BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P41091 (472 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 6O81-S nrPDB 956 0.0 6FEC-S nrPDB 860 0.0 3J81-k nrPDB 689 0.0 1S0U-A nrPDB 405 e-113 2D74-A nrPDB 370 e-103 3PEN-A nrPDB 335 2e-92 5IZL-A nrPDB 93 3e-19 5LZD-z nrPDB 92 6e-19 1D2E-A nrPDB 91 1e-18 5W7Q-A nrPDB 86 4e-17 4V5G-AZ nrPDB 85 8e-17 4ZV4-A nrPDB 81 9e-16 5W76-A nrPDB 81 9e-16 1MJ1-A nrPDB 81 1e-15 4J0Q-A nrPDB 81 1e-15 3MMP-A nrPDB 80 2e-15 5W75-A nrPDB 80 2e-15 1EFM-A nrPDB 78 7e-15 6MIJ-A nrPDB 75 6e-14 4AC9-A nrPDB 71 9e-13 3WXM-A nrPDB 69 3e-12 1JNY-A nrPDB 68 8e-12 4ZU9-A nrPDB 67 2e-11 2HDN-B nrPDB 65 8e-11 3WY9-A nrPDB 64 1e-10 3J4J-A nrPDB 51 1e-06 4B44-A nrPDB 51 1e-06 4KJZ-A nrPDB 50 1e-06 4D61-i nrPDB 50 2e-06 5LZT-jj nrPDB 50 3e-06 2B7C-A nrPDB 49 7e-06 1ZUN-B nrPDB 47 2e-05 1R5O-A nrPDB 46 3e-05 4C0S-A nrPDB 46 3e-05 2YWH-A nrPDB 45 5e-05 5LZS-jj nrPDB 45 9e-05 4V6V-A1 nrPDB 42 7e-04 3MCA-A nrPDB 41 9e-04 5FG3-A nrPDB 41 0.001 1G7S-A nrPDB 41 0.001 5YT0-A nrPDB 40 0.002 5LZY-jj nrPDB 39 0.003 2P8Y-T nrPDB 37 0.014 5KCS-1w nrPDB 37 0.023 3P27-A nrPDB 37 0.027 3WNB-A nrPDB 36 0.032 3IZQ-1 nrPDB 36 0.033 2LKD-A nrPDB 35 0.093 5IMR-C nrPDB 34 0.11 5J8B-z nrPDB 34 0.11 3CB4-D nrPDB 34 0.18 4V6W-Az nrPDB 33 0.23 6GB2-BC nrPDB 33 0.24 4CRN-P nrPDB 33 0.26 3JCN-b nrPDB 32 0.72 1ZO1-I nrPDB 32 0.75 1MKY-A nrPDB 31 0.91 3IZY-P nrPDB 31 1.0 2R00-A nrPDB 31 1.1 3I8B-A nrPDB 30 2.7 3K53-A nrPDB 29 3.9 6AK1-A nrPDB 29 4.8 4A9A-A nrPDB 28 5.8 1QVJ-A nrPDB 28 6.6 3HPD-A nrPDB 28 7.6 >6O81-S nrPDB Length = 472 Score = 956 bits (2472), Expect = 0.0, Method: Compositional matrix adjust. Identities = 470/472 (99%), Positives = 470/472 (99%) Query: 1 MAGGEAGVTLGQPHLSRQDLTTLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKA 60 MAGGEAGVTLGQPHLSRQDLTTLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKA Sbjct: 1 MAGGEAGVTLGQPHLSRQDLTTLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKA 60 Query: 61 ISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGT 120 ISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGT Sbjct: 61 ISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGT 120 Query: 121 KGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIM 180 KGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIM Sbjct: 121 KGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIM 180 Query: 181 KLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIV 240 KLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIV Sbjct: 181 KLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIV 240 Query: 241 KKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGI 300 KKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGI Sbjct: 241 KKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGI 300 Query: 301 VSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGA 360 VSK SEGKLMCKP FSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGA Sbjct: 301 VSKASEGKLMCKPKFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGA 360 Query: 361 VGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAV 420 VGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAV Sbjct: 361 VGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAV 420 Query: 421 KADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQIRRGVTIKPTVDDD 472 KADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQIRRGVTIKPTVDDD Sbjct: 421 KADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQIRRGVTIKPTVDDD 472 >6FEC-S nrPDB Length = 422 Score = 860 bits (2223), Expect = 0.0, Method: Compositional matrix adjust. Identities = 422/422 (100%), Positives = 422/422 (100%) Query: 39 QATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPR 98 QATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPR Sbjct: 1 QATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPR 60 Query: 99 PECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLL 158 PECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLL Sbjct: 61 PECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLL 120 Query: 159 IAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEG 218 IAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEG Sbjct: 121 IAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEG 180 Query: 219 APIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGV 278 APIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGV Sbjct: 181 APIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGV 240 Query: 279 AGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIG 338 AGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIG Sbjct: 241 AGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIG 300 Query: 339 VGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKL 398 VGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKL Sbjct: 301 VGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKL 360 Query: 399 SKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQ 458 SKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQ Sbjct: 361 SKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQ 420 Query: 459 IR 460 IR Sbjct: 421 IR 422 >3J81-k nrPDB Length = 527 Score = 689 bits (1778), Expect = 0.0, Method: Compositional matrix adjust. Identities = 328/444 (73%), Positives = 383/444 (86%), Gaps = 1/444 (0%) Query: 24 DVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGY 83 D +KL PLS E+I+RQATINIGTIGHVAHGKSTVV+AISGV TVRFK+ELERNITIKLGY Sbjct: 83 DFSKLNPLSAEIINRQATINIGTIGHVAHGKSTVVRAISGVQTVRFKDELERNITIKLGY 142 Query: 84 ANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMA 143 ANAKIYK +P+CP P+CYRS S PG G +KLVRHVSFVDCPGHDILM+ Sbjct: 143 ANAKIYKCQEPTCPEPDCYRSFKSDKEISPKCQRPGCPGRYKLVRHVSFVDCPGHDILMS 202 Query: 144 TMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQ 203 TML+GAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKH++ILQNK+DL++E A E Sbjct: 203 TMLSGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHVIILQNKVDLMREESALEH 262 Query: 204 YEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFD 263 + IL F++GT+A+GAPI+PISAQLKYNI+ V E+IVK IPVPPRDF PRLIVIRSFD Sbjct: 263 QKSILKFIRGTIADGAPIVPISAQLKYNIDAVNEFIVKTIPVPPRDFMISPRLIVIRSFD 322 Query: 264 VNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFA 323 VNKPG E++DLKGGVAGGSIL GV K+G EIE+RPGIV+KD +GK+ CKPIFS IVSLFA Sbjct: 323 VNKPGAEIEDLKGGVAGGSILNGVFKLGDEIEIRPGIVTKDDKGKIQCKPIFSNIVSLFA 382 Query: 324 EHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLG 383 E NDL++A PGGLIGVGTK+DPTLCRADR+VGQV+GA G LP I+T++EI+YFLLRRLLG Sbjct: 383 EQNDLKFAVPGGLIGVGTKVDPTLCRADRLVGQVVGAKGHLPNIYTDIEINYFLLRRLLG 442 Query: 384 VRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIAL 443 V+T+G K+ AKV+KL NEVLMVNIGS +TG RV AVKAD+ ++ LT+P CTE+ EKIAL Sbjct: 443 VKTDGQKQ-AKVRKLEPNEVLMVNIGSTATGARVVAVKADMARLQLTSPACTEINEKIAL 501 Query: 444 SRRVEKHWRLIGWGQIRRGVTIKP 467 SRR+EKHWRLIGW I++G T++P Sbjct: 502 SRRIEKHWRLIGWATIKKGTTLEP 525 >1S0U-A nrPDB Length = 408 Score = 405 bits (1042), Expect = e-113, Method: Compositional matrix adjust. Identities = 214/425 (50%), Positives = 288/425 (67%), Gaps = 22/425 (5%) Query: 36 ISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPS 95 + QA +NIG +GHV HGK+++ KA++GV T R EL R I+I+LGYA+ +I K Sbjct: 3 LGSQAEVNIGMVGHVDHGKTSLTKALTGVWTDRHSEELRRGISIRLGYADCEIRK----- 57 Query: 96 CPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAA 155 CP+ CG+ T P + +R VSFVD PGH+ LMATML+GA++MD A Sbjct: 58 CPQ------CGTYTTKP---RCPNCLAETEFLRRVSFVDSPGHETLMATMLSGASLMDGA 108 Query: 156 LLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTV 215 +L+IA NE CPQPQT EHL A+EI+ + I+I+QNKIDLV E QA+E YEQI FV+GT+ Sbjct: 109 ILVIAANEPCPQPQTKEHLMALEILGIDKIIIVQNKIDLVDEKQAEENYEQIKEFVKGTI 168 Query: 216 AEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLK 275 AE APIIPISA + NI+V+ + I IP P RD + PR+ V RSFD+NKPG E+ DLK Sbjct: 169 AENAPIIPISAHHEANIDVLLKAIQDFIPTPKRDPDATPRMYVARSFDINKPGTEIKDLK 228 Query: 276 GGVAGGSILKGVLKVGQEIEVRPGIVSKDSEG-KLMCKPIFSKIVSLFAEHNDLQYAAPG 334 GGV GG+I++GV KVG EIE+RPGI K +EG K KP+ +KIVSL A + L+ A PG Sbjct: 229 GGVLGGAIIQGVFKVGDEIEIRPGI--KVTEGNKTFWKPLTTKIVSLAAGNTILRKAHPG 286 Query: 335 GLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAK 394 GLIGVGT +DP L ++D + G V+G G LP I ++ I LL R++G + E K Sbjct: 287 GLIGVGTTLDPYLTKSDALTGSVVGLPGTLPPIREKITIRANLLDRVVGTKEE-----LK 341 Query: 395 VQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLI 454 ++ L EVLM+NIG+ +T G +++ + D+ I L P+C E+G+++A+SRRV WRLI Sbjct: 342 IEPLRTGEVLMLNIGTATTAGVITSARGDIADIKLKLPICAEIGDRVAISRRVGSRWRLI 401 Query: 455 GWGQI 459 G+G I Sbjct: 402 GYGTI 406 >2D74-A nrPDB Length = 419 Score = 370 bits (950), Expect = e-103, Method: Compositional matrix adjust. Identities = 198/431 (45%), Positives = 279/431 (64%), Gaps = 34/431 (7%) Query: 37 SRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDD--- 93 +RQA +NIG +GHV HGK+T+ KA++GV T EL R ITIK+G+A+A+I + + Sbjct: 7 TRQAEVNIGMVGHVDHGKTTLTKALTGVWTDTHSEELRRGITIKIGFADAEIRRCSNCGR 66 Query: 94 ----PSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGA 149 P CP CG T + +R VSF+D PGH+ LM TML GA Sbjct: 67 YSTSPICP------YCGHET---------------EFIRRVSFIDSPGHEALMTTMLAGA 105 Query: 150 AVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILA 209 ++MD A+L+IA NE CP+PQT EHL A++I+ K+I+I QNKI+LV + +A E Y QI Sbjct: 106 SLMDGAILVIAANEPCPRPQTREHLMALQIIGQKNIIIAQNKIELVDKEKALENYRQIKE 165 Query: 210 FVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGC 269 F++GTVAE APIIPISA NI+V+ + I + IP P RD P+++V+RSFDVNKPG Sbjct: 166 FIKGTVAENAPIIPISALHGANIDVLVKAIEEFIPTPKRDSNKPPKMLVLRSFDVNKPGT 225 Query: 270 EVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQ 329 + L GGV GSI++G LKVG EIE+RPG V + G++ +PI ++IVSL A ++ Sbjct: 226 PPEKLVGGVLDGSIVQGKLKVGDEIEIRPG-VPYEEHGRIKYEPITTEIVSLQAGGQFVE 284 Query: 330 YAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGD 389 A PGGL+G+GTK+DP L + D M G V+G G LP ++T+L + LL R++G E Sbjct: 285 EAYPGGLVGIGTKLDPYLTKGDLMAGNVVGKPGKLPPVWTDLRLEVHLLERVVGTEQE-- 342 Query: 390 KKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEK 449 V+ + + EVL++N+G+ T G V+A+ D ++ L PVC E GE++A+SR++ Sbjct: 343 ---LNVEPIKRKEVLLLNVGTARTMGLVTALGKDEIELKLQIPVCAEPGERVAISRQIGS 399 Query: 450 HWRLIGWGQIR 460 WRLIG+G I+ Sbjct: 400 RWRLIGYGIIK 410 >3PEN-A nrPDB Length = 403 Score = 335 bits (860), Expect = 2e-92, Method: Compositional matrix adjust. Identities = 180/425 (42%), Positives = 266/425 (62%), Gaps = 33/425 (7%) Query: 39 QATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPR 98 Q +NIG +GHV HGK+T+V+AI+G+ T + KLGYA I + SC + Sbjct: 6 QPEVNIGVVGHVDHGKTTLVQAITGIWTSK-----------KLGYAETNIGVCE--SCKK 52 Query: 99 PECY---RSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAA 155 PE Y SC S D+ P K +R +SF+D PGH++LMATML+GAA+MD A Sbjct: 53 PEAYVTEPSCKSCGSDDEP----------KFLRRISFIDAPGHEVLMATMLSGAALMDGA 102 Query: 156 LLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTV 215 +L++A NE PQPQT EH A+ I+ +K+++I+QNK+D+V + +A QY QI F +GT Sbjct: 103 ILVVAANEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSKEEALSQYRQIKQFTKGTW 162 Query: 216 AEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLK 275 AE PIIP+SA K NI+ + E I + I P RD + +P ++VIRSFDVNKPG + ++LK Sbjct: 163 AENVPIIPVSALHKINIDSLIEGIEEYIKTPYRDLSQKPVMLVIRSFDVNKPGTQFNELK 222 Query: 276 GGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGG 335 GGV GGSI++G+ KV QEI+V PG+ + +GK+ +PIF+KI S+ + + A PGG Sbjct: 223 GGVIGGSIIQGLFKVDQEIKVLPGL-RVEKQGKVSYEPIFTKISSIRFGDEEFKEAKPGG 281 Query: 336 LIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKV 395 L+ +GT +DP+L +AD ++G ++ A + + I Y LL R++G K+ KV Sbjct: 282 LVAIGTYLDPSLTKADNLLGSIITLADAEVPVLWNIRIKYNLLERVVGA-----KEMLKV 336 Query: 396 QKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGE-KIALSRRVEKHWRLI 454 + E LM+++GS +T G V++VK D ++ L PV + +SR++ WR+I Sbjct: 337 DPIRAKETLMLSVGSSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQIAGRWRMI 396 Query: 455 GWGQI 459 GWG + Sbjct: 397 GWGLV 401 >5IZL-A nrPDB Length = 616 Score = 92.8 bits (229), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 91/339 (26%), Positives = 154/339 (45%), Gaps = 54/339 (15%) Query: 28 LTPLSHEVISRQATINIGTIGHVAHGKSTVVKAISGV-HTVRFKNE---LERNITIKLGY 83 L P + R+ +N+G +GH+ GK+ + +A+S T F + ER IT+ LG+ Sbjct: 14 LVPRGSHMAGRRVNVNVGVLGHIDSGKTALARALSTTASTAAFDKQPQSRERGITLDLGF 73 Query: 84 ANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMA 143 + S P P RS S P EF + + V+ VDCPGH L+ Sbjct: 74 SCF--------SVPLPARLRS---SLP-EFQAAPEAEPEPGEPLLQVTLVDCPGHASLIR 121 Query: 144 TMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQ 203 T++ GA ++D +L+I + Q Q++E L +I K +++L NKIDL+ E + + Sbjct: 122 TIIGGAQIIDLMMLVIDVTKGM-QTQSAECLVIGQIACQKLVVVL-NKIDLLPEGKRQAA 179 Query: 204 YEQILAFVQGTVA----EGAPIIPISA----------QLKYNIEVVCEYIVKKIPVPPRD 249 +++ +Q T+ GAPIIP++A + I + E + +I +P RD Sbjct: 180 IDKMTKKMQKTLENTKFRGAPIIPVAAKPGGPEAPETEAPQGIPELIELLTSQISIPTRD 239 Query: 250 FTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKL 309 + + V F + +G V G+IL G + +G +E+ P + Sbjct: 240 PSGPFLMSVDHCFSIKG--------QGTVMTGTILSGSISLGDSVEI-PAL--------- 281 Query: 310 MCKPIFSKIVSLFAEHNDLQYAAPGGLIGVG-TKIDPTL 347 + K+ S+ H + A G +G+ T+ DP L Sbjct: 282 ---KVVKKVKSMQMFHMPITSAMQGDRLGICVTQFDPKL 317 >5LZD-z nrPDB Length = 614 Score = 91.7 bits (226), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 98/405 (24%), Positives = 177/405 (43%), Gaps = 89/405 (21%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYR 103 I T GHV HGK+T+++AI+GV+ R E +R +TI LGYA P+P+ Sbjct: 3 IATAGHVDHGKTTLLQAITGVNADRLPEEKKRGMTIDLGYA----------YWPQPDGR- 51 Query: 104 SCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNE 163 +PG F+D PGH+ ++ ML G +D ALL++A ++ Sbjct: 52 -------------VPG------------FIDVPGHEKFLSNMLAGVGGIDHALLVVACDD 86 Query: 164 SCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIP 223 QT EHLA +++ + + K D V E++ E Q+ ++ A + Sbjct: 87 GV-MAQTREHLAILQLTGNPMLTVALTKADRVDEARVDEVERQVKEVLREYGFAEAKLFI 145 Query: 224 ISAQLKYNIEVVCEYIVKKIPVPPRDFTSEP--RLIVIRSFDVNKPGCEVDDLKGGVAGG 281 +A ++ + E++++ +P R+ S+ RL + R+F V G V G Sbjct: 146 TAATEGRGMDALREHLLQ---LPEREHASQHSFRLAIDRAFTVKGAGL--------VVTG 194 Query: 282 SILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGT 341 + L G +KVG + + G+ KP+ ++ +L A++ + A G I + Sbjct: 195 TALSGEVKVGDSLWL-TGV----------NKPM--RVRALHAQNQPTETANAGQRIALNI 241 Query: 342 KIDP---TLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKL 398 D + R D ++ V PE FT R ++ ++T L Sbjct: 242 AGDAEKEQINRGDWLLADV------PPEPFT---------RVIVELQTH--------TPL 278 Query: 399 SKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIAL 443 ++ + L ++ + GRVS ++ +L ++V P+ +++ L Sbjct: 279 TQWQPLHIHHAASHVTGRVSLLEDNLAELVFDTPLWLADNDRLVL 323 >1D2E-A nrPDB Length = 397 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 79/267 (29%), Positives = 123/267 (46%), Gaps = 46/267 (17%) Query: 42 INIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPEC 101 +N+GTIGHV HGK+T+ AI+ I + G A K Y+ D + P Sbjct: 4 VNVGTIGHVDHGKTTLTAAIT-------------KILAEGGGAKFKKYEEID-NAPEERA 49 Query: 102 YRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAG 161 ++ E+ T RH + DCPGH + M+ G A +D +L++A Sbjct: 50 RGITINAAHVEYST----------AARHYAHTDCPGHADYVKNMITGTAPLDGCILVVAA 99 Query: 162 NESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYE---QILAFVQGTVAEG 218 N+ P PQT EHL + ++H+++ NK D V++S+ E E + L G E Sbjct: 100 NDG-PMPQTREHLLLARQIGVEHVVVYVNKADAVQDSEMVELVELEIRELLTEFGYKGEE 158 Query: 219 APIIPISAQLKY----------NIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPG 268 PII SA +++ + + + IPVP RD +P L+ + S + PG Sbjct: 159 TPIIVGSALCALEQRDPELGLKSVQKLLDAVDTYIPVPTRDL-EKPFLLPVESV-YSIPG 216 Query: 269 CEVDDLKGGVAGGSILKGVLKVGQEIE 295 +G V G++ +G+LK G E E Sbjct: 217 ------RGTVVTGTLERGILKKGDECE 237 >5W7Q-A nrPDB Length = 373 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 76/267 (28%), Positives = 123/267 (46%), Gaps = 46/267 (17%) Query: 42 INIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPEC 101 +NIGTIGHV HGK+T+ AI+ + K G A AK Y D + P + Sbjct: 6 VNIGTIGHVDHGKTTLTAAIT-------------TVLAKKGGAEAKAYDQID-NAPEEKA 51 Query: 102 YRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAG 161 ++ E+ T+ RH + VDCPGH + M+ GAA MD A+L+++ Sbjct: 52 RGITINTAHVEYETE----------NRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSA 101 Query: 162 NESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPI 221 + P PQT EH+ + + +I++ NK D+V + + E E + + Sbjct: 102 ADG-PMPQTREHILLARQVGVPYIVVFLNKCDMVDDEELLELVEMEVRELLSEYDFPGDD 160 Query: 222 IPI-----------SAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRS-FDVNKPGC 269 IPI A+ + I + + + IP P RD +P L+ I F ++ Sbjct: 161 IPIIRGSALKALEGDAEWEDKILELMDAVDSYIPTPERDI-DKPFLMPIEDVFSISG--- 216 Query: 270 EVDDLKGGVAGGSILKGVLKVGQEIEV 296 +G V G + +G++KVG+E+E+ Sbjct: 217 -----RGTVVTGRVERGIVKVGEEVEI 238 >4V5G-AZ nrPDB Length = 406 Score = 84.7 bits (208), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 97/376 (25%), Positives = 154/376 (40%), Gaps = 67/376 (17%) Query: 34 EVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDD 93 E + + +N+GTIGHV HGK+T+ A++ V N K Y D Sbjct: 5 EFVRTKPHVNVGTIGHVDHGKTTLTAALTYVAAAENPN------------VEVKDYG-DI 51 Query: 94 PSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMD 153 P ++ E+ T RH S VDCPGH + M+ GAA MD Sbjct: 52 DKAPEERARGITINTAHVEYET----------AKRHYSHVDCPGHADYIKNMITGAAQMD 101 Query: 154 AALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQG 213 A+L+++ + P PQT EH+ + + +I++ NK+D+V + + + E + + Sbjct: 102 GAILVVSAADG-PMPQTREHILLARQVGVPYIVVFMNKVDMVDDPELLDLVEMEVRDLLN 160 Query: 214 TV---AEGAPIIPISA-----QLKYN-------------IEVVCEYIVKKIPVPPRDFTS 252 + P+I SA Q+ N I + + I + IP P RD Sbjct: 161 QYEFPGDEVPVIRGSALLALEQMHRNPKTRRGENEWVDKIWELLDAIDEYIPTPVRDVDK 220 Query: 253 EPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCK 312 + V F + +G VA G I +G +KVG E+E IV E + Sbjct: 221 PFLMPVEDVFTITG--------RGTVATGRIERGKVKVGDEVE----IVGLAPETRRTV- 267 Query: 313 PIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELE 372 + + LQ G +GV + + R + GQVL G++ T+ E Sbjct: 268 -----VTGVEMHRKTLQEGIAGDNVGVLLR---GVSREEVERGQVLAKPGSITP-HTKFE 318 Query: 373 ISYFLLRRLLGVRTEG 388 S ++L++ G R G Sbjct: 319 ASVYVLKKEEGGRHTG 334 >4ZV4-A nrPDB Length = 405 Score = 81.3 bits (199), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 94/360 (26%), Positives = 159/360 (44%), Gaps = 66/360 (18%) Query: 42 INIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPEC 101 +N+GTIGHV HGK+T+ A++ V + + +A+ + D + P + Sbjct: 13 VNVGTIGHVDHGKTTLTAALTKVCSDTWG-------------GSARAFDQID-NAPEEKA 58 Query: 102 YRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAG 161 +++ E+ + VRH + VDCPGH + M+ GAA MD A+L+ + Sbjct: 59 RGITINTSHVEYDS----------AVRHYAHVDCPGHADYVKNMITGAAQMDGAILVCSA 108 Query: 162 NESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTV---AEG 218 + P PQT EH+ + + +I++ NK D+V +++ E E + + T + Sbjct: 109 ADG-PMPQTREHILLSRQVGVPYIVVFLNKADMVDDAELLELVEMEVRDLLNTYDFPGDD 167 Query: 219 APIIPISAQLKYN-----------IEVVCEYIVKKIPVPPRDFTSEPRLIVIRS-FDVNK 266 PII SA + ++ + E + IP P R +P L+ I F ++ Sbjct: 168 TPIIIGSALMALEGKDDNGIGVSAVQKLVETLDSYIPEPVRAI-DQPFLMPIEDVFSISG 226 Query: 267 PGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHN 326 +G V G + +G++KV +E+E IV + K C V +F + Sbjct: 227 --------RGTVVTGRVERGIIKVQEEVE----IVGIKATTKTTCTG-----VEMFRKLL 269 Query: 327 DLQYAAPG-GLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVR 385 D A G++ GTK R D GQVL G + + T+ E ++L + G R Sbjct: 270 DEGRAGENVGILLRGTK------REDVERGQVLAKPGTI-KPHTKFECEVYVLSKEEGGR 322 >5W76-A nrPDB Length = 385 Score = 81.3 bits (199), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 96/351 (27%), Positives = 163/351 (46%), Gaps = 52/351 (14%) Query: 42 INIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPEC 101 +NIGTIGHV HGK+T+ AI+ + + G A K Y D + E Sbjct: 5 VNIGTIGHVDHGKTTLTAAIT-------------KVLAEKGQAEFKAYDQIDKAPEEKE- 50 Query: 102 YRSCGSSTPD-EFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIA 160 R ST E+ T+ RH + VDCPGH + M+ GAA MD A+L+++ Sbjct: 51 -RGITISTAHVEYETE----------NRHYAHVDCPGHADYVKNMITGAAQMDGAILVVS 99 Query: 161 GNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTV---AE 217 + P PQT EH+ + + +I++ NK+D+V + + E E + + + + Sbjct: 100 AADG-PMPQTREHILLARQVGVPYIVVFLNKVDMVDDEELLELVEMEVRELLSSYDFPGD 158 Query: 218 GAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDL-KG 276 PII SA + E + K+ + EP + + F + P +V + +G Sbjct: 159 DIPIIKGSALKALEGDEEGEEAIMKLMDAVDSYIPEPERAIDKPFLM--PIEDVFSISRG 216 Query: 277 GVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCK--PIFSKIVSLFAEHNDLQYAAPG 334 V G + +G++KVG+E+E+ + +D++ K C +F K++ ++ Q Sbjct: 217 TVVTGRVERGIVKVGEEVEI---VGIRDTQ-KTTCTGVEMFRKLL------DEGQAGDNV 266 Query: 335 GLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVR 385 G++ GTK R D GQVL G++ + T+ + ++L + G R Sbjct: 267 GVLLRGTK------REDVERGQVLAKPGSI-KPHTKFKAEVYILTKEEGGR 310 >1MJ1-A nrPDB Length = 405 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 92/372 (24%), Positives = 157/372 (42%), Gaps = 59/372 (15%) Query: 34 EVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDD 93 E I + +N+GTIGHV HGK+T+ A++ V RN+ +K D Sbjct: 4 EFIRTKRHVNVGTIGHVDHGKTTLTAALTYVAAAE-----NRNVEVK---------DYGD 49 Query: 94 PSCPRPECYRSCGSSTPD-EFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVM 152 R E R +T E+ T RH S VDC GH + M+ GAA M Sbjct: 50 IDKAREERARGITINTAHVEYET----------AKRHYSHVDCRGHADYIKNMITGAAQM 99 Query: 153 DAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYE-QILAFV 211 D A+L+++ + QT EH+ + +++I++ NK+D+V + + + E ++ + Sbjct: 100 DGAILVVSAADG-RMRQTREHILLARQVGVRYIVVFMNKVDMVDDRELLDLVEMEVRDLL 158 Query: 212 QGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSE--------PRLIVIRSFD 263 G + I +E + + +K ++ + I R D Sbjct: 159 NQYEFRGDEVRVIRGSALLALEEMHKN--RKTKRGENEWVDKIWELLDAIDEYIRTRVRD 216 Query: 264 VNKPG-CEVDDL-----KGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSK 317 V+K V+D+ +G VA G I +G +KVG E+E+ + + Sbjct: 217 VDKRFLMRVEDVFTITGRGTVATGRIERGKVKVGDEVEIVG-----------LARETRKT 265 Query: 318 IVSLFAEHND-LQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYF 376 +V+ H LQ G +G+ + + R + GQVL G++ T+ E S + Sbjct: 266 VVTGVEMHRKTLQEGIAGDNVGL---LLRGVSREEVERGQVLAKRGSITR-HTKFEASVY 321 Query: 377 LLRRLLGVRTEG 388 +L++ G R G Sbjct: 322 ILKKEEGGRHTG 333 >4J0Q-A nrPDB Length = 433 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 74/270 (27%), Positives = 124/270 (45%), Gaps = 49/270 (18%) Query: 42 INIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPEC 101 +N+GTIGHV HGK+T+ A++ V + F G A + K+D S P + Sbjct: 49 VNVGTIGHVDHGKTTLTAALTRVCSEVF------------GSAIVEFDKID--SAPEEKA 94 Query: 102 YRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAG 161 ++ E+ + I RH + VDCPGH + M+ GAA MD A+L+ + Sbjct: 95 RGITINTAHVEYNSTI----------RHYAHVDCPGHADYVKNMITGAAQMDGAILVCSA 144 Query: 162 NESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTV---AEG 218 + P PQT EH+ + + +I++ NK DLV +++ E E + + T + Sbjct: 145 ADG-PMPQTREHILLSRQVGVPYIVVFLNKADLVDDAELLELVEMEVRDLLSTYDFPGDD 203 Query: 219 APIIPISAQLKYN-----------IEVVCEYIVKKIPVPPRDFTSEPRLIVIRS-FDVNK 266 PII SA++ ++ + E + IP P R +P L+ I F ++ Sbjct: 204 TPIIIGSARMALEGKDDNEMGTTAVKKLVETLDSYIPEPVRAI-DQPFLMPIEDVFSISG 262 Query: 267 PGCEVDDLKGGVAGGSILKGVLKVGQEIEV 296 +G V G I +G+++V +E+ Sbjct: 263 --------RGTVVTGRIERGIVRVQDPLEI 284 >3MMP-A nrPDB Length = 678 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 75/288 (26%), Positives = 129/288 (44%), Gaps = 53/288 (18%) Query: 25 VTKLTPLSHEVISR-QATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGY 83 ++K + +S E R + +N+GTIGHV HGK+T+ AI+ V + G Sbjct: 279 MSKQSHMSKEKFERTKPHVNVGTIGHVDHGKTTLTAAITTV------------LAKTYGG 326 Query: 84 ANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMA 143 A ++D+ + S + PT RH + VDCPGH + Sbjct: 327 AARAFDQIDNAPEEKARGITINTSHVEYDTPT------------RHYAHVDCPGHADYVK 374 Query: 144 TMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAK-- 201 M+ GAA MD A+L++A + P PQT EH+ + + +I++ NK D+V + + Sbjct: 375 NMITGAAQMDGAILVVAATDG-PMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLEL 433 Query: 202 ---------EQYE---QILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRD 249 QY+ V+G+ + + A+ + I + ++ IP P R Sbjct: 434 VEMEVRELLSQYDFPGDDTPIVRGSALKA---LEGDAEWEAKILELAGFLDSYIPEPERA 490 Query: 250 FTSEPRLIVIRS-FDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEV 296 +P L+ I F ++ +G V G + +G++KVG+E+E+ Sbjct: 491 I-DKPFLLPIEDVFSISG--------RGTVVTGRVERGIIKVGEEVEI 529 >5W75-A nrPDB Length = 392 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 76/272 (27%), Positives = 124/272 (45%), Gaps = 52/272 (19%) Query: 42 INIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPEC 101 +N+GTIGHV HGKST+ AI+ + +++K G A Y D P + Sbjct: 5 VNVGTIGHVDHGKSTLTAAIT------------KYLSLK-GLAQYVPYDQID-KAPEEKA 50 Query: 102 YRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAG 161 + T E+ T+ RH + +DCPGH + M+ GAA MD A+L++A Sbjct: 51 RGITINITHVEYETE----------KRHYAHIDCPGHADYIKNMITGAAQMDGAILVVAA 100 Query: 162 NESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKE-----------QYE---QI 207 + P PQT EH+ + + ++++ NK D+V + + E QYE Sbjct: 101 TDG-PMPQTREHVLLARQVGVPYMIVFINKTDMVDDPELIELVEMEVRDLLSQYEYPGDE 159 Query: 208 LAFVQGTVAEG--APIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRS-FDV 264 + ++G+ + AP P K I+ + + + IP P RD +P L+ I F + Sbjct: 160 VPVIKGSALKALEAPDDPNHEAYK-PIQELLDAMDNYIPDPQRD-VDKPFLMPIEDVFSI 217 Query: 265 NKPGCEVDDLKGGVAGGSILKGVLKVGQEIEV 296 +G V G I +G ++ G E+E+ Sbjct: 218 TG--------RGTVVTGRIERGRIRPGDEVEI 241 >1EFM-A nrPDB Length = 379 Score = 78.2 bits (191), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 72/270 (26%), Positives = 118/270 (43%), Gaps = 66/270 (24%) Query: 42 INIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPEC 101 +N+GTIGHV HGK+T+ AI+ V + R ITI N + D P+ Sbjct: 12 VNVGTIGHVDHGKTTLTAAITTVLAKTYGGAA-RGITI-----NTSHVEYDTPT------ 59 Query: 102 YRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAG 161 RH + VDCPGH + M+ GAA MD A+L++A Sbjct: 60 --------------------------RHYAHVDCPGHADYVKNMITGAAQMDGAILVVAA 93 Query: 162 NESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAK-----------EQYE---QI 207 + P PQT EH+ + + +I++ NK D+V + + QY+ Sbjct: 94 TDG-PMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDD 152 Query: 208 LAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRS-FDVNK 266 V+G+ + + A+ + I + ++ IP P R +P L+ I F ++ Sbjct: 153 TPIVRGSALKA---LEGDAEWEAKILELAGFLDSYIPEPERAI-DKPFLLPIEDVFSISG 208 Query: 267 PGCEVDDLKGGVAGGSILKGVLKVGQEIEV 296 +G V G + +G++KVG+E+E+ Sbjct: 209 --------RGTVVTGRVERGIIKVGEEVEI 230 >6MIJ-A nrPDB Length = 396 Score = 75.1 bits (183), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 75/260 (28%), Positives = 118/260 (45%), Gaps = 30/260 (11%) Query: 42 INIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPEC 101 +N+GTIGHV HGK+T+ AI+ + + E AK Y D S P + Sbjct: 13 VNVGTIGHVDHGKTTLTAAIATICAKTYGGE-------------AKDYSQID-SAPEEKA 58 Query: 102 YRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAG 161 +++ E+ D P RH + VDCPGH + M+ GAA MD A+L+ A Sbjct: 59 RGITINTSHVEY--DSP--------TRHYAHVDCPGHADYVKNMITGAAQMDGAILVCAA 108 Query: 162 NESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTV---AEG 218 + P PQT EH+ + + +I++ NK DLV + + E E + + T + Sbjct: 109 TDG-PMPQTREHILLSRQVGVPYIIVFLNKCDLVDDEELLELVEMEVRELLSTYDFPGDD 167 Query: 219 APIIPISAQLKYNIEV--VCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKG 276 P+I SA N E E V + + EP + ++F + +G Sbjct: 168 TPVIRGSALAALNGEAGPYGEESVLALVAALDSYIPEPERAIDKAFLMPIEDVFSISGRG 227 Query: 277 GVAGGSILKGVLKVGQEIEV 296 V G + G++KVG+E+E+ Sbjct: 228 TVVTGRVEAGIIKVGEEVEI 247 >4AC9-A nrPDB Length = 482 Score = 71.2 bits (173), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 64/265 (24%), Positives = 122/265 (46%), Gaps = 54/265 (20%) Query: 41 TINIGTIGHVAHGKSTVVKAISGVHTVRFKNEL----ERNITIKLGYANAKIYKLDDPSC 96 IN+G GH+ HGK+T+ K ++ + + ++L +R ITI +G++ K+ Sbjct: 19 NINLGIFGHIDHGKTTLSKVLTEIASTSAHDKLPESQKRGITIDIGFSAFKL-------- 70 Query: 97 PRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAAL 156 E YR ++ VD PGH L+ +++ A ++D AL Sbjct: 71 ---ENYR--------------------------ITLVDAPGHADLIRAVVSAADIIDLAL 101 Query: 157 LLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGT-V 215 +++ E P+ QT EH+ ++ + I+++ K D + K + + +Q T Sbjct: 102 IVVDAKEG-PKTQTGEHMLILDHFNIP-IIVVITKSDNAGTEEIKRTEMIMKSILQSTHN 159 Query: 216 AEGAPIIPISAQLKYNIEVVCEYIVKKIPVPP--RDFTSEPRLIVIRSFDVNKPGCEVDD 273 + + IIPISA+ + ++ + I+ + R+ S ++ + +F + G Sbjct: 160 LKNSSIIPISAKTGFGVDELKNLIITTLNNAEIIRNTESYFKMPLDHAFPIKGAGT---- 215 Query: 274 LKGGVAGGSILKGVLKVGQEIEVRP 298 V G+I KG++KVG E++V P Sbjct: 216 ----VVTGTINKGIVKVGDELKVLP 236 >3WXM-A nrPDB Length = 447 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 101/462 (21%), Positives = 178/462 (38%), Gaps = 136/462 (29%) Query: 36 ISRQATINIGTIGHVAHGKSTVVKAI---------------------SGVHTVRF----- 69 ++ + +N+ IGHV HGKST+V + G + +F Sbjct: 4 MAEKPHMNLVVIGHVDHGKSTLVGHLLYRLGYIEEKKLKELEEQAKSRGKESFKFAWILD 63 Query: 70 --KNELERNITIKLGYANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLV 127 K E ER ITI L + F+ Sbjct: 64 KMKEERERGITIDLTFMK--------------------------------------FETK 85 Query: 128 RHV-SFVDCPGHDILMATMLNGAAVMDAALLLIAGNES------CPQPQTSEHLAAIEIM 180 ++V + +D PGH + M+ GA+ DAA+L+++ + + QT EHL M Sbjct: 86 KYVFTIIDAPGHRDFVKNMITGASQADAAILVVSARKGEFEAGMSTEGQTREHLLLARTM 145 Query: 181 KLKHILILQNKIDLVKESQAKEQYEQILAFVQ------GTVAEGAPIIPISAQL------ 228 ++ I++ NK+D + +++YE +++ ++ G + P IP+SA Sbjct: 146 