGADFLVSGGVEKTLVINSLTSFSNGNYRKMPTVEPYSKNVLV 384 Query: 700 HTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKFELITQLNED 748 + + +S +S ++ + ++G ++ Y K L +D Sbjct: 385 NKEQRLVVSWSESTVK---IWTMGTDSSTEQNY-----KLVCKLTLKDD 425 Score = 33.3 bits (74), Expect = 0.40, Method: Composition-based stats. Identities = 28/206 (13%), Positives = 70/206 (33%), Gaps = 18/206 (8%) Query: 552 EKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTEN---WLEIK-PALPFHSL 607 + H ++ CL D + SA + ++ W+ L + + Sbjct: 274 QSFKAHDADVLCLTTDTDNNYVFSAGVDRKIFQFSQNTNKSQKNNRWVNSSNRLLHGNDI 333 Query: 608 TITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFG 667 SK FL+S ++ + N + ++ + + Sbjct: 334 RAICAYQSKGADFLVSGGVEKTLVI---NSLTSFSNGNYRKMPTVEPYSKNV---LVNKE 387 Query: 668 NVFVTASRDKTVKVWRHQKEPADDY----VLEASIKHTKAVTAISIHDSMIREKILISVG 723 V + + TVK+W + + + V + ++K + ++ S+ + ++ VG Sbjct: 388 QRLVVSWSESTVKIWTMGTDSSTEQNYKLVCKLTLKDDQNISTCSLSP----DGQVLVVG 443 Query: 724 LENGEIYLYSYTLGKFELITQLNEDI 749 + + +G +T+L+ D+ Sbjct: 444 RPSTTKVFHLQPVGNKLKVTKLDNDL 469 >2P9P-C nrPDB Length = 372 Score = 63.0 bits (151), Expect = 6e-10, Method: Composition-based stats. Identities = 51/329 (15%), Positives = 99/329 (30%), Gaps = 23/329 (6%) Query: 52 YATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQ-HYSKTIVAL 110 LK H +VT V + PDS+ +V+ D + +W + + ++ + + V Sbjct: 45 VHELKEHNGQVTGVDWAPDSNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRW 104 Query: 111 SALPSLISVGCADGTISIWRQNIQNDEFGLAH-----EFTIKKGFFYPLCLSLSKVE-EK 164 + +VG ISI +ND + H T+ ++P + L+ + Sbjct: 105 APNEKKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDF 164 Query: 165 KYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSG 224 K + + S + ++ E WV + F + Sbjct: 165 KCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFS----ANGSRVAWV 220 Query: 225 SQDRYIRLWRIRIN---DLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHD 281 S D + L + +T ++ D V +++ G Sbjct: 221 SHDSTVCLADADKKMAVATLASETLPLLAVTFITESSLVAAGHDCFPVLFTYDS-AAGKL 279 Query: 282 DWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGF 341 + L + Q + + + + G L + S + SGG Sbjct: 280 SFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGSAAAGAGLDSLHKNSVSQISVLSGGK 339 Query: 342 WSCLWFTHERMDFFLTNGKTGSWRMWATK 370 C F T G G +W + Sbjct: 340 AKCSQF--------CTTGMDGGMSIWDVR 360 Score = 61.5 bits (147), Expect = 1e-09, Method: Composition-based stats. Identities = 37/205 (18%), Positives = 67/205 (32%), Gaps = 6/205 (2%) Query: 16 KQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMV 75 + T V +IV G + +W K L+ + A CVR+ P+ Sbjct: 54 QVTGVDWAPDSNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAA-RCVRWAPNEKKFA 112 Query: 76 SASEDHHVKI-WKFTDYSHLQCIQTIQHYSKTIVALSALPS--LISVGCADGTISIWRQN 132 S + I + + C + T+++L P+ L++ G D I+ Sbjct: 113 VGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAY 172 Query: 133 IQNDEFGLAHEFTIKKGFFYPLCLSLSKVEE--KKYLLAIGGTNVNVFIASFILSDSGIE 190 I+ E A K F L S + G+ V + + + Sbjct: 173 IKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTVCLADAD 232 Query: 191 KCRVVAELEGHEDWVKSLAFRHQET 215 K VA L + ++ F + + Sbjct: 233 KKMAVATLASETLPLLAVTFITESS 257 Score = 43.7 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 20/143 (13%), Positives = 47/143 (32%), Gaps = 14/143 (9%) Query: 280 HDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSG 339 H+ ++ + W +++ D + VW + + +++ Sbjct: 51 HNGQVTGVDWAPDSNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAAR---------- 100 Query: 340 GFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEY 399 C+ + F + +G + ++N + V + W P+ Sbjct: 101 ----CVRWAPNEKKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNSVL 156 Query: 400 LLATSLDQTTRLFAPWIYDASGR 422 L A S D R+F+ +I + R Sbjct: 157 LAAGSCDFKCRIFSAYIKEVEER 179 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 22/152 (14%), Positives = 52/152 (34%), Gaps = 7/152 (4%) Query: 548 WPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSL 607 W +V +L H ++T +D +PD I + N ++ W L + Sbjct: 42 WVQVHELKEHNGQVTGVDWAPDSNRIVTCGTDRNAYVWTLK---GRTWKPTLVILRI-NR 97 Query: 608 TITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFG 667 ++++ + K R ++ E++ + + +KP + DW P Sbjct: 98 AARCVRWAPNEKKFAVGSGSRVISICYFEQENDWWVCK-HIKKPIRSTVLSLDWHP--NS 154 Query: 668 NVFVTASRDKTVKVWRHQKEPADDYVLEASIK 699 + S D +++ + ++ Sbjct: 155 VLLAAGSCDFKCRIFSAYIKEVEERPAPTPWG 186 Score = 36.0 bits (81), Expect = 0.059, Method: Composition-based stats. Identities = 23/182 (12%), Positives = 51/182 (28%), Gaps = 23/182 (12%) Query: 60 AEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSA-LPSLIS 118 V V F + + S D V + D + T+ + ++A++ S + Sbjct: 203 GWVHGVCFSANGSRVAWVSHDSTVCL---ADADKKMAVATLASETLPLLAVTFITESSLV 259 Query: 119 VGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVF 178 D ++ + + LS + + G Sbjct: 260 AAGHDCFPVLFTYDSAAGK------------------LSFGGRLDVPKQSSQRGLTARER 301 Query: 179 IASFILSDSGIEKCRVVAELEG-HEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRI 237 + S A L+ H++ V ++ C+ D + +W +R Sbjct: 302 FQNLDKKASSEGSAAAGAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVRS 361 Query: 238 ND 239 + Sbjct: 362 LE 363 Score = 32.9 bits (73), Expect = 0.54, Method: Composition-based stats. Identities = 11/80 (13%), Positives = 24/80 (30%), Gaps = 7/80 (8%) Query: 343 SCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLA 402 SC + +R ++ N + VT + W+P ++ Sbjct: 12 SCHAWNKDRTQ-IAICPNNHEVHIYEKSGNKWVQVH-ELKEHNGQVTGVDWAPDSNRIVT 69 Query: 403 TSLDQTTRLFAPWIYDASGR 422 D+ +++ GR Sbjct: 70 CGTDR-----NAYVWTLKGR 84 >5A9Q-0 nrPDB Length = 380 Score = 62.2 bits (149), Expect = 9e-10, Method: Composition-based stats. Identities = 19/123 (15%), Positives = 42/123 (34%), Gaps = 3/123 (2%) Query: 38 IALWDP-IEPNNKGVYATLKGHEAEVTCVRFVPDSDFMV-SASEDHHVKIWKFTDYSH-L 94 + +WD + N +L G + CV P+ +V + +D + IW + + Sbjct: 195 LKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPV 254 Query: 95 QCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPL 154 ++ + + + P + DG++ W + E + F Sbjct: 255 SLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQGGRSSTFLSH 314 Query: 155 CLS 157 +S Sbjct: 315 SIS 317 Score = 59.9 bits (143), Expect = 4e-09, Method: Composition-based stats. Identities = 36/309 (11%), Positives = 85/309 (27%), Gaps = 35/309 (11%) Query: 69 PDSDFMVSASEDHH---VKIWKFTD----------YSHLQCIQTIQHYSKTIVALSALPS 115 ++ + S D+ + +W D Q + I+H+ + Sbjct: 27 QTAETFATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCDIRHHGDVMDLQFFDQE 86 Query: 116 LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNV 175 I + G ++++ + N + ++T P S S + + Sbjct: 87 RIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTG--VVCNNPEI 144 Query: 176 NVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI 235 ++ + V + D S + + + +++W Sbjct: 145 VTVGEDGRINLFRADHKEAVRTI----DNADSSTLHAVTFLRTPEILTVNSIGQLKIWDF 200 Query: 236 RIND-------LIDDSEEDSKKLTLLSNKQYKFQIDD--------ELRVGINFEALIMGH 280 R + + N+Q+ ++R G +L+ H Sbjct: 201 RQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAH 260 Query: 281 DDWISSLQWHESRL-QLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSG 339 + + + +H S L + D SL W+ G SS S + + Sbjct: 261 EAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQGGRSSTFLSHSISNQA 320 Query: 340 GFWSCLWFT 348 + + Sbjct: 321 NVHQSVISS 329 Score = 37.2 bits (84), Expect = 0.030, Method: Composition-based stats. Identities = 12/74 (16%), Positives = 28/74 (37%), Gaps = 5/74 (6%) Query: 621 LLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVK 680 + + +D ++W+ + K H +W+ + P ++F T S D ++ Sbjct: 233 VATGGQDGMLSIWDVRQG----TMPVSLLKAHEAEMWEVHFHPSNPEHLF-TCSEDGSLW 287 Query: 681 VWRHQKEPADDYVL 694 W + + L Sbjct: 288 HWDASTDVPEKSSL 301 Score = 36.4 bits (82), Expect = 0.044, Method: Composition-based stats. Identities = 15/111 (13%), Positives = 37/111 (33%), Gaps = 5/111 (4%) Query: 550 EVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTI 609 ++ L G + C+D P+Q+ + + Q+ ++ I+ L H + Sbjct: 209 QILSLTGDRVPLHCVDRHPNQQHVVATG----GQDGMLSIWDVRQGTMPVSLLKAHEAEM 264 Query: 610 TRLKFSKDG-KFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDA 659 + F + L + D W+ + + F + + + Sbjct: 265 WEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQGGRSSTFLSHS 315 Score = 32.2 bits (71), Expect = 0.81, Method: Composition-based stats. Identities = 15/76 (19%), Positives = 30/76 (39%), Gaps = 8/76 (10%) Query: 355 FLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSG-EYLLATSLDQTTRLFA 413 T G+ G +W + + + ++ ++ + PS E+L S D + Sbjct: 233 VATGGQDGMLSIWDVRQGTMPVS--LLKAHEAEMWEVHFHPSNPEHLFTCSEDGSL---- 286 Query: 414 PWIYDASGRKREIATW 429 W +DAS E ++ Sbjct: 287 -WHWDASTDVPEKSSL 301 >6CHG-D nrPDB Length = 439 Score = 59.1 bits (141), Expect = 7e-09, Method: Composition-based stats. Identities = 44/303 (14%), Positives = 90/303 (29%), Gaps = 38/303 (12%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKG-HEAEVTCVRFVPDSDFMVSASEDHHVKIWK 87 + + I ++D + T G H V V + D ++ S+ D + K+W Sbjct: 42 LAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSVQSVCWSNDGRYLWSSGRDWYAKLWD 101 Query: 88 FTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIK 147 T + + + I + T + + + F Sbjct: 102 MTQPTKCFQQYKFDGPLWSCHVVRWN-VCIVTVVEEPTAYVLTLTDRQNAFHCFPLLEQD 160 Query: 148 KG-FFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVK 206 + + L + ++ G + + L +K R E + +K Sbjct: 161 QDISGHGYTLVACPHPTIESIIITGTSKGWINAFQLDLESGFEDKIRCCYEEKIANANIK 220 Query: 207 SLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDE 266 + P + DR IR +++ I + + S +++ +Y Sbjct: 221 QIIIS----PSGTRIAINGSDRTIRQYQL-IVEDNESEGGSSHSVSIELEHKY------- 268 Query: 267 LRVGINFEALIMGHDDWISSLQWHE------SRLQLLA---ATADTSLMVWEPDETSGIW 317 D I+ LQW+ S L+A ++ L +WE S + Sbjct: 269 --------------QDIINRLQWNTIFFSNHSGEYLVASAHGSSAHDLYLWETSSGSLVR 314 Query: 318 VCS 320 V Sbjct: 315 VLE 317 Score = 50.7 bits (119), Expect = 3e-06, Method: Composition-based stats. Identities = 42/386 (10%), Positives = 113/386 (29%), Gaps = 58/386 (15%) Query: 41 WDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTI 100 + ++ + + TL+ A V CV+F P D++ + + I+ + + T Sbjct: 10 FGVLKEYPEKLTHTLEVPVAAV-CVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTH 68 Query: 101 QH-YSKTI--VALSALPSLISVGCADGTISIWRQNIQNDEFGLAH---EFTIKKGFFYPL 154 +++++ V S + D +W F + + Sbjct: 69 SGAHTRSVQSVCWSNDGRYLWSSGRDWYAKLWDMTQPTKCFQQYKFDGPLWSCHVVRWNV 128 Query: 155 CLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQE 214 C+ E Y+L + + D I GH + + Sbjct: 129 CIVTVVEEPTAYVLTLTDRQNAFHCFPLLEQDQDI---------SGHGYTLVAC----PH 175 Query: 215 TPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFE 274 + ++ +G+ +I +++ + +D + + + Sbjct: 176 PTIESIIITGTSKGWINAFQLDLESGFEDKIRCCYEEKIANAN----------------- 218 Query: 275 ALIMGHDDWISSLQWHESRLQLLAATADTSLMVWE-PDETSGIWVCSLRLGEMSSKGAST 333 I + S ++ +D ++ ++ E + S + + Sbjct: 219 ---------IKQIIISPSGTRIAINGSDRTIRQYQLIVEDNESEGGSSHSVSIELEHKYQ 269 Query: 334 ATGSSGGFWSCLWFTHERMDFFLT--NGKTGSWRMWATKDNIICDQRLGISGATKDVTDI 391 + + + + H + +W T + + GA +++ DI Sbjct: 270 DIINRLQWNTIFFSNHSGEYLVASAHGSSAHDLYLWETSSGSLVRV---LEGADEELLDI 326 Query: 392 AWSPSGEYLLATSLDQTTRLFAPWIY 417 W+ + + + + W+Y Sbjct: 327 DWNFYSMRIASNGFE------SGWVY 346 Score = 43.3 bits (100), Expect = 4e-04, Method: Composition-based stats. Identities = 46/258 (17%), Positives = 92/258 (35%), Gaps = 31/258 (12%) Query: 16 KQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTC---VRFVPDSD 72 V + + + + G LWD +P + K + + VR+ Sbjct: 75 SVQSVCWSNDGRYLWSSGRDWYAKLWDMTQPT--KCFQQYK-FDGPLWSCHVVRWNVCIV 131 Query: 73 FMVSASEDHHVKIWKFTDYSHLQCI----QTIQHYSKTIVALSALP---SLISVGCADGT 125 +V + + + + H + Q I + T+VA P S+I G + G Sbjct: 132 TVVEEPTAYVLTLTDRQNAFHCFPLLEQDQDISGHGYTLVAC-PHPTIESIIITGTSKGW 190 Query: 126 ISIWRQNIQ---NDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASF 182 I+ ++ +++ D+ +E I + +S S +AI G++ + Sbjct: 191 INAFQLDLESGFEDKIRCCYEEKIANANIKQIIISPSGT-----RIAINGSDRTIRQYQL 245 Query: 183 ILSDSGIEKC----RVVAELEGHEDWVKSLAFRH---QETPGDYLLCS--GSQDRYIRLW 233 I+ D+ E + ++D + L + G+YL+ S GS + LW Sbjct: 246 IVEDNESEGGSSHSVSIELEHKYQDIINRLQWNTIFFSNHSGEYLVASAHGSSAHDLYLW 305 Query: 234 RIRINDLIDDSEEDSKKL 251 L+ E ++L Sbjct: 306 ETSSGSLVRVLEGADEEL 323 Score = 40.7 bits (93), Expect = 0.003, Method: Composition-based stats. Identities = 20/97 (20%), Positives = 39/97 (40%), Gaps = 18/97 (18%) Query: 557 HGFEI----TCLDISPDQKLIASACRSNNVQ----NAV--IRIFSTENWLEIKPALPFHS 606 H E+ C+ SP +A C + + +++ I + T + H+ Sbjct: 22 HTLEVPVAAVCVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGA--------HT 73 Query: 607 LTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFE 643 ++ + +S DG++L S RD LW+ F+ Sbjct: 74 RSVQSVCWSNDGRYLWSSGRDWYAKLWDMTQPTKCFQ 110 Score = 39.9 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 33/252 (13%), Positives = 79/252 (31%), Gaps = 34/252 (13%) Query: 287 LQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLW 346 +++ L ++ ++++++ D I + G + S W Sbjct: 33 VKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSG-----------AHTRSVQSVCW 81 Query: 347 FTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLD 406 R + ++G+ ++W C Q+ G + W+ ++ Sbjct: 82 SNDGRYLW--SSGRDWYAKLWDMTQPTKCFQQYKFDGPLWSCHVVRWNVC---IVT---- 132 Query: 407 QTTRLFAPWIYDASGRKREIATWHEFSRPQ---IHGYD-MICVETVTDTRFVSG---GDE 459 ++ + R+ + + Q HGY + C ++ ++G G Sbjct: 133 -VVEEPTAYVLTLTDRQNAFHCFPLLEQDQDISGHGYTLVACPHPTIESIIITGTSKGWI 191 Query: 460 KILRSFDLPKGVAGML-----QKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDE 514 + DL G + +K ++ P + + G + +D Sbjct: 192 NAFQL-DLESGFEDKIRCCYEEKIANANIKQIIISPSGTRIAINGSDRTIRQYQLIVEDN 250 Query: 515 EEEGGNKETPDI 526 E EGG+ + I Sbjct: 251 ESEGGSSHSVSI 262 >6BX3-B nrPDB Length = 412 Score = 59.1 bits (141), Expect = 7e-09, Method: Composition-based stats. Identities = 33/268 (12%), Positives = 75/268 (27%), Gaps = 33/268 (12%) Query: 58 HEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLI 117 H +T + + PD ++++S D +K+W + SK + + + Sbjct: 70 HVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKP------------SKPLKEIRFDSPIW 117 Query: 118 SVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLS---LSKVEEKKYLLAIGGTN 174 D + I + +F+ LS + Y+L Sbjct: 118 GCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHT 177 Query: 175 VN--------VFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQ 226 + + + + L+ +K L L Sbjct: 178 KHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQ----NGERLAINCS 233 Query: 227 DRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQ----YKFQIDDELRVGINFEALIMGHDD 282 DR IR + I I+D E + + ++ + H+ Sbjct: 234 DRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHEL 293 Query: 283 WISSLQWHESRLQLLAATADTSLMV-WE 309 +I + +++L + + + W+ Sbjct: 294 YIWE-TTSGTLVRVLEGAEEELIDINWD 320 Score = 52.2 bits (123), Expect = 8e-07, Method: Composition-based stats. Identities = 44/376 (11%), Positives = 115/376 (30%), Gaps = 65/376 (17%) Query: 41 WDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQT- 99 + ++ + + + T++ + C++F P D++ + + I+ + + C+ Sbjct: 8 FAVLKEHPEKLTHTIE-NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPI-CVPGN 65 Query: 100 -IQHYSKTIVALSALPS--LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYP--- 153 + + + I +++ P L+ D +I +W + + + G + Sbjct: 66 MLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAK 125 Query: 154 --LCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFR 211 LC++ E Y++ V ++ + ++ H +V Sbjct: 126 RRLCVATIFEESDAYVIDFSNDPVASLLSKSDE--------KQLSSTPDH-GYVLVCTVH 176 Query: 212 HQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGI 271 T ++ G+ W E L + S+ Sbjct: 177 ---TKHPNIIIVGTSKG----WLDFYKFHSLYQTECIHSLKITSSN-------------- 215 Query: 272 NFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGA 331 I L ++ +L +D ++ +E L L Sbjct: 216 ------------IKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVI 263 Query: 332 STATGSSGGFWSCLWFTHERMDFFLT---NGKTGSWRMWATKDNIICDQRLGISGATKDV 388 + W+C+ F++ ++ + +W T + + GA +++ Sbjct: 264 NKLQ------WNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRV---LEGAEEEL 314 Query: 389 TDIAWSPSGEYLLATS 404 DI W +++ Sbjct: 315 IDINWDFYSMSIVSNG 330 Score = 51.1 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 38/255 (14%), Positives = 82/255 (32%), Gaps = 32/255 (12%) Query: 16 KQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSD--- 72 T ++ + ++ +I LWD +P+ ++ + +++ Sbjct: 73 PITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRF---DSPIWGCQWLDAKRRLC 129 Query: 73 ----------FMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCA 122 +++ S D + +D L Y + P++I VG + Sbjct: 130 VATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDH-GYVLVCTVHTKHPNIIIVGTS 188 Query: 123 DGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASF 182 G + ++ + H I L +S + LAI ++ + Sbjct: 189 KGWLDFYKFHSLYQT-ECIHSLKITSSNIKHLIVS-----QNGERLAINCSDRTIRQYEI 242 Query: 183 ILSDSGIEKCRVVAELEG-HEDWVKSLAFRHQETPGD---YLLCS--GSQDRYIRLWRIR 236 + E V LE ++D + L + + YL+ S GS + +W Sbjct: 243 SI---DDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETT 299 Query: 237 INDLIDDSEEDSKKL 251 L+ E ++L Sbjct: 300 SGTLVRVLEGAEEEL 314 Score = 47.6 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 56/238 (23%), Positives = 90/238 (37%), Gaps = 34/238 (14%) Query: 563 CLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPF-HSLTITRLKFSKDGKFL 621 CL SP +A C + + VI T + + + H IT + +S DG+ L Sbjct: 30 CLQFSPCGDYLALGCANGAL---VIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLL 86 Query: 622 LSVCRDRKWALWE-RNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVK 680 L+ RD LW+ E+RF IW W + T + Sbjct: 87 LTSSRDWSIKLWDLSKPSKPLKEIRF------DSPIWGCQWLDAKRRLCVATIFEESDAY 140 Query: 681 VWRHQKEP-------ADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYS 733 V +P +D+ L ++ H V ++H + +I VG G + Y Sbjct: 141 VIDFSNDPVASLLSKSDEKQLSSTPDHGY-VLVCTVH---TKHPNIIIVGTSKGWLDFYK 196 Query: 734 -YTLGKFELITQLNEDITPADKITRLRWSHL--KRNGKLFLGVGSSDLSTRIYSLAYE 788 ++L + E I L KIT HL +NG+ L + SD + R Y ++ + Sbjct: 197 FHSLYQTECIHSL--------KITSSNIKHLIVSQNGER-LAINCSDRTIRQYEISID 245 Score = 45.3 bits (105), Expect = 1e-04, Method: Composition-based stats. Identities = 19/70 (27%), Positives = 31/70 (44%), Gaps = 2/70 (2%) Query: 344 CLWFTHERMDFFLTNGKTGSWRMWATK-DNIICDQRLGISGATKDVTDIAWSPSGEYLLA 402 CL F+ D+ G+ ++ IC + + +T IAWSP G LL Sbjct: 30 CLQFSPCG-DYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLT 88 Query: 403 TSLDQTTRLF 412 +S D + +L+ Sbjct: 89 SSRDWSIKLW 98 Score = 40.7 bits (93), Expect = 0.003, Method: Composition-based stats. Identities = 27/143 (18%), Positives = 61/143 (42%), Gaps = 13/143 (9%) Query: 3 ECITPEAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDP-IEPNNKGVYATLKGHEAE 61 ECI ++ I ++ + +++ + +TI ++ I+ N V TL+ + Sbjct: 204 ECI--HSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQD 261 Query: 62 V------TCVRFVPDS-DFMVS---ASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALS 111 V C+ F ++ +++V+ S H + IW+ T + ++ ++ + I Sbjct: 262 VINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDF 321 Query: 112 ALPSLISVGCADGTISIWRQNIQ 134 S++S G G + +W I Sbjct: 322 YSMSIVSNGFESGNVYVWSVVIP 344 >5YZG-2 nrPDB Length = 646 Score = 58.8 bits (140), Expect = 8e-09, Method: Composition-based stats. Identities = 36/260 (13%), Positives = 82/260 (31%), Gaps = 50/260 (19%) Query: 58 HEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTI--VALSALPS 115 H +T V +DF+++AS D HVK WK ++ ++ + + I +A+S+ + Sbjct: 89 HRDVITHV-VCTKTDFIITASHDGHVKFWKKI-EEGIEFVKHFRSHLGVIESIAVSSEGA 146 Query: 116 LISVGCADGTISIWRQ------NIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLA 169 L D + ++ N+ + I ++ S+ K + Sbjct: 147 LFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYCPGDAISSVAASEKSTGKIFIY 206 Query: 170 IG-GTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDR 228 G G N + I + H + + + S + Sbjct: 207 DGRGDNQPLHIFDKL-----------------HTSPLTQIRLNPVY----KAVVSSDKSG 245 Query: 229 YIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQ 288 I W + N ++++ D +L +A +S+ Sbjct: 246 MIEYW-----------TGPPHEYKFPKNVNWEYKTDTDLYEFAKCKAYP-------TSVC 287 Query: 289 WHESRLQLLAATADTSLMVW 308 + ++ +D + ++ Sbjct: 288 FSPDGKKIATIGSDRKVRIF 307 Score = 54.1 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 43/319 (13%), Positives = 104/319 (32%), Gaps = 17/319 (5%) Query: 8 EAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRF 67 E ++ + T V K I+ + W IE + H + + Sbjct: 84 ERSYMHRDVITHVV-CTKTDFIITASHDGHVKFWKKIE-EGIEFVKHFRSHLGVIESIAV 141 Query: 68 VPDSDFMVSASEDHHVKIWKFTDYSHLQCIQ--TIQHYSKTIVAL-SALPSLISVGCADG 124 + S +D +K++ ++ + ++ + I A+ S+ + + G Sbjct: 142 SSEGALFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYCPGDAISSVAASEKSTG 201 Query: 125 TISIWR---QNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIAS 181 I I+ N F H + + P+ ++ ++ + G Sbjct: 202 KIFIYDGRGDNQPLHIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFPK 261 Query: 182 FILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLI 241 + + + + E + + S+ F P + + DR +R++R L+ Sbjct: 262 NVNWEYKTDTD--LYEFAKCKAYPTSVCFS----PDGKKIATIGSDRKVRIFRFVTGKLM 315 Query: 242 DDSEEDSKKLT-LLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAAT 300 +E T L +Q ++ R+ + E + I+ + + E+ +L T Sbjct: 316 RVFDESLSMFTELQQMRQQLPDMEFGRRMAVERELEKVDAVRLIN-IVFDETGHFVLYGT 374 Query: 301 ADTSLMVWEPDETSGIWVC 319 + V + + + Sbjct: 375 M-LGIKVINVETNRCVRIL 392 Score = 36.0 bits (81), Expect = 0.057, Method: Composition-based stats. Identities = 34/251 (13%), Positives = 77/251 (30%), Gaps = 51/251 (20%) Query: 167 LLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQ 226 + + +V I E V H ++S+A + L CS Sbjct: 103 FIITASHDGHVKFWKKIE-----EGIEFVKHFRSHLGVIESIAVSSE----GALFCSVGD 153 Query: 227 DRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISS 286 D+ ++++ + D+I + L++G G +WI Sbjct: 154 DKAMKVFDVVNFDMI-----------------------NMLKLGYFP-----GQCEWIYC 185 Query: 287 LQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLW 346 + +AA+ ++ ++ D L + + T + + + + Sbjct: 186 ---PGDAISSVAASEKSTGKIFIYDGRGDNQ--PLHIFDKLHTSPLTQIRLNPVYKAVVS 240 Query: 347 FTHERMDFFLTNGKTGSWRMWATKDNIICDQR-----LGISGATKDVTDIAWSPSGEYLL 401 M + TG + N+ + + + T + +SP G+ + Sbjct: 241 SDKSGMIEY----WTGPPHEYKFPKNVNWEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIA 296 Query: 402 ATSLDQTTRLF 412 D+ R+F Sbjct: 297 TIGSDRKVRIF 307 >3I2N-A nrPDB Length = 357 Score = 58.8 bits (140), Expect = 1e-08, Method: Composition-based stats. Identities = 41/298 (13%), Positives = 88/298 (29%), Gaps = 43/298 (14%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDS------DFMVSAS 78 + + + G + +W+ P ++KGH+ + + + +V+ S Sbjct: 79 QQRYLATGDFGGNLHIWNLEAPE--MPVYSVKGHKEIINAIDGIGGLGIGEGAPEIVTGS 136 Query: 79 EDHHVKIWKFTD----YSHLQCIQTIQHYSKTIVALSAL---PSLISVGCAD-GTISIWR 130 D VK+W ++++ +Q VA + D G I ++ Sbjct: 137 RDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFD 196 Query: 131 QNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIE 190 L E IK G K ++ G F + Sbjct: 197 L----RNMALRWETNIKNGVCSLEFDRKDISMNKLVATSLEG-----KFHVFDMRTQHPT 247 Query: 191 KCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKK 250 K + H+ V + Q L + + LW+ + + + Sbjct: 248 KGFASVSEKAHKSTVWQVRHLPQNRE---LFLTAGGAGGLHLWKYEYPIQRSKKDSEGIE 304 Query: 251 LTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQL-LAATADTSLMV 307 + + + + + + ISSL W + L + ++ D ++ V Sbjct: 305 MGVAGS----VSLLQNVTLSTQP----------ISSLDWSPDKRGLCVCSSFDQTVRV 348 Score = 50.7 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 20/116 (17%), Positives = 46/116 (39%), Gaps = 3/116 (2%) Query: 619 KFLLSVCRDRKWALWERNMED-NTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDK 677 ++L + +W + + ++ E + VT SRD Sbjct: 81 RYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPE-IVTGSRDG 139 Query: 678 TVKVWRHQKEPADDYVLEASIK-HTKAVTAISIHDSMIREKILISVGLENGEIYLY 732 TVKVW +++ +E + + ++ ++ +E+ ++ G +NG+I L+ Sbjct: 140 TVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLF 195 Score = 49.5 bits (116), Expect = 6e-06, Method: Composition-based stats. Identities = 51/300 (17%), Positives = 104/300 (34%), Gaps = 62/300 (20%) Query: 154 LCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQ 213 C + ++ LA G N+ I + + V ++GH++ + ++ Sbjct: 69 KCGTFGATSLQQRYLATGDFGGNLHIWNLEAPEMP------VYSVKGHKEIINAIDGIGG 122 Query: 214 ETPG--DYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKL------TLLSNKQY------ 259 G + +GS+D +++W R D + E + T+ Y Sbjct: 123 LGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERV 182 Query: 260 -KFQIDD------ELR-VGINFEALIMGHDDWISSLQWHE---SRLQLLAATADTSLMVW 308 D+ +LR + + +E I + + SL++ S +L+A + + V+ Sbjct: 183 VCAGYDNGDIKLFDLRNMALRWETNI---KNGVCSLEFDRKDISMNKLVATSLEGKFHVF 239 Query: 309 EPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWA 368 + + + W R F LT G G +W Sbjct: 240 DMRTQH----------PTKGFASVSEKAHKSTVWQVRHLPQNRELF-LTAGGAGGLHLWK 288 Query: 369 TKDNIICDQR------LGISGA----------TKDVTDIAWSPSGEYLL-ATSLDQTTRL 411 + I ++ +G++G+ T+ ++ + WSP L +S DQT R+ Sbjct: 289 YEYPIQRSKKDSEGIEMGVAGSVSLLQNVTLSTQPISSLDWSPDKRGLCVCSSFDQTVRV 348 Score = 30.3 bits (66), Expect = 3.6, Method: Composition-based stats. Identities = 16/131 (12%), Positives = 38/131 (29%), Gaps = 16/131 (12%) Query: 288 QWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWF 347 + L +L +W + + S KG + Sbjct: 75 ATSLQQRYLATGDFGGNLHIWNLEAPE--------MPVYSVKGHKEII--NAIDGIGGLG 124 Query: 348 THERMDFFLTNGKTGSWRMWATK--DNIICDQRLGISGATKDVTDIAW----SPSGEYLL 401 E +T + G+ ++W + D+ + + +D +A+ + + Sbjct: 125 IGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVC 184 Query: 402 ATSLDQTTRLF 412 A + +LF Sbjct: 185 AGYDNGDIKLF 195 Score = 29.9 bits (65), Expect = 4.9, Method: Composition-based stats. Identities = 16/123 (13%), Positives = 36/123 (29%), Gaps = 16/123 (13%) Query: 354 FFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPS------GEYLLATSLDQ 407 + T G+ +W + + + G + + I ++ S D Sbjct: 82 