BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P40968 (455 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 6J6H-n nrPDB 946 0.0 3JB9-g nrPDB 303 1e-82 6QDV-o nrPDB 282 3e-76 5YZG-W nrPDB 282 3e-76 6QX9-5O nrPDB 96 3e-20 5M25-A nrPDB 90 2e-18 2H9P-A nrPDB 89 3e-18 1VYH-C nrPDB 70 1e-12 6HHQ-h nrPDB 70 2e-12 2YNP-A nrPDB 68 1e-11 3MKQ-A nrPDB 67 2e-11 6F3T-A nrPDB 67 2e-11 5XYI-g nrPDB 67 2e-11 6MZM-G nrPDB 66 4e-11 5I2T-A nrPDB 64 1e-10 5WLC-LO nrPDB 64 1e-10 3FM0-A nrPDB 64 1e-10 6HQA-B nrPDB 64 1e-10 4LG8-A nrPDB 64 2e-10 5Z56-q nrPDB 63 2e-10 6N9G-C nrPDB 62 7e-10 4V8M-A7 nrPDB 61 1e-09 5NZU-C nrPDB 60 2e-09 3JB9-L nrPDB 60 2e-09 5NNZ-B nrPDB 60 3e-09 5OPT-p nrPDB 59 4e-09 3DM0-A nrPDB 59 6e-09 5OV3-A nrPDB 59 6e-09 5LCW-Q nrPDB 59 6e-09 3ODT-A nrPDB 59 6e-09 4N14-A nrPDB 58 7e-09 4GGA-A nrPDB 58 7e-09 5G04-R nrPDB 58 9e-09 5K1B-B nrPDB 57 1e-08 4V7E-Bg nrPDB 57 1e-08 6EMK-B nrPDB 57 2e-08 5Y88-O nrPDB 56 3e-08 5UZ7-B nrPDB 56 4e-08 6ID0-T nrPDB 55 4e-08 6QX9-4B nrPDB 55 5e-08 6G51-g nrPDB 55 9e-08 4V6W-Ag nrPDB 55 9e-08 5WYK-BB nrPDB 53 3e-07 5MWJ-A nrPDB 53 3e-07 5FL8-q nrPDB 53 3e-07 5L9T-R nrPDB 52 4e-07 5MZH-A nrPDB 52 5e-07 3JAP-g nrPDB 52 6e-07 4BTS-AR nrPDB 51 1e-06 5FVM-C nrPDB 51 1e-06 6BX3-A nrPDB 51 1e-06 5OQL-J nrPDB 51 1e-06 6Q8F-A nrPDB 50 2e-06 1NR0-A nrPDB 50 2e-06 6GMH-W nrPDB 49 3e-06 5GAN-H nrPDB 49 4e-06 5WJC-A nrPDB 49 7e-06 5WBU-D nrPDB 48 7e-06 3JZG-A nrPDB 48 7e-06 2HES-X nrPDB 48 8e-06 4A11-B nrPDB 48 1e-05 6EOJ-D nrPDB 47 1e-05 4G56-B nrPDB 47 2e-05 6E29-D nrPDB 46 4e-05 3C9C-A nrPDB 45 6e-05 5WYJ-BC nrPDB 45 7e-05 5FA5-B nrPDB 45 1e-04 5OQL-d nrPDB 44 1e-04 5BJS-A nrPDB 44 1e-04 3ACP-A nrPDB 44 1e-04 5OQL-L nrPDB 44 1e-04 3CFV-B nrPDB 43 2e-04 5Y1U-A nrPDB 43 3e-04 5K0Y-T nrPDB 43 3e-04 4OWR-A nrPDB 42 5e-04 4XYI-A nrPDB 42 5e-04 4XFV-A nrPDB 42 7e-04 4BH6-A nrPDB 41 0.001 6CHG-A nrPDB 41 0.001 6ELZ-p nrPDB 40 0.001 5A31-R nrPDB 40 0.001 4AEZ-A nrPDB 40 0.002 5OQL-X nrPDB 40 0.002 4J0W-A nrPDB 39 0.005 5CXB-B nrPDB 39 0.006 1PI6-A nrPDB 38 0.008 5WLC-LU nrPDB 38 0.010 4U1E-I nrPDB 38 0.011 2AQ5-A nrPDB 37 0.015 5CXC-A nrPDB 37 0.022 5WLC-LJ nrPDB 37 0.026 2PM9-A nrPDB 35 0.051 6BX3-B nrPDB 35 0.081 5N4A-A nrPDB 35 0.087 5WYJ-BE nrPDB 35 0.094 4L9O-A nrPDB 35 0.098 5A9Q-7 nrPDB 34 0.10 4YCZ-A nrPDB 34 0.16 3W15-A nrPDB 33 0.22 4FHN-A nrPDB 33 0.31 3BG0-A nrPDB 33 0.33 4BZK-B nrPDB 32 0.55 3JRP-A nrPDB 32 0.75 3JRO-A nrPDB 31 1.2 5A9Q-2 nrPDB 31 1.3 4E5Z-B nrPDB 31 1.4 4YHC-A nrPDB 30 2.1 3JB9-S nrPDB 30 2.3 5WLC-SG nrPDB 30 2.4 4J0X-A nrPDB 30 2.5 6BWX-A nrPDB 30 2.7 5WLC-LN nrPDB 30 3.1 3F3P-A nrPDB 29 3.4 6F1U-h nrPDB 29 3.6 5A9Q-0 nrPDB 29 3.7 5WLC-LH nrPDB 29 3.7 3EI3-B nrPDB 29 5.4 2VG9-A nrPDB 28 6.4 5YZG-2 nrPDB 28 8.6 3RG2-A nrPDB 28 9.1 3I2N-A nrPDB 28 9.3 >6J6H-n nrPDB Length = 455 Score = 946 bits (2446), Expect = 0.0, Method: Compositional matrix adjust. Identities = 455/455 (100%), Positives = 455/455 (100%) Query: 1 MGLVDGYDTSSDSDLNFDEGKSVHEKKNGNLHEDTSYEPSSNNIHKRKSHFTKSELKRRR 60 MGLVDGYDTSSDSDLNFDEGKSVHEKKNGNLHEDTSYEPSSNNIHKRKSHFTKSELKRRR Sbjct: 1 MGLVDGYDTSSDSDLNFDEGKSVHEKKNGNLHEDTSYEPSSNNIHKRKSHFTKSELKRRR 60 Query: 61 KTRKGDGPWGSWSSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSE 120 KTRKGDGPWGSWSSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSE Sbjct: 61 KTRKGDGPWGSWSSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSE 120 Query: 121 KDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILS 180 KDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILS Sbjct: 121 KDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILS 180 Query: 181 GGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKV 240 GGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKV Sbjct: 181 GGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKV 240 Query: 241 KTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALK 300 KTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALK Sbjct: 241 KTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALK 300 Query: 301 YFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRI 360 YFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRI Sbjct: 301 YFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRI 360 Query: 361 YSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNN 420 YSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNN Sbjct: 361 YSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNN 420 Query: 421 IKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 IKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD Sbjct: 421 IKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 >3JB9-g nrPDB Length = 558 Score = 303 bits (776), Expect = 1e-82, Method: Compositional matrix adjust. Identities = 167/437 (38%), Positives = 253/437 (57%), Gaps = 38/437 (8%) Query: 38 EPSSNNIHKRKSHFTKSELKRRRK------TRKGDGPW-GSWSSSDDETSQASETQ---- 86 E +++ KRKS ++K RR+ +GDG + G W+ E S + Sbjct: 120 EATTSTDLKRKSQ----KIKERREDPGDPSILEGDGAYKGPWAGYGSEQSSSPLEYSEYE 175 Query: 87 -------KEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEK--------DYQGRGYLYP 131 K ++D + L ++ L EQ+ EV K E DYQ R Y++ Sbjct: 176 EVESLDVKSEKDTESNNLGQNELLKEQLATPEVETHRSKEETILHKDRLFDYQNRSYMHV 235 Query: 132 PNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWD 191 PNDV ++L EE CY+PKK I + GH +G + L+F P +GHL+LSG D+ IKIW+ Sbjct: 236 PNDVGINLSEEPGEQTCYIPKKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWE 295 Query: 192 FYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPA 251 YHD LR FQGH +PI+ L F++D +SFLS+SFD+++K+WDTE GK + + Sbjct: 296 VYHDRSLLRTFQGHARPIRDLSFSQDGRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLTN 355 Query: 252 DVESR--PTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFI 309 V+ + P P+EF+ G ++ +IL +D R + +VQ YDHHL I ++ + +G +F+ Sbjct: 356 CVKFQVDPDKPNEFLAGTADKRILQFDIRSPD---IVQAYDHHLGGINSITFLENGKRFV 412 Query: 310 SSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKY 369 ++S+D ++R WE VPIK ++D A HSMP + + P+ QS+DN IY +S KY Sbjct: 413 TTSDDSSMRFWEYGTPVPIKFVADIAMHSMPRVALRPNGKSIACQSLDNCIYVYSAYEKY 472 Query: 370 KRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNK-P 428 +++ KK+FKG+S +GY + + FS DGR++ SGDS WDW T +L+ K+P + P Sbjct: 473 RQNKKKVFKGYSCSGYSLEVGFSPDGRFVFSGDSSGNACFWDWKTCKLM--AKLPAHSGP 530 Query: 429 ITQVDWHPQETSKVICS 445 + + +HPQETSKV S Sbjct: 531 VQSMAFHPQETSKVATS 547 >6QDV-o nrPDB Length = 513 Score = 282 bits (721), Expect = 3e-76, Method: Compositional matrix adjust. Identities = 149/391 (38%), Positives = 221/391 (56%), Gaps = 7/391 (1%) Query: 67 GPWGSWSSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGR 126 GPW + D + E QKE +I + + E+ EE + + K DYQGR Sbjct: 128 GPWAKYVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEK-PGEEKTILHVKEMYDYQGR 186 Query: 127 GYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHT 186 YL+ P DV V+LR +CYLPKK I + GH +G +A++ P +GHL+LS D Sbjct: 187 SYLHIPQDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCK 246 Query: 187 IKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHL 246 IK+W+ Y + CLR F GH+K ++ + F FLS+++DR +K+WDTETG+ +R Sbjct: 247 IKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTN 306 Query: 247 NSTPADVESRPTNPHE--FIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPD 304 P V+ P + F+ G+S+ KI+ +D R E +VQ YD HL ++ + + + Sbjct: 307 RKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGE---IVQEYDRHLGAVNTIVFVDE 363 Query: 305 GSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFS 364 +F+S+S+DK++R+WE I V K I++ + HSMP + + P+ + QSMDN+I F Sbjct: 364 NRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFG 423 Query: 365 LKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIP 424 + +++ + KKIFKGH AGY + FS D Y+ SGD +L WDW T++L + K Sbjct: 424 AQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAH 483 Query: 425 GNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 I V WHP ETSKVI G G I + D Sbjct: 484 DKVCIGAV-WHPHETSKVITCGWDGLIKLWD 513 >5YZG-W nrPDB Length = 579 Score = 282 bits (721), Expect = 3e-76, Method: Compositional matrix adjust. Identities = 149/391 (38%), Positives = 221/391 (56%), Gaps = 7/391 (1%) Query: 67 GPWGSWSSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGR 126 GPW + D + E QKE +I + + E+ EE + + K DYQGR Sbjct: 194 GPWAKYVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEK-PGEEKTILHVKEMYDYQGR 252 Query: 127 GYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHT 186 YL+ P DV V+LR +CYLPKK I + GH +G +A++ P +GHL+LS D Sbjct: 253 SYLHIPQDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCK 312 Query: 187 IKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHL 246 IK+W+ Y + CLR F GH+K ++ + F FLS+++DR +K+WDTETG+ +R Sbjct: 313 IKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTN 372 Query: 247 NSTPADVESRPTNPHE--FIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPD 304 P V+ P + F+ G+S+ KI+ +D R E +VQ YD HL ++ + + + Sbjct: 373 RKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGE---IVQEYDRHLGAVNTIVFVDE 429 Query: 305 GSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFS 364 +F+S+S+DK++R+WE I V K I++ + HSMP + + P+ + QSMDN+I F Sbjct: 430 NRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFG 489 Query: 365 LKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIP 424 + +++ + KKIFKGH AGY + FS D Y+ SGD +L WDW T++L + K Sbjct: 490 AQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAH 549 Query: 425 GNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 I V WHP ETSKVI G G I + D Sbjct: 550 DKVCIGAV-WHPHETSKVITCGWDGLIKLWD 579 >6QX9-5O nrPDB Length = 357 Score = 96.3 bits (238), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 77/301 (25%), Positives = 140/301 (46%), Gaps = 21/301 (6%) Query: 147 RCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHN 206 RC + I GH KF P G + S G D I +W+ Y D + +GH+ Sbjct: 51 RCSSLQAPIMLLSGHEGEVYCCKFHPN-GSTLASAGFDRLILLWNVYGDCDNYATLKGHS 109 Query: 207 KPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRL--HLNSTPADVESRPTNPHEFI 264 + L + D S+S D++V +WD+ETG+ RL H + + +R P Sbjct: 110 GAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPAR-RGPQLVC 168 Query: 265 VGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW---E 321 G + + +D R + +QT+ + +LA+ + + IS D +++W + Sbjct: 169 TGSDDGTVKLWDIR---KKAAIQTF-QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQ 224 Query: 322 NQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKP-KYKRHPKKIFKG- 379 N++ ++ +D S+ L++ +Y + +MDN + + ++P K KIF+G Sbjct: 225 NKLTYTMRGHAD----SVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGN 280 Query: 380 -HSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNK-PITQVDWHPQ 437 H+ + ++S DG I +G + ++ WD + R+L K+PG+ I +V +HP Sbjct: 281 VHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRIL--YKLPGHAGSINEVAFHPD 338 Query: 438 E 438 E Sbjct: 339 E 339 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 40/161 (24%), Positives = 65/161 (40%), Gaps = 26/161 (16%) Query: 178 ILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTET 237 I+SGG D+ IK+WD + + +GH + L + + LS++ D +V++WD Sbjct: 208 IISGGIDNDIKVWDLRQN-KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRP 266 Query: 238 GKVKTRLHLNSTPADVESRPTNPHEF---------------IVGLSNSKILHYDDRVSEN 282 K R V+ N H F I S + ++ D S Sbjct: 267 FAPKERC--------VKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRR 318 Query: 283 QGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQ 323 ++ H SI + + PD IS+S DK + + E Q Sbjct: 319 --ILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357 >5M25-A nrPDB Length = 434 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 75/292 (25%), Positives = 132/292 (45%), Gaps = 18/292 (6%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQ 219 GH + +++KF P G + S D IKIW Y D + + GH I + ++ D Sbjct: 143 GHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAY-DGKFEKTISGHKLGISDVAWSSDSN 200 Query: 220 SFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRV 279 +S+S D+++KIWD +GK L +S + + + G + + +D + Sbjct: 201 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 260 Query: 280 SENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSM 339 + ++T H + A+ + DGS +SSS D RIW+ +K + D + Sbjct: 261 GK---CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 317 Query: 340 PFLNVHPSQNYFCAQSMDN--RIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFS-GDGR 396 F+ P+ Y A ++DN +++ +S K K + GH + Y I FS G+ Sbjct: 318 SFVKFSPNGKYILAATLDNTLKLWDYS-----KGKCLKTYTGHKNEKYCIFANFSVTGGK 372 Query: 397 YICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPIT-QVDWHPQETSKVICSGA 447 +I SG + ++ W+ T ++ K+ G+ + HP E +I S A Sbjct: 373 WIVSGSEDNLVYIWNLQTKEIVQ--KLQGHTDVVISTACHPTEN--IIASAA 420 Score = 37.4 bits (85), Expect = 0.015, Method: Compositional matrix adjust. Identities = 39/150 (26%), Positives = 57/150 (38%), Gaps = 20/150 (13%) Query: 279 VSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW-------ENQINVPIKQI 331 V N L T H ++ ++K+ P+G SSS DK ++IW E I+ I Sbjct: 131 VKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGI 190 Query: 332 SDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAF 391 SD A S N + S D + + + K KGHS+ Y F Sbjct: 191 SDVAWSS--------DSNLLVSASDDKTLKIWDVS---SGKCLKTLKGHSN--YVFCCNF 237 Query: 392 SGDGRYICSGDSKSRLFTWDWNTSRLLNNI 421 + I SG + WD T + L + Sbjct: 238 NPQSNLIVSGSFDESVRIWDVKTGKCLKTL 267 >2H9P-A nrPDB Length = 329 Score = 89.4 bits (220), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 75/292 (25%), Positives = 132/292 (45%), Gaps = 18/292 (6%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQ 219 GH + +++KF P G + S D IKIW Y D + + GH I + ++ D Sbjct: 38 GHTKAVSSVKFSPN-GEWLASSSADKLIKIWGAY-DGKFEKTISGHKLGISDVAWSSDSN 95 Query: 220 SFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRV 279 +S+S D+++KIWD +GK L +S + + + G + + +D + Sbjct: 96 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 155 Query: 280 SENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSM 339 + ++T H + A+ + DGS +SSS D RIW+ +K + D + Sbjct: 156 GK---CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 212 Query: 340 PFLNVHPSQNYFCAQSMDN--RIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFS-GDGR 396 F+ P+ Y A ++DN +++ +S K K + GH + Y I FS G+ Sbjct: 213 SFVKFSPNGKYILAATLDNTLKLWDYS-----KGKCLKTYTGHKNEKYCIFANFSVTGGK 267 Query: 397 YICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPIT-QVDWHPQETSKVICSGA 447 +I SG + ++ W+ T ++ K+ G+ + HP E +I S A Sbjct: 268 WIVSGSEDNLVYIWNLQTKEIVQ--KLQGHTDVVISTACHPTE--NIIASAA 315 Score = 36.2 bits (82), Expect = 0.028, Method: Compositional matrix adjust. Identities = 39/150 (26%), Positives = 57/150 (38%), Gaps = 20/150 (13%) Query: 279 VSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW-------ENQINVPIKQI 331 V N L T H ++ ++K+ P+G SSS DK ++IW E I+ I Sbjct: 26 VKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGI 85 Query: 332 SDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAF 391 SD A S N + S D + + + K KGHS+ Y F Sbjct: 86 SDVAWSS--------DSNLLVSASDDKTLKIWDVS---SGKCLKTLKGHSN--YVFCCNF 132 Query: 392 SGDGRYICSGDSKSRLFTWDWNTSRLLNNI 421 + I SG + WD T + L + Sbjct: 133 NPQSNLIVSGSFDESVRIWDVKTGKCLKTL 162 >1VYH-C nrPDB Length = 410 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 56/230 (24%), Positives = 102/230 (44%), Gaps = 30/230 (13%) Query: 153 KVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKAL 212 + IR GH +++ +P H I+S D TIK+W+ Y C++ F GH + ++ + Sbjct: 183 ECIRTMHGHDHNVSSVSIMPNGDH-IVSASRDKTIKMWEVQTGY-CVKTFTGHREWVRMV 240 Query: 213 RFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLH-------------------LNSTPADV 253 R +D S S D++V++W T + K L ++ Sbjct: 241 RPNQDGTLIASCSNDQTVRVWVVATKECKAELREHRHVVECISWAPESSYSSISEATGSE 300 Query: 254 ESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQT--YDHHLSSILALKYFPDGSKFI-S 310 + P F++ S K + D VS L+ +D+ + +L F G KFI S Sbjct: 301 TKKSGKPGPFLLSGSRDKTIKMWD-VSTGMCLMTLVGHDNWVRGVL----FHSGGKFILS 355 Query: 311 SSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRI 360 ++DKT+R+W+ + +K + + +H + L+ H + Y S+D + Sbjct: 356 CADDKTLRVWDYKNKRCMKTL-NAHEHFVTSLDFHKTAPYVVTGSVDQTV 404 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 61/281 (21%), Positives = 109/281 (38%), Gaps = 41/281 (14%) Query: 156 RNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFT 215 R GH + + F +G L+ S D TIK+WDF +EC+R GH+ + ++ Sbjct: 144 RTLKGHTDSVQDISF-DHSGKLLASCSADMTIKLWDF-QGFECIRTMHGHDHNVSSVSIM 201 Query: 216 EDCQSFLSSSFDRSVKIWDTETGK-VKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILH 274 + +S+S D+++K+W+ +TG VKT V RP I SN + + Sbjct: 202 PNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMV--RPNQDGTLIASCSNDQTVR 259 Query: 275 YDDRVSENQGLVQTYDHHLSSILALKYFPD--------------------GSKFISSSED 314 V + H + + + P+ G +S S D Sbjct: 260 V--WVVATKECKAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRD 317 Query: 315 KTVRIWENQINVPIKQIS--DTAQHSMPFLNVHPSQNYF--CAQSMDNRIYSFSLKPKYK 370 KT+++W+ + + + D + F H + CA R++ + K K Sbjct: 318 KTIKMWDVSTGMCLMTLVGHDNWVRGVLF---HSGGKFILSCADDKTLRVWDY----KNK 370 Query: 371 RHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWD 411 R K + ++ + SL F Y+ +G + W+ Sbjct: 371 RCMKTL---NAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 46/165 (27%), Positives = 77/165 (46%), Gaps = 13/165 (7%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF-YHDYECLRDFQGHNKPIKALRFTEDC 218 GH T + F P +++S D TIK+WD+ D+E R +GH ++ + F Sbjct: 106 GHRSPVTRVIFHP-VFSVMVSASEDATIKVWDYETGDFE--RTLKGHTDSVQDISFDHSG 162 Query: 219 QSFLSSSFDRSVKIWDTETGKVKTRLH-LNSTPADVESRPTNPHEFIVGLSNSKILHYDD 277 + S S D ++K+WD + + +H + + V P H IV S K + Sbjct: 163 KLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDH--IVSASRDKTI---- 216 Query: 278 RVSENQG--LVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 ++ E Q V+T+ H + ++ DG+ S S D+TVR+W Sbjct: 217 KMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 261 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 43/191 (22%), Positives = 80/191 (41%), Gaps = 33/191 (17%) Query: 155 IRNYPGHPEGTTALKFLP-KTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALR 213 ++ + GH E ++ P + G LI S ND T+++W EC + + H ++ + Sbjct: 227 VKTFTGHREWVRMVR--PNQDGTLIASCSNDQTVRVW-VVATKECKAELREHRHVVECIS 283 Query: 214 FTEDCQS--------------------FLSSSFDRSVKIWDTETGKVKTRLHLNSTPADV 253 + + LS S D+++K+WD TG L D Sbjct: 284 WAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTL----VGHDN 339 Query: 254 ESRPTNPH---EFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFIS 310 R H +FI+ ++ K L D +N+ ++T + H + +L + ++ Sbjct: 340 WVRGVLFHSGGKFILSCADDKTLRVWDY--KNKRCMKTLNAHEHFVTSLDFHKTAPYVVT 397 Query: 311 SSEDKTVRIWE 321 S D+TV++WE Sbjct: 398 GSVDQTVKVWE 408 >6HHQ-h nrPDB Length = 319 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 66/266 (24%), Positives = 118/266 (44%), Gaps = 20/266 (7%) Query: 155 IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRF 214 +R++ GH L G LS D T+++WD E + F GH + ++ Sbjct: 58 VRSFKGHSHIVQDCT-LTADGAYALSASWDKTLRLWDVATG-ETYQRFVGHKSDVMSVDI 115 Query: 215 TEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHE----FIVGLSNS 270 + +S S D+++K+W + + T L N + V P + I+ N Sbjct: 116 DKKASMIISGSRDKTIKVWTIKGQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGND 175 Query: 271 KILHYDDRVSENQGLVQT-YDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIK 329 K++ + NQ ++ + H S+I L PDG+ S+ +D + +W + Sbjct: 176 KMVK---AWNLNQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMY 232 Query: 330 QISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKY---KRHPKKIFKGHSSAG-- 384 +S AQ + L P++ Y+ A + I FSL P+Y P+ F G+S A Sbjct: 233 TLS--AQDEVFSLAFSPNR-YWLAAATATGIKVFSLDPQYLVDDLRPE--FAGYSKAAEP 287 Query: 385 YGISLAFSGDGRYICSGDSKSRLFTW 410 + +SLA+S DG+ + +G + + + W Sbjct: 288 HAVSLAWSADGQTLFAGYTDNVIRVW 313 >2YNP-A nrPDB Length = 604 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 67/276 (24%), Positives = 118/276 (42%), Gaps = 23/276 (8%) Query: 106 QIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGT 165 Q+EV + +E + ++ N + V + RI Y + + ++ HP+ Sbjct: 45 QVEVRSIQ----VTETPVRAGKFIARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYI 100 Query: 166 TALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFT-EDCQSFLSS 224 ++ P T +LSG +D T+K+W++ +++ + F+GH + + F +D +F S Sbjct: 101 RSIAVHP-TKPYVLSGSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASG 159 Query: 225 SFDRSVKIW----DTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVS 280 DR+VK+W T + T D P P+ I + I +D Sbjct: 160 CLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPY-MITASDDLTIKIWD---Y 215 Query: 281 ENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW-------ENQINVPIKQISD 333 + + V T + H+S++ + P IS SED T++IW E +NV +++ Sbjct: 216 QTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWC 275 Query: 334 TAQHSMPFLNVHPS--QNYFCAQSMDNRIYSFSLKP 367 A H N S N F S+ N + SL P Sbjct: 276 IATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSLDP 311 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 33/167 (19%), Positives = 71/167 (42%), Gaps = 4/167 (2%) Query: 200 RDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTN 259 + F + +K + F L++ + V++W+ ET + + TP Sbjct: 7 KTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIAR 66 Query: 260 PHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRI 319 + IVG + +I ++ E V ++ H I ++ P +S S+D TV++ Sbjct: 67 KNWIIVGSDDFRIRVFNYNTGEK---VVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKL 123 Query: 320 WENQINVPIKQISDTAQHSMPFLNVHPSQ-NYFCAQSMDNRIYSFSL 365 W + N ++Q + +H + + +P + F + +D + +SL Sbjct: 124 WNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSL 170 >3MKQ-A nrPDB Length = 814 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 67/276 (24%), Positives = 118/276 (42%), Gaps = 23/276 (8%) Query: 106 QIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGT 165 Q+EV + +E + ++ N + V + RI Y + + ++ HP+ Sbjct: 45 QVEVRSIQ----VTETPVRAGKFIARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYI 100 Query: 166 TALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFT-EDCQSFLSS 224 ++ P T +LSG +D T+K+W++ +++ + F+GH + + F +D +F S Sbjct: 101 RSIAVHP-TKPYVLSGSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASG 159 Query: 225 SFDRSVKIW----DTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVS 280 DR+VK+W T + T D P P+ I + I +D Sbjct: 160 CLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPY-MITASDDLTIKIWD---Y 215 Query: 281 ENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW-------ENQINVPIKQISD 333 + + V T + H+S++ + P IS SED T++IW E +NV +++ Sbjct: 216 QTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWC 275 Query: 334 TAQHSMPFLNVHPS--QNYFCAQSMDNRIYSFSLKP 367 A H N S N F S+ N + SL P Sbjct: 276 IATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSLDP 311 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 34/167 (20%), Positives = 71/167 (42%), Gaps = 4/167 (2%) Query: 200 RDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTN 259 + F + +K + F L++ + V+IW+ ET + + TP Sbjct: 7 KTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKFIAR 66 Query: 260 PHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRI 319 + IVG + +I ++ E V ++ H I ++ P +S S+D TV++ Sbjct: 67 KNWIIVGSDDFRIRVFNYNTGEK---VVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKL 123 Query: 320 WENQINVPIKQISDTAQHSMPFLNVHPSQ-NYFCAQSMDNRIYSFSL 365 W + N ++Q + +H + + +P + F + +D + +SL Sbjct: 124 WNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSL 170 >6F3T-A nrPDB Length = 608 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 63/246 (25%), Positives = 100/246 (40%), Gaps = 17/246 (6%) Query: 78 ETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDV 137 + S S KE D+ + E +I YG S R YL ++ D Sbjct: 317 QASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFS--PDRNYLLSSSE-DG 373 Query: 138 DLREERI-SFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDY 196 +R + +F C + Y GH +F P G+ +SGG+D ++W H Y Sbjct: 374 TVRLWSLQTFTCLV------GYKGHNYPVWDTQFSPY-GYYFVSGGHDRVARLWATDH-Y 425 Query: 197 ECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESR 256 + LR F GH + RF + + S DR+V++WD G + P + Sbjct: 426 QPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTF 485 Query: 257 PTNPHEFIVGLSNSKILHYDDRVSENQGL-VQTYDHHLSSILALKYFPDGSKFISSSEDK 315 N G ++ ++L +D GL V H ++ +L++ DG S S D Sbjct: 486 SPNGRFLATGATDGRVLLWD----IGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDN 541 Query: 316 TVRIWE 321 TVR+W+ Sbjct: 542 TVRLWD 547 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 54/254 (21%), Positives = 96/254 (37%), Gaps = 57/254 (22%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQ 219 GH F P +L LS D T+++W + CL ++GHN P+ +F+ Sbjct: 349 GHSGPVYGASFSPDRNYL-LSSSEDGTVRLWSL-QTFTCLVGYKGHNYPVWDTQFSPYGY 406 Query: 220 SFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRV 279 F+S DR ++W T+ HY Sbjct: 407 YFVSGGHDRVARLWATD-------------------------------------HYQP-- 427 Query: 280 SENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSM 339 ++ + HL+ + ++ P+ + + S D+TVR+W+ +N +I + + Sbjct: 428 ------LRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD-VLNGNCVRIFTGHKGPI 480 Query: 340 PFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKI--FKGHSSAGYGISLAFSGDGRY 397 L P+ + + D R+ + + H + KGH+ SL FS DG Sbjct: 481 HSLTFSPNGRFLATGATDGRVLLWDIG-----HGLMVGELKGHTDTV--CSLRFSRDGEI 533 Query: 398 ICSGDSKSRLFTWD 411 + SG + + WD Sbjct: 534 LASGSMDNTVRLWD 547 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 47/224 (20%), Positives = 82/224 (36%), Gaps = 51/224 (22%) Query: 199 LRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPT 258 L+ GH+ P+ F+ D LSSS D +V++W +T Sbjct: 344 LKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTC------------------ 385 Query: 259 NPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVR 318 +VG Y H + ++ P G F+S D+ R Sbjct: 386 -----LVG----------------------YKGHNYPVWDTQFSPYGYYFVSGGHDRVAR 418 Query: 319 IWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFK 378 +W P++ + + HP+ NY S D + + + + +IF Sbjct: 419 LWATDHYQPLRIFAGHLA-DVNCTRFHPNSNYVATGSADRTVRLWDV---LNGNCVRIFT 474 Query: 379 GHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIK 422 GH + SL FS +GR++ +G + R+ WD ++ +K Sbjct: 475 GHKGPIH--SLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELK 516 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 13/46 (28%), Positives = 26/46 (56%), Gaps = 1/46 (2%) Query: 154 VIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECL 199 ++ GH + +L+F + G ++ SG D+T+++WD +E L Sbjct: 511 MVGELKGHTDTVCSLRF-SRDGEILASGSMDNTVRLWDAIKAFEDL 555 >5XYI-g nrPDB Length = 335 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 15/243 (6%) Query: 178 ILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTET 237 +L+ D T+++WD + F GH K + + F+ + +S D VKIW+ Sbjct: 95 LLTSSWDSTLRLWDL-STRTTKKLFLGHKKDVLGVTFSPCNRRIISVGRDNQVKIWNI-L 152 Query: 238 GKVKTRLHLNSTPADVESRP----TNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHL 293 G+ K L +S V P T+P VG + K+ Y + + L++ + H Sbjct: 153 GENKAELQCSSWVTSVACAPMADETSPLVIAVGCWDGKV--YIWSIEKEAKLIKEFKAHD 210 Query: 294 SSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCA 353 ++ + PDG I+ D+ V +W + K IS TA + + P+Q + CA Sbjct: 211 GRCTSVDFTPDGKWVITGGSDRKVVMWLTENGA--KTISFTAPSPVHAVAACPTQAWICA 268 Query: 354 QSMDN-RIYSFSLKPKYKR-HPKKIFKGHSSAGY---GISLAFSGDGRYICSGDSKSRLF 408 + + ++ K + P +G +AG LA++ DG + SG + + Sbjct: 269 ATYEGIAVWDIGAKQQIDLVQPNFKHEGKRNAGRTPDCTCLAWAADGSVLYSGYNDGSIR 328 Query: 409 TWD 411 W+ Sbjct: 329 AWE 331 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 37/153 (24%), Positives = 60/153 (39%), Gaps = 10/153 (6%) Query: 177 LILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTE 236 +I G D + IW + + +++F+ H+ ++ FT D + ++ DR V +W TE Sbjct: 181 VIAVGCWDGKVYIWSIEKEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTE 240 Query: 237 TGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHH---- 292 G S V + PT +I + I +D + LVQ H Sbjct: 241 NGAKTISFTAPSPVHAVAACPT--QAWICAATYEGIAVWDIGAKQQIDLVQPNFKHEGKR 298 Query: 293 ----LSSILALKYFPDGSKFISSSEDKTVRIWE 321 L + DGS S D ++R WE Sbjct: 299 NAGRTPDCTCLAWAADGSVLYSGYNDGSIRAWE 331 Score = 28.1 bits (61), Expect = 9.1, Method: Compositional matrix adjust. Identities = 38/177 (21%), Positives = 79/177 (44%), Gaps = 22/177 (12%) Query: 288 TYDHHLSSILALKYFPDGSKFISSSEDKTVRIW-----ENQINVPIKQISDTAQHSMPFL 342 T+ H ++I +++ + + +S+S DK+ +W + Q P ++ H + + Sbjct: 28 TFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGH-NHFVSDV 86 Query: 343 NVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGD 402 ++ ++ S D+ + + L R KK+F GH G++ FS R I S Sbjct: 87 SLSRDASHLLTSSWDSTLRLWDLS---TRTTKKLFLGHKKDVLGVT--FSPCNRRIISVG 141 Query: 403 SKSRLFTWDWNTSRLL--NNIKIPGNKPITQVDWHPQ--ETSKVICSGAA--GKIYV 453 +++ W+ +L N ++ + +T V P ETS ++ + GK+Y+ Sbjct: 142 RDNQVKIWN-----ILGENKAELQCSSWVTSVACAPMADETSPLVIAVGCWDGKVYI 193 >6MZM-G nrPDB Length = 800 Score = 65.9 bits (159), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 48/178 (26%), Positives = 77/178 (43%), Gaps = 13/178 (7%) Query: 145 SFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQG 204 +F C + Y GH +F P G+ +SGG+D ++W H Y+ LR F G Sbjct: 574 TFTCLV------GYKGHNYPVWDTQFSPY-GYYFVSGGHDRVARLWATDH-YQPLRIFAG 625 Query: 205 HNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFI 264 H + RF + + S DR+V++WD G + P + N Sbjct: 626 HLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLA 685 Query: 265 VGLSNSKILHYDDRVSENQGL-VQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321 G ++ ++L +D GL V H ++ +L++ DG S S D TVR+W+ Sbjct: 686 TGATDGRVLLWDI----GHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 57/256 (22%), Positives = 96/256 (37%), Gaps = 61/256 (23%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQ 219 GH F P +L LS D T+++W + CL ++GHN P+ +F+ Sbjct: 541 GHSGPVYGASFSPDRNYL-LSSSEDGTVRLWSL-QTFTCLVGYKGHNYPVWDTQFSPYGY 598 Query: 220 SFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRV 279 F+S DR ++W T+ HY Sbjct: 599 YFVSGGHDRVARLWATD-------------------------------------HYQP-- 619 Query: 280 SENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE--NQINVPIKQISDTAQH 337 ++ + HL+ + ++ P+ + + S D+TVR+W+ N V I H Sbjct: 620 ------LRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIH 673 Query: 338 SMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKI--FKGHSSAGYGISLAFSGDG 395 S+ F P+ + + D R+ + + H + KGH+ SL FS DG Sbjct: 674 SLTF---SPNGRFLATGATDGRVLLWDIG-----HGLMVGELKGHTDTV--CSLRFSRDG 723 Query: 396 RYICSGDSKSRLFTWD 411 + SG + + WD Sbjct: 724 EILASGSMDNTVRLWD 739 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 47/219 (21%), Positives = 80/219 (36%), Gaps = 51/219 (23%) Query: 204 GHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEF 263 GH+ P+ F+ D LSSS D +V++W +T Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQT-----------------------FTC 577 Query: 264 IVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQ 323 +VG Y H + ++ P G F+S D+ R+W Sbjct: 578 LVG----------------------YKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATD 615 Query: 324 INVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSA 383 P++ I + HP+ NY S D + + + + +IF GH Sbjct: 616 HYQPLR-IFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDV---LNGNCVRIFTGHKGP 671 Query: 384 GYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIK 422 + SL FS +GR++ +G + R+ WD ++ +K Sbjct: 672 IH--SLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELK 708 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 13/46 (28%), Positives = 26/46 (56%), Gaps = 1/46 (2%) Query: 154 VIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECL 199 ++ GH + +L+F + G ++ SG D+T+++WD +E L Sbjct: 703 MVGELKGHTDTVCSLRF-SRDGEILASGSMDNTVRLWDAIKAFEDL 747 >5I2T-A nrPDB Length = 742 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 76/336 (22%), Positives = 130/336 (38%), Gaps = 53/336 (15%) Query: 131 PPNDVDVDLREERISFRC----------YLPKKVIRNYPGHPEGTTALKFLPKTGHLILS 180 P N V V+ E ++F + + I GH + T +L + P G +++ Sbjct: 329 PVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPD-GSRVVT 387 Query: 181 GGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWD------ 234 D IK+WD + CL F+ H + A++F + Q SSS D +V+ WD Sbjct: 388 ASEDGKIKVWDITSGF-CLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRN 446 Query: 235 --TETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHH 292 T TG R+ N D P+ L N I + + + L+ H Sbjct: 447 FRTFTG--TERIQFNCLAVD----PSGEVVCAGSLDNFDIHVWSVQTGQ---LLDALSGH 497 Query: 293 LSSILALKYFPDGSKFISSSEDKTVRIW----ENQINVPIKQISDTAQHSMPFLNVHPSQ 348 + L + + S S+S DKT+RIW +Q PI+ SD SM P Sbjct: 498 EGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSM-----RPDG 552 Query: 349 NYFCAQSMDNRIYSFSLKPKYK-------------RHPKKIFKGHSS--AGYGISLAFSG 393 ++ +I F+++ + R + F +S + + ++ +S Sbjct: 553 KEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSF 612 Query: 394 DGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPI 429 DG I +G + + + +D LL + N + Sbjct: 613 DGMAIVAGGNNNSICLYDVPNEVLLKRFIVSRNMAL 648 Score = 32.0 bits (71), Expect = 0.56, Method: Compositional matrix adjust. Identities = 29/111 (26%), Positives = 53/111 (47%), Gaps = 14/111 (12%) Query: 135 VDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIW---D 191 +D D R ++F+ + V+ ++ E +A+KF P L+ G ++IW D Sbjct: 98 IDEDGRAILVNFKA---RNVLHHF-NFKEKCSAVKFSPDGRLFALASG--RFLQIWKTPD 151 Query: 192 FYHDYECL-----RDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTET 237 D + R GH + I +L +++D + L++S D S KIW ++ Sbjct: 152 VNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDS 202 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 23/90 (25%), Positives = 40/90 (44%), Gaps = 3/90 (3%) Query: 147 RCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLR--DFQG 204 R + P R + GH + T+L + + IL+ D + KIW + + L F G Sbjct: 156 RQFAPFVRHRVHAGHFQDITSLTW-SQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNG 214 Query: 205 HNKPIKALRFTEDCQSFLSSSFDRSVKIWD 234 H + F+ D + + S D +V +W+ Sbjct: 215 HRDYVMGAFFSHDQEKIYTVSKDGAVFVWE 244 >5WLC-LO nrPDB Length = 923 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 69/297 (23%), Positives = 118/297 (39%), Gaps = 43/297 (14%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQ 219 GH + T +L + P G +++ D IK+WD + CL F+ H + A++F + Q Sbjct: 343 GHFDSTNSLAYSPD-GSRVVTASEDGKIKVWDITSGF-CLATFEEHTSSVTAVQFAKRGQ 400 Query: 220 SFLSSSFDRSVKIWD--------TETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSK 271 SSS D +V+ WD T TG R+ N D P+ L N Sbjct: 401 VMFSSSLDGTVRAWDLIRYRNFRTFTG--TERIQFNCLAVD----PSGEVVCAGSLDNFD 454 Query: 272 ILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW----ENQINVP 327 I + + + L+ H + L + + S S+S DKT+RIW +Q P Sbjct: 455 IHVWSVQTGQ---LLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEP 511 Query: 328 IKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYK-------------RHPK 374 I+ SD SM P ++ +I F+++ + R + Sbjct: 512 IEVYSDVLALSM-----RPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQ 566 Query: 375 KIFKGHSS--AGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPI 429 F +S + + ++ +S DG I +G + + + +D LL + N + Sbjct: 567 DRFTAKNSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRFIVSRNMAL 623 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 35/156 (22%), Positives = 56/156 (35%), Gaps = 45/156 (28%) Query: 203 QGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHE 262 QGH +L ++ D +++S D +K+WD +G Sbjct: 342 QGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFC---------------------- 379 Query: 263 FIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWEN 322 + T++ H SS+ A+++ G SSS D TVR W+ Sbjct: 380 -----------------------LATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDL 416 Query: 323 QINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDN 358 + + T + L V PS CA S+DN Sbjct: 417 IRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDN 452 Score = 32.0 bits (71), Expect = 0.54, Method: Compositional matrix adjust. Identities = 29/111 (26%), Positives = 53/111 (47%), Gaps = 14/111 (12%) Query: 135 VDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIW---D 191 +D D R ++F+ + V+ ++ E +A+KF P L+ G ++IW D Sbjct: 73 IDEDGRAILVNFKA---RNVLHHF-NFKEKCSAVKFSPDGRLFALASG--RFLQIWKTPD 126 Query: 192 FYHDYECL-----RDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTET 237 D + R GH + I +L +++D + L++S D S KIW ++ Sbjct: 127 VNKDRQFAPFVRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDS 177 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 23/90 (25%), Positives = 40/90 (44%), Gaps = 3/90 (3%) Query: 147 RCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLR--DFQG 204 R + P R + GH + T+L + + IL+ D + KIW + + L F G Sbjct: 131 RQFAPFVRHRVHAGHFQDITSLTW-SQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNG 189 Query: 205 HNKPIKALRFTEDCQSFLSSSFDRSVKIWD 234 H + F+ D + + S D +V +W+ Sbjct: 190 HRDYVMGAFFSHDQEKIYTVSKDGAVFVWE 219 >3FM0-A nrPDB Length = 345 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 47/184 (25%), Positives = 85/184 (46%), Gaps = 16/184 (8%) Query: 149 YLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD-YECLRDFQGHNK 207 ++ K V+ GH + + P G+ + S D T IW D +EC+ +GH Sbjct: 50 WICKSVLSE--GHQRTVRKVAWSP-CGNYLASASFDATTCIWKKNQDDFECVTTLEGHEN 106 Query: 208 PIKALRFTEDCQSFLSSSFDRSVKIWDT-ETGKVKTRLHLNSTPADVESRPTNPHEFIVG 266 +K++ + + S D+SV +W+ E + + LNS DV+ +P + ++ Sbjct: 107 EVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLA 166 Query: 267 LSNSKILHYDDRV------SENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 ++ YDD V ++ T + H S++ +L + P G + S S+D+TVRIW Sbjct: 167 SAS-----YDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221 Query: 321 ENQI 324 + Sbjct: 222 RQYL 225 >6HQA-B nrPDB Length = 722 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 66/276 (23%), Positives = 115/276 (41%), Gaps = 25/276 (9%) Query: 198 CLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRL-------HLNSTP 250 C+ F N + L+F +D S D +K+W + +++ L N Sbjct: 382 CMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGV 441 Query: 251 ADVESRPTNPHEFIV-GLSNSKILHYDDRVSENQGL----------VQTYDHHLSSILAL 299 A SR H V G+ S Y SE++ + + +Y H SS+ + Sbjct: 442 AVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHSSSVWDV 501 Query: 300 KYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNR 359 K+ P G F ++S D+T R+W P++ I + + + HP+ Y S D Sbjct: 502 KFSPMGHYFATASHDQTARLWSCDHIYPLR-IFAGHLNDVDCVEFHPNSTYLFTGSSDKT 560 Query: 360 IYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLN 419 + + + ++F GHS A LA S DGR++ S S + WD +T R + Sbjct: 561 ARMWDIA---RGECVRVFMGHSGAIN--CLAVSPDGRWLASAGEDSVVCLWDISTGRRIK 615 Query: 420 NIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 ++ G I + + +E + ++ +GA + V D Sbjct: 616 AMRGHGRSSIYSLAFS-REGTVLVSTGADNSVRVWD 650 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 40/171 (23%), Positives = 76/171 (44%), Gaps = 4/171 (2%) Query: 155 IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRF 214 + +Y GH +KF P GH + +D T ++W H Y LR F GH + + F Sbjct: 488 LVSYKGHSSSVWDVKFSP-MGHYFATASHDQTARLWSCDHIYP-LRIFAGHLNDVDCVEF 545 Query: 215 TEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILH 274 + + S D++ ++WD G+ +S + + + +S + Sbjct: 546 HPNSTYLFTGSSDKTARMWDIARGECVRVFMGHSGAINCLAVSPDGRWLASAGEDSVVCL 605 Query: 275 YDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQIN 325 +D +S + + H SSI +L + +G+ +S+ D +VR+W+ + N Sbjct: 606 WD--ISTGRRIKAMRGHGRSSIYSLAFSREGTVLVSTGADNSVRVWDVKKN 654 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 52/214 (24%), Positives = 89/214 (41%), Gaps = 11/214 (5%) Query: 156 RNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFT 215 R GH + F P +LI S D T+++W Y CL ++GH+ + ++F+ Sbjct: 447 RRLVGHSGAVYGVDFSPDNRYLI-SCSEDKTVRLWSL-DTYTCLVSYKGHSSSVWDVKFS 504 Query: 216 EDCQSFLSSSFDRSVKIWDTETGKVKTRL---HLNSTPADVESRPTNPHEFIVGLSNSKI 272 F ++S D++ ++W + R+ HLN VE P + + F G S+ Sbjct: 505 PMGHYFATASHDQTARLWSCD-HIYPLRIFAGHLNDVDC-VEFHPNSTYLF-TGSSDKTA 561 Query: 273 LHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQIS 332 +D E V+ + H +I L PDG S+ ED V +W+ IK + Sbjct: 562 RMWDIARGE---CVRVFMGHSGAINCLAVSPDGRWLASAGEDSVVCLWDISTGRRIKAMR 618 Query: 333 DTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLK 366 + S+ L + DN + + +K Sbjct: 619 GHGRSSIYSLAFSREGTVLVSTGADNSVRVWDVK 652 >4LG8-A nrPDB Length = 354 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 66/292 (22%), Positives = 114/292 (39%), Gaps = 53/292 (18%) Query: 164 GTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLS 223 G AL P + IL+GG D + ++D + + L +GH K + ++ F S Sbjct: 73 GILALDLCPSDTNKILTGGADKNVVVFDKSSE-QILATLKGHTKKVTSVVFHPSQDLVFS 131 Query: 224 SSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQ 283 +S D +++IW S P N Sbjct: 132 ASPDATIRIW--------------SVP-------------------------------NA 146 Query: 284 GLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISD-TAQHSMPFL 342 VQ H S++ L G +SSS+D+ + Q + +++D T+ S+ Sbjct: 147 SCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCA 206 Query: 343 NVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGD 402 HP F +MD++I + LK +R F GHS G S+AFS +G Y+ + Sbjct: 207 QFHPDGLIFGTGTMDSQIKIWDLK---ERTNVANFPGHS--GPITSIAFSENGYYLATAA 261 Query: 403 SKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVC 454 S + WD + +++ N + + + Q + + G +IY+C Sbjct: 262 DDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFD-QSGTYLALGGTDVQIYIC 312 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 46/212 (21%), Positives = 91/212 (42%), Gaps = 7/212 (3%) Query: 152 KKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKA 211 ++++ GH + T++ F P + L+ S D TI+IW + C++ + H + Sbjct: 104 EQILATLKGHTKKVTSVVFHP-SQDLVFSASPDATIRIWSV-PNASCVQVVRAHESAVTG 161 Query: 212 LRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLS--N 269 L LSSS D+ D +TG+V T++ ++ + +P I G + Sbjct: 162 LSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMD 221 Query: 270 SKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIK 329 S+I +D + N V + H I ++ + +G ++++D +V++W+ + K Sbjct: 222 SQIKIWDLKERTN---VANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFK 278 Query: 330 QISDTAQHSMPFLNVHPSQNYFCAQSMDNRIY 361 + + L S Y D +IY Sbjct: 279 TLQLDNNFEVKSLIFDQSGTYLALGGTDVQIY 310 >5Z56-q nrPDB Length = 504 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 66/292 (22%), Positives = 114/292 (39%), Gaps = 53/292 (18%) Query: 164 GTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLS 223 G AL P + IL+GG D + ++D + + L +GH K + ++ F S Sbjct: 223 GILALDLCPSDTNKILTGGADKNVVVFDKSSE-QILATLKGHTKKVTSVVFHPSQDLVFS 281 Query: 224 SSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQ 283 +S D +++IW S P N Sbjct: 282 ASPDATIRIW--------------SVP-------------------------------NA 296 Query: 284 GLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISD-TAQHSMPFL 342 VQ H S++ L G +SSS+D+ + Q + +++D T+ S+ Sbjct: 297 SCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCA 356 Query: 343 NVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGD 402 HP F +MD++I + LK +R F GHS G S+AFS +G Y+ + Sbjct: 357 QFHPDGLIFGTGTMDSQIKIWDLK---ERTNVANFPGHS--GPITSIAFSENGYYLATAA 411 Query: 403 SKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVC 454 S + WD + +++ N + + + Q + + G +IY+C Sbjct: 412 DDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFD-QSGTYLALGGTDVQIYIC 462 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 39/172 (22%), Positives = 80/172 (46%), Gaps = 7/172 (4%) Query: 152 KKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKA 211 ++++ GH + T++ F P + L+ S D TI+IW + C++ + H + Sbjct: 254 EQILATLKGHTKKVTSVVFHP-SQDLVFSASPDATIRIWSV-PNASCVQVVRAHESAVTG 311 Query: 212 LRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFI--VGLSN 269 L LSSS D+ D +TG+V T++ ++ + +P I G + Sbjct: 312 LSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMD 371 Query: 270 SKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321 S+I +D + N V + H I ++ + +G ++++D +V++W+ Sbjct: 372 SQIKIWDLKERTN---VANFPGHSGPITSIAFSENGYYLATAADDSSVKLWD 420 >6N9G-C nrPDB Length = 353 Score = 61.6 bits (148), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 62/257 (24%), Positives = 109/257 (42%), Gaps = 27/257 (10%) Query: 167 ALKFLPKTGHLILSGGNDHTIKIWDFYHD-----YECLRDFQGHNKPIKALRFTEDCQSF 221 A + P +G I GG D+ ++ D + H + A FT Sbjct: 110 ACAYAP-SGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQI 168 Query: 222 LSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHE----FIVGLSNSKILHYDD 277 L++S D + +WD E+G++ H + ADV P E F+ G + K + +D Sbjct: 169 LTASGDGTCALWDVESGQLLQSFHGHG--ADVLCLDLAPSETGNTFVSGGCDKKAMVWDM 226 Query: 278 RVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQH 337 R + VQ ++ H S + +++Y+P G F S S+D T R+++ + + ++++ ++ Sbjct: 227 RSGQ---CVQAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRAD---REVAIYSKE 280 Query: 338 SMPF----LNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSG 393 S+ F ++ S A D Y+ ++ K I GH + +L S Sbjct: 281 SIIFGASSVDFSLSGRLLFAGYND---YTINVWDVLKGSRVSILFGHENRVS--TLRVSP 335 Query: 394 DGRYICSGDSKSRLFTW 410 DG CSG L W Sbjct: 336 DGTAFCSGSWDHTLRVW 352 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 38/174 (21%), Positives = 80/174 (45%), Gaps = 13/174 (7%) Query: 153 KVIRNYPGHPEGTTALKFLP-KTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKA 211 ++++++ GH L P +TG+ +SGG D +WD +C++ F+ H + + Sbjct: 186 QLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDM-RSGQCVQAFETHESDVNS 244 Query: 212 LRFTEDCQSFLSSSFDRSVKIWDTETGK-----VKTRLHLNSTPADVESRPTNPHEFIVG 266 +R+ +F S S D + +++D + K + ++ D + G Sbjct: 245 VRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDF---SLSGRLLFAG 301 Query: 267 LSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 ++ I +D ++ +++ +S+ L+ PDG+ F S S D T+R+W Sbjct: 302 YNDYTINVWDVLKGSRVSILFGHENRVST---LRVSPDGTAFCSGSWDHTLRVW 352 Score = 34.3 bits (77), Expect = 0.13, Method: Compositional matrix adjust. Identities = 39/214 (18%), Positives = 86/214 (40%), Gaps = 9/214 (4%) Query: 200 RDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTN 259 R +GH + + + +D + +SSS D V +WD+ T + + + T + + Sbjct: 57 RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 116 Query: 260 PHEFIVGLSNSKILHYDDRVSENQGLV---QTYDHHLSSILALKYFPDGSKFISSSEDKT 316 G ++K Y +N+ + ++ H + + A + + +++S D T Sbjct: 117 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT 176 Query: 317 VRIWENQINVPIKQISDTAQHSMPFLNVHPSQ--NYFCAQSMDNRIYSFSLKPKYKRHPK 374 +W+ + ++ + L++ PS+ N F + D + + ++ Sbjct: 177 CALWDVESGQLLQSFHGHGADVLC-LDLAPSETGNTFVSGGCDKKAMVWDMRSG---QCV 232 Query: 375 KIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLF 408 + F+ H S + SGD S D+ RL+ Sbjct: 233 QAFETHESDVNSVRYYPSGDAFASGSDDATCRLY 266 >4V8M-A7 nrPDB Length = 318 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 55/259 (21%), Positives = 106/259 (40%), Gaps = 40/259 (15%) Query: 171 LPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSV 230 L G+ +S DH++++W+ + +C F GH K + ++ F+ D + +S D ++ Sbjct: 75 LSNNGNFAVSASWDHSLRLWNL-QNGQCQYKFLGHTKDVLSVAFSPDNRQIVSGGRDNAL 133 Query: 231 KIWDT--ETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQT 288 ++W+ E +R + V P+ IV ++ D + LV Sbjct: 134 RVWNVKGECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGR--LVTD 191 Query: 289 YDHHLSSILALKYFPDGSKFISSSEDKTVRIW---------ENQINVPIKQISDTAQHSM 339 H + + ++ PDGS SS +D R+W E PI QI Sbjct: 192 LKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPINQIC------- 244 Query: 340 PFLNVHPSQNYFCAQS--------MDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAF 391 P++ + CA + ++N+ L P+++ K + + +S+A+ Sbjct: 245 ----FSPNRYWMCAATEKGIRIFDLENKDIIVELAPEHQGSKKIVPE-------CVSIAW 293 Query: 392 SGDGRYICSGDSKSRLFTW 410 S DG + SG + + + W Sbjct: 294 SADGSTLYSGYTDNVIRVW 312 Score = 29.6 bits (65), Expect = 3.1, Method: Compositional matrix adjust. Identities = 37/151 (24%), Positives = 69/151 (45%), Gaps = 28/151 (18%) Query: 273 LHYDDRVSENQGLVQTYDHHLSSILALKYFPD-GSKFISSSEDKTVRIW---------EN 322 + Y+ +++ ++G V + LA P+ +K +S+S DKT+ W E Sbjct: 3 VAYEGQLTGHRGWVTS--------LACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSEC 54 Query: 323 QINVPIKQISDTAQHSMPFLNVHPSQN--YFCAQSMDNRIYSFSLKPKYKRHPKKIFKGH 380 +P +++ HS +V S N + + S D+ + ++L+ ++ F GH Sbjct: 55 SYGLPDRRLEG---HSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYK---FLGH 108 Query: 381 SSAGYGISLAFSGDGRYICSGDSKSRLFTWD 411 + +S+AFS D R I SG + L W+ Sbjct: 109 TKDV--LSVAFSPDNRQIVSGGRDNALRVWN 137 >5NZU-C nrPDB Length = 905 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 37/149 (24%), Positives = 72/149 (48%), Gaps = 4/149 (2%) Query: 174 TGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFT-EDCQSFLSSSFDRSVKI 232 T IL+ +D IK+WD+ + C + F+GH + + +D F S+S DR++K+ Sbjct: 110 TQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKV 169 Query: 233 WDTETGKVKTRLHLNSTPAD-VESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDH 291 W + L + + ++ +++ ++ +++ D +N+ VQT + Sbjct: 170 WQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDY--QNKTCVQTLEG 227 Query: 292 HLSSILALKYFPDGSKFISSSEDKTVRIW 320 H ++ + P+ I+ SED TVRIW Sbjct: 228 HAQNVSCASFHPELPIIITGSEDGTVRIW 256 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 39/203 (19%), Positives = 78/203 (38%), Gaps = 7/203 (3%) Query: 221 FLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVS 280 L+S ++ SV +W+ ET + + P + + G + +I ++ Sbjct: 30 MLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTL 89 Query: 281 ENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMP 340 E V ++ H I + P ++SS+D +++W+ Q+ + H + Sbjct: 90 ER---VHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVM 146 Query: 341 FLNVHPS-QNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYIC 399 + ++P N F + S+D I + L P +GH I GD Y+ Sbjct: 147 QIVINPKDNNQFASASLDRTIKVWQLGSS---SPNFTLEGHEKGVNCIDYYSGGDKPYLI 203 Query: 400 SGDSKSRLFTWDWNTSRLLNNIK 422 SG + WD+ + ++ Sbjct: 204 SGADDRLVKIWDYQNKTCVQTLE 226 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 22/87 (25%), Positives = 46/87 (52%), Gaps = 2/87 (2%) Query: 160 GHPEGTTALKFLPKTGH-LILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDC 218 GH +G + + ++SG +D +KIWD Y + C++ +GH + + F + Sbjct: 183 GHEKGVNCIDYYSGGDKPYLISGADDRLVKIWD-YQNKTCVQTLEGHAQNVSCASFHPEL 241 Query: 219 QSFLSSSFDRSVKIWDTETGKVKTRLH 245 ++ S D +V+IW + T ++++ L+ Sbjct: 242 PIIITGSEDGTVRIWHSSTYRLESTLN 268 >3JB9-L nrPDB Length = 340 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 64/291 (21%), Positives = 124/291 (42%), Gaps = 14/291 (4%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQ 219 GH +F P +G SGG D I +W+ + D + G I L+++ D + Sbjct: 48 GHTAEVLVARFDP-SGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQWSRDSR 106 Query: 220 SFLSSSFDRSVKIWDTETGKVKTRLHL-NSTPADVESRPTNPHEFIVGLSNSKILHYDDR 278 SS D + WD +G+ K R H ++ + E + +S+ + D Sbjct: 107 VVYCSSSDTHLMSWDAVSGQ-KIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWD- 164 Query: 279 VSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHS 338 S ++ ++T + + A+ G++ D ++IW+ + N + + Sbjct: 165 -SRSKDCIKTIEEKY-PLTAVAIAQQGTQVFIGGIDGAIKIWDLR-NNHCSHVLKGHKDI 221 Query: 339 MPFLNVHPSQNYFCAQSMDNRIYSFSLKP-KYKRHPKKIFKG--HSSAGYGISLAFSGDG 395 + L + + + SMDN + F +KP + +IF+G H + +A+S + Sbjct: 222 ITSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNS 281 Query: 396 RYICSGDSKSRLFTWDWNTSRLLNNIKIPGNK-PITQVDWHPQETSKVICS 445 R++ +G S ++ W T L +PG++ + VD+HP + + CS Sbjct: 282 RFVGAGSSDKNVYVWS-ATGDL--RYVLPGHEGSVNHVDFHPHQDIILSCS 329 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 46/216 (21%), Positives = 88/216 (40%), Gaps = 17/216 (7%) Query: 155 IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRF 214 IR + GH AL L L+ S +D T+K+WD +C++ + P+ A+ Sbjct: 128 IRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWD-SRSKDCIKTIE-EKYPLTAVAI 185 Query: 215 TEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLN-------STPADVESRPTNPHEFIVGL 267 + D ++KIWD L + + D S +N + V + Sbjct: 186 AQQGTQVFIGGIDGAIKIWDLRNNHCSHVLKGHKDIITSLAISKDGSSLLSNSMDNTVRI 245 Query: 268 SNSKILHYDDR-VSENQGLVQTYDHHLSSILALKYFPDGSKFI-SSSEDKTVRIWENQIN 325 + K R + +G + +H+L + + S+F+ + S DK V +W + Sbjct: 246 FDVKPFASAQRQLQIFEGAIHGQEHNLLGV----AWSRNSRFVGAGSSDKNVYVWSATGD 301 Query: 326 VPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIY 361 ++ + + S+ ++ HP Q+ + S D I+ Sbjct: 302 --LRYVLPGHEGSVNHVDFHPHQDIILSCSSDRTIF 335 >5NNZ-B nrPDB Length = 415 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 48/178 (26%), Positives = 80/178 (44%), Gaps = 17/178 (9%) Query: 171 LPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTED-CQSFLSSSFDRS 229 L K+G ++G D T K+WD E L +GH + A+ F + SFD++ Sbjct: 100 LNKSGSCFITGSYDRTCKLWDTASGEE-LNTLEGHRNVVYAIAFNNPYGDKIATGSFDKT 158 Query: 230 VKIWDTETGKV--KTRLHLNSTPADVESRPTNPHEFIV--GLSNSKILHYDDRVSENQGL 285 K+W ETGK R H A++ NP +V G ++ +D + E Sbjct: 159 CKLWSVETGKCYHTFRGH----TAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEE--- 211 Query: 286 VQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE----NQINVPIKQISDTAQHSM 339 V T H + I++L + G + I+ S D TV +W+ ++N+ I ++ + S Sbjct: 212 VYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASF 269 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 60/270 (22%), Positives = 99/270 (36%), Gaps = 14/270 (5%) Query: 155 IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRF 214 + GH A+ F G I +G D T K+W +C F+GH I L F Sbjct: 127 LNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSV-ETGKCYHTFRGHTAEIVCLSF 185 Query: 215 TEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILH 274 + S D + K+WD + G+ L +S S T+ I G + ++ Sbjct: 186 NPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVV 245 Query: 275 YDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDT 334 +D V H + I + + D S ++ S DKT ++W+ K ++ Sbjct: 246 WDADTGRK---VNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNG---KCVATL 299 Query: 335 AQHSMPFLN--VHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFS 392 H L+ + S D FS + K I K G ++F+ Sbjct: 300 TGHDDEILDSCFDYTGKLIATASADGTARIFSAATR-----KCIAKLEGHEGEISKISFN 354 Query: 393 GDGRYICSGDSKSRLFTWDWNTSRLLNNIK 422 G ++ +G S WD T + L ++ Sbjct: 355 PQGNHLLTGSSDKTARIWDAQTGQCLQVLE 384 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 46/203 (22%), Positives = 75/203 (36%), Gaps = 47/203 (23%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQ 219 GH +L F +G I++G DHT+ +WD + + GH I + F DC Sbjct: 217 GHSAEIISLSF-NTSGDRIITGSFDHTVVVWDADTGRK-VNILIGHCAEISSASFNWDCS 274 Query: 220 SFLSSSFDRSVKIWDTETGKVKTRLH-----------------LNSTPADVESR------ 256 L+ S D++ K+WD GK L + + AD +R Sbjct: 275 LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAAT 334 Query: 257 -----------------PTNP--HEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSIL 297 NP + + G S+ +D + + +Q + H I Sbjct: 335 RKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQ---CLQVLEGHTDEIF 391 Query: 298 ALKYFPDGSKFISSSEDKTVRIW 320 + + G+ I+ S+D T RIW Sbjct: 392 SCAFNYKGNIVITGSKDNTCRIW 414 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 47/228 (20%), Positives = 86/228 (37%), Gaps = 54/228 (23%) Query: 194 HDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADV 253 H + + + H P+ + + F++ S+DR+ K+WDT +G+ LN Sbjct: 80 HTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGE-----ELN------ 128 Query: 254 ESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKY-FPDGSKFISSS 312 T + H + + A+ + P G K + S Sbjct: 129 ----------------------------------TLEGHRNVVYAIAFNNPYGDKIATGS 154 Query: 313 EDKTVRIWENQINVPIKQI-SDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKR 371 DKT ++W + TA+ + L+ +P SMD + ++ + Sbjct: 155 FDKTCKLWSVETGKCYHTFRGHTAE--IVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEV 212 Query: 372 HPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLN 419 + +GHS+ ISL+F+ G I +G + WD +T R +N Sbjct: 213 YT---LRGHSAE--IISLSFNTSGDRIITGSFDHTVVVWDADTGRKVN 255 >5OPT-p nrPDB Length = 318 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 60/274 (21%), Positives = 109/274 (39%), Gaps = 41/274 (14%) Query: 156 RNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFT 215 R GH + + L G +S DH++++W+ C F GH K + ++ F+ Sbjct: 61 RRLEGHSAFVSDVA-LSNNGDFAVSASWDHSLRLWNLQTGV-CQHKFLGHTKDVLSVTFS 118 Query: 216 EDCQSFLSSSFDRSVKIWDTETGKVKT--RLHLNSTPADVESRPTNPHEFIVGLSNSKIL 273 D + +S D ++++W+ + + T R + V P+ IV ++ Sbjct: 119 PDNRQIVSGGRDNALRVWNVKGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLV 178 Query: 274 HYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW---------ENQI 324 D S L+ H + I ++ PDGS SS +D R+W E Sbjct: 179 KVWDIASGR--LLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAA 236 Query: 325 NVPIKQISDTAQHSMPFLNVHPSQNYFCAQS--------MDNRIYSFSLKPKYKRHPKKI 376 PI QI P++ + CA + ++N+ L P+ ++ KK Sbjct: 237 GAPINQIC-----------FSPNRYWMCAATEKGIRIFDLENKDVIVELAPEAQQKSKKT 285 Query: 377 FKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTW 410 + +S+A+S DG + SG + + + W Sbjct: 286 PE-------CMSIAWSADGNTLYSGYTDNVIRVW 312 >3DM0-A nrPDB Length = 694 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 61/259 (23%), Positives = 106/259 (40%), Gaps = 26/259 (10%) Query: 171 LPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSV 230 L G LSG D +++WD R F GH K + ++ F+ D + +S+S DR++ Sbjct: 438 LSSDGQFALSGSWDGELRLWDLAAGVST-RRFVGHTKDVLSVAFSLDNRQIVSASRDRTI 496 Query: 231 KIWDTETGKVKTRLHLNST-----PADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGL 285 K+W+T G+ K + + V P IV S K + + N L Sbjct: 497 KLWNT-LGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNL--SNCKL 553 Query: 286 VQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQI-SDTAQHSMPFLNV 344 T H + + PDGS S +D V +W+ + + +++ H++ F Sbjct: 554 RSTLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLEANSVIHALCF--- 610 Query: 345 HPSQNYFCAQS--------MDNRIYSFSLKPKYKRHPKKIFKGHSSAG-----YGISLAF 391 P++ + CA + ++++ LK K +K +A Y SL + Sbjct: 611 SPNRYWLCAATEHGIKIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKVIYCTSLNW 670 Query: 392 SGDGRYICSGDSKSRLFTW 410 S DG + SG + + W Sbjct: 671 SADGSTLFSGYTDGVIRVW 689 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 56/273 (20%), Positives = 122/273 (44%), Gaps = 20/273 (7%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECL----RDFQGHNKPIKALRFT 215 H + TA+ +I+S D +I +W D + R GH+ ++ + + Sbjct: 380 AHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDVVLS 439 Query: 216 EDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHY 275 D Q LS S+D +++WD G V TR + T + + + IV S + + Sbjct: 440 SDGQFALSGSWDGELRLWDLAAG-VSTRRFVGHTKDVLSVAFSLDNRQIVSASRDRTIKL 498 Query: 276 DDRVSENQGLV-QTYDHHLSSILALKYFPDGSK--FISSSEDKTVRIWENQINVPIKQIS 332 + + E + + + + H + +++ P+ + +S+S DKTV++W N N ++ S Sbjct: 499 WNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVW-NLSNCKLR--S 555 Query: 333 DTAQHS--MPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLA 390 A H+ + + V P + + D + + L KK++ +++ +L Sbjct: 556 TLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLA-----EGKKLYSLEANSVIH-ALC 609 Query: 391 FSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKI 423 FS + ++C+ ++ + WD + ++ ++K+ Sbjct: 610 FSPNRYWLCAA-TEHGIKIWDLESKSIVEDLKV 641 >5OV3-A nrPDB Length = 381 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 74/350 (21%), Positives = 132/350 (37%), Gaps = 92/350 (26%) Query: 156 RNYPGHPEGTTALKFLPKT------GHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPI 209 +NYP +GT + T G L+ G ND I IWDF + H P+ Sbjct: 12 QNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLT-RGIAKIISAHIHPV 70 Query: 210 KALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVG--- 266 +L ++ D +S+S D V WD +G R S V+ P + ++ +V Sbjct: 71 CSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMK 130 Query: 267 -------LSNSK--ILHYDDRV----------------------------SENQGLVQTY 289 LS+SK +L DD +++Q LV ++ Sbjct: 131 SAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASF 190 Query: 290 -----DHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNV 344 + ++I ++++ GS F+ ++ D+ +R+++ ++I + P Sbjct: 191 RVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDG------REILTCGRDGEP---- 240 Query: 345 HPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSK 404 P Q L+ R P K FSGDG YI +G ++ Sbjct: 241 EPMQK---------------LQDLVNRTPWK------------KCCFSGDGEYIVAGSAR 273 Query: 405 S-RLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYV 453 L+ W+ + L+ + + + V WHP +I S ++G + + Sbjct: 274 QHALYIWEKSIGNLVKILHGTRGELLLDVAWHP--VRPIIASISSGVVSI 321 >5LCW-Q nrPDB Length = 374 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 46/180 (25%), Positives = 87/180 (48%), Gaps = 25/180 (13%) Query: 155 IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFY---HDYECLRDFQGHNKPIKA 211 + GH + L++ P HL SGGND+ + +W + L+ F H +KA Sbjct: 177 VATLSGHSQEVCGLRWAPDGRHLA-SGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKA 235 Query: 212 LRFTEDCQSFLSS---SFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPH--EFIVG 266 + + + L++ + DR ++IW+ +G + + +S V S +PH E I G Sbjct: 236 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS---QVCSILWSPHYKELISG 292 Query: 267 --LSNSKILHYD----DRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 + ++++ + +V+E +G H S +L+L PDG+ S++ D+T+R+W Sbjct: 293 HGFAQNQLVIWKYPTMAKVAELKG-------HTSRVLSLTMSPDGATVASAAADETLRLW 345 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 35/145 (24%), Positives = 63/145 (43%), Gaps = 7/145 (4%) Query: 178 ILSGGNDHTIKIWDFYH-DYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTE 236 +L+ D+++ +W D L + + I ++ + ++ + V++WD + Sbjct: 72 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ 131 Query: 237 TGKVKTRL-HLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSS 295 K RL ++ S A V S N + G + I H+D RV+E+ V T H Sbjct: 132 QQK---RLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHH--VATLSGHSQE 186 Query: 296 ILALKYFPDGSKFISSSEDKTVRIW 320 + L++ PDG S D V +W Sbjct: 187 VCGLRWAPDGRHLASGGNDNLVNVW 211 >3ODT-A nrPDB Length = 313 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 52/208 (25%), Positives = 100/208 (48%), Gaps = 19/208 (9%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPI---KALRFTE 216 GH +L F +++SG D T K+W + + + Q HN + K + F+E Sbjct: 102 GHQGNVCSLSFQDG---VVISGSWDKTAKVW---KEGSLVYNLQAHNASVWDAKVVSFSE 155 Query: 217 DCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYD 276 + FL++S D+++K+W + +KT +++ + + H + SN ++ Sbjct: 156 N--KFLTASADKTIKLWQNDK-VIKTFSGIHNDVVRHLAVVDDGH--FISCSNDGLIKLV 210 Query: 277 DRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQ 336 D + + +++TY+ H S + +K P+G +S ED+TVRIW + N +KQ+ Sbjct: 211 DMHTGD--VLRTYEGHESFVYCIKLLPNG-DIVSCGEDRTVRIWSKE-NGSLKQVITLPA 266 Query: 337 HSMPFLNVHPSQNYFCAQSMDNRIYSFS 364 S+ ++ + + S DN + FS Sbjct: 267 ISIWSVDCMSNGDIIVGSS-DNLVRIFS 293 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 28/102 (27%), Positives = 47/102 (46%), Gaps = 3/102 (2%) Query: 145 SFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQG 204 + + + KVI+ + G + GH I S ND IK+ D H + LR ++G Sbjct: 166 TIKLWQNDKVIKTFSGIHNDVVRHLAVVDDGHFI-SCSNDGLIKLVDM-HTGDVLRTYEG 223 Query: 205 HNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHL 246 H + ++ + +S DR+V+IW E G +K + L Sbjct: 224 HESFVYCIKLLPN-GDIVSCGEDRTVRIWSKENGSLKQVITL 264 Score = 32.0 bits (71), Expect = 0.52, Method: Compositional matrix adjust. Identities = 29/103 (28%), Positives = 48/103 (46%), Gaps = 7/103 (6%) Query: 307 KFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLK 366 KF+++S DKT+++W+N + IK S + L V +F + S D I L Sbjct: 157 KFLTASADKTIKLWQN--DKVIKTFSGIHNDVVRHLAV-VDDGHFISCSNDGLI---KLV 210 Query: 367 PKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFT 409 + + ++GH S Y I L +GD C D R+++ Sbjct: 211 DMHTGDVLRTYEGHESFVYCIKLLPNGD-IVSCGEDRTVRIWS 252 >4N14-A nrPDB Length = 314 Score = 58.2 bits (139), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 46/180 (25%), Positives = 87/180 (48%), Gaps = 25/180 (13%) Query: 155 IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFY---HDYECLRDFQGHNKPIKA 211 + GH + L++ P HL SGGND+ + +W + L+ F H +KA Sbjct: 139 VATLSGHSQEVCGLRWAPDGRHLA-SGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKA 197 Query: 212 LRFTEDCQSFLSS---SFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPH--EFIVG 266 + + + L++ + DR ++IW+ +G + + +S V S +PH E I G Sbjct: 198 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS---QVCSILWSPHYKELISG 254 Query: 267 --LSNSKILHYD----DRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 + ++++ + +V+E +G H S +L+L PDG+ S++ D+T+R+W Sbjct: 255 HGFAQNQLVIWKYPTMAKVAELKG-------HTSRVLSLTMSPDGATVASAAADETLRLW 307 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 35/145 (24%), Positives = 63/145 (43%), Gaps = 7/145 (4%) Query: 178 ILSGGNDHTIKIWDFYH-DYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTE 236 +L+ D+++ +W D L + + I ++ + ++ + V++WD + Sbjct: 34 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ 93 Query: 237 TGKVKTRL-HLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSS 295 K RL ++ S A V S N + G + I H+D RV+E+ V T H Sbjct: 94 QQK---RLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHH--VATLSGHSQE 148 Query: 296 ILALKYFPDGSKFISSSEDKTVRIW 320 + L++ PDG S D V +W Sbjct: 149 VCGLRWAPDGRHLASGGNDNLVNVW 173 >4GGA-A nrPDB Length = 420 Score = 58.2 bits (139), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 46/180 (25%), Positives = 87/180 (48%), Gaps = 25/180 (13%) Query: 155 IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFY---HDYECLRDFQGHNKPIKA 211 + GH + L++ P HL SGGND+ + +W + L+ F H +KA Sbjct: 223 VATLSGHSQEVCGLRWAPDGRHLA-SGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKA 281 Query: 212 LRFTEDCQSFLSS---SFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPH--EFIVG 266 + + + L++ + DR ++IW+ +G + + +S V S +PH E I G Sbjct: 282 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS---QVCSILWSPHYKELISG 338 Query: 267 --LSNSKILHYD----DRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 + ++++ + +V+E +G H S +L+L PDG+ S++ D+T+R+W Sbjct: 339 HGFAQNQLVIWKYPTMAKVAELKG-------HTSRVLSLTMSPDGATVASAAADETLRLW 391 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 35/145 (24%), Positives = 63/145 (43%), Gaps = 7/145 (4%) Query: 178 ILSGGNDHTIKIWDFYH-DYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTE 236 +L+ D+++ +W D L + + I ++ + ++ + V++WD + Sbjct: 118 VLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ 177 Query: 237 TGKVKTRL-HLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSS 295 K RL ++ S A V S N + G + I H+D RV+E+ V T H Sbjct: 178 QQK---RLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHH--VATLSGHSQE 232 Query: 296 ILALKYFPDGSKFISSSEDKTVRIW 320 + L++ PDG S D V +W Sbjct: 233 VCGLRWAPDGRHLASGGNDNLVNVW 257 >5G04-R nrPDB Length = 499 Score = 57.8 bits (138), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 46/180 (25%), Positives = 87/180 (48%), Gaps = 25/180 (13%) Query: 155 IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFY---HDYECLRDFQGHNKPIKA 211 + GH + L++ P HL SGGND+ + +W + L+ F H +KA Sbjct: 302 VATLSGHSQEVCGLRWAPDGRHLA-SGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKA 360 Query: 212 LRFTEDCQSFLSS---SFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPH--EFIVG 266 + + + L++ + DR ++IW+ +G + + +S V S +PH E I G Sbjct: 361 VAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHS---QVCSILWSPHYKELISG 417 Query: 267 --LSNSKILHYD----DRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 + ++++ + +V+E +G H S +L+L PDG+ S++ D+T+R+W Sbjct: 418 HGFAQNQLVIWKYPTMAKVAELKG-------HTSRVLSLTMSPDGATVASAAADETLRLW 470 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 56/250 (22%), Positives = 101/250 (40%), Gaps = 22/250 (8%) Query: 78 ETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDV 137 E SQ + T+KE Q + AL + D E+ ++ +S + + YQ R + Sbjct: 102 ENSQ-TPTKKEHQKAW--ALNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATP 158 Query: 138 DLREERISFRCYLPKKV-----IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF 192 + + LP ++ IRN L + + +L+ D+++ +W Sbjct: 159 GSSRKTCRYIPSLPDRILDAPEIRN-------DYYLNLVDWSSGNVLAVALDNSVYLWSA 211 Query: 193 YH-DYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRL-HLNSTP 250 D L + + I ++ + ++ + V++WD + K RL ++ S Sbjct: 212 SSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQK---RLRNMTSHS 268 Query: 251 ADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFIS 310 A V S N + G + I H+D RV+E+ V T H + L++ PDG S Sbjct: 269 ARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHH--VATLSGHSQEVCGLRWAPDGRHLAS 326 Query: 311 SSEDKTVRIW 320 D V +W Sbjct: 327 GGNDNLVNVW 336 >5K1B-B nrPDB Length = 677 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 39/160 (24%), Positives = 71/160 (44%), Gaps = 13/160 (8%) Query: 170 FLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRS 229 L G ++S +D T+K+W+ + + C+ + H +KAL + +D + S+ DR Sbjct: 82 VLCCNGKTLISASSDTTVKVWNAHKGF-CMSTLRTHKDYVKALAYAKDKELVASAGLDRQ 140 Query: 230 VKIWDTETGKVKTRLHLNSTPADVESRPTNPHEF--------IVGLSNSKILH-YDDRVS 280 + +WD T T + T + + + + IV S K+L +D R Sbjct: 141 IFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTC 200 Query: 281 ENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 + H ++ AL DG++ +S S D T+R+W Sbjct: 201 AK---LMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLW 237 Score = 35.4 bits (80), Expect = 0.050, Method: Compositional matrix adjust. Identities = 24/108 (22%), Positives = 44/108 (40%), Gaps = 4/108 (3%) Query: 146 FRCYLPKKV--IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQ 203 R + P+ + GH + AL L + G LSG +D TI++W C+ ++ Sbjct: 192 LRVWDPRTCAKLMKLKGHTDNVKAL-LLNRDGTQCLSGSSDGTIRLWSLGQQ-RCIATYR 249 Query: 204 GHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPA 251 H++ + AL+ + S DR + D ++ + P Sbjct: 250 VHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPV 297 Score = 32.7 bits (73), Expect = 0.31, Method: Compositional matrix adjust. Identities = 30/143 (20%), Positives = 56/143 (39%), Gaps = 9/143 (6%) Query: 286 VQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVH 345 + + +HH + + +G IS+S D TV++W + + T + + L Sbjct: 68 IASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLR-THKDYVKALAYA 126 Query: 346 PSQNYFCAQSMDNRIYSF------SLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYIC 399 + + +D +I+ + +L G+ + Y SLA + G I Sbjct: 127 KDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIY--SLAMNQLGTIIV 184 Query: 400 SGDSKSRLFTWDWNTSRLLNNIK 422 SG ++ L WD T L +K Sbjct: 185 SGSTEKVLRVWDPRTCAKLMKLK 207 >4V7E-Bg nrPDB Length = 380 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 45/171 (26%), Positives = 74/171 (43%), Gaps = 12/171 (7%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQ 219 GH +L ++ +SG D T+++WD +R + GH I +++F D Q Sbjct: 203 GHTADVLSLSINSLNANMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINSVKFFPDGQ 262 Query: 220 SFLSSSFDRSVKIWDTETG---KVKTR---LHLNSTPADVE-SRPTNPHEFIVGLSNSKI 272 F + S D + +++D TG +V R + N P + + G SN Sbjct: 263 RFGTGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDC 322 Query: 273 LHYDDRVSE---NQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 +D ++E N G +Q + H I L DGS + S DK ++IW Sbjct: 323 YVWDTLLAEMVLNLGTLQ--NSHEGRISCLGLSSDGSALCTGSWDKNLKIW 371 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 60/267 (22%), Positives = 108/267 (40%), Gaps = 59/267 (22%) Query: 169 KFLPKTGHLILSGGNDHTIKIWDFYHDYE------CLRDFQGHNKPIKALRFTEDCQS-F 221 F P G + GG D I++ + R GH + ++ D ++ Sbjct: 115 AFAPN-GQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRL 173 Query: 222 LSSSFDRSVKIWDTETGKVKTRLHLNSTP----ADVES---RPTNPHEFIVGLSNSKILH 274 ++ S D++ +WD TG+ + + + P ADV S N + FI G ++ + Sbjct: 174 ITGSGDQTCVLWDVTTGQ-RISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRL 232 Query: 275 YDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDT 334 +D R++ V+TY H I ++K+FPDG +F + S+D T R+++ + Sbjct: 233 WDLRITSRA--VRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTG--------- 281 Query: 335 AQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGD 394 H + N P +N DN + + S+AFS Sbjct: 282 --HQLQVYNREPDRN-------DNELPIVT-----------------------SVAFSIS 309 Query: 395 GRYICSGDSKSRLFTWDWNTSRLLNNI 421 GR + +G S + WD + ++ N+ Sbjct: 310 GRLLFAGYSNGDCYVWDTLLAEMVLNL 336 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 54/231 (23%), Positives = 95/231 (41%), Gaps = 26/231 (11%) Query: 195 DYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVE 254 D C R QGH+ + +L +T + +S+S D + +W+ T + + L+ P +E Sbjct: 55 DLVCCRTLQGHSGKVYSLDWTPEKNWIVSASQDGRLIVWNALTSQKTHAIKLH-CPWVME 113 Query: 255 S--RPTNPHEFIVGL-SNSKILHYDDRVSE--NQGLVQTYDHHLSSILALKYFPDG-SKF 308 P GL S I + + N + + H + +Y PD ++ Sbjct: 114 CAFAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRL 173 Query: 309 ISSSEDKTVRIWE----NQINV-----PIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNR 359 I+ S D+T +W+ +I++ P +D S+ LN N F + S D Sbjct: 174 ITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNA----NMFISGSCDTT 229 Query: 360 IYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSG--DSKSRLF 408 + + L+ + + + GH G S+ F DG+ +G D RLF Sbjct: 230 VRLWDLRITSR--AVRTYHGHE--GDINSVKFFPDGQRFGTGSDDGTCRLF 276 >6EMK-B nrPDB Length = 303 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 49/237 (20%), Positives = 102/237 (43%), Gaps = 19/237 (8%) Query: 221 FLSSSFDRSVKIWDTETGKV-KTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRV 279 +S+ +D +++ W+ TG +T H +S +E TN + + + + YD R Sbjct: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLE--ITNDKKLLATAGHQNVRLYDIRT 62 Query: 280 SENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSM 339 + N V +++ H ++ ++ + D ++SSED T+++W+ V I +H+ Sbjct: 63 T-NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWD----VRSPSIPRNYKHNA 117 Query: 340 PF--LNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRY 397 P + +HP+Q + D I + L H S SL+ + DG Sbjct: 118 PVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQ----SLSMASDGSM 173 Query: 398 ICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVC 454 + + ++K + W+ + N+ KP+T+ H ++++ S + C Sbjct: 174 LAAANTKGNCYVWE-----MPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATC 225 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 50/222 (22%), Positives = 94/222 (42%), Gaps = 12/222 (5%) Query: 202 FQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPH 261 F+GH + ++ F +D + ++SS D ++K+WD + + N+ +V P N Sbjct: 71 FEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVNEVVIHP-NQG 129 Query: 262 EFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321 E I + I +D + ENQ Q +S+ +L DGS +++ +WE Sbjct: 130 ELISCDRDGNIRIWD--LGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYVWE 187 Query: 322 --NQINVP-IKQISDTAQHSMPFLNVHPSQN--YFCAQSMDNRIYSFSLKPKYKRHPKKI 376 N + +K ++ HS + S + + S D+ +S+ +K + Sbjct: 188 MPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKL--ETT 245 Query: 377 FKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLL 418 GH + AFS D Y+ + S + WD +T ++ Sbjct: 246 LDGHQR--WVWDCAFSADSAYLVTASSDHYVRLWDLSTREIV 285 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 20/88 (22%), Positives = 37/88 (42%), Gaps = 1/88 (1%) Query: 153 KVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKAL 212 K + + H T + HL DHT ++W D++ GH + + Sbjct: 198 KPVTKFRAHSTYITRILLSSDVKHLATCSA-DHTARVWSIDDDFKLETTLDGHQRWVWDC 256 Query: 213 RFTEDCQSFLSSSFDRSVKIWDTETGKV 240 F+ D +++S D V++WD T ++ Sbjct: 257 AFSADSAYLVTASSDHYVRLWDLSTREI 284 >5Y88-O nrPDB Length = 451 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 45/149 (30%), Positives = 65/149 (43%), Gaps = 13/149 (8%) Query: 127 GYLYPPNDVDVDLR-------EERISFRCYLPKK--VIRNYPGHPEGTTALKFLPKTGHL 177 G++ DV V R E + +C+ +K +IR+Y GH G + P T L Sbjct: 180 GHVMTVRDVAVSDRHPYLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHP-TLDL 238 Query: 178 ILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTET 237 I + G D IK+WD + GH PI ++ T +SSS D +V++WD Sbjct: 239 IATAGRDSVIKLWDMRTRIPVIT-LVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVA 297 Query: 238 