BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P42841 (465 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 6EOJ-D nrPDB 976 0.0 5M25-A nrPDB 108 6e-24 2H9P-A nrPDB 107 1e-23 5MZH-A nrPDB 103 2e-22 5NNZ-B nrPDB 91 1e-18 6Q8F-A nrPDB 88 9e-18 6N9G-C nrPDB 87 2e-17 1VYH-C nrPDB 86 3e-17 6MZM-G nrPDB 82 6e-16 6HQA-B nrPDB 81 8e-16 6F3T-A nrPDB 81 9e-16 5UZ7-B nrPDB 80 3e-15 5Y88-O nrPDB 78 8e-15 3FM0-A nrPDB 77 1e-14 6ID0-T nrPDB 77 2e-14 5OPT-p nrPDB 77 2e-14 5FA5-B nrPDB 75 4e-14 6QX9-4B nrPDB 74 1e-13 5Z56-q nrPDB 70 1e-12 5WLC-LO nrPDB 70 1e-12 5I2T-A nrPDB 70 2e-12 3DM0-A nrPDB 70 2e-12 4V8M-A7 nrPDB 70 2e-12 5WYK-BB nrPDB 69 3e-12 4LG8-A nrPDB 69 3e-12 6G51-g nrPDB 69 5e-12 5OQL-d nrPDB 67 1e-11 4AEZ-A nrPDB 67 2e-11 5FL8-q nrPDB 66 3e-11 4V6W-Ag nrPDB 65 4e-11 4V7E-Bg nrPDB 65 7e-11 5WYJ-BC nrPDB 64 1e-10 6GMH-W nrPDB 64 1e-10 3ACP-A nrPDB 64 2e-10 2HES-X nrPDB 63 2e-10 5NZU-C nrPDB 62 4e-10 4BTS-AR nrPDB 62 7e-10 6QX9-5O nrPDB 60 2e-09 5L9T-R nrPDB 60 2e-09 5K1B-B nrPDB 59 3e-09 5GAN-H nrPDB 58 1e-08 3ODT-A nrPDB 57 2e-08 6HHQ-h nrPDB 56 3e-08 5G04-R nrPDB 56 3e-08 3JAP-g nrPDB 56 3e-08 4GGA-A nrPDB 55 9e-08 4G56-B nrPDB 55 9e-08 5WYJ-BE nrPDB 54 1e-07 5LCW-Q nrPDB 54 1e-07 5WBU-D nrPDB 54 1e-07 2YNP-A nrPDB 54 1e-07 3CFV-B nrPDB 54 2e-07 4J0W-A nrPDB 54 2e-07 6EMK-B nrPDB 53 2e-07 5FVM-C nrPDB 53 3e-07 3MKQ-A nrPDB 52 4e-07 5XYI-g nrPDB 52 4e-07 5OQL-J nrPDB 52 5e-07 4N14-A nrPDB 52 6e-07 5WLC-LJ nrPDB 50 1e-06 5OV3-A nrPDB 50 2e-06 5N4A-A nrPDB 50 2e-06 5OQL-X nrPDB 50 3e-06 3JB9-L nrPDB 49 4e-06 3F3P-A nrPDB 49 6e-06 4L9O-A nrPDB 49 6e-06 4U1E-I nrPDB 49 6e-06 5WLC-LU nrPDB 48 8e-06 4YCZ-A nrPDB 48 9e-06 6J6H-n nrPDB 48 1e-05 6BX3-A nrPDB 47 1e-05 4BZK-B nrPDB 47 2e-05 4OWR-A nrPDB 47 2e-05 3JRP-A nrPDB 47 2e-05 3JRO-A nrPDB 47 2e-05 5K0Y-T nrPDB 46 4e-05 5WJC-A nrPDB 46 4e-05 3JB9-g nrPDB 46 4e-05 5A9Q-0 nrPDB 46 4e-05 2PM9-A nrPDB 46 4e-05 5CXC-A nrPDB 45 5e-05 5YZG-W nrPDB 45 8e-05 6QDV-o nrPDB 45 8e-05 5OQL-L nrPDB 45 9e-05 6ELZ-p nrPDB 44 1e-04 5MWJ-A nrPDB 44 2e-04 5A9Q-7 nrPDB 44 2e-04 3BG0-A nrPDB 44 2e-04 2AQ5-A nrPDB 44 2e-04 1NR0-A nrPDB 43 3e-04 6CHG-A nrPDB 43 3e-04 4PSX-B nrPDB 42 5e-04 6E29-D nrPDB 42 5e-04 5TF2-A nrPDB 42 6e-04 4A11-B nrPDB 42 6e-04 5Y1U-A nrPDB 41 0.001 1PI6-A nrPDB 41 0.001 5K19-A nrPDB 41 0.001 3C9C-A nrPDB 40 0.002 5BJS-A nrPDB 39 0.003 4XFV-A nrPDB 39 0.005 6BX3-B nrPDB 39 0.005 4XYI-A nrPDB 39 0.005 3JZG-A nrPDB 39 0.005 3EI3-B nrPDB 39 0.006 3DWL-C nrPDB 38 0.008 4J0X-A nrPDB 38 0.009 5A31-R nrPDB 38 0.009 5WLC-SG nrPDB 38 0.010 5A9Q-2 nrPDB 38 0.012 3W15-A nrPDB 37 0.013 5WLC-LH nrPDB 36 0.030 5CXB-B nrPDB 35 0.056 4BH6-A nrPDB 35 0.060 5YZG-2 nrPDB 35 0.099 4E5Z-B nrPDB 34 0.14 5AJA-A nrPDB 33 0.25 5MC6-j nrPDB 33 0.31 5WLC-LV nrPDB 32 0.63 4NOX-A nrPDB 32 0.65 6CHG-D nrPDB 31 0.94 3JB9-S nrPDB 30 1.9 5WLC-LN nrPDB 30 2.0 1QGS-A nrPDB 30 2.1 2P9P-C nrPDB 30 2.9 5AMS-A nrPDB 30 3.0 1XDT-T nrPDB 30 3.2 6C0F-s nrPDB 29 3.3 6EM1-m nrPDB 29 3.4 6CB1-s nrPDB 29 3.9 6F1U-h nrPDB 29 5.5 1ZUA-X nrPDB 28 7.2 1DTP-A nrPDB 28 7.2 >6EOJ-D nrPDB Length = 470 Score = 976 bits (2523), Expect = 0.0, Method: Compositional matrix adjust. Identities = 465/465 (100%), Positives = 465/465 (100%) Query: 1 MDGHNQNQYQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETS 60 MDGHNQNQYQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETS Sbjct: 1 MDGHNQNQYQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETS 60 Query: 61 YTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLW 120 YTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLW Sbjct: 61 YTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLW 120 Query: 121 NASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESI 180 NASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESI Sbjct: 121 NASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESI 180 Query: 181 RDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKD 240 RDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKD Sbjct: 181 RDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKD 240 Query: 241 NLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMC 300 NLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMC Sbjct: 241 NLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMC 300 Query: 301 VRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNP 360 VRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNP Sbjct: 301 VRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNP 360 Query: 361 VGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFFGINNDINAVREKSEFGA 420 VGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFFGINNDINAVREKSEFGA Sbjct: 361 VGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFFGINNDINAVREKSEFGA 420 Query: 421 APPPPATLEPHALPNMNGFINKKPRQEIPGIDSNIKSSTLPGLSI 465 APPPPATLEPHALPNMNGFINKKPRQEIPGIDSNIKSSTLPGLSI Sbjct: 421 APPPPATLEPHALPNMNGFINKKPRQEIPGIDSNIKSSTLPGLSI 465 >5M25-A nrPDB Length = 434 Score = 108 bits (269), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 68/253 (26%), Positives = 119/253 (47%), Gaps = 1/253 (0%) Query: 125 FTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMA 184 + + + H AV+++K+S + +W+ S AD +IKIW ++ + H I D+A Sbjct: 135 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVA 194 Query: 185 FSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVK 244 +SS+ + V+ SDD LKIW+ S+GK + L GH V C+++P+ LI S S D V+ Sbjct: 195 WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 254 Query: 245 LWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDE 304 +WD ++G C+ ++ V F G+L+++ S D CR++D + D+ Sbjct: 255 IWDVKTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 313 Query: 305 TDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHI 364 ++ N A D +LK +D + T CI + G Sbjct: 314 NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW 373 Query: 365 FATAAKDRTIRFW 377 + ++D + W Sbjct: 374 IVSGSEDNLVYIW 386 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 53/218 (24%), Positives = 97/218 (44%), Gaps = 48/218 (22%) Query: 163 QPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDV 222 +PN+++ K A HT+++ + FS N + S D ++KIW +GK E+ +SGH + Sbjct: 132 KPNYAL-KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGI 190 Query: 223 KSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISK 282 W + L+ SAS D +K+WD SG C+ ++ + V F P + NL+++ S Sbjct: 191 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QSNLIVSGSF 249 Query: 283 DKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPI 342 D+S R++D++ C++ Sbjct: 250 DESVRIWDVKTGK----CLK---------------------------------------- 265 Query: 343 LTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRA 380 T+P AH ++++ +N G + +++ D R W A Sbjct: 266 -TLP-AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 301 >2H9P-A nrPDB Length = 329 Score = 107 bits (267), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 68/253 (26%), Positives = 119/253 (47%), Gaps = 1/253 (0%) Query: 125 FTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMA 184 + + + H AV+++K+S + +W+ S AD +IKIW ++ + H I D+A Sbjct: 30 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVA 89 Query: 185 FSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVK 244 +SS+ + V+ SDD LKIW+ S+GK + L GH V C+++P+ LI S S D V+ Sbjct: 90 WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 149 Query: 245 LWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDE 304 +WD ++G C+ ++ V F G+L+++ S D CR++D + D+ Sbjct: 150 IWDVKTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 208 Query: 305 TDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHI 364 ++ N A D +LK +D + T CI + G Sbjct: 209 NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW 268 Query: 365 FATAAKDRTIRFW 377 + ++D + W Sbjct: 269 IVSGSEDNLVYIW 281 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 53/218 (24%), Positives = 97/218 (44%), Gaps = 48/218 (22%) Query: 163 QPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDV 222 +PN+++ K A HT+++ + FS N + S D ++KIW +GK E+ +SGH + Sbjct: 27 KPNYAL-KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGI 85 Query: 223 KSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISK 282 W + L+ SAS D +K+WD SG C+ ++ + V F P + NL+++ S Sbjct: 86 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QSNLIVSGSF 144 Query: 283 DKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPI 342 D+S R++D++ C++ Sbjct: 145 DESVRIWDVKTGK----CLK---------------------------------------- 160 Query: 343 LTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRA 380 T+P AH ++++ +N G + +++ D R W A Sbjct: 161 -TLP-AHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 196 >5MZH-A nrPDB Length = 452 Score = 103 bits (256), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 75/288 (26%), Positives = 129/288 (44%), Gaps = 10/288 (3%) Query: 93 KHVIPAIQWT-PEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMI 151 K+V+ AI + P G ++V ++ LW+A + ++ H + + + ++ S + Sbjct: 136 KNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQSTIIA 195 Query: 152 SGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQ 211 +G D K+W + A H I + F++ VT S D+ ++W+ G+ Sbjct: 196 TGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQC 255 Query: 212 ERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHT--VLKTRF 269 VLSGH +V S ++ L+ S S D +LWD RSG C+S +K HT VL F Sbjct: 256 VHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLS--VKQGHTDEVLDVAF 313 Query: 270 QPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSL 329 G +++ S D S R++ + + V E + + ++P + T A D + Sbjct: 314 DAA-GTKMVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTRLIT-ASSDKTC 371 Query: 330 KHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 + +D L + H I S ++N G T +KD T R W Sbjct: 372 RLWDCDTG---ECLQVLEGHTDEIFSCAFNYEGDFIITGSKDNTCRIW 416 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 72/298 (24%), Positives = 128/298 (42%), Gaps = 50/298 (16%) Query: 124 SFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIW-----QPNFSM---------- 168 SFT +++AH +T ++ D I+G D K+W + F++ Sbjct: 83 SFTLFKVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAI 142 Query: 169 ------------------VKEIDA----------AHTESIRDMAFSSNDSKFVTCSDDNI 200 K DA H I ++F+ + T S DN Sbjct: 143 AFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQSTIIATGSMDNT 202 Query: 201 LKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKF 260 K+W+ G++ L+GH ++ S ++ LI + S D+ +LWD R+G C+ + Sbjct: 203 AKLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQCVHVLSGH 262 Query: 261 KHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETD-YMTLEWHPINESM 319 + V T+F G L+++ S D + R++D+R S + L + TD + + + M Sbjct: 263 RGEVSSTQFNYA-GTLVVSGSIDCTSRLWDVR-SGRCLSVKQGHTDEVLDVAFDAAGTKM 320 Query: 320 FTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 + A DGS + + L + + L H+ I+ +++NP G TA+ D+T R W Sbjct: 321 VS-ASADGSARLYHTLTGVCQHTLV---GHEGEISKVAFNPQGTRLITASSDKTCRLW 374 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 48/224 (21%), Positives = 99/224 (44%), Gaps = 9/224 (4%) Query: 156 DGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVL 215 D M++ +F++ K + AH + + AF+ + +F+T S D K+WN G++ L Sbjct: 74 DKMLEQQHHSFTLFKVL-RAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTL 132 Query: 216 SGHHWDVKSCDW-HPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKG 274 GH V + + +P I + S D KLWD +G ++ + ++ F P + Sbjct: 133 EGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNP-QS 191 Query: 275 NLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDL 334 ++ S D + +++D+ + + ++L ++ + + T GS H Sbjct: 192 TIIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVT-----GSFDHDSR 246 Query: 335 LQNLNE-PILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 L ++ + + H ++S +N G + + + D T R W Sbjct: 247 LWDVRTGQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLW 290 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 15/69 (21%), Positives = 36/69 (52%) Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDA 155 I + + P+G RL+ A+ LW+ + +++ H + + ++++ D++I+G Sbjct: 350 ISKVAFNPQGTRLITASSDKTCRLWDCDTGECLQVLEGHTDEIFSCAFNYEGDFIITGSK 409 Query: 156 DGMIKIWQP 164 D +IW+ Sbjct: 410 DNTCRIWKA 418 >5NNZ-B nrPDB Length = 415 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 64/290 (22%), Positives = 128/290 (44%), Gaps = 14/290 (4%) Query: 93 KHVIPAIQWT-PEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMI 151 ++V+ AI + P G ++ ++ LW+ + + H + + + ++ S + Sbjct: 134 RNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVA 193 Query: 152 SGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQ 211 +G D K+W H+ I ++F+++ + +T S D+ + +W+ G++ Sbjct: 194 TGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRK 253 Query: 212 ERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQP 271 +L GH ++ S ++ + LI + S D KLWD +G C++++ +L + F Sbjct: 254 VNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDY 313 Query: 272 TKGNLLMAISKDKSCRVFDIRYSMKELMCVRD----ETDYMTLEWHPINESMFTLACYDG 327 T G L+ S D + R+F S C+ E + + ++P + T D Sbjct: 314 T-GKLIATASADGTARIF----SAATRKCIAKLEGHEGEISKISFNPQGNHLLT-GSSDK 367 Query: 328 SLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 + + +D L + H I S ++N G+I T +KD T R W Sbjct: 368 TARIWDAQTG---QCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 60/287 (20%), Positives = 120/287 (41%), Gaps = 8/287 (2%) Query: 94 HVIPA--IQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHD-SDWM 150 H++P + G + +Y LW+ +S ++ H + V + +++ D + Sbjct: 91 HILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKI 150 Query: 151 ISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGK 210 +G D K+W HT I ++F+ + T S D K+W+ NG+ Sbjct: 151 ATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGE 210 Query: 211 QERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQ 270 + L GH ++ S ++ I + S D+ V +WD +G ++ ++ + F Sbjct: 211 EVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFN 270 Query: 271 PTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLK 330 +L++ S DK+C+++D + K + + D + + A DG+ + Sbjct: 271 W-DCSLILTGSMDKTCKLWDAT-NGKCVATLTGHDDEILDSCFDYTGKLIATASADGTAR 328 Query: 331 HFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 F + H+ I+ +S+NP G+ T + D+T R W Sbjct: 329 IF---SAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW 372 Score = 65.1 bits (157), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 60/260 (23%), Positives = 106/260 (40%), Gaps = 10/260 (3%) Query: 124 SFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDM 183 +F +++AH +T + + I+G D K+W H + + Sbjct: 81 TFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAI 140 Query: 184 AFSS-NDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNL 242 AF++ K T S D K+W+ GK GH ++ ++P+ L+A+ S D Sbjct: 141 AFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTT 200 Query: 243 VKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKE--LMC 300 KLWD ++G + ++ ++ F T G+ ++ S D + V+D K L+ Sbjct: 201 AKLWDIQNGEEVYTLRGHSAEIISLSFN-TSGDRIITGSFDHTVVVWDADTGRKVNILIG 259 Query: 301 VRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNP 360 E + W + S+ D + K +D LT HD I ++ Sbjct: 260 HCAEISSASFNW---DCSLILTGSMDKTCKLWDATNGKCVATLT---GHDDEILDSCFDY 313 Query: 361 VGHIFATAAKDRTIRFWTRA 380 G + ATA+ D T R ++ A Sbjct: 314 TGKLIATASADGTARIFSAA 333 Score = 35.8 bits (81), Expect = 0.044, Method: Compositional matrix adjust. Identities = 17/103 (16%), Positives = 45/103 (43%) Query: 61 YTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLW 120 YT ++ + G R+ + ++ + I I + P+G L+ + +W Sbjct: 313 YTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW 372 Query: 121 NASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ 163 +A + +++ H + + +++ + +I+G D +IW+ Sbjct: 373 DAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415 >6Q8F-A nrPDB Length = 514 Score = 87.8 bits (216), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 74/340 (21%), Positives = 157/340 (46%), Gaps = 32/340 (9%) Query: 65 IMPP----NAYRGRDRVINL-----PSKFT-HLSSNKVKHVIPAIQWTPEGRRLVVATYS 114 ++PP + +RG+ V ++ P++ + H+ + HV A +++P+G+ LV + Sbjct: 178 LLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECA-RFSPDGQYLVTGSVD 236 Query: 115 GEFSLWNASSFTFETLM--QAHDS------AVTTMKYSHDSDWMISGDADGMIKIWQ-PN 165 G +WN ++ + QA D+ AV M +S D++ + +G DG IK+W+ + Sbjct: 237 GFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQS 296 Query: 166 FSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSC 225 ++ + AH++ + ++FS + S+ ++ S D ++I +GK + GH V Sbjct: 297 GQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEA 356 Query: 226 DWHPEMGLIASASKDNLVKLWDPRSGNC------ISSILKFKHTVLKTRFQPTKGNLLMA 279 + + I SAS D VK+W+ ++ C + S TV P + Sbjct: 357 TFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVV 416 Query: 280 ISKDKSCRVFDIRYSMKELMCV--RDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQN 337 ++ + + +++ + R+ D++ P E ++ + D L F + Sbjct: 417 CNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVG-EDFVLYCFSTVTG 475 Query: 338 LNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 E LT+ H+K + ++++P ++ AT ++D ++ W Sbjct: 476 KLERTLTV---HEKDVIGIAHHPHQNLIATYSEDGLLKLW 512 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 46/206 (22%), Positives = 80/206 (38%), Gaps = 55/206 (26%) Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDA 155 + + ++ + +++ A++ + S + H S V ++ D ++IS + Sbjct: 311 VTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASS 370 Query: 156 DGMIKIWQ--------------------------------PNFSMVKEIDAAHTESIRDM 183 DG +KIW P +V + ++T I +M Sbjct: 371 DGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVV--CNRSNTVVIMNM 428 Query: 184 ------AFSSNDSK---FVTCS------------DDNILKIWNFSNGKQERVLSGHHWDV 222 +FSS + FV C+ +D +L ++ GK ER L+ H DV Sbjct: 429 QGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDV 488 Query: 223 KSCDWHPEMGLIASASKDNLVKLWDP 248 HP LIA+ S+D L+KLW P Sbjct: 489 IGIAHHPHQNLIATYSEDGLLKLWKP 514 >6N9G-C nrPDB Length = 353 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 66/297 (22%), Positives = 130/297 (43%), Gaps = 25/297 (8%) Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDA 155 + + W + RR+V ++ G+ +W++ + E + + V Y+ + G Sbjct: 66 VLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGL 125 Query: 156 DGMIKIW------QPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNG 209 D ++ N + K+ A HT + +F+++D + +T S D +W+ +G Sbjct: 126 DNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESG 185 Query: 210 KQERVLSGHHWDVKSCDWHP-EMG-LIASASKDNLVKLWDPRSGNCISSILKFKHTVLKT 267 + + GH DV D P E G S D +WD RSG C+ + + V Sbjct: 186 QLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDVNSV 245 Query: 268 RFQPTKGNLLMAISKDKSCRVFDIR-------YSMKELMCVRDETDYMTLEWHPINESMF 320 R+ P+ G+ + S D +CR++D+R YS + ++ D+ ++ + Sbjct: 246 RYYPS-GDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDF------SLSGRLL 298 Query: 321 TLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 D ++ +D+L+ IL + H+ +++L +P G F + + D T+R W Sbjct: 299 FAGYNDYTINVWDVLKGSRVSIL---FGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 38/175 (21%), Positives = 68/175 (38%), Gaps = 11/175 (6%) Query: 210 KQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRF 269 K R L GH V DW + I S+S+D V +WD + N ++ V+ + Sbjct: 54 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAY 113 Query: 270 QPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDE-----TDYMTLEWHPINESMFTLAC 324 P+ G + D C V+ + + E M + + T+Y++ ++ A Sbjct: 114 APS-GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTAS 172 Query: 325 YDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNP--VGHIFATAAKDRTIRFW 377 DG+ +D+ +L + H + L P G+ F + D+ W Sbjct: 173 GDGTCALWDVESG---QLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVW 224 >1VYH-C nrPDB Length = 410 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 64/267 (23%), Positives = 120/267 (44%), Gaps = 25/267 (9%) Query: 131 MQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDS 190 + H S VT + + M+S D IK+W + HT+S++D++F + Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163 Query: 191 KFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRS 250 +CS D +K+W+F + R + GH +V S P I SAS+D +K+W+ ++ Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWEVQT 223 Query: 251 GNCISSILKFKHTVLKTRFQPTK-GNLLMAISKDKSCRVF---------DIRYSMKELMC 300 G C+ + + V R P + G L+ + S D++ RV+ ++R + C Sbjct: 224 GYCVKTFTGHREWVRMVR--PNQDGTLIASCSNDQTVRVWVVATKECKAELREHRHVVEC 281 Query: 301 VR--DETDYMTLEWHPINESM-------FTLA-CYDGSLKHFDLLQNLNEPILTIPYAHD 350 + E+ Y ++ +E+ F L+ D ++K +D+ + L HD Sbjct: 282 ISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGM---CLMTLVGHD 338 Query: 351 KCITSLSYNPVGHIFATAAKDRTIRFW 377 + + ++ G + A D+T+R W Sbjct: 339 NWVRGVLFHSGGKFILSCADDKTLRVW 365 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 62/290 (21%), Positives = 122/290 (42%), Gaps = 25/290 (8%) Query: 108 LVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ-PNF 166 +V A+ +W+ + FE ++ H +V + + H + S AD IK+W F Sbjct: 123 MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGF 182 Query: 167 SMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCD 226 ++ + H ++ ++ N V+ S D +K+W G + +GH V+ Sbjct: 183 ECIRTMH-GHDHNVSSVSIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVR 241 Query: 227 WHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTK------------- 273 + + LIAS S D V++W + C + + + +H V + P Sbjct: 242 PNQDGTLIASCSNDQTVRVWVVATKECKAELREHRHVVECISWAPESSYSSISEATGSET 301 Query: 274 ------GNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDG 327 G L++ S+DK+ +++D+ M + V + + +H + F L+C D Sbjct: 302 KKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGK--FILSCADD 359 Query: 328 SLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 K + N+ + AH+ +TSL ++ T + D+T++ W Sbjct: 360 --KTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407 Score = 71.2 bits (173), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 45/217 (20%), Positives = 91/217 (41%), Gaps = 21/217 (9%) Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDA 155 + I + G+ L + LW+ F M HD V+++ + D ++S Sbjct: 153 VQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIVSASR 212 Query: 156 DGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVL 215 D IK+W+ + H E +R + + + + +CS+D +++W + + + L Sbjct: 213 DKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAEL 272 Query: 216 SGHHWDVKSCDWHPEMG--------------------LIASASKDNLVKLWDPRSGNCIS 255 H V+ W PE + S S+D +K+WD +G C+ Sbjct: 273 REHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLM 332 Query: 256 SILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIR 292 +++ + V F + G +++ + DK+ RV+D + Sbjct: 333 TLVGHDNWVRGVLFH-SGGKFILSCADDKTLRVWDYK 368 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 42/174 (24%), Positives = 74/174 (42%), Gaps = 22/174 (12%) Query: 76 RVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHD 135 RV + +K + +HV+ I W PE ++ ++ +A Sbjct: 259 RVWVVATKECKAELREHRHVVECISWAPES--------------------SYSSISEATG 298 Query: 136 SAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTC 195 S T K +++SG D IK+W + M H +R + F S ++C Sbjct: 299 SE--TKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSC 356 Query: 196 SDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPR 249 +DD L++W++ N + + L+ H V S D+H + + S D VK+W+ R Sbjct: 357 ADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410 Score = 48.1 bits (113), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 42/179 (23%), Positives = 79/179 (44%), Gaps = 23/179 (12%) Query: 211 QERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQ 270 ++ LSGH V +HP ++ SAS+D +K+WD +G+ ++ +V F Sbjct: 100 EKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFD 159 Query: 271 PTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTL-------- 322 + G LL + S D + +++D + C+R T+ H N S ++ Sbjct: 160 HS-GKLLASCSADMTIKLWDF----QGFECIR------TMHGHDHNVSSVSIMPNGDHIV 208 Query: 323 -ACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRA 380 A D ++K +++ T H + + + N G + A+ + D+T+R W A Sbjct: 209 SASRDKTIKMWEVQTGYCVKTFT---GHREWVRMVRPNQDGTLIASCSNDQTVRVWVVA 264 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 40/219 (18%), Positives = 83/219 (37%), Gaps = 21/219 (9%) Query: 94 HVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISG 153 H + ++ P G +V A+ +W + H V ++ + D + S Sbjct: 193 HNVSSVSIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASC 252 Query: 154 DADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSK--------------------FV 193 D +++W K H + ++++ S + Sbjct: 253 SNDQTVRVWVVATKECKAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLL 312 Query: 194 TCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNC 253 + S D +K+W+ S G L GH V+ +H I S + D +++WD ++ C Sbjct: 313 SGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRC 372 Query: 254 ISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIR 292 + ++ +H V F T ++ S D++ +V++ R Sbjct: 373 MKTLNAHEHFVTSLDFHKTAPYVVTG-SVDQTVKVWECR 410 >6MZM-G nrPDB Length = 800 Score = 82.0 bits (201), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 61/270 (22%), Positives = 99/270 (36%), Gaps = 47/270 (17%) Query: 130 LMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSND 189 ++ H V +S D ++++S DG +++W H + D FS Sbjct: 538 ILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYG 597 Query: 190 SKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPR 249 FV+ D + ++W + + R+ +GH DV +HP +A+ S D V+LWD Sbjct: 598 YYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVL 657 Query: 250 SGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMT 309 +GNC+ K + F P G L + D ++DI + LM Sbjct: 658 NGNCVRIFTGHKGPIHSLTFSP-NGRFLATGATDGRVLLWDIGHG---LMV--------- 704 Query: 310 LEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAA 369 G LK H + SL ++ G I A+ + Sbjct: 705 -----------------GELK-----------------GHTDTVCSLRFSRDGEILASGS 730 Query: 370 KDRTIRFWTRARPIDPNAYDDPTYNNKKIN 399 D T+R W + + DD T IN Sbjct: 731 MDNTVRLWDAIKAFEDLETDDFTTATGHIN 760 Score = 81.6 bits (200), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 55/228 (24%), Positives = 98/228 (42%), Gaps = 8/228 (3%) Query: 101 WTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIK 160 ++P+ L+ ++ G LW+ +FT + H+ V ++S + +SG D + + Sbjct: 551 FSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVAR 610 Query: 161 IWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHW 220 +W + I A H + F N + T S D +++W+ NG R+ +GH Sbjct: 611 LWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKG 670 Query: 221 DVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAI 280 + S + P +A+ + D V LWD G + + TV RF G +L + Sbjct: 671 PIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS-RDGEILASG 729 Query: 281 SKDKSCRVFDIRYSMKELMCVRDETDYMTLEWH---PINESMFTLACY 325 S D + R++D + ++L + D+ T H P N L Y Sbjct: 730 SMDNTVRLWDAIKAFEDL----ETDDFTTATGHINLPENSQELLLGTY 773 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 37/148 (25%), Positives = 64/148 (43%) Query: 100 QWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMI 159 Q++P G V + LW + + H + V ++ +S+++ +G AD + Sbjct: 592 QFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTV 651 Query: 160 KIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHH 219 ++W I H I + FS N T + D + +W+ +G L GH Sbjct: 652 RLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHT 711 Query: 220 WDVKSCDWHPEMGLIASASKDNLVKLWD 247 V S + + ++AS S DN V+LWD Sbjct: 712 DTVCSLRFSRDGEILASGSMDNTVRLWD 739 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 39/165 (23%), Positives = 71/165 (43%), Gaps = 5/165 (3%) Query: 213 RVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPT 272 ++L GH V + P+ + S+S+D V+LW ++ C+ + V T+F P Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSP- 595 Query: 273 KGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHF 332 G ++ D+ R++ + + D +HP N + D +++ + Sbjct: 596 YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHP-NSNYVATGSADRTVRLW 654 Query: 333 DLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 D+ LN + I H I SL+++P G AT A D + W Sbjct: 655 DV---LNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLW 696 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 17/70 (24%), Positives = 33/70 (47%) Query: 93 KHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMIS 152 K I ++ ++P GR L G LW+ ++ H V ++++S D + + S Sbjct: 669 KGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILAS 728 Query: 153 GDADGMIKIW 162 G D +++W Sbjct: 729 GSMDNTVRLW 738 >6HQA-B nrPDB Length = 722 Score = 81.3 bits (199), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 45/198 (22%), Positives = 91/198 (45%) Query: 95 VIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGD 154 + + ++P+ R L+ + LW+ ++T + H S+V +K+S + + Sbjct: 455 AVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKFSPMGHYFATAS 514 Query: 155 ADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERV 214 D ++W + I A H + + F N + T S D ++W+ + G+ RV Sbjct: 515 HDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTARMWDIARGECVRV 574 Query: 215 LSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKG 274 GH + P+ +ASA +D++V LWD +G I ++ + + + +G Sbjct: 575 FMGHSGAINCLAVSPDGRWLASAGEDSVVCLWDISTGRRIKAMRGHGRSSIYSLAFSREG 634 Query: 275 NLLMAISKDKSCRVFDIR 292 +L++ D S RV+D++ Sbjct: 635 TVLVSTGADNSVRVWDVK 652 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 57/271 (21%), Positives = 113/271 (41%), Gaps = 30/271 (11%) Query: 107 RLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNF 166 R + + + SL + +TF ++ +T +K++ DS + SG D IK+W + Sbjct: 366 RAKIKLSAAQASLPSVCMYTFHNT----NNDLTCLKFNDDSTMVASGFQDSFIKLWSIDG 421 Query: 167 SMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCD 226 S ++ + +++ ++ ++ V K R L GH V D Sbjct: 422 SPLRSL-------LKNDPYNQQNNDGVAV--------------KGSRRLVGHSGAVYGVD 460 Query: 227 WHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSC 286 + P+ + S S+D V+LW + C+ S +V +F P G+ S D++ Sbjct: 461 FSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKFSPM-GHYFATASHDQTA 519 Query: 287 RVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIP 346 R++ + + D +E+HP + +FT D + + +D+ + + + Sbjct: 520 RLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLFT-GSSDKTARMWDIARG---ECVRVF 575 Query: 347 YAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 H I L+ +P G A+A +D + W Sbjct: 576 MGHSGAINCLAVSPDGRWLASAGEDSVVCLW 606 Score = 35.0 bits (79), Expect = 0.064, Method: Compositional matrix adjust. Identities = 12/31 (38%), Positives = 20/31 (64%) Query: 348 AHDKCITSLSYNPVGHIFATAAKDRTIRFWT 378 H + + ++P+GH FATA+ D+T R W+ Sbjct: 493 GHSSSVWDVKFSPMGHYFATASHDQTARLWS 523 >6F3T-A nrPDB Length = 608 Score = 81.3 bits (199), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 61/270 (22%), Positives = 99/270 (36%), Gaps = 47/270 (17%) Query: 130 LMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSND 189 ++ H V +S D ++++S DG +++W H + D FS Sbjct: 346 ILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYG 405 Query: 190 SKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPR 249 FV+ D + ++W + + R+ +GH DV +HP +A+ S D V+LWD Sbjct: 406 YYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVL 465 Query: 250 SGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMT 309 +GNC+ K + F P G L + D ++DI + LM Sbjct: 466 NGNCVRIFTGHKGPIHSLTFSPN-GRFLATGATDGRVLLWDIGHG---LMV--------- 512 Query: 310 LEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAA 369 G LK H + SL ++ G I A+ + Sbjct: 513 -----------------GELK-----------------GHTDTVCSLRFSRDGEILASGS 538 Query: 370 KDRTIRFWTRARPIDPNAYDDPTYNNKKIN 399 D T+R W + + DD T IN Sbjct: 539 MDNTVRLWDAIKAFEDLETDDFTTATGHIN 568 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 55/233 (23%), Positives = 99/233 (42%), Gaps = 8/233 (3%) Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDA 155 + ++P+ L+ ++ G LW+ +FT + H+ V ++S + +SG Sbjct: 354 VYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGH 413 Query: 156 DGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVL 215 D + ++W + I A H + F N + T S D +++W+ NG R+ Sbjct: 414 DRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIF 473 Query: 216 SGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGN 275 +GH + S + P +A+ + D V LWD G + + TV RF G Sbjct: 474 TGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS-RDGE 532 Query: 276 LLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWH---PINESMFTLACY 325 +L + S D + R++D + ++L + D+ T H P N L Y Sbjct: 533 ILASGSMDNTVRLWDAIKAFEDL----ETDDFTTATGHINLPENSQELLLGTY 581 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 57/254 (22%), Positives = 106/254 (41%), Gaps = 17/254 (6%) Query: 124 SFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDM 183 S F T + A+ +T + + DS + G AD +++W ++ + A S+ D Sbjct: 268 SICFYTFLNAY-QGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDK 326 Query: 184 AFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLV 243 SDD + +I + + ++L GH V + P+ + S+S+D V Sbjct: 327 E-----------SDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTV 375 Query: 244 KLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRD 303 +LW ++ C+ + V T+F P G ++ D+ R++ + + Sbjct: 376 RLWSLQTFTCLVGYKGHNYPVWDTQFSPY-GYYFVSGGHDRVARLWATDHYQPLRIFAGH 434 Query: 304 ETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGH 363 D +HP N + D +++ +D+ LN + I H I SL+++P G Sbjct: 435 LADVNCTRFHP-NSNYVATGSADRTVRLWDV---LNGNCVRIFTGHKGPIHSLTFSPNGR 490 Query: 364 IFATAAKDRTIRFW 377 AT A D + W Sbjct: 491 FLATGATDGRVLLW 504 >5UZ7-B nrPDB Length = 351 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 76/289 (26%), Positives = 125/289 (43%), Gaps = 14/289 (4%) Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDA 155 I A+ W + R LV A+ G+ +W++ + + S V T Y+ +++ G Sbjct: 69 IYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGL 128 Query: 156 DGMIKIW-----QPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGK 210 D + I+ + N + +E+ A HT + F +D++ VT S D +W+ G+ Sbjct: 129 DNICSIYNLKTREGNVRVSREL-AGHTGYLSCCRFL-DDNQIVTSSGDTTCALWDIETGQ 186 Query: 211 QERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQ 270 Q +GH DV S P+ L S + D KLWD R G C + + + F Sbjct: 187 QTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFF 246 Query: 271 PTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINES-MFTLACYDG-S 328 P GN S D +CR+FD+R +ELM + + ++S LA YD + Sbjct: 247 P-NGNAFATGSDDATCRLFDLRAD-QELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFN 304 Query: 329 LKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 +D L+ +L HD ++ L G AT + D ++ W Sbjct: 305 CNVWDALKADRAGVLA---GHDNRVSCLGVTDDGMAVATGSWDSFLKIW 350 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 44/212 (20%), Positives = 79/212 (37%), Gaps = 48/212 (22%) Query: 210 KQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRF 269 + R L GH + + W + L+ SAS+D + +WD + N + +I V+ + Sbjct: 57 RTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY 116 Query: 270 QPT---------------------KGNL-----------------------LMAISKDKS 285 P+ +GN+ ++ S D + Sbjct: 117 APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTT 176 Query: 286 CRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTI 345 C ++DI + D M+L P + AC D S K +D+ + + T Sbjct: 177 CALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGAC-DASAKLWDVREGMCRQTFT- 234 Query: 346 PYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 H+ I ++ + P G+ FAT + D T R + Sbjct: 235 --GHESDINAICFFPNGNAFATGSDDATCRLF 264 Score = 29.6 bits (65), Expect = 2.6, Method: Compositional matrix adjust. Identities = 24/113 (21%), Positives = 46/113 (40%), Gaps = 4/113 (3%) Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHD---SAVTTMKYSHDSDWMIS 152 I AI + P G + L++ + E + +HD +T++ +S +++ Sbjct: 240 INAICFFPNGNAFATGSDDATCRLFDLRADQ-ELMTYSHDNIICGITSVSFSKSGRLLLA 298 Query: 153 GDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWN 205 G D +W + + A H + + + + T S D+ LKIWN Sbjct: 299 GYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 351 >5Y88-O nrPDB Length = 451 Score = 77.8 bits (190), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 57/225 (25%), Positives = 100/225 (44%), Gaps = 13/225 (5%) Query: 146 DSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWN 205 D++W I+G D +K+W +K A H ++RD+A S + S+D +K W+ Sbjct: 151 DNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDVAVSDRHPYLFSVSEDKTVKCWD 210 Query: 206 FSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVL 265 + R GH V++ HP + LIA+A +D+++KLWD R+ + +++ K + Sbjct: 211 LEKNQIIRDYYGHLSGVRTVSIHPTLDLIATAGRDSVIKLWDMRTRIPVITLVGHKGPIN 270 Query: 266 KTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACY 325 + + P ++ + S D + R++D+ + + HP S+ + AC Sbjct: 271 QVQCTPVDPQVVSS-STDATVRLWDVVAGKTMKVLTHHKRSVRATALHPKEFSVAS-ACT 328 Query: 326 DG----SLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFA 366 D L LL N I I +LS N +FA Sbjct: 329 DDIRSWGLAEGSLLTNFESEKTGI-------INTLSINQDDVLFA 366 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 32/135 (23%), Positives = 61/135 (45%), Gaps = 1/135 (0%) Query: 133 AHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKF 192 H S V T+ D + + D +IK+W + H I + + D + Sbjct: 222 GHLSGVRTVSIHPTLDLIATAGRDSVIKLWDMRTRIPVITLVGHKGPINQVQCTPVDPQV 281 Query: 193 VTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGN 252 V+ S D +++W+ GK +VL+ H V++ HP+ +ASA D+ ++ W G+ Sbjct: 282 VSSSTDATVRLWDVVAGKTMKVLTHHKRSVRATALHPKEFSVASACTDD-IRSWGLAEGS 340 Query: 253 CISSILKFKHTVLKT 267 +++ K ++ T Sbjct: 341 LLTNFESEKTGIINT 355 Score = 32.3 bits (72), Expect = 0.41, Method: Compositional matrix adjust. Identities = 28/113 (24%), Positives = 51/113 (45%), Gaps = 16/113 (14%) Query: 271 PTKGNLLMAISKDKSCRVFDIRYS------MKELMCVRDETDYMTLEWHPINESMFTLAC 324 P + S D + +V+D+ +M VRD + HP +F+++ Sbjct: 149 PVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRD---VAVSDRHPY---LFSVS- 201 Query: 325 YDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 D ++K +DL +N I+ Y H + ++S +P + ATA +D I+ W Sbjct: 202 EDKTVKCWDLEKN---QIIRDYYGHLSGVRTVSIHPTLDLIATAGRDSVIKLW 251 >3FM0-A nrPDB Length = 345 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 71/318 (22%), Positives = 132/318 (41%), Gaps = 37/318 (11%) Query: 99 IQWTPEGRRLVVATYSGEFSLWNASSFTF---ETLMQAHDSAVTTMKYSHDSDWMISGDA 155 + W P G L +W ++ L + H V + +S +++ S Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81 Query: 156 DGMIKIWQPN---FSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQE 212 D IW+ N F V ++ H ++ +A++ + + TCS D + +W + Sbjct: 82 DATTCIWKKNQDDFECVTTLEG-HENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEY 140 Query: 213 R---VLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGN--CISSILKFKHTVLKT 267 VL+ H DVK WHP L+ASAS D+ VKL+ + C +++ + TV Sbjct: 141 ECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSL 200 Query: 268 RFQPTKGNLLMAISKDKSCRVFDIRYSMKE--LMCVRDETDYMT--------------LE 311 F P+ G L + S D++ R++ E + C + + + Sbjct: 201 AFDPS-GQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIA 259 Query: 312 WHPINESMFTLACYDGSLKHF--DLLQNLNEPILTIP----YAHDKCITSLSYNPVG-HI 364 W + ++ T AC D +++ F D + +P ++ AH + + +++NP + Sbjct: 260 WCQLTGALAT-ACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGL 318 Query: 365 FATAAKDRTIRFWTRARP 382 A+ + D + FW RP Sbjct: 319 LASCSDDGEVAFWKYQRP 336 >6ID0-T nrPDB Length = 514 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 56/259 (21%), Positives = 105/259 (40%), Gaps = 29/259 (11%) Query: 130 LMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSND 189 ++ H V + + W ++G AD IKIW +K H ++R + S+ Sbjct: 199 VISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRS 258 Query: 190 SKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPR 249 +C +D +K W+ K R GH V D HP + ++ + S+D+ ++WD R Sbjct: 259 PYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVR 318 Query: 250 SGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMT 309 + + ++ + V R Q + ++ S D + R++D+ + + Sbjct: 319 TKASVHTLSGHTNAVATVRCQAAEPQIITG-SHDTTIRLWDLVAGKTRVTLTNHKKSVRA 377 Query: 310 LEWHPINESMFTLACY-----------DGSLKHFDLLQNLNEPILTIPYAHDKCITSLSY 358 + HP + +T A DGS +QNL+ H+ I +L+ Sbjct: 378 VVLHPRH---YTFASGSPDNIKQWKFPDGS-----FIQNLS--------GHNAIINTLTV 421 Query: 359 NPVGHIFATAAKDRTIRFW 377 N G + + A + T+ W Sbjct: 422 NSDG-VLVSGADNGTMHLW 439 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 42/186 (22%), Positives = 69/186 (37%), Gaps = 6/186 (3%) Query: 86 HLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSH 145 HL + V P QW V + +W+ +S + + H S V + S Sbjct: 203 HLGWVRCIAVEPGNQW------FVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVST 256 Query: 146 DSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWN 205 S ++ S D +K W ++ V H ++ + VTCS D+ +IW+ Sbjct: 257 RSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWD 316 Query: 206 FSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVL 265 LSGH V + I + S D ++LWD +G ++ K +V Sbjct: 317 VRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVR 376 Query: 266 KTRFQP 271 P Sbjct: 377 AVVLHP 382 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 49/217 (22%), Positives = 89/217 (41%), Gaps = 24/217 (11%) Query: 108 LVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFS 167 LV + +W+ + + H +AV T++ +I+G D I++W Sbjct: 303 LVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAG 362 Query: 168 MVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDW 227 + H +S+R + F + S DNI K W F +G + LSGH+ + + Sbjct: 363 KTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNI-KQWKFPDGSFIQNLSGHNAIINTLTV 421 Query: 228 HPEMGLIASASKDNLVKLWDPRSGNCISSI--------LKFKHTVLKTRFQPTKGNLLMA 279 + + G++ S + + + LWD R+G + L + + F ++ LL A Sbjct: 422 NSD-GVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTA 480 Query: 280 ISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPIN 316 DK+ +V+ E D T E HP++ Sbjct: 481 -EADKTIKVY-------------REDDTATEETHPVS 503 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 39/172 (22%), Positives = 71/172 (41%), Gaps = 13/172 (7%) Query: 210 KQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRF 269 K RV+SGH V+ P + S D +K+WD SG S+ TV + Sbjct: 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTV-RGVI 253 Query: 270 QPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMT----LEWHPINESMFTLACY 325 T+ L + +DK + +D+ Y+ +R +++ L+ HP + + T + Sbjct: 254 VSTRSPYLFSCGEDKQVKCWDLEYN----KVIRHYHGHLSAVYGLDLHPTIDVLVTCS-R 308 Query: 326 DGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 D + + +D+ + L+ H + ++ T + D TIR W Sbjct: 309 DSTARIWDVRTKASVHTLS---GHTNAVATVRCQAAEPQIITGSHDTTIRLW 357 >5OPT-p nrPDB Length = 318 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 64/266 (24%), Positives = 117/266 (43%), Gaps = 27/266 (10%) Query: 128 ETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSS 187 E ++ H + V+ + S++ D+ +S D +++W + + HT+ + + FS Sbjct: 60 ERRLEGHSAFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSP 119 Query: 188 NDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSC-DWHP--EMGLIASASKDNLVK 244 ++ + V+ DN L++WN + G H D SC + P E LI S DNLVK Sbjct: 120 DNRQIVSGGRDNALRVWNVKGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVK 179 Query: 245 LWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDE 304 +WD SG ++ + + + P G+L + KD R++D+ + E Sbjct: 180 VWDIASGRLLTDLKGHTNYITSVTVSP-DGSLCASSDKDGVARLWDL---------TKGE 229 Query: 305 TDYMTLEWHPINESMFT------LACYDGSLKHFDLLQNLNEPILTIPYAHDK------C 352 PIN+ F+ A + ++ FD L+N + + P A K C Sbjct: 230 ALSEMAAGAPINQICFSPNRYWMCAATEKGIRIFD-LENKDVIVELAPEAQQKSKKTPEC 288 Query: 353 ITSLSYNPVGHIFATAAKDRTIRFWT 378 + S++++ G+ + D IR W+ Sbjct: 289 M-SIAWSADGNTLYSGYTDNVIRVWS 313 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 47/191 (24%), Positives = 88/191 (46%), Gaps = 6/191 (3%) Query: 105 GRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQP 164 G V A++ LWN + + H V ++ +S D+ ++SG D +++W Sbjct: 79 GDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQIVSGGRDNALRVWNV 138 Query: 165 NFSMVKEID-AAHTESIRDMAFSSNDSK--FVTCSDDNILKIWNFSNGKQERVLSGHHWD 221 + + AHT+ + + FS + V+ DN++K+W+ ++G+ L GH Sbjct: 139 KGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASGRLLTDLKGHTNY 198 Query: 222 VKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAIS 281 + S P+ L AS+ KD + +LWD G +S + + + F P + M + Sbjct: 199 ITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSE-MAAGAPINQICFSPNR--YWMCAA 255 Query: 282 KDKSCRVFDIR 292 +K R+FD+ Sbjct: 256 TEKGIRIFDLE 266 >5FA5-B nrPDB Length = 367 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 65/242 (26%), Positives = 105/242 (43%), Gaps = 12/242 (4%) Query: 99 IQWTPEGRRLVVATYSGEFSLW----NASSFTFETLMQAHDSAVTTMKYSHDSDWMISGD 154 + W E R ++VA+ SG LW N + + HD V+T+ +SG Sbjct: 111 LTWVGE-RGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGS 169 Query: 155 ADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSN-DSKFVTCSDDNILKIWNFSNGKQER 213 D IK+W +V AH + +A S + DS F++CS+DN + +W+ K Sbjct: 170 KDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPAS 229 Query: 214 VL--SGHHWDVKSCDWHPEMG-LIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQ 270 + S + S WHP+ + ++ V L D +S +C+ S V F Sbjct: 230 QIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFS 289 Query: 271 PTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMT-LEWHPINESMFTLACYDGSL 329 P L ++S+D S V D S+ EL + D++ W P+N S+ T +D + Sbjct: 290 PHSVPFLASLSEDCSLAVLD--SSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 347 Query: 330 KH 331 H Sbjct: 348 VH 349 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 29/127 (22%), Positives = 53/127 (41%), Gaps = 5/127 (3%) Query: 236 SASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRY-- 293 S SKD +K+WD +SS V P K ++ ++ S+D ++D R Sbjct: 167 SGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPK 226 Query: 294 SMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCI 353 ++ C +L WHP +F +G++ L+ + + H +C+ Sbjct: 227 PASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVS---LVDTKSTSCVLSSAVHSQCV 283 Query: 354 TSLSYNP 360 T L ++P Sbjct: 284 TGLVFSP 290 >6QX9-4B nrPDB Length = 522 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 66/293 (22%), Positives = 117/293 (39%), Gaps = 18/293 (6%) Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDW------ 149 I ++P + L A +SG LW+ ++ H++ V + + S Sbjct: 234 ISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKD 293 Query: 150 --MISGDADGMIKIWQPNFSM-VKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNF 206 + S ADG +K+W + V +I+ R M S TC D + ++W+ Sbjct: 294 VNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRS-WRLWDL 352 Query: 207 SNGKQERVL--SGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTV 264 QE +L GH V +H + L + D ++WD R+G CI + + Sbjct: 353 E--AQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEI 410 Query: 265 LKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLAC 324 F P G + S D +C+V+D+R + +++ PI+ + Sbjct: 411 YGINFSPN-GYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGA 469 Query: 325 YDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 YD + K + P+ T+ H+ + L + G + AT + DRT + W Sbjct: 470 YDNTAKIWT--HPGWSPLKTLA-GHEGKVMGLDISSDGQLIATCSYDRTFKLW 519 >5Z56-q nrPDB Length = 504 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 53/194 (27%), Positives = 96/194 (49%), Gaps = 9/194 (4%) Query: 187 SNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW 246 S+ +K +T D + +++ S+ + L GH V S +HP L+ SAS D +++W Sbjct: 232 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 291 Query: 247 DPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETD 306 + +C+ + + V T G+ L++ S D+ DI+ + + L V DET Sbjct: 292 SVPNASCVQVVRAHESAVTGLSLHAT-GDYLLSSSDDQYWAFSDIQ-TGRVLTKVTDETS 349 Query: 307 YMTL---EWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGH 363 +L ++HP + +F D +K +DL + N + P H ITS++++ G+ Sbjct: 350 GCSLTCAQFHP-DGLIFGTGTMDSQIKIWDLKERTN--VANFP-GHSGPITSIAFSENGY 405 Query: 364 IFATAAKDRTIRFW 377 ATAA D +++ W Sbjct: 406 YLATAADDSSVKLW 419 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 40/180 (22%), Positives = 82/180 (45%), Gaps = 11/180 (6%) Query: 119 LWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ-PNFSMVKEIDAAHT 177 +++ SS ++ H VT++ + D + S D I+IW PN S V+ + AH Sbjct: 248 VFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVR-AHE 306 Query: 178 ESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSC-----DWHPEMG 232 ++ ++ + ++ SDD + W FS+ + RVL+ + C +HP+ Sbjct: 307 SAVTGLSLHATGDYLLSSSDD---QYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGL 363 Query: 233 LIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIR 292 + + + D+ +K+WD + +++ + F G L + D S +++D+R Sbjct: 364 IFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSE-NGYYLATAADDSSVKLWDLR 422 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 36/159 (22%), Positives = 68/159 (42%), Gaps = 8/159 (5%) Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDA 155 + ++ + P + A+ +W+ + + +++AH+SAVT + D+++S Sbjct: 267 VTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSD 326 Query: 156 DGMIKIW-----QPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGK 210 D + W Q + K D S+ F + F T + D+ +KIW+ Sbjct: 327 D---QYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERT 383 Query: 211 QERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPR 249 GH + S + +A+A+ D+ VKLWD R Sbjct: 384 NVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLR 422 Score = 32.0 bits (71), Expect = 0.56, Method: Compositional matrix adjust. Identities = 16/52 (30%), Positives = 28/52 (53%) Query: 327 GSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWT 378 G+ K+ + +E IL H K +TS+ ++P + +A+ D TIR W+ Sbjct: 241 GADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 292 >5WLC-LO nrPDB Length = 923 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 65/301 (21%), Positives = 122/301 (40%), Gaps = 63/301 (20%) Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDA 155 + + + P R L V SGEF L++ FT + + V T+ + +W+ G + Sbjct: 263 VKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSS 322 Query: 156 D-GMIKI--WQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQE 212 G + + WQ ++K+ Sbjct: 323 KLGQLLVYEWQSESYILKQ----------------------------------------- 341 Query: 213 RVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPT 272 GH S + P+ + +AS+D +K+WD SG C+++ + +V +F Sbjct: 342 ---QGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQF-AK 397 Query: 273 KGNLLMAISKDKSCRVFD-IRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKH 331 +G ++ + S D + R +D IRY + + L P E + C GSL + Sbjct: 398 RGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGE----VVCA-GSLDN 452 Query: 332 FDL----LQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWT---RARPID 384 FD+ +Q +L H+ ++ LS++ + A+A+ D+TIR W+ R++ ++ Sbjct: 453 FDIHVWSVQT--GQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVE 510 Query: 385 P 385 P Sbjct: 511 P 511 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 39/197 (19%), Positives = 83/197 (42%), Gaps = 5/197 (2%) Query: 120 WNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTES 179 W + S+ + Q H + ++ YS D +++ DG IK+W HT S Sbjct: 332 WQSESYILK--QQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSS 389 Query: 180 IRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSC-DWHPEMGLIASAS 238 + + F+ + S D ++ W+ + R +G +C P ++ + S Sbjct: 390 VTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGS 449 Query: 239 KDNL-VKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKE 297 DN + +W ++G + ++ + V F + ++L + S DK+ R++ I ++ Sbjct: 450 LDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQ-ENSVLASASWDKTIRIWSIFGRSQQ 508 Query: 298 LMCVRDETDYMTLEWHP 314 + + +D + L P Sbjct: 509 VEPIEVYSDVLALSMRP 525 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 50/210 (23%), Positives = 81/210 (38%), Gaps = 26/210 (12%) Query: 99 IQWTPEGRRLV--VATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDAD 156 I ++ +G++L+ V F L N SFTFE H + + + +IS D D Sbjct: 20 ITFSDDGKQLLSPVGNRVSVFDLINNKSFTFE---YEHRKNIAAIDLNKQGTLLISIDED 76 Query: 157 GMIKIWQPNFSMVKEIDAAH----TESIRDMAFSSNDSKFVTCSDDNILKIW-------- 204 G + NF K + H E + FS D + + L+IW Sbjct: 77 GRAIL--VNF---KARNVLHHFNFKEKCSAVKFSP-DGRLFALASGRFLQIWKTPDVNKD 130 Query: 205 -NFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW--DPRSGNCISSILKFK 261 F+ + RV +GH D+ S W + I + SKD K+W D N ++ Sbjct: 131 RQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGH 190 Query: 262 HTVLKTRFQPTKGNLLMAISKDKSCRVFDI 291 + F + +SKD + V++ Sbjct: 191 RDYVMGAFFSHDQEKIYTVSKDGAVFVWEF 220 >5I2T-A nrPDB Length = 742 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 65/299 (21%), Positives = 123/299 (41%), Gaps = 59/299 (19%) Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDA 155 + + + P R L V SGEF L++ FT + + V T+ + +W+ G + Sbjct: 288 VKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSS 347 Query: 156 D-GMIKI--WQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQE 212 G + + WQ ++K+ H +S +A+S Sbjct: 348 KLGQLLVYEWQSESYILKQ--QGHFDSTNSLAYS-------------------------- 379 Query: 213 RVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPT 272 P+ + +AS+D +K+WD SG C+++ + +V +F Sbjct: 380 ----------------PDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQF-AK 422 Query: 273 KGNLLMAISKDKSCRVFD-IRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKH 331 +G ++ + S D + R +D IRY + + L P E + C GSL + Sbjct: 423 RGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGE----VVCA-GSLDN 477 Query: 332 FDL--LQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWT---RARPIDP 385 FD+ +L H+ ++ LS++ + A+A+ D+TIR W+ R++ ++P Sbjct: 478 FDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEP 536 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 39/197 (19%), Positives = 83/197 (42%), Gaps = 5/197 (2%) Query: 120 WNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTES 179 W + S+ + Q H + ++ YS D +++ DG IK+W HT S Sbjct: 357 WQSESYILK--QQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSS 414 Query: 180 IRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSC-DWHPEMGLIASAS 238 + + F+ + S D ++ W+ + R +G +C P ++ + S Sbjct: 415 VTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGS 474 Query: 239 KDNL-VKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKE 297 DN + +W ++G + ++ + V F + ++L + S DK+ R++ I ++ Sbjct: 475 LDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQ-ENSVLASASWDKTIRIWSIFGRSQQ 533 Query: 298 LMCVRDETDYMTLEWHP 314 + + +D + L P Sbjct: 534 VEPIEVYSDVLALSMRP 550 Score = 41.6 bits (96), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 50/210 (23%), Positives = 81/210 (38%), Gaps = 26/210 (12%) Query: 99 IQWTPEGRRLV--VATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDAD 156 I ++ +G++L+ V F L N SFTFE H + + + +IS D D Sbjct: 45 ITFSDDGKQLLSPVGNRVSVFDLINNKSFTFE---YEHRKNIAAIDLNKQGTLLISIDED 101 Query: 157 GMIKIWQPNFSMVKEIDAAH----TESIRDMAFSSNDSKFVTCSDDNILKIW-------- 204 G + NF K + H E + FS D + + L+IW Sbjct: 102 GRAIL--VNF---KARNVLHHFNFKEKCSAVKFSP-DGRLFALASGRFLQIWKTPDVNKD 155 Query: 205 -NFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW--DPRSGNCISSILKFK 261 F+ + RV +GH D+ S W + I + SKD K+W D N ++ Sbjct: 156 RQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGH 215 Query: 262 HTVLKTRFQPTKGNLLMAISKDKSCRVFDI 291 + F + +SKD + V++ Sbjct: 216 RDYVMGAFFSHDQEKIYTVSKDGAVFVWEF 245 >3DM0-A nrPDB Length = 694 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 45/169 (26%), Positives = 77/169 (45%), Gaps = 5/169 (2%) Query: 94 HVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISG 153 H + + + +G+ + ++ GE LW+ ++ H V ++ +S D+ ++S Sbjct: 431 HFVEDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSA 490 Query: 154 DADGMIKIWQPNFS---MVKEIDAAHTESIRDMAFSSNDSK--FVTCSDDNILKIWNFSN 208 D IK+W + E H + + + FS N + V+ S D +K+WN SN Sbjct: 491 SRDRTIKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSN 550 Query: 209 GKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSI 257 K L+GH V + P+ L AS KD +V LWD G + S+ Sbjct: 551 CKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSL 599 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 46/225 (20%), Positives = 93/225 (41%), Gaps = 30/225 (13%) Query: 175 AHTESIRDMAFS-SNDSKFVTCSDDNILKIWNFSN-----GKQERVLSGHHWDVKSCDWH 228 AHT+ + +A N V+ S D + +W + G +R L+GH V+ Sbjct: 380 AHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVLS 439 Query: 229 PEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRV 288 + S S D ++LWD +G + VL F ++ A S+D++ ++ Sbjct: 440 SDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSA-SRDRTIKL 498 Query: 289 F----DIRYSMKE--------LMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQ 336 + + +Y++ E + CVR + + + A +D ++K ++L Sbjct: 499 WNTLGECKYTISEGGEGHRDWVSCVRFSPNTL--------QPTIVSASWDKTVKVWNL-- 548 Query: 337 NLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRAR 381 N + + H +++++ +P G + A+ KD + W A Sbjct: 549 -SNCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAE 592 >4V8M-A7 nrPDB Length = 318 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 59/263 (22%), Positives = 113/263 (42%), Gaps = 29/263 (11%) Query: 131 MQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDS 190 ++ H + V+ + S++ ++ +S D +++W + HT+ + +AFS ++ Sbjct: 63 LEGHSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNR 122 Query: 191 KFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSC-DWHPEMG--LIASASKDNLVKLWD 247 + V+ DN L++WN + G H D SC + P + +I S DNLVK+WD Sbjct: 123 QIVSGGRDNALRVWNVKGECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWD 182 Query: 248 PRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDY 307 +G ++ + + V P G+L + KD R++D+ + E Sbjct: 183 LATGRLVTDLKGHTNYVTSVTVSP-DGSLCASSDKDGVARLWDL---------TKGEALS 232 Query: 308 MTLEWHPINESMFT------LACYDGSLKHFDLLQNLNEPILTIPYAHD-------KCIT 354 PIN+ F+ A + ++ FDL + I+ + H +C+ Sbjct: 233 EMAAGAPINQICFSPNRYWMCAATEKGIRIFDLEN--KDIIVELAPEHQGSKKIVPECV- 289 Query: 355 SLSYNPVGHIFATAAKDRTIRFW 377 S++++ G + D IR W Sbjct: 290 SIAWSADGSTLYSGYTDNVIRVW 312 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 49/191 (25%), Positives = 88/191 (46%), Gaps = 6/191 (3%) Query: 105 GRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQP 164 G V A++ LWN + + H V ++ +S D+ ++SG D +++W Sbjct: 79 GNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQIVSGGRDNALRVWNV 138 Query: 165 NFSMVKEID-AAHTESIRDMAFS-SNDSKFVTCSD-DNILKIWNFSNGKQERVLSGHHWD 221 + + AHT+ + + FS S D+ + DN++K+W+ + G+ L GH Sbjct: 139 KGECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGRLVTDLKGHTNY 198 Query: 222 VKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAIS 281 V S P+ L AS+ KD + +LWD G +S + + + F P + M + Sbjct: 199 VTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSE-MAAGAPINQICFSPNR--YWMCAA 255 Query: 282 KDKSCRVFDIR 292 +K R+FD+ Sbjct: 256 TEKGIRIFDLE 266 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 61/270 (22%), Positives = 124/270 (45%), Gaps = 26/270 (9%) Query: 124 SFTFETLMQAHDSAVTTM---KYSHDSDWMISGDADGMIKIWQPN---------FSMVKE 171 + +E + H VT++ + + ++S D + W PN + + Sbjct: 2 AVAYEGQLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDR 61 Query: 172 IDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEM 231 H+ + D+A S+N + V+ S D+ L++WN NG+ + GH DV S + P+ Sbjct: 62 RLEGHSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDN 121 Query: 232 GLIASASKDNLVKLWDPRSGNCISSILKFKHT--VLKTRFQPT-KGNLLMAISKDKSCRV 288 I S +DN +++W+ + G C+ ++ + HT V RF P+ ++++ D +V Sbjct: 122 RQIVSGGRDNALRVWNVK-GECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKV 180 Query: 289 FDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQN--LNEPILTIP 346 +D+ + + + ++ T+Y+T + S+ + DG + +DL + L+E P Sbjct: 181 WDLA-TGRLVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAP 239 Query: 347 YAHDKCITSLSYNPVGHIFATAAKDRTIRF 376 I + ++P + AA ++ IR Sbjct: 240 ------INQICFSP-NRYWMCAATEKGIRI 262 Score = 28.9 bits (63), Expect = 5.4, Method: Compositional matrix adjust. Identities = 36/188 (19%), Positives = 71/188 (37%), Gaps = 53/188 (28%) Query: 73 GRD---RVINLPSKFTH-LSSNKVKHVIPAIQWTP--EGRRLVVATYSGEFSLWNASSFT 126 GRD RV N+ + H LS + ++++P + +V + +W+ ++ Sbjct: 128 GRDNALRVWNVKGECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGR 187 Query: 127 FETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIW------------------QPNFS- 167 T ++ H + VT++ S D S D DG+ ++W Q FS Sbjct: 188 LVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPINQICFSP 247 Query: 168 ----------------------MVKEIDAAHTESIR------DMAFSSNDSKFVTCSDDN 199 ++ E+ H S + +A+S++ S + DN Sbjct: 248 NRYWMCAATEKGIRIFDLENKDIIVELAPEHQGSKKIVPECVSIAWSADGSTLYSGYTDN 307 Query: 200 ILKIWNFS 207 ++++W S Sbjct: 308 VIRVWGVS 315 >5WYK-BB nrPDB Length = 943 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 50/208 (24%), Positives = 94/208 (45%), Gaps = 18/208 (8%) Query: 100 QWTPEGRRLVVATYSGEFSLWN-ASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGM 158 ++ P G +++ T +GE L++ ASS +T+ AHD+A+ ++ + D +++G AD Sbjct: 437 KFLPGGLLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKT 496 Query: 159 IKIWQ----------------PNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILK 202 +K W P + + T+ I + S +D DN +K Sbjct: 497 VKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTVK 556 Query: 203 IWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKH 262 ++ + K L GH V S D + +I ++S D +K+W G+C S+ + Sbjct: 557 VFFLDSMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKSLFAHQD 616 Query: 263 TVLKTRFQPTKGNLLMAISKDKSCRVFD 290 +++ +F P N + SKD + +D Sbjct: 617 SIMNVKFLPQSHNFF-SCSKDAVVKYWD 643 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 40/165 (24%), Positives = 78/165 (47%) Query: 83 KFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMK 142 K H ++ ++ I ++ +P+ R L ++ ++ S F + H V ++ Sbjct: 521 KLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTVKVFFLDSMKFYLSLYGHKLPVLSID 580 Query: 143 YSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILK 202 S DS +I+ AD IKIW +F + AH +SI ++ F F +CS D ++K Sbjct: 581 ISFDSKMIITSSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQSHNFFSCSKDAVVK 640 Query: 203 IWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWD 247 W+ + + L H +V + + G + S+S D+ +++W+ Sbjct: 641 YWDGEKFECIQKLYAHQSEVWALAVATDGGFVVSSSHDHSIRIWE 685 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 38/143 (26%), Positives = 61/143 (42%), Gaps = 3/143 (2%) Query: 64 DIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNAS 123 D++ G +V +L SK L+ N K I +Q+ G RL+ + +W+ Sbjct: 92 DLLAVGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLV 151 Query: 124 SFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDM 183 +++H ++T + DW+IS DGMIK+W E AHT + Sbjct: 152 GEVGLYKLRSHKDSITGF-WCQGEDWLISTSKDGMIKLWDLKTHQCIETHIAHTGECWGL 210 Query: 184 AFSSNDSKFVTCSDDNILKIWNF 206 A D +T D+ +KIW Sbjct: 211 AV--KDDLLITTGTDSQVKIWKL 231 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 32/124 (25%), Positives = 56/124 (45%), Gaps = 1/124 (0%) Query: 133 AHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKF 192 A + T ++ D+D + G ADG+IK+W V H +I + F ++ Sbjct: 77 AKPAECTYLEAHKDTDLLAVGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRL 136 Query: 193 VTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGN 252 ++ S D+ + +W+ L H D + W + S SKD ++KLWD ++ Sbjct: 137 ISGSKDSNIIVWDLVGEVGLYKLRSHK-DSITGFWCQGEDWLISTSKDGMIKLWDLKTHQ 195 Query: 253 CISS 256 CI + Sbjct: 196 CIET 199 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 30/109 (27%), Positives = 48/109 (44%), Gaps = 3/109 (2%) Query: 182 DMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDN 241 D++F S +T S D +KIW G + L H + + + P+ S SKD Sbjct: 580 DISFDSK--MIITSSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQSHNFFSCSKDA 637 Query: 242 LVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFD 290 +VK WD CI + + V T G +++ S D S R+++ Sbjct: 638 VVKYWDGEKFECIQKLYAHQSEVWALAV-ATDGGFVVSSSHDHSIRIWE 685 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 40/163 (24%), Positives = 63/163 (38%), Gaps = 49/163 (30%) Query: 215 LSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKG 274 L G DV+S D + L+A+AS +L K+W+ ++ CI Sbjct: 387 LQGQRTDVRSIDISDDNKLLATASNGSL-KIWNIKTHKCI-------------------- 425 Query: 275 NLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDL 334 R F+ Y++ T ++ P + L +G L+ FDL Sbjct: 426 ------------RTFECGYAL-------------TCKFLP-GGLLVILGTRNGELQLFDL 459 Query: 335 LQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 + + TI AHD I SL G T + D+T++FW Sbjct: 460 ASS--SLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFW 500 Score = 35.4 bits (80), Expect = 0.047, Method: Compositional matrix adjust. Identities = 45/249 (18%), Positives = 90/249 (36%), Gaps = 64/249 (25%) Query: 187 SNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW 246 S+D+K + + + LKIWN K R + +C + P L+ +++ ++L+ Sbjct: 400 SDDNKLLATASNGSLKIWNIKTHKCIRTFECGY--ALTCKFLPGGLLVILGTRNGELQLF 457 Query: 247 DPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYS------------ 294 D S + + +I + + + G L+ S DK+ + +D + Sbjct: 458 DLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFL 517 Query: 295 -------------MKELMCVRDETD--YMTLEWHPINESMFTLACYDGSLKHFDLLQNLN 339 +++CVR D Y+ + +F L S+K + L Sbjct: 518 PVLKLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTVKVFFL----DSMKFYLSLYGHK 573 Query: 340 EPILTIP-------------------------------YAHDKCITSLSYNPVGHIFATA 368 P+L+I +AH I ++ + P H F + Sbjct: 574 LPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQSHNFFSC 633 Query: 369 AKDRTIRFW 377 +KD +++W Sbjct: 634 SKDAVVKYW 642 Score = 30.0 bits (66), Expect = 2.2, Method: Compositional matrix adjust. Identities = 25/130 (19%), Positives = 57/130 (43%), Gaps = 2/130 (1%) Query: 76 RVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHD 135 +V L S +LS K + +I + + + ++ ++ +W + AH Sbjct: 556 KVFFLDSMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKSLFAHQ 615 Query: 136 SAVTTMKYSHDSDWMISGDADGMIKIWQ-PNFSMVKEIDAAHTESIRDMAFSSNDSKFVT 194 ++ +K+ S S D ++K W F ++++ AH + +A +++ V+ Sbjct: 616 DSIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQKL-YAHQSEVWALAVATDGGFVVS 674 Query: 195 CSDDNILKIW 204 S D+ ++IW Sbjct: 675 SSHDHSIRIW 684 >4LG8-A nrPDB Length = 354 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 53/194 (27%), Positives = 96/194 (49%), Gaps = 9/194 (4%) Query: 187 SNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW 246 S+ +K +T D + +++ S+ + L GH V S +HP L+ SAS D +++W Sbjct: 82 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIW 141 Query: 247 DPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETD 306 + +C+ + + V T G+ L++ S D+ DI+ + + L V DET Sbjct: 142 SVPNASCVQVVRAHESAVTGLSLHAT-GDYLLSSSDDQYWAFSDIQ-TGRVLTKVTDETS 199 Query: 307 YMTL---EWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGH 363 +L ++HP + +F D +K +DL + N + P H ITS++++ G+ Sbjct: 200 GCSLTCAQFHP-DGLIFGTGTMDSQIKIWDLKERTN--VANFP-GHSGPITSIAFSENGY 255 Query: 364 IFATAAKDRTIRFW 377 ATAA D +++ W Sbjct: 256 YLATAADDSSVKLW 269 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 40/180 (22%), Positives = 82/180 (45%), Gaps = 11/180 (6%) Query: 119 LWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ-PNFSMVKEIDAAHT 177 +++ SS ++ H VT++ + D + S D I+IW PN S V+ + AH Sbjct: 98 VFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVV-RAHE 156 Query: 178 ESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSC-----DWHPEMG 232 ++ ++ + ++ SDD + W FS+ + RVL+ + C +HP+ Sbjct: 157 SAVTGLSLHATGDYLLSSSDD---QYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGL 213 Query: 233 LIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIR 292 + + + D+ +K+WD + +++ + F G L + D S +++D+R Sbjct: 214 IFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSE-NGYYLATAADDSSVKLWDLR 272 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 36/159 (22%), Positives = 68/159 (42%), Gaps = 8/159 (5%) Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDA 155 + ++ + P + A+ +W+ + + +++AH+SAVT + D+++S Sbjct: 117 VTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSD 176 Query: 156 DGMIKIW-----QPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGK 210 D + W Q + K D S+ F + F T + D+ +KIW+ Sbjct: 177 D---QYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERT 233 Query: 211 QERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPR 249 GH + S + +A+A+ D+ VKLWD R Sbjct: 234 NVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLR 272 Score = 32.0 bits (71), Expect = 0.65, Method: Compositional matrix adjust. Identities = 16/52 (30%), Positives = 28/52 (53%) Query: 327 GSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWT 378 G+ K+ + +E IL H K +TS+ ++P + +A+ D TIR W+ Sbjct: 91 GADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 142 >6G51-g nrPDB Length = 317 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 44/162 (27%), Positives = 76/162 (46%), Gaps = 5/162 (3%) Query: 94 HVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISG 153 H + + + +G+ + ++ G LW+ ++ T H V ++ +S D+ ++SG Sbjct: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123 Query: 154 DADGMIKIWQPNFSMVKEI--DAAHTESIRDMAFSSNDSK--FVTCSDDNILKIWNFSNG 209 D IK+W + K D +H+E + + FS N S V+C D ++K+WN +N Sbjct: 124 SRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182 Query: 210 KQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSG 251 K + GH + + P+ L AS KD LWD G Sbjct: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEG 224 Score = 58.9 bits (141), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 64/257 (24%), Positives = 103/257 (40%), Gaps = 15/257 (5%) Query: 131 MQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDS 190 ++ H V+ + S D + +SG DG +++W HT+ + +AFSS++ Sbjct: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 118 Query: 191 KFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSC-DWHPEMG--LIASASKDNLVKLWD 247 + V+ S D +K+WN + V H + SC + P +I S D LVK+W+ Sbjct: 119 QIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178 Query: 248 PRSGNCISSILKFKHT-VLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETD 306 NC HT L T G+L + KD ++D+ K L + Sbjct: 179 L--ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEG-KHLYTLDGGDI 235 Query: 307 YMTLEWHPINESMFTLACYDGSLKHFDLLQNL------NEPILTIPYAHDKCITSLSYNP 360 L + P + A S+K +DL + E I T A TSL+++ Sbjct: 236 INALCFSP--NRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSA 293 Query: 361 VGHIFATAAKDRTIRFW 377 G D +R W Sbjct: 294 DGQTLFAGYTDNLVRVW 310 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 59/262 (22%), Positives = 110/262 (41%), Gaps = 16/262 (6%) Query: 125 FTFETLMQAHDSAVTTMKYS-HDSDWMISGDADGMIKIW-----QPNFSMVKEIDAAHTE 178 T ++ H+ VT + + D ++S D I +W + N+ + + H+ Sbjct: 5 MTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSH 64 Query: 179 SIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASAS 238 + D+ SS+ ++ S D L++W+ + G R GH DV S + + I S S Sbjct: 65 FVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS 124 Query: 239 KDNLVKLWDPRSGNCISSILKFKHT--VLKTRFQPTKGN-LLMAISKDKSCRVFDIRYSM 295 +D +KLW+ G C ++ H+ V RF P N ++++ DK +V+++ Sbjct: 125 RDKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK 183 Query: 296 KELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITS 355 + + T Y+ + + S C G +L +LNE I + Sbjct: 184 LKTNHI-GHTGYL----NTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINA 238 Query: 356 LSYNPVGHIFATAAKDRTIRFW 377 L ++P + AA +I+ W Sbjct: 239 LCFSP-NRYWLCAATGPSIKIW 259 >5OQL-d nrPDB Length = 446 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 60/261 (22%), Positives = 119/261 (45%), Gaps = 20/261 (7%) Query: 130 LMQAHDSAVTTMKYSHDS-DWMISGDADGMIKIWQPNFSMVKEID---AAHTESIRDMAF 185 L H V +M +S + + SG DG++K+W + + E AAH ++ + F Sbjct: 61 LGNGHVQGVYSMCKDKNSLNCIASGSGDGVVKVW--DLTTRDEETWRVAAHNNIVKGLTF 118 Query: 186 SSNDSKFVTCSDDNILKIWN-FSNGKQERVLSGHHWD----VKSCDWHPEMGLIASASKD 240 + ND K ++C+ D I K+W+ +++ ++ W S +H A++S Sbjct: 119 T-NDKKLLSCATDGI-KLWDPYASPSNTTPIAT--WQEGGPYTSLSFHRSANTFAASSGQ 174 Query: 241 NLVKLWDPRSGNCISSIL--KFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKEL 298 +++WD +I F T+ F + +++ +++ D+S +FD+R +M + Sbjct: 175 GCIRIWDLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVI 234 Query: 299 MCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSY 358 V + ++P+ +A D ++ FD +N ++ L I H + + + Sbjct: 235 KTVL-HFACNRIVFNPMEAMNLAVASEDHNIYIFDA-RNFDKA-LNIQKGHVAAVMDVEF 291 Query: 359 NPVGHIFATAAKDRTIRFWTR 379 +P G + + DRTIR W R Sbjct: 292 SPTGEELVSGSYDRTIRLWRR 312 Score = 34.3 bits (77), Expect = 0.12, Method: Compositional matrix adjust. Identities = 16/70 (22%), Positives = 34/70 (48%), Gaps = 1/70 (1%) Query: 99 IQWTPEGRRLVVATYSGEFSLWNA-SSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADG 157 ++++P G LV +Y LW + + + V ++ DS ++++G DG Sbjct: 289 VEFSPTGEELVSGSYDRTIRLWRRDAGHSRDVYHTKRMQRVFRTMWTMDSKYILTGSDDG 348 Query: 158 MIKIWQPNFS 167 +++W+ N S Sbjct: 349 NVRLWRANAS 358 Score = 33.1 bits (74), Expect = 0.25, Method: Compositional matrix adjust. Identities = 21/83 (25%), Positives = 33/83 (39%), Gaps = 1/83 (1%) Query: 165 NFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVL-SGHHWDVK 223 NF I H ++ D+ FS + V+ S D +++W G V + V Sbjct: 271 NFDKALNIQKGHVAAVMDVEFSPTGEELVSGSYDRTIRLWRRDAGHSRDVYHTKRMQRVF 330 Query: 224 SCDWHPEMGLIASASKDNLVKLW 246 W + I + S D V+LW Sbjct: 331 RTMWTMDSKYILTGSDDGNVRLW 353 >4AEZ-A nrPDB Length = 401 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 72/274 (26%), Positives = 116/274 (42%), Gaps = 29/274 (10%) Query: 119 LWNASSFTFETLMQAHDSA-VTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHT 177 +WNA S + L + +S V ++K+SHD ++ G +G++ I+ A H Sbjct: 117 VWNADSGSVSALAETDESTYVASVKWSHDGSFLSVGLGNGLVDIYDVESQTKLRTMAGHQ 176 Query: 178 ESI------RDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEM 231 + R + S + S + D ++I N G L GH +V W + Sbjct: 177 ARVGCLSWNRHVLSSGSRSGAIHHHD---VRIANHQIG----TLQGHSSEVCGLAWRSDG 229 Query: 232 GLIASASKDNLVKLWDPRSGNCISSILKFKHT-----VLKTRFQPTKGNLLM--AISKDK 284 +AS DN+V++WD R SSI KF T V + P + NLL + DK Sbjct: 230 LQLASGGNDNVVQIWDAR-----SSIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDK 284 Query: 285 SCRVFDIRYSMKELMCVRDETDYMTLEWHP-INESMFTLACYDGSLKHFDLLQNLNEPIL 343 ++ + + V + +L W P E M T D +L + + + Sbjct: 285 QIHFWNAATGAR-VNTVDAGSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQV 343 Query: 344 TIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 IP AHD + + +P G I +TAA D ++FW Sbjct: 344 DIP-AHDTRVLYSALSPDGRILSTAASDENLKFW 376 >5FL8-q nrPDB Length = 515 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 41/140 (29%), Positives = 62/140 (44%), Gaps = 1/140 (0%) Query: 108 LVVATYSGEFSLWNASSFTFETL-MQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNF 166 +V A+ LWN T M H V + +S D +++S D IK+W Sbjct: 374 MVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGRD 433 Query: 167 SMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCD 226 H S+ +A+SS+ V+CS D LK+W+ K L GH +V + D Sbjct: 434 GKFISTFRGHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDLPGHKDEVYTVD 493 Query: 227 WHPEMGLIASASKDNLVKLW 246 W + + S KD +V+LW Sbjct: 494 WSVDGKRVCSGGKDKMVRLW 513 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 59/286 (20%), Positives = 123/286 (43%), Gaps = 29/286 (10%) Query: 107 RLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQP-N 165 R+V +W+ + T ++ H + V + +S D + + +G D I++W P + Sbjct: 158 RMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKS 217 Query: 166 FSMVKEIDAAHTESIRDMAFS-------SNDSKFVTCSDDNILKIWNFSNGKQERVLSGH 218 + + H++ I +++ + + + S D +KIW+ + + +SGH Sbjct: 218 GQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMSGH 277 Query: 219 HWDVKSCDWHPEMGLIASASKDNLVKLWDPRS-GNCISSILKFKHTVLKTRFQPTKGNLL 277 V W + GL+ S S D V++WD S G CI+ + H V Sbjct: 278 TNSVSCVKWGGQ-GLLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNH----------- 325 Query: 278 MAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPI------NESMFTLACYDGSLKH 331 +++S D + R+ ++ K+ + + I +E M A D ++ Sbjct: 326 LSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFL 385 Query: 332 FDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 ++ L++ +PI + H K + ++++P G +A+ D +I+ W Sbjct: 386 WNPLKS-TKPIARMT-GHQKLVNHVAFSPDGRYIVSASFDNSIKLW 429 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 48/212 (22%), Positives = 86/212 (40%), Gaps = 55/212 (25%) Query: 174 AAHTESIRDMAFSSN-DSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMG 232 A H +I AF+ + S+ VT + DN +IW+ L GH+ V W P+ Sbjct: 140 AGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSWSPDGE 199 Query: 233 LIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIR 292 +IA+ S DN ++LWDP+SG C+ L Sbjct: 200 VIATGSMDNTIRLWDPKSGQCLGDAL---------------------------------- 225 Query: 293 YSMKELMCVRDETDYMT-LEWHPI------NESMFTLACYDGSLKHFDLLQNLNEPILTI 345 R + ++T L W PI ++ + DG++K +D + + + ++ Sbjct: 226 ---------RGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMS- 275 Query: 346 PYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 H ++ + + G +++ + DRT+R W Sbjct: 276 --GHTNSVSCVKWGGQGLLYS-GSHDRTVRVW 304 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 56/247 (22%), Positives = 98/247 (39%), Gaps = 43/247 (17%) Query: 107 RLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNF 166 RL ++ G +W+ S + M H ++V+ +K+ + SG D +++W N Sbjct: 250 RLASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQG-LLYSGSHDRTVRVWDINS 308 Query: 167 S------------MVKEIDAAHTESIRDMAFSSNDSK----------------------- 191 V + + ++R AF K Sbjct: 309 QGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNG 368 Query: 192 -----FVTCSDDNILKIWN-FSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKL 245 VT SDD + +WN + K ++GH V + P+ I SAS DN +KL Sbjct: 369 NSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKL 428 Query: 246 WDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDET 305 WD R G IS+ +V + + + LL++ SKD + +V+D+R + + Sbjct: 429 WDGRDGKFISTFRGHVASVYQVAWS-SDCRLLVSCSKDTTLKVWDVRTRKLSVDLPGHKD 487 Query: 306 DYMTLEW 312 + T++W Sbjct: 488 EVYTVDW 494 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 42/170 (24%), Positives = 76/170 (44%), Gaps = 11/170 (6%) Query: 131 MQAHDSAVTTMKYS-HDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSND 189 + H S + ++ H S M++G D +IW + H + +++S + Sbjct: 139 IAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSWSPDG 198 Query: 190 SKFVTCSDDNILKIWNFSNGK-QERVLSGHHWDVKSCDWHP-------EMGLIASASKDN 241 T S DN +++W+ +G+ L GH + S W P +AS+SKD Sbjct: 199 EVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDG 258 Query: 242 LVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDI 291 +K+WD S C ++ ++V ++ LL + S D++ RV+DI Sbjct: 259 TIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQ--GLLYSGSHDRTVRVWDI 306 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 39/150 (26%), Positives = 65/150 (43%), Gaps = 4/150 (2%) Query: 142 KYSHDSDWMISGDADGMIKIWQPNFSMVKEID--AAHTESIRDMAFSSNDSKFVTCSDDN 199 K + + M++ D + +W P K I H + + +AFS + V+ S DN Sbjct: 366 KNGNSEEMMVTASDDYTMFLWNP-LKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDN 424 Query: 200 ILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILK 259 +K+W+ +GK GH V W + L+ S SKD +K+WD R+ + Sbjct: 425 SIKLWDGRDGKFISTFRGHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDLPG 484 Query: 260 FKHTVLKTRFQPTKGNLLMAISKDKSCRVF 289 K V + G + + KDK R++ Sbjct: 485 HKDEVYTVDWS-VDGKRVCSGGKDKMVRLW 513 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 20/107 (18%), Positives = 50/107 (46%) Query: 99 IQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGM 158 + ++P+GR +V A++ LW+ F + + H ++V + +S D ++S D Sbjct: 408 VAFSPDGRYIVSASFDNSIKLWDGRDGKFISTFRGHVASVYQVAWSSDCRLLVSCSKDTT 467 Query: 159 IKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWN 205 +K+W + H + + + +S + + + D ++++W Sbjct: 468 LKVWDVRTRKLSVDLPGHKDEVYTVDWSVDGKRVCSGGKDKMVRLWT 514 >4V6W-Ag nrPDB Length = 318 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 54/240 (22%), Positives = 106/240 (44%), Gaps = 17/240 (7%) Query: 94 HVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISG 153 H I + + +G + ++ LW+ ++ + H V ++ +S D+ ++SG Sbjct: 65 HFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQIVSG 124 Query: 154 DADGMIKIW----QPNFSMVKEIDAAHTESIRDMAFSSNDSK--FVTCSDDNILKIWNFS 207 D IK+W + F++ ++ HT+ + + FS N S V+C D +K+WN + Sbjct: 125 SRDKTIKLWNTLAECKFTIQED---GHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLA 181 Query: 208 NGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKT 267 N K + GH+ + + P+ L S KD+ LWD G + + L+ + Sbjct: 182 NCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYT-LEHNDIINAL 240 Query: 268 RFQPTKGNLLMAISK-----DKSCR--VFDIRYSMKELMCVRDETDYMTLEWHPINESMF 320 F P + L +A D +C+ V ++R + D+ ++L W +++F Sbjct: 241 CFSPNRYWLCVAYGPSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTLF 300 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 62/269 (23%), Positives = 116/269 (43%), Gaps = 17/269 (6%) Query: 122 ASSFTFETLMQAHDSAVTTMKYS-HDSDWMISGDADGMIKIWQ------PNFSMVKEIDA 174 + + + H+ VT + + D D +IS D + +W+ N+ ++ Sbjct: 2 SETLQLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLY 61 Query: 175 AHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLI 234 H+ I D+ SS+ + ++ S D L++W+ + GK R GH DV S + + I Sbjct: 62 GHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQI 121 Query: 235 ASASKDNLVKLWDPRSGNCISSILKFKHT--VLKTRFQPTKGN-LLMAISKDKSCRVFDI 291 S S+D +KLW+ + C +I + HT V RF P N ++++ D++ +V+++ Sbjct: 122 VSGSRDKTIKLWNTLA-ECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNL 180 Query: 292 RYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDK 351 + K Y+ + + S C G LL +LN+ H+ Sbjct: 181 A-NCKLKNNHHGHNGYL----NTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLEHND 235 Query: 352 CITSLSYNPVGHIFATAAKDRTIRFWTRA 380 I +L ++P + A +I+ W A Sbjct: 236 IINALCFSP-NRYWLCVAYGPSIKIWDLA 263 Score = 51.6 bits (122), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 62/268 (23%), Positives = 110/268 (41%), Gaps = 37/268 (13%) Query: 131 MQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDS 190 + H ++ + S D ++ +SG D +++W HT+ + +AFS+++ Sbjct: 60 LYGHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNR 119 Query: 191 KFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSC-DWHPEMG--LIASASKDNLVKLWD 247 + V+ S D +K+WN + + H D SC + P +I S D VK+W+ Sbjct: 120 QIVSGSRDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWN 179 Query: 248 PRSGNCISSILKFKH----TVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRD 303 NC LK H L T G+L + KD ++D+ D Sbjct: 180 L--ANC---KLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDL----------ND 224 Query: 304 ETDYMTLEWHPINESM-------FTLACYDGSLKHFDL-----LQNLNEPILTIPYAHD- 350 + TLE + I ++ + Y S+K +DL ++ L +++ D Sbjct: 225 GKNLYTLEHNDIINALCFSPNRYWLCVAYGPSIKIWDLACKKTVEELRPEVVSPTSKADQ 284 Query: 351 -KCITSLSYNPVGHIFATAAKDRTIRFW 377 +C+ SL+++ G D TIR W Sbjct: 285 PQCL-SLAWSTDGQTLFAGYSDNTIRVW 311 >4V7E-Bg nrPDB Length = 380 Score = 64.7 bits (156), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 56/219 (25%), Positives = 94/219 (42%), Gaps = 17/219 (7%) Query: 131 MQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDS 190 +Q H V ++ ++ + +W++S DG + +W S H + + AF+ N Sbjct: 62 LQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWVMECAFAPNGQ 121 Query: 191 KFVTCSDDNILKIWNFS-------NGKQERVLSGHHWDVKSCDWHP--EMGLIASASKDN 241 D+ I+N S N RVL+GH SC + P E LI + S D Sbjct: 122 SVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLI-TGSGDQ 180 Query: 242 LVKLWDPRSGNCIS---SILKFKHT--VLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMK 296 LWD +G IS S HT VL N+ ++ S D + R++D+R + + Sbjct: 181 TCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRITSR 240 Query: 297 ELMCVRD-ETDYMTLEWHPINESMFTLACYDGSLKHFDL 334 + E D ++++ P + F DG+ + FD+ Sbjct: 241 AVRTYHGHEGDINSVKFFP-DGQRFGTGSDDGTCRLFDM 278 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 67/307 (21%), Positives = 123/307 (40%), Gaps = 29/307 (9%) Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDA 155 + ++ WTPE +V A+ G +WNA + ++ H V ++ + + G Sbjct: 69 VYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWVMECAFAPNGQSVACGGL 128 Query: 156 DGMIKIWQPNFSM-------VKEIDAAHTESIRDMAFS-SNDSKFVTCSDDNILKIWNFS 207 D I+ + V + H + +++ +T S D +W+ + Sbjct: 129 DSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVT 188 Query: 208 NGKQERVL-----SGHHWDVKSCDWHP-EMGLIASASKDNLVKLWDPR-SGNCISSILKF 260 G++ + SGH DV S + + S S D V+LWD R + + + Sbjct: 189 TGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRITSRAVRTYHGH 248 Query: 261 KHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMF 320 + + +F P G S D +CR+FD+R + +L E D E + F Sbjct: 249 EGDINSVKFFP-DGQRFGTGSDDGTCRLFDMR-TGHQLQVYNREPDRNDNELPIVTSVAF 306 Query: 321 TL------ACY-DGSLKHFDLLQNLNEPIL---TIPYAHDKCITSLSYNPVGHIFATAAK 370 ++ A Y +G +D L L E +L T+ +H+ I+ L + G T + Sbjct: 307 SISGRLLFAGYSNGDCYVWDTL--LAEMVLNLGTLQNSHEGRISCLGLSSDGSALCTGSW 364 Query: 371 DRTIRFW 377 D+ ++ W Sbjct: 365 DKNLKIW 371 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 50/216 (23%), Positives = 85/216 (39%), Gaps = 16/216 (7%) Query: 213 RVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPT 272 R L GH V S DW PE I SAS+D + +W+ + +I V++ F P Sbjct: 60 RTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWVMECAFAP- 118 Query: 273 KGNLLMAISKDKSCRVFDIRY------SMKELMCVRDETDYM-TLEWHPINESMFTLACY 325 G + D +C +F++ +M + Y + ++ P E+ Sbjct: 119 NGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSG 178 Query: 326 DGSLKHFDLLQNLNEPILT--IPYAHDKCITSLSYNPV-GHIFATAAKDRTIRFW---TR 379 D + +D+ I P H + SLS N + ++F + + D T+R W Sbjct: 179 DQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRIT 238 Query: 380 ARPIDPNAYDDPTYNNKKI--NGWFFGINNDINAVR 413 +R + + N+ K +G FG +D R Sbjct: 239 SRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCR 274 Score = 32.0 bits (71), Expect = 0.64, Method: Compositional matrix adjust. Identities = 22/78 (28%), Positives = 37/78 (47%), Gaps = 4/78 (5%) Query: 138 VTTMKYSHDSDWMISGDADGMIKIWQPNFS-MVKEIDA---AHTESIRDMAFSSNDSKFV 193 VT++ +S + +G ++G +W + MV + +H I + SS+ S Sbjct: 301 VTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQNSHEGRISCLGLSSDGSALC 360 Query: 194 TCSDDNILKIWNFSNGKQ 211 T S D LKIW FS ++ Sbjct: 361 TGSWDKNLKIWAFSGHRK 378 >5WYJ-BC nrPDB Length = 817 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 34/152 (22%), Positives = 72/152 (47%), Gaps = 2/152 (1%) Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDA 155 I A+ +P A+Y +WN + E + H + + + + + Sbjct: 494 INALSVSPNDSIFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQYDKLLATSSG 553 Query: 156 DGMIKIWQPN-FSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERV 214 D +KIW + FS++K ++ HT +++ +F + + ++C D ++KIW+ S+G+ + Sbjct: 554 DKTVKIWSLDTFSVMKTLEG-HTNAVQRCSFINKQKQLISCGADGLIKIWDCSSGECLKT 612 Query: 215 LSGHHWDVKSCDWHPEMGLIASASKDNLVKLW 246 L GH+ + + + +I SA D + + W Sbjct: 613 LDGHNNRLWALSTMNDGDMIVSADADGVFQFW 644 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 32/125 (25%), Positives = 54/125 (43%) Query: 133 AHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKF 192 AH+ + + S + + D KIW ++ A H + D++F D Sbjct: 489 AHEKDINALSVSPNDSIFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQYDKLL 548 Query: 193 VTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGN 252 T S D +KIW+ + L GH V+ C + + + S D L+K+WD SG Sbjct: 549 ATSSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWDCSSGE 608 Query: 253 CISSI 257 C+ ++ Sbjct: 609 CLKTL 613 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 57/276 (20%), Positives = 110/276 (39%), Gaps = 42/276 (15%) Query: 130 LMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVK-EIDA---AHTESIRDMAF 185 + + H+ + ++ + D W+ + D +W+ N + K +I A H+ ++ + Sbjct: 383 IYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGL 442 Query: 186 SSNDSK-----FVTCSDDNILKIWNFSN----------GKQERVLSGHHWDVKSCDWHPE 230 + SK +T S+D +K W E H D+ + P Sbjct: 443 PNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPN 502 Query: 231 MGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFD 290 + A+AS D K+W+ +G +++ K + F LL S DK+ ++ Sbjct: 503 DSIFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQYD-KLLATSSGDKTVKI-- 559 Query: 291 IRYSMKELMCVRDETDYMTLEWHP--------INESMFTLAC-YDGSLKHFDLLQNLNEP 341 +S+ ++ TLE H IN+ ++C DG +K +D + E Sbjct: 560 --WSLDTFSVMK------TLEGHTNAVQRCSFINKQKQLISCGADGLIKIWDC--SSGEC 609 Query: 342 ILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 + T+ H+ + +LS G + +A D +FW Sbjct: 610 LKTLD-GHNNRLWALSTMNDGDMIVSADADGVFQFW 644 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 42/180 (23%), Positives = 72/180 (40%), Gaps = 21/180 (11%) Query: 83 KFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMK 142 K H SN+ + I A++ TP+G+ L TY + L F +T +++ Sbjct: 51 KILHKISNEDEQEITALKLTPDGQYL---TYVSQAQLLKI--FHLKTGKVVRSMKISSPS 105 Query: 143 YSHDSD----WMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSS--NDSKFVTCS 196 Y D+D + G DG I + + H +I + F N ++ S Sbjct: 106 YILDADSTSTLLAVGGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLAS 165 Query: 197 DD--NILKIWNFSNGKQERVLSGHHWDVKSCDW-------HPEMGLIASASKDNLVKLWD 247 D ++K+W+ K L H V+ D P + L+ S +D+++ LWD Sbjct: 166 GDTNGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLL-SGGRDDIINLWD 224 Score = 37.4 bits (85), Expect = 0.015, Method: Compositional matrix adjust. Identities = 59/280 (21%), Positives = 110/280 (39%), Gaps = 39/280 (13%) Query: 132 QAHDSAVTTMKYSHDSD---WMI-SGDADGMIKIWQPNFSMVKEIDAAHTESIRDM---A 184 + H ++++K+ + W++ SGD +GM+K+W HT ++R + Sbjct: 141 KGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIE 200 Query: 185 FSSNDS---KFVTCSDDNILKIWNFSNGKQERVLSGH--HWDVKSCDWHPEMG---LIAS 236 ND ++ D+I+ +W+F+ K+ ++L + V+SC + + +I + Sbjct: 201 VPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLLKTLPVNQQVESCGFLKDGDGKRIIYT 260 Query: 237 ASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLM-AISKDKSCRVFDIRYSM 295 A D + +L D SG+ + K + P N M + D++ ++ ++ + Sbjct: 261 AGGDAIFQLIDSESGSVLKRTNKPIEELFIIGVLPILSNSQMFLVLSDQTLQLINVEEDL 320 Query: 296 KELMCVRDETDYMTLEWHPINESMFTLACYDG-SLKHFDLLQN-----------LNEPIL 343 K DE N + Y G L L N L+ P Sbjct: 321 K-----NDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIPVPDLSGPEA 375 Query: 344 TIPY------AHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 ++P H+ + SL G ATA+KD T W Sbjct: 376 SLPLDVEIYEGHEDLLNSLDATEDGLWIATASKDNTAIVW 415 Score = 35.8 bits (81), Expect = 0.044, Method: Compositional matrix adjust. Identities = 14/58 (24%), Positives = 30/58 (51%) Query: 106 RRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ 163 ++L+ G +W+ SS + H++ + + +D D ++S DADG+ + W+ Sbjct: 588 KQLISCGADGLIKIWDCSSGECLKTLDGHNNRLWALSTMNDGDMIVSADADGVFQFWK 645 Score = 35.0 bits (79), Expect = 0.072, Method: Compositional matrix adjust. Identities = 46/184 (25%), Positives = 78/184 (42%), Gaps = 22/184 (11%) Query: 213 RVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILK--FKHTVLKTRFQ 270 + GH + S D + IA+ASKDN +W +C I H+ T Sbjct: 382 EIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVG 441 Query: 271 ----PTKG--NLLMAISKDKSCRVFDI---RYSMK-ELMCVRD------ETDYMTLEWHP 314 +KG L+ S D + + + I SM +++ V + E D L P Sbjct: 442 LPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSP 501 Query: 315 INESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTI 374 N+S+F A YD + K ++L E L H + + +S+ + AT++ D+T+ Sbjct: 502 -NDSIFATASYDKTCKIWNLENGELEATLA---NHKRGLWDVSFCQYDKLLATSSGDKTV 557 Query: 375 RFWT 378 + W+ Sbjct: 558 KIWS 561 >6GMH-W nrPDB Length = 305 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 56/243 (23%), Positives = 108/243 (44%), Gaps = 13/243 (5%) Query: 54 VVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHV--IPAIQWT----PEGRR 107 VV + S+T+ I ++ R+ +L + ++K + P WT P+ + Sbjct: 67 VVSVDISHTLPIAASSSLDAHIRLWDLEN------GKQIKSIDAGPVDAWTLAFSPDSQY 120 Query: 108 LVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFS 167 L T+ G+ +++ S E + + ++ YS D ++ SG DG+I I+ Sbjct: 121 LATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATG 180 Query: 168 MVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDW 227 + H IR + FS + VT SDD +KI++ + LSGH V + + Sbjct: 181 KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAF 240 Query: 228 HPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCR 287 P+ S+S D VK+WD + C+ + + V ++ G+ ++++ D+ Sbjct: 241 CPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNG-NGSKIVSVGDDQEIH 299 Query: 288 VFD 290 ++D Sbjct: 300 IYD 302 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 53/221 (23%), Positives = 96/221 (43%), Gaps = 17/221 (7%) Query: 166 FSMVKEIDAAHTESIRDMAFSSNDSK----FVTCSDDNILKIWNFSNGKQERV-----LS 216 + ++ + + AH ++I +A+ +N + VT S D+++K+W + + ER+ L Sbjct: 5 YGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKW---RDERLDLQWSLE 61 Query: 217 GHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNL 276 GH V S D + + AS+S D ++LWD +G I SI F P L Sbjct: 62 GHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYL 121 Query: 277 LMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQ 336 K +F + KE +++ + P + + + A DG + FD+ Sbjct: 122 ATGTHVGK-VNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAI-DGIINIFDIAT 179 Query: 337 NLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 +L H I SL+++P + TA+ D I+ + Sbjct: 180 G---KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIY 217 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 37/176 (21%), Positives = 76/176 (43%), Gaps = 3/176 (1%) Query: 120 WNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ-PNFSMVKEIDAAHTE 178 W + ++ H V ++ SH S D I++W N +K IDA + Sbjct: 49 WRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVD 108 Query: 179 SIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASAS 238 + +AFS + T + + I+ +GK+E L + S + P+ +AS + Sbjct: 109 AWT-LAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGA 167 Query: 239 KDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYS 294 D ++ ++D +G + ++ + F P LL+ S D +++D++++ Sbjct: 168 IDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDS-QLLVTASDDGYIKIYDVQHA 222 >3ACP-A nrPDB Length = 417 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 40/125 (32%), Positives = 58/125 (46%), Gaps = 2/125 (1%) Query: 130 LMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSND 189 L +A +AV T K I G +G IK+ NF++ +EID AH I + F + Sbjct: 91 LKRADYTAVDTAKLQMRR--FILGTTEGDIKVLDSNFNLQREIDQAHVSEITKLKFFPSG 148 Query: 190 SKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPR 249 ++ S D LKIW+ +G R L GH V + SAS D ++LW+ Sbjct: 149 EALISSSQDMQLKIWSVKDGSNPRTLIGHRATVTDIAIIDRGRNVLSASLDGTIRLWECG 208 Query: 250 SGNCI 254 +G I Sbjct: 209 TGTTI 213 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 23/104 (22%), Positives = 45/104 (43%) Query: 106 RRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPN 165 RR ++ T G+ + +++ + QAH S +T +K+ + +IS D +KIW Sbjct: 107 RRFILGTTEGDIKVLDSNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVK 166 Query: 166 FSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNG 209 H ++ D+A ++ S D +++W G Sbjct: 167 DGSNPRTLIGHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTG 210 Score = 32.7 bits (73), Expect = 0.33, Method: Compositional matrix adjust. Identities = 19/73 (26%), Positives = 32/73 (43%), Gaps = 3/73 (4%) Query: 306 DYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIF 365 DY ++ + F L +G +K D NL I AH IT L + P G Sbjct: 95 DYTAVDTAKLQMRRFILGTTEGDIKVLDSNFNLQREI---DQAHVSEITKLKFFPSGEAL 151 Query: 366 ATAAKDRTIRFWT 378 ++++D ++ W+ Sbjct: 152 ISSSQDMQLKIWS 164 Score = 30.0 bits (66), Expect = 2.2, Method: Compositional matrix adjust. Identities = 13/68 (19%), Positives = 31/68 (45%) Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDA 155 I +++ P G L+ ++ + +W+ + + H + VT + ++S Sbjct: 139 ITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTLIGHRATVTDIAIIDRGRNVLSASL 198 Query: 156 DGMIKIWQ 163 DG I++W+ Sbjct: 199 DGTIRLWE 206 Score = 28.1 bits (61), Expect = 8.9, Method: Compositional matrix adjust. Identities = 19/100 (19%), Positives = 47/100 (47%), Gaps = 1/100 (1%) Query: 191 KFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRS 250 +F+ + + +K+ + + Q + H ++ + P + S+S+D +K+W + Sbjct: 108 RFILGTTEGDIKVLDSNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKD 167 Query: 251 GNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFD 290 G+ +++ + TV N+L A S D + R+++ Sbjct: 168 GSNPRTLIGHRATVTDIAIIDRGRNVLSA-SLDGTIRLWE 206 >2HES-X nrPDB Length = 330 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 47/171 (27%), Positives = 79/171 (46%), Gaps = 14/171 (8%) Query: 133 AHDSAVTTMKYSHDSDWMISGDADGMIKIWQPN------FSM-VKEIDAAHTESIRDMAF 185 AH A+ ++ + + + +G D + IW F M + I H ++ +A+ Sbjct: 56 AHKKAIRSVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAW 115 Query: 186 SSNDSKFVTCSDDNILKIWNFSNGKQE----RVLSGHHWDVKSCDWHPEMGLIASASKDN 241 S++ TCS D + IW +E VL H DVK WHP L+AS+S D+ Sbjct: 116 SNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDD 175 Query: 242 LVKLWDPRSGN--CISSILKFKHTVLKTRFQPTKGNL-LMAISKDKSCRVF 289 V++W + C++ + + TV + F T+G L + S D + RV+ Sbjct: 176 TVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVW 226 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 36/168 (21%), Positives = 73/168 (43%), Gaps = 14/168 (8%) Query: 222 VKSCDWHPEMGLIASASKDNLVKLW------DPRSGNCISSILKFKHTVLKTRFQPTKGN 275 ++S W P L+A+ S D+ V +W D + +I++ +K G Sbjct: 61 IRSVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGY 120 Query: 276 LLMAISKDKSCRVFDIRYSMKELMCV----RDETDYMTLEWHPINESMFTLACYDGSLKH 331 L S+DKS +++ S +E C+ D + WHP +E++ + YD +++ Sbjct: 121 YLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHP-SEALLASSSYDDTVRI 179 Query: 332 FDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIF--ATAAKDRTIRFW 377 + + E + + H+ + S ++ +F + + D T+R W Sbjct: 180 WKDYDDDWECVAVLN-GHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVW 226 >5NZU-C nrPDB Length = 905 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 46/231 (19%), Positives = 101/231 (43%), Gaps = 5/231 (2%) Query: 149 WMISGDADGMIKIW-QPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFS 207 WM++ +G + +W ++VK + +R F + + VT +DD ++++N++ Sbjct: 29 WMLASLYNGSVCVWNHETQTLVKTFEVCDL-PVRAAKFVARKNWVVTGADDMQIRVFNYN 87 Query: 208 NGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWD-PRSGNCISSILKFKHTVLK 266 ++ + H ++ HP I ++S D L+KLWD + +C H V++ Sbjct: 88 TLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQ 147 Query: 267 TRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYD 326 P N + S D++ +V+ + S E ++++ + + ++ D Sbjct: 148 IVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGAD 207 Query: 327 GSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 L + N+ + H + ++ S++P I T ++D T+R W Sbjct: 208 DRL--VKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIW 256 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 31/108 (28%), Positives = 56/108 (51%), Gaps = 12/108 (11%) Query: 146 DSDWMISGDADGMIKIWQ-----PNFSMVKEIDAAHTESIRDMAFSSNDSK--FVTCSDD 198 D++ S D IK+WQ PNF++ H + + + + S K ++ +DD Sbjct: 154 DNNQFASASLDRTIKVWQLGSSSPNFTL-----EGHEKGVNCIDYYSGGDKPYLISGADD 208 Query: 199 NILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW 246 ++KIW++ N + L GH +V +HPE+ +I + S+D V++W Sbjct: 209 RLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIW 256 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 49/249 (19%), Positives = 98/249 (39%), Gaps = 56/249 (22%) Query: 108 LVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFS 167 ++ + Y+G +WN + T + D V K+ +W+++G D I+++ N Sbjct: 30 MLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTL 89 Query: 168 MVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWN---------------------- 205 + AH++ IR +A +T SDD ++K+W+ Sbjct: 90 ERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIV 149 Query: 206 --------FSNGKQER--------------VLSGHHWDVKSCDWHP--EMGLIASASKDN 241 F++ +R L GH V D++ + + S + D Sbjct: 150 INPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDR 209 Query: 242 LVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVF---------DIR 292 LVK+WD ++ C+ ++ V F P + +++ S+D + R++ + Sbjct: 210 LVKIWDYQNKTCVQTLEGHAQNVSCASFHP-ELPIIITGSEDGTVRIWHSSTYRLESTLN 268 Query: 293 YSMKELMCV 301 Y M+ + CV Sbjct: 269 YGMERVWCV 277 >4BTS-AR nrPDB Length = 343 Score = 61.6 bits (148), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 66/263 (25%), Positives = 101/263 (38%), Gaps = 53/263 (20%) Query: 130 LMQAHDSAVTTM------KYSHDSDWMISGDADGMIKIWQ-------PNFSMVKEIDAAH 176 +++ H VT++ K + DS +ISG D + IW+ F + + H Sbjct: 16 ILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGH 75 Query: 177 TESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIAS 236 + D+A S + ++ S D L++W+ G + GH +V S + P+ I S Sbjct: 76 NHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSPDNRQILS 135 Query: 237 ASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYS-- 294 A + +KLW+ SS K H S SC +RYS Sbjct: 136 AGAEREIKLWNILGECKFSSAEKENH------------------SDWVSC----VRYSPI 173 Query: 295 MKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCIT 354 MK V+ Y F +DG LK + N N I AH+ + Sbjct: 174 MKSANKVQPFAPY------------FASVGWDGRLK----VWNTNFQIRYTFKAHESNVN 217 Query: 355 SLSYNPVGHIFATAAKDRTIRFW 377 LS +P G AT KD+ + W Sbjct: 218 HLSISPNGKYIATGGKDKKLLIW 240 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 52/271 (19%), Positives = 102/271 (37%), Gaps = 29/271 (10%) Query: 94 HVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISG 153 H + + + E + +++ LW+ + T H S V ++ +S D+ ++S Sbjct: 77 HFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSPDNRQILSA 136 Query: 154 DADGMIKIW----QPNFSMV-KEIDAAHTESIRDMAFSSNDSK-------FVTCSDDNIL 201 A+ IK+W + FS KE + +R + +K F + D L Sbjct: 137 GAEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRL 196 Query: 202 KIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFK 261 K+WN +N + H +V P IA+ KD + +WD + Sbjct: 197 KVWN-TNFQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKLLIWDILNLTYPQREFDAG 255 Query: 262 HTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDET-------------DYM 308 T+ + F P +A+ D+ ++F++ K +C + Sbjct: 256 STINQIAFNPKL--QWVAVGTDQGVKIFNLMTQSKAPVCTIEAEPITKAEGQKGKNPQCT 313 Query: 309 TLEWHPINESMFTLACYDGSLKHFDLLQNLN 339 +L W+ + + +F DG ++ F + N Sbjct: 314 SLAWNALGKKLFA-GFTDGVIRTFSFETSAN 343 >6QX9-5O nrPDB Length = 357 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 61/267 (22%), Positives = 115/267 (43%), Gaps = 21/267 (7%) Query: 130 LMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ-----PNFSMVKEIDAAHTESIRDMA 184 L+ H+ V K+ + + S D +I +W N++ +K H+ ++ ++ Sbjct: 61 LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLK----GHSGAVMELH 116 Query: 185 FSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMG--LIASASKDNL 242 ++++ S + S D + +W+ G++ + L GH V SC + G L+ + S D Sbjct: 117 YNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSC-YPARRGPQLVCTGSDDGT 175 Query: 243 VKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVR 302 VKLWD R I + + + VL F T ++ D +V+D+R + K +R Sbjct: 176 VKLWDIRKKAAIQT-FQNTYQVLAVTFNDTSDQIISG-GIDNDIKVWDLRQN-KLTYTMR 232 Query: 303 DETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNL-NEPILTI----PYAHDKCITSLS 357 D +T S D +++ +D+ E + I + +K + S Sbjct: 233 GHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCS 292 Query: 358 YNPVGHIFATAAKDRTIRFW-TRARPI 383 ++P G A + DR + W T +R I Sbjct: 293 WSPDGSKIAAGSADRFVYVWDTTSRRI 319 Score = 58.2 bits (139), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 45/190 (23%), Positives = 86/190 (45%), Gaps = 18/190 (9%) Query: 115 GEFSLWN----ASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVK 170 G LW+ A+ TF+ Q V + ++ SD +ISG D IK+W + + Sbjct: 174 GTVKLWDIRKKAAIQTFQNTYQ-----VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLT 228 Query: 171 EIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSN-GKQERVLSGHHWDVKS----- 224 H +S+ ++ SS S ++ + DN +++W+ +ER + +V + Sbjct: 229 YTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNL 288 Query: 225 --CDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISK 282 C W P+ IA+ S D V +WD S + + ++ + F P + ++++ S Sbjct: 289 LRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDE-PIIISASS 347 Query: 283 DKSCRVFDIR 292 DK + +I+ Sbjct: 348 DKRLYMGEIQ 357 >5L9T-R nrPDB Length = 493 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 59/291 (20%), Positives = 116/291 (39%), Gaps = 61/291 (20%) Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDA 155 + ++ W+ G + V T+ G +W+A++ ++++ H + V + + +++ + SG Sbjct: 232 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW--NAEQLSSGSR 289 Query: 156 DGMI---KIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQE 212 D MI I P + + H + + + +S++ + +DN L +WN S+ Sbjct: 290 DRMILQRDIRTPPLQSERRLQ-GHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPV 348 Query: 213 RVLSGHHWDVKSCDWHP-EMGLIAS--ASKDNLVKLWDPRSGNCISSILKFKHTVLKTRF 269 + + H VK+ W P + GL+AS + D ++ W+ +G + I Sbjct: 349 QQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCI------------ 396 Query: 270 QPTKGNLLMAISKDKSCRVFDIRYS--MKELMCVRDETDYMTLEW-HPINESMFTLACYD 326 D +V ++ +S EL+ + L W +P S+ +A Sbjct: 397 -------------DTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYP---SLTQVAKLT 440 Query: 327 GSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 G H + L+ +P G T A D T+RFW Sbjct: 441 G---------------------HSYRVLYLAMSPDGEAIVTGAGDETLRFW 470 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 36/162 (22%), Positives = 73/162 (45%), Gaps = 10/162 (6%) Query: 93 KHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYS-HDSDWMI 151 + + ++W+ + + L + +WN SS + H +AV + +S H + Sbjct: 313 RQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLA 372 Query: 152 SGD--ADGMIKIWQPNFSMVKEIDAAHTES-IRDMAFSSNDSKFVTC---SDDNILKIWN 205 SG AD I+ W N + + T S + ++A+S + ++ V+ S + IL +W Sbjct: 373 SGGGTADRCIRFW--NTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQIL-VWK 429 Query: 206 FSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWD 247 + + Q L+GH + V P+ I + + D ++ W+ Sbjct: 430 YPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 471 >5K1B-B nrPDB Length = 677 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 55/239 (23%), Positives = 100/239 (41%), Gaps = 21/239 (8%) Query: 150 MISGDADGMIKIWQPNFSMVKEIDAA---HTESIRDMAFSSNDSKFVTCSDDNILKIWNF 206 + + D +I+IW N A+ HT+ + D+ N ++ S D +K+WN Sbjct: 45 LFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNA 104 Query: 207 SNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLK 266 G L H VK+ + + L+ASA D + LWD N ++++ +TV Sbjct: 105 HKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDV---NTLTALTASNNTVTT 161 Query: 267 TRFQPTK-----------GNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPI 315 + K G ++++ S +K RV+D R K LM ++ TD + Sbjct: 162 SSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAK-LMKLKGHTDNVKALLLNR 220 Query: 316 NESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTI 374 + + DG+++ + L Q + + HD+ + +L N + +DR I Sbjct: 221 DGTQCLSGSSDGTIRLWSLGQ---QRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKI 276 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 47/236 (19%), Positives = 100/236 (42%), Gaps = 33/236 (13%) Query: 163 QPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSG--HHW 220 Q ++ + E++ + + + ++ T D+I++IW+ + KQ+ ++ HH Sbjct: 16 QVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHH- 74 Query: 221 DVKSCDWHPEMGL------IASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKG 274 DW ++ L + SAS D VK+W+ G C+S++ K V + K Sbjct: 75 ----TDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDK- 129 Query: 275 NLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYD-GSLKHFD 333 L+ + D+ ++D+ ++ L + +L + +S+++LA G++ Sbjct: 130 ELVASAGLDRQIFLWDVN-TLTALTASNNTVTTSSLSGN--KDSIYSLAMNQLGTI---- 182 Query: 334 LLQNLNEPILTI-----------PYAHDKCITSLSYNPVGHIFATAAKDRTIRFWT 378 ++ E +L + H + +L N G + + D TIR W+ Sbjct: 183 IVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWS 238 >5GAN-H nrPDB Length = 465 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 73/319 (22%), Positives = 129/319 (40%), Gaps = 32/319 (10%) Query: 76 RVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHD 135 R+ NL + L S K I A+ + + + +++G+ + N S T + L Q D Sbjct: 161 RMANLELAGSQLVSTKP---ISAVSLSTDDMVVATGSWAGDLQVLN--SQTLQPLTQKLD 215 Query: 136 SAVTTMK----YSHDSDWMISGDADGMIKIWQ-----PNFSMVKEIDAAHTESIRDMAFS 186 S V + + ++ MIS DG+IK +Q ++ ++ H I D+ + Sbjct: 216 SHVGKIGAIDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDL-VGHERRISDVKYH 274 Query: 187 SNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW 246 + + S D ++W+ S ++ + GH V S + + L+ S D+L LW Sbjct: 275 PSGKFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLW 334 Query: 247 DPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETD 306 D RSG+ + ++ + + P G + D V+DIR RDE Sbjct: 335 DIRSGSKVMTLAGHSKPIYTVAWSPN-GYQVATGGGDGIINVWDIRK--------RDEGQ 385 Query: 307 YMTLEWHPINESMFTLACYDGSLK----HFDLLQNL--NEPILTIP--YAHDKCITSLSY 358 + H + + DG K +D L N+ ++ L + H I SL Sbjct: 386 LNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSLAGHTDKIISLDI 445 Query: 359 NPVGHIFATAAKDRTIRFW 377 + H + DR+I+ W Sbjct: 446 SNNSHFLVSGGWDRSIKLW 464 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 32/134 (23%), Positives = 61/134 (45%), Gaps = 6/134 (4%) Query: 119 LWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIW---QPNFSMVKEIDAA 175 LW+ S + + H + T+ +S + + +G DG+I +W + + + +I A Sbjct: 333 LWDIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQI-LA 391 Query: 176 HTESIRDMAFSSNDS--KFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGL 233 H + + FS D K V+C DN++ +++ + L+GH + S D Sbjct: 392 HRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSLAGHTDKIISLDISNNSHF 451 Query: 234 IASASKDNLVKLWD 247 + S D +KLW+ Sbjct: 452 LVSGGWDRSIKLWN 465 Score = 33.9 bits (76), Expect = 0.16, Method: Compositional matrix adjust. Identities = 23/106 (21%), Positives = 55/106 (51%), Gaps = 11/106 (10%) Query: 68 PNAYR----GRDRVINL--PSKFTHLSSNKV---KHVIPAIQWTPE--GRRLVVATYSGE 116 PN Y+ G D +IN+ K N++ ++++ ++++ E G++LV Y Sbjct: 359 PNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNL 418 Query: 117 FSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIW 162 +++++ ++ + H + ++ S++S +++SG D IK+W Sbjct: 419 INVYSSDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLW 464 >3ODT-A nrPDB Length = 313 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 38/135 (28%), Positives = 66/135 (48%), Gaps = 6/135 (4%) Query: 119 LWNASSFTFETLMQAHDSAVTTMKY-SHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHT 177 +W S + +QAH+++V K S + ++ AD IK+WQ N ++K H Sbjct: 128 VWKEGSLVYN--LQAHNASVWDAKVVSFSENKFLTASADKTIKLWQ-NDKVIKTFSGIHN 184 Query: 178 ESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASA 237 + +R +A +D F++CS+D ++K+ + G R GH V P G I S Sbjct: 185 DVVRHLAVV-DDGHFISCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPN-GDIVSC 242 Query: 238 SKDNLVKLWDPRSGN 252 +D V++W +G+ Sbjct: 243 GEDRTVRIWSKENGS 257 >6HHQ-h nrPDB Length = 319 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 45/207 (21%), Positives = 84/207 (40%), Gaps = 44/207 (21%) Query: 175 AHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLI 234 H+ ++D +++ + ++ S D L++W+ + G+ + GH DV S D + +I Sbjct: 63 GHSHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMI 122 Query: 235 ASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYS 294 S S+D +K+W + G C++++L V + R P + + D S + Sbjct: 123 ISGSRDKTIKVWTIK-GQCLATLLGHNDWVSQVRVVPNEK------ADDDSVTI------ 169 Query: 295 MKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPY-AHDKCI 353 + D M W NLN+ + + H+ I Sbjct: 170 ------ISAGNDKMVKAW------------------------NLNQFQIEADFIGHNSNI 199 Query: 354 TSLSYNPVGHIFATAAKDRTIRFWTRA 380 +L+ +P G + A+A KD I W A Sbjct: 200 NTLTASPDGTLIASAGKDGEIMLWNLA 226 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 57/284 (20%), Positives = 111/284 (39%), Gaps = 21/284 (7%) Query: 49 GLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRL 108 G PNL++ T + G D+ +P + S H++ T +G Sbjct: 28 GQPNLLLSASRDKT---LISWKLTGDDQKFGVPVR----SFKGHSHIVQDCTLTADGAYA 80 Query: 109 VVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSM 168 + A++ LW+ ++ H S V ++ + +ISG D IK+W Sbjct: 81 LSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIISGSRDKTIKVWTIKGQC 140 Query: 169 VKEIDAAHTESIRDMAFSSNDSK------FVTCSDDNILKIWNFSNGKQERVLSGHHWDV 222 + + H + + + N+ ++ +D ++K WN + + E GH+ ++ Sbjct: 141 LATL-LGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQIEADFIGHNSNI 199 Query: 223 KSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISK 282 + P+ LIASA KD + LW+ + + + L + V F P + L A + Sbjct: 200 NTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYT-LSAQDEVFSLAFSPNRYWLAAATAT 258 Query: 283 DKSCRVFDIRYSMKEL------MCVRDETDYMTLEWHPINESMF 320 D +Y + +L E ++L W +++F Sbjct: 259 GIKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTLF 302 >5G04-R nrPDB Length = 499 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 67/328 (20%), Positives = 134/328 (40%), Gaps = 18/328 (5%) Query: 68 PNAYRGRDRVI-NLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFT 126 P + R R I +LP + + + + + W+ G L VA + + LW+ASS Sbjct: 158 PGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWS-SGNVLAVALDNSVY-LWSASSGD 215 Query: 127 FETLMQAHDSA--VTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMA 184 L+Q ++++ + + +++ G + +++W + K + + S R + Sbjct: 216 ILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLW--DVQQQKRLRNMTSHSARVGS 273 Query: 185 FSSNDSKFVTCSDDNILKIWNFSNGKQE-RVLSGHHWDVKSCDWHPEMGLIASASKDNLV 243 S N + S + + + LSGH +V W P+ +AS DNLV Sbjct: 274 LSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLV 333 Query: 244 KLWDPRSGNC----ISSILKFKHTVLKTRFQPTKGNLLM--AISKDKSCRVFDIRYSMKE 297 +W G + + + + V + P + N+L + D+ R++++ S Sbjct: 334 NVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV-CSGAC 392 Query: 298 LMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLS 357 L V + ++ W P + + + + + + + + H + SL+ Sbjct: 393 LSAVDAHSQVCSILWSPHYKELISGHGF--AQNQLVIWKYPTMAKVAELKGHTSRVLSLT 450 Query: 358 YNPVGHIFATAAKDRTIRFWTRARPIDP 385 +P G A+AA D T+R W R +DP Sbjct: 451 MSPDGATVASAAADETLRLW-RCFELDP 477 >3JAP-g nrPDB Length = 326 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 38/147 (25%), Positives = 67/147 (45%), Gaps = 7/147 (4%) Query: 131 MQAHDSAVTTMKYSHDS-DWMISGDADGMIKIW-----QPNFSMVKEIDAAHTESIRDMA 184 ++ H+ VT++ S + ++SG D + W + F + H+ ++D+ Sbjct: 14 LEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDVV 73 Query: 185 FSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVK 244 S++ + V+ S D L++WN + G E GH DV S I SAS+D ++ Sbjct: 74 VSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIISASRDKTIR 133 Query: 245 LWDPRSGNCISSILKFKHTVLKTRFQP 271 +W+ G+C +L V K R P Sbjct: 134 VWNT-VGDCAYVLLGHTDWVTKVRVAP 159 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 44/213 (20%), Positives = 85/213 (39%), Gaps = 20/213 (9%) Query: 94 HVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISG 153 H++ + + +G V A++ LWN ++ E H V ++ +S +IS Sbjct: 67 HIVQDVVVSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIISA 126 Query: 154 DADGMIKIWQPNFSMVKEIDAAHTE----------SIRDMAFSSNDSKFVTCSDDNILKI 203 D I++W + HT+ ++ D FV+ D I++ Sbjct: 127 SRDKTIRVWN-TVGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRS 185 Query: 204 WNFSNG--KQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKF- 260 W+ + + E GH+ + P+ L ASA KD + +W+ + S+ + F Sbjct: 186 WSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHK---SAFMNFD 242 Query: 261 -KHTVLKTRFQPTKGNLLMAISKDKSCRVFDIR 292 K V F P++ L A + +++D+ Sbjct: 243 AKDEVFALAFSPSRFWLTAATA--SGIKIYDLE 273 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 48/204 (23%), Positives = 82/204 (40%), Gaps = 25/204 (12%) Query: 192 FVTCSDDNILKIWNFSNGKQE-----RVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW 246 V+ S D L W + +Q+ R GH V+ + SAS D ++LW Sbjct: 34 LVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDVVVSADGNYAVSASWDKTLRLW 93 Query: 247 DPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETD 306 + +GN + + VL ++ A S+DK+ RV++ ++ TD Sbjct: 94 NLATGNSEARFVGHTGDVLSVAIDANSSKIISA-SRDKTIRVWNTVGDCAYVLL--GHTD 150 Query: 307 YMT--------LEWHPINESMFTL--ACYDGSLKHFDLLQNLNEPILTIP---YAHDKCI 353 ++T LE +++ T A D ++ + +LNE I H+ I Sbjct: 151 WVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSW----SLNEDSYRIEADFIGHNNYI 206 Query: 354 TSLSYNPVGHIFATAAKDRTIRFW 377 + +P G + A+A KD I W Sbjct: 207 NVVQPSPDGSLAASAGKDGQIYVW 230 >4GGA-A nrPDB Length = 420 Score = 54.7 bits (130), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 68/328 (20%), Positives = 135/328 (41%), Gaps = 18/328 (5%) Query: 68 PNAYRGRDRVI-NLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFT 126 P + R R I +LP + + + + + W+ G L VA + + LW+ASS Sbjct: 79 PGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWS-SGNVLAVALDNSVY-LWSASSGD 136 Query: 127 FETLMQAHDSA--VTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMA 184 L+Q ++++ + + +++ G + +++W + K + + S R + Sbjct: 137 ILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLW--DVQQQKRLRNMTSHSARVGS 194 Query: 185 FSSNDSKFVTCSDDNILKIWNFSNGKQE-RVLSGHHWDVKSCDWHPEMGLIASASKDNLV 243 S N + S + + + LSGH +V W P+ +AS DNLV Sbjct: 195 LSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLV 254 Query: 244 KLW--DPRSGNCI--SSILKFKHTVLKTRFQPTKGNLLM--AISKDKSCRVFDIRYSMKE 297 +W P G + + + + V + P + N+L + D+ R++++ S Sbjct: 255 NVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV-CSGAC 313 Query: 298 LMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLS 357 L V + ++ W P + + + + + + + + H + SL+ Sbjct: 314 LSAVDAHSQVCSILWSPHYKELISGHGF--AQNQLVIWKYPTMAKVAELKGHTSRVLSLT 371 Query: 358 YNPVGHIFATAAKDRTIRFWTRARPIDP 385 +P G A+AA D T+R W R +DP Sbjct: 372 MSPDGATVASAAADETLRLW-RCFELDP 398 >4G56-B nrPDB Length = 357 Score = 54.7 bits (130), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 61/253 (24%), Positives = 107/253 (42%), Gaps = 22/253 (8%) Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLM------QAHDSAVTTMKYSHDSDW 149 + + W E + ++VA+ SG LW E+L+ HD V T+ D Sbjct: 97 VTDVAWVSE-KGILVASDSGAVELWEI--LEKESLLVNKFAKYEHDDIVKTLSVFSDGTQ 153 Query: 150 MISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFS-SNDSKFVTCSDDNILKIWNFSN 208 +SG D +K+W + V + AH+ + +A D+ F++C +D + +W+ Sbjct: 154 AVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTRK 213 Query: 209 GKQERVLSGHHWDV--KSCDWHPEMGLIASASKD----NLVKLWDPRSGNCISSILKFKH 262 K + D S WHPE + + +LV + +P S S++ Sbjct: 214 PKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLVNIKNPDSAQ-TSAVHSQNI 272 Query: 263 TVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMT-LEWHPINESMFT 321 T L + + L +IS+D + V D +S E+ D++T + W P++ S FT Sbjct: 273 TGLAYSYHSSP--FLASISEDCTVAVLDADFS--EVFRDLSHRDFVTGVAWSPLDHSKFT 328 Query: 322 LACYDGSLKHFDL 334 +D + H L Sbjct: 329 TVGWDHKVLHHHL 341 >5WYJ-BE nrPDB Length = 939 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 44/185 (23%), Positives = 81/185 (43%), Gaps = 9/185 (4%) Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDA 155 + ++ + G + + +G +++N S + H AVT + + M+S Sbjct: 463 VKSVAMSQCGNFGFIGSSNGSITIYNMQSGILRKKYKLHKRAVTGISLDGMNRKMVSCGL 522 Query: 156 DGMIKIWQPNFSMVK---EIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQE 212 DG++ + N S + ++DA I M + + F DD + + + + Sbjct: 523 DGIVGFYDFNKSTLLGKLKLDAP----ITAMVYHRSSDLFALALDDLSIVVIDAVTQRVV 578 Query: 213 RVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPT 272 R L GH + + D+ PE I SAS D+ ++ WD +G CI I+ + +F P Sbjct: 579 RQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTGGCIDGII-VDNVATNVKFSP- 636 Query: 273 KGNLL 277 G+LL Sbjct: 637 NGDLL 641 Score = 30.0 bits (66), Expect = 2.4, Method: Compositional matrix adjust. Identities = 17/59 (28%), Positives = 29/59 (49%), Gaps = 3/59 (5%) Query: 319 MFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 +F LA D S+ D + + ++ + H IT+ ++P G +A+ D TIR W Sbjct: 557 LFALALDDLSIVVIDAV---TQRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTW 612 >5LCW-Q nrPDB Length = 374 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 68/328 (20%), Positives = 135/328 (41%), Gaps = 18/328 (5%) Query: 68 PNAYRGRDRVI-NLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFT 126 P + R R I +LP + + + + + W+ G L VA + + LW+ASS Sbjct: 33 PGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWS-SGNVLAVALDNSVY-LWSASSGD 90 Query: 127 FETLMQAHDSA--VTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMA 184 L+Q ++++ + + +++ G + +++W + K + + S R + Sbjct: 91 ILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLW--DVQQQKRLRNMTSHSARVGS 148 Query: 185 FSSNDSKFVTCSDDNILKIWNFSNGKQE-RVLSGHHWDVKSCDWHPEMGLIASASKDNLV 243 S N + S + + + LSGH +V W P+ +AS DNLV Sbjct: 149 LSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLV 208 Query: 244 KLW--DPRSGNCI--SSILKFKHTVLKTRFQPTKGNLLM--AISKDKSCRVFDIRYSMKE 297 +W P G + + + + V + P + N+L + D+ R++++ S Sbjct: 209 NVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV-CSGAC 267 Query: 298 LMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLS 357 L V + ++ W P + + + + + + + + H + SL+ Sbjct: 268 LSAVDAHSQVCSILWSPHYKELISGHGF--AQNQLVIWKYPTMAKVAELKGHTSRVLSLT 325 Query: 358 YNPVGHIFATAAKDRTIRFWTRARPIDP 385 +P G A+AA D T+R W R +DP Sbjct: 326 MSPDGATVASAAADETLRLW-RCFELDP 352 >5WBU-D nrPDB Length = 328 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 43/177 (24%), Positives = 73/177 (41%), Gaps = 16/177 (9%) Query: 91 KVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWM 150 +V I + P L+V SG +W+ + E L+ + ++T+ D+ +M Sbjct: 128 QVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYM 187 Query: 151 ISGDADGMIKIWQPNFSMVKEIDA--------AHTESIRDMAFSSNDSKFVTCSDDNILK 202 + ++ G +W + E+ AHT FS + + TCS D K Sbjct: 188 AAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCK 247 Query: 203 IW---NFSNGKQERVLSGHHWDVK-----SCDWHPEMGLIASASKDNLVKLWDPRSG 251 IW NFS + + SG+ + C + + I +AS DNL +LW +G Sbjct: 248 IWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETG 304 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 35/133 (26%), Positives = 56/133 (42%), Gaps = 16/133 (12%) Query: 103 PEGRRLVVATYSGEFSLWNASSFTFETLMQ--------AHDSAVTTMKYSHDSDWMISGD 154 P+ + +G +WN + + + Q AH ++S DS + + Sbjct: 182 PDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCS 241 Query: 155 ADGMIKIWQ-PNFSMVKEIDAAHT---ESIRD----MAFSSNDSKFVTCSDDNILKIWNF 206 AD KIW+ NFS++ E+ ES R AFS + VT S DN+ ++W Sbjct: 242 ADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCV 301 Query: 207 SNGKQERVLSGHH 219 G+ +R GH Sbjct: 302 ETGEIKREYGGHQ 314 Score = 37.7 bits (86), Expect = 0.010, Method: Compositional matrix adjust. Identities = 48/249 (19%), Positives = 99/249 (39%), Gaps = 28/249 (11%) Query: 70 AYRGRDRVINLPSKFTHLSSNKVKHV---IPAIQWTPEGRRLVVATYSGEFSLWNASSFT 126 A G D + + + + V+H + A++ TP+ R ++ A +++ +S Sbjct: 18 ATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPD-RSMIAAAGYQHIRMYDLNSNN 76 Query: 127 FETLMQAHDSA---VTTMKYSHDSDWMISGDADGMIKIW-----QPNFSMVKEIDAAHTE 178 ++ ++D + ++ + D WM +G D +IW + +++A Sbjct: 77 PNPII-SYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAP--- 132 Query: 179 SIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASAS 238 I + N ++ + + IW+ E+++ + S P+ +A+ + Sbjct: 133 -INCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVN 191 Query: 239 KDNLVKLWDPRSG---NCISSILKFK---HT--VLKTRFQPTKGNLLMAISKDKSCRVFD 290 +W+ G I K K HT L+ RF P LL S D++C+++ Sbjct: 192 STGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSADQTCKIW- 249 Query: 291 IRYSMKELM 299 R S LM Sbjct: 250 -RTSNFSLM 257 Score = 32.7 bits (73), Expect = 0.36, Method: Compositional matrix adjust. Identities = 37/231 (16%), Positives = 91/231 (39%), Gaps = 13/231 (5%) Query: 156 DGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVL 215 D ++ WQ + + H +S + + D + + +++++ ++ ++ Sbjct: 23 DHTVRFWQAHSGICTRT-VQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPII 81 Query: 216 S--GHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNC-ISSILKFKHTVLKTRFQPT 272 S G + ++ S +H + + + +D ++WD RS N I + + P Sbjct: 82 SYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPN 141 Query: 273 KGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHF 332 + L++ + + ++D++ E + E + P + S G+ + Sbjct: 142 QAELIVG-DQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP-DASYMAAVNSTGNCYVW 199 Query: 333 DLLQNLNE------PILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 +L + + P IP AH + ++P + AT + D+T + W Sbjct: 200 NLTGGIGDEVTQLIPKTKIP-AHTRYALQCRFSPDSTLLATCSADQTCKIW 249 Score = 32.3 bits (72), Expect = 0.43, Method: Compositional matrix adjust. Identities = 35/165 (21%), Positives = 67/165 (40%), Gaps = 33/165 (20%) Query: 53 LVVEPETSYTIDIMPPNAY-------RGRDRVINLPSKFTHLSSNKVKHVIP-------- 97 L+ EPE S T + P+A G V NL ++V +IP Sbjct: 167 LIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGI----GDEVTQLIPKTKIPAHT 222 Query: 98 --AIQ--WTPEGRRLVVATYSGEFSLWNASSFTFETLM--------QAHDSAVTTMKYSH 145 A+Q ++P+ L + +W S+F+ T + ++ + +S Sbjct: 223 RYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSG 282 Query: 146 DSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDS 190 DS ++++ +D + ++W +K H +++ +AF NDS Sbjct: 283 DSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF--NDS 325 >2YNP-A nrPDB Length = 604 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 66/325 (20%), Positives = 129/325 (39%), Gaps = 67/325 (20%) Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDA 155 + I + P ++ YSG LWN + +Q ++ V K+ +W+I G Sbjct: 16 VKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIARKNWIIVGSD 75 Query: 156 DGMIKIWQPNFSMVKEID-AAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNG-KQER 213 D I+++ N + K +D AH + IR +A ++ SDD +K+WN+ N E+ Sbjct: 76 DFRIRVFNYN-TGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALEQ 134 Query: 214 VLSGHHWDVKSCDWHP---------------------------------EMGL------- 233 GH V ++P E G+ Sbjct: 135 TFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYP 194 Query: 234 ------IASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCR 287 + +AS D +K+WD ++ +C++++ V F PT ++++ S+D + + Sbjct: 195 LPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTL-PIIISGSEDGTLK 253 Query: 288 VFDIR-YSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIP 346 +++ Y +++ + V E + + HP + + +D L +EP Sbjct: 254 IWNSSTYKVEKTLNVGLERSW-CIATHPTGRKNYIASGFDNGFTVLSLGN--DEP----- 305 Query: 347 YAHDKCITSLSYNPVGHIFATAAKD 371 +LS +PVG + + K+ Sbjct: 306 --------TLSLDPVGKLVWSGGKN 322 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 43/233 (18%), Positives = 102/233 (43%), Gaps = 8/233 (3%) Query: 149 WMISGDADGMIKIWQPNFSM-VKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFS 207 W+++ G +++W + V+ I T +R F + + + SDD ++++N++ Sbjct: 27 WVLTTLYSGRVELWNYETQVEVRSIQVTET-PVRAGKFIARKNWIIVGSDDFRIRVFNYN 85 Query: 208 NGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILK-FKHTVLK 266 G++ H ++S HP + S S D VKLW+ + + + +H V+ Sbjct: 86 TGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALEQTFEGHEHFVMC 145 Query: 267 TRFQPTKGNLLMAISKDKSCRVFDIRYSMKEL-MCVRDETDYMTLEWHPINESMFTL-AC 324 F P + + D++ +V+ + S + E ++++P+ + + + A Sbjct: 146 VAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITAS 205 Query: 325 YDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 D ++K +D + + H ++ ++P I + ++D T++ W Sbjct: 206 DDLTIKIWDY---QTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIW 255 Score = 32.7 bits (73), Expect = 0.31, Method: Compositional matrix adjust. Identities = 35/162 (21%), Positives = 72/162 (44%), Gaps = 7/162 (4%) Query: 222 VKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAIS 281 VK D+HP + + V+LW+ + + SI + V +F K N ++ S Sbjct: 16 VKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIARK-NWIIVGS 74 Query: 282 KDKSCRVFDIRYSMKELMCVRDETDYM-TLEWHPINESMFTLACYDGSLKHFDLLQNLNE 340 D RVF+ + ++++ DY+ ++ HP + + D ++K ++ N Sbjct: 75 DDFRIRVFNYN-TGEKVVDFEAHPDYIRSIAVHPTKPYVLS-GSDDLTVKLWNWENNW-- 130 Query: 341 PILTIPYAHDKCITSLSYNPVG-HIFATAAKDRTIRFWTRAR 381 + H+ + +++NP FA+ DRT++ W+ + Sbjct: 131 ALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQ 172 >3CFV-B nrPDB Length = 414 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 57/234 (24%), Positives = 98/234 (41%), Gaps = 25/234 (10%) Query: 175 AHTESIRDMAFSSNDS-KFVTCSDDNILKIWNFSNGKQE-------RVLSGHHWDVKSCD 226 H + ++++SN S ++ SDD+ + +W+ + G +E + +GH V+ Sbjct: 177 GHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVA 236 Query: 227 WH-PEMGLIASASKDNLVKLWDPRSGNCIS-SILKFKHT--VLKTRFQPTKGNLLMAISK 282 WH L S + D + +WD RS S L HT V F P +L S Sbjct: 237 WHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSA 296 Query: 283 DKSCRVFDIRYSMKELMCVRDETDYM-TLEWHPINESMFTLACYDGSLKHFDLLQNLNE- 340 DK+ ++D+R +L D + + W P NE++ + D L +DL + E Sbjct: 297 DKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQ 356 Query: 341 ----------PILTIPYAHDKCITSLSYNP-VGHIFATAAKDRTIRFWTRARPI 383 +L I H I+ S+NP + + ++D ++ W A I Sbjct: 357 SAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENI 410 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 42/167 (25%), Positives = 62/167 (37%), Gaps = 42/167 (25%) Query: 215 LSGHHWDVKSCDWHPEM-GLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTK 273 L GH + W+ + G + SAS D+ V LWD +G P + Sbjct: 175 LRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAG-------------------PKE 215 Query: 274 GNLL--MAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKH 331 G ++ AI S V D+ WH ++ES+F D L Sbjct: 216 GKIVDAKAIFTGHSAVVEDVA-------------------WHLLHESLFGSVADDQKLMI 256 Query: 332 FDLLQNLNEPILTIPYAHDKCITSLSYNPVGH-IFATAAKDRTIRFW 377 +D N + AH + LS+NP I AT + D+T+ W Sbjct: 257 WDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 303 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 42/208 (20%), Positives = 90/208 (43%), Gaps = 27/208 (12%) Query: 61 YTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGE-FSL 119 +T+ + NA ++++ + FT S+ V+ + W L + + + Sbjct: 202 HTVCLWDINAGPKEGKIVDAKAIFTGHSA-----VVEDVAWHLLHESLFGSVADDQKLMI 256 Query: 120 WNASSFTFET---LMQAHDSAVTTMKYSHDSDWMIS-GDADGMIKIWQ-PNFSMVKEIDA 174 W+ S T L+ AH + V + ++ S+++++ G AD + +W N + Sbjct: 257 WDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFE 316 Query: 175 AHTESIRDMAFS-SNDSKFVTCSDDNILKIWNFSNGKQER--------------VLSGHH 219 +H + I + +S N++ + D L +W+ S +E+ + GH Sbjct: 317 SHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHT 376 Query: 220 WDVKSCDWHP-EMGLIASASKDNLVKLW 246 + W+P E +I S S+DN++++W Sbjct: 377 AKISDFSWNPNEPWVICSVSEDNIMQIW 404 >4J0W-A nrPDB Length = 343 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 28/114 (24%), Positives = 47/114 (41%) Query: 133 AHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKF 192 H S V M S D ++ SGD +I IW+ H +++ +AF + Sbjct: 65 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 124 Query: 193 VTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW 246 + S D +K+WN + L GH V + D + + +D V++W Sbjct: 125 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVW 178 Score = 34.3 bits (77), Expect = 0.11, Method: Compositional matrix adjust. Identities = 21/91 (23%), Positives = 40/91 (43%), Gaps = 4/91 (4%) Query: 119 LWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ-PNFSMVKEIDAAHT 177 +WN + ++ + H AV + + +G DG +++W+ P S + + H Sbjct: 135 VWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL--VFYGHQ 192 Query: 178 ESIRDMAFSSNDSKFVTCSDDNILKIWNFSN 208 SI D N+ V+ +DD + +W S Sbjct: 193 GSI-DCIHLINEEHMVSGADDGSVALWGLSK 222 Score = 30.0 bits (66), Expect = 2.2, Method: Compositional matrix adjust. Identities = 44/216 (20%), Positives = 79/216 (36%), Gaps = 22/216 (10%) Query: 175 AHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLI 234 H+ + MA SS+ + ++ IW + + +GH V + + Sbjct: 65 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 124 Query: 235 ASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDI-RY 293 S S D VK+W+ + + ++ + V ++ + A +D + RV+ I Sbjct: 125 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALD-ALSRECCVTAGGRDGTVRVWKIPEE 183 Query: 294 SMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDL-------LQN-----LNEP 341 S + D + H INE DGS+ + L LQ EP Sbjct: 184 SQLVFYGHQGSIDCI----HLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEP 239 Query: 342 ILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 L P+ I+S++ + AT + +R W Sbjct: 240 GLEQPFW----ISSVAALLNTDLVATGSHSSCVRLW 271 >6EMK-B nrPDB Length = 303 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 54/234 (23%), Positives = 96/234 (41%), Gaps = 27/234 (11%) Query: 1 MDGHNQN------QYQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLV 54 +GH N Q N+ + S+ +K + DV SP I Y + +V Sbjct: 71 FEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW-------DVRSPSIPRNYKHNAPVNEVV 123 Query: 55 VEPETSYTIDIMPPNAYRGRDRVINL-PSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATY 113 + P I G R+ +L ++ TH + + + ++ +G L A Sbjct: 124 IHPNQGELISC----DRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANT 179 Query: 114 SGEFSLW------NASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ--PN 165 G +W +AS T +AH + +T + S D + + AD ++W + Sbjct: 180 KGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDD 239 Query: 166 FSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHH 219 F + +D H + D AFS++ + VT S D+ +++W+ S + R GHH Sbjct: 240 FKLETTLDG-HQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHH 292 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 53/279 (18%), Positives = 109/279 (39%), Gaps = 15/279 (5%) Query: 108 LVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGM----IKIWQ 163 LV A Y W A + +Q DS V ++ ++D + + + I+ Sbjct: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTN 64 Query: 164 PNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVK 223 PN E H ++ ++F ++ VT S+D +K+W+ + R H+ V Sbjct: 65 PNPVASFE---GHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVN 120 Query: 224 SCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKD 283 HP G + S +D +++WD C + T L++ + G++L A + Sbjct: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 Query: 284 KSCRVFDI-----RYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNL 338 +C V+++ +K + R + Y+T + D + + + + + Sbjct: 181 GNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDF 240 Query: 339 NEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 + T H + + +++ TA+ D +R W Sbjct: 241 --KLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 35/153 (22%), Positives = 66/153 (43%), Gaps = 8/153 (5%) Query: 103 PEGRRLVVATYSGEFSLWN-ASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKI 161 P L+ G +W+ + L D+++ ++ + D + + + G + Sbjct: 126 PNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYV 185 Query: 162 WQ-PNFSMVKEID-----AAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNG-KQERV 214 W+ PN + + AH+ I + SS+ TCS D+ ++W+ + K E Sbjct: 186 WEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETT 245 Query: 215 LSGHHWDVKSCDWHPEMGLIASASKDNLVKLWD 247 L GH V C + + + +AS D+ V+LWD Sbjct: 246 LDGHQRWVWDCAFSADSAYLVTASSDHYVRLWD 278 Score = 36.2 bits (82), Expect = 0.031, Method: Compositional matrix adjust. Identities = 31/147 (21%), Positives = 65/147 (44%), Gaps = 9/147 (6%) Query: 233 LIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIR 292 ++ SA D+ ++ W+ +G C +I V R + T L+A + ++ R++DIR Sbjct: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQV--NRLEITNDKKLLATAGHQNVRLYDIR 61 Query: 293 YSMKELMCVRD--ETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHD 350 + + + + ++ + N M T + DG++K +D + P + Y H+ Sbjct: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVT-SSEDGTIKVWD----VRSPSIPRNYKHN 116 Query: 351 KCITSLSYNPVGHIFATAAKDRTIRFW 377 + + +P + +D IR W Sbjct: 117 APVNEVVIHPNQGELISCDRDGNIRIW 143 >5FVM-C nrPDB Length = 303 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 51/277 (18%), Positives = 112/277 (40%), Gaps = 11/277 (3%) Query: 108 LVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDA--DGMIKIWQPN 165 L A Y W A + +Q DS V ++ + D ++ + + I N Sbjct: 5 LASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGHLHVRLYDIRSNN 64 Query: 166 FSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSC 225 + V + H ++ +AF + V+ S+D +K+W+ + +R H+ V Sbjct: 65 PNPVSSFEG-HKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYK-HNAPVNEV 122 Query: 226 DWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKS 285 HP G + S +D +++WD C + + +T L++ + G++L+A + + Sbjct: 123 AIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNKGN 182 Query: 286 CRVFDIRY-----SMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNE 340 C V+ + + +++ + + T Y+T + D + + +++ N Sbjct: 183 CYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNIEDNYQ- 241 Query: 341 PILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 + T H + + +++ TA D +R W Sbjct: 242 -LETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLW 277 Score = 51.6 bits (122), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 33/153 (21%), Positives = 67/153 (43%), Gaps = 8/153 (5%) Query: 103 PEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSA-VTTMKYSHDSDWMISGDADGMIKI 161 P L+ G +W+ + D+ + ++ + D +++G+ G + Sbjct: 126 PNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNKGNCYV 185 Query: 162 WQ-PNFSMVKEID-----AAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQ-ERV 214 W+ P+ + ++ +HT+ I + S++ TCS D+ ++WN + Q E Sbjct: 186 WRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNIEDNYQLETT 245 Query: 215 LSGHHWDVKSCDWHPEMGLIASASKDNLVKLWD 247 L GH V C + + + +A D+ V+LWD Sbjct: 246 LDGHQRWVWDCAFSADSAYLVTACSDHYVRLWD 278 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 53/239 (22%), Positives = 92/239 (38%), Gaps = 37/239 (15%) Query: 1 MDGHNQN------QYQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLV 54 +GH N Q +N+ + S+ +K + DV SP + Y + + Sbjct: 71 FEGHKGNVTSIAFQQENRWMVSSSEDGTIKVW-------DVRSPSVQRNYKHNAPVNEVA 123 Query: 55 VEPETSYTIDIMPPNAYR----GRDRVIN--LPSKFTHLSSNKVKHVIPAIQWTPEGRRL 108 + P I R G ++ N P T L S V +G L Sbjct: 124 IHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSV---------ASDGSML 174 Query: 109 VVATYSGEFSLW------NASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIW 162 V G +W +AS+ T ++H +T + S D + + AD ++W Sbjct: 175 VAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVW 234 Query: 163 --QPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHH 219 + N+ + +D H + D AFS++ + VT D+ +++W+ S + R GHH Sbjct: 235 NIEDNYQLETTLDG-HQRWVWDCAFSADSAYLVTACSDHYVRLWDLSTSEIVRQYGGHH 292 Score = 33.9 bits (76), Expect = 0.16, Method: Compositional matrix adjust. Identities = 30/147 (20%), Positives = 65/147 (44%), Gaps = 9/147 (6%) Query: 233 LIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIR 292 ++ASA D+ ++ W+ +G C +I V R + T +A + R++DIR Sbjct: 4 ILASAGYDHTIRFWEALTGVCSRTIQHADSQV--NRLEITSDKKYLAAAGHLHVRLYDIR 61 Query: 293 YSMKELMCVRD--ETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHD 350 + + + + + ++ + N M + + DG++K +D + P + Y H+ Sbjct: 62 SNNPNPVSSFEGHKGNVTSIAFQQENRWMVS-SSEDGTIKVWD----VRSPSVQRNYKHN 116 Query: 351 KCITSLSYNPVGHIFATAAKDRTIRFW 377 + ++ +P + +D IR W Sbjct: 117 APVNEVAIHPNQGELISCDQDGNIRIW 143 >3MKQ-A nrPDB Length = 814 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 41/154 (26%), Positives = 70/154 (45%), Gaps = 4/154 (2%) Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDA 155 + I + P ++ YSG +WN + +Q ++ V K+ +W+I G Sbjct: 16 VKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKFIARKNWIIVGSD 75 Query: 156 DGMIKIWQPNFSMVKEID-AAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNG-KQER 213 D I+++ N + K +D AH + IR +A ++ SDD +K+WN+ N E+ Sbjct: 76 DFRIRVFNYN-TGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALEQ 134 Query: 214 VLSGHHWDVKSCDWHP-EMGLIASASKDNLVKLW 246 GH V ++P + AS D VK+W Sbjct: 135 TFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVW 168 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 35/143 (24%), Positives = 65/143 (45%), Gaps = 17/143 (11%) Query: 119 LWN-ASSFTFETLMQAHDSAVTTMKYS-HDSDWMISGDADGMIKIWQ-----PNFSMV-- 169 LWN +++ E + H+ V + ++ D SG D +K+W PNF++ Sbjct: 123 LWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTG 182 Query: 170 --KEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDW 227 + ++ + D + +T SDD +KIW++ L GH +V + Sbjct: 183 QERGVNYVDYYPLPDKPY------MITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVF 236 Query: 228 HPEMGLIASASKDNLVKLWDPRS 250 HP + +I S S+D +K+W+ + Sbjct: 237 HPTLPIIISGSEDGTLKIWNSST 259 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 44/233 (18%), Positives = 102/233 (43%), Gaps = 8/233 (3%) Query: 149 WMISGDADGMIKIWQPNFSM-VKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFS 207 W+++ G ++IW + V+ I T +R F + + + SDD ++++N++ Sbjct: 27 WVLTTLYSGRVEIWNYETQVEVRSIQVTET-PVRAGKFIARKNWIIVGSDDFRIRVFNYN 85 Query: 208 NGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILK-FKHTVLK 266 G++ H ++S HP + S S D VKLW+ + + + +H V+ Sbjct: 86 TGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALEQTFEGHEHFVMC 145 Query: 267 TRFQPTKGNLLMAISKDKSCRVFDIRYSMKEL-MCVRDETDYMTLEWHPINESMFTL-AC 324 F P + + D++ +V+ + S + E ++++P+ + + + A Sbjct: 146 VAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITAS 205 Query: 325 YDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 D ++K +D + + H ++ ++P I + ++D T++ W Sbjct: 206 DDLTIKIWDY---QTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIW 255 Score = 34.3 bits (77), Expect = 0.12, Method: Compositional matrix adjust. Identities = 25/90 (27%), Positives = 36/90 (40%), Gaps = 2/90 (2%) Query: 129 TLMQAHDSAVTTMKYSH--DSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFS 186 TL + V + Y D +MI+ D IKIW H ++ F Sbjct: 178 TLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFH 237 Query: 187 SNDSKFVTCSDDNILKIWNFSNGKQERVLS 216 ++ S+D LKIWN S K E+ L+ Sbjct: 238 PTLPIIISGSEDGTLKIWNSSTYKVEKTLN 267 Score = 31.2 bits (69), Expect = 0.93, Method: Compositional matrix adjust. Identities = 35/162 (21%), Positives = 70/162 (43%), Gaps = 7/162 (4%) Query: 222 VKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAIS 281 VK D+HP + + V++W+ + + SI + V +F K N ++ S Sbjct: 16 VKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKFIARK-NWIIVGS 74 Query: 282 KDKSCRVFDIRYSMKELMCVRDETDYM-TLEWHPINESMFTLACYDGSLKHFDLLQNLNE 340 D RVF+ K ++ DY+ ++ HP + + D ++K ++ N Sbjct: 75 DDFRIRVFNYNTGEK-VVDFEAHPDYIRSIAVHPTKPYVLS-GSDDLTVKLWNWENNW-- 130 Query: 341 PILTIPYAHDKCITSLSYNPVG-HIFATAAKDRTIRFWTRAR 381 + H+ + +++NP FA+ DRT++ W+ + Sbjct: 131 ALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQ 172 >5XYI-g nrPDB Length = 335 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 49/252 (19%), Positives = 99/252 (39%), Gaps = 52/252 (20%) Query: 133 AHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEID-----AAHTESIRDMAFSS 187 H++A+ +++ ++ ++++S D +W+ N + + H + D++ S Sbjct: 31 GHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVSLSR 90 Query: 188 NDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWD 247 + S +T S D+ L++W+ S +++ GH DV + P I S +DN VK+W Sbjct: 91 DASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIISVGRDNQVKIW- 149 Query: 248 PRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMC--VRDET 305 N+L + C + + + C + DET Sbjct: 150 ---------------------------NILGENKAELQCSSW-----VTSVACAPMADET 177 Query: 306 DYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIF 365 + + + C+DG + + + + ++ AHD TS+ + P G Sbjct: 178 SPLVI----------AVGCWDGKVYIWSIEKEAK--LIKEFKAHDGRCTSVDFTPDGKWV 225 Query: 366 ATAAKDRTIRFW 377 T DR + W Sbjct: 226 ITGGSDRKVVMW 237 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 13/56 (23%), Positives = 28/56 (50%), Gaps = 1/56 (1%) Query: 108 LVVATYSGEFSLWN-ASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIW 162 + V + G+ +W+ +AHD T++ ++ D W+I+G +D + +W Sbjct: 182 IAVGCWDGKVYIWSIEKEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMW 237 >5OQL-J nrPDB Length = 912 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 32/175 (18%), Positives = 75/175 (42%), Gaps = 25/175 (14%) Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYS----------- 144 I A+ +P G+ A+ +W+ + +++ H V T++++ Sbjct: 547 INALDISPNGKLFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQ 606 Query: 145 ---HDSDWMISGDADGMIKIWQ-PNFSMVKEIDAAHTESI---------RDMAFSSNDSK 191 +++G D IK+W +++ ++ + H+ ++ RD + + + Sbjct: 607 GSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEG-HSHNVLKVVWLHISRDDSITKTKVQ 665 Query: 192 FVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW 246 F + D ++K+W+ + G+ E L H + + H + ++ASA D+ V W Sbjct: 666 FASAGADTLVKVWDANTGETECTLDNHEDRLWTLAVHSKTNILASAGSDSKVTFW 720 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 49/217 (22%), Positives = 79/217 (36%), Gaps = 52/217 (23%) Query: 175 AHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHP----- 229 AH + I + S N F + S D +KIW+ + + +L GH V + + P Sbjct: 542 AHDKDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTPV 601 Query: 230 ---------EMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAI 280 G++ + S D +KLW+ CI + H VLK + + I Sbjct: 602 IQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKV--------VWLHI 653 Query: 281 SKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNE 340 S+D S ++ F A D +K +D N E Sbjct: 654 SRDDSITKTKVQ---------------------------FASAGADTLVKVWD--ANTGE 684 Query: 341 PILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 T+ D+ T L+ + +I A+A D + FW Sbjct: 685 TECTLDNHEDRLWT-LAVHSKTNILASAGSDSKVTFW 720 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 36/144 (25%), Positives = 51/144 (35%), Gaps = 23/144 (15%) Query: 133 AHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFS------ 186 AHD + + S + S D +KIW V+ I H + + F+ Sbjct: 542 AHDKDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTPV 601 Query: 187 --------SNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDW---------HP 229 S +T S D +K+WN S+ R GH +V W Sbjct: 602 IQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHISRDDSITK 661 Query: 230 EMGLIASASKDNLVKLWDPRSGNC 253 ASA D LVK+WD +G Sbjct: 662 TKVQFASAGADTLVKVWDANTGET 685 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 59/270 (21%), Positives = 98/270 (36%), Gaps = 42/270 (15%) Query: 132 QAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSK 191 +AH+S V + YS + ++SG D + +W + + E + + F + Sbjct: 229 EAHESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDGIWQGTPMLRHELLESVGFLNEGKW 288 Query: 192 FVTCSDDNILKIWNFSN-----GKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW 246 + +L+IW+ + KQ+ G + S PE LI A D + L+ Sbjct: 289 MYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEA--ILSAVSLPERSLILCAQADFTLVLY 346 Query: 247 D-PRSGNCISSILKFKHTVLKTRFQPTKGNL-----LMAISKDKSCRVFDIRYSMKELMC 300 P + +SS +L F+ G L I D+S ++ Sbjct: 347 RVPSPADVVSS----SEGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVS 402 Query: 301 VRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNP 360 V+D Y S C GS D+ + H+ + SL + Sbjct: 403 VKDAQAY----------SEDNAECRSGSYFGHDV---------ALLKGHEDIVMSLDVDW 443 Query: 361 VGHIFATAAKDRTIRFWTRARPIDP--NAY 388 GH A+ +KD T R W +DP N+Y Sbjct: 444 SGHWIASGSKDNTARLWR----VDPANNSY 469 Score = 37.4 bits (85), Expect = 0.013, Method: Compositional matrix adjust. Identities = 19/66 (28%), Positives = 33/66 (50%), Gaps = 6/66 (9%) Query: 318 SMFTLA--CYDGSLKHFDLLQNLNEPILTIPY----AHDKCITSLSYNPVGHIFATAAKD 371 S F LA DG ++ FDL + P+ P AH+ + ++Y+P H + ++D Sbjct: 194 SRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRD 253 Query: 372 RTIRFW 377 +T+ W Sbjct: 254 KTMTLW 259 Score = 29.3 bits (64), Expect = 3.7, Method: Compositional matrix adjust. Identities = 19/75 (25%), Positives = 31/75 (41%), Gaps = 8/75 (10%) Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNAS--------SFTFETLMQAHDSAVTTMKYSHDS 147 I + TP G L+V + S +++ + T + H + V + S Sbjct: 64 ISTLTITPSGSHLIVCSRSLTMRIYSLAISPDYDSVEPTLVRTTKPHATPVVVLAVDRTS 123 Query: 148 DWMISGDADGMIKIW 162 + +G ADG IKIW Sbjct: 124 TLLATGAADGAIKIW 138 >4N14-A nrPDB Length = 314 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 64/316 (20%), Positives = 130/316 (41%), Gaps = 17/316 (5%) Query: 79 NLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSA- 137 +LP + + + + + W+ G L VA + + LW+ASS L+Q Sbjct: 7 SLPDRILDAPEIRNDYYLNLVDWS-SGNVLAVALDNSVY-LWSASSGDILQLLQMEQPGE 64 Query: 138 -VTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCS 196 ++++ + + +++ G + +++W + K + + S R + S N + S Sbjct: 65 YISSVAWIKEGNYLAVGTSSAEVQLW--DVQQQKRLRNMTSHSARVGSLSWNSYILSSGS 122 Query: 197 DDNILKIWNFSNGKQE-RVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW--DPRSGNC 253 + + + LSGH +V W P+ +AS DNLV +W P G Sbjct: 123 RSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGW 182 Query: 254 I--SSILKFKHTVLKTRFQPTKGNLLM--AISKDKSCRVFDIRYSMKELMCVRDETDYMT 309 + + + + V + P + N+L + D+ R++++ S L V + + Sbjct: 183 VPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV-CSGACLSAVDAHSQVCS 241 Query: 310 LEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAA 369 + W P + + + + + + + + H + SL+ +P G A+AA Sbjct: 242 ILWSPHYKELISGHGF--AQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAA 299 Query: 370 KDRTIRFWTRARPIDP 385 D T+R W R +DP Sbjct: 300 ADETLRLW-RCFELDP 314 >5WLC-LJ nrPDB Length = 513 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 53/221 (23%), Positives = 103/221 (46%), Gaps = 32/221 (14%) Query: 137 AVTTMKYSHDSDWMISGDADGMIKIWQPN--FSMVKEIDAAHTESIRDMAFSSNDSKFV- 193 V + + D + +GDA G++ ++ +++ I+A+ T F + D+K + Sbjct: 83 VVYSASFRSDGKLLCAGDATGLVSVYDSYNPRTILLSINAS-THPTHVTKFHTQDNKILA 141 Query: 194 TCSDDNILKIWNFSNGKQERV-LSGHHWDVKSCDWHPEM-GLIASASKDNLVKLWDPRSG 251 T SDD + ++W+ SN + ++ L+G V++ + P L+A+ S D L++L+D RS Sbjct: 142 TASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTRSS 201 Query: 252 NCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSC-----RVFDIRYSM---------KE 297 + I H QP + + ++ ++ SC +V+D+ + K Sbjct: 202 GS-TPIYSLNHD------QPVENVIAVSPTQIVSCGGNNFKVWDLTSNKKLYERGNFNKA 254 Query: 298 LMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNL 338 + C+ DY+ P+ +S + DG +K FD L N Sbjct: 255 VTCL----DYVENFDSPM-QSALIASSLDGHVKVFDPLDNF 290 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 31/128 (24%), Positives = 58/128 (45%), Gaps = 6/128 (4%) Query: 222 VKSCDWHPEMGLIASASKDNLVKLWD---PRSGNCISSILKFKHTVLKTRFQPTKGNLLM 278 V S + + L+ + LV ++D PR+ + SI H T+F +L Sbjct: 84 VYSASFRSDGKLLCAGDATGLVSVYDSYNPRT--ILLSINASTHPTHVTKFHTQDNKILA 141 Query: 279 AISKDKSCRVFDIRYSMKELMCVRDETDYM-TLEWHPINESMFTLACYDGSLKHFDLLQN 337 S D+ R++DI + + + + TDY+ TL + P + YDG ++ +D + Sbjct: 142 TASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTRSS 201 Query: 338 LNEPILTI 345 + PI ++ Sbjct: 202 GSTPIYSL 209 Score = 33.5 bits (75), Expect = 0.21, Method: Compositional matrix adjust. Identities = 31/153 (20%), Positives = 63/153 (41%), Gaps = 6/153 (3%) Query: 150 MISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNG 209 + +G DG+I+++ S I + + + + + + ++ V+C +N K+W+ ++ Sbjct: 184 VATGSYDGLIRLYDTRSSGSTPIYSLNHDQPVENVIAVSPTQIVSCGGNN-FKVWDLTSN 242 Query: 210 KQERVLSGHHWDVKSCDW-----HPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTV 264 K+ + V D+ P + ++S D VK++DP + KF V Sbjct: 243 KKLYERGNFNKAVTCLDYVENFDSPMQSALIASSLDGHVKVFDPLDNFQVKFGWKFSGPV 302 Query: 265 LKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKE 297 L P+ + S + IR KE Sbjct: 303 LSCAVSPSTAQGNRHLVAGLSSGLLAIRTKKKE 335 >5OV3-A nrPDB Length = 381 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 46/192 (23%), Positives = 82/192 (42%), Gaps = 14/192 (7%) Query: 193 VTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGN 252 V C+D I+ IW+F +++S H V S W + + SAS DN+V WD SG+ Sbjct: 42 VGCNDGRIV-IWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGD 100 Query: 253 CISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDY-MTLE 311 C +F +LK ++ P N ++ + + + S ++ V D++D + Sbjct: 101 C-DQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVAS 159 Query: 312 WHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPY------AHDKCITSLSYNPVGHIF 365 + E ++T G+ K L+ + L + ++ I S+ + G F Sbjct: 160 FDRRGEYIYT-----GNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCF 214 Query: 366 ATAAKDRTIRFW 377 DR IR + Sbjct: 215 LINTADRIIRVY 226 Score = 34.3 bits (77), Expect = 0.12, Method: Compositional matrix adjust. Identities = 20/74 (27%), Positives = 34/74 (45%) Query: 136 SAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTC 195 S T ++ + G DG I IW + +I +AH + + +S + K V+ Sbjct: 26 SMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSA 85 Query: 196 SDDNILKIWNFSNG 209 S DNI+ W+ +G Sbjct: 86 STDNIVSQWDVLSG 99 Score = 29.6 bits (65), Expect = 3.2, Method: Compositional matrix adjust. Identities = 13/58 (22%), Positives = 25/58 (43%) Query: 105 GRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIW 162 G L V G +W+ + ++ AH V ++ +S D ++S D ++ W Sbjct: 37 GTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQW 94 >5N4A-A nrPDB Length = 771 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 41/185 (22%), Positives = 78/185 (42%), Gaps = 5/185 (2%) Query: 128 ETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSS 187 E ++ H A ++++S+D + + DG +KIW N M++ A + + ++ Sbjct: 97 EKSIEGHKGACISLRWSYDGTALATAGEDGSVKIWSRN-GMLRSTLAQADSPVYSIVWAY 155 Query: 188 NDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWD 247 + + C+ N++ I + S+ ++ H V DW P LI + +D K+WD Sbjct: 156 DCDQLCYCTGSNVV-IKSLSSNAKQNAWKAHDGVVLKVDWSPINHLIITGGEDCKYKVWD 214 Query: 248 PRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDY 307 S L F + V + P+ L A+ + ++ D + + D Sbjct: 215 SFGRLLFQSGL-FDYPVTSVAWAPS--GELFAVGGFNTLQLCDRMGWAYSKIHLNDTGSI 271 Query: 308 MTLEW 312 MTL W Sbjct: 272 MTLSW 276 Score = 37.4 bits (85), Expect = 0.013, Method: Compositional matrix adjust. Identities = 20/81 (24%), Positives = 37/81 (45%), Gaps = 12/81 (14%) Query: 307 YMTLEWHPINES--------MFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSY 358 + + W+P++ +F +AC DGS+K + + I H SL + Sbjct: 57 FTDMHWYPVSSKKTQAGGTDVFAVACTDGSVKILSRTGRVEKSI----EGHKGACISLRW 112 Query: 359 NPVGHIFATAAKDRTIRFWTR 379 + G ATA +D +++ W+R Sbjct: 113 SYDGTALATAGEDGSVKIWSR 133 Score = 36.2 bits (82), Expect = 0.034, Method: Compositional matrix adjust. Identities = 41/198 (20%), Positives = 78/198 (39%), Gaps = 22/198 (11%) Query: 191 KFVTCSDDNILKIWNFSNGKQERV--LSGHHWDVKSCDWHP------EMG---LIASASK 239 + TCSDD + WN +++V L + D+ W+P + G + A A Sbjct: 27 ELFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMH---WYPVSSKKTQAGGTDVFAVACT 83 Query: 240 DNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELM 299 D VK+ R+G SI K + R+ G L +D S +++ ++ + Sbjct: 84 DGSVKIL-SRTGRVEKSIEGHKGACISLRW-SYDGTALATAGEDGSVKIWSRNGMLRSTL 141 Query: 300 CVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYN 359 D Y + + ++ + C ++ L N + AHD + + ++ Sbjct: 142 AQADSPVYSIVWAYDCDQLCY---CTGSNVVIKSLSSNAKQNAWK---AHDGVVLKVDWS 195 Query: 360 PVGHIFATAAKDRTIRFW 377 P+ H+ T +D + W Sbjct: 196 PINHLIITGGEDCKYKVW 213 Score = 35.8 bits (81), Expect = 0.039, Method: Compositional matrix adjust. Identities = 43/184 (23%), Positives = 76/184 (41%), Gaps = 24/184 (13%) Query: 193 VTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGN 252 V C+D ++ KI + G+ E+ + GH S W + +A+A +D VK+W R+G Sbjct: 80 VACTDGSV-KILS-RTGRVEKSIEGHKGACISLRWSYDGTALATAGEDGSVKIW-SRNGM 136 Query: 253 CISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDY----- 307 S++ + V +++ A D+ C +K L + + Sbjct: 137 LRSTLAQADSPVY---------SIVWAYDCDQLCYCTGSNVVIKSLSSNAKQNAWKAHDG 187 Query: 308 --MTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIF 365 + ++W PIN + T D K +D L L D +TS+++ P G +F Sbjct: 188 VVLKVDWSPINHLIIT-GGEDCKYKVWDSFGRL----LFQSGLFDYPVTSVAWAPSGELF 242 Query: 366 ATAA 369 A Sbjct: 243 AVGG 246 >5OQL-X nrPDB Length = 630 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 27/117 (23%), Positives = 55/117 (47%), Gaps = 4/117 (3%) Query: 132 QAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDA--AHTESIRDMAFSSND 189 Q H A +K S D ++++G AD + ++ N + +K I A H +++ +AF Sbjct: 243 QGHLKAPLVVKASQDGKFVVTGGADKRLVVY--NAADLKPIKAFTQHRDAVTGLAFRRGT 300 Query: 190 SKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW 246 ++ +CS D +K+W+ L GH ++ D + ++ ++D + W Sbjct: 301 NQLYSCSKDRTVKVWSLDELAYVETLFGHQDEILDIDALGQERCVSVGARDRTARYW 357 >3JB9-L nrPDB Length = 340 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 39/162 (24%), Positives = 77/162 (47%), Gaps = 11/162 (6%) Query: 93 KHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMIS 152 K+ + A+ +G ++ + G +W+ + +++ H +T++ S D ++S Sbjct: 177 KYPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCSHVLKGHKDIITSLAISKDGSSLLS 236 Query: 153 GDADGMIKIW--QPNFSMVKEID----AAHTE--SIRDMAFSSNDSKFVTC-SDDNILKI 203 D ++I+ +P S +++ A H + ++ +A+S N S+FV S D + + Sbjct: 237 NSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRN-SRFVGAGSSDKNVYV 295 Query: 204 WNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKL 245 W+ + G VL GH V D+HP +I S S D + L Sbjct: 296 WS-ATGDLRYVLPGHEGSVNHVDFHPHQDIILSCSSDRTIFL 336 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 51/215 (23%), Positives = 85/215 (39%), Gaps = 11/215 (5%) Query: 164 PNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWN-FSNGKQERVLSGHHWDV 222 PN M HT + F + S F + D + +WN F + K VL+G + Sbjct: 42 PNLQMF-----GHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAI 96 Query: 223 KSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISK 282 W + ++ +S D + WD SG I V LL ++S Sbjct: 97 TDLQWSRDSRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSD 156 Query: 283 DKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPI 342 D + +V+D R K+ + +E +T + + DG++K +DL N + Sbjct: 157 DCTMKVWDSRS--KDCIKTIEEKYPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCSHV 214 Query: 343 LTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 L H ITSL+ + G + + D T+R + Sbjct: 215 LK---GHKDIITSLAISKDGSSLLSNSMDNTVRIF 246 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 49/210 (23%), Positives = 82/210 (39%), Gaps = 54/210 (25%) Query: 131 MQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ-----PNFSMVKEIDAAHTESIRDMAF 185 M H + V ++ + SG D I +W N+ ++ A I D+ + Sbjct: 46 MFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGA----ITDLQW 101 Query: 186 SSNDSKFVTCSD-DNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMG--LIASASKDNL 242 S DS+ V CS D L W+ +G++ R GH V + D ++G L+ S S D Sbjct: 102 S-RDSRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDV-LKVGSELLTSVSDDCT 159 Query: 243 VKLWDPRSGNCI----------------------------------------SSILKFKH 262 +K+WD RS +CI S +LK Sbjct: 160 MKVWDSRSKDCIKTIEEKYPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCSHVLKGHK 219 Query: 263 TVLKTRFQPTKGNLLMAISKDKSCRVFDIR 292 ++ + G+ L++ S D + R+FD++ Sbjct: 220 DIITSLAISKDGSSLLSNSMDNTVRIFDVK 249 Score = 37.7 bits (86), Expect = 0.011, Method: Compositional matrix adjust. Identities = 31/156 (19%), Positives = 69/156 (44%), Gaps = 10/156 (6%) Query: 138 VTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSD 197 +T + + + G DG IKIW + + H + I +A S + S ++ S Sbjct: 180 LTAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCSHVLKGHKDIITSLAISKDGSSLLSNSM 239 Query: 198 DNILKIWN---FSNGKQ-----ERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPR 249 DN ++I++ F++ ++ E + G ++ W + + S D V +W Sbjct: 240 DNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVWSA- 298 Query: 250 SGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKS 285 +G+ + + +V F P + +++++ S D++ Sbjct: 299 TGDLRYVLPGHEGSVNHVDFHPHQ-DIILSCSSDRT 333 >3F3P-A nrPDB Length = 351 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 64/261 (24%), Positives = 106/261 (40%), Gaps = 40/261 (15%) Query: 172 IDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNF----SNGKQERVLSGHHWDVKSCDW 227 D+ H + + D+ + TCS D +K++ SN + H + + DW Sbjct: 6 FDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDW 65 Query: 228 -HPEMG-LIASASKDNLVKLW--DPRSGNC-------ISSILKFKHTVLKTRFQPTKGNL 276 PE G +IASAS D VKLW DP C + ++ K ++ +F P L Sbjct: 66 ASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGL 125 Query: 277 LMA-ISKDKSCRVFDI-------RYSMKELMCVRD-------ETDYMTLEWHPINESMFT 321 +A + D R++D +++ M V ++D+ L W P S Sbjct: 126 KLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDF-CLSWCPSRFSPEK 184 Query: 322 LACYDGSLKHFDLLQNLNEPILTIPY---AHDKCITSLSYNP-VG---HIFATAAKDRTI 374 LA +L+ + Q + L + H I S+S+ P +G + AT KD I Sbjct: 185 LAV--SALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRI 242 Query: 375 RFWTRARPIDPNAYDDPTYNN 395 R + + P A ++ N+ Sbjct: 243 RIFKITEKLSPLASEESLTNS 263 Score = 30.0 bits (66), Expect = 2.4, Method: Compositional matrix adjust. Identities = 14/45 (31%), Positives = 24/45 (53%) Query: 333 DLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 +L NL +L+ H+ + S+S+N G I ++A D +R W Sbjct: 289 ELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLW 333 >4L9O-A nrPDB Length = 349 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 55/233 (23%), Positives = 97/233 (41%), Gaps = 33/233 (14%) Query: 172 IDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERV--LSGHHWDVKSCDW-H 228 I AH + I D + TCS D +KI+ Q V L GH V W H Sbjct: 64 IGNAHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAH 123 Query: 229 PEMGLI-ASASKDNLVKLWDPRSG--NCISSILKFKHTVLKTRFQPTK-GNLLMAISKDK 284 P+ G+I AS S D V +W +G N ++ + +V + P + G +L+ S D Sbjct: 124 PKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDG 183 Query: 285 SCRVFDIR--YSMKELMCVRDETDYMTLEWHPIN-------------ESMFTLACYDGSL 329 + + + +++ ++ W PI+ +++ + YD + Sbjct: 184 KISIVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAA 243 Query: 330 KHF---DLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTR 379 K F + Q ++ + + ++ + S SY ATA++DRT+ WT+ Sbjct: 244 KTFIEEEAFQGHSDWVRDVAWSPSRL--SKSY------IATASQDRTVLIWTK 288 Score = 33.5 bits (75), Expect = 0.19, Method: Compositional matrix adjust. Identities = 40/172 (23%), Positives = 77/172 (44%), Gaps = 21/172 (12%) Query: 96 IPAIQWTPE--GRRLVVATYSGEFSL--WNASSFTFETLMQAHDSAVTTMKYS-----HD 146 + ++ W P G L+ A+ G+ S+ + ++Q H V ++ + Sbjct: 162 VNSVSWAPHEYGPVLLCASSDGKISIVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDN 221 Query: 147 SDWMISGDADGMIKIWQPNFS----MVKEIDAAHTESIRDMAFSS---NDSKFVTCSDDN 199 + +SG D ++KIW+ + + + +E H++ +RD+A+S + S T S D Sbjct: 222 TRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDR 281 Query: 200 ILKIW---NFSNGKQERVLSGHHW-DVK-SCDWHPEMGLIASASKDNLVKLW 246 + IW SN +++ L+ + DV W ++A + DN V LW Sbjct: 282 TVLIWTKDGKSNKWEKQPLTKEKFPDVCWRASWSLSGNVLAISGGDNKVTLW 333 >4U1E-I nrPDB Length = 347 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 48/214 (22%), Positives = 93/214 (43%), Gaps = 21/214 (9%) Query: 175 AHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLI 234 H + + ++ +CS D+ +W NG++ L GH + S D Sbjct: 8 GHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCFTKYC 67 Query: 235 ASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKD-----KSCRVF 289 + S D +KLWD +G C+++ K V + F P GN +AI + S ++ Sbjct: 68 VTGSADYSIKLWDVSNGQCVAT-WKSPVPVKRVEFSPC-GNYFLAILDNVMKNPGSINIY 125 Query: 290 DIRY--SMKELMCVRDETDYMTLEWHPINESM---------FTLACY-DGSLKHFDLLQN 337 +I + EL V +E + + ++ + + +A + DG + +D+ N Sbjct: 126 EIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKYDVSNN 185 Query: 338 LNEPILTIPYAHDKCITSLSYNPVGHIFATAAKD 371 E + +I H+K I+ + ++P F T+++D Sbjct: 186 Y-EYVDSIDL-HEKSISDMQFSPDLTYFITSSRD 217 >5WLC-LU nrPDB Length = 489 Score = 48.1 bits (113), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 56/261 (21%), Positives = 106/261 (40%), Gaps = 44/261 (16%) Query: 150 MISGDADGMIKIWQPNFSMVKEIDA--AHTESIRDMAFSS---NDSK--------FVTCS 196 + +G ADG+IK W N S +E + AH + + + +D K ++CS Sbjct: 83 LATGSADGVIKYW--NMSTREEFVSFKAHYGLVTGLCVTQPRFHDKKPDLKSQNFMLSCS 140 Query: 197 DDNILKIW-----NFSNGKQE------------RVLSGHHWDVKSCDWHPEMGLIASASK 239 DD +K+W ++SN R G + D H E A+ Sbjct: 141 DDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESA-FQGIDSHRENSTFATGGA 199 Query: 240 DNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRY---SMK 296 + LWD +S + + +F + ++L + D S ++D+R + K Sbjct: 200 K--IHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSDNSIVLYDLRTNSPTQK 257 Query: 297 ELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSL 356 + +R + W+P+ F A D + ++D ++NL+ L + H + + Sbjct: 258 IVQTMRTN----AICWNPMEAFNFVTANEDHNAYYYD-MRNLSRS-LNVFKDHVSAVMDV 311 Query: 357 SYNPVGHIFATAAKDRTIRFW 377 ++P G T + D++IR + Sbjct: 312 DFSPTGDEIVTGSYDKSIRIY 332 Score = 36.6 bits (83), Expect = 0.026, Method: Compositional matrix adjust. Identities = 19/69 (27%), Positives = 34/69 (49%), Gaps = 7/69 (10%) Query: 99 IQWTPEGRRLVVATYSGEFSLWNA----SSFTFETLMQAHDSAVTTMKYSHDSDWMISGD 154 + ++P G +V +Y ++ S + T H V +KYS DS ++ISG Sbjct: 311 VDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIYHTKRMQH---VFQVKYSMDSKYIISGS 367 Query: 155 ADGMIKIWQ 163 DG +++W+ Sbjct: 368 DDGNVRLWR 376 Score = 34.7 bits (78), Expect = 0.086, Method: Compositional matrix adjust. Identities = 20/78 (25%), Positives = 42/78 (53%), Gaps = 5/78 (6%) Query: 130 LMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIR---DMAFS 186 + + H SAV + +S D +++G D I+I++ N +EI HT+ ++ + +S Sbjct: 300 VFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREI--YHTKRMQHVFQVKYS 357 Query: 187 SNDSKFVTCSDDNILKIW 204 + ++ SDD +++W Sbjct: 358 MDSKYIISGSDDGNVRLW 375 >4YCZ-A nrPDB Length = 876 Score = 47.8 bits (112), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 58/234 (24%), Positives = 103/234 (44%), Gaps = 41/234 (17%) Query: 105 GRRLVVATYSGEFSLWNASSFTFETLM--QAHDSAVTTMKYS-HDSDWMIS-GDADGMIK 160 G L A Y G+ +W + ++ + H ++V + +S H++ +++ +DG + Sbjct: 76 GNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNVS 135 Query: 161 IWQ-PNFSMVKEIDAAHTESIRDMAF-----------------SSNDSKFVTCSDDNILK 202 + + + S I AH + +++ S+ + +FVT DN LK Sbjct: 136 VLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNALK 195 Query: 203 IWNFSNG----KQERV-LSGHHWDVKSCDWHP---EMGLIASASKDNLVKLW-----DPR 249 IW + K ER L+GH V+ W P + IASAS+D V++W +P Sbjct: 196 IWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPANPL 255 Query: 250 SGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMK-ELMCVR 302 NC +L F V + + GN+L A D ++ + ++K E CV+ Sbjct: 256 QWNC--KVLNFDAAVWRVSWS-LSGNVLAASGGDNKVTLW--KENLKGEWECVK 304 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 61/248 (24%), Positives = 97/248 (39%), Gaps = 42/248 (16%) Query: 173 DAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERV---LSGHHWDVKSCDW-H 228 ++ H + I D + TCS D +KI+ G+ +R+ L GH V W H Sbjct: 14 NSGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEI-EGETQRLTETLKGHDGAVWCVSWAH 72 Query: 229 PEMG-LIASASKDNLVKLWDPRSGNCISSILKF---KHTVLKTRFQP-TKGNLLMAISKD 283 P+ G ++ASA D V +W +G I F K +V + P G LL S D Sbjct: 73 PKYGNILASAGYDGKVLIWRELNG-AWQRIFDFALHKASVNVVSWSPHEAGCLLACASSD 131 Query: 284 KSCRVFDIR-YSMKELMCVRDETDYMTLEWHP----------------INESMFTLACYD 326 + V + R S + + ++ W P F D Sbjct: 132 GNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSD 191 Query: 327 GSLK--HFDLLQNL----NEPILTIPYAHDKCITSLSYNPV---GHIFATAAKDRTIRFW 377 +LK +D N EP+ H + ++++P A+A++DRT+R W Sbjct: 192 NALKIWAYDPATNTYKLEREPLT----GHTDWVRDVAWSPTVLQKSYIASASEDRTVRIW 247 Query: 378 TRARPIDP 385 T + P +P Sbjct: 248 T-SDPANP 254 >6J6H-n nrPDB Length = 455 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 39/167 (23%), Positives = 71/167 (42%), Gaps = 4/167 (2%) Query: 213 RVLSGHHWDVKSCDWHPEMG-LIASASKDNLVKLWD-PRSGNCISSILKFKHTVLKTRFQ 270 R GH + + P+ G LI S D+ +K+WD C+ + RF Sbjct: 156 RNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFT 215 Query: 271 PTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLK 330 + L + S D+S +++D + + T +E P N F + + + Sbjct: 216 EDCQSFLSS-SFDRSVKIWDTETGKVKTRLHLNSTP-ADVESRPTNPHEFIVGLSNSKIL 273 Query: 331 HFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 H+D + N+ ++ H I +L Y P G F ++++D+T+R W Sbjct: 274 HYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 38/166 (22%), Positives = 82/166 (49%), Gaps = 12/166 (7%) Query: 133 AHDSAVTTMKYSHDSDWMI-SGDADGMIKIWQ--PNFSMVKEIDAAHTESIRDMAFSSND 189 H T +K+ + +I SG D IKIW ++ +++ H + I+ + F+ + Sbjct: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDF-QGHNKPIKALRFTEDC 218 Query: 190 SKFVTCSDDNILKIWNFSNGK-QERV-LSGHHWDVKSCDWHPEMGLIASASKDNLVKLWD 247 F++ S D +KIW+ GK + R+ L+ DV+S +P ++ + ++ + +D Sbjct: 219 QSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLS--NSKILHYD 276 Query: 248 PRSGNCISSILKFKH---TVLKTRFQPTKGNLLMAISKDKSCRVFD 290 R + + H ++L ++ P G+ ++ S+DK+ R+++ Sbjct: 277 DRVSENQGLVQTYDHHLSSILALKYFP-DGSKFISSSEDKTVRIWE 321 Score = 28.5 bits (62), Expect = 5.8, Method: Compositional matrix adjust. Identities = 26/120 (21%), Positives = 52/120 (43%), Gaps = 3/120 (2%) Query: 131 MQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDS 190 Q H+ + ++++ D +S D +KIW VK ++ + +N Sbjct: 202 FQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPH 261 Query: 191 KF-VTCSDDNILKIWNFSNGKQERVLS-GHHW-DVKSCDWHPEMGLIASASKDNLVKLWD 247 +F V S+ IL + + Q V + HH + + + P+ S+S+D V++W+ Sbjct: 262 EFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321 >6BX3-A nrPDB Length = 314 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 57/255 (22%), Positives = 110/255 (43%), Gaps = 41/255 (16%) Query: 99 IQWTPEGRRLVVATYSGEFS--LWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDAD 156 + W+P+G+ +AT S +FS + + S T + H + V ++ ++ + + + D Sbjct: 60 LCWSPDGQ--CIATASDDFSVEIIHLSYGLLHTFI-GHTAPVISLTFNRKGNLLFTSSMD 116 Query: 157 GMIKIWQP-NFSMVKEIDAAHTESIRDMAFSSNDSKFVTC-SDDNILKIWNFSNGKQERV 214 IKIW N S++K I +AH+E++ + NDS ++ S D +++I++ G + Sbjct: 117 ESIKIWDTLNGSLMKTI-SAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKT 175 Query: 215 LSGHHWDVKSCDWHPEMGLIASA--------------SKDNLVKLWDPRSGNCISSILKF 260 L+ DW E G++ + S D +VK+WD G C+ + Sbjct: 176 LTYDK------DWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCI-GGCVVRTFQV 228 Query: 261 K--------HTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYM---- 308 + H+ P G+ + IS ++ ++ K L+ + D + Y Sbjct: 229 QPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSP 288 Query: 309 TLEWHPINESMFTLA 323 + H M +LA Sbjct: 289 VMSIHCFGNIMCSLA 303 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 28/121 (23%), Positives = 56/121 (46%), Gaps = 1/121 (0%) Query: 170 KEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHP 229 + + +H ++ +S + T SDD ++I + S G + GH V S ++ Sbjct: 47 QTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYGLLHTFI-GHTAPVISLTFNR 105 Query: 230 EMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVF 289 + L+ ++S D +K+WD +G+ + +I V+ ++L + S D R+F Sbjct: 106 KGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIF 165 Query: 290 D 290 D Sbjct: 166 D 166 >4BZK-B nrPDB Length = 297 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 37/128 (28%), Positives = 56/128 (43%), Gaps = 7/128 (5%) Query: 172 IDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERV--LSGHHWDVKSCDW-H 228 I AH E I D + TCS D +KI+ + + L+GH V DW H Sbjct: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 Query: 229 PEMG-LIASASKDNLVKLWDPRSGNCISSILKFKH--TVLKTRFQPTK-GNLLMAISKDK 284 P+ G ++AS S D V +W +G + H +V ++ P + G LL+ S D Sbjct: 64 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 Query: 285 SCRVFDIR 292 V + + Sbjct: 124 KVSVVEFK 131 Score = 37.7 bits (86), Expect = 0.011, Method: Compositional matrix adjust. Identities = 33/110 (30%), Positives = 49/110 (44%), Gaps = 11/110 (10%) Query: 191 KFVTCSDDNILKIWNFSNGKQ----ERVLSGHHWDVKSCDWHPEMGL---IASASKDNLV 243 KFVT DN++KIW +++ Q E L GH V+ W P + L +AS S+D Sbjct: 172 KFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTC 231 Query: 244 KLW--DPRSGNCISSILKFKH--TVLKTRFQPTKGNLLMAISKDKSCRVF 289 +W D G ++LK + VL GN+L D ++ Sbjct: 232 IIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 >4OWR-A nrPDB Length = 339 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 30/110 (27%), Positives = 52/110 (47%), Gaps = 5/110 (4%) Query: 147 SDWMISGDADGMIKIW--QPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIW 204 +++I+G ++ W Q + + + HT + D+ +S + SK T S D K+W Sbjct: 25 GNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMW 84 Query: 205 NFSNGKQERVLSGHHWDVKSCDW--HPEMGLIASASKDNLVKLWDPRSGN 252 + S+ Q ++ H VK+ W P + + S D +K WD RS N Sbjct: 85 DLSS-NQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSN 133 Score = 32.7 bits (73), Expect = 0.33, Method: Compositional matrix adjust. Identities = 60/287 (20%), Positives = 107/287 (37%), Gaps = 28/287 (9%) Query: 105 GRRLVVATYSGEFSLWNA--SSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIW 162 G L+ +++ + W S T Q H V + +S D + + D K+W Sbjct: 25 GNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMW 84 Query: 163 QPNFSMVKEIDAAHTESIRDMAF--SSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHW 220 + + +I A H ++ + + + N S +T S D LK W+ + VL Sbjct: 85 DLSSNQAIQI-AQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPE- 142 Query: 221 DVKSCDWHPEMGLIASASKDNLVKLWD--PRSGNCISSILKFKH---TVLKTRFQPTKGN 275 D M ++A+A + +V + P I S LK +H + K + G Sbjct: 143 RCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHRCVAIFKDKQNKPTGF 202 Query: 276 LLMAISKDKSCRVFDIRYSMKE---LMCVR----------DETDYMTLEWHPINESMFTL 322 L +I + + K+ C R D + +HP++ ++ T+ Sbjct: 203 ALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVHGTLATV 262 Query: 323 ACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAA 369 GS F L D+ I++ +N G+IFA A+ Sbjct: 263 ----GSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYAS 305 >3JRP-A nrPDB Length = 379 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 37/128 (28%), Positives = 56/128 (43%), Gaps = 7/128 (5%) Query: 172 IDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERV--LSGHHWDVKSCDW-H 228 I AH E I D + TCS D +KI+ + + L+GH V DW H Sbjct: 6 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 65 Query: 229 PEMG-LIASASKDNLVKLWDPRSGNCISSILKFKH--TVLKTRFQPTK-GNLLMAISKDK 284 P+ G ++AS S D V +W +G + H +V ++ P + G LL+ S D Sbjct: 66 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 125 Query: 285 SCRVFDIR 292 V + + Sbjct: 126 KVSVVEFK 133 Score = 37.7 bits (86), Expect = 0.010, Method: Compositional matrix adjust. Identities = 27/78 (34%), Positives = 39/78 (50%), Gaps = 9/78 (11%) Query: 191 KFVTCSDDNILKIWNFSNGKQ----ERVLSGHHWDVKSCDWHPEMGL---IASASKDNLV 243 KFVT DN++KIW +++ Q E L GH V+ W P + L +AS S+D Sbjct: 174 KFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTC 233 Query: 244 KLW--DPRSGNCISSILK 259 +W D G ++LK Sbjct: 234 IIWTQDNEQGPWKKTLLK 251 >3JRO-A nrPDB Length = 753 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 37/128 (28%), Positives = 56/128 (43%), Gaps = 7/128 (5%) Query: 172 IDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERV--LSGHHWDVKSCDW-H 228 I AH E I D + TCS D +KI+ + + L+GH V DW H Sbjct: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 Query: 229 PEMG-LIASASKDNLVKLWDPRSGNCISSILKFKH--TVLKTRFQPTK-GNLLMAISKDK 284 P+ G ++AS S D V +W +G + H +V ++ P + G LL+ S D Sbjct: 64 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 Query: 285 SCRVFDIR 292 V + + Sbjct: 124 KVSVVEFK 131 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 27/78 (34%), Positives = 39/78 (50%), Gaps = 9/78 (11%) Query: 191 KFVTCSDDNILKIWNFSNGKQ----ERVLSGHHWDVKSCDWHPEMGL---IASASKDNLV 243 KFVT DN++KIW +++ Q E L GH V+ W P + L +AS S+D Sbjct: 172 KFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTC 231 Query: 244 KLW--DPRSGNCISSILK 259 +W D G ++LK Sbjct: 232 IIWTQDNEQGPWKKTLLK 249 >5K0Y-T nrPDB Length = 329 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 46/220 (20%), Positives = 86/220 (39%), Gaps = 29/220 (13%) Query: 175 AHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLI 234 H SI + ++ T + D I+ +W NG++ GH V D + + Sbjct: 8 GHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHV 67 Query: 235 ASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYS 294 + S DN +LWD +G + ++LK V F ++ + K + F + Sbjct: 68 LTGSADNSCRLWDCETGKQL-ALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFD 126 Query: 295 MKELMCVRDETDYMTLEWHPINESMFTLACY------------DGSLKHF-----DLLQN 337 +++ + + YM + P N+S T A + G L + ++L N Sbjct: 127 LRDPSQIDNNEPYMKI---PCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVN 183 Query: 338 LNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 + E H + I + + +F TA+KD T + + Sbjct: 184 VKE--------HSRQINDIQLSREMTMFVTASKDNTAKLF 215 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 22/98 (22%), Positives = 47/98 (47%), Gaps = 1/98 (1%) Query: 130 LMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSND 189 L+Q H+ ++T +KY+ + D + + D ++ +W HT ++ + + Sbjct: 5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDT 64 Query: 190 SKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDW 227 +T S DN ++W+ GKQ +L + V++C + Sbjct: 65 KHVLTGSADNSCRLWDCETGKQLALLKTNS-AVRTCGF 101 Score = 36.6 bits (83), Expect = 0.024, Method: Compositional matrix adjust. Identities = 39/157 (24%), Positives = 69/157 (43%), Gaps = 11/157 (7%) Query: 214 VLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTK 273 +L GH + ++ E L+ + +KD +V +W +G + + + V Sbjct: 5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDT 64 Query: 274 GNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEW-HPINESMFTL---ACYDGSL 329 ++L S D SCR++D + K+L ++ + T + N MF+ Y + Sbjct: 65 KHVLTG-SADNSCRLWDCE-TGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFV 122 Query: 330 KHFDLLQ----NLNEPILTIPYAHDKCITSLSYNPVG 362 FDL + NEP + IP +D ITS + P+G Sbjct: 123 SFFDLRDPSQIDNNEPYMKIP-CNDSKITSAVWGPLG 158 Score = 32.0 bits (71), Expect = 0.62, Method: Compositional matrix adjust. Identities = 34/171 (19%), Positives = 67/171 (39%), Gaps = 19/171 (11%) Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDA 155 I + W P G ++ SGE + ++A S ++ H + ++ S + ++ Sbjct: 149 ITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSREMTMFVTASK 208 Query: 156 DGMIKIWQPNFSMVKEIDAAHTESIRDM-AFSSNDSKFVTCSDDNILKIWNFSN--GKQE 212 D K++ + ++ TE R++ A S N V + + S GK E Sbjct: 209 DNTAKLFDS--TTLEHQKTFRTEPPRELAALSPNYEHVVVGGGQEAMDVTTTSTRIGKFE 266 Query: 213 R------------VLSGHHWDVKSCDWHPEMGLIASASKDNLVKL--WDPR 249 + GH + S +HP+ +S +D V++ +DP+ Sbjct: 267 ARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRIHYFDPQ 317 Score = 30.0 bits (66), Expect = 2.1, Method: Compositional matrix adjust. Identities = 18/73 (24%), Positives = 33/73 (45%) Query: 133 AHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKF 192 +DS +T+ + + +I+G G + + V H+ I D+ S + F Sbjct: 144 CNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSREMTMF 203 Query: 193 VTCSDDNILKIWN 205 VT S DN K+++ Sbjct: 204 VTASKDNTAKLFD 216 >5WJC-A nrPDB Length = 430 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 42/173 (24%), Positives = 73/173 (42%), Gaps = 35/173 (20%) Query: 212 ERVLSGHHWDVKSCDWHPEM-GLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQ 270 + VL GH + W+P + G +A+ ++D ++ LWD ++ + SS K + K Sbjct: 175 QAVLKGHTAEGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYH-- 232 Query: 271 PTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLK 330 R DI V D +++HP +E++ D +L+ Sbjct: 233 ----------------RHTDI---------VND------VQFHPQHEALLASVSDDCTLQ 261 Query: 331 HFDLLQNLNEPILTIPYAHDKCITSLSYNPVG-HIFATAAKDRTIRFWTRARP 382 D N E + AH K I +++ NP ++ ATA+ D+T+ W P Sbjct: 262 IHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALWDLRNP 314 Score = 32.3 bits (72), Expect = 0.47, Method: Compositional matrix adjust. Identities = 26/138 (18%), Positives = 62/138 (44%), Gaps = 20/138 (14%) Query: 130 LMQAHDSAVTTMKYSHDSDWMIS-GDADGMIKIWQPN--FSMVKEIDAAHTESIRDMAFS 186 ++QAH A+ + + +D++++ AD + +W + + ++ H + + + +S Sbjct: 276 VIQAHSKAINAVAINPFNDYLLATASADKTVALWDLRNPYQRLHTLEG-HEDEVYGLEWS 334 Query: 187 SNDSKFV-TCSDDNILKIWNFSNGKQER--------------VLSGHHWDVKSCDWHP-E 230 +D + + S D + IW+ +E+ + GH + W P E Sbjct: 335 PHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPNE 394 Query: 231 MGLIASASKDNLVKLWDP 248 ++ S + DN++++W P Sbjct: 395 RWVVGSLADDNILQIWSP 412 >3JB9-g nrPDB Length = 558 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 47/212 (22%), Positives = 77/212 (36%), Gaps = 49/212 (23%) Query: 175 AHTESIRDMAFSS-NDSKFVTCSDDNILKIWNFSNGKQE-RVLSGHHWDVKSCDWHPEMG 232 HT+ I + F + ++ S DN +KIW + + R GH ++ + + Sbjct: 264 GHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQDGR 323 Query: 233 LIASASKDNLVKLWDPRSGNCISSILKFKHT-VLKTRFQPTKGNLLMAISKDKSCRVFDI 291 S S D +KLWD G C++ + T +K + P K N +A + DK FDI Sbjct: 324 SFLSTSFDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGTADKRILQFDI 383 Query: 292 RYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDK 351 R D++Q + H Sbjct: 384 RSP--------------------------------------DIVQAYDH--------HLG 397 Query: 352 CITSLSYNPVGHIFATAAKDRTIRFWTRARPI 383 I S+++ G F T + D ++RFW P+ Sbjct: 398 GINSITFLENGKRFVTTSDDSSMRFWEYGTPV 429 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 23/82 (28%), Positives = 44/82 (53%), Gaps = 4/82 (4%) Query: 132 QAHDSAVTTMKYSHDSD-WMISGDADGMIKIWQP--NFSMVKEIDAAHTESIRDMAFSSN 188 + H ++ +++ S ++SG D IKIW+ + S+++ H IRD++FS + Sbjct: 263 KGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQG-HARPIRDLSFSQD 321 Query: 189 DSKFVTCSDDNILKIWNFSNGK 210 F++ S D +K+W+ GK Sbjct: 322 GRSFLSTSFDKTIKLWDTELGK 343 Score = 34.7 bits (78), Expect = 0.090, Method: Compositional matrix adjust. Identities = 24/115 (20%), Positives = 46/115 (40%), Gaps = 4/115 (3%) Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSD---WMIS 152 I + ++ +GR + ++ LW+ + D +K+ D D ++ Sbjct: 313 IRDLSFSQDGRSFLSTSFDKTIKLWDTELGKCLNCFNS-DRLTNCVKFQVDPDKPNEFLA 371 Query: 153 GDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFS 207 G AD I + + + H I + F N +FVT SDD+ ++ W + Sbjct: 372 GTADKRILQFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYG 426 Score = 30.4 bits (67), Expect = 1.9, Method: Compositional matrix adjust. Identities = 17/66 (25%), Positives = 27/66 (40%), Gaps = 2/66 (3%) Query: 99 IQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKY--SHDSDWMISGDAD 156 + ++P+GR + SG W+ + + AH V +M + S S D Sbjct: 492 VGFSPDGRFVFSGDSSGNACFWDWKTCKLMAKLPAHSGPVQSMAFHPQETSKVATSSIVD 551 Query: 157 GMIKIW 162 G IK W Sbjct: 552 GSIKYW 557 >5A9Q-0 nrPDB Length = 380 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 37/155 (23%), Positives = 70/155 (45%), Gaps = 8/155 (5%) Query: 150 MISGDADGMIKIWQPNF-SMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSN 208 +++ DG I +++ + V+ ID A + ++ + F + +T + LKIW+F Sbjct: 144 IVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRT-PEILTVNSIGQLKIWDFRQ 202 Query: 209 GKQE----RVLSGHHWDVKSCDWHP-EMGLIASASKDNLVKLWDPRSGNCISSILKFKHT 263 E L+G + D HP + ++A+ +D ++ +WD R G S+LK Sbjct: 203 QGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEA 262 Query: 264 VL-KTRFQPTKGNLLMAISKDKSCRVFDIRYSMKE 297 + + F P+ L S+D S +D + E Sbjct: 263 EMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPE 297 Score = 30.4 bits (67), Expect = 1.8, Method: Compositional matrix adjust. Identities = 20/66 (30%), Positives = 31/66 (46%), Gaps = 2/66 (3%) Query: 150 MISGDADGMIKIWQP-NFSMVKEIDAAHTESIRDMAFS-SNDSKFVTCSDDNILKIWNFS 207 + +G DGM+ IW +M + AH + ++ F SN TCS+D L W+ S Sbjct: 233 VATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDAS 292 Query: 208 NGKQER 213 E+ Sbjct: 293 TDVPEK 298 >2PM9-A nrPDB Length = 416 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 34/123 (27%), Positives = 54/123 (43%), Gaps = 11/123 (8%) Query: 193 VTCSD-DNILKIWNFSNGKQ--ERVLSGHHWDVKSCDW-HPEMGLIASASKDNLVKLWDP 248 T SD D + IW+ N + + GH + S DW H + L+ S+ +DN V LW+P Sbjct: 233 ATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNP 292 Query: 249 RSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYM 308 S +S + KT+F P +L +C FD + ++ L + + D Sbjct: 293 ESAEQLSQFPARGNWCFKTKFAPEAPDLF-------ACASFDNKIEVQTLQNLTNTLDEQ 345 Query: 309 TLE 311 E Sbjct: 346 ETE 348 Score = 37.0 bits (84), Expect = 0.017, Method: Compositional matrix adjust. Identities = 23/72 (31%), Positives = 37/72 (51%), Gaps = 5/72 (6%) Query: 310 LEWHPINESMFTLAC---YDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSY-NPVGHIF 365 +EWHP N + A D S+ +DL +N N P+ T+ H K I SL + + H+ Sbjct: 220 VEWHPKNSTRVATATGSDNDPSILIWDL-RNANTPLQTLNQGHQKGILSLDWCHQDEHLL 278 Query: 366 ATAAKDRTIRFW 377 ++ +D T+ W Sbjct: 279 LSSGRDNTVLLW 290 >5CXC-A nrPDB Length = 510 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 77/355 (21%), Positives = 134/355 (37%), Gaps = 79/355 (22%) Query: 103 PEGRRLVVATYSGEFSLWNASSFTFET----LMQAHDSAVTTMKYSHDSDWMISGDADGM 158 P R++ A+Y G +WNAS T H +++ K+ SD + S D Sbjct: 156 PGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKF-LTSDRLASAGMDRT 214 Query: 159 IKIWQPNFS--MVKEIDA-----AHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQ 211 +++W+ S E+ HT S+ + + +T S D + W+ S Sbjct: 215 VRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSASKASA 274 Query: 212 ----ERVLSGHH---------------------WDVKSCD-----WHPEMGLIA-SASKD 240 +L G H W + + + P +A SAS+D Sbjct: 275 PEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQD 334 Query: 241 NLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGN---LLMAISKDKSCRVFDIRYS--M 295 + V+ D +G +S+ L H +L G LL A + + + D R S Sbjct: 335 HTVRTLDLTTGQVVST-LTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDPRASSAT 393 Query: 296 KELMCVRDETD-YMTLEWHPINESMFTLACYDGSLKHFDL------------LQNLNEPI 342 +M +R + ++L P NE +DG+ + +DL L ++EP+ Sbjct: 394 TSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKEEGSLGGVSEPV 453 Query: 343 LTI-------------PYAHDKC-ITSLSYNPVGHIFATAAKDRTIRFWTRARPI 383 I P A D C + S+ ++ +G IF + +D+ ++ R R I Sbjct: 454 YVIERESWASKGKKKRPVAGDGCKVFSVVWDKLG-IF-SGGEDKKVQV-NRGRNI 505 >5YZG-W nrPDB Length = 579 Score = 44.7 bits (104), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 29/133 (21%), Positives = 64/133 (48%), Gaps = 7/133 (5%) Query: 79 NLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASS---FTFETLMQAHD 135 ++P F +++ + H +PA+ +P G+ L + + ++ A + + + + H Sbjct: 448 DIPVDFKYIAEPSM-HSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHM 506 Query: 136 SA--VTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSND-SKF 192 A + +S D ++ISGD +G + IW + + AH + + ++ SK Sbjct: 507 VAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKV 566 Query: 193 VTCSDDNILKIWN 205 +TC D ++K+W+ Sbjct: 567 ITCGWDGLIKLWD 579 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 32/144 (22%), Positives = 63/144 (43%), Gaps = 4/144 (2%) Query: 150 MISGDADGMIKIWQP-NFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSN 208 ++S D IK+W+ H++++RD+ F++ ++F++ + D LK+W+ Sbjct: 304 LLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTET 363 Query: 209 GKQERVLSGHH--WDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLK 266 G+ + + VK + L + D + WD RSG + + V Sbjct: 364 GQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNT 423 Query: 267 TRFQPTKGNLLMAISKDKSCRVFD 290 F + ++ S DKS RV++ Sbjct: 424 IVFV-DENRRFVSTSDDKSLRVWE 446 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 44/223 (19%), Positives = 80/223 (35%), Gaps = 51/223 (22%) Query: 174 AAHTESIRDM-AFSSNDSKFVTCSDDNILKIWN-FSNGKQERVLSGHHWDVKSCDWHPEM 231 + HT+ + + F + ++CS D +K+W + + R GH V+ ++ Sbjct: 285 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAG 344 Query: 232 GLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPT--KGNLLMAISKDKSCRVF 289 SA+ D +KLWD +G CIS K +F P K NL +A DK + Sbjct: 345 TQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYC-VKFNPDEDKQNLFVAGMSDKKIVQW 403 Query: 290 DIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAH 349 DIR +++Q + H Sbjct: 404 DIRSG--------------------------------------EIVQEYDR--------H 417 Query: 350 DKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYDDPT 392 + ++ + F + + D+++R W P+D +P+ Sbjct: 418 LGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPS 460 Score = 33.5 bits (75), Expect = 0.21, Method: Compositional matrix adjust. Identities = 26/107 (24%), Positives = 51/107 (47%), Gaps = 8/107 (7%) Query: 105 GRRLVVATYSGEFSLWNASSFTFETLMQAHDSAV-TTMKYSHDSD---WMISGDADGMIK 160 G + + A Y LW+ T + + + + V +K++ D D ++G +D I Sbjct: 344 GTQFLSAAYDRYLKLWDTE--TGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIV 401 Query: 161 IWQ-PNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNF 206 W + +V+E D H ++ + F + +FV+ SDD L++W + Sbjct: 402 QWDIRSGEIVQEYDR-HLGAVNTIVFVDENRRFVSTSDDKSLRVWEW 447 >6QDV-o nrPDB Length = 513 Score = 44.7 bits (104), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 29/133 (21%), Positives = 64/133 (48%), Gaps = 7/133 (5%) Query: 79 NLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASS---FTFETLMQAHD 135 ++P F +++ + H +PA+ +P G+ L + + ++ A + + + + H Sbjct: 382 DIPVDFKYIAEPSM-HSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHM 440 Query: 136 SA--VTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSND-SKF 192 A + +S D ++ISGD +G + IW + + AH + + ++ SK Sbjct: 441 VAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKV 500 Query: 193 VTCSDDNILKIWN 205 +TC D ++K+W+ Sbjct: 501 ITCGWDGLIKLWD 513 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 32/144 (22%), Positives = 63/144 (43%), Gaps = 4/144 (2%) Query: 150 MISGDADGMIKIWQP-NFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSN 208 ++S D IK+W+ H++++RD+ F++ ++F++ + D LK+W+ Sbjct: 238 LLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTET 297 Query: 209 GKQERVLSGHH--WDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLK 266 G+ + + VK + L + D + WD RSG + + V Sbjct: 298 GQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNT 357 Query: 267 TRFQPTKGNLLMAISKDKSCRVFD 290 F + ++ S DKS RV++ Sbjct: 358 IVF-VDENRRFVSTSDDKSLRVWE 380 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 44/223 (19%), Positives = 80/223 (35%), Gaps = 51/223 (22%) Query: 174 AAHTESIRDM-AFSSNDSKFVTCSDDNILKIWN-FSNGKQERVLSGHHWDVKSCDWHPEM 231 + HT+ + + F + ++CS D +K+W + + R GH V+ ++ Sbjct: 219 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAG 278 Query: 232 GLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPT--KGNLLMAISKDKSCRVF 289 SA+ D +KLWD +G CIS K +F P K NL +A DK + Sbjct: 279 TQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYC-VKFNPDEDKQNLFVAGMSDKKIVQW 337 Query: 290 DIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAH 349 DIR +++Q + H Sbjct: 338 DIRSG--------------------------------------EIVQEYDR--------H 351 Query: 350 DKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYDDPT 392 + ++ + F + + D+++R W P+D +P+ Sbjct: 352 LGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPS 394 Score = 33.5 bits (75), Expect = 0.20, Method: Compositional matrix adjust. Identities = 26/107 (24%), Positives = 51/107 (47%), Gaps = 8/107 (7%) Query: 105 GRRLVVATYSGEFSLWNASSFTFETLMQAHDSAV-TTMKYSHDSD---WMISGDADGMIK 160 G + + A Y LW+ T + + + + V +K++ D D ++G +D I Sbjct: 278 GTQFLSAAYDRYLKLWDTE--TGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIV 335 Query: 161 IWQ-PNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNF 206 W + +V+E D H ++ + F + +FV+ SDD L++W + Sbjct: 336 QWDIRSGEIVQEYDR-HLGAVNTIVFVDENRRFVSTSDDKSLRVWEW 381 >5OQL-L nrPDB Length = 557 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 21/76 (27%), Positives = 40/76 (52%), Gaps = 5/76 (6%) Query: 190 SKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMG---LIASASKDNLVKLW 246 + ++CSDD +++W+ + R+ +GH V+ + P L+ S S D V++W Sbjct: 158 TTLMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVW 217 Query: 247 DPRSGNCISSILKFKH 262 D R+ +++ FKH Sbjct: 218 DARAPG--GAVMTFKH 231 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 45/192 (23%), Positives = 76/192 (39%), Gaps = 11/192 (5%) Query: 192 FVTCSDDNILKIWNFSNGKQERVLSG---HHWDVKSCDWHP-EMGLIASASKDNLVKLWD 247 V D +++++ G + +L H V W P E+ + S S D V+LWD Sbjct: 114 LVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWD 173 Query: 248 PRSGNCISSILKFKHTVLKTRFQPTKGN--LLMAISKDKSCRVFDIRYSMKELMCVRDET 305 S + V F P N LL++ S D++ RV+D R +M + Sbjct: 174 LPSNDPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVMTFKHAD 233 Query: 306 DYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIF 365 + P+ LA ++ DL+ +P+ I H K +TSLS G Sbjct: 234 PIEDV--LPLPSGTTLLAASGNAISVLDLVA--AKPLRLITN-HQKTVTSLSLASQGRRV 288 Query: 366 ATAAKDRTIRFW 377 + + D ++ + Sbjct: 289 VSGSLDGHVKVF 300 Score = 37.0 bits (84), Expect = 0.017, Method: Compositional matrix adjust. Identities = 34/161 (21%), Positives = 65/161 (40%), Gaps = 5/161 (3%) Query: 100 QWTP-EGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTT---MKYSHDSDWMISGDA 155 +W+P E L+ + LW+ S L H V M S +S+ ++SG Sbjct: 151 KWSPTELTTLMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSY 210 Query: 156 DGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVL 215 D +++W + H + I D+ + + + S N + + + K R++ Sbjct: 211 DETVRVWDARAPGGAVMTFKHADPIEDVLPLPSGTTLLAAS-GNAISVLDLVAAKPLRLI 269 Query: 216 SGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISS 256 + H V S + + S S D VK+++ S N ++ Sbjct: 270 TNHQKTVTSLSLASQGRRVVSGSLDGHVKVFETTSWNVVAG 310 >6ELZ-p nrPDB Length = 460 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 34/132 (25%), Positives = 59/132 (44%), Gaps = 26/132 (19%) Query: 138 VTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSD 197 V+++ S +ISG DG+++ W + ++ K+ + H+ IR + + SN ++ V+ + Sbjct: 106 VSSLDVGDGSKHIISGSYDGIVRTWDLSGNVQKQY-SGHSGPIRAVKYISN-TRLVSAGN 163 Query: 198 DNILKIW-----------------------NFSNGKQERVLSGHHWDVKSCDWHPEMGLI 234 D L++W N +GK +L GH V S D + I Sbjct: 164 DRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDV-SDNSRI 222 Query: 235 ASASKDNLVKLW 246 SAS DN + W Sbjct: 223 LSASYDNSIGFW 234 Score = 27.7 bits (60), Expect = 10.0, Method: Compositional matrix adjust. Identities = 27/114 (23%), Positives = 50/114 (43%), Gaps = 8/114 (7%) Query: 236 SASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYS- 294 S S+D+ +K WD + CI + + L + Q + NLL S + + D R Sbjct: 305 SVSQDHTIKTWDLVTARCIDT--RTTSYSLLSIAQLSTLNLLACGSSARHITLHDPRVGA 362 Query: 295 ---MKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTI 345 + + + + +L+ P NE + +DG++K +D+ P+ TI Sbjct: 363 SSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRS--TSPMYTI 414 >5MWJ-A nrPDB Length = 337 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 29/119 (24%), Positives = 57/119 (47%), Gaps = 4/119 (3%) Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFT--FETLMQAHDSAVTTMKYSHDSDWMISG 153 I + + P+G L+V + S+W+ ++ T + + + A + S DS S Sbjct: 100 IRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSC 159 Query: 154 DADGMIKIWQ-PNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQ 211 +DG I +W N ++V++ HT+ + S++ +K T DN ++ W+ G+Q Sbjct: 160 CSDGNIAVWDLHNQTLVRQFQ-GHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQ 217 Score = 33.9 bits (76), Expect = 0.17, Method: Compositional matrix adjust. Identities = 43/246 (17%), Positives = 80/246 (32%), Gaps = 53/246 (21%) Query: 135 DSAVTTMKYSHDSDWMISGDADGMIKIWQ---PNFSMVKEIDAAHTESIRDMAFSSNDSK 191 D+ + + K D +I G + IW P + E+ ++ + +A S + Sbjct: 97 DNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSS-APACYALAISPDSKV 155 Query: 192 FVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSG 251 +C D + +W+ N R GH D + + + DN V+ WD R G Sbjct: 156 CFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREG 215 Query: 252 NCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLE 311 + D + ++F + Y T E Sbjct: 216 RQLQQ-------------------------HDFTSQIFSLGYCP-------------TGE 237 Query: 312 WHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKD 371 W + + + ++N+P + H+ C+ SL + G F + KD Sbjct: 238 WLAVGMESSNVE-----------VLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKD 286 Query: 372 RTIRFW 377 + W Sbjct: 287 NLLNAW 292 Score = 32.0 bits (71), Expect = 0.56, Method: Compositional matrix adjust. Identities = 21/109 (19%), Positives = 46/109 (42%), Gaps = 2/109 (1%) Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDA 155 I ++ + P G L V S + + + + + H+S V ++K+++ W +S Sbjct: 227 IFSLGYCPTGEWLAVGMESSNVEVLHVNK-PDKYQLHLHESCVLSLKFAYCGKWFVSTGK 285 Query: 156 DGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIW 204 D ++ W+ + + + S+ S +D VT S D ++ Sbjct: 286 DNLLNAWRTPYG-ASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVY 333 >5A9Q-7 nrPDB Length = 360 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 38/144 (26%), Positives = 61/144 (42%), Gaps = 24/144 (16%) Query: 168 MVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNG------KQERVLSGHHWD 221 + + I A H + I D++F + + TCS D +K+W+ S + SG W Sbjct: 3 VARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWR 62 Query: 222 VKSCDW-HPEMG-LIASASKDNLVKLWDPRSGNCISSILKFKHTVLKT------------ 267 V W HPE G ++AS S D +W+ G + H V +T Sbjct: 63 VT---WAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDV 119 Query: 268 RFQPTKGNLLMA-ISKDKSCRVFD 290 +F P L++A S D R+++ Sbjct: 120 KFAPKHMGLMLATCSADGIVRIYE 143 >3BG0-A nrPDB Length = 316 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 29/90 (32%), Positives = 44/90 (48%), Gaps = 4/90 (4%) Query: 166 FSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERV--LSGHHWDVK 223 S++ +D +H + I D ++ TCS D +KI++ NG Q + L GH V Sbjct: 2 VSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVW 61 Query: 224 SCDW-HPEMG-LIASASKDNLVKLWDPRSG 251 W HP G ++AS S D V +W +G Sbjct: 62 QVAWAHPMYGNILASCSYDRKVIIWREENG 91 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 58/239 (24%), Positives = 100/239 (41%), Gaps = 47/239 (19%) Query: 105 GRRLVVATYSGEFSLWNASSFTFETLMQ--AHDSAVTTMKYS-HDSDWMIS-GDADGMIK 160 G L +Y + +W + T+E + HDS+V ++ ++ HD +++ G +DG I Sbjct: 71 GNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAIS 130 Query: 161 I--------WQPNFSMVKEIDAAHTESIRDMAFS-----------------SNDSKFVTC 195 + W+ VK+I+ AHT ++++ + +F + Sbjct: 131 LLTYTGEGQWE-----VKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASG 185 Query: 196 SDDNILKIWNF---SNGKQERVLSGHHWDVKSCDWHPEMGL----IASASKDNLVKLW-- 246 DN++K+W K+E+ L H V+ W P +GL IAS S+D V +W Sbjct: 186 GCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTC 245 Query: 247 DPRSGNCISSIL--KFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRD 303 D S N S L KF V + T N+L D ++ + +C+ D Sbjct: 246 DDASSNTWSPKLLHKFNDVVWHVSWSIT-ANILAVSGGDNKVTLWKESVD-GQWVCISD 302 >2AQ5-A nrPDB Length = 402 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 29/137 (21%), Positives = 64/137 (46%), Gaps = 11/137 (8%) Query: 130 LMQAHDSAVTTMKYS-HDSDWMISGDADGMIKIWQ-PNFSMVKEIDA------AHTESIR 181 L+ H + V + + H+ + + SG D + +W+ P+ +V + HT+ + Sbjct: 76 LVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVG 135 Query: 182 DMAF-SSNDSKFVTCSDDNILKIWNFSNGKQERVLSG--HHWDVKSCDWHPEMGLIASAS 238 +A+ + + ++ DN++ +W+ G L H + S DW + LI ++ Sbjct: 136 IVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSC 195 Query: 239 KDNLVKLWDPRSGNCIS 255 +D V++ +PR G ++ Sbjct: 196 RDKRVRVIEPRKGTVVA 212 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 35/130 (26%), Positives = 59/130 (45%), Gaps = 12/130 (9%) Query: 174 AAHTESIRDMAFSS-NDSKFVTCSDDNILKIWNFSNGK-----QERV--LSGHHWDVKSC 225 HT + D+A+ ND+ + S+D + +W +G +E V L GH V Sbjct: 78 CGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIV 137 Query: 226 DWHP-EMGLIASASKDNLVKLWDPRSGNCISSILKFKH--TVLKTRFQPTKGNLLMAISK 282 WHP ++ SA DN++ +WD +G + ++ H T+ + G L+ + Sbjct: 138 AWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWS-RDGALICTSCR 196 Query: 283 DKSCRVFDIR 292 DK RV + R Sbjct: 197 DKRVRVIEPR 206 >1NR0-A nrPDB Length = 611 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 49/232 (21%), Positives = 94/232 (40%), Gaps = 33/232 (14%) Query: 107 RLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQP-- 164 R++ + +++ F F++ H V +++Y+ D S DG I ++ Sbjct: 162 RIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVD 221 Query: 165 -NFSMVKEIDA----AHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHH 219 + V E D+ AH+ S+ + +S + +K + S D +KIWN + K E+ + Sbjct: 222 GTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIP--- 278 Query: 220 WDVKSCDWHPEMGLI------ASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTK 273 V + ++G+I S S + + +P G+ +++ H T + Sbjct: 279 --VGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSI--DQVRYGHNKAITALSSSA 334 Query: 274 -GNLLMA-----------ISKDKSCRVF-DIRYSMKELMCVRDETDYMTLEW 312 G L + IS S RVF D+ +M + + D T+ W Sbjct: 335 DGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSW 386 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 59/287 (20%), Positives = 108/287 (37%), Gaps = 52/287 (18%) Query: 102 TPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKI 161 TP G ++ + +++ S T + H T K S + SGD G ++I Sbjct: 27 TPAGDKIQYCNGTSVYTV-PVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRI 85 Query: 162 WQPNFS--MVKEIDAAHTESIRDMAFSSNDSKFVTCSD--DNILKIWNFSNGKQERVLSG 217 W + ++K + ++D+++ S + + + ++ F G L+G Sbjct: 86 WDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTG 145 Query: 218 HHWDVKSCDWHPEMGL-IASASKDNLVKLWDP---RSGNCISSILKFKHTVLKTRFQPTK 273 + S D+ P I S S DN V +++ + + KF H+V R+ P Sbjct: 146 QARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSV---RYNP-D 201 Query: 274 GNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFD 333 G+L + D + +++ D T E D SLK+ Sbjct: 202 GSLFASTGGDGTIVLYN----------GVDGTKTGVFE--------------DDSLKNV- 236 Query: 334 LLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRA 380 AH + L+++P G A+A+ D+TI+ W A Sbjct: 237 --------------AHSGSVFGLTWSPDGTKIASASADKTIKIWNVA 269 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 41/205 (20%), Positives = 77/205 (37%), Gaps = 35/205 (17%) Query: 98 AIQWTPEGRRLVVATYSGEFSLWNASSFTFE------TLMQAHDSAVTTMKYSHDSDWMI 151 + W+P+G ++ A+ +WN ++ E T ++ + K + ++ Sbjct: 244 GLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQA-----LV 298 Query: 152 SGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQ 211 S A+G I P + ++ H ++I ++ S++ + + + W+ S G Sbjct: 299 SISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGIS 358 Query: 212 ERVLSGHHWDVKSCDWHPEM--GLIASASKDNLVKLWD------PRSGNCISSILKFKHT 263 RV D H M G+ ++ D WD P G+ + S K Sbjct: 359 NRVFP---------DVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDS---SKAV 406 Query: 264 VLKTRFQPTKGNLLMAISKDKSCRV 288 K QP L +A+S D V Sbjct: 407 ANKLSSQP----LGLAVSADGDIAV 427 Score = 37.7 bits (86), Expect = 0.010, Method: Compositional matrix adjust. Identities = 50/253 (19%), Positives = 90/253 (35%), Gaps = 18/253 (7%) Query: 52 NLVVEPETSYTIDIMPPNAYR----GRDRVINL----PSKFTHLSSNKVKHVIPAIQWTP 103 NL + ++D P +R D + + P KF K V ++++ P Sbjct: 142 NLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFV-HSVRYNP 200 Query: 104 EGRRLVVATYSGEFSLWNASSFTFETLMQ-------AHDSAVTTMKYSHDSDWMISGDAD 156 +G G L+N T + + AH +V + +S D + S AD Sbjct: 201 DGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASAD 260 Query: 157 GMIKIWQ-PNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVL 215 IKIW + K I + + V+ S + + N G ++V Sbjct: 261 KTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVR 320 Query: 216 SGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGN 275 GH+ + + + + SA + + WD +G + + H + T + T Sbjct: 321 YGHNKAITALSSSADGKTLFSADAEGHINSWDISTG-ISNRVFPDVHATMITGIKTTSKG 379 Query: 276 LLMAISKDKSCRV 288 L +S D +V Sbjct: 380 DLFTVSWDDHLKV 392 Score = 36.2 bits (82), Expect = 0.035, Method: Compositional matrix adjust. Identities = 17/57 (29%), Positives = 27/57 (47%) Query: 349 HDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFFGI 405 H K + S+ YNP G +FA+ D TI + ++D + N +G FG+ Sbjct: 189 HTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGL 245 Score = 32.3 bits (72), Expect = 0.40, Method: Compositional matrix adjust. Identities = 26/113 (23%), Positives = 50/113 (44%), Gaps = 8/113 (7%) Query: 141 MKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDA-AHTESIRDMAFSSNDSKFVTCSDDN 199 + S+D ++ G D + +++ + + V E+ H I +AFS+N + V + D Sbjct: 454 VALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLV--ATDQ 511 Query: 200 ILKIWNFSNGKQERVLSGHHW-----DVKSCDWHPEMGLIASASKDNLVKLWD 247 K+ +S + + W V W P+ +A+ S DN V +W+ Sbjct: 512 SRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWN 564 Score = 31.2 bits (69), Expect = 0.92, Method: Compositional matrix adjust. Identities = 25/106 (23%), Positives = 48/106 (45%), Gaps = 8/106 (7%) Query: 102 TPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKI 161 T + R+++ + + F L + +S+TF H + V + +S D+ + +G D + + Sbjct: 509 TDQSRKVIPYSVANNFELAHTNSWTF------HTAKVACVSWSPDNVRLATGSLDNSVIV 562 Query: 162 WQPNFSMVKEI--DAAHTESIRDMAFSSNDSKFVTCSDDNILKIWN 205 W N I AH S + N++ V+ D+ +K WN Sbjct: 563 WNMNKPSDHPIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWN 608 >6CHG-A nrPDB Length = 312 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 44/188 (23%), Positives = 75/188 (39%), Gaps = 16/188 (8%) Query: 83 KFTHLSSNKVK----HVIPAIQ--WTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDS 136 + TH+ +++ H P I + +G L ++ W+ S T M AH Sbjct: 79 EITHIIYGRIRRLMGHTAPVISICYNNKGNILCSSSMDESIKEWHVLSGTALKTMSAHSD 138 Query: 137 AVTTMKY-SHDSDWMISGDADGMIKIWQPNFSMVKE--------IDAAHTESIRDMAFSS 187 AV ++ DS + SG DG+I+I+ + I I + FS Sbjct: 139 AVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWIAEDGVVPISTVKFSR 198 Query: 188 NDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKS-CDWHPEMGLIASASKDNLVKLW 246 N + S DN++K+W ++ G R H + K+ ++ + LI KD LV Sbjct: 199 NGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLKYNCGLELIYPQGKDPLVISG 258 Query: 247 DPRSGNCI 254 + C+ Sbjct: 259 NDSGSMCV 266 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 40/194 (20%), Positives = 86/194 (44%), Gaps = 27/194 (13%) Query: 82 SKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETL--MQAHDSAVT 139 SK L++ K I + W+P+ + +A+ S +F++ + + + + H + V Sbjct: 44 SKMMKLTTTH-KECINCLCWSPDSK--CIASGSEDFTV-EITHIIYGRIRRLMGHTAPVI 99 Query: 140 TMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTC-SDD 198 ++ Y++ + + S D IK W + +AH++++ + DS ++ S D Sbjct: 100 SICYNNKGNILCSSSMDESIKEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYD 159 Query: 199 NILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASA--------------SKDNLVK 244 +++I++ +G + L+ DW E G++ + S DN+VK Sbjct: 160 GLIRIFDTESGHCLKTLTYDK------DWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVK 213 Query: 245 LWDPRSGNCISSIL 258 LW+ G + + L Sbjct: 214 LWEYTRGTVVRTFL 227 Score = 37.7 bits (86), Expect = 0.010, Method: Compositional matrix adjust. Identities = 28/130 (21%), Positives = 61/130 (46%), Gaps = 1/130 (0%) Query: 161 IWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHW 220 +++ + S + ++ H E I + +S + + S+D ++I + G+ R++ GH Sbjct: 38 VYEISSSKMMKLTTTHKECINCLCWSPDSKCIASGSEDFTVEITHIIYGRIRRLM-GHTA 96 Query: 221 DVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAI 280 V S ++ + ++ S+S D +K W SG + ++ V+ ++L + Sbjct: 97 PVISICYNNKGNILCSSSMDESIKEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSG 156 Query: 281 SKDKSCRVFD 290 S D R+FD Sbjct: 157 SYDGLIRIFD 166 Score = 36.6 bits (83), Expect = 0.023, Method: Compositional matrix adjust. Identities = 40/203 (19%), Positives = 86/203 (42%), Gaps = 13/203 (6%) Query: 187 SNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW 246 S D + + + + ++ S+ K ++ + H + W P+ IAS S+D V++ Sbjct: 22 SPDGELIAICQNTDMLVYEISSSKMMKLTTTHKECINCLCWSPDSKCIASGSEDFTVEIT 81 Query: 247 DPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETD 306 G I ++ V+ + KGN+L + S D+S + + + S L + +D Sbjct: 82 HIIYGR-IRRLMGHTAPVISICYN-NKGNILCSSSMDESIKEWHV-LSGTALKTMSAHSD 138 Query: 307 -YMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKC-------ITSLSY 358 ++++ + S+ + YDG ++ FD + T+ Y D I+++ + Sbjct: 139 AVVSIDIPKFDSSILSSGSYDGLIRIFD--TESGHCLKTLTYDKDWIAEDGVVPISTVKF 196 Query: 359 NPVGHIFATAAKDRTIRFWTRAR 381 + G + D ++ W R Sbjct: 197 SRNGKFLLVKSLDNVVKLWEYTR 219 >4PSX-B nrPDB Length = 401 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 47/207 (22%), Positives = 84/207 (40%), Gaps = 19/207 (9%) Query: 190 SKFVTCSDDNILKIWNFSNG----KQERVLSGHHWDV-KSCDWHP-EMGLIASASKDNLV 243 + ++ SDD+ + +W +G K R + H D+ WH L + S+D+L+ Sbjct: 174 GRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLL 233 Query: 244 KLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRD 303 K+ D R+ N +K F NLL A D ++D+R + L + Sbjct: 234 KINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSG 293 Query: 304 ETDYM-TLEWHPINESMFTLACYDGSLKHFDLLQNLNE----------PILTIPYA-HDK 351 D + LE+ + + + D L +DL Q E P L + +A H Sbjct: 294 HEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRS 353 Query: 352 CITSLSYNP-VGHIFATAAKDRTIRFW 377 + NP + + A+A ++ ++ W Sbjct: 354 SVNDFDLNPQIPWLVASAEEENILQVW 380 >6E29-D nrPDB Length = 345 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 44/202 (21%), Positives = 80/202 (39%), Gaps = 23/202 (11%) Query: 54 VVEP-ETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVAT 112 + EP E Y + +P D P+ + KH+ AI +T G L+ T Sbjct: 138 ITEPVEVRYVLPSVPKRTSTETD-----PALREKQAKEDAKHMTTAIVYTASGDHLLAGT 192 Query: 113 YSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIW-QPNFSMV-- 169 G ++ +A + + +TT++ + ++ D +I+ + PN S Sbjct: 193 TKGRLNIIDARTREIIYSEKIASGIITTLRLTESGRELLVNAQDRIIRTFIVPNLSAADL 252 Query: 170 -----------KEIDAAHTESIRDMAFSSNDSKFVTCS--DDNILKIWNFSNGKQERVLS 216 K D + S +AFS+ ++V S +++ L IW +G R+L Sbjct: 253 DPDTIQLPLEHKFQDVVNRLSWNHVAFSAT-GEYVAASTYNNHELYIWERGHGSLVRMLE 311 Query: 217 GHHWDVKSCDWHPEMGLIASAS 238 G + +WHP L+A+ Sbjct: 312 GPKEEQGVIEWHPHRALLAACG 333 Score = 35.8 bits (81), Expect = 0.046, Method: Compositional matrix adjust. Identities = 16/75 (21%), Positives = 36/75 (48%) Query: 139 TTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDD 198 T ++++ D++ SG DG + IW V H+++I +++S ++ Sbjct: 29 TCVRFNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWSRCGRYLLSACQG 88 Query: 199 