YLATGDFGGNLHIWNLEAPEMPVYSV--KGHKEIINAIDGIGGLGIGEGAPEIVTGSRDG 139 Query: 408 TTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETV--TDTRFVSGGDEK-ILRS 464 T + ++D + +A + + R V G + ++ Sbjct: 140 TVK-----VWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKL 194 Query: 465 FDL 467 FDL Sbjct: 195 FDL 197 >1PI6-A nrPDB Length = 615 Score = 58.8 bits (140), Expect = 1e-08, Method: Composition-based stats. Identities = 61/456 (13%), Positives = 134/456 (29%), Gaps = 82/456 (17%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYAT-LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWK 87 ++ G+ + I+ +D + + + + ++ DS + D +++W Sbjct: 222 VITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWL-DSQKFATVGADATIRVWD 280 Query: 88 FTDYSHLQ--CIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQND-EFGLAHEF 144 T +Q + Q ++ + ++ I DGT++ + + H Sbjct: 281 VTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNK 340 Query: 145 TIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDW 204 I PL G + + S H + Sbjct: 341 GITALTVNPLI--------------SGSYDGRIMEWSSSSMHQD------------HSNL 374 Query: 205 VKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQI- 263 + SL S S D +++ + I E S+ +N + Sbjct: 375 IVSLD-----NSKAQEYSSISWDDTLKV------NGITKHEFGSQPKVASANNDGFTAVL 423 Query: 264 --DDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSL 321 DD+L + +F I I S++ + A + + + +E + I V L Sbjct: 424 TNDDDLLILQSFTGDI------IKSVRLNSPGS---AVSLSQNYVAVGLEEGNTIQVFKL 474 Query: 322 RLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGI 381 E+S + + G ++ + + R Sbjct: 475 SDLEVSFDLKTPLRAKPSYISIS-----PSETYIAAGDVMGKILLYDLQSREVKTSRWAF 529 Query: 382 SGATKDVTDIAWSPSGE----------YLLATSLDQTTRLFAPWIYDASGRKREIATWHE 431 T + I+W P+ + + SLD +IY + I + Sbjct: 530 R--TSKINAISWKPAEKGANEEEIEEDLVATGSLDTNI-----FIYSVKRPMKIIKALN- 581 Query: 432 FSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDL 467 H + + T + VS G + ++ +++ Sbjct: 582 -----AHKDGVNNLLWETPSTLVSSGADACIKRWNV 612 Score = 56.8 bits (135), Expect = 3e-08, Method: Composition-based stats. Identities = 61/395 (15%), Positives = 122/395 (30%), Gaps = 54/395 (13%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVK 84 +K GA TI +WD + K + ++S S D + Sbjct: 263 DSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTL- 321 Query: 85 IWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEF 144 F + H + ++TI ++K I AL+ P + G DG I W + H+ Sbjct: 322 --NFYELGHDEVLKTISGHNKGITALTVNP--LISGSYDGRIMEWSSSS-------MHQD 370 Query: 145 TIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDW 204 L +SL + ++Y + V + S + + Sbjct: 371 HSN------LIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANND------- 417 Query: 205 VKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQID 264 F T D LL S I + +R+N + + + Q+ Sbjct: 418 ----GFTAVLTNDDDLLILQSFTGDI-IKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVF 472 Query: 265 --DELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLR 322 +L V + + + +IS S + A +++++ V + R Sbjct: 473 KLSDLEVSFDLKTPLRAKPSYIS---ISPSETYIAAGDVMGKILLYDLQSRE---VKTSR 526 Query: 323 LGEMSSKGAS-----TATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQ 377 +SK + G++ D T + +++ K + + Sbjct: 527 WAFRTSKINAISWKPAEKGANEEEIE--------EDLVATGSLDTNIFIYSVKRPMKIIK 578 Query: 378 RLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLF 412 L V ++ W L+++ D + + Sbjct: 579 ALN--AHKDGVNNLLWETPST-LVSSGADACIKRW 610 Score = 51.8 bits (122), Expect = 1e-06, Method: Composition-based stats. Identities = 53/445 (11%), Positives = 122/445 (27%), Gaps = 81/445 (18%) Query: 43 PIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQH 102 P +P+ + + T ++ + + V +D K+ + Sbjct: 11 PPQPSTQRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKV---------PPVVQFTG 61 Query: 103 YSKTIV-----ALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLS 157 + ++V + + G G + +W + + + Sbjct: 62 HGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISD 121 Query: 158 LSKVEEKKYLLAIG-GTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETP 216 +S E + L +G G + S+ + + E+ GH + + + Sbjct: 122 ISWDFEGRRLCVVGEGRDNFGVFISW-------DSGNSLGEVSGHSQRINACHLKQSRPM 174 Query: 217 GDYLLCSGSQDRYIRLW---------RIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDEL 267 + D + + R + D + D ++ Sbjct: 175 RS---MTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKI 231 Query: 268 RVGINFEALIMGH--------DDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVC 319 + + I +L W + AD ++ VW+ + + Sbjct: 232 SCFDGKSGEFLKYIEDDQEPVQGGIFALSW-LDSQKFATVGADATIRVWDVTTSKCVQKW 290 Query: 320 SLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRL 379 +L ++ ++ +G S + + F G + Sbjct: 291 TLDKQQLGNQQVGVVATGNGRIIS---LSLDGTLNFYELGHDEVLK-------------- 333 Query: 380 GISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHG 439 ISG K +T + +P L++ S D GR E W S Q H Sbjct: 334 TISGHNKGITALTVNP----LISGSYD--------------GRIME---WSSSSMHQDHS 372 Query: 440 YDMICVETVTDTRFVSGGDEKILRS 464 ++ ++ + S + L+ Sbjct: 373 NLIVSLDNSKAQEYSSISWDDTLKV 397 Score = 33.7 bits (75), Expect = 0.33, Method: Composition-based stats. Identities = 25/147 (17%), Positives = 52/147 (35%), Gaps = 15/147 (10%) Query: 571 KLIASACRSNNVQNAVIRIFS-TENWLEIKPALPFHSLTITRLKFSKDGK-FLLSVCRDR 628 + S + +A IR++ T + K L L ++ G ++S+ D Sbjct: 260 SWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDG 319 Query: 629 KWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEP 688 +E ++ + N+ + N ++ S D + W Sbjct: 320 TLNFYELGHDEVLKTISGHNKGITALTV-----------NPLISGSYDGRIMEWSSSSMH 368 Query: 689 ADDYVLEASIKHTKA--VTAISIHDSM 713 D L S+ ++KA ++IS D++ Sbjct: 369 QDHSNLIVSLDNSKAQEYSSISWDDTL 395 >4E5Z-B nrPDB Length = 436 Score = 58.0 bits (138), Expect = 2e-08, Method: Composition-based stats. Identities = 29/257 (11%), Positives = 66/257 (25%), Gaps = 53/257 (20%) Query: 63 TCVRFVPDSD-FMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP---SLIS 118 T + + P + S+ + +W F +I L P + Sbjct: 123 TSLAWHPTHPSTVAVGSKGGDIMLWNF-GIKDKPTFIKGIGAGGSITGLKFNPLNTNQFY 181 Query: 119 VGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVF 178 +GT + + + V ++ G NV Sbjct: 182 ASSMEGTTRLQDF---KGNILRVFASSDTINIW----FCSLDVSASSRMVVTGDNVGNVI 234 Query: 179 IASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRIN 238 + + + + L H+ V +A D+ L + S D+ +++W +R Sbjct: 235 LLNM--------DGKELWNLRMHKKKVTHVALNPCC---DWFLATASVDQTVKIWDLRQV 283 Query: 239 DLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLA 298 G + H +++ + +LL Sbjct: 284 R------------------------------GKASFLYSLPHRHPVNAACFSPDGARLLT 313 Query: 299 ATADTSLMVWEPDETSG 315 + + V+ + Sbjct: 314 TDQKSEIRVYSASQWDC 330 Score = 56.8 bits (135), Expect = 3e-08, Method: Composition-based stats. Identities = 27/204 (13%), Positives = 62/204 (30%), Gaps = 17/204 (8%) Query: 21 SDIHKVKKIVAFGAG-KTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDF-MVSAS 78 D+ ++V G + L + L+ H+ +VT V P D+ + +AS Sbjct: 215 LDVSASSRMVVTGDNVGNVILLNMDGKE----LWNLRMHKKKVTHVALNPCCDWFLATAS 270 Query: 79 EDHHVKIWKFTDYSHLQCIQTIQHYSKTIV--ALSALPSLISVGCADGTISIWRQNIQND 136 D VKIW + + S + + I ++ + + Sbjct: 271 VDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDC 330 Query: 137 EFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVA 196 GL + F + + + ++ + N + + R + Sbjct: 331 PLGLI--PHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCT-------PYELRTID 381 Query: 197 ELEGHEDWVKSLAFRHQETPGDYL 220 +G+ + + + + L Sbjct: 382 VFDGNSGKMMCQLYDPESSGISSL 405 Score = 49.9 bits (117), Expect = 4e-06, Method: Composition-based stats. Identities = 39/246 (15%), Positives = 72/246 (29%), Gaps = 34/246 (13%) Query: 187 SGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDL------ 240 ++ R++ + + SLA+ + GS+ I LW I D Sbjct: 104 HTLDSYRILQKAAPFDRRATSLAWHPTHPST---VAVGSKGGDIMLWNFGIKDKPTFIKG 160 Query: 241 --IDDSEEDSKKLTLLSNKQYKFQIDDELRVG--INFEALIMGHDD----WISSLQWHES 292 S K L +N+ Y ++ R+ + D W SL S Sbjct: 161 IGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSAS 220 Query: 293 RLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERM 352 ++ ++++ D +W + + C W Sbjct: 221 SRMVVTGDNVGNVILLNMDGKE-LW---------NLRMHKKKVTHVALNPCCDW------ 264 Query: 353 DFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLF 412 F T + ++W + L V +SP G LL T R++ Sbjct: 265 -FLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVY 323 Query: 413 APWIYD 418 + +D Sbjct: 324 SASQWD 329 Score = 32.2 bits (71), Expect = 1.0, Method: Composition-based stats. Identities = 33/167 (19%), Positives = 57/167 (34%), Gaps = 25/167 (14%) Query: 556 GHGFEITCLDISPDQKLIASAC------RSNNVQNAVIRIFSTENWLEIKPALPFHSLTI 609 G G IT L +P A R + + ++R+F++ + + I Sbjct: 162 GAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCS------- 214 Query: 610 TRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKP-HTRIIWDADWAPLEFGN 668 L S + +++ L + + LR +K H + DW Sbjct: 215 --LDVSASSRMVVTGDNVGNVILLNMD-GKELWNLRMHKKKVTHVALNPCCDW------- 264 Query: 669 VFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIR 715 TAS D+TVK+W ++ L + + H V A R Sbjct: 265 FLATASVDQTVKIWDLRQVRGKASFLYS-LPHRHPVNAACFSPDGAR 310 >5A9Q-2 nrPDB Length = 326 Score = 57.6 bits (137), Expect = 2e-08, Method: Composition-based stats. Identities = 38/288 (13%), Positives = 83/288 (28%), Gaps = 46/288 (15%) Query: 44 IEPNNKGVYATLKGHEAEVTCVRFVPDSDF--------MVSASEDHHVKIW--KFTDYSH 93 +E T H V + + P++ +++ D ++++ D + Sbjct: 58 VEGIQYKTLRTFH-HGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNE 116 Query: 94 LQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYP 153 + ++ + +V I+ D T IW + H + Sbjct: 117 YKVLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFVLHSPGMS------ 170 Query: 154 LCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQ 213 + E K ++A + + + +E + V + H W F+ Sbjct: 171 --VCWHPEETFKLMVAEKNGTIRFYDLLAQQAILSLESEQ-VPLMSAH--WCLKNTFKVG 225 Query: 214 ETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDS-KKLTLLS----NKQYKFQIDDELR 268 G+ L +W I + + + L ++ + Sbjct: 226 AVAGNDWL----------IWDITRSSYPQNKRPVHMDRACLFRWSTISENLFATTGYPGK 275 Query: 269 VGINFEALIMGHDDWI--------SSLQWHESRLQLLAATADTSLMVW 308 + F+ +GH I S L WH + + D L+ W Sbjct: 276 MASQFQIHHLGHPQPILMGSVAVGSGLSWHRTLPLCVIGG-DHKLLFW 322 Score = 36.4 bits (82), Expect = 0.050, Method: Composition-based stats. Identities = 26/137 (18%), Positives = 50/137 (36%), Gaps = 23/137 (16%) Query: 605 HSLTITRLKFSKDG---------KFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRI 655 H + + + +S + KF S D K L+ +++D +K + HT Sbjct: 71 HGVRVDGIAWSPETRLDSLPPVIKFCTSAA-DMKIRLFTSDLQDKN---EYKVLEGHTDF 126 Query: 656 IWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIR 715 I + P E + S D T ++W + +VL + ++ H Sbjct: 127 INGLVFDPKEG-QEIASVSDDHTCRIWNLEGVQTAHFVLHSP------GMSVCWHPEETF 179 Query: 716 EKILISVGLENGEIYLY 732 + ++ +NG I Y Sbjct: 180 KLMVAE---KNGTIRFY 193 Score = 34.5 bits (77), Expect = 0.20, Method: Composition-based stats. Identities = 13/94 (13%), Positives = 34/94 (36%), Gaps = 9/94 (9%) Query: 20 VSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDF-MVSAS 78 V D + ++I + T +W+ A H V + P+ F ++ A Sbjct: 131 VFDPKEGQEIASVSDDHTCRIWNLEGVQT----AHFVLHSPG-MSVCWHPEETFKLMVAE 185 Query: 79 EDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSA 112 ++ ++ + Q I +++ +++ Sbjct: 186 KNGTIRFYDLL---AQQAILSLESEQVPLMSAHW 216 Score = 32.9 bits (73), Expect = 0.49, Method: Composition-based stats. Identities = 30/221 (13%), Positives = 58/221 (26%), Gaps = 53/221 (23%) Query: 202 EDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKF 261 ED+V + F E L + + Y+ + F Sbjct: 16 EDYVHVVEFNPFENGDSGNLIAYGGNNYVVI------------------------GTCTF 51 Query: 262 QIDDELRVGINFEALIMGHDD-WISSLQWHESRL--------QLLAATADTSLMVWEPDE 312 Q ++ GI ++ L H + + W + + AD + ++ D Sbjct: 52 QEEEADVEGIQYKTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDL 111 Query: 313 TSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDN 372 K F + L F + + + R+W + Sbjct: 112 QD--------------KNEYKVLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGV 157 Query: 373 IICDQRLGISGATKDVTDIAWSPSGEY-LLATSLDQTTRLF 412 L G + W P + L+ + T R + Sbjct: 158 QTAHFVLHSPG-----MSVCWHPEETFKLMVAEKNGTIRFY 193 >6F1U-h nrPDB Length = 612 Score = 56.8 bits (135), Expect = 3e-08, Method: Composition-based stats. Identities = 22/147 (14%), Positives = 49/147 (33%), Gaps = 17/147 (11%) Query: 45 EPNNKGVYATLKGHEAEVTC---------VRFVPDSDFMVSASEDHHVKIWKFTDYSHLQ 95 + G+ +GH+ +T V F V++S D VK+W + L Sbjct: 436 HGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSH---LFVTSSFDWTVKLWSTKNNKPLY 492 Query: 96 CIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQN----IQNDEFGLAHEFTIKKGFF 151 + Y ++ P+L + G + +W N + + + + + Sbjct: 493 SFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRW 552 Query: 152 YPLCLSLS-KVEEKKYLLAIGGTNVNV 177 ++ E + ++ G + V Sbjct: 553 THSGREIAVGDSEGQIVIYDVGEQIAV 579 Score = 55.3 bits (131), Expect = 1e-07, Method: Composition-based stats. Identities = 34/269 (12%), Positives = 85/269 (31%), Gaps = 31/269 (11%) Query: 66 RFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQT---IQHYSKTIVALSALPSL----IS 118 +F P+ +V + + +W +T ++ + ++ + + + Sbjct: 316 KFHPN--LVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLI 373 Query: 119 VGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVF 178 DG I W ++ + + K S+S +G +V+ Sbjct: 374 SISTDGKICSWSLDMLSHPQDSME--LVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVY 431 Query: 179 IASFILSDSGIEKCRVVAELEGHEDWVK--SLAFRHQETPGDYLLCSGSQDRYIRLWRIR 236 A S +GI + EGH+ + +L + S D ++LW + Sbjct: 432 TACRHGSKAGISE-----MFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTK 486 Query: 237 IND---LIDDSEEDSKKLTLLSNKQYKFQ---------IDDELRVGINFEALIMGHDD-W 283 N +D+ + F + + A I + Sbjct: 487 NNKPLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPA 546 Query: 284 ISSLQWHESRLQLLAATADTSLMVWEPDE 312 ++ ++W S ++ ++ +++++ E Sbjct: 547 LNRVRWTHSGREIAVGDSEGQIVIYDVGE 575 Score = 51.4 bits (121), Expect = 2e-06, Method: Composition-based stats. Identities = 17/109 (15%), Positives = 36/109 (33%), Gaps = 8/109 (7%) Query: 28 KIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVK--I 85 V T+ LW N + + + V V + P + + D + + Sbjct: 470 LFVTSSFDWTVKLWST---KNNKPLYSFEDNAGYVYDVMWSPTHPALFAC-VDGMGRLDL 525 Query: 86 WKFTDYSHLQCIQTIQHYSKTIVALSALPSL--ISVGCADGTISIWRQN 132 W + + + + + + S I+VG ++G I I+ Sbjct: 526 WNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVG 574 Score = 50.3 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 45/267 (16%), Positives = 89/267 (33%), Gaps = 36/267 (13%) Query: 6 TPEAIFIGANKQTQVSDIH-KVKKIVAFGAGKTIALWDPIEPNNKGVYA----TLKGHEA 60 TPE +F + + +V I LWD N + + H Sbjct: 298 TPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLWD-NRSNKRTPVQRTPLSAAAHTH 356 Query: 61 EVTCVRFV--PDSDFMVSASEDHHVKIWKFTDYSHLQ---CIQTIQHYSKTIVALSA--- 112 V CV V ++ ++S S D + W SH Q + Q + + ++S Sbjct: 357 PVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVG 416 Query: 113 LPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGF-FYPLCLSLSKVEEKKYLLAIG 171 + VG +G++ + + G++ F +G C + + +L Sbjct: 417 DVNNFVVGSEEGSV--YTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTS 474 Query: 172 GTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIR 231 + V + S + + + E + +V + + P L D R Sbjct: 475 SFDWTVKLWS-------TKNNKPLYSFEDNAGYVYDVMWS----PTHPALF-ACVDGMGR 522 Query: 232 --LWRIRINDLIDDSEEDSKKLTLLSN 256 LW + +D+E + +++ N Sbjct: 523 LDLWNL-----NNDTEVPTASISVEGN 544 Score = 46.0 bits (107), Expect = 7e-05, Method: Composition-based stats. Identities = 41/235 (17%), Positives = 86/235 (36%), Gaps = 17/235 (7%) Query: 556 GHGFEITCLDISPDQKL--IASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLK 613 H + C+++ Q + S + + + + S ++ +T + Sbjct: 353 AHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMS 412 Query: 614 FSKD--GKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFV 671 F F++ + + E+ ++ P T I A ++F ++FV Sbjct: 413 FPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFV 472 Query: 672 TASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYL 731 T+S D TVK+W + Y E + + V H ++ + +G + L Sbjct: 473 TSSFDWTVKLWSTKNNKPL-YSFEDNAGYVYDVMWSPTHPALFA--CVDGMG----RLDL 525 Query: 732 YSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYSLA 786 ++ ++ + PA + R+RW+H R + VG S+ IY + Sbjct: 526 WNLNNDTEVPTASISVEGNPA--LNRVRWTHSGRE----IAVGDSEGQIVIYDVG 574 Score = 36.8 bits (83), Expect = 0.035, Method: Composition-based stats. Identities = 41/243 (16%), Positives = 79/243 (32%), Gaps = 39/243 (16%) Query: 561 ITCLDISPDQKLIASACRSNNVQ-----NAVIRIFSTENWLEIKPALPFH-SLTITRLKF 614 ++CLD S + A +NN + V +++ + + + P FH + F Sbjct: 256 VSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMK-YKKTTPEYVFHCQSAVMSATF 314 Query: 615 SK-DGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKP-HTRIIWDADWAPLEFGNVFVT 672 +K ++ + LW+ T R HT ++ + + + ++ Sbjct: 315 AKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLIS 374 Query: 673 ASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIY-- 730 S D + W +E K +KAV A++ + + VG E G +Y Sbjct: 375 ISTDGKICSWSLDMLSHPQDSMELVHKQSKAV-AVTSMSFPVGDVNNFVVGSEEGSVYTA 433 Query: 731 ------------LYSYT-----------LGKFELITQLNEDITPADKITRLRWSHLKRNG 767 + +G + +T + T WS K N Sbjct: 434 CRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLF---VTSSFDWTVKLWS-TKNNK 489 Query: 768 KLF 770 L+ Sbjct: 490 PLY 492 >5OV3-A nrPDB Length = 381 Score = 56.4 bits (134), Expect = 5e-08, Method: Composition-based stats. Identities = 44/315 (13%), Positives = 89/315 (28%), Gaps = 49/315 (15%) Query: 26 VKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKI 85 + I +WD + + + H V + + D +VSAS D+ V Sbjct: 37 GTLLAVGCNDGRIVIWDFLTRGIAKIIS---AHIHPVCSLCWSRDGHKLVSASTDNIVSQ 93 Query: 86 WKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFT 145 W Q + + I+ + P D + +++ L + Sbjct: 94 WDVLSGDCDQRFR----FPSPILKVQYHP-------RDQN-KVLVCPMKSAPVMLTLSDS 141 Query: 146 IKKG----FFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGH 201 L + S +Y + G + + + V + Sbjct: 142 KHVVLPVDDDSDLNVVASFDRRGEY-IYTGNAKGKILV--LKTDSQDLVASFRVTTGTSN 198 Query: 202 EDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTL------LS 255 +KS+ F + + DR IR++ R E L Sbjct: 199 TTAIKSIEFARK----GSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTP 254 Query: 256 NKQYKFQIDDEL---------------RVGINFEALIMGHDDW-ISSLQWHESRLQLLAA 299 K+ F D E + N ++ G + + WH R ++A+ Sbjct: 255 WKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRP-IIAS 313 Query: 300 TADTSLMVWEPDETS 314 + + +W ++ Sbjct: 314 ISSGVVSIWAQNQVE 328 Score = 52.6 bits (124), Expect = 6e-07, Method: Composition-based stats. Identities = 33/313 (10%), Positives = 85/313 (27%), Gaps = 25/313 (7%) Query: 65 VRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADG 124 F + D + IW F + I H ++ S + D Sbjct: 31 CTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSL-CWSRDGHKLVSASTDN 89 Query: 125 TISIWRQNIQNDEFGLAHEFTIKKGFFYPLC---LSLSKVEEKKYLLAIGGTNVNVFIAS 181 +S W + + I K ++P + + ++ +L + + V Sbjct: 90 IVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVD 149 Query: 182 FILSDSGIEKC--RVVAELEGH-EDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRIN 238 + + R G+ + + L Q+ + + +G+ + Sbjct: 150 DDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFAR 209 Query: 239 DLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLA 298 + ++ + + + + + + + + ++A Sbjct: 210 KGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVA 269 Query: 299 ATADT-SLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLT 357 +A +L +WE + + + GE+ W H + Sbjct: 270 GSARQHALYIWEKSIGNLVKILHGTRGELLLD--------------VAW--HPVRPIIAS 313 Query: 358 NGKTGSWRMWATK 370 +G +WA Sbjct: 314 IS-SGVVSIWAQN 325 Score = 49.1 bits (115), Expect = 8e-06, Method: Composition-based stats. Identities = 31/233 (13%), Positives = 74/233 (31%), Gaps = 16/233 (6%) Query: 14 ANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVP--DS 71 + + K+V+ ++ WD + + + + + V++ P + Sbjct: 67 IHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRF----PSPILKVQYHPRDQN 122 Query: 72 DFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQ 131 +V + V + +D H+ + + I G A G I + + Sbjct: 123 KVLVCPMKSAPVMLT-LSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKT 181 Query: 132 NIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFIL---SDSG 188 + D T + ++ +L+ + V+ IL D Sbjct: 182 DS-QDLVASFRVTTGTSNTTAIKSIEFARKGSC-FLINTADRIIRVYDGREILTCGRDGE 239 Query: 189 IEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLI 241 E + + +L W K G+Y++ ++ + +W I +L+ Sbjct: 240 PEPMQKLQDLVNRTPWKKCC----FSGDGEYIVAGSARQHALYIWEKSIGNLV 288 Score = 46.0 bits (107), Expect = 6e-05, Method: Composition-based stats. Identities = 49/316 (15%), Positives = 104/316 (32%), Gaps = 22/316 (6%) Query: 102 HYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKV 161 + T +L++VGC DG I IW + G+A + LC S+ Sbjct: 26 SMALTCTFNRW-GTLLAVGCNDGRIVIWDFLTR----GIAKIISAHIHPVCSLC--WSRD 78 Query: 162 EEKKYLLAIGGTNVNVFIASFILSDSGIEKC--RVVAELEGHEDWVKSLAFRHQETPGDY 219 K L T+ V + D + +++ H + ++ Sbjct: 79 GHK---LVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVM 135 Query: 220 LLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMG 279 L S S+ + + +++ + + + + K + + + + + G Sbjct: 136 LTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTG 195 Query: 280 HDD--WISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGS 337 + I S+++ L TAD + V++ I C R GE + Sbjct: 196 TSNTTAIKSIEFARKGSCFLINTADRIIRVYD---GREILTCG-RDGEPEPMQKLQDLVN 251 Query: 338 SGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSG 397 + C F+ + + + + +W + G G + D+AW P Sbjct: 252 RTPWKKCC-FSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGEL--LLDVAWHPV- 307 Query: 398 EYLLATSLDQTTRLFA 413 ++A+ ++A Sbjct: 308 RPIIASISSGVVSIWA 323 Score = 41.4 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 23/120 (19%), Positives = 37/120 (30%), Gaps = 10/120 (8%) Query: 564 LDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLS 623 + L+A C + + H + L +S+DG L+S Sbjct: 31 CTFNRWGTLLAVGCNDGRIVIWDFLTRGIAK------IISAHIHPVCSLCWSRDGHKLVS 84 Query: 624 VCRDRKWALWERNMEDNTFELRF----KNEKPHTRIIWDADWAPLEFGNVFVTASRDKTV 679 D + W+ D RF + H R P++ V +T S K V Sbjct: 85 ASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHV 144 Score = 35.6 bits (80), Expect = 0.087, Method: Composition-based stats. Identities = 34/202 (16%), Positives = 61/202 (30%), Gaps = 40/202 (19%) Query: 614 FSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTA 673 F++ G L C D + +W D K H + W+ G+ V+A Sbjct: 33 FNRWGTLLAVGCNDGRIVIW-----DFLTRGIAKIISAHIHPVCSLCWS--RDGHKLVSA 85 Query: 674 SRDKTVKVWRHQKEPADD-----YVLEASIKHTKAVTAISIHDSMIREKILISVG----- 723 S D V W D + H + + + +L Sbjct: 86 STDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVV 145 Query: 724 --LEN-------------GEIYLYSYTLGKFELITQLNEDI-------TPADKITRLRWS 761 +++ GE GK ++ ++D+ T T ++ Sbjct: 146 LPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSI 205 Query: 762 HLKRNGKLFLGVGSSDLSTRIY 783 R G FL + ++D R+Y Sbjct: 206 EFARKGSCFL-INTADRIIRVY 226 >3DWL-C nrPDB Length = 377 Score = 55.7 bits (132), Expect = 8e-08, Method: Composition-based stats. Identities = 43/220 (19%), Positives = 82/220 (37%), Gaps = 28/220 (12%) Query: 28 KIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWK 87 + V A + L++ N T H+ VTCV + P S+ +V+ S+D + +++ Sbjct: 25 EFVTTTATNQVELYEQDG-NGWKHARTFSDHDKIVTCVDWAPKSNRIVTCSQDRNAYVYE 83 Query: 88 FT-DYSHLQCIQTIQ-HYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFT 145 D + Q + ++ + + T V S +VG IS+ F +++ Sbjct: 84 KRPDGTWKQTLVLLRLNRAATFVRWSPNEDKFAVGSGARVISV-------CYFEQENDWW 136 Query: 146 IKKGFFYPLCLSLSKVE--EKKYLLAIGGTNVNVFIASFILSDSGIEK-----------C 192 + K PL ++ ++ LLA G + ++ S + D + Sbjct: 137 VSKHLKRPLRSTILSLDWHPNNVLLAAGCADRKAYVLSAYVRDVDAKPEASVWGSRLPFN 196 Query: 193 RVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRL 232 V AE WV ++ F P L D + + Sbjct: 197 TVCAEYPS-GGWVHAVGFS----PSGNALAYAGHDSSVTI 231 Score = 50.3 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 39/327 (11%), Positives = 88/327 (26%), Gaps = 45/327 (13%) Query: 66 RFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP--SLISVGCAD 123 F V+ + + V++++ D + + +T + K + + P + I D Sbjct: 18 AFNSQRTEFVTTTATNQVELYE-QDGNGWKHARTFSDHDKIVTCVDWAPKSNRIVTCSQD 76 Query: 124 GTISIWR---QNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIA 180 ++ L + S E+ K+ + G ++V Sbjct: 77 RNAYVYEKRPDGTWKQTLVLLR------LNRAATFVRWSPNED-KFAVGSGARVISVCYF 129 Query: 181 SFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDL 240 + + ++S P + LL +G DR + + D+ Sbjct: 130 EQENDWWVSKHLK---------RPLRSTILSLDWHPNNVLLAAGCADRKAYVLSAYVRDV 180 Query: 241 IDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAAT 300 E L N W+ ++ + S L A Sbjct: 181 DAKPEASVWGSRLPFNTVCAEYPSG----------------GWVHAVGFSPSGNALAYAG 224 Query: 301 ADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGK 360 D+S+ + P + + S + + + + L + Sbjct: 225 HDSSVTIAYPSAPEQPPRALITVKLSQLPLRSLLWANESAIVA-AGYNYS--PILLQGNE 281 Query: 361 TGSWRMWATKDNIICDQRLGISGATKD 387 +G WA ++ T + Sbjct: 282 SG----WAHTRDLDAGTSKTSFTHTGN 304 Score = 39.5 bits (90), Expect = 0.006, Method: Composition-based stats. Identities = 27/166 (16%), Positives = 56/166 (33%), Gaps = 7/166 (4%) Query: 10 IFIGANKQTQVSD-IHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFV 68 F +K D K +IV + +++ L T VR+ Sbjct: 50 TFSDHDKIVTCVDWAPKSNRIVTCSQDRNAYVYEKRPDGTWKQTLVLLRLNRAATFVRWS 109 Query: 69 PDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQH-YSKTIVALSALPS--LISVGCADGT 125 P+ D S + + F + + ++ TI++L P+ L++ GCAD Sbjct: 110 PNEDKFAVGSGARVISVCYFEQENDWWVSKHLKRPLRSTILSLDWHPNNVLLAAGCADRK 169 Query: 126 ISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIG 171 + +++ + + F +C ++ A+G Sbjct: 170 AYVLSAYVRDVDAKPEASVWGSRLPFNTVCAEY---PSGGWVHAVG 212 Score = 38.7 bits (88), Expect = 0.009, Method: Composition-based stats. Identities = 31/215 (14%), Positives = 