GKVKTRLHLNSTPADVESRPTNPHEFIVG 266 G KT L V + +P EF V Sbjct: 298 G--KTMKVLTHHKRSVRATALHPKEFSVA 324 Score = 48.1 bits (113), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 36/141 (25%), Positives = 71/141 (50%), Gaps = 8/141 (5%) Query: 191 DFYHDYECLRDFQGHNKPIKALRFTE-DCQSFLSSSFDRSVKIWDTETGKVKTRL--HLN 247 +++ ++ R GH ++ + D + F++ S D ++K+WD TGK+KT L H+ Sbjct: 124 EWHAPWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHV- 182 Query: 248 STPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSK 307 T DV +P+ F V S K + D + +NQ +++ Y HLS + + P Sbjct: 183 MTVRDVAVSDRHPYLFSV--SEDKTVKCWD-LEKNQ-IIRDYYGHLSGVRTVSIHPTLDL 238 Query: 308 FISSSEDKTVRIWENQINVPI 328 ++ D +++W+ + +P+ Sbjct: 239 IATAGRDSVIKLWDMRTRIPV 259 Score = 48.1 bits (113), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 54/219 (24%), Positives = 92/219 (42%), Gaps = 10/219 (4%) Query: 149 YLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKP 208 + P K+ R GH + P ++G ND T+K+WD + GH Sbjct: 126 HAPWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATG-KLKTTLAGHVMT 184 Query: 209 IKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRL--HLNSTPADVESRPTNPHEFIVG 266 ++ + ++ S S D++VK WD E ++ HL+ V PT G Sbjct: 185 VRDVAVSDRHPYLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRT-VSIHPTLDLIATAG 243 Query: 267 LSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINV 326 +S I +D R + V T H I ++ P + +SSS D TVR+W+ Sbjct: 244 -RDSVIKLWDMR---TRIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGK 299 Query: 327 PIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSL 365 +K ++ + S+ +HP + + A + + I S+ L Sbjct: 300 TMKVLTH-HKRSVRATALHPKE-FSVASACTDDIRSWGL 336 >5UZ7-B nrPDB Length = 351 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 41/152 (26%), Positives = 75/152 (49%), Gaps = 9/152 (5%) Query: 174 TGHLILSGGNDHTIKIWDFYH---DYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSV 230 +G+ + GG D+ I++ + R+ GH + RF +D Q ++SS D + Sbjct: 119 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQ-IVTSSGDTTC 177 Query: 231 KIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLV-QTY 289 +WD ETG+ T ++ S + F+ G ++ +D R +G+ QT+ Sbjct: 178 ALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVR----EGMCRQTF 233 Query: 290 DHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321 H S I A+ +FP+G+ F + S+D T R+++ Sbjct: 234 TGHESDINAICFFPNGNAFATGSDDATCRLFD 265 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 48/210 (22%), Positives = 83/210 (39%), Gaps = 6/210 (2%) Query: 200 RDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDT-ETGKVKTRLHLNSTPADVESRPT 258 R +GH I A+ + D + +S+S D + IWD+ T KV +S P+ Sbjct: 60 RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPS 119 Query: 259 NPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVR 318 + GL N + Y+ + E V + L+ F D ++ ++SS D T Sbjct: 120 GNYVACGGLDNICSI-YNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCA 178 Query: 319 IWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFK 378 +W+ + + M L++ P F + + D + ++ R + F Sbjct: 179 LWDIETGQQTTTFTGHTGDVMS-LSLAPDTRLFVSGACDASAKLWDVREGMCR---QTFT 234 Query: 379 GHSSAGYGISLAFSGDGRYICSGDSKSRLF 408 GH S I +G+ S D+ RLF Sbjct: 235 GHESDINAICFFPNGNAFATGSDDATCRLF 264 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 22/72 (30%), Positives = 38/72 (52%), Gaps = 4/72 (5%) Query: 164 GTTALKFLPKTGHLILSGGNDHTIKIWD-FYHDYECLRDFQGHNKPIKALRFTEDCQSFL 222 G T++ F K+G L+L+G +D +WD D + GH+ + L T+D + Sbjct: 283 GITSVSF-SKSGRLLLAGYDDFNCNVWDALKADRAGV--LAGHDNRVSCLGVTDDGMAVA 339 Query: 223 SSSFDRSVKIWD 234 + S+D +KIW+ Sbjct: 340 TGSWDSFLKIWN 351 >6ID0-T nrPDB Length = 514 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 36/139 (25%), Positives = 68/139 (48%), Gaps = 7/139 (5%) Query: 196 YECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRL--HLNSTPADV 253 ++ R GH ++ + Q F++ S DR++KIWD +GK+K L H+++ + Sbjct: 194 WKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVI 253 Query: 254 ESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSE 313 S +P+ F G + ++ +D E +++ Y HLS++ L P ++ S Sbjct: 254 VST-RSPYLFSCG-EDKQVKCWD---LEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSR 308 Query: 314 DKTVRIWENQINVPIKQIS 332 D T RIW+ + + +S Sbjct: 309 DSTARIWDVRTKASVHTLS 327 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 65/268 (24%), Positives = 105/268 (39%), Gaps = 21/268 (7%) Query: 151 PKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIK 210 P K+ R GH + P ++G D TIKIWD L GH ++ Sbjct: 193 PWKLYRVISGHLGWVRCIAVEPG-NQWFVTGSADRTIKIWDLASGKLKL-SLTGHISTVR 250 Query: 211 ALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLN-STPADVESRPTNPHEFIVGLS- 268 + + S D+ VK WD E KV H + S ++ PT + +V S Sbjct: 251 GVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTI--DVLVTCSR 308 Query: 269 NSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPI 328 +S +D R + V T H +++ ++ + I+ S D T+R+W+ + Sbjct: 309 DSTARIWDVRTKAS---VHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWD-LVAGKT 364 Query: 329 KQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGI- 387 + + S+ + +HP F + S DN K + P F + S I Sbjct: 365 RVTLTNHKKSVRAVVLHPRHYTFASGSPDNI--------KQWKFPDGSFIQNLSGHNAII 416 Query: 388 -SLAFSGDGRYICSGDSKSRLFTWDWNT 414 +L + DG + SG + WDW T Sbjct: 417 NTLTVNSDG-VLVSGADNGTMHLWDWRT 443 Score = 35.8 bits (81), Expect = 0.044, Method: Compositional matrix adjust. Identities = 25/95 (26%), Positives = 42/95 (44%), Gaps = 4/95 (4%) Query: 161 HPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQS 220 H + A+ P+ H + G+ IK W F D +++ GHN I L D Sbjct: 371 HKKSVRAVVLHPR--HYTFASGSPDNIKQWKF-PDGSFIQNLSGHNAIINTLTVNSD-GV 426 Query: 221 FLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVES 255 +S + + ++ +WD TG R+H P ++S Sbjct: 427 LVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDS 461 >6QX9-4B nrPDB Length = 522 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 26/85 (30%), Positives = 43/85 (50%), Gaps = 1/85 (1%) Query: 152 KKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKA 211 ++ + P H T +KF P G+ +L+G D+T KIW + + L+ GH + Sbjct: 439 RRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWT-HPGWSPLKTLAGHEGKVMG 497 Query: 212 LRFTEDCQSFLSSSFDRSVKIWDTE 236 L + D Q + S+DR+ K+W E Sbjct: 498 LDISSDGQLIATCSYDRTFKLWMAE 522 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 56/255 (21%), Positives = 100/255 (39%), Gaps = 24/255 (9%) Query: 161 HPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQS 220 HP+ T +L PK +L S D ++K+W D E + D +GH + + + + Sbjct: 282 HPKSTVSLD--PKDVNLA-SCAADGSVKLWSLDSD-EPVADIEGHTVRVARVMWHPSGRF 337 Query: 221 FLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILH--YDDR 278 ++ +DRS ++WD E + LH V + + G +D R Sbjct: 338 LGTTCYDRSWRLWDLEAQ--EEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLR 395 Query: 279 VSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQ-----INVPIKQISD 333 + + HL I + + P+G + S D T ++W+ + +P Q Sbjct: 396 TGR---CIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLV 452 Query: 334 TAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSG 393 T + F +H N+ + DN ++ P + P K GH G+ ++ G Sbjct: 453 TG---VKFEPIH--GNFLLTGAYDNTAKIWT-HPGWS--PLKTLAGHEGKVMGLDISSDG 504 Query: 394 DGRYICSGDSKSRLF 408 CS D +L+ Sbjct: 505 QLIATCSYDRTFKLW 519 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 41/176 (23%), Positives = 75/176 (42%), Gaps = 24/176 (13%) Query: 155 IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRF 214 I + GH G + F + G L +GG D ++WD C+ +GH K I + F Sbjct: 358 ILHQEGHSMGVYDIAF-HQDGSLAGTGGLDAFGRVWDL-RTGRCIMFLEGHLKEIYGINF 415 Query: 215 TEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPA------DVESRPTNPHEFIVGLS 268 + + + S D + K+WD ++ R + + PA V+ P + + + G Sbjct: 416 SPNGYHIATGSGDNTCKVWD-----LRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGA- 469 Query: 269 NSKILHYDD--RVSENQGL--VQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 YD+ ++ + G ++T H ++ L DG + S D+T ++W Sbjct: 470 ------YDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519 >6G51-g nrPDB Length = 317 Score = 54.7 bits (130), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 60/267 (22%), Positives = 114/267 (42%), Gaps = 16/267 (5%) Query: 150 LPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPI 209 +P++ +R GH + + + G LSG D T+++WD R F GH K + Sbjct: 54 IPQRALR---GHSHFVSDV-VISSDGQFALSGSWDGTLRLWDLTTGTT-TRRFVGHTKDV 108 Query: 210 KALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNS---TPADVESRPTNPHEFIVG 266 ++ F+ D + +S S D+++K+W+T G K + S + V P + + IV Sbjct: 109 LSVAFSSDNRQIVSGSRDKTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVS 167 Query: 267 LSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINV 326 K++ + N L + H + + PDGS S +D +W+ +N Sbjct: 168 CGWDKLVKVWNL--ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD--LNE 223 Query: 327 PIKQISDTAQHSMPFLNVHPSQNYFCAQSMDN-RIYSFSLKPKYKRHPKKIFKGHSSAG- 384 + + L P++ + CA + + +I+ K +++ S A Sbjct: 224 GKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEP 283 Query: 385 -YGISLAFSGDGRYICSGDSKSRLFTW 410 SLA+S DG+ + +G + + + W Sbjct: 284 PQCTSLAWSADGQTLFAGYTDNLVRVW 310 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 45/176 (25%), Positives = 78/176 (44%), Gaps = 9/176 (5%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECL----RDFQGHNKPIKALRFT 215 GH T + P+ +ILS D TI +W D R +GH+ + + + Sbjct: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS 72 Query: 216 EDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHY 275 D Q LS S+D ++++WD TG TR + T + ++ + IV S K + Sbjct: 73 SDGQFALSGSWDGTLRLWDLTTG-TTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131 Query: 276 DDRVSENQGLVQTYDHHLSSILALKYFPDGSK--FISSSEDKTVRIWENQINVPIK 329 + + + VQ + H + +++ P+ S +S DK V++W N N +K Sbjct: 132 WNTLGVCKYTVQD-ESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW-NLANCKLK 185 Score = 33.1 bits (74), Expect = 0.25, Method: Compositional matrix adjust. Identities = 31/136 (22%), Positives = 60/136 (44%), Gaps = 17/136 (12%) Query: 283 QGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW-----ENQINVPIKQISDTAQH 337 +G ++ ++ ++ I FPD +S+S DKT+ +W E +P + + + H Sbjct: 8 RGTLKGHNGWVTQIATTPQFPD--MILSASRDKTIIMWKLTRDETNYGIPQRALRGHS-H 64 Query: 338 SMPFLNVHPSQNYFCAQSMDN--RIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDG 395 + + + + + S D R++ + +R F GH+ +S+AFS D Sbjct: 65 FVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRR-----FVGHTKDV--LSVAFSSDN 117 Query: 396 RYICSGDSKSRLFTWD 411 R I SG + W+ Sbjct: 118 RQIVSGSRDKTIKLWN 133 >4V6W-Ag nrPDB Length = 318 Score = 54.7 bits (130), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 55/247 (22%), Positives = 105/247 (42%), Gaps = 12/247 (4%) Query: 170 FLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRS 229 L G+ LSG D T+++WD + R F+GH K + ++ F+ D + +S S D++ Sbjct: 71 VLSSDGNYALSGSWDQTLRLWDLAAG-KTTRRFEGHTKDVLSVAFSADNRQIVSGSRDKT 129 Query: 230 VKIWDTETG---KVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLV 286 +K+W+T ++ H + V P + + IV + + + N L Sbjct: 130 IKLWNTLAECKFTIQEDGHTDWVSC-VRFSPNHSNPIIVSCGWDRTVKVWNLA--NCKLK 186 Query: 287 QTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHP 346 + H + + PDGS S +D +W+ +N + + L P Sbjct: 187 NNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWD--LNDGKNLYTLEHNDIINALCFSP 244 Query: 347 SQNYFC-AQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAG--YGISLAFSGDGRYICSGDS 403 ++ + C A +I+ + K + ++ S A +SLA+S DG+ + +G S Sbjct: 245 NRYWLCVAYGPSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTLFAGYS 304 Query: 404 KSRLFTW 410 + + W Sbjct: 305 DNTIRVW 311 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 41/177 (23%), Positives = 78/177 (44%), Gaps = 10/177 (5%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYEC-----LRDFQGHNKPIKALRF 214 GH T + PK I+S D T+ +W D + + GH+ I + Sbjct: 13 GHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDVVL 72 Query: 215 TEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILH 274 + D LS S+D+++++WD GK R ++ + + + + G S K + Sbjct: 73 SSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQIVSG-SRDKTIK 131 Query: 275 YDDRVSENQGLVQTYDHHLSSILALKYFPDGSK--FISSSEDKTVRIWENQINVPIK 329 + ++E + +Q D H + +++ P+ S +S D+TV++W N N +K Sbjct: 132 LWNTLAECKFTIQE-DGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVW-NLANCKLK 186 >5WYK-BB nrPDB Length = 943 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 37/139 (26%), Positives = 67/139 (48%), Gaps = 6/139 (4%) Query: 184 DHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKV-KT 242 D+T+K++ F + GH P+ ++ + D + ++SS D+++KIW + G K+ Sbjct: 552 DNTVKVF-FLDSMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKS 610 Query: 243 RLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYF 302 + +V+ P H F ++ + ++D E +Q H S + AL Sbjct: 611 LFAHQDSIMNVKFLP-QSHNFFSCSKDAVVKYWD---GEKFECIQKLYAHQSEVWALAVA 666 Query: 303 PDGSKFISSSEDKTVRIWE 321 DG +SSS D ++RIWE Sbjct: 667 TDGGFVVSSSHDHSIRIWE 685 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 24/75 (32%), Positives = 37/75 (49%), Gaps = 2/75 (2%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQ 219 H + +KFLP++ H S D +K WD +EC++ H + AL D Sbjct: 613 AHQDSIMNVKFLPQS-HNFFSCSKDAVVKYWD-GEKFECIQKLYAHQSEVWALAVATDGG 670 Query: 220 SFLSSSFDRSVKIWD 234 +SSS D S++IW+ Sbjct: 671 FVVSSSHDHSIRIWE 685 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 39/182 (21%), Positives = 77/182 (42%), Gaps = 24/182 (13%) Query: 201 DFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNP 260 + QG ++++ ++D L+++ + S+KIW+ +T K R + P Sbjct: 386 ELQGQRTDVRSIDISDD-NKLLATASNGSLKIWNIKTHKC-IRTFECGYALTCKFLPGGL 443 Query: 261 HEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 I+G N ++ +D ++ + L D H ++I +L DG + ++ S DKTV+ W Sbjct: 444 L-VILGTRNGELQLFD--LASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFW 500 Query: 321 ENQINVPIKQISDTAQHSMPFLNVH-----------------PSQNYFCAQSMDNRIYSF 363 + ++ + + T +P L +H P Y +DN + F Sbjct: 501 DFKVENSL--VPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISLLDNTVKVF 558 Query: 364 SL 365 L Sbjct: 559 FL 560 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 28/91 (30%), Positives = 42/91 (46%), Gaps = 9/91 (9%) Query: 150 LPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPI 209 + K V+ N+ GH T L+F TG ++SG D I +WD + L + H I Sbjct: 109 MSKTVLLNFNGHKAAITLLQF-DGTGTRLISGSKDSNIIVWDLVGEV-GLYKLRSHKDSI 166 Query: 210 KALRFTEDCQS---FLSSSFDRSVKIWDTET 237 CQ +S+S D +K+WD +T Sbjct: 167 TGFW----CQGEDWLISTSKDGMIKLWDLKT 193 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 37/150 (24%), Positives = 61/150 (40%), Gaps = 11/150 (7%) Query: 177 LILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDT- 235 L+ G D IK+WD L +F GH I L+F +S S D ++ +WD Sbjct: 93 LLAVGYADGVIKVWDLMSK-TVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLV 151 Query: 236 -ETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLS 294 E G K R H +S + ++++ S ++ D + ++T+ H Sbjct: 152 GEVGLYKLRSHKDS----ITGFWCQGEDWLISTSKDGMIKLWDL--KTHQCIETHIAHTG 205 Query: 295 SILALKYFPDGSKFISSSEDKTVRIWENQI 324 L D I++ D V+IW+ I Sbjct: 206 ECWGLAVKDD--LLITTGTDSQVKIWKLDI 233 Score = 38.1 bits (87), Expect = 0.007, Method: Compositional matrix adjust. Identities = 26/112 (23%), Positives = 52/112 (46%), Gaps = 15/112 (13%) Query: 222 LSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHE------------FIVGLSN 269 L +S V IWD +TG + ++L P ++R P E VG ++ Sbjct: 41 LITSALEDVNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLAVGYAD 100 Query: 270 SKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321 I +D ++ ++ ++ H ++I L++ G++ IS S+D + +W+ Sbjct: 101 GVIKVWD---LMSKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVWD 149 >5MWJ-A nrPDB Length = 337 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 43/168 (25%), Positives = 68/168 (40%), Gaps = 15/168 (8%) Query: 167 ALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSF 226 AL P + + S +D I +WD H+ +R FQGH + + D + Sbjct: 146 ALAISPDS-KVCFSCCSDGNIAVWDL-HNQTLVRQFQGHTDGASCIDISNDGTKLWTGGL 203 Query: 227 DRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGL--SNSKILHYDDRVSENQG 284 D +V+ WD G+ + S + PT VG+ SN ++LH + Sbjct: 204 DNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTG-EWLAVGMESSNVEVLHVNKP------ 256 Query: 285 LVQTYDHHL--SSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQ 330 Y HL S +L+LK+ G F+S+ +D + W I Q Sbjct: 257 --DKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQ 302 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 56/264 (21%), Positives = 103/264 (39%), Gaps = 27/264 (10%) Query: 157 NYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYH--------DYECLRDFQGHNKP 208 N H E A+ T H + +GG +K+WD H +CL + Sbjct: 46 NTLNHGEVVCAVTISNPTRH-VYTGGKG-CVKVWDISHPGNKSPVSQLDCLN----RDNY 99 Query: 209 IKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIV--G 266 I++ + D + + ++ IWD + + L S+ + +P + Sbjct: 100 IRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSC 159 Query: 267 LSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINV 326 S+ I +D NQ LV+ + H + DG+K + D TVR W+ + Sbjct: 160 CSDGNIAVWD---LHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGR 216 Query: 327 PIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYG 386 ++Q T+Q + L P+ + A M+ S +++ + P K ++ H Sbjct: 217 QLQQHDFTSQ--IFSLGYCPTGEWL-AVGME----SSNVEVLHVNKPDK-YQLHLHESCV 268 Query: 387 ISLAFSGDGRYICSGDSKSRLFTW 410 +SL F+ G++ S + L W Sbjct: 269 LSLKFAYCGKWFVSTGKDNLLNAW 292 >5FL8-q nrPDB Length = 515 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 42/174 (24%), Positives = 76/174 (43%), Gaps = 19/174 (10%) Query: 152 KKVIRNYPGHPEGTTALKFLPKTGH---LILSGGNDHTIKIWDFYHDYECLRDFQGHNKP 208 KK + NY K K G+ ++++ +D+T+ +W+ + + GH K Sbjct: 354 KKALENYE---------KICKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKL 404 Query: 209 IKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKT--RLHLNSTPADVESRPTNPHEFIVG 266 + + F+ D + +S+SFD S+K+WD GK + R H+ S + ++ +V Sbjct: 405 VNHVAFSPDGRYIVSASFDNSIKLWDGRDGKFISTFRGHVASV---YQVAWSSDCRLLVS 461 Query: 267 LSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 S L D + L H + + + DG + S +DK VR+W Sbjct: 462 CSKDTTLKVWD--VRTRKLSVDLPGHKDEVYTVDWSVDGKRVCSGGKDKMVRLW 513 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 68/300 (22%), Positives = 117/300 (39%), Gaps = 74/300 (24%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQ 219 GH + +K+ + L+ SG +D T+++WD C+ + H + L + D Sbjct: 276 GHTNSVSCVKWGGQ--GLLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSLSTD-Y 332 Query: 220 SFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRV 279 + +FD TGK +P+ P E + K L +++ Sbjct: 333 ALRIGAFD--------HTGK----------------KPSTPEE-----AQKKALENYEKI 363 Query: 280 SENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTA---- 335 + G + +++S+D T+ +W P+K A Sbjct: 364 CKKNGNSEEM------------------MVTASDDYTMFLWN-----PLKSTKPIARMTG 400 Query: 336 -QHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKI--FKGHSSAGYGISLAFS 392 Q + + P Y + S DN S+K R K I F+GH ++ Y + A+S Sbjct: 401 HQKLVNHVAFSPDGRYIVSASFDN-----SIKLWDGRDGKFISTFRGHVASVYQV--AWS 453 Query: 393 GDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNK-PITQVDWHPQETSKVICSGAAGKI 451 D R + S + L WD T +L ++ +PG+K + VDW K +CSG K+ Sbjct: 454 SDCRLLVSCSKDTTLKVWDVRTRKL--SVDLPGHKDEVYTVDW--SVDGKRVCSGGKDKM 509 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 47/200 (23%), Positives = 86/200 (43%), Gaps = 27/200 (13%) Query: 141 EERISFRCYLPKKVIRNYP---------GHPEGTTALKFLPKTGHLILSGGNDHTIKIWD 191 E++I+ Y P+ V + P GH F P T +++G D+T +IWD Sbjct: 114 EDQITL-LYTPRAVFKVKPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWD 172 Query: 192 FYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKV---KTRLH--- 245 + +GH + + ++ D + + S D ++++WD ++G+ R H Sbjct: 173 CDTQTP-MHTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKW 231 Query: 246 ---LNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQ-TYDHHLSSILALKY 301 L+ P + + P + S + D VS + Q T H +S+ +K+ Sbjct: 232 ITSLSWEPIHLVKPGSKPR--LASSSKDGTIKIWDTVSR---VCQYTMSGHTNSVSCVKW 286 Query: 302 FPDGSKFISSSEDKTVRIWE 321 G + S S D+TVR+W+ Sbjct: 287 GGQGLLY-SGSHDRTVRVWD 305 Score = 31.2 bits (69), Expect = 0.89, Method: Compositional matrix adjust. Identities = 23/91 (25%), Positives = 38/91 (41%), Gaps = 4/91 (4%) Query: 292 HLSSILALKYFP-DGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNY 350 H S+IL + P S+ ++ + D T RIW+ P+ + + ++ P Sbjct: 142 HGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVL-CVSWSPDGEV 200 Query: 351 FCAQSMDNRIYSFSLKPKYKRHPKKIFKGHS 381 SMDN I + PK + +GHS Sbjct: 201 IATGSMDNTIRLWD--PKSGQCLGDALRGHS 229 Score = 29.6 bits (65), Expect = 3.0, Method: Compositional matrix adjust. Identities = 17/64 (26%), Positives = 31/64 (48%), Gaps = 2/64 (3%) Query: 373 PKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQV 432 P KGH + + + +++S DG I +G + + WD + + L + +K IT + Sbjct: 178 PMHTLKGHYN--WVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSL 235 Query: 433 DWHP 436 W P Sbjct: 236 SWEP 239 >5L9T-R nrPDB Length = 493 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 44/175 (25%), Positives = 80/175 (45%), Gaps = 11/175 (6%) Query: 151 PKKVIRNYPGHPEGTTALKFLPKTGH-LILSGGNDHTIKIWDFYHDYECLRDFQGHNKPI 209 P + R GH + LK+ T H L+ SGGND+ + +W+ + ++ + H + Sbjct: 302 PLQSERRLQGHRQEVCGLKW--STDHQLLASGGNDNKLLVWN-HSSLSPVQQYTEHLAAV 358 Query: 210 KALRFTEDCQSFLSS---SFDRSVKIWDTETGKVKTRLHLNSTPADVE-SRPTNPHEFIV 265 KA+ ++ L+S + DR ++ W+T TG+ + S ++ S+ N Sbjct: 359 KAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTH 418 Query: 266 GLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 G S ++IL + + V H +L L PDG ++ + D+T+R W Sbjct: 419 GYSQNQILVWK---YPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFW 470 Score = 32.0 bits (71), Expect = 0.63, Method: Compositional matrix adjust. Identities = 25/104 (24%), Positives = 42/104 (40%), Gaps = 3/104 (2%) Query: 230 VKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTY 289 V+IWD GK + L ++ A V + N + G + IL D R Q + Sbjct: 253 VQIWDAAAGKKLSMLEGHT--ARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQS-ERRL 309 Query: 290 DHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISD 333 H + LK+ D S D + +W + P++Q ++ Sbjct: 310 QGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTE 353 >5MZH-A nrPDB Length = 452 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 40/162 (24%), Positives = 64/162 (39%), Gaps = 4/162 (2%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQ 219 GH A+ F G I++G D T K+WD Y + +GH I L F Sbjct: 134 GHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTG-QLYYTLKGHQTEIVCLSFNPQST 192 Query: 220 SFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRV 279 + S D + K+WD ETG+ + L + T + G + +D R Sbjct: 193 IIATGSMDNTAKLWDVETGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRT 252 Query: 280 SENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321 + V H + + ++ G+ +S S D T R+W+ Sbjct: 253 GQ---CVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWD 291 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 39/149 (26%), Positives = 63/149 (42%), Gaps = 8/149 (5%) Query: 175 GHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWD 234 G L++SG D T ++WD CL QGH + + F +S+S D S +++ Sbjct: 275 GTLVVSGSIDCTSRLWDV-RSGRCLSVKQGHTDEVLDVAFDAAGTKMVSASADGSARLYH 333 Query: 235 TETGKVKTRLHLNSTPADVESRPTNPH--EFIVGLSNSKILHYDDRVSENQGLVQTYDHH 292 T TG + L ++ NP I S+ +D E +Q + H Sbjct: 334 TLTGVCQHTL--VGHEGEISKVAFNPQGTRLITASSDKTCRLWDCDTGE---CLQVLEGH 388 Query: 293 LSSILALKYFPDGSKFISSSEDKTVRIWE 321 I + + +G I+ S+D T RIW+ Sbjct: 389 TDEIFSCAFNYEGDFIITGSKDNTCRIWK 417 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 48/202 (23%), Positives = 89/202 (44%), Gaps = 18/202 (8%) Query: 135 VDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYH 194 +D L ++ SF + KV+R H T F K+G ++G D T K+W+ + Sbjct: 73 IDKMLEQQHHSFTLF---KVLR---AHILPLTNCAF-NKSGDRFITGSYDRTCKVWNTFT 125 Query: 195 DYECLRDFQGHNKPIKALRFTED-CQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADV 253 E +GH + A+ F ++ SFD++ K+WD TG++ L + T ++ Sbjct: 126 GEEVF-TLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQT--EI 182 Query: 254 ESRPTNPHEFIVG---LSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFIS 310 NP I+ + N+ L +D + + T H + I++L + G ++ Sbjct: 183 VCLSFNPQSTIIATGSMDNTAKL-WDVETGQERA---TLAGHRAEIVSLGFNTGGDLIVT 238 Query: 311 SSEDKTVRIWENQINVPIKQIS 332 S D R+W+ + + +S Sbjct: 239 GSFDHDSRLWDVRTGQCVHVLS 260 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 52/233 (22%), Positives = 94/233 (40%), Gaps = 20/233 (8%) Query: 193 YHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRL--HLNSTP 250 +H + + + H P+ F + F++ S+DR+ K+W+T TG+ L H N Sbjct: 81 HHSFTLFKVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVY 140 Query: 251 ADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFIS 310 A + P + + G + +D + L T H + I+ L + P + + Sbjct: 141 AIAFNNPYGD-KIVTGSFDKTCKLWDAYTGQ---LYYTLKGHQTEIVCLSFNPQSTIIAT 196 Query: 311 SSEDKTVRIWENQINVPIKQISDTAQHSMPF--LNVHPSQNYFCAQSMDNRIYSFSLKPK 368 S D T ++W+ + ++ + A H L + + S D+ + ++ Sbjct: 197 GSMDNTAKLWDVETG---QERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTG 253 Query: 369 YKRHPKKIFKGHSSAGYGISLAFSGDGRYICSG--DSKSRLFTWDWNTSRLLN 419 H + GH G S F+ G + SG D SRL WD + R L+ Sbjct: 254 QCVH---VLSGHR--GEVSSTQFNYAGTLVVSGSIDCTSRL--WDVRSGRCLS 299 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 21/79 (26%), Positives = 38/79 (48%), Gaps = 2/79 (2%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQ 219 GH + + F P+ G +++ +D T ++WD ECL+ +GH I + F + Sbjct: 345 GHEGEISKVAFNPQ-GTRLITASSDKTCRLWD-CDTGECLQVLEGHTDEIFSCAFNYEGD 402 Query: 220 SFLSSSFDRSVKIWDTETG 238 ++ S D + +IW T Sbjct: 403 FIITGSKDNTCRIWKALTA 421 >3JAP-g nrPDB Length = 326 Score = 51.6 bits (122), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 64/313 (20%), Positives = 130/313 (41%), Gaps = 70/313 (22%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYEC----LRDFQGHNKPIKALRFT 215 GH T+L +L++SG D T+ W + + +R ++GH+ ++ + + Sbjct: 16 GHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDVVVS 75 Query: 216 EDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEF-IVGLSNSKILH 274 D +S+S+D+++++W+ TG + R ++ DV S + + I+ S K + Sbjct: 76 ADGNYAVSASWDKTLRLWNLATGNSEARFVGHT--GDVLSVAIDANSSKIISASRDKTIR 133 Query: 275 YDDRVSENQGLVQTYDHHLSSI-LALKYFPDGS------KFISSSEDKTVRIWE------ 321 + V + ++ + ++ + +A K DG F+S+ DK VR W Sbjct: 134 VWNTVGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWSLNEDSY 193 Query: 322 ----------NQINV----PIKQISDTA-----------QHSMPFLN-----------VH 345 N INV P ++ +A +H F+N Sbjct: 194 RIEADFIGHNNYINVVQPSPDGSLAASAGKDGQIYVWNLKHKSAFMNFDAKDEVFALAFS 253 Query: 346 PSQNYFCAQS--------MDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRY 397 PS+ + A + ++N + LKP++ + K + + +SLA+S DG+ Sbjct: 254 PSRFWLTAATASGIKIYDLENEVLIDELKPEFAGYTK------AQDPHAVSLAWSADGQT 307 Query: 398 ICSGDSKSRLFTW 410 + +G + + + W Sbjct: 308 LFAGYTDNVIRVW 320 >4BTS-AR nrPDB Length = 343 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 52/255 (20%), Positives = 99/255 (38%), Gaps = 74/255 (29%) Query: 177 LILSGGNDHTIKIWDFYHDYECL------RDFQGHNKPIKALRFTEDCQSFLSSSFDRSV 230 +++SG D T+ IW Y + + + GHN + L +++ +SSS+D+++ Sbjct: 41 VLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHNHFVSDLALSQENCFAISSSWDKTL 100 Query: 231 KIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYD 290 ++WD TG R VG Sbjct: 101 RLWDLRTGTTYKRF--------------------VG------------------------ 116 Query: 291 HHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHS--------MPFL 342 H S + ++ + PD + +S+ ++ +++W N + ++ HS P + Sbjct: 117 -HQSEVYSVAFSPDNRQILSAGAEREIKLW-NILGECKFSSAEKENHSDWVSCVRYSPIM 174 Query: 343 ----NVHPSQNYFCAQSMDNR--IYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGR 396 V P YF + D R +++ + + +Y FK H S +S+ S +G+ Sbjct: 175 KSANKVQPFAPYFASVGWDGRLKVWNTNFQIRYT------FKAHESNVNHLSI--SPNGK 226 Query: 397 YICSGDSKSRLFTWD 411 YI +G +L WD Sbjct: 227 YIATGGKDKKLLIWD 241 Score = 38.1 bits (87), Expect = 0.007, Method: Compositional matrix adjust. Identities = 41/141 (29%), Positives = 63/141 (44%), Gaps = 20/141 (14%) Query: 283 QGLVQTYDHHLSSILA---LKYFPDGSKFISSSEDKTVRIW----ENQ---INVPIKQIS 332 +G+++ + ++SI+A K D IS S DKTV IW E Q +P K ++ Sbjct: 14 RGILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALT 73 Query: 333 DTAQHSMPFLNVHPSQNYFCAQSMDN--RIYSFSLKPKYKRHPKKIFKGHSSAGYGISLA 390 H + L + + + S D R++ YKR F GH S Y S+A Sbjct: 74 G-HNHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKR-----FVGHQSEVY--SVA 125 Query: 391 FSGDGRYICSGDSKSRLFTWD 411 FS D R I S ++ + W+ Sbjct: 126 FSPDNRQILSAGAEREIKLWN 146 >5FVM-C nrPDB Length = 303 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 57/289 (19%), Positives = 113/289 (39%), Gaps = 78/289 (26%) Query: 177 LILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTE 236 ++ S G DHTI+ W+ C R Q + + L T D + +L+++ Sbjct: 4 ILASAGYDHTIRFWEALTGV-CSRTIQHADSQVNRLEITSD-KKYLAAA----------- 50 Query: 237 TGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSI 296 G + RL+ D+ S NP V +++ H ++ Sbjct: 51 -GHLHVRLY------DIRSNNPNP-------------------------VSSFEGHKGNV 78 Query: 297 LALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPF--LNVHPSQNYF--C 352 ++ + + +SSSED T+++W+ V + +H+ P + +HP+Q C Sbjct: 79 TSIAFQQENRWMVSSSEDGTIKVWD----VRSPSVQRNYKHNAPVNEVAIHPNQGELISC 134 Query: 353 AQSMDNRIYSFS-------LKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKS 405 Q + RI+ L P+ P + SL+ + DG + +G++K Sbjct: 135 DQDGNIRIWDLGENQCTNQLTPE-DNTPLQ------------SLSVASDGSMLVAGNNKG 181 Query: 406 RLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVC 454 + W R+ ++ +P+T+ H + ++V+ S + C Sbjct: 182 NCYVW-----RMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATC 225 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 55/262 (20%), Positives = 110/262 (41%), Gaps = 21/262 (8%) Query: 163 EGTTALKFLPKTGHLILSGGNDHTIKIWDFY-HDYECLRDFQGHNKPIKALRFTEDCQSF 221 E T+ K+L GHL ++++D ++ + F+GH + ++ F ++ + Sbjct: 39 EITSDKKYLAAAGHL--------HVRLYDIRSNNPNPVSSFEGHKGNVTSIAFQQENRWM 90 Query: 222 LSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSE 281 +SSS D ++K+WD + V+ N+ +V P N E I + I +D + E Sbjct: 91 VSSSEDGTIKVWDVRSPSVQRNYKHNAPVNEVAIHP-NQGELISCDQDGNIRIWD--LGE 147 Query: 282 NQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINV---PIKQISDTAQHS 338 NQ Q + + +L DGS ++ + +W + ++ ++ H+ Sbjct: 148 NQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHT 207 Query: 339 MPFLNVHPSQNY--FCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGR 396 V S + S D+ ++++ Y+ + GH + AFS D Sbjct: 208 KYITRVLLSADVKNLATCSADHTARVWNIEDNYQL--ETTLDGHQR--WVWDCAFSADSA 263 Query: 397 YICSGDSKSRLFTWDWNTSRLL 418 Y+ + S + WD +TS ++ Sbjct: 264 YLVTACSDHYVRLWDLSTSEIV 285 Score = 34.7 bits (78), Expect = 0.094, Method: Compositional matrix adjust. Identities = 43/194 (22%), Positives = 74/194 (38%), Gaps = 32/194 (16%) Query: 154 VIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGH-NKPIKAL 212 V RNY H + P G LI S D I+IWD + +C N P+++L Sbjct: 109 VQRNYK-HNAPVNEVAIHPNQGELI-SCDQDGNIRIWDLGEN-QCTNQLTPEDNTPLQSL 165 Query: 213 RFTEDCQSFLSSSFDRSVKIW------DTET----------GKVKTRLHLNSTPADVESR 256 D ++ + + +W D T K TR+ L+ ADV++ Sbjct: 166 SVASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLS---ADVKNL 222 Query: 257 PTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKT 316 T + + N + +N L T D H + + D + +++ D Sbjct: 223 ATCSADHTARVWN---------IEDNYQLETTLDGHQRWVWDCAFSADSAYLVTACSDHY 273 Query: 317 VRIWENQINVPIKQ 330 VR+W+ + ++Q Sbjct: 274 VRLWDLSTSEIVRQ 287 >6BX3-A nrPDB Length = 314 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 37/153 (24%), Positives = 63/153 (41%), Gaps = 8/153 (5%) Query: 175 GHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWD 234 G I + +D +++I + Y L F GH P+ +L F +SS D S+KIWD Sbjct: 66 GQCIATASDDFSVEI--IHLSYGLLHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWD 123 Query: 235 TETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYD---- 290 T G + + +S P N + S ++ D + + TYD Sbjct: 124 TLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWK 183 Query: 291 --HHLSSILALKYFPDGSKFISSSEDKTVRIWE 321 + + I +K+ + + S D V+IW+ Sbjct: 184 RENGVVPISQVKFSENARYLLVKSLDGVVKIWD 216 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 49/227 (21%), Positives = 94/227 (41%), Gaps = 21/227 (9%) Query: 149 YLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKP 208 +L ++ + GH +L F + G+L+ + D +IKIWD + ++ H++ Sbjct: 82 HLSYGLLHTFIGHTAPVISLTF-NRKGNLLFTSSMDESIKIWDTLNG-SLMKTISAHSEA 139 Query: 209 IKALRFTEDCQSFLSS-SFDRSVKIWDTETGKVKTRLHLNS--------TPADVESRPTN 259 + ++ + S LSS S+D ++I+D ETG L + P N Sbjct: 140 VVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSEN 199 Query: 260 PHEFIVGLSNSKILHYDD------RVSENQGLVQTYDHHLSSILALKYFPDGSK--FISS 311 +V + + +D R + Q L + HH + L DGS IS Sbjct: 200 ARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNP-EDGSTPLVISG 258 Query: 312 SEDKTVRIWENQINVPIKQISDTA-QHSMPFLNVHPSQNYFCAQSMD 357 E+ + W + ++ + + HS P +++H N C+ +++ Sbjct: 259 YENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALN 305 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 47/203 (23%), Positives = 80/203 (39%), Gaps = 28/203 (13%) Query: 141 EERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLR 200 +E I L +++ H E ++ ++ SG D I+I+D CL+ Sbjct: 116 DESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFD-AETGHCLK 174 Query: 201 ------DFQGHNK--PIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPAD 252 D++ N PI ++F+E+ + L S D VKIWD G V + Sbjct: 175 TLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKG 234 Query: 253 VESRPT-----NPHE-----FIVGLSNSKILHYDDRVSENQGLVQTYD----HHLSSILA 298 V NP + I G N I ++ S+ + L+Q D HH S +++ Sbjct: 235 VLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWN---SDTKSLLQLLDGSLYHHSSPVMS 291 Query: 299 LKYFPDGSKFISSSEDKTVRIWE 321 + F G+ S + + +W Sbjct: 292 IHCF--GNIMCSLALNGDCCLWR 312 >5OQL-J nrPDB Length = 912 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 31/107 (28%), Positives = 47/107 (43%), Gaps = 23/107 (21%) Query: 160 GHPEGTTALKFLPKTGHLI-------------LSGGNDHTIKIWDFYHDYECLRDFQGHN 206 GH G ++F P +I L+G D TIK+W+ DY C+R F+GH+ Sbjct: 584 GHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKLWNL-SDYTCIRTFEGHS 642 Query: 207 KPIKAL---------RFTEDCQSFLSSSFDRSVKIWDTETGKVKTRL 244 + + T+ F S+ D VK+WD TG+ + L Sbjct: 643 HNVLKVVWLHISRDDSITKTKVQFASAGADTLVKVWDANTGETECTL 689 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 39/156 (25%), Positives = 63/156 (40%), Gaps = 35/156 (22%) Query: 174 TGHLILSGGNDHTIKIWDF---YHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSV 230 +GH I SG D+T ++W + Y C F GH + + A+ + S +F Sbjct: 444 SGHWIASGSKDNTARLWRVDPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAF---- 499 Query: 231 KIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDD--RVSENQGLVQT 288 P D +P F++ S + + D R + G + + Sbjct: 500 -----------------KNPLD------HPPAFLISGSQDRFVQKRDIPRQLQKGGKLTS 536 Query: 289 YDHHLS---SILALKYFPDGSKFISSSEDKTVRIWE 321 L+ I AL P+G F S+S+DKTV+IW+ Sbjct: 537 SLRRLAHDKDINALDISPNGKLFASASQDKTVKIWD 572 Score = 34.7 bits (78), Expect = 0.084, Method: Compositional matrix adjust. Identities = 41/161 (25%), Positives = 65/161 (40%), Gaps = 40/161 (24%) Query: 107 IEVEEVSHFYGKSEKDYQGRGY-LYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPE-- 163 ++V+ H+ KD R + + P N+ S+ CY + GH E Sbjct: 439 LDVDWSGHWIASGSKDNTARLWRVDPANN----------SYTCYAV------FTGHLESV 482 Query: 164 GTTAL-KFLPKTG------------HLILSGGNDHTIKIWDFYHDYE-------CLRDFQ 203 G AL K +P ++SG D ++ D + LR Sbjct: 483 GAVALPKVVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRL- 541 Query: 204 GHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRL 244 H+K I AL + + + F S+S D++VKIWD E +V+ L Sbjct: 542 AHDKDINALDISPNGKLFASASQDKTVKIWDVEKLEVQGIL 582 Score = 33.9 bits (76), Expect = 0.15, Method: Compositional matrix adjust. Identities = 57/278 (20%), Positives = 96/278 (34%), Gaps = 62/278 (22%) Query: 181 GGNDHTIKIWDFYHDYEC------LRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWD 234 G D I+I+D Y R + H ++ + ++ + + LS S D+++ +W Sbjct: 201 GTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLWL 260 Query: 235 TETGKVKTRLHLNSTPADVESRPTNPHEFI--VGLSNSKILHYDDRVSENQGLVQTYDHH 292 G + P HE + VG N Y S + T HH Sbjct: 261 WRDGIW-------------QGTPMLRHELLESVGFLNEGKWMYSAGTSGVLRIWDTTTHH 307 Query: 293 L-----------SSILALKYFPDGSKFISSSEDKTVRIW------------ENQINVPIK 329 +IL+ P+ S + + D T+ ++ E + P + Sbjct: 308 EITKKQDAKSEGEAILSAVSLPERSLILCAQADFTLVLYRVPSPADVVSSSEGILLEPFR 367 Query: 330 QISDTAQHSMPFLNVHPSQNYFC--AQSMDNRIYSFSLKPKYKR------------HPKK 375 +IS T + + P Q+ S D RI S Y H Sbjct: 368 RISGTHDEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVA 427 Query: 376 IFKGHSSAGYGISLAFSGDGRYICSG--DSKSRLFTWD 411 + KGH + + +S G +I SG D+ +RL+ D Sbjct: 428 LLKGHEDIVMSLDVDWS--GHWIASGSKDNTARLWRVD 463 >6Q8F-A nrPDB Length = 514 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 44/197 (22%), Positives = 88/197 (44%), Gaps = 13/197 (6%) Query: 177 LILSGGNDHTIKIWDFYHDYECLRDFQ-GHNKPIKALRFTEDCQSFLSSSFDRSVKIWDT 235 ++ +G D IK+W +CLR F+ H+K + L F++D LS+SFD++++I Sbjct: 279 MLATGAQDGKIKVWKI-QSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGL 337 Query: 236 ETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSE------NQGLVQTY 289 ++GK +S+ + + + H I S+ + ++ + +E + G Sbjct: 338 KSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGT 397 Query: 290 DHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFL--NVHPS 347 D ++S++ L P+ F+ + TV I Q + ++ S + F+ + P Sbjct: 398 DITVNSVILLPKNPE--HFVVCNRSNTVVIMNMQGQI-VRSFSSGKREGGDFVCCALSPR 454 Query: 348 QNYFCAQSMDNRIYSFS 364 + D +Y FS Sbjct: 455 GEWIYCVGEDFVLYCFS 471 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 44/229 (19%), Positives = 83/229 (36%), Gaps = 42/229 (18%) Query: 204 GHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEF 263 G ++ RF+ D Q ++ S D +++W+ TGK++ L + Sbjct: 213 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQA--------------- 257 Query: 264 IVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQ 323 + DD ++L + + D + ++D +++W+ Q Sbjct: 258 -----QDNFMMMDD-----------------AVLCMCFSRDTEMLATGAQDGKIKVWKIQ 295 Query: 324 INVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSA 383 +++ + L+ + + S D I LK K F+GHSS Sbjct: 296 SGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSG---KTLKEFRGHSS- 351 Query: 384 GYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQV 432 + F+ DG YI S S + W+ T+ N K G+ T + Sbjct: 352 -FVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDI 399 Score = 31.6 bits (70), Expect = 0.72, Method: Compositional matrix adjust. Identities = 35/177 (19%), Positives = 75/177 (42%), Gaps = 12/177 (6%) Query: 153 KVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQ------GHN 206 K ++ + GH F + GH I+S +D T+KIW+ EC F+ G + Sbjct: 341 KTLKEFRGHSSFVNEATF-TQDGHYIISASSDGTVKIWNM-KTTECSNTFKSLGSTAGTD 398 Query: 207 KPIKA-LRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPH-EFI 264 + + + ++ + F+ + +V I + + V++ D +P E+I Sbjct: 399 ITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWI 458 Query: 265 VGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321 + +L+ V+ L +T H ++ + + P + + SED +++W+ Sbjct: 459 YCVGEDFVLYCFSTVTGK--LERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWK 513 >1NR0-A nrPDB Length = 611 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 64/308 (20%), Positives = 125/308 (40%), Gaps = 65/308 (21%) Query: 157 NYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTE 216 N G ++ F P I+SG +D+T+ I++ ++ F H K + ++R+ Sbjct: 142 NLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFE-GPPFKFKSTFGEHTKFVHSVRYNP 200 Query: 217 DCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYD 276 D F S+ D ++ +++ G+ +K ++ Sbjct: 201 DGSLFASTGGDGTIVLYN-------------------------------GVDGTKTGVFE 229 Query: 277 DRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQ 336 D +N H S+ L + PDG+K S+S DKT++IW NV ++ T Sbjct: 230 DDSLKNVA-------HSGSVFGLTWSPDGTKIASASADKTIKIW----NVATLKVEKTIP 278 Query: 337 HSMPF----LNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFS 392 L + ++ + S + I +F + P+ ++ GH+ A +L+ S Sbjct: 279 VGTRIEDQQLGIIWTKQALVSISANGFI-NF-VNPELGS-IDQVRYGHNKA--ITALSSS 333 Query: 393 GDGRYICSGDSKSRLFTWDWNT-----------SRLLNNIKIPGNKPITQVDWHPQETSK 441 DG+ + S D++ + +WD +T + ++ IK + V W + K Sbjct: 334 ADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSW--DDHLK 391 Query: 442 VICSGAAG 449 V+ +G +G Sbjct: 392 VVPAGGSG 399 Score = 37.7 bits (86), Expect = 0.012, Method: Compositional matrix adjust. Identities = 38/179 (21%), Positives = 79/179 (44%), Gaps = 13/179 (7%) Query: 151 PKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWD--------FYHDYECLRDF 202 P K + H + ++++ P G L S G D TI +++ + D + L++ Sbjct: 179 PFKFKSTFGEHTKFVHSVRYNPD-GSLFASTGGDGTIVLYNGVDGTKTGVFED-DSLKNV 236 Query: 203 QGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHE 262 H+ + L ++ D S+S D+++KIW+ T KV+ + + + D + + Sbjct: 237 -AHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQ 295 Query: 263 FIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321 +V +S + +++ + E + Q H +I AL DG S+ + + W+ Sbjct: 296 ALVSISANGFINFVN--PELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWD 352 Score = 30.0 bits (66), Expect = 2.4, Method: Compositional matrix adjust. Identities = 25/94 (26%), Positives = 44/94 (46%), Gaps = 10/94 (10%) Query: 231 KIWDTETGKVKTRLHLNSTPADVESRP-TNPHEFIVGLSNS-KILHYDDRVSENQGLVQT 288 K+ +VKT +H PA++ S +N F+V S K++ Y V+ N L T Sbjct: 476 KLSGASVSEVKTIVH----PAEITSVAFSNNGAFLVATDQSRKVIPYS--VANNFELAHT 529 Query: 289 --YDHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 + H + + + + PD + + S D +V +W Sbjct: 530 NSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVW 563 >6GMH-W nrPDB Length = 305 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 40/151 (26%), Positives = 74/151 (49%), Gaps = 6/151 (3%) Query: 175 GHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWD 234 G + SG D I I+D + L +GH PI++L F+ D Q +++S D +KI+D Sbjct: 160 GKYLASGAIDGIINIFDIATG-KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYD 218 Query: 235 TETGKVKTRLHLNST-PADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHL 293 + + L +++ +V P + H F+ S+ + +D + V T+ H Sbjct: 219 VQHANLAGTLSGHASWVLNVAFCPDDTH-FVSSSSDKSVKVWD---VGTRTCVHTFFDHQ 274 Query: 294 SSILALKYFPDGSKFISSSEDKTVRIWENQI 324 + +KY +GSK +S +D+ + I++ I Sbjct: 275 DQVWGVKYNGNGSKIVSVGDDQEIHIYDCPI 305 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 52/243 (21%), Positives = 99/243 (40%), Gaps = 20/243 (8%) Query: 178 ILSGGNDHTIKIWDFYHDYECLR-DFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTE 236 +++G D +K+W + + L+ +GH + ++ + SSS D +++WD E Sbjct: 35 VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94 Query: 237 TGK-VKTRLHLNSTPADVESRPTNP--HEFIVGLSNSKILHYDDRVSENQGLVQTYDHHL 293 GK +K+ +++ P D + +P G K+ + + + + D Sbjct: 95 NGKQIKS---IDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKE---YSLDTRG 148 Query: 294 SSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPF--LNVHPSQNYF 351 IL++ Y PDG S + D + I++ K + H+MP L P Sbjct: 149 KFILSIAYSPDGKYLASGAIDGIINIFDIATG---KLLHTLEGHAMPIRSLTFSPDSQLL 205 Query: 352 CAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWD 411 S D I + ++ + GH+S + +++AF D + S S + WD Sbjct: 206 VTASDDGYIKIYDVQ---HANLAGTLSGHAS--WVLNVAFCPDDTHFVSSSSDKSVKVWD 260 Query: 412 WNT 414 T Sbjct: 261 VGT 263 Score = 36.6 bits (83), Expect = 0.022, Method: Compositional matrix adjust. Identities = 28/113 (24%), Positives = 51/113 (45%), Gaps = 6/113 (5%) Query: 310 SSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKY 369 SSS D +R+W+ + IK I D L P Y + ++ F ++ Sbjct: 81 SSSLDAHIRLWDLENGKQIKSI-DAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESG- 138 Query: 370 KRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIK 422 KK + + + +S+A+S DG+Y+ SG + +D T +LL+ ++ Sbjct: 139 ----KKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLE 187 >5GAN-H nrPDB Length = 465 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 48/178 (26%), Positives = 78/178 (43%), Gaps = 13/178 (7%) Query: 283 QGLVQTYDHHLSSILALKYFPDGS-KFISSSEDKTVRIWE-NQINVPIKQISDTAQHSMP 340 Q L Q D H+ I A+ + PD + + IS +ED ++ ++ + ++ + D H Sbjct: 208 QPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERR 267 Query: 341 FLNV--HPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYI 398 +V HPS + + S D ++ L + +GH + SL+F DG + Sbjct: 268 ISDVKYHPSGKFIGSASHD---MTWRLWDASTHQELLLQEGHDKGVF--SLSFQCDGSLV 322 Query: 399 CSGDSKSRLFTWDWNTSRLLNNIKIPG-NKPITQVDWHPQETSKVICSGAAGKIYVCD 455 CSG S WD + + + + G +KPI V W P +V G G I V D Sbjct: 323 CSGGMDSLSMLWDIRSGSKV--MTLAGHSKPIYTVAWSPN-GYQVATGGGDGIINVWD 377 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 38/170 (22%), Positives = 74/170 (43%), Gaps = 5/170 (2%) Query: 153 KVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKAL 212 +++ + GH + +K+ P +G I S +D T ++WD E L +GH+K + +L Sbjct: 256 RLLGDLVGHERRISDVKYHP-SGKFIGSASHDMTWRLWDASTHQELLLQ-EGHDKGVFSL 313 Query: 213 RFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKI 272 F D S D +WD +G L +S P + N ++ G + I Sbjct: 314 SFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGII 373 Query: 273 LHYDDRVSENQGLVQTYDHHLSSILALKYFPD--GSKFISSSEDKTVRIW 320 +D R ++G + H + + +++ + G K +S D + ++ Sbjct: 374 NVWDIR-KRDEGQLNQILAHRNIVTQVRFSKEDGGKKLVSCGYDNLINVY 422 Score = 28.5 bits (62), Expect = 6.0, Method: Compositional matrix adjust. Identities = 15/60 (25%), Positives = 30/60 (50%), Gaps = 1/60 (1%) Query: 175 GHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWD 234 G ++S G D+ I ++ + + GH I +L + + +S +DRS+K+W+ Sbjct: 407 GKKLVSCGYDNLINVYS-SDTWLKMGSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465 >5WJC-A nrPDB Length = 430 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 32/123 (26%), Positives = 55/123 (44%), Gaps = 11/123 (8%) Query: 133 NDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF 192 +D + + + R++ PK + H + A+ P +L+ + D T+ +WD Sbjct: 256 DDCTLQIHDTRLNPEEEAPKVI----QAHSKAINAVAINPFNDYLLATASADKTVALWDL 311 Query: 193 YHDYECLRDFQGHNKPIKALRFTEDCQSFL-SSSFDRSVKIWDTETGKVKTRLHLNSTPA 251 + Y+ L +GH + L ++ + L SSS DR V IWD E ++ TP Sbjct: 312 RNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLE------KIGEEQTPE 365 Query: 252 DVE 254 D E Sbjct: 366 DAE 368 Score = 31.6 bits (70), Expect = 0.82, Method: Compositional matrix adjust. Identities = 13/45 (28%), Positives = 25/45 (55%), Gaps = 8/45 (17%) Query: 373 PKKIFKGHSSAGYGI--------SLAFSGDGRYICSGDSKSRLFT 409 P+ + KGH++ G+G+ +LA + + IC D +++ FT Sbjct: 174 PQAVLKGHTAEGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFT 218 >5WBU-D nrPDB Length = 328 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 60/259 (23%), Positives = 104/259 (40%), Gaps = 23/259 (8%) Query: 167 ALKFLPKTGHLILSGGNDHTIKIWDF-YHDYECLRDFQGHNKPIKALRFTEDCQSFLSSS 225 AL+ P +I + G H I+++D ++ + + G NK I ++ F ED + + Sbjct: 49 ALEVTPDRS-MIAAAGYQH-IRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGG 106 Query: 226 FDRSVKIWDTETGKVKT-RLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQG 284 D + +IWD + ++ R+ + P + N E IVG + I +D + N+ Sbjct: 107 EDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQ 166 Query: 285 LVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW--------ENQINVPIKQISDTAQ 336 L+ + SI + PD S + + +W E +P +I + Sbjct: 167 LIPEPE---VSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTR 223 Query: 337 HSMPFLNVHPSQNYFCAQSMDN-----RIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAF 391 +++ P S D R +FSL + K G SS G+ AF Sbjct: 224 YALQ-CRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSI--KSGNPGESSRGWMWGCAF 280 Query: 392 SGDGRYICSGDSKSRLFTW 410 SGD +YI + S + W Sbjct: 281 SGDSQYIVTASSDNLARLW 299 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 49/245 (20%), Positives = 90/245 (36%), Gaps = 38/245 (15%) Query: 221 FLSSSFDRSVKIWDTETGKV-KTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRV 279 ++ +D +V+ W +G +T H +S V + P ++ + + + D Sbjct: 17 LATAGYDHTVRFWQAHSGICTRTVQHQDS---QVNALEVTPDRSMIAAAGYQHIRMYDLN 73 Query: 280 SENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWEN-----------QINVPI 328 S N + +YD +I ++ + DG + ED T RIW+ Q+N PI Sbjct: 74 SNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPI 133 Query: 329 KQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGIS 388 + +HP+Q I+ + LK + + I + S S Sbjct: 134 NCVC-----------LHPNQAELIVGDQSGAIHIWDLKTDHNE--QLIPEPEVSI---TS 177 Query: 389 LAFSGDGRYICSGDSKSRLFTWDWN------TSRLLNNIKIPG-NKPITQVDWHPQETSK 441 D Y+ + +S + W+ ++L+ KIP + Q + P T Sbjct: 178 AHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLL 237 Query: 442 VICSG 446 CS Sbjct: 238 ATCSA 242 Score = 30.0 bits (66), Expect = 2.0, Method: Compositional matrix adjust. Identities = 25/100 (25%), Positives = 44/100 (44%), Gaps = 13/100 (13%) Query: 150 LPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQ-GHNKP 208 +PK I P H +F P + L+ + D T KIW ++ + + P Sbjct: 213 IPKTKI---PAHTRYALQCRFSPDS-TLLATCSADQTCKIWR-TSNFSLMTELSIKSGNP 267 Query: 209 IKALR-------FTEDCQSFLSSSFDRSVKIWDTETGKVK 241 ++ R F+ D Q +++S D ++W ETG++K Sbjct: 268 GESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIK 307 >3JZG-A nrPDB Length = 402 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 51/280 (18%), Positives = 109/280 (38%), Gaps = 37/280 (13%) Query: 150 LPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD--YECLRDFQGHNK 207 + + I++Y GH LKF P+ +L+LS DH +++W+ D +GH Sbjct: 139 ITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRD 198 Query: 208 PIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGL 267 + + + + +S D S+K+W ++ ++ +N+ + P + + Sbjct: 199 EVLSADYDLLGEKIMSCGMDHSLKLW-----RINSKRMMNAIKESYDYNPNKTNRPFI-- 251 Query: 268 SNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE------ 321 S+ +H+ D T D H + + +++ G +S S + + W+ Sbjct: 252 --SQKIHFPD--------FSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWKPGKMED 299 Query: 322 -------NQINVPIKQISDTAQHSMPFLNVHPS--QNYFCAQSMDNRIYSFSLKPKYKRH 372 ++ NV I D +Q + ++ Q + ++Y + L+ + Sbjct: 300 DIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHK 359 Query: 373 PKKIFKGHSSAGYGI-SLAFSGDGRYICSGDSKSRLFTWD 411 K H G I +FS D + + + ++ WD Sbjct: 360 AKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 399 >2HES-X nrPDB Length = 330 Score = 48.1 bits (113), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 53/224 (23%), Positives = 95/224 (42%), Gaps = 24/224 (10%) Query: 155 IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIW------DFYHDYECLRDFQGHNKP 208 + + H + ++ + P T L+ +G D T+ IW D + + L +GH Sbjct: 51 VLDETAHKKAIRSVAWRPHTS-LLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENE 109 Query: 209 IKALRFTEDCQSFLSSSFDRSVKIWDT-ETGKVKTRLH-LNSTPADVESRPTNPHEFIVG 266 +K + ++ D + S D+SV IW+T E+G+ + L DV+ +P E ++ Sbjct: 110 VKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLA 169 Query: 267 LSNSKILHYDDRV------SENQGLVQTYDHHLSSILALKYFPDGSKF--ISSSEDKTVR 318 S+ YDD V ++ V + H ++ + + F S S+D TVR Sbjct: 170 SSS-----YDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVR 224 Query: 319 IWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYS 362 +W+ + Q + +P +VH Q Y A + I S Sbjct: 225 VWKYMGDDEDDQQEWVCEAILP--DVHKRQVYNVAWGFNGLIAS 266 Score = 33.5 bits (75), Expect = 0.18, Method: Compositional matrix adjust. Identities = 41/190 (21%), Positives = 69/190 (36%), Gaps = 44/190 (23%) Query: 177 LILSGGNDHTIKIWDFYHDYECLRDF---QGHNKPIKALRFTEDCQSFLSSSFDRSVKIW 233 ++ +G D IK+ +D L D H K I+++ + + SFD +V IW Sbjct: 26 ILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSFDSTVSIW 85 Query: 234 DTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHL 293 E DR E L+ + H Sbjct: 86 AKEESA-------------------------------------DRTFE-MDLLAIIEGHE 107 Query: 294 SSILALKYFPDGSKFISSSEDKTVRIWE-NQINVPIKQISDTAQHSMPFLNV--HPSQNY 350 + + + + DG + S DK+V IWE ++ + IS +HS +V HPS+ Sbjct: 108 NEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEAL 167 Query: 351 FCAQSMDNRI 360 + S D+ + Sbjct: 168 LASSSYDDTV 177 >4A11-B nrPDB Length = 408 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 45/177 (25%), Positives = 75/177 (42%), Gaps = 19/177 (10%) Query: 161 HPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD-----YECL------RDF-QGHNKP 208 H G L P G +LSGG+D I ++D + Y C RD H Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 209 IKALR-FTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFI--V 265 ++ ++ + D F SSSFD+++K+WDT T + + T P + + V Sbjct: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAV 161 Query: 266 GLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFIS-SSEDKTVRIWE 321 G K+ D + ++Q H ILA+ + P ++ +S D V++W+ Sbjct: 162 GTRGPKVQLCDLKSGSCSHILQG---HRQEILAVSWSPRYDYILATASADSRVKLWD 215 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 20/95 (21%), Positives = 38/95 (40%), Gaps = 15/95 (15%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDF---------------QG 204 GH + A+ + P+ +++ + D +K+WD CL Sbjct: 184 GHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTA 243 Query: 205 HNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGK 239 HN + L FT D L+ D +++W++ G+ Sbjct: 244 HNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE 278 >6EOJ-D nrPDB Length = 470 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 39/167 (23%), Positives = 71/167 (42%), Gaps = 4/167 (2%) Query: 156 RNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFT 215 R GH + + P+ G LI S D+ +K+WD C+ + RF Sbjct: 213 RVLSGHHWDVKSCDWHPEMG-LIASASKDNLVKLWD-PRSGNCISSILKFKHTVLKTRFQ 270 Query: 216 EDCQSFLSS-SFDRSVKIWDTETGKVKTRLHLNSTP-ADVESRPTNPHEFIVGLSNSKIL 273 + L + S D+S +++D + + T +E P N F + + + Sbjct: 271 PTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGSLK 330 Query: 274 HYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 H+D + N+ ++ H I +L Y P G F ++++D+T+R W Sbjct: 331 HFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRTIRFW 377 Score = 38.1 bits (87), Expect = 0.007, Method: Compositional matrix adjust. Identities = 38/166 (22%), Positives = 82/166 (49%), Gaps = 12/166 (7%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDF-QGHNKPIKALRFTEDC 218 H T +K+ + +I SG D IKIW ++ +++ H + I+ + F+ + Sbjct: 133 AHDSAVTTMKYSHDSDWMI-SGDADGMIKIWQ--PNFSMVKEIDAAHTESIRDMAFSSND 189 Query: 219 QSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLS--NSKILHYD 276 F++ S D +KIW+ GK + R+ L+ DV+S +P ++ + ++ + +D Sbjct: 190 SKFVTCSDDNILKIWNFSNGK-QERV-LSGHHWDVKSCDWHPEMGLIASASKDNLVKLWD 247 Query: 277 DRVSENQGLVQTYDHHLSSILALKYFP-DGSKFISSSEDKTVRIWE 321 R + + H ++L ++ P G+ ++ S+DK+ R+++ Sbjct: 248 PRSGNCISSILKFKH---TVLKTRFQPTKGNLLMAISKDKSCRVFD 290 Score = 28.5 bits (62), Expect = 5.9, Method: Compositional matrix adjust. Identities = 26/120 (21%), Positives = 52/120 (43%), Gaps = 3/120 (2%) Query: 202 FQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPH 261 Q H+ + ++++ D +S D +KIW VK ++ + +N Sbjct: 131 MQAHDSAVTTMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDS 190 Query: 262 EFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321 +F V S+ IL + + Q V + HH + + + P+ S+S+D V++W+ Sbjct: 191 KF-VTCSDDNILKIWNFSNGKQERVLS-GHHW-DVKSCDWHPEMGLIASASKDNLVKLWD 247 >4G56-B nrPDB Length = 357 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 41/163 (25%), Positives = 67/163 (41%), Gaps = 9/163 (5%) Query: 175 GHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQS-FLSSSFDRSVKIW 233 G +SGG D ++K+WD L+ + H+ + + + FLS D + +W Sbjct: 151 GTQAVSGGKDFSVKVWDLSQK-AVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLW 209 Query: 234 DTETGKVKTRLHL---NSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYD 290 DT K TR+ ++ P V P F G + + + N QT Sbjct: 210 DTRKPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLVNIK---NPDSAQTSA 266 Query: 291 HHLSSILALKYFPDGSKFISS-SEDKTVRIWENQINVPIKQIS 332 H +I L Y S F++S SED TV + + + + +S Sbjct: 267 VHSQNITGLAYSYHSSPFLASISEDCTVAVLDADFSEVFRDLS 309 Score = 31.2 bits (69), Expect = 1.0, Method: Compositional matrix adjust. Identities = 27/119 (22%), Positives = 51/119 (42%), Gaps = 6/119 (5%) Query: 164 GTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQG---HNKPIKALRFTEDCQS 220 G T + ++ + G L+ S + +++W+ L + H+ +K L D Sbjct: 96 GVTDVAWVSEKGILVAS--DSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSDGTQ 153 Query: 221 FLSSSFDRSVKIWDTETGKVKTRLHLNSTPAD-VESRPTNPHEFIVGLSNSKILHYDDR 278 +S D SVK+WD V + +S+ + V + P F+ + +IL +D R Sbjct: 154 AVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTR 212 >6E29-D nrPDB Length = 345 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 55/262 (20%), Positives = 101/262 (38%), Gaps = 37/262 (14%) Query: 154 VIRNYPGHPEGT------TALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNK 207 ++++YP + T T ++F + G + SG D T+ IWD R +GH+K Sbjct: 11 LLQDYPENITNTIRSGHSTCVRF-NRKGDFLASGRVDGTVVIWDL-ETMGVARKLRGHSK 68 Query: 208 PIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGL 267 I +L ++ + LS+ V +WD + GK + + E P N H+F L Sbjct: 69 NITSLSWSRCGRYLLSACQGWKVILWDLQDGKRYREVRFRAPVYGAELHPWNHHQFAAAL 128 Query: 268 SNSKILHYDDRVSENQGLVQTYDHHLSSILALKY-FPDGSKFISSSEDKTVRIWENQINV 326 + + D ++ + ++Y P K S+ D +R Sbjct: 129 FEDQPMLVD----------------ITEPVEVRYVLPSVPKRTSTETDPALR-------- 164 Query: 327 PIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYG 386 KQ + A+H + S ++ A + R+ + + + +KI G + Sbjct: 165 -EKQAKEDAKHMTTAIVYTASGDHLLAGTTKGRLNIIDARTREIIYSEKIASGIITT--- 220 Query: 387 ISLAFSGDGRYICSGDSKSRLF 408 + L SG + + D R F Sbjct: 221 LRLTESGRELLVNAQDRIIRTF 242 >3C9C-A nrPDB Length = 432 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 43/175 (24%), Positives = 81/175 (46%), Gaps = 16/175 (9%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF------YHDYECLRDFQGHNKPIKALR 213 GH + L + P +LS +DHTI +WD + + F GH ++ + Sbjct: 181 GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 240 Query: 214 FTEDCQS-FLSSSFDRSVKIWDTETGKVKTRLH-LNSTPADVESRPTNPH-EFIV--GLS 268 + +S F S + D+ + IWDT H +++ A+V NP+ EFI+ G + Sbjct: 241 WHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSA 300 Query: 269 NSKILHYDDRVSENQGL-VQTYDHHLSSILALKYFPDGSKFISSS-EDKTVRIWE 321 + + +D R N L + +++ H I +++ P ++SS D+ + +W+ Sbjct: 301 DKTVALWDLR---NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWD 352 >5WYJ-BC nrPDB Length = 817 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 40/190 (21%), Positives = 77/190 (40%), Gaps = 42/190 (22%) Query: 158 YPGHPEGTTALKF--LPKTGH--LILSGGNDHTIKIWDF-----YHDYECLRDFQ----G 204 Y GH TA+ + G+ +L+ ND TIK W D + ++ + Sbjct: 430 YIGHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHA 489 Query: 205 HNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFI 264 H K I AL + + F ++S+D++ KIW+ E G+++ L + Sbjct: 490 HEKDINALSVSPNDSIFATASYDKTCKIWNLENGELEATLANHKR--------------- 534 Query: 265 VGLSNSKILHYDDRVSENQG-------------LVQTYDHHLSSILALKYFPDGSKFISS 311 GL + YD ++ + G +++T + H +++ + + IS Sbjct: 535 -GLWDVSFCQYDKLLATSSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCSFINKQKQLISC 593 Query: 312 SEDKTVRIWE 321 D ++IW+ Sbjct: 594 GADGLIKIWD 603 Score = 44.7 bits (104), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 27/80 (33%), Positives = 35/80 (43%), Gaps = 2/80 (2%) Query: 154 VIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALR 213 V++ GH F+ K LI S G D IKIWD ECL+ GHN + AL Sbjct: 567 VMKTLEGHTNAVQRCSFINKQKQLI-SCGADGLIKIWDCSSG-ECLKTLDGHNNRLWALS 624 Query: 214 FTEDCQSFLSSSFDRSVKIW 233 D +S+ D + W Sbjct: 625 TMNDGDMIVSADADGVFQFW 644 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 37/163 (22%), Positives = 66/163 (40%), Gaps = 5/163 (3%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQ 219 H + AL P + + D T KIW+ + E H + + + F + + Sbjct: 489 AHEKDINALSVSPNDS-IFATASYDKTCKIWNL-ENGELEATLANHKRGLWDVSFCQYDK 546 Query: 220 SFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRV 279 +SS D++VKIW +T V L ++ S + I ++ I +D Sbjct: 547 LLATSSGDKTVKIWSLDTFSVMKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWDCSS 606 Query: 280 SENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWEN 322 E ++T D H + + AL DG +S+ D + W++ Sbjct: 607 GE---CLKTLDGHNNRLWALSTMNDGDMIVSADADGVFQFWKD 646 >5FA5-B nrPDB Length = 367 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 35/157 (22%), Positives = 67/157 (42%), Gaps = 9/157 (5%) Query: 174 TGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQS-FLSSSFDRSVKI 232 +G +SG D IK+WD L ++ H + + + S FLS S D + + Sbjct: 161 SGTQAVSGSKDICIKVWDLAQQV-VLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILL 219 Query: 233 WDTETGKVKTRLHLNS---TPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTY 289 WDT K +++ ++ P + P F+ G N + D + + V + Sbjct: 220 WDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTK---STSCVLSS 276 Query: 290 DHHLSSILALKYFPDGSKFISS-SEDKTVRIWENQIN 325 H + L + P F++S SED ++ + ++ ++ Sbjct: 277 AVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLS 313 Score = 34.3 bits (77), Expect = 0.11, Method: Compositional matrix adjust. Identities = 20/70 (28%), Positives = 34/70 (48%), Gaps = 2/70 (2%) Query: 282 NQGLVQTYDHHLSSILALKYFP-DGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMP 340 Q ++ +Y H + + + P S F+S SED + +W+ + P QI +A +P Sbjct: 181 QQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLP 240 Query: 341 F-LNVHPSQN 349 L HP Q+ Sbjct: 241 TSLAWHPQQS 250 >5OQL-d nrPDB Length = 446 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 69/274 (25%), Positives = 112/274 (40%), Gaps = 36/274 (13%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQ 219 GH +G ++ + + I SG D +K+WD E HN +K L FT D + Sbjct: 64 GHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTFTND-K 122 Query: 220 SFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADV--ESRPTNPHEFIVGLSNSKILHYDD 277 LS + D +K+WD N+TP E P F + Sbjct: 123 KLLSCATD-GIKLWDPYASPS------NTTPIATWQEGGPYTSLSFHRSANTFA------ 169 Query: 278 RVSENQGLVQTYD-HHLSSILALKY--FPD-----------GSKFISSSEDKTVRIWENQ 323 S QG ++ +D H ++ A+++ F D S S + D+++ +++ + Sbjct: 170 -ASSGQGCIRIWDLEHSTAGQAIQWPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLR 228 Query: 324 INVP-IKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSS 382 N+P IK + A + + F N + N A S D+ IY F + K I KGH + Sbjct: 229 TNMPVIKTVLHFACNRIVF-NPMEAMNLAVA-SEDHNIYIFDARNFDK--ALNIQKGHVA 284 Query: 383 AGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSR 416 A + + +G+ S D RL+ D SR Sbjct: 285 AVMDVEFSPTGEELVSGSYDRTIRLWRRDAGHSR 318 >5BJS-A nrPDB Length = 605 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 23/86 (26%), Positives = 43/86 (50%), Gaps = 5/86 (5%) Query: 153 KVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYE-----CLRDFQGHNK 207 K+ R GH G L P ++I S +D TI+IW ++E C+ +GH+ Sbjct: 169 KLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSY 228 Query: 208 PIKALRFTEDCQSFLSSSFDRSVKIW 233 + ++ F ++ + LS+ D+ + +W Sbjct: 229 DLLSVAFHDNGRYVLSAGHDQVINLW 254 Score = 31.6 bits (70), Expect = 0.81, Method: Compositional matrix adjust. Identities = 20/71 (28%), Positives = 33/71 (46%), Gaps = 2/71 (2%) Query: 342 LNVHPSQNYFCAQSMDNR-IYSFSLKPKYKRHPKKIFKGHSSAGYGI-SLAFSGDGRYIC 399 L P+ Y A + D+ I +SL P++++ P G Y + S+AF +GRY+ Sbjct: 184 LATSPANPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVL 243 Query: 400 SGDSKSRLFTW 410 S + W Sbjct: 244 SAGHDQVINLW 254 >3ACP-A nrPDB Length = 417 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 29/103 (28%), Positives = 47/103 (45%), Gaps = 12/103 (11%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQ 219 H T LKF P +G ++S D +KIW D R GH + + + + Sbjct: 134 AHVSEITKLKFFP-SGEALISSSQDMQLKIWSV-KDGSNPRTLIGHRATVTDIAIIDRGR 191 Query: 220 SFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHE 262 + LS+S D ++++W+ TG T +H +R NPH+ Sbjct: 192 NVLSASLDGTIRLWECGTG---TTIH-------TFNRKENPHD 224 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 22/68 (32%), Positives = 34/68 (50%), Gaps = 3/68 (4%) Query: 253 VESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSS 312 V++ FI+G + I D + + + Q H+S I LK+FP G ISSS Sbjct: 99 VDTAKLQMRRFILGTTEGDIKVLDSNFNLQREIDQA---HVSEITKLKFFPSGEALISSS 155 Query: 313 EDKTVRIW 320 +D ++IW Sbjct: 156 QDMQLKIW 163 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 30/144 (20%), Positives = 51/144 (35%), Gaps = 48/144 (33%) Query: 179 LSGGNDHTIKIWDFYHDYECLRDF-QGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTET 237 + G + IK+ D ++ R+ Q H I L+F ++ +SSS D +KIW + Sbjct: 110 ILGTTEGDIKVLD--SNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKD 167 Query: 238 GKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSIL 297 G +NP I H +++ Sbjct: 168 G-------------------SNPRTLI--------------------------GHRATVT 182 Query: 298 ALKYFPDGSKFISSSEDKTVRIWE 321 + G +S+S D T+R+WE Sbjct: 183 DIAIIDRGRNVLSASLDGTIRLWE 206 >5OQL-L nrPDB Length = 557 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 38/174 (21%), Positives = 78/174 (44%), Gaps = 12/174 (6%) Query: 154 VIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALR 213 +++ + H + K+ P ++S +D T+++WD + + R F GH ++ Sbjct: 136 ILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSN-DPTRLFTGHTDYVRCGA 194 Query: 214 F---TEDCQSFLSSSFDRSVKIWDTET--GKVKTRLHLNSTPADVESRPTNPHEFIVGLS 268 F + + +S S+D +V++WD G V T H + DV P+ ++ S Sbjct: 195 FMPGSANSNLLVSGSYDETVRVWDARAPGGAVMTFKHADPI-EDVLPLPSG--TTLLAAS 251 Query: 269 NSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWEN 322 + I D ++ L+ +H ++ +L G + +S S D V+++E Sbjct: 252 GNAISVLDLVAAKPLRLIT---NHQKTVTSLSLASQGRRVVSGSLDGHVKVFET 302 Score = 28.9 bits (63), Expect = 5.3, Method: Compositional matrix adjust. Identities = 19/77 (24%), Positives = 37/77 (48%), Gaps = 2/77 (2%) Query: 254 ESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFP-DGSKFISSS 312 E RP + + G ++ +D +++T+ H + K+ P + + +S S Sbjct: 106 EIRP-DGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCS 164 Query: 313 EDKTVRIWENQINVPIK 329 +DKTVR+W+ N P + Sbjct: 165 DDKTVRLWDLPSNDPTR 181 >3CFV-B nrPDB Length = 414 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 43/161 (26%), Positives = 78/161 (48%), Gaps = 17/161 (10%) Query: 174 TGHLILSGGNDHTIKIWDFYHD------YECLRDFQGHNKPIKALRFTEDCQS-FLSSSF 226 +GHL LS +DHT+ +WD + F GH+ ++ + + +S F S + Sbjct: 192 SGHL-LSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVAD 250 Query: 227 DRSVKIWDTETGKVKTRLHL-NSTPADVESRPTNPH-EFIV--GLSNSKILHYDDRVSEN 282 D+ + IWDT + HL ++ A+V NP+ EFI+ G ++ + +D R N Sbjct: 251 DQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR---N 307 Query: 283 QGL-VQTYDHHLSSILALKYFPDGSKFISSS-EDKTVRIWE 321 L + T++ H I + + P ++SS D+ + +W+ Sbjct: 308 LKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWD 348 >5Y1U-A nrPDB Length = 456 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 43/175 (24%), Positives = 81/175 (46%), Gaps = 16/175 (9%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFY------HDYECLRDFQGHNKPIKALR 213 GH + L + P +LS +DHTI +WD + F GH ++ + Sbjct: 206 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 265 Query: 214 FTEDCQS-FLSSSFDRSVKIWDTETGKVKTRLH-LNSTPADVESRPTNPH-EFIV--GLS 268 + +S F S + D+ + IWDT + H +++ A+V NP+ EFI+ G + Sbjct: 266 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 325 Query: 269 NSKILHYDDRVSENQGL-VQTYDHHLSSILALKYFPDGSKFISSS-EDKTVRIWE 321 + + +D R N L + +++ H I +++ P ++SS D+ + +W+ Sbjct: 326 DKTVALWDLR---NLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 377 >5K0Y-T nrPDB Length = 329 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 26/90 (28%), Positives = 42/90 (46%), Gaps = 2/90 (2%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQ 219 GH T +K+ + G L+ + D + +W + + E L + GH + + D + Sbjct: 8 GHERSITQIKY-NREGDLLFTVAKDPIVNVW-YSVNGERLGTYMGHTGAVWCVDADWDTK 65 Query: 220 SFLSSSFDRSVKIWDTETGKVKTRLHLNST 249 L+ S D S ++WD ETGK L NS Sbjct: 66 HVLTGSADNSCRLWDCETGKQLALLKTNSA 95 Score = 35.4 bits (80), Expect = 0.051, Method: Compositional matrix adjust. Identities = 30/137 (21%), Positives = 62/137 (45%), Gaps = 18/137 (13%) Query: 197 ECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESR 256 E L + + H++ I ++ + + F+++S D + K++D+ T + + P ++ + Sbjct: 179 EVLVNVKEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFR-TEPPRELAAL 237 Query: 257 PTNPHEFIVG---------LSNSKILHYDDRV-----SENQGLVQTYDHHLSSILALKYF 302 N +VG ++++I ++ R E G V+ H I ++ + Sbjct: 238 SPNYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKG---HFGPINSVAFH 294 Query: 303 PDGSKFISSSEDKTVRI 319 PDG + S ED VRI Sbjct: 295 PDGKSYSSGGEDGYVRI 311 >4OWR-A nrPDB Length = 339 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 28/103 (27%), Positives = 47/103 (45%), Gaps = 6/103 (5%) Query: 255 SRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSED 314 S PT P F++ S + + + Q + + H +L + + DGSK ++S D Sbjct: 19 SPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCD 78 Query: 315 KTVRIWENQINVPIKQISDTAQHSMPFLNVH--PSQNYFCAQS 355 KT ++W+ N I+ AQH P +H + NY C + Sbjct: 79 KTAKMWDLSSNQAIQ----IAQHDAPVKTIHWIKAPNYSCVMT 117 Score = 33.9 bits (76), Expect = 0.17, Method: Compositional matrix adjust. Identities = 18/74 (24%), Positives = 38/74 (51%), Gaps = 4/74 (5%) Query: 175 GHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTE--DCQSFLSSSFDRSVKI 232 G + + D T K+WD + + ++ Q H+ P+K + + + + ++ S+D+++K Sbjct: 69 GSKVFTASCDKTAKMWDLSSN-QAIQIAQ-HDAPVKTIHWIKAPNYSCVMTGSWDKTLKF 126 Query: 233 WDTETGKVKTRLHL 246 WDT + L L Sbjct: 127 WDTRSSNPMMVLQL 140 >4XYI-A nrPDB Length = 430 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 20/76 (26%), Positives = 37/76 (48%), Gaps = 1/76 (1%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFT-EDC 218 H + + F P +L+ + DHT+ +WD + L +GH + ++++ D Sbjct: 279 AHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLNQRLHTLEGHEDEVYNVQWSPHDE 338 Query: 219 QSFLSSSFDRSVKIWD 234 ++SS DR V +WD Sbjct: 339 PILVTSSTDRRVCVWD 354 >4XFV-A nrPDB Length = 792 Score = 41.6 bits (96), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 41/193 (21%), Positives = 74/193 (38%), Gaps = 22/193 (11%) Query: 152 KKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF--YHDYECLRDFQGHNKPI 209 K V GH T ++F+P + ++ S DH +KIW F Y +C++ Q ++K I Sbjct: 53 KGVYATLKGHEAEVTCVRFVPDSDFMV-SASEDHHVKIWKFTDYSHLQCIQTIQHYSKTI 111 Query: 210 KALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNST-------PADVESRPTNPHE 262 AL S D ++ IW + L T P + + Sbjct: 112 VALSALPSLISV--GCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVEEKK 169 Query: 263 FIVGLSNSKI------LHYDDRVSENQGLVQTYDHHLSSILALKY----FPDGSKFISSS 312 +++ + + + D E +V + H + +L + P S S Sbjct: 170 YLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGS 229 Query: 313 EDKTVRIWENQIN 325 +D+ +R+W +IN Sbjct: 230 QDRYIRLWRIRIN 242 Score = 34.3 bits (77), Expect = 0.10, Method: Compositional matrix adjust. Identities = 17/59 (28%), Positives = 30/59 (50%), Gaps = 1/59 (1%) Query: 264 IVGLSNSKILHYDDRVS-ENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321 IV K + D + N+G+ T H + + +++ PD +S+SED V+IW+ Sbjct: 33 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWK 91 Score = 32.7 bits (73), Expect = 0.37, Method: Compositional matrix adjust. Identities = 18/58 (31%), Positives = 28/58 (48%), Gaps = 2/58 (3%) Query: 178 ILSGGNDHTIKIWDFY--HDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIW 233 I++ G TI +WD ++ +GH + +RF D +S+S D VKIW Sbjct: 33 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIW 90 Score = 29.3 bits (64), Expect = 3.6, Method: Compositional matrix adjust. Identities = 28/124 (22%), Positives = 45/124 (36%), Gaps = 25/124 (20%) Query: 342 LNVHPSQNYFCAQSMDN-------RIYS----FSLKPKYKRHPKKIFKGHSSAGYGISLA 390 L++ P Q + N RI+S +KP H I + L Sbjct: 568 LDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITR----------LK 617 Query: 391 FSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQV----DWHPQETSKVICSG 446 FS DG+++ S + W+ N ++ KP T++ DW P E V + Sbjct: 618 FSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTA 677 Query: 447 AAGK 450 + K Sbjct: 678 SRDK 681 >4BH6-A nrPDB Length = 308 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 44/187 (23%), Positives = 78/187 (41%), Gaps = 10/187 (5%) Query: 140 REERISFR-CYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYEC 198 R+ RI R +P H + LK+ L SGGND+ + +++ Sbjct: 122 RDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLA-SGGNDNVVHVYEGTSKSPI 180 Query: 199 LRDFQGHNKPIKALRFTEDCQSFLSS---SFDRSVKIWDTETGKVKTRLHLNSTPAD-VE 254 L F H +KA+ ++ + L++ + DR +KIW+ T + + S + V Sbjct: 181 LT-FDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVW 239 Query: 255 SRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSED 314 S+ TN G S + +D + + H +L L DG+ +S + D Sbjct: 240 SKNTNELVTSHGYSKYNLTLWD---CNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGD 296 Query: 315 KTVRIWE 321 +T+R W+ Sbjct: 297 ETLRYWK 303 Score = 37.4 bits (85), Expect = 0.015, Method: Compositional matrix adjust. Identities = 56/296 (18%), Positives = 100/296 (33%), Gaps = 58/296 (19%) Query: 119 SEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLI 178 +E +Y ++ + + V + + +K IR GH + L + H++ Sbjct: 61 TENEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSW---NNHVL 117 Query: 179 LSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETG 238 SG DH I D + H + + L++ S D V +++ Sbjct: 118 TSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYE---- 173 Query: 239 KVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILA 298 G S S IL T+D H +++ A Sbjct: 174 ---------------------------GTSKSPIL--------------TFDEHKAAVKA 192 Query: 299 LKYFPDGSKFISS---SEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYF-CAQ 354 + + P +++ + D+ ++IW ++ + I +Q N+ S+N Sbjct: 193 MAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQ----ICNMVWSKNTNELVT 248 Query: 355 SMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTW 410 S Y+ +L P I KGHS + L S DG + SG L W Sbjct: 249 SHGYSKYNLTLWDCNSMDPIAILKGHSFR--VLHLTLSNDGTTVVSGAGDETLRYW 302 >6CHG-A nrPDB Length = 312 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 40/175 (22%), Positives = 67/175 (38%), Gaps = 9/175 (5%) Query: 153 KVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKAL 212 K+++ H E L + P + I SG D T++I Y +R GH P+ ++ Sbjct: 45 KMMKLTTTHKECINCLCWSPDS-KCIASGSEDFTVEITHII--YGRIRRLMGHTAPVISI 101 Query: 213 RFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKI 272 + SSS D S+K W +G + +S P + S + Sbjct: 102 CYNNKGNILCSSSMDESIKEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGL 161 Query: 273 LHYDDRVSENQGLVQTYDHH------LSSILALKYFPDGSKFISSSEDKTVRIWE 321 + D S + TYD + I +K+ +G + S D V++WE Sbjct: 162 IRIFDTESGHCLKTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWE 216 Score = 35.0 bits (79), Expect = 0.074, Method: Compositional matrix adjust. Identities = 35/157 (22%), Positives = 63/157 (40%), Gaps = 27/157 (17%) Query: 104 SEQIEVEEVSHFYGKSEK-----------DYQGRGYLYPPNDVDVDLREERISFRCYLPK 152 SE VE YG+ + Y +G + + +D ++E + L Sbjct: 73 SEDFTVEITHIIYGRIRRLMGHTAPVISICYNNKGNILCSSSMDESIKEWHV-----LSG 127 Query: 153 KVIRNYPGHPEGTTALKFLPKTGHLILSGGN-DHTIKIWDFYHDYECLRDF--------Q 203 ++ H + ++ +PK ILS G+ D I+I+D + CL+ + Sbjct: 128 TALKTMSAHSDAVVSID-IPKFDSSILSSGSYDGLIRIFDTESGH-CLKTLTYDKDWIAE 185 Query: 204 GHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKV 240 PI ++F+ + + L S D VK+W+ G V Sbjct: 186 DGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTV 222 >6ELZ-p nrPDB Length = 460 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 26/108 (24%), Positives = 47/108 (43%), Gaps = 25/108 (23%) Query: 150 LPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF----------------- 192 L V + Y GH A+K++ T ++S GND T+++W Sbjct: 132 LSGNVQKQYSGHSGPIRAVKYISNTR--LVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDD 189 Query: 193 -----YHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDT 235 D + L +GH P+ ++ +++ + LS+S+D S+ W T Sbjct: 190 DDEVNIEDGKTLAILEGHKAPVVSIDVSDNSR-ILSASYDNSIGFWST 236 Score = 32.0 bits (71), Expect = 0.57, Method: Compositional matrix adjust. Identities = 20/80 (25%), Positives = 40/80 (50%), Gaps = 8/80 (10%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD---YECLRD----FQGHNKPIKAL 212 GH ++L P+ +++ SG +D T+K+WD Y R+ +G N + A+ Sbjct: 373 GHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYTITREDKSVQKGVNDKVFAV 432 Query: 213 RFTEDCQSFLSSSFDRSVKI 232 ++ E +S+ D+ ++I Sbjct: 433 KWAEKV-GIISAGQDKKIQI 451 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 34/138 (24%), Positives = 59/138 (42%), Gaps = 6/138 (4%) Query: 199 LRDFQGHNKPIKALRF-TEDCQSFLSSSFDRSVKIWDTETGK-VKTRLHLNSTPADVESR 256 L + H P++ + F + D S S D ++K WD T + + TR S + + Sbjct: 280 LSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDTRTTSYSLLSIAQLS 339 Query: 257 PTNPHEFIVGLSNSKILHYDDRVSENQGLVQT-YDHHLSSILALKYFPDGSKFI-SSSED 314 N G S I +D RV + + Q H + + +L P+ + S S D Sbjct: 340 TLNL--LACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHD 397 Query: 315 KTVRIWENQINVPIKQIS 332 TV++W+ + P+ I+ Sbjct: 398 GTVKVWDVRSTSPMYTIT 415 Score = 28.1 bits (61), Expect = 9.4, Method: Compositional matrix adjust. Identities = 11/35 (31%), Positives = 22/35 (62%), Gaps = 1/35 (2%) Query: 289 YDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQ 323 Y H I A+KY + ++ +S+ D+T+R+W+ + Sbjct: 140 YSGHSGPIRAVKYISN-TRLVSAGNDRTLRLWKTK 173 >5A31-R nrPDB Length = 386 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 44/187 (23%), Positives = 78/187 (41%), Gaps = 10/187 (5%) Query: 140 REERISFR-CYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYEC 198 R+ RI R +P H + LK+ L SGGND+ + +++ Sbjct: 191 RDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLA-SGGNDNVVHVYEGTSKSPI 249 Query: 199 LRDFQGHNKPIKALRFTEDCQSFLSS---SFDRSVKIWDTETGKVKTRLHLNSTPAD-VE 254 L F H +KA+ ++ + L++ + DR +KIW+ T + + S + V Sbjct: 250 L-TFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVW 308 Query: 255 SRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSED 314 S+ TN G S + +D + + H +L L DG+ +S + D Sbjct: 309 SKNTNELVTSHGYSKYNLTLWD---CNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGD 365 Query: 315 KTVRIWE 321 +T+R W+ Sbjct: 366 ETLRYWK 372 Score = 36.6 bits (83), Expect = 0.024, Method: Compositional matrix adjust. Identities = 58/305 (19%), Positives = 103/305 (33%), Gaps = 58/305 (19%) Query: 119 SEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLI 178 +E +Y ++ + + V + + +K IR GH + L + H++ Sbjct: 130 TENEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSW---NNHVL 186 Query: 179 LSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETG 238 SG DH I D + H + + L++ S D V +++ Sbjct: 187 TSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYE---- 242 Query: 239 KVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILA 298 G S S IL T+D H +++ A Sbjct: 243 ---------------------------GTSKSPIL--------------TFDEHKAAVKA 261 Query: 299 LKYFPDGSKFISS---SEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYF-CAQ 354 + + P +++ + D+ ++IW ++ + I +Q N+ S+N Sbjct: 262 MAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQ----ICNMVWSKNTNELVT 317 Query: 355 SMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNT 414 S Y+ +L P I KGHS + L S DG + SG L W Sbjct: 318 SHGYSKYNLTLWDCNSMDPIAILKGHSFR--VLHLTLSNDGTTVVSGAGDETLRYWKLFD 375 Query: 415 SRLLN 419 +LN Sbjct: 376 VSVLN 380 >4AEZ-A nrPDB Length = 401 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 33/121 (27%), Positives = 58/121 (47%), Gaps = 8/121 (6%) Query: 209 IKALRFTEDCQSFLSSSFDRS-VKIWDTETGKVKTRLH-LNSTPADVESRPTNPHEFIVG 266 + +++++ D SFLS V I+D E+ +T+L + A V N H G Sbjct: 137 VASVKWSHD-GSFLSVGLGNGLVDIYDVES---QTKLRTMAGHQARVGCLSWNRHVLSSG 192 Query: 267 LSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINV 326 + I H+D R++ +Q + T H S + L + DG + S D V+IW+ + ++ Sbjct: 193 SRSGAIHHHDVRIANHQ--IGTLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSI 250 Query: 327 P 327 P Sbjct: 251 P 251 Score = 31.6 bits (70), Expect = 0.84, Method: Compositional matrix adjust. Identities = 48/212 (22%), Positives = 79/212 (37%), Gaps = 19/212 (8%) Query: 155 IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRF 214 +R GH L + H++ SG I D + QGH+ + L + Sbjct: 169 LRTMAGHQARVGCLSW---NRHVLSSGSRSGAIHHHDVRIANHQIGTLQGHSSEVCGLAW 225 Query: 215 TEDCQSFLSSSFDRSVKIWDTETGKVK-TRLHLNSTPADVESRPTNPHEFIVGLSN-SKI 272 D S D V+IWD + K T+ + N+ V P + G K Sbjct: 226 RSDGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQ 285 Query: 273 LHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSS--EDKTVRIWENQINVPIKQ 330 +H+ + + + V T D S + +L + P + +S+ D + IW + KQ Sbjct: 286 IHFWNAATGAR--VNTVDAG-SQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQ 342 Query: 331 ISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYS 362 + A H ++ + A S D RI S Sbjct: 343 VDIPA---------HDTRVLYSALSPDGRILS 365 Score = 28.5 bits (62), Expect = 5.9, Method: Compositional matrix adjust. Identities = 21/80 (26%), Positives = 35/80 (43%), Gaps = 3/80 (3%) Query: 368 KYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNK 427 + H +GHSS G LA+ DG + SG + + + WD +S + K N Sbjct: 204 RIANHQIGTLQGHSSEVCG--LAWRSDGLQLASGGNDNVVQIWDARSS-IPKFTKTNHNA 260 Query: 428 PITQVDWHPQETSKVICSGA 447 + V W P +++ + G Sbjct: 261 AVKAVAWCPWQSNLLATGGG 280 >5OQL-X nrPDB Length = 630 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 25/93 (26%), Positives = 43/93 (46%), Gaps = 3/93 (3%) Query: 142 ERISFRCYLPKKV-IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLR 200 ERI F +K + Y GH + +K + G +++GG D + +++ D + ++ Sbjct: 225 ERICFAKADARKANDKTYQGHLKAPLVVK-ASQDGKFVVTGGADKRLVVYN-AADLKPIK 282 Query: 201 DFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIW 233 F H + L F S S DR+VK+W Sbjct: 283 AFTQHRDAVTGLAFRRGTNQLYSCSKDRTVKVW 315 >4J0W-A nrPDB Length = 343 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 32/133 (24%), Positives = 59/133 (44%), Gaps = 14/133 (10%) Query: 199 LRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLH-LNSTPADVESRP 257 +R +GH I L T D + S++ D S+ W E+G+ +LH + E +P Sbjct: 7 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGR---KLHVIPRAKKGAEGKP 63 Query: 258 TNPHEFIVGL---SNSKILHYDDR-----VSENQGL--VQTYDHHLSSILALKYFPDGSK 307 ++ + S+ K L DR + E Q + T+ H ++ L + + Sbjct: 64 PGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQ 123 Query: 308 FISSSEDKTVRIW 320 S+S D++V++W Sbjct: 124 LYSTSHDRSVKVW 136 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 23/77 (29%), Positives = 32/77 (41%), Gaps = 2/77 (2%) Query: 159 PGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDC 218 PGH + + G + SG I IW+ + L F GH + L F Sbjct: 64 PGHSSHVLCMA-ISSDGKYLASGDRSKLILIWE-AQSCQHLYTFTGHRDAVSGLAFRRGT 121 Query: 219 QSFLSSSFDRSVKIWDT 235 S+S DRSVK+W+ Sbjct: 122 HQLYSTSHDRSVKVWNV 138 Score = 34.7 bits (78), Expect = 0.081, Method: Compositional matrix adjust. Identities = 23/84 (27%), Positives = 40/84 (47%), Gaps = 10/84 (11%) Query: 336 QHSMPFLNVHPSQNYFCAQSMDNRIYSFSLK--------PKYKRHPKKIFKGHSSAGYGI 387 Q S+ L V P + + + D I +S++ P+ K+ + GHSS + + Sbjct: 14 QLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSS--HVL 71 Query: 388 SLAFSGDGRYICSGDSKSRLFTWD 411 +A S DG+Y+ SGD + W+ Sbjct: 72 CMAISSDGKYLASGDRSKLILIWE 95 Score = 33.5 bits (75), Expect = 0.21, Method: Compositional matrix adjust. Identities = 19/74 (25%), Positives = 35/74 (47%), Gaps = 4/74 (5%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQ 219 GH + AL L + + +GG D T+++W + + + F GH I + + + Sbjct: 149 GHQDAVAALDALSREC-CVTAGGRDGTVRVWKIPEESQLV--FYGHQGSIDCIHLINE-E 204 Query: 220 SFLSSSFDRSVKIW 233 +S + D SV +W Sbjct: 205 HMVSGADDGSVALW 218 >5CXB-B nrPDB Length = 369 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 22/90 (24%), Positives = 44/90 (48%), Gaps = 3/90 (3%) Query: 365 LKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIP 424 LKP + + IF+GH G S+A G + +G + W+ T R + ++K+ Sbjct: 6 LKP-FPTVQQTIFRGHE--GRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLN 62 Query: 425 GNKPITQVDWHPQETSKVICSGAAGKIYVC 454 G++ + V W P + + ++ + A I++ Sbjct: 63 GDEAVNTVRWRPTKDTFILAAAAGEDIFLM 92 >1PI6-A nrPDB Length = 615 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 36/162 (22%), Positives = 66/162 (40%), Gaps = 20/162 (12%) Query: 168 LKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTE---DCQSFLSS 224 ++F P +G +++ G+D I +D E L+ + +P++ F D Q F + Sbjct: 212 VEFSPDSGEFVITVGSDRKISCFD-GKSGEFLKYIEDDQEPVQGGIFALSWLDSQKFATV 270 Query: 225 SFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSEN-- 282 D ++++WD T K + L+ + + N +V N +I+ + N Sbjct: 271 GADATIRVWDVTTSKCVQKWTLD------KQQLGNQQVGVVATGNGRIISLSLDGTLNFY 324 Query: 283 ----QGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 +++T H I AL P IS S D + W Sbjct: 325 ELGHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEW 362 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 18/73 (24%), Positives = 31/73 (42%), Gaps = 8/73 (10%) Query: 370 KRHPKKIFKGH-SSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNK- 427 K P F GH SS + + +Y+CSGD ++ W W + N++++ Sbjct: 52 KVPPVVQFTGHGSSVVTTVKFSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSE 111 Query: 428 ------PITQVDW 434 PI+ + W Sbjct: 112 FQVLAGPISDISW 124 >5WLC-LU nrPDB Length = 489 Score = 37.7 bits (86), Expect = 0.010, Method: Compositional matrix adjust. Identities = 27/136 (19%), Positives = 61/136 (44%), Gaps = 4/136 (2%) Query: 187 IKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSS-FDRSVKIWDTETGKVKTRLH 245 I +WD + + + D I +L+F ++ L+S+ D S+ ++D T ++ Sbjct: 201 IHLWDV-NRLKPVSDLSWGADNITSLKFNQNETDILASTGSDNSIVLYDLRTNSPTQKIV 259 Query: 246 LNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDG 305 + P F+ + +YD R + + H+S+++ + + P G Sbjct: 260 QTMRTNAICWNPMEAFNFVTANEDHNAYYYDMRNLSRS--LNVFKDHVSAVMDVDFSPTG 317 Query: 306 SKFISSSEDKTVRIWE 321 + ++ S DK++RI++ Sbjct: 318 DEIVTGSYDKSIRIYK 333 Score = 35.0 bits (79), Expect = 0.070, Method: Compositional matrix adjust. Identities = 37/170 (21%), Positives = 71/170 (41%), Gaps = 18/170 (10%) Query: 162 PEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQS- 220 + T+LKF ++ S G+D++I ++D LR K ++ +R C + Sbjct: 219 ADNITSLKFNQNETDILASTGSDNSIVLYD-------LRTNSPTQKIVQTMRTNAICWNP 271 Query: 221 -----FLSSSFDRSVKIWDTETGKVKTRLHLNSTPA--DVESRPTNPHEFIVGLSNSKIL 273 F++++ D + +D + + A DV+ PT E + G + I Sbjct: 272 MEAFNFVTANEDHNAYYYDMRNLSRSLNVFKDHVSAVMDVDFSPTGD-EIVTGSYDKSIR 330 Query: 274 HYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQ 323 Y ++ + T + + +KY D IS S+D VR+W ++ Sbjct: 331 IYKTNHGHSREIYHT--KRMQHVFQVKYSMDSKYIISGSDDGNVRLWRSK 378 Score = 33.5 bits (75), Expect = 0.21, Method: Compositional matrix adjust. Identities = 60/292 (20%), Positives = 116/292 (39%), Gaps = 39/292 (13%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTE--- 216 GH +G A+ + + + +G D IK W+ E + F+ H + L T+ Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFV-SFKAHYGLVTGLCVTQPRF 123 Query: 217 -----DCQS---FLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLS 268 D +S LS S D++VK+W + + N +D +S TN I Sbjct: 124 HDKKPDLKSQNFMLSCSDDKTVKLWS-----INVDDYSNKNSSDNDS-VTNEEGLIRTFD 177 Query: 269 NSKILHYDDRVSENQGL------VQTYDHH-----------LSSILALKYFPDGSKFISS 311 D EN + +D + +I +LK+ + + ++S Sbjct: 178 GESAFQGIDSHRENSTFATGGAKIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILAS 237 Query: 312 S-EDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYK 370 + D ++ +++ + N P ++I T + + N + N+ A D+ Y + ++ + Sbjct: 238 TGSDNSIVLYDLRTNSPTQKIVQTMRTNAICWNPMEAFNFVTANE-DHNAYYYDMRNLSR 296 Query: 371 RHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIK 422 +FK H SA + + +GD S D R++ + SR + + K Sbjct: 297 --SLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIYHTK 346 >4U1E-I nrPDB Length = 347 Score = 37.7 bits (86), Expect = 0.011, Method: Compositional matrix adjust. Identities = 39/167 (23%), Positives = 69/167 (41%), Gaps = 34/167 (20%) Query: 175 GHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWD 234 G I++G D I +D ++YE + H K I ++F+ D F++SS D + + D Sbjct: 165 GKYIIAGHKDGKISKYDVSNNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLVD 224 Query: 235 TETGKV----KTRLHLNS---TPA-------------DVESRPTNPHEFIVGLSNSKILH 274 T +V +T LN+ TP DV + N +F ++ H Sbjct: 225 VSTLQVLKKYETDCPLNTAVITPLKEFIILGGGQEAKDVTTTSANEGKF-----EARFYH 279 Query: 275 --YDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRI 319 +++ + QG H + + P G+ + S ED +R+ Sbjct: 280 KIFEEEIGRVQG-------HFGPLNTVAISPQGTSYASGGEDGFIRL 319 Score = 33.5 bits (75), Expect = 0.22, Method: Compositional matrix adjust. Identities = 34/134 (25%), Positives = 56/134 (41%), Gaps = 18/134 (13%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALR---FTE 216 GH T +K+ K G L+ S D + +W + + E L GH I ++ FT+ Sbjct: 8 GHERPLTQVKY-NKEGDLLFSCSKDSSASVW-YSLNGERLGTLDGHTGTIWSIDVDCFTK 65 Query: 217 DCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYD 276 C ++ S D S+K+WD G+ +P V+ +P + L Sbjct: 66 YC---VTGSADYSIKLWDVSNGQCVATW---KSPVPVKRVEFSP-------CGNYFLAIL 112 Query: 277 DRVSENQGLVQTYD 290 D V +N G + Y+ Sbjct: 113 DNVMKNPGSINIYE 126 >2AQ5-A nrPDB Length = 402 Score = 37.4 bits (85), Expect = 0.015, Method: Compositional matrix adjust. Identities = 27/113 (23%), Positives = 47/113 (41%), Gaps = 10/113 (8%) Query: 153 KVIRNYP---GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF------YHDYECLRDFQ 203 +V +N P GH + + P ++I SG D T+ +W+ E + + Sbjct: 69 RVDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLE 128 Query: 204 GHNKPIKALRFTEDCQS-FLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVES 255 GH K + + + Q+ LS+ D + +WD TG L + P + S Sbjct: 129 GHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYS 181 Score = 32.3 bits (72), Expect = 0.44, Method: Compositional matrix adjust. Identities = 38/147 (25%), Positives = 61/147 (41%), Gaps = 19/147 (12%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLR-DFQGHNKPIKALRFTEDC 218 GH + + + P +++LS G D+ I +WD L H I ++ ++ D Sbjct: 129 GHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDG 188 Query: 219 QSFLSSSFDRSVKIWDTETGKV---KTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHY 275 +S D+ V++ + G V K R H + P V +S KIL Sbjct: 189 ALICTSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHA-----------VFVSEGKILTT 237 Query: 276 D-DRVSENQGLVQTYD-HHLSSILALK 300 R+SE Q V +D HL L+L+ Sbjct: 238 GFSRMSERQ--VALWDTKHLEEPLSLQ 262 >5CXC-A nrPDB Length = 510 Score = 36.6 bits (83), Expect = 0.022, Method: Compositional matrix adjust. Identities = 57/271 (21%), Positives = 96/271 (35%), Gaps = 37/271 (13%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWD------FYHDYECLRDFQGHNKPIKALR 213 GH A KFL T + S G D T+++W F + + + GH + L Sbjct: 190 GHTASIKAAKFL--TSDRLASAGMDRTVRVWKYTESDHFTGELKPTLELYGHTGSVDWLD 247 Query: 214 FTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKIL 273 + L++S D ++ W A S P + G SK Sbjct: 248 VDGHSKHILTASADGAIGFWS----------------ASKASAPEPDASLLPGAHVSKRR 291 Query: 274 HYDDRVSENQ-GLVQTYDHHLSSILALKYFP-DGSKFISSSEDKTVRIWENQINVPIKQI 331 VS Q G + + H + A + P D + S+S+D TVR +++ Q+ Sbjct: 292 KATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQDHTVR----TLDLTTGQV 347 Query: 332 SDTAQHSMPFLNVHP-----SQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYG 386 T + P L++ + + A R + + P+ + A Sbjct: 348 VSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITM-VDPRASSATTSVMTLRGHANKV 406 Query: 387 ISLAFSGDGRY-ICSGDSKSRLFTWDWNTSR 416 +SL+ S + Y + SG WD + R Sbjct: 407 VSLSPSPENEYSLVSGSHDGTCRVWDLRSVR 437 >5WLC-LJ nrPDB Length = 513 Score = 36.6 bits (83), Expect = 0.026, Method: Compositional matrix adjust. Identities = 62/311 (19%), Positives = 122/311 (39%), Gaps = 47/311 (15%) Query: 149 YLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKP 208 Y P+ ++ + T KF + ++ + +D ++WD + YE + G Sbjct: 111 YNPRTILLSINASTHPTHVTKFHTQDNKILATASDDRVTRLWDISNAYEPQLELTGATDY 170 Query: 209 IKALRFTEDCQSFLSS-SFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGL 267 ++ L F +++ S+D ++++DT + LN P E ++ + Sbjct: 171 VRTLSFIPAAPHLVATGSYDGLIRLYDTRSSGSTPIYSLNH---------DQPVENVIAV 221 Query: 268 SNSKILHYDDR------VSENQGLVQTYDHHLSSILALKYF-----PDGSKFISSSEDKT 316 S ++I+ ++ N+ L + + + ++ L Y P S I+SS D Sbjct: 222 SPTQIVSCGGNNFKVWDLTSNKKLYERGNFN-KAVTCLDYVENFDSPMQSALIASSLDGH 280 Query: 317 VRIWENQINVPIKQISDTAQHSMPFLN--VHPSQ---NYFCAQSMDNRIYSFSLKPKYKR 371 V++++ N Q+ + S P L+ V PS N + + + + K K KR Sbjct: 281 VKVFDPLDNF---QVKFGWKFSGPVLSCAVSPSTAQGNRHLVAGLSSGLLAIRTKKKEKR 337 Query: 372 ------HPKKIFKGHSSAGYGISL---AFSGDGRYICSGD---SKSRLFTWDWNT----- 414 P K S + + + GD +I D S+ R+ ++ N Sbjct: 338 SSDKENAPASFNKNAKSNNFQRMMRGSEYQGDQEHIIHNDKVRSQRRMRAFERNINQFKW 397 Query: 415 SRLLNNIKIPG 425 S L+N +PG Sbjct: 398 SEALDNAFVPG 408 >2PM9-A nrPDB Length = 416 Score = 35.4 bits (80), Expect = 0.051, Method: Compositional matrix adjust. Identities = 52/234 (22%), Positives = 84/234 (35%), Gaps = 25/234 (10%) Query: 155 IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFY------HDYECLRDFQGHNKP 208 + + H +KF K +++ SGGN+ I IWD +Y L Q + Sbjct: 106 MARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSV 165 Query: 209 IKALRFTED---CQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPAD---------VESR 256 + + + F S+ IWD + K +HL+ T + VE Sbjct: 166 DEVISLAWNQSLAHVFASAGSSNFASIWDLKAK--KEVIHLSYTSPNSGIKQQLSVVEWH 223 Query: 257 PTNPHEFIVGL---SNSKILHYDDRVSENQGLVQTYDHHLSSILALKYF-PDGSKFISSS 312 P N ++ IL +D R + N L H IL+L + D +SS Sbjct: 224 PKNSTRVATATGSDNDPSILIWDLR-NANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSG 282 Query: 313 EDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLK 366 D TV +W + + Q + + F S DN+I +L+ Sbjct: 283 RDNTVLLWNPESAEQLSQFPARGNWCFKTKFAPEAPDLFACASFDNKIEVQTLQ 336 >6BX3-B nrPDB Length = 412 Score = 34.7 bits (78), Expect = 0.081, Method: Compositional matrix adjust. Identities = 25/98 (25%), Positives = 43/98 (43%), Gaps = 19/98 (19%) Query: 151 PKKVIRNYPG-------HPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRD-- 201 P V++ +P +P T L+F P +L L N + +D + R Sbjct: 7 PFAVLKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALV-----IYDMDTFRPIC 61 Query: 202 -----FQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWD 234 H +PI ++ ++ D + L+SS D S+K+WD Sbjct: 62 VPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWD 99 Score = 29.6 bits (65), Expect = 3.1, Method: Compositional matrix adjust. Identities = 12/41 (29%), Positives = 28/41 (68%), Gaps = 1/41 (2%) Query: 292 HLSSILALKYFPDGSKFISSSEDKTVRIWE-NQINVPIKQI 331 H+ I ++ + PDG ++SS D ++++W+ ++ + P+K+I Sbjct: 70 HVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEI 110 Score = 28.5 bits (62), Expect = 5.5, Method: Compositional matrix adjust. Identities = 44/200 (22%), Positives = 76/200 (38%), Gaps = 33/200 (16%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTE--- 216 H T++ + P G L+L+ D +IK+W D +KP+K +RF Sbjct: 69 AHVRPITSIAWSPD-GRLLLTSSRDWSIKLW----------DLSKPSKPLKEIRFDSPIW 117 Query: 217 DCQSF-------LSSSFDRS-VKIWDTETGKVKTRL------HLNSTP-----ADVESRP 257 CQ +++ F+ S + D V + L L+STP Sbjct: 118 GCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDHGYVLVCTVHT 177 Query: 258 TNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTV 317 +P+ IVG S + Y + + S+I L +G + + D+T+ Sbjct: 178 KHPNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTI 237 Query: 318 RIWENQINVPIKQISDTAQH 337 R +E I+ + T +H Sbjct: 238 RQYEISIDDENSAVELTLEH 257 >5N4A-A nrPDB Length = 771 Score = 34.7 bits (78), Expect = 0.087, Method: Compositional matrix adjust. Identities = 42/185 (22%), Positives = 78/185 (42%), Gaps = 18/185 (9%) Query: 271 KILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQ 330 KIL RV ++ + H + ++L++ DG+ ++ ED +V+IW N ++ Sbjct: 88 KILSRTGRVE------KSIEGHKGACISLRWSYDGTALATAGEDGSVKIWSR--NGMLR- 138 Query: 331 ISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLA 390 S AQ P ++ + Y C Q + +K + +K H G + + Sbjct: 139 -STLAQADSPVYSIVWA--YDCDQLCYCTGSNVVIKSLSSNAKQNAWKAHD--GVVLKVD 193 Query: 391 FSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGK 450 +S I +G + WD + RLL + + P+T V W P + ++ G Sbjct: 194 WSPINHLIITGGEDCKYKVWD-SFGRLLFQSGL-FDYPVTSVAWAP--SGELFAVGGFNT 249 Query: 451 IYVCD 455 + +CD Sbjct: 250 LQLCD 254 Score = 30.8 bits (68), Expect = 1.4, Method: Compositional matrix adjust. Identities = 27/125 (21%), Positives = 54/125 (43%), Gaps = 9/125 (7%) Query: 200 RDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTP--ADVESRP 257 + +GH +LR++ D + ++ D SVKIW + G +++ L +P + V + Sbjct: 98 KSIEGHKGACISLRWSYDGTALATAGEDGSVKIW-SRNGMLRSTLAQADSPVYSIVWAYD 156 Query: 258 TNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTV 317 + + G SN I +N + H +L + + P I+ ED Sbjct: 157 CDQLCYCTG-SNVVIKSLSSNAKQN-----AWKAHDGVVLKVDWSPINHLIITGGEDCKY 210 Query: 318 RIWEN 322 ++W++ Sbjct: 211 KVWDS 215 Score = 28.9 bits (63), Expect = 5.4, Method: Compositional matrix adjust. Identities = 19/74 (25%), Positives = 37/74 (50%), Gaps = 4/74 (5%) Query: 176 HLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDT 235 HLI++GG D K+WD + L + P+ ++ + + F F+ ++++ D Sbjct: 199 HLIITGGEDCKYKVWDSFG--RLLFQSGLFDYPVTSVAWAPSGELFAVGGFN-TLQLCD- 254 Query: 236 ETGKVKTRLHLNST 249 G +++HLN T Sbjct: 255 RMGWAYSKIHLNDT 268 >5WYJ-BE nrPDB Length = 939 Score = 34.7 bits (78), Expect = 0.094, Method: Compositional matrix adjust. Identities = 31/152 (20%), Positives = 67/152 (44%), Gaps = 7/152 (4%) Query: 171 LPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSV 230 + + G+ G ++ +I I++ + ++ H + + + + +S D V Sbjct: 468 MSQCGNFGFIGSSNGSITIYNMQSGI-LRKKYKLHKRAVTGISLDGMNRKMVSCGLDGIV 526 Query: 231 KIWDTETGKVKTRLHLNS-TPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTY 289 +D + +L L++ A V R ++ F + L + I+ D + Q +V+ Sbjct: 527 GFYDFNKSTLLGKLKLDAPITAMVYHRSSDL--FALALDDLSIVVID---AVTQRVVRQL 581 Query: 290 DHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321 H + I A + P+G +S+S D T+R W+ Sbjct: 582 WGHSNRITAFDFSPEGRWIVSASLDSTIRTWD 613 Score = 33.9 bits (76), Expect = 0.16, Method: Compositional matrix adjust. Identities = 15/60 (25%), Positives = 31/60 (51%) Query: 198 CLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRP 257 +R GH+ I A F+ + + +S+S D +++ WD TG + +++ +V+ P Sbjct: 577 VVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTGGCIDGIIVDNVATNVKFSP 636 Score = 32.7 bits (73), Expect = 0.34, Method: Compositional matrix adjust. Identities = 16/43 (37%), Positives = 23/43 (53%), Gaps = 1/43 (2%) Query: 150 LPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF 192 + ++V+R GH TA F P+ G I+S D TI+ WD Sbjct: 573 VTQRVVRQLWGHSNRITAFDFSPE-GRWIVSASLDSTIRTWDL 614 >4L9O-A nrPDB Length = 349 Score = 34.7 bits (78), Expect = 0.098, Method: Compositional matrix adjust. Identities = 27/90 (30%), Positives = 44/90 (48%), Gaps = 11/90 (12%) Query: 160 GHPEGTTALKF----LPKTGHLILSGGNDHTIKIWDFYHDYECLRD---FQGHNKPIKAL 212 GH G A + LP +SGG D+ +KIW + + + FQGH+ ++ + Sbjct: 203 GHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSDWVRDV 262 Query: 213 RFTEDCQS---FLSSSFDRSVKIWDTETGK 239 ++ S ++S DR+V IW T+ GK Sbjct: 263 AWSPSRLSKSYIATASQDRTVLIW-TKDGK 291 >5A9Q-7 nrPDB Length = 360 Score = 34.3 bits (77), Expect = 0.10, Method: Compositional matrix adjust. Identities = 18/74 (24%), Positives = 36/74 (48%), Gaps = 4/74 (5%) Query: 175 GHLILSGGNDHTIKIWDFYH--DYECLRDFQGHNKPIKALRFT--EDCQSFLSSSFDRSV 230 G + + +D ++K+WD D+ C ++ H+ + + + E Q S SFDR+ Sbjct: 24 GRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVLASCSFDRTA 83 Query: 231 KIWDTETGKVKTRL 244 +W+ G+ +L Sbjct: 84 AVWEEIVGESNDKL 97 >4YCZ-A nrPDB Length = 876 Score = 33.9 bits (76), Expect = 0.16, Method: Compositional matrix adjust. Identities = 51/218 (23%), Positives = 85/218 (38%), Gaps = 30/218 (13%) Query: 172 PKTGHLILSGGNDHTIKIW-DFYHDYECLRDFQGHNKPIKALRFT--EDCQSFLSSSFDR 228 PK G+++ S G D + IW + ++ + DF H + + ++ E +S D Sbjct: 73 PKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDG 132 Query: 229 SVKI-------WDTETGKVKTRLHLNST---PAD-----VESRP----TNPHEFIVGLSN 269 +V + W+ L +NS PA V S+P T F+ G S+ Sbjct: 133 NVSVLEFRDNSWEHSIFHAHG-LGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSD 191 Query: 270 S--KILHYDDRVSENQGLVQTYDHHLSSILALKYFP---DGSKFISSSEDKTVRIWENQI 324 + KI YD + + + H + + + P S S+SED+TVRIW + Sbjct: 192 NALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDP 251 Query: 325 NVPIKQISDTAQHSMPFLNV--HPSQNYFCAQSMDNRI 360 P++ V S N A DN++ Sbjct: 252 ANPLQWNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKV 289 >3W15-A nrPDB Length = 368 Score = 33.5 bits (75), Expect = 0.22, Method: Compositional matrix adjust. Identities = 27/105 (25%), Positives = 46/105 (43%), Gaps = 14/105 (13%) Query: 176 HLILSGGNDHTIKIWDF---------YHDYECLRDF-QGHNKPIKALRFT-EDCQSFLSS 224 +++ +GG D+ I+IWD H+ C+ + H I+ + ++ +S+ Sbjct: 236 YVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSA 295 Query: 225 SFDRSVKIW-DTETGKVKTRLHLNSTPADVES--RPTNPHEFIVG 266 S+D + +IW D K NST A S T EF+ G Sbjct: 296 SYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFG 340 Score = 29.3 bits (64), Expect = 4.2, Method: Compositional matrix adjust. Identities = 17/57 (29%), Positives = 32/57 (56%), Gaps = 1/57 (1%) Query: 178 ILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFT-EDCQSFLSSSFDRSVKIW 233 +L D T++++D + F+ H + + + + + Q+FLSSS+D S+KIW Sbjct: 78 VLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIW 134 >4FHN-A nrPDB Length = 394 Score = 32.7 bits (73), Expect = 0.31, Method: Compositional matrix adjust. Identities = 20/59 (33%), Positives = 30/59 (50%), Gaps = 1/59 (1%) Query: 219 QSFLSSSFDRSVKIWD-TETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYD 276 Q S D ++ IW T+ G + L+S V+ RP+NP++ IVG N I +D Sbjct: 158 QVIASVGDDCTLIIWRLTDEGPILAGYPLSSPGISVQFRPSNPNQLIVGERNGNIRIFD 216 >3BG0-A nrPDB Length = 316 Score = 32.7 bits (73), Expect = 0.33, Method: Compositional matrix adjust. Identities = 52/267 (19%), Positives = 102/267 (38%), Gaps = 35/267 (13%) Query: 175 GHLILSGGNDHTIKIWDFYHDYECL-RDFQGHNKPIKALRFTEDCQS--FLSSSFDRSVK 231 G + + +D ++KI+D + + L D +GH P+ + + S S+DR V Sbjct: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 84 Query: 232 IWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGL---SNSKILHYDDRVSENQGLVQT 288 IW E G + + V S PH++ + L S+ + E Q V+ Sbjct: 85 IWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 144 Query: 289 YDH-HLSSILALKYFPD---GS--------------KFISSSEDKTVRIWENQINVPIKQ 330 ++ H A+ + P GS +F S D +++W+ + + K+ Sbjct: 145 INNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKE 204 Query: 331 ISDTAQHS--------MPFLNVHPSQNYFCAQSMDNRIYSFSL-KPKYKRHPKKIFKGHS 381 HS P + + S C+Q D R++ ++ K+ + Sbjct: 205 EQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQ--DGRVFIWTCDDASSNTWSPKLLHKFN 262 Query: 382 SAGYGISLAFSGDGRYICSGDSKSRLF 408 + +S + + + + GD+K L+ Sbjct: 263 DVVWHVSWSITANILAVSGGDNKVTLW 289 >4BZK-B nrPDB Length = 297 Score = 32.0 bits (71), Expect = 0.55, Method: Compositional matrix adjust. Identities = 56/264 (21%), Positives = 102/264 (38%), Gaps = 33/264 (12%) Query: 175 GHLILSGGNDHTIKIWDFYHDYECLRD-FQGHNKPIKALRFTED--CQSFLSSSFDRSVK 231 G + + +D TIKI++ + L D GH P+ + + S S+D V Sbjct: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 Query: 232 IWDTETGKVKTRLHLNSTPADVESRPTNPHEF----IVGLSNSK--ILHYDDRVSENQGL 285 IW E G+ A V S PHE+ +V S+ K ++ + + + + + Sbjct: 81 IWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPII 140 Query: 286 VQTYDHHLSSILALKYFP-----DGS--------KFISSSEDKTVRIWENQINVPIKQIS 332 + D H + + + P DG KF++ D V+IW+ + + Sbjct: 141 I---DAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLE 197 Query: 333 DTAQ-HSMPFLNVHPS-----QNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHS--SAG 384 T + HS +V S ++Y + S D ++ + K + K Sbjct: 198 STLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVL 257 Query: 385 YGISLAFSGDGRYICSGDSKSRLF 408 + S + SG+ + GD+K L+ Sbjct: 258 WRASWSLSGNVLALSGGDNKVTLW 281 >3JRP-A nrPDB Length = 379 Score = 31.6 bits (70), Expect = 0.75, Method: Compositional matrix adjust. Identities = 24/74 (32%), Positives = 39/74 (52%), Gaps = 8/74 (10%) Query: 179 LSGGNDHTIKIWDFYHD---YECLRDFQGHNKPIKALRF--TEDCQSFLSS-SFDRSVKI 232 ++GG D+ +KIW + D Y +GH+ ++ + + T +S+L+S S DR+ I Sbjct: 176 VTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCII 235 Query: 233 W--DTETGKVKTRL 244 W D E G K L Sbjct: 236 WTQDNEQGPWKKTL 249 Score = 31.2 bits (69), Expect = 0.88, Method: Compositional matrix adjust. Identities = 56/264 (21%), Positives = 102/264 (38%), Gaps = 33/264 (12%) Query: 175 GHLILSGGNDHTIKIWDFYHDYECLRD-FQGHNKPIKALRFTED--CQSFLSSSFDRSVK 231 G + + +D TIKI++ + L D GH P+ + + S S+D V Sbjct: 23 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 82 Query: 232 IWDTETGKVKTRLHLNSTPADVESRPTNPHEF----IVGLSNSK--ILHYDDRVSENQGL 285 IW E G+ A V S PHE+ +V S+ K ++ + + + + + Sbjct: 83 IWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPII 142 Query: 286 VQTYDHHLSSILALKYFP-----DGS--------KFISSSEDKTVRIWENQINVPIKQIS 332 + D H + + + P DG KF++ D V+IW+ + + Sbjct: 143 I---DAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLE 199 Query: 333 DTAQ-HSMPFLNVHPS-----QNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHS--SAG 384 T + HS +V S ++Y + S D ++ + K + K Sbjct: 200 STLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVL 259 Query: 385 YGISLAFSGDGRYICSGDSKSRLF 408 + S + SG+ + GD+K L+ Sbjct: 260 WRASWSLSGNVLALSGGDNKVTLW 283 >3JRO-A nrPDB Length = 753 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 24/74 (32%), Positives = 39/74 (52%), Gaps = 8/74 (10%) Query: 179 LSGGNDHTIKIWDFYHD---YECLRDFQGHNKPIKALRF--TEDCQSFLSS-SFDRSVKI 232 ++GG D+ +KIW + D Y +GH+ ++ + + T +S+L+S S DR+ I Sbjct: 174 VTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCII 233 Query: 233 W--DTETGKVKTRL 244 W D E G K L Sbjct: 234 WTQDNEQGPWKKTL 247 Score = 29.3 bits (64), Expect = 3.5, Method: Compositional matrix adjust. Identities = 39/169 (23%), Positives = 69/169 (40%), Gaps = 25/169 (14%) Query: 175 GHLILSGGNDHTIKIWDFYHDYECLRD-FQGHNKPIKALRFT--EDCQSFLSSSFDRSVK 231 G + + +D TIKI++ + L D GH P+ + + + S S+D V Sbjct: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 Query: 232 IWDTETGKVKTRLHLNSTPADVESRPTNPHEF----IVGLSNSK--ILHYDDRVSENQGL 285 IW E G+ A V S PHE+ +V S+ K ++ + + + + + Sbjct: 81 IWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPII 140 Query: 286 VQTYDHHLSSILALKYFP-----DGS--------KFISSSEDKTVRIWE 321 + D H + + + P DG KF++ D V+IW+ Sbjct: 141 I---DAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 >5A9Q-2 nrPDB Length = 326 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 14/33 (42%), Positives = 18/33 (54%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF 192 GH + L F PK G I S +DHT +IW+ Sbjct: 122 GHTDFINGLVFDPKEGQEIASVSDDHTCRIWNL 154 Score = 28.1 bits (61), Expect = 7.5, Method: Compositional matrix adjust. Identities = 25/110 (22%), Positives = 47/110 (42%), Gaps = 5/110 (4%) Query: 342 LNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSG 401 L+ P FC + D +I F+ + ++ K+ +GH+ G+ +G+ I S Sbjct: 86 LDSLPPVIKFCTSAADMKIRLFTSDLQ-DKNEYKVLEGHTDFINGLVFD-PKEGQEIASV 143 Query: 402 DSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKI 451 W+ + + + + P V WHP+ET K++ + G I Sbjct: 144 SDDHTCRIWNLEGVQTAHFVL---HSPGMSVCWHPEETFKLMVAEKNGTI 190 >4E5Z-B nrPDB Length = 436 Score = 30.8 bits (68), Expect = 1.4, Method: Compositional matrix adjust. Identities = 44/197 (22%), Positives = 68/197 (34%), Gaps = 34/197 (17%) Query: 153 KVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQG-------- 204 K + N H + T + P + + D T+KIWD LR +G Sbjct: 241 KELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWD-------LRQVRGKASFLYSL 293 Query: 205 -HNKPIKALRFTEDCQSFLSSSFDRSVKI-----WDTETGKV--KTRLHLNSTPADVESR 256 H P+ A F+ D L++ +++ WD G + R + TP Sbjct: 294 PHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWH 353 Query: 257 PTNPHEFIVGL--------SNSKILHYDDRVSENQG--LVQTYDHHLSSILALKYFPDGS 306 P + +VG L D N G + Q YD S I +L F Sbjct: 354 PRY-NLIVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEFNPMG 412 Query: 307 KFISSSEDKTVRIWENQ 323 ++S+ + IW Q Sbjct: 413 DTLASAMGYHILIWSEQ 429 >4YHC-A nrPDB Length = 468 Score = 30.0 bits (66), Expect = 2.1, Method: Compositional matrix adjust. Identities = 23/99 (23%), Positives = 41/99 (41%) Query: 205 HNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFI 264 H I + +E+ ++F S DRS+ +WD K L P +++ +P Sbjct: 29 HQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGNY 88 Query: 265 VGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFP 303 V L + L + S + L +Y +S L + + P Sbjct: 89 VSLFSKDTLFILNVESPSLMLQHSYHSKPNSKLNVFWMP 127 >3JB9-S nrPDB Length = 488 Score = 30.0 bits (66), Expect = 2.3, Method: Compositional matrix adjust. Identities = 20/80 (25%), Positives = 41/80 (51%), Gaps = 2/80 (2%) Query: 175 GHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRS-VKIW 233 G+L ++G + ++ ++ E L F H+ P+K L+F E+ + ++ D S + IW Sbjct: 345 GNLFVAGLENGELRFFETSSGNE-LTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIW 403 Query: 234 DTETGKVKTRLHLNSTPADV 253 D ++ ++ L + A V Sbjct: 404 DLRKSELVQKIPLQTKVAAV 423 >5WLC-SG nrPDB Length = 573 Score = 30.0 bits (66), Expect = 2.4, Method: Compositional matrix adjust. Identities = 17/79 (21%), Positives = 35/79 (44%), Gaps = 1/79 (1%) Query: 288 TYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQI-SDTAQHSMPFLNVHP 346 T + H IL + PDG ++ D+ + +W + P+K I + + + L Sbjct: 231 TTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRK 290 Query: 347 SQNYFCAQSMDNRIYSFSL 365 + + A D +I ++S+ Sbjct: 291 NSDQLYASCADFKIRTYSI 309 >4J0X-A nrPDB Length = 451 Score = 30.0 bits (66), Expect = 2.5, Method: Compositional matrix adjust. Identities = 17/79 (21%), Positives = 35/79 (44%), Gaps = 1/79 (1%) Query: 288 TYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQI-SDTAQHSMPFLNVHP 346 T + H IL + PDG ++ D+ + +W + P+K I + + + L Sbjct: 109 TTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRK 168 Query: 347 SQNYFCAQSMDNRIYSFSL 365 + + A D +I ++S+ Sbjct: 169 NSDQLYASCADFKIRTYSI 187 >6BWX-A nrPDB Length = 537 Score = 29.6 bits (65), Expect = 2.7, Method: Compositional matrix adjust. Identities = 16/35 (45%), Positives = 21/35 (60%), Gaps = 2/35 (5%) Query: 147 RCYLPKKV-IRNYPGHPEGTTALKFLP-KTGHLIL 179 + LP++ + N PG P GT A KFLP + GH L Sbjct: 490 KLRLPRQFNLYNLPGRPRGTEAKKFLPNEIGHFEL 524 >5WLC-LN nrPDB Length = 776 Score = 29.6 bits (65), Expect = 3.1, Method: Compositional matrix adjust. Identities = 19/65 (29%), Positives = 32/65 (49%), Gaps = 4/65 (6%) Query: 167 ALKFLPKTGHLILSGGNDHTIKIWDFYHDYECL-RDFQGHNKPIKALRFTEDCQSFLSSS 225 ++ +LP+T I SG + +IK WDF + L + F+ H+ + L D S+ Sbjct: 243 SVIYLPRTDQ-IASGDSTGSIKFWDF--QFATLNQSFKAHDADVLCLTTDTDNNYVFSAG 299 Query: 226 FDRSV 230 DR + Sbjct: 300 VDRKI 304 >3F3P-A nrPDB Length = 351 Score = 29.3 bits (64), Expect = 3.4, Method: Compositional matrix adjust. Identities = 18/47 (38%), Positives = 30/47 (63%), Gaps = 2/47 (4%) Query: 277 DRVSENQGLVQTYDHHLSSILALKYF-PDGSKFISS-SEDKTVRIWE 321 D+ + N L ++ H SSI+A+ + P+ + I+S S DKTV++WE Sbjct: 41 DKDTSNWELSDSWRAHDSSIVAIDWASPEYGRIIASASYDKTVKLWE 87 >6F1U-h nrPDB Length = 612 Score = 29.3 bits (64), Expect = 3.6, Method: Compositional matrix adjust. Identities = 29/122 (23%), Positives = 55/122 (45%), Gaps = 13/122 (10%) Query: 308 FISSSEDKTVRIWENQINVPIKQISDTAQHSMPFL--NVHPSQNYFCAQSMDNRIYSFSL 365 F++SS D TV++W + N P+ D A + + HP+ + C M R+ ++L Sbjct: 471 FVTSSFDWTVKLWSTKNNKPLYSFEDNAGYVYDVMWSPTHPAL-FACVDGM-GRLDLWNL 528 Query: 366 KPKYKRHPKKI-FKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIP 424 + I +G+ + + ++ GR I GDS+ ++ +D + I +P Sbjct: 529 NNDTEVPTASISVEGNPALN---RVRWTHSGREIAVGDSEGQIVIYD-----VGEQIAVP 580 Query: 425 GN 426 N Sbjct: 581 RN 582 >5A9Q-0 nrPDB Length = 380 Score = 29.3 bits (64), Expect = 3.7, Method: Compositional matrix adjust. Identities = 16/67 (23%), Positives = 28/67 (41%), Gaps = 1/67 (1%) Query: 172 PKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRF-TEDCQSFLSSSFDRSV 230 P H++ +GG D + IWD + + H + + F + + + S D S+ Sbjct: 227 PNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSL 286 Query: 231 KIWDTET 237 WD T Sbjct: 287 WHWDAST 293 >5WLC-LH nrPDB Length = 896 Score = 29.3 bits (64), Expect = 3.7, Method: Compositional matrix adjust. Identities = 18/68 (26%), Positives = 31/68 (45%), Gaps = 17/68 (25%) Query: 292 HLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLN-------- 343 H+ S+L+L + DGS +S +K + +W Q+ +Q +P LN Sbjct: 296 HIDSVLSLSFSHDGSYLLSGGWEKVMSLW---------QLETNSQQFLPRLNGIIIDCQV 346 Query: 344 VHPSQNYF 351 + P NY+ Sbjct: 347 LGPQGNYY 354 >3EI3-B nrPDB Length = 383 Score = 28.9 bits (63), Expect = 5.4, Method: Compositional matrix adjust. Identities = 37/181 (20%), Positives = 71/181 (39%), Gaps = 20/181 (11%) Query: 161 HPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYH--DYECLRDFQGHNKPIKALRFT-ED 217 H T +F P+ L+ + D T+K+WD + D H KP+ A F D Sbjct: 203 HKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNAAYFNPTD 262 Query: 218 CQSFLSSSFDRSVKIWDTETGKVKTRLHLNS-------TPADVESRPTNPHEFIVG--LS 268 L++ ++++ + ++ ++ TP P ++ IV Sbjct: 263 STKLLTTDQRNEIRVYSSYDWSKPDQIIIHPHRQFQHLTPIKATWHPM--YDLIVAGRYP 320 Query: 269 NSKILHYDDRV-----SENQGLV-QTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWEN 322 + ++L D R + + GLV Q D + + I++L F ++S + IW Sbjct: 321 DDQLLLNDKRTIDIYDANSGGLVHQLRDPNAAGIISLNKFSPTGDVLASGMGFNILIWNR 380 Query: 323 Q 323 + Sbjct: 381 E 381 >2VG9-A nrPDB Length = 217 Score = 28.5 bits (62), Expect = 6.4, Method: Compositional matrix adjust. Identities = 21/71 (29%), Positives = 31/71 (43%), Gaps = 2/71 (2%) Query: 387 ISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQ-VDWHPQETSKVI-C 444 I L ++ + S SRL + W +R LN + + I VDW P K++ Sbjct: 73 IGLDYAATYKQTASASGNSRLCVYGWFQNRGLNGVPLVEYYIIEDWVDWVPDAQGKMVTI 132 Query: 445 SGAAGKIYVCD 455 GA KI+ D Sbjct: 133 DGAQYKIFQMD 143 >5YZG-2 nrPDB Length = 646 Score = 28.1 bits (61), Expect = 8.6, Method: Compositional matrix adjust. Identities = 13/60 (21%), Positives = 32/60 (53%) Query: 262 EFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321 +FI+ S+ + + ++ E V+ + HL I ++ +G+ F S +DK +++++ Sbjct: 102 DFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSSEGALFCSVGDDKAMKVFD 161 >3RG2-A nrPDB Length = 617 Score = 28.1 bits (61), Expect = 9.1, Method: Compositional matrix adjust. Identities = 16/78 (20%), Positives = 37/78 (47%), Gaps = 5/78 (6%) Query: 328 IKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGI 387 ++ ++D+ +H++ HP++++ S + + F L PK I + H+ Y + Sbjct: 154 VQLLNDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSV 213 Query: 388 SLA-----FSGDGRYICS 400 + F+ RY+C+ Sbjct: 214 RRSVEICQFTQQTRYLCA 231 >3I2N-A nrPDB Length = 357 Score = 28.1 bits (61), Expect = 9.3, Method: Compositional matrix adjust. Identities = 25/122 (20%), Positives = 49/122 (40%), Gaps = 27/122 (22%) Query: 347 SQNYFCAQSMDNRIYSFSLKPKYKRHPKKIF-----KGHSSAGYGISLAFSGDGRYICSG 401 S N A S++ + + F ++ +HP K F K H S + + ++ +G Sbjct: 223 SMNKLVATSLEGKFHVFDMR---TQHPTKGFASVSEKAHKSTVWQVRHLPQNRELFLTAG 279 Query: 402 DSKS-RLFTWDWNTSR-----------------LLNNIKIPGNKPITQVDWHPQETSKVI 443 + L+ +++ R LL N+ + +PI+ +DW P + + Sbjct: 280 GAGGLHLWKYEYPIQRSKKDSEGIEMGVAGSVSLLQNVTL-STQPISSLDWSPDKRGLCV 338 Query: 444 CS 445 CS Sbjct: 339 CS 340 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6J6H-n nrPDB 624 e-179 5YZG-W nrPDB 415 e-116 6QDV-o nrPDB 415 e-116 3JB9-g nrPDB 410 e-115 6QX9-5O nrPDB 259 2e-69 5M25-A nrPDB 258 3e-69 2H9P-A nrPDB 251 6e-67 5MZH-A nrPDB 233 1e-61 5NNZ-B nrPDB 233 1e-61 6F3T-A nrPDB 224 6e-59 5OPT-p nrPDB 218 3e-57 6G51-g nrPDB 216 2e-56 3JB9-L nrPDB 214 6e-56 6HQA-B nrPDB 208 5e-54 4V6W-Ag nrPDB 206 2e-53 5WLC-LO nrPDB 204 5e-53 6HHQ-h nrPDB 203 9e-53 5I2T-A nrPDB 202 2e-52 1VYH-C nrPDB 201 7e-52 6MZM-G nrPDB 197 7e-51 3DM0-A nrPDB 197 9e-51 3JAP-g nrPDB 195 4e-50 5FL8-q nrPDB 194 9e-50 3MKQ-A nrPDB 191 4e-49 5XYI-g nrPDB 190 8e-49 2YNP-A nrPDB 188 4e-48 6ID0-T nrPDB 184 7e-47 5NZU-C nrPDB 183 1e-46 6QX9-4B nrPDB 180 1e-45 4V8M-A7 nrPDB 176 1e-44 5Y88-O nrPDB 171 5e-43 5Z56-q nrPDB 168 6e-42 4V7E-Bg nrPDB 167 9e-42 5G04-R nrPDB 166 1e-41 5OQL-d nrPDB 166 2e-41 5WBU-D nrPDB 166 2e-41 3FM0-A nrPDB 165 3e-41 4GGA-A nrPDB 164 7e-41 4BTS-AR nrPDB 164 7e-41 5GAN-H nrPDB 163 1e-40 4LG8-A nrPDB 162 3e-40 3JZG-A nrPDB 161 6e-40 5UZ7-B nrPDB 159 2e-39 6N9G-C nrPDB 158 5e-39 6Q8F-A nrPDB 158 5e-39 6EMK-B nrPDB 157 1e-38 5FVM-C nrPDB 155 3e-38 6E29-D nrPDB 154 7e-38 6GMH-W nrPDB 153 2e-37 5OV3-A nrPDB 151 5e-37 6BX3-A nrPDB 147 9e-36 5LCW-Q nrPDB 146 2e-35 5WYJ-BC nrPDB 145 3e-35 6CHG-A nrPDB 145 4e-35 1NR0-A nrPDB 143 1e-34 4N14-A nrPDB 142 2e-34 2HES-X nrPDB 141 4e-34 5K1B-B nrPDB 141 8e-34 3C9C-A nrPDB 138 6e-33 5OQL-L nrPDB 137 1e-32 4XFV-A nrPDB 137 1e-32 6EOJ-D nrPDB 137 1e-32 3ODT-A nrPDB 135 3e-32 5Y1U-A nrPDB 135 4e-32 3CFV-B nrPDB 134 1e-31 5MWJ-A nrPDB 134 1e-31 4A11-B nrPDB 130 1e-30 5WYK-BB nrPDB 129 2e-30 5WJC-A nrPDB 125 5e-29 4AEZ-A nrPDB 123 2e-28 5FA5-B nrPDB 123 2e-28 5L9T-R nrPDB 121 7e-28 5K0Y-T nrPDB 120 1e-27 6ELZ-p nrPDB 120 1e-27 5OQL-J nrPDB 118 4e-27 4XYI-A nrPDB 113 2e-25 5A31-R nrPDB 112 3e-25 4BH6-A nrPDB 110 1e-24 5OQL-X nrPDB 108 5e-24 4OWR-A nrPDB 105 5e-23 5BJS-A nrPDB 98 7e-21 3ACP-A nrPDB 96 2e-20 4G56-B nrPDB 92 4e-19 Sequences not found previously or not previously below threshold: 4YCZ-A nrPDB 132 4e-31 3JRO-A nrPDB 128 5e-30 5WLC-LU nrPDB 126 2e-29 4L9O-A nrPDB 124 6e-29 4J0W-A nrPDB 124 1e-28 3JRP-A nrPDB 121 6e-28 4BZK-B nrPDB 119 4e-27 2AQ5-A nrPDB 111 7e-25 5CXC-A nrPDB 111 9e-25 5WYJ-BE nrPDB 110 1e-24 3BG0-A nrPDB 109 3e-24 5N4A-A nrPDB 106 2e-23 5WLC-LJ nrPDB 103 1e-22 4E5Z-B nrPDB 102 4e-22 4U1E-I nrPDB 102 4e-22 4PSX-B nrPDB 101 7e-22 6EM1-m nrPDB 99 3e-21 3W15-A nrPDB 98 6e-21 6BX3-B nrPDB 96 4e-20 6CB1-s nrPDB 93 2e-19 6CHG-D nrPDB 93 3e-19 6C0F-s nrPDB 92 5e-19 5YZG-2 nrPDB 91 9e-19 2PM9-A nrPDB 91 9e-19 5M89-A nrPDB 90 2e-18 3F3P-A nrPDB 86 3e-17 2P9P-C nrPDB 86 3e-17 1PI6-A nrPDB 85 5e-17 6F1U-h nrPDB 85 5e-17 5CXB-B nrPDB 84 1e-16 5WLC-LN nrPDB 82 5e-16 5A9Q-2 nrPDB 80 2e-15 4J0X-A nrPDB 79 5e-15 5WLC-SG nrPDB 78 1e-14 5A9Q-0 nrPDB 77 1e-14 5A9Q-7 nrPDB 76 3e-14 3EI3-B nrPDB 76 4e-14 5WLC-LW nrPDB 74 1e-13 3DWL-C nrPDB 73 2e-13 5K19-A nrPDB 73 4e-13 3I2N-A nrPDB 72 5e-13 3JB9-S nrPDB 68 9e-12 5MC6-j nrPDB 65 6e-11 5WLC-LS nrPDB 64 1e-10 5AJA-A nrPDB 64 1e-10 2I3T-A nrPDB 63 2e-10 3DW8-B nrPDB 59 3e-09 6CVZ-A nrPDB 59 4e-09 5TF2-A nrPDB 59 5e-09 4FHN-A nrPDB 58 6e-09 5AMS-A nrPDB 58 1e-08 6IYY-A nrPDB 56 3e-08 5LTD-A nrPDB 52 4e-07 2VDU-B nrPDB 51 1e-06 5WLC-LH nrPDB 51 1e-06 6N8P-A nrPDB 46 3e-05 4AV8-A nrPDB 46 3e-05 5K1H-B nrPDB 43 2e-04 5WLC-LV nrPDB 43 3e-04 4YHC-A nrPDB 41 0.001 5WLC-LL nrPDB 41 0.002 5GRS-A nrPDB 39 0.004 4NOX-A nrPDB 39 0.006 6NAU-A nrPDB 38 0.007 6IGB-A nrPDB 36 0.039 5CWW-B nrPDB 35 0.058 2EEP-A nrPDB 34 0.10 5BPT-A nrPDB 34 0.11 5OLJ-A nrPDB 34 0.18 6FYY-p nrPDB 34 0.20 5BPW-A nrPDB 33 0.29 4U1F-A nrPDB 33 0.33 5XJC-J nrPDB 33 0.35 6AHD-X nrPDB 32 0.36 3AZQ-A nrPDB 32 0.39 6G18-v nrPDB 31 0.89 5ZC2-B nrPDB 31 1.1 5SUM-A nrPDB 31 1.2 6IRA-D nrPDB 31 1.2 5TXC-A nrPDB 31 1.6 2QT9-A nrPDB 31 1.6 1LL6-A nrPDB 31 1.6 1K3I-A nrPDB 30 1.7 3R3L-A nrPDB 30 2.1 3MWP-A nrPDB 30 2.1 5A31-O nrPDB 30 2.2 4DYK-A nrPDB 30 2.7 5JN2-A nrPDB 30 2.8 3MA6-A nrPDB 30 2.8 5HAX-A nrPDB 29 3.1 3OQJ-A nrPDB 29 3.6 1Q0Y-L nrPDB 29 6.2 1ZXN-A nrPDB 28 7.4 1JN6-A nrPDB 28 8.0 >6J6H-n nrPDB Length = 455 Score = 624 bits (1610), Expect = e-179, Method: Composition-based stats. Identities = 455/455 (100%), Positives = 455/455 (100%) Query: 1 MGLVDGYDTSSDSDLNFDEGKSVHEKKNGNLHEDTSYEPSSNNIHKRKSHFTKSELKRRR 60 MGLVDGYDTSSDSDLNFDEGKSVHEKKNGNLHEDTSYEPSSNNIHKRKSHFTKSELKRRR Sbjct: 1 MGLVDGYDTSSDSDLNFDEGKSVHEKKNGNLHEDTSYEPSSNNIHKRKSHFTKSELKRRR 60 Query: 61 KTRKGDGPWGSWSSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSE 120 KTRKGDGPWGSWSSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSE Sbjct: 61 KTRKGDGPWGSWSSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSE 120 Query: 121 KDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILS 180 KDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILS Sbjct: 121 KDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILS 180 Query: 181 GGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKV 240 GGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKV Sbjct: 181 GGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKV 240 Query: 241 KTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALK 300 KTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALK Sbjct: 241 KTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALK 300 Query: 301 YFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRI 360 YFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRI Sbjct: 301 YFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRI 360 Query: 361 YSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNN 420 YSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNN Sbjct: 361 YSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNN 420 Query: 421 IKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 IKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD Sbjct: 421 IKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 >5YZG-W nrPDB Length = 579 Score = 415 bits (1066), Expect = e-116, Method: Composition-based stats. Identities = 149/391 (38%), Positives = 221/391 (56%), Gaps = 7/391 (1%) Query: 67 GPWGSWSSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGR 126 GPW + D + E QKE +I + + E+ EE + + K DYQGR Sbjct: 194 GPWAKYVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEK-PGEEKTILHVKEMYDYQGR 252 Query: 127 GYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHT 186 YL+ P DV V+LR +CYLPKK I + GH +G +A++ P +GHL+LS D Sbjct: 253 SYLHIPQDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCK 312 Query: 187 IKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHL 246 IK+W+ Y + CLR F GH+K ++ + F FLS+++DR +K+WDTETG+ +R Sbjct: 313 IKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTN 372 Query: 247 NSTPADVESRPTNPHE--FIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPD 304 P V+ P + F+ G+S+ KI+ +D R E +VQ YD HL ++ + + + Sbjct: 373 RKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGE---IVQEYDRHLGAVNTIVFVDE 429 Query: 305 GSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFS 364 +F+S+S+DK++R+WE I V K I++ + HSMP + + P+ + QSMDN+I F Sbjct: 430 NRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFG 489 Query: 365 LKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIP 424 + +++ + KKIFKGH AGY + FS D Y+ SGD +L WDW T++L + K Sbjct: 490 AQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAH 549 Query: 425 GNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 I V WHP ETSKVI G G I + D Sbjct: 550 DKVCIGAV-WHPHETSKVITCGWDGLIKLWD 579 >6QDV-o nrPDB Length = 513 Score = 415 bits (1066), Expect = e-116, Method: Composition-based stats. Identities = 149/391 (38%), Positives = 221/391 (56%), Gaps = 7/391 (1%) Query: 67 GPWGSWSSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGR 126 GPW + D + E QKE +I + + E+ EE + + K DYQGR Sbjct: 128 GPWAKYVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEK-PGEEKTILHVKEMYDYQGR 186 Query: 127 GYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHT 186 YL+ P DV V+LR +CYLPKK I + GH +G +A++ P +GHL+LS D Sbjct: 187 SYLHIPQDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCK 246 Query: 187 IKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHL 246 IK+W+ Y + CLR F GH+K ++ + F FLS+++DR +K+WDTETG+ +R Sbjct: 247 IKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTN 306 Query: 247 NSTPADVESRPTNPHE--FIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPD 304 P V+ P + F+ G+S+ KI+ +D R E +VQ YD HL ++ + + + Sbjct: 307 RKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGE---IVQEYDRHLGAVNTIVFVDE 363 Query: 305 GSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFS 364 +F+S+S+DK++R+WE I V K I++ + HSMP + + P+ + QSMDN+I F Sbjct: 364 NRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFG 423 Query: 365 LKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIP 424 + +++ + KKIFKGH AGY + FS D Y+ SGD +L WDW T++L + K Sbjct: 424 AQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAH 483 Query: 425 GNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 I V WHP ETSKVI G G I + D Sbjct: 484 DKVCIGAV-WHPHETSKVITCGWDGLIKLWD 513 >3JB9-g nrPDB Length = 558 Score = 410 bits (1054), Expect = e-115, Method: Composition-based stats. Identities = 170/448 (37%), Positives = 256/448 (57%), Gaps = 39/448 (8%) Query: 38 EPSSNNIHKRKSHFTKSELKRRRK------TRKGDGPW-GSWSSSDDETSQASETQ---- 86 E +++ KRKS ++K RR+ +GDG + G W+ E S + Sbjct: 120 EATTSTDLKRKSQ----KIKERREDPGDPSILEGDGAYKGPWAGYGSEQSSSPLEYSEYE 175 Query: 87 -------KEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEK--------DYQGRGYLYP 131 K ++D + L ++ L EQ+ EV K E DYQ R Y++ Sbjct: 176 EVESLDVKSEKDTESNNLGQNELLKEQLATPEVETHRSKEETILHKDRLFDYQNRSYMHV 235 Query: 132 PNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWD 191 PNDV ++L EE CY+PKK I + GH +G + L+F P +GHL+LSG D+ IKIW+ Sbjct: 236 PNDVGINLSEEPGEQTCYIPKKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWE 295 Query: 192 FYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPA 251 YHD LR FQGH +PI+ L F++D +SFLS+SFD+++K+WDTE GK + + Sbjct: 296 VYHDRSLLRTFQGHARPIRDLSFSQDGRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLTN 355 Query: 252 DVESR--PTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFI 309 V+ + P P+EF+ G ++ +IL +D R + +VQ YDHHL I ++ + +G +F+ Sbjct: 356 CVKFQVDPDKPNEFLAGTADKRILQFDIR---SPDIVQAYDHHLGGINSITFLENGKRFV 412 Query: 310 SSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKY 369 ++S+D ++R WE VPIK ++D A HSMP + + P+ QS+DN IY +S KY Sbjct: 413 TTSDDSSMRFWEYGTPVPIKFVADIAMHSMPRVALRPNGKSIACQSLDNCIYVYSAYEKY 472 Query: 370 KRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNK-P 428 +++ KK+FKG+S +GY + + FS DGR++ SGDS WDW T +L+ K+P + P Sbjct: 473 RQNKKKVFKGYSCSGYSLEVGFSPDGRFVFSGDSSGNACFWDWKTCKLMA--KLPAHSGP 530 Query: 429 ITQVDWHPQETSKVICSG-AAGKIYVCD 455 + + +HPQETSKV S G I D Sbjct: 531 VQSMAFHPQETSKVATSSIVDGSIKYWD 558 >6QX9-5O nrPDB Length = 357 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 75/321 (23%), Positives = 138/321 (42%), Gaps = 13/321 (4%) Query: 133 NDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF 192 + RC + I GH KF P G + S G D I +W+ Sbjct: 37 QQATPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHP-NGSTLASAGFDRLILLWNV 95 Query: 193 YHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPAD 252 Y D + +GH+ + L + D S+S D++V +WD+ETG+ RL +++ + Sbjct: 96 YGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVN 155 Query: 253 VESRP-TNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISS 311 P G + + +D R + +QT+ + +LA+ + + IS Sbjct: 156 SCYPARRGPQLVCTGSDDGTVKLWDIR---KKAAIQTFQN-TYQVLAVTFNDTSDQIISG 211 Query: 312 SEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKP-KYK 370 D +++W+ + N + S+ L++ +Y + +MDN + + ++P K Sbjct: 212 GIDNDIKVWDLRQNKLTYTM-RGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPK 270 Query: 371 RHPKKIFKG--HSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNK- 427 KIF+G H+ + ++S DG I +G + ++ WD + R+L K+PG+ Sbjct: 271 ERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRIL--YKLPGHAG 328 Query: 428 PITQVDWHPQETSKVICSGAA 448 I +V +HP E + S Sbjct: 329 SINEVAFHPDEPIIISASSDK 349 Score = 115 bits (287), Expect = 5e-26, Method: Composition-based stats. Identities = 42/221 (19%), Positives = 85/221 (38%), Gaps = 21/221 (9%) Query: 109 VEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKK--VIRNYPGHPEGTT 166 V+ + Y R P V + + + + +K I+ + + Sbjct: 144 VKRLKGHTSFVNSCYPARR---GPQLVCTGSDD--GTVKLWDIRKKAAIQTFQ-NTYQVL 197 Query: 167 ALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSF 226 A+ F T I+SGG D+ IK+WD + + +GH + L + + LS++ Sbjct: 198 AVTFN-DTSDQIISGGIDNDIKVWDLRQN-KLTYTMRGHADSVTGLSLSSEGSYLLSNAM 255 Query: 227 DRSVKIWDTE----TGKVKTRLHLNSTPADV----ESRPTNPHEFIVGLSNSKILHYDDR 278 D +V++WD + N + S + + G ++ + +D Sbjct: 256 DNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWD-- 313 Query: 279 VSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRI 319 + ++ ++ H SI + + PD IS+S DK + + Sbjct: 314 -TTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYM 353 >5M25-A nrPDB Length = 434 Score = 258 bits (660), Expect = 3e-69, Method: Composition-based stats. Identities = 79/371 (21%), Positives = 148/371 (39%), Gaps = 20/371 (5%) Query: 91 DIFVHALAEDNLDSEQIEVEEVSHFYGKSEKD--YQGRGYLYPPNDVDVDLREERISFRC 148 + F + +DS + + + ++ +D + + + + Sbjct: 73 EAFAKRQGK-EMDSLRFLYDGIRIQADQTPEDLDMEDNDIIEAHREQIGGSATQSKPTPV 131 Query: 149 YLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKP 208 + GH + +++KF P G + S D IKIW Y D + + GH Sbjct: 132 KPNYALKFTLAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAY-DGKFEKTISGHKLG 189 Query: 209 IKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLS 268 I + ++ D +S+S D+++KIWD +GK L +S + + + G Sbjct: 190 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 249 Query: 269 NSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPI 328 + + +D + ++T H + A+ + DGS +SSS D RIW+ + Sbjct: 250 DESVRIWDVKTG---KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL 306 Query: 329 KQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGIS 388 K + D + F+ P+ Y A ++DN + + K K + GH + Y I Sbjct: 307 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD---YSKGKCLKTYTGHKNEKYCIF 363 Query: 389 LAFS-GDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPIT-QVDWHPQETSKVICSG 446 FS G++I SG + ++ W+ T ++ K+ G+ + HP E +I S Sbjct: 364 ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ--KLQGHTDVVISTACHPTEN--IIASA 419 Query: 447 A---AGKIYVC 454 A I + Sbjct: 420 ALENDKTIKLW 430 Score = 126 bits (315), Expect = 3e-29, Method: Composition-based stats. Identities = 37/168 (22%), Positives = 68/168 (40%), Gaps = 8/168 (4%) Query: 288 TYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPS 347 T H ++ ++K+ P+G SSS DK ++IW K IS + + + Sbjct: 140 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS-GHKLGISDVAWSSD 198 Query: 348 QNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRL 407 N + S D + + + K KGHS+ + F+ I SG + Sbjct: 199 SNLLVSASDDKTLKIWDV---SSGKCLKTLKGHSNYVFC--CNFNPQSNLIVSGSFDESV 253 Query: 408 FTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 WD T + L + + P++ V ++ ++ S ++ S G + D Sbjct: 254 RIWDVKTGKCLKTLPAH-SDPVSAVHFN-RDGSLIVSSSYDGLCRIWD 299 Score = 42.9 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 15/83 (18%), Positives = 30/83 (36%), Gaps = 10/83 (12%) Query: 118 KSEKDYQGRGYLYPPN-------DVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKF 170 K+ ++ Y N + + + K++++ GH + + Sbjct: 350 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTAC 409 Query: 171 LPKTGHLILSGG--NDHTIKIWD 191 P ++I S ND TIK+W Sbjct: 410 HPTE-NIIASAALENDKTIKLWK 431 >2H9P-A nrPDB Length = 329 Score = 251 bits (640), Expect = 6e-67, Method: Composition-based stats. Identities = 75/303 (24%), Positives = 130/303 (42%), Gaps = 17/303 (5%) Query: 157 NYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTE 216 GH + +++KF P G + S D IKIW Y D + + GH I + ++ Sbjct: 35 TLAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAY-DGKFEKTISGHKLGISDVAWSS 92 Query: 217 DCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYD 276 D +S+S D+++KIWD +GK L +S + + + G + + +D Sbjct: 93 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 152 Query: 277 DRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQ 336 + ++T H + A+ + DGS +SSS D RIW+ +K + D Sbjct: 153 VKTG---KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 209 Query: 337 HSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFS-GDG 395 + F+ P+ Y A ++DN + + K K + GH + Y I FS G Sbjct: 210 PPVSFVKFSPNGKYILAATLDNTLKLWD---YSKGKCLKTYTGHKNEKYCIFANFSVTGG 266 Query: 396 RYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPIT-QVDWHPQETSKVICSGA---AGKI 451 ++I SG + ++ W+ T ++ K+ G+ + HP E +I S A I Sbjct: 267 KWIVSGSEDNLVYIWNLQTKEIVQ--KLQGHTDVVISTACHPTEN--IIASAALENDKTI 322 Query: 452 YVC 454 + Sbjct: 323 KLW 325 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 53/280 (18%), Positives = 111/280 (39%), Gaps = 9/280 (3%) Query: 133 NDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF 192 + ++ I K + GH G + + + + +L++S +D T+KIWD Sbjct: 53 EWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS-NLLVSASDDKTLKIWDV 111 Query: 193 YHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPAD 252 +CL+ +GH+ + F +S SFD SV+IWD +TGK L +S P Sbjct: 112 SSG-KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVS 170 Query: 253 VESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSS 312 + + + +D + + D + +K+ P+G ++++ Sbjct: 171 AVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL--IDDDNPPVSFVKFSPNGKYILAAT 228 Query: 313 EDKTVRIWENQINVPIKQISDTAQHSMP-FLNVHPS-QNYFCAQSMDNRIYSFSLKPKYK 370 D T+++W+ +K + F N + + + S DN +Y ++L+ K Sbjct: 229 LDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI 288 Query: 371 RHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTW 410 + GH+ + + + + ++ + W Sbjct: 289 VQKLQ---GHTDVVISTACHPTENIIASAALENDKTIKLW 325 Score = 41.7 bits (96), Expect = 7e-04, Method: Composition-based stats. Identities = 15/83 (18%), Positives = 30/83 (36%), Gaps = 10/83 (12%) Query: 118 KSEKDYQGRGYLYPPN-------DVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKF 170 K+ ++ Y N + + + K++++ GH + + Sbjct: 245 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTAC 304 Query: 171 LPKTGHLILSGG--NDHTIKIWD 191 P ++I S ND TIK+W Sbjct: 305 HPTE-NIIASAALENDKTIKLWK 326 >5MZH-A nrPDB Length = 452 Score = 233 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 61/338 (18%), Positives = 114/338 (33%), Gaps = 21/338 (6%) Query: 126 RGYLYPPNDVDVDLREERISFRCYL---------PKKVIRNYPGHPEGTTALKFLPKTGH 176 R ++ P + + +R Y + + GH A+ F G Sbjct: 91 RAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVYAIAFNNPYGD 150 Query: 177 LILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTE 236 I++G D T K+WD Y + +GH I L F + S D + K+WD E Sbjct: 151 KIVTGSFDKTCKLWDAYTG-QLYYTLKGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVE 209 Query: 237 TGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSI 296 TG+ + L + T + G + +D R + V H + Sbjct: 210 TGQERATLAGHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQ---CVHVLSGHRGEV 266 Query: 297 LALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSM 356 + ++ G+ +S S D T R+W+ + + + + + + + S Sbjct: 267 SSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCL-SVKQGHTDEVLDVAFDAAGTKMVSASA 325 Query: 357 DNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSR 416 D + +H GH G +AF+ G + + S WD +T Sbjct: 326 DGSARLYHTLTGVCQH---TLVGH--EGEISKVAFNPQGTRLITASSDKTCRLWDCDTGE 380 Query: 417 LLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVC 454 L ++ ++ I ++ E +I + Sbjct: 381 CLQVLEGHTDE-IFSCAFN-YEGDFIITGSKDNTCRIW 416 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 46/263 (17%), Positives = 100/263 (38%), Gaps = 12/263 (4%) Query: 193 YHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPAD 252 +H + + + H P+ F + F++ S+DR+ K+W+T TG+ L + Sbjct: 81 HHSFTLFKVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTLEGHKNVVY 140 Query: 253 -VESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISS 311 + + + G + +D + L T H + I+ L + P + + Sbjct: 141 AIAFNNPYGDKIVTGSFDKTCKLWDAYTGQ---LYYTLKGHQTEIVCLSFNPQSTIIATG 197 Query: 312 SEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKR 371 S D T ++W+ + ++ + + L + + S D+ + ++ Sbjct: 198 SMDNTAKLWDVETGQERATLA-GHRAEIVSLGFNTGGDLIVTGSFDHDSRLWDVRTGQCV 256 Query: 372 HPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQ 431 H + GH G S F+ G + SG WD + R L+ + ++ + Sbjct: 257 H---VLSGH--RGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQGHTDE-VLD 310 Query: 432 VDWHPQETSKVICSGAAGKIYVC 454 V + +K++ + A G + Sbjct: 311 VAFDA-AGTKMVSASADGSARLY 332 Score = 112 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 27/172 (15%), Positives = 58/172 (33%), Gaps = 7/172 (4%) Query: 112 VSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFL 171 H S + G L +D R + + + GH + + F Sbjct: 260 SGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVR-----SGRCLSVKQGHTDEVLDVAFD 314 Query: 172 PKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVK 231 G ++S D + +++ C GH I + F +++S D++ + Sbjct: 315 AA-GTKMVSASADGSARLYHTLTGV-CQHTLVGHEGEISKVAFNPQGTRLITASSDKTCR 372 Query: 232 IWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQ 283 +WD +TG+ L ++ + I G ++ + + +Q Sbjct: 373 LWDCDTGECLQVLEGHTDEIFSCAFNYEGDFIITGSKDNTCRIWKALTASSQ 424 >5NNZ-B nrPDB Length = 415 Score = 233 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 69/390 (17%), Positives = 139/390 (35%), Gaps = 23/390 (5%) Query: 75 SDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQG-RGYLYPPN 133 S D ++ E QK + + + L ++++ E++ + ++ + ++ P Sbjct: 38 STDVSALVEEIQKAEPLLTASRTEQVKLLIQRLQ-EKLGQNSNHTFYLFKVLKAHILPLT 96 Query: 134 DVDVDLR-------EERISFRCYL--PKKVIRNYPGHPEGTTALKFLPKTGHLILSGGND 184 +V ++ + + + + + GH A+ F G I +G D Sbjct: 97 NVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFD 156 Query: 185 HTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRL 244 T K+W +C F+GH I L F + S D + K+WD + G+ L Sbjct: 157 KTCKLWSVETG-KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTL 215 Query: 245 HLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPD 304 +S S T+ I G + ++ +D V H + I + + D Sbjct: 216 RGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRK---VNILIGHCAEISSASFNWD 272 Query: 305 GSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFS 364 S ++ S DKT ++W+ + + + + S D FS Sbjct: 273 CSLILTGSMDKTCKLWDATNGKCVATL-TGHDDEILDSCFDYTGKLIATASADGTARIFS 331 Query: 365 LKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIP 424 + K I K G ++F+ G ++ +G S WD T + L ++ Sbjct: 332 AATR-----KCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGH 386 Query: 425 GNKPITQVDWHPQETSKVICSGAAGKIYVC 454 ++ I ++ + + VI + Sbjct: 387 TDE-IFSCAFNYK-GNIVITGSKDNTCRIW 414 Score = 147 bits (370), Expect = 1e-35, Method: Composition-based stats. Identities = 56/321 (17%), Positives = 107/321 (33%), Gaps = 30/321 (9%) Query: 7 YDTSSDSDLNFDEGKSVHEKKNGNLHEDTSYEPSSNNIHKRKSHFTKSELKRRRKTRKGD 66 +DT+S +LN EG H + Y + NN + K + + + + Sbjct: 119 WDTASGEELNTLEG-----------HRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETG 167 Query: 67 GPWGSWSSSDDE------TSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSE 120 + ++ E Q++ D N + + S Sbjct: 168 KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSF 227 Query: 121 KDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILS 180 R + + + + + GH ++ F LIL+ Sbjct: 228 NTSGDR--------IITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDC-SLILT 278 Query: 181 GGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKV 240 G D T K+WD + +C+ GH+ I F + ++S D + +I+ T K Sbjct: 279 GSMDKTCKLWD-ATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKC 337 Query: 241 KTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALK 300 +L + S + + G S+ +D + + +Q + H I + Sbjct: 338 IAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQ---CLQVLEGHTDEIFSCA 394 Query: 301 YFPDGSKFISSSEDKTVRIWE 321 + G+ I+ S+D T RIW Sbjct: 395 FNYKGNIVITGSKDNTCRIWR 415 >6F3T-A nrPDB Length = 608 Score = 224 bits (571), Expect = 6e-59, Method: Composition-based stats. Identities = 60/245 (24%), Positives = 99/245 (40%), Gaps = 15/245 (6%) Query: 78 ETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDV 137 + S S KE D+ + E +I YG S R YL ++ D Sbjct: 317 QASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSP--DRNYLLSSSE-DG 373 Query: 138 DLREERI-SFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDY 196 +R + +F C + Y GH +F P G+ +SGG+D ++W Y Sbjct: 374 TVRLWSLQTFTC------LVGYKGHNYPVWDTQFSPY-GYYFVSGGHDRVARLW-ATDHY 425 Query: 197 ECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESR 256 + LR F GH + RF + + S DR+V++WD G + P + Sbjct: 426 QPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTF 485 Query: 257 PTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKT 316 N G ++ ++L +D + +V H ++ +L++ DG S S D T Sbjct: 486 SPNGRFLATGATDGRVLLWDI---GHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNT 542 Query: 317 VRIWE 321 VR+W+ Sbjct: 543 VRLWD 547 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 58/312 (18%), Positives = 112/312 (35%), Gaps = 43/312 (13%) Query: 134 DVDVDLREERISFRCY---LPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIW 190 D ++++E R LP + +G TA+ LI G D T+++W Sbjct: 247 DKIMNMKETTKRVRLGPDCLPSICFYTFLNAYQGLTAVDVT-DDSSLIAGGFADSTVRVW 305 Query: 191 DFY------------------------------HDYECLRDFQGHNKPIKALRFTEDCQS 220 L+ GH+ P+ F+ D Sbjct: 306 SVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNY 365 Query: 221 FLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVS 280 LSSS D +V++W +T ++ P + F+ G + + + Sbjct: 366 LLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLW---AT 422 Query: 281 ENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMP 340 ++ ++ + HL+ + ++ P+ + + S D+TVR+W+ ++ I + + Sbjct: 423 DHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVR-IFTGHKGPIH 481 Query: 341 FLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICS 400 L P+ + + D R+ + + KGH+ SL FS DG + S Sbjct: 482 SLTFSPNGRFLATGATDGRVLLWDIG---HGLMVGELKGHTDTV--CSLRFSRDGEILAS 536 Query: 401 GDSKSRLFTWDW 412 G + + WD Sbjct: 537 GSMDNTVRLWDA 548 >5OPT-p nrPDB Length = 318 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 60/311 (19%), Positives = 124/311 (39%), Gaps = 18/311 (5%) Query: 107 IEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTT 166 + +++ Y K+ + + +++D + E F R GH + Sbjct: 19 LACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPE-------RRLEGHSAFVS 71 Query: 167 ALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSF 226 + L G +S DH++++W+ C F GH K + ++ F+ D + +S Sbjct: 72 DVA-LSNNGDFAVSASWDHSLRLWNLQTGV-CQHKFLGHTKDVLSVTFSPDNRQIVSGGR 129 Query: 227 DRSVKIWDTETGKVKT--RLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQG 284 D ++++W+ + + T R + V P+ IV ++ D S Sbjct: 130 DNALRVWNVKGECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASG--R 187 Query: 285 LVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNV 344 L+ H + I ++ PDGS SS +D R+W+ + +++ A + + Sbjct: 188 LLTDLKGHTNYITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGA--PINQICF 245 Query: 345 HPSQNYFCAQSMDNRIYSFSLKPKYKRHPK--KIFKGHSSAGYGISLAFSGDGRYICSGD 402 P++ + CA + I F L+ K + + +S+A+S DG + SG Sbjct: 246 SPNRYWMCAATEKG-IRIFDLENKDVIVELAPEAQQKSKKTPECMSIAWSADGNTLYSGY 304 Query: 403 SKSRLFTWDWN 413 + + + W + Sbjct: 305 TDNVIRVWSVS 315 Score = 144 bits (362), Expect = 9e-35, Method: Composition-based stats. Identities = 48/270 (17%), Positives = 92/270 (34%), Gaps = 28/270 (10%) Query: 201 DFQGHNKPIKALR---FTEDCQSFLSSSFDRSVKIW---------DTETGKVKTRLHLNS 248 +GH + AL TE +S+S D ++ W + E G + RL +S Sbjct: 8 QLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHS 67 Query: 249 TPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKF 308 + N + + + ++ + + H +L++ + PD + Sbjct: 68 AFVSDVALSNNGDFAVSASWDHSLRLWNLQTG---VCQHKFLGHTKDVLSVTFSPDNRQI 124 Query: 309 ISSSEDKTVRIWENQINVPIKQISDT-AQHSMPFLNVHPS--QNYFCAQSMDNRIYSFSL 365 +S D +R+W + + + + + PS + DN + + + Sbjct: 125 VSGGRDNALRVWNVK-GECLHTLGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDI 183 Query: 366 KPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPG 425 KGH++ Y S+ S DG S D WD L+ + Sbjct: 184 A---SGRLLTDLKGHTN--YITSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEM--AA 236 Query: 426 NKPITQVDWHPQETSKVICSGAAGKIYVCD 455 PI Q+ + P +C+ I + D Sbjct: 237 GAPINQICFSPN--RYWMCAATEKGIRIFD 264 >6G51-g nrPDB Length = 317 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 58/274 (21%), Positives = 110/274 (40%), Gaps = 18/274 (6%) Query: 150 LPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPI 209 +P++ +R GH + + G LSG D T+++WD R F GH K + Sbjct: 54 IPQRALR---GHSHFVSDVVISSD-GQFALSGSWDGTLRLWDLTTG-TTTRRFVGHTKDV 108 Query: 210 KALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLH---LNSTPADVESRPTNPHEFIVG 266 ++ F+ D + +S S D+++K+W+T G K + + + V P + + IV Sbjct: 109 LSVAFSSDNRQIVSGSRDKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVS 167 Query: 267 LSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINV 326 K++ + N L + H + + PDGS S +D +W+ Sbjct: 168 CGWDKLVKVWNLA--NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK 225 Query: 327 PIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKK----IFKGHSS 382 + + + L P++ + CA + + I + L+ K K + Sbjct: 226 HLYTL--DGGDIINALCFSPNRYWLCAATGPS-IKIWDLEGKIIVDELKQEVISTSSKAE 282 Query: 383 AGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSR 416 SLA+S DG+ + +G + + + W Sbjct: 283 PPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316 >3JB9-L nrPDB Length = 340 Score = 214 bits (545), Expect = 6e-56, Method: Composition-based stats. Identities = 61/292 (20%), Positives = 122/292 (41%), Gaps = 12/292 (4%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQ 219 GH +F P +G SGG D I +W+ + D + G I L+++ D + Sbjct: 48 GHTAEVLVARFDP-SGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQWSRDSR 106 Query: 220 SFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRV 279 SS D + WD +G+ + ++ + E + +S+ + D Sbjct: 107 VVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWD-- 164 Query: 280 SENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSM 339 S ++ ++T + + A+ G++ D ++IW+ + N + + + Sbjct: 165 SRSKDCIKTIEE-KYPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNN-HCSHVLKGHKDII 222 Query: 340 PFLNVHPSQNYFCAQSMDNRIYSFSLKP-KYKRHPKKIFKG--HSSAGYGISLAFSGDGR 396 L + + + SMDN + F +KP + +IF+G H + +A+S + R Sbjct: 223 TSLAISKDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNSR 282 Query: 397 YICSGDSKSRLFTWDWNTSRLLNNIKIPGNK-PITQVDWHPQETSKVICSGA 447 ++ +G S ++ W T L +PG++ + VD+HP + + CS Sbjct: 283 FVGAGSSDKNVYVWSA-TGDL--RYVLPGHEGSVNHVDFHPHQDIILSCSSD 331 Score = 125 bits (313), Expect = 5e-29, Method: Composition-based stats. Identities = 40/228 (17%), Positives = 88/228 (38%), Gaps = 9/228 (3%) Query: 138 DLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYE 197 + + + + IR + GH AL L L+ S +D T+K+WD + Sbjct: 111 SSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWD-SRSKD 169 Query: 198 CLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRP 257 C++ + P+ A+ + D ++KIWD L + + Sbjct: 170 CIKTIEE-KYPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCSHVLKGHKDIITSLAIS 228 Query: 258 TNPHEFIVGLSNSKILHYDDR-VSENQGLVQTYDH--H--LSSILALKYFPDGSKFISSS 312 + + ++ + +D + + Q +Q ++ H ++L + + + + S Sbjct: 229 KDGSSLLSNSMDNTVRIFDVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGS 288 Query: 313 EDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRI 360 DK V +W + ++ + + S+ ++ HP Q+ + S D I Sbjct: 289 SDKNVYVWSATGD--LRYVLPGHEGSVNHVDFHPHQDIILSCSSDRTI 334 Score = 57.9 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 13/75 (17%), Positives = 26/75 (34%), Gaps = 3/75 (4%) Query: 158 YPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTED 217 G + + + + +G +D + +W D GH + + F Sbjct: 265 IHGQEHNLLGVAWS-RNSRFVGAGSSDKNVYVWSATGDLR--YVLPGHEGSVNHVDFHPH 321 Query: 218 CQSFLSSSFDRSVKI 232 LS S DR++ + Sbjct: 322 QDIILSCSSDRTIFL 336 >6HQA-B nrPDB Length = 722 Score = 208 bits (528), Expect = 5e-54, Method: Composition-based stats. Identities = 58/279 (20%), Positives = 108/279 (38%), Gaps = 31/279 (11%) Query: 198 CLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKT--------------- 242 C+ F N + L+F +D S D +K+W + +++ Sbjct: 382 CMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDGV 441 Query: 243 ------RLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSI 296 RL +S + I + + + + +Y H SS+ Sbjct: 442 AVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTY---TCLVSYKGHSSSV 498 Query: 297 LALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSM 356 +K+ P G F ++S D+T R+W P++ I + + + HP+ Y S Sbjct: 499 WDVKFSPMGHYFATASHDQTARLWSCDHIYPLR-IFAGHLNDVDCVEFHPNSTYLFTGSS 557 Query: 357 DNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSR 416 D + + + ++F GHS A LA S DGR++ S S + WD +T R Sbjct: 558 DKTARMWDIA---RGECVRVFMGHSGAINC--LAVSPDGRWLASAGEDSVVCLWDISTGR 612 Query: 417 LLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 + ++ G I + + +E + ++ +GA + V D Sbjct: 613 RIKAMRGHGRSSIYSLAFS-REGTVLVSTGADNSVRVWD 650 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 71/425 (16%), Positives = 152/425 (35%), Gaps = 42/425 (9%) Query: 12 DSDLNFDEG-KSVHEKKNGNLHEDTSYEPSSNNIHKRKSHFTKSELK-RRRKTRKGDGPW 69 + +LN EG +H N ++ + S + +K+ K ++ K + + Sbjct: 247 EGELNLSEGIVELHTLNNTSIGGEQREISSVDAFNKKPVKLGKLQVDPEYSKELEAE--- 303 Query: 70 GSWSSSDDETSQASETQKEDQDIFVHALAED-NLDSEQIEVEEVSHFYGKSEKDYQGRGY 128 DE QA++ + + + + E ++ KS +D + Sbjct: 304 ---LKLKDEHEQAAQKKVSTTLLEEYRENFKVDPSDENNPSKDTLPLPLKSAQDLRNDIA 360 Query: 129 LYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIK 188 + + + L + S LP + + T LKF ++ SG D IK Sbjct: 361 MIQDSRAKIKLSAAQAS----LPSVCMYTFHNTNNDLTCLKFN-DDSTMVASGFQDSFIK 415 Query: 189 IWDFYHD--------------------YECLRDFQGHNKPIKALRFTEDCQSFLSSSFDR 228 +W + R GH+ + + F+ D + +S S D+ Sbjct: 416 LWSIDGSPLRSLLKNDPYNQQNNDGVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDK 475 Query: 229 SVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQT 288 +V++W +T +S+ H F + + ++ ++ Sbjct: 476 TVRLWSLDTYTCLVSYKGHSSSVWDVKFSPMGHYFATASHDQTARLW---SCDHIYPLRI 532 Query: 289 YDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQ 348 + HL+ + +++ P+ + + S DKT R+W+ ++ + ++ L V P Sbjct: 533 FAGHLNDVDCVEFHPNSTYLFTGSSDKTARMWDIARGECVR-VFMGHSGAINCLAVSPDG 591 Query: 349 NYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLF 408 + + D+ + + + K +GH + SLAFS +G + S + + + Sbjct: 592 RWLASAGEDSVVCLWDIST---GRRIKAMRGHGRSS-IYSLAFSREGTVLVSTGADNSVR 647 Query: 409 TWDWN 413 WD Sbjct: 648 VWDVK 652 Score = 172 bits (435), Expect = 3e-43, Method: Composition-based stats. Identities = 46/240 (19%), Positives = 88/240 (36%), Gaps = 14/240 (5%) Query: 108 EVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTA 167 V YG YL ++ D +R + + +Y GH Sbjct: 449 LVGHSGAVYGVDFSP--DNRYLISCSE-DKTVRLWSL-----DTYTCLVSYKGHSSSVWD 500 Query: 168 LKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFD 227 +KF P GH + +D T ++W H Y LR F GH + + F + + S D Sbjct: 501 VKFSP-MGHYFATASHDQTARLWSCDHIY-PLRIFAGHLNDVDCVEFHPNSTYLFTGSSD 558 Query: 228 RSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQ 287 ++ ++WD G+ +S + + + +S + +D ++ Sbjct: 559 KTARMWDIARGECVRVFMGHSGAINCLAVSPDGRWLASAGEDSVVCLWDISTGRR---IK 615 Query: 288 TYDHH-LSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHP 346 H SSI +L + +G+ +S+ D +VR+W+ + N + + + Sbjct: 616 AMRGHGRSSIYSLAFSREGTVLVSTGADNSVRVWDVKKNTNSPSAQPEPINDVTAQGIQK 675 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 18/118 (15%), Positives = 37/118 (31%), Gaps = 21/118 (17%) Query: 357 DNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSR 416 D+R + ++ H++ L F+ D + SG S + W + S Sbjct: 364 DSRAKIKLSAAQASLPSVCMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSP 423 Query: 417 LLNNIK--------------------IPGNKPITQVDWHPQETSKVICSGAAGKIYVC 454 L + +K + + + VD+ P + CS + + Sbjct: 424 LRSLLKNDPYNQQNNDGVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCS-EDKTVRLW 480 >4V6W-Ag nrPDB Length = 318 Score = 206 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 55/267 (20%), Positives = 107/267 (40%), Gaps = 15/267 (5%) Query: 156 RNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFT 215 + GH + + L G+ LSG D T+++WD + R F+GH K + ++ F+ Sbjct: 58 KRLYGHSHFISDV-VLSSDGNYALSGSWDQTLRLWDLAAG-KTTRRFEGHTKDVLSVAFS 115 Query: 216 EDCQSFLSSSFDRSVKIWDTETGKVKTRLH---LNSTPADVESRPTNPHEFIVGLSNSKI 272 D + +S S D+++K+W+T + K + + V P + + IV + Sbjct: 116 ADNRQIVSGSRDKTIKLWNTLA-ECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRT 174 Query: 273 LHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQIS 332 + + N L + H + + PDGS S +D +W+ + + Sbjct: 175 VKVWNLA--NCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLE 232 Query: 333 DTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKI----FKGHSSAGYGIS 388 + L P++ + C + I + L K + + +S Sbjct: 233 --HNDIINALCFSPNRYWLCVAYGPS-IKIWDLACKKTVEELRPEVVSPTSKADQPQCLS 289 Query: 389 LAFSGDGRYICSGDSKSRLFTWDWNTS 415 LA+S DG+ + +G S + + W + S Sbjct: 290 LAWSTDGQTLFAGYSDNTIRVWQVSVS 316 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 52/269 (19%), Positives = 104/269 (38%), Gaps = 28/269 (10%) Query: 119 SEKDYQGR---GYLYPPNDVDVDLR-------EERISFRCYL--PKKVIRNYPGHPEGTT 166 + Y + G+ + +DV + + R + K R + GH + Sbjct: 51 TNYGYPQKRLYGHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVL 110 Query: 167 ALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQS--FLSS 224 ++ F I+SG D TIK+W+ + + GH + +RF+ + + +S Sbjct: 111 SVAFSADNRQ-IVSGSRDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSC 169 Query: 225 SFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQG 284 +DR+VK+W+ K+K H ++ + + + G +SK L +D +N Sbjct: 170 GWDRTVKVWNLANCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLY 229 Query: 285 LVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQ-----ISDTAQHSM 339 + H I AL + P+ + +++IW+ +++ +S T++ Sbjct: 230 TL----EHNDIINALCFSPNRYWLCVAYG-PSIKIWDLACKKTVEELRPEVVSPTSKADQ 284 Query: 340 P---FLNVHPSQNYFCAQSMDNRIYSFSL 365 P L A DN I + + Sbjct: 285 PQCLSLAWSTDGQTLFAGYSDNTIRVWQV 313 >5WLC-LO nrPDB Length = 923 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 73/335 (21%), Positives = 129/335 (38%), Gaps = 49/335 (14%) Query: 131 PPNDVDVDLREERISFRC----------YLPKKVIRNYPGHPEGTTALKFLPKTGHLILS 180 P N V V+ E ++F + + I GH + T +L + P G +++ Sbjct: 304 PVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPD-GSRVVT 362 Query: 181 GGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDT----- 235 D IK+WD + CL F+ H + A++F + Q SSS D +V+ WD Sbjct: 363 ASEDGKIKVWDITSGF-CLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRN 421 Query: 236 -ETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLS 294 T R+ N D P+ L N I + + + L+ H Sbjct: 422 FRTFTGTERIQFNCLAVD----PSGEVVCAGSLDNFDIHVWSVQTGQ---LLDALSGHEG 474 Query: 295 SILALKYFPDGSKFISSSEDKTVRIW----ENQINVPIKQISDTAQHSMPFLNVHPSQNY 350 + L + + S S+S DKT+RIW +Q PI+ SD + L++ P Sbjct: 475 PVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSD-----VLALSMRPDGKE 529 Query: 351 FCAQSMDNRIYSFSLKPKYK-------------RHPKKIFKGHSSA--GYGISLAFSGDG 395 ++ +I F+++ + R + F +S + ++ +S DG Sbjct: 530 VAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDG 589 Query: 396 RYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPIT 430 I +G + + + +D LL + N + Sbjct: 590 MAIVAGGNNNSICLYDVPNEVLLKRFIVSRNMALN 624 Score = 143 bits (360), Expect = 2e-34, Method: Composition-based stats. Identities = 57/326 (17%), Positives = 120/326 (36%), Gaps = 24/326 (7%) Query: 133 NDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF 192 +VD+ RI+ + + + + + F P T L+ G +++D Sbjct: 239 EEVDISKYSWRITKKHF--------FYANQAKVKCVTFHPAT-RLLAVGFTSGEFRLYDL 289 Query: 193 YHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFD-RSVKIWDTETGKVKTRLHLNSTPA 251 D+ ++ P+ + + + S + +++ ++ + + Sbjct: 290 -PDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDST 348 Query: 252 DVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISS 311 + + + + + KI +D + T++ H SS+ A+++ G SS Sbjct: 349 NSLAYSPDGSRVVTASEDGKIKVWDITSG---FCLATFEEHTSSVTAVQFAKRGQVMFSS 405 Query: 312 SEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDN-RIYSFSLKPKYK 370 S D TVR W+ + + T + L V PS CA S+DN I+ +S++ Sbjct: 406 SLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQT--- 462 Query: 371 RHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDW-NTSRLLNNIKIPGNKPI 429 GH G L+FS + + S + W S+ + I++ + Sbjct: 463 GQLLDALSGH--EGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEV--YSDV 518 Query: 430 TQVDWHPQETSKVICSGAAGKIYVCD 455 + P +V S G+I + + Sbjct: 519 LALSMRPD-GKEVAVSTLKGQISIFN 543 Score = 105 bits (262), Expect = 4e-23, Method: Composition-based stats. Identities = 54/391 (13%), Positives = 106/391 (27%), Gaps = 89/391 (22%) Query: 143 RISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDF 202 R+S + K H + A+ L K G L++S D + +F R+ Sbjct: 36 RVSVFDLINNKSFTFEYEHRKNIAAID-LNKQGTLLISIDEDGRAILVNFKA-----RNV 89 Query: 203 QGH---NKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLH---------LNSTP 250 H + A++F+ D + F +S R ++IW T + + Sbjct: 90 LHHFNFKEKCSAVKFSPDGRLFALASG-RFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQD 148 Query: 251 ADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFIS 310 + + + + + E T++ H ++ + D K + Sbjct: 149 ITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYT 208 Query: 311 SSEDKTVRIWE--------------------------NQINVPIKQISDTAQHSMPFLNV 344 S+D V +WE + K Q + + Sbjct: 209 VSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTF 268 Query: 345 HPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKI---------------------------- 376 HP+ + L + Sbjct: 269 HPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLL 328 Query: 377 ------------FKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIP 424 +GH + SLA+S DG + + ++ WD + L + Sbjct: 329 VYEWQSESYILKQQGHFDSTN--SLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEH 386 Query: 425 GNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 +T V + + + S G + D Sbjct: 387 -TSSVTAVQF-AKRGQVMFSSSLDGTVRAWD 415 >6HHQ-h nrPDB Length = 319 Score = 203 bits (517), Expect = 9e-53, Method: Composition-based stats. Identities = 59/269 (21%), Positives = 112/269 (41%), Gaps = 14/269 (5%) Query: 155 IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRF 214 +R++ GH G LS D T+++WD E + F GH + ++ Sbjct: 58 VRSFKGHSHIVQDCTLTAD-GAYALSASWDKTLRLWDVATG-ETYQRFVGHKSDVMSVDI 115 Query: 215 TEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPT----NPHEFIVGLSNS 270 + +S S D+++K+W + + T L N + V P + I+ N Sbjct: 116 DKKASMIISGSRDKTIKVWTIKGQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGND 175 Query: 271 KILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQ 330 K++ + + + H S+I L PDG+ S+ +D + +W + Sbjct: 176 KMVKAWNL--NQFQIEADFIGHNSNINTLTASPDGTLIASAGKDGEIMLWNLAAKKAMYT 233 Query: 331 ISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKY---KRHPKKIFKGHSSAGYGI 387 +S AQ + L P++ + A + I FSL P+Y P+ ++ + + Sbjct: 234 LS--AQDEVFSLAFSPNRYWLAAATATG-IKVFSLDPQYLVDDLRPEFAGYSKAAEPHAV 290 Query: 388 SLAFSGDGRYICSGDSKSRLFTWDWNTSR 416 SLA+S DG+ + +G + + + W T+ Sbjct: 291 SLAWSADGQTLFAGYTDNVIRVWQVMTAN 319 Score = 82.6 bits (202), Expect = 4e-16, Method: Composition-based stats. Identities = 31/179 (17%), Positives = 61/179 (34%), Gaps = 19/179 (10%) Query: 288 TYDHHLSSILALKYFPDGS-KFISSSEDKTVRIW-----ENQINVPIKQISDTAQHSMPF 341 T + H + +L +S+S DKT+ W + + VP++ H + Sbjct: 12 TLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRS-FKGHSHIVQD 70 Query: 342 LNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSG 401 + Y + S D + + + + F GH S + + I SG Sbjct: 71 CTLTADGAYALSASWDKTLRLWDVATGETY---QRFVGHKSDVMSVDID--KKASMIISG 125 Query: 402 DSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQE-----TSKVICSGAAGKIYVCD 455 + W + L + + N ++QV P E + +I +G + + Sbjct: 126 SRDKTIKVWTIK-GQCLATL-LGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKAWN 182 Score = 46.7 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 21/134 (15%), Positives = 39/134 (29%), Gaps = 48/134 (35%) Query: 153 KVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLR------------ 200 ++ ++ GH L P G LI S G D I +W+ Sbjct: 187 QIEADFIGHNSNINTLTASPD-GTLIASAGKDGEIMLWNLAAKKAMYTLSAQDEVFSLAF 245 Query: 201 -------------------------------DFQGHNKPIK----ALRFTEDCQSFLSSS 225 +F G++K + +L ++ D Q+ + Sbjct: 246 SPNRYWLAAATATGIKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTLFAGY 305 Query: 226 FDRSVKIWDTETGK 239 D +++W T Sbjct: 306 TDNVIRVWQVMTAN 319 >5I2T-A nrPDB Length = 742 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 73/335 (21%), Positives = 129/335 (38%), Gaps = 49/335 (14%) Query: 131 PPNDVDVDLREERISFRC----------YLPKKVIRNYPGHPEGTTALKFLPKTGHLILS 180 P N V V+ E ++F + + I GH + T +L + P G +++ Sbjct: 329 PVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPD-GSRVVT 387 Query: 181 GGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDT----- 235 D IK+WD + CL F+ H + A++F + Q SSS D +V+ WD Sbjct: 388 ASEDGKIKVWDITSGF-CLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRN 446 Query: 236 -ETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLS 294 T R+ N D P+ L N I + + + L+ H Sbjct: 447 FRTFTGTERIQFNCLAVD----PSGEVVCAGSLDNFDIHVWSVQTGQ---LLDALSGHEG 499 Query: 295 SILALKYFPDGSKFISSSEDKTVRIW----ENQINVPIKQISDTAQHSMPFLNVHPSQNY 350 + L + + S S+S DKT+RIW +Q PI+ SD + L++ P Sbjct: 500 PVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSD-----VLALSMRPDGKE 554 Query: 351 FCAQSMDNRIYSFSLKPKYK-------------RHPKKIFKGHSSA--GYGISLAFSGDG 395 ++ +I F+++ + R + F +S + ++ +S DG Sbjct: 555 VAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAKNSERSKFFTTIHYSFDG 614 Query: 396 RYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPIT 430 I +G + + + +D LL + N + Sbjct: 615 MAIVAGGNNNSICLYDVPNEVLLKRFIVSRNMALN 649 Score = 141 bits (356), Expect = 5e-34, Method: Composition-based stats. Identities = 57/326 (17%), Positives = 120/326 (36%), Gaps = 24/326 (7%) Query: 133 NDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF 192 +VD+ RI+ + + + + + F P T L+ G +++D Sbjct: 264 EEVDISKYSWRITKKHF--------FYANQAKVKCVTFHPAT-RLLAVGFTSGEFRLYDL 314 Query: 193 YHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFD-RSVKIWDTETGKVKTRLHLNSTPA 251 D+ ++ P+ + + + S + +++ ++ + + Sbjct: 315 -PDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDST 373 Query: 252 DVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISS 311 + + + + + KI +D + T++ H SS+ A+++ G SS Sbjct: 374 NSLAYSPDGSRVVTASEDGKIKVWDITSG---FCLATFEEHTSSVTAVQFAKRGQVMFSS 430 Query: 312 SEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDN-RIYSFSLKPKYK 370 S D TVR W+ + + T + L V PS CA S+DN I+ +S++ Sbjct: 431 SLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQT--- 487 Query: 371 RHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDW-NTSRLLNNIKIPGNKPI 429 GH G L+FS + + S + W S+ + I++ + Sbjct: 488 GQLLDALSGH--EGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEV--YSDV 543 Query: 430 TQVDWHPQETSKVICSGAAGKIYVCD 455 + P +V S G+I + + Sbjct: 544 LALSMRPD-GKEVAVSTLKGQISIFN 568 Score = 104 bits (258), Expect = 1e-22, Method: Composition-based stats. Identities = 54/391 (13%), Positives = 106/391 (27%), Gaps = 89/391 (22%) Query: 143 RISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDF 202 R+S + K H + A+ L K G L++S D + +F R+ Sbjct: 61 RVSVFDLINNKSFTFEYEHRKNIAAID-LNKQGTLLISIDEDGRAILVNFKA-----RNV 114 Query: 203 QGH---NKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLH---------LNSTP 250 H + A++F+ D + F +S R ++IW T + + Sbjct: 115 LHHFNFKEKCSAVKFSPDGRLFALASG-RFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQD 173 Query: 251 ADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFIS 310 + + + + + E T++ H ++ + D K + Sbjct: 174 ITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYT 233 Query: 311 SSEDKTVRIWE--------------------------NQINVPIKQISDTAQHSMPFLNV 344 S+D V +WE + K Q + + Sbjct: 234 VSKDGAVFVWEFTKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTF 293 Query: 345 HPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKI---------------------------- 376 HP+ + L + Sbjct: 294 HPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLL 353 Query: 377 ------------FKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIP 424 +GH + SLA+S DG + + ++ WD + L + Sbjct: 354 VYEWQSESYILKQQGHFDSTN--SLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEEH 411 Query: 425 GNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 +T V + + + S G + D Sbjct: 412 -TSSVTAVQF-AKRGQVMFSSSLDGTVRAWD 440 Score = 48.3 bits (113), Expect = 7e-06, Method: Composition-based stats. Identities = 27/203 (13%), Positives = 53/203 (26%), Gaps = 49/203 (24%) Query: 299 LKYFPDGSK-----------------------------------------FISSSEDKTV 317 + + DG + IS ED Sbjct: 45 ITFSDDGKQLLSPVGNRVSVFDLINNKSFTFEYEHRKNIAAIDLNKQGTLLISIDEDGRA 104 Query: 318 RIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIF 377 + + + + + S + P F S + + K F Sbjct: 105 ILVNFKARNVLHHFNFKEKCS--AVKFSPDGRLFALASG-RFLQIWKTPDVNKDRQFAPF 161 Query: 378 KGHS-SAGY---GISLAFSGDGRYICSGDSKSRLFTWDWNT-SRLLNNIKIPGNKPITQV 432 H AG+ SL +S D R+I + W ++ + L G++ Sbjct: 162 VRHRVHAGHFQDITSLTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMG 221 Query: 433 DWHPQETSKVICSGAAGKIYVCD 455 + + K+ G ++V + Sbjct: 222 AFFSHDQEKIYTVSKDGAVFVWE 244 >1VYH-C nrPDB Length = 410 Score = 201 bits (510), Expect = 7e-52, Method: Composition-based stats. Identities = 74/431 (17%), Positives = 156/431 (36%), Gaps = 50/431 (11%) Query: 49 SHFTKSELKRR-RKTRKGDGPWGSWSSSDDETSQASETQKEDQDIFVHALAED--NLDSE 105 S + EL R + +G ++S E + +E + L + ++ Sbjct: 4 SQRQRDELNRAIADYLRSNGYEEAYSVFKKEAE--LDMNEELDKKYAGLLEKKWTSVIRL 61 Query: 106 QIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIR-NYPGHPEG 164 Q +V E+ ++++++ G L D + ++P+ + GH Sbjct: 62 QKKVMELESKLNEAKEEFTSGGPLGQKRD-----------PKEWIPRPPEKYALSGHRSP 110 Query: 165 TTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSS 224 T + F P +++S D TIK+WD+ + R +GH ++ + F + S Sbjct: 111 VTRVIFHPVF-SVMVSASEDATIKVWDYETG-DFERTLKGHTDSVQDISFDHSGKLLASC 168 Query: 225 SFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQG 284 S D ++K+WD + + +H + S N + + I ++ + Sbjct: 169 SADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWEVQTG---Y 225 Query: 285 LVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNV 344 V+T+ H + ++ DG+ S S D+TVR+W ++ + +H + ++ Sbjct: 226 CVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELRE-HRHVVECISW 284 Query: 345 HPS--------------------QNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAG 384 P + + S D I + + GH + Sbjct: 285 APESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGM---CLMTLVGHDN-- 339 Query: 385 YGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVIC 444 + + F G++I S L WD+ R + + + +T +D+H V+ Sbjct: 340 WVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHF-VTSLDFHKTA-PYVVT 397 Query: 445 SGAAGKIYVCD 455 + V + Sbjct: 398 GSVDQTVKVWE 408 Score = 194 bits (492), Expect = 8e-50, Method: Composition-based stats. Identities = 57/310 (18%), Positives = 111/310 (35%), Gaps = 34/310 (10%) Query: 126 RGYLYPPNDVDVDLREE-RISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGND 184 R +P V V E+ I Y R GH + + F +G L+ S D Sbjct: 113 RVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFD-HSGKLLASCSAD 171 Query: 185 HTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRL 244 TIK+WDF +EC+R GH+ + ++ + +S+S D+++K+W+ +TG Sbjct: 172 MTIKLWDF-QGFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKMWEVQTGYCVKTF 230 Query: 245 HLN-STPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFP 303 + V P I SN + + + + H + + + P Sbjct: 231 TGHREWVRMVR--PNQDGTLIASCSNDQTVRVWVVAT--KECKAELREHRHVVECISWAP 286 Query: 304 D--------------------GSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLN 343 + G +S S DKT+++W+ + + + + + + Sbjct: 287 ESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTL-VGHDNWVRGVL 345 Query: 344 VHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDS 403 H + + + D + + K K ++ + SL F Y+ +G Sbjct: 346 FHSGGKFILSCADDKTLRVWDYKNKRCMKTL-----NAHEHFVTSLDFHKTAPYVVTGSV 400 Query: 404 KSRLFTWDWN 413 + W+ Sbjct: 401 DQTVKVWECR 410 >6MZM-G nrPDB Length = 800 Score = 197 bits (501), Expect = 7e-51, Method: Composition-based stats. Identities = 54/217 (24%), Positives = 90/217 (41%), Gaps = 15/217 (6%) Query: 106 QIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERI-SFRCYLPKKVIRNYPGHPEG 164 +I YG S R YL ++ D +R + +F C + Y GH Sbjct: 537 KILYGHSGPVYGASFSP--DRNYLLSSSE-DGTVRLWSLQTFTC------LVGYKGHNYP 587 Query: 165 TTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSS 224 +F P G+ +SGG+D ++W Y+ LR F GH + RF + + Sbjct: 588 VWDTQFSPY-GYYFVSGGHDRVARLW-ATDHYQPLRIFAGHLADVNCTRFHPNSNYVATG 645 Query: 225 SFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQG 284 S DR+V++WD G + P + N G ++ ++L +D + Sbjct: 646 SADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDI---GHGL 702 Query: 285 LVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321 +V H ++ +L++ DG S S D TVR+W+ Sbjct: 703 MVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739 Score = 180 bits (457), Expect = 9e-46, Method: Composition-based stats. Identities = 43/213 (20%), Positives = 87/213 (40%), Gaps = 9/213 (4%) Query: 200 RDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTN 259 + GH+ P+ F+ D LSSS D +V++W +T ++ P Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 596 Query: 260 PHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRI 319 + F+ G + + +++ ++ + HL+ + ++ P+ + + S D+TVR+ Sbjct: 597 GYYFVSGGHDRVARLW---ATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRL 653 Query: 320 WENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKG 379 W+ ++ I + + L P+ + + D R+ + + KG Sbjct: 654 WDVLNGNCVR-IFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIG---HGLMVGELKG 709 Query: 380 HSSAGYGISLAFSGDGRYICSGDSKSRLFTWDW 412 H+ SL FS DG + SG + + WD Sbjct: 710 HTDTV--CSLRFSRDGEILASGSMDNTVRLWDA 740 Score = 176 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 40/210 (19%), Positives = 82/210 (39%), Gaps = 6/210 (2%) Query: 156 RNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFT 215 + GH F P + +LS D T+++W + CL ++GHN P+ +F+ Sbjct: 537 KILYGHSGPVYGASFSPDR-NYLLSSSEDGTVRLWSLQT-FTCLVGYKGHNYPVWDTQFS 594 Query: 216 EDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHY 275 F+S DR ++W T+ + + + N + G ++ + + Sbjct: 595 PYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLW 654 Query: 276 DDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTA 335 D N V+ + H I +L + P+G + + D V +W+ + + ++ Sbjct: 655 DVL---NGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL-KGH 710 Query: 336 QHSMPFLNVHPSQNYFCAQSMDNRIYSFSL 365 ++ L + SMDN + + Sbjct: 711 TDTVCSLRFSRDGEILASGSMDNTVRLWDA 740 Score = 159 bits (403), Expect = 2e-39, Method: Composition-based stats. Identities = 44/289 (15%), Positives = 95/289 (32%), Gaps = 42/289 (14%) Query: 198 CLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVK---------------- 241 C F + + A+ T+D D +V++ Sbjct: 462 CFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVXXXXXXXXXXXXXXXXXXXXXXXXX 521 Query: 242 ---------------TRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLV 286 L+ +S P S + + + + + + + + Sbjct: 522 XXXXXXXXXXXXXXXKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQT---FTCL 578 Query: 287 QTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHP 346 Y H + ++ P G F+S D+ R+W P++ I + HP Sbjct: 579 VGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLR-IFAGHLADVNCTRFHP 637 Query: 347 SQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSR 406 + NY S D + + + + +IF GH + SL FS +GR++ +G + R Sbjct: 638 NSNYVATGSADRTVRLWDV---LNGNCVRIFTGHKGPIH--SLTFSPNGRFLATGATDGR 692 Query: 407 LFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 + WD ++ +K + + + + ++ + + + D Sbjct: 693 VLLWDIGHGLMVGELKGHTDT-VCSLRFS-RDGEILASGSMDNTVRLWD 739 >3DM0-A nrPDB Length = 694 Score = 197 bits (500), Expect = 9e-51, Method: Composition-based stats. Identities = 58/321 (18%), Positives = 99/321 (30%), Gaps = 69/321 (21%) Query: 157 NYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECL----RDFQGHNKPIKAL 212 H + TA+ +I+S D +I +W D + R GH+ ++ + Sbjct: 377 TMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDV 436 Query: 213 RFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLN------------------------- 247 + D Q LS S+D +++WD G R + Sbjct: 437 VLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSASRDRTI 496 Query: 248 ---------------------STPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLV 286 + V P IV S K + + N L Sbjct: 497 KLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLS--NCKLR 554 Query: 287 QTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHP 346 T H + + PDGS S +D V +W+ + + A + L P Sbjct: 555 STLAGHTGYVSTVAVSPDGSLCASGGKDGVVLLWDLAEGKKLYSLE--ANSVIHALCFSP 612 Query: 347 SQNYFCAQSMDNRIYSFSLKPKYKRHPKKI--------------FKGHSSAGYGISLAFS 392 ++ + CA + ++ I + L+ K K+ Y SL +S Sbjct: 613 NRYWLCAAT-EHGIKIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKVIYCTSLNWS 671 Query: 393 GDGRYICSGDSKSRLFTWDWN 413 DG + SG + + W Sbjct: 672 ADGSTLFSGYTDGVIRVWGIG 692 >3JAP-g nrPDB Length = 326 Score = 195 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 58/299 (19%), Positives = 117/299 (39%), Gaps = 16/299 (5%) Query: 129 LYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIK 188 L D L R++ +R+Y GH + + G+ +S D T++ Sbjct: 33 LLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDV-VVSADGNYAVSASWDKTLR 91 Query: 189 IWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNS 248 +W+ R F GH + ++ + +S+S D+++++W+T L Sbjct: 92 LWNLATGNSEAR-FVGHTGDVLSVAIDANSSKIISASRDKTIRVWNTVGDCAYVLLGHTD 150 Query: 249 TPADVESRPTN--------PHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALK 300 V P N V KI+ ++ + + H + I ++ Sbjct: 151 WVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQ 210 Query: 301 YFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRI 360 PDGS S+ +D + +W + ++ A+ + L PS+ + A + I Sbjct: 211 PSPDGSLAASAGKDGQIYVWNLKHKSAF--MNFDAKDEVFALAFSPSRFWLTAATASG-I 267 Query: 361 YSFSLKPKYKRHPKKI-FKGHSSA--GYGISLAFSGDGRYICSGDSKSRLFTWDWNTSR 416 + L+ + K F G++ A + +SLA+S DG+ + +G + + + W T+ Sbjct: 268 KIYDLENEVLIDELKPEFAGYTKAQDPHAVSLAWSADGQTLFAGYTDNVIRVWQVMTAN 326 >5FL8-q nrPDB Length = 515 Score = 194 bits (492), Expect = 9e-50, Method: Composition-based stats. Identities = 65/372 (17%), Positives = 126/372 (33%), Gaps = 59/372 (15%) Query: 130 YPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKI 189 + + + + + + GH + + P G +I +G D+TI++ Sbjct: 154 HTSSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWVLCVSWSPD-GEVIATGSMDNTIRL 212 Query: 190 WDFYHDYECLRDFQGHNKPIKALRFTE-------DCQSFLSSSFDRSVKIWDTETGKVKT 242 WD +GH+K I +L + SSS D ++KIWDT + + Sbjct: 213 WDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQY 272 Query: 243 RLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYF 302 + ++ V + S+ + + D S+ + + H + L Sbjct: 273 TMSGHTN--SVSCVKWGGQGLLYSGSHDRTVRVWDINSQGR-CINILKSHAHWVNHLSLS 329 Query: 303 PDGSK---------------------------------------FISSSEDKTVRIWENQ 323 D + +++S+D T+ +W Sbjct: 330 TDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNPL 389 Query: 324 INVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSA 383 + Q + + P Y + S DN I + + F+GH ++ Sbjct: 390 KSTKPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGRD---GKFISTFRGHVAS 446 Query: 384 GYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKP-ITQVDWHPQETSKV 442 Y +A+S D R + S + L WD T +L ++ +PG+K + VDW +V Sbjct: 447 VY--QVAWSSDCRLLVSCSKDTTLKVWDVRTRKL--SVDLPGHKDEVYTVDWSVD-GKRV 501 Query: 443 ICSGAAGKIYVC 454 G + + Sbjct: 502 CSGGKDKMVRLW 513 Score = 187 bits (474), Expect = 9e-48, Method: Composition-based stats. Identities = 68/374 (18%), Positives = 127/374 (33%), Gaps = 68/374 (18%) Query: 138 DLREERISFRCYLPKKVIRN---------YPGHPEGTTALKFLPKTGHLILSGGNDHTIK 188 + E++I+ Y P+ V + GH F P T +++G D+T + Sbjct: 111 NSTEDQITL-LYTPRAVFKVKPVTRSSSAIAGHGSTILCSAFAPHTSSRMVTGAGDNTAR 169 Query: 189 IWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVK--TRLHL 246 IWD + +GH + + ++ D + + S D ++++WD ++G+ Sbjct: 170 IWDCDT-QTPMHTLKGHYNWVLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGH 228 Query: 247 NSTPADVESRPTN------PHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALK 300 + + P + + I +D + ++ T H +S+ +K Sbjct: 229 SKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWD---TVSRVCQYTMSGHTNSVSCVK 285 Query: 301 YFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVH--------------- 345 + G S S D+TVR+W+ I + H + L++ Sbjct: 286 WGGQG-LLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGK 344 Query: 346 ---------------------PSQN---YFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHS 381 + N S D ++ ++ P P GH Sbjct: 345 KPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWN--PLKSTKPIARMTGHQ 402 Query: 382 SAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSK 441 +AFS DGRYI S + + WD + ++ + + QV W Sbjct: 403 KLVNH--VAFSPDGRYIVSASFDNSIKLWDGRDGKFISTFRGH-VASVYQVAWSSDCRLL 459 Query: 442 VICSGAAGKIYVCD 455 V CS + V D Sbjct: 460 VSCS-KDTTLKVWD 472 >3MKQ-A nrPDB Length = 814 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 59/276 (21%), Positives = 113/276 (40%), Gaps = 14/276 (5%) Query: 104 SEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPE 163 Q+EV + +E + ++ N + V + RI Y + + ++ HP+ Sbjct: 43 ETQVEVRSIQ----VTETPVRAGKFIARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPD 98 Query: 164 GTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTE-DCQSFL 222 ++ P +LSG +D T+K+W++ +++ + F+GH + + F D +F Sbjct: 99 YIRSIAVHPTKP-YVLSGSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFA 157 Query: 223 SSSFDRSVKIWDTETGKVKTRL--HLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVS 280 S DR+VK+W L V+ P +++ S+ + D + Sbjct: 158 SGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQT 217 Query: 281 ENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMP 340 ++ V T + H+S++ + P IS SED T++IW + K ++ + S Sbjct: 218 KS--CVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERS-W 274 Query: 341 FLNVHPSQ--NYFCAQSMDNRIYSFSLKPKYKRHPK 374 + HP+ NY + DN SL Sbjct: 275 CIATHPTGRKNYIASG-FDNGFTVLSLGNDEPTLSL 309 Score = 152 bits (383), Expect = 4e-37, Method: Composition-based stats. Identities = 48/262 (18%), Positives = 101/262 (38%), Gaps = 12/262 (4%) Query: 197 ECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESR 256 + + F + +K + F L++ + V+IW+ ET + + TP Sbjct: 4 DIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKF 63 Query: 257 PTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKT 316 + IVG + +I ++ E V ++ H I ++ P +S S+D T Sbjct: 64 IARKNWIIVGSDDFRIRVFNYNTGEK---VVDFEAHPDYIRSIAVHPTKPYVLSGSDDLT 120 Query: 317 VRIWENQINVPIKQISDTAQHSMPFLNVHP-SQNYFCAQSMDNRIYSFSLKPKYKRHPKK 375 V++W + N ++Q + +H + + +P + F + +D + +SL Sbjct: 121 VKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLT 180 Query: 376 IFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVD-W 434 G + D Y+ + + WD+ T + ++ G+ + Sbjct: 181 T--GQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLE--GHMSNVSFAVF 236 Query: 435 HPQETSKVICSGA-AGKIYVCD 455 HP T +I SG+ G + + + Sbjct: 237 HP--TLPIIISGSEDGTLKIWN 256 Score = 148 bits (372), Expect = 7e-36, Method: Composition-based stats. Identities = 53/297 (17%), Positives = 111/297 (37%), Gaps = 13/297 (4%) Query: 156 RNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFT 215 + + + + F P +L+ ++IW++ E +R Q P++A +F Sbjct: 7 KTFSNRSDRVKGIDFHPTEP-WVLTTLYSGRVEIWNYETQVE-VRSIQVTETPVRAGKFI 64 Query: 216 EDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHY 275 + S D +++++ TG+ + + + G + + + Sbjct: 65 ARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLW 124 Query: 276 DDRVSENQGLVQTYDHHLSSILALKYFP-DGSKFISSSEDKTVRIWENQINVPIKQISDT 334 + N L QT++ H ++ + + P D S F S D+TV++W + P ++ Sbjct: 125 N--WENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTG 182 Query: 335 AQHSMPFLNVHP--SQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFS 392 + + +++ +P + Y S D I + + K +GH S F Sbjct: 183 QERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTK---SCVATLEGHMS--NVSFAVFH 237 Query: 393 GDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAG 449 I SG L W+ +T ++ + + G + + HP I SG Sbjct: 238 PTLPIIISGSEDGTLKIWNSSTYKVEKTLNV-GLERSWCIATHPTGRKNYIASGFDN 293 Score = 82.9 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 28/174 (16%), Positives = 61/174 (35%), Gaps = 8/174 (4%) Query: 282 NQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPF 341 + +T+ + + + + P +++ V IW + V ++ I T + Sbjct: 2 KLDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTET-PVRA 60 Query: 342 LNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSG 401 +N+ S D RI F+ +K+ + Y S+A Y+ SG Sbjct: 61 GKFIARKNWIIVGSDDFRIRVFNYNTG-----EKVVDFEAHPDYIRSIAVHPTKPYVLSG 115 Query: 402 DSKSRLFTWDWNTS-RLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVC 454 + W+W + L + + + V ++P++ S + V Sbjct: 116 SDDLTVKLWNWENNWALEQTFEGHEHF-VMCVAFNPKDPSTFASGCLDRTVKVW 168 >5XYI-g nrPDB Length = 335 Score = 190 bits (483), Expect = 8e-49, Method: Composition-based stats. Identities = 59/268 (22%), Positives = 107/268 (39%), Gaps = 18/268 (6%) Query: 158 YPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTED 217 GH + + HL+ S D T+++WD + F GH K + + F+ Sbjct: 76 LIGHNHFVSDVSLSRDASHLLTS-SWDSTLRLWDLST-RTTKKLFLGHKKDVLGVTFSPC 133 Query: 218 CQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRP----TNPHEFIVGLSNSKIL 273 + +S D VKIW+ G+ K L +S V P T+P VG + K+ Sbjct: 134 NRRIISVGRDNQVKIWNIL-GENKAELQCSSWVTSVACAPMADETSPLVIAVGCWDGKVY 192 Query: 274 HYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISD 333 + + L++ + H ++ + PDG I+ D+ V +W + K IS Sbjct: 193 IWSI--EKEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGA--KTISF 248 Query: 334 TAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGY------GI 387 TA + + P+Q + CA + + I + + K + + H Sbjct: 249 TAPSPVHAVAACPTQAWICAATYEG-IAVWDIGAKQQIDLVQPNFKHEGKRNAGRTPDCT 307 Query: 388 SLAFSGDGRYICSGDSKSRLFTWDWNTS 415 LA++ DG + SG + + W+ ++ Sbjct: 308 CLAWAADGSVLYSGYNDGSIRAWEVKSA 335 Score = 134 bits (336), Expect = 1e-31, Method: Composition-based stats. Identities = 53/270 (19%), Positives = 101/270 (37%), Gaps = 18/270 (6%) Query: 193 YHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVK-----TRLHLN 247 + F GHN I+++ + +S+S D+S +W + + TRL + Sbjct: 20 SAHFAPRATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGH 79 Query: 248 STPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSK 307 + S + + +S + +D + L + H +L + + P + Sbjct: 80 NHFVSDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKL---FLGHKKDVLGVTFSPCNRR 136 Query: 308 FISSSEDKTVRIWEN--QINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSL 365 IS D V+IW + ++ S + + S D ++Y +S+ Sbjct: 137 IISVGRDNQVKIWNILGENKAELQCSSWVTSVACAPMADETSPLVIAVGCWDGKVYIWSI 196 Query: 366 KPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPG 425 + + K K FK H G S+ F+ DG+++ +G S ++ W + P Sbjct: 197 EKEAKL--IKEFKAH--DGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGAKTISFTAP- 251 Query: 426 NKPITQVDWHPQETSKVICSGAAGKIYVCD 455 P+ V P + IC+ I V D Sbjct: 252 -SPVHAVAACPTQAW--ICAATYEGIAVWD 278 Score = 98.7 bits (244), Expect = 5e-21, Method: Composition-based stats. Identities = 48/265 (18%), Positives = 87/265 (32%), Gaps = 24/265 (9%) Query: 72 WSSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYP 131 + S + AS D + ++++ + G + R + Sbjct: 82 FVSDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPC-NRRIISV 140 Query: 132 PNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLP----KTGHLILSGGNDHTI 187 D V + I + T++ P + +I G D + Sbjct: 141 GRDNQVKI--WNILGENKAELQC-------SSWVTSVACAPMADETSPLVIAVGCWDGKV 191 Query: 188 KIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLN 247 IW + + +++F+ H+ ++ FT D + ++ DR V +W TE G Sbjct: 192 YIWSIEKEAKLIKEFKAHDGRCTSVDFTPDGKWVITGGSDRKVVMWLTENGAKTISFTAP 251 Query: 248 STPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLS--------SILAL 299 S V + PT +I + I +D + LVQ H L Sbjct: 252 SPVHAVAACPTQ--AWICAATYEGIAVWDIGAKQQIDLVQPNFKHEGKRNAGRTPDCTCL 309 Query: 300 KYFPDGSKFISSSEDKTVRIWENQI 324 + DGS S D ++R WE + Sbjct: 310 AWAADGSVLYSGYNDGSIRAWEVKS 334 >2YNP-A nrPDB Length = 604 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 59/276 (21%), Positives = 113/276 (40%), Gaps = 14/276 (5%) Query: 104 SEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPE 163 Q+EV + +E + ++ N + V + RI Y + + ++ HP+ Sbjct: 43 ETQVEVRSIQ----VTETPVRAGKFIARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPD 98 Query: 164 GTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTE-DCQSFL 222 ++ P +LSG +D T+K+W++ +++ + F+GH + + F D +F Sbjct: 99 YIRSIAVHPTKP-YVLSGSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFA 157 Query: 223 SSSFDRSVKIWDTETGKVKTRL--HLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVS 280 S DR+VK+W L V+ P +++ S+ + D + Sbjct: 158 SGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQT 217 Query: 281 ENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMP 340 ++ V T + H+S++ + P IS SED T++IW + K ++ + S Sbjct: 218 KS--CVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERS-W 274 Query: 341 FLNVHPSQ--NYFCAQSMDNRIYSFSLKPKYKRHPK 374 + HP+ NY + DN SL Sbjct: 275 CIATHPTGRKNYIASG-FDNGFTVLSLGNDEPTLSL 309 Score = 149 bits (375), Expect = 3e-36, Method: Composition-based stats. Identities = 47/262 (17%), Positives = 101/262 (38%), Gaps = 12/262 (4%) Query: 197 ECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESR 256 + + F + +K + F L++ + V++W+ ET + + TP Sbjct: 4 DIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKF 63 Query: 257 PTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKT 316 + IVG + +I ++ E V ++ H I ++ P +S S+D T Sbjct: 64 IARKNWIIVGSDDFRIRVFNYNTGEK---VVDFEAHPDYIRSIAVHPTKPYVLSGSDDLT 120 Query: 317 VRIWENQINVPIKQISDTAQHSMPFLNVHP-SQNYFCAQSMDNRIYSFSLKPKYKRHPKK 375 V++W + N ++Q + +H + + +P + F + +D + +SL Sbjct: 121 VKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLT 180 Query: 376 IFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVD-W 434 G + D Y+ + + WD+ T + ++ G+ + Sbjct: 181 T--GQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLE--GHMSNVSFAVF 236 Query: 435 HPQETSKVICSGA-AGKIYVCD 455 HP T +I SG+ G + + + Sbjct: 237 HP--TLPIIISGSEDGTLKIWN 256 Score = 145 bits (365), Expect = 4e-35, Method: Composition-based stats. Identities = 52/297 (17%), Positives = 111/297 (37%), Gaps = 13/297 (4%) Query: 156 RNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFT 215 + + + + F P +L+ +++W++ E +R Q P++A +F Sbjct: 7 KTFSNRSDRVKGIDFHPTEP-WVLTTLYSGRVELWNYETQVE-VRSIQVTETPVRAGKFI 64 Query: 216 EDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHY 275 + S D +++++ TG+ + + + G + + + Sbjct: 65 ARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLW 124 Query: 276 DDRVSENQGLVQTYDHHLSSILALKYFP-DGSKFISSSEDKTVRIWENQINVPIKQISDT 334 + N L QT++ H ++ + + P D S F S D+TV++W + P ++ Sbjct: 125 N--WENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTG 182 Query: 335 AQHSMPFLNVHP--SQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFS 392 + + +++ +P + Y S D I + + K +GH S F Sbjct: 183 QERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTK---SCVATLEGHMS--NVSFAVFH 237 Query: 393 GDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAG 449 I SG L W+ +T ++ + + G + + HP I SG Sbjct: 238 PTLPIIISGSEDGTLKIWNSSTYKVEKTLNV-GLERSWCIATHPTGRKNYIASGFDN 293 Score = 81.4 bits (199), Expect = 8e-16, Method: Composition-based stats. Identities = 27/174 (15%), Positives = 61/174 (35%), Gaps = 8/174 (4%) Query: 282 NQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPF 341 + +T+ + + + + P +++ V +W + V ++ I T + Sbjct: 2 KLDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTET-PVRA 60 Query: 342 LNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSG 401 +N+ S D RI F+ +K+ + Y S+A Y+ SG Sbjct: 61 GKFIARKNWIIVGSDDFRIRVFNYNTG-----EKVVDFEAHPDYIRSIAVHPTKPYVLSG 115 Query: 402 DSKSRLFTWDWNTS-RLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVC 454 + W+W + L + + + V ++P++ S + V Sbjct: 116 SDDLTVKLWNWENNWALEQTFEGHEHF-VMCVAFNPKDPSTFASGCLDRTVKVW 168 >6ID0-T nrPDB Length = 514 Score = 184 bits (467), Expect = 7e-47, Method: Composition-based stats. Identities = 77/443 (17%), Positives = 145/443 (32%), Gaps = 35/443 (7%) Query: 30 NLHEDTSYEPSSNNIHKRKSHFTKSELKRRRKTRKGDGPWGSWSS---SDDETSQASETQ 86 NL E + + +HK + ++ + G P+ + D Q ++ Sbjct: 64 NLKEKGPQNATDSYVHK---QYPANQGQEVEYFVAGTHPYPPGPGVALTADTKIQRMPSE 120 Query: 87 KEDQDIFVHALAEDNLDSEQ-IEVEEVSHFYGKSEKDYQ-GRGYLYPPNDVDVDLRE--- 141 Q + V + D+ + G S++ + + Sbjct: 121 SAAQSLAVALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMNSIVMETGNTKNSALMAK 180 Query: 142 ---ERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYEC 198 + + P K+ R GH + P ++G D TIKIWD + Sbjct: 181 KAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGN-QWFVTGSADRTIKIWDLASG-KL 238 Query: 199 LRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPT 258 GH ++ + + S D+ VK WD E KV H + + Sbjct: 239 KLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHP 298 Query: 259 NPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVR 318 + +S +D R + V T H +++ ++ + I+ S D T+R Sbjct: 299 TIDVLVTCSRDSTARIWDVRT---KASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIR 355 Query: 319 IWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFK 378 +W+ + + S+ + +HP F + S DN I + + Sbjct: 356 LWDLVAGKT-RVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQW---KFPDGSFIQNLS 410 Query: 379 GHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIK-------IPGNKPITQ 431 GH++ +L + DG + SG + WDW T + + I Sbjct: 411 GHNAIIN--TLTVNSDG-VLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFA 467 Query: 432 VDWHPQETSKVICSGAAGKIYVC 454 + E S+++ + A I V Sbjct: 468 CAFDQSE-SRLLTAEADKTIKVY 489 Score = 110 bits (275), Expect = 1e-24, Method: Composition-based stats. Identities = 46/261 (17%), Positives = 82/261 (31%), Gaps = 58/261 (22%) Query: 127 GYLYPPNDVDVDLRE-------ERISFRCYLPK--KVIRNYPGHPEGTTALKFLPKTGHL 177 G++ V V R E +C+ + KVIR+Y GH L P T + Sbjct: 244 GHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHP-TIDV 302 Query: 178 ILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTET 237 +++ D T +IWD + GH + +R ++ S D ++++WD Sbjct: 303 LVTCSRDSTARIWDVRTKAS-VHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVA 361 Query: 238 GKVKTRLHLNSTPADVESRPTNPHEFIVGL------------------------------ 267 GK + L + + F G Sbjct: 362 GKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTV 421 Query: 268 ----------SNSKILHYDDRVSENQGLVQ------TYDHHLSSILALKYFPDGSKFISS 311 N + +D R N V + D S I A + S+ +++ Sbjct: 422 NSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDS-ESGIFACAFDQSESRLLTA 480 Query: 312 SEDKTVRIWENQINVPIKQIS 332 DKT++++ + Sbjct: 481 EADKTIKVYREDDTATEETHP 501 >5NZU-C nrPDB Length = 905 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 61/340 (17%), Positives = 118/340 (34%), Gaps = 27/340 (7%) Query: 122 DYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSG 181 + ++ N V + +I Y + + + H + + P IL+ Sbjct: 59 PVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQP-FILTS 117 Query: 182 GNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTE-DCQSFLSSSFDRSVKIWDTETGKV 240 +D IK+WD+ + C + F+GH + + D F S+S DR++K+W + Sbjct: 118 SDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSP 177 Query: 241 KTRLHLNS-TPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILAL 299 L + ++ +++ ++ +++ D +N+ VQT + H ++ Sbjct: 178 NFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWD--YQNKTCVQTLEGHAQNVSCA 235 Query: 300 KYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNR 359 + P+ I+ SED TVRIW + ++ + + + + A D Sbjct: 236 SFHPELPIIITGSEDGTVRIWHSST-YRLESTLNYGMERVWCVA-SLRGSNNVALGYDEG 293 Query: 360 IYSFSLKPKYKRHPK----KIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTS 415 L + KI S +L GD Sbjct: 294 SIIVKLGREEPAMSMDANGKIIWAKHSEVQQANLKAMGDTEI-----KDG---------E 339 Query: 416 RLLNNIKIPGNKPIT--QVDWHPQETSKVICSGAAGKIYV 453 RL +K G+ I + +P V+C IY Sbjct: 340 RLPLAVKDMGSCEIYPQTIQHNPNGRFVVVCGDGEYIIYT 379 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 46/259 (17%), Positives = 97/259 (37%), Gaps = 9/259 (3%) Query: 197 ECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESR 256 + R + +K++ L+S ++ SV +W+ ET + + P Sbjct: 6 DIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKF 65 Query: 257 PTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKT 316 + + G + +I ++ E V ++ H I + P ++SS+D Sbjct: 66 VARKNWVVTGADDMQIRVFNYNTLER---VHMFEAHSDYIRCIAVHPTQPFILTSSDDML 122 Query: 317 VRIWENQINVPIKQISDTAQHSMPFLNVHP-SQNYFCAQSMDNRIYSFSLKPKYKRHPKK 375 +++W+ Q+ + H + + ++P N F + S+D I + L P Sbjct: 123 IKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSS---SPNF 179 Query: 376 IFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWH 435 +GH I GD Y+ SG + WD+ + ++ + ++ +H Sbjct: 180 TLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHA-QNVSCASFH 238 Query: 436 PQETSKVICSGAAGKIYVC 454 P E +I G + + Sbjct: 239 P-ELPIIITGSEDGTVRIW 256 Score = 151 bits (381), Expect = 6e-37, Method: Composition-based stats. Identities = 36/269 (13%), Positives = 106/269 (39%), Gaps = 13/269 (4%) Query: 156 RNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFT 215 R + ++ P ++ S + ++ +W+ + ++ F+ + P++A +F Sbjct: 9 RKLTARSDRVKSVDLHPTEPWMLASL-YNGSVCVWN-HETQTLVKTFEVCDLPVRAAKFV 66 Query: 216 EDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHY 275 ++ + D +++++ T + +S + + + I + Sbjct: 67 ARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLW 126 Query: 276 DDRVSENQGLVQTYDHHLSSILALKYFP-DGSKFISSSEDKTVRIWENQINVPIKQISDT 334 D + Q ++ H ++ + P D ++F S+S D+T+++W+ + P + + Sbjct: 127 D--WDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTL-EG 183 Query: 335 AQHSMPFLNVHPSQN--YFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFS 392 + + ++ + + Y + + D + + + K + +GH+ +F Sbjct: 184 HEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNK---TCVQTLEGHAQ--NVSCASFH 238 Query: 393 GDGRYICSGDSKSRLFTWDWNTSRLLNNI 421 + I +G + W +T RL + + Sbjct: 239 PELPIIITGSEDGTVRIWHSSTYRLESTL 267 >6QX9-4B nrPDB Length = 522 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 52/267 (19%), Positives = 96/267 (35%), Gaps = 22/267 (8%) Query: 154 VIRNYPGHPEGTTALKFLPKT-------GHLILSGGNDHTIKIWDFYHDYECLRDFQGHN 206 ++ GH A+ F PK+ + S D ++K+W D E + D +GH Sbjct: 265 LLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSD-EPVADIEGHT 323 Query: 207 KPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVG 266 + + + + ++ +DRS ++WD E + LH V + + G Sbjct: 324 VRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQE--EILHQEGHSMGVYDIAFHQDGSLAG 381 Query: 267 LSNSKI--LHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQI 324 +D R + + HL I + + P+G + S D T ++W+ + Sbjct: 382 TGGLDAFGRVWDLRTGR---CIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQ 438 Query: 325 NVPIKQISDTAQHSMPFLNVHP-SQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSA 383 + I Q+ + + P N+ + DN + P K GH Sbjct: 439 RRCVYTIPA-HQNLVTGVKFEPIHGNFLLTGAYDNTAKIW---THPGWSPLKTLAGHEGK 494 Query: 384 GYGISLAFSGDGRYICSGDSKSRLFTW 410 G+ + S DG+ I + W Sbjct: 495 VMGLDI--SSDGQLIATCSYDRTFKLW 519 Score = 153 bits (387), Expect = 1e-37, Method: Composition-based stats. Identities = 42/235 (17%), Positives = 91/235 (38%), Gaps = 9/235 (3%) Query: 132 PNDVDVDLREERISFRCY--LPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKI 189 P DV++ S + + + + + GH + + P +G + + D + ++ Sbjct: 291 PKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHP-SGRFLGTTCYDRSWRL 349 Query: 190 WDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNST 249 WD E L +GH+ + + F +D + D ++WD TG+ L + Sbjct: 350 WDLEAQEEILHQ-EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLK 408 Query: 250 PADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFP-DGSKF 308 + N + G ++ +D R + V T H + + +K+ P G+ Sbjct: 409 EIYGINFSPNGYHIATGSGDNTCKVWDLRQ---RRCVYTIPAHQNLVTGVKFEPIHGNFL 465 Query: 309 ISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSF 363 ++ + D T +IW + P+K ++ + + L++ S D + Sbjct: 466 LTGAYDNTAKIWTHPGWSPLKTLA-GHEGKVMGLDISSDGQLIATCSYDRTFKLW 519 Score = 145 bits (365), Expect = 5e-35, Method: Composition-based stats. Identities = 37/259 (14%), Positives = 84/259 (32%), Gaps = 18/259 (6%) Query: 204 GHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNS--------TPADVES 255 G ++PI F+ + + ++ + K+W + L ++ P S Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288 Query: 256 RPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDK 315 ++ + + E V + H + + + P G ++ D+ Sbjct: 289 LDPKDVNLASCAADGSVKLWSLDSDE---PVADIEGHTVRVARVMWHPSGRFLGTTCYDR 345 Query: 316 TVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKK 375 + R+W+ + I + + + H + +D + L+ Sbjct: 346 SWRLWDLEAQEEI-LHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRT---GRCIM 401 Query: 376 IFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWH 435 +GH Y + FS +G +I +G + WD R + I N +T V + Sbjct: 402 FLEGHLKEIY--GINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQN-LVTGVKFE 458 Query: 436 PQETSKVICSGAAGKIYVC 454 P + ++ + Sbjct: 459 PIHGNFLLTGAYDNTAKIW 477 Score = 100 bits (248), Expect = 2e-21, Method: Composition-based stats. Identities = 30/146 (20%), Positives = 52/146 (35%), Gaps = 9/146 (6%) Query: 91 DIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYL 150 D F + YG + ++ + Sbjct: 386 DAFGRVWDLRTGRCIMFLEGHLKEIYGINFSP--NGYHIAT------GSGDNTCKVWDLR 437 Query: 151 PKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIK 210 ++ + P H T +KF P G+ +L+G D+T KIW + + L+ GH + Sbjct: 438 QRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIW-THPGWSPLKTLAGHEGKVM 496 Query: 211 ALRFTEDCQSFLSSSFDRSVKIWDTE 236 L + D Q + S+DR+ K+W E Sbjct: 497 GLDISSDGQLIATCSYDRTFKLWMAE 522 >4V8M-A7 nrPDB Length = 318 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 55/309 (17%), Positives = 106/309 (34%), Gaps = 61/309 (19%) Query: 158 YPGHPEGTTALKF--LPKTGHLILSGGNDHTIKIWDFYHDYE--------CLRDFQGHNK 207 GH T+L P+T ++S D T+ W D R +GH+ Sbjct: 9 LTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSA 68 Query: 208 PIKALRFTEDCQSFLSSSFDRSVKIWDTETGKV--------------------------- 240 + + + + +S+S+D S+++W+ + G+ Sbjct: 69 FVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSPDNRQIVSGG 128 Query: 241 -----------------KTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQ 283 +R + V P+ IV ++ D + Sbjct: 129 RDNALRVWNVKGECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATG-- 186 Query: 284 GLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLN 343 LV H + + ++ PDGS SS +D R+W+ + +++ A + + Sbjct: 187 RLVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGA--PINQIC 244 Query: 344 VHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAG--YGISLAFSGDGRYICSG 401 P++ + CA + I F L+ K S +S+A+S DG + SG Sbjct: 245 FSPNRYWMCAATEKG-IRIFDLENKDIIVELAPEHQGSKKIVPECVSIAWSADGSTLYSG 303 Query: 402 DSKSRLFTW 410 + + + W Sbjct: 304 YTDNVIRVW 312 Score = 144 bits (364), Expect = 5e-35, Method: Composition-based stats. Identities = 46/270 (17%), Positives = 92/270 (34%), Gaps = 28/270 (10%) Query: 201 DFQGHNKPIKALRFTE---DCQSFLSSSFDRSVKIW---------DTETGKVKTRLHLNS 248 GH + +L + +S+S D+++ W + G RL +S Sbjct: 8 QLTGHRGWVTSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHS 67 Query: 249 TPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKF 308 + N + + + + ++ + + Q + H +L++ + PD + Sbjct: 68 AFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQY---KFLGHTKDVLSVAFSPDNRQI 124 Query: 309 ISSSEDKTVRIWENQINVPIKQISDT-AQHSMPFLNVHP--SQNYFCAQSMDNRIYSFSL 365 +S D +R+W + + +S + + P + DN + + L Sbjct: 125 VSGGRDNALRVWNVK-GECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDL 183 Query: 366 KPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPG 425 KGH++ Y S+ S DG S D WD L+ + Sbjct: 184 AT---GRLVTDLKGHTN--YVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEM--AA 236 Query: 426 NKPITQVDWHPQETSKVICSGAAGKIYVCD 455 PI Q+ + P +C+ I + D Sbjct: 237 GAPINQICFSPN--RYWMCAATEKGIRIFD 264 Score = 132 bits (331), Expect = 4e-31, Method: Composition-based stats. Identities = 45/263 (17%), Positives = 96/263 (36%), Gaps = 27/263 (10%) Query: 122 DYQGRGYLYPPNDVDVD-------LREERISFRCY--LPKKVIRNYPGHPEGTTALKFLP 172 D + G+ +DV + S R + + + GH + ++ F P Sbjct: 60 DRRLEGHSAFVSDVALSNNGNFAVSASWDHSLRLWNLQNGQCQYKFLGHTKDVLSVAFSP 119 Query: 173 KTGHLILSGGNDHTIKIWDFYHDYECLRDFQ--GHNKPIKALRFTE--DCQSFLSSSFDR 228 I+SGG D+ +++W+ EC+ H + +RF+ D +S +D Sbjct: 120 DNRQ-IVSGGRDNALRVWNV--KGECMHTLSRGAHTDWVSCVRFSPSLDAPVIVSGGWDN 176 Query: 229 SVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQT 288 VK+WD TG++ T L ++ + + + +D E + Sbjct: 177 LVKVWDLATGRLVTDLKGHTNYVTSVTVSPDGSLCASSDKDGVARLWDLTKGEALSEMAA 236 Query: 289 YDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFL------ 342 + I + + P+ ++ +K +RI++ + I +++ Q S + Sbjct: 237 ----GAPINQICFSPNRYWMC-AATEKGIRIFDLENKDIIVELAPEHQGSKKIVPECVSI 291 Query: 343 NVHPSQNYFCAQSMDNRIYSFSL 365 + + DN I + + Sbjct: 292 AWSADGSTLYSGYTDNVIRVWGV 314 >5Y88-O nrPDB Length = 451 Score = 171 bits (433), Expect = 5e-43, Method: Composition-based stats. Identities = 60/315 (19%), Positives = 115/315 (36%), Gaps = 23/315 (7%) Query: 149 YLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKP 208 + P K+ R GH + P ++G ND T+K+WD + GH Sbjct: 126 HAPWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATG-KLKTTLAGHVMT 184 Query: 209 IKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLS 268 ++ + ++ S S D++VK WD E ++ + + + S Sbjct: 185 VRDVAVSDRHPYLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLDLIATAGR 244 Query: 269 NSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPI 328 +S I +D R + V T H I ++ P + +SSS D TVR+W+ + Sbjct: 245 DSVIKLWDMRT---RIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTM 301 Query: 329 KQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGIS 388 K + + S+ +HP + + D I S+ L G + Sbjct: 302 K-VLTHHKRSVRATALHPKEFSVASACTD-DIRSWGLAEG----SLLTNFESEKTGIINT 355 Query: 389 LAFSGDGRYICSGDSKSRLFTWDWN---------TSRLLNNIKIPGNKPITQVDWHPQET 439 L+ + D + +G L +D+ T ++ +++ + + D + Sbjct: 356 LSINQDD-VLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEGERSVLCSTFD---KTG 411 Query: 440 SKVICSGAAGKIYVC 454 ++I A I + Sbjct: 412 LRLITGEADKSIKIW 426 Score = 145 bits (366), Expect = 3e-35, Method: Composition-based stats. Identities = 44/266 (16%), Positives = 100/266 (37%), Gaps = 13/266 (4%) Query: 191 DFYHDYECLRDFQGHNKPIKALRFTE-DCQSFLSSSFDRSVKIWDTETGKVKTRLHLNST 249 +++ ++ R GH ++ + D + F++ S D ++K+WD TGK+KT L + Sbjct: 124 EWHAPWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVM 183 Query: 250 PADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFI 309 + + H ++ +S K + D E +++ Y HLS + + P Sbjct: 184 TVRDVAVS-DRHPYLFSVSEDKTVKCWDL--EKNQIIRDYYGHLSGVRTVSIHPTLDLIA 240 Query: 310 SSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKY 369 ++ D +++W+ + +P+ + + + + P + S D + + + Sbjct: 241 TAGRDSVIKLWDMRTRIPVITL-VGHKGPINQVQCTPVDPQVVSSSTDATVRLWDV---V 296 Query: 370 KRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPI 429 K+ H + +L + S + + +W LL N + I Sbjct: 297 AGKTMKVLTHHKRSVRATALH--PKEFSVASACTD-DIRSWGLAEGSLLTNFESEKTGII 353 Query: 430 TQVDWHPQETSKVICSGAAGKIYVCD 455 + + + G G + D Sbjct: 354 NTL--SINQDDVLFAGGDNGVLSFYD 377 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 40/304 (13%), Positives = 94/304 (30%), Gaps = 17/304 (5%) Query: 110 EEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALK 169 + + ++ ND + + + K+ GH + Sbjct: 137 GHLGWVRCVAIDPVDNEWFITGSNDTTMKVWD-------LATGKLKTTLAGHVMTVRDVA 189 Query: 170 FLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRS 229 + + S D T+K WD + + +RD+ GH ++ + ++ D Sbjct: 190 VSDRHP-YLFSVSEDKTVKCWDLEKN-QIIRDYYGHLSGVRTVSIHPTLDLIATAGRDSV 247 Query: 230 VKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTY 289 +K+WD T L + P + + + +++ + +D + + Sbjct: 248 IKLWDMRTRIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMKV---L 304 Query: 290 DHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQN 349 HH S+ A P S+ D +R W + + L+++ + Sbjct: 305 THHKRSVRATALHPKEFSVASACTD-DIRSWGLAEGSLLTNFESEKTGIINTLSINQD-D 362 Query: 350 YFCAQSMDNRIYSFSLKPKYKRHPKKIFK---GHSSAGYGISLAFSGDGRYICSGDSKSR 406 A + + + K +K + + F G + +G++ Sbjct: 363 VLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEGERSVLCSTFDKTGLRLITGEADKS 422 Query: 407 LFTW 410 + W Sbjct: 423 IKIW 426 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 58/276 (21%), Positives = 92/276 (33%), Gaps = 65/276 (23%) Query: 127 GYLYPPNDVDVDLR-------EERISFRCYLPKK--VIRNYPGHPEGTTALKFLPKTGHL 177 G++ DV V R E + +C+ +K +IR+Y GH G + P T L Sbjct: 180 GHVMTVRDVAVSDRHPYLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHP-TLDL 238 Query: 178 ILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTET 237 I + G D IK+WD + GH PI ++ T +SSS D +V++WD Sbjct: 239 IATAGRDSVIKLWDMRTRIPVI-TLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVA 297 Query: 238 GKVKTRLHLNSTPADVESRPTN-------------------------------------- 259 GK L + + Sbjct: 298 GKTMKVLTHHKRSVRATALHPKEFSVASACTDDIRSWGLAEGSLLTNFESEKTGIINTLS 357 Query: 260 ---PHEFIVGLSNSKILHYDDRVSENQGLVQTYD-----HHLSSILALKYFPDGSKFISS 311 G N + YD + + T + S+L + G + I+ Sbjct: 358 INQDDVLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEGERSVLCSTFDKTGLRLITG 417 Query: 312 SEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPS 347 DK+++IW KQ + S P L +P+ Sbjct: 418 EADKSIKIW--------KQDETATKESEPGLAWNPN 445 >5Z56-q nrPDB Length = 504 Score = 168 bits (424), Expect = 6e-42, Method: Composition-based stats. Identities = 55/255 (21%), Positives = 102/255 (40%), Gaps = 14/255 (5%) Query: 205 HNKPI---KALRFTE-DCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNP 260 H+ I AL D L+ D++V ++D + ++ L ++ + Sbjct: 217 HSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQ 276 Query: 261 HEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 ++ I + N VQ H S++ L G +SSS+D+ Sbjct: 277 DLVFSASPDATIRIW---SVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFS 333 Query: 321 ENQINVPIKQISD-TAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKG 379 + Q + +++D T+ S+ HP F +MD++I + LK R F G Sbjct: 334 DIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKE---RTNVANFPG 390 Query: 380 HSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQET 439 HS G S+AFS +G Y+ + S + WD + +++ N + + + Q Sbjct: 391 HS--GPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFD-QSG 447 Query: 440 SKVICSGAAGKIYVC 454 + + G +IY+C Sbjct: 448 TYLALGGTDVQIYIC 462 Score = 152 bits (383), Expect = 3e-37, Method: Composition-based stats. Identities = 52/357 (14%), Positives = 122/357 (34%), Gaps = 23/357 (6%) Query: 105 EQIEVEEVSHFYGKSEKDYQGRGYLYPPN--DVDVDLREERISFRCYLPKKVIRNYPG-H 161 E +++ E+ + + Q + + + EE + + + ++ G H Sbjct: 158 EPMDLGELVGMTPEIIQKLQDKATVLTTERKKRGKTVPEELVKPEELSKYRQVASHVGLH 217 Query: 162 PE---GTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDC 218 G AL P + IL+GG D + ++D + + L +GH K + ++ F Sbjct: 218 SASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSE-QILATLKGHTKKVTSVVFHPSQ 276 Query: 219 QSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDR 278 S+S D +++IW + + + S + + D + Sbjct: 277 DLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQ 336 Query: 279 VSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHS 338 V S + ++ PDG F + + D ++IW+ + + + Sbjct: 337 TGRVLTKVTDETSGCS-LTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSG-P 394 Query: 339 MPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYI 398 + + + Y + D+ + + L+ ++ + SL F G Y+ Sbjct: 395 ITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQL----DNNFEVKSLIFDQSGTYL 450 Query: 399 CSGDSKSRLFT---WDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIY 452 G + +++ W + +L+ + G H + + +G + Sbjct: 451 ALGGTDVQIYICKQW----TEILHFTEHSGLTTGVAFGHHAKF---IASTGMDRSLK 500 Score = 128 bits (321), Expect = 5e-30, Method: Composition-based stats. Identities = 35/201 (17%), Positives = 77/201 (38%), Gaps = 11/201 (5%) Query: 256 RPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDK 315 P++ ++ + G ++ ++ +D + ++ T H + ++ + P S+S D Sbjct: 230 CPSDTNKILTGGADKNVVVFDKSSEQ---ILATLKGHTKKVTSVVFHPSQDLVFSASPDA 286 Query: 316 TVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKK 375 T+RIW N Q+ + ++ L++H + +Y + S D ++ Sbjct: 287 TIRIWSVP-NASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQY---WAFSDIQTGRVLT 342 Query: 376 IFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNK-PITQVDW 434 +S F DG +G S++ WD + N PG+ PIT + + Sbjct: 343 KVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANF--PGHSGPITSIAF 400 Query: 435 HPQETSKVICSGAAGKIYVCD 455 + + + + D Sbjct: 401 SEN-GYYLATAADDSSVKLWD 420 Score = 103 bits (257), Expect = 2e-22, Method: Composition-based stats. Identities = 43/332 (12%), Positives = 92/332 (27%), Gaps = 91/332 (27%) Query: 77 DETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYL----YPP 132 D+ + + +K+ L + E + +V+ G G L Sbjct: 178 DKATVLTTERKKRGKTVPEELVK---PEELSKYRQVASHVGLHSASIPGILALDLCPSDT 234 Query: 133 NDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF 192 N + ++ + ++++ GH + T++ F P + L+ S D TI+IW Sbjct: 235 NKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHP-SQDLVFSASPDATIRIWSV 293 Query: 193 YHDYECLRDFQGHNKPIKALR--------------------------------------- 213 + C++ + H + L Sbjct: 294 -PNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCS 352 Query: 214 -----FTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLS 268 F D F + + D +KIWD + +S P + N + Sbjct: 353 LTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAAD 412 Query: 269 NSKILHYDDRVSENQGLVQ--------------------------------------TYD 290 +S + +D R +N +Q + Sbjct: 413 DSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFT 472 Query: 291 HHLSSILALKYFPDGSKFISSSEDKTVRIWEN 322 H + + S+ D++++ + Sbjct: 473 EHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 504 >4V7E-Bg nrPDB Length = 380 Score = 167 bits (422), Expect = 9e-42, Method: Composition-based stats. Identities = 53/316 (16%), Positives = 108/316 (34%), Gaps = 17/316 (5%) Query: 154 VIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALR 213 R GH +L + P+ + I+S D + +W+ + + H + Sbjct: 58 CCRTLQGHSGKVYSLDWTPEK-NWIVSASQDGRLIVWNALTSQK-THAIKLHCPWVMECA 115 Query: 214 FTEDCQSFLSSSFDRSVKIWDTETG-------KVKTRLHLNSTPAD-VESRPTNPHEFIV 265 F + QS D + I++ + V L + A + P I Sbjct: 116 FAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETRLIT 175 Query: 266 GLSNSKILHYDDRVSENQGLVQT--YDHHLSSILALKYFP-DGSKFISSSEDKTVRIWEN 322 G + + +D + + + H + +L+L + + FIS S D TVR+W+ Sbjct: 176 GSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRLWDL 235 Query: 323 QINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSS 382 +I + + + + P F S D F ++ ++ + Sbjct: 236 RITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNREPDRND 295 Query: 383 A--GYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDW--HPQE 438 S+AFS GR + +G S + WD + ++ N+ N ++ + Sbjct: 296 NELPIVTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQNSHEGRISCLGLSSD 355 Query: 439 TSKVICSGAAGKIYVC 454 S + + + Sbjct: 356 GSALCTGSWDKNLKIW 371 Score = 35.2 bits (79), Expect = 0.058, Method: Composition-based stats. Identities = 12/49 (24%), Positives = 17/49 (34%), Gaps = 11/49 (22%) Query: 161 HPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPI 209 H + L G + +G D +KIW F GH K + Sbjct: 343 HEGRISCLGLSSD-GSALCTGSWDKNLKIW----------AFSGHRKIV 380 >5G04-R nrPDB Length = 499 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 67/385 (17%), Positives = 134/385 (34%), Gaps = 57/385 (14%) Query: 73 SSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPP 132 S + + + T+KE Q + AL + D E+ ++ +S + + YQ R + Sbjct: 96 SKENQPENSQTPTKKEHQKAW--ALNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYS 153 Query: 133 NDVDVDLREERISFRCYLPKKVIRNYPG-HPEGTTALKFLPKTGHLILSGGNDHTIKIWD 191 + + LP +++ + + + +G+++ D+++ +W Sbjct: 154 QKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWS--SGNVLAVA-LDNSVYLWS 210 Query: 192 FYHDYECLRDFQGHN--KPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNST 249 + L+ Q + I ++ + ++ + V++WD + K ++ S Sbjct: 211 ASSG-DILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDV--QQQKRLRNMTSH 267 Query: 250 PADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFI 309 A V S N + G + I H+D RV+E+ V T H + L++ PDG Sbjct: 268 SARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHH--VATLSGHSQEVCGLRWAPDGRHLA 325 Query: 310 SSSEDKTVRIWEN---QINVPIKQISDTAQHSMPFLNVHPSQNYFCA---QSMDNRIYSF 363 S D V +W + + Q Q ++ + P Q+ A + D I + Sbjct: 326 SGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW 385 Query: 364 SLKPKYKRHP----------------KKIFKGHSSAGY---------------------- 385 ++ K++ GH A Sbjct: 386 NVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSR 445 Query: 386 GISLAFSGDGRYICSGDSKSRLFTW 410 +SL S DG + S + L W Sbjct: 446 VLSLTMSPDGATVASAAADETLRLW 470 Score = 148 bits (374), Expect = 4e-36, Method: Composition-based stats. Identities = 43/250 (17%), Positives = 92/250 (36%), Gaps = 15/250 (6%) Query: 103 DSEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHP 162 D +Q + + Y+ + + + + GH Sbjct: 254 DVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEH----HVATLSGHS 309 Query: 163 EGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD---YECLRDFQGHNKPIKALRFTEDCQ 219 + L++ P H + SGGND+ + +W + L+ F H +KA+ + Sbjct: 310 QEVCGLRWAPDGRH-LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQS 368 Query: 220 SFLS---SSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFI-VGLSNSKILHY 275 + L+ + DR ++IW+ +G + + +S + P G + ++++ + Sbjct: 369 NVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIW 428 Query: 276 DDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTA 335 V H S +L+L PDG+ S++ D+T+R+W P ++ Sbjct: 429 K---YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREK 485 Query: 336 QHSMPFLNVH 345 + +H Sbjct: 486 ASAAKSSLIH 495 Score = 88.7 bits (218), Expect = 5e-18, Method: Composition-based stats. Identities = 26/203 (12%), Positives = 69/203 (33%), Gaps = 13/203 (6%) Query: 258 TNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTV 317 + + ++ + + + L+Q I ++ + +G+ + V Sbjct: 192 WSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGE-YISSVAWIKEGNYLAVGTSSAEV 250 Query: 318 RIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIF 377 ++W+ Q ++ ++ HS ++ + + S I+ ++ Sbjct: 251 QLWDVQQQKRLRNMTS---HSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHH--VATL 305 Query: 378 KGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSR---LLNNIKIPGNKPITQVDW 434 GHS L ++ DGR++ SG + + + W + + V W Sbjct: 306 SGHSQEV--CGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAW 363 Query: 435 HPQETSKVICSGA--AGKIYVCD 455 P +++ + G I + + Sbjct: 364 CPWQSNVLATGGGTSDRHIRIWN 386 >5OQL-d nrPDB Length = 446 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 65/303 (21%), Positives = 116/303 (38%), Gaps = 21/303 (6%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQ 219 GH +G ++ + + I SG D +K+WD E HN +K L FT D + Sbjct: 64 GHVQGVYSMCKDKNSLNCIASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTFTND-K 122 Query: 220 SFLSSSFDRSVKIWDTETGKVKTR---LHLNSTPADVESRPTNPHEFIVGLSNSKILHYD 276 LS + D +K+WD T P S + + F I +D Sbjct: 123 KLLSCATDG-IKLWDPYASPSNTTPIATWQEGGPYTSLSFHRSANTFAASSGQGCIRIWD 181 Query: 277 DRVSENQGLVQTYDHHLSSILALKYFP-DGSKFISSSEDKTVRIWENQINVP-IKQISDT 334 S +Q + + +I + + + S S + D+++ +++ + N+P IK + Sbjct: 182 LEHSTAGQAIQ-WPSFVDTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLHF 240 Query: 335 AQHSMPFLNVHPSQNY-FCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSG 393 A + + +P + S D+ IY F + K I KGH +A + FS Sbjct: 241 ACNRI---VFNPMEAMNLAVASEDHNIYIFDARNFDK--ALNIQKGHVAAVMDVE--FSP 293 Query: 394 DGRYICSGDSKSRLFTW--DWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKI 451 G + SG + W D SR + + K + + + W ++ G + Sbjct: 294 TGEELVSGSYDRTIRLWRRDAGHSRDVYHTK--RMQRVFRTMWTMDS-KYILTGSDDGNV 350 Query: 452 YVC 454 + Sbjct: 351 RLW 353 Score = 81.4 bits (199), Expect = 7e-16, Method: Composition-based stats. Identities = 30/154 (19%), Positives = 56/154 (36%), Gaps = 3/154 (1%) Query: 136 DVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD 195 V I F VI+ H + F P + DH I I+D + Sbjct: 215 SVATDRSIILFDLRTNMPVIKTVL-HFAC-NRIVFNPMEAMNLAVASEDHNIYIFDARNF 272 Query: 196 YECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVES 255 + L +GH + + F+ + +S S+DR++++W + G + H + Sbjct: 273 DKALNIQKGHVAAVMDVEFSPTGEELVSGSYDRTIRLWRRDAGHSRDVYHTKRMQRVFRT 332 Query: 256 RPT-NPHEFIVGLSNSKILHYDDRVSENQGLVQT 288 T + + G + + + SE G+ T Sbjct: 333 MWTMDSKYILTGSDDGNVRLWRANASERSGVKAT 366 Score = 74.1 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 27/167 (16%), Positives = 59/167 (35%), Gaps = 8/167 (4%) Query: 163 EGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTE-DCQSF 221 + T + F +I S D +I ++D + ++ + F + + Sbjct: 198 DTITDVCFNQVETSVIGSVATDRSIILFDLRTNMPVIKTVLHF--ACNRIVFNPMEAMNL 255 Query: 222 LSSSFDRSVKIWDTETGKVKTRLH--LNSTPADVESRPTNPHEFIVGLSNSKILHYDDRV 279 +S D ++ I+D + + DVE PT E + G + I + Sbjct: 256 AVASEDHNIYIFDARNFDKALNIQKGHVAAVMDVEFSPTGE-ELVSGSYDRTIRLWRRDA 314 Query: 280 SENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINV 326 ++ + T + + + D ++ S+D VR+W + Sbjct: 315 GHSRDVYHTKR--MQRVFRTMWTMDSKYILTGSDDGNVRLWRANASE 359 >5WBU-D nrPDB Length = 328 Score = 166 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 58/306 (18%), Positives = 107/306 (34%), Gaps = 18/306 (5%) Query: 141 EERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF-YHDYECL 199 + + F R AL+ P +I + G H I+++D ++ + Sbjct: 23 DHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDR-SMIAAAGYQH-IRMYDLNSNNPNPI 80 Query: 200 RDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKT-RLHLNSTPADVESRPT 258 + G NK I ++ F ED + + D + +IWD + ++ R+ + P + Sbjct: 81 ISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHP 140 Query: 259 NPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVR 318 N E IVG + I +D + N+ L+ + SI + PD S + + Sbjct: 141 NQAELIVGDQSGAIHIWDLKTDHNEQLIPEPE---VSITSAHIDPDASYMAAVNSTGNCY 197 Query: 319 IWENQINVPIKQISDTAQHSMPF-------LNVHPSQNYFCAQSMDNRIYSF---SLKPK 368 +W + + + +P P S D + + Sbjct: 198 VWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLM 257 Query: 369 YKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKP 428 + K G SS G+ AFSGD +YI + S + W T + K Sbjct: 258 TELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGH-QKA 316 Query: 429 ITQVDW 434 + + + Sbjct: 317 VVCLAF 322 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 40/246 (16%), Positives = 78/246 (31%), Gaps = 15/246 (6%) Query: 216 EDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHY 275 D ++ +D +V+ W +G + + + + + Sbjct: 12 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH--IRM 69 Query: 276 DDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTA 335 D S N + +YD +I ++ + DG + ED T RIW+ + Q Sbjct: 70 YDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV 129 Query: 336 QHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDG 395 + + +HP+Q I+ + LK + S D Sbjct: 130 NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIP-----EPEVSITSAHIDPDA 184 Query: 396 RYICSGDSKSRLFTWDWN------TSRLLNNIKIPGNK-PITQVDWHPQETSKVICSGAA 448 Y+ + +S + W+ ++L+ KIP + Q + P T CS Sbjct: 185 SYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSA-D 243 Query: 449 GKIYVC 454 + Sbjct: 244 QTCKIW 249 Score = 68.3 bits (165), Expect = 7e-12, Method: Composition-based stats. Identities = 25/155 (16%), Positives = 47/155 (30%), Gaps = 17/155 (10%) Query: 164 GTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYE-------CLRDFQGHNKPIKALRFTE 216 T+ P ++ +W+ H + RF+ Sbjct: 174 SITSAHIDPDASYMAAVNST-GNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP 232 Query: 217 DCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPT-------NPHEFIVGLSN 269 D + S D++ KIW T + T L + S SR ++IV S+ Sbjct: 233 DSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASS 292 Query: 270 SKILHYDDRVSENQGLVQTYDHHLSSILALKYFPD 304 + E + + Y H +++ L + Sbjct: 293 DNLARLW--CVETGEIKREYGGHQKAVVCLAFNDS 325 Score = 64.8 bits (156), Expect = 6e-11, Method: Composition-based stats. Identities = 20/110 (18%), Positives = 41/110 (37%), Gaps = 10/110 (9%) Query: 158 YPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDF--------QGHNKPI 209 P H +F P + L+ + D T KIW ++ + + + + Sbjct: 218 IPAHTRYALQCRFSPDS-TLLATCSADQTCKIWR-TSNFSLMTELSIKSGNPGESSRGWM 275 Query: 210 KALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTN 259 F+ D Q +++S D ++W ETG++K + + + Sbjct: 276 WGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 325 >3FM0-A nrPDB Length = 345 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 56/288 (19%), Positives = 104/288 (36%), Gaps = 26/288 (9%) Query: 149 YLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD-YECLRDFQGHNK 207 ++ K V+ GH + + P G+ + S D T IW D +EC+ +GH Sbjct: 50 WICKSVLS--EGHQRTVRKVAWSPC-GNYLASASFDATTCIWKKNQDDFECVTTLEGHEN 106 Query: 208 PIKALRFTEDCQSFLSSSFDRSVKIWDT-ETGKVKTRLHLNSTPADVESRPTNPH-EFIV 265 +K++ + + S D+SV +W+ E + + LNS DV+ +P E + Sbjct: 107 EVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLA 166 Query: 266 GLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQIN 325 S + ++ T + H S++ +L + P G + S S+D+TVRIW + Sbjct: 167 SASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLP 226 Query: 326 VPIKQISDTAQHSMPFL-----NVHPSQNY----------FCAQSMDNRIYSFSLKP-KY 369 + ++ + H Y D+ I F P Sbjct: 227 GNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSD 286 Query: 370 KRHPKKIFKGHSSAGY---GISLAFSGDGR-YICSGDSKSRLFTWDWN 413 + P H + +A++ + S + W + Sbjct: 287 PQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQ 334 Score = 148 bits (374), Expect = 4e-36, Method: Composition-based stats. Identities = 51/328 (15%), Positives = 112/328 (34%), Gaps = 30/328 (9%) Query: 154 VIRNYPGHPEG-TTALKFLPKTGHLILSGGNDHTIKIWDFYHD-YECLRDF-QGHNKPIK 210 ++ P HP+ L + P G L+ S G D I+IW D + C +GH + ++ Sbjct: 7 LLGRVPAHPDSRCWFLAWNPA-GTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVR 65 Query: 211 ALRFTEDCQSFLSSSFDRSVKIW--DTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLS 268 + ++ S+SFD + IW + + + T L + + + + Sbjct: 66 KVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSR 125 Query: 269 NSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW-ENQINVP 327 + + ++ + V + H + + + P S+S D TV+++ E + + Sbjct: 126 DKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWV 185 Query: 328 IKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFS------------LKPKYKRHPKK 375 + + ++ L PS + S D + + Sbjct: 186 CCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCIC 245 Query: 376 IFKG-HSSAGYGISLAFSGDGRYICSGDSKSRLFTWD--------WNTSRLLNNIKIPGN 426 G HS Y +A+ + + + + T L ++ + Sbjct: 246 TLSGFHSRTIY--DIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHS 303 Query: 427 KPITQVDWHPQETSKVICSGAAGKIYVC 454 + + V W+P+E + G++ Sbjct: 304 QDVNCVAWNPKEPGLLASCSDDGEVAFW 331 Score = 104 bits (259), Expect = 8e-23, Method: Composition-based stats. Identities = 42/262 (16%), Positives = 75/262 (28%), Gaps = 28/262 (10%) Query: 91 DIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYL 150 D ++ D E + E KS L D Sbjct: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLAT---CSRDKSVWVWEVDEED 138 Query: 151 PKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIW-DFYHDYECLRDFQGHNKPI 209 + + H + + + P + L+ S D T+K++ + D+ C +GH + Sbjct: 139 EYECVSVLNSHTQDVKHVVWHP-SQELLASASYDDTVKLYREEEDDWVCCATLEGHESTV 197 Query: 210 KALRFTEDCQSFLSSSFDRSVKIW----------------DTETGKVKTRLHLNSTPADV 253 +L F Q S S DR+V+IW D + T +S Sbjct: 198 WSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYD 257 Query: 254 ESRPTNPHEFIVGLSNSKILHY------DDRVSENQGLVQTYDHHLSSILALKYFPDGS- 306 + + I + D + + H + + + P Sbjct: 258 IAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPG 317 Query: 307 KFISSSEDKTVRIWENQINVPI 328 S S+D V W+ Q + Sbjct: 318 LLASCSDDGEVAFWKYQRPEGL 339 Score = 67.1 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 22/132 (16%), Positives = 46/132 (34%), Gaps = 6/132 (4%) Query: 326 VPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGY 385 V + ++ FL +P+ + D RI + + + +GH Sbjct: 6 VLLGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVR 65 Query: 386 GISLAFSGDGRYICSGDSKSRLFTW--DWNTSRLLNNIKIPGNKPITQVDWHPQETSKVI 443 +A+S G Y+ S + W + + + ++ N+ + V W P Sbjct: 66 --KVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENE-VKSVAWAPSGNLLAT 122 Query: 444 CSGAAGKIYVCD 455 CS ++V + Sbjct: 123 CS-RDKSVWVWE 133 >4GGA-A nrPDB Length = 420 Score = 164 bits (415), Expect = 7e-41, Method: Composition-based stats. Identities = 67/385 (17%), Positives = 134/385 (34%), Gaps = 57/385 (14%) Query: 73 SSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPP 132 S + + + T+KE Q + AL + D E+ ++ +S + + YQ R + Sbjct: 17 SKENQPENSQTPTKKEHQKAW--ALNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYS 74 Query: 133 NDVDVDLREERISFRCYLPKKVIRNYPG-HPEGTTALKFLPKTGHLILSGGNDHTIKIWD 191 + + LP +++ + + + +G+++ D+++ +W Sbjct: 75 QKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWS--SGNVLAVA-LDNSVYLWS 131 Query: 192 FYHDYECLRDFQGHN--KPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNST 249 + L+ Q + I ++ + ++ + V++WD + K ++ S Sbjct: 132 ASSG-DILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDV--QQQKRLRNMTSH 188 Query: 250 PADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFI 309 A V S N + G + I H+D RV+E+ V T H + L++ PDG Sbjct: 189 SARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHH--VATLSGHSQEVCGLRWAPDGRHLA 246 Query: 310 SSSEDKTVRIWEN---QINVPIKQISDTAQHSMPFLNVHPSQNYFCA---QSMDNRIYSF 363 S D V +W + + Q Q ++ + P Q+ A + D I + Sbjct: 247 SGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW 306 Query: 364 SLKPKYKRHP----------------KKIFKGHSSAGY---------------------- 385 ++ K++ GH A Sbjct: 307 NVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSR 366 Query: 386 GISLAFSGDGRYICSGDSKSRLFTW 410 +SL S DG + S + L W Sbjct: 367 VLSLTMSPDGATVASAAADETLRLW 391 Score = 146 bits (369), Expect = 1e-35, Method: Composition-based stats. Identities = 43/250 (17%), Positives = 92/250 (36%), Gaps = 15/250 (6%) Query: 103 DSEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHP 162 D +Q + + Y+ + + + + GH Sbjct: 175 DVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEH----HVATLSGHS 230 Query: 163 EGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD---YECLRDFQGHNKPIKALRFTEDCQ 219 + L++ P H + SGGND+ + +W + L+ F H +KA+ + Sbjct: 231 QEVCGLRWAPDGRH-LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQS 289 Query: 220 SFLS---SSFDRSVKIWDTETGKVKTRLHLNSTPADVESRP-TNPHEFIVGLSNSKILHY 275 + L+ + DR ++IW+ +G + + +S + P G + ++++ + Sbjct: 290 NVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIW 349 Query: 276 DDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTA 335 V H S +L+L PDG+ S++ D+T+R+W P ++ Sbjct: 350 K---YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREK 406 Query: 336 QHSMPFLNVH 345 + +H Sbjct: 407 ASAAKSSLIH 416 Score = 87.6 bits (215), Expect = 1e-17, Method: Composition-based stats. Identities = 26/203 (12%), Positives = 69/203 (33%), Gaps = 13/203 (6%) Query: 258 TNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTV 317 + + ++ + + + L+Q I ++ + +G+ + V Sbjct: 113 WSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGE-YISSVAWIKEGNYLAVGTSSAEV 171 Query: 318 RIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIF 377 ++W+ Q ++ ++ HS ++ + + S I+ ++ Sbjct: 172 QLWDVQQQKRLRNMTS---HSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHH--VATL 226 Query: 378 KGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSR---LLNNIKIPGNKPITQVDW 434 GHS L ++ DGR++ SG + + + W + + V W Sbjct: 227 SGHSQEV--CGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAW 284 Query: 435 HPQETSKVICSGA--AGKIYVCD 455 P +++ + G I + + Sbjct: 285 CPWQSNVLATGGGTSDRHIRIWN 307 >4BTS-AR nrPDB Length = 343 Score = 164 bits (415), Expect = 7e-41, Method: Composition-based stats. Identities = 53/281 (18%), Positives = 110/281 (39%), Gaps = 30/281 (10%) Query: 156 RNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFT 215 + GH + L L + +S D T+++WD + F GH + ++ F+ Sbjct: 70 KALTGHNHFVSDLA-LSQENCFAISSSWDKTLRLWDLRTG-TTYKRFVGHQSEVYSVAFS 127 Query: 216 EDCQSFLSSSFDRSVKIWDTETGKVKTRL----HLNSTPADVESRP---------TNPHE 262 D + LS+ +R +K+W+ G+ K + + + V P Sbjct: 128 