NILKIWNFSNGKQER 213 + +W+ +GK+ R Sbjct: 89 WKVILWDLQDGKRYR 103 Score = 33.9 bits (76), Expect = 0.15, Method: Compositional matrix adjust. Identities = 55/244 (22%), Positives = 86/244 (35%), Gaps = 30/244 (12%) Query: 172 IDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEM 231 I + H+ +R F+ + D + IW+ R L GH ++ S W Sbjct: 23 IRSGHSTCVR---FNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWSRCG 79 Query: 232 GLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQP-TKGNLLMAISKDKSCRV-- 288 + SA + V LWD + G + +F+ V P A+ +D+ V Sbjct: 80 RYLLSACQGWKVILWDLQDGKRYREV-RFRAPVYGAELHPWNHHQFAAALFEDQPMLVDI 138 Query: 289 ---FDIRYSMKEL-MCVRDETDYMTLEWHPINES--MFTLACYDGSLKHFDLLQNLNEPI 342 ++RY + + ETD E ++ M T Y S H LL + Sbjct: 139 TEPVEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGDH--LLAGTTKGR 196 Query: 343 LTIPYAHDK-----------CITSLSYNPVGHIFATAAKDRTIRFWT----RARPIDPNA 387 L I A + IT+L G A+DR IR + A +DP+ Sbjct: 197 LNIIDARTREIIYSEKIASGIITTLRLTESGRELLVNAQDRIIRTFIVPNLSAADLDPDT 256 Query: 388 YDDP 391 P Sbjct: 257 IQLP 260 >5TF2-A nrPDB Length = 407 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 22/79 (27%), Positives = 41/79 (51%), Gaps = 8/79 (10%) Query: 143 YSHDSDWMISGDADGMIKIWQ-PNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNIL 201 ++HD+ + +G DG +++W+ P+ V E AH I D+A D K VT D Sbjct: 180 FNHDNTLLATGGTDGYVRVWKVPSLEKVLEFK-AHEGEIEDLALGP-DGKLVTVGRDLKA 237 Query: 202 KIWNFSNGKQERVLSGHHW 220 +W +++++++ HW Sbjct: 238 SVW-----QKDQLVTQLHW 251 >4A11-B nrPDB Length = 408 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 32/149 (21%), Positives = 60/149 (40%), Gaps = 28/149 (18%) Query: 86 HLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSH 145 H+S KH + A V T + L + S + ++Q H + + +S Sbjct: 148 HMSPVSTKHCLVA-----------VGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSP 196 Query: 146 DSDWMI-SGDADGMIKIWQPNFS----------------MVKEIDAAHTESIRDMAFSSN 188 D+++ + AD +K+W + V+ + AH + + F+S+ Sbjct: 197 RYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSD 256 Query: 189 DSKFVTCSDDNILKIWNFSNGKQERVLSG 217 +T DN +++WN SNG+ V G Sbjct: 257 GLHLLTVGTDNRMRLWNSSNGENTLVNYG 285 Score = 41.2 bits (95), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 51/253 (20%), Positives = 97/253 (38%), Gaps = 62/253 (24%) Query: 149 WMISGDADGMIKIW------QPNFSMVKEIDA-------AHTESIRDMAFSSNDSK-FVT 194 +M+SG +DG+I ++ + ++ K + + H S+ + + +D+ F + Sbjct: 58 YMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTS 117 Query: 195 CSDDNILKIWNFSNGKQ-------ERVLSGHHWD---VKSCDWHPEMGLIASASKDNLVK 244 S D LK+W+ +N Q E + HH K C L+A ++ V+ Sbjct: 118 SSFDKTLKVWD-TNTLQTADVFNFEETVYSHHMSPVSTKHC-------LVAVGTRGPKVQ 169 Query: 245 LWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDE 304 L D +SG+C + + +L + P +L S D +++D+R R Sbjct: 170 LCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR---------RAS 220 Query: 305 TDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHI 364 +TL+ H +S + + + AH+ + L + G Sbjct: 221 GCLITLDQHNGKKS---------------------QAVESANTAHNGKVNGLCFTSDGLH 259 Query: 365 FATAAKDRTIRFW 377 T D +R W Sbjct: 260 LLTVGTDNRMRLW 272 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 19/78 (24%), Positives = 38/78 (48%), Gaps = 13/78 (16%) Query: 269 FQPTKGNLLMAISKDKSCRVFDIR-------YSMKELMCV-RDETDYM-----TLEWHPI 315 +P +G +++ D ++D+ Y+ K + + RD D T++W+P Sbjct: 51 IEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPH 110 Query: 316 NESMFTLACYDGSLKHFD 333 + MFT + +D +LK +D Sbjct: 111 DTGMFTSSSFDKTLKVWD 128 >5Y1U-A nrPDB Length = 456 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 32/118 (27%), Positives = 54/118 (45%), Gaps = 10/118 (8%) Query: 269 FQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMT-------LEWHPINESMFT 321 + P L++ S D + ++DI KE V +T + + WH ++ES+F Sbjct: 216 WNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFG 275 Query: 322 LACYDGSLKHFDLLQ-NLNEPILTIPYAHDKCITSLSYNPVGH-IFATAAKDRTIRFW 377 D L +D N ++P ++ AH + LS+NP I AT + D+T+ W Sbjct: 276 SVADDQKLMIWDTRSNNTSKPSHSVD-AHTAEVNCLSFNPYSEFILATGSADKTVALW 332 Score = 35.8 bits (81), Expect = 0.039, Method: Compositional matrix adjust. Identities = 29/134 (21%), Positives = 62/134 (46%), Gaps = 18/134 (13%) Query: 131 MQAHDSAVTTMKYSHDSDWMIS-GDADGMIKIWQ-PNFSMVKEIDAAHTESIRDMAFS-S 187 + AH + V + ++ S+++++ G AD + +W N + +H + I + +S Sbjct: 300 VDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPH 359 Query: 188 NDSKFVTCSDDNILKIWNFSNGKQER--------------VLSGHHWDVKSCDWHP-EMG 232 N++ + D L +W+ S +E+ + GH + W+P E Sbjct: 360 NETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPW 419 Query: 233 LIASASKDNLVKLW 246 +I S S+DN++++W Sbjct: 420 VICSVSEDNIMQVW 433 >1PI6-A nrPDB Length = 615 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 64/300 (21%), Positives = 108/300 (36%), Gaps = 71/300 (23%) Query: 78 INLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYS----GEFSLWNASSFTFETLMQA 133 +N+ S+F L+ I I W EGRRL V G F W++ + E + Sbjct: 106 VNVKSEFQVLAGP-----ISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHS 160 Query: 134 HDSAVTTMKYSHDSDWMISGDADGMIKIWQ-PNFSMVKEIDAAHTES--IRDMAFSSNDS 190 +K S M GD DG + +Q P F H + +RD+ FS + Sbjct: 161 QRINACHLKQSRPMRSMTVGD-DGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSG 219 Query: 191 KFV---------TCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDN 241 +FV +C D + + QE V G + + W A+ D Sbjct: 220 EFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGG----IFALSWLDSQKF-ATVGADA 274 Query: 242 LVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCV 301 +++WD + C+ K T+ K + GN + + + R+ + Sbjct: 275 TIRVWDVTTSKCVQ-----KWTLDKQQL----GNQQVGVVATGNGRIISL---------- 315 Query: 302 RDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPV 361 DG+L ++L ++ +L H+K IT+L+ NP+ Sbjct: 316 ----------------------SLDGTLNFYELG---HDEVLKTISGHNKGITALTVNPL 350 Score = 30.4 bits (67), Expect = 1.9, Method: Compositional matrix adjust. Identities = 57/280 (20%), Positives = 102/280 (36%), Gaps = 57/280 (20%) Query: 136 SAVTTMKYS--HDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFV 193 S VTT+K+S S ++ SGD G + +W F KE ++ Sbjct: 65 SVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFD--KESNSVEV---------------- 106 Query: 194 TCSDDNILKIWNFSNGKQE-RVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGN 252 N K E +VL+G D+ S D+ + +DN SGN Sbjct: 107 --------------NVKSEFQVLAGPISDI-SWDFEGRRLCVVGEGRDNFGVFISWDSGN 151 Query: 253 CISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFD---IRYSMKELMCVRDETDYMT 309 + + + + ++ M + D S + ++S + + + Sbjct: 152 SLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRD 211 Query: 310 LEWHP-INESMFT------LACYDGSLKHF-DLLQNLNEPILTIPYAHDKCITSLSYNPV 361 +E+ P E + T ++C+DG F +++ EP+ I +LS+ Sbjct: 212 VEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPV-------QGGIFALSWLD- 263 Query: 362 GHIFATAAKDRTIRFW--TRARPIDPNAYDDPTYNNKKIN 399 FAT D TIR W T ++ + D N+++ Sbjct: 264 SQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVG 303 >5K19-A nrPDB Length = 569 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 36/162 (22%), Positives = 63/162 (38%), Gaps = 29/162 (17%) Query: 93 KHVIPAIQWTPEGRRL-VVATYSGEFSLWNASSFT------FETLMQAHDSAVTTMKYSH 145 K + ++W P L +VA SG L+N ++ L Q AV T K Sbjct: 149 KSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKS 208 Query: 146 DSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTC-SDDNILKIW 204 + ++ W ++ + AFS D KF+ C S D L+++ Sbjct: 209 TRNPLLK---------W-----------TVGEGALNEFAFSP-DGKFLACVSQDGFLRVF 247 Query: 205 NFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW 246 NF + + + + + W P+ I + +D+LV +W Sbjct: 248 NFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVW 289 >3C9C-A nrPDB Length = 432 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 41/166 (24%), Positives = 64/166 (38%), Gaps = 40/166 (24%) Query: 215 LSGHHWDVKSCDWHPEM-GLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTK 273 L GH + W+P + G + SAS D+ + LWD Sbjct: 179 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDIN------------------------ 214 Query: 274 GNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFD 333 + K RV D + V ++ + WH ++ES+F D L +D Sbjct: 215 -------ATPKEHRVIDAKNIFTGHTAVVED-----VAWHLLHESLFGSVADDQKLMIWD 262 Query: 334 LL-QNLNEPILTIPYAHDKCITSLSYNPVGH-IFATAAKDRTIRFW 377 N ++P T+ AH + LS+NP I AT + D+T+ W Sbjct: 263 TRNNNTSKPSHTVD-AHTAEVNCLSFNPYSEFILATGSADKTVALW 307 Score = 36.6 bits (83), Expect = 0.024, Method: Compositional matrix adjust. Identities = 51/250 (20%), Positives = 104/250 (41%), Gaps = 38/250 (15%) Query: 20 QPPLKKYVTQRRSVDVS-SPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVI 78 QP L+ Q+ +S +P +N Y ++ +TI + NA RVI Sbjct: 174 QPDLRLRGHQKEGYGLSWNPNLNGY----------LLSASDDHTICLWDINATPKEHRVI 223 Query: 79 NLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGE-FSLW---NASSFTFETLMQAH 134 + + FT ++ V+ + W L + + +W N ++ + AH Sbjct: 224 DAKNIFTGHTA-----VVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAH 278 Query: 135 DSAVTTMKYSHDSDWMIS-GDADGMIKIWQ-PNFSMVKEIDAAHTESIRDMAFS-SNDSK 191 + V + ++ S+++++ G AD + +W N + +H + I + +S N++ Sbjct: 279 TAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETI 338 Query: 192 FVTCSDDNILKIWNFSNGKQER--------------VLSGHHWDVKSCDWHP-EMGLIAS 236 + D L +W+ S +E+ + GH + W+P E +I S Sbjct: 339 LASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICS 398 Query: 237 ASKDNLVKLW 246 S+DN++++W Sbjct: 399 VSEDNIMQVW 408 >5BJS-A nrPDB Length = 605 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 28/103 (27%), Positives = 49/103 (47%), Gaps = 8/103 (7%) Query: 151 ISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFS-SNDSKFVTCSDDNILKIWNFS-- 207 I+G+ +G +K++ + H I D+A S +N + SDD ++IW+ + Sbjct: 153 IAGN-EGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIWSLAPE 211 Query: 208 NGKQERVL----SGHHWDVKSCDWHPEMGLIASASKDNLVKLW 246 + KQ V GH +D+ S +H + SA D ++ LW Sbjct: 212 HEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLW 254 >4XFV-A nrPDB Length = 792 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 42/183 (22%), Positives = 78/183 (42%), Gaps = 22/183 (12%) Query: 131 MQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ-PNFSMVKEIDAAHTESIRDMAFSSND 189 ++ H++ VT +++ DSD+M+S D +KIW+ ++S ++ I S +A S+ Sbjct: 59 LKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP 118 Query: 190 SKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPE-MGLIASASKDNLVKLWDP 248 S D + IW N + + H + +K ++P + L K L+ + Sbjct: 119 SLISVGCADGTISIWR-QNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGT 177 Query: 249 RSGNCISSILKFKHTVLKTRF------------------QPTKGN-LLMAISKDKSCRVF 289 I+S + + K R Q T G+ LL + S+D+ R++ Sbjct: 178 NVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW 237 Query: 290 DIR 292 IR Sbjct: 238 RIR 240 Score = 36.2 bits (82), Expect = 0.033, Method: Compositional matrix adjust. Identities = 39/163 (23%), Positives = 71/163 (43%), Gaps = 23/163 (14%) Query: 127 FETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFS 186 FE L+ HD ++++++ +++ AD + +W+P+ E S+R S Sbjct: 277 FEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPD-----ETSGIWVCSLRLGEMS 331 Query: 187 SNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW 246 S + T S F++ + + L+ + K+ W A+KDN++ Sbjct: 332 SKGASTATGSSGGFWSCLWFTHERMDFFLT----NGKTGSWR------MWATKDNIIC-- 379 Query: 247 DPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVF 289 D R G IS K V + P+ G L+A S D++ R+F Sbjct: 380 DQRLG--ISGATK---DVTDIAWSPS-GEYLLATSLDQTTRLF 416 Score = 32.3 bits (72), Expect = 0.42, Method: Compositional matrix adjust. Identities = 43/210 (20%), Positives = 86/210 (40%), Gaps = 55/210 (26%) Query: 215 LSGHHWDVKSCDWHPEMGLIASASKDN-----LVKLWDPRSGNCISSILKFKHTVLKTRF 269 L GH +++ D P+ LIASA + N +++++ + I L F H++ TR Sbjct: 558 LYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPF-HSLTITRL 616 Query: 270 QPTK-GNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGS 328 + +K G L+++ +D+ +++ R+ D Sbjct: 617 KFSKDGKFLLSVCRDRKWALWE-----------RNMED---------------------- 643 Query: 329 LKHFDLLQNLNEPILTIPYAHDKCITSLSYNPV--GHIFATAAKDRTIRFWTRAR-PIDP 385 F+L +P H + I + P+ G++F TA++D+T++ W + P D Sbjct: 644 -NTFELRFKNEKP-------HTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADD 695 Query: 386 NAYDDPTYNNKKINGWFFGINNDINAVREK 415 + + K + I+ + +REK Sbjct: 696 YVLEASIKHTKAVT----AISIHDSMIREK 721 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 21/78 (26%), Positives = 38/78 (48%), Gaps = 7/78 (8%) Query: 134 HDSAVTTMKYSHDSDWMISGDADGMIKIWQPN-----FSMVKEIDAAHTESIRDMAFSSN 188 H +T +K+S D +++S D +W+ N F + + + HT I D ++ Sbjct: 609 HSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPL 668 Query: 189 D--SKFVTCSDDNILKIW 204 + + FVT S D +K+W Sbjct: 669 EFGNVFVTASRDKTVKVW 686 >6BX3-B nrPDB Length = 412 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 22/79 (27%), Positives = 45/79 (56%), Gaps = 6/79 (7%) Query: 310 LEWHPINESMFTLACYDGSLKHFDLLQNLNEPILT---IPYAHDKCITSLSYNPVGHIFA 366 L++ P + + L C +G+L +D+ + PI + AH + ITS++++P G + Sbjct: 31 LQFSPCGDYL-ALGCANGALVIYDM--DTFRPICVPGNMLGAHVRPITSIAWSPDGRLLL 87 Query: 367 TAAKDRTIRFWTRARPIDP 385 T+++D +I+ W ++P P Sbjct: 88 TSSRDWSIKLWDLSKPSKP 106 >4XYI-A nrPDB Length = 430 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 35/168 (20%), Positives = 70/168 (41%), Gaps = 16/168 (9%) Query: 232 GLIASASKDNLVKLWD---PRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRV 288 L+ S S D +++ D P S + + + V F P LL S D + + Sbjct: 249 ALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVAL 308 Query: 289 FDIRYSMKELMCVRDETDYM-TLEWHPINESMFTLACYDGSLKHFDLLQNLNE------- 340 +D+R + L + D + ++W P +E + + D + +DL + E Sbjct: 309 WDLRRLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSE 368 Query: 341 ----PILTIPYAHDKCITSLSYNPVGH-IFATAAKDRTIRFWTRARPI 383 ++ + H ++ LS+NP + A+ A D ++ W+ ++ I Sbjct: 369 DGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWSPSKVI 416 Score = 35.0 bits (79), Expect = 0.063, Method: Compositional matrix adjust. Identities = 30/144 (20%), Positives = 65/144 (45%), Gaps = 18/144 (12%) Query: 123 SSFTFETLMQAHDSAVTTMKYSHDSDWMIS-GDADGMIKIWQ-PNFSMVKEIDAAHTESI 180 SS + ++AH+ V + ++ +D++++ AD + +W + H + + Sbjct: 269 SSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLNQRLHTLEGHEDEV 328 Query: 181 RDMAFSSNDSK-FVTCSDDNILKIWNFSNGKQERVL--------------SGHHWDVKSC 225 ++ +S +D VT S D + +W+ S +E+ + GH V Sbjct: 329 YNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDL 388 Query: 226 DWHPEMG-LIASASKDNLVKLWDP 248 W+P ++AS + DN++++W P Sbjct: 389 SWNPNNKWVLASLADDNILQIWSP 412 >3JZG-A nrPDB Length = 402 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 20/73 (27%), Positives = 40/73 (54%), Gaps = 3/73 (4%) Query: 220 WDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMA 279 W S HP L+A A ++++ +P + CI + + + + +F P NLL++ Sbjct: 113 WTYDSNTSHP---LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLS 169 Query: 280 ISKDKSCRVFDIR 292 +SKD + R+++I+ Sbjct: 170 VSKDHALRLWNIQ 182 Score = 37.7 bits (86), Expect = 0.011, Method: Compositional matrix adjust. Identities = 41/170 (24%), Positives = 74/170 (43%), Gaps = 14/170 (8%) Query: 102 TPEGRRLVVATY-SGEFSLWNASSFTFETLMQAH-----DSAVTTMKYSHDSD----WMI 151 + EG LV AT S +L+ S L+Q++ D T +++DS+ + Sbjct: 66 SKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLA 125 Query: 152 SGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSND-SKFVTCSDDNILKIWNFSNGK 210 + G+I+I P + H +I ++ F D + ++ S D+ L++WN Sbjct: 126 VAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDT 185 Query: 211 QERV---LSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSI 257 + + GH +V S D+ I S D+ +KLW S +++I Sbjct: 186 LVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAI 235 >3EI3-B nrPDB Length = 383 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 51/225 (22%), Positives = 85/225 (37%), Gaps = 21/225 (9%) Query: 222 VKSCDWHPEM-GLIASASKDNLVKLWDPRSGNCISSILKFK--HTVLKTRFQPTKGNLLM 278 V S +WHP +A SK + LWD N S I + +F N L Sbjct: 76 VTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDAITGMKFNQFNTNQLF 135 Query: 279 AISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWH---PINESMFTLACYDGSLKHFDLL 335 S + + D S+ ++ D DY W+ ++ S LA D + + L Sbjct: 136 VSSIRGATTLRDFSGSVIQVFAKTDSWDY----WYCCVDVSVSRQMLATGDSTGRLLLLG 191 Query: 336 QNLNEPILTIPYAHDKCITSLSYNP-VGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYN 394 + +E + H +T +NP + AT++ D T++ W D N+Y + Sbjct: 192 LDGHE--IFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMPH 249 Query: 395 NKKINGWFFG--------INNDINAVREKSEFGAAPPPPATLEPH 431 K +N +F + N +R S + + P + PH Sbjct: 250 EKPVNAAYFNPTDSTKLLTTDQRNEIRVYSSYDWSKPDQIIIHPH 294 >3DWL-C nrPDB Length = 377 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 35/157 (22%), Positives = 63/157 (40%), Gaps = 17/157 (10%) Query: 182 DMAFSSNDSKFVTCSDDNILKIWNF-SNG-KQERVLSGHHWDVKSCDWHPEMGLIASASK 239 + AF+S ++FVT + N ++++ NG K R S H V DW P+ I + S+ Sbjct: 16 EHAFNSQRTEFVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSNRIVTCSQ 75 Query: 240 DNLVKLWDPRSGNCISS---ILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMK 296 D +++ R +L+ R+ P + + RV + Y + Sbjct: 76 DRNAYVYEKRPDGTWKQTLVLLRLNRAATFVRWSPNEDKFAVG----SGARVISVCYFEQ 131 Query: 297 E-------LMCVRDETDYMTLEWHPINESMFTLACYD 326 E + + ++L+WHP N + C D Sbjct: 132 ENDWWVSKHLKRPLRSTILSLDWHP-NNVLLAAGCAD 167 >4J0X-A nrPDB Length = 451 Score = 38.1 bits (87), Expect = 0.009, Method: Compositional matrix adjust. Identities = 29/127 (22%), Positives = 54/127 (42%), Gaps = 4/127 (3%) Query: 123 SSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ-PNFSMVKEIDAAHTES-I 180 S +E + H + T+ S D ++++G D + +W + S VK I + Sbjct: 102 SKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEV 161 Query: 181 RDMAFSSN-DSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASK 239 +AF N D + +C+D I + ++ + Q +L GHH V+ + ++ Sbjct: 162 LSLAFRKNSDQLYASCADFKI-RTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGAR 220 Query: 240 DNLVKLW 246 D LW Sbjct: 221 DRTAMLW 227 >5A31-R nrPDB Length = 386 Score = 38.1 bits (87), Expect = 0.009, Method: Compositional matrix adjust. Identities = 52/252 (20%), Positives = 101/252 (40%), Gaps = 33/252 (13%) Query: 98 AIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADG 157 ++ W G L V +G +++ + H V + +++ + SG D Sbjct: 136 SLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWNNHV--LTSGSRDH 193 Query: 158 MI-----KIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQE 212 I ++ P F ++ +HT+ + + ++ D+K + +DN++ ++ ++ Sbjct: 194 RILHRDVRMPDPFFETIE----SHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPI 249 Query: 213 RVLSGHHWDVKSCDWHP-EMGLIAS--ASKDNLVKLW---------DPRSGNCISSILKF 260 H VK+ W P + G++A+ + D +K+W D SG+ I +++ Sbjct: 250 LTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWS 309 Query: 261 KHT-VLKTRFQPTKGNLLM---------AISKDKSCRVFDIRYSMKELMCVRDETDYMTL 310 K+T L T +K NL + AI K S RV + S V D Sbjct: 310 KNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLR 369 Query: 311 EWHPINESMFTL 322 W + S+ L Sbjct: 370 YWKLFDVSVLNL 381 Score = 31.6 bits (70), Expect = 0.79, Method: Compositional matrix adjust. Identities = 35/166 (21%), Positives = 70/166 (42%), Gaps = 7/166 (4%) Query: 215 LSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKG 274 + H +V W+ +AS DN+V +++ S + I + + K V + P K Sbjct: 210 IESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKR 269 Query: 275 NLLM--AISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDG-SLKH 331 +L + D+ +++++ S+K + + + + W + T Y +L Sbjct: 270 GVLATGGGTADRRLKIWNVNTSIK-MSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTL 328 Query: 332 FDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 +D N +PI I H + L+ + G + A D T+R+W Sbjct: 329 WDC--NSMDPI-AILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYW 371 >5WLC-SG nrPDB Length = 573 Score = 37.7 bits (86), Expect = 0.010, Method: Compositional matrix adjust. Identities = 29/127 (22%), Positives = 54/127 (42%), Gaps = 4/127 (3%) Query: 123 SSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ-PNFSMVKEIDAAHTES-I 180 S +E + H + T+ S D ++++G D + +W + S VK I + Sbjct: 224 SKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEV 283 Query: 181 RDMAFSSN-DSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASK 239 +AF N D + +C+D I + ++ + Q +L GHH V+ + ++ Sbjct: 284 LSLAFRKNSDQLYASCADFKI-RTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGAR 342 Query: 240 DNLVKLW 246 D LW Sbjct: 343 DRTAMLW 349 >5A9Q-2 nrPDB Length = 326 Score = 37.7 bits (86), Expect = 0.012, Method: Compositional matrix adjust. Identities = 41/177 (23%), Positives = 68/177 (38%), Gaps = 20/177 (11%) Query: 175 AHTESIRDMAFSSNDSK-FVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGL 233 HT+ I + F + + + SDD+ +IWN G Q H + C WHPE Sbjct: 122 GHTDFINGLVFDPKEGQEIASVSDDHTCRIWNL-EGVQTAHFVLHSPGMSVC-WHPEETF 179 Query: 234 -IASASKDNLVKLWDPRSGNCISSI------LKFKHTVLKTRFQ--PTKGNLLMAISKDK 284 + A K+ ++ +D + I S+ L H LK F+ GN + + Sbjct: 180 KLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWLIWDITR 239 Query: 285 SCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEP 341 S + R + C+ W I+E++F Y G + + +L P Sbjct: 240 SSYPQNKRPVHMDRACL--------FRWSTISENLFATTGYPGKMASQFQIHHLGHP 288 >3W15-A nrPDB Length = 368 Score = 37.4 bits (85), Expect = 0.013, Method: Compositional matrix adjust. Identities = 50/254 (19%), Positives = 104/254 (40%), Gaps = 47/254 (18%) Query: 169 VKEIDAAHTE-SIRDMAFS-SNDSKFVTCSDDNILKIWNFSNGKQE---RVLSGHHWDVK 223 + E+++ T+ + D+A++ S++++ + D L++ F +E + H +V Sbjct: 53 IVEVNSFLTQDCLFDLAWNESHENQVLVAQGDGTLRL--FDTTFKEFPIAIFKEHEREVF 110 Query: 224 SCDWH-PEMGLIASASKDNLVKLWDPRSGNCI---------------------------S 255 SC+W+ S+S D +K+W P + + Sbjct: 111 SCNWNLVNRQNFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFT 170 Query: 256 SILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRY---SMKELMCVRDETDYMTLEW 312 I K ++ V + +F P NL+++ S + +FDIR + V + +T ++ Sbjct: 171 GISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDF 230 Query: 313 HPINESMFTLACYDGSLKHFDLLQNLNEP--------ILTIPYAHDKCITSLSYNP-VGH 363 + + D +++ +D+ P I IP AH I ++++P + Sbjct: 231 NKYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSN 290 Query: 364 IFATAAKDRTIRFW 377 I +A+ D T R W Sbjct: 291 ILMSASYDMTCRIW 304 Score = 32.7 bits (73), Expect = 0.36, Method: Compositional matrix adjust. Identities = 26/106 (24%), Positives = 52/106 (49%), Gaps = 10/106 (9%) Query: 277 LMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQ 336 L + D+S R+ ++ + + C+ D L W+ +E+ +A DG+L+ FD Sbjct: 42 LFILEIDRSGRIVEVNSFLTQ-DCLFD------LAWNESHENQVLVAQGDGTLRLFD--T 92 Query: 337 NLNEPILTIPYAHDKCITSLSYNPVGHI-FATAAKDRTIRFWTRAR 381 E + I H++ + S ++N V F +++ D +I+ W+ R Sbjct: 93 TFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLR 138 >5WLC-LH nrPDB Length = 896 Score = 36.2 bits (82), Expect = 0.030, Method: Compositional matrix adjust. Identities = 16/59 (27%), Positives = 34/59 (57%), Gaps = 1/59 (1%) Query: 105 GRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ 163 G++L V SG S+ + + L++ H +V ++ +SHD +++SG + ++ +WQ Sbjct: 268 GQQLAVGFASGVISIVSLADLQIR-LLKWHIDSVLSLSFSHDGSYLLSGGWEKVMSLWQ 325 >5CXB-B nrPDB Length = 369 Score = 35.4 bits (80), Expect = 0.056, Method: Compositional matrix adjust. Identities = 19/72 (26%), Positives = 35/72 (48%), Gaps = 1/72 (1%) Query: 211 QERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSI-LKFKHTVLKTRF 269 Q+ + GH V+S P +A+ D V++W+ +G + S+ L V R+ Sbjct: 13 QQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNTVRW 72 Query: 270 QPTKGNLLMAIS 281 +PTK ++A + Sbjct: 73 RPTKDTFILAAA 84 Score = 35.0 bits (79), Expect = 0.071, Method: Compositional matrix adjust. Identities = 27/85 (31%), Positives = 36/85 (42%), Gaps = 14/85 (16%) Query: 176 HTESIRDMAFSSND-SKFVTCSDDNILKIWN--FSNGKQE-------RVLSGHH----WD 221 HTE+IR + F F SDD L+I++ N + E ++L GH Sbjct: 284 HTEAIRAVRFHKGGLPLFADASDDGSLQIFHGKVPNDQLENPTIVPVKMLKGHKVVNKLG 343 Query: 222 VKSCDWHPEMGLIASASKDNLVKLW 246 V DWHP SA D +LW Sbjct: 344 VLDIDWHPREPWCVSAGADGTARLW 368 >4BH6-A nrPDB Length = 308 Score = 35.0 bits (79), Expect = 0.060, Method: Compositional matrix adjust. Identities = 50/242 (20%), Positives = 97/242 (40%), Gaps = 33/242 (13%) Query: 98 AIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADG 157 ++ W G L V +G +++ + H V + +++ + SG D Sbjct: 67 SLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWNNHV--LTSGSRDH 124 Query: 158 MI-----KIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQE 212 I ++ P F ++ +HT+ + + ++ D+K + +DN++ ++ ++ Sbjct: 125 RILHRDVRMPDPFFETIE----SHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPI 180 Query: 213 RVLSGHHWDVKSCDWHP-EMGLIAS--ASKDNLVKLW---------DPRSGNCISSILKF 260 H VK+ W P + G++A+ + D +K+W D SG+ I +++ Sbjct: 181 LTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWS 240 Query: 261 KHT-VLKTRFQPTKGNLLM---------AISKDKSCRVFDIRYSMKELMCVRDETDYMTL 310 K+T L T +K NL + AI K S RV + S V D Sbjct: 241 KNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLR 300 Query: 311 EW 312 W Sbjct: 301 YW 302 Score = 33.9 bits (76), Expect = 0.15, Method: Compositional matrix adjust. Identities = 38/181 (20%), Positives = 73/181 (40%), Gaps = 7/181 (3%) Query: 71 YRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETL 130 +R R + +P F + + V ++W +L ++ +S + Sbjct: 124 HRILHRDVRMPDPFFETIESHTQEVC-GLKWNVADNKLASGGNDNVVHVYEGTSKSPILT 182 Query: 131 MQAHDSAVTTMKYSHDSDWMIS---GDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSS 187 H +AV M +S +++ G AD +KIW N S +K D I +M +S Sbjct: 183 FDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTS-IKMSDIDSGSQICNMVWSK 241 Query: 188 NDSKFVTCSDDNI--LKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKL 245 N ++ VT + L +W+ ++ +L GH + V + + S + D ++ Sbjct: 242 NTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRY 301 Query: 246 W 246 W Sbjct: 302 W 302 Score = 31.2 bits (69), Expect = 1.0, Method: Compositional matrix adjust. Identities = 35/166 (21%), Positives = 70/166 (42%), Gaps = 7/166 (4%) Query: 215 LSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKG 274 + H +V W+ +AS DN+V +++ S + I + + K V + P K Sbjct: 141 IESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKR 200 Query: 275 NLLM--AISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDG-SLKH 331 +L + D+ +++++ S+K + + + + W + T Y +L Sbjct: 201 GVLATGGGTADRRLKIWNVNTSIK-MSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTL 259 Query: 332 FDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 +D N +PI I H + L+ + G + A D T+R+W Sbjct: 260 WDC--NSMDPI-AILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYW 302 >5YZG-2 nrPDB Length = 646 Score = 34.7 bits (78), Expect = 0.099, Method: Compositional matrix adjust. Identities = 38/172 (22%), Positives = 71/172 (41%), Gaps = 21/172 (12%) Query: 219 HWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKH--TVLKTRFQPTKGNL 276 H DV + + I +AS D VK W + I + F+ V+++ ++G L Sbjct: 89 HRDVITHVVCTKTDFIITASHDGHVKFWK-KIEEGIEFVKHFRSHLGVIESIAVSSEGAL 147 Query: 277 LMAISKDKSCRVFDI----RYSMKELMCVRDETDYMTLEWHPIN------ESMFTLACYD 326 ++ DK+ +VFD+ +M +L + +++ I+ +S + YD Sbjct: 148 FCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYCPGDAISSVAASEKSTGKIFIYD 207 Query: 327 GSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWT 378 G + N+P+ H +T + NPV ++ K I +WT Sbjct: 208 G--------RGDNQPLHIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWT 251 >4E5Z-B nrPDB Length = 436 Score = 33.9 bits (76), Expect = 0.14, Method: Compositional matrix adjust. Identities = 41/195 (21%), Positives = 82/195 (42%), Gaps = 19/195 (9%) Query: 108 LVVATYSGEFSLWNASSFTFETLMQA--HDSAVTTMKYS-HDSDWMISGDADGMIKIWQP 164 + V + G+ LWN T ++ ++T +K++ +++ + +G ++ Sbjct: 135 VAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDF 194 Query: 165 NFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFS-NGKQERVLSGHHWDVK 223 ++++ ++ T +I + + S + + DN+ + + +GK+ L H V Sbjct: 195 KGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVT 254 Query: 224 ------SCDWHPEMGLIASASKDNLVKLWDPRSGNCISSI---LKFKHTVLKTRFQPTKG 274 CDW +A+AS D VK+WD R +S L +H V F P G Sbjct: 255 HVALNPCCDW-----FLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSP-DG 308 Query: 275 NLLMAISKDKSCRVF 289 L+ + RV+ Sbjct: 309 ARLLTTDQKSEIRVY 323 >5AJA-A nrPDB Length = 361 Score = 33.1 bits (74), Expect = 0.25, Method: Compositional matrix adjust. Identities = 41/196 (20%), Positives = 77/196 (39%), Gaps = 42/196 (21%) Query: 89 SNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSD 148 +N+ + ++ R L++ T +G+ L+N S E H+SA+T ++ S D Sbjct: 33 ANEDESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGS 92 Query: 149 WMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSN 208 +++ W S + + +S+ DM S + +V FS Sbjct: 93 LLLTS------ATWSQPLSALWGM-----KSVFDMKHSFTEDHYV-----------EFSK 130 Query: 209 GKQERVLS-----GHHWDVKSCD-----WHPEMG------LIASASKDNLV----KLWDP 248 Q+RV+ H +D+++ + ++P++ D+LV LWD Sbjct: 131 HSQDRVIGTKGDIAHIYDIQTGNKLLTLFNPDLANNYKRNCATFNPTDDLVLNDGVLWDV 190 Query: 249 RSGNCISSILKFKHTV 264 RS I KF + Sbjct: 191 RSAQAIHKFDKFNMNI 206 >5MC6-j nrPDB Length = 397 Score = 32.7 bits (73), Expect = 0.31, Method: Compositional matrix adjust. Identities = 24/79 (30%), Positives = 32/79 (40%), Gaps = 14/79 (17%) Query: 347 YAHDKCITSLSYNPVGHIFATAAKDRTIRFW---TRARPIDPNAYDDPTYNNKKINGWFF 403 +AH + SLS+N G +A D +RFW T+ R N + D Sbjct: 288 FAHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERITTLNMHCDDIE---------- 337 Query: 404 GINNDINAVREKSEFGAAP 422 I DI AV E + A P Sbjct: 338 -IEEDILAVDEHGDSLAEP 355 >5WLC-LV nrPDB Length = 707 Score = 32.0 bits (71), Expect = 0.63, Method: Compositional matrix adjust. Identities = 11/26 (42%), Positives = 20/26 (76%) Query: 232 GLIASASKDNLVKLWDPRSGNCISSI 257 GL+A+ ++ N+V+ WDPRS + +S + Sbjct: 193 GLLAAGTETNVVEFWDPRSRSRVSKL 218 >4NOX-A nrPDB Length = 746 Score = 32.0 bits (71), Expect = 0.65, Method: Compositional matrix adjust. Identities = 21/88 (23%), Positives = 35/88 (39%), Gaps = 5/88 (5%) Query: 191 KFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRS 250 +FV D + WN + E ++ HW W P +G ++ V+LW Sbjct: 170 QFVMYRGDTVGVFWNNEKDQPENIVDRQHWTETFVQWSP-LGTYLTSVHAQGVQLW---G 225 Query: 251 GNCISSILKFKHTVLK-TRFQPTKGNLL 277 G S + +F H + F P + L+ Sbjct: 226 GASWSRLRRFPHPFVNLVAFSPGEKYLV 253 >6CHG-D nrPDB Length = 439 Score = 31.2 bits (69), Expect = 0.94, Method: Compositional matrix adjust. Identities = 22/86 (25%), Positives = 38/86 (44%), Gaps = 6/86 (6%) Query: 81 PSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSF----TFETLMQAHDS 136 P K TH V V ++++P G L V +G +++ S T AH Sbjct: 17 PEKLTHTLEVPVAAV--CVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTR 74 Query: 137 AVTTMKYSHDSDWMISGDADGMIKIW 162 +V ++ +S+D ++ S D K+W Sbjct: 75 SVQSVCWSNDGRYLWSSGRDWYAKLW 100 Score = 29.6 bits (65), Expect = 3.2, Method: Compositional matrix adjust. Identities = 17/76 (22%), Positives = 37/76 (48%), Gaps = 4/76 (5%) Query: 137 AVTTMKYSHDSDWMISGDADGMIKIWQPN----FSMVKEIDAAHTESIRDMAFSSNDSKF 192 A +K+S D++ G ++G I I+ + +M+ AHT S++ + +S++ Sbjct: 29 AAVCVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSVQSVCWSNDGRYL 88 Query: 193 VTCSDDNILKIWNFSN 208 + D K+W+ + Sbjct: 89 WSSGRDWYAKLWDMTQ 104 >3JB9-S nrPDB Length = 488 Score = 30.4 bits (67), Expect = 1.9, Method: Compositional matrix adjust. Identities = 19/72 (26%), Positives = 32/72 (44%), Gaps = 1/72 (1%) Query: 92 VKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWM- 150 V I ++ P+G V +GE + SS T H S V T+++ + W+ Sbjct: 332 VAQHITSLAVHPDGNLFVAGLENGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWLV 391 Query: 151 ISGDADGMIKIW 162 ++ + D I IW Sbjct: 392 VTTNDDSDIFIW 403 >5WLC-LN nrPDB Length = 776 Score = 30.0 bits (66), Expect = 2.0, Method: Compositional matrix adjust. Identities = 35/160 (21%), Positives = 62/160 (38%), Gaps = 15/160 (9%) Query: 95 VIPAIQWTPEGRRLVVATYSGEFSLWNASS----FTFETLMQAHDSAVTTMKYSHDSDWM 150 VI +I +L V +G L + S +T++ ++ V T+ + D D++ Sbjct: 143 VIWSISINDSQDKLSVGCDNGTVVLIDISGGPGVLEHDTILMRQEARVLTLAWKKD-DFV 201 Query: 151 ISGDADGMIKIW--QPN------FSMVKEIDAAHTES--IRDMAFSSNDSKFVTCSDDNI 200 I G +DG I+IW Q N ++D A ES + + + + + Sbjct: 202 IGGCSDGRIRIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDSTGS 261 Query: 201 LKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKD 240 +K W+F + H DV + + SA D Sbjct: 262 IKFWDFQFATLNQSFKAHDADVLCLTTDTDNNYVFSAGVD 301 >1QGS-A nrPDB Length = 255 Score = 30.0 bits (66), Expect = 2.1, Method: Compositional matrix adjust. Identities = 24/86 (27%), Positives = 41/86 (47%), Gaps = 14/86 (16%) Query: 156 DGMIKIWQPNFSMVKE-IDAAHTESIRDMAFSSNDSKFVT-CSDDNILKIWNFSNGKQER 213 D ++ +Q + S VKE + ++ + A + +++T +DDNI +R Sbjct: 54 DNRVRFYQSDISGVKERTEKTRYAALINQAIEMAEGEYITYATDDNIYM--------PDR 105 Query: 214 VLSGHHWDVKSCDWHPEMGLIASASK 239 +L V+ D HPE +I SASK Sbjct: 106 LLKM----VRELDTHPEKAVIYSASK 127 >2P9P-C nrPDB Length = 372 Score = 29.6 bits (65), Expect = 2.9, Method: Compositional matrix adjust. Identities = 28/122 (22%), Positives = 54/122 (44%), Gaps = 18/122 (14%) Query: 131 MQAHDSAVTTMKYSHDSDWMISGDADGMI-------KIWQPNFSMVKEIDAAHTESIRDM 183 ++ H+ VT + ++ DS+ +++ D + W+P +++ AA R + Sbjct: 48 LKEHNGQVTGVDWAPDSNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAA-----RCV 102 Query: 184 AFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGH-----HWDVKSCDWHPEMGLIASAS 238 ++ N+ KF S ++ I F + + + H V S DWHP L+A+ S Sbjct: 103 RWAPNEKKFAVGSGSRVISICYFEQ-ENDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGS 161 Query: 239 KD 240 D Sbjct: 162 CD 163 Score = 28.9 bits (63), Expect = 4.7, Method: Compositional matrix adjust. Identities = 32/149 (21%), Positives = 59/149 (39%), Gaps = 15/149 (10%) Query: 177 TESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERV--LSGHHWDVKSCDWHPEMGLI 234 E I A++ + ++ C +++ + I+ S K +V L H+ V DW P+ I Sbjct: 8 VEPISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRI 67 Query: 235 ASASKDNLVKLW--DPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIR 292 + D +W R+ IL+ R+ P + + RV I Sbjct: 68 VTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVG----SGSRVISIC 123 Query: 293 YSMKE---LMCVRDE----TDYMTLEWHP 314 Y +E +C + + ++L+WHP Sbjct: 124 YFEQENDWWVCKHIKKPIRSTVLSLDWHP 152 >5AMS-A nrPDB Length = 431 Score = 29.6 bits (65), Expect = 3.0, Method: Compositional matrix adjust. Identities = 51/230 (22%), Positives = 88/230 (38%), Gaps = 36/230 (15%) Query: 66 MPPNAYRGRDRVINL------PSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSL 119 +P G D + +L P KF + + VI + +T EG LV A SG+ + Sbjct: 77 LPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVI-SCSFTSEGGFLVTADMSGKVLV 135 Query: 120 W----NASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPN---------- 165 + + + MQ + V + + G DG + +Q N Sbjct: 136 HMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLM 195 Query: 166 FSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQ-----ERVLSGHHW 220 V + D + E I + N + VTCS D+ + WN G+Q + + G Sbjct: 196 SGFVHQQDCSMGEFI-NTDKGENTLELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEA 254 Query: 221 DVKSCDWHPEM------GLIASASKDNLVKLWDPRSGNCI---SSILKFK 261 S PE G++A S + L+ + + +G I S++++ K Sbjct: 255 PWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLSTVIELK 304 >1XDT-T nrPDB Length = 535 Score = 29.6 bits (65), Expect = 3.2, Method: Compositional matrix adjust. Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 3/75 (4%) Query: 143 YSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESI-RDMAFSSNDSKFVTCSDDNIL 201 YS D++ +SG A G++K+ P + V + + E+I +++ S + + + Sbjct: 65 YSVDNENPLSGKAGGVVKVTYPGLTKVLALKVDNAETIKKELGLSLTEPLMEQVGTEEFI 124 Query: 202 KIWNFSNGKQERVLS 216 K F +G VLS Sbjct: 125 K--RFGDGASRVVLS 137 >6C0F-s nrPDB Length = 807 Score = 29.3 bits (64), Expect = 3.3, Method: Compositional matrix adjust. Identities = 13/34 (38%), Positives = 18/34 (52%) Query: 344 TIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 TI H + +LS +P G AT + D T+R W Sbjct: 431 TIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVW 464 Score = 28.5 bits (62), Expect = 6.4, Method: Compositional matrix adjust. Identities = 9/35 (25%), Positives = 17/35 (48%) Query: 129 TLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ 163 T+ H V T+ W+ +G DG +++W+ Sbjct: 431 TIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWE 465 Score = 28.5 bits (62), Expect = 6.6, Method: Compositional matrix adjust. Identities = 16/79 (20%), Positives = 36/79 (45%), Gaps = 8/79 (10%) Query: 172 IDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLS------GHHWDVKSC 225 I A H +R ++ + T SDD +++W G++ + + ++ Sbjct: 432 IYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECI 491 Query: 226 DWHPEM--GLIASASKDNL 242 +W+P+ G++A A +N+ Sbjct: 492 EWNPDANNGILAVAVGENI 510 Score = 28.5 bits (62), Expect = 6.9, Method: Compositional matrix adjust. Identities = 19/84 (22%), Positives = 34/84 (40%), Gaps = 13/84 (15%) Query: 176 HTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQE---------RVLSGHH----WDV 222 H +++R + F F + +DD + +++ + + L+GH V Sbjct: 722 HEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGV 781 Query: 223 KSCDWHPEMGLIASASKDNLVKLW 246 WHP + SA DN +LW Sbjct: 782 LDAIWHPREAWLFSAGADNTARLW 805 >6EM1-m nrPDB Length = 807 Score = 29.3 bits (64), Expect = 3.4, Method: Compositional matrix adjust. Identities = 13/34 (38%), Positives = 18/34 (52%) Query: 344 TIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 TI H + +LS +P G AT + D T+R W Sbjct: 431 TIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVW 464 Score = 28.9 bits (63), Expect = 5.4, Method: Compositional matrix adjust. Identities = 16/79 (20%), Positives = 36/79 (45%), Gaps = 8/79 (10%) Query: 172 IDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLS------GHHWDVKSC 225 I A H +R ++ + T SDD +++W G++ + + ++ Sbjct: 432 IYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECI 491 Query: 226 DWHPEM--GLIASASKDNL 242 +W+P+ G++A A +N+ Sbjct: 492 EWNPDANNGILAVAVGENI 510 Score = 28.5 bits (62), Expect = 5.7, Method: Compositional matrix adjust. Identities = 9/35 (25%), Positives = 17/35 (48%) Query: 129 TLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ 163 T+ H V T+ W+ +G DG +++W+ Sbjct: 431 TIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWE 465 Score = 28.5 bits (62), Expect = 5.8, Method: Compositional matrix adjust. Identities = 19/84 (22%), Positives = 34/84 (40%), Gaps = 13/84 (15%) Query: 176 HTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQE---------RVLSGHH----WDV 222 H +++R + F F + +DD + +++ + + L+GH V Sbjct: 722 HEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGV 781 Query: 223 KSCDWHPEMGLIASASKDNLVKLW 246 WHP + SA DN +LW Sbjct: 782 LDAIWHPREAWLFSAGADNTARLW 805 >6CB1-s nrPDB Length = 569 Score = 29.3 bits (64), Expect = 3.9, Method: Compositional matrix adjust. Identities = 16/79 (20%), Positives = 36/79 (45%), Gaps = 8/79 (10%) Query: 172 IDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLS------GHHWDVKSC 225 I A H +R ++ + T SDD +++W G++ + + ++ Sbjct: 194 IYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECI 253 Query: 226 DWHPEM--GLIASASKDNL 242 +W+P+ G++A A +N+ Sbjct: 254 EWNPDANNGILAVAVGENI 272 Score = 28.9 bits (63), Expect = 4.7, Method: Compositional matrix adjust. Identities = 13/34 (38%), Positives = 18/34 (52%) Query: 344 TIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 TI H + +LS +P G AT + D T+R W Sbjct: 193 TIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVW 226 Score = 28.9 bits (63), Expect = 4.9, Method: Compositional matrix adjust. Identities = 9/35 (25%), Positives = 17/35 (48%) Query: 129 TLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ 163 T+ H V T+ W+ +G DG +++W+ Sbjct: 193 TIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWE 227 Score = 28.9 bits (63), Expect = 5.2, Method: Compositional matrix adjust. Identities = 19/84 (22%), Positives = 34/84 (40%), Gaps = 13/84 (15%) Query: 176 HTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQE---------RVLSGHH----WDV 222 H +++R + F F + +DD + +++ + + L+GH V Sbjct: 484 HEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGV 543 Query: 223 KSCDWHPEMGLIASASKDNLVKLW 246 WHP + SA DN +LW Sbjct: 544 LDAIWHPREAWLFSAGADNTARLW 567 >6F1U-h nrPDB Length = 612 Score = 28.9 bits (63), Expect = 5.5, Method: Compositional matrix adjust. Identities = 41/196 (20%), Positives = 68/196 (34%), Gaps = 23/196 (11%) Query: 108 LVVATYSGEFSLWNASS--------FTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMI 159 +V TYSG+ LW+ S H + + ++ +IS DG I Sbjct: 322 VVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKI 381 Query: 160 KIW------QPNFSMVKEIDAAHTESIRDMAFSSND-SKFVTCSDDNIL--KIWNFSNGK 210 W P SM + ++ M+F D + FV S++ + + S Sbjct: 382 CSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAG 441 Query: 211 QERVLSGHHWDVKSCDWHPEMG------LIASASKDNLVKLWDPRSGNCISSILKFKHTV 264 + GH + H +G L ++S D VKLW ++ + S V Sbjct: 442 ISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTKNNKPLYSFEDNAGYV 501 Query: 265 LKTRFQPTKGNLLMAI 280 + PT L + Sbjct: 502 YDVMWSPTHPALFACV 517 >1ZUA-X nrPDB Length = 317 Score = 28.5 bits (62), Expect = 7.2, Method: Compositional matrix adjust. Identities = 18/47 (38%), Positives = 25/47 (53%), Gaps = 11/47 (23%) Query: 345 IPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYDDP 391 I Y H K IT +Y+P+G + DR W A+P DP+ +DP Sbjct: 198 IQYCHSKGITVTAYSPLG------SPDRP---W--AKPEDPSLLEDP 233 >1DTP-A nrPDB Length = 190 Score = 28.5 bits (62), Expect = 7.2, Method: Compositional matrix adjust. Identities = 20/83 (24%), Positives = 38/83 (45%), Gaps = 3/83 (3%) Query: 135 DSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESI-RDMAFSSNDSKFV 193 D+ YS D++ +SG A G++K+ P + V + + E+I +++ S + Sbjct: 57 DNKYDAAGYSVDNENPLSGKAGGVVKVTYPGLTKVLALKVDNAETIKKELGLSLTEPLME 116 Query: 194 TCSDDNILKIWNFSNGKQERVLS 216 + +K F +G VLS Sbjct: 117 QVGTEEFIK--RFGDGASRVVLS 137 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6EOJ-D nrPDB 668 0.0 5MZH-A nrPDB 293 2e-79 5NNZ-B nrPDB 289 2e-78 6QX9-4B nrPDB 254 5e-68 1VYH-C nrPDB 251 4e-67 5M25-A nrPDB 249 2e-66 2H9P-A nrPDB 243 1e-64 6N9G-C nrPDB 241 6e-64 6Q8F-A nrPDB 241 7e-64 5UZ7-B nrPDB 228 3e-60 6F3T-A nrPDB 227 9e-60 5G04-R nrPDB 224 8e-59 4GGA-A nrPDB 222 2e-58 5GAN-H nrPDB 221 4e-58 3DM0-A nrPDB 221 6e-58 5LCW-Q nrPDB 217 7e-57 6HQA-B nrPDB 217 9e-57 5NZU-C nrPDB 215 3e-56 6ID0-T nrPDB 215 4e-56 5FL8-q nrPDB 213 9e-56 6MZM-G nrPDB 212 2e-55 3FM0-A nrPDB 212 3e-55 6QX9-5O nrPDB 211 5e-55 4V7E-Bg nrPDB 209 2e-54 4V6W-Ag nrPDB 207 7e-54 4N14-A nrPDB 205 3e-53 5OPT-p nrPDB 205 3e-53 6EMK-B nrPDB 204 4e-53 5FVM-C nrPDB 204 5e-53 4V8M-A7 nrPDB 204 7e-53 6G51-g nrPDB 204 8e-53 5WLC-LO nrPDB 198 6e-51 3MKQ-A nrPDB 196 1e-50 5I2T-A nrPDB 195 3e-50 5Y88-O nrPDB 192 2e-49 2YNP-A nrPDB 192 3e-49 6HHQ-h nrPDB 189 2e-48 4AEZ-A nrPDB 187 9e-48 6GMH-W nrPDB 184 5e-47 5OQL-d nrPDB 183 1e-46 4BTS-AR nrPDB 179 2e-45 5Z56-q nrPDB 177 7e-45 5L9T-R nrPDB 177 1e-44 2HES-X nrPDB 176 1e-44 4LG8-A nrPDB 175 5e-44 3JAP-g nrPDB 170 1e-42 5WYK-BB nrPDB 169 2e-42 5K1B-B nrPDB 168 4e-42 6QDV-o nrPDB 166 1e-41 5YZG-W nrPDB 166 2e-41 5Y1U-A nrPDB 165 3e-41 5WLC-LU nrPDB 165 3e-41 3JB9-L nrPDB 165 5e-41 5WYJ-BC nrPDB 164 5e-41 3CFV-B nrPDB 161 5e-40 4J0W-A nrPDB 161 6e-40 5OQL-J nrPDB 161 7e-40 4YCZ-A nrPDB 159 2e-39 5FA5-B nrPDB 159 2e-39 5XYI-g nrPDB 154 5e-38 5N4A-A nrPDB 152 3e-37 4G56-B nrPDB 152 3e-37 5WYJ-BE nrPDB 149 2e-36 3JRO-A nrPDB 149 3e-36 4L9O-A nrPDB 142 3e-34 6BX3-A nrPDB 142 4e-34 5WBU-D nrPDB 141 5e-34 5K0Y-T nrPDB 141 1e-33 3JRP-A nrPDB 140 1e-33 3JB9-g nrPDB 138 4e-33 5WLC-LJ nrPDB 138 6e-33 1NR0-A nrPDB 138 6e-33 3ODT-A nrPDB 137 6e-33 5OQL-L nrPDB 137 1e-32 4BZK-B nrPDB 137 1e-32 6CHG-A nrPDB 136 3e-32 4A11-B nrPDB 135 3e-32 5WJC-A nrPDB 135 3e-32 4U1E-I nrPDB 135 4e-32 4PSX-B nrPDB 133 1e-31 3F3P-A nrPDB 131 7e-31 6ELZ-p nrPDB 130 1e-30 5MWJ-A nrPDB 128 4e-30 1PI6-A nrPDB 128 6e-30 6J6H-n nrPDB 127 1e-29 5OQL-X nrPDB 125 4e-29 3BG0-A nrPDB 124 7e-29 2AQ5-A nrPDB 122 4e-28 4OWR-A nrPDB 118 4e-27 3ACP-A nrPDB 118 5e-27 5K19-A nrPDB 117 1e-26 5OV3-A nrPDB 116 2e-26 5CXC-A nrPDB 112 3e-25 6E29-D nrPDB 110 9e-25 2PM9-A nrPDB 108 5e-24 5A9Q-7 nrPDB 104 7e-23 5A9Q-0 nrPDB 99 4e-21 5TF2-A nrPDB 67 2e-11 Sequences not found previously or not previously below threshold: 3C9C-A nrPDB 159 2e-39 5A31-R nrPDB 142 3e-34 4BH6-A nrPDB 140 1e-33 4XYI-A nrPDB 137 1e-32 4XFV-A nrPDB 121 7e-28 6F1U-h nrPDB 105 3e-23 5M89-A nrPDB 101 7e-22 5CXB-B nrPDB 100 1e-21 3W15-A nrPDB 99 4e-21 3EI3-B nrPDB 98 1e-20 6BX3-B nrPDB 97 2e-20 5WLC-LN nrPDB 97 2e-20 4E5Z-B nrPDB 97 2e-20 5WLC-SG nrPDB 95 8e-20 4J0X-A nrPDB 95 8e-20 6C0F-s nrPDB 94 2e-19 6CB1-s nrPDB 94 2e-19 6EM1-m nrPDB 93 2e-19 3I2N-A nrPDB 93 3e-19 3JZG-A nrPDB 92 6e-19 6CHG-D nrPDB 92 6e-19 2P9P-C nrPDB 90 2e-18 5A9Q-2 nrPDB 87 1e-17 5BJS-A nrPDB 87 1e-17 3JB9-S nrPDB 87 2e-17 5MC6-j nrPDB 82 6e-16 5YZG-2 nrPDB 77 1e-14 5AJA-A nrPDB 74 1e-13 3DWL-C nrPDB 73 2e-13 5WLC-LW nrPDB 73 2e-13 5WLC-LV nrPDB 68 8e-12 5AMS-A nrPDB 64 1e-10 2I3T-A nrPDB 63 2e-10 5LTD-A nrPDB 63 3e-10 6IYY-A nrPDB 62 5e-10 3DW8-B nrPDB 62 5e-10 5K1H-B nrPDB 59 3e-09 5WLC-LH nrPDB 57 2e-08 5WLC-LS nrPDB 56 3e-08 6CVZ-A nrPDB 56 3e-08 4FHN-A nrPDB 56 4e-08 6N8P-A nrPDB 54 2e-07 4AV8-A nrPDB 53 2e-07 3WJ9-A nrPDB 49 3e-06 2VDU-B nrPDB 49 4e-06 5WLC-LL nrPDB 48 8e-06 5BPW-A nrPDB 42 7e-04 3TKN-A nrPDB 41 0.001 5BPT-A nrPDB 41 0.001 4YHC-A nrPDB 40 0.002 6FYY-p nrPDB 40 0.002 5GRS-A nrPDB 39 0.005 4NOX-A nrPDB 38 0.009 6NAU-A nrPDB 37 0.019 6IGB-A nrPDB 37 0.020 1RI6-A nrPDB 37 0.020 4U1F-A nrPDB 37 0.022 4MHC-A nrPDB 37 0.023 2J04-A nrPDB 36 0.033 4IMM-A nrPDB 35 0.065 5TXC-A nrPDB 35 0.079 5CWW-B nrPDB 34 0.13 6GC1-A nrPDB 34 0.16 3AZQ-A nrPDB 33 0.31 2FAW-A nrPDB 32 0.39 1Z68-A nrPDB 32 0.49 5UE8-A nrPDB 31 1.0 2GBG-A nrPDB 30 1.5 2VR2-A nrPDB 30 1.5 1XFD-A nrPDB 30 1.9 6FTI-5 nrPDB 30 2.0 3NCG-A nrPDB 30 2.0 3DFA-A nrPDB 30 2.0 3R3L-A nrPDB 30 2.9 3FE4-A nrPDB 30 3.1 1FLG-A nrPDB 29 3.7 3MWP-A nrPDB 29 4.1 6NYT-A nrPDB 29 4.4 2FTW-A nrPDB 29 4.8 1SVV-A nrPDB 29 4.8 1OA3-A nrPDB 28 7.9 >6EOJ-D nrPDB Length = 470 Score = 668 bits (1723), Expect = 0.0, Method: Composition-based stats. Identities = 465/465 (100%), Positives = 465/465 (100%) Query: 1 MDGHNQNQYQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETS 60 MDGHNQNQYQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETS Sbjct: 1 MDGHNQNQYQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETS 60 Query: 61 YTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLW 120 YTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLW Sbjct: 61 YTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLW 120 Query: 121 NASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESI 180 NASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESI Sbjct: 121 NASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESI 180 Query: 181 RDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKD 240 RDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKD Sbjct: 181 RDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKD 240 Query: 241 NLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMC 300 NLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMC Sbjct: 241 NLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMC 300 Query: 301 VRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNP 360 VRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNP Sbjct: 301 VRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNP 360 Query: 361 VGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFFGINNDINAVREKSEFGA 420 VGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFFGINNDINAVREKSEFGA Sbjct: 361 VGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFFGINNDINAVREKSEFGA 420 Query: 421 APPPPATLEPHALPNMNGFINKKPRQEIPGIDSNIKSSTLPGLSI 465 APPPPATLEPHALPNMNGFINKKPRQEIPGIDSNIKSSTLPGLSI Sbjct: 421 APPPPATLEPHALPNMNGFINKKPRQEIPGIDSNIKSSTLPGLSI 465 >5MZH-A nrPDB Length = 452 Score = 293 bits (749), Expect = 2e-79, Method: Composition-based stats. Identities = 75/316 (23%), Positives = 132/316 (41%), Gaps = 6/316 (1%) Query: 64 DIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWT-PEGRRLVVATYSGEFSLWNA 122 D +Y +V N + + K+V+ AI + P G ++V ++ LW+A Sbjct: 107 DRFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDA 166 Query: 123 SSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRD 182 + ++ H + + + ++ S + +G D K+W + A H I Sbjct: 167 YTGQLYYTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETGQERATLAGHRAEIVS 226 Query: 183 MAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNL 242 + F++ VT S D+ ++W+ G+ VLSGH +V S ++ L+ S S D Sbjct: 227 LGFNTGGDLIVTGSFDHDSRLWDVRTGQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCT 286 Query: 243 VKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVR 302 +LWD RSG C+S VL F G +++ S D S R++ + + V Sbjct: 287 SRLWDVRSGRCLSVKQGHTDEVLDVAFDAA-GTKMVSASADGSARLYHTLTGVCQHTLVG 345 Query: 303 DETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVG 362 E + + ++P + A D + + +D L + H I S ++N G Sbjct: 346 HEGEISKVAFNPQG-TRLITASSDKTCRLWDCDTG---ECLQVLEGHTDEIFSCAFNYEG 401 Query: 363 HIFATAAKDRTIRFWT 378 T +KD T R W Sbjct: 402 DFIITGSKDNTCRIWK 417 Score = 270 bits (691), Expect = 7e-73, Method: Composition-based stats. Identities = 72/349 (20%), Positives = 139/349 (39%), Gaps = 16/349 (4%) Query: 76 RVINLPSKFTHLSSN------KVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFET 129 R+I+ + H S + + G R + +Y +WN + Sbjct: 71 RLIDKMLEQQHHSFTLFKVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVF 130 Query: 130 LMQAHDSAVTTMKY-SHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSN 188 ++ H + V + + + D +++G D K+W + H I ++F+ Sbjct: 131 TLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQ 190 Query: 189 DSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDP 248 + T S DN K+W+ G++ L+GH ++ S ++ LI + S D+ +LWD Sbjct: 191 STIIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDV 250 Query: 249 RSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYM 308 R+G C+ + + V T+F G L+++ S D + R++D+R + + + Sbjct: 251 RTGQCVHVLSGHRGEVSSTQFN-YAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVL 309 Query: 309 TLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATA 368 + + M A DGS + + L + + H+ I+ +++NP G TA Sbjct: 310 DVAFDAAGTKM-VSASADGSARLYHTLTGVCQ---HTLVGHEGEISKVAFNPQGTRLITA 365 Query: 369 AKDRTIRFW--TRARPIDPNAYDDPTYNNKKIN--GWFFGINNDINAVR 413 + D+T R W + + N G F + N R Sbjct: 366 SSDKTCRLWDCDTGECLQVLEGHTDEIFSCAFNYEGDFIITGSKDNTCR 414 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 51/297 (17%), Positives = 119/297 (40%), Gaps = 20/297 (6%) Query: 1 MDGHNQ-------NQYQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNL 53 ++GH N + S K + LYY + + Sbjct: 132 LEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTG---------QLYYTLKGHQTEI 182 Query: 54 V-VEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVAT 112 V + TI + + ++ ++ + + + I ++ + G +V + Sbjct: 183 VCLSFNPQSTI--IATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGS 240 Query: 113 YSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEI 172 + + LW+ + ++ H V++ ++++ ++SG D ++W + Sbjct: 241 FDHDSRLWDVRTGQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSV 300 Query: 173 DAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMG 232 HT+ + D+AF + +K V+ S D ++++ G + L GH ++ ++P+ Sbjct: 301 KQGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGT 360 Query: 233 LIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVF 289 + +AS D +LWD +G C+ + + F +G+ ++ SKD +CR++ Sbjct: 361 RLITASSDKTCRLWDCDTGECLQVLEGHTDEIFSCAFN-YEGDFIITGSKDNTCRIW 416 Score = 132 bits (331), Expect = 4e-31, Method: Composition-based stats. Identities = 24/157 (15%), Positives = 61/157 (38%) Query: 54 VVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATY 113 V + +Y ++ + R+ ++ S + + + G ++V A+ Sbjct: 266 VSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEVLDVAFDAAGTKMVSASA 325 Query: 114 SGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEID 173 G L++ + + + H+ ++ + ++ +I+ +D ++W + ++ Sbjct: 326 DGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTRLITASSDKTCRLWDCDTGECLQVL 385 Query: 174 AAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGK 210 HT+ I AF+ +T S DN +IW Sbjct: 386 EGHTDEIFSCAFNYEGDFIITGSKDNTCRIWKALTAS 422 Score = 48.6 bits (114), Expect = 5e-06, Method: Composition-based stats. Identities = 11/111 (9%), Positives = 29/111 (26%), Gaps = 10/111 (9%) Query: 14 QIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRG 73 + S + Y T + + + P+ + I + Sbjct: 320 MVSASADGSARLYHTLTGVCQ------HTLVGHEGEISKVAFNPQGTRLIT----ASSDK 369 Query: 74 RDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASS 124 R+ + + I + + EG ++ + +W A + Sbjct: 370 TCRLWDCDTGECLQVLEGHTDEIFSCAFNYEGDFIITGSKDNTCRIWKALT 420 >5NNZ-B nrPDB Length = 415 Score = 289 bits (740), Expect = 2e-78, Method: Composition-based stats. Identities = 66/334 (19%), Positives = 138/334 (41%), Gaps = 10/334 (2%) Query: 46 RRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWT-PE 104 L N+ + + + +Y ++ + S + ++V+ AI + P Sbjct: 91 HILPLTNVAL----NKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPY 146 Query: 105 GRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQP 164 G ++ ++ LW+ + + H + + + ++ S + +G D K+W Sbjct: 147 GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDI 206 Query: 165 NFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKS 224 H+ I ++F+++ + +T S D+ + +W+ G++ +L GH ++ S Sbjct: 207 QNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISS 266 Query: 225 CDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDK 284 ++ + LI + S D KLWD +G C++++ +L + F T G L+ S D Sbjct: 267 ASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYT-GKLIATASADG 325 Query: 285 SCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILT 344 + R+F E + + ++P + T D + + +D L Sbjct: 326 TARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLT-GSSDKTARIWDAQTG---QCLQ 381 Query: 345 IPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWT 378 + H I S ++N G+I T +KD T R W Sbjct: 382 VLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415 Score = 255 bits (651), Expect = 3e-68, Method: Composition-based stats. Identities = 60/324 (18%), Positives = 122/324 (37%), Gaps = 10/324 (3%) Query: 95 VIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYS-HDSDWMISG 153 + + G + +Y LW+ +S ++ H + V + ++ D + +G Sbjct: 94 PLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATG 153 Query: 154 DADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQER 213 D K+W HT I ++F+ + T S D K+W+ NG++ Sbjct: 154 SFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVY 213 Query: 214 VLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTK 273 L GH ++ S ++ I + S D+ V +WD +G ++ ++ + F Sbjct: 214 TLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFN-WD 272 Query: 274 GNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFD 333 +L++ S DK+C+++D + + + + + A DG+ + F Sbjct: 273 CSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFD-YTGKLIATASADGTARIFS 331 Query: 334 LLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWT--RARPIDPNAYDDP 391 + H+ I+ +S+NP G+ T + D+T R W + + Sbjct: 332 AATR---KCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTD 388 Query: 392 TYNNKKIN--GWFFGINNDINAVR 413 + N G + N R Sbjct: 389 EIFSCAFNYKGNIVITGSKDNTCR 412 Score = 223 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 60/295 (20%), Positives = 113/295 (38%), Gaps = 10/295 (3%) Query: 124 SFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDM 183 +F +++AH +T + + I+G D K+W H + + Sbjct: 81 TFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAI 140 Query: 184 AF-SSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNL 242 AF + K T S D K+W+ GK GH ++ ++P+ L+A+ S D Sbjct: 141 AFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTT 200 Query: 243 VKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVR 302 KLWD ++G + ++ ++ F T G+ ++ S D + V+D K + + Sbjct: 201 AKLWDIQNGEEVYTLRGHSAEIISLSFN-TSGDRIITGSFDHTVVVWDADTGRKVNILIG 259 Query: 303 DETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVG 362 + + ++ + S+ D + K +D N + HD I ++ G Sbjct: 260 HCAEISSASFN-WDCSLILTGSMDKTCKLWDA---TNGKCVATLTGHDDEILDSCFDYTG 315 Query: 363 HIFATAAKDRTIRFWTRARP--IDPNAYDDPTYNNKKIN--GWFFGINNDINAVR 413 + ATA+ D T R ++ A I + + N G + R Sbjct: 316 KLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTAR 370 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 54/318 (16%), Positives = 125/318 (39%), Gaps = 11/318 (3%) Query: 15 IQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGR 74 I S K + T S +N R+ + + D + ++ Sbjct: 108 ITGSYDRTCKLWDT------ASGEELNTLEGHRNVVYAIAFNNPYG---DKIATGSFDKT 158 Query: 75 DRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAH 134 ++ ++ + + + I + + P+ + + LW+ + ++ H Sbjct: 159 CKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGH 218 Query: 135 DSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVT 194 + + ++ ++ D +I+G D + +W + I H I +F+ + S +T Sbjct: 219 SAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILT 278 Query: 195 CSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCI 254 S D K+W+ +NGK L+GH ++ + LIA+AS D +++ + CI Sbjct: 279 GSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCI 338 Query: 255 SSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHP 314 + + + + K F P +GN L+ S DK+ R++D + + + + ++ Sbjct: 339 AKLEGHEGEISKISFNP-QGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFN- 396 Query: 315 INESMFTLACYDGSLKHF 332 ++ D + + + Sbjct: 397 YKGNIVITGSKDNTCRIW 414 Score = 54.7 bits (130), Expect = 8e-08, Method: Composition-based stats. Identities = 21/137 (15%), Positives = 40/137 (29%), Gaps = 13/137 (9%) Query: 290 DIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLL--------QNLNEP 341 +++ +L+ + TD L A +K N Sbjct: 24 ELKTKSIDLLDLGPSTDVSALVEEIQKAEPLLTASRTEQVKLLIQRLQEKLGQNSNHTFY 83 Query: 342 ILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRA--RPIDPNAYDDPTYNNKKIN 399 + + AH +T+++ N G F T + DRT + W A ++ N Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143 Query: 400 ---GWFFGINNDINAVR 413 G + + Sbjct: 144 NPYGDKIATGSFDKTCK 160 >6QX9-4B nrPDB Length = 522 Score = 254 bits (649), Expect = 5e-68, Method: Composition-based stats. Identities = 66/351 (18%), Positives = 127/351 (36%), Gaps = 14/351 (3%) Query: 37 SPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDR--VINLPSKFTHLSSNKVKH 94 S + + + LP + E + +P + + +L S S Sbjct: 173 SLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDR 232 Query: 95 VIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDW----- 149 I ++P + L A +SG LW+ ++ H++ V + + S Sbjct: 233 PISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPK 292 Query: 150 ---MISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNF 206 + S ADG +K+W + HT + + + + T D ++W+ Sbjct: 293 DVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDL 352 Query: 207 SNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLK 266 ++ GH V +H + L + D ++WD R+G CI + + Sbjct: 353 EAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYG 412 Query: 267 TRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYD 326 F P G + S D +C+V+D+R + +++ PI+ + YD Sbjct: 413 INFSP-NGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYD 471 Query: 327 GSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 + K + + L H+ + L + G + AT + DRT + W Sbjct: 472 NTAKIW---THPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519 Score = 159 bits (401), Expect = 3e-39, Method: Composition-based stats. Identities = 52/261 (19%), Positives = 93/261 (35%), Gaps = 18/261 (6%) Query: 175 AHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGL- 233 I FS N T + K+W+ + L GH+ +V + +HP+ + Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288 Query: 234 -------IASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSC 286 +AS + D VKLW S ++ I V + + P+ G L D+S Sbjct: 289 LDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPS-GRFLGTTCYDRSW 347 Query: 287 RVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIP 346 R++D+ + L + +H + S+ D + +DL + Sbjct: 348 RLWDLEAQEEILHQEGHSMGVYDIAFH-QDGSLAGTGGLDAFGRVWDLRTG---RCIMFL 403 Query: 347 YAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARP--IDPNAYDDPTYNNKKIN---GW 401 H K I ++++P G+ AT + D T + W + + K G Sbjct: 404 EGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGN 463 Query: 402 FFGINNDINAVREKSEFGAAP 422 F N + + G +P Sbjct: 464 FLLTGAYDNTAKIWTHPGWSP 484 >1VYH-C nrPDB Length = 410 Score = 251 bits (641), Expect = 4e-67, Method: Composition-based stats. Identities = 61/318 (19%), Positives = 125/318 (39%), Gaps = 23/318 (7%) Query: 80 LPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVT 139 +P + + + + + + P +V A+ +W+ + FE ++ H +V Sbjct: 95 IPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQ 154 Query: 140 TMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDN 199 + + H + S AD IK+W H ++ ++ N V+ S D Sbjct: 155 DISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDK 214 Query: 200 ILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILK 259 +K+W G + +GH V+ + + LIAS S D V++W + C + + + Sbjct: 215 TIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELRE 274 Query: 260 FKHTVLKTRFQPTK-------------------GNLLMAISKDKSCRVFDIRYSMKELMC 300 +H V + P G L++ S+DK+ +++D+ M + Sbjct: 275 HRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTL 334 Query: 301 VRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNP 360 V + + +H D +L+ +D N+ + AH+ +TSL ++ Sbjct: 335 VGHDNWVRGVLFHS-GGKFILSCADDKTLRVWDY---KNKRCMKTLNAHEHFVTSLDFHK 390 Query: 361 VGHIFATAAKDRTIRFWT 378 T + D+T++ W Sbjct: 391 TAPYVVTGSVDQTVKVWE 408 Score = 231 bits (588), Expect = 6e-61, Method: Composition-based stats. Identities = 59/309 (19%), Positives = 116/309 (37%), Gaps = 27/309 (8%) Query: 128 ETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSS 187 + + H S VT + + M+S D IK+W + HT+S++D++F Sbjct: 101 KYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDH 160 Query: 188 NDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWD 247 + +CS D +K+W+F + R + GH +V S P I SAS+D +K+W+ Sbjct: 161 SGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWE 220 Query: 248 PRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDY 307 ++G C+ + + V R G L+ + S D++ RV+ + + Sbjct: 221 VQTGYCVKTFTGHREWVRMVRPN-QDGTLIASCSNDQTVRVWVVATKECKAELREHRHVV 279 Query: 308 MTLEWHPIN-------------------ESMFTLACYDGSLKHFDLLQNLNEPILTIPYA 348 + W P + D ++K +D+ + L Sbjct: 280 ECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGM---CLMTLVG 336 Query: 349 HDKCITSLSYNPVGHIFATAAKDRTIRFWTRARP--IDPNAYDDPTYNNKKIN--GWFFG 404 HD + + ++ G + A D+T+R W + + + + + Sbjct: 337 HDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVV 396 Query: 405 INNDINAVR 413 + V+ Sbjct: 397 TGSVDQTVK 405 Score = 221 bits (562), Expect = 7e-58, Method: Composition-based stats. Identities = 54/310 (17%), Positives = 116/310 (37%), Gaps = 26/310 (8%) Query: 46 RRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEG 105 R + ++ P +M + +V + + + + I + G Sbjct: 107 HRSPVTRVIFHP----VFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSG 162 Query: 106 RRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPN 165 + L + LW+ F M HD V+++ + D ++S D IK+W+ Sbjct: 163 KLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWEVQ 222 Query: 166 FSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSC 225 + H E +R + + + + +CS+D +++W + + + L H V+ Sbjct: 223 TGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHRHVVECI 282 Query: 226 DWHPEMGL--------------------IASASKDNLVKLWDPRSGNCISSILKFKHTVL 265 W PE + S S+D +K+WD +G C+ +++ + V Sbjct: 283 SWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVR 342 Query: 266 KTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACY 325 F + G +++ + DK+ RV+D + E +L++H Sbjct: 343 GVLFH-SGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKT-APYVVTGSV 400 Query: 326 DGSLKHFDLL 335 D ++K ++ Sbjct: 401 DQTVKVWECR 410 Score = 197 bits (501), Expect = 7e-51, Method: Composition-based stats. Identities = 45/299 (15%), Positives = 105/299 (35%), Gaps = 31/299 (10%) Query: 14 QIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRG 73 + S+ +K + D + G + V + ++ ++ + Sbjct: 123 MVSASEDATIKVW-------DYETGDFERTLK---GHTDSVQDISFDHSGKLLASCSADM 172 Query: 74 RDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQA 133 ++ + + + H + ++ P G +V A+ +W + Sbjct: 173 TIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTG 232 Query: 134 HDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSK-- 191 H V ++ + D + S D +++W K H + ++++ S Sbjct: 233 HREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHRHVVECISWAPESSYSS 292 Query: 192 ------------------FVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGL 233 ++ S D +K+W+ S G L GH V+ +H Sbjct: 293 ISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKF 352 Query: 234 IASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIR 292 I S + D +++WD ++ C+ ++ +H V F T + + S D++ +V++ R Sbjct: 353 ILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYV-VTGSVDQTVKVWECR 410 Score = 41.3 bits (95), Expect = 8e-04, Method: Composition-based stats. Identities = 10/45 (22%), Positives = 19/45 (42%) Query: 335 LQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTR 379 P H +T + ++PV + +A++D TI+ W Sbjct: 93 EWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDY 137 >5M25-A nrPDB Length = 434 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 68/260 (26%), Positives = 120/260 (46%), Gaps = 1/260 (0%) Query: 123 SSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRD 182 ++ + + H AV+++K+S + +W+ S AD +IKIW ++ + H I D Sbjct: 133 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISD 192 Query: 183 MAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNL 242 +A+SS+ + V+ SDD LKIW+ S+GK + L GH V C+++P+ LI S S D Sbjct: 193 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 252 Query: 243 VKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVR 302 V++WD ++G C+ ++ V F G+L+++ S D CR++D + Sbjct: 253 VRIWDVKTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASGQCLKTLID 311 Query: 303 DETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVG 362 D+ ++ N A D +LK +D + T CI + G Sbjct: 312 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG 371 Query: 363 HIFATAAKDRTIRFWTRARP 382 + ++D + W Sbjct: 372 KWIVSGSEDNLVYIWNLQTK 391 Score = 249 bits (635), Expect = 3e-66, Method: Composition-based stats. Identities = 61/303 (20%), Positives = 128/303 (42%), Gaps = 9/303 (2%) Query: 81 PSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTT 140 P+ + + +++++P G L ++ +W A FE + H ++ Sbjct: 133 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISD 192 Query: 141 MKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNI 200 + +S DS+ ++S D +KIW + + H+ + F+ + V+ S D Sbjct: 193 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 252 Query: 201 LKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKF 260 ++IW+ GK + L H V + ++ + LI S+S D L ++WD SG C+ +++ Sbjct: 253 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD 312 Query: 261 KH-TVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTL--EWHPINE 317 + V +F P G ++A + D + +++D + + + + Sbjct: 313 DNPPVSFVKFSP-NGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG 371 Query: 318 SMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAA--KDRTIR 375 D + ++L + I+ H + S + +P +I A+AA D+TI+ Sbjct: 372 KWIVSGSEDNLVYIWNL---QTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIK 428 Query: 376 FWT 378 W Sbjct: 429 LWK 431 Score = 207 bits (527), Expect = 8e-54, Method: Composition-based stats. Identities = 52/291 (17%), Positives = 117/291 (40%), Gaps = 8/291 (2%) Query: 46 RRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEG 105 + ++ P + + ++ ++ + + K I + W+ + Sbjct: 144 HTKAVSSVKFSPNGEW----LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 199 Query: 106 RRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPN 165 LV A+ +W+ SS ++ H + V ++ S+ ++SG D ++IW Sbjct: 200 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 259 Query: 166 FSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHW-DVKS 224 + AH++ + + F+ + S V+ S D + +IW+ ++G+ + L V Sbjct: 260 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSF 319 Query: 225 CDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKT--RFQPTKGNLLMAISK 282 + P I +A+ DN +KLWD G C+ + K+ F T G +++ S+ Sbjct: 320 VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSE 379 Query: 283 DKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACY-DGSLKHF 332 D +++++ ++ HP + + A D ++K + Sbjct: 380 DNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 430 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 45/284 (15%), Positives = 114/284 (40%), Gaps = 17/284 (5%) Query: 12 QNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAY 71 + S +K + + + G+ ++ +++ ++ + Sbjct: 158 EWLASSSADKLIKIWGAYDGKFE------KTISGHKLGISDVAWSSDSN----LLVSASD 207 Query: 72 RGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLM 131 ++ ++ S + + + + P+ +V ++ +W+ + + Sbjct: 208 DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL 267 Query: 132 QAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ-PNFSMVKEIDAAHTESIRDMAFSSNDS 190 AH V+ + ++ D ++S DG+ +IW + +K + + + FS N Sbjct: 268 PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGK 327 Query: 191 KFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPE---MGLIASASKDNLVKLWD 247 + + DN LK+W++S GK + +GH + + I S S+DNLV +W+ Sbjct: 328 YILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 387 Query: 248 PRSGNCISSILKFKHTVLKTRFQPTKGNLLMAIS--KDKSCRVF 289 ++ + + V+ T PT+ N++ + + DK+ +++ Sbjct: 388 LQTKEIVQKLQGHTDVVISTACHPTE-NIIASAALENDKTIKLW 430 >2H9P-A nrPDB Length = 329 Score = 243 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 68/260 (26%), Positives = 120/260 (46%), Gaps = 1/260 (0%) Query: 123 SSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRD 182 ++ + + H AV+++K+S + +W+ S AD +IKIW ++ + H I D Sbjct: 28 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISD 87 Query: 183 MAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNL 242 +A+SS+ + V+ SDD LKIW+ S+GK + L GH V C+++P+ LI S S D Sbjct: 88 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 147 Query: 243 VKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVR 302 V++WD ++G C+ ++ V F G+L+++ S D CR++D + Sbjct: 148 VRIWDVKTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASGQCLKTLID 206 Query: 303 DETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVG 362 D+ ++ N A D +LK +D + T CI + G Sbjct: 207 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG 266 Query: 363 HIFATAAKDRTIRFWTRARP 382 + ++D + W Sbjct: 267 KWIVSGSEDNLVYIWNLQTK 286 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 61/303 (20%), Positives = 128/303 (42%), Gaps = 9/303 (2%) Query: 81 PSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTT 140 P+ + + +++++P G L ++ +W A FE + H ++ Sbjct: 28 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISD 87 Query: 141 MKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNI 200 + +S DS+ ++S D +KIW + + H+ + F+ + V+ S D Sbjct: 88 VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 147 Query: 201 LKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKF 260 ++IW+ GK + L H V + ++ + LI S+S D L ++WD SG C+ +++ Sbjct: 148 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD 207 Query: 261 KH-TVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTL--EWHPINE 317 + V +F P G ++A + D + +++D + + + + Sbjct: 208 DNPPVSFVKFSP-NGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG 266 Query: 318 SMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAA--KDRTIR 375 D + ++L + I+ H + S + +P +I A+AA D+TI+ Sbjct: 267 KWIVSGSEDNLVYIWNL---QTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIK 323 Query: 376 FWT 378 W Sbjct: 324 LWK 326 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 52/291 (17%), Positives = 117/291 (40%), Gaps = 8/291 (2%) Query: 46 RRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEG 105 + ++ P + + ++ ++ + + K I + W+ + Sbjct: 39 HTKAVSSVKFSPNGEW----LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 94 Query: 106 RRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPN 165 LV A+ +W+ SS ++ H + V ++ S+ ++SG D ++IW Sbjct: 95 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 154 Query: 166 FSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHW-DVKS 224 + AH++ + + F+ + S V+ S D + +IW+ ++G+ + L V Sbjct: 155 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSF 214 Query: 225 CDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKT--RFQPTKGNLLMAISK 282 + P I +A+ DN +KLWD G C+ + K+ F T G +++ S+ Sbjct: 215 VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSE 274 Query: 283 DKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACY-DGSLKHF 332 D +++++ ++ HP + + A D ++K + Sbjct: 275 DNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 325 Score = 184 bits (468), Expect = 5e-47, Method: Composition-based stats. Identities = 45/284 (15%), Positives = 113/284 (39%), Gaps = 17/284 (5%) Query: 12 QNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAY 71 + S +K + + + G+ ++ +++ ++ + Sbjct: 53 EWLASSSADKLIKIWGAYDGKFE------KTISGHKLGISDVAWSSDSN----LLVSASD 102 Query: 72 RGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLM 131 ++ ++ S + + + + P+ +V ++ +W+ + + Sbjct: 103 DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL 162 Query: 132 QAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFS-MVKEIDAAHTESIRDMAFSSNDS 190 AH V+ + ++ D ++S DG+ +IW +K + + + FS N Sbjct: 163 PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGK 222 Query: 191 KFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPE---MGLIASASKDNLVKLWD 247 + + DN LK+W++S GK + +GH + + I S S+DNLV +W+ Sbjct: 223 YILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 282 Query: 248 PRSGNCISSILKFKHTVLKTRFQPTKGNLLMAIS--KDKSCRVF 289 ++ + + V+ T PT+ N++ + + DK+ +++ Sbjct: 283 LQTKEIVQKLQGHTDVVISTACHPTE-NIIASAALENDKTIKLW 325 >6N9G-C nrPDB Length = 353 Score = 241 bits (614), Expect = 6e-64, Method: Composition-based stats. Identities = 60/297 (20%), Positives = 129/297 (43%), Gaps = 13/297 (4%) Query: 90 NKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDW 149 + + + W + RR+V ++ G+ +W++ + E + + V Y+ Sbjct: 60 KGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCA 119 Query: 150 MISGDADGMIKIW------QPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKI 203 + G D ++ N + K+ A HT + +F+++D + +T S D + Sbjct: 120 IACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCAL 179 Query: 204 WNFSNGKQERVLSGHHWDVKSCDWHPE--MGLIASASKDNLVKLWDPRSGNCISSILKFK 261 W+ +G+ + GH DV D P S D +WD RSG C+ + + Sbjct: 180 WDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHE 239 Query: 262 HTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDY-MTLEWHPINESMF 320 V R+ P+ G+ + S D +CR++D+R + + ++ + + ++ + Sbjct: 240 SDVNSVRYYPS-GDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLL 298 Query: 321 TLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 D ++ +D+L+ ++I + H+ +++L +P G F + + D T+R W Sbjct: 299 FAGYNDYTINVWDVLKGSR---VSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352 Score = 159 bits (401), Expect = 3e-39, Method: Composition-based stats. Identities = 44/276 (15%), Positives = 103/276 (37%), Gaps = 10/276 (3%) Query: 66 MPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLW----- 120 + ++ G+ V + + + + A + P G + + S++ Sbjct: 78 IVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFD 137 Query: 121 -NASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTES 179 N + + + H + ++ +++ +++ DG +W + + H Sbjct: 138 KNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGAD 197 Query: 180 IRDMAFSSN--DSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASA 237 + + + + + FV+ D +W+ +G+ + H DV S ++P AS Sbjct: 198 VLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDVNSVRYYPSGDAFASG 257 Query: 238 SKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPT-KGNLLMAISKDKSCRVFDIRYSMK 296 S D +L+D R+ ++ K + + G LL A D + V+D+ + Sbjct: 258 SDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSR 317 Query: 297 ELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHF 332 + E TL P + + F +D +L+ + Sbjct: 318 VSILFGHENRVSTLRVSP-DGTAFCSGSWDHTLRVW 352 Score = 150 bits (379), Expect = 1e-36, Method: Composition-based stats. Identities = 43/292 (14%), Positives = 99/292 (33%), Gaps = 23/292 (7%) Query: 9 YQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLP-NLVVEPETSYTIDIMP 67 + + SQ + + +P V+ + + + Sbjct: 73 KDKRRIVSSSQDGKVIVWD-----------SFTTNKEHAVTMPCTWVMACAYAPSGCAIA 121 Query: 68 PNAYRGRDRVINLP-SKFTHLSSNK-----VKHVIPAIQWTPEGRRLVVATYSGEFSLWN 121 + V L K ++++ K + + A +T +++ A+ G +LW+ Sbjct: 122 CGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWD 181 Query: 122 ASSFTFETLMQAHDSAVTTMKYSH--DSDWMISGDADGMIKIWQPNFSMVKEIDAAHTES 179 S H + V + + + +SG D +W + H Sbjct: 182 VESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESD 241 Query: 180 IRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHH--WDVKSCDWHPEMGLIASA 237 + + + + F + SDD ++++ ++ + S + S D+ L+ + Sbjct: 242 VNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAG 301 Query: 238 SKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVF 289 D + +WD G+ +S + ++ V R P G + S D + RV+ Sbjct: 302 YNDYTINVWDVLKGSRVSILFGHENRVSTLRVSP-DGTAFCSGSWDHTLRVW 352 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 44/216 (20%), Positives = 79/216 (36%), Gaps = 15/216 (6%) Query: 209 GKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTR 268 K R L GH V DW + I S+S+D V +WD + N ++ V+ Sbjct: 53 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACA 112 Query: 269 FQPTKGNLLMAISKDKSCRVFDIRYSMKELM-----CVRDETDYMTLEWHPINESMFTLA 323 + P+ G + D C V+ + + E M V T+Y++ ++ A Sbjct: 113 YAPS-GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTA 171 Query: 324 CYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNP--VGHIFATAAKDRTIRFWTR-- 379 DG+ +D+ +L + H + L P G+ F + D+ W Sbjct: 172 SGDGTCALWDVESG---QLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRS 228 Query: 380 ARPIDPNAYDDPTYNNKKI--NGWFFGINNDINAVR 413 + + + N+ + +G F +D R Sbjct: 229 GQCVQAFETHESDVNSVRYYPSGDAFASGSDDATCR 264 >6Q8F-A nrPDB Length = 514 Score = 241 bits (614), Expect = 7e-64, Method: Composition-based stats. Identities = 67/343 (19%), Positives = 146/343 (42%), Gaps = 28/343 (8%) Query: 59 TSYTIDIMPPNAYRGRDRVINLPSKF------THLSSNKVKHVIPAIQWTPEGRRLVVAT 112 M + +RG+ V ++ + H+ + H + +++P+G+ LV + Sbjct: 176 QGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSH-VECARFSPDGQYLVTGS 234 Query: 113 YSGEFSLWNASSFTFETLMQ--------AHDSAVTTMKYSHDSDWMISGDADGMIKIWQP 164 G +WN ++ ++ D AV M +S D++ + +G DG IK+W+ Sbjct: 235 VDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKI 294 Query: 165 NFS-MVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVK 223 ++ + AH++ + ++FS + S+ ++ S D ++I +GK + GH V Sbjct: 295 QSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVN 354 Query: 224 SCDWHPEMGLIASASKDNLVKLWDPRSGNCISSIL------KFKHTVLKTRFQPTKGNLL 277 + + I SAS D VK+W+ ++ C ++ TV P Sbjct: 355 EATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHF 414 Query: 278 MAISKDKSCRVFDIRYSMKELMCV--RDETDYMTLEWHPINESMFTLACYDGSLKHFDLL 335 + ++ + + +++ + R+ D++ P E ++ D L F + Sbjct: 415 VVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIY-CVGEDFVLYCFSTV 473 Query: 336 QNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWT 378 E LT+ H+K + ++++P ++ AT ++D ++ W Sbjct: 474 TGKLERTLTV---HEKDVIGIAHHPHQNLIATYSEDGLLKLWK 513 Score = 122 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 46/296 (15%), Positives = 94/296 (31%), Gaps = 64/296 (21%) Query: 10 QNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPET-----SYTID 64 Q + S ++ + + ++ I + ++++ S + Sbjct: 226 DGQYLVTGSVDGFIEVW-------NFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTE 278 Query: 65 IMPPNAYRGRDRVINLPS-KFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNAS 123 ++ A G+ +V + S + + + ++ + +++ A++ + Sbjct: 279 MLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLK 338 Query: 124 SFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEID------AAHT 177 S + H S V ++ D ++IS +DG +KIW + A Sbjct: 339 SGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTD 398 Query: 178 ESIR---------------------------------------------DMAFSSNDSKF 192 ++ A S Sbjct: 399 ITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWI 458 Query: 193 VTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDP 248 +D +L ++ GK ER L+ H DV HP LIA+ S+D L+KLW P Sbjct: 459 YCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP 514 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 40/234 (17%), Positives = 78/234 (33%), Gaps = 28/234 (11%) Query: 203 IWNFSNGKQERVLSGH-----HWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSI 257 + + K LS H V+ + P+ + + S D +++W+ +G + Sbjct: 194 VKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDL 253 Query: 258 LKF--------KHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMT 309 VL F +L ++D +V+ I+ R + +T Sbjct: 254 KYQAQDNFMMMDDAVLCMCFS-RDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVT 312 Query: 310 LEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAA 369 + S A +D +++ L L H + ++ GH +A+ Sbjct: 313 CLSFSKDSSQILSASFDQTIRIHGLKSG---KTLKEFRGHSSFVNEATFTQDGHYIISAS 369 Query: 370 KDRTIRFWTRA--------RPIDPNAYDDPTYNNKKI---NGWFFGINNDINAV 412 D T++ W + + A D T N+ + N F + N N V Sbjct: 370 SDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTV 423 Score = 67.8 bits (164), Expect = 9e-12, Method: Composition-based stats. Identities = 16/159 (10%), Positives = 50/159 (31%), Gaps = 7/159 (4%) Query: 9 YQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEP-ETSYTIDIMP 67 I S +K + + + + + ++++ P + + Sbjct: 360 QDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVC-- 417 Query: 68 PNAYRGRDRVINLPSKF--THLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSF 125 ++N+ + + S + +P G + ++ + Sbjct: 418 --NRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTG 475 Query: 126 TFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQP 164 E + H+ V + + + + + DG++K+W+P Sbjct: 476 KLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP 514 >5UZ7-B nrPDB Length = 351 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 75/312 (24%), Positives = 124/312 (39%), Gaps = 18/312 (5%) Query: 73 GRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQ 132 GR ++ + HL+ I A+ W + R LV A+ G+ +W++ + + Sbjct: 52 GRIQMRTRRTLRGHLAK------IYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIP 105 Query: 133 AHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSM----VKEIDAAHTESIRDMAFSSN 188 S V T Y+ +++ G D + I+ V A HT + F + Sbjct: 106 LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL-D 164 Query: 189 DSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDP 248 D++ VT S D +W+ G+Q +GH DV S P+ L S + D KLWD Sbjct: 165 DNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV 224 Query: 249 RSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYM 308 R G C + + + F P GN S D +CR+FD+R +ELM + Sbjct: 225 REGMCRQTFTGHESDINAICFFP-NGNAFATGSDDATCRLFDLRAD-QELMTYSHDNIIC 282 Query: 309 TL--EWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFA 366 + + + D + +D L+ +L HD ++ L G A Sbjct: 283 GITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVL---AGHDNRVSCLGVTDDGMAVA 339 Query: 367 TAAKDRTIRFWT 378 T + D ++ W Sbjct: 340 TGSWDSFLKIWN 351 Score = 157 bits (397), Expect = 9e-39, Method: Composition-based stats. Identities = 40/275 (14%), Positives = 96/275 (34%), Gaps = 9/275 (3%) Query: 65 IMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASS 124 ++ + G+ + + + + + + P G + S++N + Sbjct: 80 LLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKT 139 Query: 125 FT----FETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESI 180 + H ++ ++ D + +++ D +W HT + Sbjct: 140 REGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDV 198 Query: 181 RDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKD 240 ++ + + FV+ + D K+W+ G + +GH D+ + + P A+ S D Sbjct: 199 MSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDD 258 Query: 241 NLVKLWDPRSGNCISSILKFKHT--VLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKEL 298 +L+D R+ + + + F G LL+A D +C V+D + + Sbjct: 259 ATCRLFDLRADQELMTYSHDNIICGITSVSFS-KSGRLLLAGYDDFNCNVWDALKADRAG 317 Query: 299 MCVRDETDYMTLEWHPINESMFTLACYDGSLKHFD 333 + + L + +D LK ++ Sbjct: 318 VLAGHDNRVSCLGV-TDDGMAVATGSWDSFLKIWN 351 Score = 122 bits (305), Expect = 4e-28, Method: Composition-based stats. Identities = 48/263 (18%), Positives = 100/263 (38%), Gaps = 18/263 (6%) Query: 160 KIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKF--VTCSDDNILKIWNFSNGKQERVLSG 217 + Q +++ IRD + D+ +T + D + +I + R L G Sbjct: 9 SLLQSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRI----QMRTRRTLRG 64 Query: 218 HHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLL 277 H + + W + L+ SAS+D + +WD + N + +I V+ + P+ GN + Sbjct: 65 HLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS-GNYV 123 Query: 278 MAISKDKSCRVFDIRY---SMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDL 334 D C +++++ +++ + T Y++ ++++ + D + +D+ Sbjct: 124 ACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSGDTTCALWDI 182 Query: 335 LQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPI--DPNAYDDPT 392 T H + SLS P +F + A D + + W + + Sbjct: 183 ETGQQ---TTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESD 239 Query: 393 YNNKKI--NGWFFGINNDINAVR 413 N NG F +D R Sbjct: 240 INAICFFPNGNAFATGSDDATCR 262 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 9/91 (9%), Positives = 28/91 (30%), Gaps = 1/91 (1%) Query: 31 RSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSN 90 R D+ + + Y+ + + + S + ++ V + Sbjct: 262 RLFDLRADQELMTYSHDNIICG-ITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLA 320 Query: 91 KVKHVIPAIQWTPEGRRLVVATYSGEFSLWN 121 + + + T +G + ++ +WN Sbjct: 321 GHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 351 >6F3T-A nrPDB Length = 608 Score = 227 bits (578), Expect = 9e-60, Method: Composition-based stats. Identities = 62/356 (17%), Positives = 123/356 (34%), Gaps = 20/356 (5%) Query: 45 NRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVI-NLPSKFTHLSSNKVKHVIPAIQWTP 103 R LP L ++ IM R R+ + + + A+ T Sbjct: 232 QNRIPLPEL---KDSDKLDKIMNMKETTKRVRLGPDCLPSICFYTFLNAYQGLTAVDVTD 288 Query: 104 EGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ 163 + + +W+ + ++K + D + D + +I Sbjct: 289 DSSLIAGGFADSTVRVWSVTPKKL-----------RSVKQASDLSLIDKESDDVLERIMD 337 Query: 164 PNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVK 223 + +I H+ + +FS + + ++ S+D +++W+ GH++ V Sbjct: 338 EKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVW 397 Query: 224 SCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKD 283 + P S D + +LW + V TRF P N + S D Sbjct: 398 DTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNS-NYVATGSAD 456 Query: 284 KSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPIL 343 ++ R++D+ + + +L + P N DG + +D+ L ++ Sbjct: 457 RTVRLWDVLNGNCVRIFTGHKGPIHSLTFSP-NGRFLATGATDGRVLLWDIGHGL---MV 512 Query: 344 TIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKIN 399 H + SL ++ G I A+ + D T+R W + + DD T IN Sbjct: 513 GELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHIN 568 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 45/221 (20%), Positives = 90/221 (40%), Gaps = 4/221 (1%) Query: 27 VTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTH 86 V +R + ++ + + Y + P+ +Y + ++ G R+ +L + Sbjct: 331 VLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLS----SSEDGTVRLWSLQTFTCL 386 Query: 87 LSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHD 146 + + + Q++P G V + LW + + H + V ++ + Sbjct: 387 VGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPN 446 Query: 147 SDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNF 206 S+++ +G AD +++W I H I + FS N T + D + +W+ Sbjct: 447 SNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDI 506 Query: 207 SNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWD 247 +G L GH V S + + ++AS S DN V+LWD Sbjct: 507 GHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 547 Score = 148 bits (373), Expect = 5e-36, Method: Composition-based stats. Identities = 27/210 (12%), Positives = 70/210 (33%), Gaps = 16/210 (7%) Query: 3 GHNQNQY------QNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVE 56 GH+ Y + S+ ++ + Q + V Y + + + Sbjct: 349 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVG------YKGHNYPVWDTQFS 402 Query: 57 PETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGE 116 P Y + + R+ + ++ P + + Sbjct: 403 PYGYYFVS----GGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRT 458 Query: 117 FSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAH 176 LW+ + + H + ++ +S + ++ +G DG + +W ++ H Sbjct: 459 VRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGH 518 Query: 177 TESIRDMAFSSNDSKFVTCSDDNILKIWNF 206 T+++ + FS + + S DN +++W+ Sbjct: 519 TDTVCSLRFSRDGEILASGSMDNTVRLWDA 548 Score = 114 bits (286), Expect = 7e-26, Method: Composition-based stats. Identities = 34/234 (14%), Positives = 70/234 (29%), Gaps = 40/234 (17%) Query: 214 VLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW--------------------------- 246 + + + D + LIA D+ V++W Sbjct: 273 TFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVL 332 Query: 247 ----DPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVR 302 D ++ + + + V F P + N L++ S+D + R++ ++ + Sbjct: 333 ERIMDEKTASELKILYGHSGPVYGASFSPDR-NYLLSSSEDGTVRLWSLQTFTCLVGYKG 391 Query: 303 DETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVG 362 ++ P F +D + + L I H + ++P Sbjct: 392 HNYPVWDTQFSPYG-YYFVSGGHDRVARLWATDHY---QPLRIFAGHLADVNCTRFHPNS 447 Query: 363 HIFATAAKDRTIRFWTR--ARPIDPNAYDDPTYNNKKI--NGWFFGINNDINAV 412 + AT + DRT+R W + ++ NG F V Sbjct: 448 NYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRV 501 >5G04-R nrPDB Length = 499 Score = 224 bits (570), Expect = 8e-59, Method: Composition-based stats. Identities = 74/396 (18%), Positives = 146/396 (36%), Gaps = 30/396 (7%) Query: 5 NQNQYQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINL--YYNRRHG---LPNLVVEPET 59 +NQ +N + + K + DV I + L V Sbjct: 97 KENQPENSQTPTKKEHQ--KAWALNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQ 154 Query: 60 SYTIDIMPPNAYRGRDRVI-NLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFS 118 T P + R R I +LP + + + + + W+ G L VA Sbjct: 155 KAT-----PGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWS-SGNVLAVAL-DNSVY 207 Query: 119 LWNASSFTFETLMQAHDSA--VTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAH 176 LW+ASS L+Q ++++ + + +++ G + +++W +H Sbjct: 208 LWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSH 267 Query: 177 TESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQE-RVLSGHHWDVKSCDWHPEMGLIA 235 + + +++ N + S + + + LSGH +V W P+ +A Sbjct: 268 SARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLA 325 Query: 236 SASKDNLVKLWDPRSGN----CISSILKFKHTVLKTRFQPTKGNLLMAIS--KDKSCRVF 289 S DNLV +W G + + + + V + P + N+L D+ R++ Sbjct: 326 SGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW 385 Query: 290 DIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAH 349 ++ S L V + ++ W P + + + + + + + + H Sbjct: 386 NV-CSGACLSAVDAHSQVCSILWSPHYKELI--SGHGFAQNQLVIWKYPTMAKVAELKGH 442 Query: 350 DKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDP 385 + SL+ +P G A+AA D T+R W R +DP Sbjct: 443 TSRVLSLTMSPDGATVASAAADETLRLW-RCFELDP 477 >4GGA-A nrPDB Length = 420 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 74/396 (18%), Positives = 146/396 (36%), Gaps = 30/396 (7%) Query: 5 NQNQYQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINL--YYNRRHG---LPNLVVEPET 59 +NQ +N + + K + DV I + L V Sbjct: 18 KENQPENSQTPTKKEHQ--KAWALNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQ 75 Query: 60 SYTIDIMPPNAYRGRDRVI-NLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFS 118 T P + R R I +LP + + + + + W+ G L VA Sbjct: 76 KAT-----PGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWS-SGNVLAVAL-DNSVY 128 Query: 119 LWNASSFTFETLMQAHDSA--VTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAH 176 LW+ASS L+Q ++++ + + +++ G + +++W +H Sbjct: 129 LWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSH 188 Query: 177 TESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQE-RVLSGHHWDVKSCDWHPEMGLIA 235 + + +++ N + S + + + LSGH +V W P+ +A Sbjct: 189 SARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLA 246 Query: 236 SASKDNLVKLWDPRSGN----CISSILKFKHTVLKTRFQPTKGNLLMAIS--KDKSCRVF 289 S DNLV +W G + + + + V + P + N+L D+ R++ Sbjct: 247 SGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW 306 Query: 290 DIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAH 349 ++ S L V + ++ W P + + + + + + + + H Sbjct: 307 NV-CSGACLSAVDAHSQVCSILWSPHYKELI--SGHGFAQNQLVIWKYPTMAKVAELKGH 363 Query: 350 DKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDP 385 + SL+ +P G A+AA D T+R W R +DP Sbjct: 364 TSRVLSLTMSPDGATVASAAADETLRLW-RCFELDP 398 >5GAN-H nrPDB Length = 465 Score = 221 bits (564), Expect = 4e-58, Method: Composition-based stats. Identities = 61/312 (19%), Positives = 117/312 (37%), Gaps = 16/312 (5%) Query: 76 RVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFT-FETLMQAH 134 R+ NL + L S K I A+ + + + +++G+ + N+ + + +H Sbjct: 161 RMANLELAGSQLVSTK---PISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSH 217 Query: 135 DSAVTTMKYSHD-SDWMISGDADGMIKIWQPNFSM----VKEIDAAHTESIRDMAFSSND 189 + + + D ++ MIS DG+IK +Q + + H I D+ + + Sbjct: 218 VGKIGAIDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSG 277 Query: 190 SKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPR 249 + S D ++W+ S ++ + GH V S + + L+ S D+L LWD R Sbjct: 278 KFIGSASHDMTWRLWDASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIR 337 Query: 250 SGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIR--YSMKELMCVRDETDY 307 SG+ + ++ + + P G + D V+DIR + + Sbjct: 338 SGSKVMTLAGHSKPIYTVAWSP-NGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIV 396 Query: 308 MTLEWHP-INESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFA 366 + + YD + + L L H I SL + H Sbjct: 397 TQVRFSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSL---AGHTDKIISLDISNNSHFLV 453 Query: 367 TAAKDRTIRFWT 378 + DR+I+ W Sbjct: 454 SGGWDRSIKLWN 465 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 50/279 (17%), Positives = 112/279 (40%), Gaps = 12/279 (4%) Query: 65 IMPPNAYRGRDRVINLPSKFTHLSSNKVKHV--IPAIQWTPEGR-RLVVATYSGEFSLWN 121 ++ ++ G +V+N + L+ HV I AI W P+ +++ G + Sbjct: 189 VVATGSWAGDLQVLNSQT-LQPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDGLIKNFQ 247 Query: 122 ASSFT----FETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHT 177 S+ + H+ ++ +KY ++ S D ++W + + H Sbjct: 248 YSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHD 307 Query: 178 ESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASA 237 + + ++F + S + D++ +W+ +G + L+GH + + W P +A+ Sbjct: 308 KGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATG 367 Query: 238 SKDNLVKLWDPRSGN--CISSILKFKHTVLKTRFQPTKGN-LLMAISKDKSCRVFDIRYS 294 D ++ +WD R + ++ IL ++ V + RF G L++ D V+ Sbjct: 368 GGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTW 427 Query: 295 MKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFD 333 +K ++L+ N +D S+K ++ Sbjct: 428 LKMGSLAGHTDKIISLDIS-NNSHFLVSGGWDRSIKLWN 465 Score = 124 bits (311), Expect = 8e-29, Method: Composition-based stats. Identities = 40/212 (18%), Positives = 86/212 (40%), Gaps = 11/212 (5%) Query: 177 TESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERV-LSGHHWDVKSCDWHPE-MGLI 234 T+ I ++ S++D T S L++ N + L H + + DWHP+ + Sbjct: 175 TKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQM 234 Query: 235 ASASKDNLVK---LWDPRSG-NCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFD 290 S ++D L+K + G + ++ + + ++ P+ G + + S D + R++D Sbjct: 235 ISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPS-GKFIGSASHDMTWRLWD 293 Query: 291 IRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHD 350 + L+ + +L + + S+ D +D+ + H Sbjct: 294 ASTHQELLLQEGHDKGVFSLSFQC-DGSLVCSGGMDSLSMLWDIRSGSK---VMTLAGHS 349 Query: 351 KCITSLSYNPVGHIFATAAKDRTIRFWTRARP 382 K I +++++P G+ AT D I W + Sbjct: 350 KPIYTVAWSPNGYQVATGGGDGIINVWDIRKR 381 Score = 99.8 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 26/147 (17%), Positives = 60/147 (40%), Gaps = 6/147 (4%) Query: 64 DIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNAS 123 ++ + ++ S ++ I + W+P G ++ G ++W+ Sbjct: 320 SLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIR 379 Query: 124 S---FTFETLMQAHDSAVTTMKYSHD--SDWMISGDADGMIKIWQPNFSMVKEIDAAHTE 178 ++ AH + VT +++S + ++S D +I ++ + + A HT+ Sbjct: 380 KRDEGQLNQIL-AHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSLAGHTD 438 Query: 179 SIRDMAFSSNDSKFVTCSDDNILKIWN 205 I + S+N V+ D +K+WN Sbjct: 439 KIISLDISNNSHFLVSGGWDRSIKLWN 465 >3DM0-A nrPDB Length = 694 Score = 221 bits (563), Expect = 6e-58, Method: Composition-based stats. Identities = 67/338 (19%), Positives = 122/338 (36%), Gaps = 48/338 (14%) Query: 52 NLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVA 111 +++V +I + D+ + + H + + + +G+ + Sbjct: 396 DIIVSASRDKSIIL---WKLTKDDKAYGVAQRRL----TGHSHFVEDVVLSSDGQFALSG 448 Query: 112 TYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKE 171 ++ GE LW+ ++ H V ++ +S D+ ++S D IK+W Sbjct: 449 SWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSASRDRTIKLWNTLGECKYT 508 Query: 172 ID---AAHTESIRDMAFSSNDSK--FVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCD 226 I H + + + FS N + V+ S D +K+WN SN K L+GH V + Sbjct: 509 ISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCKLRSTLAGHTGYVSTVA 568 Query: 227 WHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSC 286 P+ L AS KD +V LWD G + S+ + F P + L A + Sbjct: 569 VSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEA-NSVIHALCFSPNRYWLCAA--TEHGI 625 Query: 287 RVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIP 346 +++D+ D + DL + + P Sbjct: 626 KIWDLES---------------------------KSIVEDLKV---DLKAEAEKADNSGP 655 Query: 347 YAHDKCI---TSLSYNPVGHIFATAAKDRTIRFWTRAR 381 A + + TSL+++ G + D IR W R Sbjct: 656 AATKRKVIYCTSLNWSADGSTLFSGYTDGVIRVWGIGR 693 Score = 154 bits (388), Expect = 1e-37, Method: Composition-based stats. Identities = 42/224 (18%), Positives = 92/224 (41%), Gaps = 14/224 (6%) Query: 168 MVKEIDAAHTESIRDMAFSSND-SKFVTCSDDNILKIWNFSNGKQ-----ERVLSGHHWD 221 ++K AHT+ + +A ++ V+ S D + +W + + +R L+GH Sbjct: 373 VLKGTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHF 432 Query: 222 VKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAIS 281 V+ + S S D ++LWD +G + VL F + ++ S Sbjct: 433 VEDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQI-VSAS 491 Query: 282 KDKSCRVFDIRYSMKELMCVRDETD---YMTLEWHPIN-ESMFTLACYDGSLKHFDLLQN 337 +D++ ++++ K + E + + P + A +D ++K ++L Sbjct: 492 RDRTIKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLS-- 549 Query: 338 LNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRAR 381 N + + H +++++ +P G + A+ KD + W A Sbjct: 550 -NCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAE 592 Score = 96.0 bits (237), Expect = 3e-20, Method: Composition-based stats. Identities = 32/214 (14%), Positives = 71/214 (33%), Gaps = 26/214 (12%) Query: 10 QNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPN 69 N+ + S+ +K + T S R + + P T + Sbjct: 483 DNRQIVSASRDRTIKLWNTLGECKYTISEGGE---GHRDWVSCVRFSPNT--LQPTIVSA 537 Query: 70 AYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFET 129 ++ +V NL + + + + +P+G G LW+ + Sbjct: 538 SWDKTVKVWNLSNCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLY 597 Query: 130 LMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEID---------------- 173 ++A +S + + +S + W+ + G IKIW + E Sbjct: 598 SLEA-NSVIHALCFSPNRYWLCAATEHG-IKIWDLESKSIVEDLKVDLKAEAEKADNSGP 655 Query: 174 AAHTESI---RDMAFSSNDSKFVTCSDDNILKIW 204 AA + + +S++ S + D ++++W Sbjct: 656 AATKRKVIYCTSLNWSADGSTLFSGYTDGVIRVW 689 Score = 56.3 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 16/89 (17%), Positives = 33/89 (37%), Gaps = 3/89 (3%) Query: 300 CVRDETDYMTLEWHPINES-MFTLACYDGSLKHFDLLQNLNEPILTI--PYAHDKCITSL 356 +R TD +T PI+ + + A D S+ + L ++ + H + + Sbjct: 377 TMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDV 436 Query: 357 SYNPVGHIFATAAKDRTIRFWTRARPIDP 385 + G + + D +R W A + Sbjct: 437 VLSSDGQFALSGSWDGELRLWDLAAGVST 465 >5LCW-Q nrPDB Length = 374 Score = 217 bits (553), Expect = 7e-57, Method: Composition-based stats. Identities = 64/328 (19%), Positives = 130/328 (39%), Gaps = 18/328 (5%) Query: 68 PNAYRGRDRVI-NLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFT 126 P + R R I +LP + + + + + W+ G L VA LW+ASS Sbjct: 33 PGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWS-SGNVLAVAL-DNSVYLWSASSGD 90 Query: 127 FETLMQAHDSA--VTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMA 184 L+Q ++++ + + +++ G + +++W +H+ + ++ Sbjct: 91 ILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLS 150 Query: 185 FSSNDSKFVTCSDDNILKIWNFSNGKQE-RVLSGHHWDVKSCDWHPEMGLIASASKDNLV 243 + N + S + + + LSGH +V W P+ +AS DNLV Sbjct: 151 W--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLV 208 Query: 244 KLWDPRSGN----CISSILKFKHTVLKTRFQPTKGNLLMAIS--KDKSCRVFDIRYSMKE 297 +W G + + + + V + P + N+L D+ R++++ S Sbjct: 209 NVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV-CSGAC 267 Query: 298 LMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLS 357 L V + ++ W P + + + + + + + + H + SL+ Sbjct: 268 LSAVDAHSQVCSILWSPHYKELI--SGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLT 325 Query: 358 YNPVGHIFATAAKDRTIRFWTRARPIDP 385 +P G A+AA D T+R W R +DP Sbjct: 326 MSPDGATVASAAADETLRLW-RCFELDP 352 Score = 118 bits (296), Expect = 5e-27, Method: Composition-based stats. Identities = 33/234 (14%), Positives = 81/234 (34%), Gaps = 14/234 (5%) Query: 66 MPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNAS-S 124 + ++ ++ + + + ++ W L + SG + + Sbjct: 116 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVA 173 Query: 125 FTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFS----MVKEIDAAHTESI 180 + H V ++++ D + SG D ++ +W + + H ++ Sbjct: 174 EHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAV 233 Query: 181 RDMAFSS-NDSKFVTCS--DDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASA 237 + +A+ + T D ++IWN +G + H V S W P + S Sbjct: 234 KAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISG 292 Query: 238 S--KDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVF 289 N + +W + ++ + VL P G + + + D++ R++ Sbjct: 293 HGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSP-DGATVASAAADETLRLW 345 >6HQA-B nrPDB Length = 722 Score = 217 bits (552), Expect = 9e-57, Method: Composition-based stats. Identities = 57/313 (18%), Positives = 117/313 (37%), Gaps = 28/313 (8%) Query: 9 YQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPP 68 +N I Q K + + S P + +Y ++ T+ + Sbjct: 353 QDLRNDIAMIQDSRAKI---KLSAAQASLPSVCMYTFHNTNNDLTCLKFNDDSTM--VAS 407 Query: 69 NAYRGRDRVIN-----LPSKFTHLSSNK----------------VKHVIPAIQWTPEGRR 107 ++ + L S + N+ + + ++P+ R Sbjct: 408 GFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGVAVKGSRRLVGHSGAVYGVDFSPDNRY 467 Query: 108 LVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFS 167 L+ + LW+ ++T + H S+V +K+S + + D ++W + Sbjct: 468 LISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKFSPMGHYFATASHDQTARLWSCDHI 527 Query: 168 MVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDW 227 I A H + + F N + T S D ++W+ + G+ RV GH + Sbjct: 528 YPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTARMWDIARGECVRVFMGHSGAINCLAV 587 Query: 228 HPEMGLIASASKDNLVKLWDPRSGNCISSILKFK-HTVLKTRFQPTKGNLLMAISKDKSC 286 P+ +ASA +D++V LWD +G I ++ ++ F +G +L++ D S Sbjct: 588 SPDGRWLASAGEDSVVCLWDISTGRRIKAMRGHGRSSIYSLAFS-REGTVLVSTGADNSV 646 Query: 287 RVFDIRYSMKELM 299 RV+D++ + Sbjct: 647 RVWDVKKNTNSPS 659 Score = 211 bits (538), Expect = 4e-55, Method: Composition-based stats. Identities = 53/303 (17%), Positives = 111/303 (36%), Gaps = 27/303 (8%) Query: 64 DIMPPNAYRGRDRV----INLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSL 119 DI R + ++ +LPS + + + + + +++ + + L Sbjct: 358 DIAMIQDSRAKIKLSAAQASLPSVCMY-TFHNTNNDLTCLKFNDDSTMVASGFQDSFIKL 416 Query: 120 WNASSFTFETLMQ---------------------AHDSAVTTMKYSHDSDWMISGDADGM 158 W+ +L++ H AV + +S D+ ++IS D Sbjct: 417 WSIDGSPLRSLLKNDPYNQQNNDGVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKT 476 Query: 159 IKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGH 218 +++W + H+ S+ D+ FS F T S D ++W+ + R+ +GH Sbjct: 477 VRLWSLDTYTCLVSYKGHSSSVWDVKFSPMGHYFATASHDQTARLWSCDHIYPLRIFAGH 536 Query: 219 HWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLM 278 DV ++HP + + S D ++WD G C+ + + P G L Sbjct: 537 LNDVDCVEFHPNSTYLFTGSSDKTARMWDIARGECVRVFMGHSGAINCLAVSP-DGRWLA 595 Query: 279 AISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNL 338 + +D ++DI + + ++ D S++ +D+ +N Sbjct: 596 SAGEDSVVCLWDISTGRRIKAMRGHGRSSIYSLAFSREGTVLVSTGADNSVRVWDVKKNT 655 Query: 339 NEP 341 N P Sbjct: 656 NSP 658 Score = 198 bits (503), Expect = 5e-51, Method: Composition-based stats. Identities = 53/298 (17%), Positives = 103/298 (34%), Gaps = 27/298 (9%) Query: 125 FTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDA---------- 174 ++ +T +K++ DS + SG D IK+W + S ++ + Sbjct: 380 SVCMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNND 439 Query: 175 -----------AHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVK 223 H+ ++ + FS ++ ++CS+D +++W+ GH V Sbjct: 440 GVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVW 499 Query: 224 SCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKD 283 + P A+AS D +LW + + V F P L S D Sbjct: 500 DVKFSPMGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNS-TYLFTGSSD 558 Query: 284 KSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPIL 343 K+ R++DI + + L P A D + +D+ + Sbjct: 559 KTARMWDIARGECVRVFMGHSGAINCLAVSPDGRW-LASAGEDSVVCLWDISTGRR---I 614 Query: 344 TIPYAH-DKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKING 400 H I SL+++ G + + D ++R W + + + N+ G Sbjct: 615 KAMRGHGRSSIYSLAFSREGTVLVSTGADNSVRVWDVKKNTNSPSAQPEPINDVTAQG 672 Score = 114 bits (285), Expect = 9e-26, Method: Composition-based stats. Identities = 36/228 (15%), Positives = 78/228 (34%), Gaps = 32/228 (14%) Query: 211 QERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSIL------------ 258 + D+ ++ + ++AS +D+ +KLW G+ + S+L Sbjct: 382 CMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSID-GSPLRSLLKNDPYNQQNNDG 440 Query: 259 ----------KFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYM 308 V F P L++ S+DK+ R++ + + + Sbjct: 441 VAVKGSRRLVGHSGAVYGVDFSP-DNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVW 499 Query: 309 TLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATA 368 +++ P+ F A +D + + + L I H + + ++P T Sbjct: 500 DVKFSPMGHY-FATASHDQTARLWSCDHIYP---LRIFAGHLNDVDCVEFHPNSTYLFTG 555 Query: 369 AKDRTIRFWTRARP--IDPNAYDDPTYNNKKI--NGWFFGINNDINAV 412 + D+T R W AR + N + +G + + + V Sbjct: 556 SSDKTARMWDIARGECVRVFMGHSGAINCLAVSPDGRWLASAGEDSVV 603 >5NZU-C nrPDB Length = 905 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 48/253 (18%), Positives = 106/253 (41%), Gaps = 5/253 (1%) Query: 127 FETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFS 186 + + A V ++ WM++ +G + +W + + +R F Sbjct: 7 IKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFV 66 Query: 187 SNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW 246 + + VT +DD ++++N++ ++ + H ++ HP I ++S D L+KLW Sbjct: 67 ARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLW 126 Query: 247 D-PRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDET 305 D + +C H V++ P N + S D++ +V+ + S E Sbjct: 127 DWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEK 186 Query: 306 DYMTLEWHPINESMFTLACYDGSL-KHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHI 364 ++++ + + ++ D L K +D N+ + H + ++ S++P I Sbjct: 187 GVNCIDYYSGGDKPYLISGADDRLVKIWDY---QNKTCVQTLEGHAQNVSCASFHPELPI 243 Query: 365 FATAAKDRTIRFW 377 T ++D T+R W Sbjct: 244 IITGSEDGTVRIW 256 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 50/285 (17%), Positives = 110/285 (38%), Gaps = 7/285 (2%) Query: 93 KHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMIS 152 + ++ P ++ + Y+G +WN + T + D V K+ +W+++ Sbjct: 15 SDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVT 74 Query: 153 GDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFS-NGKQ 211 G D I+++ N + AH++ IR +A +T SDD ++K+W++ Sbjct: 75 GADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSC 134 Query: 212 ERVLSGHHWDVKSCDWHP-EMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTR-F 269 +V GH V +P + ASAS D +K+W S + ++ + V + Sbjct: 135 SQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYY 194 Query: 270 QPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSL 329 L++ + D+ +++D + + +HP + DG++ Sbjct: 195 SGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHP-ELPIIITGSEDGTV 253 Query: 330 KHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTI 374 + + E L + + ++ + A + +I Sbjct: 254 RIWHSSTYRLESTLNYGM---ERVWCVASLRGSNNVALGYDEGSI 295 Score = 174 bits (440), Expect = 9e-44, Method: Composition-based stats. Identities = 45/280 (16%), Positives = 110/280 (39%), Gaps = 6/280 (2%) Query: 54 VVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATY 113 V + T M + Y G V N ++ + + A ++ +V Sbjct: 18 VKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGAD 77 Query: 114 SGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSM-VKEI 172 + ++N ++ + +AH + + ++++ D +IK+W + ++ Sbjct: 78 DMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQV 137 Query: 173 DAAHTESIRDMAFSS-NDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHP-- 229 HT + + + ++++F + S D +K+W + L GH V D++ Sbjct: 138 FEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGG 197 Query: 230 EMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVF 289 + + S + D LVK+WD ++ C+ ++ V F P + +++ S+D + R++ Sbjct: 198 DKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHP-ELPIIITGSEDGTVRIW 256 Query: 290 DIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSL 329 + + + + + + L +GS+ Sbjct: 257 H-SSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSI 295 Score = 138 bits (348), Expect = 4e-33, Method: Composition-based stats. Identities = 29/252 (11%), Positives = 82/252 (32%), Gaps = 11/252 (4%) Query: 169 VKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWH 228 +K A ++ ++ + + + + + +WN + V++ + Sbjct: 7 IKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFV 66 Query: 229 PEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRV 288 + + + D +++++ + + + PT+ +L + S D ++ Sbjct: 67 ARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTS-SDDMLIKL 125 Query: 289 FDI-RYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPY 347 +D + + M + +P + + F A D ++K + L + Sbjct: 126 WDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQL---GSSSPNFTLE 182 Query: 348 AHDKCITSLSYNPVG--HIFATAAKDRTIRFWTRARP--IDPNAYDDPTYNNKKINGWF- 402 H+K + + Y G + A DR ++ W + + + Sbjct: 183 GHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELP 242 Query: 403 -FGINNDINAVR 413 ++ VR Sbjct: 243 IIITGSEDGTVR 254 Score = 127 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 50/399 (12%), Positives = 125/399 (31%), Gaps = 39/399 (9%) Query: 13 NQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYR 72 + + ++ + ++++ + + V P + ++ Sbjct: 71 WVVTGADDMQIRVFNYNTLER------VHMFEAHSDYIRCIAVHPTQ----PFILTSSDD 120 Query: 73 GRDRVINLPSKF-THLSSNKVKHVIPAIQWTP-EGRRLVVATYSGEFSLWNASSFTFETL 130 ++ + K+ H + I P + + A+ +W S + Sbjct: 121 MLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFT 180 Query: 131 MQAHDSAVTTMKYSHDSD--WMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSN 188 ++ H+ V + Y D ++ISG D ++KIW + H +++ +F Sbjct: 181 LEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPE 240 Query: 189 DSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDP 248 +T S+D ++IW+ S + E L+ V +A + + + Sbjct: 241 LPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSI-IVKL 299 Query: 249 RSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDY- 307 S+ + + + NL +I+ + + V+D Sbjct: 300 GREEPAMSMDANGKIIWAKHSEVQQANLKAMGDT-------EIKDGERLPLAVKDMGSCE 352 Query: 308 ---MTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHI 364 T++ +P F + C DG + + N+ + ++ Sbjct: 353 IYPQTIQHNPNG--RFVVVCGDGEYIIYTAMALRNKSFGSAQE--------FAWAHDSSE 402 Query: 365 FATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFF 403 +A + ++ + + P + + I G F Sbjct: 403 YAIRESNSIVKIF---KNFKEKKSFKPDFGAESIYGGFL 438 Score = 74.4 bits (181), Expect = 1e-13, Method: Composition-based stats. Identities = 24/168 (14%), Positives = 52/168 (30%), Gaps = 15/168 (8%) Query: 1 MDGHNQ-------NQYQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNL 53 +GH N N S +K + SSP L G+ + Sbjct: 138 FEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGS-----SSPNFTLE-GHEKGVNCI 191 Query: 54 VVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATY 113 + A ++ + +K + + + PE ++ + Sbjct: 192 DYYSGGDK--PYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSE 249 Query: 114 SGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKI 161 G +W++S++ E+ + V + S+ + G +G I + Sbjct: 250 DGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIV 297 >6ID0-T nrPDB Length = 514 Score = 215 bits (547), Expect = 4e-56, Method: Composition-based stats. Identities = 51/253 (20%), Positives = 102/253 (40%), Gaps = 7/253 (2%) Query: 126 TFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAF 185 ++ H V + + W ++G AD IKIW +K H ++R + Sbjct: 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIV 254 Query: 186 SSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKL 245 S+ +C +D +K W+ K R GH V D HP + ++ + S+D+ ++ Sbjct: 255 STRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314 Query: 246 WDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDET 305 WD R+ + ++ + V R Q + ++ S D + R++D+ + + Sbjct: 315 WDVRTKASVHTLSGHTNAVATVRCQAAEPQII-TGSHDTTIRLWDLVAGKTRVTLTNHKK 373 Query: 306 DYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIF 365 + HP + F D +K + + + + H+ I +L+ N G + Sbjct: 374 SVRAVVLHPRH-YTFASGSPDN-IKQW---KFPDGSFIQNLSGHNAIINTLTVNSDG-VL 427 Query: 366 ATAAKDRTIRFWT 378 + A + T+ W Sbjct: 428 VSGADNGTMHLWD 440 Score = 191 bits (486), Expect = 5e-49, Method: Composition-based stats. Identities = 58/334 (17%), Positives = 112/334 (33%), Gaps = 10/334 (2%) Query: 50 LPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLV 109 + ++V+E + +M A + P K + S + I P + V Sbjct: 162 MNSIVMETGNTKNSALMAKKAPTMPKPQWHPPWKLYRVISG-HLGWVRCIAVEPGNQWFV 220 Query: 110 VATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMV 169 + +W+ +S + + H S V + S S ++ S D +K W ++ V Sbjct: 221 TGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKV 280 Query: 170 KEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHP 229 H ++ + VTCS D+ +IW+ LSGH V + Sbjct: 281 IRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQA 340 Query: 230 EMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVF 289 I + S D ++LWD +G ++ K +V P + S D + + Sbjct: 341 AEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRH-YTFASGSPDN-IKQW 398 Query: 290 DIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAH 349 TL + + +G++ +D N + Sbjct: 399 KFPDGSFIQNLSGHNAIINTLTVNSDG--VLVSGADNGTMHLWDWRTGYNFQRVHAAVQP 456 Query: 350 -----DKCITSLSYNPVGHIFATAAKDRTIRFWT 378 + I + +++ TA D+TI+ + Sbjct: 457 GSLDSESGIFACAFDQSESRLLTAEADKTIKVYR 490 Score = 122 bits (306), Expect = 4e-28, Method: Composition-based stats. Identities = 35/170 (20%), Positives = 61/170 (35%), Gaps = 5/170 (2%) Query: 210 KQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRF 269 K RV+SGH V+ P + S D +K+WD SG S+ TV Sbjct: 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIV 254 Query: 270 QPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSL 329 L + +DK + +D+ Y+ + L+ HP + + D + Sbjct: 255 STRSPYLF-SCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTID-VLVTCSRDSTA 312 Query: 330 KHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTR 379 + +D+ + + H + ++ T + D TIR W Sbjct: 313 RIWDVRTKAS---VHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDL 359 Score = 115 bits (289), Expect = 3e-26, Method: Composition-based stats. Identities = 38/275 (13%), Positives = 91/275 (33%), Gaps = 42/275 (15%) Query: 11 NQNQIQQSQQPPLKKY----------------VTQRRSVDVSSPYI-------------- 40 NQ + S +K + + V SPY+ Sbjct: 216 NQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDL 275 Query: 41 --NLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPA 98 N HG + V + TID++ + R+ ++ +K + + + + + Sbjct: 276 EYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVAT 335 Query: 99 IQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGM 158 ++ +++ ++ LW+ + + H +V + SG D Sbjct: 336 VRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN- 394 Query: 159 IKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGH 218 IK W+ + + H I + +S+ V+ +D+ + +W++ G + + Sbjct: 395 IKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGADNGTMHLWDWRTGYNFQRVHAA 453 Query: 219 --------HWDVKSCDWHPEMGLIASASKDNLVKL 245 + +C + + +A D +K+ Sbjct: 454 VQPGSLDSESGIFACAFDQSESRLLTAEADKTIKV 488 Score = 86.3 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 22/161 (13%), Positives = 50/161 (31%), Gaps = 9/161 (5%) Query: 257 ILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPIN 316 I V +P + S D++ +++D+ +L + + + Sbjct: 200 ISGHLGWVRCIAVEPGNQW-FVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRS 258 Query: 317 ESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRF 376 +F D +K +DL N ++ + H + L +P + T ++D T R Sbjct: 259 PYLF-SCGEDKQVKCWDLEYN---KVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314 Query: 377 WTRARP--IDPNAYDDPTYNNKKINGW--FFGINNDINAVR 413 W + + + + +R Sbjct: 315 WDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIR 355 Score = 58.2 bits (139), Expect = 7e-09, Method: Composition-based stats. Identities = 24/167 (14%), Positives = 56/167 (33%), Gaps = 20/167 (11%) Query: 14 QIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRG 73 I S ++ + V+ N + + +V+ P YT P+ Sbjct: 345 IITGSHDTTIRLWDLVAGKTRVTLT------NHKKSVRAVVLHP-RHYTFASGSPDN--- 394 Query: 74 RDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQA 133 + P + + +I + +G LV +G LW+ + + A Sbjct: 395 -IKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGADNGTMHLWDWRTGYNFQRVHA 452 Query: 134 H--------DSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEI 172 +S + + +++ +AD IK+++ + + +E Sbjct: 453 AVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVYREDDTATEET 499 Score = 51.7 bits (122), Expect = 7e-07, Method: Composition-based stats. Identities = 10/40 (25%), Positives = 17/40 (42%) Query: 341 PILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRA 380 + + H + ++ P F T + DRTI+ W A Sbjct: 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLA 234 >5FL8-q nrPDB Length = 515 Score = 213 bits (543), Expect = 9e-56, Method: Composition-based stats. Identities = 63/385 (16%), Positives = 130/385 (33%), Gaps = 56/385 (14%) Query: 81 PSKFTHLSSNKVKHVIPAIQWTP-EGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVT 139 P + + I + P R+V +W+ + T ++ H + V Sbjct: 131 PVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVL 190 Query: 140 TMKYSHDSDWMISGDADGMIKIWQPNFSMVK-EIDAAHTESIRDMAFSS-------NDSK 191 + +S D + + +G D I++W P + H++ I +++ + + Sbjct: 191 CVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPR 250 Query: 192 FVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRS- 250 + S D +KIW+ + + +SGH V W GL+ S S D V++WD S Sbjct: 251 LASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKW-GGQGLLYSGSHDRTVRVWDINSQ 309 Query: 251 GNCISSILKFKHTVLKTRF--------------------------------------QPT 272 G CI+ + H V Sbjct: 310 GRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGN 369 Query: 273 KGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHF 332 +++ S D + +++ S K + + + + A +D S+K + Sbjct: 370 SEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLW 429 Query: 333 DLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWT-RARPID---PNAY 388 D ++ H + ++++ + + +KD T++ W R R + P Sbjct: 430 DGRDG---KFISTFRGHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDLPGHK 486 Query: 389 DDPTYNNKKINGWFFGINNDINAVR 413 D+ + ++G VR Sbjct: 487 DEVYTVDWSVDGKRVCSGGKDKMVR 511 Score = 208 bits (528), Expect = 6e-54, Method: Composition-based stats. Identities = 59/367 (16%), Positives = 125/367 (34%), Gaps = 55/367 (14%) Query: 61 YTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLW 120 +T M A R+ + ++ + + + + W+P+G + + LW Sbjct: 154 HTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLW 213 Query: 121 NASSFTFET-LMQAHDSAVTTMKYSH-------DSDWMISGDADGMIKIWQPNFSMVKEI 172 + S ++ H +T++ + + S DG IKIW + + Sbjct: 214 DPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYT 273 Query: 173 DAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSN-GKQERVLSGHHWDVKSCDWHPEM 231 + HT S+ + + + S D +++W+ ++ G+ +L H V + Sbjct: 274 MSGHTNSVSCVKW-GGQGLLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSLSTDY 332 Query: 232 GL---------------------------------------IASASKDNLVKLWDP-RSG 251 L + +AS D + LW+P +S Sbjct: 333 ALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKST 392 Query: 252 NCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLE 311 I+ + + V F P G +++ S D S +++D R + Sbjct: 393 KPIARMTGHQKLVNHVAFSP-DGRYIVSASFDNSIKLWDGRDGKFISTFRGHVASVYQVA 451 Query: 312 WHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKD 371 W + + D +LK +D+ + H + ++ ++ G + KD Sbjct: 452 WSS-DCRLLVSCSKDTTLKVWDVRTR---KLSVDLPGHKDEVYTVDWSVDGKRVCSGGKD 507 Query: 372 RTIRFWT 378 + +R WT Sbjct: 508 KMVRLWT 514 Score = 154 bits (388), Expect = 1e-37, Method: Composition-based stats. Identities = 51/252 (20%), Positives = 95/252 (37%), Gaps = 18/252 (7%) Query: 1 MDGHNQNQYQNQN-----QIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVV 55 M GH + + S ++ + ++ IN+ + H + +L + Sbjct: 274 MSGHTNSVSCVKWGGQGLLYSGSHDRTVRVW-----DINSQGRCINILKSHAHWVNHLSL 328 Query: 56 EPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSG 115 + + + A+ + + P + + + + + +V A+ Sbjct: 329 STDYA-----LRIGAFDHTGKKPSTPEEAQKKALENYEKI--CKKNGNSEEMMVTASDDY 381 Query: 116 EFSLWN-ASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDA 174 LWN S M H V + +S D +++S D IK+W Sbjct: 382 TMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGRDGKFISTFR 441 Query: 175 AHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLI 234 H S+ +A+SS+ V+CS D LK+W+ K L GH +V + DW + + Sbjct: 442 GHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDLPGHKDEVYTVDWSVDGKRV 501 Query: 235 ASASKDNLVKLW 246 S KD +V+LW Sbjct: 502 CSGGKDKMVRLW 513 >6MZM-G nrPDB Length = 800 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 47/199 (23%), Positives = 86/199 (43%), Gaps = 1/199 (0%) Query: 92 VKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMI 151 + ++P+ L+ ++ G LW+ +FT + H+ V ++S + + Sbjct: 542 HSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFV 601 Query: 152 SGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQ 211 SG D + ++W + I A H + F N + T S D +++W+ NG Sbjct: 602 SGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNC 661 Query: 212 ERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQP 271 R+ +GH + S + P +A+ + D V LWD G + + TV RF Sbjct: 662 VRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS- 720 Query: 272 TKGNLLMAISKDKSCRVFD 290 G +L + S D + R++D Sbjct: 721 RDGEILASGSMDNTVRLWD 739 Score = 209 bits (531), Expect = 3e-54, Method: Composition-based stats. Identities = 47/224 (20%), Positives = 88/224 (39%), Gaps = 5/224 (2%) Query: 129 TLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSN 188 ++ H V +S D ++++S DG +++W H + D FS Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 596 Query: 189 DSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDP 248 FV+ D + ++W + + R+ +GH DV +HP +A+ S D V+LWD Sbjct: 597 GYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDV 656 Query: 249 RSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYM 308 +GNC+ K + F P G L + D ++DI + + Sbjct: 657 LNGNCVRIFTGHKGPIHSLTFSP-NGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC 715 Query: 309 TLEWHPINESMFTLACYDGSLKHFDLLQNLNEPI---LTIPYAH 349 +L + E + D +++ +D ++ + T H Sbjct: 716 SLRFSRDGE-ILASGSMDNTVRLWDAIKAFEDLETDDFTTATGH 758 Score = 208 bits (528), Expect = 5e-54, Method: Composition-based stats. Identities = 47/229 (20%), Positives = 89/229 (38%), Gaps = 5/229 (2%) Query: 171 EIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPE 230 +I H+ + +FS + + ++ S+D +++W+ GH++ V + P Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 596 Query: 231 MGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFD 290 S D + +LW + V TRF P N + S D++ R++D Sbjct: 597 GYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNS-NYVATGSADRTVRLWD 655 Query: 291 IRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHD 350 + + + +L + P N DG + +D+ L ++ H Sbjct: 656 VLNGNCVRIFTGHKGPIHSLTFSP-NGRFLATGATDGRVLLWDIGHGL---MVGELKGHT 711 Query: 351 KCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKIN 399 + SL ++ G I A+ + D T+R W + + DD T IN Sbjct: 712 DTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHIN 760 Score = 183 bits (464), Expect = 2e-46, Method: Composition-based stats. Identities = 43/204 (21%), Positives = 82/204 (40%), Gaps = 4/204 (1%) Query: 44 YNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTP 103 Y + P+ +Y + ++ G R+ +L + + + + Q++P Sbjct: 540 YGHSGPVYGASFSPDRNYLLS----SSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSP 595 Query: 104 EGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ 163 G V + LW + + H + V ++ +S+++ +G AD +++W Sbjct: 596 YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD 655 Query: 164 PNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVK 223 I H I + FS N T + D + +W+ +G L GH V Sbjct: 656 VLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC 715 Query: 224 SCDWHPEMGLIASASKDNLVKLWD 247 S + + ++AS S DN V+LWD Sbjct: 716 SLRFSRDGEILASGSMDNTVRLWD 739 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 27/210 (12%), Positives = 70/210 (33%), Gaps = 16/210 (7%) Query: 3 GHNQNQY------QNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVE 56 GH+ Y + S+ ++ + Q + V Y + + + Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVG------YKGHNYPVWDTQFS 594 Query: 57 PETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGE 116 P Y + + R+ + ++ P + + Sbjct: 595 PYGYYFVS----GGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRT 650 Query: 117 FSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAH 176 LW+ + + H + ++ +S + ++ +G DG + +W ++ H Sbjct: 651 VRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGH 710 Query: 177 TESIRDMAFSSNDSKFVTCSDDNILKIWNF 206 T+++ + FS + + S DN +++W+ Sbjct: 711 TDTVCSLRFSRDGEILASGSMDNTVRLWDA 740 Score = 50.5 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 12/74 (16%), Positives = 29/74 (39%), Gaps = 4/74 (5%) Query: 344 TIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRA--RPIDPNAYDDPTYNNKKIN-- 399 I Y H + S++P + ++++D T+R W+ + + + + + Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 596 Query: 400 GWFFGINNDINAVR 413 G++F R Sbjct: 597 GYYFVSGGHDRVAR 610 >3FM0-A nrPDB Length = 345 Score = 212 bits (539), Expect = 3e-55, Method: Composition-based stats. Identities = 67/317 (21%), Positives = 121/317 (38%), Gaps = 35/317 (11%) Query: 99 IQWTPEGRRLVVATYSGEFSLWNASSFTFE---TLMQAHDSAVTTMKYSHDSDWMISGDA 155 + W P G L +W ++ L + H V + +S +++ S Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81 Query: 156 DGMIKIWQPNFS--MVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNG---K 210 D IW+ N H ++ +A++ + + TCS D + +W + Sbjct: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYE 141 Query: 211 QERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGN--CISSILKFKHTVLKTR 268 VL+ H DVK WHP L+ASAS D+ VKL+ + C +++ + TV Sbjct: 142 CVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLA 201 Query: 269 FQPTKGNLLMAISKDKSCRVF----------------DIRYSMKELMCVRDETDYMTLEW 312 F P+ G L + S D++ R++ D + + + W Sbjct: 202 FDPS-GQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAW 260 Query: 313 HPINESMFTLACYDGSLKHF------DLLQNLNEPILTIPYAHDKCITSLSYNP-VGHIF 365 + + AC D +++ F D Q + AH + + +++NP + Sbjct: 261 CQLTGA-LATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLL 319 Query: 366 ATAAKDRTIRFWTRARP 382 A+ + D + FW RP Sbjct: 320 ASCSDDGEVAFWKYQRP 336 Score = 170 bits (431), Expect = 1e-42, Method: Composition-based stats. Identities = 50/303 (16%), Positives = 106/303 (34%), Gaps = 36/303 (11%) Query: 65 IMPPNAYRGRDRVINLPSK---FTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLW- 120 ++ R R+ + S + + + W+P G L A++ +W Sbjct: 30 LLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWK 89 Query: 121 -NASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQP---NFSMVKEIDAAH 176 N F T ++ H++ V ++ ++ + + + D + +W+ + + +H Sbjct: 90 KNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSH 149 Query: 177 TESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGK--QERVLSGHHWDVKSCDWHPEMGLI 234 T+ ++ + + + + S D+ +K++ L GH V S + P + Sbjct: 150 TQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRL 209 Query: 235 ASASKDNLVKLWD---------------PRSGNCISSILK-FKHTVLKTRFQPTKGNLLM 278 AS S D V++W S CI ++ T+ + G L Sbjct: 210 ASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALAT 269 Query: 279 AISKDKSCRVF---------DIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSL 329 A D + RVF +S+ + D + W+P + DG + Sbjct: 270 ACGDD-AIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEV 328 Query: 330 KHF 332 + Sbjct: 329 AFW 331 Score = 117 bits (293), Expect = 1e-26, Method: Composition-based stats. Identities = 36/202 (17%), Positives = 77/202 (38%), Gaps = 13/202 (6%) Query: 223 KSCDWHPEMGLIASASKDNLVKLWDPR--SGNCISSI-LKFKHTVLKTRFQPTKGNLLMA 279 W+P L+AS D +++W S C S + + TV K + P GN L + Sbjct: 20 WFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSP-CGNYLAS 78 Query: 280 ISKDKSCRVFDIRYSMKELMCV--RDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQN 337 S D + ++ E + E + ++ W P + D S+ +++ + Sbjct: 79 ASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGN-LLATCSRDKSVWVWEVDEE 137 Query: 338 LNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARP----IDPNAYDDPTY 393 +++ +H + + + ++P + A+A+ D T++ + + T Sbjct: 138 DEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTV 197 Query: 394 NNKKIN--GWFFGINNDINAVR 413 + + G +D VR Sbjct: 198 WSLAFDPSGQRLASCSDDRTVR 219 Score = 112 bits (279), Expect = 4e-25, Method: Composition-based stats. Identities = 41/282 (14%), Positives = 91/282 (32%), Gaps = 45/282 (15%) Query: 2 DGHNQNQYQNQN------QIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVV 55 +GH + + S + + + + + + ++ Sbjct: 58 EGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFEC----VTTLEGHENEVKSVAW 113 Query: 56 EPETSYTIDIMPPNAYRGRDRVINLPSKFTHL---SSNKVKHVIPAIQWTPEGRRLVVAT 112 P + + V + + + N + + W P L A+ Sbjct: 114 APSGNLLATC----SRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASAS 169 Query: 113 YSGEFSLWNASSFTFE--TLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIW-------- 162 Y L+ + ++ H+S V ++ + + S D ++IW Sbjct: 170 YDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNE 229 Query: 163 --------QPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIW--NFSNGKQE 212 P++ + + H+ +I D+A+ T D+ ++++ + ++ Q+ Sbjct: 230 QGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQ 289 Query: 213 RVLS-------GHHWDVKSCDWHPEM-GLIASASKDNLVKLW 246 S H DV W+P+ GL+AS S D V W Sbjct: 290 PTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFW 331 Score = 82.9 bits (203), Expect = 3e-16, Method: Composition-based stats. Identities = 27/244 (11%), Positives = 79/244 (32%), Gaps = 41/244 (16%) Query: 1 MDGHNQNQYQNQN------QIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLV 54 ++GH S+ + + +++ + + ++V Sbjct: 101 LEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEED---EYECVSVLNSHTQDVKHVV 157 Query: 55 VEPETSYTIDIMPPNAYRGRDRVINLPSK--FTHLSSNKVKHVIPAIQWTPEGRRLVVAT 112 P +++ +Y ++ + + + ++ + P G+RL + Sbjct: 158 WHPSQ----ELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCS 213 Query: 113 YSGEFSLW---------------NASSFTFETLMQA-HDSAVTTMKYSHDSDWMISGDAD 156 +W + S+ + H + + + + + + D Sbjct: 214 DDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGD 273 Query: 157 GMIKIWQ---------PNFSMVKEIDAAHTESIRDMAFSSND-SKFVTCSDDNILKIWNF 206 I+++Q P FS+ + AH++ + +A++ + +CSDD + W + Sbjct: 274 DAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKY 333 Query: 207 SNGK 210 + Sbjct: 334 QRPE 337 Score = 40.5 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 12/34 (35%), Positives = 17/34 (50%) Query: 344 TIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 +P D L++NP G + A+ DR IR W Sbjct: 10 RVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIW 43 >6QX9-5O nrPDB Length = 357 Score = 211 bits (537), Expect = 5e-55, Method: Composition-based stats. Identities = 62/355 (17%), Positives = 123/355 (34%), Gaps = 30/355 (8%) Query: 45 NRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHV--------- 95 R+ LV + + ++ + G + P + + Sbjct: 6 KRKGPELPLVPVKRQRHEL-LLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIMLLSG 64 Query: 96 ----IPAIQWTPEGRRLVVATYSGEFSLWNA-SSFTFETLMQAHDSAVTTMKYSHDSDWM 150 + ++ P G L A + LWN ++ H AV + Y+ D + Sbjct: 65 HEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSML 124 Query: 151 ISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFV-TCSDDNILKIWNFSNG 209 S D + +W + HT + + + V T SDD +K+W+ Sbjct: 125 FSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKK 184 Query: 210 KQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRF 269 + + V + ++ I S DN +K+WD R ++ +V Sbjct: 185 AAIQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSL 243 Query: 270 QPTKGNLLMAISKDKSCRVFDIRYSMKELMCV--------RDETDYMTLEWHPINESMFT 321 ++G+ L++ + D + RV+D+R + CV E + + W P + S Sbjct: 244 S-SEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSP-DGSKIA 301 Query: 322 LACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRF 376 D + +D + IL H I ++++P I +A+ D+ + Sbjct: 302 AGSADRFVYVWDT---TSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYM 353 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 58/279 (20%), Positives = 109/279 (39%), Gaps = 12/279 (4%) Query: 130 LMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKE-IDAAHTESIRDMAFSSN 188 L+ H+ V K+ + + S D +I +W H+ ++ ++ ++++ Sbjct: 61 LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTD 120 Query: 189 DSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSC-DWHPEMGLIASASKDNLVKLWD 247 S + S D + +W+ G++ + L GH V SC L+ + S D VKLWD Sbjct: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180 Query: 248 PRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDY 307 R I + + VL F T ++ + D +V+D+R + K +R D Sbjct: 181 IRKKAAIQTFQN-TYQVLAVTFNDTSDQII-SGGIDNDIKVWDLRQN-KLTYTMRGHADS 237 Query: 308 MTLEWHPINESMFTLACYDGSLKHFDLLQ-NLNEPILTIPYA--H--DKCITSLSYNPVG 362 +T S D +++ +D+ E + I H +K + S++P G Sbjct: 238 VTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDG 297 Query: 363 HIFATAAKDRTIRFWTRA--RPIDPNAYDDPTYNNKKIN 399 A + DR + W R + + N + Sbjct: 298 SKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFH 336 Score = 156 bits (395), Expect = 2e-38, Method: Composition-based stats. Identities = 46/259 (17%), Positives = 99/259 (38%), Gaps = 11/259 (4%) Query: 43 YYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWT 102 Y G V+E + ++ + V + + + + Sbjct: 101 NYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPA 160 Query: 103 PEG-RRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKI 161 G + + + G LW+ Q V + ++ SD +ISG D IK+ Sbjct: 161 RRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIKV 219 Query: 162 WQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFS----NGKQERVLSG 217 W + + H +S+ ++ SS S ++ + DN +++W+ + ++ G Sbjct: 220 WDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQG 279 Query: 218 H----HWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTK 273 + ++ C W P+ IA+ S D V +WD S + + ++ + F P + Sbjct: 280 NVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDE 339 Query: 274 GNLLMAISKDKSCRVFDIR 292 ++++ S DK + +I+ Sbjct: 340 P-IIISASSDKRLYMGEIQ 357 Score = 135 bits (339), Expect = 4e-32, Method: Composition-based stats. Identities = 41/259 (15%), Positives = 94/259 (36%), Gaps = 32/259 (12%) Query: 1 MDGHNQN------QYQNQNQIQQSQQPPLKKYVTQRRSVDVS----SPYINLYYNRRHGL 50 + GH+ S + + ++ + ++N Y R G Sbjct: 105 LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRG- 163 Query: 51 PNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVV 110 P LV + G ++ ++ K + + + + + A+ + +++ Sbjct: 164 PQLVCT------------GSDDGTVKLWDIRKKAA-IQTFQNTYQVLAVTFNDTSDQIIS 210 Query: 111 ATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVK 170 + +W+ M+ H +VT + S + +++S D +++W K Sbjct: 211 GGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPK 270 Query: 171 E----IDAAHTE----SIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDV 222 E I + ++ ++S + SK S D + +W+ ++ + L GH + Sbjct: 271 ERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSI 330 Query: 223 KSCDWHPEMGLIASASKDN 241 +HP+ +I SAS D Sbjct: 331 NEVAFHPDEPIIISASSDK 349 Score = 105 bits (261), Expect = 5e-23, Method: Composition-based stats. Identities = 30/200 (15%), Positives = 63/200 (31%), Gaps = 19/200 (9%) Query: 12 QNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAY 71 Q S +K + D+ + + V+ + T D + Sbjct: 165 QLVCTGSDDGTVKLW-------DIRKKAAIQTFQNTYQ----VLAVTFNDTSDQIISGGI 213 Query: 72 RGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFT----F 127 +V +L + + + + EG L+ +W+ F Sbjct: 214 DNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERC 273 Query: 128 ETLMQA--HD--SAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDM 183 + Q H+ + +S D + +G AD + +W + H SI ++ Sbjct: 274 VKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEV 333 Query: 184 AFSSNDSKFVTCSDDNILKI 203 AF ++ ++ S D L + Sbjct: 334 AFHPDEPIIISASSDKRLYM 353 >4V7E-Bg nrPDB Length = 380 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 62/308 (20%), Positives = 119/308 (38%), Gaps = 23/308 (7%) Query: 92 VKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMI 151 + ++ WTPE +V A+ G +WNA + ++ H V ++ + + Sbjct: 65 HSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWVMECAFAPNGQSVA 124 Query: 152 SGDADGMIKIWQPNFSM-------VKEIDAAHTESIRDMAFSSND-SKFVTCSDDNILKI 203 G D I+ + V + H + + ++ +T S D + Sbjct: 125 CGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSGDQTCVL 184 Query: 204 WNFSNGKQERVL-----SGHHWDVKSCDWHP-EMGLIASASKDNLVKLWDPR-SGNCISS 256 W+ + G++ + SGH DV S + + S S D V+LWD R + + + Sbjct: 185 WDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRITSRAVRT 244 Query: 257 ILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYS------MKELMCVRDETDYMTL 310 + + +F P G S D +CR+FD+R +E +E +T Sbjct: 245 YHGHEGDINSVKFFP-DGQRFGTGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVTS 303 Query: 311 EWHPINESMFTLACYDGSLKHFD-LLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAA 369 I+ + +G +D LL + + T+ +H+ I+ L + G T + Sbjct: 304 VAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQNSHEGRISCLGLSSDGSALCTGS 363 Query: 370 KDRTIRFW 377 D+ ++ W Sbjct: 364 WDKNLKIW 371 Score = 149 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 49/235 (20%), Positives = 89/235 (37%), Gaps = 16/235 (6%) Query: 194 TCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNC 253 + + +N ++ R L GH V S DW PE I SAS+D + +W+ + Sbjct: 41 SKAQGRTAVSFNPTDLVCCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQK 100 Query: 254 ISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSM-------KELMCVRDETD 306 +I V++ F P G + D +C +F++ + + Sbjct: 101 THAIKLHCPWVMECAFAP-NGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGY 159 Query: 307 YMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPIL--TIPYAHDKCITSLSYNPVG-H 363 + ++ P E+ D + +D+ I P H + SLS N + + Sbjct: 160 ASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNAN 219 Query: 364 IFATAAKDRTIRFWT---RARPIDPNAYDDPTYNNKKI--NGWFFGINNDINAVR 413 +F + + D T+R W +R + + N+ K +G FG +D R Sbjct: 220 MFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCR 274 Score = 147 bits (370), Expect = 1e-35, Method: Composition-based stats. Identities = 56/293 (19%), Positives = 104/293 (35%), Gaps = 28/293 (9%) Query: 66 MPPNAYRGRDRVIN-LPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASS 124 + + GR V N L S+ TH V+ + P G+ + S++N SS Sbjct: 81 IVSASQDGRLIVWNALTSQKTHAIKLHCPWVMEC-AFAPNGQSVACGGLDSACSIFNLSS 139 Query: 125 FT-------FETLMQAHDSAVTTMKYSHDS-DWMISGDADGMIKIWQPNFSMVKEIDA-- 174 ++ H ++ +Y D +I+G D +W I Sbjct: 140 QADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSE 199 Query: 175 ---AHTESIRDMAFSS-NDSKFVTCSDDNILKIWNFS-NGKQERVLSGHHWDVKSCDWHP 229 HT + ++ +S N + F++ S D +++W+ + R GH D+ S + P Sbjct: 200 FPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINSVKFFP 259 Query: 230 EMGLIASASKDNLVKLWDPRSGNCISSILKFKH-------TVLKTRFQPTKGNLLMAISK 282 + + S D +L+D R+G+ + + V F G LL A Sbjct: 260 DGQRFGTGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVTSVAFS-ISGRLLFAGYS 318 Query: 283 DKSCRVFDI---RYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHF 332 + C V+D + ++ + S +D +LK + Sbjct: 319 NGDCYVWDTLLAEMVLNLGTLQNSHEGRISCLGLSSDGSALCTGSWDKNLKIW 371 Score = 128 bits (322), Expect = 4e-30, Method: Composition-based stats. Identities = 49/330 (14%), Positives = 106/330 (32%), Gaps = 43/330 (13%) Query: 1 MDGHNQNQY------QNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLV 54 + GH+ Y + + SQ L + + I L + Sbjct: 62 LQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQ---KTHAIKL---HCPWVMECA 115 Query: 55 VEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLS-------SNKVKHVIPAIQWTPEGR- 106 P ++ + NL S+ K + Q+ P+ Sbjct: 116 FAPN-GQSVAC---GGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQET 171 Query: 107 RLVVATYSGEFSLWNASSFTFETLM-----QAHDSAVTTMKYSH-DSDWMISGDADGMIK 160 RL+ + LW+ ++ ++ H + V ++ + +++ ISG D ++ Sbjct: 172 RLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVR 231 Query: 161 IWQPN-FSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHH 219 +W S H I + F + +F T SDD ++++ G Q +V + Sbjct: 232 LWDLRITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNREP 291 Query: 220 WD-------VKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSI----LKFKHTVLKTR 268 V S + L+ + + +WD + ++ + + Sbjct: 292 DRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQNSHEGRISCLG 351 Query: 269 FQPTKGNLLMAISKDKSCRVFDIRYSMKEL 298 + G+ L S DK+ +++ K + Sbjct: 352 LS-SDGSALCTGSWDKNLKIWAFSGHRKIV 380 >4V6W-Ag nrPDB Length = 318 Score = 207 bits (527), Expect = 7e-54, Method: Composition-based stats. Identities = 59/294 (20%), Positives = 116/294 (39%), Gaps = 22/294 (7%) Query: 51 PNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVV 110 P+ ++ T+ + R D P K + H I + + +G + Sbjct: 28 PDTIISASRDKTL--IVWKLTRDEDTNYGYPQKRLY----GHSHFISDVVLSSDGNYALS 81 Query: 111 ATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVK 170 ++ LW+ ++ + H V ++ +S D+ ++SG D IK+W Sbjct: 82 GSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTLAECKF 141 Query: 171 EIDA-AHTESIRDMAFSSNDS--KFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDW 227 I HT+ + + FS N S V+C D +K+WN +N K + GH+ + + Sbjct: 142 TIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCKLKNNHHGHNGYLNTVTV 201 Query: 228 HPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCR 287 P+ L S KD+ LWD G + ++ + F P + L +A S + Sbjct: 202 SPDGSLCTSGGKDSKALLWDLNDGKNLYTLE-HNDIINALCFSPNRYWLCVAYGP--SIK 258 Query: 288 VFD---------IRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHF 332 ++D +R + D+ ++L W +++F D +++ + Sbjct: 259 IWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTLFA-GYSDNTIRVW 311 Score = 194 bits (492), Expect = 9e-50, Method: Composition-based stats. Identities = 58/307 (18%), Positives = 110/307 (35%), Gaps = 20/307 (6%) Query: 90 NKVKHVIPAIQWTP-EGRRLVVATYSGEFSLW------NASSFTFETLMQAHDSAVTTMK 142 + I P + ++ A+ +W + + + + H ++ + Sbjct: 12 IGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDVV 71 Query: 143 YSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILK 202 S D ++ +SG D +++W HT+ + +AFS+++ + V+ S D +K Sbjct: 72 LSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQIVSGSRDKTIK 131 Query: 203 IWN-FSNGKQERVLSGHHWDVKSCDWHPEMG--LIASASKDNLVKLWDPRSGNCISSILK 259 +WN + K GH V + P +I S D VK+W+ + ++ Sbjct: 132 LWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCKLKNNHHG 191 Query: 260 FKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESM 319 + P G+L + KD ++D+ K L + L + P Sbjct: 192 HNGYLNTVTVSP-DGSLCTSGGKDSKALLWDLN-DGKNLYTLEHNDIINALCFSP--NRY 247 Query: 320 FTLACYDGSLKHFDLLQNLNEPILT------IPYAHDKCITSLSYNPVGHIFATAAKDRT 373 + Y S+K +DL L A SL+++ G D T Sbjct: 248 WLCVAYGPSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTLFAGYSDNT 307 Query: 374 IRFWTRA 380 IR W + Sbjct: 308 IRVWQVS 314 Score = 181 bits (460), Expect = 4e-46, Method: Composition-based stats. Identities = 60/269 (22%), Positives = 110/269 (40%), Gaps = 17/269 (6%) Query: 122 ASSFTFETLMQAHDSAVTTMKYSH-DSDWMISGDADGMIKIW------QPNFSMVKEIDA 174 + + + H+ VT + + D D +IS D + +W N+ ++ Sbjct: 2 SETLQLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLY 61 Query: 175 AHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLI 234 H+ I D+ SS+ + ++ S D L++W+ + GK R GH DV S + + I Sbjct: 62 GHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQI 121 Query: 235 ASASKDNLVKLWDPRSGNCISSIL--KFKHTVLKTRFQPTKGN-LLMAISKDKSCRVFDI 291 S S+D +KLW+ C +I V RF P N ++++ D++ +V+++ Sbjct: 122 VSGSRDKTIKLWNTL-AECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNL 180 Query: 292 RYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDK 351 + T+ P + S+ T D +DL N L H+ Sbjct: 181 ANCKLKNNHHGHNGYLNTVTVSP-DGSLCTSGGKDSKALLWDLNDGKNLYTLE----HND 235 Query: 352 CITSLSYNPVGHIFATAAKDRTIRFWTRA 380 I +L ++P + A +I+ W A Sbjct: 236 IINALCFSPN-RYWLCVAYGPSIKIWDLA 263 Score = 115 bits (289), Expect = 3e-26, Method: Composition-based stats. Identities = 34/204 (16%), Positives = 74/204 (36%), Gaps = 15/204 (7%) Query: 207 SNGKQERVLSGHHWDVKSCDWHP-EMGLIASASKDNLVKLW------DPRSGNCISSILK 259 + L GH+ V +P + I SAS+D + +W D G + Sbjct: 3 ETLQLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYG 62 Query: 260 FKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESM 319 H + + GN ++ S D++ R++D+ D +++ + + Sbjct: 63 HSHFISDVVLS-SDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFS-ADNRQ 120 Query: 320 FTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPV--GHIFATAAKDRTIRFW 377 D ++K ++ L I H ++ + ++P I + DRT++ W Sbjct: 121 IVSGSRDKTIKLWNTLAECKFTIQE--DGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVW 178 Query: 378 TRA--RPIDPNAYDDPTYNNKKIN 399 A + + + + N ++ Sbjct: 179 NLANCKLKNNHHGHNGYLNTVTVS 202 Score = 85.2 bits (209), Expect = 6e-17, Method: Composition-based stats. Identities = 30/222 (13%), Positives = 72/222 (32%), Gaps = 24/222 (10%) Query: 1 MDGHNQN------QYQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLV 54 +GH ++ N+ + S+ +K + T + + + Sbjct: 102 FEGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTLAECK-----FTIQEDGHTDWVSCVR 156 Query: 55 VEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYS 114 P ++ I+ + +V NL + + + + + +P+G Sbjct: 157 FSPN--HSNPIIVSCGWDRTVKVWNLANCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKD 214 Query: 115 GEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPN--------- 165 + LW+ + ++ H+ + + +S + W+ IKIW Sbjct: 215 SKALLWDLNDGKNLYTLE-HNDIINALCFSPNRYWLCVA-YGPSIKIWDLACKKTVEELR 272 Query: 166 FSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFS 207 +V A +A+S++ DN +++W S Sbjct: 273 PEVVSPTSKADQPQCLSLAWSTDGQTLFAGYSDNTIRVWQVS 314 Score = 65.9 bits (159), Expect = 3e-11, Method: Composition-based stats. Identities = 26/170 (15%), Positives = 60/170 (35%), Gaps = 21/170 (12%) Query: 9 YQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPP 68 + N + +K + + N ++ L + V P+ S + Sbjct: 161 HSNPIIVSCGWDRTVKVWNLANCKLK------NNHHGHNGYLNTVTVSPDGS----LCTS 210 Query: 69 NAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNAS----- 123 + + +L + +L + + +I A+ ++P L VA Y +W+ + Sbjct: 211 GGKDSKALLWDL-NDGKNLYTLEHNDIINALCFSPNRYWLCVA-YGPSIKIWDLACKKTV 268 Query: 124 ----SFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMV 169 +A ++ +S D + +G +D I++WQ + S Sbjct: 269 EELRPEVVSPTSKADQPQCLSLAWSTDGQTLFAGYSDNTIRVWQVSVSAH 318 >4N14-A nrPDB Length = 314 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 60/316 (18%), Positives = 125/316 (39%), Gaps = 17/316 (5%) Query: 79 NLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSA- 137 +LP + + + + + W+ G L VA LW+ASS L+Q Sbjct: 7 SLPDRILDAPEIRNDYYLNLVDWS-SGNVLAVAL-DNSVYLWSASSGDILQLLQMEQPGE 64 Query: 138 -VTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCS 196 ++++ + + +++ G + +++W +H+ + +++ N + S Sbjct: 65 YISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGS 122 Query: 197 DDNILKIWNFSNGKQE-RVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGN--- 252 + + + LSGH +V W P+ +AS DNLV +W G Sbjct: 123 RSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGW 182 Query: 253 -CISSILKFKHTVLKTRFQPTKGNLLMAIS--KDKSCRVFDIRYSMKELMCVRDETDYMT 309 + + + + V + P + N+L D+ R++++ S L V + + Sbjct: 183 VPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNV-CSGACLSAVDAHSQVCS 241 Query: 310 LEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAA 369 + W P + + + + + + + + H + SL+ +P G A+AA Sbjct: 242 ILWSPHYKELI--SGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAA 299 Query: 370 KDRTIRFWTRARPIDP 385 D T+R W R +DP Sbjct: 300 ADETLRLW-RCFELDP 314 Score = 115 bits (289), Expect = 3e-26, Method: Composition-based stats. Identities = 33/234 (14%), Positives = 81/234 (34%), Gaps = 14/234 (5%) Query: 66 MPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNAS-S 124 + ++ ++ + + + ++ W L + SG + + Sbjct: 78 LAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSY--ILSSGSRSGHIHHHDVRVA 135 Query: 125 FTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFS----MVKEIDAAHTESI 180 + H V ++++ D + SG D ++ +W + + H ++ Sbjct: 136 EHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAV 195 Query: 181 RDMAFSS-NDSKFVTCS--DDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASA 237 + +A+ + T D ++IWN +G + H V S W P + S Sbjct: 196 KAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISG 254 Query: 238 S--KDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVF 289 N + +W + ++ + VL P G + + + D++ R++ Sbjct: 255 HGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSP-DGATVASAAADETLRLW 307 >5OPT-p nrPDB Length = 318 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 60/291 (20%), Positives = 116/291 (39%), Gaps = 22/291 (7%) Query: 108 LVVATYSGEFSLWNA---------SSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGM 158 V + W + E ++ H + V+ + S++ D+ +S D Sbjct: 31 AVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAFVSDVALSNNGDFAVSASWDHS 90 Query: 159 IKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSG- 217 +++W + + HT+ + + FS ++ + V+ DN L++WN + G Sbjct: 91 LRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQIVSGGRDNALRVWNVKGECLHTLGRGA 150 Query: 218 HHWDVKSCDWHP--EMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGN 275 H V + P E LI S DNLVK+WD SG ++ + + + P G+ Sbjct: 151 HTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASGRLLTDLKGHTNYITSVTVSP-DGS 209 Query: 276 LLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLL 335 L + KD R++D+ + L + + + P + A + ++ FDL Sbjct: 210 LCASSDKDGVARLWDL-TKGEALSEMAAGAPINQICFSP--NRYWMCAATEKGIRIFDLE 266 Query: 336 QNLNEPILTIPYAHDKC-----ITSLSYNPVGHIFATAAKDRTIRFWTRAR 381 N + + P A K S++++ G+ + D IR W+ + Sbjct: 267 -NKDVIVELAPEAQQKSKKTPECMSIAWSADGNTLYSGYTDNVIRVWSVSE 316 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 50/254 (19%), Positives = 106/254 (41%), Gaps = 14/254 (5%) Query: 92 VKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMI 151 + + + G V A++ LWN + + H V ++ +S D+ ++ Sbjct: 66 HSAFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQIV 125 Query: 152 SGDADGMIKIWQPNFSMVKEI-DAAHTESIRDMAFSSN--DSKFVTCSDDNILKIWNFSN 208 SG D +++W + + AHT+ + + FS + V+ DN++K+W+ ++ Sbjct: 126 SGGRDNALRVWNVKGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIAS 185 Query: 209 GKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTR 268 G+ L GH + S P+ L AS+ KD + +LWD G +S + + + Sbjct: 186 GRLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAA-GAPINQIC 244 Query: 269 FQPTKGNLLMAISKDKSCRVFDIRYSMKEL-------MCVRDETDYMTLEWHPINESMFT 321 F P + + A +K R+FD+ + + + M++ W +++ Sbjct: 245 FSPNRYWMCAA--TEKGIRIFDLENKDVIVELAPEAQQKSKKTPECMSIAWSADGNTLY- 301 Query: 322 LACYDGSLKHFDLL 335 D ++ + + Sbjct: 302 SGYTDNVIRVWSVS 315 Score = 81.3 bits (199), Expect = 9e-16, Method: Composition-based stats. Identities = 27/206 (13%), Positives = 72/206 (34%), Gaps = 16/206 (7%) Query: 10 QNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPN 69 N+ + + L+ + + + + + P ++ Sbjct: 120 DNRQIVSGGRDNALRVWNVKGECLHTLGRGA-----HTDWVSCVRFSPSLE--TPLIVSG 172 Query: 70 AYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFET 129 + +V ++ S + I ++ +P+G + G LW+ + + Sbjct: 173 GWDNLVKVWDIASGRLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALS 232 Query: 130 LMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMV-------KEIDAAHTESIRD 182 M A + + + +S + WM + G I+I+ V + + T Sbjct: 233 EMAAG-APINQICFSPNRYWMCAATEKG-IRIFDLENKDVIVELAPEAQQKSKKTPECMS 290 Query: 183 MAFSSNDSKFVTCSDDNILKIWNFSN 208 +A+S++ + + DN++++W+ S Sbjct: 291 IAWSADGNTLYSGYTDNVIRVWSVSE 316 Score = 48.6 bits (114), Expect = 6e-06, Method: Composition-based stats. Identities = 16/127 (12%), Positives = 38/127 (29%), Gaps = 13/127 (10%) Query: 300 CVRDETDYMTLEWHPINESMFTLA---CYDGSLKHF-DLLQNLNEPIL-----TIPYAHD 350 ++ ++T P + A D +L + + +E H Sbjct: 8 QLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHS 67 Query: 351 KCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPN----AYDDPTYNNKKINGWFFGIN 406 ++ ++ + G +A+ D ++R W + + D + Sbjct: 68 AFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQIVSG 127 Query: 407 NDINAVR 413 NA+R Sbjct: 128 GRDNALR 134 >6EMK-B nrPDB Length = 303 Score = 204 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 49/283 (17%), Positives = 110/283 (38%), Gaps = 11/283 (3%) Query: 107 RLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNF 166 LV A Y W A + +Q DS V ++ ++D + + ++++ Sbjct: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGH-QNVRLYDIRT 62 Query: 167 SMVKEI--DAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKS 224 + + H ++ ++F ++ VT S+D +K+W+ + R H+ V Sbjct: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNE 121 Query: 225 CDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDK 284 HP G + S +D +++WD C + T L++ + G++L A + Sbjct: 122 VVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKG 181 Query: 285 SCRVFDI-----RYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLN 339 +C V+++ +K + R + Y+T + D + + + + + Sbjct: 182 NCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFK 241 Query: 340 EPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARP 382 + T H + + +++ TA+ D +R W + Sbjct: 242 --LETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTR 282 Score = 204 bits (520), Expect = 5e-53, Method: Composition-based stats. Identities = 52/243 (21%), Positives = 95/243 (39%), Gaps = 25/243 (10%) Query: 1 MDGHNQN------QYQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLV 54 +GH N Q N+ + S+ +K + DV SP I Y + +V Sbjct: 71 FEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW-------DVRSPSIPRNYKHNAPVNEVV 123 Query: 55 VEPETSYTIDIMPPNAYRGRDRVINL-PSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATY 113 + P I G R+ +L ++ TH + + + ++ +G L A Sbjct: 124 IHPNQGELISCD----RDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANT 179 Query: 114 SGEFSLW------NASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFS 167 G +W +AS T +AH + +T + S D + + AD ++W + Sbjct: 180 KGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDD 239 Query: 168 -MVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCD 226 ++ H + D AFS++ + VT S D+ +++W+ S + R GHH Sbjct: 240 FKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVA 299 Query: 227 WHP 229 + Sbjct: 300 LND 302 Score = 132 bits (333), Expect = 2e-31, Method: Composition-based stats. Identities = 34/235 (14%), Positives = 85/235 (36%), Gaps = 10/235 (4%) Query: 87 LSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHD 146 S + + ++ + + R +V ++ G +W+ S + + H++ V + + Sbjct: 69 ASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPN 127 Query: 147 SDWMISGDADGMIKIWQP-NFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIW- 204 +IS D DG I+IW ++ S++ ++ +S+ S + +W Sbjct: 128 QGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWE 187 Query: 205 -----NFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCI-SSIL 258 + S+ K H + ++ +A+ S D+ ++W + +++ Sbjct: 188 MPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLD 247 Query: 259 KFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWH 313 + V F L+ S D R++D+ + + + Sbjct: 248 GHQRWVWDCAFSA-DSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 Score = 106 bits (264), Expect = 3e-23, Method: Composition-based stats. Identities = 45/200 (22%), Positives = 77/200 (38%), Gaps = 13/200 (6%) Query: 192 FVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSG 251 V+ D+ ++ W G R + V + + L+A+A N V+L+D R+ Sbjct: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQN-VRLYDIRTT 63 Query: 252 NC--ISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMT 309 N ++S + V FQ ++ S+D + +V+D+R + Sbjct: 64 NPNPVASFEGHRGNVTSVSFQQDNRW-MVTSSEDGTIKVWDVRSPSI-PRNYKHNAPVNE 121 Query: 310 LEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAA 369 + HP N+ DG+++ +DL +N LT D + SLS G + A A Sbjct: 122 VVIHP-NQGELISCDRDGNIRIWDLGENQCTHQLTPED--DTSLQSLSMASDGSMLAAAN 178 Query: 370 KDRTIRFWTRARPIDPNAYD 389 W PN D Sbjct: 179 TKGNCYVWEM-----PNHTD 193 Score = 68.6 bits (166), Expect = 6e-12, Method: Composition-based stats. Identities = 20/113 (17%), Positives = 47/113 (41%), Gaps = 3/113 (2%) Query: 276 LLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLL 335 +L++ D + R ++ + ++ LE ++ + A + +++ +D+ Sbjct: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEI-TNDKKLLATAGH-QNVRLYDIR 61 Query: 336 QNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAY 388 P+ + H +TS+S+ T+++D TI+ W P P Y Sbjct: 62 TTNPNPVAS-FEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY 113 >5FVM-C nrPDB Length = 303 Score = 204 bits (520), Expect = 5e-53, Method: Composition-based stats. Identities = 49/282 (17%), Positives = 111/282 (39%), Gaps = 11/282 (3%) Query: 107 RLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ--P 164 L A Y W A + +Q DS V ++ + D ++ + ++++ Sbjct: 4 ILASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGHLH-VRLYDIRS 62 Query: 165 NFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKS 224 N H ++ +AF + V+ S+D +K+W+ + +R H+ V Sbjct: 63 NNPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYK-HNAPVNE 121 Query: 225 CDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDK 284 HP G + S +D +++WD C + + +T L++ + G++L+A + Sbjct: 122 VAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNKG 181 Query: 285 SCRVFDI-----RYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLN 339 +C V+ + +++ + + T Y+T + D + + +++ N Sbjct: 182 NCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNIEDNY- 240 Query: 340 EPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRAR 381 + T H + + +++ TA D +R W + Sbjct: 241 -QLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLST 281 Score = 198 bits (502), Expect = 6e-51, Method: Composition-based stats. Identities = 47/243 (19%), Positives = 94/243 (38%), Gaps = 25/243 (10%) Query: 1 MDGHNQN------QYQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLV 54 +GH N Q +N+ + S+ +K + DV SP + Y + + Sbjct: 71 FEGHKGNVTSIAFQQENRWMVSSSEDGTIKVW-------DVRSPSVQRNYKHNAPVNEVA 123 Query: 55 VEPETSYTIDIMPPNAYRGRDRVINL-PSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATY 113 + P I G R+ +L ++ T+ + + + ++ +G LV Sbjct: 124 IHPNQGELISCDQ----DGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNN 179 Query: 114 SGEFSLW------NASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQP-NF 166 G +W +AS+ T ++H +T + S D + + AD ++W + Sbjct: 180 KGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNIEDN 239 Query: 167 SMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCD 226 ++ H + D AFS++ + VT D+ +++W+ S + R GHH Sbjct: 240 YQLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLSTSEIVRQYGGHHKGAVCVA 299 Query: 227 WHP 229 + Sbjct: 300 LND 302 Score = 151 bits (382), Expect = 5e-37, Method: Composition-based stats. Identities = 46/304 (15%), Positives = 111/304 (36%), Gaps = 15/304 (4%) Query: 65 IMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASS 124 I+ Y R + + + ++ T + + L A + L++ S Sbjct: 4 ILASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGHLH-VRLYDIRS 62 Query: 125 FTF--ETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRD 182 + + H VT++ + ++ WM+S DG IK+W V+ H + + Sbjct: 63 NNPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYK-HNAPVNE 121 Query: 183 MAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLS-GHHWDVKSCDWHPEMGLIASASKDN 241 +A N + ++C D ++IW+ + L+ + ++S + ++ + + Sbjct: 122 VAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNKG 181 Query: 242 LVKLW------DPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSM 295 +W D + ++ + + N L S D + RV++I + Sbjct: 182 NCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKN-LATCSADHTARVWNIEDNY 240 Query: 296 KELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITS 355 + + ++ + + AC D ++ +DL + +E + H + Sbjct: 241 QLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDL--STSEIVRQYGGHHKGAV-C 297 Query: 356 LSYN 359 ++ N Sbjct: 298 VALN 301 Score = 141 bits (354), Expect = 8e-34, Method: Composition-based stats. Identities = 41/238 (17%), Positives = 87/238 (36%), Gaps = 8/238 (3%) Query: 150 MISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNG 209 + S D I+ W+ + + + +S+ +++++ + Sbjct: 5 LASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGH-LHVRLYDIRSN 63 Query: 210 KQ--ERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKT 267 GH +V S + E + S+S+D +K+WD RS + + K V + Sbjct: 64 NPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPS-VQRNYKHNAPVNEV 122 Query: 268 RFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDG 327 P +G L+ + +D + R++D+ + ++ + + SM G Sbjct: 123 AIHPNQGELI-SCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNKG 181 Query: 328 SLKHFDLLQNLNEPIL---TIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARP 382 + + + + + L T +H K IT + + AT + D T R W Sbjct: 182 NCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNIEDN 239 Score = 90.2 bits (222), Expect = 2e-18, Method: Composition-based stats. Identities = 32/186 (17%), Positives = 63/186 (33%), Gaps = 12/186 (6%) Query: 233 LIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIR 292 ++ASA D+ ++ W+ +G C +I V + K L A R++DIR Sbjct: 4 ILASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGHL--HVRLYDIR 61 Query: 293 YSMK-ELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDK 351 + + +T + DG++K +D+ P + Y H+ Sbjct: 62 SNNPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVR----SPSVQRNYKHNA 117 Query: 352 CITSLSYNPVGHIFATAAKDRTIRFWTRARP-----IDPNAYDDPTYNNKKINGWFFGIN 406 + ++ +P + +D IR W + P + +G Sbjct: 118 PVNEVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAG 177 Query: 407 NDINAV 412 N+ Sbjct: 178 NNKGNC 183 >4V8M-A7 nrPDB Length = 318 Score = 204 bits (519), Expect = 7e-53, Method: Composition-based stats. Identities = 56/293 (19%), Positives = 114/293 (38%), Gaps = 24/293 (8%) Query: 108 LVVATYSGEFSLW---------NASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGM 158 +V + W S + ++ H + V+ + S++ ++ +S D Sbjct: 31 VVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSAFVSDVALSNNGNFAVSASWDHS 90 Query: 159 IKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSG- 217 +++W + HT+ + +AFS ++ + V+ DN L++WN + G Sbjct: 91 LRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQIVSGGRDNALRVWNVKGECMHTLSRGA 150 Query: 218 HHWDVKSCDWHP--EMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGN 275 H V + P + +I S DNLVK+WD +G ++ + + V P G+ Sbjct: 151 HTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGRLVTDLKGHTNYVTSVTVSP-DGS 209 Query: 276 LLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLL 335 L + KD R++D+ + L + + + P + A + ++ FDL Sbjct: 210 LCASSDKDGVARLWDL-TKGEALSEMAAGAPINQICFSP--NRYWMCAATEKGIRIFDLE 266 Query: 336 QNLNEPILTIPYAHDKC------ITSLSYNPVGHIFATAAKDRTIRFWTRARP 382 + I+ + H S++++ G + D IR W + Sbjct: 267 N--KDIIVELAPEHQGSKKIVPECVSIAWSADGSTLYSGYTDNVIRVWGVSEN 317 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 59/295 (20%), Positives = 117/295 (39%), Gaps = 19/295 (6%) Query: 54 VVEPETSYTIDIMPPNAYRGRDRV-INLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVAT 112 VV T+ PN R LP + + + + G V A+ Sbjct: 31 VVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRL----EGHSAFVSDVALSNNGNFAVSAS 86 Query: 113 YSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEI 172 + LWN + + H V ++ +S D+ ++SG D +++W + + Sbjct: 87 WDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQIVSGGRDNALRVWNVKGECMHTL 146 Query: 173 -DAAHTESIRDMAFSS--NDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHP 229 AHT+ + + FS + V+ DN++K+W+ + G+ L GH V S P Sbjct: 147 SRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGRLVTDLKGHTNYVTSVTVSP 206 Query: 230 EMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVF 289 + L AS+ KD + +LWD G +S + + + F P + + A +K R+F Sbjct: 207 DGSLCASSDKDGVARLWDLTKGEALSEMAA-GAPINQICFSPNRYWMCAA--TEKGIRIF 263 Query: 290 DIRYSMKELMCVRDE-------TDYMTLEWHPINESMFTLACYDGSLKHFDLLQN 337 D+ + + + +++ W +++ D ++ + + +N Sbjct: 264 DLENKDIIVELAPEHQGSKKIVPECVSIAWSADGSTLY-SGYTDNVIRVWGVSEN 317 Score = 84.0 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 30/208 (14%), Positives = 75/208 (36%), Gaps = 16/208 (7%) Query: 10 QNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPN 69 N+ + + L+ + + + S + + P ++ Sbjct: 120 DNRQIVSGGRDNALRVWNVKGECMHTLSRGA-----HTDWVSCVRFSPSLD--APVIVSG 172 Query: 70 AYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFET 129 + +V +L + + + ++ +P+G + G LW+ + + Sbjct: 173 GWDNLVKVWDLATGRLVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALS 232 Query: 130 LMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQP-NFSMVKEIDAAHTES------IRD 182 M A + + + +S + WM + G I+I+ N ++ E+ H S Sbjct: 233 EMAAG-APINQICFSPNRYWMCAATEKG-IRIFDLENKDIIVELAPEHQGSKKIVPECVS 290 Query: 183 MAFSSNDSKFVTCSDDNILKIWNFSNGK 210 +A+S++ S + DN++++W S Sbjct: 291 IAWSADGSTLYSGYTDNVIRVWGVSENA 318 >6G51-g nrPDB Length = 317 Score = 204 bits (518), Expect = 8e-53, Method: Composition-based stats. Identities = 58/295 (19%), Positives = 117/295 (39%), Gaps = 25/295 (8%) Query: 51 PNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVV 110 P++++ TI + +P + + H + + + +G+ + Sbjct: 28 PDMILSASRDKTI---IMWKLTRDETNYGIPQR----ALRGHSHFVSDVVISSDGQFALS 80 Query: 111 ATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVK 170 ++ G LW+ ++ T H V ++ +S D+ ++SG D IK+W + K Sbjct: 81 GSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN-TLGVCK 139 Query: 171 EI--DAAHTESIRDMAFSSNDS--KFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCD 226 D +H+E + + FS N S V+C D ++K+WN +N K + GH + + Sbjct: 140 YTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVT 199 Query: 227 WHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSC 286 P+ L AS KD LWD G + ++ + F P + L A S Sbjct: 200 VSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPNRYWLCAATGP--SI 256 Query: 287 RVFD---------IRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHF 332 +++D ++ + + +L W +++F D ++ + Sbjct: 257 KIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA-GYTDNLVRVW 310 Score = 197 bits (500), Expect = 9e-51, Method: Composition-based stats. Identities = 59/289 (20%), Positives = 107/289 (37%), Gaps = 18/289 (6%) Query: 106 RRLVVATYSGEFSLWNAS-----SFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIK 160 ++ A+ +W + + ++ H V+ + S D + +SG DG ++ Sbjct: 29 DMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLR 88 Query: 161 IWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLS-GHH 219 +W HT+ + +AFSS++ + V+ S D +K+WN + V H Sbjct: 89 LWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHS 148 Query: 220 WDVKSCDWHPEMG--LIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLL 277 V + P +I S D LVK+W+ + ++ + + P G+L Sbjct: 149 EWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSP-DGSLC 207 Query: 278 MAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQN 337 + KD ++D+ L + L + P + A S+K +DL Sbjct: 208 ASGGKDGQAMLWDLNEGKH-LYTLDGGDIINALCFSP--NRYWLCAATGPSIKIWDLEGK 264 Query: 338 ------LNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRA 380 E I T A TSL+++ G D +R W Sbjct: 265 IIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVT 313 Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 59/267 (22%), Positives = 111/267 (41%), Gaps = 16/267 (5%) Query: 126 TFETLMQAHDSAVTTMKYSHDS-DWMISGDADGMIKIWQP-----NFSMVKEIDAAHTES 179 T ++ H+ VT + + D ++S D I +W+ N+ + + H+ Sbjct: 6 TLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHF 65 Query: 180 IRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASK 239 + D+ SS+ ++ S D L++W+ + G R GH DV S + + I S S+ Sbjct: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125 Query: 240 DNLVKLWDPRSGNCISSI--LKFKHTVLKTRFQPTKGN-LLMAISKDKSCRVFDIRYSMK 296 D +KLW+ G C ++ V RF P N ++++ DK +V+++ Sbjct: 126 DKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKL 184 Query: 297 ELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSL 356 + + T+ P + S+ DG +DL N + + T+ I +L Sbjct: 185 KTNHIGHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDL--NEGKHLYTLDGG--DIINAL 239 Query: 357 SYNPVGHIFATAAKDRTIRFWTRARPI 383 ++P + AA +I+ W I Sbjct: 240 CFSPN-RYWLCAATGPSIKIWDLEGKI 265 Score = 144 bits (362), Expect = 1e-34, Method: Composition-based stats. Identities = 39/236 (16%), Positives = 86/236 (36%), Gaps = 12/236 (5%) Query: 168 MVKEIDAAHTESIRDMAFSSN-DSKFVTCSDDNILKIWNFSNGK-----QERVLSGHHWD 221 ++ H + +A + ++ S D + +W + + +R L GH Sbjct: 6 TLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHF 65 Query: 222 VKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAIS 281 V + S S D ++LWD +G + VL F + ++ S Sbjct: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI-VSGS 124 Query: 282 KDKSCRVFDIRYSMKELMCVRDETDYM-TLEWHP-INESMFTLACYDGSLKHFDLLQNLN 339 +DK+ ++++ K + ++++ + + P + + +D +K ++L N Sbjct: 125 RDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA---N 181 Query: 340 EPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNN 395 + T H + +++ +P G + A+ KD W D N Sbjct: 182 CKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIIN 237 Score = 124 bits (310), Expect = 1e-28, Method: Composition-based stats. Identities = 44/292 (15%), Positives = 97/292 (33%), Gaps = 59/292 (20%) Query: 14 QIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRG 73 + S+ + + R + P L H + ++V+ + + + ++ G Sbjct: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALR-GHSHFVSDVVISSDGQFALS----GSWDG 85 Query: 74 RDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQ- 132 R+ +L + T + ++ ++ + R++V + LWN + +Q Sbjct: 86 TLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL-GVCKYTVQD 144 Query: 133 -AHDSAVTTMKYSHDSD--WMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSND 189 +H V+ +++S +S ++S D ++K+W +K HT + + S + Sbjct: 145 ESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDG 204 Query: 190 SKFVTCSDDNILKIWNFSNGKQERVLSG-------------------------------- 217 S + D +W+ + GK L G Sbjct: 205 SLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGK 264 Query: 218 -----HHWDV------------KSCDWHPEMGLIASASKDNLVKLWDPRSGN 252 +V S W + + + DNLV++W G Sbjct: 265 IIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 Score = 86.7 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 30/211 (14%), Positives = 70/211 (33%), Gaps = 18/211 (8%) Query: 10 QNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPN 69 N+ + S+ +K + T Y + + + P +S I+ Sbjct: 116 DNRQIVSGSRDKTIKLWNTLGVCK-----YTVQDESHSEWVSCVRFSPNSSN--PIIVSC 168 Query: 70 AYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFET 129 + +V NL + + + + +P+G G+ LW+ + Sbjct: 169 GWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLY 228 Query: 130 LMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMV---------KEIDAAHTESI 180 + D + + +S + W+ + IKIW ++ A Sbjct: 229 TLDGGD-IINALCFSPNRYWLCAATG-PSIKIWDLEGKIIVDELKQEVISTSSKAEPPQC 286 Query: 181 RDMAFSSNDSKFVTCSDDNILKIWNFSNGKQ 211 +A+S++ DN++++W + G + Sbjct: 287 TSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317 >5WLC-LO nrPDB Length = 923 Score = 198 bits (502), Expect = 6e-51, Method: Composition-based stats. Identities = 69/442 (15%), Positives = 142/442 (32%), Gaps = 50/442 (11%) Query: 9 YQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPP 68 ++ + S+ K + ++++ N R + + + Sbjct: 156 QDSRFILTTSKDLSAKIWSVDSEEKNLAATTFN---GHRDYVMGAFFSHDQEKIYTV--- 209 Query: 69 NAYRGRDRVINL-------------------PSKFTHLSS-NKVKHV-------IPAIQW 101 + G V + S KH + + + Sbjct: 210 -SKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTF 268 Query: 102 TPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDAD-GMIK 160 P R L V SGEF L++ FT + + V T+ + +W+ G + G + Sbjct: 269 HPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLL 328 Query: 161 I--WQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGH 218 + WQ ++K+ H +S +A+S + S+ VT S+D +K+W+ ++G H Sbjct: 329 VYEWQSESYILKQ--QGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEH 386 Query: 219 HWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILK-FKHTVLKTRFQPTKGNLL 277 V + + ++ S+S D V+ WD + + P+ + Sbjct: 387 TSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVC 446 Query: 278 MAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQN 337 + V+ ++ E L + S+ A +D +++ + + Sbjct: 447 AGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFS-QENSVLASASWDKTIRIWSIFGR 505 Query: 338 LNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYD-DPTYNNK 396 + Y + +LS P G A + I + D + Sbjct: 506 SQQVEPIEVY---SDVLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISG 562 Query: 397 KINGWFFGINNDINAVREKSEF 418 + N F N E+S+F Sbjct: 563 RFNQDRFTAKNS-----ERSKF 579 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 60/430 (13%), Positives = 141/430 (32%), Gaps = 53/430 (12%) Query: 1 MDGHNQN------QYQNQNQIQQSQQPPLKKYVTQRR----------------SVDVSSP 38 +GH + + S+ + + +R VD+S Sbjct: 187 FNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKY 246 Query: 39 YINLYYNR-----RHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVK 93 + + + + P T ++ G R+ +LP + + Sbjct: 247 SWRITKKHFFYANQAKVKCVTFHPATR----LLAVGFTSGEFRLYDLPDFTLIQQLSMGQ 302 Query: 94 HVIPAIQWTPEGRRLVVATYS-GEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMIS 152 + + + G L + G+ ++ S ++ Q H + ++ YS D +++ Sbjct: 303 NPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVT 362 Query: 153 GDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQE 212 DG IK+W HT S+ + F+ + S D ++ W+ + Sbjct: 363 ASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNF 422 Query: 213 RVLSGHHW-DVKSCDWHPEMGLIASASKDNL-VKLWDPRSGNCISSILKFKHTVLKTRFQ 270 R +G P ++ + S DN + +W ++G + ++ + V F Sbjct: 423 RTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFS 482 Query: 271 PTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLK 330 + ++L + S DK+ R++ I +++ + +D + L P + ++ G + Sbjct: 483 -QENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRP-DGKEVAVSTLKGQIS 540 Query: 331 HFDLLQNL-----------------NEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRT 373 F++ + K T++ Y+ G + + Sbjct: 541 IFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNS 600 Query: 374 IRFWTRARPI 383 I + + Sbjct: 601 ICLYDVPNEV 610 Score = 164 bits (416), Expect = 5e-41, Method: Composition-based stats. Identities = 65/388 (16%), Positives = 132/388 (34%), Gaps = 53/388 (13%) Query: 35 VSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSK--FTHLSSNKV 92 +++ Y R + + + + + I I GR ++N ++ H + + Sbjct: 43 INNKSFTFEYEHRKNIAAIDLNKQGTLLISIDE----DGRAILVNFKARNVLHHFNFKEK 98 Query: 93 KHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQ---------AHDSAVTTMKY 143 A++++P+GR +A+ +W + H +T++ + Sbjct: 99 C---SAVKFSPDGRLFALAS-GRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTW 154 Query: 144 SHDSDWMISGDADGMIKIWQPNF---SMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNI 200 S DS ++++ D KIW + ++ H + + FS + K T S D Sbjct: 155 SQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGA 214 Query: 201 LKIWNFSNGKQERV---------------------------LSGHHWDVKSCDWHPEMGL 233 + +W F+ + + VK +HP L Sbjct: 215 VFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRL 274 Query: 234 IASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRY 293 +A +L+D I + ++ V T L SK V++ + Sbjct: 275 LAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQS 334 Query: 294 SMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCI 353 L +L + P + S A DG +K +D+ L H + Sbjct: 335 ESYILKQQGHFDSTNSLAYSP-DGSRVVTASEDGKIKVWDITSGF---CLATFEEHTSSV 390 Query: 354 TSLSYNPVGHIFATAAKDRTIRFWTRAR 381 T++ + G + +++ D T+R W R Sbjct: 391 TAVQFAKRGQVMFSSSLDGTVRAWDLIR 418 Score = 140 bits (353), Expect = 1e-33, Method: Composition-based stats. Identities = 79/490 (16%), Positives = 164/490 (33%), Gaps = 62/490 (12%) Query: 9 YQNQNQ-IQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMP 67 + S+ L Y Q S YI +L P+ S + Sbjct: 312 QTGEWLAFGSSKLGQLLVYEWQSES------YILKQQGHFDSTNSLAYSPDGSRVVT--- 362 Query: 68 PNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTF 127 + G+ +V ++ S F + + + A+Q+ G+ + ++ G W+ + Sbjct: 363 -ASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRN 421 Query: 128 ETLMQAHDSA-VTTMKYSHDSDWMISGDADG-MIKIWQPNFSMVKEIDAAHTESIRDMAF 185 + + + + +G D I +W + + + H + ++F Sbjct: 422 FRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSF 481 Query: 186 SSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKL 245 S +S + S D ++IW+ Q+ + DV + P+ +A ++ + + Sbjct: 482 SQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQISI 541 Query: 246 ---------------WDPRSGNCISSILKFKHTVLKTRFQ----PTKGNLLMAISKDKSC 286 D SG K++ F G ++A + S Sbjct: 542 FNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSI 601 Query: 287 RVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACY----DGSLKHFDLLQNLNEPI 342 ++D+ + + + +N T A D + ++ DL ++ + Sbjct: 602 CLYDVPNEVLLKRFIVSRNMALNGTLEFLNSKKMTEAGSLDLIDDAGENSDLEDRIDNSL 661 Query: 343 LTIPYA---------HDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPI--DPNAYDDP 391 + +TS+ ++P + FA A+ + + ++ I DP D Sbjct: 662 PGSQRGGDLSTRKMRPEVRVTSVQFSPTANAFAAASTEGLL-IYSTNDTILFDPFDLDVD 720 Query: 392 TYNNKKINGWFFGINNDINAVREKSEFGAAPPPPATLEPHALPNMNGFINKKPRQEIPGI 451 ++ + A+REK +F A L L +N P +EIP + Sbjct: 721 VTP-----------HSTVEALREK-QFLNALVMAFRLNEEYL--INKVYEAIPIKEIPLV 766 Query: 452 DSNIKSSTLP 461 SNI + LP Sbjct: 767 ASNIPAIYLP 776 Score = 126 bits (317), Expect = 1e-29, Method: Composition-based stats. Identities = 62/401 (15%), Positives = 119/401 (29%), Gaps = 94/401 (23%) Query: 99 IQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGM 158 I ++ +G++L+ S+++ + T H + + + +IS D DG Sbjct: 20 ITFSDDGKQLLS-PVGNRVSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDGR 78 Query: 159 IKIWQPNFSMVKEIDAAH---TESIRDMAFSSNDSKFVTCSDDNILKIW---NFSNGKQ- 211 + + H E + FS + F S L+IW + + +Q Sbjct: 79 AIL----VNFKARNVLHHFNFKEKCSAVKFSPDGRLFALAS-GRFLQIWKTPDVNKDRQF 133 Query: 212 -----ERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNC---ISSILKFKHT 263 RV +GH D+ S W + I + SKD K+W S ++ + Sbjct: 134 APFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDY 193 Query: 264 VLKTRFQPTKGNLLMAISKDKSCRVFDIRYS---------------------------MK 296 V+ F + +SKD + V++ K Sbjct: 194 VMG-AFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITK 252 Query: 297 ELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTI----------- 345 + ++ + +HP + + G + +DL L++ Sbjct: 253 KHFFYANQAKVKCVTFHPA-TRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVN 311 Query: 346 -----------------------------PYAHDKCITSLSYNPVGHIFATAAKDRTIRF 376 H SL+Y+P G TA++D I+ Sbjct: 312 QTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKV 371 Query: 377 WTR--ARPIDPNAYDDPTYNNKKI--NGWFFGINNDINAVR 413 W + + + G ++ VR Sbjct: 372 WDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVR 412 >3MKQ-A nrPDB Length = 814 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 58/308 (18%), Positives = 112/308 (36%), Gaps = 18/308 (5%) Query: 93 KHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMIS 152 + I + P ++ YSG +WN + +Q ++ V K+ +W+I Sbjct: 13 SDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKFIARKNWIIV 72 Query: 153 GDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNG-KQ 211 G D I+++ N AH + IR +A ++ SDD +K+WN+ N Sbjct: 73 GSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWAL 132 Query: 212 ERVLSGHHWDVKSCDWHP-EMGLIASASKDNLVKLWDPRSGNCISSI-LKFKHTVLKTRF 269 E+ GH V ++P + AS D VK+W ++ + V + Sbjct: 133 EQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDY 192 Query: 270 QP-TKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGS 328 P ++ S D + +++D + ++ +HP + DG+ Sbjct: 193 YPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPT-LPIIISGSEDGT 251 Query: 329 LKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGH--IFATAAKDRTIRFWTRARPIDPN 386 LK ++ E L + ++ +P G A+ + + Sbjct: 252 LKIWNSSTYKVEKTLNVGLERS---WCIATHPTGRKNYIASG--------FDNGFTVLSL 300 Query: 387 AYDDPTYN 394 D+PT + Sbjct: 301 GNDEPTLS 308 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 42/258 (16%), Positives = 101/258 (39%), Gaps = 6/258 (2%) Query: 127 FETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFS 186 + V + + W+++ G ++IW + +R F Sbjct: 5 IKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKFI 64 Query: 187 SNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW 246 + + + SDD ++++N++ G++ H ++S HP + S S D VKLW Sbjct: 65 ARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLW 124 Query: 247 DPRSGNCI-SSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELM-CVRDE 304 + + + + +H V+ F P + + D++ +V+ + S E Sbjct: 125 NWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQE 184 Query: 305 TDYMTLEWHPINESMF-TLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGH 363 ++++P+ + + A D ++K +D + + H ++ ++P Sbjct: 185 RGVNYVDYYPLPDKPYMITASDDLTIKIWDY---QTKSCVATLEGHMSNVSFAVFHPTLP 241 Query: 364 IFATAAKDRTIRFWTRAR 381 I + ++D T++ W + Sbjct: 242 IIISGSEDGTLKIWNSST 259 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 56/332 (16%), Positives = 129/332 (38%), Gaps = 25/332 (7%) Query: 45 NRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPE 104 NR + + P + + + Y GR + N ++ S + + A ++ Sbjct: 11 NRSDRVKGIDFHPTEPWVLTTL----YSGRVEIWNYETQVEVRSIQVTETPVRAGKFIAR 66 Query: 105 GRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQP 164 ++V + ++N ++ +AH + ++ +++SG D +K+W Sbjct: 67 KNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNW 126 Query: 165 NFS-MVKEIDAAHTESIRDMAFSSND-SKFVTCSDDNILKIWNFSNGKQERVL-SGHHWD 221 + +++ H + +AF+ D S F + D +K+W+ L +G Sbjct: 127 ENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERG 186 Query: 222 VKSCDW--HPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMA 279 V D+ P+ + +AS D +K+WD ++ +C++++ V F PT ++++ Sbjct: 187 VNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLP-IIIS 245 Query: 280 ISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLN 339 S+D + ++++ E + HP + + +D L + Sbjct: 246 GSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEP 305 Query: 340 EPILTIPYAHDKCITSLSYNPVGHIFATAAKD 371 +LS +PVG + + K+ Sbjct: 306 ---------------TLSLDPVGKLVWSGGKN 322 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 33/173 (19%), Positives = 68/173 (39%), Gaps = 5/173 (2%) Query: 210 KQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRF 269 ++ S VK D+HP + + V++W+ + + SI + V +F Sbjct: 4 DIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKF 63 Query: 270 QPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSL 329 K +++ S D RVF+ K + ++ HP + D ++ Sbjct: 64 IARKNWIIV-GSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVL-SGSDDLTV 121 Query: 330 KHFDLLQNLNEPILTIPYAHDKCITSLSYNP-VGHIFATAAKDRTIRFWTRAR 381 K ++ N + H+ + +++NP FA+ DRT++ W+ + Sbjct: 122 KLWNWENNWA--LEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQ 172 Score = 44.7 bits (104), Expect = 8e-05, Method: Composition-based stats. Identities = 25/201 (12%), Positives = 54/201 (26%), Gaps = 26/201 (12%) Query: 10 QNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPN 69 I S +K + Q +S + + V P T+ I+ Sbjct: 197 DKPYMITASDDLTIKIWDYQTKSC------VATLEGHMSNVSFAVFHP----TLPIIISG 246 Query: 70 AYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEG--RRLVVATYSGEFSLWNASSFTF 127 + G ++ N + + N I P G + +G F++ + + Sbjct: 247 SEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNG-FTVLSLGNDEP 305 Query: 128 ETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIW---QPNFSMVKEIDAAHTESI---- 180 + V + +S + + I + + S+ Sbjct: 306 TLSL----DPVGKLVWSGGKN--AAASDIFTAVIRGNEEVEQDEPLSLQTKELGSVDVFP 359 Query: 181 RDMAFSSNDSKFVTCSDDNIL 201 + +A S N D + Sbjct: 360 QSLAHSPNGRFVTVVGDGEYV 380 Score = 30.1 bits (66), Expect = 2.0, Method: Composition-based stats. Identities = 8/77 (10%), Positives = 19/77 (24%), Gaps = 6/77 (7%) Query: 342 ILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPID--PNAYDDPTYNNKKI- 398 I + + ++P T + W ++ + K Sbjct: 5 IKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKFI 64 Query: 399 --NGWFFGINNDINAVR 413 W + +D +R Sbjct: 65 ARKNWII-VGSDDFRIR 80 >5I2T-A nrPDB Length = 742 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 69/442 (15%), Positives = 142/442 (32%), Gaps = 50/442 (11%) Query: 9 YQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPP 68 ++ + S+ K + ++++ N R + + + Sbjct: 181 QDSRFILTTSKDLSAKIWSVDSEEKNLAATTFN---GHRDYVMGAFFSHDQEKIYTV--- 234 Query: 69 NAYRGRDRVINL-------------------PSKFTHLSS-NKVKHV-------IPAIQW 101 + G V + S KH + + + Sbjct: 235 -SKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTF 293 Query: 102 TPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDAD-GMIK 160 P R L V SGEF L++ FT + + V T+ + +W+ G + G + Sbjct: 294 HPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLL 353 Query: 161 I--WQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGH 218 + WQ ++K+ H +S +A+S + S+ VT S+D +K+W+ ++G H Sbjct: 354 VYEWQSESYILKQ--QGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEH 411 Query: 219 HWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILK-FKHTVLKTRFQPTKGNLL 277 V + + ++ S+S D V+ WD + + P+ + Sbjct: 412 TSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVC 471 Query: 278 MAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQN 337 + V+ ++ E L + S+ A +D +++ + + Sbjct: 472 AGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFS-QENSVLASASWDKTIRIWSIFGR 530 Query: 338 LNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYD-DPTYNNK 396 + Y + +LS P G A + I + D + Sbjct: 531 SQQVEPIEVY---SDVLALSMRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISG 587 Query: 397 KINGWFFGINNDINAVREKSEF 418 + N F N E+S+F Sbjct: 588 RFNQDRFTAKNS-----ERSKF 604 Score = 178 bits (451), Expect = 5e-45, Method: Composition-based stats. Identities = 60/430 (13%), Positives = 141/430 (32%), Gaps = 53/430 (12%) Query: 1 MDGHNQN------QYQNQNQIQQSQQPPLKKYVTQRR----------------SVDVSSP 38 +GH + + S+ + + +R VD+S Sbjct: 212 FNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKY 271 Query: 39 YINLYYNR-----RHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVK 93 + + + + P T ++ G R+ +LP + + Sbjct: 272 SWRITKKHFFYANQAKVKCVTFHPATR----LLAVGFTSGEFRLYDLPDFTLIQQLSMGQ 327 Query: 94 HVIPAIQWTPEGRRLVVATYS-GEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMIS 152 + + + G L + G+ ++ S ++ Q H + ++ YS D +++ Sbjct: 328 NPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVT 387 Query: 153 GDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQE 212 DG IK+W HT S+ + F+ + S D ++ W+ + Sbjct: 388 ASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNF 447 Query: 213 RVLSGHHW-DVKSCDWHPEMGLIASASKDNL-VKLWDPRSGNCISSILKFKHTVLKTRFQ 270 R +G P ++ + S DN + +W ++G + ++ + V F Sbjct: 448 RTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFS 507 Query: 271 PTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLK 330 + ++L + S DK+ R++ I +++ + +D + L P + ++ G + Sbjct: 508 -QENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRP-DGKEVAVSTLKGQIS 565 Query: 331 HFDLLQNL-----------------NEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRT 373 F++ + K T++ Y+ G + + Sbjct: 566 IFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNS 625 Query: 374 IRFWTRARPI 383 I + + Sbjct: 626 ICLYDVPNEV 635 Score = 162 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 65/388 (16%), Positives = 132/388 (34%), Gaps = 53/388 (13%) Query: 35 VSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSK--FTHLSSNKV 92 +++ Y R + + + + + I I GR ++N ++ H + + Sbjct: 68 INNKSFTFEYEHRKNIAAIDLNKQGTLLISIDE----DGRAILVNFKARNVLHHFNFKEK 123 Query: 93 KHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQ---------AHDSAVTTMKY 143 A++++P+GR +A+ +W + H +T++ + Sbjct: 124 C---SAVKFSPDGRLFALAS-GRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTW 179 Query: 144 SHDSDWMISGDADGMIKIWQPNF---SMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNI 200 S DS ++++ D KIW + ++ H + + FS + K T S D Sbjct: 180 SQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGA 239 Query: 201 LKIWNFSNGKQERV---------------------------LSGHHWDVKSCDWHPEMGL 233 + +W F+ + + VK +HP L Sbjct: 240 VFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRL 299 Query: 234 IASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRY 293 +A +L+D I + ++ V T L SK V++ + Sbjct: 300 LAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQS 359 Query: 294 SMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCI 353 L +L + P + S A DG +K +D+ L H + Sbjct: 360 ESYILKQQGHFDSTNSLAYSP-DGSRVVTASEDGKIKVWDITSGF---CLATFEEHTSSV 415 Query: 354 TSLSYNPVGHIFATAAKDRTIRFWTRAR 381 T++ + G + +++ D T+R W R Sbjct: 416 TAVQFAKRGQVMFSSSLDGTVRAWDLIR 443 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 57/401 (14%), Positives = 131/401 (32%), Gaps = 45/401 (11%) Query: 9 YQNQNQ-IQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMP 67 + S+ L Y Q S YI +L P+ S + Sbjct: 337 QTGEWLAFGSSKLGQLLVYEWQSES------YILKQQGHFDSTNSLAYSPDGSRVVT--- 387 Query: 68 PNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTF 127 + G+ +V ++ S F + + + A+Q+ G+ + ++ G W+ + Sbjct: 388 -ASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRN 446 Query: 128 ETLMQAHDSA-VTTMKYSHDSDWMISGDADG-MIKIWQPNFSMVKEIDAAHTESIRDMAF 185 + + + + +G D I +W + + + H + ++F Sbjct: 447 FRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSF 506 Query: 186 SSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKL 245 S +S + S D ++IW+ Q+ + DV + P+ +A ++ + + Sbjct: 507 SQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQISI 566 Query: 246 ---------------WDPRSGNCISSILKFKHTVLKTRFQ----PTKGNLLMAISKDKSC 286 D SG K++ F G ++A + S Sbjct: 567 FNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSI 626 Query: 287 RVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACY----DGSLKHFDLLQNLNEPI 342 ++D+ + + + +N T A D + ++ DL ++ + Sbjct: 627 CLYDVPNEVLLKRFIVSRNMALNGTLEFLNSKKMTEAGSLDLIDDAGENSDLEDRIDNSL 686 Query: 343 LTIPYA---------HDKCITSLSYNPVGHIFATAAKDRTI 374 + +TS+ ++P + FA A+ + + Sbjct: 687 PGSQRGGDLSTRKMRPEVRVTSVQFSPTANAFAAASTEGLL 727 Score = 125 bits (313), Expect = 5e-29, Method: Composition-based stats. Identities = 62/401 (15%), Positives = 119/401 (29%), Gaps = 94/401 (23%) Query: 99 IQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGM 158 I ++ +G++L+ S+++ + T H + + + +IS D DG Sbjct: 45 ITFSDDGKQLLS-PVGNRVSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDGR 103 Query: 159 IKIWQPNFSMVKEIDAAH---TESIRDMAFSSNDSKFVTCSDDNILKIW---NFSNGKQ- 211 + + H E + FS + F S L+IW + + +Q Sbjct: 104 AIL----VNFKARNVLHHFNFKEKCSAVKFSPDGRLFALAS-GRFLQIWKTPDVNKDRQF 158 Query: 212 -----ERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNC---ISSILKFKHT 263 RV +GH D+ S W + I + SKD K+W S ++ + Sbjct: 159 APFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDY 218 Query: 264 VLKTRFQPTKGNLLMAISKDKSCRVFDIRYS---------------------------MK 296 V+ F + +SKD + V++ K Sbjct: 219 VMG-AFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITK 277 Query: 297 ELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTI----------- 345 + ++ + +HP + + G + +DL L++ Sbjct: 278 KHFFYANQAKVKCVTFHPA-TRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVN 336 Query: 346 -----------------------------PYAHDKCITSLSYNPVGHIFATAAKDRTIRF 376 H SL+Y+P G TA++D I+ Sbjct: 337 QTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKV 396 Query: 377 WTR--ARPIDPNAYDDPTYNNKKI--NGWFFGINNDINAVR 413 W + + + G ++ VR Sbjct: 397 WDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVR 437 >5Y88-O nrPDB Length = 451 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 63/416 (15%), Positives = 137/416 (32%), Gaps = 18/416 (4%) Query: 1 MDGHNQ--NQYQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLP-----NL 53 M+G +Y + S KK Q D S + + H N Sbjct: 41 MEGQKSLLMRYDTYRKESSSFSGEGKKVTLQHVPTDFSEASQAVISKKDHDTHASAFVNK 100 Query: 54 VVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTP-EGRRLVVAT 112 + +PE + + + + + P K + + + + + P + + + Sbjct: 101 IFQPEVAEELIVNRYEKLLSQRPEWHAPWKLSRVING-HLGWVRCVAIDPVDNEWFITGS 159 Query: 113 YSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEI 172 +W+ ++ +T + H V + S ++ S D +K W + + Sbjct: 160 NDTTMKVWDLATGKLKTTLAGHVMTVRDVAVSDRHPYLFSVSEDKTVKCWDLEKNQIIRD 219 Query: 173 DAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMG 232 H +R ++ T D+++K+W+ L GH + P Sbjct: 220 YYGHLSGVRTVSIHPTLDLIATAGRDSVIKLWDMRTRIPVITLVGHKGPINQVQCTPVDP 279 Query: 233 LIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIR 292 + S+S D V+LWD +G + + K +V T P + ++ A + D R + + Sbjct: 280 QVVSSSTDATVRLWDVVAGKTMKVLTHHKRSVRATALHPKEFSVASACTDD--IRSWGLA 337 Query: 293 YSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPY----- 347 ++T + ++ +F +G L +D L Sbjct: 338 EGSLLTNFESEKTGIINTLSINQDDVLFA-GGDNGVLSFYDYKSGHKYQSLATREMVGSL 396 Query: 348 AHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFF 403 ++ + +++ G T D++I+ W + N ++ F Sbjct: 397 EGERSVLCSTFDKTGLRLITGEADKSIKIWK-QDETATKESEPGLAWNPNLSAKRF 451 >2YNP-A nrPDB Length = 604 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 59/308 (19%), Positives = 112/308 (36%), Gaps = 18/308 (5%) Query: 93 KHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMIS 152 + I + P ++ YSG LWN + +Q ++ V K+ +W+I Sbjct: 13 SDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIARKNWIIV 72 Query: 153 GDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNG-KQ 211 G D I+++ N AH + IR +A ++ SDD +K+WN+ N Sbjct: 73 GSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWAL 132 Query: 212 ERVLSGHHWDVKSCDWHP-EMGLIASASKDNLVKLWDPRSGNCISSI-LKFKHTVLKTRF 269 E+ GH V ++P + AS D VK+W ++ + V + Sbjct: 133 EQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDY 192 Query: 270 QP-TKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGS 328 P ++ S D + +++D + ++ +HP + DG+ Sbjct: 193 YPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPT-LPIIISGSEDGT 251 Query: 329 LKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGH--IFATAAKDRTIRFWTRARPIDPN 386 LK ++ E L + ++ +P G A+ + + Sbjct: 252 LKIWNSSTYKVEKTLNVGLERS---WCIATHPTGRKNYIASG--------FDNGFTVLSL 300 Query: 387 AYDDPTYN 394 D+PT + Sbjct: 301 GNDEPTLS 308 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 41/258 (15%), Positives = 101/258 (39%), Gaps = 6/258 (2%) Query: 127 FETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFS 186 + V + + W+++ G +++W + +R F Sbjct: 5 IKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFI 64 Query: 187 SNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW 246 + + + SDD ++++N++ G++ H ++S HP + S S D VKLW Sbjct: 65 ARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLW 124 Query: 247 DPRSGNCI-SSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELM-CVRDE 304 + + + + +H V+ F P + + D++ +V+ + S E Sbjct: 125 NWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQE 184 Query: 305 TDYMTLEWHPINESMF-TLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGH 363 ++++P+ + + A D ++K +D + + H ++ ++P Sbjct: 185 RGVNYVDYYPLPDKPYMITASDDLTIKIWDY---QTKSCVATLEGHMSNVSFAVFHPTLP 241 Query: 364 IFATAAKDRTIRFWTRAR 381 I + ++D T++ W + Sbjct: 242 IIISGSEDGTLKIWNSST 259 Score = 179 bits (453), Expect = 3e-45, Method: Composition-based stats. Identities = 56/332 (16%), Positives = 129/332 (38%), Gaps = 25/332 (7%) Query: 45 NRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPE 104 NR + + P + + + Y GR + N ++ S + + A ++ Sbjct: 11 NRSDRVKGIDFHPTEPWVLTTL----YSGRVELWNYETQVEVRSIQVTETPVRAGKFIAR 66 Query: 105 GRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQP 164 ++V + ++N ++ +AH + ++ +++SG D +K+W Sbjct: 67 KNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNW 126 Query: 165 NFS-MVKEIDAAHTESIRDMAFSSND-SKFVTCSDDNILKIWNFSNGKQERVL-SGHHWD 221 + +++ H + +AF+ D S F + D +K+W+ L +G Sbjct: 127 ENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERG 186 Query: 222 VKSCDW--HPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMA 279 V D+ P+ + +AS D +K+WD ++ +C++++ V F PT ++++ Sbjct: 187 VNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLP-IIIS 245 Query: 280 ISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLN 339 S+D + ++++ E + HP + + +D L + Sbjct: 246 GSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEP 305 Query: 340 EPILTIPYAHDKCITSLSYNPVGHIFATAAKD 371 +LS +PVG + + K+ Sbjct: 306 ---------------TLSLDPVGKLVWSGGKN 322 Score = 100 bits (250), Expect = 1e-21, Method: Composition-based stats. Identities = 34/173 (19%), Positives = 68/173 (39%), Gaps = 5/173 (2%) Query: 210 KQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRF 269 ++ S VK D+HP + + V+LW+ + + SI + V +F Sbjct: 4 DIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKF 63 Query: 270 QPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSL 329 K +++ S D RVF+ K + ++ HP + D ++ Sbjct: 64 IARKNWIIV-GSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVL-SGSDDLTV 121 Query: 330 KHFDLLQNLNEPILTIPYAHDKCITSLSYNP-VGHIFATAAKDRTIRFWTRAR 381 K ++ N + H+ + +++NP FA+ DRT++ W+ + Sbjct: 122 KLWNWENNWA--LEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQ 172 Score = 42.8 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 25/201 (12%), Positives = 54/201 (26%), Gaps = 26/201 (12%) Query: 10 QNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPN 69 I S +K + Q +S + + V P T+ I+ Sbjct: 197 DKPYMITASDDLTIKIWDYQTKSC------VATLEGHMSNVSFAVFHP----TLPIIISG 246 Query: 70 AYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEG--RRLVVATYSGEFSLWNASSFTF 127 + G ++ N + + N I P G + +G F++ + + Sbjct: 247 SEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNG-FTVLSLGNDEP 305 Query: 128 ETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIW---QPNFSMVKEIDAAHTESI---- 180 + V + +S + + I + + S+ Sbjct: 306 TLSL----DPVGKLVWSGGKN--AAASDIFTAVIRGNEEVEQDEPLSLQTKELGSVDVFP 359 Query: 181 RDMAFSSNDSKFVTCSDDNIL 201 + +A S N D + Sbjct: 360 QSLAHSPNGRFVTVVGDGEYV 380 Score = 28.9 bits (63), Expect = 4.7, Method: Composition-based stats. Identities = 4/43 (9%), Positives = 11/43 (25%) Query: 342 ILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPID 384 I + + ++P T + W ++ Sbjct: 5 IKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVE 47 >6HHQ-h nrPDB Length = 319 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 57/302 (18%), Positives = 117/302 (38%), Gaps = 22/302 (7%) Query: 47 RHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGR 106 G PNL++ T+ G D+ +P + S H++ T +G Sbjct: 26 SAGQPNLLLSASRDKTL---ISWKLTGDDQKFGVPVR----SFKGHSHIVQDCTLTADGA 78 Query: 107 RLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNF 166 + A++ LW+ ++ H S V ++ + +ISG D IK+W Sbjct: 79 YALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIISGSRDKTIKVWTIKG 138 Query: 167 SMVKEIDAAHTESIRDMAFSSNDS------KFVTCSDDNILKIWNFSNGKQERVLSGHHW 220 + + H + + + N+ ++ +D ++K WN + + E GH+ Sbjct: 139 QCLATLL-GHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQIEADFIGHNS 197 Query: 221 DVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAI 280 ++ + P+ LIASA KD + LW+ + + ++ + V F P + L A Sbjct: 198 NINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSA-QDEVFSLAFSPNRYWLAAAT 256 Query: 281 SKDKSCRVFDIRYSMKEL------MCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDL 334 + D +Y + +L E ++L W +++F D ++ + + Sbjct: 257 ATGIKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTLFA-GYTDNVIRVWQV 315 Query: 335 LQ 336 + Sbjct: 316 MT 317 Score = 174 bits (441), Expect = 6e-44, Method: Composition-based stats. Identities = 50/265 (18%), Positives = 111/265 (41%), Gaps = 18/265 (6%) Query: 126 TFETLMQAHDSAVTTMKYSHDS-DWMISGDADGMIKIW-----QPNFSMVKEIDAAHTES 179 ++ H+ VT++ S + ++S D + W F + H+ Sbjct: 8 VLRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHI 67 Query: 180 IRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASK 239 ++D +++ + ++ S D L++W+ + G+ + GH DV S D + +I S S+ Sbjct: 68 VQDCTLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDKKASMIISGSR 127 Query: 240 DNLVKLWDPRSGNCISSILKFKHTVLKTRFQPT-----KGNLLMAISKDKSCRVFDIRYS 294 D +K+W + G C++++L V + R P +++ DK + +++ Sbjct: 128 DKTIKVWTIK-GQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQF 186 Query: 295 MKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCIT 354 E + ++ TL P + ++ A DG + ++L L+ + Sbjct: 187 QIEADFIGHNSNINTLTASP-DGTLIASAGKDGEIMLWNLAAKKAMYTLSA----QDEVF 241 Query: 355 SLSYNPVGHIFATAAKDRTIRFWTR 379 SL+++P + A A I+ ++ Sbjct: 242 SLAFSPNRYWLAAATATG-IKVFSL 265 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 50/225 (22%), Positives = 94/225 (41%), Gaps = 18/225 (8%) Query: 168 MVKEIDAAHTESIRDMAFSSND-SKFVTCSDDNILKIWNFSNGKQ-----ERVLSGHHWD 221 +++ H + +A S+ + ++ S D L W + Q R GH Sbjct: 8 VLRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHI 67 Query: 222 VKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAIS 281 V+ C + SAS D ++LWD +G + K V+ K +++++ S Sbjct: 68 VQDCTLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDID-KKASMIISGS 126 Query: 282 KDKSCRVFDIRYSMKELMCVRDETDYMT-LEWHPINES-----MFTLACYDGSLKHFDLL 335 +DK+ +V+ I+ + L + D+++ + P ++ A D +K ++L Sbjct: 127 RDKTIKVWTIK--GQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLN 184 Query: 336 QNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRA 380 Q I H+ I +L+ +P G + A+A KD I W A Sbjct: 185 QF---QIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLA 226 Score = 82.5 bits (202), Expect = 4e-16, Method: Composition-based stats. Identities = 31/208 (14%), Positives = 72/208 (34%), Gaps = 21/208 (10%) Query: 14 QIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPET---SYTIDIMPPNA 70 I S+ +K + + + + + V P ++ I+ Sbjct: 122 IISGSRDKTIKVWT-------IKGQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGN 174 Query: 71 YRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETL 130 + NL I + +P+G + A GE LWN ++ Sbjct: 175 -DKMVKAWNLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYT 233 Query: 131 MQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMV----KEIDAAHTESIR----D 182 + A V ++ +S + W+ + A G IK++ + + + A ++++ Sbjct: 234 LSA-QDEVFSLAFSPNRYWLAAATATG-IKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVS 291 Query: 183 MAFSSNDSKFVTCSDDNILKIWNFSNGK 210 +A+S++ DN++++W Sbjct: 292 LAWSADGQTLFAGYTDNVIRVWQVMTAN 319 >4AEZ-A nrPDB Length = 401 Score = 187 bits (474), Expect = 9e-48, Method: Composition-based stats. Identities = 63/309 (20%), Positives = 121/309 (39%), Gaps = 11/309 (3%) Query: 76 RVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQA-H 134 R P + + + + W+ + VA +WNA S + L + Sbjct: 76 RFNTTPERVLDAPGIIDDYYLNLLDWS-NLNVVAVALE-RNVYVWNADSGSVSALAETDE 133 Query: 135 DSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVT 194 + V ++K+SHD ++ G +G++ I+ A H + ++++ + + Sbjct: 134 STYVASVKWSHDGSFLSVGLGNGLVDIYDVESQTKLRTMAGHQARVGCLSWNRH--VLSS 191 Query: 195 CSDDNILKIWNFSNGK-QERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNC 253 S + + Q L GH +V W + +AS DN+V++WD RS Sbjct: 192 GSRSGAIHHHDVRIANHQIGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIP 251 Query: 254 ISSILKFKHTVLKTRFQPTKGNLLMAIS--KDKSCRVFDIRYSMKELMCVRDETDYMTLE 311 + V + P + NLL DK ++ + + V + +L Sbjct: 252 KFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAATGAR-VNTVDAGSQVTSLI 310 Query: 312 WHPINESMFTLACY-DGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAK 370 W P ++ + + + D +L + + + IP AHD + + +P G I +TAA Sbjct: 311 WSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIP-AHDTRVLYSALSPDGRILSTAAS 369 Query: 371 DRTIRFWTR 379 D ++FW Sbjct: 370 DENLKFWRV 378 Score = 100 bits (250), Expect = 9e-22, Method: Composition-based stats. Identities = 31/196 (15%), Positives = 75/196 (38%), Gaps = 9/196 (4%) Query: 65 IMPPNAYRGRDRVINLPSKFTHLSSNK-VKHVIPAIQWTPEGRRLVVATYSGEFSLWNAS 123 ++ + G ++ + + + + + W +G +L +W+A Sbjct: 188 VLSSGSRSGAIHHHDVRIANHQIGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDAR 247 Query: 124 SFTFETLMQAHDSAVTTMKYSH-DSDWMISGD--ADGMIKIWQPNFSMVKEIDAAHTESI 180 S + H++AV + + S+ + +G D I W A ++ + Sbjct: 248 SSIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTVDAGSQ-V 306 Query: 181 RDMAFSSNDSKFVT--CSDDNILKIWNFSNGKQERV--LSGHHWDVKSCDWHPEMGLIAS 236 + +S + + ++ DN L IW++S+ + + H V P+ ++++ Sbjct: 307 TSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIPAHDTRVLYSALSPDGRILST 366 Query: 237 ASKDNLVKLWDPRSGN 252 A+ D +K W G+ Sbjct: 367 AASDENLKFWRVYDGD 382 Score = 75.9 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 35/244 (14%), Positives = 77/244 (31%), Gaps = 33/244 (13%) Query: 219 HWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHT-VLKTRFQPTKGNLL 277 + + DW + + + + V +W+ SG+ + + T V ++ G+ L Sbjct: 93 DYYLNLLDWS--NLNVVAVALERNVYVWNADSGSVSALAETDESTYVASVKWS-HDGSFL 149 Query: 278 MAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQN 337 + ++D+ K + L W N + + G++ H D+ Sbjct: 150 SVGLGNGLVDIYDVESQTKLRTMAGHQARVGCLSW---NRHVLSSGSRSGAIHHHDVRIA 206 Query: 338 LNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPI-------------- 383 ++ + H + L++ G A+ D ++ W I Sbjct: 207 NHQ--IGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAVKA 264 Query: 384 -------DPNAYDDPTYNNKKINGWFFGINNDINAVREKSEFGA---APPPPATLEPHAL 433 +K+I+ W +N V S+ + +P + H Sbjct: 265 VAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTVDAGSQVTSLIWSPHSKEIMSTHGF 324 Query: 434 PNMN 437 P+ N Sbjct: 325 PDNN 328 Score = 73.6 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 30/156 (19%), Positives = 56/156 (35%), Gaps = 8/156 (5%) Query: 66 MPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTP-EGRRLVVA--TYSGEFSLWNA 122 + ++ + S + + A+ W P + L T + WNA Sbjct: 232 LASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNA 291 Query: 123 SSFTFETLMQAHDSAVTTMKYSHDSDWMIS--GDADGMIKIWQPNFSMVKEI--DAAHTE 178 ++ + A VT++ +S S ++S G D + IW + S + + AH Sbjct: 292 ATGARVNTVDAGSQ-VTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIPAHDT 350 Query: 179 SIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERV 214 + A S + T + D LK W +G + Sbjct: 351 RVLYSALSPDGRILSTAASDENLKFWRVYDGDHVKR 386 >6GMH-W nrPDB Length = 305 Score = 184 bits (468), Expect = 5e-47, Method: Composition-based stats. Identities = 59/286 (20%), Positives = 122/286 (42%), Gaps = 10/286 (3%) Query: 7 NQYQN-QNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDI 65 N+ +N + + S +K + + +D+ + G VV + S+T+ I Sbjct: 27 NKKENSETVVTGSLDDLVKVWKWRDERLDLQWSL----EGHQLG----VVSVDISHTLPI 78 Query: 66 MPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSF 125 ++ R+ +L + S + + ++P+ + L T+ G+ +++ S Sbjct: 79 AASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESG 138 Query: 126 TFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAF 185 E + + ++ YS D ++ SG DG+I I+ + H IR + F Sbjct: 139 KKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTF 198 Query: 186 SSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKL 245 S + VT SDD +KI++ + LSGH V + + P+ S+S D VK+ Sbjct: 199 SPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKV 258 Query: 246 WDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDI 291 WD + C+ + + V ++ G+ ++++ D+ ++D Sbjct: 259 WDVGTRTCVHTFFDHQDQVWGVKYN-GNGSKIVSVGDDQEIHIYDC 303 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 48/293 (16%), Positives = 109/293 (37%), Gaps = 11/293 (3%) Query: 92 VKHVIPAIQWTPEGRR----LVVATYSGEFSLWNASS--FTFETLMQAHDSAVTTMKYSH 145 I ++ W + +V + +W + ++ H V ++ SH Sbjct: 15 HDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISH 74 Query: 146 DSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWN 205 S D I++W + A +AFS + T + + I+ Sbjct: 75 TLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFG 134 Query: 206 FSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVL 265 +GK+E L + S + P+ +AS + D ++ ++D +G + ++ + Sbjct: 135 VESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIR 194 Query: 266 KTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACY 325 F P LL+ S D +++D++++ + + + + P +++ F + Sbjct: 195 SLTFSP-DSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCP-DDTHFVSSSS 252 Query: 326 DGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWT 378 D S+K +D+ + + H + + YN G + D+ I + Sbjct: 253 DKSVKVWDVGTRT---CVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 49/222 (22%), Positives = 92/222 (41%), Gaps = 11/222 (4%) Query: 165 NFSMVKEIDAAHTESIRDMAFSSNDSK----FVTCSDDNILKIWNFSNGKQERVLS--GH 218 + ++ + + AH ++I +A+ +N + VT S D+++K+W + + + + S GH Sbjct: 4 QYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGH 63 Query: 219 HWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLM 278 V S D + + AS+S D ++LWD +G I SI F P L Sbjct: 64 QLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSP-DSQYLA 122 Query: 279 AISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNL 338 + +F + KE +++ + P + DG + FD+ Sbjct: 123 TGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSP-DGKYLASGAIDGIINIFDIATG- 180 Query: 339 NEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRA 380 +L H I SL+++P + TA+ D I+ + Sbjct: 181 --KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQ 220 Score = 33.2 bits (74), Expect = 0.27, Method: Composition-based stats. Identities = 9/48 (18%), Positives = 17/48 (35%), Gaps = 4/48 (8%) Query: 335 LQNLNEPILTIPYAHDKCITSLSY----NPVGHIFATAAKDRTIRFWT 378 + N + AHD I S+++ T + D ++ W Sbjct: 1 MTNQYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWK 48 >5OQL-d nrPDB Length = 446 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 62/298 (20%), Positives = 119/298 (39%), Gaps = 19/298 (6%) Query: 129 TLMQAHDSAVTTMKYSHDS-DWMISGDADGMIKIWQPNFSMVKEID-AAHTESIRDMAFS 186 L H V +M +S + + SG DG++K+W + AAH ++ + F Sbjct: 60 QLGNGHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTF- 118 Query: 187 SNDSKFVTCSDDNILKIWNF----SNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNL 242 +ND K ++C+ D +K+W+ SN S +H A++S Sbjct: 119 TNDKKLLSCATDG-IKLWDPYASPSNTTPIATWQE-GGPYTSLSFHRSANTFAASSGQGC 176 Query: 243 VKLWDPRSGNCISSILK--FKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMC 300 +++WD +I F T+ F + +++ +++ D+S +FD+R +M + Sbjct: 177 IRIWDLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKT 236 Query: 301 VRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNP 360 V + ++P+ +A D ++ FD + L I H + + ++P Sbjct: 237 VLHFA-CNRIVFNPMEAMNLAVASEDHNIYIFDARNF--DKALNIQKGHVAAVMDVEFSP 293 Query: 361 VGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNK-----KINGWFFGINNDINAVR 413 G + + DRTIR W R + Y ++ + +D VR Sbjct: 294 TGEELVSGSYDRTIRLWRRDAGHSRDVYHTKRMQRVFRTMWTMDSKYILTGSDDGNVR 351 Score = 112 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 40/300 (13%), Positives = 97/300 (32%), Gaps = 22/300 (7%) Query: 16 QQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRD 75 S +K + R + + + L + Sbjct: 84 SGSGDGVVKVWDLTTRDEETW-----RVAAHNNIVKGLTFT-NDKKLLSCATDG-----I 132 Query: 76 RVIN---LPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQ 132 ++ + PS T +++ + ++ + ++ G +W+ T +Q Sbjct: 133 KLWDPYASPSNTTPIATWQEGGPYTSLSFHRSANTFAASSGQGCIRIWDLEHSTAGQAIQ 192 Query: 133 AHD--SAVTTMKYSH-DSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSS-N 188 +T + ++ ++ + S D I ++ +M H + + F+ Sbjct: 193 WPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLHF-ACNRIVFNPME 251 Query: 189 DSKFVTCSDDNILKIWNFSN-GKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWD 247 S+D+ + I++ N K + GH V ++ P + S S D ++LW Sbjct: 252 AMNLAVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPTGEELVSGSYDRTIRLWR 311 Query: 248 PRSGNCISS-ILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETD 306 +G+ K V +T + ++ S D + R++ S + + + Sbjct: 312 RDAGHSRDVYHTKRMQRVFRTMWT-MDSKYILTGSDDGNVRLWRANASERSGVKATRQRQ 370 >4BTS-AR nrPDB Length = 343 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 50/308 (16%), Positives = 104/308 (33%), Gaps = 36/308 (11%) Query: 64 DIMPPNAYRGRDRVINLPSKFT-------HLSSNKVKHVIPAIQWTPEGRRLVVATYSGE 116 ++ + + L + H + H + + + E + +++ Sbjct: 40 PVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLALSQENCFAISSSWDKT 99 Query: 117 FSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEI--DA 174 LW+ + T H S V ++ +S D+ ++S A+ IK+W Sbjct: 100 LRLWDLRTGTTYKRFVGHQSEVYSVAFSPDNRQILSAGAEREIKLWNILGECKFSSAEKE 159 Query: 175 AHTESIRDMAFS----------SNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKS 224 H++ + + +S F + D LK+WN N + H +V Sbjct: 160 NHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWNT-NFQIRYTFKAHESNVNH 218 Query: 225 CDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDK 284 P IA+ KD + +WD + T+ + F P +A+ D+ Sbjct: 219 LSISPNGKYIATGGKDKKLLIWDILNLTYPQREFDAGSTINQIAFNPKLQW--VAVGTDQ 276 Query: 285 SCRVFDIRYSMKELMCV-------------RDETDYMTLEWHPINESMFTLACYDGSLKH 331 ++F++ K +C +L W+ + + +F DG ++ Sbjct: 277 GVKIFNLMTQSKAPVCTIEAEPITKAEGQKGKNPQCTSLAWNALGKKLFA-GFTDGVIRT 335 Query: 332 FDLLQNLN 339 F + N Sbjct: 336 FSFETSAN 343 Score = 166 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 57/278 (20%), Positives = 102/278 (36%), Gaps = 30/278 (10%) Query: 126 TFETLMQAHDSAVTTM------KYSHDSDWMISGDADGMIKIW-------QPNFSMVKEI 172 +++ H VT++ K + DS +ISG D + IW F + + Sbjct: 12 VKRGILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKA 71 Query: 173 DAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMG 232 H + D+A S + ++ S D L++W+ G + GH +V S + P+ Sbjct: 72 LTGHNHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSPDNR 131 Query: 233 LIASASKDNLVKLWDPRSGNCISSILK--FKHTVLKTRFQP---------TKGNLLMAIS 281 I SA + +KLW+ SS K V R+ P ++ Sbjct: 132 QILSAGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVG 191 Query: 282 KDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEP 341 D +V++ + ++ E++ L P N D L +D+L NL P Sbjct: 192 WDGRLKVWNTNFQIRYTFK-AHESNVNHLSISP-NGKYIATGGKDKKLLIWDIL-NLTYP 248 Query: 342 ILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTR 379 I +++NP A D+ ++ + Sbjct: 249 QREFDAG--STINQIAFNPKLQWVA-VGTDQGVKIFNL 283 Score = 160 bits (405), Expect = 1e-39, Method: Composition-based stats. Identities = 50/306 (16%), Positives = 101/306 (33%), Gaps = 33/306 (10%) Query: 102 TPEGRRLVVATYSGEFSLW-------NASSFTFETLMQAHDSAVTTMKYSHDSDWMISGD 154 + L+ + +W N + H+ V+ + S ++ + IS Sbjct: 36 NEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLALSQENCFAISSS 95 Query: 155 ADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERV 214 D +++W + H + +AFS ++ + ++ + +K+WN + Sbjct: 96 WDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSPDNRQILSAGAEREIKLWNILGECKFSS 155 Query: 215 --LSGHHWDVKSCDWHPEMG----------LIASASKDNLVKLWDPRSGNCISSILKFKH 262 H V + P M AS D +K+W+ + + Sbjct: 156 AEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWNTNF-QIRYTFKAHES 214 Query: 263 TVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTL 322 V P G + KDK ++DI + + ++P + + Sbjct: 215 NVNHLSISP-NGKYIATGGKDKKLLIWDILNLTYPQREFDAGSTINQIAFNP--KLQWVA 271 Query: 323 ACYDGSLKHFDLLQNLNEPILTI----------PYAHDKCITSLSYNPVGHIFATAAKDR 372 D +K F+L+ P+ TI + TSL++N +G D Sbjct: 272 VGTDQGVKIFNLMTQSKAPVCTIEAEPITKAEGQKGKNPQCTSLAWNALGKKLFAGFTDG 331 Query: 373 TIRFWT 378 IR ++ Sbjct: 332 VIRTFS 337 Score = 110 bits (274), Expect = 2e-24, Method: Composition-based stats. Identities = 36/222 (16%), Positives = 76/222 (34%), Gaps = 29/222 (13%) Query: 214 VLSGHHWDVKSCD--WHP----EMGLIASASKDNLVKLWDPRS-------GNCISSILKF 260 +L GH V S + + ++ S S+D V +W G ++ Sbjct: 16 ILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGH 75 Query: 261 KHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMF 320 H V + ++ S DK+ R++D+R V +++ ++ + P + Sbjct: 76 NHFVSDLALS-QENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSP-DNRQI 133 Query: 321 TLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGH----------IFATAAK 370 A + +K +++L + H ++ + Y+P+ FA+ Sbjct: 134 LSAGAEREIKLWNIL-GECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGW 192 Query: 371 DRTIRFWTRARPID-PNAYDDPTYNNKKI--NGWFFGINNDI 409 D ++ W I + N+ I NG + Sbjct: 193 DGRLKVWNTNFQIRYTFKAHESNVNHLSISPNGKYIATGGKD 234 Score = 100 bits (249), Expect = 1e-21, Method: Composition-based stats. Identities = 39/264 (14%), Positives = 87/264 (32%), Gaps = 43/264 (16%) Query: 9 YQNQNQIQQSQQPPLKKYVTQRRSVDVSS-PYINLYYNRRHGLPNLVVEPETSYTIDIMP 67 +N I S L+ + D+ + + + + ++ P+ + Sbjct: 86 QENCFAISSSWDKTLRLW-------DLRTGTTYKRFVGHQSEVYSVAFSPDNRQILSAGA 138 Query: 68 PNAYRGRDRVINL--PSKFTHLSSNKVKHVIPAIQWTPEGR----------RLVVATYSG 115 ++ N+ KF+ + ++++P + + G Sbjct: 139 ER----EIKLWNILGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDG 194 Query: 116 EFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQP--NFSMVKEID 173 +WN ++F +AH+S V + S + ++ +G D + IW +E D Sbjct: 195 RLKVWN-TNFQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKLLIWDILNLTYPQREFD 253 Query: 174 AAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERV-------------LSGHHW 220 A +I +AF+ V D +KI+N + V G + Sbjct: 254 AG--STINQIAFNPKLQW-VAVGTDQGVKIFNLMTQSKAPVCTIEAEPITKAEGQKGKNP 310 Query: 221 DVKSCDWHPEMGLIASASKDNLVK 244 S W+ + + D +++ Sbjct: 311 QCTSLAWNALGKKLFAGFTDGVIR 334 >5Z56-q nrPDB Length = 504 Score = 177 bits (449), Expect = 7e-45, Method: Composition-based stats. Identities = 44/287 (15%), Positives = 105/287 (36%), Gaps = 9/287 (3%) Query: 96 IPAIQWTP-EGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGD 154 I A+ P + +++ +++ SS ++ H VT++ + D + S Sbjct: 224 ILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSAS 283 Query: 155 ADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERV 214 D I+IW + ++ AH ++ ++ + ++ SDD + G+ Sbjct: 284 PDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTK 343 Query: 215 LSGHHW--DVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPT 272 ++ + +HP+ + + + D+ +K+WD + +++ + F Sbjct: 344 VTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFS-E 402 Query: 273 KGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHF 332 G L + D S +++D+R D + + + L D + Sbjct: 403 NGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYI- 461 Query: 333 DLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTR 379 IL H T +++ A+ DR+++F++ Sbjct: 462 ---CKQWTEILHFTE-HSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 51/199 (25%), Positives = 93/199 (46%), Gaps = 9/199 (4%) Query: 186 SSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKL 245 S+ +K +T D + +++ S+ + L GH V S +HP L+ SAS D +++ Sbjct: 231 PSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRI 290 Query: 246 WDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDET 305 W + +C+ + + V T G+ L++ S D+ DI+ + L V DET Sbjct: 291 WSVPNASCVQVVRAHESAVTGLSLHAT-GDYLLSSSDDQYWAFSDIQTG-RVLTKVTDET 348 Query: 306 D---YMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVG 362 ++HP + +F D +K +DL + N + H ITS++++ G Sbjct: 349 SGCSLTCAQFHP-DGLIFGTGTMDSQIKIWDLKERTN---VANFPGHSGPITSIAFSENG 404 Query: 363 HIFATAAKDRTIRFWTRAR 381 + ATAA D +++ W + Sbjct: 405 YYLATAADDSSVKLWDLRK 423 Score = 149 bits (375), Expect = 3e-36, Method: Composition-based stats. Identities = 48/269 (17%), Positives = 91/269 (33%), Gaps = 7/269 (2%) Query: 69 NAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFE 128 V + S+ + + ++ + P + A+ +W+ + + Sbjct: 240 GGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCV 299 Query: 129 TLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTE--SIRDMAFS 186 +++AH+SAVT + D+++S D V T S+ F Sbjct: 300 QVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFH 359 Query: 187 SNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW 246 + F T + D+ +KIW+ GH + S + +A+A+ D+ VKLW Sbjct: 360 PDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLW 419 Query: 247 DPRSGNCISSILKFKH-TVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDET 305 D R ++ + V F G L D + E++ + + Sbjct: 420 DLRKLKNFKTLQLDNNFEVKSLIFD-QSGTYLALGGTDVQIYICK---QWTEILHFTEHS 475 Query: 306 DYMTLEWHPINESMFTLACYDGSLKHFDL 334 T + D SLK + L Sbjct: 476 GLTTGVAFGHHAKFIASTGMDRSLKFYSL 504 Score = 131 bits (328), Expect = 8e-31, Method: Composition-based stats. Identities = 40/249 (16%), Positives = 86/249 (34%), Gaps = 10/249 (4%) Query: 46 RRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEG 105 + ++V P P R+ ++P+ + + + G Sbjct: 263 HTKKVTSVVFHPSQDLVFSASP----DATIRIWSVPNASCVQVVRAHESAVTGLSLHATG 318 Query: 106 RRLVVATYSGEFSLWNASSFTFETLMQAHDSAV--TTMKYSHDSDWMISGDADGMIKIWQ 163 L+ ++ ++ + + T + S T ++ D +G D IKIW Sbjct: 319 DYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWD 378 Query: 164 PNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLS-GHHWDV 222 H+ I +AFS N T +DD+ +K+W+ K + L ++++V Sbjct: 379 LKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEV 438 Query: 223 KSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISK 282 KS + +A D V+++ + I + F + + Sbjct: 439 KSLIFDQSGTYLALGGTD--VQIYICKQWTEILHFTEHSGLTTGVAF-GHHAKFIASTGM 495 Query: 283 DKSCRVFDI 291 D+S + + + Sbjct: 496 DRSLKFYSL 504 Score = 104 bits (260), Expect = 7e-23, Method: Composition-based stats. Identities = 37/220 (16%), Positives = 77/220 (35%), Gaps = 16/220 (7%) Query: 205 NFSNGKQERVLSGHHW----DVKSCDWHP-EMGLIASASKDNLVKLWDPRSGNCISSILK 259 S +Q G H + + D P + I + D V ++D S ++++ Sbjct: 203 ELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKG 262 Query: 260 FKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESM 319 V F P++ +L+ + S D + R++ + + + E+ L H + + Sbjct: 263 HTKKVTSVVFHPSQ-DLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYL 321 Query: 320 FTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCI--TSLSYNPVGHIFATAAKDRTIRFW 377 + D +++ +LT T ++P G IF T D I+ W Sbjct: 322 L-SSSDD---QYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIW 377 Query: 378 TRAR--PIDPNAYDDPTYNNKKI--NGWFFGINNDINAVR 413 + + NG++ D ++V+ Sbjct: 378 DLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVK 417 >5L9T-R nrPDB Length = 493 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 55/311 (17%), Positives = 117/311 (37%), Gaps = 15/311 (4%) Query: 76 RVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETL--MQA 133 ++ +P K + + + W+ ++ LW+A + L + Sbjct: 170 KISKIPFKVLDAPELQDDFYLNLVDWSSLN--VLSVGLGTCVYLWSACTSQVTRLCDLSV 227 Query: 134 HDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFV 193 +VT++ +S + + G G ++IW + HT + +A+++ + Sbjct: 228 EGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAE--QLS 285 Query: 194 TCSDDNILKIWNFSNG--KQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSG 251 + S D ++ + + ER L GH +V W + L+AS DN + +W+ S Sbjct: 286 SGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSL 345 Query: 252 NCISSILKFKHTVLKTRFQPTKGNLLMAIS--KDKSCRVFDIRYSMKELMCVRDETDYMT 309 + + + V + P + LL + D+ R ++ + + L C+ + Sbjct: 346 SPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNT-LTGQPLQCIDTGSQVCN 404 Query: 310 LEWHPINESMFTLACYD-GSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATA 368 L W + + Y + + + + + H + L+ +P G T Sbjct: 405 LAWSKHANELVSTHGYSQNQILVW---KYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTG 461 Query: 369 AKDRTIRFWTR 379 A D T+RFW Sbjct: 462 AGDETLRFWNV 472 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 37/252 (14%), Positives = 88/252 (34%), Gaps = 11/252 (4%) Query: 54 VVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATY 113 V S +++ ++G ++ + + + A+ W E L + Sbjct: 232 VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ--LSSGSR 289 Query: 114 SGEFSLWNASS--FTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKE 171 + + E +Q H V +K+S D + SG D + +W + + Sbjct: 290 DRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQ 349 Query: 172 IDAAHTESIRDMAFSSNDSKFVTCS---DDNILKIWNFSNGKQERVLSGHHWDVKSCDWH 228 H +++ +A+S + + D ++ WN G+ + + V + W Sbjct: 350 QYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT-GSQVCNLAWS 408 Query: 229 PEMGLIAS--ASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSC 286 + S N + +W S ++ + + VL P G ++ + D++ Sbjct: 409 KHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSP-DGEAIVTGAGDETL 467 Query: 287 RVFDIRYSMKEL 298 R +++ + Sbjct: 468 RFWNVFSKTRST 479 Score = 64.8 bits (156), Expect = 8e-11, Method: Composition-based stats. Identities = 24/176 (13%), Positives = 45/176 (25%), Gaps = 16/176 (9%) Query: 1 MDGHNQN------QYQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLV 54 + GH Q +Q L + S + Y + + Sbjct: 309 LQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSP------VQQYTEHLAAVKAIA 362 Query: 55 VEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVV--AT 112 P + R N + L + + W+ LV Sbjct: 363 WSPHQHGLLAS-GGGTADRCIRFWNTLT-GQPLQCIDTGSQVCNLAWSKHANELVSTHGY 420 Query: 113 YSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSM 168 + +W S T + H V + S D + +++G D ++ W Sbjct: 421 SQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKT 476 Score = 37.4 bits (85), Expect = 0.015, Method: Composition-based stats. Identities = 14/153 (9%), Positives = 47/153 (30%), Gaps = 6/153 (3%) Query: 265 LKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLAC 324 K L+ + + ++ I + + + ++D+ ++W +N Sbjct: 148 YSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLN---VLSVG 204 Query: 325 YDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRA--RP 382 + + + + + D +TS+ ++ G++ A ++ W A + Sbjct: 205 LGTCVYLWSACTSQVTRLCDLSVEGDS-VTSVGWSERGNLVAVGTHKGFVQIWDAAAGKK 263 Query: 383 IDPNAYDDPTYNNKKINGWFFGINNDINAVREK 415 + N + + ++ Sbjct: 264 LSMLEGHTARVGALAWNAEQLSSGSRDRMILQR 296 >2HES-X nrPDB Length = 330 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 61/313 (19%), Positives = 114/313 (36%), Gaps = 32/313 (10%) Query: 100 QWTPEGRRLVVATYSGEFSL----WNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDA 155 + L + + L ++ + AH A+ ++ + + + +G Sbjct: 19 SFDFSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSF 78 Query: 156 DGMIKIWQPNFSMVKEID-------AAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSN 208 D + IW S + + H ++ +A+S++ TCS D + IW Sbjct: 79 DSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDE 138 Query: 209 G----KQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWD--PRSGNCISSILKFKH 262 + VL H DVK WHP L+AS+S D+ V++W C++ + + Sbjct: 139 SGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDDWECVAVLNGHEG 198 Query: 263 TVLKTRFQPTKGNL-LMAISKDKSCRVF----DIRYSMKELMCVR-----DETDYMTLEW 312 TV + F T+G L + S D + RV+ D +E +C + + W Sbjct: 199 TVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAW 258 Query: 313 HPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAH-DKCITSLSYNPVG--HIFATAA 369 + DG L ++ + + H I + + + I AT Sbjct: 259 --GFNGLIASVGADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVKWLELNGKTILATGG 316 Query: 370 KDRTIRFWTRARP 382 D + FW+ + Sbjct: 317 DDGIVNFWSLEKA 329 Score = 141 bits (356), Expect = 5e-34, Method: Composition-based stats. Identities = 47/305 (15%), Positives = 117/305 (38%), Gaps = 35/305 (11%) Query: 65 IMPPNAYRGRDRVINLP----SKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLW 120 I+ + + +++++ + L K I ++ W P L ++ S+W Sbjct: 26 ILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSFDSTVSIW 85 Query: 121 NASSF-------TFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFS----MV 169 +++ H++ V + +S+D ++ + D + IW+ + S Sbjct: 86 AKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYEC 145 Query: 170 KEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIW-NFSNG-KQERVLSGHHWDVKSCDW 227 + H++ ++ + + +++ + S D+ ++IW ++ + + VL+GH V S D+ Sbjct: 146 ISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDF 205 Query: 228 HPEMGLI--ASASKDNLVKLW--------DPRSGNCISSILK-FKHTVLKTRFQPTKGNL 276 G+ S S D+ V++W D + C + + K V + L Sbjct: 206 DKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFN--GL 263 Query: 277 LMAISKDKSCRVF-----DIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKH 331 + ++ D V+ + + K +C + +++ DG + Sbjct: 264 IASVGADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVKWLELNGKTILATGGDDGIVNF 323 Query: 332 FDLLQ 336 + L + Sbjct: 324 WSLEK 328 Score = 73.2 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 26/144 (18%), Positives = 59/144 (40%), Gaps = 12/144 (8%) Query: 252 NCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETD----Y 307 N I S+ +K + F +L S D+ ++ ++Y L+ V DET Sbjct: 5 NLIKSLKLYKEKIWSFDFS---QGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAI 61 Query: 308 MTLEWHPINESMFTLACYDGSLKHF----DLLQNLNEPILTIPYAHDKCITSLSYNPVGH 363 ++ W P + S+ +D ++ + + +L I H+ + ++++ G+ Sbjct: 62 RSVAWRP-HTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGY 120 Query: 364 IFATAAKDRTIRFWTRARPIDPNA 387 AT ++D+++ W + Sbjct: 121 YLATCSRDKSVWIWETDESGEEYE 144 >4LG8-A nrPDB Length = 354 Score = 175 bits (443), Expect = 5e-44, Method: Composition-based stats. Identities = 44/287 (15%), Positives = 105/287 (36%), Gaps = 9/287 (3%) Query: 96 IPAIQWTP-EGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGD 154 I A+ P + +++ +++ SS ++ H VT++ + D + S Sbjct: 74 ILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSAS 133 Query: 155 ADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERV 214 D I+IW + ++ AH ++ ++ + ++ SDD + G+ Sbjct: 134 PDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTK 193 Query: 215 LSGHHW--DVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPT 272 ++ + +HP+ + + + D+ +K+WD + +++ + F Sbjct: 194 VTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFS-E 252 Query: 273 KGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHF 332 G L + D S +++D+R D + + + L D + Sbjct: 253 NGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYI- 311 Query: 333 DLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTR 379 IL H T +++ A+ DR+++F++ Sbjct: 312 ---CKQWTEILHFTE-HSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 354 Score = 154 bits (389), Expect = 7e-38, Method: Composition-based stats. Identities = 51/199 (25%), Positives = 93/199 (46%), Gaps = 9/199 (4%) Query: 186 SSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKL 245 S+ +K +T D + +++ S+ + L GH V S +HP L+ SAS D +++ Sbjct: 81 PSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRI 140 Query: 246 WDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDET 305 W + +C+ + + V T G+ L++ S D+ DI+ + L V DET Sbjct: 141 WSVPNASCVQVVRAHESAVTGLSLHAT-GDYLLSSSDDQYWAFSDIQTG-RVLTKVTDET 198 Query: 306 D---YMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVG 362 ++HP + +F D +K +DL + N + H ITS++++ G Sbjct: 199 SGCSLTCAQFHP-DGLIFGTGTMDSQIKIWDLKERTN---VANFPGHSGPITSIAFSENG 254 Query: 363 HIFATAAKDRTIRFWTRAR 381 + ATAA D +++ W + Sbjct: 255 YYLATAADDSSVKLWDLRK 273 Score = 147 bits (370), Expect = 1e-35, Method: Composition-based stats. Identities = 48/269 (17%), Positives = 91/269 (33%), Gaps = 7/269 (2%) Query: 69 NAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFE 128 V + S+ + + ++ + P + A+ +W+ + + Sbjct: 90 GGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCV 149 Query: 129 TLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTE--SIRDMAFS 186 +++AH+SAVT + D+++S D V T S+ F Sbjct: 150 QVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFH 209 Query: 187 SNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW 246 + F T + D+ +KIW+ GH + S + +A+A+ D+ VKLW Sbjct: 210 PDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLW 269 Query: 247 DPRSGNCISSILKFKH-TVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDET 305 D R ++ + V F G L D + E++ + + Sbjct: 270 DLRKLKNFKTLQLDNNFEVKSLIFD-QSGTYLALGGTDVQIYICK---QWTEILHFTEHS 325 Query: 306 DYMTLEWHPINESMFTLACYDGSLKHFDL 334 T + D SLK + L Sbjct: 326 GLTTGVAFGHHAKFIASTGMDRSLKFYSL 354 Score = 129 bits (323), Expect = 3e-30, Method: Composition-based stats. Identities = 40/249 (16%), Positives = 86/249 (34%), Gaps = 10/249 (4%) Query: 46 RRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEG 105 + ++V P P R+ ++P+ + + + G Sbjct: 113 HTKKVTSVVFHPSQDLVFSASP----DATIRIWSVPNASCVQVVRAHESAVTGLSLHATG 168 Query: 106 RRLVVATYSGEFSLWNASSFTFETLMQAHDSAV--TTMKYSHDSDWMISGDADGMIKIWQ 163 L+ ++ ++ + + T + S T ++ D +G D IKIW Sbjct: 169 DYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWD 228 Query: 164 PNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLS-GHHWDV 222 H+ I +AFS N T +DD+ +K+W+ K + L ++++V Sbjct: 229 LKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEV 288 Query: 223 KSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISK 282 KS + +A D V+++ + I + F + + Sbjct: 289 KSLIFDQSGTYLALGGTD--VQIYICKQWTEILHFTEHSGLTTGVAF-GHHAKFIASTGM 345 Query: 283 DKSCRVFDI 291 D+S + + + Sbjct: 346 DRSLKFYSL 354 Score = 102 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 37/220 (16%), Positives = 77/220 (35%), Gaps = 16/220 (7%) Query: 205 NFSNGKQERVLSGHHW----DVKSCDWHP-EMGLIASASKDNLVKLWDPRSGNCISSILK 259 S +Q G H + + D P + I + D V ++D S ++++ Sbjct: 53 ELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKG 112 Query: 260 FKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESM 319 V F P++ +L+ + S D + R++ + + + E+ L H + + Sbjct: 113 HTKKVTSVVFHPSQ-DLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYL 171 Query: 320 FTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCI--TSLSYNPVGHIFATAAKDRTIRFW 377 + D +++ +LT T ++P G IF T D I+ W Sbjct: 172 L-SSSDD---QYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIW 227 Query: 378 TRAR--PIDPNAYDDPTYNNKKI--NGWFFGINNDINAVR 413 + + NG++ D ++V+ Sbjct: 228 DLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVK 267 >3JAP-g nrPDB Length = 326 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 56/311 (18%), Positives = 104/311 (33%), Gaps = 28/311 (9%) Query: 92 VKHVIPAIQWTPEG-RRLVVATYSGEFSLWNA-----SSFTFETLMQAHDSAVTTMKYSH 145 + ++ + LV + W + H V + S Sbjct: 17 HNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDVVVSA 76 Query: 146 DSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWN 205 D ++ +S D +++W + HT + +A +N SK ++ S D +++WN Sbjct: 77 DGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIISASRDKTIRVWN 136 Query: 206 FSNGKQERVLSGHHWDVKSCDWHPEMG----------LIASASKDNLVKLW--DPRSGNC 253 G VL GH V P+ SA D +V+ W + S Sbjct: 137 TV-GDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWSLNEDSYRI 195 Query: 254 ISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWH 313 + + + + + P G+L + KD V+++++ M + + L + Sbjct: 196 EADFIGHNNYINVVQPSP-DGSLAASAGKDGQIYVWNLKH-KSAFMNFDAKDEVFALAFS 253 Query: 314 PINESMFTLACYDGSLKHFDLLQNLNEPILT-----IPYAHDKCITSLSYNPVGHIFATA 368 P + A +K +DL + L A D SL+++ G Sbjct: 254 PS--RFWLTAATASGIKIYDLENEVLIDELKPEFAGYTKAQDPHAVSLAWSADGQTLFAG 311 Query: 369 AKDRTIRFWTR 379 D IR W Sbjct: 312 YTDNVIRVWQV 322 Score = 168 bits (425), Expect = 5e-42, Method: Composition-based stats. Identities = 52/310 (16%), Positives = 114/310 (36%), Gaps = 32/310 (10%) Query: 47 RHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGR 106 PNL+V T+ ++ +P + S H++ + + +G Sbjct: 27 SAAQPNLLVSGSRDKTL---ISWRLTENEQQFGVPVR----SYKGHSHIVQDVVVSADGN 79 Query: 107 RLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNF 166 V A++ LWN ++ E H V ++ +S +IS D I++W Sbjct: 80 YAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIISASRDKTIRVWN-TV 138 Query: 167 SMVKEIDAAHTESIRDMAFSSNDSK----------FVTCSDDNILKIWNF--SNGKQERV 214 + HT+ + + + + + FV+ D I++ W+ + + E Sbjct: 139 GDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWSLNEDSYRIEAD 198 Query: 215 LSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKG 274 GH+ + P+ L ASA KD + +W+ + + + K V F P++ Sbjct: 199 FIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMNFDA-KDEVFALAFSPSRF 257 Query: 275 NLLMAISKDKSCRVFDIRYSM--------KELMCVRDETDYMTLEWHPINESMFTLACYD 326 L A + +++D+ + + ++L W +++F D Sbjct: 258 WLTAATAS--GIKIYDLENEVLIDELKPEFAGYTKAQDPHAVSLAWSADGQTLFA-GYTD 314 Query: 327 GSLKHFDLLQ 336 ++ + ++ Sbjct: 315 NVIRVWQVMT 324 Score = 164 bits (414), Expect = 1e-40, Method: Composition-based stats. Identities = 54/275 (19%), Positives = 106/275 (38%), Gaps = 24/275 (8%) Query: 126 TFETLMQAHDSAVTTMKYSHDS-DWMISGDADGMIKIW-----QPNFSMVKEIDAAHTES 179 ++ H+ VT++ S + ++SG D + W + F + H+ Sbjct: 9 VLRGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHI 68 Query: 180 IRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASK 239 ++D+ S++ + V+ S D L++WN + G E GH DV S I SAS+ Sbjct: 69 VQDVVVSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIISASR 128 Query: 240 DNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGN---------LLMAISKDKSCRVFD 290 D +++W+ G+C +L V K R P ++ DK R + Sbjct: 129 DKTIRVWNT-VGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWS 187 Query: 291 IRYSMKELM--CVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYA 348 + + + ++ P + S+ A DG + + NL + + Sbjct: 188 LNEDSYRIEADFIGHNNYINVVQPSP-DGSLAASAGKDGQIYVW----NLKHKSAFMNFD 242 Query: 349 HDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPI 383 + +L+++P + TAA I+ + + Sbjct: 243 AKDEVFALAFSP-SRFWLTAATASGIKIYDLENEV 276 Score = 72.1 bits (175), Expect = 5e-13, Method: Composition-based stats. Identities = 37/226 (16%), Positives = 73/226 (32%), Gaps = 19/226 (8%) Query: 1 MDGHNQN------QYQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLV 54 GH + + I S+ ++ + T V + + R NL Sbjct: 104 FVGHTGDVLSVAIDANSSKIISASRDKTIRVWNTVGDCAYVLLGHTDWVTKVRVAPKNLE 163 Query: 55 VEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLS--SNKVKHVIPAIQWTPEGRRLVVAT 112 + E R +L + + I +Q +P+G A Sbjct: 164 -DGEVDDGRITFVSAGMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAG 222 Query: 113 YSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMV--- 169 G+ +WN + A V + +S W+ + A G IKI+ ++ Sbjct: 223 KDGQIYVWNLKHKSAFMNFDA-KDEVFALAFSPSRFWLTAATASG-IKIYDLENEVLIDE 280 Query: 170 -KEIDAAHTES----IRDMAFSSNDSKFVTCSDDNILKIWNFSNGK 210 K A +T++ +A+S++ DN++++W Sbjct: 281 LKPEFAGYTKAQDPHAVSLAWSADGQTLFAGYTDNVIRVWQVMTAN 326 >5WYK-BB nrPDB Length = 943 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 64/328 (19%), Positives = 126/328 (38%), Gaps = 25/328 (7%) Query: 71 YRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETL 130 Y RD P K + + + +I + + + L A+ +G +WN + Sbjct: 369 YEKRDPTSPAPLKTHTIELQGQRTDVRSIDISDDNKLLATAS-NGSLKIWNIKTHKCIRT 427 Query: 131 MQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQP-NFSMVKEIDAAHTESIRDMAFSSND 189 + T K+ +I G +G ++++ + S++ I+ AH +I + +S+ Sbjct: 428 FE--CGYALTCKFLPGGLLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDG 485 Query: 190 SKFVTCSDDNILKIWNFS---------NGKQERVLSGHHW-------DVKSCDWHPEMGL 233 + VT S D +K W+F K VL HH D+ P+ Sbjct: 486 KRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRY 545 Query: 234 IASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRY 293 +A + DN VK++ S S+ K VL +++ S DK+ +++ + + Sbjct: 546 LAISLLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISF-DSKMIITSSADKNIKIWGLDF 604 Query: 294 SMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCI 353 + M +++ P + F D +K++D + YAH + Sbjct: 605 GDCHKSLFAHQDSIMNVKFLPQS-HNFFSCSKDAVVKYWD---GEKFECIQKLYAHQSEV 660 Query: 354 TSLSYNPVGHIFATAAKDRTIRFWTRAR 381 +L+ G +++ D +IR W Sbjct: 661 WALAVATDGGFVVSSSHDHSIRIWEETE 688 Score = 154 bits (389), Expect = 7e-38, Method: Composition-based stats. Identities = 45/243 (18%), Positives = 88/243 (36%), Gaps = 18/243 (7%) Query: 65 IMPPNAYRGRDRVINLPSK-FTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNAS 123 ++ G ++ +L S + I ++ T +G+RLV + W+ Sbjct: 444 LVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFK 503 Query: 124 ---------SFTFETLMQAH-------DSAVTTMKYSHDSDWMISGDADGMIKIWQPNFS 167 F +++ H + ++ S D ++ D +K++ + Sbjct: 504 VENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTVKVFFLDSM 563 Query: 168 MVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDW 227 H + + S + +T S D +KIW G + L H + + + Sbjct: 564 KFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKF 623 Query: 228 HPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCR 287 P+ S SKD +VK WD CI + + V T G +++ S D S R Sbjct: 624 LPQSHNFFSCSKDAVVKYWDGEKFECIQKLYAHQSEVWALAVA-TDGGFVVSSSHDHSIR 682 Query: 288 VFD 290 +++ Sbjct: 683 IWE 685 Score = 144 bits (364), Expect = 6e-35, Method: Composition-based stats. Identities = 40/203 (19%), Positives = 82/203 (40%), Gaps = 16/203 (7%) Query: 66 MPPNAYRGRDRVINLPS----------------KFTHLSSNKVKHVIPAIQWTPEGRRLV 109 + + + + K H ++ ++ I ++ +P+ R L Sbjct: 488 LVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLA 547 Query: 110 VATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMV 169 ++ ++ S F + H V ++ S DS +I+ AD IKIW +F Sbjct: 548 ISLLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDC 607 Query: 170 KEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHP 229 + AH +SI ++ F F +CS D ++K W+ + + L H +V + Sbjct: 608 HKSLFAHQDSIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQKLYAHQSEVWALAVAT 667 Query: 230 EMGLIASASKDNLVKLWDPRSGN 252 + G + S+S D+ +++W+ Sbjct: 668 DGGFVVSSSHDHSIRIWEETEDQ 690 Score = 129 bits (323), Expect = 3e-30, Method: Composition-based stats. Identities = 58/379 (15%), Positives = 118/379 (31%), Gaps = 77/379 (20%) Query: 59 TSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFS 118 S D +PP A R P++ T+L + + L V G Sbjct: 60 VSKLSDGLPPGASDARGAK---PAECTYLEA------------HKDTDLLAVGYADGVIK 104 Query: 119 LWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTE 178 +W+ S T H +A+T +++ +ISG D I +W + +H + Sbjct: 105 VWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGEVGLYKLRSHKD 164 Query: 179 SIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASAS 238 SI + + ++ S D ++K+W+ + H + + L+ + Sbjct: 165 SITGF-WCQGEDWLISTSKDGMIKLWDLKTHQCIETHIAHTGECWGLAVKDD--LLITTG 221 Query: 239 KDNLVKLW--DPRSGNCISSIL-------KFKHTVLKTRF---QPTKGNLLMAISKDKSC 286 D+ VK+W D + + + K LK F K + + DK+ Sbjct: 222 TDSQVKIWKLDIENDKMGGKLTEMGIFEKQSKQRGLKIEFITNSSDKTSFFYIQNADKTI 281 Query: 287 RVFDIRYS------------------------------------MKELMCVRDETDYMTL 310 F IR + +R + Sbjct: 282 ETFRIRKEEEIARGLKKREKRLKEKGLTEEEIAKSIKESYSSFILHPFQTIRSLYKIKSA 341 Query: 311 EWHPINESM--FTLACYDGSLKHFDLLQNLNEPI--------LTIPYAHDKCITSLSYNP 360 W ++ S L +++++ + +P + S+ + Sbjct: 342 SWTTVSSSKLELVLTTSSNTIEYYSIPYEKRDPTSPAPLKTHTIELQGQRTDVRSIDISD 401 Query: 361 VGHIFATAAKDRTIRFWTR 379 + ATA+ + +++ W Sbjct: 402 DNKLLATAS-NGSLKIWNI 419 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 41/206 (19%), Positives = 74/206 (35%), Gaps = 22/206 (10%) Query: 186 SSNDSKFVTCSDDNILKIWNFSNGKQERVLS------------GHHWDVKSCDWHPEMGL 233 S + +D + IW+ G LS + + H + L Sbjct: 36 SGPGQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDL 93 Query: 234 IASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRY 293 +A D ++K+WD S + + K + +F T G L++ SKD + V+D+ Sbjct: 94 LAVGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGT-GTRLISGSKDSNIIVWDLVG 152 Query: 294 SMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCI 353 + L +R D +T W + + + DG +K +DL + AH Sbjct: 153 EVG-LYKLRSHKDSITGFWCQGEDWLIST-SKDGMIKLWDL---KTHQCIETHIAHTGEC 207 Query: 354 TSLSYNPVGHIFATAAKDRTIRFWTR 379 L+ + T D ++ W Sbjct: 208 WGLAVKDD--LLITTGTDSQVKIWKL 231 Score = 96.7 bits (239), Expect = 2e-20, Method: Composition-based stats. Identities = 34/246 (13%), Positives = 76/246 (30%), Gaps = 28/246 (11%) Query: 144 SHDSDWMISGDADGMIKIWQPNFSMVKE------------IDAAHTESIRDMAFSSNDSK 191 S + S D + IW + A + + Sbjct: 36 SGPGQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDL 93 Query: 192 FVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSG 251 D ++K+W+ + +GH + + + S SKD+ + +WD Sbjct: 94 LAVGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGE 153 Query: 252 NCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLE 311 + + K ++ + + L+ + SKD +++D++ + + L Sbjct: 154 VGLYKLRSHKDSITGF-WCQGEDWLI-STSKDGMIKLWDLKTHQCIETHIAHTGECWGLA 211 Query: 312 WHPINESMFTLACYDGSLKHF--DLLQNLNEPILTIPYAHDKCITSLSYNPVGHIF--AT 367 + + + D +K + D+ + LT + I G T Sbjct: 212 ---VKDDLLITTGTDSQVKIWKLDIENDKMGGKLT-----EMGIFEKQSKQRGLKIEFIT 263 Query: 368 AAKDRT 373 + D+T Sbjct: 264 NSSDKT 269 Score = 81.3 bits (199), Expect = 8e-16, Method: Composition-based stats. Identities = 25/160 (15%), Positives = 57/160 (35%), Gaps = 10/160 (6%) Query: 10 QNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPN 69 ++ +K + +D Y++L Y + V+ + S+ ++ + Sbjct: 542 DDRYLAISLLDNTVKVFF-----LDSMKFYLSL-YGHKLP----VLSIDISFDSKMIITS 591 Query: 70 AYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFET 129 + ++ L H S + I +++ P+ + W+ F Sbjct: 592 SADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQ 651 Query: 130 LMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMV 169 + AH S V + + D +++S D I+IW+ V Sbjct: 652 KLYAHQSEVWALAVATDGGFVVSSSHDHSIRIWEETEDQV 691 >5K1B-B nrPDB Length = 677 Score = 168 bits (426), Expect = 4e-42, Method: Composition-based stats. Identities = 56/262 (21%), Positives = 105/262 (40%), Gaps = 21/262 (8%) Query: 135 DSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDA---AHTESIRDMAFSSNDSK 191 + V ++ + + + D +I+IW N A HT+ + D+ N Sbjct: 30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKT 89 Query: 192 FVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSG 251 ++ S D +K+WN G L H VK+ + + L+ASA D + LWD + Sbjct: 90 LISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNT- 148 Query: 252 NCISSILKFKHTVLKTRFQPTK-----------GNLLMAISKDKSCRVFDIRYSMKELMC 300 ++++ +TV + K G ++++ S +K RV+D R K LM Sbjct: 149 --LTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAK-LMK 205 Query: 301 VRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNP 360 ++ TD + + + DG+++ + L Q + + HD+ + +L N Sbjct: 206 LKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQ---QRCIATYRVHDEGVWALQVND 262 Query: 361 VGHIFATAAKDRTIRFWTRARP 382 + +DR I P Sbjct: 263 AFTHVYSGGRDRKIYCTDLRNP 284 Score = 146 bits (367), Expect = 3e-35, Method: Composition-based stats. Identities = 40/273 (14%), Positives = 93/273 (34%), Gaps = 14/273 (5%) Query: 76 RVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFT---FETLMQ 132 R + + ++ + A+Q P RL A +W+ + + M+ Sbjct: 13 RKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASME 72 Query: 133 AHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKF 192 H V + + +IS +D +K+W + H + ++ +A++ + Sbjct: 73 HHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELV 132 Query: 193 VTCSDDNILKIWNFSNGKQER---------VLSGHHWDVKSCDWHPEMGLIASASKDNLV 243 + D + +W+ + LSG+ + S + +I S S + ++ Sbjct: 133 ASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVL 192 Query: 244 KLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRD 303 ++WDPR+ + + V G ++ S D + R++ + Sbjct: 193 RVWDPRTCAKLMKLKGHTDNVKALLLN-RDGTQCLSGSSDGTIRLWSLGQQRCIATYRVH 251 Query: 304 ETDYMTLEWHPINESMFTLACYDGSLKHFDLLQ 336 + L+ + + D + DL Sbjct: 252 DEGVWALQVN-DAFTHVYSGGRDRKIYCTDLRN 283 Score = 132 bits (331), Expect = 4e-31, Method: Composition-based stats. Identities = 41/239 (17%), Positives = 80/239 (33%), Gaps = 17/239 (7%) Query: 177 TESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQ---ERVLSGHHWDVKSCDWHPEMGL 233 + + ++ T D+I++IW+ + KQ + H V Sbjct: 30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKT 89 Query: 234 IASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRY 293 + SAS D VK+W+ G C+S++ K V + L+ + D+ ++D+ Sbjct: 90 LISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYA-KDKELVASAGLDRQIFLWDVNT 148 Query: 294 --------SMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTI 345 + + D + ++ + L+ +D L Sbjct: 149 LTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRT---CAKLMK 205 Query: 346 PYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARP--IDPNAYDDPTYNNKKINGWF 402 H + +L N G + + D TIR W+ + I D ++N F Sbjct: 206 LKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAF 264 Score = 131 bits (330), Expect = 5e-31, Method: Composition-based stats. Identities = 42/313 (13%), Positives = 110/313 (35%), Gaps = 22/313 (7%) Query: 14 QIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRG 73 + ++ + + D PYI + + ++V+ I + Sbjct: 45 LFTAGRDSIIRIWSVNQHKQD---PYIASMEHHTDWVNDIVLCCNGKTLIS----ASSDT 97 Query: 74 RDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFET---- 129 +V N F + K + A+ + + + A + LW+ ++ T T Sbjct: 98 TVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNN 157 Query: 130 -----LMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMA 184 + + ++ ++ + ++SG + ++++W P HT++++ + Sbjct: 158 TVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALL 217 Query: 185 FSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVK 244 + + ++ ++ S D +++W+ + H V + + + S +D + Sbjct: 218 LNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIY 277 Query: 245 LWDPRSGNCISSILKFKHTVLKTRF--QPTKGNLLMAISKDKSCRVFDIRYSMKELMCVR 302 D R+ + I + K VLK + + + + ++K + R Sbjct: 278 CTDLRNPDIRVLICEEKAPVLKMELDRSADPPPAIWVATTKSTVNKW----TLKGIHNFR 333 Query: 303 DETDYMTLEWHPI 315 DY +PI Sbjct: 334 ASGDYDNDCTNPI 346 >6QDV-o nrPDB Length = 513 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 41/260 (15%), Positives = 85/260 (32%), Gaps = 9/260 (3%) Query: 126 TFETLMQAHDSAVTTMKYSH-DSDWMISGDADGMIKIWQPNFSM-VKEIDAAHTESIRDM 183 + H V+ ++ ++S D IK+W+ H++++RD+ Sbjct: 213 KQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDI 272 Query: 184 AFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPE---MGLIASASKD 240 F++ ++F++ + D LK+W+ G+ + ++P+ L + D Sbjct: 273 CFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVP-YCVKFNPDEDKQNLFVAGMSD 331 Query: 241 NLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMC 300 + WD RSG + + V F + ++ S DKS RV++ + Sbjct: 332 KKIVQWDIRSGEIVQEYDRHLGAVNTIVFV-DENRRFVSTSDDKSLRVWEWDIPVDFKYI 390 Query: 301 VRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHD--KCITSLSY 358 M N D + F I H + + Sbjct: 391 AEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDF 450 Query: 359 NPVGHIFATAAKDRTIRFWT 378 +P + + + W Sbjct: 451 SPDMSYVISGDGNGKLNIWD 470 Score = 136 bits (342), Expect = 2e-32, Method: Composition-based stats. Identities = 46/328 (14%), Positives = 116/328 (35%), Gaps = 27/328 (8%) Query: 18 SQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRV 77 S PP K Y+ +++ I+++ G+ + + P + + + + + ++ Sbjct: 201 STMPPEKCYLPKKQ--------IHVWSGHTKGVSAVRLFPLSGHLL---LSCSMDCKIKL 249 Query: 78 INL-PSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDS 136 + + + + I + G + + A Y LW+ + + Sbjct: 250 WEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKV 309 Query: 137 AVTTMKYSHD---SDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFV 193 +K++ D + ++G +D I W + + H ++ + F + +FV Sbjct: 310 P-YCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFV 368 Query: 194 TCSDDNILKIWNFSNGKQERVLSG---HHWDVKSCDWHPEMGLIASASKDNLVKLWDPRS 250 + SDD L++W + + ++ H + P +A S DN + ++ ++ Sbjct: 369 STSDDKSLRVWEWDIPVDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQN 426 Query: 251 GNCI---SSILKFKHTVLK--TRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDET 305 + F P + +++ + ++D + + + Sbjct: 427 RFRLNKKKIFKGHMVAGYACQVDFSP-DMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDK 485 Query: 306 DYMTLEWHPINESMFTLACYDGSLKHFD 333 + WHP S +DG +K +D Sbjct: 486 VCIGAVWHPHETSKVITCGWDGLIKLWD 513 Score = 131 bits (330), Expect = 6e-31, Method: Composition-based stats. Identities = 49/232 (21%), Positives = 84/232 (36%), Gaps = 19/232 (8%) Query: 157 GMIKIWQPNFSMVKEIDAAHTESIRDMA-FSSNDSKFVTCSDDNILKIWN-FSNGKQERV 214 I +W HT+ + + F + ++CS D +K+W + + R Sbjct: 213 KQIHVWS-----------GHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRT 261 Query: 215 LSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTK- 273 GH V+ ++ SA+ D +KLWD +G CIS K +F P + Sbjct: 262 FIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVP-YCVKFNPDED 320 Query: 274 -GNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHF 332 NL +A DK +DIR R T+ + F D SL+ + Sbjct: 321 KQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFV-DENRRFVSTSDDKSLRVW 379 Query: 333 DLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPID 384 + ++ + P H +++ +P G A + D I + Sbjct: 380 EWDIPVDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFR 429 Score = 93.3 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 33/202 (16%), Positives = 69/202 (34%), Gaps = 57/202 (28%) Query: 10 QNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPN 69 +N+ + S L+ + I + + + EP Sbjct: 363 ENRRFVSTSDDKSLRVWEWD----------IPVDFKY-------IAEPSM---------- 395 Query: 70 AYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASS---FT 126 H +PA+ +P G+ L + + ++ A + Sbjct: 396 ------------------------HSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLN 431 Query: 127 FETLMQAHDSA--VTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMA 184 + + + H A + +S D ++ISGD +G + IW + + AH + Sbjct: 432 KKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAV 491 Query: 185 FSSN-DSKFVTCSDDNILKIWN 205 + + SK +TC D ++K+W+ Sbjct: 492 WHPHETSKVITCGWDGLIKLWD 513 Score = 72.9 bits (177), Expect = 3e-13, Method: Composition-based stats. Identities = 28/168 (16%), Positives = 53/168 (31%), Gaps = 13/168 (7%) Query: 254 ISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWH 313 I V R P G+LL++ S D +++++ + L + + Sbjct: 215 IHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICF 274 Query: 314 PINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCI-TSLSYNPV---GHIFATAA 369 + F A YD LK +D T ++ + + +NP ++F Sbjct: 275 NTAGTQFLSAAYDRYLKLWDTETGQCISRFT-----NRKVPYCVKFNPDEDKQNLFVAGM 329 Query: 370 KDRTIRFWTR--ARPIDPNAYDDPTYNNKKI--NGWFFGINNDINAVR 413 D+ I W + N F +D ++R Sbjct: 330 SDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLR 377 >5YZG-W nrPDB Length = 579 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 41/260 (15%), Positives = 85/260 (32%), Gaps = 9/260 (3%) Query: 126 TFETLMQAHDSAVTTMKYSH-DSDWMISGDADGMIKIWQPNFSM-VKEIDAAHTESIRDM 183 + H V+ ++ ++S D IK+W+ H++++RD+ Sbjct: 279 KQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDI 338 Query: 184 AFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPE---MGLIASASKD 240 F++ ++F++ + D LK+W+ G+ + ++P+ L + D Sbjct: 339 CFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVP-YCVKFNPDEDKQNLFVAGMSD 397 Query: 241 NLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMC 300 + WD RSG + + V F + ++ S DKS RV++ + Sbjct: 398 KKIVQWDIRSGEIVQEYDRHLGAVNTIVFV-DENRRFVSTSDDKSLRVWEWDIPVDFKYI 456 Query: 301 VRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHD--KCITSLSY 358 M N D + F I H + + Sbjct: 457 AEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDF 516 Query: 359 NPVGHIFATAAKDRTIRFWT 378 +P + + + W Sbjct: 517 SPDMSYVISGDGNGKLNIWD 536 Score = 136 bits (341), Expect = 3e-32, Method: Composition-based stats. Identities = 46/328 (14%), Positives = 116/328 (35%), Gaps = 27/328 (8%) Query: 18 SQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRV 77 S PP K Y+ +++ I+++ G+ + + P + + + + + ++ Sbjct: 267 STMPPEKCYLPKKQ--------IHVWSGHTKGVSAVRLFPLSGHLL---LSCSMDCKIKL 315 Query: 78 INL-PSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDS 136 + + + + I + G + + A Y LW+ + + Sbjct: 316 WEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKV 375 Query: 137 AVTTMKYSHD---SDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFV 193 +K++ D + ++G +D I W + + H ++ + F + +FV Sbjct: 376 P-YCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFV 434 Query: 194 TCSDDNILKIWNFSNGKQERVLSG---HHWDVKSCDWHPEMGLIASASKDNLVKLWDPRS 250 + SDD L++W + + ++ H + P +A S DN + ++ ++ Sbjct: 435 STSDDKSLRVWEWDIPVDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQN 492 Query: 251 GNCI---SSILKFKHTVLK--TRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDET 305 + F P + +++ + ++D + + + Sbjct: 493 RFRLNKKKIFKGHMVAGYACQVDFSP-DMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDK 551 Query: 306 DYMTLEWHPINESMFTLACYDGSLKHFD 333 + WHP S +DG +K +D Sbjct: 552 VCIGAVWHPHETSKVITCGWDGLIKLWD 579 Score = 131 bits (329), Expect = 7e-31, Method: Composition-based stats. Identities = 49/232 (21%), Positives = 84/232 (36%), Gaps = 19/232 (8%) Query: 157 GMIKIWQPNFSMVKEIDAAHTESIRDMA-FSSNDSKFVTCSDDNILKIWN-FSNGKQERV 214 I +W HT+ + + F + ++CS D +K+W + + R Sbjct: 279 KQIHVWS-----------GHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRT 327 Query: 215 LSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTK- 273 GH V+ ++ SA+ D +KLWD +G CIS K +F P + Sbjct: 328 FIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVP-YCVKFNPDED 386 Query: 274 -GNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHF 332 NL +A DK +DIR R T+ + F D SL+ + Sbjct: 387 KQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFV-DENRRFVSTSDDKSLRVW 445 Query: 333 DLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPID 384 + ++ + P H +++ +P G A + D I + Sbjct: 446 EWDIPVDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFR 495 Score = 92.9 bits (229), Expect = 2e-19, Method: Composition-based stats. Identities = 33/202 (16%), Positives = 69/202 (34%), Gaps = 57/202 (28%) Query: 10 QNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPN 69 +N+ + S L+ + I + + + EP Sbjct: 429 ENRRFVSTSDDKSLRVWEWD----------IPVDFKY-------IAEPSM---------- 461 Query: 70 AYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASS---FT 126 H +PA+ +P G+ L + + ++ A + Sbjct: 462 ------------------------HSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLN 497 Query: 127 FETLMQAHDSA--VTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMA 184 + + + H A + +S D ++ISGD +G + IW + + AH + Sbjct: 498 KKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAV 557 Query: 185 FSSN-DSKFVTCSDDNILKIWN 205 + + SK +TC D ++K+W+ Sbjct: 558 WHPHETSKVITCGWDGLIKLWD 579 Score = 72.5 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 28/168 (16%), Positives = 53/168 (31%), Gaps = 13/168 (7%) Query: 254 ISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWH 313 I V R P G+LL++ S D +++++ + L + + Sbjct: 281 IHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICF 340 Query: 314 PINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCI-TSLSYNPV---GHIFATAA 369 + F A YD LK +D T ++ + + +NP ++F Sbjct: 341 NTAGTQFLSAAYDRYLKLWDTETGQCISRFT-----NRKVPYCVKFNPDEDKQNLFVAGM 395 Query: 370 KDRTIRFWTR--ARPIDPNAYDDPTYNNKKI--NGWFFGINNDINAVR 413 D+ I W + N F +D ++R Sbjct: 396 SDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLR 443 >5Y1U-A nrPDB Length = 456 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 74/364 (20%), Positives = 140/364 (38%), Gaps = 44/364 (12%) Query: 73 GRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYS---GEFSLWNASSFTFET 129 G+D I+ TH S + VI ++Q + + + Y GEF + + S E Sbjct: 89 GKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEI 148 Query: 130 LMQA-HDSAVTTMKYSHDSDWMI---SGDADGMIKIWQPNFSMVKEI----------DAA 175 ++ H+ V +Y + +I + +D + ++ K Sbjct: 149 EIKINHEGEVNRARYMPQNPCIIATKTPSSD--VLVFDYTKHPSKPDPSGECNPDLRLRG 206 Query: 176 HTESIRDMAFSSN-DSKFVTCSDDNILKIWNFSNGKQE-------RVLSGHHWDVKSCDW 227 H + ++++ N ++ SDD+ + +W+ S +E + +GH V+ W Sbjct: 207 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 266 Query: 228 HP-EMGLIASASKDNLVKLWDPRSGNCI---SSILKFKHTVLKTRFQPTKGNLLMAISKD 283 H L S + D + +WD RS N S+ V F P +L S D Sbjct: 267 HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSAD 326 Query: 284 KSCRVFDIRYSMKELMCVRDETD-YMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEP- 341 K+ ++D+R +L D ++W P NE++ + D L +DL + E Sbjct: 327 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQS 386 Query: 342 ----------ILTIPYAHDKCITSLSYNP-VGHIFATAAKDRTIRFWTRARPIDPNAYDD 390 +L I H I+ S+NP + + ++D ++ W A I + + Sbjct: 387 PEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPE 446 Query: 391 PTYN 394 + + Sbjct: 447 GSVD 450 Score = 59.8 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 24/159 (15%), Positives = 50/159 (31%), Gaps = 15/159 (9%) Query: 260 FKHTVLKTRFQPTKGNLLMAISKDKSCRVFD----------IRYSMKELMCVRDETDYMT 309 + V + R+ P ++ + VFD +L + + Sbjct: 154 HEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYG 213 Query: 310 LEWHPINESMFTLACYDGSLKHFDLLQNLNEPIL----TIPYAHDKCITSLSYNP-VGHI 364 L W+P A D ++ +D+ E + TI H + +S++ + Sbjct: 214 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 273 Query: 365 FATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFF 403 F + A D+ + W + ++N F Sbjct: 274 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSF 312 >5WLC-LU nrPDB Length = 489 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 55/325 (16%), Positives = 111/325 (34%), Gaps = 52/325 (16%) Query: 129 TLMQAHDSAVTTMKYSHDS-DWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSS 187 L H V + ++ S + + +G ADG+IK W + AH + + + Sbjct: 61 QLGYGHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQ 120 Query: 188 -----------NDSKFVTCSDDNILKIWNFS-----------------NGKQERVLSGHH 219 + + ++CSDD +K+W+ + R G Sbjct: 121 PRFHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDG-E 179 Query: 220 WDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMA 279 + D H E A+ + LWD +S + + +F + ++L + Sbjct: 180 SAFQGIDSHRENSTFATGGA--KIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILAS 237 Query: 280 ISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLN 339 D S ++D+R + V+ + W+P+ F A D + ++D+ Sbjct: 238 TGSDNSIVLYDLRTNSPTQKIVQTMR-TNAICWNPMEAFNFVTANEDHNAYYYDMRN--L 294 Query: 340 EPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKK-- 397 L + H + + ++P G T + D++IR + N + K Sbjct: 295 SRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKT------NHGHSREIYHTKRM 348 Query: 398 ---------INGWFFGINNDINAVR 413 ++ + +D VR Sbjct: 349 QHVFQVKYSMDSKYIISGSDDGNVR 373 Score = 131 bits (330), Expect = 5e-31, Method: Composition-based stats. Identities = 52/377 (13%), Positives = 130/377 (34%), Gaps = 59/377 (15%) Query: 38 PYI-NLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVI 96 P++ L Y R G+ + +++ + + G + N+ ++ +S ++ Sbjct: 57 PFVGQLGYGHRDGV--YAIAKNYG-SLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLV 113 Query: 97 PAIQWTP-----------EGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSH 145 + T ++ + LW+ + + + + +VT Sbjct: 114 TGLCVTQPRFHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVT------ 167 Query: 146 DSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWN 205 + +G+I+ + + + +S F T + +W+ Sbjct: 168 --------NEEGLIRTFDGESAFQ------------GIDSHRENSTFATGGA--KIHLWD 205 Query: 206 FSNGKQERVLSGHHWDVKSCDWHP-EMGLIASASKDNLVKLWDPRSGNCISSILKFKHTV 264 + K LS ++ S ++ E ++AS DN + L+D R+ + I++ T Sbjct: 206 VNRLKPVSDLSWGADNITSLKFNQNETDILASTGSDNSIVLYDLRTNSPTQKIVQTMRT- 264 Query: 265 LKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDE-TDYMTLEWHPINESMFTLA 323 + P + + ++D + +D+R + L +D + M +++ P + Sbjct: 265 NAICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLNVFKDHVSAVMDVDFSPTGDE-IVTG 323 Query: 324 CYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW------ 377 YD S++ + + I + + + Y+ + + D +R W Sbjct: 324 SYDKSIRIYKTNHGHSREIYHTKR--MQHVFQVKYSMDSKYIISGSDDGNVRLWRSKAWE 381 Query: 378 ----TRARPIDPNAYDD 390 R + YD+ Sbjct: 382 RSNVKTTREKNKLEYDE 398 >3JB9-L nrPDB Length = 340 Score = 165 bits (417), Expect = 5e-41, Method: Composition-based stats. Identities = 45/293 (15%), Positives = 104/293 (35%), Gaps = 17/293 (5%) Query: 92 VKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFET-LMQAHDSAVTTMKYSHDSDWM 150 + ++ P G + LWN ++ A+T +++S DS + Sbjct: 49 HTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQWSRDSRVV 108 Query: 151 ISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFV-TCSDDNILKIWNFSNG 209 +D + W H + + S+ + + SDD +K+W+ + Sbjct: 109 YCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRSK 168 Query: 210 KQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRF 269 + + + + + + + D +K+WD R+ +C + K + Sbjct: 169 DCIKTIEE-KYPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCSHVLKGHKDIITSLAI 227 Query: 270 QPTKGNLLMAISKDKSCRVFDIRY--------SMKELMCVRDETDYMTLEWHPINESMFT 321 G+ L++ S D + R+FD++ + E E + + + W N Sbjct: 228 S-KDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWS-RNSRFVG 285 Query: 322 LACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTI 374 D ++ + + + + H+ + + ++P I + + DRTI Sbjct: 286 AGSSDKNVYVWSATGD----LRYVLPGHEGSVNHVDFHPHQDIILSCSSDRTI 334 Score = 150 bits (379), Expect = 1e-36, Method: Composition-based stats. Identities = 47/275 (17%), Positives = 104/275 (37%), Gaps = 11/275 (4%) Query: 133 AHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKE-IDAAHTESIRDMAFSSNDSK 191 H + V ++ + SG D I +W + + +I D+ +S + Sbjct: 48 GHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQWSRDSRV 107 Query: 192 FVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMG-LIASASKDNLVKLWDPRS 250 S D L W+ +G++ R GH V + D L+ S S D +K+WD RS Sbjct: 108 VYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRS 167 Query: 251 GNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTL 310 +CI +I + K+ + +G + D + +++D+R + ++ D +T Sbjct: 168 KDCIKTIEE-KYPLTAVAIA-QQGTQVFIGGIDGAIKIWDLRNNHCS-HVLKGHKDIITS 224 Query: 311 EWHPINESMFTLACYDGSLKHFDL-----LQNLNEPILTIPYAHDKCITSLSYNPVGHIF 365 + S D +++ FD+ Q + + + + ++++ Sbjct: 225 LAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNSRFV 284 Query: 366 ATAAKDRTIRFWTRARPID-PNAYDDPTYNNKKIN 399 + D+ + W+ + + + N+ + Sbjct: 285 GAGSSDKNVYVWSATGDLRYVLPGHEGSVNHVDFH 319 Score = 148 bits (374), Expect = 4e-36, Method: Composition-based stats. Identities = 47/224 (20%), Positives = 85/224 (37%), Gaps = 6/224 (2%) Query: 157 GMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNF-SNGKQERVL 215 G + + ++ HT + F + S F + D + +WN + K VL Sbjct: 30 GSVLQRTSDLNVPNLQMFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVL 89 Query: 216 SGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGN 275 +G + W + ++ +S D + WD SG I V Sbjct: 90 NGCKGAITDLQWSRDSRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSE 149 Query: 276 LLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLL 335 LL ++S D + +V+D R K+ + +E +T + + DG++K +DL Sbjct: 150 LLTSVSDDCTMKVWDSRS--KDCIKTIEEKYPLTAVAIAQQGTQVFIGGIDGAIKIWDLR 207 Query: 336 QNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTR 379 N + H ITSL+ + G + + D T+R + Sbjct: 208 NNH---CSHVLKGHKDIITSLAISKDGSSLLSNSMDNTVRIFDV 248 Score = 138 bits (348), Expect = 4e-33, Method: Composition-based stats. Identities = 43/245 (17%), Positives = 88/245 (35%), Gaps = 19/245 (7%) Query: 9 YQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPP 68 ++ S L + VS I + + L V S + + Sbjct: 103 RDSRVVYCSSSDTHLMSWDA------VSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSD 156 Query: 69 NAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFE 128 +V + SK + + + K+ + A+ +G ++ + G +W+ + Sbjct: 157 ---DCTMKVWDSRSKDC-IKTIEEKYPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCS 212 Query: 129 TLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQP--------NFSMVKEIDAAHTESI 180 +++ H +T++ S D ++S D ++I+ + + ++ Sbjct: 213 HVLKGHKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNL 272 Query: 181 RDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKD 240 +A+S N S D + +W+ G VL GH V D+HP +I S S D Sbjct: 273 LGVAWSRNSRFVGAGSSDKNVYVWSA-TGDLRYVLPGHEGSVNHVDFHPHQDIILSCSSD 331 Query: 241 NLVKL 245 + L Sbjct: 332 RTIFL 336 Score = 137 bits (346), Expect = 6e-33, Method: Composition-based stats. Identities = 51/315 (16%), Positives = 111/315 (35%), Gaps = 19/315 (6%) Query: 30 RRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFT-HLS 88 +R+ D++ P + + + + +P SY + + N+ + Sbjct: 34 QRTSDLNVPNLQM-FGHTAEVLVARFDPSGSY----FASGGMDRQILLWNVFGDVKNYGV 88 Query: 89 SNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSD 148 N K I +QW+ + R + ++ W+A S + H V + Sbjct: 89 LNGCKGAITDLQWSRDSRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGS 148 Query: 149 WMISG-DADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFS 207 +++ D +K+W + + +A + ++ D +KIW+ Sbjct: 149 ELLTSVSDDCTMKVWDSRSKDCIKTIEE-KYPLTAVAIAQQGTQVFIGGIDGAIKIWDLR 207 Query: 208 NGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCIS--------SILK 259 N VL GH + S + + S S DN V+++D + +I Sbjct: 208 NNHCSHVLKGHKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHG 267 Query: 260 FKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESM 319 +H +L + + A S DK+ V+ ++ + E +++HP + + Sbjct: 268 QEHNLLGVAWS-RNSRFVGAGSSDKNVYVWSATGDLR-YVLPGHEGSVNHVDFHPHQD-I 324 Query: 320 FTLACYDGSLKHFDL 334 D ++ +L Sbjct: 325 ILSCSSDRTIFLGEL 339 >5WYJ-BC nrPDB Length = 817 Score = 164 bits (416), Expect = 5e-41, Method: Composition-based stats. Identities = 47/265 (17%), Positives = 93/265 (35%), Gaps = 23/265 (8%) Query: 1 MDGHNQ------NQYQNQNQIQQSQQPPLKKYVTQRRS--VDVSSPYINLYYNRRH---- 48 +GH S+ + S D+ + YI Sbjct: 384 YEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLP 443 Query: 49 -----GLPNLVVEPETSYTID--IMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQW 101 G P ++ TI I+P ++I + H I A+ Sbjct: 444 NIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKD----INALSV 499 Query: 102 TPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKI 161 +P A+Y +WN + E + H + + + + + D +KI Sbjct: 500 SPNDSIFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQYDKLLATSSGDKTVKI 559 Query: 162 WQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWD 221 W + V + HT +++ +F + + ++C D ++KIW+ S+G+ + L GH+ Sbjct: 560 WSLDTFSVMKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWDCSSGECLKTLDGHNNR 619 Query: 222 VKSCDWHPEMGLIASASKDNLVKLW 246 + + + +I SA D + + W Sbjct: 620 LWALSTMNDGDMIVSADADGVFQFW 644 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 55/344 (15%), Positives = 112/344 (32%), Gaps = 41/344 (11%) Query: 71 YRGRDRVINLPSKFTHLS-SNKVKHVIPAIQ--------WTPEGRRLVVATYSGEFSLWN 121 ++IN+ + + +V I PE +L +AT S + Sbjct: 307 SDQTLQLINVEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIP 366 Query: 122 ASSFTF--------ETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEI- 172 + + + H+ + ++ + D W+ + D +W+ N + K Sbjct: 367 VPDLSGPEASLPLDVEIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDI 426 Query: 173 ---DAAHTESIRDMAFSS-----NDSKFVTCSDDNILKIW---------NFSNGKQ-ERV 214 H+ ++ + + +T S+D +K W + K E Sbjct: 427 YAKYIGHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYT 486 Query: 215 LSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKG 274 H D+ + P + A+AS D K+W+ +G +++ K + F Sbjct: 487 RHAHEKDINALSVSPNDSIFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQYD- 545 Query: 275 NLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDL 334 LL S DK+ +++ + + + DG +K +D Sbjct: 546 KLLATSSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCSFI-NKQKQLISCGADGLIKIWDC 604 Query: 335 LQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWT 378 L H+ + +LS G + +A D +FW Sbjct: 605 SSG---ECLKTLDGHNNRLWALSTMNDGDMIVSADADGVFQFWK 645 Score = 154 bits (390), Expect = 5e-38, Method: Composition-based stats. Identities = 53/349 (15%), Positives = 112/349 (32%), Gaps = 30/349 (8%) Query: 34 DVSSP--YINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFT----HL 87 D+S P + L G +L+ + + + + V + Sbjct: 369 DLSGPEASLPLDVEIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYA 428 Query: 88 SSNKVKHVIPAIQW---TPEG--RRLVVATYSGEFSLWNASSFT----------FETLMQ 132 + A+ +G L+ A+ W T E Sbjct: 429 KYIGHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRH 488 Query: 133 AHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKF 192 AH+ + + S + + D KIW ++ A H + D++F D Sbjct: 489 AHEKDINALSVSPNDSIFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQYDKLL 548 Query: 193 VTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGN 252 T S D +KIW+ + L GH V+ C + + + S D L+K+WD SG Sbjct: 549 ATSSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWDCSSGE 608 Query: 253 CISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFD--------IRYSMKELMCVRDE 304 C+ ++ + + G+++++ D + + +L +++ Sbjct: 609 CLKTLDGHNNRLWALSTM-NDGDMIVSADADGVFQFWKDCTEQEIEEEQEKAKLQVEQEQ 667 Query: 305 TDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCI 353 + + + D ++ F++L+ + + I Sbjct: 668 SLQNYMSKGDWTNAFLLAMTLDHPMRLFNVLKRALGESRSRQDTEEGKI 716 Score = 121 bits (303), Expect = 8e-28, Method: Composition-based stats. Identities = 56/325 (17%), Positives = 121/325 (37%), Gaps = 33/325 (10%) Query: 89 SNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSD 148 S K+ + L V G + + + + H ++++K+ + Sbjct: 98 SMKISSPSYILDADSTSTLLAVGGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLN 157 Query: 149 ----WMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAF--SSNDSK----FVTCSDD 198 + SGD +GM+K+W HT ++R + ++ + ++ D Sbjct: 158 SKIWLLASGDTNGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRD 217 Query: 199 NILKIWNFSNGKQERVLSGHH--WDVKSCDWHPEMG---LIASASKDNLVKLWDPRSGNC 253 +I+ +W+F+ K+ ++L V+SC + + +I +A D + +L D SG+ Sbjct: 218 DIINLWDFNMKKKCKLLKTLPVNQQVESCGFLKDGDGKRIIYTAGGDAIFQLIDSESGSV 277 Query: 254 ISSILKFKHTVLKTRFQP--TKGNLLMAISKDKSCRVFDIRYSMK--------ELMCVRD 303 + K + P + + + +S D++ ++ ++ +K + Sbjct: 278 LKRTNKPIEELFIIGVLPILSNSQMFLVLS-DQTLQLINVEEDLKNDEDTIQVTSSIAGN 336 Query: 304 ETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPI------LTIPYAHDKCITSLS 357 + + + LA SL+ + +L+ P + I H+ + SL Sbjct: 337 HGIIADMRYVGPELNKLALATNSPSLRI-IPVPDLSGPEASLPLDVEIYEGHEDLLNSLD 395 Query: 358 YNPVGHIFATAAKDRTIRFWTRARP 382 G ATA+KD T W Sbjct: 396 ATEDGLWIATASKDNTAIVWRYNEN 420 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 62/430 (14%), Positives = 137/430 (31%), Gaps = 56/430 (13%) Query: 13 NQIQQSQ-QPPLKKYVTQRRSVDVSSPYINLYYNRRHGLP--NLVVEPETSYTIDIMPPN 69 + +K + +R ++ + +++ P+ + Sbjct: 161 WLLASGDTNGMVKVWDLVKRKC------LHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSG 214 Query: 70 AYRGRDRVIN--LPSKFTHLSSNKVKHVIPAIQWTPEG---RRLVVATYSGEFSLWNASS 124 + + + K L + V + + + +G R + A F L ++ S Sbjct: 215 GRDDIINLWDFNMKKKCKLLKTLPVNQQVESCGFLKDGDGKRIIYTAGGDAIFQLIDSES 274 Query: 125 FTFETL--MQAHDSAVTTMKYSHDSDWMISGDADGMIKIW--------QPNFSMVKEIDA 174 + + + + + M +D +++ + V A Sbjct: 275 GSVLKRTNKPIEELFIIGVLPILSNSQMFLVLSDQTLQLINVEEDLKNDEDTIQVTSSIA 334 Query: 175 AHTESIRDMAFS-SNDSKFVTCSDDNILKIW---NFSNGKQ-----ERVLSGHHWDVKSC 225 + I DM + +K ++ L+I + S + + GH + S Sbjct: 335 GNHGIIADMRYVGPELNKLALATNSPSLRIIPVPDLSGPEASLPLDVEIYEGHEDLLNSL 394 Query: 226 DWHPEMGLIASASKDNLVKLWDPRSGNC----ISSILKFKHTVLKT----RFQPTKGNLL 277 D + IA+ASKDN +W +C + + V L Sbjct: 395 DATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPNIVSKGYPEFL 454 Query: 278 MAISKDKSCRVF---------DIRY-SMKELMCVRDETDYMTLEWHPINESMFTLACYDG 327 + S D + + + D++ + E E D L P N+S+F A YD Sbjct: 455 LTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSP-NDSIFATASYDK 513 Query: 328 SLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNA 387 + K ++L + H + + +S+ + AT++ D+T++ W+ Sbjct: 514 TCKIWNLENG---ELEATLANHKRGLWDVSFCQYDKLLATSSGDKTVKIWSL-DTFSVMK 569 Query: 388 YDDPTYNNKK 397 + N + Sbjct: 570 TLEGHTNAVQ 579 Score = 107 bits (267), Expect = 1e-23, Method: Composition-based stats. Identities = 71/465 (15%), Positives = 139/465 (29%), Gaps = 111/465 (23%) Query: 10 QNQNQIQQSQQPPLKKYVTQR----RSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDI 65 Q SQ LK + + RS+ +SSP L + T + Sbjct: 72 DGQYLTYVSQAQLLKIFHLKTGKVVRSMKISSPSYIL---------------DADSTSTL 116 Query: 66 MPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGR----RLVVATYSGEFSLWN 121 + G V+++ + + S I ++++ + L +G +W+ Sbjct: 117 LAVGGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWD 176 Query: 122 ASSFTFETLMQAHDSAVTTMKYS--HDSDW----MISGDADGMIKIWQPNFSMVKEIDAA 175 +Q H SAV + D+D ++SG D +I +W N ++ Sbjct: 177 LVKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLLKT 236 Query: 176 H--TESIRDMAFSSNDS---KFVTCS---------------------------------- 196 + + F + T Sbjct: 237 LPVNQQVESCGFLKDGDGKRIIYTAGGDAIFQLIDSESGSVLKRTNKPIEELFIIGVLPI 296 Query: 197 ----------DDNILKIWNFSNG--------KQERVLSGHHWDVKSCDWH-PEMGLIASA 237 D L++ N + ++G+H + + PE+ +A A Sbjct: 297 LSNSQMFLVLSDQTLQLINVEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALA 356 Query: 238 SKDNLVKLW---DPRSGNC-----ISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVF 289 + +++ D + + + G + SKD + V+ Sbjct: 357 TNSPSLRIIPVPDLSGPEASLPLDVEIYEGHEDLLNSLD-ATEDGLWIATASKDNTAIVW 415 Query: 290 DIRYSMKE---LMCVRDETDYMTLEWHPINESM-----FTLACYDGSLKHFDLLQNLNEP 341 + + + +T P S A D ++K + + + Sbjct: 416 RYNENSCKFDIYAKYIGHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASM 475 Query: 342 ILTIPY-------AHDKCITSLSYNPVGHIFATAAKDRTIRFWTR 379 + I AH+K I +LS +P IFATA+ D+T + W Sbjct: 476 DVQIIKVSEYTRHAHEKDINALSVSPNDSIFATASYDKTCKIWNL 520 Score = 96.0 bits (237), Expect = 3e-20, Method: Composition-based stats. Identities = 40/259 (15%), Positives = 82/259 (31%), Gaps = 17/259 (6%) Query: 131 MQAHDSAVTTMKYSHDSDWMISGDAD--GMIKIWQPNFSMVKEIDAAHTESIRDMAFSSN 188 + A SAV T+ S + + + D +I + + ++ +I + I + + + Sbjct: 15 IYAGSSAVATV--SENGKILATPVLDEINIIDLTPGSRKILHKISNEDEQEITALKLTPD 72 Query: 189 DSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDP 248 S +LKI++ GK R + D L+A D + + D Sbjct: 73 GQYLTYVSQAQLLKIFHLKTGKVVRSMK-ISSPSYILDADSTSTLLAVGGTDGSIIVVDI 131 Query: 249 RSGNCISSILKFKHTVLKTRFQPTKG---NLLMAISKDKSCRVFDIRYSMKELMCVRDET 305 +G S T+ +F LL + + +V+D+ + Sbjct: 132 ENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQEHTS 191 Query: 306 -----DYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNP 360 D + + + D + +D +L ++ + S + Sbjct: 192 AVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLLKTLPV-NQQVESCGFLK 250 Query: 361 VG---HIFATAAKDRTIRF 376 G I TA D + Sbjct: 251 DGDGKRIIYTAGGDAIFQL 269 Score = 91.7 bits (226), Expect = 6e-19, Method: Composition-based stats. Identities = 29/205 (14%), Positives = 72/205 (35%), Gaps = 14/205 (6%) Query: 100 QWTPEGRRLVVATYSGEFSLWNASSFT---FETLMQAHDSAVTTMKYSHDSDWMISGDAD 156 + G+ L E ++ + + + + + +T +K + D ++ Sbjct: 24 TVSENGKILATPVLD-EINIIDLTPGSRKILHKISNEDEQEITALKLTPDGQYLTYVSQA 82 Query: 157 GMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLS 216 ++KI+ V + + S + D + + + NG Sbjct: 83 QLLKIFHLKTGKVVRSMKI-SSPSYILDADSTSTLLAVGGTDGSIIVVDIENGYITHSFK 141 Query: 217 GHHWDVKSCDWHPEMG----LIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRF--- 269 GH + S ++ ++ L+AS + +VK+WD C+ ++ + V Sbjct: 142 GHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEV 201 Query: 270 -QPTKGNL-LMAISKDKSCRVFDIR 292 + +L L++ +D ++D Sbjct: 202 PDNDEPSLNLLSGGRDDIINLWDFN 226 Score = 31.6 bits (70), Expect = 0.79, Method: Composition-based stats. Identities = 13/88 (14%), Positives = 30/88 (34%), Gaps = 1/88 (1%) Query: 290 DIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAH 349 D++ S K + + N + D + DL + + I Sbjct: 2 DLKTSYKGISLNPIYAGSSAVATVSENGKILATPVLD-EINIIDLTPGSRKILHKISNED 60 Query: 350 DKCITSLSYNPVGHIFATAAKDRTIRFW 377 ++ IT+L P G ++ + ++ + Sbjct: 61 EQEITALKLTPDGQYLTYVSQAQLLKIF 88 >3CFV-B nrPDB Length = 414 Score = 161 bits (408), Expect = 5e-40, Method: Composition-based stats. Identities = 60/309 (19%), Positives = 115/309 (37%), Gaps = 37/309 (11%) Query: 112 TYSGEFSLWNASSFTFETLMQA-HDSAVTTMKYSHDS-DWMISGDADGMIKIWQPNFSMV 169 + GEF + + + E ++ H+ V +Y + + + + ++ Sbjct: 102 SDKGEFGGFGSVTGKIECEIKINHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPA 161 Query: 170 KEI----------DAAHTESIRDMAFSSN-DSKFVTCSDDNILKIWNFSNGKQER----- 213 K H + ++++SN ++ SDD+ + +W+ + G +E Sbjct: 162 KPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDA 221 Query: 214 --VLSGHHWDVKSCDWHP-EMGLIASASKDNLVKLWDPRSGNCISS---ILKFKHTVLKT 267 + +GH V+ WH L S + D + +WD RS + V Sbjct: 222 KAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCL 281 Query: 268 RFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETD-YMTLEWHPINESMFTLACYD 326 F P +L S DK+ ++D+R +L D + W P NE++ + D Sbjct: 282 SFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTD 341 Query: 327 GSLKHFDLLQNLNEP-----------ILTIPYAHDKCITSLSYNP-VGHIFATAAKDRTI 374 L +DL + E +L I H I+ S+NP + + ++D + Sbjct: 342 RRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIM 401 Query: 375 RFWTRARPI 383 + W A I Sbjct: 402 QIWQMAENI 410 Score = 118 bits (295), Expect = 6e-27, Method: Composition-based stats. Identities = 35/228 (15%), Positives = 76/228 (33%), Gaps = 29/228 (12%) Query: 97 PAIQWTPE-GRRLVVATYSGEFSLWNASSFTFE-------TLMQAHDSAVTTMKYSHDSD 148 + W L+ A+ LW+ ++ E + H + V + + + Sbjct: 183 YGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHE 242 Query: 149 WMI-SGDADGMIKIWQP---NFSMVKEIDAAHTESIRDMAFSSNDSK-FVTCSDDNILKI 203 + S D + IW S + AHT + ++F+ T S D + + Sbjct: 243 SLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 302 Query: 204 WNFSNGKQ-ERVLSGHHWDVKSCDWHPEMGLI-ASASKDNLVKLWDPRS----------- 250 W+ N K H ++ W P I AS+ D + +WD Sbjct: 303 WDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAE 362 Query: 251 ---GNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSM 295 + + + P + ++ ++S+D +++ + ++ Sbjct: 363 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENI 410 Score = 113 bits (282), Expect = 2e-25, Method: Composition-based stats. Identities = 42/253 (16%), Positives = 91/253 (35%), Gaps = 29/253 (11%) Query: 163 QPNFSMVKEIDAAHTESIRDMAFSSNDSKFV---TCSDDNILKIWNFS----------NG 209 + EI H + + + + T S D + +++++ Sbjct: 112 SVTGKIECEIKINHEGEVNRARYMPQNPHIIATKTPSSD--VLVFDYTKHPAKPDPSGEC 169 Query: 210 KQERVLSGHHWDVKSCDWHPE-MGLIASASKDNLVKLWDPRSG-------NCISSILKFK 261 + L GH + W+ G + SAS D+ V LWD +G + + Sbjct: 170 NPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHS 229 Query: 262 HTVLKTRFQPTKGNLLMAISKDKSCRVFDIRY---SMKELMCVRDETDYMTLEWHPINES 318 V + +L +++ D+ ++D R S + + L ++P +E Sbjct: 230 AVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEF 289 Query: 319 MFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVG-HIFATAAKDRTIRFW 377 + D ++ +DL + L +H I + ++P I A++ DR + W Sbjct: 290 ILATGSADKTVALWDLRN--LKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVW 347 Query: 378 TRARPIDPNAYDD 390 ++ + + +D Sbjct: 348 DLSKIGEEQSAED 360 Score = 102 bits (254), Expect = 3e-22, Method: Composition-based stats. Identities = 40/204 (19%), Positives = 66/204 (32%), Gaps = 26/204 (12%) Query: 218 HHWDVKSCDWHPEMGLIA---SASKDNLVKLWDPR--------SGNCISSIL--KFKHTV 264 H +V + P+ I + S D V ++D SG C + + Sbjct: 125 HEGEVNRARYMPQNPHIIATKTPSSD--VLVFDYTKHPAKPDPSGECNPDLRLRGHQKEG 182 Query: 265 LKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVR-------DETDYMTLEWHPINE 317 + L++ S D + ++DI KE V + WH ++E Sbjct: 183 YGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHE 242 Query: 318 SMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGH-IFATAAKDRTIRF 376 S+F D L +D N + AH + LS+NP I AT + D+T+ Sbjct: 243 SLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 302 Query: 377 WTRAR---PIDPNAYDDPTYNNKK 397 W + Sbjct: 303 WDLRNLKLKLHTFESHKDEIFQVH 326 Score = 57.4 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 21/159 (13%), Positives = 49/159 (30%), Gaps = 15/159 (9%) Query: 260 FKHTVLKTRFQPTKGNLLMAISKDKSCRVFD----------IRYSMKELMCVRDETDYMT 309 + V + R+ P +++ + VFD +L + + Sbjct: 125 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYG 184 Query: 310 LEWHPINESMFTLACYDGSLKHFDLLQNLNEPIL----TIPYAHDKCITSLSYNP-VGHI 364 L W+ A D ++ +D+ E + I H + ++++ + Sbjct: 185 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 244 Query: 365 FATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFF 403 F + A D+ + W + ++N F Sbjct: 245 FGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSF 283 >4J0W-A nrPDB Length = 343 Score = 161 bits (407), Expect = 6e-40, Method: Composition-based stats. Identities = 46/295 (15%), Positives = 95/295 (32%), Gaps = 24/295 (8%) Query: 95 VIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQ-----------AHDSAVTTMKY 143 I + TP+ + A W+ S ++ H S V M Sbjct: 16 SITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMAI 75 Query: 144 SHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKI 203 S D ++ SGD +I IW+ H +++ +AF + + S D +K+ Sbjct: 76 SSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKV 135 Query: 204 WNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHT 263 WN + L GH V + D + + +D V++W + + + + Sbjct: 136 WNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL-VFYGHQGS 194 Query: 264 VLKTRFQPTKGNLLMAISKDKSCRVFDIR-----YSMKELMCVRDETDYMTLEWHP---- 314 + +++ + D S ++ + +E +R E W Sbjct: 195 IDCIHL--INEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAA 252 Query: 315 -INESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATA 368 +N + + ++ + + + L I SL ++ G Sbjct: 253 LLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPLVGFINSLKFSSSGDFLVAG 307 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 50/302 (16%), Positives = 97/302 (32%), Gaps = 27/302 (8%) Query: 128 ETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEID-----------AAH 176 +++ H ++T + + D + S D I W + H Sbjct: 7 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 66 Query: 177 TESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIAS 236 + + MA SS+ + ++ IW + + +GH V + + S Sbjct: 67 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYS 126 Query: 237 ASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMK 296 S D VK+W+ + + ++ + V + + A +D + RV+ I + Sbjct: 127 TSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCV-TAGGRDGTVRVWKIPEESQ 185 Query: 297 ELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAH------- 349 + + + H INE DGS+ + L + P+ AH Sbjct: 186 LVF-YGHQGSIDCI--HLINEEHMVSGADDGSVALWGLSK--KRPLALQREAHGLRGEPG 240 Query: 350 ---DKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFFGIN 406 I+S++ + AT + +R W IN F + Sbjct: 241 LEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPLVGFINSLKFSSS 300 Query: 407 ND 408 D Sbjct: 301 GD 302 Score = 117 bits (294), Expect = 7e-27, Method: Composition-based stats. Identities = 43/309 (13%), Positives = 95/309 (30%), Gaps = 26/309 (8%) Query: 46 RRHGLPNLVVEPETSYTID-----IMPPNAYRGRDRVINLP--SKFTHLSSNKVKHVIPA 98 + + LVV P+ S + + ++ +P K + Sbjct: 13 HQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLC 72 Query: 99 IQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGM 158 + + +G+ L S +W A S H AV+ + + + + S D Sbjct: 73 MAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRS 132 Query: 159 IKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGH 218 +K+W + E H +++ + S + D +++W Q V GH Sbjct: 133 VKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL-VFYGH 191 Query: 219 HWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKH------------TVLK 266 + E + S + D V LW ++ + + H + Sbjct: 192 QGSIDCIHLINEEHM-VSGADDGSVALWGLSKKRPLA-LQREAHGLRGEPGLEQPFWISS 249 Query: 267 TRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDY---MTLEWHPINESMFTLA 323 +L+ S R++ ++L + D +L++ + + Sbjct: 250 VA-ALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPLVGFINSLKFSSSGDFLVAGV 308 Query: 324 CYDGSLKHF 332 + L + Sbjct: 309 GQEHRLGRW 317 Score = 92.1 bits (227), Expect = 4e-19, Method: Composition-based stats. Identities = 41/241 (17%), Positives = 75/241 (31%), Gaps = 23/241 (9%) Query: 208 NGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSI---------- 257 RVL GH + P+ I SA+KD + W SG + I Sbjct: 3 EAADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGK 62 Query: 258 -LKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPIN 316 VL + G L + + K +++ + L + Sbjct: 63 PPGHSSHVLCMAIS-SDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGT 121 Query: 317 ESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRF 376 +++ +D S+K +++ +N + + H + +L +D T+R Sbjct: 122 HQLYST-SHDRSVKVWNVAEN---SYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRV 177 Query: 377 WTRARPID-PNAYDDPTYNNKK-INGWFFGINNDINAVREKSEFGAAPPPPATL--EPHA 432 W + + IN D +V + +G + P L E H Sbjct: 178 WKIPEESQLVFYGHQGSIDCIHLINEEHMVSGADDGSV---ALWGLSKKRPLALQREAHG 234 Query: 433 L 433 L Sbjct: 235 L 235 Score = 34.7 bits (78), Expect = 0.091, Method: Composition-based stats. Identities = 11/43 (25%), Positives = 16/43 (37%) Query: 337 NLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTR 379 + + H IT L P +AAKD +I W+ Sbjct: 1 GPEAADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSV 43 >5OQL-J nrPDB Length = 912 Score = 161 bits (407), Expect = 7e-40, Method: Composition-based stats. Identities = 68/440 (15%), Positives = 141/440 (32%), Gaps = 74/440 (16%) Query: 10 QNQNQIQQSQQPPLKKYVTQR-----RSVDVSSPYINLYYNRRHGLPNLVVEPETSYTID 64 + + L+ + T + D S + +L++ + +T+ Sbjct: 285 EGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILCAQADFTLV 344 Query: 65 IM-PPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSL---- 119 + P+ + + S ++ P+ + +AT S + + Sbjct: 345 LYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVSVK 404 Query: 120 ----WNASSFTFE---------TLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQP-- 164 ++ + L++ H+ V ++ W+ SG D ++W+ Sbjct: 405 DAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDP 464 Query: 165 --NFSMVKEIDAAHTESIRDMA----FSSNDSK------------FVTCSDDNILKIWNF 206 N + H ES+ +A +S+ ++ S D ++ + Sbjct: 465 ANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDI 524 Query: 207 -----SNGKQERVLS--GHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILK 259 GK L H D+ + D P L ASAS+D VK+WD + Sbjct: 525 PRQLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGILRG 584 Query: 260 FKHTVLKTRFQPTKGNLL-------------MAISKDKSCRVFDIRYSMKELMCVRDETD 306 K V RF P ++ + S DK+ +++++ + Sbjct: 585 HKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHN 644 Query: 307 YMTLEWH--------PINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSY 358 + + W + F A D +K +D E H+ + +L+ Sbjct: 645 VLKVVWLHISRDDSITKTKVQFASAGADTLVKVWDANTGETEC---TLDNHEDRLWTLAV 701 Query: 359 NPVGHIFATAAKDRTIRFWT 378 + +I A+A D + FW Sbjct: 702 HSKTNILASAGSDSKVTFWR 721 Score = 141 bits (356), Expect = 5e-34, Method: Composition-based stats. Identities = 78/505 (15%), Positives = 171/505 (33%), Gaps = 99/505 (19%) Query: 2 DGHNQNQYQNQNQIQQ-------SQQPPLKKY-VTQRRSVDVSSPYINLYYNRRHGLPNL 53 G + Q + ++I +Q ++ + + +R + V + + + Sbjct: 179 KGSRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCI 238 Query: 54 VVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKH-VIPAIQWTPEGRRLVVAT 112 PE + + + L + ++H ++ ++ + EG+ + A Sbjct: 239 AYSPEQHALLS----GSRDKTMTLW-LWRDGIWQGTPMLRHELLESVGFLNEGKWMYSAG 293 Query: 113 YSGEFSLWNASSFTFETLMQAHDS---AVTTMKYSHDSDWMISGDADGMIKIWQPNF--- 166 SG +W+ ++ T Q S A+ + + ++ AD + +++ Sbjct: 294 TSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILCAQADFTLVLYRVPSPAD 353 Query: 167 ----------SMVKEIDAAHTESIRDMAFS-SNDSKFVTCSDDNILKIWNFSNGKQER-- 213 + I H + I D+ + + S ++ ++I + + + Sbjct: 354 VVSSSEGILLEPFRRISGTH-DEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSED 412 Query: 214 ---------------VLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDP----RSGNCI 254 +L GH V S D IAS SKDN +LW S C Sbjct: 413 NAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYTCY 472 Query: 255 SSILKFKHTVLKTRF-------------QPTK--GNLLMAISKDKSCRVFDIRYSMK--- 296 + +V P L++ S+D+ + DI ++ Sbjct: 473 AVFTGHLESVGAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGG 532 Query: 297 ----ELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKC 352 L + + D L+ P N +F A D ++K +D+ + + I H + Sbjct: 533 KLTSSLRRLAHDKDINALDISP-NGKLFASASQDKTVKIWDVEK---LEVQGILRGHKRG 588 Query: 353 ITSLSYNPVGH--------------IFATAAKDRTIRFWTRARP--IDPNAYDDPTYNNK 396 + ++ + P+ + T + D+TI+ W + I ++N Sbjct: 589 VWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGH--SHNVL 646 Query: 397 KINGWFFGINNDINAVREKSEFGAA 421 K+ + I+ D + + K +F +A Sbjct: 647 KV--VWLHISRDDSITKTKVQFASA 669 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 52/401 (12%), Positives = 118/401 (29%), Gaps = 71/401 (17%) Query: 49 GLPNLVVEPETSYTIDIMPPNAYR----GRDRVINLPSKFTHLSSNKVKHVIPAIQWTPE 104 + L + P S+ I R + ++ + + Sbjct: 63 PISTLTITPSGSHLIVCSRSLTMRIYSLAISPDYDSVEPTLVRTTKPHATPVVVLAVDRT 122 Query: 105 GRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKY--------------------- 143 L G +W+ + V+ + + Sbjct: 123 STLLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHFFEIAVTAESQSSNKKPKKGSR 182 Query: 144 ---SHDSDWMIS------GDADGMIKIWQPNFSM-------VKEIDAAHTESIRDMAFSS 187 + D+D + S G DG I+I+ K AH +++ +A+S Sbjct: 183 KGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSP 242 Query: 188 NDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWD 247 ++ S D + +W + +G + H ++S + E + SA ++++WD Sbjct: 243 EQHALLSGSRDKTMTLWLWRDGIWQGTPMLRHELLESVGFLNEGKWMYSAGTSGVLRIWD 302 Query: 248 PRSG---NCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRD- 303 + +L P + +L++ D + ++ + + Sbjct: 303 TTTHHEITKKQDAKSEGEAILSAVSLP-ERSLILCAQADFTLVLYRVPSPADVVSSSEGI 361 Query: 304 -----------ETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLN------------- 339 + + L + ++SM +A ++ + Sbjct: 362 LLEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSY 421 Query: 340 -EPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTR 379 + + H+ + SL + GH A+ +KD T R W Sbjct: 422 FGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRV 462 Score = 114 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 46/356 (12%), Positives = 107/356 (30%), Gaps = 48/356 (13%) Query: 81 PSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTT 140 + F + + + ++ R L L ++ +Q ++T Sbjct: 8 KTTFEVANVIQPIYTGGSVALENGARILASTLGENAI-LTELNTGKRLAEIQGDGEPIST 66 Query: 141 MKYSHDSDWMISGDADGMIKIWQPNFS--------MVKEIDAAHTESIRDMAFSSNDSKF 192 + + +I ++I+ S + H + +A + Sbjct: 67 LTITPSGSHLIVCSRSLTMRIYSLAISPDYDSVEPTLVRTTKPHATPVVVLAVDRTSTLL 126 Query: 193 VTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDW------------------------H 228 T + D +KIW+ G +SG V + + + Sbjct: 127 ATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQN 186 Query: 229 PEMGLIAS------ASKDNLVKLWDPRSGNCI-------SSILKFKHTVLKTRFQPTKGN 275 + IAS ++D ++++D + V + P + Sbjct: 187 DDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHA 246 Query: 276 LLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLL 335 LL + S+DK+ ++ R + + + ++ + + M+ A G L+ +D Sbjct: 247 LL-SGSRDKTMTLWLWRDGIWQGTPMLRHELLESVGFLNEGKWMY-SAGTSGVLRIWDTT 304 Query: 336 QNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYDDP 391 + + + I S P + A D T+ + P D + + Sbjct: 305 THHEITKKQDAKSEGEAILSAVSLPERSLILCAQADFTLVLYRVPSPADVVSSSEG 360 >3C9C-A nrPDB Length = 432 Score = 159 bits (403), Expect = 2e-39, Method: Composition-based stats. Identities = 67/362 (18%), Positives = 135/362 (37%), Gaps = 42/362 (11%) Query: 72 RGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYS---GEFSLWNASSFTFE 128 G+D ++ TH S + +I ++Q E + + Y GEF + + E Sbjct: 63 DGKDYSVHRLILGTHTSDEQNHLLIASVQLPSEDAQFDGSHYDNEKGEFGGFGSVCGKIE 122 Query: 129 TLMQA-HDSAVTTMKYSHDS-DWMISGDADGMIKIWQPNFSMVKE----------IDAAH 176 ++ H+ V +Y + + + + ++ K H Sbjct: 123 IEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGH 182 Query: 177 TESIRDMAFSSN-DSKFVTCSDDNILKIWNFSNGKQE-------RVLSGHHWDVKSCDWH 228 + ++++ N + ++ SDD+ + +W+ + +E + +GH V+ WH Sbjct: 183 QKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWH 242 Query: 229 P-EMGLIASASKDNLVKLWDPR---SGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDK 284 L S + D + +WD R + ++ V F P +L S DK Sbjct: 243 LLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADK 302 Query: 285 SCRVFDIRYSMKELMCVRDETD-YMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEP-- 341 + ++D+R +L D ++W P NE++ + D L +DL + E Sbjct: 303 TVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQST 362 Query: 342 ---------ILTIPYAHDKCITSLSYNP-VGHIFATAAKDRTIRFWTRARPIDPNAYDDP 391 +L I H I+ S+NP I + ++D ++ W A + ++P Sbjct: 363 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENV--YNDEEP 420 Query: 392 TY 393 Sbjct: 421 EI 422 Score = 59.4 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 22/159 (13%), Positives = 49/159 (30%), Gaps = 15/159 (9%) Query: 260 FKHTVLKTRFQPTKGNLLMAISKDKSCRVFD----------IRYSMKELMCVRDETDYMT 309 + V + R+ P ++ + VFD +L + + Sbjct: 129 HEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYG 188 Query: 310 LEWHPINESMFTLACYDGSLKHFDLLQNLNEPIL----TIPYAHDKCITSLSYNP-VGHI 364 L W+P A D ++ +D+ E + I H + ++++ + Sbjct: 189 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 248 Query: 365 FATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFF 403 F + A D+ + W + ++N F Sbjct: 249 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSF 287 >4YCZ-A nrPDB Length = 876 Score = 159 bits (403), Expect = 2e-39, Method: Composition-based stats. Identities = 55/243 (22%), Positives = 88/243 (36%), Gaps = 30/243 (12%) Query: 174 AAHTESIRDMAFSSNDSKFVTCSDDNILKIWNF--SNGKQERVLSGHHWDVKSCDW-HPE 230 + H + I D + TCS D +KI+ + L GH V W HP+ Sbjct: 15 SGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPK 74 Query: 231 -MGLIASASKDNLVKLWDPRSG--NCISSILKFKHTVLKTRFQPTK-GNLLMAISKDKSC 286 ++ASA D V +W +G I K +V + P + G LL S D + Sbjct: 75 YGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNV 134 Query: 287 RVFDIRYSMKELMCVRDET-DYMTLEWHP----------------INESMFTLACYDGSL 329 V + R + E ++ W P F D +L Sbjct: 135 SVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNAL 194 Query: 330 KHF--DLLQNLNEPILTIPYAHDKCITSLSYNPV---GHIFATAAKDRTIRFWTRARPID 384 K + D N + H + ++++P A+A++DRT+R WT + P + Sbjct: 195 KIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWT-SDPAN 253 Query: 385 PNA 387 P Sbjct: 254 PLQ 256 Score = 146 bits (367), Expect = 3e-35, Method: Composition-based stats. Identities = 53/280 (18%), Positives = 104/280 (37%), Gaps = 38/280 (13%) Query: 47 RHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSS--NKVKHVIPAIQW-TP 103 G +++ + Y + + ++ + + L+ + + W P Sbjct: 14 NSGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHP 73 Query: 104 E-GRRLVVATYSGEFSLWNASSFTFETLMQ--AHDSAVTTMKYSHD--SDWMISGDADGM 158 + G L A Y G+ +W + ++ + H ++V + +S + +DG Sbjct: 74 KYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGN 133 Query: 159 IKIWQ-PNFSMVKEIDAAHTESIRDMAF-----------------SSNDSKFVTCSDDNI 200 + + + + S I AH + +++ S+ + +FVT DN Sbjct: 134 VSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNA 193 Query: 201 LKIWNFSNGKQE-----RVLSGHHWDVKSCDWHP---EMGLIASASKDNLVKLWDPRSGN 252 LKIW + L+GH V+ W P + IASAS+D V++W N Sbjct: 194 LKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPAN 253 Query: 253 CIS---SILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVF 289 + +L F V + + GN+L A D ++ Sbjct: 254 PLQWNCKVLNFDAAVWRVSWS-LSGNVLAASGGDNKVTLW 292 Score = 143 bits (360), Expect = 2e-34, Method: Composition-based stats. Identities = 43/299 (14%), Positives = 96/299 (32%), Gaps = 37/299 (12%) Query: 85 THLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNA--SSFTFETLMQAHDSAVTTMK 142 ++++ +I GRRL + ++ + ++ HD AV + Sbjct: 10 QVIANSGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVS 69 Query: 143 YSHD--SDWMISGDADGMIKIW-QPNFSMVKEID-AAHTESIRDMAFSSN--DSKFVTCS 196 ++H + + S DG + IW + N + + D A H S+ +++S + S Sbjct: 70 WAHPKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACAS 129 Query: 197 DDNILKIWNFSNGK-QERVLSGHHWDVKSCDWHP-----------------EMGLIASAS 238 D + + F + + + H V S W P + Sbjct: 130 SDGNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGG 189 Query: 239 KDNLVKLW--DPRSGNC---ISSILKFKHTVLKTRFQPT--KGNLLMAISKDKSCRVFDI 291 DN +K+W DP + + V + PT + + + + S+D++ R++ Sbjct: 190 SDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTS 249 Query: 292 RYSMK---ELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPY 347 + + + + W + D + + + Sbjct: 250 DPANPLQWNCKVLNFDAAVWRVSWSLSGNVLAASGG-DNKVTLWKENLKGEWECVKTIE 307 Score = 55.1 bits (131), Expect = 6e-08, Method: Composition-based stats. Identities = 13/91 (14%), Positives = 32/91 (35%), Gaps = 6/91 (6%) Query: 83 KFTHLSSNKVKHVIPAIQWTP---EGRRLVVATYSGEFSLWN---ASSFTFETLMQAHDS 136 K + + W+P + + A+ +W A+ + + D+ Sbjct: 207 KLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPANPLQWNCKVLNFDA 266 Query: 137 AVTTMKYSHDSDWMISGDADGMIKIWQPNFS 167 AV + +S + + + D + +W+ N Sbjct: 267 AVWRVSWSLSGNVLAASGGDNKVTLWKENLK 297 >5FA5-B nrPDB Length = 367 Score = 159 bits (403), Expect = 2e-39, Method: Composition-based stats. Identities = 66/261 (25%), Positives = 111/261 (42%), Gaps = 12/261 (4%) Query: 81 PSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNA-SSFTFETLM---QAHDS 136 P++ + + + + + W E R ++VA+ SG LW + T HD Sbjct: 93 PNEGFCSAGVQTEAGVADLTWVGE-RGILVASDSGAVELWELDENETLIVSKFCKYEHDD 151 Query: 137 AVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSN-DSKFVTC 195 V+T+ +SG D IK+W +V AH + +A S + DS F++C Sbjct: 152 IVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSC 211 Query: 196 SDDNILKIWNFSNGKQERVL--SGHHWDVKSCDWHPEMG-LIASASKDNLVKLWDPRSGN 252 S+DN + +W+ K + S + S WHP+ + ++ V L D +S + Sbjct: 212 SEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTS 271 Query: 253 CISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMT-LE 311 C+ S V F P L ++S+D S V D S+ EL + D++ Sbjct: 272 CVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD--SSLSELFRSQAHRDFVRDAT 329 Query: 312 WHPINESMFTLACYDGSLKHF 332 W P+N S+ T +D + H Sbjct: 330 WSPLNHSLLTTVGWDHQVVHH 350 Score = 114 bits (286), Expect = 7e-26, Method: Composition-based stats. Identities = 53/334 (15%), Positives = 117/334 (35%), Gaps = 27/334 (8%) Query: 59 TSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVAT------ 112 PP R NLP + ++ + A ++ +G L+ A+ Sbjct: 23 QGSLRKETPPPLVPPAAREWNLP----PNAPACMERQLEAARYRSDGALLLGASSLSGRC 78 Query: 113 YSGEFSLWN----ASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFS- 167 ++G L+ A + F + ++ V + + + ++ G +++W+ + + Sbjct: 79 WAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILV-ASDSGAVELWELDENE 137 Query: 168 ---MVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKS 224 + K H + + ++ S+ ++ V+ S D +K+W+ + H V Sbjct: 138 TLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTC 197 Query: 225 CDWHPEM-GLIASASKDNLVKLWDPRSGNCISSI--LKFKHTVLKTRFQPTKGNLLMAIS 281 P + S S+DN + LWD R S I + + P + + + Sbjct: 198 VAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGD 257 Query: 282 KDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEP 341 ++ + + D + + L L + P + D SL D + Sbjct: 258 ENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD----SSLS 313 Query: 342 ILTIPYAHDKCITSLSYNPVG-HIFATAAKDRTI 374 L AH + +++P+ + T D + Sbjct: 314 ELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 347 Score = 82.9 bits (203), Expect = 3e-16, Method: Composition-based stats. Identities = 31/239 (12%), Positives = 77/239 (32%), Gaps = 15/239 (6%) Query: 12 QNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAY 71 + + S ++ + + S + Y ++V + + Sbjct: 117 RGILVASDSGAVELWELDENETLIVSKFCK--YEHD----DIVSTVSVLSSGTQAVSGSK 170 Query: 72 RGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGR-RLVVATYSGEFSLWNASSFTFETL 130 +V +L + S + + +P + + LW+ + Sbjct: 171 DICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQ 230 Query: 131 MQAHDSA---VTTMKYSH-DSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFS 186 + + T++ + S+ + GD +G + + + A H++ + + FS Sbjct: 231 I-GCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFS 289 Query: 187 SND-SKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHP-EMGLIASASKDNLV 243 + + S+D L + + S + R H V+ W P L+ + D+ V Sbjct: 290 PHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFVRDATWSPLNHSLLTTVGWDHQV 347 Score = 62.1 bits (149), Expect = 5e-10, Method: Composition-based stats. Identities = 24/139 (17%), Positives = 55/139 (39%), Gaps = 10/139 (7%) Query: 248 PRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYS---MKELMCVRDE 304 P G C + + V + +G L+ + S + ++++ + + C + Sbjct: 93 PNEGFCSAGVQTEAG-VADLTWVGERGILVASDS--GAVELWELDENETLIVSKFCKYEH 149 Query: 305 TDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNP-VGH 363 D ++ + + D +K +DL Q + +L+ AH +T ++ +P Sbjct: 150 DDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQ---QVVLSSYRAHAAQVTCVAASPHKDS 206 Query: 364 IFATAAKDRTIRFWTRARP 382 +F + ++D I W P Sbjct: 207 VFLSCSEDNRILLWDTRCP 225 Score = 45.5 bits (106), Expect = 5e-05, Method: Composition-based stats. Identities = 27/124 (21%), Positives = 50/124 (40%), Gaps = 15/124 (12%) Query: 272 TKGNLLMAISKDKSCRVF--------DIRYSMKELMC---VRDETDYMTLEWHPINESMF 320 + G LL+ S S R + D + E C V+ E L W + E Sbjct: 63 SDGALLLGASS-LSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTW--VGERGI 119 Query: 321 TLACYDGSLKHFDLLQNLNEPILTIPY-AHDKCITSLSYNPVGHIFATAAKDRTIRFWTR 379 +A G+++ ++L +N + HD ++++S G + +KD I+ W Sbjct: 120 LVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDL 179 Query: 380 ARPI 383 A+ + Sbjct: 180 AQQV 183 >5XYI-g nrPDB Length = 335 Score = 154 bits (390), Expect = 5e-38, Method: Composition-based stats. Identities = 48/312 (15%), Positives = 104/312 (33%), Gaps = 25/312 (8%) Query: 87 LSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFE-----TLMQAHDSAVTTM 141 + I +I+ E LV A+ +W + + T + H+ V+ + Sbjct: 27 ATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDV 86 Query: 142 KYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNIL 201 S D+ +++ D +++W + K++ H + + + FS + + ++ DN + Sbjct: 87 SLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIISVGRDNQV 146 Query: 202 KIWNFSNGKQERVLSGHHWDVKSCDWHPEMG-----LIASASKDNLVKLWDPR-SGNCIS 255 KIWN + + V S P +IA D V +W I Sbjct: 147 KIWNILGENKAEL--QCSSWVTSVACAPMADETSPLVIAVGCWDGKVYIWSIEKEAKLIK 204 Query: 256 SILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPI 315 F P ++ S D+ ++ + + + + + + P Sbjct: 205 EFKAHDGRCTSVDFTPDGKWVITGGS-DRKVVMW-LTENGAKTISFTAPSPVHAVAACPT 262 Query: 316 NESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKC--------ITSLSYNPVGHIFAT 367 A + +D+ ++ + H+ T L++ G + + Sbjct: 263 QAW--ICAATYEGIAVWDIGAKQQIDLVQPNFKHEGKRNAGRTPDCTCLAWAADGSVLYS 320 Query: 368 AAKDRTIRFWTR 379 D +IR W Sbjct: 321 GYNDGSIRAWEV 332 Score = 152 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 50/316 (15%), Positives = 107/316 (33%), Gaps = 31/316 (9%) Query: 122 ASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVK-----EIDAAH 176 ++ F H++A+ +++ ++ ++++S D +W+ N + + H Sbjct: 20 SAHFAPRATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGH 79 Query: 177 TESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIAS 236 + D++ S + S +T S D+ L++W+ S +++ GH DV + P I S Sbjct: 80 NHFVSDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIIS 139 Query: 237 ASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQP----TKGNLLMAISKDKSCRVFDIR 292 +DN VK+W+ N + L+ V P T ++ D ++ I Sbjct: 140 VGRDNQVKIWNILGEN--KAELQCSSWVTSVACAPMADETSPLVIAVGCWDGKVYIWSIE 197 Query: 293 YSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKC 352 K + + T + D + + T P Sbjct: 198 KEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGAKTISFTAP----SP 253 Query: 353 ITSLSYNPVGHIFATAAKDRTIRFWTRARP-----IDPNAYDDPTYNNKKI--------- 398 + +++ P A + I W + PN + N + Sbjct: 254 VHAVAACPTQAWICAATYEG-IAVWDIGAKQQIDLVQPNFKHEGKRNAGRTPDCTCLAWA 312 Query: 399 -NGWFFGINNDINAVR 413 +G + ++R Sbjct: 313 ADGSVLYSGYNDGSIR 328 Score = 132 bits (331), Expect = 4e-31, Method: Composition-based stats. Identities = 44/301 (14%), Positives = 108/301 (35%), Gaps = 27/301 (8%) Query: 10 QNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPN 69 ++ + S+ + R ++P+ H + ++ + + S+ + + Sbjct: 44 EHNYLVSASRDKSALVWKLNRTQEQWATPFT-RLIGHNHFVSDVSLSRDASHLLT----S 98 Query: 70 AYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFET 129 ++ R+ +L ++ T K + + ++P RR++ + +WN + Sbjct: 99 SWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIISVGRDNQVKIWNIL-GENKA 157 Query: 130 LMQAHDSAVTTMKYSHDSD-----WMISGDADGMIKIWQPNFSMVK-EIDAAHTESIRDM 183 +Q S VT++ + +D + G DG + IW + AH + Sbjct: 158 ELQ-CSSWVTSVACAPMADETSPLVIAVGCWDGKVYIWSIEKEAKLIKEFKAHDGRCTSV 216 Query: 184 AFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLV 243 F+ + +T D + +W NG + + V + P I +A+ + + Sbjct: 217 DFTPDGKWVITGGSDRKVVMWLTENGAKTISFTA-PSPVHAVAACPTQAWICAATYEG-I 274 Query: 244 KLWDPRSGN---CISSILKFKH--------TVLKTRFQPTKGNLLMAISKDKSCRVFDIR 292 +WD + + K + + G++L + D S R ++++ Sbjct: 275 AVWDIGAKQQIDLVQPNFKHEGKRNAGRTPDCTCLAWAA-DGSVLYSGYNDGSIRAWEVK 333 Query: 293 Y 293 Sbjct: 334 S 334 >5N4A-A nrPDB Length = 771 Score = 152 bits (384), Expect = 3e-37, Method: Composition-based stats. Identities = 47/250 (18%), Positives = 92/250 (36%), Gaps = 16/250 (6%) Query: 72 RGRDRVINLPSKFTHLSSNKVKHVIPAIQWTP---------EGRRLVVATYSGEFSLWNA 122 N+ + S + + W P VA G + + Sbjct: 34 DQTIHKWNMLGEPEQKVST-LDAYFTDMHWYPVSSKKTQAGGTDVFAVACTDGSVKILS- 91 Query: 123 SSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRD 182 + E ++ H A ++++S+D + + DG +KIW N M++ A + Sbjct: 92 RTGRVEKSIEGHKGACISLRWSYDGTALATAGEDGSVKIWSRN-GMLRSTLAQADSPVYS 150 Query: 183 MAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNL 242 + ++ + + C+ N++ I + S+ ++ H V DW P LI + +D Sbjct: 151 IVWAYDCDQLCYCTGSNVV-IKSLSSNAKQNAWKAHDGVVLKVDWSPINHLIITGGEDCK 209 Query: 243 VKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVR 302 K+WD G + F + V + P+ L A+ + ++ D + + Sbjct: 210 YKVWD-SFGRLLFQSGLFDYPVTSVAWAPSGE--LFAVGGFNTLQLCDRMGWAYSKIHLN 266 Query: 303 DETDYMTLEW 312 D MTL W Sbjct: 267 DTGSIMTLSW 276 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 43/247 (17%), Positives = 86/247 (34%), Gaps = 23/247 (9%) Query: 148 DWMISGDADGMIKIWQPNFSMVKE-------IDAAHTESIRDMAFSSND-SKFVTCSDDN 199 + + + D I W ++ H + + F D Sbjct: 26 NELFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPVSSKKTQAGGTDVFAVACTDG 85 Query: 200 ILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILK 259 +KI + G+ E+ + GH S W + +A+A +D VK+W R+G S++ + Sbjct: 86 SVKILS-RTGRVEKSIEGHKGACISLRWSYDGTALATAGEDGSVKIW-SRNGMLRSTLAQ 143 Query: 260 FKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESM 319 V + L + + + + K+ + + ++W PIN + Sbjct: 144 ADSPVYSIVWAYDCDQLCYCTGSNVVIK--SLSSNAKQNAWKAHDGVVLKVDWSPIN-HL 200 Query: 320 FTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRF--- 376 D K +D +L D +TS+++ P G +FA T++ Sbjct: 201 IITGGEDCKYKVWDSFG----RLLFQSGLFDYPVTSVAWAPSGELFAVGGF-NTLQLCDR 255 Query: 377 --WTRAR 381 W ++ Sbjct: 256 MGWAYSK 262 Score = 97.5 bits (241), Expect = 1e-20, Method: Composition-based stats. Identities = 41/222 (18%), Positives = 82/222 (36%), Gaps = 19/222 (8%) Query: 166 FSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSC 225 + + H+E + ++ ++ TCSDD + WN G+ E+ +S Sbjct: 3 LKVKQSSANVHSELTAAVGWNV-WNELFTCSDDQTIHKWNML-GEPEQKVSTLDAYFTDM 60 Query: 226 DWHP---------EMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNL 276 W+P + A A D VK+ R+G SI K + R+ G Sbjct: 61 HWYPVSSKKTQAGGTDVFAVACTDGSVKIL-SRTGRVEKSIEGHKGACISLRWS-YDGTA 118 Query: 277 LMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQ 336 L +D S +++ ++ + D Y + + ++ + ++ L Sbjct: 119 LATAGEDGSVKIWSRNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGS---NVVIKSLSS 175 Query: 337 NLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWT 378 N + AHD + + ++P+ H+ T +D + W Sbjct: 176 NAKQ---NAWKAHDGVVLKVDWSPINHLIITGGEDCKYKVWD 214 Score = 74.0 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 26/133 (19%), Positives = 50/133 (37%), Gaps = 15/133 (11%) Query: 255 SSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHP 314 SS + N L S D++ +++ ++ + D + + W+P Sbjct: 8 SSANVHSELTAAVGWNVW--NELFTCSDDQTIHKWNMLGEPEQKVSTLD-AYFTDMHWYP 64 Query: 315 INESM--------FTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFA 366 ++ F +AC DGS+K + H SL ++ G A Sbjct: 65 VSSKKTQAGGTDVFAVACTDGSVKILS----RTGRVEKSIEGHKGACISLRWSYDGTALA 120 Query: 367 TAAKDRTIRFWTR 379 TA +D +++ W+R Sbjct: 121 TAGEDGSVKIWSR 133 Score = 65.5 bits (158), Expect = 5e-11, Method: Composition-based stats. Identities = 25/200 (12%), Positives = 66/200 (33%), Gaps = 22/200 (11%) Query: 1 MDGHNQNQYQNQN------QIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLV 54 ++GH + + +K + R+ + S + ++V Sbjct: 100 IEGHKGACISLRWSYDGTALATAGEDGSVKIW---SRNGMLRSTLAQA----DSPVYSIV 152 Query: 55 VEPETSYTIDIMPPNAYRGRDRVI-NLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATY 113 + D G + VI +L S + V+ + W+P ++ Sbjct: 153 ------WAYDCDQLCYCTGSNVVIKSLSSNAKQNAWKAHDGVVLKVDWSPINHLIITGGE 206 Query: 114 SGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEID 173 ++ +W+ S D VT++ ++ + G +++ +I Sbjct: 207 DCKYKVWD-SFGRLLFQSGLFDYPVTSVAWAPSGELFAVGGF-NTLQLCDRMGWAYSKIH 264 Query: 174 AAHTESIRDMAFSSNDSKFV 193 T SI ++++++ ++ Sbjct: 265 LNDTGSIMTLSWTADSTQLA 284 >4G56-B nrPDB Length = 357 Score = 152 bits (384), Expect = 3e-37, Method: Composition-based stats. Identities = 59/279 (21%), Positives = 109/279 (39%), Gaps = 12/279 (4%) Query: 81 PSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWN----ASSFTFETLMQAHDS 136 P++ + + + + + W E + ++VA+ SG LW S + HD Sbjct: 82 PNESLCTAGVQTEAGVTDVAWVSE-KGILVASDSGAVELWEILEKESLLVNKFAKYEHDD 140 Query: 137 AVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSN-DSKFVTC 195 V T+ D +SG D +K+W + V + AH+ + +A D+ F++C Sbjct: 141 IVKTLSVFSDGTQAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSC 200 Query: 196 SDDNILKIWNFSNGKQERVLSGHHWDV--KSCDWHPEMGLIASASKD-NLVKLWDPRSGN 252 +D + +W+ K + D S WHPE + + V L + ++ + Sbjct: 201 GEDGRILLWDTRKPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLVNIKNPD 260 Query: 253 CISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMT-LE 311 + + + L +IS+D + V D +S E+ D++T + Sbjct: 261 SAQTSAVHSQNITGLAYSYHSSPFLASISEDCTVAVLDADFS--EVFRDLSHRDFVTGVA 318 Query: 312 WHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHD 350 W P++ S FT +D + H L L A D Sbjct: 319 WSPLDHSKFTTVGWDHKVLHHHLPSEGRTENLIATKAED 357 Score = 105 bits (262), Expect = 5e-23, Method: Composition-based stats. Identities = 40/226 (17%), Positives = 76/226 (33%), Gaps = 13/226 (5%) Query: 177 TESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSG----HHWDVKSCDWHPEMG 232 + D+A+ S V SD +++W + V H VK+ + Sbjct: 94 EAGVTDVAWVSEKGILV-ASDSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSDGT 152 Query: 233 LIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIR 292 S KD VK+WD + S V P K + ++ +D ++D R Sbjct: 153 QAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTR 212 Query: 293 YSMKELMCV--RDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHD 350 +T ++ WHP + F G++ ++ + H Sbjct: 213 KPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLVNIKNPDS---AQTSAVHS 269 Query: 351 KCITSLSYNPVGH-IFATAAKDRTIRFWTR--ARPIDPNAYDDPTY 393 + IT L+Y+ A+ ++D T+ + ++ D Sbjct: 270 QNITGLAYSYHSSPFLASISEDCTVAVLDADFSEVFRDLSHRDFVT 315 Score = 80.2 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 39/238 (16%), Positives = 78/238 (32%), Gaps = 13/238 (5%) Query: 12 QNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAY 71 + + S ++ + + S +N + H ++V Sbjct: 106 KGILVASDSGAVELWEILEKE----SLLVNKFAKYEH--DDIVKTLSVFSDGTQAVSGGK 159 Query: 72 RGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGR-RLVVATYSGEFSLWNASSFTFETL 130 +V +L K S N + + P + G LW+ T Sbjct: 160 DFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTRKPKPATR 219 Query: 131 --MQAHDSAVTTMKYSHDS-DWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSS 187 A D+ T++ + + D GD G + + + A H+++I +A+S Sbjct: 220 IDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLVNIKNPDSAQTSAVHSQNITGLAYSY 279 Query: 188 NDS-KFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHP-EMGLIASASKDNLV 243 + S + S+D + + + + R LS H V W P + + D+ V Sbjct: 280 HSSPFLASISEDCTVAVLDADFSEVFRDLS-HRDFVTGVAWSPLDHSKFTTVGWDHKV 336 >5WYJ-BE nrPDB Length = 939 Score = 149 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 63/377 (16%), Positives = 130/377 (34%), Gaps = 34/377 (9%) Query: 10 QNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHG-----------LPNLVV--- 55 Q+ + S+ L + R S + ++ G P +V Sbjct: 362 QSHFMLSASKDRSL--WSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFPEIVALAI 419 Query: 56 -EPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSS--NKVKHVIPAIQWTPEGRRLVVAT 112 +I+ + R ++ +K + + ++ + G + + Sbjct: 420 ENARIGEWENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGS 479 Query: 113 YSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEI 172 +G +++N S + H AVT + + M+S DG++ + N S + Sbjct: 480 SNGSITIYNMQSGILRKKYKLHKRAVTGISLDGMNRKMVSCGLDGIVGFYDFNKSTLLGK 539 Query: 173 DAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMG 232 I M + + F DD + + + + R L GH + + D+ PE Sbjct: 540 LKL-DAPITAMVYHRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSPEGR 598 Query: 233 LIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIR 292 I SAS D+ ++ WD +G CI I+ + +F P L ++ R Sbjct: 599 WIVSASLDSTIRTWDLPTGGCIDGII-VDNVATNVKFSPNGDLLATTHVTGNGICIWTNR 657 Query: 293 YSMKELMC-VRDETDYMTLEWHPI----NESMFTLACYDGS--------LKHFDLLQNLN 339 K + DE+++ + N+SM + A + L+ ++ Sbjct: 658 AQFKTVSTRTIDESEFARMALPSTSVRGNDSMLSGALESNGGEDLNDIDFNTYTSLEQID 717 Query: 340 EPILTIPYAHDKCITSL 356 + +LT+ + +L Sbjct: 718 KELLTLSIGPRSKMNTL 734 Score = 106 bits (265), Expect = 2e-23, Method: Composition-based stats. Identities = 60/415 (14%), Positives = 133/415 (32%), Gaps = 92/415 (22%) Query: 51 PNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGR-RLV 109 P+ + E + +DI+ G + N+ + + I ++ + +G L Sbjct: 206 PDQITTAEPAPVLDIIALGTVTGEVIMFNMRKGKRIRTIKIPQSRISSLSFRTDGSSHLS 265 Query: 110 VATYSGEFSLWNASSFTFETLMQ-AHD---SAVTTMKYSHDSDWMISGDADGMIK--IWQ 163 V T SG+ ++ + +++ H VT + + +++ D +K ++ Sbjct: 266 VGTSSGDLIFYDLDRRSRIHVLKNIHRESYGGVTQATFLNGQPIIVTSGGDNSLKEYVFD 325 Query: 164 PNFSM-----------VKEIDAAHTESIRDMAFSSNDSKF-VTCSDDNILKIW------- 204 P+ S H++ +AF+ + S F ++ S D L + Sbjct: 326 PSLSQGSGDVVVQPPRYLRSRGGHSQPPSYIAFADSQSHFMLSASKDRSLWSFSLRKDAQ 385 Query: 205 -----------------------------------NFSNGKQERVLSGHHWDVKSCDWHP 229 N G+ E +++ H + + W Sbjct: 386 SQEMSQRLHKKQDGGRVGGSTIKSKFPEIVALAIENARIGEWENIITAHKDEKFARTWDM 445 Query: 230 EMGLI-------------------------ASASKDNLVKLWDPRSGNCISSILKFKHTV 264 + S + + +++ +SG K V Sbjct: 446 RNKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSITIYNMQSGILRKKYKLHKRAV 505 Query: 265 LKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLAC 324 +++ D +D S L ++ + + +H ++ +F LA Sbjct: 506 TGISLD-GMNRKMVSCGLDGIVGFYDFNKS-TLLGKLKLDAPITAMVYHRSSD-LFALAL 562 Query: 325 YDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTR 379 D S+ D + + ++ + H IT+ ++P G +A+ D TIR W Sbjct: 563 DDLSIVVIDAVT---QRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTWDL 614 Score = 61.3 bits (147), Expect = 8e-10, Method: Composition-based stats. Identities = 44/305 (14%), Positives = 96/305 (31%), Gaps = 57/305 (18%) Query: 106 RRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSD-WMISGDADGMIKIWQP 164 + + T +GE ++N ++ S ++++ + D + G + G + + Sbjct: 219 DIIALGTVTGEVIMFNMRKGKRIRTIKIPQSRISSLSFRTDGSSHLSVGTSSGDLIFYDL 278 Query: 165 NF-SMVKEIDAAHT---ESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHW 220 + S + + H + F + VT DN LK Sbjct: 279 DRRSRIHVLKNIHRESYGGVTQATFLNGQPIIVTSGGDNSLK-----------------E 321 Query: 221 DVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAI 280 V + P + S D +V+ + S F ++ + +++ Sbjct: 322 YV----FDPSLSQ---GSGDVVVQ-----PPRYLRSRGGHSQPPSYIAFADSQSHFMLSA 369 Query: 281 SKDKSCRVFDIRYSMKE------LMCVRDETDY--------------MTLEWHPINES-- 318 SKD+S F +R + L +D + +E I E Sbjct: 370 SKDRSLWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFPEIVALAIENARIGEWEN 429 Query: 319 MFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWT 378 + T + + +D+ N T D + S++ + G+ + + +I + Sbjct: 430 IITAHKDEKFARTWDMR-NKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSITIYN 488 Query: 379 RARPI 383 I Sbjct: 489 MQSGI 493 >3JRO-A nrPDB Length = 753 Score = 149 bits (375), Expect = 3e-36, Method: Composition-based stats. Identities = 53/239 (22%), Positives = 86/239 (35%), Gaps = 25/239 (10%) Query: 172 IDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNF--SNGKQERVLSGHHWDVKSCDW-H 228 I AH E I D + TCS D +KI+ K L+GH V DW H Sbjct: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 Query: 229 PEMGLI-ASASKDNLVKLWDPRSGNCISSILK--FKHTVLKTRFQPTK-GNLLMAISKDK 284 P+ G I AS S D V +W +G + +V ++ P + G LL+ S D Sbjct: 64 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 Query: 285 SCRVFDIRYSMK--ELMCVRDETDYMTLEWHP------------INESMFTLACYDGSLK 330 V + + + ++ + W P F D +K Sbjct: 124 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 Query: 331 HFDLLQNLNEPIL-TIPYAHDKCITSLSYNPV---GHIFATAAKDRTIRFWTRARPIDP 385 + + +L + H + ++++P A+ ++DRT WT+ P Sbjct: 184 IWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGP 242 Score = 144 bits (362), Expect = 9e-35, Method: Composition-based stats. Identities = 47/292 (16%), Positives = 99/292 (33%), Gaps = 35/292 (11%) Query: 92 VKHVIPAIQWTPEGRRLVVATYSGEFSLWNAS--SFTFETLMQAHDSAVTTMKYSHD--S 147 +I G+RL + ++ + + H+ V + ++H Sbjct: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG 67 Query: 148 DWMISGDADGMIKIWQPNFSMVKEIDAA--HTESIRDMAFSSN--DSKFVTCSDDNILKI 203 + S DG + IW+ +I H+ S+ + ++ + + S D + + Sbjct: 68 TILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 127 Query: 204 WNFSNGKQER--VLSGHHWDVKSCDWHP-------------EMGLIASASKDNLVKLW-- 246 F ++ H V S W P E + DNLVK+W Sbjct: 128 VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 187 Query: 247 --DPRSGNCISSILKFKHTVLKTRFQPT--KGNLLMAISKDKSCRVF----DIRYSMKEL 298 D ++ S++ V + PT + L ++S+D++C ++ + K L Sbjct: 188 NSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTL 247 Query: 299 MCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHD 350 + D + ++ ++ L+ D + + +NL H Sbjct: 248 LKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW--KENLEGKWEPAGEVHQ 297 Score = 125 bits (313), Expect = 5e-29, Method: Composition-based stats. Identities = 45/276 (16%), Positives = 87/276 (31%), Gaps = 30/276 (10%) Query: 133 AHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVK--EIDAAHTESIRDMAF--SSN 188 AH+ + + + + +D IKI++ K + H + + + Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 189 DSKFVTCSDDNILKIWNFSNG--KQERVLSGHHWDVKSCDWHPE--MGLIASASKDNLVK 244 + +CS D + IW NG Q V + H V S W P L+ AS D V Sbjct: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 Query: 245 LWDPRSGNCIS--SILKFKHTVLKTRFQP------------TKGNLLMAISKDKSCRVFD 290 + + + S I V + P + + D +++ Sbjct: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 Query: 291 IRYSMKEL---MCVRDETDYMT-LEWHPIN--ESMFTLACYDGSLKHF--DLLQNLNEPI 342 + + +D++ + W P S D + + D Q + Sbjct: 187 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKT 246 Query: 343 LTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWT 378 L + S++ G++ A + D + W Sbjct: 247 LLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 Score = 98.7 bits (244), Expect = 5e-21, Method: Composition-based stats. Identities = 29/190 (15%), Positives = 62/190 (32%), Gaps = 20/190 (10%) Query: 216 SGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPR--SGNCISSILKFKHTVLKTRF-QPT 272 + H+ + +A+ S D +K+++ + I ++ + V + + P Sbjct: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 Query: 273 KGNLLMAISKDKSCRVFDIRYSMKELMCVR--DETDYMTLEWHPIN-ESMFTLACYDGSL 329 G +L + S D ++ + V +++W P + +A DG + Sbjct: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125 Query: 330 KHFDLLQNLNEPILTIPYAHDKCITSLSYNP-------------VGHIFATAAKDRTIRF 376 + +N + I AH + S S+ P F T D ++ Sbjct: 126 SVVEFKENGTTSPI-IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 184 Query: 377 WTRARPIDPN 386 W Sbjct: 185 WKYNSDAQTY 194 Score = 81.7 bits (200), Expect = 6e-16, Method: Composition-based stats. Identities = 29/239 (12%), Positives = 69/239 (28%), Gaps = 41/239 (17%) Query: 1 MDGHNQNQYQNQN--------QIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPN 52 + GH ++ S + + + I ++ + + Sbjct: 49 LTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENG----RWSQIAVHAVHSASVNS 104 Query: 53 LVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHV--IPAIQWTP------- 103 + P ++ + G+ V+ T H + + W P Sbjct: 105 VQWAPH--EYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDG 162 Query: 104 ------EGRRLVVATYSGEFSLW----NASSFTFETLMQAHDSAVTTMKYSHD---SDWM 150 E R+ V +W +A ++ E+ ++ H V + +S ++ Sbjct: 163 EHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYL 222 Query: 151 ISGDADGMIKIWQPNFSM---VKEIDAAHT--ESIRDMAFSSNDSKFVTCSDDNILKIW 204 S D IW + K + + + ++S + + DN + +W Sbjct: 223 ASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 39.3 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 14/67 (20%), Positives = 23/67 (34%), Gaps = 4/67 (5%) Query: 343 LTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARP----IDPNAYDDPTYNNKKI 398 + I AH++ I + G AT + D+TI+ + ID + Sbjct: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 Query: 399 NGWFFGI 405 FG Sbjct: 62 AHPKFGT 68 >4L9O-A nrPDB Length = 349 Score = 142 bits (358), Expect = 3e-34, Method: Composition-based stats. Identities = 53/226 (23%), Positives = 89/226 (39%), Gaps = 17/226 (7%) Query: 171 EIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIW--NFSNGKQERVLSGHHWDVKSCDW- 227 I AH + I D + TCS D +KI+ + N + L GH V W Sbjct: 63 TIGNAHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWA 122 Query: 228 HPEMGLI-ASASKDNLVKLWDPRSG--NCISSILKFKHTVLKTRFQPTK-GNLLMAISKD 283 HP+ G+I AS S D V +W +G N ++ + +V + P + G +L+ S D Sbjct: 123 HPKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSD 182 Query: 284 KSCRVFDIRYS--MKELMCVRDETDYMTLEWHPI----NESMFTLACYDGSLKHFDLLQN 337 + + + ++ ++ W PI N F D +K + Sbjct: 183 GKISIVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDA 242 Query: 338 LNEPI-LTIPYAHDKCITSLSYNP---VGHIFATAAKDRTIRFWTR 379 I H + ++++P ATA++DRT+ WT+ Sbjct: 243 AKTFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTK 288 Score = 132 bits (332), Expect = 3e-31, Method: Composition-based stats. Identities = 40/266 (15%), Positives = 90/266 (33%), Gaps = 25/266 (9%) Query: 92 VKHVIPAIQWTPEGRRLVVATYSGEFSLW--NASSFTFETLMQAHDSAVTTMKYSHD--S 147 +I GRRL + ++ + + + H+ V + ++H Sbjct: 68 HDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKFG 127 Query: 148 DWMISGDADGMIKIWQPNFSMVKEIDAA--HTESIRDMAFSSN--DSKFVTCSDDNILKI 203 + S DG + IW+ + + ++ H S+ ++++ + + S D + I Sbjct: 128 VILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISI 187 Query: 204 WNFSNGKQER--VLSGHHWDVKSCDWHP-----EMGLIASASKDNLVKLWDPRSGNCI-- 254 F +G V+ GH V + W P S DNLVK+W Sbjct: 188 VEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFI 247 Query: 255 --SSILKFKHTVLKTRFQPT--KGNLLMAISKDKSCRVF----DIRYSMKELMCVRDETD 306 + V + P+ + + S+D++ ++ K+ + D Sbjct: 248 EEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPD 307 Query: 307 YMTLEWHPINESMFTLACYDGSLKHF 332 ++ ++ ++ D + + Sbjct: 308 VCWRASWSLSGNVLAISGGDNKVTLW 333 Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats. Identities = 47/268 (17%), Positives = 93/268 (34%), Gaps = 22/268 (8%) Query: 133 AHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVK--EIDAAHTESIRDMAF--SSN 188 AHD + + + + +D IKI++ + + E H + +A+ Sbjct: 67 AHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKF 126 Query: 189 DSKFVTCSDDNILKIWNFSNG--KQERVLSGHHWDVKSCDWHPE--MGLIASASKDNLVK 244 +CS D + IW NG + S H V S W P ++ AS D + Sbjct: 127 GVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKIS 186 Query: 245 LWDPRSGNCIS--SILKFKHTVLKTRFQ----PTKGNLLMAISKDKSCRVF---DIRYSM 295 + + + G + I V + P ++ D +++ D + Sbjct: 187 IVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTF 246 Query: 296 KELMCVRDETDYMT-LEWHP--INESMFTLACYDGSLKHF--DLLQNLNEPILTIPYAHD 350 E + +D++ + W P +++S A D ++ + D N E Sbjct: 247 IEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFP 306 Query: 351 KCITSLSYNPVGHIFATAAKDRTIRFWT 378 S++ G++ A + D + W Sbjct: 307 DVCWRASWSLSGNVLAISGGDNKVTLWK 334 Score = 119 bits (297), Expect = 4e-27, Method: Composition-based stats. Identities = 47/265 (17%), Positives = 102/265 (38%), Gaps = 28/265 (10%) Query: 52 NLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKH--VIPAIQW-TPE-GRR 107 +L+ + Y + + ++ + + L + H + + W P+ G Sbjct: 70 DLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKFGVI 129 Query: 108 LVVATYSGEFSLWNASSFTFETL--MQAHDSAVTTMKYSHD--SDWMISGDADGMIKI-- 161 L +Y G+ +W + + + H ++V ++ ++ ++ +DG I I Sbjct: 130 LASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISIVE 189 Query: 162 WQPNFSMVKEIDAAHTESIRDMAFSS-----NDSKFVTCSDDNILKIWNFSNGKQ----E 212 ++ ++ + H + +++ N +FV+ DN++KIW + + + E Sbjct: 190 FKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEE 249 Query: 213 RVLSGHHWDVKSCDWHP---EMGLIASASKDNLVKLW--DPRSGNCIS---SILKFKHTV 264 GH V+ W P IA+AS+D V +W D +S + KF Sbjct: 250 EAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVC 309 Query: 265 LKTRFQPTKGNLLMAISKDKSCRVF 289 + + GN+L D ++ Sbjct: 310 WRASWS-LSGNVLAISGGDNKVTLW 333 Score = 96.3 bits (238), Expect = 3e-20, Method: Composition-based stats. Identities = 26/190 (13%), Positives = 60/190 (31%), Gaps = 12/190 (6%) Query: 212 ERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKL--WDPRSGNCISSILKFKHTVLKTRF 269 + + H + +A+ S D +K+ D + + +++ + V + + Sbjct: 62 VTIGNAHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAW 121 Query: 270 -QPTKGNLLMAISKDKSCRVF--DIRYSMKELMCVRDETDYMTLEWHPIN-ESMFTLACY 325 P G +L + S D ++ D K + ++ W P + A Sbjct: 122 AHPKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASS 181 Query: 326 DGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNP-----VGHIFATAAKDRTIRFWTRA 380 DG + + + I H + + S+ P F + D ++ W Sbjct: 182 DGKISIVEFKDGGALEPIVI-QGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYD 240 Query: 381 RPIDPNAYDD 390 ++ Sbjct: 241 DAAKTFIEEE 250 Score = 47.8 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 10/92 (10%), Positives = 26/92 (28%), Gaps = 8/92 (8%) Query: 84 FTHLSSNKVKHVIPAIQWTPE---GRRLVVATYSGEFSLW--NASSFTFET---LMQAHD 135 + + + W+P + A+ +W + S +E + Sbjct: 247 IEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFP 306 Query: 136 SAVTTMKYSHDSDWMISGDADGMIKIWQPNFS 167 +S + + D + +W+ N Sbjct: 307 DVCWRASWSLSGNVLAISGGDNKVTLWKENIQ 338 Score = 40.1 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 15/81 (18%), Positives = 26/81 (32%), Gaps = 4/81 (4%) Query: 329 LKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTR----ARPID 384 + +TI AHD I + G AT + D+TI+ + R ++ Sbjct: 48 INIVGSGGGSGGGSVTIGNAHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVE 107 Query: 385 PNAYDDPTYNNKKINGWFFGI 405 + FG+ Sbjct: 108 TLIGHEGPVWQVAWAHPKFGV 128 >5A31-R nrPDB Length = 386 Score = 142 bits (358), Expect = 3e-34, Method: Composition-based stats. Identities = 53/308 (17%), Positives = 116/308 (37%), Gaps = 13/308 (4%) Query: 76 RVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHD 135 ++ +P + S I W+ L VA L + ++ L + Sbjct: 75 QIAKVPYRVLDAPSLADDFYYSLIDWS-STDVLAVAL-GKSIFLTDNNTGDVVHLCDTEN 132 Query: 136 SAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTC 195 T++ + + G A+G+++I+ + H + + +++ N+ + Sbjct: 133 EY-TSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSW--NNHVLTSG 189 Query: 196 SDDNILKIWNFSNGKQE-RVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCI 254 S D+ + + + H +V W+ +AS DN+V +++ S + I Sbjct: 190 SRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPI 249 Query: 255 SSILKFKHTVLKTRFQPTKGNLLMAIS--KDKSCRVFDIRYSMKELMCVRDETDYMTLEW 312 + + K V + P K +L D+ +++++ S+K + + + + W Sbjct: 250 LTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIK-MSDIDSGSQICNMVW 308 Query: 313 HPINESMFTLACYDG-SLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKD 371 + T Y +L +D N +PI I H + L+ + G + A D Sbjct: 309 SKNTNELVTSHGYSKYNLTLWDC--NSMDPI-AILKGHSFRVLHLTLSNDGTTVVSGAGD 365 Query: 372 RTIRFWTR 379 T+R+W Sbjct: 366 ETLRYWKL 373 Score = 120 bits (301), Expect = 1e-27, Method: Composition-based stats. Identities = 36/245 (14%), Positives = 86/245 (35%), Gaps = 9/245 (3%) Query: 97 PAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDAD 156 ++ W G L V +G +++ + H V + ++ + + SG D Sbjct: 135 TSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWN--NHVLTSGSRD 192 Query: 157 GMIKIWQPNF-SMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVL 215 I E +HT+ + + ++ D+K + +DN++ ++ ++ Sbjct: 193 HRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTF 252 Query: 216 SGHHWDVKSCDWHPEM-GLIASAS--KDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPT 272 H VK+ W P G++A+ D +K+W+ + +S I + Sbjct: 253 DEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMV-WSKN 311 Query: 273 KGNLLMAIS-KDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKH 331 L+ + + ++D + + L + + D +L++ Sbjct: 312 TNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLS-NDGTTVVSGAGDETLRY 370 Query: 332 FDLLQ 336 + L Sbjct: 371 WKLFD 375 Score = 70.2 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 23/156 (14%), Positives = 61/156 (39%), Gaps = 6/156 (3%) Query: 66 MPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVV---ATYSGEFSLWNA 122 + V SK L+ ++ K + A+ W+P R ++ T +WN Sbjct: 229 LASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNV 288 Query: 123 SSFTFETLMQAHDSAVTTMKYSHDSDWMIS--GDADGMIKIWQPNFSMVKEIDAAHTESI 180 ++ + + + + +S +++ +++ G + + +W N I H+ + Sbjct: 289 NTSIKMSDIDSGSQICNMV-WSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRV 347 Query: 181 RDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLS 216 + S++ + V+ + D L+ W + + + Sbjct: 348 LHLTLSNDGTTVVSGAGDETLRYWKLFDVSVLNLFT 383 Score = 55.9 bits (133), Expect = 4e-08, Method: Composition-based stats. Identities = 25/177 (14%), Positives = 54/177 (30%), Gaps = 10/177 (5%) Query: 225 CDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDK 284 DW + + + + L D +G+ + + ++ + G+ L + Sbjct: 98 IDWS--STDVLAVALGKSIFLTDNNTGDVVH-LCDTENEYTSLSWI-GAGSHLAVGQANG 153 Query: 285 SCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILT 344 ++D+ L W N + T D + H D+ + +P Sbjct: 154 LVEIYDVMKRKCIRTLSGHIDRVACLSW---NNHVLTSGSRDHRILHRDVR--MPDPFFE 208 Query: 345 IPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGW 401 +H + + L +N + A+ D + + P D K W Sbjct: 209 TIESHTQEVCGLKWNVADNKLASGGNDNVVHVYE-GTSKSPILTFDEHKAAVKAMAW 264 >6BX3-A nrPDB Length = 314 Score = 142 bits (357), Expect = 4e-34, Method: Composition-based stats. Identities = 50/303 (16%), Positives = 116/303 (38%), Gaps = 27/303 (8%) Query: 97 PAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLM-QAHDSAVTTMKYSHDSDWMISGDA 155 + +P+G+ L + T +++ + T + +H + + +S D + + Sbjct: 16 TCAKISPDGQFLAI-TQGLNILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASD 74 Query: 156 DGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVL 215 D ++I ++ ++ HT + + F+ + T S D +KIW+ NG + + Sbjct: 75 DFSVEIIHLSYGLLHTFI-GHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTI 133 Query: 216 SGHHWDVKSCDW-HPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHT--------VLK 266 S H V S D + +++S S D L++++D +G+C+ ++ K + + Sbjct: 134 SAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQ 193 Query: 267 TRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPIN---------- 316 +F LL+ S D +++D + + + + H Sbjct: 194 VKFSENARYLLV-KSLDGVVKIWDC-IGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGS 251 Query: 317 ESMFTLACYDGSLKHFDLLQNLNEPILT-IPYAHDKCITSLSYNPVGHIFATAAKDRTIR 375 + +G + ++ +L Y H + S+ + G+I + A + Sbjct: 252 TPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSI--HCFGNIMCSLALNGDCC 309 Query: 376 FWT 378 W Sbjct: 310 LWR 312 Score = 118 bits (296), Expect = 4e-27, Method: Composition-based stats. Identities = 45/279 (16%), Positives = 99/279 (35%), Gaps = 31/279 (11%) Query: 36 SSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHV 95 + L + L P+ + + +I+L H + Sbjct: 43 RTVSQTLVTSHARPFSELCWSPDGQ----CIATASDDFSVEIIHLSYGLLH-TFIGHTAP 97 Query: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYS-HDSDWMISGD 154 + ++ + +G L ++ +W+ + + + AH AV ++ +DS + SG Sbjct: 98 VISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGS 157 Query: 155 ADGMIKIWQPNFSMVKEIDAAHTES--------IRDMAFSSNDSKFVTCSDDNILKIWNF 206 DG+I+I+ + + I + FS N + S D ++KIW+ Sbjct: 158 YDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDC 217 Query: 207 SNGKQERVLS------GHHWDVKSCDW-HPEMG---LIASASKDNLVKLWDPRSGNCIS- 255 G R G D+ +PE G L+ S ++ + W+ + + + Sbjct: 218 IGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQL 277 Query: 256 ---SILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDI 291 S+ V+ GN++ +++ + C ++ Sbjct: 278 LDGSLYHHSSPVMSIHCF---GNIMCSLALNGDCCLWRW 313 Score = 64.8 bits (156), Expect = 8e-11, Method: Composition-based stats. Identities = 23/125 (18%), Positives = 54/125 (43%), Gaps = 6/125 (4%) Query: 256 SILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDI-RYSMKELMCVRDETDYMTLEWHP 314 + + ++ + T + + +AI++ + ++DI R ++ + + + L W P Sbjct: 5 TPVGTQNGLKATCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTSHARPFSELCWSP 64 Query: 315 INESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTI 374 + A D S++ L +L H + SL++N G++ T++ D +I Sbjct: 65 DGQ-CIATASDDFSVEIIHLSYG----LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESI 119 Query: 375 RFWTR 379 + W Sbjct: 120 KIWDT 124 >5WBU-D nrPDB Length = 328 Score = 141 bits (356), Expect = 5e-34, Method: Composition-based stats. Identities = 50/239 (20%), Positives = 87/239 (36%), Gaps = 17/239 (7%) Query: 49 GLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSN-KVKHVIPAIQWTPEGRR 107 G+ + M R+ +L S+ +V I + P Sbjct: 85 GVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAE 144 Query: 108 LVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFS 167 L+V SG +W+ + E L+ + ++T+ D+ +M + ++ G +W Sbjct: 145 LIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGG 204 Query: 168 --------MVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIW---NFSNGKQERVLS 216 + K AHT FS + + TCS D KIW NFS + + S Sbjct: 205 IGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKS 264 Query: 217 GHHWD-----VKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQ 270 G+ + + C + + I +AS DNL +LW +G + V+ F Sbjct: 265 GNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 323 Score = 141 bits (354), Expect = 9e-34, Method: Composition-based stats. Identities = 42/315 (13%), Positives = 99/315 (31%), Gaps = 19/315 (6%) Query: 107 RLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNF 166 L A Y W A S +Q DS V ++ + D + + I+++ N Sbjct: 16 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNS 74 Query: 167 SMVKEIDA--AHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQE-RVLSGHHWDVK 223 + I + ++I + F + T +D +IW+ + + + + + + Sbjct: 75 NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPIN 134 Query: 224 SCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKD 283 HP + + + +WD ++ + I + + ++ P + + A++ Sbjct: 135 CVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDP-DASYMAAVNST 193 Query: 284 KSCRVFDIRYS-------MKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQ 336 +C V+++ + + T Y + ++ D + K + Sbjct: 194 GNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 253 Query: 337 NLNEPILTIPYAH-----DKCITSLSYNPVGHIFATAAKDRTIRFW--TRARPIDPNAYD 389 L+I + + +++ TA+ D R W Sbjct: 254 FSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGH 313 Query: 390 DPTYNNKKINGWFFG 404 N G Sbjct: 314 QKAVVCLAFNDSVLG 328 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 40/252 (15%), Positives = 82/252 (32%), Gaps = 31/252 (12%) Query: 1 MDGHNQN------QYQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLV 54 DG N+N + + + + + R++ + + + Sbjct: 83 YDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQC-----QRIFQVNAPINCVC 137 Query: 55 VEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYS 114 + P + I G + +L + + + I + P+ + + Sbjct: 138 LHPNQAELI----VGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNST 193 Query: 115 GEFSLWNASSFTF--------ETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIW---Q 163 G +WN + +T + AH ++S DS + + AD KIW Sbjct: 194 GNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 253 Query: 164 PNFSMVKEIDAAH-----TESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGH 218 + I + + + AFS + VT S DN+ ++W G+ +R GH Sbjct: 254 FSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGH 313 Query: 219 HWDVKSCDWHPE 230 V ++ Sbjct: 314 QKAVVCLAFNDS 325 Score = 124 bits (312), Expect = 6e-29, Method: Composition-based stats. Identities = 48/315 (15%), Positives = 101/315 (32%), Gaps = 27/315 (8%) Query: 65 IMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASS 124 I+ Y R S + + A++ TP+ + A Y +++ +S Sbjct: 16 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNS 74 Query: 125 FTFETLMQ--AHDSAVTTMKYSHDSDWMISGDADGMIKIWQP---NFSMVKEIDAAHTES 179 ++ + + ++ + D WM +G D +IW N + Sbjct: 75 NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV--NAP 132 Query: 180 IRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASK 239 I + N ++ + + IW+ E+++ + S P+ +A+ + Sbjct: 133 INCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNS 192 Query: 240 DNLVKLWDPRSG--------NCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDI 291 +W+ G + I L+ RF P LL S D++C+++ Sbjct: 193 TGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DSTLLATCSADQTCKIWRT 251 Query: 292 RY-------SMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILT 344 S+K +M + A D + + + I Sbjct: 252 SNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETG---EIKR 308 Query: 345 IPYAHDKCITSLSYN 359 H K + L++N Sbjct: 309 EYGGHQKAVVCLAFN 323 Score = 112 bits (279), Expect = 4e-25, Method: Composition-based stats. Identities = 44/284 (15%), Positives = 97/284 (34%), Gaps = 27/284 (9%) Query: 50 LPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTH--LSSNKVKHVIPAIQWTPEGRR 107 + L V P+ S M A R+ +L S + +S + V I ++ + +GR Sbjct: 47 VNALEVTPDRS-----MIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRW 101 Query: 108 LVVATYSGEFSLWNASSFT--FETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPN 165 + +W+ S + + Q ++ + + + +I GD G I IW Sbjct: 102 MYTGGEDCTARIWDLRSRNLQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLK 160 Query: 166 FSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGK--------QERVLSG 217 +++ SI + S + +WN + G + + Sbjct: 161 TDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPA 220 Query: 218 HHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSI--------LKFKHTVLKTRF 269 H C + P+ L+A+ S D K+W + + ++ + + + F Sbjct: 221 HTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAF 280 Query: 270 QPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWH 313 ++ S D R++ + + + + L ++ Sbjct: 281 S-GDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 323 Score = 30.1 bits (66), Expect = 2.0, Method: Composition-based stats. Identities = 12/41 (29%), Positives = 16/41 (39%), Gaps = 2/41 (4%) Query: 360 PVGHIFATAAKDRTIRFWTRARPI--DPNAYDDPTYNNKKI 398 I ATA D T+RFW I + D N ++ Sbjct: 12 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEV 52 >5K0Y-T nrPDB Length = 329 Score = 141 bits (354), Expect = 1e-33, Method: Composition-based stats. Identities = 50/251 (19%), Positives = 91/251 (36%), Gaps = 29/251 (11%) Query: 172 IDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEM 231 + H SI + ++ T + D I+ +W NG++ GH V D + Sbjct: 5 LLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDT 64 Query: 232 GLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDI 291 + + S DN +LWD +G ++ +LK V F ++ + K + F Sbjct: 65 KHVLTGSADNSCRLWDCETGKQLA-LLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVS 123 Query: 292 RYSMKELMCVRDETDYMTLEWHPINESMFTLACY------------DGSLKHFDLLQNLN 339 + +++ + + YM + P N+S T A + G L + Sbjct: 124 FFDLRDPSQIDNNEPYMKI---PCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSG-- 178 Query: 340 EPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWT----------RARPIDPNAYD 389 +L H + I + + +F TA+KD T + + R P A Sbjct: 179 -EVLVNVKEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFRTEPPRELAAL 237 Query: 390 DPTYNNKKING 400 P Y + + G Sbjct: 238 SPNYEHVVVGG 248 Score = 124 bits (311), Expect = 8e-29, Method: Composition-based stats. Identities = 43/313 (13%), Positives = 102/313 (32%), Gaps = 26/313 (8%) Query: 86 HLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSH 145 + + I I++ EG L ++W + + H AV + Sbjct: 3 PILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADW 62 Query: 146 DSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNI----- 200 D+ +++G AD ++W + ++R F + + S D Sbjct: 63 DTKHVLTGSADNSCRLWDCETGKQLALLK-TNSAVRTCGFDFGGNIIMF-STDKQMGYQC 120 Query: 201 -LKIWNFS------NGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNC 253 + ++ N + + + + S W P I + + + + +SG Sbjct: 121 FVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEV 180 Query: 254 ISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWH 313 + ++ + + + + + + SKD + ++FD +++ R E Sbjct: 181 LVNVKEHSRQINDIQLS-REMTMFVTASKDNTAKLFD-STTLEHQKTFRTEPPRELAALS 238 Query: 314 PINESMFTLAC--------YDGSLKHFDLLQNLN--EPILTIPYAHDKCITSLSYNPVGH 363 P E + + F+ E H I S++++P G Sbjct: 239 PNYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGK 298 Query: 364 IFATAAKDRTIRF 376 +++ +D +R Sbjct: 299 SYSSGGEDGYVRI 311 Score = 84.4 bits (207), Expect = 8e-17, Method: Composition-based stats. Identities = 34/276 (12%), Positives = 87/276 (31%), Gaps = 41/276 (14%) Query: 88 SSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDS 147 + + + + + ++ + LW+ + L++ +SAV T + Sbjct: 47 TYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKT-NSAVRTCGFDFGG 105 Query: 148 DWMISGDADGM------IKIWQP------NFSMVKEIDAAHTESIRDMAFSSNDSKFVTC 195 + ++ D + + + + + I + + Sbjct: 106 NIIMF-STDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAG 164 Query: 196 SDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCIS 255 + L ++ +G+ + H + EM + +ASKDN KL+D S Sbjct: 165 HESGELNQYSAKSGEVLVNVKEHSRQINDIQLSREMTMFVTASKDNTAKLFD-------S 217 Query: 256 SILKFKHTVLK------TRFQPTKGNLLMAIS---KDKS----------CRVFDIRYSMK 296 + L+ + T P ++++ D + R F + + + Sbjct: 218 TTLEHQKTFRTEPPRELAALSPNYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEE 277 Query: 297 ELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHF 332 ++ +HP +S ++ DG ++ Sbjct: 278 FGRVKGHFGPINSVAFHPDGKS-YSSGGEDGYVRIH 312 Score = 82.9 bits (203), Expect = 3e-16, Method: Composition-based stats. Identities = 29/181 (16%), Positives = 67/181 (37%), Gaps = 17/181 (9%) Query: 80 LPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVT 139 + + ++ I + W P G ++ SGE + ++A S ++ H + Sbjct: 133 IDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQIN 192 Query: 140 TMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDM-AFSSNDSKFVTCSD- 197 ++ S + ++ D K++ ++ TE R++ A S N V Sbjct: 193 DIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFR--TEPPRELAALSPNYEHVVVGGGQ 250 Query: 198 ---DNI----------LKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVK 244 D + ++ + ++ + GH + S +HP+ +S +D V+ Sbjct: 251 EAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVR 310 Query: 245 L 245 + Sbjct: 311 I 311 Score = 60.1 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 23/199 (11%), Positives = 56/199 (28%), Gaps = 18/199 (9%) Query: 26 YVTQRRSVDVSSPYINLYYNRRHGLP---NLVVEPETSYTIDIMPPNAYRGRDRVINLPS 82 Y D+ P +P + + + + G + S Sbjct: 118 YQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKS 177 Query: 83 KFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMK 142 ++ + I IQ + E V A+ L+++++ + + + Sbjct: 178 GEVLVNVKEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFRT-EPPRELAA 236 Query: 143 YSHDSDWMISGDA--------------DGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSN 188 S + + ++ G + + F H I +AF + Sbjct: 237 LSPNYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPD 296 Query: 189 DSKFVTCSDDNILKIWNFS 207 + + +D ++I F Sbjct: 297 GKSYSSGGEDGYVRIHYFD 315 >4BH6-A nrPDB Length = 308 Score = 140 bits (353), Expect = 1e-33, Method: Composition-based stats. Identities = 53/308 (17%), Positives = 116/308 (37%), Gaps = 13/308 (4%) Query: 76 RVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHD 135 ++ +P + S I W+ L VA L + ++ L + Sbjct: 6 QIAKVPYRVLDAPSLADDFYYSLIDWS-STDVLAVAL-GKSIFLTDNNTGDVVHLCDTEN 63 Query: 136 SAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTC 195 T++ + + G A+G+++I+ + H + + +++ N+ + Sbjct: 64 EY-TSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSW--NNHVLTSG 120 Query: 196 SDDNILKIWNFSNGKQE-RVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCI 254 S D+ + + + H +V W+ +AS DN+V +++ S + I Sbjct: 121 SRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPI 180 Query: 255 SSILKFKHTVLKTRFQPTKGNLLMAIS--KDKSCRVFDIRYSMKELMCVRDETDYMTLEW 312 + + K V + P K +L D+ +++++ S+K + + + + W Sbjct: 181 LTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIK-MSDIDSGSQICNMVW 239 Query: 313 HPINESMFTLACYDG-SLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKD 371 + T Y +L +D N +PI I H + L+ + G + A D Sbjct: 240 SKNTNELVTSHGYSKYNLTLWDC--NSMDPI-AILKGHSFRVLHLTLSNDGTTVVSGAGD 296 Query: 372 RTIRFWTR 379 T+R+W Sbjct: 297 ETLRYWKL 304 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 36/247 (14%), Positives = 86/247 (34%), Gaps = 9/247 (3%) Query: 97 PAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDAD 156 ++ W G L V +G +++ + H V + ++ + + SG D Sbjct: 66 TSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWN--NHVLTSGSRD 123 Query: 157 GMIKIWQPNF-SMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVL 215 I E +HT+ + + ++ D+K + +DN++ ++ ++ Sbjct: 124 HRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTF 183 Query: 216 SGHHWDVKSCDWHPEM-GLIASAS--KDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPT 272 H VK+ W P G++A+ D +K+W+ + +S I + Sbjct: 184 DEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMV-WSKN 242 Query: 273 KGNLLMAIS-KDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKH 331 L+ + + ++D + + L + + D +L++ Sbjct: 243 TNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLS-NDGTTVVSGAGDETLRY 301 Query: 332 FDLLQNL 338 + L Sbjct: 302 WKLFDKP 308 Score = 55.1 bits (131), Expect = 7e-08, Method: Composition-based stats. Identities = 25/177 (14%), Positives = 54/177 (30%), Gaps = 10/177 (5%) Query: 225 CDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDK 284 DW + + + + L D +G+ + + ++ + G+ L + Sbjct: 29 IDWS--STDVLAVALGKSIFLTDNNTGDVVH-LCDTENEYTSLSWI-GAGSHLAVGQANG 84 Query: 285 SCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILT 344 ++D+ L W N + T D + H D+ + +P Sbjct: 85 LVEIYDVMKRKCIRTLSGHIDRVACLSW---NNHVLTSGSRDHRILHRDVR--MPDPFFE 139 Query: 345 IPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGW 401 +H + + L +N + A+ D + + P D K W Sbjct: 140 TIESHTQEVCGLKWNVADNKLASGGNDNVVHVYE-GTSKSPILTFDEHKAAVKAMAW 195 >3JRP-A nrPDB Length = 379 Score = 140 bits (353), Expect = 1e-33, Method: Composition-based stats. Identities = 53/239 (22%), Positives = 86/239 (35%), Gaps = 25/239 (10%) Query: 172 IDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNF--SNGKQERVLSGHHWDVKSCDW-H 228 I AH E I D + TCS D +KI+ K L+GH V DW H Sbjct: 6 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 65 Query: 229 PEMGLI-ASASKDNLVKLWDPRSGNCISSILK--FKHTVLKTRFQPTK-GNLLMAISKDK 284 P+ G I AS S D V +W +G + +V ++ P + G LL+ S D Sbjct: 66 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 125 Query: 285 SCRVFDIRYSMK--ELMCVRDETDYMTLEWHP------------INESMFTLACYDGSLK 330 V + + + ++ + W P F D +K Sbjct: 126 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 185 Query: 331 HFDLLQNLNEPIL-TIPYAHDKCITSLSYNPV---GHIFATAAKDRTIRFWTRARPIDP 385 + + +L + H + ++++P A+ ++DRT WT+ P Sbjct: 186 IWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGP 244 Score = 136 bits (341), Expect = 3e-32, Method: Composition-based stats. Identities = 47/292 (16%), Positives = 99/292 (33%), Gaps = 35/292 (11%) Query: 92 VKHVIPAIQWTPEGRRLVVATYSGEFSLWNAS--SFTFETLMQAHDSAVTTMKYSHD--S 147 +I G+RL + ++ + + H+ V + ++H Sbjct: 10 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG 69 Query: 148 DWMISGDADGMIKIWQPNFSMVKEIDAA--HTESIRDMAFSSN--DSKFVTCSDDNILKI 203 + S DG + IW+ +I H+ S+ + ++ + + S D + + Sbjct: 70 TILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 129 Query: 204 WNFSNGKQER--VLSGHHWDVKSCDWHP-------------EMGLIASASKDNLVKLW-- 246 F ++ H V S W P E + DNLVK+W Sbjct: 130 VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 189 Query: 247 --DPRSGNCISSILKFKHTVLKTRFQPT--KGNLLMAISKDKSCRVF----DIRYSMKEL 298 D ++ S++ V + PT + L ++S+D++C ++ + K L Sbjct: 190 NSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTL 249 Query: 299 MCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHD 350 + D + ++ ++ L+ D + + +NL H Sbjct: 250 LKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW--KENLEGKWEPAGEVHQ 299 Score = 118 bits (295), Expect = 6e-27, Method: Composition-based stats. Identities = 45/284 (15%), Positives = 89/284 (31%), Gaps = 30/284 (10%) Query: 125 FTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVK--EIDAAHTESIRD 182 + + AH+ + + + + +D IKI++ K + H + Sbjct: 1 GSMVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWR 60 Query: 183 MAF--SSNDSKFVTCSDDNILKIWNFSNG--KQERVLSGHHWDVKSCDWHPE--MGLIAS 236 + + + +CS D + IW NG Q V + H V S W P L+ Sbjct: 61 VDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLV 120 Query: 237 ASKDNLVKLWDPRSGNCIS--SILKFKHTVLKTRFQP------------TKGNLLMAISK 282 AS D V + + + S I V + P + + Sbjct: 121 ASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGA 180 Query: 283 DKSCRVFDIRYSMKEL---MCVRDETDYMT-LEWHPIN--ESMFTLACYDGSLKHF--DL 334 D +++ + + +D++ + W P S D + + D Sbjct: 181 DNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDN 240 Query: 335 LQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWT 378 Q + L + S++ G++ A + D + W Sbjct: 241 EQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 284 Score = 93.7 bits (231), Expect = 2e-19, Method: Composition-based stats. Identities = 30/197 (15%), Positives = 64/197 (32%), Gaps = 20/197 (10%) Query: 209 GKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPR--SGNCISSILKFKHTVLK 266 G + + H+ + +A+ S D +K+++ + I ++ + V + Sbjct: 1 GSMVVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWR 60 Query: 267 TRF-QPTKGNLLMAISKDKSCRVFDIRYSMKELMCVR--DETDYMTLEWHPIN-ESMFTL 322 + P G +L + S D ++ + V +++W P + + Sbjct: 61 VDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLV 120 Query: 323 ACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNP-------------VGHIFATAA 369 A DG + + +N + I AH + S S+ P F T Sbjct: 121 ASSDGKVSVVEFKENGTTSPI-IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGG 179 Query: 370 KDRTIRFWTRARPIDPN 386 D ++ W Sbjct: 180 ADNLVKIWKYNSDAQTY 196 Score = 76.3 bits (186), Expect = 3e-14, Method: Composition-based stats. Identities = 29/239 (12%), Positives = 69/239 (28%), Gaps = 41/239 (17%) Query: 1 MDGHNQNQYQNQN--------QIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPN 52 + GH ++ S + + + I ++ + + Sbjct: 51 LTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENG----RWSQIAVHAVHSASVNS 106 Query: 53 LVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHV--IPAIQWTP------- 103 + P ++ + G+ V+ T H + + W P Sbjct: 107 VQWAPH--EYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDG 164 Query: 104 ------EGRRLVVATYSGEFSLW----NASSFTFETLMQAHDSAVTTMKYSHD---SDWM 150 E R+ V +W +A ++ E+ ++ H V + +S ++ Sbjct: 165 EHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYL 224 Query: 151 ISGDADGMIKIWQPNFSM---VKEIDAAHT--ESIRDMAFSSNDSKFVTCSDDNILKIW 204 S D IW + K + + + ++S + + DN + +W Sbjct: 225 ASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 283 Score = 47.4 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 14/111 (12%), Positives = 32/111 (28%), Gaps = 13/111 (11%) Query: 65 IMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPE---GRRLVVATYSGEFSLW- 120 ++ Y + L S + + W+P L + +W Sbjct: 183 LVKIWKYNSDAQTYVLESTLE-----GHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 237 Query: 121 --NASSFTFETLMQAHDSA--VTTMKYSHDSDWMISGDADGMIKIWQPNFS 167 N +TL++ + +S + + D + +W+ N Sbjct: 238 QDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLE 288 Score = 37.8 bits (86), Expect = 0.011, Method: Composition-based stats. Identities = 14/67 (20%), Positives = 23/67 (34%), Gaps = 4/67 (5%) Query: 343 LTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARP----IDPNAYDDPTYNNKKI 398 + I AH++ I + G AT + D+TI+ + ID + Sbjct: 4 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 63 Query: 399 NGWFFGI 405 FG Sbjct: 64 AHPKFGT 70 >3JB9-g nrPDB Length = 558 Score = 138 bits (348), Expect = 4e-33, Method: Composition-based stats. Identities = 43/303 (14%), Positives = 103/303 (33%), Gaps = 17/303 (5%) Query: 88 SSNKVKHVIPAIQWTP-EGRRLVVATYSGEFSLWNASSF-TFETLMQAHDSAVTTMKYSH 145 + I +++ P G L+ + + +W + Q H + + +S Sbjct: 261 TWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQ 320 Query: 146 DSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAF--SSND-SKFVTCSDDNILK 202 D +S D IK+W + + F + ++F+ + D + Sbjct: 321 DGRSFLSTSFDKTIKLWDTELGKCLNCFNS-DRLTNCVKFQVDPDKPNEFLAGTADKRIL 379 Query: 203 IWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFK- 261 ++ + + H + S + + S D+ ++ W+ + I + Sbjct: 380 QFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYGTPVPIKFVADIAM 439 Query: 262 HTVLKTRFQPTKGNLLMAISKDKSCRVFDI----RYSMKELMCVRDETDYMTLEWHPINE 317 H++ + +P G + S D V+ R + K++ + Y + Sbjct: 440 HSMPRVALRP-NGKSIACQSLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYSLEVGFSPDG 498 Query: 318 SMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNP-VGHIFATAA-KDRTIR 375 G+ +D ++ AH + S++++P AT++ D +I+ Sbjct: 499 RFVFSGDSSGNACFWDW---KTCKLMAKLPAHSGPVQSMAFHPQETSKVATSSIVDGSIK 555 Query: 376 FWT 378 +W Sbjct: 556 YWD 558 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 45/217 (20%), Positives = 77/217 (35%), Gaps = 8/217 (3%) Query: 174 AAHTESIRDMAFSS-NDSKFVTCSDDNILKIWNFSNG-KQERVLSGHHWDVKSCDWHPEM 231 HT+ I + F + ++ S DN +KIW + R GH ++ + + Sbjct: 263 KGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQDG 322 Query: 232 GLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRF--QPTKGNLLMAISKDKSCRVF 289 S S D +KLWD G C++ + T +F P K N +A + DK F Sbjct: 323 RSFLSTSFDKTIKLWDTELGKCLNCFNSDRLT-NCVKFQVDPDKPNEFLAGTADKRILQF 381 Query: 290 DIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAH 349 DIR ++ + N F D S++ ++ + + H Sbjct: 382 DIRSPDIVQAYDHHLGGINSITFL-ENGKRFVTTSDDSSMRFWEYGTPVPIKFVADIAMH 440 Query: 350 DKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPN 386 ++ P G A + D I ++ N Sbjct: 441 SMP--RVALRPNGKSIACQSLDNCIYVYSAYEKYRQN 475 Score = 97.5 bits (241), Expect = 1e-20, Method: Composition-based stats. Identities = 36/250 (14%), Positives = 78/250 (31%), Gaps = 22/250 (8%) Query: 9 YQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLY-YNRRHGLPNLVVEPETSYTIDIMP 67 ++ + S +K + T+ L +N + + + + + Sbjct: 320 QDGRSFLSTSFDKTIKLWDTELGKC--------LNCFNSDRLTNCVKFQVDPDKPNEFLA 371 Query: 68 PNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSF-- 125 R ++ S + + I +I + G+R V + W + Sbjct: 372 -GTADKRILQFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYGTPVP 430 Query: 126 -TFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQP---NFSMVKEIDAAHTESIR 181 F + H + + + D I ++ K++ ++ S Sbjct: 431 IKFVADIAMHSMP--RVALRPNGKSIACQSLDNCIYVYSAYEKYRQNKKKVFKGYSCSGY 488 Query: 182 D--MAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHP-EMGLIASAS 238 + FS + + W++ K L H V+S +HP E +A++S Sbjct: 489 SLEVGFSPDGRFVFSGDSSGNACFWDWKTCKLMAKLPAHSGPVQSMAFHPQETSKVATSS 548 Query: 239 K-DNLVKLWD 247 D +K WD Sbjct: 549 IVDGSIKYWD 558 Score = 81.7 bits (200), Expect = 7e-16, Method: Composition-based stats. Identities = 31/190 (16%), Positives = 68/190 (35%), Gaps = 14/190 (7%) Query: 256 SILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPI 315 + + RF P G+LL++ S D +++++ + L + + Sbjct: 261 TWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQ 320 Query: 316 NESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSY--NPV-GHIFATAAKDR 372 + F +D ++K +D D+ + + +P + F D+ Sbjct: 321 DGRSFLSTSFDKTIKLWDTELGKCLNCFNS----DRLTNCVKFQVDPDKPNEFLAGTADK 376 Query: 373 TIRFWTRARP--IDPNAYDDPTYNNKKI--NGWFFGINNDINAVREKSEFGAAPPPP--A 426 I + P + + N+ NG F +D +++R E+G P A Sbjct: 377 RILQFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMR-FWEYGTPVPIKFVA 435 Query: 427 TLEPHALPNM 436 + H++P + Sbjct: 436 DIAMHSMPRV 445 >5WLC-LJ nrPDB Length = 513 Score = 138 bits (347), Expect = 6e-33, Method: Composition-based stats. Identities = 55/304 (18%), Positives = 113/304 (37%), Gaps = 18/304 (5%) Query: 66 MPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSF 125 + P R ++T K + + I + P+ T S ++++ + Sbjct: 15 LLPQQTTPEQRYW---RQYTSAQLVKEHNSVTHISFNPQHPHDFAVTSSTRVQIFSSRTR 71 Query: 126 TFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQP-NFSMVKEIDAAHTESIRDMA 184 V + + D + +GDA G++ ++ N + A T Sbjct: 72 QVIKTFSRFKDVVYSASFRSDGKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTK 131 Query: 185 FSS-NDSKFVTCSDDNILKIWNFSNG-KQERVLSGHHWDVKSCDWHPEM-GLIASASKDN 241 F + ++ T SDD + ++W+ SN + + L+G V++ + P L+A+ S D Sbjct: 132 FHTQDNKILATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDG 191 Query: 242 LVKLWDPR-SGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMC 300 L++L+D R SG+ L V +++ + +V+D+ + K Sbjct: 192 LIRLYDTRSSGSTPIYSLNHDQPVENVI--AVSPTQIVSCGG-NNFKVWDLTSNKKLYER 248 Query: 301 VRDETDYMTLE----WHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSL 356 L+ + +S + DG +K FD L N + + + S Sbjct: 249 GNFNKAVTCLDYVENFDSPMQSALIASSLDGHVKVFDPLDNFQ---VKFGWKFSGPVLSC 305 Query: 357 SYNP 360 + +P Sbjct: 306 AVSP 309 Score = 98.3 bits (243), Expect = 6e-21, Method: Composition-based stats. Identities = 52/322 (16%), Positives = 112/322 (34%), Gaps = 19/322 (5%) Query: 52 NLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVK-HVIPAIQWT-PEGRRLV 109 ++V ++ G V + + T L S H ++ + + L Sbjct: 82 DVVYSASFRSDGKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFHTQDNKILA 141 Query: 110 VATYSGEFSLWNASS-FTFETLMQAHDSAVTTMKYSHDSDWM-ISGDADGMIKIWQPNFS 167 A+ LW+ S+ + + + V T+ + + + +G DG+I+++ S Sbjct: 142 TASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTRSS 201 Query: 168 MVKEIDAA-HTESI-RDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSC 225 I + H + + +A S + V+C +N K+W+ ++ K+ + V Sbjct: 202 GSTPIYSLNHDQPVENVIAVSPT--QIVSCGGNNF-KVWDLTSNKKLYERGNFNKAVTCL 258 Query: 226 DW-----HPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPT---KGNLL 277 D+ P + ++S D VK++DP + KF VL P+ L Sbjct: 259 DYVENFDSPMQSALIASSLDGHVKVFDPLDNFQVKFGWKFSGPVLSCAVSPSTAQGNRHL 318 Query: 278 MAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQN 337 +A + + + + + M + Y G +H ++ N Sbjct: 319 VAGLSSGLLAIRTKKKEKRSSDKENAPASFNKNAKSNNFQRMMRGSEYQGDQEH--IIHN 376 Query: 338 LNEPILTIPYAHDKCITSLSYN 359 A ++ I ++ Sbjct: 377 DKVRSQRRMRAFERNINQFKWS 398 Score = 77.5 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 36/182 (19%), Positives = 68/182 (37%), Gaps = 9/182 (4%) Query: 219 HWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLM 278 H V ++P+ + + V+++ R+ I + +FK V F+ + G LL Sbjct: 39 HNSVTHISFNPQHPHDFAVTSSTRVQIFSSRTRQVIKTFSRFKDVVYSASFR-SDGKLLC 97 Query: 279 AISKDKSCRVFDIRYSMKELMCVRDET-DYMTLEWHPINESMFTLACYDGSLKHFDLLQN 337 A V+D L+ + T ++H + + A D + +D+ Sbjct: 98 AGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFHTQDNKILATASDDRVTRLWDISNA 157 Query: 338 LNEPILTIPYAHDKCITSLSYNPV-GHIFATAAKDRTIRFWTR----ARPIDPNAYDDPT 392 + + +LS+ P H+ AT + D IR + + PI +D P Sbjct: 158 YEPQLELT--GATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTRSSGSTPIYSLNHDQPV 215 Query: 393 YN 394 N Sbjct: 216 EN 217 Score = 57.8 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 22/142 (15%), Positives = 46/142 (32%), Gaps = 6/142 (4%) Query: 244 KLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRD 303 + W + + ++K ++V F P + S ++F R + + + Sbjct: 25 RYWRQYTS---AQLVKEHNSVTHISFNPQHPHDFAVTSS-TRVQIFSSR-TRQVIKTFSR 79 Query: 304 ETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGH 363 D + + + G + +D + H +T + Sbjct: 80 FKDVVYSASFRSDGKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKF-HTQDNK 138 Query: 364 IFATAAKDRTIRFWTRARPIDP 385 I ATA+ DR R W + +P Sbjct: 139 ILATASDDRVTRLWDISNAYEP 160 >1NR0-A nrPDB Length = 611 Score = 138 bits (347), Expect = 6e-33, Method: Composition-based stats. Identities = 59/376 (15%), Positives = 127/376 (33%), Gaps = 30/376 (7%) Query: 96 IPAIQWTPEGR-RLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGD 154 + ++ + P R++ + +++ F F++ H V +++Y+ D S Sbjct: 150 MNSVDFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTG 209 Query: 155 ADGMIKIWQPNFSMVKEIDA-------AHTESIRDMAFSSNDSKFVTCSDDNILKIWNFS 207 DG I ++ + AH+ S+ + +S + +K + S D +KIWN + Sbjct: 210 GDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVA 269 Query: 208 NGKQERVLSGHHWDVKSCDWHPEMGLI------ASASKDNLVKLWDPRSGNCISSILKFK 261 K E+ + V + ++G+I S S + + +P G+ Sbjct: 270 TLKVEKTI-----PVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHN 324 Query: 262 HTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFT 321 + G L + + +DI + + +T +FT Sbjct: 325 KAITALS-SSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFT 383 Query: 322 LACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRAR 381 + +D LK + + + L+ + G I A + I ++ + Sbjct: 384 V-SWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACY-KHIAIYSHGK 441 Query: 382 PIDPNAYDDPTYNNKKINGWFFGINNDINAVREKSEFGAAPPP------PATLEPHALPN 435 + + + + F + + V GA+ PA + A N Sbjct: 442 LTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSN 501 Query: 436 MNGFI--NKKPRQEIP 449 F+ + R+ IP Sbjct: 502 NGAFLVATDQSRKVIP 517 Score = 126 bits (315), Expect = 3e-29, Method: Composition-based stats. Identities = 47/309 (15%), Positives = 102/309 (33%), Gaps = 18/309 (5%) Query: 89 SNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFT--FETLMQAHDSAVTTMKYSHD 146 + H + +P G G +W+ + T +T + V + + + Sbjct: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSE 114 Query: 147 SDWMISGDADGMIK---IWQPNFSMVKEIDAAHTESIRDMAFSSNDS-KFVTCSDDNILK 202 S + + G + ++ + ++ + F + + ++ SDDN + Sbjct: 115 SKRIAAVGE-GRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVA 173 Query: 203 IWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSIL---- 258 I+ K + H V S ++P+ L AS D + L++ G Sbjct: 174 IFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSL 233 Query: 259 ---KFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPI 315 +V + P G + + S DK+ +++++ E Sbjct: 234 KNVAHSGSVFGLTWSP-DGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIW 292 Query: 316 NESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIR 375 + +G + + + + Y H+K IT+LS + G +A + I Sbjct: 293 TKQALVSISANGFINFVNPELGSIDQVR---YGHNKAITALSSSADGKTLFSADAEGHIN 349 Query: 376 FWTRARPID 384 W + I Sbjct: 350 SWDISTGIS 358 Score = 121 bits (303), Expect = 7e-28, Method: Composition-based stats. Identities = 49/411 (11%), Positives = 115/411 (27%), Gaps = 95/411 (23%) Query: 66 MPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSF 125 + + + P + + + ++++ P+G G L+N Sbjct: 163 IISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDG 222 Query: 126 TFETLMQ-------AHDSAVTTMKYSHDSDWMISGDADGMIKIWQ--------------- 163 T + + AH +V + +S D + S AD IKIW Sbjct: 223 TKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTR 282 Query: 164 ----------------------------PNFSMVKEIDAAHTESIRDMAFSSNDSKFVTC 195 P + ++ H ++I ++ S++ + Sbjct: 283 IEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSA 342 Query: 196 SDDNILKIWNFSNGKQERVL------------SGHHWDVKSCDWHPEMGLIASASK--DN 241 + + W+ S G RV + D+ + W + ++ + D+ Sbjct: 343 DAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDS 402 Query: 242 LVKLWDPRSGNCISSILKFKHTV-------------------------LKTRFQPTKGNL 276 + + S + + + Sbjct: 403 SKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQF 462 Query: 277 LMAISKDKSCRVFDIR-YSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKH--FD 333 + +D V+ + S+ E+ + + ++ + + D S K + Sbjct: 463 VAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVAT---DQSRKVIPYS 519 Query: 334 LLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPID 384 + N H + +S++P AT + D ++ W +P D Sbjct: 520 VANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSD 570 Score = 84.4 bits (207), Expect = 1e-16, Method: Composition-based stats. Identities = 36/217 (16%), Positives = 84/217 (38%), Gaps = 14/217 (6%) Query: 82 SKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTM 141 + +NK+ + + +G V A Y ++++ T + + Sbjct: 400 VDSSKAVANKLSSQPLGLAVSADGDIAVAACYKH-IAIYSHGKLTEVPISYNSS----CV 454 Query: 142 KYSHDSDWMISGDADGMIKIWQPNFSMVKEIDA-AHTESIRDMAFSSNDSKFVTCSDDNI 200 S+D ++ G D + +++ + + V E+ H I +AFS+N + V Sbjct: 455 ALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRK 514 Query: 201 LKIWNFSNG---KQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSI 257 + ++ +N + H V W P+ +A+ S DN V +W+ + I Sbjct: 515 VIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPII 574 Query: 258 LKFKH---TVLKTRFQPTKGNLLMAISKDKSCRVFDI 291 +K H +V + +++ +D + + +++ Sbjct: 575 IKGAHAMSSVNSVIWL--NETTIVSAGQDSNIKFWNV 609 Score = 53.2 bits (126), Expect = 3e-07, Method: Composition-based stats. Identities = 18/82 (21%), Positives = 34/82 (41%), Gaps = 4/82 (4%) Query: 88 SSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNA--SSFTFETLMQAH-DSAVTTMKYS 144 S + + W+P+ RL + +WN S + AH S+V ++ + Sbjct: 531 SWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWL 590 Query: 145 HDSDWMISGDADGMIKIWQPNF 166 +++ ++S D IK W F Sbjct: 591 NETT-IVSAGQDSNIKFWNVPF 611 >3ODT-A nrPDB Length = 313 Score = 137 bits (346), Expect = 6e-33, Method: Composition-based stats. Identities = 42/197 (21%), Positives = 81/197 (41%), Gaps = 8/197 (4%) Query: 94 HVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKY-SHDSDWMIS 152 H + + ++ ++ +W + +QAH+++V K S + ++ Sbjct: 103 HQGNVCSLSFQDGVVISGSWDKTAKVWKE--GSLVYNLQAHNASVWDAKVVSFSENKFLT 160 Query: 153 GDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQE 212 AD IK+WQ N ++K H + +R +A +D F++CS+D ++K+ + G Sbjct: 161 ASADKTIKLWQ-NDKVIKTFSGIHNDVVRHLAVV-DDGHFISCSNDGLIKLVDMHTGDVL 218 Query: 213 RVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPT 272 R GH V P I S +D V++W +G+ I ++ Sbjct: 219 RTYEGHESFVYCIKLLPNGD-IVSCGEDRTVRIWSKENGSLKQVITLPAISIWSVDCMSN 277 Query: 273 KGNLLMAISKDKSCRVF 289 ++ S D R+F Sbjct: 278 GD--IIVGSSDNLVRIF 292 Score = 132 bits (331), Expect = 4e-31, Method: Composition-based stats. Identities = 42/276 (15%), Positives = 92/276 (33%), Gaps = 19/276 (6%) Query: 108 LVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIK---IWQP 164 + + G LW+ T++ + ++ Y + + ++ G D MI ++ Sbjct: 32 VASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYDSEKELLLFGGKDTMINGVPLFAT 91 Query: 165 NFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKS 224 + H ++ ++F D ++ S D K+W G L H+ V Sbjct: 92 SGEDPLYTLIGHQGNVCSLSF--QDGVVISGSWDKTAKVW--KEGSLVYNLQAHNASVWD 147 Query: 225 CDW-HPEMGLIASASKDNLVKLWDPRSGNCISSILK-FKHTVLKTRFQPTKGNLLMAISK 282 +AS D +KLW ++ I + V ++ S Sbjct: 148 AKVVSFSENKFLTASADKTIKLW--QNDKVIKTFSGIHNDVVRHLAVV--DDGHFISCSN 203 Query: 283 DKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPI 342 D ++ D+ E+ ++ P + D +++ + + + Sbjct: 204 DGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGD--IVSCGEDRTVRIWSKENGSLKQV 261 Query: 343 LTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWT 378 +T+P I S+ G I + D +R ++ Sbjct: 262 ITLPAI---SIWSVDCMSNGDIIV-GSSDNLVRIFS 293 Score = 129 bits (323), Expect = 3e-30, Method: Composition-based stats. Identities = 45/257 (17%), Positives = 96/257 (37%), Gaps = 15/257 (5%) Query: 126 TFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAF 185 ++ HD V + DS + S DG +++W + + + + + + Sbjct: 9 QLSATLKGHDQDVRDVVAVDDSK-VASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCY 67 Query: 186 SSNDSKFVTCSDD---NILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNL 242 S + D N + ++ S L GH +V S + + G++ S S D Sbjct: 68 DSEKELLLFGGKDTMINGVPLFATSGEDPLYTLIGHQGNVCSLSF--QDGVVISGSWDKT 125 Query: 243 VKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVR 302 K+W + G+ + ++ +V + N + S DK+ +++ + Sbjct: 126 AKVW--KEGSLVYNLQAHNASVWDAKVVSFSENKFLTASADKTIKLW--QNDKVIKTFSG 181 Query: 303 DETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVG 362 D + +++ F DG +K D+ +L H+ + + P G Sbjct: 182 IHNDVVR-HLAVVDDGHFISCSNDGLIKLVDMHTGD---VLRTYEGHESFVYCIKLLPNG 237 Query: 363 HIFATAAKDRTIRFWTR 379 + +DRT+R W++ Sbjct: 238 D-IVSCGEDRTVRIWSK 253 Score = 128 bits (322), Expect = 4e-30, Method: Composition-based stats. Identities = 47/279 (16%), Positives = 106/279 (37%), Gaps = 16/279 (5%) Query: 66 MPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFS---LWNA 122 + + G R+ + ++ + + ++ + E L+ + L+ Sbjct: 32 VASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYDSEKELLLFGGKDTMINGVPLFAT 91 Query: 123 SSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRD 182 S + H V ++ + D +ISG D K+W+ + AH S+ D Sbjct: 92 SGEDPLYTLIGHQGNVCSLSF-QDG-VVISGSWDKTAKVWKE--GSLVYNLQAHNASVWD 147 Query: 183 MAF-SSNDSKFVTCSDDNILKIWNFSNGKQERVLSG-HHWDVKSCDWHPEMGLIASASKD 240 S +++KF+T S D +K+W N K + SG H+ V+ + S S D Sbjct: 148 AKVVSFSENKFLTASADKTIKLW--QNDKVIKTFSGIHNDVVRHLAVVDDGH-FISCSND 204 Query: 241 NLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMC 300 L+KL D +G+ + + + V + P +++ +D++ R++ + + Sbjct: 205 GLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGD--IVSCGEDRTVRIWSKENGSLKQVI 262 Query: 301 VRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLN 339 ++ ++ + D ++ F ++ Sbjct: 263 TLPAISIWSV--DCMSNGDIIVGSSDNLVRIFSQEKSRW 299 Score = 71.7 bits (174), Expect = 6e-13, Method: Composition-based stats. Identities = 30/184 (16%), Positives = 65/184 (35%), Gaps = 16/184 (8%) Query: 210 KQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRF 269 + L GH DV+ + +AS S+D V+LW + + + + + Sbjct: 9 QLSATLKGHDQDVRDVVAV-DDSKVASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCY 67 Query: 270 QPTKGNLLMAI--SKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDG 327 K LL + +F + + + +L + + + +D Sbjct: 68 DSEKELLLFGGKDTMINGVPLFATSGEDPLYTLIGHQGNVCSLSF---QDGVVISGSWDK 124 Query: 328 SLKHFDLLQNLNEPILTIPYAHDKCITS---LSYNPVGHIFATAAKDRTIRFWTRARPID 384 + K + ++ AH+ + +S++ F TA+ D+TI+ W + I Sbjct: 125 TAKVW-----KEGSLVYNLQAHNASVWDAKVVSFSEN--KFLTASADKTIKLWQNDKVIK 177 Query: 385 PNAY 388 + Sbjct: 178 TFSG 181 Score = 61.7 bits (148), Expect = 6e-10, Method: Composition-based stats. Identities = 25/170 (14%), Positives = 58/170 (34%), Gaps = 7/170 (4%) Query: 247 DPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETD 306 DP +G +S+ LK H + + ++S+D + R++ + + Sbjct: 3 DPFTGYQLSATLK-GHDQDVRDVVAVDDSKVASVSRDGTVRLWSKDDQWLGTVVYTGQGF 61 Query: 307 YMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFA 366 ++ + E + D + L E L H + SLS+ G + Sbjct: 62 LNSVCYDSEKE-LLLFGGKDTMINGVPLFATSGEDPLYTLIGHQGNVCSLSF-QDG-VVI 118 Query: 367 TAAKDRTIRFWTRARPIDPNAYDDPTYNNKK---INGWFFGINNDINAVR 413 + + D+T + W + + + + K + F + ++ Sbjct: 119 SGSWDKTAKVWKEGSLVYNLQAHNASVWDAKVVSFSENKFLTASADKTIK 168 >5OQL-L nrPDB Length = 557 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 47/229 (20%), Positives = 85/229 (37%), Gaps = 16/229 (6%) Query: 158 MIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQ---ERV 214 I+ +P ++ + AH IR + V D +++++ G + + Sbjct: 85 SIRKREPLKTIGRFDSEAHCGEIR-----PDGRVLVAGEDTGRMQVFDVGQGTRAVILKT 139 Query: 215 LSGHHWDVKSCDWHP-EMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQP-- 271 H V W P E+ + S S D V+LWD S + V F P Sbjct: 140 WHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGS 199 Query: 272 TKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKH 331 NLL++ S D++ RV+D R +M + + P ++ + ++ Sbjct: 200 ANSNLLVSGSYDETVRVWDARAPGGAVMTFKHADPIEDVLPLPSGTTLLAASG--NAISV 257 Query: 332 FDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRA 380 DL+ L + H K +TSLS G + + D ++ + Sbjct: 258 LDLVAAKP---LRLITNHQKTVTSLSLASQGRRVVSGSLDGHVKVFETT 303 Score = 132 bits (332), Expect = 3e-31, Method: Composition-based stats. Identities = 44/284 (15%), Positives = 95/284 (33%), Gaps = 19/284 (6%) Query: 97 PAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDAD 156 ++ + L T +++ + DS + D +++G+ Sbjct: 61 SSLVAAAKTNDLFAVTAGPRVEIFSIRKREPLKTIGRFDSEAHCGEIRPDGRVLVAGEDT 120 Query: 157 GMIKIWQPNFSM---VKEIDAAHTESIRDMAFSSND-SKFVTCSDDNILKIWNFSNGKQE 212 G ++++ + + H + + +S + + ++CSDD +++W+ + Sbjct: 121 GRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPT 180 Query: 213 RVLSGHHWDVKSCDWHP---EMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRF 269 R+ +GH V+ + P L+ S S D V++WD R+ K + Sbjct: 181 RLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVMTFKHADPIEDVLP 240 Query: 270 QPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSL 329 P+ LL A + V D+ + + + +L DG + Sbjct: 241 LPSGTTLLAASG--NAISVLDLVAAKPLRLITNHQKTVTSLSLASQG-RRVVSGSLDGHV 297 Query: 330 KHFDLLQNLNEPILTIPYAHDKCITSLSY-----NPVGHIFATA 368 K F+ + + I SLS + A Sbjct: 298 KVFE----TTSWNVVAGAKYPSPILSLSVITAGASHDDRHLAVG 337 Score = 113 bits (282), Expect = 2e-25, Method: Composition-based stats. Identities = 42/227 (18%), Positives = 84/227 (37%), Gaps = 17/227 (7%) Query: 65 IMPPNAYRGRDRVINLPSKFTHLSSNKVKH----VIPAIQWTPEG-RRLVVATYSGEFSL 119 ++ GR +V ++ + T K H + +W+P L+ + L Sbjct: 113 VLVAGEDTGRMQVFDV-GQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRL 171 Query: 120 WNASSFTFETLMQAHDSAVTTMKY---SHDSDWMISGDADGMIKIWQPNFSMVKEIDAAH 176 W+ S L H V + S +S+ ++SG D +++W + H Sbjct: 172 WDLPSNDPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVMTFKH 231 Query: 177 TESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIAS 236 + I D+ + + + S N + + + K R+++ H V S + + S Sbjct: 232 ADPIEDVLPLPSGTTLLAAS-GNAISVLDLVAAKPLRLITNHQKTVTSLSLASQGRRVVS 290 Query: 237 ASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKD 283 S D VK+++ S N ++ K+ +L + S D Sbjct: 291 GSLDGHVKVFETTSWNVVAG-AKYPSPILSLSV------ITAGASHD 330 Score = 85.2 bits (209), Expect = 5e-17, Method: Composition-based stats. Identities = 27/198 (13%), Positives = 63/198 (31%), Gaps = 10/198 (5%) Query: 46 RRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTP-- 103 H P V + + +M + R+ +LPS + + P Sbjct: 141 HIHKQPVWVTKWSPTELTTLMSCSD-DKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPGS 199 Query: 104 -EGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIW 162 LV +Y +W+A + + H + + +++ + I + Sbjct: 200 ANSNLLVSGSYDETVRVWDARAPGGAVMTFKHADPIEDVLPLPSGTTLLAASGNA-ISVL 258 Query: 163 QPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKI-----WNFSNGKQERVLSG 217 + + H +++ ++ +S + V+ S D +K+ WN G + Sbjct: 259 DLVAAKPLRLITNHQKTVTSLSLASQGRRVVSGSLDGHVKVFETTSWNVVAGAKYPSPIL 318 Query: 218 HHWDVKSCDWHPEMGLIA 235 + + H + L Sbjct: 319 SLSVITAGASHDDRHLAV 336 Score = 77.9 bits (190), Expect = 9e-15, Method: Composition-based stats. Identities = 25/154 (16%), Positives = 57/154 (37%), Gaps = 12/154 (7%) Query: 235 ASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYS 294 +A V+++ R + +I +F +P G +L+A +VFD+ Sbjct: 75 VTAG--PRVEIFSIRKREPLKTIGRFDSEAHCGEIRP-DGRVLVAGEDTGRMQVFDVGQG 131 Query: 295 MKELMCVR---DETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDK 351 + ++ + +W P + D +++ +DL N + T H Sbjct: 132 TRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPTRLFT---GHTD 188 Query: 352 CITSLSY---NPVGHIFATAAKDRTIRFWTRARP 382 + ++ + ++ + + D T+R W P Sbjct: 189 YVRCGAFMPGSANSNLLVSGSYDETVRVWDARAP 222 >4BZK-B nrPDB Length = 297 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 53/239 (22%), Positives = 86/239 (35%), Gaps = 25/239 (10%) Query: 172 IDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNF--SNGKQERVLSGHHWDVKSCDW-H 228 I AH E I D + TCS D +KI+ K L+GH V DW H Sbjct: 4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAH 63 Query: 229 PEMGLI-ASASKDNLVKLWDPRSGNCISSILK--FKHTVLKTRFQPTK-GNLLMAISKDK 284 P+ G I AS S D V +W +G + +V ++ P + G LL+ S D Sbjct: 64 PKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 Query: 285 SCRVFDIRYSMK--ELMCVRDETDYMTLEWHP------------INESMFTLACYDGSLK 330 V + + + ++ + W P F D +K Sbjct: 124 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 Query: 331 HFDLLQNLNEPIL-TIPYAHDKCITSLSYNPV---GHIFATAAKDRTIRFWTRARPIDP 385 + + +L + H + ++++P A+ ++DRT WT+ P Sbjct: 184 IWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGP 242 Score = 132 bits (331), Expect = 4e-31, Method: Composition-based stats. Identities = 47/292 (16%), Positives = 99/292 (33%), Gaps = 35/292 (11%) Query: 92 VKHVIPAIQWTPEGRRLVVATYSGEFSLWNAS--SFTFETLMQAHDSAVTTMKYSHD--S 147 +I G+RL + ++ + + H+ V + ++H Sbjct: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG 67 Query: 148 DWMISGDADGMIKIWQPNFSMVKEIDAA--HTESIRDMAFSSN--DSKFVTCSDDNILKI 203 + S DG + IW+ +I H+ S+ + ++ + + S D + + Sbjct: 68 TILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 127 Query: 204 WNFSNGKQER--VLSGHHWDVKSCDWHP-------------EMGLIASASKDNLVKLW-- 246 F ++ H V S W P E + DNLVK+W Sbjct: 128 VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 187 Query: 247 --DPRSGNCISSILKFKHTVLKTRFQPT--KGNLLMAISKDKSCRVF----DIRYSMKEL 298 D ++ S++ V + PT + L ++S+D++C ++ + K L Sbjct: 188 NSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTL 247 Query: 299 MCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHD 350 + D + ++ ++ L+ D + + +NL H Sbjct: 248 LKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW--KENLEGKWEPAGEVHQ 297 Score = 114 bits (285), Expect = 9e-26, Method: Composition-based stats. Identities = 45/276 (16%), Positives = 87/276 (31%), Gaps = 30/276 (10%) Query: 133 AHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVK--EIDAAHTESIRDMAF--SSN 188 AH+ + + + + +D IKI++ K + H + + + Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 189 DSKFVTCSDDNILKIWNFSNG--KQERVLSGHHWDVKSCDWHPE--MGLIASASKDNLVK 244 + +CS D + IW NG Q V + H V S W P L+ AS D V Sbjct: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 Query: 245 LWDPRSGNCIS--SILKFKHTVLKTRFQP------------TKGNLLMAISKDKSCRVFD 290 + + + S I V + P + + D +++ Sbjct: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 Query: 291 IRYSMKEL---MCVRDETDYMT-LEWHPIN--ESMFTLACYDGSLKHF--DLLQNLNEPI 342 + + +D++ + W P S D + + D Q + Sbjct: 187 YNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKT 246 Query: 343 LTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWT 378 L + S++ G++ A + D + W Sbjct: 247 LLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWK 282 Score = 90.6 bits (223), Expect = 1e-18, Method: Composition-based stats. Identities = 29/190 (15%), Positives = 62/190 (32%), Gaps = 20/190 (10%) Query: 216 SGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPR--SGNCISSILKFKHTVLKTRF-QPT 272 + H+ + +A+ S D +K+++ + I ++ + V + + P Sbjct: 6 NAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 Query: 273 KGNLLMAISKDKSCRVFDIRYSMKELMCVR--DETDYMTLEWHPIN-ESMFTLACYDGSL 329 G +L + S D ++ + V +++W P + +A DG + Sbjct: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125 Query: 330 KHFDLLQNLNEPILTIPYAHDKCITSLSYNP-------------VGHIFATAAKDRTIRF 376 + +N + I AH + S S+ P F T D ++ Sbjct: 126 SVVEFKENGTTSPI-IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 184 Query: 377 WTRARPIDPN 386 W Sbjct: 185 WKYNSDAQTY 194 Score = 73.6 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 29/239 (12%), Positives = 69/239 (28%), Gaps = 41/239 (17%) Query: 1 MDGHNQNQYQNQN--------QIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPN 52 + GH ++ S + + + I ++ + + Sbjct: 49 LTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENG----RWSQIAVHAVHSASVNS 104 Query: 53 LVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHV--IPAIQWTP------- 103 + P ++ + G+ V+ T H + + W P Sbjct: 105 VQWAPH--EYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDG 162 Query: 104 ------EGRRLVVATYSGEFSLW----NASSFTFETLMQAHDSAVTTMKYSHD---SDWM 150 E R+ V +W +A ++ E+ ++ H V + +S ++ Sbjct: 163 EHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYL 222 Query: 151 ISGDADGMIKIWQPNFSM---VKEIDAAHT--ESIRDMAFSSNDSKFVTCSDDNILKIW 204 S D IW + K + + + ++S + + DN + +W Sbjct: 223 ASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 46.3 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 14/111 (12%), Positives = 32/111 (28%), Gaps = 13/111 (11%) Query: 65 IMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPE---GRRLVVATYSGEFSLW- 120 ++ Y + L S + + W+P L + +W Sbjct: 181 LVKIWKYNSDAQTYVLESTLE-----GHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWT 235 Query: 121 --NASSFTFETLMQAHDSA--VTTMKYSHDSDWMISGDADGMIKIWQPNFS 167 N +TL++ + +S + + D + +W+ N Sbjct: 236 QDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLE 286 Score = 37.0 bits (84), Expect = 0.018, Method: Composition-based stats. Identities = 14/67 (20%), Positives = 23/67 (34%), Gaps = 4/67 (5%) Query: 343 LTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARP----IDPNAYDDPTYNNKKI 398 + I AH++ I + G AT + D+TI+ + ID + Sbjct: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 Query: 399 NGWFFGI 405 FG Sbjct: 62 AHPKFGT 68 >4XYI-A nrPDB Length = 430 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 54/303 (17%), Positives = 109/303 (35%), Gaps = 39/303 (12%) Query: 134 HDSAVTTMKYSHDS-DWMISGDADGMIKIWQPNFSMVKEI--------DAAHTESIRDMA 184 H+ V ++ + D + + +G I+ N + I HT + Sbjct: 130 HEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGLG 189 Query: 185 FSS-NDSKFVTCSDDNILKIWNFSNGK----------QERVLSGHHWDVKSCDWH-PEMG 232 ++ + T ++D + +W+ V H V +H Sbjct: 190 WNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEA 249 Query: 233 LIASASKDNLVKLWDPR---SGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVF 289 L+ S S D +++ D R S + + + V F P LL S D + ++ Sbjct: 250 LLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALW 309 Query: 290 DIRYSMKELMCVRDETDYM-TLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILT---- 344 D+R + L + D + ++W P +E + + D + +DL + E + Sbjct: 310 DLRRLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSED 369 Query: 345 -------IPYAHDKCITSLSYNPVGHI-FATAAKDRTIRFWTRARPIDPNAYDDPTYNNK 396 + H ++ LS+NP A+ A D ++ W+ ++ I A D ++K Sbjct: 370 GAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWSPSKVI--WASDSLKIDSK 427 Query: 397 KIN 399 + Sbjct: 428 DLE 430 Score = 112 bits (280), Expect = 3e-25, Method: Composition-based stats. Identities = 36/213 (16%), Positives = 81/213 (38%), Gaps = 31/213 (14%) Query: 108 LVVATYSGEFSLWNA--SSFTFETLMQA--------HDSAVTTMKYSHDSDWMISG-DAD 156 L T +W+ S + E + H + V +++ + +++ D Sbjct: 198 LATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEALLTSVSDD 257 Query: 157 GMIKIWQ---PNFSMVKEIDAAHTESIRDMAFSS-NDSKFVTCSDDNILKIWNFSN-GKQ 211 ++I P+ S + AH + + +AF+ ND T S D+ + +W+ ++ Sbjct: 258 CTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLNQR 317 Query: 212 ERVLSGHHWDVKSCDWHP-EMGLIASASKDNLVKLWDPRSGNCISSIL------------ 258 L GH +V + W P + ++ ++S D V +WD ++ Sbjct: 318 LHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFM 377 Query: 259 --KFKHTVLKTRFQPTKGNLLMAISKDKSCRVF 289 + V + P +L +++ D +++ Sbjct: 378 HGGHTNRVSDLSWNPNNKWVLASLADDNILQIW 410 Score = 68.6 bits (166), Expect = 5e-12, Method: Composition-based stats. Identities = 25/174 (14%), Positives = 61/174 (35%), Gaps = 23/174 (13%) Query: 9 YQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPP 68 S L+ + T+ S +S + + + P Y + Sbjct: 246 QHEALLTSVSDDCTLQIHDTRLPSSSSASQCVK---AHEQPVNGVAFNPFNDYLL---AT 299 Query: 69 NAYRGRDRVINLPSKFTHLSSNK-VKHVIPAIQWTP-EGRRLVVATYSGEFSLWNASSFT 126 + + +L L + + + + +QW+P + LV ++ +W+ S Sbjct: 300 ASADHTVALWDLRRLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIG 359 Query: 127 FETLMQ--------------AHDSAVTTMKYSHDSDW-MISGDADGMIKIWQPN 165 E ++ H + V+ + ++ ++ W + S D +++IW P+ Sbjct: 360 EEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWSPS 413 Score = 57.4 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 29/166 (17%), Positives = 65/166 (39%), Gaps = 16/166 (9%) Query: 259 KFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELM-------CVRDETDY-MTL 310 + V K RF P +++ + + + +FD+ ++ + C+R T L Sbjct: 129 HHEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGL 188 Query: 311 EWHPINESMFTLACYDGSLKHFD-------LLQNLNEPILTIPYAHDKCITSLSYN-PVG 362 W+ I E D S+ +D L ++++ +++ + H + L ++ Sbjct: 189 GWNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHE 248 Query: 363 HIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFFGINND 408 + + + D T++ P +A + + +NG F ND Sbjct: 249 ALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFND 294 Score = 46.3 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 20/94 (21%), Positives = 32/94 (34%), Gaps = 8/94 (8%) Query: 293 YSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTI-----PY 347 Y + + + E D + P N + +G+ FDL +PI+ Sbjct: 120 YGLDIVQKIHHEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLR 179 Query: 348 AHDKCITSLSYN--PVGHIFATAAKDRTIRFWTR 379 H L +N G AT +D +I W Sbjct: 180 HHTSEGFGLGWNFIQEGT-LATGTEDTSICVWDI 212 >6CHG-A nrPDB Length = 312 Score = 136 bits (341), Expect = 3e-32, Method: Composition-based stats. Identities = 50/309 (16%), Positives = 122/309 (39%), Gaps = 30/309 (9%) Query: 81 PSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTT 140 +F + + Q +P+G + + + + ++ SS L H + Sbjct: 1 MLQFDKQVLPASGKISTSCQISPDGELIAIC-QNTDMLVYEISSSKMMKLTTTHKECINC 59 Query: 141 MKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNI 200 + +S DS + SG D ++I + ++ + HT + + +++ + + S D Sbjct: 60 LCWSPDSKCIASGSEDFTVEITHIIYGRIRRLM-GHTAPVISICYNNKGNILCSSSMDES 118 Query: 201 LKIWNFSNGKQERVLSGHHWDVKSCDW-HPEMGLIASASKDNLVKLWDPRSGNCISSILK 259 +K W+ +G + +S H V S D + +++S S D L++++D SG+C+ ++ Sbjct: 119 IKEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTY 178 Query: 260 FKHTVLKTRFQP-------TKGNLLMAISKDKSCRVFD-IRYSMKELMCVRDETDYMTLE 311 K + + P G L+ S D ++++ R ++ + L+ Sbjct: 179 DKDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLK 238 Query: 312 W-------HPINESMFTLACYD-GSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGH 363 + +P + ++ D GS+ +++ + + + I+ Sbjct: 239 YNCGLELIYPQGKDPLVISGNDSGSMCVWNVYSKNLVQKIDEKHRNSPLIS--------- 289 Query: 364 IFATAAKDR 372 +A+ D+ Sbjct: 290 --ISASYDK 296 Score = 130 bits (327), Expect = 1e-30, Method: Composition-based stats. Identities = 42/262 (16%), Positives = 99/262 (37%), Gaps = 20/262 (7%) Query: 89 SNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSD 148 + K I + W+P+ + + + + + LM H + V ++ Y++ + Sbjct: 50 TTTHKECINCLCWSPDSKCIASGSEDFTVEITHIIYGRIRRLM-GHTAPVISICYNNKGN 108 Query: 149 WMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSS-NDSKFVTCSDDNILKIWNFS 207 + S D IK W + +AH++++ + + S + S D +++I++ Sbjct: 109 ILCSSSMDESIKEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTE 168 Query: 208 NGKQERVLSGHHW--------DVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILK 259 +G + L+ + + + + S DN+VKLW+ G + + L Sbjct: 169 SGHCLKTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLW 228 Query: 260 -FKHTVLKTRFQ--------PTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTL 310 + T K ++ K L+++ + S V+++ YS + + ++ L Sbjct: 229 PHQETKAKLKYNCGLELIYPQGKDPLVISGNDSGSMCVWNV-YSKNLVQKIDEKHRNSPL 287 Query: 311 EWHPINESMFTLACYDGSLKHF 332 + +G F Sbjct: 288 ISISASYDKVATLSLNGECNLF 309 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 48/278 (17%), Positives = 104/278 (37%), Gaps = 27/278 (9%) Query: 139 TTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDD 198 T+ + S D + + + + +++ + S + ++ H E I + +S + + S+D Sbjct: 17 TSCQISPDGELIAIC-QNTDMLVYEISSSKMMKLTTTHKECINCLCWSPDSKCIASGSED 75 Query: 199 NILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSIL 258 ++I + G+ R L GH V S ++ + ++ S+S D +K W SG + ++ Sbjct: 76 FTVEITHIIYGR-IRRLMGHTAPVISICYNNKGNILCSSSMDESIKEWHVLSGTALKTMS 134 Query: 259 KFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDET--------DYMTL 310 V+ ++L + S D R+FD D+ T+ Sbjct: 135 AHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWIAEDGVVPISTV 194 Query: 311 EWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYN-------PVGH 363 ++ N + D +K ++ + + T + H + L YN P G Sbjct: 195 KFS-RNGKFLLVKSLDNVVKLWEYTRGT--VVRTFLWPHQETKAKLKYNCGLELIYPQGK 251 Query: 364 --IFATAAKDRTIRFW-----TRARPIDPNAYDDPTYN 394 + + ++ W + ID + P + Sbjct: 252 DPLVISGNDSGSMCVWNVYSKNLVQKIDEKHRNSPLIS 289 >4A11-B nrPDB Length = 408 Score = 135 bits (340), Expect = 3e-32, Method: Composition-based stats. Identities = 63/391 (16%), Positives = 129/391 (32%), Gaps = 53/391 (13%) Query: 55 VEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTP-EGRRLVVATY 113 + + D + RV+ L I + P EGR ++ Sbjct: 5 LSARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGS 64 Query: 114 SGEFSLWNASSFTFETLMQ-------------AHDSAVTTMKYSH-DSDWMISGDADGMI 159 G L++ + + ++ H +V T+++ D+ S D + Sbjct: 65 DGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTL 124 Query: 160 KIWQPN-------FSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQE 212 K+W N F+ + + + H + S+ + +++ + +G Sbjct: 125 KVWDTNTLQTADVFNFEETVYSHHMSPV-----STKHCLVAVGTRGPKVQLCDLKSGSCS 179 Query: 213 RVLSGHHWDVKSCDWHPEMGLI-ASASKDNLVKLWDPRSGN-CISSI------------- 257 +L GH ++ + W P I A+AS D+ VKLWD R + C+ ++ Sbjct: 180 HILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVES 239 Query: 258 --LKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVR----DETDYMTLE 311 V F + G L+ + D R+++ L+ + + Sbjct: 240 ANTAHNGKVNGLCFT-SDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFT 298 Query: 312 WHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKD 371 S F Y ++ + + +T+ H K + + + ++D Sbjct: 299 VSCGCSSEFVFVPYGSTIAVYTVYSG---EQITMLKGHYKTVDCCVFQSNFQELYSGSRD 355 Query: 372 RTIRFWTRARPIDPNAYDDPTYNNKKINGWF 402 I W + +P DD T ++N F Sbjct: 356 CNILAWVPSL-YEPVPDDDETTTKSQLNPAF 385 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 43/293 (14%), Positives = 102/293 (34%), Gaps = 37/293 (12%) Query: 160 KIWQPNFSMVKEIDAAHTESIRDMAFSS-NDSKFVTCSDDNILKIWNFSNGKQERVLSG- 217 ++ + ++++ H I + ++ D ++ +++ N ++ + Sbjct: 26 RVLGLELNKDRDVERIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCK 85 Query: 218 ------------HHWDVKSCDWHP-EMGLIASASKDNLVKLWDPRSGNCISSILKFKHTV 264 H + V++ W+P + G+ S+S D +K+WD + + + F+ TV Sbjct: 86 AVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQ-TADVFNFEETV 144 Query: 265 LKTRFQPTKGNLL--MAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTL 322 P ++ ++ D++ + + + + W P + + Sbjct: 145 YSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILAT 204 Query: 323 ACYDGSLKHFDLLQ-------------NLNEPILTIPYAHDKCITSLSYNPVGHIFATAA 369 A D +K +D+ + ++ + + AH+ + L + G T Sbjct: 205 ASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVG 264 Query: 370 KDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFFGINNDINAVREKSEFGAAP 422 D +R W + + NN K G F + + SEF P Sbjct: 265 TDNRMRLWNSSNGENTLVNYGKVCNNSK-KGLKFTV-----SCGCSSEFVFVP 311 Score = 119 bits (298), Expect = 3e-27, Method: Composition-based stats. Identities = 57/360 (15%), Positives = 127/360 (35%), Gaps = 48/360 (13%) Query: 10 QNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPET-SYTIDIMP- 67 + + + + Y D+ + YY + P+ Y+++ + Sbjct: 55 EGRYMLSGGSDGVIVLY-------DLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQW 107 Query: 68 ---------PNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEG---RRLVVATYSG 115 +++ +V + + T N + + + +P + V T Sbjct: 108 YPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTKHCLVAVGTRGP 166 Query: 116 EFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDW-MISGDADGMIKIWQP---------- 164 + L + S + ++Q H + + +S D+ + + AD +K+W Sbjct: 167 KVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITL 226 Query: 165 ------NFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSG- 217 V+ + AH + + F+S+ +T DN +++WN SNG+ V G Sbjct: 227 DQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGK 286 Query: 218 -HHWDVKSCDWHPEMGL---IASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTK 273 + K + G + + ++ SG I+ + TV FQ + Sbjct: 287 VCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQ-SN 345 Query: 274 GNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFD 333 L + S+D + + S+ E + DET + + +P E ++ + +G + Sbjct: 346 FQELYSGSRDCNILAWVP--SLYEPVPDDDETTTKS-QLNPAFEDAWSSSDEEGGTSAWS 402 >5WJC-A nrPDB Length = 430 Score = 135 bits (340), Expect = 3e-32, Method: Composition-based stats. Identities = 69/373 (18%), Positives = 125/373 (33%), Gaps = 54/373 (14%) Query: 50 LPNLVVEPETSYTIDIMPPNAYR-GRDRVINLPSKFTHLSSNKVKHVIPAIQ-WTPEGRR 107 LP+ P T Y+I + + G D+ + ++S ++ + +TP R Sbjct: 59 LPDKKTIPGTDYSIQRLILGTHTSGNDQ------NYLQIASVQLPNFDEDTTEFTPSTIR 112 Query: 108 LVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDS-DWMISGDADGMIKIWQPNF 166 AT S + S HD V +Y + + + G I+ Sbjct: 113 RAQATGSYTIEI----SQKIP-----HDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTC 163 Query: 167 SMVKEI--------DAAHTESIRDMAFSSN-DSKFVTCSDDNILKIWNFSNGKQERV--- 214 HT + ++ N T ++D ++ +W+ Sbjct: 164 HDALTTGEALPQAVLKGHTAEGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETK 223 Query: 215 -------LSGHHWDVKSCDWHPE-MGLIASASKDNLVKLWDPRSG---NCISSILKFKHT 263 H V +HP+ L+AS S D +++ D R I Sbjct: 224 VISPIAKYHRHTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKA 283 Query: 264 VLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYM-TLEWHPINESMFTL 322 + P LL S DK+ ++D+R + L + D + LEW P +E + Sbjct: 284 INAVAINPFNDYLLATASADKTVALWDLRNPYQRLHTLEGHEDEVYGLEWSPHDEPILAS 343 Query: 323 ACYDGSLKHFDLLQNLNEP-----------ILTIPYAHDKCITSLSYNPVGHIFA-TAAK 370 + D + +DL + E +L + H I+ S+ P + A Sbjct: 344 SSTDRRVCIWDLEKIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPNERWVVGSLAD 403 Query: 371 DRTIRFWTRARPI 383 D ++ W+ +R I Sbjct: 404 DNILQIWSPSRVI 416 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 34/194 (17%), Positives = 69/194 (35%), Gaps = 20/194 (10%) Query: 218 HHWDVKSCDWHPEM-GLIASASKDNLVKLWD------PRSGNCI--SSILKFKHTVLKTR 268 H DV + P+ +IA+ + ++D +G + + + Sbjct: 130 HDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLC 189 Query: 269 FQPTKGNLLMAISKDKSCRVFDIRYSMKELMCV----------RDETDYMTLEWHPINES 318 + P L ++D+ ++D++ R +++HP +E+ Sbjct: 190 WNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEA 249 Query: 319 MFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHI-FATAAKDRTIRFW 377 + D +L+ D N E + AH K I +++ NP ATA+ D+T+ W Sbjct: 250 LLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALW 309 Query: 378 TRARPIDPNAYDDP 391 P + Sbjct: 310 DLRNPYQRLHTLEG 323 >4U1E-I nrPDB Length = 347 Score = 135 bits (339), Expect = 4e-32, Method: Composition-based stats. Identities = 44/215 (20%), Positives = 80/215 (37%), Gaps = 19/215 (8%) Query: 173 DAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMG 232 H + + ++ +CS D+ +W NG++ L GH + S D Sbjct: 6 LTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCFTK 65 Query: 233 LIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLM----AISKDKSCRV 288 + S D +KLWD +G C+++ K V + F P L + S + Sbjct: 66 YCVTGSADYSIKLWDVSNGQCVAT-WKSPVPVKRVEFSPCGNYFLAILDNVMKNPGSINI 124 Query: 289 FDIR--YSMKELMCVRDET----------DYMTLEWHPINESMFTLACYDGSLKHFDLLQ 336 ++I + EL V +E D T+ DG + +D+ Sbjct: 125 YEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKYDVSN 184 Query: 337 NLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKD 371 N + H+K I+ + ++P F T+++D Sbjct: 185 NY--EYVDSIDLHEKSISDMQFSPDLTYFITSSRD 217 Score = 110 bits (275), Expect = 1e-24, Method: Composition-based stats. Identities = 43/319 (13%), Positives = 108/319 (33%), Gaps = 32/319 (10%) Query: 87 LSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHD 146 + + + +++ EG L + S+W + + + H + ++ Sbjct: 4 IKLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCF 63 Query: 147 SDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDD-----NIL 201 + + ++G AD IK+W + + ++ + FS + F+ D+ + Sbjct: 64 TKYCVTGSADYSIKLWDVSNGQCVATWKS-PVPVKRVEFSPCGNYFLAILDNVMKNPGSI 122 Query: 202 KIWNFS-----------NGKQERVLSGHHW-DVKSCD-WHPEMGLIASASKDNLVKLWDP 248 I+ + + + H D + W + I + KD + +D Sbjct: 123 NIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKYDV 182 Query: 249 RSG-NCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDY 307 + + SI + ++ +F P + S+D + + D+ +++ L + Sbjct: 183 SNNYEYVDSIDLHEKSISDMQFSP-DLTYFITSSRDTNSFLVDV-STLQVLKKYETDCPL 240 Query: 308 MTLEWHPINESMFTLA----------CYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLS 357 T P+ E + + + E + H + +++ Sbjct: 241 NTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEEEIGRVQGHFGPLNTVA 300 Query: 358 YNPVGHIFATAAKDRTIRF 376 +P G +A+ +D IR Sbjct: 301 ISPQGTSYASGGEDGFIRL 319 Score = 81.3 bits (199), Expect = 8e-16, Method: Composition-based stats. Identities = 29/202 (14%), Positives = 71/202 (35%), Gaps = 19/202 (9%) Query: 215 LSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKG 274 L+GH + ++ E L+ S SKD+ +W +G + ++ T+ Sbjct: 6 LTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVD-CFT 64 Query: 275 NLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLA----CYDGSLK 330 + S D S +++D+ + + + + +E+ P + GS+ Sbjct: 65 KYCVTGSADYSIKLWDV-SNGQCVATWKSPVPVKRVEFSPCGNYFLAILDNVMKNPGSIN 123 Query: 331 HFDLLQNLNEPILTIPYA--------HDK--CITSLSYNPVGHIFATAAKDRTIRFWTRA 380 +++ ++ LT H+ T ++ G KD I + + Sbjct: 124 IYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKYDVS 183 Query: 381 RP---IDPNAYDDPTYNNKKIN 399 +D + + ++ + + Sbjct: 184 NNYEYVDSIDLHEKSISDMQFS 205 Score = 68.2 bits (165), Expect = 7e-12, Method: Composition-based stats. Identities = 31/280 (11%), Positives = 86/280 (30%), Gaps = 43/280 (15%) Query: 1 MDGHNQNQYQ------NQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLV 54 +DGH + + + S +K + DVS+ + + + Sbjct: 48 LDGHTGTIWSIDVDCFTKYCVTGSADYSIKLW-------DVSNGQCVATWKSPVPVKRVE 100 Query: 55 VEPETSYTIDIM--------------PPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQ 100 P +Y + I+ + + +++ Sbjct: 101 FSPCGNYFLAILDNVMKNPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAG 160 Query: 101 WTPEGRRLVVATYSGEFSLWNASSF-TFETLMQAHDSAVTTMKYSHDSDWMISGDADGMI 159 W+ +G+ ++ G+ S ++ S+ + + H+ +++ M++S D + I+ D Sbjct: 161 WSTKGKYIIAGHKDGKISKYDVSNNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNS 220 Query: 160 KIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCS----DDNI----------LKIWN 205 + + V + + + + D + ++ Sbjct: 221 FLVDVSTLQVLKKYE-TDCPLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYH 279 Query: 206 FSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKL 245 ++ + GH + + P+ AS +D ++L Sbjct: 280 KIFEEEIGRVQGHFGPLNTVAISPQGTSYASGGEDGFIRL 319 Score = 53.6 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 16/87 (18%), Positives = 31/87 (35%), Gaps = 4/87 (4%) Query: 295 MKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCIT 354 MK + E ++++ + +F D S + +LN L H I Sbjct: 1 MKAIKLTGHERPLTQVKYNKEGDLLF-SCSKDSSASVW---YSLNGERLGTLDGHTGTIW 56 Query: 355 SLSYNPVGHIFATAAKDRTIRFWTRAR 381 S+ + T + D +I+ W + Sbjct: 57 SIDVDCFTKYCVTGSADYSIKLWDVSN 83 Score = 49.7 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 17/157 (10%), Positives = 53/157 (33%), Gaps = 16/157 (10%) Query: 66 MPPNAYRGRDRVINLPSKFTHLSSNK-VKHVIPAIQWTPEGRRLVVATYSGEFSLWNASS 124 + G+ ++ + + ++ S + I +Q++P+ + ++ L + S+ Sbjct: 168 IIAGHKDGKISKYDVSNNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLVDVST 227 Query: 125 FTFETLMQAHDSAVTTMKYSHDSDWMISGDA--------------DGMIKIWQPNFSMVK 170 + D + T + +++I G + + F Sbjct: 228 LQVLKKYET-DCPLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEEEI 286 Query: 171 EIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFS 207 H + +A S + + + +D +++ +F Sbjct: 287 GRVQGHFGPLNTVAISPQGTSYASGGEDGFIRLHHFE 323 >4PSX-B nrPDB Length = 401 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 55/288 (19%), Positives = 110/288 (38%), Gaps = 23/288 (7%) Query: 128 ETLMQAHDSAVTTMKYSH-DSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFS 186 T H+ +T +Y D + + + + G ++ + ++ H ++ ++FS Sbjct: 111 ITAKYEHEEEITRARYMPQDPNIVATINGQGTTFLYSRSEG-LQSTLKFHKDNGYALSFS 169 Query: 187 S-NDSKFVTCSDDNILKIWNFSNG----KQERVLSG-HHWDVKSCDWHP-EMGLIASASK 239 + + ++ SDD+ + +W +G K R + H + WH L + S+ Sbjct: 170 TLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSE 229 Query: 240 DNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELM 299 D+L+K+ D R+ N +K F NLL A D ++D+R + L Sbjct: 230 DSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLH 289 Query: 300 CVRDETD-YMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEP-----------ILTIPY 347 + D LE+ + + + D L +DL Q E ++ + Sbjct: 290 HMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHA 349 Query: 348 AHDKCITSLSYNPV-GHIFATAAKDRTIRFWTRARPIDPNAYDDPTYN 394 H + NP + A+A ++ ++ W + + P P N Sbjct: 350 GHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSL-PIVGGPPKVN 396 >3F3P-A nrPDB Length = 351 Score = 131 bits (329), Expect = 7e-31, Method: Composition-based stats. Identities = 65/290 (22%), Positives = 108/290 (37%), Gaps = 42/290 (14%) Query: 169 VKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIW----NFSNGKQERVLSGHHWDVKS 224 ++ D+ H + + D+ + TCS D +K++ + SN + H + + Sbjct: 3 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 62 Query: 225 CDW-HPE-MGLIASASKDNLVKLW--DPRSGNC-------ISSILKFKHTVLKTRFQPTK 273 DW PE +IASAS D VKLW DP C + ++ K ++ +F P Sbjct: 63 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 122 Query: 274 GNLLMAI-SKDKSCRVFDI-------RYSMKELMCVRDETDYM------TLEWHPINESM 319 L +A D R++D +++ M V L W P S Sbjct: 123 LGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSP 182 Query: 320 FTLACYDGSLKHFDLLQNLNEPILTI---PYAHDKCITSLSYNP-VGHI---FATAAKDR 372 LA +L+ + Q + L + H I S+S+ P +G AT KD Sbjct: 183 EKLAVS--ALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDG 240 Query: 373 TIRFWTRARPIDPNAYDDPTYNNKKINGW----FFGINNDINAVREKSEF 418 IR + + P A ++ N+ + + EK+E Sbjct: 241 RIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAEL 290 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 51/335 (15%), Positives = 107/335 (31%), Gaps = 54/335 (16%) Query: 92 VKHVIPAIQWTPEGRRLVVATYSGEFSLW----NASSFTFETLMQAHDSAVTTMKYSHD- 146 ++ + + GR + + ++ + S++ +AHDS++ + ++ Sbjct: 10 HDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPE 69 Query: 147 -SDWMISGDADGMIKIWQPNFSMV---------KEIDAAHTESIRDMAFSSN--DSKFVT 194 + S D +K+W+ + S+ + F+ K Sbjct: 70 YGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLAC 129 Query: 195 CSDDNILKIWNFSNGKQERVLS-------------GHHWDVKSCDWHPE----MGLIASA 237 +D IL++++ R + H W P L SA Sbjct: 130 LGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSA 189 Query: 238 ---------SKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKG---NLLMAISKDKS 285 KD + + + + K + + P+ G L+ KD Sbjct: 190 LEQAIIYQRGKDGKLHV--------AAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGR 241 Query: 286 CRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTI 345 R+F I + L T+ + + + + +L NL +L+ Sbjct: 242 IRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSE 301 Query: 346 PYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRA 380 H+ + S+S+N G I ++A D +R W Sbjct: 302 HDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKAT 336 Score = 49.4 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 18/126 (14%), Positives = 43/126 (34%), Gaps = 4/126 (3%) Query: 46 RRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEG 105 + + ++ P ++ GR R+ + K + L+S + + + Sbjct: 213 HKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADV 272 Query: 106 RRLVVA-TYSGEFSLWNASSFTFETLMQAHDSA---VTTMKYSHDSDWMISGDADGMIKI 161 + S S L+ HD V ++ ++ + S DG +++ Sbjct: 273 DMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRL 332 Query: 162 WQPNFS 167 W+ +S Sbjct: 333 WKATYS 338 Score = 31.6 bits (70), Expect = 0.75, Method: Composition-based stats. Identities = 8/36 (22%), Positives = 13/36 (36%) Query: 91 KVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFT 126 + ++ W G L A G+ LW A+ Sbjct: 304 DHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSN 339 >6ELZ-p nrPDB Length = 460 Score = 130 bits (327), Expect = 1e-30, Method: Composition-based stats. Identities = 41/331 (12%), Positives = 101/331 (30%), Gaps = 39/331 (11%) Query: 85 THLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYS 144 ++L+S + + ++ + ++ +Y G W+ S + H + +KY Sbjct: 95 SYLNSFSNEDWVSSLDVGDGSKHIISGSYDGIVRTWDL-SGNVQKQYSGHSGPIRAVKYI 153 Query: 145 HDSDWMISGDADGMIKIW-----------------------QPNFSMVKEIDAAHTESIR 181 + ++S D +++W I H + Sbjct: 154 S-NTRLVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVV 212 Query: 182 DMAFSSNDSKFVTCSDDNILKIWN--FSNGKQERVLSGHHWDVKSCDWHPEMGLIASASK 239 + S ++S+ ++ S DN + W+ + L + + K Sbjct: 213 SIDVS-DNSRILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLT-MK 270 Query: 240 DNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELM 299 D ++ +S + V + F T + ++S+D + + +D+ + Sbjct: 271 DGTIR-----RRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDT 325 Query: 300 CVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPIL-TIPYAHDKCITSLSY 358 + + +N + + D + + H ++SL Sbjct: 326 RTTSYSLLSIAQLSTLN--LLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDT 383 Query: 359 NPVGHIF-ATAAKDRTIRFWTRARPIDPNAY 388 P + + D T++ W R P Sbjct: 384 CPENEYILCSGSHDGTVKVWDV-RSTSPMYT 413 Score = 112 bits (279), Expect = 5e-25, Method: Composition-based stats. Identities = 56/366 (15%), Positives = 111/366 (30%), Gaps = 80/366 (21%) Query: 40 INLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAI 99 + Y + V + + +Y G R +L S I A+ Sbjct: 92 LPPSYLNSFSNEDWVSSLDVGDGSKHIISGSYDGIVRTWDLSGNVQKQYSG-HSGPIRAV 150 Query: 100 QWTPEGRRLVVATYSGEFSLW-----------------------NASSFTFETLMQAHDS 136 ++ R LV A LW N +++ H + Sbjct: 151 KYISNTR-LVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKA 209 Query: 137 AVTTMKYSHDSDWMISGDADGMIKIW-----------------QPNFSM----------- 168 V ++ S D+ ++S D I W PN + Sbjct: 210 PVVSIDVS-DNSRILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLT 268 Query: 169 ----------VKEIDAAHTESIRDMAF-SSNDSKFVTCSDDNILKIWNFSNGKQERVLSG 217 + +HT + + F S++++ + S D+ +K W+ + + Sbjct: 269 MKDGTIRRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDTRTT 328 Query: 218 HHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCI----SSILKFKHTVLKTRFQPTK 273 + + S + L+A S + L DPR G ++ K+ V P Sbjct: 329 -SYSLLSIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPEN 387 Query: 274 GNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMT--------LEWHPINESMFTLACY 325 +L + S D + +V+D+R + R++ ++W + A Sbjct: 388 EYILCSGSHDGTVKVWDVRSTSPMYTITREDKSVQKGVNDKVFAVKWA--EKVGIISAGQ 445 Query: 326 DGSLKH 331 D ++ Sbjct: 446 DKKIQI 451 Score = 40.1 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 10/71 (14%), Positives = 22/71 (30%), Gaps = 3/71 (4%) Query: 341 PILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDP-NAYDDPTYNNKKI- 398 P ++++ ++SL + + D +R W + + + K Sbjct: 94 PSYLNSFSNEDWVSSLDVGDGSKHIISGSYDGIVRTWDLSGNVQKQYSGHSGPIRAVKYI 153 Query: 399 -NGWFFGINND 408 N ND Sbjct: 154 SNTRLVSAGND 164 >5MWJ-A nrPDB Length = 337 Score = 128 bits (322), Expect = 4e-30, Method: Composition-based stats. Identities = 47/306 (15%), Positives = 111/306 (36%), Gaps = 15/306 (4%) Query: 38 PYINLYYNRRHGLP--NLVVEPETSYTIDIMPPNAYRGRDRVINL-----PSKFTHLSSN 90 P I + + + L +V S + +G +V ++ S + L Sbjct: 36 PGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGG-KGCVKVWDISHPGNKSPVSQLDCL 94 Query: 91 KVKHVIPAIQWTPEGRRLVVATYSGEFSLWNA--SSFTFETLMQAHDSAVTTMKYSHDSD 148 + I + + P+G L+V + S+W+ + + + + A + S DS Sbjct: 95 NRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSK 154 Query: 149 WMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSN 208 S +DG I +W + + HT+ + S++ +K T DN ++ W+ Sbjct: 155 VCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLRE 214 Query: 209 GKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTR 268 G+Q + + S + P +A + + V++ + + + VL + Sbjct: 215 GRQLQQHDF-TSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQ-LHLHESCVLSLK 272 Query: 269 FQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGS 328 F G ++ KD + Y + ++ + ++ + +++ D Sbjct: 273 FA-YCGKWFVSTGKDNLLNAWRTPYGA-SIFQSKESSSVLSCDIS-VDDKYIVTGSGDKK 329 Query: 329 LKHFDL 334 +++ Sbjct: 330 ATVYEV 335 Score = 126 bits (316), Expect = 2e-29, Method: Composition-based stats. Identities = 47/308 (15%), Positives = 95/308 (30%), Gaps = 16/308 (5%) Query: 79 NLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASS-FTFETLMQAH--- 134 +P +++ V+ A+ + R + G +W+ S + Q Sbjct: 37 GIPRHARQINTLNHGEVVCAVTISNPTRHVYTGG-KGCVKVWDISHPGNKSPVSQLDCLN 95 Query: 135 -DSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTES--IRDMAFSSNDSK 191 D+ + + K D +I G + IW + + + +A S + Sbjct: 96 RDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKV 155 Query: 192 FVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSG 251 +C D + +W+ N R GH D + + + DN V+ WD R G Sbjct: 156 CFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREG 215 Query: 252 NCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLE 311 + F + + PT G L + + V + K E+ ++L+ Sbjct: 216 RQLQQHD-FTSQIFSLGYCPT-GEWLAVGMESSNVEVLHVNKPDK-YQLHLHESCVLSLK 272 Query: 312 WHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKD 371 + + F D L + + + S + T + D Sbjct: 273 FAYCGKW-FVSTGKDNLLNAWRTPYGAS----IFQSKESSSVLSCDISVDDKYIVTGSGD 327 Query: 372 RTIRFWTR 379 + + Sbjct: 328 KKATVYEV 335 Score = 110 bits (275), Expect = 1e-24, Method: Composition-based stats. Identities = 43/267 (16%), Positives = 92/267 (34%), Gaps = 15/267 (5%) Query: 134 HDSAVTTMKYSHDSDWMISGDADGMIKIWQ----PNFSMVKEIDAAHTE-SIRDMAFSSN 188 H V + S+ + + +G G +K+W N S V ++D + + IR + Sbjct: 50 HGEVVCAVTISNPTRHVYTGG-KGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPD 108 Query: 189 DSKFVTCSDDNILKIWNFS--NGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW 246 + + + L IW+ + + + L+ + P+ + S D + +W Sbjct: 109 GCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVW 168 Query: 247 DPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETD 306 D + + G L D + R +D+R ++L + Sbjct: 169 DLHNQTLVRQFQGHTDGASCIDIS-NDGTKLWTGGLDNTVRSWDLREG-RQLQQHDFTSQ 226 Query: 307 YMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFA 366 +L + P E + +++ + N+P + H+ C+ SL + G F Sbjct: 227 IFSLGYCPTGEW-LAVGMESSNVEVLHV----NKPDKYQLHLHESCVLSLKFAYCGKWFV 281 Query: 367 TAAKDRTIRFWTRARPIDPNAYDDPTY 393 + KD + W + + Sbjct: 282 STGKDNLLNAWRTPYGASIFQSKESSS 308 Score = 89.4 bits (220), Expect = 3e-18, Method: Composition-based stats. Identities = 34/194 (17%), Positives = 67/194 (34%), Gaps = 15/194 (7%) Query: 207 SNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPR---SGNCISSI--LKFK 261 + +Q L+ H V + + + K VK+WD + + +S + L Sbjct: 40 RHARQINTLN-HGEVVCAVTISNPTRHVYTGGK-GCVKVWDISHPGNKSPVSQLDCLNRD 97 Query: 262 HTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELM--CVRDETDYMTLEWHPINESM 319 + + + P G L+ + + ++D+ + L P ++ Sbjct: 98 NYIRSCKLLP-DGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVC 156 Query: 320 FTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTR 379 F C DG++ +DL N+ ++ H + + + G T D T+R W Sbjct: 157 F-SCCSDGNIAVWDL---HNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDL 212 Query: 380 ARPIDPNAYDDPTY 393 R D T Sbjct: 213 -REGRQLQQHDFTS 225 >1PI6-A nrPDB Length = 615 Score = 128 bits (321), Expect = 6e-30, Method: Composition-based stats. Identities = 60/313 (19%), Positives = 114/313 (36%), Gaps = 35/313 (11%) Query: 78 INLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYS----GEFSLWNASSFTFETLMQA 133 +N+ S+F L+ I I W EGRRL V G F W++ + E + Sbjct: 106 VNVKSEFQVLAGP-----ISDISWDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHS 160 Query: 134 HDSAVTTMKYSHDSDWMISGDADGMIKIWQ-PNFSMVKEIDAAHTES--IRDMAFSSNDS 190 +K S M GD DG + +Q P F H + +RD+ FS + Sbjct: 161 QRINACHLKQSRPMRSMTVGD-DGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSG 219 Query: 191 KFV-TCSDDNILKIWNFSNGKQERVLSGHHWDV----KSCDWHPEMGLIASASKDNLVKL 245 +FV T D + ++ +G+ + + V + W A+ D +++ Sbjct: 220 EFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQK-FATVGADATIRV 278 Query: 246 WDPRSGNCIS--SILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRD 303 WD + C+ ++ K + + T ++++S D + +++ + Sbjct: 279 WDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGH 338 Query: 304 ETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGH 363 L +P YDG + + ++ H I SL N Sbjct: 339 NKGITALTVNP-----LISGSYDGRIMEWSSS--------SMHQDHSNLIVSLD-NSKAQ 384 Query: 364 IFATAAKDRTIRF 376 +++ + D T++ Sbjct: 385 EYSSISWDDTLKV 397 Score = 112 bits (281), Expect = 3e-25, Method: Composition-based stats. Identities = 55/355 (15%), Positives = 122/355 (34%), Gaps = 34/355 (9%) Query: 93 KHVIPAIQWTP--EGRRLVVATYSGEFSLW----NASSFTFET----LMQAHDSAVTTMK 142 V+ ++++P + L SG+ +W + S + E Q ++ + Sbjct: 64 SSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDIS 123 Query: 143 YSHDSDWMISG--DADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDS-KFVTCSDDN 199 + + + D + + H++ I + + +T DD Sbjct: 124 WDFEGRRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDG 183 Query: 200 ILKIWNFSNGKQERVLSGHH---WDVKSCDWHPEMGLIA-SASKDNLVKLWDPRSGNCIS 255 + + K HH V+ ++ P+ G + D + +D +SG + Sbjct: 184 SVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLK 243 Query: 256 SILKFKHTVLKTRFQPT--KGNLLMAISKDKSCRVFDIRYSMK--ELMCVRDETDYMTLE 311 I + V F + + D + RV+D+ S + + + + Sbjct: 244 YIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVG 303 Query: 312 WHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKD 371 DG+L ++L ++ +L H+K IT+L+ NP + + D Sbjct: 304 VVATGNGRIISLSLDGTLNFYEL---GHDEVLKTISGHNKGITALTVNP----LISGSYD 356 Query: 372 RTIRFWTRARPIDPNAYDDPTYNNKKINGWFFGINNDINAVR----EKSEFGAAP 422 I W+ + ++ + +N K + + + ++ K EFG+ P Sbjct: 357 GRIMEWSSSSMHQDHSNLIVSLDNSK--AQEYSSISWDDTLKVNGITKHEFGSQP 409 Score = 79.0 bits (193), Expect = 4e-15, Method: Composition-based stats. Identities = 54/354 (15%), Positives = 112/354 (31%), Gaps = 58/354 (16%) Query: 71 YRGRDRVINLPSKFTHLSSNKVKHVI--PAIQWTPEGR-RLVVATYSGEFSLWNASSFTF 127 RV ++ + K + + G R++ + G + + Sbjct: 272 ADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEV 331 Query: 128 ETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSS 187 + H+ +T + + +ISG DG I W + + H+ I + +S Sbjct: 332 LKTISGHNKGITALTVNP----LISGSYDGRIMEWSSS-----SMHQDHSNLIVSLD-NS 381 Query: 188 NDSKFVTCSDDNILK---IWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIA---SASKDN 241 ++ + S D+ LK I G Q +V S ++ + + + LI + Sbjct: 382 KAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIK 441 Query: 242 LVKLWDPRSGNCIS------------SILKFKHTVLKTRFQ--------------PTKGN 275 V+L P S +S +I FK + L+ F Sbjct: 442 SVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSET 501 Query: 276 LLMAISKDKSCRVFDIRYSMKELMCVRDETD-YMTLEWHP---------INESMFTLACY 325 + A ++D++ + T + W P I E + Sbjct: 502 YIAAGDVMGKILLYDLQSREVKTSRWAFRTSKINAISWKPAEKGANEEEIEEDLVATGSL 561 Query: 326 DGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTR 379 D ++ + + + + I+ AH + +L + ++ D I+ W Sbjct: 562 DTNIFIYSVKRPMK--IIKALNAHKDGVNNLLW-ETPSTLVSSGADACIKRWNV 612 Score = 79.0 