71/215 (33%), Gaps = 27/215 (12%) Query: 244 SEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADT 303 + + ++ +T + Q ++ ++ G HD ++ + W +++ + D Sbjct: 20 NSQRTEFVTTTATNQ--VELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSNRIVTCSQDR 77 Query: 304 SLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGS 363 + V+E G W +L L ++ + ++ + Sbjct: 78 NAYVYEKRPD-GTWKQTLVLLRLNRAATFVRWSPNEDKFAVGSGARVISVCYFEQEND-- 134 Query: 364 WRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRK 423 W ++ R + + W P+ L A D+ + + ++ D K Sbjct: 135 ---WWVSKHLKRPLR-------STILSLDWHPNNVLLAAGCADRKAYVLSAYVRDVDA-K 183 Query: 424 REIATWHEFSRPQIHGYDMICVETVTDTRFVSGGD 458 E + W SR + +C E + SGG Sbjct: 184 PEASVWG--SRLPFNT---VCAE------YPSGGW 207 >5MC6-j nrPDB Length = 397 Score = 54.9 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 48/340 (14%), Positives = 103/340 (30%), Gaps = 57/340 (16%) Query: 56 KGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF-----TDYSHLQCIQTI----QHYSKT 106 K H+A++ V + F VS S D ++K+W + + H+ Sbjct: 13 KAHDADIFSV--SACNSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHVDV 70 Query: 107 IVALSALPS---LISVGCADGTISIWRQNIQNDEFGLAHE------FTIKKGFFYPLCLS 157 + A+ L++ G + +R +++ + E +KK F+ L Sbjct: 71 LQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFWALKWG 130 Query: 158 LSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRV----VAELEGH-EDWVKSLAFRH 212 S + L +I F + EL+G E + F Sbjct: 131 ASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPSQFAT 190 Query: 213 QETPGDY-LLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGI 271 + L+ +G + +++ + + + E + ++ + + I Sbjct: 191 SVDISERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSLLAI 250 Query: 272 NFEALIMG-------------------------------HDDWISSLQWHESRLQLLAAT 300 ++ G H W+ SL +++S L +A Sbjct: 251 AHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGETLCSAG 310 Query: 301 ADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGG 340 D L W+ I ++ ++ + A G Sbjct: 311 WDGKLRFWDVKTKERITTLNMHCDDIEIEEDILAVDEHGD 350 Score = 53.4 bits (126), Expect = 3e-07, Method: Composition-based stats. Identities = 49/319 (15%), Positives = 97/319 (30%), Gaps = 45/319 (14%) Query: 96 CIQTIQHYSKTIVALSALPSLISVGCADGTISIWR---QNIQNDEFGLAHEFTIKKGFFY 152 + + I ++SA S DG + +W + +N + F K G + Sbjct: 8 TANAGKAHDADIFSVSACNSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHH 67 Query: 153 PLCLSLSKVEEKK-YLLAIGGTNVNVFIASFILSDSGIEKC-----RVVAELEGHEDWVK 206 L + + + L+A + ++ D + + ++++ H W Sbjct: 68 VDVLQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFWAL 127 Query: 207 SLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNK--------- 257 + L+ + + +W+ +S + TL Sbjct: 128 KWGASNDRLLSHRLVATDVK-GTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPS 186 Query: 258 QYKFQID---------------------DELRVGINFEAL--IMGHDDWISSLQWHESRL 294 Q+ +D LR NFE+ ++ + + I S+++ Sbjct: 187 QFATSVDISERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGS 246 Query: 295 QLLAATADTSLMVWEPDETS-GIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMD 353 L A S ET G + SL + SS+ + S + L F + Sbjct: 247 LLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSS-WVMSLSFNDSG-E 304 Query: 354 FFLTNGKTGSWRMWATKDN 372 + G G R W K Sbjct: 305 TLCSAGWDGKLRFWDVKTK 323 Score = 43.7 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 9/64 (14%), Positives = 22/64 (34%), Gaps = 3/64 (4%) Query: 58 HEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHY---SKTIVALSALP 114 H + V + F + + SA D ++ W + + + I+A+ Sbjct: 290 HSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERITTLNMHCDDIEIEEDILAVDEHG 349 Query: 115 SLIS 118 ++ Sbjct: 350 DSLA 353 Score = 37.2 bits (84), Expect = 0.029, Method: Composition-based stats. Identities = 23/100 (23%), Positives = 36/100 (36%), Gaps = 14/100 (14%) Query: 560 EITCLDISPDQKLIASACRSNNVQNAVIRIFSTE-NWLEIKPALPFHSLT---------- 608 I + SP L+A A SN+ I ++ TE ++P HS Sbjct: 235 SIRSVKFSPQGSLLAIAHDSNSFG--CITLYETEFGERIGSLSVPTHSSQASLGEFAHSS 292 Query: 609 -ITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFK 647 + L F+ G+ L S D K W+ ++ L Sbjct: 293 WVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERITTLNMH 332 Score = 33.7 bits (75), Expect = 0.33, Method: Composition-based stats. Identities = 25/135 (18%), Positives = 46/135 (34%), Gaps = 10/135 (7%) Query: 562 TCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFL 621 T +DIS LIA+ + VQ + + E + ++ +S +I +KFS G L Sbjct: 190 TSVDISERG-LIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSLL 248 Query: 622 LSVCRDRK---WALWERNMEDNTFELRFKNEKPHTRI------IWDADWAPLEFGNVFVT 672 L+E + L + W + + G + Sbjct: 249 AIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGETLCS 308 Query: 673 ASRDKTVKVWRHQKE 687 A D ++ W + + Sbjct: 309 AGWDGKLRFWDVKTK 323 >5WLC-LH nrPDB Length = 896 Score = 54.5 bits (129), Expect = 2e-07, Method: Composition-based stats. Identities = 47/366 (12%), Positives = 121/366 (33%), Gaps = 34/366 (9%) Query: 52 YATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALS 111 LK H V + F D +++S + + +W+ + Q + + L Sbjct: 290 IRLLKWHIDSVLSLSFSHDGSYLLSGGWEKVMSLWQLET-NSQQFLPRLNGIIIDCQVLG 348 Query: 112 ALPSLISVGCADGTISIWRQNIQNDEFGL---AHEFTIKKGFFYPLCLSLSKVEEKKYLL 168 + S+ + + N +D L A + T K PL + S ++ + + Sbjct: 349 PQGNYYSL-----ILQMTENNSNSDYQFLLLNASDLTSKLSINGPLPVFNSTIKHIQQPI 403 Query: 169 AIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDR 228 + T + I S + +++ +D+ ++ + S Sbjct: 404 SAMNTKNSNSITSLN-HSKKKQSRKLIKSRR--QDFTTNVEINPINKNLYFPHISA---- 456 Query: 229 YIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQ 288 ++++ N+ ++ S + +++ + D + + F G ++ Sbjct: 457 -VQIFDFYKNEQVNYQYLTSGVNNSMGKVRFELNLQDPIITDLKFTK--DGQWMITYEIE 513 Query: 289 WHESRLQLLAATADTS--LMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLW 346 + + L ++ D + L W ++ W ++ ++ G S + Sbjct: 514 YPPND---LLSSKDLTHILKFWTKNDNETNWNLKTKV--INPHGISVPITKILPSPRSVN 568 Query: 347 FTHERMDFFLTNGKTGSWRMW--ATKDNIICDQRLGIS--GATKDVTDIAWSPSGEYLLA 402 + LT G + W + ++ C +++ + + +AWS G + Sbjct: 569 NSQG----CLTADNNGGLKFWSFDSHESNWCLKKISLPNFNHFSNSVSLAWSQDGSLIFH 624 Query: 403 TSLDQT 408 D+ Sbjct: 625 GFDDKL 630 Score = 48.4 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 102/661 (15%), Positives = 219/661 (33%), Gaps = 111/661 (16%) Query: 153 PLCLSLSKVEEKKYLLAIGGTNVN-VFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFR 211 P +LS V K + + N + + + +E + V L+ + + S F Sbjct: 20 PALNNLSSVTGNKNIARLSQDQRNYIIPFNNQIKVYSVETRQCVKTLKFANNSLLSGIFL 79 Query: 212 HQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGI 271 +E + ++ +I + D+ +ED+ +T+ +N + ++ + ++ Sbjct: 80 QEEENNESIV------------KILLGDITVPQQEDAHLITVFTNNGHVIVLNYKGKLVE 127 Query: 272 NFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGA 331 + + + D + +H + T +P + + + S RL ++ A Sbjct: 128 SPKHFKISLADEKLANVFHSEGNYRILTTFK------DPSQKAHNSLQSYRLYALTFDDA 181 Query: 332 STATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDI 391 + + + +NGK + + + + D ++ Sbjct: 182 KKQF----EVAHQAEWHNVILSNISSNGKLLAHMCKDVSTKDHEHKSISVVSLFDDSVNL 237 Query: 392 AW-------------SPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQI- 437 ++ S + Y+ + ++D + A G + + + QI Sbjct: 238 SFPLGSILSSQTQSLSYNTRYVSSMAIDNMGQQLAV------GFASGVISIVSLADLQIR 291 Query: 438 ----HGYDMICVE-TVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDS 492 H ++ + + + +SGG EK++ + L L + GI + + P Sbjct: 292 LLKWHIDSVLSLSFSHDGSYLLSGGWEKVMSLWQLETNSQQFLPRLNGIIIDCQVLGPQG 351 Query: 493 ATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVE 552 L + E+++N D + D+T LS+ P+ + +H+ P Sbjct: 352 N---YYSLILQMTENNSNSDYQFLL---LNASDLTSKLSINGPLPVFNSTIKHIQQPISA 405 Query: 553 KLYGHGFEITCLDISP---DQKLIASACRS-------NNVQNAV-------IRIFSTENW 595 + IT L+ S +KLI S + N + + ++IF Sbjct: 406 MNTKNSNSITSLNHSKKKQSRKLIKSRRQDFTTNVEINPINKNLYFPHISAVQIFDFYKN 465 Query: 596 LE----------------IKPALPFHSLTITRLKFSKDGKF-------------LLSVCR 626 + ++ L IT LKF+KDG++ L S Sbjct: 466 EQVNYQYLTSGVNNSMGKVRFELNLQDPIITDLKFTKDGQWMITYEIEYPPNDLLSSKDL 525 Query: 627 DRKWALWERNMEDNTFELRFKNEKPH-TRIIWDADWAPLEFGNV---FVTASRDKTVKVW 682 W +N + + L+ K PH + N +TA + +K W Sbjct: 526 THILKFWTKNDNETNWNLKTKVINPHGISVPITKILPSPRSVNNSQGCLTADNNGGLKFW 585 Query: 683 ---RHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKF 739 H+ + + H +++ ++ LI G ++ L T KF Sbjct: 586 SFDSHESNWCLKKISLPNFNHFSNSVSLAW----SQDGSLIFHGFDDKLQILDFDTFKKF 641 Query: 740 E 740 E Sbjct: 642 E 642 Score = 41.0 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 29/156 (18%), Positives = 61/156 (39%), Gaps = 14/156 (8%) Query: 92 SHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFF 151 + + ++ + +S+ L++ C D +S ++ + ++ F Sbjct: 183 KQFEVAHQAEWHNVILSNISSNGKLLAHMCKD--VSTKDHEHKSISVVSLFDDSVNLSFP 240 Query: 152 YPLCLSL---SKVEEKKYLLAIGGTNV----NVFIASFILSDSGIEKCRVVAELEGHEDW 204 LS S +Y+ ++ N+ V AS ++S + + + L+ H D Sbjct: 241 LGSILSSQTQSLSYNTRYVSSMAIDNMGQQLAVGFASGVISIVSLADLQ-IRLLKWHIDS 299 Query: 205 VKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDL 240 V SL+F H L SG ++ + LW++ N Sbjct: 300 VLSLSFSH----DGSYLLSGGWEKVMSLWQLETNSQ 331 Score = 37.6 bits (85), Expect = 0.020, Method: Composition-based stats. Identities = 19/109 (17%), Positives = 42/109 (38%), Gaps = 7/109 (6%) Query: 75 VSASEDHHVKIWKFTDYSHLQCIQ-----TIQHYSKTI-VALSALPSLISVGCADGTISI 128 ++A + +K W F + C++ H+S ++ +A S SLI G D + I Sbjct: 574 LTADNNGGLKFWSFDSHESNWCLKKISLPNFNHFSNSVSLAWSQDGSLIFHG-FDDKLQI 632 Query: 129 WRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNV 177 + L + T+ + ++ + + ++A T + Sbjct: 633 LDFDTFKKFESLENTKTVSEFTLDSEIQTVKLINDTNLIVATRTTLNAI 681 Score = 32.9 bits (73), Expect = 0.58, Method: Composition-based stats. Identities = 6/81 (7%), Positives = 23/81 (28%), Gaps = 5/81 (6%) Query: 23 IHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKG----HEAEVTCVRFVPDSDFMVSAS 78 ++ + + + W + + H + + + D + Sbjct: 567 VNNSQGCLTADNNGGLKFWSFDSHESNWCLKKISLPNFNHFSNSVSLAWSQDGSLIF-HG 625 Query: 79 EDHHVKIWKFTDYSHLQCIQT 99 D ++I F + + ++ Sbjct: 626 FDDKLQILDFDTFKKFESLEN 646 >5M89-A nrPDB Length = 329 Score = 54.1 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 35/205 (17%), Positives = 68/205 (33%), Gaps = 34/205 (16%) Query: 25 KVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVK 84 K+V A + ++D + AT + H VT + P + S D Sbjct: 101 TGTKVVIGTAKGWVKVYDAGRES-----ATFQTHAGPVTGLAVHPGGRILASVGVDKSFV 155 Query: 85 IWKFTDYSHLQCIQTIQHYS-KTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHE 143 + + + Y+ + + P DG +++ Q + H Sbjct: 156 FYDLETGE-----RVARGYADAALTTCAFHP--------DG--NLFAAGTQTGHILVFHT 200 Query: 144 FTIKKGFFYPL---CLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEG 200 T+++ +PL +L+ E + A G +V I S + V EL+ Sbjct: 201 TTLEQAESFPLGTPIQALAFSENGFWFAATGKGTSSVTIFDLRKSGAAAA----VKELQ- 255 Query: 201 HEDWVKSLAFRHQETPGDYLLCSGS 225 V S+++ + L +G Sbjct: 256 -TGEVLSISWDYT----GQYLATGG 275 Score = 41.4 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 33/210 (15%), Positives = 61/210 (29%), Gaps = 32/210 (15%) Query: 224 GSQDRYIRLWRIRIN--DLIDDSEEDSKKLTLLSNKQYKFQIDDELRV--GINFEALIMG 279 G D + ++ + N + D E K ++V A Sbjct: 69 GGLDGKLDIYSVVANKVERTLDIGEPVTATEWTGTKVVIGTAKGWVKVYDAGRESATFQT 128 Query: 280 HDDWISSLQWHESRLQLLAATADTSLMVWEPDETS---------GIWVCSLRLGEMSSKG 330 H ++ L H L + D S + ++ + + C+ + + Sbjct: 129 HAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGERVARGYADAALTTCAFH-PDGNLFA 187 Query: 331 ASTATGSS----------------GGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNII 374 A T TG G L F+ F T T S ++ + + Sbjct: 188 AGTQTGHILVFHTTTLEQAESFPLGTPIQALAFSENGFWFAATGKGTSSVTIFDLRKSGA 247 Query: 375 CDQRLGISGATKDVTDIAWSPSGEYLLATS 404 + T +V I+W +G+YL Sbjct: 248 AAAVKEL--QTGEVLSISWDYTGQYLATGG 275 Score = 32.9 bits (73), Expect = 0.50, Method: Composition-based stats. Identities = 19/112 (16%), Positives = 37/112 (33%), Gaps = 9/112 (8%) Query: 589 IFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKN 648 + H+ +T L G+ L SV D+ + ++ + R Sbjct: 113 WVKVYDAGRESATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGERV--ARGYA 170 Query: 649 EKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQK-EPADDYVLEASIK 699 + T A GN+F ++ + V+ E A+ + L I+ Sbjct: 171 DAALTTC------AFHPDGNLFAAGTQTGHILVFHTTTLEQAESFPLGTPIQ 216 Score = 31.0 bits (68), Expect = 2.2, Method: Composition-based stats. Identities = 29/217 (13%), Positives = 60/217 (27%), Gaps = 26/217 (11%) Query: 550 EVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTI 609 E H +T L + P +++AS + + + E + Sbjct: 122 ESATFQTHAGPVTGLAVHPGGRILASVGVDKSFV--FYDLETGERVARGYA-----DAAL 174 Query: 610 TRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNV 669 T F DG + + ++ + + W Sbjct: 175 TTCAFHPDGNLFAAGTQTGHILVFHTTTLEQAESFPLGTPIQALAFSENGFW-------F 227 Query: 670 FVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEI 729 T +V ++ +K A V E T V +IS + + L + G + Sbjct: 228 AATGKGTSSVTIFDLRKSGAAAAVKEL---QTGEVLSISWDYTG---QYLATGGGTGVTV 281 Query: 730 YLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRN 766 +Y+ K E + + ++W + Sbjct: 282 QMYT----KATKSWS--EPVRLGMPVVGVKWGGEAKR 312 >3EI3-B nrPDB Length = 383 Score = 53.4 bits (126), Expect = 4e-07, Method: Composition-based stats. Identities = 27/186 (14%), Positives = 62/186 (33%), Gaps = 10/186 (5%) Query: 54 TLKGHEAEVTCVRFVPDSDFM-VSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSA 112 K H+A+VT F P D++ ++S D VK+W + + K + A Sbjct: 199 KEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNAAYF 258 Query: 113 LP---SLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLA 169 P + + I ++ + + + F + + + ++A Sbjct: 259 NPTDSTKLLTTDQRNEIRVYSSYDWSKPDQII--IHPHRQFQHLTPIKATWHPMYDLIVA 316 Query: 170 IGGTNVNVFIAS-FILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDR 228 + + + + +V +L + + ++ +P +L SG Sbjct: 317 GRYPDDQLLLNDKRTIDIYDANSGGLVHQLR--DPNAAGIISLNKFSPTGDVLASG-MGF 373 Query: 229 YIRLWR 234 I +W Sbjct: 374 NILIWN 379 Score = 40.7 bits (93), Expect = 0.003, Method: Composition-based stats. Identities = 31/244 (12%), Positives = 72/244 (29%), Gaps = 29/244 (11%) Query: 187 SGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWR--IRINDLIDDS 244 ++ ++ + V SL + + GS+ I LW ++ Sbjct: 58 RSLKSYKLHRTASPFDRRVTSLEWHPTHPTT---VAVGSKGGDIILWDYDVQNKTSFIQG 114 Query: 245 EEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTS 304 +T + Q+ + + + + S +Q+ A T S Sbjct: 115 MGPGDAITGMKFNQF-----------NTNQLFVSSIRGATTLRDFSGSVIQVFAKTD--S 161 Query: 305 LMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGF--------WSCLWFTHERMDFFL 356 W + L G+ + + F + F R D+ + Sbjct: 162 WDYWYCCVDVSVSRQMLATGDSTGRLLLLGLDGHEIFKEKLHKAKVTHAEFN-PRCDWLM 220 Query: 357 -TNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSP-SGEYLLATSLDQTTRLFAP 414 T+ + ++W ++ + + K V ++P LL T R+++ Sbjct: 221 ATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNAAYFNPTDSTKLLTTDQRNEIRVYSS 280 Query: 415 WIYD 418 + + Sbjct: 281 YDWS 284 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 35/251 (13%), Positives = 78/251 (31%), Gaps = 67/251 (26%) Query: 92 SHLQCIQTIQHYSKTIVALSALPS---LISVGCADGTISIWRQNIQNDEFGL------AH 142 + +T + + + +L P+ ++VG G I +W ++QN + Sbjct: 61 KSYKLHRTASPFDRRVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDA 120 Query: 143 EFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVF----IASFILSDSGIE-KCRVVAE 197 +K F L +S + L G+ + VF + + +++A Sbjct: 121 ITGMKFNQFNTNQLFVSSIRGATTLRDFSGSVIQVFAKTDSWDYWYCCVDVSVSRQMLAT 180 Query: 198 LEG-------------------HEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRIN 238 + H+ V F + D+L+ + S D ++LW +R Sbjct: 181 GDSTGRLLLLGLDGHEIFKEKLHKAKVTHAEFNPRC---DWLMATSSVDATVKLWDLRN- 236 Query: 239 DLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHE-SRLQLL 297 I D ++ H+ +++ ++ +LL Sbjct: 237 --IKDKNSYIAEMP---------------------------HEKPVNAAYFNPTDSTKLL 267 Query: 298 AATADTSLMVW 308 + V+ Sbjct: 268 TTDQRNEIRVY 278 Score = 34.5 bits (77), Expect = 0.18, Method: Composition-based stats. Identities = 21/83 (25%), Positives = 34/83 (40%), Gaps = 3/83 (3%) Query: 648 NEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAI 707 EK H + A++ P + T+S D TVK+W + D A + H K V A Sbjct: 199 KEKLHKAKVTHAEFNP-RCDWLMATSSVDATVKLWDLR-NIKDKNSYIAEMPHEKPVNAA 256 Query: 708 SIHDSMIREKILISVGLENGEIY 730 + + K+L + +Y Sbjct: 257 YFNPTDS-TKLLTTDQRNEIRVY 278 >5AMS-A nrPDB Length = 431 Score = 50.7 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 31/205 (15%), Positives = 63/205 (30%), Gaps = 8/205 (3%) Query: 31 AFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTD 90 G LW TL G+ V F + F+V+A V + Sbjct: 82 TGGGDNLAHLW-TSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHMGQK 140 Query: 91 YSHLQCIQTIQHYSKTIVALSALPSL---ISVGCADGTISIWRQNIQNDEFGLAHEFTIK 147 + + + IV L P++ + G DG++ ++ N Q+ + Sbjct: 141 GGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVH 200 Query: 148 KGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKS 207 + + E L + + + + + AE++G E S Sbjct: 201 QQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFKITQ--AEIKGLEAPWIS 258 Query: 208 LAFRHQETPGDY--LLCSGSQDRYI 230 L+ + ++ GS + + Sbjct: 259 LSLAPETLTKGNSGVVACGSNNGLL 283 Score = 45.7 bits (106), Expect = 8e-05, Method: Composition-based stats. Identities = 25/195 (12%), Positives = 55/195 (28%), Gaps = 28/195 (14%) Query: 58 HEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS-- 115 H V + P+ + + D+ +W + T+ Y +++++ S Sbjct: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQP-PKFAGTLTGYGESVISCSFTSEGG 122 Query: 116 LISVGCADGTISI---------WRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKY 166 + G + + W+ Q E + L Sbjct: 123 FLVTADMSGKVLVHMGQKGGAQWKLASQMQEVE--------------EIVWLKTHPTIAR 168 Query: 167 LLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQ 226 A G T+ +V+ D +E ++++ +D + L + S Sbjct: 169 TFAFGATDGSVWCYQINEQDGSLE--QLMSGFVHQQDCSMGEFINTDKGENTLELVTCSL 226 Query: 227 DRYIRLWRIRINDLI 241 D I W + Sbjct: 227 DSTIVAWNCFTGQQL 241 Score = 39.9 bits (91), Expect = 0.005, Method: Composition-based stats. Identities = 20/165 (12%), Positives = 57/165 (34%), Gaps = 9/165 (5%) Query: 557 HGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPA-LPFHSLTITRLKFS 615 H + + P+ L+ + N + ++++ + L + ++ F+ Sbjct: 64 HTDSVFAIGHHPNLPLVCTGGGDN-----LAHLWTSHSQPPKFAGTLTGYGESVISCSFT 118 Query: 616 KDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASR 675 +G FL++ K + ++L + ++ I+W + F + Sbjct: 119 SEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEE-IVWLKTHPTIART--FAFGAT 175 Query: 676 DKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILI 720 D +V ++ ++ L + H + + ++ E L Sbjct: 176 DGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLE 220 >6IYY-A nrPDB Length = 317 Score = 48.7 bits (114), Expect = 9e-06, Method: Composition-based stats. Identities = 23/156 (14%), Positives = 53/156 (33%), Gaps = 8/156 (5%) Query: 20 VSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASE 79 V + ++AF T + + + + HE ++C+ + +ASE Sbjct: 137 VLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPPVDIPAHEGVLSCIALNLQGTRIATASE 196 Query: 80 DHH-VKIWKFTDYSHLQCIQTIQHYSKTIVALSA--LPSLISVGCADGTISIWRQNIQND 136 ++I+ + +Q ++ + I ++ SLI V GT+ I+ Sbjct: 197 KGTLIRIFDTSSGHLIQELRRG-SQAANIYCINFNQDASLICVSSDHGTVHIFAAEDPKS 255 Query: 137 EFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGG 172 ++ F+ + C+ E + Sbjct: 256 KWS----FSKFQVPSGSPCICAFGTEPNAVIAICAD 287 >5TF2-A nrPDB Length = 407 Score = 46.0 bits (107), Expect = 6e-05, Method: Composition-based stats. Identities = 15/68 (22%), Positives = 32/68 (47%), Gaps = 2/68 (2%) Query: 65 VRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADG 124 V F D+ + + D +V++WK + + + + + AL L++VG D Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDL-ALGPDGKLVTVG-RDL 235 Query: 125 TISIWRQN 132 S+W+++ Sbjct: 236 KASVWQKD 243 Score = 46.0 bits (107), Expect = 7e-05, Method: Composition-based stats. Identities = 15/79 (18%), Positives = 24/79 (30%), Gaps = 4/79 (5%) Query: 8 EAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRF 67 + F Q V H + G + +W K HE E+ + Sbjct: 166 QTDFSSDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSLEK---VLEFKAHEGEIEDLAL 222 Query: 68 VPDSDFMVSASEDHHVKIW 86 PD +V+ D +W Sbjct: 223 GPDGK-LVTVGRDLKASVW 240 Score = 41.4 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 35/200 (17%), Positives = 75/200 (37%), Gaps = 30/200 (15%) Query: 217 GDYLLCSGSQDRYIRLWRIRINDLIDD---SEEDSKKLTLLSNKQYKFQIDDELRVGINF 273 + LL +G D Y+R+W++ + + + E + + L L + + VG + Sbjct: 183 DNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGKLVT-------VGRDL 235 Query: 274 EALIMGHDDWISSLQWHESRLQLLAA-TADTSLMVWE-PDETSGIWVCSLRLGEMSSK-- 329 +A + D ++ L W E+ + + + PD+ +G+ + ++++ + Sbjct: 236 KASVWQKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLFTVQIPHKRLRQP 295 Query: 330 ---GASTATGSS----------GGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICD 376 + GS+ SCL + F TGS ++ ++ C Sbjct: 296 PPCYLTAWDGSNFLPLRTKSCGHEVVSCLDVSESGT-FLGLGTVTGSVAIY-IAFSLQCL 353 Query: 377 QRLGISGATKDVTDIAWSPS 396 VTD+A+ P Sbjct: 354 Y-YVREAHGIVVTDVAFLPE 372 Score = 38.7 bits (88), Expect = 0.010, Method: Composition-based stats. Identities = 19/105 (18%), Positives = 33/105 (31%), Gaps = 7/105 (6%) Query: 310 PDETSGIWVCSLRLGEMSSKGASTATG--SSGGFWSCLWFTHERMDFFLTNGKTGSWRMW 367 P E E+ + SS + F H+ T G G R+W Sbjct: 141 PAEKKCGAETQHEGLELRVENLQAVQTDFSSDPLQKVVCFNHDNTL-LATGGTDGYVRVW 199 Query: 368 ATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLF 412 ++ L ++ D+A P G+ L+ D ++ Sbjct: 200 KVPS---LEKVLEFKAHEGEIEDLALGPDGK-LVTVGRDLKASVW 240 Score = 37.6 bits (85), Expect = 0.024, Method: Composition-based stats. Identities = 12/72 (16%), Positives = 26/72 (36%), Gaps = 8/72 (11%) Query: 107 IVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKY 166 +V + +L++ G DG + +W+ EF +G L+ + K Sbjct: 177 VVCFNHDNTLLATGGTDGYVRVWKV----PSLEKVLEFKAHEG----EIEDLALGPDGKL 228 Query: 167 LLAIGGTNVNVF 178 + +V+ Sbjct: 229 VTVGRDLKASVW 240 Score = 36.4 bits (82), Expect = 0.052, Method: Composition-based stats. Identities = 21/72 (29%), Positives = 34/72 (47%), Gaps = 7/72 (9%) Query: 566 ISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVC 625 + D L+A+ V+ ++ S E LE K H I L DGK L++V Sbjct: 180 FNHDNTLLATGGTDGYVRVW--KVPSLEKVLEFKA----HEGEIEDLALGPDGK-LVTVG 232 Query: 626 RDRKWALWERNM 637 RD K ++W+++ Sbjct: 233 RDLKASVWQKDQ 244 >5WLC-LS nrPDB Length = 594 Score = 45.7 bits (106), Expect = 8e-05, Method: Composition-based stats. Identities = 62/428 (14%), Positives = 128/428 (29%), Gaps = 62/428 (14%) Query: 13 GANKQTQVSDIHKVKKIVAFGAG-----KTIALWDPIEPNNKGVYATLKGHEAE--VTCV 65 G+N DI+ + KI++ L P + + + H + + + Sbjct: 196 GSNNVIN-GDINALTKILSTTYNYKDTLSNSKLLPPKKLDIVRLKDANASHPSHSAIQSL 254 Query: 66 RFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSL-------IS 118 F P +++ D ++I+ D + ++ I + SL I Sbjct: 255 SFHPSKPLLLTGGYDKTLRIYHI-DGKTNHLVTSLHLVGSPIQTCTFYTSLSNQNQQNIF 313 Query: 119 VGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVF 178 + W +++N L H T K F L E + N Sbjct: 314 TAGRRRYMHSWDLSLEN----LTHSQTAKIEKFS----RLYGHESTQRSF------ENFK 359 Query: 179 IASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRY--------- 229 +A S + V+ L+G+ W+ L + L + Sbjct: 360 VAHLQNSQTNSVHGIVL--LQGNNGWINIL-----HSTSGLWLMGCKIEGVITDFCIDYQ 412 Query: 230 -IRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQ 288 I + R + ++ + + L N + D+ VGI + G +LQ Sbjct: 413 PISRGKFRTILIAVNAYGEVWEFDLNKNGHVIRRWKDQGGVGITKIQVGGGTTTTCPALQ 472 Query: 289 WH--ESRLQLLAATADTSLMVWEPDETSGIWVCS--LRLGEMSSKGASTATGSSGGFWSC 344 + L + + +++ + + L ++++ ++ G Sbjct: 473 ISKIKQNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCM 532 Query: 345 LWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATS 404 + + + W T + VT +A+SPSG L + Sbjct: 533 ASRAVKDALRLVHLPSCSVFSNWPTSGTPLGK-----------VTSVAFSPSGGLLAVGN 581 Query: 405 LDQTTRLF 412 RL+ Sbjct: 582 EQGKVRLW 589 Score = 44.5 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 56/365 (15%), Positives = 113/365 (30%), Gaps = 54/365 (14%) Query: 322 RLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMW----ATKDNIICDQ 377 +L + K A+ + S S + H LT G + R++ T + Sbjct: 232 KLDIVRLKDANASHPSHSAIQSLSF--HPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLH 289 Query: 378 RLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYD------ASGRKREIATWHE 431 +G T + + + + + + + + A K HE Sbjct: 290 LVGSPIQTCTFYTSLSNQNQQNIFTAGRRRYMHSWDLSLENLTHSQTAKIEKFSRLYGHE 349 Query: 432 FSRPQIHGYDMICVE-----TVTDTRFVSG--GDEKILRS----FDLPKGVAGMLQKFVG 480 ++ + + ++ +V + G G IL S + + + G++ F Sbjct: 350 STQRSFENFKVAHLQNSQTNSVHGIVLLQGNNGWINILHSTSGLWLMGCKIEGVITDFC- 408 Query: 481 IQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDE-----EEEGGNKETPDITDPLSLLEC 535 I ++ S + + + E D N++ +++GG T + C Sbjct: 409 IDYQPISRGKFRTILIAVNAYGEVWEFDLNKNGHVIRRWKDQGGVGITKIQVGGGTTTTC 468 Query: 536 PPMEDQLQRHLLWPEVEKLYGH------------------------GFEITCLDISPDQK 571 P ++ + W V G I+ L SPD + Sbjct: 469 PALQISKIKQNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQ 528 Query: 572 LIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWA 631 ++ A R+ ++ + S + P +T + FS G L K Sbjct: 529 ILCMASRAVKDALRLVHLPSC-SVFSNWPTSGTPLGKVTSVAFSPSGGLLAVGNEQGKVR 587 Query: 632 LWERN 636 LW+ N Sbjct: 588 LWKLN 592 Score = 44.5 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 39/352 (11%), Positives = 99/352 (28%), Gaps = 51/352 (14%) Query: 9 AIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRF- 67 A + +S ++ G KT+ ++ N + +L + + F Sbjct: 243 ASHPSHSAIQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNH-LVTSLHLVGSPIQTCTFY 301 Query: 68 ----VPDSDFMVSASEDHHVKIWKF--TDYSHLQCIQTIQ---HYSKTIVALSALPSLIS 118 + + +A ++ W + +H Q + + Y S ++ Sbjct: 302 TSLSNQNQQNIFTAGRRRYMHSWDLSLENLTHSQTAKIEKFSRLYGHESTQRSFENFKVA 361 Query: 119 VGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFY----------PLCLSLSKVEEKKYLL 168 T S+ + G + G + C+ + K+ Sbjct: 362 HLQNSQTNSVHGIVLLQGNNGWINILHSTSGLWLMGCKIEGVITDFCIDYQPISRGKFRT 