PDNRQILSAGAEREIKLWNIL-GECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPY 186 Query: 263 FIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWEN 322 F + ++ ++ N + T+ H S++ L P+G + +DK + IW+ Sbjct: 187 FASVGWDGRLKVWN----TNFQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKLLIWDI 242 Query: 323 QINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKR-------HPKK 375 +N+ Q A ++ + +P + + D + F+L + K P Sbjct: 243 -LNLTYPQREFDAGSTINQIAFNPKLQWVAVGT-DQGVKIFNLMTQSKAPVCTIEAEPIT 300 Query: 376 IFKG-HSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTS 415 +G SLA++ G+ + +G + + T+ + TS Sbjct: 301 KAEGQKGKNPQCTSLAWNALGKKLFAGFTDGVIRTFSFETS 341 Score = 157 bits (397), Expect = 7e-39, Method: Composition-based stats. Identities = 44/278 (15%), Positives = 110/278 (39%), Gaps = 30/278 (10%) Query: 158 YPGHPEGTTAL-----KFLPKTGHLILSGGNDHTIKIWDFYHDYE------CLRDFQGHN 206 GH + T++ + + +++SG D T+ IW Y + + + GHN Sbjct: 17 LEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGHN 76 Query: 207 KPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVG 266 + L +++ +SSS+D+++++WD TG R + + + + + + Sbjct: 77 HFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYKRFVGHQSEVYSVAFSPDNRQILSA 136 Query: 267 LSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPD----------GSKFISSSEDKT 316 + +I ++ E + ++H + ++Y P F S D Sbjct: 137 GAEREIKLWNIL-GECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVGWDGR 195 Query: 317 VRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKI 376 +++W N I+ + ++ L++ P+ Y D ++ + + +P++ Sbjct: 196 LKVWN--TNFQIRYTFKAHESNVNHLSISPNGKYIATGGKDKKLLIWDILNL--TYPQRE 251 Query: 377 FKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNT 414 F S+ +AF+ ++ + + + ++ T Sbjct: 252 FDAGST---INQIAFNPKLQW-VAVGTDQGVKIFNLMT 285 Score = 139 bits (349), Expect = 3e-33, Method: Composition-based stats. Identities = 45/280 (16%), Positives = 100/280 (35%), Gaps = 38/280 (13%) Query: 201 DFQGHNKPIKALRF------TEDCQSFLSSSFDRSVKIW-------DTETGKVKTRLHLN 247 +GH+ + ++ ED +S S D++V IW + G L + Sbjct: 16 ILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKALTGH 75 Query: 248 STPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSK 307 + + I + + +D R + H S + ++ + PD + Sbjct: 76 NHFVSDLALSQENCFAISSSWDKTLRLWDLRTGTTYK---RFVGHQSEVYSVAFSPDNRQ 132 Query: 308 FISSSEDKTVRIWENQINVPIKQISDTAQHS--MPFLNVHP----------SQNYFCAQS 355 +S+ ++ +++W + ++ HS + + P YF + Sbjct: 133 ILSAGAEREIKLWNI-LGECKFSSAEKENHSDWVSCVRYSPIMKSANKVQPFAPYFASVG 191 Query: 356 MDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTS 415 D R+ ++ + + FK H S +S+ S +G+YI +G +L WD Sbjct: 192 WDGRLKVWNTNFQIRY----TFKAHESNVNHLSI--SPNGKYIATGGKDKKLLIWDILNL 245 Query: 416 RLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 + I Q+ ++P+ + + G + + + Sbjct: 246 TYPQR-EFDAGSTINQIAFNPK--LQWVAVGTDQGVKIFN 282 >5GAN-H nrPDB Length = 465 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 42/214 (19%), Positives = 90/214 (42%), Gaps = 6/214 (2%) Query: 153 KVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKAL 212 +++ + GH + +K+ P +G I S +D T ++WD E L +GH+K + +L Sbjct: 256 RLLGDLVGHERRISDVKYHP-SGKFIGSASHDMTWRLWDASTHQELLLQ-EGHDKGVFSL 313 Query: 213 RFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKI 272 F D S D +WD +G L +S P + N ++ G + I Sbjct: 314 SFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGHSKPIYTVAWSPNGYQVATGGGDGII 373 Query: 273 LHYDDRVSENQGLVQTYDHHLSSILALKYFPD--GSKFISSSEDKTVRIWENQINVPIKQ 330 +D R + L Q H + + +++ + G K +S D + ++ + + + Sbjct: 374 NVWDIRKRDEGQLNQIL-AHRNIVTQVRFSKEDGGKKLVSCGYDNLINVYSSDTWLKMGS 432 Query: 331 ISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFS 364 ++ + L++ + ++ + D I ++ Sbjct: 433 LA-GHTDKIISLDISNNSHFLVSGGWDRSIKLWN 465 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 54/351 (15%), Positives = 114/351 (32%), Gaps = 29/351 (8%) Query: 79 TSQASETQKEDQDIFVHALAEDNLDS--------EQIEVEEVSHFYGKSEKDYQGRGYLY 130 ++K Q + +++ E++ S K Sbjct: 126 NYSLERSRKRLQKEMERHQKFNTRQELLSRRTELQRMANLELAGSQLVSTKPISAVS--L 183 Query: 131 PPNDVDVDLREERISFRCYLPKKVI---RNYPGHPEGTTALKFLPKTGHLILSGGNDHTI 187 +D+ V + + + + H A+ + P + + ++S D I Sbjct: 184 STDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDGLI 243 Query: 188 KIWDFYH---DYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRL 244 K + + + L D GH + I +++ + S+S D + ++WD T + Sbjct: 244 KNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQELLLQ 303 Query: 245 HLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPD 304 + S + G +S + +D R V T H I + + P+ Sbjct: 304 EGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSK---VMTLAGHSKPIYTVAWSPN 360 Query: 305 GSKFISSSEDKTVRIWENQI--NVPIKQISDTAQHSMPFLNVHPS--QNYFCAQSMDNRI 360 G + + D + +W+ + + QI ++ + + + DN I Sbjct: 361 GYQVATGGGDGIINVWDIRKRDEGQLNQILA-HRNIVTQVRFSKEDGGKKLVSCGYDNLI 419 Query: 361 YSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWD 411 +S K GH+ ISL S + ++ SG + W+ Sbjct: 420 NVYSSDTWLK---MGSLAGHTDK--IISLDISNNSHFLVSGGWDRSIKLWN 465 Score = 135 bits (339), Expect = 5e-32, Method: Composition-based stats. Identities = 50/213 (23%), Positives = 84/213 (39%), Gaps = 13/213 (6%) Query: 247 NSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPD-G 305 ++ P S T+ G + + + Q L Q D H+ I A+ + PD Sbjct: 174 STKPISAVSLSTDDMVVATGSWAGDLQVLNSQTL--QPLTQKLDSHVGKIGAIDWHPDSN 231 Query: 306 SKFISSSEDKTVRIWENQINVP-IKQISDTAQHSMPF--LNVHPSQNYFCAQSMDNRIYS 362 ++ IS +ED ++ ++ ++ + D H + HPS + + S D + Sbjct: 232 NQMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHD---MT 288 Query: 363 FSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIK 422 + L + +GH + SL+F DG +CSG S WD + + + Sbjct: 289 WRLWDASTHQELLLQEGHDKGVF--SLSFQCDGSLVCSGGMDSLSMLWDIRSGSKVMTLA 346 Query: 423 IPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 +KPI V W P +V G G I V D Sbjct: 347 GH-SKPIYTVAWSPN-GYQVATGGGDGIINVWD 377 Score = 130 bits (326), Expect = 1e-30, Method: Composition-based stats. Identities = 48/254 (18%), Positives = 101/254 (39%), Gaps = 11/254 (4%) Query: 206 NKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRL--HLNSTPADVESRPTNPHEF 263 KPI A+ + D + S+ +++ +++T + T+ ++ P + ++ Sbjct: 175 TKPISAVSLSTDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQM 234 Query: 264 IVGLSNSKILHYDDRVSEN-QGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWEN 322 I + I ++ E L+ H I +KY P G S+S D T R+W+ Sbjct: 235 ISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDA 294 Query: 323 QINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSS 382 + + + + + L+ + C+ MD+ + ++ K GHS Sbjct: 295 STHQEL-LLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRSGSK---VMTLAGHSK 350 Query: 383 AGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKP-ITQVDWHPQETS- 440 Y ++A+S +G + +G + WD +I ++ +TQV + ++ Sbjct: 351 PIY--TVAWSPNGYQVATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDGGK 408 Query: 441 KVICSGAAGKIYVC 454 K++ G I V Sbjct: 409 KLVSCGYDNLINVY 422 >4LG8-A nrPDB Length = 354 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 54/248 (21%), Positives = 100/248 (40%), Gaps = 11/248 (4%) Query: 209 IKALRFTE-DCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGL 267 I AL D L+ D++V ++D + ++ L ++ + Sbjct: 74 ILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSAS 133 Query: 268 SNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVP 327 ++ I + N VQ H S++ L G +SSS+D+ + Q Sbjct: 134 PDATIRIW---SVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRV 190 Query: 328 IKQISD-TAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYG 386 + +++D T+ S+ HP F +MD++I + LK R F GHS G Sbjct: 191 LTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKE---RTNVANFPGHS--GPI 245 Query: 387 ISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSG 446 S+AFS +G Y+ + S + WD + +++ N + + + Q + + G Sbjct: 246 TSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFD-QSGTYLALGG 304 Query: 447 AAGKIYVC 454 +IY+C Sbjct: 305 TDVQIYIC 312 Score = 159 bits (401), Expect = 3e-39, Method: Composition-based stats. Identities = 62/342 (18%), Positives = 125/342 (36%), Gaps = 21/342 (6%) Query: 77 DETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYL----YPP 132 D+ + + +KE L + E + +V+ G G L Sbjct: 28 DKATVLTTERKERGKTVPEELVK---PEELSKYRQVASHVGLHSASIPGILALDLCPSDT 84 Query: 133 NDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF 192 N + ++ + ++++ GH + T++ F P + L+ S D TI+IW Sbjct: 85 NKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHP-SQDLVFSASPDATIRIWSV 143 Query: 193 YHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPAD 252 + C++ + H + L LSSS D+ D +TG+V T++ ++ Sbjct: 144 -PNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCS 202 Query: 253 VESRPTNPHEFIVGLS--NSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFIS 310 + +P I G +S+I +D + N V + H I ++ + +G + Sbjct: 203 LTCAQFHPDGLIFGTGTMDSQIKIWDLKERTN---VANFPGHSGPITSIAFSENGYYLAT 259 Query: 311 SSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYK 370 +++D +V++W+ + K + + L S Y D +IY + Sbjct: 260 AADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEIL 319 Query: 371 RHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDW 412 +G +AF ++I S L + Sbjct: 320 HFT-------EHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL 354 Score = 124 bits (310), Expect = 1e-28, Method: Composition-based stats. Identities = 35/201 (17%), Positives = 77/201 (38%), Gaps = 11/201 (5%) Query: 256 RPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDK 315 P++ ++ + G ++ ++ +D + ++ T H + ++ + P S+S D Sbjct: 80 CPSDTNKILTGGADKNVVVFDKSSEQ---ILATLKGHTKKVTSVVFHPSQDLVFSASPDA 136 Query: 316 TVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKK 375 T+RIW N Q+ + ++ L++H + +Y + S D ++ Sbjct: 137 TIRIWSVP-NASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQY---WAFSDIQTGRVLT 192 Query: 376 IFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNK-PITQVDW 434 +S F DG +G S++ WD + N PG+ PIT + + Sbjct: 193 KVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANF--PGHSGPITSIAF 250 Query: 435 HPQETSKVICSGAAGKIYVCD 455 + + + + D Sbjct: 251 SEN-GYYLATAADDSSVKLWD 270 >3JZG-A nrPDB Length = 402 Score = 161 bits (407), Expect = 6e-40, Method: Composition-based stats. Identities = 51/286 (17%), Positives = 107/286 (37%), Gaps = 37/286 (12%) Query: 144 ISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD--YECLRD 201 I + + I++Y GH LKF P+ +L+LS DH +++W+ D Sbjct: 133 IRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGG 192 Query: 202 FQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPH 261 +GH + + + + +S D S+K+W + + +N+ + P + Sbjct: 193 VEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINS-----KRMMNAIKESYDYNPNKTN 247 Query: 262 EFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321 + + +H+ D T D H + + +++ G +S S + + W+ Sbjct: 248 RPFIS----QKIHFPD--------FSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWK 293 Query: 322 -------------NQINVPIKQISDTAQHSMPFLNVHPS--QNYFCAQSMDNRIYSFSLK 366 ++ NV I D +Q + ++ Q + ++Y + L+ Sbjct: 294 PGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLE 353 Query: 367 PKYKRHPKKIFKGHSSAGYGI-SLAFSGDGRYICSGDSKSRLFTWD 411 + K H G I +FS D + + + ++ WD Sbjct: 354 VEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 399 Score = 45.2 bits (105), Expect = 6e-05, Method: Composition-based stats. Identities = 11/137 (8%), Positives = 47/137 (34%), Gaps = 9/137 (6%) Query: 327 PIKQISDTAQHSMPFLNV---HPSQNYFCAQSM-DNRIYSFSLKPKYKRHPKKIFKGHSS 382 + + + + + + ++ NR+ + + + + + + Sbjct: 45 CVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADA 104 Query: 383 AGYGISLAFSGDGRY----ICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQE 438 + A++ D + S+ + + T + + + GN I ++ +HP++ Sbjct: 105 DENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGN-AINELKFHPRD 163 Query: 439 TSKVICSGAAGKIYVCD 455 + ++ + + + Sbjct: 164 PNLLLSVSKDHALRLWN 180 >5UZ7-B nrPDB Length = 351 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 48/326 (14%), Positives = 107/326 (32%), Gaps = 16/326 (4%) Query: 134 DVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFY 193 D + I + + R GH A+ + + L++S D + IWD Y Sbjct: 38 DATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDS-RLLVSASQDGKLIIWDSY 96 Query: 194 HDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTR----LHLNST 249 + + + + + D I++ +T + R L ++ Sbjct: 97 TTNK-VHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTG 155 Query: 250 PADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFI 309 R + ++ + ++ +D E T+ H +++L PD F+ Sbjct: 156 YLSC-CRFLDDNQIVTSSGDTTCALWDI---ETGQQTTTFTGHTGDVMSLSLAPDTRLFV 211 Query: 310 SSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKY 369 S + D + ++W+ + + +Q + + + P+ N F S D F L+ Sbjct: 212 SGACDASAKLWDVREGMC-RQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQ 270 Query: 370 KRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPI 429 + + + S++FS GR + +G WD + + N+ Sbjct: 271 E---LMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNR-- 325 Query: 430 TQVDWHPQETSKVICSGAAGKIYVCD 455 + V + + + Sbjct: 326 VSCLGVTDDGMAVATGSWDSFLKIWN 351 >6N9G-C nrPDB Length = 353 Score = 158 bits (399), Expect = 5e-39, Method: Composition-based stats. Identities = 58/366 (15%), Positives = 123/366 (33%), Gaps = 22/366 (6%) Query: 97 LAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIR 156 +A D L + S K + R L+ DV++ ER+ K R Sbjct: 1 MATDGLHENETLASLKSEAESLKGKLEEERAKLH---DVELHQVAERVEALGQFVMKTRR 57 Query: 157 NYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTE 216 GH + + I+S D + +WD + + + A + Sbjct: 58 TLKGHGNKVLCMDWCKDKRR-IVSSSQDGKVIVWDSFTTNKEHAVTMPCT-WVMACAYAP 115 Query: 217 DCQSFLSSSFDRSVKIW------DTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNS 270 + D ++ + K + +++ S + + + + Sbjct: 116 SGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDG 175 Query: 271 KILHYDDRVSENQGLVQTYDHHLSSILALKYFPD--GSKFISSSEDKTVRIWENQINVPI 328 +D + L+Q++ H + +L L P G+ F+S DK +W+ + + Sbjct: 176 TCALWDVESGQ---LLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCV 232 Query: 329 KQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGIS 388 Q +T + + + +PS + F + S D + L+ I+ S S Sbjct: 233 -QAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDLR---ADREVAIYSKESIIFGASS 288 Query: 389 LAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAA 448 + FS GR + +G + + WD ++ + N+ ++ + P + Sbjct: 289 VDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENR-VSTLRVSPD-GTAFCSGSWD 346 Query: 449 GKIYVC 454 + V Sbjct: 347 HTLRVW 352 >6Q8F-A nrPDB Length = 514 Score = 158 bits (399), Expect = 5e-39, Method: Composition-based stats. Identities = 54/335 (16%), Positives = 120/335 (35%), Gaps = 23/335 (6%) Query: 91 DIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYL 150 D+F A +++ E+ + H + + + + + I + Sbjct: 186 DLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFT 245 Query: 151 PKKVIRNYPGHPE--------GTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDF 202 K+ ++ + + F + ++ +G D IK+W +CLR F Sbjct: 246 TGKIRKDLKYQAQDNFMMMDDAVLCMCFS-RDTEMLATGAQDGKIKVWKIQSG-QCLRRF 303 Query: 203 Q-GHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPH 261 + H+K + L F++D LS+SFD++++I ++GK +S+ + + + H Sbjct: 304 ERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGH 363 Query: 262 EFIVGLSNSKILHYDDRVSENQGLVQTY---DHHLSSILALKYFPDG-SKFISSSEDKTV 317 I S+ + ++ + +E ++ ++ ++ P F+ + TV Sbjct: 364 YIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTV 423 Query: 318 RIWENQINVPIKQISDTAQHSMPFL--NVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKK 375 I Q + ++ S + F+ + P + D +Y FS ++ Sbjct: 424 VIMNMQGQI-VRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFS---TVTGKLER 479 Query: 376 IFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTW 410 H I +A I + L W Sbjct: 480 TLTVHEKDV--IGIAHHPHQNLIATYSEDGLLKLW 512 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 44/229 (19%), Positives = 83/229 (36%), Gaps = 42/229 (18%) Query: 204 GHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEF 263 G ++ RF+ D Q ++ S D +++W+ TGK++ L + Sbjct: 213 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQ-------------- 258 Query: 264 IVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQ 323 + DD ++L + + D + ++D +++W+ Q Sbjct: 259 ------DNFMMMDD-----------------AVLCMCFSRDTEMLATGAQDGKIKVWKIQ 295 Query: 324 INVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSA 383 +++ + L+ + + S D I LK K F+GHSS Sbjct: 296 SGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLK---SGKTLKEFRGHSS- 351 Query: 384 GYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQV 432 + F+ DG YI S S + W+ T+ N K G+ T + Sbjct: 352 -FVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDI 399 Score = 77.5 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 17/120 (14%), Positives = 39/120 (32%), Gaps = 3/120 (2%) Query: 329 KQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSS---AGY 385 + I + + P Y S+D I ++ R K + Sbjct: 208 RHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDA 267 Query: 386 GISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICS 445 + + FS D + +G ++ W + + L + +K +T + + + + S Sbjct: 268 VLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSAS 327 Score = 56.0 bits (133), Expect = 4e-08, Method: Composition-based stats. Identities = 14/103 (13%), Positives = 32/103 (31%), Gaps = 6/103 (5%) Query: 358 NRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRL 417 + ++ + + FS DG+Y+ +G + W++ T ++ Sbjct: 190 GKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKI 249 Query: 418 LNNIKIPGN------KPITQVDWHPQETSKVICSGAAGKIYVC 454 ++K ++T + GKI V Sbjct: 250 RKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVW 292 Score = 37.1 bits (84), Expect = 0.016, Method: Composition-based stats. Identities = 9/42 (21%), Positives = 17/42 (40%), Gaps = 1/42 (2%) Query: 150 LPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWD 191 + K+ R H + + P +LI + D +K+W Sbjct: 473 VTGKLERTLTVHEKDVIGIAHHPHQ-NLIATYSEDGLLKLWK 513 >6EMK-B nrPDB Length = 303 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 55/295 (18%), Positives = 113/295 (38%), Gaps = 15/295 (5%) Query: 141 EERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF-YHDYECL 199 + I F L R L+ L+ + G+ + ++++D + + Sbjct: 11 DHTIRFWEALTGVCSRTIQHSDSQVNRLEITNDK-KLLATAGHQN-VRLYDIRTTNPNPV 68 Query: 200 RDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTN 259 F+GH + ++ F +D + ++SS D ++K+WD + + R + ++ P + N Sbjct: 69 ASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSI-PRNYKHNAPVNEVVIHPN 127 Query: 260 PHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRI 319 E I + I +D ENQ Q +S+ +L DGS +++ + Sbjct: 128 QGELISCDRDGNIRIWDL--GENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTKGNCYV 185 Query: 320 WENQI---NVPIKQISDTAQHS--MPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPK 374 WE +K ++ HS + + + + S D+ +S+ +K + Sbjct: 186 WEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDFKL--E 243 Query: 375 KIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPI 429 GH + AFS D Y+ + S + WD +T ++ + Sbjct: 244 TTLDGH--QRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAV 296 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 43/236 (18%), Positives = 98/236 (41%), Gaps = 17/236 (7%) Query: 221 FLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVS 280 +S+ +D +++ W+ TG + + + + TN + + + + YD R + Sbjct: 5 LVSAGYDHTIRFWEALTGVCSRTIQHSDSQVN-RLEITNDKKLLATAGHQNVRLYDIRTT 63 Query: 281 ENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMP 340 N V +++ H ++ ++ + D ++SSED T+++W+ + I +H+ P Sbjct: 64 -NPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSP----SIPRNYKHNAP 118 Query: 341 F--LNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYI 398 + +HP+Q + D I + L H SL+ + DG + Sbjct: 119 VNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTP----EDDTSLQSLSMASDGSML 174 Query: 399 CSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVC 454 + ++K + W+ + N+ KP+T+ H ++++ S + C Sbjct: 175 AAANTKGNCYVWE-----MPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATC 225 Score = 144 bits (362), Expect = 1e-34, Method: Composition-based stats. Identities = 46/284 (16%), Positives = 98/284 (34%), Gaps = 14/284 (4%) Query: 177 LILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTE 236 +++S G DHTI+ W+ C R Q + + L T D + ++ ++V+++D Sbjct: 4 ILVSAGYDHTIRFWEALTGV-CSRTIQHSDSQVNRLEITNDKKLLATAGH-QNVRLYDIR 61 Query: 237 T--GKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLS 294 T + S + + + I +D R + H + Sbjct: 62 TTNPNPVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPS----IPRNYKHNA 117 Query: 295 SILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQ 354 + + P+ + IS D +RIW+ N Q++ S+ L++ + A Sbjct: 118 PVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAA 177 Query: 355 SMDNRIYSFSL---KPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWD 411 + Y + + P F+ HS+ Y + S D +++ + + W Sbjct: 178 NTKGNCYVWEMPNHTDASHLKPVTKFRAHST--YITRILLSSDVKHLATCSADHTARVWS 235 Query: 412 WNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 + L + + + V S + + + D Sbjct: 236 IDDDFKLETTLDGHQRWVWDCAFSADSAYLVTAS-SDHYVRLWD 278 Score = 77.2 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 21/117 (17%), Positives = 44/117 (37%), Gaps = 1/117 (0%) Query: 142 ERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRD 201 E + K + + H T + H + + DHT ++W D++ Sbjct: 187 EMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKH-LATCSADHTARVWSIDDDFKLETT 245 Query: 202 FQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPT 258 GH + + F+ D +++S D V++WD T ++ + + A + Sbjct: 246 LDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREIVRQYGGHHKGAVCVALND 302 >5FVM-C nrPDB Length = 303 Score = 155 bits (392), Expect = 3e-38, Method: Composition-based stats. Identities = 49/295 (16%), Positives = 108/295 (36%), Gaps = 15/295 (5%) Query: 141 EERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF-YHDYECL 199 + I F L R L+ + + G+ ++++D ++ + Sbjct: 11 DHTIRFWEALTGVCSRTIQHADSQVNRLEITSDK-KYLAAAGH-LHVRLYDIRSNNPNPV 68 Query: 200 RDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTN 259 F+GH + ++ F ++ + +SSS D ++K+WD + R + ++ P + + N Sbjct: 69 SSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRS-PSVQRNYKHNAPVNEVAIHPN 127 Query: 260 PHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRI 319 E I + I +D ENQ Q + + +L DGS ++ + + Sbjct: 128 QGELISCDQDGNIRIWDL--GENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNKGNCYV 185 Query: 320 WENQINVPIKQI-----SDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPK 374 W + + + + + + S D+ ++++ Y+ + Sbjct: 186 WRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNIEDNYQL--E 243 Query: 375 KIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPI 429 GH + AFS D Y+ + S + WD +TS ++ + Sbjct: 244 TTLDGH--QRWVWDCAFSADSAYLVTACSDHYVRLWDLSTSEIVRQYGGHHKGAV 296 Score = 147 bits (370), Expect = 1e-35, Method: Composition-based stats. Identities = 47/284 (16%), Positives = 94/284 (33%), Gaps = 14/284 (4%) Query: 177 LILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTE 236 ++ S G DHTI+ W+ C R Q + + L T D + ++ V+++D Sbjct: 4 ILASAGYDHTIRFWEALTGV-CSRTIQHADSQVNRLEITSDKKYLAAAGH-LHVRLYDIR 61 Query: 237 TGKVKTRLHLNSTPADVESRPTNP--HEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLS 294 + +V S + + I +D R VQ H + Sbjct: 62 SNNPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPS----VQRNYKHNA 117 Query: 295 SILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQ 354 + + P+ + IS +D +RIW+ N Q++ + L+V + A Sbjct: 118 PVNEVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAG 177 Query: 355 SMDNRIYSFSL---KPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWD 411 + Y + + P FK H+ Y + S D + + + + W+ Sbjct: 178 NNKGNCYVWRMPHHTDASTLEPVTKFKSHTK--YITRVLLSADVKNLATCSADHTARVWN 235 Query: 412 WNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 + L + + + V + + + D Sbjct: 236 IEDNYQLETTLDGHQRWVWDCAFSADSAYLVTAC-SDHYVRLWD 278 Score = 79.1 bits (193), Expect = 3e-15, Method: Composition-based stats. Identities = 25/195 (12%), Positives = 66/195 (33%), Gaps = 11/195 (5%) Query: 261 HEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 + + + + ++ +T H S + L+ D ++ VR++ Sbjct: 2 SVILASAGYDHTIRFWEALTG--VCSRTIQHADSQVNRLEITSDKKYLAAAGH-LHVRLY 58 Query: 321 ENQINVPIK-QISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKG 379 + + N P + + ++ + + + S D I + ++ + K Sbjct: 59 DIRSNNPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYK---- 114 Query: 380 HSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQET 439 H++ +++ + + S D + WD ++ N + N P+ + Sbjct: 115 HNAPVNEVAIHPNQGE--LISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASD-G 171 Query: 440 SKVICSGAAGKIYVC 454 S ++ G YV Sbjct: 172 SMLVAGNNKGNCYVW 186 Score = 79.1 bits (193), Expect = 3e-15, Method: Composition-based stats. Identities = 18/116 (15%), Positives = 43/116 (37%), Gaps = 1/116 (0%) Query: 143 RISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDF 202 + + + H + T + L + + DHT ++W+ +Y+ Sbjct: 188 MPHHTDASTLEPVTKFKSHTKYITRV-LLSADVKNLATCSADHTARVWNIEDNYQLETTL 246 Query: 203 QGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPT 258 GH + + F+ D +++ D V++WD T ++ + + A + Sbjct: 247 DGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLSTSEIVRQYGGHHKGAVCVALND 302 >6E29-D nrPDB Length = 345 Score = 154 bits (389), Expect = 7e-38, Method: Composition-based stats. Identities = 64/325 (19%), Positives = 115/325 (35%), Gaps = 36/325 (11%) Query: 159 PGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDC 218 GH T ++F + G + SG D T+ IWD R +GH+K I +L ++ Sbjct: 25 SGHS---TCVRFN-RKGDFLASGRVDGTVVIWDLET-MGVARKLRGHSKNITSLSWSRCG 79 Query: 219 QSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDR 278 + LS+ V +WD + GK + + E P N H+F L + + D Sbjct: 80 RYLLSACQGWKVILWDLQDGKRYREVRFRAPVYGAELHPWNHHQFAAALFEDQPMLVDIT 139 Query: 279 ----------------VSENQGLVQTYDHHLSS---ILALKYFPDGSKFISSSEDKTVRI 319 +E ++ + A+ Y G ++ + + I Sbjct: 140 EPVEVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGDHLLAGTTKGRLNI 199 Query: 320 WENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSF--------SLKPKYKR 371 + + I A + L + S + D I +F L P + Sbjct: 200 IDARTREIIYS-EKIASGIITTLRLTESGRELLVNAQDRIIRTFIVPNLSAADLDPDTIQ 258 Query: 372 HPKK-IFKGHSSAGYGISLAFSGDGRYIC-SGDSKSRLFTWDWNTSRLLNNIKIPGNKPI 429 P + F+ + +AFS G Y+ S + L+ W+ L+ ++ P + Sbjct: 259 LPLEHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIWERGHGSLVRMLEGP-KEEQ 317 Query: 430 TQVDWHPQETSKVICSGAAGKIYVC 454 ++WHP C G+I + Sbjct: 318 GVIEWHPHRALLAACGLETGRINIW 342 >6GMH-W nrPDB Length = 305 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 51/306 (16%), Positives = 113/306 (36%), Gaps = 15/306 (4%) Query: 154 VIRNYPGHPEGTTALKF---LPKTGHLILSGGNDHTIKIWDFYHDY-ECLRDFQGHNKPI 209 + + H + ++ + + +++G D +K+W + + + +GH + Sbjct: 8 LFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGV 67 Query: 210 KALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSN 269 ++ + SSS D +++WD E GK + A + + G Sbjct: 68 VSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHV 127 Query: 270 SKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIK 329 K+ + + + + D IL++ Y PDG S + D + I++ + Sbjct: 128 GKVNIFGVESGKKEY---SLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLH 184 Query: 330 QISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISL 389 + + + L P S D I + ++ + GH+S + +++ Sbjct: 185 TL-EGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQ---HANLAGTLSGHAS--WVLNV 238 Query: 390 AFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAG 449 AF D + S S + WD T ++ + V ++ SK++ G Sbjct: 239 AFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF-FDHQDQVWGVKYNGN-GSKIVSVGDDQ 296 Query: 450 KIYVCD 455 +I++ D Sbjct: 297 EIHIYD 302 Score = 119 bits (297), Expect = 3e-27, Method: Composition-based stats. Identities = 42/164 (25%), Positives = 78/164 (47%), Gaps = 7/164 (4%) Query: 162 PEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSF 221 + ++ + P G + SG D I I+D + L +GH PI++L F+ D Q Sbjct: 148 GKFILSIAYSPD-GKYLASGAIDGIINIFDIATG-KLLHTLEGHAMPIRSLTFSPDSQLL 205 Query: 222 LSSSFDRSVKIWDTETGKVKTRLHLN-STPADVESRPTNPHEFIVGLSNSKILHYDDRVS 280 +++S D +KI+D + + L + S +V P + H F+ S+ + +D Sbjct: 206 VTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTH-FVSSSSDKSVKVWDV--- 261 Query: 281 ENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQI 324 + V T+ H + +KY +GSK +S +D+ + I++ I Sbjct: 262 GTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDCPI 305 Score = 77.5 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 32/126 (25%), Positives = 51/126 (40%), Gaps = 2/126 (1%) Query: 151 PKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIK 210 K++ GH +L F P + L+++ +D IKI+D H GH + Sbjct: 179 TGKLLHTLEGHAMPIRSLTFSPDS-QLLVTASDDGYIKIYDVQH-ANLAGTLSGHASWVL 236 Query: 211 ALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNS 270 + F D F+SSS D+SVK+WD T + N + + + Sbjct: 237 NVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQ 296 Query: 271 KILHYD 276 +I YD Sbjct: 297 EIHIYD 302 >5OV3-A nrPDB Length = 381 Score = 151 bits (382), Expect = 5e-37, Method: Composition-based stats. Identities = 61/316 (19%), Positives = 116/316 (36%), Gaps = 22/316 (6%) Query: 156 RNYPGHPEGTTAL------KFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPI 209 +NYP +GT + G L+ G ND I IWDF + H P+ Sbjct: 12 QNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLT-RGIAKIISAHIHPV 70 Query: 210 KALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSN 269 +L ++ D +S+S D V WD +G R S V+ P + ++ +V Sbjct: 71 CSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMK 130 Query: 270 SKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIK 329 S + S++ L D L+ + + + G + + + + + + Sbjct: 131 SAPVMLTLSDSKHVVLPVDDDSDLNVVAS--FDRRGEYIYTGNAKGKILVLKTDSQDLVA 188 Query: 330 QISDTAQHS----MPFLNVHPSQNYFCAQSMDNRIYSFSLKPKY------KRHPKKIFKG 379 T S + + + F + D I + + + P + + Sbjct: 189 SFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQD 248 Query: 380 HSSAGYGISLAFSGDGRYICSGDSKSR-LFTWDWNTSRLLNNIKIPGNKPITQVDWHPQE 438 + FSGDG YI +G ++ L+ W+ + L+ + + + V WHP Sbjct: 249 LVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHP-- 306 Query: 439 TSKVICSGAAGKIYVC 454 +I S ++G + + Sbjct: 307 VRPIIASISSGVVSIW 322 >6BX3-A nrPDB Length = 314 Score = 147 bits (371), Expect = 9e-36, Method: Composition-based stats. Identities = 57/267 (21%), Positives = 94/267 (35%), Gaps = 21/267 (7%) Query: 161 HPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQS 220 H + L + P G I + +D +++I + Y L F GH P+ +L F Sbjct: 53 HARPFSELCWSPD-GQCIATASDDFSVEI--IHLSYGLLHTFIGHTAPVISLTFNRKGNL 109 Query: 221 FLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVS 280 +SS D S+KIWDT G + + +S P N + S ++ D + Sbjct: 110 LFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAET 169 Query: 281 ENQGLVQTYD------HHLSSILALKYFPDGSKFISSSEDKTVRIWENQIN--------V 326 + TYD + + I +K+ + + S D V+IW+ Sbjct: 170 GHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQ 229 Query: 327 PIKQISDTAQHSMPFLNVHP-SQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGY 385 P+++ M FLN S + + IY ++ K H S+ Sbjct: 230 PLEKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPV 289 Query: 386 GISLAFSGDGRYICSGDSKSRLFTWDW 412 F G +CS W W Sbjct: 290 MSIHCF---GNIMCSLALNGDCCLWRW 313 Score = 121 bits (302), Expect = 8e-28, Method: Composition-based stats. Identities = 51/298 (17%), Positives = 106/298 (35%), Gaps = 22/298 (7%) Query: 166 TALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSS 225 T K P L ++ G I I+D H +P L ++ D Q ++S Sbjct: 16 TCAKISPDGQFLAITQGL--NILIYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATAS 73 Query: 226 FDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGL 285 D SV+I G + T + ++ P + + + I +D + N L Sbjct: 74 DDFSVEIIHLSYGLLHTFI-GHTAPVISLTFNRKGNLLFTSSMDESIKIWD---TLNGSL 129 Query: 286 VQTYDHHLSSILALKY-FPDGSKFISSSEDKTVRIWENQINVPIKQIS-------DTAQH 337 ++T H +++++ D S S S D +RI++ + +K ++ + Sbjct: 130 MKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVV 189 Query: 338 SMPFLNVHPSQNYFCAQSMDNRIYSFS-----LKPKYKRHPKKIFKGHSSAGYGISLAFS 392 + + + Y +S+D + + + ++ P + H S G Sbjct: 190 PISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPED 249 Query: 393 GDGRYICSGDSKSRLFTWDWNTSRLLNNIKI---PGNKPITQVDWHPQETSKVICSGA 447 G + SG ++ W+ +T LL + + P+ + + +G Sbjct: 250 GSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHCFGNIMCSLALNGD 307 Score = 83.3 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 40/204 (19%), Positives = 71/204 (34%), Gaps = 22/204 (10%) Query: 138 DLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYE 197 +E I L +++ H E ++ ++ SG D I+I+D + Sbjct: 113 SSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSILSSGSYDGLIRIFDAETGH- 171 Query: 198 CLRDFQGHNK--------PIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNST 249 CL+ PI ++F+E+ + L S D VKIWD G V + Sbjct: 172 CLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPL 231 Query: 250 PADVESRP----------TNPHEFIVGLSNSKILHYDDRVSENQGLVQ-TYDHHLSSILA 298 V + I G N I ++ L+ + HH S +++ Sbjct: 232 EKGVLHHSCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMS 291 Query: 299 LKYFPDGSKFISSSEDKTVRIWEN 322 + F G+ S + + +W Sbjct: 292 IHCF--GNIMCSLALNGDCCLWRW 313 >5LCW-Q nrPDB Length = 374 Score = 146 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 43/250 (17%), Positives = 92/250 (36%), Gaps = 15/250 (6%) Query: 103 DSEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHP 162 D +Q + + Y+ + + + + GH Sbjct: 129 DVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEH----HVATLSGHS 184 Query: 163 EGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD---YECLRDFQGHNKPIKALRFTEDCQ 219 + L++ P H + SGGND+ + +W + L+ F H +KA+ + Sbjct: 185 QEVCGLRWAPDGRH-LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQS 243 Query: 220 SFLS---SSFDRSVKIWDTETGKVKTRLHLNSTPADVESRP-TNPHEFIVGLSNSKILHY 275 + L+ + DR ++IW+ +G + + +S + P G + ++++ + Sbjct: 244 NVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIW 303 Query: 276 DDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTA 335 V H S +L+L PDG+ S++ D+T+R+W P ++ Sbjct: 304 K---YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREK 360 Query: 336 QHSMPFLNVH 345 + +H Sbjct: 361 ASAAKSSLIH 370 Score = 143 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 59/353 (16%), Positives = 120/353 (33%), Gaps = 55/353 (15%) Query: 105 EQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPG-HPE 163 E+ ++ +S + + YQ R + + + LP +++ + Sbjct: 1 EEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDY 60 Query: 164 GTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHN--KPIKALRFTEDCQSF 221 + + +G+++ D+++ +W + L+ Q + I ++ + ++ Sbjct: 61 YLNLVDWS--SGNVLAVA-LDNSVYLWSASSG-DILQLLQMEQPGEYISSVAWIKEGNYL 116 Query: 222 LSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSE 281 + V++WD + K ++ S A V S N + G + I H+D RV+E Sbjct: 117 AVGTSSAEVQLWDV--QQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAE 174 Query: 282 NQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWEN---QINVPIKQISDTAQHS 338 + V T H + L++ PDG S D V +W + + Q Q + Sbjct: 175 HH--VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGA 232 Query: 339 MPFLNVHPSQNYFCA---QSMDNRIYSFSLKPKYKRHP----------------KKIFKG 379 + + P Q+ A + D I +++ K++ G Sbjct: 233 VKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISG 292 Query: 380 HSSAGY----------------------GISLAFSGDGRYICSGDSKSRLFTW 410 H A +SL S DG + S + L W Sbjct: 293 HGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 345 Score = 86.8 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 26/203 (12%), Positives = 69/203 (33%), Gaps = 13/203 (6%) Query: 258 TNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTV 317 + + ++ + + + L+Q I ++ + +G+ + V Sbjct: 67 WSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGE-YISSVAWIKEGNYLAVGTSSAEV 125 Query: 318 RIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIF 377 ++W+ Q ++ ++ HS ++ + + S I+ ++ Sbjct: 126 QLWDVQQQKRLRNMTS---HSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHH--VATL 180 Query: 378 KGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSR---LLNNIKIPGNKPITQVDW 434 GHS L ++ DGR++ SG + + + W + + V W Sbjct: 181 SGHSQEV--CGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAW 238 Query: 435 HPQETSKVICSGA--AGKIYVCD 455 P +++ + G I + + Sbjct: 239 CPWQSNVLATGGGTSDRHIRIWN 261 >5WYJ-BC nrPDB Length = 817 Score = 145 bits (366), Expect = 3e-35, Method: Composition-based stats. Identities = 39/223 (17%), Positives = 82/223 (36%), Gaps = 17/223 (7%) Query: 154 VIRNYPGHPEGTTALK----FLPKTGHLILSGGNDHTIKIWDFYH-----DYECLR---- 200 + Y GH TA+ +L+ ND TIK W D + ++ Sbjct: 426 IYAKYIGHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEY 485 Query: 201 DFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNP 260 H K I AL + + F ++S+D++ KIW+ E G+++ L + S Sbjct: 486 TRHAHEKDINALSVSPNDSIFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQYD 545 Query: 261 HEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 + + + + +++T + H +++ + + IS D ++IW Sbjct: 546 KLLATSSGDKTVKIW---SLDTFSVMKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIW 602 Query: 321 ENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSF 363 + +K + D + + L+ + + D + Sbjct: 603 DCSSGECLKTL-DGHNNRLWALSTMNDGDMIVSADADGVFQFW 644 Score = 137 bits (345), Expect = 8e-33, Method: Composition-based stats. Identities = 57/340 (16%), Positives = 119/340 (35%), Gaps = 37/340 (10%) Query: 66 DGPWGSWSSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQG 125 DG W + +S D+ ++ + D + + + Sbjct: 399 DGLWIATASKDNTAI-----------VWRYNENSCKFDIYAKYIGHSAAVTAVGLPNIVS 447 Query: 126 RGY----LYPPNDVDVDLREERISFRCYLPK--KVIR----NYPGHPEGTTALKFLPKTG 175 +GY L ND+ + ++ I + ++I+ H + AL P Sbjct: 448 KGYPEFLLTASNDLTI---KKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSP-ND 503 Query: 176 HLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDT 235 + + D T KIW+ + E H + + + F + + +SS D++VKIW Sbjct: 504 SIFATASYDKTCKIWNL-ENGELEATLANHKRGLWDVSFCQYDKLLATSSGDKTVKIWSL 562 Query: 236 ETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSS 295 +T V L ++ S + I ++ I +D E ++T D H + Sbjct: 563 DTFSVMKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWDCSSGE---CLKTLDGHNNR 619 Query: 296 ILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFL----NVHPSQNY- 350 + AL DG +S+ D + W++ I++ + A+ + N ++ Sbjct: 620 LWALSTMNDGDMIVSADADGVFQFWKDCTEQEIEEEQEKAKLQVEQEQSLQNYMSKGDWT 679 Query: 351 ---FCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGI 387 A ++D+ + F++ + + I Sbjct: 680 NAFLLAMTLDHPMRLFNVLKRALGESRSRQDTEEGKIEVI 719 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 46/272 (16%), Positives = 93/272 (34%), Gaps = 28/272 (10%) Query: 201 DFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLH----LNSTPADVESR 256 ++GH + +L TED ++S D + +W K ++ +S Sbjct: 383 IYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGL 442 Query: 257 PT-----NPHEFIVGLSNSKILHYDDRVSENQGLVQ-------TYDHHLSSILALKYFPD 304 P P + ++ I + VQ T H I AL P+ Sbjct: 443 PNIVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPN 502 Query: 305 GSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFS 364 S F ++S DKT +IW + ++ + + ++ S D + +S Sbjct: 503 DSIFATASYDKTCKIWNLENGELEATLA-NHKRGLWDVSFCQYDKLLATSSGDKTVKIWS 561 Query: 365 LKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIP 424 L K +GH++A +F + + S + + WD ++ L + Sbjct: 562 LDTFSV---MKTLEGHTNAVQ--RCSFINKQKQLISCGADGLIKIWDCSSGECLKTLDGH 616 Query: 425 GNK--PITQVDWHPQETSKVICSGAAGKIYVC 454 N+ ++ + + ++ + A G Sbjct: 617 NNRLWALSTM----NDGDMIVSADADGVFQFW 644 Score = 107 bits (266), Expect = 1e-23, Method: Composition-based stats. Identities = 56/408 (13%), Positives = 116/408 (28%), Gaps = 89/408 (21%) Query: 128 YLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFL--PKTGH---LILSGG 182 +L D + ++ + + +K + H L + P +LSGG Sbjct: 161 WLLASGDTNGMVKVWDL-----VKRKCLHTLQEHTSAVRGLDIIEVPDNDEPSLNLLSGG 215 Query: 183 NDHTIKIWDFYHDYECLRDFQG-HNKPIKALRFTEDC---QSFLSSSFDRSVKIWDTETG 238 D I +WDF +C N+ +++ F +D + ++ D ++ D+E+G Sbjct: 216 RDDIINLWDFNMKKKCKLLKTLPVNQQVESCGFLKDGDGKRIIYTAGGDAIFQLIDSESG 275 Query: 239 ---------------------------------------KVKTRLHLNSTPADVESRPTN 259 V+ L + V S Sbjct: 276 SVLKRTNKPIEELFIIGVLPILSNSQMFLVLSDQTLQLINVEEDLKNDEDTIQVTSSIAG 335 Query: 260 PHEFI----------------VGLSNSKILHYDDRVSENQGL---VQTYDHHLSSILALK 300 H I + +I+ D L V+ Y+ H + +L Sbjct: 336 NHGIIADMRYVGPELNKLALATNSPSLRIIPVPDLSGPEASLPLDVEIYEGHEDLLNSLD 395 Query: 301 YFPDGSKFISSSEDKTVRIWENQINVPIKQISD---TAQHSMPFLNVHPS------QNYF 351 DG ++S+D T +W N I ++ + + P+ + Sbjct: 396 ATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGL-PNIVSKGYPEFL 454 Query: 352 CAQSMDNRIYSF-----SLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSR 406 S D I + + + + H+ +L+ S + + Sbjct: 455 LTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDSIFATASYDKT 514 Query: 407 LFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVC 454 W+ L + + + V + Q + S + + Sbjct: 515 CKIWNLENGELEATL-ANHKRGLWDVSF-CQYDKLLATSSGDKTVKIW 560 Score = 90.3 bits (222), Expect = 1e-18, Method: Composition-based stats. Identities = 27/226 (11%), Positives = 77/226 (34%), Gaps = 24/226 (10%) Query: 246 LNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQ-GLVQTYDHHLSSILALKYFPD 304 + + + ++ + + + + + Y H +++ A+ P+ Sbjct: 386 GHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGHSAAVTAVGL-PN 444 Query: 305 G------SKFISSSEDKTVRIW---------ENQINVPIKQISDTAQHSMPFLNVHPSQN 349 +++S D T++ W + QI + + + L+V P+ + Sbjct: 445 IVSKGYPEFLLTASNDLTIKKWIIPKPTASMDVQIIKVSEYTRHAHEKDINALSVSPNDS 504 Query: 350 YFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFT 409 F S D ++L+ + ++F + + + + Sbjct: 505 IFATASYDKTCKIWNLENGELEATLA-----NHKRGLWDVSFCQYDKLLATSSGDKTVKI 559 Query: 410 WDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 W +T ++ ++ N + + + ++ ++I GA G I + D Sbjct: 560 WSLDTFSVMKTLEGHTN-AVQRCSFINKQ-KQLISCGADGLIKIWD 603 Score = 82.6 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 55/333 (16%), Positives = 96/333 (28%), Gaps = 34/333 (10%) Query: 154 VIRNYPGHPEGTTALKF---LPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIK 210 + ++ GH ++LKF L L+ SG + +K+WD +CL Q H ++ Sbjct: 136 ITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVK-RKCLHTLQEHTSAVR 194 Query: 211 ALRFT--EDCQ----SFLSSSFDRSVKIWDTETGKVKTRLHL---NSTPADVESRPTNPH 261 L D + LS D + +WD K L N Sbjct: 195 GLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLLKTLPVNQQVESCGFLKDGDG 254 Query: 262 EFIV--GLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRI 319 + I+ ++ D L I L + F+ S D+T+++ Sbjct: 255 KRIIYTAGGDAIFQLIDSESGSVLKRTNKPIEELFIIGVLPILSNSQMFLVLS-DQTLQL 313 Query: 320 W--------ENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSF---SLKPK 368 + I+ V P N + + L Sbjct: 314 INVEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGPELNKLALATNSPSLRIIPVPDLSGP 373 Query: 369 YKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNI--KIPGN 426 P + SL + DG +I + + W +N + +I K G+ Sbjct: 374 EASLPLDVEIYEGHEDLLNSLDATEDGLWIATASKDNTAIVWRYNENSCKFDIYAKYIGH 433 Query: 427 KPITQVDWHPQETSK-----VICSGAAGKIYVC 454 P SK ++ + I Sbjct: 434 SAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKW 466 Score = 79.5 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 50/274 (18%), Positives = 100/274 (36%), Gaps = 24/274 (8%) Query: 166 TALKFLPKTGHLILSGGNDHTIKIWDFYHDYECL--RDFQGHNKPIKALRFTEDCQSFLS 223 +A+ + + G ++ + D I I D + + + I AL+ T D Q Sbjct: 20 SAVATVSENGKILATPVLDE-INIIDLTPGSRKILHKISNEDEQEITALKLTPDGQYLTY 78 Query: 224 SSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQ 283 S + +KI+ +TGKV + ++S P+ + + VG ++ I+ D EN Sbjct: 79 VSQAQLLKIFHLKTGKVVRSMKISS-PSYILDADSTSTLLAVGGTDGSIIVVDI---ENG 134 Query: 284 GLVQTYDHHLSSILALKY----FPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSM 339 + ++ H +I +LK+ S + V++W+ + + + ++ Sbjct: 135 YITHSFKGHGGTISSLKFYGQLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQE-HTSAV 193 Query: 340 PFLNVH--PSQNY----FCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSG 393 L++ P + + D+ I + K K K + S F Sbjct: 194 RGLDIIEVPDNDEPSLNLLSGGRDDIINLWDFNMKKKCKLLKTLPVNQQ---VESCGFLK 250 Query: 394 DG---RYICSGDSKSRLFTWDWNTSRLLNNIKIP 424 DG R I + + D + +L P Sbjct: 251 DGDGKRIIYTAGGDAIFQLIDSESGSVLKRTNKP 284 Score = 47.5 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 23/136 (16%), Positives = 46/136 (33%), Gaps = 6/136 (4%) Query: 320 WENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKG 379 + + + ++ S V + +D I L P ++ KI Sbjct: 1 MDLKTSYKGISLNPIYAGSSAVATVSENGKILATPVLD-EINIIDLTPGSRKILHKI--S 57 Query: 380 HSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQET 439 + +L + DG+Y+ L + T +++ ++KI I D + Sbjct: 58 NEDEQEITALKLTPDGQYLTYVSQAQLLKIFHLKTGKVVRSMKISSPSYILDAD---STS 114 Query: 440 SKVICSGAAGKIYVCD 455 + + G G I V D Sbjct: 115 TLLAVGGTDGSIIVVD 130 >6CHG-A nrPDB Length = 312 Score = 145 bits (366), Expect = 4e-35, Method: Composition-based stats. Identities = 53/310 (17%), Positives = 96/310 (30%), Gaps = 48/310 (15%) Query: 151 PKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIK 210 K+++ H E L + P + I SG D T++I Y +R GH P+ Sbjct: 43 SSKMMKLTTTHKECINCLCWSPDS-KCIASGSEDFTVEITHII--YGRIRRLMGHTAPVI 99 Query: 211 ALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNS 270 ++ + SSS D S+K W +G + +S P + S Sbjct: 100 SICYNNKGNILCSSSMDESIKEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYD 159 Query: 271 KILHYDDRVSENQGLVQTYDHH------LSSILALKYFPDGSKFISSSEDKTVRIWENQI 324 ++ D S + TYD + I +K+ +G + S D V++WE Sbjct: 160 GLIRIFDTESGHCLKTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTR 219 Query: 325 NVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAG 384 ++ Q + L + Q D Sbjct: 220 GTVVRTFLWPHQETKAKLKYNCGLELIYPQGKD--------------------------- 252 Query: 385 YGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIK-IPGNKPITQVDWHPQETSKVI 443 + SG+ + W+ + L+ I N P+ + + + + Sbjct: 253 -----------PLVISGNDSGSMCVWNVYSKNLVQKIDEKHRNSPLISISASYDKVATLS 301 Query: 444 CSGAAGKIYV 453 +G V Sbjct: 302 LNGECNLFRV 311 Score = 98.0 bits (242), Expect = 7e-21, Method: Composition-based stats. Identities = 29/257 (11%), Positives = 87/257 (33%), Gaps = 16/257 (6%) Query: 210 KALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSN 269 + + + D + + + +++ + K+ + + + G + Sbjct: 17 TSCQISPDGELIAIC-QNTDMLVYEISSSKMMKLTTTHKECINCLCWSPDSKCIASGSED 75 Query: 270 SKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIK 329 + ++ H + ++++ Y G+ SSS D++++ W +K Sbjct: 76 FTVEITHIIYGR----IRRLMGHTAPVISICYNNKGNILCSSSMDESIKEWHVLSGTALK 131 Query: 330 QISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFK---GHSSAGYG 386 +S + + + + S D I F + + K Sbjct: 132 TMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWIAEDGVVPI 191 Query: 387 ISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDW-------HPQET 439 ++ FS +G+++ + + W++ ++ P + ++ + +PQ Sbjct: 192 STVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLKYNCGLELIYPQGK 251 Query: 440 SKVICSG-AAGKIYVCD 455 ++ SG +G + V + Sbjct: 252 DPLVISGNDSGSMCVWN 268 Score = 76.0 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 36/217 (16%), Positives = 78/217 (35%), Gaps = 25/217 (11%) Query: 123 YQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGG 182 Y +G + + +D ++E + L ++ H + ++ ++ SG Sbjct: 103 YNNKGNILCSSSMDESIKEWHV-----LSGTALKTMSAHSDAVVSIDIPKFDSSILSSGS 157 Query: 183 NDHTIKIWDFYHDYECLRDFQGHNK--------PIKALRFTEDCQSFLSSSFDRSVKIWD 234 D I+I+D + CL+ PI ++F+ + + L S D VK+W+ Sbjct: 158 YDGLIRIFDTESGH-CLKTLTYDKDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWE 216 Query: 235 TETGKVKTRL--HLNSTPADVESR-------PTNPHEFIVGLSNSKILHYDDRVSENQGL 285 G V T A ++ P ++ ++S + + S+N Sbjct: 217 YTRGTVVRTFLWPHQETKAKLKYNCGLELIYPQGKDPLVISGNDSGSMCVWNVYSKNLVQ 276 Query: 286 VQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWEN 322 H S ++++ D K + S + ++ Sbjct: 277 KIDEKHRNSPLISISASYD--KVATLSLNGECNLFRV 311 >1NR0-A nrPDB Length = 611 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 64/357 (17%), Positives = 130/357 (36%), Gaps = 32/357 (8%) Query: 113 SHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLP 172 H + + GY DV ++R + ++ K I + G + + Sbjct: 57 EHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSG---PVKDISWDS 113 Query: 173 KTGHLILSG-GND--HTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQ-SFLSSSFDR 228 ++ + G G + + ++D G + + ++ F +S S D Sbjct: 114 ESKRIAAVGEGRERFGHVFLFDTGTSNGN---LTGQARAMNSVDFKPSRPFRIISGSDDN 170 Query: 229 SVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQT 288 +V I++ K K+ ++ + F + I+ Y+ G+ + Sbjct: 171 TVAIFEGPPFKFKSTFGEHTKFVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTGVFED 230 Query: 289 YD----HHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNV 344 H S+ L + PDG+K S+S DKT++IW K I + L + Sbjct: 231 DSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGI 290 Query: 345 HPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSK 404 ++ + S + I + ++ GH+ A +L+ S DG+ + S D++ Sbjct: 291 IWTKQALVSISANGFI---NFVNPELGSIDQVRYGHNKA--ITALSSSADGKTLFSADAE 345 Query: 405 SRLFTWDWNTS-----------RLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGK 450 + +WD +T ++ IK + V W + KV+ +G +G Sbjct: 346 GHINSWDISTGISNRVFPDVHATMITGIKTTSKGDLFTVSW--DDHLKVVPAGGSGV 400 Score = 100 bits (249), Expect = 1e-21, Method: Composition-based stats. Identities = 48/378 (12%), Positives = 100/378 (26%), Gaps = 88/378 (23%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDF----------------- 202 H L + P G I S D TIKIW+ + + Sbjct: 237 AHSGSVFGLTWSPD-GTKIASASADKTIKIWNVAT-LKVEKTIPVGTRIEDQQLGIIWTK 294 Query: 203 --------------------------QGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTE 236 GHNK I AL + D ++ S+ + + WD Sbjct: 295 QALVSISANGFINFVNPELGSIDQVRYGHNKAITALSSSADGKTLFSADAEGHINSWDIS 354 Query: 237 TGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHY--------------------- 275 TG + T+ + + + Sbjct: 355 TGISNRVFPDVHATMITGIKTTSKGDLFTVSWDDHLKVVPAGGSGVDSSKAVANKLSSQP 414 Query: 276 ---------DDRVSENQGLVQTY-DHHLSSI------LALKYFPDGSKFISSSEDKTVRI 319 D V+ + Y L+ + + D +D V + Sbjct: 415 LGLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHV 474 Query: 320 WENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKG 379 ++ + + + + + + A ++ +S+ ++ + Sbjct: 475 YKLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTF 534 Query: 380 HSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIK--IPGNKPITQVDWHPQ 437 H++ +S +S D + +G + + W+ N I + V W + Sbjct: 535 HTAKVACVS--WSPDNVRLATGSLDNSVIVWNMNKPSDHPIIIKGAHAMSSVNSVIWLNE 592 Query: 438 ETSKVICSGAAGKIYVCD 455 T ++ +G I + Sbjct: 593 TT--IVSAGQDSNIKFWN 608 Score = 76.4 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 43/312 (13%), Positives = 91/312 (29%), Gaps = 49/312 (15%) Query: 144 ISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQ 203 I+F + + GH + TAL G + S + I WD Sbjct: 306 INFVNPELGSIDQVRYGHNKAITALS-SSADGKTLFSADAEGHINSWDISTGISNRVFPD 364 Query: 204 GHNKPIKALRFTEDCQSFLSSSFDRSVKI------------------------------W 233 H I ++ T F + S+D +K+ Sbjct: 365 VHATMITGIKTTSKGDLF-TVSWDDHLKVVPAGGSGVDSSKAVANKLSSQPLGLAVSADG 423 Query: 234 DTETGKVKTRLHLNST----------PADVESRPTNPHEFIVGLSNSKILHYDDRVSENQ 283 D + + S + + + VG +SK+ Y + Sbjct: 424 DIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVYKLSGASVS 483 Query: 284 GLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQI--SDTAQHSMPF 341 + H + I ++ + +G+ +++ + + V + N + + Sbjct: 484 EVKTIV--HPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFHTAKVAC 541 Query: 342 LNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSG 401 ++ P S+DN + +++ I KG + S+ + + I S Sbjct: 542 VSWSPDNVRLATGSLDNSVIVWNMNKPSDH--PIIIKGAHAMSSVNSVIW-LNETTIVSA 598 Query: 402 DSKSRLFTWDWN 413 S + W+ Sbjct: 599 GQDSNIKFWNVP 610 Score = 60.6 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 34/222 (15%), Positives = 65/222 (29%), Gaps = 58/222 (26%) Query: 286 VQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQI------------NVPIKQISD 333 + Y H K P G S VRIW+ + P+K IS Sbjct: 52 TEIYTEHSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISW 111 Query: 334 TAQ---------------------------------HSMPFLNVHPSQNY-FCAQSMDNR 359 ++ +M ++ PS+ + + S DN Sbjct: 112 DSESKRIAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNT 171 Query: 360 IYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLN 419 + F P K F H+ + S+ ++ DG S + ++ Sbjct: 172 VAIFEGPPF---KFKSTFGEHTK--FVHSVRYNPDGSLFASTGGDGTIVLYNGVDGTKTG 226 Query: 420 NIK------IPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 + + + + + W P +K+ + A I + + Sbjct: 227 VFEDDSLKNVAHSGSVFGLTWSPD-GTKIASASADKTIKIWN 267 Score = 56.4 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 20/150 (13%), Positives = 50/150 (33%), Gaps = 12/150 (8%) Query: 90 QDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCY 149 QD VH +++ V S +L V D + I + Sbjct: 468 QDSKVHVYKLSGASVSEVKTI-VHPAEITSVAFSNNGAFL-----VATDQSRKVIPYSVA 521 Query: 150 LPKKVIRN--YPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF--YHDYECLRDFQGH 205 ++ + H + + P + +G D+++ +W+ D+ + Sbjct: 522 NNFELAHTNSWTFHTAKVACVSWSPDN-VRLATGSLDNSVIVWNMNKPSDHPIIIKGAHA 580 Query: 206 NKPIKALRFTEDCQSFLSSSFDRSVKIWDT 235 + ++ + + +S+ D ++K W+ Sbjct: 581 MSSVNSVIWLNETT-IVSAGQDSNIKFWNV 609 >4N14-A nrPDB Length = 314 Score = 142 bits (358), Expect = 2e-34, Method: Composition-based stats. Identities = 41/227 (18%), Positives = 86/227 (37%), Gaps = 15/227 (6%) Query: 103 DSEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHP 162 D +Q + + Y+ + + + + GH Sbjct: 91 DVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEH----HVATLSGHS 146 Query: 163 EGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD---YECLRDFQGHNKPIKALRFTEDCQ 219 + L++ P H + SGGND+ + +W + L+ F H +KA+ + Sbjct: 147 QEVCGLRWAPDGRH-LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQS 205 Query: 220 SFLS---SSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFI-VGLSNSKILHY 275 + L+ + DR ++IW+ +G + + +S + P G + ++++ + Sbjct: 206 NVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIW 265 Query: 276 DDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWEN 322 V H S +L+L PDG+ S++ D+T+R+W Sbjct: 266 K---YPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRC 309 Score = 109 bits (271), Expect = 4e-24, Method: Composition-based stats. Identities = 52/284 (18%), Positives = 98/284 (34%), Gaps = 52/284 (18%) Query: 173 KTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHN--KPIKALRFTEDCQSFLSSSFDRSV 230 +G+++ D+++ +W + L+ Q + I ++ + ++ + V Sbjct: 30 SSGNVLAVA-LDNSVYLWSASSG-DILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEV 87 Query: 231 KIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYD 290 ++WD + K ++ S A V S N + G + I H+D RV+E+ V T Sbjct: 88 QLWDV--QQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHH--VATLS 143 Query: 291 HHLSSILALKYFPDGSKFISSSEDKTVRIWEN---QINVPIKQISDTAQHSMPFLNVHPS 347 H + L++ PDG S D V +W + + Q Q ++ + P Sbjct: 144 GHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPW 203 Query: 348 QNYFCA---QSMDNRIYSFSLKPKYKRHP----------------KKIFKGHSSAGY--- 385 Q+ A + D I +++ K++ GH A Sbjct: 204 QSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLV 263 Query: 386 -------------------GISLAFSGDGRYICSGDSKSRLFTW 410 +SL S DG + S + L W Sbjct: 264 IWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 307 Score = 99.5 bits (246), Expect = 3e-21, Method: Composition-based stats. Identities = 36/256 (14%), Positives = 91/256 (35%), Gaps = 18/256 (7%) Query: 206 NKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPT--NPHEF 263 + + + ++ + L+ + D SV +W +G + L + + S + Sbjct: 21 DYYLNLVDWS--SGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYL 78 Query: 264 IVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQ 323 VG S++++ +D + Q ++ H + + +L + + S S + + + Sbjct: 79 AVGTSSAEVQLWDV---QQQKRLRNMTSHSARVGSLSW--NSYILSSGSRSGHIHHHDVR 133 Query: 324 INVPIKQISDTAQHSMPFLNVH--PSQNYFCAQSMDNRIYSFSLKPKYKRH-PKKIFKGH 380 V ++ + HS + P + + DN + + P P + F H Sbjct: 134 --VAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQH 191 Query: 381 SSAGYGIS-LAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQET 439 A ++ + + G S + W+ + L+ + + + + W P Sbjct: 192 QGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDA--HSQVCSILWSPHYK 249 Query: 440 SKVICSG-AAGKIYVC 454 + G A ++ + Sbjct: 250 ELISGHGFAQNQLVIW 265 Score = 85.6 bits (210), Expect = 4e-17, Method: Composition-based stats. Identities = 26/203 (12%), Positives = 69/203 (33%), Gaps = 13/203 (6%) Query: 258 TNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTV 317 + + ++ + + + L+Q I ++ + +G+ + V Sbjct: 29 WSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGE-YISSVAWIKEGNYLAVGTSSAEV 87 Query: 318 RIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIF 377 ++W+ Q ++ ++ HS ++ + + S I+ ++ Sbjct: 88 QLWDVQQQKRLRNMTS---HSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHH--VATL 142 Query: 378 KGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSR---LLNNIKIPGNKPITQVDW 434 GHS L ++ DGR++ SG + + + W + + V W Sbjct: 143 SGHSQEV--CGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAW 200 Query: 435 HPQETSKVICSGA--AGKIYVCD 455 P +++ + G I + + Sbjct: 201 CPWQSNVLATGGGTSDRHIRIWN 223 >2HES-X nrPDB Length = 330 Score = 141 bits (356), Expect = 4e-34, Method: Composition-based stats. Identities = 54/282 (19%), Positives = 105/282 (37%), Gaps = 24/282 (8%) Query: 155 IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIW------DFYHDYECLRDFQGHNKP 208 + + H + ++ + P T L+ +G D T+ IW D + + L +GH Sbjct: 51 VLDETAHKKAIRSVAWRPHT-SLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENE 109 Query: 209 IKALRFTEDCQSFLSSSFDRSVKIWDT-ETGKVKTRLH-LNSTPADVESRPTNPHE-FIV 265 +K + ++ D + S D+SV IW+T E+G+ + L DV+ +P E + Sbjct: 110 VKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLA 169 Query: 266 GLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKF--ISSSEDKTVRIWENQ 323 S + ++ V + H ++ + + F S S+D TVR+W+ Sbjct: 170 SSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYM 229 Query: 324 INVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRH-----PKKIFK 378 + Q + +P +VH Q Y A + I S + K+F Sbjct: 230 GDDEDDQQEWVCEAILP--DVHKRQVYNVAWGFNGLIASVGADGVLAVYEEVDGEWKVFA 287 Query: 379 GHSSAGYGISLAFSG----DGRY-ICSGDSKSRLFTWDWNTS 415 + + +G+ + +G + W + Sbjct: 288 KRALCHGVYEINVVKWLELNGKTILATGGDDGIVNFWSLEKA 329 Score = 117 bits (294), Expect = 7e-27, Method: Composition-based stats. Identities = 48/324 (14%), Positives = 107/324 (33%), Gaps = 28/324 (8%) Query: 154 VIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF-YHDYECLRDF--QGHNKPIK 210 +I++ + E + F + ++ +G D IK+ Y D+ + H K I+ Sbjct: 6 LIKSLKLYKEKIWSFDF---SQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIR 62 Query: 211 ALRFTEDCQSFLSSSFDRSVKIW-------DTETGKVKTRLHLNSTPADVESRPTNPHEF 263 ++ + + SFD +V IW T + + + + + + Sbjct: 63 SVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYL 122 Query: 264 IVGLSNSKILHYD-DRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW-E 321 + + ++ D E + H + + + P + SSS D TVRIW + Sbjct: 123 ATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKD 182 Query: 322 NQINVPIKQISDTAQHSMPFLNVHPSQNY--FCAQSMDNRIYSF-----SLKPKYKRHPK 374 + + + + ++ + ++ C+ S D+ + + + + + Sbjct: 183 YDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCE 242 Query: 375 KIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTW---DWNTSRLLNNIKIPGNKPITQ 431 I ++A+ +G I S + L + D G I Sbjct: 243 AILPD-VHKRQVYNVAWGFNG-LIASVGADGVLAVYEEVDGEWKVFAKRALCHGVYEINV 300 Query: 432 VDW-HPQETSKVICSGAAGKIYVC 454 V W + + G G + Sbjct: 301 VKWLELNGKTILATGGDDGIVNFW 324 Score = 109 bits (271), Expect = 3e-24, Method: Composition-based stats. Identities = 41/280 (14%), Positives = 88/280 (31%), Gaps = 24/280 (8%) Query: 195 DYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKI----WDTETGKVKTRLHLNSTP 250 ++ + + + I + F++ + S DR +K+ +D T + Sbjct: 3 SINLIKSLKLYKEKIWSFDFSQ--GILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKA 60 Query: 251 ADVESRPTNPHEFIVGLSNSKILHYDDRVSEN----QGLVQTYDHHLSSILALKYFPDGS 306 + + G +S + + S + L+ + H + + + + DG Sbjct: 61 IRSVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGY 120 Query: 307 KFISSSEDKTVRIWENQIN---VPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSF 363 + S DK+V IWE + + + + HPS+ + S D+ + + Sbjct: 121 YLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIW 180 Query: 364 SLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTW--------DWNTS 415 + GH + + +CSG S + W D Sbjct: 181 KDYDDDWE-CVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEW 239 Query: 416 RLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 + + + V W + GA G + V + Sbjct: 240 VCEAILPDVHKRQVYNVAW--GFNGLIASVGADGVLAVYE 277 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 35/231 (15%), Positives = 78/231 (33%), Gaps = 20/231 (8%) Query: 154 VIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD---YECLRDFQGHNKPIK 210 ++ GH + + G+ + + D ++ IW+ YEC+ Q H++ +K Sbjct: 99 LLAIIEGHENEVKGVAWSND-GYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVK 157 Query: 211 ALRFTEDCQSFLSSSFDRSVKIWDTETG--KVKTRLHLNSTPADVESRPTNPHEF-IVGL 267 + + SSS+D +V+IW + L+ + F + Sbjct: 158 HVIWHPSEALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSG 217 Query: 268 SNSKILHYDDRVSENQGLVQTY-------DHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 S+ + + +++ Q + D H + + + +G S D + ++ Sbjct: 218 SDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNG-LIASVGADGVLAVY 276 Query: 321 ENQINVPIKQISDTAQHSMPFLNVHP----SQN-YFCAQSMDNRIYSFSLK 366 E H + +NV + D + +SL+ Sbjct: 277 EEVDGEWKVFAKRALCHGVYEINVVKWLELNGKTILATGGDDGIVNFWSLE 327 Score = 60.6 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 27/207 (13%), Positives = 68/207 (32%), Gaps = 29/207 (14%) Query: 89 DQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLY-PPNDVDVDLREERISFR 147 D+ +++ E + E I V + + Q ++ P++ + + R Sbjct: 128 DKSVWIWETDESGEEYECISVLQ---------EHSQDVKHVIWHPSEALLASSSYDDTVR 178 Query: 148 CY----LPKKVIRNYPGHPEGTTALKFLPKTGHL-ILSGGNDHTIKIW-------DFYHD 195 + + + GH + F G + SG +D T+++W D + Sbjct: 179 IWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQE 238 Query: 196 YECLRDF-QGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGK-----VKTRLHLNST 249 + C H + + + + + S D + +++ G+ + H Sbjct: 239 WVCEAILPDVHKRQVYNVAWGFNG-LIASVGADGVLAVYEEVDGEWKVFAKRALCHGVYE 297 Query: 250 PADVESRPTNPHEFIVGLSNSKILHYD 276 V+ N + + I+++ Sbjct: 298 INVVKWLELNGKTILATGGDDGIVNFW 324 >5K1B-B nrPDB Length = 677 Score = 141 bits (354), Expect = 8e-34, Method: Composition-based stats. Identities = 41/263 (15%), Positives = 99/263 (37%), Gaps = 15/263 (5%) Query: 163 EGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYE--CLRDFQGHNKPIKALRFTEDCQS 220 G AL+ P + + + G D I+IW + + + H + + + ++ Sbjct: 31 NGVNALQLDPA-LNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKT 89 Query: 221 FLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRV- 279 +S+S D +VK+W+ G + L + + + + +I +D Sbjct: 90 LISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTL 149 Query: 280 -----SENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDT 334 S N + + SI +L G+ +S S +K +R+W+ + + ++ Sbjct: 150 TALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKL-KG 208 Query: 335 AQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGD 394 ++ L ++ + S D I +SL ++ ++ H + + + + Sbjct: 209 HTDNVKALLLNRDGTQCLSGSSDGTIRLWSLG---QQRCIATYRVHDEGVWALQVNDAF- 264 Query: 395 GRYICSGDSKSRLFTWDWNTSRL 417 ++ SG +++ D + Sbjct: 265 -THVYSGGRDRKIYCTDLRNPDI 286 Score = 111 bits (278), Expect = 5e-25, Method: Composition-based stats. Identities = 44/265 (16%), Positives = 82/265 (30%), Gaps = 29/265 (10%) Query: 206 NKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKV----KTRLHLNSTPADVESRPTNPH 261 + AL+ ++ D ++IW K + H D+ N Sbjct: 30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLC-CNGK 88 Query: 262 EFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321 I S++ + ++ + + T H + AL Y D S+ D+ + +W+ Sbjct: 89 TLISASSDTTVKVWN---AHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWD 145 Query: 322 NQI--------NVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHP 373 N + S+ L ++ + S + + + + K Sbjct: 146 VNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAK--- 202 Query: 374 KKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVD 433 KGH+ + L + DG SG S + W R + ++ Sbjct: 203 LMKLKGHTDNVKALLL--NRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEG-----V 255 Query: 434 WHPQET---SKVICSGAAGKIYVCD 455 W Q + V G KIY D Sbjct: 256 WALQVNDAFTHVYSGGRDRKIYCTD 280 Score = 86.0 bits (211), Expect = 3e-17, Method: Composition-based stats. Identities = 45/265 (16%), Positives = 94/265 (35%), Gaps = 29/265 (10%) Query: 157 NYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTE 216 + G+ + +L + + G +I+SG + +++WD + ++ +GH +KAL Sbjct: 163 SLSGNKDSIYSLA-MNQLGTIIVSGSTEKVLRVWDPRTCAKLMK-LKGHTDNVKALLLNR 220 Query: 217 DCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYD 276 D LS S D ++++W + ++ G + KI D Sbjct: 221 DGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTD 280 Query: 277 DRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQ 336 R + + L+ +L ++ S D IW + + + Sbjct: 281 LRNPDIRVLICEEKA---PVLKMELDR--------SADPPPAIWVATTKSTVNKWTLKGI 329 Query: 337 HSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGR 396 H N+ + DN + P ++ KG +S L D R Sbjct: 330 H-----------NFRASGDYDND--CTNPITPLCTQPDQVIKGGASIIQCHILN---DKR 373 Query: 397 YICSGDSKSRLFTWDWNTSRLLNNI 421 +I + D+ + + WD + + ++ Sbjct: 374 HILTKDTNNNVAYWDVLKACKVEDL 398 Score = 59.4 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 16/126 (12%), Positives = 49/126 (38%), Gaps = 4/126 (3%) Query: 330 QISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISL 389 ++ ++ + L + P+ N D+ I +S+ + I + + Sbjct: 24 EVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVN--QHKQDPYIASMEHHTDWVNDI 81 Query: 390 AFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAG 449 +G+ + S S + + W+ + ++ ++ +K + + ++ V +G Sbjct: 82 VLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRT--HKDYVKALAYAKDKELVASAGLDR 139 Query: 450 KIYVCD 455 +I++ D Sbjct: 140 QIFLWD 145 Score = 32.1 bits (71), Expect = 0.57, Method: Composition-based stats. Identities = 29/185 (15%), Positives = 45/185 (24%), Gaps = 23/185 (12%) Query: 138 DLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYE 197 + I ++ I Y H EG AL+ H + SGG D I D + Sbjct: 228 GSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTH-VYSGGRDRKIYCTDLRNPDI 286 Query: 198 CLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRP 257 + + P+ + S D IW T + Sbjct: 287 RVLICEE-KAPVLKMELDR--------SADPPPAIWVATTKSTVNK-----------WTL 326 Query: 258 TNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTV 317 H F + Q S I D ++ + V Sbjct: 327 KGIHNFRASGDYDNDCT-NPITPLCTQPDQVIKGGASIIQC-HILNDKRHILTKDTNNNV 384 Query: 318 RIWEN 322 W+ Sbjct: 385 AYWDV 389 >3C9C-A nrPDB Length = 432 Score = 138 bits (346), Expect = 6e-33, Method: Composition-based stats. Identities = 45/236 (19%), Positives = 89/236 (37%), Gaps = 28/236 (11%) Query: 158 YPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLR------DFQGHNKPIKA 211 GH + L + P +LS +DHTI +WD + R F GH ++ Sbjct: 179 LRGHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 238 Query: 212 LRFT-EDCQSFLSSSFDRSVKIWDTETGKVKTRLHL-NSTPADVESRPTNPHE---FIVG 266 + + F S + D+ + IWDT H ++ A+V NP+ G Sbjct: 239 VAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATG 298 Query: 267 LSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKF-ISSSEDKTVRIWEN--- 322 ++ + +D R + + + +++ H I +++ P SS D+ + +W+ Sbjct: 299 SADKTVALWDLRNLKLK--LHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKI 356 Query: 323 --------QINVPIKQISDTAQHSMPFLNVHPSQN---YFCAQSMDNRIYSFSLKP 367 + P + + H+ + + N C+ S DN + + + Sbjct: 357 GEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAE 412 Score = 134 bits (337), Expect = 8e-32, Method: Composition-based stats. Identities = 42/280 (15%), Positives = 97/280 (34%), Gaps = 30/280 (10%) Query: 161 HPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDY---------ECLRDFQGHNKPIKA 211 H +++P+ +I + + ++D+ + +GH K Sbjct: 129 HEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRGHQKEGYG 188 Query: 212 LRFTED-CQSFLSSSFDRSVKIWDTETGKVKTRL--------HLNSTPADVESRPTNPHE 262 L + + LS+S D ++ +WD + R+ + DV + Sbjct: 189 LSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHESL 248 Query: 263 FIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKF-ISSSEDKTVRIWE 321 F + K++ +D R + T D H + + L + P + S DKTV +W+ Sbjct: 249 FGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 308 Query: 322 NQINVPIKQISDTAQHSMPFLNVHP-SQNYFCAQSMDNRIYSFSL---------KPKYKR 371 + ++ + + + P ++ + D R++ + L + Sbjct: 309 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDG 368 Query: 372 HPKKIFKGHSSAGYGISLAFSGDGRY-ICSGDSKSRLFTW 410 P+ +F +++ + + ICS + + W Sbjct: 369 PPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 408 Score = 111 bits (278), Expect = 5e-25, Method: Composition-based stats. Identities = 40/234 (17%), Positives = 77/234 (32%), Gaps = 17/234 (7%) Query: 110 EEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALK 169 YG S L +D + L + + + + + GH + Sbjct: 181 GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 240 Query: 170 FLPKTGHLILSGGNDHTIKIWDFYHD--YECLRDFQGHNKPIKALRFTEDCQSFL-SSSF 226 + L S +D + IWD ++ + H + L F + L + S Sbjct: 241 WHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSA 300 Query: 227 DRSVKIWDTET--GKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYD-------- 276 D++V +WD K+ + V+ P N ++ ++ +D Sbjct: 301 DKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQ 360 Query: 277 ---DRVSENQGLVQTYDHHLSSILALKYFPDGSK-FISSSEDKTVRIWENQINV 326 D L+ + H + I + P+ S SED +++W+ NV Sbjct: 361 STEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENV 414 Score = 102 bits (253), Expect = 4e-22, Method: Composition-based stats. Identities = 35/232 (15%), Positives = 77/232 (33%), Gaps = 16/232 (6%) Query: 239 KVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRV-------SENQGLVQTYDH 291 +++ +++ P N +S +L +D S Sbjct: 122 EIEIKINHEGEVNRARYMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRG 181 Query: 292 HLSSILALKYFPD-GSKFISSSEDKTVRIWENQIN------VPIKQISDTAQHSMPFLNV 344 H L + P+ +S+S+D T+ +W+ + K I + + Sbjct: 182 HQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAW 241 Query: 345 HP-SQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDS 403 H ++ F + + D ++ + + P H++ +S + +G + Sbjct: 242 HLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNP-YSEFILATGSA 300 Query: 404 KSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 + WD +L + I QV W P + + SG +++V D Sbjct: 301 DKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWD 352 Score = 90.6 bits (223), Expect = 1e-18, Method: Composition-based stats. Identities = 42/286 (14%), Positives = 89/286 (31%), Gaps = 42/286 (14%) Query: 205 HNKPIKALRFTEDCQSFLSS---SFDRSVKIWDT--------ETGKVKTRLHLNSTPADV 253 H + R+ +++ S D V ++D +G+ + L L + Sbjct: 129 HEGEVNRARYMPQNACVIATKTPSSD--VLVFDYTKHPSKPEPSGECQPDLRLRGHQKEG 186 Query: 254 ESRPTNPH---EFIVGLSNSKILHYDDRVSENQGLV----QTYDHHLSSILALKYFP-DG 305 NP+ + + I +D + + V + H + + + + Sbjct: 187 YGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVAWHLLHE 246 Query: 306 SKFISSSEDKTVRIWENQINVPIK--QISDTAQHSMPFLNVHPSQNY-FCAQSMDNRIYS 362 S F S ++D+ + IW+ + N K D + L+ +P + S D + Sbjct: 247 SLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 306 Query: 363 FSLKPKYKRHPKKIFKGHSSAGYGISLAFSG-DGRYICSGDSKSRLFTWDWNTSRLLNNI 421 + L+ K+ S + +S + + S + RL WD + + Sbjct: 307 WDLRNL----KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQST 362 Query: 422 -------------KIPGNKPITQVDWHPQETSKVICSGAAGKIYVC 454 I+ W+P E + + V Sbjct: 363 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVW 408 Score = 39.8 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 15/110 (13%), Positives = 39/110 (35%), Gaps = 7/110 (6%) Query: 91 DIFVHALAEDNLDSEQIEVEEVSHFYGKS----EKDYQGRGYLYPPNDVDVDLREERISF 146 D+ L + +S + E+ +V R +++ + + + E Sbjct: 308 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAED 367 Query: 147 RCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDY 196 P +++ + GH + + P +I S D+ +++W + Sbjct: 368 G---PPELLFIHGGHTAKISDFSWNPNEPWIICSVSEDNIMQVWQMAENV 414 >5OQL-L nrPDB Length = 557 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 38/196 (19%), Positives = 82/196 (41%), Gaps = 14/196 (7%) Query: 154 VIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALR 213 +++ + H + K+ P ++S +D T+++WD + + R F GH ++ Sbjct: 136 ILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSN-DPTRLFTGHTDYVRCGA 194 Query: 214 F---TEDCQSFLSSSFDRSVKIWDTET-GKVKTRLHLNSTPADVESRPTNPHEFIVGLSN 269 F + + +S S+D +V++WD G DV P+ ++ S Sbjct: 195 FMPGSANSNLLVSGSYDETVRVWDARAPGGAVMTFKHADPIEDVLPLPSGT--TLLAASG 252 Query: 270 SKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIK 329 + I D ++ L+ +H ++ +L G + +S S D V+++E Sbjct: 253 NAISVLDLVAAKPLRLIT---NHQKTVTSLSLASQGRRVVSGSLDGHVKVFETTSWN--- 306 Query: 330 QISDTAQHSMPFLNVH 345 + A++ P L++ Sbjct: 307 -VVAGAKYPSPILSLS 321 Score = 109 bits (271), Expect = 3e-24, Method: Composition-based stats. Identities = 45/296 (15%), Positives = 94/296 (31%), Gaps = 22/296 (7%) Query: 168 LKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFD 227 + ++ G ++I+ E L+ + D + ++ Sbjct: 64 VAAAKTNDLFAVTAG--PRVEIFSIRK-REPLKTIGRFDSEAHCGEIRPDGRVLVAGEDT 120 Query: 228 RSVKIWDTETGK---VKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQG 284 ++++D G + H++ P V ++ S+ K + D S + Sbjct: 121 GRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSNDPT 180 Query: 285 LVQTYDHHLSSILALKYFP---DGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPF 341 + + H + + P + + +S S D+TVR+W+ + ++ + Sbjct: 181 RL--FTGHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGA-VMTFKHADPIED 237 Query: 342 LNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSG 401 + PS A S N I L P ++ H SL+ + GR + SG Sbjct: 238 VLPLPSGTTLLAASG-NAISVLDL---VAAKPLRLITNHQKTV--TSLSLASQGRRVVSG 291 Query: 402 DSKSRLFTWDWNTSRLLNNIKIP----GNKPITQVDWHPQETSKVICSGAAGKIYV 453 + ++ + ++ K P IT H V I Sbjct: 292 SLDGHVKVFETTSWNVVAGAKYPSPILSLSVITAGASHDDRHLAVGMQSGVLSIRT 347 Score = 57.5 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 26/141 (18%), Positives = 46/141 (32%), Gaps = 12/141 (8%) Query: 322 NQINVPIKQISDTAQHSMPFLNVH-----PSQNYFCAQSMDNRIYSFSLKPKYKRHPKKI 376 + N PI IS A L N A + R+ FS++ + Sbjct: 38 STANWPISHISFPASLGTTALVSSSLVAAAKTNDLFAVTAGPRVEIFSIRKREPLKTIGR 97 Query: 377 FKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKI--PGNKPITQVDW 434 F + G DGR + +G+ R+ +D +K +P+ W Sbjct: 98 FDSEAHCGEIR-----PDGRVLVAGEDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKW 152 Query: 435 HPQETSKVICSGAAGKIYVCD 455 P E + ++ + + D Sbjct: 153 SPTELTTLMSCSDDKTVRLWD 173 >4XFV-A nrPDB Length = 792 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 61/371 (16%), Positives = 113/371 (30%), Gaps = 73/371 (19%) Query: 145 SFRCYLP-----KKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF--YHDYE 197 + + P K V GH T ++F+P + ++S DH +KIW F Y + Sbjct: 41 TIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDS-DFMVSASEDHHVKIWKFTDYSHLQ 99 Query: 198 CLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNST-------P 250 C++ Q ++K I AL S D ++ IW + L T P Sbjct: 100 CIQTIQHYSKTIVALSALPSLISV--GCADGTISIWRQNIQNDEFGLAHEFTIKKGFFYP 157 Query: 251 ADVESRPTNPHEFIVGLSNSKILHY------DDRVSENQGLVQTYDHHLSSILALKY--- 301 + ++++ + + + + D E +V + H + +L + Sbjct: 158 LCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQ 217 Query: 302 -FPDGSKFISSSEDKTVRIWENQINVPI-------------------------------- 328 P S S+D+ +R+W +IN I Sbjct: 218 ETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINF 277 Query: 329 KQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGIS 388 + + + L H S+ A + D + + + G S+ + Sbjct: 278 EALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGAST 337 Query: 389 LAFSGDGRYIC------------SGDSKSRLFTWDWN-TSRLLNNIKIPG-NKPITQVDW 