BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P42262 (883 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4U1Y-A nrPDB 1615 0.0 5IDF-B nrPDB 1334 0.0 6QKC-A nrPDB 1274 0.0 5KUF-A nrPDB 632 0.0 5KUH-A nrPDB 298 5e-81 5O9A-A nrPDB 297 1e-80 3FAT-A nrPDB 280 2e-75 3DP4-A nrPDB 272 4e-73 5FXI-A nrPDB 241 8e-64 5UOW-A nrPDB 235 8e-62 5UN1-G nrPDB 229 6e-60 5UN1-B nrPDB 188 7e-48 6IRA-D nrPDB 186 4e-47 5IPR-B nrPDB 180 3e-45 4PE5-B nrPDB 175 6e-44 5DT6-A nrPDB 173 3e-43 5UP2-B nrPDB 172 5e-43 1YAE-A nrPDB 170 3e-42 5EHM-A nrPDB 166 5e-41 5L2E-A nrPDB 165 9e-41 5IKB-A nrPDB 152 5e-37 2XXT-A nrPDB 147 1e-35 4MF3-A nrPDB 147 2e-35 4IGR-A nrPDB 146 4e-35 4WXJ-A nrPDB 100 3e-21 5CC2-A nrPDB 93 5e-19 5I2K-B nrPDB 89 9e-18 3OEK-A nrPDB 84 3e-16 2RCB-A nrPDB 81 2e-15 5H8N-A nrPDB 81 2e-15 2RC9-A nrPDB 78 2e-14 4YKP-A nrPDB 69 7e-12 5TUJ-C nrPDB 59 7e-09 4ZDM-A nrPDB 53 5e-07 4PSH-A nrPDB 52 2e-06 4ZV2-A nrPDB 50 3e-06 3K4U-A nrPDB 49 8e-06 4F3S-A nrPDB 49 1e-05 5JOS-A nrPDB 47 4e-05 4F3P-A nrPDB 47 4e-05 4IO3-A nrPDB 45 1e-04 4H5F-A nrPDB 44 3e-04 1GGG-A nrPDB 43 6e-04 4G4P-A nrPDB 42 0.001 4KQP-A nrPDB 42 0.001 6FXG-A nrPDB 41 0.002 2Q2A-A nrPDB 41 0.002 4KPT-A nrPDB 40 0.003 4ZEF-A nrPDB 40 0.003 4MS4-A nrPDB 40 0.006 4YMX-A nrPDB 39 0.007 2IEE-A nrPDB 39 0.010 4I62-A nrPDB 39 0.010 2PYY-A nrPDB 38 0.015 5OTA-A nrPDB 37 0.032 3HDI-A nrPDB 36 0.065 4OEN-A nrPDB 35 0.14 5ORE-A nrPDB 35 0.18 5EYF-A nrPDB 34 0.24 3I6V-A nrPDB 34 0.24 3VV5-A nrPDB 34 0.32 3TQL-A nrPDB 33 0.38 2HYI-C nrPDB 33 0.54 5HPQ-A nrPDB 33 0.57 5LOM-A nrPDB 32 0.88 4YND-A nrPDB 32 0.98 3EIQ-A nrPDB 32 1.3 2Y7I-A nrPDB 32 1.6 5VXG-A nrPDB 30 3.5 >4U1Y-A nrPDB Length = 819 Score = 1615 bits (4181), Expect = 0.0, Method: Compositional matrix adjust. Identities = 787/823 (95%), Positives = 792/823 (96%), Gaps = 9/823 (1%) Query: 25 NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRG 84 NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRG Sbjct: 1 NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRG 60 Query: 85 VYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQ 144 VYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQ Sbjct: 61 VYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQ 120 Query: 145 WDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQDLELKKE 204 WDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDE YRSLFQDLELKKE Sbjct: 121 WDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYRSLFQDLELKKE 180 Query: 205 RRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVD 264 RRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGA VSGFQIVD Sbjct: 181 RRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVD 240 Query: 265 YDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRR 324 YDDSLVSKFIERWSTLEEKEYPGAHT TIKYTSALTYDAVQVMTEAFRNLRKQRIEISRR Sbjct: 241 YDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRR 300 Query: 325 GNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPR 384 GNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPR Sbjct: 301 GNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPR 360 Query: 385 KIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEG 444 KIGYWSEVDKMVVTLTE +DTSGLE KTVVVTTILESPYVMMKKNHEMLEGNERYEG Sbjct: 361 KIGYWSEVDKMVVTLTE----DDTSGLEQKTVVVTTILESPYVMMKKNHEMLEGNERYEG 416 Query: 445 YCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITL 504 YCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITL Sbjct: 417 YCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITL 476 Query: 505 VREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLV 564 VREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWM IVFAYI VSVVLFLV Sbjct: 477 VREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMAIVFAYILVSVVLFLV 536 Query: 565 SRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGG 624 SRFSPYEWHTEEFEDG ESTNEFGIFNS WF+L F QQG DISPRSLS RIV G Sbjct: 537 SRFSPYEWHTEEFEDGE-----ESTNEFGIFNSFWFALKLFFQQGADISPRSLSARIVAG 591 Query: 625 VWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSK 684 VWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSK Sbjct: 592 VWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSK 651 Query: 685 IAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKV 744 IAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKV Sbjct: 652 IAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKV 711 Query: 745 GGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEK 804 GGNLDSKGYGIATPKGSSL VNLAVLKL+EQG+LDKLKNKWWYDKGECG+ SKEK Sbjct: 712 GGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEK 771 Query: 805 TSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMK 847 TSALSLSNVAGVFYILVGGLGLAMLVALIEF YKSRAEAKRMK Sbjct: 772 TSALSLSNVAGVFYILVGGLGLAMLVALIEFAYKSRAEAKRMK 814 >5IDF-B nrPDB Length = 874 Score = 1334 bits (3452), Expect = 0.0, Method: Compositional matrix adjust. Identities = 628/867 (72%), Positives = 749/867 (86%), Gaps = 12/867 (1%) Query: 25 NSIQIGGLFPRGADQEYSAFRVGMVQFSTSE------FRLTPHIDNLEVANSFAVTNAFC 78 N+I IGGLF R QE+SAFR + ++T++ F L H+D+L+ +NSF+VTNAFC Sbjct: 12 NTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFC 71 Query: 79 SQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLS 138 SQFSRGVYAIFGFYD+ S+NT+TSFCG LH SF+TPSFPTD FVIQMRP LKGA+LS Sbjct: 72 SQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADVQFVIQMRPALKGAILS 131 Query: 139 LIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQD 198 L+ YY+W+KF YLYD++RG S LQA++++A + WQVTA +VGNI K + +R + ++ Sbjct: 132 LLSYYKWEKFVYLYDTERGFSVLQAIMEAAVQNNWQVTARSVGNI---KDVQEFRRIIEE 188 Query: 199 LELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVS 258 ++ ++E+R ++DCE +++N I++QV+ +GKH +GYHY++ANLGFTD L ++ GGAN++ Sbjct: 189 MDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANIT 248 Query: 259 GFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQR 318 GFQIV+ ++ +V +FI+RW L+E E+P A +KYTSALT+DA+ V+ EAFR LR+QR Sbjct: 249 GFQIVNNENPMVQQFIQRWVRLDECEFPEAKNAPLKYTSALTHDAILVIAEAFRYLRRQR 308 Query: 319 IEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMEL 378 +++SRRG+AGDCLANPAVPW QG++IERALK VQV+G++GNI+FD G+R NYTI++ E+ Sbjct: 309 VDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEM 368 Query: 379 KTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEG 438 K +G RK GYW+E ++ V ++ ND+S EN+T+VVTTILESPYVM KKNHE LEG Sbjct: 369 KVSGSRKAGYWNEYERFV-PFSDQQISNDSSSSENRTIVVTTILESPYVMYKKNHEQLEG 427 Query: 439 NERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIA 498 NERYEGYCVDLA EIAKH G KYKL+IVGDGKYGARD +TKIWNGMVGELVYG+ADIA+A Sbjct: 428 NERYEGYCVDLAYEIAKHVGIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVA 487 Query: 499 PLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVS 558 PLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVS Sbjct: 488 PLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVS 547 Query: 559 VVLFLVSRFSPYEWHTEEF-EDGRETQSS-ESTNEFGIFNSLWFSLGAFMQQGCDISPRS 616 VVLFLVSRFSPYEWH E+ E+ R+ QS + NEFGIFNSLWFSLGAFMQQGCDISPRS Sbjct: 548 VVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRS 607 Query: 617 LSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGST 676 LSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL+KQTEIAYGTLDSGST Sbjct: 608 LSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGST 667 Query: 677 KEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR 736 KEFFRRSKIAV++KMW+YM+SAEPSVF +TTA+GVARVRKSKGK+A+LLESTMNEYIEQR Sbjct: 668 KEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQR 727 Query: 737 KPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGS 796 KPCDTMKVGGNLDSKGYG+ATPKGS+L VNLAVLKL+EQG+LDKLKNKWWYDKGECG+ Sbjct: 728 KPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGECGA 787 Query: 797 GGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKNAQNIN 856 SK+KTSALSLSNVAGVFYILVGGLGLAM+VALIEFCYKSRAE+KRMK+ KN QN Sbjct: 788 KDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTKNTQNFK 847 Query: 857 PSSSQNSQNFATYKEGYNVYGIESVKI 883 P+ + N+QN+ATY+EGYNVYG ESVKI Sbjct: 848 PAPATNTQNYATYREGYNVYGTESVKI 874 >6QKC-A nrPDB Length = 915 Score = 1274 bits (3297), Expect = 0.0, Method: Compositional matrix adjust. Identities = 596/823 (72%), Positives = 712/823 (86%), Gaps = 5/823 (0%) Query: 25 NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRG 84 N+IQIGGLFP QE++AFR + Q T +L P ID + +++SF +T FCSQFS+G Sbjct: 31 NNIQIGGLFPNQQSQEHAAFRFALSQL-TEPPKLLPQIDIVNISDSFEMTYRFCSQFSKG 89 Query: 85 VYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQ 144 VYAIFGFY++++VN +TSFCG LHV FITPSFP D ++ FV+Q+RP+L+ AL+S+I++Y+ Sbjct: 90 VYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQFVLQLRPELQEALISIIDHYK 149 Query: 145 WDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQDLELKKE 204 W F Y+YD+DRGLS LQ VLD+AAEK WQVTA+N+ +E YR LFQDLE KKE Sbjct: 150 WQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTTT----EEGYRMLFQDLEKKKE 205 Query: 205 RRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVD 264 R V++DCE +++N I+ Q++ + K+ GYHYI+ANLGF D DL K + GANV+GFQ+V+ Sbjct: 206 RLVVVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVN 265 Query: 265 YDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRR 324 Y D++ ++ +++W T + +++ KYTSALTYD V+VM EAF++LR+QRI+ISRR Sbjct: 266 YTDTIPARIMQQWRTSDSRDHTRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRR 325 Query: 325 GNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPR 384 GNAGDCLANPAVPWGQG++I+RAL+QV+ EGL+GN++F++ G+R NYT++++E+K +G R Sbjct: 326 GNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIR 385 Query: 385 KIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEG 444 KIGYW+E DK V T+ +G D S ++N+T +VTTILE PYVM+KKN EGN+RYEG Sbjct: 386 KIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEG 445 Query: 445 YCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITL 504 YCV+LAAEIAKH G+ Y+L IV DGKYGARD DTK WNGMVGELVYG+AD+A+APLTITL Sbjct: 446 YCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITL 505 Query: 505 VREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLV 564 VREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLV Sbjct: 506 VREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLV 565 Query: 565 SRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGG 624 SRFSPYEWH+EEFE+GR+ +S+ +NEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGG Sbjct: 566 SRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGG 625 Query: 625 VWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSK 684 VWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL+KQTEIAYGTL++GSTKEFFRRSK Sbjct: 626 VWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSK 685 Query: 685 IAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKV 744 IAVF+KMWTYM+SAEPSVFVRTT EG+ RVRKSKGKYAYLLESTMNEYIEQRKPCDTMKV Sbjct: 686 IAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKV 745 Query: 745 GGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEK 804 GGNLDSKGYGIATPKGS+LR VNLAVLKL+EQG+LDKLK+KWWYDKGECGS SK+K Sbjct: 746 GGNLDSKGYGIATPKGSALRGPVNLAVLKLSEQGVLDKLKSKWWYDKGECGSKDSGSKDK 805 Query: 805 TSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMK 847 TSALSLSNVAGVFYIL+GGLGLAMLVALIEFCYKSR+E+KRMK Sbjct: 806 TSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMK 848 >5KUF-A nrPDB Length = 877 Score = 632 bits (1631), Expect = 0.0, Method: Compositional matrix adjust. Identities = 346/847 (40%), Positives = 510/847 (60%), Gaps = 46/847 (5%) Query: 23 SSNSIQIGGLF------PRGADQEYSAFRVGMVQFSTSEF---RLTPHIDNLEVANSFAV 73 +++ ++ GG+F P GA++ F V + + + LT + + +SF Sbjct: 1 TTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEA 60 Query: 74 TNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFP---TDGTHPFVIQMRP 130 + C Q S GV AIFG S N + S C L V I + +D F + + P Sbjct: 61 SKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYP 120 Query: 131 D---LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDK 187 D L A+L L+++++W +YD GL LQ ++ + + + + + + D Sbjct: 121 DFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLR---LKIRQLPADT 177 Query: 188 KDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDL 247 KD + L ++++ KE VI DC + I+ Q + +G + YHYI L D+ Sbjct: 178 KDA--KPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDV 235 Query: 248 LKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYP-----GAHTTTIKYTSALTYD 302 ++ G N++GF+I++ +++ VS IE+WS +E + P G + +AL YD Sbjct: 236 EPYRYSGVNMTGFRILNTENTQVSSIIEKWS-MERLQAPPKPDSGLLDGFMTTDAALMYD 294 Query: 303 AVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKF 362 AV V++ A + + + ++ C N PW G +K+ EGL+G I F Sbjct: 295 AVHVVSVAVQQFPQMTV------SSLQC--NRHKPWRFGTRFMSLIKEAHWEGLTGRITF 346 Query: 363 DQ-NGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTEL-PSGNDTSGLENKTVVVTT 420 ++ NG R ++ ++++ LK G KIG W + +T ++ N T L N++++VTT Sbjct: 347 NKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTT 406 Query: 421 ILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKI 480 ILE PYV+ KK+ + L GN+R+EGYC+DL E++ GF Y++ +V DGKYGA+D Sbjct: 407 ILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQ 466 Query: 481 WNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLD 540 WNGMV EL+ KAD+A+APLTIT VRE+VIDFSKPFM+LGISI+ +KP + PGVFSFL+ Sbjct: 467 WNGMVRELIDHKADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLN 526 Query: 541 PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWF 600 PL+ +IWM ++ AY+GVSVVLF+++RFSPYEW+ S N F + NS WF Sbjct: 527 PLSPDIWMYVLLAYLGVSVVLFVIARFSPYEWYNPH---PCNPDSDVVENNFTLLNSFWF 583 Query: 601 SLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL 660 +GA MQQG ++ P++LS RIVGG+WWFFTLIIISSYTANLAAFLTVERM SPI+SA+DL Sbjct: 584 GVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDL 643 Query: 661 SKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGK 720 +KQT+I YG ++ GST FF++SKI+ +DKMW +M S SV V+++ EG+ RV S Sbjct: 644 AKQTKIEYGAVEDGSTMTFFKKSKISTYDKMWAFMSSRRQSVLVKSSEEGIQRVLTS--D 701 Query: 721 YAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLL 780 YA L+EST E++ QR C+ ++GG +DSKGYG+ TP GS R+ + +A+L+L E+G L Sbjct: 702 YALLMESTTIEFVTQRN-CNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKL 760 Query: 781 DKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR 840 +K KWW G C +SKE SAL + N+ G+F +L GL L++ VA+ EF YKS+ Sbjct: 761 HMMKEKWWRGNG-CPE--EESKE-ASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSK 816 Query: 841 AEAKRMK 847 A+ K Sbjct: 817 KNAQLEK 823 >5KUH-A nrPDB Length = 757 Score = 298 bits (764), Expect = 5e-81, Method: Compositional matrix adjust. Identities = 179/527 (33%), Positives = 285/527 (54%), Gaps = 36/527 (6%) Query: 23 SSNSIQIGGLF------PRGADQEYSAFRVGMVQFSTSEF---RLTPHIDNLEVANSFAV 73 +++ ++ GG+F P GA++ F V + + + LT + + +SF Sbjct: 1 TTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEA 60 Query: 74 TNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFP---TDGTHPFVIQMRP 130 + C Q S GV AIFG S N + S C L V I + +D F + + P Sbjct: 61 SKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYP 120 Query: 131 D---LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDK 187 D L A+L L+++++W +YD GL LQ ++ + + + + + + D Sbjct: 121 DFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLR---LKIRQLPADT 177 Query: 188 KDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDL 247 KD + L ++++ KE VI DC + I+ Q + +G + YHYI L D+ Sbjct: 178 KDA--KPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDV 235 Query: 248 LKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYP-----GAHTTTIKYTSALTYD 302 ++ G N++GF+I++ +++ VS IE+WS +E + P G + +AL YD Sbjct: 236 EPYRYSGVNMTGFRILNTENTQVSSIIEKWS-MERLQAPPKPDSGLLDGFMTTDAALMYD 294 Query: 303 AVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKF 362 AV V++ A + + + ++ C N PW G +K+ EGL+G I F Sbjct: 295 AVHVVSVAVQQFPQMTV------SSLQC--NRHKPWRFGTRFMSLIKEAHWEGLTGRITF 346 Query: 363 DQ-NGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTEL-PSGNDTSGLENKTVVVTT 420 ++ NG R ++ ++++ LK G KIG W + +T ++ N T L N++++VTT Sbjct: 347 NKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTT 406 Query: 421 ILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKI 480 ILE PYV+ KK+ + L GN+R+EGYC+DL E++ GF Y++ +V DGKYGA+D Sbjct: 407 ILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQ 466 Query: 481 WNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKK 527 WNGMV EL+ KAD+A+APLTIT VRE+VIDFSKPFM+LGISI+ +K Sbjct: 467 WNGMVRELIDHKADLAVAPLTITYVREKVIDFSKPFMTLGISILYRK 513 Score = 177 bits (449), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 91/196 (46%), Positives = 132/196 (67%), Gaps = 7/196 (3%) Query: 649 RMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTA 708 R +PI+SA+DL+KQT+I YG ++ GST FF++SKI+ +DKMW +M S SV V+++ Sbjct: 512 RKGTPIDSADDLAKQTKIEYGAVEDGSTMTFFKKSKISTYDKMWAFMSSRRQSVLVKSSE 571 Query: 709 EGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVN 768 EG+ RV S YA L+EST E++ QR C+ ++GG +DSKGYG+ TP GS R+ + Sbjct: 572 EGIQRVLTS--DYALLMESTTIEFVTQRN-CNLTQIGGLIDSKGYGVGTPMGSPYRDKIT 628 Query: 769 LAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAM 828 +A+L+L E+G L +K KWW G C +SKE SAL + N+ G+F +L GL L++ Sbjct: 629 IAILQLQEEGKLHMMKEKWWRGNG-CPE--EESKE-ASALGVQNIGGIFIVLAAGLVLSV 684 Query: 829 LVALIEFCYKSRAEAK 844 VA+ EF YKS+ A+ Sbjct: 685 FVAVGEFLYKSKKNAQ 700 >5O9A-A nrPDB Length = 264 Score = 297 bits (760), Expect = 1e-80, Method: Compositional matrix adjust. Identities = 143/146 (97%), Positives = 145/146 (99%) Query: 652 SPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGV 711 +PIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGV Sbjct: 119 TPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGV 178 Query: 712 ARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAV 771 ARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSL NAVNLAV Sbjct: 179 ARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAV 238 Query: 772 LKLNEQGLLDKLKNKWWYDKGECGSG 797 LKL+EQGLLDKLKNKWWYDKGECGSG Sbjct: 239 LKLSEQGLLDKLKNKWWYDKGECGSG 264 Score = 238 bits (607), Expect = 9e-63, Method: Compositional matrix adjust. Identities = 114/115 (99%), Positives = 114/115 (99%) Query: 413 NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYG 472 NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYG Sbjct: 3 NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYG 62 Query: 473 ARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKK 527 ARDADTKIWNGMVGELVYGKADIAIAPLTIT VREEVIDFSKPFMSLGISIMIKK Sbjct: 63 ARDADTKIWNGMVGELVYGKADIAIAPLTITYVREEVIDFSKPFMSLGISIMIKK 117 >3FAT-A nrPDB Length = 260 Score = 280 bits (715), Expect = 2e-75, Method: Compositional matrix adjust. Identities = 131/144 (90%), Positives = 140/144 (97%) Query: 652 SPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGV 711 +PIESAEDL+KQTEIAYGTLDSGSTKEFFRRSKIAV++KMWTYMRSAEPSVF RTTAEGV Sbjct: 117 TPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGV 176 Query: 712 ARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAV 771 ARVRKSKGK+A+LLESTMNEYIEQRKPCDTMKVGGNLDSKGYG+ATPKGSSLR VNLAV Sbjct: 177 ARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAV 236 Query: 772 LKLNEQGLLDKLKNKWWYDKGECG 795 LKL+E G+LDKLKNKWWYDKGECG Sbjct: 237 LKLSEAGVLDKLKNKWWYDKGECG 260 Score = 213 bits (543), Expect = 2e-55, Method: Compositional matrix adjust. Identities = 101/114 (88%), Positives = 108/114 (94%) Query: 414 KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGA 473 +TVVVTTI+ESPYVM KKNHEM EGN++YEGYCVDLA+EIAKH G KYK+ IV DGKYGA Sbjct: 2 RTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGA 61 Query: 474 RDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKK 527 RDADTKIWNGMVGELVYGKA+IAIAPLTITLVREEVIDFSKPFMSLGISIMIKK Sbjct: 62 RDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKK 115 >3DP4-A nrPDB Length = 278 Score = 272 bits (696), Expect = 4e-73, Method: Compositional matrix adjust. Identities = 126/144 (87%), Positives = 140/144 (97%) Query: 652 SPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGV 711 +PIESAEDL+KQTEIAYGTLDSGSTKEFFRRSKIAV++KMW+YM+SAEPSVF +TTA+GV Sbjct: 135 TPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGV 194 Query: 712 ARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAV 771 ARVRKSKGK+A+LLESTMNEYIEQRKPCDTMKVGGNLDSKGYG+ATPKGS+L VNLAV Sbjct: 195 ARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAV 254 Query: 772 LKLNEQGLLDKLKNKWWYDKGECG 795 LKL+EQG+LDKLKNKWWYDKGECG Sbjct: 255 LKLSEQGILDKLKNKWWYDKGECG 278 Score = 219 bits (558), Expect = 4e-57, Method: Compositional matrix adjust. Identities = 105/122 (86%), Positives = 112/122 (91%) Query: 406 NDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTI 465 ND+S N+T+VVTTILESPYVM KKNHE LEGNERYEGYCVDLA EIAKH KYKL+I Sbjct: 12 NDSSRGANRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSI 71 Query: 466 VGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMI 525 VGDGKYGARD +TKIWNGMVGELVYG+ADIA+APLTITLVREEVIDFSKPFMSLGISIMI Sbjct: 72 VGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMI 131 Query: 526 KK 527 KK Sbjct: 132 KK 133 >5FXI-A nrPDB Length = 846 Score = 241 bits (616), Expect = 8e-64, Method: Compositional matrix adjust. Identities = 179/600 (29%), Positives = 298/600 (49%), Gaps = 81/600 (13%) Query: 294 KYTSALTYDAVQVMTEAFRNL-RKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQ 352 K SA DAV V+ +A L K+ I RG C+ N + W G +R L + Sbjct: 274 KNESAHISDAVGVVAQAVHELLEKENITDPPRG----CVGNTNI-WKTGPLFKRVLMSSK 328 Query: 353 -VEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEV-----DKMVV---TLTELP 403 +G++G ++F+++G R +IM L+ ++G ++ D+ ++ TE P Sbjct: 329 YADGVTGRVEFNEDGDRKFAQYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKP 388 Query: 404 SGNDTSGLENKTVVVTTILESPYVMMKKN-------------------------HEMLEG 438 G S + + TI + P+V +K ++ G Sbjct: 389 RGYQMS----TRLKIVTIHQEPFVYVKPTMSDGTCKEEFTVNGDPVKKVICTGPNDTSPG 444 Query: 439 NERYE------GYCVDLAAEIAKHCGFKYKLTIVGDGKYGARD----ADTKIWNGMVGEL 488 + R+ G+C+DL ++A+ F Y++ +V DGK+G ++ ++ K WNGM+GEL Sbjct: 445 SPRHTVPQCCYGFCIDLLIKLARTMQFTYEVHLVADGKFGTQERVQNSNKKEWNGMMGEL 504 Query: 489 VYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWM 548 + G+AD+ +APLTI R + I+FSKPF G++I++KK + + + SF+ P +W+ Sbjct: 505 LSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKK-EIPRSTLDSFMQPFQSTLWL 563 Query: 549 CIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQ 608 + + V+V+L+L+ RFSP F + SEST+ + +++WFS G + Sbjct: 564 LVGLSVHVVAVMLYLLDRFSP-------FGRFKVNSQSESTDALTLSSAMWFSWGVLLNS 616 Query: 609 GC-DISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED---LSKQT 664 G + +PRS S RI+G VW F +II++SYTANLAAFL ++R I D + Sbjct: 617 GIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSD 676 Query: 665 EIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYL 724 + Y T+ S +FRR M+ +M + AE + VR +K +A++ Sbjct: 677 KFIYATVKQSSVDIYFRRQ--VELSTMYRHMEKHN----YESAAEAIQAVRDNK-LHAFI 729 Query: 725 LESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLK 784 +S + E+ E + CD + G G+GI K S + V+L++LK +E G ++ L Sbjct: 730 WDSAVLEF-EASQKCDLVTTGELFFRSGFGIGMRKDSPWKQQVSLSILKSHENGFMEDL- 787 Query: 785 NKWWYDKGECGSGGGDSKEKTSA-LSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEA 843 +K W EC DS+ A L+ N+AGVF ++ GG+ + + IE YK +A Sbjct: 788 DKTWVRYQEC-----DSRSNAPATLTCENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDA 842 >5UOW-A nrPDB Length = 814 Score = 235 bits (599), Expect = 8e-62, Method: Compositional matrix adjust. Identities = 176/595 (29%), Positives = 291/595 (48%), Gaps = 83/595 (13%) Query: 294 KYTSALTYDAVQVMTEAFRNL-RKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQ 352 K SA DAV V+ +A L ++I RG C+ N + W G +R L + Sbjct: 253 KNESAHISDAVAVVAQAIHELFEMEQITDPPRG----CVGNTNI-WKTGPLFKRVLMSSK 307 Query: 353 V-EGLSGNIKFDQNGKRINYTINIMELKTNGPRKIG-----YWSEVDKMVV---TLTELP 403 +G++G I+F+++G R +IM L+ ++G Y + D+ ++ TE P Sbjct: 308 YPDGVTGRIEFNEDGDRKFAQYSIMNLQNRKLVQVGIFDGSYIIQNDRKIIWPGGETERP 367 Query: 404 SGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYE-------------------- 443 G S + + TI + P+V ++ E Y Sbjct: 368 QGYQMS----TRLKIVTIHQEPFVYVRPTTSDGTCREEYTINGDPIKKVICNGPDETIPG 423 Query: 444 ---------GYCVDLAAEIAKHCGFKYKLTIVGDGKYGARD----ADTKIWNGMVGELVY 490 G+CVDL ++A+ F Y++ +V DGK+G ++ ++ WNGM+GEL+ Sbjct: 424 RPTVPQCCYGFCVDLLIKLAREMDFTYEVHLVADGKFGTQERVNNSNAAAWNGMMGELLS 483 Query: 491 GKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCI 550 G+AD+ +APLTI R + I+FSKPF G++I++KK + + + SF+ P +W+ + Sbjct: 484 GQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKK-EIPRSTLDSFMQPFQSTLWLLV 542 Query: 551 VFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNE--FGIFNSLWFSLGAFMQQ 608 + V+V+L+L+ RFSP+ GR +S + E + +++WFS + Sbjct: 543 GLSVHVVAVMLYLLDRFSPF---------GRFKVNSAAAEEDALTLSSAMWFSWRVLLNS 593 Query: 609 GC-DISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVER---MVSPIESAEDLSKQT 664 G + +PRS S RI+G VW F +II++SYTANLAAFL + R ++ I + Sbjct: 594 GLGEGAPRSFSARILGMVWALFAMIIVASYTANLAAFLVLRRPEERITGINDPRLRNPSD 653 Query: 665 EIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYL 724 + Y T+ S +FRR M+ +M + AE + VR +K +A++ Sbjct: 654 KFIYATVKQSSVDIYFRRQ--VELSTMYRHMEKHN----YESAAEAIQAVRDNK-LHAFI 706 Query: 725 LESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLK 784 +S + E+ E + CD + G G+GI K S + V+L +LK +E G +++L Sbjct: 707 WDSAVLEF-EASQDCDLVTTGELFFRSGFGIGMRKDSPWKQEVSLNILKSHENGFMEEL- 764 Query: 785 NKWWYDKGECGSGGGDSKEKTSA-LSLSNVAGVFYILVGGLGLAMLVALIEFCYK 838 +K W EC DS+ A L+ N+AGVFY++ GG+ + + IE YK Sbjct: 765 DKTWVRYQEC-----DSRSNAPATLTFENMAGVFYLVAGGIVAGIFLIFIEIAYK 814 >5UN1-G nrPDB Length = 451 Score = 229 bits (583), Expect = 6e-60, Method: Compositional matrix adjust. Identities = 143/413 (34%), Positives = 225/413 (54%), Gaps = 39/413 (9%) Query: 444 GYCVDLAAEIAKHCGFKYKLTIVGDGKYGARD----ADTKIWNGMVGELVYGKADIAIAP 499 G+CVDL ++A+ F Y++ +V DGK+G ++ ++ WNGM+GEL+ G+AD+ +AP Sbjct: 62 GFCVDLLIKLAREMDFTYEVHLVADGKFGTQERVNNSNAAAWNGMMGELLSGQADMIVAP 121 Query: 500 LTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSV 559 LTI R + I+FSKPF G++I++KK + + + SF+ P +W+ + + V+V Sbjct: 122 LTINNERAQYIEFSKPFKYQGLTILVKK-EIPRSTLDSFMQPFQSTLWLLVGLSVHVVAV 180 Query: 560 VLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGC-DISPRSLS 618 +L+L+ RFSP+ FED S ++WFS + G + +PRS S Sbjct: 181 MLYLLDRFSPF----GRFEDALTLSS-----------AMWFSWRVLLNSGLGEGAPRSFS 225 Query: 619 GRIVGGVWWFFTLIIISSYTANLAAFLTVER---MVSPIESAEDLSKQTEIAYGTLDSGS 675 RI+G VW F +II++SYTANLAAFL + R ++ I + + Y T+ S Sbjct: 226 ARILGMVWAGFAMIIVASYTANLAAFLVLRRPEERITGINDPRLRNPSDKFIYATVKQSS 285 Query: 676 TKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQ 735 +FRR M+ +M + AE + VR +K +A++ +S + E+ E Sbjct: 286 VDIYFRRQ--VELSTMYRHMEKHN----YESAAEAIQAVRDNK-LHAFIWDSAVLEF-EA 337 Query: 736 RKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECG 795 + CD + G G+GI K S + V+L +LK +E G +++L +K W EC Sbjct: 338 SQKCDLVTTGELFFRSGFGIGMRKDSPWKQEVSLNILKSHENGFMEEL-DKTWVRYQEC- 395 Query: 796 SGGGDSKEKTSA-LSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMK 847 DS+ A L+ N+AGVF ++ GG+ + + IE YKSRAEAKRMK Sbjct: 396 ----DSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKSRAEAKRMK 444 >5UN1-B nrPDB Length = 448 Score = 188 bits (478), Expect = 7e-48, Method: Compositional matrix adjust. Identities = 130/418 (31%), Positives = 217/418 (51%), Gaps = 45/418 (10%) Query: 443 EGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTI 502 +G+C+D+ +IAK F Y L +V +GK+G + +WNGM+GE+V +A +A+ LTI Sbjct: 56 KGFCIDILKKIAKTVKFTYDLYLVTNGKHGKKI--NGVWNGMIGEVVTKRAYMAVGSLTI 113 Query: 503 TLVREEVIDFSKPFMSLGISIMIKKPQKS-KPGVFSFLDPLAYEIW-MCIVFAYIGVSVV 560 R EV+DFS PF+ GIS+M+ + + P +FL+P + ++W M V I +V Sbjct: 114 NEERSEVVDFSVPFIETGISVMVSRSNGTVSPS--AFLEPFSADVWVMMFVMLLIVSAVA 171 Query: 561 LFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDI-SPRSLSG 619 +F+ FSP ++ F G+ ++W G + +P+ + Sbjct: 172 VFVFEYFSPVGYNGPSFTIGK---------------AIWLLWGLVFNNSLPVQNPKGTTS 216 Query: 620 RIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQ------TEIAYGTLDS 673 +I+ VW FF +I ++SYTANLAAF+ R V + D Q +GT+ + Sbjct: 217 KIMVSVWAFFAVIFLASYTANLAAFMIQRRYVDQVSGLSDKKFQRPNDFSPAFRFGTVPN 276 Query: 674 GSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYI 733 GST+ R + + +M +YM F + + + KS A++ ++ + Y+ Sbjct: 277 GSTERNIRNNYL----EMHSYMVK-----FNQRSVQDALLSLKSGKLDAFIYDAAVLNYM 327 Query: 734 EQR-KPCDTMKVGGN--LDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYD 790 R + C + +G + GYGIA K S + V+LA+L+L G +++L+ W Sbjct: 328 AGRDEGCKLVTIGSGKVFATTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWL-- 385 Query: 791 KGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIE-FCYKSRAEAKRMK 847 G C + ++ +S L + N+AGVFY+L + L+++ ++E YKSRAEAKRMK Sbjct: 386 TGICHN--EKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIMEHLFYKSRAEAKRMK 441 >6IRA-D nrPDB Length = 853 Score = 186 bits (472), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 181/695 (26%), Positives = 319/695 (45%), Gaps = 105/695 (15%) Query: 199 LELKK--ERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGAN 256 ++LKK ++L C +D+ I+ + ++G + +I+ +L + +L+ +F Sbjct: 217 VQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFP--- 273 Query: 257 VSGFQIVDYDDSLVSKFIERWS-TLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLR 315 SG V YDD W +LE + G T +S M E F + Sbjct: 274 -SGLISVSYDD---------WDYSLEARVRDGIGILTTAASS---------MLEKFSYIP 314 Query: 316 KQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINI 375 + + + + P VP + + V +G ++ F + G +++ + + Sbjct: 315 EAKASCYGQ------MERPEVPMHT---LHPFMVNVTWDG--KDLSFTEEGYQVHPRLVV 363 Query: 376 MEL-KTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLE--NKTVVVTTILESPYVMM--- 429 + L K K+G W E + + P S E + + + T+ E+P+V++ Sbjct: 364 IVLNKDREWEKVGKW-ENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDI 422 Query: 430 ------------------KKNHEMLEG---NERYEGYCVDLAAEIAKHCGFKYKLTIVGD 468 K N+ EG + +G+C+D+ ++++ F Y L +V + Sbjct: 423 DPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTN 482 Query: 469 GKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKP 528 GK+G + + +WNGM+GE+VY +A +A+ LTI R EV+DFS PF+ GIS+M+ + Sbjct: 483 GKHGKKVNN--VWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRS 540 Query: 529 QKS-KPGVFSFLDPLAYEIW-MCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSS 586 + P +FL+P + +W M V I ++ +F+ FSP ++ G+ Sbjct: 541 NGTVSPS--AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYN-RNLAKGKAPHGP 597 Query: 587 ESTNEFGIFNSLWFSLGAFMQQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAFL 645 F I ++W G + +P+ + +I+ VW FF +I ++SYTANLAAF+ Sbjct: 598 ----SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFM 653 Query: 646 TVERMVSPIESAEDLSKQ------TEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAE 699 R V + D Q +GT+ +GST+ R + + M YM Sbjct: 654 IQRRFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNN----YPYMHQYM---- 705 Query: 700 PSVFVRTTAEGV--ARVRKSKGKY-AYLLESTMNEYIEQR-KPCDTMKVGGN--LDSKGY 753 + +GV A V GK A++ ++ + Y R + C + +G + GY Sbjct: 706 ----TKFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGY 761 Query: 754 GIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNV 813 GIA KGS + ++LA+L+ G +++L+ W G C + ++ +S L + N+ Sbjct: 762 GIALQKGSPWKRQIDLALLQFVGDGEMEELETLWL--TGICHN--EKNEVMSSQLDIDNM 817 Query: 814 AGVFYILVGGLGLAMLVALIE-FCYKSRAEAKRMK 847 AGVFY+L + L+++ + E YKSRAEAKRMK Sbjct: 818 AGVFYMLAAAMALSLITFIWEHLFYKSRAEAKRMK 852 >5IPR-B nrPDB Length = 825 Score = 180 bits (456), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 187/797 (23%), Positives = 357/797 (44%), Gaps = 119/797 (14%) Query: 87 AIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLK---GALLSLIEYY 143 AI D SV T+T G S + + + + F Q P ++ +L+++E Y Sbjct: 102 AIAQILDFISVQTLTPILGIHGGSSMIMADKEEASMFF--QFGPSIEQQASVMLNIMEEY 159 Query: 144 QWDKFAYLYDSDRGLSTLQAVLDSAAEKK---WQVTAINVGNINNDKKDEMYRSLFQDLE 200 W F+ + G + + S E W++ + +++ D D ++ + L+ Sbjct: 160 DWYIFSIVTTYFPGYQDFENKVRSTIENSFVGWELEEVIHLDMSLDDIDSKIQNQLKKLQ 219 Query: 201 LKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGF 260 ++L C +++ I + ++G G+ +I+ +L D D + +F +G Sbjct: 220 ---SPVILLYCTKEEATYIFEVAHSVGLTGYGFTWIVPSLVAGDTDTVPDEFP----TGL 272 Query: 261 QIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIE 320 V YD+ W + + P A D + ++T A + + Sbjct: 273 ISVSYDE---------W----DYDLP-----------ARVRDGIAIITTAASTMLSEHNS 308 Query: 321 ISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKT 380 I + ++ + + V + ++R L V EG ++ F ++G +++ + I+ L Sbjct: 309 IPQSKSSCNNIQESRV--YEAHMLKRYLINVTFEG--RDLSFSEDGYQMHPKLVIILL-- 362 Query: 381 NGPRK---IGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMK------- 430 N RK +G + + + + +L ++ E+ ++V T+ E+P+V+++ Sbjct: 363 NQERKWERVGKYKDRSLKMWPVFDLYPNSEEHKDEHLSIV--TLEEAPFVIVEDVDPLSG 420 Query: 431 -------KNHEMLEGNERYE-----------GYCVDLAAEIAKHCGFKYKLTIVGDGKYG 472 + + R E G+C+D+ +IAK F Y L +V +GK+G Sbjct: 421 TCMRNTVPCRKQIRPENRTEEGGNYIKRCCKGFCIDILKKIAKTVKFTYDLYLVTNGKHG 480 Query: 473 ARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKS- 531 + +WNGM+GE+V +A +A+ LTI R EV+DFS PF+ GIS+M+ + + Sbjct: 481 KKI--NGVWNGMIGEVVTKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTV 538 Query: 532 KPGVFSFLDPLAYEIW-MCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTN 590 P +FL+P + ++W M V I +V +F+ FSP ++ F G+ Sbjct: 539 SPS--AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNGPSFTIGK--------- 587 Query: 591 EFGIFNSLWFSLGAFMQQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVER 649 ++W G + +P+ + +I+ VW FF +I ++SYTANLAAF+ R Sbjct: 588 ------AIWLLWGLVFNNSLPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQRR 641 Query: 650 MVSPIESAEDLSKQ------TEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVF 703 V + D Q +GT+ +GST+ R + + +M +YM F Sbjct: 642 YVDQVSGLSDKKFQRPNDFSPAFRFGTVPNGSTERNIRNNYL----EMHSYMVK-----F 692 Query: 704 VRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR-KPCDTMKVGGN--LDSKGYGIATPKG 760 + + + KS A++ ++ + Y+ R + C + +G + GYGIA K Sbjct: 693 NQRSVQDALLSLKSGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFATTGYGIAIQKD 752 Query: 761 SSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYIL 820 S + V+LA+L+L G +++L+ W G C + + +S L + N+AGVFY+L Sbjct: 753 SGWKRQVDLAILQLFGDGEMEELEALWL--TGICHNEKNEV--MSSQLDIDNMAGVFYML 808 Query: 821 VGGLGLAMLVALIEFCY 837 + L+++ ++E + Sbjct: 809 AAAMALSLITFIMEHLF 825 >4PE5-B nrPDB Length = 820 Score = 175 bits (444), Expect = 6e-44, Method: Compositional matrix adjust. Identities = 187/739 (25%), Positives = 329/739 (44%), Gaps = 104/739 (14%) Query: 136 LLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKK---WQVTAINVGNINNDKKDEMY 192 +L+++E Y W F+ + G + S E W++ + + +++ D D Sbjct: 131 MLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDCKI 190 Query: 193 RSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQF 252 ++ + L+ ++L C +++ I + ++G GY +I+ +L D D + +F Sbjct: 191 QNQLKKLQ---SPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPSEF 247 Query: 253 GGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFR 312 +G V YD E +Y A D + ++T A Sbjct: 248 P----TGLISVSYD---------------EWDYG---------LPARVRDGIAIITTAAS 279 Query: 313 NLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYT 372 ++ + I ++ C Q + R L V EG ++ F ++G +++ Sbjct: 280 DMLSEHSFIPEPKSS--CYNTHEKRIYQSNMLNRYLINVTFEG--RDLSFSEDGYQMHPK 335 Query: 373 INIMEL-KTNGPRKIGYW---------------SEVDKM-VVTLTELP-----SGNDTSG 410 + I+ L K ++G W ++ D + +VTL E P S + SG Sbjct: 336 LVIILLNKERKWERVGKWKDKSLQMKYYVWPRMTQDDHLSIVTLEEAPFVIVESVDPLSG 395 Query: 411 LENKTVVVTTILESPYVMMKKNHEMLEG--NERYEGYCVDLAAEIAKHCGFKYKLTIVGD 468 T + T+ ++ + + G + +G+C+D+ +I+K F Y L +V + Sbjct: 396 ----TCMRNTVPCQKRIISENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTN 451 Query: 469 GKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKP 528 GK+G + T WNGM+GE+V +A +A+ LTI R EV+DFS PF+ GIS+M+ + Sbjct: 452 GKHGKKINGT--WNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRS 509 Query: 529 QKS-KPGVFSFLDPLAYEIW-MCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSS 586 + P +FL+P + +W M V I +V +F+ FSP ++ DGRE Sbjct: 510 NGTVSPS--AFLEPFSACVWVMMFVMLLIVSAVAVFVFEYFSPVGYN-RSLADGREPGGP 566 Query: 587 ESTNEFGIFNSLWFSLGAFMQQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAFL 645 F I ++W G + +P+ + +I+ VW FF +I ++SYTANLAAF+ Sbjct: 567 ----SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFM 622 Query: 646 TVERMVSPIESAEDLSKQ------TEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAE 699 E V + D Q +GT+ +GST+ R + + +M YM Sbjct: 623 IQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNN----YAEMHAYMGK-- 676 Query: 700 PSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR-KPCDTMKVGGN--LDSKGYGIA 756 F + + K+ A++ ++ + Y+ R + C + +G S GYGIA Sbjct: 677 ---FNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIA 733 Query: 757 TPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGV 816 K S + V+LA+L+L G +++L+ W G C + + +S L N+AGV Sbjct: 734 IQKDSGWKRQVDLAILQLFGDGEMEELEALWL--TGICHNEKNEV--MSSQLDCDNMAGV 789 Query: 817 FYILVGGLGLAMLVALIEF 835 FY+ LG AM ++LI F Sbjct: 790 FYM----LGAAMALSLITF 804 >5DT6-A nrPDB Length = 267 Score = 173 bits (439), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 83/143 (58%), Positives = 106/143 (74%), Gaps = 1/143 (0%) Query: 652 SPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGV 711 +PI++ EDL+ QT++ YGTL GST EFFRRS+I + +KMW YM +A V T EG+ Sbjct: 125 TPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-NANQHHSVHTYDEGI 183 Query: 712 ARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAV 771 RVR+SKGKYA L+ES NEY+ R PCDTMKVG N+D+KG+G+ATP GS LR +N AV Sbjct: 184 RRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAV 243 Query: 772 LKLNEQGLLDKLKNKWWYDKGEC 794 L L E G L +++NKWW+DK EC Sbjct: 244 LTLKENGELLRIRNKWWFDKTEC 266 Score = 126 bits (317), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 65/118 (55%), Positives = 85/118 (72%), Gaps = 3/118 (2%) Query: 413 NKTVVVTTILESPYVMMKKNH--EMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGK 470 N T +V+++LE PY+ +K+ E L GN+R+EGYC DLA +A G KY++ +V DG Sbjct: 6 NHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGN 65 Query: 471 YGARDADTKI-WNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKK 527 YGA + W+GMVGEL+ +ADIAI+ +TIT RE VIDFSKPFM+LGISIMIKK Sbjct: 66 YGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKK 123 >5UP2-B nrPDB Length = 831 Score = 172 bits (436), Expect = 5e-43, Method: Compositional matrix adjust. Identities = 178/754 (23%), Positives = 330/754 (43%), Gaps = 124/754 (16%) Query: 135 ALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKK---WQVTAINVGNINNDKKDEM 191 +L+++E Y W F+ + + G + + + + W+V N D Sbjct: 149 VMLNIMEEYDWHVFSVITSNFPGYRDFISFIKTTVDNSFVGWEVQ-------NYITLDTS 201 Query: 192 YRSLFQDLELKKERR--VILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLK 249 Y +LKK ++L C +D+ I ++ ++G G+ +I+ +L + D++ Sbjct: 202 YTDAQTLTQLKKIHSSVILLYCSKDEATYIFEEARSLGLMGYGFVWIVPSLVTGNTDIIP 261 Query: 250 IQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTE 309 +F SG V YDD W E A D + ++T Sbjct: 262 YEFP----SGLVSVSYDD---------WDYGIE---------------ARVRDGLGIITT 293 Query: 310 AFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALK-----QVQVEGLSGNIKFDQ 364 A + ++ I + C +GQ + L + V ++ F + Sbjct: 294 AASAMLEKHSVIPEAKTS--C-------YGQNERNDPPLHTLHNFMINVTWDGKDLSFTE 344 Query: 365 NGKRINYTINIMELKTNGP-RKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILE 423 +G + N + ++ L K+G W E + + P + S ++ + + T+ E Sbjct: 345 DGYQANPKLVVLLLNMEREWEKVGKW-EAKSLNMKYPVWPRID--SDHDDNHLSIVTLEE 401 Query: 424 SPYVMMKKNHEMLEGN--------ERY-----------------EGYCVDLAAEIAKHCG 458 +P+V+++ N + L G +Y +G+C+D+ +++K Sbjct: 402 APFVIVE-NIDYLTGTCVRNTVPCRKYFRLANSTTEGTSVKKCCKGFCIDILKKLSKTVK 460 Query: 459 FKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMS 518 F Y L +V +GK+G + + +WNGM+GE+VY +A +A+ LTI R +DFS PF+ Sbjct: 461 FTYDLYLVTNGKHGKKIKN--VWNGMIGEVVYKRAVMAVGSLTINEERSVAVDFSVPFVE 518 Query: 519 LGISIMIKKPQKS-KPGVFSFLDPLAYEIW-MCIVFAYIGVSVVLFLVSRFSPYEWHTEE 576 GIS+M+ + + P +FL+P + +W M V + ++ +F+ FSP ++ Sbjct: 519 TGISVMVSRSAGTVSPS--AFLEPFSASVWVMMFVMLLLVSAMAVFIFEYFSPVGYN-RN 575 Query: 577 FEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDI-SPRSLSGRIVGGVWWFFTLIIIS 635 G++ F I ++W G + +P+ + +I+ +W FF +I ++ Sbjct: 576 LAQGKDPHGP----SFTIGKAVWLLWGLVFNNSLPVQNPKGTTSKIIVSIWAFFAVIFLA 631 Query: 636 SYTANLAAFLTVERMVSPIESAEDLSKQTEIAY------GTLDSGSTKEFFRRSKIAVFD 689 SYTANLAAF+ R V + D Q Y GT+ GST+ R + + Sbjct: 632 SYTANLAAFMIQRRFVDQVTGLSDNKFQRPHDYSPPFRFGTVPQGSTERNIRNN----YP 687 Query: 690 KMWTYMRSAEPSVFVRTTAEGV--ARVRKSKGKY-AYLLESTMNEYIEQR-KPCDTMKVG 745 M YM V+ +GV A V GK A++ ++ + Y+ R + C + +G Sbjct: 688 DMHQYM--------VKFHQKGVQDALVSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIG 739 Query: 746 GN--LDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKE 803 + GYGIA KGS + ++LA+L+ G +++L+ W G C + ++ Sbjct: 740 SGYIFATTGYGIALQKGSRWKRPIDLALLQFVGDGEMEELEKLWL--TGICHT--EKNEV 795 Query: 804 KTSALSLSNVAGVFYILVGGLGLAMLVALIEFCY 837 +S L + N+AGVFY+L + L+++ + E + Sbjct: 796 MSSQLDIDNMAGVFYMLAAAMALSLITFVWEHLF 829 >1YAE-A nrPDB Length = 312 Score = 170 bits (430), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 79/135 (58%), Positives = 104/135 (77%) Query: 406 NDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTI 465 N T L N++++VTTILE PYV+ KK+ + L GN+R+EGYC+DL E++ GF Y++ + Sbjct: 5 NITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRL 64 Query: 466 VGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMI 525 V DGKYGA+D WNGMV EL+ KAD+A+APL IT VRE+VIDFSKPFM+LGISI+ Sbjct: 65 VEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILY 124 Query: 526 KKPQKSKPGVFSFLD 540 +KP + PGVFSFL+ Sbjct: 125 RKPNGTNPGVFSFLN 139 Score = 153 bits (387), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 76/165 (46%), Positives = 111/165 (67%), Gaps = 7/165 (4%) Query: 648 ERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTT 707 ERM SPI+SA+DL+KQT+I YG ++ G+T FF++SKI+ +DKMW +M S SV V++ Sbjct: 149 ERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSN 208 Query: 708 AEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAV 767 EG+ RV S YA+L+EST E++ QR C+ ++GG +DSKGYG+ TP GS R+ + Sbjct: 209 EEGIQRVLTS--DYAFLMESTTIEFVTQRN-CNLTQIGGLIDSKGYGVGTPMGSPYRDKI 265 Query: 768 NLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSN 812 +A+L+L E+G L +K KWW G C + ++ SAL + N Sbjct: 266 TIAILQLQEEGKLHMMKEKWWRGNG-CPE---EESKEASALGVQN 306 >5EHM-A nrPDB Length = 268 Score = 166 bits (419), Expect = 5e-41, Method: Compositional matrix adjust. Identities = 82/149 (55%), Positives = 102/149 (68%), Gaps = 4/149 (2%) Query: 649 RMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTA 708 R +PIESAEDL+KQT I YG L GST FFR SKI+ + +MW++M SA PSVF + Sbjct: 120 RKGTPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTASNG 179 Query: 709 EGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVN 768 EGV RV K KG YA+L+EST EY+ +R C+ +VGG LD+K YGIATP S R A+N Sbjct: 180 EGVERVAKGKGSYAFLMESTSIEYVTERN-CELTQVGGMLDTKSYGIATPPNSPYRTAIN 238 Query: 769 LAVLKLNEQGLLDKLKNKWWYDK---GEC 794 +LKL E+G L LK KWW +K G+C Sbjct: 239 SVILKLQEEGKLHILKTKWWKEKRGGGKC 267 Score = 134 bits (337), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 63/120 (52%), Positives = 89/120 (74%) Query: 408 TSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVG 467 ++ L+NKT+VVTTIL +PY M K++ L GN+++EGY VDL EI+K GF YK+ +V Sbjct: 2 SANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLIHEISKSLGFNYKIQLVP 61 Query: 468 DGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKK 527 DG YG+ + T WNGM+ EL+ +AD+AIA LTIT RE+ +DF+ PFM+LG+SI+ +K Sbjct: 62 DGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSILYRK 121 >5L2E-A nrPDB Length = 688 Score = 165 bits (417), Expect = 9e-41, Method: Compositional matrix adjust. Identities = 136/546 (24%), Positives = 245/546 (44%), Gaps = 58/546 (10%) Query: 23 SSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEF-----RLTPHIDNLEVANSFAVTNAF 77 S + I IG +F A ++ FR + + +E ++T + ++ N F Sbjct: 2 SDSIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEA 61 Query: 78 CSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGT-------------HPF 124 C ++G+ A+ S ++ S +H+ + T GT + Sbjct: 62 CELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDY 121 Query: 125 VIQMRPD--LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINV-G 181 + +RP L +L ++ Y W KF YDS+ + +Q LD +++ V V Sbjct: 122 TLSVRPPVYLNEVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVEN 181 Query: 182 NINNDKKDEMYRSLFQDLELKKE-------RRVILDCERDKVNDIVDQVITIGKHVKGYH 234 NIN +M +LF + +++ RR IL + +V+ H Sbjct: 182 NIN-----KMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFISEVVETNLVAFDCH 236 Query: 235 YIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERW--------STLEEKEYP 286 +II N D D+ ++ ++ I+ + +R STL + + P Sbjct: 237 WIIINEEINDVDVQELV--RRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDP 294 Query: 287 GAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIER 346 A I ++ YD V ++ AF + R S + C+ + PW G + Sbjct: 295 FAQNMEI--SNLYIYDTVLLLANAFHKKLQDRKWHSMASLS--CIRKNSKPWQGGRSMLE 350 Query: 347 ALKQVQVEGLSGNIKFDQNGKRINYTINIM-----ELKTNGPRKIGYWSEVDKMVVTLTE 401 +K+ V GL+G+++F +NG N I+ E G RK+G W+ V + +LT+ Sbjct: 351 TIKKGGVNGLTGDLEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTD 410 Query: 402 LPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKY 461 N+ G+ + V T+LE P+VM+ +N +L ++Y+G+ +D+ ++ + GF Y Sbjct: 411 KKLENNMRGV---VLRVVTVLEEPFVMVSEN--VLGKPKKYQGFSIDVLDALSNYLGFNY 465 Query: 462 KLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGI 521 ++ + D KYG+ D WNG+VGELV+ +ADI I+ LTIT RE V+DF+ +M + Sbjct: 466 EIYVAPDHKYGSPQED-GTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSV 524 Query: 522 SIMIKK 527 +++++ Sbjct: 525 GVLLRR 530 Score = 83.6 bits (205), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 50/154 (32%), Positives = 81/154 (52%), Gaps = 10/154 (6%) Query: 649 RMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDK------MWTYM-RSAEPS 701 R + I+S +DLSKQT+I YGT+ + + R + F++ MW + RS Sbjct: 529 RRGTSIQSLQDLSKQTDIPYGTVLDSAVYQHVRMKGLNPFERDSMYSQMWRMINRSNGSE 588 Query: 702 VFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKP-CDTMKVGGNLDSKGYGIATPKG 760 V + G+ +V+ G YA++ ++ + EY+ P C VG + +GYGIA G Sbjct: 589 NNVLESQAGIQKVKY--GNYAFVWDAAVLEYVAINDPDCSFYTVGNTVADRGYGIALQHG 646 Query: 761 SSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGEC 794 S R+ + +L+L + G +D LK+KWW G+C Sbjct: 647 SPYRDVFSQRILELQQSGDMDILKHKWWPKNGQC 680 >5IKB-A nrPDB Length = 257 Score = 152 bits (384), Expect = 5e-37, Method: Compositional matrix adjust. Identities = 75/146 (51%), Positives = 100/146 (68%), Gaps = 4/146 (2%) Query: 649 RMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTA 708 R +PIES +DL+ QT I YGT+ GS+ FF+ S+ + +MW YM S +PSVFV++T Sbjct: 115 RKGTPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTE 174 Query: 709 EGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVN 768 EG+ARV S YA+LLESTMNEY QR C+ ++GG LD+KGYGI P GS R+ + Sbjct: 175 EGIARVLNS--NYAFLLESTMNEYYRQRN-CNLTQIGGLLDTKGYGIGMPVGSVFRDEFD 231 Query: 769 LAVLKLNEQGLLDKLKNKWWYDKGEC 794 LA+L+L E L+ LK KWW + G+C Sbjct: 232 LAILQLQENNRLEILKRKWW-EGGKC 256 Score = 150 bits (380), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 81/161 (50%), Positives = 111/161 (68%), Gaps = 10/161 (6%) Query: 413 NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYG 472 N T+VVTTILE+PY+M+K NH+ +EGN+RYEG+CVD+ E+A+ F YK+ +VGDG YG Sbjct: 3 NTTLVVTTILENPYLMLKGNHQDMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYG 62 Query: 473 ARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKK--PQK 530 +A+ W GMVGEL+ KAD+A+A LTIT RE+VIDFSKPFM+LGISI+ +K P + Sbjct: 63 VPEAN-GTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRKGTPIE 121 Query: 531 SKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYE 571 S +D LA + + + G S+ F SR+ Y+ Sbjct: 122 S-------VDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQ 155 >2XXT-A nrPDB Length = 261 Score = 147 bits (372), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 85/186 (45%), Positives = 115/186 (61%), Gaps = 14/186 (7%) Query: 413 NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYG 472 N++++VTTILE PYV+ KK+ + L GN+R+EGYC+DL E++ GF Y++ +V DGKYG Sbjct: 3 NRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYG 62 Query: 473 ARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKK--PQK 530 A+D WNGMV EL+ KAD+A+APL IT VRE+VIDFSKPFM+LGISI+ +K P Sbjct: 63 AQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKGTPID 122 Query: 531 SKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYE--WHTEEFEDGRETQSSES 588 S D LA + + G ++ F S+ S Y+ W F R Sbjct: 123 SA-------DDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWA---FMSSRRQSVLVK 172 Query: 589 TNEFGI 594 +NE GI Sbjct: 173 SNEEGI 178 Score = 146 bits (368), Expect = 5e-35, Method: Compositional matrix adjust. Identities = 68/144 (47%), Positives = 100/144 (69%), Gaps = 3/144 (2%) Query: 649 RMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTA 708 R +PI+SA+DL+KQT+I YG ++ G+T FF++SKI+ +DKMW +M S SV V++ Sbjct: 116 RKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNE 175 Query: 709 EGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVN 768 EG+ RV S YA+L+EST E++ QR C+ ++GG +DSKGYG+ TP GS R+ + Sbjct: 176 EGIQRVLTS--DYAFLMESTTIEFVTQRN-CNLTQIGGLIDSKGYGVGTPMGSPYRDKIT 232 Query: 769 LAVLKLNEQGLLDKLKNKWWYDKG 792 +A+L+L E+G L +K KWW G Sbjct: 233 IAILQLQEEGKLHMMKEKWWRGNG 256 >4MF3-A nrPDB Length = 261 Score = 147 bits (371), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 81/163 (49%), Positives = 109/163 (66%), Gaps = 10/163 (6%) Query: 411 LENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGK 470 L N+T++VTTILE PYVM +K+ + L GN+R+EGYC+DL E++ GF Y + +V DGK Sbjct: 2 LANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGK 61 Query: 471 YGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKK--P 528 YGA++ D WNGMV EL+ +AD+A+APLTIT VRE+VIDFSKPFM+LGISI+ +K P Sbjct: 62 