421 Query: 169 AIGGTNVNVFIASF-------ILSDSGIEKCRVVAELE-GHEDWVKSLAFRHQETPGDYL 220 + N + F ++ + + +++ G A + + + Sbjct: 422 ILIAVNAYGEVWEFDLNKNGHVIRRWKDQGGVGITKIQVGGGTTTTCPALQISKIKQNRW 481 Query: 221 LCSGSQDRYIRLWRIRINDLIDDSEEDSKKL----------TLLSNKQY----KFQIDDE 266 L GS+ ++ L+ R N + + L + Q + D Sbjct: 482 LAVGSESGFVNLYD-RNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAVKDA 540 Query: 267 LRVGINFEALIMGH-------DDWISSLQWHESRLQLLAATADTSLMVWEPD 311 LR+ + + ++S+ + S L + +W+ + Sbjct: 541 LRLVHLPSCSVFSNWPTSGTPLGKVTSVAFSPSGGLLAVGNEQGKVRLWKLN 592 Score = 37.2 bits (84), Expect = 0.029, Method: Composition-based stats. Identities = 31/204 (15%), Positives = 61/204 (29%), Gaps = 26/204 (12%) Query: 41 WDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTI 100 + PI EV + H ++ WK + IQ Sbjct: 411 YQPISRGKFRTILIAVNAYGEVWEFDLNKNG---------HVIRRWKDQGGVGITKIQVG 461 Query: 101 QHYSKTIVALS----ALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCL 156 + T AL ++VG G ++++ +N + + L Sbjct: 462 GGTTTTCPALQISKIKQNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNL 521 Query: 157 SLSKVEEKKYLLAIGGTN--VNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQE 214 S + + + + V + S + + + + V S+AF Sbjct: 522 QFSPDGQILCMASRAVKDALRLVHLPSCSVFSNWPTSGTPLGK-------VTSVAFS--- 571 Query: 215 TPGDYLLCSGSQDRYIRLWRIRIN 238 P LL G++ +RLW++ Sbjct: 572 -PSGGLLAVGNEQGKVRLWKLNHY 594 >5WLC-LW nrPDB Length = 554 Score = 44.9 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 17/90 (18%), Positives = 34/90 (37%), Gaps = 10/90 (11%) Query: 37 TIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQC 96 T++LW P P + +G V + +M + D +KIW ++ L Sbjct: 255 TVSLWSPSMPEPLVKLLSARG---PVNSIAIDRSGYYMATTGADRSMKIWDIRNFKQLHS 311 Query: 97 IQTIQHYSKTI-------VALSALPSLISV 119 ++++ + +ALS P + Sbjct: 312 VESLPTPGTNVSISDTGLLALSRGPHVTLW 341 Score = 41.4 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 30/235 (12%), Positives = 78/235 (33%), Gaps = 29/235 (12%) Query: 65 VRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADG 124 + F+P +V+A E +K + + ++T + + +++ +G ++G Sbjct: 196 LDFLPYHYLLVTAGETGWLKYHDVSTGQLVSELRTKAGPTMAMAQNPWN-AVMHLGHSNG 254 Query: 125 TISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFIL 184 T+S+W ++ L ++ Y +A G + ++ I Sbjct: 255 TVSLWSPSMPEPLVKLLSARGPVNSI---------AIDRSGYYMATTGADRSMKIW---- 301 Query: 185 SDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW----RIRINDL 240 I + + +E +++ L + S+ ++ LW ++ + Sbjct: 302 ---DIRNFKQLHSVESLPTPGTNVSISDTG------LLALSRGPHVTLWKDALKLSGDSK 352 Query: 241 IDDSEEDSKKLTLLSNKQYKFQIDDELRVGINF--EALIMGHDDWISSLQWHESR 293 + F + +G + L +GH I++L + Sbjct: 353 PCFGSMGGNPHRNTPYMSHLFAGNKVENLGFVPFEDLLGVGHQTGITNLIVPGAG 407 Score = 32.9 bits (73), Expect = 0.60, Method: Composition-based stats. Identities = 12/77 (15%), Positives = 24/77 (31%), Gaps = 5/77 (6%) Query: 11 FIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPD 70 ++ + GA +++ +WD +L T V Sbjct: 271 LSARGPVNSIAIDRSGYYMATTGADRSMKIWDIRNFKQLHSVESL---PTPGTNVSISDT 327 Query: 71 SDFMVSASEDHHVKIWK 87 +++ S HV +WK Sbjct: 328 G--LLALSRGPHVTLWK 342 Score = 30.3 bits (66), Expect = 3.2, Method: Composition-based stats. Identities = 23/136 (16%), Positives = 45/136 (33%), Gaps = 14/136 (10%) Query: 550 EVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTI 609 E+ +L H E LD P L+ +A + ++ + + L K Sbjct: 183 ELHRLKQH-IEARHLDFLPYHYLLVTAGETGWLKYHDVSTGQLVSELRTKAGP------T 235 Query: 610 TRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNV 669 + + + + +LW +M + +L P I D G Sbjct: 236 MAMAQNPWNAVMHLGHSNGTVSLWSPSMPEPLVKLLSAR-GPVNSIAID------RSGYY 288 Query: 670 FVTASRDKTVKVWRHQ 685 T D+++K+W + Sbjct: 289 MATTGADRSMKIWDIR 304 >2I3T-A nrPDB Length = 341 Score = 44.9 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 33/302 (10%), Positives = 85/302 (28%), Gaps = 31/302 (10%) Query: 15 NKQTQVSDIHKVKKIVAFGAGKTIALWDP-IEPNNKGVYATLKGHEAEVTCVRFVPDSDF 73 + + + I ++ ++ ++ I+ N + +L+ ++ + C F+ ++D Sbjct: 12 DYISDIKIIPSKSLLLITSWDGSLTVYKFDIQAKNVDLLQSLR-YKHPLLCCNFIDNTDL 70 Query: 74 -MVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQN 132 + + + Q + + + DG I + Sbjct: 71 QIYVGTVQGEILKVDLIGSPSFQALTNNEANLGICRICKYGDDKLIAASWDGLIEVIDPR 130 Query: 133 IQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKC 192 D ++ + L +G N V L + Sbjct: 131 NYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSR---LIVGMNNSQVQWFRLPLCEDDNGTI 187 Query: 193 RVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLT 252 E G + ++ +A +E G S D + + + DD +D Sbjct: 188 ----EESGLKYQIRDVALLPKEQEG---YACSSIDGRVAV------EFFDDQGDDYNSSK 234 Query: 253 LLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDE 312 + + ++ + D ++S+++ L A +D + W Sbjct: 235 RFAFRCHRLNLKDTNLAYP------------VNSIEFSPRHKFLYTAGSDGIISCWNLQT 282 Query: 313 TS 314 Sbjct: 283 RK 284 Score = 42.6 bits (98), Expect = 7e-04, Method: Composition-based stats. Identities = 29/213 (13%), Positives = 69/213 (32%), Gaps = 20/213 (9%) Query: 74 MVSASEDHHVKIWKFTDYSHLQC-IQTIQHYSKTIV----ALSALPSLISVGCADGTISI 128 +++AS D +++ +Y ++ + + + + S + VG + + Sbjct: 115 LIAASWDGLIEVIDPRNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVGMNNSQVQW 174 Query: 129 WRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSG 188 +R + D+ G E +K ++ + +++ A + V + F Sbjct: 175 FRLPLCEDDNGTIEESGLKY-----QIRDVALLPKEQEGYACSSIDGRVAVEFFDDQGDD 229 Query: 189 IEKCRVVAELEGHEDWVKSLAFRHQE-----TPGDYLLCSGSQDRYIRLWRIRINDLIDD 243 + A H +K + +P L + D I W ++ I + Sbjct: 230 YNSSKRFA-FRCHRLNLKDTNLAYPVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKN 288 Query: 244 ----SEEDSKKLTLLSNKQYKFQIDDELRVGIN 272 +E+ K+ N DD + Sbjct: 289 FAKFNEDSVVKIACSDNILCLATSDDTFKTNAA 321 Score = 41.0 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 10/68 (14%), Positives = 25/68 (36%), Gaps = 2/68 (2%) Query: 60 AEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISV 119 V + F P F+ +A D + W ++ ++V ++ +++ + Sbjct: 252 YPVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKNFAKFN--EDSVVKIACSDNILCL 309 Query: 120 GCADGTIS 127 +D T Sbjct: 310 ATSDDTFK 317 >3DW8-B nrPDB Length = 447 Score = 44.9 bits (104), Expect = 2e-04, Method: Composition-based stats. Identities = 46/340 (13%), Positives = 101/340 (29%), Gaps = 68/340 (20%) Query: 25 KVKKIVAFGAGKTIALWDPIEPN----------------NKGVYATLK------------ 56 + + KTI LW E + + TL+ Sbjct: 106 NAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVE 165 Query: 57 ---------GHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFT-DYSHLQCIQ----TIQH 102 H + + D + +SA +D + +W + ++ Sbjct: 166 ASPRRIFANAHTYHINSISINSDYETYLSA-DDLRINLWHLEITDRSFNIVDIKPANMEE 224 Query: 103 YSKTIVALSALPSLISV---GCADGTISIWRQNI-----QNDEFGLAHEFTIKKGFFYPL 154 ++ I A P+ + + GTI + ++ + E + FF + Sbjct: 225 LTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEI 284 Query: 155 CLSLSKVE---EKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGH--EDWVKSLA 209 S+S V+ +Y++ ++V + + + +E +V L + Sbjct: 285 ISSISDVKFSHSGRYMMTRDY--LSVKVWDLNMENRPVETYQVHEYLRSKLCSLYENDCI 342 Query: 210 FRHQE---TPGDYLLCSGSQDRYIRLWRIRINDLID---DSEEDSKKLTLLSNKQYKFQI 263 F E D ++ +GS + + R++ I E + + L K Sbjct: 343 FDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGK 402 Query: 264 DDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADT 303 + + ++ + I WH + AT + Sbjct: 403 RKKDEISVDSLDF----NKKILHTAWHPKENIIAVATTNN 438 Score = 32.2 bits (71), Expect = 0.93, Method: Composition-based stats. Identities = 23/177 (12%), Positives = 62/177 (35%), Gaps = 23/177 (12%) Query: 608 TITRLKFSKDGKFLLSVCRDRKWALWERNM---------EDNTFELRFKNEKPHTRIIWD 658 I+ ++F+ G+ L + + + ++++ + F++ +P + Sbjct: 30 IISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKS 89 Query: 659 AD---------WAPLEFGNVFVTASRDKTVKVWRH--QKEPADDYVLEASIKHTKAVTAI 707 + W P + F+ ++ DKT+K+W+ + + + Y L+ + T + Sbjct: 90 LEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTV 149 Query: 708 SIH--DSMIREKILISVGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSH 762 + +++ ++Y + I E AD + W Sbjct: 150 TTLRVPVFRPMDLMVEASPRRIFANAHTYHINSIS-INSDYETYLSADDLRINLWHL 205 >4FHN-A nrPDB Length = 394 Score = 44.5 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 21/128 (16%), Positives = 42/128 (32%), Gaps = 11/128 (8%) Query: 14 ANKQTQVSDIHKVKKIVAF-GAGKTIALWDPIEPN--NKGVYATLKGHEAEVTCVR---- 66 + V+ +A T+ L + V GH V + Sbjct: 89 HDGDGNVNSSPVYSLFLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIADV 148 Query: 67 FVPDSDF----MVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCA 122 + D+ + S +D + IW+ TD + + ++ + P+ + VG Sbjct: 149 YSADNRLAEQVIASVGDDCTLIIWRLTDEGPILAGYPLSSPGISVQFRPSNPNQLIVGER 208 Query: 123 DGTISIWR 130 +G I I+ Sbjct: 209 NGNIRIFD 216 >4AV8-A nrPDB Length = 339 Score = 42.6 bits (98), Expect = 7e-04, Method: Composition-based stats. Identities = 19/146 (13%), Positives = 48/146 (32%), Gaps = 6/146 (4%) Query: 56 KGHEAEVTCVRFVPDSDFMVSASEDHH-VKIWKFTDYSHLQCIQTIQHYSKTI-VALSAL 113 K H V VR D + + S+D +++++ + ++ + + I + S Sbjct: 176 KAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWSPD 235 Query: 114 PSLISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGT 173 S ++V T+ ++ + + I +F + K ++ G Sbjct: 236 GSKLAVVSDKWTLHVFEVFNDAENKRHVLKDWINIKYFQSEWSICNF----KLKVSKGSN 291 Query: 174 NVNVFIASFILSDSGIEKCRVVAELE 199 + + S R+ + Sbjct: 292 DCKIAWISDTGLVIVWPNRRLADTFK 317 Score = 32.6 bits (72), Expect = 0.77, Method: Composition-based stats. Identities = 35/228 (15%), Positives = 68/228 (29%), Gaps = 12/228 (5%) Query: 217 GDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEAL 276 +Y+ ++ + +W I + D+ L ++++ ++ F Sbjct: 65 TNYIAFVSTKKELLHIWDDVKKQDITRVKLDAAVKDLFLSREFIVVSQGDVISIFKFGNP 124 Query: 277 IMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATG 336 + I E LL + + +L I V L+ G Sbjct: 125 WNKITEDIKFGGVCEFANGLLVYSNEFNL--------GQIHVTRLQTDAEQVVGKGVLVK 176 Query: 337 SSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPS 396 + + + D T + G+ DN + + + D+ WSP Sbjct: 177 AHANPVKMVRLNRKG-DMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWSPD 235 Query: 397 GEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMIC 444 G L S T +F + DA ++ + W Q IC Sbjct: 236 GSKLAVVSDKWTLHVFEVF-NDAENKRHVLKDWINIKYFQ--SEWSIC 280 Score = 31.8 bits (70), Expect = 1.2, Method: Composition-based stats. Identities = 13/57 (22%), Positives = 26/57 (45%), Gaps = 1/57 (1%) Query: 579 SNNVQNAVIRIFSTENWLEIKPALPFHSLT-ITRLKFSKDGKFLLSVCRDRKWALWE 634 + + +IR+F T+N + ++ T I +++S DG L V ++E Sbjct: 196 TCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWSPDGSKLAVVSDKWTLHVFE 252 >2VDU-B nrPDB Length = 450 Score = 40.7 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 35/244 (14%), Positives = 83/244 (34%), Gaps = 19/244 (7%) Query: 57 GHEAEVTCVRFVPDSD---FMVSASEDHHVKIWKFTDYSHLQCI---QTIQHYSKTIVAL 110 GH + +T V + DSD F++++ D H+KI + QC + + + + ++ Sbjct: 193 GHVSMLTDVHLIKDSDGHQFIITSDRDEHIKI-----SHYPQCFIVDKWLFGHKHFVSSI 247 Query: 111 SALPS-LISVGCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLA 169 L+ D I W + + IK E ++ Sbjct: 248 CCGKDYLLLSAGGDDKIFAWDWKTGKNLSTFDYNSLIKPYLNDQHLAPPRFQNENNDIIE 307 Query: 170 IGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRH-QETPGDYLLCSGSQDR 228 + + + + +E + + LE E LA + P + + S D Sbjct: 308 FAVSKI-IKSKNLPFVAFFVEATKCIIILEMSEKQKGDLALKQIITFPYNVISLSAHNDE 366 Query: 229 YIRLWRIRINDLIDDS-----EEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDW 283 + + + + + E + + + + N + + D + + ++ ++ + Sbjct: 367 FQVTLDNKESSGVQKNFAKFIEYNLNENSFVVNNEKSNEFDSAIIQSVQGDSNLVTKKEE 426 Query: 284 ISSL 287 I L Sbjct: 427 IYPL 430 Score = 38.3 bits (87), Expect = 0.014, Method: Composition-based stats. Identities = 21/100 (21%), Positives = 35/100 (35%), Gaps = 8/100 (8%) Query: 3 ECITPEAIFIGANKQTQVSDIHKV---KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHE 59 E T E I + T V I + I+ + I + P V L GH+ Sbjct: 184 EKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKI--SHYPQCFIVDKWLFGHK 241 Query: 60 AEVTCVRFVPDSDFMV-SASEDHHVKIWKFTDYSHLQCIQ 98 V+ + D+++ SA D + W + +L Sbjct: 242 HFVSSI--CCGKDYLLLSAGGDDKIFAWDWKTGKNLSTFD 279 >5LTD-A nrPDB Length = 525 Score = 39.5 bits (90), Expect = 0.006, Method: Composition-based stats. Identities = 17/113 (15%), Positives = 44/113 (38%), Gaps = 5/113 (4%) Query: 5 ITPEAIFIGANKQTQVSDIHKVKKIVAFGAGK--TIALWDPIEPNNKGVYATLKG-HEAE 61 + P ++ + K ++A + K I ++ +Y +G + + Sbjct: 212 LQPTSVIEAHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGI--KLYQFRRGTYPTK 269 Query: 62 VTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP 114 + + F PD+ F++++S V I++ + I++ ++ A P Sbjct: 270 IYSLAFSPDNRFVIASSATETVHIFRLGEEEAANTIKSANKKARLTKAQVPNP 322 Score = 37.2 bits (84), Expect = 0.031, Method: Composition-based stats. Identities = 23/160 (14%), Positives = 54/160 (33%), Gaps = 11/160 (6%) Query: 7 PEAIFIGANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVR 66 P + N QT+V+ +H + V G + ++D + ++ H + + Sbjct: 177 PSPQKLAPNPQTEVT-LHSNPQTVRNGD---VIIFDA---KTLQPTSVIEAHRTSLAAIA 