BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P41318 (303 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 6EMK-B nrPDB 631 0.0 5FVM-C nrPDB 557 e-159 5WBU-D nrPDB 303 5e-83 5NNZ-B nrPDB 103 7e-23 1VYH-C nrPDB 99 2e-21 5MZH-A nrPDB 92 3e-19 6QX9-5O nrPDB 88 6e-18 2H9P-A nrPDB 87 6e-18 5M25-A nrPDB 87 9e-18 5FL8-q nrPDB 79 2e-15 5I2T-A nrPDB 77 8e-15 5WLC-LO nrPDB 76 1e-14 5WYJ-BC nrPDB 76 1e-14 4V8M-A7 nrPDB 76 2e-14 6G51-g nrPDB 75 3e-14 3JB9-L nrPDB 74 5e-14 6F3T-A nrPDB 74 6e-14 6HHQ-h nrPDB 73 2e-13 6MZM-G nrPDB 73 2e-13 5K1B-B nrPDB 72 3e-13 6Q8F-A nrPDB 72 3e-13 6HQA-B nrPDB 70 1e-12 5XYI-g nrPDB 69 2e-12 3ODT-A nrPDB 69 2e-12 4LG8-A nrPDB 69 2e-12 6ID0-T nrPDB 69 2e-12 5Z56-q nrPDB 68 6e-12 5OPT-p nrPDB 67 6e-12 3DM0-A nrPDB 67 7e-12 4V7E-Bg nrPDB 66 2e-11 6QX9-4B nrPDB 65 2e-11 5UZ7-B nrPDB 65 4e-11 3JB9-g nrPDB 65 5e-11 6GMH-W nrPDB 64 8e-11 5WYK-BB nrPDB 62 2e-10 5Y88-O nrPDB 62 2e-10 3JAP-g nrPDB 62 3e-10 5OQL-d nrPDB 62 3e-10 4U1E-I nrPDB 62 4e-10 5NZU-C nrPDB 61 5e-10 4V6W-Ag nrPDB 60 9e-10 6BX3-A nrPDB 60 1e-09 3FM0-A nrPDB 59 3e-09 6J6H-n nrPDB 57 1e-08 6QDV-o nrPDB 56 2e-08 5YZG-W nrPDB 55 3e-08 5OQL-L nrPDB 55 3e-08 5L9T-R nrPDB 55 4e-08 6N9G-C nrPDB 55 6e-08 5OV3-A nrPDB 54 6e-08 6EOJ-D nrPDB 53 1e-07 5A9Q-0 nrPDB 53 1e-07 6BX3-B nrPDB 53 2e-07 4BTS-AR nrPDB 53 2e-07 4XYI-A nrPDB 52 2e-07 4AEZ-A nrPDB 52 2e-07 4BZK-B nrPDB 52 3e-07 2HES-X nrPDB 52 3e-07 3JRP-A nrPDB 52 3e-07 5GAN-H nrPDB 52 3e-07 5LTD-A nrPDB 52 4e-07 3JRO-A nrPDB 51 6e-07 5WJC-A nrPDB 51 8e-07 3ACP-A nrPDB 50 8e-07 6ELZ-p nrPDB 50 1e-06 5OQL-X nrPDB 50 1e-06 4G56-B nrPDB 49 2e-06 5CXC-A nrPDB 49 3e-06 5OQL-J nrPDB 49 4e-06 4YCZ-A nrPDB 49 4e-06 4J0W-A nrPDB 48 6e-06 4XFV-A nrPDB 48 6e-06 4E5Z-B nrPDB 47 1e-05 2YNP-A nrPDB 47 1e-05 3MKQ-A nrPDB 47 1e-05 4N14-A nrPDB 47 1e-05 4A11-B nrPDB 46 2e-05 5WLC-LJ nrPDB 46 2e-05 5LCW-Q nrPDB 45 3e-05 6CHG-A nrPDB 45 4e-05 4GGA-A nrPDB 45 4e-05 5MWJ-A nrPDB 45 5e-05 5WLC-LU nrPDB 44 7e-05 5FA5-B nrPDB 44 8e-05 6E29-D nrPDB 44 8e-05 6EM1-m nrPDB 44 1e-04 6CB1-s nrPDB 44 1e-04 6C0F-s nrPDB 44 1e-04 5G04-R nrPDB 44 1e-04 5WYJ-BE nrPDB 44 1e-04 5A9Q-2 nrPDB 44 1e-04 3EI3-B nrPDB 42 3e-04 5N4A-A nrPDB 42 3e-04 4OWR-A nrPDB 42 4e-04 3W15-A nrPDB 41 6e-04 4L9O-A nrPDB 41 7e-04 3C9C-A nrPDB 40 0.001 6F1U-h nrPDB 40 0.001 5Y1U-A nrPDB 40 0.001 1NR0-A nrPDB 40 0.001 3JB9-S nrPDB 40 0.001 4BH6-A nrPDB 40 0.002 5TF2-A nrPDB 39 0.002 5BJS-A nrPDB 39 0.002 5K19-A nrPDB 39 0.003 3CFV-B nrPDB 39 0.003 5A31-R nrPDB 39 0.003 5YZG-2 nrPDB 39 0.003 3BG0-A nrPDB 39 0.004 5K0Y-T nrPDB 38 0.005 1PI6-A nrPDB 38 0.006 5WLC-LW nrPDB 37 0.010 3JZG-A nrPDB 36 0.024 6CHG-D nrPDB 35 0.037 5M89-A nrPDB 35 0.057 5WLC-LN nrPDB 34 0.070 5CXB-B nrPDB 34 0.077 2AQ5-A nrPDB 34 0.082 3I2N-A nrPDB 34 0.083 5A9Q-7 nrPDB 33 0.16 5AMS-A nrPDB 33 0.20 5WLC-LV nrPDB 31 0.53 5IT7-II nrPDB 31 0.68 4J0X-A nrPDB 31 0.75 4FHN-A nrPDB 31 0.75 1CKM-A nrPDB 30 0.97 2I3T-A nrPDB 30 1.0 5MC6-j nrPDB 30 1.6 3MWP-A nrPDB 30 1.7 5SUM-A nrPDB 30 1.7 4PSX-B nrPDB 30 1.7 5WLC-SG nrPDB 30 1.8 6IYY-A nrPDB 30 1.8 4AV8-A nrPDB 29 2.1 5WLC-LS nrPDB 29 2.1 6N8P-A nrPDB 29 3.2 3F3P-A nrPDB 28 4.4 1A3W-A nrPDB 28 6.6 >6EMK-B nrPDB Length = 303 Score = 631 bits (1627), Expect = 0.0, Method: Compositional matrix adjust. Identities = 303/303 (100%), Positives = 303/303 (100%) Query: 1 MSVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDI 60 MSVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDI Sbjct: 1 MSVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDI 60 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVN 120 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVN Sbjct: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVN 120 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK Sbjct: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 Query: 181 GNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDF 240 GNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDF Sbjct: 181 GNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDF 240 Query: 241 KLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVAL 300 KLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVAL Sbjct: 241 KLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVAL 300 Query: 301 NDV 303 NDV Sbjct: 301 NDV 303 >5FVM-C nrPDB Length = 303 Score = 557 bits (1436), Expect = e-159, Method: Compositional matrix adjust. Identities = 259/303 (85%), Positives = 287/303 (94%) Query: 1 MSVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDI 60 MSVIL SAGYDHTIRFWEALTGVCSRTIQH+DSQVNRLEIT+DKK LA AGH +VRLYDI Sbjct: 1 MSVILASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGHLHVRLYDI 60 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVN 120 R+ NPNPV+SFEGH+GNVTS++FQQ+NRWMV+SSEDGTIKVWDVRSPS+ RNYKHNAPVN Sbjct: 61 RSNNPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYKHNAPVN 120 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 EV IHPNQGELISCD+DGNIRIWDLGENQCT+QLTPED+T LQSLS+ASDGSML A N K Sbjct: 121 EVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNK 180 Query: 181 GNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDF 240 GNCYVW MP+HTDAS L+PVTKF++H+ YITR+LLS+DVK+LATCSADHTARVW+I+D++ Sbjct: 181 GNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNIEDNY 240 Query: 241 KLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVAL 300 +LETTLDGHQRWVWDCAFSADSAYLVTA SDHYVRLWDLST EIVRQYGGHHKGAVCVAL Sbjct: 241 QLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLSTSEIVRQYGGHHKGAVCVAL 300 Query: 301 NDV 303 NDV Sbjct: 301 NDV 303 >5WBU-D nrPDB Length = 328 Score = 303 bits (777), Expect = 5e-83, Method: Compositional matrix adjust. Identities = 148/312 (47%), Positives = 202/312 (64%), Gaps = 14/312 (4%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRT 62 VIL +AGYDHT+RFW+A +G+C+RT+QH DSQVN LE+T D+ ++A AG+Q++R+YD+ + Sbjct: 15 VILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNS 74 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSI--PRNYKHNAPVN 120 NPNP+ S++G N+ SV F +D RWM T ED T ++WD+RS ++ R ++ NAP+N Sbjct: 75 NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPIN 134 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 V +HPNQ ELI D+ G I IWDL + QL PE + S+ S + D S +AA N+ Sbjct: 135 CVCLHPNQAELIVGDQSGAIHIWDLKTDH-NEQLIPEPEVSITSAHIDPDASYMAAVNST 193 Query: 181 GNCYVWEMPNHT--DASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDD 238 GNCYVW + + + L P TK AH+ Y + S D LATCSAD T ++W Sbjct: 194 GNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRT-S 252 Query: 239 DFKLETTL--------DGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGG 290 +F L T L + + W+W CAFS DS Y+VTASSD+ RLW + T EI R+YGG Sbjct: 253 NFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGG 312 Query: 291 HHKGAVCVALND 302 H K VC+A ND Sbjct: 313 HQKAVVCLAFND 324 >5NNZ-B nrPDB Length = 415 Score = 103 bits (258), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 71/275 (25%), Positives = 122/275 (44%), Gaps = 12/275 (4%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQN-VRLYDIRTT 63 + + +D T + W TG C T + +++ L L+AT +L+DI+ Sbjct: 150 IATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ-- 207 Query: 64 NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSP-SIPRNYKHNAPVNEV 122 N V + GH + S+SF ++T S D T+ VWD + + H A ++ Sbjct: 208 NGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSA 267 Query: 123 VIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGN 182 + + +++ D ++WD +C LT DD L S G ++A A+ G Sbjct: 268 SFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDS-CFDYTGKLIATASADGT 326 Query: 183 CYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKL 242 ++ A+ K + K H I++I + HL T S+D TAR+W L Sbjct: 327 ARIFS------AATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCL 380 Query: 243 ETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 + L+GH ++ CAF+ ++T S D+ R+W Sbjct: 381 QV-LEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414 Score = 83.6 bits (205), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 70/300 (23%), Positives = 127/300 (42%), Gaps = 13/300 (4%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITN--DKKLLATAGHQNVRLYDIRT 62 ++ YD T + W+ +G T++ + V + N K+ + + +L+ + T Sbjct: 107 FITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVET 166 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNE 121 +F GH + +SF + + T S D T K+WD+++ + H+A + Sbjct: 167 --GKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIIS 224 Query: 122 VVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKG 181 + + + +I+ D + +WD + + L + S S D S++ + Sbjct: 225 LSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHC-AEISSASFNWDCSLILTGSMDK 283 Query: 182 NCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFK 241 C +W DA++ K V H I K +AT SAD TAR++S K Sbjct: 284 TCKLW------DATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATR-K 336 Query: 242 LETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 L+GH+ + +F+ +L+T SSD R+WD T + ++ GH A N Sbjct: 337 CIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFN 396 Score = 57.0 bits (136), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 34/142 (23%), Positives = 63/142 (44%), Gaps = 4/142 (2%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQN-VRLYDIRT 62 ++++ D T + W+A G C T+ D ++ KL+ATA R++ T Sbjct: 275 LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAAT 334 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNE 121 +A EGH G ++ +SF ++T S D T ++WD ++ + + H + Sbjct: 335 --RKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFS 392 Query: 122 VVIHPNQGELISCDRDGNIRIW 143 + +I+ +D RIW Sbjct: 393 CAFNYKGNIVITGSKDNTCRIW 414 Score = 43.9 bits (102), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 46/100 (46%), Gaps = 2/100 (2%) Query: 203 FRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADS 262 +AH +T + L+ T S D T ++W +L TL+GH+ V+ AF+ Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELN-TLEGHRNVVYAIAFNNPY 146 Query: 263 A-YLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 + T S D +LW + T + + GH VC++ N Sbjct: 147 GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFN 186 Score = 30.4 bits (67), Expect = 0.91, Method: Compositional matrix adjust. Identities = 16/63 (25%), Positives = 27/63 (42%) Query: 240 FKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVA 299 F L L H + + A + + +T S D +LWD ++ E + GH +A Sbjct: 82 FYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIA 141 Query: 300 LND 302 N+ Sbjct: 142 FNN 144 >1VYH-C nrPDB Length = 410 Score = 99.0 bits (245), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 80/298 (26%), Positives = 136/298 (45%), Gaps = 34/298 (11%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLAT-AGHQNVRLYDIRT 62 ++VSA D TI+ W+ TG RT++ V + + KLLA+ + ++L+D + Sbjct: 122 VMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ- 180 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNE 121 + + GH NV+SVS + +V++S D TIK+W+V++ + + H V Sbjct: 181 -GFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVR- 238 Query: 122 VVIHPNQ-GELI-SCDRDGNIRIWDLGENQCTHQL------------TPEDDTSLQSLSM 167 ++ PNQ G LI SC D +R+W + +C +L PE S S + Sbjct: 239 -MVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHRHVVECISWAPESSYSSISEAT 297 Query: 168 ASD-------GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVK 220 S+ G L + + +W D S + H ++ +L S K Sbjct: 298 GSETKKSGKPGPFLLSGSRDKTIKMW------DVSTGMCLMTLVGHDNWVRGVLFHSGGK 351 Query: 221 HLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWD 278 + +C+ D T RVW + + TL+ H+ +V F + Y+VT S D V++W+ Sbjct: 352 FILSCADDKTLRVWDYKNK-RCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 70/273 (25%), Positives = 117/273 (42%), Gaps = 31/273 (11%) Query: 42 NDKKLLATAGHQNVRLYDIRTTNPNPVASF--EGHRGNVTSVSFQQDNRWMVTSSEDGTI 99 N+ K T+G + D + P P + GHR VT V F MV++SED TI Sbjct: 73 NEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATI 132 Query: 100 KVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPED 158 KVWD + R K H V ++ + L SC D I++WD +C + D Sbjct: 133 KVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHD 192 Query: 159 DTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSD 218 ++ S+S+ +G + +A+ +WE+ V F H ++ + + D Sbjct: 193 H-NVSSVSIMPNGDHIVSASRDKTIKMWEVQTGY------CVKTFTGHREWVRMVRPNQD 245 Query: 219 VKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAY-------------- 264 +A+CS D T RVW + + + L H+ V +++ +S+Y Sbjct: 246 GTLIASCSNDQTVRVWVVATK-ECKAELREHRHVVECISWAPESSYSSISEATGSETKKS 304 Query: 265 ------LVTASSDHYVRLWDLSTREIVRQYGGH 291 L++ S D +++WD+ST + GH Sbjct: 305 GKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGH 337 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 46/200 (23%), Positives = 85/200 (42%), Gaps = 8/200 (4%) Query: 100 KVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDD 159 K W R P H +PV V+ HP ++S D I++WD L D Sbjct: 92 KEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTD 151 Query: 160 TSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDV 219 S+Q +S G +LA+ + +W D + + H ++ + + + Sbjct: 152 -SVQDISFDHSGKLLASCSADMTIKLW------DFQGFECIRTMHGHDHNVSSVSIMPNG 204 Query: 220 KHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDL 279 H+ + S D T ++W + + ++T GH+ WV + D + + S+D VR+W + Sbjct: 205 DHIVSASRDKTIKMWEVQTGYCVKT-FTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVV 263 Query: 280 STREIVRQYGGHHKGAVCVA 299 +T+E + H C++ Sbjct: 264 ATKECKAELREHRHVVECIS 283 Score = 53.9 bits (128), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 32/103 (31%), Positives = 55/103 (53%), Gaps = 3/103 (2%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEI-TNDKKLLATAGHQNVRLYDIRT 62 L+S D TI+ W+ TG+C T+ D+ V + + K +L+ A + +R++D + Sbjct: 310 FLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYK- 368 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVR 105 N + + H VTS+ F + ++VT S D T+KVW+ R Sbjct: 369 -NKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410 >5MZH-A nrPDB Length = 452 Score = 92.0 bits (227), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 70/279 (25%), Positives = 129/279 (46%), Gaps = 20/279 (7%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQN-VRLYDIRTT 63 +V+ +D T + W+A TG T++ +++ L ++AT N +L+D+ T Sbjct: 152 IVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETG 211 Query: 64 NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEV 122 A+ GHR + S+ F +VT S D ++WDVR+ H V+ Sbjct: 212 QER--ATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQCVHVLSGHRGEVSST 269 Query: 123 VIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASD--GSMLAAANTK 180 + ++S D R+WD+ +C L+ + + + L +A D G+ + +A+ Sbjct: 270 QFNYAGTLVVSGSIDCTSRLWDVRSGRC---LSVKQGHTDEVLDVAFDAAGTKMVSASAD 326 Query: 181 GNCYVWEMPNHTDASHLKPVTK--FRAHSTYITRILLSSDVKHLATCSADHTARVWSIDD 238 G+ ++ HT L V + H I+++ + L T S+D T R+W D Sbjct: 327 GSARLY----HT----LTGVCQHTLVGHEGEISKVAFNPQGTRLITASSDKTCRLWDCDT 378 Query: 239 DFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 L+ L+GH ++ CAF+ + +++T S D+ R+W Sbjct: 379 GECLQV-LEGHTDEIFSCAFNYEGDFIITGSKDNTCRIW 416 Score = 80.9 bits (198), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 67/300 (22%), Positives = 126/300 (42%), Gaps = 13/300 (4%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITN--DKKLLATAGHQNVRLYDIRT 62 ++ YD T + W TG T++ + V + N K++ + + +L+D T Sbjct: 109 FITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYT 168 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNE 121 + +GH+ + +SF + + T S D T K+WDV + H A + Sbjct: 169 --GQLYYTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETGQERATLAGHRAEIVS 226 Query: 122 VVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKG 181 + + +++ D + R+WD+ QC H L+ + S G+++ + + Sbjct: 227 LGFNTGGDLIVTGSFDHDSRLWDVRTGQCVHVLSGHRG-EVSSTQFNYAGTLVVSGSIDC 285 Query: 182 NCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFK 241 +W D + ++ + H+ + + + + + SAD +AR++ Sbjct: 286 TSRLW------DVRSGRCLSVKQGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTGV- 338 Query: 242 LETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 + TL GH+ + AF+ L+TASSD RLWD T E ++ GH A N Sbjct: 339 CQHTLVGHEGEISKVAFNPQGTRLITASSDKTCRLWDCDTGECLQVLEGHTDEIFSCAFN 398 Score = 73.9 bits (180), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 58/235 (24%), Positives = 100/235 (42%), Gaps = 11/235 (4%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGH-QNVRLYDI 60 S I+ + D+T + W+ TG T+ +++ L L+ T + RL+D+ Sbjct: 191 STIIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDV 250 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSP-SIPRNYKHNAPV 119 RT V S GHRG V+S F +V+ S D T ++WDVRS + H V Sbjct: 251 RTGQCVHVLS--GHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEV 308 Query: 120 NEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANT 179 +V +++S DG+ R++ C H L + + ++ G+ L A++ Sbjct: 309 LDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEG-EISKVAFNPQGTRLITASS 367 Query: 180 KGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVW 234 C +W D + + H+ I + + + T S D+T R+W Sbjct: 368 DKTCRLW------DCDTGECLQVLEGHTDEIFSCAFNYEGDFIITGSKDNTCRIW 416 Score = 64.3 bits (155), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 43/187 (22%), Positives = 80/187 (42%), Gaps = 7/187 (3%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNV--RLYDIR 61 ++V+ +DH R W+ TG C + +V+ + N L +G + RL+D+R Sbjct: 235 LIVTGSFDHDSRLWDVRTGQCVHVLSGHRGEVSSTQF-NYAGTLVVSGSIDCTSRLWDVR 293 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVN 120 + V +GH V V+F MV++S DG+ +++ + H ++ Sbjct: 294 SGRCLSVK--QGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEGEIS 351 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 +V +P LI+ D R+WD +C L D + S + +G + + Sbjct: 352 KVAFNPQGTRLITASSDKTCRLWDCDTGECLQVLEGHTD-EIFSCAFNYEGDFIITGSKD 410 Query: 181 GNCYVWE 187 C +W+ Sbjct: 411 NTCRIWK 417 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 28/105 (26%), Positives = 53/105 (50%), Gaps = 3/105 (2%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEIT-NDKKLLATAGHQNVRLYDIRTT 63 +VSA D + R + LTGVC T+ + +++++ +L+ + + RL+D T Sbjct: 320 MVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQGTRLITASSDKTCRLWDCDTG 379 Query: 64 NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS 108 V EGH + S +F + +++T S+D T ++W + S Sbjct: 380 ECLQV--LEGHTDEIFSCAFNYEGDFIITGSKDNTCRIWKALTAS 422 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 32/102 (31%), Positives = 46/102 (45%), Gaps = 6/102 (5%) Query: 203 FRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLET--TLDGHQRWVWDCAFSA 260 RAH +T + T S D T +VW + F E TL+GH+ V+ AF+ Sbjct: 90 LRAHILPLTNCAFNKSGDRFITGSYDRTCKVW---NTFTGEEVFTLEGHKNVVYAIAFNN 146 Query: 261 DSA-YLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 +VT S D +LWD T ++ GH VC++ N Sbjct: 147 PYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFN 188 Score = 32.7 bits (73), Expect = 0.18, Method: Compositional matrix adjust. Identities = 18/63 (28%), Positives = 27/63 (42%) Query: 240 FKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVA 299 F L L H + +CAF+ +T S D ++W+ T E V GH +A Sbjct: 84 FTLFKVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIA 143 Query: 300 LND 302 N+ Sbjct: 144 FNN 146 >6QX9-5O nrPDB Length = 357 Score = 87.8 bits (216), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 73/281 (25%), Positives = 129/281 (45%), Gaps = 11/281 (3%) Query: 5 LVSAGYDHTIRFWEALTGVCSR--TIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIR 61 L SAG+D I W + G C T++ V L D +L +A + V ++D Sbjct: 81 LASAGFDRLILLWN-VYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSE 139 Query: 62 TTNPNPVASFEGHRGNVTSV-SFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVN 120 T V +GH V S ++ + + T S+DGT+K+WD+R + + +++ V Sbjct: 140 TGER--VKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVL 197 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 V + ++IS D +I++WDL +N+ T+ + D S+ LS++S+GS L + Sbjct: 198 AVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHAD-SVTGLSLSSEGSYLLSNAMD 256 Query: 181 GNCYVWEMPNHTDASHLKPVTKFRAHS--TYITRILLSSDVKHLATCSADHTARVWSIDD 238 VW++ + + H+ + R S D +A SAD VW Sbjct: 257 NTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTS 316 Query: 239 DFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDL 279 ++ L GH + + AF D +++ASSD + + ++ Sbjct: 317 R-RILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEI 356 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 54/279 (19%), Positives = 105/279 (37%), Gaps = 64/279 (22%) Query: 67 PVASFEGHRGNVTSVSFQQ----------------------------------------- 85 P+ GH G V F Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHY 117 Query: 86 --DNRWMVTSSEDGTIKVWDVRSPS-IPRNYKHNAPVNEVVIHP-NQGELISC--DRDGN 139 D + ++S D T+ VWD + + R H + VN +P +G + C DG Sbjct: 118 NTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSC--YPARRGPQLVCTGSDDGT 175 Query: 140 IRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKP 199 +++WD+ + T ++ + +++ + + + VW++ + K Sbjct: 176 VKLWDIRKKAAIQ--TFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQN------KL 227 Query: 200 VTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQ-------RW 252 R H+ +T + LSS+ +L + + D+T RVW + E + Q + Sbjct: 228 TYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKN 287 Query: 253 VWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGH 291 + C++S D + + S+D +V +WD ++R I+ + GH Sbjct: 288 LLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGH 326 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 42/188 (22%), Positives = 80/188 (42%), Gaps = 9/188 (4%) Query: 115 HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSML 174 H V HPN L S D I +W++ + + ++ L +DGSML Sbjct: 65 HEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSML 124 Query: 175 AAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLA-TCSADHTARV 233 +A+T VW D+ + V + + H++++ + L T S D T ++ Sbjct: 125 FSASTDKTVAVW------DSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKL 178 Query: 234 WSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHK 293 W I ++T + +Q V F+ S +++ D+ +++WDL ++ GH Sbjct: 179 WDIRKKAAIQTFQNTYQ--VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHAD 236 Query: 294 GAVCVALN 301 ++L+ Sbjct: 237 SVTGLSLS 244 Score = 31.2 bits (69), Expect = 0.63, Method: Compositional matrix adjust. Identities = 25/109 (22%), Positives = 51/109 (46%), Gaps = 9/109 (8%) Query: 5 LVSAGYDHTIRFWE----ALTGVCSRTIQHS----DSQVNRLEITNDKKLLATAGHQNVR 56 L+S D+T+R W+ A C + Q + + + R + D +A AG + Sbjct: 250 LLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIA-AGSADRF 308 Query: 57 LYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVR 105 +Y TT+ + GH G++ V+F D ++++S D + + +++ Sbjct: 309 VYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357 >2H9P-A nrPDB Length = 329 Score = 87.4 bits (215), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 59/227 (25%), Positives = 114/227 (50%), Gaps = 13/227 (5%) Query: 70 SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQ 128 + GH+ ++ V++ D+ +V++S+D T+K+WDV S + K H+ V +P Sbjct: 77 TISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS 136 Query: 129 GELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEM 188 ++S D ++RIWD+ +C L P + ++ DGS++ +++ G C +W+ Sbjct: 137 NLIVSGSFDESVRIWDVKTGKCLKTL-PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 195 Query: 189 PNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDG 248 AS T + ++ + S + K++ + D+T ++W K T G Sbjct: 196 -----ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG-KCLKTYTG 249 Query: 249 HQRWVWDCAFSADSA----YLVTASSDHYVRLWDLSTREIVRQYGGH 291 H+ + C F+ S ++V+ S D+ V +W+L T+EIV++ GH Sbjct: 250 HKNEKY-CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 295 Score = 83.2 bits (204), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 57/261 (21%), Positives = 109/261 (41%), Gaps = 16/261 (6%) Query: 49 TAGHQNVRLYDIRTTNPNPVA-------SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKV 101 ++G +N+ ++ P PV + GH V+SV F + W+ +SS D IK+ Sbjct: 8 SSGRENLYFQGTQS-KPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKI 66 Query: 102 WDVRSPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDT 160 W + H +++V + L+S D ++IWD+ +C L + Sbjct: 67 WGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNY 126 Query: 161 SLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVK 220 + +++ + + + +W D K + AHS ++ + + D Sbjct: 127 VF-CCNFNPQSNLIVSGSFDESVRIW------DVKTGKCLKTLPAHSDPVSAVHFNRDGS 179 Query: 221 HLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLS 280 + + S D R+W L+T +D V FS + Y++ A+ D+ ++LWD S Sbjct: 180 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS 239 Query: 281 TREIVRQYGGHHKGAVCVALN 301 + ++ Y GH C+ N Sbjct: 240 KGKCLKTYTGHKNEKYCIFAN 260 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 54/243 (22%), Positives = 106/243 (43%), Gaps = 15/243 (6%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGH-QNVRLYDI 60 S +LVSA D T++ W+ +G C +T++ + V L+ + ++VR++D+ Sbjct: 94 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 153 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY--KHNAP 118 +T + + H V++V F +D +V+SS DG ++WD S + N P Sbjct: 154 KTG--KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 211 Query: 119 VNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMAS--DGSMLAA 176 V+ V PN +++ D +++WD + +C T + + S G + + Sbjct: 212 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 271 Query: 177 ANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYI--TRILLSSDVKHLATCSADHTARVW 234 + Y+W + + V K + H+ + T + ++ A D T ++W Sbjct: 272 GSEDNLVYIWNLQTK------EIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 325 Query: 235 SID 237 D Sbjct: 326 KSD 328 >5M25-A nrPDB Length = 434 Score = 87.0 bits (214), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 59/227 (25%), Positives = 114/227 (50%), Gaps = 13/227 (5%) Query: 70 SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQ 128 + GH+ ++ V++ D+ +V++S+D T+K+WDV S + K H+ V +P Sbjct: 182 TISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS 241 Query: 129 GELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEM 188 ++S D ++RIWD+ +C L P + ++ DGS++ +++ G C +W+ Sbjct: 242 NLIVSGSFDESVRIWDVKTGKCLKTL-PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 300 Query: 189 PNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDG 248 AS T + ++ + S + K++ + D+T ++W K T G Sbjct: 301 -----ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG-KCLKTYTG 354 Query: 249 HQRWVWDCAFSADSA----YLVTASSDHYVRLWDLSTREIVRQYGGH 291 H+ + C F+ S ++V+ S D+ V +W+L T+EIV++ GH Sbjct: 355 HKNEKY-CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 400 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 55/247 (22%), Positives = 102/247 (41%), Gaps = 15/247 (6%) Query: 63 TNPNPVA-------SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK- 114 + P PV + GH V+SV F + W+ +SS D IK+W + Sbjct: 126 SKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG 185 Query: 115 HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSML 174 H +++V + L+S D ++IWD+ +C L + + +++ Sbjct: 186 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVF-CCNFNPQSNLI 244 Query: 175 AAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVW 234 + + + +W D K + AHS ++ + + D + + S D R+W Sbjct: 245 VSGSFDESVRIW------DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 298 Query: 235 SIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKG 294 L+T +D V FS + Y++ A+ D+ ++LWD S + ++ Y GH Sbjct: 299 DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE 358 Query: 295 AVCVALN 301 C+ N Sbjct: 359 KYCIFAN 365 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 54/243 (22%), Positives = 106/243 (43%), Gaps = 15/243 (6%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGH-QNVRLYDI 60 S +LVSA D T++ W+ +G C +T++ + V L+ + ++VR++D+ Sbjct: 199 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 258 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY--KHNAP 118 +T + + H V++V F +D +V+SS DG ++WD S + N P Sbjct: 259 KTG--KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 316 Query: 119 VNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMAS--DGSMLAA 176 V+ V PN +++ D +++WD + +C T + + S G + + Sbjct: 317 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 376 Query: 177 ANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYI--TRILLSSDVKHLATCSADHTARVW 234 + Y+W + + V K + H+ + T + ++ A D T ++W Sbjct: 377 GSEDNLVYIWNLQTK------EIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 430 Query: 235 SID 237 D Sbjct: 431 KSD 433 >5FL8-q nrPDB Length = 515 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 80/336 (23%), Positives = 143/336 (42%), Gaps = 58/336 (17%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQN-VRLYDIRTT 63 +V+ D+T R W+ T T++ + V + + D +++AT N +RL+D ++ Sbjct: 159 MVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSG 218 Query: 64 NPNPVASFEGHRGNVTSVSFQQ-------DNRWMVTSSEDGTIKVWDVRSPSIPRNYKHN 116 A GH +TS+S++ + +SS+DGTIK+WD S Y + Sbjct: 219 QCLGDA-LRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVC--QYTMS 275 Query: 117 APVNEV--VIHPNQGELISCDRDGNIRIWDL-GENQCTHQL------------------- 154 N V V QG L S D +R+WD+ + +C + L Sbjct: 276 GHTNSVSCVKWGGQGLLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSLSTDYALR 335 Query: 155 ------------TPED--DTSLQSLSM-----ASDGSMLAAANTKGNCYVWEMPNHTDAS 195 TPE+ +L++ + M+ A+ ++W T Sbjct: 336 IGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKST--- 392 Query: 196 HLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWD 255 KP+ + H + + S D +++ + S D++ ++W D K +T GH V+ Sbjct: 393 --KPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWD-GRDGKFISTFRGHVASVYQ 449 Query: 256 CAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGH 291 A+S+D LV+ S D +++WD+ TR++ GH Sbjct: 450 VAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDLPGH 485 Score = 67.4 bits (163), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 63/278 (22%), Positives = 118/278 (42%), Gaps = 20/278 (7%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTN 64 L S+ D TI+ W+ ++ VC T+ + V+ ++ L + + + VR++DI + Sbjct: 251 LASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQGLLYSGSHDRTVRVWDINSQG 310 Query: 65 PNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVI 124 + + H V +S D + + + K PS P + A N I Sbjct: 311 -RCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKK------PSTPEEAQKKALENYEKI 363 Query: 125 HPNQGE----LISCDRDGNIRIWD-LGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANT 179 G +++ D + +W+ L + ++T + ++ + DG + +A+ Sbjct: 364 CKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKL-VNHVAFSPDGRYIVSASF 422 Query: 180 KGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDD 239 + +W D K ++ FR H + ++ SSD + L +CS D T +VW + Sbjct: 423 DNSIKLW------DGRDGKFISTFRGHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTR 476 Query: 240 FKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 KL L GH+ V+ +S D + + D VRLW Sbjct: 477 -KLSVDLPGHKDEVYTVDWSVDGKRVCSGGKDKMVRLW 513 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 41/144 (28%), Positives = 74/144 (51%), Gaps = 7/144 (4%) Query: 4 ILVSAGYDHTIRFWEAL--TGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQN-VRLYDI 60 ++V+A D+T+ W L T +R H VN + + D + + +A N ++L+D Sbjct: 373 MMVTASDDYTMFLWNPLKSTKPIARMTGH-QKLVNHVAFSPDGRYIVSASFDNSIKLWDG 431 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPV 119 R + +++F GH +V V++ D R +V+ S+D T+KVWDVR+ + + H V Sbjct: 432 R--DGKFISTFRGHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDLPGHKDEV 489 Query: 120 NEVVIHPNQGELISCDRDGNIRIW 143 V + + S +D +R+W Sbjct: 490 YTVDWSVDGKRVCSGGKDKMVRLW 513 Score = 48.5 bits (114), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 31/87 (35%), Positives = 47/87 (54%), Gaps = 6/87 (6%) Query: 197 LKPVTKFR-AHSTYITRILLSSDVKH----LATCSADHTARVWSIDDDFKLETTLDGHQR 251 +KPVT+ A + + + IL S+ H + T + D+TAR+W D + TL GH Sbjct: 129 VKPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMH-TLKGHYN 187 Query: 252 WVWDCAFSADSAYLVTASSDHYVRLWD 278 WV ++S D + T S D+ +RLWD Sbjct: 188 WVLCVSWSPDGEVIATGSMDNTIRLWD 214 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 26/107 (24%), Positives = 45/107 (42%), Gaps = 7/107 (6%) Query: 199 PVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAF 258 P+ + H ++ + S D + +AT S D+T R+W L L GH +W+ ++ Sbjct: 178 PMHTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSW 237 Query: 259 S-------ADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCV 298 L ++S D +++WD +R GH CV Sbjct: 238 EPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMSGHTNSVSCV 284 Score = 34.3 bits (77), Expect = 0.075, Method: Compositional matrix adjust. Identities = 25/97 (25%), Positives = 46/97 (47%), Gaps = 7/97 (7%) Query: 210 ITRILLSSDVKHLATCSADHTARVWSIDDDFKLE------TTLDGHQRWVWDCAFSA-DS 262 IT L SS +K + D +++ FK++ + + GH + AF+ S Sbjct: 97 ITDNLYSSLIKPGYNSTEDQITLLYTPRAVFKVKPVTRSSSAIAGHGSTILCSAFAPHTS 156 Query: 263 AYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVA 299 + +VT + D+ R+WD T+ + GH+ +CV+ Sbjct: 157 SRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVS 193 >5I2T-A nrPDB Length = 742 Score = 77.0 bits (188), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 58/233 (24%), Positives = 104/233 (44%), Gaps = 27/233 (11%) Query: 71 FEGHR------GNVTSVSFQQDNRWMVTSSEDGT---------IKVWD-VRSPSIPRNYK 114 F+GH N+ ++Q N +T S+DG + V+D + + S Y+ Sbjct: 22 FQGHMKSDFKFSNLLGTVYRQGN---ITFSDDGKQLLSPVGNRVSVFDLINNKSFTFEYE 78 Query: 115 HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSML 174 H + + ++ LIS D DG + + H ++ S ++ + DG + Sbjct: 79 HRKNIAAIDLNKQGTLLISIDEDGRAILVNFKARNVLHHFNFKEKCS--AVKFSPDGRLF 136 Query: 175 AAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTY---ITRILLSSDVKHLATCSADHTA 231 A A+ + +W+ P+ P + R H+ + IT + S D + + T S D +A Sbjct: 137 ALASGR-FLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSA 195 Query: 232 RVWSIDDDFK--LETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTR 282 ++WS+D + K TT +GH+ +V FS D + T S D V +W+ + R Sbjct: 196 KIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKR 248 Score = 62.4 bits (150), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 67/287 (23%), Positives = 112/287 (39%), Gaps = 39/287 (13%) Query: 46 LLATAGHQNVRLYDIRTTNPNPVAS-FEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDV 104 +L T+ + +++ + + N A+ F GHR V F D + T S+DG + VW+ Sbjct: 186 ILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEF 245 Query: 105 -RSPSIPRN---------------------------YKHNAPVNEVVIHPNQGELISCDR 136 + PS + Y + A V V HP L Sbjct: 246 TKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRLLAVGFT 305 Query: 137 DGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK-GNCYVWEMPNHTDAS 195 G R++DL + QL+ + + ++S+ G LA ++K G V+E + + Sbjct: 306 SGEFRLYDLPDFTLIQQLSMGQN-PVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSES--- 361 Query: 196 HLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWD 255 + K + H + S D + T S D +VW I F L T + H V Sbjct: 362 ---YILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCL-ATFEEHTSSVTA 417 Query: 256 CAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAV-CVALN 301 F+ + ++S D VR WDL R + G + C+A++ Sbjct: 418 VQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVD 464 Score = 60.8 bits (146), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 43/167 (25%), Positives = 74/167 (44%), Gaps = 8/167 (4%) Query: 72 EGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQGE 130 +GH + S+++ D +VT+SEDG IKVWD+ S + +H + V V Sbjct: 367 QGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQV 426 Query: 131 LISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKG-NCYVWEMP 189 + S DG +R WDL + T + L++ G ++ A + + +VW + Sbjct: 427 MFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQ 486 Query: 190 NHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI 236 + + H ++ + S + LA+ S D T R+WSI Sbjct: 487 TG------QLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSI 527 Score = 60.8 bits (146), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 56/246 (22%), Positives = 108/246 (43%), Gaps = 21/246 (8%) Query: 45 KLLA---TAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWM-VTSSEDGTIK 100 +LLA T+G RLYD+ + + + V +VS Q W+ SS+ G + Sbjct: 298 RLLAVGFTSGE--FRLYDL--PDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLL 353 Query: 101 VWDVRSPS-IPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDD 159 V++ +S S I + H N + P+ +++ DG I++WD+ C E Sbjct: 354 VYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATF-EEHT 412 Query: 160 TSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDV 219 +S+ ++ A G ++ +++ G W++ + + + + + L+ D Sbjct: 413 SSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNC-------LAVDP 465 Query: 220 KHLATCSA---DHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRL 276 C+ + VWS+ +L L GH+ V +FS +++ L +AS D +R+ Sbjct: 466 SGEVVCAGSLDNFDIHVWSVQTG-QLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRI 524 Query: 277 WDLSTR 282 W + R Sbjct: 525 WSIFGR 530 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 47/191 (24%), Positives = 82/191 (42%), Gaps = 9/191 (4%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQN-VRLYD-IRT 62 +V+A D I+ W+ +G C T + S V ++ +++ ++ VR +D IR Sbjct: 385 VVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRY 444 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNE 121 N E + N +V S ++ I VW V++ + H PV+ Sbjct: 445 RNFRTFTGTERIQFNCLAVD-PSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSC 503 Query: 122 VVIHPNQGELISCDRDGNIRIWDL-GENQCTHQLTP-EDDTSLQSLSMASDGSMLAAANT 179 + L S D IRIW + G +Q Q+ P E + + +LSM DG +A + Sbjct: 504 LSFSQENSVLASASWDKTIRIWSIFGRSQ---QVEPIEVYSDVLALSMRPDGKEVAVSTL 560 Query: 180 KGNCYVWEMPN 190 KG ++ + + Sbjct: 561 KGQISIFNIED 571 Score = 42.0 bits (97), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 32/145 (22%), Positives = 67/145 (46%), Gaps = 4/145 (2%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDS-QVNRLEITNDKKLLATAGHQNVRLYDIRT 62 ++ S+ D T+R W+ + RT ++ Q N L + +++ N ++ Sbjct: 426 VMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSV 485 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDV--RSPSIPRNYKHNAPVN 120 + + GH G V+ +SF Q+N + ++S D TI++W + RS + + + V Sbjct: 486 QTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQV-EPIEVYSDVL 544 Query: 121 EVVIHPNQGELISCDRDGNIRIWDL 145 + + P+ E+ G I I+++ Sbjct: 545 ALSMRPDGKEVAVSTLKGQISIFNI 569 >5WLC-LO nrPDB Length = 923 Score = 76.3 bits (186), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 54/215 (25%), Positives = 99/215 (46%), Gaps = 13/215 (6%) Query: 74 HRGNVTSVSFQQDNRWMVTSSEDGTIKVWD-VRSPSIPRNYKHNAPVNEVVIHPNQGELI 132 +GN+T F D + ++ S + V+D + + S Y+H + + ++ LI Sbjct: 16 RQGNIT---FSDDGKQLL-SPVGNRVSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLI 71 Query: 133 SCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHT 192 S D DG + + H ++ S ++ + DG + A A+ + +W+ P+ Sbjct: 72 SIDEDGRAILVNFKARNVLHHFNFKEKCS--AVKFSPDGRLFALASGRF-LQIWKTPDVN 128 Query: 193 DASHLKPVTKFRAHSTY---ITRILLSSDVKHLATCSADHTARVWSIDDDFK--LETTLD 247 P + R H+ + IT + S D + + T S D +A++WS+D + K TT + Sbjct: 129 KDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFN 188 Query: 248 GHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTR 282 GH+ +V FS D + T S D V +W+ + R Sbjct: 189 GHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKR 223 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 67/287 (23%), Positives = 112/287 (39%), Gaps = 39/287 (13%) Query: 46 LLATAGHQNVRLYDIRTTNPNPVAS-FEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDV 104 +L T+ + +++ + + N A+ F GHR V F D + T S+DG + VW+ Sbjct: 161 ILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEF 220 Query: 105 -RSPSIPRN---------------------------YKHNAPVNEVVIHPNQGELISCDR 136 + PS + Y + A V V HP L Sbjct: 221 TKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRLLAVGFT 280 Query: 137 DGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK-GNCYVWEMPNHTDAS 195 G R++DL + QL+ + + ++S+ G LA ++K G V+E + + Sbjct: 281 SGEFRLYDLPDFTLIQQLSMGQN-PVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSES--- 336 Query: 196 HLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWD 255 + K + H + S D + T S D +VW I F L T + H V Sbjct: 337 ---YILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCL-ATFEEHTSSVTA 392 Query: 256 CAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAV-CVALN 301 F+ + ++S D VR WDL R + G + C+A++ Sbjct: 393 VQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVD 439 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 43/167 (25%), Positives = 74/167 (44%), Gaps = 8/167 (4%) Query: 72 EGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQGE 130 +GH + S+++ D +VT+SEDG IKVWD+ S + +H + V V Sbjct: 342 QGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKRGQV 401 Query: 131 LISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKG-NCYVWEMP 189 + S DG +R WDL + T + L++ G ++ A + + +VW + Sbjct: 402 MFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQ 461 Query: 190 NHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI 236 + + H ++ + S + LA+ S D T R+WSI Sbjct: 462 TG------QLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSI 502 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 56/246 (22%), Positives = 108/246 (43%), Gaps = 21/246 (8%) Query: 45 KLLA---TAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWM-VTSSEDGTIK 100 +LLA T+G RLYD+ + + + V +VS Q W+ SS+ G + Sbjct: 273 RLLAVGFTSGE--FRLYDL--PDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLL 328 Query: 101 VWDVRSPS-IPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDD 159 V++ +S S I + H N + P+ +++ DG I++WD+ C E Sbjct: 329 VYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATF-EEHT 387 Query: 160 TSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDV 219 +S+ ++ A G ++ +++ G W++ + + + + + L+ D Sbjct: 388 SSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNC-------LAVDP 440 Query: 220 KHLATCSA---DHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRL 276 C+ + VWS+ +L L GH+ V +FS +++ L +AS D +R+ Sbjct: 441 SGEVVCAGSLDNFDIHVWSVQTG-QLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRI 499 Query: 277 WDLSTR 282 W + R Sbjct: 500 WSIFGR 505 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 46/238 (19%), Positives = 95/238 (39%), Gaps = 55/238 (23%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTN 64 +V+A D I+ W+ +G C Sbjct: 360 VVTASEDGKIKVWDITSGFC---------------------------------------- 379 Query: 65 PNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPV--NEV 122 +A+FE H +VT+V F + + M +SS DGT++ WD+ R + + N + Sbjct: 380 ---LATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCL 436 Query: 123 VIHPNQGELISCDRDGN--IRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 + P+ GE++ N I +W + Q L+ + + LS + + S+LA+A+ Sbjct: 437 AVDPS-GEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEG-PVSCLSFSQENSVLASASWD 494 Query: 181 GNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDD 238 +W + + ++P+ + + + + + D K +A + +++I+D Sbjct: 495 KTIRIWSIFGRS--QQVEPIEVY----SDVLALSMRPDGKEVAVSTLKGQISIFNIED 546 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 32/145 (22%), Positives = 67/145 (46%), Gaps = 4/145 (2%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDS-QVNRLEITNDKKLLATAGHQNVRLYDIRT 62 ++ S+ D T+R W+ + RT ++ Q N L + +++ N ++ Sbjct: 401 VMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSV 460 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDV--RSPSIPRNYKHNAPVN 120 + + GH G V+ +SF Q+N + ++S D TI++W + RS + + + V Sbjct: 461 QTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQV-EPIEVYSDVL 519 Query: 121 EVVIHPNQGELISCDRDGNIRIWDL 145 + + P+ E+ G I I+++ Sbjct: 520 ALSMRPDGKEVAVSTLKGQISIFNI 544 >5WYJ-BC nrPDB Length = 817 Score = 76.3 bits (186), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 61/247 (24%), Positives = 107/247 (43%), Gaps = 26/247 (10%) Query: 65 PNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS-----IPRNYKHNAPV 119 P V +EGH + S+ +D W+ T+S+D T VW S + H+A V Sbjct: 378 PLDVEIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAV 437 Query: 120 NEV----VIHPNQGE-LISCDRDGNIRIW---------DLGENQCTHQLTPEDDTSLQSL 165 V ++ E L++ D I+ W D+ + + + + +L Sbjct: 438 TAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINAL 497 Query: 166 SMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATC 225 S++ + S+ A A+ C +W + N + L H + + K LAT Sbjct: 498 SVSPNDSIFATASYDKTCKIWNLENGELEATLA------NHKRGLWDVSFCQYDKLLATS 551 Query: 226 SADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIV 285 S D T ++WS+D F + TL+GH V C+F L++ +D +++WD S+ E + Sbjct: 552 SGDKTVKIWSLDT-FSVMKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWDCSSGECL 610 Query: 286 RQYGGHH 292 + GH+ Sbjct: 611 KTLDGHN 617 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 59/262 (22%), Positives = 104/262 (39%), Gaps = 27/262 (10%) Query: 35 VNRLEITNDKKLLATAGHQNVRL---YDIRTTNPNPVASFEGHRGNVTSVSF-----QQD 86 +N L+ T D +ATA N + Y+ + + A + GH VT+V + Sbjct: 391 LNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPNIVSKGY 450 Query: 87 NRWMVTSSEDGTIKVWDVRSPSIPRNYK-----------HNAPVNEVVIHPNQGELISCD 135 +++T+S D TIK W + P+ + + H +N + + PN + Sbjct: 451 PEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDSIFATAS 510 Query: 136 RDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDAS 195 D +IW+L EN L +S +LA ++ +W + + Sbjct: 511 YDKTCKIWNL-ENGELEATLANHKRGLWDVSFCQYDKLLATSSGDKTVKIWSLDTFSVMK 569 Query: 196 HLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWD 255 L+ H+ + R + K L +C AD ++W L+T LDGH +W Sbjct: 570 TLE------GHTNAVQRCSFINKQKQLISCGADGLIKIWDCSSGECLKT-LDGHNNRLWA 622 Query: 256 CAFSADSAYLVTASSDHYVRLW 277 + D +V+A +D + W Sbjct: 623 LSTMNDGDMIVSADADGVFQFW 644 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 76/378 (20%), Positives = 131/378 (34%), Gaps = 91/378 (24%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEIT----NDK---KLLATAGHQNVR 56 +L S + ++ W+ + C T+Q S V L+I ND+ LL+ + Sbjct: 162 LLASGDTNGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIIN 221 Query: 57 LYDIRTTNPNPVASFEGHRGNVTSVSFQQD---NRWMVTSSEDGTIKVWDVRSPSIPRNY 113 L+D + V S F +D R + T+ D ++ D S S+ + Sbjct: 222 LWDFNMKKKCKLLKTLPVNQQVESCGFLKDGDGKRIIYTAGGDAIFQLIDSESGSVLK-- 279 Query: 114 KHNAPVNEV----------------VIHPNQGELISCDRD---------------GN--- 139 + N P+ E+ V+ +LI+ + D GN Sbjct: 280 RTNKPIEELFIIGVLPILSNSQMFLVLSDQTLQLINVEEDLKNDEDTIQVTSSIAGNHGI 339 Query: 140 ----------IRIWDLGENQCTHQLTPEDDTS-------------------LQSLSMASD 170 + L N + ++ P D S L SL D Sbjct: 340 IADMRYVGPELNKLALATNSPSLRIIPVPDLSGPEASLPLDVEIYEGHEDLLNSLDATED 399 Query: 171 GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDV-----KHLATC 225 G +A A+ VW + ++ K+ HS +T + L + V + L T Sbjct: 400 GLWIATASKDNTAIVWRY--NENSCKFDIYAKYIGHSAAVTAVGLPNIVSKGYPEFLLTA 457 Query: 226 SADHTARVWSIDD-----DFKL----ETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRL 276 S D T + W I D ++ E T H++ + + S + + TAS D ++ Sbjct: 458 SNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDSIFATASYDKTCKI 517 Query: 277 WDLSTREIVRQYGGHHKG 294 W+L E+ H +G Sbjct: 518 WNLENGELEATLANHKRG 535 Score = 33.5 bits (75), Expect = 0.11, Method: Compositional matrix adjust. Identities = 33/145 (22%), Positives = 66/145 (45%), Gaps = 22/145 (15%) Query: 25 SRTIQHS-----DSQVNRLEITNDKKLLATAGH-QNVRLYDIRTTNPNPVASFEGHRGNV 78 SR I H + ++ L++T D + L Q ++++ ++T V S + + Sbjct: 49 SRKILHKISNEDEQEITALKLTPDGQYLTYVSQAQLLKIFHLKTGKV--VRSMK-----I 101 Query: 79 TSVSFQQD----NRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGE--- 130 +S S+ D + + DG+I V D+ + I ++K H ++ + + Sbjct: 102 SSPSYILDADSTSTLLAVGGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIW 161 Query: 131 -LISCDRDGNIRIWDLGENQCTHQL 154 L S D +G +++WDL + +C H L Sbjct: 162 LLASGDTNGMVKVWDLVKRKCLHTL 186 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 14/51 (27%), Positives = 27/51 (52%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNV 55 L+S G D I+ W+ +G C +T+ ++++ L ND ++ +A V Sbjct: 590 LISCGADGLIKIWDCSSGECLKTLDGHNNRLWALSTMNDGDMIVSADADGV 640 Score = 29.3 bits (64), Expect = 2.3, Method: Compositional matrix adjust. Identities = 37/171 (21%), Positives = 68/171 (39%), Gaps = 18/171 (10%) Query: 129 GELISCDRDGNIRIWDL--GENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVW 186 G++++ I I DL G + H+++ ED+ + +L + DG L + ++ Sbjct: 29 GKILATPVLDEINIIDLTPGSRKILHKISNEDEQEITALKLTPDGQYLTYVSQAQLLKIF 88 Query: 187 EMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKH--LATCSADHTARVWSIDDDFKLET 244 HLK R+ +L +D LA D + V I++ + + Sbjct: 89 ---------HLKTGKVVRSMKISSPSYILDADSTSTLLAVGGTDGSIIVVDIENGY-ITH 138 Query: 245 TLDGHQRWVWDCAF--SADSAYLVTASSD--HYVRLWDLSTREIVRQYGGH 291 + GH + F +S + AS D V++WDL R+ + H Sbjct: 139 SFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQEH 189 >4V8M-A7 nrPDB Length = 318 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 52/233 (22%), Positives = 108/233 (46%), Gaps = 14/233 (6%) Query: 67 PVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIH 125 P EGH V+ V+ + + V++S D ++++W++++ + H V V Sbjct: 59 PDRRLEGHSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFS 118 Query: 126 PNQGELISCDRDGNIRIWDLGENQCTHQLTP---EDDTSLQSLSMASDGSMLAAANTKGN 182 P+ +++S RD +R+W++ + +C H L+ D S S + D ++ + Sbjct: 119 PDNRQIVSGGRDNALRVWNV-KGECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNL 177 Query: 183 CYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKL 242 VW++ + VT + H+ Y+T + +S D A+ D AR+W + L Sbjct: 178 VKVWDLATG------RLVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEAL 231 Query: 243 ETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGA 295 G + FS + Y + A+++ +R++DL ++I+ + H+G+ Sbjct: 232 SEMAAGAP--INQICFSPNR-YWMCAATEKGIRIFDLENKDIIVELAPEHQGS 281 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 54/193 (27%), Positives = 89/193 (46%), Gaps = 15/193 (7%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQ---HSD-SQVNRLEITNDKKLLATAGHQN-VRLYD 59 +VS G D+ +R W + G C T+ H+D R + D ++ + G N V+++D Sbjct: 124 IVSGGRDNALRVWN-VKGECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWD 182 Query: 60 IRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPV 119 + T V +GH VTSV+ D +S +DG ++WD+ AP+ Sbjct: 183 LATGRL--VTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPI 240 Query: 120 NEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQ------SLSMASDGSM 173 N++ PN+ + + G IRI+DL +L PE S + S++ ++DGS Sbjct: 241 NQICFSPNRYWMCAATEKG-IRIFDLENKDIIVELAPEHQGSKKIVPECVSIAWSADGST 299 Query: 174 LAAANTKGNCYVW 186 L + T VW Sbjct: 300 LYSGYTDNVIRVW 312 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 66/297 (22%), Positives = 139/297 (46%), Gaps = 33/297 (11%) Query: 5 LVSAGYDHTIRFW---------EALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQN 54 +VS D T+ W E G+ R ++ + V+ + ++N+ +A + Sbjct: 31 VVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSAFVSDVALSNNGNFAVSASWDHS 90 Query: 55 VRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSP---SIPR 111 +RL++++ N F GH +V SV+F DNR +V+ D ++VW+V+ ++ R Sbjct: 91 LRLWNLQ--NGQCQYKFLGHTKDVLSVAFSPDNRQIVSGGRDNALRVWNVKGECMHTLSR 148 Query: 112 NYKHNAPVNEVVIHP--NQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMAS 169 H V+ V P + ++S D +++WDL + L + + S++++ Sbjct: 149 G-AHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGRLVTDLKGHTNY-VTSVTVSP 206 Query: 170 DGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADH 229 DGS+ A+++ G +W++ S + A I +I S + ++ + + Sbjct: 207 DGSLCASSDKDGVARLWDLTKGEALSEM-------AAGAPINQICFSPN-RYWMCAATEK 258 Query: 230 TARVWSIDDD---FKLETTLDGHQRWVWDC---AFSADSAYLVTASSDHYVRLWDLS 280 R++ +++ +L G ++ V +C A+SAD + L + +D+ +R+W +S Sbjct: 259 GIRIFDLENKDIIVELAPEHQGSKKIVPECVSIAWSADGSTLYSGYTDNVIRVWGVS 315 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 59/249 (23%), Positives = 106/249 (42%), Gaps = 23/249 (9%) Query: 69 ASFEGHRGNVTSVSFQQDNRW---MVTSSEDGTIKVWDVR--------SPSIP--RNYKH 115 GHRG VTS++ Q +V++S D T+ W S +P R H Sbjct: 7 GQLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGH 66 Query: 116 NAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLA 175 +A V++V + N +S D ++R+W+L QC ++ L S++ + D + Sbjct: 67 SAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVL-SVAFSPDNRQIV 125 Query: 176 AANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYIT--RILLSSDVKHLATCSADHTARV 233 + VW + + +++ AH+ +++ R S D + + D+ +V Sbjct: 126 SGGRDNALRVWNVKGEC----MHTLSR-GAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKV 180 Query: 234 WSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQY-GGHH 292 W + +L T L GH +V S D + ++ D RLWDL+ E + + G Sbjct: 181 WDLATG-RLVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAP 239 Query: 293 KGAVCVALN 301 +C + N Sbjct: 240 INQICFSPN 248 Score = 43.1 bits (100), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 36/154 (23%), Positives = 67/154 (43%), Gaps = 13/154 (8%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNV-RLYDIRT 62 ++VS G+D+ ++ W+ TG ++ + V + ++ D L A++ V RL+D+ Sbjct: 168 VIVSGGWDNLVKVWDLATGRLVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDL-- 225 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSI-----PRNYKHNA 117 S + + F + WM ++E G I+++D+ + I P + Sbjct: 226 -TKGEALSEMAAGAPINQICFSPNRYWMCAATEKG-IRIFDLENKDIIVELAPEHQGSKK 283 Query: 118 PVNEVVI---HPNQGELISCDRDGNIRIWDLGEN 148 V E V + L S D IR+W + EN Sbjct: 284 IVPECVSIAWSADGSTLYSGYTDNVIRVWGVSEN 317 >6G51-g nrPDB Length = 317 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 72/296 (24%), Positives = 133/296 (44%), Gaps = 31/296 (10%) Query: 4 ILVSAGYDHTIRFW-----EALTGVCSRTIQHSDSQVNRLEITNDKKL-LATAGHQNVRL 57 +++SA D TI W E G+ R ++ V+ + I++D + L+ + +RL Sbjct: 30 MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRL 89 Query: 58 YDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRS--PSIPRNYKH 115 +D+ T F GH +V SV+F DNR +V+ S D TIK+W+ ++ H Sbjct: 90 WDL--TTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESH 147 Query: 116 NAPVNEVVIHPNQGE--LISCDRDGNIRIWDLGENQCTHQLTPEDDTS-LQSLSMASDGS 172 + V+ V PN ++SC D +++W+L C + T L +++++ DGS Sbjct: 148 SEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA--NCKLKTNHIGHTGYLNTVTVSPDGS 205 Query: 173 MLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTAR 232 + A+ G +W++ + HL + I L S ++ + + + Sbjct: 206 LCASGGKDGQAMLWDL---NEGKHL-----YTLDGGDIINALCFSPNRYWLCAATGPSIK 257 Query: 233 VWSID-----DDFKLETTLDGHQRWVWDC---AFSADSAYLVTASSDHYVRLWDLS 280 +W ++ D+ K E + C A+SAD L +D+ VR+W ++ Sbjct: 258 IWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVT 313 Score = 53.1 bits (126), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 42/185 (22%), Positives = 82/185 (44%), Gaps = 15/185 (8%) Query: 115 HNAPVNEVVIHPNQGELI-SCDRDGNIRIWDLGENQCTHQLTPEDDTSLQS-----LSMA 168 HN V ++ P ++I S RD I +W L ++ + + P+ S + ++ Sbjct: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGI-PQRALRGHSHFVSDVVIS 72 Query: 169 SDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSAD 228 SDG + + G +W++ T +F H+ + + SSD + + + S D Sbjct: 73 SDGQFALSGSWDGTLRLWDLTTGTTTR------RFVGHTKDVLSVAFSSDNRQIVSGSRD 126 Query: 229 HTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSA--YLVTASSDHYVRLWDLSTREIVR 286 T ++W+ K + H WV FS +S+ +V+ D V++W+L+ ++ Sbjct: 127 KTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT 186 Query: 287 QYGGH 291 + GH Sbjct: 187 NHIGH 191 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 29/104 (27%), Positives = 53/104 (50%), Gaps = 5/104 (4%) Query: 203 FRAHSTYITRILLSSDVKHLA-TCSADHTARVWSIDDD---FKL-ETTLDGHQRWVWDCA 257 + H+ ++T+I + + + S D T +W + D + + + L GH +V D Sbjct: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70 Query: 258 FSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 S+D + ++ S D +RLWDL+T R++ GH K + VA + Sbjct: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFS 114 >3JB9-L nrPDB Length = 340 Score = 74.3 bits (181), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 65/280 (23%), Positives = 118/280 (42%), Gaps = 8/280 (2%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHS-DSQVNRLEITNDKKLLATAGHQNVRLYDIRTT 63 S G D I W V + + + + L+ + D +++ + + L Sbjct: 65 FASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQWSRDSRVVYCSS-SDTHLMSWDAV 123 Query: 64 NPNPVASFEGHRGNVTSVSFQQDNRWMVTS-SEDGTIKVWDVRSPSIPRNYKHNAPVNEV 122 + + +GH G V ++ + ++TS S+D T+KVWD RS + + P+ V Sbjct: 124 SGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRSKDCIKTIEEKYPLTAV 183 Query: 123 VIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGN 182 I ++ DG I+IWDL N C+H L D + SL+++ DGS L + + Sbjct: 184 AIAQQGTQVFIGGIDGAIKIWDLRNNHCSHVLKGHKDI-ITSLAISKDGSSLLSNSMDNT 242 Query: 183 CYVWEMPNHTDASHLKPVTKFRAHSTY--ITRILLSSDVKHLATCSADHTARVWSIDDDF 240 ++++ A + + H + + S + + + S+D VWS D Sbjct: 243 VRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVWSATGD- 301 Query: 241 KLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLS 280 L L GH+ V F +++ SSD + L +L+ Sbjct: 302 -LRYVLPGHEGSVNHVDFHPHQDIILSCSSDRTIFLGELN 340 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 22/104 (21%), Positives = 54/104 (51%), Gaps = 2/104 (1%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIR 61 S +L S D T++ W++ + C +TI+ ++ ++++D+R Sbjct: 148 SELLTSVSDDCTMKVWDSRSKDCIKTIEEKYPLTAVAIAQQGTQVFIGGIDGAIKIWDLR 207 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVR 105 + + V +GH+ +TS++ +D ++++S D T++++DV+ Sbjct: 208 NNHCSHV--LKGHKDIITSLAISKDGSSLLSNSMDNTVRIFDVK 249 Score = 36.6 bits (83), Expect = 0.012, Method: Compositional matrix adjust. Identities = 21/93 (22%), Positives = 42/93 (45%) Query: 199 PVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAF 258 P + H+ + + A+ D +W++ D K L+G + + D + Sbjct: 42 PNLQMFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQW 101 Query: 259 SADSAYLVTASSDHYVRLWDLSTREIVRQYGGH 291 S DS + +SSD ++ WD + + +R++ GH Sbjct: 102 SRDSRVVYCSSSDTHLMSWDAVSGQKIRKHKGH 134 >6F3T-A nrPDB Length = 608 Score = 74.3 bits (181), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 69/285 (24%), Positives = 119/285 (41%), Gaps = 64/285 (22%) Query: 5 LVSAGY-DHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTT 63 L++ G+ D T+R W ++T R+++ + S ++ ++ +D L R+ D +T Sbjct: 292 LIAGGFADSTVRVW-SVTPKKLRSVKQA-SDLSLIDKESDDVL--------ERIMDEKTA 341 Query: 64 NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAP---- 118 + + GH G V SF D ++++SSEDGT+++W +++ + YK HN P Sbjct: 342 SELKI--LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDT 399 Query: 119 --------------------------------------VNEVVIHPNQGELISCDRDGNI 140 VN HPN + + D + Sbjct: 400 QFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTV 459 Query: 141 RIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPV 200 R+WD+ C T + SL+ + +G LA T G +W D H V Sbjct: 460 RLWDVLNGNCVRIFTGHKG-PIHSLTFSPNGRFLATGATDGRVLLW------DIGHGLMV 512 Query: 201 TKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFK-LET 244 + + H+ + + S D + LA+ S D+T R+W F+ LET Sbjct: 513 GELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLET 557 Score = 54.3 bits (129), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 44/161 (27%), Positives = 68/161 (42%), Gaps = 19/161 (11%) Query: 137 DGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASH 196 D +R+W +TP+ L+S+ ASD S++ + + + + + + AS Sbjct: 299 DSTVRVW---------SVTPK---KLRSVKQASDLSLI---DKESDDVLERIMDEKTASE 343 Query: 197 LKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDC 256 LK + HS + S D +L + S D T R+WS+ F GH VWD Sbjct: 344 LKILY---GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQT-FTCLVGYKGHNYPVWDT 399 Query: 257 AFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVC 297 FS Y V+ D RLW + +R + GH C Sbjct: 400 QFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNC 440 Score = 53.1 bits (126), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 62/282 (21%), Positives = 104/282 (36%), Gaps = 68/282 (24%) Query: 18 EALTGVCSRTIQHSDSQVNRLEITNDKKLLATA-GHQNVRLYDIRTTNPNPVASFEGHRG 76 + L +C T ++ + +++T+D L+A VR++ + Sbjct: 264 DCLPSICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKK------------ 311 Query: 77 NVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS-IPRNYKHNAPVNEVVIHPNQGELISCD 135 + SV D + S+D ++ D ++ S + Y H+ PV P++ L+S Sbjct: 312 -LRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSS 370 Query: 136 RDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCY-VWEMPNHTDA 194 DG +R+W L C KG+ Y VW+ Sbjct: 371 EDGTVRLWSLQTFTCL-------------------------VGYKGHNYPVWD------- 398 Query: 195 SHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVW 254 T+F + Y + D AR+W+ D ++ GH V Sbjct: 399 ------TQFSPYGYY------------FVSGGHDRVARLWATDH-YQPLRIFAGHLADVN 439 Query: 255 DCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAV 296 F +S Y+ T S+D VRLWD+ VR + G HKG + Sbjct: 440 CTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTG-HKGPI 480 >6HHQ-h nrPDB Length = 319 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 71/298 (23%), Positives = 132/298 (44%), Gaps = 32/298 (10%) Query: 4 ILVSAGYDHTIRFWEALTG------VCSRTIQHSDSQVNRLEITNDKKL-LATAGHQNVR 56 +L+SA D T+ W+ LTG V R+ + V +T D L+ + + +R Sbjct: 32 LLLSASRDKTLISWK-LTGDDQKFGVPVRSFKGHSHIVQDCTLTADGAYALSASWDKTLR 90 Query: 57 LYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHN 116 L+D+ T F GH+ +V SV + +++ S D TIKVW ++ + HN Sbjct: 91 LWDVAT--GETYQRFVGHKSDVMSVDIDKKASMIISGSRDKTIKVWTIKGQCLATLLGHN 148 Query: 117 APVNEVVIHPNQGE------LISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASD 170 V++V + PN+ +IS D ++ W+L + Q ++++ +L+ + D Sbjct: 149 DWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQIEADFIGH-NSNINTLTASPD 207 Query: 171 GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHT 230 G+++A+A G +W + K + A + + S + LA +A Sbjct: 208 GTLIASAGKDGEIMLWNLAAK------KAMYTLSAQDEVFS-LAFSPNRYWLAAATATGI 260 Query: 231 ARVWSIDDDF---KLETTLDGHQRW----VWDCAFSADSAYLVTASSDHYVRLWDLST 281 +V+S+D + L G+ + A+SAD L +D+ +R+W + T Sbjct: 261 -KVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQVMT 317 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 48/218 (22%), Positives = 85/218 (38%), Gaps = 46/218 (21%) Query: 67 PVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRS-PSIPRNYKHNAPVNEVVIH 125 PV SF+GH V + D + +++S D T+++WDV + + R H + V V I Sbjct: 57 PVRSFKGHSHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDID 116 Query: 126 PNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYV 185 +IS RD I++W + + QC L +D Sbjct: 117 KKASMIISGSRDKTIKVWTI-KGQCLATLLGHND-------------------------- 149 Query: 186 WEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETT 245 W S ++ V +A +T I + D + W+++ F++E Sbjct: 150 W-------VSQVRVVPNEKADDDSVTII----------SAGNDKMVKAWNLNQ-FQIEAD 191 Query: 246 LDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTRE 283 GH + S D + +A D + LW+L+ ++ Sbjct: 192 FIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKK 229 Score = 51.2 bits (121), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 32/104 (30%), Positives = 53/104 (50%), Gaps = 5/104 (4%) Query: 203 FRAHSTYITRILLSSDVKHLA-TCSADHTARVWSI-DDDFKLET---TLDGHQRWVWDCA 257 H+ ++T + S+ +L + S D T W + DD K + GH V DC Sbjct: 13 LEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDCT 72 Query: 258 FSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 +AD AY ++AS D +RLWD++T E +++ GH + V ++ Sbjct: 73 LTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDID 116 Score = 40.8 bits (94), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 51/238 (21%), Positives = 92/238 (38%), Gaps = 66/238 (27%) Query: 69 ASFEGHRGNVTSV--SFQQDNRWMVTSSEDGTIKVW----DVRSPSIP-RNYK-HNAPVN 120 + EGH G VTS+ S Q N ++++S D T+ W D + +P R++K H+ V Sbjct: 11 GTLEGHNGWVTSLATSAGQPNL-LLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQ 69 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 + + + +S D +R+WD+ + T+Q Sbjct: 70 DCTLTADGAYALSASWDKTLRLWDVATGE-TYQ--------------------------- 101 Query: 181 GNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDF 240 +F H + + + + + + S D T +VW+I Sbjct: 102 ---------------------RFVGHKSDVMSVDIDKKASMIISGSRDKTIKVWTIKG-- 138 Query: 241 KLETTLDGHQRWVWDCAFSA------DSAYLVTASSDHYVRLWDLSTREIVRQYGGHH 292 + TL GH WV DS +++A +D V+ W+L+ +I + GH+ Sbjct: 139 QCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQIEADFIGHN 196 Score = 37.4 bits (85), Expect = 0.008, Method: Compositional matrix adjust. Identities = 38/194 (19%), Positives = 69/194 (35%), Gaps = 51/194 (26%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIR 61 SV ++SAG D ++ W +N+ +I D Sbjct: 166 SVTIISAGNDKMVKAW----------------NLNQFQIEAD------------------ 191 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNE 121 F GH N+ +++ D + ++ +DG I +W++ + V Sbjct: 192 ---------FIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQDEVFS 242 Query: 122 VVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPE-------DDTSLQSLSMASDGSML 174 + PN+ L + G I+++ L L PE + SL+ ++DG L Sbjct: 243 LAFSPNRYWLAAATATG-IKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTL 301 Query: 175 AAANTKGNCYVWEM 188 A T VW++ Sbjct: 302 FAGYTDNVIRVWQV 315 >6MZM-G nrPDB Length = 800 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 49/185 (26%), Positives = 86/185 (46%), Gaps = 5/185 (2%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNV-RLYDIRTT 63 L+S+ D T+R W T C + + V + + + GH V RL+ T Sbjct: 558 LLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLW--ATD 615 Query: 64 NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEV 122 + P+ F GH +V F ++ ++ T S D T+++WDV + + R + H P++ + Sbjct: 616 HYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSL 675 Query: 123 VIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGN 182 PN L + DG + +WD+G +L DT + SL + DG +LA+ + Sbjct: 676 TFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDT-VCSLRFSRDGEILASGSMDNT 734 Query: 183 CYVWE 187 +W+ Sbjct: 735 VRLWD 739 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 55/216 (25%), Positives = 86/216 (39%), Gaps = 51/216 (23%) Query: 73 GHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAP------------- 118 GH G V SF D ++++SSEDGT+++W +++ + YK HN P Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYF 600 Query: 119 -----------------------------VNEVVIHPNQGELISCDRDGNIRIWDLGENQ 149 VN HPN + + D +R+WD+ Sbjct: 601 VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN 660 Query: 150 CTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTY 209 C T + SL+ + +G LA T G +W D H V + + H+ Sbjct: 661 CVRIFTGHKG-PIHSLTFSPNGRFLATGATDGRVLLW------DIGHGLMVGELKGHTDT 713 Query: 210 ITRILLSSDVKHLATCSADHTARVWSIDDDFK-LET 244 + + S D + LA+ S D+T R+W F+ LET Sbjct: 714 VCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLET 749 Score = 58.2 bits (139), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 46/183 (25%), Positives = 72/183 (39%), Gaps = 16/183 (8%) Query: 113 YKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLT----PEDDTSLQSLSMA 168 Y H+ PV P++ L+S DG +R+W L C P DT Sbjct: 540 YGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY--- 596 Query: 169 SDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSAD 228 G + +W TD H +P+ F H + + ++AT SAD Sbjct: 597 --GYYFVSGGHDRVARLWA----TD--HYQPLRIFAGHLADVNCTRFHPNSNYVATGSAD 648 Query: 229 HTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQY 288 T R+W + + GH+ + FS + +L T ++D V LWD+ +V + Sbjct: 649 RTVRLWDVLNG-NCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL 707 Query: 289 GGH 291 GH Sbjct: 708 KGH 710 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 29/93 (31%), Positives = 38/93 (40%), Gaps = 1/93 (1%) Query: 205 AHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAY 264 HS + S D +L + S D T R+WS+ F GH VWD FS Y Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQT-FTCLVGYKGHNYPVWDTQFSPYGYY 599 Query: 265 LVTASSDHYVRLWDLSTREIVRQYGGHHKGAVC 297 V+ D RLW + +R + GH C Sbjct: 600 FVSGGHDRVARLWATDHYQPLRIFAGHLADVNC 632 Score = 41.2 bits (95), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 20/47 (42%), Positives = 27/47 (57%) Query: 246 LDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHH 292 L GH V+ +FS D YL+++S D VRLW L T + Y GH+ Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHN 585 >5K1B-B nrPDB Length = 677 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 44/155 (28%), Positives = 80/155 (51%), Gaps = 9/155 (5%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRT- 62 L+SA D T++ W A G C T++ V L DK+L+A+AG + + L+D+ T Sbjct: 90 LISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTL 149 Query: 63 ------TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-H 115 N +S G++ ++ S++ Q +V+ S + ++VWD R+ + K H Sbjct: 150 TALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGH 209 Query: 116 NAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQC 150 V ++++ + + +S DG IR+W LG+ +C Sbjct: 210 TDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRC 244 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 61/262 (23%), Positives = 113/262 (43%), Gaps = 16/262 (6%) Query: 49 TAGHQNVRL-YDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDV--- 104 TAG + V++ Y IR + V + +R V ++ + T+ D I++W V Sbjct: 9 TAGRRKVQVSYVIR----DEVEKY--NRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQH 62 Query: 105 -RSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQ 163 + P I H VN++V+ N LIS D +++W+ + C L D ++ Sbjct: 63 KQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDY-VK 121 Query: 164 SLSMASDGSMLAAANTKGNCYVWE---MPNHTDASHLKPVTKFRAHSTYITRILLSSDVK 220 +L+ A D ++A+A ++W+ + T +++ + + I + ++ Sbjct: 122 ALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGT 181 Query: 221 HLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLS 280 + + S + RVW KL L GH V + D ++ SSD +RLW L Sbjct: 182 IIVSGSTEKVLRVWDPRTCAKL-MKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLG 240 Query: 281 TREIVRQYGGHHKGAVCVALND 302 + + Y H +G + +ND Sbjct: 241 QQRCIATYRVHDEGVWALQVND 262 >6Q8F-A nrPDB Length = 514 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 50/211 (23%), Positives = 89/211 (42%), Gaps = 40/211 (18%) Query: 73 GHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELI 132 G + +V F D +++VT S DG I+VW+ + I ++ K+ A N +++ Sbjct: 213 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMM-------- 264 Query: 133 SCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHT 192 D ++ + + D MLA G VW++ + Sbjct: 265 --------------------------DDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQ 298 Query: 193 DASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRW 252 + RAHS +T + S D + + S D T R+ + L+ GH + Sbjct: 299 CLRRFE-----RAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKE-FRGHSSF 352 Query: 253 VWDCAFSADSAYLVTASSDHYVRLWDLSTRE 283 V + F+ D Y+++ASSD V++W++ T E Sbjct: 353 VNEATFTQDGHYIISASSDGTVKIWNMKTTE 383 Score = 66.2 bits (160), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 36/152 (23%), Positives = 77/152 (50%), Gaps = 12/152 (7%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQ-VNRLEITNDK-KLLATAGHQNVRLYDIR 61 +L + D I+ W+ +G C R + + S+ V L + D ++L+ + Q +R++ ++ Sbjct: 279 MLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLK 338 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKH------ 115 + + F GH V +F QD +++++S DGT+K+W++++ +K Sbjct: 339 SGKT--LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAG 396 Query: 116 -NAPVNEVVIHPNQGE-LISCDRDGNIRIWDL 145 + VN V++ P E + C+R + I ++ Sbjct: 397 TDITVNSVILLPKNPEHFVVCNRSNTVVIMNM 428 Score = 57.8 bits (138), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 64/296 (21%), Positives = 121/296 (40%), Gaps = 36/296 (12%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHS--------DSQVNRLEITNDKKLLATAGHQNVR 56 LV+ D I W TG + +++ D V + + D ++LAT G Q+ + Sbjct: 230 LVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT-GAQDGK 288 Query: 57 LYDIRTTNPNPVASFE-GHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK- 114 + + + + FE H VT +SF +D+ ++++S D TI++ ++S + ++ Sbjct: 289 IKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRG 348 Query: 115 HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSML 174 H++ VNE + +IS DG ++IW++ +C++ T+ +++ S +L Sbjct: 349 HSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNS--VIL 406 Query: 175 AAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKH--LATCSADHTAR 232 N P H + I R S + C+ Sbjct: 407 LPKN----------PEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGE 456 Query: 233 -VWSIDDDF----------KLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 ++ + +DF KLE TL H++ V A + T S D ++LW Sbjct: 457 WIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 512 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 39/164 (23%), Positives = 71/164 (43%), Gaps = 14/164 (8%) Query: 138 GNIRIWDLGENQCTHQLTPE----DDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTD 193 G + D+ E + QL+ + ++ + DG L + G VW N T Sbjct: 190 GKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVW---NFTT 246 Query: 194 ASHLKPVTKFRAHSTYITR------ILLSSDVKHLATCSADHTARVWSIDDDFKLETTLD 247 K + K++A ++ + S D + LAT + D +VW I L Sbjct: 247 GKIRKDL-KYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFER 305 Query: 248 GHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGH 291 H + V +FS DS+ +++AS D +R+ L + + ++++ GH Sbjct: 306 AHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGH 349 >6HQA-B nrPDB Length = 722 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 48/197 (24%), Positives = 91/197 (46%), Gaps = 4/197 (2%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGH-QNVRLYDIRTT 63 L+S D T+R W T C + + S V ++ + ATA H Q RL+ Sbjct: 468 LISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKFSPMGHYFATASHDQTARLWSCDHI 527 Query: 64 NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEV 122 P+ F GH +V V F ++ ++ T S D T ++WD+ R + H+ +N + Sbjct: 528 --YPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTARMWDIARGECVRVFMGHSGAINCL 585 Query: 123 VIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGN 182 + P+ L S D + +WD+ + + +S+ SL+ + +G++L + + Sbjct: 586 AVSPDGRWLASAGEDSVVCLWDISTGRRIKAMRGHGRSSIYSLAFSREGTVLVSTGADNS 645 Query: 183 CYVWEMPNHTDASHLKP 199 VW++ +T++ +P Sbjct: 646 VRVWDVKKNTNSPSAQP 662 Score = 68.2 bits (165), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 67/288 (23%), Positives = 127/288 (44%), Gaps = 40/288 (13%) Query: 19 ALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQN--VRLYDI--------------RT 62 +L VC T ++++ + L+ +D ++A+ G Q+ ++L+ I Sbjct: 377 SLPSVCMYTFHNTNNDLTCLKFNDDSTMVAS-GFQDSFIKLWSIDGSPLRSLLKNDPYNQ 435 Query: 63 TNPNPVA-----SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HN 116 N + VA GH G V V F DNR++++ SED T+++W + + + +YK H+ Sbjct: 436 QNNDGVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHS 495 Query: 117 APVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTH----QLTPEDDTSLQSLSMASDGS 172 + V +V P + D R+W C H ++ + + + + Sbjct: 496 SSVWDVKFSPMGHYFATASHDQTARLW-----SCDHIYPLRIFAGHLNDVDCVEFHPNST 550 Query: 173 MLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTAR 232 L ++ +W D + + V F HS I + +S D + LA+ D Sbjct: 551 YLFTGSSDKTARMW------DIARGECVRVFMGHSGAINCLAVSPDGRWLASAGEDSVVC 604 Query: 233 VWSIDDDFKLETTLDGHQRW-VWDCAFSADSAYLVTASSDHYVRLWDL 279 +W I +++ + GH R ++ AFS + LV+ +D+ VR+WD+ Sbjct: 605 LWDISTGRRIKA-MRGHGRSSIYSLAFSREGTVLVSTGADNSVRVWDV 651 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 57/250 (22%), Positives = 98/250 (39%), Gaps = 32/250 (12%) Query: 70 SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNE-------- 121 +F ++T + F D+ + + +D IK+W + + R+ N P N+ Sbjct: 385 TFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPL-RSLLKNDPYNQQNNDGVAV 443 Query: 122 ---------------VVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLS 166 V P+ LISC D +R+W L C +S+ + Sbjct: 444 KGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHS-SSVWDVK 502 Query: 167 MASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCS 226 + G A A+ +W H+ P+ F H + + + +L T S Sbjct: 503 FSPMGHYFATASHDQTARLWS------CDHIYPLRIFAGHLNDVDCVEFHPNSTYLFTGS 556 Query: 227 ADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVR 286 +D TAR+W I + + GH + A S D +L +A D V LWD+ST ++ Sbjct: 557 SDKTARMWDIARGECVRVFM-GHSGAINCLAVSPDGRWLASAGEDSVVCLWDISTGRRIK 615 Query: 287 QYGGHHKGAV 296 GH + ++ Sbjct: 616 AMRGHGRSSI 625 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 38/127 (29%), Positives = 64/127 (50%), Gaps = 13/127 (10%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVR-LYDI 60 S L + D T R W+ G C R +N L ++ D + LA+AG +V L+DI Sbjct: 549 STYLFTGSSDKTARMWDIARGECVRVFMGHSGAINCLAVSPDGRWLASAGEDSVVCLWDI 608 Query: 61 RTTNPNPVASFEGH-RGNVTSVSFQQDNRWMVTSSEDGTIKVWDVR----SPSIPRNYKH 115 T + + GH R ++ S++F ++ +V++ D +++VWDV+ SPS Sbjct: 609 STG--RRIKAMRGHGRSSIYSLAFSREGTVLVSTGADNSVRVWDVKKNTNSPS-----AQ 661 Query: 116 NAPVNEV 122 P+N+V Sbjct: 662 PEPINDV 668 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 39/176 (22%), Positives = 74/176 (42%), Gaps = 9/176 (5%) Query: 1 MSVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEI-TNDKKLLATAGHQNVRLYD 59 M +A +D T R W R + V+ +E N L + + R++D Sbjct: 506 MGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTARMWD 565 Query: 60 IRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDV---RSPSIPRNYKHN 116 I V F GH G + ++ D RW+ ++ ED + +WD+ R R + + Sbjct: 566 I--ARGECVRVFMGHSGAINCLAVSPDGRWLASAGEDSVVCLWDISTGRRIKAMRGHGRS 623 Query: 117 APVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPE--DDTSLQSLSMASD 170 + + + L+S D ++R+WD+ +N + PE +D + Q + ++ Sbjct: 624 S-IYSLAFSREGTVLVSTGADNSVRVWDVKKNTNSPSAQPEPINDVTAQGIQKKTE 678 >5XYI-g nrPDB Length = 335 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 55/218 (25%), Positives = 100/218 (45%), Gaps = 14/218 (6%) Query: 32 DSQVNRLEITNDKKLLATAGH-QNVRLYDIRTTN---PNPVASFEGHRGNVTSVSFQQDN 87 ++ + +EI N+ L +A ++ ++ + T P GH V+ VS +D Sbjct: 33 NAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVSLSRDA 92 Query: 88 RWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQGELISCDRDGNIRIWD-L 145 ++TSS D T+++WD+ + + + + H V V P +IS RD ++IW+ L Sbjct: 93 SHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIISVGRDNQVKIWNIL 152 Query: 146 GENQCTHQLTPEDDTSLQSLSMASDGS--MLAAANTKGNCYVWEMPNHTDASHLKPVTKF 203 GEN+ Q + TS+ MA + S ++A G Y+W + K + +F Sbjct: 153 GENKAELQCSSW-VTSVACAPMADETSPLVIAVGCWDGKVYIWSIEKEA-----KLIKEF 206 Query: 204 RAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFK 241 +AH T + + D K + T +D +W ++ K Sbjct: 207 KAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGAK 244 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 36/112 (32%), Positives = 60/112 (53%), Gaps = 4/112 (3%) Query: 194 ASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETT----LDGH 249 ++H P F H+ I I + ++ +L + S D +A VW ++ + T L GH Sbjct: 20 SAHFAPRATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGH 79 Query: 250 QRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 +V D + S D+++L+T+S D +RLWDLSTR + + GH K + V + Sbjct: 80 NHFVSDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFS 131 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 33/131 (25%), Positives = 58/131 (44%), Gaps = 11/131 (8%) Query: 68 VASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPN 127 + F+ H G TSV F D +W++T D + +W + + ++ +PV+ V P Sbjct: 203 IKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGAKTISFTAPSPVHAVAACPT 262 Query: 128 QGELISCDRDGNIRIWDLGENQCTHQLTPE----------DDTSLQSLSMASDGSMLAAA 177 Q + + +G I +WD+G Q + P L+ A+DGS+L + Sbjct: 263 QAWICAATYEG-IAVWDIGAKQQIDLVQPNFKHEGKRNAGRTPDCTCLAWAADGSVLYSG 321 Query: 178 NTKGNCYVWEM 188 G+ WE+ Sbjct: 322 YNDGSIRAWEV 332 Score = 51.2 bits (121), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 30/121 (24%), Positives = 64/121 (52%), Gaps = 2/121 (1%) Query: 159 DTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSD 218 + +++S+ + ++ + L +A+ + VW++ N T P T+ H+ +++ + LS D Sbjct: 33 NAAIESIEIDNEHNYLVSASRDKSALVWKL-NRTQEQWATPFTRLIGHNHFVSDVSLSRD 91 Query: 219 VKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWD 278 HL T S D T R+W + + L GH++ V FS + +++ D+ V++W+ Sbjct: 92 ASHLLTSSWDSTLRLWDLSTRTTKKLFL-GHKKDVLGVTFSPCNRRIISVGRDNQVKIWN 150 Query: 279 L 279 + Sbjct: 151 I 151 Score = 50.8 bits (120), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 43/222 (19%), Positives = 87/222 (39%), Gaps = 20/222 (9%) Query: 67 PVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVR------SPSIPRNYKHNAPVN 120 P A+F GH + S+ ++ ++V++S D + VW + + R HN V+ Sbjct: 25 PRATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVS 84 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 +V + + L++ D +R+WDL + T +L + ++ + + + Sbjct: 85 DVSLSRDASHLLTSSWDSTLRLWDL-STRTTKKLFLGHKKDVLGVTFSPCNRRIISVGRD 143 Query: 181 GNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKH-----LATCSADHTARVWS 235 +W + A S+++T + + +A D +WS Sbjct: 144 NQVKIWNILGENKAE--------LQCSSWVTSVACAPMADETSPLVIAVGCWDGKVYIWS 195 Query: 236 IDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 I+ + KL H F+ D +++T SD V +W Sbjct: 196 IEKEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMW 237 Score = 30.0 bits (66), Expect = 1.3, Method: Compositional matrix adjust. Identities = 24/112 (21%), Positives = 50/112 (44%), Gaps = 12/112 (10%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQH-SDSQVNRLEITNDKKLLATAGHQNVRLYDIRTT 63 +++ G D + W LT ++TI + S V+ + + + A ++ + ++DI Sbjct: 225 VITGGSDRKVVMW--LTENGAKTISFTAPSPVHAVAACPTQAWICAATYEGIAVWDIGAK 282 Query: 64 NP----NPVASFEGHRG-----NVTSVSFQQDNRWMVTSSEDGTIKVWDVRS 106 P EG R + T +++ D + + DG+I+ W+V+S Sbjct: 283 QQIDLVQPNFKHEGKRNAGRTPDCTCLAWAADGSVLYSGYNDGSIRAWEVKS 334 >3ODT-A nrPDB Length = 313 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 65/282 (23%), Positives = 127/282 (45%), Gaps = 30/282 (10%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGH----QNVRLYDI 60 + S D T+R W + +N + ++K+LL G V L+ Sbjct: 32 VASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYDSEKELLLFGGKDTMINGVPLF-- 89 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPV 119 T+ +P+ + GH+GNV S+SFQ + +++ S D T KVW + S+ N + HNA V Sbjct: 90 ATSGEDPLYTLIGHQGNVCSLSFQ--DGVVISGSWDKTAKVW--KEGSLVYNLQAHNASV 145 Query: 120 -NEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAAN 178 + V+ ++ + ++ D I++W ++ + + ++ L++ DG ++ +N Sbjct: 146 WDAKVVSFSENKFLTASADKTIKLWQ--NDKVIKTFSGIHNDVVRHLAVVDDGHFISCSN 203 Query: 179 TKGNCYVWEMPNHTDASHLKPVTKFRAHSTYI--TRILLSSDVKHLATCSADHTARVWSI 236 + D + + H +++ ++L + D+ +C D T R+WS Sbjct: 204 DG-------LIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGDI---VSCGEDRTVRIWSK 253 Query: 237 DD-DFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 ++ K TL W DC + D ++ SSD+ VR++ Sbjct: 254 ENGSLKQVITLPAISIWSVDCMSNGD---IIVGSSDNLVRIF 292 Score = 40.4 bits (93), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 30/103 (29%), Positives = 50/103 (48%), Gaps = 6/103 (5%) Query: 200 VTKFRAH--STYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCA 257 V +AH S + +++ S+ K L T SAD T ++W D K+ T G V Sbjct: 135 VYNLQAHNASVWDAKVVSFSENKFL-TASADKTIKLWQND---KVIKTFSGIHNDVVRHL 190 Query: 258 FSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVAL 300 D + ++ S+D ++L D+ T +++R Y GH C+ L Sbjct: 191 AVVDDGHFISCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKL 233 >4LG8-A nrPDB Length = 354 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 59/232 (25%), Positives = 99/232 (42%), Gaps = 16/232 (6%) Query: 45 KLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDV 104 K+L +NV ++D ++ +A+ +GH VTSV F + ++S D TI++W V Sbjct: 86 KILTGGADKNVVVFD--KSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSV 143 Query: 105 RSPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTP-EDDTSL 162 + S + + H + V + +H L+S D + W + Q LT D+TS Sbjct: 144 PNASCVQVVRAHESAVTGLSLHATGDYLLSSSDD---QYWAFSDIQTGRVLTKVTDETSG 200 Query: 163 QSLSMAS---DGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDV 219 SL+ A DG + +W++ T+ V F HS IT I S + Sbjct: 201 CSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTN------VANFPGHSGPITSIAFSENG 254 Query: 220 KHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSD 271 +LAT + D + ++W + +T + V F YL +D Sbjct: 255 YYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD 306 Score = 68.2 bits (165), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 54/236 (22%), Positives = 100/236 (42%), Gaps = 12/236 (5%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEI--TNDKKLLATAGHQNVRLYDIR 61 ++ SA D TIR W C + ++ +S V L + T D LL+++ Q DI+ Sbjct: 128 LVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGD-YLLSSSDDQYWAFSDIQ 186 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVN 120 T + E ++T F D T + D IK+WD++ + N+ H+ P+ Sbjct: 187 TGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPIT 246 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 + N L + D ++++WDL + + L +++ ++SL G+ LA T Sbjct: 247 SIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD 306 Query: 181 GNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI 236 Y+ + + F HS T + K +A+ D + + +S+ Sbjct: 307 VQIYICK--------QWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 354 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 51/195 (26%), Positives = 81/195 (41%), Gaps = 7/195 (3%) Query: 86 DNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDGNIRIWD 144 D ++T D + V+D S I K H V VV HP+Q + S D IRIW Sbjct: 83 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 142 Query: 145 LGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFR 204 + C Q+ ++++ LS+ + G L +++ + W + L VT Sbjct: 143 VPNASCV-QVVRAHESAVTGLSLHATGDYLLSSS---DDQYWAFSDIQTGRVLTKVTD-E 197 Query: 205 AHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAY 264 +T D T + D ++W + + + GH + AFS + Y Sbjct: 198 TSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNV-ANFPGHSGPITSIAFSENGYY 256 Query: 265 LVTASSDHYVRLWDL 279 L TA+ D V+LWDL Sbjct: 257 LATAADDSSVKLWDL 271 Score = 31.6 bits (70), Expect = 0.40, Method: Compositional matrix adjust. Identities = 21/87 (24%), Positives = 35/87 (40%), Gaps = 1/87 (1%) Query: 214 LLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHY 273 L SD + T AD V+ + ++ TL GH + V F + +AS D Sbjct: 79 LCPSDTNKILTGGADKNVVVFDKSSE-QILATLKGHTKKVTSVVFHPSQDLVFSASPDAT 137 Query: 274 VRLWDLSTREIVRQYGGHHKGAVCVAL 300 +R+W + V+ H ++L Sbjct: 138 IRIWSVPNASCVQVVRAHESAVTGLSL 164 >6ID0-T nrPDB Length = 514 Score = 68.9 bits (167), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 56/232 (24%), Positives = 84/232 (36%), Gaps = 51/232 (21%) Query: 71 FEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQG 129 GH G V ++ + N+W VT S D TIK+WD+ S + + H + V V++ Sbjct: 200 ISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSP 259 Query: 130 ELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMP 189 L SC D ++ WDL N+ Sbjct: 260 YLFSCGEDKQVKCWDLEYNKV--------------------------------------- 280 Query: 190 NHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGH 249 + + H + + + L + L TCS D TAR+W + + TL GH Sbjct: 281 ----------IRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVH-TLSGH 329 Query: 250 QRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 V A ++T S D +RLWDL + H K V L+ Sbjct: 330 TNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLH 381 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 63/292 (21%), Positives = 123/292 (42%), Gaps = 25/292 (8%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGH-QNVRLYDIRTT 63 V+ D TI+ W+ +G ++ S V + ++ L + G + V+ +D+ Sbjct: 219 FVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYN 278 Query: 64 NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSP-SIPRNYKHNAPVNEV 122 + + GH V + +VT S D T ++WDVR+ S+ H V V Sbjct: 279 --KVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATV 336 Query: 123 VIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGN 182 + ++I+ D IR+WDL + LT S++++ + A+ + N Sbjct: 337 RCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLT-NHKKSVRAVVLHPRHYTFASG-SPDN 394 Query: 183 CYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKL 242 W+ P D S ++ H+ I + ++SD L + + + T +W + Sbjct: 395 IKQWKFP---DGSFIQ---NLSGHNAIINTLTVNSD-GVLVSGADNGTMHLWDWRTGYNF 447 Query: 243 ET--------TLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW---DLSTRE 283 + +LD + ++ CAF + L+TA +D ++++ D +T E Sbjct: 448 QRVHAAVQPGSLDS-ESGIFACAFDQSESRLLTAEADKTIKVYREDDTATEE 498 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 59/247 (23%), Positives = 100/247 (40%), Gaps = 9/247 (3%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQN-VRLYDI 60 S L S G D ++ W+ R S V L++ +L T + R++D+ Sbjct: 258 SPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDV 317 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPV 119 RT V + GH V +V Q ++T S D TI++WD+ + H V Sbjct: 318 RTKAS--VHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSV 375 Query: 120 NEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANT 179 VV+HP S D NI+ W + L+ + + +L++ SDG +++ A+ Sbjct: 376 RAVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQNLSGHNAI-INTLTVNSDGVLVSGADN 433 Query: 180 KGNCYVWEMPNHTDASHLKPVTKFRA--HSTYITRILLSSDVKHLATCSADHTARVWSID 237 G ++W+ + + + + + I L T AD T +V+ D Sbjct: 434 -GTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVYRED 492 Query: 238 DDFKLET 244 D ET Sbjct: 493 DTATEET 499 Score = 36.6 bits (83), Expect = 0.015, Method: Compositional matrix adjust. Identities = 16/52 (30%), Positives = 28/52 (53%) Query: 240 FKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGH 291 +KL + GH WV A + + VT S+D +++WDL++ ++ GH Sbjct: 194 WKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGH 245 >5Z56-q nrPDB Length = 504 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 59/232 (25%), Positives = 99/232 (42%), Gaps = 16/232 (6%) Query: 45 KLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDV 104 K+L +NV ++D ++ +A+ +GH VTSV F + ++S D TI++W V Sbjct: 236 KILTGGADKNVVVFD--KSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSV 293 Query: 105 RSPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTP-EDDTSL 162 + S + + H + V + +H L+S D + W + Q LT D+TS Sbjct: 294 PNASCVQVVRAHESAVTGLSLHATGDYLLSSSDD---QYWAFSDIQTGRVLTKVTDETSG 350 Query: 163 QSLSMAS---DGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDV 219 SL+ A DG + +W++ T+ V F HS IT I S + Sbjct: 351 CSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTN------VANFPGHSGPITSIAFSENG 404 Query: 220 KHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSD 271 +LAT + D + ++W + +T + V F YL +D Sbjct: 405 YYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD 456 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 54/235 (22%), Positives = 100/235 (42%), Gaps = 10/235 (4%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEI-TNDKKLLATAGHQNVRLYDIRT 62 ++ SA D TIR W C + ++ +S V L + LL+++ Q DI+T Sbjct: 278 LVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQT 337 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNE 121 + E ++T F D T + D IK+WD++ + N+ H+ P+ Sbjct: 338 GRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITS 397 Query: 122 VVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKG 181 + N L + D ++++WDL + + L +++ ++SL G+ LA T Sbjct: 398 IAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDV 457 Query: 182 NCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI 236 Y+ + T+ H F HS T + K +A+ D + + +S+ Sbjct: 458 QIYICK--QWTEILH------FTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 51/195 (26%), Positives = 81/195 (41%), Gaps = 7/195 (3%) Query: 86 DNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDGNIRIWD 144 D ++T D + V+D S I K H V VV HP+Q + S D IRIW Sbjct: 233 DTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWS 292 Query: 145 LGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFR 204 + C Q+ ++++ LS+ + G L +++ + W + L VT Sbjct: 293 VPNASCV-QVVRAHESAVTGLSLHATGDYLLSSS---DDQYWAFSDIQTGRVLTKVTD-E 347 Query: 205 AHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAY 264 +T D T + D ++W + + + GH + AFS + Y Sbjct: 348 TSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNV-ANFPGHSGPITSIAFSENGYY 406 Query: 265 LVTASSDHYVRLWDL 279 L TA+ D V+LWDL Sbjct: 407 LATAADDSSVKLWDL 421 Score = 33.1 bits (74), Expect = 0.15, Method: Compositional matrix adjust. Identities = 25/100 (25%), Positives = 40/100 (40%), Gaps = 5/100 (5%) Query: 206 HSTYITRILL----SSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSAD 261 HS I IL SD + T AD V+ + ++ TL GH + V F Sbjct: 217 HSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSE-QILATLKGHTKKVTSVVFHPS 275 Query: 262 SAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 + +AS D +R+W + V+ H ++L+ Sbjct: 276 QDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLH 315 >5OPT-p nrPDB Length = 318 Score = 67.4 bits (163), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 51/198 (25%), Positives = 89/198 (44%), Gaps = 15/198 (7%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTI---QHSD-SQVNRLEITNDKKLLATAGHQN-VRLYD 59 +VS G D+ +R W + G C T+ H+D R + + L+ + G N V+++D Sbjct: 124 IVSGGRDNALRVWN-VKGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWD 182 Query: 60 IRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPV 119 I + + +GH +TSV+ D +S +DG ++WD+ AP+ Sbjct: 183 I--ASGRLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPI 240 Query: 120 NEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPE------DDTSLQSLSMASDGSM 173 N++ PN+ + + G IRI+DL +L PE S++ ++DG+ Sbjct: 241 NQICFSPNRYWMCAATEKG-IRIFDLENKDVIVELAPEAQQKSKKTPECMSIAWSADGNT 299 Query: 174 LAAANTKGNCYVWEMPNH 191 L + T VW + H Sbjct: 300 LYSGYTDNVIRVWSVSEH 317 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 63/286 (22%), Positives = 120/286 (41%), Gaps = 64/286 (22%) Query: 6 VSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNP 65 VSA +DH++R W TGVC QH Sbjct: 83 VSASWDHSLRLWNLQTGVC----QHK---------------------------------- 104 Query: 66 NPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSP---SIPRNYKHNAPVNEV 122 F GH +V SV+F DNR +V+ D ++VW+V+ ++ R H V+ V Sbjct: 105 -----FLGHTKDVLSVTFSPDNRQIVSGGRDNALRVWNVKGECLHTLGRG-AHTDWVSCV 158 Query: 123 VIHPNQGE--LISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 P+ ++S D +++WD+ + L + + S++++ DGS+ A+++ Sbjct: 159 RFSPSLETPLIVSGGWDNLVKVWDIASGRLLTDLKGHTNY-ITSVTVSPDGSLCASSDKD 217 Query: 181 GNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDD-D 239 G +W++ S + A I +I S + ++ + + R++ +++ D Sbjct: 218 GVARLWDLTKGEALSEM-------AAGAPINQICFSPN-RYWMCAATEKGIRIFDLENKD 269 Query: 240 FKLETTLDGHQR-----WVWDCAFSADSAYLVTASSDHYVRLWDLS 280 +E + Q+ A+SAD L + +D+ +R+W +S Sbjct: 270 VIVELAPEAQQKSKKTPECMSIAWSADGNTLYSGYTDNVIRVWSVS 315 Score = 55.8 bits (133), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 57/249 (22%), Positives = 103/249 (41%), Gaps = 23/249 (9%) Query: 69 ASFEGHRGNVTSVSFQQDNRWM---VTSSEDGTIKVW----DVRSPSIPRNYK------H 115 +GHRG VT+++ Q V++S D T+ W D S + H Sbjct: 7 GQLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGH 66 Query: 116 NAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLA 175 +A V++V + N +S D ++R+W+L C H+ L S++ + D + Sbjct: 67 SAFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVL-SVTFSPDNRQIV 125 Query: 176 AANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSA--DHTARV 233 + VW + L + + AH+ +++ + S ++ S D+ +V Sbjct: 126 SGGRDNALRVWNVKGEC----LHTLGR-GAHTDWVSCVRFSPSLETPLIVSGGWDNLVKV 180 Query: 234 WSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQY-GGHH 292 W I +L T L GH ++ S D + ++ D RLWDL+ E + + G Sbjct: 181 WDIASG-RLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAP 239 Query: 293 KGAVCVALN 301 +C + N Sbjct: 240 INQICFSPN 248 >3DM0-A nrPDB Length = 694 Score = 67.4 bits (163), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 75/308 (24%), Positives = 138/308 (44%), Gaps = 43/308 (13%) Query: 4 ILVSAGYDHTIRFWEALT-----GVCSRTIQHSDSQVNRLEITNDKKL-LATAGHQNVRL 57 I+VSA D +I W+ GV R + V + +++D + L+ + +RL Sbjct: 397 IIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVLSSDGQFALSGSWDGELRL 456 Query: 58 YDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSP---SIPRNYK 114 +D+ F GH +V SV+F DNR +V++S D TIK+W+ +I + Sbjct: 457 WDLAAGVST--RRFVGHTKDVLSVAFSLDNRQIVSASRDRTIKLWNTLGECKYTISEGGE 514 Query: 115 -HNAPVNEVVIHPN--QGELISCDRDGNIRIWDLGENQCTHQLTPEDDTS-LQSLSMASD 170 H V+ V PN Q ++S D +++W+L + C + T T + +++++ D Sbjct: 515 GHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNL--SNCKLRSTLAGHTGYVSTVAVSPD 572 Query: 171 GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHT 230 GS+ A+ G +W D + K + A+S + L S ++ + +H Sbjct: 573 GSLCASGGKDGVVLLW------DLAEGKKLYSLEANS--VIHALCFSPNRYWLCAATEHG 624 Query: 231 ARVW-----SIDDDFKLETTLDGH----------QRWVWDCA---FSADSAYLVTASSDH 272 ++W SI +D K++ + +R V C +SAD + L + +D Sbjct: 625 IKIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKVIYCTSLNWSADGSTLFSGYTDG 684 Query: 273 YVRLWDLS 280 +R+W + Sbjct: 685 VIRVWGIG 692 Score = 57.8 bits (138), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 52/219 (23%), Positives = 100/219 (45%), Gaps = 14/219 (6%) Query: 73 GHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQGEL 131 GH V V D ++ ++ S DG +++WD+ + R + H V V + ++ Sbjct: 428 GHSHFVEDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQI 487 Query: 132 ISCDRDGNIRIWD-LGENQCTHQLTPE---DDTSLQSLSMASDGSMLAAANTKGNCYVWE 187 +S RD I++W+ LGE + T E D S S + + +A+ VW Sbjct: 488 VSASRDRTIKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWN 547 Query: 188 MPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLD 247 + S+ K + H+ Y++ + +S D A+ D +W + + KL +L+ Sbjct: 548 L------SNCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKL-YSLE 600 Query: 248 GHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVR 286 + + FS + Y + A+++H +++WDL ++ IV Sbjct: 601 ANSV-IHALCFSPNR-YWLCAATEHGIKIWDLESKSIVE 637 Score = 53.1 bits (126), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 54/221 (24%), Positives = 95/221 (42%), Gaps = 14/221 (6%) Query: 69 ASFEGHRGNVTSVSFQQDNR-WMVTSSEDGTIKVW----DVRSPSIP--RNYKHNAPVNE 121 + H VT+++ DN +V++S D +I +W D ++ + R H+ V + Sbjct: 376 GTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVED 435 Query: 122 VVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKG 181 VV+ + +S DG +R+WDL T + L S++ + D + +A+ Sbjct: 436 VVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVL-SVAFSLDNRQIVSASRDR 494 Query: 182 NCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSA--DHTARVWSIDDD 239 +W N H +++ + S + SA D T +VW++ + Sbjct: 495 TIKLW---NTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSN- 550 Query: 240 FKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLS 280 KL +TL GH +V A S D + + D V LWDL+ Sbjct: 551 CKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLA 591 Score = 51.2 bits (121), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 38/179 (21%), Positives = 82/179 (45%), Gaps = 14/179 (7%) Query: 131 LISCDRDGNIRIWDLGENQCTHQLTPEDDTS----LQSLSMASDGSMLAAANTKGNCYVW 186 ++S RD +I +W L ++ + + T ++ + ++SDG + + G +W Sbjct: 398 IVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVLSSDGQFALSGSWDGELRLW 457 Query: 187 EMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDD--FKLET 244 ++ +F H+ + + S D + + + S D T ++W+ + + + Sbjct: 458 DLAAGVS------TRRFVGHTKDVLSVAFSLDNRQIVSASRDRTIKLWNTLGECKYTISE 511 Query: 245 TLDGHQRWVWDCAFSADS--AYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 +GH+ WV FS ++ +V+AS D V++W+LS ++ GH VA++ Sbjct: 512 GGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCKLRSTLAGHTGYVSTVAVS 570 Score = 48.5 bits (114), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 31/104 (29%), Positives = 50/104 (48%), Gaps = 5/104 (4%) Query: 203 FRAHSTYITRILLSSD-VKHLATCSADHTARVWSIDDDFKL----ETTLDGHQRWVWDCA 257 RAH+ +T I D + + S D + +W + D K + L GH +V D Sbjct: 378 MRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVV 437 Query: 258 FSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 S+D + ++ S D +RLWDL+ R++ GH K + VA + Sbjct: 438 LSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFS 481 >4V7E-Bg nrPDB Length = 380 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 55/212 (25%), Positives = 98/212 (46%), Gaps = 14/212 (6%) Query: 43 DKKLLATAGHQNVRLYDIRTTNPNPVASFE---GHRGNVTSVSFQQDNRWM-VTSSEDGT 98 + +L+ +G Q L+D+ T + E GH +V S+S N M ++ S D T Sbjct: 170 ETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTT 229 Query: 99 IKVWDVR--SPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDL--GENQCTHQL 154 +++WD+R S ++ + H +N V P+ + DG R++D+ G + Sbjct: 230 VRLWDLRITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNR 289 Query: 155 TPE-DDTSL---QSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYI 210 P+ +D L S++ + G +L A + G+CYVW+ +L + +H I Sbjct: 290 EPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQN--SHEGRI 347 Query: 211 TRILLSSDVKHLATCSADHTARVWSIDDDFKL 242 + + LSSD L T S D ++W+ K+ Sbjct: 348 SCLGLSSDGSALCTGSWDKNLKIWAFSGHRKI 379 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 52/238 (21%), Positives = 96/238 (40%), Gaps = 30/238 (12%) Query: 70 SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAP-VNEVVIHPNQ 128 + +GH G V S+ + + W+V++S+DG + VW+ + K + P V E PN Sbjct: 61 TLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWVMECAFAPN- 119 Query: 129 GELISC----------------DRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGS 172 G+ ++C DRDGN+ + + LT + + + Sbjct: 120 GQSVACGGLDSACSIFNLSSQADRDGNMPV--------SRVLTGHKGYASSCQYVPDQET 171 Query: 173 MLAAANTKGNCYVWEMPNHTDASHLKPVTKF-RAHSTYITRILLSS-DVKHLATCSADHT 230 L + C +W++ S ++F H+ + + ++S + + S D T Sbjct: 172 RLITGSGDQTCVLWDVTTGQRISIFG--SEFPSGHTADVLSLSINSLNANMFISGSCDTT 229 Query: 231 ARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQY 288 R+W + + T GH+ + F D T S D RL+D+ T ++ Y Sbjct: 230 VRLWDLRITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVY 287 Score = 34.3 bits (77), Expect = 0.069, Method: Compositional matrix adjust. Identities = 34/195 (17%), Positives = 70/195 (35%), Gaps = 49/195 (25%) Query: 115 HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSML 174 H+ V + P + ++S +DG + +W+ +Q TH + ++ + A +G + Sbjct: 65 HSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCPWVME-CAFAPNGQSV 123 Query: 175 AAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVW 234 A C ++ + + D PV++ Sbjct: 124 ACGGLDSACSIFNLSSQADRDGNMPVSR-------------------------------- 151 Query: 235 SIDDDFKLETTLDGHQRWVWDCAFSAD-SAYLVTASSDHYVRLWDLSTREIVRQYG---- 289 L GH+ + C + D L+T S D LWD++T + + +G Sbjct: 152 ----------VLTGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFP 201 Query: 290 -GHHKGAVCVALNDV 303 GH + +++N + Sbjct: 202 SGHTADVLSLSINSL 216 >6QX9-4B nrPDB Length = 522 Score = 65.5 bits (158), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 58/238 (24%), Positives = 100/238 (42%), Gaps = 12/238 (5%) Query: 42 NDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKV 101 D L + A +V+L+ + + P VA EGH V V + R++ T+ D + ++ Sbjct: 292 KDVNLASCAADGSVKLWSLDSDEP--VADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRL 349 Query: 102 WDVRS-PSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDT 160 WD+ + I H+ V ++ H + + D R+WDL +C L Sbjct: 350 WDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLK- 408 Query: 161 SLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSS-DV 219 + ++ + +G +A + C VW D + V AH +T + Sbjct: 409 EIYGINFSPNGYHIATGSGDNTCKVW------DLRQRRCVYTIPAHQNLVTGVKFEPIHG 462 Query: 220 KHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 L T + D+TA++W+ L+ TL GH+ V S+D + T S D +LW Sbjct: 463 NFLLTGAYDNTAKIWTHPGWSPLK-TLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519 Score = 58.9 bits (141), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 50/240 (20%), Positives = 91/240 (37%), Gaps = 27/240 (11%) Query: 78 VTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQG------- 129 ++ F +++ + T+ G K+W V ++ + HN V +V HP Sbjct: 234 ISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKD 293 Query: 130 -ELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMA-----SDGSMLAAANTKGNC 183 L SC DG++++W L ++ P D ++ +A G L + Sbjct: 294 VNLASCAADGSVKLWSLDSDE------PVADIEGHTVRVARVMWHPSGRFLGTTCYDRSW 347 Query: 184 YVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLE 243 +W++ + H + HS + I D T D RVW + + Sbjct: 348 RLWDLEAQEEILHQE------GHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTG-RCI 400 Query: 244 TTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALNDV 303 L+GH + ++ FS + ++ T S D+ ++WDL R V H V + Sbjct: 401 MFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPI 460 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 42/152 (27%), Positives = 68/152 (44%), Gaps = 15/152 (9%) Query: 158 DDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILL-- 215 DD + + + MLA A G C +W +P+ + R H+T + I+ Sbjct: 230 DDRPISYCHFSPNSKMLATACWSGLCKLWSVPD------CNLLHTLRGHNTNVGAIVFHP 283 Query: 216 ----SSDVK--HLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTAS 269 S D K +LA+C+AD + ++WS+D D + ++GH V + +L T Sbjct: 284 KSTVSLDPKDVNLASCAADGSVKLWSLDSDEPV-ADIEGHTVRVARVMWHPSGRFLGTTC 342 Query: 270 SDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 D RLWDL +E + GH G +A + Sbjct: 343 YDRSWRLWDLEAQEEILHQEGHSMGVYDIAFH 374 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 47/192 (24%), Positives = 74/192 (38%), Gaps = 18/192 (9%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQ---VNRLEITNDKKLLATAGHQNV-RLYD 59 L + YD + R W+ I H + V + D L T G R++D Sbjct: 337 FLGTTCYDRSWRLWDL---EAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWD 393 Query: 60 IRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSP----SIPRNYKH 115 +RT + EGH + ++F + + T S D T KVWD+R +IP H Sbjct: 394 LRTGRC--IMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIP---AH 448 Query: 116 NAPVNEVVIHPNQGE-LISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSML 174 V V P G L++ D +IW L + + L ++SDG ++ Sbjct: 449 QNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEG-KVMGLDISSDGQLI 507 Query: 175 AAANTKGNCYVW 186 A + +W Sbjct: 508 ATCSYDRTFKLW 519 >5UZ7-B nrPDB Length = 351 Score = 64.7 bits (156), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 51/215 (23%), Positives = 91/215 (42%), Gaps = 14/215 (6%) Query: 25 SRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQ 84 SR + ++ +D +++ ++G L+DI T + H G+V S+S Sbjct: 147 SRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTG--HTGDVMSLSLA 204 Query: 85 QDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQGELISCDRDGNIRIW 143 D R V+ + D + K+WDVR + + H + +N + PN + D R++ Sbjct: 205 PDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLF 264 Query: 144 DLGENQCTHQLTPEDD---TSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPV 200 DL +Q +T D + S+S + G +L A NC VW DA Sbjct: 265 DLRADQ--ELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVW------DALKADRA 316 Query: 201 TKFRAHSTYITRILLSSDVKHLATCSADHTARVWS 235 H ++ + ++ D +AT S D ++W+ Sbjct: 317 GVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 351 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 66/286 (23%), Positives = 116/286 (40%), Gaps = 21/286 (7%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNV-RLYDI 60 S +LVSA D + W++ T I S V +A G N+ +Y++ Sbjct: 78 SRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNL 137 Query: 61 RTTNPNPVASFE--GHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNA 117 +T N S E GH G ++ F DN+ +VTSS D T +WD+ + + H Sbjct: 138 KTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHTG 196 Query: 118 PVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAA 177 V + + P+ +S D + ++WD+ E C T + + + ++ +G+ A Sbjct: 197 DVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHE-SDINAICFFPNGNAFATG 255 Query: 178 NTKGNCYVWEMPNHTDA---SHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVW 234 + C ++++ + SH + IT + S + L D VW Sbjct: 256 SDDATCRLFDLRADQELMTYSHDNIICG-------ITSVSFSKSGRLLLAGYDDFNCNVW 308 Query: 235 SIDDDFKLE--TTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWD 278 D K + L GH V + D + T S D ++++W+ Sbjct: 309 ---DALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 351 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 53/251 (21%), Positives = 101/251 (40%), Gaps = 28/251 (11%) Query: 62 TTNPNPVA--------SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY 113 T N +PV + GH + ++ + D+R +V++S+DG + +WD S N Sbjct: 45 TNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD----SYTTNK 100 Query: 114 KHNAPVNE----VVIHPNQGELISCDRDGNI-RIWDLGENQCTHQLTPE--DDTSLQSLS 166 H P+ + G ++C NI I++L + +++ E T S Sbjct: 101 VHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCC 160 Query: 167 MASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCS 226 D + + ++ C +W D + T F H+ + + L+ D + + + Sbjct: 161 RFLDDNQIVTSSGDTTCALW------DIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGA 214 Query: 227 ADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVR 286 D +A++W + + T GH+ + F + T S D RL+DL + + Sbjct: 215 CDASAKLWDVREGM-CRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELM 273 Query: 287 QYGGHHKGAVC 297 Y H +C Sbjct: 274 TY--SHDNIIC 282 >3JB9-g nrPDB Length = 558 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 59/246 (23%), Positives = 112/246 (45%), Gaps = 29/246 (11%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVN--RLEITNDK--KLLATAGHQNVRLYDI 60 +S +D TI+ W+ G C +SD N + ++ DK + LA + + +DI Sbjct: 325 FLSTSFDKTIKLWDTELGKCLNCF-NSDRLTNCVKFQVDPDKPNEFLAGTADKRILQFDI 383 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-----KH 115 R+ P+ V +++ H G + S++F ++ + VT+S+D +++ W+ +P +P + H Sbjct: 384 RS--PDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYGTP-VPIKFVADIAMH 440 Query: 116 NAPVNEVVIHPNQGELISCDR-DGNIRIWDLGENQCTHQLTPEDDTSLQSLSM----ASD 170 + P V + PN G+ I+C D I ++ E ++ S S+ + D Sbjct: 441 SMP--RVALRPN-GKSIACQSLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYSLEVGFSPD 497 Query: 171 GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILL-SSDVKHLATCS-AD 228 G + + ++ GN W D K + K AHS + + + +AT S D Sbjct: 498 GRFVFSGDSSGNACFW------DWKTCKLMAKLPAHSGPVQSMAFHPQETSKVATSSIVD 551 Query: 229 HTARVW 234 + + W Sbjct: 552 GSIKYW 557 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 61/294 (20%), Positives = 101/294 (34%), Gaps = 70/294 (23%) Query: 32 DSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMV 91 D+Q+ E+ +D+ LL T F+GH + +SF QD R + Sbjct: 288 DNQIKIWEVYHDRSLLRT---------------------FQGHARPIRDLSFSQDGRSFL 326 Query: 92 TSSEDGTIKVW--------------------------------------------DVRSP 107 ++S D TIK+W D+RSP Sbjct: 327 STSFDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGTADKRILQFDIRSP 386 Query: 108 SIPRNYKHN-APVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLS 166 I + Y H+ +N + N ++ D ++R W+ G + S+ ++ Sbjct: 387 DIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYGTPVPIKFVADIAMHSMPRVA 446 Query: 167 MASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCS 226 + +G +A + YV+ + K V K + S Y + S D + + + Sbjct: 447 LRPNGKSIACQSLDNCIYVYSAYEKYRQNK-KKVFKGYSCSGYSLEVGFSPDGRFVFSGD 505 Query: 227 ADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASS--DHYVRLWD 278 + A W KL L H V AF V SS D ++ WD Sbjct: 506 SSGNACFWDW-KTCKLMAKLPAHSGPVQSMAFHPQETSKVATSSIVDGSIKYWD 558 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 19/57 (33%), Positives = 30/57 (52%) Query: 222 LATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWD 278 L + S D+ ++W + D L T GH R + D +FS D ++ S D ++LWD Sbjct: 282 LLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQDGRSFLSTSFDKTIKLWD 338 >6GMH-W nrPDB Length = 305 Score = 63.9 bits (154), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 60/220 (27%), Positives = 92/220 (41%), Gaps = 11/220 (5%) Query: 84 QQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK---HNAPVNEVVIHPNQGELISCDRDGNI 140 ++++ +VT S D +KVW R + + H V V I S D +I Sbjct: 29 KENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHI 88 Query: 141 RIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPV 200 R+WDL EN + +L+ + D LA G ++ + + L Sbjct: 89 RLWDL-ENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTR 147 Query: 201 TKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSA 260 KF I I S D K+LA+ + D ++ I KL TL+GH + FS Sbjct: 148 GKF------ILSIAYSPDGKYLASGAIDGIINIFDIATG-KLLHTLEGHAMPIRSLTFSP 200 Query: 261 DSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVAL 300 DS LVTAS D Y++++D+ + GH + VA Sbjct: 201 DSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAF 240 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 63/249 (25%), Positives = 106/249 (42%), Gaps = 11/249 (4%) Query: 55 VRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK 114 V+++ R + S EGH+ V SV +SS D I++WD+ + ++ Sbjct: 44 VKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSID 103 Query: 115 HNAPVNE--VVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGS 172 PV+ + P+ L + G + I+ + + + L L S++ + DG Sbjct: 104 -AGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFIL-SIAYSPDGK 161 Query: 173 MLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTAR 232 LA+ G + N D + K + H+ I + S D + L T S D + Sbjct: 162 YLASGAIDG------IINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIK 215 Query: 233 VWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHH 292 ++ + L TL GH WV + AF D + V++SSD V++WD+ TR V + H Sbjct: 216 IYDVQHA-NLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQ 274 Query: 293 KGAVCVALN 301 V N Sbjct: 275 DQVWGVKYN 283 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 45/226 (19%), Positives = 98/226 (43%), Gaps = 11/226 (4%) Query: 54 NVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY 113 ++RL+D+ N + S + + +++F D++++ T + G + ++ V S + Sbjct: 87 HIRLWDLE--NGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSL 144 Query: 114 KHNAP-VNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGS 172 + + P+ L S DG I I+D+ + H L ++SL+ + D Sbjct: 145 DTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHA-MPIRSLTFSPDSQ 203 Query: 173 MLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTAR 232 +L A+ G ++ D H H++++ + D H + S+D + + Sbjct: 204 LLVTASDDGYIKIY------DVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVK 257 Query: 233 VWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWD 278 VW + + T D HQ VW ++ + + +V+ D + ++D Sbjct: 258 VWDVGTRTCVHTFFD-HQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302 Score = 50.8 bits (120), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 31/144 (21%), Positives = 65/144 (45%), Gaps = 4/144 (2%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGH-QNVRLYDIRT 62 I S+ D IR W+ G ++I L + D + LAT H V ++ + + Sbjct: 78 IAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVES 137 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNE 121 S + + S+++ D +++ + + DG I ++D+ + + + H P+ Sbjct: 138 GKKE--YSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRS 195 Query: 122 VVIHPNQGELISCDRDGNIRIWDL 145 + P+ L++ DG I+I+D+ Sbjct: 196 LTFSPDSQLLVTASDDGYIKIYDV 219 Score = 50.4 bits (119), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 37/149 (24%), Positives = 73/149 (48%), Gaps = 5/149 (3%) Query: 43 DKKLLATAGHQNV-RLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKV 101 D K LA+ + ++DI T + + EGH + S++F D++ +VT+S+DG IK+ Sbjct: 159 DGKYLASGAIDGIINIFDIATGKL--LHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKI 216 Query: 102 WDVRSPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDT 160 +DV+ ++ H + V V P+ +S D ++++WD+G C H D Sbjct: 217 YDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQD- 275 Query: 161 SLQSLSMASDGSMLAAANTKGNCYVWEMP 189 + + +GS + + ++++ P Sbjct: 276 QVWGVKYNGNGSKIVSVGDDQEIHIYDCP 304 Score = 42.0 bits (97), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 40/142 (28%), Positives = 69/142 (48%), Gaps = 4/142 (2%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQN-VRLYDIRTT 63 L S D I ++ TG T++ + L + D +LL TA +++YD++ Sbjct: 163 LASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQ-- 220 Query: 64 NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS-IPRNYKHNAPVNEV 122 + N + GH V +V+F D+ V+SS D ++KVWDV + + + + H V V Sbjct: 221 HANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGV 280 Query: 123 VIHPNQGELISCDRDGNIRIWD 144 + N +++S D I I+D Sbjct: 281 KYNGNGSKIVSVGDDQEIHIYD 302 >5WYK-BB nrPDB Length = 943 Score = 62.4 bits (150), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 59/282 (20%), Positives = 122/282 (43%), Gaps = 28/282 (9%) Query: 28 IQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDN 87 +Q + V ++I++D KLLATA + ++++++I+T + +FE G + F Sbjct: 387 LQGQRTDVRSIDISDDNKLLATASNGSLKIWNIKT--HKCIRTFEC--GYALTCKFLPGG 442 Query: 88 RWMVTSSEDGTIKVWDVRSPSIPRNYK--HNAPVNEVVIHPNQGELISCDRDGNIRIWDL 145 ++ + +G ++++D+ S S+ + H+A + + + + L++ D ++ WD Sbjct: 443 LLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDF 502 Query: 146 G---------ENQCTHQLTPEDDTSLQ------SLSMASDGSMLAAANTKGNCYVWEMPN 190 +N+ L DT+L+ + ++ D LA + V+ + + Sbjct: 503 KVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTVKVFFLDS 562 Query: 191 HTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQ 250 +K H + I +S D K + T SAD ++W +D +L HQ Sbjct: 563 ------MKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFG-DCHKSLFAHQ 615 Query: 251 RWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHH 292 + + F S + S D V+ WD E +++ H Sbjct: 616 DSIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQKLYAHQ 657 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 49/224 (21%), Positives = 96/224 (42%), Gaps = 23/224 (10%) Query: 32 DSQVNRLEITND-KKLLATAGHQNVRLYDIRTTN---PNPVASF----EGHRG------- 76 D+ + L++T+D K+L+ + + V+ +D + N P F + H Sbjct: 473 DAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTD 532 Query: 77 NVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRN-YKHNAPVNEVVIHPNQGELISCD 135 ++ V D+R++ S D T+KV+ + S + Y H PV + I + +I+ Sbjct: 533 DILCVRVSPDDRYLAISLLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISFDSKMIITSS 592 Query: 136 RDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDAS 195 D NI+IW L C L D+ + L ++ +C + + D Sbjct: 593 ADKNIKIWGLDFGDCHKSLFAHQDSIMNV-------KFLPQSHNFFSCSKDAVVKYWDGE 645 Query: 196 HLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDD 239 + + K AH + + + +++D + + S DH+ R+W +D Sbjct: 646 KFECIQKLYAHQSEVWALAVATDGGFVVSSSHDHSIRIWEETED 689 Score = 50.4 bits (119), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 45/202 (22%), Positives = 82/202 (40%), Gaps = 21/202 (10%) Query: 47 LATAGHQNVRLYDIRTTN---------PNPVASFEGHR-GNVTSVSFQQDNRWMVTSSED 96 L T+ ++V ++DI+T + P + G + T + +D + D Sbjct: 41 LITSALEDVNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLAVGYAD 100 Query: 97 GTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLT 155 G IKVWD+ S ++ N+ H A + + LIS +D NI +WDL ++L Sbjct: 101 GVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGEVGLYKLR 160 Query: 156 PEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILL 215 D+ D L + + G +W++ H + + AH+ + + Sbjct: 161 SHKDSITGFWCQGED--WLISTSKDGMIKLWDLKTH------QCIETHIAHTGECWGLAV 212 Query: 216 SSDVKHLATCSADHTARVWSID 237 D+ L T D ++W +D Sbjct: 213 KDDL--LITTGTDSQVKIWKLD 232 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 35/121 (28%), Positives = 59/121 (48%), Gaps = 7/121 (5%) Query: 33 SQVNRLEITNDKKLLATAGHQNV-RLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMV 91 ++ LE D LLA V +++D+ + + +F GH+ +T + F ++ Sbjct: 80 AECTYLEAHKDTDLLAVGYADGVIKVWDLMS--KTVLLNFNGHKAAITLLQFDGTGTRLI 137 Query: 92 TSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGE--LISCDRDGNIRIWDLGENQ 149 + S+D I VWD+ YK + + + QGE LIS +DG I++WDL +Q Sbjct: 138 SGSKDSNIIVWDLVGEV--GLYKLRSHKDSITGFWCQGEDWLISTSKDGMIKLWDLKTHQ 195 Query: 150 C 150 C Sbjct: 196 C 196 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 28/118 (23%), Positives = 61/118 (51%), Gaps = 4/118 (3%) Query: 35 VNRLEITNDKKLLATA-GHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTS 93 V ++I+ D K++ T+ +N++++ + + + S H+ ++ +V F + + Sbjct: 576 VLSIDISFDSKMIITSSADKNIKIWGLDFGDCHK--SLFAHQDSIMNVKFLPQSHNFFSC 633 Query: 94 SEDGTIKVWD-VRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQC 150 S+D +K WD + I + Y H + V + + + G ++S D +IRIW+ E+Q Sbjct: 634 SKDAVVKYWDGEKFECIQKLYAHQSEVWALAVATDGGFVVSSSHDHSIRIWEETEDQV 691 Score = 31.6 bits (70), Expect = 0.49, Method: Compositional matrix adjust. Identities = 25/91 (27%), Positives = 36/91 (39%), Gaps = 9/91 (9%) Query: 189 PNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDG 248 P +DA KP A TY+ D LA AD +VW + L +G Sbjct: 69 PGASDARGAKP-----AECTYLEA---HKDTDLLAVGYADGVIKVWDLMSKTVL-LNFNG 119 Query: 249 HQRWVWDCAFSADSAYLVTASSDHYVRLWDL 279 H+ + F L++ S D + +WDL Sbjct: 120 HKAAITLLQFDGTGTRLISGSKDSNIIVWDL 150 >5Y88-O nrPDB Length = 451 Score = 62.4 bits (150), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 49/176 (27%), Positives = 79/176 (44%), Gaps = 5/176 (2%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNV-RLYDIRTT 63 L S D T++ W+ R S V + I L+ATAG +V +L+D+RT Sbjct: 197 LFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLDLIATAGRDSVIKLWDMRTR 256 Query: 64 NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNA-PVNEV 122 P V + GH+G + V + +V+SS D T+++WDV + + H+ V Sbjct: 257 IP--VITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMKVLTHHKRSVRAT 314 Query: 123 VIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAAN 178 +HP + + S D +IR W L E E + +LS+ D + A + Sbjct: 315 ALHPKEFSVASACTD-DIRSWGLAEGSLLTNFESEKTGIINTLSINQDDVLFAGGD 369 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 53/226 (23%), Positives = 91/226 (40%), Gaps = 11/226 (4%) Query: 73 GHRGNVTSVSFQQ-DNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGE 130 GH G V V+ DN W +T S D T+KVWD+ + + H V +V + Sbjct: 137 GHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDVAVSDRHPY 196 Query: 131 LISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPN 190 L S D ++ WDL +NQ + ++++S+ ++A A +W+M Sbjct: 197 LFSVSEDKTVKCWDLEKNQIIRDYYGH-LSGVRTVSIHPTLDLIATAGRDSVIKLWDMRT 255 Query: 191 HTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQ 250 PV H I ++ + + + S D T R+W + K L H+ Sbjct: 256 RI------PVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAG-KTMKVLTHHK 308 Query: 251 RWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAV 296 R V A + +A +D +R W L+ ++ + G + Sbjct: 309 RSVRATALHPKEFSVASACTDD-IRSWGLAEGSLLTNFESEKTGII 353 Score = 54.7 bits (130), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 32/79 (40%), Positives = 41/79 (51%), Gaps = 1/79 (1%) Query: 222 LATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLST 281 T S D T +VW + KL+TTL GH V D A S YL + S D V+ WDL Sbjct: 155 FITGSNDTTMKVWDLATG-KLKTTLAGHVMTVRDVAVSDRHPYLFSVSEDKTVKCWDLEK 213 Query: 282 REIVRQYGGHHKGAVCVAL 300 +I+R Y GH G V++ Sbjct: 214 NQIIRDYYGHLSGVRTVSI 232 Score = 36.2 bits (82), Expect = 0.018, Method: Compositional matrix adjust. Identities = 20/64 (31%), Positives = 35/64 (54%), Gaps = 1/64 (1%) Query: 240 FKLETTLDGHQRWVWDCAF-SADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCV 298 +KL ++GH WV A D+ + +T S+D +++WDL+T ++ GH V Sbjct: 129 WKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDV 188 Query: 299 ALND 302 A++D Sbjct: 189 AVSD 192 Score = 29.6 bits (65), Expect = 1.5, Method: Compositional matrix adjust. Identities = 23/112 (20%), Positives = 54/112 (48%), Gaps = 4/112 (3%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITN-DKKLLATAGHQNVRLYDIRT 62 ++ +AG D I+ W+ T + T+ +N+++ T D ++++++ VRL+D+ Sbjct: 238 LIATAGRDSVIKLWDMRTRIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVA 297 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK 114 V + H+ +V + + + V S+ I+ W + S+ N++ Sbjct: 298 GKTMKVLTH--HKRSVRATALHP-KEFSVASACTDDIRSWGLAEGSLLTNFE 346 >3JAP-g nrPDB Length = 326 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 68/304 (22%), Positives = 133/304 (43%), Gaps = 38/304 (12%) Query: 4 ILVSAGYDHTIRFW-----EALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRL 57 +LVS D T+ W E GV R+ + V + ++ D +A + +RL Sbjct: 33 LLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDVVVSADGNYAVSASWDKTLRL 92 Query: 58 YDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNA 117 +++ T N A F GH G+V SV+ ++ ++++S D TI+VW+ H Sbjct: 93 WNLATGNSE--ARFVGHTGDVLSVAIDANSSKIISASRDKTIRVWNTVGDCAYVLLGHTD 150 Query: 118 PVNEVVIHPNQGE----------LISCDRDGNIRIWDLGENQCTHQLTPE---DDTSLQS 164 V +V + P E +S D +R W L E+ ++++ + + + Sbjct: 151 WVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWSLNED--SYRIEADFIGHNNYINV 208 Query: 165 LSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLAT 224 + + DGS+ A+A G YVW + + + + + A + +R L++ AT Sbjct: 209 VQPSPDGSLAASAGKDGQIYVWNLKHKSAFMNFDAKDEVFALAFSPSRFWLTA-----AT 263 Query: 225 CSADHTARVWSIDDDF---KLETTLDGHQRW----VWDCAFSADSAYLVTASSDHYVRLW 277 S +++ ++++ +L+ G+ + A+SAD L +D+ +R+W Sbjct: 264 ASG---IKIYDLENEVLIDELKPEFAGYTKAQDPHAVSLAWSADGQTLFAGYTDNVIRVW 320 Query: 278 DLST 281 + T Sbjct: 321 QVMT 324 Score = 39.7 bits (91), Expect = 0.001, Method: Compositional matrix adjust. Identities = 30/104 (28%), Positives = 51/104 (49%), Gaps = 5/104 (4%) Query: 203 FRAHSTYITRILLSSDVKHL-ATCSADHTARVWSIDDD---FKLET-TLDGHQRWVWDCA 257 H+ ++T + S+ +L + S D T W + ++ F + + GH V D Sbjct: 14 LEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDVV 73 Query: 258 FSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 SAD Y V+AS D +RLW+L+T ++ GH + VA++ Sbjct: 74 VSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAID 117 Score = 28.9 bits (63), Expect = 3.1, Method: Compositional matrix adjust. Identities = 21/56 (37%), Positives = 26/56 (46%), Gaps = 6/56 (10%) Query: 242 LETTLDGHQRWVWDCAFSADSA-YLVTASSDHYVRLWDLSTRE-----IVRQYGGH 291 L TL+GH WV + SA LV+ S D + W L+ E VR Y GH Sbjct: 10 LRGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGH 65 >5OQL-d nrPDB Length = 446 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 67/260 (25%), Positives = 116/260 (44%), Gaps = 24/260 (9%) Query: 35 VNRLEITNDKKLLATAGHQNVRLYD--IRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVT 92 V L TNDKKLL+ A ++L+D +N P+A+++ G TS+SF + Sbjct: 113 VKGLTFTNDKKLLSCAT-DGIKLWDPYASPSNTTPIATWQ-EGGPYTSLSFHRSANTFAA 170 Query: 93 SSEDGTIKVWDVRSPSIPRNYKHNAPVNEVV-IHPNQGE---LISCDRDGNIRIWDLGEN 148 SS G I++WD+ + + + + V+ + + NQ E + S D +I ++DL N Sbjct: 171 SSGQGCIRIWDLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTN 230 Query: 149 QCTHQLTPEDDTSL-----QSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKF 203 P T L + + + LA A+ N Y+++ N A +++ Sbjct: 231 M------PVIKTVLHFACNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQ----- 279 Query: 204 RAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSA 263 + H + + S + L + S D T R+W D + + V+ ++ DS Sbjct: 280 KGHVAAVMDVEFSPTGEELVSGSYDRTIRLWRRDAGHSRDVYHTKRMQRVFRTMWTMDSK 339 Query: 264 YLVTASSDHYVRLWDLSTRE 283 Y++T S D VRLW + E Sbjct: 340 YILTGSDDGNVRLWRANASE 359 >4U1E-I nrPDB Length = 347 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 48/232 (20%), Positives = 94/232 (40%), Gaps = 45/232 (19%) Query: 64 NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVV 123 N + + +GH G + S+ ++ VT S D +IK+WDV + +K PV V Sbjct: 41 NGERLGTLDGHTGTIWSIDVDCFTKYCVTGSADYSIKLWDVSNGQCVATWKSPVPVKRVE 100 Query: 124 IHPNQGELISC-----DRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSM--ASDGSMLAA 176 P ++ G+I I+++ + TH+LT + + + D + +A Sbjct: 101 FSPCGNYFLAILDNVMKNPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAG 160 Query: 177 ANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI 236 +TKG K++ D + + Sbjct: 161 WSTKG--------------------------------------KYIIAGHKDGKISKYDV 182 Query: 237 DDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQY 288 ++++ ++D H++ + D FS D Y +T+S D L D+ST +++++Y Sbjct: 183 SNNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLVDVSTLQVLKKY 234 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 27/84 (32%), Positives = 44/84 (52%), Gaps = 1/84 (1%) Query: 202 KFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSAD 261 K H +T++ + + L +CS D +A VW + +L TLDGH +W Sbjct: 5 KLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERL-GTLDGHTGTIWSIDVDCF 63 Query: 262 SAYLVTASSDHYVRLWDLSTREIV 285 + Y VT S+D+ ++LWD+S + V Sbjct: 64 TKYCVTGSADYSIKLWDVSNGQCV 87 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 23/79 (29%), Positives = 43/79 (54%), Gaps = 3/79 (3%) Query: 50 AGHQNVRL--YDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSP 107 AGH++ ++ YD+ + N V S + H +++ + F D + +TSS D + DV + Sbjct: 170 AGHKDGKISKYDV-SNNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLVDVSTL 228 Query: 108 SIPRNYKHNAPVNEVVIHP 126 + + Y+ + P+N VI P Sbjct: 229 QVLKKYETDCPLNTAVITP 247 >5NZU-C nrPDB Length = 905 Score = 61.2 bits (147), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 46/227 (20%), Positives = 98/227 (43%), Gaps = 11/227 (4%) Query: 78 VTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKH-NAPVNEVVIHPNQGELISCDR 136 V SV WM+ S +G++ VW+ + ++ + ++ + PV + +++ Sbjct: 18 VKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGAD 77 Query: 137 DGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASH 196 D IR+++ + H D ++ +++ + ++ +W+ S Sbjct: 78 DMQIRVFNYNTLERVHMFEAHSDY-IRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQ 136 Query: 197 LKPVTKFRAHSTYITRILLS-SDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWV-- 253 + F H+ Y+ +I+++ D A+ S D T +VW + TL+GH++ V Sbjct: 137 V-----FEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSS-SPNFTLEGHEKGVNC 190 Query: 254 WDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVAL 300 D D YL++ + D V++WD + V+ GH + C + Sbjct: 191 IDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASF 237 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 54/238 (22%), Positives = 101/238 (42%), Gaps = 15/238 (6%) Query: 68 VASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHP 126 V +FE V + F W+VT ++D I+V++ + ++ H+ + + +HP Sbjct: 50 VKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHP 109 Query: 127 NQGELISCDRDGNIRIWDLGEN-QCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYV 185 Q +++ D I++WD + C+ +Q + D + A+A+ V Sbjct: 110 TQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKV 169 Query: 186 WEM----PNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFK 241 W++ PN T H K V +S D +L + + D ++W + Sbjct: 170 WQLGSSSPNFTLEGHEKGVNCIDYYS--------GGDKPYLISGADDRLVKIWDYQNKTC 221 Query: 242 LETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVA 299 ++T L+GH + V +F + ++T S D VR+W ST + + CVA Sbjct: 222 VQT-LEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVA 278 Score = 48.9 bits (115), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 31/101 (30%), Positives = 56/101 (55%), Gaps = 5/101 (4%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITN--DKK-LLATAGHQNVRLYDIR 61 SA D TI+ W+ + + T++ + VN ++ + DK L++ A + V+++D + Sbjct: 158 FASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQ 217 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW 102 N V + EGH NV+ SF + ++T SEDGT+++W Sbjct: 218 --NKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIW 256 >4V6W-Ag nrPDB Length = 318 Score = 60.5 bits (145), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 55/246 (22%), Positives = 109/246 (44%), Gaps = 23/246 (9%) Query: 47 LATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRS 106 L+ + Q +RL+D+ FEGH +V SV+F DNR +V+ S D TIK+W+ + Sbjct: 80 LSGSWDQTLRLWDLAAGKT--TRRFEGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTLA 137 Query: 107 PS--IPRNYKHNAPVNEVVIHPNQGE--LISCDRDGNIRIWDLGENQCTHQLTPEDDTSL 162 + H V+ V PN ++SC D +++W+L + + + L Sbjct: 138 ECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCKLKNNHHGHNGY-L 196 Query: 163 QSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHL 222 +++++ DGS+ + +W++ + + L+ H+ I + S + ++ Sbjct: 197 NTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLE-------HNDIINALCFSPN-RYW 248 Query: 223 ATCSADHTARVWSID-----DDFKLET---TLDGHQRWVWDCAFSADSAYLVTASSDHYV 274 + + ++W + ++ + E T Q A+S D L SD+ + Sbjct: 249 LCVAYGPSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTLFAGYSDNTI 308 Query: 275 RLWDLS 280 R+W +S Sbjct: 309 RVWQVS 314 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 38/130 (29%), Positives = 64/130 (49%), Gaps = 2/130 (1%) Query: 170 DGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADH 229 D + +A+ VW++ D ++ P + HS +I+ ++LSSD + + S D Sbjct: 27 DPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDVVLSSDGNYALSGSWDQ 86 Query: 230 TARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWD-LSTREIVRQY 288 T R+W + K +GH + V AFSAD+ +V+ S D ++LW+ L+ + Q Sbjct: 87 TLRLWDLAAG-KTTRRFEGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTLAECKFTIQE 145 Query: 289 GGHHKGAVCV 298 GH CV Sbjct: 146 DGHTDWVSCV 155 Score = 57.4 bits (137), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 41/186 (22%), Positives = 85/186 (45%), Gaps = 14/186 (7%) Query: 115 HNAPVNEVVIHPNQGE-LISCDRDGNIRIWDLGENQCTHQLTPEDDTS-----LQSLSMA 168 HN V ++ +P + +IS RD + +W L ++ T+ P+ + + ++ Sbjct: 14 HNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDVVLS 73 Query: 169 SDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSAD 228 SDG+ + + +W D + K +F H+ + + S+D + + + S D Sbjct: 74 SDGNYALSGSWDQTLRLW------DLAAGKTTRRFEGHTKDVLSVAFSADNRQIVSGSRD 127 Query: 229 HTARVWSIDDDFKLETTLDGHQRWVWDCAFSAD--SAYLVTASSDHYVRLWDLSTREIVR 286 T ++W+ + K DGH WV FS + + +V+ D V++W+L+ ++ Sbjct: 128 KTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCKLKN 187 Query: 287 QYGGHH 292 + GH+ Sbjct: 188 NHHGHN 193 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 31/103 (30%), Positives = 53/103 (51%), Gaps = 6/103 (5%) Query: 205 AHSTYITRILLS-SDVKHLATCSADHTARVWSI--DDDFKL---ETTLDGHQRWVWDCAF 258 H+ ++T+I + D + + S D T VW + D+D + L GH ++ D Sbjct: 13 GHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDVVL 72 Query: 259 SADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 S+D Y ++ S D +RLWDL+ + R++ GH K + VA + Sbjct: 73 SSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFS 115 Score = 43.9 bits (102), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 43/194 (22%), Positives = 70/194 (36%), Gaps = 54/194 (27%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTT 63 I+VS G+D T++ W LA +N Sbjct: 165 IIVSCGWDRTVKVWN----------------------------LANCKLKN--------- 187 Query: 64 NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVV 123 + GH G + +V+ D + +D +WD+ +HN +N + Sbjct: 188 ------NHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLEHNDIINALC 241 Query: 124 IHPNQGELISCDRDG-NIRIWDLGENQCTHQLTPE--------DDTSLQSLSMASDGSML 174 PN+ L C G +I+IWDL + +L PE D SL+ ++DG L Sbjct: 242 FSPNRYWL--CVAYGPSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTL 299 Query: 175 AAANTKGNCYVWEM 188 A + VW++ Sbjct: 300 FAGYSDNTIRVWQV 313 >6BX3-A nrPDB Length = 314 Score = 59.7 bits (143), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 50/208 (24%), Positives = 97/208 (46%), Gaps = 30/208 (14%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQ-HSDSQVNRLEITNDKKLLATAGHQN-VRLYDIR 61 +L ++ D +I+ W+ L G +TI HS++ V+ ND +L++ + +R++D Sbjct: 109 LLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAE 168 Query: 62 TTNPNPVASFEG--HRGN----VTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKH 115 T + +++ R N ++ V F ++ R+++ S DG +K+WD + R ++ Sbjct: 169 TGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQV 228 Query: 116 NAPVNEVVIH---------PNQGE---LISCDRDGNIRIWDLGENQCTHQLTPEDDTSL- 162 P+ + V+H P G +IS +G+I W N T L D SL Sbjct: 229 Q-PLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCW----NSDTKSLLQLLDGSLY 283 Query: 163 ----QSLSMASDGSMLAAANTKGNCYVW 186 +S+ G+++ + G+C +W Sbjct: 284 HHSSPVMSIHCFGNIMCSLALNGDCCLW 311 Score = 47.8 bits (112), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 30/92 (32%), Positives = 46/92 (50%), Gaps = 2/92 (2%) Query: 70 SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQ 128 +F GH V S++F + + TSS D +IK+WD + S+ + H+ V V + N Sbjct: 90 TFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMND 149 Query: 129 GELISCDR-DGNIRIWDLGENQCTHQLTPEDD 159 ++S DG IRI+D C LT + D Sbjct: 150 SSILSSGSYDGLIRIFDAETGHCLKTLTYDKD 181 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 49/252 (19%), Positives = 95/252 (37%), Gaps = 46/252 (18%) Query: 39 EITNDKKLLATAGHQNVRLYDI--RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSED 96 +I+ D + LA N+ +YDI RT + V S H + + + D + + T+S+D Sbjct: 19 KISPDGQFLAITQGLNILIYDINRRTVSQTLVTS---HARPFSELCWSPDGQCIATASDD 75 Query: 97 GTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTP 156 ++++ + + H APV + + L + D +I+IWD ++ Sbjct: 76 FSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISA 135 Query: 157 EDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLS 216 + + +D S+L++ + G + RI Sbjct: 136 HSEAVVSVDVPMNDSSILSSGSYDG----------------------------LIRIF-- 165 Query: 217 SDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRL 276 H + + D D+K E + + FS ++ YL+ S D V++ Sbjct: 166 -------DAETGHCLKTLTYDKDWKRENGVVP----ISQVKFSENARYLLVKSLDGVVKI 214 Query: 277 WDLSTREIVRQY 288 WD +VR + Sbjct: 215 WDCIGGCVVRTF 226 Score = 35.8 bits (81), Expect = 0.022, Method: Compositional matrix adjust. Identities = 34/139 (24%), Positives = 61/139 (43%), Gaps = 12/139 (8%) Query: 167 MASDGSMLAAANTKG-NCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATC 225 ++ DG LA T+G N ++++ T + T +H+ + + S D + +AT Sbjct: 20 ISPDGQFLAI--TQGLNILIYDINRRTVSQ-----TLVTSHARPFSELCWSPDGQCIATA 72 Query: 226 SADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIV 285 S D + + I + L T GH V F+ L T+S D +++WD ++ Sbjct: 73 SDDFSVEI--IHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLM 130 Query: 286 RQYGGHHKGAVC--VALND 302 + H + V V +ND Sbjct: 131 KTISAHSEAVVSVDVPMND 149 >3FM0-A nrPDB Length = 345 Score = 58.5 bits (140), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 48/187 (25%), Positives = 85/187 (45%), Gaps = 16/187 (8%) Query: 115 HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGEN--QCTHQLTPEDDTSLQSLSMASDGS 172 H V +V P L S D IW ++ +C L ++ ++S++ A G+ Sbjct: 60 HQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHEN-EVKSVAWAPSGN 118 Query: 173 MLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTAR 232 +LA + + +VWE+ + + V+ +H+ + ++ + LA+ S D T + Sbjct: 119 LLATCSRDKSVWVWEV---DEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVK 175 Query: 233 VW-SIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQY-GG 290 ++ +DD+ TL+GH+ VW AF L + S D VR+W RQY G Sbjct: 176 LYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW--------RQYLPG 227 Query: 291 HHKGAVC 297 + +G C Sbjct: 228 NEQGVAC 234 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 60/253 (23%), Positives = 98/253 (38%), Gaps = 19/253 (7%) Query: 4 ILVSAGYDHTIRFW--EALTGVCSRTIQHSDSQ-VNRLEITNDKKLLATAGHQNVR-LYD 59 +L S G D IR W E + +C + + V ++ + LA+A ++ Sbjct: 30 LLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWK 89 Query: 60 IRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDV----RSPSIPRNYKH 115 + V + EGH V SV++ + T S D ++ VW+V + H Sbjct: 90 KNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSH 149 Query: 116 NAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPED-DTSLQSLSMASDGSML 174 V VV HP+Q L S D ++++ E+ T E ++++ SL+ G L Sbjct: 150 TQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRL 209 Query: 175 AAANTKGNCYVWE--MPNH--------TDASHLKPVTKFRAHSTYITRILLSSDVKHLAT 224 A+ + +W +P + +D S T HS I I LAT Sbjct: 210 ASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALAT 269 Query: 225 CSADHTARVWSID 237 D RV+ D Sbjct: 270 ACGDDAIRVFQED 282 >6J6H-n nrPDB Length = 455 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 49/237 (20%), Positives = 102/237 (43%), Gaps = 19/237 (8%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLE--ITNDKKLLATAGHQNVRLYDIRT 62 +S+ +D +++ W+ TG +T H +S +E TN + + + + YD R Sbjct: 221 FLSSSFDRSVKIWDTETGKV-KTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRV 279 Query: 63 T-NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWD----VRSPSIPRNYKHNA 117 + N V +++ H ++ ++ + D ++SSED T+++W+ V I +H+ Sbjct: 280 SENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSM 339 Query: 118 PVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQ----SLSMASDGSM 173 P + +HP+Q + D I + L H S SL+ + DG Sbjct: 340 PF--LNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRY 397 Query: 174 LAAANTKGNCYVWE-----MPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATC 225 + + ++K + W+ + N+ KP+T+ H ++++ S + C Sbjct: 398 ICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVC 454 Score = 50.4 bits (119), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 50/222 (22%), Positives = 94/222 (42%), Gaps = 12/222 (5%) Query: 71 FEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHP-NQG 129 F+GH + ++ F +D + ++SS D ++K+WD + + N+ +V P N Sbjct: 202 FQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPH 261 Query: 130 ELISCDRDGNIRIWD--LGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWE 187 E I + I +D + ENQ Q +S+ +L DGS +++ +WE Sbjct: 262 EFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321 Query: 188 MPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKL--ETT 245 N + +K ++ HS + S + + S D+ +S+ +K + Sbjct: 322 --NQINVP-IKQISDTAQHSMPFLNVHPSQN--YFCAQSMDNRIYSFSLKPKYKRHPKKI 376 Query: 246 LDGHQR--WVWDCAFSADSAYLVTASSDHYVRLWDLSTREIV 285 GH + AFS D Y+ + S + WD +T ++ Sbjct: 377 FKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLL 418 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 20/88 (22%), Positives = 37/88 (42%), Gaps = 1/88 (1%) Query: 198 KPVTKFRAHSTYITRILLSSDVKHLATCSA-DHTARVWSIDDDFKLETTLDGHQRWVWDC 256 K + + H T + HL DHT ++W D++ GH + + Sbjct: 153 KVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKAL 212 Query: 257 AFSADSAYLVTASSDHYVRLWDLSTREI 284 F+ D +++S D V++WD T ++ Sbjct: 213 RFTEDCQSFLSSSFDRSVKIWDTETGKV 240 >6QDV-o nrPDB Length = 513 Score = 55.8 bits (133), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 58/247 (23%), Positives = 107/247 (43%), Gaps = 32/247 (12%) Query: 5 LVSAGYDHTIRFWEALTGVC-SRTIQHSDSQVNRLEITNDKKLLATAGHQNVRL--YDIR 61 +SA YD ++ W+ TG C SR + DK+ L AG + ++ +DIR Sbjct: 281 FLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIR 340 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAP--- 118 + V ++ H G V ++ F +NR V++S+D +++VW+ IP ++K+ A Sbjct: 341 SGEI--VQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEW---DIPVDFKYIAEPSM 395 Query: 119 --VNEVVIHPNQGELISCD-RDGNIRIWDLGENQCTHQLTPEDDTSLQSLS-------MA 168 + V + PN G+ ++C D I I+ Q +L + ++ + Sbjct: 396 HSMPAVTLSPN-GKWLACQSMDNQILIFGA---QNRFRLNKKKIFKGHMVAGYACQVDFS 451 Query: 169 SDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTY-ITRILLSSDVKHLATCSA 227 D S + + + G +W D K ++F+AH I + + + TC Sbjct: 452 PDMSYVISGDGNGKLNIW------DWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGW 505 Query: 228 DHTARVW 234 D ++W Sbjct: 506 DGLIKLW 512 Score = 54.7 bits (130), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 68/306 (22%), Positives = 117/306 (38%), Gaps = 63/306 (20%) Query: 4 ILVSAGYDHTIRFWEAL-TGVCSRT-IQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIR 61 +L+S D I+ WE C RT I HS + + T + L+ A + ++L+D Sbjct: 237 LLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTE 296 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQD---NRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNA 117 T ++ F +R V F D V D I WD+RS I + Y +H Sbjct: 297 TGQC--ISRFT-NRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLG 353 Query: 118 PVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAA 177 VN +V +S D ++R+W+ Sbjct: 354 AVNTIVFVDENRRFVSTSDDKSLRVWE--------------------------------- 380 Query: 178 NTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSID 237 W++P K + + HS + + LS + K LA S D+ ++ Sbjct: 381 --------WDIP-----VDFKYIAEPSMHS--MPAVTLSPNGKWLACQSMDNQILIFGAQ 425 Query: 238 DDFKL--ETTLDGHQRWVWDCA--FSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHK 293 + F+L + GH + C FS D +Y+++ + + +WD T ++ ++ H K Sbjct: 426 NRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDK 485 Query: 294 GAVCVA 299 VC+ Sbjct: 486 --VCIG 489 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 32/131 (24%), Positives = 55/131 (41%), Gaps = 10/131 (7%) Query: 171 GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHT 230 G L + CY+ + H + H K V+ R L L +CS D Sbjct: 196 GVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVR---------LFPLSGHLLLSCSMDCK 246 Query: 231 ARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGG 290 ++W + + + T GH + V D F+ ++A+ D Y++LWD T + + ++ Sbjct: 247 IKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRF-T 305 Query: 291 HHKGAVCVALN 301 + K CV N Sbjct: 306 NRKVPYCVKFN 316 Score = 41.2 bits (95), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 27/106 (25%), Positives = 49/106 (46%), Gaps = 12/106 (11%) Query: 43 DKKLLATAGHQNVRLYDIRTTNPNPVASFEGHR--GNVTSVSFQQDNRWMVTSSEDGTIK 100 D ++L RL N F+GH G V F D ++++ +G + Sbjct: 416 DNQILIFGAQNRFRL--------NKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLN 467 Query: 101 VWDVRSPSIPRNYK-HNAPVNEVVIHPNQ-GELISCDRDGNIRIWD 144 +WD ++ + +K H+ V HP++ ++I+C DG I++WD Sbjct: 468 IWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 513 >5YZG-W nrPDB Length = 579 Score = 55.1 bits (131), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 58/247 (23%), Positives = 107/247 (43%), Gaps = 32/247 (12%) Query: 5 LVSAGYDHTIRFWEALTGVC-SRTIQHSDSQVNRLEITNDKKLLATAGHQNVRL--YDIR 61 +SA YD ++ W+ TG C SR + DK+ L AG + ++ +DIR Sbjct: 347 FLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIR 406 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAP--- 118 + V ++ H G V ++ F +NR V++S+D +++VW+ IP ++K+ A Sbjct: 407 SGEI--VQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEW---DIPVDFKYIAEPSM 461 Query: 119 --VNEVVIHPNQGELISCD-RDGNIRIWDLGENQCTHQLTPEDDTSLQSLS-------MA 168 + V + PN G+ ++C D I I+ Q +L + ++ + Sbjct: 462 HSMPAVTLSPN-GKWLACQSMDNQILIFGA---QNRFRLNKKKIFKGHMVAGYACQVDFS 517 Query: 169 SDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTY-ITRILLSSDVKHLATCSA 227 D S + + + G +W D K ++F+AH I + + + TC Sbjct: 518 PDMSYVISGDGNGKLNIW------DWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGW 571 Query: 228 DHTARVW 234 D ++W Sbjct: 572 DGLIKLW 578 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 68/306 (22%), Positives = 115/306 (37%), Gaps = 63/306 (20%) Query: 4 ILVSAGYDHTIRFWEAL-TGVCSRT-IQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIR 61 +L+S D I+ WE C RT I HS + + T + L+ A + ++L+D Sbjct: 303 LLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTE 362 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQD---NRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNA 117 T S +R V F D V D I WD+RS I + Y +H Sbjct: 363 TGQ---CISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLG 419 Query: 118 PVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAA 177 VN +V +S D ++R+W+ Sbjct: 420 AVNTIVFVDENRRFVSTSDDKSLRVWE--------------------------------- 446 Query: 178 NTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSID 237 W++P K + + HS + + LS + K LA S D+ ++ Sbjct: 447 --------WDIP-----VDFKYIAEPSMHS--MPAVTLSPNGKWLACQSMDNQILIFGAQ 491 Query: 238 DDFKL--ETTLDGHQRWVWDCA--FSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHK 293 + F+L + GH + C FS D +Y+++ + + +WD T ++ ++ H K Sbjct: 492 NRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDK 551 Query: 294 GAVCVA 299 VC+ Sbjct: 552 --VCIG 555 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 32/131 (24%), Positives = 55/131 (41%), Gaps = 10/131 (7%) Query: 171 GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHT 230 G L + CY+ + H + H K V+ R L L +CS D Sbjct: 262 GVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVR---------LFPLSGHLLLSCSMDCK 312 Query: 231 ARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGG 290 ++W + + + T GH + V D F+ ++A+ D Y++LWD T + + ++ Sbjct: 313 IKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRF-T 371 Query: 291 HHKGAVCVALN 301 + K CV N Sbjct: 372 NRKVPYCVKFN 382 Score = 41.2 bits (95), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 36/147 (24%), Positives = 69/147 (46%), Gaps = 7/147 (4%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTI-QHSDSQVNRLEITNDKKLLATAGHQN-VRLYDIRT 62 VS D ++R WE V + I + S + + ++ + K LA N + ++ + Sbjct: 433 FVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQN 492 Query: 63 T-NPNPVASFEGHR--GNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAP 118 N F+GH G V F D ++++ +G + +WD ++ + +K H+ Sbjct: 493 RFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKV 552 Query: 119 VNEVVIHPNQ-GELISCDRDGNIRIWD 144 V HP++ ++I+C DG I++WD Sbjct: 553 CIGAVWHPHETSKVITCGWDGLIKLWD 579 >5OQL-L nrPDB Length = 557 Score = 55.1 bits (131), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 35/117 (29%), Positives = 61/117 (52%), Gaps = 4/117 (3%) Query: 4 ILVSAGYDHTIRFWEA-LTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRT 62 +LVS YD T+R W+A G T +H+D + L + + LLA +G+ + + D+ Sbjct: 204 LLVSGSYDETVRVWDARAPGGAVMTFKHADPIEDVLPLPSGTTLLAASGNA-ISVLDLVA 262 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPV 119 P + H+ VTS+S R +V+ S DG +KV++ S ++ K+ +P+ Sbjct: 263 AKP--LRLITNHQKTVTSLSLASQGRRVVSGSLDGHVKVFETTSWNVVAGAKYPSPI 317 Score = 43.1 bits (100), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 61/256 (23%), Positives = 105/256 (41%), Gaps = 27/256 (10%) Query: 41 TNDKKLLATAGHQNVRLYDIRTTNP-NPVASF--EGHRGNVTSVSFQQDNRWMVTSSEDG 97 TND L A V ++ IR P + F E H G + + D R +V + G Sbjct: 69 TND--LFAVTAGPRVEIFSIRKREPLKTIGRFDSEAHCGEI-----RPDGRVLVAGEDTG 121 Query: 98 TIKVWDV----RSPSIPRNYKHNAPVNEVVIHPNQ-GELISCDRDGNIRIWDLGENQCTH 152 ++V+DV R+ + + H PV P + L+SC D +R+WDL N T Sbjct: 122 RMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPTR 181 Query: 153 QLTPEDDTSLQSLSM--ASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYI 210 T D M +++ ++L + + VW+ A V F+ H+ I Sbjct: 182 LFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGA-----VMTFK-HADPI 235 Query: 211 TRIL-LSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTAS 269 +L L S LA + +L T HQ+ V + ++ +V+ S Sbjct: 236 EDVLPLPSGTTLLAASGNAISVLDLVAAKPLRLITN---HQKTVTSLSLASQGRRVVSGS 292 Query: 270 SDHYVRLWDLSTREIV 285 D +V++++ ++ +V Sbjct: 293 LDGHVKVFETTSWNVV 308 Score = 32.0 bits (71), Expect = 0.38, Method: Compositional matrix adjust. Identities = 18/53 (33%), Positives = 27/53 (50%), Gaps = 1/53 (1%) Query: 249 HQRWVWDCAFSA-DSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVAL 300 H++ VW +S + L++ S D VRLWDL + + R + GH C A Sbjct: 143 HKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPTRLFTGHTDYVRCGAF 195 >5L9T-R nrPDB Length = 493 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 59/241 (24%), Positives = 102/241 (42%), Gaps = 20/241 (8%) Query: 5 LVSAG-YDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTT 63 LV+ G + ++ W+A G ++ ++V L N ++L + + + + DIRT Sbjct: 243 LVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAW-NAEQLSSGSRDRMILQRDIRTP 301 Query: 64 NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEV 122 +GHR V + + D++ + + D + VW+ S S + Y +H A V + Sbjct: 302 PLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAI 361 Query: 123 VIHPNQGELISCD---RDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANT 179 P+Q L++ D IR W N T Q DT Q ++A +T Sbjct: 362 AWSPHQHGLLASGGGTADRCIRFW----NTLTGQPLQCIDTGSQVCNLAWSKHANELVST 417 Query: 180 KG----NCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWS 235 G VW+ P+ T V K HS + + +S D + + T + D T R W+ Sbjct: 418 HGYSQNQILVWKYPSLTQ------VAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWN 471 Query: 236 I 236 + Sbjct: 472 V 472 Score = 40.8 bits (94), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 29/105 (27%), Positives = 47/105 (44%), Gaps = 2/105 (1%) Query: 4 ILVSAG--YDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIR 61 +L S G D IRFW LTG + I N + +L++T G+ ++ + Sbjct: 370 LLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWK 429 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRS 106 + VA GH V ++ D +VT + D T++ W+V S Sbjct: 430 YPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFS 474 Score = 40.4 bits (93), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 38/156 (24%), Positives = 69/156 (44%), Gaps = 14/156 (8%) Query: 150 CTHQLTPEDDTSLQSLSMAS-----DGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFR 204 CT Q+T D S++ S+ S G+++A KG +W DA+ K ++ Sbjct: 215 CTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIW------DAAAGKKLSMLE 268 Query: 205 AHSTYITRILLSSDVKHLATCSADHTARVWSI-DDDFKLETTLDGHQRWVWDCAFSADSA 263 H+ + L+ + + L++ S D I + E L GH++ V +S D Sbjct: 269 GHTARVG--ALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQ 326 Query: 264 YLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVA 299 L + +D+ + +W+ S+ V+QY H +A Sbjct: 327 LLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIA 362 Score = 30.0 bits (66), Expect = 1.3, Method: Compositional matrix adjust. Identities = 58/247 (23%), Positives = 96/247 (38%), Gaps = 35/247 (14%) Query: 70 SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRS-PSIPRNYKHNAPVNEVVIHPNQ 128 S EG +VTSV + + + + G +++WD + + H A V + + Q Sbjct: 226 SVEGD--SVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ 283 Query: 129 GELISCDRDGNIRIWDLGENQCTHQLTP--EDDTSLQ-------SLSMASDGSMLAAANT 179 L S RD I D+ TP + + LQ L ++D +LA+ Sbjct: 284 --LSSGSRDRMILQRDI--------RTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGN 333 Query: 180 KGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATC---SADHTARVWSI 236 VW NH S L PV ++ H + I S L +AD R W+ Sbjct: 334 DNKLLVW---NH---SSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNT 387 Query: 237 DDDFKLETTLDGHQRWVWDCAFSADSAYLVT--ASSDHYVRLWDLSTREIVRQYGGHHKG 294 L+ G Q V + A+S + LV+ S + + +W + V + GH Sbjct: 388 LTGQPLQCIDTGSQ--VCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYR 445 Query: 295 AVCVALN 301 + +A++ Sbjct: 446 VLYLAMS 452 >6N9G-C nrPDB Length = 353 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 49/208 (23%), Positives = 91/208 (43%), Gaps = 11/208 (5%) Query: 74 HRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQ--GE 130 H +++ SF + ++T+S DGT +WDV S + +++ H A V + + P++ Sbjct: 152 HTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNT 211 Query: 131 LISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEM-P 189 +S D +WD+ QC Q ++ + S+ G A+ + C ++++ Sbjct: 212 FVSGGCDKKAMVWDMRSGQCV-QAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRA 270 Query: 190 NHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGH 249 + A + K F A S + S + L D+T VW + ++ + L GH Sbjct: 271 DREVAIYSKESIIFGASS-----VDFSLSGRLLFAGYNDYTINVWDVLKGSRV-SILFGH 324 Query: 250 QRWVWDCAFSADSAYLVTASSDHYVRLW 277 + V S D + S DH +R+W Sbjct: 325 ENRVSTLRVSPDGTAFCSGSWDHTLRVW 352 Score = 54.3 bits (129), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 36/141 (25%), Positives = 56/141 (39%), Gaps = 2/141 (1%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQ-NVRLYDIRTT 63 VS G D W+ +G C + + +S VN + A+ RLYD+R Sbjct: 212 FVSGGCDKKAMVWDMRSGQCVQAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRAD 271 Query: 64 NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDV-RSPSIPRNYKHNAPVNEV 122 + S E +SV F R + D TI VWDV + + + H V+ + Sbjct: 272 REVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTL 331 Query: 123 VIHPNQGELISCDRDGNIRIW 143 + P+ S D +R+W Sbjct: 332 RVSPDGTAFCSGSWDHTLRVW 352 Score = 51.2 bits (121), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 46/198 (23%), Positives = 82/198 (41%), Gaps = 12/198 (6%) Query: 42 NDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSF--QQDNRWMVTSSEDGTI 99 +D ++L +G L+D+ + + SF GH +V + + V+ D Sbjct: 164 SDMQILTASGDGTCALWDVES--GQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKA 221 Query: 100 KVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPED 158 VWD+RS + ++ H + VN V +P+ S D R++DL ++ + E Sbjct: 222 MVWDMRSGQCVQAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKES 281 Query: 159 DT-SLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSS 217 S+ + G +L A VW++ + S L H ++ + +S Sbjct: 282 IIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSIL------FGHENRVSTLRVSP 335 Query: 218 DVKHLATCSADHTARVWS 235 D + S DHT RVW+ Sbjct: 336 DGTAFCSGSWDHTLRVWA 353 Score = 41.2 bits (95), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 45/225 (20%), Positives = 81/225 (36%), Gaps = 45/225 (20%) Query: 70 SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQG 129 + +GH V + + +D R +V+SS+DG + VWD S N +H V P Sbjct: 58 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWD----SFTTNKEH------AVTMP--- 104 Query: 130 ELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMP 189 CT + + + A G +A C V+ + Sbjct: 105 --------------------CTW---------VMACAYAPSGCAIACGGLDNKCSVYPLT 135 Query: 190 NHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGH 249 + + H+ Y++ ++ + T S D T +W ++ +L + GH Sbjct: 136 FDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESG-QLLQSFHGH 194 Query: 250 QRWV--WDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHH 292 V D A S V+ D +WD+ + + V+ + H Sbjct: 195 GADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHE 239 Score = 35.4 bits (80), Expect = 0.029, Method: Compositional matrix adjust. Identities = 14/52 (26%), Positives = 29/52 (55%) Query: 249 HQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVAL 300 H ++ C+F+ ++TAS D LWD+ + ++++ + GH +C+ L Sbjct: 152 HTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDL 203 >5OV3-A nrPDB Length = 381 Score = 54.3 bits (129), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 53/239 (22%), Positives = 100/239 (41%), Gaps = 31/239 (12%) Query: 73 GHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHP-NQGEL 131 H V S+ + +D +V++S D + WDV S + ++ +P+ +V HP +Q ++ Sbjct: 65 AHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKV 124 Query: 132 ISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASD--GSMLAAANTKGNCYVWEMP 189 + C + L +++ H + P DD S ++ + D G + N KG V + Sbjct: 125 LVCPMKSAPVMLTLSDSK--HVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTD 182 Query: 190 NH------------TDASHLKPVTKFRAHSTYIT----RILLSSDVKHLATCSADHTARV 233 + ++ + +K + R S ++ RI+ D + + TC D Sbjct: 183 SQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPE- 241 Query: 234 WSIDDDFKLETTLDGHQRWVW-DCAFSADSAYLVTASS-DHYVRLWDLSTREIVRQYGG 290 ++ D R W C FS D Y+V S+ H + +W+ S +V+ G Sbjct: 242 -------PMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHG 293 >6EOJ-D nrPDB Length = 470 Score = 53.1 bits (126), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 53/279 (18%), Positives = 109/279 (39%), Gaps = 15/279 (5%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTN 64 LV A Y W A + +Q DS V ++ ++D + + + I+ Sbjct: 108 LVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGM----IKIWQ 163 Query: 65 PNPVASFE---GHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVN 120 PN E H ++ ++F ++ VT S+D +K+W+ + R H+ V Sbjct: 164 PNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVK 223 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 HP G + S +D +++WD C + T L++ + G++L A + Sbjct: 224 SCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKD 283 Query: 181 GNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDF 240 +C V+++ +K + R + Y+T + D + + + + + Sbjct: 284 KSCRVFDI-----RYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNL 338 Query: 241 --KLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 + T H + + +++ TA+ D +R W Sbjct: 339 NEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 Score = 52.4 bits (124), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 47/195 (24%), Positives = 83/195 (42%), Gaps = 14/195 (7%) Query: 103 DVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRD----GNIRIWDLGENQCTHQLTPED 158 DV SP I Y + +V+ P I G R+ +L ++ TH + + Sbjct: 34 DVSSPYINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVINL-PSKFTHLSSNKV 92 Query: 159 DTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSD 218 + ++ +G L A G +W +AS T +AH + +T + S D Sbjct: 93 KHVIPAIQWTPEGRRLVVATYSGEFSLW------NASSFTFETLMQAHDSAVTTMKYSHD 146 Query: 219 VKHLATCSADHTARVWSIDDDFKLETTLDG-HQRWVWDCAFSADSAYLVTASSDHYVRLW 277 + + AD ++W +F + +D H + D AFS++ + VT S D+ +++W Sbjct: 147 SDWMISGDADGMIKIWQ--PNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIW 204 Query: 278 DLSTREIVRQYGGHH 292 + S + R GHH Sbjct: 205 NFSNGKQERVLSGHH 219 Score = 51.2 bits (121), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 35/153 (22%), Positives = 66/153 (43%), Gaps = 8/153 (5%) Query: 126 PNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYV 185 P L+ G +W+ + L D+++ ++ + D + + + G + Sbjct: 103 PEGRRLVVATYSGEFSLWN-ASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKI 161 Query: 186 WEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETT 245 W+ PN + + AH+ I + SS+ TCS D+ ++W+ + K E Sbjct: 162 WQ-PNFSMVKEID-----AAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNG-KQERV 214 Query: 246 LDGHQRWVWDCAFSADSAYLVTASSDHYVRLWD 278 L GH V C + + + +AS D+ V+LWD Sbjct: 215 LSGHHWDVKSCDWHPEMGLIASASKDNLVKLWD 247 Score = 36.6 bits (83), Expect = 0.012, Method: Compositional matrix adjust. Identities = 31/147 (21%), Positives = 65/147 (44%), Gaps = 9/147 (6%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQV--NRLEITNDKKLLATAGHQNVRLYDIR 61 ++ SA D+ ++ W+ +G C +I V R + T L+A + ++ R++DIR Sbjct: 233 LIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIR 292 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVT-SSEDGTIKVWD----VRSPSIPRNYKHN 116 + + + + ++ + N M T + DG++K +D + P + Y H+ Sbjct: 293 YSMKELMCVRD--ETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHD 350 Query: 117 APVNEVVIHPNQGELISCDRDGNIRIW 143 + + +P + +D IR W Sbjct: 351 KCITSLSYNPVGHIFATAAKDRTIRFW 377 >5A9Q-0 nrPDB Length = 380 Score = 53.1 bits (126), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 40/147 (27%), Positives = 71/147 (48%), Gaps = 7/147 (4%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQ-VNRLEITNDKKLLATAGHQNVRLYDIRT- 62 +V+ G D I + A RTI ++DS ++ + ++L ++++D R Sbjct: 144 IVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSIGQLKIWDFRQQ 203 Query: 63 -TNPNPVASFEGHRGNVTSVSFQQDNRWMV-TSSEDGTIKVWDVRSPSIPRNY--KHNAP 118 P+ + S G R + V + + +V T +DG + +WDVR ++P + H A Sbjct: 204 GNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAE 263 Query: 119 VNEVVIHPNQGE-LISCDRDGNIRIWD 144 + EV HP+ E L +C DG++ WD Sbjct: 264 MWEVHFHPSNPEHLFTCSEDGSLWHWD 290 Score = 31.6 bits (70), Expect = 0.50, Method: Compositional matrix adjust. Identities = 36/167 (21%), Positives = 70/167 (41%), Gaps = 11/167 (6%) Query: 86 DNRWMVTSSEDGTIKVWDVRSPSIPRNYKH-NAPVNEVVIHPNQGELISCDRDGNIRIWD 144 +N +VT EDG I ++ R + ++ V E+++ + G ++IWD Sbjct: 140 NNPEIVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSIGQLKIWD 199 Query: 145 LGE--NQCTHQLTPEDD-TSLQSLSMASDGS-MLAAANTKGNCYVWEMPNHTDASHLKPV 200 + N+ + L+ D L + + ++A G +W++ T PV Sbjct: 200 FRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGT-----MPV 254 Query: 201 TKFRAHSTYITRILL-SSDVKHLATCSADHTARVWSIDDDFKLETTL 246 + +AH + + S+ +HL TCS D + W D +++L Sbjct: 255 SLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSL 301 >6BX3-B nrPDB Length = 412 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 69/283 (24%), Positives = 118/283 (41%), Gaps = 61/283 (21%) Query: 57 LYDIRTTNP--NPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIP-RNY 113 +YD+ T P P H +TS+++ D R ++TSS D +IK+WD+ PS P + Sbjct: 51 IYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEI 110 Query: 114 KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSM 173 + ++P+ + D C + E D + S S+ Sbjct: 111 RFDSPI------------------WGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASL 152 Query: 174 LAAANTK------GNCYVWEMPNHTDASHLKPVTK-------FRAHSTYITRI-----LL 215 L+ ++ K + YV HT ++ V ++ HS Y T + Sbjct: 153 LSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKIT 212 Query: 216 SSDVKH---------LATCSADHTARVWSI---DDDFKLETTL-----DGHQRWVWDCA- 257 SS++KH LA +D T R + I D++ +E TL D + W+C Sbjct: 213 SSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKLQWNCIL 272 Query: 258 FSADSA-YLVTA---SSDHYVRLWDLSTREIVRQYGGHHKGAV 296 FS ++A YLV + SS H + +W+ ++ +VR G + + Sbjct: 273 FSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELI 315 >4BTS-AR nrPDB Length = 343 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 52/256 (20%), Positives = 112/256 (43%), Gaps = 32/256 (12%) Query: 2 SVILVSAGYDHTIRFWE-------ALTGVCSRTIQHSDSQVNRLEITNDKKL-LATAGHQ 53 S +L+S D T+ W+ G+ + + + V+ L ++ + ++++ + Sbjct: 39 SPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLALSQENCFAISSSWDK 98 Query: 54 NVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSP-SIPRN 112 +RL+D+RT F GH+ V SV+F DNR ++++ + IK+W++ Sbjct: 99 TLRLWDLRTGTT--YKRFVGHQSEVYSVAFSPDNRQILSAGAEREIKLWNILGECKFSSA 156 Query: 113 YKHN----------APVNEVV--IHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDT 160 K N +P+ + + P S DG +++W+ N ++ Sbjct: 157 EKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWN--TNFQIRYTFKAHES 214 Query: 161 SLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVK 220 ++ LS++ +G +A +W++ N T P +F A ST I +I + ++ Sbjct: 215 NVNHLSISPNGKYIATGGKDKKLLIWDILNLT-----YPQREFDAGST-INQIAFNPKLQ 268 Query: 221 HLATCSADHTARVWSI 236 +A D +++++ Sbjct: 269 WVA-VGTDQGVKIFNL 283 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 30/111 (27%), Positives = 51/111 (45%), Gaps = 12/111 (10%) Query: 203 FRAHSTYITRILLSSDVKH------LATCSADHTARVWSIDDD-----FKLE-TTLDGHQ 250 HS ++T I+ K L + S D T +W + ++ F + L GH Sbjct: 17 LEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHN 76 Query: 251 RWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 +V D A S ++ + +++S D +RLWDL T +++ GH VA + Sbjct: 77 HFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFS 127 Score = 42.0 bits (97), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 26/114 (22%), Positives = 53/114 (46%), Gaps = 8/114 (7%) Query: 170 DGSMLAAANTKGNCYVWEMPNHTDASHLK-PVTKFRAHSTYITRILLSSDVKHLATCSAD 228 D +L + + +W++ + P H+ +++ + LS + + S D Sbjct: 38 DSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLALSQENCFAISSSWD 97 Query: 229 HTARVWSIDDDFKLETTLD---GHQRWVWDCAFSADSAYLVTASSDHYVRLWDL 279 T R+W D + TT GHQ V+ AFS D+ +++A ++ ++LW++ Sbjct: 98 KTLRLW----DLRTGTTYKRFVGHQSEVYSVAFSPDNRQILSAGAEREIKLWNI 147 >4XYI-A nrPDB Length = 430 Score = 52.4 bits (124), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 75/301 (24%), Positives = 120/301 (39%), Gaps = 87/301 (28%) Query: 30 HSDSQVNRLE-ITNDKKLLATAG-HQNVRLYDIRTTNPNPVASFEGHR---------GNV 78 H + VN+ + + ++AT G + N ++D+ P+ GH+ G Sbjct: 129 HHEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQ-TGHQACLRHHTSEGFG 187 Query: 79 TSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRN-----------YKHNAPVNEVVIHPN 127 +F Q+ + T +ED +I VWD++ S+ ++H A VN++ H Sbjct: 188 LGWNFIQEGT-LATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQ 246 Query: 128 QGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWE 187 L++ D CT Q+ DT L S S AS C Sbjct: 247 HEALLTSVSD-----------DCTLQI---HDTRLPSSSSAS------------QCV--- 277 Query: 188 MPNHTDASHLKPV--TKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETT 245 +H +PV F + Y+ LAT SADHT +W + + T Sbjct: 278 ------KAHEQPVNGVAFNPFNDYL-----------LATASADHTVALWDLRRLNQRLHT 320 Query: 246 LDGHQRWVWDCAFSA-DSAYLVTASSDHYVRLWDLS--------------TREIVRQYGG 290 L+GH+ V++ +S D LVT+S+D V +WDLS E++ +GG Sbjct: 321 LEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGG 380 Query: 291 H 291 H Sbjct: 381 H 381 Score = 30.4 bits (67), Expect = 0.97, Method: Compositional matrix adjust. Identities = 46/201 (22%), Positives = 77/201 (38%), Gaps = 43/201 (21%) Query: 109 IPRNYKHNAPVNEVVIHPNQGELIS-CDRDGNIRIWDL-----------GENQCTHQLTP 156 I + H VN+ P ++I+ +GN I+DL G C T Sbjct: 124 IVQKIHHEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTS 183 Query: 157 EDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHT----DASHLKPVTKFRAHSTYITR 212 E + +G++ C VW++ + + + PV+ + H+ + Sbjct: 184 EGFG--LGWNFIQEGTLATGTEDTSIC-VWDIKGKSLSLEKSIDVAPVSVYHRHTAVVND 240 Query: 213 ILLSSDVKHLATCSADHTARVWSIDDDFKLET-------------TLDGHQRWVWDCAFS 259 + HL H A + S+ DD L+ + H++ V AF+ Sbjct: 241 LQF-----HLQ-----HEALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFN 290 Query: 260 ADSAYLV-TASSDHYVRLWDL 279 + YL+ TAS+DH V LWDL Sbjct: 291 PFNDYLLATASADHTVALWDL 311 Score = 28.9 bits (63), Expect = 2.6, Method: Compositional matrix adjust. Identities = 30/122 (24%), Positives = 58/122 (47%), Gaps = 21/122 (17%) Query: 4 ILVSAGYDHTIRFWEALTGVCSR--TIQ-HSDSQVNRLEITNDKKLLATAG-HQNVRLYD 59 +L +A DHT+ W+ L + R T++ H D N +D+ +L T+ + V ++D Sbjct: 296 LLATASADHTVALWD-LRRLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWD 354 Query: 60 IRTTN------------PNPVASFEGHRGNVTSVSFQQDNRWMVTS-SEDGTIKVWDVRS 106 + P + GH V+ +S+ +N+W++ S ++D +++W S Sbjct: 355 LSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIW---S 411 Query: 107 PS 108 PS Sbjct: 412 PS 413 >4AEZ-A nrPDB Length = 401 Score = 52.4 bits (124), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 45/186 (24%), Positives = 76/186 (40%), Gaps = 11/186 (5%) Query: 58 YDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK--H 115 +D+R N + + + +GH V ++++ D + + D +++WD RS SIP+ K H Sbjct: 201 HDVRIAN-HQIGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARS-SIPKFTKTNH 258 Query: 116 NAPVNEVVIHPNQGELISCD---RDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGS 172 NA V V P Q L++ D I W+ + + + S S Sbjct: 259 NAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTVDAGSQVTSLIWSPHSKEI 318 Query: 173 MLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTAR 232 M N +W +S L AH T + LS D + L+T ++D + Sbjct: 319 MSTHGFPDNNLSIWSY----SSSGLTKQVDIPAHDTRVLYSALSPDGRILSTAASDENLK 374 Query: 233 VWSIDD 238 W + D Sbjct: 375 FWRVYD 380 Score = 32.7 bits (73), Expect = 0.21, Method: Compositional matrix adjust. Identities = 24/107 (22%), Positives = 44/107 (41%), Gaps = 4/107 (3%) Query: 2 SVILVSAG--YDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGH--QNVRL 57 S +L + G D I FW A TG T+ + + + K++++T G N+ + Sbjct: 272 SNLLATGGGTMDKQIHFWNAATGARVNTVDAGSQVTSLIWSPHSKEIMSTHGFPDNNLSI 331 Query: 58 YDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDV 104 + ++ H V + D R + T++ D +K W V Sbjct: 332 WSYSSSGLTKQVDIPAHDTRVLYSALSPDGRILSTAASDENLKFWRV 378 Score = 30.0 bits (66), Expect = 1.3, Method: Compositional matrix adjust. Identities = 30/153 (19%), Positives = 66/153 (43%), Gaps = 18/153 (11%) Query: 131 LISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPN 190 +++ + N+ +W+ + ++ T + S+ + DGS L+ G ++++ + Sbjct: 106 VVAVALERNVYVWNADSGSVSALAETDESTYVASVKWSHDGSFLSVGLGNGLVDIYDVES 165 Query: 191 HTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDD-DFKLET----T 245 T K R + + R+ S +H+ + + R +I D ++ T Sbjct: 166 QT---------KLRTMAGHQARVGCLSWNRHVLSSGS----RSGAIHHHDVRIANHQIGT 212 Query: 246 LDGHQRWVWDCAFSADSAYLVTASSDHYVRLWD 278 L GH V A+ +D L + +D+ V++WD Sbjct: 213 LQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWD 245 >4BZK-B nrPDB Length = 297 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 59/212 (27%), Positives = 89/212 (41%), Gaps = 25/212 (11%) Query: 90 MVTSSEDGTIKVWDVRSPS---IPRNYKHNAPVNEV-VIHPNQGELI-SCDRDGNIRIWD 144 + T S D TIK+++V + I H PV V HP G ++ SC DG + IW Sbjct: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 Query: 145 LGENQCTHQLTPED--DTSLQSLSMASD--GSMLAAANTKGNCYVWEMP-NHTDASHLKP 199 EN Q+ S+ S+ A G +L A++ G V E N T + + Sbjct: 84 -EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIID 142 Query: 200 VTKFRAHSTYITRILLSSDVKH--------LATCSADHTARVWSIDDD---FKLETTLDG 248 +S + D +H T AD+ ++W + D + LE+TL+G Sbjct: 143 AHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEG 202 Query: 249 HQRWVWDCAFSAD---SAYLVTASSDHYVRLW 277 H WV D A+S +YL + S D +W Sbjct: 203 HSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 234 Score = 37.7 bits (86), Expect = 0.006, Method: Compositional matrix adjust. Identities = 27/76 (35%), Positives = 39/76 (51%), Gaps = 3/76 (3%) Query: 205 AHSTYITRILLSSDVKHLATCSADHTARVWSIDDD-FKLETTLDGHQRWVW--DCAFSAD 261 AH+ I +L K LATCS+D T +++ ++ + KL TL GH+ VW D A Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 262 SAYLVTASSDHYVRLW 277 L + S D V +W Sbjct: 67 GTILASCSYDGKVLIW 82 >2HES-X nrPDB Length = 330 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 49/226 (21%), Positives = 90/226 (39%), Gaps = 18/226 (7%) Query: 66 NPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS-----IPRNYKHNAPVN 120 N + S + ++ + S F Q + T S D IK+ V+ + H + Sbjct: 5 NLIKSLKLYKEKIWSFDFSQGI--LATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIR 62 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGEN------QCTHQLTPEDDTSLQSLSMASDGSML 174 V P+ L + D + IW E+ + + ++ ++ ++DG L Sbjct: 63 SVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYL 122 Query: 175 AAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVW 234 A + + ++WE + ++ + HS + ++ LA+ S D T R+W Sbjct: 123 ATCSRDKSVWIWETDES--GEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIW 180 Query: 235 S-IDDDFKLETTLDGHQRWVWDCAFSADSAY--LVTASSDHYVRLW 277 DDD++ L+GH+ VW F L + S D VR+W Sbjct: 181 KDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVW 226 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 25/88 (28%), Positives = 41/88 (46%), Gaps = 5/88 (5%) Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS-----IPRNYKH 115 RT + +A EGH V V++ D ++ T S D ++ +W+ I +H Sbjct: 93 RTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEH 152 Query: 116 NAPVNEVVIHPNQGELISCDRDGNIRIW 143 + V V+ HP++ L S D +RIW Sbjct: 153 SQDVKHVIWHPSEALLASSSYDDTVRIW 180 Score = 32.7 bits (73), Expect = 0.22, Method: Compositional matrix adjust. Identities = 25/80 (31%), Positives = 36/80 (45%), Gaps = 6/80 (7%) Query: 205 AHSTYITRILLSSDVKHLATCSADHTARVW----SIDDDFKLE--TTLDGHQRWVWDCAF 258 AH I + LA S D T +W S D F+++ ++GH+ V A+ Sbjct: 56 AHKKAIRSVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAW 115 Query: 259 SADSAYLVTASSDHYVRLWD 278 S D YL T S D V +W+ Sbjct: 116 SNDGYYLATCSRDKSVWIWE 135 Score = 28.9 bits (63), Expect = 3.1, Method: Compositional matrix adjust. Identities = 22/83 (26%), Positives = 38/83 (45%), Gaps = 5/83 (6%) Query: 24 CSRTIQHSDSQVNRLEITNDKKLLATAGHQN-VRLYDIRTTNPNPVASFEGHRGNVTSVS 82 C +Q V + + LLA++ + + VR++ + VA GH G V S Sbjct: 145 CISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSD 204 Query: 83 FQQDN---RWMVTSSEDGTIKVW 102 F + R + + S+D T++VW Sbjct: 205 FDKTEGVFR-LCSGSDDSTVRVW 226 >3JRP-A nrPDB Length = 379 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 59/212 (27%), Positives = 89/212 (41%), Gaps = 25/212 (11%) Query: 90 MVTSSEDGTIKVWDVRSPS---IPRNYKHNAPVNEV-VIHPNQGELI-SCDRDGNIRIWD 144 + T S D TIK+++V + I H PV V HP G ++ SC DG + IW Sbjct: 26 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 85 Query: 145 LGENQCTHQLTPED--DTSLQSLSMASD--GSMLAAANTKGNCYVWEMP-NHTDASHLKP 199 EN Q+ S+ S+ A G +L A++ G V E N T + + Sbjct: 86 -EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIID 144 Query: 200 VTKFRAHSTYITRILLSSDVKH--------LATCSADHTARVWSIDDD---FKLETTLDG 248 +S + D +H T AD+ ++W + D + LE+TL+G Sbjct: 145 AHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEG 204 Query: 249 HQRWVWDCAFSAD---SAYLVTASSDHYVRLW 277 H WV D A+S +YL + S D +W Sbjct: 205 HSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 236 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 27/76 (35%), Positives = 39/76 (51%), Gaps = 3/76 (3%) Query: 205 AHSTYITRILLSSDVKHLATCSADHTARVWSIDDD-FKLETTLDGHQRWVW--DCAFSAD 261 AH+ I +L K LATCS+D T +++ ++ + KL TL GH+ VW D A Sbjct: 9 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 68 Query: 262 SAYLVTASSDHYVRLW 277 L + S D V +W Sbjct: 69 GTILASCSYDGKVLIW 84 >5GAN-H nrPDB Length = 465 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 56/238 (23%), Positives = 90/238 (37%), Gaps = 54/238 (22%) Query: 45 KLLATAGHQNV-RLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWD 103 K + +A H RL+D T + EGH V S+SFQ D + + D +WD Sbjct: 278 KFIGSASHDMTWRLWDASTHQELLLQ--EGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWD 335 Query: 104 VRSPS-IPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSL 162 +RS S + H+ P+ V PN ++ + DG I +WD+ Sbjct: 336 IRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDI----------------- 378 Query: 163 QSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSD--VK 220 D L + AH +T++ S + K Sbjct: 379 ---------------------------RKRDEGQLNQIL---AHRNIVTQVRFSKEDGGK 408 Query: 221 HLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWD 278 L +C D+ V+S D K+ +L GH + S +S +LV+ D ++LW+ Sbjct: 409 KLVSCGYDNLINVYSSDTWLKM-GSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 41/212 (19%), Positives = 88/212 (41%), Gaps = 13/212 (6%) Query: 78 VTSVSFQQDNRWMVTSSEDGTIKVWDVRS--PSIPRNYKHNAPVNEVVIHPN-QGELISC 134 +++VS D+ + T S G ++V + ++ P + H + + HP+ ++ISC Sbjct: 178 ISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISC 237 Query: 135 DRDGNIRIWDLGENQCTHQLTPE---DDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNH 191 DG I+ + + +L + + + + G + +A+ +W Sbjct: 238 AEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLW----- 292 Query: 192 TDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQR 251 DAS + + H + + D + + D + +W I K+ TL GH + Sbjct: 293 -DASTHQELLLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKV-MTLAGHSK 350 Query: 252 WVWDCAFSADSAYLVTASSDHYVRLWDLSTRE 283 ++ A+S + + T D + +WD+ R+ Sbjct: 351 PIYTVAWSPNGYQVATGGGDGIINVWDIRKRD 382 Score = 41.6 bits (96), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 34/145 (23%), Positives = 67/145 (46%), Gaps = 11/145 (7%) Query: 162 LQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVT-KFRAHSTYITRILLSSDVK 220 + ++S+++D ++A + G+ V ++ L+P+T K +H I I D Sbjct: 178 ISAVSLSTDDMVVATGSWAGDLQV------LNSQTLQPLTQKLDSHVGKIGAIDWHPDSN 231 Query: 221 -HLATCSADHTARVWSIDDD---FKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRL 276 + +C+ D + + ++ +L L GH+R + D + ++ +AS D RL Sbjct: 232 NQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRL 291 Query: 277 WDLSTREIVRQYGGHHKGAVCVALN 301 WD ST + + GH KG ++ Sbjct: 292 WDASTHQELLLQEGHDKGVFSLSFQ 316 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 26/105 (24%), Positives = 44/105 (41%), Gaps = 5/105 (4%) Query: 197 LKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVW--SIDDDFKLETTLDGHQRWVW 254 L+ + H I+ + K + + S D T R+W S + L+ +GH + V+ Sbjct: 255 LRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQ---EGHDKGVF 311 Query: 255 DCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVA 299 +F D + + + D LWD+ + V GH K VA Sbjct: 312 SLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVA 356 Score = 29.6 bits (65), Expect = 1.6, Method: Compositional matrix adjust. Identities = 31/148 (20%), Positives = 63/148 (42%), Gaps = 10/148 (6%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNV-RLYDIRT 62 ++ S G D W+ +G T+ + + + + +AT G + ++DIR Sbjct: 321 LVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRK 380 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDN--RWMVTSSEDGTIKVWD----VRSPSIPRNYKHN 116 + + HR VT V F +++ + +V+ D I V+ ++ S+ H Sbjct: 381 RDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTWLKMGSLA---GHT 437 Query: 117 APVNEVVIHPNQGELISCDRDGNIRIWD 144 + + I N L+S D +I++W+ Sbjct: 438 DKIISLDISNNSHFLVSGGWDRSIKLWN 465 >5LTD-A nrPDB Length = 525 Score = 51.6 bits (122), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 47/174 (27%), Positives = 75/174 (43%), Gaps = 18/174 (10%) Query: 140 IRIWDLGENQCTHQL-TPEDDTSLQSLSMASDGSMLA-------AANTKGNCYVWEMPNH 191 I I+D+ + H + TP + L +LS +S+ + LA A N + + P Sbjct: 139 IYIYDINNMRLLHTIETPSNPNGLIALSPSSENNYLAYPSPQKLAPNPQTEVTLHSNPQT 198 Query: 192 T--------DASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHT-ARVWSIDDDFKL 242 DA L+P + AH T + I LS D LAT S T RV+S+ KL Sbjct: 199 VRNGDVIIFDAKTLQPTSVIEAHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKL 258 Query: 243 ETTLDG-HQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGA 295 G + ++ AFS D+ +++ +S+ V ++ L E +K A Sbjct: 259 YQFRRGTYPTKIYSLAFSPDNRFVIASSATETVHIFRLGEEEAANTIKSANKKA 312 Score = 35.8 bits (81), Expect = 0.024, Method: Compositional matrix adjust. Identities = 24/116 (20%), Positives = 51/116 (43%), Gaps = 18/116 (15%) Query: 49 TAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGT---------- 98 T + +V ++D +T P V E HR ++ +++ +D + T+S+ GT Sbjct: 198 TVRNGDVIIFDAKTLQPTSV--IEAHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATG 255 Query: 99 IKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQL 154 IK++ R + P + + P+ +I+ + I+ LGE + + + Sbjct: 256 IKLYQFRRGTYPTK------IYSLAFSPDNRFVIASSATETVHIFRLGEEEAANTI 305 >3JRO-A nrPDB Length = 753 Score = 50.8 bits (120), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 59/212 (27%), Positives = 89/212 (41%), Gaps = 25/212 (11%) Query: 90 MVTSSEDGTIKVWDVRSPS---IPRNYKHNAPVNEV-VIHPNQGELI-SCDRDGNIRIWD 144 + T S D TIK+++V + I H PV V HP G ++ SC DG + IW Sbjct: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 Query: 145 LGENQCTHQLTPED--DTSLQSLSMASD--GSMLAAANTKGNCYVWEMP-NHTDASHLKP 199 EN Q+ S+ S+ A G +L A++ G V E N T + + Sbjct: 84 -EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIID 142 Query: 200 VTKFRAHSTYITRILLSSDVKH--------LATCSADHTARVWSIDDD---FKLETTLDG 248 +S + D +H T AD+ ++W + D + LE+TL+G Sbjct: 143 AHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEG 202 Query: 249 HQRWVWDCAFSAD---SAYLVTASSDHYVRLW 277 H WV D A+S +YL + S D +W Sbjct: 203 HSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 234 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 27/76 (35%), Positives = 39/76 (51%), Gaps = 3/76 (3%) Query: 205 AHSTYITRILLSSDVKHLATCSADHTARVWSIDDD-FKLETTLDGHQRWVW--DCAFSAD 261 AH+ I +L K LATCS+D T +++ ++ + KL TL GH+ VW D A Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 262 SAYLVTASSDHYVRLW 277 L + S D V +W Sbjct: 67 GTILASCSYDGKVLIW 82 >5WJC-A nrPDB Length = 430 Score = 50.8 bits (120), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 72/303 (23%), Positives = 119/303 (39%), Gaps = 82/303 (27%) Query: 25 SRTIQHSDSQVNRLEITNDK-KLLATAGHQ-NVRLYD------IRTTNPNPVASFEGHRG 76 S+ I H D VNR K +++AT G N ++D + T P A +GH Sbjct: 125 SQKIPH-DGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTA 183 Query: 77 NVTSVSFQQDNRW-MVTSSEDGTIKVWDVRSPS-----------IPRNYKHNAPVNEVVI 124 + + + + T +ED I +WDV++ S I + ++H VN+V Sbjct: 184 EGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQF 243 Query: 125 HPNQGELI-SCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNC 183 HP L+ S D ++I D +L PE++ + A ++ A A N Sbjct: 244 HPQHEALLASVSDDCTLQIHDT-------RLNPEEEAP--KVIQAHSKAINAVAINPFND 294 Query: 184 YVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLE 243 Y+ LAT SAD T +W + + ++ Sbjct: 295 YL------------------------------------LATASADKTVALWDLRNPYQRL 318 Query: 244 TTLDGHQRWVWDCAFSA-DSAYLVTASSDHYVRLWDLS--------------TREIVRQY 288 TL+GH+ V+ +S D L ++S+D V +WDL + E++ + Sbjct: 319 HTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDGSPELLFMH 378 Query: 289 GGH 291 GGH Sbjct: 379 GGH 381 Score = 31.6 bits (70), Expect = 0.39, Method: Compositional matrix adjust. Identities = 49/186 (26%), Positives = 79/186 (42%), Gaps = 29/186 (15%) Query: 5 LVSAGYDHTIRFW----EALTGVCSRTIQHSDSQVNRLEITND-------KKLLATAGHQ 53 L + D I W ++ T ++ I +I ND + LLA+ Sbjct: 198 LATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEALLASVSDD 257 Query: 54 -NVRLYDIRTTNPNPVAS--FEGHRGNVTSVSFQQDNRWMV-TSSEDGTIKVWDVRSP-- 107 ++++D R NP A + H + +V+ N +++ T+S D T+ +WD+R+P Sbjct: 258 CTLQIHDTRL-NPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALWDLRNPYQ 316 Query: 108 SIPRNYKHNAPVNEVVIHP-NQGELISCDRDGNIRIWDL---GENQCTHQLTPED--DTS 161 + H V + P ++ L S D + IWDL GE Q TPED D S Sbjct: 317 RLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQ-----TPEDAEDGS 371 Query: 162 LQSLSM 167 + L M Sbjct: 372 PELLFM 377 >3ACP-A nrPDB Length = 417 Score = 50.4 bits (119), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 30/116 (25%), Positives = 53/116 (45%), Gaps = 5/116 (4%) Query: 72 EGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQGE 130 + H +T + F +++SS+D +K+W V+ S PR H A V ++ I Sbjct: 133 QAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTLIGHRATVTDIAIIDRGRN 192 Query: 131 LISCDRDGNIRIWDLGENQCTHQL----TPEDDTSLQSLSMASDGSMLAAANTKGN 182 ++S DG IR+W+ G H P D + +L + +D + + +K N Sbjct: 193 VLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALFVGTDRQLHEISTSKKN 248 Score = 40.4 bits (93), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 46/100 (46%), Gaps = 4/100 (4%) Query: 204 RAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSA 263 +AH + IT++ + L + S D ++WS+ D TL GH+ V D A Sbjct: 133 QAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSN-PRTLIGHRATVTDIAIIDRGR 191 Query: 264 YLVTASSDHYVRLWDLSTREIVRQYG---GHHKGAVCVAL 300 +++AS D +RLW+ T + + H G +AL Sbjct: 192 NVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIAL 231 Score = 29.6 bits (65), Expect = 1.7, Method: Compositional matrix adjust. Identities = 35/149 (23%), Positives = 57/149 (38%), Gaps = 22/149 (14%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTN 64 ++SA D TIR WE TG TI + + N + N L Q L++I T+ Sbjct: 193 VLSASLDGTIRLWECGTGT---TIHTFNRKENPHDGVNSIALFVGTDRQ---LHEISTSK 246 Query: 65 PNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDV--RSPSIPRNYKHNAPVNEV 122 N ++ F ++++ G I V +V + +I K N + Sbjct: 247 KN-------------NLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLPSKFTCSCNSL 293 Query: 123 VIHPNQGELISCD-RDGNIRIWDLGENQC 150 + N I +G + WDL +C Sbjct: 294 TVDGNNANYIYAGYENGMLAQWDLRSPEC 322 >6ELZ-p nrPDB Length = 460 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 49/149 (32%), Positives = 74/149 (49%), Gaps = 15/149 (10%) Query: 7 SAGYDHTIRFWEALTGVC--SRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTN 64 S DHTI+ W+ +T C +RT +S + +L N ++A H + L+D R Sbjct: 305 SVSQDHTIKTWDLVTARCIDTRTTSYSLLSIAQLSTLNLLACGSSARH--ITLHDPRVGA 362 Query: 65 PNPVASFE--GHRGNVTSVSFQQDNRWMVTS-SEDGTIKVWDVRSPS----IPRNYKH-N 116 + V + GH+ V+S+ +N +++ S S DGT+KVWDVRS S I R K Sbjct: 363 SSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITREDKSVQ 422 Query: 117 APVNEVVIHPNQGE---LISCDRDGNIRI 142 VN+ V E +IS +D I+I Sbjct: 423 KGVNDKVFAVKWAEKVGIISAGQDKKIQI 451 Score = 35.4 bits (80), Expect = 0.030, Method: Compositional matrix adjust. Identities = 65/320 (20%), Positives = 119/320 (37%), Gaps = 74/320 (23%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTN 64 LVSAG D T+R W+ +D KL + Q ++ + Sbjct: 158 LVSAGNDRTLRLWKTK--------------------NDDLKLTSQQQAQEDDDDEVNIED 197 Query: 65 PNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW--------------DVRSP--- 107 +A EGH+ V S+ DN ++++S D +I W D+ +P Sbjct: 198 GKTLAILEGHKAPVVSIDV-SDNSRILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNK 256 Query: 108 ----------------SIPRNY------KHNAPVNEVVIHPNQGEL-ISCDRDGNIRIWD 144 +I R H APV +V+ + S +D I+ WD Sbjct: 257 ISTAARKRRKLTMKDGTIRRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWD 316 Query: 145 LGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFR 204 L +C T SL S++ S ++LA ++ + + + AS + Sbjct: 317 LVTARCIDTRTTS--YSLLSIAQLSTLNLLACGSSARHITLHD--PRVGASSKVTQQQLI 372 Query: 205 AHSTYITRILLSSDVKHLATCSADH--TARVWSIDDDFKLETTL---DGHQRWVWDCAFS 259 H +++ + + +++ CS H T +VW + + T Q+ V D F+ Sbjct: 373 GHKNFVSSLDTCPENEYIL-CSGSHDGTVKVWDVRSTSPMYTITREDKSVQKGVNDKVFA 431 Query: 260 ---ADSAYLVTASSDHYVRL 276 A+ +++A D +++ Sbjct: 432 VKWAEKVGIISAGQDKKIQI 451 Score = 32.0 bits (71), Expect = 0.32, Method: Compositional matrix adjust. Identities = 27/101 (26%), Positives = 49/101 (48%), Gaps = 5/101 (4%) Query: 44 KKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWD 103 KK L++ NV Y P+ + SF V+S+ ++ +++ S DG ++ WD Sbjct: 74 KKGLSSEASLNVE-YTRAILPPSYLNSFSNEDW-VSSLDVGDGSKHIISGSYDGIVRTWD 131 Query: 104 VRSPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDGNIRIW 143 + S ++ + Y H+ P+ V N L+S D +R+W Sbjct: 132 L-SGNVQKQYSGHSGPIRAVKYISNT-RLVSAGNDRTLRLW 170 Score = 30.8 bits (68), Expect = 0.73, Method: Compositional matrix adjust. Identities = 15/43 (34%), Positives = 23/43 (53%), Gaps = 1/43 (2%) Query: 249 HQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGH 291 ++ WV S ++++ S D VR WDLS + +QY GH Sbjct: 102 NEDWVSSLDVGDGSKHIISGSYDGIVRTWDLSG-NVQKQYSGH 143 >5OQL-X nrPDB Length = 630 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 29/103 (28%), Positives = 45/103 (43%), Gaps = 1/103 (0%) Query: 193 DASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRW 252 +A+ LKP+ F H +T + L +CS D T +VWS+D+ +E TL GHQ Sbjct: 274 NAADLKPIKAFTQHRDAVTGLAFRRGTNQLYSCSKDRTVKVWSLDELAYVE-TLFGHQDE 332 Query: 253 VWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGA 295 + D + + D R W + + GG G+ Sbjct: 333 ILDIDALGQERCVSVGARDRTARYWKVPEESQLVFRGGGEGGS 375 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 19/67 (28%), Positives = 35/67 (52%), Gaps = 1/67 (1%) Query: 38 LEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDG 97 ++ + D K + T G RL + P+ +F HR VT ++F++ + + S+D Sbjct: 252 VKASQDGKFVVTGGADK-RLVVYNAADLKPIKAFTQHRDAVTGLAFRRGTNQLYSCSKDR 310 Query: 98 TIKVWDV 104 T+KVW + Sbjct: 311 TVKVWSL 317 Score = 36.6 bits (83), Expect = 0.015, Method: Compositional matrix adjust. Identities = 25/124 (20%), Positives = 51/124 (41%), Gaps = 2/124 (1%) Query: 70 SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQ 128 +++GH V QD +++VT D + V++ + + +H V + Sbjct: 241 TYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLKPIKAFTQHRDAVTGLAFRRGT 300 Query: 129 GELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEM 188 +L SC +D +++W L E L D L ++ + + A + Y W++ Sbjct: 301 NQLYSCSKDRTVKVWSLDELAYVETLFGHQDEILDIDALGQERCVSVGARDRTARY-WKV 359 Query: 189 PNHT 192 P + Sbjct: 360 PEES 363 >4G56-B nrPDB Length = 357 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 34/127 (26%), Positives = 65/127 (51%), Gaps = 7/127 (5%) Query: 23 VCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNP---NPVASFEGHRGNVT 79 +C+ +Q +++ V + ++K +L + V L++I N A +E H V Sbjct: 86 LCTAGVQ-TEAGVTDVAWVSEKGILVASDSGAVELWEILEKESLLVNKFAKYE-HDDIVK 143 Query: 80 SVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGEL-ISCDRD 137 ++S D V+ +D ++KVWD+ ++ ++Y H++ VN V P + + +SC D Sbjct: 144 TLSVFSDGTQAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGED 203 Query: 138 GNIRIWD 144 G I +WD Sbjct: 204 GRILLWD 210 Score = 33.1 bits (74), Expect = 0.14, Method: Compositional matrix adjust. Identities = 13/40 (32%), Positives = 21/40 (52%) Query: 260 ADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVA 299 +D V+ D V++WDLS + +++ Y H CVA Sbjct: 149 SDGTQAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVA 188 >5CXC-A nrPDB Length = 510 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 74/298 (24%), Positives = 113/298 (37%), Gaps = 52/298 (17%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQ-----HSDSQVNRLEITNDKKLLATAGH-QNVRLY 58 ++SA YD +R W A V + + H+ S +T+D+ LA+AG + VR++ Sbjct: 161 VLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSDR--LASAGMDRTVRVW 218 Query: 59 -----DIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIP--- 110 D T P GH G+V + ++ ++T+S DG I W S P Sbjct: 219 KYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSASKASAPEPD 278 Query: 111 ----------RNYK------------------HNAPVNEVVIHPNQGELI-SCDRDGNIR 141 + K H AP + P + S +D +R Sbjct: 279 ASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQDHTVR 338 Query: 142 IWDLGENQCTHQLT-PEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPV 200 DL Q LT SL +L+ A S L AA T P + A+ V Sbjct: 339 TLDLTTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDPRASSAT--TSV 396 Query: 201 TKFRAHSTYITRILLSSDVKH-LATCSADHTARVW---SIDDDFKLETTLDGHQRWVW 254 R H+ + + S + ++ L + S D T RVW S+ K E +L G V+ Sbjct: 397 MTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKEEGSLGGVSEPVY 454 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 34/109 (31%), Positives = 55/109 (50%), Gaps = 6/109 (5%) Query: 4 ILVSAGYDHTIRFWEALTG--VCSRTIQHSDSQVNRLEITNDKKLLATAG--HQNVRLYD 59 + SA DHT+R + TG V + T+ H ++ L L AG +++ + D Sbjct: 327 VAYSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVD 386 Query: 60 IRTTNP-NPVASFEGHRGNVTSVSFQQDNRW-MVTSSEDGTIKVWDVRS 106 R ++ V + GH V S+S +N + +V+ S DGT +VWD+RS Sbjct: 387 PRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRS 435 Score = 37.4 bits (85), Expect = 0.008, Method: Compositional matrix adjust. Identities = 44/198 (22%), Positives = 75/198 (37%), Gaps = 39/198 (19%) Query: 124 IHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMAS--DGSMLAAANTKG 181 + P Q ++S DG +RIW+ + + S+ A LA+A Sbjct: 154 VQPGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSDRLASAGMDR 213 Query: 182 NCYVWEMPNHTDASH----LKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWS-- 235 VW+ +T++ H LKP + H+ + + + KH+ T SAD WS Sbjct: 214 TVRVWK---YTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSAS 270 Query: 236 ----------------IDDDFKLETTLDGHQR---WVWDCAFSADSAYLV---------T 267 + K +++ QR +W + +A + + Sbjct: 271 KASAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYS 330 Query: 268 ASSDHYVRLWDLSTREIV 285 AS DH VR DL+T ++V Sbjct: 331 ASQDHTVRTLDLTTGQVV 348 >5OQL-J nrPDB Length = 912 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 27/101 (26%), Positives = 48/101 (47%), Gaps = 15/101 (14%) Query: 205 AHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFS----- 259 AH I + +S + K A+ S D T ++W ++ +++ L GH+R VW F+ Sbjct: 542 AHDKDINALDISPNGKLFASASQDKTVKIWDVEK-LEVQGILRGHKRGVWTVRFAPLNTP 600 Query: 260 ---------ADSAYLVTASSDHYVRLWDLSTREIVRQYGGH 291 + ++T S D ++LW+LS +R + GH Sbjct: 601 VIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGH 641 Score = 47.4 bits (111), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 47/220 (21%), Positives = 81/220 (36%), Gaps = 56/220 (25%) Query: 73 GHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRS---PSIPRNYKHN------APVNEVV 123 H ++ ++ + + ++S+D T+K+WDV I R +K AP+N V Sbjct: 542 AHDKDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTPV 601 Query: 124 IHPNQGEL------ISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAA 177 I QG + ++ D I++W+L + C L+ Sbjct: 602 IQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLK-------------- 647 Query: 178 NTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSID 237 VW + D+ +TK + A+ AD +VW + Sbjct: 648 ------VVWLHISRDDS-----ITKTKVQ---------------FASAGADTLVKVWDAN 681 Query: 238 DDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 + E TLD H+ +W A + + L +A SD V W Sbjct: 682 TG-ETECTLDNHEDRLWTLAVHSKTNILASAGSDSKVTFW 720 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 72/374 (19%), Positives = 132/374 (35%), Gaps = 78/374 (20%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEI-----------TNDKKLLATA 50 S +L + D I+ W+ + G + T+ V+ L +N K + Sbjct: 123 STLLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHFFEIAVTAESQSSNKKPKKGSR 182 Query: 51 GHQN--------------------VRLYDI--RTTNP---NPVASFEGHRGNVTSVSFQQ 85 QN +R++D+ RTT P +P E H NV +++ Sbjct: 183 KGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSP 242 Query: 86 DNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGE-LISCDRDGNIRIWD 144 + +++ S D T+ +W R + E V N+G+ + S G +RIWD Sbjct: 243 EQHALLSGSRDKTMTLWLWRDGIWQGTPMLRHELLESVGFLNEGKWMYSAGTSGVLRIWD 302 Query: 145 LGENQCTHQLTPEDDTSLQSLSMAS-----DGSMLAAANTKGNCYVWEMPNHTDASH--- 196 H++T + D + ++ S + S++ A ++ +P+ D Sbjct: 303 ---TTTHHEITKKQDAKSEGEAILSAVSLPERSLILCAQADFTLVLYRVPSPADVVSSSE 359 Query: 197 ---LKPVTKFRA-HSTYITRILLSSDVKHLATCSADHTARVWSIDD-------------- 238 L+P + H + + D +A + R+ S+ D Sbjct: 360 GILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSG 419 Query: 239 -----DFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDL----STREIVRQYG 289 D L L GH+ V ++ + S D+ RLW + ++ + Sbjct: 420 SYFGHDVAL---LKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYTCYAVFT 476 Query: 290 GHHKGAVCVALNDV 303 GH + VAL V Sbjct: 477 GHLESVGAVALPKV 490 Score = 37.4 bits (85), Expect = 0.008, Method: Compositional matrix adjust. Identities = 57/290 (19%), Positives = 109/290 (37%), Gaps = 26/290 (8%) Query: 21 TGVCSRTIQHSDSQVNRLEIT-NDKKLLATAGHQNVRLY------DIRTTNPNPVASFEG 73 TG IQ ++ L IT + L+ + +R+Y D + P V + + Sbjct: 50 TGKRLAEIQGDGEPISTLTITPSGSHLIVCSRSLTMRIYSLAISPDYDSVEPTLVRTTKP 109 Query: 74 HRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELIS 133 H V ++ + + + T + DG IK+WD+ + V H G + Sbjct: 110 HATPVVVLAVDRTSTLLATGAADGAIKIWDI--------------IGGYVTHTVSGPSVL 155 Query: 134 CDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGS--MLAAANTKGNCYVWEMPNH 191 I E+Q +++ + Q+ S LA G ++++ Sbjct: 156 VSALHFFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKR 215 Query: 192 TDAS-HLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQ 250 T + P K AH + + I S + L + S D T +W D T + H+ Sbjct: 216 TTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDGIWQGTPMLRHE 275 Query: 251 RWVWDCAFSADSAYLVTASSDHYVRLWDLST-REIVRQYGGHHKGAVCVA 299 + F + ++ +A + +R+WD +T EI ++ +G ++ Sbjct: 276 -LLESVGFLNEGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILS 324 Score = 27.7 bits (60), Expect = 5.9, Method: Compositional matrix adjust. Identities = 15/49 (30%), Positives = 27/49 (55%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG 51 V SAG D ++ W+A TG T+ + + ++ L + + +LA+AG Sbjct: 664 VQFASAGADTLVKVWDANTGETECTLDNHEDRLWTLAVHSKTNILASAG 712 >4YCZ-A nrPDB Length = 876 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 59/265 (22%), Positives = 113/265 (42%), Gaps = 34/265 (12%) Query: 44 KKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSE--DGTIKV 101 ++L + + +++++I + +GH G V VS+ + +S DG + + Sbjct: 31 RRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPKYGNILASAGYDGKVLI 90 Query: 102 WDVRSPSIPRNYK---HNAPVNEVVIHPNQ-GELISC-DRDGNIRIWDLGENQCTHQLTP 156 W + + R + H A VN V P++ G L++C DGN+ + + +N H + Sbjct: 91 WRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNVSVLEFRDNSWEHSIFH 150 Query: 157 EDDTSLQSLSMA---SDGSMLAA---ANTKGN-----------CYVWEMPNHTDASHLK- 198 + S+S A S GS++++ + GN +W T+ L+ Sbjct: 151 AHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLER 210 Query: 199 -PVTKFRAHSTYITRILLSSDV---KHLATCSADHTARVWSIDDDFKLE--TTLDGHQRW 252 P+T H+ ++ + S V ++A+ S D T R+W+ D L+ + Sbjct: 211 EPLT---GHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPANPLQWNCKVLNFDAA 267 Query: 253 VWDCAFSADSAYLVTASSDHYVRLW 277 VW ++S L + D+ V LW Sbjct: 268 VWRVSWSLSGNVLAASGGDNKVTLW 292 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 58/223 (26%), Positives = 96/223 (43%), Gaps = 37/223 (16%) Query: 87 NRWMVTSSEDGTIKVWDVRSPS--IPRNYK-HNAPVNEVV-IHPNQGELI-SCDRDGNIR 141 R + T S D TIK++++ + + K H+ V V HP G ++ S DG + Sbjct: 30 GRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPKYGNILASAGYDGKVL 89 Query: 142 IWDL--GENQCTHQLTP-EDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLK 198 IW G Q + ++ S S G +LA A++ GN V E +++ + Sbjct: 90 IWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNVSVLEFRDNSWEHSI- 148 Query: 199 PVTKFRAHSTYITRI----------LLSSDV-------KHLATCSADHTARVWSID---D 238 F AH + + ++SS + T +D+ ++W+ D + Sbjct: 149 ----FHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATN 204 Query: 239 DFKLE-TTLDGHQRWVWDCAFSA---DSAYLVTASSDHYVRLW 277 +KLE L GH WV D A+S +Y+ +AS D VR+W Sbjct: 205 TYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIW 247 Score = 35.0 bits (79), Expect = 0.036, Method: Compositional matrix adjust. Identities = 26/77 (33%), Positives = 37/77 (48%), Gaps = 5/77 (6%) Query: 205 AHSTYITRILLSSDVKHLATCSADHTARVWSIDDDF-KLETTLDGHQRWVWDCAFSADSA 263 H I +L + LATCS+D T +++ I+ + +L TL GH VW C A Sbjct: 16 GHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVW-CVSWAHPK 74 Query: 264 Y---LVTASSDHYVRLW 277 Y L +A D V +W Sbjct: 75 YGNILASAGYDGKVLIW 91 Score = 30.4 bits (67), Expect = 1.00, Method: Compositional matrix adjust. Identities = 54/219 (24%), Positives = 81/219 (36%), Gaps = 38/219 (17%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHS--DSQVNRLEITNDKK--LLATAGHQ-NVRLY 58 IL SAGYD + W L G R + + VN + + + LLA A NV + Sbjct: 78 ILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNVSVL 137 Query: 59 DIRTTNPNPVASFEGHRGNVTSVSFQQ-----------------DNRWMVTSSEDGTIKV 101 + R N + F H V SVS+ NR VT D +K+ Sbjct: 138 EFR-DNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNALKI 196 Query: 102 WDVRSPSIPRNYK--------HNAPVNEVVIHP---NQGELISCDRDGNIRIW--DLGEN 148 W P+ YK H V +V P + + S D +RIW D Sbjct: 197 W-AYDPAT-NTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPANP 254 Query: 149 QCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWE 187 + D ++ +S + G++LAA+ +W+ Sbjct: 255 LQWNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVTLWK 293 >4J0W-A nrPDB Length = 343 Score = 47.8 bits (112), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 44/233 (18%), Positives = 87/233 (37%), Gaps = 20/233 (8%) Query: 56 RLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-K 114 +L+ I GH +V ++ D +++ + I +W+ +S + Sbjct: 48 KLHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTG 107 Query: 115 HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSML 174 H V+ + +L S D ++++W++ EN L D ++ +L S + Sbjct: 108 HRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQD-AVAALDALSRECCV 166 Query: 175 AAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVW 234 A G VW++P + F H I I L ++ +H+ + + D + +W Sbjct: 167 TAGGRDGTVRVWKIPEESQ-------LVFYGHQGSIDCIHLINE-EHMVSGADDGSVALW 218 Query: 235 SIDDDFKLETTLDGHQR----------WVWDCAFSADSAYLVTASSDHYVRLW 277 + L + H W+ A ++ + T S VRLW Sbjct: 219 GLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLW 271 Score = 47.4 bits (111), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 45/217 (20%), Positives = 100/217 (46%), Gaps = 14/217 (6%) Query: 33 SQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVT 92 S V + I++D K LA+ G ++ + + + +F GHR V+ ++F++ + + Sbjct: 68 SHVLCMAISSDGKYLAS-GDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYS 126 Query: 93 SSEDGTIKVWDVRSPS-IPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCT 151 +S D ++KVW+V S + + H V + + + + RDG +R+W + E + Sbjct: 127 TSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEE--S 184 Query: 152 HQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHST--- 208 + S+ + + ++ M++ A+ G+ +W + + + R Sbjct: 185 QLVFYGHQGSIDCIHLINEEHMVSGAD-DGSVALWGLSKKRPLALQREAHGLRGEPGLEQ 243 Query: 209 --YITRI--LLSSDVKHLATCSADHTARVWSIDDDFK 241 +I+ + LL++D+ +AT S R+W + F+ Sbjct: 244 PFWISSVAALLNTDL--VATGSHSSCVRLWQCGEGFR 278 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 52/224 (23%), Positives = 91/224 (40%), Gaps = 22/224 (9%) Query: 71 FEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS----IPRNYK--------HNAP 118 GH+ ++T + D+ + ++++D +I W V S IPR K H++ Sbjct: 10 LRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSH 69 Query: 119 VNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAAN 178 V + I + L S DR I IW+ Q + T D ++ L+ L + + Sbjct: 70 VLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRD-AVSGLAFRRGTHQLYSTS 128 Query: 179 TKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDD 238 + VW + ++ V H + + S + D T RVW I + Sbjct: 129 HDRSVKVWNVAENSY------VETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPE 182 Query: 239 DFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTR 282 + +L GHQ + DC + ++V+ + D V LW LS + Sbjct: 183 ESQL--VFYGHQGSI-DCIHLINEEHMVSGADDGSVALWGLSKK 223 Score = 37.0 bits (84), Expect = 0.009, Method: Compositional matrix adjust. Identities = 36/139 (25%), Positives = 62/139 (44%), Gaps = 9/139 (6%) Query: 154 LTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRI 213 +TP DD+++ S A D S++ + G + +P + KP HS+++ + Sbjct: 22 VTP-DDSAI--FSAAKDCSIIKWSVESGR-KLHVIPRAKKGAEGKP----PGHSSHVLCM 73 Query: 214 LLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHY 273 +SSD K+LA+ +W L T GH+ V AF + L + S D Sbjct: 74 AISSDGKYLASGDRSKLILIWEAQSCQHL-YTFTGHRDAVSGLAFRRGTHQLYSTSHDRS 132 Query: 274 VRLWDLSTREIVRQYGGHH 292 V++W+++ V GH Sbjct: 133 VKVWNVAENSYVETLFGHQ 151 Score = 33.1 bits (74), Expect = 0.14, Method: Compositional matrix adjust. Identities = 22/99 (22%), Positives = 41/99 (41%), Gaps = 10/99 (10%) Query: 203 FRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKL----------ETTLDGHQRW 252 R H IT ++++ D + + + D + WS++ KL E GH Sbjct: 10 LRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSH 69 Query: 253 VWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGH 291 V A S+D YL + + +W+ + + + + GH Sbjct: 70 VLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGH 108 >4XFV-A nrPDB Length = 792 Score = 47.8 bits (112), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 62/272 (22%), Positives = 102/272 (37%), Gaps = 61/272 (22%) Query: 31 SDSQVNRLEITNDKKLLATAGHQNVRLYD-IRTTNPNPVASFEGHRGNVTSVSFQQDNRW 89 ++ Q +I KK++A + + L+D I N A+ +GH VT V F D+ + Sbjct: 18 ANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDF 77 Query: 90 MVTSSEDGTIKVW---DVRSPSIPRNYKHNAPVNEVVIHPNQGELISCD-RDGNIRIWDL 145 MV++SED +K+W D + +H + +V LIS DG I IW Sbjct: 78 MVSASEDHHVKIWKFTDYSHLQCIQTIQHYS--KTIVALSALPSLISVGCADGTISIWRQ 135 Query: 146 G----ENQCTHQLTPEDDTSLQ---SLSMASDGS-MLAAANTKGNCYVWEMPNHTDASHL 197 E H+ T + SLS + +LA T N ++ Sbjct: 136 NIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFI------------ 183 Query: 198 KPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCA 257 + IL S ++ ++ L+GH+ WV A Sbjct: 184 ------------ASFILSDSGIEKC------------------RVVAELEGHEDWVKSLA 213 Query: 258 F----SADSAYLVTASSDHYVRLWDLSTREIV 285 F + L + S D Y+RLW + +++ Sbjct: 214 FRHQETPGDYLLCSGSQDRYIRLWRIRINDLI 245 Score = 35.8 bits (81), Expect = 0.022, Method: Compositional matrix adjust. Identities = 38/140 (27%), Positives = 60/140 (42%), Gaps = 16/140 (11%) Query: 152 HQLTPEDDT------SLQSLSMASDGSMLAAANTKGNCY--VWEMPNHTDASHLKPVTKF 203 H L PE + + L ++ D ++A+A N V + + + +KP F Sbjct: 549 HLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPF 608 Query: 204 RAHSTYITRILLSSDVKHLATCSADHTARVWS---IDDDFKLETTLDG-HQRWVWDCAFS 259 HS ITR+ S D K L + D +W D+ F+L + H R +WD ++ Sbjct: 609 --HSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWA 666 Query: 260 A--DSAYLVTASSDHYVRLW 277 VTAS D V++W Sbjct: 667 PLEFGNVFVTASRDKTVKVW 686 Score = 32.0 bits (71), Expect = 0.38, Method: Compositional matrix adjust. Identities = 36/155 (23%), Positives = 58/155 (37%), Gaps = 20/155 (12%) Query: 107 PSIPRNYKHNAPVNEVVIHPNQGELISCDRDGN-----IRIWDLGENQCTHQLTPEDDTS 161 P + + Y H + + I P+Q + S R N IRI+ P + Sbjct: 553 PEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLT 612 Query: 162 LQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKH 221 + L + DG L + +WE + L +F+ + TRI+ +D Sbjct: 613 ITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFEL----RFKNEKPH-TRIIWDADWAP 667 Query: 222 L------ATCSADHTARVW----SIDDDFKLETTL 246 L T S D T +VW DD+ LE ++ Sbjct: 668 LEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASI 702 >4E5Z-B nrPDB Length = 436 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 28/98 (28%), Positives = 44/98 (44%), Gaps = 5/98 (5%) Query: 74 HRGNVTSVSFQQDNRW-MVTSSEDGTIKVWDVR----SPSIPRNYKHNAPVNEVVIHPNQ 128 H+ VT V+ W + T+S D T+K+WD+R S + H PVN P+ Sbjct: 249 HKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDG 308 Query: 129 GELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLS 166 L++ D+ IR++ + C L P Q L+ Sbjct: 309 ARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLT 346 Score = 31.2 bits (69), Expect = 0.61, Method: Compositional matrix adjust. Identities = 26/103 (25%), Positives = 43/103 (41%), Gaps = 13/103 (12%) Query: 190 NHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTA--RVWSIDDDFKLETTLD 247 N AS ++ T+ + I R+ SSD ++ CS D +A R+ D+ L+ Sbjct: 178 NQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLN 237 Query: 248 GHQRWVWDCAFSADSA-----------YLVTASSDHYVRLWDL 279 + +W+ +L TAS D V++WDL Sbjct: 238 MDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDL 280 >2YNP-A nrPDB Length = 604 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 46/228 (20%), Positives = 89/228 (39%), Gaps = 14/228 (6%) Query: 70 SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQ 128 +F V + F W++T+ G +++W+ + R+ + PV + Sbjct: 8 TFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIARK 67 Query: 129 GELISCDRDGNIRIWDL--GENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVW 186 +I D IR+++ GE + P+ ++S+++ + + + +W Sbjct: 68 NWIIVGSDDFRIRVFNYNTGEKVVDFEAHPD---YIRSIAVHPTKPYVLSGSDDLTVKLW 124 Query: 187 EMPNHTDASHLKPVTKFRAHSTYITRILLS-SDVKHLATCSADHTARVWSIDDDFKLETT 245 N+ F H ++ + + D A+ D T +VWS+ T Sbjct: 125 NWENNWALEQ-----TFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTL 179 Query: 246 LDGHQRWV--WDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGH 291 G +R V D D Y++TAS D +++WD T+ V GH Sbjct: 180 TTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGH 227 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 44/227 (19%), Positives = 95/227 (41%), Gaps = 12/227 (5%) Query: 78 VTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGELISCDR 136 V + F W++ S+D I+V++ + +++ H + + +HP + ++S Sbjct: 58 VRAGKFIARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSD 117 Query: 137 DGNIRIWDLGENQCTHQLTPEDDTSLQSLSM-ASDGSMLAAANTKGNCYVWEMPNHTDAS 195 D +++W+ N Q + + ++ D S A+ VW + T Sbjct: 118 DLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQST--P 175 Query: 196 HLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLET---TLDGHQRW 252 + T Y+ L D ++ T S D T ++W D++ ++ TL+GH Sbjct: 176 NFTLTTGQERGVNYVDYYPLP-DKPYMITASDDLTIKIW----DYQTKSCVATLEGHMSN 230 Query: 253 VWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVA 299 V F +++ S D +++W+ ST ++ + + + C+A Sbjct: 231 VSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIA 277 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 47/248 (18%), Positives = 104/248 (41%), Gaps = 14/248 (5%) Query: 10 YDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVA 69 Y + W T V R+IQ +++ V + K + G + R+ V Sbjct: 33 YSGRVELWNYETQVEVRSIQVTETPVRAGKFIARKNWI-IVGSDDFRIRVFNYNTGEKVV 91 Query: 70 SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSP-SIPRNYK-HNAPVNEVVIHP- 126 FE H + S++ ++++ S+D T+K+W+ + ++ + ++ H V V +P Sbjct: 92 DFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPK 151 Query: 127 NQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSM--ASDGSMLAAANTKGNCY 184 + S D +++W LG++ LT + + + D + A+ Sbjct: 152 DPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIK 211 Query: 185 VWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLET 244 +W+ + + L+ H + ++ + + + + S D T ++W+ +K+E Sbjct: 212 IWDYQTKSCVATLE------GHMSNVSFAVFHPTLPIIISGSEDGTLKIWN-SSTYKVEK 264 Query: 245 TLD-GHQR 251 TL+ G +R Sbjct: 265 TLNVGLER 272 Score = 42.0 bits (97), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 33/160 (20%), Positives = 69/160 (43%), Gaps = 12/160 (7%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTI----QHSDSQVNRLEITNDKKLLATAGHQNVRLYDI 60 S D T++ W + T+ + + V+ + + ++ + ++++D Sbjct: 156 FASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDY 215 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVN 120 +T + VA+ EGH NV+ F +++ SEDGT+K+W+ + + + N + Sbjct: 216 QTKSC--VATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTL--NVGLE 271 Query: 121 E---VVIHP-NQGELISCDRDGNIRIWDLGENQCTHQLTP 156 + HP + I+ D + LG ++ T L P Sbjct: 272 RSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSLDP 311 >3MKQ-A nrPDB Length = 814 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 46/228 (20%), Positives = 89/228 (39%), Gaps = 14/228 (6%) Query: 70 SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQ 128 +F V + F W++T+ G +++W+ + R+ + PV + Sbjct: 8 TFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKFIARK 67 Query: 129 GELISCDRDGNIRIWDL--GENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVW 186 +I D IR+++ GE + P+ ++S+++ + + + +W Sbjct: 68 NWIIVGSDDFRIRVFNYNTGEKVVDFEAHPD---YIRSIAVHPTKPYVLSGSDDLTVKLW 124 Query: 187 EMPNHTDASHLKPVTKFRAHSTYITRILLS-SDVKHLATCSADHTARVWSIDDDFKLETT 245 N+ F H ++ + + D A+ D T +VWS+ T Sbjct: 125 NWENNWALEQ-----TFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTL 179 Query: 246 LDGHQRWV--WDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGH 291 G +R V D D Y++TAS D +++WD T+ V GH Sbjct: 180 TTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGH 227 Score = 45.8 bits (107), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 44/227 (19%), Positives = 95/227 (41%), Gaps = 12/227 (5%) Query: 78 VTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGELISCDR 136 V + F W++ S+D I+V++ + +++ H + + +HP + ++S Sbjct: 58 VRAGKFIARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSD 117 Query: 137 DGNIRIWDLGENQCTHQLTPEDDTSLQSLSM-ASDGSMLAAANTKGNCYVWEMPNHTDAS 195 D +++W+ N Q + + ++ D S A+ VW + T Sbjct: 118 DLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQST--P 175 Query: 196 HLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLET---TLDGHQRW 252 + T Y+ L D ++ T S D T ++W D++ ++ TL+GH Sbjct: 176 NFTLTTGQERGVNYVDYYPLP-DKPYMITASDDLTIKIW----DYQTKSCVATLEGHMSN 230 Query: 253 VWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVA 299 V F +++ S D +++W+ ST ++ + + + C+A Sbjct: 231 VSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIA 277 Score = 41.6 bits (96), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 31/119 (26%), Positives = 56/119 (47%), Gaps = 9/119 (7%) Query: 43 DKKLLATAGHQ-NVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKV 101 DK + TA ++++D +T + VA+ EGH NV+ F +++ SEDGT+K+ Sbjct: 197 DKPYMITASDDLTIKIWDYQTKSC--VATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKI 254 Query: 102 WDVRSPSIPRNYKHNAPVNE---VVIHP-NQGELISCDRDGNIRIWDLGENQCTHQLTP 156 W+ + + + N + + HP + I+ D + LG ++ T L P Sbjct: 255 WNSSTYKVEKTL--NVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSLDP 311 >4N14-A nrPDB Length = 314 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 39/189 (20%), Positives = 72/189 (38%), Gaps = 23/189 (12%) Query: 58 YDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRN----- 112 +D+R + VA+ GH V + + D R + + D + VW PS P Sbjct: 130 HDVRVAEHH-VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW----PSAPGEGGWVP 184 Query: 113 ----YKHNAPVNEVVIHPNQGELISCD---RDGNIRIWDLGENQCTHQLTPEDDTSLQSL 165 +H V V P Q +++ D +IRIW++ C + Sbjct: 185 LQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILW 244 Query: 166 SMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATC 225 S + + +W+ P + V + + H++ + + +S D +A+ Sbjct: 245 SPHYKELISGHGFAQNQLVIWKYPT------MAKVAELKGHTSRVLSLTMSPDGATVASA 298 Query: 226 SADHTARVW 234 +AD T R+W Sbjct: 299 AADETLRLW 307 Score = 37.0 bits (84), Expect = 0.010, Method: Compositional matrix adjust. Identities = 21/92 (22%), Positives = 40/92 (43%) Query: 11 DHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVAS 70 D IR W +G C + + L + K+L++ G +L + VA Sbjct: 216 DRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAE 275 Query: 71 FEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW 102 +GH V S++ D + +++ D T+++W Sbjct: 276 LKGHTSRVLSLTMSPDGATVASAAADETLRLW 307 Score = 32.3 bits (72), Expect = 0.29, Method: Compositional matrix adjust. Identities = 58/284 (20%), Positives = 106/284 (37%), Gaps = 22/284 (7%) Query: 24 CSRTIQHSDSQVNRLEITNDKKL----------LATAGHQNVRLYDIRTTNPNPVASFEG 73 C D ++ EI ND L LA A +V L+ + + + E Sbjct: 2 CRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQ 61 Query: 74 HRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQGELI 132 ++SV++ ++ ++ + +++WDV+ RN H+A V + N L Sbjct: 62 PGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILS 119 Query: 133 SCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHT 192 S R G+I D+ + + L A DG LA+ VW P+ Sbjct: 120 SGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW--PSAP 177 Query: 193 DASHLKPVTKFRAHSTYITRIL---LSSDVKHLATCSADHTARVWSIDDDFKLETTLDGH 249 P+ F H + + S+V ++D R+W++ L + +D H Sbjct: 178 GEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACL-SAVDAH 236 Query: 250 QRWVWDCAFSADSAYLVTAS--SDHYVRLWDLSTREIVRQYGGH 291 + V +S L++ + + + +W T V + GH Sbjct: 237 SQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGH 279 Score = 28.5 bits (62), Expect = 3.7, Method: Compositional matrix adjust. Identities = 38/199 (19%), Positives = 74/199 (37%), Gaps = 26/199 (13%) Query: 106 SPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTS-LQS 164 +P I +Y N ++ + G +++ D ++ +W L E + S Sbjct: 15 APEIRNDYYLN------LVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISS 68 Query: 165 LSMASDGSMLAAANTKGNCYVWEMPNHTD----ASHLKPVTKFRAHSTYITRILLSSDVK 220 ++ +G+ LA + +W++ SH V +S ++ S + Sbjct: 69 VAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIH 128 Query: 221 HLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLS 280 H A+H TL GH + V ++ D +L + +D+ V +W + Sbjct: 129 HHDVRVAEHHV------------ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSA 176 Query: 281 TRE---IVRQYGGHHKGAV 296 E + Q H+GAV Sbjct: 177 PGEGGWVPLQTFTQHQGAV 195 >4A11-B nrPDB Length = 408 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 55/242 (22%), Positives = 92/242 (38%), Gaps = 37/242 (15%) Query: 74 HRGNVTSVSFQQ-DNRWMVTSSEDGTIKVWDVRSP------------SIPRNYK--HNAP 118 H G + ++ + + R+M++ DG I ++D+ + SI R++ H Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 119 VNEVVIHP-NQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAA 177 V V +P + G S D +++WD Q E+ +S S L A Sbjct: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAV 161 Query: 178 NTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKH-LATCSADHTARVWSI 236 T+G SH+ + H I + S + LAT SAD ++W + Sbjct: 162 GTRGPKVQLCDLKSGSCSHI-----LQGHRQEILAVSWSPRYDYILATASADSRVKLWDV 216 Query: 237 DDDFKLETTLD---------------GHQRWVWDCAFSADSAYLVTASSDHYVRLWDLST 281 TLD H V F++D +L+T +D+ +RLW+ S Sbjct: 217 RRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSN 276 Query: 282 RE 283 E Sbjct: 277 GE 278 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 59/288 (20%), Positives = 113/288 (39%), Gaps = 38/288 (13%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNR-LEITNDKKLLATAGHQN--VRLYDI 60 + S+ +D T++ W+ T + ++ + + + K L G + V+L D+ Sbjct: 114 MFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDL 173 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMV-TSSEDGTIKVWDVRSPSIPRNYKHNAPV 119 ++ + + + +GHR + +VS+ +++ T+S D +K+WDVR S Sbjct: 174 KSGSCSHI--LQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRAS----------- 220 Query: 120 NEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANT 179 G LI+ D+ + +Q + + L SDG L T Sbjct: 221 ---------GCLITLDQHNGKK------SQAVESANTAHNGKVNGLCFTSDGLHLLTVGT 265 Query: 180 KGNCYVWEMPN--HTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSID 237 +W N +T ++ K + + SS+ + S T V+++ Sbjct: 266 DNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGS---TIAVYTVY 322 Query: 238 DDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIV 285 ++ T L GH + V C F ++ L + S D + W S E V Sbjct: 323 SGEQI-TMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPV 369 Score = 35.8 bits (81), Expect = 0.026, Method: Compositional matrix adjust. Identities = 49/251 (19%), Positives = 93/251 (37%), Gaps = 30/251 (11%) Query: 74 HRGNVTSVS-FQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGE-- 130 HR +V +V + D +SS D T+KVWD + + V + P + Sbjct: 98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHC 157 Query: 131 LISCDRDG-NIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWE-- 187 L++ G +++ DL C+H L L +LA A+ +W+ Sbjct: 158 LVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR 217 Query: 188 --------MPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDD 239 + H + AH+ + + +SD HL T D+ R+W+ + Sbjct: 218 RASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNG 277 Query: 240 FKLETTLDGHQ----------RWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYG 289 E TL + ++ C S++ ++ S+ + ++ + + E + Sbjct: 278 ---ENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGST---IAVYTVYSGEQITMLK 331 Query: 290 GHHKGAVCVAL 300 GH+K C Sbjct: 332 GHYKTVDCCVF 342 >5WLC-LJ nrPDB Length = 513 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 44/156 (28%), Positives = 71/156 (45%), Gaps = 11/156 (7%) Query: 125 HPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCY 184 HP+ + S R ++I+ Q + D + S S SDG +L A + G Sbjct: 51 HPHDFAVTSSTR---VQIFSSRTRQVIKTFSRFKDV-VYSASFRSDGKLLCAGDATGLVS 106 Query: 185 VWEMPN-HTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLE 243 V++ N T + T H T++T+ + D K LAT S D R+W I + ++ + Sbjct: 107 VYDSYNPRTILLSINAST----HPTHVTK-FHTQDNKILATASDDRVTRLWDISNAYEPQ 161 Query: 244 TTLDGHQRWVWDCAFSADSAYLV-TASSDHYVRLWD 278 L G +V +F + +LV T S D +RL+D Sbjct: 162 LELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYD 197 Score = 29.3 bits (64), Expect = 2.1, Method: Compositional matrix adjust. Identities = 24/107 (22%), Positives = 49/107 (45%), Gaps = 5/107 (4%) Query: 85 QDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAP--VNEVVIHPNQGELISC-DRDGNIR 141 QDN+ + T+S+D ++WD+ + P+ A V + P L++ DG IR Sbjct: 135 QDNKILATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIR 194 Query: 142 IWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEM 188 ++D + T + D ++++ S +++ N VW++ Sbjct: 195 LYDTRSSGSTPIYSLNHDQPVENVIAVSPTQIVSCGG--NNFKVWDL 239 >5LCW-Q nrPDB Length = 374 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 39/189 (20%), Positives = 72/189 (38%), Gaps = 23/189 (12%) Query: 58 YDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRN----- 112 +D+R + VA+ GH V + + D R + + D + VW PS P Sbjct: 168 HDVRVAEHH-VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW----PSAPGEGGWVP 222 Query: 113 ----YKHNAPVNEVVIHPNQGELISCD---RDGNIRIWDLGENQCTHQLTPEDDTSLQSL 165 +H V V P Q +++ D +IRIW++ C + Sbjct: 223 LQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILW 282 Query: 166 SMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATC 225 S + + +W+ P + V + + H++ + + +S D +A+ Sbjct: 283 SPHYKELISGHGFAQNQLVIWKYPT------MAKVAELKGHTSRVLSLTMSPDGATVASA 336 Query: 226 SADHTARVW 234 +AD T R+W Sbjct: 337 AADETLRLW 345 Score = 36.2 bits (82), Expect = 0.017, Method: Compositional matrix adjust. Identities = 24/103 (23%), Positives = 45/103 (43%), Gaps = 2/103 (1%) Query: 2 SVILVSAG--YDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYD 59 S +L + G D IR W +G C + + L + K+L++ G +L Sbjct: 243 SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVI 302 Query: 60 IRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW 102 + VA +GH V S++ D + +++ D T+++W Sbjct: 303 WKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 345 Score = 32.0 bits (71), Expect = 0.34, Method: Compositional matrix adjust. Identities = 63/306 (20%), Positives = 118/306 (38%), Gaps = 29/306 (9%) Query: 9 GYDHTIRFW---EALTGVCSRTIQHSDSQVNRL----EITNDKKL----------LATAG 51 GY + ++ +A G +T ++ S +R+ EI ND L LA A Sbjct: 18 GYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVAL 77 Query: 52 HQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPR 111 +V L+ + + + E ++SV++ ++ ++ + +++WDV+ R Sbjct: 78 DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLR 137 Query: 112 NY-KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASD 170 N H+A V + N L S R G+I D+ + + L A D Sbjct: 138 NMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPD 195 Query: 171 GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRIL---LSSDVKHLATCSA 227 G LA+ VW P+ P+ F H + + S+V ++ Sbjct: 196 GRHLASGGNDNLVNVW--PSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTS 253 Query: 228 DHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTAS--SDHYVRLWDLSTREIV 285 D R+W++ L + +D H + V +S L++ + + + +W T V Sbjct: 254 DRHIRIWNVCSGACL-SAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKV 311 Query: 286 RQYGGH 291 + GH Sbjct: 312 AELKGH 317 Score = 28.5 bits (62), Expect = 4.0, Method: Compositional matrix adjust. Identities = 34/176 (19%), Positives = 65/176 (36%), Gaps = 20/176 (11%) Query: 129 GELISCDRDGNIRIWDLGENQCTHQLTPEDDTS-LQSLSMASDGSMLAAANTKGNCYVWE 187 G +++ D ++ +W L E + S++ +G+ LA + +W+ Sbjct: 70 GNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWD 129 Query: 188 MPNHTD----ASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLE 243 + SH V +S ++ S + H A+H Sbjct: 130 VQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHV------------ 177 Query: 244 TTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTRE---IVRQYGGHHKGAV 296 TL GH + V ++ D +L + +D+ V +W + E + Q H+GAV Sbjct: 178 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAV 233 >6CHG-A nrPDB Length = 312 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 48/278 (17%), Positives = 121/278 (43%), Gaps = 21/278 (7%) Query: 39 EITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGT 98 +I+ D +L+A + ++ +Y+I ++ + + H+ + + + D++ + + SED T Sbjct: 20 QISPDGELIAICQNTDMLVYEISSSKMMKLTT--THKECINCLCWSPDSKCIASGSEDFT 77 Query: 99 IKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPED 158 +++ + I R H APV + + L S D +I+ W + ++ Sbjct: 78 VEITHIIYGRIRRLMGHTAPVISICYNNKGNILCSSSMDESIKEWHVLSGTALKTMSAHS 137 Query: 159 DTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASH-LKPVTKFR-----AHSTYITR 212 D + D S+L++ + G +++ T++ H LK +T + I+ Sbjct: 138 DAVVSIDIPKFDSSILSSGSYDGLIRIFD----TESGHCLKTLTYDKDWIAEDGVVPIST 193 Query: 213 ILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQ----RWVWDCAFS-----ADSA 263 + S + K L S D+ ++W + T L HQ + ++C Sbjct: 194 VKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLKYNCGLELIYPQGKDP 253 Query: 264 YLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 +++ + + +W++ ++ +V++ H+ + ++++ Sbjct: 254 LVISGNDSGSMCVWNVYSKNLVQKIDEKHRNSPLISIS 291 Score = 44.3 bits (103), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 42/208 (20%), Positives = 100/208 (48%), Gaps = 28/208 (13%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQ-HSDSQVNRLEITNDKKLLATAGHQN-VRLYDIR 61 IL S+ D +I+ W L+G +T+ HSD+ V+ D +L++ + +R++D Sbjct: 109 ILCSSSMDESIKEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTE 168 Query: 62 TTNPNPVASF------EGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-- 113 + + ++ E +++V F ++ ++++ S D +K+W+ ++ R + Sbjct: 169 SGHCLKTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLW 228 Query: 114 ---------KHNAPVNEVVIHPNQGE---LISCDRDGNIRIWDLGENQCTHQLTPE-DDT 160 K+N + +I+P QG+ +IS + G++ +W++ ++ + ++ Sbjct: 229 PHQETKAKLKYNCGLE--LIYP-QGKDPLVISGNDSGSMCVWNVYSKNLVQKIDEKHRNS 285 Query: 161 SLQSLSMASDGSMLAAANTKGNCYVWEM 188 L S+S + D +A + G C ++ + Sbjct: 286 PLISISASYDK--VATLSLNGECNLFRV 311 >4GGA-A nrPDB Length = 420 Score = 44.7 bits (104), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 39/189 (20%), Positives = 72/189 (38%), Gaps = 23/189 (12%) Query: 58 YDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRN----- 112 +D+R + VA+ GH V + + D R + + D + VW PS P Sbjct: 214 HDVRVAEHH-VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW----PSAPGEGGWVP 268 Query: 113 ----YKHNAPVNEVVIHPNQGELISCD---RDGNIRIWDLGENQCTHQLTPEDDTSLQSL 165 +H V V P Q +++ D +IRIW++ C + Sbjct: 269 LQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILW 328 Query: 166 SMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATC 225 S + + +W+ P + V + + H++ + + +S D +A+ Sbjct: 329 SPHYKELISGHGFAQNQLVIWKYPT------MAKVAELKGHTSRVLSLTMSPDGATVASA 382 Query: 226 SADHTARVW 234 +AD T R+W Sbjct: 383 AADETLRLW 391 Score = 35.8 bits (81), Expect = 0.022, Method: Compositional matrix adjust. Identities = 24/103 (23%), Positives = 45/103 (43%), Gaps = 2/103 (1%) Query: 2 SVILVSAG--YDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYD 59 S +L + G D IR W +G C + + L + K+L++ G +L Sbjct: 289 SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVI 348 Query: 60 IRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW 102 + VA +GH V S++ D + +++ D T+++W Sbjct: 349 WKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 391 Score = 31.2 bits (69), Expect = 0.50, Method: Compositional matrix adjust. Identities = 63/306 (20%), Positives = 118/306 (38%), Gaps = 29/306 (9%) Query: 9 GYDHTIRFW---EALTGVCSRTIQHSDSQVNRL----EITNDKKL----------LATAG 51 GY + ++ +A G +T ++ S +R+ EI ND L LA A Sbjct: 64 GYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVAL 123 Query: 52 HQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPR 111 +V L+ + + + E ++SV++ ++ ++ + +++WDV+ R Sbjct: 124 DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLR 183 Query: 112 NY-KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASD 170 N H+A V + N L S R G+I D+ + + L A D Sbjct: 184 NMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPD 241 Query: 171 GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRIL---LSSDVKHLATCSA 227 G LA+ VW P+ P+ F H + + S+V ++ Sbjct: 242 GRHLASGGNDNLVNVW--PSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTS 299 Query: 228 DHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTAS--SDHYVRLWDLSTREIV 285 D R+W++ L + +D H + V +S L++ + + + +W T V Sbjct: 300 DRHIRIWNVCSGACL-SAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKV 357 Query: 286 RQYGGH 291 + GH Sbjct: 358 AELKGH 363 Score = 28.5 bits (62), Expect = 4.0, Method: Compositional matrix adjust. Identities = 34/176 (19%), Positives = 65/176 (36%), Gaps = 20/176 (11%) Query: 129 GELISCDRDGNIRIWDLGENQCTHQLTPEDDTS-LQSLSMASDGSMLAAANTKGNCYVWE 187 G +++ D ++ +W L E + S++ +G+ LA + +W+ Sbjct: 116 GNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWD 175 Query: 188 MPNHTD----ASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLE 243 + SH V +S ++ S + H A+H Sbjct: 176 VQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHV------------ 223 Query: 244 TTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTRE---IVRQYGGHHKGAV 296 TL GH + V ++ D +L + +D+ V +W + E + Q H+GAV Sbjct: 224 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAV 279 >5MWJ-A nrPDB Length = 337 Score = 44.7 bits (104), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 44/185 (23%), Positives = 81/185 (43%), Gaps = 30/185 (16%) Query: 74 HRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEV----------- 122 H V +V+ R + T + G +KVWD+ P + +PV+++ Sbjct: 50 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDISHPG------NKSPVSQLDCLNRDNYIRS 102 Query: 123 -VIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTS---LQSLSMASDGSMLAAAN 178 + P+ LI + IWDL T ++ E +S +L+++ D + + Sbjct: 103 CKLLPDGCTLIVGGEASTLSIWDLAAP--TPRIKAELTSSAPACYALAISPDSKVCFSCC 160 Query: 179 TKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDD 238 + GN VW++ N T V +F+ H+ + I +S+D L T D+T R W + + Sbjct: 161 SDGNIAVWDLHNQT------LVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLRE 214 Query: 239 DFKLE 243 +L+ Sbjct: 215 GRQLQ 219 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 32/126 (25%), Positives = 54/126 (42%), Gaps = 6/126 (4%) Query: 180 KGNCYVWEMPNHTDASHLKPVTKFRA--HSTYITRILLSSDVKHLATCSADHTARVWSID 237 KG VW++ + + S PV++ YI L D L T +W + Sbjct: 71 KGCVKVWDISHPGNKS---PVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLA 127 Query: 238 DDF-KLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAV 296 +++ L + A S DS + SD + +WDL + +VRQ+ GH GA Sbjct: 128 APTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGAS 187 Query: 297 CVALND 302 C+ +++ Sbjct: 188 CIDISN 193 Score = 35.4 bits (80), Expect = 0.027, Method: Compositional matrix adjust. Identities = 47/235 (20%), Positives = 84/235 (35%), Gaps = 14/235 (5%) Query: 5 LVSAGYDHTIRFWE--ALTGVCSRTIQHSDSQVNRLEITNDKKL-LATAGHQNVRLYDIR 61 L+ G T+ W+ A T + S L I+ D K+ + N+ ++D+ Sbjct: 112 LIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLH 171 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNE 121 N V F+GH + + D + T D T++ WD+R + + + + Sbjct: 172 --NQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFS 229 Query: 122 VVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKG 181 + P L N+ + + + +QL + L SL A G + Sbjct: 230 LGYCPTGEWLAVGMESSNVEVLHVNKPD-KYQLHLHESCVL-SLKFAYCGKWFVSTGKDN 287 Query: 182 NCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI 236 W P K S+ + +S D K++ T S D A V+ + Sbjct: 288 LLNAWRTPYGASIFQSK-------ESSSVLSCDISVDDKYIVTGSGDKKATVYEV 335 Score = 29.6 bits (65), Expect = 1.7, Method: Compositional matrix adjust. Identities = 30/143 (20%), Positives = 51/143 (35%), Gaps = 4/143 (2%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQN-VRLYDI 60 S + S D I W+ R Q + ++I+ND L T G N VR +D+ Sbjct: 153 SKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDL 212 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVN 120 R F + S+ + W+ E ++V V P + + H + V Sbjct: 213 REGRQLQQHDFTSQ---IFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVL 269 Query: 121 EVVIHPNQGELISCDRDGNIRIW 143 + +S +D + W Sbjct: 270 SLKFAYCGKWFVSTGKDNLLNAW 292 >5WLC-LU nrPDB Length = 489 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 37/160 (23%), Positives = 67/160 (41%), Gaps = 21/160 (13%) Query: 127 NQGE---LISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMAS------DGSMLAAA 177 NQ E L S D +I ++DL N T ++ +Q++ + + A Sbjct: 228 NQNETDILASTGSDNSIVLYDLRTNSPTQKI-------VQTMRTNAICWNPMEAFNFVTA 280 Query: 178 NTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSID 237 N N Y ++M N + + + F+ H + + + S + T S D + R++ + Sbjct: 281 NEDHNAYYYDMRNLS-----RSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTN 335 Query: 238 DDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 E + V+ +S DS Y+++ S D VRLW Sbjct: 336 HGHSREIYHTKRMQHVFQVKYSMDSKYIISGSDDGNVRLW 375 Score = 30.0 bits (66), Expect = 1.3, Method: Compositional matrix adjust. Identities = 46/237 (19%), Positives = 100/237 (42%), Gaps = 40/237 (16%) Query: 73 GHRGNVTSVS--FQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEV-VIHP-- 126 GHR V +++ + N+ + T S DG IK W++ + ++K H V + V P Sbjct: 65 GHRDGVYAIAKNYGSLNK-LATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPRF 123 Query: 127 --------NQGELISCDRDGNIRIWDLGENQCTHQLTPEDD---------------TSLQ 163 +Q ++SC D +++W + + +++ + ++D ++ Q Sbjct: 124 HDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAFQ 183 Query: 164 SLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLS-SDVKHL 222 + + S A K ++W D + LKPV+ + IT + + ++ L Sbjct: 184 GIDSHRENSTFATGGAK--IHLW------DVNRLKPVSDLSWGADNITSLKFNQNETDIL 235 Query: 223 ATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDL 279 A+ +D++ ++ + + + + R C ++ VTA+ DH +D+ Sbjct: 236 ASTGSDNSIVLYDLRTNSPTQKIVQT-MRTNAICWNPMEAFNFVTANEDHNAYYYDM 291 Score = 28.5 bits (62), Expect = 3.6, Method: Compositional matrix adjust. Identities = 15/46 (32%), Positives = 25/46 (54%), Gaps = 1/46 (2%) Query: 248 GHQRWVWDCAFSADSA-YLVTASSDHYVRLWDLSTREIVRQYGGHH 292 GH+ V+ A + S L T S+D ++ W++STRE + H+ Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHY 110 >5FA5-B nrPDB Length = 367 Score = 43.9 bits (102), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 35/127 (27%), Positives = 59/127 (46%), Gaps = 5/127 (3%) Query: 22 GVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASF--EGHRGNVT 79 G CS +Q +++ V L ++ +L + V L+++ V+ F H V+ Sbjct: 96 GFCSAGVQ-TEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVS 154 Query: 80 SVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGE-LISCDRD 137 +VS V+ S+D IKVWD+ + +Y+ H A V V P++ +SC D Sbjct: 155 TVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSED 214 Query: 138 GNIRIWD 144 I +WD Sbjct: 215 NRILLWD 221 Score = 29.3 bits (64), Expect = 2.5, Method: Compositional matrix adjust. Identities = 11/34 (32%), Positives = 19/34 (55%) Query: 266 VTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVA 299 V+ S D +++WDL+ + ++ Y H CVA Sbjct: 166 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVA 199 >6E29-D nrPDB Length = 345 Score = 43.9 bits (102), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 54/257 (21%), Positives = 98/257 (38%), Gaps = 42/257 (16%) Query: 70 SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHP-NQ 128 GH N+TS+S+ + R+++++ + + +WD++ R + APV +HP N Sbjct: 62 KLRGHSKNITSLSWSRCGRYLLSACQGWKVILWDLQDGKRYREVRFRAPVYGAELHPWNH 121 Query: 129 GELISCDRDGNIRIWDLGENQCTHQLTP--------EDDTSLQSLSMASD---------- 170 + + + + D+ E + P E D +L+ D Sbjct: 122 HQFAAALFEDQPMLVDITEPVEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVY 181 Query: 171 ---GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSA 227 G L A TKG N DA + + + S IT + L+ + L + Sbjct: 182 TASGDHLLAGTTKGRL------NIIDARTREIIYSEKIASGIITTLRLTESGRELLVNAQ 235 Query: 228 DHTARVWSIDD-----------DFKLETTL-DGHQRWVWD-CAFSADSAYLVTAS-SDHY 273 D R + + + LE D R W+ AFSA Y+ ++ ++H Sbjct: 236 DRIIRTFIVPNLSAADLDPDTIQLPLEHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHE 295 Query: 274 VRLWDLSTREIVRQYGG 290 + +W+ +VR G Sbjct: 296 LYIWERGHGSLVRMLEG 312 Score = 30.0 bits (66), Expect = 1.3, Method: Compositional matrix adjust. Identities = 16/75 (21%), Positives = 36/75 (48%), Gaps = 1/75 (1%) Query: 76 GNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGELISC 134 G+ T V F + ++ + DGT+ +WD+ + + R + H+ + + L+S Sbjct: 26 GHSTCVRFNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWSRCGRYLLSA 85 Query: 135 DRDGNIRIWDLGENQ 149 + + +WDL + + Sbjct: 86 CQGWKVILWDLQDGK 100 Score = 27.7 bits (60), Expect = 5.7, Method: Compositional matrix adjust. Identities = 12/36 (33%), Positives = 18/36 (50%) Query: 258 FSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHK 293 F+ +L + D V +WDL T + R+ GH K Sbjct: 33 FNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSK 68 >6EM1-m nrPDB Length = 807 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 25/99 (25%), Positives = 48/99 (48%), Gaps = 12/99 (12%) Query: 8 AGYDHTIR--FWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNP 65 GY +IR F +L + ++ N+L I + + +++R + IR + Sbjct: 378 PGYGESIRERFERSLDLYLAPRVRK-----NKLNIDPNSLIPELPSPKDLRPFPIRCS-- 430 Query: 66 NPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDV 104 + GH+G V ++S W+ T S+DGT++VW++ Sbjct: 431 ---TIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEI 466 Score = 26.9 bits (58), Expect = 9.6, Method: Compositional matrix adjust. Identities = 15/44 (34%), Positives = 22/44 (50%), Gaps = 1/44 (2%) Query: 244 TTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWD-LSTREIVR 286 T GH+ V + +L T S D VR+W+ L+ RE+ R Sbjct: 431 TIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYR 474 >6CB1-s nrPDB Length = 569 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 25/99 (25%), Positives = 48/99 (48%), Gaps = 12/99 (12%) Query: 8 AGYDHTIR--FWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNP 65 GY +IR F +L + ++ N+L I + + +++R + IR + Sbjct: 140 PGYGESIRERFERSLDLYLAPRVRK-----NKLNIDPNSLIPELPSPKDLRPFPIRCS-- 192 Query: 66 NPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDV 104 + GH+G V ++S W+ T S+DGT++VW++ Sbjct: 193 ---TIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEI 228 Score = 27.7 bits (60), Expect = 6.8, Method: Compositional matrix adjust. Identities = 26/112 (23%), Positives = 50/112 (44%), Gaps = 15/112 (13%) Query: 46 LLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWD-- 103 L+A++ + V +D+ + P + H V SV+F + ++++DGTI V+ Sbjct: 457 LIASSFDKRVLWHDLDLAS-TPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHAT 515 Query: 104 -----VRSPSIPRNYK-------HNAPVNEVVIHPNQGELISCDRDGNIRIW 143 +++P I K ++ V + + HP + L S D R+W Sbjct: 516 VYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 567 Score = 27.3 bits (59), Expect = 9.4, Method: Compositional matrix adjust. Identities = 31/176 (17%), Positives = 73/176 (41%), Gaps = 11/176 (6%) Query: 69 ASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAP-VNEVVIHPN 127 + F+ +G + F + S+ ++++D+ + + A ++++ IHP Sbjct: 395 SPFKKSKGIIMDAKFHPFKPQLFVCSQR-YVRIYDLSQQILVKKLLPGARWLSKIDIHPR 453 Query: 128 QGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWE 187 LI+ D + DL ++ + +++S++ + ++A G +V+ Sbjct: 454 GDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFH 513 Query: 188 MPNHTDA---SHLKPVTKFRAHSTYITRILLSSDVKH-----LATCSADHTARVWS 235 + D + P+ K H I + + + H L + AD+TAR+W+ Sbjct: 514 ATVYDDMMKNPMIVPLKKLTGHKV-INSLGVLDAIWHPREAWLFSAGADNTARLWT 568 >6C0F-s nrPDB Length = 807 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 25/98 (25%), Positives = 48/98 (48%), Gaps = 12/98 (12%) Query: 9 GYDHTIR--FWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPN 66 GY +IR F +L + ++ N+L I + + +++R + IR + Sbjct: 379 GYGESIRERFERSLDLYLAPRVRK-----NKLNIDPNSLIPELPSPKDLRPFPIRCS--- 430 Query: 67 PVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDV 104 + GH+G V ++S W+ T S+DGT++VW++ Sbjct: 431 --TIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEI 466 Score = 27.3 bits (59), Expect = 8.7, Method: Compositional matrix adjust. Identities = 15/44 (34%), Positives = 22/44 (50%), Gaps = 1/44 (2%) Query: 244 TTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWD-LSTREIVR 286 T GH+ V + +L T S D VR+W+ L+ RE+ R Sbjct: 431 TIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYR 474 >5G04-R nrPDB Length = 499 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 37/179 (20%), Positives = 67/179 (37%), Gaps = 22/179 (12%) Query: 68 VASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRN---------YKHNAP 118 VA+ GH V + + D R + + D + VW PS P +H Sbjct: 302 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW----PSAPGEGGWVPLQTFTQHQGA 357 Query: 119 VNEVVIHPNQGELISCD---RDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLA 175 V V P Q +++ D +IRIW++ C + S + Sbjct: 358 VKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISG 417 Query: 176 AANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVW 234 + +W+ P + V + + H++ + + +S D +A+ +AD T R+W Sbjct: 418 HGFAQNQLVIWKYPT------MAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 Score = 35.4 bits (80), Expect = 0.028, Method: Compositional matrix adjust. Identities = 24/103 (23%), Positives = 45/103 (43%), Gaps = 2/103 (1%) Query: 2 SVILVSAG--YDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYD 59 S +L + G D IR W +G C + + L + K+L++ G +L Sbjct: 368 SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVI 427 Query: 60 IRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW 102 + VA +GH V S++ D + +++ D T+++W Sbjct: 428 WKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 Score = 29.6 bits (65), Expect = 1.6, Method: Compositional matrix adjust. Identities = 63/306 (20%), Positives = 118/306 (38%), Gaps = 29/306 (9%) Query: 9 GYDHTIRFW---EALTGVCSRTIQHSDSQVNRL----EITNDKKL----------LATAG 51 GY + ++ +A G +T ++ S +R+ EI ND L LA A Sbjct: 143 GYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVAL 202 Query: 52 HQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPR 111 +V L+ + + + E ++SV++ ++ ++ + +++WDV+ R Sbjct: 203 DNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLR 262 Query: 112 NY-KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASD 170 N H+A V + N L S R G+I D+ + + L A D Sbjct: 263 NMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPD 320 Query: 171 GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRIL---LSSDVKHLATCSA 227 G LA+ VW P+ P+ F H + + S+V ++ Sbjct: 321 GRHLASGGNDNLVNVW--PSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTS 378 Query: 228 DHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTAS--SDHYVRLWDLSTREIV 285 D R+W++ L + +D H + V +S L++ + + + +W T V Sbjct: 379 DRHIRIWNVCSGACL-SAVDAHSQ-VCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKV 436 Query: 286 RQYGGH 291 + GH Sbjct: 437 AELKGH 442 Score = 28.1 bits (61), Expect = 4.8, Method: Compositional matrix adjust. Identities = 34/176 (19%), Positives = 65/176 (36%), Gaps = 20/176 (11%) Query: 129 GELISCDRDGNIRIWDLGENQCTHQLTPEDDTS-LQSLSMASDGSMLAAANTKGNCYVWE 187 G +++ D ++ +W L E + S++ +G+ LA + +W+ Sbjct: 195 GNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWD 254 Query: 188 MPNHTD----ASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLE 243 + SH V +S ++ S + H A+H Sbjct: 255 VQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHV------------ 302 Query: 244 TTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTRE---IVRQYGGHHKGAV 296 TL GH + V ++ D +L + +D+ V +W + E + Q H+GAV Sbjct: 303 ATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAV 358 >5WYJ-BE nrPDB Length = 939 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 36/162 (22%), Positives = 70/162 (43%), Gaps = 9/162 (5%) Query: 76 GNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGELISC 134 G V SV+ Q + S +G+I +++++S + + YK H V + + +++SC Sbjct: 461 GFVKSVAMSQCGNFGFIGSSNGSITIYNMQSGILRKKYKLHKRAVTGISLDGMNRKMVSC 520 Query: 135 DRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDA 194 DG + +D ++ +L + D + ++ + A A + V DA Sbjct: 521 GLDGIVGFYDFNKSTLLGKL--KLDAPITAMVYHRSSDLFALALDDLSIVV------IDA 572 Query: 195 SHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI 236 + V + HS IT S + + + + S D T R W + Sbjct: 573 VTQRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTWDL 614 Score = 38.5 bits (88), Expect = 0.003, Method: Compositional matrix adjust. Identities = 25/119 (21%), Positives = 51/119 (42%), Gaps = 1/119 (0%) Query: 71 FEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGE 130 ++ H+ VT +S NR MV+ DG + +D ++ K +AP+ +V H + Sbjct: 498 YKLHKRAVTGISLDGMNRKMVSCGLDGIVGFYDFNKSTLLGKLKLDAPITAMVYHRSSDL 557 Query: 131 LISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMP 189 D +I + D + QL + + + + +G + +A+ W++P Sbjct: 558 FALALDDLSIVVIDAVTQRVVRQLWGHSN-RITAFDFSPEGRWIVSASLDSTIRTWDLP 615 Score = 36.6 bits (83), Expect = 0.014, Method: Compositional matrix adjust. Identities = 22/72 (30%), Positives = 33/72 (45%), Gaps = 1/72 (1%) Query: 73 GHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELI 132 GH +T+ F + RW+V++S D TI+ WD+ + + V PN L Sbjct: 583 GHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTGGCIDGIIVDNVATNVKFSPNGDLLA 642 Query: 133 SCDRDGN-IRIW 143 + GN I IW Sbjct: 643 TTHVTGNGICIW 654 Score = 28.9 bits (63), Expect = 2.5, Method: Compositional matrix adjust. Identities = 13/34 (38%), Positives = 19/34 (55%) Query: 248 GHQRWVWDCAFSADSAYLVTASSDHYVRLWDLST 281 GH + FS + ++V+AS D +R WDL T Sbjct: 583 GHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPT 616 >5A9Q-2 nrPDB Length = 326 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 35/163 (21%), Positives = 67/163 (41%), Gaps = 4/163 (2%) Query: 45 KLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSF-QQDNRWMVTSSEDGTIKVWD 103 K +A +RL+ + N EGH + + F ++ + + + S+D T ++W+ Sbjct: 94 KFCTSAADMKIRLFTSDLQDKNEYKVLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWN 153 Query: 104 VRSPSIPRNYKHNAPVNEVVIHPNQG-ELISCDRDGNIRIWDLGENQCTHQLTPEDDTSL 162 + H +P V HP + +L+ +++G IR +DL Q L E L Sbjct: 154 LEGVQTAHFVLH-SPGMSVCWHPEETFKLMVAEKNGTIRFYDLLAQQAILSLESE-QVPL 211 Query: 163 QSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRA 205 S + A + +W++ + + +PV RA Sbjct: 212 MSAHWCLKNTFKVGAVAGNDWLIWDITRSSYPQNKRPVHMDRA 254 Score = 28.9 bits (63), Expect = 2.5, Method: Compositional matrix adjust. Identities = 17/84 (20%), Positives = 39/84 (46%), Gaps = 3/84 (3%) Query: 203 FRAHSTYITRILL-SSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSAD 261 H+ +I ++ + + +A+ S DHT R+W+++ L H + C + Sbjct: 120 LEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFVL--HSPGMSVCWHPEE 177 Query: 262 SAYLVTASSDHYVRLWDLSTREIV 285 + L+ A + +R +DL ++ + Sbjct: 178 TFKLMVAEKNGTIRFYDLLAQQAI 201 >3EI3-B nrPDB Length = 383 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 25/76 (32%), Positives = 39/76 (51%), Gaps = 6/76 (7%) Query: 74 HRGNVTSVSFQQDNRW-MVTSSEDGTIKVWDVRSPSIPRNY----KHNAPVNEVVIHP-N 127 H+ VT F W M TSS D T+K+WD+R+ +Y H PVN +P + Sbjct: 203 HKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNAAYFNPTD 262 Query: 128 QGELISCDRDGNIRIW 143 +L++ D+ IR++ Sbjct: 263 STKLLTTDQRNEIRVY 278 >5N4A-A nrPDB Length = 771 Score = 42.0 bits (97), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 45/180 (25%), Positives = 75/180 (41%), Gaps = 23/180 (12%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTN 64 L +AG D +++ W + G+ T+ +DS V + D L NV + + + Sbjct: 119 LATAGEDGSVKIW-SRNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGSNVVIKSLSSNA 177 Query: 65 PNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVI 124 +++ H G V V + N ++T ED KVWD + ++ + PV V Sbjct: 178 KQN--AWKAHDGVVLKVDWSPINHLIITGGEDCKYKVWDSFGRLLFQSGLFDYPVTSVAW 235 Query: 125 HPNQGELIS---------CDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLA 175 P+ GEL + CDR G W ++ D S+ +LS +D + LA Sbjct: 236 APS-GELFAVGGFNTLQLCDRMG----W------AYSKIHLNDTGSIMTLSWTADSTQLA 284 Score = 35.8 bits (81), Expect = 0.023, Method: Compositional matrix adjust. Identities = 22/79 (27%), Positives = 37/79 (46%), Gaps = 1/79 (1%) Query: 70 SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQG 129 S EGH+G S+ + D + T+ EDG++K+W + ++PV +V + Sbjct: 99 SIEGHKGACISLRWSYDGTALATAGEDGSVKIWSRNGMLRSTLAQADSPVYSIVWAYDCD 158 Query: 130 ELISCDRDGNIRIWDLGEN 148 +L C N+ I L N Sbjct: 159 QLCYCT-GSNVVIKSLSSN 176 >4OWR-A nrPDB Length = 339 Score = 41.6 bits (96), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 26/101 (25%), Positives = 51/101 (50%), Gaps = 2/101 (1%) Query: 46 LLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVR 105 L+A + +VR ++++ + + + H G V V + D + T+S D T K+WD+ Sbjct: 28 LIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLS 87 Query: 106 SPSIPRNYKHNAPVNEV--VIHPNQGELISCDRDGNIRIWD 144 S + +H+APV + + PN +++ D ++ WD Sbjct: 88 SNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWD 128 Score = 31.2 bits (69), Expect = 0.55, Method: Compositional matrix adjust. Identities = 16/56 (28%), Positives = 28/56 (50%), Gaps = 1/56 (1%) Query: 232 RVWSIDDDFK-LETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVR 286 R W + D + + H V D +S D + + TAS D ++WDLS+ + ++ Sbjct: 38 RCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQ 93 Score = 27.7 bits (60), Expect = 6.0, Method: Compositional matrix adjust. Identities = 26/129 (20%), Positives = 54/129 (41%), Gaps = 7/129 (5%) Query: 153 QLTPEDDTSLQSLSMASD---GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTY 209 ++T D S+ LS + G+ L A + + WE+ D+ P + + H+ Sbjct: 4 EVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEV---QDSGQTIPKAQ-QMHTGP 59 Query: 210 ITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTAS 269 + + S D + T S D TA++W + + ++ + + + ++T S Sbjct: 60 VLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGS 119 Query: 270 SDHYVRLWD 278 D ++ WD Sbjct: 120 WDKTLKFWD 128 Score = 27.3 bits (59), Expect = 9.1, Method: Compositional matrix adjust. Identities = 15/64 (23%), Positives = 32/64 (50%), Gaps = 3/64 (4%) Query: 89 WMVTSSEDGTIKVWDVR--SPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDGNIRIWDL 145 +++ S ++ W+V+ +IP+ + H PV +V + ++ + D ++WDL Sbjct: 27 FLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDL 86 Query: 146 GENQ 149 NQ Sbjct: 87 SSNQ 90 >3W15-A nrPDB Length = 368 Score = 41.2 bits (95), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 52/208 (25%), Positives = 86/208 (41%), Gaps = 40/208 (19%) Query: 41 TNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRW-MVTSSEDGTI 99 +++ ++L G +RL+D T P+A F+ H V S ++ NR ++SS DG+I Sbjct: 73 SHENQVLVAQGDGTLRLFDT-TFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSI 131 Query: 100 KVWD-VRSPSI----PRNY---KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCT 151 K+W +R S+ PR K P+N +++ IS +R+ C Sbjct: 132 KIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRN------------CV 179 Query: 152 H--QLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVT-KFRAHST 208 + Q +P D + S S S S+ G N S L+ +T F + Sbjct: 180 YQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGK----NQNNFLVHSGLEALTCDFNKYRP 235 Query: 209 YITRILLSSDVKHLATCSADHTARVWSI 236 Y+ +AT D+ R+W I Sbjct: 236 YV-----------VATGGVDNAIRIWDI 252 Score = 29.3 bits (64), Expect = 2.3, Method: Compositional matrix adjust. Identities = 21/80 (26%), Positives = 39/80 (48%), Gaps = 3/80 (3%) Query: 46 LLATAGHQNVRLYDIRTTNPNPVASFEGHRG-NVTSVSFQQDNRWMV-TSSEDGTIKVWD 103 +L+ +G+ L+DIR + +F H G + F + ++V T D I++WD Sbjct: 192 VLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWD 251 Query: 104 VRSPSIPRNYKHNAP-VNEV 122 +R + HN+ +NE+ Sbjct: 252 IRMLNKNPGQLHNSSCINEI 271 >4L9O-A nrPDB Length = 349 Score = 40.8 bits (94), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 49/254 (19%), Positives = 97/254 (38%), Gaps = 22/254 (8%) Query: 44 KKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSS--EDGTIKV 101 ++L + + +++++I N V + GH G V V++ ++ +S DG + + Sbjct: 82 RRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVLI 141 Query: 102 WDVRSP---SIPRNYKHNAPVNEVVIHPNQ-GELISC-DRDGNIRIWDLGENQCTHQLTP 156 W + + + H A VN V P++ G ++ C DG I I + + + Sbjct: 142 WKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISIVEFKDGGALEPIVI 201 Query: 157 E------DDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYI 210 + + S +S+ + + +W + A F+ HS ++ Sbjct: 202 QGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDA--AKTFIEEEAFQGHSDWV 259 Query: 211 TRILLSSD---VKHLATCSADHTARVWSIDDDF----KLETTLDGHQRWVWDCAFSADSA 263 + S ++AT S D T +W+ D K T + W ++S Sbjct: 260 RDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVCWRASWSLSGN 319 Query: 264 YLVTASSDHYVRLW 277 L + D+ V LW Sbjct: 320 VLAISGGDNKVTLW 333 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 28/81 (34%), Positives = 42/81 (51%), Gaps = 3/81 (3%) Query: 200 VTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSID-DDFKLETTLDGHQRWVWDCAF 258 VT AH I +L + LATCS+D T +++ ID ++ +L TL GH+ VW A+ Sbjct: 62 VTIGNAHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAW 121 Query: 259 S--ADSAYLVTASSDHYVRLW 277 + L + S D V +W Sbjct: 122 AHPKFGVILASCSYDGKVLIW 142 Score = 30.4 bits (67), Expect = 1.0, Method: Compositional matrix adjust. Identities = 23/112 (20%), Positives = 43/112 (38%), Gaps = 10/112 (8%) Query: 1 MSVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEIT-----NDKKLLATAGHQNV 55 VIL S YD + W+ GV ++ +HS Q + ++ LL + + Sbjct: 126 FGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKI 185 Query: 56 RLYDIRTTNPNPVASFEGHRGNVTS-----VSFQQDNRWMVTSSEDGTIKVW 102 + + + +GH V + +S + R V+ D +K+W Sbjct: 186 SIVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIW 237 >3C9C-A nrPDB Length = 432 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 44/164 (26%), Positives = 71/164 (43%), Gaps = 17/164 (10%) Query: 5 LVSAGYDHTIRFWEA-LTGVCSRTIQHSDSQVNRLEITND-------KKLLAT-AGHQNV 55 L+SA DHTI W+ T R I + + D + L + A Q + Sbjct: 199 LLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQKL 258 Query: 56 RLYDIRTTN-PNPVASFEGHRGNVTSVSFQQDNRWMV-TSSEDGTIKVWDVRSPSIPRN- 112 ++D R N P + + H V +SF + +++ T S D T+ +WD+R+ + + Sbjct: 259 MIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS 318 Query: 113 -YKHNAPVNEVVIHP-NQGELISCDRDGNIRIWDL---GENQCT 151 H + +V P N+ L S D + +WDL GE Q T Sbjct: 319 FESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQST 362 Score = 33.9 bits (76), Expect = 0.080, Method: Compositional matrix adjust. Identities = 50/230 (21%), Positives = 89/230 (38%), Gaps = 66/230 (28%) Query: 67 PVASFEGHRGNVTSVSFQQD-NRWMVTSSEDGTIKVWDVRSPSIPRNYK----------H 115 P GH+ +S+ + N +++++S+D TI +WD+ + P+ ++ H Sbjct: 175 PDLRLRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDIN--ATPKEHRVIDAKNIFTGH 232 Query: 116 NAPVNEVVIHPNQGELI-SCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSML 174 A V +V H L S D + IWD N + Sbjct: 233 TAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTS----------------------- 269 Query: 175 AAANTKGNCYVWEMPNHTDASHLKPVT--KFRAHSTYITRILLSSDVKHLATCSADHTAR 232 P+HT +H V F +S +I LAT SAD T Sbjct: 270 -------------KPSHTVDAHTAEVNCLSFNPYSEFI-----------LATGSADKTVA 305 Query: 233 VWSIDDDFKLET-TLDGHQRWVWDCAFSA-DSAYLVTASSDHYVRLWDLS 280 +W + + KL+ + + H+ ++ +S + L ++ +D + +WDLS Sbjct: 306 LWDL-RNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLS 354 >6F1U-h nrPDB Length = 612 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 32/128 (25%), Positives = 63/128 (49%), Gaps = 10/128 (7%) Query: 71 FEGHRGNVT------SVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAP-VNEVV 123 FEGH+G +T +V + VTSS D T+K+W ++ +++ NA V +V+ Sbjct: 446 FEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTKNNKPLYSFEDNAGYVYDVM 505 Query: 124 IHPNQGELISC-DRDGNIRIWDLGENQ--CTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 P L +C D G + +W+L + T ++ E + +L + G +A +++ Sbjct: 506 WSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSE 565 Query: 181 GNCYVWEM 188 G ++++ Sbjct: 566 GQIVIYDV 573 Score = 28.1 bits (61), Expect = 5.0, Method: Compositional matrix adjust. Identities = 24/91 (26%), Positives = 41/91 (45%), Gaps = 5/91 (5%) Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSED-GTIKVW----DVRSPSIPRNYKHN 116 T N P+ SFE + G V V + + + + G + +W D P+ + + N Sbjct: 485 TKNNKPLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGN 544 Query: 117 APVNEVVIHPNQGELISCDRDGNIRIWDLGE 147 +N V + E+ D +G I I+D+GE Sbjct: 545 PALNRVRWTHSGREIAVGDSEGQIVIYDVGE 575 Score = 26.9 bits (58), Expect = 9.6, Method: Compositional matrix adjust. Identities = 53/219 (24%), Positives = 82/219 (37%), Gaps = 39/219 (17%) Query: 90 MVTSSEDGTIKVWDVRS---------PSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNI 140 +V + G I +WD RS P + H VV N LIS DG I Sbjct: 322 VVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKI 381 Query: 141 RIWD---LGENQCTHQLTPEDDTSLQSLSM-------------ASDGSMLAAANTKGNCY 184 W L Q + +L + ++ SM + +GS+ A Sbjct: 382 CSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAG 441 Query: 185 VWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHL-ATCSADHTARVWSIDDDFKLE 243 + EM H P+T H+ + + D HL T S D T ++WS ++ L Sbjct: 442 ISEM----FEGHQGPITGIHCHAA-----VGAVDFSHLFVTSSFDWTVKLWSTKNNKPL- 491 Query: 244 TTLDGHQRWVWDCAFSADSAYLVTASSDHYVR--LWDLS 280 + + + +V+D +S L A D R LW+L+ Sbjct: 492 YSFEDNAGYVYDVMWSPTHPALF-ACVDGMGRLDLWNLN 529 >5Y1U-A nrPDB Length = 456 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 43/168 (25%), Positives = 77/168 (45%), Gaps = 16/168 (9%) Query: 5 LVSAGYDHTIRFWEALTG------VCSRTIQHSDSQVNR---LEITNDKKLLATAGHQNV 55 L+SA DHTI W+ V ++TI + V + ++ + A Q + Sbjct: 224 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 283 Query: 56 RLYDIRTTN-PNPVASFEGHRGNVTSVSFQQDNRWMV-TSSEDGTIKVWDVRSPSIPRN- 112 ++D R+ N P S + H V +SF + +++ T S D T+ +WD+R+ + + Sbjct: 284 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS 343 Query: 113 -YKHNAPVNEVVIHP-NQGELISCDRDGNIRIWDLGENQCTHQLTPED 158 H + +V P N+ L S D + +WDL ++ + +PED Sbjct: 344 FESHKDEIFQVQWSPHNETILASSGTDRRLNVWDL--SKIGEEQSPED 389 Score = 30.8 bits (68), Expect = 0.77, Method: Compositional matrix adjust. Identities = 50/231 (21%), Positives = 89/231 (38%), Gaps = 66/231 (28%) Query: 66 NPVASFEGHRGNVTSVSFQQD-NRWMVTSSEDGTIKVWDVRSPSIPRNYK---------- 114 NP GH+ +S+ + + ++++S+D TI +WD+ + +P+ K Sbjct: 199 NPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISA--VPKEGKVVDAKTIFTG 256 Query: 115 HNAPVNEVVIHPNQGELI-SCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSM 173 H A V +V H L S D + IWD N + Sbjct: 257 HTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSK--------------------- 295 Query: 174 LAAANTKGNCYVWEMPNHTDASHLKPVT--KFRAHSTYITRILLSSDVKHLATCSADHTA 231 P+H+ +H V F +S +I LAT SAD T Sbjct: 296 ---------------PSHSVDAHTAEVNCLSFNPYSEFI-----------LATGSADKTV 329 Query: 232 RVWSIDDDFKLET-TLDGHQRWVWDCAFSA-DSAYLVTASSDHYVRLWDLS 280 +W + + KL+ + + H+ ++ +S + L ++ +D + +WDLS Sbjct: 330 ALWDL-RNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLS 379 >1NR0-A nrPDB Length = 611 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 41/194 (21%), Positives = 83/194 (42%), Gaps = 13/194 (6%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLA-TAGHQNVRLYDIRTT 63 ++S D+T+ +E T V+ + D L A T G + LY+ Sbjct: 163 IISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYN--GV 220 Query: 64 NPNPVASFE-------GHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHN 116 + FE H G+V +++ D + ++S D TIK+W+V + + + Sbjct: 221 DGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVG 280 Query: 117 APV--NEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSML 174 + ++ I + L+S +G I + E Q+ + ++ +LS ++DG L Sbjct: 281 TRIEDQQLGIIWTKQALVSISANGFINFVNP-ELGSIDQVRYGHNKAITALSSSADGKTL 339 Query: 175 AAANTKGNCYVWEM 188 +A+ +G+ W++ Sbjct: 340 FSADAEGHINSWDI 353 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 34/127 (26%), Positives = 61/127 (48%), Gaps = 10/127 (7%) Query: 26 RTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVA---SFEGHRGNVTSVS 82 +TI H +++ + +N+ L A Q+ ++ N +A S+ H V VS Sbjct: 486 KTIVHP-AEITSVAFSNNGAFLV-ATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVS 543 Query: 83 FQQDNRWMVTSSEDGTIKVWDVRSPS----IPRNYKHNAPVNEVVIHPNQGELISCDRDG 138 + DN + T S D ++ VW++ PS I + + VN VI N+ ++S +D Sbjct: 544 WSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNS-VIWLNETTIVSAGQDS 602 Query: 139 NIRIWDL 145 NI+ W++ Sbjct: 603 NIKFWNV 609 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 58/274 (21%), Positives = 108/274 (39%), Gaps = 32/274 (11%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQ-HSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTT 63 + SA D TI+ W T +TI + + +L I K+ L + I Sbjct: 254 IASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGF----INFV 309 Query: 64 NPNPVASFE----GHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKH-NAP 118 NP + S + GH +T++S D + + ++ +G I WD+ + R + +A Sbjct: 310 NPE-LGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHAT 368 Query: 119 VNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMA--SDGSMLAA 176 + + ++G+L + D ++++ G + + S Q L +A +DG + A Sbjct: 369 MITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVA 428 Query: 177 ANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITR----ILLSSDVKHLATCSADHTAR 232 A CY H+ + + I+ + LS+D + +A D Sbjct: 429 A-----CY----------KHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVH 473 Query: 233 VWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLV 266 V+ + E H + AFS + A+LV Sbjct: 474 VYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLV 507 Score = 33.5 bits (75), Expect = 0.10, Method: Compositional matrix adjust. Identities = 55/279 (19%), Positives = 105/279 (37%), Gaps = 52/279 (18%) Query: 52 HQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSED----GTIKVWDVRSP 107 H NVR++D T + G V +S+ +++ + E G + ++D + Sbjct: 80 HGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTS 139 Query: 108 SIPRNYKHNAPVNEVVIHPNQG-ELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLS 166 + + A +N V P++ +IS D + I++ G E + S+ Sbjct: 140 NGNLTGQARA-MNSVDFKPSRPFRIISGSDDNTVAIFE-GPPFKFKSTFGEHTKFVHSVR 197 Query: 167 MASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVT-KFRAHSTYITRILLSSDVKHLATC 225 DGS+ A+ G ++ + T + + K AHS + + S D +A+ Sbjct: 198 YNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASA 257 Query: 226 SADHTARVWSIDDDFKLETTLD-------------------------------------- 247 SAD T ++W++ K+E T+ Sbjct: 258 SADKTIKIWNV-ATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSI 316 Query: 248 -----GHQRWVWDCAFSADSAYLVTASSDHYVRLWDLST 281 GH + + + SAD L +A ++ ++ WD+ST Sbjct: 317 DQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDIST 355 Score = 32.3 bits (72), Expect = 0.29, Method: Compositional matrix adjust. Identities = 35/157 (22%), Positives = 64/157 (40%), Gaps = 25/157 (15%) Query: 133 SCDRDGNIRIWDLGENQCTHQL---TPEDDTSLQSLSMASDGSMLAAANTK----GNCYV 185 S D GN+RIWD Q TH L P ++ +S S+ +AA G+ ++ Sbjct: 76 SGDVHGNVRIWD--TTQTTHILKTTIPVFSGPVKDISWDSESKRIAAVGEGRERFGHVFL 133 Query: 186 WEM----PNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFK 241 ++ N T + F+ + RI+ SD D+T ++ FK Sbjct: 134 FDTGTSNGNLTGQARAMNSVDFKPSRPF--RIISGSD---------DNTVAIFE-GPPFK 181 Query: 242 LETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWD 278 ++T H ++V ++ D + + D + L++ Sbjct: 182 FKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYN 218 Score = 30.8 bits (68), Expect = 0.83, Method: Compositional matrix adjust. Identities = 25/145 (17%), Positives = 61/145 (42%), Gaps = 4/145 (2%) Query: 136 RDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDAS 195 +D + ++ L + T + S++ +++G+ L A + + + N+ + + Sbjct: 468 QDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELA 527 Query: 196 HLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDG-HQRWVW 254 H + H+ + + S D LAT S D++ VW+++ + G H Sbjct: 528 H---TNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSV 584 Query: 255 DCAFSADSAYLVTASSDHYVRLWDL 279 + + +V+A D ++ W++ Sbjct: 585 NSVIWLNETTIVSAGQDSNIKFWNV 609 >3JB9-S nrPDB Length = 488 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 24/90 (26%), Positives = 42/90 (46%), Gaps = 1/90 (1%) Query: 47 LATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMV-TSSEDGTIKVWDVR 105 L AG +N L T++ N + F H V ++ F ++ W+V T+++D I +WD+R Sbjct: 347 LFVAGLENGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLR 406 Query: 106 SPSIPRNYKHNAPVNEVVIHPNQGELISCD 135 + + V V + L+S D Sbjct: 407 KSELVQKIPLQTKVAAVSLDITSQLLVSSD 436 >4BH6-A nrPDB Length = 308 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 39/230 (16%), Positives = 94/230 (40%), Gaps = 14/230 (6%) Query: 14 IRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPV-ASFE 72 + ++ + C RT+ ++R+ + + T+G ++ R+ P+P + E Sbjct: 86 VEIYDVMKRKCIRTLS---GHIDRVACLSWNNHVLTSGSRDHRILHRDVRMPDPFFETIE 142 Query: 73 GHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQGEL 131 H V + + + + + D + V++ S S + +H A V + P++ + Sbjct: 143 SHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGV 202 Query: 132 ISCD---RDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEM 188 ++ D ++IW++ + + S ++ + + +K N +W Sbjct: 203 LATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLW-- 260 Query: 189 PNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDD 238 D + + P+ + HS + + LS+D + + + D T R W + D Sbjct: 261 ----DCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKLFD 306 Score = 33.5 bits (75), Expect = 0.13, Method: Compositional matrix adjust. Identities = 23/105 (21%), Positives = 47/105 (44%), Gaps = 6/105 (5%) Query: 4 ILVSAG--YDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQ--NVRLYD 59 +L + G D ++ W T + I N + N +L+ + G+ N+ L+D Sbjct: 202 VLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWD 261 Query: 60 IRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDV 104 + +P +A +GH V ++ D +V+ + D T++ W + Sbjct: 262 CNSMDP--IAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKL 304 >5TF2-A nrPDB Length = 407 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 22/75 (29%), Positives = 37/75 (49%), Gaps = 4/75 (5%) Query: 81 VSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDGN 139 V F DN + T DG ++VW V S +K H + ++ + P+ G+L++ RD Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPD-GKLVTVGRDLK 236 Query: 140 IRIWDLGENQCTHQL 154 +W ++Q QL Sbjct: 237 ASVWQ--KDQLVTQL 249 Score = 30.8 bits (68), Expect = 0.85, Method: Compositional matrix adjust. Identities = 12/34 (35%), Positives = 20/34 (58%) Query: 258 FSADSAYLVTASSDHYVRLWDLSTREIVRQYGGH 291 F+ D+ L T +D YVR+W + + E V ++ H Sbjct: 180 FNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAH 213 >5BJS-A nrPDB Length = 605 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 33/123 (26%), Positives = 57/123 (46%), Gaps = 11/123 (8%) Query: 43 DKKLLATAGHQ-NVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTS-SEDGTIK 100 D+ LL AG++ NV++Y++ T + GH G + ++ N +++ S S+D TI+ Sbjct: 147 DQPLLCIAGNEGNVKVYNV--TEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIR 204 Query: 101 VWDV-----RSPS--IPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQ 153 +W + + P I H+ + V H N ++S D I +W L E H Sbjct: 205 IWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPEFPNEHM 264 Query: 154 LTP 156 P Sbjct: 265 EIP 267 Score = 34.3 bits (77), Expect = 0.075, Method: Compositional matrix adjust. Identities = 49/225 (21%), Positives = 85/225 (37%), Gaps = 48/225 (21%) Query: 79 TSVSFQQDNRWMVTSSEDGTI----------KVWDVRSPSIPRNYKHNAPVNEVVIH--- 125 TS FQ D +++ +DG++ K + P P + + + V+ Sbjct: 56 TSFIFQDDYKYL---GDDGSVSQDLAEFFDVKFYPYSPPGAPPVFAATSKKHAVICRLTQ 112 Query: 126 -----PNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 N E+I RD D E C S S +D +L A + Sbjct: 113 TTDKDANPCEIIQLIRD------DGNEANCA---------SCWSKDPITDQPLLCIAGNE 157 Query: 181 GNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHL-ATCSADHTARVWSIDDD 239 GN V+ N T+ + + H I + S ++ A+ S D T R+WS+ + Sbjct: 158 GNVKVY---NVTEGKLYRTLV---GHGGGINDLATSPANPYIIASASDDTTIRIWSLAPE 211 Query: 240 FKLETTL-----DGHQRWVWDCAFSADSAYLVTASSDHYVRLWDL 279 + + + +GH + AF + Y+++A D + LW L Sbjct: 212 HEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWAL 256 Score = 32.0 bits (71), Expect = 0.34, Method: Compositional matrix adjust. Identities = 26/129 (20%), Positives = 57/129 (44%), Gaps = 11/129 (8%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEIT--NDKKLLATAGHQNVRLYDIR 61 +L AG + ++ + G RT+ +N L + N + + + +R++ + Sbjct: 150 LLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIWSLA 209 Query: 62 TTNPNP----VASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNA 117 + + EGH ++ SV+F + R+++++ D I +W + P P N Sbjct: 210 PEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWAL--PEFP-NEHMEI 266 Query: 118 PVNEVVIHP 126 P+ V+ +P Sbjct: 267 PI--VIYYP 273 >5K19-A nrPDB Length = 569 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 53/237 (22%), Positives = 87/237 (36%), Gaps = 34/237 (14%) Query: 97 GTIKVWDVRSPSIPRNYKHNAP----VNEVVIHPNQGELISCDRDGNIRIWDLGENQCTH 152 G K D+ P R YK P N + L+ G +++ D + + + Sbjct: 80 GVRKAADLSKPIDKRIYKGTQPTCHDFNHLTATAESVSLLVGFSAGQVQLIDPIKKETSK 139 Query: 153 QLTPE---DDTSLQSLS-MASDGSMLAAANTKGNCYVWEMPN--HTDASHLK-------- 198 E D + + + + S+ A++ GN Y++ + + T A H + Sbjct: 140 LFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESF 199 Query: 199 ------------PVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTL 246 P+ K+ + S D K LA S D RV++ D +L T+ Sbjct: 200 AVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDS-VELHGTM 258 Query: 247 DGHQRWVWDCAFSADSAYLVTASSDHYVRLWDL-STREIVRQYGGHHKGAVCVALND 302 + + +S D Y+VT D V +W R I R +G HK V V D Sbjct: 259 KSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHG--HKSWVSVVAFD 313 Score = 31.6 bits (70), Expect = 0.48, Method: Compositional matrix adjust. Identities = 22/97 (22%), Positives = 43/97 (44%), Gaps = 4/97 (4%) Query: 32 DSQVNRLEITNDKKLLATAGHQN-VRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWM 90 + +N + D K LA +R+++ + + + + + G + V + D +++ Sbjct: 220 EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELH--GTMKSYFGGLLCVCWSPDGKYI 277 Query: 91 VTSSEDGTIKVWD-VRSPSIPRNYKHNAPVNEVVIHP 126 VT ED + VW V I R + H + V+ V P Sbjct: 278 VTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDP 314 >3CFV-B nrPDB Length = 414 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 43/166 (25%), Positives = 74/166 (44%), Gaps = 17/166 (10%) Query: 1 MSVILVSAGYDHTIRFWEALTG------VCSRTIQHSDSQVNR---LEITNDKKLLATAG 51 +S L+SA DHT+ W+ G V ++ I S V + ++ + A Sbjct: 191 LSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVAD 250 Query: 52 HQNVRLYDIRT-TNPNPVASFEGHRGNVTSVSFQQDNRWMV-TSSEDGTIKVWDVRSPSI 109 Q + ++D R+ T P + H V +SF + +++ T S D T+ +WD+R+ + Sbjct: 251 DQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKL 310 Query: 110 PRN--YKHNAPVNEVVIHP-NQGELISCDRDGNIRIWDL---GENQ 149 + H + +V P N+ L S D + +WDL GE Q Sbjct: 311 KLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQ 356 Score = 30.0 bits (66), Expect = 1.2, Method: Compositional matrix adjust. Identities = 60/281 (21%), Positives = 108/281 (38%), Gaps = 73/281 (25%) Query: 24 CSRTIQHSDSQVNRLE-ITNDKKLLATAGHQNVRLYDIRTTNP---------NPVASFEG 73 C I H + +VNR + + ++AT + L T +P NP G Sbjct: 119 CEIKINH-EGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRG 177 Query: 74 HRGNVTSVSFQQD-NRWMVTSSEDGTIKVWDVRSPSIPRNYK----------HNAPVNEV 122 H+ +S+ + + ++++S+D T+ +WD+ + P+ K H+A V +V Sbjct: 178 HQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAG--PKEGKIVDAKAIFTGHSAVVEDV 235 Query: 123 VIHPNQGELI-SCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKG 181 H L S D + IWD N + + ++ A + Sbjct: 236 AWHLLHESLFGSVADDQKLMIWDTRSN-----------------TTSKPSHLVDAHTAEV 278 Query: 182 NCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFK 241 NC F +S +I LAT SAD T +W + + K Sbjct: 279 NCL-----------------SFNPYSEFI-----------LATGSADKTVALWDL-RNLK 309 Query: 242 LET-TLDGHQRWVWDCAFSA-DSAYLVTASSDHYVRLWDLS 280 L+ T + H+ ++ +S + L ++ +D + +WDLS Sbjct: 310 LKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLS 350 >5A31-R nrPDB Length = 386 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 39/230 (16%), Positives = 94/230 (40%), Gaps = 14/230 (6%) Query: 14 IRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPV-ASFE 72 + ++ + C RT+ ++R+ + + T+G ++ R+ P+P + E Sbjct: 155 VEIYDVMKRKCIRTLS---GHIDRVACLSWNNHVLTSGSRDHRILHRDVRMPDPFFETIE 211 Query: 73 GHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQGEL 131 H V + + + + + D + V++ S S + +H A V + P++ + Sbjct: 212 SHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGV 271 Query: 132 ISCD---RDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEM 188 ++ D ++IW++ + + S ++ + + +K N +W Sbjct: 272 LATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLW-- 329 Query: 189 PNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDD 238 D + + P+ + HS + + LS+D + + + D T R W + D Sbjct: 330 ----DCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKLFD 375 Score = 33.5 bits (75), Expect = 0.12, Method: Compositional matrix adjust. Identities = 24/110 (21%), Positives = 49/110 (44%), Gaps = 6/110 (5%) Query: 4 ILVSAG--YDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQ--NVRLYD 59 +L + G D ++ W T + I N + N +L+ + G+ N+ L+D Sbjct: 271 VLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWD 330 Query: 60 IRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSI 109 + +P +A +GH V ++ D +V+ + D T++ W + S+ Sbjct: 331 CNSMDP--IAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKLFDVSV 378 >5YZG-2 nrPDB Length = 646 Score = 38.5 bits (88), Expect = 0.003, Method: Compositional matrix adjust. Identities = 51/244 (20%), Positives = 85/244 (34%), Gaps = 40/244 (16%) Query: 68 VASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPN 127 V F H G + S++ + + +D +KV+DV + + K + P Sbjct: 126 VKHFRSHLGVIESIAVSSEGALFCSVGDDKAMKVFDVVNFDMINMLK-------LGYFPG 178 Query: 128 QGELISCDRD------------GNIRIWD-LGENQCTHQLTPEDDTSLQSLSMASDGSML 174 Q E I C D G I I+D G+NQ H + L + + + Sbjct: 179 QCEWIYCPGDAISSVAASEKSTGKIFIYDGRGDNQPLHIFDKLHTSPLTQIRLNPVYKAV 238 Query: 175 AAANTKGNCYVWEMPNHTDASHLKPVT----------KFRAHSTYITRILLSSDVKHLAT 224 +++ G W P H + K V +F Y T + S D K +AT Sbjct: 239 VSSDKSGMIEYWTGPPH-EYKFPKNVNWEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIAT 297 Query: 225 CSADHTARVWS---------IDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVR 275 +D R++ D+ + T L ++ + D F A VR Sbjct: 298 IGSDRKVRIFRFVTGKLMRVFDESLSMFTELQQMRQQLPDMEFGRRMAVERELEKVDAVR 357 Query: 276 LWDL 279 L ++ Sbjct: 358 LINI 361 Score = 37.4 bits (85), Expect = 0.008, Method: Compositional matrix adjust. Identities = 53/243 (21%), Positives = 102/243 (41%), Gaps = 41/243 (16%) Query: 74 HRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIP--RNYKHNAPVNEVVIHPNQGEL 131 HR +T V + + +++T+S DG +K W I ++++ + V E + ++G L Sbjct: 89 HRDVITHVVCTKTD-FIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSSEGAL 147 Query: 132 I-SCDRDGNIRIWD-----------LG--ENQCTHQLTPEDDTSLQSLSMASDGSMLAAA 177 S D ++++D LG QC P D S S+ A+ Sbjct: 148 FCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYCPGDAIS----------SVAASE 197 Query: 178 NTKGNCYVWE-----MPNHT-DASHLKPVTKFRAHSTYITRILLSSDVKHLA---TCSAD 228 + G ++++ P H D H P+T+ R + Y + ++SSD + T Sbjct: 198 KSTGKIFIYDGRGDNQPLHIFDKLHTSPLTQIRLNPVY--KAVVSSDKSGMIEYWTGPPH 255 Query: 229 HTARVWSIDDDFKLETTLDGHQR---WVWDCAFSADSAYLVTASSDHYVRLWDLSTREIV 285 +++ ++K +T L + + FS D + T SD VR++ T +++ Sbjct: 256 EYKFPKNVNWEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIATIGSDRKVRIFRFVTGKLM 315 Query: 286 RQY 288 R + Sbjct: 316 RVF 318 >3BG0-A nrPDB Length = 316 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 53/266 (19%), Positives = 108/266 (40%), Gaps = 30/266 (11%) Query: 45 KLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQD--NRWMVTSSEDGTIKVW 102 +L + ++V+++D+R +A GH G V V++ + + S D + +W Sbjct: 27 RLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIW 86 Query: 103 DVRSPSIPRNYK---HNAPVNEVVIHP-NQGELISC-DRDGNIRIWDL-GENQC-THQLT 155 + + ++++ H++ VN V P + G +++C DG I + GE Q ++ Sbjct: 87 REENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKIN 146 Query: 156 PEDDTSLQSLSMAS---DGSMLAAANTKGNCYV-----------WEMPNHTDASHLKPVT 201 ++S A GS++ + + Y+ ++ + K Sbjct: 147 NAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQ 206 Query: 202 KFRAHSTYITRILLSSDV----KHLATCSADHTARVWSIDD---DFKLETTLDGHQRWVW 254 K AHS ++ + + + +A+CS D +W+ DD + L VW Sbjct: 207 KLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVW 266 Query: 255 DCAFSADSAYLVTASSDHYVRLWDLS 280 ++S + L + D+ V LW S Sbjct: 267 HVSWSITANILAVSGGDNKVTLWKES 292 Score = 29.3 bits (64), Expect = 2.2, Method: Compositional matrix adjust. Identities = 28/89 (31%), Positives = 45/89 (50%), Gaps = 9/89 (10%) Query: 222 LATCSADHTARVWSIDDDFK-LETTLDGHQRWVWDCAFSADSAY---LVTASSDHYVRLW 277 LATCS+D + +++ + + + L L GH+ VW A+ A Y L + S D V +W Sbjct: 28 LATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAW-AHPMYGNILASCSYDRKVIIW 86 Query: 278 --DLSTREIVRQYGGHHKG--AVCVALND 302 + T E ++ GH +VC A +D Sbjct: 87 REENGTWEKSHEHAGHDSSVNSVCWAPHD 115 >5K0Y-T nrPDB Length = 329 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 25/85 (29%), Positives = 42/85 (49%), Gaps = 2/85 (2%) Query: 197 LKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDC 256 ++P+ + H IT+I + + L T + D VW + +L T + GH VW Sbjct: 1 MRPIL-LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYM-GHTGAVWCV 58 Query: 257 AFSADSAYLVTASSDHYVRLWDLST 281 D+ +++T S+D+ RLWD T Sbjct: 59 DADWDTKHVLTGSADNSCRLWDCET 83 Score = 36.2 bits (82), Expect = 0.017, Method: Compositional matrix adjust. Identities = 30/139 (21%), Positives = 53/139 (38%), Gaps = 13/139 (9%) Query: 17 WEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQN-VRLYD---------IRTTNPN 66 + A +G ++ Q+N ++++ + + TA N +L+D RT P Sbjct: 173 YSAKSGEVLVNVKEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFRTEPPR 232 Query: 67 PVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVR---SPSIPRNYKHNAPVNEVV 123 +A+ + +V Q+ TS+ G + R H P+N V Sbjct: 233 ELAALSPNYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVA 292 Query: 124 IHPNQGELISCDRDGNIRI 142 HP+ S DG +RI Sbjct: 293 FHPDGKSYSSGGEDGYVRI 311 Score = 36.2 bits (82), Expect = 0.018, Method: Compositional matrix adjust. Identities = 40/184 (21%), Positives = 71/184 (38%), Gaps = 18/184 (9%) Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNE 121 + N + ++ GH G V V D + ++T S D + ++WD + K N+ V Sbjct: 39 SVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRT 98 Query: 122 VVIHPNQGELISCDRDGN------IRIWDLG-----ENQCTHQLTPEDDTSLQSLSMASD 170 G +I D + +DL +N + P +D+ + S Sbjct: 99 CGFDFG-GNIIMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPL 157 Query: 171 GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHT 230 G + A + G N A + + + HS I I LS ++ T S D+T Sbjct: 158 GECIIAGHESGEL------NQYSAKSGEVLVNVKEHSRQINDIQLSREMTMFVTASKDNT 211 Query: 231 ARVW 234 A+++ Sbjct: 212 AKLF 215 Score = 32.7 bits (73), Expect = 0.22, Method: Compositional matrix adjust. Identities = 41/226 (18%), Positives = 84/226 (37%), Gaps = 23/226 (10%) Query: 71 FEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW-DVRSPSIPRNYKHNAPVNEVVIHPNQG 129 +GH ++T + + ++ + T ++D + VW V + H V V + Sbjct: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTK 65 Query: 130 ELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKG-NCYV--W 186 +++ D + R+WD + L + M + G C+V + Sbjct: 66 HVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFF 125 Query: 187 EMPNHTDASHLKPVTKFRAHSTYITR---------ILLSSDVKHLATCSADHTARVWSID 237 ++ + + + +P K + + IT I+ + L SA + ++ Sbjct: 126 DLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVK 185 Query: 238 DDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTRE 283 + H R + D S + VTAS D+ +L+D +T E Sbjct: 186 E----------HSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLE 221 Score = 29.3 bits (64), Expect = 2.0, Method: Compositional matrix adjust. Identities = 15/78 (19%), Positives = 34/78 (43%) Query: 50 AGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSI 109 AGH++ L + + + + H + + ++ VT+S+D T K++D + Sbjct: 163 AGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEH 222 Query: 110 PRNYKHNAPVNEVVIHPN 127 + ++ P + PN Sbjct: 223 QKTFRTEPPRELAALSPN 240 Score = 28.5 bits (62), Expect = 3.8, Method: Compositional matrix adjust. Identities = 15/53 (28%), Positives = 23/53 (43%) Query: 246 LDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCV 298 L GH+R + ++ + L T + D V +W E + Y GH CV Sbjct: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCV 58 >1PI6-A nrPDB Length = 615 Score = 37.7 bits (86), Expect = 0.006, Method: Compositional matrix adjust. Identities = 66/314 (21%), Positives = 119/314 (37%), Gaps = 75/314 (23%) Query: 55 VRLYDIRTTNPNPVASFEGHRGNV-TSVSFQ--QDNRWMVTSSEDGTIKVW----DVRSP 107 VR D + PV F GH +V T+V F + ++++ + E G + VW D S Sbjct: 43 VRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESN 102 Query: 108 SIPRNYKHN-----APVNEV----------VI---HPNQGELISCDRDGNIRIWDLGENQ 149 S+ N K P++++ V+ N G IS D GN G +Q Sbjct: 103 SVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEGRDNFGVFISWDS-GNSLGEVSGHSQ 161 Query: 150 CTHQLTPEDDTSLQSLSMASDGSML----------AAANT--KGNCYVWEMPNHTDASHL 197 + + ++S+++ DGS++ A+ T K +V ++ D+ Sbjct: 162 RINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEF 221 Query: 198 -------KPVTKFRAHSTYITRILLSS--------------DVKHLATCSADHTARVWSI 236 + ++ F S + + D + AT AD T RVW + Sbjct: 222 VITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDV 281 Query: 237 DDDFKLETTLDGHQRWVWD---------CAFSADSAYLVTASSDHYVRLWDLSTREIVRQ 287 TT Q+W D + + +++ S D + ++L E+++ Sbjct: 282 -------TTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKT 334 Query: 288 YGGHHKGAVCVALN 301 GH+KG + +N Sbjct: 335 ISGHNKGITALTVN 348 Score = 27.3 bits (59), Expect = 7.3, Method: Compositional matrix adjust. Identities = 19/102 (18%), Positives = 44/102 (43%), Gaps = 10/102 (9%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEI----TNDKKLLATAGHQNVRLYDI 60 + G D TIR W+ T C + Q+ ++ T + ++++ + + Y++ Sbjct: 267 FATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNFYEL 326 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW 102 + + + GH +T+++ +++ S DG I W Sbjct: 327 --GHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEW 362 >5WLC-LW nrPDB Length = 554 Score = 37.0 bits (84), Expect = 0.010, Method: Compositional matrix adjust. Identities = 16/56 (28%), Positives = 29/56 (51%) Query: 51 GHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRS 106 GH N + + P P+ RG V S++ + +M T+ D ++K+WD+R+ Sbjct: 250 GHSNGTVSLWSPSMPEPLVKLLSARGPVNSIAIDRSGYYMATTGADRSMKIWDIRN 305 Score = 29.6 bits (65), Expect = 1.8, Method: Compositional matrix adjust. Identities = 34/139 (24%), Positives = 60/139 (43%), Gaps = 20/139 (14%) Query: 46 LLATAGHQN-VRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDV 104 LL TAG ++ +D+ T V+ G +++ N M +GT+ +W Sbjct: 204 LLVTAGETGWLKYHDVSTGQL--VSELRTKAGPTMAMAQNPWNAVMHLGHSNGTVSLW-- 259 Query: 105 RSPSIP----RNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQL----TP 156 SPS+P + PVN + I + + + D +++IWD+ + H + TP Sbjct: 260 -SPSMPEPLVKLLSARGPVNSIAIDRSGYYMATTGADRSMKIWDIRNFKQLHSVESLPTP 318 Query: 157 EDDTSLQSLSMASDGSMLA 175 + S+ SD +LA Sbjct: 319 GTNVSI------SDTGLLA 331 >3JZG-A nrPDB Length = 402 Score = 35.8 bits (81), Expect = 0.024, Method: Compositional matrix adjust. Identities = 37/181 (20%), Positives = 72/181 (39%), Gaps = 24/181 (13%) Query: 114 KHNAPVNEVVIHPNQGELISCDRDGNIRIW------DLGENQCTHQLTPEDDTSLQSLSM 167 K P+ + N+ L C G IR+ D EN T T + +TS Sbjct: 67 KEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTS------ 120 Query: 168 ASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILL-SSDVKHLATCS 226 +LA A ++G + + ++ + + H I + D L + S Sbjct: 121 ---HPLLAVAGSRGIIRI------INPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVS 171 Query: 227 ADHTARVWSIDDD--FKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREI 284 DH R+W+I D + ++GH+ V + +++ DH ++LW ++++ + Sbjct: 172 KDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRM 231 Query: 285 V 285 + Sbjct: 232 M 232 Score = 34.7 bits (78), Expect = 0.049, Method: Compositional matrix adjust. Identities = 28/120 (23%), Positives = 53/120 (44%), Gaps = 7/120 (5%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEI--TNDKKLLATAGHQNVRLYDIR 61 +L AG IR +T C + + +N L+ + LL+ + +RL++I+ Sbjct: 123 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 182 Query: 62 TTNPNPV-ASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSP----SIPRNYKHN 116 T + EGHR V S + +++ D ++K+W + S +I +Y +N Sbjct: 183 TDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYN 242 Score = 30.4 bits (67), Expect = 0.92, Method: Compositional matrix adjust. Identities = 12/30 (40%), Positives = 19/30 (63%) Query: 261 DSAYLVTASSDHYVRLWDLSTREIVRQYGG 290 D L++ S DH +RLW++ T +V +GG Sbjct: 163 DPNLLLSVSKDHALRLWNIQTDTLVAIFGG 192 >6CHG-D nrPDB Length = 439 Score = 35.0 bits (79), Expect = 0.037, Method: Compositional matrix adjust. Identities = 59/277 (21%), Positives = 111/277 (40%), Gaps = 50/277 (18%) Query: 55 VRLYDIRTTNPNPVASFEGHRG----NVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS-I 109 + +YD+ + P +A H G +V SV + D R++ +S D K+WD+ P+ Sbjct: 51 IIIYDMDSLKP--IAMLGTHSGAHTRSVQSVCWSNDGRYLWSSGRDWYAKLWDMTQPTKC 108 Query: 110 PRNYKHNAP------------VNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPE 157 + YK + P + VV P L DR + L E Q Sbjct: 109 FQQYKFDGPLWSCHVVRWNVCIVTVVEEPTAYVLTLTDRQNAFHCFPLLEQD---QDISG 165 Query: 158 DDTSLQSLSMASDGSMLAAANTKG--NCYVWEMPNHTDASHLKPVTKFRAHSTYITRILL 215 +L + + S++ +KG N + ++ + + ++ + + + I +I++ Sbjct: 166 HGYTLVACPHPTIESIIITGTSKGWINAFQLDLESGFE-DKIRCCYEEKIANANIKQIII 224 Query: 216 SSDVKHLATCSADHTARVW-----------------SIDDDFKLETTLDGHQRWVWDCAF 258 S +A +D T R + SI+ + K + ++ R W+ F Sbjct: 225 SPSGTRIAINGSDRTIRQYQLIVEDNESEGGSSHSVSIELEHKYQDIIN---RLQWNTIF 281 Query: 259 SAD--SAYLVTA---SSDHYVRLWDLSTREIVRQYGG 290 ++ YLV + SS H + LW+ S+ +VR G Sbjct: 282 FSNHSGEYLVASAHGSSAHDLYLWETSSGSLVRVLEG 318 >5M89-A nrPDB Length = 329 Score = 34.7 bits (78), Expect = 0.057, Method: Compositional matrix adjust. Identities = 41/185 (22%), Positives = 75/185 (40%), Gaps = 23/185 (12%) Query: 8 AGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNP 67 G D + + + RT+ + V E T K ++ TA V++YD + Sbjct: 69 GGLDGKLDIYSVVANKVERTLDIGEP-VTATEWTGTKVVIGTA-KGWVKVYDAGRES--- 123 Query: 68 VASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS-IPRNYKHNAPVNEVVIHP 126 A+F+ H G VT ++ R + + D + +D+ + + R Y +A + HP Sbjct: 124 -ATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGERVARGYA-DAALTTCAFHP 181 Query: 127 NQGELISCDRDGNIRIWDLGENQCTHQLTPED------DTSLQSLSMASDGSMLAAANTK 180 + + + G+I ++ H T E T +Q+L+ + +G AA K Sbjct: 182 DGNLFAAGTQTGHILVF--------HTTTLEQAESFPLGTPIQALAFSENGFWFAATG-K 232 Query: 181 GNCYV 185 G V Sbjct: 233 GTSSV 237 >5WLC-LN nrPDB Length = 776 Score = 34.3 bits (77), Expect = 0.070, Method: Compositional matrix adjust. Identities = 22/90 (24%), Positives = 41/90 (45%), Gaps = 17/90 (18%) Query: 118 PVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQ-------LTPEDDTSLQSLSMASD 170 P ++ V+ + L+ + ++IW +G + T Q LT +DD ++ + S++ D Sbjct: 377 PYSKNVLVNKEQRLVVSWSESTVKIWTMGTDSSTEQNYKLVCKLTLKDDQNISTCSLSPD 436 Query: 171 GSMLAAANTKGNCYVWEMPNHTDASHLKPV 200 G +L P+ T HL+PV Sbjct: 437 GQVLVVGR----------PSTTKVFHLQPV 456 Score = 27.7 bits (60), Expect = 6.0, Method: Compositional matrix adjust. Identities = 32/159 (20%), Positives = 66/159 (41%), Gaps = 17/159 (10%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDK-KLLATAGHQNVRLYDI 60 S+ L S G + W+ TG+ R + + + I + + KL + V L DI Sbjct: 111 SLRLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISINDSQDKLSVGCDNGTVVLIDI 170 Query: 61 RTTNPNPV---ASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVR-----------S 106 + P + V ++++++D+ +++ DG I++W + + Sbjct: 171 -SGGPGVLEHDTILMRQEARVLTLAWKKDD-FVIGGCSDGRIRIWSAQKNDENMGRLLHT 228 Query: 107 PSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDL 145 + + K + V V+ P ++ S D G+I+ WD Sbjct: 229 MKVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFWDF 267 >5CXB-B nrPDB Length = 369 Score = 34.3 bits (77), Expect = 0.077, Method: Compositional matrix adjust. Identities = 13/34 (38%), Positives = 20/34 (58%) Query: 71 FEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDV 104 F GH G V SV+ + T +DGT++VW++ Sbjct: 17 FRGHEGRVRSVAIDPTGVALATGGDDGTVRVWEL 50 Score = 32.0 bits (71), Expect = 0.33, Method: Compositional matrix adjust. Identities = 21/59 (35%), Positives = 31/59 (52%), Gaps = 3/59 (5%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQ-HSDSQVN--RLEITNDKKLLATAGHQNVRL 57 V L + G D T+R WE LTG +++ + D VN R T D +LA A +++ L Sbjct: 33 GVALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNTVRWRPTKDTFILAAAAGEDIFL 91 >2AQ5-A nrPDB Length = 402 Score = 33.9 bits (76), Expect = 0.082, Method: Compositional matrix adjust. Identities = 32/117 (27%), Positives = 52/117 (44%), Gaps = 13/117 (11%) Query: 73 GHRGNVTSVSFQQDNRWMVTS-SEDGTIKVWDV---------RSPSIPRNYKHNAPVNEV 122 GH V +++ N ++ S SED T+ VW++ R P I H V V Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLE-GHTKRVGIV 137 Query: 123 VIHPN-QGELISCDRDGNIRIWDLGENQCTHQLTPE-DDTSLQSLSMASDGSMLAAA 177 HP Q L+S D I +WD+G L P+ ++ S+ + DG+++ + Sbjct: 138 AWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTS 194 >3I2N-A nrPDB Length = 357 Score = 33.9 bits (76), Expect = 0.083, Method: Compositional matrix adjust. Identities = 23/102 (22%), Positives = 47/102 (46%), Gaps = 14/102 (13%) Query: 55 VRLYDIRTTNPNPVASFEGHR----GNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIP 110 ++LY+I+ + + E + G + S QQ R++ T G + +W++ +P +P Sbjct: 46 IQLYEIQHGDLKLLREIEKAKPIKCGTFGATSLQQ--RYLATGDFGGNLHIWNLEAPEMP 103 Query: 111 --RNYKHNAPVNEVVIHPNQG------ELISCDRDGNIRIWD 144 H +N + G E+++ RDG +++WD Sbjct: 104 VYSVKGHKEIINAIDGIGGLGIGEGAPEIVTGSRDGTVKVWD 145 Score = 29.3 bits (64), Expect = 2.0, Method: Compositional matrix adjust. Identities = 17/50 (34%), Positives = 24/50 (48%), Gaps = 6/50 (12%) Query: 67 PVASFEGHRGNVTSVSFQQDNRW------MVTSSEDGTIKVWDVRSPSIP 110 PV S +GH+ + ++ +VT S DGT+KVWD R P Sbjct: 103 PVYSVKGHKEIINAIDGIGGLGIGEGAPEIVTGSRDGTVKVWDPRQKDDP 152 >5A9Q-7 nrPDB Length = 360 Score = 33.1 bits (74), Expect = 0.16, Method: Compositional matrix adjust. Identities = 38/136 (27%), Positives = 57/136 (41%), Gaps = 19/136 (13%) Query: 74 HRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS---IPRNYK-HNAPVNEVV-IHPNQ 128 H+ + VSF R M T S D ++KVWD ++K H+ V V HP Sbjct: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70 Query: 129 GE-LISCDRDGNIRIWD----------LGENQCTHQLTPEDD-TSLQSLSMASD--GSML 174 G+ L SC D +W+ G++ + T D TS+ + A G ML Sbjct: 71 GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLML 130 Query: 175 AAANTKGNCYVWEMPN 190 A + G ++E P+ Sbjct: 131 ATCSADGIVRIYEAPD 146 Score = 29.3 bits (64), Expect = 2.1, Method: Compositional matrix adjust. Identities = 30/140 (21%), Positives = 56/140 (40%), Gaps = 12/140 (8%) Query: 115 HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGEN---QCTHQLTPEDDTSLQ-SLSMASD 170 H +++V + + +C D ++++WD E+ CT + + + + Sbjct: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70 Query: 171 GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKH--------L 222 G +LA+ + VWE L+ + + +T + +DVK L Sbjct: 71 GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLML 130 Query: 223 ATCSADHTARVWSIDDDFKL 242 ATCSAD R++ D L Sbjct: 131 ATCSADGIVRIYEAPDVMNL 150 >5AMS-A nrPDB Length = 431 Score = 32.7 bits (73), Expect = 0.20, Method: Compositional matrix adjust. Identities = 20/70 (28%), Positives = 34/70 (48%), Gaps = 1/70 (1%) Query: 200 VTKFRAHSTYITRILLSSDVKHLATCSADHTARVW-SIDDDFKLETTLDGHQRWVWDCAF 258 +T F H+ + I ++ + T D+ A +W S K TL G+ V C+F Sbjct: 58 LTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSF 117 Query: 259 SADSAYLVTA 268 +++ +LVTA Sbjct: 118 TSEGGFLVTA 127 >5WLC-LV nrPDB Length = 707 Score = 31.2 bits (69), Expect = 0.53, Method: Compositional matrix adjust. Identities = 36/165 (21%), Positives = 70/165 (42%), Gaps = 13/165 (7%) Query: 35 VNRLEITNDKKLLATAGHQNV-RLYDIRTTNPNPVASFEGHRGN----VTSVSFQQDNRW 89 VN + I LLA NV +D R+ + E + N VT+ SF+ D Sbjct: 183 VNHVSINEVNGLLAAGTETNVVEFWDPRSRSRVSKLYLENNIDNRPFQVTTTSFRNDGLT 242 Query: 90 MVTSSEDGTIKVWDVRS--PSIPRNYKHNAPVNEVVIHPNQG---ELISCDRDGNIRIWD 144 + +G ++D+R+ PSI ++ + + +++ N G ++++CD+ +IWD Sbjct: 243 FACGTSNGYSYIYDLRTSEPSIIKDQGYGFDIKKIIWLDNVGTENKIVTCDKRI-AKIWD 301 Query: 145 LGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMP 189 + + + P D + + M AN + + +P Sbjct: 302 RLDGKAYASMEPSVD--INDIEHVPGTGMFFTANESIPMHTYYIP 344 >5IT7-II nrPDB Length = 216 Score = 30.8 bits (68), Expect = 0.68, Method: Compositional matrix adjust. Identities = 26/85 (30%), Positives = 39/85 (45%), Gaps = 21/85 (24%) Query: 137 DGNIRIWDLGENQ--------CTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEM 188 D IRI+DLG+ + C H ++ E L+ LS + L AA N Y+ +M Sbjct: 26 DSKIRIYDLGKKKATVDEFPLCVHLVSNE----LEQLSSEA----LEAARITANKYITKM 77 Query: 189 PNHTDASHLKPVTKFRAHSTYITRI 213 D+ HL + R H ++ RI Sbjct: 78 TGR-DSFHL----RVRVHPFHVLRI 97 >4J0X-A nrPDB Length = 451 Score = 30.8 bits (68), Expect = 0.75, Method: Compositional matrix adjust. Identities = 34/165 (20%), Positives = 63/165 (38%), Gaps = 6/165 (3%) Query: 32 DSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMV 91 D Q+ + +IT+ K + I T+ + EGH + +V+ D +++V Sbjct: 71 DLQLTKYDITDFSKRPKKLKYAKGGAKYIPTSKHEYENTTEGHYDEILTVAASPDGKYVV 130 Query: 92 TSSEDGTIKVWDVRSPS----IPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGE 147 T D + VW S S IP V + N +L + D IR + + + Sbjct: 131 TGGRDRKLIVWSTESLSPVKVIPTK-DRRGEVLSLAFRKNSDQLYASCADFKIRTYSINQ 189 Query: 148 NQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHT 192 L D ++A + + A + +W++P+ T Sbjct: 190 FSQLEILYGHHDIVEDISALAMERCVTVGARDR-TAMLWKIPDET 233 >4FHN-A nrPDB Length = 394 Score = 30.8 bits (68), Expect = 0.75, Method: Compositional matrix adjust. Identities = 21/68 (30%), Positives = 34/68 (50%), Gaps = 6/68 (8%) Query: 83 FQQDNRW----MVTSSEDGTIKVWDVRSPS-IPRNYKHNAPVNEVVIHP-NQGELISCDR 136 + DNR + + +D T+ +W + I Y ++P V P N +LI +R Sbjct: 149 YSADNRLAEQVIASVGDDCTLIIWRLTDEGPILAGYPLSSPGISVQFRPSNPNQLIVGER 208 Query: 137 DGNIRIWD 144 +GNIRI+D Sbjct: 209 NGNIRIFD 216 >1CKM-A nrPDB Length = 330 Score = 30.4 bits (67), Expect = 0.97, Method: Compositional matrix adjust. Identities = 14/45 (31%), Positives = 24/45 (53%), Gaps = 7/45 (15%) Query: 90 MVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISC 134 + SEDGTI ++D N + N PV ++ + N+G ++ C Sbjct: 245 FIIMSEDGTIGIFD-------PNLRKNVPVGKLDGYYNKGSIVEC 282 >2I3T-A nrPDB Length = 341 Score = 30.4 bits (67), Expect = 1.0, Method: Compositional matrix adjust. Identities = 12/39 (30%), Positives = 22/39 (56%) Query: 258 FSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAV 296 FS +L TA SD + W+L TR+ ++ + ++ +V Sbjct: 259 FSPRHKFLYTAGSDGIISCWNLQTRKKIKNFAKFNEDSV 297 >5MC6-j nrPDB Length = 397 Score = 29.6 bits (65), Expect = 1.6, Method: Compositional matrix adjust. Identities = 33/165 (20%), Positives = 70/165 (42%), Gaps = 30/165 (18%) Query: 104 VRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPE-----D 158 V SP P + + ++E +G + + +G ++I +L + + + + Sbjct: 179 VESPMTPSQFATSVDISE------RGLIATGFNNGTVQISELSTLRPLYNFESQHSMINN 232 Query: 159 DTSLQSLSMASDGSMLAAA---NTKGNCYVWE-----------MPNHTDASHLKPVTKFR 204 S++S+ + GS+LA A N+ G ++E +P H+ + L Sbjct: 233 SNSIRSVKFSPQGSLLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEF---- 288 Query: 205 AHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGH 249 AHS+++ + + + L + D R W + ++ TTL+ H Sbjct: 289 AHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERI-TTLNMH 332 Score = 29.3 bits (64), Expect = 2.1, Method: Compositional matrix adjust. Identities = 13/44 (29%), Positives = 20/44 (45%) Query: 248 GHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGH 291 H WV +F+ L +A D +R WD+ T+E + H Sbjct: 289 AHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERITTLNMH 332 >3MWP-A nrPDB Length = 577 Score = 29.6 bits (65), Expect = 1.7, Method: Compositional matrix adjust. Identities = 23/103 (22%), Positives = 42/103 (40%), Gaps = 14/103 (13%) Query: 40 ITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWM--------- 90 +T+D L+ A + ++ IRT P S + GN++S Q + Sbjct: 102 LTSDDLLILAADLEKLKSKVIRTERP---LSAGVYMGNLSSQQLDQRRALLNMIGMSGGN 158 Query: 91 --VTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGEL 131 + DG ++VWDV++ + N P + QG++ Sbjct: 159 QGARAGRDGVVRVWDVKNAELLNNQFGTMPSLTLACLTKQGQV 201 >5SUM-A nrPDB Length = 468 Score = 29.6 bits (65), Expect = 1.7, Method: Compositional matrix adjust. Identities = 16/44 (36%), Positives = 25/44 (56%), Gaps = 2/44 (4%) Query: 261 DSAYLVTASSDHYVRLWDLST-REIVRQYGGHHKGAVCVALNDV 303 D YL+ D YVR++D+ T + +V+ Y G + V L+DV Sbjct: 376 DGKYLLQGGLDRYVRIFDIKTNKMLVKVYVGSRINFI-VMLDDV 418 >4PSX-B nrPDB Length = 401 Score = 29.6 bits (65), Expect = 1.7, Method: Compositional matrix adjust. Identities = 43/181 (23%), Positives = 71/181 (39%), Gaps = 47/181 (25%) Query: 5 LVSAGYDHTIRFWEALTG------VCSRTIQHSDSQVNRLEITNDKK-------LLATAG 51 L+S DHT+ WE +G V + HSD I ND K L T Sbjct: 176 LLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSD-------IINDNKWHNFNKDLFGTVS 228 Query: 52 HQN-VRLYDIRTTN--------PNPV--ASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIK 100 + +++ D+R N P P +F H N+ + + D + Sbjct: 229 EDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNL-----------LAAAGMDSYVY 277 Query: 101 VWDVRSPSIPRNYK--HNAPVNEVVIHPN-QGELISCDRDGNIRIWDLGENQCTHQLTPE 157 ++D+R+ P ++ H VN + + G ++S D + +WDL Q + TP+ Sbjct: 278 LYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDL--KQIGAEQTPD 335 Query: 158 D 158 D Sbjct: 336 D 336 Score = 28.1 bits (61), Expect = 4.8, Method: Compositional matrix adjust. Identities = 23/84 (27%), Positives = 40/84 (47%), Gaps = 4/84 (4%) Query: 200 VTKFRAHSTYITRI-LLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAF 258 +T H ITR + D +AT + T ++S + L++TL H+ + +F Sbjct: 111 ITAKYEHEEEITRARYMPQDPNIVATINGQGTTFLYSRSE--GLQSTLKFHKDNGYALSF 168 Query: 259 SA-DSAYLVTASSDHYVRLWDLST 281 S L++ S DH V LW++ + Sbjct: 169 STLVKGRLLSGSDDHTVALWEVGS 192 >5WLC-SG nrPDB Length = 573 Score = 29.6 bits (65), Expect = 1.8, Method: Compositional matrix adjust. Identities = 27/125 (21%), Positives = 50/125 (40%), Gaps = 6/125 (4%) Query: 72 EGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS----IPRNYKHNAPVNEVVIHPN 127 EGH + +V+ D +++VT D + VW S S IP + V + N Sbjct: 233 EGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRR-GEVLSLAFRKN 291 Query: 128 QGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWE 187 +L + D IR + + + L D ++A + + A + +W+ Sbjct: 292 SDQLYASCADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGARDR-TAMLWK 350 Query: 188 MPNHT 192 +P+ T Sbjct: 351 IPDET 355 >6IYY-A nrPDB Length = 317 Score = 29.6 bits (65), Expect = 1.8, Method: Compositional matrix adjust. Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 4/68 (5%) Query: 42 NDKKLLATAGHQ--NVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGT- 98 ++ LLA G +V+L D+ +T PV H G ++ ++ + T+SE GT Sbjct: 142 SNNSLLAFPGTHTGHVQLVDLASTEKPPV-DIPAHEGVLSCIALNLQGTRIATASEKGTL 200 Query: 99 IKVWDVRS 106 I+++D S Sbjct: 201 IRIFDTSS 208 >4AV8-A nrPDB Length = 339 Score = 29.3 bits (64), Expect = 2.1, Method: Compositional matrix adjust. Identities = 25/90 (27%), Positives = 42/90 (46%), Gaps = 4/90 (4%) Query: 115 HNAPVNEVVIHPNQGELISCDRDGN-IRIWDLGENQCTHQLTPE-DDTSLQSLSMASDGS 172 H PV V ++ + +C +DG IR++ + D TS+ + + DGS Sbjct: 178 HANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWSPDGS 237 Query: 173 MLAAANTKGNCYVWEMPNHTDASHLKPVTK 202 LA + K +V+E+ N DA + + V K Sbjct: 238 KLAVVSDKWTLHVFEVFN--DAENKRHVLK 265 >5WLC-LS nrPDB Length = 594 Score = 29.3 bits (64), Expect = 2.1, Method: Compositional matrix adjust. Identities = 32/145 (22%), Positives = 56/145 (38%), Gaps = 23/145 (15%) Query: 19 ALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNV 78 ALT + S T + D+ N KLL VRL D ++P+ A + Sbjct: 207 ALTKILSTTYNYKDTLSN-------SKLLPPKKLDIVRLKDANASHPSHSA--------I 251 Query: 79 TSVSFQQDNRWMVTSSEDGTIKVWDVRSPS---IPRNYKHNAPVNEVVIH-----PNQGE 130 S+SF ++T D T++++ + + + + +P+ + NQ Sbjct: 252 QSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFYTSLSNQNQQN 311 Query: 131 LISCDRDGNIRIWDLGENQCTHQLT 155 + + R + WDL TH T Sbjct: 312 IFTAGRRRYMHSWDLSLENLTHSQT 336 >6N8P-A nrPDB Length = 979 Score = 28.9 bits (63), Expect = 3.2, Method: Composition-based stats. Identities = 21/124 (16%), Positives = 49/124 (39%), Gaps = 13/124 (10%) Query: 79 TSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDG 138 +++ + R + + G IK++ ++ N V ++ + P Q +L++ D Sbjct: 25 SALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQENNAVTQIHLLPGQCQLVTLLDDN 84 Query: 139 NIRIWDLGENQCTHQLTPEDDTSLQSLSMA-------------SDGSMLAAANTKGNCYV 185 ++ +W L +L ++ +L+ A S +L GN +V Sbjct: 85 SLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGTESGNVFV 144 Query: 186 WEMP 189 ++P Sbjct: 145 VQLP 148 >3F3P-A nrPDB Length = 351 Score = 28.1 bits (61), Expect = 4.4, Method: Compositional matrix adjust. Identities = 22/88 (25%), Positives = 41/88 (46%), Gaps = 7/88 (7%) Query: 196 HLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDD---FKLETTLDGHQRW 252 H++P H + ++ +H+ATCS+D +V+ +D D ++L + H Sbjct: 2 HMQPFDS--GHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSS 59 Query: 253 V--WDCAFSADSAYLVTASSDHYVRLWD 278 + D A + +AS D V+LW+ Sbjct: 60 IVAIDWASPEYGRIIASASYDKTVKLWE 87 >1A3W-A nrPDB Length = 500 Score = 27.7 bits (60), Expect = 6.6, Method: Compositional matrix adjust. Identities = 14/61 (22%), Positives = 27/61 (44%), Gaps = 7/61 (11%) Query: 59 DIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAP 118 D+R P P ++ E + + F+Q + ++ S GT +P + Y+ N P Sbjct: 367 DMRNCTPKPTSTTETVAASAVAAVFEQKAKAIIVLSTSGT-------TPRLVSKYRPNCP 419 Query: 119 V 119 + Sbjct: 420 I 420 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6EMK-B nrPDB 367 e-102 5FVM-C nrPDB 355 1e-98 5WBU-D nrPDB 275 1e-74 5NNZ-B nrPDB 249 1e-66 5MZH-A nrPDB 241 2e-64 1VYH-C nrPDB 232 2e-61 6QX9-5O nrPDB 223 1e-58 6QX9-4B nrPDB 220 6e-58 5FL8-q nrPDB 217 5e-57 5M25-A nrPDB 216 9e-57 6F3T-A nrPDB 209 1e-54 3DM0-A nrPDB 208 3e-54 2H9P-A nrPDB 207 6e-54 6HQA-B nrPDB 202 2e-52 6G51-g nrPDB 199 1e-51 6MZM-G nrPDB 199 1e-51 4V6W-Ag nrPDB 199 2e-51 6HHQ-h nrPDB 194 5e-50 3JAP-g nrPDB 189 1e-48 5OQL-d nrPDB 187 4e-48 3JB9-L nrPDB 187 7e-48 5NZU-C nrPDB 186 1e-47 5OPT-p nrPDB 186 1e-47 4V8M-A7 nrPDB 184 3e-47 5WYK-BB nrPDB 182 1e-46 6EOJ-D nrPDB 180 8e-46 5Z56-q nrPDB 179 1e-45 4BTS-AR nrPDB 179 1e-45 6N9G-C nrPDB 178 2e-45 5GAN-H nrPDB 177 7e-45 5WYJ-BC nrPDB 176 1e-44 5UZ7-B nrPDB 173 1e-43 4LG8-A nrPDB 173 1e-43 4YCZ-A nrPDB 169 1e-42 6QDV-o nrPDB 169 2e-42 5YZG-W nrPDB 169 2e-42 6CHG-A nrPDB 168 3e-42 6ID0-T nrPDB 168 3e-42 3FM0-A nrPDB 166 1e-41 6Q8F-A nrPDB 166 2e-41 5WLC-LO nrPDB 164 4e-41 3MKQ-A nrPDB 163 1e-40 5L9T-R nrPDB 163 1e-40 5I2T-A nrPDB 162 2e-40 5K1B-B nrPDB 160 8e-40 2YNP-A nrPDB 158 2e-39 3JB9-g nrPDB 157 5e-39 5WLC-LU nrPDB 155 3e-38 6GMH-W nrPDB 154 4e-38 5Y88-O nrPDB 153 9e-38 5G04-R nrPDB 150 4e-37 3ODT-A nrPDB 148 2e-36 4V7E-Bg nrPDB 147 4e-36 4GGA-A nrPDB 147 4e-36 4L9O-A nrPDB 147 8e-36 3JRO-A nrPDB 146 1e-35 5LCW-Q nrPDB 145 2e-35 4J0W-A nrPDB 144 5e-35 4AEZ-A nrPDB 144 5e-35 5XYI-g nrPDB 142 1e-34 4N14-A nrPDB 140 6e-34 5WJC-A nrPDB 140 9e-34 5OV3-A nrPDB 140 1e-33 3JRP-A nrPDB 137 4e-33 6BX3-A nrPDB 137 5e-33 4BH6-A nrPDB 136 9e-33 6J6H-n nrPDB 135 2e-32 6E29-D nrPDB 134 4e-32 4BZK-B nrPDB 134 5e-32 5OQL-J nrPDB 132 3e-31 5WYJ-BE nrPDB 131 5e-31 5Y1U-A nrPDB 130 6e-31 4A11-B nrPDB 128 3e-30 4XYI-A nrPDB 128 3e-30 3C9C-A nrPDB 128 3e-30 5OQL-L nrPDB 125 1e-29 5CXC-A nrPDB 125 3e-29 6BX3-B nrPDB 124 6e-29 4U1E-I nrPDB 124 7e-29 2HES-X nrPDB 122 2e-28 4XFV-A nrPDB 120 1e-27 4OWR-A nrPDB 119 2e-27 6ELZ-p nrPDB 118 3e-27 5FA5-B nrPDB 118 4e-27 1NR0-A nrPDB 115 3e-26 5MWJ-A nrPDB 113 9e-26 5OQL-X nrPDB 107 4e-24 5N4A-A nrPDB 107 4e-24 3W15-A nrPDB 107 6e-24 5A9Q-2 nrPDB 107 7e-24 5WLC-LJ nrPDB 101 4e-22 5A9Q-0 nrPDB 98 5e-21 4E5Z-B nrPDB 97 8e-21 6EM1-m nrPDB 95 5e-20 6C0F-s nrPDB 94 1e-19 6CB1-s nrPDB 93 1e-19 6F1U-h nrPDB 89 2e-18 3ACP-A nrPDB 88 4e-18 5LTD-A nrPDB 87 1e-17 4G56-B nrPDB 82 4e-16 3JB9-S nrPDB 70 9e-13 3EI3-B nrPDB 68 6e-12 Sequences not found previously or not previously below threshold: 5A31-R nrPDB 138 3e-33 3CFV-B nrPDB 129 2e-30 3BG0-A nrPDB 120 5e-28 5K0Y-T nrPDB 111 4e-25 6CHG-D nrPDB 108 3e-24 2AQ5-A nrPDB 101 4e-22 5M89-A nrPDB 101 5e-22 2PM9-A nrPDB 99 2e-21 5WLC-SG nrPDB 97 6e-21 4J0X-A nrPDB 97 1e-20 5A9Q-7 nrPDB 93 1e-19 3JZG-A nrPDB 88 4e-18 4PSX-B nrPDB 87 6e-18 5YZG-2 nrPDB 87 7e-18 6IYY-A nrPDB 87 1e-17 2P9P-C nrPDB 87 1e-17 3F3P-A nrPDB 86 2e-17 5WLC-LN nrPDB 84 6e-17 5CXB-B nrPDB 84 6e-17 3I2N-A nrPDB 83 1e-16 5K19-A nrPDB 83 1e-16 1PI6-A nrPDB 80 8e-16 5BJS-A nrPDB 79 2e-15 5AMS-A nrPDB 77 6e-15 3DWL-C nrPDB 74 9e-14 5MC6-j nrPDB 69 3e-12 5WLC-LW nrPDB 69 3e-12 5WLC-LS nrPDB 66 2e-11 5TF2-A nrPDB 65 3e-11 3DW8-B nrPDB 64 7e-11 6N8P-A nrPDB 62 4e-10 3WJ9-A nrPDB 58 6e-09 2VDU-B nrPDB 57 8e-09 5WLC-LV nrPDB 56 2e-08 4AV8-A nrPDB 54 8e-08 5WLC-LH nrPDB 51 5e-07 2I3T-A nrPDB 51 5e-07 6CVZ-A nrPDB 51 6e-07 5K1H-B nrPDB 50 9e-07 5BPW-A nrPDB 42 3e-04 4YHC-A nrPDB 42 4e-04 5GRS-A nrPDB 41 6e-04 5BPT-A nrPDB 41 6e-04 4FHN-A nrPDB 39 0.002 6DAM-A nrPDB 37 0.007 5OLJ-A nrPDB 37 0.009 4NOX-A nrPDB 37 0.009 5WLC-LL nrPDB 37 0.011 2H47-A nrPDB 37 0.015 5CWW-B nrPDB 36 0.016 4GN8-A nrPDB 36 0.016 4IMM-A nrPDB 35 0.033 1Z68-A nrPDB 35 0.049 3FGB-A nrPDB 35 0.053 6IGB-A nrPDB 34 0.064 1RI6-A nrPDB 34 0.075 6FYY-p nrPDB 33 0.14 5SUM-A nrPDB 33 0.19 3AZQ-A nrPDB 33 0.19 4U1F-A nrPDB 32 0.33 3MWP-A nrPDB 31 0.63 2EEP-A nrPDB 30 0.89 6IGR-A nrPDB 30 0.93 1YIQ-A nrPDB 30 1.1 5JN2-A nrPDB 30 1.5 3MA6-A nrPDB 30 1.5 3HFQ-A nrPDB 29 2.0 1SM3-L nrPDB 29 2.7 4MF9-A nrPDB 29 2.9 2Z8G-A nrPDB 28 3.9 4H0U-A nrPDB 28 4.1 1Q0Y-L nrPDB 28 5.8 1OI2-A nrPDB 28 6.3 1JN6-A nrPDB 27 8.3 >6EMK-B nrPDB Length = 303 Score = 367 bits (941), Expect = e-102, Method: Composition-based stats. Identities = 303/303 (100%), Positives = 303/303 (100%) Query: 1 MSVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDI 60 MSVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDI Sbjct: 1 MSVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDI 60 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVN 120 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVN Sbjct: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVN 120 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK Sbjct: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 Query: 181 GNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDF 240 GNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDF Sbjct: 181 GNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDF 240 Query: 241 KLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVAL 300 KLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVAL Sbjct: 241 KLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVAL 300 Query: 301 NDV 303 NDV Sbjct: 301 NDV 303 >5FVM-C nrPDB Length = 303 Score = 355 bits (911), Expect = 1e-98, Method: Composition-based stats. Identities = 259/303 (85%), Positives = 287/303 (94%) Query: 1 MSVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDI 60 MSVIL SAGYDHTIRFWEALTGVCSRTIQH+DSQVNRLEIT+DKK LA AGH +VRLYDI Sbjct: 1 MSVILASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEITSDKKYLAAAGHLHVRLYDI 60 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVN 120 R+ NPNPV+SFEGH+GNVTS++FQQ+NRWMV+SSEDGTIKVWDVRSPS+ RNYKHNAPVN Sbjct: 61 RSNNPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYKHNAPVN 120 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 EV IHPNQGELISCD+DGNIRIWDLGENQCT+QLTPED+T LQSLS+ASDGSML A N K Sbjct: 121 EVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNK 180 Query: 181 GNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDF 240 GNCYVW MP+HTDAS L+PVTKF++H+ YITR+LLS+DVK+LATCSADHTARVW+I+D++ Sbjct: 181 GNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNIEDNY 240 Query: 241 KLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVAL 300 +LETTLDGHQRWVWDCAFSADSAYLVTA SDHYVRLWDLST EIVRQYGGHHKGAVCVAL Sbjct: 241 QLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLSTSEIVRQYGGHHKGAVCVAL 300 Query: 301 NDV 303 NDV Sbjct: 301 NDV 303 >5WBU-D nrPDB Length = 328 Score = 275 bits (704), Expect = 1e-74, Method: Composition-based stats. Identities = 148/312 (47%), Positives = 200/312 (64%), Gaps = 14/312 (4%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRT 62 VIL +AGYDHT+RFW+A +G+C+RT+QH DSQVN LE+T D+ ++A AG+Q++R+YD+ + Sbjct: 15 VILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNS 74 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSP--SIPRNYKHNAPVN 120 NPNP+ S++G N+ SV F +D RWM T ED T ++WD+RS R ++ NAP+N Sbjct: 75 NNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPIN 134 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 V +HPNQ ELI D+ G I IWDL + QL PE + S+ S + D S +AA N+ Sbjct: 135 CVCLHPNQAELIVGDQSGAIHIWDLKTDH-NEQLIPEPEVSITSAHIDPDASYMAAVNST 193 Query: 181 GNCYVWEMPNHT--DASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDD 238 GNCYVW + + + L P TK AH+ Y + S D LATCSAD T ++W + Sbjct: 194 GNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 253 Query: 239 DFKLETTL--------DGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGG 290 F L T L + + W+W CAFS DS Y+VTASSD+ RLW + T EI R+YGG Sbjct: 254 -FSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGG 312 Query: 291 HHKGAVCVALND 302 H K VC+A ND Sbjct: 313 HQKAVVCLAFND 324 Score = 57.4 bits (137), Expect = 8e-09, Method: Composition-based stats. Identities = 17/94 (18%), Positives = 32/94 (34%), Gaps = 11/94 (11%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQ--------HSDSQVNRLEITNDKKLLATAGHQ 53 S +L + D T + W + S + + D + + TA Sbjct: 234 STLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSD 293 Query: 54 NV-RLYDIRTTNPNPVASFEGHRGNVTSVSFQQD 86 N+ RL+ + T + GH+ V ++F Sbjct: 294 NLARLWCVETGEIK--REYGGHQKAVVCLAFNDS 325 Score = 41.2 bits (95), Expect = 5e-04, Method: Composition-based stats. Identities = 22/110 (20%), Positives = 30/110 (27%), Gaps = 42/110 (38%) Query: 217 SDVKHLATCSADHTARVWSIDDDFKLET-------------------------------- 244 SD LAT DHT R W T Sbjct: 12 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYD 71 Query: 245 ----------TLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREI 284 + DG + + F D ++ T D R+WDL +R + Sbjct: 72 LNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNL 121 Score = 29.3 bits (64), Expect = 2.0, Method: Composition-based stats. Identities = 10/42 (23%), Positives = 13/42 (30%) Query: 261 DSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 D L TA DH VR W + R + + Sbjct: 13 DPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTP 54 >5NNZ-B nrPDB Length = 415 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 69/300 (23%), Positives = 126/300 (42%), Gaps = 13/300 (4%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITND--KKLLATAGHQNVRLYDIRT 62 ++ YD T + W+ +G T++ + V + N K+ + + +L+ + T Sbjct: 107 FITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVET 166 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNE 121 +F GH + +SF + + T S D T K+WD+++ H+A + Sbjct: 167 GK--CYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIIS 224 Query: 122 VVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKG 181 + + + +I+ D + +WD + + L + S S D S++ + Sbjct: 225 LSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHC-AEISSASFNWDCSLILTGSMDK 283 Query: 182 NCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFK 241 C +W+ A++ K V H I K +AT SAD TAR++S K Sbjct: 284 TCKLWD------ATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAAT-RK 336 Query: 242 LETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 L+GH+ + +F+ +L+T SSD R+WD T + ++ GH A N Sbjct: 337 CIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFN 396 Score = 242 bits (617), Expect = 1e-64, Method: Composition-based stats. Identities = 69/276 (25%), Positives = 120/276 (43%), Gaps = 12/276 (4%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQN-VRLYDIRTT 63 + + +D T + W TG C T + +++ L L+AT +L+DI+ Sbjct: 150 IATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNG 209 Query: 64 NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSP-SIPRNYKHNAPVNEV 122 V + GH + S+SF ++T S D T+ VWD + + H A ++ Sbjct: 210 EE--VYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSA 267 Query: 123 VIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGN 182 + + +++ D ++WD +C LT DD L S G ++A A+ G Sbjct: 268 SFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSC-FDYTGKLIATASADGT 326 Query: 183 CYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKL 242 ++ A+ K + K H I++I + HL T S+D TAR+W + Sbjct: 327 ARIFS------AATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTG-QC 379 Query: 243 ETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWD 278 L+GH ++ CAF+ ++T S D+ R+W Sbjct: 380 LQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415 Score = 201 bits (511), Expect = 3e-52, Method: Composition-based stats. Identities = 57/286 (19%), Positives = 109/286 (38%), Gaps = 13/286 (4%) Query: 20 LTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRTTNPNPVASFEGHRGNV 78 T + ++ + + + T + +L+D + + + EGHR V Sbjct: 80 HTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEE--LNTLEGHRNVV 137 Query: 79 TSVSFQ-QDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQGELISCDR 136 +++F + T S D T K+W V + + H A + + +P + + Sbjct: 138 YAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSM 197 Query: 137 DGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASH 196 D ++WD+ + + L + SLS + G + + VW+ A Sbjct: 198 DTTAKLWDIQNGEEVYTLRGHS-AEIISLSFNTSGDRIITGSFDHTVVVWD------ADT 250 Query: 197 LKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDC 256 + V H I+ + D + T S D T ++W + K TL GH + D Sbjct: 251 GRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNG-KCVATLTGHDDEILDS 309 Query: 257 AFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 F + TAS+D R++ +TR+ + + GH ++ N Sbjct: 310 CFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNP 355 Score = 172 bits (437), Expect = 1e-43, Method: Composition-based stats. Identities = 44/235 (18%), Positives = 89/235 (37%), Gaps = 11/235 (4%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDK-KLLATAGHQNVRLYDI 60 S ++ + D T + W+ G T++ +++ L +++ + V ++D Sbjct: 189 STLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDA 248 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPV 119 T V GH ++S SF D ++T S D T K+WD + H+ + Sbjct: 249 DTGRK--VNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEI 306 Query: 120 NEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANT 179 + + + DG RI+ +C +L + + +S G+ L ++ Sbjct: 307 LDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEG-EISKISFNPQGNHLLTGSS 365 Query: 180 KGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVW 234 +W+ A + + H+ I + + T S D+T R+W Sbjct: 366 DKTARIWD------AQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414 >5MZH-A nrPDB Length = 452 Score = 241 bits (616), Expect = 2e-64, Method: Composition-based stats. Identities = 66/300 (22%), Positives = 128/300 (42%), Gaps = 13/300 (4%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITND--KKLLATAGHQNVRLYDIRT 62 ++ YD T + W TG T++ + V + N K++ + + +L+D T Sbjct: 109 FITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYT 168 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNE 121 + +GH+ + +SF + + T S D T K+WDV + H A + Sbjct: 169 GQ--LYYTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETGQERATLAGHRAEIVS 226 Query: 122 VVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKG 181 + + +++ D + R+WD+ QC H L+ + S G+++ + + Sbjct: 227 LGFNTGGDLIVTGSFDHDSRLWDVRTGQCVHVLSGHRG-EVSSTQFNYAGTLVVSGSIDC 285 Query: 182 NCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFK 241 +W++ + + ++ + H+ + + + + + SAD +AR++ Sbjct: 286 TSRLWDVRSG------RCLSVKQGHTDEVLDVAFDAAGTKMVSASADGSARLYHTLTGV- 338 Query: 242 LETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 + TL GH+ + AF+ L+TASSD RLWD T E ++ GH A N Sbjct: 339 CQHTLVGHEGEISKVAFNPQGTRLITASSDKTCRLWDCDTGECLQVLEGHTDEIFSCAFN 398 Score = 234 bits (596), Expect = 4e-62, Method: Composition-based stats. Identities = 62/275 (22%), Positives = 119/275 (43%), Gaps = 12/275 (4%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRTT 63 +V+ +D T + W+A TG T++ +++ L ++AT +L+D+ T Sbjct: 152 IVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETG 211 Query: 64 NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEV 122 A+ GHR + S+ F +VT S D ++WDVR+ H V+ Sbjct: 212 QER--ATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQCVHVLSGHRGEVSST 269 Query: 123 VIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGN 182 + ++S D R+WD+ +C D + ++ + G+ + +A+ G+ Sbjct: 270 QFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTD-EVLDVAFDAAGTKMVSASADGS 328 Query: 183 CYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKL 242 ++ H I+++ + L T S+D T R+W D L Sbjct: 329 ARLYHTL------TGVCQHTLVGHEGEISKVAFNPQGTRLITASSDKTCRLWDCDTGECL 382 Query: 243 ETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 + L+GH ++ CAF+ + +++T S D+ R+W Sbjct: 383 Q-VLEGHTDEIFSCAFNYEGDFIITGSKDNTCRIW 416 Score = 184 bits (466), Expect = 6e-47, Method: Composition-based stats. Identities = 56/243 (23%), Positives = 98/243 (40%), Gaps = 11/243 (4%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDI 60 S I+ + D+T + W+ TG T+ +++ L L+ T + RL+D+ Sbjct: 191 STIIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDV 250 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPR-NYKHNAPV 119 RT V GHRG V+S F +V+ S D T ++WDVRS H V Sbjct: 251 RTGQ--CVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDEV 308 Query: 120 NEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANT 179 +V +++S DG+ R++ C H L + + ++ G+ L A++ Sbjct: 309 LDVAFDAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEG-EISKVAFNPQGTRLITASS 367 Query: 180 KGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDD 239 C +W+ + + H+ I + + + T S D+T R+W Sbjct: 368 DKTCRLWDCD------TGECLQVLEGHTDEIFSCAFNYEGDFIITGSKDNTCRIWKALTA 421 Query: 240 FKL 242 Sbjct: 422 SSQ 424 Score = 147 bits (371), Expect = 5e-36, Method: Composition-based stats. Identities = 39/187 (20%), Positives = 69/187 (36%), Gaps = 7/187 (3%) Query: 115 HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSML 174 H P+ + + I+ D ++W+ + L + G + Sbjct: 93 HILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFNNPYGDKI 152 Query: 175 AAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVW 234 + C +W+ A + + H T I + + +AT S D+TA++W Sbjct: 153 VTGSFDKTCKLWD------AYTGQLYYTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLW 206 Query: 235 SIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKG 294 ++ + TL GH+ + F+ +VT S DH RLWD+ T + V GH Sbjct: 207 DVETGQER-ATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQCVHVLSGHRGE 265 Query: 295 AVCVALN 301 N Sbjct: 266 VSSTQFN 272 Score = 95.9 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 30/120 (25%), Positives = 48/120 (40%), Gaps = 2/120 (1%) Query: 184 YVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLE 243 + + RAH +T + T S D T +VW+ ++ Sbjct: 71 RLIDKMLEQQHHSFTLFKVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVF 130 Query: 244 TTLDGHQRWVWDCAFS-ADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 TL+GH+ V+ AF+ +VT S D +LWD T ++ GH VC++ N Sbjct: 131 -TLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSFNP 189 >1VYH-C nrPDB Length = 410 Score = 232 bits (591), Expect = 2e-61, Method: Composition-based stats. Identities = 71/299 (23%), Positives = 131/299 (43%), Gaps = 32/299 (10%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRT 62 ++VSA D TI+ W+ TG RT++ V + + KLLA+ ++L+D + Sbjct: 122 VMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQG 181 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNE 121 + + GH NV+SVS + +V++S D TIK+W+V++ + + H V Sbjct: 182 FE--CIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRM 239 Query: 122 VVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASD----------- 170 V + + + SC D +R+W + +C +L ++ +S A + Sbjct: 240 VRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHRHV-VECISWAPESSYSSISEATG 298 Query: 171 ---------GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKH 221 G L + + +W++ S + H ++ +L S K Sbjct: 299 SETKKSGKPGPFLLSGSRDKTIKMWDV------STGMCLMTLVGHDNWVRGVLFHSGGKF 352 Query: 222 LATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLS 280 + +C+ D T RVW + + TL+ H+ +V F + Y+VT S D V++W+ Sbjct: 353 ILSCADDKTLRVWDYKNK-RCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410 Score = 198 bits (504), Expect = 2e-51, Method: Composition-based stats. Identities = 58/297 (19%), Positives = 120/297 (40%), Gaps = 32/297 (10%) Query: 28 IQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQD 86 + S V R+ ++ +A ++++D T + + +GH +V +SF Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFE--RTLKGHTDSVQDISFDHS 161 Query: 87 NRWMVTSSEDGTIKVWDVRSPSIPRN-YKHNAPVNEVVIHPNQGELISCDRDGNIRIWDL 145 + + + S D TIK+WD + R + H+ V+ V I PN ++S RD I++W++ Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWEV 221 Query: 146 GENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRA 205 C T + ++ + DG+++A+ + VW + + + + R Sbjct: 222 QTGYCVKTFTGHREW-VRMVRPNQDGTLIASCSNDQTVRVWVV------ATKECKAELRE 274 Query: 206 HSTYITRILLSSDVKH--------------------LATCSADHTARVWSIDDDFKLETT 245 H + I + + + L + S D T ++W + L T Sbjct: 275 HRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLM-T 333 Query: 246 LDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 L GH WV F + ++++ + D +R+WD + ++ H + + Sbjct: 334 LVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHK 390 Score = 112 bits (280), Expect = 2e-25, Method: Composition-based stats. Identities = 26/166 (15%), Positives = 63/166 (37%), Gaps = 24/166 (14%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKL---------------- 46 ++ S D T+R W T C ++ V + + Sbjct: 247 TLIASCSNDQTVRVWVVATKECKAELREHRHVVECISWAPESSYSSISEATGSETKKSGK 306 Query: 47 -----LATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKV 101 L+ + + ++++D+ T + + GH V V F +++++ ++D T++V Sbjct: 307 PGPFLLSGSRDKTIKMWDVSTG--MCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRV 364 Query: 102 WDVRSPSIPRNY-KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLG 146 WD ++ + H V + H +++ D +++W+ Sbjct: 365 WDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410 Score = 96.3 bits (238), Expect = 1e-20, Method: Composition-based stats. Identities = 27/102 (26%), Positives = 43/102 (42%), Gaps = 1/102 (0%) Query: 199 PVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAF 258 H + +TR++ + + S D T +VW + E TL GH V D +F Sbjct: 100 EKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETG-DFERTLKGHTDSVQDISF 158 Query: 259 SADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVAL 300 L + S+D ++LWD E +R GH V++ Sbjct: 159 DHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSI 200 >6QX9-5O nrPDB Length = 357 Score = 223 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 74/282 (26%), Positives = 127/282 (45%), Gaps = 11/282 (3%) Query: 5 LVSAGYDHTIRFWEALTGVC--SRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIR 61 L SAG+D I W G C T++ V L D +L +A + V ++D Sbjct: 81 LASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSE 139 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMV-TSSEDGTIKVWDVRSPSIPRNYKHNAPVN 120 T V +GH V S + +V T S+DGT+K+WD+R + + +++ V Sbjct: 140 TGER--VKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVL 197 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 V + ++IS D +I++WDL +N+ T+ + D S+ LS++S+GS L + Sbjct: 198 AVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHAD-SVTGLSLSSEGSYLLSNAMD 256 Query: 181 GNCYVWEMPNHTDASHLKPVTKFRAHSTY--ITRILLSSDVKHLATCSADHTARVWSIDD 238 VW++ + + H+ + R S D +A SAD VW Sbjct: 257 NTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWD-TT 315 Query: 239 DFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLS 280 ++ L GH + + AF D +++ASSD + + ++ Sbjct: 316 SRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357 Score = 194 bits (493), Expect = 4e-50, Method: Composition-based stats. Identities = 57/285 (20%), Positives = 124/285 (43%), Gaps = 19/285 (6%) Query: 28 IQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQD 86 + + +V + + LA+AG + + L+++ + + A+ +GH G V + + D Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNV-YGDCDNYATLKGHSGAVMELHYNTD 120 Query: 87 NRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGEL-ISCDRDGNIRIWD 144 + ++S D T+ VWD + + K H + VN +L + DG +++WD Sbjct: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180 Query: 145 LGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFR 204 + + ++ + +++ + + + VW++ K R Sbjct: 181 IRKKAAIQTF--QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDL------RQNKLTYTMR 232 Query: 205 AHSTYITRILLSSDVKHLATCSADHTARVWSID---DDFKLETTLDG----HQRWVWDCA 257 H+ +T + LSS+ +L + + D+T RVW + + G ++ + C+ Sbjct: 233 GHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCS 292 Query: 258 FSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 +S D + + S+D +V +WD ++R I+ + GH VA + Sbjct: 293 WSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHP 337 Score = 160 bits (404), Expect = 7e-40, Method: Composition-based stats. Identities = 53/240 (22%), Positives = 96/240 (40%), Gaps = 19/240 (7%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLAT--AGHQNVRLYDIR 61 +L SA D T+ W++ TG + ++ S VN L + V+L+DIR Sbjct: 123 MLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIR 182 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVN 120 + +F+ V +V+F + +++ D IKVWD+R + H V Sbjct: 183 --KKAAIQTFQN-TYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVT 239 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLG----ENQCTHQLTPEDDT---SLQSLSMASDGSM 173 + + L+S D +R+WD+ + +C +L S + DGS Sbjct: 240 GLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSK 299 Query: 174 LAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARV 233 +AA + YVW+ + + + K H+ I + D + + S+D + Sbjct: 300 IAAGSADRFVYVWDTTSR------RILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYM 353 Score = 96.3 bits (238), Expect = 1e-20, Method: Composition-based stats. Identities = 25/102 (24%), Positives = 41/102 (40%) Query: 197 LKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDC 256 P+ H + + LA+ D +W++ D TL GH V + Sbjct: 56 QAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMEL 115 Query: 257 AFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCV 298 ++ D + L +AS+D V +WD T E V++ GH Sbjct: 116 HYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSC 157 >6QX9-4B nrPDB Length = 522 Score = 220 bits (560), Expect = 6e-58, Method: Composition-based stats. Identities = 62/287 (21%), Positives = 115/287 (40%), Gaps = 21/287 (7%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITN---------DKKLLATAGH 52 S +L +A + + W T++ ++ V + D L + A Sbjct: 243 SKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAAD 302 Query: 53 QNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS-IPR 111 +V+L+ + + PVA EGH V V + R++ T+ D + ++WD+ + I Sbjct: 303 GSVKLWSLDSDE--PVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILH 360 Query: 112 NYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDG 171 H+ V ++ H + + D R+WDL +C L + ++ + +G Sbjct: 361 QEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLK-EIYGINFSPNG 419 Query: 172 SMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSS-DVKHLATCSADHT 230 +A + C VW++ + V AH +T + L T + D+T Sbjct: 420 YHIATGSGDNTCKVWDL------RQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNT 473 Query: 231 ARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 A++W+ + TL GH+ V S+D + T S D +LW Sbjct: 474 AKIWTH-PGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519 Score = 173 bits (439), Expect = 7e-44, Method: Composition-based stats. Identities = 57/283 (20%), Positives = 112/283 (39%), Gaps = 21/283 (7%) Query: 30 HSDSQVNRLEITNDKKLLATA-GHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNR 88 D ++ + + K+LATA +L+ + + N + + GH NV ++ F + Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVP--DCNLLHTLRGHNTNVGAIVFHPKST 286 Query: 89 W--------MVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQGELISCDRDGN 139 + + + DG++K+W + S + H V V+ HP+ L + D + Sbjct: 287 VSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRS 346 Query: 140 IRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKP 199 R+WDL + + ++ DGS+ VW++ + Sbjct: 347 WRLWDLEAQEEILHQEGHS-MGVYDIAFHQDGSLAGTGGLDAFGRVWDL------RTGRC 399 Query: 200 VTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFS 259 + H I I S + H+AT S D+T +VW + + T+ HQ V F Sbjct: 400 IMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQ-RRCVYTIPAHQNLVTGVKFE 458 Query: 260 A-DSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 +L+T + D+ ++W ++ GH + + ++ Sbjct: 459 PIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDIS 501 Score = 164 bits (415), Expect = 4e-41, Method: Composition-based stats. Identities = 48/240 (20%), Positives = 88/240 (36%), Gaps = 17/240 (7%) Query: 73 GHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQG-- 129 G ++ F +++ + T+ G K+W V ++ HN V +V HP Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288 Query: 130 ------ELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNC 183 L SC DG++++W L ++ + + + G L + Sbjct: 289 LDPKDVNLASCAADGSVKLWSLDSDEPVADIEGH-TVRVARVMWHPSGRFLGTTCYDRSW 347 Query: 184 YVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLE 243 +W++ + H + HS + I D T D RVW + + Sbjct: 348 RLWDLEAQEEILHQE------GHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTG-RCI 400 Query: 244 TTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALNDV 303 L+GH + ++ FS + ++ T S D+ ++WDL R V H V + Sbjct: 401 MFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPI 460 Score = 130 bits (326), Expect = 1e-30, Method: Composition-based stats. Identities = 39/198 (19%), Positives = 76/198 (38%), Gaps = 14/198 (7%) Query: 112 NYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSL-------QS 164 + P++ PN L + G ++W + + H L + + Sbjct: 227 QIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKST 286 Query: 165 LSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLAT 224 +S+ LA+ G+ +W + + +PV H+ + R++ + L T Sbjct: 287 VSLDPKDVNLASCAADGSVKLWSLDSD------EPVADIEGHTVRVARVMWHPSGRFLGT 340 Query: 225 CSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREI 284 D + R+W ++ ++ +GH V+D AF D + T D + R+WDL T Sbjct: 341 TCYDRSWRLWDLEAQEEILH-QEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRC 399 Query: 285 VRQYGGHHKGAVCVALND 302 + GH K + + Sbjct: 400 IMFLEGHLKEIYGINFSP 417 >5FL8-q nrPDB Length = 515 Score = 217 bits (553), Expect = 5e-57, Method: Composition-based stats. Identities = 77/348 (22%), Positives = 138/348 (39%), Gaps = 56/348 (16%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDI 60 S +V+ D+T R W+ T T++ + V + + D +++AT +RL+D Sbjct: 156 SSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDP 215 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQ-------DNRWMVTSSEDGTIKVWDVRSPSIPRNY 113 ++ A GH +TS+S++ + +SS+DGTIK+WD S Sbjct: 216 KSGQCLGDA-LRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTM 274 Query: 114 -KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASD-- 170 H V+ V QG L S D +R+WD+ + + LS+++D Sbjct: 275 SGHTNSVSCVKW-GGQGLLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSLSTDYA 333 Query: 171 -------------------------------------GSMLAAANTKGNCYVWEMPNHTD 193 M+ A+ ++W T Sbjct: 334 LRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNPLKST- 392 Query: 194 ASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWV 253 KP+ + H + + S D +++ + S D++ ++W D K +T GH V Sbjct: 393 ----KPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGRDG-KFISTFRGHVASV 447 Query: 254 WDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 + A+S+D LV+ S D +++WD+ TR++ GH V + Sbjct: 448 YQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDLPGHKDEVYTVDWS 495 Score = 180 bits (456), Expect = 9e-46, Method: Composition-based stats. Identities = 69/327 (21%), Positives = 128/327 (39%), Gaps = 59/327 (18%) Query: 25 SRTIQHSDSQVNRLEITN--DKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVS 82 S I S + +++ AG R++D T P+ + +GH V VS Sbjct: 136 SSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDT--QTPMHTLKGHYNWVLCVS 193 Query: 83 FQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY--KHNAPVNEVVIHP-------NQGELIS 133 + D + T S D TI++WD +S + H+ + + P ++ L S Sbjct: 194 WSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLAS 253 Query: 134 CDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTD 193 +DG I+IWD C + ++ + S+ + G +L + + VW++ + Sbjct: 254 SSKDGTIKIWDTVSRVCQYTMSGHTN-SVSCVKWGGQG-LLYSGSHDRTVRVWDINS--- 308 Query: 194 ASHLKPVTKFRAHSTYITRILLSSD----------------------------------- 218 + + ++H+ ++ + LS+D Sbjct: 309 --QGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKK 366 Query: 219 ----VKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYV 274 + + T S D+T +W+ K + GHQ+ V AFS D Y+V+AS D+ + Sbjct: 367 NGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSI 426 Query: 275 RLWDLSTREIVRQYGGHHKGAVCVALN 301 +LWD + + + GH VA + Sbjct: 427 KLWDGRDGKFISTFRGHVASVYQVAWS 453 Score = 174 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 59/324 (18%), Positives = 123/324 (37%), Gaps = 60/324 (18%) Query: 4 ILVSAGYDHTIRFWEALTGVCS-RTIQHSDSQVNRLEITN--------DKKLLATAGHQN 54 ++ + D+TIR W+ +G C ++ + L +L +++ Sbjct: 200 VIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGT 259 Query: 55 VRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSP--SIPRN 112 ++++D T + + GH +V+ V + + + S D T++VWD+ S I Sbjct: 260 IKIWD--TVSRVCQYTMSGHTNSVSCVKWGGQG-LLYSGSHDRTVRVWDINSQGRCINIL 316 Query: 113 YKHNAPVNEVVIHPN---------------------------------------QGELIS 133 H VN + + + + +++ Sbjct: 317 KSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVT 376 Query: 134 CDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTD 193 D + +W+ ++ + ++ + DG + +A+ + +W+ + Sbjct: 377 ASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGRDG-- 434 Query: 194 ASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWV 253 K ++ FR H + ++ SSD + L +CS D T +VW + KL L GH+ V Sbjct: 435 ----KFISTFRGHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRT-RKLSVDLPGHKDEV 489 Query: 254 WDCAFSADSAYLVTASSDHYVRLW 277 + +S D + + D VRLW Sbjct: 490 YTVDWSVDGKRVCSGGKDKMVRLW 513 Score = 96.3 bits (238), Expect = 1e-20, Method: Composition-based stats. Identities = 22/101 (21%), Positives = 51/101 (50%), Gaps = 3/101 (2%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIR 61 +VSA +D++I+ W+ G T + + V ++ ++D +LL + ++++D+R Sbjct: 415 RYIVSASFDNSIKLWDGRDGKFISTFRGHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVR 474 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW 102 T GH+ V +V + D + + + +D +++W Sbjct: 475 TRK--LSVDLPGHKDEVYTVDWSVDGKRVCSGGKDKMVRLW 513 Score = 53.1 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 17/71 (23%), Positives = 35/71 (49%), Gaps = 1/71 (1%) Query: 233 VWSIDDDFKLETTLDGHQRWVWDCAFSA-DSAYLVTASSDHYVRLWDLSTREIVRQYGGH 291 V+ + + + + GH + AF+ S+ +VT + D+ R+WD T+ + GH Sbjct: 126 VFKVKPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGH 185 Query: 292 HKGAVCVALND 302 + +CV+ + Sbjct: 186 YNWVLCVSWSP 196 >5M25-A nrPDB Length = 434 Score = 216 bits (550), Expect = 9e-57, Method: Composition-based stats. Identities = 59/280 (21%), Positives = 121/280 (43%), Gaps = 16/280 (5%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQ-NVRLYDIRTT 63 L S+ D I+ W A G +TI ++ + ++D LL +A ++++D+ + Sbjct: 160 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG 219 Query: 64 NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEV 122 + + +GH V +F + +V+ S D ++++WDV++ + H+ PV+ V Sbjct: 220 K--CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAV 277 Query: 123 VIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGN 182 + + ++S DG RIWD QC L +D+ + + + +G + AA Sbjct: 278 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT 337 Query: 183 CYVWEMPNHTDASHLKPVTKFRAHSTYITRILLS---SDVKHLATCSADHTARVWSIDDD 239 +W+ K + + H I + + K + + S D+ +W++ Sbjct: 338 LKLWDYSKG------KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK 391 Query: 240 FKLETTLDGHQRWVWDCAFSADSAYLVTAS--SDHYVRLW 277 ++ L GH V A + +A+ +D ++LW Sbjct: 392 -EIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 430 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 61/282 (21%), Positives = 133/282 (47%), Gaps = 16/282 (5%) Query: 27 TIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQ 85 T+ V+ ++ + + + LA++ + ++++ + GH+ ++ V++ Sbjct: 140 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE--KTISGHKLGISDVAWSS 197 Query: 86 DNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDGNIRIWD 144 D+ +V++S+D T+K+WDV S + K H+ V +P ++S D ++RIWD Sbjct: 198 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 257 Query: 145 LGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFR 204 + +C L D + ++ DGS++ +++ G C +W+ + L Sbjct: 258 VKTGKCLKTLPAHSD-PVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL-----ID 311 Query: 205 AHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSA---- 260 + ++ + S + K++ + D+T ++W K T GH+ + C F+ Sbjct: 312 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG-KCLKTYTGHKNEKY-CIFANFSVT 369 Query: 261 DSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 ++V+ S D+ V +W+L T+EIV++ GH + A + Sbjct: 370 GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 411 Score = 186 bits (472), Expect = 1e-47, Method: Composition-based stats. Identities = 51/243 (20%), Positives = 105/243 (43%), Gaps = 15/243 (6%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDI 60 S +LVSA D T++ W+ +G C +T++ + V L+ + ++VR++D+ Sbjct: 199 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 258 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNA--P 118 +T + + H V++V F +D +V+SS DG ++WD S + + P Sbjct: 259 KTGK--CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 316 Query: 119 VNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSM--ASDGSMLAA 176 V+ V PN +++ D +++WD + +C T + + + G + + Sbjct: 317 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 376 Query: 177 ANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCS--ADHTARVW 234 + Y+W + + V K + H+ + +A+ + D T ++W Sbjct: 377 GSEDNLVYIWNL------QTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 430 Query: 235 SID 237 D Sbjct: 431 KSD 433 Score = 124 bits (312), Expect = 3e-29, Method: Composition-based stats. Identities = 38/157 (24%), Positives = 64/157 (40%), Gaps = 7/157 (4%) Query: 145 LGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFR 204 + N ++ S+ + +G LA+++ +W A K Sbjct: 131 VKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG------AYDGKFEKTIS 184 Query: 205 AHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAY 264 H I+ + SSD L + S D T ++W + K TL GH +V+ C F+ S Sbjct: 185 GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG-KCLKTLKGHSNYVFCCNFNPQSNL 243 Query: 265 LVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 +V+ S D VR+WD+ T + ++ H V N Sbjct: 244 IVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 280 Score = 112 bits (280), Expect = 2e-25, Method: Composition-based stats. Identities = 31/108 (28%), Positives = 55/108 (50%), Gaps = 1/108 (0%) Query: 195 SHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVW 254 + H+ ++ + S + + LA+ SAD ++W D K E T+ GH+ + Sbjct: 133 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG-KFEKTISGHKLGIS 191 Query: 255 DCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 D A+S+DS LV+AS D +++WD+S+ + ++ GH C N Sbjct: 192 DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP 239 >6F3T-A nrPDB Length = 608 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 67/279 (24%), Positives = 111/279 (39%), Gaps = 23/279 (8%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNV-RLYDI 60 S ++ D T+R W T R+++ + +D L+ + R+ D Sbjct: 290 SSLIAGGFADSTVRVWSV-TPKKLRSVKQA----------SDLSLIDKESDDVLERIMDE 338 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPV 119 +T + + GH G V SF D ++++SSEDGT+++W +++ + YK HN PV Sbjct: 339 KTASELKI--LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPV 396 Query: 120 NEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANT 179 + P +S D R+W Q + + + +A + Sbjct: 397 WDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHL-ADVNCTRFHPNSNYVATGSA 455 Query: 180 KGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDD 239 +W++ N V F H I + S + + LAT + D +W I Sbjct: 456 DRTVRLWDVLNGN------CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHG 509 Query: 240 FKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWD 278 + L GH V FS D L + S D+ VRLWD Sbjct: 510 L-MVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 547 Score = 186 bits (473), Expect = 9e-48, Method: Composition-based stats. Identities = 55/245 (22%), Positives = 97/245 (39%), Gaps = 23/245 (9%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNV-RLYDIR 61 L+S+ D T+R W T C + + V + + + GH V RL+ Sbjct: 364 NYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLW--A 421 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVN 120 T + P+ F GH +V F ++ ++ T S D T+++WDV + + R + H P++ Sbjct: 422 TDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIH 481 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 + PN L + DG + +WD+G +L DT + SL + DG +LA+ + Sbjct: 482 SLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDT-VCSLRFSRDGEILASGSMD 540 Query: 181 GNCYVWEMPNHTDASHLKPVTKFRAH------------------STYITRILLSSDVKHL 222 +W+ + T H ST + + + L Sbjct: 541 NTVRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVVHLHFTRRNLVL 600 Query: 223 ATCSA 227 A + Sbjct: 601 AAGAY 605 Score = 186 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 56/248 (22%), Positives = 96/248 (38%), Gaps = 16/248 (6%) Query: 9 GYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRTTNPNP 67 D R + T + + V + D+ L ++ VRL+ ++T Sbjct: 328 SDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTF--TC 385 Query: 68 VASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHP 126 + ++GH V F + V+ D ++W R + H A VN HP Sbjct: 386 LVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHP 445 Query: 127 NQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVW 186 N + + D +R+WD+ C T + SL+ + +G LA T G +W Sbjct: 446 NSNYVATGSADRTVRLWDVLNGNCVRIFTGHKG-PIHSLTFSPNGRFLATGATDGRVLLW 504 Query: 187 EMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLE--- 243 ++ H V + + H+ + + S D + LA+ S D+T R+W F+ Sbjct: 505 DI------GHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETD 558 Query: 244 --TTLDGH 249 TT GH Sbjct: 559 DFTTATGH 566 Score = 182 bits (461), Expect = 2e-46, Method: Composition-based stats. Identities = 57/286 (19%), Positives = 108/286 (37%), Gaps = 23/286 (8%) Query: 18 EALTGVCSRTIQHSDSQVNRLEITNDKKLLATA-GHQNVRLYDIRTTNPNPVASFEGHRG 76 + L +C T ++ + +++T+D L+A VR++ + Sbjct: 264 DCLPSICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLR---------- 313 Query: 77 NVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPR-NYKHNAPVNEVVIHPNQGELISCD 135 SV D + S+D ++ D ++ S + Y H+ PV P++ L+S Sbjct: 314 ---SVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSS 370 Query: 136 RDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDAS 195 DG +R+W L C + + + G + +W Sbjct: 371 EDGTVRLWSLQTFTCLVGYKGH-NYPVWDTQFSPYGYYFVSGGHDRVARLWATD------ 423 Query: 196 HLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWD 255 H +P+ F H + + ++AT SAD T R+W + + GH+ + Sbjct: 424 HYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNG-NCVRIFTGHKGPIHS 482 Query: 256 CAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 FS + +L T ++D V LWD+ +V + GH + + Sbjct: 483 LTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS 528 Score = 138 bits (348), Expect = 2e-33, Method: Composition-based stats. Identities = 45/236 (19%), Positives = 80/236 (33%), Gaps = 18/236 (7%) Query: 67 PVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHP 126 +F +T+V D+ + D T++VW V + V Sbjct: 270 CFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKL----------RSVKQAS 319 Query: 127 NQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVW 186 + + D RI D L + S + D + L +++ G +W Sbjct: 320 DLSLIDKESDDVLERIMDEKTASELKILYGHSG-PVYGASFSPDRNYLLSSSEDGTVRLW 378 Query: 187 EMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTL 246 + + ++ H+ + S + + D AR+W D ++ Sbjct: 379 SL------QTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLW-ATDHYQPLRIF 431 Query: 247 DGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 GH V F +S Y+ T S+D VRLWD+ VR + GH + + Sbjct: 432 AGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSP 487 >3DM0-A nrPDB Length = 694 Score = 208 bits (528), Expect = 3e-54, Method: Composition-based stats. Identities = 64/308 (20%), Positives = 128/308 (41%), Gaps = 43/308 (13%) Query: 4 ILVSAGYDHTIRFW-----EALTGVCSRTIQHSDSQVNRLEITNDKKL-LATAGHQNVRL 57 I+VSA D +I W + GV R + V + +++D + L+ + +RL Sbjct: 397 IIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVLSSDGQFALSGSWDGELRL 456 Query: 58 YDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY---- 113 +D+ F GH +V SV+F DNR +V++S D TIK+W+ Sbjct: 457 WDLAAG--VSTRRFVGHTKDVLSVAFSLDNRQIVSASRDRTIKLWNTL-GECKYTISEGG 513 Query: 114 -KHNAPVNEVVIHPN--QGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASD 170 H V+ V PN Q ++S D +++W+L + L + +++++ D Sbjct: 514 EGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCKLRSTLAGHTGY-VSTVAVSPD 572 Query: 171 GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHT 230 GS+ A+ G +W++ L+ + + L S ++ + +H Sbjct: 573 GSLCASGGKDGVVLLWDLAEGKKLYSLE--------ANSVIHALCFSPNRYWLCAATEHG 624 Query: 231 ARVWSID-----DDFKLETTLDGHQR-------------WVWDCAFSADSAYLVTASSDH 272 ++W ++ +D K++ + + + +SAD + L + +D Sbjct: 625 IKIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKVIYCTSLNWSADGSTLFSGYTDG 684 Query: 273 YVRLWDLS 280 +R+W + Sbjct: 685 VIRVWGIG 692 Score = 164 bits (415), Expect = 5e-41, Method: Composition-based stats. Identities = 50/274 (18%), Positives = 116/274 (42%), Gaps = 21/274 (7%) Query: 27 TIQHSDSQVNRLEITNDKK--LLATAGHQNVRLYDIRTTNP---NPVASFEGHRGNVTSV 81 T++ V + D +++ + +++ L+ + + GH V V Sbjct: 377 TMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDV 436 Query: 82 SFQQDNRWMVTSSEDGTIKVWDVRSP-SIPRNYKHNAPVNEVVIHPNQGELISCDRDGNI 140 D ++ ++ S DG +++WD+ + S R H V V + +++S RD I Sbjct: 437 VLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSASRDRTI 496 Query: 141 RIWDLGENQCTHQLTPEDDTS---LQSLSMASDG--SMLAAANTKGNCYVWEMPNHTDAS 195 ++W+ +C + ++ + + + + + + +A+ VW + S Sbjct: 497 KLWNTL-GECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNL------S 549 Query: 196 HLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWD 255 + K + H+ Y++ + +S D A+ D +W + + KL +L+ + Sbjct: 550 NCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKL-YSLEA-NSVIHA 607 Query: 256 CAFSADSAYLVTASSDHYVRLWDLSTREIVRQYG 289 FS + Y + A+++H +++WDL ++ IV Sbjct: 608 LCFSPN-RYWLCAATEHGIKIWDLESKSIVEDLK 640 Score = 150 bits (380), Expect = 5e-37, Method: Composition-based stats. Identities = 51/242 (21%), Positives = 99/242 (40%), Gaps = 15/242 (6%) Query: 70 SFEGHRGNVTSVSFQ-QDNRWMVTSSEDGTIKVWDVRSPSI------PRNYKHNAPVNEV 122 + H VT+++ + +V++S D +I +W + R H+ V +V Sbjct: 377 TMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDV 436 Query: 123 VIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGN 182 V+ + +S DG +R+WDL T + + S++ + D + +A+ Sbjct: 437 VLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTK-DVLSVAFSLDNRQIVSASRDRT 495 Query: 183 CYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDV--KHLATCSADHTARVWSIDDDF 240 +W H +++ + S + + + S D T +VW++ + Sbjct: 496 IKLWNTLGECK---YTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSN-C 551 Query: 241 KLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHH-KGAVCVA 299 KL +TL GH +V A S D + + D V LWDL+ + + + A+C + Sbjct: 552 KLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEANSVIHALCFS 611 Query: 300 LN 301 N Sbjct: 612 PN 613 Score = 131 bits (330), Expect = 4e-31, Method: Composition-based stats. Identities = 43/198 (21%), Positives = 82/198 (41%), Gaps = 17/198 (8%) Query: 115 HNAPVNEVVI-HPNQGELISCDRDGNIRIW-----DLGENQCTHQLTPEDDTSLQSLSMA 168 H V + N ++S RD +I +W D +LT ++ + ++ Sbjct: 381 HTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHF-VEDVVLS 439 Query: 169 SDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSAD 228 SDG + + G +W++ F H+ + + S D + + + S D Sbjct: 440 SDGQFALSGSWDGELRLWDLAAGVSTRR------FVGHTKDVLSVAFSLDNRQIVSASRD 493 Query: 229 HTARVWSIDDDFK--LETTLDGHQRWVWDCAFSAD--SAYLVTASSDHYVRLWDLSTREI 284 T ++W+ + K + +GH+ WV FS + +V+AS D V++W+LS ++ Sbjct: 494 RTIKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCKL 553 Query: 285 VRQYGGHHKGAVCVALND 302 GH VA++ Sbjct: 554 RSTLAGHTGYVSTVAVSP 571 Score = 109 bits (272), Expect = 2e-24, Method: Composition-based stats. Identities = 32/154 (20%), Positives = 62/154 (40%), Gaps = 7/154 (4%) Query: 153 QLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITR 212 + D + + ++ +A+ + +W++ A + + HS ++ Sbjct: 377 TMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQ-RRLTGHSHFVED 435 Query: 213 ILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDH 272 ++LSSD + + S D R+W + GH + V AFS D+ +V+AS D Sbjct: 436 VVLSSDGQFALSGSWDGELRLWDLAAGVSTRR-FVGHTKDVLSVAFSLDNRQIVSASRDR 494 Query: 273 YVRLWDLSTREIVRQY----GGHHKGAVCVALND 302 ++LW+ + E GH CV + Sbjct: 495 TIKLWN-TLGECKYTISEGGEGHRDWVSCVRFSP 527 Score = 99.8 bits (247), Expect = 1e-21, Method: Composition-based stats. Identities = 40/189 (21%), Positives = 73/189 (38%), Gaps = 28/189 (14%) Query: 1 MSVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYD 59 + +VSA +D T++ W T+ V+ + ++ D L A+ G V L+D Sbjct: 530 LQPTIVSASWDKTVKVWNLSNCKLRSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWD 589 Query: 60 IRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPV 119 + + S E + ++ F + W+ ++E G IK+WD+ S SI + K + Sbjct: 590 L--AEGKKLYSLEA-NSVIHALCFSPNRYWLCAATEHG-IKIWDLESKSIVEDLKVD--- 642 Query: 120 NEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANT 179 ++ + T SL+ ++DGS L + T Sbjct: 643 --------------------LKAEAEKADNSGPAATKRKVIYCTSLNWSADGSTLFSGYT 682 Query: 180 KGNCYVWEM 188 G VW + Sbjct: 683 DGVIRVWGI 691 Score = 87.8 bits (216), Expect = 5e-18, Method: Composition-based stats. Identities = 32/111 (28%), Positives = 51/111 (45%), Gaps = 5/111 (4%) Query: 196 HLKPVTKFRAHSTYITRILLSSDV-KHLATCSADHTARVWSIDDDFKL----ETTLDGHQ 250 L RAH+ +T I D + + S D + +W + D K + L GH Sbjct: 371 GLVLKGTMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHS 430 Query: 251 RWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 +V D S+D + ++ S D +RLWDL+ R++ GH K + VA + Sbjct: 431 HFVEDVVLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFS 481 >2H9P-A nrPDB Length = 329 Score = 207 bits (526), Expect = 6e-54, Method: Composition-based stats. Identities = 59/280 (21%), Positives = 121/280 (43%), Gaps = 16/280 (5%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQ-NVRLYDIRTT 63 L S+ D I+ W A G +TI ++ + ++D LL +A ++++D+ + Sbjct: 55 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG 114 Query: 64 NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEV 122 + + +GH V +F + +V+ S D ++++WDV++ + H+ PV+ V Sbjct: 115 K--CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAV 172 Query: 123 VIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGN 182 + + ++S DG RIWD QC L +D+ + + + +G + AA Sbjct: 173 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT 232 Query: 183 CYVWEMPNHTDASHLKPVTKFRAHSTYITRILLS---SDVKHLATCSADHTARVWSIDDD 239 +W+ K + + H I + + K + + S D+ +W++ Sbjct: 233 LKLWDYSKG------KCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK 286 Query: 240 FKLETTLDGHQRWVWDCAFSADSAYLVTAS--SDHYVRLW 277 ++ L GH V A + +A+ +D ++LW Sbjct: 287 -EIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 325 Score = 206 bits (523), Expect = 1e-53, Method: Composition-based stats. Identities = 61/282 (21%), Positives = 133/282 (47%), Gaps = 16/282 (5%) Query: 27 TIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQ 85 T+ V+ ++ + + + LA++ + ++++ + GH+ ++ V++ Sbjct: 35 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE--KTISGHKLGISDVAWSS 92 Query: 86 DNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDGNIRIWD 144 D+ +V++S+D T+K+WDV S + K H+ V +P ++S D ++RIWD Sbjct: 93 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 152 Query: 145 LGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFR 204 + +C L D + ++ DGS++ +++ G C +W+ + L Sbjct: 153 VKTGKCLKTLPAHSD-PVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL-----ID 206 Query: 205 AHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSA---- 260 + ++ + S + K++ + D+T ++W K T GH+ + C F+ Sbjct: 207 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG-KCLKTYTGHKNEKY-CIFANFSVT 264 Query: 261 DSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 ++V+ S D+ V +W+L T+EIV++ GH + A + Sbjct: 265 GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 306 Score = 178 bits (451), Expect = 3e-45, Method: Composition-based stats. Identities = 51/243 (20%), Positives = 105/243 (43%), Gaps = 15/243 (6%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDI 60 S +LVSA D T++ W+ +G C +T++ + V L+ + ++VR++D+ Sbjct: 94 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 153 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNA--P 118 +T + + H V++V F +D +V+SS DG ++WD S + + P Sbjct: 154 KTGK--CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 211 Query: 119 VNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSM--ASDGSMLAA 176 V+ V PN +++ D +++WD + +C T + + + G + + Sbjct: 212 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 271 Query: 177 ANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCS--ADHTARVW 234 + Y+W + + V K + H+ + +A+ + D T ++W Sbjct: 272 GSEDNLVYIWNL------QTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 325 Query: 235 SID 237 D Sbjct: 326 KSD 328 Score = 119 bits (299), Expect = 1e-27, Method: Composition-based stats. Identities = 38/157 (24%), Positives = 64/157 (40%), Gaps = 7/157 (4%) Query: 145 LGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFR 204 + N ++ S+ + +G LA+++ +W A K Sbjct: 26 VKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG------AYDGKFEKTIS 79 Query: 205 AHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAY 264 H I+ + SSD L + S D T ++W + K TL GH +V+ C F+ S Sbjct: 80 GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG-KCLKTLKGHSNYVFCCNFNPQSNL 138 Query: 265 LVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 +V+ S D VR+WD+ T + ++ H V N Sbjct: 139 IVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 175 Score = 108 bits (269), Expect = 4e-24, Method: Composition-based stats. Identities = 31/108 (28%), Positives = 55/108 (50%), Gaps = 1/108 (0%) Query: 195 SHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVW 254 + H+ ++ + S + + LA+ SAD ++W D K E T+ GH+ + Sbjct: 28 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG-KFEKTISGHKLGIS 86 Query: 255 DCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 D A+S+DS LV+AS D +++WD+S+ + ++ GH C N Sbjct: 87 DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP 134 >6HQA-B nrPDB Length = 722 Score = 202 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 59/287 (20%), Positives = 120/287 (41%), Gaps = 30/287 (10%) Query: 19 ALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQN-VRLYDIRTTNPNPV--------- 68 +L VC T ++++ + L+ +D ++A+ + ++L+ I + + Sbjct: 377 SLPSVCMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQ 436 Query: 69 ----------ASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNA 117 GH G V V F DNR++++ SED T+++W + + + +YK H++ Sbjct: 437 NNDGVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSS 496 Query: 118 PVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAA 177 V +V P + D R+W + + + + + L Sbjct: 497 SVWDVKFSPMGHYFATASHDQTARLWSCDHIYPLRIFAGHLN-DVDCVEFHPNSTYLFTG 555 Query: 178 NTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSID 237 ++ +W++ + V F HS I + +S D + LA+ D +W I Sbjct: 556 SSDKTARMWDIARG------ECVRVFMGHSGAINCLAVSPDGRWLASAGEDSVVCLWDIS 609 Query: 238 DDFKLETTLDGHQRW-VWDCAFSADSAYLVTASSDHYVRLWDLSTRE 283 +++ + GH R ++ AFS + LV+ +D+ VR+WD+ Sbjct: 610 TGRRIKA-MRGHGRSSIYSLAFSREGTVLVSTGADNSVRVWDVKKNT 655 Score = 187 bits (475), Expect = 5e-48, Method: Composition-based stats. Identities = 47/200 (23%), Positives = 92/200 (46%), Gaps = 4/200 (2%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDI 60 + L+S D T+R W T C + + S V ++ + ATA Q RL+ Sbjct: 465 NRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDVKFSPMGHYFATASHDQTARLWSC 524 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPV 119 + P+ F GH +V V F ++ ++ T S D T ++WD+ R + H+ + Sbjct: 525 D--HIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTARMWDIARGECVRVFMGHSGAI 582 Query: 120 NEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANT 179 N + + P+ L S D + +WD+ + + +S+ SL+ + +G++L + Sbjct: 583 NCLAVSPDGRWLASAGEDSVVCLWDISTGRRIKAMRGHGRSSIYSLAFSREGTVLVSTGA 642 Query: 180 KGNCYVWEMPNHTDASHLKP 199 + VW++ +T++ +P Sbjct: 643 DNSVRVWDVKKNTNSPSAQP 662 Score = 181 bits (459), Expect = 3e-46, Method: Composition-based stats. Identities = 56/263 (21%), Positives = 101/263 (38%), Gaps = 33/263 (12%) Query: 2 SVILVSAGYDHTIRFWEALTG---------------------VCSRTIQHSDSQVNRLEI 40 S ++ S D I+ W SR + V ++ Sbjct: 402 STMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGVAVKGSRRLVGHSGAVYGVDF 461 Query: 41 TNDKKLLATAG-HQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTI 99 + D + L + + VRL+ + T + S++GH +V V F + T+S D T Sbjct: 462 SPDNRYLISCSEDKTVRLWSLDTY--TCLVSYKGHSSSVWDVKFSPMGHYFATASHDQTA 519 Query: 100 KVWDVRSPSIPRNY-KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPED 158 ++W R + H V+ V HPN L + D R+WD+ +C Sbjct: 520 RLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTARMWDIARGECVRVFMGHS 579 Query: 159 DTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAH-STYITRILLSS 217 ++ L+++ DG LA+A +W++ S + + R H + I + S Sbjct: 580 G-AINCLAVSPDGRWLASAGEDSVVCLWDI------STGRRIKAMRGHGRSSIYSLAFSR 632 Query: 218 DVKHLATCSADHTARVWSIDDDF 240 + L + AD++ RVW + + Sbjct: 633 EGTVLVSTGADNSVRVWDVKKNT 655 Score = 174 bits (440), Expect = 5e-44, Method: Composition-based stats. Identities = 57/258 (22%), Positives = 96/258 (37%), Gaps = 31/258 (12%) Query: 67 PVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIP---------------- 110 + +F ++T + F D+ + + +D IK+W + + Sbjct: 382 CMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGV 441 Query: 111 ------RNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQS 164 R H+ V V P+ LISC D +R+W L C +S+ Sbjct: 442 AVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHS-SSVWD 500 Query: 165 LSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLAT 224 + + G A A+ +W H+ P+ F H + + + +L T Sbjct: 501 VKFSPMGHYFATASHDQTARLWSCD------HIYPLRIFAGHLNDVDCVEFHPNSTYLFT 554 Query: 225 CSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREI 284 S+D TAR+W I + GH + A S D +L +A D V LWD+ST Sbjct: 555 GSSDKTARMWDIARG-ECVRVFMGHSGAINCLAVSPDGRWLASAGEDSVVCLWDISTGRR 613 Query: 285 VRQYGGH-HKGAVCVALN 301 ++ GH +A + Sbjct: 614 IKAMRGHGRSSIYSLAFS 631 Score = 131 bits (329), Expect = 4e-31, Method: Composition-based stats. Identities = 36/167 (21%), Positives = 69/167 (41%), Gaps = 5/167 (2%) Query: 1 MSVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLAT-AGHQNVRLYD 59 M +A +D T R W R + V+ +E + L T + + R++D Sbjct: 506 MGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLFTGSSDKTARMWD 565 Query: 60 IRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KH-NA 117 I V F GH G + ++ D RW+ ++ ED + +WD+ + + H + Sbjct: 566 IARGE--CVRVFMGHSGAINCLAVSPDGRWLASAGEDSVVCLWDISTGRRIKAMRGHGRS 623 Query: 118 PVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQS 164 + + L+S D ++R+WD+ +N + PE + + Sbjct: 624 SIYSLAFSREGTVLVSTGADNSVRVWDVKKNTNSPSAQPEPINDVTA 670 Score = 123 bits (309), Expect = 8e-29, Method: Composition-based stats. Identities = 42/168 (25%), Positives = 64/168 (38%), Gaps = 17/168 (10%) Query: 150 CTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMP---------------NHTDA 194 C + + L L D +M+A+ +W + + D Sbjct: 382 CMYTFH-NTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDG 440 Query: 195 SHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVW 254 +K + HS + + S D ++L +CS D T R+WS+D + + GH VW Sbjct: 441 VAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDT-YTCLVSYKGHSSSVW 499 Query: 255 DCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 D FS Y TAS D RLW +R + GH CV + Sbjct: 500 DVKFSPMGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHP 547 Score = 89.7 bits (221), Expect = 1e-18, Method: Composition-based stats. Identities = 31/126 (24%), Positives = 48/126 (38%), Gaps = 22/126 (17%) Query: 199 PVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLD----------- 247 + F + +T + + D +A+ D ++WSID L + L Sbjct: 382 CMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSID-GSPLRSLLKNDPYNQQNNDG 440 Query: 248 ----------GHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVC 297 GH V+ FS D+ YL++ S D VRLW L T + Y GH Sbjct: 441 VAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWD 500 Query: 298 VALNDV 303 V + + Sbjct: 501 VKFSPM 506 >6G51-g nrPDB Length = 317 Score = 199 bits (506), Expect = 1e-51, Method: Composition-based stats. Identities = 66/298 (22%), Positives = 128/298 (42%), Gaps = 29/298 (9%) Query: 4 ILVSAGYDHTIRFWEAL-----TGVCSRTIQHSDSQVNRLEITNDKKL-LATAGHQNVRL 57 +++SA D TI W+ G+ R ++ V+ + I++D + L+ + +RL Sbjct: 30 MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRL 89 Query: 58 YDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS--IPRNYKH 115 +D+ T F GH +V SV+F DNR +V+ S D TIK+W+ ++ H Sbjct: 90 WDLTTG--TTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESH 147 Query: 116 NAPVNEVVIHPN--QGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSM 173 + V+ V PN ++SC D +++W+L + L +++++ DGS+ Sbjct: 148 SEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGY-LNTVTVSPDGSL 206 Query: 174 LAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARV 233 A+ G +W++ L I + S + ++ + + ++ Sbjct: 207 CASGGKDGQAMLWDLNEGKHLYTLD-------GGDIINALCFSPN-RYWLCAATGPSIKI 258 Query: 234 WSID-----DDFKLETTLDGHQRW---VWDCAFSADSAYLVTASSDHYVRLWDLSTRE 283 W ++ D+ K E + A+SAD L +D+ VR+W ++ Sbjct: 259 WDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 Score = 152 bits (383), Expect = 2e-37, Method: Composition-based stats. Identities = 56/272 (20%), Positives = 119/272 (43%), Gaps = 19/272 (6%) Query: 27 TIQHSDSQVNRLEITNDKK--LLATAGHQNVRLYDI---RTTNPNPVASFEGHRGNVTSV 81 T++ + V ++ T +L+ + + + ++ + T P + GH V+ V Sbjct: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 Query: 82 SFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQGELISCDRDGNI 140 D ++ ++ S DGT+++WD+ + + R + H V V + +++S RD I Sbjct: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129 Query: 141 RIWDLGENQCTHQLTPEDDTS-LQSLSMASDGS--MLAAANTKGNCYVWEMPNHTDASHL 197 ++W+ C + + E + + + + + S ++ + VW + N Sbjct: 130 KLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN------C 182 Query: 198 KPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCA 257 K T H+ Y+ + +S D A+ D A +W +++ K TLDG + Sbjct: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEG-KHLYTLDG-GDIINALC 240 Query: 258 FSADSAYLVTASSDHYVRLWDLSTREIVRQYG 289 FS + Y + A++ +++WDL + IV + Sbjct: 241 FSPN-RYWLCAATGPSIKIWDLEGKIIVDELK 271 Score = 142 bits (357), Expect = 2e-34, Method: Composition-based stats. Identities = 52/250 (20%), Positives = 101/250 (40%), Gaps = 17/250 (6%) Query: 62 TTNPNPVASFEGHRGNVTSVSFQQD-NRWMVTSSEDGTIKVWDVRSPSIPRNY------K 114 T + +GH G VT ++ ++++S D TI +W + Sbjct: 2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG 61 Query: 115 HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSML 174 H+ V++VVI + +S DG +R+WDL T + + S++ +SD + Sbjct: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTK-DVLSVAFSSDNRQI 120 Query: 175 AAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVK--HLATCSADHTAR 232 + + +W K + +HS +++ + S + + +C D + Sbjct: 121 VSGSRDKTIKLWNTLGV-----CKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175 Query: 233 VWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHH 292 VW++ + KL+T GH ++ S D + + D LWDL+ + + G Sbjct: 176 VWNLAN-CKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD 234 Query: 293 -KGAVCVALN 301 A+C + N Sbjct: 235 IINALCFSPN 244 Score = 120 bits (301), Expect = 7e-28, Method: Composition-based stats. Identities = 40/196 (20%), Positives = 81/196 (41%), Gaps = 13/196 (6%) Query: 114 KHNAPVNEVVIHPNQG-ELISCDRDGNIRIWDLGENQCTHQL----TPEDDTSLQSLSMA 168 HN V ++ P ++S RD I +W L ++ + + + + ++ Sbjct: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS 72 Query: 169 SDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSAD 228 SDG + + G +W++ T +F H+ + + SSD + + + S D Sbjct: 73 SDGQFALSGSWDGTLRLWDLTTGT------TTRRFVGHTKDVLSVAFSSDNRQIVSGSRD 126 Query: 229 HTARVWSIDDDFKLETTLDGHQRWVWDCAFSADS--AYLVTASSDHYVRLWDLSTREIVR 286 T ++W+ K + H WV FS +S +V+ D V++W+L+ ++ Sbjct: 127 KTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT 186 Query: 287 QYGGHHKGAVCVALND 302 + GH V ++ Sbjct: 187 NHIGHTGYLNTVTVSP 202 Score = 99.0 bits (245), Expect = 2e-21, Method: Composition-based stats. Identities = 34/158 (21%), Positives = 67/158 (42%), Gaps = 3/158 (1%) Query: 146 GENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRA 205 + L + Q + M+ +A+ +W++ + ++ P R Sbjct: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLT-RDETNYGIPQRALRG 61 Query: 206 HSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYL 265 HS +++ +++SSD + + S D T R+W + GH + V AFS+D+ + Sbjct: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRR-FVGHTKDVLSVAFSSDNRQI 120 Query: 266 VTASSDHYVRLWD-LSTREIVRQYGGHHKGAVCVALND 302 V+ S D ++LW+ L + Q H + CV + Sbjct: 121 VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSP 158 Score = 81.7 bits (200), Expect = 3e-16, Method: Composition-based stats. Identities = 35/192 (18%), Positives = 67/192 (34%), Gaps = 38/192 (19%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDI 60 + I+VS G+D ++ W +N + ++ D L A+ G L+D+ Sbjct: 162 NPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL 221 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVN 120 + + +G + ++ F + W+ + +IK+WD+ I K Sbjct: 222 NEGKH--LYTLDG-GDIINALCFSPNRYWLCAA-TGPSIKIWDLEGKIIVDELK------ 271 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 E+IS + + SL+ ++DG L A T Sbjct: 272 --------QEVISTS-------------------SKAEPPQCTSLAWSADGQTLFAGYTD 304 Query: 181 GNCYVWEMPNHT 192 VW++ T Sbjct: 305 NLVRVWQVTIGT 316 >6MZM-G nrPDB Length = 800 Score = 199 bits (506), Expect = 1e-51, Method: Composition-based stats. Identities = 64/292 (21%), Positives = 105/292 (35%), Gaps = 39/292 (13%) Query: 18 EALTGVCSRTIQHSDSQVNRLEITNDKKLLATA-GHQNVRLYDIRTTNPNPV-------- 68 + L +C T ++ + +++T+D L+A VR+ Sbjct: 456 DCLPSICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVXXXXXXXXXXXXXXXXXXX 515 Query: 69 ---------------------ASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSP 107 GH G V SF D ++++SSEDGT+++W +++ Sbjct: 516 XXXXXXXXXXXXXXXXXXXXXKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTF 575 Query: 108 SIPRNYK-HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLS 166 + YK HN PV + P +S D R+W Q + Sbjct: 576 TCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHL-ADVNCTR 634 Query: 167 MASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCS 226 + + +A + +W++ N V F H I + S + + LAT + Sbjct: 635 FHPNSNYVATGSADRTVRLWDVLNGN------CVRIFTGHKGPIHSLTFSPNGRFLATGA 688 Query: 227 ADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWD 278 D +W I + L GH V FS D L + S D+ VRLWD Sbjct: 689 TDGRVLLWDIGHGL-MVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 55/245 (22%), Positives = 97/245 (39%), Gaps = 23/245 (9%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNV-RLYDIR 61 L+S+ D T+R W T C + + V + + + GH V RL+ Sbjct: 556 NYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLW--A 613 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVN 120 T + P+ F GH +V F ++ ++ T S D T+++WDV + + R + H P++ Sbjct: 614 TDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIH 673 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 + PN L + DG + +WD+G +L DT + SL + DG +LA+ + Sbjct: 674 SLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDT-VCSLRFSRDGEILASGSMD 732 Query: 181 GNCYVWEMPNHTDASHLKPVTKFRAH------------------STYITRILLSSDVKHL 222 +W+ + T H ST + + + L Sbjct: 733 NTVRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVVHLHFTRRNLVL 792 Query: 223 ATCSA 227 A + Sbjct: 793 AAGAY 797 Score = 186 bits (473), Expect = 8e-48, Method: Composition-based stats. Identities = 53/229 (23%), Positives = 91/229 (39%), Gaps = 16/229 (6%) Query: 28 IQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQD 86 + V + D+ L ++ VRL+ ++T + ++GH V F Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTF--TCLVGYKGHNYPVWDTQFSPY 596 Query: 87 NRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQGELISCDRDGNIRIWDL 145 + V+ D ++W R + H A VN HPN + + D +R+WD+ Sbjct: 597 GYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDV 656 Query: 146 GENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRA 205 C T + SL+ + +G LA T G +W++ H V + + Sbjct: 657 LNGNCVRIFTGHKG-PIHSLTFSPNGRFLATGATDGRVLLWDI------GHGLMVGELKG 709 Query: 206 HSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLE-----TTLDGH 249 H+ + + S D + LA+ S D+T R+W F+ TT GH Sbjct: 710 HTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGH 758 Score = 166 bits (421), Expect = 8e-42, Method: Composition-based stats. Identities = 41/189 (21%), Positives = 72/189 (38%), Gaps = 8/189 (4%) Query: 113 YKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGS 172 Y H+ PV P++ L+S DG +R+W L C + + + G Sbjct: 540 YGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGH-NYPVWDTQFSPYGY 598 Query: 173 MLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTAR 232 + +W H +P+ F H + + ++AT SAD T R Sbjct: 599 YFVSGGHDRVARLWATD------HYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVR 652 Query: 233 VWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHH 292 +W + + GH+ + FS + +L T ++D V LWD+ +V + GH Sbjct: 653 LWDVLNG-NCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHT 711 Query: 293 KGAVCVALN 301 + + Sbjct: 712 DTVCSLRFS 720 Score = 127 bits (319), Expect = 6e-30, Method: Composition-based stats. Identities = 30/150 (20%), Positives = 57/150 (38%), Gaps = 7/150 (4%) Query: 153 QLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITR 212 ++ + S + D + L +++ G +W + + ++ H+ + Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL------QTFTCLVGYKGHNYPVWD 590 Query: 213 ILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDH 272 S + + D AR+W D ++ GH V F +S Y+ T S+D Sbjct: 591 TQFSPYGYYFVSGGHDRVARLW-ATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADR 649 Query: 273 YVRLWDLSTREIVRQYGGHHKGAVCVALND 302 VRLWD+ VR + GH + + Sbjct: 650 TVRLWDVLNGNCVRIFTGHKGPIHSLTFSP 679 Score = 113 bits (283), Expect = 8e-26, Method: Composition-based stats. Identities = 30/103 (29%), Positives = 49/103 (47%), Gaps = 3/103 (2%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLAT-AGHQNVRLYDI 60 S + + D T+R W+ L G C R ++ L + + + LAT A V L+DI Sbjct: 639 SNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDI 698 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWD 103 + V +GH V S+ F +D + + S D T+++WD Sbjct: 699 --GHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739 >4V6W-Ag nrPDB Length = 318 Score = 199 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 61/295 (20%), Positives = 125/295 (42%), Gaps = 30/295 (10%) Query: 5 LVSAGYDHTIRFW------EALTGVCSRTIQHSDSQVNRLEITNDKKL-LATAGHQNVRL 57 ++SA D T+ W + G + + ++ + +++D L+ + Q +RL Sbjct: 31 IISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDVVLSSDGNYALSGSWDQTLRL 90 Query: 58 YDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS--IPRNYKH 115 +D+ FEGH +V SV+F DNR +V+ S D TIK+W+ + + H Sbjct: 91 WDLAAGKT--TRRFEGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTLAECKFTIQEDGH 148 Query: 116 NAPVNEVVIHPNQ--GELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSM 173 V+ V PN ++SC D +++W+L + + + L +++++ DGS+ Sbjct: 149 TDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCKLKNNHHGHNGY-LNTVTVSPDGSL 207 Query: 174 LAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARV 233 + +W++ + + L+ H+ I + S + ++ + + ++ Sbjct: 208 CTSGGKDSKALLWDLNDGKNLYTLE-------HNDIINALCFSPN-RYWLCVAYGPSIKI 259 Query: 234 WSID--------DDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLS 280 W + + T Q A+S D L SD+ +R+W +S Sbjct: 260 WDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTLFAGYSDNTIRVWQVS 314 Score = 151 bits (382), Expect = 3e-37, Method: Composition-based stats. Identities = 55/280 (19%), Positives = 110/280 (39%), Gaps = 18/280 (6%) Query: 19 ALTGVCSRTIQHSDSQVNRLEITNDKK--LLATAGHQNVRLY----DIRTTNPNPVASFE 72 + T T+ + V ++ +++ + + + ++ D T P Sbjct: 2 SETLQLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLY 61 Query: 73 GHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQGEL 131 GH ++ V D + ++ S D T+++WD+ + R + H V V + ++ Sbjct: 62 GHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQI 121 Query: 132 ISCDRDGNIRIWD-LGENQCTHQLTPEDD-TSLQSLSMASDGSMLAAANTKGNCYVWEMP 189 +S RD I++W+ L E + T Q D S S ++ + VW + Sbjct: 122 VSGSRDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLA 181 Query: 190 NHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGH 249 N K H+ Y+ + +S D + D A +W ++D K TL+ H Sbjct: 182 N------CKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDG-KNLYTLE-H 233 Query: 250 QRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYG 289 + FS + +L A +++WDL+ ++ V + Sbjct: 234 NDIINALCFSPNRYWLCVAYG-PSIKIWDLACKKTVEELR 272 Score = 144 bits (363), Expect = 4e-35, Method: Composition-based stats. Identities = 46/251 (18%), Positives = 101/251 (40%), Gaps = 18/251 (7%) Query: 62 TTNPNPVASFEGHRGNVTSVSFQQ-DNRWMVTSSEDGTIKVWDVRSPS-------IPRNY 113 + + GH G VT ++ D ++++S D T+ VW + R Y Sbjct: 2 SETLQLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLY 61 Query: 114 KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSM 173 H+ +++VV+ + +S D +R+WDL + T + + S++ ++D Sbjct: 62 GHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTK-DVLSVAFSADNRQ 120 Query: 174 LAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSD--VKHLATCSADHTA 231 + + + +W + K + H+ +++ + S + + +C D T Sbjct: 121 IVSGSRDKTIKLWNTL-----AECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTV 175 Query: 232 RVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGH 291 +VW++ + KL+ GH ++ S D + + D LWDL+ + + H Sbjct: 176 KVWNLAN-CKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLE-H 233 Query: 292 HKGAVCVALND 302 + + + Sbjct: 234 NDIINALCFSP 244 Score = 81.3 bits (199), Expect = 5e-16, Method: Composition-based stats. Identities = 27/156 (17%), Positives = 59/156 (37%), Gaps = 15/156 (9%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDI 60 + I+VS G+D T++ W + +N + ++ D L + G L+D+ Sbjct: 163 NPIIVSCGWDRTVKVWNLANCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDL 222 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK--HNAP 118 + + E H + ++ F + W+ + +IK+WD+ + +P Sbjct: 223 NDGK--NLYTLE-HNDIINALCFSPNRYWLCVA-YGPSIKIWDLACKKTVEELRPEVVSP 278 Query: 119 VN--------EVVIHPNQGELISCDRDGNIRIWDLG 146 + + + L + D IR+W + Sbjct: 279 TSKADQPQCLSLAWSTDGQTLFAGYSDNTIRVWQVS 314 >6HHQ-h nrPDB Length = 319 Score = 194 bits (492), Expect = 5e-50, Method: Composition-based stats. Identities = 68/300 (22%), Positives = 128/300 (42%), Gaps = 30/300 (10%) Query: 3 VILVSAGYDHTIRFW-----EALTGVCSRTIQHSDSQVNRLEITNDKKL-LATAGHQNVR 56 +L+SA D T+ W + GV R+ + V +T D L+ + + +R Sbjct: 31 NLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDCTLTADGAYALSASWDKTLR 90 Query: 57 LYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHN 116 L+D+ T F GH+ +V SV + +++ S D TIKVW ++ + HN Sbjct: 91 LWDVATGET--YQRFVGHKSDVMSVDIDKKASMIISGSRDKTIKVWTIKGQCLATLLGHN 148 Query: 117 APVNEVVIHPNQG------ELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASD 170 V++V + PN+ +IS D ++ W+L + Q ++++ +L+ + D Sbjct: 149 DWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQIEADFIGH-NSNINTLTASPD 207 Query: 171 GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHT 230 G+++A+A G +W + L + + S + LA +A Sbjct: 208 GTLIASAGKDGEIMLWNLAAKKAMYTLSA-------QDEVFSLAFSPNRYWLAAATATG- 259 Query: 231 ARVWSIDDDF---KLETTLDGHQRW----VWDCAFSADSAYLVTASSDHYVRLWDLSTRE 283 +V+S+D + L G+ + A+SAD L +D+ +R+W + T Sbjct: 260 IKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQVMTAN 319 Score = 132 bits (331), Expect = 3e-31, Method: Composition-based stats. Identities = 41/246 (16%), Positives = 99/246 (40%), Gaps = 23/246 (9%) Query: 70 SFEGHRGNVTSVSFQQDN-RWMVTSSEDGTIKVWDVRS-----PSIPRNYK-HNAPVNEV 122 + EGH G VTS++ ++++S D T+ W + R++K H+ V + Sbjct: 12 TLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDC 71 Query: 123 VIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGN 182 + + +S D +R+WD+ + + + + S+ + SM+ + + Sbjct: 72 TLTADGAYALSASWDKTLRLWDVATGETYQRFVGHK-SDVMSVDIDKKASMIISGSRDKT 130 Query: 183 CYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVK------HLATCSADHTARVWSI 236 VW + + + H+ +++++ + + K + + D + W++ Sbjct: 131 IKVWTIK-------GQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWNL 183 Query: 237 DDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAV 296 + F++E GH + S D + +A D + LW+L+ ++ + Sbjct: 184 -NQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLSA-QDEVF 241 Query: 297 CVALND 302 +A + Sbjct: 242 SLAFSP 247 Score = 117 bits (293), Expect = 6e-27, Method: Composition-based stats. Identities = 40/199 (20%), Positives = 84/199 (42%), Gaps = 18/199 (9%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKK-------LLATAGHQN 54 + +++S D TI+ W + G C T+ + V+++ + ++K +++ + Sbjct: 119 ASMIISGSRDKTIKVW-TIKGQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKM 177 Query: 55 VRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK 114 V+ +++ A F GH N+ +++ D + ++ +DG I +W++ + Sbjct: 178 VKAWNL--NQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYTLS 235 Query: 115 HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPE-------DDTSLQSLSM 167 V + PN+ L + G I+++ L L PE + SL+ Sbjct: 236 AQDEVFSLAFSPNRYWLAAATATG-IKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAW 294 Query: 168 ASDGSMLAAANTKGNCYVW 186 ++DG L A T VW Sbjct: 295 SADGQTLFAGYTDNVIRVW 313 Score = 70.5 bits (171), Expect = 9e-13, Method: Composition-based stats. Identities = 29/156 (18%), Positives = 62/156 (39%), Gaps = 14/156 (8%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDI 60 SV ++SAG D ++ W +S +N L + D L+A+AG + L+++ Sbjct: 166 SVTIISAGNDKMVKAWNLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNL 225 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-----KH 115 + + + V S++F + W+ ++ G IKV+ + + + + Sbjct: 226 AA--KKAMYTLSA-QDEVFSLAFSPNRYWLAAATATG-IKVFSLDPQYLVDDLRPEFAGY 281 Query: 116 NAPVN----EVVIHPNQGELISCDRDGNIRIWDLGE 147 + + + L + D IR+W + Sbjct: 282 SKAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQVMT 317 Score = 50.5 bits (119), Expect = 9e-07, Method: Composition-based stats. Identities = 24/109 (22%), Positives = 37/109 (33%), Gaps = 48/109 (44%) Query: 242 LETTLDGHQRWVWDCA-------------------------------------------- 257 L TL+GH WV A Sbjct: 9 LRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIV 68 Query: 258 ----FSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 +AD AY ++AS D +RLWD++T E +++ GH + V ++ Sbjct: 69 QDCTLTADGAYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDIDK 117 >3JAP-g nrPDB Length = 326 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 61/305 (20%), Positives = 122/305 (40%), Gaps = 34/305 (11%) Query: 3 VILVSAGYDHTIRFWEA-----LTGVCSRTIQHSDSQVNRLEITNDKKL-LATAGHQNVR 56 +LVS D T+ W GV R+ + V + ++ D ++ + + +R Sbjct: 32 NLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDVVVSADGNYAVSASWDKTLR 91 Query: 57 LYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHN 116 L+++ T N A F GH G+V SV+ ++ ++++S D TI+VW+ H Sbjct: 92 LWNLATGNSE--ARFVGHTGDVLSVAIDANSSKIISASRDKTIRVWNTVGDCAYVLLGHT 149 Query: 117 APVNEVVIHPNQG----------ELISCDRDGNIRIWDLGENQ-CTHQLTPEDDTSLQSL 165 V +V + P +S D +R W L E+ + + + Sbjct: 150 DWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWSLNEDSYRIEADFIGHNNYINVV 209 Query: 166 SMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATC 225 + DGS+ A+A G YVW + + + + + + S + T Sbjct: 210 QPSPDGSLAASAGKDGQIYVWNLKHKSAFMNFDA-------KDEVFALAFSPS-RFWLTA 261 Query: 226 SADHTARVWSIDDDF---KLETTLDGHQRW----VWDCAFSADSAYLVTASSDHYVRLWD 278 + +++ ++++ +L+ G+ + A+SAD L +D+ +R+W Sbjct: 262 ATASGIKIYDLENEVLIDELKPEFAGYTKAQDPHAVSLAWSADGQTLFAGYTDNVIRVWQ 321 Query: 279 LSTRE 283 + T Sbjct: 322 VMTAN 326 Score = 130 bits (327), Expect = 6e-31, Method: Composition-based stats. Identities = 48/251 (19%), Positives = 99/251 (39%), Gaps = 27/251 (10%) Query: 70 SFEGHRGNVTSVSFQQDN-RWMVTSSEDGTIKVWDVRS-----PSIPRNYK-HNAPVNEV 122 + EGH G VTS+S +V+ S D T+ W + R+YK H+ V +V Sbjct: 13 TLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDV 72 Query: 123 VIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGN 182 V+ + +S D +R+W+L + + S+++ ++ S + +A+ Sbjct: 73 VVSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTG-DVLSVAIDANSSKIISASRDKT 131 Query: 183 CYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSS---------DVKH-LATCSADHTAR 232 VW H+ ++T++ ++ D + + D R Sbjct: 132 IRVWNTV-------GDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVR 184 Query: 233 VWSIDDD-FKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGH 291 WS+++D +++E GH ++ S D + +A D + +W+L + + Sbjct: 185 SWSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMNFDA- 243 Query: 292 HKGAVCVALND 302 +A + Sbjct: 244 KDEVFALAFSP 254 Score = 110 bits (274), Expect = 9e-25, Method: Composition-based stats. Identities = 47/203 (23%), Positives = 79/203 (38%), Gaps = 20/203 (9%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDK-----------KLLATA 50 S ++SA D TIR W + G C+ + V ++ + ++ Sbjct: 120 SSKIISASRDKTIRVWNTV-GDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAG 178 Query: 51 GHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIP 110 + VR + + + A F GH + V D ++ +DG I VW+++ S Sbjct: 179 MDKIVRSWSLNEDSYRIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAF 238 Query: 111 RNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPE-------DDTSLQ 163 N+ V + P++ L + G I+I+DL +L PE D Sbjct: 239 MNFDAKDEVFALAFSPSRFWLTAATASG-IKIYDLENEVLIDELKPEFAGYTKAQDPHAV 297 Query: 164 SLSMASDGSMLAAANTKGNCYVW 186 SL+ ++DG L A T VW Sbjct: 298 SLAWSADGQTLFAGYTDNVIRVW 320 Score = 47.8 bits (112), Expect = 5e-06, Method: Composition-based stats. Identities = 24/108 (22%), Positives = 35/108 (32%), Gaps = 48/108 (44%) Query: 242 LETTLDGHQRWVWDCA-------------------------------------------- 257 L TL+GH WV + Sbjct: 10 LRGTLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIV 69 Query: 258 ----FSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 SAD Y V+AS D +RLW+L+T ++ GH + VA++ Sbjct: 70 QDVVVSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAID 117 >5OQL-d nrPDB Length = 446 Score = 187 bits (476), Expect = 4e-48, Method: Composition-based stats. Identities = 67/287 (23%), Positives = 124/287 (43%), Gaps = 17/287 (5%) Query: 5 LVSAGYDHTIRFWEALTGVCSR-TIQHSDSQVNRLEITNDKKLLATAGHQNVRLYD--IR 61 + S D ++ W+ T + ++ V L TNDKKLL+ A ++L+D Sbjct: 82 IASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTFTNDKKLLSCATDG-IKLWDPYAS 140 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPV-- 119 +N P+A+++ G TS+SF + SS G I++WD+ + + + + V Sbjct: 141 PSNTTPIATWQ-EGGPYTSLSFHRSANTFAASSGQGCIRIWDLEHSTAGQAIQWPSFVDT 199 Query: 120 -NEVVIHPNQGELI-SCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMAS-DGSMLAA 176 +V + + +I S D +I ++DL N + + + + LA Sbjct: 200 ITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLH--FACNRIVFNPMEAMNLAV 257 Query: 177 ANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI 236 A+ N Y+++ N A +++ + H + + S + L + S D T R+W Sbjct: 258 ASEDHNIYIFDARNFDKALNIQ-----KGHVAAVMDVEFSPTGEELVSGSYDRTIRLWRR 312 Query: 237 DDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTRE 283 D + + V+ ++ DS Y++T S D VRLW + E Sbjct: 313 DAGHSRDVYHTKRMQRVFRTMWTMDSKYILTGSDDGNVRLWRANASE 359 Score = 113 bits (283), Expect = 8e-26, Method: Composition-based stats. Identities = 64/269 (23%), Positives = 99/269 (36%), Gaps = 56/269 (20%) Query: 73 GHRGNVTSVSFQQDN-RWMVTSSEDGTIKVWDV--RSPSIPRNYKHNAPVNEVVIHPNQG 129 GH V S+ +++ + + S DG +KVWD+ R R HN V + N Sbjct: 64 GHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTFT-NDK 122 Query: 130 ELISCDRDGNIRIWD--LGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWE 187 +L+SC DG I++WD + T T ++ SLS + AA++ +G +W+ Sbjct: 123 KLLSCATDG-IKLWDPYASPSNTTPIATWQEGGPYTSLSFHRSANTFAASSGQGCIRIWD 181 Query: 188 MPNHT---------------------------------------DASHLKPVTKFRAHST 208 + + T D PV K H Sbjct: 182 LEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLH-F 240 Query: 209 YITRILLSS-DVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVT 267 RI+ + + +LA S DH ++ + K GH V D FS LV+ Sbjct: 241 ACNRIVFNPMEAMNLAVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPTGEELVS 300 Query: 268 ASSDHYVRLWDLSTREIVRQYGGHHKGAV 296 S D +RLW R+ GH + Sbjct: 301 GSYDRTIRLW--------RRDAGHSRDVY 321 Score = 47.4 bits (111), Expect = 7e-06, Method: Composition-based stats. Identities = 24/68 (35%), Positives = 31/68 (45%), Gaps = 4/68 (5%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSD--SQVNRLEITNDKKLLATAGHQ-NVRLYDIR 61 LVS YD TIR W G SR + H+ +V R T D K + T NVRL+ Sbjct: 298 LVSGSYDRTIRLWRRDAGH-SRDVYHTKRMQRVFRTMWTMDSKYILTGSDDGNVRLWRAN 356 Query: 62 TTNPNPVA 69 + + V Sbjct: 357 ASERSGVK 364 Score = 40.4 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 13/58 (22%), Positives = 27/58 (46%), Gaps = 2/58 (3%) Query: 247 DGHQRWVWDCAFSADS-AYLVTASSDHYVRLWDLSTREIVR-QYGGHHKGAVCVALND 302 +GH + V+ +S + + S D V++WDL+TR+ + H+ + + Sbjct: 63 NGHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTFTN 120 Score = 27.3 bits (59), Expect = 7.7, Method: Composition-based stats. Identities = 5/18 (27%), Positives = 9/18 (50%) Query: 2 SVILVSAGYDHTIRFWEA 19 S +++ D +R W A Sbjct: 338 SKYILTGSDDGNVRLWRA 355 >3JB9-L nrPDB Length = 340 Score = 187 bits (474), Expect = 7e-48, Method: Composition-based stats. Identities = 64/281 (22%), Positives = 116/281 (41%), Gaps = 8/281 (2%) Query: 4 ILVSAGYDHTIRFWEALTGVCSR-TIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRT 62 S G D I W V + + + L+ + D +++ + L Sbjct: 64 YFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQWSRDSRVVYCSSSDTH-LMSWDA 122 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTS-SEDGTIKVWDVRSPSIPRNYKHNAPVNE 121 + + +GH G V ++ + ++TS S+D T+KVWD RS + + P+ Sbjct: 123 VSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRSKDCIKTIEEKYPLTA 182 Query: 122 VVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKG 181 V I ++ DG I+IWDL N C+H L D + SL+++ DGS L + + Sbjct: 183 VAIAQQGTQVFIGGIDGAIKIWDLRNNHCSHVLKGHKDI-ITSLAISKDGSSLLSNSMDN 241 Query: 182 NCYVWEMPNHTDASHLKPVTKFRAHSTY--ITRILLSSDVKHLATCSADHTARVWSIDDD 239 ++++ A + + H + + S + + + S+D VWS D Sbjct: 242 TVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVWSATGD 301 Query: 240 FKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLS 280 + L GH+ V F +++ SSD + L +L+ Sbjct: 302 LR--YVLPGHEGSVNHVDFHPHQDIILSCSSDRTIFLGELN 340 Score = 127 bits (319), Expect = 7e-30, Method: Composition-based stats. Identities = 45/240 (18%), Positives = 97/240 (40%), Gaps = 20/240 (8%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITN-DKKLLATAGHQ-NVRLYD 59 S ++ + D + W+A++G R + VN L++ +LL + ++++D Sbjct: 105 SRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWD 164 Query: 60 IRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAP 118 R+ + + + E + +T+V+ Q + DG IK+WD+R+ K H Sbjct: 165 SRS--KDCIKTIE-EKYPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCSHVLKGHKDI 221 Query: 119 VNEVVIHPNQGELISCDRDGNIRIWDL-------GENQCTHQLTPEDDTSLQSLSMASDG 171 + + I + L+S D +RI+D+ + Q + +L ++ + + Sbjct: 222 ITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNS 281 Query: 172 SMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTA 231 + A ++ N YVW ++ H + + + +CS+D T Sbjct: 282 RFVGAGSSDKNVYVW-------SATGDLRYVLPGHEGSVNHVDFHPHQDIILSCSSDRTI 334 Score = 124 bits (311), Expect = 4e-29, Method: Composition-based stats. Identities = 50/282 (17%), Positives = 94/282 (33%), Gaps = 61/282 (21%) Query: 73 GHRGNVTSVSFQQDNRWMVTSSEDGTIKVWD----------------------------- 103 GH V F + + D I +W+ Sbjct: 48 GHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQWSRDSRV 107 Query: 104 ---------------VRSPSIPRNYKHNAPVNEVVIHPNQGELI-SCDRDGNIRIWDLGE 147 V I ++ H VN + + EL+ S D +++WD Sbjct: 108 VYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRS 167 Query: 148 NQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHS 207 C + E+ L ++++A G+ + G +W++ N+ + H Sbjct: 168 KDCIKTI--EEKYPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNH------CSHVLKGHK 219 Query: 208 TYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLD-------GHQRWVWDCAFSA 260 IT + +S D L + S D+T R++ + + L G + + A+S Sbjct: 220 DIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSR 279 Query: 261 DSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 +S ++ SSD V +W +T ++ GH V + Sbjct: 280 NSRFVGAGSSDKNVYVWS-ATGDLRYVLPGHEGSVNHVDFHP 320 Score = 101 bits (251), Expect = 4e-22, Method: Composition-based stats. Identities = 34/194 (17%), Positives = 82/194 (42%), Gaps = 15/194 (7%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDI 60 S +L S D T++ W++ + C +TI+ + + I + G ++++D+ Sbjct: 148 SELLTSVSDDCTMKVWDSRSKDCIKTIEE-KYPLTAVAIAQQGTQVFIGGIDGAIKIWDL 206 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDV-------RSPSIPRNY 113 R + + V +GH+ +TS++ +D ++++S D T++++DV R I Sbjct: 207 RNNHCSHV--LKGHKDIITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGA 264 Query: 114 KH--NAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDG 171 H + V N + + D N+ +W + P + S+ + Sbjct: 265 IHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVWSAT--GDLRYVLPGHEGSVNHVDFHPHQ 322 Query: 172 SMLAAANTKGNCYV 185 ++ + ++ ++ Sbjct: 323 DIILSCSSDRTIFL 336 Score = 100 bits (250), Expect = 6e-22, Method: Composition-based stats. Identities = 30/194 (15%), Positives = 70/194 (36%), Gaps = 9/194 (4%) Query: 110 PRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMAS 169 + + H A V P+ S D I +W++ + + + ++ L + Sbjct: 44 LQMFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQWSR 103 Query: 170 DGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATC-SAD 228 D ++ +++ + W+ A + + K + H+ + + + L T S D Sbjct: 104 DSRVVYCSSSDTHLMSWD------AVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDD 157 Query: 229 HTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQY 288 T +VW ++T + + + A + + D +++WDL Sbjct: 158 CTMKVWDSRSKDCIKTIEEKY--PLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCSHVL 215 Query: 289 GGHHKGAVCVALND 302 GH +A++ Sbjct: 216 KGHKDIITSLAISK 229 Score = 72.0 bits (175), Expect = 3e-13, Method: Composition-based stats. Identities = 22/105 (20%), Positives = 45/105 (42%) Query: 199 PVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAF 258 P + H+ + + A+ D +W++ D K L+G + + D + Sbjct: 42 PNLQMFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQW 101 Query: 259 SADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALNDV 303 S DS + +SSD ++ WD + + +R++ GH + + V Sbjct: 102 SRDSRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKV 146 >5NZU-C nrPDB Length = 905 Score = 186 bits (472), Expect = 1e-47, Method: Composition-based stats. Identities = 45/238 (18%), Positives = 97/238 (40%), Gaps = 11/238 (4%) Query: 69 ASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNA-PVNEVVIHPN 127 V SV WM+ S +G++ VW+ + ++ + ++ PV Sbjct: 9 RKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVAR 68 Query: 128 QGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWE 187 + +++ D IR+++ + H D ++ +++ + ++ +W+ Sbjct: 69 KNWVVTGADDMQIRVFNYNTLERVHMFEAHSDY-IRCIAVHPTQPFILTSSDDMLIKLWD 127 Query: 188 MPNHTDASHLKPVTKFRAHSTYITRILLSS-DVKHLATCSADHTARVWSIDDDFKLETTL 246 S F H+ Y+ +I+++ D A+ S D T +VW + TL Sbjct: 128 WDKKWSCSQ-----VFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNF-TL 181 Query: 247 DGHQRWVWDCAF--SADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 +GH++ V + D YL++ + D V++WD + V+ GH + C + + Sbjct: 182 EGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHP 239 Score = 170 bits (430), Expect = 9e-43, Method: Composition-based stats. Identities = 56/279 (20%), Positives = 117/279 (41%), Gaps = 14/279 (5%) Query: 26 RTIQHSDSQVNRLEITNDKKL-LATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQ 84 R + +V +++ + LA+ + +V +++ T V +FE V + F Sbjct: 9 RKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHET--QTLVKTFEVCDLPVRAAKFV 66 Query: 85 QDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDGNIRIW 143 W+VT ++D I+V++ + ++ H+ + + +HP Q +++ D I++W Sbjct: 67 ARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLW 126 Query: 144 DL-GENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTK 202 D + C+ +Q + D + A+A+ VW++ + + P Sbjct: 127 DWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSS------PNFT 180 Query: 203 FRAHSTYITRILLSSDVK--HLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSA 260 H + I S +L + + D ++W + ++ TL+GH + V +F Sbjct: 181 LEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQ-TLEGHAQNVSCASFHP 239 Query: 261 DSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVA 299 + ++T S D VR+W ST + + CVA Sbjct: 240 ELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVA 278 Score = 137 bits (345), Expect = 5e-33, Method: Composition-based stats. Identities = 41/232 (17%), Positives = 80/232 (34%), Gaps = 13/232 (5%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQN-VRLYDIRTT 63 +V+ D IR + T + + + + + + T+ ++L+D Sbjct: 72 VVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWD-K 130 Query: 64 NPNPVASFEGHRGNVTSVSFQQ-DNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNE 121 + FEGH V + DN ++S D TIKVW + S S H VN Sbjct: 131 KWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNC 190 Query: 122 VVIH--PNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANT 179 + + ++ LIS D ++IWD C L + S + ++ + Sbjct: 191 IDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQN-VSCASFHPELPIIITGSE 249 Query: 180 KGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTA 231 G +W +S + + + + ++A + + Sbjct: 250 DGTVRIW------HSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSI 295 Score = 127 bits (319), Expect = 6e-30, Method: Composition-based stats. Identities = 35/189 (18%), Positives = 81/189 (42%), Gaps = 9/189 (4%) Query: 3 VILVSAGYDHTIRFWEALT-GVCSRTIQHSDSQVNRLEITN-DKKLLATAG-HQNVRLYD 59 ++++ D I+ W+ CS+ + V ++ I D A+A + ++++ Sbjct: 112 PFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQ 171 Query: 60 IRTTNPNPVASFEGHRGNVTSVSFQQDN--RWMVTSSEDGTIKVWDVRSPSIPRNY-KHN 116 + +++PN + EGH V + + ++++ ++D +K+WD ++ + + H Sbjct: 172 LGSSSPN--FTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHA 229 Query: 117 APVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAA 176 V+ HP +I+ DG +RIW + L + S+ + +A Sbjct: 230 QNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNN-VAL 288 Query: 177 ANTKGNCYV 185 +G+ V Sbjct: 289 GYDEGSIIV 297 Score = 114 bits (284), Expect = 7e-26, Method: Composition-based stats. Identities = 43/233 (18%), Positives = 83/233 (35%), Gaps = 20/233 (8%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKK---LLATAGHQNVRLYDIR 61 SA D TI+ W+ + + T++ + VN ++ + L++ A + V+++D + Sbjct: 158 FASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQ 217 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAP-VN 120 N V + EGH NV+ SF + ++T SEDGT+++W + + + V Sbjct: 218 --NKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVW 275 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 V ++ D I LG + + S ++ A +T Sbjct: 276 CVA-SLRGSNNVALGYDEGSIIVKLGREEPAMSMDANGKIIWAKHSEVQQANLKAMGDT- 333 Query: 181 GNCYVWEMPNHTDASHLKPVTKFRAHSTYIT--RILLSSDVKHLATCSADHTA 231 P+ S I I + + + + C Sbjct: 334 ----------EIKDGERLPLAVKDMGSCEIYPQTIQHNPNGRFVVVCGDGEYI 376 Score = 40.8 bits (94), Expect = 7e-04, Method: Composition-based stats. Identities = 6/50 (12%), Positives = 19/50 (38%) Query: 240 FKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYG 289 ++ L V +++ + + V +W+ T+ +V+ + Sbjct: 5 LDIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFE 54 >5OPT-p nrPDB Length = 318 Score = 186 bits (471), Expect = 1e-47, Method: Composition-based stats. Identities = 62/297 (20%), Positives = 129/297 (43%), Gaps = 33/297 (11%) Query: 6 VSAGYDHTIRFW---------EALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQ-NV 55 VS D+T+ W E G R ++ + V+ + ++N+ +A ++ Sbjct: 32 VSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAFVSDVALSNNGDFAVSASWDHSL 91 Query: 56 RLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK- 114 RL++++T F GH +V SV+F DNR +V+ D ++VW+V Sbjct: 92 RLWNLQTG--VCQHKFLGHTKDVLSVTFSPDNRQIVSGGRDNALRVWNV-KGECLHTLGR 148 Query: 115 --HNAPVNEVVIHP--NQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASD 170 H V+ V P ++S D +++WD+ + L + + S++++ D Sbjct: 149 GAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASGRLLTDLKGHTNY-ITSVTVSPD 207 Query: 171 GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHT 230 GS+ A+++ G +W++ S + I +I S + ++ + + Sbjct: 208 GSLCASSDKDGVARLWDLTKGEALSEMAA-------GAPINQICFSPN-RYWMCAATEKG 259 Query: 231 ARVWSIDD-DFKLETTLDGHQR-----WVWDCAFSADSAYLVTASSDHYVRLWDLST 281 R++ +++ D +E + Q+ A+SAD L + +D+ +R+W +S Sbjct: 260 IRIFDLENKDVIVELAPEAQQKSKKTPECMSIAWSADGNTLYSGYTDNVIRVWSVSE 316 Score = 159 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 49/266 (18%), Positives = 115/266 (43%), Gaps = 22/266 (8%) Query: 31 SDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPN---PVASFEGHRGNVTSVSFQQDN 87 +++ + + + D L+A + D + P EGH V+ V+ + Sbjct: 25 TETYIKAVSTSRDNTLIAWGSN-----MDRNSEECEYGFPERRLEGHSAFVSDVALSNNG 79 Query: 88 RWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLG 146 + V++S D ++++W++++ + H V V P+ +++S RD +R+W++ Sbjct: 80 DFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQIVSGGRDNALRVWNVK 139 Query: 147 ENQCTHQL-TPEDDTSLQSLSMAS--DGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKF 203 +C H L + + + + ++ + VW++ + + +T Sbjct: 140 -GECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASG------RLLTDL 192 Query: 204 RAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSA 263 + H+ YIT + +S D A+ D AR+W + L G + FS + Sbjct: 193 KGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAG--APINQICFSPN-R 249 Query: 264 YLVTASSDHYVRLWDLSTREIVRQYG 289 Y + A+++ +R++DL ++++ + Sbjct: 250 YWMCAATEKGIRIFDLENKDVIVELA 275 Score = 143 bits (361), Expect = 8e-35, Method: Composition-based stats. Identities = 55/247 (22%), Positives = 103/247 (41%), Gaps = 23/247 (9%) Query: 71 FEGHRGNVTSVSFQQDNR---WMVTSSEDGTIKVW----DVRSPSI------PRNYKHNA 117 +GHRG VT+++ Q V++S D T+ W D S R H+A Sbjct: 9 LKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSA 68 Query: 118 PVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAA 177 V++V + N +S D ++R+W+L C H+ + S++ + D + + Sbjct: 69 FVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTK-DVLSVTFSPDNRQIVSG 127 Query: 178 NTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVK--HLATCSADHTARVWS 235 VW + + + AH+ +++ + S ++ + + D+ +VW Sbjct: 128 GRDNALRVWNVKGECLHTLGR-----GAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWD 182 Query: 236 IDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQY-GGHHKG 294 I +L T L GH ++ S D + ++ D RLWDL+ E + + G Sbjct: 183 IASG-RLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPIN 241 Query: 295 AVCVALN 301 +C + N Sbjct: 242 QICFSPN 248 Score = 134 bits (337), Expect = 5e-32, Method: Composition-based stats. Identities = 49/198 (24%), Positives = 87/198 (43%), Gaps = 15/198 (7%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQ--HSDSQVNRLEITN--DKKLLATAGHQN-VRLYD 59 +VS G D+ +R W G C T+ V+ + + + L+ + G N V+++D Sbjct: 124 IVSGGRDNALRVWNV-KGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWD 182 Query: 60 IRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPV 119 I + + +GH +TSV+ D +S +DG ++WD+ AP+ Sbjct: 183 IASGR--LLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPI 240 Query: 120 NEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPE------DDTSLQSLSMASDGSM 173 N++ PN+ + + G IRI+DL +L PE S++ ++DG+ Sbjct: 241 NQICFSPNRYWMCAATEKG-IRIFDLENKDVIVELAPEAQQKSKKTPECMSIAWSADGNT 299 Query: 174 LAAANTKGNCYVWEMPNH 191 L + T VW + H Sbjct: 300 LYSGYTDNVIRVWSVSEH 317 Score = 112 bits (280), Expect = 2e-25, Method: Composition-based stats. Identities = 34/203 (16%), Positives = 76/203 (37%), Gaps = 21/203 (10%) Query: 114 KHNAPVNEVVIHPNQG----ELISCDRDGNIRIW----DLGENQCTHQL----TPEDDTS 161 H V + P + +S RD + W D +C + Sbjct: 11 GHRGWVTALA-CPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAF 69 Query: 162 LQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKH 221 + ++++++G +A+ + +W + KF H+ + + S D + Sbjct: 70 VSDVALSNNGDFAVSASWDHSLRLWNL------QTGVCQHKFLGHTKDVLSVTFSPDNRQ 123 Query: 222 LATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSA--DSAYLVTASSDHYVRLWDL 279 + + D+ RVW++ + H WV FS ++ +V+ D+ V++WD+ Sbjct: 124 IVSGGRDNALRVWNVKGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDI 183 Query: 280 STREIVRQYGGHHKGAVCVALND 302 ++ ++ GH V ++ Sbjct: 184 ASGRLLTDLKGHTNYITSVTVSP 206 Score = 88.2 bits (217), Expect = 3e-18, Method: Composition-based stats. Identities = 28/155 (18%), Positives = 64/155 (41%), Gaps = 13/155 (8%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNV-RLYDI 60 + ++VS G+D+ ++ W+ +G ++ + + + ++ D L A++ V RL+D+ Sbjct: 166 TPLIVSGGWDNLVKVWDIASGRLLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDL 225 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNA--- 117 + + + F + WM ++E G I+++D+ + + A Sbjct: 226 TKGEALSEMAA---GAPINQICFSPNRYWMCAATEKG-IRIFDLENKDVIVELAPEAQQK 281 Query: 118 -----PVNEVVIHPNQGELISCDRDGNIRIWDLGE 147 + + L S D IR+W + E Sbjct: 282 SKKTPECMSIAWSADGNTLYSGYTDNVIRVWSVSE 316 Score = 75.5 bits (184), Expect = 3e-14, Method: Composition-based stats. Identities = 29/113 (25%), Positives = 49/113 (43%), Gaps = 11/113 (9%) Query: 201 TKFRAHSTYITRILLSSDVK---HLATCSADHTARVWSIDDDFK--------LETTLDGH 249 + + H ++T + + + S D+T W + D E L+GH Sbjct: 7 GQLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGH 66 Query: 250 QRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 +V D A S + + V+AS DH +RLW+L T ++ GH K + V + Sbjct: 67 SAFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSP 119 >4V8M-A7 nrPDB Length = 318 Score = 184 bits (468), Expect = 3e-47, Method: Composition-based stats. Identities = 62/298 (20%), Positives = 129/298 (43%), Gaps = 33/298 (11%) Query: 5 LVSAGYDHTIRFW---------EALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQ-N 54 +VS D T+ W E G+ R ++ + V+ + ++N+ +A + Sbjct: 31 VVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSAFVSDVALSNNGNFAVSASWDHS 90 Query: 55 VRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK 114 +RL++++ N F GH +V SV+F DNR +V+ D ++VW+V Sbjct: 91 LRLWNLQ--NGQCQYKFLGHTKDVLSVAFSPDNRQIVSGGRDNALRVWNV-KGECMHTLS 147 Query: 115 ---HNAPVNEVVIHP--NQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMAS 169 H V+ V P + ++S D +++WDL + L + + S++++ Sbjct: 148 RGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGRLVTDLKGHTNY-VTSVTVSP 206 Query: 170 DGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADH 229 DGS+ A+++ G +W++ S + I +I S + ++ + + Sbjct: 207 DGSLCASSDKDGVARLWDLTKGEALSEMAA-------GAPINQICFSPN-RYWMCAATEK 258 Query: 230 TARVWSIDDDFKLETTLDGHQR------WVWDCAFSADSAYLVTASSDHYVRLWDLST 281 R++ +++ + HQ A+SAD + L + +D+ +R+W +S Sbjct: 259 GIRIFDLENKDIIVELAPEHQGSKKIVPECVSIAWSADGSTLYSGYTDNVIRVWGVSE 316 Score = 165 bits (418), Expect = 2e-41, Method: Composition-based stats. Identities = 58/293 (19%), Positives = 124/293 (42%), Gaps = 30/293 (10%) Query: 28 IQHSDSQVNRLEITNDK----KLLATAGHQNVRLYDIRTTNP-------NPVASFEGHRG 76 + V L K+++T+ + + + P EGH Sbjct: 9 LTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSA 68 Query: 77 NVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQGELISCD 135 V+ V+ + + V++S D ++++W++++ + H V V P+ +++S Sbjct: 69 FVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQIVSGG 128 Query: 136 RDGNIRIWDLGENQCTHQLT---PEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHT 192 RD +R+W++ +C H L+ D S S + D ++ + VW++ Sbjct: 129 RDNALRVWNVK-GECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDL---- 183 Query: 193 DASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRW 252 + + VT + H+ Y+T + +S D A+ D AR+W + L G Sbjct: 184 --ATGRLVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAG--AP 239 Query: 253 VWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAV-----CVAL 300 + FS + Y + A+++ +R++DL ++I+ + H+G+ CV++ Sbjct: 240 INQICFSPN-RYWMCAATEKGIRIFDLENKDIIVELAPEHQGSKKIVPECVSI 291 Score = 146 bits (369), Expect = 1e-35, Method: Composition-based stats. Identities = 54/239 (22%), Positives = 101/239 (42%), Gaps = 9/239 (3%) Query: 6 VSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQN-VRLYDIRTTN 64 VSA +DH++R W G C V + + D + + + G N +R+++++ Sbjct: 83 VSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQIVSGGRDNALRVWNVK-GE 141 Query: 65 PNPVASFEGHRGNVTSVSFQQ--DNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNE 121 S H V+ V F D +V+ D +KVWD+ + + + K H V Sbjct: 142 CMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGRLVTDLKGHTNYVTS 201 Query: 122 VVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKG 181 V + P+ S D+DG R+WDL + + ++ + + + + + AA KG Sbjct: 202 VTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAA--GAPINQICFSPNRYWMCAATEKG 259 Query: 182 NCYVWEMPNHTDASHLKPVTKF-RAHSTYITRILLSSDVKHLATCSADHTARVWSIDDD 239 ++++ N L P + + I S+D L + D+ RVW + ++ Sbjct: 260 -IRIFDLENKDIIVELAPEHQGSKKIVPECVSIAWSADGSTLYSGYTDNVIRVWGVSEN 317 Score = 120 bits (302), Expect = 6e-28, Method: Composition-based stats. Identities = 37/206 (17%), Positives = 83/206 (40%), Gaps = 21/206 (10%) Query: 111 RNYKHNAPVNEVVIHPNQG----ELISCDRDGNIRIWDLGENQCTHQLTPE--------D 158 + H V + P +++S RD + W ++ + + + Sbjct: 8 QLTGHRGWVTSLA-CPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGH 66 Query: 159 DTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSD 218 + ++++++G+ +A+ + +W + N + KF H+ + + S D Sbjct: 67 SAFVSDVALSNNGNFAVSASWDHSLRLWNLQNG------QCQYKFLGHTKDVLSVAFSPD 120 Query: 219 VKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSA--DSAYLVTASSDHYVRL 276 + + + D+ RVW++ + + H WV FS D+ +V+ D+ V++ Sbjct: 121 NRQIVSGGRDNALRVWNVKGECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKV 180 Query: 277 WDLSTREIVRQYGGHHKGAVCVALND 302 WDL+T +V GH V ++ Sbjct: 181 WDLATGRLVTDLKGHTNYVTSVTVSP 206 Score = 89.7 bits (221), Expect = 1e-18, Method: Composition-based stats. Identities = 32/156 (20%), Positives = 66/156 (42%), Gaps = 13/156 (8%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNV-RLYDI 60 + ++VS G+D+ ++ W+ TG ++ + V + ++ D L A++ V RL+D+ Sbjct: 166 APVIVSGGWDNLVKVWDLATGRLVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDL 225 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY--KHNAP 118 + + + F + WM ++E G I+++D+ + I +H Sbjct: 226 TKGEALSEMAA---GAPINQICFSPNRYWMCAATEKG-IRIFDLENKDIIVELAPEHQGS 281 Query: 119 VN------EVVIHPNQGELISCDRDGNIRIWDLGEN 148 + + L S D IR+W + EN Sbjct: 282 KKIVPECVSIAWSADGSTLYSGYTDNVIRVWGVSEN 317 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 21/114 (18%), Positives = 33/114 (28%), Gaps = 54/114 (47%) Query: 243 ETTLDGHQRWVWDCA----------------------FSAD------------------- 261 E L GH+ WV A + + Sbjct: 6 EGQLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEG 65 Query: 262 -------------SAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 + V+AS DH +RLW+L + ++ GH K + VA + Sbjct: 66 HSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSP 119 >5WYK-BB nrPDB Length = 943 Score = 182 bits (463), Expect = 1e-46, Method: Composition-based stats. Identities = 59/290 (20%), Positives = 123/290 (42%), Gaps = 28/290 (9%) Query: 28 IQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDN 87 +Q + V ++I++D KLLATA + ++++++I+T + +FE G + F Sbjct: 387 LQGQRTDVRSIDISDDNKLLATASNGSLKIWNIKT--HKCIRTFEC--GYALTCKFLPGG 442 Query: 88 RWMVTSSEDGTIKVWDVRSPSIPRNYK--HNAPVNEVVIHPNQGELISCDRDGNIRIWDL 145 ++ + +G ++++D+ S S+ + H+A + + + + L++ D ++ WD Sbjct: 443 LLVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDF 502 Query: 146 G---------ENQCTHQLTPEDDT------SLQSLSMASDGSMLAAANTKGNCYVWEMPN 190 +N+ L DT + + ++ D LA + V+ + + Sbjct: 503 KVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTVKVFFLDS 562 Query: 191 HTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQ 250 +K H + I +S D K + T SAD ++W +D +L HQ Sbjct: 563 ------MKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFG-DCHKSLFAHQ 615 Query: 251 RWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVAL 300 + + F S + S D V+ WD E +++ H +A+ Sbjct: 616 DSIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQKLYAHQSEVWALAV 665 Score = 127 bits (319), Expect = 5e-30, Method: Composition-based stats. Identities = 48/253 (18%), Positives = 103/253 (40%), Gaps = 24/253 (9%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQ-HSDSQVNRLEITNDKK-LLATAGHQNVRLYDIR 61 +++ + ++ ++ + TI+ D+ + L++T+D K L+ + + V+ +D + Sbjct: 444 LVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFK 503 Query: 62 TTNPNPVAS-------FEGH-------RGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSP 107 N + + H ++ V D+R++ S D T+KV+ + S Sbjct: 504 VENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTVKVFFLDSM 563 Query: 108 SI-PRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLS 166 Y H PV + I + +I+ D NI+IW L C L D S+ ++ Sbjct: 564 KFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKSLFAHQD-SIMNVK 622 Query: 167 MASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCS 226 + + W+ + + K AH + + + +++D + + S Sbjct: 623 FLPQSHNFFSCSKDAVVKYWDGEK------FECIQKLYAHQSEVWALAVATDGGFVVSSS 676 Query: 227 ADHTARVWSIDDD 239 DH+ R+W +D Sbjct: 677 HDHSIRIWEETED 689 Score = 102 bits (254), Expect = 2e-22, Method: Composition-based stats. Identities = 52/260 (20%), Positives = 94/260 (36%), Gaps = 29/260 (11%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQ------------HSDSQVNRLEITNDKKLLATA- 50 ++ SA D + W+ TG + ++ LE D LLA Sbjct: 41 LITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLAVGY 98 Query: 51 GHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS-I 109 ++++D+ + + +F GH+ +T + F +++ S+D I VWD+ + Sbjct: 99 ADGVIKVWDLMS--KTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGEVGL 156 Query: 110 PRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMAS 169 + H + + LIS +DG I++WDL +QC L++ Sbjct: 157 YKLRSHKDSITGF-WCQGEDWLISTSKDGMIKLWDLKTHQCIETHIAHTG-ECWGLAVKD 214 Query: 170 DGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTY------ITRILLSSD-VKHL 222 D +L T +W++ D K I I SSD Sbjct: 215 D--LLITTGTDSQVKIWKLDIENDKMGGKLTEMGIFEKQSKQRGLKIEFITNSSDKTSFF 272 Query: 223 ATCSADHTARVWSIDDDFKL 242 +AD T + I + ++ Sbjct: 273 YIQNADKTIETFRIRKEEEI 292 Score = 96.7 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 39/213 (18%), Positives = 71/213 (33%), Gaps = 26/213 (12%) Query: 84 QQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKH-------------NAPVNEVVIHPNQGE 130 + + ++ ED + +WD+++ + A + H + Sbjct: 36 SGPGQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDL 93 Query: 131 LISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPN 190 L DG I++WDL ++ L G+ L + + N VW++ Sbjct: 94 LAVGYADGVIKVWDLMSKTVLLNFNGHK-AAITLLQFDGTGTRLISGSKDSNIIVWDLVG 152 Query: 191 HTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQ 250 + K R+H IT L + S D ++W + + T H Sbjct: 153 EVG------LYKLRSHKDSITGFWC-QGEDWLISTSKDGMIKLWDLKT-HQCIETHIAHT 204 Query: 251 RWVWDCAFSADSAYLVTASSDHYVRLWDLSTRE 283 W A D L+T +D V++W L Sbjct: 205 GECWGLAVKDD--LLITTGTDSQVKIWKLDIEN 235 Score = 96.3 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 37/186 (19%), Positives = 64/186 (34%), Gaps = 21/186 (11%) Query: 128 QGELISCDRDGNIRIWDLGENQCTHQLT-----------PEDDTSLQSLSMASDGSMLAA 176 + S D + IWD+ +L+ L D +LA Sbjct: 39 GQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLAV 96 Query: 177 ANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI 236 G VW++ + T + F H IT + L + S D VW + Sbjct: 97 GYADGVIKVWDLMSKTVLLN------FNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDL 150 Query: 237 DDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAV 296 + L L H+ + + +L++ S D ++LWDL T + + + H Sbjct: 151 VGEVGLYK-LRSHKDSITG-FWCQGEDWLISTSKDGMIKLWDLKTHQCIETHIAHTGECW 208 Query: 297 CVALND 302 +A+ D Sbjct: 209 GLAVKD 214 Score = 95.9 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 30/150 (20%), Positives = 71/150 (47%), Gaps = 4/150 (2%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKK-LLATAGHQNVRLYDIR 61 L + D+T++ + + ++ V ++I+ D K ++ ++ +N++++ + Sbjct: 544 RYLAISLLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLD 603 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRS-PSIPRNYKHNAPVN 120 + + S H+ ++ +V F + + S+D +K WD I + Y H + V Sbjct: 604 FGDCH--KSLFAHQDSIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQKLYAHQSEVW 661 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQC 150 + + + G ++S D +IRIW+ E+Q Sbjct: 662 ALAVATDGGFVVSSSHDHSIRIWEETEDQV 691 Score = 88.2 bits (217), Expect = 4e-18, Method: Composition-based stats. Identities = 35/201 (17%), Positives = 74/201 (36%), Gaps = 24/201 (11%) Query: 116 NAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLA 175 V + I + +L++ +G+++IW++ ++C + G ++ Sbjct: 391 RTDVRSIDIS-DDNKLLATASNGSLKIWNIKTHKCIRTFECG---YALTCKFLPGGLLVI 446 Query: 176 AANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWS 235 G ++++ + + ++ AH I + L+SD K L T SAD T + W Sbjct: 447 LGTRNGELQLFDLASSSLLDTIE-----DAHDAAIWSLDLTSDGKRLVTGSADKTVKFWD 501 Query: 236 ID--------DDFKLETTLDGH-------QRWVWDCAFSADSAYLVTASSDHYVRLWDLS 280 K L H + S D YL + D+ V+++ L Sbjct: 502 FKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTVKVFFLD 561 Query: 281 TREIVRQYGGHHKGAVCVALN 301 + + GH + + ++ Sbjct: 562 SMKFYLSLYGHKLPVLSIDIS 582 Score = 83.2 bits (204), Expect = 1e-16, Method: Composition-based stats. Identities = 17/109 (15%), Positives = 46/109 (42%), Gaps = 3/109 (2%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDK-KLLATAGHQNVRLYDI 60 S +++++ D I+ W G C +++ + ++ + + V+ +D Sbjct: 585 SKMIITSSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQSHNFFSCSKDAVVKYWD- 643 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSI 109 + H+ V +++ D ++V+SS D +I++W+ + Sbjct: 644 -GEKFECIQKLYAHQSEVWALAVATDGGFVVSSSHDHSIRIWEETEDQV 691 Score = 67.4 bits (163), Expect = 8e-12, Method: Composition-based stats. Identities = 25/137 (18%), Positives = 44/137 (32%), Gaps = 9/137 (6%) Query: 168 ASDGSMLAAANTKGNCYVWEMPNHTDASHL------KPVTKFRAHSTYITRILLSSDVKH 221 + G ++ +A +W++ S L A T + D Sbjct: 36 SGPGQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDL 93 Query: 222 LATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLST 281 LA AD +VW + L +GH+ + F L++ S D + +WDL Sbjct: 94 LAVGYADGVIKVWDLMSKTVLLN-FNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVG 152 Query: 282 REIVRQYGGHHKGAVCV 298 + + H Sbjct: 153 EVGLYKLRSHKDSITGF 169 Score = 48.5 bits (114), Expect = 3e-06, Method: Composition-based stats. Identities = 14/97 (14%), Positives = 31/97 (31%), Gaps = 13/97 (13%) Query: 216 SSDVKHLATCSADHTARVWSIDDDFKLETTLDG-----------HQRWVWDCAFSADSAY 264 S + + + D +W I + DG D+ Sbjct: 36 SGPGQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDL 93 Query: 265 LVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 L +D +++WDL ++ ++ + GH + + Sbjct: 94 LAVGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFD 130 >6EOJ-D nrPDB Length = 470 Score = 180 bits (456), Expect = 8e-46, Method: Composition-based stats. Identities = 49/277 (17%), Positives = 110/277 (39%), Gaps = 11/277 (3%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRTT 63 LV A Y W A + +Q DS V ++ ++D + + ++++ + Sbjct: 108 LVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFS 167 Query: 64 NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEV 122 + + H ++ ++F ++ VT S+D +K+W+ + R H+ V Sbjct: 168 MVKEIDA--AHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSC 225 Query: 123 VIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGN 182 HP G + S +D +++WD C + T L++ + G++L A + + Sbjct: 226 DWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKS 285 Query: 183 CYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDF-- 240 C V+++ +K + R + Y+T + D + + + + + Sbjct: 286 CRVFDIR-----YSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNE 340 Query: 241 KLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 + T H + + +++ TA+ D +R W Sbjct: 341 PILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 Score = 114 bits (285), Expect = 5e-26, Method: Composition-based stats. Identities = 34/208 (16%), Positives = 78/208 (37%), Gaps = 10/208 (4%) Query: 75 RGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGELIS 133 + + ++ + + R +V ++ G +W+ S + + H++ V + + +IS Sbjct: 93 KHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMIS 152 Query: 134 CDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTD 193 D DG I+IW ++ S++ ++ +S+ S + +W N Sbjct: 153 GDADGMIKIWQPN-FSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNG-- 209 Query: 194 ASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWV 253 K H + ++ +A+ S D+ ++W + + L + V Sbjct: 210 ----KQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILK-FKHTV 264 Query: 254 WDCAFSA-DSAYLVTASSDHYVRLWDLS 280 F L+ S D R++D+ Sbjct: 265 LKTRFQPTKGNLLMAISKDKSCRVFDIR 292 Score = 112 bits (281), Expect = 1e-25, Method: Composition-based stats. Identities = 35/167 (20%), Positives = 68/167 (40%), Gaps = 8/167 (4%) Query: 119 VNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAAN 178 + + P L+ G +W+ L D+++ ++ + D + + + Sbjct: 96 IPAIQWTPEGRRLVVATYSGEFSLWNASSFTF-ETLMQAHDSAVTTMKYSHDSDWMISGD 154 Query: 179 TKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDD 238 G +W PN + + AH+ I + SS+ TCS D+ ++W+ + Sbjct: 155 ADGMIKIW-QPNFSMVKEIDA-----AHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSN 208 Query: 239 DFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIV 285 K E L GH V C + + + +AS D+ V+LWD + + Sbjct: 209 G-KQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCI 254 Score = 92.1 bits (227), Expect = 3e-19, Method: Composition-based stats. Identities = 33/145 (22%), Positives = 60/145 (41%), Gaps = 9/145 (6%) Query: 159 DTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSD 218 + ++ +G L A G +W AS T +AH + +T + S D Sbjct: 93 KHVIPAIQWTPEGRRLVVATYSGEFSLWN------ASSFTFETLMQAHDSAVTTMKYSHD 146 Query: 219 VKHLATCSADHTARVWSIDDDFKLETTLDG-HQRWVWDCAFSADSAYLVTASSDHYVRLW 277 + + AD ++W +F + +D H + D AFS++ + VT S D+ +++W Sbjct: 147 SDWMISGDADGMIKIW--QPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIW 204 Query: 278 DLSTREIVRQYGGHHKGAVCVALND 302 + S + R GHH + Sbjct: 205 NFSNGKQERVLSGHHWDVKSCDWHP 229 Score = 76.3 bits (186), Expect = 1e-14, Method: Composition-based stats. Identities = 30/148 (20%), Positives = 64/148 (43%), Gaps = 9/148 (6%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQ--HSDSQVNRLEITNDKKLLATAGHQNVRLYDIR 61 ++ SA D+ ++ W+ +G C +I R + T L+A + ++ R++DIR Sbjct: 233 LIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIR 292 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVT-SSEDGTIKVWD----VRSPSIPRNYKHN 116 + + + + ++ + N M T + DG++K +D + P + Y H+ Sbjct: 293 YSMKELMCVRD--ETDYMTLEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHD 350 Query: 117 APVNEVVIHPNQGELISCDRDGNIRIWD 144 + + +P + +D IR W Sbjct: 351 KCITSLSYNPVGHIFATAAKDRTIRFWT 378 Score = 52.8 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 16/103 (15%), Positives = 40/103 (38%), Gaps = 3/103 (2%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITN--DKKLLATAGHQNVRLYDI 60 +L++ D + R ++ + ++ LE + +++ +D+ Sbjct: 275 NLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFDL 334 Query: 61 RTTNPNPVASF-EGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW 102 P+ + H +TS+S+ T+++D TI+ W Sbjct: 335 LQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 >5Z56-q nrPDB Length = 504 Score = 179 bits (455), Expect = 1e-45, Method: Composition-based stats. Identities = 58/266 (21%), Positives = 103/266 (38%), Gaps = 12/266 (4%) Query: 37 RLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSED 96 L ++ K+L +NV ++D + +A+ +GH VTSV F + ++S D Sbjct: 228 DLCPSDTNKILTGGADKNVVVFDKSSEQ--ILATLKGHTKKVTSVVFHPSQDLVFSASPD 285 Query: 97 GTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLT 155 TI++W V + S + + H + V + +H L+S D D+ + ++T Sbjct: 286 ATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVT 345 Query: 156 PE-DDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRIL 214 E SL DG + +W++ T+ V F HS IT I Sbjct: 346 DETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTN------VANFPGHSGPITSIA 399 Query: 215 LSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYV 274 S + +LAT + D + ++W + +T + V F YL +D + Sbjct: 400 FSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQI 459 Query: 275 RLWDLSTREIVRQYGGHHKGAVCVAL 300 + + + H VA Sbjct: 460 YI--CKQWTEILHFTEHSGLTTGVAF 483 Score = 147 bits (372), Expect = 4e-36, Method: Composition-based stats. Identities = 41/279 (14%), Positives = 103/279 (36%), Gaps = 15/279 (5%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRTT 63 +++ G D + ++ + T++ +V + + L+ +A +R++ + Sbjct: 237 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSV--P 294 Query: 64 NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNA---PVN 120 N + V H VT +S ++++SS+D D+++ + + Sbjct: 295 NASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLT 354 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 HP+ + D I+IWDL E + S++ + +G LA A Sbjct: 355 CAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSG-PITSIAFSENGYYLATAADD 413 Query: 181 GNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDF 240 + +W++ + L+ ++ + ++ +LA D +++ Sbjct: 414 SSVKLWDLRKLKNFKTLQL-----DNNFEVKSLIFDQSGTYLALGGTD--VQIYICKQWT 466 Query: 241 KLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDL 279 ++ H AF + ++ + D ++ + L Sbjct: 467 EILH-FTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504 Score = 147 bits (372), Expect = 4e-36, Method: Composition-based stats. Identities = 50/235 (21%), Positives = 95/235 (40%), Gaps = 10/235 (4%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLY-DIRT 62 ++ SA D TIR W C + ++ +S V L + L ++ + DI+T Sbjct: 278 LVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQT 337 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNE 121 + E ++T F D T + D IK+WD++ + N+ H+ P+ Sbjct: 338 GRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITS 397 Query: 122 VVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKG 181 + N L + D ++++WDL + + L +++ ++SL G+ LA T Sbjct: 398 IAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDV 457 Query: 182 NCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI 236 Y+ + F HS T + K +A+ D + + +S+ Sbjct: 458 QIYI--------CKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504 Score = 105 bits (263), Expect = 2e-23, Method: Composition-based stats. Identities = 37/186 (19%), Positives = 71/186 (38%), Gaps = 9/186 (4%) Query: 119 VNEVVIHP-NQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAA 177 + + + P + ++++ D N+ ++D Q L + S+ ++ +A Sbjct: 224 ILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKK-VTSVVFHPSQDLVFSA 282 Query: 178 NTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSID 237 + +W +PN + V RAH + +T + L + +L + S D I Sbjct: 283 SPDATIRIWSVPNAS------CVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQ 336 Query: 238 DDFKLETTLDGHQRWVWDCA-FSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAV 296 L D CA F D T + D +++WDL R V + GH Sbjct: 337 TGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPIT 396 Query: 297 CVALND 302 +A ++ Sbjct: 397 SIAFSE 402 Score = 77.0 bits (188), Expect = 9e-15, Method: Composition-based stats. Identities = 25/100 (25%), Positives = 40/100 (40%), Gaps = 5/100 (5%) Query: 206 HSTYITRIL----LSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSAD 261 HS I IL SD + T AD V+ + ++ TL GH + V F Sbjct: 217 HSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSE-QILATLKGHTKKVTSVVFHPS 275 Query: 262 SAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 + +AS D +R+W + V+ H ++L+ Sbjct: 276 QDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLH 315 >4BTS-AR nrPDB Length = 343 Score = 179 bits (454), Expect = 1e-45, Method: Composition-based stats. Identities = 60/313 (19%), Positives = 124/313 (39%), Gaps = 44/313 (14%) Query: 2 SVILVSAGYDHTIRFW-------EALTGVCSRTIQHSDSQVNRLEITNDKKL-LATAGHQ 53 S +L+S D T+ W G+ + + + V+ L ++ + ++++ + Sbjct: 39 SPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLALSQENCFAISSSWDK 98 Query: 54 NVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY 113 +RL+D+RT F GH+ V SV+F DNR ++++ + IK+W++ + Sbjct: 99 TLRLWDLRTG--TTYKRFVGHQSEVYSVAFSPDNRQILSAGAEREIKLWNILGECKFSSA 156 Query: 114 K---HNAPVNEVVIH----------PNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDT 160 + H+ V+ V P S DG +++W+ N ++ Sbjct: 157 EKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGRLKVWN--TNFQIRYTFKAHES 214 Query: 161 SLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVK 220 ++ LS++ +G +A +W++ N T P +F A ST I +I + ++ Sbjct: 215 NVNHLSISPNGKYIATGGKDKKLLIWDILNLTY-----PQREFDAGST-INQIAFNPKLQ 268 Query: 221 HLATCSADHTARVWSIDDDFKLET------------TLDGHQRWVWDCAFSADSAYLVTA 268 +A D +++++ K G A++A L Sbjct: 269 WVAVG-TDQGVKIFNLMTQSKAPVCTIEAEPITKAEGQKGKNPQCTSLAWNALGKKLFAG 327 Query: 269 SSDHYVRLWDLST 281 +D +R + T Sbjct: 328 FTDGVIRTFSFET 340 Score = 132 bits (332), Expect = 2e-31, Method: Composition-based stats. Identities = 47/256 (18%), Positives = 99/256 (38%), Gaps = 31/256 (12%) Query: 71 FEGHRGNVTSVSF------QQDNRWMVTSSEDGTIKVWDV----RSPSIPRNYK----HN 116 EGH VTS+ +D+ +++ S D T+ +W + ++ +K HN Sbjct: 17 LEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHN 76 Query: 117 APVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAA 176 V+++ + IS D +R+WDL + + + S++ + D + + Sbjct: 77 HFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGH-QSEVYSVAFSPDNRQILS 135 Query: 177 ANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVK----------HLATCS 226 A + +W + S + HS +++ + S +K + A+ Sbjct: 136 AGAEREIKLWNILGECKFSSAEK----ENHSDWVSCVRYSPIMKSANKVQPFAPYFASVG 191 Query: 227 ADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVR 286 D +VW+ +F++ T H+ V + S + Y+ T D + +WD+ + Sbjct: 192 WDGRLKVWN--TNFQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKLLIWDILNLTYPQ 249 Query: 287 QYGGHHKGAVCVALND 302 + +A N Sbjct: 250 REFDAGSTINQIAFNP 265 Score = 96.7 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 27/140 (19%), Positives = 57/140 (40%), Gaps = 6/140 (4%) Query: 168 ASDGSMLAAANTKGNCYVWE-MPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCS 226 D +L + + +W+ + P H+ +++ + LS + + S Sbjct: 36 NEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLALSQENCFAISSS 95 Query: 227 ADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIV- 285 D T R+W + + GHQ V+ AFS D+ +++A ++ ++LW++ E Sbjct: 96 WDKTLRLWDLRTGTTYKR-FVGHQSEVYSVAFSPDNRQILSAGAEREIKLWNIL-GECKF 153 Query: 286 --RQYGGHHKGAVCVALNDV 303 + H CV + + Sbjct: 154 SSAEKENHSDWVSCVRYSPI 173 Score = 47.0 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 22/113 (19%), Positives = 30/113 (26%), Gaps = 55/113 (48%) Query: 245 TLDGHQRWVWDC--AFSA----DSAYLVTA------------------------------ 268 L+GH WV FS DS L++ Sbjct: 16 ILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGH 75 Query: 269 -------------------SSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 S D +RLWDL T +++ GH VA + Sbjct: 76 NHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSP 128 >6N9G-C nrPDB Length = 353 Score = 178 bits (452), Expect = 2e-45, Method: Composition-based stats. Identities = 54/281 (19%), Positives = 105/281 (37%), Gaps = 14/281 (4%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNV-----RLYD 59 +VS+ D + W++ T + + V +A G N +D Sbjct: 78 IVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFD 137 Query: 60 IRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAP 118 S H +++ SF + ++T+S DGT +WDV S + +++ H A Sbjct: 138 KNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGAD 197 Query: 119 VNEVVIHP--NQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAA 176 V + + P +S D +WD+ QC ++ + S+ G A+ Sbjct: 198 VLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETH-ESDVNSVRYYPSGDAFAS 256 Query: 177 ANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI 236 + C ++++ + + + + + S + L D+T VW + Sbjct: 257 GSDDATCRLYDLRADREVAIYSKESIIFG----ASSVDFSLSGRLLFAGYNDYTINVWDV 312 Query: 237 DDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 ++ + L GH+ V S D + S DH +R+W Sbjct: 313 LKGSRV-SILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352 Score = 139 bits (351), Expect = 1e-33, Method: Composition-based stats. Identities = 43/287 (14%), Positives = 99/287 (34%), Gaps = 18/287 (6%) Query: 26 RTIQHSDSQVNRLEITNDKK-LLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQ 84 RT++ ++V ++ DK+ +++++ V ++D TTN + V + ++ Sbjct: 57 RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPC--TWVMACAYA 114 Query: 85 QDNRWMVTSSEDGTIKVWDVR-------SPSIPRNYKHNAPVNEVVIHPNQGELISCDRD 137 + D V+ + + H ++ + ++++ D Sbjct: 115 PSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGD 174 Query: 138 GNIRIWDLGENQCTHQLTPED-DTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASH 196 G +WD+ Q D L+ + G+ + VW+M + Sbjct: 175 GTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSG----- 229 Query: 197 LKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTL-DGHQRWVWD 255 + V F H + + + A+ S D T R++ + D ++ + Sbjct: 230 -QCVQAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASS 288 Query: 256 CAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 FS L +D+ + +WD+ V GH + ++ Sbjct: 289 VDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSP 335 Score = 79.7 bits (195), Expect = 1e-15, Method: Composition-based stats. Identities = 22/157 (14%), Positives = 58/157 (36%), Gaps = 11/157 (7%) Query: 151 THQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYI 210 T + + + D + +++ G VW+ + ++ Sbjct: 55 TRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCT------WV 108 Query: 211 TRILLSSDVKHLATCSADHTARVWSI-----DDDFKLETTLDGHQRWVWDCAFSADSAYL 265 + +A D+ V+ + ++ + ++ H ++ C+F+ + Sbjct: 109 MACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQI 168 Query: 266 VTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 +TAS D LWD+ + ++++ + GH +C+ L Sbjct: 169 LTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAP 205 Score = 44.3 bits (103), Expect = 6e-05, Method: Composition-based stats. Identities = 11/57 (19%), Positives = 27/57 (47%), Gaps = 1/57 (1%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKK-LLATAGHQNVRLY 58 +L + D+TI W+ L G + +++V+ L ++ D + + +R++ Sbjct: 296 RLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352 Score = 38.9 bits (89), Expect = 0.002, Method: Composition-based stats. Identities = 13/38 (34%), Positives = 18/38 (47%) Query: 241 KLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWD 278 K TL GH V + D +V++S D V +WD Sbjct: 54 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWD 91 >5GAN-H nrPDB Length = 465 Score = 177 bits (448), Expect = 7e-45, Method: Composition-based stats. Identities = 46/283 (16%), Positives = 111/283 (39%), Gaps = 14/283 (4%) Query: 4 ILVSAGYDHTIRFWEALTGVCS-RTIQHSDSQVNRLEITNDK--KLLATAGHQNVR--LY 58 ++ + + ++ + T + + ++ ++ D ++++ A ++ Y Sbjct: 189 VVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDGLIKNFQY 248 Query: 59 DIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRS-PSIPRNYKHNA 117 + GH ++ V + +++ ++S D T ++WD + + H+ Sbjct: 249 SNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQEGHDK 308 Query: 118 PVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAA 177 V + + + S D +WD+ L + +++ + +G +A Sbjct: 309 GVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSK-PIYTVAWSPNGYQVATG 367 Query: 178 NTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSD--VKHLATCSADHTARVWS 235 G VW++ + + + AH +T++ S + K L +C D+ V+S Sbjct: 368 GGDGIINVWDIRKRDEGQ----LNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYS 423 Query: 236 IDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWD 278 D K +L GH + S +S +LV+ D ++LW+ Sbjct: 424 SDTWLK-MGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465 Score = 147 bits (372), Expect = 5e-36, Method: Composition-based stats. Identities = 57/282 (20%), Positives = 114/282 (40%), Gaps = 18/282 (6%) Query: 31 SDSQVNRLEITNDKKLLATAGH-QNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQD-NR 88 S ++ + ++ D ++AT ++++ + +T P + H G + ++ + D N Sbjct: 174 STKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQP-LTQKLDSHVGKIGAIDWHPDSNN 232 Query: 89 WMVTSSEDGTIKVWDVRSPS-----IPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIW 143 M++ +EDG IK + + + H +++V HP+ + S D R+W Sbjct: 233 QMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLW 292 Query: 144 DLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKF 203 D +Q L D + SLS DGS++ + +W++ + + V Sbjct: 293 DASTHQELL-LQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSK------VMTL 345 Query: 204 RAHSTYITRILLSSDVKHLATCSADHTARVWSIDD-DFKLETTLDGHQRWVWDCAFSAD- 261 HS I + S + +AT D VW I D + H+ V FS + Sbjct: 346 AGHSKPIYTVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKED 405 Query: 262 -SAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 LV+ D+ + ++ T + GH + + +++ Sbjct: 406 GGKKLVSCGYDNLINVYSSDTWLKMGSLAGHTDKIISLDISN 447 Score = 30.4 bits (67), Expect = 0.96, Method: Composition-based stats. Identities = 8/17 (47%), Positives = 11/17 (64%) Query: 2 SVILVSAGYDHTIRFWE 18 S LVS G+D +I+ W Sbjct: 449 SHFLVSGGWDRSIKLWN 465 >5WYJ-BC nrPDB Length = 817 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 66/309 (21%), Positives = 127/309 (41%), Gaps = 34/309 (11%) Query: 18 EALTGVCSRTIQHSDSQVNRLEIT-NDKKLLATAGHQ-NVRLYDI------RTTNPNPVA 69 + T + +I + + + + LA A + ++R+ + + P V Sbjct: 323 DEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIPVPDLSGPEASLPLDVE 382 Query: 70 SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSI-----PRNYKHNAPVNEV-- 122 +EGH + S+ +D W+ T+S+D T VW S + H+A V V Sbjct: 383 IYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGL 442 Query: 123 --VIHPNQGE-LISCDRDGNIRIW---------DLGENQCTHQLTPEDDTSLQSLSMASD 170 ++ E L++ D I+ W D+ + + + + +LS++ + Sbjct: 443 PNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPN 502 Query: 171 GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHT 230 S+ A A+ C +W + N + H + + K LAT S D T Sbjct: 503 DSIFATASYDKTCKIWNLENGELEAT------LANHKRGLWDVSFCQYDKLLATSSGDKT 556 Query: 231 ARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGG 290 ++WS+D F + TL+GH V C+F L++ +D +++WD S+ E ++ G Sbjct: 557 VKIWSLDT-FSVMKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWDCSSGECLKTLDG 615 Query: 291 HHKGAVCVA 299 H+ ++ Sbjct: 616 HNNRLWALS 624 Score = 144 bits (362), Expect = 6e-35, Method: Composition-based stats. Identities = 57/269 (21%), Positives = 104/269 (38%), Gaps = 27/269 (10%) Query: 28 IQHSDSQVNRLEITNDKKLLATAGHQNVRL---YDIRTTNPNPVASFEGHRGNVTSVSFQ 84 + + +N L+ T D +ATA N + Y+ + + A + GH VT+V Sbjct: 384 YEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLP 443 Query: 85 Q-----DNRWMVTSSEDGTIKVWDVRSPSIPRNYK-----------HNAPVNEVVIHPNQ 128 +++T+S D TIK W + P+ + + H +N + + PN Sbjct: 444 NIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPND 503 Query: 129 GELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEM 188 + D +IW+L + L L +S +LA ++ +W + Sbjct: 504 SIFATASYDKTCKIWNLENGELEATLANHK-RGLWDVSFCQYDKLLATSSGDKTVKIWSL 562 Query: 189 PNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDG 248 + L+ H+ + R + K L +C AD ++W + TLDG Sbjct: 563 DTFSVMKTLE------GHTNAVQRCSFINKQKQLISCGADGLIKIWDCSSG-ECLKTLDG 615 Query: 249 HQRWVWDCAFSADSAYLVTASSDHYVRLW 277 H +W + D +V+A +D + W Sbjct: 616 HNNRLWALSTMNDGDMIVSADADGVFQFW 644 Score = 120 bits (302), Expect = 5e-28, Method: Composition-based stats. Identities = 69/384 (17%), Positives = 123/384 (32%), Gaps = 91/384 (23%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEI-------TNDKKLLATAGHQNVR 56 +L S + ++ W+ + C T+Q S V L+I LL+ + Sbjct: 162 LLASGDTNGMVKVWDLVKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIIN 221 Query: 57 LYDIRTTNPNPVASFEGHRGNVTSVSFQQDN---RWMVTSSEDGTIKVWDVRSPSIPRNY 113 L+D + V S F +D R + T+ D ++ D S S+ + Sbjct: 222 LWDFNMKKKCKLLKTLPVNQQVESCGFLKDGDGKRIIYTAGGDAIFQLIDSESGSVLK-- 279 Query: 114 KHNAPV----------------NEVVIHPNQGELISCDRD-----GNIRI---------- 142 + N P+ +V+ +LI+ + D I++ Sbjct: 280 RTNKPIEELFIIGVLPILSNSQMFLVLSDQTLQLINVEEDLKNDEDTIQVTSSIAGNHGI 339 Query: 143 -------------WDLGENQCTHQLTPEDDTSLQSLSMASD------------------- 170 L N + ++ P D S S+ D Sbjct: 340 IADMRYVGPELNKLALATNSPSLRIIPVPDLSGPEASLPLDVEIYEGHEDLLNSLDATED 399 Query: 171 GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSS-----DVKHLATC 225 G +A A+ VW ++ K+ HS +T + L + + L T Sbjct: 400 GLWIATASKDNTAIVWRYNENSC--KFDIYAKYIGHSAAVTAVGLPNIVSKGYPEFLLTA 457 Query: 226 SADHTARVWSIDDDFK---------LETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRL 276 S D T + W I E T H++ + + S + + TAS D ++ Sbjct: 458 SNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDSIFATASYDKTCKI 517 Query: 277 WDLSTREIVRQYGGHHKGAVCVAL 300 W+L E+ H +G V+ Sbjct: 518 WNLENGELEATLANHKRGLWDVSF 541 Score = 120 bits (300), Expect = 9e-28, Method: Composition-based stats. Identities = 39/250 (15%), Positives = 85/250 (34%), Gaps = 28/250 (11%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQ----HSDSQVNRLEITN-----DKKLLATAGHQ-N 54 + +A D+T W C I + V + + N + L TA + Sbjct: 403 IATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPNIVSKGYPEFLLTASNDLT 462 Query: 55 VRLY---------DIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVR 105 ++ + D++ + H ++ ++S ++ T+S D T K+W++ Sbjct: 463 IKKWIIPKPTASMDVQIIKVSEYTR-HAHEKDINALSVSPNDSIFATASYDKTCKIWNLE 521 Query: 106 SPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQS 164 + + H + +V L + D ++IW L L + +Q Sbjct: 522 NGELEATLANHKRGLWDVSFCQYDKLLATSSGDKTVKIWSLDTFSVMKTLEGHTNA-VQR 580 Query: 165 LSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLAT 224 S + L + G +W+ S + + H+ + + +D + + Sbjct: 581 CSFINKQKQLISCGADGLIKIWD------CSSGECLKTLDGHNNRLWALSTMNDGDMIVS 634 Query: 225 CSADHTARVW 234 AD + W Sbjct: 635 ADADGVFQFW 644 Score = 119 bits (297), Expect = 2e-27, Method: Composition-based stats. Identities = 57/329 (17%), Positives = 129/329 (39%), Gaps = 32/329 (9%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDS---QVNRLEITNDKKLLATAGHQNVRLYD 59 I+ +AG D + ++ +G + + L I ++ ++ Q ++L + Sbjct: 256 RIIYTAGGDAIFQLIDSESGSVLKRTNKPIEELFIIGVLPILSNSQMFLVLSDQTLQLIN 315 Query: 60 IRTTNPNPVASFE------GHRGNVTSVSFQ-QDNRWMVTSSEDGTIKVW---DVRSPSI 109 + N + + G+ G + + + + + ++ ++++ D+ P Sbjct: 316 VEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIPVPDLSGPEA 375 Query: 110 PRNY------KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPE---DDT 160 H +N + + + + +D +W EN C + + Sbjct: 376 SLPLDVEIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSA 435 Query: 161 SLQSL---SMASDG--SMLAAANTKGNCYVWEMPNHTDASHLKPV----TKFRAHSTYIT 211 ++ ++ ++ S G L A+ W +P T + ++ + AH I Sbjct: 436 AVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDIN 495 Query: 212 RILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSD 271 + +S + AT S D T ++W++++ +LE TL H+R +WD +F L T+S D Sbjct: 496 ALSVSPNDSIFATASYDKTCKIWNLENG-ELEATLANHKRGLWDVSFCQYDKLLATSSGD 554 Query: 272 HYVRLWDLSTREIVRQYGGHHKGAVCVAL 300 V++W L T +++ GH + Sbjct: 555 KTVKIWSLDTFSVMKTLEGHTNAVQRCSF 583 Score = 109 bits (271), Expect = 2e-24, Method: Composition-based stats. Identities = 47/334 (14%), Positives = 111/334 (33%), Gaps = 34/334 (10%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEIT---NDKKLLATAGHQN--VR 56 S +L G D +I + G + + + ++ L+ N K L +G N V+ Sbjct: 114 STLLAVGGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVK 173 Query: 57 LYDIRTTNPNPVASFEGHRGNVTSVSF------QQDNRWMVTSSEDGTIKVWDVR---SP 107 ++D+ + + + H V + + + +++ D I +WD Sbjct: 174 VWDL--VKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKC 231 Query: 108 SIPRNYKHNAPVNEVVIHPNQ---GELISCDRDGNIRIWDLGENQCTHQLT-PEDDTSLQ 163 + + N V + + + D ++ D + P ++ + Sbjct: 232 KLLKTLPVNQQVESCGFLKDGDGKRIIYTAGGDAIFQLIDSESGSVLKRTNKPIEELFII 291 Query: 164 SLSMASDGSMLAAANTKGNCYVWEMPN--HTDASHLKPVTKFRAHSTYITRILLS-SDVK 220 + S + + + + D ++ + + I + ++ Sbjct: 292 GVLPILSNSQMFLVLSDQTLQLINVEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGPELN 351 Query: 221 HLATCSADHTARVWSIDDDFKLETTL-------DGHQRWVWDCAFSADSAYLVTASSDHY 273 LA + + R+ + D E +L +GH+ + + D ++ TAS D+ Sbjct: 352 KLALATNSPSLRIIPVPDLSGPEASLPLDVEIYEGHEDLLNSLDATEDGLWIATASKDNT 411 Query: 274 VRLWDLSTREI----VRQYGGHHKGAVCVALNDV 303 +W + +Y GH V L ++ Sbjct: 412 AIVWRYNENSCKFDIYAKYIGHSAAVTAVGLPNI 445 Score = 93.6 bits (231), Expect = 9e-20, Method: Composition-based stats. Identities = 48/284 (16%), Positives = 104/284 (36%), Gaps = 24/284 (8%) Query: 19 ALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRG-N 77 + G+ I S V + + + K+LAT + + D+ + + Sbjct: 6 SYKGISLNPIYAGSSAVATV--SENGKILATPVLDEINIIDLTPGSRKILHKISNEDEQE 63 Query: 78 VTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRD 137 +T++ D +++ S+ +K++ +++ + R+ K ++P + L D Sbjct: 64 ITALKLTPDGQYLTYVSQAQLLKIFHLKTGKVVRSMKISSPSYILDADSTSTLLAVGGTD 123 Query: 138 GNIRIWDLGENQCTHQLTPEDDTSLQSLSM----ASDGSMLAAANTKGNCYVWEMPNHTD 193 G+I + D+ TH T + SL S +LA+ +T G VW++ Sbjct: 124 GSIIVVDIENGYITHSFKGHGGT-ISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKR-- 180 Query: 194 ASHLKPVTKFRAHSTYITRILL--SSDVKH----LATCSADHTARVWSID-DDFKLETTL 246 K + + H++ + + + D L + D +W + Sbjct: 181 ----KCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLLKT 236 Query: 247 DGHQRWVWDCAFSADS---AYLVTASSDHYVRLWDLSTREIVRQ 287 + V C F D + TA D +L D + ++++ Sbjct: 237 LPVNQQVESCGFLKDGDGKRIIYTAGGDAIFQLIDSESGSVLKR 280 Score = 89.4 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 19/100 (19%), Positives = 46/100 (46%), Gaps = 3/100 (3%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEI-TNDKKLLATAGHQNVRLYDIRT 62 +L ++ D T++ W T +T++ + V R K+L++ ++++D + Sbjct: 547 LLATSSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWDCSS 606 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW 102 + + +GH + ++S D +V++ DG + W Sbjct: 607 GE--CLKTLDGHNNRLWALSTMNDGDMIVSADADGVFQFW 644 Score = 71.3 bits (173), Expect = 5e-13, Method: Composition-based stats. Identities = 33/190 (17%), Positives = 70/190 (36%), Gaps = 14/190 (7%) Query: 120 NEVVIHPNQGELISCDRDGNIRIWDL--GENQCTHQLTPEDDTSLQSLSMASDGSMLAAA 177 + V G++++ I I DL G + H+++ ED+ + +L + DG L Sbjct: 20 SAVATVSENGKILATPVLDEINIIDLTPGSRKILHKISNEDEQEITALKLTPDGQYLTYV 79 Query: 178 NTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSID 237 + ++ + +K S+ + S LA D + V I+ Sbjct: 80 SQAQLLKIFHLKTGKVVRSMKI-------SSPSYILDADSTSTLLAVGGTDGSIIVVDIE 132 Query: 238 DDFKLETTLDGHQRWVWDCAFSADSA----YLVTASSDHYVRLWDLSTREIVRQYGGHHK 293 + + + + GH + F L + ++ V++WDL R+ + H Sbjct: 133 NGY-ITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQEHTS 191 Query: 294 GAVCVALNDV 303 + + +V Sbjct: 192 AVRGLDIIEV 201 >5UZ7-B nrPDB Length = 351 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 60/281 (21%), Positives = 105/281 (37%), Gaps = 11/281 (3%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNV-RLYDI 60 S +LVSA D + W++ T I S V +A G N+ +Y++ Sbjct: 78 SRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNL 137 Query: 61 RTTNPN--PVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVR-SPSIPRNYKHNA 117 +T N GH G ++ F DN +VTSS D T +WD+ H Sbjct: 138 KTREGNVRVSRELAGHTGYLSCCRFLDDN-QIVTSSGDTTCALWDIETGQQTTTFTGHTG 196 Query: 118 PVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAA 177 V + + P+ +S D + ++WD+ E C T ++ + ++ +G+ A Sbjct: 197 DVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGH-ESDINAICFFPNGNAFATG 255 Query: 178 NTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSID 237 + C ++++ + IT + S + L D VW Sbjct: 256 SDDATCRLFDLRADQELMT----YSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL 311 Query: 238 DDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWD 278 L GH V + D + T S D ++++W+ Sbjct: 312 KA-DRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 351 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 49/286 (17%), Positives = 104/286 (36%), Gaps = 21/286 (7%) Query: 26 RTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQ 84 RT++ +++ + D +LL +A + ++D + N V + V + ++ Sbjct: 60 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD--SYTTNKVHAIPLRSSWVMTCAYA 117 Query: 85 QDNRWMVTSSEDGTIKVWDVRSPS----IPRNY-KHNAPVNEVVIHPNQGELISCDRDGN 139 ++ D ++++++ + R H ++ + ++++ D Sbjct: 118 PSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL-DDNQIVTSSGDTT 176 Query: 140 IRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKP 199 +WD+ Q T T + SLS+A D + + + +W++ Sbjct: 177 CALWDIETGQQTTTFTGHTG-DVMSLSLAPDTRLFVSGACDASAKLWDVREG------MC 229 Query: 200 VTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQR---WVWDC 256 F H + I I + AT S D T R++ + D +L T H + Sbjct: 230 RQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTY--SHDNIICGITSV 287 Query: 257 AFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 +FS L+ D +WD + GH C+ + D Sbjct: 288 SFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTD 333 Score = 82.0 bits (201), Expect = 3e-16, Method: Composition-based stats. Identities = 27/195 (13%), Positives = 58/195 (29%), Gaps = 42/195 (21%) Query: 146 GENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWE------------------ 187 T + + ++ +D +L +A+ G +W+ Sbjct: 53 RIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVM 112 Query: 188 ----------------------MPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATC 225 T +++ + H+ Y++ D + T Sbjct: 113 TCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF-LDDNQIVTS 171 Query: 226 SADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIV 285 S D T +W I+ + T H V + + D+ V+ + D +LWD+ Sbjct: 172 SGDTTCALWDIETGQQTTTFTG-HTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR 230 Query: 286 RQYGGHHKGAVCVAL 300 + + GH + Sbjct: 231 QTFTGHESDINAICF 245 Score = 64.7 bits (156), Expect = 4e-11, Method: Composition-based stats. Identities = 24/111 (21%), Positives = 41/111 (36%), Gaps = 5/111 (4%) Query: 196 HLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWD 255 ++ R H I + +D + L + S D +W K+ WV Sbjct: 55 QMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAI-PLRSSWVMT 113 Query: 256 CAFSADSAYLVTASSDHYVRLWDLSTRE----IVRQYGGHHKGAVCVALND 302 CA++ Y+ D+ +++L TRE + R+ GH C D Sbjct: 114 CAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLD 164 >4LG8-A nrPDB Length = 354 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 58/266 (21%), Positives = 103/266 (38%), Gaps = 12/266 (4%) Query: 37 RLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSED 96 L ++ K+L +NV ++D + +A+ +GH VTSV F + ++S D Sbjct: 78 DLCPSDTNKILTGGADKNVVVFDKSSEQ--ILATLKGHTKKVTSVVFHPSQDLVFSASPD 135 Query: 97 GTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLT 155 TI++W V + S + + H + V + +H L+S D D+ + ++T Sbjct: 136 ATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVT 195 Query: 156 PE-DDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRIL 214 E SL DG + +W++ T+ V F HS IT I Sbjct: 196 DETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTN------VANFPGHSGPITSIA 249 Query: 215 LSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYV 274 S + +LAT + D + ++W + +T + V F YL +D + Sbjct: 250 FSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQI 309 Query: 275 RLWDLSTREIVRQYGGHHKGAVCVAL 300 + + + H VA Sbjct: 310 YI--CKQWTEILHFTEHSGLTTGVAF 333 Score = 142 bits (358), Expect = 2e-34, Method: Composition-based stats. Identities = 50/235 (21%), Positives = 95/235 (40%), Gaps = 10/235 (4%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLY-DIRT 62 ++ SA D TIR W C + ++ +S V L + L ++ + DI+T Sbjct: 128 LVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQT 187 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNE 121 + E ++T F D T + D IK+WD++ + N+ H+ P+ Sbjct: 188 GRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITS 247 Query: 122 VVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKG 181 + N L + D ++++WDL + + L +++ ++SL G+ LA T Sbjct: 248 IAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDV 307 Query: 182 NCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI 236 Y+ + F HS T + K +A+ D + + +S+ Sbjct: 308 QIYI--------CKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 354 Score = 142 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 41/279 (14%), Positives = 103/279 (36%), Gaps = 15/279 (5%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRTT 63 +++ G D + ++ + T++ +V + + L+ +A +R++ + Sbjct: 87 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSV--P 144 Query: 64 NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNA---PVN 120 N + V H VT +S ++++SS+D D+++ + + Sbjct: 145 NASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLT 204 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 HP+ + D I+IWDL E + S++ + +G LA A Sbjct: 205 CAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSG-PITSIAFSENGYYLATAADD 263 Query: 181 GNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDF 240 + +W++ + L+ ++ + ++ +LA D +++ Sbjct: 264 SSVKLWDLRKLKNFKTLQL-----DNNFEVKSLIFDQSGTYLALGGTD--VQIYICKQWT 316 Query: 241 KLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDL 279 ++ H AF + ++ + D ++ + L Sbjct: 317 EILH-FTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 354 Score = 102 bits (253), Expect = 3e-22, Method: Composition-based stats. Identities = 37/186 (19%), Positives = 71/186 (38%), Gaps = 9/186 (4%) Query: 119 VNEVVIHP-NQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAA 177 + + + P + ++++ D N+ ++D Q L + S+ ++ +A Sbjct: 74 ILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKK-VTSVVFHPSQDLVFSA 132 Query: 178 NTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSID 237 + +W +PN + V RAH + +T + L + +L + S D I Sbjct: 133 SPDATIRIWSVPNAS------CVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQ 186 Query: 238 DDFKLETTLDGHQRWVWDCA-FSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAV 296 L D CA F D T + D +++WDL R V + GH Sbjct: 187 TGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPIT 246 Query: 297 CVALND 302 +A ++ Sbjct: 247 SIAFSE 252 Score = 74.3 bits (181), Expect = 6e-14, Method: Composition-based stats. Identities = 25/100 (25%), Positives = 40/100 (40%), Gaps = 5/100 (5%) Query: 206 HSTYITRIL----LSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSAD 261 HS I IL SD + T AD V+ + ++ TL GH + V F Sbjct: 67 HSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSE-QILATLKGHTKKVTSVVFHPS 125 Query: 262 SAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 + +AS D +R+W + V+ H ++L+ Sbjct: 126 QDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLH 165 >4YCZ-A nrPDB Length = 876 Score = 169 bits (428), Expect = 1e-42, Method: Composition-based stats. Identities = 55/294 (18%), Positives = 108/294 (36%), Gaps = 34/294 (11%) Query: 29 QHSDSQVNRLEITNDKK-LLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQD- 86 D ++ + + L + + +++++I + +GH G V VS+ Sbjct: 15 SGHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPK 74 Query: 87 -NRWMVTSSEDGTIKVWDVRSPSIPRNYK---HNAPVNEVVIHPNQ-GELISC-DRDGNI 140 + ++ DG + +W + + R + H A VN V P++ G L++C DGN+ Sbjct: 75 YGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNV 134 Query: 141 RIWDLGENQCTHQLTPEDDTSLQSLSMASDGS-----------------MLAAANTKGNC 183 + + +N H + + S+S A S + Sbjct: 135 SVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNAL 194 Query: 184 YVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDV---KHLATCSADHTARVWSIDDDF 240 +W T+ L+ H+ ++ + S V ++A+ S D T R+W+ D Sbjct: 195 KIWAYDPATNTYKLER-EPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPAN 253 Query: 241 KLE--TTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWD---LSTREIVRQYG 289 L+ + VW ++S L + D+ V LW E V+ Sbjct: 254 PLQWNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVTLWKENLKGEWECVKTIE 307 Score = 104 bits (260), Expect = 4e-23, Method: Composition-based stats. Identities = 52/233 (22%), Positives = 81/233 (34%), Gaps = 34/233 (14%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQH--SDSQVNRLEITN--DKKLLATAG-HQNVRL 57 IL SAGYD + W L G R + VN + + LLA A NV + Sbjct: 77 NILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNVSV 136 Query: 58 YDIRTTNPNPVASFEGHRGNVTSVSFQQ-----------------DNRWMVTSSEDGTIK 100 + R N + F H V SVS+ NR VT D +K Sbjct: 137 LEFR-DNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNALK 195 Query: 101 VWDVRSPSIPRNY------KHNAPVNEVVIHP---NQGELISCDRDGNIRIW--DLGENQ 149 +W + H V +V P + + S D +RIW D Sbjct: 196 IWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPANPL 255 Query: 150 CTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTK 202 + D ++ +S + G++LAA+ +W+ + +K + + Sbjct: 256 QWNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVTLWKENLKGEWECVKTIEE 308 Score = 49.7 bits (117), Expect = 1e-06, Method: Composition-based stats. Identities = 13/54 (24%), Positives = 23/54 (42%), Gaps = 2/54 (3%) Query: 248 GHQRWVWDCAFSADSAYLVTASSDHYVRLWDLS--TREIVRQYGGHHKGAVCVA 299 GH + D L T SSD ++++++ T+ + GH CV+ Sbjct: 16 GHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVS 69 >6QDV-o nrPDB Length = 513 Score = 169 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 56/284 (19%), Positives = 106/284 (37%), Gaps = 16/284 (5%) Query: 4 ILVSAGYDHTIRFWEALT-GVCSRTIQHSDSQVNRLEITNDK-KLLATAGHQNVRLYDIR 61 +L+S D I+ WE C RT V + + L+ A + ++L+D Sbjct: 237 LLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTE 296 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDN---RWMVTSSEDGTIKVWDVRSPSIPRNY-KHNA 117 T ++ F + V F D V D I WD+RS I + Y +H Sbjct: 297 TGQ--CISRFTNRKVP-YCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLG 353 Query: 118 PVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAA 177 VN +V +S D ++R+W+ + S+ +++++ +G LA Sbjct: 354 AVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQ 413 Query: 178 NTKGNCYVWEMPNHTDASHLKPVTKFRAH--STYITRILLSSDVKHLATCSADHTARVWS 235 + ++ N L F+ H + Y ++ S D+ ++ + + +W Sbjct: 414 SMDNQILIFGAQNR---FRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWD 470 Query: 236 IDDDFKLETTLDGHQRWVWDCAFSADSAY-LVTASSDHYVRLWD 278 KL + H + + ++T D ++LWD Sbjct: 471 WKT-TKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 513 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 50/285 (17%), Positives = 109/285 (38%), Gaps = 18/285 (6%) Query: 23 VCSRTIQHSDSQVNRLEITN-DKKLLATAGHQ-NVRLYDIRTTNPNPVASFEGHRGNVTS 80 V+ + + LL + ++L+++ + +F GH V Sbjct: 213 KQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEV-YGERRCLRTFIGHSKAVRD 271 Query: 81 VSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPN---QGELISCDRD 137 + F ++++ D +K+WD + + + V +P+ Q ++ D Sbjct: 272 ICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSD 331 Query: 138 GNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHL 197 I WD+ + + ++ ++ + + + + VWE D Sbjct: 332 KKIVQWDIRSGEIVQEYDRHLG-AVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVD---F 387 Query: 198 KPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKL--ETTLDGHQRWVWD 255 K + + HS + LS + K LA S D+ ++ + F+L + GH + Sbjct: 388 KYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYA 445 Query: 256 CA--FSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCV 298 C FS D +Y+++ + + +WD T ++ ++ H K VC+ Sbjct: 446 CQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDK--VCI 488 Score = 88.2 bits (217), Expect = 4e-18, Method: Composition-based stats. Identities = 25/106 (23%), Positives = 48/106 (45%), Gaps = 2/106 (1%) Query: 198 KPVTKFRAHSTYITRILLSS-DVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDC 256 K + + H+ ++ + L L +CS D ++W + + + T GH + V D Sbjct: 213 KQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDI 272 Query: 257 AFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 F+ ++A+ D Y++LWD T + + ++ K CV N Sbjct: 273 CFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTN-RKVPYCVKFNP 317 >5YZG-W nrPDB Length = 579 Score = 169 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 56/284 (19%), Positives = 106/284 (37%), Gaps = 16/284 (5%) Query: 4 ILVSAGYDHTIRFWEALT-GVCSRTIQHSDSQVNRLEITNDK-KLLATAGHQNVRLYDIR 61 +L+S D I+ WE C RT V + + L+ A + ++L+D Sbjct: 303 LLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTE 362 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDN---RWMVTSSEDGTIKVWDVRSPSIPRNY-KHNA 117 T ++ F + V F D V D I WD+RS I + Y +H Sbjct: 363 TGQ--CISRFTNRKVP-YCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLG 419 Query: 118 PVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAA 177 VN +V +S D ++R+W+ + S+ +++++ +G LA Sbjct: 420 AVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQ 479 Query: 178 NTKGNCYVWEMPNHTDASHLKPVTKFRAH--STYITRILLSSDVKHLATCSADHTARVWS 235 + ++ N L F+ H + Y ++ S D+ ++ + + +W Sbjct: 480 SMDNQILIFGAQNR---FRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWD 536 Query: 236 IDDDFKLETTLDGHQRWVWDCAFSADSAY-LVTASSDHYVRLWD 278 KL + H + + ++T D ++LWD Sbjct: 537 WKT-TKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 579 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 50/285 (17%), Positives = 109/285 (38%), Gaps = 18/285 (6%) Query: 23 VCSRTIQHSDSQVNRLEITN-DKKLLATAGHQ-NVRLYDIRTTNPNPVASFEGHRGNVTS 80 V+ + + LL + ++L+++ + +F GH V Sbjct: 279 KQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEV-YGERRCLRTFIGHSKAVRD 337 Query: 81 VSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPN---QGELISCDRD 137 + F ++++ D +K+WD + + + V +P+ Q ++ D Sbjct: 338 ICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSD 397 Query: 138 GNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHL 197 I WD+ + + ++ ++ + + + + VWE D Sbjct: 398 KKIVQWDIRSGEIVQEYDRHLG-AVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVD---F 453 Query: 198 KPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKL--ETTLDGHQRWVWD 255 K + + HS + LS + K LA S D+ ++ + F+L + GH + Sbjct: 454 KYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYA 511 Query: 256 CA--FSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCV 298 C FS D +Y+++ + + +WD T ++ ++ H K VC+ Sbjct: 512 CQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDK--VCI 554 Score = 88.2 bits (217), Expect = 4e-18, Method: Composition-based stats. Identities = 25/106 (23%), Positives = 48/106 (45%), Gaps = 2/106 (1%) Query: 198 KPVTKFRAHSTYITRILLSS-DVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDC 256 K + + H+ ++ + L L +CS D ++W + + + T GH + V D Sbjct: 279 KQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDI 338 Query: 257 AFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 F+ ++A+ D Y++LWD T + + ++ K CV N Sbjct: 339 CFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTN-RKVPYCVKFNP 383 >6CHG-A nrPDB Length = 312 Score = 168 bits (426), Expect = 3e-42, Method: Composition-based stats. Identities = 44/277 (15%), Positives = 114/277 (41%), Gaps = 13/277 (4%) Query: 36 NRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSE 95 +I+ D +L+A + ++ +Y+I ++ + + H+ + + + D++ + + SE Sbjct: 17 TSCQISPDGELIAICQNTDMLVYEISSSKMMKLTT--THKECINCLCWSPDSKCIASGSE 74 Query: 96 DGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLT 155 D T+++ + I R H APV + + L S D +I+ W + ++ Sbjct: 75 DFTVEITHIIYGRIRRLMGHTAPVISICYNNKGNILCSSSMDESIKEWHVLSGTALKTMS 134 Query: 156 PEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHST--YITRI 213 D + D S+L++ + G +++ + L + A I+ + Sbjct: 135 AHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWIAEDGVVPISTV 194 Query: 214 LLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFS---------ADSAY 264 S + K L S D+ ++W + T L HQ ++ Sbjct: 195 KFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLKYNCGLELIYPQGKDPL 254 Query: 265 LVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 +++ + + +W++ ++ +V++ H+ + ++++ Sbjct: 255 VISGNDSGSMCVWNVYSKNLVQKIDEKHRNSPLISIS 291 Score = 97.4 bits (241), Expect = 6e-21, Method: Composition-based stats. Identities = 34/206 (16%), Positives = 88/206 (42%), Gaps = 22/206 (10%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITN-DKKLLATAG-HQNVRLYDI 60 IL S+ D +I+ W L+G +T+ V ++I D +L++ +R++D Sbjct: 108 NILCSSSMDESIKEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDT 167 Query: 61 RTTNPNPVASFEGH------RGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK 114 + + +++ +++V F ++ ++++ S D +K+W+ ++ R + Sbjct: 168 ESGHCLKTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFL 227 Query: 115 HNAPVNEVVIHPN-----------QGELISCDRDGNIRIWDLGENQCTHQL-TPEDDTSL 162 + + N +IS + G++ +W++ ++ ++ L Sbjct: 228 WPHQETKAKLKYNCGLELIYPQGKDPLVISGNDSGSMCVWNVYSKNLVQKIDEKHRNSPL 287 Query: 163 QSLSMASDGSMLAAANTKGNCYVWEM 188 S+S + D +A + G C ++ + Sbjct: 288 ISISASYDK--VATLSLNGECNLFRV 311 Score = 94.4 bits (233), Expect = 5e-20, Method: Composition-based stats. Identities = 38/255 (14%), Positives = 92/255 (36%), Gaps = 29/255 (11%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQ-NVRLYDI 60 S + S D T+ + G R + + V + N +L ++ +++ + + Sbjct: 66 SKCIASGSEDFTVEITHIIYGR-IRRLMGHTAPVISICYNNKGNILCSSSMDESIKEWHV 124 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQ-DNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNA-- 117 + + + H V S+ + D+ + + S DG I+++D S + ++ Sbjct: 125 LSG--TALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDW 182 Query: 118 -------PVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLT-PEDDT--------S 161 P++ V N L+ D +++W+ P +T Sbjct: 183 IAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLKYNCG 242 Query: 162 LQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKH 221 L+ + ++ + N G+ VW + + + + ++ + I S D Sbjct: 243 LELIYPQGKDPLVISGNDSGSMCVWNVYSKNLVQKIDEKHR----NSPLISISASYD--K 296 Query: 222 LATCSADHTARVWSI 236 +AT S + ++ + Sbjct: 297 VATLSLNGECNLFRV 311 Score = 74.3 bits (181), Expect = 5e-14, Method: Composition-based stats. Identities = 31/152 (20%), Positives = 55/152 (36%), Gaps = 11/152 (7%) Query: 152 HQLTPEDDTSLQSLSMASDGSMLAAA-NTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYI 210 Q+ P S ++ DG ++A NT Y + S K + H I Sbjct: 6 KQVLPASGKISTSCQISPDGELIAICQNTDMLVY--------EISSSKMMKLTTTHKECI 57 Query: 211 TRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASS 270 + S D K +A+ S D T + I + L GH V ++ L ++S Sbjct: 58 NCLCWSPDSKCIASGSEDFTVEITHII--YGRIRRLMGHTAPVISICYNNKGNILCSSSM 115 Query: 271 DHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 D ++ W + + ++ H V + + Sbjct: 116 DESIKEWHVLSGTALKTMSAHSDAVVSIDIPK 147 >6ID0-T nrPDB Length = 514 Score = 168 bits (425), Expect = 3e-42, Method: Composition-based stats. Identities = 55/283 (19%), Positives = 114/283 (40%), Gaps = 20/283 (7%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRTT 63 V+ D TI+ W+ +G ++ S V + ++ L + G + V+ +D+ Sbjct: 219 FVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYN 278 Query: 64 NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEV 122 + + GH V + +VT S D T ++WDVR+ + H V V Sbjct: 279 K--VIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATV 336 Query: 123 VIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGN 182 + ++I+ D IR+WDL + LT S++++ + A+ + N Sbjct: 337 RCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKK-SVRAVVLHPRHYTFASGSPD-N 394 Query: 183 CYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKL 242 W+ P+ + + H+ I + ++SD L + + + T +W + Sbjct: 395 IKQWKFPDGS------FIQNLSGHNAIINTLTVNSDG-VLVSGADNGTMHLWDWRTGYNF 447 Query: 243 ETTLDGH-------QRWVWDCAFSADSAYLVTASSDHYVRLWD 278 + + ++ CAF + L+TA +D ++++ Sbjct: 448 QRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVYR 490 Score = 161 bits (407), Expect = 3e-40, Method: Composition-based stats. Identities = 53/295 (17%), Positives = 106/295 (35%), Gaps = 23/295 (7%) Query: 17 WEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRTTNPNPVASFEGHR 75 W R I V + + + T + ++++D+ + S GH Sbjct: 190 WH-PPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKL--SLTGHI 246 Query: 76 GNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQGELISC 134 V V + ++ + ED +K WD+ + R+Y H + V + +HP L++C Sbjct: 247 STVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTC 306 Query: 135 DRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDA 194 RD RIWD+ H L+ + + ++ + + + +W++ Sbjct: 307 SRDSTARIWDVRTKASVHTLSGHTNA-VATVRCQAAEPQIITGSHDTTIRLWDLVAG--- 362 Query: 195 SHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVW 254 K H + ++L A+ S D+ + W D ++ L GH + Sbjct: 363 ---KTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQN-LSGHNAIIN 417 Query: 255 DCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGH--------HKGAVCVALN 301 ++D LV+ + + + LWD T ++ G A + Sbjct: 418 TLTVNSDG-VLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFD 471 Score = 150 bits (378), Expect = 9e-37, Method: Composition-based stats. Identities = 56/241 (23%), Positives = 94/241 (39%), Gaps = 9/241 (3%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDI 60 S L S G D ++ W+ R S V L++ +L T R++D+ Sbjct: 258 SPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDV 317 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPV 119 RT V + GH V +V Q ++T S D TI++WD+ + H V Sbjct: 318 RT--KASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSV 375 Query: 120 NEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANT 179 VV+HP S D I+ W + L+ + + +L++ SDG +L + Sbjct: 376 RAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGH-NAIINTLTVNSDG-VLVSGAD 432 Query: 180 KGNCYVWEMPNHTDASHLKPVTKFRAHSTY--ITRILLSSDVKHLATCSADHTARVWSID 237 G ++W+ + + + + + I L T AD T +V+ D Sbjct: 433 NGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVYRED 492 Query: 238 D 238 D Sbjct: 493 D 493 Score = 139 bits (349), Expect = 2e-33, Method: Composition-based stats. Identities = 44/189 (23%), Positives = 74/189 (39%), Gaps = 8/189 (4%) Query: 114 KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSM 173 H V + + P ++ D I+IWDL + LT T ++ + +++ Sbjct: 202 GHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHIST-VRGVIVSTRSPY 260 Query: 174 LAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARV 233 L + W++ + K + + H + + + L + L TCS D TAR+ Sbjct: 261 LFSCGEDKQVKCWDLE------YNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314 Query: 234 WSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHK 293 W + + TL GH V A ++T S D +RLWDL + H K Sbjct: 315 WDVRTKASV-HTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKK 373 Query: 294 GAVCVALND 302 V L+ Sbjct: 374 SVRAVVLHP 382 >3FM0-A nrPDB Length = 345 Score = 166 bits (420), Expect = 1e-41, Method: Composition-based stats. Identities = 66/307 (21%), Positives = 106/307 (34%), Gaps = 30/307 (9%) Query: 3 VILVSAGYDHTIRFW--EALTGVCSRTIQ-HSDSQVNRLEITNDKKLLATAG-HQNVRLY 58 +L S G D IR W E + +C + V ++ + LA+A ++ Sbjct: 29 TLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIW 88 Query: 59 DIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDV----RSPSIPRNYK 114 + V + EGH V SV++ + T S D ++ VW+V + Sbjct: 89 KKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNS 148 Query: 115 HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQ--CTHQLTPEDDTSLQSLSMASDGS 172 H V VV HP+Q L S D ++++ E+ C L + T + SL+ G Sbjct: 149 HTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHEST-VWSLAFDPSGQ 207 Query: 173 MLAAANTKGNCYVWE---------MPNHTDASHLKPVTKFRA-HSTYITRILLSSDVKHL 222 LA+ + +W + K + HS I I L Sbjct: 208 RLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGAL 267 Query: 223 ATCSADHTARVWSIDDDFKLE--------TTLDGHQRWVWDCAFSADSA-YLVTASSDHY 273 AT D RV+ D + + H + V A++ L + S D Sbjct: 268 ATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGE 327 Query: 274 VRLWDLS 280 V W Sbjct: 328 VAFWKYQ 334 Score = 160 bits (405), Expect = 7e-40, Method: Composition-based stats. Identities = 49/224 (21%), Positives = 95/224 (42%), Gaps = 18/224 (8%) Query: 81 VSFQQDNRWMVTSSEDGTIKVWDVRSPSI----PRNYKHNAPVNEVVIHPNQGELISCDR 136 +++ + + D I++W S + H V +V P L S Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81 Query: 137 DGNIRIWDLGEN--QCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDA 194 D IW ++ +C L ++ ++S++ A G++LA + + +VWE+ + Sbjct: 82 DATTCIWKKNQDDFECVTTLEGHEN-EVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDE- 139 Query: 195 SHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVW-SIDDDFKLETTLDGHQRWV 253 + V+ +H+ + ++ + LA+ S D T +++ +DD+ TL+GH+ V Sbjct: 140 --YECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTV 197 Query: 254 WDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVC 297 W AF L + S D VR+W + G+ +G C Sbjct: 198 WSLAFDPSGQRLASCSDDRTVRIWR-------QYLPGNEQGVAC 234 Score = 149 bits (376), Expect = 1e-36, Method: Composition-based stats. Identities = 62/309 (20%), Positives = 112/309 (36%), Gaps = 37/309 (11%) Query: 26 RTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRTTNPNPVASF-EGHRGNVTSVSF 83 R H DS+ L LLA+ G + +R++ + + EGH+ V V++ Sbjct: 10 RVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAW 69 Query: 84 QQDNRWMVTSSEDGTIKVWDVRS---PSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNI 140 ++ ++S D T +W + H V V P+ L +C RD ++ Sbjct: 70 SPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSV 129 Query: 141 RIWDLGEN---QCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHL 197 +W++ E +C L ++ + +LA+A+ ++ + Sbjct: 130 WVWEVDEEDEYECVSVLNSHTQ-DVKHVVWHPSQELLASASYDDTVKLY----REEEDDW 184 Query: 198 KPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVW--------------SIDDDFKLE 243 H + + + + LA+CS D T R+W D +K Sbjct: 185 VCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCI 244 Query: 244 TTLDG-HQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTRE---------IVRQYGGHHK 293 TL G H R ++D A+ + L TA D +R++ + H + Sbjct: 245 CTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQ 304 Query: 294 GAVCVALND 302 CVA N Sbjct: 305 DVNCVAWNP 313 Score = 74.3 bits (181), Expect = 7e-14, Method: Composition-based stats. Identities = 29/109 (26%), Positives = 44/109 (40%), Gaps = 5/109 (4%) Query: 196 HLKPVTKFRAHST-YITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTL--DGHQRW 252 L + + AH + + LA+C D R+W + D + ++ +GHQR Sbjct: 4 SLVLLGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRT 63 Query: 253 VWDCAFSADSAYLVTASSDHYVRLWDLSTR--EIVRQYGGHHKGAVCVA 299 V A+S YL +AS D +W + E V GH VA Sbjct: 64 VRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVA 112 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 13/70 (18%), Positives = 22/70 (31%), Gaps = 4/70 (5%) Query: 237 DDDFKLETTLDGHQRW-VWDCAFSADSAYLVTASSDHYVRLWDLS--TREIVRQY-GGHH 292 D L + H W A++ L + D +R+W + GH Sbjct: 2 KDSLVLLGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQ 61 Query: 293 KGAVCVALND 302 + VA + Sbjct: 62 RTVRKVAWSP 71 >6Q8F-A nrPDB Length = 514 Score = 166 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 60/291 (20%), Positives = 117/291 (40%), Gaps = 24/291 (8%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHS--------DSQVNRLEITNDKKLLATAG-HQN 54 LV+ D I W TG + +++ D V + + D ++LAT Sbjct: 229 YLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGK 288 Query: 55 VRLYDIRTTNPNPVASFE-GHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY 113 ++++ I++ + FE H VT +SF +D+ ++++S D TI++ ++S + + Sbjct: 289 IKVWKIQSGQ--CLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEF 346 Query: 114 -KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQL-----TPEDDTSLQSLSM 167 H++ VNE + +IS DG ++IW++ +C++ T D ++ S+ + Sbjct: 347 RGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVIL 406 Query: 168 ASDGS-MLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCS 226 N + M ++ + + LS + + Sbjct: 407 LPKNPEHFVVCNRSNTVVIMNMQGQI----VRSFSSGKREGGDFVCCALSPRGEWIYCVG 462 Query: 227 ADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 D +S KLE TL H++ V A + T S D ++LW Sbjct: 463 EDFVLYCFSTVTG-KLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 512 Score = 158 bits (400), Expect = 2e-39, Method: Composition-based stats. Identities = 46/284 (16%), Positives = 102/284 (35%), Gaps = 12/284 (4%) Query: 30 HSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRTTNPNPVASFEGHRGN------VTSVS 82 S V + D + L T + +++ T ++ V + Sbjct: 213 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMC 272 Query: 83 FQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK--HNAPVNEVVIHPNQGELISCDRDGNI 140 F +D + T ++DG IKVW ++S R ++ H+ V + + +++S D I Sbjct: 273 FSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTI 332 Query: 141 RIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPV 200 RI L + + + + DG + +A++ G +W M ++ K + Sbjct: 333 RIHGLKSGKTLKEFRGHSSF-VNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSL 391 Query: 201 TKFRAHSTYITRILL-SSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRW-VWDCAF 258 + ++L + +H C+ +T + ++ + + CA Sbjct: 392 GSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCAL 451 Query: 259 SADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 S ++ D + + T ++ R H K + +A + Sbjct: 452 SPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHP 495 Score = 140 bits (352), Expect = 8e-34, Method: Composition-based stats. Identities = 42/185 (22%), Positives = 76/185 (41%), Gaps = 13/185 (7%) Query: 112 NYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPED-------DTSLQS 164 + + V P+ L++ DG I +W+ + L + D ++ Sbjct: 211 KFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLC 270 Query: 165 LSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLAT 224 + + D MLA G VW++ + + RAHS +T + S D + + Sbjct: 271 MCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFE-----RAHSKGVTCLSFSKDSSQILS 325 Query: 225 CSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREI 284 S D T R+ + K GH +V + F+ D Y+++ASSD V++W++ T E Sbjct: 326 ASFDQTIRIHGLKSG-KTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTEC 384 Query: 285 VRQYG 289 + Sbjct: 385 SNTFK 389 Score = 107 bits (267), Expect = 6e-24, Method: Composition-based stats. Identities = 33/150 (22%), Positives = 59/150 (39%), Gaps = 2/150 (1%) Query: 149 QCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLK--PVTKFRAH 206 Q + + + ++ + DG L + G VW LK F Sbjct: 205 QLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMM 264 Query: 207 STYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLV 266 + + S D + LAT + D +VW I L H + V +FS DS+ ++ Sbjct: 265 DDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQIL 324 Query: 267 TASSDHYVRLWDLSTREIVRQYGGHHKGAV 296 +AS D +R+ L + + ++++ GH Sbjct: 325 SASFDQTIRIHGLKSGKTLKEFRGHSSFVN 354 Score = 93.6 bits (231), Expect = 9e-20, Method: Composition-based stats. Identities = 33/196 (16%), Positives = 72/196 (36%), Gaps = 12/196 (6%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATA-GHQNVRLYDI 60 S ++SA +D TIR +G + + S VN T D + +A V+++++ Sbjct: 320 SSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNM 379 Query: 61 RTTNPNPVASFEGHRGN----VTSVSFQQDNR-WMVTSSEDGTIKVWDVRSPSIPRNY-- 113 +TT + G V SV N V + T+ + +++ I R++ Sbjct: 380 KTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQ-GQIVRSFSS 438 Query: 114 --KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDG 171 + + P + D + + + LT + + ++ Sbjct: 439 GKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVI-GIAHHPHQ 497 Query: 172 SMLAAANTKGNCYVWE 187 +++A + G +W+ Sbjct: 498 NLIATYSEDGLLKLWK 513 >5WLC-LO nrPDB Length = 923 Score = 164 bits (416), Expect = 4e-41, Method: Composition-based stats. Identities = 53/286 (18%), Positives = 113/286 (39%), Gaps = 9/286 (3%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIR 61 + +L R ++ + + + VN + + + LA + +L Sbjct: 272 TRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYE 331 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVN 120 + + + +GH + S+++ D +VT+SEDG IKVWD+ S + +H + V Sbjct: 332 WQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVT 391 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 V + S DG +R WDL + T + L++ G ++ A + Sbjct: 392 AVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLD 451 Query: 181 G-NCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDD 239 + +VW + + + H ++ + S + LA+ S D T R+WSI Sbjct: 452 NFDIHVWSV------QTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGR 505 Query: 240 FKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIV 285 + ++ + V + D + ++ + ++++ + V Sbjct: 506 SQQVEPIEVYSD-VLALSMRPDGKEVAVSTLKGQISIFNIEDAKQV 550 Score = 162 bits (411), Expect = 1e-40, Method: Composition-based stats. Identities = 73/339 (21%), Positives = 120/339 (35%), Gaps = 52/339 (15%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQ---------HSDSQVNRLEITNDKK-LLATAGHQN 54 L S ++ W+ R + L + D + +L T+ + Sbjct: 113 LASG---RFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLS 169 Query: 55 VRLYDIRTTNPNPVAS-FEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW----------- 102 +++ + + N A+ F GHR V F D + T S+DG + VW Sbjct: 170 AKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDD 229 Query: 103 ------------DVRSPSIPRNYKH-----NAPVNEVVIHPNQGELISCDRDGNIRIWDL 145 D+ S KH A V V HP L G R++DL Sbjct: 230 NESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDL 289 Query: 146 GENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK-GNCYVWEMPNHTDASHLKPVTKFR 204 + QL+ + ++S+ G LA ++K G V+E + + + K + Sbjct: 290 PDFTLIQQLSM-GQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESY------ILKQQ 342 Query: 205 AHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAY 264 H + S D + T S D +VW I F T + H V F+ Sbjct: 343 GHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGF-CLATFEEHTSSVTAVQFAKRGQV 401 Query: 265 LVTASSDHYVRLWDLSTREIVRQYGGHHKGAV-CVALND 302 + ++S D VR WDL R + G + C+A++ Sbjct: 402 MFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDP 440 Score = 137 bits (346), Expect = 4e-33, Method: Composition-based stats. Identities = 50/208 (24%), Positives = 96/208 (46%), Gaps = 10/208 (4%) Query: 81 VSFQQDNRWMVTSSEDGTIKVWD-VRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGN 139 ++F D + +++ + V+D + + S Y+H + + ++ LIS D DG Sbjct: 20 ITFSDDGKQLLS-PVGNRVSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDGR 78 Query: 140 IRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKP 199 + + H ++ S ++ + DG + A A+ + +W+ P+ P Sbjct: 79 AILVNFKARNVLHHFNFKEKCS--AVKFSPDGRLFALASGRF-LQIWKTPDVNKDRQFAP 135 Query: 200 VTKFRAHSTY---ITRILLSSDVKHLATCSADHTARVWSIDDDFKLE--TTLDGHQRWVW 254 + R H+ + IT + S D + + T S D +A++WS+D + K TT +GH+ +V Sbjct: 136 FVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVM 195 Query: 255 DCAFSADSAYLVTASSDHYVRLWDLSTR 282 FS D + T S D V +W+ + R Sbjct: 196 GAFFSHDQEKIYTVSKDGAVFVWEFTKR 223 Score = 105 bits (262), Expect = 3e-23, Method: Composition-based stats. Identities = 45/298 (15%), Positives = 104/298 (34%), Gaps = 40/298 (13%) Query: 38 LEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDG 97 + ++D K L + V ++D+ N + +E HR N+ ++ + +++ EDG Sbjct: 20 ITFSDDGKQLLSPVGNRVSVFDL-INNKSFTFEYE-HRKNIAAIDLNKQGTLLISIDEDG 77 Query: 98 TIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIW---DLGENQ----- 149 + + ++ ++ ++ + V P+ ++IW D+ +++ Sbjct: 78 RAILVNFKARNVLHHFNFKEKCSAVKFSPDGRLFALASG-RFLQIWKTPDVNKDRQFAPF 136 Query: 150 CTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTY 209 H++ + SL+ + D + + + +W + + T F H Y Sbjct: 137 VRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEK---NLAATTFNGHRDY 193 Query: 210 ITRILLSSDVKHLATCSADHTARVWSIDD------------------------DFKL--E 243 + S D + + T S D VW +++ + Sbjct: 194 VMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKK 253 Query: 244 TTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 +Q V F + L + RL+DL +++Q V++N Sbjct: 254 HFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVN 311 >3MKQ-A nrPDB Length = 814 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 49/282 (17%), Positives = 107/282 (37%), Gaps = 13/282 (4%) Query: 26 RTIQHSDSQVNRLEITNDKKL-LATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQ 84 +T + +V ++ + L T V +++ T V S + V + F Sbjct: 7 KTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYET--QVEVRSIQVTETPVRAGKFI 64 Query: 85 QDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDGNIRIW 143 W++ S+D I+V++ + +++ H + + +HP + ++S D +++W Sbjct: 65 ARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLW 124 Query: 144 DLGENQCTHQLTPEDDTSLQSLSMAS-DGSMLAAANTKGNCYVWEMPNHTDASHLKPVTK 202 + N Q + + ++ D S A+ VW + T L Sbjct: 125 NWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLT---- 180 Query: 203 FRAHSTYITRILLSS--DVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSA 260 + + D ++ T S D T ++W TL+GH V F Sbjct: 181 -TGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKS-CVATLEGHMSNVSFAVFHP 238 Query: 261 DSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 +++ S D +++W+ ST ++ + + + C+A + Sbjct: 239 TLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHP 280 Score = 160 bits (404), Expect = 7e-40, Method: Composition-based stats. Identities = 48/278 (17%), Positives = 108/278 (38%), Gaps = 17/278 (6%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQ-NVRLYDIR 61 +++ Y + W T V R+IQ +++ V + K + +R+++ Sbjct: 26 PWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKFIARKNWIIVGSDDFRIRVFNYN 85 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSP-SIPRNY-KHNAPV 119 T V FE H + S++ ++++ S+D T+K+W+ + ++ + + H V Sbjct: 86 TGEK--VVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALEQTFEGHEHFV 143 Query: 120 NEVVIHPNQG-ELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMA--SDGSMLAA 176 V +P S D +++W LG++ LT + + + D + Sbjct: 144 MCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMIT 203 Query: 177 ANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI 236 A+ +W+ + V H + ++ + + + + S D T ++W+ Sbjct: 204 ASDDLTIKIWDYQTKS------CVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNS 257 Query: 237 DDDFKLETTLDGHQRWVWDCAFSADSA--YLVTASSDH 272 +K+E TL+ W A Y+ + + Sbjct: 258 ST-YKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNG 294 Score = 119 bits (299), Expect = 1e-27, Method: Composition-based stats. Identities = 40/242 (16%), Positives = 84/242 (34%), Gaps = 54/242 (22%) Query: 108 SIPRNYKHNAP-VNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLS 166 I + + + + V + HP + +++ G + IW+ + +T +++ Sbjct: 4 DIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSI-QVTETPVRAGK 62 Query: 167 MASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCS 226 + + + + V+ + V F AH YI I + ++ + S Sbjct: 63 FIARKNWIIVGSDDFRIRVFNYN------TGEKVVDFEAHPDYIRSIAVHPTKPYVLSGS 116 Query: 227 ADHTARVWSIDDDFKLETTLDGHQRWVWDCAFS--------------------------- 259 D T ++W+ ++++ LE T +GH+ +V AF+ Sbjct: 117 DDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPN 176 Query: 260 -------------------ADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVAL 300 D Y++TAS D +++WD T+ V GH Sbjct: 177 FTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVF 236 Query: 301 ND 302 + Sbjct: 237 HP 238 Score = 78.2 bits (191), Expect = 4e-15, Method: Composition-based stats. Identities = 44/305 (14%), Positives = 95/305 (31%), Gaps = 39/305 (12%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIR 61 +++A D TI+ W+ T C T++ S V+ ++ + +++++ Sbjct: 199 PYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSS 258 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSS-EDGTIKVWDVRSPSIPRNYKHNAPVN 120 T + ++ R +S D V + + + PV Sbjct: 259 TYKVE--KTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSL---DPVG 313 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSL----QSLSMASDGSMLAA 176 ++V + S IR + E L ++ S+ QSL+ + +G + Sbjct: 314 KLVWSGGKNAAASDIFTAVIRGNEEVEQDEPLSLQTKELGSVDVFPQSLAHSPNGRFVTV 373 Query: 177 ANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI 236 G ++ + + K D A + + Sbjct: 374 VG-DGEYVIYTALAWRNKAFGKCQDFVWG-----------PDSNSYALIDETGQIKYY-- 419 Query: 237 DDDFKLETTLDGHQRWVWDCAFSADSAYLVTAS-----SDHYVRLWDLSTREIVRQYGGH 291 +FK T+ W + L + + SD +V +D +VR+ + Sbjct: 420 -KNFKEVTS--------WSVPMHSAIDRLFSGALLGVKSDGFVYFFDWDNGTLVRRIDVN 470 Query: 292 HKGAV 296 K + Sbjct: 471 AKDVI 475 Score = 73.2 bits (178), Expect = 1e-13, Method: Composition-based stats. Identities = 24/149 (16%), Positives = 43/149 (28%), Gaps = 44/149 (29%) Query: 197 LKPVTKFRAHSTYITRILLSSDVKHLAT-------------------------------- 224 L F S + I + T Sbjct: 3 LDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGK 62 Query: 225 ----------CSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYV 274 S D RV++ + K+ + H ++ A Y+++ S D V Sbjct: 63 FIARKNWIIVGSDDFRIRVFNYNTGEKVVD-FEAHPDYIRSIAVHPTKPYVLSGSDDLTV 121 Query: 275 RLWDL-STREIVRQYGGHHKGAVCVALND 302 +LW+ + + + + GH +CVA N Sbjct: 122 KLWNWENNWALEQTFEGHEHFVMCVAFNP 150 Score = 32.3 bits (72), Expect = 0.29, Method: Composition-based stats. Identities = 9/48 (18%), Positives = 17/48 (35%) Query: 239 DFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVR 286 ++ T V F +++T V +W+ T+ VR Sbjct: 2 KLDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVR 49 >5L9T-R nrPDB Length = 493 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 48/243 (19%), Positives = 98/243 (40%), Gaps = 11/243 (4%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRT 62 ++ + ++ W+A G ++ ++V L + +L + + + + DIRT Sbjct: 242 NLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAE-QLSSGSRDRMILQRDIRT 300 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNE 121 +GHR V + + D++ + + D + VW+ S S + Y +H A V Sbjct: 301 PPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKA 360 Query: 122 VVIHPNQGELISCD---RDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAAN 178 + P+Q L++ D IR W+ Q + + S ++ + Sbjct: 361 IAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGY 420 Query: 179 TKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDD 238 ++ VW+ P+ T V K HS + + +S D + + T + D T R W++ Sbjct: 421 SQNQILVWKYPSLT------QVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFS 474 Query: 239 DFK 241 + Sbjct: 475 KTR 477 Score = 119 bits (299), Expect = 1e-27, Method: Composition-based stats. Identities = 50/290 (17%), Positives = 103/290 (35%), Gaps = 24/290 (8%) Query: 5 LVSAGYDHTIRFWEALTGVCSR--TIQHSDSQVNRLEITNDKKLLATAGHQN-VRLYDIR 61 ++S G + W A T +R + V + + L+A H+ V+++D Sbjct: 200 VLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAA 259 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRS---PSIPRNYKHNAP 118 ++ EGH V ++++ + + + S D I D+R+ S R H Sbjct: 260 AGKK--LSMLEGHTARVGALAW--NAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQE 315 Query: 119 VNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGS-MLAAA 177 V + + L S D + +W+ Q T ++++++ + +LA+ Sbjct: 316 VCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHL-AAVKAIAWSPHQHGLLASG 374 Query: 178 N--TKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLAT--CSADHTARV 233 W + + + + S L + + + V Sbjct: 375 GGTADRCIRFWNTLTGQPLQCIDT-------GSQVCNLAWSKHANELVSTHGYSQNQILV 427 Query: 234 WSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTRE 283 W ++ L GH V A S D +VT + D +R W++ ++ Sbjct: 428 WKYPSLTQV-AKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKT 476 Score = 118 bits (295), Expect = 3e-27, Method: Composition-based stats. Identities = 56/277 (20%), Positives = 103/277 (37%), Gaps = 20/277 (7%) Query: 34 QVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTS 93 +N ++ ++ +L+ V L+ T+ + +VTSV + + + Sbjct: 189 YLNLVDWSS-LNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVG 247 Query: 94 SEDGTIKVWDVRSPS-IPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGEN--QC 150 + G +++WD + + H A V + N +L S RD I D+ Q Sbjct: 248 THKGFVQIWDAAAGKKLSMLEGHTARVGALAW--NAEQLSSGSRDRMILQRDIRTPPLQS 305 Query: 151 THQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYI 210 +L + L ++D +LA+ VW S L PV ++ H + Sbjct: 306 ERRLQGHRQ-EVCGLKWSTDHQLLASGGNDNKLLVWN------HSSLSPVQQYTEHLAAV 358 Query: 211 TRILLSSDVKHLATCS---ADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVT 267 I S L AD R W+ L+ G Q V + A+S + LV+ Sbjct: 359 KAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQ--VCNLAWSKHANELVS 416 Query: 268 --ASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 S + + +W + V + GH + +A++ Sbjct: 417 THGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSP 453 >5I2T-A nrPDB Length = 742 Score = 162 bits (410), Expect = 2e-40, Method: Composition-based stats. Identities = 53/286 (18%), Positives = 113/286 (39%), Gaps = 9/286 (3%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIR 61 + +L R ++ + + + VN + + + LA + +L Sbjct: 297 TRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYE 356 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVN 120 + + + +GH + S+++ D +VT+SEDG IKVWD+ S + +H + V Sbjct: 357 WQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEHTSSVT 416 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 V + S DG +R WDL + T + L++ G ++ A + Sbjct: 417 AVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLD 476 Query: 181 G-NCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDD 239 + +VW + + + H ++ + S + LA+ S D T R+WSI Sbjct: 477 NFDIHVWSV------QTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGR 530 Query: 240 FKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIV 285 + ++ + V + D + ++ + ++++ + V Sbjct: 531 SQQVEPIEVYSD-VLALSMRPDGKEVAVSTLKGQISIFNIEDAKQV 575 Score = 159 bits (403), Expect = 1e-39, Method: Composition-based stats. Identities = 73/339 (21%), Positives = 120/339 (35%), Gaps = 52/339 (15%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQ---------HSDSQVNRLEITNDKK-LLATAGHQN 54 L S ++ W+ R + L + D + +L T+ + Sbjct: 138 LASG---RFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLS 194 Query: 55 VRLYDIRTTNPNPVAS-FEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW----------- 102 +++ + + N A+ F GHR V F D + T S+DG + VW Sbjct: 195 AKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDD 254 Query: 103 ------------DVRSPSIPRNYKH-----NAPVNEVVIHPNQGELISCDRDGNIRIWDL 145 D+ S KH A V V HP L G R++DL Sbjct: 255 NESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDL 314 Query: 146 GENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK-GNCYVWEMPNHTDASHLKPVTKFR 204 + QL+ + ++S+ G LA ++K G V+E + + + K + Sbjct: 315 PDFTLIQQLSM-GQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESY------ILKQQ 367 Query: 205 AHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAY 264 H + S D + T S D +VW I F T + H V F+ Sbjct: 368 GHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGF-CLATFEEHTSSVTAVQFAKRGQV 426 Query: 265 LVTASSDHYVRLWDLSTREIVRQYGGHHKGAV-CVALND 302 + ++S D VR WDL R + G + C+A++ Sbjct: 427 MFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDP 465 Score = 135 bits (341), Expect = 2e-32, Method: Composition-based stats. Identities = 50/208 (24%), Positives = 96/208 (46%), Gaps = 10/208 (4%) Query: 81 VSFQQDNRWMVTSSEDGTIKVWD-VRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGN 139 ++F D + +++ + V+D + + S Y+H + + ++ LIS D DG Sbjct: 45 ITFSDDGKQLLS-PVGNRVSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDGR 103 Query: 140 IRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKP 199 + + H ++ S ++ + DG + A A+ + +W+ P+ P Sbjct: 104 AILVNFKARNVLHHFNFKEKCS--AVKFSPDGRLFALASGRF-LQIWKTPDVNKDRQFAP 160 Query: 200 VTKFRAHSTY---ITRILLSSDVKHLATCSADHTARVWSIDDDFKLE--TTLDGHQRWVW 254 + R H+ + IT + S D + + T S D +A++WS+D + K TT +GH+ +V Sbjct: 161 FVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVM 220 Query: 255 DCAFSADSAYLVTASSDHYVRLWDLSTR 282 FS D + T S D V +W+ + R Sbjct: 221 GAFFSHDQEKIYTVSKDGAVFVWEFTKR 248 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 45/298 (15%), Positives = 104/298 (34%), Gaps = 40/298 (13%) Query: 38 LEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDG 97 + ++D K L + V ++D+ N + +E HR N+ ++ + +++ EDG Sbjct: 45 ITFSDDGKQLLSPVGNRVSVFDL-INNKSFTFEYE-HRKNIAAIDLNKQGTLLISIDEDG 102 Query: 98 TIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIW---DLGENQ----- 149 + + ++ ++ ++ + V P+ ++IW D+ +++ Sbjct: 103 RAILVNFKARNVLHHFNFKEKCSAVKFSPDGRLFALASG-RFLQIWKTPDVNKDRQFAPF 161 Query: 150 CTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTY 209 H++ + SL+ + D + + + +W + + T F H Y Sbjct: 162 VRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNL---AATTFNGHRDY 218 Query: 210 ITRILLSSDVKHLATCSADHTARVWSIDD------------------------DFKL--E 243 + S D + + T S D VW +++ + Sbjct: 219 VMGAFFSHDQEKIYTVSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKK 278 Query: 244 TTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 +Q V F + L + RL+DL +++Q V++N Sbjct: 279 HFFYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVN 336 >5K1B-B nrPDB Length = 677 Score = 160 bits (404), Expect = 8e-40, Method: Composition-based stats. Identities = 53/235 (22%), Positives = 99/235 (42%), Gaps = 9/235 (3%) Query: 75 RGNVTSVSFQQDNRWMVTSSEDGTIKVWDV----RSPSIPRNYKHNAPVNEVVIHPNQGE 130 R V ++ + T+ D I++W V + P I H VN++V+ N Sbjct: 30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKT 89 Query: 131 LISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWE--- 187 LIS D +++W+ + C L D +++L+ A D ++A+A ++W+ Sbjct: 90 LISASSDTTVKVWNAHKGFCMSTLRTHKDY-VKALAYAKDKELVASAGLDRQIFLWDVNT 148 Query: 188 MPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLD 247 + T +++ + + I + ++ + + S + RVW KL L Sbjct: 149 LTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMK-LK 207 Query: 248 GHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 GH V + D ++ SSD +RLW L + + Y H +G + +ND Sbjct: 208 GHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVND 262 Score = 151 bits (381), Expect = 4e-37, Method: Composition-based stats. Identities = 56/261 (21%), Positives = 108/261 (41%), Gaps = 18/261 (6%) Query: 35 VNRLEITNDKKLLATAGHQNV-RLYDIRTTNPNP-VASFEGHRGNVTSVSFQQDNRWMVT 92 VN L++ L TAG ++ R++ + +P +AS E H V + + + +++ Sbjct: 33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLIS 92 Query: 93 SSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGE---- 147 +S D T+KVW+ + H V + ++ + S D I +WD+ Sbjct: 93 ASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTAL 152 Query: 148 ----NQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKF 203 N T + S+ SL+M G+++ + +T+ VW+ + K Sbjct: 153 TASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWD------PRTCAKLMKL 206 Query: 204 RAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSA 263 + H+ + +LL+ D + S+D T R+WS+ + T H VW + Sbjct: 207 KGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQ-RCIATYRVHDEGVWALQVNDAFT 265 Query: 264 YLVTASSDHYVRLWDLSTREI 284 ++ + D + DL +I Sbjct: 266 HVYSGGRDRKIYCTDLRNPDI 286 Score = 146 bits (369), Expect = 1e-35, Method: Composition-based stats. Identities = 62/304 (20%), Positives = 121/304 (39%), Gaps = 33/304 (10%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRT- 62 L+SA D T++ W A G C T++ V L DK+L+A+AG + + L+D+ T Sbjct: 90 LISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTL 149 Query: 63 ------TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSP-SIPRNYKH 115 N +S G++ ++ S++ Q +V+ S + ++VWD R+ + + H Sbjct: 150 TALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGH 209 Query: 116 NAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLA 175 V ++++ + + +S DG IR+W LG+ +C D+ + +L + + + Sbjct: 210 TDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDE-GVWALQVNDAFTHVY 268 Query: 176 AANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWS 235 + Y ++ N D L K + R +AT T W+ Sbjct: 269 SGGRDRKIYCTDLRNP-DIRVLICEEKAPVLKMELDRSADPPPAIWVAT--TKSTVNKWT 325 Query: 236 IDDDFKLETTLDGHQR--------------------WVWDCAFSADSAYLVTASSDHYVR 275 + + D + C D +++T +++ V Sbjct: 326 LKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGGASIIQCHILNDKRHILTKDTNNNVA 385 Query: 276 LWDL 279 WD+ Sbjct: 386 YWDV 389 Score = 103 bits (257), Expect = 9e-23, Method: Composition-based stats. Identities = 49/270 (18%), Positives = 97/270 (35%), Gaps = 34/270 (12%) Query: 4 ILVSAGYDHTIRFWEALTGVCS---------RTIQHSDSQVNRLEITNDKKLLATAGHQN 54 ++ SAG D I W+ T ++ + + L + ++ + + Sbjct: 131 LVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEK 190 Query: 55 V-RLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY 113 V R++D RT + +GH NV ++ +D ++ S DGTI++W + Y Sbjct: 191 VLRVWDPRT--CAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATY 248 Query: 114 K-HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDG- 171 + H+ V + ++ + S RD I DL L E+ + + + Sbjct: 249 RVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPD-IRVLICEEKAPVLKMELDRSAD 307 Query: 172 --SMLAAANTKGNCYVW----------------EMPNHTDASHLKPVTKFRAHSTYITRI 213 + A TK W + N +P + ++ I Sbjct: 308 PPPAIWVATTKSTVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGGASIIQCH 367 Query: 214 LLSSDVKHLATCSADHTARVWSIDDDFKLE 243 +L+ D +H+ T ++ W + K+E Sbjct: 368 ILN-DKRHILTKDTNNNVAYWDVLKACKVE 396 >2YNP-A nrPDB Length = 604 Score = 158 bits (400), Expect = 2e-39, Method: Composition-based stats. Identities = 50/282 (17%), Positives = 107/282 (37%), Gaps = 13/282 (4%) Query: 26 RTIQHSDSQVNRLEITNDKKL-LATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQ 84 +T + +V ++ + L T V L++ T V S + V + F Sbjct: 7 KTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYET--QVEVRSIQVTETPVRAGKFI 64 Query: 85 QDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDGNIRIW 143 W++ S+D I+V++ + +++ H + + +HP + ++S D +++W Sbjct: 65 ARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLW 124 Query: 144 DLGENQCTHQLTPEDDTSLQSLSMAS-DGSMLAAANTKGNCYVWEMPNHTDASHLKPVTK 202 + N Q + + ++ D S A+ VW + T L Sbjct: 125 NWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLT---- 180 Query: 203 FRAHSTYITRILLSS--DVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSA 260 + + D ++ T S D T ++W TL+GH V F Sbjct: 181 -TGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKS-CVATLEGHMSNVSFAVFHP 238 Query: 261 DSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 +++ S D +++W+ ST ++ + + + C+A + Sbjct: 239 TLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHP 280 Score = 155 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 48/278 (17%), Positives = 108/278 (38%), Gaps = 17/278 (6%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQ-NVRLYDIR 61 +++ Y + W T V R+IQ +++ V + K + +R+++ Sbjct: 26 PWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIARKNWIIVGSDDFRIRVFNYN 85 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSP-SIPRNY-KHNAPV 119 T V FE H + S++ ++++ S+D T+K+W+ + ++ + + H V Sbjct: 86 TGEK--VVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALEQTFEGHEHFV 143 Query: 120 NEVVIHPNQG-ELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMA--SDGSMLAA 176 V +P S D +++W LG++ LT + + + D + Sbjct: 144 MCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMIT 203 Query: 177 ANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI 236 A+ +W+ + V H + ++ + + + + S D T ++W+ Sbjct: 204 ASDDLTIKIWDYQTKS------CVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNS 257 Query: 237 DDDFKLETTLDGHQRWVWDCAFSADSA--YLVTASSDH 272 +K+E TL+ W A Y+ + + Sbjct: 258 ST-YKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNG 294 Score = 116 bits (290), Expect = 1e-26, Method: Composition-based stats. Identities = 39/242 (16%), Positives = 84/242 (34%), Gaps = 54/242 (22%) Query: 108 SIPRNYKHNAP-VNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLS 166 I + + + + V + HP + +++ G + +W+ + +T +++ Sbjct: 4 DIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSI-QVTETPVRAGK 62 Query: 167 MASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCS 226 + + + + V+ + V F AH YI I + ++ + S Sbjct: 63 FIARKNWIIVGSDDFRIRVFNYN------TGEKVVDFEAHPDYIRSIAVHPTKPYVLSGS 116 Query: 227 ADHTARVWSIDDDFKLETTLDGHQRWVWDCAFS--------------------------- 259 D T ++W+ ++++ LE T +GH+ +V AF+ Sbjct: 117 DDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPN 176 Query: 260 -------------------ADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVAL 300 D Y++TAS D +++WD T+ V GH Sbjct: 177 FTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVF 236 Query: 301 ND 302 + Sbjct: 237 HP 238 Score = 75.5 bits (184), Expect = 3e-14, Method: Composition-based stats. Identities = 44/305 (14%), Positives = 95/305 (31%), Gaps = 39/305 (12%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIR 61 +++A D TI+ W+ T C T++ S V+ ++ + +++++ Sbjct: 199 PYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSS 258 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSS-EDGTIKVWDVRSPSIPRNYKHNAPVN 120 T + ++ R +S D V + + + PV Sbjct: 259 TYKVE--KTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSL---DPVG 313 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSL----QSLSMASDGSMLAA 176 ++V + S IR + E L ++ S+ QSL+ + +G + Sbjct: 314 KLVWSGGKNAAASDIFTAVIRGNEEVEQDEPLSLQTKELGSVDVFPQSLAHSPNGRFVTV 373 Query: 177 ANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI 236 G ++ + + K D A + + Sbjct: 374 VG-DGEYVIYTALAWRNKAFGKCQDFVWG-----------PDSNSYALIDETGQIKYY-- 419 Query: 237 DDDFKLETTLDGHQRWVWDCAFSADSAYLVTAS-----SDHYVRLWDLSTREIVRQYGGH 291 +FK T+ W + L + + SD +V +D +VR+ + Sbjct: 420 -KNFKEVTS--------WSVPMHSAIDRLFSGALLGVKSDGFVYFFDWDNGTLVRRIDVN 470 Query: 292 HKGAV 296 K + Sbjct: 471 AKDVI 475 Score = 70.9 bits (172), Expect = 6e-13, Method: Composition-based stats. Identities = 24/149 (16%), Positives = 43/149 (28%), Gaps = 44/149 (29%) Query: 197 LKPVTKFRAHSTYITRILLSSDVKHLAT-------------------------------- 224 L F S + I + T Sbjct: 3 LDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGK 62 Query: 225 ----------CSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYV 274 S D RV++ + K+ + H ++ A Y+++ S D V Sbjct: 63 FIARKNWIIVGSDDFRIRVFNYNTGEKVVD-FEAHPDYIRSIAVHPTKPYVLSGSDDLTV 121 Query: 275 RLWDL-STREIVRQYGGHHKGAVCVALND 302 +LW+ + + + + GH +CVA N Sbjct: 122 KLWNWENNWALEQTFEGHEHFVMCVAFNP 150 Score = 32.7 bits (73), Expect = 0.20, Method: Composition-based stats. Identities = 12/106 (11%), Positives = 26/106 (24%), Gaps = 42/106 (39%) Query: 239 DFKLETTLDGHQRWVWDCAFSADSAYLVT------------------------------- 267 ++ T V F +++T Sbjct: 2 KLDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAG 61 Query: 268 -----------ASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 S D +R+++ +T E V + H +A++ Sbjct: 62 KFIARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHP 107 >3JB9-g nrPDB Length = 558 Score = 157 bits (397), Expect = 5e-39, Method: Composition-based stats. Identities = 53/285 (18%), Positives = 109/285 (38%), Gaps = 16/285 (5%) Query: 27 TIQHSDSQVNRLEITN-DKKLLATAGHQN-VRLYDIRTTNPNPVASFEGHRGNVTSVSFQ 84 T + ++ L LL + N ++++++ + + + +F+GH + +SF Sbjct: 261 TWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEV-YHDRSLLRTFQGHARPIRDLSFS 319 Query: 85 QDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIH--PNQ-GELISCDRDGNIR 141 QD R +++S D TIK+WD + + N V P++ E ++ D I Sbjct: 320 QDGRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGTADKRIL 379 Query: 142 IWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVT 201 +D+ + S++ +G + + WE +K V Sbjct: 380 QFDIRSPDIVQAYDHHLG-GINSITFLENGKRFVTTSDDSSMRFWEYGTPVP---IKFVA 435 Query: 202 KFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKL--ETTLDGHQRWVWDC--A 257 HS R+ L + K +A S D+ V+S + ++ + G+ + Sbjct: 436 DIAMHSMP--RVALRPNGKSIACQSLDNCIYVYSAYEKYRQNKKKVFKGYSCSGYSLEVG 493 Query: 258 FSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 FS D ++ + S WD T +++ + H +A + Sbjct: 494 FSPDGRFVFSGDSSGNACFWDWKTCKLMAKLPAHSGPVQSMAFHP 538 Score = 153 bits (386), Expect = 1e-37, Method: Composition-based stats. Identities = 59/281 (20%), Positives = 105/281 (37%), Gaps = 9/281 (3%) Query: 4 ILVSAGYDHTIRFWEA-LTGVCSRTIQHSDSQVNRLEITNDKK-LLATAGHQNVRLYDIR 61 +L+S D+ I+ WE RT Q + L + D + L+T+ + ++L+D Sbjct: 281 LLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDLSFSQDGRSFLSTSFDKTIKLWDTE 340 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDN-RWMVTSSEDGTIKVWDVRSPSIPRNYKHN-APV 119 + + V D + + D I +D+RSP I + Y H+ + Sbjct: 341 LGKCLNCFNSDRLTNCVK-FQVDPDKPNEFLAGTADKRILQFDIRSPDIVQAYDHHLGGI 399 Query: 120 NEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANT 179 N + N ++ D ++R W+ G + S+ +++ +G +A + Sbjct: 400 NSITFLENGKRFVTTSDDSSMRFWEYGTPVPIKFVADIAMHSMPRVALRPNGKSIACQSL 459 Query: 180 KGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDD 239 YV+ + K V K + S Y + S D + + + + A W Sbjct: 460 DNCIYVYSAYEK-YRQNKKKVFKGYSCSGYSLEVGFSPDGRFVFSGDSSGNACFWDWKT- 517 Query: 240 FKLETTLDGHQRWVWDCAFSADSAYLVTASS--DHYVRLWD 278 KL L H V AF V SS D ++ WD Sbjct: 518 CKLMAKLPAHSGPVQSMAFHPQETSKVATSSIVDGSIKYWD 558 Score = 89.0 bits (219), Expect = 2e-18, Method: Composition-based stats. Identities = 24/105 (22%), Positives = 45/105 (42%), Gaps = 2/105 (1%) Query: 198 KPVTKFRAHSTYITRILLSS-DVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDC 256 K + ++ H+ I+ + L + S D+ ++W + D L T GH R + D Sbjct: 257 KHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTFQGHARPIRDL 316 Query: 257 AFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 +FS D ++ S D ++LWD + + + + CV Sbjct: 317 SFSQDGRSFLSTSFDKTIKLWDTELGKCLNCFNS-DRLTNCVKFQ 360 Score = 80.9 bits (198), Expect = 6e-16, Method: Composition-based stats. Identities = 22/151 (14%), Positives = 47/151 (31%), Gaps = 6/151 (3%) Query: 151 THQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYI 210 G +L + + +WE+ + + F+ H+ I Sbjct: 259 IFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSL-----LRTFQGHARPI 313 Query: 211 TRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAY-LVTAS 269 + S D + + S D T ++W + L D + + Sbjct: 314 RDLSFSQDGRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEFLAGT 373 Query: 270 SDHYVRLWDLSTREIVRQYGGHHKGAVCVAL 300 +D + +D+ + +IV+ Y H G + Sbjct: 374 ADKRILQFDIRSPDIVQAYDHHLGGINSITF 404 Score = 36.2 bits (82), Expect = 0.017, Method: Composition-based stats. Identities = 8/60 (13%), Positives = 19/60 (31%), Gaps = 3/60 (5%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITN-DKKLLATAG--HQNVRLYD 59 + S FW+ T + V + + +AT+ +++ +D Sbjct: 499 RFVFSGDSSGNACFWDWKTCKLMAKLPAHSGPVQSMAFHPQETSKVATSSIVDGSIKYWD 558 >5WLC-LU nrPDB Length = 489 Score = 155 bits (391), Expect = 3e-38, Method: Composition-based stats. Identities = 61/309 (19%), Positives = 114/309 (36%), Gaps = 40/309 (12%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEIT----NDKK--------LLATAGH 52 L + D I++W T + + V L +T +DKK +L+ + Sbjct: 83 LATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPRFHDKKPDLKSQNFMLSCSDD 142 Query: 53 QNVRLYDIR---------------TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDG 97 + V+L+ I T + +F+G + ++N T Sbjct: 143 KTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAF-QGIDSHRENSTFATGGA-- 199 Query: 98 TIKVWDVRSPSIPRNYKHNAP-VNEVVIHPNQG-ELISCDRDGNIRIWDLGENQCTHQLT 155 I +WDV + A + + + N+ L S D +I ++DL N T ++ Sbjct: 200 KIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSDNSIVLYDLRTNSPTQKIV 259 Query: 156 PEDDTSLQSLSMAS-DGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRIL 214 T ++ + AN N Y ++M N + + + F+ H + + + Sbjct: 260 QTMRT--NAICWNPMEAFNFVTANEDHNAYYYDMRNLS-----RSLNVFKDHVSAVMDVD 312 Query: 215 LSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYV 274 S + T S D + R++ + E + V+ +S DS Y+++ S D V Sbjct: 313 FSPTGDEIVTGSYDKSIRIYKTNHGHSREIYHTKRMQHVFQVKYSMDSKYIISGSDDGNV 372 Query: 275 RLWDLSTRE 283 RLW E Sbjct: 373 RLWRSKAWE 381 Score = 111 bits (277), Expect = 5e-25, Method: Composition-based stats. Identities = 38/258 (14%), Positives = 98/258 (37%), Gaps = 28/258 (10%) Query: 3 VILVSAGYDHTIRFW---------------EALTGV--CSRTIQHSDSQVNRLEITNDKK 45 ++S D T++ W +++T RT +S ++ + Sbjct: 134 NFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDG-ESAFQGIDSHRENS 192 Query: 46 LLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQD-NRWMVTSSEDGTIKVWDV 104 AT G + + L+D+ P S+ N+TS+ F Q+ + ++ D +I ++D+ Sbjct: 193 TFATGGAK-IHLWDVNRLKPVSDLSWGA--DNITSLKFNQNETDILASTGSDNSIVLYDL 249 Query: 105 RSPSIPRNYKHNAPVNEVVIHPNQ-GELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQ 163 R+ S + N + +P + ++ + D N +D+ + + + +++ Sbjct: 250 RTNSPTQKIVQTMRTNAICWNPMEAFNFVTANEDHNAYYYDMRNLSRSLNVFKDHVSAVM 309 Query: 164 SLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLA 223 + + G + + + +++ + ++ ++ S D K++ Sbjct: 310 DVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIYHTKRM-----QHVFQVKYSMDSKYII 364 Query: 224 TCSADHTARVWSIDDDFK 241 + S D R+W + Sbjct: 365 SGSDDGNVRLWRSKAWER 382 Score = 105 bits (261), Expect = 3e-23, Method: Composition-based stats. Identities = 50/296 (16%), Positives = 100/296 (33%), Gaps = 46/296 (15%) Query: 30 HSDSQVNRLE--ITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQ-- 85 V + + KL + ++ +++ T SF+ H G VT + Q Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREE--FVSFKAHYGLVTGLCVTQPR 122 Query: 86 ---------DNRWMVTSSEDGTIKVWDVR-----------------SPSIPRNYKHNAPV 119 +M++ S+D T+K+W + + R + + Sbjct: 123 FHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAF 182 Query: 120 NEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGS-MLAAAN 178 + H + I +WD+ + L+ D + SL + + +LA+ Sbjct: 183 QGIDSHRENSTFATGG--AKIHLWDVNRLKPVSDLSWGADN-ITSLKFNQNETDILASTG 239 Query: 179 TKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKH-LATCSADHTARVWSID 237 + + ++++ T++ K V R I + T + DH A + + Sbjct: 240 SDNSIVLYDLR--TNSPTQKIVQTMR-----TNAICWNPMEAFNFVTANEDHNAYYYDMR 292 Query: 238 DDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHK 293 + + H V D FS +VT S D +R++ + Y H K Sbjct: 293 NLSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIY--HTK 346 Score = 76.3 bits (186), Expect = 1e-14, Method: Composition-based stats. Identities = 35/157 (22%), Positives = 61/157 (38%), Gaps = 8/157 (5%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDK--KLLATAGHQNVRLYDIR 61 IL S G D++I ++ T ++ I + N + + + N YD+R Sbjct: 234 ILASTGSDNSIVLYDLRTNSPTQKI-VQTMRTNAICWNPMEAFNFVTANEDHNAYYYDMR 292 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNA---P 118 + F+ H V V F +VT S D +I+++ R H Sbjct: 293 -NLSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHG-HSREIYHTKRMQH 350 Query: 119 VNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLT 155 V +V + +IS DGN+R+W + ++ T Sbjct: 351 VFQVKYSMDSKYIISGSDDGNVRLWRSKAWERSNVKT 387 Score = 42.0 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 15/52 (28%), Positives = 26/52 (50%), Gaps = 1/52 (1%) Query: 248 GHQRWVWDCAFSADS-AYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCV 298 GH+ V+ A + S L T S+D ++ W++STRE + H+ + Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGL 116 Score = 27.3 bits (59), Expect = 7.6, Method: Composition-based stats. Identities = 5/18 (27%), Positives = 9/18 (50%) Query: 2 SVILVSAGYDHTIRFWEA 19 S ++S D +R W + Sbjct: 360 SKYIISGSDDGNVRLWRS 377 >6GMH-W nrPDB Length = 305 Score = 154 bits (389), Expect = 4e-38, Method: Composition-based stats. Identities = 61/236 (25%), Positives = 98/236 (41%), Gaps = 15/236 (6%) Query: 72 EGHRGNVTSVSF----QQDNRWMVTSSEDGTIKVWDVRSPSIPRNY---KHNAPVNEVVI 124 + H + SV++ ++++ +VT S D +KVW R + + H V V I Sbjct: 13 QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDI 72 Query: 125 HPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCY 184 S D +IR+WDL + + +L+ + D LA G Sbjct: 73 SHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGP-VDAWTLAFSPDSQYLATGTHVGKVN 131 Query: 185 VWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLET 244 ++ + + L KF I I S D K+LA+ + D ++ I KL Sbjct: 132 IFGVESGKKEYSLDTRGKF------ILSIAYSPDGKYLASGAIDGIINIFDIATG-KLLH 184 Query: 245 TLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVAL 300 TL+GH + FS DS LVTAS D Y++++D+ + GH + VA Sbjct: 185 TLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAF 240 Score = 152 bits (384), Expect = 2e-37, Method: Composition-based stats. Identities = 65/287 (22%), Positives = 119/287 (41%), Gaps = 16/287 (5%) Query: 22 GVCSRTIQHSDSQVNRLEITNDKK-----LLATAGHQNVRLYDIRTTNPNPVASFEGHRG 76 G+ + Q D + + +KK ++ + V+++ R + S EGH+ Sbjct: 6 GILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQL 65 Query: 77 NVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPV--NEVVIHPNQGELISC 134 V SV +SS D I++WD+ + ++ PV + P+ L + Sbjct: 66 GVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSID-AGPVDAWTLAFSPDSQYLATG 124 Query: 135 DRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDA 194 G + I+ + + + L + S++ + DG LA+ G ++++ Sbjct: 125 THVGKVNIFGVESGKKEYSLD-TRGKFILSIAYSPDGKYLASGAIDGIINIFDI------ 177 Query: 195 SHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVW 254 + K + H+ I + S D + L T S D +++ + L TL GH WV Sbjct: 178 ATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDV-QHANLAGTLSGHASWVL 236 Query: 255 DCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 + AF D + V++SSD V++WD+ TR V + H V N Sbjct: 237 NVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYN 283 Score = 140 bits (354), Expect = 5e-34, Method: Composition-based stats. Identities = 50/282 (17%), Positives = 119/282 (42%), Gaps = 14/282 (4%) Query: 2 SVILVSAGYDHTIRFWEALTGVC--SRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLY 58 S +V+ D ++ W+ +++ V ++I++ + A++ ++RL+ Sbjct: 32 SETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLW 91 Query: 59 DIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHN-A 117 D+ N + S + + +++F D++++ T + G + ++ V S + Sbjct: 92 DLE--NGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGK 149 Query: 118 PVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAA 177 + + P+ L S DG I I+D+ + H L ++SL+ + D +L A Sbjct: 150 FILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHA-MPIRSLTFSPDSQLLVTA 208 Query: 178 NTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSID 237 + G ++++ H H++++ + D H + S+D + +VW + Sbjct: 209 SDDGYIKIYDV------QHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVG 262 Query: 238 DDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDL 279 T HQ VW ++ + + +V+ D + ++D Sbjct: 263 TRT-CVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDC 303 Score = 110 bits (275), Expect = 7e-25, Method: Composition-based stats. Identities = 40/190 (21%), Positives = 86/190 (45%), Gaps = 5/190 (2%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDI 60 S L + + + + +G ++ + + + D K LA+ + ++DI Sbjct: 118 SQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDI 177 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPV 119 T + + EGH + S++F D++ +VT+S+DG IK++DV+ ++ H + V Sbjct: 178 ATGK--LLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWV 235 Query: 120 NEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANT 179 V P+ +S D ++++WD+G C H D + + +GS + + Sbjct: 236 LNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQ-VWGVKYNGNGSKIVSVGD 294 Query: 180 KGNCYVWEMP 189 ++++ P Sbjct: 295 DQEIHIYDCP 304 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 32/199 (16%), Positives = 82/199 (41%), Gaps = 12/199 (6%) Query: 109 IPRNYKHNAPVNEVVI----HPNQGELISCDRDGNIRIWDLGENQCTHQLTPE-DDTSLQ 163 + H+ + V N +++ D +++W + + Q + E + Sbjct: 9 FKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVV 68 Query: 164 SLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLA 223 S+ ++ + A+++ + +W++ N K + A + S D ++LA Sbjct: 69 SVDISHTLPIAASSSLDAHIRLWDLENG------KQIKSIDAGPVDAWTLAFSPDSQYLA 122 Query: 224 TCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTRE 283 T + ++ ++ K E +LD +++ A+S D YL + + D + ++D++T + Sbjct: 123 TGTHVGKVNIFGVESGKK-EYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGK 181 Query: 284 IVRQYGGHHKGAVCVALND 302 ++ GH + + Sbjct: 182 LLHTLEGHAMPIRSLTFSP 200 >5Y88-O nrPDB Length = 451 Score = 153 bits (386), Expect = 9e-38, Method: Composition-based stats. Identities = 58/263 (22%), Positives = 101/263 (38%), Gaps = 16/263 (6%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQN-VRLYDIR 61 L S D T++ W+ R S V + I L+ATAG + ++L+D+R Sbjct: 195 PYLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLDLIATAGRDSVIKLWDMR 254 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNA-PVN 120 T PV + GH+G + V + +V+SS D T+++WDV + + H+ V Sbjct: 255 T--RIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMKVLTHHKRSVR 312 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 +HP + + S D +IR W L E E + +LS+ D + A Sbjct: 313 ATALHPKEFSVASACTD-DIRSWGLAEGSLLTNFESEKTGIINTLSINQDDVLFA-GGDN 370 Query: 181 GNCYVWEMPNHTDASHLKPVTKFRA--HSTYITRILLSSDVKHLATCSADHTARVWSIDD 238 G ++ + L + + L T AD + ++W D+ Sbjct: 371 GVLSFYDYKSGHKYQSLATREMVGSLEGERSVLCSTFDKTGLRLITGEADKSIKIWKQDE 430 Query: 239 DFKLETTLDGHQRWVWDCAFSAD 261 E+ A++ + Sbjct: 431 TATKESEP--------GLAWNPN 445 Score = 150 bits (380), Expect = 5e-37, Method: Composition-based stats. Identities = 52/283 (18%), Positives = 112/283 (39%), Gaps = 21/283 (7%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRTT 63 ++ D T++ W+ TG T+ V + +++ L + + V+ +D+ Sbjct: 155 FITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDVAVSDRHPYLFSVSEDKTVKCWDLEKN 214 Query: 64 NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEV 122 + + GH V +VS + T+ D IK+WD+R+ H P+N+V Sbjct: 215 Q--IIRDYYGHLSGVRTVSIHPTLDLIATAGRDSVIKLWDMRTRIPVITLVGHKGPINQV 272 Query: 123 VIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGN 182 P +++S D +R+WD+ + LT S+++ ++ +A+A T + Sbjct: 273 QCTPVDPQVVSSSTDATVRLWDVVAGKTMKVLT-HHKRSVRATALHPKEFSVASACTD-D 330 Query: 183 CYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFK- 241 W + + ++ + + I + ++ D L + + K Sbjct: 331 IRSWGLAEGSLLTNFESEK-----TGIINTLSINQD-DVLFAGGDNGVLSFYDYKSGHKY 384 Query: 242 -------LETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 + +L+G +R V F L+T +D +++W Sbjct: 385 QSLATREMVGSLEG-ERSVLCSTFDKTGLRLITGEADKSIKIW 426 Score = 136 bits (343), Expect = 1e-32, Method: Composition-based stats. Identities = 57/298 (19%), Positives = 107/298 (35%), Gaps = 25/298 (8%) Query: 17 WEALTGVCSRTIQHSDSQVNRLEITN-DKKLLATAGHQN-VRLYDIRTTNPNPVASFEGH 74 W A SR I V + I D + T + ++++D+ T + GH Sbjct: 125 WHA-PWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLK--TTLAGH 181 Query: 75 RGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRN-YKHNAPVNEVVIHPNQGELIS 133 V V+ + ++ + SED T+K WD+ I R+ Y H + V V IHP + + Sbjct: 182 VMTVRDVAVSDRHPYLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLDLIAT 241 Query: 134 CDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTD 193 RD I++WD+ L + + + +++T +W++ Sbjct: 242 AGRDSVIKLWDMRTRIPVITLVGHKG-PINQVQCTPVDPQVVSSSTDATVRLWDVVAG-- 298 Query: 194 ASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWV 253 K + H + L +A+ D R W + + L T + + + Sbjct: 299 ----KTMKVLTHHKRSVRATALHPKEFSVASACTDD-IRSWGLAEGS-LLTNFESEKTGI 352 Query: 254 WDCAFSADSAYLVTASSDHYVRLWD---------LSTREIVRQYGGHHKGAVCVALND 302 + L + + +D L+TRE+V G + +C + Sbjct: 353 INTLSINQDDVLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEG-ERSVLCSTFDK 409 Score = 82.0 bits (201), Expect = 2e-16, Method: Composition-based stats. Identities = 28/156 (17%), Positives = 51/156 (32%), Gaps = 7/156 (4%) Query: 148 NQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHS 207 + + + D + VW++ + K T H Sbjct: 129 WKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDL------ATGKLKTTLAGHV 182 Query: 208 TYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVT 267 + + +S +L + S D T + W ++ + ++ GH V + + T Sbjct: 183 MTVRDVAVSDRHPYLFSVSEDKTVKCWDLEKN-QIIRDYYGHLSGVRTVSIHPTLDLIAT 241 Query: 268 ASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALNDV 303 A D ++LWD+ TR V GH V V Sbjct: 242 AGRDSVIKLWDMRTRIPVITLVGHKGPINQVQCTPV 277 >5G04-R nrPDB Length = 499 Score = 150 bits (380), Expect = 4e-37, Method: Composition-based stats. Identities = 44/256 (17%), Positives = 93/256 (36%), Gaps = 23/256 (8%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLY--DI 60 L ++ W+ R + ++V L + + ++G ++ ++ D+ Sbjct: 239 NYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNS---YILSSGSRSGHIHHHDV 295 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS-----IPRNYKH 115 R + VA+ GH V + + D R + + D + VW + +H Sbjct: 296 RVAEHH-VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQH 354 Query: 116 NAPVNEVVIHPNQGELISCD---RDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGS 172 V V P Q +++ D +IRIW++ C + S Sbjct: 355 QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKEL 414 Query: 173 MLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTAR 232 + + +W+ P + V + + H++ + + +S D +A+ +AD T R Sbjct: 415 ISGHGFAQNQLVIWKYP------TMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLR 468 Query: 233 VW---SIDDDFKLETT 245 +W +D + E Sbjct: 469 LWRCFELDPARRRERE 484 Score = 128 bits (321), Expect = 3e-30, Method: Composition-based stats. Identities = 54/277 (19%), Positives = 106/277 (38%), Gaps = 13/277 (4%) Query: 32 DSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMV 91 D +N ++ ++ +LA A +V L+ + + + E ++SV++ ++ ++ Sbjct: 184 DYYLNLVDWSS-GNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLA 242 Query: 92 TSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQC 150 + +++WDV+ RN H+A V + N L S R G+I D+ + Sbjct: 243 VGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEH 300 Query: 151 THQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYI 210 + L A DG LA+ VW P+ P+ F H + Sbjct: 301 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW--PSAPGEGGWVPLQTFTQHQGAV 358 Query: 211 TRILLSS-DVKHLATCS--ADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVT 267 + LAT +D R+W++ L D H + V +S L++ Sbjct: 359 KAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAV-DAHSQ-VCSILWSPHYKELIS 416 Query: 268 AS--SDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 + + + +W T V + GH + + ++ Sbjct: 417 GHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSP 453 Score = 90.5 bits (223), Expect = 7e-19, Method: Composition-based stats. Identities = 31/193 (16%), Positives = 70/193 (36%), Gaps = 15/193 (7%) Query: 112 NYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPE-DDTSLQSLSMASD 170 +++ +N V G +++ D ++ +W L E + S++ + Sbjct: 180 EIRNDYYLNLVDWS--SGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKE 237 Query: 171 GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHT 230 G+ LA + +W++ K + +HS + + + L++ S Sbjct: 238 GNYLAVGTSSAEVQLWDV------QQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGH 289 Query: 231 ARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTRE----IVR 286 + TL GH + V ++ D +L + +D+ V +W + E ++ Sbjct: 290 IHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQ 349 Query: 287 QYGGHHKGAVCVA 299 + H VA Sbjct: 350 TFTQHQGAVKAVA 362 Score = 71.6 bits (174), Expect = 4e-13, Method: Composition-based stats. Identities = 24/105 (22%), Positives = 46/105 (43%), Gaps = 6/105 (5%) Query: 2 SVILVSAG--YDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG--HQNVRL 57 S +L + G D IR W +G C + + L + K+L++ G + + Sbjct: 368 SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVI 427 Query: 58 YDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW 102 + T VA +GH V S++ D + +++ D T+++W Sbjct: 428 WKYPT--MAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470 >3ODT-A nrPDB Length = 313 Score = 148 bits (374), Expect = 2e-36, Method: Composition-based stats. Identities = 65/280 (23%), Positives = 124/280 (44%), Gaps = 26/280 (9%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQN----VRLYDI 60 + S D T+R W + +N + ++K+LL G V L+ Sbjct: 32 VASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYDSEKELLLFGGKDTMINGVPLF-- 89 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPV 119 T+ +P+ + GH+GNV S+SFQ +++ S D T KVW + S+ N + HNA V Sbjct: 90 ATSGEDPLYTLIGHQGNVCSLSFQDG--VVISGSWDKTAKVW--KEGSLVYNLQAHNASV 145 Query: 120 N-EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAAN 178 V+ ++ + ++ D I++W ++ + + ++ L++ DG + + + Sbjct: 146 WDAKVVSFSENKFLTASADKTIKLW--QNDKVIKTFSGIHNDVVRHLAVVDDGHFI-SCS 202 Query: 179 TKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDD 238 G + +M + + H +++ I L + + +C D T R+WS ++ Sbjct: 203 NDGLIKLVDM------HTGDVLRTYEGHESFVYCIKLLPNGD-IVSCGEDRTVRIWSKEN 255 Query: 239 D-FKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 K TL W DC + D ++ SSD+ VR++ Sbjct: 256 GSLKQVITLPAISIWSVDCMSNGD---IIVGSSDNLVRIF 292 Score = 100 bits (249), Expect = 8e-22, Method: Composition-based stats. Identities = 44/205 (21%), Positives = 90/205 (43%), Gaps = 14/205 (6%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEIT--NDKKLLATAGHQNVRLYDIR 61 +++S +D T + W+ G +Q ++ V ++ ++ K L + + ++L+ Sbjct: 116 VVISGSWDKTAKVWK--EGSLVYNLQAHNASVWDAKVVSFSENKFLTASADKTIKLW--- 170 Query: 62 TTNPNPVASFEG-HRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPV 119 N + +F G H V ++ D ++ S DG IK+ D+ + + R Y H + V Sbjct: 171 -QNDKVIKTFSGIHNDVVRHLAVVDDG-HFISCSNDGLIKLVDMHTGDVLRTYEGHESFV 228 Query: 120 NEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANT 179 + + PN ++SC D +RIW EN Q+ S+ S+ S+G ++ ++ Sbjct: 229 YCIKLLPNGD-IVSCGEDRTVRIWS-KENGSLKQVITLPAISIWSVDCMSNGDIIV-GSS 285 Query: 180 KGNCYVWEMPNHTDASHLKPVTKFR 204 ++ AS + + R Sbjct: 286 DNLVRIFSQEKSRWASEDEIKGELR 310 Score = 97.4 bits (241), Expect = 7e-21, Method: Composition-based stats. Identities = 48/241 (19%), Positives = 92/241 (38%), Gaps = 22/241 (9%) Query: 66 NPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSI-PRNYKHNAPVNEVVI 124 A+ +GH +V V D++ + + S DGT+++W + Y +N V Sbjct: 9 QLSATLKGHDQDVRDVVAVDDSK-VASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCY 67 Query: 125 HPNQGELISCDRD---GNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKG 181 + L+ +D + ++ + L S++ ++ + + Sbjct: 68 DSEKELLLFGGKDTMINGVPLFATSGEDPLYTLIGHQGNVC---SLSFQDGVVISGSWDK 124 Query: 182 NCYVWEMPNHTDASHLKPVTKFRAHSTYITRILL-SSDVKHLATCSADHTARVWSIDDDF 240 VW+ V +AH+ + + S T SAD T ++W + Sbjct: 125 TAKVWK--------EGSLVYNLQAHNASVWDAKVVSFSENKFLTASADKTIKLW---QND 173 Query: 241 KLETTLDG-HQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVA 299 K+ T G H V A D ++ S+D ++L D+ T +++R Y GH C+ Sbjct: 174 KVIKTFSGIHNDVVRHLAVVDDGH-FISCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIK 232 Query: 300 L 300 L Sbjct: 233 L 233 Score = 27.3 bits (59), Expect = 7.9, Method: Composition-based stats. Identities = 15/43 (34%), Positives = 20/43 (46%), Gaps = 1/43 (2%) Query: 235 SIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 ++L TL GH + V D DS + + S D VRLW Sbjct: 3 DPFTGYQLSATLKGHDQDVRDVVAVDDSK-VASVSRDGTVRLW 44 >4V7E-Bg nrPDB Length = 380 Score = 147 bits (372), Expect = 4e-36, Method: Composition-based stats. Identities = 50/259 (19%), Positives = 91/259 (35%), Gaps = 17/259 (6%) Query: 59 DIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNA 117 T+ + +GH G V S+ + + W+V++S+DG + VW+ + K H Sbjct: 50 SFNPTDLVCCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLHCP 109 Query: 118 PVNEVVIHPNQGELISCDRDGNIRIWDLGENQ-------CTHQLTPEDDTSLQSLSMASD 170 V E PN + D I++L + LT + + Sbjct: 110 WVMECAFAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQ 169 Query: 171 GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSS-DVKHLATCSADH 229 + L + C +W++ S H+ + + ++S + + S D Sbjct: 170 ETRLITGSGDQTCVLWDVTTGQRISIFGSEFP-SGHTADVLSLSINSLNANMFISGSCDT 228 Query: 230 TARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQY- 288 T R+W + + T GH+ + F D T S D RL+D+ T ++ Y Sbjct: 229 TVRLWDLRITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYN 288 Query: 289 ------GGHHKGAVCVALN 301 VA + Sbjct: 289 REPDRNDNELPIVTSVAFS 307 Score = 146 bits (369), Expect = 1e-35, Method: Composition-based stats. Identities = 56/260 (21%), Positives = 104/260 (40%), Gaps = 23/260 (8%) Query: 5 LVSAGYDHTIRFWEALTGV-------CSRTIQHSDSQVNRLEITND--KKLLATAGHQNV 55 + G D + + SR + + + D +L+ +G Q Sbjct: 123 VACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLITGSGDQTC 182 Query: 56 RLYDIRTTNPNPVASFE---GHRGNVTSVSFQQ-DNRWMVTSSEDGTIKVWDVR--SPSI 109 L+D+ T + E GH +V S+S + ++ S D T+++WD+R S ++ Sbjct: 183 VLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDLRITSRAV 242 Query: 110 PRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTS------LQ 163 + H +N V P+ + DG R++D+ E D + + Sbjct: 243 RTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVT 302 Query: 164 SLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLA 223 S++ + G +L A + G+CYVW+ +L + +H I+ + LSSD L Sbjct: 303 SVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQ--NSHEGRISCLGLSSDGSALC 360 Query: 224 TCSADHTARVWSIDDDFKLE 243 T S D ++W+ K+ Sbjct: 361 TGSWDKNLKIWAFSGHRKIV 380 Score = 142 bits (357), Expect = 2e-34, Method: Composition-based stats. Identities = 59/320 (18%), Positives = 108/320 (33%), Gaps = 32/320 (10%) Query: 7 SAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRTTNP 65 S T + VC RT+Q +V L+ T +K + +A + +++ T+ Sbjct: 41 SKAQGRTAVSFNPTDLVCCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQK 100 Query: 66 NPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS--------IPRNYKHNA 117 H V +F + + + D ++++ S + H Sbjct: 101 THAIKL--HCPWVMECAFAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKG 158 Query: 118 PVNEVVIHPNQ-GELISCDRDGNIRIWDLGENQCTHQLTPE----DDTSLQSLSMAS-DG 171 + P+Q LI+ D +WD+ Q E + SLS+ S + Sbjct: 159 YASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNA 218 Query: 172 SMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTA 231 +M + + +W++ + V + H I + D + T S D T Sbjct: 219 NMFISGSCDTTVRLWDLR-----ITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTC 273 Query: 232 RVWSIDDDFKLETTLDGHQRW------VWDCAFSADSAYLVTASSDHYVRLWDLSTREIV 285 R++ + +L+ R V AFS L S+ +WD E+V Sbjct: 274 RLFDMRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMV 333 Query: 286 RQYG----GHHKGAVCVALN 301 G H C+ L+ Sbjct: 334 LNLGTLQNSHEGRISCLGLS 353 Score = 91.3 bits (225), Expect = 5e-19, Method: Composition-based stats. Identities = 31/183 (16%), Positives = 69/183 (37%), Gaps = 19/183 (10%) Query: 133 SCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHT 192 S + ++ + C L + SL + + + +A+ G VW Sbjct: 41 SKAQGRTAVSFNPTDLVCCRTLQGHSGK-VYSLDWTPEKNWIVSASQDGRLIVWN----- 94 Query: 193 DASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI------DDDFKLETTL 246 A + + H ++ + + + +A D ++++ D + + L Sbjct: 95 -ALTSQKTHAIKLHCPWVMECAFAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVL 153 Query: 247 DGHQRWVWDCAFSAD-SAYLVTASSDHYVRLWDLSTREIVRQYG-----GHHKGAVCVAL 300 GH+ + C + D L+T S D LWD++T + + +G GH + +++ Sbjct: 154 TGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSI 213 Query: 301 NDV 303 N + Sbjct: 214 NSL 216 Score = 90.9 bits (224), Expect = 6e-19, Method: Composition-based stats. Identities = 35/157 (22%), Positives = 63/157 (40%), Gaps = 12/157 (7%) Query: 2 SVILVSAGYDHTIRFWEAL-TGVCSRTIQHSDSQVNRLEITNDKK-LLATAGHQNVRLYD 59 + + +S D T+R W+ T RT + +N ++ D + + RL+D Sbjct: 218 ANMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFD 277 Query: 60 IRTTNPNPVASFEGHRGN-----VTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK 114 +RT + V + E R + VTSV+F R + +G VWD + N Sbjct: 278 MRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNLG 337 Query: 115 -----HNAPVNEVVIHPNQGELISCDRDGNIRIWDLG 146 H ++ + + + L + D N++IW Sbjct: 338 TLQNSHEGRISCLGLSSDGSALCTGSWDKNLKIWAFS 374 >4GGA-A nrPDB Length = 420 Score = 147 bits (372), Expect = 4e-36, Method: Composition-based stats. Identities = 44/256 (17%), Positives = 93/256 (36%), Gaps = 23/256 (8%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLY--DI 60 L ++ W+ R + ++V L + + ++G ++ ++ D+ Sbjct: 160 NYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNS---YILSSGSRSGHIHHHDV 216 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS-----IPRNYKH 115 R + VA+ GH V + + D R + + D + VW + +H Sbjct: 217 RVAEHH-VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQH 275 Query: 116 NAPVNEVVIHPNQGELISCD---RDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGS 172 V V P Q +++ D +IRIW++ C + S Sbjct: 276 QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKEL 335 Query: 173 MLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTAR 232 + + +W+ P + V + + H++ + + +S D +A+ +AD T R Sbjct: 336 ISGHGFAQNQLVIWKYP------TMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLR 389 Query: 233 VW---SIDDDFKLETT 245 +W +D + E Sbjct: 390 LWRCFELDPARRRERE 405 Score = 125 bits (313), Expect = 3e-29, Method: Composition-based stats. Identities = 54/277 (19%), Positives = 106/277 (38%), Gaps = 13/277 (4%) Query: 32 DSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMV 91 D +N ++ ++ +LA A +V L+ + + + E ++SV++ ++ ++ Sbjct: 105 DYYLNLVDWSS-GNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLA 163 Query: 92 TSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQC 150 + +++WDV+ RN H+A V + N L S R G+I D+ + Sbjct: 164 VGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEH 221 Query: 151 THQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYI 210 + L A DG LA+ VW P+ P+ F H + Sbjct: 222 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW--PSAPGEGGWVPLQTFTQHQGAV 279 Query: 211 TRILLSS-DVKHLATCS--ADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVT 267 + LAT +D R+W++ L D H + V +S L++ Sbjct: 280 KAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAV-DAHSQ-VCSILWSPHYKELIS 337 Query: 268 AS--SDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 + + + +W T V + GH + + ++ Sbjct: 338 GHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSP 374 Score = 88.6 bits (218), Expect = 3e-18, Method: Composition-based stats. Identities = 31/193 (16%), Positives = 70/193 (36%), Gaps = 15/193 (7%) Query: 112 NYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPE-DDTSLQSLSMASD 170 +++ +N V G +++ D ++ +W L E + S++ + Sbjct: 101 EIRNDYYLNLVDWS--SGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKE 158 Query: 171 GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHT 230 G+ LA + +W++ K + +HS + + + L++ S Sbjct: 159 GNYLAVGTSSAEVQLWDV------QQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGH 210 Query: 231 ARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTRE----IVR 286 + TL GH + V ++ D +L + +D+ V +W + E ++ Sbjct: 211 IHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQ 270 Query: 287 QYGGHHKGAVCVA 299 + H VA Sbjct: 271 TFTQHQGAVKAVA 283 Score = 70.1 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 24/105 (22%), Positives = 46/105 (43%), Gaps = 6/105 (5%) Query: 2 SVILVSAG--YDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG--HQNVRL 57 S +L + G D IR W +G C + + L + K+L++ G + + Sbjct: 289 SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVI 348 Query: 58 YDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW 102 + T VA +GH V S++ D + +++ D T+++W Sbjct: 349 WKYPT--MAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 391 >4L9O-A nrPDB Length = 349 Score = 147 bits (370), Expect = 8e-36, Method: Composition-based stats. Identities = 49/269 (18%), Positives = 94/269 (34%), Gaps = 23/269 (8%) Query: 30 HSDSQVNRLEITNDKK-LLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQD-- 86 D ++ + + L + + +++++I N V + GH G V V++ Sbjct: 67 AHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKF 126 Query: 87 NRWMVTSSEDGTIKVWDVRSPSIPRNYK---HNAPVNEVVIHPN--QGELISCDRDGNIR 141 + + S DG + +W + + + H A VN V P+ L+ DG I Sbjct: 127 GVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKIS 186 Query: 142 IWDLGENQCTHQL-TPEDDTSLQSLSMAS-----DGSMLAAANTKGNCYVWEMPNHTDAS 195 I + + + + + S A + + +W + A Sbjct: 187 IVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDA--AK 244 Query: 196 HLKPVTKFRAHSTYITRILLSSDV---KHLATCSADHTARVWSID----DDFKLETTLDG 248 F+ HS ++ + S ++AT S D T +W+ D K T + Sbjct: 245 TFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEK 304 Query: 249 HQRWVWDCAFSADSAYLVTASSDHYVRLW 277 W ++S L + D+ V LW Sbjct: 305 FPDVCWRASWSLSGNVLAISGGDNKVTLW 333 Score = 110 bits (276), Expect = 5e-25, Method: Composition-based stats. Identities = 44/251 (17%), Positives = 86/251 (34%), Gaps = 22/251 (8%) Query: 5 LVSAGYDHTIRFW--EALTGVCSRTIQHSDSQVNRLEITND--KKLLATAG-HQNVRLYD 59 L + D TI+ + + T+ + V ++ + +LA+ V ++ Sbjct: 84 LATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVLIWK 143 Query: 60 IRTTNPNPVASFEGHRGNVTSVSFQQD--NRWMVTSSEDGTIKVWDVRSPSIPRNY---K 114 N VA H+ +V SVS+ ++ +S DG I + + + Sbjct: 144 EDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISIVEFKDGGALEPIVIQG 203 Query: 115 HNAPVNEVVIHP-----NQGELISCDRDGNIRIW---DLGENQCTHQLTPEDDTSLQSLS 166 H VN P N +S D ++IW D + + ++ ++ Sbjct: 204 HAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSDWVRDVA 263 Query: 167 MAS---DGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLA 223 + S +A A+ +W ++ +P+TK + R S LA Sbjct: 264 WSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKF-PDVCWRASWSLSGNVLA 322 Query: 224 TCSADHTARVW 234 D+ +W Sbjct: 323 ISGGDNKVTLW 333 Score = 99.0 bits (245), Expect = 2e-21, Method: Composition-based stats. Identities = 40/224 (17%), Positives = 79/224 (35%), Gaps = 26/224 (11%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQH--SDSQVNRLEITN---DKKLLATAGHQNVRL 57 VIL S YD + W+ GV ++ +H + VN + LL + + + Sbjct: 128 VILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISI 187 Query: 58 YDIRTTNPNPVASFEGHRGNVTSVSFQQ-----DNRWMVTSSEDGTIKVWDVRSPSIPRN 112 + + +GH V + S+ + R V+ D +K+W R + Sbjct: 188 VEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIW--RYDDAAKT 245 Query: 113 Y-------KHNAPVNEVVIHP---NQGELISCDRDGNIRIW--DLGENQCTHQLTPEDDT 160 + H+ V +V P ++ + + +D + IW D N+ Q ++ Sbjct: 246 FIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKF 305 Query: 161 SLQSL--SMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTK 202 S + G++LA + +W+ V + Sbjct: 306 PDVCWRASWSLSGNVLAISGGDNKVTLWKENIQGKWESAGEVDQ 349 Score = 82.0 bits (201), Expect = 3e-16, Method: Composition-based stats. Identities = 38/203 (18%), Positives = 76/203 (37%), Gaps = 19/203 (9%) Query: 115 HNAPVNEVVIHPNQGELISCDRDGNIRIWDL-GENQCTHQLTPEDDTSLQSLSMASD--G 171 H+ +++ V+ L +C D I+I+++ GENQ + + + ++ A G Sbjct: 68 HDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKFG 127 Query: 172 SMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSD--VKHLATCSADH 229 +LA+ + G +W+ N V + H + + + L S+D Sbjct: 128 VILASCSYDGKVLIWKEDNGV----WNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDG 183 Query: 230 TARVWSIDDDFKLETTL-DGHQRWVWDCAFSA-----DSAYLVTASSDHYVRLWDL---- 279 + D LE + GH V +++ ++ V+ D+ V++W Sbjct: 184 KISIVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAA 243 Query: 280 STREIVRQYGGHHKGAVCVALND 302 T + GH VA + Sbjct: 244 KTFIEEEAFQGHSDWVRDVAWSP 266 Score = 69.7 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 32/105 (30%), Positives = 49/105 (46%), Gaps = 5/105 (4%) Query: 200 VTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSID-DDFKLETTLDGHQRWVWDCAF 258 VT AH I +L + LATCS+D T +++ ID ++ +L TL GH+ VW A+ Sbjct: 62 VTIGNAHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAW 121 Query: 259 SA--DSAYLVTASSDHYVRLW--DLSTREIVRQYGGHHKGAVCVA 299 + L + S D V +W D V ++ H V+ Sbjct: 122 AHPKFGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVS 166 >3JRO-A nrPDB Length = 753 Score = 146 bits (369), Expect = 1e-35, Method: Composition-based stats. Identities = 48/262 (18%), Positives = 95/262 (36%), Gaps = 30/262 (11%) Query: 44 KKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQD--NRWMVTSSEDGTIKV 101 K+L + + ++++++ + + GH G V V + + + S DG + + Sbjct: 22 KRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLI 81 Query: 102 WDVRSP---SIPRNYKHNAPVNEVVIHPN--QGELISCDRDGNIRIWDLGENQCTHQLTP 156 W + I + H+A VN V P+ L+ DG + + + EN T + Sbjct: 82 WKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIII 141 Query: 157 E-DDTSLQSLSMAS-------------DGSMLAAANTKGNCYVWEMPNHTDASHLKPVTK 202 + + S S A + +W+ ++DA + Sbjct: 142 DAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY--NSDAQTYVLEST 199 Query: 203 FRAHSTYITRILLSSD---VKHLATCSADHTARVWSIDD----DFKLETTLDGHQRWVWD 255 HS ++ + S +LA+ S D T +W+ D+ K + +W Sbjct: 200 LEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWR 259 Query: 256 CAFSADSAYLVTASSDHYVRLW 277 ++S L + D+ V LW Sbjct: 260 ASWSLSGNVLALSGGDNKVTLW 281 Score = 122 bits (306), Expect = 2e-28, Method: Composition-based stats. Identities = 60/229 (26%), Positives = 90/229 (39%), Gaps = 25/229 (10%) Query: 73 GHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS---IPRNYKHNAPVNEVVI-HPN- 127 H + + + T S D TIK+++V + I H PV V HP Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 128 QGELISCDRDGNIRIWDLGENQCTHQLTPE--DDTSLQSLSMASD--GSMLAAANTKGNC 183 L SC DG + IW EN Q+ S+ S+ A G +L A++ G Sbjct: 67 GTILASCSYDGKVLIWK-EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125 Query: 184 YVWEMP-NHTDASHLKPVTKFRAHSTYITRILLSSDVKH--------LATCSADHTARVW 234 V E N T + + +S + D +H T AD+ ++W Sbjct: 126 SVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 185 Query: 235 SIDDD---FKLETTLDGHQRWVWDCAFSAD---SAYLVTASSDHYVRLW 277 + D + LE+TL+GH WV D A+S +YL + S D +W Sbjct: 186 KYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 234 Score = 103 bits (256), Expect = 1e-22, Method: Composition-based stats. Identities = 44/230 (19%), Positives = 74/230 (32%), Gaps = 30/230 (13%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQH--SDSQVNRLEITN---DKKLLATAGHQNVRL 57 IL S YD + W+ G S+ H + VN ++ LL + V + Sbjct: 68 TILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 127 Query: 58 YDIRTTNPNPVASFEGHRGNVTSVSFQQ-------------DNRWMVTSSEDGTIKVWDV 104 + + + H V S S+ ++R VT D +K+W Sbjct: 128 VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 187 Query: 105 RSPSIPRNY-----KHNAPVNEVVIHPN---QGELISCDRDGNIRIW--DLGENQCTHQL 154 S + H+ V +V P + L S +D IW D + L Sbjct: 188 NSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTL 247 Query: 155 TPEDDTS--LQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTK 202 E+ L S + G++LA + +W+ V + Sbjct: 248 LKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 297 Score = 87.4 bits (215), Expect = 8e-18, Method: Composition-based stats. Identities = 37/211 (17%), Positives = 75/211 (35%), Gaps = 27/211 (12%) Query: 115 HNAPVNEVVIHPNQGELISCDRDGNIRIWDLG--ENQCTHQLTPEDDTSLQSLSMASD-G 171 HN +++ V+ L +C D I+I+++ ++ LT + + G Sbjct: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG 67 Query: 172 SMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSD--VKHLATCSADH 229 ++LA+ + G +W+ N + + HS + + + L S+D Sbjct: 68 TILASCSYDGKVLIWKEENGRWSQ----IAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 Query: 230 TARVWSI-DDDFKLETTLDGHQRWVWDCAFSA-------------DSAYLVTASSDHYVR 275 V ++ +D H V +++ +S VT +D+ V+ Sbjct: 124 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 Query: 276 LW----DLSTREIVRQYGGHHKGAVCVALND 302 +W D T + GH VA + Sbjct: 184 IWKYNSDAQTYVLESTLEGHSDWVRDVAWSP 214 Score = 71.3 bits (173), Expect = 5e-13, Method: Composition-based stats. Identities = 28/104 (26%), Positives = 43/104 (41%), Gaps = 5/104 (4%) Query: 200 VTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDD-FKLETTLDGHQRWVWDCAF 258 V AH+ I +L K LATCS+D T +++ ++ + KL TL GH+ VW + Sbjct: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 Query: 259 -SAD-SAYLVTASSDHYVRLWDLSTRE--IVRQYGGHHKGAVCV 298 L + S D V +W + + H V Sbjct: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSV 105 Score = 60.5 bits (145), Expect = 8e-10, Method: Composition-based stats. Identities = 15/112 (13%), Positives = 35/112 (31%), Gaps = 11/112 (9%) Query: 2 SVILVSAGYDHTIRFW----EALTGVCSRTIQHSDSQVNRLEITN----DKKLLATAGHQ 53 S V+ G D+ ++ W +A T V T++ V + + L + + + Sbjct: 170 SRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDR 229 Query: 54 NVRLYDIRTTNPNPVASFEGHRGN---VTSVSFQQDNRWMVTSSEDGTIKVW 102 ++ + + S+ + S D + +W Sbjct: 230 TCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 33.9 bits (76), Expect = 0.092, Method: Composition-based stats. Identities = 13/64 (20%), Positives = 23/64 (35%), Gaps = 6/64 (9%) Query: 1 MSVILVSAGYDHTIRFW--EALTGVCSRTIQHSDSQ---VNRLEITNDKKLLA-TAGHQN 54 + L S D T W + G +T+ + + R + +LA + G Sbjct: 218 LRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNK 277 Query: 55 VRLY 58 V L+ Sbjct: 278 VTLW 281 >5LCW-Q nrPDB Length = 374 Score = 145 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 44/256 (17%), Positives = 93/256 (36%), Gaps = 23/256 (8%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLY--DI 60 L ++ W+ R + ++V L + + ++G ++ ++ D+ Sbjct: 114 NYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNS---YILSSGSRSGHIHHHDV 170 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS-----IPRNYKH 115 R + VA+ GH V + + D R + + D + VW + +H Sbjct: 171 RVAEHH-VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQH 229 Query: 116 NAPVNEVVIHPNQGELISCD---RDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGS 172 V V P Q +++ D +IRIW++ C + S Sbjct: 230 QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKEL 289 Query: 173 MLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTAR 232 + + +W+ P + V + + H++ + + +S D +A+ +AD T R Sbjct: 290 ISGHGFAQNQLVIWKYP------TMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLR 343 Query: 233 VW---SIDDDFKLETT 245 +W +D + E Sbjct: 344 LWRCFELDPARRRERE 359 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 54/277 (19%), Positives = 106/277 (38%), Gaps = 13/277 (4%) Query: 32 DSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMV 91 D +N ++ ++ +LA A +V L+ + + + E ++SV++ ++ ++ Sbjct: 59 DYYLNLVDWSS-GNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLA 117 Query: 92 TSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQC 150 + +++WDV+ RN H+A V + N L S R G+I D+ + Sbjct: 118 VGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEH 175 Query: 151 THQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYI 210 + L A DG LA+ VW P+ P+ F H + Sbjct: 176 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW--PSAPGEGGWVPLQTFTQHQGAV 233 Query: 211 TRILLSS-DVKHLATCS--ADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVT 267 + LAT +D R+W++ L D H + V +S L++ Sbjct: 234 KAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAV-DAHSQ-VCSILWSPHYKELIS 291 Query: 268 AS--SDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 + + + +W T V + GH + + ++ Sbjct: 292 GHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSP 328 Score = 87.4 bits (215), Expect = 7e-18, Method: Composition-based stats. Identities = 31/193 (16%), Positives = 70/193 (36%), Gaps = 15/193 (7%) Query: 112 NYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPE-DDTSLQSLSMASD 170 +++ +N V G +++ D ++ +W L E + S++ + Sbjct: 55 EIRNDYYLNLVDWS--SGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKE 112 Query: 171 GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHT 230 G+ LA + +W++ K + +HS + + + L++ S Sbjct: 113 GNYLAVGTSSAEVQLWDV------QQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGH 164 Query: 231 ARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTRE----IVR 286 + TL GH + V ++ D +L + +D+ V +W + E ++ Sbjct: 165 IHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQ 224 Query: 287 QYGGHHKGAVCVA 299 + H VA Sbjct: 225 TFTQHQGAVKAVA 237 Score = 69.3 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 24/105 (22%), Positives = 46/105 (43%), Gaps = 6/105 (5%) Query: 2 SVILVSAG--YDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG--HQNVRL 57 S +L + G D IR W +G C + + L + K+L++ G + + Sbjct: 243 SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVI 302 Query: 58 YDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW 102 + T VA +GH V S++ D + +++ D T+++W Sbjct: 303 WKYPT--MAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 345 >4J0W-A nrPDB Length = 343 Score = 144 bits (363), Expect = 5e-35, Method: Composition-based stats. Identities = 48/279 (17%), Positives = 98/279 (35%), Gaps = 30/279 (10%) Query: 25 SRTIQHSDSQVNRLEITND-KKLLATAGHQNVRLYDIRTTNPNPV---------ASFEGH 74 R ++ + L +T D + + A ++ + + + V GH Sbjct: 7 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 66 Query: 75 RGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQGELIS 133 +V ++ D +++ + I +W+ +S + H V+ + +L S Sbjct: 67 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYS 126 Query: 134 CDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTD 193 D ++++W++ EN L D + +L S + A G VW++P + Sbjct: 127 TSHDRSVKVWNVAENSYVETLFGHQDA-VAALDALSRECCVTAGGRDGTVRVWKIPEESQ 185 Query: 194 ASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGH---- 249 F H I I L + +H+ + + D + +W + L + H Sbjct: 186 L-------VFYGHQGSIDCIHL-INEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRG 237 Query: 250 ------QRWVWDCAFSADSAYLVTASSDHYVRLWDLSTR 282 W+ A ++ + T S VRLW Sbjct: 238 EPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEG 276 Score = 135 bits (340), Expect = 2e-32, Method: Composition-based stats. Identities = 50/284 (17%), Positives = 110/284 (38%), Gaps = 25/284 (8%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQ-----------HSDSQVNRLEITNDKKLLATAGHQ 53 + SA D +I W +G I S V + I++D K LA+ Sbjct: 29 IFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRS 88 Query: 54 N-VRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDV-RSPSIPR 111 + +++ ++ + +F GHR V+ ++F++ + ++S D ++KVW+V + + Sbjct: 89 KLILIWEAQSCQH--LYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVET 146 Query: 112 NYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDG 171 + H V + + + + RDG +R+W + E + S+ + + + Sbjct: 147 LFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL--VFYGHQGSIDCIHL-INE 203 Query: 172 SMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHST-----YITRILLSSDVKHLATCS 226 + + G+ +W + + + R +I+ + + +AT S Sbjct: 204 EHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGS 263 Query: 227 ADHTARVWSIDDDFKLETTLDGHQ--RWVWDCAFSADSAYLVTA 268 R+W + F+ L ++ FS+ +LV Sbjct: 264 HSSCVRLWQCGEGFRQLDLLCDIPLVGFINSLKFSSSGDFLVAG 307 Score = 111 bits (277), Expect = 4e-25, Method: Composition-based stats. Identities = 49/238 (20%), Positives = 90/238 (37%), Gaps = 22/238 (9%) Query: 68 VASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY------------KH 115 + GH+ ++T + D+ + ++++D +I W V S H Sbjct: 7 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 66 Query: 116 NAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLA 175 ++ V + I + L S DR I IW+ Q + T D ++ L+ L Sbjct: 67 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRD-AVSGLAFRRGTHQLY 125 Query: 176 AANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWS 235 + + + VW + ++ V H + + S + D T RVW Sbjct: 126 STSHDRSVKVWNVAENSY------VETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWK 179 Query: 236 IDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHK 293 I ++ +L GHQ + DC + ++V+ + D V LW LS + + H Sbjct: 180 IPEESQLV--FYGHQGSI-DCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHG 234 Score = 98.2 bits (243), Expect = 4e-21, Method: Composition-based stats. Identities = 38/233 (16%), Positives = 82/233 (35%), Gaps = 17/233 (7%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITN-DKKLLATAGHQNVRLYDIRT 62 L S I WEA + T V+ L +L +T+ ++V+++++ Sbjct: 81 YLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAE 140 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEV 122 + V + GH+ V ++ + DGT++VW + S Y H ++ + Sbjct: 141 NSY--VETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQGSIDCI 198 Query: 123 VIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTS----------LQSLSMASDGS 172 + N+ ++S DG++ +W L + + + S++ + Sbjct: 199 HLI-NEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTD 257 Query: 173 MLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATC 225 ++A + +W+ L +I + SS L Sbjct: 258 LVATGSHSSCVRLWQCGEGFRQLDLLCDIPLVG---FINSLKFSSSGDFLVAG 307 Score = 86.3 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 31/147 (21%), Positives = 56/147 (38%), Gaps = 6/147 (4%) Query: 158 DDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKF-----RAHSTYITR 212 S+ L + D S + +A + W + + + K HS+++ Sbjct: 13 HQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLC 72 Query: 213 ILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDH 272 + +SSD K+LA+ +W L T GH+ V AF + L + S D Sbjct: 73 MAISSDGKYLASGDRSKLILIWEAQSCQHL-YTFTGHRDAVSGLAFRRGTHQLYSTSHDR 131 Query: 273 YVRLWDLSTREIVRQYGGHHKGAVCVA 299 V++W+++ V GH + Sbjct: 132 SVKVWNVAENSYVETLFGHQDAVAALD 158 Score = 76.3 bits (186), Expect = 1e-14, Method: Composition-based stats. Identities = 23/116 (19%), Positives = 44/116 (37%), Gaps = 10/116 (8%) Query: 195 SHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKL----------ET 244 + R H IT ++++ D + + + D + WS++ KL E Sbjct: 2 PEAADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEG 61 Query: 245 TLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVAL 300 GH V A S+D YL + + +W+ + + + + GH +A Sbjct: 62 KPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAF 117 >4AEZ-A nrPDB Length = 401 Score = 144 bits (363), Expect = 5e-35, Method: Composition-based stats. Identities = 53/241 (21%), Positives = 95/241 (39%), Gaps = 13/241 (5%) Query: 5 LVSAGY-DHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTT 63 +S G + + ++ + RT+ ++V L N L + + + +D+R Sbjct: 148 FLSVGLGNGLVDIYDVESQTKLRTMAGHQARVGCLSW-NRHVLSSGSRSGAIHHHDVRIA 206 Query: 64 NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK--HNAPVNE 121 N + + +GH V ++++ D + + D +++WD RS SIP+ K HNA V Sbjct: 207 NHQ-IGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARS-SIPKFTKTNHNAAVKA 264 Query: 122 VVIHPNQGELISCD---RDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAAN 178 V P Q L++ D I W+ + + + S S M Sbjct: 265 VAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTVDAGSQVTSLIWSPHSKEIMSTHGF 324 Query: 179 TKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDD 238 N +W +S L AH T + LS D + L+T ++D + W + D Sbjct: 325 PDNNLSIWSY----SSSGLTKQVDIPAHDTRVLYSALSPDGRILSTAASDENLKFWRVYD 380 Query: 239 D 239 Sbjct: 381 G 381 Score = 117 bits (293), Expect = 6e-27, Method: Composition-based stats. Identities = 54/293 (18%), Positives = 116/293 (39%), Gaps = 22/293 (7%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDS-QVNRLEITNDKKLLATA-GHQNVRLYDIRT 62 +V+ + + W A +G S + +S V ++ ++D L+ G+ V +YD+ + Sbjct: 106 VVAVALERNVYVWNADSGSVSALAETDESTYVASVKWSHDGSFLSVGLGNGLVDIYDVES 165 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVR--SPSIPRNYKHNAPVN 120 + + GH+ V +S+ + + + S G I DVR + I H++ V Sbjct: 166 --QTKLRTMAGHQARVGCLSWNR--HVLSSGSRSGAIHHHDVRIANHQIGTLQGHSSEVC 221 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMAS-DGSMLAAAN- 178 + + +L S D ++IWD + T + ++++++ ++LA Sbjct: 222 GLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKTNH-NAAVKAVAWCPWQSNLLATGGG 280 Query: 179 -TKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSA--DHTARVWS 235 + W + + + +T ++ S K + + D+ +WS Sbjct: 281 TMDKQIHFWNAATGARVNTVDA-------GSQVTSLIWSPHSKEIMSTHGFPDNNLSIWS 333 Query: 236 IDD-DFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQ 287 + + H V A S D L TA+SD ++ W + + V++ Sbjct: 334 YSSSGLTKQVDIPAHDTRVLYSALSPDGRILSTAASDENLKFWRVYDGDHVKR 386 Score = 85.1 bits (209), Expect = 3e-17, Method: Composition-based stats. Identities = 29/176 (16%), Positives = 66/176 (37%), Gaps = 8/176 (4%) Query: 124 IHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNC 183 + + +++ + N+ +W+ + ++ T + S+ + DGS L+ G Sbjct: 99 LDWSNLNVVAVALERNVYVWNADSGSVSALAETDESTYVASVKWSHDGSFLSVGLGNGLV 158 Query: 184 YVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLE 243 ++++ + T + H + + + V L++ S + Sbjct: 159 DIYDVESQTKLRTMA------GHQARVGCLSWNRHV--LSSGSRSGAIHHHDVRIANHQI 210 Query: 244 TTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVA 299 TL GH V A+ +D L + +D+ V++WD + H+ VA Sbjct: 211 GTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVA 266 Score = 73.2 bits (178), Expect = 1e-13, Method: Composition-based stats. Identities = 31/172 (18%), Positives = 70/172 (40%), Gaps = 12/172 (6%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITND-KKLLATAG---HQNVRLYDI 60 L S G D+ ++ W+A + + T + ++ V + LLAT G + + ++ Sbjct: 232 LASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNA 291 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVT--SSEDGTIKVWDVRSPSIPRNY---KH 115 T V + + VTS+ + ++ +++ D + +W S + + H Sbjct: 292 ATGAR--VNTVDA-GSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIPAH 348 Query: 116 NAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSM 167 + V + P+ L + D N++ W + + + P T S+++ Sbjct: 349 DTRVLYSALSPDGRILSTAASDENLKFWRVYDGDHVKRPIPITKTPSSSITI 400 Score = 56.6 bits (135), Expect = 1e-08, Method: Composition-based stats. Identities = 28/115 (24%), Positives = 47/115 (40%), Gaps = 6/115 (5%) Query: 2 SVILVSAG--YDHTIRFWEALTGVCSRTIQHSDSQVNRLEITN-DKKLLATAG--HQNVR 56 S +L + G D I FW A TG T+ SQV L + K++++T G N+ Sbjct: 272 SNLLATGGGTMDKQIHFWNAATGARVNTVDAG-SQVTSLIWSPHSKEIMSTHGFPDNNLS 330 Query: 57 LYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPR 111 ++ ++ H V + D R + T++ D +K W V + Sbjct: 331 IWSYSSSGLTKQVDIPAHDTRVLYSALSPDGRILSTAASDENLKFWRVYDGDHVK 385 Score = 48.9 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 16/95 (16%), Positives = 36/95 (37%), Gaps = 2/95 (2%) Query: 207 STYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLV 266 Y+ + S+ + + + VW+ D +V +S D ++L Sbjct: 93 DYYLNLLDWSNLN--VVAVALERNVYVWNADSGSVSALAETDESTYVASVKWSHDGSFLS 150 Query: 267 TASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 + V ++D+ ++ +R GH C++ N Sbjct: 151 VGLGNGLVDIYDVESQTKLRTMAGHQARVGCLSWN 185 >5XYI-g nrPDB Length = 335 Score = 142 bits (359), Expect = 1e-34, Method: Composition-based stats. Identities = 50/300 (16%), Positives = 105/300 (35%), Gaps = 32/300 (10%) Query: 3 VILVSAGYDHTIRFWEALT-----GVCSRTIQHSDSQVNRLEITND-KKLLATAGHQNVR 56 LVSA D + W+ + + V+ + ++ D LL ++ +R Sbjct: 46 NYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVSLSRDASHLLTSSWDSTLR 105 Query: 57 LYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHN 116 L+D+ T + F GH+ +V V+F NR +++ D +K+W++ + + + Sbjct: 106 LWDLSTRTTKKL--FLGHKKDVLGVTFSPCNRRIISVGRDNQVKIWNILGENKA-ELQCS 162 Query: 117 APVNEVVIHPNQGE-----LISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDG 171 + V V P E + DG + IW + + + D S+ DG Sbjct: 163 SWVTSVACAPMADETSPLVIAVGCWDGKVYIWSIEKEAKLIKEFKAHDGRCTSVDFTPDG 222 Query: 172 SMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTA 231 + + +W N + + + + + + Sbjct: 223 KWVITGGSDRKVVMWLTENGAKTISFTA-------PSPVHAVAACPTQAWICAATYEG-I 274 Query: 232 RVWSIDDDFKLETTLD----------GHQRWVWDCAFSADSAYLVTASSDHYVRLWDLST 281 VW I +++ G A++AD + L + +D +R W++ + Sbjct: 275 AVWDIGAKQQIDLVQPNFKHEGKRNAGRTPDCTCLAWAADGSVLYSGYNDGSIRAWEVKS 334 Score = 141 bits (356), Expect = 3e-34, Method: Composition-based stats. Identities = 62/267 (23%), Positives = 118/267 (44%), Gaps = 17/267 (6%) Query: 27 TIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRTTNPN---PVASFEGHRGNVTSVS 82 T ++ + +EI N+ L +A ++ ++ + T P GH V+ VS Sbjct: 28 TFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSDVS 87 Query: 83 FQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQGELISCDRDGNIR 141 +D ++TSS D T+++WD+ + + + + H V V P +IS RD ++ Sbjct: 88 LSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCNRRIISVGRDNQVK 147 Query: 142 IWD-LGENQCTHQLTPEDDTSLQSLSMASDGS--MLAAANTKGNCYVWEMPNHTDASHLK 198 IW+ LGEN+ Q + TS+ MA + S ++A G Y+W + K Sbjct: 148 IWNILGENKAELQCSSW-VTSVACAPMADETSPLVIAVGCWDGKVYIWSIEKEA-----K 201 Query: 199 PVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAF 258 + +F+AH T + + D K + T +D +W ++ K + V A Sbjct: 202 LIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGAKTISFTA--PSPVHAVAA 259 Query: 259 SADSAYLVTASSDHYVRLWDLSTREIV 285 A++ A+ + + +WD+ ++ + Sbjct: 260 CPTQAWICAATYEG-IAVWDIGAKQQI 285 Score = 127 bits (320), Expect = 5e-30, Method: Composition-based stats. Identities = 41/232 (17%), Positives = 84/232 (36%), Gaps = 20/232 (8%) Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS------IPRNYKH 115 + + P A+F GH + S+ ++ ++V++S D + VW + R H Sbjct: 20 SAHFAPRATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGH 79 Query: 116 NAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLA 175 N V++V + + L++ D +R+WDL + ++ + + Sbjct: 80 NHFVSDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKK-DVLGVTFSPCNRRII 138 Query: 176 AANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKH-----LATCSADHT 230 + +W + A S+++T + + +A D Sbjct: 139 SVGRDNQVKIWNILGENKAELQC--------SSWVTSVACAPMADETSPLVIAVGCWDGK 190 Query: 231 ARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTR 282 +WSI+ + KL H F+ D +++T SD V +W Sbjct: 191 VYIWSIEKEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENG 242 Score = 87.8 bits (216), Expect = 6e-18, Method: Composition-based stats. Identities = 36/113 (31%), Positives = 60/113 (53%), Gaps = 4/113 (3%) Query: 194 ASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETT----LDGH 249 ++H P F H+ I I + ++ +L + S D +A VW ++ + T L GH Sbjct: 20 SAHFAPRATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGH 79 Query: 250 QRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 +V D + S D+++L+T+S D +RLWDLSTR + + GH K + V + Sbjct: 80 NHFVSDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSP 132 >4N14-A nrPDB Length = 314 Score = 140 bits (354), Expect = 6e-34, Method: Composition-based stats. Identities = 42/242 (17%), Positives = 89/242 (36%), Gaps = 20/242 (8%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLY--DI 60 L ++ W+ R + ++V L + + ++G ++ ++ D+ Sbjct: 76 NYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNS---YILSSGSRSGHIHHHDV 132 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS-----IPRNYKH 115 R + VA+ GH V + + D R + + D + VW + +H Sbjct: 133 RVAEHH-VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQH 191 Query: 116 NAPVNEVVIHPNQGELISCD---RDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGS 172 V V P Q +++ D +IRIW++ C + S Sbjct: 192 QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKEL 251 Query: 173 MLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTAR 232 + + +W+ P + V + + H++ + + +S D +A+ +AD T R Sbjct: 252 ISGHGFAQNQLVIWKYP------TMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLR 305 Query: 233 VW 234 +W Sbjct: 306 LW 307 Score = 119 bits (297), Expect = 2e-27, Method: Composition-based stats. Identities = 54/277 (19%), Positives = 106/277 (38%), Gaps = 13/277 (4%) Query: 32 DSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMV 91 D +N ++ ++ +LA A +V L+ + + + E ++SV++ ++ ++ Sbjct: 21 DYYLNLVDWSS-GNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLA 79 Query: 92 TSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQC 150 + +++WDV+ RN H+A V + N L S R G+I D+ + Sbjct: 80 VGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEH 137 Query: 151 THQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYI 210 + L A DG LA+ VW P+ P+ F H + Sbjct: 138 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW--PSAPGEGGWVPLQTFTQHQGAV 195 Query: 211 TRILLSS-DVKHLATCS--ADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVT 267 + LAT +D R+W++ L D H + V +S L++ Sbjct: 196 KAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAV-DAHSQ-VCSILWSPHYKELIS 253 Query: 268 AS--SDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 + + + +W T V + GH + + ++ Sbjct: 254 GHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSP 290 Score = 84.4 bits (207), Expect = 6e-17, Method: Composition-based stats. Identities = 31/193 (16%), Positives = 70/193 (36%), Gaps = 15/193 (7%) Query: 112 NYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPE-DDTSLQSLSMASD 170 +++ +N V G +++ D ++ +W L E + S++ + Sbjct: 17 EIRNDYYLNLVDWS--SGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKE 74 Query: 171 GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHT 230 G+ LA + +W++ K + +HS + + + L++ S Sbjct: 75 GNYLAVGTSSAEVQLWDV------QQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGH 126 Query: 231 ARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTRE----IVR 286 + TL GH + V ++ D +L + +D+ V +W + E ++ Sbjct: 127 IHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQ 186 Query: 287 QYGGHHKGAVCVA 299 + H VA Sbjct: 187 TFTQHQGAVKAVA 199 Score = 67.0 bits (162), Expect = 9e-12, Method: Composition-based stats. Identities = 24/105 (22%), Positives = 46/105 (43%), Gaps = 6/105 (5%) Query: 2 SVILVSAG--YDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG--HQNVRL 57 S +L + G D IR W +G C + + L + K+L++ G + + Sbjct: 205 SNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVI 264 Query: 58 YDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW 102 + T VA +GH V S++ D + +++ D T+++W Sbjct: 265 WKYPT--MAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 307 >5WJC-A nrPDB Length = 430 Score = 140 bits (352), Expect = 9e-34, Method: Composition-based stats. Identities = 55/286 (19%), Positives = 114/286 (39%), Gaps = 44/286 (15%) Query: 31 SDSQVNRLEITNDK-KLLATAGHQ-NVRLYD------IRTTNPNPVASFEGHRGNVTSVS 82 D VNR K +++AT G N ++D + T P A +GH + Sbjct: 130 HDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLC 189 Query: 83 FQQDNRW-MVTSSEDGTIKVWDVRSPS-----------IPRNYKHNAPVNEVVIHPNQGE 130 + + + T +ED I +WDV++ S I + ++H VN+V HP Sbjct: 190 WNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEA 249 Query: 131 LI-SCDRDGNIRIWD--LGENQCTHQLTPEDDTSLQSLSMAS-DGSMLAAANTKGNCYVW 186 L+ S D ++I D L + ++ ++ ++++ + +LA A+ +W Sbjct: 250 LLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALW 309 Query: 187 EMPNHTDASHLKPVTKFRAHSTYITRILLSS-DVKHLATCSADHTARVWSIDD------- 238 ++ N + + H + + S D LA+ S D +W ++ Sbjct: 310 DLRNP-----YQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTP 364 Query: 239 ------DFKLETTLDGHQRWVWDCAFSADSAYLV-TASSDHYVRLW 277 +L GH + + ++ + ++V + + D+ +++W Sbjct: 365 EDAEDGSPELLFMHGGHTNRISEFSWCPNERWVVGSLADDNILQIW 410 Score = 120 bits (301), Expect = 7e-28, Method: Composition-based stats. Identities = 53/263 (20%), Positives = 101/263 (38%), Gaps = 40/263 (15%) Query: 74 HRGNVTSVSFQQDNRWMV-TSSEDGTIKVWDVR-------SPSIPRNY--KHNAPVNEVV 123 H G+V + ++ T E G ++D ++P+ H A + Sbjct: 130 HDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLC 189 Query: 124 IHPNQ-GELISCDRDGNIRIWDLGENQCTHQLTPE---------DDTSLQSLSMAS-DGS 172 +PN G L + D I +WD+ T T + + + Sbjct: 190 WNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEA 249 Query: 173 MLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSS-DVKHLATCSADHTA 231 +LA+ + + + + + K + +AHS I + ++ + LAT SAD T Sbjct: 250 LLASVSDDCTLQIHDTRLNPEEEAPKVI---QAHSKAINAVAINPFNDYLLATASADKTV 306 Query: 232 RVWSIDDDFKLETTLDGHQRWVWDCAFSA-DSAYLVTASSDHYVRLWDL----------- 279 +W + + ++ TL+GH+ V+ +S D L ++S+D V +WDL Sbjct: 307 ALWDLRNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPED 366 Query: 280 ---STREIVRQYGGHHKGAVCVA 299 + E++ +GGH + Sbjct: 367 AEDGSPELLFMHGGHTNRISEFS 389 Score = 105 bits (261), Expect = 3e-23, Method: Composition-based stats. Identities = 39/249 (15%), Positives = 81/249 (32%), Gaps = 53/249 (21%) Query: 5 LVSAGYDHTIRFWEALTGVCSRT----------IQHSDSQVNRLEITNDKK-LLATAGHQ 53 L + D I W+ T + + VN ++ + LLA+ Sbjct: 198 LATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEALLASVSDD 257 Query: 54 -NVRLYDIRTT-NPNPVASFEGHRGNVTSVSFQQDNRW-MVTSSEDGTIKVWDVRS--PS 108 ++++D R + H + +V+ N + + T+S D T+ +WD+R+ Sbjct: 258 CTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALWDLRNPYQR 317 Query: 109 IPRNYKHNAPVNEVVIHPN-QGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSM 167 + H V + P+ + L S D + IWDL + +D S Sbjct: 318 LHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDGS------ 371 Query: 168 ASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLA-TCS 226 + + H+ I+ + + + + + Sbjct: 372 -----------------------------PELLFMHGGHTNRISEFSWCPNERWVVGSLA 402 Query: 227 ADHTARVWS 235 D+ ++WS Sbjct: 403 DDNILQIWS 411 Score = 89.4 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 41/213 (19%), Positives = 78/213 (36%), Gaps = 18/213 (8%) Query: 108 SIPRNYKHNAPVNEVVIHPNQGELISC-DRDGNIRIWD------LGENQCTHQ-LTPEDD 159 I + H+ VN P + E+I+ GN I+D L + Q + Sbjct: 123 EISQKIPHDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHT 182 Query: 160 TSLQSLSMASDGS-MLAAANTKGNCYVWEMPNHTDASH----LKPVTKFRAHSTYITRIL 214 L + LA +W++ + S + P+ K+ H+ + + Sbjct: 183 AEGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQ 242 Query: 215 LSSDVK-HLATCSADHTARVWS--IDDDFKLETTLDGHQRWVWDCAFSADSAYL-VTASS 270 + LA+ S D T ++ ++ + + + H + + A + + YL TAS+ Sbjct: 243 FHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASA 302 Query: 271 DHYVRLWDLST-REIVRQYGGHHKGAVCVALND 302 D V LWDL + + GH + + Sbjct: 303 DKTVALWDLRNPYQRLHTLEGHEDEVYGLEWSP 335 Score = 85.1 bits (209), Expect = 3e-17, Method: Composition-based stats. Identities = 32/163 (19%), Positives = 59/163 (36%), Gaps = 23/163 (14%) Query: 4 ILVSAGYDHTIRFWEALTG---VCSRTIQHSDSQVNRLEITNDKKLL--ATAGHQNVRLY 58 +L S D T++ + + IQ +N + I L + + V L+ Sbjct: 250 LLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALW 309 Query: 59 DIRTTNPNPVASFEGHRGNVTSVSFQQ-DNRWMVTSSEDGTIKVWDVRS----------- 106 D+R + + EGH V + + D + +SS D + +WD+ Sbjct: 310 DLR-NPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAE 368 Query: 107 -PSIPRNYKHNAPVNEV---VIHPNQGELI-SCDRDGNIRIWD 144 S + H N + PN+ ++ S D ++IW Sbjct: 369 DGSPELLFMHGGHTNRISEFSWCPNERWVVGSLADDNILQIWS 411 Score = 45.1 bits (105), Expect = 4e-05, Method: Composition-based stats. Identities = 16/102 (15%), Positives = 34/102 (33%), Gaps = 30/102 (29%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRT 62 IL S+ D + W+ +T + D Sbjct: 339 PILASSSTDRRVCIWDLEKIGEEQTPE-----------------------------DAED 369 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMV-TSSEDGTIKVWD 103 +P + GH ++ S+ + RW+V + ++D +++W Sbjct: 370 GSPELLFMHGGHTNRISEFSWCPNERWVVGSLADDNILQIWS 411 >5OV3-A nrPDB Length = 381 Score = 140 bits (352), Expect = 1e-33, Method: Composition-based stats. Identities = 58/269 (21%), Positives = 108/269 (40%), Gaps = 20/269 (7%) Query: 37 RLEITNDKKLLA-TAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSE 95 LLA + ++D T + H V S+ + +D +V++S Sbjct: 30 TCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKI--ISAHIHPVCSLCWSRDGHKLVSAST 87 Query: 96 DGTIKVWDVRSPSIPRNYKHNAPVNEVVIHP-NQGELISCDRDGNIRIWDLGENQCTHQL 154 D + WDV S + ++ +P+ +V HP +Q +++ C + L +++ H + Sbjct: 88 DNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSK--HVV 145 Query: 155 TPEDDTSLQSLSMASD--GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITR 212 P DD S ++ + D G + N KG V + + + + VT +++T I Sbjct: 146 LPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFR-VTTGTSNTTAIKS 204 Query: 213 ILLSSDVKHLATCSADHTARVWSID---------DDFKLETTLDGHQRWVW-DCAFSADS 262 I + +AD RV+ + ++ D R W C FS D Sbjct: 205 IEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDG 264 Query: 263 AYLVTASS-DHYVRLWDLSTREIVRQYGG 290 Y+V S+ H + +W+ S +V+ G Sbjct: 265 EYIVAGSARQHALYIWEKSIGNLVKILHG 293 Score = 32.7 bits (73), Expect = 0.18, Method: Composition-based stats. Identities = 10/44 (22%), Positives = 16/44 (36%) Query: 255 DCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCV 298 C F+ L +D + +WD TR I + H + Sbjct: 30 TCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSL 73 >5A31-R nrPDB Length = 386 Score = 138 bits (348), Expect = 3e-33, Method: Composition-based stats. Identities = 40/239 (16%), Positives = 94/239 (39%), Gaps = 14/239 (5%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTN 64 L + + ++ + C RT+ +V L + T+G ++ R+ Sbjct: 146 LAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSW---NNHVLTSGSRDHRILHRDVRM 202 Query: 65 PNPV-ASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEV 122 P+P + E H V + + + + + D + V++ S S + +H A V + Sbjct: 203 PDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAM 262 Query: 123 VIHPNQGELISCD---RDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANT 179 P++ +++ D ++IW++ + + S ++ + + + Sbjct: 263 AWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYS 322 Query: 180 KGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDD 238 K N +W+ + + P+ + HS + + LS+D + + + D T R W + D Sbjct: 323 KYNLTLWDCNS------MDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKLFD 375 Score = 101 bits (252), Expect = 4e-22, Method: Composition-based stats. Identities = 47/286 (16%), Positives = 97/286 (33%), Gaps = 22/286 (7%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATA-GHQNVRLYDI 60 S +++ +I + TG + ++++ L LA + V +YD+ Sbjct: 102 STDVLAVALGKSIFLTDNNTGDVVH-LCDTENEYTSLSWIGAGSHLAVGQANGLVEIYDV 160 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY--KHNAP 118 + + GH V +S+ +N + + S D I DVR P H Sbjct: 161 --MKRKCIRTLSGHIDRVACLSW--NNHVLTSGSRDHRILHRDVRMPDPFFETIESHTQE 216 Query: 119 VNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGS-MLAAA 177 V + + +L S D + +++ ++++++ + +LA Sbjct: 217 VCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHK-AAVKAMAWSPHKRGVLATG 275 Query: 178 N--TKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLAT--CSADHTARV 233 +W + S + + I ++ S + L T + + + Sbjct: 276 GGTADRRLKIWNVNTSIKMSDIDS-------GSQICNMVWSKNTNELVTSHGYSKYNLTL 328 Query: 234 WSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDL 279 W + L GH V S D +V+ + D +R W L Sbjct: 329 WDC-NSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKL 373 Score = 95.1 bits (235), Expect = 3e-20, Method: Composition-based stats. Identities = 45/234 (19%), Positives = 88/234 (37%), Gaps = 16/234 (6%) Query: 75 RGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQGELIS 133 TS+S+ + +G ++++DV R H V + N L S Sbjct: 131 ENEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSW--NNHVLTS 188 Query: 134 CDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTD 193 RD I D+ + + L + LA+ +V+E + + Sbjct: 189 GSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKS- 247 Query: 194 ASHLKPVTKFRAHSTYITRILLSSDVK-HLATCS--ADHTARVWSIDDDFKLETTLDGHQ 250 P+ F H + + S + LAT AD ++W+++ K+ G Q Sbjct: 248 -----PILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQ 302 Query: 251 RWVWDCAFSADSAYLVT--ASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 + + +S ++ LVT S + + LWD ++ + + GH + + L++ Sbjct: 303 --ICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSN 354 Score = 75.1 bits (183), Expect = 3e-14, Method: Composition-based stats. Identities = 27/179 (15%), Positives = 64/179 (35%), Gaps = 10/179 (5%) Query: 124 IHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNC 183 I + ++++ +I + D H E++ SLS GS LA G Sbjct: 98 IDWSSTDVLAVALGKSIFLTDNNTGDVVHLCDTENEY--TSLSWIGAGSHLAVGQANGLV 155 Query: 184 YVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLE 243 ++++ K + H + + + L + S DH + Sbjct: 156 EIYDVMKR------KCIRTLSGHIDRVACLSW--NNHVLTSGSRDHRILHRDVRMPDPFF 207 Query: 244 TTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 T++ H + V ++ L + +D+ V +++ +++ + + H +A + Sbjct: 208 ETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSP 266 Score = 60.1 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 27/158 (17%), Positives = 62/158 (39%), Gaps = 10/158 (6%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKK-LLATAG---HQNVRLYDI 60 L S G D+ + +E + T + V + + K+ +LAT G + ++++++ Sbjct: 229 LASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNV 288 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVT--SSEDGTIKVWDVRSPSIPRNYK-HNA 117 T+ + ++ + ++ +VT + +WD S K H+ Sbjct: 289 NTSIKMSDIDS---GSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSF 345 Query: 118 PVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLT 155 V + + + ++S D +R W L + + T Sbjct: 346 RVLHLTLSNDGTTVVSGAGDETLRYWKLFDVSVLNLFT 383 Score = 58.5 bits (140), Expect = 3e-09, Method: Composition-based stats. Identities = 24/114 (21%), Positives = 50/114 (43%), Gaps = 6/114 (5%) Query: 4 ILVSAG--YDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQ--NVRLYD 59 +L + G D ++ W T + I N + N +L+ + G+ N+ L+D Sbjct: 271 VLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWD 330 Query: 60 IRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY 113 + +P+A +GH V ++ D +V+ + D T++ W + S+ + Sbjct: 331 CNS--MDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKLFDVSVLNLF 382 >3JRP-A nrPDB Length = 379 Score = 137 bits (346), Expect = 4e-33, Method: Composition-based stats. Identities = 48/262 (18%), Positives = 95/262 (36%), Gaps = 30/262 (11%) Query: 44 KKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQD--NRWMVTSSEDGTIKV 101 K+L + + ++++++ + + GH G V V + + + S DG + + Sbjct: 24 KRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLI 83 Query: 102 WDVRSP---SIPRNYKHNAPVNEVVIHPN--QGELISCDRDGNIRIWDLGENQCTHQLTP 156 W + I + H+A VN V P+ L+ DG + + + EN T + Sbjct: 84 WKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIII 143 Query: 157 E-DDTSLQSLSMAS-------------DGSMLAAANTKGNCYVWEMPNHTDASHLKPVTK 202 + + S S A + +W+ ++DA + Sbjct: 144 DAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY--NSDAQTYVLEST 201 Query: 203 FRAHSTYITRILLSSD---VKHLATCSADHTARVWSIDD----DFKLETTLDGHQRWVWD 255 HS ++ + S +LA+ S D T +W+ D+ K + +W Sbjct: 202 LEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWR 261 Query: 256 CAFSADSAYLVTASSDHYVRLW 277 ++S L + D+ V LW Sbjct: 262 ASWSLSGNVLALSGGDNKVTLW 283 Score = 114 bits (286), Expect = 4e-26, Method: Composition-based stats. Identities = 60/229 (26%), Positives = 90/229 (39%), Gaps = 25/229 (10%) Query: 73 GHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS---IPRNYKHNAPVNEVVI-HPN- 127 H + + + T S D TIK+++V + I H PV V HP Sbjct: 9 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 68 Query: 128 QGELISCDRDGNIRIWDLGENQCTHQLTPE--DDTSLQSLSMASD--GSMLAAANTKGNC 183 L SC DG + IW EN Q+ S+ S+ A G +L A++ G Sbjct: 69 GTILASCSYDGKVLIWK-EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 127 Query: 184 YVWEMP-NHTDASHLKPVTKFRAHSTYITRILLSSDVKH--------LATCSADHTARVW 234 V E N T + + +S + D +H T AD+ ++W Sbjct: 128 SVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 187 Query: 235 SIDDD---FKLETTLDGHQRWVWDCAFSAD---SAYLVTASSDHYVRLW 277 + D + LE+TL+GH WV D A+S +YL + S D +W Sbjct: 188 KYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 236 Score = 96.7 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 44/230 (19%), Positives = 74/230 (32%), Gaps = 30/230 (13%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQH--SDSQVNRLEITN---DKKLLATAGHQNVRL 57 IL S YD + W+ G S+ H + VN ++ LL + V + Sbjct: 70 TILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 129 Query: 58 YDIRTTNPNPVASFEGHRGNVTSVSFQQ-------------DNRWMVTSSEDGTIKVWDV 104 + + + H V S S+ ++R VT D +K+W Sbjct: 130 VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 189 Query: 105 RSPSIPRNY-----KHNAPVNEVVIHPN---QGELISCDRDGNIRIW--DLGENQCTHQL 154 S + H+ V +V P + L S +D IW D + L Sbjct: 190 NSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTL 249 Query: 155 TPEDDTS--LQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTK 202 E+ L S + G++LA + +W+ V + Sbjct: 250 LKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 299 Score = 81.3 bits (199), Expect = 4e-16, Method: Composition-based stats. Identities = 37/211 (17%), Positives = 75/211 (35%), Gaps = 27/211 (12%) Query: 115 HNAPVNEVVIHPNQGELISCDRDGNIRIWDLG--ENQCTHQLTPEDDTSLQSLSMASD-G 171 HN +++ V+ L +C D I+I+++ ++ LT + + G Sbjct: 10 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG 69 Query: 172 SMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSD--VKHLATCSADH 229 ++LA+ + G +W+ N + + HS + + + L S+D Sbjct: 70 TILASCSYDGKVLIWKEENGRWSQ----IAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 125 Query: 230 TARVWSI-DDDFKLETTLDGHQRWVWDCAFSA-------------DSAYLVTASSDHYVR 275 V ++ +D H V +++ +S VT +D+ V+ Sbjct: 126 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 185 Query: 276 LW----DLSTREIVRQYGGHHKGAVCVALND 302 +W D T + GH VA + Sbjct: 186 IWKYNSDAQTYVLESTLEGHSDWVRDVAWSP 216 Score = 67.4 bits (163), Expect = 8e-12, Method: Composition-based stats. Identities = 28/104 (26%), Positives = 43/104 (41%), Gaps = 5/104 (4%) Query: 200 VTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDD-FKLETTLDGHQRWVWDCAF 258 V AH+ I +L K LATCS+D T +++ ++ + KL TL GH+ VW + Sbjct: 4 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 63 Query: 259 -SAD-SAYLVTASSDHYVRLWDLSTRE--IVRQYGGHHKGAVCV 298 L + S D V +W + + H V Sbjct: 64 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSV 107 Score = 57.0 bits (136), Expect = 9e-09, Method: Composition-based stats. Identities = 15/112 (13%), Positives = 35/112 (31%), Gaps = 11/112 (9%) Query: 2 SVILVSAGYDHTIRFW----EALTGVCSRTIQHSDSQVNRLEITN----DKKLLATAGHQ 53 S V+ G D+ ++ W +A T V T++ V + + L + + + Sbjct: 172 SRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDR 231 Query: 54 NVRLYDIRTTNPNPVASFEGHRGN---VTSVSFQQDNRWMVTSSEDGTIKVW 102 ++ + + S+ + S D + +W Sbjct: 232 TCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 283 Score = 31.6 bits (70), Expect = 0.38, Method: Composition-based stats. Identities = 13/64 (20%), Positives = 23/64 (35%), Gaps = 6/64 (9%) Query: 1 MSVILVSAGYDHTIRFW--EALTGVCSRTIQHSDSQ---VNRLEITNDKKLLA-TAGHQN 54 + L S D T W + G +T+ + + R + +LA + G Sbjct: 220 LRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNK 279 Query: 55 VRLY 58 V L+ Sbjct: 280 VTLW 283 >6BX3-A nrPDB Length = 314 Score = 137 bits (346), Expect = 5e-33, Method: Composition-based stats. Identities = 45/280 (16%), Positives = 109/280 (38%), Gaps = 20/280 (7%) Query: 36 NRLEITNDKKLLATAGHQNVRLYDI--RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTS 93 +I+ D + LA N+ +YDI RT + V S H + + + D + + T+ Sbjct: 16 TCAKISPDGQFLAITQGLNILIYDINRRTVSQTLVTS---HARPFSELCWSPDGQCIATA 72 Query: 94 SEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQ 153 S+D ++++ + + H APV + + L + D +I+IWD Sbjct: 73 SDDFSVEIIHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKT 132 Query: 154 LTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHST--YIT 211 ++ + + +D S+L++ + G +++ L ++ + I+ Sbjct: 133 ISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPIS 192 Query: 212 RILLSSDVKHLATCSADHTARVWS-----IDDDFKLETTLDGHQRWVWDCAF----SADS 262 ++ S + ++L S D ++W + F+++ G F + Sbjct: 193 QVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGST 252 Query: 263 AYLVTASSDHYVRLWDLSTREIVRQYGG----HHKGAVCV 298 +++ + + W+ T+ +++ G H + + Sbjct: 253 PLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSI 292 Score = 117 bits (292), Expect = 8e-27, Method: Composition-based stats. Identities = 55/284 (19%), Positives = 103/284 (36%), Gaps = 23/284 (8%) Query: 14 IRFWEALTGVCSRTI-QHSDSQVNRLEITNDKKLLATAGHQ-NVRLYDIRTTNPNPVASF 71 I ++ S+T+ + L + D + +ATA +V + + + +F Sbjct: 35 ILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVEIIHLSYG---LLHTF 91 Query: 72 EGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGE 130 GH V S++F + + TSS D +IK+WD + S+ + H+ V V + N Sbjct: 92 IGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSS 151 Query: 131 LI-SCDRDGNIRIWDLGENQCTHQLTPEDD-------TSLQSLSMASDGSMLAAANTKGN 182 ++ S DG IRI+D C LT + D + + + + L + G Sbjct: 152 ILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGV 211 Query: 183 CYVWEMPNHTDASHL--KPVTKFRAHSTYITRILLSSDVK--HLATCSADHTARVWSIDD 238 +W+ +P+ K H + L D + + + W+ D Sbjct: 212 VKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDT 271 Query: 239 DFKLET---TLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDL 279 L+ +L H V + + + + LW Sbjct: 272 KSLLQLLDGSLYHHSSPVMSI--HCFGNIMCSLALNGDCCLWRW 313 Score = 108 bits (269), Expect = 4e-24, Method: Composition-based stats. Identities = 40/207 (19%), Positives = 87/207 (42%), Gaps = 22/207 (10%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLE-ITNDKKLLATAG-HQNVRLYDI 60 +L ++ D +I+ W+ L G +TI V ++ ND +L++ +R++D Sbjct: 108 NLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDA 167 Query: 61 RTTNPNPVASFEGH------RGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK 114 T + +++ ++ V F ++ R+++ S DG +K+WD + R ++ Sbjct: 168 ETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQ 227 Query: 115 HNAPVNEVVIHP------------NQGELISCDRDGNIRIWDLGENQCTHQLTPED-DTS 161 P+ + V+H + +IS +G+I W+ L S Sbjct: 228 VQ-PLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHS 286 Query: 162 LQSLSMASDGSMLAAANTKGNCYVWEM 188 +S+ G+++ + G+C +W Sbjct: 287 SPVMSIHCFGNIMCSLALNGDCCLWRW 313 Score = 99.4 bits (246), Expect = 2e-21, Method: Composition-based stats. Identities = 41/235 (17%), Positives = 82/235 (34%), Gaps = 25/235 (10%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQ-NVRLYDIRTT 63 + +A D ++ G T + V L LL T+ +++++D T Sbjct: 69 IATASDDFSVEIIHLSYG-LLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWD--TL 125 Query: 64 NPNPVASFEGHRGNVTSVSF-QQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNA----- 117 N + + + H V SV D+ + + S DG I+++D + + ++ Sbjct: 126 NGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRE 185 Query: 118 ----PVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPE-------DDTSLQSLS 166 P+++V N L+ DG ++IWD + + Sbjct: 186 NGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFL 245 Query: 167 MASDGS--MLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDV 219 DGS ++ + G+ Y W + L HS+ + I ++ Sbjct: 246 NPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLD--GSLYHHSSPVMSIHCFGNI 298 Score = 84.4 bits (207), Expect = 5e-17, Method: Composition-based stats. Identities = 30/138 (21%), Positives = 56/138 (40%), Gaps = 8/138 (5%) Query: 163 QSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHL 222 ++ DG LA N ++++ T + L +H+ + + S D + + Sbjct: 16 TCAKISPDGQFLAI-TQGLNILIYDINRRTVSQTL-----VTSHARPFSELCWSPDGQCI 69 Query: 223 ATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTR 282 AT S D + + I + L T GH V F+ L T+S D +++WD Sbjct: 70 ATASDDFSVEI--IHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNG 127 Query: 283 EIVRQYGGHHKGAVCVAL 300 +++ H + V V + Sbjct: 128 SLMKTISAHSEAVVSVDV 145 Score = 65.1 bits (157), Expect = 4e-11, Method: Composition-based stats. Identities = 34/166 (20%), Positives = 69/166 (41%), Gaps = 28/166 (16%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTI--------QHSDSQVNRLEITNDKKLLATAG-H 52 S IL S YD IR ++A TG C +T+ ++ +++++ + + + L Sbjct: 150 SSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLD 209 Query: 53 QNVRLYD------IRTTNPNPVASFEGHRGNVTSVSFQQ----DNRWMVTSSEDGTIKVW 102 V+++D +RT P+ H + F +++ E+G I W Sbjct: 210 GVVKIWDCIGGCVVRTFQVQPLEKGVLHHS--CGMDFLNPEDGSTPLVISGYENGDIYCW 267 Query: 103 DVRSPSIPR-----NYKHNAPVNEVVIHPNQGELISCDRDGNIRIW 143 + + S+ + Y H++PV + H + S +G+ +W Sbjct: 268 NSDTKSLLQLLDGSLYHHSSPVMSI--HCFGNIMCSLALNGDCCLW 311 >4BH6-A nrPDB Length = 308 Score = 136 bits (343), Expect = 9e-33, Method: Composition-based stats. Identities = 41/240 (17%), Positives = 95/240 (39%), Gaps = 14/240 (5%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTN 64 L + + ++ + C RT+ +V L N + T+G ++ R+ Sbjct: 77 LAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWNN---HVLTSGSRDHRILHRDVRM 133 Query: 65 PNPV-ASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEV 122 P+P + E H V + + + + + D + V++ S S + +H A V + Sbjct: 134 PDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAM 193 Query: 123 VIHPNQGELISCD---RDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANT 179 P++ +++ D ++IW++ + + S ++ + + + Sbjct: 194 AWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYS 253 Query: 180 KGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDD 239 K N +W+ + + P+ + HS + + LS+D + + + D T R W + D Sbjct: 254 KYNLTLWDCNS------MDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKLFDK 307 Score = 99.8 bits (247), Expect = 1e-21, Method: Composition-based stats. Identities = 47/286 (16%), Positives = 97/286 (33%), Gaps = 22/286 (7%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATA-GHQNVRLYDI 60 S +++ +I + TG + ++++ L LA + V +YD+ Sbjct: 33 STDVLAVALGKSIFLTDNNTGDVVH-LCDTENEYTSLSWIGAGSHLAVGQANGLVEIYDV 91 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY--KHNAP 118 + + GH V +S+ +N + + S D I DVR P H Sbjct: 92 --MKRKCIRTLSGHIDRVACLSW--NNHVLTSGSRDHRILHRDVRMPDPFFETIESHTQE 147 Query: 119 VNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGS-MLAAA 177 V + + +L S D + +++ ++++++ + +LA Sbjct: 148 VCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHK-AAVKAMAWSPHKRGVLATG 206 Query: 178 N--TKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLAT--CSADHTARV 233 +W + S + + I ++ S + L T + + + Sbjct: 207 GGTADRRLKIWNVNTSIKMSDIDS-------GSQICNMVWSKNTNELVTSHGYSKYNLTL 259 Query: 234 WSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDL 279 W + L GH V S D +V+ + D +R W L Sbjct: 260 WDC-NSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKL 304 Score = 93.6 bits (231), Expect = 9e-20, Method: Composition-based stats. Identities = 45/234 (19%), Positives = 88/234 (37%), Gaps = 16/234 (6%) Query: 75 RGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPNQGELIS 133 TS+S+ + +G ++++DV R H V + N L S Sbjct: 62 ENEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSW--NNHVLTS 119 Query: 134 CDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTD 193 RD I D+ + + L + LA+ +V+E + + Sbjct: 120 GSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKS- 178 Query: 194 ASHLKPVTKFRAHSTYITRILLSSDVK-HLATCS--ADHTARVWSIDDDFKLETTLDGHQ 250 P+ F H + + S + LAT AD ++W+++ K+ G Q Sbjct: 179 -----PILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQ 233 Query: 251 RWVWDCAFSADSAYLVT--ASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 + + +S ++ LVT S + + LWD ++ + + GH + + L++ Sbjct: 234 --ICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSN 285 Score = 74.3 bits (181), Expect = 7e-14, Method: Composition-based stats. Identities = 27/179 (15%), Positives = 64/179 (35%), Gaps = 10/179 (5%) Query: 124 IHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNC 183 I + ++++ +I + D H E++ SLS GS LA G Sbjct: 29 IDWSSTDVLAVALGKSIFLTDNNTGDVVHLCDTENEY--TSLSWIGAGSHLAVGQANGLV 86 Query: 184 YVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLE 243 ++++ K + H + + + L + S DH + Sbjct: 87 EIYDVMKR------KCIRTLSGHIDRVACLSW--NNHVLTSGSRDHRILHRDVRMPDPFF 138 Query: 244 TTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 T++ H + V ++ L + +D+ V +++ +++ + + H +A + Sbjct: 139 ETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSP 197 >6J6H-n nrPDB Length = 455 Score = 135 bits (341), Expect = 2e-32, Method: Composition-based stats. Identities = 53/276 (19%), Positives = 107/276 (38%), Gaps = 15/276 (5%) Query: 23 VCSRTIQHSDSQVNRLEITN-DKKLLATAGHQ-NVRLYDIRTTNPNPVASFEGHRGNVTS 80 R L+ L+ + G+ ++++D + + F+GH + + Sbjct: 153 KVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF-YHDYECLRDFQGHNKPIKA 211 Query: 81 VSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQG-ELISCDRDGN 139 + F +D + ++SS D ++K+WD + + N+ +V P E I + Sbjct: 212 LRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSK 271 Query: 140 IRIWD--LGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHL 197 I +D + ENQ Q +S+ +L DGS +++ +WE + + Sbjct: 272 ILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVP---I 328 Query: 198 KPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKL--ETTLDGHQRWVW- 254 K ++ HS + S + + S D+ +S+ +K + GH + Sbjct: 329 KQISDTAQHSMPFLNVHPSQN--YFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYG 386 Query: 255 -DCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYG 289 AFS D Y+ + S + WD +T ++ Sbjct: 387 ISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIK 422 >6E29-D nrPDB Length = 345 Score = 134 bits (338), Expect = 4e-32, Method: Composition-based stats. Identities = 59/308 (19%), Positives = 113/308 (36%), Gaps = 45/308 (14%) Query: 32 DSQVNRLEITNDKKLLATAG-HQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWM 90 + LA+ V ++D+ T GH N+TS+S+ + R++ Sbjct: 25 SGHSTCVRFNRKGDFLASGRVDGTVVIWDLET--MGVARKLRGHSKNITSLSWSRCGRYL 82 Query: 91 VTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHP-NQGELISCDRDGNIRIWDLGENQ 149 +++ + + +WD++ R + APV +HP N + + + + D+ E Sbjct: 83 LSACQGWKVILWDLQDGKRYREVRFRAPVYGAELHPWNHHQFAAALFEDQPMLVDITEPV 142 Query: 150 CTHQLTP--------EDDTSLQ-------------SLSMASDGSMLAAANTKGNCYVWEM 188 + P E D +L+ ++ + G L A TKG + Sbjct: 143 EVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGDHLLAGTTKGRLNI--- 199 Query: 189 PNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVW--------SIDDD- 239 DA + + + S IT + L+ + L + D R + +D D Sbjct: 200 ---IDARTREIIYSEKIASGIITTLRLTESGRELLVNAQDRIIRTFIVPNLSAADLDPDT 256 Query: 240 --FKLETTL-DGHQRWVWD-CAFSADSAYLVTA-SSDHYVRLWDLSTREIVRQYGGHHKG 294 LE D R W+ AFSA Y+ + ++H + +W+ +VR G + Sbjct: 257 IQLPLEHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIWERGHGSLVRMLEGPKEE 316 Query: 295 AVCVALND 302 + + Sbjct: 317 QGVIEWHP 324 Score = 45.4 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 16/58 (27%), Positives = 25/58 (43%), Gaps = 3/58 (5%) Query: 244 TTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 T GH V F+ +L + D V +WDL T + R+ GH K ++ + Sbjct: 22 TIRSGHSTCVR---FNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWS 76 Score = 35.4 bits (80), Expect = 0.031, Method: Composition-based stats. Identities = 12/71 (16%), Positives = 26/71 (36%), Gaps = 1/71 (1%) Query: 36 NRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSE 95 N + + + +A + + N LY + + V EG + + + + Sbjct: 275 NHVAFSATGEYVAASTYNNHELYIWERGHGSLVRMLEGPKEEQGVIEWHPHRALLAACGL 334 Query: 96 D-GTIKVWDVR 105 + G I +W V Sbjct: 335 ETGRINIWSVT 345 Score = 29.3 bits (64), Expect = 2.5, Method: Composition-based stats. Identities = 12/59 (20%), Positives = 24/59 (40%), Gaps = 2/59 (3%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVR--LYDI 60 + S +H + WE G R ++ + +E + LLA G + R ++ + Sbjct: 286 VAASTYNNHELYIWERGHGSLVRMLEGPKEEQGVIEWHPHRALLAACGLETGRINIWSV 344 >4BZK-B nrPDB Length = 297 Score = 134 bits (337), Expect = 5e-32, Method: Composition-based stats. Identities = 48/262 (18%), Positives = 95/262 (36%), Gaps = 30/262 (11%) Query: 44 KKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQD--NRWMVTSSEDGTIKV 101 K+L + + ++++++ + + GH G V V + + + S DG + + Sbjct: 22 KRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLI 81 Query: 102 WDVRSP---SIPRNYKHNAPVNEVVIHPN--QGELISCDRDGNIRIWDLGENQCTHQLTP 156 W + I + H+A VN V P+ L+ DG + + + EN T + Sbjct: 82 WKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIII 141 Query: 157 E-DDTSLQSLSMAS-------------DGSMLAAANTKGNCYVWEMPNHTDASHLKPVTK 202 + + S S A + +W+ ++DA + Sbjct: 142 DAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY--NSDAQTYVLEST 199 Query: 203 FRAHSTYITRILLSSD---VKHLATCSADHTARVWSIDD----DFKLETTLDGHQRWVWD 255 HS ++ + S +LA+ S D T +W+ D+ K + +W Sbjct: 200 LEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWR 259 Query: 256 CAFSADSAYLVTASSDHYVRLW 277 ++S L + D+ V LW Sbjct: 260 ASWSLSGNVLALSGGDNKVTLW 281 Score = 111 bits (278), Expect = 4e-25, Method: Composition-based stats. Identities = 60/229 (26%), Positives = 90/229 (39%), Gaps = 25/229 (10%) Query: 73 GHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS---IPRNYKHNAPVNEVVI-HPN- 127 H + + + T S D TIK+++V + I H PV V HP Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 128 QGELISCDRDGNIRIWDLGENQCTHQLTPE--DDTSLQSLSMASD--GSMLAAANTKGNC 183 L SC DG + IW EN Q+ S+ S+ A G +L A++ G Sbjct: 67 GTILASCSYDGKVLIWK-EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125 Query: 184 YVWEMP-NHTDASHLKPVTKFRAHSTYITRILLSSDVKH--------LATCSADHTARVW 234 V E N T + + +S + D +H T AD+ ++W Sbjct: 126 SVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIW 185 Query: 235 SIDDD---FKLETTLDGHQRWVWDCAFSAD---SAYLVTASSDHYVRLW 277 + D + LE+TL+GH WV D A+S +YL + S D +W Sbjct: 186 KYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW 234 Score = 101 bits (252), Expect = 4e-22, Method: Composition-based stats. Identities = 49/275 (17%), Positives = 94/275 (34%), Gaps = 30/275 (10%) Query: 5 LVSAGYDHTIRFWEA--LTGVCSRTIQHSDSQVNRLEITND--KKLLATAG-HQNVRLYD 59 L + D TI+ +E T T+ + V R++ + +LA+ V ++ Sbjct: 24 LATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWK 83 Query: 60 IRTTNPNPVASFEGHRGNVTSVSFQQD--NRWMVTSSEDGTIKVWDVR---SPSIPRNYK 114 + +A H +V SV + ++ +S DG + V + + + S Sbjct: 84 EENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDA 143 Query: 115 HNAPVNEVVIHP-------------NQGELISCDRDGNIRIWDLGENQCTHQLT---PED 158 H VN P + ++ D ++IW + T+ L Sbjct: 144 HAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGH 203 Query: 159 DTSLQSLSMASD---GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILL 215 ++ ++ + S LA+ + C +W N K + K + R Sbjct: 204 SDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDN-EQGPWKKTLLKEEKFPDVLWRASW 262 Query: 216 SSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQ 250 S LA D+ +W + + K E + HQ Sbjct: 263 SLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 297 Score = 94.0 bits (232), Expect = 7e-20, Method: Composition-based stats. Identities = 44/230 (19%), Positives = 74/230 (32%), Gaps = 30/230 (13%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQH--SDSQVNRLEITN---DKKLLATAGHQNVRL 57 IL S YD + W+ G S+ H + VN ++ LL + V + Sbjct: 68 TILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSV 127 Query: 58 YDIRTTNPNPVASFEGHRGNVTSVSFQQ-------------DNRWMVTSSEDGTIKVWDV 104 + + + H V S S+ ++R VT D +K+W Sbjct: 128 VEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKY 187 Query: 105 RSPSIPRNY-----KHNAPVNEVVIHPN---QGELISCDRDGNIRIW--DLGENQCTHQL 154 S + H+ V +V P + L S +D IW D + L Sbjct: 188 NSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTL 247 Query: 155 TPEDDTS--LQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTK 202 E+ L S + G++LA + +W+ V + Sbjct: 248 LKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLWKENLEGKWEPAGEVHQ 297 Score = 79.0 bits (193), Expect = 2e-15, Method: Composition-based stats. Identities = 37/211 (17%), Positives = 75/211 (35%), Gaps = 27/211 (12%) Query: 115 HNAPVNEVVIHPNQGELISCDRDGNIRIWDLG--ENQCTHQLTPEDDTSLQSLSMASD-G 171 HN +++ V+ L +C D I+I+++ ++ LT + + G Sbjct: 8 HNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFG 67 Query: 172 SMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSD--VKHLATCSADH 229 ++LA+ + G +W+ N + + HS + + + L S+D Sbjct: 68 TILASCSYDGKVLIWKEENGRWSQ----IAVHAVHSASVNSVQWAPHEYGPLLLVASSDG 123 Query: 230 TARVWSI-DDDFKLETTLDGHQRWVWDCAFSA-------------DSAYLVTASSDHYVR 275 V ++ +D H V +++ +S VT +D+ V+ Sbjct: 124 KVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVK 183 Query: 276 LW----DLSTREIVRQYGGHHKGAVCVALND 302 +W D T + GH VA + Sbjct: 184 IWKYNSDAQTYVLESTLEGHSDWVRDVAWSP 214 Score = 65.5 bits (158), Expect = 2e-11, Method: Composition-based stats. Identities = 28/104 (26%), Positives = 44/104 (42%), Gaps = 5/104 (4%) Query: 200 VTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDD-FKLETTLDGHQRWVWDCAF 258 V AH+ I +L K LATCS+D T +++ ++ + KL TL GH+ VW + Sbjct: 2 VVIANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDW 61 Query: 259 SA--DSAYLVTASSDHYVRLWDLSTRE--IVRQYGGHHKGAVCV 298 + L + S D V +W + + H V Sbjct: 62 AHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSV 105 Score = 55.8 bits (133), Expect = 2e-08, Method: Composition-based stats. Identities = 15/112 (13%), Positives = 35/112 (31%), Gaps = 11/112 (9%) Query: 2 SVILVSAGYDHTIRFW----EALTGVCSRTIQHSDSQVNRLEITN----DKKLLATAGHQ 53 S V+ G D+ ++ W +A T V T++ V + + L + + + Sbjct: 170 SRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDR 229 Query: 54 NVRLYDIRTTNPNPVASFEGHRGN---VTSVSFQQDNRWMVTSSEDGTIKVW 102 ++ + + S+ + S D + +W Sbjct: 230 TCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 30.8 bits (68), Expect = 0.68, Method: Composition-based stats. Identities = 13/64 (20%), Positives = 23/64 (35%), Gaps = 6/64 (9%) Query: 1 MSVILVSAGYDHTIRFW--EALTGVCSRTIQHSDSQ---VNRLEITNDKKLLA-TAGHQN 54 + L S D T W + G +T+ + + R + +LA + G Sbjct: 218 LRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNK 277 Query: 55 VRLY 58 V L+ Sbjct: 278 VTLW 281 >5OQL-J nrPDB Length = 912 Score = 132 bits (331), Expect = 3e-31, Method: Composition-based stats. Identities = 62/370 (16%), Positives = 120/370 (32%), Gaps = 70/370 (18%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEI--------------------- 40 S +L + D I+ W+ + G + T+ V+ L Sbjct: 123 STLLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHFFEIAVTAESQSSNKKPKKGSR 182 Query: 41 ---TNDKKLLAT-------AGHQNVRLYDIRTTNPNPV-----ASFEGHRGNVTSVSFQQ 85 +D +A+ +R++D+ PV E H NV +++ Sbjct: 183 KGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSP 242 Query: 86 DNRWMVTSSEDGTIKVWDVRSPSIPRN--YKHNAPVNEVVIHPNQGELISCDRDGNIRIW 143 + +++ S D T+ +W R +H + V + S G +RIW Sbjct: 243 EQHALLSGSRDKTMTLWLWRDGIWQGTPMLRHEL-LESVGFLNEGKWMYSAGTSGVLRIW 301 Query: 144 DLGENQCTHQL---TPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASH---- 196 D + + E + L ++S+ + S++ A ++ +P+ D Sbjct: 302 DTTTHHEITKKQDAKSEGEAILSAVSL-PERSLILCAQADFTLVLYRVPSPADVVSSSEG 360 Query: 197 --LKPVTKFRAHSTYITRILLS-SDVKHLATCSADHTARVWSIDDDFKL----------- 242 L+P + I + D +A + R+ S+ D Sbjct: 361 ILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGS 420 Query: 243 -----ETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDL----STREIVRQYGGHHK 293 L GH+ V ++ + S D+ RLW + ++ + GH + Sbjct: 421 YFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLE 480 Query: 294 GAVCVALNDV 303 VAL V Sbjct: 481 SVGAVALPKV 490 Score = 126 bits (316), Expect = 1e-29, Method: Composition-based stats. Identities = 61/347 (17%), Positives = 119/347 (34%), Gaps = 76/347 (21%) Query: 23 VCSRTIQHSDSQVNRLEI-TNDKKLLATAGHQ-NVRLYDIRTTN---------------P 65 R I + ++ L D+ ++A A + ++R+ ++ Sbjct: 364 EPFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFG 423 Query: 66 NPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDV-----RSPSIPRNYKHNAPVN 120 + VA +GH V S+ W+ + S+D T ++W V H V Sbjct: 424 HDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVG 483 Query: 121 EVVI-----------------HPNQGELISCDRDGNIRIWDL-----GENQCTHQLTP-E 157 V + HP LIS +D ++ D+ + T L Sbjct: 484 AVALPKVVPPANSEAFKNPLDHPPAF-LISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLA 542 Query: 158 DDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSS 217 D + +L ++ +G + A+A+ +W++ L+ R H + + + Sbjct: 543 HDKDINALDISPNGKLFASASQDKTVKIWDVEK------LEVQGILRGHKRGVWTVRFAP 596 Query: 218 DVK--------------HLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAF---SA 260 + T S D T ++W++ D+ T +GH V + S Sbjct: 597 LNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNL-SDYTCIRTFEGHSHNVLKVVWLHISR 655 Query: 261 DSAY------LVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 D + +A +D V++WD +T E H +A++ Sbjct: 656 DDSITKTKVQFASAGADTLVKVWDANTGETECTLDNHEDRLWTLAVH 702 Score = 125 bits (315), Expect = 2e-29, Method: Composition-based stats. Identities = 56/359 (15%), Positives = 116/359 (32%), Gaps = 68/359 (18%) Query: 7 SAGYDHTIRFWEALT----GVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLY---- 58 SAG +R W+ T ++ ++ + + +L + LY Sbjct: 291 SAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILCAQADFTLVLYRVPS 350 Query: 59 --DIRTTNP----NPVASFEGHRGNVTSVS-FQQDNRWMVTSSEDGTIKVWDVRSPSIPR 111 D+ +++ P G + ++ D M ++ I++ V+ Sbjct: 351 PADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYS 410 Query: 112 NY------------------KHNAPVNEVVIHPNQGELISCDRDGNIRIWDL----GENQ 149 H V + + + + S +D R+W + Sbjct: 411 EDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYT 470 Query: 150 CTHQLTPEDD----TSLQSLSMASDGS-----------MLAAANTKGNCYVWEMPNH-TD 193 C T + +L + ++ L + + ++P Sbjct: 471 CYAVFTGHLESVGAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQK 530 Query: 194 ASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWV 253 L + AH I + +S + K A+ S D T ++W ++ +++ L GH+R V Sbjct: 531 GGKLTSSLRRLAHDKDINALDISPNGKLFASASQDKTVKIWDVEK-LEVQGILRGHKRGV 589 Query: 254 WDCAFSA--------------DSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCV 298 W F+ ++T S D ++LW+LS +R + GH + V Sbjct: 590 WTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKV 648 Score = 124 bits (311), Expect = 5e-29, Method: Composition-based stats. Identities = 55/301 (18%), Positives = 108/301 (35%), Gaps = 58/301 (19%) Query: 28 IQHSDSQVNRLEITNDKKLLATAG-HQNVRLY--DIRTTNPNPVASFEGHRGNVTSVSF- 83 ++ + V L++ +A+ RL+ D + A F GH +V +V+ Sbjct: 429 LKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALP 488 Query: 84 ---------------QQDNRWMVTSSEDGTIKVWDVRSP--------SIPRNYKHNAPVN 120 ++++ S+D ++ D+ S R H+ +N Sbjct: 489 KVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDIN 548 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMAS----------- 169 + I PN S +D ++IWD+ + + L + ++ A Sbjct: 549 ALDISPNGKLFASASQDKTVKIWDVEKLEVQGILRGHK-RGVWTVRFAPLNTPVIQGEQG 607 Query: 170 --DGS-MLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILL---SSDVK--- 220 G ++ + +W + ++T + F HS + +++ S D Sbjct: 608 SVSGRGVVLTGSGDKTIKLWNLSDYT------CIRTFEGHSHNVLKVVWLHISRDDSITK 661 Query: 221 ---HLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 A+ AD +VW + + E TLD H+ +W A + + L +A SD V W Sbjct: 662 TKVQFASAGADTLVKVWDANTG-ETECTLDNHEDRLWTLAVHSKTNILASAGSDSKVTFW 720 Query: 278 D 278 Sbjct: 721 R 721 Score = 113 bits (282), Expect = 1e-25, Method: Composition-based stats. Identities = 55/353 (15%), Positives = 111/353 (31%), Gaps = 56/353 (15%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNV-RLYDIRTT 63 L+S D T+ W G+ T + + N+ K + +AG V R++D T Sbjct: 247 LLSGSRDKTMTLWLWRDGIWQGTPMLRHELLESVGFLNEGKWMYSAGTSGVLRIWDTTTH 306 Query: 64 NP-NPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS-------------I 109 + + + S + ++ + D T+ ++ V SP+ Sbjct: 307 HEITKKQDAKSEGEAILSAVSLPERSLILCAQADFTLVLYRVPSPADVVSSSEGILLEPF 366 Query: 110 PRNYKHNAPVNEVVIH-PNQGELISCDRDGNIRIWDLGENQCTHQ--------------- 153 R + + ++ P+Q + +IRI + + Q + Sbjct: 367 RRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDV 426 Query: 154 -LTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITR 212 L + + SL + G +A+ + +W + ++ F H + Sbjct: 427 ALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVDPANNSYT--CYAVFTGHLESVGA 484 Query: 213 ILLSS----------------DVKHLATCSADHTARVWSIDDDFKLETTLD------GHQ 250 + L L + S D + I + L H Sbjct: 485 VALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHD 544 Query: 251 RWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALNDV 303 + + S + +AS D V++WD+ E+ GH +G V + Sbjct: 545 KDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPL 597 Score = 108 bits (270), Expect = 3e-24, Method: Composition-based stats. Identities = 45/215 (20%), Positives = 88/215 (40%), Gaps = 35/215 (16%) Query: 4 ILVSAGYDHTIRFWEAL-----TGVCSRTIQ--HSDSQVNRLEITNDKKLLATAG-HQNV 55 L+S D ++ + G + +++ D +N L+I+ + KL A+A + V Sbjct: 509 FLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQDKTV 568 Query: 56 RLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNR--------------WMVTSSEDGTIKV 101 +++D+ GH+ V +V F N ++T S D TIK+ Sbjct: 569 KIWDVE--KLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKL 626 Query: 102 WDVRSPSIPRNY-KHNAPVNEVVI---------HPNQGELISCDRDGNIRIWDLGENQCT 151 W++ + R + H+ V +VV + + S D +++WD + Sbjct: 627 WNLSDYTCIRTFEGHSHNVLKVVWLHISRDDSITKTKVQFASAGADTLVKVWDANTGETE 686 Query: 152 HQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVW 186 L +D L +L++ S ++LA+A + W Sbjct: 687 CTLDNHEDR-LWTLAVHSKTNILASAGSDSKVTFW 720 Score = 99.8 bits (247), Expect = 1e-21, Method: Composition-based stats. Identities = 56/288 (19%), Positives = 106/288 (36%), Gaps = 22/288 (7%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKK-LLATAGHQNVRLY-- 58 + IL S ++ I E TG IQ ++ L IT L+ + +R+Y Sbjct: 32 ARILASTLGENAILT-ELNTGKRLAEIQGDGEPISTLTITPSGSHLIVCSRSLTMRIYSL 90 Query: 59 ----DIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK 114 D + P V + + H V ++ + + + T + DG IK+WD+ + Sbjct: 91 AISPDYDSVEPTLVRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIGGYVT---- 146 Query: 115 HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSML 174 H V++ I+ + + Q D+ + + L Sbjct: 147 HTVSGPSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASR--------FRL 198 Query: 175 AAANTKGNCYVWEMPNHTDAS-HLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARV 233 A G ++++ T + P K AH + + I S + L + S D T + Sbjct: 199 AWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTL 258 Query: 234 WSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLST 281 W D T + H+ + F + ++ +A + +R+WD +T Sbjct: 259 WLWRDGIWQGTPMLRHE-LLESVGFLNEGKWMYSAGTSGVLRIWDTTT 305 Score = 66.2 bits (160), Expect = 1e-11, Method: Composition-based stats. Identities = 34/215 (15%), Positives = 73/215 (33%), Gaps = 41/215 (19%) Query: 127 NQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVW 186 N +++ N + +L + ++ D + +L++ GS L + ++ Sbjct: 30 NGARILASTLGENAILTELNTGKRLAEIQG-DGEPISTLTITPSGSHLIVCSRSLTMRIY 88 Query: 187 EMPNHTDASHLKP--VTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLET 244 + D ++P V + H+T + + + LAT +AD ++W I + + Sbjct: 89 SLAISPDYDSVEPTLVRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIGGY-VTH 147 Query: 245 TLDGHQRWVWDCAF------------------------SADSAYLVT------ASSDHYV 274 T+ G V F + D+ + + + D + Sbjct: 148 TVSGPSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRI 207 Query: 275 RLWDLSTREIVRQY-------GGHHKGAVCVALND 302 R++DL R Y H C+A + Sbjct: 208 RIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSP 242 >5WYJ-BE nrPDB Length = 939 Score = 131 bits (329), Expect = 5e-31, Method: Composition-based stats. Identities = 57/305 (18%), Positives = 115/305 (37%), Gaps = 42/305 (13%) Query: 2 SVILVSAGYDHTIRFW------EALTGVCSR--------------TIQHSDSQVNRLEIT 41 S ++SA D + W +A + S+ TI+ ++ L I Sbjct: 363 SHFMLSASKDRS--LWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFPEIVALAIE 420 Query: 42 N-----DKKLLATAGHQN-VRLYDIRTTNPNPVASFEG-HRGNVTSVSFQQDNRWMVTSS 94 N + ++ + R +D+R +F+ G V SV+ Q + S Sbjct: 421 NARIGEWENIITAHKDEKFARTWDMR-NKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGS 479 Query: 95 EDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQ 153 +G+I +++++S + + YK H V + + +++SC DG + +D ++ + Sbjct: 480 SNGSITIYNMQSGILRKKYKLHKRAVTGISLDGMNRKMVSCGLDGIVGFYDFNKSTLLGK 539 Query: 154 LTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRI 213 L + D + ++ + A A + V DA + V + HS IT Sbjct: 540 L--KLDAPITAMVYHRSSDLFALALDDLSIVV------IDAVTQRVVRQLWGHSNRITAF 591 Query: 214 LLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHY 273 S + + + + S D T R W + ++ + + FS + L T Sbjct: 592 DFSPEGRWIVSASLDSTIRTWDLPTGGCIDGII--VDNVATNVKFSPNGDLLATTHVTGN 649 Query: 274 -VRLW 277 + +W Sbjct: 650 GICIW 654 Score = 90.1 bits (222), Expect = 9e-19, Method: Composition-based stats. Identities = 45/322 (13%), Positives = 110/322 (34%), Gaps = 48/322 (14%) Query: 3 VILVSAGYDHTIR--FWE-----------ALTGVCSRTIQHSDSQVNRLEI--TNDKKLL 47 I+V++G D++++ ++ R+ + + + +L Sbjct: 308 PIIVTSGGDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPSYIAFADSQSHFML 367 Query: 48 ATAGHQNVRLYDIRTTNPNPVASFEGHRG----------------NVTSVSF--QQDNRW 89 + + +++ + +R + S H+ + +++ + W Sbjct: 368 SASKDRSLWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFPEIVALAIENARIGEW 427 Query: 90 --MVTSSED-GTIKVWDVRSPSIPR---NYKHNAPVNEVVIHPNQGELISCDRDGNIRIW 143 ++T+ +D + WD+R+ + R + + V V + +G+I I+ Sbjct: 428 ENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSITIY 487 Query: 144 DLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKF 203 ++ + ++ +S+ + + G ++ T LK Sbjct: 488 NMQSGILRKKYKLHK-RAVTGISLDGMNRKMVSCGLDGIVGFYDFNKSTLLGKLKL---- 542 Query: 204 RAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSA 263 IT ++ A D + V ++ L GH + FS + Sbjct: 543 ---DAPITAMVYHRSSDLFALALDDLSIVVIDAVTQ-RVVRQLWGHSNRITAFDFSPEGR 598 Query: 264 YLVTASSDHYVRLWDLSTREIV 285 ++V+AS D +R WDL T + Sbjct: 599 WIVSASLDSTIRTWDLPTGGCI 620 Score = 77.8 bits (190), Expect = 6e-15, Method: Composition-based stats. Identities = 35/172 (20%), Positives = 63/172 (36%), Gaps = 3/172 (1%) Query: 1 MSVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDI 60 M+ +VS G D + F++ ++ D+ + + L A A + + I Sbjct: 513 MNRKMVSCGLDGIVGFYDFNKSTLLGKLK-LDAPITAMVYHRSSDLFALALDD-LSIVVI 570 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVN 120 V GH +T+ F + RW+V++S D TI+ WD+ + + Sbjct: 571 DAVTQRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTGGCIDGIIVDNVAT 630 Query: 121 EVVIHPNQGELISC-DRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDG 171 V PN L + I IW T D++ +++ S Sbjct: 631 NVKFSPNGDLLATTHVTGNGICIWTNRAQFKTVSTRTIDESEFARMALPSTS 682 Score = 74.0 bits (180), Expect = 7e-14, Method: Composition-based stats. Identities = 51/344 (14%), Positives = 116/344 (33%), Gaps = 52/344 (15%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQH----SDSQVNRLEITNDKKLLATAGHQN--- 54 S L + F++ +++ S V + N + ++ T+G N Sbjct: 261 SSHLSVGTSSGDLIFYDLDRRSRIHVLKNIHRESYGGVTQATFLNGQPIIVTSGGDNSLK 320 Query: 55 VRLYDIRTTN---------PNPVASFEGHRGNVTSVSFQQD-NRWMVTSSEDGTIKVWDV 104 ++D + P + S GH + ++F + +M+++S+D ++ + + Sbjct: 321 EYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPSYIAFADSQSHFMLSASKDRSLWSFSL 380 Query: 105 RSPSIPRNYK---HNA---------------------PVNEVVIHPNQGELISCDRDGNI 140 R + + H + I + + + + Sbjct: 381 RKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFPEIVALAIENARIGEWENIITAHKDEKFA 440 Query: 141 RIWDLGENQCTH-QLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKP 199 R WD+ + DD ++S++M+ G+ ++ G+ ++ M + Sbjct: 441 RTWDMRNKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSITIYNMQSGILRK---- 496 Query: 200 VTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKL-ETTLDGHQRWVWDCAF 258 K++ H +T I L + + +C D + + L + LD + + Sbjct: 497 --KYKLHKRAVTGISLDGMNRKMVSCGLDGIVGFYDFNKSTLLGKLKLDA---PITAMVY 551 Query: 259 SADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 S A D + + D T+ +VRQ GH + Sbjct: 552 HRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSP 595 Score = 68.6 bits (166), Expect = 4e-12, Method: Composition-based stats. Identities = 36/325 (11%), Positives = 96/325 (29%), Gaps = 38/325 (11%) Query: 14 IRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEG 73 + + TG T Q+ E ++A + + + + Sbjct: 188 VLLFNVRTGKLVFTSNEFPDQITTAEPAPVLDIIALGTVTGEVIM-FNMRKGKRIRTIKI 246 Query: 74 HRGNVTSVSFQQDNR-WMVTSSEDGTIKVWDVRSPSIPRNYK--HN---APVNEVVIHPN 127 + ++S+SF+ D + + G + +D+ S K H V + Sbjct: 247 PQSRISSLSFRTDGSSHLSVGTSSGDLIFYDLDRRSRIHVLKNIHRESYGGVTQATFLNG 306 Query: 128 QGELISCDRDGNIRIWDL-------------GENQCTHQLTPEDDTSLQSLSMASDGSML 174 Q +++ D +++ + + S + Sbjct: 307 QPIIVTSGGDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPSYIAFADSQSHFM 366 Query: 175 AAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSD--------------VK 220 +A+ + + + + + + + + + S + Sbjct: 367 LSASKDRSLWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFPEIVALAIENARIGE 426 Query: 221 H--LATCSAD-HTARVWSIDDDFKLETTLDG-HQRWVWDCAFSADSAYLVTASSDHYVRL 276 + T D AR W + + T D +V A S + SS+ + + Sbjct: 427 WENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSITI 486 Query: 277 WDLSTREIVRQYGGHHKGAVCVALN 301 +++ + + ++Y H + ++L+ Sbjct: 487 YNMQSGILRKKYKLHKRAVTGISLD 511 Score = 63.6 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 44/327 (13%), Positives = 108/327 (33%), Gaps = 46/327 (14%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKK--LLATAGHQNVRLYDIR 61 I+ + + G RTI+ S+++ L D L ++ YD+ Sbjct: 220 IIALGTVTGEVIMFNMRKGKRIRTIKIPQSRISSLSFRTDGSSHLSVGTSSGDLIFYDLD 279 Query: 62 TTNPNPVASFEGHR--GNVTSVSFQQDNRWMVTSSEDGTIK--VWD--VRSPS------- 108 + V G VT +F +VTS D ++K V+D + S Sbjct: 280 RRSRIHVLKNIHRESYGGVTQATFLNGQPIIVTSGGDNSLKEYVFDPSLSQGSGDVVVQP 339 Query: 109 ---IPRNYKHNAPVNEVVIH-PNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDT---- 160 + H+ P + + ++S +D ++ + L ++ + +++ Sbjct: 340 PRYLRSRGGHSQPPSYIAFADSQSHFMLSASKDRSLWSFSLRKDAQSQEMSQRLHKKQDG 399 Query: 161 ------------------SLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTK 202 ++++ + +++ A + W+M N T Sbjct: 400 GRVGGSTIKSKFPEIVALAIENARIGEWENIITAHKDEKFARTWDMRNKRVGRW----TF 455 Query: 203 FRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADS 262 ++ + +S S++ + ++++ L H+R V + + Sbjct: 456 DTTDDGFVKSVAMSQCGNFGFIGSSNGSITIYNMQSGI-LRKKYKLHKRAVTGISLDGMN 514 Query: 263 AYLVTASSDHYVRLWDLSTREIVRQYG 289 +V+ D V +D + ++ + Sbjct: 515 RKMVSCGLDGIVGFYDFNKSTLLGKLK 541 >5Y1U-A nrPDB Length = 456 Score = 130 bits (328), Expect = 6e-31, Method: Composition-based stats. Identities = 49/288 (17%), Positives = 102/288 (35%), Gaps = 43/288 (14%) Query: 30 HSDSQVNRLEITNDKKLLATAG--HQNVRLYDIR--------TTNPNPVASFEGHRGNVT 79 + + +VNR + +V ++D + NP GH+ Sbjct: 153 NHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGY 212 Query: 80 SVSFQQD-NRWMVTSSEDGTIKVWDVR----SPSIPRN----YKHNAPVNEVVIH-PNQG 129 +S+ + + ++++S+D TI +WD+ + H A V +V H ++ Sbjct: 213 GLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 272 Query: 130 ELISCDRDGNIRIWDLGENQCTHQLTP--EDDTSLQSLSMAS-DGSMLAAANTKGNCYVW 186 S D + IWD N + + LS +LA + +W Sbjct: 273 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 332 Query: 187 EMPNHTDASHLKPVTKFRAHSTYITRILLSS-DVKHLATCSADHTARVWSIDD------- 238 ++ N + F +H I ++ S + LA+ D VW + Sbjct: 333 DLRNLK-----LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSP 387 Query: 239 ------DFKLETTLDGHQRWVWDCAFSADSAY-LVTASSDHYVRLWDL 279 +L GH + D +++ + + + + S D+ +++W + Sbjct: 388 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 435 Score = 117 bits (293), Expect = 6e-27, Method: Composition-based stats. Identities = 48/278 (17%), Positives = 96/278 (34%), Gaps = 39/278 (14%) Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMV-TSSEDGTIKVWDVR--------SPSI-- 109 + + H G V + N ++ T + + V+D S Sbjct: 141 SVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNP 200 Query: 110 -PRNYKHNAPVNEVVIHPN-QGELISCDRDGNIRIWDL----GENQCT--HQLTPEDDTS 161 R H + +PN G L+S D I +WD+ E + + Sbjct: 201 DLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAV 260 Query: 162 LQSLSMAS-DGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVK 220 ++ +S S+ + +W+ ++ KP AH+ + + + + Sbjct: 261 VEDVSWHLLHESLFGSVADDQKLMIWDTRSNN---TSKPSHSVDAHTAEVNCLSFNPYSE 317 Query: 221 H-LATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSA-DSAYLVTASSDHYVRLWD 278 LAT SAD T +W + + + + H+ ++ +S + L ++ +D + +WD Sbjct: 318 FILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 377 Query: 279 LST--------------REIVRQYGGHHKGAVCVALND 302 LS E++ +GGH + N Sbjct: 378 LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNP 415 Score = 114 bits (286), Expect = 4e-26, Method: Composition-based stats. Identities = 42/220 (19%), Positives = 80/220 (36%), Gaps = 28/220 (12%) Query: 1 MSVILVSAGYDHTIRFWEALT-------GVCSRTIQHSDSQVNRLEIT--NDKKLLATAG 51 +S L+SA DHTI W+ + V + ++ + A Sbjct: 220 LSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVAD 279 Query: 52 HQNVRLYDIRTTNP-NPVASFEGHRGNVTSVSFQQDNRWM-VTSSEDGTIKVWDVRSPSI 109 Q + ++D R+ N P S + H V +SF + ++ T S D T+ +WD+R+ + Sbjct: 280 DQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKL 339 Query: 110 PRN--YKHNAPVNEVVIHP-NQGELISCDRDGNIRIWDLGENQ-------------CTHQ 153 + H + +V P N+ L S D + +WDL + Sbjct: 340 KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLF 399 Query: 154 LTPEDDTSLQSLSMASDGS-MLAAANTKGNCYVWEMPNHT 192 + + S + ++ + + VW+M + Sbjct: 400 IHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENI 439 >3CFV-B nrPDB Length = 414 Score = 129 bits (323), Expect = 2e-30, Method: Composition-based stats. Identities = 49/288 (17%), Positives = 105/288 (36%), Gaps = 43/288 (14%) Query: 30 HSDSQVNRLEITNDKKLLATAG--HQNVRLYDIR--------TTNPNPVASFEGHRGNVT 79 + + +VNR + +V ++D + NP GH+ Sbjct: 124 NHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGY 183 Query: 80 SVSFQQD-NRWMVTSSEDGTIKVWDVRSP--------SIPRNYKHNAPVNEVVIH-PNQG 129 +S+ + + ++++S+D T+ +WD+ + + H+A V +V H ++ Sbjct: 184 GLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHES 243 Query: 130 ELISCDRDGNIRIWDLGENQCTH--QLTPEDDTSLQSLSMAS-DGSMLAAANTKGNCYVW 186 S D + IWD N + L + LS +LA + +W Sbjct: 244 LFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 303 Query: 187 EMPNHTDASHLKPVTKFRAHSTYITRILLSS-DVKHLATCSADHTARVWSIDD------- 238 ++ N + F +H I ++ S + LA+ D VW + Sbjct: 304 DLRNLK-----LKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSA 358 Query: 239 ------DFKLETTLDGHQRWVWDCAFSADSAY-LVTASSDHYVRLWDL 279 +L GH + D +++ + + + + S D+ +++W + Sbjct: 359 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQM 406 Score = 112 bits (279), Expect = 3e-25, Method: Composition-based stats. Identities = 46/265 (17%), Positives = 92/265 (34%), Gaps = 39/265 (14%) Query: 74 HRGNVTSVSFQQDNRWMV-TSSEDGTIKVWDVR--------SPSI---PRNYKHNAPVNE 121 H G V + N ++ T + + V+D S R H Sbjct: 125 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYG 184 Query: 122 VVIHPN-QGELISCDRDGNIRIWDLGEN------QCTHQLTPEDDTSLQSLSMAS-DGSM 173 + + N G L+S D + +WD+ + ++ ++ S+ Sbjct: 185 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 244 Query: 174 LAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKH-LATCSADHTAR 232 + +W+ ++T KP AH+ + + + + LAT SAD T Sbjct: 245 FGSVADDQKLMIWDTRSNT---TSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVA 301 Query: 233 VWSIDDDFKLETTLDGHQRWVWDCAFSA-DSAYLVTASSDHYVRLWDLST---------- 281 +W + + T + H+ ++ +S + L ++ +D + +WDLS Sbjct: 302 LWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDA 361 Query: 282 ----REIVRQYGGHHKGAVCVALND 302 E++ +GGH + N Sbjct: 362 EDGPPELLFIHGGHTAKISDFSWNP 386 Score = 111 bits (277), Expect = 4e-25, Method: Composition-based stats. Identities = 38/220 (17%), Positives = 80/220 (36%), Gaps = 28/220 (12%) Query: 1 MSVILVSAGYDHTIRFWEALTG-------VCSRTIQHSDSQVNRLEIT--NDKKLLATAG 51 +S L+SA DHT+ W+ G + V + ++ + A Sbjct: 191 LSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVAD 250 Query: 52 HQNVRLYDIRTTNPNPVASF-EGHRGNVTSVSFQQDNRWM-VTSSEDGTIKVWDVRSPSI 109 Q + ++D R+ + + + H V +SF + ++ T S D T+ +WD+R+ + Sbjct: 251 DQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKL 310 Query: 110 PRNY--KHNAPVNEVVIHP-NQGELISCDRDGNIRIWDLGENQ-------------CTHQ 153 + H + +V P N+ L S D + +WDL + Sbjct: 311 KLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLF 370 Query: 154 LTPEDDTSLQSLSMASDGS-MLAAANTKGNCYVWEMPNHT 192 + + S + ++ + + +W+M + Sbjct: 371 IHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENI 410 >4A11-B nrPDB Length = 408 Score = 128 bits (322), Expect = 3e-30, Method: Composition-based stats. Identities = 52/243 (21%), Positives = 91/243 (37%), Gaps = 39/243 (16%) Query: 74 HRGNVTSVSFQQ-DNRWMVTSSEDGTIKVWDVRSPSIPRNYK--------------HNAP 118 H G + ++ + + R+M++ DG I ++D+ + S Y H Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 119 VNEVVIHPNQ-GELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAA 177 V V +P+ G S D +++WD Q E+ +S S L A Sbjct: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAV 161 Query: 178 NTKG-NCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKH-LATCSADHTARVWS 235 T+G + ++ + + + H I + S + LAT SAD ++W Sbjct: 162 GTRGPKVQLCDLKSGS------CSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWD 215 Query: 236 IDDDFKLETTLD---------------GHQRWVWDCAFSADSAYLVTASSDHYVRLWDLS 280 + TLD H V F++D +L+T +D+ +RLW+ S Sbjct: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 Query: 281 TRE 283 E Sbjct: 276 NGE 278 Score = 97.8 bits (242), Expect = 5e-21, Method: Composition-based stats. Identities = 53/312 (16%), Positives = 106/312 (33%), Gaps = 44/312 (14%) Query: 3 VILVSAGYDHTIRFWEALTG----------VCSRTIQH---SDSQVNRLEITN-DKKLLA 48 ++S G D I ++ VCS H V ++ D + Sbjct: 57 RYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFT 116 Query: 49 TAG-HQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNR---WMVTSSEDGTIKVWDV 104 ++ + ++++D T V +FE V S + + + +++ D+ Sbjct: 117 SSSFDKTLKVWDTNTLQTADVFNFE---ETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDL 173 Query: 105 RSPSIPRNYK-HNAPVNEVVIHPNQGELI-SCDRDGNIRIWDLGE-NQCTHQLTPE---- 157 +S S + H + V P ++ + D +++WD+ + C L Sbjct: 174 KSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKK 233 Query: 158 ----------DDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDA--SHLKPVTKFRA 205 + + L SDG L T +W N + ++ K + Sbjct: 234 SQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKK 293 Query: 206 HSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYL 265 + SS+ + S T V+++ ++ T L GH + V C F ++ L Sbjct: 294 GLKFTVSCGCSSEFVFVPYGS---TIAVYTVYSGEQI-TMLKGHYKTVDCCVFQSNFQEL 349 Query: 266 VTASSDHYVRLW 277 + S D + W Sbjct: 350 YSGSRDCNILAW 361 Score = 45.8 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 14/99 (14%), Positives = 38/99 (38%), Gaps = 14/99 (14%) Query: 204 RAHSTYITRILLSS-DVKHLATCSADHTARVWSIDDDFKLETT------------LDGHQ 250 R H I + + + +++ + +D ++ +++ + D H+ Sbjct: 40 RIHGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHR 99 Query: 251 RWVWDCAFSADSAYLVTASS-DHYVRLWDLSTREIVRQY 288 V + + T+SS D +++WD +T + + Sbjct: 100 YSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVF 138 >4XYI-A nrPDB Length = 430 Score = 128 bits (322), Expect = 3e-30, Method: Composition-based stats. Identities = 51/288 (17%), Positives = 108/288 (37%), Gaps = 46/288 (15%) Query: 30 HSDSQVNRLEITNDK-KLLATAG-HQNVRLYDIRTTNPNPVAS------FEGHRGNVTSV 81 H + VN+ ++AT G + N ++D+ P+ H + Sbjct: 129 HHEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGL 188 Query: 82 SFQ--QDNRWMVTSSEDGTIKVWDVRSPSIPRN-----------YKHNAPVNEVVIH-PN 127 + Q+ + T +ED +I VWD++ S+ ++H A VN++ H + Sbjct: 189 GWNFIQEGT-LATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQH 247 Query: 128 QGELISCDRDGNIRIWD--LGENQCTHQLTPEDDTSLQSLSMAS-DGSMLAAANTKGNCY 184 + L S D ++I D L + Q + + ++ + +LA A+ Sbjct: 248 EALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVA 307 Query: 185 VWEMPNHTDASHLKPVTKFRAHSTYITRILLSS-DVKHLATCSADHTARVWSIDD----- 238 +W++ + + H + + S D L T S D VW + Sbjct: 308 LWDLRRLN-----QRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQ 362 Query: 239 --------DFKLETTLDGHQRWVWDCAFSADSAYLVTA-SSDHYVRLW 277 +L GH V D +++ ++ +++ + + D+ +++W Sbjct: 363 TVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIW 410 Score = 99.0 bits (245), Expect = 2e-21, Method: Composition-based stats. Identities = 39/227 (17%), Positives = 77/227 (33%), Gaps = 31/227 (13%) Query: 5 LVSAGYDHTIRFWEALTGV----------CSRTIQHSDSQVNRLEITNDKK-LLATAGHQ 53 L + D +I W+ + VN L+ + LL + Sbjct: 198 LATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEALLTSVSDD 257 Query: 54 -NVRLYDIR-TTNPNPVASFEGHRGNVTSVSFQQDNRW-MVTSSEDGTIKVWDVR--SPS 108 ++++D R ++ + + H V V+F N + + T+S D T+ +WD+R + Sbjct: 258 CTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLNQR 317 Query: 109 IPRNYKHNAPVNEVVIHPN-QGELISCDRDGNIRIWDLGENQCTHQ-------------L 154 + H V V P+ + L++ D + +WDL + + Sbjct: 318 LHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFM 377 Query: 155 TPEDDTSLQSLSMASDGS-MLAAANTKGNCYVWEMPNHTDASHLKPV 200 + LS + +LA+ +W AS + Sbjct: 378 HGGHTNRVSDLSWNPNNKWVLASLADDNILQIWSPSKVIWASDSLKI 424 Score = 70.9 bits (172), Expect = 6e-13, Method: Composition-based stats. Identities = 23/119 (19%), Positives = 54/119 (45%), Gaps = 16/119 (13%) Query: 4 ILVSAGYDHTIRFWEALT-GVCSRTIQHSDSQVNRLEITN-DKKLLATAG-HQNVRLYDI 60 +L +A DHT+ W+ T++ + +V ++ + D+ +L T+ + V ++D+ Sbjct: 296 LLATASADHTVALWDLRRLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDL 355 Query: 61 ------------RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTS-SEDGTIKVWDVRS 106 P + GH V+ +S+ +N+W++ S ++D +++W Sbjct: 356 SKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIWSPSK 414 Score = 41.6 bits (96), Expect = 5e-04, Method: Composition-based stats. Identities = 12/73 (16%), Positives = 27/73 (36%), Gaps = 16/73 (21%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQ--------------HSDSQVNRLEITNDKKL-L 47 ILV++ D + W+ +T++ ++V+ L + K L Sbjct: 339 PILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVL 398 Query: 48 ATAGHQNVR-LYD 59 A+ N+ ++ Sbjct: 399 ASLADDNILQIWS 411 >3C9C-A nrPDB Length = 432 Score = 128 bits (322), Expect = 3e-30, Method: Composition-based stats. Identities = 51/288 (17%), Positives = 105/288 (36%), Gaps = 43/288 (14%) Query: 30 HSDSQVNRLEITNDKKLLATAG--HQNVRLYDIR--------TTNPNPVASFEGHRGNVT 79 + + +VNR + +V ++D + P GH+ Sbjct: 128 NHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGY 187 Query: 80 SVSFQQD-NRWMVTSSEDGTIKVWDVR-SPSIPRNY-------KHNAPVNEVVIH-PNQG 129 +S+ + N +++++S+D TI +WD+ +P R H A V +V H ++ Sbjct: 188 GLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHES 247 Query: 130 ELISCDRDGNIRIWDLGENQCTHQLTP--EDDTSLQSLSMAS-DGSMLAAANTKGNCYVW 186 S D + IWD N + + LS +LA + +W Sbjct: 248 LFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 307 Query: 187 EMPNHTDASHLKPVTKFRAHSTYITRILLSS-DVKHLATCSADHTARVWSIDD------- 238 ++ N + F +H I ++ S + LA+ D VW + Sbjct: 308 DLRNLK-----LKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQST 362 Query: 239 ------DFKLETTLDGHQRWVWDCAFSADSAYLV-TASSDHYVRLWDL 279 +L GH + D +++ + +++ + S D+ +++W + Sbjct: 363 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 410 Score = 119 bits (297), Expect = 2e-27, Method: Composition-based stats. Identities = 48/271 (17%), Positives = 94/271 (34%), Gaps = 39/271 (14%) Query: 68 VASFEGHRGNVTSVSFQQDNRW-MVTSSEDGTIKVWDVR--------SPSI---PRNYKH 115 + H G V + N + T + + V+D S R H Sbjct: 123 IEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGH 182 Query: 116 NAPVNEVVIHPN-QGELISCDRDGNIRIWDLGENQCTHQ------LTPEDDTSLQSLSMA 168 + +PN G L+S D I +WD+ H+ + ++ ++ Sbjct: 183 QKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWH 242 Query: 169 S-DGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKH-LATCS 226 S+ + +W+ N+ KP AH+ + + + + LAT S Sbjct: 243 LLHESLFGSVADDQKLMIWDTRNNN---TSKPSHTVDAHTAEVNCLSFNPYSEFILATGS 299 Query: 227 ADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSA-DSAYLVTASSDHYVRLWDLST---- 281 AD T +W + + + + H+ ++ +S + L ++ +D + +WDLS Sbjct: 300 ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEE 359 Query: 282 ----------REIVRQYGGHHKGAVCVALND 302 E++ +GGH + N Sbjct: 360 QSTEDAEDGPPELLFIHGGHTAKISDFSWNP 390 Score = 116 bits (290), Expect = 1e-26, Method: Composition-based stats. Identities = 43/216 (19%), Positives = 80/216 (37%), Gaps = 28/216 (12%) Query: 4 ILVSAGYDHTIRFWEA-LTGVCSRTIQ------HSDSQVNRLEIT--NDKKLLATAGHQN 54 L+SA DHTI W+ T R I + V + ++ + A Q Sbjct: 198 YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESLFGSVADDQK 257 Query: 55 VRLYDIRTTNP-NPVASFEGHRGNVTSVSFQQDNRWM-VTSSEDGTIKVWDVRSPSIPRN 112 + ++D R N P + + H V +SF + ++ T S D T+ +WD+R+ + + Sbjct: 258 LMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 317 Query: 113 --YKHNAPVNEVVIHP-NQGELISCDRDGNIRIWDLGENQ-------------CTHQLTP 156 H + +V P N+ L S D + +WDL + + Sbjct: 318 SFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHG 377 Query: 157 EDDTSLQSLSMASDGS-MLAAANTKGNCYVWEMPNH 191 + S + ++ + + VW+M + Sbjct: 378 GHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAEN 413 Score = 41.6 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 17/101 (16%), Positives = 33/101 (32%), Gaps = 30/101 (29%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRT 62 IL S+G D + W+ ++ + D Sbjct: 337 TILASSGTDRRLHVWDLSKIGEEQSTE-----------------------------DAED 367 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMV-TSSEDGTIKVW 102 P + GH ++ S+ + W++ + SED ++VW Sbjct: 368 GPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 408 >5OQL-L nrPDB Length = 557 Score = 125 bits (315), Expect = 1e-29, Method: Composition-based stats. Identities = 53/265 (20%), Positives = 99/265 (37%), Gaps = 19/265 (7%) Query: 30 HSDSQVNR--LEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDN 87 + + V+ + L A V ++ IR P+ + + D Sbjct: 54 GTTALVSSSLVAAAKTNDLFAVTAGPRVEIFSIR--KREPLKTIGRFDSEAHCGEIRPDG 111 Query: 88 RWMVTSSEDGTIKVWDVRSPSIPRNYK----HNAPVNEVVIHPNQ-GELISCDRDGNIRI 142 R +V + G ++V+DV + K H PV P + L+SC D +R+ Sbjct: 112 RVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRL 171 Query: 143 WDLGENQCTHQLTPEDDTSLQSLSM--ASDGSMLAAANTKGNCYVWEMPNHTDASHLKPV 200 WDL N T T D M +++ ++L + + VW+ A V Sbjct: 172 WDLPSNDPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGA-----V 226 Query: 201 TKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSA 260 F+ H+ I +L L S + V + L HQ+ V + ++ Sbjct: 227 MTFK-HADPIEDVLPLPSGTTLLAASG-NAISVLDLVAAKPLRLI-TNHQKTVTSLSLAS 283 Query: 261 DSAYLVTASSDHYVRLWDLSTREIV 285 +V+ S D +V++++ ++ +V Sbjct: 284 QGRRVVSGSLDGHVKVFETTSWNVV 308 Score = 110 bits (274), Expect = 9e-25, Method: Composition-based stats. Identities = 52/240 (21%), Positives = 99/240 (41%), Gaps = 15/240 (6%) Query: 3 VILVSAGYDHTIRFWEALTG---VCSRTIQHSDSQVNRLEITND--KKLLATAGHQNVRL 57 +LV+ ++ ++ G V +T V + + L++ + + VRL Sbjct: 112 RVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRL 171 Query: 58 YDIRTTNPNPVASFEGHRGNVTSVSFQQ---DNRWMVTSSEDGTIKVWDVRS-PSIPRNY 113 +D+ + +P F GH V +F ++ +V+ S D T++VWD R+ + Sbjct: 172 WDLPSN--DPTRLFTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVMTF 229 Query: 114 KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSM 173 KH P+ +V+ P+ L++ I + DL + +T T + SLS+AS G Sbjct: 230 KHADPIEDVLPLPSGTTLLAASG-NAISVLDLVAAKPLRLITNHQKT-VTSLSLASQGRR 287 Query: 174 LAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARV 233 + + + G+ V+E + + K S + S D +HLA + Sbjct: 288 VVSGSLDGHVKVFETTSWNVVAGAK--YPSPILSLSVITAGASHDDRHLAVGMQSGVLSI 345 Score = 85.1 bits (209), Expect = 3e-17, Method: Composition-based stats. Identities = 36/124 (29%), Positives = 65/124 (52%), Gaps = 4/124 (3%) Query: 2 SVILVSAGYDHTIRFWEA-LTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDI 60 S +LVS YD T+R W+A G T +H+D + L + + LLA +G+ + + D+ Sbjct: 202 SNLLVSGSYDETVRVWDARAPGGAVMTFKHADPIEDVLPLPSGTTLLAASGN-AISVLDL 260 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVN 120 P + + H+ VTS+S R +V+ S DG +KV++ S ++ K+ +P+ Sbjct: 261 VAAKPLRLIT--NHQKTVTSLSLASQGRRVVSGSLDGHVKVFETTSWNVVAGAKYPSPIL 318 Query: 121 EVVI 124 + + Sbjct: 319 SLSV 322 Score = 71.3 bits (173), Expect = 6e-13, Method: Composition-based stats. Identities = 30/142 (21%), Positives = 50/142 (35%), Gaps = 9/142 (6%) Query: 162 LQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKH 221 SL A+ + L A ++ + + AH I D + Sbjct: 60 SSSLVAAAKTNDLFAVTAGPRVEIFSIRKREPLKTIGRFDS-EAHCGEIR-----PDGRV 113 Query: 222 LATCSADHTARVWSIDDDFK--LETTLDGHQRWVWDCAFSADS-AYLVTASSDHYVRLWD 278 L +V+ + + + T H++ VW +S L++ S D VRLWD Sbjct: 114 LVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWD 173 Query: 279 LSTREIVRQYGGHHKGAVCVAL 300 L + + R + GH C A Sbjct: 174 LPSNDPTRLFTGHTDYVRCGAF 195 >5CXC-A nrPDB Length = 510 Score = 125 bits (313), Expect = 3e-29, Method: Composition-based stats. Identities = 65/296 (21%), Positives = 103/296 (34%), Gaps = 48/296 (16%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQH----SDSQVNRLEITNDKKLLATAGHQNVRLY-- 58 ++SA YD +R W A V + + + + + +L + + VR++ Sbjct: 161 VLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSDRLASAGMDRTVRVWKY 220 Query: 59 ---DIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK- 114 D T P GH G+V + ++ ++T+S DG I W S P Sbjct: 221 TESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSASKASAPEPDAS 280 Query: 115 ------------------------------HNAPVNEVVIHPNQGELI-SCDRDGNIRIW 143 H AP + P + S +D +R Sbjct: 281 LLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQDHTVRTL 340 Query: 144 DLGENQCTHQLT-PEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTK 202 DL Q LT SL +L+ A S L AA T P + A+ V Sbjct: 341 DLTTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDPRASSATT--SVMT 398 Query: 203 FRAHSTYITRILLSSDVKH-LATCSADHTARVWSI---DDDFKLETTLDGHQRWVW 254 R H+ + + S + ++ L + S D T RVW + K E +L G V+ Sbjct: 399 LRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKEEGSLGGVSEPVY 454 Score = 86.3 bits (212), Expect = 1e-17, Method: Composition-based stats. Identities = 49/298 (16%), Positives = 86/298 (28%), Gaps = 85/298 (28%) Query: 83 FQQDNRWMVTSSEDGTIKVWDVRSPSIPRN-----YKHNAPVNEVVIHPNQGELISCDRD 137 Q ++++S DG +++W+ I + H A + L S D Sbjct: 154 VQPGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFL-TSDRLASAGMD 212 Query: 138 GNIRIWDLGE-NQCTHQLTP-----EDDTSLQSLSMASDGSMLAAANTKGNCYVW----- 186 +R+W E + T +L P S+ L + + A+ G W Sbjct: 213 RTVRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSASKA 272 Query: 187 -------------------EMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLA-TCS 226 + + + P+ + H+ T + + +A + S Sbjct: 273 SAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSAS 332 Query: 227 ADHTARVWSIDDDFKLET------------------------------------------ 244 DHT R + + T Sbjct: 333 QDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDPRASSA 392 Query: 245 -----TLDGHQRWVWDCAFSADSAY-LVTASSDHYVRLWDLSTREIVRQYGGHHKGAV 296 TL GH V + S ++ Y LV+ S D R+WDL + + G G Sbjct: 393 TTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKEEGSLGGVS 450 Score = 40.4 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 19/97 (19%), Positives = 36/97 (37%), Gaps = 16/97 (16%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTN 64 LVS +D T R W+ + + + S V+ +++ + + Sbjct: 419 LVSGSHDGTCRVWDLRSVRPATKEEGSLGGVSEPVYVIERES-----------WASKGKK 467 Query: 65 PNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKV 101 PVA G V SV + + + + ED ++V Sbjct: 468 KRPVA---GDGCKVFSVVWDKLG--IFSGGEDKKVQV 499 Score = 30.0 bits (66), Expect = 1.2, Method: Composition-based stats. Identities = 9/46 (19%), Positives = 18/46 (39%), Gaps = 6/46 (13%) Query: 260 ADSAYLVTASSDHYVRLWDLSTREIVRQ-----YGGHHKGAVCVAL 300 +++AS D +R+W+ S ++ +GGH Sbjct: 156 PGQERVLSASYDGLLRIWNAS-GSVIATSPSGSHGGHTASIKAAKF 200 >6BX3-B nrPDB Length = 412 Score = 124 bits (310), Expect = 6e-29, Method: Composition-based stats. Identities = 58/292 (19%), Positives = 118/292 (40%), Gaps = 34/292 (11%) Query: 37 RLEITNDKKLLA-TAGHQNVRLYDIRTTNPNPV--ASFEGHRGNVTSVSFQQDNRWMVTS 93 L+ + LA + + +YD+ T P V H +TS+++ D R ++TS Sbjct: 30 CLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTS 89 Query: 94 SEDGTIKVWDVRSPSIP-RNYKHNAPVNEVVIHPNQGELISCD--RDGNIRIWDLGENQC 150 S D +IK+WD+ PS P + + ++P+ + L + + + D + Sbjct: 90 SRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPV 149 Query: 151 THQL----------TPEDDTSLQSLSMASDGSMLAAANTKGNCYVW-EMPNHTDASHLKP 199 L TP+ L +++ +KG W + + Sbjct: 150 ASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKG----WLDFYKFHSLYQTEC 205 Query: 200 VTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI---DDDFKLETTLD-GHQRWVWD 255 + + S+ I +++S + + LA +D T R + I D++ +E TL+ +Q + Sbjct: 206 IHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINK 265 Query: 256 CAF------SADSAYLVT---ASSDHYVRLWDLSTREIVRQYGGHHKGAVCV 298 + + + YLV SS H + +W+ ++ +VR G + + + Sbjct: 266 LQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDI 317 Score = 70.1 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 28/124 (22%), Positives = 43/124 (34%), Gaps = 3/124 (2%) Query: 145 LGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFR 204 L E+ T E+ + L + G LA G +++M P Sbjct: 11 LKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFR--PICVPGNMLG 68 Query: 205 AHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAY 264 AH IT I S D + L T S D + ++W + K + +W C + Sbjct: 69 AHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIR-FDSPIWGCQWLDAKRR 127 Query: 265 LVTA 268 L A Sbjct: 128 LCVA 131 >4U1E-I nrPDB Length = 347 Score = 124 bits (310), Expect = 7e-29, Method: Composition-based stats. Identities = 41/233 (17%), Positives = 95/233 (40%), Gaps = 15/233 (6%) Query: 70 SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW-DVRSPSIPRNYKHNAPVNEVVIHPNQ 128 GH +T V + ++ + + S+D + VW + + H + + + Sbjct: 5 KLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVDCFT 64 Query: 129 GELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK-----GNC 183 ++ D +I++WD+ QC + ++ + + G+ A G+ Sbjct: 65 KYCVTGSADYSIKLWDVSNGQCVATW--KSPVPVKRVEFSPCGNYFLAILDNVMKNPGSI 122 Query: 184 YVWEMPNHTDASHLKPVTKFRAHS-------TYITRILLSSDVKHLATCSADHTARVWSI 236 ++E+ + L V++ H T S+ K++ D + + Sbjct: 123 NIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKYDV 182 Query: 237 DDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYG 289 ++++ ++D H++ + D FS D Y +T+S D L D+ST +++++Y Sbjct: 183 SNNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLVDVSTLQVLKKYE 235 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 48/321 (14%), Positives = 104/321 (32%), Gaps = 79/321 (24%) Query: 28 IQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQD 86 + + + +++ + LL + + ++ + N + + +GH G + S+ Sbjct: 6 LTGHERPLTQVKYNKEGDLLFSCSKDSSASVW--YSLNGERLGTLDGHTGTIWSIDVDCF 63 Query: 87 NRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRD-----GNIR 141 ++ VT S D +IK+WDV + +K PV V P ++ + G+I Sbjct: 64 TKYCVTGSADYSIKLWDVSNGQCVATWKSPVPVKRVEFSPCGNYFLAILDNVMKNPGSIN 123 Query: 142 IWDLGENQCTHQLTPEDDTSLQSLS------------MASDGSMLAAANTKGNCYVWEMP 189 I+++ + TH+LT + + + ++ G + A + G +++ Sbjct: 124 IYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKYDVS 183 Query: 190 NHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSAD-----------HTARVW---- 234 N + + V H I+ + S D+ + T S D + + Sbjct: 184 N-----NYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLVDVSTLQVLKKYETDC 238 Query: 235 -----------------------SIDDDFKLETTLD----------------GHQRWVWD 255 + E + GH + Sbjct: 239 PLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEEEIGRVQGHFGPLNT 298 Query: 256 CAFSADSAYLVTASSDHYVRL 276 A S + D ++RL Sbjct: 299 VAISPQGTSYASGGEDGFIRL 319 Score = 91.7 bits (226), Expect = 4e-19, Method: Composition-based stats. Identities = 38/262 (14%), Positives = 90/262 (34%), Gaps = 30/262 (11%) Query: 6 VSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGH------QNVRLYD 59 V+ D++I+ W+ G C T + S V R+E + ++ +Y+ Sbjct: 68 VTGSADYSIKLWDVSNGQCVATWK-SPVPVKRVEFSPCGNYFLAILDNVMKNPGSINIYE 126 Query: 60 IRTTN---------PNPVASFEGHRG-NVTSVS-FQQDNRWMVTSSEDGTIKVWDVRS-- 106 I + P+ H G + +V+ + ++++ +DG I +DV + Sbjct: 127 IERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKYDVSNNY 186 Query: 107 PSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLS 166 + H ++++ P+ I+ RD N + D+ Q + E D L + Sbjct: 187 EYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLVDVSTLQVLKK--YETDCPLNTAV 244 Query: 167 MASDGSMLAAANTK--GNCYVWEMPNHTDASHL------KPVTKFRAHSTYITRILLSSD 218 + + + + + + + + + H + + +S Sbjct: 245 ITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEEEIGRVQGHFGPLNTVAISPQ 304 Query: 219 VKHLATCSADHTARVWSIDDDF 240 A+ D R+ + + Sbjct: 305 GTSYASGGEDGFIRLHHFEKSY 326 Score = 48.5 bits (114), Expect = 3e-06, Method: Composition-based stats. Identities = 11/57 (19%), Positives = 22/57 (38%) Query: 245 TLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 L GH+R + ++ + L + S D +W E + GH + ++ Sbjct: 5 KLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGTIWSIDVD 61 Score = 45.8 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 17/162 (10%), Positives = 46/162 (28%), Gaps = 18/162 (11%) Query: 4 ILVSAGYDHTIRFWEALTGVC-SRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRT 62 +++ D I ++ +I + ++ ++ + D T+ + + Sbjct: 167 YIIAGHKDGKISKYDVSNNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNS-FLVDV 225 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSED--GTIKVWDVRSPSIPRNY------- 113 + + +E + + +++ + + Sbjct: 226 STLQVLKKYET-DCPLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYHKIFEE 284 Query: 114 ------KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQ 149 H P+N V I P S DG IR+ ++ Sbjct: 285 EIGRVQGHFGPLNTVAISPQGTSYASGGEDGFIRLHHFEKSY 326 Score = 39.7 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 21/131 (16%), Positives = 42/131 (32%), Gaps = 18/131 (13%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRT 62 +++ D + T + + +D +N IT K+ + G Q + D+ T Sbjct: 209 TYFITSSRDTNSFLVDVSTLQVLKKYE-TDCPLNTAVITPLKEFIILGGGQEAK--DVTT 265 Query: 63 TN---------------PNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSP 107 T+ + +GH G + +V+ + EDG I++ Sbjct: 266 TSANEGKFEARFYHKIFEEEIGRVQGHFGPLNTVAISPQGTSYASGGEDGFIRLHHFEKS 325 Query: 108 SIPRNYKHNAP 118 Y Sbjct: 326 YFDFKYDVEKA 336 >2HES-X nrPDB Length = 330 Score = 122 bits (306), Expect = 2e-28, Method: Composition-based stats. Identities = 57/304 (18%), Positives = 106/304 (34%), Gaps = 27/304 (8%) Query: 4 ILVSAGYDHTIRF----WEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLY 58 IL + D I+ ++ T + + + LLA V ++ Sbjct: 26 ILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSFDSTVSIW 85 Query: 59 DI-----RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDV-----RSPS 108 RT + +A EGH V V++ D ++ T S D ++ +W+ Sbjct: 86 AKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYEC 145 Query: 109 IPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGEN--QCTHQLTPEDDTSLQSLS 166 I +H+ V V+ HP++ L S D +RIW ++ +C L + T S Sbjct: 146 ISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDF 205 Query: 167 MASDGSM-LAAANTKGNCYVWEMPNHTDASHLKPVTKF---RAHSTYITRILLSSDVKHL 222 ++G L + + VW+ + + V + H + + + + Sbjct: 206 DKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNG-LI 264 Query: 223 ATCSADHTARVW-SIDDDFKLETTLDG-HQ-RWVWDCAF--SADSAYLVTASSDHYVRLW 277 A+ AD V+ +D ++K+ H + + L T D V W Sbjct: 265 ASVGADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVKWLELNGKTILATGGDDGIVNFW 324 Query: 278 DLST 281 L Sbjct: 325 SLEK 328 Score = 108 bits (269), Expect = 4e-24, Method: Composition-based stats. Identities = 47/261 (18%), Positives = 92/261 (35%), Gaps = 24/261 (9%) Query: 2 SVILVSAGYDHTIRFW-------EALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQ 53 + +L + +D T+ W I+ +++V + +ND LAT + Sbjct: 70 TSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDK 129 Query: 54 NVRLY--DIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW---DVRSPS 108 +V ++ D ++ + H +V V + + +SS D T+++W D Sbjct: 130 SVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDDWEC 189 Query: 109 IPRNYKHNAPVNEVVIHPNQG--ELISCDRDGNIRIW--------DLGENQCTHQLTPED 158 + H V +G L S D +R+W D E C L Sbjct: 190 VAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVH 249 Query: 159 DTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSD 218 + +++ +G ++A+ G V+E + K + + + L + Sbjct: 250 KRQVYNVAWGFNG-LIASVGADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVKWLELNG 308 Query: 219 VKHLATCSADHTARVWSIDDD 239 LAT D WS++ Sbjct: 309 KTILATGGDDGIVNFWSLEKA 329 Score = 105 bits (262), Expect = 2e-23, Method: Composition-based stats. Identities = 38/189 (20%), Positives = 72/189 (38%), Gaps = 9/189 (4%) Query: 123 VIHPNQGELISCDRDGNIRIWDLGENQCTHQL---TPEDDTSLQSLSMASDGSMLAAANT 179 +QG L + D I++ + + T +++S++ S+LAA + Sbjct: 19 SFDFSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSF 78 Query: 180 KGNCYVWEMPNHTDAS-HLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDD 238 +W D + + + H + + S+D +LATCS D + +W D+ Sbjct: 79 DSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDE 138 Query: 239 ---DFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDL--STREIVRQYGGHHK 293 +++ + L H + V + A L ++S D VR+W E V GH Sbjct: 139 SGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDDWECVAVLNGHEG 198 Query: 294 GAVCVALND 302 + Sbjct: 199 TVWSSDFDK 207 Score = 27.0 bits (58), Expect = 9.9, Method: Composition-based stats. Identities = 10/35 (28%), Positives = 17/35 (48%), Gaps = 2/35 (5%) Query: 242 LETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRL 276 L +L ++ +W FS L T S+D ++L Sbjct: 6 LIKSLKLYKEKIWSFDFS--QGILATGSTDRKIKL 38 >3BG0-A nrPDB Length = 316 Score = 120 bits (302), Expect = 5e-28, Method: Composition-based stats. Identities = 53/281 (18%), Positives = 105/281 (37%), Gaps = 37/281 (13%) Query: 31 SDSQVNRLEITNDK-KLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQD--N 87 + ++ ++ +L + ++V+++D+R +A GH G V V++ Sbjct: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 Query: 88 RWMVTSSEDGTIKVWDVRSPSIPRNY---KHNAPVNEVVIHPNQGELIS--CDRDGNIRI 142 + + S D + +W + + +++ H++ VN V P+ LI DG I + Sbjct: 72 NILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131 Query: 143 WDL-GENQC-THQLTPEDDTSLQSLSMAS---DGSM--------------LAAANTKGNC 183 GE Q ++ ++S A GS+ A+ Sbjct: 132 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLI 191 Query: 184 YVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDV----KHLATCSADHTARVWSIDDD 239 +W+ + K K AHS ++ + + + +A+CS D +W+ DD Sbjct: 192 KLWK---EEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDA 248 Query: 240 FKL---ETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 L VW ++S + L + D+ V LW Sbjct: 249 SSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 Score = 86.7 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 41/219 (18%), Positives = 71/219 (32%), Gaps = 34/219 (15%) Query: 3 VILVSAGYDHTIRFWEALTGV--CSRTIQHSDSQVNRLEITN--DKKLLAT-AGHQNVRL 57 IL S YD + W G S DS VN + +LA + + L Sbjct: 72 NILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131 Query: 58 YDIRTTNPNPVASFE-GHRGNVTSVSF-----------QQDNRW------MVTSSEDGTI 99 V H +VS+ + + D I Sbjct: 132 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLI 191 Query: 100 KVW----DVRSPSIPRNYKHNAPVNEVVIHPN----QGELISCDRDGNIRIW---DLGEN 148 K+W D + + H+ V +V P+ + SC +DG + IW D N Sbjct: 192 KLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSN 251 Query: 149 QCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWE 187 + +L + + + +S + ++LA + +W+ Sbjct: 252 TWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWK 290 Score = 64.7 bits (156), Expect = 5e-11, Method: Composition-based stats. Identities = 24/103 (23%), Positives = 41/103 (39%), Gaps = 5/103 (4%) Query: 201 TKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFK-LETTLDGHQRWVWDCAFS 259 T +H I + LATCS+D + +++ + + + L L GH+ VW A++ Sbjct: 7 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWA 66 Query: 260 A--DSAYLVTASSDHYVRLWDLSTREIVRQYG--GHHKGAVCV 298 L + S D V +W + + GH V Sbjct: 67 HPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSV 109 Score = 37.7 bits (86), Expect = 0.005, Method: Composition-based stats. Identities = 13/55 (23%), Positives = 21/55 (38%), Gaps = 2/55 (3%) Query: 247 DGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTRE--IVRQYGGHHKGAVCVA 299 H+ + D L T SSD V+++D+ ++ GH VA Sbjct: 10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVA 64 >4XFV-A nrPDB Length = 792 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 60/298 (20%), Positives = 107/298 (35%), Gaps = 50/298 (16%) Query: 30 HSDSQVNRLEITNDKKLLATAGHQNVRLYD-IRTTNPNPVASFEGHRGNVTSVSFQQDNR 88 ++ Q +I KK++A + + L+D I N A+ +GH VT V F D+ Sbjct: 17 GANKQTQVSDIHKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSD 76 Query: 89 WMVTSSEDGTIKVW---DVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDL 145 +MV++SED +K+W D + +H + V + + DG I IW Sbjct: 77 FMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSK-TIVALSALPSLISVGCADGTISIWRQ 135 Query: 146 G----ENQCTHQLTPEDDTS---LQSLSMASDGSM-LAAANTKGNCYVWE-MPNHTDASH 196 E H+ T + SLS + LA T N ++ + + + Sbjct: 136 NIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEK 195 Query: 197 LKPVTKFRAHSTYITRILL----SSDVKHLATCSADHTARVW---------SIDDDFKLE 243 + V + H ++ + + L + S D R+W ++D K Sbjct: 196 CRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKL 255 Query: 244 TTLD-----------------------GHQRWVWDCAFSADSAYLVTASSDHYVRLWD 278 T L GH W+ + L+ A++D + +W+ Sbjct: 256 TLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWE 313 Score = 98.6 bits (244), Expect = 3e-21, Method: Composition-based stats. Identities = 40/215 (18%), Positives = 77/215 (35%), Gaps = 17/215 (7%) Query: 88 RWMVTSSEDGTIKVWDV----RSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIW 143 + +V TI +WD H A V V P+ ++S D +++IW Sbjct: 31 KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIW 90 Query: 144 DLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKF 203 + + S +++++ S+++ G +W D L Sbjct: 91 KFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTI 150 Query: 204 RAHSTYITRILLSSDVKH---LATCSADHTARVWSI------DDDFKLETTLDGHQRWVW 254 + Y + LS + LA + + S + ++ L+GH+ WV Sbjct: 151 KKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVK 210 Query: 255 DCAF----SADSAYLVTASSDHYVRLWDLSTREIV 285 AF + L + S D Y+RLW + +++ Sbjct: 211 SLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLI 245 Score = 94.0 bits (232), Expect = 8e-20, Method: Composition-based stats. Identities = 54/343 (15%), Positives = 98/343 (28%), Gaps = 68/343 (19%) Query: 2 SVILVSAGYDHTIRFW---EALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLY 58 S +VSA DH ++ W + C +TIQH + L + + ++ Sbjct: 75 SDFMVSASEDHHVKIWKFTDYSHLQCIQTIQHYSKTIVALSALP-SLISVGCADGTISIW 133 Query: 59 --DIRTTNPNPVASFEGHRGNVTSVSFQ-----QDNRWMVTSSEDGTIKVWD-------V 104 +I+ F +G + + + + + + + Sbjct: 134 RQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGI 193 Query: 105 RSPSIPRNY-KHNAPVNEVVIH----PNQGELISCDRDGNIRIWDLGENQCT-------- 151 + H V + P L S +D IR+W + N Sbjct: 194 EKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSK 253 Query: 152 ------------------------HQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWE 187 L D + SL L AA + VWE Sbjct: 254 KLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWE 313 Query: 188 MPNHT----------DASHLKPVTKFRAHSTYITRILLSSDV-KHLATCSADHTARVWSI 236 + + S T + + + + + + T + R+W+ Sbjct: 314 PDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWAT 373 Query: 237 DDDFKLETTL--DGHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 D+ + L G + V D A+S YL+ S D RL+ Sbjct: 374 KDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLF 416 Score = 79.7 bits (195), Expect = 1e-15, Method: Composition-based stats. Identities = 59/359 (16%), Positives = 119/359 (33%), Gaps = 61/359 (16%) Query: 4 ILVSAGYDHTIRFWEA-LTGVCSRTI--QHSDSQVNRLEITNDKKLL-ATAGHQNVRLYD 59 ++ G + R W +C + + + V + + + L AT+ Q RL+ Sbjct: 358 FFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFA 417 Query: 60 I----RTTNPNPVASF------EGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSI 109 + +A++ + H ++ V D R V+ ++ ++ +D+ Sbjct: 418 PWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTR-FVSGGDEKILRSFDLPKGVA 476 Query: 110 -------------PRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLT- 155 +A V + + GE + + D + T L+ Sbjct: 477 GMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSL 536 Query: 156 ----------------------PEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTD 193 + L ++ D ++A+A N + + Sbjct: 537 LECPPMEDQLQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFST 596 Query: 194 ASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI---DDDFKLETTLD-GH 249 + L+ HS ITR+ S D K L + D +W D+ F+L + H Sbjct: 597 ENWLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPH 656 Query: 250 QRWVWDCAFSA--DSAYLVTASSDHYVRLWDLSTRE----IVRQYGGHHKGAVCVALND 302 R +WD ++ VTAS D V++W ++ H K ++++D Sbjct: 657 TRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHD 715 Score = 75.5 bits (184), Expect = 3e-14, Method: Composition-based stats. Identities = 34/234 (14%), Positives = 91/234 (38%), Gaps = 27/234 (11%) Query: 28 IQHSDSQVNRLEITNDKKLLATAGHQN------VRLYDIRTTNPNPVASFEGHRGNVTSV 81 + ++ L+I+ D+KL+A+A N +R++ A H +T + Sbjct: 558 LYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPA-LPFHSLTITRL 616 Query: 82 SFQQDNRWMVTSSEDGTIKVW--DVRSPSIPRNYKHNAP----VNEVVIHP--NQGELIS 133 F +D +++++ D +W ++ + +K+ P + + P ++ Sbjct: 617 KFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVT 676 Query: 134 CDRDGNIRIWDLGE---NQCTHQLTPEDDTSLQSLSMA----SDGSMLAAANTKGNCYVW 186 RD +++W + + + + + ++ ++S+ + +++ G Y++ Sbjct: 677 ASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLY 736 Query: 187 EMPNHTDASHLKPVTKFRAHSTYITRILLS---SDVKHLA-TCSADHTARVWSI 236 + + ITR+ S + K S+D + R++S+ Sbjct: 737 SYTLGKFELITQLNEDITP-ADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYSL 789 Score = 68.2 bits (165), Expect = 4e-12, Method: Composition-based stats. Identities = 31/191 (16%), Positives = 64/191 (33%), Gaps = 15/191 (7%) Query: 107 PSIPRNYKHNAPVNEVVIHPNQGELISCD-----RDGNIRIWDLGENQCTHQLTPEDDTS 161 P + + Y H + + I P+Q + S ++ IRI+ P + Sbjct: 553 PEVEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLT 612 Query: 162 LQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSD--V 219 + L + DG L + +WE + L+ + + H+ I + Sbjct: 613 ITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNE-KPHTRIIWDADWAPLEFG 671 Query: 220 KHLATCSADHTARVWSIDDDFKLETTLDG---HQRWVWDCAFSAD---SAYLVTAS-SDH 272 T S D T +VW + + L+ H + V + L++ + Sbjct: 672 NVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENG 731 Query: 273 YVRLWDLSTRE 283 + L+ + + Sbjct: 732 EIYLYSYTLGK 742 Score = 67.0 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 35/242 (14%), Positives = 78/242 (32%), Gaps = 37/242 (15%) Query: 68 VASFEGHRGNVTSVSFQQDNRWMVTSSEDG-----TIKVWDVRSPSIPRNYK--HNAPVN 120 V GH +T + D + + ++ I+++ + + H+ + Sbjct: 555 VEKLYGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTIT 614 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASD------GSML 174 + + L+S RD +W+ T +L +++ + +D G++ Sbjct: 615 RLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVF 674 Query: 175 AAANTKGNCYVW--------EMPNHTDASHLKPVTKFRAHSTYI-----TRILLSSDVKH 221 A+ VW + H K VT H + I + L + + Sbjct: 675 VTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIY 734 Query: 222 LATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSA---DSAYLV-TASSDHYVRLW 277 L + +T + + + T + +S + + SSD R++ Sbjct: 735 LYS----YTLGKFELITQLNEDITPA---DKITRLRWSHLKRNGKLFLGVGSSDLSTRIY 787 Query: 278 DL 279 L Sbjct: 788 SL 789 Score = 57.4 bits (137), Expect = 7e-09, Method: Composition-based stats. Identities = 23/85 (27%), Positives = 41/85 (48%), Gaps = 5/85 (5%) Query: 220 KHLATCSADHTARVWSI--DDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 K + A T +W ++ + TL GH+ V F DS ++V+AS DH+V++W Sbjct: 31 KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIW 90 Query: 278 ---DLSTREIVRQYGGHHKGAVCVA 299 D S + ++ + K V ++ Sbjct: 91 KFTDYSHLQCIQTIQHYSKTIVALS 115 Score = 39.7 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 18/122 (14%), Positives = 43/122 (35%), Gaps = 18/122 (14%) Query: 3 VILVSAGYDHTIRFWE-----ALTGVCSRTIQHSDSQVNRLEITN---DKKLLATAG--H 52 + V+A D T++ W A V +I+ V + I + +K+L + G + Sbjct: 672 NVFVTASRDKTVKVWRHQKEPADDYVLEASIK-HTKAVTAISIHDSMIREKILISVGLEN 730 Query: 53 QNVRLYDIRTTNPNPVASFEGH---RGNVTSVSFQQ---DNRWMV-TSSEDGTIKVWDVR 105 + LY + +T + + + + + S D + +++ + Sbjct: 731 GEIYLYSYTLGKFELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYSLA 790 Query: 106 SP 107 Sbjct: 791 YE 792 Score = 36.6 bits (83), Expect = 0.014, Method: Composition-based stats. Identities = 20/168 (11%), Positives = 47/168 (27%), Gaps = 26/168 (15%) Query: 4 ILVSAGYDHTIRFW--EALTGVCSRTIQH---SDSQVNRLEITN---DKKLLATAGHQNV 55 L+S D W ++ + + + + + V Sbjct: 624 FLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTV 683 Query: 56 RLYDIRTTNPNPVASFEG---HRGNVTSVSFQQD---NRWMVT-SSEDGTIKVWDVRSPS 108 +++ + P E H VT++S + +++ E+G I ++ Sbjct: 684 KVWRHQ-KEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGK 742 Query: 109 IPRNYKHN------APVNEVVIHPNQGE----LISCDRDGNIRIWDLG 146 + N + + + L D + RI+ L Sbjct: 743 FELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYSLA 790 Score = 27.0 bits (58), Expect = 9.6, Method: Composition-based stats. Identities = 7/32 (21%), Positives = 11/32 (34%), Gaps = 3/32 (9%) Query: 272 HYVRLWDL---STREIVRQYGGHHKGAVCVAL 300 + LWD + + + GH CV Sbjct: 40 KTIALWDPIEPNNKGVYATLKGHEAEVTCVRF 71 >4OWR-A nrPDB Length = 339 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 50/290 (17%), Positives = 92/290 (31%), Gaps = 24/290 (8%) Query: 32 DSQVNRLEITNDKK----LLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDN 87 D + L + L+A + +VR ++++ + + + H G V V + D Sbjct: 10 DDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDG 69 Query: 88 RWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVI--HPNQGELISCDRDGNIRIWDL 145 + T+S D T K+WD+ S + +H+APV + PN +++ D ++ WD Sbjct: 70 SKVFTASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDT 129 Query: 146 GENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRA 205 + L + + M A + V+++ N Sbjct: 130 RSSNPMMVLQLPERCYCADVIY----PMAVVATAERGLIVYQLENQPSEFRRIESPLKHQ 185 Query: 206 HSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLET--TLDGHQR------------ 251 H + A S + + I+ + T H+ Sbjct: 186 HRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIY 245 Query: 252 WVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 V AF L T SD WD R ++ + N Sbjct: 246 AVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFN 295 Score = 60.1 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 33/239 (13%), Positives = 72/239 (30%), Gaps = 68/239 (28%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKL---LATAGHQNVRLYDIR 61 + +A D T + W+ + + I D+ V + + + + ++ +D R Sbjct: 72 VFTASCDKTAKMWDLSSNQAIQ-IAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTR 130 Query: 62 T--------------------------------------TNPNPVASFEG---HRGNVTS 80 + P+ E H+ Sbjct: 131 SSNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHR--C 188 Query: 81 VSFQQDNR----WMVTSSEDGTIKVWDVRSPSIPR---NYK-HNA------------PVN 120 V+ +D + S +G + + + P+ + +K H + VN Sbjct: 189 VAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVN 248 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANT 179 + HP G L + DG WD + + D + + +G++ A A++ Sbjct: 249 GIAFHPVHGTLATVGSDGRFSFWDKDARTKLKT-SEQLDQPISACCFNHNGNIFAYASS 306 >6ELZ-p nrPDB Length = 460 Score = 118 bits (296), Expect = 3e-27, Method: Composition-based stats. Identities = 50/321 (15%), Positives = 112/321 (34%), Gaps = 41/321 (12%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYD-- 59 S ++S YD +R W+ +G + + ++ ++ +L++ + +RL+ Sbjct: 115 SKHIISGSYDGIVRTWDL-SGNVQKQYSGHSGPIRAVKYISNTRLVSAGNDRTLRLWKTK 173 Query: 60 -------------------IRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIK 100 + + +A EGH+ V S+ DN ++++S D +I Sbjct: 174 NDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDVS-DNSRILSASYDNSIG 232 Query: 101 VWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWD--LGENQCTHQLTPED 158 W +I + P+ ++ +PN + + + + D + L Sbjct: 233 FWS----TIYKEMTVVDPLEDIN-NPNNKISTAARKRRKLTMKDGTIRRRAPLSLLESHT 287 Query: 159 DTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSD 218 Q + ++D ++ + + W++ S + I S Sbjct: 288 APVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDTRTT-------SYSLLSIAQLST 340 Query: 219 VKHLATCSADHTARVWSIDDDFKLETT---LDGHQRWVWDCAFSADSAY-LVTASSDHYV 274 + LA S+ + + T L GH+ +V ++ Y L + S D V Sbjct: 341 LNLLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTV 400 Query: 275 RLWDLSTREIVRQYGGHHKGA 295 ++WD+ + + K Sbjct: 401 KVWDVRSTSPMYTITREDKSV 421 Score = 88.6 bits (218), Expect = 3e-18, Method: Composition-based stats. Identities = 41/148 (27%), Positives = 68/148 (45%), Gaps = 13/148 (8%) Query: 7 SAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPN 66 S DHTI+ W+ +T C T S S ++ +++ L + +++ L+D R + Sbjct: 305 SVSQDHTIKTWDLVTARCIDTRTTSYSLLSIAQLSTLNLLACGSSARHITLHDPRVGASS 364 Query: 67 PV--ASFEGHRGNVTSVSFQQDNRWMV-TSSEDGTIKVWDVRSPSIPRNY---------K 114 V GH+ V+S+ +N +++ + S DGT+KVWDVRS S Sbjct: 365 KVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITREDKSVQKG 424 Query: 115 HNAPVNEVVIHPNQGELISCDRDGNIRI 142 N V V + +IS +D I+I Sbjct: 425 VNDKVFAVKWA-EKVGIISAGQDKKIQI 451 Score = 68.6 bits (166), Expect = 4e-12, Method: Composition-based stats. Identities = 41/236 (17%), Positives = 73/236 (30%), Gaps = 59/236 (25%) Query: 107 PSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLS 166 PS ++ + V+ + + +IS DG +R WDL Q + ++++ Sbjct: 94 PSYLNSFSNEDWVSSLDVGDGSKHIISGSYDGIVRTWDLS-GNVQKQYSGHSG-PIRAVK 151 Query: 167 MASDGSMLAAANTKGNCYVWEMPN-----------------HTDASHLKPVTKFRAHSTY 209 S+ L +A +W+ N + K + H Sbjct: 152 YISNTR-LVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAP 210 Query: 210 ITRILLSSDVKHLATCSADHTARVWS-------------------------IDDDFKL-- 242 + I +S D + + S D++ WS KL Sbjct: 211 VVSIDVS-DNSRILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLTM 269 Query: 243 ----------ETTLDGHQRWVWDCAF-SADSAYLVTASSDHYVRLWDLSTREIVRQ 287 + L+ H V F S D+ + S DH ++ WDL T + Sbjct: 270 KDGTIRRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDT 325 Score = 60.5 bits (145), Expect = 9e-10, Method: Composition-based stats. Identities = 19/120 (15%), Positives = 46/120 (38%), Gaps = 26/120 (21%) Query: 206 HSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYL 265 + +++ + + KH+ + S D R W + + ++ GH + + +++ L Sbjct: 102 NEDWVSSLDVGDGSKHIISGSYDGIVRTWDLSGN--VQKQYSGHSGPIRAVKYISNTR-L 158 Query: 266 VTASSDHYVRLW-----------------------DLSTREIVRQYGGHHKGAVCVALND 302 V+A +D +RLW ++ + + GH V + ++D Sbjct: 159 VSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDVSD 218 Score = 41.6 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 10/62 (16%), Positives = 24/62 (38%), Gaps = 8/62 (12%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVN--------RLEITNDKKLLATAGHQNV 55 IL S +D T++ W+ + TI D V ++ +++ + + Sbjct: 390 ILCSGSHDGTVKVWDVRSTSPMYTITREDKSVQKGVNDKVFAVKWAEKVGIISAGQDKKI 449 Query: 56 RL 57 ++ Sbjct: 450 QI 451 >5FA5-B nrPDB Length = 367 Score = 118 bits (295), Expect = 4e-27, Method: Composition-based stats. Identities = 59/261 (22%), Positives = 103/261 (39%), Gaps = 17/261 (6%) Query: 22 GVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASF--EGHRGNVT 79 G CS +Q +++ V L ++ +L + V L+++ V+ F H V+ Sbjct: 96 GFCSAGVQ-TEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVS 154 Query: 80 SVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGE-LISCDRD 137 +VS V+ S+D IKVWD+ + +Y+ H A V V P++ +SC D Sbjct: 155 TVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSED 214 Query: 138 GNIRIWDLGENQCTHQLT-PEDDTSLQSLSMASD-GSMLAAANTKGNCYVWEMPNHTDAS 195 I +WD + Q+ SL+ + + G + + + + Sbjct: 215 NRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTS--- 271 Query: 196 HLKPVTKFRAHSTYITRILLSSDV-KHLATCSADHTARVWSIDDDFKLETTLDGHQRWVW 254 V HS +T ++ S LA+ S D + V +D H+ +V Sbjct: 272 ---CVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAV--LDSSLSELFRSQAHRDFVR 326 Query: 255 DCAFSA-DSAYLVTASSDHYV 274 D +S + + L T DH V Sbjct: 327 DATWSPLNHSLLTTVGWDHQV 347 Score = 77.8 bits (190), Expect = 5e-15, Method: Composition-based stats. Identities = 41/280 (14%), Positives = 88/280 (31%), Gaps = 23/280 (8%) Query: 32 DSQVNRLEITNDKKLLATAGHQNVRLYD----------IRTTNPNPVASFEGHRGNVTSV 81 + Q+ +D LL A + R + A + G V + Sbjct: 53 ERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAG-VADL 111 Query: 82 SFQQDNRWMVTSSEDGTIKVWDVRSPSIPR-----NYKHNAPVNEVVIHPNQGELISCDR 136 ++ R ++ +S+ G +++W++ Y+H+ V+ V + + + +S + Sbjct: 112 TWV-GERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSK 170 Query: 137 DGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASH 196 D I++WDL + + S+ + + +W+ AS Sbjct: 171 DICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQ 230 Query: 197 LKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDC 256 + + + + T + + H + V Sbjct: 231 IGCSAPGYL---PTSLAWHPQQSEVFVFGDENGTVSLVD-TKSTSCVLSSAVHSQCVTGL 286 Query: 257 AFSADS-AYLVTASSDHYVRLWDLSTREIVRQYGGHHKGA 295 FS S +L + S D + + D S E+ R H Sbjct: 287 VFSPHSVPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFV 325 Score = 76.3 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 35/188 (18%), Positives = 70/188 (37%), Gaps = 14/188 (7%) Query: 6 VSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITN--DKKLLATAGHQNVRLYDIRTT 63 VS D I+ W+ V + + +QV + + D L+ + + L+D R Sbjct: 166 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCP 225 Query: 64 NPNPVASFEGHRGNV---TSVSFQQDNRWMVT-SSEDGTIKVWDVRSPSIPRNYK-HNAP 118 P AS G TS+++ + E+GT+ + D +S S + H+ Sbjct: 226 KP---ASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQC 282 Query: 119 VNEVVIHPNQ-GELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMAS-DGSMLAA 176 V +V P+ L S D ++ + D ++ + ++ + + + S+L Sbjct: 283 VTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFR--SQAHRDFVRDATWSPLNHSLLTT 340 Query: 177 ANTKGNCY 184 Sbjct: 341 VGWDHQVV 348 Score = 70.5 bits (171), Expect = 8e-13, Method: Composition-based stats. Identities = 33/202 (16%), Positives = 72/202 (35%), Gaps = 17/202 (8%) Query: 109 IPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCT---HQLTPEDDTSLQSL 165 + A V ++ +G ++ G + +W+L EN+ E D + ++ Sbjct: 98 CSAGVQTEAGVADLTWVGERG-ILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTV 156 Query: 166 SMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSD-VKHLAT 224 S+ S G+ + + VW++ + ++ +RAH+ +T + S + Sbjct: 157 SVLSSGTQAVSGSKDICIKVWDL------AQQVVLSSYRAHAAQVTCVAASPHKDSVFLS 210 Query: 225 CSADHTARVWSID---DDFKLETTLDGHQRWVWDCAFSAD-SAYLVTASSDHYVRLWDLS 280 CS D+ +W ++ + G+ A+ S V + V L D Sbjct: 211 CSEDNRILLWDTRCPKPASQIGCSAPGY--LPTSLAWHPQQSEVFVFGDENGTVSLVDTK 268 Query: 281 TREIVRQYGGHHKGAVCVALND 302 + V H + + + Sbjct: 269 STSCVLSSAVHSQCVTGLVFSP 290 Score = 65.5 bits (158), Expect = 2e-11, Method: Composition-based stats. Identities = 27/148 (18%), Positives = 52/148 (35%), Gaps = 4/148 (2%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTI--QHSDSQVNRLEITNDKKLLATAGHQNVRLYDIR 61 + +S D+ I W+ + I L + + G +N + + Sbjct: 207 VFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVD 266 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDN-RWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVN 120 T + + V S H VT + F + ++ + SED ++ V D + R+ H V Sbjct: 267 TKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVR 326 Query: 121 EVVIHP-NQGELISCDRDGNIRIWDLGE 147 + P N L + D + + Sbjct: 327 DATWSPLNHSLLTTVGWDHQVVHHVVPT 354 Score = 55.8 bits (133), Expect = 2e-08, Method: Composition-based stats. Identities = 27/148 (18%), Positives = 58/148 (39%), Gaps = 8/148 (5%) Query: 162 LQSLSMASDGSMLAAANT-KGNCY---VWEMPNHTDASHLKPVTKFRAHSTYITRILLSS 217 L++ SDG++L A++ G C+ +W + A + + + + Sbjct: 56 LEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWV- 114 Query: 218 DVKHLATCSADHTARVWSIDDDFKLETTLD---GHQRWVWDCAFSADSAYLVTASSDHYV 274 + + S +W +D++ L + H V + + V+ S D + Sbjct: 115 GERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICI 174 Query: 275 RLWDLSTREIVRQYGGHHKGAVCVALND 302 ++WDL+ + ++ Y H CVA + Sbjct: 175 KVWDLAQQVVLSSYRAHAAQVTCVAASP 202 Score = 38.9 bits (89), Expect = 0.002, Method: Composition-based stats. Identities = 14/99 (14%), Positives = 34/99 (34%), Gaps = 2/99 (2%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIR 61 S + V + T+ + + C + V L + + ++ L + Sbjct: 250 SEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD 309 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTS-SEDGTI 99 ++ S + HR V ++ N ++T+ D + Sbjct: 310 SSLSELFRS-QAHRDFVRDATWSPLNHSLLTTVGWDHQV 347 >1NR0-A nrPDB Length = 611 Score = 115 bits (287), Expect = 3e-26, Method: Composition-based stats. Identities = 56/347 (16%), Positives = 117/347 (33%), Gaps = 57/347 (16%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLAT-AGHQNVRLYDIRTT 63 ++S D+T+ +E T V+ + D L A+ G + LY+ Sbjct: 163 IISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDG 222 Query: 64 NPNPVASFE-----GHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAP 118 V + H G+V +++ D + ++S D TIK+W+V + + + Sbjct: 223 TKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTR 282 Query: 119 VN--EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAA 176 + ++ I + L+S +G I + E Q+ + ++ +LS ++DG L + Sbjct: 283 IEDQQLGIIWTKQALVSISANGFINFVN-PELGSIDQVRYGHNKAITALSSSADGKTLFS 341 Query: 177 ANTKGNCYVWEMPNHTDASHLKPVTKF------------------RAHSTYI-------- 210 A+ +G+ W++ V H + Sbjct: 342 ADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVD 401 Query: 211 -------------TRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCA 257 + +S+D H ++S ++ + + A Sbjct: 402 SSKAVANKLSSQPLGLAVSADGDIAVAACYKH-IAIYSHGKLTEVPISYNS-----SCVA 455 Query: 258 FSADSAYLVTASSDHYVRLWDLSTREI--VRQYGGHHKGAVCVALND 302 S D ++ D V ++ LS + V+ H VA ++ Sbjct: 456 LSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIV-HPAEITSVAFSN 501 Score = 112 bits (281), Expect = 1e-25, Method: Composition-based stats. Identities = 57/312 (18%), Positives = 111/312 (35%), Gaps = 53/312 (16%) Query: 28 IQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQD 86 Q + + A+ H NVR++D T + G V +S+ + Sbjct: 55 YTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSE 114 Query: 87 NRWMVTSSED----GTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQG-ELISCDRDGNIR 141 ++ + E G + ++D + + + A +N V P++ +IS D + Sbjct: 115 SKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARA-MNSVDFKPSRPFRIISGSDDNTVA 173 Query: 142 IWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKP-V 200 I++ + E + S+ DGS+ A+ G ++ + T + Sbjct: 174 IFEGPPFKFKSTF-GEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFEDDS 232 Query: 201 TKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLD------------- 247 K AHS + + S D +A+ SAD T ++W++ K+E T+ Sbjct: 233 LKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVAT-LKVEKTIPVGTRIEDQQLGII 291 Query: 248 ------------------------------GHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 GH + + + SAD L +A ++ ++ W Sbjct: 292 WTKQALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSW 351 Query: 278 DLSTREIVRQYG 289 D+ST R + Sbjct: 352 DISTGISNRVFP 363 Score = 98.2 bits (243), Expect = 3e-21, Method: Composition-based stats. Identities = 32/245 (13%), Positives = 83/245 (33%), Gaps = 19/245 (7%) Query: 57 LYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-- 114 +Y + + + H T + + G +++WD + Sbjct: 41 VYTVPVGSLTDTEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIP 100 Query: 115 -HNAPVNEVVIHPNQGELISCDR--DGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDG 171 + PV ++ + + + ++ LT + ++ S+ Sbjct: 101 VFSGPVKDISWDSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQA-RAMNSVDFKPSR 159 Query: 172 SM-LAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHT 230 + + + ++E P K + F H+ ++ + + D A+ D T Sbjct: 160 PFRIISGSDDNTVAIFEGPP------FKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGT 213 Query: 231 ARVWSIDDDFKLETTLD------GHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREI 284 +++ D K D H V+ +S D + +AS+D +++W+++T ++ Sbjct: 214 IVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKV 273 Query: 285 VRQYG 289 + Sbjct: 274 EKTIP 278 Score = 94.4 bits (233), Expect = 6e-20, Method: Composition-based stats. Identities = 53/372 (14%), Positives = 121/372 (32%), Gaps = 98/372 (26%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQ-------HSDSQVNRLEITNDKKLLATAG-HQNV 55 + S G D TI + + G + + V L + D +A+A + + Sbjct: 204 LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTI 263 Query: 56 RLYDIRT---TNPNPVASF--------------------------------------EGH 74 +++++ T PV + GH Sbjct: 264 KIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSIDQVRYGH 323 Query: 75 RGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK--HNAPVNEVVIHPNQGELI 132 +T++S D + + ++ +G I WD+ + R + H + + ++G+L Sbjct: 324 NKAITALSSSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIK-TTSKGDLF 382 Query: 133 SCDRDGNIRIW------------------------------DLGENQCTHQLTPEDD--- 159 + D ++++ D+ C + Sbjct: 383 TVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADGDIAVAACYKHIAIYSHGKL 442 Query: 160 ------TSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRI 213 + +++++D +A +V+++ + + V H IT + Sbjct: 443 TEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIV-----HPAEITSV 497 Query: 214 LLSSDVKHLATCSADHTARVWSIDDDFKLETT--LDGHQRWVWDCAFSADSAYLVTASSD 271 S++ L +S+ ++F+L T H V ++S D+ L T S D Sbjct: 498 AFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLD 557 Query: 272 HYVRLWDLSTRE 283 + V +W+++ Sbjct: 558 NSVIVWNMNKPS 569 Score = 92.8 bits (229), Expect = 1e-19, Method: Composition-based stats. Identities = 39/279 (13%), Positives = 103/279 (36%), Gaps = 12/279 (4%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTI-QHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTT 63 L SA + I W+ TG+ +R + + ++ T+ L + ++++ + Sbjct: 339 LFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGS 398 Query: 64 NPNPVASFEGH-RGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEV 122 + + ++ D V + I ++ + + V Sbjct: 399 GVDSSKAVANKLSSQPLGLAVSADGDIAVAACY-KHIAIYSHGK---LTEVPISYNSSCV 454 Query: 123 VIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGN 182 + ++ + +D + ++ L + T + S++ +++G+ L A + Sbjct: 455 ALSNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRK 514 Query: 183 CYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKL 242 + + N+ + +H + H+ + + S D LAT S D++ VW+++ Sbjct: 515 VIPYSVANNFELAHTN---SWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDH 571 Query: 243 ETTLDG--HQRWVWDCAFSADSAYLVTASSDHYVRLWDL 279 + G V + + +V+A D ++ W++ Sbjct: 572 PIIIKGAHAMSSVNSVIWL-NETTIVSAGQDSNIKFWNV 609 Score = 67.4 bits (163), Expect = 8e-12, Method: Composition-based stats. Identities = 34/151 (22%), Positives = 67/151 (44%), Gaps = 12/151 (7%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQH--SDSQVNRLEITNDKKLLATAGHQNVRLYDIR 61 + G D + ++ +G ++ +++ + +N+ L A Q+ ++ Sbjct: 462 FVAVGGQDSKVHVYKL-SGASVSEVKTIVHPAEITSVAFSNNGAFLV-ATDQSRKVIPYS 519 Query: 62 TTNPNPVA---SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS---IPRNYKH 115 N +A S+ H V VS+ DN + T S D ++ VW++ PS I H Sbjct: 520 VANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAH 579 Query: 116 N-APVNEVVIHPNQGELISCDRDGNIRIWDL 145 + VN V+ N+ ++S +D NI+ W++ Sbjct: 580 AMSSVNSVIWL-NETTIVSAGQDSNIKFWNV 609 Score = 63.2 bits (152), Expect = 1e-10, Method: Composition-based stats. Identities = 25/155 (16%), Positives = 48/155 (30%), Gaps = 12/155 (7%) Query: 153 QLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITR 212 ++ E + G A+ + GN +W+ T T S + Sbjct: 53 EIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTH----ILKTTIPVFSGPVKD 108 Query: 213 ILLSSDVKHLATCSADHT----ARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAY-LVT 267 I S+ K +A ++ L G R + F + +++ Sbjct: 109 ISWDSESKRIAAVGEGRERFGHVFLFDTGTSN---GNLTGQARAMNSVDFKPSRPFRIIS 165 Query: 268 ASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 S D+ V +++ + +G H K V N Sbjct: 166 GSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNP 200 >5MWJ-A nrPDB Length = 337 Score = 113 bits (283), Expect = 9e-26, Method: Composition-based stats. Identities = 46/278 (16%), Positives = 96/278 (34%), Gaps = 18/278 (6%) Query: 9 GYDHTIRFWEALTGVCSRTIQ-----HSDSQVNRLEITNDK-KLLATAGHQNVRLYDIRT 62 G ++ W+ + + D+ + ++ D L+ + ++D+ Sbjct: 69 GGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAA 128 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNE 121 P A +++ D++ + DG I VWD+ + ++ R ++ H + Sbjct: 129 PTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASC 188 Query: 122 VVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKG 181 + I + +L + D +R WDL E + Q + SL G LA Sbjct: 189 IDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQ--IFSLGYCPTGEWLAVGMESS 246 Query: 182 NCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFK 241 N V + + H + + + + K + D+ W Sbjct: 247 NVEVLHVNKPDK-------YQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGAS 299 Query: 242 LETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDL 279 + + + V C S D Y+VT S D ++++ Sbjct: 300 IFQSKE--SSSVLSCDISVDDKYIVTGSGDKKATVYEV 335 Score = 112 bits (280), Expect = 2e-25, Method: Composition-based stats. Identities = 44/235 (18%), Positives = 82/235 (34%), Gaps = 14/235 (5%) Query: 5 LVSAGYDHTIRFWEAL--TGVCSRTIQHSDSQVNRLEITNDKKL-LATAGHQNVRLYDIR 61 L+ G T+ W+ T + S L I+ D K+ + N+ ++D+ Sbjct: 112 LIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDL- 170 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNE 121 N V F+GH + + D + T D T++ WD+R + + + + Sbjct: 171 -HNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFS 229 Query: 122 VVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKG 181 + P L N+ + + N+ ++ + SL A G + Sbjct: 230 LGYCPTGEWLAVGMESSNVEVLHV--NKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDN 287 Query: 182 NCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI 236 W P K S+ + +S D K++ T S D A V+ + Sbjct: 288 LLNAWRTPYGASIFQSKE-------SSSVLSCDISVDDKYIVTGSGDKKATVYEV 335 Score = 110 bits (274), Expect = 1e-24, Method: Composition-based stats. Identities = 43/234 (18%), Positives = 86/234 (36%), Gaps = 17/234 (7%) Query: 74 HRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSP------SIPRNYKHNAPVNEVVIHPN 127 H V +V+ R + T + G +KVWD+ P S + + + P+ Sbjct: 50 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPD 108 Query: 128 QGELISCDRDGNIRIWDLGENQCTHQLTPEDDTS-LQSLSMASDGSMLAAANTKGNCYVW 186 LI + IWDL + +L+++ D + + + GN VW Sbjct: 109 GCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVW 168 Query: 187 EMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTL 246 ++ N T V +F+ H+ + I +S+D L T D+T R W + + +L+ Sbjct: 169 DLHNQT------LVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ--Q 220 Query: 247 DGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVAL 300 ++ + +L V + ++ + + H + + Sbjct: 221 HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQ-LHLHESCVLSLKF 273 Score = 97.8 bits (242), Expect = 5e-21, Method: Composition-based stats. Identities = 34/188 (18%), Positives = 65/188 (34%), Gaps = 6/188 (3%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDI 60 S + S D I W+ R Q + ++I+ND L T G VR +D+ Sbjct: 153 SKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDL 212 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVN 120 R F + S+ + W+ E ++V V P + + H + V Sbjct: 213 REGRQLQQHDF---TSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVL 269 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 + +S +D + W ++ +S+ S ++ D + + Sbjct: 270 SLKFAYCGKWFVSTGKDNLLNAW--RTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGD 327 Query: 181 GNCYVWEM 188 V+E+ Sbjct: 328 KKATVYEV 335 Score = 90.9 bits (224), Expect = 6e-19, Method: Composition-based stats. Identities = 30/146 (20%), Positives = 59/146 (40%), Gaps = 3/146 (2%) Query: 158 DDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSS 217 + ++++++ + KG VW++ + + S + + YI L Sbjct: 50 HGEVVCAVTISNPTRHVYTGG-KGCVKVWDISHPGNKSPVSQLDCLNR-DNYIRSCKLLP 107 Query: 218 DVKHLATCSADHTARVWSIDDDFK-LETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRL 276 D L T +W + ++ L + A S DS + SD + + Sbjct: 108 DGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAV 167 Query: 277 WDLSTREIVRQYGGHHKGAVCVALND 302 WDL + +VRQ+ GH GA C+ +++ Sbjct: 168 WDLHNQTLVRQFQGHTDGASCIDISN 193 >5K0Y-T nrPDB Length = 329 Score = 111 bits (277), Expect = 4e-25, Method: Composition-based stats. Identities = 52/315 (16%), Positives = 98/315 (31%), Gaps = 75/315 (23%) Query: 28 IQHSDSQVNRLEITNDKKLLAT-AGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQD 86 +Q + + +++ + LL T A V ++ + N + ++ GH G V V D Sbjct: 6 LQGHERSITQIKYNREGDLLFTVAKDPIVNVW--YSVNGERLGTYMGHTGAVWCVDADWD 63 Query: 87 NRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGN------I 140 + ++T S D + ++WD + K N+ V ++ D + Sbjct: 64 TKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIM-FSTDKQMGYQCFV 122 Query: 141 RIWDLGENQCT-----HQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDAS 195 +DL + + P +D+ + S G + A + G N A Sbjct: 123 SFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGEL------NQYSAK 176 Query: 196 HLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVW--------------------- 234 + + + HS I I LS ++ T S D+TA+++ Sbjct: 177 SGEVLVNVKEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFRTEPPRELAA 236 Query: 235 -----------------SIDDDFKLETTLD----------------GHQRWVWDCAFSAD 261 + + GH + AF D Sbjct: 237 LSPNYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPD 296 Query: 262 SAYLVTASSDHYVRL 276 + D YVR+ Sbjct: 297 GKSYSSGGEDGYVRI 311 Score = 100 bits (250), Expect = 7e-22, Method: Composition-based stats. Identities = 34/253 (13%), Positives = 85/253 (33%), Gaps = 18/253 (7%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQN------VRLY 58 +++ D++ R W+ TG ++ ++S V ++ + + V + Sbjct: 67 VLTGSADNSCRLWDCETGKQLALLK-TNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFF 125 Query: 59 DIRT----TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK 114 D+R N P + +TS + ++ E G + + +S + N K Sbjct: 126 DLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVK 185 Query: 115 -HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSM 173 H+ +N++ + ++ +D +++D + E L +LS + + Sbjct: 186 EHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFRTEPPRELAALSPNYEHVV 245 Query: 174 LAAANTKGNCYVWEMPNHTDASHL------KPVTKFRAHSTYITRILLSSDVKHLATCSA 227 + + + + + + H I + D K ++ Sbjct: 246 VGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGE 305 Query: 228 DHTARVWSIDDDF 240 D R+ D + Sbjct: 306 DGYVRIHYFDPQY 318 Score = 53.9 bits (128), Expect = 7e-08, Method: Composition-based stats. Identities = 21/114 (18%), Positives = 47/114 (41%), Gaps = 18/114 (15%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRT 62 + V+A D+T + +++ T +T + ++ ++ + + + G Q D+ T Sbjct: 201 TMFVTASKDNTAKLFDSTTLEHQKTFR-TEPPRELAALSPNYEHVVVGGGQEA--MDVTT 257 Query: 63 TN---------------PNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKV 101 T+ +GH G + SV+F D + + EDG +++ Sbjct: 258 TSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRI 311 Score = 50.1 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 15/60 (25%), Positives = 24/60 (40%) Query: 242 LETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 L GH+R + ++ + L T + D V +W E + Y GH CV + Sbjct: 2 RPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDAD 61 >6CHG-D nrPDB Length = 439 Score = 108 bits (270), Expect = 3e-24, Method: Composition-based stats. Identities = 52/312 (16%), Positives = 117/312 (37%), Gaps = 34/312 (10%) Query: 23 VCSRTIQHSDSQVNRLEITNDKKLLA-TAGHQNVRLYDIRTTNPNP-VASFEG-HRGNVT 79 + T++ + V ++ + LA + + +YD+ + P + + G H +V Sbjct: 19 KLTHTLEVPVAAV-CVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTRSVQ 77 Query: 80 SVSFQQDNRWMVTSSEDGTIKVWDVRSP-SIPRNYKHNAPVNEVVIHPNQGELISCDRDG 138 SV + D R++ +S D K+WD+ P + YK + P+ + +++ + Sbjct: 78 SVCWSNDGRYLWSSGRDWYAKLWDMTQPTKCFQQYKFDGPLWSCHVVRWNVCIVTVVEEP 137 Query: 139 NIRIWDLGENQCTHQLTP---------EDDTSLQSLSMASDGSMLAAANTKGNCYVWEMP 189 + L + Q P +L + + S++ +KG +++ Sbjct: 138 TAYVLTLTDRQNAFHCFPLLEQDQDISGHGYTLVACPHPTIESIIITGTSKGWINAFQLD 197 Query: 190 -NHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI---------DDD 239 ++ + + + I +I++S +A +D T R + + Sbjct: 198 LESGFEDKIRCCYEEKIANANIKQIIISPSGTRIAINGSDRTIRQYQLIVEDNESEGGSS 257 Query: 240 FKLETTLD-GHQRWVWDCAF------SADSAYLVT---ASSDHYVRLWDLSTREIVRQYG 289 + L+ +Q + + + YLV SS H + LW+ S+ +VR Sbjct: 258 HSVSIELEHKYQDIINRLQWNTIFFSNHSGEYLVASAHGSSAHDLYLWETSSGSLVRVLE 317 Query: 290 GHHKGAVCVALN 301 G + + + N Sbjct: 318 GADEELLDIDWN 329 Score = 39.7 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 36/271 (13%), Positives = 76/271 (28%), Gaps = 43/271 (15%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQ-NVRLYDIR 61 L S+G D + W+ D + + + T + + + Sbjct: 86 RYLWSSGRDWYAKLWDMTQPTKCFQQYKFDGPLWSCHVVRWNVCIVTVVEEPTAYVLTLT 145 Query: 62 TTN--------PNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW--DVRSP---- 107 GH + + ++T + G I + D+ S Sbjct: 146 DRQNAFHCFPLLEQDQDISGHGYTLVACPHPTIESIIITGTSKGWINAFQLDLESGFEDK 205 Query: 108 --SIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDL----------GENQCTHQLT 155 NA + +++I P+ + D IR + L + + +L Sbjct: 206 IRCCYEEKIANANIKQIIISPSGTRIAINGSDRTIRQYQLIVEDNESEGGSSHSVSIELE 265 Query: 156 PEDDTSLQSLSM------ASDGSML---AAANTKGNCYVWEMPNHTDASHLKPVTKFRAH 206 + + L G L A ++ + Y+WE + + V Sbjct: 266 HKYQDIINRLQWNTIFFSNHSGEYLVASAHGSSAHDLYLWETSSGS------LVRVLEGA 319 Query: 207 STYITRILLSSDVKHLATCSADHT-ARVWSI 236 + I + +A+ + +WSI Sbjct: 320 DEELLDIDWNFYSMRIASNGFESGWVYMWSI 350 >5OQL-X nrPDB Length = 630 Score = 107 bits (268), Expect = 4e-24, Method: Composition-based stats. Identities = 43/261 (16%), Positives = 82/261 (31%), Gaps = 50/261 (19%) Query: 69 ASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPVNEVVIHPN 127 +++GH V QD +++VT D + V++ + + +H V + Sbjct: 240 KTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLKPIKAFTQHRDAVTGLAFRRG 299 Query: 128 QGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWE 187 +L SC +D +++W L E L D L ++ + ++ W+ Sbjct: 300 TNQLYSCSKDRTVKVWSLDELAYVETLFGHQDEILDIDALGQE-RCVSVGARDRTARYWK 358 Query: 188 MPNHTDA-------------------SHLKPVTKFRAHSTYITRILLSSDVKHLATCSAD 228 +P + + P + AH + R+ + D T S + Sbjct: 359 VPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASA--AHEGSMDRVAM-IDDDMFVTGSDN 415 Query: 229 HTARVWSIDDDFKLETTLDGH--------------------------QRWVWDCAFSADS 262 +WSI L H R + S Sbjct: 416 GDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQPRGITALRTLPYS 475 Query: 263 AYLVTASSDHYVRLWDLSTRE 283 + + S D +R+W LS + Sbjct: 476 DLIFSGSWDGCIRVWRLSEDK 496 Score = 99.8 bits (247), Expect = 1e-21, Method: Composition-based stats. Identities = 47/232 (20%), Positives = 76/232 (32%), Gaps = 21/232 (9%) Query: 68 VASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW---DVRSPSIPRNYKHNAPVNEVVI 124 F + G VTSV+ + T+++DG + W D+ P+ K Sbjct: 163 YTQFRWNSGTVTSVAVCP--PYAYTTTKDGYLTKWKLQDLPKNQWPQTTKKKPKKPPAPP 220 Query: 125 HPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCY 184 + D L + + DG + Sbjct: 221 KKRPERICFAKADAR--------KANDKTYQGHLKAPL-VVKASQDGKFVVTGGADKRLV 271 Query: 185 VWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLET 244 V+ A+ LKP+ F H +T + L +CS D T +VWS+D+ +E Sbjct: 272 VYN------AADLKPIKAFTQHRDAVTGLAFRRGTNQLYSCSKDRTVKVWSLDELAYVE- 324 Query: 245 TLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAV 296 TL GHQ + D + + D R W + + GG G+ Sbjct: 325 TLFGHQDEILDIDALGQERCVSVGARDRTARYWKVPEESQLVFRGGGEGGSS 376 Score = 81.3 bits (199), Expect = 4e-16, Method: Composition-based stats. Identities = 32/263 (12%), Positives = 77/263 (29%), Gaps = 50/263 (19%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITN-DKKLLATAGHQNVRLYDIRT 62 +V+ G D + + A + V L +L + + + V+++ + Sbjct: 260 FVVTGGADKRLVVYNAADLKPIKAFTQHRDAVTGLAFRRGTNQLYSCSKDRTVKVWSLD- 318 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSI------------- 109 V + GH+ + + R + + D T + W V S Sbjct: 319 -ELAYVETLFGHQDEILDIDALGQERCVSVGARDRTARYWKVPEESQLVFRGGGEGGSSN 377 Query: 110 -----------PRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPED 158 P + H ++ V + + ++ +G++ +W + + H + Sbjct: 378 TKKHKLPPGMDPASAAHEGSMDRVAMI-DDDMFVTGSDNGDLALWSIQRKKPLHVIARAH 436 Query: 159 DTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSD 218 ++ +++ P IT + Sbjct: 437 GLEPPI----------------------KLEDYSADEIPDPSIIPAPQPRGITALRTLPY 474 Query: 219 VKHLATCSADHTARVWSIDDDFK 241 + + S D RVW + +D + Sbjct: 475 SDLIFSGSWDGCIRVWRLSEDKR 497 Score = 60.5 bits (145), Expect = 8e-10, Method: Composition-based stats. Identities = 27/216 (12%), Positives = 65/216 (30%), Gaps = 51/216 (23%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLA-TAGHQNVRLYDIRTT 63 L S D T++ W T+ ++ ++ ++ ++ A + R + + Sbjct: 303 LYSCSKDRTVKVWSLDELAYVETLFGHQDEILDIDALGQERCVSVGARDRTARYWKVPEE 362 Query: 64 NPNPVA---------------------SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW 102 + + H G++ V+ D+ VT S++G + +W Sbjct: 363 SQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAMI-DDDMFVTGSDNGDLALW 421 Query: 103 DVRSPSIPRNYK--H--------------------------NAPVNEVVIHPNQGELISC 134 ++ H + + P + S Sbjct: 422 SIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQPRGITALRTLPYSDLIFSG 481 Query: 135 DRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASD 170 DG IR+W L E++ + ++ +++ Sbjct: 482 SWDGCIRVWRLSEDKRKLEAVGILGVGSETCENSTN 517 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 22/152 (14%), Positives = 46/152 (30%), Gaps = 37/152 (24%) Query: 184 YVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLE 243 V+ A T+FR +S +T + + + T + D W + D K + Sbjct: 147 KVYRRLASELAFDKATYTQFRWNSGTVTSVAVCPP--YAYTTTKDGYLTKWKLQDLPKNQ 204 Query: 244 -----------------------------------TTLDGHQRWVWDCAFSADSAYLVTA 268 T GH + S D ++VT Sbjct: 205 WPQTTKKKPKKPPAPPKKRPERICFAKADARKANDKTYQGHLKAPLVVKASQDGKFVVTG 264 Query: 269 SSDHYVRLWDLSTREIVRQYGGHHKGAVCVAL 300 +D + +++ + + ++ + H +A Sbjct: 265 GADKRLVVYNAADLKPIKAFTQHRDAVTGLAF 296 Score = 29.3 bits (64), Expect = 2.0, Method: Composition-based stats. Identities = 6/19 (31%), Positives = 9/19 (47%) Query: 2 SVILVSAGYDHTIRFWEAL 20 S ++ S +D IR W Sbjct: 475 SDLIFSGSWDGCIRVWRLS 493 >5N4A-A nrPDB Length = 771 Score = 107 bits (268), Expect = 4e-24, Method: Composition-based stats. Identities = 38/173 (21%), Positives = 70/173 (40%), Gaps = 5/173 (2%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRT 62 L +AG D +++ W + G+ T+ +DS V + D L NV + + + Sbjct: 117 TALATAGEDGSVKIW-SRNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGSNVVIKSLSS 175 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEV 122 +++ H G V V + N ++T ED KVWD + ++ + PV V Sbjct: 176 NAKQN--AWKAHDGVVLKVDWSPINHLIITGGEDCKYKVWDSFGRLLFQSGLFDYPVTSV 233 Query: 123 VIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLA 175 P+ +++ D ++ D S+ +LS +D + LA Sbjct: 234 AWAPSGELFAVGGF-NTLQLCD-RMGWAYSKIHLNDTGSIMTLSWTADSTQLA 284 Score = 98.2 bits (243), Expect = 4e-21, Method: Composition-based stats. Identities = 40/273 (14%), Positives = 89/273 (32%), Gaps = 27/273 (9%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKK----------LLATAGHQN 54 L + D TI W L G + + D+ + + Sbjct: 28 LFTCSDDQTIHKWNML-GEPEQKVSTLDAYFTDMHWYPVSSKKTQAGGTDVFAVACTDGS 86 Query: 55 VRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY- 113 V++ + S EGH+G S+ + D + T+ EDG++K+W R+ + Sbjct: 87 VKIL---SRTGRVEKSIEGHKGACISLRWSYDGTALATAGEDGSVKIWS-RNGMLRSTLA 142 Query: 114 KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSM 173 + ++PV +V + +L C G+ + + D + + + + Sbjct: 143 QADSPVYSIVWAYDCDQLCYCT--GSNVVIKSLSSNAKQNAWKAHDGVVLKVDWSPINHL 200 Query: 174 LAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARV 233 + VW+ S + + + +T + + + A +T ++ Sbjct: 201 IITGGEDCKYKVWD-------SFGRLLFQSGLFDYPVTSVAWAPSGELFAVGGF-NTLQL 252 Query: 234 WSIDDDFKLETTLDGHQRWVWDCAFSADSAYLV 266 + + +++ADS L Sbjct: 253 CD-RMGWAYSKIHLNDTGSIMTLSWTADSTQLA 284 Score = 80.5 bits (197), Expect = 8e-16, Method: Composition-based stats. Identities = 35/214 (16%), Positives = 74/214 (34%), Gaps = 21/214 (9%) Query: 74 HRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGE--- 130 H +V + N + T S+D TI W++ + +A ++ +P + Sbjct: 13 HSELTAAVGWNVWNE-LFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPVSSKKTQ 71 Query: 131 ------LISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCY 184 DG+++I + + + SL + DG+ LA A G+ Sbjct: 72 AGGTDVFAVACTDGSVKILS-RTGRVEKSIEGHKGACI-SLRWSYDGTALATAGEDGSVK 129 Query: 185 VWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLET 244 +W + + + + + I+ + D L + S+ + K + Sbjct: 130 IW-------SRNGMLRSTLAQADSPVYSIVWAYDCDQL-CYCTGSNVVIKSLSSNAK-QN 180 Query: 245 TLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWD 278 H V +S + ++T D ++WD Sbjct: 181 AWKAHDGVVLKVDWSPINHLIITGGEDCKYKVWD 214 Score = 67.0 bits (162), Expect = 9e-12, Method: Composition-based stats. Identities = 35/196 (17%), Positives = 65/196 (33%), Gaps = 18/196 (9%) Query: 115 HNAPVNEVVIHPNQGELISCDRDGNIRIWDL------GENQCTHQLTPEDDTSLQSL-SM 167 H+ V + EL +C D I W++ + T + S + Sbjct: 13 HSELTAAVGWNVW-NELFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPVSSKKTQ 71 Query: 168 ASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSA 227 A + A A T G+ + + + H + S D LAT Sbjct: 72 AGGTDVFAVACTDGSVKIL-------SRTGRVEKSIEGHKGACISLRWSYDGTALATAGE 124 Query: 228 DHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQ 287 D + ++WS + L +TL V+ ++ D L + + V + LS+ Sbjct: 125 DGSVKIWS--RNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGSNVV-IKSLSSNAKQNA 181 Query: 288 YGGHHKGAVCVALNDV 303 + H + V + + Sbjct: 182 WKAHDGVVLKVDWSPI 197 >3W15-A nrPDB Length = 368 Score = 107 bits (267), Expect = 6e-24, Method: Composition-based stats. Identities = 51/294 (17%), Positives = 102/294 (34%), Gaps = 57/294 (19%) Query: 41 TNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRW-MVTSSEDGTI 99 +++ ++L G +RL+D T P+A F+ H V S ++ NR ++SS DG+I Sbjct: 73 SHENQVLVAQGDGTLRLFDT-TFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSI 131 Query: 100 KVWD----------------------------VRSPSIPRNYKHNAPVNEVVIHPN-QGE 130 K+W ++ S K+ V + P+ Q Sbjct: 132 KIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNL 191 Query: 131 LISCDRDGNIRIWDLG--ENQCTHQLTPEDDTSLQSLSMASDGSML-AAANTKGNCYVWE 187 ++SC + ++D+ + + + + A +W+ Sbjct: 192 VLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWD 251 Query: 188 MP----NHTDASHLKPVTKF-RAHSTYITRILLSSD-VKHLATCSADHTARVW-SIDDDF 240 + N + + + AH I ++ S L + S D T R+W + +D Sbjct: 252 IRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDG 311 Query: 241 KLETT--------------LDGHQRWVWDCAFSADSA--YLVTASSDHYVRLWD 278 ET H +V+ +S Y+ + + D + +W+ Sbjct: 312 AKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 365 Score = 77.0 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 52/307 (16%), Positives = 105/307 (34%), Gaps = 60/307 (19%) Query: 38 LEITN--DKKLLATAGH-----QNVRLYDI---RTTNPNPVASFEGHRGNVTSVSFQQD- 86 ++ + D +L AG N +L+ + R+ V SF + + +++ + Sbjct: 16 VQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLT-QDCLFDLAWNESH 74 Query: 87 NRWMVTSSEDGTIKVWDVRSPSIPRNY--KHNAPVNEVVIH-PNQGELISCDRDGNIRIW 143 ++ + DGT++++D P +H V + N+ +S DG+I+IW Sbjct: 75 ENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIW 134 Query: 144 DLGENQCTHQLTP--------------------------EDDTSLQSLSMAS-DGSMLAA 176 Q LTP ++ + + D +++ + Sbjct: 135 SPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLS 194 Query: 177 ANTKGNCYVWEMPNHTDASHLKPVTKFRAHST-YITRILLSSDVKH-LATCSADHTARVW 234 + ++++ K F HS + + +AT D+ R+W Sbjct: 195 CSGNSYASLFDIR----LPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIW 250 Query: 235 SID----------DDFKLETTLDGHQRWVWDCAFSA-DSAYLVTASSDHYVRLW-DLSTR 282 I + + + H + +S S L++AS D R+W DLS Sbjct: 251 DIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSND 310 Query: 283 EIVRQYG 289 Y Sbjct: 311 GAKETYK 317 Score = 73.2 bits (178), Expect = 1e-13, Method: Composition-based stats. Identities = 45/278 (16%), Positives = 86/278 (30%), Gaps = 81/278 (29%) Query: 5 LVSAGYDHTIRFWE---------------------------ALTGVCSRTIQHSDSQVNR 37 +S+ +D +I+ W L I + + V + Sbjct: 122 FLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQ 181 Query: 38 LEITN--DKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRG-NVTSVSFQQDNRWMV-TS 93 + + +L+ +G+ L+DIR + +F H G + F + ++V T Sbjct: 182 AQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATG 241 Query: 94 SEDGTIKVWDVR----------SPSIPRNYK--HNAPVNEVVIHPNQ-GELISCDRDGNI 140 D I++WD+R + S H + +V P+ L+S D Sbjct: 242 GVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTC 301 Query: 141 RIW-DLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKP 199 RIW DL + ++ + Sbjct: 302 RIWRDLSNDGAKET----------------------------------YKTNSTDATKGS 327 Query: 200 VTKFRAHSTYITRILLSSDVK--HLATCSADHTARVWS 235 + F HS ++ S K ++A+ + D VW+ Sbjct: 328 IFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 365 Score = 50.1 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 19/138 (13%), Positives = 45/138 (32%), Gaps = 8/138 (5%) Query: 159 DTSLQSLSMAS--DGSMLAAANTK----GNCYVWEMPNHTDASHLKPVTKFRAHSTYITR 212 S + + D + AA + GN ++ + + + V F Sbjct: 10 GFSGYGVQYSPFFDNRLAVAAGSNFGLVGNGKLF-ILEIDRSGRIVEVNSFLTQDCLFDL 68 Query: 213 ILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSA-DSAYLVTASSD 271 S + D T R++ H+R V+ C ++ + +++S D Sbjct: 69 AWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWD 128 Query: 272 HYVRLWDLSTREIVRQYG 289 +++W ++ + Sbjct: 129 GSIKIWSPLRKQSLMTLT 146 Score = 48.5 bits (114), Expect = 3e-06, Method: Composition-based stats. Identities = 16/129 (12%), Positives = 44/129 (34%), Gaps = 29/129 (22%) Query: 4 ILVSAGYDHTIRFWEA----------LTGVCSRTIQHSDS-QVNRLEITNDKK--LLATA 50 ++ + G D+ IR W+ C I ++ + ++ + L++ + Sbjct: 237 VVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSAS 296 Query: 51 GHQNVRLY--------------DIRTTNPNPVASFEGHRGNVTSVSFQQDNR--WMVTSS 94 R++ + + +F H V + + ++ +++ Sbjct: 297 YDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTA 356 Query: 95 EDGTIKVWD 103 DG + VW+ Sbjct: 357 WDGNLFVWN 365 >5A9Q-2 nrPDB Length = 326 Score = 107 bits (266), Expect = 7e-24, Method: Composition-based stats. Identities = 50/269 (18%), Positives = 98/269 (36%), Gaps = 19/269 (7%) Query: 22 GVCSRTIQ--HSDSQVNRLEITNDKKL---------LATAGHQNVRLYDIRTTNPNPVAS 70 G+ +T++ H +V+ + + + +L +A +RL+ + N Sbjct: 60 GIQYKTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKV 119 Query: 71 FEGHRGNVTSVSFQQ-DNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQG 129 EGH + + F + + + + S+D T ++W++ H +P V HP + Sbjct: 120 LEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFVLH-SPGMSVCWHPEET 178 Query: 130 -ELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEM 188 +L+ +++G IR +DL Q L E L S + A + +W++ Sbjct: 179 FKLMVAEKNGTIRFYDLLAQQAILSLESE-QVPLMSAHWCLKNTFKVGAVAGNDWLIWDI 237 Query: 189 PNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDG 248 + + +PV RA + I S+ T A + I + L G Sbjct: 238 TRSSYPQNKRPVHMDRACLFRWSTI---SENLFATTGYPGKMASQFQIHHLGHPQPILMG 294 Query: 249 HQRWVWDCAFSADSAYLVTASSDHYVRLW 277 ++ V DH + W Sbjct: 295 SVAVGSGLSWHRTLPLCVIGG-DHKLLFW 322 Score = 61.6 bits (148), Expect = 4e-10, Method: Composition-based stats. Identities = 27/141 (19%), Positives = 49/141 (34%), Gaps = 20/141 (14%) Query: 159 DTSLQSLSMAS-----DGSMLAAANTK----GNCYVWEMPNHTDASHLKPVTKFRAHSTY 209 + + + G+++A G C E + K + F H Sbjct: 16 EDYVHVVEFNPFENGDSGNLIAYGGNNYVVIGTCTFQEEEADVEGIQYKTLRTFH-HGVR 74 Query: 210 ITRILLSSDVK--------HLATCSADHTARVWSIDDDFKLE-TTLDGHQRWVWDCAFSA 260 + I S + + T +AD R+++ D K E L+GH ++ F Sbjct: 75 VDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLEGHTDFINGLVFDP 134 Query: 261 D-SAYLVTASSDHYVRLWDLS 280 + + S DH R+W+L Sbjct: 135 KEGQEIASVSDDHTCRIWNLE 155 Score = 53.5 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 33/195 (16%), Positives = 57/195 (29%), Gaps = 19/195 (9%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTN 64 + S DHT R W + + HS KL+ + +R YD+ Sbjct: 140 IASVSDDHTCRIWNLEGVQTAHFVLHSPGMSVCWHPEETFKLMVAEKNGTIRFYDLLA-- 197 Query: 65 PNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPV---NE 121 + S E + + S + N + V + +WD+ S P+N PV Sbjct: 198 QQAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWLIWDITRSSYPQN---KRPVHMDRA 254 Query: 122 VVIHP---NQGELISCDRDGNI----RIWDLGENQCTHQLTPEDDTSLQSLSMASDGSML 174 + ++ + G + +I LG Q + LS + Sbjct: 255 CLFRWSTISENLFATTGYPGKMASQFQIHHLGHPQ---PILMGSVAVGSGLSWHRTLPLC 311 Query: 175 AAANTKGNCYVWEMP 189 W Sbjct: 312 VIGG-DHKLLFWVTE 325 Score = 37.0 bits (84), Expect = 0.011, Method: Composition-based stats. Identities = 12/64 (18%), Positives = 24/64 (37%), Gaps = 10/64 (15%) Query: 249 HQRWVWDCAFSADSAY--------LVTASSDHYVRLW--DLSTREIVRQYGGHHKGAVCV 298 H V A+S ++ T+++D +RL+ DL + + GH + Sbjct: 71 HGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVLEGHTDFINGL 130 Query: 299 ALND 302 + Sbjct: 131 VFDP 134 >2AQ5-A nrPDB Length = 402 Score = 101 bits (251), Expect = 4e-22, Method: Composition-based stats. Identities = 41/226 (18%), Positives = 81/226 (35%), Gaps = 22/226 (9%) Query: 73 GHRGNVTSVSFQQ-DNRWMVTSSEDGTIKVWDVRSPSIPRNY--------KHNAPVNEVV 123 GH V +++ ++ + + SED T+ VW++ + H V V Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVA 138 Query: 124 IHPN-QGELISCDRDGNIRIWDLGENQCTHQLTPE-DDTSLQSLSMASDGSMLAAANTKG 181 HP Q L+S D I +WD+G L P+ ++ S+ + DG+++ + Sbjct: 139 WHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCRDK 198 Query: 182 NCYVWEMPNHTDASHLKPVTKFRAHST-YITRILLSSDVKHLATC---SADHTARVWSID 237 V E T + R H + S+ K L T ++ +W Sbjct: 199 RVRVIEPRKGTVVAEKD-----RPHEGTRPVHAVFVSEGKILTTGFSRMSERQVALWDTK 253 Query: 238 DDFKLETTLDGHQRWVWDC-AFSADSAYLVTASS-DHYVRLWDLST 281 + + + F D+ + D +R +++++ Sbjct: 254 HLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITS 299 Score = 89.4 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 35/189 (18%), Positives = 61/189 (32%), Gaps = 16/189 (8%) Query: 107 PSIPRNYKHNAPVNEVVIHPNQGELI-SCDRDGNIRIWDLGENQCTHQLTP------EDD 159 ++P H APV ++ P+ +I S D + +W++ + L Sbjct: 72 KNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHT 131 Query: 160 TSLQSLSMASDG-SMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSD 218 + ++ ++L +A VW++ L P H I + S D Sbjct: 132 KRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGP----DVHPDTIYSVDWSRD 187 Query: 219 VKHLATCSADHTARVWSIDDDFKLETTLDGHQRW-VWDCAFSADSAYLVTAS---SDHYV 274 + T D RV + H+ F ++ L T S+ V Sbjct: 188 GALICTSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAVFVSEGKILTTGFSRMSERQV 247 Query: 275 RLWDLSTRE 283 LWD E Sbjct: 248 ALWDTKHLE 256 Score = 89.0 bits (219), Expect = 3e-18, Method: Composition-based stats. Identities = 35/219 (15%), Positives = 79/219 (36%), Gaps = 21/219 (9%) Query: 3 VILVSAGYDHTIRFWEALTG-------VCSRTIQHSDSQVNRLEITN--DKKLLATAGHQ 53 ++ S D T+ WE G T++ +V + LL+ Sbjct: 95 NVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDN 154 Query: 54 NVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIP--R 111 + ++D+ T + H + SV + +D + TS D ++V + R ++ + Sbjct: 155 VILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKGTVVAEK 214 Query: 112 NYKHNA--PVNEVVIHPNQGELISCDR----DGNIRIWDLGENQCTHQLTPEDDTSLQSL 165 + H PV+ V + +G++++ + + +WD + L D +S L Sbjct: 215 DRPHEGTRPVHAVFVS--EGKILTTGFSRMSERQVALWDTKHLEEPLSLQELDTSSGVLL 272 Query: 166 -SMASDGSML-AAANTKGNCYVWEMPNHTDASHLKPVTK 202 D +++ + +E+ + H + Sbjct: 273 PFFDPDTNIVYLCGKGDSSIRYFEITSEAPFLHYLSMFS 311 Score = 84.4 bits (207), Expect = 6e-17, Method: Composition-based stats. Identities = 23/134 (17%), Positives = 51/134 (38%), Gaps = 4/134 (2%) Query: 158 DDTSLQSLSMAS-DGSMLAAANTKGNCYVWEMPNHT-DASHLKPVTKFRAHSTYITRILL 215 + ++ + +++A+ + VWE+P+ +PV H+ + + Sbjct: 80 HTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAW 139 Query: 216 SSDV-KHLATCSADHTARVWSIDDDFKLETT-LDGHQRWVWDCAFSADSAYLVTASSDHY 273 L + D+ VW + + T D H ++ +S D A + T+ D Sbjct: 140 HPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCRDKR 199 Query: 274 VRLWDLSTREIVRQ 287 VR+ + +V + Sbjct: 200 VRVIEPRKGTVVAE 213 Score = 68.9 bits (167), Expect = 2e-12, Method: Composition-based stats. Identities = 26/107 (24%), Positives = 43/107 (40%), Gaps = 10/107 (9%) Query: 205 AHSTYITRILLSS-DVKHLATCSADHTARVWSIDDD------FKLETTLDGHQRWVWDCA 257 H+ + I + +A+ S D T VW I D + TL+GH + V A Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVA 138 Query: 258 FSADSA-YLVTASSDHYVRLWDLSTREIVRQYGG--HHKGAVCVALN 301 + + L++A D+ + +WD+ T V G H V + Sbjct: 139 WHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWS 185 Score = 44.3 bits (103), Expect = 6e-05, Method: Composition-based stats. Identities = 16/63 (25%), Positives = 24/63 (38%), Gaps = 8/63 (12%) Query: 248 GHQRWVWDCAFSA-DSAYLVTASSDHYVRLWDLSTR-------EIVRQYGGHHKGAVCVA 299 GH V D A+ + + + S D V +W++ E V GH K VA Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVA 138 Query: 300 LND 302 + Sbjct: 139 WHP 141 >5WLC-LJ nrPDB Length = 513 Score = 101 bits (251), Expect = 4e-22, Method: Composition-based stats. Identities = 45/195 (23%), Positives = 80/195 (41%), Gaps = 11/195 (5%) Query: 114 KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSM 173 +HN+ V + +P + ++I+ Q + D + S S SDG + Sbjct: 38 EHNS-VTHISFNPQHPHDFAVTSSTRVQIFSSRTRQVIKTFSRFKDV-VYSASFRSDGKL 95 Query: 174 LAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARV 233 L A + G V++ N + H T++T+ + D K LAT S D R+ Sbjct: 96 LCAGDATGLVSVYDSYN---PRTILLSINASTHPTHVTKF-HTQDNKILATASDDRVTRL 151 Query: 234 WSIDDDFKLETTLDGHQRWVWDCAFSADSAYLV-TASSDHYVRLWDLSTREIVRQYG-GH 291 W I + ++ + L G +V +F + +LV T S D +RL+D + Y H Sbjct: 152 WDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTRSSGSTPIYSLNH 211 Query: 292 HK---GAVCVALNDV 303 + + V+ + Sbjct: 212 DQPVENVIAVSPTQI 226 Score = 92.1 bits (227), Expect = 3e-19, Method: Composition-based stats. Identities = 45/276 (16%), Positives = 98/276 (35%), Gaps = 27/276 (9%) Query: 15 RFWEALTGVCSRTIQHSDSQVNRLEITNDKKL-LATAGHQNVRLYDIRTTNPNPVASFEG 73 R+W T ++ ++ +S V + A V+++ RT + +F Sbjct: 25 RYWRQYTS--AQLVKEHNS-VTHISFNPQHPHDFAVTSSTRVQIFSSRTRQ--VIKTFSR 79 Query: 74 HRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRN----YKHNAPVNEVVIHPNQG 129 + V S SF+ D + + G + V+D +P H V H Sbjct: 80 FKDVVYSASFRSDGKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVT--KFHTQDN 137 Query: 130 ELI-SCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSML-AAANTKGNCYVWE 187 +++ + D R+WD+ +++LS L A + G +++ Sbjct: 138 KILATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYD 197 Query: 188 MPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLD 247 + P+ H + ++ S + ++ + +VW + + KL Sbjct: 198 TRSSGST----PIYSLN-HDQPVENVIAVSPTQIVSCGG--NNFKVWDLTSNKKL-YERG 249 Query: 248 GHQRWVWDCAF-----SADSAYLVTASSDHYVRLWD 278 + V + S + L+ +S D +V+++D Sbjct: 250 NFNKAVTCLDYVENFDSPMQSALIASSLDGHVKVFD 285 Score = 92.1 bits (227), Expect = 3e-19, Method: Composition-based stats. Identities = 51/273 (18%), Positives = 98/273 (35%), Gaps = 14/273 (5%) Query: 13 TIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVA-SF 71 ++ + + T +T V +D KLL AG + + NP + S Sbjct: 62 RVQIFSSRTRQVIKTFSRFKDVVYSASFRSDGKLL-CAGDATGLVSVYDSYNPRTILLSI 120 Query: 72 EGHRGNVTSVSFQ-QDNRWMVTSSEDGTIKVWDVRSPSIPRN--YKHNAPVNEVVIHPNQ 128 F QDN+ + T+S+D ++WD+ + P+ V + P Sbjct: 121 NASTHPTHVTKFHTQDNKILATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAA 180 Query: 129 G-ELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWE 187 + + DG IR++D + T + D ++++ S +++ N VW+ Sbjct: 181 PHLVATGSYDGLIRLYDTRSSGSTPIYSLNHDQPVENVIAVSPTQIVSCGG--NNFKVWD 238 Query: 188 MPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLD 247 + ++ K Y+ S L S D +V+ D+F+++ Sbjct: 239 LTSNKKLYERGNFNKAVTCLDYVENFD-SPMQSALIASSLDGHVKVFDPLDNFQVKFG-W 296 Query: 248 GHQRWVWDCAFSAD----SAYLVTASSDHYVRL 276 V CA S + +LV S + + Sbjct: 297 KFSGPVLSCAVSPSTAQGNRHLVAGLSSGLLAI 329 Score = 79.7 bits (195), Expect = 1e-15, Method: Composition-based stats. Identities = 39/196 (19%), Positives = 69/196 (35%), Gaps = 19/196 (9%) Query: 4 ILVSAGYDHTIRFWEALTG-VCSRTIQHSDSQVNRLEITNDKKLLATAG--HQNVRLYDI 60 IL +A D R W+ + + V L L G +RLYD Sbjct: 139 ILATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDT 198 Query: 61 RTTNPNPVASFEGHRGNV-TSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAP 118 R++ P+ S H V ++ +V+ + KVWD+ S N Sbjct: 199 RSSGSTPIYSL-NHDQPVENVIAVSP--TQIVSCGGNNF-KVWDLTSNKKLYERGNFNKA 254 Query: 119 VNEVVI-----HPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDG-- 171 V + P Q LI+ DG+++++D +N + + + S +++ Sbjct: 255 VTCLDYVENFDSPMQSALIASSLDGHVKVFDPLDNFQV-KFGWKFSGPVLSCAVSPSTAQ 313 Query: 172 --SMLAAANTKGNCYV 185 L A + G + Sbjct: 314 GNRHLVAGLSSGLLAI 329 >5M89-A nrPDB Length = 329 Score = 101 bits (251), Expect = 5e-22, Method: Composition-based stats. Identities = 46/273 (16%), Positives = 100/273 (36%), Gaps = 17/273 (6%) Query: 6 VSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNP 65 G D + + + RT+ + V E T K ++ TA V++YD Sbjct: 67 AVGGLDGKLDIYSVVANKVERTLDIGE-PVTATEWTGTKVVIGTAK-GWVKVYDA----G 120 Query: 66 NPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIH 125 A+F+ H G VT ++ R + + D + +D+ + +A + H Sbjct: 121 RESATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGERVARGYADAALTTCAFH 180 Query: 126 PNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSML-AAANTKGNCY 184 P+ + + G+I ++ + T +Q+L+ + +G A + Sbjct: 181 PDGNLFAAGTQTGHILVFHTTTLEQAESFP--LGTPIQALAFSENGFWFAATGKGTSSVT 238 Query: 185 VWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADH-TARVWSIDDDFKLE 243 ++++ A+ +K + + + I ++LAT T ++++ E Sbjct: 239 IFDLRKSGAAAAVKELQ-----TGEVLSISWDYTGQYLATGGGTGVTVQMYTKATKSWSE 293 Query: 244 TTLDGHQRWVWDCAFSADSAYLVTASSDHYVRL 276 G V + ++ LV S + V + Sbjct: 294 PVRLG--MPVVGVKWGGEAKRLVVVSREGVVSV 324 Score = 78.2 bits (191), Expect = 4e-15, Method: Composition-based stats. Identities = 33/227 (14%), Positives = 60/227 (26%), Gaps = 48/227 (21%) Query: 86 DNRWMVTSSEDGTIKVWDVRSPSIPRNY-------------------------------- 113 +N DG + ++ V + + R Sbjct: 62 ENECAAVGGLDGKLDIYSVVANKVERTLDIGEPVTATEWTGTKVVIGTAKGWVKVYDAGR 121 Query: 114 ------KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSM 167 H PV + +HP L S D + +DL + D +L + + Sbjct: 122 ESATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGERVA--RGYADAALTTCAF 179 Query: 168 ASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHL-ATCS 226 DG++ AA G+ V+ A T I + S + AT Sbjct: 180 HPDGNLFAAGTQTGHILVFHTTTLEQAESFPL-------GTPIQALAFSENGFWFAATGK 232 Query: 227 ADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHY 273 + ++ + + V ++ YL T Sbjct: 233 GTSSVTIFDLRKSGAAAAVKELQTGEVLSISWDYTGQYLATGGGTGV 279 Score = 66.6 bits (161), Expect = 1e-11, Method: Composition-based stats. Identities = 21/158 (13%), Positives = 54/158 (34%), Gaps = 14/158 (8%) Query: 132 ISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNH 191 DG + I+ + N+ L + + + G+ + KG V++ Sbjct: 67 AVGGLDGKLDIYSVVANKVERTLDIGEPVTATEWT----GTKVVIGTAKGWVKVYDA--- 119 Query: 192 TDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQR 251 + F+ H+ +T + + + LA+ D + + ++ ++ Sbjct: 120 -----GRESATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGERVARGYA--DA 172 Query: 252 WVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYG 289 + CAF D + ++ ++ +T E + Sbjct: 173 ALTTCAFHPDGNLFAAGTQTGHILVFHTTTLEQAESFP 210 Score = 60.1 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 31/187 (16%), Positives = 63/187 (33%), Gaps = 9/187 (4%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRT 62 IL S G D + F++ TG ++D+ + D L A AG Q + T Sbjct: 143 RILASVGVDKSFVFYDLETGERVAR-GYADAALTTCAFHPDGNLFA-AGTQTGHILVFHT 200 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWM-VTSSEDGTIKVWDVRSPSIPRNYKH--NAPV 119 T SF + +++F ++ W T ++ ++D+R K V Sbjct: 201 TTLEQAESFPLGT-PIQALAFSENGFWFAATGKGTSSVTIFDLRKSGAAAAVKELQTGEV 259 Query: 120 NEVVIHPNQGELISCDRDG-NIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAAN 178 + L + G ++++ + + + + + L + Sbjct: 260 LSISWDYTGQYLATGGGTGVTVQMYTKATKSWSEPVR--LGMPVVGVKWGGEAKRLVVVS 317 Query: 179 TKGNCYV 185 +G V Sbjct: 318 REGVVSV 324 Score = 52.4 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 24/149 (16%), Positives = 52/149 (34%), Gaps = 7/149 (4%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQN--VRLYDI 60 + + I + T + + + L + + A G V ++D+ Sbjct: 184 NLFAAGTQTGHILVFHTTTLEQAESFPLGT-PIQALAFSENGFWFAATGKGTSSVTIFDL 242 Query: 61 R-TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDG-TIKVWDVRSPSIPRNYKHNAP 118 R + V + G V S+S+ +++ T G T++++ + S + P Sbjct: 243 RKSGAAAAVKELQ--TGEVLSISWDYTGQYLATGGGTGVTVQMYTKATKSWSEPVRLGMP 300 Query: 119 VNEVVIHPNQGELISCDRDGNIRIWDLGE 147 V V L+ R+G + + E Sbjct: 301 VVGVKWGGEAKRLVVVSREGVVSVLGKKE 329 Score = 44.3 bits (103), Expect = 6e-05, Method: Composition-based stats. Identities = 22/146 (15%), Positives = 43/146 (29%), Gaps = 13/146 (8%) Query: 143 WDLGENQCTHQLTPEDDTSL-QSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVT 201 W ++ Q D ++ Q+ S+ + A G ++ + + L Sbjct: 34 WATADDVAALQQVAYTDLNVTQASSLDLENECAAVGGLDGKLDIYSVVANKVERTLDI-- 91 Query: 202 KFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSAD 261 +T + + +A +V+ + T H V A Sbjct: 92 -----GEPVTATEWT--GTKVVIGTAKGWVKVYDAGRES---ATFQTHAGPVTGLAVHPG 141 Query: 262 SAYLVTASSDHYVRLWDLSTREIVRQ 287 L + D +DL T E V + Sbjct: 142 GRILASVGVDKSFVFYDLETGERVAR 167 >2PM9-A nrPDB Length = 416 Score = 99.4 bits (246), Expect = 2e-21, Method: Composition-based stats. Identities = 54/301 (17%), Positives = 119/301 (39%), Gaps = 37/301 (12%) Query: 33 SQVNRLEITNDK-KLLAT-----------AGHQNVRLYDI-RTTNPNPVASFEGHRGNVT 79 S+ ++DK LL + + ++ L+ + + P+AS + Sbjct: 13 SRTATFAWSHDKIPLLVSGTVSGTVDANFSTDSSLELWSLLAADSEKPIASLQVDSKF-N 71 Query: 80 SVSFQQDNRWMVTSSEDGTIKVWDVRS-----PSIPRNYKHNAPVNEVVIHPNQ-GELIS 133 + + +N+ + + ++G+++++ S+ R H++ V V + Q L S Sbjct: 72 DLDWSHNNKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLAS 131 Query: 134 CDRDGNIRIWDLG----ENQCTHQLTPEDDTS----LQSLSMASD-GSMLAAANTKGNCY 184 +G I IWD+ LTP S + SL+ + A+A + Sbjct: 132 GGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFAS 191 Query: 185 VWEMPNHTDASHLKPVTKFRAHSTYITRILLSS-DVKHLATCS---ADHTARVWSIDD-D 239 +W++ + HL + ++ + + +AT + D + +W + + + Sbjct: 192 IWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNAN 251 Query: 240 FKLETTLDGHQRWVWDCAF-SADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCV 298 L+T GHQ+ + + D L+++ D+ V LW+ + E + Q+ +G C Sbjct: 252 TPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQFPA--RGNWCF 309 Query: 299 A 299 Sbjct: 310 K 310 Score = 67.4 bits (163), Expect = 8e-12, Method: Composition-based stats. Identities = 33/216 (15%), Positives = 78/216 (36%), Gaps = 27/216 (12%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVR------ 56 +L S G + I W+ C+ + + +++ ++++ A +Q++ Sbjct: 127 NVLASGGNNGEIFIWDMN--KCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASA 184 Query: 57 -------LYDIRTTNPNPVASFEGHRGNVTS----VSFQQDNRW---MVTSSE-DGTIKV 101 ++D++ S+ + V + N T S+ D +I + Sbjct: 185 GSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILI 244 Query: 102 WDVRSPSIPRNY---KHNAPVNEVVI-HPNQGELISCDRDGNIRIWDLGENQCTHQLTPE 157 WD+R+ + P H + + H ++ L+S RD + +W+ + Q Sbjct: 245 WDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQFPAR 304 Query: 158 DDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTD 193 + ++ + A A+ V + N T+ Sbjct: 305 GNWCFKTKFAPEAPDLFACASFDNKIEVQTLQNLTN 340 Score = 63.9 bits (154), Expect = 7e-11, Method: Composition-based stats. Identities = 27/161 (16%), Positives = 57/161 (35%), Gaps = 14/161 (8%) Query: 1 MSVILVSAGYDHTIRFWEALTGVCSRTIQHSDS--------QVNRLEITNDKKLLATAGH 52 ++ + SAG + W+ + ++ V N ++ G Sbjct: 177 LAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGS 236 Query: 53 QN---VRLYDIRTTNPNPVASFEGHRGNVTSVSF-QQDNRWMVTSSEDGTIKVWDVRSPS 108 N + ++D+R N +GH+ + S+ + QD +++S D T+ +W+ S Sbjct: 237 DNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAE 296 Query: 109 IPRNYKHNA-PVNEVVIHPNQGELISC-DRDGNIRIWDLGE 147 + + P +L +C D I + L Sbjct: 297 QLSQFPARGNWCFKTKFAPEAPDLFACASFDNKIEVQTLQN 337 >5A9Q-0 nrPDB Length = 380 Score = 97.8 bits (242), Expect = 5e-21, Method: Composition-based stats. Identities = 40/162 (24%), Positives = 72/162 (44%), Gaps = 7/162 (4%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQ-VNRLEITNDKKLLATAGHQNVRLYDIRT- 62 +V+ G D I + A RTI ++DS ++ + ++L ++++D R Sbjct: 144 IVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSIGQLKIWDFRQQ 203 Query: 63 -TNPNPVASFEGHRGNVTSVSFQQDNRWMV-TSSEDGTIKVWDVRSPSIPRNY--KHNAP 118 P+ + S G R + V + + +V T +DG + +WDVR ++P + H A Sbjct: 204 GNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAE 263 Query: 119 VNEVVIHPNQGE-LISCDRDGNIRIWDLGENQCTHQLTPEDD 159 + EV HP+ E L +C DG++ WD + Sbjct: 264 MWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQG 305 Score = 84.7 bits (208), Expect = 4e-17, Method: Composition-based stats. Identities = 49/266 (18%), Positives = 98/266 (36%), Gaps = 35/266 (13%) Query: 47 LATAGHQN----VRLYDI-RTTNPNPVASFEG---------HRGNVTSVSFQQDNRWMVT 92 AT N + L+ I N + FEG H G+V + F D +V Sbjct: 32 FATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCDIRHHGDVMDLQFF-DQERIVA 90 Query: 93 SSEDGTIKVW----DVRSPSIPRNYK----HNAPVN-------EVVIHPNQGELISCDRD 137 +S G + V+ + ++ S+ + + H P + + N E+++ D Sbjct: 91 ASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTGVVCNNPEIVTVGED 150 Query: 138 GNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHL 197 G I ++ + + D ++L +++ +L N+ G +W+ + Sbjct: 151 GRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEIL-TVNSIGQLKIWDFRQQGNEPSQ 209 Query: 198 KPVTKFRAHSTYITRILLSSDVKHL-ATCSADHTARVWSIDDDFKLETTLDGHQRWVWDC 256 + + + + +H+ AT D +W + + L H+ +W+ Sbjct: 210 --ILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEV 267 Query: 257 AFSADSA-YLVTASSDHYVRLWDLST 281 F + +L T S D + WD ST Sbjct: 268 HFHPSNPEHLFTCSEDGSLWHWDAST 293 Score = 75.5 bits (184), Expect = 2e-14, Method: Composition-based stats. Identities = 51/291 (17%), Positives = 98/291 (33%), Gaps = 45/291 (15%) Query: 5 LVSAGYDHT---IRFWEALTG-------------VCSRTIQHSDSQVNRLEITNDKKLLA 48 + +D+ I W I+H V L+ + ++++A Sbjct: 32 FATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCDIRHH-GDVMDLQFFDQERIVA 90 Query: 49 TAGHQNVRLYDIRTTNPNPV-----ASFEGHRGNVT-------SVSFQQDNRWMVTSSED 96 + V ++ N + H G + +N +VT ED Sbjct: 91 ASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTGVVCNNPEIVTVGED 150 Query: 97 GTIKVWDVRSPSIPRNYKH--NAPVNEVVIHPNQGELISCDRDGNIRIWDL----GENQC 150 G I ++ R + ++ ++ V E+++ + G ++IWD E Sbjct: 151 GRINLFRADHKEAVRTIDNADSSTLHAVTFL-RTPEILTVNSIGQLKIWDFRQQGNEPSQ 209 Query: 151 THQLTPEDDTSLQSLSMASDG-SMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTY 209 LT D L + + ++A G +W++ T PV+ +AH Sbjct: 210 ILSLTG-DRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTM-----PVSLLKAHEAE 263 Query: 210 ITRILLSS-DVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFS 259 + + + +HL TCS D + W D +++L HQ S Sbjct: 264 MWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLF-HQGGRSSTFLS 313 Score = 58.2 bits (139), Expect = 5e-09, Method: Composition-based stats. Identities = 29/251 (11%), Positives = 64/251 (25%), Gaps = 39/251 (15%) Query: 85 QDNRWMVTSSEDGT---IKVWDVRS-------------PSIPRNYKHNAPVNEVVIHPNQ 128 Q T S D I +W + + + +H+ V ++ + Sbjct: 27 QTAETFATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCDIRHHGDVMDLQFFDQE 86 Query: 129 GELISCDRDGNIRIWD------LGENQCTHQLTPEDDTSLQSLSMAS------DGSMLAA 176 + + L NQ S S A + + Sbjct: 87 RIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTGVVCNNPEIVT 146 Query: 177 ANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI 236 G ++ + + H+ + + L S ++W Sbjct: 147 VGEDGRINLFRADHKEAVRTIDNADSSTLHA-----VTFLRTPEILTVNSI-GQLKIWDF 200 Query: 237 D---DDFKLETTLDGHQRWVWDCAFSADSAYLV-TASSDHYVRLWDLSTREI-VRQYGGH 291 ++ +L G + + + ++V T D + +WD+ + V H Sbjct: 201 RQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAH 260 Query: 292 HKGAVCVALND 302 V + Sbjct: 261 EAEMWEVHFHP 271 Score = 43.1 bits (100), Expect = 1e-04, Method: Composition-based stats. Identities = 11/76 (14%), Positives = 29/76 (38%), Gaps = 5/76 (6%) Query: 4 ILVSAGYDHTIRFWEALTGV-CSRTIQHSDSQVNRLEITNDKK--LLATAGHQNVRLYDI 60 ++ + G D + W+ G ++ ++++ + L + ++ +D Sbjct: 232 VVATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDA 291 Query: 61 RTTNPNPVASFEGHRG 76 T P + F H+G Sbjct: 292 STDVPEKSSLF--HQG 305 >5WLC-SG nrPDB Length = 573 Score = 97.4 bits (241), Expect = 6e-21, Method: Composition-based stats. Identities = 42/311 (13%), Positives = 88/311 (28%), Gaps = 75/311 (24%) Query: 60 IRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNA-- 117 I T+ + EGH + +V+ D +++VT D + VW S S + Sbjct: 221 IPTSKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRR 280 Query: 118 -PVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAA 176 V + N +L + D IR + + + L D ++ +S + + Sbjct: 281 GEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDI-VEDISALAMERCVTV 339 Query: 177 ANTKGNCYVWEMPNHT--------------------------------DASHLKPVTKFR 204 +W++P+ T P+ Sbjct: 340 GARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCE 399 Query: 205 AHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGH--------------- 249 ++ + D H T S + +WS+ + T H Sbjct: 400 GSIDVVSMV----DDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISGET 455 Query: 250 ----------------QRWVWDCAFSADSAYLVTASSDHYVRLW----DLSTREIVRQYG 289 W+ S ++ S +++W +L + E++ + Sbjct: 456 DEELRKRQLQGKKLLQPFWITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLGELS 515 Query: 290 GHHKGAVCVAL 300 G + + Sbjct: 516 GAKGVVTKIQV 526 Score = 33.5 bits (75), Expect = 0.10, Method: Composition-based stats. Identities = 5/49 (10%), Positives = 18/49 (36%), Gaps = 4/49 (8%) Query: 2 SVILVSAGYDHTIRFW----EALTGVCSRTIQHSDSQVNRLEITNDKKL 46 S + +S + +++ W + + + V ++++ K Sbjct: 484 SNVFISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVESGKH 532 >4E5Z-B nrPDB Length = 436 Score = 97.1 bits (240), Expect = 8e-21, Method: Composition-based stats. Identities = 43/223 (19%), Positives = 82/223 (36%), Gaps = 18/223 (8%) Query: 79 TSVSFQQDNR-WMVTSSEDGTIKVWDV---RSPSIPRNYKHNAPVNEVVIHP-NQGELIS 133 TS+++ + + S+ G I +W+ P+ + + + +P N + + Sbjct: 123 TSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYA 182 Query: 134 CDRDGNIRIWDLGENQCTHQLTPEDDTSL--QSLSMASDGSMLAAANTKGNCYVWEMPNH 191 +G R+ D D ++ SL +++ M+ + GN + M Sbjct: 183 SSMEGTTRLQDFK-GNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMD-- 239 Query: 192 TDASHLKPVTKFRAHSTYITRILLSSDVKH-LATCSADHTARVWSIDDDFKLETTLD--G 248 K + R H +T + L+ LAT S D T ++W + + L Sbjct: 240 -----GKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLP 294 Query: 249 HQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGH 291 H+ V FS D A L+T +R++ S + H Sbjct: 295 HRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPH 337 Score = 86.3 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 44/235 (18%), Positives = 87/235 (37%), Gaps = 25/235 (10%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDS---QVNRLEITNDKKLLATAGH-QNVRLYDI 60 ++ + T R + G R SD+ L+++ +++ T + NV L ++ Sbjct: 180 FYASSMEGTTRLQD-FKGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNM 238 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRW-MVTSSEDGTIKVWDVR----SPSIPRNYKH 115 + + H+ VT V+ W + T+S D T+K+WD+R S + H Sbjct: 239 DGKE---LWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPH 295 Query: 116 NAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSL-----SMASD 170 PVN P+ L++ D+ IR++ + C L P Q L + Sbjct: 296 RHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPR 355 Query: 171 GSMLAAA-NTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLAT 224 +++ N L+ + F +S + L + +++ Sbjct: 356 YNLIVVGRYPDPNFK------SCTPYELRTIDVFDGNSGKMMCQLYDPESSGISS 404 Score = 73.2 bits (178), Expect = 1e-13, Method: Composition-based stats. Identities = 40/292 (13%), Positives = 96/292 (32%), Gaps = 31/292 (10%) Query: 37 RLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQ-DNRWMVTSSE 95 T+ + + ++ L++ + G G++T + F + SS Sbjct: 126 AWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSM 185 Query: 96 DGTIKVWDVRSPSIPRNYKHNAPVN----EVVIHPNQGELISCDRDGNIRIWDLGENQCT 151 +GT ++ D +I R + + +N + + + +++ D GN+ + ++ + Sbjct: 186 EGTTRLQDF-KGNILRVFASSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELW 244 Query: 152 HQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYIT 211 + + + +L+ D LA A+ +W++ + H + Sbjct: 245 NLRMHKKKVTHVALNPCCD-WFLATASVDQTVKIWDLRQVRGKASFLYSL---PHRHPVN 300 Query: 212 RILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQR------WVWDCAFSADSAYL 265 S D L T RV+S + L H A+ + Sbjct: 301 AACFSPDGARLLTTDQKSEIRVYSASQ-WDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLI 359 Query: 266 VTA-SSD-----------HYVRLWDLSTREIV-RQYGGHHKGAVCV-ALNDV 303 V D + ++D ++ +++ + Y G + N + Sbjct: 360 VVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPM 411 Score = 45.8 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 32/176 (18%), Positives = 59/176 (33%), Gaps = 30/176 (17%) Query: 4 ILVSAGYDHTIRFWEAL----TGVCSRTIQHSDSQVNRLEITNDK-KLLATAGHQNVRLY 58 L +A D T++ W+ ++ VN + D +LL T +R+Y Sbjct: 265 FLATASVDQTVKIWDLRQVRGKASFLYSLP-HRHPVNAACFSPDGARLLTTDQKSEIRVY 323 Query: 59 DIRTTN------PNPVASFEGHRGNVTSVSFQQDNRWMVTSSE-D-----------GTIK 100 + P+P F+ H + + ++ +V D TI Sbjct: 324 SASQWDCPLGLIPHPHRHFQ-HLTPIKA-AWHPRYNLIVVGRYPDPNFKSCTPYELRTID 381 Query: 101 VWDVRSPS--IPRNYKHNAPVNEV-VIHPNQGELISCDRDGNIRIWDLGENQCTHQ 153 V+D S ++ ++ + +P L S +I IW E T + Sbjct: 382 VFDGNSGKMMCQLYDPESSGISSLNEFNPMGDTLASA-MGYHILIWSEQEEARTRK 436 >4J0X-A nrPDB Length = 451 Score = 96.7 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 42/311 (13%), Positives = 88/311 (28%), Gaps = 75/311 (24%) Query: 60 IRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNA-- 117 I T+ + EGH + +V+ D +++VT D + VW S S + Sbjct: 99 IPTSKHEYENTTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRR 158 Query: 118 -PVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAA 176 V + N +L + D IR + + + L D ++ +S + + Sbjct: 159 GEVLSLAFRKNSDQLYASCADFKIRTYSINQFSQLEILYGHHDI-VEDISALAMERCVTV 217 Query: 177 ANTKGNCYVWEMPNHT--------------------------------DASHLKPVTKFR 204 +W++P+ T P+ Sbjct: 218 GARDRTAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCE 277 Query: 205 AHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGH--------------- 249 ++ + D H T S + +WS+ + T H Sbjct: 278 GSIDVVSMV----DDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDISGET 333 Query: 250 ----------------QRWVWDCAFSADSAYLVTASSDHYVRLW----DLSTREIVRQYG 289 W+ S ++ S +++W +L + E++ + Sbjct: 334 DEELRKRQLQGKKLLQPFWITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLGELS 393 Query: 290 GHHKGAVCVAL 300 G + + Sbjct: 394 GAKGVVTKIQV 404 Score = 33.5 bits (75), Expect = 0.12, Method: Composition-based stats. Identities = 5/49 (10%), Positives = 18/49 (36%), Gaps = 4/49 (8%) Query: 2 SVILVSAGYDHTIRFW----EALTGVCSRTIQHSDSQVNRLEITNDKKL 46 S + +S + +++ W + + + V ++++ K Sbjct: 362 SNVFISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVESGKH 410 >6EM1-m nrPDB Length = 807 Score = 94.8 bits (234), Expect = 5e-20, Method: Composition-based stats. Identities = 52/334 (15%), Positives = 101/334 (30%), Gaps = 57/334 (17%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTI------QHSDSQVNRLEITNDKK--LLATAGHQNVR 56 L + D T+R WE LTG ++ D + +E D +LA A +N+ Sbjct: 452 LATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIH 511 Query: 57 L-------YDIRTTNPNPVASFEGHR--GNVTS--VSFQQDNRWMVTSSEDGT------- 98 L YDI + G+ G V + ++ EDG Sbjct: 512 LIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGD----GDEDGENESAKNA 567 Query: 99 ----IKVWDVRSPS-----IPRNYKHNAPVNEVVIHPNQGELISCDRD--GNIRIWDLGE 147 + W+ S I V ++ H ++ D + Sbjct: 568 VKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVS 627 Query: 148 NQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHS 207 T + + L + + ++++ S V K + Sbjct: 628 KHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRY-VRIYDL------SQQILVKKLLPGA 680 Query: 208 TYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVT 267 ++++I + +L S D +D TL H++ V F + Sbjct: 681 RWLSKIDIHPRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSS 740 Query: 268 ASSDHYVRLW------DLSTREI---VRQYGGHH 292 A+ D + ++ D+ + +++ GH Sbjct: 741 AADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHK 774 Score = 91.3 bits (225), Expect = 5e-19, Method: Composition-based stats. Identities = 34/213 (15%), Positives = 83/213 (38%), Gaps = 15/213 (7%) Query: 35 VNRLEITNDKKLLAT----AGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWM 90 V +L T +G+ +V ++ + + + F+ +G + F + Sbjct: 597 VKKLSWHRKGDYFVTVQPDSGNTSVLIH--QVSKHLTQSPFKKSKGIIMDAKFHPFKPQL 654 Query: 91 VTSSEDGTIKVWDVRSPSIPRNYKHNA-PVNEVVIHPNQGELISCDRDGNIRIWDLGENQ 149 S+ ++++D+ + + A ++++ IHP LI+ D + DL Sbjct: 655 FVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLAS 713 Query: 150 CTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVW---EMPNHTDASHLKPVTKFRAH 206 ++ + +++S++ + ++A G +V+ + + P+ K H Sbjct: 714 TPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGH 773 Query: 207 ----STYITRILLSSDVKHLATCSADHTARVWS 235 S + + L + AD+TAR+W+ Sbjct: 774 KVINSLGVLDAIWHPREAWLFSAGADNTARLWT 806 Score = 82.4 bits (202), Expect = 2e-16, Method: Composition-based stats. Identities = 45/297 (15%), Positives = 102/297 (34%), Gaps = 39/297 (13%) Query: 36 NRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSE 95 N+L I + + +++R + IR + GH+G V ++S W+ T S+ Sbjct: 403 NKLNIDPNSLIPELPSPKDLRPFPIR-----CSTIYAGHKGKVRTLSIDPSGLWLATGSD 457 Query: 96 DGTIKVWDVRSPSIPRNYKH-------NAPVNEVVIHPNQGELI---SCDRDGNIRI--- 142 DGT++VW++ + + + + +P+ I + + ++ + Sbjct: 458 DGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPI 517 Query: 143 --WDLGENQCTHQLTPEDDTSLQSLSMA-----------SDGSMLAAANT-KGNCYVWEM 188 +D+ N T + ++ + DG +A N K W Sbjct: 518 FGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNK 577 Query: 189 PNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADH---TARVWSIDDDFKLETT 245 P+ +T + + ++ + T D + + + Sbjct: 578 PSQKQLEKDICITI--SCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSP- 634 Query: 246 LDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 + + D F L S YVR++DLS + +V++ + + ++ Sbjct: 635 FKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHP 690 Score = 78.2 bits (191), Expect = 4e-15, Method: Composition-based stats. Identities = 49/312 (15%), Positives = 91/312 (29%), Gaps = 40/312 (12%) Query: 24 CSRTIQHSDSQVNRLEITNDKKLLATAGHQ-NVRLYDIRTTNPNPVASFEGHRGN----V 78 CS +V L I LAT VR+++I T + N + Sbjct: 429 CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHI 488 Query: 79 TSVSFQQD-NRWMVTSSEDGTIKV-------WDVRSP---SIPRNYKHNAPVNEVVIHPN 127 + + D N ++ + I + +D+ + I + ++ + Sbjct: 489 ECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLE 548 Query: 128 QGELISCDRDG-----------NIRIWDLGENQCTHQ---LTPEDDTSLQSLSMASDGSM 173 E D DG + W+ + + +T +++ LS G Sbjct: 549 VNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDY 608 Query: 174 LAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARV 233 + + P F+ I L CS R+ Sbjct: 609 FVTVQPDSGNTSVLIHQVSKHLTQSP---FKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRI 664 Query: 234 WSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW---DLSTREIVRQYGG 290 + + ++ L G RW+ L+ +S D V LW DL++ + Sbjct: 665 YDLSQQILVKKLLPG-ARWLSKIDIHPRGDNLIASSFDKRV-LWHDLDLAS-TPYKTLRY 721 Query: 291 HHKGAVCVALND 302 H K V + Sbjct: 722 HEKAVRSVNFHK 733 Score = 77.4 bits (189), Expect = 7e-15, Method: Composition-based stats. Identities = 42/219 (19%), Positives = 81/219 (36%), Gaps = 23/219 (10%) Query: 75 RGNVTSVSFQQDNRWMVTS---SEDGTIKVWDVRSPSIPRNYKHNAPV-NEVVIHPNQGE 130 + V +S+ + + VT S + ++ + V +K + + + HP + + Sbjct: 594 KKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQ 653 Query: 131 LISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPN 190 L C + +RI+DL + +L P L + + G L A++ ++ Sbjct: 654 LFVCSQ-RYVRIYDLSQQILVKKLLPGARW-LSKIDIHPRGDNLIASSFDKRVLWHDLDL 711 Query: 191 HTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVW---SIDDDFK-----L 242 + P R H + + + ++ + D T V+ DD K Sbjct: 712 AST-----PYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVP 766 Query: 243 ETTLDGH----QRWVWDCAFSADSAYLVTASSDHYVRLW 277 L GH V D + A+L +A +D+ RLW Sbjct: 767 LKKLTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 Score = 70.5 bits (171), Expect = 8e-13, Method: Composition-based stats. Identities = 27/156 (17%), Positives = 56/156 (35%), Gaps = 15/156 (9%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRT 62 L +R ++ + + + +++++I L + L+ Sbjct: 652 PQLFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLD 710 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWD-------VRSPSIP---RN 112 P + H V SV+F + ++++DGTI V+ +++P I + Sbjct: 711 LASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKL 770 Query: 113 YKHN----APVNEVVIHPNQGELISCDRDGNIRIWD 144 H V + + HP + L S D R+W Sbjct: 771 TGHKVINSLGVLDAIWHPREAWLFSAGADNTARLWT 806 >6C0F-s nrPDB Length = 807 Score = 93.6 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 52/334 (15%), Positives = 101/334 (30%), Gaps = 57/334 (17%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTI------QHSDSQVNRLEITNDKK--LLATAGHQNVR 56 L + D T+R WE LTG ++ D + +E D +LA A +N+ Sbjct: 452 LATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIH 511 Query: 57 L-------YDIRTTNPNPVASFEGHR--GNVTS--VSFQQDNRWMVTSSEDGT------- 98 L YDI + G+ G V + ++ EDG Sbjct: 512 LIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGD----GDEDGENESAKNA 567 Query: 99 ----IKVWDVRSPS-----IPRNYKHNAPVNEVVIHPNQGELISCDRD--GNIRIWDLGE 147 + W+ S I V ++ H ++ D + Sbjct: 568 VKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVS 627 Query: 148 NQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHS 207 T + + L + + ++++ S V K + Sbjct: 628 KHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRY-VRIYDL------SQQILVKKLLPGA 680 Query: 208 TYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVT 267 ++++I + +L S D +D TL H++ V F + Sbjct: 681 RWLSKIDIHPRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSS 740 Query: 268 ASSDHYVRLW------DLSTREI---VRQYGGHH 292 A+ D + ++ D+ + +++ GH Sbjct: 741 AADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHK 774 Score = 90.5 bits (223), Expect = 8e-19, Method: Composition-based stats. Identities = 34/213 (15%), Positives = 83/213 (38%), Gaps = 15/213 (7%) Query: 35 VNRLEITNDKKLLAT----AGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWM 90 V +L T +G+ +V ++ + + + F+ +G + F + Sbjct: 597 VKKLSWHRKGDYFVTVQPDSGNTSVLIH--QVSKHLTQSPFKKSKGIIMDAKFHPFKPQL 654 Query: 91 VTSSEDGTIKVWDVRSPSIPRNYKHNA-PVNEVVIHPNQGELISCDRDGNIRIWDLGENQ 149 S+ ++++D+ + + A ++++ IHP LI+ D + DL Sbjct: 655 FVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLAS 713 Query: 150 CTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVW---EMPNHTDASHLKPVTKFRAH 206 ++ + +++S++ + ++A G +V+ + + P+ K H Sbjct: 714 TPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGH 773 Query: 207 ----STYITRILLSSDVKHLATCSADHTARVWS 235 S + + L + AD+TAR+W+ Sbjct: 774 KVINSLGVLDAIWHPREAWLFSAGADNTARLWT 806 Score = 81.3 bits (199), Expect = 4e-16, Method: Composition-based stats. Identities = 45/297 (15%), Positives = 102/297 (34%), Gaps = 39/297 (13%) Query: 36 NRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSE 95 N+L I + + +++R + IR + GH+G V ++S W+ T S+ Sbjct: 403 NKLNIDPNSLIPELPSPKDLRPFPIR-----CSTIYAGHKGKVRTLSIDPSGLWLATGSD 457 Query: 96 DGTIKVWDVRSPSIPRNYKH-------NAPVNEVVIHPNQGELI---SCDRDGNIRI--- 142 DGT++VW++ + + + + +P+ I + + ++ + Sbjct: 458 DGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPI 517 Query: 143 --WDLGENQCTHQLTPEDDTSLQSLSMA-----------SDGSMLAAANT-KGNCYVWEM 188 +D+ N T + ++ + DG +A N K W Sbjct: 518 FGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNK 577 Query: 189 PNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADH---TARVWSIDDDFKLETT 245 P+ +T + + ++ + T D + + + Sbjct: 578 PSQKQLEKDICITI--SCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSP- 634 Query: 246 LDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 + + D F L S YVR++DLS + +V++ + + ++ Sbjct: 635 FKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHP 690 Score = 77.4 bits (189), Expect = 7e-15, Method: Composition-based stats. Identities = 49/312 (15%), Positives = 91/312 (29%), Gaps = 40/312 (12%) Query: 24 CSRTIQHSDSQVNRLEITNDKKLLATAGHQ-NVRLYDIRTTNPNPVASFEGHRGN----V 78 CS +V L I LAT VR+++I T + N + Sbjct: 429 CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHI 488 Query: 79 TSVSFQQD-NRWMVTSSEDGTIKV-------WDVRSP---SIPRNYKHNAPVNEVVIHPN 127 + + D N ++ + I + +D+ + I + ++ + Sbjct: 489 ECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLE 548 Query: 128 QGELISCDRDG-----------NIRIWDLGENQCTHQ---LTPEDDTSLQSLSMASDGSM 173 E D DG + W+ + + +T +++ LS G Sbjct: 549 VNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDY 608 Query: 174 LAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARV 233 + + P F+ I L CS R+ Sbjct: 609 FVTVQPDSGNTSVLIHQVSKHLTQSP---FKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRI 664 Query: 234 WSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW---DLSTREIVRQYGG 290 + + ++ L G RW+ L+ +S D V LW DL++ + Sbjct: 665 YDLSQQILVKKLLPG-ARWLSKIDIHPRGDNLIASSFDKRV-LWHDLDLAS-TPYKTLRY 721 Query: 291 HHKGAVCVALND 302 H K V + Sbjct: 722 HEKAVRSVNFHK 733 Score = 76.6 bits (187), Expect = 1e-14, Method: Composition-based stats. Identities = 39/219 (17%), Positives = 78/219 (35%), Gaps = 23/219 (10%) Query: 75 RGNVTSVSFQQDNRWMVTS---SEDGTIKVWDVRSPSIPRNYKHNAPV-NEVVIHPNQGE 130 + V +S+ + + VT S + ++ + V +K + + + HP + + Sbjct: 594 KKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQ 653 Query: 131 LISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPN 190 L C + +RI+DL + +L P L + + G L A++ ++ Sbjct: 654 LFVCSQ-RYVRIYDLSQQILVKKLLPGARW-LSKIDIHPRGDNLIASSFDKRVLWHDLDL 711 Query: 191 HTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSID--------DDFKL 242 + P R H + + + ++ + D T V+ Sbjct: 712 AST-----PYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVP 766 Query: 243 ETTLDGH----QRWVWDCAFSADSAYLVTASSDHYVRLW 277 L GH V D + A+L +A +D+ RLW Sbjct: 767 LKKLTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 805 Score = 70.1 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 27/156 (17%), Positives = 56/156 (35%), Gaps = 15/156 (9%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRT 62 L +R ++ + + + +++++I L + L+ Sbjct: 652 PQLFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLD 710 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWD-------VRSPSIP---RN 112 P + H V SV+F + ++++DGTI V+ +++P I + Sbjct: 711 LASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKL 770 Query: 113 YKHN----APVNEVVIHPNQGELISCDRDGNIRIWD 144 H V + + HP + L S D R+W Sbjct: 771 TGHKVINSLGVLDAIWHPREAWLFSAGADNTARLWT 806 >5A9Q-7 nrPDB Length = 360 Score = 93.2 bits (230), Expect = 1e-19, Method: Composition-based stats. Identities = 51/320 (15%), Positives = 111/320 (34%), Gaps = 55/320 (17%) Query: 31 SDSQVNRLEIT-NDKKLLATAGHQNVRLYD-IRTTNPNPVASFEGHRGNVTSVSFQQD-- 86 ++ + + +++ + Q+V+++D + + + AS++ H G+V V++ Sbjct: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70 Query: 87 NRWMVTSSEDGTIKVWDV---RSPSIPRNYKH----------NAPVNEVVIHPN--QGEL 131 + + + S D T VW+ S R H V +V P L Sbjct: 71 GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLML 130 Query: 132 ISCDRDGNIRIW------DLGENQCTHQLTPEDDTSLQSLSMASD---GSMLAAANTKGN 182 +C DG +RI+ +L + H+++ + S S + +S M+A + + Sbjct: 131 ATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSS 190 Query: 183 ----CYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVK----HLATCSADHTARVW 234 V + + + + I + ++ LA + D R++ Sbjct: 191 PNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKD--VRIF 248 Query: 235 SIDDDFK--------------LETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWD-- 278 ++ K + D H VW +++ L ++ D VRLW Sbjct: 249 TLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKAN 308 Query: 279 -LSTREIVRQYGGHHKGAVC 297 + + G+ Sbjct: 309 YMDNWKCTGILKGNGSPVNG 328 Score = 82.8 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 44/302 (14%), Positives = 103/302 (34%), Gaps = 51/302 (16%) Query: 5 LVSAGYDHTIRFWE---ALTGVCSRTIQHSDSQVNRLEITND--KKLLATAG-HQNVRLY 58 + + D +++ W+ + C+ + + V R+ + ++LA+ + ++ Sbjct: 27 MATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVLASCSFDRTAAVW 86 Query: 59 DIRTTNPNPVASFEGH----------RGNVTSVSFQQD--NRWMVTSSEDGTIKVW---- 102 + N + H R +VT V F + T S DG ++++ Sbjct: 87 EEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPD 146 Query: 103 --DVRSPSIPRNYKHNAPVNEVVIHP-----NQGELISCDRDGN------IRIWDLGENQ 149 ++ S+ + + +P + + D + ++I++ EN Sbjct: 147 VMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENT 206 Query: 150 CTHQLTPED---DTSLQSLSMASDG----SMLAAANTKGNCYVWEMPNHTDASHLKP--- 199 + + ++ A + +LA A + + S P Sbjct: 207 RKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKF 266 Query: 200 ----VTKFRAHSTYITRILLSSDVKHLATCSADHTARVW--SIDDDFKLETTLDGHQRWV 253 V +F H++ + R+ + LA+ D R+W + D++K L G+ V Sbjct: 267 EIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPV 326 Query: 254 WD 255 Sbjct: 327 NG 328 Score = 42.7 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 27/185 (14%), Positives = 62/185 (33%), Gaps = 41/185 (22%) Query: 1 MSVILVSAGYDHTIRFWEALTGVCSR--TIQHSDS---QVNRLEITND-----KKLLATA 50 M ++L + D +R +EA + ++QH S + + ++A Sbjct: 126 MGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVG 185 Query: 51 GHQN---------VRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDN----RWMVTSSEDG 97 + + Y+ T + V ++F + + +++D Sbjct: 186 SDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKD- 244 Query: 98 TIKVW-------DVRSPSIPRNYK---------HNAPVNEVVIHPNQGELISCDRDGNIR 141 ++++ ++ S P ++ HN+ V V + L S DG +R Sbjct: 245 -VRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVR 303 Query: 142 IWDLG 146 +W Sbjct: 304 LWKAN 308 Score = 28.1 bits (61), Expect = 4.7, Method: Composition-based stats. Identities = 11/37 (29%), Positives = 19/37 (51%), Gaps = 3/37 (8%) Query: 3 VILVSAGYDHTIRFWEA---LTGVCSRTIQHSDSQVN 36 +L S+G D +R W+A C+ ++ + S VN Sbjct: 291 TVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPVN 327 >6CB1-s nrPDB Length = 569 Score = 93.2 bits (230), Expect = 1e-19, Method: Composition-based stats. Identities = 52/334 (15%), Positives = 101/334 (30%), Gaps = 57/334 (17%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTI------QHSDSQVNRLEITNDKK--LLATAGHQNVR 56 L + D T+R WE LTG ++ D + +E D +LA A +N+ Sbjct: 214 LATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIH 273 Query: 57 L-------YDIRTTNPNPVASFEGHR--GNVTS--VSFQQDNRWMVTSSEDGT------- 98 L YDI + G+ G V + ++ EDG Sbjct: 274 LIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGD----GDEDGENESAKNA 329 Query: 99 ----IKVWDVRSPS-----IPRNYKHNAPVNEVVIHPNQGELISCDRD--GNIRIWDLGE 147 + W+ S I V ++ H ++ D + Sbjct: 330 VKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVS 389 Query: 148 NQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHS 207 T + + L + + ++++ S V K + Sbjct: 390 KHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRY-VRIYDL------SQQILVKKLLPGA 442 Query: 208 TYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVT 267 ++++I + +L S D +D TL H++ V F + Sbjct: 443 RWLSKIDIHPRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSS 502 Query: 268 ASSDHYVRLW------DLSTREI---VRQYGGHH 292 A+ D + ++ D+ + +++ GH Sbjct: 503 AADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHK 536 Score = 90.1 bits (222), Expect = 1e-18, Method: Composition-based stats. Identities = 34/213 (15%), Positives = 83/213 (38%), Gaps = 15/213 (7%) Query: 35 VNRLEITNDKKLLAT----AGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWM 90 V +L T +G+ +V ++ + + + F+ +G + F + Sbjct: 359 VKKLSWHRKGDYFVTVQPDSGNTSVLIH--QVSKHLTQSPFKKSKGIIMDAKFHPFKPQL 416 Query: 91 VTSSEDGTIKVWDVRSPSIPRNYKHNA-PVNEVVIHPNQGELISCDRDGNIRIWDLGENQ 149 S+ ++++D+ + + A ++++ IHP LI+ D + DL Sbjct: 417 FVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLAS 475 Query: 150 CTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVW---EMPNHTDASHLKPVTKFRAH 206 ++ + +++S++ + ++A G +V+ + + P+ K H Sbjct: 476 TPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGH 535 Query: 207 ----STYITRILLSSDVKHLATCSADHTARVWS 235 S + + L + AD+TAR+W+ Sbjct: 536 KVINSLGVLDAIWHPREAWLFSAGADNTARLWT 568 Score = 80.9 bits (198), Expect = 6e-16, Method: Composition-based stats. Identities = 45/297 (15%), Positives = 102/297 (34%), Gaps = 39/297 (13%) Query: 36 NRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSE 95 N+L I + + +++R + IR + GH+G V ++S W+ T S+ Sbjct: 165 NKLNIDPNSLIPELPSPKDLRPFPIR-----CSTIYAGHKGKVRTLSIDPSGLWLATGSD 219 Query: 96 DGTIKVWDVRSPSIPRNYKH-------NAPVNEVVIHPNQGELI---SCDRDGNIRI--- 142 DGT++VW++ + + + + +P+ I + + ++ + Sbjct: 220 DGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPI 279 Query: 143 --WDLGENQCTHQLTPEDDTSLQSLSMA-----------SDGSMLAAANT-KGNCYVWEM 188 +D+ N T + ++ + DG +A N K W Sbjct: 280 FGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNK 339 Query: 189 PNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADH---TARVWSIDDDFKLETT 245 P+ +T + + ++ + T D + + + Sbjct: 340 PSQKQLEKDICITI--SCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSP- 396 Query: 246 LDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 + + D F L S YVR++DLS + +V++ + + ++ Sbjct: 397 FKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHP 452 Score = 77.0 bits (188), Expect = 9e-15, Method: Composition-based stats. Identities = 49/312 (15%), Positives = 91/312 (29%), Gaps = 40/312 (12%) Query: 24 CSRTIQHSDSQVNRLEITNDKKLLATAGHQ-NVRLYDIRTTNPNPVASFEGHRGN----V 78 CS +V L I LAT VR+++I T + N + Sbjct: 191 CSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHI 250 Query: 79 TSVSFQQD-NRWMVTSSEDGTIKV-------WDVRSP---SIPRNYKHNAPVNEVVIHPN 127 + + D N ++ + I + +D+ + I + ++ + Sbjct: 251 ECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLE 310 Query: 128 QGELISCDRDG-----------NIRIWDLGENQCTHQ---LTPEDDTSLQSLSMASDGSM 173 E D DG + W+ + + +T +++ LS G Sbjct: 311 VNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDY 370 Query: 174 LAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARV 233 + + P F+ I L CS R+ Sbjct: 371 FVTVQPDSGNTSVLIHQVSKHLTQSP---FKKSKGIIMDAKFHPFKPQLFVCSQ-RYVRI 426 Query: 234 WSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW---DLSTREIVRQYGG 290 + + ++ L G RW+ L+ +S D V LW DL++ + Sbjct: 427 YDLSQQILVKKLLPG-ARWLSKIDIHPRGDNLIASSFDKRV-LWHDLDLAS-TPYKTLRY 483 Query: 291 HHKGAVCVALND 302 H K V + Sbjct: 484 HEKAVRSVNFHK 495 Score = 76.3 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 39/219 (17%), Positives = 78/219 (35%), Gaps = 23/219 (10%) Query: 75 RGNVTSVSFQQDNRWMVTS---SEDGTIKVWDVRSPSIPRNYKHNAPV-NEVVIHPNQGE 130 + V +S+ + + VT S + ++ + V +K + + + HP + + Sbjct: 356 KKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQ 415 Query: 131 LISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPN 190 L C + +RI+DL + +L P L + + G L A++ ++ Sbjct: 416 LFVCSQ-RYVRIYDLSQQILVKKLLPGARW-LSKIDIHPRGDNLIASSFDKRVLWHDLDL 473 Query: 191 HTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSID--------DDFKL 242 + P R H + + + ++ + D T V+ Sbjct: 474 AST-----PYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVP 528 Query: 243 ETTLDGH----QRWVWDCAFSADSAYLVTASSDHYVRLW 277 L GH V D + A+L +A +D+ RLW Sbjct: 529 LKKLTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLW 567 Score = 69.7 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 27/156 (17%), Positives = 56/156 (35%), Gaps = 15/156 (9%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRT 62 L +R ++ + + + +++++I L + L+ Sbjct: 414 PQLFVCSQ-RYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLD 472 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWD-------VRSPSIP---RN 112 P + H V SV+F + ++++DGTI V+ +++P I + Sbjct: 473 LASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKL 532 Query: 113 YKHN----APVNEVVIHPNQGELISCDRDGNIRIWD 144 H V + + HP + L S D R+W Sbjct: 533 TGHKVINSLGVLDAIWHPREAWLFSAGADNTARLWT 568 >6F1U-h nrPDB Length = 612 Score = 89.0 bits (219), Expect = 2e-18, Method: Composition-based stats. Identities = 55/287 (19%), Positives = 97/287 (33%), Gaps = 40/287 (13%) Query: 35 VNRLEITNDKKLLATAG-----------HQNVRLYDIRTTNPNPVASFEGHRGNVTSVSF 83 V+ L+ ++ L A +++++ P F + V S +F Sbjct: 256 VSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHC-QSAVMSATF 314 Query: 84 QQDNRWMVTSS-EDGTIKVWDVRSPS-------IPRNYKHNAPVNEVVI--HPNQGELIS 133 + + +V G I +WD RS H PV V + N LIS Sbjct: 315 AKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLIS 374 Query: 134 CDRDGNIRIWDL-----GENQCTHQLTPEDDTSLQSLSMA-SDGSMLAAANTKGNCYVWE 187 DG I W L ++ ++ S+S D + + +G+ Y Sbjct: 375 ISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYT-A 433 Query: 188 MPNHTDASHLKPVTKFRAHSTYITRILLSSD------VKHLATCSADHTARVWSIDDDFK 241 + + A + F H IT I + T S D T ++WS ++ Sbjct: 434 CRHGSKAGISE---MFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTKNNKP 490 Query: 242 LETTLDGHQRWVWDCAFSADSAYLVTASSD-HYVRLWDLSTREIVRQ 287 L + + + +V+D +S L + LW+L+ V Sbjct: 491 L-YSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPT 536 Score = 82.0 bits (201), Expect = 3e-16, Method: Composition-based stats. Identities = 40/298 (13%), Positives = 88/298 (29%), Gaps = 33/298 (11%) Query: 11 DHTIRFWEALTGVCSRTIQHS-DSQVNRLEITNDKKLLATAG--HQNVRLYDIRTTNPNP 67 D W + S V L G + L+D R+ P Sbjct: 284 DGVALVWNMKYKKTTPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTP 343 Query: 68 VA----SFEGHRGNVTSVSF--QQDNRWMVTSSEDGTIKVWDV---RSPSIPRNYKHN-- 116 V S H V V+ Q+ +++ S DG I W + P H Sbjct: 344 VQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQS 403 Query: 117 --APVNEVVI-HPNQGELISCDRDGNIRIW-DLGENQCTHQLTPEDDTSLQSLSMAS--- 169 V + + + +G++ G ++ + + + Sbjct: 404 KAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVG 463 Query: 170 ---DGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCS 226 + ++ +W N+ KP+ F ++ Y+ ++ S L C Sbjct: 464 AVDFSHLFVTSSFDWTVKLWSTKNN------KPLYSFEDNAGYVYDVMWSPTHPALFACV 517 Query: 227 AD-HTARVWSIDDDFKLETTLDGHQRWV--WDCAFSADSAYLVTASSDHYVRLWDLST 281 +W++++D ++ T + ++ + S+ + ++D+ Sbjct: 518 DGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGE 575 Score = 75.9 bits (185), Expect = 2e-14, Method: Composition-based stats. Identities = 39/272 (14%), Positives = 81/272 (29%), Gaps = 31/272 (11%) Query: 60 IRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSE----------DGTIKVWDVRSPSI 109 + + HR V+ + + ++ +S DG VW+++ Sbjct: 239 LSLNRQFFDERWSKHR-VVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKT 297 Query: 110 PRNYKH--NAPVNEVVIHPNQGELISCDR-DGNIRIWDLGENQCT-------HQLTPEDD 159 Y + V L+ G I +WD N+ T Sbjct: 298 TPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHP 357 Query: 160 TSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLS-SD 218 ++ + L + +T G W + + + ++ + +T + D Sbjct: 358 VYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGD 417 Query: 219 VKHLATCSADHTARVWSIDDDFK--LETTLDGHQRWVWDCAFSAD------SAYLVTASS 270 V + S + + + K + +GHQ + A S VT+S Sbjct: 418 VNNFVVGSEEGSVYT-ACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSF 476 Query: 271 DHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 D V+LW + + + + V + Sbjct: 477 DWTVKLWSTKNNKPLYSFEDNAGYVYDVMWSP 508 Score = 71.6 bits (174), Expect = 4e-13, Method: Composition-based stats. Identities = 34/267 (12%), Positives = 86/267 (32%), Gaps = 30/267 (11%) Query: 3 VILVSAGYDHTIRFWEALTGV---CSRTI---QHSDSQVNRLEIT---NDKKLLATAGHQ 53 ++V Y I W+ + RT V + + N L++ + Sbjct: 320 NLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDG 379 Query: 54 NVRLYDIR-TTNPNPVASFEGHRGN---VTSVSFQQDN-RWMVTSSEDGTIKVWDVRSPS 108 + + + ++P + VTS+SF + V SE+G++ R S Sbjct: 380 KICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVY-TACRHGS 438 Query: 109 IP----RNYKHNAPVNEVVIHPN------QGELISCDRDGNIRIWDLGENQCTHQLTPED 158 H P+ + H ++ D +++W N+ + ++ Sbjct: 439 KAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTKNNKPLYSFE-DN 497 Query: 159 DTSLQSLSMASDGS-MLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSS 217 + + + + A + G +W + N T+ + + R+ + Sbjct: 498 AGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNP---ALNRVRWTH 554 Query: 218 DVKHLATCSADHTARVWSIDDDFKLET 244 + +A ++ ++ + + + Sbjct: 555 SGREIAVGDSEGQIVIYDVGEQIAVPR 581 Score = 65.1 bits (157), Expect = 4e-11, Method: Composition-based stats. Identities = 18/106 (16%), Positives = 38/106 (35%), Gaps = 3/106 (2%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVR--LYD 59 S + V++ +D T++ W + + + V + + L R L++ Sbjct: 468 SHLFVTSSFDWTVKLWSTKNNKPLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWN 527 Query: 60 IRTTNPNPVASFEGHRGN-VTSVSFQQDNRWMVTSSEDGTIKVWDV 104 + P AS + V + R + +G I ++DV Sbjct: 528 LNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDV 573 >3ACP-A nrPDB Length = 417 Score = 88.2 bits (217), Expect = 4e-18, Method: Composition-based stats. Identities = 31/132 (23%), Positives = 53/132 (40%), Gaps = 10/132 (7%) Query: 172 SMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTA 231 T+G+ V + + +AH + IT++ + L + S D Sbjct: 107 RRFILGTTEGDIKVLDSNFNLQRE------IDQAHVSEITKLKFFPSGEALISSSQDMQL 160 Query: 232 RVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQY--- 288 ++WS+ D TL GH+ V D A +++AS D +RLW+ T + + Sbjct: 161 KIWSVKDGSN-PRTLIGHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNRK 219 Query: 289 GGHHKGAVCVAL 300 H G +AL Sbjct: 220 ENPHDGVNSIAL 231 Score = 82.4 bits (202), Expect = 2e-16, Method: Composition-based stats. Identities = 48/316 (15%), Positives = 121/316 (38%), Gaps = 47/316 (14%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKK-LLATAGHQNVRLYDIRTT 63 + + I+ ++ + Q S++ +L+ + L++++ ++++ ++ Sbjct: 109 FILGTTEGDIKVLDSNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDG 168 Query: 64 NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-----KHNAP 118 + + GHR VT ++ R ++++S DGTI++W+ + + + H+ Sbjct: 169 S--NPRTLIGHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDG- 225 Query: 119 VNEVVIHPN---------------------QGELISCDRDGNIRIWDLGENQCTHQLTPE 157 VN + + +I+ G I + ++ + T QL + Sbjct: 226 VNSIALFVGTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLPSK 285 Query: 158 DDTSLQSLSM-ASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLS 216 S SL++ ++ + + A G W++ + PV +F + + Sbjct: 286 FTCSCNSLTVDGNNANYIYAGYENGMLAQWDLRSPE-----CPVGEFLINEGTPINNVYF 340 Query: 217 SDVKHLATCSADHTARVWSIDD--------DFKLETTLDGHQRWVWD-CAFSADSAY--L 265 + + D + ++ I D +F+ T L + V C S D + + Sbjct: 341 AAGALFVSSGFDTSIKLDIISDPESERPAIEFETPTFLVSNDDEVSQFCYVSDDESNGEV 400 Query: 266 VTASSDHYVRLWDLST 281 + +++ L++LS Sbjct: 401 LEVGKNNFCALYNLSN 416 Score = 52.0 bits (123), Expect = 3e-07, Method: Composition-based stats. Identities = 20/132 (15%), Positives = 45/132 (34%), Gaps = 8/132 (6%) Query: 171 GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHT 230 GS L A G+ +++ + LK + + ++ + + Sbjct: 65 GSHLYKARLDGHDFLFNTIIRDGSKMLKRADYTAVDTAKL-------QMRRFILGTTEGD 117 Query: 231 ARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGG 290 +V + + + E H + F L+++S D +++W + R G Sbjct: 118 IKVLDSNFNLQREID-QAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTLIG 176 Query: 291 HHKGAVCVALND 302 H +A+ D Sbjct: 177 HRATVTDIAIID 188 >3JZG-A nrPDB Length = 402 Score = 88.2 bits (217), Expect = 4e-18, Method: Composition-based stats. Identities = 57/294 (19%), Positives = 102/294 (34%), Gaps = 34/294 (11%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKK--LLATAGHQNVRLYDI 60 +L AG IR +T C + + +N L+ LL+ + +RL++I Sbjct: 122 PLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNI 181 Query: 61 RTTNPNPV-ASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPV 119 +T + EGHR V S + +++ D ++K+W + S + K + Sbjct: 182 QTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDY 241 Query: 120 NEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANT 179 N + IS I D + + G ++ + + Sbjct: 242 NP---NKTNRPFIS----QKIHFPDFSTRDI-------HRNYVDCVRWL--GDLILSKSC 285 Query: 180 KGNCYVWEMPNHTD--------ASHLKPVTKFRAHSTYITRILLSSD--VKHLATCSADH 229 + W+ D S++ + +F I + S D K LA + Sbjct: 286 ENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVG 345 Query: 230 TARVWSI---DDDFKLETTLDGHQ--RWVWDCAFSADSAYLVTASSDHYVRLWD 278 VW + D TTL H+ + +FS DS+ L+ D + WD Sbjct: 346 KLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 399 Score = 68.6 bits (166), Expect = 3e-12, Method: Composition-based stats. Identities = 28/186 (15%), Positives = 72/186 (38%), Gaps = 21/186 (11%) Query: 115 HNAPVNEVVIHPNQ----GELISCDRDGNIRIWDLGENQCTH----QLTPEDDTSLQSLS 166 HN P+ V + + + + + +++ + + D + + + Sbjct: 53 HNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCA 112 Query: 167 MASDGS----MLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSS-DVKH 221 D + +LA A ++G + + ++ + + H I + D Sbjct: 113 WTYDSNTSHPLLAVAGSRGIIRI------INPITMQCIKHYVGHGNAINELKFHPRDPNL 166 Query: 222 LATCSADHTARVWSIDDDF--KLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDL 279 L + S DH R+W+I D + ++GH+ V + +++ DH ++LW + Sbjct: 167 LLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRI 226 Query: 280 STREIV 285 +++ ++ Sbjct: 227 NSKRMM 232 Score = 57.4 bits (137), Expect = 7e-09, Method: Composition-based stats. Identities = 28/166 (16%), Positives = 57/166 (34%), Gaps = 12/166 (7%) Query: 147 ENQCTHQLTPEDDTSLQSLSMASDG----SMLAAANTKGNCYVWEMPNHTDASHLKPVTK 202 +C + L + + L + ++ A ++E + + L+ Sbjct: 42 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVD 101 Query: 203 FRAHSTYITRIL-LSSDVKH--LATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFS 259 A + T S+ H LA + R+ + + GH + + F Sbjct: 102 ADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPIT-MQCIKHYVGHGNAINELKFH 160 Query: 260 A-DSAYLVTASSDHYVRLWDLSTREIVRQY---GGHHKGAVCVALN 301 D L++ S DH +RLW++ T +V + GH + + Sbjct: 161 PRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYD 206 Score = 29.7 bits (65), Expect = 1.7, Method: Composition-based stats. Identities = 24/128 (18%), Positives = 46/128 (35%), Gaps = 16/128 (12%) Query: 184 YVWEMPNHTDASHLKPVT--KFRAHS---TYITRILLSSDVKHLATCSADHTARVWSIDD 238 Y ++ N H +P+ +F HS + + S+ L C + R+ Sbjct: 41 YSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYV 100 Query: 239 DFKLETTLDGHQRWVWDCAFSADS----AYLVTASSDHYVRLWDLSTREIVRQYGGHHKG 294 D + + CA++ DS L A S +R+ + T + ++ Y GH Sbjct: 101 DADADENF-------YTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNA 153 Query: 295 AVCVALND 302 + + Sbjct: 154 INELKFHP 161 >4PSX-B nrPDB Length = 401 Score = 87.4 bits (215), Expect = 6e-18, Method: Composition-based stats. Identities = 34/251 (13%), Positives = 88/251 (35%), Gaps = 20/251 (7%) Query: 24 CSRTIQHSDSQVNRLEITN--DKKLLATAGHQNVRLYDIRTTN--PNPVASF-EGHRGNV 78 T++ L + +LL+ + V L+++ + PV ++ + H + Sbjct: 152 LQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDII 211 Query: 79 TSVSFQQ-DNRWMVTSSEDGTIKVWDVR-SPSIPRNYKHNAPVNEVVIHPNQ-GELISCD 135 + + T SED +K+ DVR + + K P N + + L + Sbjct: 212 NDNKWHNFNKDLFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAG 271 Query: 136 RDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMAS--DGSMLAAANTKGNCYVWEMPNHTD 193 D + ++DL + + ++ +L ++ DG ++++ + +W++ Sbjct: 272 MDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGS-DNRLMMWDLKQIGA 330 Query: 194 ASHL--------KPVTKFRAHSTYITRILLSSDVKHL-ATCSADHTARVWSIDDDFKLET 244 + + H + + L+ + L A+ ++ +VW + Sbjct: 331 EQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLPIVG 390 Query: 245 TLDGHQRWVWD 255 + + Sbjct: 391 GPPKVNKDIIS 401 Score = 76.6 bits (187), Expect = 1e-14, Method: Composition-based stats. Identities = 39/260 (15%), Positives = 83/260 (31%), Gaps = 33/260 (12%) Query: 68 VASFEGHRGNVTSVSFQQ-DNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIH 125 + + H +T + D + T + GT ++ RS + K H + Sbjct: 111 ITAKYEHEEEITRARYMPQDPNIVATINGQGTTFLYS-RSEGLQSTLKFHKDNGYALSFS 169 Query: 126 P-NQGELISCDRDGNIRIWDLGEN----QCTHQLTPEDDTSLQSLSMA-SDGSMLAAANT 179 +G L+S D + +W++G + + + + + Sbjct: 170 TLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSE 229 Query: 180 KGNCYVWEMP-NHTDASHLKPVTKFRAHSTYITRILLSS-DVKHLATCSADHTARVWSID 237 + ++ N+T +K + S LA D ++ + Sbjct: 230 DSLLKINDVRANNTTIDTVKC-------PQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLR 282 Query: 238 DDFKLETTLDGHQRWVWDCAFSAD-SAYLVTASSDHYVRLWDLST--------------R 282 + + + GH+ V + FS +V++ SD+ + +WDL Sbjct: 283 NMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVP 342 Query: 283 EIVRQYGGHHKGAVCVALND 302 E++ + GH LN Sbjct: 343 ELIMVHAGHRSSVNDFDLNP 362 Score = 57.8 bits (138), Expect = 5e-09, Method: Composition-based stats. Identities = 21/121 (17%), Positives = 45/121 (37%), Gaps = 16/121 (13%) Query: 2 SVILVSAGYDHTIRFWEALTGV-CSRTIQHSDSQVNRLEITN--DKKLLATAGHQNVRLY 58 S +L +AG D + ++ + + VN LE + D ++++ + ++ Sbjct: 264 SNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMW 323 Query: 59 DI------------RTTNPNPVASFEGHRGNVTSVSFQQDNRWMV-TSSEDGTIKVWDVR 105 D+ P + GHR +V W+V ++ E+ ++VW Sbjct: 324 DLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCS 383 Query: 106 S 106 Sbjct: 384 H 384 >5YZG-2 nrPDB Length = 646 Score = 87.4 bits (215), Expect = 7e-18, Method: Composition-based stats. Identities = 40/235 (17%), Positives = 88/235 (37%), Gaps = 23/235 (9%) Query: 74 HRGNVTSVSFQQDNRWMVTSSEDGTIKVWD--VRSPSIPRNYK-HNAPVNEVVIHPNQGE 130 HR +T V + + +++T+S DG +K W ++++ H + + + Sbjct: 89 HRDVITHVVCTKTD-FIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSSEGAL 147 Query: 131 LISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMAS-DGSMLAAANTKGNCYVWEMP 189 S D ++++D+ + L D AA+ K ++ Sbjct: 148 FCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYCPGDAISSVAASEKSTGKIFIYD 207 Query: 190 NHTDASHLKPVTKFRA-HSTYITRILLSSDVKHLATCSADHTARVWSIDD---------D 239 D +P+ F H++ +T+I L+ K + + W+ + Sbjct: 208 GRGD---NQPLHIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFPKNVN 264 Query: 240 FKLETTLDGHQ-----RWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYG 289 ++ +T D ++ + FS D + T SD VR++ T +++R + Sbjct: 265 WEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIATIGSDRKVRIFRFVTGKLMRVFD 319 Score = 80.9 bits (198), Expect = 6e-16, Method: Composition-based stats. Identities = 39/232 (16%), Positives = 77/232 (33%), Gaps = 16/232 (6%) Query: 31 SDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWM 90 + + T ++ + +V+ + V F H G + S++ + Sbjct: 89 HRDVITHVVCTKTDFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSSEGALF 148 Query: 91 VTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELIS---CDRDGNIRIWDL-- 145 + +D +KV+DV + + K + G+ IS +I+ Sbjct: 149 CSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYCPGDAISSVAASEKSTGKIFIYDG 208 Query: 146 -GENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNH---------TDAS 195 G+NQ H + L + + + +++ G W P H + Sbjct: 209 RGDNQPLHIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFPKNVNWEYK 268 Query: 196 HLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLD 247 + +F Y T + S D K +AT +D R++ KL D Sbjct: 269 TDTDLYEFAKCKAYPTSVCFSPDGKKIATIGSDRKVRIFRFVTG-KLMRVFD 319 Score = 68.2 bits (165), Expect = 4e-12, Method: Composition-based stats. Identities = 27/211 (12%), Positives = 76/211 (36%), Gaps = 34/211 (16%) Query: 4 ILVSAGYDHTIRFWEA--LTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQN-VRLYDI 60 +++A +D ++FW+ + + + + ++++ L + G ++++D+ Sbjct: 103 FIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSSEGALFCSVGDDKAMKVFDV 162 Query: 61 ---RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSED----GTIKVWDVRSPSIPRNY 113 N + F G + + + + G I ++D R + P + Sbjct: 163 VNFDMINMLKLGYFPGQCEWIYC-----PGDAISSVAASEKSTGKIFIYDGRGDNQPLHI 217 Query: 114 ---KHNAPVNEVVIHPNQGELISCDRDGNIRI---------------WDLGENQCTHQLT 155 H +P+ ++ ++P ++S D+ G I W+ + ++ Sbjct: 218 FDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFPKNVNWEYKTDTDLYEFA 277 Query: 156 PEDDTSLQSLSMASDGSMLAAANTKGNCYVW 186 S+ + DG +A + ++ Sbjct: 278 KCKAYP-TSVCFSPDGKKIATIGSDRKVRIF 307 >6IYY-A nrPDB Length = 317 Score = 86.7 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 46/246 (18%), Positives = 86/246 (34%), Gaps = 20/246 (8%) Query: 40 ITNDKKLLATAGHQNVRLYDIRT-TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGT 98 D A R+Y+ EG G+V + + N + Sbjct: 15 FNQDHGCFACGMENGFRVYNTDPLKEKEKQEFLEGGVGHVEML--FRCNYLALVGGGKKK 72 Query: 99 IKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPED 158 + +WD + + V V + ++ I D I+++ N HQL + Sbjct: 73 VMIWDDLKKKTVIEIEFSTEVKAVKLRRDR---IVVVLDSMIKVFTFTHN--PHQLHVFE 127 Query: 159 DTS----LQSLSMASDGSMLA-AANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRI 213 L L S+ S+LA G+ + ++ AS KP AH ++ I Sbjct: 128 TCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDL-----ASTEKPPVDIPAHEGVLSCI 182 Query: 214 LLSSDVKHLATCSADHT-ARVWSIDDDFKLETTLDGHQRW-VWDCAFSADSAYLVTASSD 271 L+ +AT S T R++ ++ G Q ++ F+ D++ + +S Sbjct: 183 ALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRGSQAANIYCINFNQDASLICVSSDH 242 Query: 272 HYVRLW 277 V ++ Sbjct: 243 GTVHIF 248 >2P9P-C nrPDB Length = 372 Score = 86.7 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 36/246 (14%), Positives = 79/246 (32%), Gaps = 23/246 (9%) Query: 76 GNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK---HNAPVNEVVIHPNQGELI 132 ++ ++ +D + + + +++ + ++ HN V V P+ ++ Sbjct: 9 EPISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIV 68 Query: 133 SCDRDGNIRIWDLGENQCTHQL-TPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNH 191 +C D N +W L L + + + + A + A + + Sbjct: 69 TCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQE 128 Query: 192 TDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI---DDDFKLETTLDG 248 D K + + + + + + LA S D R++S + + + T G Sbjct: 129 NDWWVCKHIK--KPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWG 186 Query: 249 HQ--------------RWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKG 294 + WV FSA+ + + S D V L D + V Sbjct: 187 SKMPFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTVCLADADKKMAVATLASETLP 246 Query: 295 AVCVAL 300 + V Sbjct: 247 LLAVTF 252 Score = 84.0 bits (206), Expect = 8e-17, Method: Composition-based stats. Identities = 41/254 (16%), Positives = 85/254 (33%), Gaps = 20/254 (7%) Query: 34 QVNRLEITNDKKLLATAGHQN-VRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVT 92 ++ D+ +A + + V +Y+ V + H G VT V + D+ +VT Sbjct: 10 PISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIVT 69 Query: 93 SSEDGTIKVWDVRSPSI---PRNYKHNAPVNEVVIHPNQGELISCDRDG--NIRIWDLGE 147 D VW ++ + + N V PN+ + +I ++ Sbjct: 70 CGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQEN 129 Query: 148 NQCT-HQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEM--------PNHTDASHLK 198 + + +++ SL + +LAA + C ++ P T Sbjct: 130 DWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKM 189 Query: 199 PVTKFRAHS----TYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVW 254 P + S ++ + S++ +A S D T + D + TL + Sbjct: 190 PFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTVCLADADKKMAV-ATLASETLPLL 248 Query: 255 DCAFSADSAYLVTA 268 F +S+ + Sbjct: 249 AVTFITESSLVAAG 262 Score = 65.5 bits (158), Expect = 3e-11, Method: Composition-based stats. Identities = 28/228 (12%), Positives = 66/228 (28%), Gaps = 29/228 (12%) Query: 21 TGVCSRTIQHSDSQVNRLEITNDKK-LLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVT 79 V ++ + QV ++ D ++ +N ++ ++ P Sbjct: 41 KWVQVHELKEHNGQVTGVDWAPDSNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAAR 100 Query: 80 SVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKH-----NAPVNEVVIHPNQGELISC 134 V + + + S I + + KH + V + HPN L + Sbjct: 101 CVRWAPNEKKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAG 160 Query: 135 DRDGNIRIWDLGENQCTHQLTPEDDTS-----------------LQSLSMASDGSMLAAA 177 D RI+ + + P S + + +++GS +A Sbjct: 161 SCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSANGSRVAWV 220 Query: 178 NTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATC 225 + + DA V + + + + ++ +A Sbjct: 221 SHDSTVCL------ADADKKMAVATLASETLPLLAVTFITESSLVAAG 262 Score = 36.2 bits (82), Expect = 0.017, Method: Composition-based stats. Identities = 31/251 (12%), Positives = 60/251 (23%), Gaps = 39/251 (15%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIR 61 SV+L + D R + A + ++ + +L+ + Sbjct: 154 SVLLAAGSCDFKCRIFSAY----IKEVEERPAPTPWGSKMPFGELMFESSSSC------- 202 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNA-PVN 120 G V V F + + S D T+ + D P+ Sbjct: 203 --------------GWVHGVCFSANGSRVAWVSHDSTVCLADADKKMAVATLASETLPLL 248 Query: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 V + L++ D ++ D QS Sbjct: 249 AVTFI-TESSLVAAGHDCFPVLFTYDSAAGKLSFGGRLDVPKQSSQRGLTAR-------- 299 Query: 181 GNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVK----HLATCSADHTARVWSI 236 + ++ S H +++I + S K T D +W + Sbjct: 300 ERFQNLDKKASSEGSAAAGAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDV 359 Query: 237 DDDFKLETTLD 247 L Sbjct: 360 RSLESALKDLK 370 >5LTD-A nrPDB Length = 525 Score = 86.7 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 57/282 (20%), Positives = 108/282 (38%), Gaps = 28/282 (9%) Query: 35 VNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSS 94 +N D ++ ++Y+ + +G G V + F +V Sbjct: 34 INFANFNQDFSCVSVGYSNGYKIYNCEPF-GQCYSKSDGSIGIVEML-FSSSLLAIVGMG 91 Query: 95 EDGTI-----KVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQ 149 E ++ K+ + + + + V ++ + ++ + I I+D+ + Sbjct: 92 EQHSLSPRRLKIINTKRQTTICELTFPGAILAVKLNRERLVVL---LEETIYIYDINNMR 148 Query: 150 CTHQL-TPEDDTSLQSLSMASDGSMLA-------AANTKGNCYVWEMPNHT--------D 193 H + TP + L +LS +S+ + LA A N + + P D Sbjct: 149 LLHTIETPSNPNGLIALSPSSENNYLAYPSPQKLAPNPQTEVTLHSNPQTVRNGDVIIFD 208 Query: 194 ASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTA-RVWSIDDDFKLETTLDG-HQR 251 A L+P + AH T + I LS D LAT S T RV+S+ KL G + Sbjct: 209 AKTLQPTSVIEAHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQFRRGTYPT 268 Query: 252 WVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHK 293 ++ AFS D+ +++ +S+ V ++ L E +K Sbjct: 269 KIYSLAFSPDNRFVIASSATETVHIFRLGEEEAANTIKSANK 310 Score = 60.9 bits (146), Expect = 6e-10, Method: Composition-based stats. Identities = 45/266 (16%), Positives = 98/266 (36%), Gaps = 44/266 (16%) Query: 6 VSAGYDHTIRFWEALT-GVCSRTIQHSDSQVNRLEITNDKKLLATAGHQN------VRLY 