GIEQIIVAVNKMDAPDVNYDQKRYEFVVSVLKKFMKGLGYQVDKIPFIPVSAWKGDNLIE 205 Query: 229 ------KYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGS 282 YN + E + + P P + R+ V + + PG G V G Sbjct: 206 RSPNMPWYNGPTLVEALDQLQP-PAKPVDKPLRIPVQNVYSI--PGA------GTVPVGR 256 Query: 283 ILKGVLKVGQE-IEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGT 341 + GVL+VG + + + PG+V ++ S+ + LQ A PG IG Sbjct: 257 VETGVLRVGDKVVFMPPGVV--------------GEVRSIEMHYQQLQQAEPGDNIGFAV 302 Query: 342 KIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKN 401 + + ++D G V G + P + E E F++ + + Sbjct: 303 R---GVSKSDIKRGDVAGHLDKPPTVAEEFEARIFVIWHPSAI------------TVGYT 347 Query: 402 EVLMVNIGSLSTGGRVSAVKADL----GKIVLTNPVCTEVGE 439 V+ V+ S+S+ R+ +KA L G++V NP + G+ Sbjct: 348 PVIHVHTASVSS--RIIEIKAKLDPKTGQVVEQNPQFLKAGD 387 >1JNY-A nrPDB Length = 435 Score = 68.2 bits (165), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 89/367 (24%), Positives = 152/367 (41%), Gaps = 72/367 (19%) Query: 36 ISRQATINIGTIGHVAHGKSTVV------KAISGVHTVRFKNELERNITIKLGYANAKIY 89 +S++ +N+ IGHV HGKST+V + TV+ E + KLG + K Sbjct: 1 MSQKPHLNLIVIGHVDHGKSTLVGRLLMDRGFIDEKTVKEAEEAAK----KLGKESEKFA 56 Query: 90 KLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHV-SFVDCPGHDILMATMLNG 148 L D R + R G + I T F+ ++ + +D PGH + M+ G Sbjct: 57 FLLD----RLKEERERGVT--------INLTFMRFETKKYFFTIIDAPGHRDFVKNMITG 104 Query: 149 AAVMDAALLLIAGNES------CPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKE 202 A+ DAA+L+++ + + QT EH+ + M L +++ NK+DL + ++ Sbjct: 105 ASQADAAILVVSAKKGEYEAGMSVEGQTREHIILAKTMGLDQLIVAVNKMDLTEPPYDEK 164 Query: 203 QYEQI-----------------LAFVQGTVAEGAPIIPISAQLK-YNIEVVCEYIVKKIP 244 +Y++I + FV G I S +K YN + EY+ ++ Sbjct: 165 RYKEIVDQVSKFMRSYGFNTNKVRFVPVVAPSGDNITHKSENMKWYNGPTLEEYL-DQLE 223 Query: 245 VPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKD 304 +PP+ R+ + + ++ G V G + GVLKVG +I P Sbjct: 224 LPPKPVDKPLRIPIQDVYSISGVGT--------VPVGRVESGVLKVGDKIVFMPA----- 270 Query: 305 SEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGAL 364 GK+ ++ S+ H + A PG IG + + + D G V+G Sbjct: 271 --GKV------GEVRSIETHHTKMDKAEPGDNIGFNVR---GVEKKDIKRGDVVGHPNNP 319 Query: 365 PEIFTEL 371 P + E Sbjct: 320 PTVADEF 326 >4ZU9-A nrPDB Length = 582 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 71/264 (26%), Positives = 115/264 (43%), Gaps = 47/264 (17%) Query: 42 INIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPEC 101 I T GHV HGK+T++K ++G+ T R E +R ++I +G+A Sbjct: 4 ILFATAGHVDHGKTTLIKTLTGIDTDRLPEEKKRGLSIDIGFAYI--------------- 48 Query: 102 YRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAG 161 +FP DI N +L +D PGH+ + + G +L++ Sbjct: 49 ----------DFP-DI-----NTRL----EIIDVPGHERFIKNAIAGICSASGLILVVDP 88 Query: 162 NESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPI 221 NE PQT EHL + +KH + + K+D V E A E+++AF++ I Sbjct: 89 NEGI-MPQTIEHLRVAKSFGIKHGIAVLTKMDKVDEELAHIAEEELIAFLEKE-EMNMEI 146 Query: 222 IPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEP-RLIVIRSFDVNKPGCEVDDLKGGVAG 280 + +SA IE + I K + +P R+ V +F V G V Sbjct: 147 VKVSAVTGQGIEDLKNSIKKLLESINNLNKHKPLRIFVDSAFVVKGYGT--------VLR 198 Query: 281 GSILKGVLKVGQEIEVRP-GIVSK 303 GS +G +K G ++ V P G++S+ Sbjct: 199 GSCFEGEVKEGDKVVVEPIGVISR 222 >2HDN-B nrPDB Length = 335 Score = 64.7 bits (156), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 51/184 (27%), Positives = 89/184 (48%), Gaps = 28/184 (15%) Query: 128 RHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILI 187 RH + VDCPGH + M+ GAA MD A+L++A + P PQT EH+ + + +I++ Sbjct: 16 RHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDG-PMPQTREHILLGRQVGVPYIIV 74 Query: 188 LQNKIDLVKESQAK-----------EQYE---QILAFVQGTVAEGAPIIPISAQLKYNIE 233 NK D+V + + QY+ V+G+ + + A+ + I Sbjct: 75 FLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKA---LEGDAEWEAKIL 131 Query: 234 VVCEYIVKKIPVPPRDFTSEPRLIVIRS-FDVNKPGCEVDDLKGGVAGGSILKGVLKVGQ 292 + ++ IP P R +P L+ I F ++ +G V G + +G++KVG+ Sbjct: 132 ELAGFLDSYIPEPERAI-DKPFLLPIEDVFSISG--------RGTVVTGRVERGIIKVGE 182 Query: 293 EIEV 296 E+E+ Sbjct: 183 EVEI 186 >3WY9-A nrPDB Length = 434 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 90/351 (25%), Positives = 144/351 (41%), Gaps = 67/351 (19%) Query: 42 INIGTIGHVAHGKSTVVK-------AISGVHTVRFKNELERNITIKLGYANAKIYKLDDP 94 +NI IGHV HGKST + I +F+ E+ + K + ++ + Sbjct: 8 VNIVFIGHVDHGKSTTIGRLLYDTGNIPETIIKKFEEMGEKGKSFKFAWVMDRLKE---- 63 Query: 95 SCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDA 154 R G + D+ TK R+++ +D PGH + M+ GA+ DA Sbjct: 64 -------ERERGITI------DVAHTKFETPH-RYITIIDAPGHRDFVKNMITGASQADA 109 Query: 155 ALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGT 214 A+L++A + PQT EH + +KHI++ NK+D+V Q + +E++ A V+ Sbjct: 110 AVLVVAATDGV-MPQTKEHAFLARTLGIKHIIVTINKMDMVNYDQ--KVFEKVKAQVEKL 166 Query: 215 VA----EGAPIIPISA------------QLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIV 258 + + P+IP SA YN + E + +IP P + R+ Sbjct: 167 LKTLGYKDFPVIPTSAWNGDNVVKKSDKMPWYNGPTLIEAL-DQIPEPEKPIDKPLRI-- 223 Query: 259 IRSFDVNKPGCEVDDLK--GGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFS 316 P +V +K G V G + G LKVG + P + KPI Sbjct: 224 --------PIQDVYSIKGVGTVPVGRVETGKLKVGDVVIFEPA-------STIFHKPIQG 268 Query: 317 KIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEI 367 ++ S+ H LQ A PG IG + + + D G V G P + Sbjct: 269 EVKSIEMHHEPLQEALPGDNIGFNVR---GVSKNDIKRGDVAGHTDKPPTV 316 >3J4J-A nrPDB Length = 569 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 97/213 (45%), Gaps = 27/213 (12%) Query: 130 VSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQ 189 V F+D PGH+ GA V D A+++IA ++ PQT E +A + K I + Sbjct: 122 VVFIDTPGHEAFTTIRQRGAKVADIAVIVIAADDGI-MPQTEEAIAHAKAAGAKLIFAI- 179 Query: 190 NKIDLVKESQAKEQYEQI-LAFVQGTVAEGAPIIPISAQLKYNIEVVCEYI--VKKIPVP 246 NKIDL + K + + + FV A +IPISA+ ++ + E I + ++ Sbjct: 180 NKIDLPQADPEKVKRQLMERGFVPEEYGGDAIVIPISAKTGQGVQDLLEMILLLAELEDY 239 Query: 247 PRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSE 306 D +EPR +++ S ++D G +A + +G +VG +V+ ++ Sbjct: 240 RADPNAEPRGVILES--------KLDKQAGIIANMLVQEGTFRVGDY------VVAGEAY 285 Query: 307 GKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGV 339 G++ + A+ N + A PG + V Sbjct: 286 GRIRA--------MMDADGNQRKEAGPGSAVQV 310 >4B44-A nrPDB Length = 363 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 97/213 (45%), Gaps = 27/213 (12%) Query: 130 VSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQ 189 V F+D PGH+ GA V D A+++IA ++ PQT E +A + K I + Sbjct: 122 VVFIDTPGHEAFTTIRQRGAKVADIAVIVIAADDGI-MPQTEEAIAHAKAAGAKLIFAI- 179 Query: 190 NKIDLVKESQAKEQYEQI-LAFVQGTVAEGAPIIPISAQLKYNIEVVCEYI--VKKIPVP 246 NKIDL + K + + + FV A +IPISA+ ++ + E I + ++ Sbjct: 180 NKIDLPQADPEKVKRQLMERGFVPEEYGGDAIVIPISAKTGQGVQDLLEMILLLAELEDY 239 Query: 247 PRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSE 306 D +EPR +++ S ++D G +A + +G +VG +V+ ++ Sbjct: 240 RADPNAEPRGVILES--------KLDKQAGIIANMLVQEGTFRVGDY------VVAGEAY 285 Query: 307 GKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGV 339 G++ + A+ N + A PG + V Sbjct: 286 GRIRA--------MMDADGNQRKEAGPGSAVQV 310 >4KJZ-A nrPDB Length = 473 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 97/213 (45%), Gaps = 27/213 (12%) Query: 130 VSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQ 189 V F+D PGH+ GA V D A+++IA ++ PQT E +A + K I + Sbjct: 121 VVFIDTPGHEAFTTIRQRGAKVADIAVIVIAADDGI-MPQTEEAIAHAKAAGAKLIFAI- 178 Query: 190 NKIDLVKESQAKEQYEQI-LAFVQGTVAEGAPIIPISAQLKYNIEVVCEYI--VKKIPVP 246 NKIDL + K + + + FV A +IPISA+ ++ + E I + ++ Sbjct: 179 NKIDLPQADPEKVKRQLMERGFVPEEYGGDAIVIPISAKTGQGVQDLLEMILLLAELEDY 238 Query: 247 PRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSE 306 D +EPR +++ S ++D G +A + +G +VG +V+ ++ Sbjct: 239 RADPNAEPRGVILES--------KLDKQAGIIANMLVQEGTFRVGDY------VVAGEAY 284 Query: 307 GKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGV 339 G++ + A+ N + A PG + V Sbjct: 285 GRIRA--------MMDADGNQRKEAGPGSAVQV 309 >4D61-i nrPDB Length = 426 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 47/176 (26%), Positives = 78/176 (44%), Gaps = 25/176 (14%) Query: 42 INIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPEC 101 +N+ IGHV GKST+ I + + K LE+ Y+ + R Sbjct: 4 VNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEK-------------YEREAKEKNRETW 50 Query: 102 YRSCGSSTPDEFPTDIPGT----KGNFKL-VRHVSFVDCPGHDILMATMLNGAAVMDAAL 156 Y S T E D T + F+ +H + +D PGH + M+ GA+ D A+ Sbjct: 51 YLSWALDTNQE-ERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAV 109 Query: 157 LLIAGNESCPQP------QTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQ 206 L+I+ + + QT EH + +KH+++L NK+D + + E+YE+ Sbjct: 110 LVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEE 165 >5LZT-jj nrPDB Length = 637 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 45/178 (25%), Positives = 78/178 (43%), Gaps = 21/178 (11%) Query: 38 RQATINIGTIGHVAHGKSTV---VKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDP 94 ++ +N+ IGHV GKST+ + ++G+ R + ER K + LD Sbjct: 209 KKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTN 268 Query: 95 SCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDA 154 R D+ T G +H + +D PGH + M+ GA+ D Sbjct: 269 QEER------------DKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADL 316 Query: 155 ALLLIAGNESCPQP------QTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQ 206 A+L+I+ + + QT EH + +KH+++L NK+D + + E+YE+ Sbjct: 317 AVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEE 374 >2B7C-A nrPDB Length = 458 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 31/108 (28%), Positives = 53/108 (49%), Gaps = 10/108 (9%) Query: 129 HVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNES------CPQPQTSEHLAAIEIMKL 182 V+ +D PGH + M+ G + D A+L+IAG QT EH + + Sbjct: 86 QVTVIDAPGHRDFIKNMITGTSQADCAILIIAGGVGEFEAGISKDGQTREHALLAFTLGV 145 Query: 183 KHILILQNKIDLVK--ESQAKEQYEQILAFVQ--GTVAEGAPIIPISA 226 + +++ NK+D VK ES+ +E ++ F++ G + P +PIS Sbjct: 146 RQLIVAVNKMDSVKWDESRFQEIVKETSNFIKKVGYNPKTVPFVPISG 193 >1ZUN-B nrPDB Length = 434 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 58/243 (23%), Positives = 97/243 (39%), Gaps = 39/243 (16%) Query: 128 RHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILI 187 R D PGH+ M GA+ D A++L+ Q QT H ++ +KHI++ Sbjct: 104 RKFIIADTPGHEQYTRNMATGASTCDLAIILVDARYGV-QTQTRRHSYIASLLGIKHIVV 162 Query: 188 LQNKIDL------VKESQAKEQYEQI----------LAFVQGTVAEGAPIIPISAQLKYN 231 NK+DL V ES K Y + +AFV + +G ++ S + + Sbjct: 163 AINKMDLNGFDERVFES-IKADYLKFAEGIAFKPTTMAFVPMSALKGDNVVNKSERSPWY 221 Query: 232 IEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVG 291 I++ + + ++ R V VN+P G +A G + KG Sbjct: 222 AGQSLMEILETVEIASDRNYTDLRFPVQY---VNRPNLNFRGFAGTLASGIVHKG----- 273 Query: 292 QEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRAD 351 EI V P GK S++ S+ +L+ A PG + + + + + R D Sbjct: 274 DEIVVLPS-------GK------SSRVKSIVTFEGELEQAGPGQAVTLTMEDEIDISRGD 320 Query: 352 RMV 354 +V Sbjct: 321 LLV 323 >1R5O-A nrPDB Length = 467 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 43/175 (24%), Positives = 75/175 (42%), Gaps = 23/175 (13%) Query: 42 INIGTIGHVAHGKSTV---VKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPR 98 +NI IGHV GKST+ + ++G+ R ++ER + + LD S R Sbjct: 44 VNIVFIGHVDAGKSTLGGNILFLTGMVDKRTMEKIEREAKEAGKESWYLSWALDSTSEER 103 Query: 99 PECYRSCGSSTPDEFPTDIPGTKGNFKLV-RHVSFVDCPGHDILMATMLNGAAVMDAALL 157 E + + F+ R S +D PGH + M+NGA+ D +L Sbjct: 104 -------------EKGKTVEVGRAYFETEHRRFSLLDAPGHKGYVTNMINGASQADIGVL 150 Query: 158 LIAGNESCPQP------QTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQ 206 +I+ + QT EH + H++++ NK+D ++E+Y++ Sbjct: 151 VISARRGEFEAGFERGGQTREHAVLARTQGINHLVVVINKMDEPSVQWSEERYKE 205 >4C0S-A nrPDB Length = 463 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 25/110 (22%), Positives = 53/110 (48%), Gaps = 12/110 (10%) Query: 129 HVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNES------CPQPQTSEHLAAIEIMKL 182 +++ +D PGH + M+ G + D A+L++A QT EH + + Sbjct: 86 YITIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGV 145 Query: 183 KHILILQNKIDLVKESQAKEQYEQILAFVQGTVAE------GAPIIPISA 226 K +++ NK+D + + ++++Y++I+ V + + P +PIS Sbjct: 146 KQLIVGVNKMDSTEPAYSEKRYDEIVKEVSAYIKKIGYNPATVPFVPISG 195 >2YWH-A nrPDB Length = 600 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 73/269 (27%), Positives = 105/269 (39%), Gaps = 68/269 (25%) Query: 43 NIGTIGHVAHGKSTVVKAI---SGVHTVRFKN---------ELERNITIKLGYANAKIYK 90 N I HV HGKST+ + +G + R K E ER IT+K+ A YK Sbjct: 8 NFCIIAHVDHGKSTLADRLLEYTGAISEREKREQLLDTLDVERERGITVKMQ-AVRMFYK 66 Query: 91 LDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGN-FKLVRHVSFVDCPGHDILMATMLNGA 149 D GN +KL +D PGH + Sbjct: 67 AKD----------------------------GNTYKL----HLIDTPGHVDFSYEVSRAL 94 Query: 150 AVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQ--NKIDL--VKESQAKEQYE 205 A + ALLLI ++ + A+E + ++I+ NKIDL + K+Q E Sbjct: 95 AACEGALLLIDASQGIEAQTVANFWKAVE----QDLVIIPVINKIDLPSADVDRVKKQIE 150 Query: 206 QILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVN 265 ++L G E A I SA+ IE + E IV +IP P D + ++ S+ Sbjct: 151 EVL----GLDPEEA--ILASAKEGIGIEEILEAIVNRIPPPKGDPQKPLKALIFDSY--- 201 Query: 266 KPGCEVDDLKGGVAGGSILKGVLKVGQEI 294 D +G VA I G +K G +I Sbjct: 202 -----YDPYRGAVAFVRIFDGEVKPGDKI 225 >5LZS-jj nrPDB Length = 462 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 22/86 (25%), Positives = 44/86 (51%), Gaps = 6/86 (6%) Query: 129 HVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNES------CPQPQTSEHLAAIEIMKL 182 +V+ +D PGH + M+ G + D A+L++A QT EH + + Sbjct: 86 YVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGV 145 Query: 183 KHILILQNKIDLVKESQAKEQYEQIL 208 K +++ NK+D + ++++YE+I+ Sbjct: 146 KQLIVGVNKMDSTEPPYSQKRYEEIV 171 >4V6V-A1 nrPDB Length = 639 Score = 41.6 bits (96), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 23/64 (35%), Positives = 37/64 (57%), Gaps = 2/64 (3%) Query: 130 VSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQ 189 V+ +D PGH +A + +V+D A+LL++ + Q QT A++IMK+ I + Sbjct: 70 VNIIDTPGHMDFLAEVYRSLSVLDGAVLLVSAKDGI-QAQTRILFHALQIMKIPTIFFI- 127 Query: 190 NKID 193 NKID Sbjct: 128 NKID 131 >3MCA-A nrPDB Length = 592 Score = 41.2 bits (95), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 27/106 (25%), Positives = 52/106 (49%), Gaps = 15/106 (14%) Query: 134 DCPGHDILMATMLNGAAVMDAALLLIAGNES------CPQPQTSEHLAAIEIMKLKHILI 187 D PGH ++ M+ GA+ D A+L++ +++ QT EH + + + I++ Sbjct: 261 DAPGHRDFISGMIAGASSADFAVLVVDSSQNNFERGFLENGQTREHAYLLRALGISEIVV 320 Query: 188 LQNKIDLVKESQAKEQYEQILAFVQ-------GTVAEGAPIIPISA 226 NK+DL+ S +++++++I V G +PISA Sbjct: 321 SVNKLDLM--SWSEDRFQEIKNIVSDFLIKMVGFKTSNVHFVPISA 364 >5FG3-A nrPDB Length = 623 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 24/66 (36%), Positives = 38/66 (57%), Gaps = 6/66 (9%) Query: 132 FVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHI--LILQ 189 F+D PGH++ G +V D A+L++ E +PQT E A+E++K + + LI Sbjct: 85 FIDTPGHELFSNLRRRGGSVADFAILVVDIMEGF-KPQTYE---ALELLKERRVPFLIAA 140 Query: 190 NKIDLV 195 NKID + Sbjct: 141 NKIDRI 146 >1G7S-A nrPDB Length = 594 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 40/164 (24%), Positives = 62/164 (37%), Gaps = 48/164 (29%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYR 103 + +GHV HGK+T++ I G R Sbjct: 8 VSVLGHVDHGKTTLLDHIRGSAV----------------------------------ASR 33 Query: 104 SCGSST----PDEFPTD-IPGTKGNF-------KLVRHVSFVDCPGHDILMATMLNGAAV 151 G T E P D I G G+F + + + F+D PGH+ G A+ Sbjct: 34 EAGGITQHIGATEIPMDVIEGICGDFLKKFSIRETLPGLFFIDTPGHEAFTTLRKRGGAL 93 Query: 152 MDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLV 195 D A+L++ NE +PQT E L + + + + + NKID + Sbjct: 94 ADLAILIVDINEGF-KPQTQEALNILRMYRTPFV-VAANKIDRI 135 >5YT0-A nrPDB Length = 364 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 24/66 (36%), Positives = 38/66 (57%), Gaps = 6/66 (9%) Query: 132 FVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHI--LILQ 189 F+D PGH++ G +V D A+L++ E +PQT E A+E++K + + LI Sbjct: 85 FIDTPGHELFSNLRRRGGSVADFAILVVDIMEGF-KPQTYE---ALELLKERRVPFLIAA 140 Query: 190 NKIDLV 195 NKID + Sbjct: 141 NKIDRI 146 >5LZY-jj nrPDB Length = 710 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 46/179 (25%), Positives = 75/179 (41%), Gaps = 31/179 (17%) Query: 42 INIGTIGHVAHGKSTVVKAISGV-----HTVRFKNELERNITIKLGYANAKIYKLDDPSC 96 +N+ IGHV GKST++ + + K E E K +A A + LD+ Sbjct: 287 LNLVVIGHVDAGKSTLMGHMLYLLGNINKRTMHKYEQESKKAGKASFAYAWV--LDETGE 344 Query: 97 PRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAAL 156 R T E T + ++ +D PGH + M+ GAA D A+ Sbjct: 345 ERERGVTMDVGMTKFETTTKV------------ITLMDAPGHKDFIPNMITGAAQADVAV 392 Query: 157 LLI--------AGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQI 207 L++ AG E+ QT EH + + + + + NK+D V Q E++++I Sbjct: 393 LVVDASRGEFEAGFETG--GQTREHGLLVRSLGVTQLAVAVNKMDQVNWQQ--ERFQEI 447 >2P8Y-T nrPDB Length = 842 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 52/184 (28%), Positives = 80/184 (43%), Gaps = 42/184 (22%) Query: 43 NIGTIGHVAHGKSTVVKAI---SGVHT------VRF----KNELERNITIKLGYANAKIY 89 N+ I HV HGKST+ ++ +G+ + RF K+E ER ITIK Sbjct: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIK--------- 71 Query: 90 KLDDPSCPRPECYRSCGSSTPDEFPTDIP-GTKGNFKLVRHVSFVDCPGHDILMATMLNG 148 S S DE +I T GN L ++ +D PGH + + Sbjct: 72 ----------STAISLYSEMSDEDVKEIKQKTDGNSFL---INLIDSPGHVDFSSEVTAA 118 Query: 149 AAVMDAALLLIAGNES-CPQPQTSEHLAAIEIMKLKHILILQNKID--LVKESQAKEQYE 205 V D AL+++ E C Q +T A E ++K ++++ NK+D L++ +KE Sbjct: 119 LRVTDGALVVVDTIEGVCVQTETVLRQALGE--RIKPVVVI-NKVDRALLELQVSKEDLY 175 Query: 206 QILA 209 Q A Sbjct: 176 QTFA 179 >5KCS-1w nrPDB Length = 639 Score = 36.6 bits (83), Expect = 0.023, Method: Compositional matrix adjust. Identities = 22/64 (34%), Positives = 34/64 (53%), Gaps = 2/64 (3%) Query: 130 VSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQ 189 V+ +D PGH +A + +V+D A+LLI+ + Q QT A+ M + I + Sbjct: 70 VNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGV-QAQTRILFHALRKMGIPTIFFI- 127 Query: 190 NKID 193 NKID Sbjct: 128 NKID 131 >3P27-A nrPDB Length = 483 Score = 36.6 bits (83), Expect = 0.027, Method: Compositional matrix adjust. Identities = 30/125 (24%), Positives = 55/125 (44%), Gaps = 19/125 (15%) Query: 129 HVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQP------QTSEHLAAIEIMKL 182 + + VD PGH + + G + D A+L + + + + QT EH+ + + Sbjct: 112 NFTIVDAPGHRDFVPNAIMGISQADMAILCVDCSTNAFESGFDLDGQTKEHMLLASSLGI 171 Query: 183 KHILILQNKIDLVKESQAKEQYEQI----------LAFVQGTVAEGAPIIPISAQLKYNI 232 +++I NK+D V SQ +++E+I + F + + PI S + Y I Sbjct: 172 HNLIIAMNKMDNVDWSQ--QRFEEIKSKLLPYLVDIGFFEDNI-NWVPISGFSGEGVYKI 228 Query: 233 EVVCE 237 E E Sbjct: 229 EYTDE 233 >3WNB-A nrPDB Length = 370 Score = 36.2 bits (82), Expect = 0.032, Method: Compositional matrix adjust. Identities = 44/193 (22%), Positives = 79/193 (40%), Gaps = 26/193 (13%) Query: 122 GNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQ---PQTSEHLAAIE 178 N K R++ FVD + + +++ + D A+L I PQ T E + A++ Sbjct: 54 NNDKEGRNMVFVDAHSYPKTLKSLITALNISDIAVLCIP-----PQGLDAHTGECIIALD 108 Query: 179 IMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISA------------ 226 ++ KH +I + D E ++ GTV + I ++ Sbjct: 109 LLGFKHGIIALTRSDSTHMHAIDELKAKLKVITSGTVLQDWECISLNTNKSAKNPFEGVD 168 Query: 227 QLKYNIEVVCEYIVKKIPVPPRDFTSEP-RLIVIRSFDVNKPGCEV-DDLKGGVAGGSIL 284 +LK I V E KI + S P R+ + +F+V GC V +K G++ Sbjct: 169 ELKARINEVAE----KIEAENAELNSLPARIFIDHAFNVTGKGCVVLGVVKQGISKDKDK 224 Query: 285 KGVLKVGQEIEVR 297 + + ++IE+R Sbjct: 225 TKIFPLDRDIEIR 237 >3IZQ-1 nrPDB Length = 611 Score = 36.2 bits (82), Expect = 0.033, Method: Compositional matrix adjust. Identities = 30/125 (24%), Positives = 55/125 (44%), Gaps = 19/125 (15%) Query: 129 HVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQP------QTSEHLAAIEIMKL 182 + + VD PGH + + G + D A+L + + + + QT EH+ + + Sbjct: 246 NFTIVDAPGHRDFVPNAIMGISQADMAILCVDCSTNAFESGFDLDGQTKEHMLLASSLGI 305 Query: 183 KHILILQNKIDLVKESQAKEQYEQI----------LAFVQGTVAEGAPIIPISAQLKYNI 232 +++I NK+D V SQ +++E+I + F + + PI S + Y I Sbjct: 306 HNLIIAMNKMDNVDWSQ--QRFEEIKSKLLPYLVDIGFFEDNI-NWVPISGFSGEGVYKI 362 Query: 233 EVVCE 237 E E Sbjct: 363 EYTDE 367 >2LKD-A nrPDB Length = 178 Score = 34.7 bits (78), Expect = 0.093, Method: Compositional matrix adjust. Identities = 19/66 (28%), Positives = 35/66 (53%), Gaps = 2/66 (3%) Query: 128 RHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILI 187 + ++F+D PGH+ GA V D +L++A ++ PQT E + + + I++ Sbjct: 55 KKITFLDTPGHEAFTTMRARGAQVTDIVILVVAADDGV-MPQTVEAINHAKAANVP-IIV 112 Query: 188 LQNKID 193 NK+D Sbjct: 113 AINKMD 118 >5IMR-C nrPDB Length = 610 Score = 34.3 bits (77), Expect = 0.11, Method: Compositional matrix adjust. Identities = 56/231 (24%), Positives = 84/231 (36%), Gaps = 74/231 (32%) Query: 43 NIGTIGHVAHGKSTVV-KAISGVHTVRFKN-----------ELERNITIKLGYANAKIYK 90 N I HV HGKST+ + + H V + E ER ITIK Sbjct: 11 NFSIIAHVDHGKSTLADRILELTHAVSDREMREQFLDSLELERERGITIKASAVRV---- 66 Query: 91 LDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAA 150 YR+ K + V H+ +D PGH + A Sbjct: 67 ----------TYRA----------------KDGEEYVFHL--IDTPGHVDFTYEVSRALA 98 Query: 151 VMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKH---ILILQNKIDL--VKESQAKEQYE 205 ++ LL++ ++ +E LA M L+H I+ + NKIDL + + + E Sbjct: 99 AVEGVLLVVDASQGV----EAETLAKF-YMALEHGHVIIPVINKIDLPNARPLEVALEVE 153 Query: 206 QILA-------FVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRD 249 ++L F G EG +E + E IV++IP P D Sbjct: 154 EVLGLPADEAIFASGKTGEG-------------VEEILEAIVQRIPPPKGD 191 >5J8B-z nrPDB Length = 679 Score = 34.3 bits (77), Expect = 0.11, Method: Compositional matrix adjust. Identities = 56/231 (24%), Positives = 84/231 (36%), Gaps = 74/231 (32%) Query: 43 NIGTIGHVAHGKSTVV-KAISGVHTVRFKN-----------ELERNITIKLGYANAKIYK 90 N I HV HGKST+ + + H V + E ER ITIK Sbjct: 80 NFSIIAHVDHGKSTLADRILELTHAVSDREMREQFLDSLELERERGITIKASAVRV---- 135 Query: 91 LDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAA 150 YR+ K + V H+ +D PGH + A Sbjct: 136 ----------TYRA----------------KDGEEYVFHL--IDTPGHVDFTYEVSRALA 167 Query: 151 VMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKH---ILILQNKIDL--VKESQAKEQYE 205 ++ LL++ ++ +E LA M L+H I+ + NKIDL + + + E Sbjct: 168 AVEGVLLVVDASQGV----EAETLAKF-YMALEHGHVIIPVINKIDLPNARPLEVALEVE 222 Query: 206 QILA-------FVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRD 249 ++L F G EG +E + E IV++IP P D Sbjct: 223 EVLGLPADEAIFASGKTGEG-------------VEEILEAIVQRIPPPKGD 260 >3CB4-D nrPDB Length = 599 Score = 33.9 bits (76), Expect = 0.18, Method: Compositional matrix adjust. Identities = 62/268 (23%), Positives = 104/268 (38%), Gaps = 62/268 (23%) Query: 43 NIGTIGHVAHGKST----VVKAISGVHTVRFKN--------ELERNITIKLGYANAKIYK 90 N I H+ HGKST +++ G+ + E ER ITIK A+ Sbjct: 6 NFSIIAHIDHGKSTLSDRIIQICGGLSDREMEAQVLDSMDLERERGITIK-----AQSVT 60 Query: 91 LDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAA 150 LD Y++ T ++F+D PGH + A Sbjct: 61 LD---------YKASDGET------------------YQLNFIDTPGHVDFSYEVSRSLA 93 Query: 151 VMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDL--VKESQAKEQYEQIL 208 + ALL++ + + A+E M L+ + +L NKIDL + E+ E I+ Sbjct: 94 ACEGALLVVDAGQGVEAQTLANCYTAME-MDLEVVPVL-NKIDLPAADPERVAEEIEDIV 151 Query: 209 AFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPG 268 + + SA+ ++ V E +V+ IP P D + ++I S+ Sbjct: 152 GI------DATDAVRCSAKTGVGVQDVLERLVRDIPPPEGDPEGPLQALIIDSW------ 199 Query: 269 CEVDDLKGGVAGGSILKGVLKVGQEIEV 296 D+ G V+ I G L+ G +++V Sbjct: 200 --FDNYLGVVSLIRIKNGTLRKGDKVKV 225 >4V6W-Az nrPDB Length = 844 Score = 33.5 bits (75), Expect = 0.23, Method: Compositional matrix adjust. Identities = 49/188 (26%), Positives = 81/188 (43%), Gaps = 37/188 (19%) Query: 43 NIGTIGHVAHGKSTVVKA-------ISGVHT--VRF----KNELERNITIKLGYANAKIY 89 N+ I HV HGKST+ + I+G RF K+E ER ITIK A + + Sbjct: 21 NMSVIAHVDHGKSTLTDSLVSKAGIIAGAKAGETRFTDTRKDEQERCITIK-STAISMYF 79 Query: 90 KLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGA 149 ++++ + PD+ + G ++ +D PGH + + Sbjct: 80 EVEEKDL--------VFITHPDQREKECKGF--------LINLIDSPGHVDFSSEVTAAL 123 Query: 150 AVMDAALLLI-AGNESCPQPQTSEHLAAIEIMKLKHILILQNKID---LVKESQAKEQYE 205 V D AL+++ + C Q +T A E ++K IL + NK+D L + A+E Y+ Sbjct: 124 RVTDGALVVVDCVSGVCVQTETVLRQAIAE--RIKPILFM-NKMDRALLELQLDAEELYQ 180 Query: 206 QILAFVQG 213 V+ Sbjct: 181 TFQRIVEN 188 >6GB2-BC nrPDB Length = 657 Score = 33.1 bits (74), Expect = 0.24, Method: Compositional matrix adjust. Identities = 30/113 (26%), Positives = 56/113 (49%), Gaps = 5/113 (4%) Query: 130 VSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQ 189 ++F+D PGH A GA V D +L++A ++ + QT E + + ++ IL + Sbjct: 160 ITFLDTPGHAAFSAMRARGAQVTDIVVLVVAADDGVMK-QTVESIQHAKDAQVPIILAV- 217 Query: 190 NKIDLVKESQAKEQYEQILAFVQGTVAEGAPI--IPISAQLKYNIEVVCEYIV 240 NK D E+ ++ +++LA+ G + +P+SA N+ + E V Sbjct: 218 NKCDKA-EADPEKVKKELLAYDVVCEDYGGDVQAVPVSALTGDNLMALAEATV 269 >4CRN-P nrPDB Length = 430 Score = 33.1 bits (74), Expect = 0.26, Method: Compositional matrix adjust. Identities = 23/90 (25%), Positives = 48/90 (53%), Gaps = 6/90 (6%) Query: 128 RHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQP------QTSEHLAAIEIMK 181 R + +D PGH + ++ M+ GA+ D +L+I+ + + QT EH + Sbjct: 83 RRYTILDAPGHKMYVSEMIGGASQADVGVLVISARKGEYETGFERGGQTREHALLAKTQG 142 Query: 182 LKHILILQNKIDLVKESQAKEQYEQILAFV 211 + ++++ NK+D + +KE+Y+Q ++ V Sbjct: 143 VNKMVVVVNKMDDPTVNWSKERYDQCVSNV 172 >3JCN-b nrPDB Length = 890 Score = 31.6 bits (70), Expect = 0.72, Method: Compositional matrix adjust. Identities = 14/45 (31%), Positives = 24/45 (53%), Gaps = 1/45 (2%) Query: 130 VSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHL 174 ++F+D PGH + GA D +L++A ++ PQT E + Sbjct: 440 ITFLDTPGHAAFTSMRARGAQATDIVVLVVAADDGV-MPQTIEAI 483 >1ZO1-I nrPDB Length = 501 Score = 31.6 bits (70), Expect = 0.75, Method: Compositional matrix adjust. Identities = 14/45 (31%), Positives = 24/45 (53%), Gaps = 1/45 (2%) Query: 130 VSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHL 174 ++F+D PGH + GA D +L++A ++ PQT E + Sbjct: 53 ITFLDTPGHAAFTSMRARGAQATDIVVLVVAADDGV-MPQTIEAI 96 >1MKY-A nrPDB Length = 439 Score = 31.2 bits (69), Expect = 0.91, Method: Compositional matrix adjust. Identities = 35/137 (25%), Positives = 59/137 (43%), Gaps = 14/137 (10%) Query: 124 FKLVRHVSFVDCPGHDILMATM----LNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEI 179 FKLV D P DI+ M LN D L ++ G + E LA Sbjct: 51 FKLVDTCGVFDNP-QDIISQKMKEVTLNMIREADLVLFVVDGKRGITK--EDESLADFLR 107 Query: 180 MKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYI 239 +++ NK + ++E + + + E ++ G PI P+SA+ N++ + E I Sbjct: 108 KSTVDTILVANKAENLREFEREVKPELY------SLGFGEPI-PVSAEHNINLDTMLETI 160 Query: 240 VKKIPVPPRDFTSEPRL 256 +KK+ D S+P + Sbjct: 161 IKKLEEKGLDLESKPEI 177 >3IZY-P nrPDB Length = 537 Score = 31.2 bits (69), Expect = 1.0, Method: Compositional matrix adjust. Identities = 24/83 (28%), Positives = 44/83 (53%), Gaps = 7/83 (8%) Query: 130 VSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKH--ILI 187 ++F+D PGH A G V D +L++A ++ + QT E +I+ K H I++ Sbjct: 54 ITFLDTPGHAAFSAMRARGTQVTDIVILVVAADDGVMK-QTVE---SIQHAKDAHVPIVL 109 Query: 188 LQNKIDLVKESQAKEQYEQILAF 210 NK D E+ ++ +++LA+ Sbjct: 110 AINKCDKA-EADPEKVKKELLAY 131 >2R00-A nrPDB Length = 336 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 26/88 (29%), Positives = 41/88 (46%), Gaps = 13/88 (14%) Query: 357 VLGAVGA----LPEIFTELEISYFLLRRLLGVRTEG-----DKKAAKVQKLSKNEVLMVN 407 + GA GA + E+ E E L L R+EG + K +VQ + + + V+ Sbjct: 8 IFGATGAVGETMLEVLQEREFPVDELFLLASERSEGKTYRFNGKTVRVQNVEEFDWSQVH 67 Query: 408 IGSLSTGGRVSA----VKADLGKIVLTN 431 I S GG +SA + A+ G +V+ N Sbjct: 68 IALFSAGGELSAKWAPIAAEAGVVVIDN 95 >3I8B-A nrPDB Length = 515 Score = 29.6 bits (65), Expect = 2.7, Method: Compositional matrix adjust. Identities = 13/32 (40%), Positives = 20/32 (62%), Gaps = 1/32 (3%) Query: 124 FKLVRHVS-FVDCPGHDILMATMLNGAAVMDA 154 + L VS F DC GH + +A +NG+ ++DA Sbjct: 308 YDLTGAVSGFADCTGHYLPLACTINGSRILDA 339 >3K53-A nrPDB Length = 271 Score = 29.3 bits (64), Expect = 3.9, Method: Compositional matrix adjust. Identities = 23/76 (30%), Positives = 41/76 (53%), Gaps = 13/76 (17%) Query: 180 MKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISA-------QLKYNI 232 M++K+I+++ NK DL+K+ AK +++ + G P+IP +A +LK I Sbjct: 107 MEVKNIILVLNKFDLLKKKGAKIDIKKMRKEL------GVPVIPTNAKKGEGVEELKRMI 160 Query: 233 EVVCEYIVKKIPVPPR 248 ++ E V P+ PR Sbjct: 161 ALMAEGKVTTNPIIPR 176 >6AK1-A nrPDB Length = 488 Score = 28.9 bits (63), Expect = 4.8, Method: Compositional matrix adjust. Identities = 18/53 (33%), Positives = 27/53 (50%), Gaps = 3/53 (5%) Query: 3 GGEAGVTLGQPHLSRQDLTTLDVTKLTPLSHEVIS---RQATINIGTIGHVAH 52 G A +T QP+L + L+TLD ++ V+S A +NIG +AH Sbjct: 102 GVTAAITFEQPYLLARRLSTLDHLTKGRVAWNVVSSYLNSAALNIGMDQQLAH 154 >4A9A-A nrPDB Length = 376 Score = 28.5 bits (62), Expect = 5.8, Method: Compositional matrix adjust. Identities = 17/61 (27%), Positives = 32/61 (52%), Gaps = 2/61 (3%) Query: 36 ISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIK--LGYANAKIYKLDD 93 ++R ++G +G + GKST++ ++G + + E +T+ + Y AKI LD Sbjct: 67 VARTGVASVGFVGFPSVGKSTLLSKLTGTESEAAEYEFTTLVTVPGVIRYKGAKIQMLDL 126 Query: 94 P 94 P Sbjct: 127 P 127 >1QVJ-A nrPDB Length = 292 Score = 28.5 bits (62), Expect = 6.6, Method: Compositional matrix adjust. Identities = 17/50 (34%), Positives = 26/50 (52%), Gaps = 3/50 (6%) Query: 303 KDSEGKLMCKPIFSKIVSLFA--EHNDL-QYAAPGGLIGVGTKIDPTLCR 349 +DS G + P+ K + F + D ++A PGG++ G KI TL R Sbjct: 122 RDSSGNKIMHPVSGKHILQFVAIKRKDCGEWAIPGGMVDPGEKISATLKR 171 >3HPD-A nrPDB Length = 265 Score = 28.1 bits (61), Expect = 7.6, Method: Compositional matrix adjust. Identities = 15/37 (40%), Positives = 25/37 (67%), Gaps = 5/37 (13%) Query: 402 EVLMVNIGSLSTGGRVSAVKA-----DLGKIVLTNPV 433 + +++NIG+L +G R S VKA +LGK ++ +PV Sbjct: 58 DAVVINIGTLDSGWRRSMVKATEIANELGKPIVLDPV 94 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6O81-S nrPDB 640 0.0 6FEC-S nrPDB 554 e-158 3J81-k nrPDB 535 e-152 2D74-A nrPDB 461 e-130 1S0U-A nrPDB 450 e-127 3PEN-A nrPDB 413 e-116 4V5G-AZ nrPDB 301 3e-82 4ZV4-A nrPDB 298 4e-81 5W75-A nrPDB 291 4e-79 3WXM-A nrPDB 291 6e-79 3MMP-A nrPDB 287 9e-78 4J0Q-A nrPDB 278 3e-75 5W76-A nrPDB 278 4e-75 1D2E-A nrPDB 275 3e-74 5LZD-z nrPDB 274 8e-74 1JNY-A nrPDB 272 2e-73 1MJ1-A nrPDB 270 1e-72 6MIJ-A nrPDB 269 3e-72 5W7Q-A nrPDB 268 4e-72 1EFM-A nrPDB 265 2e-71 3WY9-A nrPDB 259 2e-69 5IZL-A nrPDB 238 5e-63 2HDN-B nrPDB 226 1e-59 4C0S-A nrPDB 220 9e-58 5LZS-jj nrPDB 218 4e-57 2B7C-A nrPDB 216 2e-56 4ZU9-A nrPDB 208 3e-54 4D61-i nrPDB 207 1e-53 5LZT-jj nrPDB 207 1e-53 4AC9-A nrPDB 201 6e-52 1ZUN-B nrPDB 189 3e-48 1R5O-A nrPDB 187 8e-48 2YWH-A nrPDB 166 2e-41 3MCA-A nrPDB 155 3e-38 3J4J-A nrPDB 151 8e-37 4KJZ-A nrPDB 150 1e-36 4B44-A nrPDB 148 4e-36 1G7S-A nrPDB 113 3e-25 5FG3-A nrPDB 108 4e-24 5YT0-A nrPDB 104 6e-23 4V6V-A1 nrPDB 103 1e-22 Sequences not found previously or not previously below threshold: 5LZY-jj nrPDB 170 8e-43 4CRN-P nrPDB 147 1e-35 3IZQ-1 nrPDB 146 2e-35 3P27-A nrPDB 145 4e-35 5IMR-C nrPDB 136 2e-32 5J8B-z nrPDB 136 2e-32 3CB4-D nrPDB 122 4e-28 5I4Q-C nrPDB 119 3e-27 5A9Z-CA nrPDB 114 6e-26 6GB2-BC nrPDB 107 1e-23 2LKD-A nrPDB 105 5e-23 5KCS-1w nrPDB 104 9e-23 3IZY-P nrPDB 99 2e-21 4NCL-A nrPDB 100 3e-21 4N3G-A nrPDB 98 7e-21 1ZO1-I nrPDB 95 8e-20 4TN1-B nrPDB 94 1e-19 3JCN-b nrPDB 93 2e-19 4UJC-AB nrPDB 91 1e-18 4NCF-A nrPDB 89 3e-18 3WNB-A nrPDB 89 4e-18 4V8Y-CP nrPDB 88 6e-18 3WBI-A nrPDB 88 9e-18 4V8Z-CV nrPDB 86 3e-17 5TY0-A nrPDB 83 2e-16 5VH6-A nrPDB 82 6e-16 3ZZ0-A nrPDB 81 7e-16 4V6W-Az nrPDB 81 8e-16 6BK7-A nrPDB 80 2e-15 6N0I-A nrPDB 78 7e-15 5H7J-A nrPDB 77 2e-14 5H7K-A nrPDB 77 2e-14 2P8Y-T nrPDB 76 4e-14 4FN5-A nrPDB 75 9e-14 5TV2-A nrPDB 74 2e-13 4V7D-BZ nrPDB 73 3e-13 6B8D-A nrPDB 73 3e-13 4WQY-BZ nrPDB 73 4e-13 6MTD-v nrPDB 72 5e-13 6NOT-A nrPDB 71 1e-12 3TR5-A nrPDB 70 3e-12 3VQT-A nrPDB 68 1e-11 4V89-AW nrPDB 66 2e-11 3JB9-B nrPDB 65 8e-11 1WDT-A nrPDB 63 2e-10 6ID0-C nrPDB 61 9e-10 5G06-P nrPDB 60 2e-09 4ZKD-A nrPDB 60 2e-09 3R9W-A nrPDB 58 6e-09 5KH0-A nrPDB 55 1e-07 1MKY-A nrPDB 52 6e-07 1U0L-A nrPDB 48 6e-06 3K53-A nrPDB 47 2e-05 5HXB-X nrPDB 46 4e-05 1YVD-A nrPDB 46 4e-05 2QTH-A nrPDB 44 9e-05 2CXX-A nrPDB 44 1e-04 2E87-A nrPDB 44 2e-04 2F7S-A nrPDB 43 2e-04 2WJG-A nrPDB 42 5e-04 5LAD-A nrPDB 42 6e-04 1EK0-A nrPDB 41 8e-04 2IEZ-A nrPDB 41 8e-04 2IEY-A nrPDB 41 8e-04 3IEU-A nrPDB 41 0.001 2WJI-A nrPDB 41 0.002 1LNZ-A nrPDB 40 0.002 1XZP-A nrPDB 40 0.003 2FG5-A nrPDB 39 0.003 3J8G-X nrPDB 39 0.005 3H2Y-A nrPDB 38 0.011 2UVF-A nrPDB 38 0.012 2WIC-A nrPDB 38 0.012 3CLV-A nrPDB 37 0.014 4HI0-E nrPDB 37 0.014 3GEH-A nrPDB 37 0.015 4DCU-A nrPDB 37 0.016 2QU8-A nrPDB 37 0.022 5DN8-A nrPDB 36 0.033 2KE5-A nrPDB 36 0.038 1UDX-A nrPDB 36 0.047 1WF3-A nrPDB 35 0.061 2QPT-A nrPDB 35 0.081 3A1U-A nrPDB 35 0.083 2X77-A nrPDB 34 0.091 3A1W-A nrPDB 34 0.10 5CM8-B nrPDB 34 0.11 4R98-A nrPDB 34 0.16 3IBY-A nrPDB 34 0.17 1YR7-A nrPDB 33 0.26 5ZZM-A nrPDB 33 0.28 2HF8-A nrPDB 33 0.31 2YV5-A nrPDB 33 0.43 5UHV-A nrPDB 32 0.63 3CON-A nrPDB 32 0.63 3ZYS-B nrPDB 32 0.64 5GTM-A nrPDB 32 0.71 2GAO-A nrPDB 31 0.95 4CSU-9 nrPDB 31 0.97 1F6B-A nrPDB 31 0.98 4V7F-o nrPDB 31 1.1 3LRP-A nrPDB 31 1.1 4MKI-B nrPDB 31 1.2 4HZU-A nrPDB 31 1.4 2DYK-A nrPDB 31 1.5 4LR2-A nrPDB 31 1.6 5M04-A nrPDB 31 1.6 6OIJ-A nrPDB 31 1.7 6FNP-B nrPDB 30 2.6 2YKR-W nrPDB 30 2.8 5NO4-Z nrPDB 30 2.8 3D3R-A nrPDB 29 3.1 4CPD-A nrPDB 29 3.2 4WA7-A nrPDB 29 3.3 4P4S-B nrPDB 29 3.4 2BCJ-Q nrPDB 29 3.5 6FT6-s nrPDB 29 3.5 3NXS-A nrPDB 29 3.9 4P4S-A nrPDB 29 4.0 5XNM-B nrPDB 29 4.7 3TK1-A nrPDB 29 4.9 1VIA-A nrPDB 29 4.9 6HA8-V nrPDB 28 7.8 5NKM-B nrPDB 28 8.0 3MD0-A nrPDB 28 8.6 >6O81-S nrPDB Length = 472 Score = 640 bits (1650), Expect = 0.0, Method: Composition-based stats. Identities = 470/472 (99%), Positives = 470/472 (99%) Query: 1 MAGGEAGVTLGQPHLSRQDLTTLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKA 60 MAGGEAGVTLGQPHLSRQDLTTLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKA Sbjct: 1 MAGGEAGVTLGQPHLSRQDLTTLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKA 60 Query: 61 ISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGT 120 ISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGT Sbjct: 61 ISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGT 120 Query: 121 KGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIM 180 KGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIM Sbjct: 121 KGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIM 180 Query: 181 KLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIV 240 KLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIV Sbjct: 181 KLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIV 240 Query: 241 KKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGI 300 KKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGI Sbjct: 241 KKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGI 300 Query: 301 VSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGA 360 VSK SEGKLMCKP FSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGA Sbjct: 301 VSKASEGKLMCKPKFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGA 360 Query: 361 VGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAV 420 VGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAV Sbjct: 361 VGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAV 420 Query: 421 KADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQIRRGVTIKPTVDDD 472 KADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQIRRGVTIKPTVDDD Sbjct: 421 KADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQIRRGVTIKPTVDDD 472 >6FEC-S nrPDB Length = 422 Score = 554 bits (1427), Expect = e-158, Method: Composition-based stats. Identities = 422/422 (100%), Positives = 422/422 (100%) Query: 39 QATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPR 98 QATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPR Sbjct: 1 QATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPR 60 Query: 99 PECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLL 158 PECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLL Sbjct: 61 PECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLL 120 Query: 159 IAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEG 218 IAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEG Sbjct: 121 IAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEG 180 Query: 219 APIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGV 278 APIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGV Sbjct: 181 APIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGV 240 Query: 279 AGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIG 338 AGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIG Sbjct: 241 AGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIG 300 Query: 339 VGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKL 398 VGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKL Sbjct: 301 VGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKL 360 Query: 399 SKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQ 458 SKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQ Sbjct: 361 SKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQ 420 Query: 459 IR 460 IR Sbjct: 421 IR 422 >3J81-k nrPDB Length = 527 Score = 535 bits (1377), Expect = e-152, Method: Composition-based stats. Identities = 328/444 (73%), Positives = 383/444 (86%), Gaps = 1/444 (0%) Query: 24 DVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGY 83 D +KL PLS E+I+RQATINIGTIGHVAHGKSTVV+AISGV TVRFK+ELERNITIKLGY Sbjct: 83 DFSKLNPLSAEIINRQATINIGTIGHVAHGKSTVVRAISGVQTVRFKDELERNITIKLGY 142 Query: 84 ANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMA 143 ANAKIYK +P+CP P+CYRS S PG G +KLVRHVSFVDCPGHDILM+ Sbjct: 143 ANAKIYKCQEPTCPEPDCYRSFKSDKEISPKCQRPGCPGRYKLVRHVSFVDCPGHDILMS 202 Query: 144 TMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQ 203 TML+GAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKH++ILQNK+DL++E A E Sbjct: 203 TMLSGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHVIILQNKVDLMREESALEH 262 Query: 204 YEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFD 263 + IL F++GT+A+GAPI+PISAQLKYNI+ V E+IVK IPVPPRDF PRLIVIRSFD Sbjct: 263 QKSILKFIRGTIADGAPIVPISAQLKYNIDAVNEFIVKTIPVPPRDFMISPRLIVIRSFD 322 Query: 264 VNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFA 323 VNKPG E++DLKGGVAGGSIL GV K+G EIE+RPGIV+KD +GK+ CKPIFS IVSLFA Sbjct: 323 VNKPGAEIEDLKGGVAGGSILNGVFKLGDEIEIRPGIVTKDDKGKIQCKPIFSNIVSLFA 382 Query: 324 EHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLG 383 E NDL++A PGGLIGVGTK+DPTLCRADR+VGQV+GA G LP I+T++EI+YFLLRRLLG Sbjct: 383 EQNDLKFAVPGGLIGVGTKVDPTLCRADRLVGQVVGAKGHLPNIYTDIEINYFLLRRLLG 442 Query: 384 VRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIAL 443 V+T+G K+ AKV+KL NEVLMVNIGS +TG RV AVKAD+ ++ LT+P CTE+ EKIAL Sbjct: 443 VKTDGQKQ-AKVRKLEPNEVLMVNIGSTATGARVVAVKADMARLQLTSPACTEINEKIAL 501 Query: 444 SRRVEKHWRLIGWGQIRRGVTIKP 467 SRR+EKHWRLIGW I++G T++P Sbjct: 502 SRRIEKHWRLIGWATIKKGTTLEP 525 >2D74-A nrPDB Length = 419 Score = 461 bits (1186), Expect = e-130, Method: Composition-based stats. Identities = 194/431 (45%), Positives = 277/431 (64%), Gaps = 20/431 (4%) Query: 31 LSHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYK 90 + + +RQA +NIG +GHV HGK+T+ KA++GV T EL R ITIK+G+A+A+I Sbjct: 1 MGEKRKTRQAEVNIGMVGHVDHGKTTLTKALTGVWTDTHSEELRRGITIKIGFADAEI-- 58 Query: 91 LDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAA 150 R C + P + +R VSF+D PGH+ LM TML GA+ Sbjct: 59 ------------RRCSNCGRYSTSPICPYCGHETEFIRRVSFIDSPGHEALMTTMLAGAS 106 Query: 151 VMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAF 210 +MD A+L+IA NE CP+PQT EHL A++I+ K+I+I QNKI+LV + +A E Y QI F Sbjct: 107 LMDGAILVIAANEPCPRPQTREHLMALQIIGQKNIIIAQNKIELVDKEKALENYRQIKEF 166 Query: 211 VQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCE 270 ++GTVAE APIIPISA NI+V+ + I + IP P RD P+++V+RSFDVNKPG Sbjct: 167 IKGTVAENAPIIPISALHGANIDVLVKAIEEFIPTPKRDSNKPPKMLVLRSFDVNKPGTP 226 Query: 271 VDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQY 330 + L GGV GSI++G LKVG EIE+RPG+ + G++ +PI ++IVSL A ++ Sbjct: 227 PEKLVGGVLDGSIVQGKLKVGDEIEIRPGV-PYEEHGRIKYEPITTEIVSLQAGGQFVEE 285 Query: 331 AAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDK 390 A PGGL+G+GTK+DP L + D M G V+G G LP ++T+L + LL R++G E Sbjct: 286 AYPGGLVGIGTKLDPYLTKGDLMAGNVVGKPGKLPPVWTDLRLEVHLLERVVGTEQE--- 342 Query: 391 KAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKH 450 V+ + + EVL++N+G+ T G V+A+ D ++ L PVC E GE++A+SR++ Sbjct: 343 --LNVEPIKRKEVLLLNVGTARTMGLVTALGKDEIELKLQIPVCAEPGERVAISRQIGSR 400 Query: 451 WRLIGWGQIRR 461 WRLIG+G I+ Sbjct: 401 WRLIGYGIIKE 411 >1S0U-A nrPDB Length = 408 Score = 450 bits (1158), Expect = e-127, Method: Composition-based stats. Identities = 207/425 (48%), Positives = 279/425 (65%), Gaps = 20/425 (4%) Query: 36 ISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPS 95 + QA +NIG +GHV HGK+++ KA++GV T R EL R I+I+LGYA+ +I Sbjct: 3 LGSQAEVNIGMVGHVDHGKTSLTKALTGVWTDRHSEELRRGISIRLGYADCEI------- 55 Query: 96 CPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAA 155 R C P + +R VSFVD PGH+ LMATML+GA++MD A Sbjct: 56 -------RKCPQCGTYTTKPRCPNCLAETEFLRRVSFVDSPGHETLMATMLSGASLMDGA 108 Query: 156 LLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTV 215 +L+IA NE CPQPQT EHL A+EI+ + I+I+QNKIDLV E QA+E YEQI FV+GT+ Sbjct: 109 ILVIAANEPCPQPQTKEHLMALEILGIDKIIIVQNKIDLVDEKQAEENYEQIKEFVKGTI 168 Query: 216 AEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLK 275 AE APIIPISA + NI+V+ + I IP P RD + PR+ V RSFD+NKPG E+ DLK Sbjct: 169 AENAPIIPISAHHEANIDVLLKAIQDFIPTPKRDPDATPRMYVARSFDINKPGTEIKDLK 228 Query: 276 GGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGG 335 GGV GG+I++GV KVG EIE+RPGI + K KP+ +KIVSL A + L+ A PGG Sbjct: 229 GGVLGGAIIQGVFKVGDEIEIRPGIKVTEGN-KTFWKPLTTKIVSLAAGNTILRKAHPGG 287 Query: 336 LIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKV 395 LIGVGT +DP L ++D + G V+G G LP I ++ I LL R++G + E K+ Sbjct: 288 LIGVGTTLDPYLTKSDALTGSVVGLPGTLPPIREKITIRANLLDRVVGTKEE-----LKI 342 Query: 396 QKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIG 455 + L EVLM+NIG+ +T G +++ + D+ I L P+C E+G+++A+SRRV WRLIG Sbjct: 343 EPLRTGEVLMLNIGTATTAGVITSARGDIADIKLKLPICAEIGDRVAISRRVGSRWRLIG 402 Query: 456 WGQIR 460 +G I Sbjct: 403 YGTIE 407 >3PEN-A nrPDB Length = 403 Score = 413 bits (1061), Expect = e-116, Method: Composition-based stats. Identities = 177/423 (41%), Positives = 263/423 (62%), Gaps = 27/423 (6%) Query: 39 QATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPR 98 Q +NIG +GHV HGK+T+V+AI+G+ T + KLGYA I + SC + Sbjct: 6 QPEVNIGVVGHVDHGKTTLVQAITGIWTSK-----------KLGYAETNIGVCE--SCKK 52 Query: 99 PECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLL 158 PE Y E G+ K +R +SF+D PGH++LMATML+GAA+MD A+L+ Sbjct: 53 PEAY-------VTEPSCKSCGSDDEPKFLRRISFIDAPGHEVLMATMLSGAALMDGAILV 105 Query: 159 IAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEG 218 +A NE PQPQT EH A+ I+ +K+++I+QNK+D+V + +A QY QI F +GT AE Sbjct: 106 VAANEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSKEEALSQYRQIKQFTKGTWAEN 165 Query: 219 APIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGV 278 PIIP+SA K NI+ + E I + I P RD + +P ++VIRSFDVNKPG + ++LKGGV Sbjct: 166 VPIIPVSALHKINIDSLIEGIEEYIKTPYRDLSQKPVMLVIRSFDVNKPGTQFNELKGGV 225 Query: 279 AGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIG 338 GGSI++G+ KV QEI+V PG+ + +GK+ +PIF+KI S+ + + A PGGL+ Sbjct: 226 IGGSIIQGLFKVDQEIKVLPGL-RVEKQGKVSYEPIFTKISSIRFGDEEFKEAKPGGLVA 284 Query: 339 VGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKL 398 +GT +DP+L +AD ++G ++ A + + I Y LL R++G K+ KV + Sbjct: 285 IGTYLDPSLTKADNLLGSIITLADAEVPVLWNIRIKYNLLERVVGA-----KEMLKVDPI 339 Query: 399 SKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGE-KIALSRRVEKHWRLIGWG 457 E LM+++GS +T G V++VK D ++ L PV + +SR++ WR+IGWG Sbjct: 340 RAKETLMLSVGSSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQIAGRWRMIGWG 399 Query: 458 QIR 460 + Sbjct: 400 LVE 402 >4V5G-AZ nrPDB Length = 406 Score = 301 bits (771), Expect = 3e-82, Method: Composition-based stats. Identities = 107/449 (23%), Positives = 174/449 (38%), Gaps = 71/449 (15%) Query: 34 EVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDD 93 E + + +N+GTIGHV HGK+T+ A++ V N K Y D Sbjct: 5 EFVRTKPHVNVGTIGHVDHGKTTLTAALTYVAAAENPN------------VEVKDYGDID 52 Query: 94 PSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMD 153 P ++ E+ T RH S VDCPGH + M+ GAA MD Sbjct: 53 K-APEERARGITINTAHVEYET----------AKRHYSHVDCPGHADYIKNMITGAAQMD 101 Query: 154 AALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQG 213 A+L+++ + P PQT EH+ + + +I++ NK+D+V + + + E + + Sbjct: 102 GAILVVSAADG-PMPQTREHILLARQVGVPYIVVFMNKVDMVDDPELLDLVEMEVRDLLN 160 Query: 214 TV---AEGAPIIPISAQLKY------------------NIEVVCEYIVKKIPVPPRDFTS 252 + P+I SA L I + + I + IP P RD Sbjct: 161 QYEFPGDEVPVIRGSALLALEQMHRNPKTRRGENEWVDKIWELLDAIDEYIPTPVRDVDK 220 Query: 253 EPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCK 312 + V F + +G VA G I +G +KVG E+E+ V E + Sbjct: 221 PFLMPVEDVFTITG--------RGTVATGRIERGKVKVGDEVEI----VGLAPETRRTV- 267 Query: 313 PIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELE 372 + + LQ G +GV + + R + GQVL G++ T+ E Sbjct: 268 -----VTGVEMHRKTLQEGIAGDNVGVLLR---GVSREEVERGQVLAKPGSI-TPHTKFE 318 Query: 373 ISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNP 432 S ++L++ G R G + Q + + + V + L P Sbjct: 319 ASVYVLKKEEGGRHTGFFSGYRPQFYFRTTDVTGVVQLPPGVEMVMPGDNVTFTVELIKP 378 Query: 433 VCTEVGEKIALSRRVEKHWRLIGWGQIRR 461 V E G + A+ R R +G G + + Sbjct: 379 VALEEGLRFAI--REGG--RTVGAGVVTK 403 >4ZV4-A nrPDB Length = 405 Score = 298 bits (762), Expect = 4e-81, Method: Composition-based stats. Identities = 101/453 (22%), Positives = 184/453 (40%), Gaps = 71/453 (15%) Query: 31 LSHEVISR-QATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIY 89 ++ E R + +N+GTIGHV HGK+T+ A++ V + + G + Sbjct: 1 MAKEKFERNKPHVNVGTIGHVDHGKTTLTAALTKVCSDTW------------GGSARAFD 48 Query: 90 KLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGA 149 ++D+ P + +++ E+ + + RH + VDCPGH + M+ GA Sbjct: 49 QIDN--APEEKARGITINTSHVEYDSAV----------RHYAHVDCPGHADYVKNMITGA 96 Query: 150 AVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILA 209 A MD A+L+ + + P PQT EH+ + + +I++ NK D+V +++ E E + Sbjct: 97 AQMDGAILVCSAADG-PMPQTREHILLSRQVGVPYIVVFLNKADMVDDAELLELVEMEVR 155 Query: 210 FVQGTV---AEGAPIIPISAQLKYN-----------IEVVCEYIVKKIPVPPRDFTSEPR 255 + T + PII SA + ++ + E + IP P R Sbjct: 156 DLLNTYDFPGDDTPIIIGSALMALEGKDDNGIGVSAVQKLVETLDSYIPEPVRAIDQPFL 215 Query: 256 LIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIF 315 + + F ++ +G V G + +G++KV +E+E+ V + K C + Sbjct: 216 MPIEDVFSISG--------RGTVVTGRVERGIIKVQEEVEI----VGIKATTKTTCTGV- 262 Query: 316 SKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISY 375 L G +G+ + R D GQVL G + + T+ E Sbjct: 263 ------EMFRKLLDEGRAGENVGILLR---GTKREDVERGQVLAKPGTI-KPHTKFECEV 312 Query: 376 FLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTN--PV 433 ++L + G R K + V G + D K+V+T P+ Sbjct: 313 YVLSKEEGGRHTPFFKG--YRPQFYFRTTDVTGNCELPEGVEMVMPGDNIKMVVTLIAPI 370 Query: 434 CTEVGEKIALSRRVEKHWRLIGWGQIRRGVTIK 466 E G + A+ R R +G G + + + ++ Sbjct: 371 AMEDGLRFAI--REGG--RTVGAGVVAKIIELE 399 >5W75-A nrPDB Length = 392 Score = 291 bits (745), Expect = 4e-79, Method: Composition-based stats. Identities = 99/437 (22%), Positives = 172/437 (39%), Gaps = 66/437 (15%) Query: 38 RQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCP 97 + +N+GTIGHV HGKST+ AI+ +++ G A Y D P Sbjct: 1 TKPHVNVGTIGHVDHGKSTLTAAITKYLSLK-------------GLAQYVPYDQIDK-AP 46 Query: 98 RPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALL 157 + + T E+ T+ RH + +DCPGH + M+ GAA MD A+L Sbjct: 47 EEKARGITINITHVEYETE----------KRHYAHIDCPGHADYIKNMITGAAQMDGAIL 96 Query: 158 LIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTV-- 215 ++A + P PQT EH+ + + ++++ NK D+V + + E E + + Sbjct: 97 VVAATDG-PMPQTREHVLLARQVGVPYMIVFINKTDMVDDPELIELVEMEVRDLLSQYEY 155 Query: 216 -AEGAPIIPISAQLKYN------------IEVVCEYIVKKIPVPPRDFTSEPRLIVIRSF 262 + P+I SA I+ + + + IP P RD + + F Sbjct: 156 PGDEVPVIKGSALKALEAPDDPNHEAYKPIQELLDAMDNYIPDPQRDVDKPFLMPIEDVF 215 Query: 263 DVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLF 322 + +G V G I +G ++ G E+E+ L + + + S+ Sbjct: 216 SITG--------RGTVVTGRIERGRIRPGDEVEIIG----------LSYEIRKTVVTSVE 257 Query: 323 AEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLL 382 +L G +G + + + + GQVL A G++ + + ++L++ Sbjct: 258 MFRKELDEGIAGDNVGCLLR---GIDKDEVERGQVLAAPGSI-KPHKRFKAEVYVLKKEE 313 Query: 383 GVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIA 442 G R K K Q + + I V +I L PV E G++ A Sbjct: 314 GGRHTPFFKGYKPQFYIRTTDVTGEIVLPEGVEMVMPGDHVEMEIELIYPVAIEKGQRFA 373 Query: 443 LSRRVEKHWRLIGWGQI 459 + R R +G G + Sbjct: 374 I--REGG--RTVGAGVV 386 >3WXM-A nrPDB Length = 447 Score = 291 bits (743), Expect = 6e-79, Method: Composition-based stats. Identities = 96/440 (21%), Positives = 174/440 (39%), Gaps = 84/440 (19%) Query: 36 ISRQATINIGTIGHVAHGKSTVVKAIS---GVHTVRFKNELERNITIKLGYANAKIYKLD 92 ++ + +N+ IGHV HGKST+V + G + ELE + + + LD Sbjct: 4 MAEKPHMNLVVIGHVDHGKSTLVGHLLYRLGYIEEKKLKELEEQAKSRGKESFKFAWILD 63 Query: 93 DPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHV-SFVDCPGHDILMATMLNGAAV 151 R I T F+ ++V + +D PGH + M+ GA+ Sbjct: 64 KMKEERERGI-------------TIDLTFMKFETKKYVFTIIDAPGHRDFVKNMITGASQ 110 Query: 152 MDAALLLIAGNESCP------QPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYE 205 DAA+L+++ + + QT EHL M ++ I++ NK+D + +++YE Sbjct: 111 ADAAILVVSARKGEFEAGMSTEGQTREHLLLARTMGIEQIIVAVNKMDAPDVNYDQKRYE 170 Query: 206 QILAFVQ------GTVAEGAPIIPISAQ------------LKYNIEVVCEYIVKKIPVPP 247 +++ ++ G + P IP+SA YN + E + + P P Sbjct: 171 FVVSVLKKFMKGLGYQVDKIPFIPVSAWKGDNLIERSPNMPWYNGPTLVEALDQLQP-PA 229 Query: 248 RDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEG 307 + R+ V + + G V G + GVL+VG ++ P Sbjct: 230 KPVDKPLRIPVQNVYSIPG--------AGTVPVGRVETGVLRVGDKVVFMP--------- 272 Query: 308 KLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEI 367 + ++ S+ + LQ A PG IG + + ++D G V G + P + Sbjct: 273 ----PGVVGEVRSIEMHYQQLQQAEPGDNIGFAVR---GVSKSDIKRGDVAGHLDKPPTV 325 Query: 368 FTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADL--- 424 E E F++ + + V+ V+ S+S+ R+ +KA L Sbjct: 326 AEEFEARIFVIWHPSAI------------TVGYTPVIHVHTASVSS--RIIEIKAKLDPK 371 Query: 425 -GKIVLTNPVCTEVGEKIAL 443 G++V NP + G+ + Sbjct: 372 TGQVVEQNPQFLKAGDAAIV 391 >3MMP-A nrPDB Length = 678 Score = 287 bits (733), Expect = 9e-78, Method: Composition-based stats. Identities = 106/451 (23%), Positives = 183/451 (40%), Gaps = 68/451 (15%) Query: 25 VTKLTPLSHEVISR-QATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGY 83 ++K + +S E R + +N+GTIGHV HGK+T+ AI+ V + G Sbjct: 279 MSKQSHMSKEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTY------------GG 326 Query: 84 ANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMA 143 A ++D+ P + +++ E+ T RH + VDCPGH + Sbjct: 327 AARAFDQIDN--APEEKARGITINTSHVEYDT----------PTRHYAHVDCPGHADYVK 374 Query: 144 TMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQ 203 M+ GAA MD A+L++A + P PQT EH+ + + +I++ NK D+V + + E Sbjct: 375 NMITGAAQMDGAILVVAATDG-PMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLEL 433 Query: 204 YEQILAFVQGTV---AEGAPIIPIS--------AQLKYNIEVVCEYIVKKIPVPPRDFTS 252 E + + + PI+ S A+ + I + ++ IP P R Sbjct: 434 VEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWEAKILELAGFLDSYIPEPERAIDK 493 Query: 253 EPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCK 312 L + F ++ +G V G + +G++KVG+E+E+ V K C Sbjct: 494 PFLLPIEDVFSISG--------RGTVVTGRVERGIIKVGEEVEI----VGIKETQKSTCT 541 Query: 313 PIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELE 372 + L G +GV + + R + GQVL G + + T+ E Sbjct: 542 GV-------EMFRKLLDEGRAGENVGVLLR---GIKREEIERGQVLAKPGTI-KPHTKFE 590 Query: 373 ISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTN- 431 ++L + G R K + V G + D K+V+T Sbjct: 591 SEVYILSKDEGGRHTPFFKG--YRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLI 648 Query: 432 -PVCTEVGEKIALSRRVEKHWRLIGWGQIRR 461 P+ + G + A+ R R +G G + + Sbjct: 649 HPIAMDDGLRFAI--REGG--RTVGAGVVAK 675 >4J0Q-A nrPDB Length = 433 Score = 278 bits (711), Expect = 3e-75, Method: Composition-based stats. Identities = 89/397 (22%), Positives = 158/397 (39%), Gaps = 68/397 (17%) Query: 20 LTTLDVTKLTPLSHEVISRQ------ATINIGTIGHVAHGKSTVVKAISGVHTVRFKNEL 73 + ++ + E ++++ +N+GTIGHV HGK+T+ A++ V + F Sbjct: 21 MASMTGGQQMGRGSEFMAKEKFDRSLPHVNVGTIGHVDHGKTTLTAALTRVCSEVF---- 76 Query: 74 ERNITIKLGYANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFV 133 G A + K+D S P + ++ E+ + I RH + V Sbjct: 77 --------GSAIVEFDKID--SAPEEKARGITINTAHVEYNSTI----------RHYAHV 116 Query: 134 DCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKID 193 DCPGH + M+ GAA MD A+L+ + + P PQT EH+ + + +I++ NK D Sbjct: 117 DCPGHADYVKNMITGAAQMDGAILVCSAADG-PMPQTREHILLSRQVGVPYIVVFLNKAD 175 Query: 194 LVKESQAKEQYEQILAFVQGTV---AEGAPIIPISAQLKYNIEV-----------VCEYI 239 LV +++ E E + + T + PII SA++ + + E + Sbjct: 176 LVDDAELLELVEMEVRDLLSTYDFPGDDTPIIIGSARMALEGKDDNEMGTTAVKKLVETL 235 Query: 240 VKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPG 299 IP P R + + F ++ +G V G I +G+++V +E+ Sbjct: 236 DSYIPEPVRAIDQPFLMPIEDVFSISG--------RGTVVTGRIERGIVRVQDPLEIVG- 286 Query: 300 IVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLG 359 + + + L G GV + R D GQVL Sbjct: 287 ----------LRDTTTTTCTGVEMFRKLLDEGRAGENCGVLLR---GTKRDDVERGQVLV 333 Query: 360 AVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQ 396 G++ + T+ ++L + G R K + Q Sbjct: 334 KPGSV-KPHTKFTAEVYVLSKEEGGRHTPFFKGYRPQ 369 >5W76-A nrPDB Length = 385 Score = 278 bits (710), Expect = 4e-75, Method: Composition-based stats. Identities = 101/442 (22%), Positives = 171/442 (38%), Gaps = 82/442 (18%) Query: 38 RQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCP 97 + +NIGTIGHV HGK+T+ AI+ V + G A K Y D P Sbjct: 1 TKPHVNIGTIGHVDHGKTTLTAAITKVLAEK-------------GQAEFKAYDQIDK-AP 46 Query: 98 RPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALL 157 + S+ E+ T+ RH + VDCPGH + M+ GAA MD A+L Sbjct: 47 EEKERGITISTAHVEYETE----------NRHYAHVDCPGHADYVKNMITGAAQMDGAIL 96 Query: 158 LIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTV-- 215 +++ + P PQT EH+ + + +I++ NK+D+V + + E E + + + Sbjct: 97 VVSAADG-PMPQTREHILLARQVGVPYIVVFLNKVDMVDDEELLELVEMEVRELLSSYDF 155 Query: 216 -AEGAPIIPISAQLKYNIEV--------VCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNK 266 + PII SA + + + + IP P R + + F ++ Sbjct: 156 PGDDIPIIKGSALKALEGDEEGEEAIMKLMDAVDSYIPEPERAIDKPFLMPIEDVFSIS- 214 Query: 267 PGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHN 326 +G V G + +G++KVG+E+E+ V K C + Sbjct: 215 --------RGTVVTGRVERGIVKVGEEVEI----VGIRDTQKTTCTGV-------EMFRK 255 Query: 327 DLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRT 386 L G +GV + R D GQVL G++ + T+ + ++L + G R Sbjct: 256 LLDEGQAGDNVGVLLR---GTKREDVERGQVLAKPGSI-KPHTKFKAEVYILTKEEGGRH 311 Query: 387 EGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADL---------GKIVLTNPVCTEV 437 + Q + G ++ + + L P+ E Sbjct: 312 TPFFNGYRPQ---------FYFRTTDVTGVITLPEGVEMVMPGDNVTITVELIAPIAMEE 362 Query: 438 GEKIALSRRVEKHWRLIGWGQI 459 G + A+ R R +G G + Sbjct: 363 GLRFAI--REGG--RTVGAGVV 380 >1D2E-A nrPDB Length = 397 Score = 275 bits (702), Expect = 3e-74, Method: Composition-based stats. Identities = 105/442 (23%), Positives = 175/442 (39%), Gaps = 81/442 (18%) Query: 39 QATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPR 98 + +N+GTIGHV HGK+T+ AI+ I + G A K Y+ D + P Sbjct: 1 KPHVNVGTIGHVDHGKTTLTAAIT-------------KILAEGGGAKFKKYEEID-NAPE 46 Query: 99 PECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLL 158 ++ E+ T RH + DCPGH + M+ G A +D +L+ Sbjct: 47 ERARGITINAAHVEYST----------AARHYAHTDCPGHADYVKNMITGTAPLDGCILV 96 Query: 159 IAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQ---GTV 215 +A N+ P PQT EHL + ++H+++ NK D V++S+ E E + + G Sbjct: 97 VAANDG-PMPQTREHLLLARQIGVEHVVVYVNKADAVQDSEMVELVELEIRELLTEFGYK 155 Query: 216 AEGAPIIPISAQLKYN----------IEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVN 265 E PII SA ++ + + + IPVP RD L V + + Sbjct: 156 GEETPIIVGSALCALEQRDPELGLKSVQKLLDAVDTYIPVPTRDLEKPFLLPVESVYSIP 215 Query: 266 KPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEH 325 +G V G++ +G+LK G E E K I + + + H Sbjct: 216 G--------RGTVVTGTLERGILKKGDECEFLG-----------HSKNIRTVVTGIEMFH 256 Query: 326 NDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVR 385 L A G +G + L R D G V+ G++ + ++E ++L + G R Sbjct: 257 KSLDRAEAGDNLGALVR---GLKREDLRRGLVMAKPGSI-QPHQKVEAQVYILTKEEGGR 312 Query: 386 TEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLG--------KIVLTNPVCTEV 437 + +S +M ++ + +L ++L P+ E Sbjct: 313 HKPF--------VSHFMPVMFSLTWDMACRIILPPGKELAMPGEDLKLTLILRQPMILEK 364 Query: 438 GEKIALSRRVEKHWRLIGWGQI 459 G++ L R R IG G + Sbjct: 365 GQRFTL--RDGN--RTIGTGLV 382 >5LZD-z nrPDB Length = 614 Score = 274 bits (699), Expect = 8e-74, Method: Composition-based stats. Identities = 97/415 (23%), Positives = 174/415 (41%), Gaps = 86/415 (20%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYR 103 I T GHV HGK+T+++AI+GV+ R E +R +TI LGYA P+P+ Sbjct: 3 IATAGHVDHGKTTLLQAITGVNADRLPEEKKRGMTIDLGYAY----------WPQPDG-- 50 Query: 104 SCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNE 163 R F+D PGH+ ++ ML G +D ALL++A ++ Sbjct: 51 ------------------------RVPGFIDVPGHEKFLSNMLAGVGGIDHALLVVACDD 86 Query: 164 SCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIP 223 QT EHLA +++ + + K D V E++ E Q+ ++ A + Sbjct: 87 GV-MAQTREHLAILQLTGNPMLTVALTKADRVDEARVDEVERQVKEVLREYGFAEAKLFI 145 Query: 224 ISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSI 283 +A ++ + E+++ ++P RL + R+F V G V G+ Sbjct: 146 TAATEGRGMDALREHLL-QLPEREHASQHSFRLAIDRAFTVKGAGL--------VVTGTA 196 Query: 284 LKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKI 343 L G +KVG + + + KP+ ++ +L A++ + A G I + Sbjct: 197 LSGEVKVGDSLWLTG-----------VNKPM--RVRALHAQNQPTETANAGQRIALNIAG 243 Query: 344 DP---TLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSK 400 D + R D ++ V PE FT R ++ ++T L++ Sbjct: 244 DAEKEQINRGDWLLADV------PPEPFT---------RVIVELQTH--------TPLTQ 280 Query: 401 NEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIG 455 + L ++ + GRVS ++ +L ++V P+ +++ L R + L G Sbjct: 281 WQPLHIHHAASHVTGRVSLLEDNLAELVFDTPLWLADNDRLVL-RDISARNTLAG 334 >1JNY-A nrPDB Length = 435 Score = 272 bits (696), Expect = 2e-73, Method: Composition-based stats. Identities = 92/433 (21%), Positives = 160/433 (36%), Gaps = 78/433 (18%) Query: 36 ISRQATINIGTIGHVAHGKSTVVKAI---SGVHTVRFKNELERNITIKLGYANAKIYKLD 92 +S++ +N+ IGHV HGKST+V + G + E E KLG + K L Sbjct: 1 MSQKPHLNLIVIGHVDHGKSTLVGRLLMDRGFIDEKTVKEAE-EAAKKLGKESEKFAFLL 59 Query: 93 DPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHV-SFVDCPGHDILMATMLNGAAV 151 D E I T F+ ++ + +D PGH + M+ GA+ Sbjct: 60 DRLKEE------------RERGVTINLTFMRFETKKYFFTIIDAPGHRDFVKNMITGASQ 107 Query: 152 MDAALLLIAGNES------CPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYE 205 DAA+L+++ + + QT EH+ + M L +++ NK+DL + +++Y+ Sbjct: 108 ADAAILVVSAKKGEYEAGMSVEGQTREHIILAKTMGLDQLIVAVNKMDLTEPPYDEKRYK 167 Query: 206 QI-----------------LAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPR 248 +I + FV G I S +K+ E + ++ +PP+ Sbjct: 168 EIVDQVSKFMRSYGFNTNKVRFVPVVAPSGDNITHKSENMKWYNGPTLEEYLDQLELPPK 227 Query: 249 DFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGK 308 R+ + + ++ G V G + GVLKVG +I P Sbjct: 228 PVDKPLRIPIQDVYSISGV--------GTVPVGRVESGVLKVGDKIVFMPA--------- 270 Query: 309 LMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIF 368 ++ S+ H + A PG IG + + + D G V+G P + Sbjct: 271 ----GKVGEVRSIETHHTKMDKAEPGDNIGFNVR---GVEKKDIKRGDVVGHPNNPPTVA 323 Query: 369 TELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSL--STGGRVSAVKADLGK 426 E ++ + VL V+ S+ VS + G+ Sbjct: 324 DEFTARIIVVWHPTALAN------------GYTPVLHVHTASVACRVSELVSKLDPRTGQ 371 Query: 427 IVLTNPVCTEVGE 439 NP + G+ Sbjct: 372 EAEKNPQFLKQGD 384 >1MJ1-A nrPDB Length = 405 Score = 270 bits (689), Expect = 1e-72, Method: Composition-based stats. Identities = 88/376 (23%), Positives = 148/376 (39%), Gaps = 67/376 (17%) Query: 34 EVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDD 93 E I + +N+GTIGHV HGK+T+ A++ V RN+ +K D Sbjct: 4 EFIRTKRHVNVGTIGHVDHGKTTLTAALTYVAAAE-----NRNVEVK--------DYGDI 50 Query: 94 PSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMD 153 ++ E+ T RH S VDC GH + M+ GAA MD Sbjct: 51 DKAREERARGITINTAHVEYET----------AKRHYSHVDCRGHADYIKNMITGAAQMD 100 Query: 154 AALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQG 213 A+L+++ + QT EH+ + +++I++ NK+D+V + + + E + + Sbjct: 101 GAILVVSAADG-RMRQTREHILLARQVGVRYIVVFMNKVDMVDDRELLDLVEMEVRDLLN 159 Query: 214 TV---AEGAPIIPISAQLKY------------------NIEVVCEYIVKKIPVPPRDFTS 252 + +I SA L I + + I + I RD Sbjct: 160 QYEFRGDEVRVIRGSALLALEEMHKNRKTKRGENEWVDKIWELLDAIDEYIRTRVRDVDK 219 Query: 253 EPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCK 312 + V F + +G VA G I +G +KVG E+E+ V E + Sbjct: 220 RFLMRVEDVFTITG--------RGTVATGRIERGKVKVGDEVEI----VGLARETRKTV- 266 Query: 313 PIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELE 372 + + LQ G +G+ + + R + GQVL G++ T+ E Sbjct: 267 -----VTGVEMHRKTLQEGIAGDNVGLLLR---GVSREEVERGQVLAKRGSITR-HTKFE 317 Query: 373 ISYFLLRRLLGVRTEG 388 S ++L++ G R G Sbjct: 318 ASVYILKKEEGGRHTG 333 >6MIJ-A nrPDB Length = 396 Score = 269 bits (686), Expect = 3e-72, Method: Composition-based stats. Identities = 94/442 (21%), Positives = 168/442 (38%), Gaps = 65/442 (14%) Query: 33 HEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLD 92 + + +N+GTIGHV HGK+T+ AI+ + + E + I Sbjct: 4 AKFERNKPHVNVGTIGHVDHGKTTLTAAIATICAKTYGGEAKDYSQID------------ 51 Query: 93 DPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVM 152 S P + +++ E+ + RH + VDCPGH + M+ GAA M Sbjct: 52 --SAPEEKARGITINTSHVEYDS----------PTRHYAHVDCPGHADYVKNMITGAAQM 99 Query: 153 DAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQ 212 D A+L+ A + P PQT EH+ + + +I++ NK DLV + + E E + + Sbjct: 100 DGAILVCAATDG-PMPQTREHILLSRQVGVPYIIVFLNKCDLVDDEELLELVEMEVRELL 158 Query: 213 GTV---AEGAPIIPISAQLKYNIE----------VVCEYIVKKIPVPPRDFTSEPRLIVI 259 T + P+I SA N E + + IP P R + + Sbjct: 159 STYDFPGDDTPVIRGSALAALNGEAGPYGEESVLALVAALDSYIPEPERAIDKAFLMPIE 218 Query: 260 RSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIV 319 F ++ +G V G + G++KVG+E+E+ + + + + Sbjct: 219 DVFSISG--------RGTVVTGRVEAGIIKVGEEVEIVG-----------IKDTVKTTVT 259 Query: 320 SLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLR 379 + L G G+ + R + GQVL G + + T+ + ++L Sbjct: 260 GVEMFRKLLDEGRAGENCGILLR---GTKREEVQRGQVLAKPGTI-KPHTKFDAEVYVLS 315 Query: 380 RLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGE 439 + G R + Q + + I V + L +P+ + G Sbjct: 316 KEEGGRHTPFLNGYRPQFYFRTTDVTGAIQLKEGVEMVMPGDNVEMSVELIHPIAMDPGL 375 Query: 440 KIALSRRVEKHWRLIGWGQIRR 461 + A+ R R +G G + + Sbjct: 376 RFAI--REGG--RTVGAGVVAK 393 >5W7Q-A nrPDB Length = 373 Score = 268 bits (684), Expect = 4e-72, Method: Composition-based stats. Identities = 103/436 (23%), Positives = 169/436 (38%), Gaps = 76/436 (17%) Query: 37 SRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSC 96 + +NIGTIGHV HGK+T+ AI+ V + G A AK Y D + Sbjct: 1 RTKPHVNIGTIGHVDHGKTTLTAAITTVLAKK-------------GGAEAKAYDQID-NA 46 Query: 97 PRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAAL 156 P + ++ E+ T+ RH + VDCPGH + M+ GAA MD A+ Sbjct: 47 PEEKARGITINTAHVEYETE----------NRHYAHVDCPGHADYVKNMITGAAQMDGAI 96 Query: 157 LLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTV- 215 L+++ + P PQT EH+ + + +I++ NK D+V + + E E + + Sbjct: 97 LVVSAADG-PMPQTREHILLARQVGVPYIVVFLNKCDMVDDEELLELVEMEVRELLSEYD 155 Query: 216 --AEGAPIIPISAQLKYNIE--------VVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVN 265 + PII SA + + + + IP P RD + + F ++ Sbjct: 156 FPGDDIPIIRGSALKALEGDAEWEDKILELMDAVDSYIPTPERDIDKPFLMPIEDVFSIS 215 Query: 266 KPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEH 325 +G V G + +G++KVG+E+E+ V K + Sbjct: 216 G--------RGTVVTGRVERGIVKVGEEVEI----VGIKDTQKTTVTGVEM--------- 254 Query: 326 NDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVR 385 G + GTK R D GQVL G++ T+ E ++L + G R Sbjct: 255 --------VGALLRGTK------REDVERGQVLAKPGSI-TPHTKFEAEVYVLSKEEGGR 299 Query: 386 TEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSR 445 + Q + + I V + L P+ E G + A+ Sbjct: 300 HTPFFNGYRPQFYFRTTDVTGVIELPEGVEMVMPGDNVKMTVELIAPIAMEEGLRFAI-- 357 Query: 446 RVEKHWRLIGWGQIRR 461 R R +G G + + Sbjct: 358 REGG--RTVGAGVVSK 371 >1EFM-A nrPDB Length = 379 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 101/444 (22%), Positives = 170/444 (38%), Gaps = 82/444 (18%) Query: 32 SHEVISR-QATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYK 90 S E R + +N+GTIGHV HGK+T+ AI+ V + Sbjct: 1 SKEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGG------------------- 41 Query: 91 LDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAA 150 +++ E+ T RH + VDCPGH + M+ GAA Sbjct: 42 ---------AARGITINTSHVEYDT----------PTRHYAHVDCPGHADYVKNMITGAA 82 Query: 151 VMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAF 210 MD A+L++A + P PQT EH+ + + +I++ NK D+V + + E E + Sbjct: 83 QMDGAILVVAATDG-PMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRE 141 Query: 211 VQGTV---AEGAPIIPIS--------AQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVI 259 + + PI+ S A+ + I + ++ IP P R L + Sbjct: 142 LLSQYDFPGDDTPIVRGSALKALEGDAEWEAKILELAGFLDSYIPEPERAIDKPFLLPIE 201 Query: 260 RSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIV 319 F ++ +G V G + +G++KVG+E+E+ V K C + Sbjct: 202 DVFSISG--------RGTVVTGRVERGIIKVGEEVEI----VGIKETQKSTCTGV----- 244 Query: 320 SLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLR 379 L G +GV + + R + GQVL G + + T+ E ++L Sbjct: 245 --EMFRKLLDEGRAGENVGVLLR---GIKREEIERGQVLAKPGTI-KPHTKFESEVYILS 298 Query: 380 RLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTN--PVCTEV 437 + G R K + V G + D K+V+T P+ + Sbjct: 299 KDEGGRHTPFFKG--YRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDD 356 Query: 438 GEKIALSRRVEKHWRLIGWGQIRR 461 G + A+ R R +G G + + Sbjct: 357 GLRFAI--REGG--RTVGAGVVAK 376 >3WY9-A nrPDB Length = 434 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 94/436 (21%), Positives = 156/436 (35%), Gaps = 76/436 (17%) Query: 37 SRQATINIGTIGHVAHGKSTV-------VKAISGVHTVRFKNELERNITIKLGYANAKIY 89 + +NI IGHV HGKST I +F+ E+ + K + ++ Sbjct: 3 KEKPHVNIVFIGHVDHGKSTTIGRLLYDTGNIPETIIKKFEEMGEKGKSFKFAWVMDRL- 61 Query: 90 KLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGA 149 +F T R+++ +D PGH + M+ GA Sbjct: 62 -------KEERERGITIDVAHTKFET----------PHRYITIIDAPGHRDFVKNMITGA 104 Query: 150 AVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQ--AKEQYEQI 207 + DAA+L++A + PQT EH + +KHI++ NK+D+V Q ++ Q+ Sbjct: 105 SQADAAVLVVAATDGV-MPQTKEHAFLARTLGIKHIIVTINKMDMVNYDQKVFEKVKAQV 163 Query: 208 LAFVQGTVAEGAPIIPISAQ------------LKYNIEVVCEYIVKKIPVPPRDFTSEPR 255 ++ + P+IP SA YN + E + +IP P + R Sbjct: 164 EKLLKTLGYKDFPVIPTSAWNGDNVVKKSDKMPWYNGPTLIEALD-QIPEPEKPIDKPLR 222 Query: 256 LIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIF 315 + + + + G V G + G LKVG + P + KPI Sbjct: 223 IPIQDVYSIKGV--------GTVPVGRVETGKLKVGDVVIFEPA-------STIFHKPIQ 267 Query: 316 SKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEI---FTELE 372 ++ S+ H LQ A PG IG + + + D G V G P + + Sbjct: 268 GEVKSIEMHHEPLQEALPGDNIGFNVR---GVSKNDIKRGDVAGHTDKPPTVVRTKDTFK 324 Query: 373 ISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKAD--LGKIVLT 430 +L + + + VL + + K D G IV Sbjct: 325 AQIIVLNHPTAI------------TVGYSPVLHAHTAQIPVRFEQILAKVDPRTGNIVEE 372 Query: 431 NPVCTEVGEKIALSRR 446 NP + G+ + R Sbjct: 373 NPQFIKTGDSAIVVLR 388 >5IZL-A nrPDB Length = 616 Score = 238 bits (606), Expect = 5e-63, Method: Composition-based stats. Identities = 94/409 (22%), Positives = 165/409 (40%), Gaps = 73/409 (17%) Query: 28 LTPLSHEVISRQATINIGTIGHVAHGKSTVVKAISGVHT----VRFKNELERNITIKLGY 83 L P + R+ +N+G +GH+ GK+ + +A+S + + ER IT+ LG+ Sbjct: 14 LVPRGSHMAGRRVNVNVGVLGHIDSGKTALARALSTTASTAAFDKQPQSRERGITLDLGF 73 Query: 84 ANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMA 143 + S P P RS + EF + + V+ VDCPGH L+ Sbjct: 74 SCF--------SVPLPARLRS----SLPEFQAAPEAEPEPGEPLLQVTLVDCPGHASLIR 121 Query: 144 TMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQ 203 T++ GA ++D +L+I + Q Q++E L +I K ++++ NKIDL+ E + + Sbjct: 122 TIIGGAQIIDLMMLVIDVTKGM-QTQSAECLVIGQIACQK-LVVVLNKIDLLPEGKRQAA 179 Query: 204 YEQILAFVQG----TVAEGAPIIPISAQLK----------YNIEVVCEYIVKKIPVPPRD 249 +++ +Q T GAPIIP++A+ I + E + +I +P RD Sbjct: 180 IDKMTKKMQKTLENTKFRGAPIIPVAAKPGGPEAPETEAPQGIPELIELLTSQISIPTRD 239 Query: 250 FTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKL 309 + + V F + +G V G+IL G + +G +E+ Sbjct: 240 PSGPFLMSVDHCFSIKG--------QGTVMTGTILSGSISLGDSVEIP------------ 279 Query: 310 MCKPIFSKIVSLFAEHNDLQYAAPGGLIGVG-TKIDPTLCRADRMVGQVLGAVGALPEIF 368 + K+ S+ H + A G +G+ T+ DP L G V +L + Sbjct: 280 -ALKVVKKVKSMQMFHMPITSAMQGDRLGICVTQFDPKL----LERGLVCA-PESLHTVH 333 Query: 369 TELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRV 417 L +K L + +G + GR+ Sbjct: 334 AAL--------------ISVEKIPYFRGPLQTKAKFHITVGHETVMGRL 368 >2HDN-B nrPDB Length = 335 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 84/372 (22%), Positives = 146/372 (39%), Gaps = 53/372 (14%) Query: 103 RSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGN 162 +++ E+ T RH + VDCPGH + M+ GAA MD A+L++A Sbjct: 1 GITINTSHVEYDT----------PTRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAAT 50 Query: 163 ESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTV---AEGA 219 + P PQT EH+ + + +I++ NK D+V + + E E + + + Sbjct: 51 DG-PMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDT 109 Query: 220 PIIPIS--------AQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEV 271 PI+ S A+ + I + ++ IP P R L + F ++ Sbjct: 110 PIVRGSALKALEGDAEWEAKILELAGFLDSYIPEPERAIDKPFLLPIEDVFSISG----- 164 Query: 272 DDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYA 331 +G V G + +G++KVG+E+E+ V K C + L Sbjct: 165 ---RGTVVTGRVERGIIKVGEEVEI----VGIKETQKSTCTGV-------EMFRKLLDEG 210 Query: 332 APGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKK 391 G +GV + + R + GQVL G + + T+ E ++L + G R K Sbjct: 211 RAGENVGVLLR---GIKREEIERGQVLAKPGTI-KPHTKFESEVYILSKDEGGRHTPFFK 266 Query: 392 AAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTN--PVCTEVGEKIALSRRVEK 449 + V G + D K+V+T P+ + G + A+ R Sbjct: 267 G--YRPQFYFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAI--REGG 322 Query: 450 HWRLIGWGQIRR 461 R +G G + + Sbjct: 323 --RTVGAGVVAK 332 >4C0S-A nrPDB Length = 463 Score = 220 bits (560), Expect = 9e-58, Method: Composition-based stats. Identities = 81/451 (17%), Positives = 148/451 (32%), Gaps = 95/451 (21%) Query: 37 SRQATINIGTIGHVAHGKSTVVKAIS---GVHTVRFKNELERNITIKLGYANAKIYKLDD 93 + INI IGHV GKST + G R + E+ + + LD Sbjct: 3 KEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDK 62 Query: 94 PSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMD 153 R S E +++ +D PGH + M+ G + D Sbjct: 63 LKAERERGITIDISLWKFE------------TTKYYITIIDAPGHRDFIKNMITGTSQAD 110 Query: 154 AALLLIAGNESCPQ------PQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQI 207 A+L++A + QT EH + +K +++ NK+D + + ++++Y++I Sbjct: 111 CAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPAYSEKRYDEI 170 Query: 208 LAFVQ------GTVAEGAPIIPISAQLKYNIEV------------------------VCE 237 + V G P +PIS N+ + E Sbjct: 171 VKEVSAYIKKIGYNPATVPFVPISGWHGDNMLEPSPNMPWFKGWKVERKEGNASGVSLLE 230 Query: 238 YIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVR 297 + +P P R RL + + + G V G + G+L+ G + Sbjct: 231 ALDTILP-PTRPTDKPLRLPLQDVYKIGGI--------GTVPVGRVETGILRPGMVVTFA 281 Query: 298 PGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQV 357 P I +++ S+ H L A PG +G K + D G V Sbjct: 282 P-------------VNITTEVKSVEMHHEALSEALPGDNVGFNVK---NVSVKDIRRGNV 325 Query: 358 LG-AVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGR 416 G + P+ + +L + + V+ + + + Sbjct: 326 CGDSKSDPPQEAAQFTSQVIILNHPGQISA------------GYSPVIDCH--TAHIACK 371 Query: 417 VSAVKADL----GKIVLTNPVCTEVGEKIAL 443 + +K + GK + NP + G+ + Sbjct: 372 FAELKEKIDRRSGKKLEDNPKSLKSGDAAIV 402 >5LZS-jj nrPDB Length = 462 Score = 218 bits (555), Expect = 4e-57, Method: Composition-based stats. Identities = 83/451 (18%), Positives = 143/451 (31%), Gaps = 95/451 (21%) Query: 37 SRQATINIGTIGHVAHGKSTVVKAIS---GVHTVRFKNELERNITIKLGYANAKIYKLDD 93 + INI IGHV GKST + G R + E+ + + LD Sbjct: 3 KEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDK 62 Query: 94 PSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMD 153 R S E +V+ +D PGH + M+ G + D Sbjct: 63 LKAERERGITIDISLWKFE------------TSKYYVTIIDAPGHRDFIKNMITGTSQAD 110 Query: 154 AALLLIAGNESCPQ------PQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQI 207 A+L++A + QT EH + +K +++ NK+D + ++++YE+I Sbjct: 111 CAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEI 170 Query: 208 LAFVQ------GTVAEGAPIIPISAQLKYNIEV------------------------VCE 237 + V G + +PIS N+ + E Sbjct: 171 VKEVSTYIKKIGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGNASGTTLLE 230 Query: 238 YIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVR 297 + +P P R RL + + + G V G + GVLK G + Sbjct: 231 ALDCILP-PTRPTDKPLRLPLQDVYKIGGI--------GTVPVGRVETGVLKPGMVVTFA 281 Query: 298 PGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQV 357 P + +++ S+ H L A PG +G K + D G V Sbjct: 282 P-------------VNVTTEVKSVEMHHEALSEALPGDNVGFNVK---NVSVKDVRRGNV 325 Query: 358 LG-AVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGR 416 G + P +L + VL + + + Sbjct: 326 AGDSKNDPPMEAAGFTAQVIILNHPGQISA------------GYAPVLDCH--TAHIACK 371 Query: 417 VSAVKADL----GKIVLTNPVCTEVGEKIAL 443 + +K + GK + P + G+ + Sbjct: 372 FAELKEKIDRRSGKKLEDGPKFLKSGDAAIV 402 >2B7C-A nrPDB Length = 458 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 85/443 (19%), Positives = 147/443 (33%), Gaps = 89/443 (20%) Query: 37 SRQATINIGTIGHVAHGKSTVVKAIS---GVHTVRFKNELERNITIKLGYANAKIYKLDD 93 ++ IN+ IGHV GKST + G R + E+ + + LD Sbjct: 3 KEKSHINVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDK 62 Query: 94 PSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMD 153 R + E P V+ +D PGH + M+ G + D Sbjct: 63 LKAERERGITIDIALWKFETP------------KYQVTVIDAPGHRDFIKNMITGTSQAD 110 Query: 154 AALLLIAGNESCPQ------PQTSEHLAAIEIMKLKHILILQNKIDLV--KESQAKEQYE 205 A+L+IAG + QT EH + ++ +++ NK+D V ES+ +E + Sbjct: 111 CAILIIAGGVGEFEAGISKDGQTREHALLAFTLGVRQLIVAVNKMDSVKWDESRFQEIVK 170 Query: 206 QILAFVQ--GTVAEGAPIIPISAQLKYNI------------------------EVVCEYI 239 + F++ G + P +PIS N+ + + E I Sbjct: 171 ETSNFIKKVGYNPKTVPFVPISGWNGDNMIEATTNAPWYKGWEKETKAGVVKGKTLLEAI 230 Query: 240 VKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPG 299 I P R RL + + + G V G + GV+K G + P Sbjct: 231 DA-IEQPSRPTDKPLRLPLQDVYKIGGI--------GTVPVGRVETGVIKPGMVVTFAPA 281 Query: 300 IVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLG 359 + +++ S+ H L+ PG +G K + + G V G Sbjct: 282 -------------GVTTEVKSVEMHHEQLEQGVPGDNVGFNVK---NVSVKEIRRGNVCG 325 Query: 360 -AVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVS 418 A P+ + +L + + VL + ++ Sbjct: 326 DAKNDPPKGCASFNATVIVLNHPGQISA------------GYSPVLDCHTAHIACRFDEL 373 Query: 419 AVKADL--GKIVLTNPVCTEVGE 439 K D GK + +P + G+ Sbjct: 374 LEKNDRRSGKKLEDHPKFLKSGD 396 >4ZU9-A nrPDB Length = 582 Score = 208 bits (530), Expect = 3e-54, Method: Composition-based stats. Identities = 80/403 (19%), Positives = 142/403 (35%), Gaps = 82/403 (20%) Query: 42 INIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPEC 101 I T GHV HGK+T++K ++G+ T R E +R ++I +G+A ++ Sbjct: 4 ILFATAGHVDHGKTTLIKTLTGIDTDRLPEEKKRGLSIDIGFAYIDFPDINT-------- 55 Query: 102 YRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAG 161 + +D PGH+ + + G +L++ Sbjct: 56 ---------------------------RLEIIDVPGHERFIKNAIAGICSASGLILVVDP 88 Query: 162 NESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPI 221 NE PQT EHL + +KH + + K+D V E A E+++AF++ I Sbjct: 89 NEGI-MPQTIEHLRVAKSFGIKHGIAVLTKMDKVDEELAHIAEEELIAFLEKE-EMNMEI 146 Query: 222 IPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEP-RLIVIRSFDVNKPGCEVDDLKGGVAG 280 + +SA IE + I K + +P R+ V +F V G V Sbjct: 147 VKVSAVTGQGIEDLKNSIKKLLESINNLNKHKPLRIFVDSAFVVKGY--------GTVLR 198 Query: 281 GSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVG 340 GS +G +K G ++ V P + S++ + ++ A G I + Sbjct: 199 GSCFEGEVKEGDKVVVEP-------------IGVISRVRKMQNHGVFVKKAVAGERIALN 245 Query: 341 TKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSK 400 P + G FL+ + L Sbjct: 246 L---PEVDAKKVKRG--------------------FLILKPESYEKSNVLIVKTEIDLKP 282 Query: 401 NEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIAL 443 ++ V G T G++S + + + L G+K+ + Sbjct: 283 GKIYQVFFGMRETVGKISVIDKGIYLVRLKENAIVRRGDKLVV 325 >4D61-i nrPDB Length = 426 Score = 207 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 75/426 (17%), Positives = 154/426 (36%), Gaps = 60/426 (14%) Query: 39 QATINIGTIGHVAHGKSTV---VKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPS 95 + +N+ IGHV GKST+ + ++G+ R + ER K + LD Sbjct: 1 KEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQ 60 Query: 96 CPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAA 155 R + T G +H + +D PGH + M+ GA+ D A Sbjct: 61 EERDKG------------KTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLA 108 Query: 156 LLLIAGNESCPQP------QTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQ--- 206 +L+I+ + + QT EH + +KH+++L NK+D + + E+YE+ Sbjct: 109 VLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEECKE 168 Query: 207 -ILAFVQGTVA---EGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSE-PRLIVIRS 261 ++ F++ + +P S N++ ++ I +P + P Sbjct: 169 KLVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWYIGLPFIPYLDNLPNFNRSVD 228 Query: 262 FDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSL 321 + P + G V G + G + GQ++ + P +++ + Sbjct: 229 GPIRLPIVDKYKDMGTVVLGKLESGSICKGQQLVMMP-------------NKHNVEVLGI 275 Query: 322 FAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRL 381 ++ + APG + + K + + + G +L L + ++ Sbjct: 276 LSDDVETDTVAPGENLKIRLK---GIEEEEILPGFILCDPNNLCHSGRTFDAQIVIIEHK 332 Query: 382 LGVRTEGDKKAAKVQKLSKNEVLMVN--IGSLSTGGRVSAVKADLGKIVLTNPVCTEVGE 439 + N VL ++ I + + V G+ T P + + Sbjct: 333 S------------IICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPRFVK-QD 379 Query: 440 KIALSR 445 ++ ++R Sbjct: 380 QVCIAR 385 >5LZT-jj nrPDB Length = 637 Score = 207 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 75/427 (17%), Positives = 155/427 (36%), Gaps = 60/427 (14%) Query: 38 RQATINIGTIGHVAHGKSTV---VKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDP 94 ++ +N+ IGHV GKST+ + ++G+ R + ER K + LD Sbjct: 209 KKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTN 268 Query: 95 SCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDA 154 R + T G +H + +D PGH + M+ GA+ D Sbjct: 269 QEERDKG------------KTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADL 316 Query: 155 ALLLIAGNESCPQP------QTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQ-- 206 A+L+I+ + + QT EH + +KH+++L NK+D + + E+YE+ Sbjct: 317 AVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEECK 376 Query: 207 --ILAFVQGTVA---EGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSE-PRLIVIR 260 ++ F++ + +P S N++ ++ I +P + P Sbjct: 377 EKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWYIGLPFIPYLDNLPNFNRSV 436 Query: 261 SFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVS 320 + P + G V G + G + GQ++ + P +++ Sbjct: 437 DGPIRLPIVDKYKDMGTVVLGKLESGSICKGQQLVMMP-------------NKHNVEVLG 483 Query: 321 LFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRR 380 + ++ + APG + + K + + + G +L L + ++ Sbjct: 484 ILSDDVETDTVAPGENLKIRLK---GIEEEEILPGFILCDPNNLCHSGRTFDAQIVIIEH 540 Query: 381 LLGVRTEGDKKAAKVQKLSKNEVLMVN--IGSLSTGGRVSAVKADLGKIVLTNPVCTEVG 438 + N VL ++ I + + V G+ T P + Sbjct: 541 KS------------IICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPRFVK-Q 587 Query: 439 EKIALSR 445 +++ ++R Sbjct: 588 DQVCIAR 594 >4AC9-A nrPDB Length = 482 Score = 201 bits (510), Expect = 6e-52, Method: Composition-based stats. Identities = 84/442 (19%), Positives = 165/442 (37%), Gaps = 79/442 (17%) Query: 41 TINIGTIGHVAHGKSTVVKAISGVHT----VRFKNELERNITIKLGYANAKIYKLDDPSC 96 IN+G GH+ HGK+T+ K ++ + + + +R ITI +G++ K+ Sbjct: 19 NINLGIFGHIDHGKTTLSKVLTEIASTSAHDKLPESQKRGITIDIGFSAFKLENY----- 73 Query: 97 PRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAAL 156 ++ VD PGH L+ +++ A ++D AL Sbjct: 74 --------------------------------RITLVDAPGHADLIRAVVSAADIIDLAL 101 Query: 157 LLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGT-V 215 +++ E P+ QT EH+ ++ + I+++ K D + K + + +Q T Sbjct: 102 IVVDAKEG-PKTQTGEHMLILDHFNIP-IIVVITKSDNAGTEEIKRTEMIMKSILQSTHN 159 Query: 216 AEGAPIIPISAQLKYNIEVVCEYIVKKIPVPP--RDFTSEPRLIVIRSFDVNKPGCEVDD 273 + + IIPISA+ + ++ + I+ + R+ S ++ + +F + Sbjct: 160 LKNSSIIPISAKTGFGVDELKNLIITTLNNAEIIRNTESYFKMPLDHAFPIKG------- 212 Query: 274 LKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAP 333 G V G+I KG++KVG E++V P + +K+ S+ + A Sbjct: 213 -AGTVVTGTINKGIVKVGDELKVLP-------------INMSTKVRSIQYFKESVMEAKA 258 Query: 334 GGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAA 393 G +G+ + + G +L + + ++ + T K Sbjct: 259 GDRVGMAIQ---GVDAKQIYRGCILTSKDTKLQTVDKIVAKIKISDIFKYNLTPKMKVHL 315 Query: 394 KVQ-------KLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSR- 445 V + +V V + L V EVG+++ ++R Sbjct: 316 NVGMLIVPAVAVPFKKVTFGKTEENIILNEVISGNECYCAFELEEKVLAEVGDRVLITRL 375 Query: 446 -RVEKHWRLIGWGQIRRGVTIK 466 R+ G G I IK Sbjct: 376 DLPPTTLRICGHGLIEEFKPIK 397 >1ZUN-B nrPDB Length = 434 Score = 189 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 80/440 (18%), Positives = 153/440 (34%), Gaps = 58/440 (13%) Query: 17 RQDLTTLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERN 76 + DL + D+ L L R+ + T G+V GKST++ + + +++ LE Sbjct: 4 QSDLISEDI--LAYLGQH--ERKEMLRFLTCGNVDDGKSTLIGRLLHDSKMIYEDHLEAI 59 Query: 77 ITIKLGYANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCP 136 + R G + + + R D P Sbjct: 60 TRDSKKSGTTGDDVDLALLVDGLQAEREQGITIDVAY-------RYFSTAKRKFIIADTP 112 Query: 137 GHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVK 196 GH+ M GA+ D A++L+ Q QT H ++ +KHI++ NK+DL Sbjct: 113 GHEQYTRNMATGASTCDLAIILVDARYGV-QTQTRRHSYIASLLGIKHIVVAINKMDLNG 171 Query: 197 ESQ-----AKEQYEQI----------LAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVK 241 + K Y + +AFV + +G ++ S + + I++ Sbjct: 172 FDERVFESIKADYLKFAEGIAFKPTTMAFVPMSALKGDNVVNKSERSPWYAGQSLMEILE 231 Query: 242 KIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIV 301 + + ++ R V VN+P G +A G + KG EI V P Sbjct: 232 TVEIASDRNYTDLRFPVQY---VNRPNLNFRGFAGTLASGIVHKG-----DEIVVLPS-- 281 Query: 302 SKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAV 361 S++ S+ +L+ A PG + + + + + R D +V Sbjct: 282 -----------GKSSRVKSIVTFEGELEQAGPGQAVTLTMEDEIDISRGDLLV-----HA 325 Query: 362 GALPEIFTELEISYFLLRRL--LGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSA 419 +P++ + + L + K+A S + + G S+ Sbjct: 326 DNVPQVSDAFDAMLVWMAEEPMLPGKKYDIKRATSYVPGSIASITHRVDVNTLEEGPASS 385 Query: 420 VKADLG---KIVLTNPVCTE 436 ++ + K+ L P+ + Sbjct: 386 LQLNEIGRVKVSLDAPIALD 405 >1R5O-A nrPDB Length = 467 Score = 187 bits (474), Expect = 8e-48, Method: Composition-based stats. Identities = 79/436 (18%), Positives = 144/436 (33%), Gaps = 77/436 (17%) Query: 39 QATINIGTIGHVAHGKSTVVKAI---SGVHTVRFKNELERNITIKLGYANAKIYKLDDPS 95 + +NI IGHV GKST+ I +G+ R ++ER + + LD S Sbjct: 41 KEHVNIVFIGHVDAGKSTLGGNILFLTGMVDKRTMEKIEREAKEAGKESWYLSWALDSTS 100 Query: 96 CPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAA 155 R + T G R S +D PGH + M+NGA+ D Sbjct: 101 EEREKG------------KTVEVGRAYFETEHRRFSLLDAPGHKGYVTNMINGASQADIG 148 Query: 156 LLLIAGNESCPQ------PQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQ--- 206 +L+I+ + QT EH + H++++ NK+D ++E+Y++ Sbjct: 149 VLVISARRGEFEAGFERGGQTREHAVLARTQGINHLVVVINKMDEPSVQWSEERYKECVD 208 Query: 207 ----ILAFVQGTVAE-GAPIIPISAQLKYNI--------------EVVCEYIVKKIPVPP 247 L V G ++ +P+SA N+ + EY+ + Sbjct: 209 KLSMFLRRVAGYNSKTDVKYMPVSAYTGQNVKDRVDSSVCPWYQGPSLLEYLDSMTHL-E 267 Query: 248 RDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEG 307 R + + + + G + G I G +K + V P + + Sbjct: 268 RKVNAPFIMPIASKY----------KDLGTILEGKIEAGSIKKNSNVLVMPINQTLEVTA 317 Query: 308 KLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEI 367 ++ + G + + + D +D G VL + Sbjct: 318 IY------------DEADEEISSSICGDQVRLRVRGDD----SDVQTGYVLTSTKNPVHA 361 Query: 368 FTELEISYFLLRRLLGVRTEGDKKA---AKVQKLSKNEVLM----VNIGSLSTGGRVSAV 420 T +L + T V+++S ++L N S + Sbjct: 362 TTRFIAQIAILELPSILTTGYSCVMHIHTAVEEVSFAKLLHKLDKTNRKSKKPPMFATKG 421 Query: 421 KADLGKIVLTNPVCTE 436 + ++ PVC E Sbjct: 422 MKIIAELETQTPVCME 437 >5LZY-jj nrPDB Length = 710 Score = 170 bits (431), Expect = 8e-43, Method: Composition-based stats. Identities = 73/447 (16%), Positives = 142/447 (31%), Gaps = 87/447 (19%) Query: 37 SRQATINIGTIGHVAHGKSTVVKA---ISGVHTVRFKNELERNITIKLGYANAKIYKLDD 93 + +N+ IGHV GKST++ + G R ++ E+ + A + LD+ Sbjct: 282 GGKQLLNLVVIGHVDAGKSTLMGHMLYLLGNINKRTMHKYEQESKKAGKASFAYAWVLDE 341 Query: 94 PSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMD 153 R T E T + ++ +D PGH + M+ GAA D Sbjct: 342 TGEERERGVTMDVGMTKFETTTKV------------ITLMDAPGHKDFIPNMITGAAQAD 389 Query: 154 AALLLIAGNESCPQ------PQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQI 207 A+L++ + + QT EH + + + + + NK+D V + +E++++I Sbjct: 390 VAVLVVDASRGEFEAGFETGGQTREHGLLVRSLGVTQLAVAVNKMDQV--NWQQERFQEI 447 Query: 208 LAFV------QGTVAEGAPIIPISAQLKYNIEV---------------VCEYIVKKIPVP 246 + G IP S N+ + E I P P Sbjct: 448 TGKLGHFLKQAGFKESDVGFIPTSGLSGENLITRSQSSELTKWYKGLCLLEQIDSFKP-P 506 Query: 247 PRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSE 306 R RL V F D G G I G ++ G + P Sbjct: 507 QRSIDKPFRLCVSDVFK--------DQGSGFCITGKIEAGYIQTGDRLLAMP-------- 550 Query: 307 GKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPE 366 + + + +AA G + + + VG + + Sbjct: 551 -----PNETCTVKGITLHDEPVDWAAAGDHVSLTLVGMDIIK---INVGCIFCGPKVPIK 602 Query: 367 IFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGR----VSAVKA 422 T + + ++K ++++ ++S +S + Sbjct: 603 ACTRFRARILIFNIEI--------------PITKGFPVLLHYQTVSEPAVIKRLISVLNK 648 Query: 423 DLGKIVLTNPVCTEVGEKIALSRRVEK 449 G++ P G+ + + ++ Sbjct: 649 STGEVTKKKPKFLTKGQNALVELQTQR 675 >2YWH-A nrPDB Length = 600 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 78/345 (22%), Positives = 120/345 (34%), Gaps = 75/345 (21%) Query: 36 ISRQATINIGTIGHVAHGKSTVVKAI---SGVHTVRFKNE---------LERNITIKLGY 83 + ++ N I HV HGKST+ + +G + R K E ER IT+K+ Sbjct: 1 MEQKNVRNFCIIAHVDHGKSTLADRLLEYTGAISEREKREQLLDTLDVERERGITVKMQ- 59 Query: 84 ANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMA 143 A YK D + + + +D PGH Sbjct: 60 AVRMFYKAKDGNTYK-------------------------------LHLIDTPGHVDFSY 88 Query: 144 TMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLV--KESQAK 201 + A + ALLLI ++ + A+E + I+ + NKIDL + K Sbjct: 89 EVSRALAACEGALLLIDASQGIEAQTVANFWKAVEQDLV--IIPVINKIDLPSADVDRVK 146 Query: 202 EQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRS 261 +Q E++L G E A I SA+ IE + E IV +IP P D + ++ S Sbjct: 147 KQIEEVL----GLDPEEA--ILASAKEGIGIEEILEAIVNRIPPPKGDPQKPLKALIFDS 200 Query: 262 FDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSL 321 + D +G VA I G +K G +I + + P +K L Sbjct: 201 Y--------YDPYRGAVAFVRIFDGEVKPGDKIMLMSTGKEYEVTEVGAQTPKMTKFDKL 252 Query: 322 FAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPE 366 A G I K D +G + + Sbjct: 253 --------SAGDVGYIAASIKDVR-----DIRIGDTITHAKNPTK 284 >3MCA-A nrPDB Length = 592 Score = 155 bits (392), Expect = 3e-38, Method: Composition-based stats. Identities = 60/345 (17%), Positives = 118/345 (34%), Gaps = 60/345 (17%) Query: 29 TPLSHEVISRQATINIGTIGHVAHGKSTVVKAIS---GVHTVRFKNELERNITIKLGYAN 85 P E + + +++ GHV GKST++ I G R +L + Sbjct: 165 VPEIFEQSNPKPVVHLVVTGHVDSGKSTMLGRIMFELGEINSRSMQKLHNEAANSGKGSF 224 Query: 86 AKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATM 145 + + LD R +ST E I D PGH ++ M Sbjct: 225 SYAWLLDTTEEERARGVTMDVASTTFESDKKI------------YEIGDAPGHRDFISGM 272 Query: 146 LNGAAVMDAALLLIAGNES------CPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQ 199 + GA+ D A+L++ +++ QT EH + + + I++ NK+DL+ S Sbjct: 273 IAGASSADFAVLVVDSSQNNFERGFLENGQTREHAYLLRALGISEIVVSVNKLDLM--SW 330 Query: 200 AKEQYEQILAFVQ-------GTVAEGAPIIPISAQL--------------KYNIEVVCEY 238 +++++++I V G +PISA Y + Sbjct: 331 SEDRFQEIKNIVSDFLIKMVGFKTSNVHFVPISAISGTNLIQKDSSDLYKWYKGPTLLSA 390 Query: 239 IVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRP 298 + + +P P + + RL + + + G + G ++V Q + Sbjct: 391 LDQLVP-PEKPYRKPLRLSIDDVY---------RSPRSVTVTGRVEAGNVQVNQVLYDVS 440 Query: 299 GIVSKDSEGKLMCKP------IFSKIVSLFAEHNDLQYAAPGGLI 337 + + + V+L ++ PG ++ Sbjct: 441 