YGAQN-DKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKGTP 120 Query: 529 QKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYE 571 S D LA + + G ++ F S+ S YE Sbjct: 121 IDSA-------DDLAKQTKIEYGAVRDGSTMTFFKKSKISTYE 156 Score = 141 bits (355), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 67/144 (46%), Positives = 98/144 (68%), Gaps = 3/144 (2%) Query: 649 RMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTA 708 R +PI+SA+DL+KQT+I YG + GST FF++SKI+ ++KMW +M S + + VR + Sbjct: 116 RKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSD 175 Query: 709 EGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVN 768 EG+ RV + YA L+EST EY+ QR C+ ++GG +DSKGYG+ TP GS R+ + Sbjct: 176 EGIQRVLTT--DYALLMESTSIEYVTQRN-CNLTQIGGLIDSKGYGVGTPIGSPYRDKIT 232 Query: 769 LAVLKLNEQGLLDKLKNKWWYDKG 792 +A+L+L E+G L +K KWW G Sbjct: 233 IAILQLQEEGKLHMMKEKWWRGNG 256 >4IGR-A nrPDB Length = 258 Score = 146 bits (369), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 67/115 (58%), Positives = 91/115 (79%), Gaps = 1/115 (0%) Query: 413 NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYG 472 N++++VTT+LE P+VM +K+ L GN+R+EGYC+DL E+A GF Y++ +V DGKYG Sbjct: 5 NRSLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYG 64 Query: 473 ARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKK 527 A+D D WNGMV EL+ KAD+A+APLTIT VRE+ IDFSKPFM+LG+SI+ +K Sbjct: 65 AQD-DKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRK 118 Score = 139 bits (349), Expect = 8e-33, Method: Compositional matrix adjust. Identities = 68/144 (47%), Positives = 97/144 (67%), Gaps = 4/144 (2%) Query: 649 RMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTA 708 R +PI+SA+DL+KQT+I YG + G+T FF++SKI+ F+KMW +M S++PS V+ Sbjct: 117 RKGTPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFM-SSKPSALVKNNE 175 Query: 709 EGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVN 768 EG+ R + YA L+EST EYI QR C+ ++GG +DSKGYGI TP GS R+ + Sbjct: 176 EGIQRTLTA--DYALLMESTTIEYITQRN-CNLTQIGGLIDSKGYGIGTPMGSPYRDKIT 232 Query: 769 LAVLKLNEQGLLDKLKNKWWYDKG 792 +A+L+L E+ L +K KWW G Sbjct: 233 IAILQLQEEDKLHIMKEKWWRGSG 256 >4WXJ-A nrPDB Length = 269 Score = 100 bits (248), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 51/137 (37%), Positives = 80/137 (58%), Gaps = 1/137 (0%) Query: 652 SPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGV 711 + I S DL Q ++ +GT+ G+T +F S W M S +P F + EGV Sbjct: 126 TDIGSLHDLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGV 185 Query: 712 ARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAV 771 RV+ SKG YA+L+E+T +Y QR C+ ++G + K YGIA P + R+ +++ + Sbjct: 186 DRVKLSKGTYAFLMETTNLQYYVQRN-CELTQIGESFGEKHYGIAVPLNADFRSNLSVGI 244 Query: 772 LKLNEQGLLDKLKNKWW 788 L+L+E+G L KL+NKW+ Sbjct: 245 LRLSERGELFKLRNKWF 261 Score = 99.8 bits (247), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 50/113 (44%), Positives = 68/113 (60%), Gaps = 2/113 (1%) Query: 417 VVTTILESPYVMMKKNHEML--EGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGAR 474 V T + PY ++ E + EGNER+EGY VDL +A+ C F + V D KYG+ Sbjct: 12 TVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSY 71 Query: 475 DADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKK 527 DA+T W+G++ +L+ A I I LTIT R V+DF+ PFM LGISI+ K Sbjct: 72 DANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYK 124 >5CC2-A nrPDB Length = 265 Score = 93.2 bits (230), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 42/110 (38%), Positives = 73/110 (66%), Gaps = 3/110 (2%) Query: 418 VTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDAD 477 V T+LE P+VM+ +N +L ++Y+G+ +D+ ++ + GF Y++ + D KYG+ D Sbjct: 7 VVTVLEEPFVMVSEN--VLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQED 64 Query: 478 TKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKK 527 WNG+VGELV+ +ADI I+ LTIT RE V+DF+ +M + +++++ Sbjct: 65 -GTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLRR 113 Score = 84.3 bits (207), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 50/154 (32%), Positives = 81/154 (52%), Gaps = 10/154 (6%) Query: 649 RMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDK------MWTYM-RSAEPS 701 R + I+S +DLSKQT+I YGT+ + + R + F++ MW + RS Sbjct: 112 RRGTSIQSLQDLSKQTDIPYGTVLDSAVYQHVRMKGLNPFERDSMYSQMWRMINRSNGSE 171 Query: 702 VFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKP-CDTMKVGGNLDSKGYGIATPKG 760 V + G+ +V+ G YA++ ++ + EY+ P C VG + +GYGIA G Sbjct: 172 NNVLESQAGIQKVKY--GNYAFVWDAAVLEYVAINDPDCSFYTVGNTVADRGYGIALQHG 229 Query: 761 SSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGEC 794 S R+ + +L+L + G +D LK+KWW G+C Sbjct: 230 SPYRDVFSQRILELQQSGDMDILKHKWWPKNGQC 263 >5I2K-B nrPDB Length = 293 Score = 89.0 bits (219), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 39/88 (44%), Positives = 63/88 (71%), Gaps = 4/88 (4%) Query: 444 GYCVDLAAEIAKHCGFKYKLTIVGDGKYGARD----ADTKIWNGMVGELVYGKADIAIAP 499 G+C+DL ++A+ F Y++ +V DGK+G ++ ++ K WNGM+GEL+ G+AD+ +AP Sbjct: 66 GFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAP 125 Query: 500 LTITLVREEVIDFSKPFMSLGISIMIKK 527 LTI R + I+FSKPF G++I++KK Sbjct: 126 LTINNERAQYIEFSKPFKYQGLTILVKK 153 Score = 49.7 bits (117), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 37/129 (28%), Positives = 61/129 (47%), Gaps = 9/129 (6%) Query: 668 YGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLES 727 Y T+ S +FRR M+ +M + AE + VR +K +A++ +S Sbjct: 174 YATVKQSSVDIYFRRQ--VELSTMYRHMEKHN----YESAAEAIQAVRDNK-LHAFIWDS 226 Query: 728 TMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKW 787 + E+ E + CD + G G+GI K S + V+L++LK +E G ++ L +K Sbjct: 227 AVLEF-EASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDL-DKT 284 Query: 788 WYDKGECGS 796 W EC S Sbjct: 285 WVRYQECDS 293 >3OEK-A nrPDB Length = 286 Score = 84.0 bits (206), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 37/85 (43%), Positives = 57/85 (67%), Gaps = 2/85 (2%) Query: 443 EGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTI 502 +G+C+D+ +A GF Y L +V +GK+G + +WNGM+GE+ Y +AD+AI LTI Sbjct: 60 KGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKI--DGVWNGMIGEVFYQRADMAIGSLTI 117 Query: 503 TLVREEVIDFSKPFMSLGISIMIKK 527 R E++DFS PF+ GIS+M+ + Sbjct: 118 NEERSEIVDFSVPFVETGISVMVAR 142 Score = 37.7 bits (86), Expect = 0.020, Method: Compositional matrix adjust. Identities = 31/126 (24%), Positives = 65/126 (51%), Gaps = 14/126 (11%) Query: 666 IAYGTLDSGSTKEFFRRSKIAVFDKMWTYM-RSAEPSVFVRTTAEGVARVRKSKGKYAYL 724 + +GT+ +GST++ R + + M +YM R +P V E + +++ K A++ Sbjct: 164 LKFGTVPNGSTEKNIRSN----YPDMHSYMVRYNQPRV-----EEALTQLKAGKLD-AFI 213 Query: 725 LESTMNEYIEQR-KPCDTMKVGGN--LDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLD 781 ++ + Y+ ++ + C + +G + GYGIA KGS + ++LA+L+ ++ Sbjct: 214 YDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIE 273 Query: 782 KLKNKW 787 L+ W Sbjct: 274 MLERLW 279 >2RCB-A nrPDB Length = 292 Score = 81.3 bits (199), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 37/84 (44%), Positives = 55/84 (65%), Gaps = 4/84 (4%) Query: 444 GYCVDLAAEIAKHCGFKYKLTIVGDGKYGA-RDADTKIWNGMVGELVYGKADIAIAPLTI 502 GYC+DL +A+ F ++L IVGDGKYGA RD W G+VG+L+ G+A +A+ +I Sbjct: 68 GYCIDLLERLAEDLAFDFELYIVGDGKYGALRDGR---WTGLVGDLLAGRAHMAVTSFSI 124 Query: 503 TLVREEVIDFSKPFMSLGISIMIK 526 R +V+DF+ PF S + IM++ Sbjct: 125 NSARSQVVDFTSPFFSTSLGIMVR 148 Score = 46.6 bits (109), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 34/130 (26%), Positives = 60/130 (46%), Gaps = 11/130 (8%) Query: 668 YGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKY-AYLLE 726 +GT+ S + + + A F +M +MR TT GVA + K A++++ Sbjct: 171 FGTVWESSAEAYIK----ASFPEMHAHMRRHS----APTTPHGVAMLTSDPPKLNAFIMD 222 Query: 727 STMNEY-IEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKN 785 ++ +Y + C + VG +GYGI P+ S L + ++ + + G +D L + Sbjct: 223 KSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHD 282 Query: 786 KWWYDKGECG 795 K WY CG Sbjct: 283 K-WYKMVPCG 291 >5H8N-A nrPDB Length = 285 Score = 80.9 bits (198), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 47/135 (34%), Positives = 80/135 (59%), Gaps = 6/135 (4%) Query: 396 VVTLTELP--SGNDTSGLENKTVVVTTILESPYVMMKKN-HEMLEGNERYEGYCVDLAAE 452 +VTL E P D L +T V T+ +V + + +E + + +G+C+D+ + Sbjct: 10 IVTLEEAPFVIVEDIDPL-TETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKK 68 Query: 453 IAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDF 512 +++ F Y L +V +GK+G + + +WNGM+GE+VY +A +A+ LTI R EV+DF Sbjct: 69 LSRTVKFTYDLYLVTNGKHGKKVNN--VWNGMIGEVVYQRAVMAVGSLTINEERSEVVDF 126 Query: 513 SKPFMSLGISIMIKK 527 S PF+ GIS+M+ + Sbjct: 127 SVPFVETGISVMVSR 141 Score = 36.2 bits (82), Expect = 0.065, Method: Compositional matrix adjust. Identities = 31/123 (25%), Positives = 58/123 (47%), Gaps = 12/123 (9%) Query: 668 YGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLES 727 +GT+ +GST+ R + + M YM + F + E K+ A++ ++ Sbjct: 165 FGTVPNGSTERNIRNN----YPYMHQYM-----TKFNQKGVEDALVSLKTGKLDAFIYDA 215 Query: 728 TMNEYIEQR-KPCDTMKVGGN--LDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLK 784 + Y R + C + +G + GYGIA KGS + ++LA+L+ G +++L+ Sbjct: 216 AVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELE 275 Query: 785 NKW 787 W Sbjct: 276 TLW 278 >2RC9-A nrPDB Length = 294 Score = 78.2 bits (191), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 35/83 (42%), Positives = 53/83 (63%), Gaps = 2/83 (2%) Query: 444 GYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTIT 503 GYC+DL ++A+ F + L IVGDGKYGA W G+VG+L+ G A++A+ +I Sbjct: 70 GYCIDLLEQLAEDMNFDFDLYIVGDGKYGA--WKNGHWTGLVGDLLSGTANMAVTSFSIN 127 Query: 504 LVREEVIDFSKPFMSLGISIMIK 526 R +VIDF+ PF S + I+++ Sbjct: 128 TARSQVIDFTSPFFSTSLGILVR 150 Score = 51.2 bits (121), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 32/123 (26%), Positives = 59/123 (47%), Gaps = 10/123 (8%) Query: 668 YGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKY-AYLLE 726 +GT+ S +++ R+S F +M YMR V T +GV ++ K A++++ Sbjct: 173 FGTVRESSAEDYVRQS----FPEMHEYMRRYN----VPATPDGVQYLKNDPEKLDAFIMD 224 Query: 727 STMNEY-IEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKN 785 + +Y + C + VG +GYGI P S L + ++ + + G +D L + Sbjct: 225 KALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHD 284 Query: 786 KWW 788 KW+ Sbjct: 285 KWY 287 >4YKP-A nrPDB Length = 256 Score = 69.3 bits (168), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 39/138 (28%), Positives = 68/138 (49%), Gaps = 2/138 (1%) Query: 408 TSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVG 467 + L + + + ++ E P++ E EGN+ + G D+ ++++ GF Y+ Sbjct: 2 SKNLIGRHLRLGSVEEQPFMFFAT--EGCEGNDCWSGMVNDMVVKLSEDLGFTYEYIQPD 59 Query: 468 DGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKK 527 D K+GA + T WNGM+ +L+ K D+ L+ R+ ID+S PFM GI ++K Sbjct: 60 DRKFGALNKTTNEWNGMIRDLLDDKTDMIAIDLSTNSARKSAIDYSFPFMDAGIKAVVKG 119 Query: 528 PQKSKPGVFSFLDPLAYE 545 + V LD Y+ Sbjct: 120 EGTTLNQVLELLDQDKYK 137 Score = 37.7 bits (86), Expect = 0.022, Method: Compositional matrix adjust. Identities = 17/49 (34%), Positives = 24/49 (48%) Query: 739 CDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKW 787 CD VG S Y PK S ++ ++ +LK E+G +D L KW Sbjct: 200 CDVFSVGEEFQSFEYAFGLPKDSPYKSLIDSHLLKFREEGFIDILWEKW 248 >5TUJ-C nrPDB Length = 235 Score = 59.3 bits (142), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 33/104 (31%), Positives = 54/104 (51%), Gaps = 13/104 (12%) Query: 437 EGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIA 496 + N +Y G+ +DLA +AK G K + W+G++ L GK DI Sbjct: 29 DKNGQYTGFDIDLAKALAKELGVKVEFVPT-------------TWDGIIPALQTGKFDIV 75 Query: 497 IAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLD 540 ++ +TIT R++ +DFS P+M+ G +I++KK K F L+ Sbjct: 76 MSGMTITPERKKKVDFSDPYMTAGQTILVKKDNADKIKSFEDLN 119 Score = 32.0 bits (71), Expect = 1.3, Method: Compositional matrix adjust. Identities = 36/140 (25%), Positives = 57/140 (40%), Gaps = 22/140 (15%) Query: 654 IESAEDLSK---QTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEG 710 I+S EDL+K + + GT + KEF ++KI F+ AE Sbjct: 112 IKSFEDLNKPDVKVAVQLGTTSEQAAKEFLPKAKIRTFE----------------NNAEA 155 Query: 711 VARVRKSKGKYAYLLESTMNEYIEQRKP-CDTMKVGGNLDSKGYGIATPKGSS-LRNAVN 768 V + A + +S + Y ++ P + V + G A KG L N VN Sbjct: 156 FQEVVSGRAD-AMVTDSPVAAYYAKKNPGLAVVVVDEPFTHEPLGFAIRKGDPELLNWVN 214 Query: 769 LAVLKLNEQGLLDKLKNKWW 788 + ++ + G DKL KW+ Sbjct: 215 NWLKQMKKDGTYDKLYEKWF 234 >4ZDM-A nrPDB Length = 261 Score = 53.1 bits (126), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 25/85 (29%), Positives = 46/85 (54%) Query: 442 YEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLT 501 Y G V++ + +++ F Y D K+G +++ T WNG++ +L+ K D+ + L+ Sbjct: 37 YTGVNVEIVSMMSQDLNFTYNFITPEDLKFGGKNSTTGEWNGLIRDLLDNKTDMIVVALS 96 Query: 502 ITLVREEVIDFSKPFMSLGISIMIK 526 VR+ IDFS M G+ ++K Sbjct: 97 NNAVRKADIDFSLSMMDGGLGALVK 121 Score = 38.5 bits (88), Expect = 0.013, Method: Compositional matrix adjust. Identities = 33/133 (24%), Positives = 61/133 (45%), Gaps = 9/133 (6%) Query: 659 DLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSK 718 +L Q + +G +DS + + ++ A Y R AE +V V + EG+ R+R Sbjct: 132 ELLNQDKYQWGVVDSRNPELLLASNQNA------DYNRIAEDAVKVGSYGEGLERMRA-- 183 Query: 719 GKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQG 778 G + ++ E Y + + CD +++G K S +N V+ +L + EQG Sbjct: 184 GGFVFIDEIPGINYATKGE-CDIVQIGETFQPFELAFGLRKNSPFKNLVDTFMLGIREQG 242 Query: 779 LLDKLKNKWWYDK 791 ++ +L K+ K Sbjct: 243 VISELYAKYENQK 255 >4PSH-A nrPDB Length = 227 Score = 51.6 bits (122), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 30/106 (28%), Positives = 53/106 (50%), Gaps = 13/106 (12%) Query: 434 EMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKA 493 E ++ N G+ VDLA EIA+ G + K+ ++G++ L+ K Sbjct: 23 EFVDENGNIVGFDVDLAKEIARRLGVELKIV-------------DMTFDGLIPSLLTKKI 69 Query: 494 DIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFL 539 D+ I+ +TIT R++V+ FS P+ G I+++K +P + L Sbjct: 70 DVIISGMTITEERKKVVAFSDPYFDAGQVIVVRKDSDFRPKTYEDL 115 >4ZV2-A nrPDB Length = 233 Score = 50.4 bits (119), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 30/93 (32%), Positives = 48/93 (51%), Gaps = 13/93 (13%) Query: 439 NERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIA 498 N + G+ +DLA IAK G K + + ++G++ L GK D+ IA Sbjct: 29 NGKLVGFDIDLAKAIAKKLGVKVEFKPMD-------------FDGIIPALQSGKIDVVIA 75 Query: 499 PLTITLVREEVIDFSKPFMSLGISIMIKKPQKS 531 +TIT R++ +DFS P+ G +I++KK S Sbjct: 76 GMTITEERKKQVDFSDPYFEAGQAIVVKKGNDS 108 Score = 33.5 bits (75), Expect = 0.38, Method: Compositional matrix adjust. Identities = 19/58 (32%), Positives = 30/58 (51%), Gaps = 1/58 (1%) Query: 732 YIEQRKPCDTMKVGGNLDSKGYGIATPKGSS-LRNAVNLAVLKLNEQGLLDKLKNKWW 788 Y++Q VG + YGIA KG+S L +N A+ ++ + G DK+ KW+ Sbjct: 174 YVKQNPNAGVKIVGETFSGEPYGIAVRKGNSELLEKINKALEEMKKDGTYDKIYEKWF 231 >3K4U-A nrPDB Length = 245 Score = 49.3 bits (116), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 29/84 (34%), Positives = 46/84 (54%), Gaps = 13/84 (15%) Query: 444 GYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTIT 503 G+ VDLA E+AK G K KL W+G++ LV K DI I+ +TI+ Sbjct: 29 GFDVDLAREMAKAMGVKLKLVPTS-------------WDGLIPGLVTEKFDIIISGMTIS 75 Query: 504 LVREEVIDFSKPFMSLGISIMIKK 527 R ++F +P++ +G S+++KK Sbjct: 76 QERNLRVNFVEPYIVVGQSLLVKK 99 >4F3S-A nrPDB Length = 255 Score = 48.5 bits (114), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 35/110 (31%), Positives = 57/110 (51%), Gaps = 23/110 (20%) Query: 409 SGLENKTVVVTTILESPYVMMKKNHEMLEGN--ERYEGYCVDLAAEIAKHCGFKYKLTIV 466 S +E +T+ V SP ++ K L+G E + YC ++HC KL I Sbjct: 4 SIVEGRTLNVAVSPASPPMLFKSADGKLQGIDLELFSSYCQ------SRHC----KLNIT 53 Query: 467 GDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPF 516 +Y W+GM+G + G+AD+A + ++IT R++VIDFS+P+ Sbjct: 54 ---EYA--------WDGMLGAVASGQADVAFSGISITDKRKKVIDFSEPY 92 >5JOS-A nrPDB Length = 247 Score = 47.0 bits (110), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 25/92 (27%), Positives = 45/92 (48%), Gaps = 13/92 (14%) Query: 441 RYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPL 500 +Y G+ +D+A +AK G K + W ++ +L K DIA+ + Sbjct: 44 QYTGFDIDVAKSLAKSLGVKVEFVPT-------------TWPTLMSDLQADKFDIAMGGV 90 Query: 501 TITLVREEVIDFSKPFMSLGISIMIKKPQKSK 532 T+T R++ DFS P+M+ G + +++K K Sbjct: 91 TVTPERQKKADFSDPYMTFGKTPLVRKEDADK 122 Score = 30.0 bits (66), Expect = 4.6, Method: Compositional matrix adjust. Identities = 31/141 (21%), Positives = 59/141 (41%), Gaps = 26/141 (18%) Query: 654 IESAEDLSK---QTEIAYGTLDSGSTKEFFRRSKIAVFD---KMWTYMRSAEPSVFVRTT 707 +S ED+++ + + G + +E +++KI V++ +++ + S V + T Sbjct: 123 FKSLEDINRPDVRVAVNPGGTNEKFAREHLKKAKITVYENNVEIFQEVASGRADVMITDT 182 Query: 708 AEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSS-LRNA 766 E + +K G A L++ KGY + PKG N Sbjct: 183 VEALYYAKKHPGLAAVLVDKPFTH-----------------SEKGYMM--PKGDQEFLNY 223 Query: 767 VNLAVLKLNEQGLLDKLKNKW 787 VN + ++ +QG +KL KW Sbjct: 224 VNQWLDQMKQQGTYEKLYEKW 244 >4F3P-A nrPDB Length = 249 Score = 47.0 bits (110), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 26/87 (29%), Positives = 46/87 (52%), Gaps = 13/87 (14%) Query: 440 ERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAP 499 ++Y G+ +DL AEIAK G+ YK+ + + G++ L D+A++ Sbjct: 43 DKYVGFDLDLWAEIAKGAGWTYKIQPMD-------------FAGLIPALQTQNIDVALSG 89 Query: 500 LTITLVREEVIDFSKPFMSLGISIMIK 526 +TI R + IDFS P+ G++ M++ Sbjct: 90 MTIKEERRKAIDFSDPYYDSGLAAMVQ 116 Score = 30.8 bits (68), Expect = 2.8, Method: Compositional matrix adjust. Identities = 15/45 (33%), Positives = 21/45 (46%) Query: 744 VGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWW 788 G + YGI PKGS L VN + ++ G K+ KW+ Sbjct: 197 AGAPVSGDKYGIGFPKGSPLVAKVNAELARMKADGRYAKIYKKWF 241 >4IO3-A nrPDB Length = 248 Score = 45.1 bits (105), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 22/61 (36%), Positives = 32/61 (52%) Query: 731 EYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYD 790 EY+ C+ VG + D +GI TPK +++ +L L E G+LD LK KW+ Sbjct: 185 EYVTNNIYCNLTLVGEDFDKSTFGIVTPKEWLYAKDLDVNILSLRETGILDNLKKKWFQT 244 Query: 791 K 791 K Sbjct: 245 K 245 Score = 35.8 bits (81), Expect = 0.090, Method: Compositional matrix adjust. Identities = 24/87 (27%), Positives = 39/87 (44%), Gaps = 9/87 (10%) Query: 441 RYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPL 500 + GY +DL + GF V D + + + G+V L G DIAI + Sbjct: 36 KLTGYVLDLIEYLRDKMGF------VADVQLAPPNTS---YTGLVLALANGDYDIAIGDI 86 Query: 501 TITLVREEVIDFSKPFMSLGISIMIKK 527 T+T R E++ FS + I+++K Sbjct: 87 TVTSARREIVAFSNSISDNSMRILMRK 113 >4H5F-A nrPDB Length = 243 Score = 43.9 bits (102), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 31/114 (27%), Positives = 55/114 (48%), Gaps = 17/114 (14%) Query: 414 KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGA 473 K VV T+ +P+ +++G + G +D+A IA G K ++ + Sbjct: 13 KLVVATSPDYAPFEF----QSLVDGKNQVVGADIDMAQAIADELGVKLEILSMS------ 62 Query: 474 RDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKK 527 ++ ++ L GKAD+A+A ++ T R+EV DFS P+ IS ++ K Sbjct: 63 -------FDNVLTSLQTGKADLAVAGISATDERKEVFDFSIPYYENKISFLVHK 109 >1GGG-A nrPDB Length = 226 Score = 42.7 bits (99), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 34/115 (29%), Positives = 54/115 (46%), Gaps = 21/115 (18%) Query: 412 ENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKY 471 + K VV T P+ E +G + Y G+ VDL A IAK Y+L + Sbjct: 2 DKKLVVATDTAFVPF-------EFKQG-DLYVGFDVDLWAAIAKELKLDYELKPMD---- 49 Query: 472 GARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIK 526 ++G++ L D+A+A +TIT R++ IDFS + G+ +M+K Sbjct: 50 ---------FSGIIPALQTKNVDLALAGITITDERKKAIDFSDGYYKSGLLVMVK 95 Score = 40.0 bits (92), Expect = 0.005, Method: Compositional matrix adjust. Identities = 21/46 (45%), Positives = 31/46 (67%), Gaps = 1/46 (2%) Query: 744 VGGNLDSKGYGIATPKGSS-LRNAVNLAVLKLNEQGLLDKLKNKWW 788 VG +L+++ YGIA PKGS LR+ VN A+ L E G +++ KW+ Sbjct: 176 VGDSLEAQQYGIAFPKGSDELRDKVNGALKTLRENGTYNEIYKKWF 221 >4G4P-A nrPDB Length = 244 Score = 42.4 bits (98), Expect = 0.001, Method: Compositional matrix adjust. Identities = 42/171 (24%), Positives = 70/171 (40%), Gaps = 29/171 (16%) Query: 410 GLENKTVVVTTILE-SPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGD 468 G+E K + T L +P+ E + +Y G VDL IAK F+ L +G Sbjct: 19 GMEGKKYTIGTDLTFAPF-------EFQDSKGKYIGIDVDLLDAIAKDQDFEVDLKPLG- 70 Query: 469 GKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKP 528 ++ V + + D IA ++IT R++ DFS P+ G+ + +KK Sbjct: 71 ------------FDSAVQAIQSKQIDGMIAGMSITDERKKSFDFSDPYFDSGLQLAVKKG 118 Query: 529 QKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFED 579 + S+ D + V A +G FL Y++ + F+D Sbjct: 119 NDK---IKSYDD-----LKGKTVAAKVGTESANFLEKNKEKYDYTIKNFDD 161 >4KQP-A nrPDB Length = 232 Score = 42.0 bits (97), Expect = 0.001, Method: Compositional matrix adjust. Identities = 25/90 (27%), Positives = 43/90 (47%), Gaps = 13/90 (14%) Query: 434 EMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKA 493 E ++++ G VDL IAK+ GFK K +G + V + G A Sbjct: 22 EFQNDDKQFTGIDVDLLNAIAKNQGFKLKWNFIG-------------FQAAVDSVQSGHA 68 Query: 494 DIAIAPLTITLVREEVIDFSKPFMSLGISI 523 D ++ ++IT R++V D+ P+ S ++I Sbjct: 69 DGMMSGMSITDARKQVFDYGSPYYSSNLTI 98 >6FXG-A nrPDB Length = 227 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 27/97 (27%), Positives = 46/97 (47%), Gaps = 13/97 (13%) Query: 434 EMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKA 493 E G +++ G VD+ E+AK +K +++ G ++ + L G+ Sbjct: 18 EFQNGQKKWVGIDVDIMQEVAKINDWKLEMSYPG-------------FDAALQNLKAGQV 64 Query: 494 DIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQK 530 D IA +TIT R+E DFS P+ + ++I K K Sbjct: 65 DGIIAGMTITDERKETFDFSNPYYTSALTIATTKDSK 101 >2Q2A-A nrPDB Length = 272 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 30/116 (25%), Positives = 51/116 (43%), Gaps = 21/116 (18%) Query: 412 ENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKY 471 + K VV T +P+ M+K + G+ VDL + K G Y+L +G Sbjct: 41 KKKVVVGTDAAFAPFEYMQKG--------KIVGFDVDLLDAVMKAAGLDYELKNIG---- 88 Query: 472 GARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKK 527 W+ + L + D+ I+ +TIT R++ DFS P+ I++K+ Sbjct: 89 ---------WDPLFASLQSKEVDMGISGITITDERKQSYDFSDPYFEATQVILVKQ 135 >4KPT-A nrPDB Length = 251 Score = 40.4 bits (93), Expect = 0.003, Method: Compositional matrix adjust. Identities = 27/97 (27%), Positives = 46/97 (47%), Gaps = 13/97 (13%) Query: 434 EMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKA 493 E G +++ G VD+ E+AK +K +++ G ++ + L G+ Sbjct: 42 EFQNGQKKWVGIDVDIMQEVAKINDWKLEMSYPG-------------FDAALQNLKAGQV 88 Query: 494 DIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQK 530 D IA +TIT R+E DFS P+ + ++I K K Sbjct: 89 DGIIAGMTITDERKETFDFSNPYYTSALTIATTKDSK 125 >4ZEF-A nrPDB Length = 251 Score = 40.4 bits (93), Expect = 0.003, Method: Compositional matrix adjust. Identities = 27/86 (31%), Positives = 40/86 (46%), Gaps = 13/86 (15%) Query: 442 YEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLT 501 Y G VDL A+ GF + +G ++ V + G+AD +A +T Sbjct: 50 YVGIDVDLVKRAAELQGFTVEFKFIG-------------FSSAVQAVESGQADGMVAGMT 96 Query: 502 ITLVREEVIDFSKPFMSLGISIMIKK 527 IT R++ DFS P+ GI I +KK Sbjct: 97 ITDDRKKAFDFSVPYFDSGIQIAVKK 122 >4MS4-A nrPDB Length = 420 Score = 39.7 bits (91), Expect = 0.006, Method: Compositional matrix adjust. Identities = 22/63 (34%), Positives = 36/63 (57%), Gaps = 10/63 (15%) Query: 343 EIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGY---------WSEVD 393 +I RA+ EG+SG++ FD +G R+ +T+ I +L+ +KIGY WS+ D Sbjct: 344 QIYRAMNSSSFEGVSGHVVFDASGSRMAWTL-IEQLQGGSYKKIGYYDSTKDDLSWSKTD 402 Query: 394 KMV 396 K + Sbjct: 403 KWI 405 >4YMX-A nrPDB Length = 260 Score = 39.3 bits (90), Expect = 0.007, Method: Compositional matrix adjust. Identities = 24/81 (29%), Positives = 42/81 (51%), Gaps = 13/81 (16%) Query: 433 HEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGK 492 H++ G + G+ +D+A IAK G K ++ +D D + G++ L G+ Sbjct: 53 HKVEGGKDEIVGFDIDIANAIAKKLGVKLEI----------KDMD---FKGLIPALQAGR 99 Query: 493 ADIAIAPLTITLVREEVIDFS 513 D+ IA +T T R++ +DFS Sbjct: 100 VDMVIAGMTPTAERKKSVDFS 120 Score = 29.3 bits (64), Expect = 7.1, Method: Compositional matrix adjust. Identities = 15/38 (39%), Positives = 23/38 (60%), Gaps = 1/38 (2%) Query: 752 GYGIATPKGS-SLRNAVNLAVLKLNEQGLLDKLKNKWW 788 G +A KG+ SL + VN + +L + G DKL +KW+ Sbjct: 221 GSAVAVAKGNKSLLDVVNEVIKELKQSGEYDKLVDKWF 258 >2IEE-A nrPDB Length = 271 Score = 38.9 bits (89), Expect = 0.010, Method: Compositional matrix adjust. Identities = 27/95 (28%), Positives = 44/95 (46%), Gaps = 14/95 (14%) Query: 433 HEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGK 492 H+ G+++ GY V++ E AK G K + +G +GM+ + G+ Sbjct: 37 HDTDSGSDKLTGYEVEVVREAAKRLGLKVEFKEMG-------------IDGMLTAVNSGQ 83 Query: 493 ADIAIAPLTITLVREEVIDFSKPFM-SLGISIMIK 526 D A + +T REE FS P+ S G +I+ K Sbjct: 84 VDAAANDIDVTKDREEKFAFSTPYKYSYGTAIVRK 118 >4I62-A nrPDB Length = 269 Score = 38.9 bits (89), Expect = 0.010, Method: Compositional matrix adjust. Identities = 32/129 (24%), Positives = 62/129 (48%), Gaps = 22/129 (17%) Query: 404 SGNDTSGLE-----NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCG 458 S N ++G+E K