434 S G + C + W + I G K +T + W Sbjct: 338 ATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDVTDIAW 397 Query: 435 HPQETSKVICS 445 P + S Sbjct: 398 SPSGEYLLATS 408 Score = 86.4 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 33/207 (15%), Positives = 77/207 (37%), Gaps = 13/207 (6%) Query: 261 HEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 + + + I +D N+G+ T H + + +++ PD +S+SED V+IW Sbjct: 31 KKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIW 90 Query: 321 ENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGH 380 + ++ I +S + + + D I + + Sbjct: 91 KFTDYSHLQCIQTIQHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFTI 150 Query: 381 SSAGY---GISLAFSGDGRYICS-GDSKSRLFTW-----DWNTSRLLNNIKIPGNKP-IT 430 + +SL+ + +Y+ + G + +F D + ++ G++ + Sbjct: 151 KKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEGHEDWVK 210 Query: 431 QVDWHPQET--SKVICSGA-AGKIYVC 454 + + QET ++CSG+ I + Sbjct: 211 SLAFRHQETPGDYLLCSGSQDRYIRLW 237 Score = 82.6 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 40/254 (15%), Positives = 79/254 (31%), Gaps = 50/254 (19%) Query: 185 HTIKIWDF--YHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIW---DTETGK 239 TI +WD ++ +GH + +RF D +S+S D VKIW D + Sbjct: 40 KTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYSHLQ 99 Query: 240 VKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILAL 299 + S + P VG ++ I + + ++ + H +I Sbjct: 100 CIQTIQHYSKTIV--ALSALPSLISVGCADGTISIWRQNIQNDEFGLA----HEFTIKKG 153 Query: 300 KYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNR 359 ++P +S S+ V + + Sbjct: 154 FFYP---LCLSLSK------------------------------VEEKKYLLAIGGTNVN 180 Query: 360 IYS--FSLKPKYKRHPKKIFKGHSSAGYGISLAF----SGDGRYICSGDSKSRLFTWDWN 413 ++ F L + + + + SLAF + +CSG + W Sbjct: 181 VFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIR 240 Query: 414 TSRLLNNIKIPGNK 427 + L+++ + K Sbjct: 241 INDLIDDSEEDSKK 254 Score = 81.4 bits (199), Expect = 8e-16, Method: Composition-based stats. Identities = 41/289 (14%), Positives = 89/289 (30%), Gaps = 63/289 (21%) Query: 153 KVIRNYPGHPEGTTALKF---LPKTGHLILSGGNDHTIKIW------------------- 190 +V+ GH + +L F +L+ SG D I++W Sbjct: 197 RVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLT 256 Query: 191 -------------DFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWD--- 234 + GH+ I +L++ E L+++ D S+ +W+ Sbjct: 257 LLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDE 316 Query: 235 --------TETGKVKTRLHLNSTPA------DVESRPTNPHEFIVGLSNSKILHYDDRVS 280 G++ ++ +T + + F+ + + + Sbjct: 317 TSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDN 376 Query: 281 ENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRI---WENQINVPIKQISDTAQH 337 + + + P G +++S D+T R+ W + ++I+ + Sbjct: 377 IICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEF 436 Query: 338 SMP-------FLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKG 379 S P + F + + + SF L PK + F G Sbjct: 437 SRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDL-PKGVAGMLQKFVG 484 Score = 76.0 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 60/367 (16%), Positives = 114/367 (31%), Gaps = 72/367 (19%) Query: 150 LPKKVIRNYPGHPEGTTALKFLPKTG-HLILSGGNDHTIKIWDFYHDYECLRDF--QGHN 206 + K G G + + L+ G + ++W + C + G Sbjct: 330 MSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGAT 389 Query: 207 KPIKALRFTEDCQSFLSSSFDRSVKI---WDTE-TGKVKTRLHLNS------TPADVESR 256 K + + ++ + L++S D++ ++ W + +G+ + + D+ Sbjct: 390 KDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICV 449 Query: 257 PTNPHEFIVGLSNSKILHYDDRVSENQGLVQTY------------DHHLSSILALKY--- 301 T V + KIL D G++Q + D +L L Sbjct: 450 ETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAG 509 Query: 302 -----------------FPDGSKFIS-----SSEDKTVR--IWENQINVPIKQISDTAQH 337 PD + +S ED+ R +W P + Sbjct: 510 EDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLW------PEVEKLYGHGF 563 Query: 338 SMPFLNVHPSQNYFCAQSMDNR-----IYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFS 392 + L++ P Q + N I FS + + P F + L FS Sbjct: 564 EITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPF----HSLTITRLKFS 619 Query: 393 GDGRYICSGDSKSRLFTWDW----NTSRLLNNIKIPGNKPITQVDWHPQE-TSKVICSGA 447 DG+++ S + W+ NT L + P + I DW P E + + + Sbjct: 620 KDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASR 679 Query: 448 AGKIYVC 454 + V Sbjct: 680 DKTVKVW 686 Score = 71.4 bits (173), Expect = 7e-13, Method: Composition-based stats. Identities = 38/244 (15%), Positives = 78/244 (31%), Gaps = 28/244 (11%) Query: 149 YLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDH-----TIKIWDFYHDYECLRDFQ 203 +L + GH T L P LI S + I+I+ + E Sbjct: 549 HLLWPEVEKLYGHGFEITCLDISPDQ-KLIASACRSNNVQNAVIRIFSTENWLEIKPALP 607 Query: 204 GHNKPIKALRFTEDCQSFLSSSFDRSVKIW--DTETGKVKTRLHLNSTPADVESRPT--- 258 H+ I L+F++D + LS DR +W + E + R + Sbjct: 608 FHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELRFKNEKPHTRIIWDADWAP 667 Query: 259 --NPHEFIVGLSNSKILHYD-DRVSENQGLVQTYDHHLSSILALKYFPD---GSKFISSS 312 + F+ + + + + + +++ H ++ A+ IS Sbjct: 668 LEFGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVG 727 Query: 313 -EDKTVRIWENQINVPIKQISDTAQHSMPFLNV------HPSQN---YFCAQSMDNRIYS 362 E+ + ++ + + I+ + P + H +N + S D Sbjct: 728 LENGEIYLYSYTLGK-FELITQLNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRI 786 Query: 363 FSLK 366 +SL Sbjct: 787 YSLA 790 >6EOJ-D nrPDB Length = 470 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 40/184 (21%), Positives = 75/184 (40%), Gaps = 4/184 (2%) Query: 139 LREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYEC 198 + + + K R GH + + P+ G LI S D+ +K+WD C Sbjct: 196 SDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMG-LIASASKDNLVKLWDPRSG-NC 253 Query: 199 LRDFQGHNKPIKALRFTEDCQSFLSS-SFDRSVKIWDTETGKVKTRLHLNST-PADVESR 256 + + RF + L + S D+S +++D + + T +E Sbjct: 254 ISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWH 313 Query: 257 PTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKT 316 P N F + + + H+D + N+ ++ H I +L Y P G F ++++D+T Sbjct: 314 PINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKCITSLSYNPVGHIFATAAKDRT 373 Query: 317 VRIW 320 +R W Sbjct: 374 IRFW 377 Score = 130 bits (327), Expect = 1e-30, Method: Composition-based stats. Identities = 46/256 (17%), Positives = 95/256 (37%), Gaps = 12/256 (4%) Query: 158 YPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQG-HNKPIKALRFTE 216 H T +K+ ++SG D IKIW ++ +++ H + I+ + F+ Sbjct: 131 MQAHDSAVTTMKYS-HDSDWMISGDADGMIKIW--QPNFSMVKEIDAAHTESIRDMAFSS 187 Query: 217 DCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYD 276 + F++ S D +KIW+ GK + L + ++ + +D Sbjct: 188 NDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWDVKSCDWHPEMGLIASASKDNLVKLWD 247 Query: 277 DRVSENQGLVQTYDHHLSSILALKYFPD-GSKFISSSEDKTVRIWENQINVPIKQISDTA 335 R + + H +L ++ P G+ ++ S+DK+ R+++ + ++ Sbjct: 248 PRSGNCISSILKFK-HT--VLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDE 304 Query: 336 QHSMPFLNVHP-SQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGD 394 M L HP +++ F D + F L I H SL+++ Sbjct: 305 TDYMT-LEWHPINESMFTLACYDGSLKHFDLLQNLNEPILTIPYAHDKC--ITSLSYNPV 361 Query: 395 GRYICSGDSKSRLFTW 410 G + + W Sbjct: 362 GHIFATAAKDRTIRFW 377 Score = 112 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 43/292 (14%), Positives = 98/292 (33%), Gaps = 21/292 (7%) Query: 166 TALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSS 225 + +P + G D I + + + I A+++T + + + ++ Sbjct: 61 YTIDIMPPNAYR----GRDRVINLPSKFTHLSSNKV----KHVIPAIQWTPEGRRLVVAT 112 Query: 226 FDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGL 285 + +W+ + +T + + + + I G ++ I + N + Sbjct: 113 YSGEFSLWNASSFTFETLMQAHDSAVTTMKYSHDSDWMISGDADGMIKIW----QPNFSM 168 Query: 286 VQTYD-HHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNV 344 V+ D H SI + + + SKF++ S+D ++IW + +S + + Sbjct: 169 VKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHWD-VKSCDW 227 Query: 345 HPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGD-GRYICSGDS 403 HP + S DN + + + FK + F G + + Sbjct: 228 HPEMGLIASASKDNLVKLWDPRSGNCISSILKFK-----HTVLKTRFQPTKGNLLMAISK 282 Query: 404 KSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 +D S + + + ++WHP S + G + D Sbjct: 283 DKSCRVFDIRYS-MKELMCVRDETDYMTLEWHPINESMFTLACYDGSLKHFD 333 >3ODT-A nrPDB Length = 313 Score = 135 bits (340), Expect = 3e-32, Method: Composition-based stats. Identities = 53/225 (23%), Positives = 101/225 (44%), Gaps = 19/225 (8%) Query: 155 IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKA--- 211 + GH +L F +++SG D T K+W + + + Q HN + Sbjct: 97 LYTLIGHQGNVCSLSF---QDGVVISGSWDKTAKVWK---EGSLVYNLQAHNASVWDAKV 150 Query: 212 LRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSK 271 + F+E FL++S D+++K+W +KT +++ + + H FI ++ Sbjct: 151 VSFSE--NKFLTASADKTIKLWQ-NDKVIKTFSGIHNDVVRHLAVVDDGH-FISCSNDGL 206 Query: 272 ILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQI 331 I D + +++TY+ H S + +K P+G +S ED+TVRIW ++ N +KQ+ Sbjct: 207 IKLVDMHTGD---VLRTYEGHESFVYCIKLLPNGD-IVSCGEDRTVRIW-SKENGSLKQV 261 Query: 332 SDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKI 376 S+ ++ + + S DN + FS + +I Sbjct: 262 ITLPAISIWSVDCMSNGDIIV-GSSDNLVRIFSQEKSRWASEDEI 305 Score = 114 bits (286), Expect = 7e-26, Method: Composition-based stats. Identities = 54/312 (17%), Positives = 107/312 (34%), Gaps = 30/312 (9%) Query: 148 CYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNK 207 + ++ GH + + + + + S D T+++W + + G Sbjct: 4 PFTGYQLSATLKGHDQDVRDVVAVDDS--KVASVSRDGTVRLWSKDDQWLGTVVYTG-QG 60 Query: 208 PIKALRFTEDCQSFLSSSFD---RSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFI 264 + ++ + + + L D V ++ T L + +V S I Sbjct: 61 FLNSVCYDSEKELLLFGGKDTMINGVPLFATSGEDPLYTLIGHQG--NVCSLSFQDGVVI 118 Query: 265 VGLSNSKILHYDDRVSENQGLVQTYDHHLSSILA---LKYFPDGSKFISSSEDKTVRIWE 321 G + + + LV H +S+ + + + KF+++S DKT+++W Sbjct: 119 SGSWDKTAKVW-----KEGSLVYNLQAHNASVWDAKVVSFSEN--KFLTASADKTIKLW- 170 Query: 322 NQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHS 381 Q + IK S + L V ++ + S D I + + ++GH Sbjct: 171 -QNDKVIKTFSGIHNDVVRHLAVVDDGHFI-SCSNDGLIKLVDMHTGDV---LRTYEGHE 225 Query: 382 SAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSK 441 S Y I L +GD I S + W L I +P I VD Sbjct: 226 SFVYCIKLLPNGD---IVSCGEDRTVRIWSKENGSLKQVITLPA-ISIWSVDCMSNGD-- 279 Query: 442 VICSGAAGKIYV 453 +I + + + Sbjct: 280 IIVGSSDNLVRI 291 Score = 102 bits (254), Expect = 3e-22, Method: Composition-based stats. Identities = 41/203 (20%), Positives = 75/203 (36%), Gaps = 10/203 (4%) Query: 122 DYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSG 181 +QG D V + + + ++ N H K + + + L+ Sbjct: 102 GHQGNVCSLSFQDGVVISGSWDKTAKVWKEGSLVYNLQAHNASVWDAKVVSFSENKFLTA 161 Query: 182 GNDHTIKIWDFYHDYECLRDFQG-HNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKV 240 D TIK+W + + ++ F G HN ++ L +D F+S S D +K+ D TG V Sbjct: 162 SADKTIKLW---QNDKVIKTFSGIHNDVVRHLAVVDDGH-FISCSNDGLIKLVDMHTGDV 217 Query: 241 KTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALK 300 + + N IV + + + + + V T SI ++ Sbjct: 218 LRTYEGHESFVYCIKLLPNGD--IVSCGEDRTVRIWSKENGSLKQVITLPA--ISIWSVD 273 Query: 301 YFPDGSKFISSSEDKTVRIWENQ 323 +G + S D VRI+ + Sbjct: 274 CMSNGDIIV-GSSDNLVRIFSQE 295 >5Y1U-A nrPDB Length = 456 Score = 135 bits (339), Expect = 4e-32, Method: Composition-based stats. Identities = 44/236 (18%), Positives = 89/236 (37%), Gaps = 28/236 (11%) Query: 158 YPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFY------HDYECLRDFQGHNKPIKA 211 GH + L + P +LS +DHTI +WD + F GH ++ Sbjct: 204 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 263 Query: 212 LRFT-EDCQSFLSSSFDRSVKIWDTETGKVKTRLHL-NSTPADVESRPTNPHE---FIVG 266 + + F S + D+ + IWDT + H ++ A+V NP+ G Sbjct: 264 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 323 Query: 267 LSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKF-ISSSEDKTVRIWEN--- 322 ++ + +D R + + + +++ H I +++ P SS D+ + +W+ Sbjct: 324 SADKTVALWDLRNLKLK--LHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKI 381 Query: 323 --------QINVPIKQISDTAQHSMPFLNVHPSQNY---FCAQSMDNRIYSFSLKP 367 + P + + H+ + + N C+ S DN + + + Sbjct: 382 GEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 437 Score = 132 bits (331), Expect = 3e-31, Method: Composition-based stats. Identities = 46/280 (16%), Positives = 100/280 (35%), Gaps = 30/280 (10%) Query: 161 HPEGTTALKFLPKTGHLILSG--GNDHTIKIW-------DFYHDYECLRDFQGHNKPIKA 211 H +++P+ +I + +D + + D + +GH K Sbjct: 154 HEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYG 213 Query: 212 LRFTED-CQSFLSSSFDRSVKIWDT----ETGKV---KTRLHLNSTPA-DVESRPTNPHE 262 L + + LS+S D ++ +WD + GKV KT ++ DV + Sbjct: 214 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 273 Query: 263 FIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKF-ISSSEDKTVRIWE 321 F + K++ +D R + + D H + + L + P + S DKTV +W+ Sbjct: 274 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 333 Query: 322 NQINVPIKQISDTAQHSMPFLNVHP-SQNYFCAQSMDNRIYSFSL---------KPKYKR 371 + ++ + + + P ++ + D R+ + L + Sbjct: 334 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDG 393 Query: 372 HPKKIFKGHSSAGYGISLAFSGDGRY-ICSGDSKSRLFTW 410 P+ +F +++ + + ICS + + W Sbjct: 394 PPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 433 Score = 107 bits (266), Expect = 1e-23, Method: Composition-based stats. Identities = 33/186 (17%), Positives = 64/186 (34%), Gaps = 17/186 (9%) Query: 158 YPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD--YECLRDFQGHNKPIKALRFT 215 + GH + + L S +D + IWD + + H + L F Sbjct: 254 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN 313 Query: 216 EDCQSFL-SSSFDRSVKIWDTETGKV--KTRLHLNSTPADVESRPTNPHEFIVGLSNSKI 272 + L + S D++V +WD K+ + V+ P N ++ ++ Sbjct: 314 PYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 373 Query: 273 LHYD-----------DRVSENQGLVQTYDHHLSSILALKYFPDGSK-FISSSEDKTVRIW 320 +D D L+ + H + I + P+ S SED +++W Sbjct: 374 NVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 433 Query: 321 ENQINV 326 + N+ Sbjct: 434 QMAENI 439 Score = 102 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 38/232 (16%), Positives = 79/232 (34%), Gaps = 16/232 (6%) Query: 239 KVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYD-------DRVSENQGLVQTYDH 291 +++ +++ P NP +S +L +D S Sbjct: 147 EIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRG 206 Query: 292 HLSSILALKYFPDGS-KFISSSEDKTVRIWENQIN------VPIKQISDTAQHSMPFLNV 344 H L + P+ S +S+S+D T+ +W+ V K I + ++ Sbjct: 207 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 266 Query: 345 HP-SQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDS 403 H ++ F + + D ++ + + P H++ +S + +G + Sbjct: 267 HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP-YSEFILATGSA 325 Query: 404 KSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 + WD +L + I QV W P + + SG ++ V D Sbjct: 326 DKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 377 Score = 92.6 bits (228), Expect = 3e-19, Method: Composition-based stats. Identities = 44/286 (15%), Positives = 89/286 (31%), Gaps = 42/286 (14%) Query: 205 HNKPIKALRFTEDCQSFLSS---SFDRSVKIWDT--------ETGKVKTRLHLNSTPADV 253 H + R+ +++ S D V ++D +G+ L L + Sbjct: 154 HEGEVNRARYMPQNPCIIATKTPSSD--VLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG 211 Query: 254 ESRPTNPH---EFIVGLSNSKILHYDDRVSENQGLV----QTYDHHLSSILALKYFP-DG 305 NP+ + + I +D +G V + H + + + + Sbjct: 212 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE 271 Query: 306 SKFISSSEDKTVRIWENQINVPIK--QISDTAQHSMPFLNVHPSQNY-FCAQSMDNRIYS 362 S F S ++D+ + IW+ + N K D + L+ +P + S D + Sbjct: 272 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 331 Query: 363 FSLKPKYKRHPKKIFKGHSSAGYGISLAFSG-DGRYICSGDSKSRLFTWDWNTSRLLNN- 420 + L+ K+ S + +S + + S + RL WD + + Sbjct: 332 WDLRNL----KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSP 387 Query: 421 ------------IKIPGNKPITQVDWHPQETSKVICSGAAGKIYVC 454 I I+ W+P E + + V Sbjct: 388 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 433 Score = 57.9 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 17/120 (14%), Positives = 40/120 (33%), Gaps = 17/120 (14%) Query: 131 PPNDVDVDLREERISFRCYLPKKV---IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTI 187 P ++ + + + + + + ++ H + +++ P ++ S G D + Sbjct: 314 PYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 373 Query: 188 KIWDFYH-------------DYECLRDFQGHNKPIKALRFTEDCQS-FLSSSFDRSVKIW 233 +WD E L GH I + + S S D +++W Sbjct: 374 NVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 433 Score = 37.1 bits (84), Expect = 0.015, Method: Composition-based stats. Identities = 16/106 (15%), Positives = 36/106 (33%), Gaps = 1/106 (0%) Query: 91 DIFVHALAEDNLDSEQIEVEEVSHFYGKSEK-DYQGRGYLYPPNDVDVDLREERISFRCY 149 D+ L + +S + E+ +V G D+ E+ Sbjct: 333 DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAED 392 Query: 150 LPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD 195 P +++ + GH + + P +I S D+ +++W + Sbjct: 393 GPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 438 >3CFV-B nrPDB Length = 414 Score = 134 bits (336), Expect = 1e-31, Method: Composition-based stats. Identities = 44/236 (18%), Positives = 89/236 (37%), Gaps = 28/236 (11%) Query: 158 YPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD------YECLRDFQGHNKPIKA 211 GH + L + +LS +DHT+ +WD + F GH+ ++ Sbjct: 175 LRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVED 234 Query: 212 LRFT-EDCQSFLSSSFDRSVKIWDTETGKVKTRLHL-NSTPADVESRPTNPHE---FIVG 266 + + F S + D+ + IWDT + HL ++ A+V NP+ G Sbjct: 235 VAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATG 294 Query: 267 LSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKF-ISSSEDKTVRIWEN--- 322 ++ + +D R + + + T++ H I + + P SS D+ + +W+ Sbjct: 295 SADKTVALWDLRNLKLK--LHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKI 352 Query: 323 --------QINVPIKQISDTAQHSMPFLNVHPSQNY---FCAQSMDNRIYSFSLKP 367 + P + + H+ + + N C+ S DN + + + Sbjct: 353 GEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAE 408 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 44/280 (15%), Positives = 99/280 (35%), Gaps = 30/280 (10%) Query: 161 HPEGTTALKFLPKTGHLILSG--GNDHTIKIW-------DFYHDYECLRDFQGHNKPIKA 211 H +++P+ H+I + +D + + D + +GH K Sbjct: 125 HEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYG 184 Query: 212 LRFTED-CQSFLSSSFDRSVKIWDTETGKVKTRL--------HLNSTPADVESRPTNPHE 262 L + + LS+S D +V +WD G + ++ ++ DV + Sbjct: 185 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 244 Query: 263 FIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKF-ISSSEDKTVRIWE 321 F + K++ +D R + D H + + L + P + S DKTV +W+ Sbjct: 245 FGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 304 Query: 322 NQINVPIKQISDTAQHSMPFLNVHP-SQNYFCAQSMDNRIYSFSL---------KPKYKR 371 + ++ + + ++ P ++ + D R+ + L + Sbjct: 305 LRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDG 364 Query: 372 HPKKIFKGHSSAGYGISLAFSGDGRY-ICSGDSKSRLFTW 410 P+ +F +++ + + ICS + + W Sbjct: 365 PPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIW 404 Score = 106 bits (263), Expect = 3e-23, Method: Composition-based stats. Identities = 35/186 (18%), Positives = 63/186 (33%), Gaps = 17/186 (9%) Query: 158 YPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDY--ECLRDFQGHNKPIKALRFT 215 + GH + + L S +D + IWD + + H + L F Sbjct: 225 FTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFN 284 Query: 216 EDCQSFL-SSSFDRSVKIWDTETGKV--KTRLHLNSTPADVESRPTNPHEFIVGLSNSKI 272 + L + S D++V +WD K+ T V P N ++ ++ Sbjct: 285 PYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRL 344 Query: 273 LHYD-----------DRVSENQGLVQTYDHHLSSILALKYFPDGSK-FISSSEDKTVRIW 320 +D D L+ + H + I + P+ S SED ++IW Sbjct: 345 NVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIW 404 Query: 321 ENQINV 326 + N+ Sbjct: 405 QMAENI 410 Score = 104 bits (258), Expect = 1e-22, Method: Composition-based stats. Identities = 39/232 (16%), Positives = 78/232 (33%), Gaps = 16/232 (6%) Query: 239 KVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYD-------DRVSENQGLVQTYDH 291 + + +++ P NPH +S +L +D S Sbjct: 118 ECEIKINHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRG 177 Query: 292 HLSSILALKYFPDGS-KFISSSEDKTVRIWENQIN------VPIKQISDTAQHSMPFLNV 344 H L + + S +S+S+D TV +W+ V K I + + Sbjct: 178 HQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAW 237 Query: 345 HP-SQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDS 403 H ++ F + + D ++ + + P + H++ +S + +G + Sbjct: 238 HLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNP-YSEFILATGSA 296 Query: 404 KSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 + WD +L + I QV W P + + SG ++ V D Sbjct: 297 DKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWD 348 Score = 93.7 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 40/286 (13%), Positives = 91/286 (31%), Gaps = 42/286 (14%) Query: 205 HNKPIKALRFTEDCQSFLSS---SFDRSVKIWDT--------ETGKVKTRLHLNSTPADV 253 H + R+ +++ S D V ++D +G+ L L + Sbjct: 125 HEGEVNRARYMPQNPHIIATKTPSSD--VLVFDYTKHPAKPDPSGECNPDLRLRGHQKEG 182 Query: 254 ESRPTNPH---EFIVGLSNSKILHYDDRVSENQGLV----QTYDHHLSSILALKYFP-DG 305 N + + + + +D +G + + H + + + + Sbjct: 183 YGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHE 242 Query: 306 SKFISSSEDKTVRIWENQINVPIK--QISDTAQHSMPFLNVHPSQNY-FCAQSMDNRIYS 362 S F S ++D+ + IW+ + N K + D + L+ +P + S D + Sbjct: 243 SLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 302 Query: 363 FSLKPKYKRHPKKIFKGHSSAGYGISLAFSG-DGRYICSGDSKSRLFTWDWNTSRLLNN- 420 + L+ + F+ H + + +S + + S + RL WD + + Sbjct: 303 WDLRNL--KLKLHTFESHKDEIF--QVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSA 358 Query: 421 ------------IKIPGNKPITQVDWHPQETSKVICSGAAGKIYVC 454 I I+ W+P E + + + Sbjct: 359 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIW 404 Score = 57.9 bits (138), Expect = 9e-09, Method: Composition-based stats. Identities = 18/120 (15%), Positives = 38/120 (31%), Gaps = 17/120 (14%) Query: 131 PPNDVDVDLREERISFRCYLPKKV---IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTI 187 P ++ + + + + + + + H + + + P ++ S G D + Sbjct: 285 PYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRL 344 Query: 188 KIWDFYH-------------DYECLRDFQGHNKPIKALRFTEDCQS-FLSSSFDRSVKIW 233 +WD E L GH I + + S S D ++IW Sbjct: 345 NVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIW 404 Score = 37.1 bits (84), Expect = 0.015, Method: Composition-based stats. Identities = 9/45 (20%), Positives = 20/45 (44%) Query: 151 PKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD 195 P +++ + GH + + P +I S D+ ++IW + Sbjct: 365 PPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAEN 409 >5MWJ-A nrPDB Length = 337 Score = 134 bits (336), Expect = 1e-31, Method: Composition-based stats. Identities = 42/200 (21%), Positives = 76/200 (38%), Gaps = 9/200 (4%) Query: 166 TALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSS 225 AL P + + S +D I +WD H+ +R FQGH + + D + Sbjct: 145 YALAISPDS-KVCFSCCSDGNIAVWDL-HNQTLVRQFQGHTDGASCIDISNDGTKLWTGG 202 Query: 226 FDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGL 285 D +V+ WD G+ + S + PT VG+ +S + + Sbjct: 203 LDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGE-WLAVGMESSNVEVLHVNKPDKYQ- 260 Query: 286 VQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVH 345 H S +L+LK+ G F+S+ +D + W I Q +++ S+ ++ Sbjct: 261 ---LHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESS--SVLSCDIS 315 Query: 346 PSQNYFCAQSMDNRIYSFSL 365 Y S D + + + Sbjct: 316 VDDKYIVTGSGDKKATVYEV 335 Score = 101 bits (252), Expect = 5e-22, Method: Composition-based stats. Identities = 36/285 (12%), Positives = 77/285 (27%), Gaps = 45/285 (15%) Query: 205 HNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLH-----LNSTPADVESRPTN 259 H + + A+ + + + VK+WD K+ + + Sbjct: 50 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPD 108 Query: 260 PHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRI 319 IVG S + +D + + + AL PD S D + + Sbjct: 109 GCTLIVGGEASTLSIWDL-AAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAV 167 Query: 320 WENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKR-------- 371 W+ ++Q +++ +DN + S+ L+ + Sbjct: 168 WDLHNQTLVRQ-FQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQ 226 Query: 372 ---------------------------HPKKIFKGHSSAGYGISLAFSGDGRYICSGDSK 404 + ++ H +SL F+ G++ S Sbjct: 227 IFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKD 286 Query: 405 SRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAG 449 + L W + + + + D + V SG Sbjct: 287 NLLNAWRTPYG--ASIFQSKESSSVLSCDISVDDKYIVTGSGDKK 329 Score = 76.0 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 25/169 (14%), Positives = 55/169 (32%), Gaps = 10/169 (5%) Query: 291 HHLSSILALKYFPDGSKFISSSEDKTVRIWENQ---INVPIKQISDTAQHS-MPFLNVHP 346 +H + A+ + + V++W+ P+ Q+ + + + + P Sbjct: 49 NHGEVVCAVTISNPTRHVYTGGK-GCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLP 107 Query: 347 SQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSR 406 + + + L P+ + SSA +LA S D + S S Sbjct: 108 DGCTLIVGGEASTLSIWDLA---APTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGN 164 Query: 407 LFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 + WD + L+ + G+ + +K+ G + D Sbjct: 165 IAVWDLHNQTLVRQFQ--GHTDGASCIDISNDGTKLWTGGLDNTVRSWD 211 >4YCZ-A nrPDB Length = 876 Score = 132 bits (331), Expect = 4e-31, Method: Composition-based stats. Identities = 40/283 (14%), Positives = 94/283 (33%), Gaps = 36/283 (12%) Query: 159 PGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLR-DFQGHNKPIKALRFTED 217 GH + L G + + +D TIKI++ + + L +GH+ + + + Sbjct: 15 SGHDDMIHD-AVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHP 73 Query: 218 --CQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHE----FIVGLSNSK 271 S+ +D V IW G + A V +PHE S+ Sbjct: 74 KYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGN 133 Query: 272 ILHYDDRVSENQGLVQTYDHHLSSILALKYFP-----------------DGSKFISSSED 314 + + R + + + + H + ++ + P +F++ D Sbjct: 134 VSVLEFRDNSWEHSI--FHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSD 191 Query: 315 KTVRIWENQINVPIKQI----SDTAQHSMPFLNVHPS---QNYFCAQSMDNRIYSFSLKP 367 ++IW ++ + + P+ ++Y + S D + ++ P Sbjct: 192 NALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDP 251 Query: 368 KYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTW 410 +A + +++S G + + +++ W Sbjct: 252 ANPLQWNCKVLNFDAAVW--RVSWSLSGNVLAASGGDNKVTLW 292 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 44/257 (17%), Positives = 95/257 (36%), Gaps = 29/257 (11%) Query: 151 PKKVIRNYPGHPEGTTALKF-LPKTGHLILSGGNDHTIKIW-DFYHDYECLRDFQGHNKP 208 +++ GH + + PK G+++ S G D + IW + ++ + DF H Sbjct: 51 TQRLTETLKGHDGAVWCVSWAHPKYGNILASAGYDGKVLIWRELNGAWQRIFDFALHKAS 110 Query: 209 IKALRFTED--CQSFLSSSFDRSVKIWDTETGK-VKTRLHLN------------STPADV 253 + + ++ +S D +V + + + H + ++P + Sbjct: 111 VNVVSWSPHEAGCLLACASSDGNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSI 170 Query: 254 ESRPTNPHE-----FIVGLSNSKILHY--DDRVSENQGLVQTYDHHLSSILALKYFPDG- 305 S P F+ G S++ + + D + + + H + + + P Sbjct: 171 VSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVL 230 Query: 306 --SKFISSSEDKTVRIWENQINVPIKQISDTAQ--HSMPFLNVHPSQNYFCAQSMDNRIY 361 S S+SED+TVRIW + P++ ++ ++ S N A DN++ Sbjct: 231 QKSYIASASEDRTVRIWTSDPANPLQWNCKVLNFDAAVWRVSWSLSGNVLAASGGDNKVT 290 Query: 362 SFSLKPKYKRHPKKIFK 378 + K + K + Sbjct: 291 LWKENLKGEWECVKTIE 307 Score = 112 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 40/278 (14%), Positives = 84/278 (30%), Gaps = 28/278 (10%) Query: 204 GHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTE--TGKVKTRLHLNSTPA-DVESRPTNP 260 GH+ I + + S DR++KI++ E T ++ L + V Sbjct: 16 GHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAVWCVSWAHPKY 75 Query: 261 HEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPD--GSKFISSSEDKTVR 318 + + ++ + + H +S+ + + P G +S D V Sbjct: 76 GNILASAGYDGKVLIWRELNGAWQRIFDFALHKASVNVVSWSPHEAGCLLACASSDGNVS 135 Query: 319 IWENQINVPIKQISDTAQHSMPFLNVHPS-----------------QNYFCAQSMDNRIY 361 + E + N I + ++ P+ F DN + Sbjct: 136 VLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRRFVTGGSDNALK 195 Query: 362 SFSLKPKYKRHPKKIFKGHSSAGYGISLAFSG---DGRYICSGDSKSRLFTW--DWNTSR 416 ++ P + + + +A+S YI S + W D Sbjct: 196 IWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTVRIWTSDPANPL 255 Query: 417 LLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVC 454 N + + + +V W + + SG K+ + Sbjct: 256 QWNCKVLNFDAAVWRVSWSL-SGNVLAASGGDNKVTLW 292 >4A11-B nrPDB Length = 408 Score = 130 bits (327), Expect = 1e-30, Method: Composition-based stats. Identities = 54/279 (19%), Positives = 92/279 (32%), Gaps = 43/279 (15%) Query: 161 HPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD-----YECLRDF-------QGHNKP 208 H G L P G +LSGG+D I ++D + Y C H Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 209 IKALRFTE-DCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFI--V 265 ++ +++ D F SSSFD+++K+WDT T + + T P + + V Sbjct: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAV 161 Query: 266 GLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKF-ISSSEDKTVRIWENQ- 323 G K+ D + H ILA+ + P ++S D V++W+ + Sbjct: 162 GTRGPKVQLCDLKSGS---CSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRR 218 Query: 324 --------------INVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKY 369 + ++ + + L + DNR+ ++ Sbjct: 219 ASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE 278 Query: 370 ---------KRHPKKIFKGHSSAGYGISLAFSGDGRYIC 399 + KK K S G F G I Sbjct: 279 NTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIA 317 Score = 98.0 bits (242), Expect = 8e-21, Method: Composition-based stats. Identities = 32/208 (15%), Positives = 63/208 (30%), Gaps = 27/208 (12%) Query: 135 VDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYH 194 V V R ++ GH + A+ + P+ +++ + D +K+WD Sbjct: 159 VAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRR 218 Query: 195 DYECLRDF---------------QGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGK 239 CL HN + L FT D L+ D +++W++ G+ Sbjct: 219 ASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE 278 Query: 240 VKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYD-------DRVSENQGLVQTYDHH 292 V + +F V S + + + H Sbjct: 279 NTLV-----NYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGH 333 Query: 293 LSSILALKYFPDGSKFISSSEDKTVRIW 320 ++ + + + S S D + W Sbjct: 334 YKTVDCCVFQSNFQELYSGSRDCNILAW 361 Score = 81.8 bits (200), Expect = 5e-16, Method: Composition-based stats. Identities = 36/243 (14%), Positives = 78/243 (32%), Gaps = 37/243 (15%) Query: 205 HNKPIKALRFTE-DCQSFLSSSFDRSVKIWDTETGKVKT-----------RLHLNSTPAD 252 H I L + + LS D + ++D E ++ R H + Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 253 VESRPTNPHE---FIVGLSNSKILHYDDRVSENQGLV----QTYDHHLSSILALKYFPDG 305 VE+ PH+ F + + +D + + Y HH+S + Sbjct: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKH----- 156 Query: 306 SKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPS-QNYFCAQSMDNRIYSFS 364 + V++ + + I + + ++ P S D+R+ + Sbjct: 157 CLVAVGTRGPKVQLCDLKSGSCSH-ILQGHRQEILAVSWSPRYDYILATASADSRVKLWD 215 Query: 365 LK-------PKYKRHPKKIFKGHS----SAGYGISLAFSGDGRYICSGDSKSRLFTWDWN 413 ++ + + KK S G L F+ DG ++ + + +R+ W+ + Sbjct: 216 VRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSS 275 Query: 414 TSR 416 Sbjct: 276 NGE 278 Score = 66.4 bits (160), Expect = 3e-11, Method: Composition-based stats. Identities = 22/182 (12%), Positives = 61/182 (33%), Gaps = 26/182 (14%) Query: 292 HLSSILALKYFP-DGSKFISSSEDKTVRIWENQINVPI------------KQISDTAQHS 338 H I L P +G +S D + +++ + + + D ++S Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 339 MPFLNVHP-SQNYFCAQSMDNRIYSFS---LKPKYKRHPKKIFKGHSSAGYGISLAFSGD 394 + + +P F + S D + + L+ + ++ H + Sbjct: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTK------ 155 Query: 395 GRYICSGDSKS-RLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYV 453 + + ++ ++ D + + ++ + I V W P+ + + A ++ + Sbjct: 156 -HCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQE-ILAVSWSPRYDYILATASADSRVKL 213 Query: 454 CD 455 D Sbjct: 214 WD 215 >5WYK-BB nrPDB Length = 943 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 65/399 (16%), Positives = 136/399 (34%), Gaps = 46/399 (11%) Query: 85 TQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERI 144 T D+ F + D +E G +++ + + ++ ++E Sbjct: 263 TNSSDKTSFFYIQNADKTIETFRIRKEEEIARGLKKREKRLKEKGLTEEEIAKSIKESYS 322 Query: 145 SFRCYLPKKVIRNYPGHPEGTTALKF---LPKTGHLILSGGNDHTIKIWDFY------HD 195 SF + P + IR+ + + L+L+ + +TI+ + Sbjct: 323 SFILH-PFQTIRSLY----KIKSASWTTVSSSKLELVLTTSS-NTIEYYSIPYEKRDPTS 376 Query: 196 YECLRD----FQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPA 251 L+ QG ++++ ++D + ++S S+KIW+ +T K A Sbjct: 377 PAPLKTHTIELQGQRTDVRSIDISDDNKLLATASN-GSLKIWNIKTHKCIRTF--ECGYA 433 Query: 252 DVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISS 311 I+G N ++ +D S ++ D H ++I +L DG + ++ Sbjct: 434 LTCKFLPGGLLVILGTRNGELQLFDLASSSLLDTIE--DAHDAAIWSLDLTSDGKRLVTG 491 Query: 312 SEDKTVRIWENQINVPI---------------KQISDTAQHSMPFLNVHPSQNYFCAQSM 356 S DKTV+ W+ ++ + + + + V P Y + Sbjct: 492 SADKTVKFWDFKVENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSPDDRYLAISLL 551 Query: 357 DNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSR 416 DN + F L K + +S+ S D + I + + + W + Sbjct: 552 DNTVKVFFLD-----SMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGD 606 Query: 417 LLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 ++ I V + PQ + CS + D Sbjct: 607 CHKSLFAH-QDSIMNVKFLPQSHNFFSCS-KDAVVKYWD 643 Score = 127 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 41/161 (25%), Positives = 75/161 (46%), Gaps = 7/161 (4%) Query: 162 PEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSF 221 + ++ P +L +S D+T+K++ F + GH P+ ++ + D + Sbjct: 531 TDDILCVRVSPDDRYLAISL-LDNTVKVF-FLDSMKFYLSLYGHKLPVLSIDISFDSKMI 588 Query: 222 LSSSFDRSVKIWDTETGKVKTRLHLN-STPADVESRPTNPHEFIVGLSNSKILHYDDRVS 280 ++SS D+++KIW + G L + + +V+ P + + F S ++ Y D Sbjct: 589 ITSSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQSHNFF--SCSKDAVVKYWD--G 644 Query: 281 ENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE 321 E +Q H S + AL DG +SSS D ++RIWE Sbjct: 645 EKFECIQKLYAHQSEVWALAVATDGGFVVSSSHDHSIRIWE 685 Score = 126 bits (316), Expect = 2e-29, Method: Composition-based stats. Identities = 51/312 (16%), Positives = 99/312 (31%), Gaps = 71/312 (22%) Query: 158 YPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQ-------------- 203 G ++ L+ + N ++KIW+ +C+R F+ Sbjct: 387 LQGQRTDVRSIDIS-DDNKLLATASN-GSLKIWNIKTH-KCIRTFECGYALTCKFLPGGL 443 Query: 204 ---------------------------GHNKPIKALRFTEDCQSFLSSSFDRSVKIWD-- 234 H+ I +L T D + ++ S D++VK WD Sbjct: 444 LVILGTRNGELQLFDLASSSLLDTIEDAHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFK 503 Query: 235 ---------------TETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRV 279 T L L V P + + L ++ + + Sbjct: 504 VENSLVPGTKNKFLPVLKLHHDTTLELTDDILCVRVSP-DDRYLAISLLDNTVKVFFL-- 560 Query: 280 SENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSM 339 ++ + H +L++ D I+SS DK ++IW K + Q S+ Sbjct: 561 -DSMKFYLSLYGHKLPVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKSLFA-HQDSI 618 Query: 340 PFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYIC 399 + P + F + S D + + + I K ++ +LA + DG ++ Sbjct: 619 MNVKFLPQSHNFFSCSKDAVVKYWD-----GEKFECIQKLYAHQSEVWALAVATDGGFVV 673 Query: 400 SGDSKSRLFTWD 411 S + W+ Sbjct: 674 SSSHDHSIRIWE 685 Score = 96.4 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 61/376 (16%), Positives = 122/376 (32%), Gaps = 66/376 (17%) Query: 135 VDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYH 194 + V + I + K V+ N+ GH T L+F TG ++SG D I +WD Sbjct: 94 LAVGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFD-GTGTRLISGSKDSNIIVWDLVG 152 Query: 195 DYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVE 254 + + + H I + + +S+S D +K+WD +T + ++ + Sbjct: 153 EVGLYK-LRSHKDSITGF-WCQGEDWLISTSKDGMIKLWDLKTHQCIETHIAHTG--ECW 208 Query: 255 SRPTNPHEFIVGLSNSKILHY-----DDRVSENQGLVQTYDHHLSS----ILALKYFPD- 304 I ++S++ + +D++ + ++ I + D Sbjct: 209 GLAVKDDLLITTGTDSQVKIWKLDIENDKMGGKLTEMGIFEKQSKQRGLKIEFITNSSDK 268 Query: 305 GSKFISSSEDKTVRIWENQINVPI------------------KQISDTAQHSMPFLNVHP 346 S F + DKT+ + + I ++I+ + + S +HP Sbjct: 269 TSFFYIQNADKTIETFRIRKEEEIARGLKKREKRLKEKGLTEEEIAKSIKESYSSFILHP 328 Query: 347 SQNY--------------------FCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGY- 385 Q + N I +S+ P KR P + Sbjct: 329 FQTIRSLYKIKSASWTTVSSSKLELVLTTSSNTIEYYSI-PYEKRDPTSPAPLKTHTIEL 387 Query: 386 ------GISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQET 439 S+ S D + + + L W+ T + + + + P Sbjct: 388 QGQRTDVRSIDISDDNKLLATAS-NGSLKIWNIKTHKCIRTFEC---GYALTCKFLPG-G 442 Query: 440 SKVICSGAAGKIYVCD 455 VI G++ + D Sbjct: 443 LLVILGTRNGELQLFD 458 Score = 94.5 bits (233), Expect = 8e-20, Method: Composition-based stats. Identities = 39/218 (17%), Positives = 84/218 (38%), Gaps = 28/218 (12%) Query: 218 CQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTP------------ADVESRPTNPHEFIV 265 Q S+ D V IWD +TG + ++L P + V Sbjct: 39 GQLITSALED--VNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLAV 96 Query: 266 GLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQIN 325 G ++ I +D ++ ++ ++ H ++I L++ G++ IS S+D + +W+ Sbjct: 97 GYADGVIKVWDLM---SKTVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIVWDLVGE 153 Query: 326 VPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGY 385 V + ++ + + S+ +++ + S D I + LK I + G Sbjct: 154 VGLYKL-RSHKDSITGF-WCQGEDWLISTSKDGMIKLWDLKTHQC-----IETHIAHTGE 206 Query: 386 GISLAFSGDGRYICSGDSKSRLFTW--DWNTSRLLNNI 421 LA D + + + S++ W D ++ + Sbjct: 207 CWGLAVKDD--LLITTGTDSQVKIWKLDIENDKMGGKL 242 Score = 93.7 bits (231), Expect = 2e-19, Method: Composition-based stats. Identities = 34/152 (22%), Positives = 55/152 (36%), Gaps = 7/152 (4%) Query: 173 KTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKI 232 K L+ G D IK+WD L +F GH I L+F +S S D ++ + Sbjct: 89 KDTDLLAVGYADGVIKVWDLMSK-TVLLNFNGHKAAITLLQFDGTGTRLISGSKDSNIIV 147 Query: 233 WDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHH 292 WD +L + I + I +D + + ++T+ H Sbjct: 148 WDLVGEVGLYKLRSHKDSI-TGFWCQGEDWLISTSKDGMIKLWDLKTHQ---CIETHIAH 203 Query: 293 LSSILALKYFPDGSKFISSSEDKTVRIWENQI 324 L D I++ D V+IW+ I Sbjct: 204 TGECWGLAVKDD--LLITTGTDSQVKIWKLDI 233 Score = 86.8 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 26/147 (17%), Positives = 54/147 (36%), Gaps = 2/147 (1%) Query: 135 VDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYH 194 + + L + + K + GH ++ +I++ D IKIW Sbjct: 546 LAISLLDNTVKVFFLDSMKFYLSLYGHKLPVLSIDIS-FDSKMIITSSADKNIKIWGLDF 604 Query: 195 DYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVE 254 +C + H I ++F +F S S D VK WD E + +L+ + + Sbjct: 605 G-DCHKSLFAHQDSIMNVKFLPQSHNFFSCSKDAVVKYWDGEKFECIQKLYAHQSEVWAL 663 Query: 255 SRPTNPHEFIVGLSNSKILHYDDRVSE 281 + T+ + + I +++ + Sbjct: 664 AVATDGGFVVSSSHDHSIRIWEETEDQ 690 Score = 48.7 bits (114), Expect = 5e-06, Method: Composition-based stats. Identities = 18/113 (15%), Positives = 32/113 (28%), Gaps = 7/113 (6%) Query: 348 QNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSA-----GYGISLAFSGDGRYICSGD 402 + D I+ + + G S A L D + G Sbjct: 39 GQLITSALEDVNIWDIKTGDLVSKLSDGLPPGASDARGAKPAECTYLEAHKDTDLLAVGY 98 Query: 403 SKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 + + WD + +L N IT + + +++I I V D Sbjct: 99 ADGVIKVWDLMSKTVLLNFNGH-KAAITLLQFDGT-GTRLISGSKDSNIIVWD 149 >3JRO-A nrPDB Length = 753 Score = 128 bits (321), Expect = 5e-30, Method: Composition-based stats. Identities = 47/277 (16%), Positives = 96/277 (34%), Gaps = 28/277 (10%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD-YECLRDFQGHNKPIKALRFTED- 217 H E L G + + +D TIKI++ + ++ + GH P+ + + Sbjct: 7 AHNELIHD-AVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 Query: 218 -CQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHE----FIVGLSNSKI 272 S S+D V IW E G+ A V S PHE +V S+ K+ Sbjct: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125 Query: 273 LHYDDRVSENQGLVQTYDHHLSSILALKYFP-------------DGSKFISSSEDKTVRI 319 + + + + D H + + + P + KF++ D V+I Sbjct: 126 SVVEFKENGTTSPI-IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 184 Query: 320 WENQIN---VPIKQISDTAQHSMPFLNVHPS---QNYFCAQSMDNRIYSFSLKPKYKRHP 373 W+ + ++ + + + P+ ++Y + S D ++ + Sbjct: 185 WKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWK 244 Query: 374 KKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTW 410 K + K ++S G + +++ W Sbjct: 245 KTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 118 bits (296), Expect = 5e-27, Method: Composition-based stats. Identities = 37/238 (15%), Positives = 85/238 (35%), Gaps = 27/238 (11%) Query: 153 KVIRNYPGHPEGTTALKF-LPKTGHLILSGGNDHTIKIWDFYHD-YECLRDFQGHNKPIK 210 K+I GH + + PK G ++ S D + IW + + + H+ + Sbjct: 44 KLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVN 103 Query: 211 ALRFTED--CQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNP-------- 260 ++++ L +S D V + + + + + +++ V S P Sbjct: 104 SVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGE 163 Query: 261 -------HEFIVGLSNSKILHYDDRVSENQGLV-QTYDHHLSSILALKYFPDG---SKFI 309 +F+ G +++ + + ++ T + H + + + P S Sbjct: 164 HNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLA 223 Query: 310 SSSEDKTVRIW--ENQINVPIKQISDTAQ--HSMPFLNVHPSQNYFCAQSMDNRIYSF 363 S S+D+T IW +N+ K + + + + S N DN++ + Sbjct: 224 SVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 98.4 bits (243), Expect = 6e-21, Method: Composition-based stats. Identities = 42/277 (15%), Positives = 89/277 (32%), Gaps = 28/277 (10%) Query: 204 GHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTE--TGKVKTRLHLNSTPA-DVESRPTNP 260 HN+ I + + S D+++KI++ E T K+ L + P V+ Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 261 HEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPD--GSKFISSSEDKTVR 318 + S + + + + H +S+ ++++ P G + +S D V Sbjct: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 Query: 319 IWENQINVPIK-QISDTAQHSMPFLNVHP-----SQNY--------FCAQSMDNRIYSFS 364 + E + N I D + + P + F DN + + Sbjct: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 Query: 365 LKPKYKRHPKK-IFKGHSSAGYGISLAFSGD---GRYICSGDSKSRLFTWDWNTSRLLNN 420 + + + +GHS + +A+S Y+ S W + + Sbjct: 187 YNSDAQTYVLESTLEGHSD--WVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWK 244 Query: 421 IKIPGNKPITQVDWHPQ---ETSKVICSGAAGKIYVC 454 + + V W + + SG K+ + Sbjct: 245 KTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 >5WLC-LU nrPDB Length = 489 Score = 126 bits (316), Expect = 2e-29, Method: Composition-based stats. Identities = 59/325 (18%), Positives = 112/325 (34%), Gaps = 44/325 (13%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFT---- 215 GH +G A+ + + + +G D IK W+ E + F+ H + L T Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFV-SFKAHYGLVTGLCVTQPRF 123 Query: 216 -------EDCQSFLSSSFDRSVKIWD-----------------TETGKVKTRLHLNSTPA 251 + LS S D++VK+W T + S Sbjct: 124 HDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGLIRTFDGESAFQ 183 Query: 252 DVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPD-GSKFIS 310 ++S N F G + KI +D V +I +LK+ + S Sbjct: 184 GIDSHREN-STFATGGA--KIHLWDV---NRLKPVSDLSWGADNITSLKFNQNETDILAS 237 Query: 311 SSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNY-FCAQSMDNRIYSFSLKPKY 369 + D ++ +++ + N P ++I T + + +P + + F + D+ Y + ++ Sbjct: 238 TGSDNSIVLYDLRTNSPTQKIVQTMR--TNAICWNPMEAFNFVTANEDHNAYYYDMRNLS 295 Query: 370 KRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPI 429 +FK H SA + FS G I +G + + N + + Sbjct: 296 --RSLNVFKDHVSAVM--DVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIYHTKRMQHV 351 Query: 430 TQVDWHPQETSKVICSGAAGKIYVC 454 QV + +I G + + Sbjct: 352 FQVKYSMDS-KYIISGSDDGNVRLW 375 Score = 110 bits (274), Expect = 2e-24, Method: Composition-based stats. Identities = 49/350 (14%), Positives = 108/350 (30%), Gaps = 73/350 (20%) Query: 100 DNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPPN-----DVDVDLREERISFRCYLPKKV 154 L++ ++E F G+ ++ Y N + + I + ++ Sbjct: 43 KALNATKLERMFAKPFVGQLGYGHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREE 102 Query: 155 IRNYPGHPEGTTALKFL--------PK--TGHLILSGGNDHTIKIWDF------------ 192 ++ H T L P + + +LS +D T+K+W Sbjct: 103 FVSFKAHYGLVTGLCVTQPRFHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSD 162 Query: 193 ----YHDYECLRDFQG---------HN--------------------KPIKALRFTEDC- 218 ++ +R F G H KP+ L + D Sbjct: 163 NDSVTNEEGLIRTFDGESAFQGIDSHRENSTFATGGAKIHLWDVNRLKPVSDLSWGADNI 222 Query: 219 ----------QSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLS 268 S+ D S+ ++D T ++ + P F+ Sbjct: 223 TSLKFNQNETDILASTGSDNSIVLYDLRTNSPTQKIVQTMRTNAICWNPMEAFNFVTANE 282 Query: 269 NSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPI 328 + +YD R + + H+S+++ + + P G + ++ S DK++RI++ Sbjct: 283 DHNAYYYDMRNLS--RSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSR 340 Query: 329 KQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFK 378 + + + Y + S D + + K + + K + Sbjct: 341 EIYHTKRMQHVFQVKYSMDSKYIISGSDDGNVRLWRSKAWERSNVKTTRE 390 >5WJC-A nrPDB Length = 430 Score = 125 bits (313), Expect = 5e-29, Method: Composition-based stats. Identities = 46/251 (18%), Positives = 93/251 (37%), Gaps = 36/251 (14%) Query: 144 ISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD-------- 195 ++ LP+ V++ GH L + P + +G D I +WD Sbjct: 167 LTTGEALPQAVLK---GHTAEGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETK 223 Query: 196 -YECLRDFQGHNKPIKALRFTEDCQ-SFLSSSFDRSVKIWDTETGKVK---TRLHLNSTP 250 + + H + ++F + S S D +++I DT + + +S Sbjct: 224 VISPIAKYHRHTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKA 283 Query: 251 AD-VESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFP-DGSKF 308 + V P N + ++ + +D R + + T + H + L++ P D Sbjct: 284 INAVAINPFNDYLLATASADKTVALWDLRNPYQR--LHTLEGHEDEVYGLEWSPHDEPIL 341 Query: 309 ISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNV--------------HPSQNYFC-A 353 SSS D+ V IW+ + + +Q + A+ P L P++ + + Sbjct: 342 ASSSTDRRVCIWDLE-KIGEEQTPEDAEDGSPELLFMHGGHTNRISEFSWCPNERWVVGS 400 Query: 354 QSMDNRIYSFS 364 + DN + +S Sbjct: 401 LADDNILQIWS 411 Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats. Identities = 44/340 (12%), Positives = 103/340 (30%), Gaps = 40/340 (11%) Query: 111 EVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYP---------GH 161 + + + YL + + E+ F ++ H Sbjct: 71 SIQRLILGTHTSGNDQNYLQIASVQLPNFDEDTTEFTPSTIRRAQATGSYTIEISQKIPH 130 Query: 162 PEGTTALKFLPKTGHLILSGGNDHTIKIWD------FYHDYE-CLRDFQGHNKPIKALRF 214 +++P+ +I + G I+D +GH L + Sbjct: 131 DGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLCW 190 Query: 215 TED-CQSFLSSSFDRSVKIWDTETGKVKTR-----------LHLNSTPADVESRPTNPHE 262 + + + + D+ + +WD +T + DV+ P + Sbjct: 191 NPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEAL 250 Query: 263 FIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFP-DGSKFISSSEDKTVRIWE 321 + + +D R++ + + H +I A+ P + ++S DKTV +W+ Sbjct: 251 LASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALWD 310 Query: 322 NQINVPIKQISDTAQHSMPFLNVHP-SQNYFCAQSMDNRIYSFSL---------KPKYKR 371 + + + + L P + + S D R+ + L + Sbjct: 311 LRNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDG 370 Query: 372 HPKKIFKGHSSAGYGISLAFSGDGRYIC-SGDSKSRLFTW 410 P+ +F ++ + R++ S + L W Sbjct: 371 SPELLFMHGGHTNRISEFSWCPNERWVVGSLADDNILQIW 410 Score = 118 bits (295), Expect = 5e-27, Method: Composition-based stats. Identities = 40/213 (18%), Positives = 72/213 (33%), Gaps = 37/213 (17%) Query: 110 EEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALK 169 +D + + + R++ PK H + A+ Sbjct: 233 RHTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPK----VIQAHSKAINAVA 288 Query: 170 FLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTE-DCQSFLSSSFDR 228 P +L+ + D T+ +WD + Y+ L +GH + L ++ D SSS DR Sbjct: 289 INPFNDYLLATASADKTVALWDLRNPYQRLHTLEGHEDEVYGLEWSPHDEPILASSSTDR 348 Query: 229 SVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQT 288 V IWD E ++ TP D E + L+ Sbjct: 349 RVCIWDLE------KIGEEQTPEDAE-------------------------DGSPELLFM 377 Query: 289 YDHHLSSILALKYFPDGSKFI-SSSEDKTVRIW 320 + H + I + P+ + S ++D ++IW Sbjct: 378 HGGHTNRISEFSWCPNERWVVGSLADDNILQIW 410 Score = 105 bits (261), Expect = 4e-23, Method: Composition-based stats. Identities = 43/285 (15%), Positives = 92/285 (32%), Gaps = 39/285 (13%) Query: 205 HNKPIKALRFTEDC-QSFLSSSFDRSVKIWDT---------ETGKVKTRLHLNSTPADVE 254 H+ + R+ + + + I+DT E + + Sbjct: 130 HDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLC 189 Query: 255 SRPTNPHEFIVGLSNSKILHYDDRV-------SENQGLVQTYDHHLSSILALKYFP-DGS 306 P P G + I +D + ++ + Y H + +++ P + Sbjct: 190 WNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEA 249 Query: 307 KFISSSEDKTVRIWENQIN--VPIKQISDTAQHSMPFLNVHP-SQNYFCAQSMDNRIYSF 363 S S+D T++I + ++N ++ ++ + ++P + S D + + Sbjct: 250 LLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALW 309 Query: 364 SLKPKYKRHPKKIFKGHSSAGYGISLAFSG-DGRYICSGDSKSRLFTWDWNT-------- 414 L+ Y+R +GH YG+ +S D + S + R+ WD Sbjct: 310 DLRNPYQR--LHTLEGHEDEVYGLE--WSPHDEPILASSSTDRRVCIWDLEKIGEEQTPE 365 Query: 415 -----SRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVC 454 S L + I++ W P E V + + Sbjct: 366 DAEDGSPELLFMHGGHTNRISEFSWCPNERWVVGSLADDNILQIW 410 Score = 93.3 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 29/234 (12%), Positives = 74/234 (31%), Gaps = 19/234 (8%) Query: 239 KVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDR-----VSENQGLVQTYDHHL 293 ++ ++ + P P +D + H Sbjct: 123 EISQKIPHDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHT 182 Query: 294 SSILALKYFPDGS-KFISSSEDKTVRIWENQIN-------VPIKQISDTAQH--SMPFLN 343 + L + P+ + +ED+ + +W+ Q I I+ +H + + Sbjct: 183 AEGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQ 242 Query: 344 VHPSQN-YFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGD 402 HP + S D + + + K+ + HS A +++ D + + Sbjct: 243 FHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFND-YLLATAS 301 Query: 403 SKSRLFTWDWNTS-RLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 + + WD + L+ ++ + ++W P + + S ++ + D Sbjct: 302 ADKTVALWDLRNPYQRLHTLEGH-EDEVYGLEWSPHDEPILASSSTDRRVCIWD 354 >4L9O-A nrPDB Length = 349 Score = 124 bits (312), Expect = 6e-29, Method: Composition-based stats. Identities = 46/269 (17%), Positives = 89/269 (33%), Gaps = 20/269 (7%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFY-HDYECLRDFQGHNKPIKALRFTED- 217 H + L G + + +D TIKI++ + + GH P+ + + Sbjct: 67 AHDDLIHD-AVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPK 125 Query: 218 -CQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHE----FIVGLSNSKI 272 S S+D V IW + G + A V S PHE + S+ KI Sbjct: 126 FGVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKI 185 Query: 273 LHYDDRVSENQGLVQTYDHHLSSILALKYFP-----DGSKFISSSEDKTVRIW---ENQI 324 + + + H + A + P + +F+S D V+IW + Sbjct: 186 SIVEFKDGGALEPI-VIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAK 244 Query: 325 NVPIKQISDTAQHSMPFLNVHPSQ---NYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHS 381 ++ + + PS+ +Y S D + ++ K + K+ Sbjct: 245 TFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEK 304 Query: 382 SAGYGISLAFSGDGRYICSGDSKSRLFTW 410 ++S G + +++ W Sbjct: 305 FPDVCWRASWSLSGNVLAISGGDNKVTLW 333 Score = 113 bits (282), Expect = 2e-25, Method: Composition-based stats. Identities = 44/261 (16%), Positives = 93/261 (35%), Gaps = 24/261 (9%) Query: 122 DYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKF-LPKTGHLILS 180 DY GR +D + + E ++++ GH + + PK G ++ S Sbjct: 78 DYYGRRLATCSSDKTIKIFEIDGE-----NQRLVETLIGHEGPVWQVAWAHPKFGVILAS 132 Query: 181 GGNDHTIKIWDFYHD-YECLRDFQGHNKPIKALRFTED--CQSFLSSSFDRSVKIWDTET 237 D + IW + + + + H + ++ + L +S D + I + + Sbjct: 133 CSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKISIVEFKD 192 Query: 238 GKVKTRLHLNSTPADVE-------SRPTNPHEFIVGLSNSKILHYD-DRVSENQGLVQTY 289 G + + V S P N F+ G ++ + + D ++ + + Sbjct: 193 GGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTFIEEEAF 252 Query: 290 DHHLSSILALKYFP---DGSKFISSSEDKTVRIW--ENQINVPIKQISDTAQ--HSMPFL 342 H + + + P S ++S+D+TV IW + + N KQ + Sbjct: 253 QGHSDWVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVCWRA 312 Query: 343 NVHPSQNYFCAQSMDNRIYSF 363 + S N DN++ + Sbjct: 313 SWSLSGNVLAISGGDNKVTLW 333 Score = 97.2 bits (240), Expect = 1e-20, Method: Composition-based stats. Identities = 40/269 (14%), Positives = 87/269 (32%), Gaps = 20/269 (7%) Query: 204 GHNKPIKALRFTEDCQSFLSSSFDRSVKIW--DTETGKVKTRLHLNSTPA-DVESRPTNP 260 H+ I + + S D+++KI+ D E ++ L + P V Sbjct: 67 AHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKF 126 Query: 261 HEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPD--GSKFISSSEDKTVR 318 + S + + V + H +S+ ++ + P G + +S D + Sbjct: 127 GVILASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKIS 186 Query: 319 IWENQINVPIK-QISDTAQHSMPFLNVHP-----SQNYFCAQSMDNRIYSFSLKPKYKRH 372 I E + ++ + + + P + F + DN + + K Sbjct: 187 IVEFKDGGALEPIVIQGHAIGVNAASWAPISLPDNTRRFVSGGCDNLVKIWRYDDAAKTF 246 Query: 373 -PKKIFKGHSSAGYGISLAFSG---DGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKP 428 ++ F+GHS + +A+S YI + + W + + + Sbjct: 247 IEEEAFQGHSD--WVRDVAWSPSRLSKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEK 304 Query: 429 ITQVDWHPQ---ETSKVICSGAAGKIYVC 454 V W + + SG K+ + Sbjct: 305 FPDVCWRASWSLSGNVLAISGGDNKVTLW 333 Score = 68.7 bits (166), Expect = 5e-12, Method: Composition-based stats. Identities = 32/197 (16%), Positives = 62/197 (31%), Gaps = 9/197 (4%) Query: 266 GLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQI- 324 G S +I G V + H I G + + S DKT++I+E Sbjct: 42 GQSKVEINIVGSGGGSGGGSVTIGNAHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGE 101 Query: 325 NVPIKQISDTAQHSMPFLNV-HPS-QNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSS 382 N + + + + + HP + S D ++ + H + Sbjct: 102 NQRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVLIWKEDNGVWNK-VAEHSVHQA 160 Query: 383 AGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNK-PITQVDWH----PQ 437 + +S A G + S ++ ++ L I I G+ + W P Sbjct: 161 SVNSVSWAPHEYGPVLLCASSDGKISIVEFKDGGALEPIVIQGHAIGVNAASWAPISLPD 220 Query: 438 ETSKVICSGAAGKIYVC 454 T + + G + + Sbjct: 221 NTRRFVSGGCDNLVKIW 237 >4J0W-A nrPDB Length = 343 Score = 124 bits (310), Expect = 1e-28, Method: Composition-based stats. Identities = 44/263 (16%), Positives = 83/263 (31%), Gaps = 20/263 (7%) Query: 159 PGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDC 218 PGH + G + SG I IW+ + L F GH + L F Sbjct: 64 PGHSSHVLCMAISSD-GKYLASGDRSKLILIWE-AQSCQHLYTFTGHRDAVSGLAFRRGT 121 Query: 219 QSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDR 278 S+S DRSVK+W+ L + + G + + + Sbjct: 122 HQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIP 181 Query: 279 VSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHS 338 + H SI + + +S ++D +V +W P+ + Sbjct: 182 EESQL----VFYGHQGSIDCIHLINE-EHMVSGADDGSVALWGLSKKRPLALQREAHGLR 236 Query: 339 ----------MPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGIS 388 + + + + S + + + +++ + G+ S Sbjct: 237 GEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQ--LDLLCDIPLVGFINS 294 Query: 389 LAFSGDGRYICSG-DSKSRLFTW 410 L FS G ++ +G + RL W Sbjct: 295 LKFSSSGDFLVAGVGQEHRLGRW 317 Score = 114 bits (285), Expect = 8e-26, Method: Composition-based stats. Identities = 48/319 (15%), Positives = 102/319 (31%), Gaps = 27/319 (8%) Query: 155 IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDF-----------Q 203 IR GH T L P I S D +I W + L Sbjct: 7 IRVLRGHQLSITCLVVTPDD-SAIFSAAKDCSIIKWSVESGRK-LHVIPRAKKGAEGKPP 64 Query: 204 GHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEF 263 GH+ + + + D + S + + IW+ ++ + + + H+ Sbjct: 65 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 124 Query: 264 IVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQ 323 + + ++ + V+T H ++ AL + D TVR+W + Sbjct: 125 YSTSHDRSVKVWNVAENSY---VETLFGHQDAVAALDALSRECCVTAGGRDGTVRVW--K 179 Query: 324 INVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFS------LKPKYKRHPKKIF 377 I + + Q S+ +++ ++ + + + D + + L + + H + Sbjct: 180 IPEESQLVFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGE 238 Query: 378 KGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTS--RLLNNIKIPGNKPITQVDWH 435 G + S+A + + +G S + W +L IP I + + Sbjct: 239 PGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPLVGFINSLKFS 298 Query: 436 PQETSKVICSGAAGKIYVC 454 V G ++ Sbjct: 299 SSGDFLVAGVGQEHRLGRW 317 Score = 61.0 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 27/133 (20%), Positives = 55/133 (41%), Gaps = 12/133 (9%) Query: 331 ISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLK--------PKYKRHPKKIFKGHSS 382 + Q S+ L V P + + + D I +S++ P+ K+ + GHSS Sbjct: 9 VLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSS 68 Query: 383 AGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKV 442 + + +A S DG+Y+ SGD + W+ + + L G++ + T ++ Sbjct: 69 --HVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTF--TGHRDAVSGLAFRRGTHQL 124 Query: 443 ICSGAAGKIYVCD 455 + + V + Sbjct: 125 YSTSHDRSVKVWN 137 >4AEZ-A nrPDB Length = 401 Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats. Identities = 47/292 (16%), Positives = 106/292 (36%), Gaps = 19/292 (6%) Query: 168 LKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFD 227 L + +++ + + +W+ + + +++++ D + Sbjct: 99 LDWSNLN---VVAVALERNVYVWNADSGSVSALAETDESTYVASVKWSHDGSFLSVGLGN 155 Query: 228 RSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQ 287 V I+D E+ + + A V N H G + I H+D R++ +Q + Sbjct: 156 GLVDIYDVESQTKLRTMAGHQ--ARVGCLSWNRHVLSSGSRSGAIHHHDVRIANHQ--IG 211 Query: 288 TYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPS 347 T H S + L + DG + S D V+IW+ + ++P ++ + P Sbjct: 212 TLQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFT-KTNHNAAVKAVAWCPW 270 Query: 348 QNYFCA---QSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICS--GD 402 Q+ A +MD +I+ ++ + + + SL +S + I S G Sbjct: 271 QSNLLATGGGTMDKQIHFWNAATGARVNTV------DAGSQVTSLIWSPHSKEIMSTHGF 324 Query: 403 SKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVC 454 + L W +++S L + IP + + + + + + Sbjct: 325 PDNNLSIWSYSSSGLTKQVDIPAHDTRVLYSALSPDGRILSTAASDENLKFW 376 Score = 111 bits (278), Expect = 5e-25, Method: Composition-based stats. Identities = 40/230 (17%), Positives = 71/230 (30%), Gaps = 15/230 (6%) Query: 151 PKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIK 210 + +R GH L + H++ SG I D + QGH+ + Sbjct: 165 SQTKLRTMAGHQARVGCLSW---NRHVLSSGSRSGAIHHHDVRIANHQIGTLQGHSSEVC 221 Query: 211 ALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPAD-VESRPTNPHEFIVGLS- 268 L + D S D V+IWD + K ++ V P + G Sbjct: 222 GLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGT 281 Query: 269 -NSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFIS--SSEDKTVRIWENQIN 325 + +I ++ V S + +L + P + +S D + IW + Sbjct: 282 MDKQIHFWNAATGARVNTVDA----GSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSS 337 Query: 326 VPIKQISDTAQHSMPFL--NVHPSQNYFCAQSMDNRIYSFSLKPKYKRHP 373 KQ+ D H L + P + D + + + Sbjct: 338 GLTKQV-DIPAHDTRVLYSALSPDGRILSTAASDENLKFWRVYDGDHVKR 386 Score = 110 bits (274), Expect = 1e-24, Method: Composition-based stats. Identities = 46/299 (15%), Positives = 95/299 (31%), Gaps = 19/299 (6%) Query: 56 LKRRRKTRKGDGPWGSWSSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHF 115 L+R D S + DE++ + + F+ ++ N + +VE + Sbjct: 111 LERNVYVWNADSGSVSALAETDESTYVASVKWSHDGSFL-SVGLGNGLVDIYDVESQTKL 169 Query: 116 YGKSEKDYQGR-------GYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTAL 168 + +Q R ++ + + + I GH L Sbjct: 170 R--TMAGHQARVGCLSWNRHVLSSGSRSGAIHHHDVRIANHQ----IGTLQGHSSEVCGL 223 Query: 169 KFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLS---SS 225 + G + SGGND+ ++IWD HN +KA+ + + L+ + Sbjct: 224 AWRSD-GLQLASGGNDNVVQIWDARSSI-PKFTKTNHNAAVKAVAWCPWQSNLLATGGGT 281 Query: 226 FDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGL 285 D+ + W+ TG + S + P + L S Sbjct: 282 MDKQIHFWNAATGARVNTVDAGSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTK 341 Query: 286 VQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNV 344 H + +L PDG +++ D+ ++ W +K+ + + + Sbjct: 342 QVDIPAHDTRVLYSALSPDGRILSTAASDENLKFWRVYDGDHVKRPIPITKTPSSSITI 400 Score = 84.9 bits (208), Expect = 6e-17, Method: Composition-based stats. Identities = 33/187 (17%), Positives = 74/187 (39%), Gaps = 12/187 (6%) Query: 271 KILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQ 330 + ++ L +T + + + ++K+ DGS + V I++ + ++ Sbjct: 114 NVYVWNADSGSVSALAETDE--STYVASVKWSHDGSFLSVGLGNGLVDIYDVESQTKLRT 171 Query: 331 ISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLA 390 + A H + +++ + S I+ ++ H +GHSS LA Sbjct: 172 M---AGHQARVGCLSWNRHVLSSGSRSGAIHHHDVRIA--NHQIGTLQGHSSEV--CGLA 224 Query: 391 FSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGA--A 448 + DG + SG + + + WD +S + K N + V W P +++ + G Sbjct: 225 WRSDGLQLASGGNDNVVQIWDARSS-IPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMD 283 Query: 449 GKIYVCD 455 +I+ + Sbjct: 284 KQIHFWN 290 Score = 30.9 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 6/58 (10%), Positives = 22/58 (37%), Gaps = 1/58 (1%) Query: 398 ICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 + + + ++ W+ ++ + + + + V W + S + G + + D Sbjct: 106 VVAVALERNVYVWNADSGSVSALAETDESTYVASVKWS-HDGSFLSVGLGNGLVDIYD 162 >5FA5-B nrPDB Length = 367 Score = 123 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 38/206 (18%), Positives = 80/206 (38%), Gaps = 13/206 (6%) Query: 161 HPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQS 220 H + + + L +G +SG D IK+WD L ++ H + + + S Sbjct: 149 HDDIVSTVSVLS-SGTQAVSGSKDICIKVWDLAQQV-VLSSYRAHAAQVTCVAASPHKDS 206 Query: 221 -FLSSSFDRSVKIWDTETGKVKTRLHLNST---PADVESRPTNPHEFIVGLSNSKILHYD 276 FLS S D + +WDT K +++ ++ P + P F+ G N + D Sbjct: 207 VFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVD 266 Query: 277 DRVSENQGLVQTYDHHLSSILALKYFPDG-SKFISSSEDKTVRIWENQINVPIKQISDTA 335 + + V + H + L + P S SED ++ + ++ ++ + + Sbjct: 267 TKSTS---CVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQA--H 321 Query: 336 QHSMPFLNVHP-SQNYFCAQSMDNRI 360 + + P + + D+++ Sbjct: 322 RDFVRDATWSPLNHSLLTTVGWDHQV 347 Score = 82.2 bits (201), Expect = 5e-16, Method: Composition-based stats. Identities = 33/225 (14%), Positives = 76/225 (33%), Gaps = 14/225 (6%) Query: 236 ETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTY--DHHL 293 G + + AD+ +V + + ++ +E +V + H Sbjct: 94 NEGFCSAGVQTEAGVADLTWV--GERGILVASDSGAVELWELDENETL-IVSKFCKYEHD 150 Query: 294 SSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHP-SQNYFC 352 + + G++ +S S+D +++W+ V + + + P + F Sbjct: 151 DIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSY-RAHAAQVTCVAASPHKDSVFL 209 Query: 353 AQSMDNRIYSFSLK-PKYKRHPKKIFKGHSSAGYGISLAFSG-DGRYICSGDSKSRLFTW 410 + S DNRI + + PK G+ SLA+ GD + Sbjct: 210 SCSEDNRILLWDTRCPKPASQIGCSAPGYLP----TSLAWHPQQSEVFVFGDENGTVSLV 265 Query: 411 DWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 D ++ + + + ++ +T + + P + + V D Sbjct: 266 DTKSTSCVLSSAVH-SQCVTGLVFSPHSVPFLASLSEDCSLAVLD 309 Score = 74.5 bits (181), Expect = 9e-14, Method: Composition-based stats. Identities = 31/185 (16%), Positives = 60/185 (32%), Gaps = 12/185 (6%) Query: 141 EERISFRCYLPKK--VIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYEC 198 + I + + + V+ +Y H T + P + LS D+ I +WD Sbjct: 169 SKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPA 228 Query: 199 LRDFQGHNKP---IKALRFTE-DCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVE 254 + G + P +L + + F+ + +V + DT++ ++S Sbjct: 229 SQI--GCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGL 286 Query: 255 SRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFP-DGSKFISSSE 313 + F+ LS L D Q H + + P + S + Sbjct: 287 VFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQA---HRDFVRDATWSPLNHSLLTTVGW 343 Query: 314 DKTVR 318 D V Sbjct: 344 DHQVV 348 >3JRP-A nrPDB Length = 379 Score = 121 bits (304), Expect = 6e-28, Method: Composition-based stats. Identities = 47/277 (16%), Positives = 96/277 (34%), Gaps = 28/277 (10%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD-YECLRDFQGHNKPIKALRFTED- 217 H E L G + + +D TIKI++ + ++ + GH P+ + + Sbjct: 9 AHNELIHD-AVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 67 Query: 218 -CQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHE----FIVGLSNSKI 272 S S+D V IW E G+ A V S PHE +V S+ K+ Sbjct: 68 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 127 Query: 273 LHYDDRVSENQGLVQTYDHHLSSILALKYFP-------------DGSKFISSSEDKTVRI 319 + + + + D H + + + P + KF++ D V+I Sbjct: 128 SVVEFKENGTTSPI-IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 186 Query: 320 WENQIN---VPIKQISDTAQHSMPFLNVHPS---QNYFCAQSMDNRIYSFSLKPKYKRHP 373 W+ + ++ + + + P+ ++Y + S D ++ + Sbjct: 187 WKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWK 246 Query: 374 KKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTW 410 K + K ++S G + +++ W Sbjct: 247 KTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 283 Score = 112 bits (279), Expect = 4e-25, Method: Composition-based stats. Identities = 37/238 (15%), Positives = 85/238 (35%), Gaps = 27/238 (11%) Query: 153 KVIRNYPGHPEGTTALKF-LPKTGHLILSGGNDHTIKIWDFYHD-YECLRDFQGHNKPIK 210 K+I GH + + PK G ++ S D + IW + + + H+ + Sbjct: 46 KLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVN 105 Query: 211 ALRFTED--CQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNP-------- 260 ++++ L +S D V + + + + + +++ V S P Sbjct: 106 SVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGE 165 Query: 261 -------HEFIVGLSNSKILHYDDRVSENQGLV-QTYDHHLSSILALKYFPDG---SKFI 309 +F+ G +++ + + ++ T + H + + + P S Sbjct: 166 HNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLA 225 Query: 310 SSSEDKTVRIW--ENQINVPIKQISDTAQ--HSMPFLNVHPSQNYFCAQSMDNRIYSF 363 S S+D+T IW +N+ K + + + + S N DN++ + Sbjct: 226 SVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 283 Score = 92.2 bits (227), Expect = 4e-19, Method: Composition-based stats. Identities = 42/277 (15%), Positives = 89/277 (32%), Gaps = 28/277 (10%) Query: 204 GHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTE--TGKVKTRLHLNSTPA-DVESRPTNP 260 HN+ I + + S D+++KI++ E T K+ L + P V+ Sbjct: 9 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 68 Query: 261 HEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPD--GSKFISSSEDKTVR 318 + S + + + + H +S+ ++++ P G + +S D V Sbjct: 69 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 128 Query: 319 IWENQINVPI-KQISDTAQHSMPFLNVHPS-------------QNYFCAQSMDNRIYSFS 364 + E + N I D + + P+ F DN + + Sbjct: 129 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 188 Query: 365 LKPKYKRHPKK-IFKGHSSAGYGISLAFSGD---GRYICSGDSKSRLFTWDWNTSRLLNN 420 + + + +GHS + +A+S Y+ S W + + Sbjct: 189 YNSDAQTYVLESTLEGHSD--WVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWK 246 Query: 421 IKIPGNKPITQVDWHPQ---ETSKVICSGAAGKIYVC 454 + + V W + + SG K+ + Sbjct: 247 KTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 283 >5L9T-R nrPDB Length = 493 Score = 121 bits (303), Expect = 7e-28, Method: Composition-based stats. Identities = 64/337 (18%), Positives = 120/337 (35%), Gaps = 27/337 (8%) Query: 94 VHALAEDNLDSEQIEVEEVSHFYGK--SEKDYQGRGYLYPPNDVDVDLREERISFRCYLP 151 V ++ L S + ++S K + Q YL + +++ + YL Sbjct: 153 VSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLW 212 Query: 152 KKV------IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGH 205 + + + T++ + + G+L+ G + ++IWD + L +GH Sbjct: 213 SACTSQVTRLCDLSVEGDSVTSVGWS-ERGNLVAVGTHKGFVQIWDAAAG-KKLSMLEGH 270 Query: 206 NKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTN-PHEFI 264 + AL + + S S DR + D T +++ L +V + H+ + Sbjct: 271 TARVGALAWN--AEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLL 328 Query: 265 VGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGS-KFISSS--EDKTVRIWE 321 N L + S + VQ Y HL+++ A+ + P S D+ +R W Sbjct: 329 ASGGNDNKLLVWNHSSLSP--VQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWN 386 Query: 322 NQINVPIKQISDTAQHSMPFLNVHPSQNYFCA--QSMDNRIYSFSLKPKYKRHPKKIFKG 379 P++ I +Q + L N + N+I + G Sbjct: 387 TLTGQPLQCIDTGSQ--VCNLAWSKHANELVSTHGYSQNQILVW---KYPSLTQVAKLTG 441 Query: 380 HSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSR 416 HS + LA S DG I +G L W+ + Sbjct: 442 HSYRV--LYLAMSPDGEAIVTGAGDETLRFWNVFSKT 476 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 57/384 (14%), Positives = 124/384 (32%), Gaps = 37/384 (9%) Query: 86 QKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQ-----GRGYLYPPNDVDVDLR 140 Q ED+ + + L + + + S G Y + + + Sbjct: 111 QTEDRRLQPSTPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRK 170 Query: 141 EERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYE--- 197 +I F+ ++ ++ + + +LS G + +W Sbjct: 171 ISKIPFKVLDAPELQDDFY-----LNLVDWSSLN---VLSVGLGTCVYLWSACTSQVTRL 222 Query: 198 CLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRP 257 C +G + ++ ++E + V+IWD GK + L + A V + Sbjct: 223 CDLSVEG--DSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGH--TARVGALA 278 Query: 258 TNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTV 317 N + G + IL D R Q + H + LK+ D S D + Sbjct: 279 WNAEQLSSGSRDRMILQRDIRTPPLQSE-RRLQGHRQEVCGLKWSTDHQLLASGGNDNKL 337 Query: 318 RIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCA---QSMDNRIYSFSLKPKYKRHPK 374 +W + P++Q ++ ++ + P Q+ A + D I ++ Sbjct: 338 LVWNHSSLSPVQQYTE-HLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCI 396 Query: 375 KIFKGHSSAGYGISLAFSGDGRYICS--GDSKSRLFTWDWNTSRLLNNIKIPGNKP-ITQ 431 +LA+S + S G S++++ W + + L K+ G+ + Sbjct: 397 DT------GSQVCNLAWSKHANELVSTHGYSQNQILVWKYPS--LTQVAKLTGHSYRVLY 448 Query: 432 VDWHPQETSKVICSGAAGKIYVCD 455 + P ++ + + Sbjct: 449 LAMSPD-GEAIVTGAGDETLRFWN 471 Score = 102 bits (254), Expect = 3e-22, Method: Composition-based stats. Identities = 34/250 (13%), Positives = 83/250 (33%), Gaps = 14/250 (5%) Query: 133 NDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF 192 N V V + + K + GH AL + + + SG D I D Sbjct: 242 NLVAVGTHKGFVQIWDAAAGKKLSMLEGHTARVGALAWNAEQ---LSSGSRDRMILQRDI 298 Query: 193 YHDY-ECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPA 251 + R QGH + + L+++ D Q S D + +W+ + + + Sbjct: 299 RTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAV 358 Query: 252 DVESRPTNPHEFIVGLS---NSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKF 308 + + H + + I ++ + + T S + L + ++ Sbjct: 359 KAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDT----GSQVCNLAWSKHANEL 414 Query: 309 IS--SSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLK 366 +S + +W+ + ++ + + +L + P + D + +++ Sbjct: 415 VSTHGYSQNQILVWKYPSLTQVAKL-TGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVF 473 Query: 367 PKYKRHPKKI 376 K + + + Sbjct: 474 SKTRSTKESV 483 >5K0Y-T nrPDB Length = 329 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 52/313 (16%), Positives = 100/313 (31%), Gaps = 68/313 (21%) Query: 158 YPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTED 217 GH T +K+ + G L+ + D + +W + + E L + GH + + D Sbjct: 6 LQGHERSITQIKYN-REGDLLFTVAKDPIVNVW-YSVNGERLGTYMGHTGAVWCVDADWD 63 Query: 218 CQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVES---------------------- 255 + L+ S D S ++WD ETGK L NS Sbjct: 64 TKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVS 123 Query: 256 ------------------RPTNPHE------------FIVGLSNSKILHYDDRVSENQGL 285 P N + I G + ++ Y + E + Sbjct: 124 FFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGE---V 180 Query: 286 VQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVH 345 + H I ++ + + F+++S+D T +++++ K + L Sbjct: 181 LVNVKEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFRTEPPRELAAL--S 238 Query: 346 PSQNYFCAQ---------SMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGR 396 P+ + + RI F + + ++ + G S+AF DG+ Sbjct: 239 PNYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGK 298 Query: 397 YICSGDSKSRLFT 409 SG + Sbjct: 299 SYSSGGEDGYVRI 311 >6ELZ-p nrPDB Length = 460 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 59/336 (17%), Positives = 116/336 (34%), Gaps = 48/336 (14%) Query: 150 LPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD-------------- 195 L V + Y GH A+K++ T ++S GND T+++W +D Sbjct: 132 LSGNVQKQYSGHSGPIRAVKYISNTR--LVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDD 189 Query: 196 --------YECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLN 247 + L +GH P+ ++ + D LS+S+D S+ W + ++ Sbjct: 190 DDEVNIEDGKTLAILEGHKAPVVSIDVS-DNSRILSASYDNSIGFW--------STIYKE 240 Query: 248 STPADVESRPTNPHEFIVGLSNSKILH-YDDRVSENQGLVQTYDHHLSSILALKY-FPDG 305 T D NP+ I + + D + + + H + + + + D Sbjct: 241 MTVVDPLEDINNPNNKISTAARKRRKLTMKDGTIRRRAPLSLLESHTAPVEQVIFDSTDN 300 Query: 306 SKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSL 365 + S S+D T++ W+ I T +S+ + + N S I Sbjct: 301 TVGYSVSQDHTIKTWDLVTARCIDT--RTTSYSLLSIAQLSTLNLLACGSSARHITLHDP 358 Query: 366 KPKYKRH-PKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIP 424 + ++ GH + + + +CSG + WD ++ + I Sbjct: 359 RVGASSKVTQQQLIGHKNFVSSLDTCP-ENEYILCSGSHDGTVKVWDVRSTSPMYTITRE 417 Query: 425 GNK-------PITQVDWHPQETSKVICSGAAGKIYV 453 + V W + +I +G KI + Sbjct: 418 DKSVQKGVNDKVFAVKWAEKVG--IISAGQDKKIQI 451 Score = 52.5 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 20/147 (13%), Positives = 38/147 (25%), Gaps = 26/147 (17%) Query: 291 HHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNY 350 + + +L IS S D VR W+ NV + + + + Sbjct: 101 SNEDWVSSLDVGDGSKHIISGSYDGIVRTWDLSGNVQKQY--SGHSGPIRAVKYISNTR- 157 Query: 351 FCAQSMDNRIYSFSLKPKY--------------------KRHPKKIFKGHSSAGYGISLA 390 + D + + K I +GH + I ++ Sbjct: 158 LVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDVS 217 Query: 391 FSGDGRYICSGDSKSRLFTWDWNTSRL 417 D I S + + W + Sbjct: 218 ---DNSRILSASYDNSIGFWSTIYKEM 241 >4BZK-B nrPDB Length = 297 Score = 119 bits (297), Expect = 4e-27, Method: Composition-based stats. Identities = 47/277 (16%), Positives = 96/277 (34%), Gaps = 28/277 (10%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD-YECLRDFQGHNKPIKALRFTED- 217 H E L G + + +D TIKI++ + ++ + GH P+ + + Sbjct: 7 AHNELIHD-AVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPK 65 Query: 218 -CQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHE----FIVGLSNSKI 272 S S+D V IW E G+ A V S PHE +V S+ K+ Sbjct: 66 FGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125 Query: 273 LHYDDRVSENQGLVQTYDHHLSSILALKYFP-------------DGSKFISSSEDKTVRI 319 + + + + D H + + + P + KF++ D V+I Sbjct: 126 SVVEFKENGTTSPI-IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 184 Query: 320 WENQIN---VPIKQISDTAQHSMPFLNVHPS---QNYFCAQSMDNRIYSFSLKPKYKRHP 373 W+ + ++ + + + P+ ++Y + S D ++ + Sbjct: 185 WKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWK 244 Query: 374 KKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTW 410 K + K ++S G + +++ W Sbjct: 245 KTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 109 bits (272), Expect = 2e-24, Method: Composition-based stats. Identities = 37/238 (15%), Positives = 85/238 (35%), Gaps = 27/238 (11%) Query: 153 KVIRNYPGHPEGTTALKF-LPKTGHLILSGGNDHTIKIWDFYHD-YECLRDFQGHNKPIK 210 K+I GH + + PK G ++ S D + IW + + + H+ + Sbjct: 44 KLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVN 103 Query: 211 ALRFTED--CQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNP-------- 260 ++++ L +S D V + + + + + +++ V S P Sbjct: 104 SVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGE 163 Query: 261 -------HEFIVGLSNSKILHYDDRVSENQGLV-QTYDHHLSSILALKYFPDG---SKFI 309 +F+ G +++ + + ++ T + H + + + P S Sbjct: 164 HNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLA 223 Query: 310 SSSEDKTVRIW--ENQINVPIKQISDTAQ--HSMPFLNVHPSQNYFCAQSMDNRIYSF 363 S S+D+T IW +N+ K + + + + S N DN++ + Sbjct: 224 SVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 90.3 bits (222), Expect = 2e-18, Method: Composition-based stats. Identities = 42/277 (15%), Positives = 89/277 (32%), Gaps = 28/277 (10%) Query: 204 GHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTE--TGKVKTRLHLNSTPA-DVESRPTNP 260 HN+ I + + S D+++KI++ E T K+ L + P V+ Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 