SQEDAYVKNVIRNSDPSSTWAVAGDTVTLQLADIEVNQLRPGDIL 485 >3J4J-A nrPDB Length = 569 Score = 151 bits (380), Expect = 8e-37, Method: Composition-based stats. Identities = 67/305 (21%), Positives = 119/305 (39%), Gaps = 68/305 (22%) Query: 38 RQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCP 97 R+ + + +GHV HGK+T++ + R + IT +G K Sbjct: 71 RRPPV-VVIMGHVDHGKTTLLDYLRK---SRIAEKEAGGITQHVGAFEVK---------- 116 Query: 98 RPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALL 157 V F+D PGH+ GA V D A++ Sbjct: 117 ---------------------------TPQGTVVFIDTPGHEAFTTIRQRGAKVADIAVI 149 Query: 158 LIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAK-EQYEQILAFVQGTVA 216 +IA ++ PQT E +A + K ++ NKIDL + K ++ FV Sbjct: 150 VIAADDGI-MPQTEEAIAHAKAAGAK-LIFAINKIDLPQADPEKVKRQLMERGFVPEEYG 207 Query: 217 EGAPIIPISAQLKYNIEVVCEYI--VKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDL 274 A +IPISA+ ++ + E I + ++ D +EPR +++ S ++D Sbjct: 208 GDAIVIPISAKTGQGVQDLLEMILLLAELEDYRADPNAEPRGVILES--------KLDKQ 259 Query: 275 KGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPG 334 G +A + +G +VG + V+ ++ G++ + A+ N + A PG Sbjct: 260 AGIIANMLVQEGTFRVGDYV------VAGEAYGRIRA--------MMDADGNQRKEAGPG 305 Query: 335 GLIGV 339 + V Sbjct: 306 SAVQV 310 >4KJZ-A nrPDB Length = 473 Score = 150 bits (379), Expect = 1e-36, Method: Composition-based stats. Identities = 67/305 (21%), Positives = 119/305 (39%), Gaps = 68/305 (22%) Query: 38 RQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCP 97 R+ + + +GHV HGK+T++ + R + IT +G K Sbjct: 70 RRPPV-VVIMGHVDHGKTTLLDYLRK---SRIAEKEAGGITQHVGAFEVK---------- 115 Query: 98 RPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALL 157 V F+D PGH+ GA V D A++ Sbjct: 116 ---------------------------TPQGTVVFIDTPGHEAFTTIRQRGAKVADIAVI 148 Query: 158 LIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAK-EQYEQILAFVQGTVA 216 +IA ++ PQT E +A + K ++ NKIDL + K ++ FV Sbjct: 149 VIAADDGI-MPQTEEAIAHAKAAGAK-LIFAINKIDLPQADPEKVKRQLMERGFVPEEYG 206 Query: 217 EGAPIIPISAQLKYNIEVVCEYI--VKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDL 274 A +IPISA+ ++ + E I + ++ D +EPR +++ S ++D Sbjct: 207 GDAIVIPISAKTGQGVQDLLEMILLLAELEDYRADPNAEPRGVILES--------KLDKQ 258 Query: 275 KGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPG 334 G +A + +G +VG + V+ ++ G++ + A+ N + A PG Sbjct: 259 AGIIANMLVQEGTFRVGDYV------VAGEAYGRIRA--------MMDADGNQRKEAGPG 304 Query: 335 GLIGV 339 + V Sbjct: 305 SAVQV 309 >4B44-A nrPDB Length = 363 Score = 148 bits (374), Expect = 4e-36, Method: Composition-based stats. Identities = 67/305 (21%), Positives = 120/305 (39%), Gaps = 68/305 (22%) Query: 38 RQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCP 97 R+ + + +GHV HGK+T++ + R + IT +G K Sbjct: 71 RRPPV-VVIMGHVDHGKTTLLDYLRK---SRIAEKEAGGITQHVGAFEVK---------- 116 Query: 98 RPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALL 157 V F+D PGH+ GA V D A++ Sbjct: 117 ---------------------------TPQGTVVFIDTPGHEAFTTIRQRGAKVADIAVI 149 Query: 158 LIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQI-LAFVQGTVA 216 +IA ++ PQT E +A + K ++ NKIDL + K + + + FV Sbjct: 150 VIAADDGI-MPQTEEAIAHAKAAGAK-LIFAINKIDLPQADPEKVKRQLMERGFVPEEYG 207 Query: 217 EGAPIIPISAQLKYNIEVVCEYI--VKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDL 274 A +IPISA+ ++ + E I + ++ D +EPR +++ S ++D Sbjct: 208 GDAIVIPISAKTGQGVQDLLEMILLLAELEDYRADPNAEPRGVILES--------KLDKQ 259 Query: 275 KGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPG 334 G +A + +G +VG + V+ ++ G++ + A+ N + A PG Sbjct: 260 AGIIANMLVQEGTFRVGDYV------VAGEAYGRIRA--------MMDADGNQRKEAGPG 305 Query: 335 GLIGV 339 + V Sbjct: 306 SAVQV 310 >4CRN-P nrPDB Length = 430 Score = 147 bits (370), Expect = 1e-35, Method: Composition-based stats. Identities = 67/438 (15%), Positives = 141/438 (32%), Gaps = 82/438 (18%) Query: 37 SRQATINIGTIGHVAHGKSTVVK---AISGVHTVRFKNELERNITIKLGYANAKIYKLDD 93 + +++ +GHV GKST+ ++G R + ER + +D Sbjct: 1 GGKDHVSLIFMGHVDAGKSTMGGNLLYLTGSVDKRTIEKYEREAKDAGRQGWYLSWVMDT 60 Query: 94 PSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMD 153 R ++ T G R + +D PGH + ++ M+ GA+ D Sbjct: 61 NKEER------------NDGKTIEVGKAYFETEKRRYTILDAPGHKMYVSEMIGGASQAD 108 Query: 154 AALLLIAGNESCPQP------QTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQI 207 +L+I+ + + QT EH + + ++++ NK+D + +KE+Y+Q Sbjct: 109 VGVLVISARKGEYETGFERGGQTREHALLAKTQGVNKMVVVVNKMDDPTVNWSKERYDQC 168 Query: 208 LAFVQGT-------VAEGAPIIPISAQLKYN--------------IEVVCEYIVKKIPVP 246 ++ V + +P+S N + EY+ + Sbjct: 169 VSNVSNFLRAIGYNIKTDVVFMPVSGYSGANLKDHVDPKECPWYTGPTLLEYLD-TMNHV 227 Query: 247 PRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSE 306 R + L + G + G I G +K GQ + P + + + Sbjct: 228 DRHINAPFMLPI----------AAKMKDLGTIVEGKIESGHIKKGQSTLLMPNKTAVEIQ 277 Query: 307 GKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPE 366 N++ A G + + K + D G VL + + Sbjct: 278 NIYNETE------------NEVDMAMCGEQVKLRIK---GVEEEDISPGFVLTSPKNPIK 322 Query: 367 IFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIG--SLSTGGRVSAVKADL 424 T+ ++ + + + V+ V+ + + ++ Sbjct: 323 SVTKFVAQIAIV------------ELKSIIAAGFSCVMHVHTAIEEVHIVKLLHKLEKGT 370 Query: 425 GKIVLTNPVCTEVGEKIA 442 + P + G K+ Sbjct: 371 NRKSKKPPAFAKKGMKVI 388 >3IZQ-1 nrPDB Length = 611 Score = 146 bits (368), Expect = 2e-35, Method: Composition-based stats. Identities = 52/359 (14%), Positives = 121/359 (33%), Gaps = 64/359 (17%) Query: 40 ATINIGTIGHVAHGKSTVVKAISG---VHTVRFKNELERNITIKLGYANAKI-YKLDDPS 95 ++ +GHV GKST++ + + +L+R + +G ++ K + +D + Sbjct: 166 PHLSFVVLGHVDAGKSTLMGRLLYDLNIVNQSQLRKLQRE-SETMGKSSFKFAWIMDQTN 224 Query: 96 CPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAA 155 R ++ + + VD PGH + + G + D A Sbjct: 225 EERERGVTVSICTSH------------FSTHRANFTIVDAPGHRDFVPNAIMGISQADMA 272 Query: 156 LLLIAGNESCPQ------PQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILA 209 +L + + + + QT EH+ + + +++I NK+D V +++++E+I + Sbjct: 273 ILCVDCSTNAFESGFDLDGQTKEHMLLASSLGIHNLIIAMNKMDNVD--WSQQRFEEIKS 330 Query: 210 FVQ------GTVAEGAPIIPISA---------------QLKYNIEVVCEYIVKKIPVPPR 248 + G + +PIS + YN + + + Sbjct: 331 KLLPYLVDIGFFEDNINWVPISGFSGEGVYKIEYTDEVRQWYNGPNLMSTLENAAFKISK 390 Query: 249 DF-----TSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSK 303 + V+ K ++ + G + G ++ G+ + + P Sbjct: 391 ENEGINKDDPFLFSVLEIIPSKKTSNDL-----ALVSGKLESGSIQPGESLTIYPS---- 441 Query: 304 DSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVG 362 + ++ K H + A G + + + D G + +V Sbjct: 442 -EQSCIVDKIQVGSQQGQSTNHEETDVAIKGDFVTLKLR---KAYPEDIQNGDLAASVD 496 >3P27-A nrPDB Length = 483 Score = 145 bits (365), Expect = 4e-35, Method: Composition-based stats. Identities = 52/359 (14%), Positives = 121/359 (33%), Gaps = 64/359 (17%) Query: 40 ATINIGTIGHVAHGKSTVVKAISG---VHTVRFKNELERNITIKLGYANAKI-YKLDDPS 95 ++ +GHV GKST++ + + +L+R + +G ++ K + +D + Sbjct: 32 PHLSFVVLGHVDAGKSTLMGRLLYDLNIVNQSQLRKLQRE-SETMGKSSFKFAWIMDQTN 90 Query: 96 CPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAA 155 R ++ + + VD PGH + + G + D A Sbjct: 91 EERERGVTVSICTSH------------FSTHRANFTIVDAPGHRDFVPNAIMGISQADMA 138 Query: 156 LLLIAGNESCPQ------PQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILA 209 +L + + + + QT EH+ + + +++I NK+D V +++++E+I + Sbjct: 139 ILCVDCSTNAFESGFDLDGQTKEHMLLASSLGIHNLIIAMNKMDNVD--WSQQRFEEIKS 196 Query: 210 FVQ------GTVAEGAPIIPISA---------------QLKYNIEVVCEYIVKKIPVPPR 248 + G + +PIS + YN + + + Sbjct: 197 KLLPYLVDIGFFEDNINWVPISGFSGEGVYKIEYTDEVRQWYNGPNLMSTLENAAFKISK 256 Query: 249 DF-----TSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSK 303 + V+ K ++ + G + G ++ G+ + + P Sbjct: 257 ENEGINKDDPFLFSVLEIIPSKKTSNDL-----ALVSGKLESGSIQPGESLTIYPS---- 307 Query: 304 DSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVG 362 + ++ K H + A G + + + D G + +V Sbjct: 308 -EQSCIVDKIQVGSQQGQSTNHEETDVAIKGDFVTLKLR---KAYPEDIQNGDLAASVD 362 >5IMR-C nrPDB Length = 610 Score = 136 bits (342), Expect = 2e-32, Method: Composition-based stats. Identities = 61/324 (18%), Positives = 104/324 (32%), Gaps = 46/324 (14%) Query: 43 NIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECY 102 N I HV HGKST+ I + E+ LD R Sbjct: 11 NFSIIAHVDHGKSTLADRILELTHAVSDREMREQ-------------FLDSLELERERGI 57 Query: 103 RSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGN 162 S+ + +D PGH + A ++ LL++ + Sbjct: 58 TIKASAVRVTYRAKDGEEYV-------FHLIDTPGHVDFTYEVSRALAAVEGVLLVVDAS 110 Query: 163 ESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPII 222 + ++ A+E + I+ + NKIDL + E + V G A+ A I Sbjct: 111 QGVEAETLAKFYMALEHGHV--IIPVINKIDLPNARPLEVALE--VEEVLGLPADEA--I 164 Query: 223 PISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGS 282 S + +E + E IV++IP P D + + ++ S D +G + Sbjct: 165 FASGKTGEGVEEILEAIVQRIPPPKGDPEAPLKALIFDSV--------YDAYQGVIPYLR 216 Query: 283 ILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTK 342 + +G ++ G I + S GK K+ + A G +G Sbjct: 217 LFEGRVRPGDRIRI-------YSTGKEF---TVDKVGVFTPQGLVATEALEAGEVGWLVA 266 Query: 343 IDPTLCRADRMVGQVLGAVGALPE 366 + D VG + Sbjct: 267 AIRDIH--DVQVGDTITLADRPTP 288 >5J8B-z nrPDB Length = 679 Score = 136 bits (342), Expect = 2e-32, Method: Composition-based stats. Identities = 61/324 (18%), Positives = 104/324 (32%), Gaps = 46/324 (14%) Query: 43 NIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECY 102 N I HV HGKST+ I + E+ LD R Sbjct: 80 NFSIIAHVDHGKSTLADRILELTHAVSDREMREQ-------------FLDSLELERERGI 126 Query: 103 RSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGN 162 S+ + +D PGH + A ++ LL++ + Sbjct: 127 TIKASAVRVTYRAKDGEEYV-------FHLIDTPGHVDFTYEVSRALAAVEGVLLVVDAS 179 Query: 163 ESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPII 222 + ++ A+E + I+ + NKIDL + E + V G A+ A I Sbjct: 180 QGVEAETLAKFYMALEHGHV--IIPVINKIDLPNARPLEVALE--VEEVLGLPADEA--I 233 Query: 223 PISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGS 282 S + +E + E IV++IP P D + + ++ S D +G + Sbjct: 234 FASGKTGEGVEEILEAIVQRIPPPKGDPEAPLKALIFDSV--------YDAYQGVIPYLR 285 Query: 283 ILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTK 342 + +G ++ G I + S GK K+ + A G +G Sbjct: 286 LFEGRVRPGDRIRI-------YSTGKEF---TVDKVGVFTPQGLVATEALEAGEVGWLVA 335 Query: 343 IDPTLCRADRMVGQVLGAVGALPE 366 + D VG + Sbjct: 336 AIRDIH--DVQVGDTITLADRPTP 357 >3CB4-D nrPDB Length = 599 Score = 122 bits (305), Expect = 4e-28, Method: Composition-based stats. Identities = 54/257 (21%), Positives = 95/257 (36%), Gaps = 38/257 (14%) Query: 43 NIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECY 102 N I H+ HGKST+ I + E+E + LD R Sbjct: 6 NFSIIAHIDHGKSTLSDRIIQICGGLSDREMEAQV-------------LDSMDLERERGI 52 Query: 103 RSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGN 162 S ++ T ++F+D PGH + A + ALL++ Sbjct: 53 TIKAQSVTLDYKASDGETY-------QLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAG 105 Query: 163 ESCPQPQTSEHLAAIEIMKLKHILILQNKIDLV--KESQAKEQYEQILAFVQGTVAEGAP 220 + + A+E+ ++ + NKIDL + E+ E I+ + Sbjct: 106 QGVEAQTLANCYTAMEM--DLEVVPVLNKIDLPAADPERVAEEIEDIVGI------DATD 157 Query: 221 IIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAG 280 + SA+ ++ V E +V+ IP P D + ++I S+ D+ G V+ Sbjct: 158 AVRCSAKTGVGVQDVLERLVRDIPPPEGDPEGPLQALIIDSW--------FDNYLGVVSL 209 Query: 281 GSILKGVLKVGQEIEVR 297 I G L+ G +++V Sbjct: 210 IRIKNGTLRKGDKVKVM 226 >5I4Q-C nrPDB Length = 217 Score = 119 bits (297), Expect = 3e-27, Method: Composition-based stats. Identities = 49/242 (20%), Positives = 88/242 (36%), Gaps = 31/242 (12%) Query: 222 IPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGG 281 + A+ + I + ++ IP P R L + F ++ +G V G Sbjct: 2 LEGDAEWEAKILELAGFLDSYIPEPERAIDKPFLLPIEDVFSISG--------RGTVVTG 53 Query: 282 SILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGT 341 + +G++KVG+E+E+ V K C + L G +GV Sbjct: 54 RVERGIIKVGEEVEI----VGIKETQKSTCTGV-------EMFRKLLDEGRAGENVGVLL 102 Query: 342 KIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKN 401 + + R + GQVL G + + T+ E ++L + G R K + Sbjct: 103 R---GIKREEIERGQVLAKPGTI-KPHTKFESEVYILSKDEGGRHTPFFKG--YRPQFYF 156 Query: 402 EVLMVNIGSLSTGGRVSAVKADLGKIVLTN--PVCTEVGEKIALSRRVEKHWRLIGWGQI 459 V G + D K+V+T P+ + G + A+ R R +G G + Sbjct: 157 RTTDVTGTIELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAI--REGG--RTVGAGVV 212 Query: 460 RR 461 + Sbjct: 213 AK 214 >5A9Z-CA nrPDB Length = 593 Score = 114 bits (286), Expect = 6e-26, Method: Composition-based stats. Identities = 56/303 (18%), Positives = 100/303 (33%), Gaps = 37/303 (12%) Query: 43 NIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECY 102 NI I HV HGK+T+V + A + +D + Sbjct: 7 NIAIIAHVDHGKTTLVDKLLQQSGTFDSR------------AETQERVMDSNDLEKERGI 54 Query: 103 RSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGN 162 +T K ++ VD PGH + +++D+ LL++ Sbjct: 55 TILAKNTAA------------IKWDYRINIVDTPGHADFGGEVERVMSMVDSVLLVVDAF 102 Query: 163 ESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVK--ESQAKEQYEQILAFVQGTVAE-GA 219 + P PQT LK I++ NK+D +Q + + T + Sbjct: 103 DG-PMPQTRFVTKKAFAYGLKPIVV-INKVDRPGARPDWVVDQVFDLFVNLDATDEQLDF 160 Query: 220 PIIPISAQLKYNIEVVCEYIVKKIPVPPR--DFTSEPRLIVIRSFDVNKPGCEVDDLKGG 277 I+ SA + P+ D P + + F + + + G Sbjct: 161 AIVYASALNGIAGLDHEDMAEDMTPLYQAIVDHVPAPDVDLDGPFQMQISQLDYNSYVGV 220 Query: 278 VAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLI 337 + G I +G +K Q++ + DSEGK + + L E + A G ++ Sbjct: 221 IGIGRIKRGKVKPNQQVTI------IDSEGKTRNAKVGKVLGHLGLERIETDLAEAGDIV 274 Query: 338 GVG 340 + Sbjct: 275 AIT 277 >1G7S-A nrPDB Length = 594 Score = 113 bits (281), Expect = 3e-25, Method: Composition-based stats. Identities = 69/399 (17%), Positives = 124/399 (31%), Gaps = 78/399 (19%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYR 103 + +GHV HGK+T++ I G IT +G P Sbjct: 8 VSVLGHVDHGKTTLLDHIRGSAVAS---REAGGITQHIGATEI----------PMDVIEG 54 Query: 104 SCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNE 163 CG D + + + F+D PGH+ G A+ D A+L++ NE Sbjct: 55 ICG---------DFLKKFSIRETLPGLFFIDTPGHEAFTTLRKRGGALADLAILIVDINE 105 Query: 164 SCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKE--------------------- 202 +PQT E L + + + ++ NKID + + E Sbjct: 106 GF-KPQTQEALNILRMYRTPF-VVAANKIDRIHGWRVHEGRPFMETFSKQDIQVQQKLDT 163 Query: 203 QYEQILAFVQGTVAEG------------APIIPISAQLKYNIEVVCEYIVKKIPVPPRDF 250 + +++ + E IIPISA I + ++ R+ Sbjct: 164 KVYELVGKLHEEGFESERFDRVTDFASQVSIIPISAITGEGIPELLTMLMGLAQQYLREQ 223 Query: 251 -----TSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDS 305 S R ++ + G +D + I G+L+ I + + Sbjct: 224 LKIEEDSPARGTILEVKEETGLGMTIDAV--------IYDGILRKDDTIAMMTSKDVIST 275 Query: 306 EGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALP 365 + + KP + + Q + P + D M G L V Sbjct: 276 RIRSLLKP--RPLEEMRESRKKFQKVDEVVAAAGIKIVAPGI--DDVMAGSPLRVVTDPE 331 Query: 366 EIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVL 404 ++ E+ ++ + T+ K L E + Sbjct: 332 KVREEILSEIEDIK----IDTDEAGVVVKADTLGSLEAV 366 >5FG3-A nrPDB Length = 623 Score = 108 bits (270), Expect = 4e-24, Method: Composition-based stats. Identities = 70/399 (17%), Positives = 125/399 (31%), Gaps = 76/399 (19%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYR 103 + +GHV HGK+T++ I + IT +G + ++ + P + Sbjct: 19 VVVLGHVDHGKTTLLDKIRRTAVAA---KEAGGITQHIGASIVPADVIEKIAEPLKKVIP 75 Query: 104 SCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNE 163 + + F+D PGH++ G +V D A+L++ E Sbjct: 76 VKLV-------------------IPGLLFIDTPGHELFSNLRRRGGSVADFAILVVDIME 116 Query: 164 SCPQPQTSEHLAAIEIMKLKHILILQNKIDLV------------------KESQAKEQYE 205 +PQT E L ++ ++ ++ NKID + + + Sbjct: 117 GF-KPQTYEALELLKERRVPFLIAA-NKIDRIPGWKPNPDAPFIETIRRQDPKVREILEQ 174 Query: 206 QILAFVQGTVAEGAP---------------IIPISAQLKYNIEVVCEYI----VKKIPVP 246 ++ V G P I+P+SA+ I + + + Sbjct: 175 RVYEIVGKMYEAGLPAELFTRIKDFRRKIAIVPVSARTGEGIPELLAVLAGLTQTYLKER 234 Query: 247 PRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSE 306 R + +V+ ++ G V I GVLK I V + Sbjct: 235 LRYAEGPAKGVVLEVKEMQGF--------GTVVDAVIYDGVLKKEDIIVVGGREGPIVTR 286 Query: 307 GKLMCKPI-FSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALP 365 + + P I S A + + + P L D + G + A + Sbjct: 287 VRALLMPAPLQDIRSREARFVQVDRVYAAAGVRIAA---PGL--DDVIAGSPIYAAESEE 341 Query: 366 EIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVL 404 E +E + L RTE K L E L Sbjct: 342 EARKLMEAVQREIE-ELRFRTENIGVVVKADTLGTLEAL 379 >6GB2-BC nrPDB Length = 657 Score = 107 bits (266), Expect = 1e-23, Method: Composition-based stats. Identities = 62/363 (17%), Positives = 113/363 (31%), Gaps = 80/363 (22%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYR 103 + +GHV HGK+T++ + IT +G Sbjct: 113 VTIMGHVDHGKTTLLDKFRKTQVAAVETG---GITQHIG--------------------- 148 Query: 104 SCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNE 163 + ++F+D PGH A GA V D +L++A ++ Sbjct: 149 ---------------AFLVSLPSGEKITFLDTPGHAAFSAMRARGAQVTDIVVLVVAADD 193 Query: 164 SCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQIL-AFVQGTVAEGAPII 222 QT E + + ++ I++ NK D + K + E + V + Sbjct: 194 GV-MKQTVESIQHAKDAQVP-IILAVNKCDKAEADPEKVKKELLAYDVVCEDYGGDVQAV 251 Query: 223 PISAQLKYNIEVVCEYIVKKIP--VPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAG 280 P+SA N+ + E V D VI SF +G V Sbjct: 252 PVSALTGDNLMALAEATVALAEMLELKADPNGPVEGTVIESFTDKG--------RGLVTT 303 Query: 281 GSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHND-LQYAAPGGLIGV 339 I +G L+ G + ++K+ +F E+ + A P +G+ Sbjct: 304 AIIQRGTLRKGSVLV---------------AGKCWAKVRLMFDENGKTIDEAYPSMPVGI 348 Query: 340 GTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLS 399 D + + E+ +E + R E ++ K+ + Sbjct: 349 TGWRDLPSAGEEIL------------EVESEPRAREVVDWRKYEQEQEKGQEDLKIIEEK 396 Query: 400 KNE 402 + E Sbjct: 397 RKE 399 >2LKD-A nrPDB Length = 178 Score = 105 bits (261), Expect = 5e-23, Method: Composition-based stats. Identities = 41/210 (19%), Positives = 79/210 (37%), Gaps = 45/210 (21%) Query: 32 SHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKL 91 ++ R + I +GHV HGK+T++ AI + + IT +G Sbjct: 1 GSHMVERPPVVTI--MGHVDHGKTTLLDAIRH---SKVTEQEAGGITQHIG--------- 46 Query: 92 DDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAV 151 Y+ + + ++F+D PGH+ GA V Sbjct: 47 ---------AYQVTVND-------------------KKITFLDTPGHEAFTTMRARGAQV 78 Query: 152 MDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQIL-AF 210 D +L++A ++ PQT E + + + I++ NK+D + + + E + Sbjct: 79 TDIVILVVAADDGV-MPQTVEAINHAKAANVP-IIVAINKMDKPEANPDRVMQELMEYNL 136 Query: 211 VQGTVAEGAPIIPISAQLKYNIEVVCEYIV 240 V +SA+ K ++ + E I+ Sbjct: 137 VPEEWGGDTIFCKLSAKTKEGLDHLLEMIL 166 >5YT0-A nrPDB Length = 364 Score = 104 bits (260), Expect = 6e-23, Method: Composition-based stats. Identities = 60/335 (17%), Positives = 108/335 (32%), Gaps = 72/335 (21%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYR 103 + +GHV HGK+T++ I + IT +G + ++ + P + Sbjct: 19 VVVLGHVDHGKTTLLDKIRRTAVAA---KEAGGITQHIGASIVPADVIEKIAEPLKKVIP 75 Query: 104 SCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNE 163 + + F+D PGH++ G +V D A+L++ E Sbjct: 76 VKLV-------------------IPGLLFIDTPGHELFSNLRRRGGSVADFAILVVDIME 116 Query: 164 SCPQPQTSEHLAAIEIMKLKHILILQNKIDLV------------------KESQAKEQYE 205 +PQT E L ++ ++ ++ NKID + + + Sbjct: 117 GF-KPQTYEALELLKERRVPFLIAA-NKIDRIPGWKPNPDAPFIETIRRQDPKVREILEQ 174 Query: 206 QILAFVQGTVAEGAP---------------IIPISAQLKYNIEVVCEYI----VKKIPVP 246 ++ V G P I+P+SA+ I + + + Sbjct: 175 RVYEIVGKMYEAGLPAELFTRIKDFRRKIAIVPVSARTGEGIPELLAVLAGLTQTYLKER 234 Query: 247 PRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSE 306 R + +V+ ++ G V I GVLK I V + Sbjct: 235 LRYAEGPAKGVVLEVKEMQGF--------GTVVDAVIYDGVLKKEDIIVVGGREGPIVTR 286 Query: 307 GKLMCKPI-FSKIVSLFAEHNDLQ--YAAPGGLIG 338 + + P I S A + YAA G I Sbjct: 287 VRALLMPAPLQDIRSREARFVQVDRVYAAAGVRIA 321 >5KCS-1w nrPDB Length = 639 Score = 104 bits (258), Expect = 9e-23, Method: Composition-based stats. Identities = 38/174 (21%), Positives = 64/174 (36%), Gaps = 25/174 (14%) Query: 42 INIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPEC 101 INIG + HV GK+T+ +++ +LG + + D+ R Sbjct: 4 INIGVLAHVDAGKTTLTESLLY----------NSGAITELGSVDKGTTRTDNTLLERQRG 53 Query: 102 YRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAG 161 T ++ V+ +D PGH +A + +V+D A+LLI+ Sbjct: 54 ITIQTGITSFQWENT------------KVNIIDTPGHMDFLAEVYRSLSVLDGAILLISA 101 Query: 162 NESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTV 215 + Q QT A+ M + I NKID Y+ I + + Sbjct: 102 KDGV-QAQTRILFHALRKMGIPTIF-FINKIDQNGID-LSTVYQDIKEKLSAEI 152 >4V6V-A1 nrPDB Length = 639 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 38/174 (21%), Positives = 69/174 (39%), Gaps = 25/174 (14%) Query: 42 INIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPEC 101 IN+G + HV GK+T+ +++ +LG + + D + R Sbjct: 4 INLGILAHVDAGKTTLTESLLYTS----------GAIAELGSVDEGTTRTDTMNLERQRG 53 Query: 102 YRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAG 161 + T ++ V+ +D PGH +A + +V+D A+LL++ Sbjct: 54 ITIQTAVTSFQWEDV------------KVNIIDTPGHMDFLAEVYRSLSVLDGAVLLVSA 101 Query: 162 NESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTV 215 + Q QT A++IMK+ I NKID Y ++ A + + Sbjct: 102 KDGI-QAQTRILFHALQIMKIPTIF-FINKIDQEGID-LPMVYREMKAKLSSEI 152 >3IZY-P nrPDB Length = 537 Score = 99 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 63/363 (17%), Positives = 114/363 (31%), Gaps = 80/363 (22%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYR 103 + +GHV HGK+T++ + + IT +G Sbjct: 7 VTIMGHVDHGKTTLLDKLRKTQVAAME---AGGITQHIG--------------------- 42 Query: 104 SCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNE 163 + ++F+D PGH A G V D +L++A ++ Sbjct: 43 ---------------AFLVSLPSGEKITFLDTPGHAAFSAMRARGTQVTDIVILVVAADD 87 Query: 164 SCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQIL-AFVQGTVAEGAPII 222 QT E + + + I++ NK D + K + E + V + Sbjct: 88 GV-MKQTVESIQHAKDAHVP-IVLAINKCDKAEADPEKVKKELLAYDVVCEDYGGDVQAV 145 Query: 223 PISAQLKYNIEVVCEYIVKKIP--VPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAG 280 +SA N+ + E + D T VI SF +G V Sbjct: 146 HVSALTGENMMALAEATIALAEMLELKADPTGAVEGTVIESFTDKG--------RGPVTT 197 Query: 281 GSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIG-V 339 I +G L+ G +V+ S K+ + + A P +G + Sbjct: 198 AIIQRGTLRKG------SILVAGKSWAKVR--------LMFDENGRAVNEAYPSMPVGII 243 Query: 340 GTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLS 399 G + P+ A + E+ +E + R E +K+ K+ + Sbjct: 244 GWRDLPS-------------AGDEILEVESEPRAREVVDWRKYEQEQEKNKEDLKLIEEK 290 Query: 400 KNE 402 + E Sbjct: 291 RKE 293 >4NCL-A nrPDB Length = 457 Score = 99.6 bits (246), Expect = 3e-21, Method: Composition-based stats. Identities = 55/345 (15%), Positives = 109/345 (31%), Gaps = 73/345 (21%) Query: 45 GTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYRS 104 +GHV GK+ ++ I + + IT ++G + Sbjct: 14 CILGHVDTGKTKLLDKIRQTNV---QEGEAGGITQQIGATYFPV---------------- 54 Query: 105 CGSSTPDEFPTDIPGTKGNFKLV-RHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNE 163 + T + G F+ + +D PGH+ G+++ + A+L++ Sbjct: 55 ----EAIKQKTAVVNKDGKFEFKVPGLLIIDTPGHESFSNLRSRGSSLCNIAILVVDIMH 110 Query: 164 SCPQPQTSEHLAAIEIMKLKHILILQNKIDL----------------------------- 194 PQT E L + K ++ NKID Sbjct: 111 GLE-PQTIESLRLLRERKTPF-VVALNKIDRLYGWKKIENNGFRESFALQNKAVQNEFRN 168 Query: 195 ----VKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRD- 249 VK A++ + L + A ++P SA I + + IV+ Sbjct: 169 RLDQVKLQFAEQGFNSELFYENKNFARYVSLVPTSAHTGEGIPDMLKLIVQLCQERMASS 228 Query: 250 --FTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEG 307 + SE + V+ + G +D + + G+L+ G I + + Sbjct: 229 LMYLSELQATVLEVKAIEGFGVTIDVI--------LSNGILREGDRIVLCGLEGPIKTNI 280 Query: 308 KLMCKPIFS---KIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCR 349 + + P +I + H +++ A + G + R Sbjct: 281 RALLTPAPMRELRIKGQYIHHKEVKAAQGVKISAPGLEGAIAGSR 325 >4N3G-A nrPDB Length = 603 Score = 98.0 bits (242), Expect = 7e-21, Method: Composition-based stats. Identities = 55/345 (15%), Positives = 110/345 (31%), Gaps = 73/345 (21%) Query: 45 GTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYRS 104 +GHV GK+ ++ I + + IT ++G + Sbjct: 14 CILGHVDTGKTKLLDKIRQTNV---QEGEAGGITQQIGATYFPV---------------- 54 Query: 105 CGSSTPDEFPTDIPGTKGNFKLV-RHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNE 163 + T + G F+ + +D PGH+ G+++ + A+L++ Sbjct: 55 ----EAIKQKTAVVNKDGKFEFKVPGLLIIDTPGHESFSNLRSRGSSLCNIAILVVDIMH 110 Query: 164 SCPQPQTSEHLAAIEIMKLKHILILQNKIDL----------------------------- 194 +PQT E L + K ++ NKID Sbjct: 111 GL-EPQTIESLRLLRERKTPF-VVALNKIDRLYGWKKIENNGFRESFALQNKAVQNEFRN 168 Query: 195 ----VKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRD- 249 VK A++ + L + A ++P SA I + + IV+ Sbjct: 169 RLDQVKLQFAEQGFNSELFYENKNFARYVSLVPTSAHTGEGIPDMLKLIVQLCQERMASS 228 Query: 250 --FTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEG 307 + SE + V+ + G +D + + G+L+ G I + + Sbjct: 229 LMYLSELQATVLEVKAIEGFGVTIDVI--------LSNGILREGDRIVLCGLEGPIKTNI 280 Query: 308 KLMCKPIFS---KIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCR 349 + + P +I + H +++ A + G + R Sbjct: 281 RALLTPAPMRELRIKGQYIHHKEVKAAQGVKISAPGLEGAIAGSR 325 >1ZO1-I nrPDB Length = 501 Score = 94.6 bits (233), Expect = 8e-20, Method: Composition-based stats. Identities = 44/254 (17%), Positives = 85/254 (33%), Gaps = 53/254 (20%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYR 103 + +GHV HGK+++++ I Sbjct: 7 VTIMGHVDHGKTSLLEYIRSTKV----------------------------------ASG 32 Query: 104 SCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNE 163 G T + G ++F+D PGH + GA D +L++A ++ Sbjct: 33 EAGGITQHIGAYHVETENGM------ITFLDTPGHAAFTSMRARGAQATDIVVLVVAADD 86 Query: 164 SCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAK-EQYEQILAFVQGTVAEGAPII 222 PQT E + + +++ NKID + + + + + + Sbjct: 87 GV-MPQTIEAIQHAKAA-QVPVVVAVNKIDKPEADPDRVKNELSQYGILPEEWGGESQFV 144 Query: 223 PISAQLKYNIEVVCEYIVKKIPVPPRDFTSE--PRLIVIRSFDVNKPGCEVDDLKGGVAG 280 +SA+ I+ + + I+ + V + VI SF +D +G VA Sbjct: 145 HVSAKAGTGIDELLDAILLQAEVLELKAVRKGMASGAVIESF--------LDKGRGPVAT 196 Query: 281 GSILKGVLKVGQEI 294 + +G L G + Sbjct: 197 VLVREGTLHKGDIV 210 >4TN1-B nrPDB Length = 345 Score = 94.2 bits (232), Expect = 1e-19, Method: Composition-based stats. Identities = 55/345 (15%), Positives = 110/345 (31%), Gaps = 73/345 (21%) Query: 45 GTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYRS 104 +GHV GK+ ++ I + + IT ++G + Sbjct: 14 CILGHVRTGKTKLLDKIRQTNV---QEGEAGGITQQIGATYFPV---------------- 54 Query: 105 CGSSTPDEFPTDIPGTKGNFKLV-RHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNE 163 + T + G F+ + +D PGH+ G+++ + A+L++ Sbjct: 55 ----EAIKQKTAVVNKDGKFEFKVPGLLIIDTPGHESFSNLRSRGSSLCNIAILVVDIMH 110 Query: 164 SCPQPQTSEHLAAIEIMKLKHILILQNKIDL----------------------------- 194 +PQT E L + K ++ NKID Sbjct: 111 GL-EPQTIESLRLLRERKTPF-VVALNKIDRLYGWKKIENNGFRESFALQNKAVQNEFRN 168 Query: 195 ----VKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRD- 249 VK A++ + L + A ++P SA I + + IV+ Sbjct: 169 RLDQVKLQFAEQGFNSELFYENKNFARYVSLVPTSAHTGEGIPDMLKLIVQLCQERMASS 228 Query: 250 --FTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEG 307 + SE + V+ + G +D + + G+L+ G I + + Sbjct: 229 LMYLSELQATVLEVKAIEGFGVTIDVI--------LSNGILREGDRIVLCGLEGPIKTNI 280 Query: 308 KLMCKPIFS---KIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCR 349 + + P +I + H +++ A + G + R Sbjct: 281 RALLTPAPMRELRIKGQYIHHKEVKAAQGVKISAPGLEGAIAGSR 325 >3JCN-b nrPDB Length = 890 Score = 93.4 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 44/254 (17%), Positives = 85/254 (33%), Gaps = 53/254 (20%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYR 103 + +GHV HGK++++ I Sbjct: 394 VTIMGHVDHGKTSLLDYIRSTKV----------------------------------ASG 419 Query: 104 SCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNE 163 G T + G ++F+D PGH + GA D +L++A ++ Sbjct: 420 EAGGITQHIGAYHVETENGM------ITFLDTPGHAAFTSMRARGAQATDIVVLVVAADD 473 Query: 164 SCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAK-EQYEQILAFVQGTVAEGAPII 222 PQT E + + ++ ++ NKID + + + + + + Sbjct: 474 GV-MPQTIEAIQHAKAAQVPV-VVAVNKIDKPEADPDRVKNELSQYGILPEEWGGESQFV 531 Query: 223 PISAQLKYNIEVVCEYIVKKIPVPPRDFTSE--PRLIVIRSFDVNKPGCEVDDLKGGVAG 280 +SA+ I+ + + I+ + V + VI SF +D +G VA Sbjct: 532 HVSAKAGTGIDELLDAILLQAEVLELKAVRKGMASGAVIESF--------LDKGRGPVAT 583 Query: 281 GSILKGVLKVGQEI 294 + +G L G + Sbjct: 584 VLVREGTLHKGDIV 597 >4UJC-AB nrPDB Length = 627 Score = 91.1 bits (224), Expect = 1e-18, Method: Composition-based stats. Identities = 61/398 (15%), Positives = 126/398 (31%), Gaps = 72/398 (18%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYR 103 I +GHV GK+ ++ + R+ ++ G A ++ + P Sbjct: 41 ICVLGHVDTGKTKILDKL-------------RHTHVQDGEAGGITQQIGATNVPLEAINE 87 Query: 104 SCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNE 163 + + + +D PGH+ G+++ D A+L++ Sbjct: 88 QTKMIKNFDRENVR---------IPGMLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMH 138 Query: 164 SCPQPQTSEHLAAIEIMKLKHILILQNKIDLV------------------KESQAKEQYE 205 +PQT E + ++ K I + NKID + K++ E E Sbjct: 139 GL-EPQTIESINLLKSKKCPFI-VALNKIDRLYDWKKSPDSDVAATLKKQKKNTKDEFEE 196 Query: 206 QILAFVQGTVAEG---------------APIIPISAQLKYNIEVVCEYIVKKIPV---PP 247 + A + +G ++P SA + + +V+ Sbjct: 197 RAKAIIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVELTQTMLSKR 256 Query: 248 RDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEG 307 E R V+ + G +D + ++ G LK G I V ++ Sbjct: 257 LAHCEELRAQVMEVKALPGMGTTIDVI--------LINGRLKEGDTIIVPGVEGPIVTQI 308 Query: 308 KLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEI 367 + + P K + + ++ + + + K ++ V +P + Sbjct: 309 RGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLAGLPLL--VAYKEDEIPVL 366 Query: 368 FTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLM 405 EL L + L ++ E + L E L+ Sbjct: 367 KDELIHE--LKQTLNAIKLEEKGVYVQASTLGSLEALL 402 >4NCF-A nrPDB Length = 