VV +P+ K +++G + G ++LA IA G Sbjct: 25 SNNQSAGIEAIKSKGKLVVALNPDFAPFEYQK----VVDGKNQIVGSDIELAKAIATELG 80 Query: 459 FKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMS 518 + +L+ + ++ ++ + GKAD+AI+ ++ T R +V DFS P+ + Sbjct: 81 VELELSPMS-------------FDNVLASVQSGKADLAISGVSKTDERSKVFDFSTPYYT 127 Query: 519 LGISIMIKK 527 +++KK Sbjct: 128 AKNKLIVKK 136 >2PYY-A nrPDB Length = 228 Score = 38.1 bits (87), Expect = 0.015, Method: Compositional matrix adjust. Identities = 28/113 (24%), Positives = 51/113 (45%), Gaps = 20/113 (17%) Query: 414 KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGA 473 + ++V T + P+V+ K G+ +DL IA G + KL +Y + Sbjct: 3 QPLLVATRVIPPFVLSNKGE--------LSGFSIDLWRSIATQIGIESKLI-----EYSS 49 Query: 474 RDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIK 526 ++ + K ++ IA ++IT RE+ DFS P + G+ IM++ Sbjct: 50 VPE-------LISAIKDNKVNLGIAAISITAEREQNFDFSLPIFASGLQIMVR 95 Score = 37.7 bits (86), Expect = 0.020, Method: Compositional matrix adjust. Identities = 19/48 (39%), Positives = 24/48 (50%) Query: 744 VGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDK 791 VG L + YGI P S R +N A+L L E G L +KW+ K Sbjct: 177 VGSILREESYGIILPNNSPYRKPINQALLNLKENGTYQSLYDKWFDPK 224 >5OTA-A nrPDB Length = 265 Score = 37.4 bits (85), Expect = 0.032, Method: Compositional matrix adjust. Identities = 19/74 (25%), Positives = 35/74 (47%), Gaps = 13/74 (17%) Query: 444 GYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTIT 503 G+ +DL ++ K + K + W+G++ L G+ D +A + I Sbjct: 29 GFDIDLGNDLCKRMNIECKFV-------------EQAWDGIIPSLTAGRYDAIMAAMGIQ 75 Query: 504 LVREEVIDFSKPFM 517 RE+VI FS+P++ Sbjct: 76 PAREKVIAFSRPYL 89 >3HDI-A nrPDB Length = 421 Score = 36.2 bits (82), Expect = 0.065, Method: Compositional matrix adjust. Identities = 45/176 (25%), Positives = 64/176 (36%), Gaps = 57/176 (32%) Query: 189 DEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVI-------TIGKHVKGY-------- 233 D + S FQ EL+KER+V+ + E V+D D ++ T GKH GY Sbjct: 104 DMFFHSTFQKEELEKERKVVFE-EIKMVDDTPDDIVHDLLSSATYGKHSLGYPILGTVET 162 Query: 234 ----------HYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEK 283 HY+ F GD + I G + D L+ K E +S ++ Sbjct: 163 LNSFNEGMLRHYMDR---FYTGDYVVISVAG---------NVHDELIDKIKETFSQVKPT 210 Query: 284 EYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWG 339 Y Y + M R +RK+ E A CL P +P G Sbjct: 211 TY--------------NYQGEKPMFLPNRIVRKKETE-----QAHLCLGYPGLPIG 247 >4OEN-A nrPDB Length = 223 Score = 35.0 bits (79), Expect = 0.14, Method: Compositional matrix adjust. Identities = 34/149 (22%), Positives = 62/149 (41%), Gaps = 22/149 (14%) Query: 441 RYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPL 500 +Y G ++L IAK GF+ ++T G ++ + + G+AD IA + Sbjct: 24 QYTGIDMELIKAIAKDQGFEIEITNPG-------------FDAAISAVQAGQADGIIAGM 70 Query: 501 TITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVV 560 ++T R+ DFS+ + + + +K+ + S+ D + V G + Sbjct: 71 SVTDARKATFDFSESYYTANTILGVKESSN----IASYED-----LKGKTVGVKNGTASQ 121 Query: 561 LFLVSRFSPYEWHTEEFEDGRETQSSEST 589 FL S Y + + F DG S +T Sbjct: 122 TFLTENQSKYGYKIKTFADGSSMYDSLNT 150 >5ORE-A nrPDB Length = 263 Score = 34.7 bits (78), Expect = 0.18, Method: Compositional matrix adjust. Identities = 26/97 (26%), Positives = 46/97 (47%), Gaps = 15/97 (15%) Query: 441 RYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPL 500 + +G+ +DLA + + K K IV + W+G++ L K D +A + Sbjct: 25 KLDGFEIDLANALCEK--MKAKCQIV-----------AQNWDGIMPSLTGKKYDAIMAAM 71 Query: 501 TITLVREEVIDFSKPFMSL--GISIMIKKPQKSKPGV 535 ++T R+EVI FS P+ + G ++M PG+ Sbjct: 72 SVTPKRQEVIGFSIPYAAGINGFAVMGDSKLAEMPGL 108 >5EYF-A nrPDB Length = 245 Score = 34.3 bits (77), Expect = 0.24, Method: Compositional matrix adjust. Identities = 19/51 (37%), Positives = 30/51 (58%), Gaps = 1/51 (1%) Query: 744 VGGNLDSKGYGIATPKGS-SLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGE 793 VGG ++ YGIA KG + AVN A+ +++ G DK+ KW+ ++ E Sbjct: 191 VGGTFTNEPYGIAINKGQENFLKAVNQALEEMHADGTYDKIYQKWFPNETE 241 Score = 33.1 bits (74), Expect = 0.60, Method: Compositional matrix adjust. Identities = 28/91 (30%), Positives = 45/91 (49%), Gaps = 12/91 (13%) Query: 443 EGYCVDLAAEIAKHCGFKYKLTIVGD-GKYGARDADTKIWNGMVGELVYGKADIAIAPLT 501 +G+ VD+A I K I+GD GK + +K + L G D IA +T Sbjct: 39 QGFDVDIAKAITKK--------ILGDNGKTEFVEVTSKT---RIPLLKNGNIDAIIATMT 87 Query: 502 ITLVREEVIDFSKPFMSLGISIMIKKPQKSK 532 IT R++ +DFS + G ++++KK + K Sbjct: 88 ITDERKKQVDFSDVYFDAGQALLVKKGSQIK 118 >3I6V-A nrPDB Length = 232 Score = 34.3 bits (77), Expect = 0.24, Method: Compositional matrix adjust. Identities = 15/37 (40%), Positives = 25/37 (67%) Query: 481 WNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFM 517 W+ ++ LV G D IA ++IT R+EVIDF++ ++ Sbjct: 53 WDSIIPNLVSGNYDTIIAGMSITDERDEVIDFTQNYI 89 >3VV5-A nrPDB Length = 260 Score = 33.9 bits (76), Expect = 0.32, Method: Compositional matrix adjust. Identities = 20/65 (30%), Positives = 38/65 (58%), Gaps = 1/65 (1%) Query: 731 EYIEQRKPCDTMKVGGNLDSKGYGIATPKGS-SLRNAVNLAVLKLNEQGLLDKLKNKWWY 789 E I++RK +T++VG + + +A KG+ SL +A+N A+ +L + G ++ KW+ Sbjct: 195 EAIKERKLENTLQVGELVFQERVAMAVAKGNKSLLDALNRALAELMQDGTYARISQKWFG 254 Query: 790 DKGEC 794 + C Sbjct: 255 EDVRC 259 >3TQL-A nrPDB Length = 227 Score = 33.5 bits (75), Expect = 0.38, Method: Compositional matrix adjust. Identities = 23/103 (22%), Positives = 43/103 (41%), Gaps = 20/103 (19%) Query: 425 PYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGM 484 PYV M + ++ EG+ D+ + K + TI + W+ + Sbjct: 14 PYVYMGPSGQV-------EGFGADIVKAVCKQ--MQAVCTI-----------SNQPWDSL 53 Query: 485 VGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKK 527 + L GK D + IT R++ +DF+ P+ + +S + K Sbjct: 54 IPSLKLGKFDALFGGMNITTARQKEVDFTDPYYTNSVSFIADK 96 >2HYI-C nrPDB Length = 413 Score = 33.1 bits (74), Expect = 0.54, Method: Compositional matrix adjust. Identities = 17/83 (20%), Positives = 40/83 (48%), Gaps = 4/83 (4%) Query: 508 EVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW----MCIVFAYIGVSVVLFL 563 E+++ + FM+ I I++K+ + + G+ F + E W +C ++ + ++ + Sbjct: 224 EILEMTNKFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIF 283 Query: 564 VSRFSPYEWHTEEFEDGRETQSS 586 + +W TE+ + T SS Sbjct: 284 CNTKRKVDWLTEKMREANFTVSS 306 >5HPQ-A nrPDB Length = 255 Score = 33.1 bits (74), Expect = 0.57, Method: Compositional matrix adjust. Identities = 27/109 (24%), Positives = 51/109 (46%), Gaps = 22/109 (20%) Query: 442 YEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLT 501 Y G+ VD+A +A+ G KL +V W ++ + + DIA++ ++ Sbjct: 45 YAGFDVDMAQRLAESLG--AKLVVVPTS-----------WPNLMRDFADDRFDIAMSGIS 91 Query: 502 ITLVREEVIDFSKPFMSLG---ISIMIKKP------QKSKPGVFSFLDP 541 I L R+ FS P++ G I++ ++ Q +PGV + ++P Sbjct: 92 INLERQRQAYFSIPYLRDGKTPITLCSEEARFQTLEQIDQPGVTAIVNP 140 >5LOM-A nrPDB Length = 269 Score = 32.3 bits (72), Expect = 0.88, Method: Compositional matrix adjust. Identities = 25/115 (21%), Positives = 55/115 (47%), Gaps = 18/115 (15%) Query: 411 LENKTVVVTTILES-PYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDG 469 ++ T+ V T+ ++ PY +GN + G+ ++L +A GFK + + Sbjct: 28 IDPTTISVGTMGDAKPYAFTTA-----DGN--FTGFDIELFLNVAGRLGFKKEQVVFTGQ 80 Query: 470 KYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIM 524 ++ A ++ + G+ D+A A + T R+E +DFS +++ +S++ Sbjct: 81 EFSA----------LMPSVANGRFDVAAAAIGTTAKRKETVDFSDGYLAGFLSVL 125 >4YND-A nrPDB Length = 461 Score = 32.3 bits (72), Expect = 0.98, Method: Compositional matrix adjust. Identities = 13/32 (40%), Positives = 18/32 (56%) Query: 233 YHYIIANLGFTDGDLLKIQFGGANVSGFQIVD 264 +H+ +LGF D D L + F N +GF I D Sbjct: 185 HHFYSKHLGFPDNDSLVVLFAQVNCNGFTIED 216 >3EIQ-A nrPDB Length = 414 Score = 32.0 bits (71), Expect = 1.3, Method: Compositional matrix adjust. Identities = 16/74 (21%), Positives = 37/74 (50%), Gaps = 4/74 (5%) Query: 508 EVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW----MCIVFAYIGVSVVLFL 563 +V++ +K FM I I++KK + + G+ F + E W +C ++ + ++ + Sbjct: 227 DVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIF 286 Query: 564 VSRFSPYEWHTEEF 577 ++ +W TE+ Sbjct: 287 INTRRKVDWLTEKM 300 >2Y7I-A nrPDB Length = 229 Score = 31.6 bits (70), Expect = 1.6, Method: Compositional matrix adjust. Identities = 19/93 (20%), Positives = 44/93 (47%), Gaps = 14/93 (15%) Query: 433 HEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGK 492 +E ++ + + G+ +D+A + K + T + ++ ++ L + K Sbjct: 19 YEFVDADNKIVGFDIDVANAVCKEMQAECSFT-------------NQSFDSLIPSLRFKK 65 Query: 493 ADIAIAPLTITLVREEVIDFSKPFMSLGISIMI 525 D IA + +T RE+ + FS+P+ G+S ++ Sbjct: 66 FDAVIAGMDMTPKREQQVSFSQPYYE-GLSAVV 97 >5VXG-A nrPDB Length = 358 Score = 30.4 bits (67), Expect = 3.5, Method: Compositional matrix adjust. Identities = 18/54 (33%), Positives = 29/54 (53%), Gaps = 2/54 (3%) Query: 632 IIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKI 685 +++ TANL T+ERM SP + E+ + E+A TL G+ RS++ Sbjct: 166 LVVDGETANLVYEKTLERMTSPDVTEEEF--RNELAALTLGCGAAAMVMARSEL 217 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5IDF-B nrPDB 1184 0.0 4U1Y-A nrPDB 1167 0.0 6QKC-A nrPDB 1131 0.0 5KUF-A nrPDB 995 0.0 5IPR-B nrPDB 735 0.0 4PE5-B nrPDB 735 0.0 6IRA-D nrPDB 703 0.0 5UP2-B nrPDB 695 0.0 5KUH-A nrPDB 612 e-175 5UOW-A nrPDB 593 e-169 5FXI-A nrPDB 593 e-169 5L2E-A nrPDB 503 e-142 5UN1-B nrPDB 466 e-131 5UN1-G nrPDB 466 e-131 5O9A-A nrPDB 229 4e-60 3FAT-A nrPDB 228 8e-60 1YAE-A nrPDB 226 2e-59 3DP4-A nrPDB 226 2e-59 2XXT-A nrPDB 213 2e-55 4MF3-A nrPDB 210 2e-54 5EHM-A nrPDB 203 3e-52 4IGR-A nrPDB 202 7e-52 5IKB-A nrPDB 200 2e-51 5DT6-A nrPDB 195 8e-50 5CC2-A nrPDB 172 6e-43 4WXJ-A nrPDB 171 2e-42 5I2K-B nrPDB 160 3e-39 4YKP-A nrPDB 153 2e-37 5H8N-A nrPDB 148 8e-36 2RC9-A nrPDB 148 1e-35 2RCB-A nrPDB 142 6e-34 3OEK-A nrPDB 133 3e-31 5TUJ-C nrPDB 129 5e-30 4G4P-A nrPDB 128 1e-29 4ZDM-A nrPDB 123 3e-28 4ZV2-A nrPDB 110 3e-24 4PSH-A nrPDB 108 1e-23 4F3P-A nrPDB 104 2e-22 5JOS-A nrPDB 102 9e-22 1GGG-A nrPDB 102 9e-22 3K4U-A nrPDB 101 2e-21 4H5F-A nrPDB 98 2e-20 4KQP-A nrPDB 94 3e-19 4IO3-A nrPDB 89 7e-18 4F3S-A nrPDB 83 5e-16 Sequences not found previously or not previously below threshold: 4ZEF-A nrPDB 106 5e-23 6FXG-A nrPDB 91 2e-18 4OEN-A nrPDB 90 3e-18 4KPT-A nrPDB 89 8e-18 4YMX-A nrPDB 86 4e-17 4I62-A nrPDB 86 6e-17 2Q2A-A nrPDB 84 3e-16 5HPQ-A nrPDB 69 7e-12 2PYY-A nrPDB 68 2e-11 5EYF-A nrPDB 65 1e-10 2Y7I-A nrPDB 63 4e-10 2IEE-A nrPDB 63 8e-10 5OTA-A nrPDB 61 2e-09 5LOM-A nrPDB 61 2e-09 3TQL-A nrPDB 61 2e-09 5OWF-A nrPDB 59 6e-09 3VV5-A nrPDB 59 6e-09 1HSL-A nrPDB 59 7e-09 3I6V-A nrPDB 58 1e-08 5ORE-A nrPDB 57 5e-08 5X2M-A nrPDB 56 6e-08 1IIT-A nrPDB 56 6e-08 4F11-A nrPDB 55 2e-07 1ISS-A nrPDB 54 2e-07 3DEL-B nrPDB 54 3e-07 4Q0C-A nrPDB 46 8e-05 1YK0-A nrPDB 41 0.003 2Q88-A nrPDB 40 0.005 3A3K-A nrPDB 37 0.026 1RHC-A nrPDB 37 0.029 2O1M-A nrPDB 36 0.11 3PNZ-A nrPDB 34 0.26 3CPX-A nrPDB 31 3.6 3DBM-A nrPDB 30 5.4 3QS1-A nrPDB 30 5.7 3ULE-B nrPDB 30 6.2 >5IDF-B nrPDB Length = 874 Score = 1184 bits (3063), Expect = 0.0, Method: Composition-based stats. Identities = 628/867 (72%), Positives = 747/867 (86%), Gaps = 12/867 (1%) Query: 25 NSIQIGGLFPRGADQEYSAFRVGMVQFSTS------EFRLTPHIDNLEVANSFAVTNAFC 78 N+I IGGLF R QE+SAFR + ++T+ F L H+D+L+ +NSF+VTNAFC Sbjct: 12 NTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFC 71 Query: 79 SQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLS 138 SQFSRGVYAIFGFYD+ S+NT+TSFCG LH SF+TPSFPTD FVIQMRP LKGA+LS Sbjct: 72 SQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADVQFVIQMRPALKGAILS 131 Query: 139 LIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQD 198 L+ YY+W+KF YLYD++RG S LQA++++A + WQVTA +VGNI K + +R + ++ Sbjct: 132 LLSYYKWEKFVYLYDTERGFSVLQAIMEAAVQNNWQVTARSVGNI---KDVQEFRRIIEE 188 Query: 199 LELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVS 258 ++ ++E+R ++DCE +++N I++QV+ +GKH +GYHY++ANLGFTD L ++ GGAN++ Sbjct: 189 MDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANIT 248 Query: 259 GFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQR 318 GFQIV+ ++ +V +FI+RW L+E E+P A +KYTSALT+DA+ V+ EAFR LR+QR Sbjct: 249 GFQIVNNENPMVQQFIQRWVRLDECEFPEAKNAPLKYTSALTHDAILVIAEAFRYLRRQR 308 Query: 319 IEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMEL 378 +++SRRG+AGDCLANPAVPW QG++IERALK VQV+G++GNI+FD G+R NYTI++ E+ Sbjct: 309 VDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEM 368 Query: 379 KTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEG 438 K +G RK GYW+E ++ V ++ ND+S EN+T+VVTTILESPYVM KKNHE LEG Sbjct: 369 KVSGSRKAGYWNEYERFV-PFSDQQISNDSSSSENRTIVVTTILESPYVMYKKNHEQLEG 427 Query: 439 NERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIA 498 NERYEGYCVDLA EIAKH G KYKL+IVGDGKYGARD +TKIWNGMVGELVYG+ADIA+A Sbjct: 428 NERYEGYCVDLAYEIAKHVGIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVA 487 Query: 499 PLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVS 558 PLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVS Sbjct: 488 PLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVS 547 Query: 559 VVLFLVSRFSPYEWHTE-EFEDGRETQSS-ESTNEFGIFNSLWFSLGAFMQQGCDISPRS 616 VVLFLVSRFSPYEWH E E+ R+ QS + NEFGIFNSLWFSLGAFMQQGCDISPRS Sbjct: 548 VVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRS 607 Query: 617 LSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGST 676 LSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL+KQTEIAYGTLDSGST Sbjct: 608 LSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGST 667 Query: 677 KEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR 736 KEFFRRSKIAV++KMW+YM+SAEPSVF +TTA+GVARVRKSKGK+A+LLESTMNEYIEQR Sbjct: 668 KEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQR 727 Query: 737 KPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGS 796 KPCDTMKVGGNLDSKGYG+ATPKGS+L VNLAVLKL+EQG+LDKLKNKWWYDKGECG+ Sbjct: 728 KPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGECGA 787 Query: 797 GGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKNAQNIN 856 SK+KTSALSLSNVAGVFYILVGGLGLAM+VALIEFCYKSRAE+KRMK+ KN QN Sbjct: 788 KDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTKNTQNFK 847 Query: 857 PSSSQNSQNFATYKEGYNVYGIESVKI 883 P+ + N+QN+ATY+EGYNVYG ESVKI Sbjct: 848 PAPATNTQNYATYREGYNVYGTESVKI 874 >4U1Y-A nrPDB Length = 819 Score = 1167 bits (3018), Expect = 0.0, Method: Composition-based stats. Identities = 787/823 (95%), Positives = 792/823 (96%), Gaps = 9/823 (1%) Query: 25 NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRG 84 NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRG Sbjct: 1 NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRG 60 Query: 85 VYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQ 144 VYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQ Sbjct: 61 VYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQ 120 Query: 145 WDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQDLELKKE 204 WDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDE YRSLFQDLELKKE Sbjct: 121 WDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYRSLFQDLELKKE 180 Query: 205 RRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVD 264 RRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGA VSGFQIVD Sbjct: 181 RRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGAEVSGFQIVD 240 Query: 265 YDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRR 324 YDDSLVSKFIERWSTLEEKEYPGAHT TIKYTSALTYDAVQVMTEAFRNLRKQRIEISRR Sbjct: 241 YDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRR 300 Query: 325 GNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPR 384 GNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPR Sbjct: 301 GNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPR 360 Query: 385 KIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEG 444 KIGYWSEVDKMVVTLTE +DTSGLE KTVVVTTILESPYVMMKKNHEMLEGNERYEG Sbjct: 361 KIGYWSEVDKMVVTLTE----DDTSGLEQKTVVVTTILESPYVMMKKNHEMLEGNERYEG 416 Query: 445 YCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITL 504 YCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITL Sbjct: 417 YCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITL 476 Query: 505 VREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLV 564 VREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWM IVFAYI VSVVLFLV Sbjct: 477 VREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMAIVFAYILVSVVLFLV 536 Query: 565 SRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGG 624 SRFSPYEWHTEEFEDG ESTNEFGIFNS WF+L F QQG DISPRSLS RIV G Sbjct: 537 SRFSPYEWHTEEFEDGE-----ESTNEFGIFNSFWFALKLFFQQGADISPRSLSARIVAG 591 Query: 625 VWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSK 684 VWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSK Sbjct: 592 VWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSK 651 Query: 685 IAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKV 744 IAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKV Sbjct: 652 IAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKV 711 Query: 745 GGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEK 804 GGNLDSKGYGIATPKGSSL VNLAVLKL+EQG+LDKLKNKWWYDKGECG+ SKEK Sbjct: 712 GGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEK 771 Query: 805 TSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMK 847 TSALSLSNVAGVFYILVGGLGLAMLVALIEF YKSRAEAKRMK Sbjct: 772 TSALSLSNVAGVFYILVGGLGLAMLVALIEFAYKSRAEAKRMK 814 >6QKC-A nrPDB Length = 915 Score = 1131 bits (2924), Expect = 0.0, Method: Composition-based stats. Identities = 596/823 (72%), Positives = 712/823 (86%), Gaps = 5/823 (0%) Query: 25 NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRG 84 N+IQIGGLFP QE++AFR + Q T +L P ID + +++SF +T FCSQFS+G Sbjct: 31 NNIQIGGLFPNQQSQEHAAFRFALSQL-TEPPKLLPQIDIVNISDSFEMTYRFCSQFSKG 89 Query: 85 VYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQ 144 VYAIFGFY++++VN +TSFCG LHV FITPSFP D ++ FV+Q+RP+L+ AL+S+I++Y+ Sbjct: 90 VYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQFVLQLRPELQEALISIIDHYK 149 Query: 145 WDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQDLELKKE 204 W F Y+YD+DRGLS LQ VLD+AAEK WQVTA+N+ +E YR LFQDLE KKE Sbjct: 150 WQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTTT----EEGYRMLFQDLEKKKE 205 Query: 205 RRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVD 264 R V++DCE +++N I+ Q++ + K+ GYHYI+ANLGF D DL K + GANV+GFQ+V+ Sbjct: 206 RLVVVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVN 265 Query: 265 YDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRR 324 Y D++ ++ +++W T + +++ KYTSALTYD V+VM EAF++LR+QRI+ISRR Sbjct: 266 YTDTIPARIMQQWRTSDSRDHTRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRR 325 Query: 325 GNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPR 384 GNAGDCLANPAVPWGQG++I+RAL+QV+ EGL+GN++F++ G+R NYT++++E+K +G R Sbjct: 326 GNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIR 385 Query: 385 KIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEG 444 KIGYW+E DK V T+ +G D S ++N+T +VTTILE PYVM+KKN EGN+RYEG Sbjct: 386 KIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEG 445 Query: 445 YCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITL 504 YCV+LAAEIAKH G+ Y+L IV DGKYGARD DTK WNGMVGELVYG+AD+A+APLTITL Sbjct: 446 YCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITL 505 Query: 505 VREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLV 564 VREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLV Sbjct: 506 VREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLV 565 Query: 565 SRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGG 624 SRFSPYEWH+EEFE+GR+ +S+ +NEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGG Sbjct: 566 SRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGG 625 Query: 625 VWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSK 684 VWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL+KQTEIAYGTL++GSTKEFFRRSK Sbjct: 626 VWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSK 685 Query: 685 IAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKV 744 IAVF+KMWTYM+SAEPSVFVRTT EG+ RVRKSKGKYAYLLESTMNEYIEQRKPCDTMKV Sbjct: 686 IAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKV 745 Query: 745 GGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEK 804 GGNLDSKGYGIATPKGS+LR VNLAVLKL+EQG+LDKLK+KWWYDKGECGS SK+K Sbjct: 746 GGNLDSKGYGIATPKGSALRGPVNLAVLKLSEQGVLDKLKSKWWYDKGECGSKDSGSKDK 805 Query: 805 TSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMK 847 TSALSLSNVAGVFYIL+GGLGLAMLVALIEFCYKSR+E+KRMK Sbjct: 806 TSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMK 848 >5KUF-A nrPDB Length = 877 Score = 995 bits (2572), Expect = 0.0, Method: Composition-based stats. Identities = 343/847 (40%), Positives = 509/847 (60%), Gaps = 46/847 (5%) Query: 23 SSNSIQIGGLF------PRGADQEYSAFRVGMVQFSTSEF---RLTPHIDNLEVANSFAV 73 +++ ++ GG+F P GA++ F V + + + LT + + +SF Sbjct: 1 TTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEA 60 Query: 74 TNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFP---TDGTHPFVIQMRP 130 + C Q S GV AIFG S N + S C L V I + +D F + + P Sbjct: 61 SKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYP 120 Query: 131 D---LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDK 187 D L A+L L+++++W +YD GL LQ ++ + + ++ + + D Sbjct: 121 DFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRL---KIRQLPADT 177 Query: 188 KDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDL 247 KD + L ++++ KE VI DC + I+ Q + +G + YHYI L D+ Sbjct: 178 KDA--KPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDV 235 Query: 248 LKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYP-----GAHTTTIKYTSALTYD 302 ++ G N++GF+I++ +++ VS IE+WS +E + P G + +AL YD Sbjct: 236 EPYRYSGVNMTGFRILNTENTQVSSIIEKWS-MERLQAPPKPDSGLLDGFMTTDAALMYD 294 Query: 303 AVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKF 362 AV V++ A + + + ++ C N PW G +K+ EGL+G I F Sbjct: 295 AVHVVSVAVQQFPQMTV------SSLQC--NRHKPWRFGTRFMSLIKEAHWEGLTGRITF 346 Query: 363 DQ-NGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTEL-PSGNDTSGLENKTVVVTT 420 ++ NG R ++ ++++ LK G KIG W + +T ++ N T L N++++VTT Sbjct: 347 NKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTT 406 Query: 421 ILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKI 480 ILE PYV+ KK+ + L GN+R+EGYC+DL E++ GF Y++ +V DGKYGA+D Sbjct: 407 ILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQ 466 Query: 481 WNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLD 540 WNGMV EL+ KAD+A+APLTIT VRE+VIDFSKPFM+LGISI+ +KP + PGVFSFL+ Sbjct: 467 WNGMVRELIDHKADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLN 526 Query: 541 PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWF 600 PL+ +IWM ++ AY+GVSVVLF+++RFSPYEW+ S N F + NS WF Sbjct: 527 PLSPDIWMYVLLAYLGVSVVLFVIARFSPYEWYNPH---PCNPDSDVVENNFTLLNSFWF 583 Query: 601 SLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL 660 +GA MQQG ++ P++LS RIVGG+WWFFTLIIISSYTANLAAFLTVERM SPI+SA+DL Sbjct: 584 GVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDL 643 Query: 661 SKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGK 720 +KQT+I YG ++ GST FF++SKI+ +DKMW +M S SV V+++ EG+ RV S Sbjct: 644 AKQTKIEYGAVEDGSTMTFFKKSKISTYDKMWAFMSSRRQSVLVKSSEEGIQRVLTS--D 701 Query: 721 YAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLL 780 YA L+EST E++ QR C+ ++GG +DSKGYG+ TP GS R+ + +A+L+L E+G L Sbjct: 702 YALLMESTTIEFVTQRN-CNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKL 760 Query: 781 DKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR 840 +K KWW G C + ++ SAL + N+ G+F +L GL L++ VA+ EF YKS+ Sbjct: 761 HMMKEKWWRGNG-CP---EEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSK 816 Query: 841 AEAKRMK 847 A+ K Sbjct: 817 KNAQLEK 823 >5IPR-B nrPDB Length = 825 Score = 735 bits (1898), Expect = 0.0, Method: Composition-based stats. Identities = 188/837 (22%), Positives = 367/837 (43%), Gaps = 127/837 (15%) Query: 58 LTPHIDNLEV--ANSFAVTNAFCSQFS----RGVY--------AIFGFYDKKSVNTITSF 103 +TP ++ + + ++ ++ C S +GV AI D SV T+T Sbjct: 59 VTPRVELVTMQESDPKSIITRICDLMSDKKVQGVVFGDDTDQEAIAQILDFISVQTLTPI 118 Query: 104 CGTLHVSFITPSFPTDGTHPFVIQMRPDLK---GALLSLIEYYQWDKFAYLYDSDRGLST 160 G S + + + + F Q P ++ +L+++E Y W F+ + G Sbjct: 119 LGIHGGSSMIMADKEEASMFF--QFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQD 176 Query: 161 LQAVLDSAAEKK---WQVTAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVN 217 + + S E W++ + +++ D D ++ + L+ ++L C +++ Sbjct: 177 FENKVRSTIENSFVGWELEEVIHLDMSLDDIDSKIQNQLKKLQ---SPVILLYCTKEEAT 233 Query: 218 DIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERW 277 I + ++G G+ +I+ +L D D + +F +G V YD Sbjct: 234 YIFEVAHSVGLTGYGFTWIVPSLVAGDTDTVPDEFP----TGLISVSYD----------- 278 Query: 278 STLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVP 337 E +Y A D + ++T A + + I + ++ + + V Sbjct: 279 ----EWDYD---------LPARVRDGIAIITTAASTMLSEHNSIPQSKSSCNNIQESRV- 324 Query: 338 WGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMEL-KTNGPRKIGYWSEVDKMV 396 + ++R L V EG ++ F ++G +++ + I+ L + ++G + + + Sbjct: 325 -YEAHMLKRYLINVTFEG--RDLSFSEDGYQMHPKLVIILLNQERKWERVGKYKDRSLKM 381 Query: 397 VTLTELPSGNDTSGLENKTVVVTTILESPYVMM---------------------KKNHEM 