58 VS GY + + + G C S V L ++ + G Q+ +++ Sbjct: 46 VSVGYSNGYKIYNCEPFGQCYSKSDGSIGIVEML-FSSSLLAIVGMGEQHSLSPRRLKII 104 Query: 59 DIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAP 118 + + +F G + +V ++ ++ + TI ++D+ + + + + Sbjct: 105 NTKRQTTICELTFPG---AILAVKLNRERLVVLL---EETIYIYDINNMRLLHTIETPSN 158 Query: 119 VNE-VVIHP--NQGELISCD---------------------RDGNIRIWDLGENQCTHQL 154 N + + P L R+G++ I+D Q T + Sbjct: 159 PNGLIALSPSSENNYLAYPSPQKLAPNPQTEVTLHSNPQTVRNGDVIIFDAKTLQPTSVI 218 Query: 155 TPEDDTSLQSLSMASDGSMLAAANTKGNC-YVWEMPNHTDASHLKPVTKFRAHSTYITRI 213 TSL +++++ DG +LA A+ KG V+ + + T + T I + Sbjct: 219 EAHR-TSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQFRRGT----YPTKIYSL 273 Query: 214 LLSSDVKHLATCSADHTARVWSIDDD 239 S D + + SA T ++ + ++ Sbjct: 274 AFSPDNRFVIASSATETVHIFRLGEE 299 Score = 60.1 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 20/107 (18%), Positives = 47/107 (43%), Gaps = 2/107 (1%) Query: 10 YDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQN--VRLYDIRTTNPNP 67 + + ++A T + I+ + + + ++ D LLATA + +R++ + T Sbjct: 200 RNGDVIIFDAKTLQPTSVIEAHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLY 259 Query: 68 VASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK 114 + + S++F DNR+++ SS T+ ++ + K Sbjct: 260 QFRRGTYPTKIYSLAFSPDNRFVIASSATETVHIFRLGEEEAANTIK 306 >3F3P-A nrPDB Length = 351 Score = 85.9 bits (211), Expect = 2e-17, Method: Composition-based stats. Identities = 45/313 (14%), Positives = 109/313 (34%), Gaps = 45/313 (14%) Query: 5 LVSAGYDHTIRFW----EALTGVCSRTIQHSDSQVNRLEITND--KKLLATAG-HQNVRL 57 + + D I+ + + S + + DS + ++ + +++A+A + V+L Sbjct: 26 VATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKL 85 Query: 58 YDIRTTNP-------NPVASFEGHRGNVTSVSFQQD--NRWMVTSSEDGTIKVWDVRSPS 108 ++ N + + +G++ SV F + DG ++++D PS Sbjct: 86 WEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLGNDGILRLYDALEPS 145 Query: 109 IPRNYKHNAPVN--------------EVVIHPN--QGELISCDRDGNIRIWDLGENQCTH 152 R++ + + + P+ E ++ I+ G++ H Sbjct: 146 DLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLH 205 Query: 153 Q--LTPEDDTSLQSLSMASD----GSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAH 206 P + ++S+S A ++A G ++++ + Sbjct: 206 VAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNM 265 Query: 207 STYITRILLSSDVKHLATCSADHTARVWSIDDDFKLET--TLDGHQRWVWDCAFSADSAY 264 + + + + S +T + + ++E D H VW +++ Sbjct: 266 FDNSADVDMDAQGR-----SDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTI 320 Query: 265 LVTASSDHYVRLW 277 L +A D VRLW Sbjct: 321 LSSAGDDGKVRLW 333 Score = 70.5 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 42/244 (17%), Positives = 89/244 (36%), Gaps = 34/244 (13%) Query: 72 EGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW----DVRSPSIPRNYK-HNAPVNEVVI-H 125 GH V V + R + T S D IKV+ D + + +++ H++ + + Sbjct: 8 SGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVAIDWAS 67 Query: 126 PNQGELI-SCDRDGNIRIW--DLGENQCTHQ------LTPEDDTSLQSLSMASD--GSML 174 P G +I S D +++W D + +C+ + + SL S+ A G L Sbjct: 68 PEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKL 127 Query: 175 AAANTKGNCYVWEMPNHTDASHLKPVTKFR-------AHSTYITRILLSSDV---KHLAT 224 A G +++ +D ++ + H + + LA Sbjct: 128 ACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAV 187 Query: 225 CSADHTARVWSIDDDFKLE--TTLDGHQRWVWDCAFSAD----SAYLVTASSDHYVRLWD 278 + + ++ D KL L GH+ + +++ + T D +R++ Sbjct: 188 SALEQAI-IYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRIFK 246 Query: 279 LSTR 282 ++ + Sbjct: 247 ITEK 250 Score = 68.6 bits (166), Expect = 3e-12, Method: Composition-based stats. Identities = 43/290 (14%), Positives = 96/290 (33%), Gaps = 52/290 (17%) Query: 3 VILVSAGYDHTIRFWEALTGV---------CSRTIQHSDSQVNRLEITND--KKLLATAG 51 I+ SA YD T++ WE T+ S + ++ LA G Sbjct: 72 RIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAHLGLKLACLG 131 Query: 52 HQNV------------RLYDIRTTNPNPVASFEGHRGNVTSVSFQQD----NRWMVTS-- 93 + + R + + + H + +S+ + V++ Sbjct: 132 NDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRFSPEKLAVSALE 191 Query: 94 -------SEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHP----NQGELISCDRDGNIRI 142 +DG + V + H + + + P + + +DG IRI Sbjct: 192 QAIIYQRGKDGKLHV-------AAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDGRIRI 244 Query: 143 WDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTK 202 + + E + + + E T+ ++D M A + N E ++ +++ Sbjct: 245 FKITE-KLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTE--EKAELQSNLQVELLSE 301 Query: 203 FRAHSTYITRILLSSDVKHLATCSADHTARVW--SIDDDFKLETTLDGHQ 250 H+ + + + L++ D R+W + ++FK + + Q Sbjct: 302 HDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYSNEFKCMSVITAQQ 351 Score = 56.2 bits (134), Expect = 1e-08, Method: Composition-based stats. Identities = 26/140 (18%), Positives = 53/140 (37%), Gaps = 14/140 (10%) Query: 151 THQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYI 210 D + + G +A ++ + V+++ D S+ + +RAH + I Sbjct: 3 MQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDK--DTSNWELSDSWRAHDSSI 60 Query: 211 TRILL--SSDVKHLATCSADHTARVWSIDDD--------FKLETTLDGHQRWVWDCAFSA 260 I + +A+ S D T ++W D D + TL+ + ++ F+ Sbjct: 61 VAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAP 120 Query: 261 D--SAYLVTASSDHYVRLWD 278 L +D +RL+D Sbjct: 121 AHLGLKLACLGNDGILRLYD 140 >5WLC-LN nrPDB Length = 776 Score = 84.4 bits (207), Expect = 6e-17, Method: Composition-based stats. Identities = 42/275 (15%), Positives = 96/275 (34%), Gaps = 14/275 (5%) Query: 12 HTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASF 71 H RF + + S +N+L + D +L + N+ +++ R + Sbjct: 34 HRCRFVDFTPATITSLAFSHKSNINKLTPS-DLRLAIGRSNGNIEIWNPRNNWFQEMVIE 92 Query: 72 EGHRGNVTSVSFQQ---DNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPV-NEVVIHPN 127 G ++ + + ++ + + + WD+ + RNY N+ V + I+ + Sbjct: 93 GGKDRSIEGLCWSNVNGESLRLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISINDS 152 Query: 128 QGELISCDRDGNIRIWDLGENQCTH---QLTPEDDTSLQSLSMASDGSMLAAANTKGNCY 184 Q +L +G + + D+ + + + +L+ D + + G Sbjct: 153 QDKLSVGCDNGTVVLIDISGGPGVLEHDTILMRQEARVLTLAWKKD-DFVIGGCSDGRIR 211 Query: 185 VW----EMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDF 240 +W N H V K + ST + ++ +A+ + + + W Sbjct: 212 IWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFWDFQFAT 271 Query: 241 KLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVR 275 L + H V D+ Y+ +A D + Sbjct: 272 -LNQSFKAHDADVLCLTTDTDNNYVFSAGVDRKIF 305 Score = 80.9 bits (198), Expect = 7e-16, Method: Composition-based stats. Identities = 46/303 (15%), Positives = 100/303 (33%), Gaps = 42/303 (13%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTI--QHSDSQVNRLEITNDK----KLLATAGHQNVRLY 58 L + I W + D + L +N +L + G V + Sbjct: 67 LAIGRSNGNIEIWNPRNNWFQEMVIEGGKDRSIEGLCWSNVNGESLRLFSIGGSTVVTEW 126 Query: 59 DIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKH--- 115 D+ T P+ +++ + G + S+S + ++GT+ + D+ P +H Sbjct: 127 DLATG--LPLRNYDCNSGVIWSISINDSQDKLSVGCDNGTVVLIDISGG--PGVLEHDTI 182 Query: 116 ----NAPVNEVVIHPNQGELISCDRDGNIRIW-----DLGENQCTHQLTPEDDTSLQSLS 166 A V + + + C DG IRIW D + H + + +L Sbjct: 183 LMRQEARVLTLAWKKDDFVIGGCS-DGRIRIWSAQKNDENMGRLLHTMKVDKAKKESTLV 241 Query: 167 MA----SDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHL 222 + +A+ ++ G+ W+ T F+AH + + +D ++ Sbjct: 242 WSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQS------FKAHDADVLCLTTDTDNNYV 295 Query: 223 ATCSADHTARVWSIDDDFKLETTLDG-------HQRWVWDCAF--SADSAYLVTASSDHY 273 + D +S + + + H + S + +LV+ + Sbjct: 296 FSAGVDRKIFQFSQNTNKSQKNNRWVNSSNRLLHGNDIRAICAYQSKGADFLVSGGVEKT 355 Query: 274 VRL 276 + + Sbjct: 356 LVI 358 Score = 80.1 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 30/243 (12%), Positives = 74/243 (30%), Gaps = 21/243 (8%) Query: 74 HRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRS---PSIPRNYKHNAPVNEVVIHPNQGE 130 H+ N+ ++ + + +G I++W+ R+ + + + + GE Sbjct: 53 HKSNINKLT--PSDLRLAIGRSNGNIEIWNPRNNWFQEMVIEGGKDRSIEGLCWSNVNGE 110 Query: 131 ---LISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWE 187 L S + WDL + + S+S+ L+ G + + Sbjct: 111 SLRLFSIGGSTVVTEWDLATGLPLRNYD-CNSGVIWSISINDSQDKLSVGCDNGTVVLID 169 Query: 188 MPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTL- 246 + + + + D + +D R+WS + + L Sbjct: 170 ISGGPGVLEHDTI--LMRQEARVLTLAWKKD-DFVIGGCSDGRIRIWSAQKNDENMGRLL 226 Query: 247 --------DGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCV 298 VW + + + + S ++ WD + + + H +C+ Sbjct: 227 HTMKVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAHDADVLCL 286 Query: 299 ALN 301 + Sbjct: 287 TTD 289 Score = 74.7 bits (182), Expect = 4e-14, Method: Composition-based stats. Identities = 50/313 (15%), Positives = 110/313 (35%), Gaps = 41/313 (13%) Query: 4 ILVSAGYDHTIRFWEALT-----GVCSRTI-----QHSDSQVNRLEITNDKKLLATAGH- 52 ++ D IR W A G T+ + + V + +A+ Sbjct: 200 FVIGGCSDGRIRIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDST 259 Query: 53 QNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPR- 111 +++ +D + N SF+ H +V ++ DN ++ ++ D I + + + Sbjct: 260 GSIKFWDFQFATLN--QSFKAHDADVLCLTTDTDNNYVFSAGVDRKIFQFSQNTNKSQKN 317 Query: 112 --------NYKHNAPVNEVVIHPNQGE--LISCDRDGNIRIWDLGENQCTHQLT-PEDDT 160 H + + + ++G L+S + + I L + P + Sbjct: 318 NRWVNSSNRLLHGNDIRAICAYQSKGADFLVSGGVEKTLVINSLTSFSNGNYRKMPTVEP 377 Query: 161 SLQSLSMASDGSMLAAANTKGNCYVWEM-PNHTDASHLKPVTKFR-AHSTYITRILLSSD 218 +++ + + ++ + + +W M + + + K V K I+ LS D Sbjct: 378 YSKNVLVNKEQRLVVSWSE-STVKIWTMGTDSSTEQNYKLVCKLTLKDDQNISTCSLSPD 436 Query: 219 VKHLATCSADHTARVWSIDD-DFKLETT-------LDGHQRWVWDCAFSADSAYLVTASS 270 + L T +V+ + KL+ T L + V F +S ++ + Sbjct: 437 GQVLVVG-RPSTTKVFHLQPVGNKLKVTKLDNDLLLRTSTKLV---KFIDNSKIVICSCE 492 Query: 271 DHYVRLWDLSTRE 283 D V + DL + E Sbjct: 493 DD-VFIVDLESEE 504 Score = 41.2 bits (95), Expect = 6e-04, Method: Composition-based stats. Identities = 20/101 (19%), Positives = 43/101 (42%), Gaps = 6/101 (5%) Query: 206 HSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDG-HQRWVWDCAFS---AD 261 H + I ++ + LA ++ +W+ +++ E ++G R + +S + Sbjct: 53 HKSNINKL--TPSDLRLAIGRSNGNIEIWNPRNNWFQEMVIEGGKDRSIEGLCWSNVNGE 110 Query: 262 SAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 S L + V WDL+T +R Y + +++ND Sbjct: 111 SLRLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISIND 151 >5CXB-B nrPDB Length = 369 Score = 84.4 bits (207), Expect = 6e-17, Method: Composition-based stats. Identities = 58/346 (16%), Positives = 110/346 (31%), Gaps = 86/346 (24%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQ-HSDSQVNRLEITNDKK--LLATAGHQNVRLY--- 58 L + G D T+R WE LTG +++ + D VN + K +LA A +++ L Sbjct: 36 LATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNTVRWRPTKDTFILAAAAGEDIFLMIPT 95 Query: 59 ------DIRTTNPNPVASFEGH-------------------------------------- 74 + + + + + GH Sbjct: 96 HPSVTPALDQASRDILNAGFGHATNGKQQANLPPGKEPPGKWARPGTRLEDEGVLLRITV 155 Query: 75 RGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY-KHNAPV---------NEVVI 124 R + ++S+ + T S G RS KH + Sbjct: 156 RSTIKAISWHRRGDHFATVSPSGQ------RSSVAIHTLSKHLTQIPFRKLNGLAQTASF 209 Query: 125 HPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCY 184 HP + + +IR +DL + + + P + S + G L + Sbjct: 210 HPLRPLFFVATQ-RSIRCYDLQKLELVKIVQPGAKW-ISSFDVHPGGDNLVVGSYDKRL- 266 Query: 185 VWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDV-KHLATCSADHTARVW-------SI 236 +W + ++ +P R H+ I + A S D + +++ + Sbjct: 267 LWHDLDLSN----RPYKTMRFHTEAIRAVRFHKGGLPLFADASDDGSLQIFHGKVPNDQL 322 Query: 237 DDDFKL-ETTLDGHQR----WVWDCAFSADSAYLVTASSDHYVRLW 277 ++ + L GH+ V D + + V+A +D RLW Sbjct: 323 ENPTIVPVKMLKGHKVVNKLGVLDIDWHPREPWCVSAGADGTARLW 368 Score = 80.5 bits (197), Expect = 8e-16, Method: Composition-based stats. Identities = 43/298 (14%), Positives = 80/298 (26%), Gaps = 61/298 (20%) Query: 59 DIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNA- 117 +++ F GH G V SV+ + T +DGT++VW++ + + K N Sbjct: 5 ELKPFPTVQQTIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGD 64 Query: 118 -PVNEVVIHPNQGELI---SCDRDGNIRI---------WDLGENQCTHQLTPEDDTS--- 161 VN V P + I + D + I D + Sbjct: 65 EAVNTVRWRPTKDTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNGKQQ 124 Query: 162 ----------------------------------LQSLSMASDGSMLAAANTKGNCYVWE 187 ++++S G A + G Sbjct: 125 ANLPPGKEPPGKWARPGTRLEDEGVLLRITVRSTIKAISWHRRGDHFATVSPSGQRSSVA 184 Query: 188 MPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLD 247 + + P K + + + + R + + ++ Sbjct: 185 IHTLSKHLTQIPFRKLNGLAQTAS---FHPLRPLFFVATQ-RSIRCYDLQKLELVKIVQP 240 Query: 248 GHQRWVWDCAFSADSAYLVTASSDHYVRLW---DLSTREIVRQYGGHHKGAVCVALND 302 G +W+ LV S D + LW DLS + H + V + Sbjct: 241 G-AKWISSFDVHPGGDNLVVGSYDKRL-LWHDLDLSN-RPYKTMRFHTEAIRAVRFHK 295 Score = 71.3 bits (173), Expect = 5e-13, Method: Composition-based stats. Identities = 39/329 (11%), Positives = 85/329 (25%), Gaps = 72/329 (21%) Query: 28 IQHSDSQVNRLEITNDKKLLATAGHQ-NVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQD 86 + + +V + I LAT G VR++++ T G V +V ++ Sbjct: 17 FRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNG-DEAVNTVRWRPT 75 Query: 87 NRWMV---TSSEDGTIKV------------------------------------------ 101 + + ED + + Sbjct: 76 KDTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNGKQQANLPPGKEPPG 135 Query: 102 -W-----DVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLT 155 W + + + + + H + G + Sbjct: 136 KWARPGTRLEDEGVLLRITVRSTIKAISWHRRGDHFATVSPSGQRSSVAIHTLSKHLTQI 195 Query: 156 PEDDTSL--QSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRI 213 P + Q+ S + A + + +++ L+ V + + +I+ Sbjct: 196 PFRKLNGLAQTASFHPLRPLFFVATQR-SIRCYDLQK------LELVKIVQPGAKWISSF 248 Query: 214 LLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADS-AYLVTASSDH 272 + +L S D +D + T+ H + F AS D Sbjct: 249 DVHPGGDNLVVGSYDKRLLWHDLDLSNRPYKTMRFHTEAIRAVRFHKGGLPLFADASDDG 308 Query: 273 YVRLW-------DLSTREI--VRQYGGHH 292 ++++ L I V+ GH Sbjct: 309 SLQIFHGKVPNDQLENPTIVPVKMLKGHK 337 Score = 68.2 bits (165), Expect = 5e-12, Method: Composition-based stats. Identities = 25/159 (15%), Positives = 60/159 (37%), Gaps = 18/159 (11%) Query: 1 MSVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLY-D 59 + + A +IR ++ + +Q ++ ++ L + L+ D Sbjct: 212 LRPLFFVATQ-RSIRCYDLQKLELVKIVQPGAKWISSFDVHPGGDNLVVGSYDKRLLWHD 270 Query: 60 IRTTNPNPVASFEGHRGNVTSVSFQQDN-RWMVTSSEDGTIKVWD-------VRSPSIP- 110 + +N P + H + +V F + +S+DG+++++ + +P+I Sbjct: 271 LDLSN-RPYKTMRFHTEAIRAVRFHKGGLPLFADASDDGSLQIFHGKVPNDQLENPTIVP 329 Query: 111 ------RNYKHNAPVNEVVIHPNQGELISCDRDGNIRIW 143 + V ++ HP + +S DG R+W Sbjct: 330 VKMLKGHKVVNKLGVLDIDWHPREPWCVSAGADGTARLW 368 >3I2N-A nrPDB Length = 357 Score = 83.2 bits (204), Expect = 1e-16, Method: Composition-based stats. Identities = 52/310 (16%), Positives = 109/310 (35%), Gaps = 50/310 (16%) Query: 12 HTIRFWEALTG--VCSRTIQHSDSQVNRLEI---TNDKKLLATAG-HQNVRLYDIRTTNP 65 I+ +E G R I+ + + + ++ LAT N+ ++++ Sbjct: 44 GVIQLYEIQHGDLKLLREIEKAK-PIKCGTFGATSLQQRYLATGDFGGNLHIWNLEAPEM 102 Query: 66 NPVASFEGHRGNVTSVSFQQD------NRWMVTSSEDGTIKVWDVRSPS------IPRNY 113 PV S +GH+ + ++ +VT S DGT+KVWD R P Sbjct: 103 -PVYSVKGHKEIINAIDGIGGLGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQG 161 Query: 114 KHNAPVNEVVI----HPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMAS 169 ++ V + + + + +G+I+++DL + ++ + SL Sbjct: 162 ENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRNMALRWETNIKNG--VCSLEFDR 219 Query: 170 ---DGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILL-SSDVKHLATC 225 + L A + +G +V++M V++ +AH + + ++ + + T Sbjct: 220 KDISMNKLVATSLEGKFHVFDMRTQHPTKGFASVSE-KAHKSTVWQVRHLPQNRELFLTA 278 Query: 226 SADHTARVWSID------------------DDFKLETTLDGHQRWVWDCAFSADSAYLVT 267 +W + L + + + +S D L Sbjct: 279 GGAGGLHLWKYEYPIQRSKKDSEGIEMGVAGSVSLLQNVTLSTQPISSLDWSPDKRGLCV 338 Query: 268 ASS-DHYVRL 276 SS D VR+ Sbjct: 339 CSSFDQTVRV 348 Score = 76.6 bits (187), Expect = 1e-14, Method: Composition-based stats. Identities = 40/278 (14%), Positives = 94/278 (33%), Gaps = 39/278 (14%) Query: 3 VILVSAGYDHTIRFWEALTGV-CSRTIQHSDSQVNRLEITND-------KKLLATAGHQN 54 L + + + W +++ +N ++ +++ + Sbjct: 81 RYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPEIVTGSRDGT 140 Query: 55 VRLYDIRTTNPNPVASFEGHRGN----VTSVSF----QQDNRWMVTSSEDGTIKVWDVRS 106 V+++D R + +PVA+ E +G +V+F Q+ R + ++G IK++D+R+ Sbjct: 141 VKVWDPRQKD-DPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLFDLRN 199 Query: 107 PSIPRNYKHNAPVNEVVIHPNQ---GELISCDRDGNIRIWDLGENQCTHQL-----TPED 158 ++ V + +L++ +G ++D+ T Sbjct: 200 MALRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPTKGFASVSEKAHK 259 Query: 159 DTSLQSLSMASDGSMLAAANTKGNCYVWEMP-------------NHTDASHLKPVTKFRA 205 T Q + + + A G ++W+ A + + Sbjct: 260 STVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRSKKDSEGIEMGVAGSVSLLQNVTL 319 Query: 206 HSTYITRILLSSDVK-HLATCSADHTARVWSIDDDFKL 242 + I+ + S D + S D T RV + K+ Sbjct: 320 STQPISSLDWSPDKRGLCVCSSFDQTVRVLIVTKLNKI 357 Score = 68.9 bits (167), Expect = 2e-12, Method: Composition-based stats. Identities = 29/189 (15%), Positives = 59/189 (31%), Gaps = 26/189 (13%) Query: 114 KHNAPVNEVVIHPNQGELISCDR----DGNIRIWDLGENQCTHQLTPEDDTSLQSLSMAS 169 N V + P + ++ G I+++++ E ++ + + Sbjct: 16 GFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEKAKPIKCGTFGA 75 Query: 170 DG---SMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVK------ 220 LA + GN ++W + PV + H I I + Sbjct: 76 TSLQQRYLATGDFGGNLHIWNLEAPEM-----PVYSVKGHKEIINAIDGIGGLGIGEGAP 130 Query: 221 HLATCSADHTARVWSIDDDFKLETTLDGHQRW----VWDCAF----SADSAYLVTASSDH 272 + T S D T +VW ++ Q W AF + + + + Sbjct: 131 EIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNG 190 Query: 273 YVRLWDLST 281 ++L+DL Sbjct: 191 DIKLFDLRN 199 Score = 42.0 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 14/76 (18%), Positives = 30/76 (39%), Gaps = 6/76 (7%) Query: 214 LLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSAD------SAYLVT 267 S ++LAT +W+++ ++ GH+ + + +VT Sbjct: 75 ATSLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPEIVT 134 Query: 268 ASSDHYVRLWDLSTRE 283 S D V++WD ++ Sbjct: 135 GSRDGTVKVWDPRQKD 150 >5K19-A nrPDB Length = 569 Score = 83.2 bits (204), Expect = 1e-16, Method: Composition-based stats. Identities = 28/199 (14%), Positives = 68/199 (34%), Gaps = 13/199 (6%) Query: 31 SDSQVNRLEITNDKKLLAT-AGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRW 89 + +N + D K LA + +R+++ + + + + + G + V + D ++ Sbjct: 219 GEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELH--GTMKSYFGGLLCVCWSPDGKY 276 Query: 90 MVTSSEDGTIKVWDVRSPSIP-RNYKHNAPVNEVVIHPNQGEL-------ISCDRDGNIR 141 +VT ED + VW + R + H + V+ V P + S + Sbjct: 277 IVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGSDEDFQD 336 Query: 142 IWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVT 201 + G ++ + + S + +W++ H +P++ Sbjct: 337 LLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTEDILFPH-QPLS 395 Query: 202 KFRAHSTYITRILLSSDVK 220 + R H+ + Sbjct: 396 RARTHTN-VMNATSPPAGS 413 Score = 79.3 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 37/199 (18%), Positives = 70/199 (35%), Gaps = 27/199 (13%) Query: 130 ELISCDRDGNIRIWDLGENQCTHQLTPE---DDTSLQSLSMAS-DGSMLAAANTKGNCYV 185 L+ G +++ D + + + E D + + + S+ A++ GN Y+ Sbjct: 117 SLLVGFSAGQVQLIDPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYL 176 Query: 186 WEMPNH----------------------TDASHLKPVTKFRAHSTYITRILLSSDVKHLA 223 + + + S P+ K+ + S D K LA Sbjct: 177 YNVEHTCGTTAPHYQLLKQGESFAVHTCKSKSTRNPLLKWTVGEGALNEFAFSPDGKFLA 236 Query: 224 TCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTRE 283 S D RV++ D +L T+ + + +S D Y+VT D V +W Sbjct: 237 CVSQDGFLRVFNFDS-VELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFVDCR 295 Query: 284 IVRQYGGHHKGAVCVALND 302 ++ + GH VA + Sbjct: 296 VIARGHGHKSWVSVVAFDP 314 Score = 60.1 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 29/255 (11%), Positives = 81/255 (31%), Gaps = 49/255 (19%) Query: 33 SQVNRLEITN--DKKLLATAGHQNVRLYDIRT--------------------------TN 64 S+V ++ + L N+ LY++ + Sbjct: 150 SRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKST 209 Query: 65 PNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVV 123 NP+ + G + +F D +++ S+DG ++V++ S + K + + V Sbjct: 210 RNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVC 269 Query: 124 IHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMAS--------DGSMLA 175 P+ +++ D + +W + + + + + ++ D + Sbjct: 270 WSPDGKYIVTGGEDDLVTVWSFVDCRVIARGHGHK-SWVSVVAFDPYTTSVEEGDPMEFS 328 Query: 176 AANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWS 235 ++ + + +++ + + S ++ + D +W Sbjct: 329 GSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSV------TYRFGSVGQDTQLCLWD 382 Query: 236 IDDDFKLETTLDGHQ 250 + +D L HQ Sbjct: 383 LTED-----ILFPHQ 392 Score = 54.3 bits (129), Expect = 6e-08, Method: Composition-based stats. Identities = 24/163 (14%), Positives = 50/163 (30%), Gaps = 28/163 (17%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRT 62 L D +R + + T++ + + + D K + T G V ++ Sbjct: 234 FLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSF-- 291 Query: 63 TNPNPVASFEGHRGNVTSVSFQQ-------DNRWMVTSSEDGTIKVWDVRSPSIPRNYKH 115 + +A GH+ V+ V+F + + S D + + Sbjct: 292 VDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFSGS--------DEDFQDLLHFGRD 343 Query: 116 NAPVNEVVIHPNQGE----------LISCDRDGNIRIWDLGEN 148 A + + S +D + +WDL E+ Sbjct: 344 RANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTED 386 >4G56-B nrPDB Length = 357 Score = 81.7 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 38/236 (16%), Positives = 87/236 (36%), Gaps = 14/236 (5%) Query: 75 RGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPR-----NYKHNAPVNEVVIHPNQG 129 VT V++ + + ++ +S+ G +++W++ Y+H+ V + + + Sbjct: 94 EAGVTDVAWVSE-KGILVASDSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSDGT 152 Query: 130 ELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMP 189 + +S +D ++++WDL + + ++ + G +W+ Sbjct: 153 QAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTR 212 Query: 190 NHTDASHLKPVTKFRAHSTYITRILLSSD-VKHLATCSADHTARVWSIDDDFKLETTLDG 248 A+ + F A T T + + A + +I + + T Sbjct: 213 KPKPATRID----FCASDTIPTSVTWHPEKDDTFACGDETGNVSLVNIKNPDSAQ-TSAV 267 Query: 249 HQRWVWDCAFS-ADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALNDV 303 H + + A+S S +L + S D V + D E+ R H VA + + Sbjct: 268 HSQNITGLAYSYHSSPFLASISEDCTVAVLDADFSEVFRDLS-HRDFVTGVAWSPL 322 Score = 78.6 bits (192), Expect = 3e-15, Method: Composition-based stats. Identities = 31/160 (19%), Positives = 57/160 (35%), Gaps = 4/160 (2%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQ--HSDSQVNRLEITNDKKLLATAGHQNVRLYDI 60 I +S G D I W+ + I SD+ + +K G + + + Sbjct: 195 TIFLSCGEDGRILLWDTRKPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLV 254 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQ-QDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPV 119 NP+ + H N+T +++ + ++ + SED T+ V D + R+ H V Sbjct: 255 NIKNPDSAQTSAVHSQNITGLAYSYHSSPFLASISEDCTVAVLDADFSEVFRDLSHRDFV 314 Query: 120 NEVVIHP-NQGELISCDRDGNIRIWDLGENQCTHQLTPED 158 V P + + + D + L T L Sbjct: 315 TGVAWSPLDHSKFTTVGWDHKVLHHHLPSEGRTENLIATK 354 Score = 71.6 bits (174), Expect = 4e-13, Method: Composition-based stats. Identities = 31/200 (15%), Positives = 70/200 (35%), Gaps = 8/200 (4%) Query: 6 VSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLE--ITNDKKLLATAGHQNVRLYDIRTT 63 VS G D +++ W+ ++ S+VN + D L+ + L+D R Sbjct: 155 VSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTRKP 214 Query: 64 NPNPVASFEGHRGNVTSVSFQQD-NRWMVTSSEDGTIKVWDVRSP-SIPRNYKHNAPVNE 121 P F TSV++ + + E G + + ++++P S + H+ + Sbjct: 215 KPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLVNIKNPDSAQTSAVHSQNITG 274 Query: 122 VVIHPNQGELI-SCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMAS-DGSMLAAANT 179 + + + S D + + D ++ L+ + ++ + D S Sbjct: 275 LAYSYHSSPFLASISEDCTVAVLDADFSEVFRDLS--HRDFVTGVAWSPLDHSKFTTVGW 332 Query: 180 KGNCYVWEMPNHTDASHLKP 199 +P+ +L Sbjct: 333 DHKVLHHHLPSEGRTENLIA 352 Score = 30.8 bits (68), Expect = 0.71, Method: Composition-based stats. Identities = 14/66 (21%), Positives = 22/66 (33%), Gaps = 2/66 (3%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITN-DKKLLATAGHQNVRLYDI 60 S L S D T+ +A R + H D V + + D T G + L+ Sbjct: 282 SPFLASISEDCTVAVLDADFSEVFRDLSHRD-FVTGVAWSPLDHSKFTTVGWDHKVLHHH 340 Query: 61 RTTNPN 66 + Sbjct: 341 LPSEGR 346 >1PI6-A nrPDB Length = 615 Score = 80.5 bits (197), Expect = 8e-16, Method: Composition-based stats. Identities = 54/361 (14%), Positives = 123/361 (34%), Gaps = 95/361 (26%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSR--TIQHSD--SQVNRLEITNDKKLLATAGHQNVRL 57 S + G D TIR W+ T C + T+ +Q + T + ++++ + + Sbjct: 264 SQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLDGTLNF 323 Query: 58 YDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRS----------- 106 Y++ + + + GH +T+++ +++ S DG I W S Sbjct: 324 YEL--GHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQDHSNLIVS 377 Query: 107 --PSIPRNYKHNAP-----VNEVVIH--PNQGELISCDRDG------------------- 138 S + Y + VN + H +Q ++ S + DG Sbjct: 378 LDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTG 437 Query: 139 ------------------------------NIRIWDLGENQCTHQLTPEDDTSLQSLSMA 168 I+++ L + + + L +S++ Sbjct: 438 DIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISIS 497 Query: 169 SDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVK-------- 220 + +AA + G ++++ + + ++ I I K Sbjct: 498 PSETYIAAGDVMGKILLYDLQSREVKTSRWAFR-----TSKINAISWKPAEKGANEEEIE 552 Query: 221 --HLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWD 278 +AT S D ++S+ K+ L+ H+ V + + + LV++ +D ++ W+ Sbjct: 553 EDLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLW-ETPSTLVSSGADACIKRWN 611 Query: 279 L 279 + Sbjct: 612 V 612 Score = 78.2 bits (191), Expect = 4e-15, Method: Composition-based stats. Identities = 45/299 (15%), Positives = 102/299 (34%), Gaps = 29/299 (9%) Query: 2 SVILVSAGYDHTIRFW--------EALTGVCSRTIQHSDSQVNRLEITNDKK--LLATAG 51 S L S + W ++ Q ++ + + + + G Sbjct: 78 SQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVVGEG 137 Query: 52 HQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNR-WMVTSSEDGTIKVWDVR----S 106 N ++ I + N + GH + + +Q +T +DG++ + S Sbjct: 138 RDNFGVF-ISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFS 196 Query: 107 PSIPRNYKHNAPVNEVVIHPNQGEL-ISCDRDGNIRIWDLGENQCTHQLTPEDDT---SL 162 S ++K + V +V P+ GE I+ D I +D + + + + + Sbjct: 197 ASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGI 256 Query: 163 QSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHL 222 +LS D A VW++ + + ++ + + + + Sbjct: 257 FALSW-LDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQV--GVVATGNGR-I 312 Query: 223 ATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLST 281 + S D T + + D ++ T+ GH + + + L++ S D + W S+ Sbjct: 313 ISLSLDGTLNFYELGHD-EVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSSS 366 Score = 76.3 bits (186), Expect = 1e-14, Method: Composition-based stats. Identities = 49/341 (14%), Positives = 102/341 (29%), Gaps = 71/341 (20%) Query: 29 QHSDSQVNRLEITNDKKLLA--TAGHQNVRLYDIRTTNPNPVASFEGH-RGNVTSVSFQQ 85 + L +A VR D + PV F GH VT+V F Sbjct: 15 STQRNFTTHLSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVKFSP 74 Query: 86 --DNRWMVTSSEDGTIKVW----DVRSPSIPRNYKHN-----APVNEVVIHPNQGELISC 134 ++++ + E G + VW D S S+ N K P++++ L Sbjct: 75 IKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRLCVV 134 Query: 135 DR--DGNIRIWDLGENQCTHQLTPEDD-TSLQSLSMASDGSMLAAANTKGNCYVWEMPNH 191 D +++ + L + + + G+ ++ P Sbjct: 135 GEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGD-DGSVVFYQGPPF 193 Query: 192 TDASHLKPVTKFRAHSTYITRILLSSD-VKHLATCSADHTARVWSIDDDFKLETT---LD 247 ++ + +++ + S D + + T +D + L+ + Sbjct: 194 KFSASDR---THHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQE 250 Query: 248 GHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVR--------------------- 286 Q ++ ++ DS T +D +R+WD++T + V+ Sbjct: 251 PVQGGIFALSWL-DSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGN 309 Query: 287 ------------------------QYGGHHKGAVCVALNDV 303 GH+KG + +N + Sbjct: 310 GRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPL 350 >5BJS-A nrPDB Length = 605 Score = 79.3 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 28/164 (17%), Positives = 63/164 (38%), Gaps = 21/164 (12%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLL--ATAGHQNVRLYDI 60 +L AG + ++ + G RT+ +N L + + + + +R++ + Sbjct: 149 PLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIWSL 208 Query: 61 RTTNPN----PVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVR----------- 105 + + EGH ++ SV+F + R+++++ D I +W + Sbjct: 209 APEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPEFPNEHMEIPI 268 Query: 106 ---SPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLG 146 P + HN V+ V + + +C D I +W + Sbjct: 269 VIYYPHFSSSEIHNNLVDCVAFYGDLILSRACHED-TIVLWRIE 311 Score = 77.4 bits (189), Expect = 7e-15, Method: Composition-based stats. Identities = 35/182 (19%), Positives = 71/182 (39%), Gaps = 24/182 (13%) Query: 33 SQVNRLEITNDKKLLATAGH-QNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMV 91 + + D+ LL AG+ NV++Y++ T + GH G + ++ N +++ Sbjct: 137 ASCWSKDPITDQPLLCIAGNEGNVKVYNV--TEGKLYRTLVGHGGGINDLATSPANPYII 194 Query: 92 -TSSEDGTIKVWDVRSP-------SIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIW 143 ++S+D TI++W + I H+ + V H N ++S D I +W Sbjct: 195 ASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLW 254 Query: 144 DLGENQCTHQLTP------------EDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNH 191 L E H P + + ++ D +L+ A + +W + Sbjct: 255 ALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAFYGD-LILSRACHEDTIVLWRIEGF 313 Query: 192 TD 193 + Sbjct: 314 SS 315 Score = 76.3 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 22/168 (13%), Positives = 62/168 (36%), Gaps = 17/168 (10%) Query: 127 NQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSML-AAANTKGNCYV 185 +Q L +GN++++++ E + L + L+ + + A+A+ + Sbjct: 147 DQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGG-GINDLATSPANPYIIASASDDTTIRI 205 Query: 186 WEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDD------- 238 W + + + HS + + + +++ + D +W++ + Sbjct: 206 WSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPEFPNEHME 265 Query: 239 -----DFKLETTLDGHQRWVWDCAFSADSAYLVT-ASSDHYVRLWDLS 280 + ++ + H V AF D +++ A + + LW + Sbjct: 266 IPIVIYYPHFSSSEIHNNLVDCVAFYGD--LILSRACHEDTIVLWRIE 311 Score = 38.9 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 10/51 (19%), Positives = 22/51 (43%) Query: 252 WVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 W D L A ++ V++++++ ++ R GH G +A + Sbjct: 138 SCWSKDPITDQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSP 188 >5AMS-A nrPDB Length = 431 Score = 77.4 bits (189), Expect = 6e-15, Method: Composition-based stats. Identities = 50/323 (15%), Positives = 101/323 (31%), Gaps = 33/323 (10%) Query: 3 VILVSAGYDHTIRFWEALTG--VCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDI 60 ++ + G D+ W + + + T+ V T++ L TA L + Sbjct: 78 PLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSEGGFLVTADMSGKVLVHM 137 Query: 61 --RTTNPNPVASFEGHRGNVTSVSFQQD-NRWMVTSSEDGTIKVWDVRSP-----SIPRN 112 + +AS + + R + DG++ + + + Sbjct: 138 GQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSG 197 Query: 113 YKHNAPVNEVVIHP-----NQGELISCDRDGNIRIWDLGENQCTHQLTPED----DTSLQ 163 + H + N EL++C D I W+ Q ++T + + Sbjct: 198 FVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWI 257 Query: 164 SLSMASDGS------MLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTY----ITRI 213 SLS+A + ++A + G V N HL V + + I I Sbjct: 258 SLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLSTVIELKPEQDELDASIESI 317 Query: 214 LLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHY 273 SS +A ++ +++ + V F D L + + Sbjct: 318 SWSSKFSLMAIGLVCGEILLYD-TSAWRVRHKFVL-EDSVTKLMFDNDD--LFASCINGK 373 Query: 274 VRLWDLSTREIVRQYGGHHKGAV 296 V ++ T + GH+ G + Sbjct: 374 VYQFNARTGQEKFVCVGHNMGVL 396 Score = 61.6 bits (148), Expect = 4e-10, Method: Composition-based stats. Identities = 39/197 (19%), Positives = 69/197 (35%), Gaps = 13/197 (6%) Query: 103 DVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIW--DLGENQCTHQLTPEDDT 160 D+ + S+ KH V + HPN + + D +W + LT + Sbjct: 52 DMSNNSLTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGE- 110 Query: 161 SLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVK 220 S+ S S S+G L A+ G V + K ++ + + + + Sbjct: 111 SVISCSFTSEGGFLVTADMSGKVLVHMGQKGG--AQWKLASQMQEVEEIVWLKTHPTIAR 168 Query: 221 HLATCSADHTARVWSI-DDDFKLETTLDG--HQRWVWDCAFSADSA-----YLVTASSDH 272 A + D + + I + D LE + G HQ+ F LVT S D Sbjct: 169 TFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDS 228 Query: 273 YVRLWDLSTREIVRQYG 289 + W+ T + + + Sbjct: 229 TIVAWNCFTGQQLFKIT 245 Score = 44.7 bits (104), Expect = 5e-05, Method: Composition-based stats. Identities = 32/213 (15%), Positives = 66/213 (30%), Gaps = 29/213 (13%) Query: 5 LVSAGYDHTIRFWEALTGVCS-----RTIQHSDSQVNRLEITND-----KKLLATAGHQN 54 LV+ D TI W TG I+ ++ L + + + G N Sbjct: 221 LVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNN 280 Query: 55 VRLYDIRTTNPNPVASFEGH----------RGNVTSVSFQQDNRWMVTSSEDGTIKVWDV 104 L I N + ++ S+S+ M G I ++D Sbjct: 281 GLLAVINCNNGGAILHLSTVIELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYDT 340 Query: 105 RSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQS 164 + + + V +++ + +L + +G + ++ Q + L Sbjct: 341 SAWRVRHKFVLEDSVTKLMF--DNDDLFASCINGKVYQFNARTGQEKFVCVGHNMGVLDF 398 Query: 165 LSMAS-------DGSMLAAANTKGNCYVWEMPN 190 + + + A +G V+E+PN Sbjct: 399 ILLHPVANTGTEQKRKVITAGDEGVSLVFEVPN 431 >3DWL-C nrPDB Length = 377 Score = 73.6 bits (179), Expect = 9e-14, Method: Composition-based stats. Identities = 37/250 (14%), Positives = 73/250 (29%), Gaps = 21/250 (8%) Query: 41 TNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIK 100 + + + T V LY+ +F H VT V + + +VT S+D Sbjct: 21 SQRTEFVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSNRIVTCSQDRNAY 80 Query: 101 VW----DVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDL---GENQCTHQ 153 V+ D + N V PN+ + I + + + Sbjct: 81 VYEKRPDGTWKQTLVLLRLNRAATFVRWSPNEDKFAVGSGARVISVCYFEQENDWWVSKH 140 Query: 154 LTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASH-----------LKPVTK 202 L +++ SL + +LAA YV + V Sbjct: 141 LKRPLRSTILSLDWHPNNVLLAAGCADRKAYVLSAYVRDVDAKPEASVWGSRLPFNTVCA 200 Query: 203 FRAHSTYITRILLSSDVKHLATCSADHTARVW---SIDDDFKLETTLDGHQRWVWDCAFS 259 ++ + S LA D + + + + + T+ Q + ++ Sbjct: 201 EYPSGGWVHAVGFSPSGNALAYAGHDSSVTIAYPSAPEQPPRALITVKLSQLPLRSLLWA 260 Query: 260 ADSAYLVTAS 269 +SA + Sbjct: 261 NESAIVAAGY 270 Score = 66.6 bits (161), Expect = 1e-11, Method: Composition-based stats. Identities = 39/216 (18%), Positives = 71/216 (32%), Gaps = 23/216 (10%) Query: 82 SFQQDNRWMVTSSEDGTIKVW--DVRSPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDG 138 +F VT++ ++++ D R + H+ V V P +++C +D Sbjct: 18 AFNSQRTEFVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSNRIVTCSQDR 77 Query: 139 NIRIWDLGENQCTHQ--LTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASH 196 N +++ + Q + + + + + + A + V D Sbjct: 78 NAYVYEKRPDGTWKQTLVLLRLNRAATFVRWSPNEDKFAVGSGARVISVCYFEQENDWWV 137 Query: 197 LKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSI---DDDFKLETTLDGHQ--- 250 K + R + I + + LA AD A V S D D K E ++ G + Sbjct: 138 SKHLK--RPLRSTILSLDWHPNNVLLAAGCADRKAYVLSAYVRDVDAKPEASVWGSRLPF 195 Query: 251 ----------RWVWDCAFSADSAYLVTASSDHYVRL 276 WV FS L A D V + Sbjct: 196 NTVCAEYPSGGWVHAVGFSPSGNALAYAGHDSSVTI 231 Score = 53.9 bits (128), Expect = 9e-08, Method: Composition-based stats. Identities = 27/246 (10%), Positives = 67/246 (27%), Gaps = 27/246 (10%) Query: 5 LVSAGYDHTIRFW--EALTGVCSRTIQHSDSQVNRLEITNDKK-LLATAGHQNVRLYDIR 61 V+ + + + + +RT D V ++ ++ + +N +Y+ R Sbjct: 26 FVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSNRIVTCSQDRNAYVYEKR 85 Query: 62 TTNPNPVASFEGHRGNVTS-VSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKH----- 115 + V + + S I V + KH Sbjct: 86 PDGTWKQTLVLLRLNRAATFVRWSPNEDKFAVGSGARVISVCYFEQENDWWVSKHLKRPL 145 Query: 116 NAPVNEVVIHPNQGELISCDRDGNIRIWDLG--------ENQCTHQLTPEDDTS------ 161 + + + HPN L + D + E P + Sbjct: 146 RSTILSLDWHPNNVLLAAGCADRKAYVLSAYVRDVDAKPEASVWGSRLPFNTVCAEYPSG 205 Query: 162 --LQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDV 219 + ++ + G+ LA A + + + + + + +L +++ Sbjct: 206 GWVHAVGFSPSGNALAYAGHDSSVTI--AYPSAPEQPPRALITVKLSQLPLRSLLWANES 263 Query: 220 KHLATC 225 +A Sbjct: 264 AIVAAG 269 Score = 40.8 bits (94), Expect = 7e-04, Method: Composition-based stats. Identities = 13/68 (19%), Positives = 27/68 (39%), Gaps = 1/68 (1%) Query: 214 LLSSDVKHLATCSADHTARVWSID-DDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDH 272 +S T +A + ++ D + +K T H + V ++ S +VT S D Sbjct: 18 AFNSQRTEFVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSNRIVTCSQDR 77 Query: 273 YVRLWDLS 280 +++ Sbjct: 78 NAYVYEKR 85 >3JB9-S nrPDB Length = 488 Score = 70.5 bits (171), Expect = 9e-13, Method: Composition-based stats. Identities = 34/181 (18%), Positives = 74/181 (40%), Gaps = 6/181 (3%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTT 63 L++A + + + V + T+ + L + D L AG +N L T+ Sbjct: 309 YLLAAS-NEKCYIFSLKSQVYNITVAQH---ITSLAVHPDGNLFV-AGLENGELRFFETS 363 Query: 64 NPNPVASFEGHRGNVTSVSFQQDNRWM-VTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEV 122 + N + F H V ++ F ++ W+ VT+++D I +WD+R + + V V Sbjct: 364 SGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKSELVQKIPLQTKVAAV 423 Query: 123 VIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGN 182 + L+S D + + ++ ++ +S+ +L ++ L + + G Sbjct: 424 SLDITSQLLVSSDGETLYVHIYVKSSKSWRCMSQTHVSSISNLVWLNELHQLLFSTSNGA 483 Query: 183 C 183 Sbjct: 484 I 484 Score = 64.3 bits (155), Expect = 7e-11, Method: Composition-based stats. Identities = 39/224 (17%), Positives = 84/224 (37%), Gaps = 24/224 (10%) Query: 85 QDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWD 144 +++ +++ +D + + D++S S + ++ +A ++ D I I++ Sbjct: 220 ENSSFVLCLHKDELLCL-DIQSNSTLKIFEGSA--LACCWL-TSSKIAVATAD-AISIFE 274 Query: 145 LGENQCTHQLTPEDDTSLQS------LSMASDGSMLAAANTKGNCYVWEMPNHTDASHLK 198 + Q E +S+ L G L AA+ CY++ + + + Sbjct: 275 FPVSSSGLQSVGEPTSSIPIDEKVNFLQAHPSGEYLLAAS-NEKCYIFSLKSQVYNITV- 332 Query: 199 PVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAF 258 + +IT + + D + R + +L T H V F Sbjct: 333 --------AQHITSLAVHPDGNLFVAGLENGELRFFETSSGNEL-TKFGPHSSPVKTLQF 383 Query: 259 SADSAYLV-TASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALN 301 + +LV T + D + +WDL E+V++ K V+L+ Sbjct: 384 GENGYWLVVTTNDDSDIFIWDLRKSELVQKIPLQTK-VAAVSLD 426 Score = 45.1 bits (105), Expect = 3e-05, Method: Composition-based stats. Identities = 24/142 (16%), Positives = 56/142 (39%), Gaps = 7/142 (4%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLL--ATAGHQNVRLYDI 60 + V+ + +RF+E +G S V L+ + L T ++ ++D+ Sbjct: 346 NLFVAGLENGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDL 405 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGT-IKVWDVRSPSIP-RNYKHNAP 118 R + + V +VS ++ +V+S + + ++ S S + H + Sbjct: 406 RKSELVQKIPLQT---KVAAVSLDITSQLLVSSDGETLYVHIYVKSSKSWRCMSQTHVSS 462 Query: 119 VNEVVIHPNQGELISCDRDGNI 140 ++ +V +L+ +G I Sbjct: 463 ISNLVWLNELHQLLFSTSNGAI 484 >5MC6-j nrPDB Length = 397 Score = 68.9 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 40/317 (12%), Positives = 91/317 (28%), Gaps = 37/317 (11%) Query: 6 VSAGYDHTIRFWE------------ALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQ 53 VS D ++ W+ + + ++ H + +E + L Sbjct: 30 VSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHVDVLQAIERDAFELCLVATTSF 89 Query: 54 NVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY 113 + L R T + + ++ ++ + W + W + + + Sbjct: 90 SGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFWALK---------WGASNDRLLSHR 140 Query: 114 KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSM 173 V + E Q T + S+ ++ G + Sbjct: 141 LVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPSQFATSVDISERG-L 199 Query: 174 LAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHT--- 230 +A G + E+ + + +S I + S LA ++ Sbjct: 200 IATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSLLAIAHDSNSFGC 259 Query: 231 ARVWSIDDDFKL----------ETTL--DGHQRWVWDCAFSADSAYLVTASSDHYVRLWD 278 ++ + ++ + +L H WV +F+ L +A D +R WD Sbjct: 260 ITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGETLCSAGWDGKLRFWD 319 Query: 279 LSTREIVRQYGGHHKGA 295 + T+E + H Sbjct: 320 VKTKERITTLNMHCDDI 336 Score = 29.7 bits (65), Expect = 1.5, Method: Composition-based stats. Identities = 10/31 (32%), Positives = 15/31 (48%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQV 35 L SAG+D +RFW+ T T+ + Sbjct: 306 LCSAGWDGKLRFWDVKTKERITTLNMHCDDI 336 >5WLC-LW nrPDB Length = 554 Score = 68.6 bits (166), Expect = 3e-12, Method: Composition-based stats. Identities = 32/220 (14%), Positives = 81/220 (36%), Gaps = 18/220 (8%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATA-GHQNVRLYDIRT 62 +LV+AG +++ + TG ++ + ++ + V L+ Sbjct: 204 LLVTAGETGWLKYHDVSTGQLVSELRTKAGPTMAMAQNPWNAVMHLGHSNGTVSLWS--P 261 Query: 63 TNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEV 122 + P P+ RG V S++ + +M T+ D ++K+WD+R+ + + + P Sbjct: 262 SMPEPLVKLLSARGPVNSIAIDRSGYYMATTGADRSMKIWDIRNFKQLHSVE-SLPTPGT 320 Query: 123 VIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSL--SMASDGSMLAAANTK 180 + + L++ R ++ +W + +L+ + S+ + + ++ Sbjct: 321 NVSISDTGLLALSRGPHVTLW-----KDALKLSGDSKPCFGSMGGNPHRNTPYMSHLFAG 375 Query: 181 GNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVK 220 D + H T IT +++ + Sbjct: 376 NKVENLGFVPFEDLLGV-------GHQTGITNLIVPGAGE 408 Score = 66.2 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 39/263 (14%), Positives = 94/263 (35%), Gaps = 20/263 (7%) Query: 18 EALTGVCSRTIQHSDSQVNRLEITNDK-KLLATAGHQNVRLYDIRTTNPNPVASF--EGH 74 + T + + + ++ + LL T +V D R H Sbjct: 96 DVSTANKALDLSLKEFGPYHIKYAKNGTHLLITGRKGHVASMDWRKGQLRAELFLNETCH 155 Query: 75 RGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISC 134 S ++ Q+ ++ + + T ++D + R +H + P L++ Sbjct: 156 -----SATYLQNEQYFAVAQKKYT-FIYDHEGTELHRLKQHIEA-RHLDFLPYHYLLVTA 208 Query: 135 DRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDA 194 G ++ D+ Q +L + + +++ +++ ++ G +W Sbjct: 209 GETGWLKYHDVSTGQLVSELRTKAGPT-MAMAQNPWNAVMHLGHSNGTVSLWSPSMP--- 264 Query: 195 SHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVW 254 +P+ K + + I + ++AT AD + ++W I + FK +++ Sbjct: 265 ---EPLVKLLSARGPVNSIAIDRSGYYMATTGADRSMKIWDIRN-FKQLHSVESLPTPGT 320 Query: 255 DCAFSADSAYLVTASSDHYVRLW 277 + + S L+ S +V LW Sbjct: 321 NVSISDTG--LLALSRGPHVTLW 341 Score = 63.6 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 32/222 (14%), Positives = 72/222 (32%), Gaps = 11/222 (4%) Query: 81 VSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNI 140 + + ++ ++ + G + D R + N + N+ + Sbjct: 116 IKYAKNGTHLLITGRKGHVASMDWRKGQLRAELFLNETCHSATYLQNEQYFAVA-QKKYT 174 Query: 141 RIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPV 200 I+D E H+L + + L +L A G + D S + V Sbjct: 175 FIYD-HEGTELHRLKQHIEA--RHLDFLPYHYLLVTAGETG------WLKYHDVSTGQLV 225 Query: 201 TKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSA 260 ++ R + + + + ++ T +WS L L + V A Sbjct: 226 SELRTKAGPTMAMAQNPWNAVMHLGHSNGTVSLWSPSMPEPLVKLLSA-RGPVNSIAIDR 284 Query: 261 DSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 Y+ T +D +++WD+ + + V+++D Sbjct: 285 SGYYMATTGADRSMKIWDIRNFKQLHSVESLPTPGTNVSISD 326 >3EI3-B nrPDB Length = 383 Score = 67.8 bits (164), Expect = 6e-12, Method: Composition-based stats. Identities = 32/294 (10%), Positives = 81/294 (27%), Gaps = 19/294 (6%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQH--SDSQVNRLEIT--NDKKLLATAGHQNVRLY 58 + I W+ + IQ + ++ N +L ++ L Sbjct: 87 TTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDAITGMKFNQFNTNQLFVSSIRGATTLR 146 Query: 59 DIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAP 118 D + A + V + + T G + + + I + H A Sbjct: 147 DFSGSVIQVFAKTDSWDYWYCCVDVSVSRQMLATGDSTGRLLLLGLDGHEIFKEKLHKAK 206 Query: 119 VNEVVIHPNQGELISCDR-DGNIRIWDLGENQCTHQLT---PEDDTSLQSLSMASDGSML 174 V +P L++ D +++WDL + + P + + +D + L Sbjct: 207 VTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNAAYFNPTDSTKL 266 Query: 175 AAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSA------- 227 + + V+ + + + + + + Sbjct: 267 LTTDQRNEIRVYSSYDWSKPDQIIIHPHRQFQHLTPIKATWHPMYDLIVAGRYPDDQLLL 326 Query: 228 --DHTARVWSIDDDFKLETTLDGHQRWVWDC-AFSADSAYLVTASSDHYVRLWD 278 T ++ + + D + + FS L + + + +W+ Sbjct: 327 NDKRTIDIYDANSGGLVHQLRDPNAAGIISLNKFSPTGDVLASGMGFN-ILIWN 379 Score = 45.4 bits (106), Expect = 3e-05, Method: Composition-based stats. Identities = 34/191 (17%), Positives = 65/191 (34%), Gaps = 13/191 (6%) Query: 119 VNEVVIHPNQGE-LISCDRDGNIRIWDLGENQCTHQLTP-EDDTSLQSLSMA-SDGSMLA 175 V + HP + + G+I +WD T + ++ + + + L Sbjct: 76 VTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDAITGMKFNQFNTNQLF 135 Query: 176 AANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWS 235 ++ +G + + ++ K + + + +S + LAT D T R+ Sbjct: 136 VSSIRGATTLRDFSGSV----IQVFAKTDSWDYWYCCVDVSVSRQMLATG--DSTGRLLL 189 Query: 236 IDDDFKLETTLDGHQRWVWDCAFSADSAYL-VTASSDHYVRLWDLST---REIVRQYGGH 291 + D H+ V F+ +L T+S D V+LWDL + H Sbjct: 190 LGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMPH 249 Query: 292 HKGAVCVALND 302 K N Sbjct: 250 EKPVNAAYFNP 260 >5WLC-LS nrPDB Length = 594 Score = 66.2 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 58/336 (17%), Positives = 107/336 (31%), Gaps = 60/336 (17%) Query: 3 VILVSAGYDHTIRFW--EALTGVCSRTIQHSDSQVNRLEIT------NDKKLLATAGHQN 54 +L++ GYD T+R + + T ++ S + N + + + Sbjct: 261 PLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFYTSLSNQNQQNIFTAGRRRY 320 Query: 55 VRLYDI--------RTTNPNPVASFEGHRG--------NVTSVSFQQDNR---WMVTSSE 95 + +D+ +T + GH V + Q N ++ Sbjct: 321 MHSWDLSLENLTHSQTAKIEKFSRLYGHESTQRSFENFKVAHLQNSQTNSVHGIVLLQGN 380 Query: 96 DGTIKVWDVRSPSIPRNYKHNAPVN--EVVIHP-----NQGELISCDRDGNIRIWDLGEN 148 +G I + S K + + P + LI+ + G + +DL +N Sbjct: 381 NGWINILHSTSGLWLMGCKIEGVITDFCIDYQPISRGKFRTILIAVNAYGEVWEFDLNKN 440 Query: 149 Q--------------CTHQLTPEDDTSLQSLSMAS--DGSMLAAANTKGNCYVWEMPNHT 192 Q+ T+ +L ++ LA + G +++ N Sbjct: 441 GHVIRRWKDQGGVGITKIQVGGGTTTTCPALQISKIKQNRWLAVGSESGFVNLYDRNNAM 500 Query: 193 DASHLKPVTKFRAHSTYITRILLSSDVKHLATCS---ADHTARVW----SIDDDFKLETT 245 +S PV +T I+ + S D + L S D V S+ ++ T Sbjct: 501 TSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRAVKDALRLVHLPSCSVFSNWPTSGT 560 Query: 246 LDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLST 281 G V AFS L + VRLW L+ Sbjct: 561 PLG---KVTSVAFSPSGGLLAVGNEQGKVRLWKLNH 593 Score = 46.6 bits (109), Expect = 1e-05, Method: Composition-based stats. Identities = 41/238 (17%), Positives = 84/238 (35%), Gaps = 30/238 (12%) Query: 42 NDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKV 101 ++ KLL VRL D ++P+ H + S+SF ++T D T+++ Sbjct: 223 SNSKLLPPKKLDIVRLKDANASHPS-------HSA-IQSLSFHPSKPLLLTGGYDKTLRI 274 Query: 102 WDVRSPS---IPRNYKHNAPVNEVVI-----HPNQGELISCDRDGNIRIWDLGENQCTHQ 153 + + + + + +P+ + NQ + + R + WDL TH Sbjct: 275 YHIDGKTNHLVTSLHLVGSPIQTCTFYTSLSNQNQQNIFTAGRRRYMHSWDLSLENLTHS 334 Query: 154 LTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRI 213 T + + + G + + + T++ H + + ++ +I I Sbjct: 335 QTAKIEKFSRLY-----GHESTQRSFENFKVAHLQNSQTNSVHG--IVLLQGNNGWIN-I 386 Query: 214 LLSSDVKHLATCSADHTARVWSID----DDFKLETTLDGHQ--RWVWDCAFSADSAYL 265 L S+ L C + + ID K T L VW+ + + + Sbjct: 387 LHSTSGLWLMGCKIEGVITDFCIDYQPISRGKFRTILIAVNAYGEVWEFDLNKNGHVI 444 Score = 32.0 bits (71), Expect = 0.37, Method: Composition-based stats. Identities = 10/60 (16%), Positives = 19/60 (31%), Gaps = 3/60 (5%) Query: 232 RVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW--DLSTREIVRQYG 289 + I + H + +F L+T D +R++ D T +V Sbjct: 231 KKLDIVRLKDANASHPSHS-AIQSLSFHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLH 289 >5TF2-A nrPDB Length = 407 Score = 65.5 bits (158), Expect = 3e-11, Method: Composition-based stats. Identities = 35/240 (14%), Positives = 72/240 (30%), Gaps = 46/240 (19%) Query: 81 VSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGELISCDRDGN 139 V F DN + T DG ++VW V S +K H + ++ + P+ +L++ RD Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDG-KLVTVGRDLK 236 Query: 140 IRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVW------------- 186 +W D + L +G ++ + + Sbjct: 237 ASVWQ-------------KDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLF 283 Query: 187 --------------EMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTAR 232 D S+ P+ ++ + +S L + + Sbjct: 284 TVQIPHKRLRQPPPCYLTAWDGSNFLPLRTKSCGHEVVSCLDVSESGTFLGLGTVTGSVA 343 Query: 233 VWSIDDDFKLETTLDGHQRWVWDCAFSAD---SAYLVTASSDHYVRLWDLSTREIVRQYG 289 ++ L + H V D AF + L+ S + + + +R + Sbjct: 344 IYIAFSLQCLYYVREAHGIVVTDVAFLPEKGRGPELL-GSHETALFSVAVDSRCQLHLLP 402 Score = 59.3 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 31/255 (12%), Positives = 79/255 (30%), Gaps = 34/255 (13%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIR 61 + +L + G D +R W+ + + + ++ L + D KL+ ++ Sbjct: 184 NTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGKLVTVGRDLKASVWQKD 243 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNE 121 VT + +Q++ ++ + + Sbjct: 244 --------------QLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLFTVQIPH 289 Query: 122 VVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKG 181 + ++ DG+ L C H++ + L ++ G+ L G Sbjct: 290 KRLRQPPPCYLTA-WDGS-NFLPLRTKSCGHEV-------VSCLDVSESGTFLGLGTVTG 340 Query: 182 NCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSD---VKHLATCSADHTARVWSIDD 238 + ++ + +++ AH +T + + L H ++S+ Sbjct: 341 SVAIYIAFSLQCLYYVRE-----AHGIVVTDVAFLPEKGRGPELLGS---HETALFSVAV 392 Query: 239 DFKLETTLDGHQRWV 253 D + + L +R V Sbjct: 393 DSRCQLHLLPSRRSV 407 Score = 45.8 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 14/47 (29%), Positives = 23/47 (48%) Query: 256 CAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 F+ D+ L T +D YVR+W + + E V ++ H +AL Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGP 224 >3DW8-B nrPDB Length = 447 Score = 63.9 bits (154), Expect = 7e-11, Method: Composition-based stats. Identities = 43/347 (12%), Positives = 109/347 (31%), Gaps = 100/347 (28%) Query: 35 VNRLEITNDKKLLATAGHQNV----------RLYDIRTTNPNPVASFEGHR--------- 75 ++ +E + +LLAT ++ N ++F+ H Sbjct: 31 ISTVEFNHSGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSL 90 Query: 76 ---GNVTSVSFQQ--DNRWMVTSSEDGTIKVWDV-------------------RSPSIPR 111 + + + + + S+ D TIK+W + R P+ Sbjct: 91 EIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVT 150 Query: 112 NYK----------------------HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQ 149 + H +N + I+ + +S D D I +W L Sbjct: 151 TLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSAD-DLRINLWHLEITD 209 Query: 150 CTHQLT-------PEDDTSLQSLSMASDG-SMLAAANTKGNCYVWEMPNHTDASHLKPVT 201 + + E + + + + +++KG + +M + Sbjct: 210 RSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLF 269 Query: 202 KFRAHST----------YITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQ- 250 + + I+ + S +++ T + +VW ++ + + T H+ Sbjct: 270 EEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDY-LSVKVWDLNMENRPVETYQVHEY 328 Query: 251 -----------RWVWD---CAFSADSAYLVTASSDHYVRLWDLSTRE 283 ++D C ++ + ++T S +++ R++D +T+ Sbjct: 329 LRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKR 375 Score = 45.1 bits (105), Expect = 4e-05, Method: Composition-based stats. Identities = 30/206 (14%), Positives = 73/206 (35%), Gaps = 46/206 (22%) Query: 6 VSAGYDHTIRFWEALTGVCSRTI-QHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTN 64 SA D + +E +R+ S ++ ++ ++ + + T + +V+++D+ N Sbjct: 258 ASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKVWDLNMEN 317 Query: 65 PNPVASFEGH---RGNVTSV------------SFQQDNRWMVTSSEDGTIKVWDVRSPSI 109 PV +++ H R + S+ + + ++T S + +++D + Sbjct: 318 -RPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTK-- 374 Query: 110 PRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSL---- 165 L + + R C +D+ S+ SL Sbjct: 375 -----------------RDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNK 417 Query: 166 -----SMASDGSMLAAANTKGNCYVW 186 + +++A A T N Y++ Sbjct: 418 KILHTAWHPKENIIAVATT-NNLYIF 442 Score = 35.0 bits (79), Expect = 0.035, Method: Composition-based stats. Identities = 20/132 (15%), Positives = 45/132 (34%), Gaps = 29/132 (21%) Query: 176 AANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWS 235 A GN W A V A + I+ + + + LAT ++ Sbjct: 2 AGAGGGNDIQWCFSQVKGA-----VDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQ 56 Query: 236 IDDDFKLET----------TLDGHQRW------------VWDCAFSA--DSAYLVTASSD 271 + + K+++ T H+ + + ++A + +++D Sbjct: 57 QEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTND 116 Query: 272 HYVRLWDLSTRE 283 ++LW +S R+ Sbjct: 117 KTIKLWKISERD 128 >6N8P-A nrPDB Length = 979 Score = 61.6 bits (148), Expect = 4e-10, Method: Composition-based stats. Identities = 33/228 (14%), Positives = 77/228 (33%), Gaps = 27/228 (11%) Query: 79 TSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDG 138 +++ + R + + G IK++ ++ N V ++ + P Q +L++ D Sbjct: 25 SALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQENNAVTQIHLLPGQCQLVTLLDDN 84 Query: 139 NIRIWDLGENQCTHQLTPEDDTS-------------LQSLSMASDGSMLAAANTKGNCYV 185 ++ +W L +L ++ + + + S +L GN +V Sbjct: 85 SLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGTESGNVFV 144 Query: 186 WEMPNH--------TDASHLKPVTKFRAHSTYITRIL----LSSDVKHLATCSADHTARV 233 ++P + + L+ + + H + D + + + Sbjct: 145 VQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVI 204 Query: 234 WSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLST 281 W + L L Q + + D LV+ SD W +S+ Sbjct: 205 WDLQGSRVLYHFLSSQQLE--NIWWQRDGRLLVSCHSDGSYCQWPVSS 250 Score = 50.1 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 41/263 (15%), Positives = 84/263 (31%), Gaps = 50/263 (19%) Query: 22 GVCSRTIQHS-DSQVNRLEITNDKKLLATAG-HQNVRLYDIRTTNPNPVASFEG-HRGN- 77 ++T++H Q + L + ++LA ++LY P F G H+ N Sbjct: 10 FQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLY------GAPGVEFMGLHQENN 63 Query: 78 -VTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHN---------------APVNE 121 VT + +VT +D ++ +W ++ + + + Sbjct: 64 AVTQIHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITV 123 Query: 122 VVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQ----------------SL 165 V+ H + L GN+ + L + T D LQ +L Sbjct: 124 VLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEMVEAL 183 Query: 166 SMAS-DGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLAT 224 D + + ++G +W++ H + I D + L + Sbjct: 184 QEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLEN-------IWWQRDGRLLVS 236 Query: 225 CSADHTARVWSIDDDFKLETTLD 247 C +D + W + + + L Sbjct: 237 CHSDGSYCQWPVSSEAQQPEPLR 259 Score = 46.2 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 40/249 (16%), Positives = 85/249 (34%), Gaps = 41/249 (16%) Query: 3 VILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITN-DKKLLATAGHQNVRLYDIR 61 IL I+ + GV + ++ V ++ + +L+ ++ L+ ++ Sbjct: 34 RILAIGTRSGAIKLY-GAPGVEFMGLHQENNAVTQIHLLPGQCQLVTLLDDNSLHLWSLK 92 Query: 62 TT------NPNPVASFEGHRGN------VTSVSFQQDNRWMVTSSEDGTIKVW------- 102 + + G G +T V + +E G + V Sbjct: 93 VKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGTESGNVFVVQLPAFRA 152 Query: 103 --------DVRSPSIPRNYKHNAP---VNEVVIHPNQ-GELISCDRDGNIRIWDLGENQC 150 D +P +H V + HP +++ G + IWDL ++ Sbjct: 153 LEDRTISSDAVLQRLPEEARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRV 212 Query: 151 THQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTY- 209 + L+++ DG +L + ++ G+ W P ++A +P+ + + Sbjct: 213 LYHFLSSQQ--LENIWWQRDGRLLVSCHSDGSYCQW--PVSSEAQQPEPLRSLVPYGPFP 268 Query: 210 ---ITRILL 215 ITRIL Sbjct: 269 CKAITRILW 277 Score = 43.1 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 43/282 (15%), Positives = 75/282 (26%), Gaps = 60/282 (21%) Query: 44 KKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWD 103 ++L V ++D++ + N+ +Q+D R +V+ DG+ W Sbjct: 191 NQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIW---WQRDGRLLVSCHSDGSYCQWP 247 Query: 104 VRSP--------SIPRNYKHN-APVNEVVI-------------------HPNQGELISCD 135 V S S+ + ++ IS Sbjct: 248 VSSEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRHCISVI 307 Query: 136 RDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDAS 195 DG +D + E D + D + V ++ Sbjct: 308 HDGQQTAFDFTSRVIGFTVLTEADP-----AATFDDPYALVVLAEEELVVIDLQTAGWPP 362 Query: 196 HLKPVTKFRAHSTYITRILLSSDV------KHLATCSADH---TARVWSIDDDFKLETTL 246 P H + IT S++ + +A S + + W ID L Sbjct: 363 VQLPYLA-SLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAP 421 Query: 247 DGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQY 288 L+T D VR WD S +R Sbjct: 422 -------------PQRDLLLTGHEDGTVRFWDAS-GVCLRLL 449 Score = 35.4 bits (80), Expect = 0.029, Method: Composition-based stats. Identities = 30/179 (16%), Positives = 55/179 (30%), Gaps = 29/179 (16%) Query: 32 DSQVNRLEITNDKKLLATAGHQNVRL----YDIRTTNPNPVASFEGHRGNVTSVSFQQDN 87 V+ + + ++++A QN + I A Sbjct: 379 SHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPA--------------PPQR 424 Query: 88 RWMVTSSEDGTIKVWDVRSPSIPRNYKHNA-PVNEVVIHPNQGELISCDRDGNIRIWDLG 146 ++T EDGT++ WD + YK + V PN+ + D + Sbjct: 425 DLLLTGHEDGTVRFWDASGVCLRLLYKLSTVRVFLTDTDPNEN-FSAQGEDEWPPL---- 479 Query: 147 ENQCTHQLTPEDDTS---LQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTK 202 + P D +Q + + LA A T G V E+ + ++ V Sbjct: 480 --RKVGSFDPYSDDPRLGIQKIFLCKYSGYLAVAGTAGQVLVLELNDEAAEQAVEQVEA 536 Score = 34.3 bits (77), Expect = 0.066, Method: Composition-based stats. Identities = 14/50 (28%), Positives = 25/50 (50%), Gaps = 2/50 (4%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQH-SDSQVNRLEITNDKKLLATAGH 52 +L++ D T+RFW+A +GVC R + S +V + ++ A Sbjct: 426 LLLTGHEDGTVRFWDA-SGVCLRLLYKLSTVRVFLTDTDPNENFSAQGED 474 >3WJ9-A nrPDB Length = 412 Score = 57.8 bits (138), Expect = 6e-09, Method: Composition-based stats. Identities = 40/299 (13%), Positives = 94/299 (31%), Gaps = 43/299 (14%) Query: 11 DHT----IRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPN 66 D T ++ W TG + + L+ T D+ L A V Y+ + Sbjct: 99 DGTPKQNMKVWNTETGQLVFSFVQRNQTGWNLQYTCDESLAARLVTNEVHFYETGNMSKG 158 Query: 67 PVASFEGHRGNVTSVSFQQDNRWMVT------SSEDGTIKVWDVRSPSIPRNYK--HNAP 118 P+A ++ + V +++ + + + + P + K A Sbjct: 159 PIAKLR--VEGISDFALSPGQNHAVAVFIPEKKGAPASVRTYSIPNFNSPLSQKTFFKAD 216 Query: 119 VNEVVIHPNQGELISCDR---DGNIRIWDLGENQCTHQLTPEDDT--------SLQSLSM 167 + + L+ + D + + + N +T + D + + Sbjct: 217 KVQFKWNALGTSLLVLTQTEVDKSNKNYYGETNLYLLGITGQFDCRVDLDREGPIHDVCW 276 Query: 168 ASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSA 227 +D N + + P ++ S + +++ Sbjct: 277 NADSKEFGIVYGYMPAKTAIFDNRANVVSIIP-------PAPRNTLIFSPNSRYILLAGF 329 Query: 228 D---HTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASS------DHYVRLW 277 + ++ ++ K TT++ C FS DS +L+TA + D+ +++W Sbjct: 330 GNLQGSIDIFDAANNMKKITTVEAAN--CTYCEFSPDSQFLLTAVTSPRLRVDNSIKIW 386 >2VDU-B nrPDB Length = 450 Score = 57.4 bits (137), Expect = 8e-09, Method: Composition-based stats. Identities = 32/179 (17%), Positives = 75/179 (41%), Gaps = 12/179 (6%) Query: 119 VNEVVIHPNQGELISC-DRDGNIRIWDL---GENQCTHQLTPEDDTSLQSLSMASDGSML 174 + + + ++ LI+C D D ++ ++D+ +N + ++S+A D + + Sbjct: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTV 164 Query: 175 AAANTKGNCYVWEMPNHTDAS-HLKPVTKFRAHSTYITRILLSSDV---KHLATCSADHT 230 A+ G+ Y ++ + + +P+ H + +T + L D + + T D Sbjct: 165 IIADKFGDVYSIDINSIPEEKFTQEPIL---GHVSMLTDVHLIKDSDGHQFIITSDRDEH 221 Query: 231 ARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYG 289 ++ F ++ L GH+ +V D L++A D + WD T + + + Sbjct: 222 IKISHYPQCFIVDKWLFGHKHFVSSICCGKD-YLLLSAGGDDKIFAWDWKTGKNLSTFD 279 Score = 42.0 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 26/172 (15%), Positives = 55/172 (31%), Gaps = 17/172 (9%) Query: 84 QQDNRWMVTSSEDGTIKVWDVRSPS-----IPRNYKHNAPVNEVVIHPNQGELISCDRDG 138 ++R + + D ++ V+DV S + + + + N + I + +I D+ G Sbjct: 112 SDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVIIADKFG 171 Query: 139 NIRIWDLG----ENQCTHQLTPE-DDTSLQSLSMASDGS-MLAAANTKGNCYVWEMPNHT 192 ++ D+ E + + L SDG + ++ + + P Sbjct: 172 DVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKISHYPQC- 230 Query: 193 DASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLET 244 H +++ I D L + D W L T Sbjct: 231 ----FIVDKWLFGHKHFVSSICCGKD-YLLLSAGGDDKIFAWDWKTGKNLST 277 Score = 41.2 bits (95), Expect = 5e-04, Method: Composition-based stats. Identities = 14/100 (14%), Positives = 40/100 (40%), Gaps = 12/100 (12%) Query: 28 IQHSDSQVNRLEITNDKK----LLATAGHQNVRLYDIRTTNPNPVAS---FEGHRGNVTS 80 I S + + + D ++ + +++++ + P GH+ V+S Sbjct: 191 ILGHVSMLTDVHLIKDSDGHQFIITSDRDEHIKI----SHYPQCFIVDKWLFGHKHFVSS 246 Query: 81 VSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVN 120 + +D ++++ D I WD ++ + +N+ + Sbjct: 247 ICCGKD-YLLLSAGGDDKIFAWDWKTGKNLSTFDYNSLIK 285 Score = 38.1 bits (87), Expect = 0.005, Method: Composition-based stats. Identities = 10/64 (15%), Positives = 24/64 (37%), Gaps = 5/64 (7%) Query: 4 ILVSAGYDHTIRFWEALTGVC---SRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDI 60 ++++ D I+ + C + + V+ + D LL+ G + +D Sbjct: 212 FIITSDRDEHIKI--SHYPQCFIVDKWLFGHKHFVSSICCGKDYLLLSAGGDDKIFAWDW 269 Query: 61 RTTN 64 +T Sbjct: 270 KTGK 273 >5WLC-LV nrPDB Length = 707 Score = 56.2 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 34/280 (12%), Positives = 91/280 (32%), Gaps = 31/280 (11%) Query: 36 NRLEITNDKKL-LATAGHQ-NVRLYDIRTTNPNPVASFEGHRG------NVTSVSFQQDN 87 N+++++ D + +AT ++ + +YD N F+ H + S + + Sbjct: 60 NKIKVSRDGQYCMATGTYKPQIHVYDFA----NLSLKFDRHTDAENVDFTILSDDWTKSV 115 Query: 88 RWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGE 147 D +I+ + + + +V + +L + +L + Sbjct: 116 HL----QNDRSIQFQN--KGGLHYTTRIPKFGRSLVYNKVNCDLYVGASGNELYRLNLEK 169 Query: 148 NQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHS 207 + + + + + +S+ +LAA W+ + + S L Sbjct: 170 GRFLNPFKLDTE-GVNHVSINEVNGLLAAGTETNVVEFWDPRSRSRVSKLYLENNIDNRP 228 Query: 208 TYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSAD---SAY 264 +T +D A +++ + ++ + G+ + + + Sbjct: 229 FQVTTTSFRNDGLTFACGTSNGYSYIYDLRTSEPSIIKDQGYGFDIKKIIWLDNVGTENK 288 Query: 265 LVTASSDHYV-RLWDLSTREIVRQYGGHHKGAVCVALNDV 303 +VT D + ++WD + V +ND+ Sbjct: 289 IVTC--DKRIAKIWDRLDGKAYASME------PSVDINDI 320 >4AV8-A nrPDB Length = 339 Score = 53.9 bits (128), Expect = 8e-08, Method: Composition-based stats. Identities = 36/199 (18%), Positives = 72/199 (36%), Gaps = 11/199 (5%) Query: 84 QQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIW 143 + N S++ + +WD K +A V ++ + E I + I I+ Sbjct: 63 HRTNYIAFVSTKKELLHIWDDVKKQDITRVKLDAAVKDLFLS---REFIVVSQGDVISIF 119 Query: 144 DLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKF 203 +++T + +L +N + TDA + Sbjct: 120 KF--GNPWNKITEDIKFGGVCEFANG---LLVYSNEFNLGQIHVTRLQTDAEQVVGKGVL 174 Query: 204 -RAHSTYITRILLSSDVKHLATCSADHT-ARVWSIDDDFKLETTLDGHQRW-VWDCAFSA 260 +AH+ + + L+ +ATCS D T RV+ D+ + G R + D +S Sbjct: 175 VKAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWSP 234 Query: 261 DSAYLVTASSDHYVRLWDL 279 D + L S + ++++ Sbjct: 235 DGSKLAVVSDKWTLHVFEV 253 Score = 47.0 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 42/238 (17%), Positives = 88/238 (36%), Gaps = 21/238 (8%) Query: 16 FWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHR 75 W+ + ++ D+ V L ++ ++ + + + ++ NP + + Sbjct: 80 IWDDVKKQDITRVK-LDAAVKDLFLS--REFIVVSQGDVISIFKF--GNPWNKITEDIKF 134 Query: 76 GNVTSVSFQQDNRWMVTSSED-GTIKVWDVRS------PSIPRNYKHNAPVNEVVIHPNQ 128 G V + + + ++ + G I V +++ H PV V ++ Sbjct: 135 GGVCEFA---NGLLVYSNEFNLGQIHVTRLQTDAEQVVGKGVLVKAHANPVKMVRLNRKG 191 Query: 129 GELISCDRDGN-IRIWDLGENQCTHQLTPEDD-TSLQSLSMASDGSMLAAANTKGNCYVW 186 + +C +DG IR++ + D TS+ + + DGS LA + K +V+ Sbjct: 192 DMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWSPDGSKLAVVSDKWTLHVF 251 Query: 187 EMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLAT-CSADHTARVWSIDDDFKLE 243 E+ N DA + + V K + Y + K + S D W D + Sbjct: 252 EVFN--DAENKRHVLKDWINIKYFQSEWSICNFKLKVSKGSNDCKIA-WISDTGLVIV 306 >5WLC-LH nrPDB Length = 896 Score = 51.2 bits (121), Expect = 5e-07, Method: Composition-based stats. Identities = 43/307 (14%), Positives = 108/307 (35%), Gaps = 55/307 (17%) Query: 10 YDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVA 69 +++ I+ + T C +T++ +++ + +++ N + V Sbjct: 48 FNNQIKVYSVETRQCVKTLKFANNSLLSGIFLQEEE-----------------NNESIVK 90 Query: 70 SFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSI--PRNYKHNAPVNEVV--IH 125 G +V Q+D + + +G + V + + + P+++K + ++ H Sbjct: 91 ILLGD----ITVPQQEDAHLITVFTNNGHVIVLNYKGKLVESPKHFKISLADEKLANVFH 146 Query: 126 PNQGE-LISCDRD---------GNIRIWDLGENQCTHQLTPEDDTSLQSL---SMASDGS 172 +++ +D + R++ L + Q ++ +++S+G Sbjct: 147 SEGNYRILTTFKDPSQKAHNSLQSYRLYALTFDDAKKQFEVAHQAEWHNVILSNISSNGK 206 Query: 173 MLAAANTKGNCYVWEMPNHTDASHLKPVTKFRA---------------HSTYITRILLSS 217 +LA + E + + S ++ Y++ + + + Sbjct: 207 LLAHMCKDVSTKDHEHKSISVVSLFDDSVNLSFPLGSILSSQTQSLSYNTRYVSSMAIDN 266 Query: 218 DVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLW 277 + LA A + S+ D L H V +FS D +YL++ + + LW Sbjct: 267 MGQQLAVGFASGVISIVSLADL--QIRLLKWHIDSVLSLSFSHDGSYLLSGGWEKVMSLW 324 Query: 278 DLSTREI 284 L T Sbjct: 325 QLETNSQ 331 Score = 39.7 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 31/181 (17%), Positives = 70/181 (38%), Gaps = 36/181 (19%) Query: 78 VTSVSFQQDNRWMVT-----------SSEDGTIKV-----------WDVRSPSIPRNYKH 115 +T + F +D +WM+T SS+D T + W++++ + + Sbjct: 495 ITDLKFTKDGQWMITYEIEYPPNDLLSSKDLTHILKFWTKNDNETNWNLKT-KVINPHGI 553 Query: 116 NAPVNEVVIHP----NQGELISCDRDGNIRIWDL---GENQCTHQL---TPEDDTSLQSL 165 + P+ +++ P N ++ D +G ++ W N C ++ ++ SL Sbjct: 554 SVPITKILPSPRSVNNSQGCLTADNNGGLKFWSFDSHESNWCLKKISLPNFNHFSNSVSL 613 Query: 166 SMASDGSMLAAANTKG-NCYVWEM-PNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLA 223 + + DGS++ ++ + K V++F S I + L +D + Sbjct: 614 AWSQDGSLIFHGFDDKLQILDFDTFKKFESLENTKTVSEFTLDS-EIQTVKLINDTNLIV 672 Query: 224 T 224 Sbjct: 673 A 673 Score = 35.0 bits (79), Expect = 0.037, Method: Composition-based stats. Identities = 21/115 (18%), Positives = 39/115 (33%), Gaps = 11/115 (9%) Query: 169 SDGSMLAAANTKGNCYVW-EMPNHTDASHLKPVTKFRAHSTYITRILLSS----DVKHLA 223 +L++ + W + N T+ + V S IT+IL S + + Sbjct: 515 PPNDLLSSKDLTHILKFWTKNDNETNWNLKTKVINPHGISVPITKILPSPRSVNNSQGCL 574 Query: 224 TCSADHTARVWSIDD---DFKLETTL---DGHQRWVWDCAFSADSAYLVTASSDH 272 T + + WS D ++ L+ H A+S D + + D Sbjct: 575 TADNNGGLKFWSFDSHESNWCLKKISLPNFNHFSNSVSLAWSQDGSLIFHGFDDK 629 Score = 30.4 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 11/110 (10%), Positives = 37/110 (33%), Gaps = 15/110 (13%) Query: 39 EITNDKKLLATAGHQNVRLYDIRTTNPN-PVASFE----GHRGNVTSVSFQQDNRWMVTS 93 + N + L + ++ + + N + H N S+++ QD + Sbjct: 566 SVNNSQGCLTADNNGGLKFWSFDSHESNWCLKKISLPNFNHFSNSVSLAWSQDGSLIFHG 625 Query: 94 SEDGTIKVWD---------VRSPSIPRNYKHNAPVNEVVIHPNQGELISC 134 D +++ D + + + ++ + V + + +++ Sbjct: 626 -FDDKLQILDFDTFKKFESLENTKTVSEFTLDSEIQTVKLINDTNLIVAT 674 >2I3T-A nrPDB Length = 341 Score = 51.2 bits (121), Expect = 5e-07, Method: Composition-based stats. Identities = 55/300 (18%), Positives = 105/300 (35%), Gaps = 29/300 (9%) Query: 29 QHSDSQVNRLEITNDKKLL-ATAGHQNVRL--YDIRTTNPNPVASFEGHRGNVTSVSFQQ 85 Q ++ ++I K LL T+ ++ + +DI+ N + + S ++ + +F Sbjct: 8 QAPKDYISDIKIIPSKSLLLITSWDGSLTVYKFDIQAKNVDLLQSLR-YKHPLLCCNFID 66 Query: 86 DNR-WMVTSSEDGTIKVWDVR-SPSIPRNYKHNAPVNEVVIHPNQG-ELISCDRDGNIRI 142 + + + G I D+ SPS + A + I +LI+ DG I + Sbjct: 67 NTDLQIYVGTVQGEILKVDLIGSPSFQALTNNEANLGICRICKYGDDKLIAASWDGLIEV 126 Query: 143 WDLGENQ----CTHQLTPEDDTSLQSL-SMASDGSMLAAANTKGNCYVWEMPNHTDASHL 197 D L + + +M ++ S L + +P D + Sbjct: 127 IDPRNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVGMNNSQVQWFRLPLCEDDNGT 186 Query: 198 KPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDD-----DFKLETTLDGHQ-- 250 + + + LL + + A S D V DD + H+ Sbjct: 187 IEESGLKYQIRDV--ALLPKEQEGYACSSIDGRVAVEFFDDQGDDYNSSKRFAFRCHRLN 244 Query: 251 -------RWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGG-HHKGAVCVALND 302 V FS +L TA SD + W+L TR+ ++ + + V +A +D Sbjct: 245 LKDTNLAYPVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKNFAKFNEDSVVKIACSD 304 Score = 50.8 bits (120), Expect = 8e-07, Method: Composition-based stats. Identities = 42/293 (14%), Positives = 96/293 (32%), Gaps = 25/293 (8%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQHS---DSQVNRLEITNDKKLLATAGHQNVRLY 58 S++L++ +D ++ ++ + + S + ++ L G + Sbjct: 24 SLLLIT-SWDGSLTVYKFDIQAKNVDLLQSLRYKHPLLCCNFIDNTDLQIYVGTVQGEIL 82 Query: 59 DIRTTNPNPVASFEGHRGNVTSVSFQQDNR-WMVTSSEDGTIKVWDVRS-----PSIPRN 112 + + + N+ + ++ +S DG I+V D R+ ++ Sbjct: 83 KVDLIGSPSFQALTNNEANLGICRICKYGDDKLIAASWDGLIEVIDPRNYGDGVIAVKNL 142 Query: 113 YKHNAPVNEVVI--HPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDD--TSLQSLSMA 168 +N V + N LI + ++ + L + + E ++ +++ Sbjct: 143 NSNNTKVKNKIFTMDTNSSRLIVGMNNSQVQWFRLPLCEDDNGTIEESGLKYQIRDVALL 202 Query: 169 SDGSMLAAANT-KGNCYVWEMPNHTDASHLKPVTKFRAHS---------TYITRILLSSD 218 A ++ G V + D + FR H + I S Sbjct: 203 PKEQEGYACSSIDGRVAVEFFDDQGDDYNSSKRFAFRCHRLNLKDTNLAYPVNSIEFSPR 262 Query: 219 VKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSD 271 K L T +D W++ K++ ++ V A S D+ + S D Sbjct: 263 HKFLYTAGSDGIISCWNLQTRKKIKNFAKFNEDSVVKIACS-DNILCLATSDD 314 Score = 47.8 bits (112), Expect = 6e-06, Method: Composition-based stats. Identities = 13/66 (19%), Positives = 26/66 (39%) Query: 117 APVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAA 176 PVN + P L + DG I W+L + ++ S+ ++ + + LA Sbjct: 252 YPVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKNFAKFNEDSVVKIACSDNILCLAT 311 Query: 177 ANTKGN 182 ++ Sbjct: 312 SDDTFK 317 >6CVZ-A nrPDB Length = 351 Score = 51.2 bits (121), Expect = 6e-07, Method: Composition-based stats. Identities = 18/111 (16%), Positives = 44/111 (39%), Gaps = 2/111 (1%) Query: 60 IRTTNPNPVASFEGHRGNVTSVSFQQDNR-WMVTSSEDGTIKVWDVRSPSIPRNYKHNAP 118 + T N H + ++F R ++++S D TIK+ + + ++ + Y P Sbjct: 59 LSTANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNAGRP 118 Query: 119 VNEVVIHPNQ-GELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMA 168 V ++ + + +G+I ++D+ Q +S++ Sbjct: 119 VWSCCWCLDEANYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLS 169 Score = 51.2 bits (121), Expect = 6e-07, Method: Composition-based stats. Identities = 23/112 (20%), Positives = 50/112 (44%), Gaps = 5/112 (4%) Query: 193 DASHLKPVTKFRAHSTYITRILLSSDVK-HLATCSADHTARVWSIDDDFKLETTLDGHQR 251 +++K H I + SS ++ L + S D+T ++ S++ + ++T G R Sbjct: 60 STANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNAG--R 117 Query: 252 WVWDCAFSADS-AYLVTASSDHYVRLWDLS-TREIVRQYGGHHKGAVCVALN 301 VW C + D Y+ ++ + ++D+ T V++ V+L+ Sbjct: 118 PVWSCCWCLDEANYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLS 169 Score = 36.2 bits (82), Expect = 0.018, Method: Composition-based stats. Identities = 12/59 (20%), Positives = 26/59 (44%), Gaps = 1/59 (1%) Query: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLL-ATAGHQNVRLYDIR 61 +L+SA D+TI+ T +T + ++ + A + ++ +YD+R Sbjct: 89 LLLSASLDNTIKLTSLETNTVVQTYNAGRPVWSCCWCLDEANYIYAGLANGSILVYDVR 147 Score = 29.7 bits (65), Expect = 1.8, Method: Composition-based stats. Identities = 10/62 (16%), Positives = 29/62 (46%), Gaps = 3/62 (4%) Query: 86 DNRWMVTSSED--GTIKVWDVRSPSIPRNYKHNAPVNEVV-IHPNQGELISCDRDGNIRI 142 D +V + ++ + +WD S S+ ++ + + PV ++ N+ ++ + + I Sbjct: 288 DGNILVCTGDEAANSALLWDAASGSLLQDLQTDQPVLDICPFEVNRNSYLATLTEKMVHI 347 Query: 143 WD 144 + Sbjct: 348 YK 349 >5K1H-B nrPDB Length = 576 Score = 50.5 bits (119), Expect = 9e-07, Method: Composition-based stats. Identities = 30/214 (14%), Positives = 61/214 (28%), Gaps = 19/214 (8%) Query: 17 WEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRG 76 W+ + + + + E + ++ +G + ++ +PV+ E R Sbjct: 110 WDIPEKQPFKDLGNLRYWLEEAECRDQYSVIFESGDRTSIFWN---DVKDPVSIEERARW 166 Query: 77 NVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCD- 135 T V + ++ T + G I +W + + H V + P + L++ Sbjct: 167 TETYVRWSPKGTYLATFHQRG-IALWGGEKFKQIQRFSHQG-VQLIDFSPCERYLVTFSP 224 Query: 136 ------RDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMP 189 I IWD+ E + DG A ++E P Sbjct: 225 LMDTQDDPQAIIIWDILTGHKKRGFHCESSAHWPIFKWSHDGKFFARMTLD-TLSIYETP 283 Query: 190 NHTDASHLKPVTKFRAHSTYITRILLSSDVKHLA 223 + I S +A Sbjct: 284 SMGLLDKKSLKIS------GIKDFSWSPGGNIIA 311 Score = 43.1 bits (100), Expect = 1e-04, Method: Composition-based stats. Identities = 39/320 (12%), Positives = 90/320 (28%), Gaps = 52/320 (16%) Query: 2 SVILVSAGYDHTIRFWEALTGVCSRTIQ-HSDSQVNRLEITNDKKLLATAGHQNVRLYDI 60 S ++ + I W+ LTG R S + + ++D K A + +Y+ Sbjct: 223 SPLMDTQDDPQAIIIWDILTGHKKRGFHCESSAHWPIFKWSHDGKFFARMTLDTLSIYET 282 Query: 61 RTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVW-----DVRSPSIPRNYKH 115 + S + + S+ + W D+ + Sbjct: 283 PSMGLLDKKSLK--ISGIKDFSWSPGGNIIA---------FWVPEDKDIPARVTLMQLPS 331 Query: 116 NAPVN----------EVVIHPNQGELISCDRDGNIR----------IWDLGENQCTHQLT 155 + ++ N L D + I+ + E Q + Sbjct: 332 RQEIRVRNLFNVVDCKLHWQKNGDYLCVK-VDRTPKGTQGVVTNFEIFRMREKQVPVDVV 390 Query: 156 PEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILL 215 +T + + + +GS A + + + ++ F I Sbjct: 391 EMKET-IIAFAWEPNGSKFAVLHGEAPRISVSFYHVKSNGKIELSKMFD--KQQANTIFW 447 Query: 216 SSDVKHLATCS--ADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTA-SS-- 270 S + + + + A + D + + + D + Y+VT+ S Sbjct: 448 SPQGQFVVLAGLRSMNGALAFVDTSDCTVMNIAEHYMA--SDVEWDPTGRYVVTSVSWWS 505 Query: 271 ---DHYVRLWDLSTREIVRQ 287 D+ LW ++++ Sbjct: 506 HKVDNAYWLWTFQ-GRLLQK 524 Score = 32.7 bits (73), Expect = 0.19, Method: Composition-based stats. Identities = 21/86 (24%), Positives = 32/86 (37%), Gaps = 11/86 (12%) Query: 211 TRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTAS- 269 T + S +LAT +W + +++ HQ V FS YLVT S Sbjct: 169 TYVRWSPKGTYLATFHQ-RGIALWGGEKFKQIQR--FSHQG-VQLIDFSPCERYLVTFSP 224 Query: 270 -----SD-HYVRLWDLSTREIVRQYG 289 D + +WD+ T R + Sbjct: 225 LMDTQDDPQAIIIWDILTGHKKRGFH 250 >5BPW-A nrPDB Length = 843 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 38/196 (19%), Positives = 71/196 (36%), Gaps = 15/196 (7%) Query: 38 LEITNDKKLLATA-GHQNVRLYDIRTTNPNPVASF---EGHRGNVTSVSFQQDNRWMVTS 93 L + + L+A A V L+ + + + V SF E VT ++++ D + + + Sbjct: 26 LVWSPKRDLIALANTAGEVLLHRLASFHR--VWSFPPNENTGKEVTCLAWRPDGKLLAFA 83 Query: 94 SED-GTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTH 152 D I + DV P ++ APV+ + H + + S D Sbjct: 84 LADTKKIVLCDVEKPESLHSFSVEAPVSCM--HWMEVTVESSVLTSFYNAEDESNLLLPK 141 Query: 153 QLTPEDDTSLQSLSMA---SDGSMLAAANTKGNCYVWEMPNH---TDASHLKPVTKFRAH 206 T + S S + SD + + + N V + A + + + Sbjct: 142 LPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGGSSGFIELYAYGMFKIARVTGI 201 Query: 207 STYITRILLSSDVKHL 222 + + LSSD+K L Sbjct: 202 AGTCLALCLSSDLKSL 217 Score = 31.2 bits (69), Expect = 0.62, Method: Composition-based stats. Identities = 14/69 (20%), Positives = 24/69 (34%), Gaps = 7/69 (10%) Query: 15 RFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGH 74 R W +++ +V L D KLLA A ++ P + SF Sbjct: 54 RVWSFPPN------ENTGKEVTCLAWRPDGKLLAFALADTKKIVLCDVEKPESLHSFSV- 106 Query: 75 RGNVTSVSF 83 V+ + + Sbjct: 107 EAPVSCMHW 115 >4YHC-A nrPDB Length = 468 Score = 41.6 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 22/108 (20%), Positives = 44/108 (40%), Gaps = 4/108 (3%) Query: 187 EMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDD-FKLETT 245 + H + ++PV H I +I +S + K A+ D + VW + KL + Sbjct: 12 DTTLHEEKFRIEPVPVH--HQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLVLS 69 Query: 246 LDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHK 293 + R + A Y+ S D + + ++ + ++ Q+ H K Sbjct: 70 KEQMPRTLKAIALDPQGNYVSLFSKD-TLFILNVESPSLMLQHSYHSK 116 Score = 40.4 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 16/143 (11%), Positives = 50/143 (34%), Gaps = 13/143 (9%) Query: 74 HRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS---IPRNYKHNAPVNEVVIHPNQGE 130 H+ ++ ++ ++ + + D ++ VWD+R + + + + + P Sbjct: 29 HQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGNY 88 Query: 131 LISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQ-SLSMASDGSM--------LAAANTKG 181 + +D + I ++ Q + + + ++ L + G Sbjct: 89 VSLFSKD-TLFILNVESPSLMLQHSYHSKPNSKLNVFWMPGTHKDDEWKNFELVVVESSG 147 Query: 182 NCYVWEMPNHTDASHLKPVTKFR 204 V+ + + + + V KF+ Sbjct: 148 EIQVFSLTIEIEGADIALVEKFQ 170 Score = 34.7 bits (78), Expect = 0.052, Method: Composition-based stats. Identities = 18/91 (19%), Positives = 44/91 (48%), Gaps = 3/91 (3%) Query: 30 HSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNR 88 H + ++ ++ + K A+ G +++ ++D+R V S E + +++ Sbjct: 28 HHQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGN 87 Query: 89 WMVTSSEDGTIKVWDVRSPSIPRNYK-HNAP 118 ++ S+D T+ + +V SPS+ + H+ P Sbjct: 88 YVSLFSKD-TLFILNVESPSLMLQHSYHSKP 117 Score = 31.6 bits (70), Expect = 0.41, Method: Composition-based stats. Identities = 13/63 (20%), Positives = 22/63 (34%), Gaps = 4/63 (6%) Query: 226 SADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIV 285 S D T ++ F++E HQ + A S + + D + +WDL Sbjct: 10 STDTTL----HEEKFRIEPVPVHHQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTK 65 Query: 286 RQY 288 Sbjct: 66 LVL 68 Score = 31.6 bits (70), Expect = 0.42, Method: Composition-based stats. Identities = 7/76 (9%), Positives = 26/76 (34%), Gaps = 6/76 (7%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDS---QVNRLEITNDKKLLATAGHQNVRLYDIR 61 S G D ++ W+ C++ + + + + + ++ + + ++ Sbjct: 45 FASVGLDRSLVVWDLR-QWCTKLVLSKEQMPRTLKAIALDPQGNYVSLFSKDTLFILNVE 103 Query: 62 TTNPNPVASFEGHRGN 77 + + S+ H Sbjct: 104 SPSLMLQHSY--HSKP 117 Score = 28.9 bits (63), Expect = 3.1, Method: Composition-based stats. Identities = 10/83 (12%), Positives = 25/83 (30%), Gaps = 4/83 (4%) Query: 146 GENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRA 205 E + + ++++ + A+ + VW++ K V Sbjct: 17 EEKFRIEPVPVHHQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCT----KLVLSKEQ 72 Query: 206 HSTYITRILLSSDVKHLATCSAD 228 + I L +++ S D Sbjct: 73 MPRTLKAIALDPQGNYVSLFSKD 95 >5GRS-A nrPDB Length = 396 Score = 41.2 bits (95), Expect = 6e-04, Method: Composition-based stats. Identities = 21/106 (19%), Positives = 42/106 (39%), Gaps = 4/106 (3%) Query: 187 EMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDD-FKLETT 245 + H + ++PV H I +I +S + K A+ D VW + KL + Sbjct: 12 DTTLHEEKFRIEPVPVH--HQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLVLS 69 Query: 246 LDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGH 291 + R + A Y+ S D + + ++ + ++ Q+ H Sbjct: 70 KEQMPRTLKAIALDPQGNYVSLFSKD-TLFILNVESPSLMLQHSYH 114 Score = 40.4 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 17/143 (11%), Positives = 48/143 (33%), Gaps = 13/143 (9%) Query: 74 HRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS---IPRNYKHNAPVNEVVIHPNQGE 130 H+ ++ ++ ++ + + D + VWD+R + + + + + P Sbjct: 29 HQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGNY 88 Query: 131 LISCDRDGNIRIWDLGENQCTHQLTPE-DDTSLQSLSMASDGSM--------LAAANTKG 181 + +D + I ++ Q + S ++ L + G Sbjct: 89 VSLFSKD-TLFILNVESPSLMLQHSYHCKPNSKLNVFWMPGTHKDDEWKNFELVVVESSG 147 Query: 182 NCYVWEMPNHTDASHLKPVTKFR 204 V+ + + + + V KF+ Sbjct: 148 EIQVFSLTIEIEGADIALVEKFQ 170 Score = 32.3 bits (72), Expect = 0.29, Method: Composition-based stats. Identities = 18/91 (19%), Positives = 42/91 (46%), Gaps = 3/91 (3%) Query: 30 HSDSQVNRLEITNDKKLLATAG-HQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNR 88 H + ++ ++ + K A+ G + + ++D+R V S E + +++ Sbjct: 28 HHQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGN 87 Query: 89 WMVTSSEDGTIKVWDVRSPSIPRNYK-HNAP 118 ++ S+D T+ + +V SPS+ + H P Sbjct: 88 YVSLFSKD-TLFILNVESPSLMLQHSYHCKP 117 Score = 31.6 bits (70), Expect = 0.41, Method: Composition-based stats. Identities = 13/63 (20%), Positives = 22/63 (34%), Gaps = 4/63 (6%) Query: 226 SADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIV 285 S D T ++ F++E HQ + A S + + D + +WDL Sbjct: 10 STDTTL----HEEKFRIEPVPVHHQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTK 65 Query: 286 RQY 288 Sbjct: 66 LVL 68 Score = 30.0 bits (66), Expect = 1.2, Method: Composition-based stats. Identities = 7/88 (7%), Positives = 28/88 (31%), Gaps = 4/88 (4%) Query: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDS---QVNRLEITNDKKLLATAGHQNVRLYDIR 61 S G D + W+ C++ + + + + + ++ + + ++ Sbjct: 45 FASVGLDRCLVVWDLR-QWCTKLVLSKEQMPRTLKAIALDPQGNYVSLFSKDTLFILNVE 103 Query: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRW 89 + + S+ + +V + Sbjct: 104 SPSLMLQHSYHCKPNSKLNVFWMPGTHK 131 Score = 27.3 bits (59), Expect = 7.4, Method: Composition-based stats. Identities = 10/83 (12%), Positives = 24/83 (28%), Gaps = 4/83 (4%) Query: 146 GENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRA 205 E + + ++++ + A+ VW++ K V Sbjct: 17 EEKFRIEPVPVHHQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCT----KLVLSKEQ 72 Query: 206 HSTYITRILLSSDVKHLATCSAD 228 + I L +++ S D Sbjct: 73 MPRTLKAIALDPQGNYVSLFSKD 95 >5BPT-A nrPDB Length = 741 Score = 40.8 bits (94), Expect = 6e-04, Method: Composition-based stats. Identities = 34/201 (16%), Positives = 69/201 (34%), Gaps = 25/201 (12%) Query: 38 LEITNDKKLLA-TAGHQNVRLYDIRTTNPNPVASF---EGHRGNVTSVSFQQDNRWMVTS 93 L + + L+A V L+ R N V S E VT ++++ D + + Sbjct: 19 LAWSPKRDLIALVNKAGEVLLH--RLANIQRVWSLPPNENTGKEVTCLAWRPDGKILAFG 76 Query: 94 SED-GTIKVWDVRSPSIPRNYKHNAPVNEVVI--HPNQGELISC---DRDGN----IRIW 143 D + + DV P ++ P++ + + +++ D ++ Sbjct: 77 LADTKKVILCDVEKPESLHSFSLETPISCMQWMEVNVENSVLTSFYNAEDEANVLLPKLP 136 Query: 144 DLGENQCTHQLTPEDDTSLQSLSMASDGSM--LAAANTKGNCYVWEMPNHTDASHLKPVT 201 L +N ++ S + L + D + L G ++ A + + Sbjct: 137 ALPKNYTATAKIFSEEKSDEILKLLGDARLNALVLGGDSGQIEIY-------AYGMYKIA 189 Query: 202 KFRAHSTYITRILLSSDVKHL 222 R+ LSSD+K L Sbjct: 190 TISEVYGSCLRLCLSSDLKSL 210 Score = 31.6 bits (70), Expect = 0.47, Method: Composition-based stats. Identities = 11/69 (15%), Positives = 23/69 (33%), Gaps = 7/69 (10%) Query: 15 RFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGH 74 R W +++ +V L D K+LA ++ P + SF Sbjct: 47 RVWSLPPN------ENTGKEVTCLAWRPDGKILAFGLADTKKVILCDVEKPESLHSFSLE 100 Query: 75 RGNVTSVSF 83 ++ + + Sbjct: 101 T-PISCMQW 108 Score = 30.8 bits (68), Expect = 0.81, Method: Composition-based stats. Identities = 12/85 (14%), Positives = 27/85 (31%), Gaps = 3/85 (3%) Query: 207 STYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQ--RWVWDCAFSADSAY 264 I + S +A + + + + ++ + + V A+ D Sbjct: 13 PHEIIFLAWSPKRDLIALVNKAGEVLLHRLANIQRVWSLPPNENTGKEVTCLAWRPDGKI 72 Query: 265 LVTASSD-HYVRLWDLSTREIVRQY 288 L +D V L D+ E + + Sbjct: 73 LAFGLADTKKVILCDVEKPESLHSF 97 >4FHN-A nrPDB Length = 394 Score = 39.3 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 17/132 (12%), Positives = 40/132 (30%), Gaps = 11/132 (8%) Query: 158 DDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILL-- 215 D S LA + + + + H ++ I + Sbjct: 89 HDGDGNVNSSPVYSLFLACVCQDNTVRL-IITKNETIITQHVLGGKSGHHNFVNDIDIAD 147 Query: 216 --SSDVKH----LATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSA-YLVTA 268 S+D + +A+ D T +W + D+ + + F + L+ Sbjct: 148 VYSADNRLAEQVIASVGDDCTLIIWRLTDEGPILAGYPLSSPGI-SVQFRPSNPNQLIVG 206 Query: 269 SSDHYVRLWDLS 280 + +R++D + Sbjct: 207 ERNGNIRIFDWT 218 Score = 35.8 bits (81), Expect = 0.022, Method: Composition-based stats. Identities = 20/136 (14%), Positives = 45/136 (33%), Gaps = 21/136 (15%) Query: 75 RGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNY------KHNAPVNEVVIHP-- 126 V S+ ++ +D T+++ ++ +I + H+ VN++ I Sbjct: 97 SSPVYSL-------FLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIADVY 149 Query: 127 ------NQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 + + S D + IW L + P + S+ + L Sbjct: 150 SADNRLAEQVIASVGDDCTLIIWRLTDEGPILAGYPLSSPGISVQFRPSNPNQLIVGERN 209 Query: 181 GNCYVWEMPNHTDASH 196 GN +++ + A Sbjct: 210 GNIRIFDWTLNLSAEE 225 Score = 32.3 bits (72), Expect = 0.24, Method: Composition-based stats. Identities = 12/62 (19%), Positives = 25/62 (40%), Gaps = 2/62 (3%) Query: 4 ILVSAGYDHTIRFWEALT-GVCSRTIQHSDSQVN-RLEITNDKKLLATAGHQNVRLYDIR 61 ++ S G D T+ W G S ++ + +N +L+ + N+R++D Sbjct: 159 VIASVGDDCTLIIWRLTDEGPILAGYPLSSPGISVQFRPSNPNQLIVGERNGNIRIFDWT 218 Query: 62 TT 63 Sbjct: 219 LN 220 >6DAM-A nrPDB Length = 617 Score = 37.4 bits (85), Expect = 0.007, Method: Composition-based stats. Identities = 17/140 (12%), Positives = 42/140 (30%), Gaps = 10/140 (7%) Query: 38 LEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDG 97 + + +G+ Y+ + G ++S + ++T EDG Sbjct: 424 VSYSPQTGYFYISGNHVCMDYEPFEVEYTAGQPYVG-----ATLSMFPAGKDVITGKEDG 478 Query: 98 TIKV-----WDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTH 152 + + WD + I + K V + G + +G ++ D + + Sbjct: 479 SNNLGQFTAWDATTGKIIWSNKEQFSVWSGSLATAGGVVFYGTLEGYLKAVDAKTGKELY 538 Query: 153 QLTPEDDTSLQSLSMASDGS 172 + + +G Sbjct: 539 RFKTPSGIIGNVNTWEYEGK 558 >5OLJ-A nrPDB Length = 723 Score = 37.4 bits (85), Expect = 0.009, Method: Composition-based stats. Identities = 30/236 (12%), Positives = 73/236 (30%), Gaps = 26/236 (11%) Query: 24 CSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSV-- 81 + + +V + D +++A N+ + V + G + SV Sbjct: 131 LVKPLSEHVGKVMIPTFSPDGRMVAFVRDNNIFIKKFDFDTEVQVTT----DGQINSVLN 186 Query: 82 ---SFQQDNRWMVTS----SEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGEL--- 131 + + + VT+ S D + S Y P+ E ++P Sbjct: 187 GATDWVYEEEFGVTNLMSWSADNAFLAFVRSDESAVPEY--RMPMYEDKLYPEDYTYKYP 244 Query: 132 ISCDRDGNI--RIWDLGENQCTHQLTPED-DTSLQSLSMASDGSMLAAAN-----TKGNC 183 + +++ + ++++ + P D D + ++ + LA Sbjct: 245 KAGEKNSTVSLHLYNVADRNTKSVSLPIDADGYIPRIAFTDNADELAVMTLNRLQNDFKM 304 Query: 184 YVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDD 239 Y + L+ + K S +I + ++ D A ++ D+ Sbjct: 305 YYVHPKSLVPKLILQDMNKRYVDSDWIQALKFTAGGGFAYVSEKDGFAHIYLYDNK 360 Score = 32.3 bits (72), Expect = 0.27, Method: Composition-based stats. Identities = 21/123 (17%), Positives = 45/123 (36%), Gaps = 19/123 (15%) Query: 162 LQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLK--PVTKFRAHSTYITRILLSSDV 219 +Q+ ++S G + + Y ++ V H + S D Sbjct: 92 IQNYEVSSTGHHILLFTDMESIYRHSYRAAVYDYDVRRNLVKPLSEHVGKVMIPTFSPDG 151 Query: 220 KHLATCSADHT--ARVWSIDDDFKLET------TLDGHQRWVWD--------CAFSADSA 263 + +A D+ + + D + ++ T L+G WV++ ++SAD+A Sbjct: 152 RMVAFV-RDNNIFIKKFDFDTEVQVTTDGQINSVLNGATDWVYEEEFGVTNLMSWSADNA 210 Query: 264 YLV 266 +L Sbjct: 211 FLA 213 Score = 30.4 bits (67), Expect = 0.99, Method: Composition-based stats. Identities = 14/73 (19%), Positives = 21/73 (28%), Gaps = 10/73 (13%) Query: 233 VWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRL--WDLST-------RE 283 V+ D L L H V FS D + D+ + + +D T + Sbjct: 122 VYDYDVRRNLVKPLSEHVGKVMIPTFSPDGRMVAFV-RDNNIFIKKFDFDTEVQVTTDGQ 180 Query: 284 IVRQYGGHHKGAV 296 I G Sbjct: 181 INSVLNGATDWVY 193 >4NOX-A nrPDB Length = 746 Score = 37.4 bits (85), Expect = 0.009, Method: Composition-based stats. Identities = 39/309 (12%), Positives = 89/309 (28%), Gaps = 70/309 (22%) Query: 16 FWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHR 75 FW + ++ + L + Q V+L+ + + + F H Sbjct: 182 FWNNEKDQPENIVDRQHWTETFVQWSPLGTYLTSVHAQGVQLWGGASWSR--LRRFP-HP 238 Query: 76 GNVTSVSFQQDNRWMVTSS-----------------EDGT-IKVWDVRSPSIPRNY---- 113 V V+F +++VT S +DG +WD+ + R++ Sbjct: 239 -FVNLVAFSPGEKYLVTWSNRPIQIPDSGHPVLTLDDDGKNYIIWDIETARPLRSFAQQD 297 Query: 114 -------------KHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTH----QLTP 156 K PV + + ++ +I I++L + ++ Sbjct: 298 IHPEEHGPKKGPPKFPWPVF--KWSADDKYVARLNQGTSISIYELPKMNLLDKQAVKIEG 355 Query: 157 EDDTSLQSLSMASDG-----SMLA-----AANTKGNCYVWEMPNHTDASHLKPVTKFRAH 206 D ++ +G + N + +P+ + V Sbjct: 356 VMDFEWAPATVQREGVKTYEQLFCFWTPEIGNNPARVGLMSIPSK------QIVRTLNLF 409 Query: 207 STYITRILLSSDVKHLAT---------CSADHTARVWSIDDDFKLETTLDGHQRWVWDCA 257 S ++ S+ +L S T ++ + + +D + V + A Sbjct: 410 SVSDVKMHWQSEGTYLCVKVDRHSKSKKSQATTLEIFRVKEKGVPVEVVDTIKDTVINFA 469 Query: 258 FSADSAYLV 266 + V Sbjct: 470 WEPKGDRFV 478 Score = 35.0 bits (79), Expect = 0.043, Method: Composition-based stats. Identities = 20/97 (20%), Positives = 31/97 (31%), Gaps = 22/97 (22%) Query: 211 TRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVTAS- 269 T + S +L + A ++W +L +V AFS YLVT S Sbjct: 202 TFVQWSPLGTYLTSVHA-QGVQLWGGASWSRLRRFPHP---FVNLVAFSPGEKYLVTWSN 257 Query: 270 ----------------SDHYVR-LWDLSTREIVRQYG 289 D +WD+ T +R + Sbjct: 258 RPIQIPDSGHPVLTLDDDGKNYIIWDIETARPLRSFA 294 Score = 33.9 bits (76), Expect = 0.080, Method: Composition-based stats. Identities = 23/171 (13%), Positives = 58/171 (33%), Gaps = 26/171 (15%) Query: 18 EALTGVCSRTIQHSDSQVNRLEITNDKKLLATAG-----HQNVRLYDIRTTNPNPVASFE 72 + + RT++ + N + + + + A ++ +D+ P + Sbjct: 509 QVGSFKHLRTLEKKNH--NAIYWSPKGRFVVIATVHNTQSSDLEFWDLDFDGEKPENEKD 566 Query: 73 ----------GHRGNVTSVSFQQDNRWMVT--SSEDGTIK----VWDVRSPSIPRNYKHN 116 G +T V + R++ T S+ T++ ++D + R +H Sbjct: 567 LAACLQLMGTGDHYGITDVEWDPSGRYVATWASAWKHTMENGYHLYDF-KGELLRE-EHI 624 Query: 117 APVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSM 167 + P L++ + IR +L E + + S +++ Sbjct: 625 EKFKQWQWRPRPPTLLTKEEQKQIRK-NLREYSRIFEQEDAERISSADVAV 674 Score = 31.6 bits (70), Expect = 0.46, Method: Composition-based stats. Identities = 28/265 (10%), Positives = 71/265 (26%), Gaps = 54/265 (20%) Query: 18 EALTGVCSRTIQHSDSQVNRLEITNDKKLLAT----------AGHQNVRLYDIRTTNPNP 67 + RT+ ++ ++ L + + ++ ++ P Sbjct: 396 SIPSKQIVRTLNLFSVSDVKMHWQSEGTYLCVKVDRHSKSKKSQATTLEIFRVK-EKGVP 454 Query: 68 VASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPN 127 V + + V + +++ V PV + P Sbjct: 455 VEVVDTIKDTVINFAWEPKGDRFV--------------------IITTPEPVGATAVPPK 494 Query: 128 QGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGN----C 183 C +G + L ++ ++ + G + A Sbjct: 495 TSVSFFCPELKKGN--QVGSFKHLRTLEKKNHNAIY---WSPKGRFVVIATVHNTQSSDL 549 Query: 184 YVWEMP-------NHTDASHLKPVTKFRAHSTYITRILLSSDVKHLAT--CSADHTAR-- 232 W++ N D + + H IT + +++AT + HT Sbjct: 550 EFWDLDFDGEKPENEKDLAACLQLMGTGDHYG-ITDVEWDPSGRYVATWASAWKHTMENG 608 Query: 233 --VWSIDDDFKLETTLDGHQRWVWD 255 ++ + E ++ ++W W Sbjct: 609 YHLYDFKGELLREEHIEKFKQWQWR 633 >5WLC-LL nrPDB Length = 643 Score = 37.0 bits (84), Expect = 0.011, Method: Composition-based stats. Identities = 14/84 (16%), Positives = 32/84 (38%) Query: 60 IRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPV 119 I V +F GH V+++ + ++ + D + V+D+ S + + Sbjct: 173 IDIEEKKVVMTFPGHVSPVSTLQVITNEFFISGAEGDRFLNVYDIHSGMTKCVLVAESDI 232 Query: 120 NEVVIHPNQGELISCDRDGNIRIW 143 E+ + DG++ I+ Sbjct: 233 KELSHSGQADSIAVTTEDGSLEIF 256 Score = 36.2 bits (82), Expect = 0.019, Method: Composition-based stats. Identities = 30/196 (15%), Positives = 72/196 (36%), Gaps = 16/196 (8%) Query: 91 VTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVI----HPNQGELISCDRDGNIRIWDLG 146 TSS G VW+ + V + + +I +G I ++ + Sbjct: 37 ATSS--GVDTVWN---ENFLYLEDSKLKVTCLKWVNLASSDTVAIILGMNNGEIWLYSVL 91 Query: 147 ENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAH 206 N+ T++ T + ++ + + G+ L ++ Y +++ H + + + Sbjct: 92 ANEVTYKFTTGNSYEIKDIDLM--GNQLWCIDSSDAFYQFDLLQFKLLQHFRINNCVQLN 149 Query: 207 STYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLV 266 I S +A+ H+ + I++ K+ T GH V + ++ Sbjct: 150 KLTIVPAGDSVAQLLVAS----HSISLIDIEEK-KVVMTFPGHVSPVSTLQVITNEFFIS 204 Query: 267 TASSDHYVRLWDLSTR 282 A D ++ ++D+ + Sbjct: 205 GAEGDRFLNVYDIHSG 220 >2H47-A nrPDB Length = 390 Score = 36.6 bits (83), Expect = 0.015, Method: Composition-based stats. Identities = 16/73 (21%), Positives = 23/73 (31%) Query: 15 RFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGH 74 W T R + + I + L+ T NV +YDI P + + EG Sbjct: 316 EIWVMDTKTKQRVARIPGRDALSMTIDQQRNLMLTLDGGNVNVYDISQPEPKLLRTIEGA 375 Query: 75 RGNVTSVSFQQDN 87 V F Sbjct: 376 AEASLQVQFHPVG 388 >5CWW-B nrPDB Length = 595 Score = 36.2 bits (82), Expect = 0.016, Method: Composition-based stats. Identities = 21/101 (20%), Positives = 39/101 (38%), Gaps = 16/101 (15%) Query: 187 EMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTA---RVWSIDDDFKLE 243 ++ + + + +H+ +I + D HL D T + W++ Sbjct: 116 DIRQLVMSPNQDFLAVLTSHTVHICIL---PDSSHLHI--QDTTPFKPKFWTLGP----- 165 Query: 244 TTLDGHQRWVWDCAFSA---DSAYLVTASSDHYVRLWDLST 281 TT + V + + LVT + D VR+W+LST Sbjct: 166 TTHVTSRSAVVSAVWHPLGVNGHALVTVTEDAIVRVWELST 206 Score = 31.2 bits (69), Expect = 0.55, Method: Composition-based stats. Identities = 16/96 (16%), Positives = 35/96 (36%), Gaps = 10/96 (10%) Query: 32 DSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQ---DNR 88 S + I D L Q+ + + P V++V + + Sbjct: 133 TSHTVHICILPDSSHLHI---QDTTPFKPKFWTLGPTTHVTSRSAVVSAV-WHPLGVNGH 188 Query: 89 WMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVI 124 +VT +ED ++VW++ + + +AP + + Sbjct: 189 ALVTVTEDAIVRVWELST---ADRWTFDAPTLAIDL 221 >4GN8-A nrPDB Length = 299 Score = 36.2 bits (82), Expect = 0.016, Method: Composition-based stats. Identities = 32/230 (13%), Positives = 64/230 (27%), Gaps = 20/230 (8%) Query: 58 YDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRS---PSIPRNYK 114 +D + VA V+SV+ +Q ++ T W+ +S ++ K Sbjct: 42 WDTVSNQVQRVAV----DAPVSSVALRQLGGYVATIGTKFCALNWENQSVFVLAMVDEDK 97 Query: 115 HNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTS--------LQSLS 166 N N+ + P + + L P+ L Sbjct: 98 KNNRFNDGKVDPAGRYFAGTMAEETAPAVLERHQGSLYSLFPDHSVKKYFDQVDISNGLD 157 Query: 167 MASDGSML-AAANTKGNCYVWEMPNHT-DASHLKPVTKFRAHSTYITRILLSSDVKHLAT 224 + D + + ++ T S+ + V K + + ++ K Sbjct: 158 WSLDHKIFYYIDSLSYTVDAFDYDLQTGQISNRRIVYKMEKDEQIPDGMCIDAEGKLWVA 217 Query: 225 CSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSAD--SAYLVTASSDH 272 C + +L+T + C F S VT + D Sbjct: 218 CYNGGRVIRLDPETGKRLQTVKLPVDKT-TSCCFGGKDYSEMYVTCARDG 266 >4IMM-A nrPDB Length = 399 Score = 35.4 bits (80), Expect = 0.033, Method: Composition-based stats. Identities = 37/284 (13%), Positives = 86/284 (30%), Gaps = 30/284 (10%) Query: 8 AGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNP 67 + +A TG ++ + S + I+ DK ++ T + DI + Sbjct: 127 GTRSGKLIALDARTGAARWVVELASSSLAPALISGDKVIVITNS-GTIFGLDINSGATVW 185 Query: 68 VASFEGHRGNVTSVS--FQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHN--------A 117 + + +V ++ D R ++ DG I D + + + Sbjct: 186 QYATQVPNTSVRGMAKPLALDARTVLIGGADGRIHALDTMTGAPVWTRRVGLAMGSGEID 245 Query: 118 PVNEVVIHPN--QGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLA 175 + ++ P L + G + +D+ + L +L+ + Sbjct: 246 QLRDIDGTPTVVDHYLYAASYSGQLAGFDMTTGRTMFVSELSSTKKLTTLA-----DAVI 300 Query: 176 AANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWS 235 ++T G+ + + K+R + +T ++A AD + + Sbjct: 301 GSSTDGDVVAFNRMTGEKLWENHDL-KYRGLTNPVTI------GTYIAVGDADGVVHILN 353 Query: 236 IDDDFKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDL 279 G + + + L S+D V +W Sbjct: 354 HQGQIISRANTKG---ALTNLTVINNR--LYAQSADGVVTVWQF 392 >1Z68-A nrPDB Length = 719 Score = 34.7 bits (78), Expect = 0.049, Method: Composition-based stats. Identities = 34/259 (13%), Positives = 83/259 (32%), Gaps = 30/259 (11%) Query: 39 EITNDKKLLATAGHQNVRLYDIRTTNPNPV---ASFEGHRGNVTSVSFQQDNRWMVTSSE 95 + ++ L + N+ LY+I T + + + + + D +++ S+ Sbjct: 22 NWISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGL--SPDRQFVYLESD 79 Query: 96 DGTIK---------VWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLG 146 + ++D+ + R + P+ + P +L ++ G Sbjct: 80 YSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPG 139 Query: 147 ENQCTHQLTPEDDTSLQSL-SMASDGSMLAA-----ANTKGNCYVWEMPNHTDASHLKPV 200 + ++ + + MLA + G + N TD + Sbjct: 140 DPPFQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIA-- 197 Query: 201 TKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFSA 260 + Y I ++ + + + R++ ID + + + V S+ Sbjct: 198 YSYYGDEQYPRTI----NIPYPKAGAKNPVVRIFIIDTTYP--AYVGPQEVPVPAMIASS 251 Query: 261 DSAY-LVTASSDHYVRL-W 277 D + +T +D V L W Sbjct: 252 DYYFSWLTWVTDERVCLQW 270 >3FGB-A nrPDB Length = 361 Score = 34.7 bits (78), Expect = 0.053, Method: Composition-based stats. Identities = 46/276 (16%), Positives = 87/276 (31%), Gaps = 51/276 (18%) Query: 7 SAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPN 66 + G D G T +S ++ I D LL + + + + + Sbjct: 89 TGGEDPCYII---TNGSNVVTANYSGGSISVFPIDKDGSLLPAS-----EVVKFKGSGAD 140 Query: 67 PVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHP 126 + H + V D +++ D D+ + I H VN Sbjct: 141 KERQEKPH---LHCVRITPDGKYLF---AD------DLGTDQI-----HKFIVNPNAKAD 183 Query: 127 NQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVW 186 N+ + ++G+ + + LT + S L G+++A G Sbjct: 184 NEDVFL---KEGSPASYKVEAGSGPRHLTFAPNGSYAYLINELSGTVIAFEYNDGELK-- 238 Query: 187 EMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCS---ADHTARVWSIDDDFKLE 243 ++ + + I +S D K L + AD ++SI + + Sbjct: 239 ---------EIQTIAADTVGAKGSGDIHISPDGKFLYASNRLKADG-LAIFSIHPENGML 288 Query: 244 TT----LDG-HQRWVWDCAFSADSAYLVTASSDHYV 274 T L G H R + + + YL+ A D V Sbjct: 289 TKVGYQLTGIHPR---NFIITPNGKYLLVACRDSNV 321 Score = 32.3 bits (72), Expect = 0.28, Method: Composition-based stats. Identities = 21/132 (15%), Positives = 43/132 (32%), Gaps = 13/132 (9%) Query: 122 VVIHPNQGELISCDR-DGNIRIWDLGENQCTHQLTPEDDTSLQS----LSMASDGSMLAA 176 + PN + G + ++ + + T DT + ++ DG L A Sbjct: 208 LTFAPNGSYAYLINELSGTVIAFEYNDGELKEIQTIAADTVGAKGSGDIHISPDGKFLYA 267 Query: 177 AN---TKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSAD-HTAR 232 +N G ++ + H +++ + K+L D + + Sbjct: 268 SNRLKADG-LAIFSIHPENGMLTKVGYQLTGIHPR---NFIITPNGKYLLVACRDSNVIQ 323 Query: 233 VWSIDDDFKLET 244 V+ D D L T Sbjct: 324 VYERDTDTGLLT 335 >6IGB-A nrPDB Length = 364 Score = 34.3 bits (77), Expect = 0.064, Method: Composition-based stats. Identities = 24/152 (15%), Positives = 46/152 (30%), Gaps = 23/152 (15%) Query: 139 NIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLK 198 + +D + L ++ L+ A D L N G + + Sbjct: 20 QVYRFDGADGSVKGPLRVAHTSNPSYLTFAPDQRTLFVVNENGRGGKGDTVGRATSYRFD 79 Query: 199 PVT-------KFRAHSTYITRILLSSDVKHLATCSA----DHTARVWSIDDDFKL--ETT 245 P++ + + + + T LS D ++L + + + V + D L Sbjct: 80 PISGRLQQISQVQTLADHPTYSSLSHDGRYLFVANYSVQPEGSVAVLPVRADGSLAPVVQ 139 Query: 246 LDGHQ----------RWVWDCAFSADSAYLVT 267 ++ HQ V S D YL Sbjct: 140 VESHQASKVHPRQVSGHVHSVVSSPDGQYLFA 171 >1RI6-A nrPDB Length = 343 Score = 34.3 bits (77), Expect = 0.075, Method: Composition-based stats. Identities = 32/253 (12%), Positives = 74/253 (29%), Gaps = 34/253 (13%) Query: 46 LLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTS------------ 93 +A+ Q + ++++ + G V + D R++ Sbjct: 8 YIASPESQQIHVWNLNHEGALTLTQVVDVPGQVQPMVVSPDKRYLYVGVRPEFRVLAYRI 67 Query: 94 -SEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTH 152 +DG + ++P + H + H Q + GN+ + L + Sbjct: 68 APDDGALTF--AAESALPGSLTHISTD-----HQGQFVFVGSYNAGNVSVTRLEDGLPVG 120 Query: 153 QLTPEDD-TSLQSLSMASDGSML-AAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYI 210 + + S +++ D L A + ++ + + P Sbjct: 121 VVDVVEGLDGCHSANISPDNRTLWVPALKQDRICLFTVSDDGHLVAQDPAEVTTVEGAGP 180 Query: 211 TRILLSSDVKHLAT-CSADHTARVWSIDDDF---KLETTLD------GHQRWVWDCAFSA 260 ++ + ++ + + VW + D + TLD RW D + Sbjct: 181 RHMVFHPNEQYAYCVNELNSSVDVWELKDPHGNIECVQTLDMMPENFSDTRWAADIHITP 240 Query: 261 DSAYLVTASSDHY 273 D +L D Sbjct: 241 DGRHLYAC--DRT 251 >6FYY-p nrPDB Length = 763 Score = 33.1 bits (74), Expect = 0.14, Method: Composition-based stats. Identities = 22/120 (18%), Positives = 42/120 (35%), Gaps = 10/120 (8%) Query: 138 GNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHL 197 W+ N+ + ++ S + + G+ L + + +G W PN Sbjct: 209 KTSVFWNSMFNEEDSLVESRENWSTNYVRFSPKGTYLFSYHQQG-VTAWGGPNFDRLRRF 267 Query: 198 KPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCA 257 H + +S + K+L T S + V ++ +GHQ +WD A Sbjct: 268 Y-------HPD-VRNSSVSPNEKYLVTFSTEPII-VEEDNEFSPFTKKNEGHQLCIWDIA 318 >5SUM-A nrPDB Length = 468 Score = 32.7 bits (73), Expect = 0.19, Method: Composition-based stats. Identities = 23/148 (15%), Positives = 43/148 (29%), Gaps = 23/148 (15%) Query: 102 WDVRSPSIPRNYKH-NAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDT 160 W + + +H P ++ + PN+ L + ++D L Sbjct: 281 WSHLTK---YSTQHGRKPFAQIDLLPNREPL------SQMEVFDAKGENVVSSLGNFQSE 331 Query: 161 SLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVK 220 + L++ T V++ + STYI D K Sbjct: 332 TFNELNV---------ITTDYKKNVFKFDGNGRMLGKVGRDDITGSSTYI----HVHDGK 378 Query: 221 HLATCSADHTARVWSIDDDFKLETTLDG 248 +L D R++ I + L G Sbjct: 379 YLLQGGLDRYVRIFDIKTNKMLVKVYVG 406 Score = 32.3 bits (72), Expect = 0.27, Method: Composition-based stats. Identities = 12/31 (38%), Positives = 19/31 (61%), Gaps = 1/31 (3%) Query: 261 DSAYLVTASSDHYVRLWDLSTRE-IVRQYGG 290 D YL+ D YVR++D+ T + +V+ Y G Sbjct: 376 DGKYLLQGGLDRYVRIFDIKTNKMLVKVYVG 406 >3AZQ-A nrPDB Length = 662 Score = 32.7 bits (73), Expect = 0.19, Method: Composition-based stats. Identities = 27/169 (15%), Positives = 53/169 (31%), Gaps = 29/169 (17%) Query: 75 RGNVTSVS--FQQDN-----RWMVTSSEDGTIKVWDVRSPSIPRNYKHNAP--VNEVVIH 125 RG V ++ F + R++ DG+ S R +A V + Sbjct: 141 RGEVWCMAEEFTGEGPSDVRRFLAAVPLDGSA----AADRSAVRELSDDAHRFVTGPRLS 196 Query: 126 PNQGELISCDRDGNIRIWDLGENQC-----------THQLTPEDDTSLQSLSMASDGSML 174 P+ + + D W+ E + T L + ++ A DGS++ Sbjct: 197 PDGRQAVWLAWDHPRMPWEGTELKTARVTEDGRFADTRTLLGGPEEAIAQAEWAPDGSLI 256 Query: 175 AAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLA 223 A + G + + T A+ + L + ++ A Sbjct: 257 VATDRTGWWNLHRVDPATGAATQLCRRE-----EEFAGPLWTPGMRWFA 300 >4U1F-A nrPDB Length = 497 Score = 32.0 bits (71), Expect = 0.33, Method: Composition-based stats. Identities = 22/120 (18%), Positives = 42/120 (35%), Gaps = 10/120 (8%) Query: 138 GNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHL 197 W+ N+ + ++ S + + G+ L + + +G W PN Sbjct: 41 KTSVFWNSMFNEEDSLVESRENWSTNYVRFSPKGTYLFSYHQQG-VTAWGGPNFDRLRRF 99 Query: 198 KPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCA 257 H + +S + K+L T S + V ++ +GHQ +WD A Sbjct: 100 Y-------HPD-VRNSSVSPNEKYLVTFSTEPII-VEEDNEFSPFTKKNEGHQLCIWDIA 150 >3MWP-A nrPDB Length = 577 Score = 31.2 bits (69), Expect = 0.63, Method: Composition-based stats. Identities = 17/90 (18%), Positives = 33/90 (36%), Gaps = 10/90 (11%) Query: 30 HSDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEG---------HRGNVTS 80 S + +T+D L+ A + ++ IRT P + G R + Sbjct: 92 QQKSILRVGTLTSDDLLILAADLEKLKSKVIRTERPLSAGVYMGNLSSQQLDQRRALLNM 151 Query: 81 VSFQQDNRWMVTSSEDGTIKVWDVRSPSIP 110 + + DG ++VWDV++ + Sbjct: 152 IGMS-GGNQGARAGRDGVVRVWDVKNAELL 180 >2EEP-A nrPDB Length = 706 Score = 30.4 bits (67), Expect = 0.89, Method: Composition-based stats. Identities = 22/136 (16%), Positives = 48/136 (35%), Gaps = 16/136 (11%) Query: 54 NVRLYDIRTTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSED-----GTIKVWDVRSPS 108 V +Y + T + + E +T++S+ D + + + + +D + Sbjct: 236 TVGIYHLATGKTVYLQTGEPKEKFLTNLSWSPDENILYVAEVNRAQNECKVNAYDAETGR 295 Query: 109 IPRNY-----KHN-APVNEVVIHP--NQGELISCDRDG--NIRIWDLGENQCTHQLTPED 158 R KH P++ + P N + RDG ++ ++D + Q+T + Sbjct: 296 FVRTLFVETDKHYVEPLHPLTFLPGSNNQFIWQSRRDGWNHLYLYD-TTGRLIRQVTKGE 354 Query: 159 DTSLQSLSMASDGSML 174 G+ L Sbjct: 355 WEVTNFAGFDPKGTRL 370 Score = 28.9 bits (63), Expect = 2.7, Method: Composition-based stats. Identities = 21/136 (15%), Positives = 43/136 (31%), Gaps = 8/136 (5%) Query: 139 NIRIWDLGENQCTHQLTPE-DDTSLQSLSMASDGSMLAAAN---TKGNCYVWEMPNHTDA 194 + I+ L + + T E + L +LS + D ++L A + C V T Sbjct: 236 TVGIYHLATGKTVYLQTGEPKEKFLTNLSWSPDENILYVAEVNRAQNECKVNAYDAETGR 295 Query: 195 SHLKPVTKFRAH-STYITRILLSS--DVKHLATCSADHTARVWSIDDDFKLETTLDGHQR 251 + H + + + + + D ++ D +L + + Sbjct: 296 FVRTLFVETDKHYVEPLHPLTFLPGSNNQFIWQSRRDGWNHLYLYDTTGRLIRQVTKGEW 355 Query: 252 WVWDCA-FSADSAYLV 266 V + A F L Sbjct: 356 EVTNFAGFDPKGTRLY 371 >6IGR-A nrPDB Length = 656 Score = 30.4 bits (67), Expect = 0.93, Method: Composition-based stats. Identities = 25/168 (14%), Positives = 50/168 (29%), Gaps = 24/168 (14%) Query: 20 LTGVCSRTIQHSDSQVNRLEITNDKKLLA-TAGHQNVRLYDIRTTNPNPVASFEGHRGNV 78 L G +R + H + V+ + + D + +A T D R Sbjct: 111 LKGGEARRVTHFKNGVSGPQWSPDGRFIAFTTTADTEDKRDERGEARVLTRPVY----RA 166 Query: 79 TSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQ-GELISCDRD 137 + + + ++DV + + Y + + P+ G LI D Sbjct: 167 NGADWLPERP--------AALWLYDVEADKLREWYAPEIGIGALSWWPDSRGVLIVQSED 218 Query: 138 ------GNIRIWDLGENQCTHQLTPED----DTSLQSLSMASDGSMLA 175 ++DL P+ +++ L+ DG A Sbjct: 219 EWQASQWRQDVYDLPLPTADAPAAPQKLLDWNSAAHGLAPHPDGQRFA 266 >1YIQ-A nrPDB Length = 689 Score = 30.0 bits (66), Expect = 1.1, Method: Composition-based stats. Identities = 9/83 (10%), Positives = 20/83 (24%) Query: 94 SEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQ 153 S G + WD + N + + DG + + + + Sbjct: 452 SWSGKLIAWDPVKQQAAWEVPYVTIFNGGTLSTAGNLVFEGSADGRVIAYAADTGEKLWE 511 Query: 154 LTPEDDTSLQSLSMASDGSMLAA 176 ++ + DG Sbjct: 512 QPAASGVMAAPVTYSVDGEQYVT 534 Score = 28.5 bits (62), Expect = 3.6, Method: Composition-based stats. Identities = 20/98 (20%), Positives = 31/98 (31%), Gaps = 7/98 (7%) Query: 170 DGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADH 229 +G + A + G W+ A + VT F + LS+ + SAD Sbjct: 444 EGLLEMAKSWSGKLIAWDPVKQQAAWEVPYVTIFNGGT-------LSTAGNLVFEGSADG 496 Query: 230 TARVWSIDDDFKLETTLDGHQRWVWDCAFSADSAYLVT 267 ++ D KL +S D VT Sbjct: 497 RVIAYAADTGEKLWEQPAASGVMAAPVTYSVDGEQYVT 534 >5JN2-A nrPDB Length = 525 Score = 29.7 bits (65), Expect = 1.5, Method: Composition-based stats. Identities = 17/77 (22%), Positives = 25/77 (32%), Gaps = 3/77 (3%) Query: 112 NYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDG 171 Y H + + P L S +D NIRI D G + D + +A + Sbjct: 181 TYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPE- 239 Query: 172 SMLAAANTKGNCYVWEM 188 + C VW Sbjct: 240 --VLHGTYDEKCDVWST 254 >3MA6-A nrPDB Length = 298 Score = 29.7 bits (65), Expect = 1.5, Method: Composition-based stats. Identities = 17/77 (22%), Positives = 25/77 (32%), Gaps = 3/77 (3%) Query: 112 NYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDG 171 Y H + + P L S +D NIRI D G + D + +A + Sbjct: 146 TYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPE- 204 Query: 172 SMLAAANTKGNCYVWEM 188 + C VW Sbjct: 205 --VLHGTYDEKCDVWST 219 >3HFQ-A nrPDB Length = 347 Score = 29.3 bits (64), Expect = 2.0, Method: Composition-based stats. Identities = 36/224 (16%), Positives = 81/224 (36%), Gaps = 18/224 (8%) Query: 78 VTSVSFQQDNRWMVTSSEDGTIKVWDVR--SPSIPRNYKHNAPVNEVVIHPNQGELISCD 135 V S ++ + ++ + DG + + D S PR + + ++ + P+ + Sbjct: 100 VYSANYHKGTAEVMKIAADGALTLTDTVQHSGHGPRPEQDGSHIHYTDLTPDNRLAVIDL 159 Query: 136 RDGNIRIWDLGENQCTHQ---LTPEDDTSLQSLSMASDGSM-LAAANTKGNCYVWEMPNH 191 + ++++ + + LT E + L + DG A + Sbjct: 160 GSDKVYVYNVSDAGQLSEQSVLTMEAGFGPRHLVFSPDGQYAFLAGELSSQIASLKYDTQ 219 Query: 192 TDASHLKPVTK-----FRAHSTYITRILLSSDVKHLATCSAD-HTARVWSI--DDDFKLE 243 T A + K + AH+ I LS D L + +T V+++ D L Sbjct: 220 TGAFTQLGIVKTIPADYTAHNGAA-AIRLSHDGHFLYVSNRGYNTLAVFAVTADGHLTLI 278 Query: 244 TTLDGHQRWVWDCAFSADSAYLVTA--SSDH-YVRLWDLSTREI 284 + + D A++V ++D+ + DL++ ++ Sbjct: 279 QQISTEGDFPRDFDLDPTEAFVVVVNQNTDNATLYARDLTSGKL 322 >1SM3-L nrPDB Length = 215 Score = 28.9 bits (63), Expect = 2.7, Method: Composition-based stats. Identities = 19/109 (17%), Positives = 31/109 (28%), Gaps = 1/109 (0%) Query: 142 IWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVT 201 W G L E + +L L C + + K Sbjct: 97 HWVFGGGTKLTVLGSEKSSPSVTL-FPPSSEELETNKATLVCTITDFYPGVVTVDWKVDG 155 Query: 202 KFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQ 250 T+ S+ K++A+ TAR W + + T +GH Sbjct: 156 TPVTQGMETTQPSKQSNNKYMASSYLTLTARAWERHSSYSCQVTHEGHT 204 >4MF9-A nrPDB Length = 360 Score = 28.9 bits (63), Expect = 2.9, Method: Composition-based stats. Identities = 16/72 (22%), Positives = 28/72 (38%), Gaps = 19/72 (26%) Query: 53 QNVRLYDIRTTNPNPVASFEG-------HRGNVTSVSFQQD---------NRWMVTSSED 96 +L++ + P+ F G H G V ++ + D N + T+ Sbjct: 247 DLAKLFEAAAESGLPIMVFVGNAHCIQIHTGPVCNLKWLDDWFNVLDPEFNLHLKTT--- 303 Query: 97 GTIKVWDVRSPS 108 G ++W VR PS Sbjct: 304 GIAELWRVRKPS 315 >2Z8G-A nrPDB Length = 549 Score = 28.5 bits (62), Expect = 3.9, Method: Composition-based stats. Identities = 34/222 (15%), Positives = 67/222 (30%), Gaps = 18/222 (8%) Query: 71 FEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHPNQGE 130 H +V ++ SS + + + S + P Y + + V P Sbjct: 88 LYSHDA---TVKISRNG-----SSANSNVVI-RPTSLNFPVRYDNQSVYITVPYSPTGYR 138 Query: 131 LISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPN 190 D I + G Q + L S + GS + A G + Sbjct: 139 FSVEFDDDLISLAPSGARQPENALLIFASPFENSSTKPQPGSPNSIAPAPGRVLGLNTTS 198 Query: 191 HTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSA-DHTARVWSIDDDFKL--ETTLD 247 + V F H + + S + A + S + K L Sbjct: 199 ASTVVFNPGVYYFTGHDHMV--LSSSVTWVYFAPGAYVKGAVEFLSTASEVKASGHGVLS 256 Query: 248 GHQRWVWDCAFSADSAY-LVTASSDHYVRLWDLSTREIVRQY 288 G +++VW D Y + ++++ +R+W + + + Sbjct: 257 G-EQYVWYAD--PDEGYQKASGANNNGLRMWRGTLGNSSQTF 295 >4H0U-A nrPDB Length = 266 Score = 28.5 bits (62), Expect = 4.1, Method: Composition-based stats. Identities = 10/46 (21%), Positives = 19/46 (41%), Gaps = 1/46 (2%) Query: 234 WSIDDDFKLETTLDGHQRWVWD-CAFSADSAYLVTASSDHYVRLWD 278 + +++ F L TT H V + V D+ +R+W+ Sbjct: 39 FDLNEGFPLLTTKKVHFHSVVGELLWFLQGDSNVKWLQDNNIRIWN 84 >1Q0Y-L nrPDB Length = 212 Score = 27.7 bits (60), Expect = 5.8, Method: Composition-based stats. Identities = 15/84 (17%), Positives = 26/84 (30%) Query: 167 MASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCS 226 L+ A C + + K T+ S+ K++A+ Sbjct: 121 FPPSSEELSTAKATLVCTITDFYPGVVTVDWKVDGTPVTAGMETTQPSKQSNNKYMASSY 180 Query: 227 ADHTARVWSIDDDFKLETTLDGHQ 250 TAR W + + T +GH Sbjct: 181 LTLTARAWERHSSYSCQVTHEGHS 204 >1OI2-A nrPDB Length = 366 Score = 27.7 bits (60), Expect = 6.3, Method: Composition-based stats. Identities = 8/20 (40%), Positives = 12/20 (60%) Query: 3 VILVSAGYDHTIRFWEALTG 22 +LV+ Y T+RFW+ G Sbjct: 251 TLLVNGSYHRTLRFWDYQQG 270 >1JN6-A nrPDB Length = 210 Score = 27.3 bits (59), Expect = 8.3, Method: Composition-based stats. Identities = 10/34 (29%), Positives = 17/34 (50%) Query: 217 SDVKHLATCSADHTARVWSIDDDFKLETTLDGHQ 250 S+ K++A+ TAR W + + T +GH Sbjct: 171 SNNKYMASSYLTLTARAWERHSSYSCQVTHEGHT 204 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.312 0.133 0.369 Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 11,826,177 Number of Sequences: 36641 Number of extensions: 413934 Number of successful extensions: 6715 Number of sequences better than 10.0: 180 Number of HSP's better than 10.0 without gapping: 265 Number of HSP's successfully gapped in prelim test: 57 Number of HSP's that attempted gapping in prelim test: 1158 Number of HSP's gapped (non-prelim): 1625 length of query: 303 length of database: 10,336,785 effective HSP length: 97 effective length of query: 206 effective length of database: 6,782,608 effective search space: 1397217248 effective search space used: 1397217248 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 59 (27.3 bits)