457 Score = 89.2 bits (219), Expect = 3e-18, Method: Composition-based stats. Identities = 49/323 (15%), Positives = 105/323 (32%), Gaps = 65/323 (20%) Query: 45 GTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYRS 104 +GHV GK+ ++ I R ++ G A ++ P Sbjct: 14 CILGHVDTGKTKLLDKI-------------RQTNVQGGEAGGITQQIGATYFPIDAIKAK 60 Query: 105 CGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNES 164 E T V + +D PGH+ G+++ + A+L+I Sbjct: 61 TKVMAEYEKQTFD---------VPGLLVIDTPGHESFSNLRSRGSSLCNIAILVIDIMHG 111 Query: 165 CPQPQTSEHLAAIEIMKLKHILILQNKIDLVKE---------------------SQAKEQ 203 Q QT E + + K ++ NKID + + + + + Sbjct: 112 LEQ-QTIESIKLLRDRKAPF-VVALNKIDRLYDWKAIPNNSFRDSFAKQSRAVQEEFQSR 169 Query: 204 YEQI------------LAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFT 251 Y +I L F +++ I+P SA + + +++ + + Sbjct: 170 YSKIQLELAEQGLNSELYFQNKNMSKYVSIVPTSAVTGEGVPDLLWLLLELT---QKRMS 226 Query: 252 SEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMC 311 + L+ + + +V + G + G L+ G I + + + + Sbjct: 227 KQ--LMYLSHVEATILEVKVVEGFGTTIDVILSNGYLREGDRIVLCGMNGPIVTNIRALL 284 Query: 312 KPI---FSKIVSLFAEHNDLQYA 331 P ++ S + H +++ A Sbjct: 285 TPQPLRELRLKSEYVHHKEVKAA 307 >3WNB-A nrPDB Length = 370 Score = 89.2 bits (219), Expect = 4e-18, Method: Composition-based stats. Identities = 63/363 (17%), Positives = 129/363 (35%), Gaps = 57/363 (15%) Query: 98 RPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALL 157 S ++ + + N K R++ FVD + + +++ + D A+L Sbjct: 30 EKSGRTSLAANLGKKGTSSDITMYNNDKEGRNMVFVDAHSYPKTLKSLITALNISDIAVL 89 Query: 158 LIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAE 217 I + T E + A++++ KH +I + D E ++ GTV + Sbjct: 90 CIPP-QGL-DAHTGECIIALDLLGFKHGIIALTRSDSTHMHAIDELKAKLKVITSGTVLQ 147 Query: 218 GAPII----PISAQLKY-NIEVV---CEYIVKKIPVPPRDFTSEP-RLIVIRSFDVNKPG 268 I SA+ + ++ + + +KI + S P R+ + +F+V Sbjct: 148 DWECISLNTNKSAKNPFEGVDELKARINEVAEKIEAENAELNSLPARIFIDHAFNVTG-- 205 Query: 269 CEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDL 328 KG V G + +G+ K + ++ P +I S+ + D+ Sbjct: 206 ------KGCVVLGVVKQGISKDKDKTKIFP-------------LDRDIEIRSIQSHDVDI 246 Query: 329 QYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEG 388 A G +G+ K + D G ++ + +T LE + + Sbjct: 247 DSAPAGTRVGMRLK---NVQAKDIERGFIISDKEIVTTDYT-LECTVSKFTK-------- 294 Query: 389 DKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNP-----VCTEVGEKIAL 443 K+ VL + +G S RV + D ++ P + +K+A Sbjct: 295 --------KIEPASVLHLFVGLQSEPVRVEKILVDGNEVEEAKPGSTCVLELSGNKKLAY 346 Query: 444 SRR 446 S++ Sbjct: 347 SKQ 349 >4V8Y-CP nrPDB Length = 339 Score = 88.4 bits (217), Expect = 6e-18, Method: Composition-based stats. Identities = 49/323 (15%), Positives = 105/323 (32%), Gaps = 65/323 (20%) Query: 45 GTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYRS 104 +GHV GK+ ++ I R ++ G A ++ P Sbjct: 9 CILGHVDTGKTKLLDKI-------------RQTNVQGGEAGGITQQIGATYFPIDAIKAK 55 Query: 105 CGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNES 164 E T V + +D PGH+ G+++ + A+L+I Sbjct: 56 TKVMAEYEKQTFD---------VPGLLVIDTPGHESFSNLRSRGSSLCNIAILVIDIMHG 106 Query: 165 CPQPQTSEHLAAIEIMKLKHILILQNKIDLVKE---------------------SQAKEQ 203 Q QT E + + K ++ NKID + + + + + Sbjct: 107 LEQ-QTIESIKLLRDRKAPF-VVALNKIDRLYDWKAIPNNSFRDSFAKQSRAVQEEFQSR 164 Query: 204 YEQI------------LAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFT 251 Y +I L F +++ I+P SA + + +++ + + Sbjct: 165 YSKIQLELAEQGLNSELYFQNKNMSKYVSIVPTSAVTGEGVPDLLWLLLELT---QKRMS 221 Query: 252 SEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMC 311 + L+ + + +V + G + G L+ G I + + + + Sbjct: 222 KQ--LMYLSHVEATILEVKVVEGFGTTIDVILSNGYLREGDRIVLCGMNGPIVTNIRALL 279 Query: 312 KPI---FSKIVSLFAEHNDLQYA 331 P ++ S + H +++ A Sbjct: 280 TPQPLRELRLKSEYVHHKEVKAA 302 >3WBI-A nrPDB Length = 606 Score = 88.0 bits (216), Expect = 9e-18, Method: Composition-based stats. Identities = 49/323 (15%), Positives = 105/323 (32%), Gaps = 65/323 (20%) Query: 45 GTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYRS 104 +GHV GK+ ++ I R ++ G A ++ P Sbjct: 13 CILGHVDTGKTKLLDKI-------------RQTNVQGGEAGGITQQIGATYFPIDAIKAK 59 Query: 105 CGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNES 164 E T V + +D PGH+ G+++ + A+L+I Sbjct: 60 TKVMAEYEKQTFD---------VPGLLVIDTPGHESFSNLRSRGSSLCNIAILVIDIMHG 110 Query: 165 CPQPQTSEHLAAIEIMKLKHILILQNKIDLVKE---------------------SQAKEQ 203 Q QT E + + K ++ NKID + + + + + Sbjct: 111 LEQ-QTIESIKLLRDRKAPF-VVALNKIDRLYDWKAIPNNSFRDSFAKQSRAVQEEFQSR 168 Query: 204 YEQI------------LAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFT 251 Y +I L F +++ I+P SA + + +++ + + Sbjct: 169 YSKIQLELAEQGLNSELYFQNKNMSKYVSIVPTSAVTGEGVPDLLWLLLELT---QKRMS 225 Query: 252 SEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMC 311 + L+ + + +V + G + G L+ G I + + + + Sbjct: 226 KQ--LMYLSHVEATILEVKVVEGFGTTIDVILSNGYLREGDRIVLCGMNGPIVTNIRALL 283 Query: 312 KPI---FSKIVSLFAEHNDLQYA 331 P ++ S + H +++ A Sbjct: 284 TPQPLRELRLKSEYVHHKEVKAA 306 >4V8Z-CV nrPDB Length = 586 Score = 86.1 bits (211), Expect = 3e-17, Method: Composition-based stats. Identities = 49/323 (15%), Positives = 105/323 (32%), Gaps = 65/323 (20%) Query: 45 GTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYRS 104 +GHV GK+ ++ I R ++ G A ++ P Sbjct: 9 CILGHVDTGKTKLLDKI-------------RQTNVQGGEAGGITQQIGATYFPIDAIKAK 55 Query: 105 CGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNES 164 E T V + +D PGH+ G+++ + A+L+I Sbjct: 56 TKVMAEYEKQTFD---------VPGLLVIDTPGHESFSNLRSRGSSLCNIAILVIDIMHG 106 Query: 165 CPQPQTSEHLAAIEIMKLKHILILQNKIDLVKE---------------------SQAKEQ 203 Q QT E + + K ++ NKID + + + + + Sbjct: 107 LEQ-QTIESIKLLRDRKAPF-VVALNKIDRLYDWKAIPNNSFRDSFAKQSRAVQEEFQSR 164 Query: 204 YEQI------------LAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFT 251 Y +I L F +++ I+P SA + + +++ + + Sbjct: 165 YSKIQLELAEQGLNSELYFQNKNMSKYVSIVPTSAVTGEGVPDLLWLLLELT---QKRMS 221 Query: 252 SEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMC 311 + L+ + + +V + G + G L+ G I + + + + Sbjct: 222 KQ--LMYLSHVEATILEVKVVEGFGTTIDVILSNGYLREGDRIVLCGMNGPIVTNIRALL 279 Query: 312 KPI---FSKIVSLFAEHNDLQYA 331 P ++ S + H +++ A Sbjct: 280 TPQPLRELRLKSEYVHHKEVKAA 302 >5TY0-A nrPDB Length = 422 Score = 83.0 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 39/223 (17%), Positives = 77/223 (34%), Gaps = 26/223 (11%) Query: 43 NIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECY 102 NIG HV GK+T + + ++ K+G + +D + Sbjct: 13 NIGIAAHVDAGKTTTTERVLYYT----------GMSHKIGEVHDGAATMDWMVQEQERGI 62 Query: 103 RSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGN 162 ++T G F+ R ++ +D PGH M + V+D A+++ Sbjct: 63 TITSAATT----CYWSGMDKQFESHR-INIIDTPGHVDFMIEVERSLRVLDGAVVVFDSV 117 Query: 163 ESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPII 222 +PQ+ + I + NK+D + + QI + T Sbjct: 118 AGV-EPQSETVWRQANKYGVPRI-VFVNKMDRMGAN-FLRVVSQIKQRLGST-------- 166 Query: 223 PISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVN 265 P+ QL E + ++ I + + E + + + D+ Sbjct: 167 PVVLQLPIGAEEEFKGVIDLIKMKAIHWDEENKGMTFKYVDIP 209 Score = 37.6 bits (85), Expect = 0.011, Method: Composition-based stats. Identities = 16/117 (13%), Positives = 35/117 (29%), Gaps = 20/117 (17%) Query: 198 SQAKEQYEQILAFVQGTVAEG----------APIIPISAQLKYNIEVVCEYIVKKIPVPP 247 + E+Y + F + + + P+ SA ++ V + +++ +P P Sbjct: 232 EELMEKYLEGEEFTEAEIKKALRHLTITNKVVPVFCGSAFKNKGVQAVLDGVIEYLPSPT 291 Query: 248 RDFTSE----------PRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEI 294 + + F D G + G+LK G + Sbjct: 292 DIPDIQGVDEHGDVIHRKTSYDEPFSALAFKIATDPFVGTLTYFRAYSGILKSGDTV 348 >5VH6-A nrPDB Length = 409 Score = 81.9 bits (200), Expect = 6e-16, Method: Composition-based stats. Identities = 50/297 (16%), Positives = 97/297 (32%), Gaps = 47/297 (15%) Query: 29 TPLSHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKI 88 ++ E + NIG + H+ GK+T + I K+G + Sbjct: 2 NAMAREFSLEKTR-NIGIMAHIDAGKTTTTERI----------LFYTGRIHKIGETHEGA 50 Query: 89 YKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNG 148 ++D + ++T ++ V+ +D PGH + Sbjct: 51 SQMDWMEQEQERGITITSAATTAQWKGY------------RVNIIDTPGHVDFTVEVERS 98 Query: 149 AAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQIL 208 V+D A+ ++ +PQT + I + NK+D + + Sbjct: 99 LRVLDGAVAVLDAQSGV-EPQTETVWRQATTYGVPRI-VFVNKMDKIGADFLYS-----V 151 Query: 209 AFVQGTVAEGAPII--PISAQLKY-NIEVVCEYI-------------VKKIPVPPRDFTS 252 ++ + A I PI A+ + I + E + K+IP ++ Sbjct: 152 GTLRDRLQANAHAIQLPIGAEDNFEGIIDLVENVAYFYEDDLGTRSDAKEIPEEYKEQAE 211 Query: 253 EPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQ-EIEVRPGIVSKDSEGK 308 E R +I + L+G LK ++ G +E P +V + K Sbjct: 212 ELRNSLIEAVCELDEELMDKYLEGEEITIDELKAGIRKGTLNVEFYPVLVGSAFKNK 268 >3ZZ0-A nrPDB Length = 693 Score = 81.5 bits (199), Expect = 7e-16, Method: Composition-based stats. Identities = 37/214 (17%), Positives = 70/214 (32%), Gaps = 34/214 (15%) Query: 31 LSHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYK 90 ++ E + NIG I H+ GK+T + I K+G + + Sbjct: 1 MAREFSLEKTR-NIGIIAHIDAGKTTTTERILYYTGRIH----------KIGETHEGASQ 49 Query: 91 LDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAA 150 +D + ++T + V+ +D PGH + Sbjct: 50 MDWMEQEQDRGITITSAATTAAWEGH------------RVNIIDTPGHVDFTVEVERSLR 97 Query: 151 VMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAF 210 V+D A+ ++ +PQT + I + NK+D + +E ++ Sbjct: 98 VLDGAVTVLDAQSGV-EPQTETVWRQATTYGVPRI-VFVNKMDKLG-----ANFEYSVST 150 Query: 211 VQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIP 244 + + A I QL E E I+ + Sbjct: 151 LHDRLQANAAPI----QLPIGAEDEFEAIIDLVE 180 >4V6W-Az nrPDB Length = 844 Score = 81.5 bits (199), Expect = 8e-16, Method: Composition-based stats. Identities = 36/197 (18%), Positives = 68/197 (34%), Gaps = 19/197 (9%) Query: 35 VISRQATI-NIGTIGHVAHGKSTVVKAISG----VHTVRFKNELERNITIKLGYANAKIY 89 ++ ++ I N+ I HV HGKST+ ++ + + + I Sbjct: 12 LMDKKRNIRNMSVIAHVDHGKSTLTDSLVSKAGIIAGAKAGETRFTDTRKDEQERCITIK 71 Query: 90 KLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGA 149 E + PD+ + G ++ +D PGH + + Sbjct: 72 STAISMYFEVEEKDLVFITHPDQREKECKGFL--------INLIDSPGHVDFSSEVTAAL 123 Query: 150 AVMDAALLLIAGNES-CPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQIL 208 V D AL+++ C Q +T A E +K ++ NK+D + E Sbjct: 124 RVTDGALVVVDCVSGVCVQTETVLRQAIAERIKP---ILFMNKMDRALLELQLDAEELYQ 180 Query: 209 AFVQGTVAEGAPIIPIS 225 F + + E +I + Sbjct: 181 TFQR--IVENVNVIIAT 195 Score = 33.3 bits (74), Expect = 0.24, Method: Composition-based stats. Identities = 37/228 (16%), Positives = 75/228 (32%), Gaps = 35/228 (15%) Query: 249 DFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGK 308 D + + + + G A G + G + GQ+ + + + Sbjct: 375 DPDGPLMMYISKMVPTSDKGRFY-------AFGRVFAGKVATGQKCRIMGPNYTPGKKED 427 Query: 309 LMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIF 368 L K I I+ + ++ G + G+ + + G + A Sbjct: 428 LYEKAIQRTILMMGRYVEAIEDVPSGNICGL-----VGVDQFLVKTGTITTFKDAHNMKV 482 Query: 369 TELEISYFLLRRLLGVRT--------EGDKKAAKVQKL------SKNEVLMVNIGSLSTG 414 + +S ++R + + EG K+ AK + E ++ G L Sbjct: 483 MKFSVSP-VVRVAVEPKNPADLPKLVEGLKRLAKSDPMVQCIIEESGEHIIAGAGELHLE 541 Query: 415 GRVSAVKADLGKIVLTN--PV------CTEVGEKIALSRRVEKHWRLI 454 + ++ D I L PV +E +++ LS+ KH RL+ Sbjct: 542 ICLKDLEEDHACIPLKKSDPVVSYRETVSEESDQMCLSKSPNKHNRLL 589 >6BK7-A nrPDB Length = 407 Score = 80.3 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 40/222 (18%), Positives = 75/222 (33%), Gaps = 32/222 (14%) Query: 29 TPLSHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKI 88 ++ E + NIG + HV GK+T + I K+G + Sbjct: 2 NAMAREFSLEKTR-NIGIMAHVDAGKTTTTERILYYTGKIH----------KIGETHEGA 50 Query: 89 YKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNG 148 ++D + ++T ++ V+ +D PGH + Sbjct: 51 SQMDWMEQEQERGITITSAATTAQWKGY------------RVNIIDTPGHVDFTIEVQRS 98 Query: 149 AAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQIL 208 V+D A+ ++ +PQT K+ I + NK+D + + + Sbjct: 99 LRVLDGAVTVLDSQSGV-EPQTETVWRQATEYKVPRI-VFCNKMDKIGADF----FYSVE 152 Query: 209 AFVQGTVAEGAPI-IPISAQLKYNIEVVCEYIVKKIPVPPRD 249 + A PI IPI A+ + + + I K + D Sbjct: 153 SLHDRLQANAHPIQIPIGAEEDFTG--IIDLIKMKAEIYTND 192 >6N0I-A nrPDB Length = 706 Score = 78.4 bits (191), Expect = 7e-15, Method: Composition-based stats. Identities = 40/231 (17%), Positives = 80/231 (34%), Gaps = 28/231 (12%) Query: 43 NIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECY 102 NIG + HV GK+T + I + K+G + +D + + Sbjct: 15 NIGIVAHVDAGKTTTTERI----------LFYTGVNHKMGEVHDGAATMDWMAQEQERGI 64 Query: 103 RSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGN 162 ++T + G+ F + +D PGH + V+D A+++ +G Sbjct: 65 TITSAATTAFWQ----GSTKQFAHKYRFNIIDTPGHVDFTIEVERSLRVLDGAVVVFSGA 120 Query: 163 ESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKES--QAKEQYEQ---------ILAFV 211 + +PQ+ + + NK+D + +Q +Q LA Sbjct: 121 DGV-EPQSETVWRQANKYHVPRL-AYINKMDRQGADFLRVVKQIDQRLGHHPVPIQLAIG 178 Query: 212 QGTVAEG-APIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRS 261 G ++ + A + + Y ++IP + E R +I + Sbjct: 179 SEENFMGQIDLVKMKAIYWNDADQGTSYREEEIPAELKALADEWRAHMIEA 229 Score = 36.4 bits (82), Expect = 0.030, Method: Composition-based stats. Identities = 30/207 (14%), Positives = 68/207 (32%), Gaps = 33/207 (15%) Query: 204 YEQILAFVQGTVAEG--APIIPISAQLKYNIEVVCEYIVKKIPVPPR-------DFTSEP 254 E+I A ++ P I S+ + ++ + ++ +P P D E Sbjct: 249 IEEIKAGLRQRTIANEIVPTILGSSFKNKGVPLMLDAVIDYLPAPSEIPAIRGTDPDDEE 308 Query: 255 RLIVIRS-----FDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKL 309 + + + F D G + + GVL G + +GK Sbjct: 309 KHLERHADDKEPFSALAFKIATDPFVGTLTFARVYSGVLSSGNAV-------LNSVKGK- 360 Query: 310 MCKPIFSKIVSLFAEHN-DLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIF 368 K ++V + A +++ G + + + D G L + P I Sbjct: 361 --KERIGRMVQMHANQRAEIKDVCAGDIAAL-------IGMKDVTTGDTLCDMDK-PIIL 410 Query: 369 TELEISYFLLRRLLGVRTEGDKKAAKV 395 ++ ++ + +T+ D++ + Sbjct: 411 ERMDFPDPVISVAVEPKTKADQEKMGI 437 >5H7J-A nrPDB Length = 743 Score = 76.8 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 22/170 (12%), Positives = 55/170 (32%), Gaps = 26/170 (15%) Query: 43 NIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECY 102 NIG H+ HGK+T+ + + + + + + + + Sbjct: 26 NIGIAAHIDHGKTTLSDNLLAGAGMISEELAGKQLVLDF--------------DEQEQAR 71 Query: 103 RSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGN 162 ++ + G ++ +D PGH + +D ++++ Sbjct: 72 GITINAANVSMVHNYEGKDYL------INLIDTPGHVDFGGDVTRAMRAIDGVIIVVDAV 125 Query: 163 ESCPQPQTSEHLAAIEIMKLKHI--LILQNKIDLVKESQAKEQYEQILAF 210 E PQT + +++ ++ NK+D + + + F Sbjct: 126 EGV-MPQTE---TVVRQALREYVKPVLFINKVDRLIRELKLTPQQMMERF 171 Score = 31.8 bits (70), Expect = 0.66, Method: Composition-based stats. Identities = 34/188 (18%), Positives = 65/188 (34%), Gaps = 33/188 (17%) Query: 271 VDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQY 330 +D G VA G + G +K GQE+ +++ + ++ I+ + Sbjct: 304 IDKHAGEVATGRVWSGTVKSGQEVY----LINTKRKARIQQVGIYMGPERINM------E 353 Query: 331 AAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDK 390 A P G I T + D M G+ + P E +++ ++ V E Sbjct: 354 AVPAGNIVAVTGL------RDAMAGETVAEEQIEP-----FEALHYVSEPVVTVAIEAKN 402 Query: 391 KAAKVQKL-------SKNEVLMVNIGSLSTGGRVSA-----VKADLGKIVLTNPVCTEVG 438 + + ++ L V I + +S ++ L K+ + EV Sbjct: 403 VKDLPRLIEALRQLAKEDPTLHVKIDEETGQHLLSGMGELHLEVKLYKLKKDWGIDIEVS 462 Query: 439 EKIALSRR 446 E I + R Sbjct: 463 EPIVVYRE 470 >5H7K-A nrPDB Length = 397 Score = 76.8 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 22/170 (12%), Positives = 55/170 (32%), Gaps = 26/170 (15%) Query: 43 NIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECY 102 NIG H+ HGK+T+ + + + + + + + + Sbjct: 26 NIGIAAHIDHGKTTLSDNLLAGAGMISEELAGKQLVLDF--------------DEQEQAR 71 Query: 103 RSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGN 162 ++ + G ++ +D PGH + +D ++++ Sbjct: 72 GITINAANVSMVHNYEGKDYL------INLIDTPGHVDFGGDVTRAMRAIDGVIIVVDAV 125 Query: 163 ESCPQPQTSEHLAAIEIMKLKHI--LILQNKIDLVKESQAKEQYEQILAF 210 E PQT + +++ ++ NK+D + + + F Sbjct: 126 EGV-MPQTE---TVVRQALREYVKPVLFINKVDRLIRELKLTPQQMMERF 171 Score = 32.2 bits (71), Expect = 0.57, Method: Composition-based stats. Identities = 22/109 (20%), Positives = 40/109 (36%), Gaps = 21/109 (19%) Query: 271 VDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQY 330 +D G VA G + G +K GQE+ +++ + ++ I+ + Sbjct: 304 IDKHAGEVATGRVWSGTVKSGQEVY----LINTKRKARIQQVGIYMGPERINM------E 353 Query: 331 AAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLR 379 A P G I T + D M G+ + P E +++L Sbjct: 354 AVPAGNIVAVTGL------RDAMAGETVAEEQIEP-----FEALHYVLE 391 >2P8Y-T nrPDB Length = 842 Score = 75.7 bits (184), Expect = 4e-14, Method: Composition-based stats. Identities = 40/193 (20%), Positives = 69/193 (35%), Gaps = 38/193 (19%) Query: 43 NIGTIGHVAHGKSTVVKAISGVH-------------TVRFKNELERNITIKLGYANAKIY 89 N+ I HV HGKST+ ++ T K+E ER ITIK +Y Sbjct: 21 NMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIK--STAISLY 78 Query: 90 KLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGA 149 + ++ G+S ++ +D PGH + + Sbjct: 79 SEMSDEDVKEIKQKTDGNSFL-------------------INLIDSPGHVDFSSEVTAAL 119 Query: 150 AVMDAALLLIAGNES-CPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQIL 208 V D AL+++ E C Q +T A E +K +++ NK+D + + Sbjct: 120 RVTDGALVVVDTIEGVCVQTETVLRQALGERIKP---VVVINKVDRALLELQVSKEDLYQ 176 Query: 209 AFVQGTVAEGAPI 221 F + + + Sbjct: 177 TFARTVESVNVIV 189 >4FN5-A nrPDB Length = 709 Score = 74.5 bits (181), Expect = 9e-14, Method: Composition-based stats. Identities = 51/294 (17%), Positives = 95/294 (32%), Gaps = 35/294 (11%) Query: 32 SHEVISRQA---TINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKI 88 + NIG HV GK+T + + + KLG + Sbjct: 1 GSHMARTTPINRYRNIGICAHVDAGKTTTTERV----------LFYTGVNHKLGEVHDGA 50 Query: 89 YKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNG 148 D + + T T G++G + R V+ +D PGH + Sbjct: 51 ATTDWMVQEQERG----ITITSAAVTTFWKGSRGQYDNYR-VNVIDTPGHVDFTIEVERS 105 Query: 149 AAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQIL 208 V+D A+++ G PQ+ + I + NK+D + EQI Sbjct: 106 LRVLDGAVVVFCGTSGVE-PQSETVWRQANKYGVPRI-VYVNKMDRQGAN-FLRVVEQIK 162 Query: 209 AFV-------------QGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPR 255 + + +I + A + + Y ++IP +D E R Sbjct: 163 KRLGHTPVPVQLAIGAEENFVGQVDLIKMKAIYWNDDDKGMTYREEEIPAELKDLAEEWR 222 Query: 256 -LIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGK 308 +V + + N+ +G ++ I +G+ E+ P + + K Sbjct: 223 SSMVEAAAEANEELMNKYLEEGELSEAEIKEGLRLRTLACEIVPAVCGSSFKNK 276 Score = 39.1 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 31/221 (14%), Positives = 73/221 (33%), Gaps = 33/221 (14%) Query: 188 LQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPP 247 L NK ++E + E + ++ E P + S+ + +V + ++ +P P Sbjct: 236 LMNK--YLEEGELSEAEIKEGLRLRTLACEIVPAVCGSSFKNKGVPLVLDAVIDYLPAPT 293 Query: 248 RDFTSEPRLIVIRS------------FDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIE 295 + + F D G + + GVL G + Sbjct: 294 EIPAIKGVSPDDETVEDERHADDNEPFSSLAFKIATDPFVGTLTFARVYSGVLSSGDSV- 352 Query: 296 VRPGIVSKDSEGKLMCKPIFSKIVSLFA-EHNDLQYAAPGGLIGVGTKIDPTLCRADRMV 354 +GK K ++V + A + +++ G + + + D Sbjct: 353 ------LNSVKGK---KERVGRMVQMHANQREEIKEVRAGDIAAL-------IGMKDVTT 396 Query: 355 GQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKV 395 G L ++ P I ++ ++ + +T+ D++ + Sbjct: 397 GDTLCSIEK-PIILERMDFPEPVISVAVEPKTKADQEKMGI 436 >5TV2-A nrPDB Length = 405 Score = 73.8 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 40/202 (19%), Positives = 74/202 (36%), Gaps = 26/202 (12%) Query: 43 NIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECY 102 NIG HV GK+T + I ++ K+G + +D + Sbjct: 12 NIGICAHVDAGKTTTTERI----------LFYTGLSHKIGEVHDGAATMDWMEQEQERGI 61 Query: 103 RSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGN 162 ++T + G + F+ R V+ +D PGH + V+D A+++ G+ Sbjct: 62 TITSAATTTFWR----GMEAQFQDHR-VNIIDTPGHVDFTIEVERSLRVLDGAVVVFCGS 116 Query: 163 ESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPII 222 +PQ+ + + + + NK+D +QI + GA + Sbjct: 117 SGV-EPQSETVWRQADKYHVPRM-VFVNKMDRAGAD-FLRVVDQIKNRL------GANPV 167 Query: 223 PISAQLKYNIEVVCEYIVKKIP 244 PI QL E + ++ I Sbjct: 168 PI--QLNVGAEEDFKGVIDLIK 187 Score = 39.1 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 24/179 (13%), Positives = 49/179 (27%), Gaps = 30/179 (16%) Query: 198 SQAKEQYEQILAFVQGTVAEGAPIIP--ISAQLKYNIEVVCEYIVKKIPVP--------- 246 + + +I ++ ++ SA ++ V + +++ +P P Sbjct: 239 EEGELTEAEIKQALRARTLNNEIVLATCGSAFKNKGVQAVLDAVIEYLPSPIDVPAIKGI 298 Query: 247 -PRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDS 305 D E F D G + + GV+ G + Sbjct: 299 DENDNEVERHADDNEPFSALAFKIATDPFVGTLTFIRVYSGVVNTGDAV----------Y 348 Query: 306 EGKLMCKPIFSKIVSLFA-EHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGA 363 K F +IV + A + +++ G I + D G L Sbjct: 349 NSVKQKKERFGRIVQMHANKREEIKEVRAGD-------IAAAIGLKDVTTGDTLCNSDH 400 >4V7D-BZ nrPDB Length = 711 Score = 73.0 bits (177), Expect = 3e-13, Method: Composition-based stats. Identities = 31/196 (15%), Positives = 64/196 (32%), Gaps = 19/196 (9%) Query: 43 NIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECY 102 NIG H+ GK+T + I + K+G + +D + Sbjct: 11 NIGISAHIDAGKTTTTERI----------LFYTGVNHKIGEVHDGAATMDWMEQEQERGI 60 Query: 103 RSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGN 162 ++T + G ++ R ++ +D PGH + V+D A+++ Sbjct: 61 TITSAATTAFWS----GMAKQYEPHR-INIIDTPGHVDFTIEVERSMRVLDGAVMVYCAV 115 Query: 163 ESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPII 222 QPQ+ K+ I NK+D + + K + G + Sbjct: 116 GGV-QPQSETVWRQANKYKVPRI-AFVNKMDRMGANFLKVVNQIKTRL--GANPVPLQLA 171 Query: 223 PISAQLKYNIEVVCEY 238 + + + + + Sbjct: 172 IGAEEHFTGVVDLVKM 187 Score = 41.4 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 30/203 (14%), Positives = 63/203 (31%), Gaps = 33/203 (16%) Query: 206 QILAFVQGTVAEGAPIIP--ISAQLKYNIEVVCEYIVKKIPVPP------------RDFT 251 +I ++ V I+ SA ++ + + ++ +P P +D Sbjct: 246 EIKGALRQRVLNNEIILVTCGSAFKNKGVQAMLDAVIDYLPSPVDVPAINGILDDGKDTP 305 Query: 252 SEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMC 311 +E F D G + + GV+ G + Sbjct: 306 AERHASDDEPFSALAFKIATDPFVGNLTFFRVYSGVVNSGDTV----------LNSVKAA 355 Query: 312 KPIFSKIVSLFA-EHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTE 370 + F +IV + A + +++ G I + D G L A P I Sbjct: 356 RERFGRIVQMHANKREEIKEVRAGD-------IAAAIGLKDVTTGDTLCDPDA-PIILER 407 Query: 371 LEISYFLLRRLLGVRTEGDKKAA 393 +E ++ + +T+ D++ Sbjct: 408 MEFPEPVISIAVEPKTKADQEKM 430 >6B8D-A nrPDB Length = 408 Score = 72.6 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 28/179 (15%), Positives = 56/179 (31%), Gaps = 17/179 (9%) Query: 43 NIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECY 102 NIG H+ GK+T + I ++ K+G + +D + Sbjct: 15 NIGISAHIDAGKTTTTERI----------LFYTGVSHKIGEVHDGAATMDWMEQEQERGI 64 Query: 103 RSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGN 162 ++T T ++ +D PGH + V+D A+++ Sbjct: 65 TITSAAT-----TAFWSGMSQQFPQHRINVIDTPGHVDFTVEVERSMRVLDGAVMVYCAV 119 Query: 163 ESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPI 221 QPQ+ ++ I NK+D + + + + P+ Sbjct: 120 GGV-QPQSETVWRQANKYEVPRI-AFVNKMDRTGANFLRVVEQLKTRLGANAIPLQLPV 176 Score = 41.4 bits (95), Expect = 9e-04, Method: Composition-based stats. Identities = 28/175 (16%), Positives = 54/175 (30%), Gaps = 30/175 (17%) Query: 203 QYEQILAFVQGTVAEGAPIIP--ISAQLKYNIEVVCEYIVKKIPVP----------PRDF 250 E+I + ++ V I+ SA ++ + + +V+ +P P P + Sbjct: 247 TEEEIKSALRQRVLANEIILVTCGSAFKNKGVQAMLDAVVEYLPAPTDIPAIKGINPDET 306 Query: 251 TSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLM 310 E F D G + + GV+ G + Sbjct: 307 EGERHASDEEPFSSLAFKIATDPFVGNLTFFRVYSGVINSGDTV----------LNSVRQ 356 Query: 311 CKPIFSKIVSLFA-EHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGAL 364 + F +IV + A + +++ G I + D G L A+ A Sbjct: 357 KRERFGRIVQMHANKREEIKEVRAGD-------IAAAIGLKDVTTGDTLCAIDAP 404 >4WQY-BZ nrPDB Length = 758 Score = 72.6 bits (176), Expect = 4e-13, Method: Composition-based stats. Identities = 29/156 (18%), Positives = 50/156 (32%), Gaps = 24/156 (15%) Query: 43 NIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECY 102 NIG H+ GK+T + I K+G + +D R Sbjct: 81 NIGIAAHIDAGKTTTTERILYYTGRIH----------KIGEVHEGAATMDFMEQERERGI 130 Query: 103 RSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGN 162 + T F ++ +D PGH + V+D A+++ + Sbjct: 131 TITAAVTTC------------FWKDHRINIIDTPGHVDFTIEVERSMRVLDGAIVVFDSS 178 Query: 163 ESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKES 198 + +PQ+ E K+ I NK+D Sbjct: 179 QGV-EPQSETVWRQAEKYKVPRI-AFANKMDKTGAD 212 Score = 38.3 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 27/189 (14%), Positives = 61/189 (32%), Gaps = 26/189 (13%) Query: 215 VAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSE---PRLIVIRSF-DVNKPGCE 270 + P+ SA ++++ + +V +P P + P V+ D N P Sbjct: 319 DLKITPVFLGSALKNKGVQLLLDAVVDYLPSPLDIPPIKGTTPEGEVVEIHPDPNGPLAA 378 Query: 271 V------DDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAE 324 + D G + + G L G + + K + + + Sbjct: 379 LAFKIMADPYVGRLTFIRVYSGTLTSGSYV---------YNTTKGRKERVARLLRMHANH 429 Query: 325 HNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGV 384 +++ G L V + + + G L A I +E+ ++ + Sbjct: 430 REEVEELKAGDLGAV-------VGLKETITGDTLVGEDAPRVILESIEVPEPVIDVAIEP 482 Query: 385 RTEGDKKAA 393 +T+ D++ Sbjct: 483 KTKADQEKL 491 >6MTD-v nrPDB Length = 839 Score = 72.2 bits (175), Expect = 5e-13, Method: Composition-based stats. Identities = 36/163 (22%), Positives = 65/163 (39%), Gaps = 31/163 (19%) Query: 35 VISRQATI-NIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDD 93 ++ ++A I N+ I HV HGKST+ ++ + + R ITIK A + Y+L + Sbjct: 11 IMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAGI-----IARCITIK-STAISLFYELSE 64 Query: 94 PSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMD 153 + + ++ +D PGH + + V D Sbjct: 65 NDLNFIKQSKDGAGFL--------------------INLIDSPGHVDFSSEVTAALRVTD 104 Query: 154 AALLLIAGNES-CPQPQTSEHLAAIEIMKLKHILILQNKIDLV 195 AL+++ C Q +T A E +K +++ NK+D Sbjct: 105 GALVVVDCVSGVCVQTETVLRQAIAERIKP---VLMMNKMDRA 144 >6NOT-A nrPDB Length = 707 Score = 70.7 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 34/202 (16%), Positives = 67/202 (33%), Gaps = 33/202 (16%) Query: 43 NIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECY 102 NIG H+ GK+T + I K+G + +D + Sbjct: 20 NIGICAHIDAGKTTTTERILYYTGKSH----------KIGEVHEGGATMDWMEQEQERGI 69 Query: 103 RSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGN 162 ++T + + ++ +D PGH + V+D A+ + G Sbjct: 70 TITSAATTCRWQDKV------------INIIDTPGHVDFTIEVERSLRVLDGAVAVFDGV 117 Query: 163 ESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPII 222 +PQ+ + + + NK+D + + + + ++ + + II Sbjct: 118 AGV-EPQSETVWRQADKYNVPRM-CFVNKMDRMGAD-----FYRCVEMIKDRLGARSLII 170 Query: 223 PISAQLKYNIEVVCEYIVKKIP 244 QL IE + IV I Sbjct: 171 ----QLPIGIEENFKGIVNLIK 188 Score = 41.0 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 31/191 (16%), Positives = 60/191 (31%), Gaps = 27/191 (14%) Query: 200 AKEQYEQILAFVQGTVAEG--APIIPISAQLKYNIEVVCEYIVKKIPVPPR--------- 248 A+ EQI ++ E PI+ SA ++ + + IV +P P Sbjct: 242 AEITEEQIKILIRKGTIEARFYPILCGSAFKNKGVQPLLDAIVDFLPSPIDIGIVKGIEV 301 Query: 249 --DFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSE 306 + + ++ F D G + I G + G + + Sbjct: 302 STSEEKDFPISIVEPFSALAFKIMNDPFVGSLTFIRIYSGKITSGATVI---------NT 352 Query: 307 GKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVG---QVLGAVGA 363 K + I ++ D++ A+ G ++ + D + QV+ Sbjct: 353 VKNKREKIGRMLLMHANNREDIKEASAGDIVAL--AGLKDTSTGDTLSDIDKQVVLERME 410 Query: 364 LPEIFTELEIS 374 PE EL + Sbjct: 411 FPEPVIELAVE 421 >3TR5-A nrPDB Length = 528 Score = 69.5 bits (168), Expect = 3e-12, Method: Composition-based stats. Identities = 31/203 (15%), Positives = 68/203 (33%), Gaps = 29/203 (14%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYR 103 I H GK+T+ + + + F ++ TIK A + Sbjct: 16 FAIISHPDAGKTTLTEKL-----LLFGGAIQLAGTIKSRKAAR---HATSDWMELEKQRG 67 Query: 104 SCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNE 163 +++ +FP ++ +D PGH +D+AL++I + Sbjct: 68 ISVTTSVMQFPYKDYL----------INLLDTPGHADFTEDTYRTLTAVDSALMVIDAAK 117 Query: 164 SCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIP 223 +P+T + + + I+ NK+D + E ++I + ++ P Sbjct: 118 GV-EPRTIKLMEVCRLRHTP-IMTFINKMDR-DTRPSIELLDEIESILR------IHCAP 168 Query: 224 ISAQLKYNIEVVCEYIVKKIPVP 246 ++ + + I I Sbjct: 169 VT--WPIGMGKYFKGIYHLIEDA 189 Score = 36.0 bits (81), Expect = 0.032, Method: Composition-based stats. Identities = 36/207 (17%), Positives = 68/207 (32%), Gaps = 22/207 (10%) Query: 214 TVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPP-RDFTSEPRLIVIRSFD---VNKPGC 269 E PI SA + + + + VK+ P P R+ S F Sbjct: 246 LKGELTPIFFGSAINNFGVGELLDAFVKEAPPPQGRETNSRLVKPEEEKFSGFVFKIQAN 305 Query: 270 EVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQ 329 + +A I G + G ++ V E ++ F + + + + Sbjct: 306 MDPGHRDRIAFLRIASGQYQKG----MKAYHVRLKKEIQINNALTF-----MAGKRENAE 356 Query: 330 YAAPGGLIGVGTKIDPTL--CRADRMVGQVLGAVGALPEIFTELEIS-----YFLLRRLL 382 A PG +IG+ + + G E+F + + LL+ L Sbjct: 357 EAWPGDIIGLHNHGTIQIGDTFTQGERFKFTGIPNFASELFRLVRLKDPLKQKALLKGLT 416 Query: 383 GVRTEGDKKAAKVQKLSKNEVLMVNIG 409 + EG + + L NE+++ +G Sbjct: 417 QLSEEGATQLF--RPLDSNELILGAVG 441 >3VQT-A nrPDB Length = 548 Score = 67.6 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 31/172 (18%), Positives = 58/172 (33%), Gaps = 25/172 (14%) Query: 28 LTPLSHEVISRQATI-----NIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLG 82 L P + SR I H GK+T+ + + + F ++ ++K Sbjct: 13 LVPRGSHMSSRLEREAARRRTFAIISHPDAGKTTLTEKL-----LLFGGAIQMAGSVKAR 67 Query: 83 YANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILM 142 A A+ D + R S + R V+ +D PGH Sbjct: 68 KA-ARHATSDWMAMERERGISVTTSVMQFPYRD------------RVVNLLDTPGHQDFS 114 Query: 143 ATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDL 194 +D+AL++I + + QT + + + ++ NK+D Sbjct: 115 EDTYRVLTAVDSALVVIDAAKGV-EAQTRKLMDVCRMRATP-VMTFVNKMDR 164 >4V89-AW nrPDB Length = 534 Score = 66.4 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 32/185 (17%), Positives = 63/185 (34%), Gaps = 25/185 (13%) Query: 28 LTPLSHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAK 87 L+P EV R+ I H GK+T+ + + + F ++ T+K +N Sbjct: 3 LSPYLQEVAKRRT---FAIISHPDAGKTTITEKV-----LLFGQAIQTAGTVKGRGSN-- 52 Query: 88 IYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLN 147 + +++ +FP V+ +D PGH+ Sbjct: 53 -QHAKSDWMEMEKQRGISITTSVMQFPYHDCL----------VNLLDTPGHEDFSEDTYR 101 Query: 148 GAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDL--VKESQAKEQYE 205 +D L++I + +T + + + IL NK+D + ++ E Sbjct: 102 TLTAVDCCLMVIDAAKGVED-RTRKLMEVTRLRDTP-ILTFMNKLDRDIRDPMELLDEVE 159 Query: 206 QILAF 210 L Sbjct: 160 NELKI 164 >3JB9-B nrPDB Length = 984 Score = 64.9 bits (156), Expect = 8e-11, Method: Composition-based stats. Identities = 29/154 (18%), Positives = 55/154 (35%), Gaps = 24/154 (15%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYR 103 GH+ HGKS ++ + K R++ + D E Sbjct: 144 FIVAGHLHHGKSALLDLLVYYTHPDTKPPKRRSL------------RYTDTHYLERERVM 191 Query: 104 SCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNE 163 S S+ +D+ G F+ +D PGH + + A+ D +L++ E Sbjct: 192 SIKSTPLTLAVSDMKGKTFAFQC------IDTPGHVDFVDEVAAPMAISDGVVLVVDVIE 245 Query: 164 SCPQPQTS--EHLAAIEIMKLKHILILQNKIDLV 195 T +H ++ I+++ NK+D + Sbjct: 246 GVMINTTRIIKHAILHDMP----IVLVLNKVDRL 275 >1WDT-A nrPDB Length = 665 Score = 63.4 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 39/251 (15%), Positives = 79/251 (31%), Gaps = 36/251 (14%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYR 103 + +GH GK+T+ +A+ + + T Y P + +R Sbjct: 12 VALVGHAGSGKTTLTEALLYKTGAKERRGRVEEGTTTTDYT------------PEAKLHR 59 Query: 104 SCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNE 163 + + G V +D PG+ + + DAAL+ ++ Sbjct: 60 TTVRT----------GVAPLLFRGHRVFLLDAPGYGDFVGEIRGALEAADAALVAVSAEA 109 Query: 164 SCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIP 223 T E + L ++++ K+D + A E + + + + P+ Sbjct: 110 GVQVG-TERAWTVAERLGLPRMVVV-TKLDKGGDYYAL--LEDLRSTLGPILPIDLPLYE 165 Query: 224 ISAQLKYNIEVVC---------EYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDL 274 + I+V E ++P R+ R V+ + G L Sbjct: 166 GGKWVGL-IDVFHGKAYRYENGEEREAEVPPEERERVQRFRQEVLEAIVETDEGLLEKYL 224 Query: 275 KGGVAGGSILK 285 +G G L+ Sbjct: 225 EGEEVTGEALE 235 Score = 43.7 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 26/120 (21%), Positives = 50/120 (41%), Gaps = 18/120 (15%) Query: 220 PIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVA 279 P+ S + + + + E I++ +P P F P + + F V +VD G VA Sbjct: 249 PVALASGEREIGVLPLLELILEALPSPTERFGDGP--PLAKVFKV-----QVDPFMGQVA 301 Query: 280 GGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGV 339 + +G LK G ++ G V + P+ ++ +++ A G ++GV Sbjct: 302 YLRLYRGRLKPGDSLQSEAGQVRLPH----LYVPMGKDLL-------EVEEAEAGFVLGV 350 >6ID0-C nrPDB Length = 972 Score = 61.4 bits (147), Expect = 9e-10, Method: Composition-based stats. Identities = 29/153 (18%), Positives = 49/153 (32%), Gaps = 20/153 (13%) Query: 43 NIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECY 102 N+ GH+ HGK+ V + + E+ + L Y + + + Sbjct: 131 NVTLCGHLHHGKTCFVDCL----IEQTHPEIRKRYDQDLCYTDILFTEQE---------R 177 Query: 103 RSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGN 162 STP K + +D PGH + G + D +L I Sbjct: 178 GVGIKSTPVTVVLPDTKGKSYL-----FNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAA 232 Query: 163 ESCPQPQTSEHLAAIEIMKLKHILILQNKIDLV 195 E T + +L + + NKID + Sbjct: 233 EGV-MLNTERLIKHAVQERLA-VTVCINKIDRL 263 >5G06-P nrPDB Length = 747 Score = 60.3 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 76/473 (16%), Positives = 144/473 (30%), Gaps = 78/473 (16%) Query: 33 HEVISRQA-TINIGTIGHVAHGKSTVVKAISG----VHTVRFKNELERNITIKLGYANAK 87 H I+ + +G GKST++ + + + +++ + +N+ Sbjct: 258 HSFIATHPLNLTCLFLGDTNAGKSTLLGHLLYDLNEISMSSMRELQKKSSNLDPSSSNSF 317 Query: 88 IYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDI-LMATML 146 LD+ R + E P + ++ +D PG L Sbjct: 318 KVILDNTKTERENGFSMFKKVIQVENDLLPPSST--------LTLIDTPGSIKYFNKETL 369 Query: 147 NGAAVMD--AALLLIAGN--------ESCPQPQTSEHLAAIE-----IMKLKHILILQNK 191 N D +L+I N + P Q E L I KH++IL NK Sbjct: 370 NSILTFDPEVYVLVIDCNYDSWEKSLDG-PNNQIYEILKVISYLNKNSACKKHLIILLNK 428 Query: 192 IDLVK-ESQAKEQYEQILAFVQGTVAE----GAPIIPISAQLKYNIEVVCEYI------- 239 DL+ + E + L +V + IP S L N+ Sbjct: 429 ADLISWDKHRLEMIQSELNYVLKENFQWTDAEFQFIPCSGLLGSNLNKTENITKSKYKSE 488 Query: 240 ---VKKIPVPPRDFT--SEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILK--------- 285 + +P T S+ L+V + + + G + S+L+ Sbjct: 489 FDSINYVPEWYEGPTFFSQLYLLVEHNMN-KIETTLEEPFVGTILQSSVLQPIAEINYVS 547 Query: 286 -------GVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIG 338 G ++ GQ IE+ G + +I+ ++N + ++ Sbjct: 548 LKVLINSGYIQSGQTIEIHTQYEDFHYYGIVSRMKNSKQILETNTKNN-ISVGLNPDILE 606 Query: 339 VGTKI----DPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAK 394 V KI D T + G ++ + L + LL L + + A Sbjct: 607 VLVKIHNTEDFTKKQFHIRKGDIIIHSRKTNTLSPNLPNTLKLL--ALRLIKLSIQTHAL 664 Query: 395 VQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRV 447 + L++ L KI+ TN + + + + + Sbjct: 665 SDPVDLGSELLLYHNLTHNA-------VKLVKILGTNDISINPNQSLIVEVEI 710 >4ZKD-A nrPDB Length = 499 Score = 60.3 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 76/473 (16%), Positives = 144/473 (30%), Gaps = 78/473 (16%) Query: 33 HEVISRQA-TINIGTIGHVAHGKSTVVKAISG----VHTVRFKNELERNITIKLGYANAK 87 H I+ + +G GKST++ + + + +++ + +N+ Sbjct: 10 HSFIATHPLNLTCLFLGDTNAGKSTLLGHLLYDLNEISMSSMRELQKKSSNLDPSSSNSF 69 Query: 88 IYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDI-LMATML 146 LD+ R + E P + ++ +D PG L Sbjct: 70 KVILDNTKTERENGFSMFKKVIQVENDLLPPSST--------LTLIDTPGSIKYFNKETL 121 Query: 147 NGAAVMD--AALLLIAGN--------ESCPQPQTSEHLAAIE-----IMKLKHILILQNK 191 N D +L+I N + P Q E L I KH++IL NK Sbjct: 122 NSILTFDPEVYVLVIDCNYDSWEKSLDG-PNNQIYEILKVISYLNKNSACKKHLIILLNK 180 Query: 192 IDLVK-ESQAKEQYEQILAFVQGTVAE----GAPIIPISAQLKYNIEVVCEYI------- 239 DL+ + E + L +V + IP S L N+ Sbjct: 181 ADLISWDKHRLEMIQSELNYVLKENFQWTDAEFQFIPCSGLLGSNLNKTENITKSKYKSE 240 Query: 240 ---VKKIPVPPRDFT--SEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILK--------- 285 + +P T S+ L+V + + + G + S+L+ Sbjct: 241 FDSINYVPEWYEGPTFFSQLYLLVEHNMN-KIETTLEEPFVGTILQSSVLQPIAEINYVS 299 Query: 286 -------GVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIG 338 G ++ GQ IE+ G + +I+ ++N + ++ Sbjct: 300 LKVLINSGYIQSGQTIEIHTQYEDFHYYGIVSRMKNSKQILETNTKNN-ISVGLNPDILE 358 Query: 339 VGTKI----DPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAK 394 V KI D T + G ++ + L + LL L + + A Sbjct: 359 VLVKIHNTEDFTKKQFHIRKGDIIIHSRKTNTLSPNLPNTLKLL--ALRLIKLSIQTHAL 416 Query: 395 VQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRV 447 + L++ L KI+ TN + + + + + Sbjct: 417 SDPVDLGSELLLYHNLTHNA-------VKLVKILGTNDISINPNQSLIVEVEI 462 >3R9W-A nrPDB Length = 307 Score = 58.4 bits (139), Expect = 6e-09, Method: Composition-based stats. Identities = 40/254 (15%), Positives = 78/254 (30%), Gaps = 39/254 (15%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYR 103 + +G GKST++ + G + P Sbjct: 12 VAIVGKPNVGKSTLLNNLLGTKVS-----------------------IISPKAGTTRMRV 48 Query: 104 SCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNE 163 + P+E T G ++ + D GH ++ D L +I E Sbjct: 49 LGVKNIPNEAQIIFLDTPGIYEPKKS----DVLGH-SMVEIAKQSLEEADVILFMIDATE 103 Query: 164 SCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIP 223 + I+ + ++++ NKID + + + ++ + E I+P Sbjct: 104 GWRPRDEEIYQNFIKPLNKP-VIVVINKIDKIGPA---KNVLPLIDEIHKKHPELTEIVP 159 Query: 224 ISAQLKYNIEVVCEYIVKKIPV-----PPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGV 278 ISA N++ + + I+K +P P T P ++ K + Sbjct: 160 ISALKGANLDELVKTILKYLPEGEPLFPEDMITDLPLRLLAAEIVREKAMMLTREEVPTS 219 Query: 279 AGGSILKGVLKVGQ 292 I +K G Sbjct: 220 IAVKIN--EIKPGD 231 >5KH0-A nrPDB Length = 396 Score = 54.5 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 24/137 (17%), Positives = 50/137 (36%), Gaps = 21/137 (15%) Query: 115 TDIPGTKGNFKLVRHVSFVDCPGHDIL-------MATMLNGAAVMDAALLLIAGNESCPQ 167 TD V ++ +D PG D + + D +L++ + Sbjct: 44 TDPVFKSMELSPVGPITLIDTPGLDDVGELGIKRIKKAKKSLYRADCGILIVDDIPGNFE 103 Query: 168 PQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQ 227 Q + + +++ + I NKID + +++Y++ PI+ +SA Sbjct: 104 EQI---IKLFKELEIPY-FIAINKIDTIDHENIEKEYKKY----------NVPILKVSAL 149 Query: 228 LKYNIEVVCEYIVKKIP 244 K E + + I +P Sbjct: 150 KKIGFEKIGKTINSILP 166 >1MKY-A nrPDB Length = 439 Score = 51.8 bits (122), Expect = 6e-07, Method: Composition-based stats. Identities = 36/230 (15%), Positives = 82/230 (35%), Gaps = 25/230 (10%) Query: 144 TMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHI--LILQNKIDLVKESQAK 201 M+ D L ++ G T E + + ++ + +++ NK + Sbjct: 77 NMIR---EADLVLFVVDGKRGI----TKEDESLADFLRKSTVDTILVANKA-----ENLR 124 Query: 202 EQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLI-VIR 260 E ++ + IP+SA+ N++ + E I+KK+ D S+P + I+ Sbjct: 125 EFEREVKPELYSLGFGEP--IPVSAEHNINLDTMLETIIKKLEEKGLDLESKPEITDAIK 182 Query: 261 SFDVNKPGCEVDDLKGGVAG-----GSILKGVLK--VGQEIEVRP-GIVSKDSEGKLMCK 312 V +P L + S + G + V E+ + V D+ G Sbjct: 183 VAIVGRPNVGKSTLFNAILNKERALVSPIPGTTRDPVDDEVFIDGRKYVFVDTAGLRRKS 242 Query: 313 PIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVG 362 + + V ++ + + ++ + + R D+ + ++ G Sbjct: 243 RVEPRTVEKYSNYRVVDSIEKADVVVIVLDATQGITRQDQRMAGLMERRG 292 Score = 49.1 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 37/237 (15%), Positives = 79/237 (33%), Gaps = 32/237 (13%) Query: 17 RQDLTTLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERN 76 + +L +L + P+S E IN+ T+ + I + E + Sbjct: 131 KPELYSLGFGEPIPVSAEH-----NINLDTM---------LETIIKKLEEKGLDLESKPE 176 Query: 77 ITIKLGYANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCP 136 IT + A + + + +P T P F R FVD Sbjct: 177 ITDAIKVAIVGRPNVGKSTLFNAILNKERALVSPIPGTTRDPVDDEVFIDGRKYVFVDTA 236 Query: 137 GHDILMA------------TMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKH 184 G +++ D ++++ + + Q +E Sbjct: 237 GLRRKSRVEPRTVEKYSNYRVVDSIEKADVVVIVLDATQGITR-QDQRMAGLMERRGRAS 295 Query: 185 ILILQNKIDLVKESQAKEQYEQILAFVQG--TVAEGAPIIPISAQLKYNIEVVCEYI 239 +++ NK DLV + ++Y++ + + +P+I SA +NI+ + + + Sbjct: 296 VVVF-NKWDLVVHRE--KRYDEFTKLFREKLYFIDYSPLIFTSADKGWNIDRMIDAM 349 >1U0L-A nrPDB Length = 301 Score = 48.3 bits (113), Expect = 6e-06, Method: Composition-based stats. Identities = 19/97 (19%), Positives = 37/97 (38%), Gaps = 5/97 (5%) Query: 149 AAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQIL 208 A +D +L++ + + +++ NK+DL E ++ ++ Sbjct: 82 VANVDQVILVVTVKMPETSTYIIDKFLVLAEKNELETVMVINKMDLYDEDDLRK-VRELE 140 Query: 209 AFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPV 245 G PI+ SA+ IE + EY+ KI Sbjct: 141 EIYSGLY----PIVKTSAKTGMGIEELKEYLKGKIST 173 >3K53-A nrPDB Length = 271 Score = 46.8 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 33/198 (16%), Positives = 76/198 (38%), Gaps = 45/198 (22%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYR 103 + +G+ GK+T+ A++G+ R +T++ + + + P Y Sbjct: 6 VALVGNPNVGKTTIFNALTGL---RQHVGNWPGVTVEKKEGIMEYREKEFLVVDLPGIYS 62 Query: 104 SCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNE 163 S +L+ +D G+ ++ +++ +M Sbjct: 63 LTAHSID--------------ELIARNFILD--GNADVIVDIVDSTCLM----------- 95 Query: 164 SCPQPQTSEHLAAIEI--MKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPI 221 +E+ M++K+I+++ NK DL+K+ AK +++ + G P+ Sbjct: 96 -------RNLFLTLELFEMEVKNIILVLNKFDLLKKKGAKIDIKKMRKEL------GVPV 142 Query: 222 IPISAQLKYNIEVVCEYI 239 IP +A+ +E + I Sbjct: 143 IPTNAKKGEGVEELKRMI 160 >5HXB-X nrPDB Length = 199 Score = 45.6 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 24/185 (12%), Positives = 59/185 (31%), Gaps = 31/185 (16%) Query: 263 DVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLF 322 + P + G V G + G + GQ++ + P +++ + Sbjct: 4 PIRLPIVDKYKDMGTVVLGKLESGSICKGQQLVMMP-------------NKHNVEVLGIL 50 Query: 323 AEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLL 382 ++ + APG + + K + + + G +L L + ++ Sbjct: 51 SDDVETDTVAPGENLKIRLK---GIEEEEILPGFILCDPNNLCHSGRTFDAQIVIIEHKS 107 Query: 383 GVRTEGDKKAAKVQKLSKNEVLMVN--IGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEK 440 + N VL ++ I + + V G+ T P + ++ Sbjct: 108 ------------IICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPRFVK-QDQ 154 Query: 441 IALSR 445 + ++R Sbjct: 155 VCIAR 159 >1YVD-A nrPDB Length = 169 Score = 45.6 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 22/143 (15%), Positives = 46/143 (32%), Gaps = 11/143 (7%) Query: 107 SSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDIL--MATMLNGAAVMDAALLLIAGNES 164 + P + + T + D G + +A M + A+++ + Sbjct: 33 NINPTIGASFMTKTVQYQNELHKFLIWDTAGQERFRALAPMYYRGSAA--AIIVYDITKE 90 Query: 165 CPQPQTSEHLAAIEIMKLKHILILQ--NKIDLVKESQAKEQYEQILAFVQGTVAEGAPII 222 + + I++ NK DL + E+ + A + A + Sbjct: 91 ETFSTLKNWVRELRQHGPPSIVVAIAGNKCDLTDVREVMERDAKDYA-----DSIHAIFV 145 Query: 223 PISAQLKYNIEVVCEYIVKKIPV 245 SA+ NI + I ++IP Sbjct: 146 ETSAKNAININELFIEISRRIPS 168 >2QTH-A nrPDB Length = 364 Score = 44.5 bits (103), Expect = 9e-05, Method: Composition-based stats. Identities = 34/200 (17%), Positives = 70/200 (35%), Gaps = 37/200 (18%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYR 103 IG +G+ GK+++ +++G+ + P+ Y Sbjct: 182 IGIVGYTNSGKTSLFNSLTGLTQKV---------------------DTKLFTTMSPKRYA 220 Query: 104 SCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGN- 162 ++ + +G + FV L+ A DA +L+I Sbjct: 221 IPINNRKIMLVDTVGFIRGIPPQIVDAFFV-----------TLSEAKYSDALILVIDSTF 269 Query: 163 -ESCPQPQTSEHLAAIEIMKL--KHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGA 219 E+ + + + K IL+ NKID + K+ + + + + Sbjct: 270 SENLLIETLQSSFEILREIGVSGKPILVTLNKIDKINGDLYKKL-DLVEKLSKELYSPIF 328 Query: 220 PIIPISAQLKYNIEVVCEYI 239 +IPISA + N+E++ + I Sbjct: 329 DVIPISALKRTNLELLRDKI 348 >2CXX-A nrPDB Length = 190 Score = 44.1 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 39/210 (18%), Positives = 69/210 (32%), Gaps = 41/210 (19%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYR 103 I G GKST++ ++G + + +T K+ K +K+ D Sbjct: 4 IIFAGRSNVGKSTLIYRLTG---KKVRRGKRPGVTRKIIEIEWKNHKIIDMP-------- 52 Query: 104 SCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGN- 162 F +P V F+ + +D A+L++ G Sbjct: 53 ------GFGFMMGLPKEVQERIKDEIVHFI-----EDNAKN-------IDVAVLVVDGKA 94 Query: 163 ---------ESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQG 213 + P E + + + I + NK+D +K Q + V Sbjct: 95 APEIIKRWEKRGEIPIDVEFYQFLRELDIPTI-VAVNKLDKIKNVQEVINFLAEKFEVPL 153 Query: 214 TVAEGAPIIPISAQLKYNIEVVCEYIVKKI 243 + + IPISA+ NIE + I + I Sbjct: 154 SEIDKV-FIPISAKFGDNIERLKNRIFEVI 182 >2E87-A nrPDB Length = 357 Score = 43.7 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 36/210 (17%), Positives = 67/210 (31%), Gaps = 44/210 (20%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYR 103 + GH GKST++KA++ T K A+ + Y Sbjct: 170 VVIAGHPNVGKSTLLKALT---------------TAKPEIASYPFTTRGINVGQFEDGYF 214 Query: 104 SCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNE 163 + + ++ + ++ + + +E Sbjct: 215 RYQIIDTPGLLDRPISERNEIEKQAILAL-------RYLGNLI---------IYIFDPSE 258 Query: 164 SCPQP-QTSEHL---AAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGA 219 C P + HL E L +++ NKID+ E K + + +G Sbjct: 259 HCGFPLEEQIHLFEEVHGEFKDLPFLVV-INKIDVADEENIKRLEKFVKE-------KGL 310 Query: 220 PIIPISAQLKYNIEVVCEYIVKKI-PVPPR 248 I ISA I++V E I+K + P+ + Sbjct: 311 NPIKISALKGTGIDLVKEEIIKTLRPLAEK 340 >2F7S-A nrPDB Length = 217 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 25/167 (14%), Positives = 47/167 (28%), Gaps = 9/167 (5%) Query: 81 LGYANAKIYKLDDPSCPR-PECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHD 139 +G D+ P+ + P H+ D G + Sbjct: 36 VGKTTFLYRYTDNKFNPKFITTVGIDFREKRVVYNAQGPNGSSGKAFKVHLQLWDTAGQE 95 Query: 140 ILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMK---LKHILILQNKIDLVK 196 + LL+ ++ ++ I+++ NK DL Sbjct: 96 RFRSLTTAFFRDAMGFLLMFDLTSQQSFLNVRNWMSQLQANAYCENPDIVLIGNKADLPD 155 Query: 197 ESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKI 243 + + E+ + LA G P SA N+E E ++ I Sbjct: 156 QREVNERQARELA-----DKYGIPYFETSAATGQNVEKAVETLLDLI 197 >2WJG-A nrPDB Length = 188 Score = 42.2 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 26/150 (17%), Positives = 56/150 (37%), Gaps = 15/150 (10%) Query: 116 DIPGTKGNFKLV-RHVSFVDCPGHDILMATMLNGAAVMDAAL-----LLIAGNESCPQPQ 169 + +G F+ VD PG L A ++ D + L++ ++ Sbjct: 41 TVEKKEGEFEYNGEKFKVVDLPGVYSLTANSIDEIIARDYIINEKPDLVVNIVDATALE- 99 Query: 170 TSEHLAAIEIMKL-KHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQL 228 +++M++ ++L+ NK+DL K + +++ + G ++P+SA Sbjct: 100 -RNLYLTLQLMEMGANLLLALNKMDLAKSLGIEIDVDKLEKIL------GVKVVPLSAAK 152 Query: 229 KYNIEVVCEYIVKKIPVPPRDFTSEPRLIV 258 K IE + + I + P Sbjct: 153 KMGIEELKKAISIAVKDKKTAEIKYPNFEP 182 >5LAD-A nrPDB Length = 404 Score = 41.8 bits (96), Expect = 6e-04, Method: Composition-based stats. Identities = 27/137 (19%), Positives = 56/137 (40%), Gaps = 18/137 (13%) Query: 115 TDIPGTKGNFKLVRHVSFVDCPGHDIL-------MATMLNGAAVMDAALLLIAGNESCPQ 167 TD V V+ VD PG D + + D +L+ +S P Sbjct: 45 TDPVYKSMELYPVGPVTLVDTPGLDDVGELGRLRVEKARRVFYRADCGILV---TDSEPT 101 Query: 168 PQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQ 227 P + + + M++ ++++ NKID++ E+ E++ + A ++ +SA Sbjct: 102 PYEDDVVNLFKEMEIPFVVVV-NKIDVLG-----EKAEELKGLYESRY--EAKVLLVSAL 153 Query: 228 LKYNIEVVCEYIVKKIP 244 K + + + I + +P Sbjct: 154 QKKGFDDIGKTISEILP 170 >1EK0-A nrPDB Length = 170 Score = 41.4 bits (95), Expect = 8e-04, Method: Composition-based stats. Identities = 22/122 (18%), Positives = 43/122 (35%), Gaps = 4/122 (3%) Query: 125 KLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKH 184 + D G + + AAL++ + + + + K Sbjct: 49 EHTVKFEIWDTAGQERFASLAPMYYRNAQAALVVYDVTKPQSFIKARHWVKELHEQASKD 108 Query: 185 ILILQ--NKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKK 242 I+I NKID+++E ++ + + +G SA+ N+ V I +K Sbjct: 109 IIIALVGNKIDMLQEGGERKVAREEGEKLAEE--KGLLFFETSAKTGENVNDVFLGIGEK 166 Query: 243 IP 244 IP Sbjct: 167 IP 168 >2IEZ-A nrPDB Length = 220 Score = 41.4 bits (95), Expect = 8e-04, Method: Composition-based stats. Identities = 25/167 (14%), Positives = 47/167 (28%), Gaps = 9/167 (5%) Query: 81 LGYANAKIYKLDDPSCPR-PECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHD 139 +G D+ P+ + T H+ D G + Sbjct: 22 VGKTTFLYRYTDNKFNPKFITTVGIDFREKRVVYDTQGADGASGKAFKVHLQLWDTAGLE 81 Query: 140 ILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMK---LKHILILQNKIDLVK 196 + LL+ ++ ++ I+++ NK DL Sbjct: 82 RFRSLTTAFFRDAMGFLLMFDLTSQQSFLNVRNWMSQLQANAYCENPDIVLIGNKADLPD 141 Query: 197 ESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKI 243 + + E+ + LA G P SA N+E E ++ I Sbjct: 142 QREVNERQARELAE-----KYGIPYFETSAATGQNVEKSVETLLDLI 183 >2IEY-A nrPDB Length = 195 Score = 41.4 bits (95), Expect = 8e-04, Method: Composition-based stats. Identities = 25/167 (14%), Positives = 47/167 (28%), Gaps = 9/167 (5%) Query: 81 LGYANAKIYKLDDPSCPR-PECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHD 139 +G D+ P+ + T H+ D G + Sbjct: 22 VGKTTFLYRYTDNKFNPKFITTVGIDFREKRVVYDTQGADGASGKAFKVHLQLWDTAGLE 81 Query: 140 ILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMK---LKHILILQNKIDLVK 196 + LL+ ++ ++ I+++ NK DL Sbjct: 82 RFRSLTTAFFRDAMGFLLMFDLTSQQSFLNVRNWMSQLQANAYCENPDIVLIGNKADLPD 141 Query: 197 ESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKI 243 + + E+ + LA G P SA N+E E ++ I Sbjct: 142 QREVNERQARELAE-----KYGIPYFETSAATGQNVEKSVETLLDLI 183 >3IEU-A nrPDB Length = 301 Score = 41.0 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 27/130 (20%), Positives = 48/130 (36%), Gaps = 10/130 (7%) Query: 124 FKLVRHVSFVDCPG-H----DILMATMLNGAAVMDAAL-LLIAGNESCPQPQTSEHLAAI 177 + +VD PG H + M A+ + L+I E E + Sbjct: 52 TEGAYQAIYVDTPGLHMEEKRAINRLMNKAASSSIGDVELVIFVVEGTRWTPDDEMVLNK 111 Query: 178 EIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCE 237 +++ NK+D V+E + Q LA + I+PISA+ N++ + Sbjct: 112 LREGKAPVILAVNKVDNVQEKADLLPHLQFLASQMNFL----DIVPISAETGLNVDTIAA 167 Query: 238 YIVKKIPVPP 247 + K +P Sbjct: 168 IVRKHLPEAT 177 >2WJI-A nrPDB Length = 165 Score = 40.6 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 25/131 (19%), Positives = 54/131 (41%), Gaps = 15/131 (11%) Query: 116 DIPGTKGNFKLV-RHVSFVDCPGHDILMATMLNGAAVMDAAL-----LLIAGNESCPQPQ 169 + +G F+ VD PG L A ++ D + L++ ++ Sbjct: 37 TVEKKEGEFEYNGEKFKVVDLPGVYSLTANSIDEIIARDYIINEKPDLVVNIVDATALE- 95 Query: 170 TSEHLAAIEIMKL-KHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQL 228 +++M++ ++L+ NK+DL K + +++ + G ++P+SA Sbjct: 96 -RNLYLTLQLMEMGANLLLALNKMDLAKSLGIEIDVDKLEKIL------GVKVVPLSAAK 148 Query: 229 KYNIEVVCEYI 239 K IE + + I Sbjct: 149 KMGIEELKKAI 159 >1LNZ-A nrPDB Length = 342 Score = 40.3 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 14/81 (17%), Positives = 35/81 (43%), Gaps = 9/81 (11%) Query: 177 IEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVC 236 + + + I++ NK+D+ + ++ E +++ L + P+ PISA + + + Sbjct: 270 LRLTERPQIIVA-NKMDMPEAAENLEAFKEKL-------TDDYPVFPISAVTREGLRELL 321 Query: 237 EYIVKKIP-VPPRDFTSEPRL 256 + ++ P E L Sbjct: 322 FEVANQLENTPEFPLYDEEEL 342 >1XZP-A nrPDB Length = 482 Score = 39.9 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 20/88 (22%), Positives = 37/88 (42%), Gaps = 12/88 (13%) Query: 152 MDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFV 211 D L ++ + + E +E +K K L++ NK+D+V+ K E+I + Sbjct: 324 ADIVLFVLDASSPLDE----EDRKILERIKNKRYLVVINKVDVVE----KINEEEIKNKL 375 Query: 212 QGTVAEGAPIIPISAQLKYNIEVVCEYI 239 ++ ISA +E + E I Sbjct: 376 ----GTDRHMVKISALKGEGLEKLEESI 399 >2FG5-A nrPDB Length = 192 Score = 39.5 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 21/124 (16%), Positives = 46/124 (37%), Gaps = 13/124 (10%) Query: 127 VRHVSFVDCPGHDIL--MATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKH 184 + D G + +A M + A+++ + + + ++ ++ Sbjct: 71 LHKFLIWDTAGQERFHSLAPMYYRGSAA--AVIVYDITKQDSFYTLKKWVKELKEHGPEN 128 Query: 185 ILILQ--NKIDLVKESQAKEQYEQILAFVQGTVAE-GAPIIPISAQLKYNIEVVCEYIVK 241 I++ NK DL + L + GA ++ SA+ NIE + + I + Sbjct: 129 IVMAIAGNKCDLSDIREVP------LKDAKEYAESIGAIVVETSAKNAINIEELFQGISR 182 Query: 242 KIPV 245 +IP Sbjct: 183 QIPP 186 >3J8G-X nrPDB Length = 490 Score = 38.7 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 36/210 (17%), Positives = 63/210 (30%), Gaps = 34/210 (16%) Query: 42 INIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPEC 101 I + +G GKST+ I G ER + + D P Sbjct: 203 IKLAIVGRPNVGKSTLTNRILGE---------ERVVVYDMPGTTR-----DSIYIPMERD 248 Query: 102 YRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAG 161 R + V S + L + +L+I Sbjct: 249 GREYVLIDT----AGVRKRGKITDAVEKFSVIKT----------LQAIEDANVVMLVIDA 294 Query: 162 NESCPQPQTSEHLAAIEIMKL-KHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAP 220 E + I+ + ++I+ NK D + + KEQ ++ L F G + + A Sbjct: 295 REGISDQ---DLSLLGFILNSGRSLVIVVNKWDGLS-QEVKEQVKETLDFRLGFI-DFAR 349 Query: 221 IIPISAQLKYNIEVVCEYIVKKIPVPPRDF 250 + ISA + + E + + R Sbjct: 350 VHFISALHGSGVGNLFESVREAYDSSTRRV 379 >3H2Y-A nrPDB Length = 368 Score = 37.6 bits (85), Expect = 0.011, Method: Composition-based stats. Identities = 23/149 (15%), Positives = 51/149 (34%), Gaps = 10/149 (6%) Query: 98 RPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALL 157 + E G + + + F+L + D D +LNG DA ++ Sbjct: 15 QTEDKNEVGYAPASSLEKEQVICQRCFRLKHYNEIQDVSLTDDDFLRILNGIGKSDALVV 74 Query: 158 -LIAGNE--SCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAF-VQG 213 ++ + P + +L++ NK DL+ +S ++ + + + + Sbjct: 75 KIVDIFDFNGSWLP------GLHRFVGNNKVLLVGNKADLIPKSVKHDKVKHWMRYSAKQ 128 Query: 214 TVAEGAPIIPISAQLKYNIEVVCEYIVKK 242 + + ISA I + + I Sbjct: 129 LGLKPEDVFLISAAKGQGIAELADAIEYY 157 >2UVF-A nrPDB Length = 608 Score = 37.6 bits (85), Expect = 0.012, Method: Composition-based stats. Identities = 31/197 (15%), Positives = 63/197 (31%), Gaps = 23/197 (11%) Query: 30 PLSHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIY 89 P++ + ++ +N+ G + GK+ KAI R Y + ++ Sbjct: 145 PITAKTSAKPQIVNVRDFGAIDDGKTLNTKAIQQAIDSCKPGC--RVEIPAGTYKSGALW 202 Query: 90 KLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDC-------PGHDILM 142 D + GS PD++P + + R S ++ PG Sbjct: 203 LKSDMTLNLQAGAILLGSENPDDYPAGYRLYPYST-IERPASLINAIDPNNSKPG--TFR 259 Query: 143 ATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKE 202 + G+ V+D + +T+E + + + +K V E Sbjct: 260 NIRITGSGVIDG--------NGWLRAKTAE---ITDELGRSLPQYVASKNSKVHEDGILA 308 Query: 203 QYEQILAFVQGTVAEGA 219 + + A G + A Sbjct: 309 KNQVEKAVSDGMDLKNA 325 >2WIC-A nrPDB Length = 267 Score = 37.6 bits (85), Expect = 0.012, Method: Composition-based stats. Identities = 26/218 (11%), Positives = 67/218 (30%), Gaps = 38/218 (17%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYR 103 +G IG+ GK+T+ ++G R + +T++ P Y Sbjct: 6 VGLIGNPNSGKTTLFNQLTG---ARQRVGNWAGVTVERKEGIFATTDHQVTLVDLPGTYS 62 Query: 104 SCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNE 163 S+ I H + D + ++ + Sbjct: 63 LTTISSQTSLDEQIAC---------HYIL----------------SGDADMLINVVDASN 97 Query: 164 SCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIP 223 + + + + ++ N +D+ ++ Q + + + A + G P+IP Sbjct: 98 ---LERNLYLTLQLLELGIP-CVVALNMLDIAEKQQVRIDIDALAARL------GCPVIP 147 Query: 224 ISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRS 261 + + IE + + + + P+ ++ + Sbjct: 148 LVSTRGRGIEALKIALDRHQANSDLELVHYPQPLLREA 185 >3CLV-A nrPDB Length = 208 Score = 37.2 bits (84), Expect = 0.014, Method: Composition-based stats. Identities = 28/209 (13%), Positives = 71/209 (33%), Gaps = 9/209 (4%) Query: 36 ISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPS 95 + ++++ +G + GKS++V ++ T + N + + S Sbjct: 2 MEKKSSYKTVLLGESSVGKSSIVLRLTK-DTFHENTNTTIGASFCTYVVNLNDINIKNNS 60 Query: 96 CPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAA 155 + + + T+ D G + + + A Sbjct: 61 NNEKNNNINSINDDNNVIITNQHNNYNENLCNIKFDIWDTAGQERYASIVPLYYRGATCA 120 Query: 156 LLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTV 215 +++ + S + + ++I I+++ NKID K +++ + VQ Sbjct: 121 IVVFDISNSNTLDRAKTWVNQLKISSNYIIILVANKID-------KNKFQVDILEVQKYA 173 Query: 216 AE-GAPIIPISAQLKYNIEVVCEYIVKKI 243 + I SA+ NI+ + + ++I Sbjct: 174 QDNNLLFIQTSAKTGTNIKNIFYMLAEEI 202 >4HI0-E nrPDB Length = 199 Score = 37.2 bits (84), Expect = 0.014, Method: Composition-based stats. Identities = 36/212 (16%), Positives = 69/212 (32%), Gaps = 32/212 (15%) Query: 42 INIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPEC 101 + IG G V GK+ +++A++ + + + IT + + + PR Sbjct: 2 VKIGVCGPVGSGKTALIEALTRHMSKDYDMAV---ITNDIYTKEDAEFMCKNSVMPRERI 58 Query: 102 YR-SCGSSTPDEFPTDIPGTKGNFK------LVRHVSFVDCPGHDILMATMLNGAAVMDA 154 G D + + ++ G D L AT + D Sbjct: 59 IGVETGGCPHTAIREDASMNLEAVEEMHGRFPNLELLLIESGG-DNLSATF--NPELADF 115 Query: 155 ALLLIAGNESCPQPQTSEHLAAIEIMKLKHI----LILQNKIDLVK-ESQAKEQYEQILA 209 + +I E P+ I L++ NKIDL + E+ Sbjct: 116 TIFVIDVAEGDKIPR----------KGGPGITRSDLLVINKIDLAPYVGADLKVMERDSK 165 Query: 210 FVQGTVAEGAPIIPISAQLKYNIEVVCEYIVK 241 ++G P I + + K ++ V +I + Sbjct: 166 KMRGEK----PFIFTNIRAKEGLDDVIAWIKR 193 >3GEH-A nrPDB Length = 462 Score = 37.2 bits (84), Expect = 0.015, Method: Composition-based stats. Identities = 19/101 (18%), Positives = 34/101 (33%), Gaps = 15/101 (14%) Query: 148 GAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQI 207 A D LL I E +K + ++++ NKIDLV++ Sbjct: 300 AANTADLVLLTIDAATGWTTGDQE----IYEQVKHRPLILVMNKIDLVEKQLITSLE--- 352 Query: 208 LAFVQGTVAEG-APIIPISAQLKYNIEVVCEYIVKKIPVPP 247 E I+ +A K I+ + I++ + Sbjct: 353 -------YPENITQIVHTAAAQKQGIDSLETAILEIVQTGK 386 >4DCU-A nrPDB Length = 456 Score = 37.2 bits (84), Expect = 0.016, Method: Composition-based stats. Identities = 41/202 (20%), Positives = 69/202 (34%), Gaps = 34/202 (16%) Query: 42 INIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPEC 101 I IG GKS++V A+ G ER I + D S + Sbjct: 196 IQFCLIGRPNVGKSSLVNAMLGE---------ERVIVSNVAGTTR---DAVDTSFTYNQQ 243 Query: 102 YRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAG 161 + + T + ++R + +D + +++ G Sbjct: 244 EFVIVDTAGMRKKGKVYETTEKYSVLRALKAID----------------RSEVVAVVLDG 287 Query: 162 NESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQA--KEQYEQILAFVQGTVAEGA 219 E + A E K ++I+ NK D V + ++ KE E I Q + A Sbjct: 288 EEGIIEQDKRIAGYAHEAG--KAVVIVVNKWDAVDKDESTMKEFEENIRDHFQ--FLDYA 343 Query: 220 PIIPISAQLKYNIEVVCEYIVK 241 PI+ +SA K I + I+K Sbjct: 344 PILFMSALTKKRIHTLMPAIIK 365 >2QU8-A nrPDB Length = 228 Score = 36.8 bits (83), Expect = 0.022, Method: Composition-based stats. Identities = 23/145 (15%), Positives = 42/145 (28%), Gaps = 12/145 (8%) Query: 102 YRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDI--------LMATMLNGAAVMD 153 R+ F T + +D PG + T + A ++ Sbjct: 50 SRANVDVQSYSFTTKNLYVGHFDHKLNKYQIIDTPGLLDRAFENRNTIEMTTITALAHIN 109 Query: 154 AALL-LIAGNESCPQP---QTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILA 209 +L +I +E C Q + + + K I+I NKID + ++ Sbjct: 110 GVILFIIDISEQCGLTIKEQINLFYSIKSVFSNKSIVIGFNKIDKCNMDSLSIDNKLLIK 169 Query: 210 FVQGTVAEGAPIIPISAQLKYNIEV 234 + V S +E Sbjct: 170 QILDNVKNPIKFSSFSTLTGVGVEQ 194 >5DN8-A nrPDB Length = 446 Score = 36.0 bits (81), Expect = 0.033, Method: Composition-based stats. Identities = 39/227 (17%), Positives = 69/227 (30%), Gaps = 39/227 (17%) Query: 18 QDLTTLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNI 77 +DL T + L P EVI ++ I I IG GKST++ + G Sbjct: 156 KDLMTQVLENL-PEEKEVIEKEVGIKIAMIGRPNVGKSTLINRLLG-------------- 200 Query: 78 TIKLGYANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPG 137 ++ D P R Y + + D G + K+ +V Sbjct: 