435 + +L ++ E + + T+ E+P+V++ + + Sbjct: 382 WPVFDLYPNSEEHKDE--HLSIVTLEEAPFVIVEDVDPLSGTCMRNTVPCRKQIRPENRT 439 Query: 436 LEG----NERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYG 491 EG +G+C+D+ +IAK F Y L +V +GK+G + +WNGM+GE+V Sbjct: 440 EEGGNYIKRCCKGFCIDILKKIAKTVKFTYDLYLVTNGKHGKKI--NGVWNGMIGEVVTK 497 Query: 492 KADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCI 550 +A +A+ LTI R EV+DFS PF+ GIS+M+ + + +FL+P + ++W M Sbjct: 498 RAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPS-AFLEPFSADVWVMMF 556 Query: 551 VFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGC 610 V I +V +F+ FSP ++ F I ++W G Sbjct: 557 VMLLIVSAVAVFVFEYFSPVGYNGPSF---------------TIGKAIWLLWGLVFNNSL 601 Query: 611 DI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQ------ 663 + +P+ + +I+ VW FF +I ++SYTANLAAF+ R V + D Q Sbjct: 602 PVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQRRYVDQVSGLSDKKFQRPNDFS 661 Query: 664 TEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAY 723 +GT+ +GST+ R + + +M +YM F + + + KS A+ Sbjct: 662 PAFRFGTVPNGSTERNIRNNYL----EMHSYMVK-----FNQRSVQDALLSLKSGKLDAF 712 Query: 724 LLESTMNEYIEQR-KPCDTMKVGGN--LDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLL 780 + ++ + Y+ R + C + +G + GYGIA K S + V+LA+L+L G + Sbjct: 713 IYDAAVLNYMAGRDEGCKLVTIGSGKVFATTGYGIAIQKDSGWKRQVDLAILQLFGDGEM 772 Query: 781 DKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCY 837 ++L+ W G C + ++ +S L + N+AGVFY+L + L+++ ++E + Sbjct: 773 EELEALWL--TGICHN--EKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIMEHLF 825 >4PE5-B nrPDB Length = 820 Score = 735 bits (1897), Expect = 0.0, Method: Composition-based stats. Identities = 190/828 (22%), Positives = 348/828 (42%), Gaps = 119/828 (14%) Query: 65 LEVANSFAVTNAFCSQFS----RGVY--------AIFGFYDKKSVNTITSFCGTLHVSFI 112 + + ++ C S +GV AI D S T+T G S + Sbjct: 47 MNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSM 106 Query: 113 TPSFPTDGTHPFVIQMRPDLK---GALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAA 169 + + + F Q P ++ +L+++E Y W F+ + G + S Sbjct: 107 IMADKDESSMFF--QFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTI 164 Query: 170 EKK---WQVTAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITI 226 E W++ + + +++ D D ++ + L+ ++L C +++ I + ++ Sbjct: 165 ENSFVGWELEEVLLLDMSLDDGDCKIQNQLKKLQ---SPIILLYCTKEEATYIFEVANSV 221 Query: 227 GKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYP 286 G GY +I+ +L D D + +F +G V YD+ W Sbjct: 222 GLTGYGYTWIVPSLVAGDTDTVPSEFP----TGLISVSYDE---------WDYG------ 262 Query: 287 GAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIER 346 A D + ++T A ++ + I ++ C Q + R Sbjct: 263 ---------LPARVRDGIAIITTAASDMLSEHSFIPEPKSS--CYNTHEKRIYQSNMLNR 311 Query: 347 ALKQVQVEGLSGNIKFDQNGKRINYTINIMEL-KTNGPRKIGYWSEVDKMVVTLTELPSG 405 L V EG ++ F ++G +++ + I+ L K ++G W + + P Sbjct: 312 YLINVTFEG--RDLSFSEDGYQMHPKLVIILLNKERKWERVGKWK-DKSLQMKYYVWPRM 368 Query: 406 NDTSGLENKTVVVTTILESPYVMM-------------------------KKNHEMLEGNE 440 + + T+ E+P+V++ K + E + Sbjct: 369 TQDD-----HLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIISENKTDEEPGYIKK 423 Query: 441 RYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPL 500 +G+C+D+ +I+K F Y L +V +GK+G + WNGM+GE+V +A +A+ L Sbjct: 424 CCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKI--NGTWNGMIGEVVMKRAYMAVGSL 481 Query: 501 TITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSV 559 TI R EV+DFS PF+ GIS+M+ + + +FL+P + +W M V I +V Sbjct: 482 TINEERSEVVDFSVPFIETGISVMVSRSNGTVSPS-AFLEPFSACVWVMMFVMLLIVSAV 540 Query: 560 VLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDI-SPRSLS 618 +F+ FSP ++ DGRE F I ++W G + +P+ + Sbjct: 541 AVFVFEYFSPVGYN-RSLADGREPGGP----SFTIGKAIWLLWGLVFNNSVPVQNPKGTT 595 Query: 619 GRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQ------TEIAYGTLD 672 +I+ VW FF +I ++SYTANLAAF+ E V + D Q +GT+ Sbjct: 596 SKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVP 655 Query: 673 SGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEY 732 +GST+ R + + +M YM F + + K+ A++ ++ + Y Sbjct: 656 NGSTERNIRNN----YAEMHAYMGK-----FNQRGVDDALLSLKTGKLDAFIYDAAVLNY 706 Query: 733 IEQR-KPCDTMKVGGN--LDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWY 789 + R + C + +G S GYGIA K S + V+LA+L+L G +++L+ W Sbjct: 707 MAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWL- 765 Query: 790 DKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCY 837 G C + ++ +S L N+AGVFY+L + L+++ + E + Sbjct: 766 -TGICHN--EKNEVMSSQLDCDNMAGVFYMLGAAMALSLITFISEHLF 810 >6IRA-D nrPDB Length = 853 Score = 703 bits (1814), Expect = 0.0, Method: Composition-based stats. Identities = 190/843 (22%), Positives = 356/843 (42%), Gaps = 124/843 (14%) Query: 65 LEVANSFAVTNAFCSQFS----RGVY--------AIFGFYDKKSVNTITSFCGTLHVSFI 112 + + ++ C S G+ A+ D S +T G + + Sbjct: 74 MNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILGIHGGASM 133 Query: 113 TPSFPTDGTHPFVIQMRPDLKG---ALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAA 169 + + F Q ++ +L +++ Y W F+ + G + + + Sbjct: 134 IMADKDPTSTFF--QFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFISFVKTTV 191 Query: 170 EKK---WQVTAINVGNINNDKKDEMYRSLFQDLELKKER--RVILDCERDKVNDIVDQVI 224 + W + N D + ++LKK ++L C +D+ I+ + Sbjct: 192 DNSFVGWDMQ-------NVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEAR 244 Query: 225 TIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKE 284 ++G + +I+ +L + +L+ +F SG V YDD W E Sbjct: 245 SLGLTGYDFFWIVPSLVSGNTELIPKEFP----SGLISVSYDD---------WDYSLE-- 289 Query: 285 YPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAG-DCLANPAVPWGQGVE 343 A D + ++T A ++ ++ I + + P VP Sbjct: 290 -------------ARVRDGIGILTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHT--- 333 Query: 344 IERALKQVQVEGLSGNIKFDQNGKRINYTINIMEL-KTNGPRKIGYWSEVDKMVVTLTEL 402 + + V +G ++ F + G +++ + ++ L K K+G W E + + Sbjct: 334 LHPFMVNVTWDG--KDLSFTEEGYQVHPRLVVIVLNKDREWEKVGKW-ENHTLSLRHAVW 390 Query: 403 PSGNDTSGLE--NKTVVVTTILESPYVMMK------------------------KNHEML 436 P S E + + + T+ E+P+V+++ +E + Sbjct: 391 PRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGM 450 Query: 437 EGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIA 496 + +G+C+D+ ++++ F Y L +V +GK+G + + +WNGM+GE+VY +A +A Sbjct: 451 NVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNN--VWNGMIGEVVYQRAVMA 508 Query: 497 IAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYI 555 + LTI R EV+DFS PF+ GIS+M+ + + +FL+P + +W M V I Sbjct: 509 VGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPS-AFLEPFSASVWVMMFVMLLI 567 Query: 556 GVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDI-SP 614 ++ +F+ FSP ++ G+ F I ++W G + +P Sbjct: 568 VSAIAVFVFEYFSPVGYN-RNLAKGKAPHGP----SFTIGKAIWLLWGLVFNNSVPVQNP 622 Query: 615 RSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQ------TEIAY 668 + + +I+ VW FF +I ++SYTANLAAF+ R V + D Q + Sbjct: 623 KGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQRRFVDQVTGLSDKKFQRPHDYSPPFRF 682 Query: 669 GTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLEST 728 GT+ +GST+ R + + M YM F + E K+ A++ ++ Sbjct: 683 GTVPNGSTERNIRNN----YPYMHQYMTK-----FNQKGVEDALVSLKTGKLDAFIYDAA 733 Query: 729 MNEYIEQR-KPCDTMKVGGN--LDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKN 785 + Y R + C + +G + GYGIA KGS + ++LA+L+ G +++L+ Sbjct: 734 VLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELET 793 Query: 786 KWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEF-CYKSRAEAK 844 W G C + ++ +S L + N+AGVFY+L + L+++ + E YKSRAEAK Sbjct: 794 LWL--TGICHN--EKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYKSRAEAK 849 Query: 845 RMK 847 RMK Sbjct: 850 RMK 852 >5UP2-B nrPDB Length = 831 Score = 695 bits (1792), Expect = 0.0, Method: Composition-based stats. Identities = 182/845 (21%), Positives = 348/845 (41%), Gaps = 125/845 (14%) Query: 53 TSEFRLTPHIDNLEV----ANSFAVTNAFCSQFS----RGVY--------AIFGFYDKKS 96 T + L ++ + + + ++ C S GV AI D S Sbjct: 50 TRDMSLDFDVNVVTLLVQQTDPKSIITHVCDLMSGTKIHGVVFGDDTDQEAIAQILDFVS 109 Query: 97 VNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKG---ALLSLIEYYQWDKFAYLYD 153 T G S + + + + F Q +K +L+++E Y W F+ + Sbjct: 110 SQTFIPILGIHGGSSMIMADKDEMSTFF--QFGASIKQQATVMLNIMEEYDWHVFSVITS 167 Query: 154 SDRGLSTLQAVLDSAAEKK---WQVTAINVGNINNDKKDEMYRSLFQDLELKKER--RVI 208 + G + + + + W+V N D Y +LKK ++ Sbjct: 168 NFPGYRDFISFIKTTVDNSFVGWEVQ-------NYITLDTSYTDAQTLTQLKKIHSSVIL 220 Query: 209 LDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDS 268 L C +D+ I ++ ++G G+ +I+ +L + D++ +F SG V YDD Sbjct: 221 LYCSKDEATYIFEEARSLGLMGYGFVWIVPSLVTGNTDIIPYEFP----SGLVSVSYDD- 275 Query: 269 LVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAG 328 W E A D + ++T A + ++ I + Sbjct: 276 --------WDYGIE---------------ARVRDGLGIITTAASAMLEKHSVIPEAKTS- 311 Query: 329 DCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELK-TNGPRKIG 387 C + + V +G ++ F ++G + N + ++ L K+G Sbjct: 312 -CYGQNERNDPPLHTLHNFMINVTWDG--KDLSFTEDGYQANPKLVVLLLNMEREWEKVG 368 Query: 388 YWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKK---------------- 431 W E + + P + S ++ + + T+ E+P+V+++ Sbjct: 369 KW-EAKSLNMKYPVWPRID--SDHDDNHLSIVTLEEAPFVIVENIDYLTGTCVRNTVPCR 425 Query: 432 --------NHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNG 483 E + +G+C+D+ +++K F Y L +V +GK+G + + +WNG Sbjct: 426 KYFRLANSTTEGTSVKKCCKGFCIDILKKLSKTVKFTYDLYLVTNGKHGKKIKN--VWNG 483 Query: 484 MVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLA 543 M+GE+VY +A +A+ LTI R +DFS PF+ GIS+M+ + + +FL+P + Sbjct: 484 MIGEVVYKRAVMAVGSLTINEERSVAVDFSVPFVETGISVMVSRSAGTVSPS-AFLEPFS 542 Query: 544 YEIW-MCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSL 602 +W M V + ++ +F+ FSP ++ G++ F I ++W Sbjct: 543 ASVWVMMFVMLLLVSAMAVFIFEYFSPVGYN-RNLAQGKDPHGP----SFTIGKAVWLLW 597 Query: 603 GAFMQQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLS 661 G + +P+ + +I+ +W FF +I ++SYTANLAAF+ R V + D Sbjct: 598 GLVFNNSLPVQNPKGTTSKIIVSIWAFFAVIFLASYTANLAAFMIQRRFVDQVTGLSDNK 657 Query: 662 KQ------TEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVR 715 Q +GT+ GST+ R + + M YM F + + Sbjct: 658 FQRPHDYSPPFRFGTVPQGSTERNIRNN----YPDMHQYMVK-----FHQKGVQDALVSL 708 Query: 716 KSKGKYAYLLESTMNEYIEQR-KPCDTMKVGGN--LDSKGYGIATPKGSSLRNAVNLAVL 772 K+ A++ ++ + Y+ R + C + +G + GYGIA KGS + ++LA+L Sbjct: 709 KTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGYIFATTGYGIALQKGSRWKRPIDLALL 768 Query: 773 KLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVAL 832 + G +++L+ W G C + ++ +S L + N+AGVFY+L + L+++ + Sbjct: 769 QFVGDGEMEELEKLWL--TGICHT--EKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFV 824 Query: 833 IEFCY 837 E + Sbjct: 825 WEHLF 829 >5KUH-A nrPDB Length = 757 Score = 612 bits (1577), Expect = e-175, Method: Composition-based stats. Identities = 194/608 (31%), Positives = 309/608 (50%), Gaps = 42/608 (6%) Query: 23 SSNSIQIGGLF------PRGADQEYSAFRVGMVQFSTSEF---RLTPHIDNLEVANSFAV 73 +++ ++ GG+F P GA++ F V + + + LT + + +SF Sbjct: 1 TTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEA 60 Query: 74 TNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFP---TDGTHPFVIQMRP 130 + C Q S GV AIFG S N + S C L V I + +D F + + P Sbjct: 61 SKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYP 120 Query: 131 D---LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDK 187 D L A+L L+++++W +YD GL LQ ++ + + ++ + + D Sbjct: 121 DFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRL---KIRQLPADT 177 Query: 188 KDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDL 247 KD + L ++++ KE VI DC + I+ Q + +G + YHYI L D+ Sbjct: 178 KDA--KPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDV 235 Query: 248 LKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYP-----GAHTTTIKYTSALTYD 302 ++ G N++GF+I++ +++ VS IE+WS +E + P G + +AL YD Sbjct: 236 EPYRYSGVNMTGFRILNTENTQVSSIIEKWS-MERLQAPPKPDSGLLDGFMTTDAALMYD 294 Query: 303 AVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKF 362 AV V++ A + + + ++ C N PW G +K+ EGL+G I F Sbjct: 295 AVHVVSVAVQQFPQMTV------SSLQC--NRHKPWRFGTRFMSLIKEAHWEGLTGRITF 346 Query: 363 DQ-NGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTEL-PSGNDTSGLENKTVVVTT 420 ++ NG R ++ ++++ LK G KIG W + +T ++ N T L N++++VTT Sbjct: 347 NKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTT 406 Query: 421 ILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKI 480 ILE PYV+ KK+ + L GN+R+EGYC+DL E++ GF Y++ +V DGKYGA+D Sbjct: 407 ILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQ 466 Query: 481 WNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLD 540 WNGMV EL+ KAD+A+APLTIT VRE+VIDFSKPFM+LGISI+ +K D Sbjct: 467 WNGMVRELIDHKADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKG-----TPIDSAD 521 Query: 541 PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWF 600 LA + + G ++ F S+ S Y+ F R ++E GI L Sbjct: 522 DLAKQTKIEYGAVEDGSTMTFFKKSKISTYD-KMWAFMSSRRQSVLVKSSEEGIQRVLTS 580 Query: 601 SLGAFMQQ 608 M+ Sbjct: 581 DYALLMES 588 Score = 268 bits (684), Expect = 9e-72, Method: Composition-based stats. Identities = 89/202 (44%), Positives = 133/202 (65%), Gaps = 7/202 (3%) Query: 646 TVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVR 705 + R +PI+SA+DL+KQT+I YG ++ GST FF++SKI+ +DKMW +M S SV V+ Sbjct: 509 ILYRKGTPIDSADDLAKQTKIEYGAVEDGSTMTFFKKSKISTYDKMWAFMSSRRQSVLVK 568 Query: 706 TTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRN 765 ++ EG+ RV S YA L+EST E++ QR C+ ++GG +DSKGYG+ TP GS R+ Sbjct: 569 SSEEGIQRVLTS--DYALLMESTTIEFVTQRN-CNLTQIGGLIDSKGYGVGTPMGSPYRD 625 Query: 766 AVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLG 825 + +A+L+L E+G L +K KWW G C + ++ SAL + N+ G+F +L GL Sbjct: 626 KITIAILQLQEEGKLHMMKEKWWRGNG-CP---EEESKEASALGVQNIGGIFIVLAAGLV 681 Query: 826 LAMLVALIEFCYKSRAEAKRMK 847 L++ VA+ EF YKS+ A+ K Sbjct: 682 LSVFVAVGEFLYKSKKNAQLEK 703 >5UOW-A nrPDB Length = 814 Score = 593 bits (1529), Expect = e-169, Method: Composition-based stats. Identities = 216/878 (24%), Positives = 376/878 (42%), Gaps = 132/878 (15%) Query: 26 SIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVA---NSFAVTNAFC-SQF 81 + IG + + FR + Q + F ++ V N+ + + C Sbjct: 4 IVNIGAVL--STKKHEQIFREAVNQANKRHFTRKIQLNATSVTHRPNAIQMALSVCEDLI 61 Query: 82 SRGVYAIF-----GFYDKKSVNTITSFCGTLHVSFI----TPSFPTDGTH--PFVIQMRP 130 S VYAI D + I+ G + I S +D + F+ + P Sbjct: 62 SSQVYAILVSHPPAPTDHLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTVPP 121 Query: 131 DLKGALL--SLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKK 188 AL+ ++ + W+ + D Q L++ E+K + A V K Sbjct: 122 YSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEEK-ESKADKVLQFEPGTK 180 Query: 189 DEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLL 248 + +L + + + R +IL D + + GY +++ + L Sbjct: 181 N--LTALLLEAKELEARVIILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGSAL- 237 Query: 249 KIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMT 308 ++ + G Q+++ K SA DAV V+ Sbjct: 238 --RYAPDGIIGLQLIN----------------------------GKNESAHISDAVAVVA 267 Query: 309 EAFRNL-RKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQV-EGLSGNIKFDQNG 366 +A L ++I RG C+ N + W G +R L + +G++G I+F+++G Sbjct: 268 QAIHELFEMEQITDPPRG----CVGNTNI-WKTGPLFKRVLMSSKYPDGVTGRIEFNEDG 322 Query: 367 KRINYTINIMELKTNGPRKIG-----YWSEVDKMVV---TLTELPSGNDTSGLENKTVVV 418 R +IM L+ ++G Y + D+ ++ TE P G S + + Sbjct: 323 DRKFAQYSIMNLQNRKLVQVGIFDGSYIIQNDRKIIWPGGETERPQGYQMS----TRLKI 378 Query: 419 TTILESPYVMMKKNHEMLEGNERYE-----------------------------GYCVDL 449 TI + P+V ++ E Y G+CVDL Sbjct: 379 VTIHQEPFVYVRPTTSDGTCREEYTINGDPIKKVICNGPDETIPGRPTVPQCCYGFCVDL 438 Query: 450 AAEIAKHCGFKYKLTIVGDGKYGAR----DADTKIWNGMVGELVYGKADIAIAPLTITLV 505 ++A+ F Y++ +V DGK+G + +++ WNGM+GEL+ G+AD+ +APLTI Sbjct: 439 LIKLAREMDFTYEVHLVADGKFGTQERVNNSNAAAWNGMMGELLSGQADMIVAPLTINNE 498 Query: 506 REEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVS 565 R + I+FSKPF G++I++KK + + SF+ P +W+ + + V+V+L+L+ Sbjct: 499 RAQYIEFSKPFKYQGLTILVKKE-IPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLD 557 Query: 566 RFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGC-DISPRSLSGRIVGG 624 RFSP F + ++ + + +++WFS + G + +PRS S RI+G Sbjct: 558 RFSP-------FGRFKVNSAAAEEDALTLSSAMWFSWRVLLNSGLGEGAPRSFSARILGM 610 Query: 625 VWWFFTLIIISSYTANLAAFLTVER---MVSPIESAEDLSKQTEIAYGTLDSGSTKEFFR 681 VW F +II++SYTANLAAFL + R ++ I + + Y T+ S +FR Sbjct: 611 VWALFAMIIVASYTANLAAFLVLRRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFR 670 Query: 682 RSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDT 741 R M+ +M + AE + VR +K +A++ +S + E+ E + CD Sbjct: 671 RQ--VELSTMYRHMEKHN----YESAAEAIQAVRDNK-LHAFIWDSAVLEF-EASQDCDL 722 Query: 742 MKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDS 801 + G G+GI K S + V+L +LK +E G +++L +K W EC DS Sbjct: 723 VTTGELFFRSGFGIGMRKDSPWKQEVSLNILKSHENGFMEEL-DKTWVRYQEC-----DS 776 Query: 802 KEKTSA-LSLSNVAGVFYILVGGLGLAMLVALIEFCYK 838 + A L+ N+AGVFY++ GG+ + + IE YK Sbjct: 777 RSNAPATLTFENMAGVFYLVAGGIVAGIFLIFIEIAYK 814 >5FXI-A nrPDB Length = 846 Score = 593 bits (1528), Expect = e-169, Method: Composition-based stats. Identities = 210/901 (23%), Positives = 373/901 (41%), Gaps = 145/901 (16%) Query: 26 SIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNL-EVANSFAVTNAFC-SQFSR 83 + IG + ++ V +++ ++ N+ + + C S Sbjct: 4 IVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQLQATSVTHKPNAIQMALSVCEDLISS 63 Query: 84 GVYAIF-----GFYDKKSVNTITSFCGTLHVSFI--TPSFPTDGTHPFVIQM------RP 130 VYAI D + ++ G + + T + Sbjct: 64 QVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYS 123 Query: 131 DLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAE----KKWQVTAINVGNINND 186 ++ Y W+ L D Q L++ E K + N+ ++ D Sbjct: 124 HQSSVWFEMMRVYNWNHIILLVSDDHEGRAAQKRLETLLEERESKSKKRNYENLDQLSYD 183 Query: 187 KK--------------DEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKG 232 K + +L + + R +IL D + + G Sbjct: 184 NKRGPKAEKVLQFDPGTKNVTALLMEARELEARVIILSASEDDAATVYRAAAMLDMTGSG 243 Query: 233 YHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTT 292 Y +++ G + +++ + G Q+++ Sbjct: 244 YVWLV---GEREISGNALRYAPDGIIGLQLIN---------------------------- 272 Query: 293 IKYTSALTYDAVQVMTEAFRNLRK-QRIEISRRGNAGDCLANPAVPWGQGVEIERALKQV 351 K SA DAV V+ +A L + + I RG C+ N + W G +R L Sbjct: 273 GKNESAHISDAVGVVAQAVHELLEKENITDPPRG----CVGNTNI-WKTGPLFKRVLMSS 327 Query: 352 QV-EGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWS-----EVDKMVV---TLTEL 402 + +G++G ++F+++G R +IM L+ ++G ++ D+ ++ TE Sbjct: 328 KYADGVTGRVEFNEDGDRKFAQYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEK 387 Query: 403 PSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYE------------------- 443 P G S + + TI + P+V +K E + Sbjct: 388 PRGYQMS----TRLKIVTIHQEPFVYVKPTMSDGTCKEEFTVNGDPVKKVICTGPNDTSP 443 Query: 444 ------------GYCVDLAAEIAKHCGFKYKLTIVGDGKYGAR----DADTKIWNGMVGE 487 G+C+DL ++A+ F Y++ +V DGK+G + +++ K WNGM+GE Sbjct: 444 GSPRHTVPQCCYGFCIDLLIKLARTMQFTYEVHLVADGKFGTQERVQNSNKKEWNGMMGE 503 Query: 488 LVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW 547 L+ G+AD+ +APLTI R + I+FSKPF G++I++KK + + SF+ P +W Sbjct: 504 LLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKE-IPRSTLDSFMQPFQSTLW 562 Query: 548 MCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQ 607 + + + V+V+L+L+ RFSP F + SEST+ + +++WFS G + Sbjct: 563 LLVGLSVHVVAVMLYLLDRFSP-------FGRFKVNSQSESTDALTLSSAMWFSWGVLLN 615 Query: 608 QGC-DISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVER---MVSPIESAEDLSKQ 663 G + +PRS S RI+G VW F +II++SYTANLAAFL ++R ++ I + Sbjct: 616 SGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPS 675 Query: 664 TEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAY 723 + Y T+ S +FRR M+ +M + AE + VR +K +A+ Sbjct: 676 DKFIYATVKQSSVDIYFRRQ--VELSTMYRHMEKHN----YESAAEAIQAVRDNK-LHAF 728 Query: 724 LLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKL 783 + +S + E+ E + CD + G G+GI K S + V+L++LK +E G ++ L Sbjct: 729 IWDSAVLEF-EASQKCDLVTTGELFFRSGFGIGMRKDSPWKQQVSLSILKSHENGFMEDL 787 Query: 784 KNKWWYDKGECGSGGGDSKEKTSA-LSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAE 842 +K W EC DS+ A L+ N+AGVF ++ GG+ + + IE YK + Sbjct: 788 -DKTWVRYQEC-----DSRSNAPATLTCENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKD 841 Query: 843 A 843 A Sbjct: 842 A 842 >5L2E-A nrPDB Length = 688 Score = 503 bits (1294), Expect = e-142, Method: Composition-based stats. Identities = 138/589 (23%), Positives = 254/589 (43%), Gaps = 61/589 (10%) Query: 23 SSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEF-----RLTPHIDNLEVANSFAVTNAF 77 S + I IG +F A ++ FR + + +E ++T + ++ N F Sbjct: 2 SDSIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEA 61 Query: 78 CSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGT-------------HPF 124 C ++G+ A+ S ++ S +H+ + T GT + Sbjct: 62 CELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDY 121 Query: 125 VIQMRPD--LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGN 182 + +RP L +L ++ Y W KF YDS+ + +Q LD +++ V V N Sbjct: 122 TLSVRPPVYLNEVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVEN 181 Query: 183 INNDKKDEMYRSLFQDLELKK-------ERRVILDCERDKVNDIVDQVITIGKHVKGYHY 235 ++M +LF + +++ RR IL + +V+ H+ Sbjct: 182 ----NINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFISEVVETNLVAFDCHW 237 Query: 236 IIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERW--------STLEEKEYPG 287 II N D D+ ++ ++ I+ + +R STL + + P Sbjct: 238 IIINEEINDVDVQELV--RRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPF 295 Query: 288 AHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERA 347 A I ++ YD V ++ AF + R S + C+ + PW G + Sbjct: 296 AQNMEI--SNLYIYDTVLLLANAFHKKLQDRKWHSMASLS--CIRKNSKPWQGGRSMLET 351 Query: 348 LKQVQVEGLSGNIKFDQNGKRINYTINIM-----ELKTNGPRKIGYWSEVDKMVVTLTEL 402 +K+ V GL+G+++F +NG N I+ E G RK+G W+ V + +LT+ Sbjct: 352 IKKGGVNGLTGDLEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDK 411 Query: 403 PSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYK 462 N+ G+ + V T+LE P+VM+ +N +L ++Y+G+ +D+ ++ + GF Y+ Sbjct: 412 KLENNMRGV---VLRVVTVLEEPFVMVSEN--VLGKPKKYQGFSIDVLDALSNYLGFNYE 466 Query: 463 LTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGIS 522 + + D KYG+ D WNG+VGELV+ +ADI I+ LTIT RE V+DF+ +M + Sbjct: 467 IYVAPDHKYGSPQED-GTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVG 525 Query: 523 IMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYE 571 +++++ L L+ + + + +P+E Sbjct: 526 VLLRRG-----TSIQSLQDLSKQTDIPYGTVLDSAVYQHVRMKGLNPFE 569 Score = 174 bits (441), Expect = 2e-43, Method: Composition-based stats. Identities = 50/158 (31%), Positives = 82/158 (51%), Gaps = 10/158 (6%) Query: 646 TVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDK------MWTYM-RSA 698 + R + I+S +DLSKQT+I YGT+ + + R + F++ MW + RS Sbjct: 526 VLLRRGTSIQSLQDLSKQTDIPYGTVLDSAVYQHVRMKGLNPFERDSMYSQMWRMINRSN 585 Query: 699 EPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKP-CDTMKVGGNLDSKGYGIAT 757 V + G+ +V+ G YA++ ++ + EY+ P C VG + +GYGIA Sbjct: 586 GSENNVLESQAGIQKVKY--GNYAFVWDAAVLEYVAINDPDCSFYTVGNTVADRGYGIAL 643 Query: 758 PKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECG 795 GS R+ + +L+L + G +D LK+KWW G+C Sbjct: 644 QHGSPYRDVFSQRILELQQSGDMDILKHKWWPKNGQCD 681 >5UN1-B nrPDB Length = 448 Score = 466 bits (1199), Expect = e-131, Method: Composition-based stats. Identities = 140/475 (29%), Positives = 233/475 (49%), Gaps = 52/475 (10%) Query: 391 EVDKMVVTLTELP--SGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEG----NERYEG 444 + +VTL E P D L T + T+ ++ + EG +G Sbjct: 1 DEHLSIVTLEEAPFVIVEDVDPLSG-TCMRNTVPCRK--QIRPENRTEEGGNYIKRCCKG 57 Query: 445 YCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITL 504 +C+D+ +IAK F Y L +V +GK+G + +WNGM+GE+V +A +A+ LTI Sbjct: 58 FCIDILKKIAKTVKFTYDLYLVTNGKHGKKI--NGVWNGMIGEVVTKRAYMAVGSLTINE 115 Query: 505 VREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVLFL 563 R EV+DFS PF+ GIS+M+ + + +FL+P + ++W M V I +V +F+ Sbjct: 116 ERSEVVDFSVPFIETGISVMVSRSNGTVSPS-AFLEPFSADVWVMMFVMLLIVSAVAVFV 174 Query: 564 VSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDI-SPRSLSGRIV 622 FSP ++ F I ++W G + +P+ + +I+ Sbjct: 175 FEYFSPVGYNGPSF---------------TIGKAIWLLWGLVFNNSLPVQNPKGTTSKIM 219 Query: 623 GGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQ------TEIAYGTLDSGST 676 VW FF +I ++SYTANLAAF+ R V + D Q +GT+ +GST Sbjct: 220 VSVWAFFAVIFLASYTANLAAFMIQRRYVDQVSGLSDKKFQRPNDFSPAFRFGTVPNGST 279 Query: 677 KEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR 736 + R + + +M +YM F + + + KS A++ ++ + Y+ R Sbjct: 280 ERNIRNNYL----EMHSYMVK-----FNQRSVQDALLSLKSGKLDAFIYDAAVLNYMAGR 330 Query: 737 -KPCDTMKVGGN--LDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGE 793 + C + +G + GYGIA K S + V+LA+L+L G +++L+ W G Sbjct: 331 DEGCKLVTIGSGKVFATTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWL--TGI 388 Query: 794 CGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEF-CYKSRAEAKRMK 847 C + ++ +S L + N+AGVFY+L + L+++ ++E YKSRAEAKRMK Sbjct: 389 CHN--EKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIMEHLFYKSRAEAKRMK 441 >5UN1-G