bits (193), Expect = 4e-15, Method: Composition-based stats. Identities = 36/265 (13%), Positives = 75/265 (28%), Gaps = 25/265 (9%) Query: 139 TTMKYSHDSDWMIS-GDADGMIKIWQPNFSMV---KEIDAAHTESIRDMAFSS--NDSKF 192 T + Y ++ + ++ S V + + + + FS Sbjct: 22 THLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYL 81 Query: 193 VTCSDDNILKIW--------NFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKD---- 240 + + + +W N + + W E + + Sbjct: 82 CSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNF 141 Query: 241 NLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFD---IRYSMKE 297 + WD SGN + + + + ++ M + D S + ++S + Sbjct: 142 GVFISWD--SGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASD 199 Query: 298 LMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQN-LNEPILTIPYAHDKCITSL 356 + + +E+ P + D + FD + I I +L Sbjct: 200 RTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFAL 259 Query: 357 SYNPVGHIFATAAKDRTIRFWTRAR 381 S+ FAT D TIR W Sbjct: 260 SWL-DSQKFATVGADATIRVWDVTT 283 >6J6H-n nrPDB Length = 455 Score = 127 bits (319), Expect = 1e-29, Method: Composition-based stats. Identities = 44/208 (21%), Positives = 81/208 (38%), Gaps = 9/208 (4%) Query: 210 KQERVLSGHHWDVKSCDWHPE-MGLIASASKDNLVKLWD-PRSGNCISSILKFKHTVLKT 267 K R GH + + P+ LI S D+ +K+WD C+ + Sbjct: 153 KVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKAL 212 Query: 268 RFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDG 327 RF + L + S D+S +++D + + T +E P N F + + Sbjct: 213 RFTEDCQSFL-SSSFDRSVKIWDTETGKVKTRLHLNSTP-ADVESRPTNPHEFIVGLSNS 270 Query: 328 SLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRA-----RP 382 + H+D + N+ ++ H I +L Y P G F ++++D+T+R W + Sbjct: 271 KILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQ 330 Query: 383 IDPNAYDDPTYNNKKINGWFFGINNDIN 410 I A + N + +F + N Sbjct: 331 ISDTAQHSMPFLNVHPSQNYFCAQSMDN 358 Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats. Identities = 49/272 (18%), Positives = 97/272 (35%), Gaps = 18/272 (6%) Query: 126 TFETLMQAHDSAVTTMKYSH-DSDWMISGDADGMIKIWQPNF-SMVKEIDAAHTESIRDM 183 H T +K+ ++SG D IKIW H + I+ + Sbjct: 153 KVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKAL 212 Query: 184 AFSSNDSKFVTCSDDNILKIWNFSNGKQERVLS--GHHWDVKSCDWHPEMGLIASASKDN 241 F+ + F++ S D +KIW+ GK + L DV+S +P ++ Sbjct: 213 RFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHE--FIVGLSNS 270 Query: 242 LVKLWDPRSGN---CISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKEL 298 + +D R + + ++L ++ P G+ ++ S+DK+ R+++ + ++ Sbjct: 271 KILHYDDRVSENQGLVQTYDHHLSSILALKYFP-DGSKFISSSEDKTVRIWENQINVPIK 329 Query: 299 MCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKC--ITSL 356 M +++ F D + F L I H SL Sbjct: 330 QISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISL 389 Query: 357 SYNPVGHIFATAAKDRTIRF----WTRARPID 384 +++ G + D R W +R ++ Sbjct: 390 AFSGDGRYICSG--DSKSRLFTWDWNTSRLLN 419 Score = 120 bits (301), Expect = 1e-27, Method: Composition-based stats. Identities = 43/299 (14%), Positives = 97/299 (32%), Gaps = 19/299 (6%) Query: 89 SNKVKHVIPAIQWTP-EGRRLVVATYSGEFSLWNASS-FTFETLMQAHDSAVTTMKYSHD 146 A+++ P G ++ +W+ + Q H+ + ++++ D Sbjct: 158 YPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTED 217 Query: 147 SDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWN- 205 +S D +KIW VK ++ + +N +F+ ++ + ++ Sbjct: 218 CQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDD 277 Query: 206 --FSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSG---NCISSILKF 260 N + H + + + P+ S+S+D V++W+ + IS + Sbjct: 278 RVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQH 337 Query: 261 KHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRY----SMKELMCVRDETDYMTLEWHPIN 316 L N A S D F ++ K++ Y + Sbjct: 338 SMPFLNVH---PSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGD 394 Query: 317 ESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNP--VGHIFATAAKDRT 373 L +D N + + I +K IT + ++P + + A + Sbjct: 395 GRYICSGDSKSRLFTWD--WNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKI 451 Score = 76.3 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 41/267 (15%), Positives = 90/267 (33%), Gaps = 33/267 (12%) Query: 1 MDGHNQN------QYQNQNQIQQSQQPPLKKYVTQRRSVDVSS--PYINLYYNRRHGLP- 51 GHN+ Q+ + S +K + T+ V R P Sbjct: 202 FQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPH 261 Query: 52 NLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVA 111 +V S + DRV ++ + + I A+++ P+G + + + Sbjct: 262 EFIVGLSNSKILHY--------DDRVS--ENQGLVQTYDHHLSSILALKYFPDGSKFISS 311 Query: 112 TYSGEFSLWNASSFTFETLMQAHDSAVTTMKY---SHDSDWMISGDADGMIKIWQPNFSM 168 + +W + + Q D+A +M + ++ + D I + Sbjct: 312 SEDKTVRIW--ENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKY 369 Query: 169 V---KEIDAAHTESIR--DMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGH-HWDV 222 K+I H+ + +AFS + + + L W+++ + + + + Sbjct: 370 KRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPI 429 Query: 223 KSCDWHPEM--GLIASASKDNLVKLWD 247 DWHP+ +I S + + + D Sbjct: 430 TQVDWHPQETSKVICSGAA-GKIYVCD 455 >5OQL-X nrPDB Length = 630 Score = 125 bits (314), Expect = 4e-29, Method: Composition-based stats. Identities = 43/280 (15%), Positives = 90/280 (32%), Gaps = 40/280 (14%) Query: 129 TLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSN 188 Q H A +K S D ++++G AD + ++ + H +++ +AF Sbjct: 240 KTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLKPIKAFTQHRDAVTGLAFRRG 299 Query: 189 DSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDP 248 ++ +CS D +K+W+ L GH ++ D + ++ ++D + W Sbjct: 300 TNQLYSCSKDRTVKVWSLDELAYVETLFGHQDEILDIDALGQERCVSVGARDRTARYWKV 359 Query: 249 RSGNCI----------SSILKFK-----------HTVLKTRFQPTKGNLLMAISKDKSCR 287 + + S+ K K H R ++ + S + Sbjct: 360 PEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAMIDDDMFVTGSDNGDLA 419 Query: 288 VFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPY 347 ++ I+ + R + +K D + IP Sbjct: 420 LWSIQRKKPLHVIARAH-------------------GLEPPIKLEDYSADEIPDPSIIPA 460 Query: 348 AHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNA 387 + IT+L P + + + D IR W + Sbjct: 461 PQPRGITALRTLPYSDLIFSGSWDGCIRVWRLSEDKRKLE 500 Score = 49.7 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 26/240 (10%), Positives = 56/240 (23%), Gaps = 31/240 (12%) Query: 210 KQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW---DPRSGNCISSILKFKHTVLK 266 + V S P + +KD + W D + K Sbjct: 161 ATYTQFRWNSGTVTSVAVCPPYAY--TTTKDGYLTKWKLQDLPKNQWPQTTKKKPKKPPA 218 Query: 267 TRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYD 326 + + + + + D Sbjct: 219 PPKKRPERICFA-----------KADARKANDKTYQGHLKAPLVVKASQDGKFVVTGGAD 267 Query: 327 GSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRAR--PID 384 L ++ + H +T L++ + + +KDRT++ W+ ++ Sbjct: 268 KRLVVYNAAD---LKPIKAFTQHRDAVTGLAFRRGTNQLYSCSKDRTVKVWSLDELAYVE 324 Query: 385 PNAYDDPTYNNKKINGWF--FGINNDINAVR-----EKSEF---GAAPPPPATLEPHALP 434 + G + R E+S+ G + + H LP Sbjct: 325 TLFGHQDEILDIDALGQERCVSVGARDRTARYWKVPEESQLVFRGGGEGGSSNTKKHKLP 384 >3BG0-A nrPDB Length = 316 Score = 124 bits (311), Expect = 7e-29, Method: Composition-based stats. Identities = 47/242 (19%), Positives = 84/242 (34%), Gaps = 30/242 (12%) Query: 167 SMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERV--LSGHHWDVKS 224 S++ +D +H + I D ++ TCS D +KI++ NG Q + L GH V Sbjct: 3 SVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQ 62 Query: 225 CDW-HPE-MGLIASASKDNLVKLWDPRSG--NCISSILKFKHTVLKTRFQPTK-GNLLMA 279 W HP ++AS S D V +W +G +V + P G +L Sbjct: 63 VAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILAC 122 Query: 280 ISKDKSCRVFDIRYSMK---ELMCVRDETDYMTLEW-----------HPINESM-----F 320 S D + + + + + + W HP + F Sbjct: 123 GSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRF 182 Query: 321 TLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPV----GHIFATAAKDRTIRF 376 D +K + ++ AH + +++ P A+ ++D + Sbjct: 183 ASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFI 242 Query: 377 WT 378 WT Sbjct: 243 WT 244 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 40/303 (13%), Positives = 96/303 (31%), Gaps = 37/303 (12%) Query: 90 NKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSF--TFETLMQAHDSAVTTMKYSHD- 146 + +I Q G RL + +++ + ++ H+ V + ++H Sbjct: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPM 69 Query: 147 -SDWMISGDADGMIKIWQPNFSM--VKEIDAAHTESIRDMAFSSNDS--KFVTCSDDNIL 201 + + S D + IW+ A H S+ + ++ +D S D + Sbjct: 70 YGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAI 129 Query: 202 KIWNFSNGKQE---RVLSGHHWDVKSCDW-----------HPEM------GLIASASKDN 241 + ++ Q ++ + H + W HP AS DN Sbjct: 130 SLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDN 189 Query: 242 LVKLWDPRSGNCI---SSILKFKHTVLKTRFQPTKG---NLLMAISKDKSCRVFDIRYSM 295 L+KLW + V + P+ G + + + S+D ++ + Sbjct: 190 LIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDAS 249 Query: 296 KELMCVRDETDYMTLEWH---PINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKC 352 + + + WH I ++ ++ D + + + ++ Sbjct: 250 SNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGS 309 Query: 353 ITS 355 +++ Sbjct: 310 VSA 312 Score = 115 bits (287), Expect = 5e-26, Method: Composition-based stats. Identities = 53/277 (19%), Positives = 104/277 (37%), Gaps = 40/277 (14%) Query: 52 NLVVEPETSYTIDIMPPNAYRGRDRVINLPS--KFTHLSSNKVKHVIPAIQWTP--EGRR 107 +++ + + Y + + ++ ++ + + + + + W G Sbjct: 14 DMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNI 73 Query: 108 LVVATYSGEFSLWNASSFTFETLMQ--AHDSAVTTMKYSHD--SDWMISGDADGMIKIWQ 163 L +Y + +W + T+E + HDS+V ++ ++ + G +DG I + Sbjct: 74 LASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLT 133 Query: 164 PNFS---MVKEIDAAHTESIRDMAFSS-----------------NDSKFVTCSDDNILKI 203 VK+I+ AHT ++++ +F + DN++K+ Sbjct: 134 YTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKL 193 Query: 204 WNFSNGKQERV---LSGHHWDVKSCDWHPEMGL----IASASKDNLVKLW--DPRSGNCI 254 W Q + L H V+ W P +GL IAS S+D V +W D S N Sbjct: 194 WKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTW 253 Query: 255 SS--ILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVF 289 S + KF V + T N+L D ++ Sbjct: 254 SPKLLHKFNDVVWHVSWSITA-NILAVSGGDNKVTLW 289 Score = 106 bits (265), Expect = 2e-23, Method: Composition-based stats. Identities = 48/288 (16%), Positives = 94/288 (32%), Gaps = 48/288 (16%) Query: 134 HDSAVTTMKYSHDSDWMISGDADGMIKIWQPN--FSMVKEIDAAHTESIRDMAF--SSND 189 H+ + + + + + +D +KI+ ++ H + +A+ Sbjct: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 Query: 190 SKFVTCSDDNILKIWNFSNGKQERVLS--GHHWDVKSCDWHP-EMGLIAS-ASKDNLVKL 245 + +CS D + IW NG E+ GH V S W P + GLI + S D + L Sbjct: 72 NILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131 Query: 246 --------WDPRSGNCISSILKFKHTVLKTRFQPT--KGNL--------------LMAIS 281 W+ + + P G+L + Sbjct: 132 LTYTGEGQWEVK-----KINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGG 186 Query: 282 KDKSCRVFDIRYSM--KELMCVRDETDYMT-LEWHPINE---SMFTLACYDGSLKHF--- 332 D +++ KE + +D++ + W P S DG + + Sbjct: 187 CDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCD 246 Query: 333 DLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRA 380 D N P L + + + +S++ +I A + D + W + Sbjct: 247 DASSNTWSPKL--LHKFNDVVWHVSWSITANILAVSGGDNKVTLWKES 292 Score = 49.7 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 13/108 (12%), Positives = 32/108 (29%), Gaps = 11/108 (10%) Query: 67 PPNAYRGRDRVINLPSKFT---HLSSNKVKHVIPAIQWTPE----GRRLVVATYSGEFSL 119 ++ + + W P + + G + Sbjct: 183 ASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFI 242 Query: 120 W---NASSFTFE-TLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ 163 W +ASS T+ L+ + V + +S ++ + D + +W+ Sbjct: 243 WTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 Score = 34.3 bits (77), Expect = 0.13, Method: Composition-based stats. Identities = 10/54 (18%), Positives = 20/54 (37%), Gaps = 4/54 (7%) Query: 342 ILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARP----IDPNAYDDP 391 I T+ +H+ I + G AT + DR+++ + I + Sbjct: 5 INTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEG 58 >2AQ5-A nrPDB Length = 402 Score = 122 bits (305), Expect = 4e-28, Method: Composition-based stats. Identities = 38/224 (16%), Positives = 94/224 (41%), Gaps = 21/224 (9%) Query: 130 LMQAHDSAVTTMKYSHDS-DWMISGDADGMIKIWQ-PNFSMVKEIDA------AHTESIR 181 L+ H + V + + + + + SG D + +W+ P+ +V + HT+ + Sbjct: 76 LVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVG 135 Query: 182 DMAFSSN-DSKFVTCSDDNILKIWNFSNGKQERVLSG--HHWDVKSCDWHPEMGLIASAS 238 +A+ + ++ DN++ +W+ G L H + S DW + LI ++ Sbjct: 136 IVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSC 195 Query: 239 KDNLVKLWDPRSGNCISSI-LKFKHT--VLKTRFQPTKGNLL---MAISKDKSCRVFDIR 292 +D V++ +PR G ++ + T V +G +L + ++ ++D + Sbjct: 196 RDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAVFVS--EGKILTTGFSRMSERQVALWDTK 253 Query: 293 YSMKELMC--VRDETDYMTLEWHPINESMFTLACYDGSLKHFDL 334 + + L + + + + P ++ D S+++F++ Sbjct: 254 HLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEI 297 Score = 104 bits (260), Expect = 7e-23, Method: Composition-based stats. Identities = 33/192 (17%), Positives = 68/192 (35%), Gaps = 13/192 (6%) Query: 217 GHHWDVKSCDWHPEMG-LIASASKDNLVKLWDPRSG-------NCISSILKFKHTVLKTR 268 GH V W P +IAS S+D V +W+ G + ++ V Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVA 138 Query: 269 FQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRD-ETDYMTLEWHPINESMFTLACYDG 327 + PT N+L++ D V+D+ L D D + + ++ +C D Sbjct: 139 WHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCRDK 198 Query: 328 SLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATA---AKDRTIRFWTRARPID 384 ++ + + P+ + + ++ + G I T +R + W + Sbjct: 199 RVRVIEPRKGTVVAEKDRPHEGTRPVHAV-FVSEGKILTTGFSRMSERQVALWDTKHLEE 257 Query: 385 PNAYDDPTYNNK 396 P + + ++ Sbjct: 258 PLSLQELDTSSG 269 Score = 101 bits (251), Expect = 7e-22, Method: Composition-based stats. Identities = 39/262 (14%), Positives = 81/262 (30%), Gaps = 26/262 (9%) Query: 53 LVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTP-EGRRLVVA 111 L+ E ++P D+ N+P H + + I W P + Sbjct: 49 LICEASGGGAFLVLPLGKTGRVDK--NVPLVCGHTA------PVLDIAWCPHNDNVIASG 100 Query: 112 TYSGEFSLWNASSFTFET-------LMQAHDSAVTTMKYSHDS-DWMISGDADGMIKIWQ 163 + +W ++ H V + + + + ++S D +I +W Sbjct: 101 SEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWD 160 Query: 164 PNFSMVKEIDA--AHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWD 221 H ++I + +S + + T D +++ G H Sbjct: 161 VGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKGTVVAEKDRPHEG 220 Query: 222 VKSCD--WHPEMGLIASA---SKDNLVKLWDPRSGNCISSILKFKHT--VLKTRFQPTKG 274 + + E ++ + + V LWD + S+ + + VL F P Sbjct: 221 TRPVHAVFVSEGKILTTGFSRMSERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTN 280 Query: 275 NLLMAISKDKSCRVFDIRYSMK 296 + + D S R F+I Sbjct: 281 IVYLCGKGDSSIRYFEITSEAP 302 Score = 62.8 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 20/141 (14%), Positives = 46/141 (32%), Gaps = 17/141 (12%) Query: 246 WDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDET 305 WD SG C + + + G + + K+ RV + Sbjct: 35 WD--SGFC-----AVNPKFMALICEASGGGAFLVLPLGKTGRV-----DKNVPLVCGHTA 82 Query: 306 DYMTLEWHPINESMFTLACYDGSLKHFDLLQN----LNEPILTIPYAHDKCITSLSYNPV 361 + + W P N+++ D ++ +++ + H K + ++++P Sbjct: 83 PVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPT 142 Query: 362 -GHIFATAAKDRTIRFWTRAR 381 ++ +A D I W Sbjct: 143 AQNVLLSAGCDNVILVWDVGT 163 >4XFV-A nrPDB Length = 792 Score = 121 bits (303), Expect = 7e-28, Method: Composition-based stats. Identities = 57/381 (14%), Positives = 116/381 (30%), Gaps = 80/381 (20%) Query: 73 GRDRVINL---PSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLW---NASSFT 126 + + +K + + + + +++ P+ +V A+ +W + S Sbjct: 40 KTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQ 99 Query: 127 FETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIR----- 181 +Q + + + + G ADG I IW+ N E AH +I+ Sbjct: 100 CIQTIQHYSKTIVALSALP--SLISVGCADGTISIWRQNIQN-DEFGLAHEFTIKKGFFY 156 Query: 182 --DMAFSS---NDSKFVTCSDDNILKIWNF-------SNGKQERVLSGHHWDVKSCDW-- 227 ++ S + + I +F + L GH VKS + Sbjct: 157 PLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRH 216 Query: 228 --HPEMGLIASASKDNLVKLWDPRSGNCISS----------------------------- 256 P L+ S S+D ++LW R + I Sbjct: 217 QETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGIN 276 Query: 257 ----ILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMC------------ 300 I+ + ++ ++ LL A + D S V++ + +C Sbjct: 277 FEALIMGHDDWISSLQWHESRLQLLAA-TADTSLMVWEPDETSGIWVCSLRLGEMSSKGA 335 Query: 301 ---VRDETDYMTLEWHPINES-MFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSL 356 + + W F GS + + N+ K +T + Sbjct: 336 STATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDI 395 Query: 357 SYNPVGHIFATAAKDRTIRFW 377 +++P G + D+T R + Sbjct: 396 AWSPSGEYLLATSLDQTTRLF 416 Score = 112 bits (280), Expect = 3e-25, Method: Composition-based stats. Identities = 46/231 (19%), Positives = 89/231 (38%), Gaps = 28/231 (12%) Query: 190 SKFVTCSDDNILKIWNF---SNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW 246 K V + +W+ +N L GH +V + P+ + SAS+D+ VK+W Sbjct: 31 KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIW 90 Query: 247 ---DPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVF------DIRYSMKE 297 D CI +I + T++ P +L+ D + ++ D E Sbjct: 91 KFTDYSHLQCIQTIQHYSKTIVALSALP---SLISVGCADGTISIWRQNIQNDEFGLAHE 147 Query: 298 LMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNE------PILTIPYAHDK 351 + + L + E + LA ++ F L++ ++ H+ Sbjct: 148 FTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHED 207 Query: 352 CITSLSY----NPVGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKI 398 + SL++ P ++ + ++DR IR W I+ DD ++KK+ Sbjct: 208 WVKSLAFRHQETPGDYLLCSGSQDRYIRLWRI--RINDL-IDDSEEDSKKL 255 Score = 97.1 bits (240), Expect = 1e-20, Method: Composition-based stats. Identities = 55/299 (18%), Positives = 113/299 (37%), Gaps = 42/299 (14%) Query: 106 RRLVVATYSGEFSLWNA---SSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIW 162 +++V +LW+ ++ ++ H++ VT +++ DSD+M+S D +KIW Sbjct: 31 KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIW 90 Query: 163 ---QPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHH 219 + + ++++I +A S+ S D + IW N + + H Sbjct: 91 KFTDYSHLQCIQTIQHYSKTI--VALSALPSLISVGCADGTISIW-RQNIQNDEFGLAHE 147 Query: 220 WDVKSCDWHP----------EMGLIASASKDNLV-----KLWDPRSGNC--ISSILKFKH 262 + +K ++P + L+A + V L D C ++ + + Sbjct: 148 FTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHED 207 Query: 263 TVLKTRFQPTK---GNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESM 319 V F+ + LL + S+D+ R++ IR + + E D L + Sbjct: 208 WVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRIND---LIDDSEEDSKKLTLLSNKQYK 264 Query: 320 FTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWT 378 F + D L+ + + HD I+SL ++ A D ++ W Sbjct: 265 FQI---DDELRVGINFE-------ALIMGHDDWISSLQWHESRLQLLAATADTSLMVWE 313 Score = 86.7 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 38/232 (16%), Positives = 76/232 (32%), Gaps = 28/232 (12%) Query: 131 MQAHDSAVTTMKYSHDSDWMISGDADGM-----IKIWQPNFSM-VKEIDAAHTESIRDMA 184 + H +T + S D + S I+I+ + +K H+ +I + Sbjct: 558 LYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLK 617 Query: 185 FSSNDSKFVTCSDDNILKIW--NFSNGKQERVLSG---HHWDVKSCDWHP--EMGLIASA 237 FS + ++ D +W N + E H + DW P + +A Sbjct: 618 FSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTA 677 Query: 238 SKDNLVKLW----DPRSGNCISSILKFKHTVLKTRFQPT---KGNLLMAISKDKSCRVFD 290 S+D VK+W +P + + +K V + + L+ ++ ++ Sbjct: 678 SRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYS 737 Query: 291 IRYSMKELMCVRDETD-----YMTLEWH---PINESMFTLACYDGSLKHFDL 334 EL+ +E L W + + D S + + L Sbjct: 738 YTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYSL 789 Score = 82.5 bits (202), Expect = 4e-16, Method: Composition-based stats. Identities = 59/434 (13%), Positives = 119/434 (27%), Gaps = 116/434 (26%) Query: 92 VKHVIPAIQW----TPEGRRLVVATYSGEFSLW----------NASSFTFETLMQ----- 132 + + ++ + TP L + LW + TL+ Sbjct: 205 HEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYK 264 Query: 133 ------------------AHDSAVTTMKYSHDSDWMISGDADGMIKIWQPN--------- 165 HD ++++++ +++ AD + +W+P+ Sbjct: 265 FQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCS 324 Query: 166 ------FSMVKEIDAAHTESIRDMAFSSND--SKFVTCSDDNILKIW---NFSNGKQERV 214 S + + +++ F+T ++W + Q Sbjct: 325 LRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLG 384 Query: 215 LSGHHWDVKSCDWHPEMGLIASASKDNLVKL---W--DPRSGNCISSILKFK------HT 263 +SG DV W P + + S D +L W D SG + H Sbjct: 385 ISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDA-SGRKREIATWHEFSRPQIHG 443 Query: 264 VLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLA 323 + ++ +K R FD+ + ++ + P + ++ L Sbjct: 444 YDMICVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLG 503 Query: 324 CYDG-------------------SLKHFDLLQNLNE-------------PILTIPYAHDK 351 + + D L L P + Y H Sbjct: 504 LSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKLYGHGF 563 Query: 352 CITSLSYNPVGHIFATAAKDR-----TIRF-----WTRARPIDPNAYDDPTYNNKKINGW 401 IT L +P + A+A + IR W +P P T +G Sbjct: 564 EITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGK 623 Query: 402 FFGINNDINAVREK 415 F ++ R++ Sbjct: 624 FL-----LSVCRDR 632 Score = 79.8 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 46/243 (18%), Positives = 93/243 (38%), Gaps = 35/243 (14%) Query: 86 HLSSNKVKHV------IPAIQWTPEGRRLVVATYSGE-----FSLWNASS-FTFETLMQA 133 HL +V+ + I + +P+ + + A S +++ + + + Sbjct: 549 HLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPF 608 Query: 134 HDSAVTTMKYSHDSDWMISGDADGMIKIWQPN-----FSMVKEIDAAHTESIRDMAFSS- 187 H +T +K+S D +++S D +W+ N F + + + HT I D ++ Sbjct: 609 HSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPL 668 Query: 188 -NDSKFVTCSDDNILKIWNFS-NGKQERVLSG---HHWDVKSCDWHPE---MGLIASAS- 238 + FVT S D +K+W + VL H V + H ++ S Sbjct: 669 EFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGL 728 Query: 239 KDNLVKLWDPRSG--NCISSILKF---KHTVLKTRFQPTKGN---LLMAISKDKSCRVFD 290 ++ + L+ G I+ + + + + R+ K N L S D S R++ Sbjct: 729 ENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYS 788 Query: 291 IRY 293 + Y Sbjct: 789 LAY 791 Score = 72.1 bits (175), Expect = 4e-13, Method: Composition-based stats. Identities = 60/439 (13%), Positives = 148/439 (33%), Gaps = 93/439 (21%) Query: 61 YTIDIMPPNAYRGRDRVINLPSKF---THLSSNKVKHVIPAIQWTPEGRRLVVATYSGEF 117 +D N G R+ L + + I W+P G L+ + Sbjct: 354 ERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTT 413 Query: 118 S-----LWNASSFTFETLM-------QAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPN 165 +++AS E Q H + ++ D+ +SG + +++ + Sbjct: 414 RLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTR-FVSGGDEKILRSFDLP 472 Query: 166 F------------SMVKEIDAAHTESIRDMAFS-------------------------SN 188 ++ + + ++ + S ++ Sbjct: 473 KGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITD 532 Query: 189 DSKFVTCS--DDNILK--IWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASK----- 239 + C +D + + +W + L GH +++ D P+ LIASA + Sbjct: 533 PLSLLECPPMEDQLQRHLLW-----PEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQ 587 Query: 240 DNLVKLWDPRSG-NCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVF-----DIRY 293 + +++++ + ++ T+ + +F G L+++ +D+ ++ D + Sbjct: 588 NAVIRIFSTENWLEIKPALPFHSLTITRLKFS-KDGKFLLSVCRDRKWALWERNMEDNTF 646 Query: 294 SMKELMCVRDETDYMTLEWHPIN-ESMFTLACYDGSLKHFDLLQNL-NEPILTIPYAHDK 351 ++ +W P+ ++F A D ++K + + ++ +L H K Sbjct: 647 ELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTK 706 Query: 352 CITSLSYNPVG---HIFATAA-KDRTIRFWTRA---RPIDPNAYDDPTYNNK-------- 396 +T++S + I + ++ I ++ + +D T +K Sbjct: 707 AVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKFELITQLNEDITPADKITRLRWSH 766 Query: 397 -KINGWFF-GINNDINAVR 413 K NG F G+ + + R Sbjct: 767 LKRNGKLFLGVGSSDLSTR 785 Score = 57.8 bits (138), Expect = 9e-09, Method: Composition-based stats. Identities = 48/329 (14%), Positives = 103/329 (31%), Gaps = 40/329 (12%) Query: 76 RVINLPSKFTHLSSNKVKHVIPAIQWTPEG-RRLVVATYSGEFSLWNASSFTF---ETLM 131 R+ + SK ++ + +T E + +G + +W + Sbjct: 326 RLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGI 385 Query: 132 QAHDSAVTTMKYSHDSDWMISGDADGMIKIWQP----NFSMVKEIDAAHT---ESIRD-- 182 VT + +S +++++ D +++ P +EI H I Sbjct: 386 SGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYD 445 Query: 183 --MAFSSNDSKFVTCSDDNILKIWNFSNG--KQERVLSGHHWDVKSCDWHPEMGLIASAS 238 + D++FV+ D+ IL+ ++ G + G ++ KS P+ + Sbjct: 446 MICVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKS--EMPDSATVPVLG 503 Query: 239 KDNLV-----KLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRY 293 N D + P + L + ++ Sbjct: 504 LSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHL-------LW---- 552 Query: 294 SMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYA---HD 350 E+ + +T ++ + AC ++++ + E L I A H Sbjct: 553 --PEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHS 610 Query: 351 KCITSLSYNPVGHIFATAAKDRTIRFWTR 379 IT L ++ G + +DR W R Sbjct: 611 LTITRLKFSKDGKFLLSVCRDRKWALWER 639 >4OWR-A nrPDB Length = 339 Score = 118 bits (296), Expect = 4e-27, Method: Composition-based stats. Identities = 44/269 (16%), Positives = 94/269 (34%), Gaps = 29/269 (10%) Query: 135 DSAVTTMKYSHD---SDWMISGDADGMIKIWQPN--FSMVKEIDAAHTESIRDMAFSSND 189 D ++ + +S +++I+G ++ W+ + + HT + D+ +S + Sbjct: 10 DDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDG 69 Query: 190 SKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDW--HPEMGLIASASKDNLVKLWD 247 SK T S D K+W+ S+ + + ++ H VK+ W P + + S D +K WD Sbjct: 70 SKVFTASCDKTAKMWDLSSNQAIQ-IAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWD 128 Query: 248 PRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRD---- 303 RS N + + + P + + + ++ V+ + E + Sbjct: 129 TRSSNPMMVLQLPERCYCADVIYP----MAVVATAERGLIVYQLENQPSEFRRIESPLKH 184 Query: 304 -ETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKC---------- 352 + + F L +G + + H Sbjct: 185 QHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDI 244 Query: 353 --ITSLSYNPVGHIFATAAKDRTIRFWTR 379 + ++++PV AT D FW + Sbjct: 245 YAVNGIAFHPVHGTLATVGSDGRFSFWDK 273 Score = 105 bits (261), Expect = 5e-23, Method: Composition-based stats. Identities = 58/305 (19%), Positives = 110/305 (36%), Gaps = 31/305 (10%) Query: 91 KVKHVIPAIQWTPE---GRRLVVATYSGEFSLWNASS--FTFETLMQAHDSAVTTMKYSH 145 I + ++P G L+ +++ + W T Q H V + +S Sbjct: 8 SPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSD 67 Query: 146 DSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAF--SSNDSKFVTCSDDNILKI 203 D + + D K+W + + +I A H ++ + + + N S +T S D LK Sbjct: 68 DGSKVFTASCDKTAKMWDLSSNQAIQI-AQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKF 126 Query: 204 WNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWD--PRSGNCISSILKFK 261 W+ + VL D M ++A+A + +V + P I S LK + Sbjct: 127 WDTRSSNPMMVLQ-LPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQ 185 Query: 262 H---TVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETD------------ 306 H + K + G L +I + + K+ + Sbjct: 186 HRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIY 245 Query: 307 -YMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIF 365 + +HP++ ++ T+ DG +D L D+ I++ +N G+IF Sbjct: 246 AVNGIAFHPVHGTLATVGS-DGRFSFWD---KDARTKLKTSEQLDQPISACCFNHNGNIF 301 Query: 366 ATAAK 370 A A+ Sbjct: 302 AYASS 306 Score = 89.0 bits (219), Expect = 4e-18, Method: Composition-based stats. Identities = 37/282 (13%), Positives = 80/282 (28%), Gaps = 65/282 (23%) Query: 66 MPPNAYRGRDRVINLPSKFTHLSSNKVKH--VIPAIQWTPEGRRLVVATYSGEFSLWNAS 123 + ++ R + + + H + + W+ +G ++ A+ +W+ S Sbjct: 28 LIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLS 87 Query: 124 SFTFETLMQAHDSAVTTMKY--SHDSDWMISGDADGMIKIWQPNFS-------------- 167 S + Q HD+ V T+ + + + +++G D +K W S Sbjct: 88 SNQAIQIAQ-HDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPERCYC 146 Query: 168 ---------------------------MVKEIDAAHTESIRDMAFSSND----SKFVTCS 196 + I++ R +A + + F S Sbjct: 147 ADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHRCVAIFKDKQNKPTGFALGS 206 Query: 197 DDNILKIWNFSNGKQER---VLSGHHW------------DVKSCDWHPEMGLIASASKDN 241 + + I + + H V +HP G +A+ D Sbjct: 207 IEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDG 266 Query: 242 LVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKD 283 WD + + + + + F A S D Sbjct: 267 RFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASSYD 308 Score = 56.3 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 13/102 (12%), Positives = 34/102 (33%), Gaps = 4/102 (3%) Query: 299 MCVRDETDYMTLEWHP--INESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSL 356 + + L + P + + + ++ +++ Q+ + I H + + Sbjct: 5 VTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEV-QDSGQTIPKAQQMHTGPVLDV 63 Query: 357 SYNPVGHIFATAAKDRTIRFWTR-ARPIDPNAYDDPTYNNKK 397 ++ G TA+ D+T + W + A D Sbjct: 64 CWSDDGSKVFTASCDKTAKMWDLSSNQAIQIAQHDAPVKTIH 105 >3ACP-A nrPDB Length = 417 Score = 118 bits (296), Expect = 5e-27, Method: Composition-based stats. Identities = 67/313 (21%), Positives = 116/313 (37%), Gaps = 39/313 (12%) Query: 130 LMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSND 189 L +A +AV T K I G +G IK+ NF++ +EID AH I + F + Sbjct: 91 LKRADYTAVDTAKLQ--MRRFILGTTEGDIKVLDSNFNLQREIDQAHVSEITKLKFFPSG 148 Query: 190 SKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPR 249 ++ S D LKIW+ +G R L GH V + SAS D ++LW+ Sbjct: 149 EALISSSQDMQLKIWSVKDGSNPRTLIGHRATVTDIAIIDRGRNVLSASLDGTIRLWECG 208 Query: 250 SGNCISSILKFKHT---VLKTR-FQPTKGNLL-MAISKDKSCRV-----FDIRYSMKELM 299 +G I + + ++ V F T L ++ SK + + I + ++ Sbjct: 209 TGTTIHTFNRKENPHDGVNSIALFVGTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVI 268 Query: 300 CVRD--------------ETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTI 345 V + +L N + +G L +DL + P+ Sbjct: 269 TVHNVFSKEQTIQLPSKFTCSCNSLTVDGNNANYIYAGYENGMLAQWDLR-SPECPVGEF 327 Query: 346 PYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFFGI 405 I ++ + G +F ++ D +I+ + P + F + Sbjct: 328 LINEGTPINNVYFAA-GALFVSSGFDTSIKLDIISDPESERPAIEFETPT-------FLV 379 Query: 406 NNDINAVREKSEF 418 +ND E S+F Sbjct: 380 SNDD----EVSQF 388 Score = 94.0 bits (232), Expect = 1e-19, Method: Composition-based stats. Identities = 39/287 (13%), Positives = 86/287 (29%), Gaps = 33/287 (11%) Query: 69 NAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFE 128 G +V++ I +++ P G L+ ++ + +W+ + Sbjct: 112 GTTEGDIKVLDSNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNP 171 Query: 129 TLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEI----DAAHTESIRDMA 184 + H + VT + ++S DG I++W+ + H + + +A Sbjct: 172 RTLIGHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPH-DGVNSIA 230 Query: 185 ---------------------FSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDV- 222 F + + ++ + N + +Q L Sbjct: 231 LFVGTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLPSKFTCSC 290 Query: 223 KSCDWHPEM-GLIASASKDNLVKLWDPRSGNCI--SSILKFKHTVLKTRFQPTKGNLLMA 279 S I + ++ ++ WD RS C ++ + F G L ++ Sbjct: 291 NSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVGEFLINEGTPINNVYFAA--GALFVS 348 Query: 280 ISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYD 326 D S ++ DI + + L + S F D Sbjct: 349 SGFDTSIKL-DIISDPESERPAIEFETPTFLVSNDDEVSQFCYVSDD 394 Score = 39.7 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 38/250 (15%), Positives = 84/250 (33%), Gaps = 43/250 (17%) Query: 3 GHNQNQYQ------NQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVE 56 GH +N + S ++ + + + N N G+ ++ + Sbjct: 176 GHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGT---TIHTFNRKENPHDGVNSIAL- 231 Query: 57 PETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGE 116 + G DR + +S++K + +++ G+ ++ SG Sbjct: 232 --------------FVGTDR------QLHEISTSKKNN----LEFGTYGKYVIAGHVSGV 267 Query: 117 FSLWNASSFTFETLMQAHDSAVTTM-KYSHDS---DWMISGDADGMIKIWQPNF--SMVK 170 ++ N F+ E +Q + + D +++ +G +GM+ W V Sbjct: 268 ITVHNV--FSKEQTIQLPSKFTCSCNSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVG 325 Query: 171 EIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPE 230 E I ++ F++ + FV+ D +K+ S+ + ER E Sbjct: 326 EFLINEGTPINNVYFAA-GALFVSSGFDTSIKLDIISDPESERPAIEFETPTFLVSNDDE 384 Query: 231 MGLIASASKD 240 + S D Sbjct: 385 VSQFCYVSDD 394 >5K19-A nrPDB Length = 569 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 59/350 (16%), Positives = 107/350 (30%), Gaps = 39/350 (11%) Query: 25 KYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKF 84 Y R++ D+S P Y + + + G+ ++I+ K Sbjct: 77 IYKGVRKAADLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLVGFSAGQVQLIDPIKKE 136 Query: 85 THLSSNK----VKHVIPAIQWTPEGR-RLVVATYSGEFSLWNASSFT------FETLMQA 133 T N+ K + ++W P +VA SG L+N ++ L Q Sbjct: 137 TSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQG 196 Query: 134 HDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFV 193 AV T K + ++ W + E AFS + Sbjct: 197 ESFAVHTCKSKSTRNPLLK---------WTVGEGALNEF-----------AFSPDGKFLA 236 Query: 194 TCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNC 253 S D L+++NF + + + + + W P+ I + +D+LV +W Sbjct: 237 CVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRV 296 Query: 254 ISSILKFKHTVLKTRFQP------TKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDY 307 I+ K V F P + + S + + R Sbjct: 297 IARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRN 356 Query: 308 MTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYA--HDKCITS 355 T F D L +DL +++ P + A H + + Sbjct: 357 STDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTHTNVMNA 406 Score = 55.5 bits (132), Expect = 5e-08, Method: Composition-based stats. Identities = 22/193 (11%), Positives = 50/193 (25%), Gaps = 38/193 (19%) Query: 241 NLVKLWDPRSGNCISSILK----FKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYS-- 294 V+L DP + K V ++ P +L + + ++++ ++ Sbjct: 125 GQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCG 184 Query: 295 --------------------------MKELMCVRDETDYMTLEWHPINESMFTLACYDGS 328 L E + P + DG Sbjct: 185 TTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSP-DGKFLACVSQDGF 243 Query: 329 LKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTR--ARPIDPN 386 L+ F+ + + + + ++P G T +D + W+ R I Sbjct: 244 LRVFNFDSVELHGTMKSYFG---GLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARG 300 Query: 387 AYDDPTYNNKKIN 399 + + Sbjct: 301 HGHKSWVSVVAFD 313 Score = 53.6 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 30/254 (11%), Positives = 81/254 (31%), Gaps = 39/254 (15%) Query: 121 NASSFTFETLMQAHDSAV---TTMKYSHDSDWMISGDADGMIKIWQP----NFSMVKEID 173 + S + + + + + +S ++ G + G +++ P + E Sbjct: 86 DLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLVGFSAGQVQLIDPIKKETSKLFNEER 145 Query: 174 AAHTESIRDMAFSSND-SKFVTCSDDNILKIWNFSN------GKQERVLSGHHWDVKSCD 226 + + + S F+ + ++N + + + G + V +C Sbjct: 146 LIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCK 205 Query: 227 WHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSC 286 ++++ L+K W G + + F P G L +S+D Sbjct: 206 SK--------STRNPLLK-WTVGEG-----------ALNEFAFSP-DGKFLACVSQDGFL 244 Query: 287 RVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIP 346 RVF+ + + W P + D + + + ++ Sbjct: 245 RVFNFDSVELHGTMKSYFGGLLCVCWSP-DGKYIVTGGEDDLVTVWSFVD---CRVIARG 300 Query: 347 YAHDKCITSLSYNP 360 + H ++ ++++P Sbjct: 301 HGHKSWVSVVAFDP 314 >5OV3-A nrPDB Length = 381 Score = 116 bits (291), Expect = 2e-26, Method: Composition-based stats. Identities = 41/198 (20%), Positives = 75/198 (37%), Gaps = 3/198 (1%) Query: 183 MAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNL 242 F+ + +D + IW+F +++S H V S W + + SAS DN+ Sbjct: 31 CTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNI 90 Query: 243 VKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVR 302 V WD SG+C +F +LK ++ P N ++ + + + S ++ V Sbjct: 91 VSQWDVLSGDCDQRF-RFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVD 149 Query: 303 DETDYMTLEWHPINESMFTLACYDGSLKHF--DLLQNLNEPILTIPYAHDKCITSLSYNP 360 D++D + G + D + +T ++ I S+ + Sbjct: 150 DDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFAR 209 Query: 361 VGHIFATAAKDRTIRFWT 378 G F DR IR + Sbjct: 210 KGSCFLINTADRIIRVYD 227 Score = 107 bits (266), Expect = 1e-23, Method: Composition-based stats. Identities = 43/307 (14%), Positives = 101/307 (32%), Gaps = 21/307 (6%) Query: 88 SSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDS 147 + + + G L V G +W+ + ++ AH V ++ +S D Sbjct: 20 GTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDG 79 Query: 148 DWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSS-NDSKFVTCSDDNILKIWNF 206 ++S D ++ W + I + + + +K + C + + Sbjct: 80 HKLVSASTDNIVSQWDVLSGDCDQRFRF-PSPILKVQYHPRDQNKVLVCPMKSAPVMLTL 138 Query: 207 SNGKQERVLSGHHWDVKSCD-WHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVL 265 S+ K + D+ + I + + + + S + ++S T Sbjct: 139 SDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSN 198 Query: 266 KTRF----QPTKGNLLMAISKDKSCRVFDIR-----------YSMKELMCVRDETDYMTL 310 T KG+ + + D+ RV+D R M++L + + T + Sbjct: 199 TTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKC 258 Query: 311 EWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAK 370 + E + + +L ++ IL + ++++PV I A+ + Sbjct: 259 CFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGE--LLLDVAWHPVRPIIASISS 316 Query: 371 DRTIRFW 377 + W Sbjct: 317 -GVVSIW 322 >5CXC-A nrPDB Length = 510 Score = 112 bits (281), Expect = 3e-25, Method: Composition-based stats. Identities = 60/372 (16%), Positives = 114/372 (30%), Gaps = 113/372 (30%) Query: 103 PEGRRLVVATYSGEFSLWNASSFTFETL----MQAHDSAVTTMKYSHDSDWMISGDADGM 158 P R++ A+Y G +WNAS T H +++ K+ SD + S D Sbjct: 156 PGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKF-LTSDRLASAGMDRT 214 Query: 159 IKIWQPN-----FSMVKEIDA--AHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGK- 210 +++W+ +K HT S+ + + +T S D + W+ S Sbjct: 215 VRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSASKASA 274 Query: 211 -----------------------------QERVLSGHHWDVKSCDWHPEMGLIA-SASKD 240 + S H + + P +A SAS+D Sbjct: 275 PEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQD 334 Query: 241 NLVKLWDPRSGNCISSIL------------------------------------------ 258 + V+ D +G +S++ Sbjct: 335 HTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDPRASSATT 394 Query: 259 ------KFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEW 312 + V+ P L++ S D +CRV+D+R Sbjct: 395 SVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLR------------------SV 436 Query: 313 HPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKC-ITSLSYNPVGHIFATAAKD 371 P + +L + + ++ P A D C + S+ ++ +G + +D Sbjct: 437 RPATKEEGSLGGVSEPVYVIERESWASKGKKKRPVAGDGCKVFSVVWDKLG--IFSGGED 494 Query: 372 RTIRFWTRARPI 383 + ++ R R I Sbjct: 495 KKVQV-NRGRNI 505 Score = 56.3 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 24/160 (15%), Positives = 51/160 (31%), Gaps = 13/160 (8%) Query: 277 LMAISKDKSCRVFDIRYSM----KELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHF 332 +++ S D R+++ S+ ++ + A D +++ + Sbjct: 161 VLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSD--RLASAGMDRTVRVW 218 Query: 333 -----DLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNA 387 D +P L + H + L + TA+ D I FW+ ++ P Sbjct: 219 KYTESDHFTGELKPTLELY-GHTGSVDWLDVDGHSKHILTASADGAIGFWSASKASAP-E 276 Query: 388 YDDPTYNNKKINGWFFGINNDINAVREKSEFGAAPPPPAT 427 D ++ ++ A R + PAT Sbjct: 277 PDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPAT 316 >6E29-D nrPDB Length = 345 Score = 110 bits (276), Expect = 9e-25, Method: Composition-based stats. Identities = 41/213 (19%), Positives = 81/213 (38%), Gaps = 22/213 (10%) Query: 54 VVEP-ETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVAT 112 + EP E Y + +P D P+ + KH+ AI +T G L+ T Sbjct: 138 ITEPVEVRYVLPSVPKRTSTETD-----PALREKQAKEDAKHMTTAIVYTASGDHLLAGT 192 Query: 113 YSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIW---------- 162 G ++ +A + + +TT++ + ++ D +I+ + Sbjct: 193 TKGRLNIIDARTREIIYSEKIASGIITTLRLTESGRELLVNAQDRIIRTFIVPNLSAADL 252 Query: 163 QPNFSMV----KEIDAAHTESIRDMAFSSNDSKFV-TCSDDNILKIWNFSNGKQERVLSG 217 P+ + K D + S +AFS+ + +++ L IW +G R+L G Sbjct: 253 DPDTIQLPLEHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIWERGHGSLVRMLEG 312 Query: 218 HHWDVKSCDWHPEMGLIASASKD-NLVKLWDPR 249 + +WHP L+A+ + + +W Sbjct: 313 PKEEQGVIEWHPHRALLAACGLETGRINIWSVT 345 Score = 89.4 bits (220), Expect = 3e-18, Method: Composition-based stats. Identities = 33/322 (10%), Positives = 90/322 (27%), Gaps = 43/322 (13%) Query: 97 PAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDAD 156 +++ +G L G +W+ + ++ H +T++ +S +++S Sbjct: 29 TCVRFNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWSRCGRYLLSACQG 88 Query: 157 GMIKIWQPNFSMVKEIDAAHTESIRDMAFSS-NDSKFVTCSDDNILKIWNFSNGKQER-- 213 + +W + + + N +F ++ + + + + R Sbjct: 89 WKVILWDLQDGK-RYREVRFRAPVYGAELHPWNHHQFAAALFEDQPMLVDITEPVEVRYV 147 Query: 214 --------------------VLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNC 253 + + + + + + + D R+ Sbjct: 148 LPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGDHLLAGTTKGRLNIIDARTREI 207 Query: 254 ISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVF--------DIRYSM------KELM 299 I S + R G L+ ++D+ R F D+ + Sbjct: 208 IYSEKIASGIITTLRLT-ESGRELLVNAQDRIIRTFIVPNLSAADLDPDTIQLPLEHKFQ 266 Query: 300 CVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYN 359 V + + + + E + + L ++ +L P I ++ Sbjct: 267 DVVNRLSWNHVAFSATGEYVAASTYNNHELYIWERGHGSLVRMLEGPKEEQGVI---EWH 323 Query: 360 PVGHIFATAA-KDRTIRFWTRA 380 P + A + I W+ Sbjct: 324 PHRALLAACGLETGRINIWSVT 345 Score = 87.9 bits (216), Expect = 9e-18, Method: Composition-based stats. Identities = 40/234 (17%), Positives = 67/234 (28%), Gaps = 28/234 (11%) Query: 163 QPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDV 222 ++ I + H+ + F+ + D + IW+ R L GH ++ Sbjct: 14 DYPENITNTIRSGHS---TCVRFNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNI 70 Query: 223 KSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISK 282 S W + SA + V LWD + G + +F+ V P + A Sbjct: 71 TSLSWSRCGRYLLSACQGWKVILWDLQDGKRYREV-RFRAPVYGAELHPWNHHQFAAALF 129 Query: 283 DKSCRVFDIRYSMKELMCV---------------------RDETDYMTLEWHPINESMFT 321 + + DI ++ + D T + + Sbjct: 130 EDQPMLVDITEPVEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGDHLL 189 Query: 322 LACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIR 375 G L D I IT+L G A+DR IR Sbjct: 190 AGTTKGRLNIIDARTREIIYSEKIASG---IITTLRLTESGRELLVNAQDRIIR 240 Score = 72.9 bits (177), Expect = 3e-13, Method: Composition-based stats. Identities = 30/308 (9%), Positives = 84/308 (27%), Gaps = 38/308 (12%) Query: 64 DIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNAS 123 D + G + +L + I ++ W+ GR L+ A + LW+ Sbjct: 38 DFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWSRCGRYLLSACQGWKVILWDLQ 97 Query: 124 SFTFETLMQAHDSAVTTMKYSH-DSDWMISGDA-------DGM--IKIWQPNFSMVKEID 173 ++ + V + + + D +++ S+ K Sbjct: 98 DGKRYREVRF-RAPVYGAELHPWNHHQFAAALFEDQPMLVDITEPVEVRYVLPSVPKRTS 156 Query: 174 AAHT-------------ESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHW 220 + ++++ + + L I + + Sbjct: 157 TETDPALREKQAKEDAKHMTTAIVYTASGDHLLAGTTKGRLNIIDARTREIIYSEKIASG 216 Query: 221 DVKSCDWHPEMGLIASASKDNLVKLW--------DPRSGNCISSIL-KFKHTV-----LK 266 + + + ++D +++ + D + KF+ V Sbjct: 217 IITTLRLTESGRELLVNAQDRIIRTFIVPNLSAADLDPDTIQLPLEHKFQDVVNRLSWNH 276 Query: 267 TRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYD 326 F T + + + +++ + M + + +EWHP + Sbjct: 277 VAFSATGEYVAASTYNNHELYIWERGHGSLVRMLEGPKEEQGVIEWHPHRALLAACGLET 336 Query: 327 GSLKHFDL 334 G + + + Sbjct: 337 GRINIWSV 344 Score = 50.5 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 14/73 (19%), Positives = 27/73 (36%), Gaps = 4/73 (5%) Query: 309 TLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATA 368 + ++ + DG++ +DL + H K ITSLS++ G +A Sbjct: 30 CVRFNRKGD-FLASGRVDGTVVIWDLET---MGVARKLRGHSKNITSLSWSRCGRYLLSA 85 Query: 369 AKDRTIRFWTRAR 381 + + W Sbjct: 86 CQGWKVILWDLQD 98 Score = 37.0 bits (84), Expect = 0.015, Method: Composition-based stats. Identities = 11/46 (23%), Positives = 15/46 (32%), Gaps = 3/46 (6%) Query: 334 LLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTR 379 L TI H C+ +N G A+ D T+ W Sbjct: 12 LQDYPENITNTIRSGHSTCVR---FNRKGDFLASGRVDGTVVIWDL 54 >2PM9-A nrPDB Length = 416 Score = 108 bits (270), Expect = 5e-24, Method: Composition-based stats. Identities = 51/308 (16%), Positives = 115/308 (37%), Gaps = 31/308 (10%) Query: 53 LVVEPETSYTIDIMPPNAYRGRDRVINL--PSKFTHLSSNKVKHVIPAIQWTPEGRRLVV 110 L+V S T+D + + +L ++S +V + W+ + + Sbjct: 27 LLVSGTVSGTVD--ANFSTDSSLELWSLLAADSEKPIASLQVDSKFNDLDWSHNNKIIAG 84 Query: 111 ATYSGEFSLW--NASSFTFE--TLMQAHDSAVTTMKYS-HDSDWMISGDADGMIKIWQPN 165 A +G L+ N ++ H S+V T+K++ + + SG +G I IW N Sbjct: 85 ALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMN 144 Query: 166 FSMVKEID---------AAHTESIRDMAFSSNDSK-FVTCSDDNILKIWNFSNGKQERVL 215 + + + + +A++ + + F + N IW+ K+ L Sbjct: 145 KCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHL 204 Query: 216 S------GHHWDVKSCDWHPEMGL---IASASK-DNLVKLWDPRS-GNCISSI-LKFKHT 263 S G + +WHP+ A+ S D + +WD R+ + ++ + Sbjct: 205 SYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNANTPLQTLNQGHQKG 264 Query: 264 VLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLA 323 +L + +LL++ +D + +++ + + ++ P +F A Sbjct: 265 ILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQFPARGNWCFKTKFAPEAPDLFACA 324 Query: 324 CYDGSLKH 331 +D ++ Sbjct: 325 SFDNKIEV 332 Score = 93.7 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 47/342 (13%), Positives = 118/342 (34%), Gaps = 34/342 (9%) Query: 112 TYSGEFSLWNA---SSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSM 168 + LW+ S +Q + +SH++ + +G ++++ N + Sbjct: 42 STDSSLELWSLLAADSEKPIASLQVDSKF-NDLDWSHNNKIIAGALDNGSLELYSTNEAN 100 Query: 169 ----VKEIDAAHTESIRDMAFSS-NDSKFVTCSDDNILKIWNFSNGKQERVLSGHH---- 219 + H+ S++ + F++ D+ + ++ + IW+ + + Sbjct: 101 NAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQ 160 Query: 220 -----WDVKSCDWHPEM-GLIASASKDNLVKLWDPRSGNCISSIL------KFKHTVLKT 267 +V S W+ + + ASA N +WD ++ + + K + Sbjct: 161 SMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVV 220 Query: 268 RFQPTKGNLLMAISK---DKSCRVFDIRYSMKELMCV--RDETDYMTLEWHPINESMFTL 322 + P + + D S ++D+R + L + + ++L+W +E + Sbjct: 221 EWHPKNSTRVATATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLS 280 Query: 323 ACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPV-GHIFATAAKDRTIRFWTRAR 381 + D ++ ++ + L+ A + P +FA A+ D I T Sbjct: 281 SGRDNTVLLWNPE---SAEQLSQFPARGNWCFKTKFAPEAPDLFACASFDNKIEVQTLQN 337 Query: 382 PIDPNAYDDPTYNNKKINGWFFGINNDINAVREKSEFGAAPP 423 + + ++ F+ + + + S F P Sbjct: 338 LTNTLDEQETETKQQESETDFWNNVSREESKEKPSVFHLQAP 379 >6F1U-h nrPDB Length = 612 Score = 105 bits (263), Expect = 3e-23, Method: Composition-based stats. Identities = 62/370 (16%), Positives = 117/370 (31%), Gaps = 50/370 (13%) Query: 95 VIPAIQWTPEGRRLVVATY----------SGEFSLWNASSFTFETLMQAH-DSAVTTM-- 141 V+ + W+ + L+VA+Y G +WN H SAV + Sbjct: 255 VVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATF 314 Query: 142 -KYSHDSDWMISGDADGMIKIWQPNFSMVKEID------AAHTESIRDMAF--SSNDSKF 192 K+ + ++ G G I +W + + AAHT + + + N Sbjct: 315 AKFHP--NLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNL 372 Query: 193 VTCSDDNILKIWNFS-----NGKQERVLSGHHW-DVKSCDWH-PEMGLIASASKDNLVKL 245 ++ S D + W+ E V V S + ++ S++ V Sbjct: 373 ISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYT 432 Query: 246 WDPRSGNCISS---ILKFKHTVLKTRFQPTKGN-----LLMAISKDKSCRVFDIRYSMKE 297 R G+ + + G L + S D + +++ + + Sbjct: 433 -ACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTKNNKPL 491 Query: 298 LMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLS 357 + + W P + ++F G L ++L + P +I + + + Sbjct: 492 YSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVR 551 Query: 358 YNPVGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFFG-INNDINAVREKS 416 + G A + I + I D+ FG +INA R + Sbjct: 552 WTHSGREIAVGDSEGQIVIYDVGEQIAVPRNDEWA---------RFGRTLAEINANRADA 602 Query: 417 EFGAAPPPPA 426 E AA PA Sbjct: 603 EEEAATRIPA 612 Score = 57.8 bits (138), Expect = 9e-09, Method: Composition-based stats. Identities = 29/181 (16%), Positives = 61/181 (33%), Gaps = 26/181 (14%) Query: 219 HWDVKSCDWHPEMGLIASASK----------DNLVKLWDPRSGNCISSILKF-KHTVLKT 267 H V DW + + AS D + +W+ + + + V+ Sbjct: 253 HRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSA 312 Query: 268 RFQPTKGNLLMAISKDKSCRVFDIRYSMKELMC-------VRDETDYMTLEWHPINESMF 320 F NL++ + ++D R + + + Y N Sbjct: 313 TFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNL 372 Query: 321 TLACYDGSLKHFDLLQNLNEPILTIPYAHDK----CITSLSYNPVGHI--FATAAKDRTI 374 DG + + L L+ P ++ H + +TS+S+ PVG + F +++ ++ Sbjct: 373 ISISTDGKICSWSL-DMLSHPQDSMELVHKQSKAVAVTSMSF-PVGDVNNFVVGSEEGSV 430 Query: 375 R 375 Sbjct: 431 Y 431 Score = 57.4 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 24/220 (10%), Positives = 63/220 (28%), Gaps = 29/220 (13%) Query: 9 YQNQNQIQQSQQPPLKKYV---------------TQRRSVDVSSPYINLYYNRRHGLPNL 53 N I S + + Q ++V V+S + + N Sbjct: 367 QNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPV-----GDVNNF 421 Query: 54 VVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATY 113 VV E + G + ++ + A+ ++ V +++ Sbjct: 422 VVGSEEGSVYTACRHGSKAGISEMF--EGHQGPITGIHCHAAVGAVDFSH---LFVTSSF 476 Query: 114 SGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISG-DADGMIKIWQPNFSMV--- 169 LW+ + + + V + +S + + D G + +W N Sbjct: 477 DWTVKLWSTKNNKPLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPT 536 Query: 170 KEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNG 209 I ++ + ++ + + + + I++ Sbjct: 537 ASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQ 576 >5A9Q-7 nrPDB Length = 360 Score = 104 bits (260), Expect = 7e-23, Method: Composition-based stats. Identities = 53/330 (16%), Positives = 104/330 (31%), Gaps = 75/330 (22%) Query: 91 KVKHVIPAIQWTPEGRRLVVATYSGEFSLWN-ASSF--TFETLMQAHDSAVTTMKYSHD- 146 K +I + + GRR+ + +W+ + S + H +V + ++H Sbjct: 10 DHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPE 69 Query: 147 -SDWMISGDADGMIKIWQPNFSMVKEIDAAHTESI------------RDMAFSSN--DSK 191 + S D +W+ + + + D+ F+ Sbjct: 70 FGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLM 129 Query: 192 FVTCSDDNILKIWNFSNGKQERVLS-----GHHWDVKSCDWHPEMG-----LIASASKDN 241 TCS D I++I+ + S W+P +IA S D+ Sbjct: 130 LATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDS 189 Query: 242 ------LVKLW----DPRSGNCISSILKFKHTVLKTRFQPTKGN---LLMAISKDKSCRV 288 V+++ + R +++ V F P G +L +KD R+ Sbjct: 190 SPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKD--VRI 247 Query: 289 FDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYA 348 F ++ KEL P + +A +D Sbjct: 248 FTLKPVRKELTSSGG----------PTKFEIHIVAQFDN--------------------- 276 Query: 349 HDKCITSLSYNPVGHIFATAAKDRTIRFWT 378 H+ + +S+N G + A++ D +R W Sbjct: 277 HNSQVWRVSWNITGTVLASSGDDGCVRLWK 306 Score = 99.8 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 50/250 (20%), Positives = 85/250 (34%), Gaps = 40/250 (16%) Query: 168 MVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSN---GKQERVLSGHHWDVKS 224 + + I A H + I D++F + + TCS D +K+W+ S H V Sbjct: 3 VARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWR 62 Query: 225 CDW-HPE-MGLIASASKDNLVKLWDPRSGNCISSILKFKHT------------VLKTRFQ 270 W HPE ++AS S D +W+ G + H V +F Sbjct: 63 VTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFA 122 Query: 271 PTK-GNLLMAISKDKSCRVFDIRYSMKELMCVRDET-----DYMTLEWHPINES----MF 320 P G +L S D R+++ M + W+P + M Sbjct: 123 PKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMI 182 Query: 321 TLACYDG------SLKHFDLLQNLNE-PILTIPYAHDKCITSLSYNPVG----HIFATAA 369 + D ++ F+ +N + + +++ P HI A A Sbjct: 183 AVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIAT 242 Query: 370 KDRTIRFWTR 379 KD +R +T Sbjct: 243 KD--VRIFTL 250 Score = 40.5 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 17/93 (18%), Positives = 31/93 (33%), Gaps = 21/93 (22%) Query: 92 VKHVIPAIQWTPE-GR---RLVVATYSGEFSLWNASSFTFETLMQA-------------- 133 V + I + P GR L +AT ++ E Sbjct: 218 VTDPVHDIAFAPNLGRSFHILAIATKD--VRIFTLKPVRKELTSSGGPTKFEIHIVAQFD 275 Query: 134 -HDSAVTTMKYSHDSDWMISGDADGMIKIWQPN 165 H+S V + ++ + S DG +++W+ N Sbjct: 276 NHNSQVWRVSWNITGTVLASSGDDGCVRLWKAN 308 Score = 37.4 bits (85), Expect = 0.013, Method: Composition-based stats. Identities = 10/56 (17%), Positives = 25/56 (44%) Query: 343 LTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKI 398 +I H I +S++ G AT + D++++ W ++ D + ++ + Sbjct: 5 RSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSV 60 Score = 32.0 bits (71), Expect = 0.62, Method: Composition-based stats. Identities = 17/118 (14%), Positives = 35/118 (29%), Gaps = 20/118 (16%) Query: 49 GLPNLVVEPETSYTIDIMPPNAYRGRDRVINL------------PSKFT---HLSSNKVK 93 + ++ P + I+ R+ L P+KF + Sbjct: 221 PVHDIAFAPNLGRSFHILAI--ATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHN 278 Query: 94 HVIPAIQWTPEGRRLVVATYSGEFSLWNA---SSFTFETLMQAHDSAVTTMKYSHDSD 148 + + W G L + G LW A ++ +++ + S V S+ Sbjct: 279 SQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPVNGSSQQGTSN 336 >5M89-A nrPDB Length = 329 Score = 101 bits (251), Expect = 7e-22, Method: Composition-based stats. Identities = 40/242 (16%), Positives = 83/242 (34%), Gaps = 11/242 (4%) Query: 142 KYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNIL 201 +++ G DG + I+ + V+ + + +K V + + Sbjct: 58 SLDLENECAAVGGLDGKLDIYSVVANKVERTLDIGE-PVTATEW--TGTKVVIGTAKGWV 114 Query: 202 KIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFK 261 K+++ G++ H V HP ++AS D +D +G ++ + Sbjct: 115 KVYDA--GRESATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGERVA--RGYA 170 Query: 262 HTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFT 321 L T GNL A ++ VF ++++ T L + Sbjct: 171 DAALTTCAFHPDGNLFAAGTQTGHILVFHT-TTLEQAESFPLGTPIQALAFSENGFWFAA 229 Query: 322 LACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDR-TIRFWTRA 380 S+ FDL ++ + + S+S++ G AT T++ +T+A Sbjct: 230 TGKGTSSVTIFDLRKSGAAAAVKELQ--TGEVLSISWDYTGQYLATGGGTGVTVQMYTKA 287 Query: 381 RP 382 Sbjct: 288 TK 289 Score = 96.7 bits (239), Expect = 2e-20, Method: Composition-based stats. Identities = 29/284 (10%), Positives = 85/284 (29%), Gaps = 12/284 (4%) Query: 94 HVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISG 153 +V A E V G+ +++ + E + + VT ++ ++ G Sbjct: 52 NVTQASSLDLENECAAVGGLDGKLDIYSVVANKVERTLDIGE-PVTATEW--TGTKVVIG 108 Query: 154 DADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQER 213 A G +K++ H + +A + D ++ G++ Sbjct: 109 TAKGWVKVYDA--GRESATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGERVA 166 Query: 214 VLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTK 273 + +C +HP+ L A+ ++ + ++ + S + F Sbjct: 167 RGYA-DAALTTCAFHPDGNLFAAGTQTGHILVFHTTTLEQAESF-PLGTPIQALAFSENG 224 Query: 274 GNLLMAISKDKSCRVFDIR-YSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHF 332 S +FD+R + + +++ W + + T +++ + Sbjct: 225 FWFAATGKGTSSVTIFDLRKSGAAAAVKELQTGEVLSISWDYTGQYLATGGGTGVTVQMY 284 Query: 333 DLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRF 376 + + + + + +++ + Sbjct: 285 TKATKSWSEPVRLGM----PVVGVKWGGEAKRLVVVSREGVVSV 324 Score = 88.6 bits (218), Expect = 4e-18, Method: Composition-based stats. Identities = 33/262 (12%), Positives = 86/262 (32%), Gaps = 10/262 (3%) Query: 64 DIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNAS 123 + G+ + ++ + + + A +WT G ++V+ T G +++A Sbjct: 64 ECAAVGGLDGKLDIYSV-VANKVERTLDIGEPVTATEWT--GTKVVIGTAKGWVKVYDA- 119 Query: 124 SFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDM 183 Q H VT + + S D + + ++ Sbjct: 120 -GRESATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETG-ERVARGYADAALTTC 177 Query: 184 AFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKD-NL 242 AF + + F + + +++ + +Q +++ + A+ K + Sbjct: 178 AFHPDGNLFAAGTQTGHILVFHTTTLEQAESFP-LGTPIQALAFSENGFWFAATGKGTSS 236 Query: 243 VKLWDPR-SGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCV 301 V ++D R SG + VL + T L + +++ + + V Sbjct: 237 VTIFDLRKSGAAAAVKELQTGEVLSISWDYTGQYLATGGGTGVTVQMY-TKATKSWSEPV 295 Query: 302 RDETDYMTLEWHPINESMFTLA 323 R + ++W + + ++ Sbjct: 296 RLGMPVVGVKWGGEAKRLVVVS 317 >5CXB-B nrPDB Length = 369 Score = 100 bits (250), Expect = 1e-21, Method: Composition-based stats. Identities = 52/359 (14%), Positives = 103/359 (28%), Gaps = 69/359 (19%) Query: 85 THLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSF--TFETLMQAHDSAVTTMK 142 + + ++ P G L G +W + + + D AV T++ Sbjct: 13 QQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNG-DEAVNTVR 71 Query: 143 YSHDSDWM---ISGDADGMIKI---------WQPNFSMVKEIDAAH-------------- 176 + D + D + I + H Sbjct: 72 WRPTKDTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNGKQQANLPPGK 131 Query: 177 ------------------------TESIRDMAFSSNDSKFVTCSDDN---ILKIWNFSNG 209 +I+ +++ F T S + I S Sbjct: 132 EPPGKWARPGTRLEDEGVLLRITVRSTIKAISWHRRGDHFATVSPSGQRSSVAIHTLSKH 191 Query: 210 KQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRF 269 + + ++ +HP L A++ ++ +D + + + + Sbjct: 192 LTQIPFRKLNGLAQTASFHPLRPLFFVATQ-RSIRCYDLQKLELVKIVQPGAKWISSFDV 250 Query: 270 QPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETD-YMTLEWHPINESMFTLACYDGS 328 P N L+ S DK D+ S + +R T+ + +H +F A DGS Sbjct: 251 HPGGDN-LVVGSYDKRLLWHDLDLSNRPYKTMRFHTEAIRAVRFHKGGLPLFADASDDGS 309 Query: 329 LKHF------DLLQNLNEPILTIPYAHDK----CITSLSYNPVGHIFATAAKDRTIRFW 377 L+ F D L+N + + H + + ++P +A D T R W Sbjct: 310 LQIFHGKVPNDQLENPTIVPVKMLKGHKVVNKLGVLDIDWHPREPWCVSAGADGTARLW 368 Score = 88.6 bits (218), Expect = 5e-18, Method: Composition-based stats. Identities = 50/260 (19%), Positives = 83/260 (31%), Gaps = 23/260 (8%) Query: 3 GHNQNQYQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYT 62 GH N Q N + P K+ R + + L R + + + Sbjct: 116 GHATNGKQQANLPPGKEPP--GKWA--RPGTRLEDEGVLLRITVRSTIKAISWHRRGDHF 171 Query: 63 IDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNA 122 + P R + L T + K+ + + P VAT ++ Sbjct: 172 ATVSPSGQ-RSSVAIHTLSKHLTQIPFRKLNGLAQTASFHPLRPLFFVATQ-RSIRCYDL 229 Query: 123 SSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIW-QPNFS-MVKEIDAAHTESI 180 ++Q +++ D ++ G D + +W + S + HTE+I Sbjct: 230 QKLELVKIVQPGAKWISSFDVHPGGDNLVVGSYDKRL-LWHDLDLSNRPYKTMRFHTEAI 288 Query: 181 RDMAFSSND-SKFVTCSDDNILKIW---------NFSNGKQERVLSGHHW----DVKSCD 226 R + F F SDD L+I+ ++L GH V D Sbjct: 289 RAVRFHKGGLPLFADASDDGSLQIFHGKVPNDQLENPTIVPVKMLKGHKVVNKLGVLDID 348 Query: 227 WHPEMGLIASASKDNLVKLW 246 WHP SA D +LW Sbjct: 349 WHPREPWCVSAGADGTARLW 368 Score = 74.8 bits (182), Expect = 8e-14, Method: Composition-based stats. Identities = 42/312 (13%), Positives = 92/312 (29%), Gaps = 68/312 (21%) Query: 163 QPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQ-ERVLSGHHWD 221 +P ++ + I H +R +A T DD +++W G+Q V Sbjct: 7 KPFPTVQQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEA 66 Query: 222 VKSCDWHPEMGLI---ASASKDNLVKL---------WDPRSGNCISSILKF--------- 260 V + W P A+A +D + + D S + +++ Sbjct: 67 VNTVRWRPTKDTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNGKQQAN 126 Query: 261 -----------------------------KHTVLKTRFQPTKGNLLMAISKDK---SCRV 288 + T+ + +G+ +S S + Sbjct: 127 LPPGKEPPGKWARPGTRLEDEGVLLRITVRSTIKAISWH-RRGDHFATVSPSGQRSSVAI 185 Query: 289 FDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYA 348 + + ++ + T +HP+ S++ +DL ++ I Sbjct: 186 HTLSKHLTQIPFRKLNGLAQTASFHPL--RPLFFVATQRSIRCYDL---QKLELVKIVQP 240 Query: 349 HDKCITSLSYNPVGHIFATAAKDRTIRFWT----RARPIDPNAYDDPTYNNKKINGW--- 401 K I+S +P G + D+ + W RP + + + Sbjct: 241 GAKWISSFDVHPGGDNLVVGSYDKRL-LWHDLDLSNRPYKTMRFHTEAIRAVRFHKGGLP 299 Query: 402 FFGINNDINAVR 413 F +D +++ Sbjct: 300 LFADASDDGSLQ 311 >5A9Q-0 nrPDB Length = 380 Score = 98.7 bits (244), Expect = 4e-21, Method: Composition-based stats. Identities = 35/167 (20%), Positives = 73/167 (43%), Gaps = 8/167 (4%) Query: 146 DSDWMISGDADGMIKIWQPNFS-MVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIW 204 ++ +++ DG I +++ + V+ ID A + ++ + F + +T + LKIW Sbjct: 140 NNPEIVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRT-PEILTVNSIGQLKIW 198 Query: 205 NFS----NGKQERVLSGHHWDVKSCDWHPEM-GLIASASKDNLVKLWDPRSGN-CISSIL 258 +F Q L+G + D HP ++A+ +D ++ +WD R G +S + Sbjct: 199 DFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLK 258 Query: 259 KFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDET 305 + + + F P+ L S+D S +D + E + + Sbjct: 259 AHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQG 305 Score = 79.8 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 36/274 (13%), Positives = 85/274 (31%), Gaps = 40/274 (14%) Query: 145 HDSDWMISGDADGM---IKIWQPNFSMVKEIDAA------------HTESIRDMAFSSND 189 ++ +G D I +W + D H + D+ F + Sbjct: 27 QTAETFATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCDIRHHGDVMDLQF-FDQ 85 Query: 190 SKFVTCSDDNILKIW-------NFSNGKQERVLSGHHWDVK-------SCDWHPEMGLIA 235 + V S + ++ S +Q H I Sbjct: 86 ERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTGVVCNNPEIV 145 Query: 236 SASKDNLVKLWDPRSGNCISSI-LKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYS 294 + +D + L+ + +I T+ F + ++ ++ +++D R Sbjct: 146 TVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFL--RTPEILTVNSIGQLKIWDFRQQ 203 Query: 295 MKELMCV----RDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHD 350 E + D ++ HP + + DG L +D+ Q +++ AH+ Sbjct: 204 GNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGT--MPVSLLKAHE 261 Query: 351 KCITSLSYNP-VGHIFATAAKDRTIRFWTRARPI 383 + + ++P T ++D ++ W + + Sbjct: 262 AEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDV 295 Score = 79.4 bits (194), Expect = 3e-15, Method: Composition-based stats. Identities = 39/275 (14%), Positives = 92/275 (33%), Gaps = 35/275 (12%) Query: 108 LVVATYSGE---FSLW---NASSFTFETLMQA---------HDSAVTTMKYSHDSDWMIS 152 ++ E SLW + + + + H V +++ D + +++ Sbjct: 32 FATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCDIRHHGDVMDLQF-FDQERIVA 90 Query: 153 GDADGMIKIW-----QPNFSMVKEIDAAHTE---------SIRDMAFSSNDSKFVTCSDD 198 + G + ++ S+ ++ AH S N+ + VT +D Sbjct: 91 ASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTGVVCNNPEIVTVGED 150 Query: 199 NILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSG----NCI 254 + ++ + + R + I + + +K+WD R + I Sbjct: 151 GRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSIGQLKIWDFRQQGNEPSQI 210 Query: 255 SSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYM-TLEWH 313 S+ + + P + +++ +D ++D+R + ++ M + +H Sbjct: 211 LSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVHFH 270 Query: 314 PINESMFTLACYDGSLKHFDLLQNLNEPILTIPYA 348 P N DGSL H+D ++ E Sbjct: 271 PSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQG 305 Score = 49.4 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 37/240 (15%), Positives = 72/240 (30%), Gaps = 33/240 (13%) Query: 192 FVTCSDDN---ILKIW---NFSNGKQERVLSG---------HHWDVKSCDWHPEMGLIAS 236 F T S DN + +W +F N + G HH DV + + ++A+ Sbjct: 32 FATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCDIRHHGDVMDLQFFDQERIVAA 91 Query: 237 ASKDNLVKLWDPRSGNCISS----ILKFKHT---VLKTRFQPTKGNLL-----MAISKDK 284 +S + + +S HT P G + + + +D Sbjct: 92 SSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTGVVCNNPEIVTVGEDG 151 Query: 285 SCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEP-IL 343 +F + ++ + + T+ G LK +D Q NEP + Sbjct: 152 RINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSI-GQLKIWDFRQQGNEPSQI 210 Query: 344 TIPYAHDKCITSLSYNPVGHIF-ATAAKDRTIRFWTRAR---PIDPNAYDDPTYNNKKIN 399 + + +P AT +D + W + P+ + + Sbjct: 211 LSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVHFH 270 Score = 37.0 bits (84), Expect = 0.019, Method: Composition-based stats. Identities = 18/119 (15%), Positives = 37/119 (31%), Gaps = 7/119 (5%) Query: 21 PPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINL 80 LK + +++ + S I R L + P + + G + ++ Sbjct: 193 GQLKIWDFRQQGNEPSQ--ILSLTGDRVPLHCVDRHPNQQHVV---ATGGQDGMLSIWDV 247 Query: 81 PSKFTHLSSNK-VKHVIPAIQWTPEG-RRLVVATYSGEFSLWNASSFTFETLMQAHDSA 137 +S K + + + + P L + G W+AS+ E H Sbjct: 248 RQGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQGG 306 >3W15-A nrPDB Length = 368 Score = 98.7 bits (244), Expect = 4e-21, Method: Composition-based stats. Identities = 56/352 (15%), Positives = 112/352 (31%), Gaps = 70/352 (19%) Query: 97 PAIQWTPE-GRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTT---------MKYSHD 146 +Q++P RL VA S + N F E V + + ++ Sbjct: 14 YGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQDCLFDLAWNES 73 Query: 147 S-DWMISGDADGMIKIWQPNFS-MVKEIDAAHTESIRDMAFS-SNDSKFVTCSDDNILKI 203 + ++ DG ++++ F I H + ++ N F++ S D +KI Sbjct: 74 HENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKI 133 Query: 204 WNFSNGKQERVLSGHH---------------------------WDVKSCDWHP-EMGLIA 235 W+ + L+ V + P + L+ Sbjct: 134 WSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVL 193 Query: 236 SASKDNLVKLWDPR--SGNCISSILKFKH-TVLKTRFQPTKGNLLMAISKDKSCRVFDIR 292 S S ++ L+D R SG ++ L L F + ++ D + R++DIR Sbjct: 194 SCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIR 253 Query: 293 YSMKELMCVRDETDYM-----------TLEWHPINESMFTLACYDGSLKHF-DLLQNLNE 340 K + + + + W P + ++ A YD + + + DL + + Sbjct: 254 MLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAK 313 Query: 341 PILTI------------PYAHDKCITSLSYNPVGH--IFATAAKDRTIRFWT 378 H + + ++ G A+ A D + W Sbjct: 314 ETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 365 Score = 83.3 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 49/278 (17%), Positives = 96/278 (34%), Gaps = 60/278 (21%) Query: 5 NQNQYQNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTID 64 N N QN + S +K + R+ + + P Sbjct: 113 NWNLVNRQNFLSSSWDGSIKIWSPLRK------------------QSLMTLTPR-----P 149 Query: 65 IMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTP-EGRRLVVATYSGEFSLWN-- 121 + + +I FT +S K ++ + Q++P + ++ + + SL++ Sbjct: 150 LEITKMVDPLNAIILKKKSFTGIS--KNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIR 207 Query: 122 ASSFTFETLMQAHDS-AVTTMKYSHDSDW-MISGDADGMIKIWQ-----------PNFSM 168 S + H T ++ + + +G D I+IW N S Sbjct: 208 LPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSC 267 Query: 169 VKEIDAAHTESIRDMAFSS-NDSKFVTCSDDNILKIW-NFSNGKQERV------------ 214 + EI AH +IR + +S + + ++ S D +IW + SN + Sbjct: 268 INEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGS 327 Query: 215 ---LSGHHWDVKSCDWH--PEMGLIASASKDNLVKLWD 247 + H V DW + G +AS + D + +W+ Sbjct: 328 IFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 365 >3EI3-B nrPDB Length = 383 Score = 97.5 bits (241), Expect = 1e-20, Method: Composition-based stats. Identities = 56/327 (17%), Positives = 119/327 (36%), Gaps = 31/327 (9%) Query: 79 NLPSKFTHLSSNKVKHVIPAIQWTPEG-RRLVVATYSGEFSLWNASSFTFETLMQA--HD 135 +L S H +++ + +++W P + V + G+ LW+ + +Q Sbjct: 59 SLKSYKLHRTASPFDRRVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPG 118 Query: 136 SAVTTMKYSH-DSDWMISGDADGMIKIWQPNFSMVKEIDAAHT--ESIRDMAFSSNDSKF 192 A+T MK++ +++ + G + + S+++ + + S + Sbjct: 119 DAITGMKFNQFNTNQLFVSSIRGATTLRDFSGSVIQVFAKTDSWDYWYCCVDVSVSRQML 178 Query: 193 VTCSDDNILKIWNFSNGKQERVLSG--HHWDVKSCDWHPEMG-LIASASKDNLVKLWDPR 249 T D+ ++ + H V +++P L+A++S D VKLWD R Sbjct: 179 ATG--DSTGRL-LLLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLR 235 Query: 250 S---GNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDI-RYSMKELMCVRDET 305 + N + + + V F PT L+ + RV+ +S + + + Sbjct: 236 NIKDKNSYIAEMPHEKPVNAAYFNPTDSTKLLTTDQRNEIRVYSSYDWSKPDQIIIHPHR 295 Query: 306 DY-----MTLEWHPINESMFTLACYDG--------SLKHFDLLQNLNEPILTIPYAHDKC 352 + + WHP+ + + D ++ +D L P A Sbjct: 296 QFQHLTPIKATWHPMYDLIVAGRYPDDQLLLNDKRTIDIYDANSGGLVHQLRDPNA-AGI 354 Query: 353 ITSLSYNPVGHIFATAAKDRTIRFWTR 379 I+ ++P G + A+ I W R Sbjct: 355 ISLNKFSPTGDVLASG-MGFNILIWNR 380 Score = 66.3 bits (160), Expect = 3e-11, Method: Composition-based stats. Identities = 49/239 (20%), Positives = 84/239 (35%), Gaps = 15/239 (6%) Query: 205 NFSNGKQERVLSGHHWDVKSCDWHP-EMGLIASASKDNLVKLWD--PRSGNCISSILKFK 261 + + K R S V S +WHP +A SK + LWD ++ + Sbjct: 59 SLKSYKLHRTASPFDRRVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPG 118 Query: 262 HTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFT 321 + +F N L S + + D S+ ++ D DY ++ S Sbjct: 119 DAITGMKFNQFNTNQLFVSSIRGATTLRDFSGSVIQVFAKTDSWDYWYCCVD-VSVSRQM 177 Query: 322 LACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIF-ATAAKDRTIRFWTRA 380 LA D + + L + +E + H +T +NP AT++ D T++ W Sbjct: 178 LATGDSTGRLLLLGLDGHE--IFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLR 235 Query: 381 RPIDPNAY-----DDPTYNNKKIN---GWFFGINNDINAVREKSEFGAAPPPPATLEPH 431 D N+Y + N N + N +R S + + P + PH Sbjct: 236 NIKDKNSYIAEMPHEKPVNAAYFNPTDSTKLLTTDQRNEIRVYSSYDWSKPDQIIIHPH 294 Score = 65.5 bits (158), Expect = 5e-11, Method: Composition-based stats. Identities = 27/225 (12%), Positives = 69/225 (30%), Gaps = 9/225 (4%) Query: 161 IWQPNFSMVKEIDAAHTESIRDMAFSSNDSK-FVTCSDDNILKIWNFSNGKQERVLSG-- 217 I + + + + + S + +W++ + + G Sbjct: 57 IRSLKSYKLHRTASPFDRRVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMG 116 Query: 218 HHWDVKSCDWHP--EMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGN 275 + ++ L S+ + SG+ I K + Sbjct: 117 PGDAITGMKFNQFNTNQLFVSSIRGATTL--RDFSGSVIQVFAKTDSWDYWYCCVDVSVS 174 Query: 276 LLMAISKDKSCRVFDIRYSMKELMCVR-DETDYMTLEWHPINESMFTLACYDGSLKHFDL 334 M + D + R+ + E+ + + E++P + + + D ++K +DL Sbjct: 175 RQMLATGDSTGRLLLLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDL 234 Query: 335 LQNLNEPILTIPYAHDKCITSLSYNP-VGHIFATAAKDRTIRFWT 378 ++ H+K + + +NP T + IR ++ Sbjct: 235 RNIKDKNSYIAEMPHEKPVNAAYFNPTDSTKLLTTDQRNEIRVYS 279 >6BX3-B nrPDB Length = 412 Score = 96.7 bits (239), Expect = 2e-20, Method: Composition-based stats. Identities = 48/339 (14%), Positives = 110/339 (32%), Gaps = 46/339 (13%) Query: 81 PSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFE----TLMQAHDS 136 P K TH N ++ +Q++P G L + +G +++ +F ++ AH Sbjct: 15 PEKLTHTIENPLRT--ECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVR 72 Query: 137 AVTTMKYSHDSDWMISGDADGMIKIWQPN--FSMVKEIDAAHTESIRDMAFSSNDSKFVT 194 +T++ +S D +++ D IK+W + +KEI I + + Sbjct: 73 PITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRF--DSPIWGCQWLDAKRRLCV 130 Query: 195 C-------------SDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDN 241 S+D + + + S+ KQ H V C H + I Sbjct: 131 ATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDH-GYVLVCTVHTKHPNIIIVG--- 186 Query: 242 LVKLW-------DPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYS 294 K W CI S+ + G L D++ R ++I Sbjct: 187 TSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVS-QNGERLAINCSDRTIRQYEISID 245 Query: 295 ----------MKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILT 344 + V ++ + + + + + S + + + ++ Sbjct: 246 DENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVR 305 Query: 345 IPYAHDKCITSLSYNPVGHIFATAA-KDRTIRFWTRARP 382 + ++ + ++++ + + + W+ P Sbjct: 306 VLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSVVIP 344 Score = 65.5 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 21/96 (21%), Positives = 46/96 (47%), Gaps = 2/96 (2%) Query: 292 RYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPIL-TIPYAHD 350 + K + + L++ P + L C +G+L +D+ + + AH Sbjct: 13 EHPEKLTHTIENPLRTECLQFSPCGDY-LALGCANGALVIYDMDTFRPICVPGNMLGAHV 71 Query: 351 KCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPN 386 + ITS++++P G + T+++D +I+ W ++P P Sbjct: 72 RPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPL 107 Score = 60.5 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 38/278 (13%), Positives = 89/278 (32%), Gaps = 38/278 (13%) Query: 46 RRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEG 105 + ++ P+ + + ++ +L L + I QW Sbjct: 70 HVRPITSIAWSPDGRLLLTSSRDWS----IKLWDLSKPSKPLKEIRFDSPIWGCQWLDAK 125 Query: 106 RRLVVAT--YSGEFSLWNASSFTFETLMQAHDSA------------VTTMKYSHDSDWMI 151 RRL VAT + + + S+ +L+ D V T+ H + +I Sbjct: 126 RRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHP-NIII 184 Query: 152 SGDADGMIKIW---QPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFS- 207 G + G + + + + +I+ + S N + D ++ + S Sbjct: 185 VGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISI 244 Query: 208 ---NGKQERVLSGHHW-------DVKSCDWHPEMG--LIAS--ASKDNLVKLWDPRSGNC 253 N E L H + + L+AS S + + +W+ SG Sbjct: 245 DDENSAVELTLE-HKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTL 303 Query: 254 ISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDI 291 + + + ++ + +++ + + V+ + Sbjct: 304 VRVLEGAEEELIDINWDFYSMSIVSNGFESGNVYVWSV 341 >5WLC-LN nrPDB Length = 776 Score = 96.7 bits (239), Expect = 2e-20, Method: Composition-based stats. Identities = 45/320 (14%), Positives = 105/320 (32%), Gaps = 31/320 (9%) Query: 78 INLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSF--TFET--LMQA 133 +L + + + VI +I +L V +G L + S E ++ Sbjct: 126 WDLATGLPLRNYDCNSGVIWSISINDSQDKLSVGCDNGTVVLIDISGGPGVLEHDTILMR 185 Query: 134 HDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESI----------RDM 183 ++ V T+ + D D++I G +DG I+IW + HT + + Sbjct: 186 QEARVLTLAWKKD-DFVIGGCSDGRIRIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSV 244 Query: 184 AFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLV 243 + + + +K W+F + H DV + + SA D + Sbjct: 245 IYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAHDADVLCLTTDTDNNYVFSAGVDRKI 304 Query: 244 KLWDPRSGNC--------ISSILKFKHTVLKTR-FQPTKGNLLMAISKDKSCRVFDI-RY 293 + + S+ L + + +Q + L++ +K+ + + + Sbjct: 305 FQFSQNTNKSQKNNRWVNSSNRLLHGNDIRAICAYQSKGADFLVSGGVEKTLVINSLTSF 364 Query: 294 SMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEP-----ILTIPYA 348 S + Y + + ++K + + + + + + Sbjct: 365 SNGNYRKMPTVEPYSKNVLVNKEQRLVVSWSE-STVKIWTMGTDSSTEQNYKLVCKLTLK 423 Query: 349 HDKCITSLSYNPVGHIFATA 368 D+ I++ S +P G + Sbjct: 424 DDQNISTCSLSPDGQVLVVG 443 Score = 94.8 bits (234), Expect = 7e-20, Method: Composition-based stats. Identities = 47/344 (13%), Positives = 96/344 (27%), Gaps = 32/344 (9%) Query: 66 MPPNAYRGRDRVINLPSKFTH--LSSNKVKHVIPAIQWTP---EGRRLVVATYSGEFSLW 120 + G + N + + + I + W+ E RL S + W Sbjct: 67 LAIGRSNGNIEIWNPRNNWFQEMVIEGGKDRSIEGLCWSNVNGESLRLFSIGGSTVVTEW 126 Query: 121 NASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFS----MVKEIDAAH 176 + ++ + + ++ + D + G +G + + + I Sbjct: 127 DLATGLPLRNYDCNSGVIWSISINDSQDKLSVGCDNGTVVLIDISGGPGVLEHDTILMRQ 186 Query: 177 TESIRDMAFSSNDSKFVTCSDDNILKIWNFSN-----GKQERVLSGHHWD-----VKSCD 226 + +A+ +D CS D ++IW+ G+ + V S Sbjct: 187 EARVLTLAWKKDDFVIGGCS-DGRIRIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVI 245 Query: 227 WHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSC 286 + P IAS +K WD + S VL T N + + D+ Sbjct: 246 YLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAHDADVLCLTTD-TDNNYVFSAGVDRKI 304 Query: 287 RVFDIRYSM--------KELMCVRDETDYMTL-EWHPINESMFTLACYDGSLKHFDLLQN 337 F + + D + + + +L L Sbjct: 305 FQFSQNTNKSQKNNRWVNSSNRLLHGNDIRAICAYQSKGADFLVSGGVEKTLVINSLTSF 364 Query: 338 LNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRAR 381 N +P L N + + ++ T++ WT Sbjct: 365 SNGNYRKMPTVEPYSKNVL-VNKEQRLVVSWSE-STVKIWTMGT 406 Score = 93.7 bits (231), Expect = 2e-19, Method: Composition-based stats. Identities = 54/341 (15%), Positives = 125/341 (36%), Gaps = 38/341 (11%) Query: 99 IQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGM 158 ++ T + R +V + + T +L +H S + K + + G ++G Sbjct: 23 VKMTSQERMIV-----HRCRFVDFTPATITSLAFSHKSNIN--KLTPSDLRLAIGRSNGN 75 Query: 159 IKIWQPNFSMVKE--IDAAHTESIRDMAFSS---NDSKFVTCSDDNILKIWNFSNGKQER 213 I+IW P + +E I+ SI + +S+ + + ++ W+ + G R Sbjct: 76 IEIWNPRNNWFQEMVIEGGKDRSIEGLCWSNVNGESLRLFSIGGSTVVTEWDLATGLPLR 135 Query: 214 VLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCI----SSILKFKHTVLKTRF 269 + + S + ++ + V L D G + + +++ + VL + Sbjct: 136 NYDCNSGVIWSISINDSQDKLSVGCDNGTVVLIDISGGPGVLEHDTILMRQEARVLTLAW 195 Query: 270 QPTKGNLLMAISKDKSCRVFDIR----------YSMKELMCVRDETDYMTLEWHPINESM 319 K + ++ D R++ + ++MK ++ T ++ + P + Sbjct: 196 --KKDDFVIGGCSDGRIRIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTD-Q 252 Query: 320 FTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTR 379 GS+K +D + AHD + L+ + + +A DR + + Sbjct: 253 IASGDSTGSIKFWDFQFAT---LNQSFKAHDADVLCLTTDTDNNYVFSAGVDR--KIFQF 307 Query: 380 ARPIDPNAYDDPTYNNKKINGWFFGINNDINAVREKSEFGA 420 ++ + + ++ N+ NDI A+ GA Sbjct: 308 SQNTNKSQKNNRWVNSSN----RLLHGNDIRAICAYQSKGA 344 Score = 74.8 bits (182), Expect = 7e-14, Method: Composition-based stats. Identities = 46/311 (14%), Positives = 94/311 (30%), Gaps = 35/311 (11%) Query: 64 DIMPPNAYRGRDRVINL------PSKFTHLSSNKVKHVIPAIQWT----PEGRRLVVATY 113 D + GR R+ + + H + W+ P ++ Sbjct: 199 DFVIGGCSDGRIRIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDS 258 Query: 114 SGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVK--- 170 +G W+ T +AHD+ V + D++++ S D I + N + + Sbjct: 259 TGSIKFWDFQFATLNQSFKAHDADVLCLTTDTDNNYVFSAGVDRKIFQFSQNTNKSQKNN 318 Query: 171 -----EIDAAHTESIRDMAF--SSNDSKFVTCSDDNILKIWNFS--NGKQERVLSGHHWD 221 H IR + S V+ + L I + + + R + Sbjct: 319 RWVNSSNRLLHGNDIRAICAYQSKGADFLVSGGVEKTLVINSLTSFSNGNYRKMPTVEPY 378 Query: 222 VKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISS--------ILKFKHTVLKTRFQPTK 273 K+ + E L+ S S+ + VK+W + + LK + P Sbjct: 379 SKNVLVNKEQRLVVSWSE-STVKIWTMGTDSSTEQNYKLVCKLTLKDDQNISTCSLSPDG 437 Query: 274 GNLLMAISKDKSCRVFDIRYSMKELMCVRDE---TDYMTLEWHPINESMFTLACYDGSLK 330 L++ + ++ + ++ L N + +C D + Sbjct: 438 QVLVVGRPSTTKVFHLQPVGNKLKVTKLDNDLLLRTSTKLVKFIDNSKIVICSCEDD-VF 496 Query: 331 HFDLLQNLNEP 341 DL +E Sbjct: 497 IVDLESEEDEK 507 >4E5Z-B nrPDB Length = 436 Score = 96.7 bits (239), Expect = 2e-20, Method: Composition-based stats. Identities = 51/341 (14%), Positives = 111/341 (32%), Gaps = 58/341 (17%) Query: 64 DIMPPNAYRGRDRVIN--LPSKFTHLSSNKVKHVIPAIQWTP-EGRRLVVATYSGEFSLW 120 + + G + N + K T + I +++ P + ++ G L Sbjct: 133 STVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQ 192 Query: 121 NASSFTFETLMQAHDSAVT--TMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTE 178 + + + ++ S S +++GD G + + + H + Sbjct: 193 DFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMD-GKELWNLRMHKK 251 Query: 179 SIRDMAFSSNDSKFV-TCSDDNILKIWNFSNGKQERVLSG---HHWDVKSCDWHPEMGLI 234 + +A + F+ T S D +KIW+ + + H V + + P+ + Sbjct: 252 KVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARL 311 Query: 235 ASASKDNLVKL-----WDPRSGNCISSILKFKH-TVLKTRFQPTKGNLLMAISKD---KS 285 + + + +++ WD G F+H T +K + P +++ D KS Sbjct: 312 LTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKS 371 Query: 286 CRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTI 345 C +++R ++ FD N + + + Sbjct: 372 CTPYELR-----------------------------------TIDVFD--GNSGKMMCQL 394 Query: 346 PYAHDKCITSL-SYNPVGHIFATAAKDRTIRFWTRARPIDP 385 I+SL +NP+G A+A I W+ Sbjct: 395 YDPESSGISSLNEFNPMGDTLASA-MGYHILIWSEQEEART 434 Score = 79.8 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 25/222 (11%), Positives = 67/222 (30%), Gaps = 4/222 (1%) Query: 164 PNFSMVKEIDAAHTESIRDMAFSSND-SKFVTCSDDNILKIWNFSNGKQERVLSG--HHW 220 + + + A +A+ S S + +WNF + + G Sbjct: 106 LDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGG 165 Query: 221 DVKSCDWHP-EMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMA 279 + ++P ++S + +L D + + + + ++ Sbjct: 166 SITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVV 225 Query: 280 ISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLN 339 + + + + + +P + A D ++K +DL Q Sbjct: 226 TGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRG 285 Query: 340 EPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRAR 381 + H + + ++P G T + IR ++ ++ Sbjct: 286 KASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQ 327 Score = 54.4 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 23/192 (11%), Positives = 62/192 (32%), Gaps = 29/192 (15%) Query: 46 RRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPS---KFTHLSSNKVKHVIPAIQWT 102 + + ++ + P + + + ++ +L K + L S +H + A ++ Sbjct: 249 HKKKVTHVALNPCCDWFL---ATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFS 305 Query: 103 PEGRRLVVATYSGEFSL-----WNASSFTFETLMQA--HDSAVTTMKYSHDSDWMISGDA 155 P+G RL+ E + W+ + H + + + + ++ G Sbjct: 306 PDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKA-AWHPRYNLIVVGRY 364 Query: 156 -D-----------GMIKIWQPNFSMVK-EIDAAHTESIRDM-AFSSNDSKFVTCSDDNIL 201 D I ++ N + ++ + I + F+ + + Sbjct: 365 PDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASA-MGYHI 423 Query: 202 KIWNFSNGKQER 213 IW+ + R Sbjct: 424 LIWSEQEEARTR 435 >5WLC-SG nrPDB Length = 573 Score = 94.8 bits (234), Expect = 8e-20, Method: Composition-based stats. Identities = 45/321 (14%), Positives = 97/321 (30%), Gaps = 27/321 (8%) Query: 70 AYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFET 129 +G + I ++ I + +P+G+ +V + +W+ S + Sbjct: 213 YAKGGAKYIPTSKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVK 272 Query: 130 LMQA--HDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSS 187 ++ V ++ + +SD + + AD I+ + N EI H + + D++ + Sbjct: 273 VIPTKDRRGEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALA 332 Query: 188 NDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSC-DWHPEMGLIASASKDNLVKLW 246 + + D +W + G K W E A +D VK Sbjct: 333 MERCVTVGARDRTAMLWKIP-DETRLTFRGGDEPQKLLRRWMKEN---AKEGEDGEVKYP 388 Query: 247 DPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETD 306 D S + V + S + + ++ + Sbjct: 389 D-ESEAPLFFCEGSIDVVSMV-----DDFHFITGSDNGNICLWSLAKKKPIFTERIAHGI 442 Query: 307 YMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFA 366 P D L+ Q + +L ITSL P ++F Sbjct: 443 L------PEPSFNDISGETDEELRK---RQLQGKKLLQPF-----WITSLYAIPYSNVFI 488 Query: 367 TAAKDRTIRFWTRARPIDPNA 387 + + +++ W + + Sbjct: 489 SGSWSGSLKVWKISDNLRSFE 509 Score = 65.9 bits (159), Expect = 4e-11, Method: Composition-based stats. Identities = 42/335 (12%), Positives = 100/335 (29%), Gaps = 34/335 (10%) Query: 53 LVVEPETSYTIDIMPPNAYRGRDRVINLPSK--FTHLSSNKVKHVIPAIQWTPEGRRLVV 110 + P+ Y + + V + S + + + + ++ + +L Sbjct: 242 VAASPDGKYVVT----GGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRKNSDQLYA 297 Query: 111 ATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVK 170 + + ++ + F+ ++ H V + + G D +W+ Sbjct: 298 SCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGARDRTAMLWKIPDETRL 357 Query: 171 EIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPE 230 + ++K +D +K + S L + + Sbjct: 358 TFRGGDEPQKLLRRWMKENAK---EGEDGEVKYPDESEAP----LFFCEGSIDVVSMVDD 410 Query: 231 MGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFD 290 + S + + LW I + + H +L P ++ D+ + Sbjct: 411 FH-FITGSDNGNICLWSLAKKKPIFT-ERIAHGIL-----PEPSFNDISGETDE-----E 458 Query: 291 IRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNE-PILTIPYAH 349 +R + + +L P + +F + GSLK + + NL +L Sbjct: 459 LRKRQLQGKKLLQPFWITSLYAIPYSN-VFISGSWSGSLKVWKISDNLRSFELLGELSGA 517 Query: 350 DKCITSLSYNPVGH-------IFATAAKDRTIRFW 377 +T + G I A+ AK+ + W Sbjct: 518 KGVVTKIQVVESGKHGKEKFRILASIAKEHRLGRW 552 >4J0X-A nrPDB Length = 451 Score = 94.8 bits (234), Expect = 8e-20, Method: Composition-based stats. Identities = 45/321 (14%), Positives = 97/321 (30%), Gaps = 27/321 (8%) Query: 70 AYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFET 129 +G + I ++ I + +P+G+ +V + +W+ S + Sbjct: 91 YAKGGAKYIPTSKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVK 150 Query: 130 LMQA--HDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSS 187 ++ V ++ + +SD + + AD I+ + N EI H + + D++ + Sbjct: 151 VIPTKDRRGEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALA 210 Query: 188 NDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSC-DWHPEMGLIASASKDNLVKLW 246 + + D +W + G K W E A +D VK Sbjct: 211 MERCVTVGARDRTAMLWKIP-DETRLTFRGGDEPQKLLRRWMKEN---AKEGEDGEVKYP 266 Query: 247 DPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETD 306 D S + V + S + + ++ + Sbjct: 267 D-ESEAPLFFCEGSIDVVSMV-----DDFHFITGSDNGNICLWSLAKKKPIFTERIAHGI 320 Query: 307 YMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFA 366 P D L+ Q + +L ITSL P ++F Sbjct: 321 L------PEPSFNDISGETDEELRK---RQLQGKKLLQPF-----WITSLYAIPYSNVFI 366 Query: 367 TAAKDRTIRFWTRARPIDPNA 387 + + +++ W + + Sbjct: 367 SGSWSGSLKVWKISDNLRSFE 387 Score = 65.9 bits (159), Expect = 4e-11, Method: Composition-based stats. Identities = 42/335 (12%), Positives = 100/335 (29%), Gaps = 34/335 (10%) Query: 53 LVVEPETSYTIDIMPPNAYRGRDRVINLPSK--FTHLSSNKVKHVIPAIQWTPEGRRLVV 110 + P+ Y + + V + S + + + + ++ + +L Sbjct: 120 VAASPDGKYVVT----GGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRKNSDQLYA 175 Query: 111 ATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVK 170 + + ++ + F+ ++ H V + + G D +W+ Sbjct: 176 SCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGARDRTAMLWKIPDETRL 235 Query: 171 EIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPE 230 + ++K +D +K + S L + + Sbjct: 236 TFRGGDEPQKLLRRWMKENAK---EGEDGEVKYPDESEAP----LFFCEGSIDVVSMVDD 288 Query: 231 MGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFD 290 + S + + LW I + + H +L P ++ D+ + Sbjct: 289 FH-FITGSDNGNICLWSLAKKKPIFT-ERIAHGIL-----PEPSFNDISGETDE-----E 336 Query: 291 IRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNE-PILTIPYAH 349 +R + + +L P + +F + GSLK + + NL +L Sbjct: 337 LRKRQLQGKKLLQPFWITSLYAIPYSN-VFISGSWSGSLKVWKISDNLRSFELLGELSGA 395 Query: 350 DKCITSLSYNPVGH-------IFATAAKDRTIRFW 377 +T + G I A+ AK+ + W Sbjct: 396 KGVVTKIQVVESGKHGKEKFRILASIAKEHRLGRW 430 >6C0F-s nrPDB Length = 807 Score = 93.7 bits (231), Expect = 2e-19, Method: Composition-based stats. Identities = 57/378 (15%), Positives = 127/378 (33%), Gaps = 57/378 (15%) Query: 39 YINLYYNRRHGLPNLVVEPETSYTIDIMP-PNAYRGRDRVINLPSKFTHLSSNKVKHVIP 97 ++LY R L ++P + I +P P R P + + + K + Sbjct: 391 SLDLYLAPRVRKNKLNIDPNS--LIPELPSPKDLR------PFPIRCSTI-YAGHKGKVR 441 Query: 98 AIQWTPEGRRLVVATYSGEFSLWNASSF------TFETLMQAHDSAVTTMKYSHDSD--W 149 + P G L + G +W + T + D + ++++ D++ Sbjct: 442 TLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGI 501 Query: 150 MISGDADGMIKI------WQPNFSMVKEIDAA----HTESI--RDMAFSSNDSKFVTCSD 197 + + + I + + +I+ ++ ++ + N + Sbjct: 502 LAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGD----GDE 557 Query: 198 D-----------NILKIWNFSNGKQER----VLSGHHWDVKSCDWHPEMGLIASASKDN- 241 D + WN + KQ + VK WH + + D+ Sbjct: 558 DGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQPDSG 617 Query: 242 --LVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELM 299 V + S K K ++ +F P K L + + R++D+ + Sbjct: 618 NTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFV--CSQRYVRIYDLSQQILVKK 675 Query: 300 CVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYN 359 + ++ HP +++ +D + DL +L H+K + S++++ Sbjct: 676 LLPGARWLSKIDIHPRGDNLIAS-SFDKRVLWHDL--DLASTPYKTLRYHEKAVRSVNFH 732 Query: 360 PVGHIFATAAKDRTIRFW 377 +F++AA D TI + Sbjct: 733 KKLPLFSSAADDGTIHVF 750 Score = 92.1 bits (227), Expect = 5e-19, Method: Composition-based stats. Identities = 62/364 (17%), Positives = 120/364 (32%), Gaps = 58/364 (15%) Query: 66 MPPNAYRGRDRVINLPSKFTH------LSSNKVKHVIPAIQWTPEGRRLVVATYSGE-FS 118 + + G RV + + + I I+W P+ ++A GE Sbjct: 452 LATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIH 511 Query: 119 L-------WNASSFTFETLMQA------HDSAVTTMKYSHDSDWMISGDADG-------- 157 L ++ + + + ++ + + D GD DG Sbjct: 512 LIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGD----GDEDGENESAKNA 567 Query: 158 ---MIKIWQPNFSMVKE----IDAAHTESIRDMAFSSNDSKFVTC---SDDNILKIWNFS 207 + W E I + ++++ +++ FVT S + + I S Sbjct: 568 VKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVS 627 Query: 208 NGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKT 267 + + +HP + S+ V+++D + +L + K Sbjct: 628 KHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKI 686 Query: 268 RFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVR-DETDYMTLEWHPINESMFTLACYD 326 P NL+ + S DK D+ + +R E ++ +H +F+ A D Sbjct: 687 DIHPRGDNLIAS-SFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFH-KKLPLFSSAADD 744 Query: 327 GSLKHF------DLLQNLNEPILTIPYAHDKCITSLS-----YNPVGHIFATAAKDRTIR 375 G++ F D+++N L H K I SL ++P +A D T R Sbjct: 745 GTIHVFHATVYDDMMKNPMIVPLKKLTGH-KVINSLGVLDAIWHPREAWLFSAGADNTAR 803 Query: 376 FWTR 379 WT Sbjct: 804 LWTT 807 Score = 91.0 bits (224), Expect = 1e-18, Method: Composition-based stats. Identities = 50/377 (13%), Positives = 103/377 (27%), Gaps = 49/377 (12%) Query: 1 MDGHNQNQY------QNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNR-------- 46 GH S ++ + + I+ N Sbjct: 433 YAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIE 492 Query: 47 -RHGLPNLVVEPETSYTIDIMPP---NAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWT 102 N ++ I ++ P + + F + + VK + Sbjct: 493 WNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNEN 552 Query: 103 PEG-----RRLVVATYSGEFSLWNASSFTFET----LMQAHDSAVTTMKYSHDSDWMISG 153 +G + + WN S + + V + + D+ ++ Sbjct: 553 GDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTV 612 Query: 154 ---DADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGK 210 + + I Q + + + I D F + CS ++I++ S Sbjct: 613 QPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQI 671 Query: 211 QERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW-DPR-SGNCISSILKFKHTVLKTR 268 + L + D HP + ++S D V LW D + ++ + V Sbjct: 672 LVKKLLPGARWLSKIDIHPRGDNLIASSFDKRV-LWHDLDLASTPYKTLRYHEKAVRSVN 730 Query: 269 FQPTKGNLLMAISKDKSCRVFDI--------RYSMKELMCVRDETDYMTL-----EWHPI 315 F L + + D + VF + L + +L WHP Sbjct: 731 FHKKLP-LFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPR 789 Query: 316 NESMFTLACYDGSLKHF 332 +F A D + + + Sbjct: 790 EAWLF-SAGADNTARLW 805 >6CB1-s nrPDB Length = 569 Score = 93.7 bits (231), Expect = 2e-19, Method: Composition-based stats. Identities = 57/378 (15%), Positives = 127/378 (33%), Gaps = 57/378 (15%) Query: 39 YINLYYNRRHGLPNLVVEPETSYTIDIMP-PNAYRGRDRVINLPSKFTHLSSNKVKHVIP 97 ++LY R L ++P + I +P P R P + + + K + Sbjct: 153 SLDLYLAPRVRKNKLNIDPNS--LIPELPSPKDLR------PFPIRCSTI-YAGHKGKVR 203 Query: 98 AIQWTPEGRRLVVATYSGEFSLWNASSF------TFETLMQAHDSAVTTMKYSHDSD--W 149 + P G L + G +W + T + D + ++++ D++ Sbjct: 204 TLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGI 263 Query: 150 MISGDADGMIKI------WQPNFSMVKEIDAA----HTESI--RDMAFSSNDSKFVTCSD 197 + + + I + + +I+ ++ ++ + N + Sbjct: 264 LAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGD----GDE 319 Query: 198 D-----------NILKIWNFSNGKQER----VLSGHHWDVKSCDWHPEMGLIASASKDN- 241 D + WN + KQ + VK WH + + D+ Sbjct: 320 DGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQPDSG 379 Query: 242 --LVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELM 299 V + S K K ++ +F P K L + + R++D+ + Sbjct: 380 NTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFV--CSQRYVRIYDLSQQILVKK 437 Query: 300 CVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYN 359 + ++ HP +++ +D + DL +L H+K + S++++ Sbjct: 438 LLPGARWLSKIDIHPRGDNLIAS-SFDKRVLWHDL--DLASTPYKTLRYHEKAVRSVNFH 494 Query: 360 PVGHIFATAAKDRTIRFW 377 +F++AA D TI + Sbjct: 495 KKLPLFSSAADDGTIHVF 512 Score = 92.1 bits (227), Expect = 5e-19, Method: Composition-based stats. Identities = 62/364 (17%), Positives = 120/364 (32%), Gaps = 58/364 (15%) Query: 66 MPPNAYRGRDRVINLPSKFTH------LSSNKVKHVIPAIQWTPEGRRLVVATYSGE-FS 118 + + G RV + + + I I+W P+ ++A GE Sbjct: 214 LATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIH 273 Query: 119 L-------WNASSFTFETLMQA------HDSAVTTMKYSHDSDWMISGDADG-------- 157 L ++ + + + ++ + + D GD DG Sbjct: 274 LIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGD----GDEDGENESAKNA 329 Query: 158 ---MIKIWQPNFSMVKE----IDAAHTESIRDMAFSSNDSKFVTC---SDDNILKIWNFS 207 + W E I + ++++ +++ FVT S + + I S Sbjct: 330 VKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVS 389 Query: 208 NGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKT 267 + + +HP + S+ V+++D + +L + K Sbjct: 390 KHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKI 448 Query: 268 RFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVR-DETDYMTLEWHPINESMFTLACYD 326 P NL+ + S DK D+ + +R E ++ +H +F+ A D Sbjct: 449 DIHPRGDNLIAS-SFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFH-KKLPLFSSAADD 506 Query: 327 GSLKHF------DLLQNLNEPILTIPYAHDKCITSLS-----YNPVGHIFATAAKDRTIR 375 G++ F D+++N L H K I SL ++P +A D T R Sbjct: 507 GTIHVFHATVYDDMMKNPMIVPLKKLTGH-KVINSLGVLDAIWHPREAWLFSAGADNTAR 565 Query: 376 FWTR 379 WT Sbjct: 566 LWTT 569 Score = 91.0 bits (224), Expect = 1e-18, Method: Composition-based stats. Identities = 50/377 (13%), Positives = 103/377 (27%), Gaps = 49/377 (12%) Query: 1 MDGHNQNQY------QNQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNR-------- 46 GH S ++ + + I+ N Sbjct: 195 YAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIE 254 Query: 47 -RHGLPNLVVEPETSYTIDIMPP---NAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWT 102 N ++ I ++ P + + F + + VK + Sbjct: 255 WNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNEN 314 Query: 103 PEG-----RRLVVATYSGEFSLWNASSFTFET----LMQAHDSAVTTMKYSHDSDWMISG 153 +G + + WN S + + V + + D+ ++ Sbjct: 315 GDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTV 374 Query: 154 ---DADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGK 210 + + I Q + + + I D F + CS ++I++ S Sbjct: 375 QPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQI 433 Query: 211 QERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW-DPR-SGNCISSILKFKHTVLKTR 268 + L + D HP + ++S D V LW D + ++ + V Sbjct: 434 LVKKLLPGARWLSKIDIHPRGDNLIASSFDKRV-LWHDLDLASTPYKTLRYHEKAVRSVN 492 Query: 269 FQPTKGNLLMAISKDKSCRVFDI--------RYSMKELMCVRDETDYMTL-----EWHPI 315 F L + + D + VF + L + +L WHP Sbjct: 493 FHKKLP-LFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPR 551 Query: 316 NESMFTLACYDGSLKHF 332 +F A D + + + Sbjct: 552 EAWLF-SAGADNTARLW 567 >6EM1-m nrPDB Length = 807 Score = 93.3 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 57/378 (15%), Positives = 127/378 (33%), Gaps = 57/378 (15%) Query: 39 YINLYYNRRHGLPNLVVEPETSYTIDIMP-PNAYRGRDRVINLPSKFTHLSSNKVKHVIP 97 ++LY R L ++P + I +P P R P + + + K + Sbjct: 391 SLDLYLAPRVRKNKLNIDPNS--LIPELPSPKDLR------PFPIRCSTI-YAGHKGKVR 441 Query: 98 AIQWTPEGRRLVVATYSGEFSLWNASSF------TFETLMQAHDSAVTTMKYSHDSD--W 149 + P G L + G +W + T + D + ++++ D++ Sbjct: 442 TLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGI 501 Query: 150 MISGDADGMIKI------WQPNFSMVKEIDAA----HTESI--RDMAFSSNDSKFVTCSD 197 + + + I + + +I+ ++ ++ + N + Sbjct: 502 LAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGD----GDE 557 Query: 198 D-----------NILKIWNFSNGKQER----VLSGHHWDVKSCDWHPEMGLIASASKDN- 241 D + WN + KQ + VK WH + + D+ Sbjct: 558 DGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQPDSG 617 Query: 242 --LVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELM 299 V + S K K ++ +F P K L + + R++D+ + Sbjct: 618 NTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFV--CSQRYVRIYDLSQQILVKK 675 Query: 300 CVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYN 359 + ++ HP +++ +D + DL +L H+K + S++++ Sbjct: 676 LLPGARWLSKIDIHPRGDNLIAS-SFDKRVLWHDL--DLASTPYKTLRYHEKAVRSVNFH 732 Query: 360 PVGHIFATAAKDRTIRFW 377 +F++AA D TI + Sbjct: 733 KKLPLFSSAADDGTIHVF 750 Score = 91.7 bits (226), Expect = 6e-19, Method: Composition-based stats. Identities = 62/364 (17%), Positives = 120/364 (32%), Gaps = 58/364 (15%) Query: 66 MPPNAYRGRDRVINLPSKFTH------LSSNKVKHVIPAIQWTPEGRRLVVATYSGE-FS 118 + + G RV + + + I I+W P+ ++A GE Sbjct: 452 LATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIH 511 Query: 119 L-------WNASSFTFETLMQA------HDSAVTTMKYSHDSDWMISGDADG-------- 157 L ++ + + + ++ + + D GD DG Sbjct: 512 LIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGD----GDEDGENESAKNA 567 Query: 158 ---MIKIWQPNFSMVKE----IDAAHTESIRDMAFSSNDSKFVTC---SDDNILKIWNFS 207 + W E I + ++++ +++ FVT S + + I S Sbjct: 568 VKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVS 627 Query: 208 NGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKT 267 + + +HP + S+ V+++D + +L + K Sbjct: 628 KHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKI 686 Query: 268 RFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVR-DETDYMTLEWHPINESMFTLACYD 326 P NL+ + S DK D+ + +R E ++ +H +F+ A D Sbjct: 687 DIHPRGDNLIAS-SFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFH-KKLPLFSSAADD 744 Query: 327 GSLKHF------DLLQNLNEPILTIPYAHDKCITSLS-----YNPVGHIFATAAKDRTIR 375 G++ F D+++N L H K I SL ++P +A D T R Sbjct: 745 GTIHVFHATVYDDMMKNPMIVPLKKLTGH-KVINSLGVLDAIWHPREAWLFSAGADNTAR 803 Query: 376 FWTR 379 WT Sbjct: 804 LWTT 807 >3I2N-A nrPDB Length = 357 Score = 92.9 bits (229), Expect = 3e-19, Method: Composition-based stats. Identities = 50/335 (14%), Positives = 108/335 (32%), Gaps = 59/335 (17%) Query: 72 RGRDRVINLPS-KFTHLSSNKVKHVIPAIQW---TPEGRRLVVATYSGEFSLWNASSFTF 127 G ++ + L + I + + + R L + G +WN + Sbjct: 43 TGVIQLYEIQHGDLKLLREIEKAKPIKCGTFGATSLQQRYLATGDFGGNLHIWNLEAPEM 102 Query: 128 -ETLMQAHDSAVTTMKYSHDSDW------MISGDADGMIKIWQPNFSM-----VKEIDAA 175 ++ H + + +++G DG +K+W P ++ + Sbjct: 103 PVYSVKGHKEIINAIDGIGGLGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGE 162 Query: 176 HTESIRDMAF----SSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPE- 230 + +AF + + D+ +K+++ N R + V S ++ + Sbjct: 163 NKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRNMA-LRWETNIKNGVCSLEFDRKD 221 Query: 231 ---MGLIASASKDNLVKLWDPRS-----GNCISSILKFKHTVLKTRFQPTKGNLLMAISK 282 L+A+ S + ++D R+ G S K TV + R P L + Sbjct: 222 ISMNKLVAT-SLEGKFHVFDMRTQHPTKGFASVSEKAHKSTVWQVRHLPQNRELFLTAGG 280 Query: 283 DKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPI 342 ++ Y ++ E M + LLQN+ Sbjct: 281 AGGLHLWKYEYPIQR-SKKDSEGIEMGVAGS------------------VSLLQNVTLS- 320 Query: 343 LTIPYAHDKCITSLSYNPVGH-IFATAAKDRTIRF 376 + I+SL ++P + ++ D+T+R Sbjct: 321 -------TQPISSLDWSPDKRGLCVCSSFDQTVRV 348 Score = 75.9 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 47/288 (16%), Positives = 95/288 (32%), Gaps = 29/288 (10%) Query: 125 FTFETLMQAHDSAVTTMKYSHDSDWMIS----GDADGMIKIWQPNFSMVKEIDAAHT-ES 179 + + + V K+ S ++ G+I++++ +K + + Sbjct: 8 QIIAHIQKGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKP 67 Query: 180 IRDMAFSSND---SKFVTCSDDNILKIWNFSNGK-QERVLSGHHWDVKSCDWHPEMGL-- 233 I+ F + T L IWN + + GH + + D +G+ Sbjct: 68 IKCGTFGATSLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGE 127 Query: 234 ----IASASKDNLVKLWDPRSG-NCISSILKFKHT----VLKTRFQPTKGN---LLMAIS 281 I + S+D VK+WDPR + ++++ + F ++ A Sbjct: 128 GAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGY 187 Query: 282 KDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESM--FTLACYDGSLKHFDLLQNLN 339 + ++FD+R + +LE+ + SM +G FD+ Sbjct: 188 DNGDIKLFDLRNMALRWET-NIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHP 246 Query: 340 EP--ILTIPYAHDKCITSLSYNPVGH-IFATAAKDRTIRFWTRARPID 384 AH + + + P +F TA + W PI Sbjct: 247 TKGFASVSEKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQ 294 Score = 63.6 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 27/220 (12%), Positives = 68/220 (30%), Gaps = 39/220 (17%) Query: 64 DIMPPNAYRGRDRVINLPSKFTHLS---------SNKVKHVIPAIQWTPEGRRLVVATYS 114 + + G +V + K ++ V + E R + + Sbjct: 130 PEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDN 189 Query: 115 GEFSLWNASSFTFETLMQAHDSAVTTMKYSH---DSDWMISGDADGMIKIWQ-----PNF 166 G+ L++ + + V ++++ + +++ +G ++ P Sbjct: 190 GDIKLFDLRNMALRWETNI-KNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTK 248 Query: 167 SMVKEIDAAHTESIRDMAFSS-NDSKFVTCSDDNILKIWNFS------------------ 207 + AH ++ + N F+T L +W + Sbjct: 249 GFASVSEKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRSKKDSEGIEMGVA 308 Query: 208 -NGKQERVLSGHHWDVKSCDWHPEM-GLIASASKDNLVKL 245 + + ++ + S DW P+ GL +S D V++ Sbjct: 309 GSVSLLQNVTLSTQPISSLDWSPDKRGLCVCSSFDQTVRV 348 Score = 58.2 bits (139), Expect = 6e-09, Method: Composition-based stats. Identities = 26/168 (15%), Positives = 59/168 (35%), Gaps = 14/168 (8%) Query: 255 SSILKFKHTVLKTRFQPTKGNLLMAIS---KDKSCRVFDIRY-SMKELMCVRDETDYMTL 310 F +TV ++ P + + ++++I++ +K L + Sbjct: 12 HIQKGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKCG 71 Query: 311 EW--HPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHI---- 364 + + + + G+L ++L P+ ++ H + I ++ I Sbjct: 72 TFGATSLQQRYLATGDFGGNLHIWNLEA-PEMPVYSV-KGHKEIINAIDGIGGLGIGEGA 129 Query: 365 --FATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFFGINNDIN 410 T ++D T++ W + DP A +P K + W N N Sbjct: 130 PEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYN 177 Score = 57.4 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 24/220 (10%), Positives = 76/220 (34%), Gaps = 33/220 (15%) Query: 14 QIQQSQQPPLKKYVTQRRSVDVSS-PYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYR 72 + S+ +K + +++ V++ + R + Sbjct: 132 IVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCA--GYDN 189 Query: 73 GRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEG---RRLVVATYSGEFSLWNASSFTFET 129 G ++ +L + +N +K+ + ++++ + +LV + G+F +++ + Sbjct: 190 GDIKLFDLRNMALRWETN-IKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTK 248 Query: 130 -----LMQAHDSAVTTMKYSHDSDWM-ISGDADGMIKIWQPNFSMVKEID---------- 173 +AH S V +++ + + ++ G + +W+ + + + Sbjct: 249 GFASVSEKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRSKKDSEGIEMGVA 308 Query: 174 ---------AAHTESIRDMAFSSNDSKFVTCSD-DNILKI 203 T+ I + +S + CS D +++ Sbjct: 309 GSVSLLQNVTLSTQPISSLDWSPDKRGLCVCSSFDQTVRV 348 >3JZG-A nrPDB Length = 402 Score = 91.7 bits (226), Expect = 6e-19, Method: Composition-based stats. Identities = 60/326 (18%), Positives = 110/326 (33%), Gaps = 53/326 (16%) Query: 64 DIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTP-EGRRLVVATYSGEFSLWNA 122 ++ RG R+IN + + I +++ P + L+ + LWN Sbjct: 122 PLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNI 181 Query: 123 SSFTFETLM---QAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTES 179 + T + + H V + Y + ++S D +K+W+ N + Sbjct: 182 QTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKE---- 237 Query: 180 IRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASK 239 ++ N +K + +FS H V W LI S S Sbjct: 238 ----SYDYNPNKTNRPFISQKIHFPDFSTRDI------HRNYVDCVRWL--GDLILSKSC 285 Query: 240 DNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKS-CRVFDIRYSMKEL 298 +N + W P K + + K + P++ N+ + D S C ++ +R+SM Sbjct: 286 ENAIVCWKPG---------KMEDDIDKIK--PSESNVTILGRFDYSQCDIWYMRFSMDFW 334 Query: 299 MCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDL-LQNLNEPILTIPYAHD--KCITS 355 + M L G L +DL +++ ++ T H I Sbjct: 335 ------------------QKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQ 376 Query: 356 LSYNPVGHIFATAAKDRTIRFWTRAR 381 S++ I D +I W R R Sbjct: 377 TSFSRDSSILIAVCDDASIWRWDRLR 402 Score = 77.1 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 50/313 (15%), Positives = 120/313 (38%), Gaps = 39/313 (12%) Query: 124 SFTFETLMQA-HDSAVTTMKY---SHDSDWMISGD-ADGMIKIWQPNFS-----MVKEID 173 SF ++ H+ + +++ S + D ++ + +++ + + +D Sbjct: 42 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVD 101 Query: 174 AAHTESIRDMAFSSNDS----KFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHP 229 A E+ A++ + + I++I N + + GH + +HP Sbjct: 102 ADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHP 161 Query: 230 -EMGLIASASKDNLVKLWDPRSGNCISSI---LKFKHTVLKTRFQPTKGNLLMAISKDKS 285 + L+ S SKD+ ++LW+ ++ ++ + VL + G +M+ D S Sbjct: 162 RDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYD-LLGEKIMSCGMDHS 220 Query: 286 CRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTI 345 +++ I S + + +++ DY + + + F + Q ++ P + Sbjct: 221 LKLWRIN-SKRMMNAIKESYDYN----------------PNKTNRPF-ISQKIHFPDFST 262 Query: 346 PYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFFGI 405 H + + + +G + + + + I W + D P+ +N I G F Sbjct: 263 RDIHRNYVDCVRW--LGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYS 320 Query: 406 NNDINAVREKSEF 418 DI +R +F Sbjct: 321 QCDIWYMRFSMDF 333 >6CHG-D nrPDB Length = 439 Score = 91.7 bits (226), Expect = 6e-19, Method: Composition-based stats. Identities = 48/341 (14%), Positives = 112/341 (32%), Gaps = 43/341 (12%) Query: 81 PSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSA--- 137 P K TH V V ++++P G L V +G +++ S ++ H A Sbjct: 17 PEKLTHTLEVPVAAV--CVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTR 74 Query: 138 -VTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCS 196 V ++ +S+D ++ S D K+W + + VT Sbjct: 75 SVQSVCWSNDGRYLWSSGRDWYAKLWDMTQPTKCFQQYKFDGPLWSCHVVRWNVCIVTVV 134 Query: 197 DDNILKIWNFSNG----------KQERVLSGHHWDVKSCDWHPE-MGLIASASKDNLVK- 244 ++ + ++ +Q++ +SGH + + +C HP +I + + + Sbjct: 135 EEPTAYVLTLTDRQNAFHCFPLLEQDQDISGHGYTLVACP-HPTIESIIITGTSKGWINA 193 Query: 245 -LWDPRSG-----NCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDI------- 291 D SG C + + P+ G + D++ R + + Sbjct: 194 FQLDLESGFEDKIRCCYEEKIANANIKQIIISPS-GTRIAINGSDRTIRQYQLIVEDNES 252 Query: 292 -RYSMKELMCVRDET--------DYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPI 342 S + + + T+ + + + + S L + + + Sbjct: 253 EGGSSHSVSIELEHKYQDIINRLQWNTIFFSNHSGEYLVASAHGSSAHDLYLWETSSGSL 312 Query: 343 LTIPYAHDKCITSLSYNPVGHIFATAA-KDRTIRFWTRARP 382 + + D+ + + +N A+ + + W+ P Sbjct: 313 VRVLEGADEELLDIDWNFYSMRIASNGFESGWVYMWSIVIP 353 Score = 56.7 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 11/86 (12%), Positives = 33/86 (38%), Gaps = 2/86 (2%) Query: 308 MTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYA-HDKCITSLSYNPVGHIFA 366 + +++ P + + C +G++ +D+ +L H + + S+ ++ G Sbjct: 31 VCVKFSPRGDY-LAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSVQSVCWSNDGRYLW 89 Query: 367 TAAKDRTIRFWTRARPIDPNAYDDPT 392 ++ +D + W +P Sbjct: 90 SSGRDWYAKLWDMTQPTKCFQQYKFD 115 >2P9P-C nrPDB Length = 372 Score = 90.2 bits (222), Expect = 2e-18, Method: Composition-based stats. Identities = 43/258 (16%), Positives = 86/258 (33%), Gaps = 29/258 (11%) Query: 95 VIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFE--TLMQAHDSAVTTMKYSHDSDWMIS 152 I W + ++ + + E ++ S + ++ H+ VT + ++ DS+ +++ Sbjct: 10 PISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIVT 69 Query: 153 GDADGMIKIWQPNFSMVKEIDAAH--TESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGK 210 D +W K + R + ++ N+ KF S ++ I F Sbjct: 70 CGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQEN 129 Query: 211 ----QERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKL----------------W--DP 248 + + V S DWHP L+A+ S D ++ W Sbjct: 130 DWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKM 189 Query: 249 RSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYM 308 G + V F G+ + +S D + + D M + + Sbjct: 190 PFGELMFESSSSCGWVHGVCFSA-NGSRVAWVSHDSTVCLADADKKMAVATLASETLPLL 248 Query: 309 TLEWHPINESMFTLACYD 326 + + I ES A +D Sbjct: 249 AVTF--ITESSLVAAGHD 264 Score = 87.1 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 41/318 (12%), Positives = 87/318 (27%), Gaps = 35/318 (11%) Query: 90 NKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAH--DSAVTTMKYSHDS 147 + + + W P+ R+V +W T++ + + A ++++ + Sbjct: 49 KEHNGQVTGVDWAPDSNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNE 108 Query: 148 DWMISGDADGMIKI--WQPNFS--MVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKI 203 G +I I ++ + K I ++ + + N S D +I Sbjct: 109 KKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRI 168 Query: 204 WNFSNGKQERV------------------LSGHHWDVKSCDWHPEMGLIASASKDNLVKL 245 ++ + E S V + +A S D+ V L Sbjct: 169 FSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTVCL 228 Query: 246 WDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDET 305 D ++++ +L F L+A D +F + +L Sbjct: 229 ADADKKMAVATLASETLPLLAVTFITESS--LVAAGHDCFPVLFTYDSAAGKLS-FGGRL 285 Query: 306 DYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHI- 364 D + D + + H ++ +S G Sbjct: 286 DVPKQSSQRGLTARERFQNLDKKAS----SEGSAAAGAGLDSLHKNSVSQISVLSGGKAK 341 Query: 365 ---FATAAKDRTIRFWTR 379 F T D + W Sbjct: 342 CSQFCTTGMDGGMSIWDV 359 Score = 44.7 bits (104), Expect = 8e-05, Method: Composition-based stats. Identities = 10/74 (13%), Positives = 24/74 (32%), Gaps = 2/74 (2%) Query: 306 DYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIF 365 W+ + + + + + ++ N + H+ +T + + P + Sbjct: 10 PISCHAWN-KDRTQIAICPNNHEVHIYEKSGNKWVQV-HELKEHNGQVTGVDWAPDSNRI 67 Query: 366 ATAAKDRTIRFWTR 379 T DR WT Sbjct: 68 VTCGTDRNAYVWTL 81 Score = 39.0 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 21/184 (11%), Positives = 47/184 (25%), Gaps = 19/184 (10%) Query: 263 TVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSM--KELMCVRDETDYMTLEWHPINESMF 320 + + + + +++ + + ++W P + Sbjct: 10 PISCHAWN-KDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNR-I 67 Query: 321 TLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRF---- 376 D + + L +P L I ++ + + P FA + R I Sbjct: 68 VTCGTDRNAYVWTLKGRTWKPTLVILRI-NRAARCVRWAPNEKKFAVGSGSRVISICYFE 126 Query: 377 ----WTRARPIDPNAYDDPTYNNKKINGWFFGINNDINAVR------EKSEFGAAPPPPA 426 W + I + N + R ++ E AP P Sbjct: 127 QENDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWG 186 Query: 427 TLEP 430 + P Sbjct: 187 SKMP 190 >5A9Q-2 nrPDB Length = 326 Score = 87.5 bits (215), Expect = 1e-17, Method: Composition-based stats. Identities = 35/233 (15%), Positives = 81/233 (34%), Gaps = 29/233 (12%) Query: 177 TESIRDMAFSS----NDSKFVTCSDDNILKI---------WNFSNGKQERVLSGHHW-DV 222 + + + F+ + + +N + I + + + + + HH V Sbjct: 16 EDYVHVVEFNPFENGDSGNLIAYGGNNYVVIGTCTFQEEEADVEGIQYKTLRTFHHGVRV 75 Query: 223 KSCDWHPEMGL--------IASASKDNLVKLW--DPRSGNCISSILKFKHTVLKTRFQPT 272 W PE L +++ D ++L+ D + N + + F P Sbjct: 76 DGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLEGHTDFINGLVFDPK 135 Query: 273 KGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHF 332 +G + ++S D +CR++++ + + M++ WHP +A +G+++ + Sbjct: 136 EGQEIASVSDDHTCRIWNLEGVQTAHFVL--HSPGMSVCWHPEETFKLMVAEKNGTIRFY 193 Query: 333 DLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDP 385 DLL + + + + S + A W R P Sbjct: 194 DLL---AQQAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWLIWDITRSSYP 243 Score = 68.6 bits (166), Expect = 5e-12, Method: Composition-based stats. Identities = 32/266 (12%), Positives = 73/266 (27%), Gaps = 28/266 (10%) Query: 42 LYYNRRHGLPNLVVEPETSYTIDIMPP------NAYRGRDRVI--NLPSKFTHLSSNKVK 93 ++ + + PET +D +PP +A + R+ +L K + Sbjct: 67 RTFHHGVRVDGIAWSPETR--LDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLEGHT 124 Query: 94 HVIPAIQWTP-EGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDW-MI 151 I + + P EG+ + + +WN H ++ + + + ++ Sbjct: 125 DFINGLVFDPKEGQEIASVSDDHTCRIWNLE-GVQTAHFVLHSPG-MSVCWHPEETFKLM 182 Query: 152 SGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQ 211 + +G I+ + + + + ++ V N IW+ + Sbjct: 183 VAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWLIWDITRSSY 242 Query: 212 ERVLSG-HHWDVKSCDWHP-EMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVL--KT 267 + H W L A+ + + L +L Sbjct: 243 PQNKRPVHMDRACLFRWSTISENLFATTGYPGKM------ASQFQIHHLGHPQPILMGSV 296 Query: 268 RFQPTKGNL----LMAISKDKSCRVF 289 L I D + Sbjct: 297 AVGSGLSWHRTLPLCVIGGDHKLLFW 322 >5BJS-A nrPDB Length = 605 Score = 87.5 bits (215), Expect = 1e-17, Method: Composition-based stats. Identities = 33/226 (14%), Positives = 69/226 (30%), Gaps = 31/226 (13%) Query: 49 GLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWT----PE 104 G P + + + P + L + A W+ + Sbjct: 92 GAPPVFAATSKKHAVICRLTQTTDKDAN----PCEIIQLIRDDGNEANCASCWSKDPITD 147 Query: 105 GRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDW-MISGDADGMIKIWQ 163 L +A G ++N + + H + + S + + + S D I+IW Sbjct: 148 QPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIWS 207 Query: 164 PNFSMVKE------IDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNF-----SNGKQE 212 K+ H+ + +AF N ++ D ++ +W + + Sbjct: 208 LAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPEFPNEHMEIP 267 Query: 213 RVLSG--------HHWDVKSCDWHPEMGLIAS-ASKDNLVKLWDPR 249 V+ H+ V ++ LI S A ++ + LW Sbjct: 268 IVIYYPHFSSSEIHNNLVDCVAFY--GDLILSRACHEDTIVLWRIE 311 Score = 81.3 bits (199), Expect = 8e-16, Method: Composition-based stats. Identities = 30/179 (16%), Positives = 68/179 (37%), Gaps = 24/179 (13%) Query: 230 EMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVF 289 + L+ A + VK+++ G +++ + P ++ + S D + R++ Sbjct: 147 DQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIW 206 Query: 290 DIRYSMKELMCV------RDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNE--- 340 + ++ CV D +++ +H N A +D + + L + NE Sbjct: 207 SLAPEHEKQPCVCILGGEGHSYDLLSVAFH-DNGRYVLSAGHDQVINLWALPEFPNEHME 265 Query: 341 -------PILTIPYAHDKCITSLSYNPVGHIFAT-AAKDRTIRFWTRARPIDPNAYDDP 391 P + H+ + +++ G + + A + TI W I+ + DDP Sbjct: 266 IPIVIYYPHFSSSEIHNNLVDCVAF--YGDLILSRACHEDTIVLW----RIEGFSSDDP 318 Score = 72.5 bits (176), Expect = 4e-13, Method: Composition-based stats. Identities = 18/113 (15%), Positives = 38/113 (33%), Gaps = 3/113 (2%) Query: 272 TKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKH 331 T LL + + +V+++ V L P N + A D +++ Sbjct: 146 TDQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRI 205 Query: 332 FDLLQNLNEP---ILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRAR 381 + L + + H + S++++ G +A D+ I W Sbjct: 206 WSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPE 258 >3JB9-S nrPDB Length = 488 Score = 87.1 bits (214), Expect = 2e-17, Method: Composition-based stats. Identities = 37/283 (13%), Positives = 103/283 (36%), Gaps = 21/283 (7%) Query: 102 TPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKI 161 +PE V+ + E + S + + + + + S + AD I I Sbjct: 218 SPENSSFVLCLHKDELLCLDIQSNSTLKIFEG---SALACCW-LTSSKIAVATADA-ISI 272 Query: 162 WQ--PNFSMVKEIDAAHTE-----SIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERV 214 ++ + S ++ + + + + + + S++ I++ + Sbjct: 273 FEFPVSSSGLQSVGEPTSSIPIDEKVNFLQAHPSGEYLLAASNEK-CYIFSLKSQVYNIT 331 Query: 215 LSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKG 274 ++ H + S HP+ L + ++ ++ ++ SGN ++ V +F Sbjct: 332 VAQH---ITSLAVHPDGNLFVAGLENGELRFFETSSGNELTKFGPHSSPVKTLQFGENGY 388 Query: 275 NLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDL 334 L++ + D ++D+R S + + + +T + ++ L DG + + Sbjct: 389 WLVVTTNDDSDIFIWDLRKS-ELVQKIPLQTKVAAVSLDITSQ---LLVSSDGETLYVHI 444 Query: 335 LQNLNEPILTIPYAHDKCITSLSY-NPVGHIFATAAKDRTIRF 376 ++ + H I++L + N + + + + +R Sbjct: 445 YVKSSKSWRCMSQTHVSSISNLVWLNELHQLLFSTSNGAILRL 487 Score = 70.5 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 36/197 (18%), Positives = 77/197 (39%), Gaps = 13/197 (6%) Query: 50 LPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLV 109 + L P Y + A + + +L S+ +++ + I ++ P+G V Sbjct: 298 VNFLQAHPSGEYLLA-----ASNEKCYIFSLKSQVYNITVAQH---ITSLAVHPDGNLFV 349 Query: 110 VATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWM-ISGDADGMIKIWQPNFSM 168 +GE + SS T H S V T+++ + W+ ++ + D I IW S Sbjct: 350 AGLENGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKSE 409 Query: 169 VKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIW-NFSNGKQERVLSG-HHWDVKSCD 226 + + T+ + ++ V+ SD L + + K R +S H + + Sbjct: 410 LVQKIPLQTK-VAAVSLDITSQLLVS-SDGETLYVHIYVKSSKSWRCMSQTHVSSISNLV 467 Query: 227 WHPEMGLIASASKDNLV 243 W E+ + ++ + + Sbjct: 468 WLNELHQLLFSTSNGAI 484 Score = 47.8 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 36/196 (18%), Positives = 65/196 (33%), Gaps = 28/196 (14%) Query: 228 HPEMGLIASA-SKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSC 286 PE KD L+ L D +S + + + + + D + Sbjct: 218 SPENSSFVLCLHKDELLCL-DIQSNSTLKIFEGS-----ALACCWLTSSKIAVATAD-AI 270 Query: 287 RVFDIRYSMKELMCVRD-------ETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLN 339 +F+ S L V + + L+ HP E + A + F L Sbjct: 271 SIFEFPVSSSGLQSVGEPTSSIPIDEKVNFLQAHPSGEYLL--AASNEKCYIFSL----K 324 Query: 340 EPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRA--RPIDPNAYDDPTYNNKK 397 + I A + ITSL+ +P G++F ++ +RF+ + + + Sbjct: 325 SQVYNITVA--QHITSLAVHPDGNLFVAGLENGELRFFETSSGNELTKFGPHSSPVKTLQ 382 Query: 398 I--NG-WFFGINNDIN 410 NG W ND + Sbjct: 383 FGENGYWLVVTTNDDS 398 >5MC6-j nrPDB Length = 397 Score = 81.7 bits (200), Expect = 6e-16, Method: Composition-based stats. Identities = 52/314 (16%), Positives = 105/314 (33%), Gaps = 63/314 (20%) Query: 11 NQNQIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLP-------------NLVVEP 57 N + S LK + + + ++ + GL L + Sbjct: 26 NSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHVDVLQAIERDAFELCLVA 85 Query: 58 ETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVV----ATY 113 TS++ D++ R + + K L S+ KH A++W RL+ AT Sbjct: 86 TTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFWALKWGASNDRLLSHRLVATD 145 Query: 114 -SGEFSLW---------NASSFTFETLMQAH---------DSAVTTMKYSHDSDWMISGD 154 G +W N+ + + ++ T++ S + +G Sbjct: 146 VKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPSQFATSVDISERG-LIATGF 204 Query: 155 ADGMIKIWQPNFSMVKE---IDAAHT-----ESIRDMAFSSNDSKFVTCSDDNI---LKI 203 +G ++I S ++ ++ H+ SIR + FS S D N + + Sbjct: 205 NNGTVQI--SELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSLLAIAHDSNSFGCITL 262 Query: 204 WNFSNGKQERVLS-------------GHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRS 250 + G++ LS H V S ++ + SA D ++ WD ++ Sbjct: 263 YETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKT 322 Query: 251 GNCISSILKFKHTV 264 I+++ + Sbjct: 323 KERITTLNMHCDDI 336 Score = 61.7 bits (148), Expect = 7e-10, Method: Composition-based stats. Identities = 52/369 (14%), Positives = 113/369 (30%), Gaps = 95/369 (25%) Query: 132 QAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ------------PNFSMVKEIDAAHTES 179 +AHD+ + ++ S + + +S DG +K+W V + H + Sbjct: 13 KAHDADIFSV--SACNSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHVDV 70 Query: 180 IRDM-------------AFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCD 226 ++ + +FS + + +D K+ + + H + Sbjct: 71 LQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHS--FWALK 128 Query: 227 WHPEMGLIAS---ASKD--NLVKLW------DPRSGNCI--SSILKFKHTV--------L 265 W + S + D +W D + + S L+ + TV Sbjct: 129 WGASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPSQF 188 Query: 266 KTRFQPTKGNLLMAISKDKSCRVFDIRYSMK------ELMCVRDETDYMTLEWHPINESM 319 T ++ L+ + + ++ ++ + + + ++++ P S+ Sbjct: 189 ATSVDISERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQG-SL 247 Query: 320 FTLACYDGS---LKHFDLLQNLNEPILTIP----------YAHDKCITSLSYNPVGHIFA 366 +A S + ++ L++P +AH + SLS+N G Sbjct: 248 LAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGETLC 307 Query: 367 TAAKDRTIRFWT--RARPIDPNAYD-----------------DPTYNNKKIN------GW 401 +A D +RFW I D + GW Sbjct: 308 SAGWDGKLRFWDVKTKERITTLNMHCDDIEIEEDILAVDEHGDSLAEPGVFDVKFLKKGW 367 Query: 402 FFGINNDIN 410 G+ D+N Sbjct: 368 RSGMGADLN 376 >5YZG-2 nrPDB Length = 646 Score = 77.1 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 34/227 (14%), Positives = 78/227 (34%), Gaps = 29/227 (12%) Query: 175 AHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNG--KQERVLSGHHWDVKSCDWHPEMG 232 H + I + + +T S D +K W + + H ++S E Sbjct: 88 MHRDVITHV-VCTKTDFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSSEGA 146 Query: 233 LIASASKDNLVKLWDPRSGNCISSIL-----KFKHTVLKTRFQPTKGNLLMAISKDKSCR 287 L S D +K++D + + I+ + + + P +A S+ + + Sbjct: 147 LFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWI----YCPGDAISSVAASEKSTGK 202 Query: 288 V--FDIRYSMKELMCVR--DETDYMTLEWHPINESMFTLACYDGSLKHFD---------- 333 + +D R + L + + +P+ +++ + G ++++ Sbjct: 203 IFIYDGRGDNQPLHIFDKLHTSPLTQIRLNPVYKAVVSSDKS-GMIEYWTGPPHEYKFPK 261 Query: 334 --LLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWT 378 + + L TS+ ++P G AT DR +R + Sbjct: 262 NVNWEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIATIGSDRKVRIFR 308 Score = 70.5 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 34/283 (12%), Positives = 81/283 (28%), Gaps = 36/283 (12%) Query: 5 NQNQYQNQNQIQQSQQPPL----KKYVTQRRSVD--VSSPYINLYYNRRHGLPNLVVEPE 58 N + + + + L K +R +D S+ Y R +++ Sbjct: 42 NDEENEERWVGPLPVEATLAKKRKVLEFERVYLDNLPSASMYERSYMHR----DVITHVV 97 Query: 59 TSYTIDIMPPNAYRGRDRVINLPSKFTHLS--SNKVKHVIPAIQWTPEGRRLVVATYSGE 116 + T D + ++ G + + VI +I + EG Sbjct: 98 CTKT-DFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSSEGALFCSVGDDKA 156 Query: 117 FSLWNASSFTFETLMQ-----AHDSAVTTMKYSHDSDWMISGDADGMIKIWQP--NFSMV 169 +++ +F +++ + S S + G I I+ + + Sbjct: 157 MKVFDVVNFDMINMLKLGYFPGQCEWIYCPG-DAISSVAASEKSTGKIFIYDGRGDNQPL 215 Query: 170 KEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIW---------------NFSNGKQERV 214 D HT + + + V+ +++ W + Sbjct: 216 HIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFPKNVNWEYKTDTDLYE 275 Query: 215 LSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSI 257 + S + P+ IA+ D V+++ +G + Sbjct: 276 FAKCKAYPTSVCFSPDGKKIATIGSDRKVRIFRFVTGKLMRVF 318 Score = 61.3 bits (147), Expect = 9e-10, Method: Composition-based stats. Identities = 33/182 (18%), Positives = 63/182 (34%), Gaps = 6/182 (3%) Query: 201 LKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWD-PRSG-NCISSIL 258 + + N + H + + I +AS D VK W G + Sbjct: 72 VYLDNLPSASMYERSYMHRDVITHV-VCTKTDFIITASHDGHVKFWKKIEEGIEFVKHFR 130 Query: 259 KFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDI-RYSMKELMCVRDETDYMTLEWHPINE 317 + ++G L ++ DK+ +VFD+ + M ++ + + P + Sbjct: 131 SHLGVIESIAVS-SEGALFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYCPGDA 189 Query: 318 SMFTLACYDGSLKHFDL-LQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRF 376 A + K F + N+P+ H +T + NPV ++ K I + Sbjct: 190 ISSVAASEKSTGKIFIYDGRGDNQPLHIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEY 249 Query: 377 WT 378 WT Sbjct: 250 WT 251 Score = 45.5 bits (106), Expect = 5e-05, Method: Composition-based stats. Identities = 11/60 (18%), Positives = 27/60 (45%), Gaps = 1/60 (1%) Query: 320 FTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTR 379 A +DG +K + ++ E + +H I S++ + G +F + D+ ++ + Sbjct: 104 IITASHDGHVKFWKKIEEGIEFVKH-FRSHLGVIESIAVSSEGALFCSVGDDKAMKVFDV 162 >5AJA-A nrPDB Length = 361 Score = 74.4 bits (181), Expect = 1e-13, Method: Composition-based stats. Identities = 49/260 (18%), Positives = 95/260 (36%), Gaps = 33/260 (12%) Query: 97 PAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMI-SGDA 155 ++ R L++ T +G+ L+N S E H+SA+T ++ S D ++ S Sbjct: 41 TCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSATW 100 Query: 156 DGMIK-IW--QPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQE 212 + +W + F M H + FS + V + +I I++ G + Sbjct: 101 SQPLSALWGMKSVFDMKHSFTEDHY-----VEFSKHSQDRVIGTKGDIAHIYDIQTGNKL 155 Query: 213 RVLSGHH----WDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTR 268 L + ++P L+ D + LWD RS I KF + Sbjct: 156 LTLFNPDLANNYKRNCATFNPTDDLVL---NDGV--LWDVRSAQAIHKFDKFNMNISGV- 209 Query: 269 FQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGS 328 F P +++ + ++D+R L+ D + ++ M+ G+ Sbjct: 210 FHPNGLEVII------NTEIWDLRT--FHLLHTVPALDQCRVVFNHTGTVMY------GA 255 Query: 329 LKHFDLLQNLNEPILTIPYA 348 + D +L E + P+ Sbjct: 256 MLQADDEDDLMEERMKSPFG 275 Score = 34.7 bits (78), Expect = 0.077, Method: Composition-based stats. Identities = 17/96 (17%), Positives = 33/96 (34%), Gaps = 12/96 (12%) Query: 302 RDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPV 361 DE+ + + + C G LK +++ E H+ IT L + Sbjct: 35 EDESGFTCCAFSARERFLMLGTCT-GQLKLYNVFSGQEEASYNC---HNSAITHLEPSRD 90 Query: 362 GHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKK 397 G + T+A W ++P+ ++ K Sbjct: 91 GSLLLTSAT------W--SQPLSALWGMKSVFDMKH 118 >3DWL-C nrPDB Length = 377 Score = 73.2 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 38/218 (17%), Positives = 80/218 (36%), Gaps = 29/218 (13%) Query: 184 AFSSNDSKFVTCSDDNILKIW--NFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDN 241 AF+S ++FVT + N ++++ + + K R S H V DW P+ I + S+D Sbjct: 18 AFNSQRTEFVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSNRIVTCSQDR 77 Query: 242 LVKLWDPR---SGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVF----DIRYS 294 +++ R + +L+ R+ P + + S + V + + Sbjct: 78 NAYVYEKRPDGTWKQTLVLLRLNRAATFVRWSPNE-DKFAVGSGARVISVCYFEQENDWW 136 Query: 295 MKELMCVRDETDYMTLEWHPINESMFTLACYDGSLK----------------HFDLLQNL 338 + + + + ++L+WHP N + C D + Sbjct: 137 VSKHLKRPLRSTILSLDWHP-NNVLLAAGCADRKAYVLSAYVRDVDAKPEASVWGSRLPF 195 Query: 339 NEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRF 376 N P + ++ ++P G+ A A D ++ Sbjct: 196 NTVCAEYPSG--GWVHAVGFSPSGNALAYAGHDSSVTI 231 Score = 72.1 bits (175), Expect = 5e-13, Method: Composition-based stats. Identities = 35/215 (16%), Positives = 72/215 (33%), Gaps = 27/215 (12%) Query: 100 QWTPEGRRLVVATYSGEFSLWNASSFTFET--LMQAHDSAVTTMKYSHDSDWMISGDADG 157 + + V T + + L+ ++ HD VT + ++ S+ +++ D Sbjct: 18 AFNSQRTEFVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSNRIVTCSQDR 77 Query: 158 MIKIWQ--PNFSMVKEI-DAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQE-- 212 +++ P+ + + + + + +S N+ KF S ++ + F Sbjct: 78 NAYVYEKRPDGTWKQTLVLLRLNRAATFVRWSPNEDKFAVGSGARVISVCYFEQENDWWV 137 Query: 213 --RVLSGHHWDVKSCDWHPEMGLIASASKDNL----------------VKLWDPRSG-NC 253 + + S DWHP L+A+ D +W R N Sbjct: 138 SKHLKRPLRSTILSLDWHPNNVLLAAGCADRKAYVLSAYVRDVDAKPEASVWGSRLPFNT 197 Query: 254 ISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRV 288 + + V F P+ GN L D S + Sbjct: 198 VCAEYPSGGWVHAVGFSPS-GNALAYAGHDSSVTI 231 Score = 50.5 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 42/290 (14%), Positives = 97/290 (33%), Gaps = 48/290 (16%) Query: 87 LSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSL--WNASSF--TFETLMQAHDSAVTTMK 142 L ++ ++W+P + V + + S+ + + + L + S + ++ Sbjct: 94 LVLLRLNRAATFVRWSPNEDKFAVGSGARVISVCYFEQENDWWVSKHLKRPLRSTILSLD 153 Query: 143 YSHDSDWMISGDADGM----------------IKIWQ---PNFSMVKEIDAAHTESIRDM 183 + ++ + +G AD +W P ++ E + + + Sbjct: 154 WHPNNVLLAAGCADRKAYVLSAYVRDVDAKPEASVWGSRLPFNTVCAEYPSG--GWVHAV 211 Query: 184 AFSSNDSKFVTCSDDNILKIWNFSNGKQ----ERVLSGHHWDVKSCDWHPEMGLIASASK 239 FS + + D+ + I S +Q + ++S W E ++A+ Sbjct: 212 GFSPSGNALAYAGHDSSVTIAYPSAPEQPPRALITVKLSQLPLRSLLWANESAIVAAGYN 271 Query: 240 DNLVKL------W----DPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVF 289 + + L W D +G S F HT + +G + + + R Sbjct: 272 YSPILLQGNESGWAHTRDLDAGT---SKTSFTHTGNTGEGREEEGPVSFTALR-STFRNM 327 Query: 290 DIRYSMKELMCVRDETDYMTLEWHPINESM-----FTLACYDGSLKHFDL 334 D++ S + + + M P + FT + DG + + L Sbjct: 328 DLKGSSQSISSLPTVHQNMIATLRPYAGTPGNITAFTSSGTDGRVVLWTL 377 Score = 37.8 bits (86), Expect = 0.009, Method: Composition-based stats. Identities = 10/62 (16%), Positives = 24/62 (38%), Gaps = 1/62 (1%) Query: 318 SMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 + F ++ ++ N + HDK +T + + P + T ++DR + Sbjct: 24 TEFVTTTATNQVELYEQDGNGWKH-ARTFSDHDKIVTCVDWAPKSNRIVTCSQDRNAYVY 82 Query: 378 TR 379 + Sbjct: 83 EK 84 >5WLC-LW nrPDB Length = 554 Score = 73.2 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 46/352 (13%), Positives = 118/352 (33%), Gaps = 28/352 (7%) Query: 6 QNQYQNQNQIQQSQQPPLKKYVTQRRSVDVS-SPYINLYYNRRHGLPNLVVEPETSYTID 64 +N+ + ++QQS+ T +++D+S + + +L++ + Sbjct: 77 ENELEKTFKVQQSEIKSSVDVSTANKALDLSLKEFGPYHIKYAKNGTHLLITGRKGHVAS 136 Query: 65 IMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASS 124 + + +G+ R ++ H + + + VA F +++ Sbjct: 137 M---DWRKGQLRAELFLNETCHSA-----------TYLQNEQYFAVAQKKYTF-IYDHE- 180 Query: 125 FTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMA 184 T ++ H + + +++ G +K + + MA Sbjct: 181 GTELHRLKQH-IEARHLDFLPYHYLLVTAGETGWLKYHDVSTGQLVSELRTKAGPTMAMA 239 Query: 185 FSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVK 244 + ++ + + +W+ S + L V S +A+ D +K Sbjct: 240 QNPWNAVMHLGHSNGTVSLWSPSMPEPLVKLLSARGPVNSIAIDRSGYYMATTGADRSMK 299 Query: 245 LWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDE 304 +WD R+ + S+ T L+A+S+ ++ + + Sbjct: 300 IWDIRNFKQLHSVESLPTPGTNVSISDTG---LLALSRGPHVTLWK----DALKLSGDSK 352 Query: 305 TDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSL 356 + ++ +P + + + G+ K +L E +L + H IT+L Sbjct: 353 PCFGSMGGNPHRNTPYMSHLFAGN-KVENLGFVPFEDLLGV--GHQTGITNL 401 Score = 58.6 bits (140), Expect = 5e-09, Method: Composition-based stats. Identities = 30/212 (14%), Positives = 70/212 (33%), Gaps = 10/212 (4%) Query: 181 RDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKD 240 + ++ N + + + ++ G+ L + S + A A K Sbjct: 114 YHIKYAKNGTHLLITGRKGHVASMDWRKGQLRAELFLNETC-HSATYLQNEQYFAVAQKK 172 Query: 241 NLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMC 300 ++D G + + + F P LL+ + + D+ Sbjct: 173 YTF-IYD-HEGTELHRLKQHIEA-RHLDFLPYH-YLLVTAGETGWLKYHDVSTGQLVSEL 228 Query: 301 VRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNP 360 M + +P N M +G++ + ++ EP++ + A + S++ + Sbjct: 229 RTKAGPTMAMAQNPWNAVMHLGHS-NGTVSLWSP--SMPEPLVKLLSA-RGPVNSIAIDR 284 Query: 361 VGHIFATAAKDRTIRFWTRARPIDPNAYDDPT 392 G+ AT DR+++ W R + Sbjct: 285 SGYYMATTGADRSMKIWDI-RNFKQLHSVESL 315 >5WLC-LV nrPDB Length = 707 Score = 67.8 bits (164), Expect = 8e-12, Method: Composition-based stats. Identities = 44/284 (15%), Positives = 100/284 (35%), Gaps = 27/284 (9%) Query: 99 IQWTPEGRR-LVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADG 157 I+ + +G+ + TY + +++ ++ + + H A + ++ ++S D Sbjct: 62 IKVSRDGQYCMATGTYKPQIHVYDFANLSLK--FDRHTDA-ENVDFT-----ILSDDWTK 113 Query: 158 MIKIWQPNFSMVKEIDAAH-----TESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQE 212 + + + H + R + ++ + + N L N G+ Sbjct: 114 SVHLQNDRSIQFQNKGGLHYTTRIPKFGRSLVYNKVNCDLYVGASGNELYRLNLEKGRFL 173 Query: 213 RVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKH------TVLK 266 V + GL+A+ ++ N+V+ WDPRS + +S + + V Sbjct: 174 NPFKLDTEGVNHVSINEVNGLLAAGTETNVVEFWDPRSRSRVSKLYLENNIDNRPFQVTT 233 Query: 267 TRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDET-DYMTLEWHPINESMFTLACY 325 T F+ G + + ++D+R S ++ + D + W + + Sbjct: 234 TSFR-NDGLTFACGTSNGYSYIYDLRTSEPSIIKDQGYGFDIKKIIWLDNVGTENKIVTC 292 Query: 326 DGSL-KHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATA 368 D + K +D L I + + P +F TA Sbjct: 293 DKRIAKIWDRLDG----KAYASMEPSVDINDIEHVPGTGMFFTA 332 Score = 57.8 bits (138), Expect = 9e-09, Method: Composition-based stats. Identities = 31/216 (14%), Positives = 68/216 (31%), Gaps = 12/216 (5%) Query: 74 RDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQA 133 DR I +K + ++ ++ + L V E N F + Sbjct: 119 NDRSIQFQNKGGLHYTTRIPKFGRSLVYNKVNCDLYVGASGNELYRLNLEKGRFLNPFKL 178 Query: 134 HDSAVTTMKYSHDSDWMISGDADGMIKIWQPNF----SMVKEIDAAHTES--IRDMAFSS 187 V + + + + +G +++ W P S + + + +F + Sbjct: 179 DTEGVNHVSINEVNGLLAAGTETNVVEFWDPRSRSRVSKLYLENNIDNRPFQVTTTSFRN 238 Query: 188 NDSKFVTCSDDNILKIWNFSNGKQERVL-SGHHWDVKSCDWHPE---MGLIASASKDNLV 243 + F + + I++ + + G+ +D+K W I + K + Sbjct: 239 DGLTFACGTSNGYSYIYDLRTSEPSIIKDQGYGFDIKKIIWLDNVGTENKIVTCDK-RIA 297 Query: 244 KLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMA 279 K+WD G +S+ + P G A Sbjct: 298 KIWDRLDGKAYASMEPSVD-INDIEHVPGTGMFFTA 332 >5TF2-A nrPDB Length = 407 Score = 67.1 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 32/224 (14%), Positives = 62/224 (27%), Gaps = 33/224 (14%) Query: 97 PAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDAD 156 + + + L G +W S +AH+ + + D +++ D Sbjct: 176 KVVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGK-LVTVGRD 234 Query: 157 GMIKIWQPNF--SMVKEIDAA-----HTESIRDMAF-----SSNDSKFVTCSDDN----- 199 +WQ + + + + + F + T + Sbjct: 235 LKASVWQKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLFTVQIPHKRLRQ 294 Query: 200 ----ILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCI- 254 L W+ SN R S H V D + + V ++ S C+ Sbjct: 295 PPPCYLTAWDGSNFLPLRTKSCGHEVVSCLDVSESGTFLGLGTVTGSVAIYIAFSLQCLY 354 Query: 255 SSILKFKHTVLKTRFQPTKG----------NLLMAISKDKSCRV 288 V F P KG L +++ D C++ Sbjct: 355 YVREAHGIVVTDVAFLPEKGRGPELLGSHETALFSVAVDSRCQL 398 Score = 63.6 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 26/191 (13%), Positives = 60/191 (31%), Gaps = 31/191 (16%) Query: 183 MAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNL 242 + F+ +++ T D +++W + ++ H +++ P+ L + +D Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGKL-VTVGRDLK 236 Query: 243 VKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVR 302 +W + V + +Q + ++CR + L Sbjct: 237 ASVW------------QKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLFT 284 Query: 303 DETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVG 362 + + L P L +DGS P+ T H+ ++ L + G Sbjct: 285 VQIPHKRLRQPP----PCYLTAWDGSNFL---------PLRTKSCGHE-VVSCLDVSESG 330 Query: 363 HIF----ATAA 369 T + Sbjct: 331 TFLGLGTVTGS 341 Score = 43.6 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 28/202 (13%), Positives = 56/202 (27%), Gaps = 47/202 (23%) Query: 65 IMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASS 124 ++ G RV +PS L + I + P+G+ + V + + Sbjct: 186 LLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGKLVTVGR--------DLKA 237 Query: 125 FTFETLMQAHDSAVTTMKYSHDSDWMIS------------------GDADGMIKI----- 161 ++ D VT + + + S G ++I Sbjct: 238 SVWQK-----DQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLFTVQIPHKRL 292 Query: 162 ----------WQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIW-NFSNGK 210 W + + + E + + S + + + + I+ FS Sbjct: 293 RQPPPCYLTAWDGSNFLPLRTKSCGHEVVSCLDVSESGTFLGLGTVTGSVAIYIAFSLQC 352 Query: 211 QERVLSGHHWDVKSCDWHPEMG 232 V H V + PE G Sbjct: 353 LYYVREAHGIVVTDVAFLPEKG 374 Score = 38.2 bits (87), Expect = 0.008, Method: Composition-based stats. Identities = 9/60 (15%), Positives = 20/60 (33%), Gaps = 4/60 (6%) Query: 356 LSYNPVGHIFATAAKDRTIRFWTRA--RPIDPNAYDDPTYNNKKI--NGWFFGINNDINA 411 + +N + AT D +R W + + + + +G + D+ A Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGKLVTVGRDLKA 237 >5AMS-A nrPDB Length = 431 Score = 64.0 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 34/222 (15%), Positives = 68/222 (30%), Gaps = 21/222 (9%) Query: 176 HTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNG--KQERVLSGHHWDVKSCDWHPEMGL 233 HT+S+ + N T DN+ +W + K L+G+ V SC + E G Sbjct: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGF 123 Query: 234 IASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNL---LMAISKDKSCRVFD 290 + +A V + + G + V + + T + + D S + Sbjct: 124 LVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQ 183 Query: 291 IRYSMKELMCVR----DETDYMTLEWHPINES----MFTLACYDGSLKHFDLLQNLNEPI 342 I L + + D E+ ++ D ++ ++ Sbjct: 184 INEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFK 243 Query: 343 LT--IPYAHDKCITSLSYNPV------GHIFATAAKDRTIRF 376 +T + SLS P + A + + + Sbjct: 244 ITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAV 285 Score = 63.6 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 32/182 (17%), Positives = 59/182 (32%), Gaps = 12/182 (6%) Query: 208 NGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSG--NCISSILKFKHTVL 265 + H V + HP + L+ + DNL LW S ++ + +V+ Sbjct: 54 SNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVI 113 Query: 266 KTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEW---HPINESMFTL 322 F ++G L+ V + + + + W HP F Sbjct: 114 SCSFT-SEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAF 172 Query: 323 ACYDGSLKHFDL-LQNLNEPILTIPYAHDKCITSLSY--NPVGH---IFATAAKDRTIRF 376 DGS+ + + Q+ + L + H + + + G T + D TI Sbjct: 173 GATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVA 232 Query: 377 WT 378 W Sbjct: 233 WN 234 Score = 62.8 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 37/313 (11%), Positives = 98/313 (31%), Gaps = 41/313 (13%) Query: 91 KVKHVIPAIQWTPEGRRLVVATYSGEFSLW--NASSFTFETLMQAHDSAVTTMKYSHDSD 148 K + AI P + LW ++ F + + +V + ++ + Sbjct: 63 KHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGG 122 Query: 149 WMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSND----SKFVTCSDDNILKIW 204 ++++ D G + + + A+ + + ++ + F + D + + Sbjct: 123 FLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCY 182 Query: 205 --NFSNGKQERVLSG--HHWDVKSCDWHP-----EMGLIASASKDNLVKLWDPRSGNCI- 254 N +G E+++SG H D ++ + + S D+ + W+ +G + Sbjct: 183 QINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLF 242 Query: 255 ----SSILKFKHTVLKTRFQPT-----KGNLLMAISKDKSCRVFDIRYSMKELMCVR--- 302 + I + + P ++ S + V + L Sbjct: 243 KITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLSTVIE 302 Query: 303 -------DETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITS 355 + ++ W S+ + G + +D + + +T Sbjct: 303 LKPEQDELDASIESISWSS-KFSLMAIGLVCGEILLYDTSAWRVRHKFVL----EDSVTK 357 Query: 356 LSYNPVGHIFATA 368 L ++ +FA+ Sbjct: 358 LMFDND-DLFASC 369 Score = 61.7 bits (148), Expect = 6e-10, Method: Composition-based stats. Identities = 44/290 (15%), Positives = 86/290 (29%), Gaps = 35/290 (12%) Query: 124 SFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKE--IDAAHTESIR 181 S T H +V + + + + +G D + +W + K + ES+ Sbjct: 54 SNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVI 113 Query: 182 DMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDW---HPE-MGLIASA 237 +F+S VT + + G + L+ +V+ W HP A Sbjct: 114 SCSFTSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFG 173 Query: 238 SKDNLVKLWDPR------SGNCISSILKFKHTVLKTRFQPTKGN----LLMAISKDKSCR 287 + D V W + S + S + F T L+ S D + Sbjct: 174 ATDGSV--WCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIV 231 Query: 288 VFDIRYSMKELMCVRD-----ETDYMTLEWHPI-----NESMFTLACYDGSLKHFDLLQN 337 ++ + + E +++L P N + +G L + Sbjct: 232 AWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNG 291 Query: 338 LNEPILTI-------PYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRA 380 L+ D I S+S++ + A I + + Sbjct: 292 GAILHLSTVIELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYDTS 341 Score = 41.7 bits (96), Expect = 6e-04, Method: Composition-based stats. Identities = 34/223 (15%), Positives = 77/223 (34%), Gaps = 40/223 (17%) Query: 14 QIQQSQQPPLKKY----------VTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTI 63 + S + + +TQ + +P+I+L P + + + Sbjct: 221 LVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSL-----APETLTKGNSG--- 272 Query: 64 DIMPPNAYRGRDRVINLPS--KFTHLSSN--------KVKHVIPAIQWTPEGRRLVVATY 113 ++ + G VIN + HLS+ ++ I +I W+ + + + Sbjct: 273 -VVACGSNNGLLAVINCNNGGAILHLSTVIELKPEQDELDASIESISWSSKFSLMAIGLV 331 Query: 114 SGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEID 173 GE L++ S++ DS VT + + +D + + +G + + K + Sbjct: 332 CGEILLYDTSAWRVRHKFVLEDS-VTKLMFDNDD--LFASCINGKVYQFNARTGQEKFVC 388 Query: 174 AAHTESIRD-MAFSS-------NDSKFVTCSDDNILKIWNFSN 208 H + D + K +T D+ + ++ N Sbjct: 389 VGHNMGVLDFILLHPVANTGTEQKRKVITAGDEGVSLVFEVPN 431 >2I3T-A nrPDB Length = 341 Score = 63.2 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 35/284 (12%), Positives = 90/284 (31%), Gaps = 29/284 (10%) Query: 126 TFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFS-----MVKEIDAAHTESI 180 + QA ++ +K ++ DG + +++ + +++ + H + Sbjct: 2 QIVQIEQAPKDYISDIKIIPSKSLLLITSWDGSLTVYKFDIQAKNVDLLQSLRYKH--PL 59 Query: 181 RDMAF-SSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGL-IASAS 238 F + D + + + + + L+ + ++ C + +AS Sbjct: 60 LCCNFIDNTDLQIYVGTVQGEILKVDLIGSPSFQALTNNEANLGICRICKYGDDKLIAAS 119 Query: 239 KDNLVKLWDPRS-GNCISSILKFKHTVLKTR----FQPTKGNLLMAISKDKSCRVFDIRY 293 D L+++ DPR+ G+ + ++ K + T + L+ + + F + Sbjct: 120 WDGLIEVIDPRNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVGMNNSQVQWFRLPL 179 Query: 294 SMKELMCVRDET---DYMTLEWHPINESMFTLACYDGSLKHF---DLLQNLNEPILTIPY 347 + + + + P + + + DG + D + N Sbjct: 180 CEDDNGTIEESGLKYQIRDVALLPKEQEGYACSSIDGRVAVEFFDDQGDDYNSSKRFAFR 239 Query: 348 AH---------DKCITSLSYNPVGHIFATAAKDRTIRFWTRARP 382 H + S+ ++P TA D I W Sbjct: 240 CHRLNLKDTNLAYPVNSIEFSPRHKFLYTAGSDGIISCWNLQTR 283 Score = 56.3 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 45/301 (14%), Positives = 106/301 (35%), Gaps = 43/301 (14%) Query: 14 QIQQSQQPPLKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRG 73 + S L Y D+ + ++L + R+ P L+ T + +G Sbjct: 26 LLITSWDGSLTVY-----KFDIQAKNVDLLQSLRYKHP-LLCCNFIDNTDLQIYVGTVQG 79 Query: 74 RDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGR-RLVVATYSGEFSLWNASSF----TFE 128 ++L + + + + + G +L+ A++ G + + ++ Sbjct: 80 EILKVDLIGSPSFQALTNNEANLGICRICKYGDDKLIAASWDGLIEVIDPRNYGDGVIAV 139 Query: 129 TLMQAHDSAVTTMKYSHD--SDWMISGDADGMIKIW-------QPNFSMVKEIDAAHTES 179 + ++++ V ++ D S +I G + ++ W N ++ + Sbjct: 140 KNLNSNNTKVKNKIFTMDTNSSRLIVGMNNSQVQ-WFRLPLCEDDNGTIEES---GLKYQ 195 Query: 180 IRDMAFSSNDSKFVTCSD-DNILKI---------------WNFSNGKQERVLSGHHWDVK 223 IRD+A + + CS D + + + F + + + V Sbjct: 196 IRDVALLPKEQEGYACSSIDGRVAVEFFDDQGDDYNSSKRFAFRCHRLNLKDTNLAYPVN 255 Query: 224 SCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFK-HTVLKTRFQPTKGNLLMAISK 282 S ++ P + +A D ++ W+ ++ I + KF +V+K L +A S Sbjct: 256 SIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKNFAKFNEDSVVKIACS--DNILCLATSD 313 Query: 283 D 283 D Sbjct: 314 D 314 >5LTD-A nrPDB Length = 525 Score = 62.8 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 17/142 (11%), Positives = 53/142 (37%), Gaps = 11/142 (7%) Query: 82 SKFTHLSSNKVK----HVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSA 137 S+ +L+ + + + + + +G+ +++A + ++++AH ++ Sbjct: 169 SENNYLAYPSPQKLAPNPQTEVTLHSNPQTV----RNGDVIIFDAKTLQPTSVIEAHRTS 224 Query: 138 VTTMKYSHDSDWMISGDADGM-IKIWQPNFSMVKEIDAAHTES--IRDMAFSSNDSKFVT 194 + + S D + + G I+++ + T I +AFS ++ + Sbjct: 225 LAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQFRRGTYPTKIYSLAFSPDNRFVIA 284 Query: 195 CSDDNILKIWNFSNGKQERVLS 216 S + I+ + + Sbjct: 285 SSATETVHIFRLGEEEAANTIK 306 Score = 62.1 bits (149), Expect = 5e-10, Method: Composition-based stats. Identities = 20/129 (15%), Positives = 47/129 (36%), Gaps = 3/129 (2%) Query: 37 SPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVI 96 SP Y L P+T T+ P G + + + + + Sbjct: 166 SPSSENNYLAYPSPQKLAPNPQTEVTLHSNPQTVRNGDVIIFDAKTLQPTSVIEAHRTSL 225 Query: 97 PAIQWTPEGRRLVVATYSGE-FSLWNASSFTFETLMQAHD--SAVTTMKYSHDSDWMISG 153 AI + +G L A+ G +++ ++ + + + ++ +S D+ ++I+ Sbjct: 226 AAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQFRRGTYPTKIYSLAFSPDNRFVIAS 285 Query: 154 DADGMIKIW 162 A + I+ Sbjct: 286 SATETVHIF 294 Score = 52.4 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 16/181 (8%), Positives = 59/181 (32%), Gaps = 27/181 (14%) Query: 116 EFSLWNASSFTFETLMQAHDSAVTTMKYSHD--SDWMISGDADGMIKIWQPNFSMVKEID 173 +++ ++ ++ + + S ++++ + PN + Sbjct: 138 TIYIYDINNMRLLHTIETPSNPNGLIALSPSSENNYLAYPSPQKLA----PNPQTEVTL- 192 Query: 174 AAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGL 233 H+ + + I++ + V+ H + + + L Sbjct: 193 --HSNPQTV--------------RNGDVIIFDAKTLQPTSVIEAHRTSLAAIALSKDGLL 236 Query: 234 IASASKDNL-VKLWDPRSGNCISSILKFKHT--VLKTRFQPTKGNLLMAISKDKSCRVFD 290 +A+AS ++++ +G + + + + F P ++ + S ++ +F Sbjct: 237 LATASDKGTIIRVFSVATGIKLYQFRRGTYPTKIYSLAFSPDNRFVIAS-SATETVHIFR 295 Query: 291 I 291 + Sbjct: 296 L 296 Score = 49.0 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 35/276 (12%), Positives = 85/276 (30%), Gaps = 35/276 (12%) Query: 135 DSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVT 194 + + ++ D + G ++G KI+ + + I +M FSS+ V Sbjct: 31 NDNINFANFNQDFSCVSVGYSNG-YKIYNCEPFGQCYSKSDGSIGIVEMLFSSSLLAIVG 89 Query: 195 CSDDNIL-----KIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPR 249 + + L KI N L+ + + + E ++ + + ++D Sbjct: 90 MGEQHSLSPRRLKIINTKRQTTICELTF-PGAILAVKLNRERLVVL---LEETIYIYDIN 145 Query: 250 SGNCISSILKFKHTVLKTRFQPT-KGNLLMAIS---------------------KDKSCR 287 + + +I + P+ + N L S ++ Sbjct: 146 NMRLLHTIETPSNPNGLIALSPSSENNYLAYPSPQKLAPNPQTEVTLHSNPQTVRNGDVI 205 Query: 288 VFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSL-KHFDLLQNLNEPILTIP 346 +FD + + T + + + A G++ + F + + Sbjct: 206 IFDAKTLQPTSVIEAHRTSLAAIALS-KDGLLLATASDKGTIIRVFSVATGIKLYQFRRG 264 Query: 347 YAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARP 382 K I SL+++P ++ T+ + Sbjct: 265 TYPTK-IYSLAFSPDNRFVIASSATETVHIFRLGEE 299 Score = 30.5 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 6/61 (9%), Positives = 27/61 (44%), Gaps = 3/61 (4%) Query: 65 IMPPNAYRGRD-RVINLPSKFTHLSSNKVKHV--IPAIQWTPEGRRLVVATYSGEFSLWN 121 ++ + +G RV ++ + + + I ++ ++P+ R ++ ++ + ++ Sbjct: 236 LLATASDKGTIIRVFSVATGIKLYQFRRGTYPTKIYSLAFSPDNRFVIASSATETVHIFR 295 Query: 122 A 122 Sbjct: 296 L 296 >6IYY-A nrPDB Length = 317 Score = 62.1 bits (149), Expect = 5e-10, Method: Composition-based stats. Identities = 30/237 (12%), Positives = 81/237 (34%), Gaps = 17/237 (7%) Query: 107 RLVVATYSGEFSLWNASSFTFETLMQAH-DSAVTTMKYSHDSDWMISGDADGMIKIWQ-- 163 +V + +W+ +T+++ + V +K D ++ D MIK++ Sbjct: 63 LALVGGGKKKVMIWD--DLKKKTVIEIEFSTEVKAVKLRRDRIVVV---LDSMIKVFTFT 117 Query: 164 PNFSMVKEIDAAHTESIRDMAFSSNDSKFVT--CSDDNILKIWNF-SNGKQERVLSGHHW 220 N + + + + ++++ + + +++ + S K + H Sbjct: 118 HNPHQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPPVDIPAHEG 177 Query: 221 DVKSCDWHPEMGLIASASKDNL-VKLWDPRSGNCISSILKFKHTVLKTRFQPT-KGNLLM 278 + + + IA+AS+ ++++D SG+ I + + +L+ Sbjct: 178 VLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRGSQAANIYCINFNQDASLIC 237 Query: 279 AISKDKSCRVFDIRYSMKELMCVR---DETDYMTLEWHPINESMFTLACYDGSLKHF 332 S + +F + + + ++ + C DGS F Sbjct: 238 VSSDHGTVHIFAAEDPKSKWSFSKFQVPSGSPCICAFGTEPNAVIAI-CADGSYYKF 293 Score = 57.4 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 35/210 (16%), Positives = 74/210 (35%), Gaps = 13/210 (6%) Query: 176 HTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIA 235 H + F+ + F C +N +++N K++ V + +A Sbjct: 6 HGNGLLYAGFNQDHGCFA-CGMENGFRVYNTDPLKEKEKQEFLEGGVGHVEMLFRCNYLA 64 Query: 236 -SASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYS 294 V +WD + I F V + + + +++ D +VF ++ Sbjct: 65 LVGGGKKKVMIWDDLKKKTVIEIE-FSTEVKAVKLRRDRIVVVL----DSMIKVFTFTHN 119 Query: 295 MKELMCVR---DETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDK 351 +L + L + N + + G ++ DL P+ AH+ Sbjct: 120 PHQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPPVD--IPAHEG 177 Query: 352 CITSLSYNPVGHIFATAAKDRT-IRFWTRA 380 ++ ++ N G ATA++ T IR + + Sbjct: 178 VLSCIALNLQGTRIATASEKGTLIRIFDTS 207 Score = 57.4 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 26/168 (15%), Positives = 66/168 (39%), Gaps = 9/168 (5%) Query: 54 VVEPETSYTIDIMPPNAYRGRDRVINLPS-KFTHLSSNKVKHVIPAIQWTPEGRRLVVAT 112 V+ P ++ ++ + P + G ++++L S + + + V+ I +G R+ A+ Sbjct: 137 VLCPNSNNSL-LAFPGTHTGHVQLVDLASTEKPPVDIPAHEGVLSCIALNLQGTRIATAS 195 Query: 113 YSGE-FSLWNASSFTFETLMQ--AHDSAVTTMKYSHDSDWMISGDADGMIKIW---QPNF 166 G +++ SS ++ + + + + ++ D+ + G + I+ P Sbjct: 196 EKGTLIRIFDTSSGHLIQELRRGSQAANIYCINFNQDASLICVSSDHGTVHIFAAEDPKS 255 Query: 167 SMVKEIDAAHTESIRDMAFSSN-DSKFVTCSDDNILKIWNFSNGKQER 213 + S AF + ++ C+D + K G+ R Sbjct: 256 KWSFSKFQVPSGSPCICAFGTEPNAVIAICADGSYYKFLFNPKGECIR 303 Score = 35.5 bits (80), Expect = 0.056, Method: Composition-based stats. Identities = 15/107 (14%), Positives = 38/107 (35%), Gaps = 7/107 (6%) Query: 75 DRVINLPS--KFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFE---T 129 R+ + S L I I + + + V++ G ++ A + + Sbjct: 201 IRIFDTSSGHLIQELRRGSQAANIYCINFNQDASLICVSSDHGTVHIFAAEDPKSKWSFS 260 Query: 130 LMQAHDSAVTTMKYSHDSDWMISGDADGMIK--IWQPNFSMVKEIDA 174 Q + + + + +I+ ADG ++ P ++++ A Sbjct: 261 KFQVPSGSPCICAFGTEPNAVIAICADGSYYKFLFNPKGECIRDVYA 307 >3DW8-B nrPDB Length = 447 Score = 62.1 bits (149), Expect = 5e-10, Method: Composition-based stats. Identities = 50/346 (14%), Positives = 102/346 (29%), Gaps = 105/346 (30%) Query: 136 SAVTTMKYSHDSDWMISGDADGMIKIWQPNF-----------SMVKEIDAAHTES----- 179 ++T++++H + + +GD G + I+Q V +H Sbjct: 29 DIISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLK 88 Query: 180 -------IRDMAFSS--NDSKFVTCSDDNILKIWNFSNGKQ------------------- 211 I + + N ++F+ ++D +K+W S + Sbjct: 89 SLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTT 148 Query: 212 ERVLS---------------------GHHWDVKSCDWHPEMGLIASASKDNLVKLWDP-- 248 L H + + S + + SA D + LW Sbjct: 149 VTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSA-DDLRINLWHLEI 207 Query: 249 --RSGNCISS----ILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVR 302 RS N + + + + F P N + S + R+ D+R S + Sbjct: 208 TDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSK 267 Query: 303 --------DETDYMTLEWHPINESMFTLAC-----YDG-SLKHFDLLQNLNEPILTIPYA 348 + + I++ F+ + D S+K +DL N+ + Sbjct: 268 LFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKVWDL--NMENRPVETYQV 325 Query: 349 HD------------KCITS---LSYNPVGHIFATAAKDRTIRFWTR 379 H+ CI +N + T + + R + R Sbjct: 326 HEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDR 371 Score = 50.5 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 40/251 (15%), Positives = 85/251 (33%), Gaps = 45/251 (17%) Query: 69 NAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEG-RRLVVATYSGEFSLWNASSFTF 127 DR N+ + ++ VI A ++ P V ++ G L + + Sbjct: 203 WHLEITDRSFNI-VDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASAL 261 Query: 128 ----ETLMQAHDSA------------VTTMKYSHDSDWMISGDADGMIKIWQPNF-SMVK 170 L + + ++ +K+SH +M++ D +K+W N + Sbjct: 262 CDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDY-LSVKVWDLNMENRPV 320 Query: 171 EIDAAHT------------ESIRD---MAFSSNDSKFVTCSDDNILKIWNFSNGKQERVL 215 E H + I D ++ +DS +T S +N ++++ N K++ L Sbjct: 321 ETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFD-RNTKRDITL 379 Query: 216 SGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGN 275 + K + AS + + L F +L T + P + Sbjct: 380 EASRENNKPRTVLKPRKVCASGKR---------KKDEISVDSLDFNKKILHTAWHPKENI 430 Query: 276 LLMAISKDKSC 286 + +A + + Sbjct: 431 IAVATTNNLYI 441 >5K1H-B nrPDB Length = 576 Score = 59.4 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 48/323 (14%), Positives = 110/323 (34%), Gaps = 53/323 (16%) Query: 96 IPAIQWTPEGRRLVVAT-------YSGEFSLWNASSFTFETLMQAHDSAVTTM-KYSHDS 147 + I ++P R LV + +W+ + + SA + K+SHD Sbjct: 207 VQLIDFSPCERYLVTFSPLMDTQDDPQAIIIWDILTGHKKRGFHCESSAHWPIFKWSHDG 266 Query: 148 DWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVT-CSDDNIL----- 201 + D + I++ + + + I+D ++S + +D + Sbjct: 267 KFFARMTLD-TLSIYETPSMGLLDKKSLKISGIKDFSWSPGGNIIAFWVPEDKDIPARVT 325 Query: 202 -------------KIWNFSNGKQERVLSGHHWDVKSCDWHPEMGL-IASASKDNLVKLWD 247 ++N + K +G + VK D P+ + + +++ Sbjct: 326 LMQLPSRQEIRVRNLFNVVDCKLHWQKNGDYLCVK-VDRTPKGTQGVVT-----NFEIFR 379 Query: 248 PRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDK---SCRVFDIRYSMK-ELMCVRD 303 R +++ K T++ ++P G+ + + S + ++ + K EL + D Sbjct: 380 MREKQVPVDVVEMKETIIAFAWEP-NGSKFAVLHGEAPRISVSFYHVKSNGKIELSKMFD 438 Query: 304 ETDYMTLEWHPINESMFTLA--CYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPV 361 + T+ W P + + +G+L D + A + + ++P Sbjct: 439 KQQANTIFWSPQGQFVVLAGLRSMNGALAFVDTSD-----CTVMNIAEHYMASDVEWDPT 493 Query: 362 GHIFATA-AK-----DRTIRFWT 378 G T+ + D WT Sbjct: 494 GRYVVTSVSWWSHKVDNAYWLWT 516 Score = 56.7 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 42/313 (13%), Positives = 89/313 (28%), Gaps = 47/313 (15%) Query: 89 SNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSD 148 + + ++W+P+G L G +LW F H V + +S Sbjct: 161 EERARWTETYVRWSPKGTYLATFHQRG-IALWGGEKFKQIQRFS-HQG-VQLIDFSPCER 217 Query: 149 WMISGD--ADGM-----IKIWQPNFSMVKEIDAAHTES-IRDMAFSSNDSKFVTCSDDNI 200 ++++ D I IW K + + +S + F + D Sbjct: 218 YLVTFSPLMDTQDDPQAIIIWDILTGHKKRGFHCESSAHWPIFKWSHDGKFFARMTLD-T 276 Query: 201 LKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW-----DPRSGNCIS 255 L I+ + S +K W P +IA W D + + Sbjct: 277 LSIYETPSMGLLDKKSLKISGIKDFSWSPGGNIIA---------FWVPEDKDIPARVTLM 327 Query: 256 SILKFKH-------TVLKTRFQPTKGNLLMAISKDKSCR----------VFDIRYSMKEL 298 + + V+ + K + + D++ + +F +R + Sbjct: 328 QLPSRQEIRVRNLFNVVDCKLHWQKNGDYLCVKVDRTPKGTQGVVTNFEIFRMREKQVPV 387 Query: 299 MCVRDETDYMTLEWHPINESMFTLACYDGSLKH--FDLLQNLNEPILTIPYAHDKCITSL 356 V + + W P L + + + N + + ++ Sbjct: 388 DVVEMKETIIAFAWEPNGSKFAVLHGEAPRISVSFYHVKSNGKIELSKMFDKQQA--NTI 445 Query: 357 SYNPVGHIFATAA 369 ++P G A Sbjct: 446 FWSPQGQFVVLAG 458 Score = 39.7 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 35/212 (16%), Positives = 67/212 (31%), Gaps = 17/212 (8%) Query: 162 WQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWD 221 W + D + + A + + S D WN + W Sbjct: 110 WDIPEKQPFK-DLGNLRYWLEEAECRDQYSVIFESGDRTSIFWN-DVKDPVSIEERARWT 167 Query: 222 VKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHT-VLKTRFQPTKGNLL-MA 279 W P+ +A+ + LW G I +F H V F P + L+ + Sbjct: 168 ETYVRWSPKGTYLATF-HQRGIALW---GGEKFKQIQRFSHQGVQLIDFSPCERYLVTFS 223 Query: 280 ISKD-----KSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDL 334 D ++ ++DI K+ + + + + + F D +L ++ Sbjct: 224 PLMDTQDDPQAIIIWDILTGHKKRGFHCESSAHWPIFKWSHDGKFFARMTLD-TLSIYET 282 Query: 335 LQNLNEPILTIPYAHDKCITSLSYNPVGHIFA 366 + +L I S++P G+I A Sbjct: 283 ---PSMGLLDKKSLKISGIKDFSWSPGGNIIA 311 >5WLC-LH nrPDB Length = 896 Score = 56.7 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 46/319 (14%), Positives = 111/319 (34%), Gaps = 70/319 (21%) Query: 95 VIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGD 154 + ++ G++L V SG S+ + + L++ H +V ++ +SHD +++SG Sbjct: 258 YVSSMAIDNMGQQLAVGFASGVISIVSLADLQI-RLLKWHIDSVLSLSFSHDGSYLLSGG 316 Query: 155 ADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERV 214 + ++ +WQ + + + + I + + Sbjct: 317 WEKVMSLWQLETNSQQFLPRLNGIIIDCQVLGPQGNYY-----------------SLILQ 359 Query: 215 LSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKG 274 ++ ++ + + + + D KL + + F T+ + Sbjct: 360 MTENNS-------NSDYQFLLLNASDLTSKL------SINGPLPVFNSTIKHIQ------ 400 Query: 275 NLLMAISKDKSCRVFDIRYSMK----ELMCVRDETDYMTLEWHPINESMFTLACYDGSLK 330 + A++ S + + +S K +L+ R + +E +PIN++++ +++ Sbjct: 401 QPISAMNTKNSNSITSLNHSKKKQSRKLIKSRRQDFTTNVEINPINKNLYFPHIS--AVQ 458 Query: 331 HFDLLQNLNEPILTIPYA--------------HDKCITSLSYNPVGHIFAT--------- 367 FD +N + D IT L + G T Sbjct: 459 IFDFYKNEQVNYQYLTSGVNNSMGKVRFELNLQDPIITDLKFTKDGQWMITYEIEYPPND 518 Query: 368 --AAKD--RTIRFWTRARP 382 ++KD ++FWT+ Sbjct: 519 LLSSKDLTHILKFWTKNDN 537 Score = 48.2 bits (113), Expect = 7e-06, Method: Composition-based stats. Identities = 51/435 (11%), Positives = 136/435 (31%), Gaps = 72/435 (16%) Query: 35 VSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKH 94 +SS +L YN R+ V + G +++L + Sbjct: 245 LSSQTQSLSYNTRY-----VSSMAIDNMGQQLAVGFASGVISIVSL-ADLQIRLLKWHID 298 Query: 95 VIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDW----- 149 + ++ ++ +G L+ + SLW + + + L + + + ++ Sbjct: 299 SVLSLSFSHDGSYLLSGGWEKVMSLWQLETNSQQFLPRLNGIIIDCQVLGPQGNYYSLIL 358 Query: 150 -------------MISGDAD--------GMIKIWQPNFSMVKEIDAA----HTESIRDMA 184 ++ +D G + ++ +++ +A ++ SI + Sbjct: 359 QMTENNSNSDYQFLLLNASDLTSKLSINGPLPVFNSTIKHIQQPISAMNTKNSNSITSLN 418 Query: 185 FS---SNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEM----GLIASA 237 S + + D + N + + H V+ D++ + S Sbjct: 419 HSKKKQSRKLIKSRRQDFTTNV--EINPINKNLYFPHISAVQIFDFYKNEQVNYQYLTSG 476 Query: 238 SKD--NLVKLWDPRSGNCISS---ILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVF--- 289 + V+ + + I + K ++ + +LL + + + Sbjct: 477 VNNSMGKVRF-ELNLQDPIITDLKFTKDGQWMITYEIEYPPNDLLSSKDLTHILKFWTKN 535 Query: 290 --DIRYSMKELMCVRDETDYMTLEWHPINESM-----FTLACYDGSLKHFDLLQNLNEPI 342 + +++K + + P S+ A +G LK + + + Sbjct: 536 DNETNWNLKTKVINPHGISVPITKILPSPRSVNNSQGCLTADNNGGLKFWSFDSHESNWC 595 Query: 343 LTIP----YAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKI 398 L + H SL+++ G + D+ ++ D + N K + Sbjct: 596 LKKISLPNFNHFSNSVSLAWSQDGSLIFHGFDDK-LQILD----FDTFKKFESLENTKTV 650 Query: 399 NGWFFGINNDINAVR 413 + F ++++I V+ Sbjct: 651 S--EFTLDSEIQTVK 663 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 33/233 (14%), Positives = 78/233 (33%), Gaps = 37/233 (15%) Query: 125 FTFETLMQAHDSAVTTMKYSHDSDWMIS-----------GDAD--GMIKIW-----QPNF 166 + D +T +K++ D WMI+ D ++K W + N+ Sbjct: 482 GKVRFELNLQDPIITDLKFTKDGQWMITYEIEYPPNDLLSSKDLTHILKFWTKNDNETNW 541 Query: 167 SMVKEIDAAHTESIRDMAFSS------NDSKFVTCSDDNILKIWNFSNGK-------QER 213 ++ ++ H S+ N +T ++ LK W+F + + Sbjct: 542 NLKTKVINPHGISVPITKILPSPRSVNNSQGCLTADNNGGLKFWSFDSHESNWCLKKISL 601 Query: 214 VLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTK 273 H + S W + LI D+ +++ D + ++T + F Sbjct: 602 PNFNHFSNSVSLAWSQDGSLIFHG-FDDKLQILDFDT---FKKFESLENTKTVSEFTLDS 657 Query: 274 GNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYD 326 + + D + + R ++ + +R + + + +P ++ D Sbjct: 658 EIQTVKLINDTNL-IVATRTTLNAINLLRGQV-INSFDLYPFVNGVYKNGHMD 708 Score = 39.7 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 22/179 (12%), Positives = 53/179 (29%), Gaps = 26/179 (14%) Query: 168 MVKEIDAAHTESIRDMAFS---SNDSKFVTCSDD-----------NILKIWNFSNG---- 209 K+ + AH ++ S SN D +++ +++ S Sbjct: 181 AKKQFEVAHQAEWHNVILSNISSNGKLLAHMCKDVSTKDHEHKSISVVSLFDDSVNLSFP 240 Query: 210 ------KQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHT 263 Q + LS + V S +A ++ + I + + Sbjct: 241 LGSILSSQTQSLSYNTRYVSSMAIDNMGQQLAVGFASGVISIVSLADLQ-IRLLKWHIDS 299 Query: 264 VLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTL 322 VL F G+ L++ +K ++ + + ++ + + P + Sbjct: 300 VLSLSFS-HDGSYLLSGGWEKVMSLWQLETNSQQFLPRLNGIIIDCQVLGPQGNYYSLI 357 >5WLC-LS nrPDB Length = 594 Score = 56.3 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 24/152 (15%), Positives = 47/152 (30%), Gaps = 16/152 (10%) Query: 115 GEFSLWNASSFTFETLMQ---AHDSAVTTMKYSH--DSDWMISGDADGMIKIWQPNFSMV 169 W T +Q + ++ S + W+ G G + ++ N +M Sbjct: 442 HVIRRWKDQGGVGITKIQVGGGTTTTCPALQISKIKQNRWLAVGSESGFVNLYDRNNAMT 501 Query: 170 KEIDA------AHTESIRDMAFSSNDSKFVTCSDD-----NILKIWNFSNGKQERVLSGH 218 T +I ++ FS + S ++ + + S Sbjct: 502 SSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAVKDALRLVHLPSCSVFSNWPTSGTP 561 Query: 219 HWDVKSCDWHPEMGLIASASKDNLVKLWDPRS 250 V S + P GL+A ++ V+LW Sbjct: 562 LGKVTSVAFSPSGGLLAVGNEQGKVRLWKLNH 593 Score = 55.9 bits (133), Expect = 4e-08, Method: Composition-based stats. Identities = 41/352 (11%), Positives = 97/352 (27%), Gaps = 75/352 (21%) Query: 94 HVIPAIQWTPEGRRLVVATYSGEFSLW--NASSFTFETLMQAHDSAVTTMKY-----SHD 146 I ++ + P L+ Y ++ + + T + S + T + + + Sbjct: 249 SAIQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFYTSLSNQN 308 Query: 147 SDWMISGDADGMIKIWQPNFSMVKEIDA----------AH-------------------T 177 + + + W + + H T Sbjct: 309 QQNIFTAGRRRYMHSWDLSLENLTHSQTAKIEKFSRLYGHESTQRSFENFKVAHLQNSQT 368 Query: 178 ESIRDMA------------FSSNDSKFVTCSDDNILKIW-----NFSNGKQERVLSG--H 218 S+ + S++ + C + ++ + S GK +L Sbjct: 369 NSVHGIVLLQGNNGWINILHSTSGLWLMGCKIEGVITDFCIDYQPISRGKFRTILIAVNA 428 Query: 219 HWDVKSCDWHPEMGLIASASKDNLVKLWDPRSG---NCISSILKFKHTVLKTRFQPTKGN 275 + +V D + + ++ W + G I T + K N Sbjct: 429 YGEVWEFDLNKNGHV---------IRRWKDQGGVGITKIQVGGGTTTTCPALQISKIKQN 479 Query: 276 L-LMAISKDKSCRVFDIRYSMKELMCV------RDETDYMTLEWHPINESMFTLA-CYDG 327 L S+ ++D +M + T L++ P + + + Sbjct: 480 RWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAVKD 539 Query: 328 SLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTR 379 +L+ L +TS++++P G + A + +R W Sbjct: 540 ALRLVHLPSCSVFSNWPTSGTPLGKVTSVAFSPSGGLLAVGNEQGKVRLWKL 591 Score = 47.0 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 18/114 (15%), Positives = 47/114 (41%), Gaps = 11/114 (9%) Query: 106 RRLVVATYSGEFSLWN------ASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDA---D 156 R L V + SG +L++ +S+ T + + ++ +++S D + D Sbjct: 480 RWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAVKD 539 Query: 157 GMIKIWQPNFSMVKEIDAAHT--ESIRDMAFSSNDSKFVTCSDDNILKIWNFSN 208 + + P+ S+ + T + +AFS + ++ +++W ++ Sbjct: 540 ALRLVHLPSCSVFSNWPTSGTPLGKVTSVAFSPSGGLLAVGNEQGKVRLWKLNH 593 Score = 47.0 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 15/82 (18%), Positives = 36/82 (43%), Gaps = 5/82 (6%) Query: 91 KVKHVIPAIQWTPEGRRLVVATY--SGEFSLWNASSFTFET---LMQAHDSAVTTMKYSH 145 ++ I +Q++P+G+ L +A+ L + S + + VT++ +S Sbjct: 513 QLTTTISNLQFSPDGQILCMASRAVKDALRLVHLPSCSVFSNWPTSGTPLGKVTSVAFSP 572 Query: 146 DSDWMISGDADGMIKIWQPNFS 167 + G+ G +++W+ N Sbjct: 573 SGGLLAVGNEQGKVRLWKLNHY 594 >6CVZ-A nrPDB Length = 351 Score = 56.3 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 39/268 (14%), Positives = 83/268 (30%), Gaps = 36/268 (13%) Query: 159 IKIWQPNFSMVKEIDAAHTESIRDMAFSSN-DSKFVTCSDDNILKIWNFSNGKQERVLSG 217 +K+ + H + IR +AFSS ++ S DN +K+ + + + Sbjct: 56 VKMLSTANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNA 115 Query: 218 HHWDVKSCDW-HPEMGLIASASKDNLVKLWDPR-SGNCISSILKFKH--TVLKTRFQPTK 273 V SC W E I + + + ++D R + + + ++ K ++ + P Sbjct: 116 -GRPVWSCCWCLDEANYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMPRA 174 Query: 274 -------GNLLMAISKDKS-----------CRVFDIRYSMKELMCVRDETDYMTLEWHPI 315 G +L +D S V + + + + + + P Sbjct: 175 ASAAFPYGGVLAGTLEDASFWEQKMDFSHWPHVLPLEPGGCIDFQTENSSRHCLVTYRPD 234 Query: 316 NESMFTLACYDGSLKHFDLLQNL---NEPILTIPYAHDKCI---TSLSYNP--VGHIFAT 367 + D N +P+ T + ++ +P G+I Sbjct: 235 KNHTTIRSVLMEMSYRLDDTGNPICSCQPVHTFFGGPTCKLLTKNAIFQSPENDGNILVC 294 Query: 368 AAKD--RTIRFWTRARP--IDPNAYDDP 391 + + W A + D P Sbjct: 295 TGDEAANSALLWDAASGSLLQDLQTDQP 322 Score = 45.1 bits (105), Expect = 7e-05, Method: Composition-based stats. Identities = 30/270 (11%), Positives = 71/270 (26%), Gaps = 43/270 (15%) Query: 117 FSLWNASSFTFETLMQAHDSAVTTMKYSHD-SDWMISGDADGMIKIWQPNFSMVKEIDAA 175 + + ++ + H + + +S ++S D IK+ + V + A Sbjct: 56 VKMLSTANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNA 115 Query: 176 HTESIRDMAFSSNDSKFVTCSDDNILKIWNFS-NGKQERVLSGHHW--DVKSCDWHPE-- 230 + + + +++ + L + S + P Sbjct: 116 GRPVWSCCWCLDEANYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMPRAA 175 Query: 231 ------MGLIASASKDNLVKLWD-------------PRSGNCI--SSILKFKHTVLKTRF 269 G++A +D W+ G CI + +H + + Sbjct: 176 SAAFPYGGVLAGTLED--ASFWEQKMDFSHWPHVLPLEPGGCIDFQTENSSRHCL--VTY 231 Query: 270 QPT-KGNLLMAISKDKSCRVFDIRYSMKELMCVRDETD--------YMTLEWHPINESMF 320 +P + ++ + S R+ D + V + P N+ Sbjct: 232 RPDKNHTTIRSVLMEMSYRLDDTGNPICSCQPVHTFFGGPTCKLLTKNAIFQSPENDGNI 291 Query: 321 TLACYD---GSLKHFDLLQNLNEPILTIPY 347 + D S +D L Sbjct: 292 LVCTGDEAANSALLWDAASGSLLQDLQTDQ 321 Score = 44.0 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 13/74 (17%), Positives = 31/74 (41%), Gaps = 3/74 (4%) Query: 96 IPAIQWTPEGR-RLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHD-SDWMISG 153 I + ++ R L+ A+ L + + T A V + + D ++++ +G Sbjct: 77 IRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNAGR-PVWSCCWCLDEANYIYAG 135 Query: 154 DADGMIKIWQPNFS 167 A+G I ++ + Sbjct: 136 LANGSILVYDVRNT 149 Score = 36.6 bits (83), Expect = 0.025, Method: Composition-based stats. Identities = 35/296 (11%), Positives = 86/296 (29%), Gaps = 49/296 (16%) Query: 36 SSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHV 95 SS YI ++ + GL +SY ++ + ++ +L + + N + Sbjct: 66 SSQYIPMHGKQIRGL------AFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNAGR-P 118 Query: 96 IPAIQWTPEG-RRLVVATYSGEFSLWNAS-SFTFETLMQAHDSAVTTMKYS--------- 144 + + W + + +G +++ + + + A + + S Sbjct: 119 VWSCCWCLDEANYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMPRAASAA 178 Query: 145 -HDSDWMISGDADGMIKIWQ-------------PNFSMVKEIDAAHTESIRDMAFSSNDS 190 + D W+ + ++ + + + + Sbjct: 179 FPYGGVLAGTLEDAS--FWEQKMDFSHWPHVLPLEPGGCIDFQTENSSRHCLVTYRPDKN 236 Query: 191 K--FVTCSDDNILKIWNFSNG----KQERVLSG---HHWDVKSCDW-HPEM-GLIASASK 239 + + ++ + N + G K+ + PE G I + Sbjct: 237 HTTIRSVLMEMSYRLDDTGNPICSCQPVHTFFGGPTCKLLTKNAIFQSPENDGNILVCTG 296 Query: 240 D---NLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIR 292 D N LWD SG+ + + VL N +A +K ++ Sbjct: 297 DEAANSALLWDAASGSLLQDLQT-DQPVLDICPFEVNRNSYLATLTEKMVHIYKWE 351 >4FHN-A nrPDB Length = 394 Score = 55.5 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 24/129 (18%), Positives = 42/129 (32%), Gaps = 13/129 (10%) Query: 176 HTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVL-----SGHHWDVKSCD---- 226 H + DN +++ N SGHH V D Sbjct: 89 HDGDGNVNSSPVYSLFLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIADV 148 Query: 227 WHPEMGL----IASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISK 282 + + L IAS D + +W I + + +F+P+ N L+ + Sbjct: 149 YSADNRLAEQVIASVGDDCTLIIWRLTDEGPILAGYPLSSPGISVQFRPSNPNQLIVGER 208 Query: 283 DKSCRVFDI 291 + + R+FD Sbjct: 209 NGNIRIFDW 217 Score = 43.6 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 19/135 (14%), Positives = 49/135 (36%), Gaps = 14/135 (10%) Query: 218 HHWDVKSCDWHPEMGLIASA-SKDNLVKLWDPRSGNCISSIL-----KFKHTVLKTRFQP 271 H D + P L + +DN V+L ++ I+ + + V Sbjct: 89 HDGDGN-VNSSPVYSLFLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIAD 147 Query: 272 TKG-------NLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLAC 324 ++ ++ D + ++ + L + +++++ P N + + Sbjct: 148 VYSADNRLAEQVIASVGDDCTLIIWRLTDEGPILAGYPLSSPGISVQFRPSNPNQLIVGE 207 Query: 325 YDGSLKHFDLLQNLN 339 +G+++ FD NL+ Sbjct: 208 RNGNIRIFDWTLNLS 222 Score = 34.7 bits (78), Expect = 0.089, Method: Composition-based stats. Identities = 10/83 (12%), Positives = 23/83 (27%), Gaps = 10/83 (12%) Query: 310 LEWHPINESMFTLACYDGSLKHFDLLQNL--NEPILTIPYAHDKCITSLS----YNPVGH 363 + P+ C D +++ + +L H + + Y+ Sbjct: 95 VNSSPVYSLFLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIADVYSADNR 154 Query: 364 I----FATAAKDRTIRFWTRARP 382 + A+ D T+ W Sbjct: 155 LAEQVIASVGDDCTLIIWRLTDE 177 >6N8P-A nrPDB Length = 979 Score = 53.6 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 42/257 (16%), Positives = 82/257 (31%), Gaps = 35/257 (13%) Query: 83 KFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMK 142 +F + H A+ ++P R L + T SG L+ A F L Q ++AVT + Sbjct: 11 QFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQ-ENNAVTQIH 69 Query: 143 YSHDSDWMISGDADGMIKIWQP-----------NFSMVKEIDAAHTESIRDMAF---SSN 188 +++ D + +W + S S + S+ Sbjct: 70 LLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSS 129 Query: 189 DSKFVTCSDDNILKIWNF-----------SNGKQERVLSG---H---HWDVKSCDWHP-E 230 ++ + + S+ + L H V++ HP + Sbjct: 130 CELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEMVEALQEHPRD 189 Query: 231 MGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFD 290 I LV +WD + + L + L+ + G LL++ D S + Sbjct: 190 PNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQ--LENIWWQRDGRLLVSCHSDGSYCQWP 247 Query: 291 IRYSMKELMCVRDETDY 307 + ++ +R Y Sbjct: 248 VSSEAQQPEPLRSLVPY 264 Score = 49.4 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 50/436 (11%), Positives = 116/436 (26%), Gaps = 100/436 (22%) Query: 41 NLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQ 100 HG P+ S ++ I+ G ++ P + ++ + + I Sbjct: 11 QFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPG-VEFMGLHQENNAVTQIH 69 Query: 101 WTPEGRRLVVATYSGEFSLWNAS----SFTFET----LMQAHDSAVTTMKY--------- 143 P +LV LW+ + + ++ A + Sbjct: 70 LLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSS 129 Query: 144 -------SHDSDWMIS------GDADGMIKIWQPNFSMVKEIDAAHTES---IRDMAFSS 187 + + + D I +A H + + Sbjct: 130 CELLYLGTESGNVFVVQLPAFRALEDRTIS--SDAVLQRLPEEARHRRVFEMVEALQEHP 187 Query: 188 ND-SKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLW 246 D ++ + ++ IW+ + +++ W + L+ S D W Sbjct: 188 RDPNQILIGYSRGLVVIWDLQGSRVLYHFLS-SQQLENIWWQRDGRLLVSCHSDGSYCQW 246 Query: 247 DPRSG----NCISSILKFK----HTVLKTRFQPTKGNL------------------LMAI 280 S + S++ + + + + T+ L +++ Sbjct: 247 PVSSEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRHCISV 306 Query: 281 SKDKSCRVFDIRYSMKELMCVRDET----------------------DYMTLEWHPIN-E 317 D FD + + + D T W P+ Sbjct: 307 IHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEELVVIDLQTAGWPPVQLP 366 Query: 318 SMFTLACYDGSLKHF--DLLQNLNEPILTIPYAHDKCITSLSYNPVG-----------HI 364 + +L C + H ++ L E I+ + +++ + G + Sbjct: 367 YLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDL 426 Query: 365 FATAAKDRTIRFWTRA 380 T +D T+RFW + Sbjct: 427 LLTGHEDGTVRFWDAS 442 Score = 44.7 bits (104), Expect = 9e-05, Method: Composition-based stats. Identities = 37/255 (14%), Positives = 76/255 (29%), Gaps = 24/255 (9%) Query: 139 TTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAH--TESIRDMAFSSNDSKFVTCS 196 + + YS + G G IK++ E H ++ + + VT Sbjct: 25 SALGYSPSLRILAIGTRSGAIKLYGAPG---VEFMGLHQENNAVTQIHLLPGQCQLVTLL 81 Query: 197 DDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISS 256 DDN L +W+ L + + P A+ + + P S + Sbjct: 82 DDNSLHLWSLKVKGGASELQ--EDESFTLRGPPGAAPSAT-----QITVVLPHSSCELLY 134 Query: 257 ILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPIN 316 + V + + IS D + + + + L+ HP + Sbjct: 135 LGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEM-----VEALQEHPRD 189 Query: 317 ESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRF 376 + + G + +DL Q + + I + G + + D + Sbjct: 190 PNQILIGYSRGLVVIWDL-QGSRVLYHFLSSQQLENIW---WQRDGRLLVSCHSDGSYCQ 245 Query: 377 W---TRARPIDPNAY 388 W + A+ +P Sbjct: 246 WPVSSEAQQPEPLRS 260 Score = 37.0 bits (84), Expect = 0.017, Method: Composition-based stats. Identities = 27/167 (16%), Positives = 48/167 (28%), Gaps = 17/167 (10%) Query: 193 VTCSDDNI---LKIWN------FSNGKQERVLSGHHWDVKSCD-WHPEMGLIASASKDNL 242 +TCS LK+W + S P+ L+ + +D Sbjct: 376 ITCSHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGHEDGT 435 Query: 243 VKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVR 302 V+ WD SG C+ + K TV A +D+ + + Sbjct: 436 VRFWDA-SGVCLRLLYK-LSTVRVFLTDTDPNENFSAQGEDE----WPPLRKVGSFDPYS 489 Query: 303 DETDY-MTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYA 348 D+ + + +A G + +L E + A Sbjct: 490 DDPRLGIQKIFLCKYSGYLAVAGTAGQVLVLELNDEAAEQAVEQVEA 536 Score = 33.9 bits (76), Expect = 0.16, Method: Composition-based stats. Identities = 7/30 (23%), Positives = 11/30 (36%), Gaps = 1/30 (3%) Query: 103 PEGRRLVVATYSGEFSLWNASSFTFETLMQ 132 P+ L+ G W+A S L+ Sbjct: 422 PQRDLLLTGHEDGTVRFWDA-SGVCLRLLY 450 Score = 33.6 bits (75), Expect = 0.18, Method: Composition-based stats. Identities = 18/153 (11%), Positives = 38/153 (24%), Gaps = 27/153 (17%) Query: 102 TPEGRRLVVATYSGEFSLWNASSF-----TFETLMQAHDSAVTTMKYSHD------SDWM 150 T + +V E + + + L H SA+T + + + Sbjct: 335 TFDDPYALVVLAEEELVVIDLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERII 394 Query: 151 ISGDADG---MIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFS 207 +G W + +T +D ++ W+ S Sbjct: 395 AAGSRQNAHFSTMEWPIDGGTSLTPA------------PPQRDLLLTGHEDGTVRFWDAS 442 Query: 208 NGKQERVLSGHHWDVKSCDWHPEMGLIASASKD 240 + V D P ++ +D Sbjct: 443 GVCLRLLYKLSTVRVFLTDTDPNEN-FSAQGED 474 >4AV8-A nrPDB Length = 339 Score = 53.2 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 22/89 (24%), Positives = 42/89 (47%), Gaps = 3/89 (3%) Query: 130 LMQAHDSAVTTMKYSHDSDWMISGDADGM-IKIWQPNFSM-VKEIDAA-HTESIRDMAFS 186 L++AH + V ++ + D + + DG I+++Q + + V+E SI DM +S Sbjct: 174 LVKAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWS 233 Query: 187 SNDSKFVTCSDDNILKIWNFSNGKQERVL 215 + SK SD L ++ N + + Sbjct: 234 PDGSKLAVVSDKWTLHVFEVFNDAENKRH 262 Score = 45.5 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 39/303 (12%), Positives = 99/303 (32%), Gaps = 60/303 (19%) Query: 82 SKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTM 141 ++ + N V + I ++ + L+V + F ++N + D+ T+ Sbjct: 3 TRNPIVPENHVSNPIVDYEFNQDQSCLIV-STPKSFDIYNVHPLKRIMSQEMPDAG--TI 59 Query: 142 KYSHDSDWMISGDADGMIK-IWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNI 200 + H ++++ + IW + +++D+ S +F+ S ++ Sbjct: 60 RMLHRTNYIAFVSTKKELLHIWD-DVKKQDITRVKLDAAVKDLFLSR---EFIVVSQGDV 115 Query: 201 LKIWNFSN------------------------------GKQERV---------------L 215 + I+ F N G+ + Sbjct: 116 ISIFKFGNPWNKITEDIKFGGVCEFANGLLVYSNEFNLGQIHVTRLQTDAEQVVGKGVLV 175 Query: 216 SGHHWDVKSCDWHPEMGLIASASKDNL-VKLWDPRSGNCISSILKFKH--TVLKTRFQPT 272 H VK + + ++A+ S+D ++++ +G + + +++ R+ P Sbjct: 176 KAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWSP- 234 Query: 273 KGNLLMAISKDKSCRVFDIRYSMKELMCVRDE---TDYMTLEWHPINESMFTLACYDGSL 329 G+ L +S + VF++ + V + Y EW N + + Sbjct: 235 DGSKLAVVSDKWTLHVFEVFNDAENKRHVLKDWINIKYFQSEWSICNFKLKVSKGSNDCK 294 Query: 330 KHF 332 + Sbjct: 295 IAW 297 Score = 31.6 bits (70), Expect = 0.72, Method: Composition-based stats. Identities = 13/72 (18%), Positives = 27/72 (37%), Gaps = 1/72 (1%) Query: 345 IPYAHDKCITSLSYNPVGHIFATAAKDRT-IRFWTRARPIDPNAYDDPTYNNKKINGWFF 403 + AH + + N G + AT ++D T IR + + + I+ + Sbjct: 174 LVKAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWS 233 Query: 404 GINNDINAVREK 415 + + V +K Sbjct: 234 PDGSKLAVVSDK 245 Score = 29.7 bits (65), Expect = 2.8, Method: Composition-based stats. Identities = 8/81 (9%), Positives = 25/81 (30%), Gaps = 5/81 (6%) Query: 46 RRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNK--VKHVIPAIQWTP 103 + + + + + RV + + + I ++W+P Sbjct: 178 HANPVKMVRLNRKGDMVATCSQDGTL---IRVFQTDNGVLVREFRRGLDRTSIIDMRWSP 234 Query: 104 EGRRLVVATYSGEFSLWNASS 124 +G +L V + ++ + Sbjct: 235 DGSKLAVVSDKWTLHVFEVFN 255 >3WJ9-A nrPDB Length = 412 Score = 49.4 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 44/331 (13%), Positives = 96/331 (29%), Gaps = 49/331 (14%) Query: 99 IQWTPEGRRLVV---------ATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDW 149 + ++P G+ L T +WN + + ++Y+ D + Sbjct: 79 LGFSPLGKYLSTWERPGKEADGTPKQNMKVWNTETGQLVFSFVQRNQTGWNLQYTCD-ES 137 Query: 150 MISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTC------SDDNILKI 203 + + + ++ I E I D A S + V ++ Sbjct: 138 LAARLVTNEVHFYETGNMSKGPIAKLRVEGISDFALSPGQNHAVAVFIPEKKGAPASVRT 197 Query: 204 WNFSN-GKQERVLSGHHWDVKSCDWHPEMG--LIASA-----------SKDNLVKLWDPR 249 ++ N + D W+ L+ + + NL L Sbjct: 198 YSIPNFNSPLSQKTFFKADKVQFKWNALGTSLLVLTQTEVDKSNKNYYGETNLYLLGITG 257 Query: 250 SGNCISSILKFKHTVLKTRFQPTKGNL-LMAISKDKSCRVFDIRYSMKELMCVRDETDYM 308 +C + + + + + ++ +FD R ++ ++ Sbjct: 258 QFDCRVDLDR-EGPIHDVCWNADSKEFGIVYGYMPAKTAIFDNRANVVSIIPP---APRN 313 Query: 309 TLEWHPINESMFTLACYD--GSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFA 366 TL + P + + + GS+ FD N+ + I T ++P Sbjct: 314 TLIFSPNSRYILLAGFGNLQGSIDIFDAANNMKK----ITTVEAANCTYCEFSPDSQFLL 369 Query: 367 TAAK------DRTIRFWTRARPIDPNAYDDP 391 TA D +I+ W P Y++ Sbjct: 370 TAVTSPRLRVDNSIKIWHITGA--PMFYEEF 398 >2VDU-B nrPDB Length = 450 Score = 49.0 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 30/185 (16%), Positives = 64/185 (34%), Gaps = 16/185 (8%) Query: 87 LSSNKVKHVIPAIQWTPE-GRRLVVATYSGEFSLWNASSFTFETLMQAHDSAV-----TT 140 L + + I ++ T + R + A +++ T + +++ Sbjct: 96 LGAPPIYSYIRNLRLTSDESRLIACADSDKSLLVFDVDK-TSKNVLKLRKRFCFSKRPNA 154 Query: 141 MKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDA----AHTESIRDMAFSSNDS---KFV 193 + + D +I D G + N ++ H + D+ + + Sbjct: 155 ISIAEDDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFII 214 Query: 194 TCSDDNILKI-WNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGN 252 T D +KI ++ L GH V S + L+ SA D+ + WD ++G Sbjct: 215 TSDRDEHIKISHYPQCFIVDKWLFGHKHFVSSICCGKDY-LLLSAGGDDKIFAWDWKTGK 273 Query: 253 CISSI 257 +S+ Sbjct: 274 NLSTF 278 Score = 34.3 bits (77), Expect = 0.099, Method: Composition-based stats. Identities = 28/196 (14%), Positives = 59/196 (30%), Gaps = 17/196 (8%) Query: 228 HPEMGLIASASKDNLVKLWDP-RSGNCISSILK---FKHTVLKTRFQPTKGNLLMAISKD 283 E LIA A D + ++D ++ + + K F +++A K Sbjct: 112 SDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIA-DKF 170 Query: 284 KSCRVFDIRYSMKELMC---VRDETDYMT---LEWHPINESMFTLACYDGSLKHFDLLQN 337 DI +E + +T L + D +K Q Sbjct: 171 GDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQ- 229 Query: 338 LNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRF-WTRARPIDPNAYD---DPTY 393 + + H ++S+ + + D+ + W + + Y+ P Sbjct: 230 -CFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIFAWDWKTGKNLSTFDYNSLIKPYL 288 Query: 394 NNKKINGWFFGINNDI 409 N++ + F N+ Sbjct: 289 NDQHLAPPRFQNENND 304 >5WLC-LL nrPDB Length = 643 Score = 48.2 bits (113), Expect = 8e-06, Method: Composition-based stats. Identities = 48/269 (17%), Positives = 89/269 (33%), Gaps = 41/269 (15%) Query: 92 VKHVIPAIQWTPEGRRLVV-----------------ATYSGEFSLWNASSFTFETLMQAH 134 + + + P G+ L AT SG ++WN + E Sbjct: 1 MDSPVLQSAYDPSGQYLCYVTVALDKQRVGVQPTQRATSSGVDTVWNENFLYLEDS---- 56 Query: 135 DSAVTTMKY----SHDSDWMISGDADGMIKIWQ-PNFSMVKEIDAAHTESIRDMAFSSND 189 VT +K+ S D+ +I G +G I ++ + + ++ I+D+ N Sbjct: 57 KLKVTCLKWVNLASSDTVAIILGMNNGEIWLYSVLANEVTYKFTTGNSYEIKDIDLMGNQ 116 Query: 190 SKFVTCSDDNILKIWNFSNGKQERVLS-GHHWDVKSCDWHPEMG-----LIASASKDNLV 243 + SD ++ K + + + P L+AS S + Sbjct: 117 LWCIDSSD--AFYQFDLLQFKLLQHFRINNCVQLNKLTIVPAGDSVAQLLVASHS----I 170 Query: 244 KLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRD 303 L D + + V + + + D+ V+DI M + + V Sbjct: 171 SLIDIEEKKVVMTFPGHVSPVSTLQVITNE-FFISGAEGDRFLNVYDIHSGMTKCVLV-A 228 Query: 304 ETDYMTLEWHPINESMFTLACYDGSLKHF 332 E+D L +S+ DGSL+ F Sbjct: 229 ESDIKELSHSGQADSIAVT-TEDGSLEIF 256 Score = 42.4 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 26/128 (20%), Positives = 56/128 (43%), Gaps = 10/128 (7%) Query: 83 KFTHLSSNKVKHVIPA--IQWTPEGR---RLVVATYSGEFSLWNASSFTFETLMQAHDSA 137 +F L ++ + + + P G +L+VA++S SL + H S Sbjct: 133 QFKLLQHFRINNCVQLNKLTIVPAGDSVAQLLVASHS--ISLIDIEEKKVVMTFPGHVSP 190 Query: 138 VTTMKYSHDSDWMISGDA-DGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCS 196 V+T++ +++ ISG D + ++ + M K + A I++++ S + Sbjct: 191 VSTLQVI-TNEFFISGAEGDRFLNVYDIHSGMTKCVLVA-ESDIKELSHSGQADSIAVTT 248 Query: 197 DDNILKIW 204 +D L+I+ Sbjct: 249 EDGSLEIF 256 Score = 33.9 bits (76), Expect = 0.15, Method: Composition-based stats. Identities = 22/230 (9%), Positives = 66/230 (28%), Gaps = 41/230 (17%) Query: 177 TESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIAS 236 + A+ + + + + + V + W+ + Sbjct: 2 DSPVLQSAYDPSGQYLCYV----TVAL-DKQRVGVQPTQRATSSGVDTV-WNENFLYL-- 53 Query: 237 ASKDNLVKL----W-DPRSGNCISSILK-FKHTVLKTRFQPTKGNLLMAISKDKSCR--- 287 +D+ +K+ W + S + ++ IL + + + Sbjct: 54 --EDSKLKVTCLKWVNLASSDTVAIILGMNNGEIWLYSVLANEVTYKFTTGNSYEIKDID 111 Query: 288 -----VFDIRYS-------MKELMCVRDETDYMTLEWH-----PINESMFTLACYDGSLK 330 ++ I S + + ++ ++ + P +S+ L S+ Sbjct: 112 LMGNQLWCIDSSDAFYQFDLLQFKLLQHFRINNCVQLNKLTIVPAGDSVAQLLVASHSIS 171 Query: 331 HFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAK-DRTIRFWTR 379 D+ + ++ H +++L F + A+ DR + + Sbjct: 172 LIDIE---EKKVVMTFPGHVSPVSTLQVI-TNEFFISGAEGDRFLNVYDI 217 >5BPW-A nrPDB Length = 843 Score = 41.7 bits (96), Expect = 7e-04, Method: Composition-based stats. Identities = 17/106 (16%), Positives = 35/106 (33%), Gaps = 5/106 (4%) Query: 84 FTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLM---QAHDSAVTT 140 F + ++ I + W+P+ + +A +GE L +SF + VT Sbjct: 11 FRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTC 70 Query: 141 MKYSHDSDWMISGDAD-GMIKIWQPNFSMVKEIDAAHTESIRDMAF 185 + + D + AD I + + + M + Sbjct: 71 LAWRPDGKLLAFALADTKKIVLCDVEKPESLHSFSV-EAPVSCMHW 115 Score = 40.1 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 12/92 (13%), Positives = 28/92 (30%), Gaps = 5/92 (5%) Query: 183 MAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHW---DVKSCDWHPEMGLIASASK 239 + +S + + + ++ + + +V W P+ L+A A Sbjct: 26 LVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFALA 85 Query: 240 D-NLVKLWDPRSGNCISSILKFKHTVLKTRFQ 270 D + L D + S + V + Sbjct: 86 DTKKIVLCDVEKPESLHSF-SVEAPVSCMHWM 116 Score = 32.0 bits (71), Expect = 0.54, Method: Composition-based stats. Identities = 9/98 (9%), Positives = 26/98 (26%), Gaps = 17/98 (17%) Query: 141 MKYSHDSDWMISGDADGMI---------KIWQPNFSMVKEIDAAHTESIRDMAFSSNDSK 191 + +S D + + G + ++W + + + +A+ + Sbjct: 26 LVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPPN------ENTGKEVTCLAWRPDGKL 79 Query: 192 FVTCSDD-NILKIWNFSNGKQERVLSGHHWDVKSCDWH 228 D + + + + S V W Sbjct: 80 LAFALADTKKIVLCDVEKPESLHSFSV-EAPVSCMHWM 116 Score = 29.7 bits (65), Expect = 3.0, Method: Composition-based stats. Identities = 15/62 (24%), Positives = 22/62 (35%), Gaps = 1/62 (1%) Query: 310 LEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAA 369 L W P + + LA G + L K +T L++ P G + A A Sbjct: 26 LVWSPKRD-LIALANTAGEVLLHRLASFHRVWSFPPNENTGKEVTCLAWRPDGKLLAFAL 84 Query: 370 KD 371 D Sbjct: 85 AD 86 >3TKN-A nrPDB Length = 452 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 36/196 (18%), Positives = 68/196 (34%), Gaps = 37/196 (18%) Query: 209 GKQERVLSGHHWDVKSCDWHPEMGLIASAS--------KDNLVKLWDPRSGNCISSILKF 260 Q LS S I S+ +DN+++ ++ + + S+ Sbjct: 1 MSQSSRLSALPIFQASLSASQSPRYIFSSQNGTRIVFIQDNIIRWYNVLTDSLYHSLNFS 60 Query: 261 KHTVLKTRFQ---PTKGNLLM----------------AISKDKSCR-VFDIRYSMKELMC 300 +H VL F T G+LL + +D S + F I + + Sbjct: 61 RHLVLDDTFHVISSTSGDLLCLFNDNEIFVMEVPWGYSNVEDVSIQDAFQIFHYSIDEEE 120 Query: 301 VRDETDYMTLEWHPIN--ESMFTLACYDGSLKHFDLLQNLNEPILT-------IPYAHDK 351 V ++ + +HP + +S + D ++ FD+L + +PI+ A Sbjct: 121 VGPKSSIKKVLFHPKSYRDSCIVVLKEDDTITMFDILNSQEKPIVLNKPNNSFGLDARVN 180 Query: 352 CITSLSYNPVGHIFAT 367 IT L ++ G Sbjct: 181 DITDLEFSKDGLTLYC 196 >5BPT-A nrPDB Length = 741 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 14/100 (14%), Positives = 31/100 (31%), Gaps = 5/100 (5%) Query: 178 ESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHW---DVKSCDWHPEMGLI 234 I +A+S + + + +N ++ L + +V W P+ ++ Sbjct: 14 HEIIFLAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLPPNENTGKEVTCLAWRPDGKIL 73 Query: 235 ASASKD-NLVKLWDPRSGNCISSILKFKHTVLKTRFQPTK 273 A D V L D + S + ++ Sbjct: 74 AFGLADTKKVILCDVEKPESLHSFSLET-PISCMQWMEVN 112 Score = 40.1 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 14/76 (18%), Positives = 30/76 (39%), Gaps = 3/76 (3%) Query: 84 FTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLM---QAHDSAVTT 140 F + ++ H I + W+P+ + + +GE L ++ + + VT Sbjct: 4 FRQVGEKQLPHEIIFLAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLPPNENTGKEVTC 63 Query: 141 MKYSHDSDWMISGDAD 156 + + D + G AD Sbjct: 64 LAWRPDGKILAFGLAD 79 Score = 32.0 bits (71), Expect = 0.56, Method: Composition-based stats. Identities = 19/97 (19%), Positives = 37/97 (38%), Gaps = 4/97 (4%) Query: 219 HWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHT---VLKTRFQPTKGN 275 ++ W P+ LIA +K V L + + S+ ++T V ++P Sbjct: 13 PHEIIFLAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLPPNENTGKEVTCLAWRPDGKI 72 Query: 276 LLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEW 312 L ++ K + D+ + L ET ++W Sbjct: 73 LAFGLADTKKVILCDVEKP-ESLHSFSLETPISCMQW 108 Score = 29.7 bits (65), Expect = 2.8, Method: Composition-based stats. Identities = 15/62 (24%), Positives = 21/62 (33%), Gaps = 1/62 (1%) Query: 310 LEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAA 369 L W P + + L G + L L K +T L++ P G I A Sbjct: 19 LAWSPKRD-LIALVNKAGEVLLHRLANIQRVWSLPPNENTGKEVTCLAWRPDGKILAFGL 77 Query: 370 KD 371 D Sbjct: 78 AD 79 >4YHC-A nrPDB Length = 468 Score = 40.1 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 20/101 (19%), Positives = 36/101 (35%), Gaps = 5/101 (4%) Query: 175 AHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWD--VKSCDWHPEMG 232 H I +A S N F + D L +W+ + VLS +K+ P+ Sbjct: 28 HHQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGN 87 Query: 233 LIASASKDNLVKLWDPRSGNCISSILKFKHT--VLKTRFQP 271 ++ SKD + + + S + + L + P Sbjct: 88 YVSLFSKD-TLFILNVESPSLMLQHSYHSKPNSKLNVFWMP 127 Score = 38.2 bits (87), Expect = 0.009, Method: Composition-based stats. Identities = 15/103 (14%), Positives = 29/103 (28%), Gaps = 5/103 (4%) Query: 134 HDSAVTTMKYSHDSDWMISGDADGMIKIWQPNF--SMVKEIDAAHTESIRDMAFSSNDSK 191 H + + S + S D + +W + + +++ +A + Sbjct: 29 HQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGNY 88 Query: 192 FVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCD--WHPEMG 232 S D L I N + S H + W P Sbjct: 89 VSLFSKD-TLFILNVESPSLMLQHSYHSKPNSKLNVFWMPGTH 130 Score = 35.9 bits (81), Expect = 0.042, Method: Composition-based stats. Identities = 22/128 (17%), Positives = 38/128 (29%), Gaps = 13/128 (10%) Query: 218 HHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSG--NCISSILKFKHTVLKTRFQPTKGN 275 H D+ AS D + +WD R + S + T+ P +GN Sbjct: 29 HQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIALDP-QGN 87 Query: 276 LLMAISKDKSCRVFDIRYSMKELMCVRDETDYMT--LEWHPINES-------MFTLACYD 326 + SKD + + ++ L + W P + Sbjct: 88 YVSLFSKD-TLFILNVESPSLMLQHSYHSKPNSKLNVFWMPGTHKDDEWKNFELVVVESS 146 Query: 327 GSLKHFDL 334 G ++ F L Sbjct: 147 GEIQVFSL 154 Score = 32.0 bits (71), Expect = 0.55, Method: Composition-based stats. Identities = 8/37 (21%), Positives = 16/37 (43%) Query: 345 IPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRAR 381 +P H I ++ + FA+ DR++ W + Sbjct: 25 VPVHHQLDILKIAVSENYKTFASVGLDRSLVVWDLRQ 61 >6FYY-p nrPDB Length = 763 Score = 40.1 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 41/356 (11%), Positives = 103/356 (28%), Gaps = 68/356 (19%) Query: 78 INLP-SKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDS 136 N ++ L ++ ++++P+G L G + W +F D Sbjct: 214 WNSMFNEEDSLVESRENWSTNYVRFSPKGTYLFSYHQQG-VTAWGGPNFDRLRRFYHPD- 271 Query: 137 AVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRD-------------- 182 V S + ++++ + +I FS + + H I D Sbjct: 272 -VRNSSVSPNEKYLVTFSTEPIIVEEDNEFSPFTKKNEGHQLCIWDIASGLLMATFPVIK 330 Query: 183 --------MAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHH-WDVKSCDWHPEMGL 233 + +S ND D+++ + + + ++ + PE Sbjct: 331 SPYLKWPLVRWSYNDKYCARMVGDSLI-VHDATKNFMPLEAKALKPSGIRDFSFAPEGVK 389 Query: 234 IAS--ASKDNLVKL--WDPRSGN--CISSILKFK-----HTVLKTRFQ------PTKGNL 276 + + V L W P + N C ++I + TV + + Sbjct: 390 LQPFRNGDEPSVLLAYWTPETNNSACTATIAEVPRGRVLKTVNLVQVSNVTLHWQNQAEF 449 Query: 277 LM---------AISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYD- 326 L ++ + ++ + + V + W P T++ ++ Sbjct: 450 LCFNVERHTKSGKTQFSNLQICRLTERDIPVEKVELKDSVFEFGWEPHGNRFVTISVHEV 509 Query: 327 ---------GSLKHFDLLQNLNEPILT----IPYAHDKCITSLSYNPVGHIFATAA 369 +++ + ++ + ++S++P G A Sbjct: 510 ADMNYAIPANTIRFYAPETKEKTDVIKRWSLVKEIPKTFANTVSWSPAGRFVVVGA 565 >5GRS-A nrPDB Length = 396 Score = 38.6 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 20/101 (19%), Positives = 38/101 (37%), Gaps = 5/101 (4%) Query: 175 AHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWD--VKSCDWHPEMG 232 H I +A S N F + D L +W+ + VLS +K+ P+ Sbjct: 28 HHQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGN 87 Query: 233 LIASASKDNLVKLWDPRSGNCISSILKF--KHTVLKTRFQP 271 ++ SKD + + + S + + ++ L + P Sbjct: 88 YVSLFSKD-TLFILNVESPSLMLQHSYHCKPNSKLNVFWMP 127 Score = 36.6 bits (83), Expect = 0.021, Method: Composition-based stats. Identities = 15/103 (14%), Positives = 29/103 (28%), Gaps = 5/103 (4%) Query: 134 HDSAVTTMKYSHDSDWMISGDADGMIKIWQPNF--SMVKEIDAAHTESIRDMAFSSNDSK 191 H + + S + S D + +W + + +++ +A + Sbjct: 29 HQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGNY 88 Query: 192 FVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCD--WHPEMG 232 S D L I N + S H + W P Sbjct: 89 VSLFSKD-TLFILNVESPSLMLQHSYHCKPNSKLNVFWMPGTH 130 Score = 35.1 bits (79), Expect = 0.061, Method: Composition-based stats. Identities = 24/130 (18%), Positives = 39/130 (30%), Gaps = 17/130 (13%) Query: 218 HHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSG--NCISSILKFKHTVLKTRFQPTKGN 275 H D+ AS D + +WD R + S + T+ P +GN Sbjct: 29 HQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLVLSKEQMPRTLKAIALDP-QGN 87 Query: 276 LLMAISKDKSCRVFDIRYSMKELMCVRDE----TDYMTLEWHPINES-------MFTLAC 324 + SKD +F + LM + + W P + Sbjct: 88 YVSLFSKD---TLFILNVESPSLMLQHSYHCKPNSKLNVFWMPGTHKDDEWKNFELVVVE 144 Query: 325 YDGSLKHFDL 334 G ++ F L Sbjct: 145 SSGEIQVFSL 154 Score = 30.5 bits (67), Expect = 1.7, Method: Composition-based stats. Identities = 8/37 (21%), Positives = 15/37 (40%) Query: 345 IPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRAR 381 +P H I ++ + FA+ DR + W + Sbjct: 25 VPVHHQLDILKIAVSENYKTFASVGLDRCLVVWDLRQ 61 >4NOX-A nrPDB Length = 746 Score = 37.8 bits (86), Expect = 0.009, Method: Composition-based stats. Identities = 23/106 (21%), Positives = 35/106 (33%), Gaps = 5/106 (4%) Query: 173 DAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMG 232 + H +FV D + WN + E ++ HW W P Sbjct: 152 EKEHLRWFMADPADRGRDQFVMYRGDTVGVFWNNEKDQPENIVDRQHWTETFVQWSPLGT 211 Query: 233 LIASASKDNLVKLWDPRSGNCISSILKFKHT-VLKTRFQPTKGNLL 277 + S V+LW G S + +F H V F P + L+ Sbjct: 212 YLTSVHAQG-VQLW---GGASWSRLRRFPHPFVNLVAFSPGEKYLV 253 Score = 30.1 bits (66), Expect = 2.0, Method: Composition-based stats. Identities = 12/108 (11%), Positives = 34/108 (31%), Gaps = 8/108 (7%) Query: 282 KDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEP 341 D ++ E + R ++W P+ + ++ ++ + Sbjct: 176 GDTVGVFWNNEKDQPENIVDRQHWTETFVQWSPLGTYLTSVHA--QGVQLW----GGASW 229 Query: 342 ILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRARPIDPNAYD 389 + H + ++++P T + +R I+ P+ D Sbjct: 230 SRLRRFPHP-FVNLVAFSPGEKYLVTWS-NRPIQIPDSGHPVLTLDDD 275 >6NAU-A nrPDB Length = 334 Score = 37.0 bits (84), Expect = 0.019, Method: Composition-based stats. Identities = 31/259 (11%), Positives = 68/259 (26%), Gaps = 31/259 (11%) Query: 158 MIKIWQPNFSMVKEIDAAHTES--IRDMAFSSNDSKFVTCSDDNILKIWNFSN--GKQER 213 I +W + ++ M S N +F+ ++ + Sbjct: 17 QIHVWSLEADGKLTLVQVVDAPGQVQPMVVSPN-KEFLYVGVRPEFRVLAYRITPDNGAL 75 Query: 214 VLSG---HHWDVKSCDWHPEMGLIASASKD-NLVK---LWDPRSGNCISSILKFKHTVLK 266 +G + SAS + V L D G I+ + + Sbjct: 76 TFAGEAALPGSPTHISTDRHGRFVFSASYNQGCVSVTPLHDGLPGETITVVEGLEG-CHS 134 Query: 267 TRFQPTKGNLLMAISKDKSCRVFDIRYSM------KELMCVRDETDYMTLEWHPINESMF 320 P L + K +F + + + + +HP + + Sbjct: 135 ANISPDNRTLWVPALKQDRICLFTLSDDGFLSAQEPAEVTTVEGAGPRHMVFHPNQQYGY 194 Query: 321 TLACYDGSLKHFDLLQ-NLNEPILTIPY------AHDKCITSLSYNPVGHIFATAAKDRT 373 + + S+ ++L N + + + + P G DRT Sbjct: 195 CVNELNSSIDVWELKDPKGNIECVQTLDMMPPDFSGVRWAADIHITPDGRHLYAC--DRT 252 Query: 374 ---IRFWTRARPIDPNAYD 389 I ++ + A + Sbjct: 253 ASIITVFSVSEDGSVLAVE 271 >6IGB-A nrPDB Length = 364 Score = 37.0 bits (84), Expect = 0.020, Method: Composition-based stats. Identities = 49/320 (15%), Positives = 93/320 (29%), Gaps = 57/320 (17%) Query: 23 LKKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRD------- 75 ++ Y V P L L P+ + D Sbjct: 19 IQVYRFDGADGSVKGP---LRVAHTSNPSYLTFAPDQRTLFVVNENGRGGKGDTVGRATS 75 Query: 76 -RVINLPSKFTHLSSNKV--KHVIPAIQWTPEGRRLVVATYS----GEFSLWNAS---SF 125 R + + +S + H + + +GR L VA YS G ++ S Sbjct: 76 YRFDPISGRLQQISQVQTLADHPTYS-SLSHDGRYLFVANYSVQPEGSVAVLPVRADGSL 134 Query: 126 TFETLMQAHDSA----------VTTMKYSHDSDWMISG--DADGMIKIWQPNFSMVKEID 173 +++H ++ V ++ S D ++ + AD + + + Sbjct: 135 APVVQVESHQASKVHPRQVSGHVHSVVSSPDGQYLFAPDLGADKVFVYRYAPEQAERPLQ 194 Query: 174 AAHTESI--------RDMAFSSNDSK-FVTCSDDNILKIWNFSNGKQERVLSGHH----- 219 AA + R + FS++ ++T + ++ + R L H Sbjct: 195 AADPAFVPTPPGSGPRHLIFSADGRFAYLTLELSGQVMVFAHEGNGRLRQLQTHDLAPAG 254 Query: 220 --WDVKSCDWH--PEMGLIAS---ASKDNLVKL-WDPRSGNC--ISSILKFKHTVLKTRF 269 V + H + + + LV DP SG + + F Sbjct: 255 FQGKVGAGALHLSADGRFLGVLNRGDDNQLVTFAVDPASGQLRFVERRSVEGTEPREFAF 314 Query: 270 QPTKGNLLMAISKDKSCRVF 289 P +L+A RVF Sbjct: 315 SPGGRFVLVANQNSDQLRVF 334 >1RI6-A nrPDB Length = 343 Score = 36.6 bits (83), Expect = 0.020, Method: Composition-based stats. Identities = 21/252 (8%), Positives = 64/252 (25%), Gaps = 36/252 (14%) Query: 158 MIKIWQPNFSMVKEIDAAHTES--IRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVL 215 I +W N + ++ M S + ++ + + L Sbjct: 16 QIHVWNLNHEGALTLTQVVDVPGQVQPMVVSPDKRYL-YVGVRPEFRVLAYRIAPDDGAL 74 Query: 216 S-----GHHWDVKSCDWHPEMGLIASASKD-NLVKLWDPRSGNCI--SSILKFKHTVLKT 267 + + + + S + V + G + +++ Sbjct: 75 TFAAESALPGSLTHISTDHQGQFVFVGSYNAGNVSVTRLEDGLPVGVVDVVEGLDGCHSA 134 Query: 268 RFQPTKGNLLMAISKDKSCRVFDIRYSMKEL------MCVRDETDYMTLEWHPINESMFT 321 P L + K +F + + + + + +HP + + Sbjct: 135 NISPDNRTLWVPALKQDRICLFTVSDDGHLVAQDPAEVTTVEGAGPRHMVFHPNEQYAYC 194 Query: 322 LACYDGSLKHFDLLQNL-NEPILTIPY------AHDKCITSLSYNPVGHIFA-------- 366 + + S+ ++L N + + + + P G Sbjct: 195 VNELNSSVDVWELKDPHGNIECVQTLDMMPENFSDTRWAADIHITPDGRHLYACDRTASL 254 Query: 367 ----TAAKDRTI 374 + ++D ++ Sbjct: 255 ITVFSVSEDGSV 266 >4U1F-A nrPDB Length = 497 Score = 36.6 bits (83), Expect = 0.022, Method: Composition-based stats. Identities = 40/351 (11%), Positives = 102/351 (29%), Gaps = 67/351 (19%) Query: 82 SKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTM 141 ++ L ++ ++++P+G L G + W +F D V Sbjct: 51 NEEDSLVESRENWSTNYVRFSPKGTYLFSYHQQG-VTAWGGPNFDRLRRFYHPD--VRNS 107 Query: 142 KYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRD------------------- 182 S + ++++ + +I FS + + H I D Sbjct: 108 SVSPNEKYLVTFSTEPIIVEEDNEFSPFTKKNEGHQLCIWDIASGLLMATFPVIKSPYLK 167 Query: 183 ---MAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHH-WDVKSCDWHPEMGLI--AS 236 + +S ND D+++ + + + ++ + PE + Sbjct: 168 WPLVRWSYNDKYCARMVGDSLI-VHDATKNFMPLEAKALKPSGIRDFSFAPEGVKLQPFR 226 Query: 237 ASKDNLVKL--WDPRSGN--CISSILKFK-----HTVLKTRFQ------PTKGNLLM--- 278 + V L W P + N C ++I + TV + + L Sbjct: 227 NGDEPSVLLAYWTPETNNSACTATIAEVPRGRVLKTVNLVQVSNVTLHWQNQAEFLCFNV 286 Query: 279 ------AISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYD------ 326 ++ + ++ + + V + W P T++ ++ Sbjct: 287 ERHTKSGKTQFSNLQICRLTERDIPVEKVELKDSVFEFGWEPHGNRFVTISVHEVADMNY 346 Query: 327 ----GSLKHFDLLQNLNEPILT----IPYAHDKCITSLSYNPVGHIFATAA 369 +++ + ++ + ++S++P G A Sbjct: 347 AIPANTIRFYAPETKEKTDVIKRWSLVKEIPKTFANTVSWSPAGRFVVVGA 397 Score = 32.0 bits (71), Expect = 0.60, Method: Composition-based stats. Identities = 21/109 (19%), Positives = 47/109 (43%), Gaps = 6/109 (5%) Query: 120 WNASSFTFETLMQAHDSAVTT-MKYSHDSDWMISGDADGMIKIWQ-PNFSMVKEIDAAHT 177 WN+ ++L+++ ++ T +++S ++ S G + W PNF ++ H Sbjct: 46 WNSMFNEEDSLVESRENWSTNYVRFSPKGTYLFSYHQQG-VTAWGGPNFDRLRRFY--HP 102 Query: 178 ESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCD 226 + +R+ + S N+ VT S + I+ + + GH + Sbjct: 103 D-VRNSSVSPNEKYLVTFSTEPIIVEEDNEFSPFTKKNEGHQLCIWDIA 150 >4MHC-A nrPDB Length = 826 Score = 36.6 bits (83), Expect = 0.023, Method: Composition-based stats. Identities = 20/122 (16%), Positives = 39/122 (31%), Gaps = 17/122 (13%) Query: 239 KDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISK---------DKSCRVF 289 DN + LW+ + + I + +HT+LK + N ++ + D Sbjct: 109 SDNKLILWNINNSSEYHCIDEIEHTILKVKLVKPSPNTFVSSVENLLIVATLFDIYILTI 168 Query: 290 DIRYSMKELMCVRDETDYMTLEWHPIN-------ESMFTLACYDGSLKHFDLLQNLNEPI 342 EL ++ N +F DG + ++L N +E + Sbjct: 169 SFNDRTHELNIFNTGLKVNVTGFNVSNIISYERTGQIFFTGATDG-VNVWELQYNCSENL 227 Query: 343 LT 344 Sbjct: 228 FN 229 >2J04-A nrPDB Length = 588 Score = 36.3 bits (82), Expect = 0.033, Method: Composition-based stats. Identities = 33/287 (11%), Positives = 88/287 (30%), Gaps = 48/287 (16%) Query: 102 TPEGRRLVVATYSGEFSLW--NASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMI 159 +P + V + +G S++ N ++ +++ ++ G+ DG + Sbjct: 94 SPIDDWMAVLSNNGNVSVFKDNKMLTNLDSKGNLSSRTYHCFEWNPIESSIVVGNEDGEL 153 Query: 160 KIWQ--------PNFSMVKEI---DAAHTESIRDMAFSSNDSKFVTCSDDNIL---KIWN 205 + + P F I DA + + + + + V +N + + Sbjct: 154 QFFSIRKNSENTPEFYFESSIRLSDAGSKDWVTHIVW--YEDVLVAALSNNSVFSMTVSA 211 Query: 206 FSNGKQERVLSGHHWD-VKSCDWHPEMGLIASA-SKDNLVKLWDPRSGNCISSILKFKHT 263 S+ R++ + + ++ + + + D ++ + S Sbjct: 212 SSHQPVSRMIQNASRRKITDLKIV-DYKVVLTCPGYVHKI---DLKNYSISSLKTGSLEN 267 Query: 264 VLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLA 323 K + ++ +S S +V +++ + V + P E F Sbjct: 268 FHIIPLNHEKESTILLMSNKTSYKVL-----LEDELHVTADNII-----APYLEKKFKKW 317 Query: 324 CYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAK 370 ++ N ++ I +S +P G+ A Sbjct: 318 ST-----IWNEFNNYETTLV---------IHGISLSPDGYSIAIVYD 350 >4IMM-A nrPDB Length = 399 Score = 35.1 bits (79), Expect = 0.065, Method: Composition-based stats. Identities = 48/340 (14%), Positives = 93/340 (27%), Gaps = 46/340 (13%) Query: 92 VKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMI 151 ++ + +Q P ++ A+ SG S + S ++ A D + + Sbjct: 68 LRKDVIDLQIAPLADGMIAASRSGIVSGYMGESIAWQY--NAEDVITGGVGIDDQGSVAV 125 Query: 152 SGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQ 211 G G + + + + ++A SS ++ D ++ I N Sbjct: 126 IGTRSGKL--------IALDARTGAARWVVELASSSLAPALISG--DKVIVITNSGTIFG 175 Query: 212 ERVLSGHHWDVKSCDWHP------------EMGLIASASKDNLVKLWDPRSGNCISSIL- 258 + SG + + + D + D +G + + Sbjct: 176 LDINSGATVWQYATQVPNTSVRGMAKPLALDARTVLIGGADGRIHALDTMTGAPVWTRRV 235 Query: 259 ------KFKHTVLKTRFQPTKGNL-LMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLE 311 + PT + L A S FD+ + T +T Sbjct: 236 GLAMGSGEIDQLRDIDGTPTVVDHYLYAASYSGQLAGFDMTTGRTMFVSELSSTKKLTTL 295 Query: 312 WHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNP--VGHIFATAA 369 + DG + F+ + + HD L+ NP +G A Sbjct: 296 AD-----AVIGSSTDGDVVAFNRMTG-----EKLWENHDLKYRGLT-NPVTIGTYIAVGD 344 Query: 370 KDRTIRFWTRARPIDPNAYDDP-TYNNKKINGWFFGINND 408 D + I A N IN + + D Sbjct: 345 ADGVVHILNHQGQIISRANTKGALTNLTVINNRLYAQSAD 384 Score = 34.7 bits (78), Expect = 0.094, Method: Composition-based stats. Identities = 14/102 (13%), Positives = 39/102 (38%), Gaps = 15/102 (14%) Query: 108 LVVATYSGEFSLWNASSFTFE-----TLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIW 162 ++ ++ G+ +N + + + VT ++ GDADG++ I Sbjct: 299 VIGSSTDGDVVAFNRMTGEKLWENHDLKYRGLTNPVT------IGTYIAVGDADGVVHIL 352 Query: 163 QPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIW 204 ++ + ++ ++ +N + S D ++ +W Sbjct: 353 NHQGQIISRANT--KGALTNLTVINN--RLYAQSADGVVTVW 390 Score = 32.8 bits (73), Expect = 0.37, Method: Composition-based stats. Identities = 15/120 (12%), Positives = 39/120 (32%), Gaps = 17/120 (14%) Query: 50 LPNLVVEPETSYTIDIMPPNAYRGRDRVINLPS-----KFTHLSSNKVKHVIPAIQWTPE 104 + L + + D + ++ G N + + L + + + Sbjct: 283 VSELSSTKKLTTLADAVIGSSTDGDVVAFNRMTGEKLWENHDLKYRGLTNPVTI------ 336 Query: 105 GRRLVVATYSGEFSLWNASSFTFETL-MQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQ 163 G + V G + N + + +T + ++ + + ADG++ +WQ Sbjct: 337 GTYIAVGDADGVVHILNHQGQIISRANTKGALTNLTVI-----NNRLYAQSADGVVTVWQ 391 >5TXC-A nrPDB Length = 705 Score = 34.7 bits (78), Expect = 0.079, Method: Composition-based stats. Identities = 21/160 (13%), Positives = 49/160 (30%), Gaps = 19/160 (11%) Query: 82 SKFTHLSSNKVKHVIPAIQWTPEGRRLV--VATYSGEFSLWNASSFTFETLMQAHDSAVT 139 + + + P + +P+GR + V +L F +++A D A Sbjct: 44 VRLADIGTMSASETTPLLSLSPDGRYVAFQVRQADPVTNL-----NVFRMVVKATDGATD 98 Query: 140 TMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDD- 198 + +++ W + +S + + D Sbjct: 99 AIDVDVGGEYL----------FWTIPSWGYARNAPSGANLTIQPRWSPSGTHLAYLRQDQ 148 Query: 199 NILKIWNFS-NGKQERVLSGHHWDVKSCDWHPEMGLIASA 237 +++W S G+ + +D++ W + LI S Sbjct: 149 GRVRVWRASVKGEGASPVIEDAYDIEDVQWLDDNTLIYSG 188 Score = 28.9 bits (63), Expect = 4.3, Method: Composition-based stats. Identities = 9/80 (11%), Positives = 20/80 (25%), Gaps = 2/80 (2%) Query: 289 FDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYA 348 + I + W P + L G ++ + I A Sbjct: 111 WTIPSWGYARNAPSGANLTIQPRWSPSGTHLAYLRQDQGRVRVWRASVKGEGASPVIEDA 170 Query: 349 HDKCITSLSYNPVGHIFATA 368 +D I + + + + Sbjct: 171 YD--IEDVQWLDDNTLIYSG 188 >5CWW-B nrPDB Length = 595 Score = 33.9 bits (76), Expect = 0.13, Method: Composition-based stats. Identities = 15/108 (13%), Positives = 35/108 (32%), Gaps = 21/108 (19%) Query: 87 LSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLW---NASSFTFE--------------T 129 + V I + +P L V S + ++S + T Sbjct: 108 IIKTPVADDIRQLVMSPNQDFLAV-LTSHTVHICILPDSSHLHIQDTTPFKPKFWTLGPT 166 Query: 130 LMQAHDSAVTTMKYSH---DSDWMISGDADGMIKIWQPNFSMVKEIDA 174 SAV + + + +++ D ++++W+ + + DA Sbjct: 167 THVTSRSAVVSAVWHPLGVNGHALVTVTEDAIVRVWELSTADRWTFDA 214 Score = 31.6 bits (70), Expect = 0.68, Method: Composition-based stats. Identities = 15/94 (15%), Positives = 33/94 (35%), Gaps = 19/94 (20%) Query: 178 ESIRDMAFSSNDSKF--VTCSDDNILKIWNFSNGKQE--------------RVLSGHHWD 221 + IR + S N +T +I + + S+ + Sbjct: 115 DDIRQLVMSPNQDFLAVLTSHTVHICILPDSSHLHIQDTTPFKPKFWTLGPTTHVTSRSA 174 Query: 222 VKSCDWHP---EMGLIASASKDNLVKLWDPRSGN 252 V S WHP + + ++D +V++W+ + + Sbjct: 175 VVSAVWHPLGVNGHALVTVTEDAIVRVWELSTAD 208 Score = 30.5 bits (67), Expect = 1.5, Method: Composition-based stats. Identities = 8/35 (22%), Positives = 14/35 (40%), Gaps = 3/35 (8%) Query: 351 KCITSLSYNP---VGHIFATAAKDRTIRFWTRARP 382 + S ++P GH T +D +R W + Sbjct: 173 SAVVSAVWHPLGVNGHALVTVTEDAIVRVWELSTA 207 Score = 28.6 bits (62), Expect = 5.6, Method: Composition-based stats. Identities = 6/46 (13%), Positives = 17/46 (36%), Gaps = 2/46 (4%) Query: 293 YSMKELMCVRDETDYMTLEWHPIN--ESMFTLACYDGSLKHFDLLQ 336 +++ V + ++ WHP+ D ++ ++L Sbjct: 161 WTLGPTTHVTSRSAVVSAVWHPLGVNGHALVTVTEDAIVRVWELST 206 >6GC1-A nrPDB Length = 579 Score = 33.9 bits (76), Expect = 0.16, Method: Composition-based stats. Identities = 37/290 (12%), Positives = 94/290 (32%), Gaps = 51/290 (17%) Query: 47 RHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGR 106 H + + +E E + + +G D+ + +SS + G Sbjct: 305 NHLIRKIDLEAEK---VSTVAGIGIQGTDKEGGAKGEQQPISSPWDVVFGTSGSEVQRGD 361 Query: 107 RLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNF 166 L +A +G +W + + + + T ++++ + N Sbjct: 362 ILWIA-MAGTHQIWALLLDSGKLPKKNELTKGTCLRFAGSGNEE------------NRNN 408 Query: 167 SMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVK--- 223 + + A + + FV S+ + ++ + +G + ++ G + Sbjct: 409 AYPHKAGFAQPSGLSLASEDPWSCLFVADSESSTVRTVSLKDGAVKHLVGGERDPMNLFA 468 Query: 224 -----------------SCDWHPEMGLIASA-SKDNLVKLWDPRSGNCIS-SILKFKHTV 264 W + L+ A S ++ +K+ DP++ NC + + + V Sbjct: 469 FGDVDGVGINAKLQHPLGVTWDKKRNLLYVADSYNHKIKVVDPKTKNCTTLAGTGDTNNV 528 Query: 265 LKTRFQPTKGN-------------LLMAISKDKSCRVFDIRYSMKELMCV 301 + F + N L +A + + +V D+ M ++ + Sbjct: 529 TSSSFTESTFNEPGGLCIGENGELLYVADTNNHQIKVMDLETKMVSVLPI 578 >3AZQ-A nrPDB Length = 662 Score = 32.8 bits (73), Expect = 0.31, Method: Composition-based stats. Identities = 32/248 (12%), Positives = 63/248 (25%), Gaps = 34/248 (13%) Query: 135 DSAVTTMKYSHDS-------DWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSS 187 V M ++ + DG + S V+E+ + S Sbjct: 141 RGEVWCMAEEFTGEGPSDVRRFLAAVPLDGSAA---ADRSAVRELSDDAHRFVTGPRLSP 197 Query: 188 NDSKFVTCSDDNILKIW------------NFSNGKQERVLSGHHWDVKSCDWHPEMGLIA 235 + + V + D+ W + +L G + +W P+ LI Sbjct: 198 DGRQAVWLAWDHPRMPWEGTELKTARVTEDGRFADTRTLLGGPEEAIAQAEWAPDGSLIV 257 Query: 236 SASKDNL----VKLWDPRSGNCIS---SILKFKHTVLKTR---FQPTKGNLLMAISKDKS 285 + D + DP +G +F + F P L+ + + Sbjct: 258 A--TDRTGWWNLHRVDPATGAATQLCRREEEFAGPLWTPGMRWFAPLANGLIAVVHGKGA 315 Query: 286 CRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTI 345 + + EL+ +A + L + TI Sbjct: 316 AVLGILDPESGELVDAAGPWTEWAATLTVSGTRAVGVAASPRTAYEVVELDTVTGRARTI 375 Query: 346 PYAHDKCI 353 H + Sbjct: 376 GARHTDPV 383 >2FAW-A nrPDB Length = 266 Score = 32.4 bits (72), Expect = 0.39, Method: Composition-based stats. Identities = 23/156 (14%), Positives = 56/156 (35%), Gaps = 27/156 (17%) Query: 245 LWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDI------------- 291 ++D R+ + I + T G +L D + +++I Sbjct: 90 IYDRRTLSNIKNFTHQMKDGWGLA---TDGKIL--YGSDGTSILYEIDPHTFKLIKKHNV 144 Query: 292 RYSMKELMCVRDETDYMTLEWHPINESMFT--LACYDGSLKHFDLLQNLNEPILTIPYAH 349 +Y+ ++ + + W I ++ ++ DG+L + LL NL + ++ + Sbjct: 145 KYNGHRVIRLNELEYINGEVWANIWQTDCIARISAKDGTLLGWILLPNLRKKLIDEGFRD 204 Query: 350 DKCITSLSYNPVGH-IFATAAKDRTIRFWTRARPID 384 + ++++ IF T + W + I Sbjct: 205 IDVLNGIAWDQENKRIFVTG------KLWPKLFEIK 234 >1Z68-A nrPDB Length = 719 Score = 32.0 bits (71), Expect = 0.49, Method: Composition-based stats. Identities = 21/127 (16%), Positives = 38/127 (29%), Gaps = 14/127 (11%) Query: 269 FQPT--KGNLLMAISKDKSCRVFDIRYSMKELMCVRDE-TDYMTLEWHPINESMFTLACY 325 F P G + S D + +++I + + + F Sbjct: 19 FFPNWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLES 78 Query: 326 DGSLKHFDLLQNLNEPILTIPYAH-------DKCITSLSYNPVGHIFATAAKDRTIRFWT 378 D S K + I + + I L ++PVG A ++ + Sbjct: 79 DYS-KLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNN---IYL 134 Query: 379 RARPIDP 385 + RP DP Sbjct: 135 KQRPGDP 141 >5UE8-A nrPDB Length = 961 Score = 31.3 bits (69), Expect = 1.0, Method: Composition-based stats. Identities = 13/58 (22%), Positives = 23/58 (39%), Gaps = 5/58 (8%) Query: 194 TCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDN-LVKLWDPRS 250 T S D + + K+ + + G+ V ++H E S D V++WD Sbjct: 179 TGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHN----SSDRIKVRVWDEDD 232 >2GBG-A nrPDB Length = 730 Score = 30.5 bits (67), Expect = 1.5, Method: Composition-based stats. Identities = 19/167 (11%), Positives = 43/167 (25%), Gaps = 14/167 (8%) Query: 224 SCDWHP---EMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAI 280 S W ++A D +W+ + ++ T RF+P + + Sbjct: 273 SLQWLRRIQNYSVMAICDYDKTTLVWNCPT---TQEHIETSATGWCGRFRPAEPHFTSDG 329 Query: 281 SKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNE 340 S V D +D + S + + E Sbjct: 330 SSFYKI-VSDKDGYKHICQFQKDRKPEQVCTFITKGAWEVISIEALTSDYLYYISNEYKE 388 Query: 341 -------PILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFWTRA 380 + + +K S NP + + + + +++ Sbjct: 389 MPGGRNLYKIQLTDHTNKKCLSCDLNPERCQYYSVSLSKEAKYYQLG 435 >2VR2-A nrPDB Length = 541 Score = 30.5 bits (67), Expect = 1.5, Method: Composition-based stats. Identities = 13/49 (26%), Positives = 20/49 (40%), Gaps = 5/49 (10%) Query: 229 PEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLL 277 P G IA S D + +WDP+ IS+ + F +G + Sbjct: 412 PRKGRIAVGS-DADIVIWDPKGTRTISAKTHHQ----AVNFNIFEGMVC 455 >1XFD-A nrPDB Length = 723 Score = 30.1 bits (66), Expect = 1.9, Method: Composition-based stats. Identities = 8/46 (17%), Positives = 18/46 (39%), Gaps = 7/46 (15%) Query: 113 YSGEFSLWNASSFTFETLMQAHDSAVTTMK-----YSHDSDWMISG 153 G LWN + T L++ + +++ S D ++ + Sbjct: 35 QKGTVRLWNVETNTSTVLIEG--KKIESLRAIRYEISPDREYALFS 78 >6FTI-5 nrPDB Length = 705 Score = 30.1 bits (66), Expect = 2.0, Method: Composition-based stats. Identities = 21/137 (15%), Positives = 41/137 (29%), Gaps = 13/137 (9%) Query: 73 GRDRVINLPSKFTHLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQ 132 G +V++ K +S K P + + + F Sbjct: 421 GVSQVLSTYMKNLDISRPDKKSKKQQDSTYPIKNEVASG------MILVMAFFLITYTF- 473 Query: 133 AHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKF 192 H + VT+ YS S + + DG I+ + E + M++ + Sbjct: 474 -HSTWVTSEAYSSPSIVLSARGGDGSRIIFDDFREAYYWLRHNTPEDAKVMSWWDYGYQI 532 Query: 193 VTCSDDNILKI----WN 205 T + + + WN Sbjct: 533 -TAMANRTILVDNNTWN 548 >3NCG-A nrPDB Length = 486 Score = 30.1 bits (66), Expect = 2.0, Method: Composition-based stats. Identities = 23/110 (20%), Positives = 41/110 (37%), Gaps = 13/110 (11%) Query: 190 SKFVTCSD--DNILKIWNFSNGKQERVLSG--------HHWDVKSCDWHPEMGLIASASK 239 + T + D I+K FS R++ H ++ D PE L+ S K Sbjct: 100 GELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEK 159 Query: 240 DNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVF 289 D +K+ D C K K + + + ++ + D+ C V+ Sbjct: 160 DCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPE---VLRGTYDEKCDVW 206 >3DFA-A nrPDB Length = 286 Score = 30.1 bits (66), Expect = 2.0, Method: Composition-based stats. Identities = 23/110 (20%), Positives = 41/110 (37%), Gaps = 13/110 (11%) Query: 190 SKFVTCSD--DNILKIWNFSNGKQERVLSG--------HHWDVKSCDWHPEMGLIASASK 239 + T + D I+K FS R++ H ++ D PE L+ S K Sbjct: 100 GELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHNIVHRDLKPENILLESKEK 159 Query: 240 DNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVF 289 D +K+ D C K K + + + ++ + D+ C V+ Sbjct: 160 DCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPE---VLRGTYDEKCDVW 206 >3R3L-A nrPDB Length = 582 Score = 29.7 bits (65), Expect = 2.9, Method: Composition-based stats. Identities = 6/31 (19%), Positives = 14/31 (45%) Query: 187 SNDSKFVTCSDDNILKIWNFSNGKQERVLSG 217 +N S+ D ++++W+ N + G Sbjct: 147 TNGSQGSQAGRDGVVRVWDVKNAELLNNQFG 177 >3FE4-A nrPDB Length = 278 Score = 29.7 bits (65), Expect = 3.1, Method: Composition-based stats. Identities = 11/43 (25%), Positives = 19/43 (44%), Gaps = 3/43 (6%) Query: 24 KKYVTQRRSVDVSSPYINLYYNRRHGLPNLVVE---PETSYTI 63 + + + +D + I+ Y R L + VVE P YT+ Sbjct: 224 QVWKLENSLLDHRNKTIHNDYRRTQPLNHRVVESNFPNQEYTL 266 >1FLG-A nrPDB Length = 582 Score = 29.3 bits (64), Expect = 3.7, Method: Composition-based stats. Identities = 10/93 (10%), Positives = 27/93 (29%), Gaps = 4/93 (4%) Query: 115 GEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDA 174 G + S + H + + + + +G DG K + Sbjct: 466 GSLRAMDPVSGKVVWEHKEHL-PLWAGVLATAGNLVFTGTGDGYFKAFDAKSGKELWKFQ 524 Query: 175 AHTESIR-DMAFSSNDSKF--VTCSDDNILKIW 204 + + + + + ++ VT + +W Sbjct: 525 TGSGIVSPPITWEQDGEQYLGVTVGYGGAVPLW 557 >3MWP-A nrPDB Length = 577 Score = 28.9 bits (63), Expect = 4.1, Method: Composition-based stats. Identities = 5/31 (16%), Positives = 13/31 (41%) Query: 187 SNDSKFVTCSDDNILKIWNFSNGKQERVLSG 217 S ++ D ++++W+ N + G Sbjct: 155 SGGNQGARAGRDGVVRVWDVKNAELLNNQFG 185 >6NYT-A nrPDB Length = 148 Score = 28.9 bits (63), Expect = 4.4, Method: Composition-based stats. Identities = 13/58 (22%), Positives = 23/58 (39%), Gaps = 5/58 (8%) Query: 194 TCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDN-LVKLWDPRS 250 T S D + + K+ + + G+ V ++H E S D V++WD Sbjct: 35 TGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHN----SSDRIKVRVWDEDD 88 >2FTW-A nrPDB Length = 521 Score = 28.9 bits (63), Expect = 4.8, Method: Composition-based stats. Identities = 13/71 (18%), Positives = 25/71 (35%), Gaps = 5/71 (7%) Query: 238 SKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKE 297 D + +WDP IS F +G + + + +I +S + Sbjct: 397 GCDGDIVIWDPNQSKTISKDTHHH----AVDFNIFEG-IKVTGIAVTTIVAGNIVWSDNK 451 Query: 298 LMCVRDETDYM 308 L CV+ ++ Sbjct: 452 LSCVKGSGRFV 462 >1SVV-A nrPDB Length = 359 Score = 28.9 bits (63), Expect = 4.8, Method: Composition-based stats. Identities = 18/135 (13%), Positives = 34/135 (25%), Gaps = 10/135 (7%) Query: 265 LKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWH---------PI 315 T +P + + S ++ D+ D + P Sbjct: 7 TATAAKPKPYSFVNDYSVGMHPKILDLMARDNMTQHAGYGQDSHCAKAARLIGELLERPD 66 Query: 316 NESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATA-AKDRTI 374 + F +L L E ++ H + + GH TA D + Sbjct: 67 ADVHFISGGTQTNLIACSLALRPWEAVIATQLGHISTHETGAIEATGHKVVTAPCPDGKL 126 Query: 375 RFWTRARPIDPNAYD 389 R + N + Sbjct: 127 RVADIESALHENRSE 141 >1OA3-A nrPDB Length = 218 Score = 28.2 bits (61), Expect = 7.9, Method: Composition-based stats. Identities = 16/106 (15%), Positives = 36/106 (33%), Gaps = 9/106 (8%) Query: 226 DWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKS 285 WH + S ++ + +S + + K TV PT + + S ++ Sbjct: 43 SWHADWQW--SGGQN------NVKSYQNVQINIPQKRTVNSIGSMPTTASWSYSGSDIRA 94 Query: 286 CRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKH 331 +D+ ++ V DY + W + + G++ Sbjct: 95 NVAYDL-FTAANPNHVTYSGDYELMIWLGKYGDIGPIGSSQGTVNV 139 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.308 0.128 0.351 Lambda K H 0.267 0.0398 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,031,199 Number of Sequences: 36641 Number of extensions: 689674 Number of successful extensions: 6872 Number of sequences better than 10.0: 180 Number of HSP's better than 10.0 without gapping: 249 Number of HSP's successfully gapped in prelim test: 71 Number of HSP's that attempted gapping in prelim test: 1811 Number of HSP's gapped (non-prelim): 1412 length of query: 465 length of database: 10,336,785 effective HSP length: 101 effective length of query: 364 effective length of database: 6,636,044 effective search space: 2415520016 effective search space used: 2415520016 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 61 (28.1 bits)