201 -------EERVIVYDQPGTTRDSIYIPFARNDENYTLIDTAGIRRRAKIQDYV------- 246 Query: 138 HDILMATMLNGAAVM---DAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDL 194 + M+ M D + L+ + + +E + ++I NK D Sbjct: 247 -EKFS--MIKSLQAMHAADVVIFLLDARQGVTEQDLRLLNRIVE-AGVS-LIIAVNKWDG 301 Query: 195 VKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVK 241 + + I + I SA + + I + Sbjct: 302 LNIEERDNVRNAIDRRMPFVDFARRYFI--SALHGTGVGKLFRAIQE 346 >2KE5-A nrPDB Length = 174 Score = 36.0 bits (81), Expect = 0.038, Method: Composition-based stats. Identities = 23/120 (19%), Positives = 48/120 (40%), Gaps = 11/120 (9%) Query: 129 HVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEH-----LAAIEIMKLK 183 + +D G + A N + LL+ + E T+E E K+ Sbjct: 52 QIDILDTAGLEDYAAIRDNYFRSGEGFLLVFSITEHESFTATAEFREQILRVKAEEDKIP 111 Query: 184 HILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKI 243 +++ NK DL E + + E+ + + G + SA+ + N++ V ++++I Sbjct: 112 LLVVG-NKSDL--EERRQVPVEEARSKAEEW---GVQYVETSAKTRANVDKVFFDLMREI 165 >1UDX-A nrPDB Length = 416 Score = 35.6 bits (80), Expect = 0.047, Method: Composition-based stats. Identities = 34/199 (17%), Positives = 68/199 (34%), Gaps = 40/199 (20%) Query: 43 NIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECY 102 ++G +G+ GKS+++ A++ H K+ + E Sbjct: 159 DVGLVGYPNAGKSSLLAAMTRAHP-------------KIAPYPFTTLSPNLGVVEVSEEE 205 Query: 103 RSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGN 162 R + P G + +RH++ T + +L A + Sbjct: 206 RFTLADIPGIIEGASEGKGLGLEFLRHIA-----------RTRV-------LLYVLDAAD 247 Query: 163 ESCPQPQT--SEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAP 220 E +T E A + + L+ NK+DL++E K + + EG Sbjct: 248 EPLKTLETLRKEVGAYDPALLRRPSLVALNKVDLLEEEAVKALADALAR-------EGLA 300 Query: 221 IIPISAQLKYNIEVVCEYI 239 ++P+SA + + E + Sbjct: 301 VLPVSALTGAGLPALKEAL 319 >1WF3-A nrPDB Length = 301 Score = 35.2 bits (79), Expect = 0.061, Method: Composition-based stats. Identities = 60/365 (16%), Positives = 109/365 (29%), Gaps = 89/365 (24%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYR 103 + +G GKST++ + GV P PRP+ R Sbjct: 10 VAIVGKPNVGKSTLLNNLLGVKVA--------------------------PISPRPQTTR 43 Query: 104 SCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPG-HD------ILM-ATMLNGAAVMDAA 155 E R + FVD PG H M + A ++A Sbjct: 44 KRLRGILTEG-------------RRQIVFVDTPGLHKPMDALGEFMDQEVYEALADVNAV 90 Query: 156 LLLIAGNESCPQPQTSEHLAAIE----IMKLKHILILQNKIDLVK-ESQAKEQYEQILAF 210 + ++ P T E ++ IL++ NK+D K +A + Y ++L Sbjct: 91 VWVVD----LRHPPTPEDELVARALKPLVGKVPILLVGNKLDAAKYPEEAMKAYHELLP- 145 Query: 211 VQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCE 270 A +SA + + + ++ +P + G Sbjct: 146 -------EAEPRMLSALDERQVAELKADLLALMPE------GPFFYPEDYAKSDQTFGEW 192 Query: 271 VDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQY 330 VA + + ++ E+ P V+ E + I ++ Q Sbjct: 193 -------VAEILREEAMKRLWHEV---PYAVATKVEEVAERENGVLYIKAILYVERPSQK 242 Query: 331 AAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRR--LLGVRTEG 388 A G G K R +LG +++ +LE+ + R +R G Sbjct: 243 AIVIGEGGRKIKEIGQATRKQLEA--LLGK-----KVYLDLEVKVYPDWRKDPEALRELG 295 Query: 389 DKKAA 393 + + Sbjct: 296 YRSSV 300 >2QPT-A nrPDB Length = 550 Score = 34.9 bits (78), Expect = 0.081, Method: Composition-based stats. Identities = 29/174 (16%), Positives = 63/174 (36%), Gaps = 14/174 (8%) Query: 44 IGTIGHVAHGKSTVVKAI--SGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPEC 101 + G + GK++ ++ + V R E + + + + + + PE Sbjct: 68 VLVAGQYSTGKTSFIQYLLEQEVPGSRVGPEPTTDCFVAVMHGETEGTVPGNALVVDPEK 127 Query: 102 YRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPG-----------HDILMATMLNGAA 150 + + F + +++ +S +D PG A + A Sbjct: 128 PFRKLNPFGNTFLNRFMCAQLPNQVLESISIIDTPGILSGAKQRVSRGYDFPAVLRWFAE 187 Query: 151 VMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQY 204 +D +LL ++ + SE + A+ + K I ++ NK D+V+ Q Y Sbjct: 188 RVDLIILLFDAHKLEISDEFSEAIGALRGHEDK-IRVVLNKADMVETQQLMRVY 240 >3A1U-A nrPDB Length = 258 Score = 34.9 bits (78), Expect = 0.083, Method: Composition-based stats. Identities = 32/201 (15%), Positives = 66/201 (32%), Gaps = 42/201 (20%) Query: 42 INIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPEC 101 + + G GK+++ A++G K + P Sbjct: 6 VKVALAGCPNVGKTSLFNALTGT-------------------------KQYVANWPGVTV 40 Query: 102 YRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAG 161 + G T + ++ G + L S +D + L G D +L+ Sbjct: 41 EKKEGVFTYKGYTINLIDLPGTYSL--GYSSIDEKIARDYL---LKG--DADLVILVADS 93 Query: 162 NESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPI 221 P+ S +L + K +++ ID K++ K ++ + G P+ Sbjct: 94 ----VNPEQSLYLLLEILEMEKKVILAMTAIDEAKKTGMKIDRYELQKHL------GIPV 143 Query: 222 IPISAQLKYNIEVVCEYIVKK 242 + S+ +E + E IV+ Sbjct: 144 VFTSSVTGEGLEELKEKIVEY 164 >2X77-A nrPDB Length = 189 Score = 34.5 bits (77), Expect = 0.091, Method: Composition-based stats. Identities = 17/94 (18%), Positives = 39/94 (41%), Gaps = 5/94 (5%) Query: 153 DAALLLIAGNESCPQPQTSEHLAAI---EIMKLKHILILQNKIDLVKESQAKEQYEQILA 209 DA + ++ + L A+ + ++ +LI NK DL + E EQ+ Sbjct: 91 DAVIYVVDSTDRDRMGVAKHELYALLDEDELRKSLLLIFANKQDLPDAASEAEIAEQLG- 149 Query: 210 FVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKI 243 V + I+ S++ + +++V+++ Sbjct: 150 -VSSIMNRTWTIVKSSSKTGDGLVEGMDWLVERL 182 >3A1W-A nrPDB Length = 168 Score = 34.5 bits (77), Expect = 0.10, Method: Composition-based stats. Identities = 32/201 (15%), Positives = 66/201 (32%), Gaps = 42/201 (20%) Query: 42 INIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPEC 101 + + G GK+++ A++G K + P Sbjct: 6 VKVALAGCPNVGKTSLFNALTGT-------------------------KQYVANWPGVTV 40 Query: 102 YRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAG 161 + G T + ++ G + L S +D + L G D +L+ Sbjct: 41 EKKEGVFTYKGYTINLIDLPGTYSL--GYSSIDEKIARDYL---LKG--DADLVILVADS 93 Query: 162 NESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPI 221 P+ S +L + K +++ ID K++ K ++ + G P+ Sbjct: 94 ----VNPEQSLYLLLEILEMEKKVILAMTAIDEAKKTGMKIDRYELQKHL------GIPV 143 Query: 222 IPISAQLKYNIEVVCEYIVKK 242 + S+ +E + E IV+ Sbjct: 144 VFTSSVTGEGLEELKEKIVEY 164 >5CM8-B nrPDB Length = 203 Score = 34.5 bits (77), Expect = 0.11, Method: Composition-based stats. Identities = 21/119 (17%), Positives = 43/119 (36%), Gaps = 10/119 (8%) Query: 129 HVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEH----LAAIEIMKLKH 184 + +D G + A N + L + + + T E L + Sbjct: 62 QIDILDTAGQEDYAAIRDNYFRSGEGFLCVFSITDDESFQATQEFREQILRVKNDESIPF 121 Query: 185 ILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKI 243 +L+ NK DL + + Q+ A P + SA+ + N++ V ++++I Sbjct: 122 LLVG-NKCDLNDKRKVPLSECQLRA-----QQWAVPYVETSAKTRENVDKVFFDLMREI 174 >4R98-A nrPDB Length = 271 Score = 33.7 bits (75), Expect = 0.16, Method: Composition-based stats. Identities = 26/199 (13%), Positives = 63/199 (31%), Gaps = 38/199 (19%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYR 103 IG IG+ GK+T+ ++G R + +T++ P Y Sbjct: 6 IGLIGNPNSGKTTLFNQLTG---SRQRVGNWAGVTVERKEGQFSTTDHQVTLVDLPGTYS 62 Query: 104 SCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNE 163 S+ I H + D + ++ + Sbjct: 63 LTTISSQTSLDEQIAC---------HYIL----------------SGDADLLINVVDASN 97 Query: 164 SCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIP 223 + + + + ++ N +D+ ++ + + + + A + G P+IP Sbjct: 98 ---LERNLYLTLQLLELGIP-CIVALNMLDIAEKQNIRIEIDALSARL------GCPVIP 147 Query: 224 ISAQLKYNIEVVCEYIVKK 242 + A N++ V + + + Sbjct: 148 LVATDTKNVQFVLKLAIDR 166 >3IBY-A nrPDB Length = 256 Score = 33.7 bits (75), Expect = 0.17, Method: Composition-based stats. Identities = 24/140 (17%), Positives = 48/140 (34%), Gaps = 27/140 (19%) Query: 116 DIPGTKGNFKLVRH-VSFVDCPGHDILMATM--------LNGAAVMD----AALLLIAGN 162 + G F L H + D PG L+A + +V+D + +I Sbjct: 35 TVEKKTGEFLLGEHLIEITDLPGVYSLVANAEGISQDEQIAAQSVIDLEYDCIINVIDAC 94 Query: 163 ESCPQPQTSEHLAAIEIMKL--KHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAP 220 HL + K +++ N +D+ + E++ + + G Sbjct: 95 ------HLERHLYLTSQLFELGKPVVVALNMMDIAEHRGISIDTEKLESLL------GCS 142 Query: 221 IIPISAQLKYNIEVVCEYIV 240 +IPI A I + + ++ Sbjct: 143 VIPIQAHKNIGIPALQQSLL 162 >1YR7-A nrPDB Length = 262 Score = 33.3 bits (74), Expect = 0.26, Method: Composition-based stats. Identities = 23/180 (12%), Positives = 51/180 (28%), Gaps = 20/180 (11%) Query: 44 IGTIGHVAHGKSTVVK----------AISGVHTVRFKNELERNITIKLGYANAKIYKLDD 93 + +G GK+T+ ++ V+ EL +I + + Sbjct: 17 VVFVGTAGSGKTTLTGEFGRYLEDNYKVAYVNLDTGVKELPYEPSIDVR--EFVTVEEIM 74 Query: 94 PSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMD 153 P E + + +D PG G +M+ Sbjct: 75 REGYGPNGAIVESYDRLMEKFNEYLNKILRLEKENDYVLIDTPGQMETFLFHEFGVRLME 134 Query: 154 AAL--LLIAGNES--CPQPQ----TSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYE 205 L++ ++ +P I++ + NK+DL+ E + + + Sbjct: 135 NLPYPLVVYISDPEILKKPNDYCFVRFFALLIDLRLGATTIPALNKVDLLSEEEKERHRK 194 >5ZZM-A nrPDB Length = 426 Score = 32.9 bits (73), Expect = 0.28, Method: Composition-based stats. Identities = 34/219 (15%), Positives = 69/219 (31%), Gaps = 44/219 (20%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYR 103 + +G+ GKST+ I+ YA +++ DP+ R Sbjct: 200 VSLVGYTNAGKSTLFNRITEARV----------------YAADQLFATLDPTLRR----- 238 Query: 104 SCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNE 163 D T + T G + + H AT+ L +I + Sbjct: 239 ---IDVADVGETVLADTVGFIRHLPHDLV------AAFKATLQE-TRQATLLLHVIDAAD 288 Query: 164 SCPQPQTSEHLAAIEIMKLKHI--LILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPI 221 Q +E + I L++ NKID++++ + + ++ Sbjct: 289 VRVQENIEAVNTVLEEIDAHEIPTLLVMNKIDMLEDFEPRIDRDEENK---------PNR 339 Query: 222 IPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIR 260 + +SAQ I + + + +++ RL Sbjct: 340 VWLSAQTGAGIPQLFQALTERLSGEVA--QHTLRLPPQE 376 >2HF8-A nrPDB Length = 226 Score = 32.9 bits (73), Expect = 0.31, Method: Composition-based stats. Identities = 30/226 (13%), Positives = 75/226 (33%), Gaps = 32/226 (14%) Query: 27 KLTPLSHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANA 86 +L + +++++ + +G + GK+ ++ +L N+ K A Sbjct: 24 RLADKNRKLLNKHGVVAFDFMGAIGSGKTLLI------------EKLIDNLKDKYKIACI 71 Query: 87 KIYKLDDPSCPRPECYRSCGSSTPDEFPTDI-PGTKGNFKLVRHVSFVDCPGHDILMATM 145 + R E + + + G+ ++ +D + + + Sbjct: 72 AGDVIAKFDAERMEKHGAKVVPLNTGKECHLDAHLVGHALEDLNLDEIDL----LFIENV 127 Query: 146 LNGAAVMDA------ALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQ 199 N D +++I+ E +H ++ LI+ NKIDL Sbjct: 128 GNLICPADFDLGTHKRIVVISTTEGDD--TIEKHPGIMKTAD----LIVINKIDLADA-- 179 Query: 200 AKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPV 245 +++ + A ++ +S + + V E+I K + Sbjct: 180 VGADIKKMENDAKRINP-DAEVVLLSLKTMEGFDKVLEFIEKSVKE 224 >2YV5-A nrPDB Length = 302 Score = 32.6 bits (72), Expect = 0.43, Method: Composition-based stats. Identities = 15/70 (21%), Positives = 35/70 (50%), Gaps = 5/70 (7%) Query: 174 LAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIE 233 L E K++ +++ NKIDL +E+ +++ ++ G ++ +SA+ I+ Sbjct: 103 LVVYEYFKVEPVIVF-NKIDL----LNEEEKKELERWISIYRDAGYDVLKVSAKTGEGID 157 Query: 234 VVCEYIVKKI 243 + +Y+ I Sbjct: 158 ELVDYLEGFI 167 >5UHV-A nrPDB Length = 166 Score = 31.8 bits (70), Expect = 0.63, Method: Composition-based stats. Identities = 21/115 (18%), Positives = 43/115 (37%), Gaps = 9/115 (7%) Query: 132 FVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQT---SEHLAAIEIMKLKHILIL 188 +D G + A + L + A N S E + ++ ++++ Sbjct: 55 ILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLV 114 Query: 189 QNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKI 243 NK DL + +Q ++ + G P I SA+ + +E +V++I Sbjct: 115 GNKCDLPTRTVDTKQAHELAK------SYGIPFIETSAKTRQGVEDAFYTLVREI 163 >3CON-A nrPDB Length = 190 Score = 31.8 bits (70), Expect = 0.63, Method: Composition-based stats. Identities = 21/115 (18%), Positives = 43/115 (37%), Gaps = 9/115 (7%) Query: 132 FVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQT---SEHLAAIEIMKLKHILIL 188 +D G + A + L + A N S E + ++ ++++ Sbjct: 73 ILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLV 132 Query: 189 QNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKI 243 NK DL + +Q ++ + G P I SA+ + +E +V++I Sbjct: 133 GNKCDLPTRTVDTKQAHELAK------SYGIPFIETSAKTRQGVEDAFYTLVREI 181 >3ZYS-B nrPDB Length = 662 Score = 31.8 bits (70), Expect = 0.64, Method: Composition-based stats. Identities = 33/203 (16%), Positives = 71/203 (34%), Gaps = 42/203 (20%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKN---------ELERNITIKL--GYANAKIYKLD 92 I IG + GKS+V++A+SGV R +L++ + G + + Y+++ Sbjct: 73 IAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKLVNEDKWRGKVSYQDYEIE 132 Query: 93 DPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKL----VRHVSFVDCPGHDILMATMLNG 148 E + + I ++ V ++ +D PG + + G Sbjct: 133 ISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPG----ITRVAVG 188 Query: 149 AAVMD------------------AALLLIAGNESCPQPQTSEHLAAIEIMKLK--HILIL 188 D +L+++ N T+E L+ + + + + + Sbjct: 189 NQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIA---TTEALSMAQEVDPEGDRTIGI 245 Query: 189 QNKIDLVKESQAKEQYEQILAFV 211 K DLV + + + + V Sbjct: 246 LTKPDLVDKGTEDKVVDVVRNLV 268 >5GTM-A nrPDB Length = 601 Score = 31.8 bits (70), Expect = 0.71, Method: Composition-based stats. Identities = 33/203 (16%), Positives = 71/203 (34%), Gaps = 42/203 (20%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKN---------ELERNITIKL--GYANAKIYKLD 92 I IG + GKS+V++A+SGV R +L++ + G + + Y+++ Sbjct: 41 IAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKLVNEDKWRGKVSYQDYEIE 100 Query: 93 DPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKL----VRHVSFVDCPGHDILMATMLNG 148 E + + I ++ V ++ +D PG + + G Sbjct: 101 ISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPG----ITRVAVG 156 Query: 149 AAVMD------------------AALLLIAGNESCPQPQTSEHLAAIEIMKLK--HILIL 188 D +L+++ N T+E L+ + + + + + Sbjct: 157 NQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIA---TTEALSMAQEVDPEGDRTIGI 213 Query: 189 QNKIDLVKESQAKEQYEQILAFV 211 K DLV + + + + V Sbjct: 214 LTKPDLVDKGTEDKVVDVVRNLV 236 >2GAO-A nrPDB Length = 208 Score = 31.4 bits (69), Expect = 0.95, Method: Composition-based stats. Identities = 23/117 (19%), Positives = 43/117 (36%), Gaps = 3/117 (2%) Query: 114 PTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEH 173 PT P ++ + D GH+ N ++ + L+ + ++ Sbjct: 65 PTLHPTSEELTIAGMTFTTFDLGGHEQARRVWKNYLPAINGIVFLVDCADHSRLVESKVE 124 Query: 174 LAAI---EIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQ 227 L A+ E + ILIL NKID ++ E + Q T + ++A+ Sbjct: 125 LNALMTDETISNVPILILGNKIDRTDAISEEKLREIFGLYGQTTGKGNVTLKELNAR 181 >4CSU-9 nrPDB Length = 390 Score = 31.4 bits (69), Expect = 0.97, Method: Composition-based stats. Identities = 34/216 (15%), Positives = 74/216 (34%), Gaps = 32/216 (14%) Query: 43 NIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECY 102 ++G +G GKST ++A+S + P Sbjct: 161 DVGMLGMPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVVRMDNEKSFVVADIPGLIEG 220 Query: 103 RSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGN 162 + G+ F + + ++ H+ +D ++G ++ A ++I+ Sbjct: 221 AAEGAGLGIRFLKHLERCR----VLLHLIDIDP----------IDGTDPVENARIIIS-- 264 Query: 163 ESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPII 222 E + + K ++ NKIDL+ + +A+E+ + I + Sbjct: 265 ---------ELEKYSQDLATKPRWLVFNKIDLLDKVEAEEKAKAIAEAL----GWEDKYY 311 Query: 223 PISAQLKYNIEVVCEYIVKKI---PVPPRDFTSEPR 255 ISA ++ +C ++ I PV + +P Sbjct: 312 LISAASGLGVKDLCWDVMTFIIENPVVQAEEAKQPE 347 >1F6B-A nrPDB Length = 198 Score = 31.4 bits (69), Expect = 0.98, Method: Composition-based stats. Identities = 23/109 (21%), Positives = 44/109 (40%), Gaps = 4/109 (3%) Query: 114 PTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEH 173 PT P ++ + D GH N ++ + L+ + ++ E Sbjct: 55 PTLHPTSEELTIAGMTFTTFDLGGHIQARRVWKNYLPAINGIVFLVDCADHERLLESKEE 114 Query: 174 LAAI---EIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGA 219 L ++ E + ILIL NKID E+ ++E+ ++ T +G+ Sbjct: 115 LDSLMTDETIANVPILILGNKIDRP-EAISEERLREMFGLYGQTTGKGS 162 >4V7F-o nrPDB Length = 647 Score = 31.0 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 25/127 (19%), Positives = 49/127 (38%), Gaps = 14/127 (11%) Query: 129 HVSFVDCPGHDIL---------MATMLNGAAVMDAALLLIAGNESCP---QPQTSEHLAA 176 +D PG M ++ A + L + +E C + Q + Sbjct: 215 RFQAIDTPGILDRPTEEMNNIEMQSIYAIAHLRSCVLYFMDLSEQCGFTIEAQVKLFHSI 274 Query: 177 IEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVC 236 + K ++++ NK D+++ E+ Q+L V+ G I+ S QL+ N+ V Sbjct: 275 KPLFANKSVMVVINKTDIIRPEDLDEERAQLLESVKEV--PGVEIMTSSCQLEENVMEVR 332 Query: 237 EYIVKKI 243 +K+ Sbjct: 333 NKACEKL 339 >3LRP-A nrPDB Length = 181 Score = 31.0 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 15/61 (24%), Positives = 25/61 (40%), Gaps = 3/61 (4%) Query: 150 AVMDAALLLIAGNESCPQPQTSEHLAAI---EIMKLKHILILQNKIDLVKESQAKEQYEQ 206 + D + ++ N+ E L + E +K IL+ NK DL A E E+ Sbjct: 83 SNTDGLIFVVDSNDRERIDDAREELHRMINEEELKDAIILVFANKQDLPNAMSAAEVTEK 142 Query: 207 I 207 + Sbjct: 143 L 143 >4MKI-B nrPDB Length = 298 Score = 31.0 bits (68), Expect = 1.2, Method: Composition-based stats. Identities = 11/36 (30%), Positives = 18/36 (50%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITI 79 +G IGH GKST+++ ++G+ I I Sbjct: 40 VGIIGHTGSGKSTLIQQLNGLLKPSKGKIYINGIDI 75 >4HZU-A nrPDB Length = 279 Score = 30.6 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 24/175 (13%), Positives = 55/175 (31%), Gaps = 14/175 (8%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYR 103 + +GH GKST+ K++ G+ + IT+ ++ + Sbjct: 36 LAIVGHNGSGKSTLAKSLDGLLPFTQGSVTVGGITLTPETVWQVREQIGMIFQNPDNQFV 95 Query: 104 SCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILM-------------ATMLNGAA 150 F + + + R + + G L G Sbjct: 96 GATVEDDVAFGLENRQISRDEMVPRVQAALAQVGMTSFAQREPSSLSGGQKQRVALAGIV 155 Query: 151 VMDAALLLIAGNESCPQPQTS-EHLAAIEIMKLKHILILQNKIDLVKESQAKEQY 204 + +L++ S PQ E LA + ++ + L + + + E+ + ++ Sbjct: 156 AIAPKILILDEATSMLDPQGRIEMLAIVRQLRQQQNLTVISITHDIDEAASADRV 210 >2DYK-A nrPDB Length = 161 Score = 30.6 bits (67), Expect = 1.5, Method: Composition-based stats. Identities = 21/96 (21%), Positives = 38/96 (39%), Gaps = 11/96 (11%) Query: 150 AVMDAALLLIAGNESCPQPQT-SEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQIL 208 A+ DA ++L A + Q E + IL+ K+D ++E L Sbjct: 76 ALEDAEVVLFAVDGRAELTQADYEVAEYLRRKGKPVILVA-TKVDDP-------KHELYL 127 Query: 209 AFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIP 244 + G IP S++ +E + E I +++P Sbjct: 128 GPLYGLGFGDP--IPTSSEHARGLEELLEAIWERLP 161 >4LR2-A nrPDB Length = 401 Score = 30.6 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 7/29 (24%), Positives = 16/29 (55%) Query: 21 TTLDVTKLTPLSHEVISRQATINIGTIGH 49 +T+++ + P+ ++ + N GT GH Sbjct: 348 STINIVDIYPMMCHILGLKPHPNNGTFGH 376 >5M04-A nrPDB Length = 360 Score = 30.6 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 31/201 (15%), Positives = 69/201 (34%), Gaps = 29/201 (14%) Query: 43 NIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECY 102 ++G +G GKST ++A+S + P Sbjct: 181 DVGMLGMPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVVRMDNEKSFVVADIPGLIEG 240 Query: 103 RSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGN 162 + G+ F + + ++ H+ +D ++G ++ A ++I+ Sbjct: 241 AAEGAGLGIRFLKHLERCR----VLLHLIDIDP----------IDGTDPVENARIIIS-- 284 Query: 163 ESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPII 222 E + + K ++ NKIDL+ + +A+E+ + I + Sbjct: 285 ---------ELEKYSQDLATKPRWLVFNKIDLLDKVEAEEKAKAIAEAL----GWEDKYY 331 Query: 223 PISAQLKYNIEVVCEYIVKKI 243 ISA ++ +C ++ I Sbjct: 332 LISAASGLGVKDLCWDVMTFI 352 >6OIJ-A nrPDB Length = 353 Score = 30.6 bits (67), Expect = 1.7, Method: Composition-based stats. Identities = 15/66 (22%), Positives = 30/66 (45%), Gaps = 2/66 (3%) Query: 15 LSRQDLTTLDVTKLTPLSHEVISRQA--TINIGTIGHVAHGKSTVVKAISGVHTVRFKNE 72 LS +D ++ +K+ + +A + + +G GKST +K + +H + E Sbjct: 5 LSAEDKAAVERSKMIDRNLREDGEKARRELKLLLLGTGESGKSTFIKQMRIIHGAGYSEE 64 Query: 73 LERNIT 78 +R T Sbjct: 65 DKRGFT 70 >6FNP-B nrPDB Length = 300 Score = 29.9 bits (65), Expect = 2.6, Method: Composition-based stats. Identities = 33/240 (13%), Positives = 81/240 (33%), Gaps = 20/240 (8%) Query: 45 GTIGHVAHGKSTVVKAISGVHTVRFKNELERNIT-IKLGYANAKIYKLDDPSCPRPECYR 103 IGH GKSTV K I+G+ ++ + +KLG + + + Sbjct: 55 ALIGHNGSGKSTVSKLINGLLAPDDLDKSSITVDGVKLGADTVWEVREKVGIVFQNPDNQ 114 Query: 104 SCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNE 163 G++ D+ + + + +A + + D A Sbjct: 115 FVGATVSDDVAFGLENRAVPRPEMLKI-----------VAQAVADVGMADYA----DSEP 159 Query: 164 SCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIP 223 S + +A I+ +K +I+ ++ + + + KEQ ++ ++ I Sbjct: 160 SNLSGGQKQRVAIAGILAVKPQVIILDESTSMLDPEGKEQILDLVRKIKEDNNLTVISIT 219 Query: 224 ISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGC----EVDDLKGGVA 279 + + V ++ + P++ +++ ++ P ++ +G V Sbjct: 220 HDLEEAAGADQVLVLDDGQLLDQGKPEEIFPKVEMLKRIGLDIPFVYRLKQLLKERGIVL 279 >2YKR-W nrPDB Length = 350 Score = 29.9 bits (65), Expect = 2.8, Method: Composition-based stats. Identities = 19/106 (17%), Positives = 45/106 (42%), Gaps = 5/106 (4%) Query: 140 ILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQ 199 + AA +D +++ A +L A E ++++ I++ NKIDL+ + Sbjct: 111 DFYDGVKPIAANIDQIVIVSAILPELSLNIIDRYLVACETLQIEPIIV-LNKIDLLDDEG 169 Query: 200 AKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPV 245 EQ+ G ++ +S+ + ++ + E + +I + Sbjct: 170 MAFVNEQM----DIYRNIGYRVLMVSSHTQDGLKPLEEALTGRISI 211 >5NO4-Z nrPDB Length = 313 Score = 29.9 bits (65), Expect = 2.8, Method: Composition-based stats. Identities = 19/106 (17%), Positives = 45/106 (42%), Gaps = 5/106 (4%) Query: 140 ILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQ 199 + AA +D +++ A +L A E ++++ I++ NKIDL+ + Sbjct: 78 DFYDGVKPIAANIDQIVIVSAILPELSLNIIDRYLVACETLQIEPIIV-LNKIDLLDDEG 136 Query: 200 AKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPV 245 EQ+ G ++ +S+ + ++ + E + +I + Sbjct: 137 MAFVNEQM----DIYRNIGYRVLMVSSHTQDGLKPLEEALTGRISI 178 >3D3R-A nrPDB Length = 103 Score = 29.5 bits (64), Expect = 3.1, Method: Composition-based stats. Identities = 10/31 (32%), Positives = 18/31 (58%) Query: 184 HILILQNKIDLVKESQAKEQYEQILAFVQGT 214 HI + NKID Q+ E Y++I++ ++ Sbjct: 69 HIGFVMNKIDRNDALQSLELYQEIVSKLENE 99 >4CPD-A nrPDB Length = 347 Score = 29.5 bits (64), Expect = 3.2, Method: Composition-based stats. Identities = 15/71 (21%), Positives = 30/71 (42%) Query: 279 AGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIG 338 A G +++G L+ G + V ++ SKI+++ L+ AA G I Sbjct: 157 AYGGLIQGQLRPGDSVAVIGAGPVGLMAIEVAQVLGASKILAIDRIPERLERAASLGAIP 216 Query: 339 VGTKIDPTLCR 349 + + + + R Sbjct: 217 INAEQENPVRR 227 >4WA7-A nrPDB Length = 170 Score = 29.5 bits (64), Expect = 3.3, Method: Composition-based stats. Identities = 22/119 (18%), Positives = 47/119 (39%), Gaps = 17/119 (14%) Query: 132 FVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSE--HLAAIEIMKLKH----- 184 +D G + A + L + A N ++ E H +I ++K Sbjct: 56 ILDTAGLEEYSAMRDQYMRTGEGFLCVFAIN----NTKSFEDIHHYREQIKRVKDSEDVP 111 Query: 185 ILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKI 243 ++++ NK DL + +Q + + + G P I SA+ + ++ +V++I Sbjct: 112 MVLVGNKCDLPSRTVDTKQAQDLAR------SYGIPFIETSAKTRQGVDDAFYTLVREI 164 >4P4S-B nrPDB Length = 346 Score = 29.5 bits (64), Expect = 3.4, Method: Composition-based stats. Identities = 33/200 (16%), Positives = 69/200 (34%), Gaps = 36/200 (18%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKN---------ELERNITIKL--GYANAKIYKLD 92 I IG + GKS+V++A+SGV R +L++ + G + + Y+++ Sbjct: 31 IAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKLVNEDKWRGKVSYQDYEIE 90 Query: 93 DPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKL----VRHVSFVDCPGHDILMATMLNG 148 E + + I ++ V ++ +D PG + + G Sbjct: 91 ISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPG----ITRVAVG 146 Query: 149 AAVMDAALLLIAGNESCPQPQ---------------TSEHLAAIEIMKLK--HILILQNK 191 D + + Q Q T+E L+ + + + + + K Sbjct: 147 NQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTK 206 Query: 192 IDLVKESQAKEQYEQILAFV 211 DLV + + + + V Sbjct: 207 PDLVDKGTEDKVVDVVRNLV 226 >2BCJ-Q nrPDB Length = 353 Score = 29.5 bits (64), Expect = 3.5, Method: Composition-based stats. Identities = 14/66 (21%), Positives = 31/66 (46%), Gaps = 2/66 (3%) Query: 15 LSRQDLTTLDVTKLTPLS--HEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNE 72 LS +D ++ +K+ + + + + + +G GKST +K + +H + +E Sbjct: 5 LSAEDKAAVERSKMIDRNLREDGERSRRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDE 64 Query: 73 LERNIT 78 +R T Sbjct: 65 DKRGFT 70 >6FT6-s nrPDB Length = 520 Score = 29.5 bits (64), Expect = 3.5, Method: Composition-based stats. Identities = 13/78 (16%), Positives = 27/78 (34%), Gaps = 9/78 (11%) Query: 153 DAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQ 212 D L ++ + A ++ K ++++ NK+DL+ +L Sbjct: 177 DVILYVLDARDPESTRSRKVEEAVLQSQG-KRLILILNKVDLIPP--------HVLEQWL 227 Query: 213 GTVAEGAPIIPISAQLKY 230 + P IP+ A Sbjct: 228 NYLKSSFPTIPLRASSGA 245 >3NXS-A nrPDB Length = 329 Score = 29.1 bits (63), Expect = 3.9, Method: Composition-based stats. Identities = 10/60 (16%), Positives = 26/60 (43%), Gaps = 4/60 (6%) Query: 186 LILQNKIDLVKESQAKEQYEQILAFVQGTVAEGA----PIIPISAQLKYNIEVVCEYIVK 241 +I+ NK D +AK ++ ++ + P++ +SA + + E +++ Sbjct: 199 VIVVNKADGEHAVEAKAAARELSGAIRLIYPRESLWRPPVLTMSAVEGTGLPELWETVLR 258 >4P4S-A nrPDB Length = 303 Score = 29.1 bits (63), Expect = 4.0, Method: Composition-based stats. Identities = 33/200 (16%), Positives = 69/200 (34%), Gaps = 36/200 (18%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKN---------ELERNITIKL--GYANAKIYKLD 92 I IG + GKS+V++A+SGV R +L++ + G + + Y+++ Sbjct: 16 IAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKLVNEDKWRGKVSYQDYEIE 75 Query: 93 DPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKL----VRHVSFVDCPGHDILMATMLNG 148 E + + I ++ V ++ +D PG + + G Sbjct: 76 ISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPG----ITRVAVG 131 Query: 149 AAVMDAALLLIAGNESCPQPQ---------------TSEHLAAIEIMKLK--HILILQNK 191 D + + Q Q T+E L+ + + + + + K Sbjct: 132 NQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTK 191 Query: 192 IDLVKESQAKEQYEQILAFV 211 DLV + + + + V Sbjct: 192 PDLVDKGTEDKVVDVVRNLV 211 >5XNM-B nrPDB Length = 507 Score = 29.1 bits (63), Expect = 4.7, Method: Composition-based stats. Identities = 14/68 (20%), Positives = 25/68 (36%) Query: 15 LSRQDLTTLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELE 74 L R L + V + +P + + GH+ HG T+ + + ++E Sbjct: 432 LDRATLKSDGVFRSSPRGWFTFGHASFALLFFFGHIWHGARTLFRDLFAGIDPDLDAQVE 491 Query: 75 RNITIKLG 82 KLG Sbjct: 492 FGAFQKLG 499 >3TK1-A nrPDB Length = 330 Score = 29.1 bits (63), Expect = 4.9, Method: Composition-based stats. Identities = 9/60 (15%), Positives = 26/60 (43%), Gaps = 4/60 (6%) Query: 186 LILQNKIDLVKESQAKEQYEQILAFVQGTVAEGA----PIIPISAQLKYNIEVVCEYIVK 241 +++ NK D +A++ ++ ++ P++ +SA + + E ++K Sbjct: 198 IVVVNKADGEHAVEARKAARELAGAMRLIYPRETLWRPPVLTMSALEGTGVAELWETVLK 257 >1VIA-A nrPDB Length = 175 Score = 29.1 bits (63), Expect = 4.9, Method: Composition-based stats. Identities = 9/19 (47%), Positives = 13/19 (68%) Query: 43 NIGTIGHVAHGKSTVVKAI 61 NI IG + GKST+ +A+ Sbjct: 6 NIVFIGFMGSGKSTLARAL 24 >6HA8-V nrPDB Length = 548 Score = 28.3 bits (61), Expect = 7.8, Method: Composition-based stats. Identities = 28/129 (21%), Positives = 46/129 (35%), Gaps = 17/129 (13%) Query: 24 DVTKLTPLSHEVISRQA--TIN--------IGTIGHVAHGKSTVVKAISGVHTVRFKNEL 73 ++ LT +S+EV + +N IG IG GKST++ I L Sbjct: 9 EIVTLTNVSYEVKDQTVFKHVNASVQQGDIIGIIGKNGAGKSTLLHLIHNDLAPAQGQIL 68 Query: 74 ERNITIKLGYANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVS-- 131 ++I + L Y D + P + +F G K +L + +S Sbjct: 69 RKDIKLALVEQETAAYSFADQT-PAEKKLLEKWHVPLRDFHQLSGGEKLKARLAKGLSED 127 Query: 132 ----FVDCP 136 +D P Sbjct: 128 ADLLLLDQP 136 >5NKM-B nrPDB Length = 317 Score = 28.3 bits (61), Expect = 8.0, Method: Composition-based stats. Identities = 10/51 (19%), Positives = 26/51 (50%), Gaps = 1/51 (1%) Query: 24 DVTKLTPLSHEVISRQATINIGT-IGHVAHGKSTVVKAISGVHTVRFKNEL 73 D +++ ++++ N+ + IG GKST++ ++G ++ + E Sbjct: 10 DFGEISDAISDLLTSSPNFNVISAIGPQGAGKSTLLSMLAGNNSRQMYREY 60 >3MD0-A nrPDB Length = 355 Score = 27.9 bits (60), Expect = 8.6, Method: Composition-based stats. Identities = 28/205 (13%), Positives = 72/205 (35%), Gaps = 13/205 (6%) Query: 44 IGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYR 103 +G G GKST ++A+ + R + + ++ + R Sbjct: 82 VGITGVPGVGKSTAIEAL----GMHLIERGHRVAVLAVDPSSTRTGGSILGDKTRMARLA 137 Query: 104 SCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALL-LIAGN 162 ++ PT V ++ G D+++ + G + A+ ++ Sbjct: 138 VHPNAYIRPSPTSGTLGGVTRATRETVVLLEAAGFDVILIETV-GVGQSEVAVANMVDTF 196 Query: 163 ESCPQPQTSEHLAAIEIMKLKHI--LILQNKIDLVKESQAKEQYEQILAFVQGTVAEGA- 219 +T + L I+ + + +++ NK D +A+ ++ A ++ A Sbjct: 197 VLLTLARTGDQLQGIKK-GVLELADIVVVNKADGEHHKEARLAARELSAAIRLIYPREAL 255 Query: 220 ---PIIPISAQLKYNIEVVCEYIVK 241 P++ +SA + + + + + Sbjct: 256 WRPPVLTMSAVEGRGLAELWDTVER 280 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.116 0.292 Lambda K H 0.267 0.0350 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 14,723,575 Number of Sequences: 36641 Number of extensions: 527469 Number of successful extensions: 2441 Number of sequences better than 10.0: 171 Number of HSP's better than 10.0 without gapping: 144 Number of HSP's successfully gapped in prelim test: 104 Number of HSP's that attempted gapping in prelim test: 1832 Number of HSP's gapped (non-prelim): 346 length of query: 472 length of database: 10,336,785 effective HSP length: 101 effective length of query: 371 effective length of database: 6,636,044 effective search space: 2461972324 effective search space used: 2461972324 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 60 (27.9 bits)