nrPDB Length = 451 Score = 466 bits (1199), Expect = e-131, Method: Composition-based stats. Identities = 148/472 (31%), Positives = 237/472 (50%), Gaps = 68/472 (14%) Query: 414 KTVVVTTILESPYVMMKKNHEMLEGNERYE-----------------------------G 444 + + TI + P+V ++ E Y G Sbjct: 3 TRLKIVTIHQEPFVYVRPTTSDGTCREEYTINGDPIKKVICNGPDETIPGRPTVPQCCYG 62 Query: 445 YCVDLAAEIAKHCGFKYKLTIVGDGKYGAR----DADTKIWNGMVGELVYGKADIAIAPL 500 +CVDL ++A+ F Y++ +V DGK+G + +++ WNGM+GEL+ G+AD+ +APL Sbjct: 63 FCVDLLIKLAREMDFTYEVHLVADGKFGTQERVNNSNAAAWNGMMGELLSGQADMIVAPL 122 Query: 501 TITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVV 560 TI R + I+FSKPF G++I++KK + + SF+ P +W+ + + V+V+ Sbjct: 123 TINNERAQYIEFSKPFKYQGLTILVKKE-IPRSTLDSFMQPFQSTLWLLVGLSVHVVAVM 181 Query: 561 LFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGC-DISPRSLSG 619 L+L+ RFSP+ FED + +++WFS + G + +PRS S Sbjct: 182 LYLLDRFSPFG----RFEDA-----------LTLSSAMWFSWRVLLNSGLGEGAPRSFSA 226 Query: 620 RIVGGVWWFFTLIIISSYTANLAAFLTVER---MVSPIESAEDLSKQTEIAYGTLDSGST 676 RI+G VW F +II++SYTANLAAFL + R ++ I + + Y T+ S Sbjct: 227 RILGMVWAGFAMIIVASYTANLAAFLVLRRPEERITGINDPRLRNPSDKFIYATVKQSSV 286 Query: 677 KEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR 736 +FRR M+ +M + AE + VR +K +A++ +S + E+ E Sbjct: 287 DIYFRRQ--VELSTMYRHMEKHN----YESAAEAIQAVRDNK-LHAFIWDSAVLEF-EAS 338 Query: 737 KPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGS 796 + CD + G G+GI K S + V+L +LK +E G +++L +K W EC Sbjct: 339 QKCDLVTTGELFFRSGFGIGMRKDSPWKQEVSLNILKSHENGFMEEL-DKTWVRYQEC-- 395 Query: 797 GGGDSKEKTSA-LSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMK 847 DS+ A L+ N+AGVF ++ GG+ + + IE YKSRAEAKRMK Sbjct: 396 ---DSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKSRAEAKRMK 444 >5O9A-A nrPDB Length = 264 Score = 229 bits (584), Expect = 4e-60, Method: Composition-based stats. Identities = 143/149 (95%), Positives = 146/149 (97%) Query: 649 RMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTA 708 + +PIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTA Sbjct: 116 KKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTA 175 Query: 709 EGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVN 768 EGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSL NAVN Sbjct: 176 EGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVN 235 Query: 769 LAVLKLNEQGLLDKLKNKWWYDKGECGSG 797 LAVLKL+EQGLLDKLKNKWWYDKGECGSG Sbjct: 236 LAVLKLSEQGLLDKLKNKWWYDKGECGSG 264 Score = 196 bits (499), Expect = 3e-50, Method: Composition-based stats. Identities = 121/183 (66%), Positives = 132/183 (72%), Gaps = 6/183 (3%) Query: 412 ENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKY 471 NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKY Sbjct: 2 ANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKY 61 Query: 472 GARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKS 531 GARDADTKIWNGMVGELVYGKADIAIAPLTIT VREEVIDFSKPFMSLGISIMIKK Sbjct: 62 GARDADTKIWNGMVGELVYGKADIAIAPLTITYVREEVIDFSKPFMSLGISIMIKKG--- 118 Query: 532 KPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNE 591 + L+ + + G + F S+ + ++ + E T Sbjct: 119 --TPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFD-KMWTYMRSAEPSVFVRTTA 175 Query: 592 FGI 594 G+ Sbjct: 176 EGV 178 >3FAT-A nrPDB Length = 260 Score = 228 bits (581), Expect = 8e-60, Method: Composition-based stats. Identities = 131/147 (89%), Positives = 141/147 (95%) Query: 649 RMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTA 708 + +PIESAEDL+KQTEIAYGTLDSGSTKEFFRRSKIAV++KMWTYMRSAEPSVF RTTA Sbjct: 114 KKGTPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTA 173 Query: 709 EGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVN 768 EGVARVRKSKGK+A+LLESTMNEYIEQRKPCDTMKVGGNLDSKGYG+ATPKGSSLR VN Sbjct: 174 EGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVN 233 Query: 769 LAVLKLNEQGLLDKLKNKWWYDKGECG 795 LAVLKL+E G+LDKLKNKWWYDKGECG Sbjct: 234 LAVLKLSEAGVLDKLKNKWWYDKGECG 260 Score = 189 bits (479), Expect = 5e-48, Method: Composition-based stats. Identities = 111/182 (60%), Positives = 126/182 (69%), Gaps = 6/182 (3%) Query: 413 NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYG 472 +TVVVTTI+ESPYVM KKNHEM EGN++YEGYCVDLA+EIAKH G KYK+ IV DGKYG Sbjct: 1 GRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYG 60 Query: 473 ARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSK 532 ARDADTKIWNGMVGELVYGKA+IAIAPLTITLVREEVIDFSKPFMSLGISIMIKK Sbjct: 61 ARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKG---- 116 Query: 533 PGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEF 592 + LA + + G + F S+ + YE + E T Sbjct: 117 -TPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYE-KMWTYMRSAEPSVFTRTTAE 174 Query: 593 GI 594 G+ Sbjct: 175 GV 176 >1YAE-A nrPDB Length = 312 Score = 226 bits (577), Expect = 2e-59, Method: Composition-based stats. Identities = 95/226 (42%), Positives = 127/226 (56%), Gaps = 21/226 (9%) Query: 403 PSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYK 462 N T L N++++VTTILE PYV+ KK+ + L GN+R+EGYC+DL E++ GF Y+ Sbjct: 2 KPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYE 61 Query: 463 LTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGIS 522 + +V DGKYGA+D WNGMV EL+ KAD+A+APL IT VRE+VIDFSKPFM+LGIS Sbjct: 62 IRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGIS 121 Query: 523 IMIKKPQKSKPGVFSFL--------------------DPLAYEIWMCIVFAYIGVSVVLF 562 I+ +KP + PGVFSFL D LA + + G ++ F Sbjct: 122 ILYRKPNGTNPGVFSFLNGGSLVPRGSERMESPIDSADDLAKQTKIEYGAVEDGATMTFF 181 Query: 563 LVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQ 608 S+ S Y+ F R +NE GI L M+ Sbjct: 182 KKSKISTYD-KMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMES 226 Score = 220 bits (561), Expect = 2e-57, Method: Composition-based stats. Identities = 76/165 (46%), Positives = 111/165 (67%), Gaps = 7/165 (4%) Query: 648 ERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTT 707 ERM SPI+SA+DL+KQT+I YG ++ G+T FF++SKI+ +DKMW +M S SV V++ Sbjct: 149 ERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSN 208 Query: 708 AEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAV 767 EG+ RV S YA+L+EST E++ QR C+ ++GG +DSKGYG+ TP GS R+ + Sbjct: 209 EEGIQRVLTS--DYAFLMESTTIEFVTQRN-CNLTQIGGLIDSKGYGVGTPMGSPYRDKI 265 Query: 768 NLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSN 812 +A+L+L E+G L +K KWW G C + ++ SAL + N Sbjct: 266 TIAILQLQEEGKLHMMKEKWWRGNG-CP---EEESKEASALGVQN 306 >3DP4-A nrPDB Length = 278 Score = 226 bits (577), Expect = 2e-59, Method: Composition-based stats. Identities = 126/147 (85%), Positives = 141/147 (95%) Query: 649 RMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTA 708 + +PIESAEDL+KQTEIAYGTLDSGSTKEFFRRSKIAV++KMW+YM+SAEPSVF +TTA Sbjct: 132 KKGTPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTA 191 Query: 709 EGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVN 768 +GVARVRKSKGK+A+LLESTMNEYIEQRKPCDTMKVGGNLDSKGYG+ATPKGS+L VN Sbjct: 192 DGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVN 251 Query: 769 LAVLKLNEQGLLDKLKNKWWYDKGECG 795 LAVLKL+EQG+LDKLKNKWWYDKGECG Sbjct: 252 LAVLKLSEQGILDKLKNKWWYDKGECG 278 Score = 196 bits (499), Expect = 2e-50, Method: Composition-based stats. Identities = 116/200 (58%), Positives = 134/200 (67%), Gaps = 6/200 (3%) Query: 395 MVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIA 454 +V + + ND+S N+T+VVTTILESPYVM KKNHE LEGNERYEGYCVDLA EIA Sbjct: 1 LVPRGSAMGISNDSSRGANRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIA 60 Query: 455 KHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSK 514 KH KYKL+IVGDGKYGARD +TKIWNGMVGELVYG+ADIA+APLTITLVREEVIDFSK Sbjct: 61 KHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSK 120 Query: 515 PFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHT 574 PFMSLGISIMIKK + LA + + G + F S+ + YE Sbjct: 121 PFMSLGISIMIKKG-----TPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYE-KM 174 Query: 575 EEFEDGRETQSSESTNEFGI 594 + E T G+ Sbjct: 175 WSYMKSAEPSVFTKTTADGV 194 >2XXT-A nrPDB Length = 261 Score = 213 bits (543), Expect = 2e-55, Method: Composition-based stats. Identities = 69/153 (45%), Positives = 102/153 (66%), Gaps = 4/153 (2%) Query: 646 TVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVR 705 + R +PI+SA+DL+KQT+I YG ++ G+T FF++SKI+ +DKMW +M S SV V+ Sbjct: 113 ILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVK 172 Query: 706 TTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRN 765 + EG+ RV S YA+L+EST E++ QR C+ ++GG +DSKGYG+ TP GS R+ Sbjct: 173 SNEEGIQRVLTS--DYAFLMESTTIEFVTQRN-CNLTQIGGLIDSKGYGVGTPMGSPYRD 229 Query: 766 AVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGG 798 + +A+L+L E+G L +K KWW G C Sbjct: 230 KITIAILQLQEEGKLHMMKEKWWRGNG-CPEPR 261 Score = 209 bits (531), Expect = 6e-54, Method: Composition-based stats. Identities = 84/197 (42%), Positives = 115/197 (58%), Gaps = 6/197 (3%) Query: 412 ENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKY 471 N++++VTTILE PYV+ KK+ + L GN+R+EGYC+DL E++ GF Y++ +V DGKY Sbjct: 2 SNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKY 61 Query: 472 GARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKS 531 GA+D WNGMV EL+ KAD+A+APL IT VRE+VIDFSKPFM+LGISI+ +K Sbjct: 62 GAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKG--- 118 Query: 532 KPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNE 591 D LA + + G ++ F S+ S Y+ F R +NE Sbjct: 119 --TPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYD-KMWAFMSSRRQSVLVKSNE 175 Query: 592 FGIFNSLWFSLGAFMQQ 608 GI L M+ Sbjct: 176 EGIQRVLTSDYAFLMES 192 >4MF3-A nrPDB Length = 261 Score = 210 bits (534), Expect = 2e-54, Method: Composition-based stats. Identities = 69/153 (45%), Positives = 101/153 (66%), Gaps = 4/153 (2%) Query: 646 TVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVR 705 + R +PI+SA+DL+KQT+I YG + GST FF++SKI+ ++KMW +M S + + VR Sbjct: 113 ILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVR 172 Query: 706 TTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRN 765 + EG+ RV + YA L+EST EY+ QR C+ ++GG +DSKGYG+ TP GS R+ Sbjct: 173 NSDEGIQRVLTT--DYALLMESTSIEYVTQRN-CNLTQIGGLIDSKGYGVGTPIGSPYRD 229 Query: 766 AVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGG 798 + +A+L+L E+G L +K KWW G C G Sbjct: 230 KITIAILQLQEEGKLHMMKEKWWRGNG-CPEEG 261 Score = 202 bits (514), Expect = 5e-52, Method: Composition-based stats. Identities = 85/199 (42%), Positives = 118/199 (59%), Gaps = 7/199 (3%) Query: 410 GLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDG 469 L N+T++VTTILE PYVM +K+ + L GN+R+EGYC+DL E++ GF Y + +V DG Sbjct: 1 SLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDG 60 Query: 470 KYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ 529 KYGA++ D WNGMV EL+ +AD+A+APLTIT VRE+VIDFSKPFM+LGISI+ +K Sbjct: 61 KYGAQN-DKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKG- 118 Query: 530 KSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSEST 589 D LA + + G ++ F S+ S YE F R+ + Sbjct: 119 ----TPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYE-KMWAFMSSRQQTALVRN 173 Query: 590 NEFGIFNSLWFSLGAFMQQ 608 ++ GI L M+ Sbjct: 174 SDEGIQRVLTTDYALLMES 192 >5EHM-A nrPDB Length = 268 Score = 203 bits (516), Expect = 3e-52, Method: Composition-based stats. Identities = 82/152 (53%), Positives = 103/152 (67%), Gaps = 4/152 (2%) Query: 646 TVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVR 705 + R +PIESAEDL+KQT I YG L GST FFR SKI+ + +MW++M SA PSVF Sbjct: 117 ILYRKGTPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFTA 176 Query: 706 TTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRN 765 + EGV RV K KG YA+L+EST EY+ +R C+ +VGG LD+K YGIATP S R Sbjct: 177 SNGEGVERVAKGKGSYAFLMESTSIEYVTERN-CELTQVGGMLDTKSYGIATPPNSPYRT 235 Query: 766 AVNLAVLKLNEQGLLDKLKNKWWYDK---GEC 794 A+N +LKL E+G L LK KWW +K G+C Sbjct: 236 AINSVILKLQEEGKLHILKTKWWKEKRGGGKC 267 Score = 186 bits (471), Expect = 5e-47, Method: Composition-based stats. Identities = 73/187 (39%), Positives = 109/187 (58%), Gaps = 6/187 (3%) Query: 408 TSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVG 467 ++ L+NKT+VVTTIL +PY M K++ L GN+++EGY VDL EI+K GF YK+ +V Sbjct: 2 SANLKNKTLVVTTILSNPYCMRKESAIPLSGNDQFEGYAVDLIHEISKSLGFNYKIQLVP 61 Query: 468 DGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKK 527 DG YG+ + T WNGM+ EL+ +AD+AIA LTIT RE+ +DF+ PFM+LG+SI+ +K Sbjct: 62 DGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSILYRK 121 Query: 528 PQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSE 587 + LA + + G + F S+ S Y+ F + Sbjct: 122 G-----TPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQ-RMWSFMESARPSVFT 175 Query: 588 STNEFGI 594 ++N G+ Sbjct: 176 ASNGEGV 182 >4IGR-A nrPDB Length = 258 Score = 202 bits (513), Expect = 7e-52, Method: Composition-based stats. Identities = 69/150 (46%), Positives = 98/150 (65%), Gaps = 5/150 (3%) Query: 646 TVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVR 705 + R +PI+SA+DL+KQT+I YG + G+T FF++SKI+ F+KMW +M S +PS V+ Sbjct: 114 ILYRKGTPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSS-KPSALVK 172 Query: 706 TTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRN 765 EG+ R + YA L+EST EYI QR C+ ++GG +DSKGYGI TP GS R+ Sbjct: 173 NNEEGIQRTLTA--DYALLMESTTIEYITQRN-CNLTQIGGLIDSKGYGIGTPMGSPYRD 229 Query: 766 AVNLAVLKLNEQGLLDKLKNKWWYDKGECG 795 + +A+L+L E+ L +K KWW G C Sbjct: 230 KITIAILQLQEEDKLHIMKEKWWRGSG-CP 258 Score = 199 bits (505), Expect = 5e-51, Method: Composition-based stats. Identities = 82/196 (41%), Positives = 116/196 (59%), Gaps = 8/196 (4%) Query: 413 NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYG 472 N++++VTT+LE P+VM +K+ L GN+R+EGYC+DL E+A GF Y++ +V DGKYG Sbjct: 5 NRSLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYG 64 Query: 473 ARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSK 532 A+D D WNGMV EL+ KAD+A+APLTIT VRE+ IDFSKPFM+LG+SI+ +K Sbjct: 65 AQD-DKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKG---- 119 Query: 533 PGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEF 592 D LA + + G ++ F S+ S +E F + + NE Sbjct: 120 -TPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFE-KMWAFMSSK-PSALVKNNEE 176 Query: 593 GIFNSLWFSLGAFMQQ 608 GI +L M+ Sbjct: 177 GIQRTLTADYALLMES 192 >5IKB-A nrPDB Length = 257 Score = 200 bits (508), Expect = 2e-51, Method: Composition-based stats. Identities = 75/150 (50%), Positives = 101/150 (67%), Gaps = 4/150 (2%) Query: 646 TVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVR 705 + R +PIES +DL+ QT I YGT+ GS+ FF+ S+ + +MW YM S +PSVFV+ Sbjct: 112 ILYRKGTPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVK 171 Query: 706 TTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRN 765 +T EG+ARV S YA+LLESTMNEY QR C+ ++GG LD+KGYGI P GS R+ Sbjct: 172 STEEGIARVLNS--NYAFLLESTMNEYYRQRN-CNLTQIGGLLDTKGYGIGMPVGSVFRD 228 Query: 766 AVNLAVLKLNEQGLLDKLKNKWWYDKGECG 795 +LA+L+L E L+ LK KWW + G+C Sbjct: 229 EFDLAILQLQENNRLEILKRKWW-EGGKCP 257 Score = 195 bits (495), Expect = 7e-50, Method: Composition-based stats. Identities = 83/198 (41%), Positives = 119/198 (60%), Gaps = 7/198 (3%) Query: 413 NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYG 472 N T+VVTTILE+PY+M+K NH+ +EGN+RYEG+CVD+ E+A+ F YK+ +VGDG YG Sbjct: 3 NTTLVVTTILENPYLMLKGNHQDMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYG 62 Query: 473 ARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSK 532 +A+ W GMVGEL+ KAD+A+A LTIT RE+VIDFSKPFM+LGISI+ +K Sbjct: 63 VPEAN-GTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRKG---- 117 Query: 533 PGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEF 592 +D LA + + + G S+ F SR+ Y+ + ++ + E Sbjct: 118 -TPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQ-RMWNYMYSKQPSVFVKSTEE 175 Query: 593 GIFNSLWFSLGAFMQQGC 610 GI L + ++ Sbjct: 176 GIARVLNSNYAFLLESTM 193 >5DT6-A nrPDB Length = 267 Score = 195 bits (495), Expect = 8e-50, Method: Composition-based stats. Identities = 83/149 (55%), Positives = 108/149 (72%), Gaps = 1/149 (0%) Query: 646 TVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVR 705 + + +PI++ EDL+ QT++ YGTL GST EFFRRS+I + +KMW YM +A V Sbjct: 119 IMIKKGTPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-NANQHHSVH 177 Query: 706 TTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRN 765 T EG+ RVR+SKGKYA L+ES NEY+ R PCDTMKVG N+D+KG+G+ATP GS LR Sbjct: 178 TYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRK 237 Query: 766 AVNLAVLKLNEQGLLDKLKNKWWYDKGEC 794 +N AVL L E G L +++NKWW+DK EC Sbjct: 238 RLNEAVLTLKENGELLRIRNKWWFDKTEC 266 Score = 156 bits (395), Expect = 3e-38, Method: Composition-based stats. Identities = 78/190 (41%), Positives = 105/190 (55%), Gaps = 12/190 (6%) Query: 409 SGLENKTVVVTTILESPYVMMKKNH--EMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIV 466 S N T +V+++LE PY+ +K+ E L GN+R+EGYC DLA +A G KY++ +V Sbjct: 2 SYDRNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLV 61 Query: 467 GDGKYGARDADT-KIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMI 525 DG YGA + W+GMVGEL+ +ADIAI+ +TIT RE VIDFSKPFM+LGISIMI Sbjct: 62 QDGNYGAENQYAPGGWDGMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMI 121 Query: 526 KKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFE-DGRETQ 584 KK K + L + + G + F R S H + +E Sbjct: 122 KKGTPIKTP-----EDLTMQTDVNYGTLLYGSTWEFF---RRSQIGLHNKMWEYMNANQH 173 Query: 585 SSESTNEFGI 594 S T + GI Sbjct: 174 HSVHTYDEGI 183 >5CC2-A nrPDB Length = 265 Score = 172 bits (436), Expect = 6e-43, Method: Composition-based stats. Identities = 50/158 (31%), Positives = 82/158 (51%), Gaps = 10/158 (6%) Query: 646 TVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDK------MWTYM-RSA 698 + R + I+S +DLSKQT+I YGT+ + + R + F++ MW + RS Sbjct: 109 VLLRRGTSIQSLQDLSKQTDIPYGTVLDSAVYQHVRMKGLNPFERDSMYSQMWRMINRSN 168 Query: 699 EPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKP-CDTMKVGGNLDSKGYGIAT 757 V + G+ +V+ G YA++ ++ + EY+ P C VG + +GYGIA Sbjct: 169 GSENNVLESQAGIQKVKY--GNYAFVWDAAVLEYVAINDPDCSFYTVGNTVADRGYGIAL 226 Query: 758 PKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECG 795 GS R+ + +L+L + G +D LK+KWW G+C Sbjct: 227 QHGSPYRDVFSQRILELQQSGDMDILKHKWWPKNGQCD 264 Score = 137 bits (344), Expect = 2e-32, Method: Composition-based stats. Identities = 46/159 (28%), Positives = 84/159 (52%), Gaps = 8/159 (5%) Query: 413 NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYG 472 + V T+LE P+VM+ +N +L ++Y+G+ +D+ ++ + GF Y++ + D KYG Sbjct: 2 GVVLRVVTVLEEPFVMVSEN--VLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYG 59 Query: 473 ARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSK 532 + D WNG+VGELV+ +ADI I+ LTIT RE V+DF+ +M + +++++ Sbjct: 60 SPQED-GTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLRRG---- 114 Query: 533 PGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYE 571 L L+ + + + +P+E Sbjct: 115 -TSIQSLQDLSKQTDIPYGTVLDSAVYQHVRMKGLNPFE 152 >4WXJ-A nrPDB Length = 269 Score = 171 bits (432), Expect = 2e-42, Method: Composition-based stats. Identities = 51/146 (34%), Positives = 81/146 (55%), Gaps = 1/146 (0%) Query: 646 TVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVR 705 + + I S DL Q ++ +GT+ G+T +F S W M S +P F + Sbjct: 120 ILSYKGTDIGSLHDLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTK 179 Query: 706 TTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRN 765 EGV RV+ SKG YA+L+E+T +Y QR C+ ++G + K YGIA P + R+ Sbjct: 180 NNEEGVDRVKLSKGTYAFLMETTNLQYYVQRN-CELTQIGESFGEKHYGIAVPLNADFRS 238 Query: 766 AVNLAVLKLNEQGLLDKLKNKWWYDK 791 +++ +L+L+E+G L KL+NKW+ Sbjct: 239 NLSVGILRLSERGELFKLRNKWFNSN 264 Score = 142 bits (357), Expect = 7e-34, Method: Composition-based stats. Identities = 56/154 (36%), Positives = 77/154 (50%), Gaps = 7/154 (4%) Query: 415 TVVVTTILESPYVMMKKNHEML--EGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYG 472 V T + PY ++ E + EGNER+EGY VDL +A+ C F + V D KYG Sbjct: 10 RYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYG 69 Query: 473 ARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSK 532 + DA+T W+G++ +L+ A I I LTIT R V+DF+ PFM LGISI+ K Sbjct: 70 SYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKGTDIG 129 Query: 533 PGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSR 566 L L + + G + V F S Sbjct: 130 S-----LHDLVDQNKVQFGTIRGGATSVYFSESN 158 >5I2K-B nrPDB Length = 293 Score = 160 bits (404), Expect = 3e-39, Method: Composition-based stats. Identities = 38/147 (25%), Positives = 66/147 (44%), Gaps = 9/147 (6%) Query: 650 MVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAE 709 ++ I + + Y T+ S +FRR M+ +M + AE Sbjct: 156 RITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQ--VELSTMYRHMEKHN----YESAAE 209 Query: 710 GVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNL 769 + VR +K +A++ +S + E+ E + CD + G G+GI K S + V+L Sbjct: 210 AIQAVRDNK-LHAFIWDSAVLEF-EASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSL 267 Query: 770 AVLKLNEQGLLDKLKNKWWYDKGECGS 796 ++LK +E G ++ L +K W EC S Sbjct: 268 SILKSHENGFMEDL-DKTWVRYQECDS 293 Score = 132 bits (333), Expect = 4e-31, Method: Composition-based stats. Identities = 46/154 (29%), Positives = 77/154 (50%), Gaps = 35/154 (22%) Query: 410 GLENKTVVVTTILESPYVMMKKNHEMLEGNERYE-------------------------- 443 G + + + TI + P+V +K E + Sbjct: 1 GSMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTV 60 Query: 444 -----GYCVDLAAEIAKHCGFKYKLTIVGDGKYGAR----DADTKIWNGMVGELVYGKAD 494 G+C+DL ++A+ F Y++ +V DGK+G + +++ K WNGM+GEL+ G+AD Sbjct: 61 PQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQAD 120 Query: 495 IAIAPLTITLVREEVIDFSKPFMSLGISIMIKKP 528 + +APLTI R + I+FSKPF G++I++KK Sbjct: 121 MIVAPLTINNERAQYIEFSKPFKYQGLTILVKKG 154 >4YKP-A nrPDB Length = 256 Score = 153 bits (387), Expect = 2e-37, Method: Composition-based stats. Identities = 44/161 (27%), Positives = 76/161 (47%), Gaps = 3/161 (1%) Query: 408 TSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVG 467 + L + + + ++ E P++ E EGN+ + G D+ ++++ GF Y+ Sbjct: 2 SKNLIGRHLRLGSVEEQPFMFF--ATEGCEGNDCWSGMVNDMVVKLSEDLGFTYEYIQPD 59 Query: 468 DGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKK 527 D K+GA + T WNGM+ +L+ K D+ L+ R+ ID+S PFM GI ++K Sbjct: 60 DRKFGALNKTTNEWNGMIRDLLDDKTDMIAIDLSTNSARKSAIDYSFPFMDAGIKAVVKG 119 Query: 528 PQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFS 568 + V LD Y+ W I + + SR+S Sbjct: 120 EGTTLNQVLELLDQDKYK-WGVIGSRHPETLLKTHRDSRYS 159 Score = 73.7 bits (179), Expect = 4e-13, Method: Composition-based stats. Identities = 27/149 (18%), Positives = 58/149 (38%), Gaps = 9/149 (6%) Query: 646 TVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVR 705 V+ + + +L Q + +G + S + + + + + ++ + V ++ Sbjct: 116 VVKGEGTTLNQVLELLDQDKYKWGVIGSRHPETLLKTHRDSRYSRL------VDEGVELK 169 Query: 706 TTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRN 765 + +R G + ++ E + + CD VG S Y PK S ++ Sbjct: 170 DLNHAIETLR--GGLFVFIDEGPVLAHNLIS-DCDVFSVGEEFQSFEYAFGLPKDSPYKS 226 Query: 766 AVNLAVLKLNEQGLLDKLKNKWWYDKGEC 794 ++ +LK E+G +D L KW C Sbjct: 227 LIDSHLLKFREEGFIDILWEKWSSGNSVC 255 >5H8N-A nrPDB Length = 285 Score = 148 bits (374), Expect = 8e-36, Method: Composition-based stats. Identities = 35/156 (22%), Positives = 64/156 (41%), Gaps = 20/156 (12%) Query: 650 MVSPIESAEDLSKQ------TEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVF 703 + + D Q +GT+ +GST+ R + + M YM F Sbjct: 141 RGTQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNN----YPYMHQYMTK-----F 191 Query: 704 VRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR-KPCDTMKVGGN--LDSKGYGIATPKG 760 + E K+ A++ ++ + Y R + C + +G + GYGIA KG Sbjct: 192 NQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKG 251 Query: 761 SSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGS 796 S + ++LA+L+ G +++L+ W G C + Sbjct: 252 SPWKRQIDLALLQFVGDGEMEELETLWL--TGICHN 285 Score = 145 bits (366), Expect = 8e-35, Method: Composition-based stats. Identities = 55/198 (27%), Positives = 97/198 (48%), Gaps = 7/198 (3%) Query: 387 GYWSEVDKMVVTLTELP--SGNDTSGLENKTVVVTTILESPYVMMKKN-HEMLEGNERYE 443 G + +VTL E P D L +T V T+ +V + + +E + + + Sbjct: 1 GSPDDNHLSIVTLEEAPFVIVEDIDPL-TETCVRNTVPCRKFVKINNSTNEGMNVKKCCK 59 Query: 444 GYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTIT 503 G+C+D+ ++++ F Y L +V +GK+G + + +WNGM+GE+VY +A +A+ LTI Sbjct: 60 GFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNN--VWNGMIGEVVYQRAVMAVGSLTIN 117 Query: 504 LVREEVIDFSKPFMSLGISIMIKKP-QKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF 562 R EV+DFS PF+ GIS+M+ + Q + F P Y G + Sbjct: 118 EERSEVVDFSVPFVETGISVMVSRGTQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNI 177 Query: 563 LVSRFSPYEWHTEEFEDG 580 + +++ T+ + G Sbjct: 178 RNNYPYMHQYMTKFNQKG 195 >2RC9-A nrPDB Length = 294 Score = 148 bits (372), Expect = 1e-35, Method: Composition-based stats. Identities = 37/156 (23%), Positives = 66/156 (42%), Gaps = 14/156 (8%) Query: 645 LTVERMVSPIESAEDLS---KQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPS 701 + V + + D +GT+ S +++ R+S F +M YMR Sbjct: 147 ILVRTRGTELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQS----FPEMHEYMRRYN-- 200 Query: 702 VFVRTTAEGVARVRKSKGKY-AYLLESTMNEY-IEQRKPCDTMKVGGNLDSKGYGIATPK 759 V T +GV ++ K A++++ + +Y + C + VG +GYGI P Sbjct: 201 --VPATPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPP 258 Query: 760 GSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECG 795 S L + ++ + + G +D L +KW Y CG Sbjct: 259 NSPLTSNISELISQYKSHGFMDVLHDKW-YKVVPCG 293 Score = 116 bits (290), Expect = 5e-26, Method: Composition-based stats. Identities = 42/161 (26%), Positives = 71/161 (44%), Gaps = 37/161 (22%) Query: 410 GLENKTVVVTTILESPYVMMKKNHE----------------------------------- 434 G + V T++E P+V ++ + Sbjct: 1 GSNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSMLDRLFSSLHSSNDTV 60 Query: 435 MLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKAD 494 ++ + GYC+DL ++A+ F + L IVGDGKYGA W G+VG+L+ G A+ Sbjct: 61 PIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGA--WKNGHWTGLVGDLLSGTAN 118 Query: 495 IAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGV 535 +A+ +I R +VIDF+ PF S + I+++ G+ Sbjct: 119 MAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRGTELSGI 159 >2RCB-A nrPDB Length = 292 Score = 142 bits (358), Expect = 6e-34, Method: Composition-based stats. Identities = 36/156 (23%), Positives = 65/156 (41%), Gaps = 14/156 (8%) Query: 645 LTVERMVSPIESAEDLS---KQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPS 701 + V + + D +GT+ S + + + S F +M +MR Sbjct: 145 IMVRTRGTELSGIHDPKLHHPSQGFRFGTVWESSAEAYIKAS----FPEMHAHMRRHS-- 198 Query: 702 VFVRTTAEGVARVRKSKGKY-AYLLESTMNEY-IEQRKPCDTMKVGGNLDSKGYGIATPK 759 TT GVA + K A++++ ++ +Y + C + VG +GYGI P+ Sbjct: 199 --APTTPHGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQ 256 Query: 760 GSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECG 795 S L + ++ + + G +D L +KW Y CG Sbjct: 257 NSPLTSNLSEFISRYKSSGFIDLLHDKW-YKMVPCG 291 Score = 118 bits (296), Expect = 1e-26, Method: Composition-based stats. Identities = 61/288 (21%), Positives = 103/288 (35%), Gaps = 52/288 (18%) Query: 415 TVVVTTILESPYVMMKKNHEMLEGN---------------------------------ER 441 + V T++E P+V +++ E + Sbjct: 6 KLRVVTLVEHPFVFTRESDEDGQCPAGQLCLDPGTNDSARLDALFAALVNGSVPRTLRRC 65 Query: 442 YEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLT 501 GYC+DL +A+ F ++L IVGDGKYGA W G+VG+L+ G+A +A+ + Sbjct: 66 CYGYCIDLLERLAEDLAFDFELYIVGDGKYGAL--RDGRWTGLVGDLLAGRAHMAVTSFS 123 Query: 502 ITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDP--LAYEIWMCIVFAYIGVSV 559 I R +V+DF+ PF S + IM++ G+ DP + + Sbjct: 124 INSARSQVVDFTSPFFSTSLGIMVRTRGTELSGIH---DPKLHHPSQGFRFGTVWESSAE 180 Query: 560 VLFLVSRFSPYEWHTEEFEDGRETQS-------SESTNEFGIFNSLWFSLGAFMQQGCDI 612 ++ + F H N F + SL + C + Sbjct: 181 A-YIKASFPEMHAHMRRHSAPTTPHGVAMLTSDPPKLNAFIMDKSL-LDYEVSIDADCKL 238 Query: 613 SPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL 660 I G + L S T+NL+ F++ + I+ D Sbjct: 239 LTVGKPFAIEG---YGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDK 283 >3OEK-A nrPDB Length = 286 Score = 133 bits (335), Expect = 3e-31, Method: Composition-based stats. Identities = 56/253 (22%), Positives = 101/253 (39%), Gaps = 35/253 (13%) Query: 410 GLENKTVVVTTILESPYVMMKKNH--------------------------EMLEGNERYE 443 G + + + V T+ E P+V+++ + Sbjct: 1 GDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCK 60 Query: 444 GYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTIT 503 G+C+D+ +A GF Y L +V +GK+G + +WNGM+GE+ Y +AD+AI LTI Sbjct: 61 GFCIDILKRLAHTIGFSYDLYLVTNGKHGKKID--GVWNGMIGEVFYQRADMAIGSLTIN 118 Query: 504 LVREEVIDFSKPFMSLGISIMIKKPQK-SKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF 562 R E++DFS PF+ GIS+M+ + S F P + G + Sbjct: 119 EERSEIVDFSVPFVETGISVMVARGTTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNI 178 Query: 563 LVSRFS----PYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLS 618 + ++ E+ + + F I+++ + A +GC + S Sbjct: 179 RSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAF-IYDAAVLNYMARKDEGCKLVTIG-S 236 Query: 619 GRIVGGVWWFFTL 631 G++ + L Sbjct: 237 GKVFATTGYGIAL 249 Score = 129 bits (325), Expect = 4e-30, Method: Composition-based stats. Identities = 32/156 (20%), Positives = 67/156 (42%), Gaps = 20/156 (12%) Query: 650 MVSPIESAEDLSKQ------TEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVF 703 + + D Q + +GT+ +GST++ R + + M +YM Sbjct: 142 RGTTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSN----YPDMHSYMVRYNQ--- 194 Query: 704 VRTTAEGVARVRKSKGKYAYLLESTMNEYIE-QRKPCDTMKVGGN--LDSKGYGIATPKG 760 E + +++ K A++ ++ + Y+ + + C + +G + GYGIA KG Sbjct: 195 -PRVEEALTQLKAGK-LDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKG 252 Query: 761 SSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGS 796 S + ++LA+L+ ++ L+ W G C + Sbjct: 253 SRWKRPIDLALLQFLGDDEIEMLERLWL--SGICHN 286 >5TUJ-C nrPDB Length = 235 Score = 129 bits (324), Expect = 5e-30, Method: Composition-based stats. Identities = 40/170 (23%), Positives = 76/170 (44%), Gaps = 21/170 (12%) Query: 411 LENKTVVVTTI-LESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDG 469 ++ T+ V T P+ + N +Y G+ +DLA +AK G K + Sbjct: 9 MKRGTLRVGTDADYKPF-------SFKDKNGQYTGFDIDLAKALAKELGVKVEFVPT--- 58 Query: 470 KYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ 529 W+G++ L GK DI ++ +TIT R++ +DFS P+M+ G +I++KK Sbjct: 59 ----------TWDGIIPALQTGKFDIVMSGMTITPERKKKVDFSDPYMTAGQTILVKKDN 108 Query: 530 KSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFED 579 K F L+ ++ + + + ++ +E + E F++ Sbjct: 109 ADKIKSFEDLNKPDVKVAVQLGTTSEQAAKEFLPKAKIRTFENNAEAFQE 158 Score = 51.3 bits (121), Expect = 2e-06, Method: Composition-based stats. Identities = 38/150 (25%), Positives = 58/150 (38%), Gaps = 22/150 (14%) Query: 645 LTVERMVSPIESAEDLSKQT---EIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPS 701 L + I+S EDL+K + GT + KEF ++KI F+ Sbjct: 103 LVKKDNADKIKSFEDLNKPDVKVAVQLGTTSEQAAKEFLPKAKIRTFE------------ 150 Query: 702 VFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKP-CDTMKVGGNLDSKGYGIATPKG 760 AE V S A + +S + Y ++ P + V + G A KG Sbjct: 151 ----NNAEAFQEVV-SGRADAMVTDSPVAAYYAKKNPGLAVVVVDEPFTHEPLGFAIRKG 205 Query: 761 SS-LRNAVNLAVLKLNEQGLLDKLKNKWWY 789 L N VN + ++ + G DKL KW+ Sbjct: 206 DPELLNWVNNWLKQMKKDGTYDKLYEKWFK 235 >4G4P-A nrPDB Length = 244 Score = 128 bits (321), Expect = 1e-29, Method: Composition-based stats. Identities = 42/172 (24%), Positives = 70/172 (40%), Gaps = 29/172 (16%) Query: 410 GLENKTVVVTTILE-SPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGD 468 G+E K + T L +P+ E + +Y G VDL IAK F+ L +G Sbjct: 19 GMEGKKYTIGTDLTFAPF-------EFQDSKGKYIGIDVDLLDAIAKDQDFEVDLKPLG- 70 Query: 469 GKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKP 528 ++ V + + D IA ++IT R++ DFS P+ G+ + +KK Sbjct: 71 ------------FDSAVQAIQSKQIDGMIAGMSITDERKKSFDFSDPYFDSGLQLAVKKG 118 Query: 529 QKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDG 580 + S+ D + V A +G FL Y++ + F+D Sbjct: 119 ND---KIKSYDD-----LKGKTVAAKVGTESANFLEKNKEKYDYTIKNFDDA 162 >4ZDM-A nrPDB Length = 261 Score = 123 bits (309), Expect = 3e-28, Method: Composition-based stats. Identities = 32/144 (22%), Positives = 63/144 (43%), Gaps = 2/144 (1%) Query: 408 TSGLENKTVVVTTILESPYVMMKK-NHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIV 466 ++ L + + I E P++ + Y G V++ + +++ F Y Sbjct: 2 SNNLNGMHLRLGIIPEMPFISEPSLGCTNIRDPSCYTGVNVEIVSMMSQDLNFTYNFITP 61 Query: 467 GDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIK 526 D K+G +++ T WNG++ +L+ K D+ + L+ VR+ IDFS M G+ ++K Sbjct: 62 EDLKFGGKNSTTGEWNGLIRDLLDNKTDMIVVALSNNAVRKADIDFSLSMMDGGLGALVK 121 Query: 527 KPQKSKPGVFSFLDPLAYEIWMCI 550 L+ Y+ W + Sbjct: 122 SDGTDLSHPLELLNQDKYQ-WGVV 144 Score = 64.0 bits (154), Expect = 3e-10, Method: Composition-based stats. Identities = 31/142 (21%), Positives = 66/142 (46%), Gaps = 9/142 (6%) Query: 646 TVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVR 705 V+ + + +L Q + +G +DS + + ++ A ++++ AE +V V Sbjct: 119 LVKSDGTDLSHPLELLNQDKYQWGVVDSRNPELLLASNQNADYNRI------AEDAVKVG 172 Query: 706 TTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRN 765 + EG+ R+R G + ++ E Y + + CD +++G K S +N Sbjct: 173 SYGEGLERMR--AGGFVFIDEIPGINYATKGE-CDIVQIGETFQPFELAFGLRKNSPFKN 229 Query: 766 AVNLAVLKLNEQGLLDKLKNKW 787 V+ +L + EQG++ +L K+ Sbjct: 230 LVDTFMLGIREQGVISELYAKY 251 >4ZV2-A nrPDB Length = 233 Score = 110 bits (274), Expect = 3e-24, Method: Composition-based stats. Identities = 39/168 (23%), Positives = 69/168 (41%), Gaps = 27/168 (16%) Query: 415 TVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGAR 474 T+ V T P K + N + G+ +DLA IAK G K + + Sbjct: 11 TLRVGTEATFPPFGFK------DENGKLVGFDIDLAKAIAKKLGVKVEFKPMD------- 57 Query: 475 DADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPG 534 ++G++ L GK D+ IA +TIT R++ +DFS P+ G +I++KK S Sbjct: 58 ------FDGIIPALQSGKIDVVIAGMTITEERKKQVDFSDPYFEAGQAIVVKKGNDSIKS 111 Query: 535 VFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRE 582 + ++ V +G + + ++F++ E Sbjct: 112 L--------EDLKGKKVGVQLGSTSEQHVKKVAKDAGVKVKKFDNFSE 151 Score = 52.9 bits (125), Expect = 6e-07, Method: Composition-based stats. Identities = 32/146 (21%), Positives = 59/146 (40%), Gaps = 16/146 (10%) Query: 645 LTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFV 704 + V++ I+S EDL + G ++++ ++ K+ + F Sbjct: 100 IVVKKGNDSIKSLEDLKGK---KVGVQLGSTSEQHVKKVAKDAGVKVKKF------DNFS 150 Query: 705 RTTAEGVARVRKSKGKYAYLLESTM-NEYIEQRKPCDTMKVGGNLDSKGYGIATPKG-SS 762 E KS A + ++ + Y++Q VG + YGIA KG S Sbjct: 151 EAFQE-----LKSGRVDAVVTDNAVALAYVKQNPNAGVKIVGETFSGEPYGIAVRKGNSE 205 Query: 763 LRNAVNLAVLKLNEQGLLDKLKNKWW 788 L +N A+ ++ + G DK+ KW+ Sbjct: 206 LLEKINKALEEMKKDGTYDKIYEKWF 231 >4PSH-A nrPDB Length = 227 Score = 108 bits (269), Expect = 1e-23, Method: Composition-based stats. Identities = 36/148 (24%), Positives = 63/148 (42%), Gaps = 13/148 (8%) Query: 434 EMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKA 493 E ++ N G+ VDLA EIA+ G + K+ ++G++ L+ K Sbjct: 23 EFVDENGNIVGFDVDLAKEIARRLGVELKIV-------------DMTFDGLIPSLLTKKI 69 Query: 494 DIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFA 553 D+ I+ +TIT R++V+ FS P+ G I+++K +P + L + + Sbjct: 70 DVIISGMTITEERKKVVAFSDPYFDAGQVIVVRKDSDFRPKTYEDLVGKTVAVQIGTTGD 129 Query: 554 YIGVSVVLFLVSRFSPYEWHTEEFEDGR 581 V RF + E + GR Sbjct: 130 IEVSKYDGIKVVRFDKFTDAFLELKRGR 157 Score = 35.9 bits (81), Expect = 0.086, Method: Composition-based stats. Identities = 24/93 (25%), Positives = 38/93 (40%), Gaps = 12/93 (12%) Query: 709 EGVARVRKSKGKYAYL-----------LESTMNEYIEQRKPCDTMKVGGNLDSKGYGIAT 757 +G+ VR K A+L L+S + P D + G L S+ YGIA Sbjct: 136 DGIKVVRFDKFTDAFLELKRGRADAVVLDSATARAFVAKNP-DLVISSGVLSSEQYGIAV 194 Query: 758 PKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYD 790 K + +VL+ ++ D L KW+ + Sbjct: 195 RKEDTDLLEFINSVLRELKKSPYDVLIEKWFSE 227 >4ZEF-A nrPDB Length = 251 Score = 106 bits (264), Expect = 5e-23, Method: Composition-based stats. Identities = 39/163 (23%), Positives = 62/163 (38%), Gaps = 25/163 (15%) Query: 420 TILESPYVMMKKNH----EMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARD 475 T + YV+ + E Y G VDL A+ GF + +G Sbjct: 24 TPKKEKYVIASDSTFAPFEFQNAQGDYVGIDVDLVKRAAELQGFTVEFKFIG-------- 75 Query: 476 ADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGV 535 ++ V + G+AD +A +TIT R++ DFS P+ GI I +KK + Sbjct: 76 -----FSSAVQAVESGQADGMVAGMTITDDRKKAFDFSVPYFDSGIQIAVKKGND---KI 127 Query: 536 FSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFE 578 S+ D + V IG FL Y++ + + Sbjct: 128 KSYDD-----LKGKKVGVKIGTESADFLEKNKKKYDYSIKYLD 165 >4F3P-A nrPDB Length = 249 Score = 104 bits (258), Expect = 2e-22, Method: Composition-based stats. Identities = 36/162 (22%), Positives = 71/162 (43%), Gaps = 29/162 (17%) Query: 410 GLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDG 469 + + VV T P+ E +G ++Y G+ +DL AEIAK G+ YK+ + Sbjct: 21 SMAKELVVGTDTSFMPF-------EFKQG-DKYVGFDLDLWAEIAKGAGWTYKIQPMD-- 70 Query: 470 KYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ 529 + G++ L D+A++ +TI R + IDFS P+ G++ M++ Sbjct: 71 -----------FAGLIPALQTQNIDVALSGMTIKEERRKAIDFSDPYYDSGLAAMVQANN 119 Query: 530 KSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYE 571 + + ++ ++ A G + + ++ + P E Sbjct: 120 TTIKSID--------DLNGKVIAAKTGTATIDWIKAHLKPKE 153 Score = 45.9 bits (107), Expect = 7e-05, Method: Composition-based stats. Identities = 33/154 (21%), Positives = 56/154 (36%), Gaps = 21/154 (13%) Query: 637 YTANLAAFLTVERMVSPIESAEDLS-KQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYM 695 Y + LAA V+ + I+S +DL+ K GT K + +I F Sbjct: 107 YDSGLAA--MVQANNTTIKSIDDLNGKVIAAKTGTATIDWIKAHLKPKEIRQFP------ 158 Query: 696 RSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKV-GGNLDSKGYG 754 + ++ A + ++ + + +KV G + YG Sbjct: 159 -----------NIDQAYLALEAGRVDAAMHDTPNVLFFVNNEGKGRVKVAGAPVSGDKYG 207 Query: 755 IATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWW 788 I PKGS L VN + ++ G K+ KW+ Sbjct: 208 IGFPKGSPLVAKVNAELARMKADGRYAKIYKKWF 241 >5JOS-A nrPDB Length = 247 Score = 102 bits (253), Expect = 9e-22, Method: Composition-based stats. Identities = 34/170 (20%), Positives = 70/170 (41%), Gaps = 21/170 (12%) Query: 411 LENKTVVVTTI-LESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDG 469 +E T+ V T P+ + + +Y G+ +D+A +AK G K + Sbjct: 20 MERGTLRVGTTGDYKPF-------SYRDPDGQYTGFDIDVAKSLAKSLGVKVEFVPT--- 69 Query: 470 KYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ 529 W ++ +L K DIA+ +T+T R++ DFS P+M+ G + +++K Sbjct: 70 ----------TWPTLMSDLQADKFDIAMGGVTVTPERQKKADFSDPYMTFGKTPLVRKED 119 Query: 530 KSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFED 579 K ++ + + + ++ + YE + E F++ Sbjct: 120 ADKFKSLEDINRPDVRVAVNPGGTNEKFAREHLKKAKITVYENNVEIFQE 169 >1GGG-A nrPDB Length = 226 Score = 102 bits (253), Expect = 9e-22, Method: Composition-based stats. Identities = 38/160 (23%), Positives = 64/160 (40%), Gaps = 29/160 (18%) Query: 412 ENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKY 471 + K VV T P+ E +G + Y G+ VDL A IAK Y+L + Sbjct: 2 DKKLVVATDTAFVPF-------EFKQG-DLYVGFDVDLWAAIAKELKLDYELKPMD---- 49 Query: 472 GARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKS 531 ++G++ L D+A+A +TIT R++ IDFS + G+ +M+K Sbjct: 50 ---------FSGIIPALQTKNVDLALAGITITDERKKAIDFSDGYYKSGLLVMVKANNND 100 Query: 532 KPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYE 571 V ++ +V G V + + + Sbjct: 101 VKSV--------KDLDGKVVAVKSGTGSVDYAKANIKTKD 132 Score = 43.6 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 24/70 (34%), Positives = 37/70 (52%), Gaps = 2/70 (2%) Query: 721 YAYLLESTMNEYIEQRKP-CDTMKVGGNLDSKGYGIATPKGSS-LRNAVNLAVLKLNEQG 778 A L ++ Y + VG +L+++ YGIA PKGS LR+ VN A+ L E G Sbjct: 152 DAVLHDTPNILYFIKTAGNGQFKAVGDSLEAQQYGIAFPKGSDELRDKVNGALKTLRENG 211 Query: 779 LLDKLKNKWW 788 +++ KW+ Sbjct: 212 TYNEIYKKWF 221 >3K4U-A nrPDB Length = 245 Score = 101 bits (250), Expect = 2e-21, Method: Composition-based stats. Identities = 37/146 (25%), Positives = 65/146 (44%), Gaps = 13/146 (8%) Query: 434 EMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKA 493 EM + G+ VDLA E+AK G K KL W+G++ LV K Sbjct: 19 EMKDKKGNVIGFDVDLAREMAKAMGVKLKLVPTS-------------WDGLIPGLVTEKF 65 Query: 494 DIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFA 553 DI I+ +TI+ R ++F +P++ +G S+++KK + + LD + + Sbjct: 66 DIIISGMTISQERNLRVNFVEPYIVVGQSLLVKKGLEKGVKSYKDLDKPELTLVTKFGVS 125 Query: 554 YIGVSVVLFLVSRFSPYEWHTEEFED 579 + LF ++ Y+ E ++ Sbjct: 126 AEYAAKRLFKNAKLKTYDTEAEAVQE 151 Score = 40.2 bits (92), Expect = 0.004, Method: Composition-based stats. Identities = 31/164 (18%), Positives = 61/164 (37%), Gaps = 22/164 (13%) Query: 633 IISSYTANLAAFLTVERMVSPIESAEDLSKQT---EIAYGTLDSGSTKEFFRRSKIAVFD 689 + Y + L + + ++S +DL K +G + K F+ +K+ +D Sbjct: 84 FVEPYIVVGQSLLVKKGLEKGVKSYKDLDKPELTLVTKFGVSAEYAAKRLFKNAKLKTYD 143 Query: 690 KMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMN-EYIEQRKPCDTMKVGGNL 748 T AE V V K ++ + N ++ Q+ + + +L Sbjct: 144 ----------------TEAEAVQEVLNGKADM-FIFDLPFNVAFMAQKGQGYLVHLDTSL 186 Query: 749 DSKGYGIATPKGSS-LRNAVNLAVLKLNEQGLLDKLKNKWWYDK 791 + G A KG N +N + ++ G D+L +W+ D Sbjct: 187 TYEPLGWAIKKGDPDFLNWLNHFLAQIKHDGSYDELYERWFVDT 230 >4H5F-A nrPDB Length = 243 Score = 97.6 bits (241), Expect = 2e-20, Method: Composition-based stats. Identities = 33/129 (25%), Positives = 60/129 (46%), Gaps = 17/129 (13%) Query: 412 ENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKY 471 + K VV T+ +P+ +++G + G +D+A IA G K ++ + Sbjct: 11 KGKLVVATSPDYAPFEF----QSLVDGKNQVVGADIDMAQAIADELGVKLEILSMS---- 62 Query: 472 GARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKS 531 ++ ++ L GKAD+A+A ++ T R+EV DFS P+ IS ++ K Sbjct: 63 ---------FDNVLTSLQTGKADLAVAGISATDERKEVFDFSIPYYENKISFLVHKADVE 113 Query: 532 KPGVFSFLD 540 K + L+ Sbjct: 114 KYKDLTSLE 122 >4KQP-A nrPDB Length = 232 Score = 93.7 bits (231), Expect = 3e-19, Method: Composition-based stats. Identities = 34/153 (22%), Positives = 60/153 (39%), Gaps = 21/153 (13%) Query: 434 EMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKA 493 E ++++ G VDL IAK+ GFK K +G + V + G A Sbjct: 22 EFQNDDKQFTGIDVDLLNAIAKNQGFKLKWNFIG-------------FQAAVDSVQSGHA 68 Query: 494 DIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFA 553 D ++ ++IT R++V D+ P+ S ++I S ++ + A Sbjct: 69 DGMMSGMSITDARKQVFDYGSPYYSSNLTIATSSTDDSIKSW--------KDLKGKTLGA 120 Query: 554 YIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSS 586 G + +L + Y + + F D SS Sbjct: 121 KNGTASFDYLNAHAKEYGYTVKTFTDATTMYSS 153 >6FXG-A nrPDB Length = 227 Score = 91.0 bits (224), Expect = 2e-18, Method: Composition-based stats. Identities = 37/171 (21%), Positives = 68/171 (39%), Gaps = 29/171 (16%) Query: 410 GLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDG 469 G+E + + +P+ E G +++ G VD+ E+AK +K +++ G Sbjct: 1 GMETTVKIASDSSYAPF-------EFQNGQKKWVGIDVDIMQEVAKINDWKLEMSYPG-- 51 Query: 470 KYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ 529 ++ + L G+ D IA +TIT R+E DFS P+ + ++I K Sbjct: 52 -----------FDAALQNLKAGQVDGIIAGMTITDERKETFDFSNPYYTSALTIATTKDS 100 Query: 530 KSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDG 580 K ++ V A G + +L Y + + + DG Sbjct: 101 KLS---------DYSDLKGKAVGAKNGTAAQTWLQENQKKYGYTIKTYSDG 142 >4OEN-A nrPDB Length = 223 Score = 90.2 bits (222), Expect = 3e-18, Method: Composition-based stats. Identities = 33/167 (19%), Positives = 64/167 (38%), Gaps = 29/167 (17%) Query: 414 KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGA 473 K ++ + +P+V + +Y G ++L IAK GF+ ++ Sbjct: 4 KYIIASDSSFAPFV-------FQNSSNQYTGIDMELIKAIAKDQGFEIEI---------- 46 Query: 474 RDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKP 533 ++ + + G+AD IA +++T R+ DFS+ + + + +K + S Sbjct: 47 ---TNPGFDAAISAVQAGQADGIIAGMSVTDARKATFDFSESYYTANTILGVK--ESSNI 101 Query: 534 GVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDG 580 + L V G + FL S Y + + F DG Sbjct: 102 ASYEDL-------KGKTVGVKNGTASQTFLTENQSKYGYKIKTFADG 141 >4IO3-A nrPDB Length = 248 Score = 89.1 bits (219), Expect = 7e-18, Method: Composition-based stats. Identities = 35/155 (22%), Positives = 62/155 (40%), Gaps = 20/155 (12%) Query: 646 TVERMVSPIESAEDLSKQTEIAY---GTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSV 702 + R + I+ +DL K +I Y G + ++++ R S Sbjct: 109 ILMRKGTLIDGMDDL-KNGKIPYNRIGIRIGTAGEDYYLRE------------ISGGSRN 155 Query: 703 FV--RTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKG 760 F ++ E + ++ ++ EY+ C+ VG + D +GI TPK Sbjct: 156 FYPLKSRQEMYDSLLAGIIDVSF-MDIGTAEYVTNNIYCNLTLVGEDFDKSTFGIVTPKE 214 Query: 761 SSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECG 795 +++ +L L E G+LD LK KW+ K C Sbjct: 215 WLYAKDLDVNILSLRETGILDNLKKKWFQTKA-CP 248 Score = 65.6 bits (158), Expect = 1e-10, Method: Composition-based stats. Identities = 27/122 (22%), Positives = 51/122 (41%), Gaps = 10/122 (8%) Query: 408 TSGLENKTVVVTTILESPYVMMKKNHEMLEGNE-RYEGYCVDLAAEIAKHCGFKYKLTIV 466 ++ L+ T+ + I P+ ++ + N + GY +DL + GF + + Sbjct: 2 SARLKGITLRIGVIESVPFTIVANVIDTSGRNTTKLTGYVLDLIEYLRDKMGFVADVQLA 61 Query: 467 GDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIK 526 + G+V L G DIAI +T+T R E++ FS + I+++ Sbjct: 62 P---------PNTSYTGLVLALANGDYDIAIGDITVTSARREIVAFSNSISDNSMRILMR 112 Query: 527 KP 528 K Sbjct: 113 KG 114 >4KPT-A nrPDB Length = 251 Score = 89.1 bits (219), Expect = 8e-18, Method: Composition-based stats. Identities = 37/186 (19%), Positives = 70/186 (37%), Gaps = 29/186 (15%) Query: 395 MVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIA 454 M++ + E + + +P+ E G +++ G VD+ E+A Sbjct: 10 MMLATVTAFLVAPSVKAETTVKIASDSSYAPF-------EFQNGQKKWVGIDVDIMQEVA 62 Query: 455 KHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSK 514 K +K +++ G ++ + L G+ D IA +TIT R+E DFS Sbjct: 63 KINDWKLEMSYPG-------------FDAALQNLKAGQVDGIIAGMTITDERKETFDFSN 109 Query: 515 PFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHT 574 P+ + ++I K K ++ V A G + +L Y + Sbjct: 110 PYYTSALTIATTKDSKLS---------DYSDLKGKAVGAKNGTAAQTWLQENQKKYGYTI 160 Query: 575 EEFEDG 580 + + DG Sbjct: 161 KTYSDG 166 >4YMX-A nrPDB Length = 260 Score = 86.4 bits (212), Expect = 4e-17, Method: Composition-based stats. Identities = 34/156 (21%), Positives = 64/156 (41%), Gaps = 28/156 (17%) Query: 406 NDTSGLENKTVVV--TTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL 463 N ++ K V+V T+ P+ H++ G + G+ +D+A IAK G K ++ Sbjct: 28 NTVDQIKQKGVIVMGTSADFPPFEF----HKVEGGKDEIVGFDIDIANAIAKKLGVKLEI 83 Query: 464 TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISI 523 + + G++ L G+ D+ IA +T T R++ +DFS + + Sbjct: 84 KDMD-------------FKGLIPALQAGRVDMVIAGMTPTAERKKSVDFSDLYYDSRQVV 130 Query: 524 MIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSV 559 ++K S F L + + IG + Sbjct: 131 VVK--NDSPISKFDDL-------KVKTIAVQIGTTS 157 >4I62-A nrPDB Length = 269 Score = 86.0 bits (211), Expect = 6e-17, Method: Composition-based stats. Identities = 32/141 (22%), Positives = 66/141 (46%), Gaps = 22/141 (15%) Query: 404 SGNDTSGLE-----NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCG 458 S N ++G+E K VV +P+ + ++++G + G ++LA IA G Sbjct: 25 SNNQSAGIEAIKSKGKLVVALNPDFAPF----EYQKVVDGKNQIVGSDIELAKAIATELG 80 Query: 459 FKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMS 518 + +L+ + ++ ++ + GKAD+AI+ ++ T R +V DFS P+ + Sbjct: 81 VELELSPMS-------------FDNVLASVQSGKADLAISGVSKTDERSKVFDFSTPYYT 127 Query: 519 LGISIMIKKPQKSKPGVFSFL 539 +++KK + + L Sbjct: 128 AKNKLIVKKSDLATYQSVNDL 148 Score = 35.5 bits (80), Expect = 0.095, Method: Composition-based stats. Identities = 48/237 (20%), Positives = 92/237 (38%), Gaps = 31/237 (13%) Query: 559 VVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLS 618 +V+ L F+P+E+ ++ DG+ ++ + ++ LG ++SP S Sbjct: 41 LVVALNPDFAPFEY--QKVVDGKNQ---IVGSDIELAKAIATELGV----ELELSPMSFD 91 Query: 619 GRIVGGVWWFFTLIIISSYTANLAAFLTVER-----MVSPIESAEDL---SKQTEIAYGT 670 ++ V + IS + T ER +P +A++ K Y + Sbjct: 92 N-VLASVQSGKADLAISGVSK------TDERSKVFDFSTPYYTAKNKLIVKKSDLATYQS 144 Query: 671 LDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMN 730 ++ + K+ K ++ + M + V + + KS A + E + Sbjct: 145 VNDLAQKK-VGAQKGSIQETMAKDLLQNSSLVSLPKNGNLITD-LKSGQVDAVIFEEPVA 202 Query: 731 EYIEQRKPCDTMKVGGNLDSK---GYGIATPKGSS-LRNAVNLAVLKLNEQGLLDKL 783 + + P D N + + Y +A K S L+ AV+ + KL E G LDKL Sbjct: 203 KGFVENNP-DLAIADLNFEKEQDDSYAVAMKKDSKELKEAVDKTIQKLKESGELDKL 258 >2Q2A-A nrPDB Length = 272 Score = 84.1 bits (206), Expect = 3e-16, Method: Composition-based stats. Identities = 31/125 (24%), Positives = 53/125 (42%), Gaps = 21/125 (16%) Query: 412 ENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKY 471 + K VV T +P+ M+K + G+ VDL + K G Y+L +G Sbjct: 41 KKKVVVGTDAAFAPFEYMQK--------GKIVGFDVDLLDAVMKAAGLDYELKNIG---- 88 Query: 472 GARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKS 531 W+ + L + D+ I+ +TIT R++ DFS P+ I++K+ Sbjct: 89 ---------WDPLFASLQSKEVDMGISGITITDERKQSYDFSDPYFEATQVILVKQGSPV 139 Query: 532 KPGVF 536 K + Sbjct: 140 KNALD 144 Score = 48.6 bits (114), Expect = 1e-05, Method: Composition-based stats. Identities = 29/151 (19%), Positives = 62/151 (41%), Gaps = 20/151 (13%) Query: 642 AAFLTVERMVSPIESAEDLSKQT-EIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEP 700 A + + + SP+++A DL +T + T + ++ F + +++ E Sbjct: 127 ATQVILVKQGSPVKNALDLKGKTIGVQNATTGQEAAEKLFGKGP---------HIKKFET 177 Query: 701 SVFVRTTAEGVARVRKSKGKYAYLLESTM-NEYIEQRKPCDTMKVG--GNLDSKGYGIAT 757 +V + G A + ++ + NEY++ + N S+ YG+ Sbjct: 178 TVV-------AIMELLNGGVDAVITDNAVANEYVKNNPNKKLQVIEDPKNFASEYYGMIF 230 Query: 758 PKGSSLRNAVNLAVLKLNEQGLLDKLKNKWW 788 PK S L+ V+ A+ + G ++ KW+ Sbjct: 231 PKNSELKAKVDEALKNVINSGKYTEIYKKWF 261 >4F3S-A nrPDB Length = 255 Score = 82.9 bits (203), Expect = 5e-16, Method: Composition-based stats. Identities = 30/111 (27%), Positives = 53/111 (47%), Gaps = 23/111 (20%) Query: 409 SGLENKTVVVTTILESPYVMMKKNHEMLEGNER--YEGYCVDLAAEIAKHCGFKYKLTIV 466 S +E +T+ V SP ++ K L+G + + YC ++HC Sbjct: 4 SIVEGRTLNVAVSPASPPMLFKSADGKLQGIDLELFSSYCQ------SRHCKL------- 50 Query: 467 GDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFM 517 + W+GM+G + G+AD+A + ++IT R++VIDFS+P+ Sbjct: 51 --------NITEYAWDGMLGAVASGQADVAFSGISITDKRKKVIDFSEPYY 93 Score = 30.5 bits (67), Expect = 2.9, Method: Composition-based stats. Identities = 24/84 (28%), Positives = 37/84 (44%), Gaps = 6/84 (7%) Query: 696 RSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRK-PCDTMKVGGNLDSKGYG 754 S T E +A ++ A++ E + ++K P ++ V N+D G Sbjct: 142 YSLSKVKLYPTYNETMADLKNGNLDLAFIEEPVYFTFKNKKKMPIESRYVFKNVDQ--LG 199 Query: 755 IATPKGSSLRNAVNLAVLKLNEQG 778 IA KGS +R+ N L L EQG Sbjct: 200 IAFKKGSPVRDDFN---LWLKEQG 220 >5HPQ-A nrPDB Length = 255 Score = 69.1 bits (167), Expect = 7e-12, Method: Composition-based stats. Identities = 24/125 (19%), Positives = 49/125 (39%), Gaps = 20/125 (16%) Query: 417 VVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDA 476 V TT P+ + Y G+ VD+A +A+ G K + Sbjct: 27 VATTGDYKPFSYRTEEGG-------YAGFDVDMAQRLAESLGAKLVVVPTS--------- 70 Query: 477 DTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVF 536 W ++ + + DIA++ ++I L R+ FS P++ G + + ++++ Sbjct: 71 ----WPNLMRDFADDRFDIAMSGISINLERQRQAYFSIPYLRDGKTPITLCSEEARFQTL 126 Query: 537 SFLDP 541 +D Sbjct: 127 EQIDQ 131 >2PYY-A nrPDB Length = 228 Score = 67.5 bits (163), Expect = 2e-11, Method: Composition-based stats. Identities = 30/125 (24%), Positives = 53/125 (42%), Gaps = 20/125 (16%) Query: 416 VVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARD 475 ++V T + P+V L G+ +DL IA G + KL +Y + Sbjct: 5 LLVATRVIPPFV--------LSNKGELSGFSIDLWRSIATQIGIESKLI-----EYSSVP 51 Query: 476 ADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGV 535 ++ + K ++ IA ++IT RE+ DFS P + G+ IM++ + + Sbjct: 52 E-------LISAIKDNKVNLGIAAISITAEREQNFDFSLPIFASGLQIMVRNLESGTGDI 104 Query: 536 FSFLD 540 S D Sbjct: 105 RSIDD 109 Score = 67.5 bits (163), Expect = 2e-11, Method: Composition-based stats. Identities = 25/96 (26%), Positives = 40/96 (41%), Gaps = 1/96 (1%) Query: 694 YMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKP-CDTMKVGGNLDSKG 752 Y+R SV E + ++K A + ++ + + + VG L + Sbjct: 126 YLREHHISVLEVPKIEEAYKALQTKKADAVVFDAPVLLFYAANEGKGKVEIVGSILREES 185 Query: 753 YGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWW 788 YGI P S R +N A+L L E G L +KW+ Sbjct: 186 YGIILPNNSPYRKPINQALLNLKENGTYQSLYDKWF 221 >5EYF-A nrPDB Length = 245 Score = 65.2 bits (157), Expect = 1e-10, Method: Composition-based stats. Identities = 31/159 (19%), Positives = 56/159 (35%), Gaps = 17/159 (10%) Query: 443 EGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTI 502 +G+ VD+A I K + +GK + +K + L G D IA +TI Sbjct: 39 QGFDVDIAKAITKKI-------LGDNGKTEFVEVTSKT---RIPLLKNGNIDAIIATMTI 88 Query: 503 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF 562 T R++ +DFS + G ++++KK + S D A ++ S Sbjct: 89 TDERKKQVDFSDVYFDAGQALLVKKG----SQIKSVDDLNASTT---VLAVKGSTSAANI 141 Query: 563 LVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFS 601 E + + S + N++ Sbjct: 142 RQHAPDAKILELENYAEAFTALQSGQGDAMTTDNAILLG 180 Score = 49.8 bits (117), Expect = 5e-06, Method: Composition-based stats. Identities = 33/149 (22%), Positives = 60/149 (40%), Gaps = 23/149 (15%) Query: 649 RMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFV---R 705 + S I+S +DL+ T + + ++ R+ P + Sbjct: 112 KKGSQIKSVDDLNASTTVL--AVKGSTSAANIRQ---------------HAPDAKILELE 154 Query: 706 TTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSS-LR 764 AE ++ +G A ++ + I P + VGG ++ YGIA KG Sbjct: 155 NYAEAFTALQSGQGD-AMTTDNAILLGIADENP-EYELVGGTFTNEPYGIAINKGQENFL 212 Query: 765 NAVNLAVLKLNEQGLLDKLKNKWWYDKGE 793 AVN A+ +++ G DK+ KW+ ++ E Sbjct: 213 KAVNQALEEMHADGTYDKIYQKWFPNETE 241 >2Y7I-A nrPDB Length = 229 Score = 63.3 bits (152), Expect = 4e-10, Method: Composition-based stats. Identities = 29/181 (16%), Positives = 69/181 (38%), Gaps = 35/181 (19%) Query: 409 SGLENKTVVVTTIL-ESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVG 467 + + +T+ T +PY E ++ + + G+ +D+A + K + Sbjct: 1 ASVSARTLHFGTSATYAPY-------EFVDADNKIVGFDIDVANAVCKEMQAECSF---- 49 Query: 468 DGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKK 527 + ++ ++ L + K D IA + +T RE+ + FS+P+ G+S ++ Sbjct: 50 ---------TNQSFDSLIPSLRFKKFDAVIAGMDMTPKREQQVSFSQPYYE-GLSAVV-- 97 Query: 528 PQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFS-----PYEWHTEEFEDGRE 582 ++ G + ++ V G + +L + Y+ + F D + Sbjct: 98 --VTRKGAYHTF----ADLKGKKVGLENGTTHQRYLQDKQQAITPVAYDSYLNAFTDLKN 151 Query: 583 T 583 Sbjct: 152 N 152 >2IEE-A nrPDB Length = 271 Score = 62.5 bits (150), Expect = 8e-10, Method: Composition-based stats. Identities = 26/109 (23%), Positives = 45/109 (41%), Gaps = 13/109 (11%) Query: 431 KNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVY 490 H+ G+++ GY V++ E AK G K + +G +GM+ + Sbjct: 35 SYHDTDSGSDKLTGYEVEVVREAAKRLGLKVEFKEMGI-------------DGMLTAVNS 81 Query: 491 GKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFL 539 G+ D A + +T REE FS P+ + +++K S L Sbjct: 82 GQVDAAANDIDVTKDREEKFAFSTPYKYSYGTAIVRKDDLSGIKTLKDL 130 >5OTA-A nrPDB Length = 265 Score = 61.3 bits (147), Expect = 2e-09, Method: Composition-based stats. Identities = 23/114 (20%), Positives = 49/114 (42%), Gaps = 21/114 (18%) Query: 412 ENKTVVVTTI-LESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGK 470 + K++ + T +PY + + G+ +DL ++ K + K Sbjct: 3 DYKSITIATEGSYAPY-------NFKDAGGKLIGFDIDLGNDLCKRMNIECKFV------ 49 Query: 471 YGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIM 524 + W+G++ L G+ D +A + I RE+VI FS+P++ ++ + Sbjct: 50 -------EQAWDGIIPSLTAGRYDAIMAAMGIQPAREKVIAFSRPYLLTPMTFL 96 >5LOM-A nrPDB Length = 269 Score = 61.3 bits (147), Expect = 2e-09, Method: Composition-based stats. Identities = 27/171 (15%), Positives = 64/171 (37%), Gaps = 32/171 (18%) Query: 403 PSGNDTSG----LENKTVVVTTI-LESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHC 457 P G+ ++ T+ V T+ PY + + G+ ++L +A Sbjct: 16 PRGSHMDNPLGLIDPTTISVGTMGDAKPYAFT-------TADGNFTGFDIELFLNVAGRL 68 Query: 458 GFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFM 517 GFK + + + ++ ++ + G+ D+A A + T R+E +DFS ++ Sbjct: 69 GFKKEQVV----------FTGQEFSALMPSVANGRFDVAAAAIGTTAKRKETVDFSDGYL 118 Query: 518 SLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFS 568 + +S++ + + A + + G ++ F+ Sbjct: 119 AGFLSVLTSEAGIT----------DAAGLKGKRLGVVQGTLQEIYAEKNFA 159 Score = 33.2 bits (74), Expect = 0.47, Method: Composition-based stats. Identities = 32/153 (20%), Positives = 52/153 (33%), Gaps = 19/153 (12%) Query: 641 LAAFLTVERMVSPIESAEDLS-KQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAE 699 LA FL+V + I A L K+ + GTL ++ F + + F Sbjct: 118 LAGFLSVLTSEAGITDAAGLKGKRLGVVQGTLQEIYAEKNFAGTDLVKFPD--------- 168 Query: 700 PSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPK 759 V+ + +L +Y R P + V G K Sbjct: 169 -------NNSAVSALNNGTVDAHFLDFEAAKDY-SARYPALKIAVNIPSFDAPAGFVIRK 220 Query: 760 GSS-LRNAVNLAVLKLNEQGLLDKLKNKWWYDK 791 G+ LRNA++ + + + G KL KW+ Sbjct: 221 GNDALRNALDKGLKEAMQDGTWKKLHEKWFPGT 253 >3TQL-A nrPDB Length = 227 Score = 61.3 bits (147), Expect = 2e-09, Method: Composition-based stats. Identities = 27/143 (18%), Positives = 50/143 (34%), Gaps = 28/143 (19%) Query: 425 PYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGM 484 PYV M + + EG+ D+ + K + W+ + Sbjct: 14 PYVYMGPS-------GQVEGFGADIVKAVCKQMQ-------------AVCTISNQPWDSL 53 Query: 485 VGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAY 544 + L GK D + IT R++ +DF+ P+ + +S + K + P S Sbjct: 54 IPSLKLGKFDALFGGMNITTARQKEVDFTDPYYTNSVSFIADK---NTPLTLS-----KQ 105 Query: 545 EIWMCIVFAYIGVSVVLFLVSRF 567 + I+ G + +L F Sbjct: 106 GLKGKIIGVQGGTTFDSYLQDSF 128 >5OWF-A nrPDB Length = 259 Score = 59.4 bits (142), Expect = 6e-09, Method: Composition-based stats. Identities = 26/159 (16%), Positives = 52/159 (32%), Gaps = 29/159 (18%) Query: 414 KTVVVTT-ILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYG 472 +TV + T +P+ + + G+ +DL E+ K K Sbjct: 25 QTVRIGTDTTYAPF-------SSKDAKGEFIGFDIDLGNEMCKRMQVKCTWV-------- 69 Query: 473 ARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSK 532 ++ ++ L K D I+ L+IT R++ I FS + ++ K + Sbjct: 70 -----ASDFDALIPSLKAKKIDAIISSLSITDKRQQEIAFSDKLYAADSRLIAAKGSPIQ 124 Query: 533 PGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYE 571 P + S + V G + + + Sbjct: 125 PTLES--------LKGKHVGVKQGSTQEAYANDNWRTKG 155 >3VV5-A nrPDB Length = 260 Score = 59.4 bits (142), Expect = 6e-09, Method: Composition-based stats. Identities = 23/127 (18%), Positives = 47/127 (37%), Gaps = 23/127 (18%) Query: 434 EMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKA 493 + + G+ VDL IA+ G K + ++ ++ +L G+ Sbjct: 50 NYFDERNQLTGFEVDLGNAIAERLGLK-------------PRWIAQSFDTLLIQLNQGRF 96 Query: 494 DIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFA 553 D IA IT R +DF+ P G +++ + + A ++ +V Sbjct: 97 DFVIASHGITEERARAVDFTNPHYCTG-GVIVSRKGGPRT---------AKDLQGKVVGV 146 Query: 554 YIGVSVV 560 +G + + Sbjct: 147 QVGTTYM 153 >1HSL-A nrPDB Length = 238 Score = 59.4 bits (142), Expect = 7e-09, Method: Composition-based stats. Identities = 25/166 (15%), Positives = 54/166 (32%), Gaps = 29/166 (17%) Query: 414 KTVVVTTIL-ESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYG 472 + + + T +P+ E G+ +DLA E+ K + Sbjct: 4 QKIRIGTDPTYAPF-------ESKNAQGELVGFDIDLAKELCKRINTQCTFV-------- 48 Query: 473 ARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSK 532 + ++ L K D ++ L+IT R++ I F+ + +++ K Sbjct: 49 -----ENPLDALIPSLKAKKIDAIMSSLSITEKRQQEIAFTDKLYAADSRLVVAKN---- 99 Query: 533 PGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFE 578 S + P + V G + F ++P ++ Sbjct: 100 ----SDIQPTVASLKGKRVGVLQGTTQETFGNEHWAPKGIEIVSYQ 141 >3I6V-A nrPDB Length = 232 Score = 58.3 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 20/87 (22%), Positives = 37/87 (42%), Gaps = 13/87 (14%) Query: 431 KNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVY 490 + + +G+ +L E+ K G + W+ ++ LV Sbjct: 16 PPYNFINDAGEVDGFERELGDELCKRAGLTCEWV-------------KNDWDSIIPNLVS 62 Query: 491 GKADIAIAPLTITLVREEVIDFSKPFM 517 G D IA ++IT R+EVIDF++ ++ Sbjct: 63 GNYDTIIAGMSITDERDEVIDFTQNYI 89 Score = 39.4 bits (90), Expect = 0.008, Method: Composition-based stats. Identities = 29/160 (18%), Positives = 55/160 (34%), Gaps = 6/160 (3%) Query: 632 IIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKM 691 ++ +Y +A + I+ ++ T +Y G+ ++ A Sbjct: 60 LVSGNYDTIIAGMSITDERDEVIDFTQNYIPPTASSYVATSDGADLSGIVAAQTATIQAG 119 Query: 692 WTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSK 751 + S V T E +A VR + A + I + M VG ++ Sbjct: 120 Y-IAESGATLVEFATPEETIAAVRNGEAD-AVFADRDYLVPIVAESGGELMFVGDDVPLG 177 Query: 752 GYGIAT---PKGSSLRNAVNLAVLKLNEQGLLDKLKNKWW 788 G G+ LR + A+ + E G L+ + KW+ Sbjct: 178 G-GVGMGLRESDGELRGKFDAAITSMKEDGTLNTMIKKWF 216 >5ORE-A nrPDB Length = 263 Score = 56.7 bits (135), Expect = 5e-08, Method: Composition-based stats. Identities = 19/77 (24%), Positives = 37/77 (48%), Gaps = 13/77 (16%) Query: 440 ERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAP 499 + +G+ +DLA + + K ++ + W+G++ L K D +A Sbjct: 24 GKLDGFEIDLANALCEKMKAKCQIV-------------AQNWDGIMPSLTGKKYDAIMAA 70 Query: 500 LTITLVREEVIDFSKPF 516 +++T R+EVI FS P+ Sbjct: 71 MSVTPKRQEVIGFSIPY 87 Score = 31.7 bits (70), Expect = 1.3, Method: Composition-based stats. Identities = 18/80 (22%), Positives = 33/80 (41%), Gaps = 5/80 (6%) Query: 715 RKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKG-YGI---ATPK-GSSLRNAVNL 769 S A L +T+ ++ K+ G L S G +G+ K ++L+ + Sbjct: 172 LTSGRLDAVLANATVLAAAIEKPEMKGAKLVGPLFSGGEFGVVAVGLRKEDTALKADFDA 231 Query: 770 AVLKLNEQGLLDKLKNKWWY 789 A+ +E G + L KW+ Sbjct: 232 AIKAASEDGTIKTLSLKWFK 251 >5X2M-A nrPDB Length = 461 Score = 56.0 bits (133), Expect = 6e-08, Method: Composition-based stats. Identities = 51/333 (15%), Positives = 112/333 (33%), Gaps = 51/333 (15%) Query: 88 IFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRP----------DLKGALL 137 + G + +I T + S+ G+ + P D+ A++ Sbjct: 117 VVGPFTSTHALSIAPIFMTNLFPMV--SYGCSGSVFSKENLYPSFLRTVHSNKDVINAIV 174 Query: 138 SLIEYYQWDKFAYLY-DSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLF 196 +I + W A+LY D D G L+ + + + + N+N D Y +F Sbjct: 175 GIILNFNWRWVAFLYSDDDFGKDGLEQFKNKIEDSEICLAFYKAINVNTD-----YLQVF 229 Query: 197 QDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYI----------IANL--GFTD 244 + +E + + +++ + +V+ + + K +I + ++ Sbjct: 230 KQIEEQNIKVIVVFAPKVYAEAVVESAVQLNVTNK--VWIADDGWSLNKKLPSMNGIQNI 287 Query: 245 GDLLKIQFGGANVSGFQ-----IVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSAL 299 G +L + + GF + D ++ + + S Sbjct: 288 GTVLGVAQPVVTIPGFTDFIYSAISQTDGGDTEQKMFCNQKCNCSNLSVKSLLNADPSFS 347 Query: 300 --TYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLS 357 Y AV + A N R + C N V I LK+ L+ Sbjct: 348 FPVYAAVYAIAHALHNTL--------RCGSDRCPKNITV---HPHMILEELKKSNFTLLN 396 Query: 358 GNIKFDQNGKRINYTINIMELKTNG-PRKIGYW 389 ++FD+NG +++++ ++G ++G + Sbjct: 397 QTVQFDENGDPKFGSLSVVFWNSSGNAEEVGSY 429 >1IIT-A nrPDB Length = 232 Score = 56.0 bits (133), Expect = 6e-08, Method: Composition-based stats. Identities = 23/126 (18%), Positives = 46/126 (36%), Gaps = 19/126 (15%) Query: 416 VVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARD 475 + V + P+V + N + G +D+ +A+ + + G Sbjct: 6 LKVGVVGNPPFVFYGE-----GKNAAFTGISLDVWRAVAESQKWNSEYVRQNSISAG--- 57 Query: 476 ADTKIWNGMVGELVYGKADIAIAPLTITLVREEV--IDFSKPFMSLGISIMIKKPQKSKP 533 + + G+ DI I P+++T R + I F++P+ S GI ++I Sbjct: 58 ---------ITAVAEGELDILIGPISVTPERAAIEGITFTQPYFSSGIGLLIPGTATPLF 108 Query: 534 GVFSFL 539 L Sbjct: 109 RSVGDL 114 Score = 32.1 bits (71), Expect = 1.1, Method: Composition-based stats. Identities = 13/92 (14%), Positives = 32/92 (34%), Gaps = 1/92 (1%) Query: 698 AEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKP-CDTMKVGGNLDSKGYGIA 756 + V + + K A + + Y ++ P + + + YG Sbjct: 134 YQADVRETNNLTAAITLLQKKQVEAVMFDRPALIYYTRQNPNLNLEVTEIRVSLEPYGFV 193 Query: 757 TPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWW 788 + S L+ +N+ +L L ++ + +W Sbjct: 194 LKENSPLQKTINVEMLNLLYSRVIAEFTERWL 225 >4F11-A nrPDB Length = 433 Score = 54.8 bits (130), Expect = 2e-07, Method: Composition-based stats. Identities = 43/296 (14%), Positives = 102/296 (34%), Gaps = 30/296 (10%) Query: 113 TPSFPTDGTHPFVIQMRPD---LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAA 169 TP +P+ + P + A+L L+++YQW + L + S ++ L + Sbjct: 119 TPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDL-TGV 177 Query: 170 EKKWQVTAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKH 229 + + + +ND + L+ R ++ +++ + + Sbjct: 178 LYGEDIEISDTESFSNDPCTS-----VKKLKGNDVRIILGQFDQNMAAKVFCCAYEENMY 232 Query: 230 VKGYHYIIAN------LGFTDGDLLKIQFGGAN----VSGFQIVDYD---DSLVSKFIER 276 Y +II + + N + G+ VD++ + + Sbjct: 233 GSKYQWIIPGWYEPSWWEQVHTEANSSRCLRKNLLAAMEGYIGVDFEPLSSKQIKTISGK 292 Query: 277 WSTLEEKEYPGAHTTT-IKYTSALTYDAVQVMTEAFR-NLRKQRIEISRRGNAGDCLANP 334 E+EY + YD + V+ + + + + + Sbjct: 293 TPQQYEREYNNKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDH 352 Query: 335 AVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWS 390 + G I A+ + G++G + F +NG+R+ TI + + + K+G ++ Sbjct: 353 TL----GRIILNAMNETNFFGVTGQVVF-RNGERMG-TIKFTQFQDSREVKVGEYN 402 >1ISS-A nrPDB Length = 490 Score = 54.4 bits (129), Expect = 2e-07, Method: Composition-based stats. Identities = 54/355 (15%), Positives = 107/355 (30%), Gaps = 56/355 (15%) Query: 85 VYAIFGFYDKKSVNTITSFCGTLHVSFI-TPSFPTDGTHP----FVIQMRPD---LKGAL 136 + + G + + + I + D + + +++ P A+ Sbjct: 124 IAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAM 183 Query: 137 LSLIEYYQW-DKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSL 195 L +++ Y W A + + G S + A + AA++ + + N +K Sbjct: 184 LDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLR 243 Query: 196 FQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGA 255 L K R V+ CE V ++ + +G + +I + G+ D D + + Sbjct: 244 KLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGE--FSLIGSDGWADRDEVIEGYEVE 301 Query: 256 NVSGFQIVDY-----------------DDSLVSKFIERWSTLEEKEYPG----------A 288 G I ++ F E W + PG Sbjct: 302 ANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKV 361 Query: 289 HTTTIKYTSALTYDA-VQVMTEAFRNLR-----KQRIEISRRGNAGDCLANPAVPWGQGV 342 T D+ + + A + D + P G Sbjct: 362 CTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAM----KPI-DGR 416 Query: 343 EIERALKQVQVEGLSG-NIKFDQNGKRINYTINIMELKTNGPRK-----IGYWSE 391 ++ L + G+SG + FD+ G +IM L+ + +G W E Sbjct: 417 KLLDFLIKSSFVGVSGEEVWFDEKGDAPG-RYDIMNLQYTEANRYDYVHVGTWHE 470 >3DEL-B nrPDB Length = 242 Score = 53.6 bits (127), Expect = 3e-07, Method: Composition-based stats. Identities = 22/122 (18%), Positives = 43/122 (35%), Gaps = 22/122 (18%) Query: 414 KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGA 473 + +V T P E ++ G+ +DLA EI+ G + Sbjct: 11 EKFIVGTNATYPPF------EFVDKRGEVVGFDIDLAREISNKLGKTLDVR--------- 55 Query: 474 RDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGIS--IMIKKPQKS 531 ++ ++ L + D I ++IT R + I P+ I +++ K + Sbjct: 56 ----EFSFDALILNLKQHRIDAVITGMSITPSRLKEI-LMIPYYGEEIKHLVLVFKGENK 110 Query: 532 KP 533 P Sbjct: 111 HP 112 >4Q0C-A nrPDB Length = 584 Score = 45.9 bits (107), Expect = 8e-05, Method: Composition-based stats. Identities = 20/114 (17%), Positives = 47/114 (41%), Gaps = 20/114 (17%) Query: 417 VVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDA 476 V L +P+ + + +E++ G + + G +++ V + Sbjct: 344 VAVLNLFAPFTLFRT-------DEQFGGISAAVLQLLQLRTGLDFEIIGVDTVEE----- 391 Query: 477 DTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQK 530 ++ +L G+AD+A L + RE + FS+P++ G+ I+ ++ Sbjct: 392 -------LIAKLRSGEADMA-GALFVNSARESFLSFSRPYVRNGMVIVTRQDPD 437 >1YK0-A nrPDB Length = 480 Score = 40.9 bits (94), Expect = 0.003, Method: Composition-based stats. Identities = 49/356 (13%), Positives = 107/356 (30%), Gaps = 48/356 (13%) Query: 43 AFRVGMVQF---STSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNT 99 F+V + + F L + A + C + V + +D ++ Sbjct: 98 RFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSA 157 Query: 100 ITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDR--- 156 G L F V + +L+L ++ W + A +Y D+ Sbjct: 158 -----GALAAGF-QHKDSEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALVYSDDKLER 211 Query: 157 -GLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDK 215 TL+ V + E+ + + + +++ R++ ER VI+ D Sbjct: 212 NCYFTLEGVHEVFQEEGLHTSIYSFDETKDLDLEDIVRNIQ-----ASERVVIMCASSDT 266 Query: 216 VNDIVDQVITIGKHVKGYHYIIANL-----------GFTDGDLLKIQFGGANVSGFQIVD 264 + I+ G Y + L D + + +++ ++ Sbjct: 267 IRSIMLVAHRHGMTSGDYAFFNIELFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLLR 326 Query: 265 YDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRR 324 KF + EK+ + +DA+ + A + + + Sbjct: 327 TVKPEFEKFSMEVKSSVEKQGLNMEDYVNMFVEGF-HDAILLYVLALHEVLRAG---YSK 382 Query: 325 GNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKT 380 + G + W EG++G + D NG R +++ + Sbjct: 383 KDGGKIIQQT---W-----------NRTFEGIAGQVSIDANGDR-YGDFSVIAMTD 423 >2Q88-A nrPDB Length = 257 Score = 40.2 bits (92), Expect = 0.005, Method: Composition-based stats. Identities = 19/94 (20%), Positives = 33/94 (35%), Gaps = 12/94 (12%) Query: 436 LEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADI 495 + + + G D+A EI K G A + M+ L G+ D Sbjct: 28 VGADGKVSGAAPDVAREIFKRLGV------------ADVVASISEYGAMIPGLQAGRHDA 75 Query: 496 AIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ 529 A L + R + +S+P + + +KK Sbjct: 76 ITAGLFMKPERCAAVAYSQPILCDAEAFALKKGN 109 >3A3K-A nrPDB Length = 435 Score = 37.5 bits (85), Expect = 0.026, Method: Composition-based stats. Identities = 35/253 (13%), Positives = 89/253 (35%), Gaps = 40/253 (15%) Query: 178 INVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHY-- 235 I V + + D + +K R + + D +++ + G + Y + Sbjct: 181 ITVNHQEFVEGDPDHYPKLLRAVRRKGRVIYICSSPDAFRNLMLLALNAGLTGEDYVFFH 240 Query: 236 --IIANLGFTDGDLLK----------IQFGGANVSGFQIVDY---DDSLVSKFIERWSTL 280 + + L+ + +I+ Y D+ +F+++ L Sbjct: 241 LDVFGQSLKSAQGLVPQKPWERGDGQDRSARQAFQAAKIITYKEPDNPEYLEFLKQLKLL 300 Query: 281 EEKEYPGAHTTTIKYT-SALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWG 339 +K++ +K A +D + + +A Q ++ Sbjct: 301 ADKKFNFTVEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTD---------------- 344 Query: 340 QGVEIERALKQVQVEGLSGNIKFDQNGKR-INYTINIMELKTNGPRKIGYWSEVDKMVVT 398 G I + + +G++G +K D+NG R ++++ M+ +T R + ++ + ++ Sbjct: 345 -GENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNYNGTSQELMA 403 Query: 399 LTE----LPSGND 407 ++E P G Sbjct: 404 VSEHKLYWPLGYP 416 >1RHC-A nrPDB Length = 330 Score = 37.5 bits (85), Expect = 0.029, Method: Composition-based stats. Identities = 22/140 (15%), Positives = 48/140 (34%), Gaps = 14/140 (10%) Query: 466 VGDGKYGARDADTKIWNGMVGELVYGKADI---AIAPLTITLVREEVIDFSKPFMSLGIS 522 VG G+ T W V + D+ A+ + + ++ + F + +L + Sbjct: 104 VGAGEAMNEVPVTGEWPS-----VPVRQDMTVEAVKVMRMLWESDKPVTFKGDYFTLDKA 158 Query: 523 IMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRE 582 + KP P FS + P ++ + V+ + +FE+G Sbjct: 159 FLYTKPDDEVPLYFSGMGPKGAKLAGMYGDHLMTVAAAPSTLKNV-----TIPKFEEGAR 213 Query: 583 TQSSESTNEFGIFNSLWFSL 602 + + +W+S+ Sbjct: 214 EAGKDPSKMEHAM-LIWYSV 232 >2O1M-A nrPDB Length = 258 Score = 35.5 bits (80), Expect = 0.11, Method: Composition-based stats. Identities = 24/129 (18%), Positives = 46/129 (35%), Gaps = 25/129 (19%) Query: 414 KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHC---GFKYKLTIVGDGK 470 +T+ V T + P N ++ GY V+L E+ K F +K Sbjct: 16 QTITVGTGTQFP------NICFIDEKGDLTGYDVELIKELDKRLPHYKFTFK-------- 61 Query: 471 YGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSK-PFMSLGISIMIKKPQ 529 T ++ ++ L K DI + + RE+ F+K + + I + + Sbjct: 62 -------TMEFSNLLVSLGQHKVDIVAHQMEKSKEREKKFLFNKVAYNHFPLKITVLQNN 114 Query: 530 KSKPGVFSF 538 + G+ Sbjct: 115 DTIRGIEDL 123 >3PNZ-A nrPDB Length = 330 Score = 34.0 bits (76), Expect = 0.26, Method: Composition-based stats. Identities = 19/138 (13%), Positives = 46/138 (33%), Gaps = 14/138 (10%) Query: 127 QMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINND 186 +++P+LK + YY+W + ++ L + + E + T G + Sbjct: 104 KIKPELKPIIGDFETYYEW-----IENTTTD--KLTEFVVNEVENGLEGTPYKAGQVKFG 156 Query: 187 KKDEMYRSLFQDL-----ELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLG 241 M L + E + + + ++Q+ + + Y+ ++G Sbjct: 157 TGYNMITPLEEKTIRAVARAHHETKAPIHSHTEAGTMALEQIEILKQENIPLEYL--SIG 214 Query: 242 FTDGDLLKIQFGGANVSG 259 D +L +G Sbjct: 215 HMDRNLDPYYHKQVAKTG 232 >3CPX-A nrPDB Length = 321 Score = 30.5 bits (67), Expect = 3.6, Method: Composition-based stats. Identities = 13/74 (17%), Positives = 29/74 (39%) Query: 654 IESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVAR 713 + +L++QT+I + G+ R +++ + W ++ + E Sbjct: 247 VNRIIELARQTDIPFQLEVEGAGASDGRELQLSPYPWDWCFIGAPEKDAHTPNECVHKKD 306 Query: 714 VRKSKGKYAYLLES 727 + G Y YL+E Sbjct: 307 IESMVGLYKYLMEK 320 >3DBM-A nrPDB Length = 473 Score = 29.8 bits (65), Expect = 5.4, Method: Composition-based stats. Identities = 17/99 (17%), Positives = 33/99 (33%), Gaps = 2/99 (2%) Query: 535 VFSFLDPLAYE-IWMCIVFAYIGVSVVLFLVSRFSP-YEWHTEEFEDGRETQSSESTNEF 592 V S+LDP + + ++ + ++ +F Y E E + N+ Sbjct: 108 VLSYLDPSEPRHAQLKNLLFFMLKNSSNRVIPQFETTYTELFEGLEAELAKNGKAAFNDV 167 Query: 593 GIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTL 631 G + F A+ + + S + W F L Sbjct: 168 GEQAAFRFLGRAYFNSNPEETKLGTSAPTLISSWVLFNL 206 >3QS1-A nrPDB Length = 336 Score = 29.8 bits (65), Expect = 5.7, Method: Composition-based stats. Identities = 16/66 (24%), Positives = 24/66 (36%), Gaps = 5/66 (7%) Query: 456 HCGFKYKLTIVGDGKYGARDADTKIWNGMVG----ELVYGKADIAIAPLTI-TLVREEVI 510 + F YK V D ++G+VG +L G D + L + + V Sbjct: 102 NLSFPYKFIEVTDTNGFEPAYTLGQFDGIVGLGWKDLSIGSVDPVVVELKNQNKIEQAVF 161 Query: 511 DFSKPF 516 F PF Sbjct: 162 TFYLPF 167 >3ULE-B nrPDB Length = 394 Score = 29.8 bits (65), Expect = 6.2, Method: Composition-based stats. Identities = 21/132 (15%), Positives = 44/132 (33%), Gaps = 8/132 (6%) Query: 441 RYEGYCVDLAAEIAKHCGFKYKLTIVGDG---KYGARDADTKIWNGMVGELVYGKADIAI 497 Y GY ++ ++A + + DG K G + + + + + Sbjct: 221 CYVGYNIEQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPE--ALFQPHLINVEGVGV 278 Query: 498 APLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGV 557 A L ++ ID F I++ PG+ S L+ ++++ V Sbjct: 279 AELLFNTIQAADIDTRSEFYKH---IVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVE 335 Query: 558 SVVLFLVSRFSP 569 + F + P Sbjct: 336 KLSKFKIRIEDP 347 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.124 0.315 Lambda K H 0.267 0.0380 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 29,134,748 Number of Sequences: 36641 Number of extensions: 1080812 Number of successful extensions: 3636 Number of sequences better than 10.0: 83 Number of HSP's better than 10.0 without gapping: 127 Number of HSP's successfully gapped in prelim test: 30 Number of HSP's that attempted gapping in prelim test: 3050 Number of HSP's gapped (non-prelim): 241 length of query: 883 length of database: 10,336,785 effective HSP length: 106 effective length of query: 777 effective length of database: 6,452,839 effective search space: 5013855903 effective search space used: 5013855903 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 63 (29.0 bits)