229 Query: 67 FVPDSDFMVSASEDHH-VKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS--LISVGCAD 123 D + +AS+ ++++ L + Y I +L+ P + A Sbjct: 230 LSKDGLLLATASDKGTIIRVFSVATGIKLYQFRRGT-YPTKIYSLAFSPDNRFVIASSAT 288 Query: 124 GTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEE 163 T+ I+R + + + + L + Sbjct: 289 ETVHIFRLGEEEAANTIKSANKKARLTKAQVPNPLETSPD 328 Score = 31.0 bits (68), Expect = 1.9, Method: Composition-based stats. Identities = 35/173 (20%), Positives = 68/173 (39%), Gaps = 22/173 (12%) Query: 522 ETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPD-QKLIASACRSN 580 ETP ++P L+ P +L +P +KL +P+ Q + Sbjct: 154 ETP--SNPNGLIALSP--SSENNYLAYPSPQKL------------APNPQTEVTLHSNPQ 197 Query: 581 NVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDN 640 V+N + IF + L+ + H ++ + SKDG L + D+ + ++ Sbjct: 198 TVRNGDVIIFDAKT-LQPTSVIEAHRTSLAAIALSKDGLLLATAS-DKGTIIRVFSVATG 255 Query: 641 TFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYV 693 +F+ T+I A F + +S +TV ++R +E A + + Sbjct: 256 IKLYQFRRGTYPTKIYSLAFSPDNRF---VIASSATETVHIFRLGEEEAANTI 305 Score = 30.6 bits (67), Expect = 2.6, Method: Composition-based stats. Identities = 23/201 (11%), Positives = 69/201 (34%), Gaps = 21/201 (10%) Query: 228 RYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSL 287 R +++ + I + L + N++ + +E + + + H S Sbjct: 99 RRLKIINTKRQTTICELTFPGAILAVKLNRERLVVLLEETIYIYDINNMRLLHTIETPS- 157 Query: 288 QWHESRLQLLAATADTSLMVW------EPDETS----GIWVCSLRLGE------MSSKGA 331 + + L L+ +++ + + + P+ + ++R G+ + + Sbjct: 158 --NPNGLIALSPSSENNYLAYPSPQKLAPNPQTEVTLHSNPQTVRNGDVIIFDAKTLQPT 215 Query: 332 STATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDI 391 S + + ++ K R+++ I + + + Sbjct: 216 SVIEAHRTSLAAIALSKDGLLLATASD-KGTIIRVFSVATGIKL-YQFRRGTYPTKIYSL 273 Query: 392 AWSPSGEYLLATSLDQTTRLF 412 A+SP +++A+S +T +F Sbjct: 274 AFSPDNRFVIASSATETVHIF 294 >6CVZ-A nrPDB Length = 351 Score = 38.3 bits (87), Expect = 0.012, Method: Composition-based stats. Identities = 14/75 (18%), Positives = 30/75 (40%), Gaps = 2/75 (2%) Query: 58 HEAEVTCVRFVPDSD-FMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSL 116 H ++ + F ++SAS D+ +K+ + +Q + L + Sbjct: 73 HGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNAGRPVWSCCWCLDEA-NY 131 Query: 117 ISVGCADGTISIWRQ 131 I G A+G+I ++ Sbjct: 132 IYAGLANGSILVYDV 146 >5K1H-B nrPDB Length = 576 Score = 36.4 bits (82), Expect = 0.054, Method: Composition-based stats. Identities = 20/110 (18%), Positives = 32/110 (29%), Gaps = 13/110 (11%) Query: 29 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSAS--EDHH---- 82 +A + IALW H+ V + F P ++V+ S D Sbjct: 179 YLATFHQRGIALW---GGEKFKQIQRF-SHQG-VQLIDFSPCERYLVTFSPLMDTQDDPQ 233 Query: 83 -VKIWKFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQ 131 + IW + I S + D T+SI+ Sbjct: 234 AIIIWDILTGHKKRGFHCESSAHWPIFKWSHDGKFFARMTLD-TLSIYET 282 >3FGB-A nrPDB Length = 361 Score = 35.6 bits (80), Expect = 0.073, Method: Composition-based stats. Identities = 22/93 (23%), Positives = 37/93 (39%), Gaps = 2/93 (2%) Query: 566 ISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGKFLLSVC 625 ISPD K + ++ R A+ I EN + K + + +GK+LL C Sbjct: 258 ISPDGKFLYASNRLKADGLAIFSI-HPENGMLTKVGYQLTGIHPRNFIITPNGKYLLVAC 316 Query: 626 RDR-KWALWERNMEDNTFELRFKNEKPHTRIIW 657 RD ++ER+ + K+ K + Sbjct: 317 RDSNVIQVYERDTDTGLLTDIRKDIKVDKPVCI 349 >4YHC-A nrPDB Length = 468 Score = 35.3 bits (79), Expect = 0.11, Method: Composition-based stats. Identities = 18/155 (11%), Positives = 51/155 (32%), Gaps = 11/155 (7%) Query: 43 PIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQH 102 + + H+ ++ + + S D + +W + + + Sbjct: 14 TLHEEKFRIEPVPVHHQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLVLSK-EQ 72 Query: 103 YSKTIVALSALPSLISVG--CADGTISIWRQNIQNDEFGLAHEFTIK-----KGFFYPLC 155 +T+ A++ P V D +++ N+++ L H + K F+ P Sbjct: 73 MPRTLKAIALDPQGNYVSLFSKD---TLFILNVESPSLMLQHSYHSKPNSKLNVFWMPGT 129 Query: 156 LSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIE 190 + + + ++ + VF + + + I Sbjct: 130 HKDDEWKNFELVVVESSGEIQVFSLTIEIEGADIA 164 Score = 30.3 bits (66), Expect = 3.2, Method: Composition-based stats. Identities = 11/77 (14%), Positives = 25/77 (32%), Gaps = 6/77 (7%) Query: 557 HGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFH-SLTITRLKFS 615 H +I + +S + K AS + + ++ W T+ + Sbjct: 29 HQLDILKIAVSENYKTFASVG-----LDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIALD 83 Query: 616 KDGKFLLSVCRDRKWAL 632 G ++ +D + L Sbjct: 84 PQGNYVSLFSKDTLFIL 100 >4MHC-A nrPDB Length = 826 Score = 35.3 bits (79), Expect = 0.11, Method: Composition-based stats. Identities = 18/109 (16%), Positives = 34/109 (31%), Gaps = 9/109 (8%) Query: 79 EDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALPS---------LISVGCADGTISIW 129 D+ + +W + S CI I+H + + P+ LI D I Sbjct: 109 SDNKLILWNINNSSEYHCIDEIEHTILKVKLVKPSPNTFVSSVENLLIVATLFDIYILTI 168 Query: 130 RQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVF 178 N + E + + + + +S + VNV+ Sbjct: 169 SFNDRTHELNIFNTGLKVNVTGFNVSNIISYERTGQIFFTGATDGVNVW 217 >3JB9-S nrPDB Length = 488 Score = 34.1 bits (76), Expect = 0.27, Method: Composition-based stats. Identities = 21/142 (14%), Positives = 49/142 (34%), Gaps = 10/142 (7%) Query: 14 ANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDF 73 A T ++ VA + ++ N + H + V ++F + + Sbjct: 333 AQHITSLAVHPDGNLFVAGLENGELRFFETSSGNELTKFGP---HSSPVKTLQFGENGYW 389 Query: 74 M-VSASEDHHVKIWKFTDYSHLQCI---QTIQHYSKTIVA---LSALPSLISVGCADGTI 126 + V+ ++D + IW +Q I + S I + +S+ + V + Sbjct: 390 LVVTTNDDSDIFIWDLRKSELVQKIPLQTKVAAVSLDITSQLLVSSDGETLYVHIYVKSS 449 Query: 127 SIWRQNIQNDEFGLAHEFTIKK 148 WR Q +++ + + Sbjct: 450 KSWRCMSQTHVSSISNLVWLNE 471 >5GRS-A nrPDB Length = 396 Score = 34.1 bits (76), Expect = 0.27, Method: Composition-based stats. Identities = 18/155 (11%), Positives = 51/155 (32%), Gaps = 11/155 (7%) Query: 43 PIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQH 102 + + H+ ++ + + S D + +W + + + Sbjct: 14 TLHEEKFRIEPVPVHHQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLVLSK-EQ 72 Query: 103 YSKTIVALSALPSLISVG--CADGTISIWRQNIQNDEFGLAHEFTIK-----KGFFYPLC 155 +T+ A++ P V D +++ N+++ L H + K F+ P Sbjct: 73 MPRTLKAIALDPQGNYVSLFSKD---TLFILNVESPSLMLQHSYHCKPNSKLNVFWMPGT 129 Query: 156 LSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIE 190 + + + ++ + VF + + + I Sbjct: 130 HKDDEWKNFELVVVESSGEIQVFSLTIEIEGADIA 164 Score = 29.9 bits (65), Expect = 4.7, Method: Composition-based stats. Identities = 11/77 (14%), Positives = 25/77 (32%), Gaps = 6/77 (7%) Query: 557 HGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFH-SLTITRLKFS 615 H +I + +S + K AS + + ++ W T+ + Sbjct: 29 HQLDILKIAVSENYKTFASVG-----LDRCLVVWDLRQWCTKLVLSKEQMPRTLKAIALD 83 Query: 616 KDGKFLLSVCRDRKWAL 632 G ++ +D + L Sbjct: 84 PQGNYVSLFSKDTLFIL 100 >3T8I-A nrPDB Length = 306 Score = 33.7 bits (75), Expect = 0.30, Method: Composition-based stats. Identities = 24/148 (16%), Positives = 49/148 (33%), Gaps = 15/148 (10%) Query: 537 PMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWL 596 P + + H + + H E+ L ISP + + + +V V +I+ + Sbjct: 92 PNKRPEKEHAIDAILRLSKEHEGELEILAISPLTNIALAYLKDPSVVKRVKKIW-----I 146 Query: 597 EIKPALPFHSLTITRLKFSKD---GKFLLSVCRDRKWALWE-----RNMEDNTFELRFKN 648 ++ I F D K +L D WE ++ + +E K Sbjct: 147 MGGAFSKGNTTPIAEFNFWVDPEAAKIVLDAGFDITIVPWEVAEISGSLNERDWEYISKL 206 Query: 649 EKPHTRIIWDADWAPLEFG--NVFVTAS 674 + + + E+ N ++ S Sbjct: 207 NTKLSNFFINVNKTLKEYTTKNQGISGS 234 >5BPW-A nrPDB Length = 843 Score = 32.6 bits (72), Expect = 0.65, Method: Composition-based stats. Identities = 42/207 (20%), Positives = 73/207 (35%), Gaps = 10/207 (4%) Query: 542 LQRHLLWPEVEKLYGHGF--EITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIK 599 L+ +P + EI L SP + LIA A N ++ ++ + + Sbjct: 2 LRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALA---NTAGEVLLHRLASFHRVWSF 58 Query: 600 PALPFHSLTITRLKFSKDGKFLLSVCRD-RKWALWERNMEDNTFELRFKNEKPHTRIIWD 658 P +T L + DGK L D +K L + ++ E P + + W Sbjct: 59 PPNENTGKEVTCLAWRPDGKLLAFALADTKKIVLCDVEKPESLHSFSV--EAPVSCMHWM 116 Query: 659 ADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKI 718 F A D++ + +Y + I + I +R I Sbjct: 117 EVTVESSVLTSFYNA-EDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNI 175 Query: 719 LISVGLENGEIYLYSYTLGKFELITQL 745 L+ G +G I LY+Y + K +T + Sbjct: 176 LVLGG-SSGFIELYAYGMFKIARVTGI 201 >5BPT-A nrPDB Length = 741 Score = 32.2 bits (71), Expect = 0.93, Method: Composition-based stats. Identities = 37/190 (19%), Positives = 71/190 (37%), Gaps = 14/190 (7%) Query: 560 EITCLDISPDQKLIASACRSNNVQ-NAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDG 618 EI L SP + LIA ++ V + + I + P +T L + DG Sbjct: 15 EIIFLAWSPKRDLIALVNKAGEVLLHRLANIQRVWSL----PPNENTGKEVTCLAWRPDG 70 Query: 619 KFLLSVCRD-RKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDK 677 K L D +K L + ++ F E P + + W F A + Sbjct: 71 KILAFGLADTKKVILCDVEKPESLHS--FSLETPISCMQWMEVNVENSVLTSFYNAEDEA 128 Query: 678 TVKVWRHQKEPADDYVLEASIKH--TKAVTAISIHDSMIREKILISVGLENGEIYLYSYT 735 V + + P + + + + + D+ + +L G ++G+I +Y+Y Sbjct: 129 NVLLPKLPALPKNYTATAKIFSEEKSDEILKL-LGDARLNALVL---GGDSGQIEIYAYG 184 Query: 736 LGKFELITQL 745 + K I+++ Sbjct: 185 MYKIATISEV 194 >6N8P-A nrPDB Length = 979 Score = 29.9 bits (65), Expect = 4.2, Method: Composition-based stats. Identities = 9/56 (16%), Positives = 20/56 (35%), Gaps = 6/56 (10%) Query: 83 VKIWK------FTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQN 132 +K+W+ +H ++ ++ L+ G DGT+ W + Sbjct: 387 LKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGHEDGTVRFWDAS 442 >5CWW-B nrPDB Length = 595 Score = 29.9 bits (65), Expect = 5.0, Method: Composition-based stats. Identities = 7/36 (19%), Positives = 17/36 (47%), Gaps = 3/36 (8%) Query: 59 EAEVTCVRFVP---DSDFMVSASEDHHVKIWKFTDY 91 + V + P + +V+ +ED V++W+ + Sbjct: 172 RSAVVSAVWHPLGVNGHALVTVTEDAIVRVWELSTA 207 >5IXM-A nrPDB Length = 577 Score = 29.9 bits (65), Expect = 5.1, Method: Composition-based stats. Identities = 17/62 (27%), Positives = 26/62 (41%) Query: 252 TLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPD 311 SN ++F + + NF+A I H LQW LLA + T + W P+ Sbjct: 30 KFTSNNGFEFLLPYYWNIAPNFDATITPHYMERRGLQWQNEFRYLLAPGSGTMALDWLPN 89 Query: 312 ET 313 + Sbjct: 90 DR 91 >6GB2-BE nrPDB Length = 348 Score = 29.5 bits (64), Expect = 6.4, Method: Composition-based stats. Identities = 20/166 (12%), Positives = 42/166 (25%), Gaps = 15/166 (9%) Query: 555 YGHGFEITCLD--------ISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHS 606 H + L ++ ++IF+ IKP P ++ Sbjct: 136 ENHNGRMAALTVGGKTVSHFHKSASILEFYQELGLPPKQKVKIFNVTENAVIKPGTPLYA 195 Query: 607 LTITRLKFSKDGKFLLSVCRDRKWALW--ERNMEDNTFELRFKNEKPHTRIIWDADWAPL 664 ++ + W + + + + W Sbjct: 196 AHFRPGQYVDVTAKTIGKGFQGVMRRWGFKGQPATHGQTKTHRRPGAISTGDVARVWPGT 255 Query: 665 EFGNVFVTASRDKT---VKVWRHQKEPADDYVLEASIKHTKAVTAI 707 + + D+T +KVWR + YV + H + I Sbjct: 256 KMPGQL--GNIDRTAFGLKVWRINTKHNIIYVNGSVPGHKNCLVKI 299 >4CE4-E nrPDB Length = 399 Score = 29.5 bits (64), Expect = 6.5, Method: Composition-based stats. Identities = 20/166 (12%), Positives = 42/166 (25%), Gaps = 15/166 (9%) Query: 555 YGHGFEITCLD--------ISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHS 606 H + L ++ ++IF+ IKP P ++ Sbjct: 187 ENHNGRMAALTVGGKTVSHFHKSASILEFYQELGLPPKQKVKIFNVTENAVIKPGTPLYA 246 Query: 607 LTITRLKFSKDGKFLLSVCRDRKWALW--ERNMEDNTFELRFKNEKPHTRIIWDADWAPL 664 ++ + W + + + + W Sbjct: 247 AHFRPGQYVDVTAKTIGKGFQGVMRRWGFKGQPATHGQTKTHRRPGAISTGDVARVWPGT 306 Query: 665 EFGNVFVTASRDKT---VKVWRHQKEPADDYVLEASIKHTKAVTAI 707 + + D+T +KVWR + YV + H + I Sbjct: 307 KMPGQL--GNIDRTAFGLKVWRINTKHNIIYVNGSVPGHKNCLVKI 350 >1K3I-A nrPDB Length = 656 Score = 29.1 bits (63), Expect = 7.4, Method: Composition-based stats. Identities = 15/97 (15%), Positives = 33/97 (34%), Gaps = 4/97 (4%) Query: 310 PDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWAT 369 P G W ++ L + + A T +W ++ F + G W Sbjct: 171 PQPGLGRWGPTIDLPIVPAAAAIEPTSGR----VLMWSSYRNDAFGGSPGGITLTSSWDP 226 Query: 370 KDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLD 406 I+ D+ + ++ I+ +G+ ++ D Sbjct: 227 STGIVSDRTVTVTKHDMFCPGISMDGNGQIVVTGGND 263 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.308 0.115 0.296 Lambda K H 0.267 0.0353 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 27,223,821 Number of Sequences: 36641 Number of extensions: 1029662 Number of successful extensions: 8263 Number of sequences better than 10.0: 152 Number of HSP's better than 10.0 without gapping: 206 Number of HSP's successfully gapped in prelim test: 57 Number of HSP's that attempted gapping in prelim test: 2851 Number of HSP's gapped (non-prelim): 2142 length of query: 788 length of database: 10,336,785 effective HSP length: 105 effective length of query: 683 effective length of database: 6,489,480 effective search space: 4432314840 effective search space used: 4432314840 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 63 (29.1 bits)