261 HEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPD--GSKFISSSEDKTVR 318 + S + + + + H +S+ ++++ P G + +S D V Sbjct: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 Query: 319 IWENQINVPIK-QISDTAQHSMPFLNVHPS-------------QNYFCAQSMDNRIYSFS 364 + E + N I D + + P+ F DN + + Sbjct: 127 VVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKIWK 186 Query: 365 LKPKYKRHPKK-IFKGHSSAGYGISLAFSGD---GRYICSGDSKSRLFTWDWNTSRLLNN 420 + + + +GHS + +A+S Y+ S W + + Sbjct: 187 YNSDAQTYVLESTLEGHSD--WVRDVAWSPTVLLRSYLASVSQDRTCIIWTQDNEQGPWK 244 Query: 421 IKIPGNKPITQVDWHPQ---ETSKVICSGAAGKIYVC 454 + + V W + + SG K+ + Sbjct: 245 KTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 >5OQL-J nrPDB Length = 912 Score = 118 bits (296), Expect = 4e-27, Method: Composition-based stats. Identities = 52/281 (18%), Positives = 98/281 (34%), Gaps = 49/281 (17%) Query: 127 GYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALK------------FLPKT 174 G+ D R R+ + GH E A+ F Sbjct: 445 GHWIASGSKDNTARLWRVDPAN-NSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPL 503 Query: 175 GH---LILSGGNDHTIKIWD----FYHDYECLRDFQ--GHNKPIKALRFTEDCQSFLSSS 225 H ++SG D ++ D + + H+K I AL + + + F S+S Sbjct: 504 DHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASAS 563 Query: 226 FDRSVKIWDTETGKVKTRLHLNS-TPADVESRPTNPHEF-------------IVGLSNSK 271 D++VKIWD E +V+ L + V P N + G + Sbjct: 564 QDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKT 623 Query: 272 ILHYDDRVSENQGLVQTYDHHLSSILALKY---FPDGS------KFISSSEDKTVRIWEN 322 I ++ + ++T++ H ++L + + D S +F S+ D V++W+ Sbjct: 624 IKLWNL---SDYTCIRTFEGHSHNVLKVVWLHISRDDSITKTKVQFASAGADTLVKVWDA 680 Query: 323 QINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSF 363 + D + + L VH N + D+++ + Sbjct: 681 NTGETECTL-DNHEDRLWTLAVHSKTNILASAGSDSKVTFW 720 Score = 112 bits (280), Expect = 3e-25, Method: Composition-based stats. Identities = 36/185 (19%), Positives = 61/185 (32%), Gaps = 28/185 (15%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQ 219 H + AL P G L S D T+KIWD E +GH + + +RF Sbjct: 542 AHDKDINALDISP-NGKLFASASQDKTVKIWDV-EKLEVQGILRGHKRGVWTVRFAPLNT 599 Query: 220 --------------SFLSSSFDRSVKIWDTETGKVKTRLHLNST-PADVESRPTNPH--- 261 L+ S D+++K+W+ +S V + Sbjct: 600 PVIQGEQGSVSGRGVVLTGSGDKTIKLWNLSDYTCIRTFEGHSHNVLKVVWLHISRDDSI 659 Query: 262 -----EFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKT 316 +F +++ + +D E + T D+H + L + S+ D Sbjct: 660 TKTKVQFASAGADTLVKVWDANTGETEC---TLDNHEDRLWTLAVHSKTNILASAGSDSK 716 Query: 317 VRIWE 321 V W Sbjct: 717 VTFWR 721 Score = 107 bits (267), Expect = 1e-23, Method: Composition-based stats. Identities = 38/171 (22%), Positives = 68/171 (39%), Gaps = 25/171 (14%) Query: 131 PPNDVDVDLREERISFRCYLPKKVIRN--YPGHPEGTTALKFLPKTGHLI---------- 178 PN + + + + +K+ GH G ++F P +I Sbjct: 553 SPNGKLFASASQDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGR 612 Query: 179 ---LSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRF---TEDCQ------SFLSSSF 226 L+G D TIK+W+ DY C+R F+GH+ + + + + D F S+ Sbjct: 613 GVVLTGSGDKTIKLWNL-SDYTCIRTFEGHSHNVLKVVWLHISRDDSITKTKVQFASAGA 671 Query: 227 DRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDD 277 D VK+WD TG+ + L + + + + S+SK+ + D Sbjct: 672 DTLVKVWDANTGETECTLDNHEDRLWTLAVHSKTNILASAGSDSKVTFWRD 722 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 59/409 (14%), Positives = 113/409 (27%), Gaps = 79/409 (19%) Query: 119 SEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLI 178 + G LR + + KK G E + LP+ LI Sbjct: 278 ESVGFLNEGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEG--EAILSAVSLPER-SLI 334 Query: 179 LSGGNDHTIKIWDFYHD-----------YECLRDFQGHNKPIKALRF-TEDCQSFLSSSF 226 L D T+ ++ E R G + I L + D ++ Sbjct: 335 LCAQADFTLVLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMAIATN 394 Query: 227 DRSVKIWDTET-----------------GKVKTRLHLNSTPADVESRPTNPHEFIVGLSN 269 ++I + G L + + H G + Sbjct: 395 SEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKD 454 Query: 270 SKILHYD-DRVSENQGLVQTYDHHLSSILALKYF----PDGS------------KFISSS 312 + + D + + + HL S+ A+ P S IS S Sbjct: 455 NTARLWRVDPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLDHPPAFLISGS 514 Query: 313 EDKTV------RIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLK 366 +D+ V R + + + L++ P+ F + S D + + ++ Sbjct: 515 QDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPNGKLFASASQDKTVKIWDVE 574 Query: 367 PKYKRHPKKIFKGHSSAGYGISLA-------------FSGDGRYICSGDSKSRLFTWDWN 413 K + I +GH + + A SG G + +G + W+ + Sbjct: 575 ---KLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVL-TGSGDKTIKLWNLS 630 Query: 414 TSRLLNNIKIPGNKPITQVDWHPQETSKV-------ICSGAAGKIYVCD 455 + + + + V H + +GA + V D Sbjct: 631 DYTCIRTFEGHSHNVLKVVWLHISRDDSITKTKVQFASAGADTLVKVWD 679 Score = 102 bits (255), Expect = 3e-22, Method: Composition-based stats. Identities = 42/270 (15%), Positives = 86/270 (31%), Gaps = 34/270 (12%) Query: 173 KTGHLILSGGNDHTIKIWDFYHDY------ECLRDFQGHNKPIKALRFTEDCQSFLSSSF 226 + + G D I+I+D Y + R + H ++ + ++ + + LS S Sbjct: 193 ASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSR 252 Query: 227 DRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLV 286 D+++ +W G + L + ++ + +D Sbjct: 253 DKTMTLWLWRDGIWQGTPMLRHELLESVGFLNEGKWMYSAGTSGVLRIWDTTTHHEITKK 312 Query: 287 QTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQIN------------VPIKQISDT 334 Q +IL+ P+ S + + D T+ ++ P ++IS T Sbjct: 313 QDAKSEGEAILSAVSLPERSLILCAQADFTLVLYRVPSPADVVSSSEGILLEPFRRISGT 372 Query: 335 AQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYK--------------RHPKKIFKGH 380 + + P Q+ + I S+K H + KGH Sbjct: 373 HDEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGH 432 Query: 381 SSAGYGISLAFSGDGRYICSGDSKSRLFTW 410 + + +S G +I SG + W Sbjct: 433 EDIVMSLDVDWS--GHWIASGSKDNTARLW 460 Score = 93.3 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 36/275 (13%), Positives = 88/275 (32%), Gaps = 38/275 (13%) Query: 217 DCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYD 276 + L+S+ + + + TGK + + P + + IV + + Y Sbjct: 30 NGARILASTLGENAILTELNTGKRLAEIQGDGEPISTLTITPSGSHLIVCSRSLTMRIYS 89 Query: 277 DRVSEN-----QGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQI 331 +S + LV+T H + ++ L + + + D ++IW+ + Sbjct: 90 LAISPDYDSVEPTLVRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIGGYVTHTV 149 Query: 332 SDTA---------QHSMPFLNVHPSQN--------------------YFCAQSMDNRIYS 362 S + + ++ + ++ + D RI Sbjct: 150 SGPSVLVSALHFFEIAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRI 209 Query: 363 FSL--KPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNN 420 F L + + K + +A+S + + SG + W W + Sbjct: 210 FDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDG-IWQG 268 Query: 421 IKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 + ++ + V + E + +G +G + + D Sbjct: 269 TPMLRHELLESVGF-LNEGKWMYSAGTSGVLRIWD 302 Score = 92.6 bits (228), Expect = 3e-19, Method: Composition-based stats. Identities = 43/310 (13%), Positives = 90/310 (29%), Gaps = 45/310 (14%) Query: 146 FRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYE-------C 198 K + G E + L P HLI+ T++I+ + Sbjct: 45 LTELNTGKRLAEIQGDGEPISTLTITPSGSHLIV-CSRSLTMRIYSLAISPDYDSVEPTL 103 Query: 199 LRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETG----------KVKTRLHLNS 248 +R + H P+ L + + D ++KIWD G + + LH Sbjct: 104 VRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHFFE 163 Query: 249 TPADVESRPTNPHE--------------------FIVGLSNSKILHYDDRVSENQGLVQT 288 ES+ +N G + +I +D + Sbjct: 164 IAVTAESQSSNKKPKKGSRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYAD 223 Query: 289 Y----DHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNV 344 + H S++ + Y P+ +S S DKT+ +W + + + + + Sbjct: 224 PKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDGI-WQGTPMLRHELLESVGF 282 Query: 345 HPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSK 404 + + + + ++ K+ S +S + I + Sbjct: 283 LNEGKWMYSAGTSGVLRIWDTTTHHEITKKQ--DAKSEGEAILSAVSLPERSLILCAQAD 340 Query: 405 SRLFTWDWNT 414 L + + Sbjct: 341 FTLVLYRVPS 350 >4XYI-A nrPDB Length = 430 Score = 113 bits (282), Expect = 2e-25, Method: Composition-based stats. Identities = 43/236 (18%), Positives = 83/236 (35%), Gaps = 22/236 (9%) Query: 59 RRKTRKGDGPWGSWSSSDDETSQASETQKEDQDIFVHALA-EDNLDSEQIEVEEVSHFYG 117 R T +G G ++ + +T DI +L+ E ++D + V Sbjct: 179 RHHTSEGFGLGWNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVV 238 Query: 118 KSEKDYQGRGYLYPP--NDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTG 175 + + L +D + + + R+ + V H + + F P Sbjct: 239 NDLQFHLQHEALLTSVSDDCTLQIHDTRLPSSSSASQCV----KAHEQPVNGVAFNPFND 294 Query: 176 HLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTE-DCQSFLSSSFDRSVKIWD 234 +L+ + DHT+ +WD + L +GH + ++++ D ++SS DR V +WD Sbjct: 295 YLLATASADHTVALWDLRRLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWD 354 Query: 235 T------------ETGKVKTRLHLNSTPADVESRPTNPH--EFIVGLSNSKILHYD 276 E G + V NP+ + L++ IL Sbjct: 355 LSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIW 410 Score = 110 bits (274), Expect = 1e-24, Method: Composition-based stats. Identities = 37/281 (13%), Positives = 94/281 (33%), Gaps = 31/281 (11%) Query: 161 HPEGTTALKFLPKTGHLILSGGNDHTIKIWDF--YHDYECLRD-----FQGHNKPIKALR 213 H +F+P+ +I + G + I+D Y + ++ + H L Sbjct: 130 HEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGLG 189 Query: 214 FTE-DCQSFLSSSFDRSVKIWDTETGKV----------KTRLHLNSTPADVESRPTNPHE 262 + + + + D S+ +WD + + + H ++ + Sbjct: 190 WNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEA 249 Query: 263 FIVGLSNS-KILHYDDRVSENQGLVQTYDHHLSSILALKYFP-DGSKFISSSEDKTVRIW 320 + +S+ + +D R+ + Q H + + + P + ++S D TV +W Sbjct: 250 LLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALW 309 Query: 321 ENQINVPIKQISDTAQHSMPFLNVHP-SQNYFCAQSMDNRIYSFSL---------KPKYK 370 + + + + + + P + S D R+ + L + Sbjct: 310 DLRRLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSED 369 Query: 371 RHPKKIFKGHSSAGYGISLAFSGDGRY-ICSGDSKSRLFTW 410 P+ +F L+++ + ++ + S + L W Sbjct: 370 GAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIW 410 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 33/200 (16%), Positives = 76/200 (38%), Gaps = 17/200 (8%) Query: 138 DLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWD--FYHD 195 D++ + +S + + Y H L+F + L+ S +D T++I D Sbjct: 211 DIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHEALLTSVSDDCTLQIHDTRLPSS 270 Query: 196 YECLRDFQGHNKPIKALRFTEDCQSFL-SSSFDRSVKIWDTE--TGKVKTRLHLNSTPAD 252 + + H +P+ + F L ++S D +V +WD ++ T + Sbjct: 271 SSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLNQRLHTLEGHEDEVYN 330 Query: 253 VESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYD-----------HHLSSILALKY 301 V+ P + + ++ ++ +D + V+ + H + + L + Sbjct: 331 VQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGGHTNRVSDLSW 390 Query: 302 FPDGSK-FISSSEDKTVRIW 320 P+ S ++D ++IW Sbjct: 391 NPNNKWVLASLADDNILQIW 410 Score = 101 bits (250), Expect = 1e-21, Method: Composition-based stats. Identities = 38/286 (13%), Positives = 89/286 (31%), Gaps = 39/286 (13%) Query: 204 GHNKPIKALRFTEDC-QSFLSSSFDRSVKIWD---------TETGKVKTRLHLNSTPADV 253 H + RF + + + I+D +TG H S + Sbjct: 129 HHEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGL 188 Query: 254 ESRPTNPHEFIVGLSNSKILHYDDRVSE-------NQGLVQTYDHHLSSILALKYF-PDG 305 G ++ I +D + + V Y H + + L++ Sbjct: 189 GWNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFHLQHE 248 Query: 306 SKFISSSEDKTVRIWENQ--INVPIKQISDTAQHSMPFLNVHP-SQNYFCAQSMDNRIYS 362 + S S+D T++I + + + Q + + + +P + S D+ + Sbjct: 249 ALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVNGVAFNPFNDYLLATASADHTVAL 308 Query: 363 FSLKPKYKRHPKKIFKGHSSAGYGISLAFSG-DGRYICSGDSKSRLFTWDWNT------- 414 + L+ +R +GH Y ++ +S D + + + R+ WD + Sbjct: 309 WDLRRLNQR--LHTLEGHEDEVY--NVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTV 364 Query: 415 ------SRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVC 454 + L + ++ + W+P + + + Sbjct: 365 EDSEDGAPELMFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIW 410 Score = 80.6 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 39/234 (16%), Positives = 81/234 (34%), Gaps = 25/234 (10%) Query: 242 TRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQT-----YDHHLSSI 296 ++H P NP N +D + Q +VQT HH S Sbjct: 126 QKIHHEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEG 185 Query: 297 LALKYF--PDGSKFISSSEDKTVRIWENQIN-------VPIKQISDTAQHS--MPFLNVH 345 L + +G+ + +ED ++ +W+ + + + +S +H+ + L H Sbjct: 186 FGLGWNFIQEGT-LATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAVVNDLQFH 244 Query: 346 PSQN-YFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSG-DGRYICSGDS 403 + S D + + + K H +AF+ + + + + Sbjct: 245 LQHEALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQPVN--GVAFNPFNDYLLATASA 302 Query: 404 KSRLFTWDWNTSRLLNNIK-IPGNKP-ITQVDWHPQETSKVICSGAAGKIYVCD 455 + WD RL + + G++ + V W P + ++ S ++ V D Sbjct: 303 DHTVALWDLR--RLNQRLHTLEGHEDEVYNVQWSPHDEPILVTSSTDRRVCVWD 354 >5A31-R nrPDB Length = 386 Score = 112 bits (280), Expect = 3e-25, Method: Composition-based stats. Identities = 50/286 (17%), Positives = 94/286 (32%), Gaps = 54/286 (18%) Query: 83 SETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREE 142 S D+ AL + ++ + V +E +Y ++ + + V Sbjct: 96 SLIDWSSTDVLAVALGKSIFLTDNNTGDVV--HLCDTENEYTSLSWIGAGSHLAVGQANG 153 Query: 143 RISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTI--------------- 187 + + +K IR GH + L + H++ SG DH I Sbjct: 154 LVEIYDVMKRKCIRTLSGHIDRVACLSWNN---HVLTSGSRDHRILHRDVRMPDPFFETI 210 Query: 188 ---------KIWDFY------------------HDYECLRDFQGHNKPIKALRFTEDCQS 220 W+ + F H +KA+ ++ + Sbjct: 211 ESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRG 270 Query: 221 FLS---SSFDRSVKIWDTETGKVKTRLHLNSTPAD-VESRPTNPHEFIVGLSNSKILHYD 276 L+ + DR +KIW+ T + + S + V S+ TN G S + +D Sbjct: 271 VLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWD 330 Query: 277 DRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWEN 322 + + H +L L DG+ +S + D+T+R W+ Sbjct: 331 ---CNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKL 373 Score = 108 bits (270), Expect = 5e-24, Method: Composition-based stats. Identities = 48/268 (17%), Positives = 99/268 (36%), Gaps = 19/268 (7%) Query: 162 PEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSF 221 T+L ++ G + G + ++I+D +C+R GH + L + Sbjct: 131 ENEYTSLSWI-GAGSHLAVGQANGLVEIYDVMK-RKCIRTLSGHIDRVACLSWNNH--VL 186 Query: 222 LSSSFDRSVKIWDTETGKVK-TRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVS 280 S S D + D + ++ ++ G +++ + Y Sbjct: 187 TSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVY---EG 243 Query: 281 ENQGLVQTYDHHLSSILALKYFPDGSKFISSS---EDKTVRIWENQINVPIKQISDTAQH 337 ++ + T+D H +++ A+ + P +++ D+ ++IW ++ + I +Q Sbjct: 244 TSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQ- 302 Query: 338 SMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRY 397 + + + N S Y+ +L P I KGHS ++L S DG Sbjct: 303 -ICNMVWSKNTNELVT-SHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTL--SNDGTT 358 Query: 398 ICSGDSKSRLFTW---DWNTSRLLNNIK 422 + SG L W D + L I+ Sbjct: 359 VVSGAGDETLRYWKLFDVSVLNLFTRIR 386 Score = 67.5 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 22/180 (12%), Positives = 58/180 (32%), Gaps = 10/180 (5%) Query: 278 RVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQH 337 N G V + +L + GS + V I++ I+ +S H Sbjct: 116 LTDNNTGDVVHLCDTENEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLS---GH 172 Query: 338 SMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRY 397 + + + + S D+RI ++ + + H+ L ++ Sbjct: 173 IDRVACLSWNNHVLTSGSRDHRILHRDVRMPDPFF--ETIESHTQEV--CGLKWNVADNK 228 Query: 398 ICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGA--AGKIYVCD 455 + SG + + + ++ + + + + W P + + G ++ + + Sbjct: 229 LASGGNDNVVHVYEGTSKSPILTFDEH-KAAVKAMAWSPHKRGVLATGGGTADRRLKIWN 287 >2AQ5-A nrPDB Length = 402 Score = 111 bits (277), Expect = 7e-25, Method: Composition-based stats. Identities = 35/225 (15%), Positives = 78/225 (34%), Gaps = 19/225 (8%) Query: 160 GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDY------ECLRDFQGHNKPIKALR 213 GH + + P ++I SG D T+ +W+ E + +GH K + + Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVA 138 Query: 214 FTED-CQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPT--NPHEFIVGLSNS 270 + LS+ D + +WD TG L + P + S + + Sbjct: 139 WHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCRDK 198 Query: 271 KILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISS---SEDKTVRIWENQI--- 324 ++ + R + A+ + +G + ++ V +W+ + Sbjct: 199 RVRVIEPRKGTVVAEKDRPHEGTRPVHAV-FVSEGKILTTGFSRMSERQVALWDTKHLEE 257 Query: 325 NVPIKQISDTAQHSMPFLNVHPSQNYF-CAQSMDNRIYSFSLKPK 368 + ++++ ++ +PF P N D+ I F + + Sbjct: 258 PLSLQELDTSSGVLLPF--FDPDTNIVYLCGKGDSSIRYFEITSE 300 Score = 101 bits (251), Expect = 7e-22, Method: Composition-based stats. Identities = 39/239 (16%), Positives = 84/239 (35%), Gaps = 21/239 (8%) Query: 131 PPNDVDVDLREERISFRCYL---------PKKVIRNYPGHPEGTTALKFLPKTGHLILSG 181 P ND + E + + ++ + GH + + + P +++LS Sbjct: 91 PHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVAWHPTAQNVLLSA 150 Query: 182 GNDHTIKIWDFYHDYECLRDF--QGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGK 239 G D+ I +WD L H I ++ ++ D +S D+ V++ + G Sbjct: 151 GCDNVILVWDVGTGAAVL-TLGPDVHPDTIYSVDWSRDGALICTSCRDKRVRVIEPRKGT 209 Query: 240 VKTRLHL-NSTPADVESRPTNPHEFIVGL----SNSKILHYDDRVSENQGLVQTYDHHLS 294 V + V + + + + S ++ +D + E +Q D S Sbjct: 210 VVAEKDRPHEGTRPVHAVFVSEGKILTTGFSRMSERQVALWDTKHLEEPLSLQELDT-SS 268 Query: 295 SILALKYFPDGSKFISSSE-DKTVRIWENQINVPIKQISD--TAQHSMPFLNVHPSQNY 350 +L + PD + + D ++R +E P +++ S + P + Sbjct: 269 GVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEAPFLHYLSMFSSKESQRGMGYMPKRGL 327 Score = 95.7 bits (236), Expect = 4e-20, Method: Composition-based stats. Identities = 34/226 (15%), Positives = 75/226 (33%), Gaps = 18/226 (7%) Query: 204 GHNKPIKALRFTEDC-QSFLSSSFDRSVKIWDTETG-------KVKTRLHLNSTPADVES 255 GH P+ + + S S D +V +W+ G + L ++ + + Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVA 138 Query: 256 RPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDK 315 ++ ++ D + L D H +I ++ + DG+ +S DK Sbjct: 139 WHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCRDK 198 Query: 316 TVRIWENQIN--VPIKQISDTAQHSMPFLNVHPSQNYFCAQ---SMDNRIYSFSLKPKYK 370 VR+ E + V K + + V + ++ + K+ Sbjct: 199 RVRVIEPRKGTVVAEKDRPHEGTRPVHAVFVS-EGKILTTGFSRMSERQVALWD--TKHL 255 Query: 371 RHPKKIFKGHSSAGYGISLAFSGDGRYIC-SGDSKSRLFTWDWNTS 415 P + + +S+G + F D + G S + ++ + Sbjct: 256 EEPLSLQELDTSSGVLLPF-FDPDTNIVYLCGKGDSSIRYFEITSE 300 Score = 88.7 bits (218), Expect = 5e-18, Method: Composition-based stats. Identities = 44/256 (17%), Positives = 83/256 (32%), Gaps = 24/256 (9%) Query: 218 CQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIV---GLSNSKILH 274 + + SS R V + + + ++ T D NP + L Sbjct: 2 SRQVVRSSKFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFMALICEASGGGAFLV 61 Query: 275 YDD-RVSENQGLVQTYDHHLSSILALKYFPDGS-KFISSSEDKTVRIWENQINVPIKQI- 331 + V H + +L + + P S SED TV +WE + + Sbjct: 62 LPLGKTGRVDKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLR 121 Query: 332 -----SDTAQHSMPFLNVHPS-QNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGY 385 + + + HP+ QN + DN I + + H Y Sbjct: 122 EPVITLEGHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGP-DVHPDTIY 180 Query: 386 GISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIP--GNKPITQVDWHPQETSKVI 443 S+ +S DG IC+ R+ + ++ P G +P+ V K++ Sbjct: 181 --SVDWSRDGALICTSCRDKRVRVIEPRKGTVVAEKDRPHEGTRPVHAVFVSE---GKIL 235 Query: 444 CSG----AAGKIYVCD 455 +G + ++ + D Sbjct: 236 TTGFSRMSERQVALWD 251 >5CXC-A nrPDB Length = 510 Score = 111 bits (276), Expect = 9e-25, Method: Composition-based stats. Identities = 58/351 (16%), Positives = 110/351 (31%), Gaps = 72/351 (20%) Query: 130 YPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGH------------- 176 N + ++ R +P ++ H + +A+ L T Sbjct: 95 LTSNGLSLETTLTLQYVRSLIPPVYEASFE-HDDWVSAVDVLSATSPAGRWSSAANSSAA 153 Query: 177 ------LILSGGNDHTIKIWDFYHDY---ECLRDFQGHNKPIKALRFTEDCQSFLSSSFD 227 +LS D ++IW+ GH IKA +F + S+ D Sbjct: 154 VQPGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSDR-LASAGMD 212 Query: 228 RSVKIW-----DTETGKVKTRLHLNSTPADVESRPTNPHE--FIVGLSNSKILHYDDR-- 278 R+V++W D TG++K L L V+ + H + ++ I + Sbjct: 213 RTVRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVDGHSKHILTASADGAIGFWSASKA 272 Query: 279 -------------------------VSENQGLVQTYDHHLSSILALKYFPDGSKFI-SSS 312 + +G + + H + A + P S+S Sbjct: 273 SAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSAS 332 Query: 313 EDKTVRIWENQINVPIKQISDTAQHSMPFLNVHP------SQNYFCAQSMDNRIYSFSLK 366 +D TVR + + ++ T P L++ + A + I + Sbjct: 333 QDHTVRTLDLTTGQVVSTLTLTH----PLLSLSALTRAGTTSPLLAAGTSARHITMVDPR 388 Query: 367 PKYKRHPKKIFKGHSSAGYGISLAFSGDGRY-ICSGDSKSRLFTWDWNTSR 416 +GH++ +SL+ S + Y + SG WD + R Sbjct: 389 ASSATTSVMTLRGHANKV--VSLSPSPENEYSLVSGSHDGTCRVWDLRSVR 437 Score = 82.9 bits (203), Expect = 3e-16, Method: Composition-based stats. Identities = 66/391 (16%), Positives = 117/391 (29%), Gaps = 66/391 (16%) Query: 61 KTRKGDGPWGSWSSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSE 120 P G WSS+ + ++ Q+ L S + S +G Sbjct: 133 DVLSATSPAGRWSSAANSSAAVQPGQERVLSASYDGLLRIWNASGSVIATSPSGSHGGHT 192 Query: 121 KDYQGRGYL----YPPNDVDVDLREERISFRCYLPKKVIRNYP--GHPEGTTALKFLPKT 174 + +L +D +R + + + ++ GH ++ +L Sbjct: 193 ASIKAAKFLTSDRLASAGMDRTVRVWKYTESDHFTGELKPTLELYGHTG---SVDWLDVD 249 Query: 175 GH--LILSGGNDHTIKIWDFYH-----------------------------DYECLRDFQ 203 GH IL+ D I W L + Sbjct: 250 GHSKHILTASADGAIGFWSASKASAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWS 309 Query: 204 GHNKPIKALRFTEDCQSFL-SSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRP---TN 259 H P A F ++ S+S D +V+ D TG+V + L L + + T Sbjct: 310 IHTAPATAAIFDPRDRTVAYSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTT 369 Query: 260 PHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSK-FISSSEDKTVR 318 G S I D R S V T H + +++L P+ +S S D T R Sbjct: 370 SPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCR 429 Query: 319 IWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFK 378 +W+ + P + + + V +++ K K+ Sbjct: 430 VWDLRSVRPATKEEGSLGGVSEPVYVIERESW-----------------ASKGKKKRPVA 472 Query: 379 GHSSAGYGISLAFSGDGRYICSGDSKSRLFT 409 G + S+ + D I SG ++ Sbjct: 473 GDGCKVF--SVVW--DKLGIFSGGEDKKVQV 499 Score = 51.7 bits (122), Expect = 7e-07, Method: Composition-based stats. Identities = 36/219 (16%), Positives = 62/219 (28%), Gaps = 35/219 (15%) Query: 34 DTSYEPSSNNIHKRKSHFTKSELKRRRKTRKGDGPWGSWSSSDDETS-------QASETQ 86 D S P ++ +RK+ + S +R GP G WS + + Sbjct: 278 DASLLPGAHVSKRRKATSSVSTAQR--------GPLGLWSIHTAPATAAIFDPRDRTVAY 329 Query: 87 KEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLRE-ERIS 145 QD V L S G P R + Sbjct: 330 SASQDHTVRTLDLTTGQVVSTLTL---THPLLSLSALTRAGTTSPLLAAGTSARHITMVD 386 Query: 146 FRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLR---DF 202 R + GH +L P+ + ++SG +D T ++WD + Sbjct: 387 PRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKEEGSL 446 Query: 203 QGHNKPIKAL---RFTE----------DCQSFLSSSFDR 228 G ++P+ + + D S +D+ Sbjct: 447 GGVSEPVYVIERESWASKGKKKRPVAGDGCKVFSVVWDK 485 >4BH6-A nrPDB Length = 308 Score = 110 bits (275), Expect = 1e-24, Method: Composition-based stats. Identities = 50/286 (17%), Positives = 94/286 (32%), Gaps = 54/286 (18%) Query: 83 SETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREE 142 S D+ AL + ++ + V +E +Y ++ + + V Sbjct: 27 SLIDWSSTDVLAVALGKSIFLTDNNTGDVV--HLCDTENEYTSLSWIGAGSHLAVGQANG 84 Query: 143 RISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTI--------------- 187 + + +K IR GH + L + H++ SG DH I Sbjct: 85 LVEIYDVMKRKCIRTLSGHIDRVACLSWNN---HVLTSGSRDHRILHRDVRMPDPFFETI 141 Query: 188 ---------KIWDFY------------------HDYECLRDFQGHNKPIKALRFTEDCQS 220 W+ + F H +KA+ ++ + Sbjct: 142 ESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRG 201 Query: 221 FLS---SSFDRSVKIWDTETGKVKTRLHLNSTPAD-VESRPTNPHEFIVGLSNSKILHYD 276 L+ + DR +KIW+ T + + S + V S+ TN G S + +D Sbjct: 202 VLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWD 261 Query: 277 DRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWEN 322 + + H +L L DG+ +S + D+T+R W+ Sbjct: 262 ---CNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKL 304 Score = 105 bits (262), Expect = 3e-23, Method: Composition-based stats. Identities = 45/253 (17%), Positives = 94/253 (37%), Gaps = 16/253 (6%) Query: 162 PEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSF 221 T+L ++ G + G + ++I+D +C+R GH + L + Sbjct: 62 ENEYTSLSWI-GAGSHLAVGQANGLVEIYDVMK-RKCIRTLSGHIDRVACLSWNNH--VL 117 Query: 222 LSSSFDRSVKIWDTETGKVK-TRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVS 280 S S D + D + ++ ++ G +++ + Y Sbjct: 118 TSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVY---EG 174 Query: 281 ENQGLVQTYDHHLSSILALKYFPDGSKFISSS---EDKTVRIWENQINVPIKQISDTAQH 337 ++ + T+D H +++ A+ + P +++ D+ ++IW ++ + I +Q Sbjct: 175 TSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQ- 233 Query: 338 SMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRY 397 + + + N S Y+ +L P I KGHS ++L S DG Sbjct: 234 -ICNMVWSKNTNELVT-SHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTL--SNDGTT 289 Query: 398 ICSGDSKSRLFTW 410 + SG L W Sbjct: 290 VVSGAGDETLRYW 302 Score = 66.4 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 22/180 (12%), Positives = 58/180 (32%), Gaps = 10/180 (5%) Query: 278 RVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQH 337 N G V + +L + GS + V I++ I+ +S H Sbjct: 47 LTDNNTGDVVHLCDTENEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLS---GH 103 Query: 338 SMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRY 397 + + + + S D+RI ++ + + H+ L ++ Sbjct: 104 IDRVACLSWNNHVLTSGSRDHRILHRDVRMPDPFF--ETIESHTQEV--CGLKWNVADNK 159 Query: 398 ICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGA--AGKIYVCD 455 + SG + + + ++ + + + + W P + + G ++ + + Sbjct: 160 LASGGNDNVVHVYEGTSKSPILTFDEH-KAAVKAMAWSPHKRGVLATGGGTADRRLKIWN 218 >5WYJ-BE nrPDB Length = 939 Score = 110 bits (274), Expect = 1e-24, Method: Composition-based stats. Identities = 59/333 (17%), Positives = 110/333 (33%), Gaps = 44/333 (13%) Query: 150 LPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFY-----HDYECLRDFQG 204 P + +R+ GH + + + F H +LS D + +W F E + Sbjct: 338 QPPRYLRSRGGHSQPPSYIAFADSQSHFMLSASKDRS--LWSFSLRKDAQSQEMSQRL-- 393 Query: 205 HNK----------------PIKALRFTE----DCQSFLSSSFD-RSVKIWDTETGKV--K 241 H K I AL + ++ +++ D + + WD +V Sbjct: 394 HKKQDGGRVGGSTIKSKFPEIVALAIENARIGEWENIITAHKDEKFARTWDMRNKRVGRW 453 Query: 242 TRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKY 301 T + + + +G SN I Y+ + L + Y H ++ + Sbjct: 454 TFDTTDDGFVKSVAMSQCGNFGFIGSSNGSITIYNMQSG---ILRKKYKLHKRAVTGISL 510 Query: 302 FPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIY 361 K +S D V ++ + + ++ A + + H S + F D I Sbjct: 511 DGMNRKMVSCGLDGIVGFYDFNKSTLLGKLKLDA--PITAMVYHRSSDLFALALDDLSIV 568 Query: 362 SFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNI 421 + + GHS+ + FS +GR+I S S + TWD T ++ I Sbjct: 569 VIDA---VTQRVVRQLWGHSNR--ITAFDFSPEGRWIVSASLDSTIRTWDLPTGGCIDGI 623 Query: 422 KIPGNKPITQVDWHPQETSKVICSGAAGKIYVC 454 + T V + P I + Sbjct: 624 IVDN--VATNVKFSPNGDLLATTHVTGNGICIW 654 Score = 106 bits (263), Expect = 3e-23, Method: Composition-based stats. Identities = 54/360 (15%), Positives = 121/360 (33%), Gaps = 35/360 (9%) Query: 61 KTRKGDGPWGSWSSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSE 120 ++R G S+ + D S + +D+ ++ +L +D E + K + Sbjct: 344 RSRGGHSQPPSYIAFADSQSHFMLSASKDRSLWSFSLRKDAQSQEM-----SQRLHKKQD 398 Query: 121 KDYQGRGYLYPPNDVDVDLREERISFRCYLP-------KKVIRNY-------------PG 160 G + V L E + +K R + Sbjct: 399 GGRVGGSTIKSKFPEIVALAIENARIGEWENIITAHKDEKFARTWDMRNKRVGRWTFDTT 458 Query: 161 HPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQS 220 ++ + + G+ G ++ +I I++ + ++ H + + + + Sbjct: 459 DDGFVKSVA-MSQCGNFGFIGSSNGSITIYNMQSGI-LRKKYKLHKRAVTGISLDGMNRK 516 Query: 221 FLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVS 280 +S D V +D + +L L++ P + F + L + I+ D Sbjct: 517 MVSCGLDGIVGFYDFNKSTLLGKLKLDA-PITAMVYHRSSDLFALALDDLSIVVIDAVT- 574 Query: 281 ENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMP 340 Q +V+ H + I A + P+G +S+S D T+R W+ I I + Sbjct: 575 --QRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTGGCIDGI--IVDNVAT 630 Query: 341 FLNVHPSQNYFCAQ-SMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGI-SLAFSGDGRYI 398 + P+ + N I ++ + ++K + A + S + G+ + Sbjct: 631 NVKFSPNGDLLATTHVTGNGICIWTNRAQFKTVSTRTIDESEFARMALPSTSVRGNDSML 690 Score = 50.6 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 38/276 (13%), Positives = 90/276 (32%), Gaps = 34/276 (12%) Query: 175 GHLILSGGNDHTIKIWDFYHDYE----------CLRDFQGHNKPIKALRFTEDCQSFLSS 224 G + + +D++I I+ + + + QG I +L+ + L+ Sbjct: 125 GDYLCASTDDNSIFIYKKSDPQDKYPSEFYTKLTVTEIQG--GEIVSLQHLATYLNKLTV 182 Query: 225 SFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQG 284 +V +++ TGK+ + +G +++ ++ R + Sbjct: 183 VTKSNVLLFNVRTGKLVFTSNEFPDQITTAEPAPVLDIIALGTVTGEVIMFNMRKGKR-- 240 Query: 285 LVQTYDHHLSSILALKYFPDGSKFIS-SSEDKTVRIWENQINVPIKQISDTAQHS---MP 340 ++T S I +L + DGS +S + + ++ I + + + S + Sbjct: 241 -IRTIKIPQSRISSLSFRTDGSSHLSVGTSSGDLIFYDLDRRSRIHVLKNIHRESYGGVT 299 Query: 341 FLNVHPSQNYFCAQSMDNRIYSFSLKPKYKR----------HPKKIFKGHSSAGYGISLA 390 Q DN + + P + + GHS I+ A Sbjct: 300 QATFLNGQPIIVTSGGDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPSYIAFA 359 Query: 391 FSGDGRYICSGDSKSRLFTW----DWNTSRLLNNIK 422 S ++ S L+++ D + + + Sbjct: 360 DS-QSHFMLSASKDRSLWSFSLRKDAQSQEMSQRLH 394 >3BG0-A nrPDB Length = 316 Score = 109 bits (271), Expect = 3e-24, Method: Composition-based stats. Identities = 44/266 (16%), Positives = 89/266 (33%), Gaps = 31/266 (11%) Query: 175 GHLILSGGNDHTIKIWDFYHDYECL-RDFQGHNKPIKALRFTED--CQSFLSSSFDRSVK 231 G + + +D ++KI+D + + L D +GH P+ + + S S+DR V Sbjct: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 84 Query: 232 IWDTETGKVKTRLHLNSTPADVESRPTNPHE----FIVGLSNSKILHYDDRVSENQGLVQ 287 IW E G + + V S PH+ G S+ I + + Sbjct: 85 IWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 144 Query: 288 TYDHHLSSILALKY-----------FPDG------SKFISSSEDKTVRIWENQINVPIKQ 330 + H A+ + P G +F S D +++W+ + + K+ Sbjct: 145 INNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKE 204 Query: 331 ISDTAQHSMPFLNVHPSQNY------FCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAG 384 HS +V + + + S D R++ ++ H Sbjct: 205 EQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNT-WSPKLLHKFND 263 Query: 385 YGISLAFSGDGRYICSGDSKSRLFTW 410 +++S + +++ W Sbjct: 264 VVWHVSWSITANILAVSGGDNKVTLW 289 Score = 108 bits (270), Expect = 4e-24, Method: Composition-based stats. Identities = 35/241 (14%), Positives = 79/241 (32%), Gaps = 31/241 (12%) Query: 154 VIRNYPGHPEGTTALKF-LPKTGHLILSGGNDHTIKIWDFYHD-YECLRDFQGHNKPIKA 211 +I + GH + + P G+++ S D + IW + +E + GH+ + + Sbjct: 49 LIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNS 108 Query: 212 LRFTED--CQSFLSSSFDRSVKI--------WDTETGKVKTRLHLNS-------TPADVE 254 + + S D ++ + W+ + + N+ P + Sbjct: 109 VCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLI 168 Query: 255 SRPTNPHE-----FIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPD----G 305 P+ F G ++ I + + Q + H + + + P Sbjct: 169 DHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPT 228 Query: 306 SKFISSSEDKTVRIW---ENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYS 362 S S S+D V IW + N ++ + ++ + N DN++ Sbjct: 229 STIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTL 288 Query: 363 F 363 + Sbjct: 289 W 289 Score = 97.2 bits (240), Expect = 1e-20, Method: Composition-based stats. Identities = 50/281 (17%), Positives = 87/281 (30%), Gaps = 34/281 (12%) Query: 205 HNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETG--KVKTRLHLNSTPA-DVESRPTNPH 261 H I + + S DRSVKI+D G + L + P V Sbjct: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYG 71 Query: 262 EFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPD--GSKFISSSEDKTVRI 319 + S + + + + H SS+ ++ + P G S D + + Sbjct: 72 NILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISL 131 Query: 320 --------WENQINVPIKQISDTAQHSMPFLNV-----HPSQ------NYFCAQSMDNRI 360 WE + I A P + HPS F + DN I Sbjct: 132 LTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLI 191 Query: 361 YSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGD----GRYICSGDSKSRLFTW---DWN 413 + K + K+ K + + + +A++ I S R+F W D + Sbjct: 192 KLW--KEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDAS 249 Query: 414 TSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVC 454 ++ + N + V W + SG K+ + Sbjct: 250 SNTWSPKLLHKFNDVVWHVSWSITANI-LAVSGGDNKVTLW 289 Score = 53.7 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 15/88 (17%), Positives = 27/88 (30%), Gaps = 6/88 (6%) Query: 152 KKVIRNYPGHPEGTTALKFLPKTG---HLILSGGNDHTIKIW---DFYHDYECLRDFQGH 205 K + H + + + P G I S D + IW D + + Sbjct: 202 WKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKF 261 Query: 206 NKPIKALRFTEDCQSFLSSSFDRSVKIW 233 N + + ++ S D V +W Sbjct: 262 NDVVWHVSWSITANILAVSGGDNKVTLW 289 >5OQL-X nrPDB Length = 630 Score = 108 bits (269), Expect = 5e-24, Method: Composition-based stats. Identities = 48/298 (16%), Positives = 88/298 (29%), Gaps = 50/298 (16%) Query: 142 ERISFRCYLPKKV-IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLR 200 ERI F +K + Y GH + +K + G +++GG D + +++ D + ++ Sbjct: 225 ERICFAKADARKANDKTYQGHLKAPLVVK-ASQDGKFVVTGGADKRLVVYNAA-DLKPIK 282 Query: 201 DFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNP 260 F H + L F S S DR+VK+W + L + Sbjct: 283 AFTQHRDAVTGLAFRRGTNQLYSCSKDRTVKVWSLDELAYVETLFGHQDEILDIDALGQE 342 Query: 261 HEFIVGLSNSKILHYDDRVSENQ--------------------GLVQTYDHHLSSILALK 300 VG + ++ G+ H S+ + Sbjct: 343 RCVSVGARDRTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVA 402 Query: 301 YFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQ------------------------ 336 D F++ S++ + +W Q P+ I+ Sbjct: 403 MIDD-DMFVTGSDNGDLALWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAP 461 Query: 337 --HSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFS 392 + L P + + S D I + L ++ G S S S Sbjct: 462 QPRGITALRTLPYSDLIFSGSWDGCIRVWRLSEDKRKLEAVGILGVGSETCENSTNIS 519 Score = 66.8 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 54/399 (13%), Positives = 122/399 (30%), Gaps = 57/399 (14%) Query: 55 ELKRRRKTRKGDGPWGSWSSSDDETSQASETQKEDQDI--FVHALAEDNLDSEQIEVEEV 112 E RR + G G + Q+ + V L E D+E+I+ + + Sbjct: 74 EFIERRSSDAGSGDESEKEGETAAEKRLRLAQRYLEKTRKEVEQLDEYAFDAEEIDRDLL 133 Query: 113 SHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLP 172 + + + +G+ Y R++ K + + T++ P Sbjct: 134 AERLKEDVAEAKGKVY-------------RRLASELAFDKATYTQFRWNSGTVTSVAVCP 180 Query: 173 KTGHLILSGGNDHTIKIW---DFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRS 229 + D + W D + + KP + + F + Sbjct: 181 ---PYAYTTTKDGYLTKWKLQDLPKNQWPQTTKKKPKKPPAPPKKRPERICFAKA----- 232 Query: 230 VKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTY 289 D KT P V++ + + G ++ +++ Y+ + + ++ + Sbjct: 233 ----DARKANDKTYQGHLKAPLVVKA-SQDGKFVVTGGADKRLVVYN---AADLKPIKAF 284 Query: 290 DHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQN 349 H ++ L + ++ S S+D+TV++W ++ + H L++ Sbjct: 285 TQHRDAVTGLAFRRGTNQLYSCSKDRTVKVWSLDELAYVETLF---GHQDEILDIDALGQ 341 Query: 350 YFCA--QSMDNRIYSFSLKPKYKR-------------HPKKIFKGHSSAGYGISLAFSG- 393 C + D + + + + K+ G A + Sbjct: 342 ERCVSVGARDRTARYWKVPEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRV 401 Query: 394 ---DGRYICSGDSKSRLFTWDWNTSRLLNNI-KIPGNKP 428 D +G L W + L+ I + G +P Sbjct: 402 AMIDDDMFVTGSDNGDLALWSIQRKKPLHVIARAHGLEP 440 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 14/94 (14%), Positives = 36/94 (38%), Gaps = 4/94 (4%) Query: 361 YSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNN 420 K ++ K ++GH A + S DG+++ +G + RL ++ + + Sbjct: 226 RICFAKADARKANDKTYQGHLKAPLVVKA--SQDGKFVVTGGADKRLVVYNAADLKPIKA 283 Query: 421 IKIPGNKPITQVDWHPQETSKVICSGAAGKIYVC 454 +T + + + T+++ + V Sbjct: 284 F-TQHRDAVTGLAFR-RGTNQLYSCSKDRTVKVW 315 >5N4A-A nrPDB Length = 771 Score = 106 bits (265), Expect = 2e-23, Method: Composition-based stats. Identities = 38/293 (12%), Positives = 91/293 (31%), Gaps = 32/293 (10%) Query: 124 QGRGYLYPPNDVDVDLREERISFRCYL------------PKKVIRNYPG-----HPEGTT 166 Q ++ V F C P++ + H + Sbjct: 7 QSSANVHSELTAAVGWNVWNELFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPVS 66 Query: 167 ALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSF 226 + K + D ++KI + +GH +LR++ D + ++ Sbjct: 67 SKKTQAGGTDVFAVACTDGSVKI--LSRTGRVEKSIEGHKGACISLRWSYDGTALATAGE 124 Query: 227 DRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLV 286 D SVKIW G +++ L +P + + ++ ++ + Sbjct: 125 DGSVKIWS-RNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGSNVVIK----SLSSNAKQ 179 Query: 287 QTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHP 346 + H +L + + P I+ ED ++W++ + + + + + P Sbjct: 180 NAWKAHDGVVLKVDWSPINHLIITGGEDCKYKVWDSFGRLLFQSGLFD--YPVTSVAWAP 237 Query: 347 SQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYIC 399 S F + + Y + + G ++L+++ D + Sbjct: 238 SGELFAVGGFNTLQLCDRMGWAYSKIHL------NDTGSIMTLSWTADSTQLA 284 Score = 102 bits (254), Expect = 3e-22, Method: Composition-based stats. Identities = 43/259 (16%), Positives = 96/259 (37%), Gaps = 25/259 (9%) Query: 205 HNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHE-- 262 H++ A+ + + F + S D+++ W+ + L++ D+ P + + Sbjct: 13 HSELTAAVGWNVWNELF-TCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPVSSKKTQ 71 Query: 263 ------FIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKT 316 F V ++ + +S + ++ + H + ++L++ DG+ ++ ED + Sbjct: 72 AGGTDVFAVACTDGSVKI----LSRTGRVEKSIEGHKGACISLRWSYDGTALATAGEDGS 127 Query: 317 VRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKI 376 V+IW + + Q +C S + SL K++ K Sbjct: 128 VKIWSRNGMLRSTLAQADSPVYSIVWAYDCDQLCYCTGS---NVVIKSLSSNAKQNAWK- 183 Query: 377 FKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHP 436 + G + + +S I +G + WD L + + P+T V W P Sbjct: 184 ----AHDGVVLKVDWSPINHLIITGGEDCKYKVWDSFGRLLFQS--GLFDYPVTSVAWAP 237 Query: 437 QETSKVICSGAAGKIYVCD 455 ++ G + +CD Sbjct: 238 S--GELFAVGGFNTLQLCD 254 >4OWR-A nrPDB Length = 339 Score = 105 bits (261), Expect = 5e-23, Method: Composition-based stats. Identities = 45/304 (14%), Positives = 106/304 (34%), Gaps = 24/304 (7%) Query: 163 EGTTALKFLPKT--GHLILSGGNDHTIKIWDFYHDYECL-RDFQGHNKPIKALRFTEDCQ 219 + L F P T G+ +++G + ++ W+ + + + Q H P+ + +++D Sbjct: 11 DSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGS 70 Query: 220 SFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRV 279 ++S D++ K+WD + + ++ + + ++ S K L + D Sbjct: 71 KVFTASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTR 130 Query: 280 SENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVP-IKQISDTAQHS 338 S N +V + ++ ++ + +++ + ++I +H Sbjct: 131 SSNPMMVLQLPE---RCYCADVIYPMAVVATA--ERGLIVYQLENQPSEFRRIESPLKHQ 185 Query: 339 MPFLNVHPSQN----YFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGIS------ 388 + + + F S++ R+ + P FK H S G S Sbjct: 186 HRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIY 245 Query: 389 ----LAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVIC 444 +AF + + S R WD + L + +PI+ ++ Sbjct: 246 AVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLD-QPISACCFNHNGNIFAYA 304 Query: 445 SGAA 448 S Sbjct: 305 SSYD 308 Score = 89.1 bits (219), Expect = 4e-18, Method: Composition-based stats. Identities = 37/276 (13%), Positives = 77/276 (27%), Gaps = 67/276 (24%) Query: 161 HPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRF--TEDC 218 H + + G + + D T K+WD + H+ P+K + + + Sbjct: 56 HTGPVLDVCWS-DDGSKVFTASCDKTAKMWDLSSNQAI--QIAQHDAPVKTIHWIKAPNY 112 Query: 219 QSFLSSSFDRSVKIWDTETGKVKTRL---------------------------------- 244 ++ S+D+++K WDT + L Sbjct: 113 SCVMTGSWDKTLKFWDTRSSNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQP 172 Query: 245 -----------HLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHL 293 H + A + + P F +G ++ + T+ H Sbjct: 173 SEFRRIESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHR 232 Query: 294 SS------------ILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPF 341 S+ + + + P + D W+ +K Q + Sbjct: 233 SNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQ-PISA 291 Query: 342 LNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIF 377 + + N F S Y +S ++ KK + Sbjct: 292 CCFNHNGNIFAYASS----YDWSKGHEFYNPQKKNY 323 Score = 83.7 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 26/145 (17%), Positives = 56/145 (38%), Gaps = 9/145 (6%) Query: 239 KVKTRLHLNSTPADVESRPTN-PHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSIL 297 ++ + + + P P F++ S + + + Q + + H +L Sbjct: 2 DIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVL 61 Query: 298 ALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVH----PSQNYFCA 353 + + DGSK ++S DKT ++W+ N I+ AQH P +H P+ + Sbjct: 62 DVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQ----IAQHDAPVKTIHWIKAPNYSCVMT 117 Query: 354 QSMDNRIYSFSLKPKYKRHPKKIFK 378 S D + + + ++ + Sbjct: 118 GSWDKTLKFWDTRSSNPMMVLQLPE 142 >5WLC-LJ nrPDB Length = 513 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 48/282 (17%), Positives = 98/282 (34%), Gaps = 22/282 (7%) Query: 123 YQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGG 182 ++ G L D + + Y P+ ++ + T KF + ++ + Sbjct: 89 FRSDGKLLCAGDATGLVS----VYDSYNPRTILLSINASTHPTHVTKFHTQDNKILATAS 144 Query: 183 NDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDC-QSFLSSSFDRSVKIWDTET--GK 239 +D ++WD + YE + G ++ L F + S+D ++++DT + Sbjct: 145 DDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTRSSGST 204 Query: 240 VKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILAL 299 L+ + +V + IV + +D ++ ++ ++ L Sbjct: 205 PIYSLNHDQPVENVIAVSPTQ---IVSCGGNNFKVWDLTSNKKLYERGNFN---KAVTCL 258 Query: 300 KY-----FPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPS---QNYF 351 Y P S I+SS D V++++ N +K + + V PS N Sbjct: 259 DYVENFDSPMQSALIASSLDGHVKVFDPLDNFQVKFGWKFSG-PVLSCAVSPSTAQGNRH 317 Query: 352 CAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSG 393 + + + + K K KR K S S F Sbjct: 318 LVAGLSSGLLAIRTKKKEKRSSDKENAPASFNKNAKSNNFQR 359 Score = 101 bits (250), Expect = 9e-22, Method: Composition-based stats. Identities = 41/335 (12%), Positives = 113/335 (33%), Gaps = 31/335 (9%) Query: 130 YPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGH-LILSGGNDHTIK 188 P + R R Y ++++ + T + F P+ H ++ ++ Sbjct: 15 LLPQQTTPEQRYWR----QYTSAQLVKEH----NSVTHISFNPQHPHDFAVTSS--TRVQ 64 Query: 189 IWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKV-KTRLHLN 247 I+ + ++ F + + F D + + V ++D+ + ++ + Sbjct: 65 IFSSRT-RQVIKTFSRFKDVVYSASFRSDGKLLCAGDATGLVSVYDSYNPRTILLSINAS 123 Query: 248 STPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSK 307 + P V T ++ + S+ ++ D + + + + L + P Sbjct: 124 THPTHVTKFHTQDNKILATASDDRVTRLWDISNAYEPQL-ELTGATDYVRTLSFIPAAPH 182 Query: 308 FI-SSSEDKTVRIWENQINVPIKQISDTAQHSM-PFLNVHPSQNYFCAQSMDNRIYSFSL 365 + + S D +R+++ + + S + + V P+Q + +N + L Sbjct: 183 LVATGSYDGLIRLYDTRSSGSTPIYSLNHDQPVENVIAVSPTQ--IVSCGGNNF-KVWDL 239 Query: 366 KPKYKRHPKKIFKGHSSAGYGISLAFSGDG---RYICSGDSKSRLFTWD-WNTSRLLNNI 421 K + + F + A + + D + + + +D + ++ Sbjct: 240 TSNKKLYERGNF---NKAVTCLDYVENFDSPMQSALIASSLDGHVKVFDPLDNFQVKFGW 296 Query: 422 KIPGNKPITQVDWHP---QETSKVICSGAAGKIYV 453 K G P+ P Q ++ ++G + + Sbjct: 297 KFSG--PVLSCAVSPSTAQGNRHLVAGLSSGLLAI 329 Score = 87.2 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 31/228 (13%), Positives = 75/228 (32%), Gaps = 17/228 (7%) Query: 231 KIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYD 290 + W T + +++ + P +PH+F V S S + +++T+ Sbjct: 25 RYWRQYTSAQLVK--EHNSVTHISFNPQHPHDFAVTSST----RVQIFSSRTRQVIKTFS 78 Query: 291 HHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHP-SQN 349 + + + DG + V ++++ I + + H H Sbjct: 79 RFKDVVYSASFRSDGKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFHTQDNK 138 Query: 350 YFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICS-GDSKSRLF 408 S D + + Y+ + + Y +L+F ++ + G + Sbjct: 139 ILATASDDRVTRLWDISNAYEPQ----LELTGATDYVRTLSFIPAAPHLVATGSYDGLIR 194 Query: 409 TWDWNTSRLLNNIKIPGNKPITQV-DWHPQETSKVICSGAAGKIYVCD 455 +D +S + ++P+ V P ++++ G V D Sbjct: 195 LYDTRSSGSTPIYSLNHDQPVENVIAVSP---TQIVSCGG-NNFKVWD 238 >4E5Z-B nrPDB Length = 436 Score = 102 bits (253), Expect = 4e-22, Method: Composition-based stats. Identities = 48/349 (13%), Positives = 105/349 (30%), Gaps = 29/349 (8%) Query: 128 YLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTI 187 L + V ++ ++++ T+L + P + G I Sbjct: 85 KLGRASWPSVQQGLQQSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDI 144 Query: 188 KIWDF-YHDYECLRDFQGHNKPIKALRFTE-DCQSFLSSSFDRSVKIWDTETGKVKTRLH 245 +W+F D G I L+F + F +SS + + ++ D + G + Sbjct: 145 MLWNFGIKDKPTFIKGIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFK-GNILRVFA 203 Query: 246 LNSTP---ADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYF 302 + T + + G + ++ + E H + + Sbjct: 204 SSDTINIWFCSLDVSASSRMVVTGDNVGNVILLNMDGKELWN----LRMHKKKVTHVALN 259 Query: 303 PDGSKF-ISSSEDKTVRIWENQI--NVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNR 359 P F ++S D+TV+IW+ + S +H + P + Sbjct: 260 PCCDWFLATASVDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSE 319 Query: 360 IYSFSLKPKYKRHPKKIFK-GHSSAGYGISLAFSGDGRYICSG------------DSKSR 406 I +S H I A+ I G Sbjct: 320 IRVYSASQWDCPLGLIPHPHRHFQHLTPIKAAWHPRYNLIVVGRYPDPNFKSCTPYELRT 379 Query: 407 LFTWDWNTSRLLNNIKIPGNKPITQV-DWHPQETSKVICSGAAGKIYVC 454 + +D N+ +++ + P + I+ + +++P + + S I + Sbjct: 380 IDVFDGNSGKMMCQLYDPESSGISSLNEFNPMGDT--LASAMGYHILIW 426 >4U1E-I nrPDB Length = 347 Score = 102 bits (253), Expect = 4e-22, Method: Composition-based stats. Identities = 54/327 (16%), Positives = 100/327 (30%), Gaps = 44/327 (13%) Query: 158 YPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTED 217 GH T +K+ K G L+ S D + +W + + E L GH I ++ Sbjct: 6 LTGHERPLTQVKYN-KEGDLLFSCSKDSSASVW-YSLNGERLGTLDGHTGTIWSIDVDCF 63 Query: 218 CQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIV--------GL-- 267 + ++ S D S+K+WD G+ VE P + + G Sbjct: 64 TKYCVTGSADYSIKLWDVSNGQCVATWKSPVPVKRVEFSPCGNYFLAILDNVMKNPGSIN 123 Query: 268 -----SNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWEN 322 +S E + T++ L + + G I+ +D + ++ Sbjct: 124 IYEIERDSATHELTKVSEEPIHKIITHEG-LDAATVAGWSTKGKYIIAGHKDGKISKYDV 182 Query: 323 QINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRH---------- 372 N D + S+ + P YF S D + + Sbjct: 183 SNNYEYVDSIDLHEKSISDMQFSPDLTYFITSSRDTNSFLVDVSTLQVLKKYETDCPLNT 242 Query: 373 ------PKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGN 426 + I G ++ + +G++ ++ R+ + Sbjct: 243 AVITPLKEFIILGGGQEAKDVTTTSANEGKFEARFYH----KIFEEEIGRVQGHF----- 293 Query: 427 KPITQVDWHPQETSKVICSGAAGKIYV 453 P+ V PQ TS G G I + Sbjct: 294 GPLNTVAISPQGTSY-ASGGEDGFIRL 319 Score = 75.6 bits (184), Expect = 4e-14, Method: Composition-based stats. Identities = 33/181 (18%), Positives = 66/181 (36%), Gaps = 11/181 (6%) Query: 150 LPKKVIRNYPGHPE-GTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKP 208 + ++ I H + G I++G D I +D ++YE + H K Sbjct: 139 VSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKYDVSNNYEYVDSIDLHEKS 198 Query: 209 IKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLS 268 I ++F+ D F++SS D + + D T +V + + P + G Sbjct: 199 ISDMQFSPDLTYFITSSRDTNSFLVDVSTLQVLKKYETDCPLNTAVITPLKEFIILGGGQ 258 Query: 269 NSKIL--------HYDDRVSEN--QGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVR 318 +K + ++ R + + H + + P G+ + S ED +R Sbjct: 259 EAKDVTTTSANEGKFEARFYHKIFEEEIGRVQGHFGPLNTVAISPQGTSYASGGEDGFIR 318 Query: 319 I 319 + Sbjct: 319 L 319 Score = 68.7 bits (166), Expect = 4e-12, Method: Composition-based stats. Identities = 28/184 (15%), Positives = 55/184 (29%), Gaps = 23/184 (12%) Query: 288 TYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPS 347 H + +KY +G S S+D + +W + + + D ++ ++V Sbjct: 5 KLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTL-DGHTGTIWSIDVDCF 63 Query: 348 QNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSK--- 404 Y S D I + + K S + FS G Y + Sbjct: 64 TKYCVTGSADYSIKLWDVSNGQCVATWK------SPVPVKRVEFSPCGNYFLAILDNVMK 117 Query: 405 --SRLFTWDWNTSRLLNNIKIPGNKPITQVDWH-----------PQETSKVICSGAAGKI 451 + ++ + + +PI ++ H + +I GKI Sbjct: 118 NPGSINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKI 177 Query: 452 YVCD 455 D Sbjct: 178 SKYD 181 Score = 37.1 bits (84), Expect = 0.018, Method: Composition-based stats. Identities = 12/84 (14%), Positives = 20/84 (23%), Gaps = 8/84 (9%) Query: 375 KIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDW 434 K K + ++ +G + S S W L + W Sbjct: 2 KAIKLTGHERPLTQVKYNKEGDLLFSCSKDSSASVWYSLNGERLGTLDGHTGT-----IW 56 Query: 435 HPQE---TSKVICSGAAGKIYVCD 455 T + A I + D Sbjct: 57 SIDVDCFTKYCVTGSADYSIKLWD 80 >4PSX-B nrPDB Length = 401 Score = 101 bits (251), Expect = 7e-22, Method: Composition-based stats. Identities = 43/289 (14%), Positives = 98/289 (33%), Gaps = 27/289 (9%) Query: 111 EVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKF 170 ++ Y E+ + R Y+ ++ + + +F + + H + AL F Sbjct: 110 RITAKYEHEEEITRAR-YMPQDPNIVATINGQGTTFLYSRSEGLQSTLKFHKDNGYALSF 168 Query: 171 LPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQG----HNKPIKALRFTE-DCQSFLSSS 225 +LSG +DHT+ +W+ + + + H+ I ++ + F + S Sbjct: 169 STLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVS 228 Query: 226 FDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLS-NSKILHYDDRVSENQG 284 D +KI D P + + + + +S + YD R + Sbjct: 229 EDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNM--KE 286 Query: 285 LVQTYDHHLSSILALKYFPDGS-KFISSSEDKTVRIWENQINVPIKQ------------- 330 + H ++ L++ +SS D + +W+ + + Sbjct: 287 PLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIM 346 Query: 331 ISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKG 379 + + S+ +++P + A + + I L+ H I G Sbjct: 347 VHAGHRSSVNDFDLNPQIPWLVASAEEENI----LQVWKCSHSLPIVGG 391 Score = 78.7 bits (192), Expect = 4e-15, Method: Composition-based stats. Identities = 48/271 (17%), Positives = 87/271 (32%), Gaps = 26/271 (9%) Query: 204 GHNKPIKALRFTE-DCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHE 262 H + I R+ D + + + ++ G T + Sbjct: 116 EHEEEITRARYMPQDPNIVATINGQGTTFLYSRSEGLQSTLKFHKDNGYALSFSTLVKGR 175 Query: 263 FIVGLSNSKILHYDDRVSENQ-GLVQTY-DHHLSSILALKYFP-DGSKFISSSEDKTVRI 319 + G + + ++ + V+T+ D H I K+ + F + SED ++I Sbjct: 176 LLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKDLFGTVSEDSLLKI 235 Query: 320 WENQINVPIKQISDTAQHSMPFLNV---HPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKI 376 + + N DT + PF + H S N A MD+ +Y + L+ + P Sbjct: 236 NDVRAN---NTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNM--KEPLHH 290 Query: 377 FKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNN-------------IKI 423 GH A + + DG + SG +RL WD + Sbjct: 291 MSGHEDAVNNLEFSTHVDGVVVSSGS-DNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHA 349 Query: 424 PGNKPITQVDWHPQETSKVICSGAAGKIYVC 454 + D +PQ V + + V Sbjct: 350 GHRSSVNDFDLNPQIPWLVASAEEENILQVW 380 >6EM1-m nrPDB Length = 807 Score = 99.1 bits (245), Expect = 3e-21, Method: Composition-based stats. Identities = 70/469 (14%), Positives = 144/469 (30%), Gaps = 105/469 (22%) Query: 82 ASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRG---YLYP-PNDVDV 137 S +KE + ++ E N ++ YG+S ++ R YL P + Sbjct: 346 LSPEEKEAWENTEYSERERNFIPQKYSALRKVPGYGESIRERFERSLDLYLAPRVRKNKL 405 Query: 138 DLREERISFRCYLPK-------KVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIW 190 ++ + PK + Y GH L P +G + +G +D T+++W Sbjct: 406 NIDPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDP-SGLWLATGSDDGTVRVW 464 Query: 191 DFYHDYECLRDF-----QGHNKPIKALRFTED-CQSFLSSSFDRSVKI-------WDTE- 236 + E R + + I+ + + D L+ + ++ + +D E Sbjct: 465 EILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIEN 524 Query: 237 TGKVKTRLHLNSTPADVESRPT------------NPHEFIVGLSNSKILHYDD---RVSE 281 GK K + +E ++ ++ + E Sbjct: 525 NGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLE 584 Query: 282 NQGLVQTYDHHLSSILALKYFPDGSKFISSSED--------------------------- 314 + ++ L + G F++ D Sbjct: 585 KDICITISC--KKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGII 642 Query: 315 -----------------KTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMD 357 + VRI++ + +K++ A+ + +++HP + A S D Sbjct: 643 MDAKFHPFKPQLFVCSQRYVRIYDLSQQILVKKLLPGAR-WLSKIDIHPRGDNLIASSFD 701 Query: 358 NRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLF-----TWD- 411 R+ L P K + H A S+ F S + +D Sbjct: 702 KRVLWHDLD--LASTPYKTLRYHEKAVR--SVNFHKKLPLFSSAADDGTIHVFHATVYDD 757 Query: 412 -WNTSRLLNNIKIPGNKPITQV-----DWHPQETSKVICSGAAGKIYVC 454 ++ K+ G+K I + WHP+E + + +GA + Sbjct: 758 MMKNPMIVPLKKLTGHKVINSLGVLDAIWHPRE-AWLFSAGADNTARLW 805 Score = 73.7 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 49/327 (14%), Positives = 101/327 (30%), Gaps = 69/327 (21%) Query: 5 DGYDTSSDSDLNFDEGKSVHEKKNGNLHEDTSYEPSSNNIHKRKSHFTKSELKRRRKTR- 63 D + T S+L +E NG+ ED E + N + K+ + + K K+ K Sbjct: 537 DTFGTVKKSNLEVNE--------NGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDIC 588 Query: 64 -----KGDGPWGSWSSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGK 118 K SW D Q + + V ++ + Sbjct: 589 ITISCKKTVKKLSWHRKGDY---FVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDA 645 Query: 119 SEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLI 178 ++ + ++ V + ++I + LP + + P+ +LI Sbjct: 646 KFHPFKPQLFVCSQRYVRIYDLSQQILVKKLLPG---------ARWLSKIDIHPRGDNLI 696 Query: 179 LSGGNDHTIKIW-DFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTET 237 S D + +W D + + H K ++++ F + F S++ D ++ + Sbjct: 697 AS-SFDKRV-LWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHV----- 749 Query: 238 GKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLS--- 294 ++T D D + ++ H Sbjct: 750 --------FHATVYD-----------------------DMMKNPMIVPLKKLTGHKVINS 778 Query: 295 -SILALKYFPDGSKFISSSEDKTVRIW 320 +L + P + S+ D T R+W Sbjct: 779 LGVLDAIWHPREAWLFSAGADNTARLW 805 >3W15-A nrPDB Length = 368 Score = 98.4 bits (243), Expect = 6e-21, Method: Composition-based stats. Identities = 42/317 (13%), Positives = 98/317 (30%), Gaps = 46/317 (14%) Query: 167 ALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQS-FLSSS 225 L + + +L D T++++D + F+ H + + + + + FLSSS Sbjct: 67 DLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQNFLSSS 126 Query: 226 FDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGL 285 +D S+KIW + L P N + + Sbjct: 127 WDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLN------------------AIILKKKS 168 Query: 286 VQTYDHHLSSILALKYFP-DGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFL-- 342 + + + ++ P D + +S S + +++ ++ Q + + L Sbjct: 169 FTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTC 228 Query: 343 NVHPSQNYFCA-QSMDNRIYSFSLK-----PKYKRHPKKIFK-GHSSAGYGISLAFSG-D 394 + + + Y A +DN I + ++ P + I + ++ + +S Sbjct: 229 DFNKYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHH 288 Query: 395 GRYICSGDSKSRLFTW-DWNTSRLLNNIKIPGNKPITQVDWHPQETS------------- 440 + S W D + K ++ + S Sbjct: 289 SNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGK 348 Query: 441 --KVICSGAAGKIYVCD 455 V + G ++V + Sbjct: 349 PGYVASTAWDGNLFVWN 365 Score = 89.9 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 52/317 (16%), Positives = 95/317 (29%), Gaps = 76/317 (23%) Query: 136 DVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD 195 D LR +F+ + I + H + + LS D +IKIW Sbjct: 84 DGTLRLFDTTFKEF----PIAIFKEHEREVFSCNWNLVNRQNFLSSSWDGSIKIWSPLRK 139 Query: 196 YECL-----------------------RDFQGHNKPIKAL---RFTE-DCQSFLSSSFDR 228 + + F G +K + +F+ D LS S + Sbjct: 140 QSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNS 199 Query: 229 SVKIWDTE--TGKVKTRLHLNST--PADVESRPTNPHEFIVGLSNSKILHYDDR------ 278 ++D +GK + ++S + P+ G ++ I +D R Sbjct: 200 YASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNP 259 Query: 279 -VSENQGLVQT-YDHHLSSILALKYFPDGSKFI-SSSEDKTVRIW-ENQINVPIKQISDT 334 N + + H +I + + P S + S+S D T RIW + + + Sbjct: 260 GQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTN 319 Query: 335 AQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGD 394 + + + +Q+ D +SL K Sbjct: 320 STDATKGSIFNFTQHSEFVFGAD-----WSLWGKPG------------------------ 350 Query: 395 GRYICSGDSKSRLFTWD 411 Y+ S LF W+ Sbjct: 351 --YVASTAWDGNLFVWN 365 Score = 63.3 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 24/132 (18%), Positives = 49/132 (37%), Gaps = 23/132 (17%) Query: 126 RGYLYPPNDVDVDLREERISFRCYLPKK-----VIRNYP-GHPEGTTALKFLPKTGHLIL 179 R Y+ VD +R I P + I P H + + P ++++ Sbjct: 234 RPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILM 293 Query: 180 SGGNDHTIKIW-DFYHDY--ECLRD------------FQGHNKPIKALRFTEDCQ--SFL 222 S D T +IW D +D E + F H++ + ++ + Sbjct: 294 SASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVA 353 Query: 223 SSSFDRSVKIWD 234 S+++D ++ +W+ Sbjct: 354 STAWDGNLFVWN 365 >5BJS-A nrPDB Length = 605 Score = 98.0 bits (242), Expect = 7e-21, Method: Composition-based stats. Identities = 32/179 (17%), Positives = 64/179 (35%), Gaps = 42/179 (23%) Query: 152 KKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYE-----CLRDFQGHN 206 K+ R GH G L P ++I S +D TI+IW ++E C+ +GH+ Sbjct: 168 GKLYRTLVGHGGGINDLATSPANPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHS 227 Query: 207 KPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVG 266 + ++ F ++ + LS+ D+ + +W + P + + E Sbjct: 228 YDLLSVAFHDNGRYVLSAGHDQVINLWAL----PEFPNEHMEIPIVIYYPHFSSSEI--- 280 Query: 267 LSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFIS--SSEDKTVRIWENQ 323 H + + + ++ G +S ED T+ +W + Sbjct: 281 -------------------------HNNLVDCVAFY--GDLILSRACHED-TIVLWRIE 311 Score = 73.7 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 21/175 (12%), Positives = 65/175 (37%), Gaps = 23/175 (13%) Query: 213 RFTED----CQSFLSSSFDRSVKIWDTETGKVKTRLHLNST-PADVESRPTNPHEFIVGL 267 +++D + + +VK+++ GK+ L + D+ + P NP+ Sbjct: 139 CWSKDPITDQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASAS 198 Query: 268 SNSKILHYDDR---VSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQ- 323 ++ I + + + + H +L++ + +G +S+ D+ + +W Sbjct: 199 DDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPE 258 Query: 324 -----------INVPIKQISDTAQHSMPFLNVHPSQNYFCAQSM-DNRIYSFSLK 366 I P S+ + + + + + +++ ++ I + ++ Sbjct: 259 FPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAFY--GDLILSRACHEDTIVLWRIE 311 Score = 71.0 bits (172), Expect = 1e-12, Method: Composition-based stats. Identities = 28/187 (14%), Positives = 57/187 (30%), Gaps = 13/187 (6%) Query: 236 ETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYD-----DRVSENQGLVQTYD 290 + G V L P S + D+ + ++Q Sbjct: 69 DDGSVSQDLAEFFDVKFYPYSPPGAPPVFAATSKKHAVICRLTQTTDKDANPCEIIQLIR 128 Query: 291 HHLSSILALK-YF----PDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVH 345 + + D + + V+++ + + + L Sbjct: 129 DDGNEANCASCWSKDPITDQPLLCIAGNEGNVKVYNVTEGKLYRTL-VGHGGGINDLATS 187 Query: 346 P-SQNYFCAQSMDNRIYSFSLKPKYKRHP-KKIFKGHSSAGYGISLAFSGDGRYICSGDS 403 P + + S D I +SL P++++ P I G + +S+AF +GRY+ S Sbjct: 188 PANPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGH 247 Query: 404 KSRLFTW 410 + W Sbjct: 248 DQVINLW 254 Score = 68.3 bits (165), Expect = 7e-12, Method: Composition-based stats. Identities = 34/167 (20%), Positives = 54/167 (32%), Gaps = 18/167 (10%) Query: 258 TNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKF-ISSSEDKT 316 T+ + + + Y+ L +T H I L P S+S+D T Sbjct: 146 TDQPLLCIAGNEGNVKVYNVTEG---KLYRTLVGHGGGINDLATSPANPYIIASASDDTT 202 Query: 317 VRIWENQ---INVPIKQISDTAQHS--MPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKR 371 +RIW P I HS + + H + Y + D I ++L Sbjct: 203 IRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQVINLWALPEFPNE 262 Query: 372 H---PKKIFKGHSSAGY-----GISLAFSGDGRYICSGDSKSRLFTW 410 H P I+ H S+ +AF GD + + W Sbjct: 263 HMEIPIVIYYPHFSSSEIHNNLVDCVAFYGDLILSRACHED-TIVLW 308 Score = 53.7 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 23/127 (18%), Positives = 40/127 (31%), Gaps = 17/127 (13%) Query: 124 QGRGYLYPPNDVDVDLREERISFR-CYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGG 182 Y+ D +R ++ P I GH ++ F G +LS G Sbjct: 188 PANPYIIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFH-DNGRYVLSAG 246 Query: 183 NDHTIKIWDFYH------------DYECLRDFQGHNKPIKALRFTEDCQSFLS-SSFDRS 229 +D I +W Y + HN + + F LS + + + Sbjct: 247 HDQVINLWALPEFPNEHMEIPIVIYYPHFSSSEIHNNLVDCVAFY--GDLILSRACHEDT 304 Query: 230 VKIWDTE 236 + +W E Sbjct: 305 IVLWRIE 311 >3ACP-A nrPDB Length = 417 Score = 96.4 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 43/252 (17%), Positives = 80/252 (31%), Gaps = 28/252 (11%) Query: 159 PGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDC 218 H T LKF P +G ++S D +KIW R GH + + + Sbjct: 133 QAHVSEITKLKFFP-SGEALISSSQDMQLKIWSVKDGSNP-RTLIGHRATVTDIAIIDRG 190 Query: 219 QSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDR 278 ++ LS+S D ++++W+ TG + P D N VG Sbjct: 191 RNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGV----NSIALFVGTDR--------- 237 Query: 279 VSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHS 338 Q ++ S L++ G I+ + + Q+ S Sbjct: 238 --------QLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLPSKFTCS 289 Query: 339 MPFLNVH-PSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRY 397 L V + NY A + + + L+ + + + ++ F+ G Sbjct: 290 CNSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVGEFLI---NEGTPINNVYFAA-GAL 345 Query: 398 ICSGDSKSRLFT 409 S + + Sbjct: 346 FVSSGFDTSIKL 357 Score = 77.5 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 51/305 (16%), Positives = 88/305 (28%), Gaps = 71/305 (23%) Query: 213 RFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKI 272 F + + D +++T L A V++ FI+G + I Sbjct: 60 TFEKVGSHLYKARLDGHDFLFNTIIRDGSKMLKRADYTA-VDTAKLQMRRFILGTTEGDI 118 Query: 273 LHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQIS 332 D + + + Q H+S I LK+FP G ISSS+D ++IW + + + Sbjct: 119 KVLDSNFNLQREIDQA---HVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTLI 175 Query: 333 DTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHP------------------- 373 + ++ + + + S+D I + H Sbjct: 176 -GHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALFVG 234 Query: 374 ----------------------KKIFKGHSSAG---------------------YGISLA 390 K + GH S SL Sbjct: 235 TDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLPSKFTCSCNSLT 294 Query: 391 FSGD-GRYICSGDSKSRLFTWDWNTSRL-LNNIKIPGNKPITQVDWHPQETSKVICSGAA 448 G+ YI +G L WD + + I PI V + + + SG Sbjct: 295 VDGNNANYIYAGYENGMLAQWDLRSPECPVGEFLINEGTPINNVYF--AAGALFVSSGFD 352 Query: 449 GKIYV 453 I + Sbjct: 353 TSIKL 357 Score = 43.7 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 16/105 (15%), Positives = 29/105 (27%), Gaps = 7/105 (6%) Query: 351 FCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTW 410 F + + I +R I + H S L F G + S +L W Sbjct: 109 FILGTTEGDIKVLDSNFNLQRE---IDQAHVSE--ITKLKFFPSGEALISSSQDMQLKIW 163 Query: 411 DWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 + +T + V+ + G I + + Sbjct: 164 SVKDGSNPRTLIGHRAT-VTDIAI-IDRGRNVLSASLDGTIRLWE 206 >6BX3-B nrPDB Length = 412 Score = 95.7 bits (236), Expect = 4e-20, Method: Composition-based stats. Identities = 46/314 (14%), Positives = 100/314 (31%), Gaps = 30/314 (9%) Query: 167 ALKFLPKTGHLILSGGNDHTIKIWDFYHDYE---CLRDFQGHNKPIKALRFTEDCQSFLS 223 L+F P G + G + + I+D H +PI ++ ++ D + L+ Sbjct: 30 CLQFSPC-GDYLALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLT 88 Query: 224 SSFDRSVKIWDTET-GKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSE- 281 SS D S+K+WD K + +S + + + + D ++ Sbjct: 89 SSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDP 148 Query: 282 --------NQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTV----RIWENQINVPIK 329 ++ + + H +L I K + I Sbjct: 149 VASLLSKSDEKQLSSTPDH-GYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQTECIH 207 Query: 330 QISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISL 389 + T+ + + L V + D I + + + ++ H L Sbjct: 208 SLKITSSN-IKHLIVSQNGERLAINCSDRTIRQYEISIDDENSAVELTLEHKYQDVINKL 266 Query: 390 AFSG------DGRYICS---GDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETS 440 ++ Y+ + G S L+ W+ + L+ ++ + + ++W S Sbjct: 267 QWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLVRVLEG-AEEELIDINWDFYSMS 325 Query: 441 KVICSGAAGKIYVC 454 V +G +YV Sbjct: 326 IVSNGFESGNVYVW 339 Score = 49.8 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 23/90 (25%), Positives = 37/90 (41%), Gaps = 4/90 (4%) Query: 369 YKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSR---LLNNIKIPG 425 K HP+K+ + L FS G Y+ G + L +D +T R + N+ Sbjct: 11 LKEHPEKLTHTIENPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVPGNMLGAH 70 Query: 426 NKPITQVDWHPQETSKVICSGAAGKIYVCD 455 +PIT + W P ++ S I + D Sbjct: 71 VRPITSIAWSPD-GRLLLTSSRDWSIKLWD 99 >6CB1-s nrPDB Length = 569 Score = 93.3 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 57/389 (14%), Positives = 118/389 (30%), Gaps = 94/389 (24%) Query: 151 PKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDF-----QGH 205 P + Y GH L P +G + +G +D T+++W+ E R + Sbjct: 188 PIRCSTIYAGHKGKVRTLSIDP-SGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENP 246 Query: 206 NKPIKALRFTED-CQSFLSSSFDRSVKI-------WDTE-TGKVKTRLHLNSTPADVESR 256 + I+ + + D L+ + ++ + +D E GK K + Sbjct: 247 DYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKK 306 Query: 257 PT------------NPHEFIVGLSNSKILHYDD---RVSENQGLVQTYDHHLSSILALKY 301 +E ++ ++ + E + ++ L + Sbjct: 307 SNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISC--KKTVKKLSW 364 Query: 302 FPDGSKFISSSED--------------------------------------------KTV 317 G F++ D + V Sbjct: 365 HRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYV 424 Query: 318 RIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIF 377 RI++ + +K++ A+ + +++HP + A S D R+ L P K Sbjct: 425 RIYDLSQQILVKKLLPGAR-WLSKIDIHPRGDNLIASSFDKRVLWHDLD--LASTPYKTL 481 Query: 378 KGHSSAGYGISLAFSGDGRYICSGDSKSRLF-----TWD--WNTSRLLNNIKIPGNKPIT 430 + H A S+ F S + +D ++ K+ G+K I Sbjct: 482 RYHEKAVR--SVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVIN 539 Query: 431 QV-----DWHPQETSKVICSGAAGKIYVC 454 + WHP+E + + +GA + Sbjct: 540 SLGVLDAIWHPRE-AWLFSAGADNTARLW 567 Score = 75.2 bits (183), Expect = 6e-14, Method: Composition-based stats. Identities = 49/327 (14%), Positives = 101/327 (30%), Gaps = 69/327 (21%) Query: 5 DGYDTSSDSDLNFDEGKSVHEKKNGNLHEDTSYEPSSNNIHKRKSHFTKSELKRRRKTR- 63 D + T S+L +E NG+ ED E + N + K+ + + K K+ K Sbjct: 299 DTFGTVKKSNLEVNE--------NGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDIC 350 Query: 64 -----KGDGPWGSWSSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGK 118 K SW D Q + + V ++ + Sbjct: 351 ITISCKKTVKKLSWHRKGDY---FVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDA 407 Query: 119 SEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLI 178 ++ + ++ V + ++I + LP + + P+ +LI Sbjct: 408 KFHPFKPQLFVCSQRYVRIYDLSQQILVKKLLPG---------ARWLSKIDIHPRGDNLI 458 Query: 179 LSGGNDHTIKIW-DFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTET 237 S D + +W D + + H K ++++ F + F S++ D ++ + Sbjct: 459 AS-SFDKRV-LWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHV----- 511 Query: 238 GKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLS--- 294 ++T D D + ++ H Sbjct: 512 --------FHATVYD-----------------------DMMKNPMIVPLKKLTGHKVINS 540 Query: 295 -SILALKYFPDGSKFISSSEDKTVRIW 320 +L + P + S+ D T R+W Sbjct: 541 LGVLDAIWHPREAWLFSAGADNTARLW 567 >6CHG-D nrPDB Length = 439 Score = 93.0 bits (229), Expect = 3e-19, Method: Composition-based stats. Identities = 52/340 (15%), Positives = 116/340 (34%), Gaps = 44/340 (12%) Query: 151 PKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYH--DYECLRDFQG-HNK 207 P+K+ +KF P+ G + G ++ I I+D L G H + Sbjct: 17 PEKLTHTLEVPVAAV-CVKFSPR-GDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAHTR 74 Query: 208 PIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKT-----------RLHLNSTPADVESR 256 ++++ ++ D + SS D K+WD T K H+ + + Sbjct: 75 SVQSVCWSNDGRYLWSSGRDWYAKLWDM-TQPTKCFQQYKFDGPLWSCHVVRWNVCIVTV 133 Query: 257 PTNPHEFIVGLSN-SKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDK 315 P +++ L++ H + ++Q + H +++A + S I+ + Sbjct: 134 VEEPTAYVLTLTDRQNAFHCFPLLEQDQDI----SGHGYTLVACPHPTIESIIITGTSKG 189 Query: 316 TVRIWENQI------NVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKY 369 + ++ + + A ++ + + PS D I + L + Sbjct: 190 WINAFQLDLESGFEDKIRCCYEEKIANANIKQIIISPSGTRIAINGSDRTIRQYQLIVED 249 Query: 370 KR------HPKKIFKGHSSAGYGISLAFSG------DGRYICS---GDSKSRLFTWDWNT 414 H I H L ++ G Y+ + G S L+ W+ ++ Sbjct: 250 NESEGGSSHSVSIELEHKYQDIINRLQWNTIFFSNHSGEYLVASAHGSSAHDLYLWETSS 309 Query: 415 SRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVC 454 L+ ++ + + +DW+ +G +Y+ Sbjct: 310 GSLVRVLEGAD-EELLDIDWNFYSMRIASNGFESGWVYMW 348 Score = 43.7 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 16/90 (17%), Positives = 33/90 (36%), Gaps = 4/90 (4%) Query: 369 YKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSR---LLNNIKIPG 425 K +P+K+ + + FS G Y+ G S + +D ++ + +L Sbjct: 13 LKEYPEKLTHTLEVPVAAVCVKFSPRGDYLAVGCSNGAIIIYDMDSLKPIAMLGTHSGAH 72 Query: 426 NKPITQVDWHPQETSKVICSGAAGKIYVCD 455 + + V W + + SG + D Sbjct: 73 TRSVQSVCWS-NDGRYLWSSGRDWYAKLWD 101 >4G56-B nrPDB Length = 357 Score = 92.2 bits (227), Expect = 4e-19, Method: Composition-based stats. Identities = 39/254 (15%), Positives = 93/254 (36%), Gaps = 19/254 (7%) Query: 206 NKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKV----KTRLHLNSTPADVESRPTNPH 261 + + + + + +S +V++W+ + K + + S ++ Sbjct: 94 EAGVTDVAWVSEKGILV-ASDSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSDGT 152 Query: 262 EFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFP-DGSKFISSSEDKTVRIW 320 + + G + + +D + ++++Y+ H S + + P + F+S ED + +W Sbjct: 153 QAVSGGKDFSVKVWDLSQ---KAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLW 209 Query: 321 ENQINVPIKQISDTAQHSMP-FLNVHP-SQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFK 378 + + P +I A ++P + HP + F + ++K +P Sbjct: 210 DTRKPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNVSLVNIK-----NPDSAQT 264 Query: 379 GHSSAGYGISLAFSG-DGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQ 437 + LA+S ++ S + D + S + + +T V W P Sbjct: 265 SAVHSQNITGLAYSYHSSPFLASISEDCTVAVLDADFSEVFR--DLSHRDFVTGVAWSPL 322 Query: 438 ETSKVICSGAAGKI 451 + SK G K+ Sbjct: 323 DHSKFTTVGWDHKV 336 Score = 86.8 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 44/253 (17%), Positives = 88/253 (34%), Gaps = 17/253 (6%) Query: 162 PEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECL-RDFQ--GHNKPIKALRFTEDC 218 G T + ++ + G L+ S +++W+ L F H+ +K L D Sbjct: 94 EAGVTDVAWVSEKGILVASDS--GAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFSDG 151 Query: 219 QSFLSSSFDRSVKIWDTETGKVKTRLHLNST-PADVESRPTNPHEFIVGLSNSKILHYDD 277 +S D SVK+WD V + +S+ V + P F+ + +IL +D Sbjct: 152 TQAVSGGKDFSVKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDT 211 Query: 278 RVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIK-QISDTAQ 336 R + + ++ + P+ + D+T + I P Q S Sbjct: 212 RKPKPATRIDFCASDTIP-TSVTWHPEKDDTFACG-DETGNVSLVNIKNPDSAQTSAVHS 269 Query: 337 HSMPFLNVHP-SQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSG-D 394 ++ L S + + S D + ++F+ S + +A+S D Sbjct: 270 QNITGLAYSYHSSPFLASISEDCTVAVLDADFS------EVFRDLSHRDFVTGVAWSPLD 323 Query: 395 GRYICSGDSKSRL 407 + ++ Sbjct: 324 HSKFTTVGWDHKV 336 Score = 78.3 bits (191), Expect = 6e-15, Method: Composition-based stats. Identities = 39/211 (18%), Positives = 64/211 (30%), Gaps = 47/211 (22%) Query: 152 KKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKA 211 K V+++Y H + P + LS G D I +WD KP Sbjct: 171 KAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTRKP-----------KPATR 219 Query: 212 LRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSK 271 + F ++ P V P F G Sbjct: 220 IDFC-----------------------------ASDTIPTSVTWHPEKDDTFACGDETGN 250 Query: 272 ILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKF-ISSSEDKTVRIWENQINVPIKQ 330 + + + N QT H +I L Y S F S SED TV + + + + Sbjct: 251 VSLVNIK---NPDSAQTSAVHSQNITGLAYSYHSSPFLASISEDCTVAVLDADFSEVFRD 307 Query: 331 ISDTAQHSMPFLNVHP-SQNYFCAQSMDNRI 360 +S + + + P + F D+++ Sbjct: 308 LS--HRDFVTGVAWSPLDHSKFTTVGWDHKV 336 Score = 65.2 bits (157), Expect = 6e-11, Method: Composition-based stats. Identities = 30/182 (16%), Positives = 59/182 (32%), Gaps = 9/182 (4%) Query: 276 DDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPI---KQIS 332 D + N+ L + + + + + + +S+ V +WE + K Sbjct: 77 DPEGAPNESLCTAGVQTEAGVTDVAWVSE-KGILVASDSGAVELWEILEKESLLVNKFAK 135 Query: 333 DTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFS 392 + L+V + D + + L ++ K + HSS ++ Sbjct: 136 YEHDDIVKTLSVFSDGTQAVSGGKDFSVKVWDL---SQKAVLKSYNAHSSEVNCVAACPG 192 Query: 393 GDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPI-TQVDWHPQETSKVICSGAAGKI 451 D S R+ WD + I + I T V WHP++ C G + Sbjct: 193 KD-TIFLSCGEDGRILLWDTRKPKPATRIDFCASDTIPTSVTWHPEKDDTFACGDETGNV 251 Query: 452 YV 453 + Sbjct: 252 SL 253 Score = 52.9 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 19/109 (17%), Positives = 38/109 (34%), Gaps = 2/109 (1%) Query: 347 SQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSR 406 S+ S + + + K K F + +L+ DG SG Sbjct: 104 SEKGILVASDSGAVELWEILEKESLLVNK-FAKYEHDDIVKTLSVFSDGTQAVSGGKDFS 162 Query: 407 LFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 + WD + +L + ++ + V P + + + G G+I + D Sbjct: 163 VKVWDLSQKAVLKSYNAHSSE-VNCVAACPGKDTIFLSCGEDGRILLWD 210 >6C0F-s nrPDB Length = 807 Score = 91.8 bits (226), Expect = 5e-19, Method: Composition-based stats. Identities = 57/389 (14%), Positives = 118/389 (30%), Gaps = 94/389 (24%) Query: 151 PKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDF-----QGH 205 P + Y GH L P +G + +G +D T+++W+ E R + Sbjct: 426 PIRCSTIYAGHKGKVRTLSIDP-SGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENP 484 Query: 206 NKPIKALRFTED-CQSFLSSSFDRSVKI-------WDTE-TGKVKTRLHLNSTPADVESR 256 + I+ + + D L+ + ++ + +D E GK K + Sbjct: 485 DYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKK 544 Query: 257 PT------------NPHEFIVGLSNSKILHYDD---RVSENQGLVQTYDHHLSSILALKY 301 +E ++ ++ + E + ++ L + Sbjct: 545 SNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISC--KKTVKKLSW 602 Query: 302 FPDGSKFISSSED--------------------------------------------KTV 317 G F++ D + V Sbjct: 603 HRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYV 662 Query: 318 RIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIF 377 RI++ + +K++ A+ + +++HP + A S D R+ L P K Sbjct: 663 RIYDLSQQILVKKLLPGAR-WLSKIDIHPRGDNLIASSFDKRVLWHDLD--LASTPYKTL 719 Query: 378 KGHSSAGYGISLAFSGDGRYICSGDSKSRLF-----TWD--WNTSRLLNNIKIPGNKPIT 430 + H A S+ F S + +D ++ K+ G+K I Sbjct: 720 RYHEKAVR--SVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVIN 777 Query: 431 QV-----DWHPQETSKVICSGAAGKIYVC 454 + WHP+E + + +GA + Sbjct: 778 SLGVLDAIWHPRE-AWLFSAGADNTARLW 805 Score = 73.7 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 49/327 (14%), Positives = 101/327 (30%), Gaps = 69/327 (21%) Query: 5 DGYDTSSDSDLNFDEGKSVHEKKNGNLHEDTSYEPSSNNIHKRKSHFTKSELKRRRKTR- 63 D + T S+L +E NG+ ED E + N + K+ + + K K+ K Sbjct: 537 DTFGTVKKSNLEVNE--------NGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDIC 588 Query: 64 -----KGDGPWGSWSSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGK 118 K SW D Q + + V ++ + Sbjct: 589 ITISCKKTVKKLSWHRKGDY---FVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDA 645 Query: 119 SEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLI 178 ++ + ++ V + ++I + LP + + P+ +LI Sbjct: 646 KFHPFKPQLFVCSQRYVRIYDLSQQILVKKLLPG---------ARWLSKIDIHPRGDNLI 696 Query: 179 LSGGNDHTIKIW-DFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTET 237 S D + +W D + + H K ++++ F + F S++ D ++ + Sbjct: 697 AS-SFDKRV-LWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHV----- 749 Query: 238 GKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLS--- 294 ++T D D + ++ H Sbjct: 750 --------FHATVYD-----------------------DMMKNPMIVPLKKLTGHKVINS 778 Query: 295 -SILALKYFPDGSKFISSSEDKTVRIW 320 +L + P + S+ D T R+W Sbjct: 779 LGVLDAIWHPREAWLFSAGADNTARLW 805 >5YZG-2 nrPDB Length = 646 Score = 91.0 bits (224), Expect = 9e-19, Method: Composition-based stats. Identities = 50/304 (16%), Positives = 98/304 (32%), Gaps = 36/304 (11%) Query: 81 QASETQKE-DQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDL 139 + E + A+A + E+ E V ++ L V L Sbjct: 19 PEEPEKTELSERELAVAVAVSQENDEENEERWVGPLPVEAT--------LAKKRKV---L 67 Query: 140 REERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIW-DFYHDYEC 198 ER+ + H + T + + I++ +D +K W E Sbjct: 68 EFERVYLDNLPSASMYERSYMHRDVITHV--VCTKTDFIITASHDGHVKFWKKIEEGIEF 125 Query: 199 LRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVES--R 256 ++ F+ H I+++ + + F S D+++K++D + L L P E Sbjct: 126 VKHFRSHLGVIESIAVSSEGALFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYC 185 Query: 257 PTNPHEFIVGL--SNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSED 314 P + + S KI YD R +NQ L H S + ++ P +SS + Sbjct: 186 PGDAISSVAASEKSTGKIFIYDGR-GDNQPLHIFDKLHTSPLTQIRLNPVYKAVVSSDKS 244 Query: 315 KTV---------------RIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNR 359 + WE + + + + + + + P D + Sbjct: 245 GMIEYWTGPPHEYKFPKNVNWEYKTDTDLYEFAKCKAYP-TSVCFSPDGKKIATIGSDRK 303 Query: 360 IYSF 363 + F Sbjct: 304 VRIF 307 Score = 66.0 bits (159), Expect = 3e-11, Method: Composition-based stats. Identities = 37/237 (15%), Positives = 79/237 (33%), Gaps = 25/237 (10%) Query: 205 HNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRP-TNPHEF 263 H I + T+ +++S D VK W ++ H S +ES ++ Sbjct: 89 HRDVITHVVCTK-TDFIITASHDGHVKFWKKIEEGIEFVKHFRSHLGVIESIAVSSEGAL 147 Query: 264 IVGLSNSKILHYDDRVS---ENQGLVQTYDHHLSSILALKYFPDGSKFISSSED----KT 316 + + K + D V+ N + + I G S + Sbjct: 148 FCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYCP-----GDAISSVAASEKSTGK 202 Query: 317 VRIWENQI-NVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKK 375 + I++ + N P+ + + ++P + I ++ P + PK Sbjct: 203 IFIYDGRGDNQPLHIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFPKN 262 Query: 376 I----------FKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIK 422 + ++ Y S+ FS DG+ I + S ++ + + T +L+ Sbjct: 263 VNWEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIATIGSDRKVRIFRFVTGKLMRVFD 319 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 13/56 (23%), Positives = 25/56 (44%), Gaps = 1/56 (1%) Query: 190 WDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLH 245 W++ D + L +F ++ F+ D + + DR V+I+ TGK+ Sbjct: 265 WEYKTDTD-LYEFAKCKAYPTSVCFSPDGKKIATIGSDRKVRIFRFVTGKLMRVFD 319 >2PM9-A nrPDB Length = 416 Score = 91.0 bits (224), Expect = 9e-19, Method: Composition-based stats. Identities = 51/248 (20%), Positives = 83/248 (33%), Gaps = 19/248 (7%) Query: 155 IRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF------YHDYECLRDFQGHN-- 206 + + H +KF K +++ SGGN+ I IWD +Y L Q + Sbjct: 106 MARFSNHSSSVKTVKFNAKQDNVLASGGNNGEIFIWDMNKCTESPSNYTPLTPGQSMSSV 165 Query: 207 KPIKALRFTED-CQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTP-------ADVESRPT 258 + +L + + F S+ IWD + K L S + VE P Sbjct: 166 DEVISLAWNQSLAHVFASAGSSNFASIWDLKAKKEVIHLSYTSPNSGIKQQLSVVEWHPK 225 Query: 259 NPHEF--IVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKY-FPDGSKFISSSEDK 315 N G N + D + N L H IL+L + D +SS D Sbjct: 226 NSTRVATATGSDNDPSILIWDLRNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSGRDN 285 Query: 316 TVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKK 375 TV +W + + Q + + F S DN+I +L+ ++ Sbjct: 286 TVLLWNPESAEQLSQFPARGNWCFKTKFAPEAPDLFACASFDNKIEVQTLQNLTNTLDEQ 345 Query: 376 IFKGHSSA 383 + Sbjct: 346 ETETKQQE 353 Score = 86.8 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 47/320 (14%), Positives = 107/320 (33%), Gaps = 41/320 (12%) Query: 169 KFLPKTGHLILSG----------GNDHTIKIWDF--YHDYECLRDFQGHNKPIKALRFTE 216 + L++SG D ++++W + + Q +K L ++ Sbjct: 19 AWSHDKIPLLVSGTVSGTVDANFSTDSSLELWSLLAADSEKPIASLQVDSKF-NDLDWSH 77 Query: 217 DCQSFLSSSFDRSVKIWDTETGK----VKTRLHLNSTPA-DVESRPTNPHEFIVGLSNSK 271 + + + + S++++ T R +S+ V+ + G +N + Sbjct: 78 NNKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGE 137 Query: 272 ILHYDDRVSENQGLVQTYD------HHLSSILALKYFPD-GSKFISSSEDKTVRIWENQI 324 I +D T + +++L + F S+ IW+ + Sbjct: 138 IFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKA 197 Query: 325 NVPIKQISDTAQHS-----MPFLNVHP-SQNYFCAQSM---DNRIYSFSLKPKYKRHPKK 375 + +S T+ +S + + HP + + D I + L+ P + Sbjct: 198 KKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNA--NTPLQ 255 Query: 376 IF-KGHSSAGYGISLAF-SGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVD 433 +GH +SL + D + S + + W+ ++ L+ GN + Sbjct: 256 TLNQGHQKG--ILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQFPARGNWC-FKTK 312 Query: 434 WHPQETSKVICSGAAGKIYV 453 + P+ C+ KI V Sbjct: 313 FAPEAPDLFACASFDNKIEV 332 Score = 72.9 bits (177), Expect = 3e-13, Method: Composition-based stats. Identities = 45/274 (16%), Positives = 92/274 (33%), Gaps = 32/274 (11%) Query: 213 RFTEDC-QSFLSS----------SFDRSVKIWDT---ETGKVKTRLHLNSTPADVESRPT 258 ++ D +S S D S+++W ++ K L ++S D++ Sbjct: 19 AWSHDKIPLLVSGTVSGTVDANFSTDSSLELWSLLAADSEKPIASLQVDSKFNDLDWSHN 78 Query: 259 NPHEFIVGLSNSKILHYDDRVSENQ-GLVQTYDHHLSSILALKYFPDGS-KFISSSEDKT 316 N L N + Y + N + + +H SS+ +K+ S + Sbjct: 79 N-KIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGGNNGE 137 Query: 317 VRIWENQ--INVPIKQISDTAQHSMPFLN----VHPSQNY---FCAQSMDNRIYSFSLKP 367 + IW+ P T SM ++ + +Q+ F + N + LK Sbjct: 138 IFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKA 197 Query: 368 KYKRHPKKIFKGHSSAGYGISL-AFSGDGRYICS----GDSKSRLFTWDWNTSRLLNNIK 422 K + +S +S+ + + D+ + WD + Sbjct: 198 KKEVIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNANTPLQTL 257 Query: 423 IPGN-KPITQVDWHPQETSKVICSGAAGKIYVCD 455 G+ K I +DW Q+ ++ SG + + + Sbjct: 258 NQGHQKGILSLDWCHQDEHLLLSSGRDNTVLLWN 291 >5M89-A nrPDB Length = 329 Score = 90.3 bits (222), Expect = 2e-18, Method: Composition-based stats. Identities = 53/340 (15%), Positives = 103/340 (30%), Gaps = 38/340 (11%) Query: 44 IHKRKSHFTKSELKRRRKTRKGDGPWGSWSSSDDETSQASETQKEDQDIFVHALAEDNLD 103 H + + +++R +G W+++DD + + +L +N Sbjct: 12 EHVNEVQQQLMKTRKKRPIPQG------WATADDVAALQQVAYTDLNVTQASSLDLEN-- 63 Query: 104 SEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVD--VDLREERIS----------FRCYLP 151 E V GK + + D+ V E + + Y Sbjct: 64 ----ECAAVGGLDGKLDIYSVVANKVERTLDIGEPVTATEWTGTKVVIGTAKGWVKVYDA 119 Query: 152 KKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKA 211 + + H T L P G ++ S G D + +D R + + + Sbjct: 120 GRESATFQTHAGPVTGLAVHPG-GRILASVGVDKSFVFYDLETGERVARGYA--DAALTT 176 Query: 212 LRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEF-IVGLSNS 270 F D F + + + ++ T T + L TP + N F G S Sbjct: 177 CAFHPDGNLFAAGTQTGHILVFHTTTLEQAESFPL-GTPIQALAFSENGFWFAATGKGTS 235 Query: 271 KILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDK-TVRIWENQINVPIK 329 + +D R S V+ +L++ + G + TV+++ K Sbjct: 236 SVTIFDLRKSGAAAAVKELQ--TGEVLSISWDYTGQYLATGGGTGVTVQMY----TKATK 289 Query: 330 QISDTAQHSMPFLNVHPSQ--NYFCAQSMDNRIYSFSLKP 367 S+ + MP + V S + + K Sbjct: 290 SWSEPVRLGMPVVGVKWGGEAKRLVVVSREGVVSVLGKKE 329 Score = 82.9 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 38/250 (15%), Positives = 87/250 (34%), Gaps = 19/250 (7%) Query: 162 PEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSF 221 E TA ++ TG ++ G +K++D + FQ H P+ L + Sbjct: 92 GEPVTATEW---TGTKVVIGTAKGWVKVYDAGRE---SATFQTHAGPVTGLAVHPGGRIL 145 Query: 222 LSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSE 281 S D+S +D ETG+ R + ++ P + + F G IL + E Sbjct: 146 ASVGVDKSFVFYDLETGERVARGYADAALTTCAFHP-DGNLFAAGTQTGHILVFHTTTLE 204 Query: 282 NQGLVQTYDHHLSSILALKYFPDGSKFISSSE-DKTVRIWENQINVPIKQISDTAQHSMP 340 + I AL + +G F ++ + +V I++ + + + + + Sbjct: 205 QAESFPL----GTPIQALAFSENGFWFAATGKGTSSVTIFDLRKSGAAAAVKELQTGEVL 260 Query: 341 FLNVHPSQNYFCAQSMDN-RIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYIC 399 ++ + Y + ++ K P ++ + + + G+ + + Sbjct: 261 SISWDYTGQYLATGGGTGVTVQMYTKATKSWSEPVRL------GMPVVGVKWGGEAKRLV 314 Query: 400 SGDSKSRLFT 409 + + Sbjct: 315 VVSREGVVSV 324 Score = 61.4 bits (147), Expect = 9e-10, Method: Composition-based stats. Identities = 29/192 (15%), Positives = 67/192 (34%), Gaps = 17/192 (8%) Query: 264 IVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQ 323 VG + K+ Y ++ + + + + A ++ G+K + + V++++ Sbjct: 67 AVGGLDGKLDIYSVVANKVERTLDIGE----PVTATEW--TGTKVVIGTAKGWVKVYDAG 120 Query: 324 INVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSA 383 Q T + L VHP + +D + L+ +++ +G++ A Sbjct: 121 RESATFQ---THAGPVTGLAVHPGGRILASVGVDKSFVFYDLETG-----ERVARGYADA 172 Query: 384 GYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVI 443 + AF DG +G + ++T+ L P PI + + Sbjct: 173 A-LTTCAFHPDGNLFAAGTQTGHILV--FHTTTLEQAESFPLGTPIQALAFSENGFWFAA 229 Query: 444 CSGAAGKIYVCD 455 + + D Sbjct: 230 TGKGTSSVTIFD 241 >3F3P-A nrPDB Length = 351 Score = 86.0 bits (211), Expect = 3e-17, Method: Composition-based stats. Identities = 45/336 (13%), Positives = 99/336 (29%), Gaps = 38/336 (11%) Query: 110 EEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYL----PKKVIRNYPGHPEGT 165 + F + Y + V ++ I ++ ++ H Sbjct: 1 PHMQPFDSGHDDLVHDVVYDFYGRHVATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSI 60 Query: 166 TALKF-LPKTGHLILSGGNDHTIKIWDFYHD--------YECLRDFQGHNKPIKALRFTE 216 A+ + P+ G +I S D T+K+W+ D + L + +++F Sbjct: 61 VAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAP 120 Query: 217 --DCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSN----- 269 D ++++D L S + P N + LS Sbjct: 121 AHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRF 180 Query: 270 ----------SKILHYDDRVSENQGLVQTYDHHLSSILALKYFPD-GSK---FISSSEDK 315 + + Y + H S I ++ + P G + +D Sbjct: 181 SPEKLAVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKDG 240 Query: 316 TVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMD-NRIYSFSLKPKYKRHPK 374 +RI++ + ++ +S F N + D N L+ + Sbjct: 241 RIRIFKITEKLSPLASEESLTNSNMFDN-SADVDMDAQGRSDSNTEEKAELQSNLQVELL 299 Query: 375 KIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTW 410 H+ + S++++ G + S ++ W Sbjct: 300 SEHDDHNGEVW--SVSWNLTGTILSSAGDDGKVRLW 333 Score = 62.9 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 27/186 (14%), Positives = 61/186 (32%), Gaps = 26/186 (13%) Query: 161 HPEGTTALKFLPKT---GHLILSG---------GNDHTIKIWDFYHDYECLRDFQGHNKP 208 H + L + P L +S G D + + GH Sbjct: 166 HLQSDFCLSWCPSRFSPEKLAVSALEQAIIYQRGKDGKLHV---------AAKLPGHKSL 216 Query: 209 IKALRFTE----DCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFI 264 I+++ + Q + D ++I+ + T +++ + Sbjct: 217 IRSISWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDA 276 Query: 265 VGLSNSKIL-HYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQ 323 G S+S + + + L+ +D H + ++ + G+ S+ +D VR+W+ Sbjct: 277 QGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKAT 336 Query: 324 INVPIK 329 + K Sbjct: 337 YSNEFK 342 >2P9P-C nrPDB Length = 372 Score = 86.0 bits (211), Expect = 3e-17, Method: Composition-based stats. Identities = 39/285 (13%), Positives = 89/285 (31%), Gaps = 36/285 (12%) Query: 163 EGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD-YECLRDFQGHNKPIKALRFTEDCQSF 221 E + + I N+H + I++ + + + + + HN + + + D Sbjct: 9 EPISCHAWNKDRTQ-IAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRI 67 Query: 222 LSSSFDRSVKIWDTETGK---VKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDR 278 ++ DR+ +W + L +N V P + S + Y ++ Sbjct: 68 VTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNEKKFAVGSGSRVISICYFEQ 127 Query: 279 VSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHS 338 ++ S++L+L + P+ + S D RI+ I ++ Sbjct: 128 ENDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGSCDFKCRIFSAYIKEVEER-----PAP 182 Query: 339 MPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYI 398 P+ + P F+ SS G+ + FS +G + Sbjct: 183 TPWGSKMPFGELM-------------------------FESSSSCGWVHGVCFSANGSRV 217 Query: 399 CSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVI 443 S + D + ++ P+ V + + + Sbjct: 218 AWVSHDSTVCLADAD-KKMAVATLASETLPLLAVTFITESSLVAA 261 Score = 55.2 bits (131), Expect = 6e-08, Method: Composition-based stats. Identities = 24/155 (15%), Positives = 54/155 (34%), Gaps = 7/155 (4%) Query: 295 SILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQI-SDTAQHSMPFLNVHPSQNYFCA 353 I + D ++ + V I+E N ++ + ++ P N Sbjct: 10 PISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPDSNRIVT 69 Query: 354 QSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGR--YICSGDSKSRLFTWD 411 D Y ++LK + + I + + +A + ++ + + + SG + ++ Sbjct: 70 CGTDRNAYVWTLKGRTWKPTLVILRINRAAR---CVRWAPNEKKFAVGSGSRVISICYFE 126 Query: 412 WNTSRLL-NNIKIPGNKPITQVDWHPQETSKVICS 445 + +IK P + +DWHP S Sbjct: 127 QENDWWVCKHIKKPIRSTVLSLDWHPNSVLLAAGS 161 Score = 43.7 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 28/218 (12%), Positives = 58/218 (26%), Gaps = 59/218 (27%) Query: 165 TTALKFLPKTGHLILSGGNDHTIKIWDFY---HDYECLRDFQGHN--------------K 207 +L + P + L+ +G D +I+ Y + G Sbjct: 145 VLSLDWHPNS-VLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCG 203 Query: 208 PIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGL 267 + + F+ + S D +V + D + L + P + T G Sbjct: 204 WVHGVCFSANGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLAVTFITESSLVAAGH 263 Query: 268 SNSKIL--------------HYDDRVSENQGLVQTYDH---------------------- 291 +L D +Q + + Sbjct: 264 DCFPVLFTYDSAAGKLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGSAAAGAGLDS 323 Query: 292 -HLSSILALKYFPDG----SKFISSSEDKTVRIWENQI 324 H +S+ + G S+F ++ D + IW+ + Sbjct: 324 LHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVRS 361 Score = 33.6 bits (75), Expect = 0.18, Method: Composition-based stats. Identities = 16/77 (20%), Positives = 32/77 (41%), Gaps = 3/77 (3%) Query: 380 HSSAGYGISL-AFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKI-PGNKPITQVDWHPQ 437 HS IS A++ D I + + ++ + ++ + ++ N +T VDW P Sbjct: 4 HSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAPD 63 Query: 438 ETSKVICSGAAGKIYVC 454 +++ G YV Sbjct: 64 SN-RIVTCGTDRNAYVW 79 >1PI6-A nrPDB Length = 615 Score = 85.3 bits (209), Expect = 5e-17, Method: Composition-based stats. Identities = 42/259 (16%), Positives = 89/259 (34%), Gaps = 12/259 (4%) Query: 140 REERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECL 199 R+ F + + GH + A ++ G+D ++ + Sbjct: 138 RDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVFYQGPPFKFSA 197 Query: 200 RDFQGHN--KPIKALRFTED-CQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPAD--VE 254 D H ++ + F+ D + ++ DR + +D ++G+ + + P + Sbjct: 198 SDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIF 257 Query: 255 SRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGS-KFISSSE 313 + + + + D + T D + G+ + IS S Sbjct: 258 ALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSL 317 Query: 314 DKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHP 373 D T+ +E + +K IS + L V+P + S D RI +S ++ H Sbjct: 318 DGTLNFYELGHDEVLKTIS-GHNKGITALTVNP----LISGSYDGRIMEWSSSSMHQDHS 372 Query: 374 KKIFK-GHSSAGYGISLAF 391 I +S A S+++ Sbjct: 373 NLIVSLDNSKAQEYSSISW 391 Score = 83.3 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 46/262 (17%), Positives = 89/262 (33%), Gaps = 24/262 (9%) Query: 156 RNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRD---FQGHNKPIKAL 212 R + ++F P +G +++ G+D I +D + I AL Sbjct: 200 RTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKYIEDDQEPVQGGIFAL 259 Query: 213 RFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPA---DVESRPTNPHEFIVGLSN 269 + D Q F + D ++++WD T K + L+ V T I + Sbjct: 260 SW-LDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVATGNGRIISLSLD 318 Query: 270 SKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIK 329 + Y+ + +++T H I AL P IS S D + W + Sbjct: 319 GTLNFYEL---GHDEVLKTISGHNKGITALTVNP----LISGSYDGRIMEWSSS------ 365 Query: 330 QISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISL 389 + + + L+ +Q Y + S D+ + + K+ ++ G+ L Sbjct: 366 SMHQDHSNLIVSLDNSKAQEYS-SISWDDTLKVNGITKHEFGSQPKVASA-NNDGFTAVL 423 Query: 390 AFSGDGRYI--CSGDSKSRLFT 409 D + +GD + Sbjct: 424 TNDDDLLILQSFTGDIIKSVRL 445 Score = 66.8 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 51/326 (15%), Positives = 99/326 (30%), Gaps = 44/326 (13%) Query: 156 RNYPGHPEGTTALKFLPKTGHLILSGGNDHTIK-IWDFYHDYECLRDFQGH-NKPIKALR 213 RN+ H L + P T + G ++ + D + F GH + + ++ Sbjct: 18 RNFTTH------LSYDPTTNAIAYPCGKSAFVRCLDDGDSKVPPVVQFTGHGSSVVTTVK 71 Query: 214 FTE--DCQSFLSSSFDRSVKIW----DTETG----KVKTRLHLNSTPADVESRPTNPHEF 263 F+ Q S V +W D E+ VK+ + + P S Sbjct: 72 FSPIKGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISWDFEGRRL 131 Query: 264 IV---GLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKF-ISSSEDKTVRI 319 V G N + D + + H I A ++ +D +V Sbjct: 132 CVVGEGRDNFGVFISWDSGNS----LGEVSGHSQRINACHLKQSRPMRSMTVGDDGSVVF 187 Query: 320 WENQINVPIKQISDTAQH-----SMPFLNVHPS-QNYFCAQSMDNRIYSFSLKPKYKRHP 373 + P K + H + + P + D +I F K Sbjct: 188 Y---QGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEFLKY 244 Query: 374 KKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIP----GNKPI 429 + G +L++ D + + + + + WD TS+ + + GN+ + Sbjct: 245 IE-DDQEPVQGGIFALSW-LDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQV 302 Query: 430 TQVDWHPQETSKVICSGAAGKIYVCD 455 V ++I G + + Sbjct: 303 GVVA---TGNGRIISLSLDGTLNFYE 325 Score = 62.5 bits (150), Expect = 4e-10, Method: Composition-based stats. Identities = 49/336 (14%), Positives = 99/336 (29%), Gaps = 58/336 (17%) Query: 118 KSEKDYQGRGYLYPPNDVDVDLR-EERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGH 176 K + Q G + N + L + ++F +V++ GH +G TAL P Sbjct: 294 KQQLGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP---- 349 Query: 177 LILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDT- 235 ++SG D I W Q H+ I +L Q + S S+D ++K+ Sbjct: 350 -LISGSYDGRIMEWSSSS------MHQDHSNLIVSLD-NSKAQEYSSISWDDTLKVNGIT 401 Query: 236 --ETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRV-------SENQGLV 286 E G N+ + + + I S+N V Sbjct: 402 KHEFGSQPKVASANNDGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAV 461 Query: 287 QTYDHHLSSI--------------------LALKYFPDGSKFISSSEDKTVRIWENQINV 326 + + + + P + + + +++ Q Sbjct: 462 GLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSRE 521 Query: 327 PIKQISDTAQHSMPFLNVHPSQN----------YFCAQSMDNRIYSFSLKPKYKRHPKKI 376 + ++ P++ S+D I+ +S+K K K Sbjct: 522 VKTSRWAFRTSKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKRPMKI--IKA 579 Query: 377 FKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDW 412 H + L + + S + + + W+ Sbjct: 580 LNAHKDGVNNL-LWETP--STLVSSGADACIKRWNV 612 >6F1U-h nrPDB Length = 612 Score = 85.3 bits (209), Expect = 5e-17, Method: Composition-based stats. Identities = 66/416 (15%), Positives = 134/416 (32%), Gaps = 53/416 (12%) Query: 76 DDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDV 135 D + T++E Q I D VE DY GR D+ Sbjct: 174 DSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIFFDYSGR-------DL 226 Query: 136 DVDLREERISFRCYLPKKVI-RNYPGHPEGTTALKFLPKTGHLILSGGN----------D 184 + E + + L ++ + H + L + + L++ D Sbjct: 227 EDKEGEIQAGAKLSLNRQFFDERWSKH-RVVSCLDWSSQYPELLV-ASYNNNEDAPHEPD 284 Query: 185 HTIKIWDF-YHDYECLRDFQGHNKPIKALRFTE-DCQSFLSSSFDRSVKIWDTETGK--- 239 +W+ Y F + + F + + ++ + +WD + K Sbjct: 285 GVALVWNMKYKKTTPEYVF-HCQSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTP 343 Query: 240 -----VKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLS 294 + H + N H I ++ KI + + + H S Sbjct: 344 VQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQS 403 Query: 295 ---SILALKYFPDGSK--FISSSEDKTVR-IWENQINVPIKQISDTAQHSMPFLNVHP-- 346 ++ ++ + P G F+ SE+ +V + I ++ + Q + ++ H Sbjct: 404 KAVAVTSMSF-PVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAV 462 Query: 347 ----SQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSG- 401 + F S D + +S K + K ++ +AGY + +S + + Sbjct: 463 GAVDFSHLFVTSSFDWTVKLWSTK-----NNKPLYSFEDNAGYVYDVMWSPTHPALFACV 517 Query: 402 DSKSRLFTWDWNTSRLLNNIKIP--GNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 D RL W+ N + I GN + +V W ++ + G+I + D Sbjct: 518 DGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRW-THSGREIAVGDSEGQIVIYD 572 Score = 69.5 bits (168), Expect = 3e-12, Method: Composition-based stats. Identities = 28/195 (14%), Positives = 68/195 (34%), Gaps = 12/195 (6%) Query: 164 GTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRD---FQGHNKPIKALRFTED--- 217 T++ F + + G + ++ + F+GH PI + Sbjct: 407 AVTSMSFPVGDVNNFVVGSEEGSV--YTACRHGSKAGISEMFEGHQGPITGIHCHAAVGA 464 Query: 218 ---CQSFLSSSFDRSVKIWDTETGKVKTRLHLNST-PADVESRPTNPHEFIVGLSNSKIL 273 F++SSFD +VK+W T+ K N+ DV PT+P F ++ Sbjct: 465 VDFSHLFVTSSFDWTVKLWSTKNNKPLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLD 524 Query: 274 HYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISD 333 ++ ++ +++ G + + + I++ + + + + Sbjct: 525 LWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRNDE 584 Query: 334 TAQHSMPFLNVHPSQ 348 A+ ++ ++ Sbjct: 585 WARFGRTLAEINANR 599 Score = 61.8 bits (148), Expect = 6e-10, Method: Composition-based stats. Identities = 25/130 (19%), Positives = 48/130 (36%), Gaps = 12/130 (9%) Query: 158 YPGHPEGTTALKFLPKTG-----HLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKAL 212 + GH T + G HL ++ D T+K+W ++ + L F+ + + + Sbjct: 446 FEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTKNN-KPLYSFEDNAGYVYDV 504 Query: 213 RFTEDCQSFLSSSFD-RSVKIW----DTETGKVKTRLHLNSTPADVESRPTNPHEFIVGL 267 ++ + + + +W DTE + N V + E VG Sbjct: 505 MWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTH-SGREIAVGD 563 Query: 268 SNSKILHYDD 277 S +I+ YD Sbjct: 564 SEGQIVIYDV 573 Score = 39.4 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 13/101 (12%), Positives = 34/101 (33%), Gaps = 6/101 (5%) Query: 140 REERISFRCYLPK--KVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYE 197 + + + K K + ++ + + + P L + +W+ +D E Sbjct: 474 SSFDWTVKLWSTKNNKPLYSFEDNAGYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTE 533 Query: 198 C---LRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDT 235 +G N + +R+T + + + I+D Sbjct: 534 VPTASISVEG-NPALNRVRWTHSGREIAVGDSEGQIVIYDV 573 >5CXB-B nrPDB Length = 369 Score = 84.1 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 57/370 (15%), Positives = 115/370 (31%), Gaps = 91/370 (24%) Query: 158 YPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTED 217 + GH ++ P TG + +GG+D T+++W+ + ++ + +R+ Sbjct: 17 FRGHEGRVRSVAIDP-TGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNTVRWRPT 75 Query: 218 CQSF---LSSSFDRSVKI------------------------------------------ 232 +F ++ D + I Sbjct: 76 KDTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNGKQQANLPPGKEPPG 135 Query: 233 -W-----DTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLV 286 W E V R+ + ST + H V S + + + Sbjct: 136 KWARPGTRLEDEGVLLRITVRSTIKAISWHRRGDHFATVSPSGQR----------SSVAI 185 Query: 287 QTYDHHLSSI---------LALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQH 337 T HL+ I + P F +++ +++R ++ Q +K + A+ Sbjct: 186 HTLSKHLTQIPFRKLNGLAQTASFHPLRPLFFVATQ-RSIRCYDLQKLELVKIVQPGAK- 243 Query: 338 SMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRY 397 + +VHP + S D R+ L P K + H+ A + F G Sbjct: 244 WISSFDVHPGGDNLVVGSYDKRLLWHDLD--LSNRPYKTMRFHTEAIRAVR--FHKGGLP 299 Query: 398 ICS-GDSKSRLFTWDWNTS------------RLLNNIKIPGNKPITQVDWHPQETSKVIC 444 + + L + ++L K+ + +DWHP+E + Sbjct: 300 LFADASDDGSLQIFHGKVPNDQLENPTIVPVKMLKGHKVVNKLGVLDIDWHPRE-PWCVS 358 Query: 445 SGAAGKIYVC 454 +GA G + Sbjct: 359 AGADGTARLW 368 Score = 80.2 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 42/310 (13%), Positives = 84/310 (27%), Gaps = 70/310 (22%) Query: 201 DFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVK--TRLHLNSTPADVESRPT 258 F+GH ++++ + + D +V++W+ TG+ +L+ + V RPT Sbjct: 16 IFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNTVRWRPT 75 Query: 259 NPHEFIVGLSNSKILHYDDRVSE--------NQGLVQTYDHH------------------ 292 + + I ++ ++ H Sbjct: 76 KDTFILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAGFGHATNGKQQANLPPGKEPPG 135 Query: 293 --------------------LSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQIS 332 S+I A+ + G F + S + +V I +S Sbjct: 136 KWARPGTRLEDEGVLLRITVRSTIKAISWHRRGDHFATVSPSGQ------RSSVAIHTLS 189 Query: 333 DTAQHS--------MPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAG 384 + HP + F + I + L+ + A Sbjct: 190 KHLTQIPFRKLNGLAQTASFHPLRPLFFVATQ-RSIRCYDLQKLELVKIVQP-----GAK 243 Query: 385 YGISLAFSGDGRYICSGDSKSRLFTW-DWNTSRLLNNIKIPGNKPITQVDWHPQETSKVI 443 + S G + G RL W D + S + I V +H Sbjct: 244 WISSFDVHPGGDNLVVGSYDKRL-LWHDLDLSNRPYKTMRFHTEAIRAVRFHKGGLPLFA 302 Query: 444 CSGAAGKIYV 453 + G + + Sbjct: 303 DASDDGSLQI 312 Score = 69.8 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 34/261 (13%), Positives = 76/261 (29%), Gaps = 23/261 (8%) Query: 73 SSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPP 132 +++ + + KE + L+ E + + K+ ++ + Sbjct: 118 ATNGKQQANLPP-GKEPPGKWAR--PGTRLEDEGVLLRITVRSTIKAISWHRRGDHFATV 174 Query: 133 NDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF 192 + + +L + R G + F P + +I+ +D Sbjct: 175 SPSGQRSSVAIHTLSKHLTQIPFRKLNGLAQ---TASFHPLRPLFFV--ATQRSIRCYDL 229 Query: 193 YHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIW---DTETGKVKTRLHLNST 249 E ++ Q K I + + + S+D+ + +W D KT Sbjct: 230 QK-LELVKIVQPGAKWISSFDVHPGGDNLVVGSYDKRL-LWHDLDLSNRPYKTMRFHTEA 287 Query: 250 PADVESRPTNPHEFIVGLSNSKILHY------DDRVSENQGLVQTYDHHLS----SILAL 299 V F + + + D + V+ H +L + Sbjct: 288 IRAVRFHKGGLPLFADASDDGSLQIFHGKVPNDQLENPTIVPVKMLKGHKVVNKLGVLDI 347 Query: 300 KYFPDGSKFISSSEDKTVRIW 320 + P +S+ D T R+W Sbjct: 348 DWHPREPWCVSAGADGTARLW 368 Score = 62.9 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 18/81 (22%), Positives = 39/81 (48%), Gaps = 2/81 (2%) Query: 373 PKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQV 432 + IF+GH S+A G + +G + W+ T R + ++K+ G++ + V Sbjct: 13 QQTIFRGHEGRVR--SVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNTV 70 Query: 433 DWHPQETSKVICSGAAGKIYV 453 W P + + ++ + A I++ Sbjct: 71 RWRPTKDTFILAAAAGEDIFL 91 Score = 56.4 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 13/79 (16%), Positives = 29/79 (36%), Gaps = 3/79 (3%) Query: 287 QTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHP 346 + H + ++ P G + +D TVR+WE + + ++ + P Sbjct: 15 TIFRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNTVRWRP 74 Query: 347 SQNYF---CAQSMDNRIYS 362 +++ F A D + Sbjct: 75 TKDTFILAAAAGEDIFLMI 93 >5WLC-LN nrPDB Length = 776 Score = 81.8 bits (200), Expect = 5e-16, Method: Composition-based stats. Identities = 47/281 (16%), Positives = 86/281 (30%), Gaps = 23/281 (8%) Query: 142 ERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRD 201 R F + P + H K P L + G ++ I+IW+ +++ Sbjct: 34 HRCRFVDFTPATITSLAFSHKSNIN--KLTPSDLRLAI-GRSNGNIEIWNPRNNWFQEMV 90 Query: 202 FQGHNK-PIKALRFTEDCQ---SFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRP 257 +G I+ L ++ S V WD TG NS S Sbjct: 91 IEGGKDRSIEGLCWSNVNGESLRLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISIN 150 Query: 258 TNPHEFIVGLSNSKILHYDDRVSEN-QGLVQTYDHHLSSILALKYFPDGSKFISSSEDKT 316 + + VG N ++ D + +L L + D S D Sbjct: 151 DSQDKLSVGCDNGTVVLIDISGGPGVLEHDTILMRQEARVLTLAWKKDDFVIGGCS-DGR 209 Query: 317 VRIWENQIN-VPIKQISDTAQHS--------MPFLNVHPSQNYFCAQSMDNRIYSFSLKP 367 +RIW Q N + ++ T + + + P + + I + + Sbjct: 210 IRIWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFWDFQF 269 Query: 368 KYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLF 408 + FK H + ++ D Y+ S ++F Sbjct: 270 A---TLNQSFKAHDADVLCLTTD--TDNNYVFSAGVDRKIF 305 Score = 69.5 bits (168), Expect = 3e-12, Method: Composition-based stats. Identities = 42/222 (18%), Positives = 79/222 (35%), Gaps = 26/222 (11%) Query: 165 TTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSS 224 ++ +LP+T I SG + +IK WDF + F+ H+ + L D S+ Sbjct: 241 VWSVIYLPRTDQ-IASGDSTGSIKFWDFQF-ATLNQSFKAHDADVLCLTTDTDNNYVFSA 298 Query: 225 SFDRSVKIWDTETGKVKT---------RLHLNSTPADVESRPTNPHEFIVGLSNSKILHY 275 DR + + T K + RL + + + + +F+V K L Sbjct: 299 GVDRKIFQFSQNTNKSQKNNRWVNSSNRLLHGNDIRAICAYQSKGADFLVSGGVEKTLVI 358 Query: 276 DDRVS---ENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQIS 332 + S N + T + + ++L + +S SE TV+IW + +Q Sbjct: 359 NSLTSFSNGNYRKMPTVEPYSKNVL---VNKEQRLVVSWSE-STVKIWTMGTDSSTEQNY 414 Query: 333 DTAQH-------SMPFLNVHPSQNYFCAQSMDNRIYSFSLKP 367 ++ ++ P + F L+P Sbjct: 415 KLVCKLTLKDDQNISTCSLSPDGQVLVVGRP-STTKVFHLQP 455 Score = 62.9 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 34/232 (14%), Positives = 75/232 (32%), Gaps = 15/232 (6%) Query: 205 HNKPIKALRFTEDCQSFLSSSFDRSVKIWDTET---GKVKTRLHLNSTPADVESRPTNPH 261 H I L T + +++IW+ ++ + + + N Sbjct: 53 HKSNINKL--TPSDLRLAIGRSNGNIEIWNPRNNWFQEMVIEGGKDRSIEGLCWSNVNGE 110 Query: 262 EF-IVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 + + S ++ D + ++ YD + I ++ K ++ TV + Sbjct: 111 SLRLFSIGGSTVVTEWDLATG--LPLRNYDCNSGVIWSISINDSQDKLSVGCDNGTVVLI 168 Query: 321 ENQINVPIKQISDTA-QHSMPFLNVHPSQNYFCAQSM-DNRIYSFSLKPKYKR-----HP 373 + + + + L + ++ F D RI +S + + H Sbjct: 169 DISGGPGVLEHDTILMRQEARVLTLAWKKDDFVIGGCSDGRIRIWSAQKNDENMGRLLHT 228 Query: 374 KKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPG 425 K+ K + S+ + I SGDS + WD+ + L + K Sbjct: 229 MKVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAHD 280 >5A9Q-2 nrPDB Length = 326 Score = 79.9 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 47/272 (17%), Positives = 88/272 (32%), Gaps = 21/272 (7%) Query: 150 LPKKVIRNYPGHPEGTTALKFLPKTG--------HLILSGGNDHTIKIWDFY-HDYECLR 200 + K +R + H + + P+T S D I+++ D + Sbjct: 61 IQYKTLRTFH-HGVRVDGIAWSPETRLDSLPPVIKFCTSAA-DMKIRLFTSDLQDKNEYK 118 Query: 201 DFQGHNKPIKALRFTE-DCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTN 259 +GH I L F + Q S S D + +IW+ E G L+S V P Sbjct: 119 VLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLE-GVQTAHFVLHSPGMSVCWHPEE 177 Query: 260 PHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRI 319 + +V N I YD Q + + + +++ + + + + I Sbjct: 178 TFKLMVAEKNGTIRFYDLLA---QQAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWLI 234 Query: 320 WENQINVPIKQISDTAQHSMPFLNVHP-SQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFK 378 W+ + + S+N F ++ S + + HP+ I Sbjct: 235 WDITRSSYPQNKRPVHMDRACLFRWSTISENLFATTGYPGKMAS-QFQIHHLGHPQPILM 293 Query: 379 GHSSAGYGISLAFSGDGRYICSGDSKSRLFTW 410 G + G L++ G +L W Sbjct: 294 GSVAVG--SGLSWHRTLPLCVIGG-DHKLLFW 322 Score = 69.1 bits (167), Expect = 4e-12, Method: Composition-based stats. Identities = 47/305 (15%), Positives = 90/305 (29%), Gaps = 57/305 (18%) Query: 162 PEGTTALKFLP----KTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTED 217 + ++F P +G+LI GGN++ + C FQ ++ +++ Sbjct: 16 EDYVHVVEFNPFENGDSGNLIAYGGNNYVVI-------GTC--TFQEEEADVEGIQY--- 63 Query: 218 CQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPH-------EFIVGLSNS 270 K H + P +F ++ Sbjct: 64 ---------------------KTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADM 102 Query: 271 KILHY-DDRVSENQGLVQTYDHHLSSILALKYFP-DGSKFISSSEDKTVRIWENQINVPI 328 KI + D +N+ V + H I L + P +G + S S+D T RIW + Sbjct: 103 KIRLFTSDLQDKNEYKV--LEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTA 160 Query: 329 KQISDTAQHSMPFLNVHPSQNY-FCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGI 387 + + + HP + + + I + L + I S + Sbjct: 161 HFVLHSPG---MSVCWHPEETFKLMVAEKNGTIRFYDL-----LAQQAILSLESEQVPLM 212 Query: 388 SLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGA 447 S + + + + WD S N + W + +G Sbjct: 213 SAHWCLKNTFKVGAVAGNDWLIWDITRSSYPQNKRPVHMDRACLFRWSTISENLFATTGY 272 Query: 448 AGKIY 452 GK+ Sbjct: 273 PGKMA 277 Score = 57.1 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 26/144 (18%), Positives = 49/144 (34%), Gaps = 15/144 (10%) Query: 321 ENQINVPIKQISDTAQHSMPFLNVHPSQNY--------FCAQSMDNRIYSFSLKPKYKRH 372 + + + + + P FC + D +I F+ ++ Sbjct: 57 DVEGIQYKTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFT-SDLQDKN 115 Query: 373 PKKIFKGHSSAGYGISLAFSG-DGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQ 431 K+ +GH+ + L F +G+ I S W+ + + P Sbjct: 116 EYKVLEGHTD--FINGLVFDPKEGQEIASVSDDHTCRIWNLEG---VQTAHFVLHSPGMS 170 Query: 432 VDWHPQETSKVICSGAAGKIYVCD 455 V WHP+ET K++ + G I D Sbjct: 171 VCWHPEETFKLMVAEKNGTIRFYD 194 >4J0X-A nrPDB Length = 451 Score = 78.7 bits (192), Expect = 5e-15, Method: Composition-based stats. Identities = 28/218 (12%), Positives = 59/218 (27%), Gaps = 19/218 (8%) Query: 201 DFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPT-- 258 +GH I + + D + ++ DR + +W TE+ + +V S Sbjct: 109 TTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRK 168 Query: 259 NPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVR 318 N + ++ KI Y + H + + + D+T Sbjct: 169 NSDQLYASCADFKIRTYSINQFSQLEI---LYGHHDIVEDISALAMERCVTVGARDRTAM 225 Query: 319 IWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFK 378 +W +P + P + + D + P P + Sbjct: 226 LW----KIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVK----YPDESEAPLFFCE 277 Query: 379 GHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSR 416 G + D + +G + W + Sbjct: 278 GSIDVVSMV------DDFHFITGSDNGNICLWSLAKKK 309 Score = 77.9 bits (190), Expect = 9e-15, Method: Composition-based stats. Identities = 51/351 (14%), Positives = 105/351 (29%), Gaps = 53/351 (15%) Query: 124 QGRGYLYPPNDVDVDLREERISFRCYLPKKV-----------------IRNYPGHPEGTT 166 +GR + Y + D+ L + I+ PKK+ GH + Sbjct: 60 KGRLFAYTVSK-DLQLTKYDITDFSKRPKKLKYAKGGAKYIPTSKHEYENTTEGHYDEIL 118 Query: 167 ALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDF--QGHNKPIKALRFTEDCQSFLSS 224 + P G +++GG D + +W ++ + + +L F ++ +S Sbjct: 119 TVAASPD-GKYVVTGGRDRKLIVWS-TESLSPVKVIPTKDRRGEVLSLAFRKNSDQLYAS 176 Query: 225 SFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQG 284 D ++ + L+ + + S VG + + + Sbjct: 177 CADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGARDRTAMLWKIPDETRL- 235 Query: 285 LVQTYDHHLSSILAL-KYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLN 343 T+ L ++ + +K ED V+ + + P+ + + Sbjct: 236 ---TFRGGDEPQKLLRRWMKENAK---EGEDGEVKYPD-ESEAPLFFCEGSIDVVSMVDD 288 Query: 344 VHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDS 403 H F S + I +SL K ++I G + SG++ Sbjct: 289 FH-----FITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDI----------SGET 333 Query: 404 KSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVC 454 L +LL I I ++ I +G + V Sbjct: 334 DEELRKRQLQGKKLLQPFWITSLYAI-------PYSNVFISGSWSGSLKVW 377 Score = 47.9 bits (112), Expect = 8e-06, Method: Composition-based stats. Identities = 47/349 (13%), Positives = 90/349 (25%), Gaps = 90/349 (25%) Query: 61 KTRKGDGPWGSWSSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSE 120 ++ GD G + + T+ + D + H Y + Sbjct: 52 ESSNGDKNKGRLFAY-TVSKDLQLTKYDITDFSKRPKKLKYAKGGAKYIPTSKHEYENTT 110 Query: 121 KDY----------QGRGYLYPPNDVDVDLREERI--SFRCYLPKKVIRNYPGHPEGTTAL 168 + + Y+ V + I S P KVI +L Sbjct: 111 EGHYDEILTVAASPDGKYV-----VTGGRDRKLIVWSTESLSPVKVIPT-KDRRGEVLSL 164 Query: 169 KFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDR 228 F + L S D I+ + + L GH+ ++ + + + DR Sbjct: 165 AFRKNSDQLYASCA-DFKIRTYSINQ-FSQLEILYGHHDIVEDISALAMERCVTVGARDR 222 Query: 229 SVKIWDTETGKVKTRLHLNST-----------------------------------PADV 253 + +W T + DV Sbjct: 223 TAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDV 282 Query: 254 ESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHH--------------------- 292 S + H FI G N I + +++ + + H Sbjct: 283 VSMVDDFH-FITGSDNGNICLW--SLAKKKPIFTERIAHGILPEPSFNDISGETDEELRK 339 Query: 293 ----------LSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQI 331 I +L P + FIS S ++++W+ N+ ++ Sbjct: 340 RQLQGKKLLQPFWITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFEL 388 Score = 37.1 bits (84), Expect = 0.014, Method: Composition-based stats. Identities = 17/90 (18%), Positives = 40/90 (44%), Gaps = 10/90 (11%) Query: 133 NDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF 192 ND+ +E + R KK+++ + T+L +P + ++ +SG ++K+W Sbjct: 327 NDIS-GETDEELRKRQLQGKKLLQPF-----WITSLYAIPYS-NVFISGSWSGSLKVWKI 379 Query: 193 YHD---YECLRDFQGHNKPIKALRFTEDCQ 219 + +E L + G + ++ E + Sbjct: 380 SDNLRSFELLGELSGAKGVVTKIQVVESGK 409 >5WLC-SG nrPDB Length = 573 Score = 77.5 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 28/218 (12%), Positives = 59/218 (27%), Gaps = 19/218 (8%) Query: 201 DFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPT-- 258 +GH I + + D + ++ DR + +W TE+ + +V S Sbjct: 231 TTEGHYDEILTVAASPDGKYVVTGGRDRKLIVWSTESLSPVKVIPTKDRRGEVLSLAFRK 290 Query: 259 NPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVR 318 N + ++ KI Y + H + + + D+T Sbjct: 291 NSDQLYASCADFKIRTYSINQFSQLEI---LYGHHDIVEDISALAMERCVTVGARDRTAM 347 Query: 319 IWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFK 378 +W +P + P + + D + P P + Sbjct: 348 LW----KIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVK----YPDESEAPLFFCE 399 Query: 379 GHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSR 416 G + D + +G + W + Sbjct: 400 GSIDVVSMV------DDFHFITGSDNGNICLWSLAKKK 431 Score = 76.0 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 51/351 (14%), Positives = 105/351 (29%), Gaps = 53/351 (15%) Query: 124 QGRGYLYPPNDVDVDLREERISFRCYLPKKV-----------------IRNYPGHPEGTT 166 +GR + Y + D+ L + I+ PKK+ GH + Sbjct: 182 KGRLFAYTVSK-DLQLTKYDITDFSKRPKKLKYAKGGAKYIPTSKHEYENTTEGHYDEIL 240 Query: 167 ALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDF--QGHNKPIKALRFTEDCQSFLSS 224 + P G +++GG D + +W ++ + + +L F ++ +S Sbjct: 241 TVAASPD-GKYVVTGGRDRKLIVWS-TESLSPVKVIPTKDRRGEVLSLAFRKNSDQLYAS 298 Query: 225 SFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQG 284 D ++ + L+ + + S VG + + + Sbjct: 299 CADFKIRTYSINQFSQLEILYGHHDIVEDISALAMERCVTVGARDRTAMLWKIPDETRL- 357 Query: 285 LVQTYDHHLSSILAL-KYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLN 343 T+ L ++ + +K ED V+ + + P+ + + Sbjct: 358 ---TFRGGDEPQKLLRRWMKENAK---EGEDGEVKYPD-ESEAPLFFCEGSIDVVSMVDD 410 Query: 344 VHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDS 403 H F S + I +SL K ++I G + SG++ Sbjct: 411 FH-----FITGSDNGNICLWSLAKKKPIFTERIAHGILPEPSFNDI----------SGET 455 Query: 404 KSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVC 454 L +LL I I ++ I +G + V Sbjct: 456 DEELRKRQLQGKKLLQPFWITSLYAI-------PYSNVFISGSWSGSLKVW 499 Score = 46.3 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 47/349 (13%), Positives = 90/349 (25%), Gaps = 90/349 (25%) Query: 61 KTRKGDGPWGSWSSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSE 120 ++ GD G + + T+ + D + H Y + Sbjct: 174 ESSNGDKNKGRLFAY-TVSKDLQLTKYDITDFSKRPKKLKYAKGGAKYIPTSKHEYENTT 232 Query: 121 KDY----------QGRGYLYPPNDVDVDLREERI--SFRCYLPKKVIRNYPGHPEGTTAL 168 + + Y+ V + I S P KVI +L Sbjct: 233 EGHYDEILTVAASPDGKYV-----VTGGRDRKLIVWSTESLSPVKVIPT-KDRRGEVLSL 286 Query: 169 KFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDR 228 F + L S D I+ + + L GH+ ++ + + + DR Sbjct: 287 AFRKNSDQLYASCA-DFKIRTYSINQ-FSQLEILYGHHDIVEDISALAMERCVTVGARDR 344 Query: 229 SVKIWDTETGKVKTRLHLNST-----------------------------------PADV 253 + +W T + DV Sbjct: 345 TAMLWKIPDETRLTFRGGDEPQKLLRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDV 404 Query: 254 ESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHH--------------------- 292 S + H FI G N I + +++ + + H Sbjct: 405 VSMVDDFH-FITGSDNGNICLW--SLAKKKPIFTERIAHGILPEPSFNDISGETDEELRK 461 Query: 293 ----------LSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQI 331 I +L P + FIS S ++++W+ N+ ++ Sbjct: 462 RQLQGKKLLQPFWITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFEL 510 Score = 36.7 bits (83), Expect = 0.021, Method: Composition-based stats. Identities = 17/90 (18%), Positives = 40/90 (44%), Gaps = 10/90 (11%) Query: 133 NDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF 192 ND+ +E + R KK+++ + T+L +P + ++ +SG ++K+W Sbjct: 449 NDIS-GETDEELRKRQLQGKKLLQPF-----WITSLYAIPYS-NVFISGSWSGSLKVWKI 501 Query: 193 YHD---YECLRDFQGHNKPIKALRFTEDCQ 219 + +E L + G + ++ E + Sbjct: 502 SDNLRSFELLGELSGAKGVVTKIQVVESGK 531 >5A9Q-0 nrPDB Length = 380 Score = 77.2 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 35/316 (11%), Positives = 96/316 (30%), Gaps = 57/316 (18%) Query: 162 PEGTTALKFLP------KTGHLILSGGNDHT---IKIWDF------------YHDYECLR 200 + + ++ P +T +G D+ I +W D++ L Sbjct: 10 SQKISKTRWRPLPPGSLQTAETFATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLC 69 Query: 201 DFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNP 260 D + H + L+F + + +SS TG V LH + ++ Sbjct: 70 DIRHH-GDVMDLQFFDQERIVAASS-----------TGCVTVFLHHPNNQTLSVNQQWTT 117 Query: 261 HEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIW 320 + G + + + ++ + + ++ ED + ++ Sbjct: 118 AHYHTGPGS--------PSYSSAPC--------TGVVC-----NNPEIVTVGEDGRINLF 156 Query: 321 ENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGH 380 ++ I + ++ + + S+ ++ + + + P +I Sbjct: 157 RADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSI-GQLKIWDFR-QQGNEPSQILSLT 214 Query: 381 SSAGYGISLAFSGDGRYICS-GDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQET 439 + + +++ + G L WD + ++ + +V +HP Sbjct: 215 GDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVHFHPSNP 274 Query: 440 SKVICSGAAGKIYVCD 455 + G ++ D Sbjct: 275 EHLFTCSEDGSLWHWD 290 Score = 67.1 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 31/175 (17%), Positives = 60/175 (34%), Gaps = 10/175 (5%) Query: 178 ILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTET 237 I++ G D I ++ H + + A+ F + L+ + +KIWD Sbjct: 144 IVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPE-ILTVNSIGQLKIWDFRQ 202 Query: 238 -----GKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHH 292 ++ + V+ P H G + + +D R V H Sbjct: 203 QGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGT--MPVSLLKAH 260 Query: 293 LSSILALKYFPDG-SKFISSSEDKTVRIWENQINVPIK-QISDTAQHSMPFLNVH 345 + + + + P + SED ++ W+ +VP K + S FL+ Sbjct: 261 EAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQGGRSSTFLSHS 315 Score = 63.3 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 27/193 (13%), Positives = 56/193 (29%), Gaps = 17/193 (8%) Query: 129 LYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIK 188 + N + L+ + P +++ + G + P H++ +GG D + Sbjct: 186 ILTVNSIG-QLKIWDFRQQGNEPSQIL-SLTGDRVPLHCVDRHPNQQHVVATGGQDGMLS 243 Query: 189 IWDFYHDYECLRDFQGHNKPIKALRFTEDC-QSFLSSSFDRSVKIWDTETGKVKTRLHLN 247 IWD + + H + + F + + S D S+ WD T + + Sbjct: 244 IWDVRQGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFH 303 Query: 248 STPADVESRP------TNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKY 301 N H+ ++ S D + + S+ L Sbjct: 304 QGGRSSTFLSHSISNQANVHQSVISSWLST-----DPAKDRIEITSLLPSRSLSVNTLDV 358 Query: 302 FPDGSKFISSSED 314 + D Sbjct: 359 L---GPCLVCGTD 368 >5A9Q-7 nrPDB Length = 360 Score = 76.0 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 27/223 (12%), Positives = 62/223 (27%), Gaps = 29/223 (13%) Query: 247 NSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKY-FPD- 304 + S + S+ + +D S + ++ H S+ + + P+ Sbjct: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70 Query: 305 GSKFISSSEDKTVRIWENQINVP-----------IKQISDTAQHSMPFLNVHPS--QNYF 351 G S S D+T +WE + + ++ S+ + P Sbjct: 71 GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLML 130 Query: 352 CAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGR-----YICSGDSKSR 406 S D + + + S ++++ I G S Sbjct: 131 ATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSS 190 Query: 407 --------LFTWDWNTSRLLN-NIKIPGNKPITQVDWHPQETS 440 +F ++ NT + + P+ + + P Sbjct: 191 PNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGR 233 Score = 68.7 bits (166), Expect = 5e-12, Method: Composition-based stats. Identities = 46/297 (15%), Positives = 95/297 (31%), Gaps = 49/297 (16%) Query: 205 HNKPIKALRFTEDCQSFLSSSFDRSVKIWD-TETGKVKTRLHLNSTPADV----ESRPTN 259 H I + F + + S D+SVK+WD +E+G + V + P Sbjct: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70 Query: 260 PHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHL---------SSILALKYFPD--GSKF 308 + +++ V E+ ++ H + +S+ +K+ P G Sbjct: 71 GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLML 130 Query: 309 ISSSEDKTVRIWENQINVPIKQISDTAQ--HSMPFLNVHPS-------QNYFCAQSMDN- 358 + S D VRI+E + + Q S + + + + S D+ Sbjct: 131 ATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSS 190 Query: 359 -----RIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDG----RYICSGDSKSRLF- 408 ++ F + R K + +AF+ + + R+F Sbjct: 191 PNAMAKVQIFE-YNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFT 249 Query: 409 ----TWDWNTSRLLNNIKIP-------GNKPITQVDWHPQETSKVICSGAAGKIYVC 454 + +S +I N + +V W+ + + SG G + + Sbjct: 250 LKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNIT-GTVLASSGDDGCVRLW 305 Score = 67.9 bits (164), Expect = 9e-12, Method: Composition-based stats. Identities = 34/290 (11%), Positives = 77/290 (26%), Gaps = 62/290 (21%) Query: 152 KKVIRNYPGHPEGTTALKF-LPKTGHLILSGGNDHTIKIWD-----------FYHDYECL 199 ++ H + + P+ G ++ S D T +W+ + Sbjct: 47 WHCTASWKTHSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKR 106 Query: 200 RDFQGHNKPIKALRFTED--CQSFLSSSFDRSVKIW---DTETGKVKTRLHLNSTPADVE 254 + ++F + S D V+I+ D + H S Sbjct: 107 TTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCS 166 Query: 255 SRPTNPHE-------FIVGLSNS------KILHYD-DRVSENQGLVQTYDHHLSSILALK 300 NP VG +S K+ ++ + + +T + + Sbjct: 167 CISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIA 226 Query: 301 YFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRI 360 + P+ + I A + + P + + Sbjct: 227 FAPNLGR--------------------SFHILAIATKDVRIFTLKPVRKELTSSGGP--- 263 Query: 361 YSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTW 410 K++ H F H+S + ++++ G + S + W Sbjct: 264 ------TKFEIHIVAQFDNHNSQVW--RVSWNITGTVLASSGDDGCVRLW 305 Score = 64.5 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 31/192 (16%), Positives = 66/192 (34%), Gaps = 34/192 (17%) Query: 164 GTTALKFLPK-TGHLILSGGNDHTIKIWDFYHDYECLRDFQGH----NKPIKALRFTE-- 216 T +KF PK G ++ + D ++I++ + H + + Sbjct: 115 SVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSS 174 Query: 217 ---DCQSFLSSSFDRS------VKIWDTETG-----KVKTRLHLNSTPADVESRPTNPHE 262 S D S V+I++ K +T + + D+ P Sbjct: 175 SRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRS 234 Query: 263 F-IVGLSNSKILHYDDRVSENQ------------GLVQTYDHHLSSILALKYFPDGSKFI 309 F I+ ++ + + + + +V +D+H S + + + G+ Sbjct: 235 FHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLA 294 Query: 310 SSSEDKTVRIWE 321 SS +D VR+W+ Sbjct: 295 SSGDDGCVRLWK 306 Score = 38.6 bits (88), Expect = 0.006, Method: Composition-based stats. Identities = 17/165 (10%), Positives = 47/165 (28%), Gaps = 34/165 (20%) Query: 166 TALKFLPKTG----HLILSGGNDH------TIKIWDFYHDYECLR---DFQGHNKPIKAL 212 + + + P + +I G +D ++I+++ + P+ + Sbjct: 166 SCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDI 225 Query: 213 RFTEDC----QSFLSSSFDRSVKIWDTE---------TGKVKTRLH----LNSTPADVES 255 F + ++ D V+I+ + G K +H ++ + V Sbjct: 226 AFAPNLGRSFHILAIATKD--VRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWR 283 Query: 256 RPTN--PHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILA 298 N + + + +N + S + Sbjct: 284 VSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPVNG 328 >3EI3-B nrPDB Length = 383 Score = 75.6 bits (184), Expect = 4e-14, Method: Composition-based stats. Identities = 48/329 (14%), Positives = 105/329 (31%), Gaps = 33/329 (10%) Query: 153 KVIRNYPGHP------EGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDF---Q 203 + +++Y H T+L++ P + G I +WD+ D + F Sbjct: 58 RSLKSYKLHRTASPFDRRVTSLEWHPTHPTTVAVGSKGGDIILWDY--DVQNKTSFIQGM 115 Query: 204 GHNKPIKALRFTE-DCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHE 262 G I ++F + + SS + + D ++ +S + Sbjct: 116 GPGDAITGMKFNQFNTNQLFVSSIRGATTLRDFSGSVIQVFAKTDSWDYWYCCVDVSVSR 175 Query: 263 FIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSK-FISSSEDKTVRIWE 321 ++ +S + ++ + H + + ++ P +SS D TV++W+ Sbjct: 176 QMLATGDSTGRLLLLGLDGHEIFKEKL--HKAKVTHAEFNPRCDWLMATSSVDATVKLWD 233 Query: 322 NQINVPIKQISDTAQH--SMPFLNVHP-SQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFK 378 + H + +P N I +S K I Sbjct: 234 LRNIKDKNSYIAEMPHEKPVNAAYFNPTDSTKLLTTDQRNEIRVYSSYDWSKPDQIIIHP 293 Query: 379 GHSSAGYGISL--AFSGDGRYICSG---------DSKSRLFTWDWNTSRLLNNIKIPGNK 427 H + + + I +G + K + +D N+ L++ ++ P Sbjct: 294 -HRQFQHLTPIKATWHPMYDLIVAGRYPDDQLLLNDKRTIDIYDANSGGLVHQLRDPNAA 352 Query: 428 PITQV-DWHPQETSKVICSGAAGKIYVCD 455 I + + P V+ SG I + + Sbjct: 353 GIISLNKFSPTGD--VLASGMGFNILIWN 379 >5WLC-LW nrPDB Length = 554 Score = 74.5 bits (181), Expect = 1e-13, Method: Composition-based stats. Identities = 53/399 (13%), Positives = 126/399 (31%), Gaps = 47/399 (11%) Query: 21 KSVHEKKNGNLHEDTSYEPSSNNIHKRKSHFTKSELKRRRKTRKGDGPWGSWSSSDDETS 80 + + E++N N +E S+ + + +H + K R +K D + SS T Sbjct: 10 RQIKERENQN-----KFERSTYTNNAKNNHTQTKDKKLRAGLKKIDEQYKKAVSSAAATD 64 Query: 81 QASET-------QKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDY-----QGRGY 128 + E + F +E + + K Y + + Sbjct: 65 YLLPESNGYLEPENELEKTFKVQQSEIKSSVDVSTANKALDLSLKEFGPYHIKYAKNGTH 124 Query: 129 LYPP-NDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTI 187 L V + R + L ++ N H + +T Sbjct: 125 LLITGRKGHVASMDWR---KGQLRAELFLNETCHSATYL------QNEQYFAVAQKKYT- 174 Query: 188 KIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLN 247 I+D H+ L + H + + L F +++ +K D TG++ + L Sbjct: 175 FIYD--HEGTELHRLKQHIEA-RHLDFLPYHYLLVTAGETGWLKYHDVSTGQLVSELRTK 231 Query: 248 STPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSK 307 + P ++ +G SN + + + E + + + ++ G Sbjct: 232 AGPTMAMAQNPWNAVMHLGHSNGTVSLWSPSMPEPLVKLLSARG---PVNSIAIDRSGYY 288 Query: 308 FISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKP 367 ++ D++++IW+ + + + +++ + ++ ++ +LK Sbjct: 289 MATTGADRSMKIWDIRNFKQLHSVESLPTPGTN-VSISDTGLLALSRGPHVTLWKDALKL 347 Query: 368 KYKRHPKKIFKG---HSSAGYGISLAFSGDGRYICSGDS 403 P G H + Y ++ +G+ Sbjct: 348 SGDSKPCFGSMGGNPHRNTPYM---------SHLFAGNK 377 Score = 53.3 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 34/212 (16%), Positives = 74/212 (34%), Gaps = 15/212 (7%) Query: 212 LRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSK 271 +++ ++ L + V D G+++ L LN T + N F V Sbjct: 116 IKYAKNGTHLLITGRKGHVASMDWRKGQLRAELFLNET-CHSATYLQNEQYFAVA-QKKY 173 Query: 272 ILHYDDRVSENQGLVQTYDH-HLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQ 330 YD +E L Q + H L + P +++ E ++ + + + Sbjct: 174 TFIYDHEGTELHRLKQHIEARH------LDFLPYHYLLVTAGETGWLKYHDVSTGQLVSE 227 Query: 331 ISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLA 390 + A + +P + + +S P+ + K S+ G S+A Sbjct: 228 LRTKAG-PTMAMAQNPWNAVMHLGHSNGTVSLWS-----PSMPEPLVKLLSARGPVNSIA 281 Query: 391 FSGDGRYICSGDSKSRLFTWDWNTSRLLNNIK 422 G Y+ + + + WD + L++++ Sbjct: 282 IDRSGYYMATTGADRSMKIWDIRNFKQLHSVE 313 Score = 38.6 bits (88), Expect = 0.006, Method: Composition-based stats. Identities = 28/223 (12%), Positives = 60/223 (26%), Gaps = 17/223 (7%) Query: 234 DTETGKVKTRLHL-NSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHH 292 D T L L P ++ H I G + L H Sbjct: 96 DVSTANKALDLSLKEFGPYHIKYAKNGTHLLITGRKGHVASMDWRKGQLRAELFLNETCH 155 Query: 293 LSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFC 352 + Y + F + + K I++++ + + FL H Sbjct: 156 -----SATYLQNEQYFAVAQK-KYTFIYDHEGTELHRLKQHIEARHLDFLPYH---YLLV 206 Query: 353 AQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDW 412 + + + AG +++A + + G S + W Sbjct: 207 TAGETGWLKYHDVSTGQLVSELRT-----KAGPTMAMAQNPWNAVMHLGHSNGTVSLWSP 261 Query: 413 NTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 + L + + P+ + + + +GA + + D Sbjct: 262 SMPEPLVKL-LSARGPVNSIAID-RSGYYMATTGADRSMKIWD 302 >3DWL-C nrPDB Length = 377 Score = 73.3 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 35/242 (14%), Positives = 81/242 (33%), Gaps = 26/242 (10%) Query: 185 HTIKIWDFY-HDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIW----DTETGK 239 + +++++ + ++ R F H+K + + + ++ S DR+ ++ D + Sbjct: 33 NQVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSNRIVTCSQDRNAYVYEKRPDGTWKQ 92 Query: 240 VKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHH-LSSILA 298 L LN V P N +F VG I + + + S+IL+ Sbjct: 93 TLVLLRLNRAATFVRWSP-NEDKFAVGSGARVISVCYFEQENDWWVSKHLKRPLRSTILS 151 Query: 299 LKYFPDGSKFISSSEDKTVR----------------IWENQINVPIKQISDTAQHSMPFL 342 L + P+ + D+ +W +++ + + + Sbjct: 152 LDWHPNNVLLAAGCADRKAYVLSAYVRDVDAKPEASVWGSRLPFNTVCAEYPSGGWVHAV 211 Query: 343 NVHPSQNYFCAQSMDNRIYS-FSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSG 401 PS N D+ + + P+ K S SL ++ + + +G Sbjct: 212 GFSPSGNALAYAGHDSSVTIAYPSAPEQPPRALITVK--LSQLPLRSLLWANESAIVAAG 269 Query: 402 DS 403 + Sbjct: 270 YN 271 Score = 59.8 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 24/172 (13%), Positives = 66/172 (38%), Gaps = 4/172 (2%) Query: 240 VKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILAL 299 LH+ P+ + + EF+ + +++ Y ++ +T+ H + + Sbjct: 3 TSQVLHILPKPSYEHAFNSQRTEFVTTTATNQVELY-EQDGNGWKHARTFSDHDKIVTCV 61 Query: 300 KYFPDGSKFISSSEDKTVRIWENQINVPIKQ--ISDTAQHSMPFLNVHPSQNYFCAQSMD 357 + P ++ ++ S+D+ ++E + + KQ + + F+ P+++ F S Sbjct: 62 DWAPKSNRIVTCSQDRNAYVYEKRPDGTWKQTLVLLRLNRAATFVRWSPNEDKFAVGSGA 121 Query: 358 NRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFT 409 I + + K K +SL + + + +G + + + Sbjct: 122 RVISVCYFEQENDWWVSKHLK-RPLRSTILSLDWHPNNVLLAAGCADRKAYV 172 Score = 50.2 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 21/152 (13%), Positives = 49/152 (32%), Gaps = 2/152 (1%) Query: 300 KYFPDGSKFISSSEDKTVRIWENQINVPIK-QISDTAQHSMPFLNVHPSQNYFCAQSMDN 358 + ++F++++ V ++E N + + ++ P N S D Sbjct: 18 AFNSQRTEFVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSNRIVTCSQDR 77 Query: 359 RIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLL 418 Y + +P + + A + + + D + SG + ++ + Sbjct: 78 NAYVYEKRPDGTWKQTLVLLRLNRAATFVRWSPNEDKFAVGSGARVISVCYFEQENDWWV 137 Query: 419 -NNIKIPGNKPITQVDWHPQETSKVICSGAAG 449 ++K P I +DWHP Sbjct: 138 SKHLKRPLRSTILSLDWHPNNVLLAAGCADRK 169 Score = 32.1 bits (71), Expect = 0.58, Method: Composition-based stats. Identities = 28/178 (15%), Positives = 58/178 (32%), Gaps = 26/178 (14%) Query: 162 PEGTTALKFLPKTGHLILSGGNDHTIKI-WDFYHDYEC--LRDFQGHNKPIKALRFTEDC 218 A+ F P +G+ + G+D ++ I + + L + P+++L + + Sbjct: 205 GGWVHAVGFSP-SGNALAYAGHDSSVTIAYPSAPEQPPRALITVKLSQLPLRSLLWANES 263 Query: 219 QSFLSSSFDRSVKI------W----DTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLS 268 + + + W D + G KT + + Sbjct: 264 AIVAAGYNYSPILLQGNESGWAHTRDLDAGTSKTSF---THTGNTGEGREEEGPVSFTAL 320 Query: 269 NSKILHYDDRVSENQGLVQTYDHHLSSILALKYFP------DGSKFISSSEDKTVRIW 320 S + D + +Q + H + I L+ P + + F SS D V +W Sbjct: 321 RSTFRNMDLK-GSSQSISSLPTVHQNMIATLR--PYAGTPGNITAFTSSGTDGRVVLW 375 >5K19-A nrPDB Length = 569 Score = 72.5 bits (176), Expect = 4e-13, Method: Composition-based stats. Identities = 35/202 (17%), Positives = 66/202 (32%), Gaps = 26/202 (12%) Query: 241 KTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALK 300 + RL S V+ P + F+V S+ + Y+ + T H Sbjct: 143 EERLIDKSRVTCVKWVPGSESLFLVAHSSGNMYLYNVEHT-----CGTTAPHYQ------ 191 Query: 301 YFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRI 360 G F T + + + + + A + P + S D + Sbjct: 192 LLKQGESFAV----HTCKSKSTRNPLLKWTVGEGA---LNEFAFSPDGKFLACVSQDGFL 244 Query: 361 YSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNN 420 F+ K + G + + +S DG+YI +G + W + R++ Sbjct: 245 RVFNFDSVELHGTMKSYFGG-----LLCVCWSPDGKYIVTGGEDDLVTVWSFVDCRVIAR 299 Query: 421 IKIPGNKP-ITQVDWHPQETSK 441 G+K ++ V + P TS Sbjct: 300 --GHGHKSWVSVVAFDPYTTSV 319 Score = 65.2 bits (157), Expect = 5e-11, Method: Composition-based stats. Identities = 30/263 (11%), Positives = 82/263 (31%), Gaps = 45/263 (17%) Query: 165 TTALKFLPKTGHLILSGGNDHTIKIWDFYH-------DYECLR---DFQGHN-------- 206 T +K++P + L L + + +++ H Y+ L+ F H Sbjct: 152 VTCVKWVPGSESLFLVAHSSGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKSTRN 211 Query: 207 ---------KPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRP 257 + F+ D + S D +++++ ++ ++ + Sbjct: 212 PLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWS 271 Query: 258 TNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFP------DGSKFISS 311 + + G + + + + ++ H S + + + P +G S Sbjct: 272 PDGKYIVTGGEDDLVTVW---SFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPMEFS 328 Query: 312 SEDK----TVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKP 367 D+ + ++ N ++S ++V F + D ++ + L Sbjct: 329 GSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYR---FGSVGQDTQLCLWDLTE 385 Query: 368 K--YKRHPKKIFKGHSSAGYGIS 388 + P + H++ S Sbjct: 386 DILFPHQPLSRARTHTNVMNATS 408 Score = 52.9 bits (125), Expect = 3e-07, Method: Composition-based stats. Identities = 30/217 (13%), Positives = 66/217 (30%), Gaps = 49/217 (22%) Query: 118 KSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHL 177 +L ++ + + ++ + G + + P G Sbjct: 224 NEFAFSPDGKFLACV------SQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPD-GKY 276 Query: 178 ILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTET 237 I++GG D + +W F D + GH + + F ++S E Sbjct: 277 IVTGGEDDLVTVWSFV-DCRVIARGHGHKSWVSVVAFDP-----YTTS---------VEE 321 Query: 238 GKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYD--DRVSENQGLVQTYDHHLSS 295 G +P EF + + L + DR + Q + + S Sbjct: 322 G--------------------DPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSR 361 Query: 296 ILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQIS 332 +++ Y +F S +D + +W+ ++ Sbjct: 362 PVSVTY-----RFGSVGQDTQLCLWDLTEDILFPHQP 393 Score = 33.3 bits (74), Expect = 0.21, Method: Composition-based stats. Identities = 21/149 (14%), Positives = 45/149 (30%), Gaps = 17/149 (11%) Query: 124 QGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKT------GHL 177 Y+ ++ ++ ++ +VI GH + + F P T + Sbjct: 272 PDGKYIVT------GGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVEEGDPM 325 Query: 178 ILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTET 237 SG ++ + F D + + R F S D + +WD Sbjct: 326 EFSGSDEDFQDLLHFGRDRANSTQSRLSKRNSTDSRPVSVTYRFGSVGQDTQLCLWDLTE 385 Query: 238 G-----KVKTRLHLNSTPADVESRPTNPH 261 + +R ++ + S P + Sbjct: 386 DILFPHQPLSRARTHTNVMNATSPPAGSN 414 >3I2N-A nrPDB Length = 357 Score = 72.2 bits (175), Expect = 5e-13, Method: Composition-based stats. Identities = 38/293 (12%), Positives = 97/293 (33%), Gaps = 41/293 (13%) Query: 108 EVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTA 167 E+E+ + + D +L + P+ + + GH E A Sbjct: 61 EIEKAKPIKCGTFGATSLQQRYLATGDFGGNLHIWNLE----APEMPVYSVKGHKEIINA 116 Query: 168 LKFLPKTGHL-----ILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFT------- 215 + + G I++G D T+K+WD + + + + K +T Sbjct: 117 IDGIGGLGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAY 176 Query: 216 EDCQSFLSSSFDRS-VKIWDTETGKVKTRLHLNSTPADVES--RPTNPHEFIVGLSNSKI 272 + + + +D +K++D ++ ++ + +E + + ++ + K Sbjct: 177 NQEERVVCAGYDNGDIKLFDLRNMALRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKF 236 Query: 273 LHYDDRVSENQGLVQTY--DHHLSSILALKYFPDG-SKFISSSEDKTVRIWENQI----- 324 +D R + H S++ +++ P F+++ + +W+ + Sbjct: 237 HVFDMRTQHPTKGFASVSEKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRS 296 Query: 325 -------------NVPIKQISDTAQHSMPFLNVHPSQNYFC-AQSMDNRIYSF 363 +V + Q + + L+ P + C S D + Sbjct: 297 KKDSEGIEMGVAGSVSLLQNVTLSTQPISSLDWSPDKRGLCVCSSFDQTVRVL 349 Score = 71.8 bits (174), Expect = 5e-13, Method: Composition-based stats. Identities = 52/348 (14%), Positives = 121/348 (34%), Gaps = 51/348 (14%) Query: 151 PKKVIRNYPGHPEGTTALKFLPKTGHLILSGGN---DHTIKIWDFYH-DYECLRDFQGHN 206 P+ + G K++P + + G I++++ H D + LR+ + Sbjct: 7 PQIIAHIQKGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEK-A 65 Query: 207 KPIKALRF---TEDCQSFLSSSFDRSVKIWDTETGK-VKTRLHLNSTPADVESRPTNPH- 261 KPIK F + + + F ++ IW+ E + + + + Sbjct: 66 KPIKCGTFGATSLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGI 125 Query: 262 -----EFIVGLSNSKILHYDDRVSE----NQGLVQTYDHHLSSILALKY----FPDGSKF 308 E + G + + +D R + N VQ + + + + Sbjct: 126 GEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQG--ENKRDCWTVAFGNAYNQEERVV 183 Query: 309 ISSSEDKTVRIWENQINVPIK--QISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLK 366 + ++ +++++ + N+ ++ S+ F S N A S++ + + F ++ Sbjct: 184 CAGYDNGDIKLFDLR-NMALRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMR 242 Query: 367 PKY--KRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDW------------ 412 ++ K K H S + + ++ +G + L W + Sbjct: 243 TQHPTKGFASVSEKAHKSTVWQVRHLPQNRELFLTAGGA-GGLHLWKYEYPIQRSKKDSE 301 Query: 413 -------NTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYV 453 + LL N+ + +PI+ +DW P + +CS + V Sbjct: 302 GIEMGVAGSVSLLQNVTLS-TQPISSLDWSPDKRGLCVCSSFDQTVRV 348 Score = 52.1 bits (123), Expect = 6e-07, Method: Composition-based stats. Identities = 26/225 (11%), Positives = 63/225 (28%), Gaps = 16/225 (7%) Query: 246 LNSTPADVESRPTNPHEFIVG--LSNSKILHYDDRVSENQGLVQTYDHHLSSILALKY-- 301 N T D + P + +G + ++ + + L++ + I + Sbjct: 17 FNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEK-AKPIKCGTFGA 75 Query: 302 -FPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPS------QNYFCAQ 354 + + IW + + + ++ Sbjct: 76 TSLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGIGGLGIGEGAPEIVTG 135 Query: 355 SMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAF----SGDGRYICSGDSKSRLFTW 410 S D + + + K + ++AF + + R +C+G + + Sbjct: 136 SRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYDNGDIKLF 195 Query: 411 DWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 D L I + D +K++ + GK +V D Sbjct: 196 DLRNMALRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFD 240 >3JB9-S nrPDB Length = 488 Score = 67.9 bits (164), Expect = 9e-12, Method: Composition-based stats. Identities = 44/244 (18%), Positives = 85/244 (34%), Gaps = 24/244 (9%) Query: 215 TEDCQSFLSS-SFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKIL 273 + + SF+ D + + D ++ ++ + + V +++ + Sbjct: 218 SPENSSFVLCLHKDELLCL-DIQSNSTLKIFEGSA----LACCWLTSSKIAVATADAISI 272 Query: 274 HYDDRVSENQGLVQTYDHH---LSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQ 330 S V + L+ P G +++S +K I+ + V Sbjct: 273 FEFPVSSSGLQSVGEPTSSIPIDEKVNFLQAHPSGEYLLAASNEK-CYIFSLKSQV---Y 328 Query: 331 ISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLA 390 AQH + L VHP N F A + + F + F HSS +L Sbjct: 329 NITVAQH-ITSLAVHPDGNLFVAGLENGELRFFE---TSSGNELTKFGPHSSPVK--TLQ 382 Query: 391 FSGDGRYIC-SGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAG 449 F +G ++ + + S +F WD S L+ I + + TS+++ S Sbjct: 383 FGENGYWLVVTTNDDSDIFIWDLRKSELVQKIPLQTKVAAVSL----DITSQLLVSSDGE 438 Query: 450 KIYV 453 +YV Sbjct: 439 TLYV 442 Score = 61.4 bits (147), Expect = 9e-10, Method: Composition-based stats. Identities = 35/192 (18%), Positives = 79/192 (41%), Gaps = 10/192 (5%) Query: 130 YPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKI 189 +P + + E+ + H T+L P G+L ++G + ++ Sbjct: 304 HPSGEYLLAASNEKCYIFSLKSQVYNITVAQH---ITSLAVHPD-GNLFVAGLENGELRF 359 Query: 190 WDFYHDYECLRDFQGHNKPIKALRFTEDCQS-FLSSSFDRSVKIWDTETGKVKTRLHLNS 248 ++ E + F H+ P+K L+F E+ ++++ D + IWD ++ ++ L + Sbjct: 360 FETSSGNELTK-FGPHSSPVKTLQFGENGYWLVVTTNDDSDIFIWDLRKSELVQKIPLQT 418 Query: 249 TPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKF 308 A V S + + +H + S++ + H+SSI L + + + Sbjct: 419 KVAAV-SLDITSQLLVSSDGETLYVHIYVKSSKSWRCMS--QTHVSSISNLVWLNELHQL 475 Query: 309 I-SSSEDKTVRI 319 + S+S +R+ Sbjct: 476 LFSTSNGAILRL 487 >5MC6-j nrPDB Length = 397 Score = 65.2 bits (157), Expect = 6e-11, Method: Composition-based stats. Identities = 45/326 (13%), Positives = 90/326 (27%), Gaps = 66/326 (20%) Query: 159 PGHPEGTTALKFLPKTGHLILSGGNDHTIKIWD---FYHDYECLRDFQG--HNKPIKAL- 212 H ++ +S D +K+WD ++ + + H + + Sbjct: 13 KAHDADIFSVS---ACNSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHVD 69 Query: 213 ---RFTEDC---QSFLSSSF------------DRSVKI-----------------WDTET 237 D ++SF D + K+ W + Sbjct: 70 VLQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFWALKW 129 Query: 238 GKVKTRLHLN---STPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLS 294 G RL + +T + H F ++ + E QG V++ Sbjct: 130 GASNDRLLSHRLVATDVKGTTYIWKFHPF--ADESNSLTLNWSPTLELQGTVESPMTPSQ 187 Query: 295 SILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTA-----QHSMPFLNVHPSQN 349 ++ G + + TV+I E P+ +S+ + P + Sbjct: 188 FATSVDISERG-LIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGS 246 Query: 350 YFCAQSMDNRIYSFSLKPKYKRHPKKIFK--GHS---------SAGYGISLAFSGDGRYI 398 N +L HS + + +SL+F+ G + Sbjct: 247 LLAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGETL 306 Query: 399 CSGDSKSRLFTWDWNTSRLLNNIKIP 424 CS +L WD T + + + Sbjct: 307 CSAGWDGKLRFWDVKTKERITTLNMH 332 Score = 54.8 bits (130), Expect = 7e-08, Method: Composition-based stats. Identities = 28/183 (15%), Positives = 64/183 (34%), Gaps = 21/183 (11%) Query: 90 QDIFVHALAEDNLDSEQIEVEE-VSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRC 148 + L Q VE ++ + D RG + + E + R Sbjct: 160 DESNSLTLNWSPTLELQGTVESPMTPSQFATSVDISERGLIATGFNNGTVQISELSTLRP 219 Query: 149 YLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGND----HTIKIWDFYHDYECLRDFQ- 203 + + + ++KF P+ G L+ +D I +++ E + Sbjct: 220 LYNFESQHSMINNSNSIRSVKFSPQ-GSLLAIA-HDSNSFGCITLYETEFG-ERIGSLSV 276 Query: 204 ------------GHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPA 251 H+ + +L F + ++ S+ +D ++ WD +T + T L+++ Sbjct: 277 PTHSSQASLGEFAHSSWVMSLSFNDSGETLCSAGWDGKLRFWDVKTKERITTLNMHCDDI 336 Query: 252 DVE 254 ++E Sbjct: 337 EIE 339 Score = 46.3 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 36/313 (11%), Positives = 82/313 (26%), Gaps = 66/313 (21%) Query: 203 QGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKV-------------KTRLHLNST 249 + H+ I ++ + +S S D +K+WD + K+ LH Sbjct: 13 KAHDADIFSV--SACNSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHVDV 70 Query: 250 PADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLV---------QTYDHHLSSILALK 300 +E + +L Y + V H ALK Sbjct: 71 LQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSF--WALK 128 Query: 301 YFPDGSKFIS---SSED--KTVRIWENQ-----------------INVPIKQISDTAQHS 338 + + +S + D T IW+ + T Sbjct: 129 WGASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPSQF 188 Query: 339 MPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGI-SLAFSGDGRY 397 +++ + + L + + + I S+ FS G Sbjct: 189 ATSVDISERG-LIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSL 247 Query: 398 ICSGDSKSR---LFTWDWNTSRLLNNIKIPGNKP------------ITQVDWHPQETSKV 442 + + + ++ + ++ +P + + + ++ + Sbjct: 248 LAIAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFN-DSGETL 306 Query: 443 ICSGAAGKIYVCD 455 +G GK+ D Sbjct: 307 CSAGWDGKLRFWD 319 >5WLC-LS nrPDB Length = 594 Score = 64.1 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 54/354 (15%), Positives = 101/354 (28%), Gaps = 62/354 (17%) Query: 156 RNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYE-CLRDFQGHNKPIKALRF 214 ++P H +L F P L+L+GG D T++I+ + PI+ F Sbjct: 243 ASHPSHSA-IQSLSFHPSKP-LLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTF 300 Query: 215 -----TEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSN 269 ++ Q+ ++ R + WD ++ H + + SR N Sbjct: 301 YTSLSNQNQQNIFTAGRRRYMHSWDL---SLENLTHSQTAKIEKFSRLYGHESTQRSFEN 357 Query: 270 SKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDK-------------- 315 K+ H + + + + + I L G + + Sbjct: 358 FKVAHLQNSQTNSVHGIVLLQGNNGWINILH-STSGLWLMGCKIEGVITDFCIDYQPISR 416 Query: 316 --------------------------TVRIWENQINVPIKQISDTAQHSM--PFLNVH-- 345 +R W++Q V I +I + P L + Sbjct: 417 GKFRTILIAVNAYGEVWEFDLNKNGHVIRRWKDQGGVGITKIQVGGGTTTTCPALQISKI 476 Query: 346 PSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGIS-LAFSGDGRYICSGDS- 403 + S + + IS L FS DG+ +C Sbjct: 477 KQNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASRA 536 Query: 404 -KSRLFTWDWNTSRLLNNIKIPGN--KPITQVDWHPQETSKVICSGAAGKIYVC 454 K L + + +N G +T V + P + GK+ + Sbjct: 537 VKDALRLVHLPSCSVFSNWPTSGTPLGKVTSVAFSP-SGGLLAVGNEQGKVRLW 589 Score = 46.7 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 22/150 (14%), Positives = 43/150 (28%), Gaps = 7/150 (4%) Query: 272 ILHYDDRVSENQGLVQTYDHHLSSILALKYFP--DGSKFISSSEDKTVRIWENQINVPIK 329 I + D+ +Q ++ AL+ SE V +++ + Sbjct: 444 IRRWKDQGGVGITKIQVGGGTTTTCPALQISKIKQNRWLAVGSESGFVNLYDRNNAMTSS 503 Query: 330 QISDTAQHS-----MPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAG 384 + A + L P C S + + + G Sbjct: 504 TPTPVAALDQLTTTISNLQFSPDGQILCMASRAVKDALRLVHLPSCSVFSNWPTSGTPLG 563 Query: 385 YGISLAFSGDGRYICSGDSKSRLFTWDWNT 414 S+AFS G + G+ + ++ W N Sbjct: 564 KVTSVAFSPSGGLLAVGNEQGKVRLWKLNH 593 Score = 42.1 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 20/151 (13%), Positives = 37/151 (24%), Gaps = 45/151 (29%) Query: 177 LILSGGNDHTIKIWD-----FYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVK 231 + G + ++D + I L+F+ D Q +S Sbjct: 481 WLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMASR----- 535 Query: 232 IWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDH 291 VK L L P+ +G Sbjct: 536 -------AVKDALRLVHLPSCSVFSNWPTSGTPLG------------------------- 563 Query: 292 HLSSILALKYFPDGSKFISSSEDKTVRIWEN 322 + ++ + P G +E VR+W+ Sbjct: 564 ---KVTSVAFSPSGGLLAVGNEQGKVRLWKL 591 Score = 30.9 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 8/30 (26%), Positives = 15/30 (50%), Gaps = 1/30 (3%) Query: 165 TTALKFLPKTGHLILSGGNDHTIKIWDFYH 194 T++ F P +G L+ G +++W H Sbjct: 565 VTSVAFSP-SGGLLAVGNEQGKVRLWKLNH 593 >5AJA-A nrPDB Length = 361 Score = 64.1 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 35/243 (14%), Positives = 73/243 (30%), Gaps = 20/243 (8%) Query: 135 VDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYH 194 VD + + F + P V R G T F + L+L G +K+++ + Sbjct: 10 VDGGCFDRHLIFSRFRPISVFREANEDESGFTCCAFSARERFLML-GTCTGQLKLYNVFS 68 Query: 195 DYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRS--VKIWDTETGKVKTRLHLNSTPAD 252 E + HN I L + D L+S+ +W ++ + + T Sbjct: 69 GQE-EASYNCHNSAITHLEPSRDGSLLLTSATWSQPLSALWGMKS---VFDMKHSFTEDH 124 Query: 253 VESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYD-HHLSSILALKYFPDGSKFISS 311 + + ++G YD + + D + + P + Sbjct: 125 YVEFSKHSQDRVIGTKGDIAHIYDIQTGNKLLTLFNPDLANNYKRNCATFNPTDDLVL-- 182 Query: 312 SEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKR 371 D +W+ + I + + HP+ + + L+ + Sbjct: 183 -NDGV--LWDVRSAQAIHKFDKFNMNISGV--FHPNGLEVIINTE-----IWDLRTFHLL 232 Query: 372 HPK 374 H Sbjct: 233 HTV 235 Score = 46.3 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 30/236 (12%), Positives = 75/236 (31%), Gaps = 27/236 (11%) Query: 224 SSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQ 283 FDR + V + + + + ++G ++ Y+ + + Sbjct: 13 GCFDRHLIFSRFRPISVFREANEDESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEE 72 Query: 284 GLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQIN--VPIKQISDTAQHSM-- 339 +Y+ H S+I L+ DGS ++S+ W ++ +K + D Sbjct: 73 ---ASYNCHNSAITHLEPSRDGSLLLTSAT------WSQPLSALWGMKSVFDMKHSFTED 123 Query: 340 PFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYIC 399 ++ + + + + ++ K ++ F+ + Sbjct: 124 HYVEFSKHSQDRVIGTKGDIAHIYDIQTGNKLLTLFNPDLANNYKR-NCATFNPTDDLVL 182 Query: 400 SGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAAGKIYVCD 455 + L WD +++ ++ N I+ V +HP +I + D Sbjct: 183 ---NDGVL--WDVRSAQAIHKFD-KFNMNISGV-FHPNGLEVII------NTEIWD 225 Score = 35.2 bits (79), Expect = 0.054, Method: Composition-based stats. Identities = 19/131 (14%), Positives = 31/131 (23%), Gaps = 27/131 (20%) Query: 182 GNDHTI-------KIWDFYHDYECLRDFQ---GHNKPIKALRFTEDCQSFLSSSFDRSVK 231 D I I+D + L F +N F L D Sbjct: 132 SQDRVIGTKGDIAHIYDIQTGNKLLTLFNPDLANNYKRNCATFNPTDDLVL---NDGV-- 186 Query: 232 IWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYD- 290 +WD + + + + P I +D R V D Sbjct: 187 LWDVRSAQAIHKFDKFNMNISGVFHPNGLEVII------NTEIWDLRTFHLLHTVPALDQ 240 Query: 291 -----HHLSSI 296 +H ++ Sbjct: 241 CRVVFNHTGTV 251 >2I3T-A nrPDB Length = 341 Score = 63.3 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 35/307 (11%), Positives = 105/307 (34%), Gaps = 23/307 (7%) Query: 152 KKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDF---YHDYECLRDFQGHNKP 208 ++++ + + +K +P L+++ D ++ ++ F + + L+ + + P Sbjct: 1 MQIVQIEQAPKDYISDIKIIPSKSLLLIT-SWDGSLTVYKFDIQAKNVDLLQSLR-YKHP 58 Query: 209 IKALRF--TEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVG 266 + F D Q ++ + +K+ + + + + + I Sbjct: 59 LLCCNFIDNTDLQIYVGTVQGEILKVDLIGSPSFQALTNNEANLGICRICKYGDDKLIAA 118 Query: 267 LSNSKILHYDDRVSENQGL-VQTYDHHLSSILA--LKYFPDGSKFISSSEDKTVRIWENQ 323 + I D R + + V+ + + + + + S+ I + V+ + Sbjct: 119 SWDGLIEVIDPRNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLIVGMNNSQVQWFRLP 178 Query: 324 INVPIKQISDTA--QHSMPFLNVHPS-QNYFCAQSMDNRIYS---FSLKPKYKRHPKKIF 377 + + + ++ + + + P Q + S+D R+ Y + F Sbjct: 179 LCEDDNGTIEESGLKYQIRDVALLPKEQEGYACSSIDGRVAVEFFDDQGDDYNSSKRFAF 238 Query: 378 KGH-------SSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPIT 430 + H + A S+ FS +++ + S + W+ T + + N + Sbjct: 239 RCHRLNLKDTNLAYPVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKNFAKFNEDSVV 298 Query: 431 QVDWHPQ 437 ++ Sbjct: 299 KIACSDN 305 Score = 50.2 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 32/217 (14%), Positives = 73/217 (33%), Gaps = 25/217 (11%) Query: 168 LKFLPKTGHLILSGGNDHTIKIWDFYH---DYECLRDFQGHNKPIKALRFTED-CQSFLS 223 + +++ D I++ D + +++ +N +K FT D S L Sbjct: 105 CRICKYGDDKLIAASWDGLIEVIDPRNYGDGVIAVKNLNSNNTKVKNKIFTMDTNSSRLI 164 Query: 224 SSFDRSVKIW------DTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILH--Y 275 + S W + + G ++ L DV P + + ++ + Sbjct: 165 VGMNNSQVQWFRLPLCEDDNGTIEE-SGLKYQIRDVALLPKEQEGYACSSIDGRVAVEFF 223 Query: 276 DDRVSE-NQGLVQTYDHHL---------SSILALKYFPDGSKFISSSEDKTVRIWENQIN 325 DD+ + N + H + ++++ P ++ D + W Q Sbjct: 224 DDQGDDYNSSKRFAFRCHRLNLKDTNLAYPVNSIEFSPRHKFLYTAGSDGIISCWNLQTR 283 Query: 326 VPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYS 362 IK + + S+ + + S N C + D+ + Sbjct: 284 KKIKNFAKFNEDSV--VKIACSDNILCLATSDDTFKT 318 Score = 44.0 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 23/153 (15%), Positives = 48/153 (31%), Gaps = 22/153 (14%) Query: 159 PGHPEGTTALKFLPKTGHLILSGGNDHTIKI--WDFYHDYECLRD---FQGHN------- 206 G + LPK D + + +D D F+ H Sbjct: 190 SGLKYQIRDVALLPKEQEGYACSSIDGRVAVEFFDDQGDDYNSSKRFAFRCHRLNLKDTN 249 Query: 207 --KPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFI 264 P+ ++ F+ + ++ D + W+ +T K + + V+ + + Sbjct: 250 LAYPVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKNFAKFNEDSVVK-IACSDNILC 308 Query: 265 VGLSNSKILHYDDRVSENQGLVQTYDHHLSSIL 297 + S+ N + QT + + SSI Sbjct: 309 LATSDDTFK-------TNAAIDQTIELNASSIY 334 >3DW8-B nrPDB Length = 447 Score = 59.4 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 55/387 (14%), Positives = 103/387 (26%), Gaps = 133/387 (34%) Query: 162 PEGTTALKFLPKTG--HLILSGGNDHTIKIW----------------------------- 190 E +++LP+ +LS ND TIK+W Sbjct: 93 EEKINKIRWLPQKNAAQFLLS-TNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTT 151 Query: 191 ---------DFYHDYECLRDF-QGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETG-- 238 D + R F H I ++ D +++LS+ D + +W E Sbjct: 152 LRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSA-DDLRINLWHLEITDR 210 Query: 239 -------KVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDH 291 K L E P + + F+ S I D R Sbjct: 211 SFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMR------------- 257 Query: 292 HLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYF 351 S+ D+ +++E + + S+ + S Y Sbjct: 258 -----------------ASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYM 300 Query: 352 CAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGIS-------------LAFSGDGRYI 398 + + + L + P + ++ H + ++G + Sbjct: 301 MTRDY-LSVKVWDLN--MENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVV 357 Query: 399 CSGDSKSRLFTWDWNTSRLLNNIKIPG--------------------------------N 426 +G + +D NT R + ++ N Sbjct: 358 MTGSYNNFFRMFDRNTKRDI-TLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFN 416 Query: 427 KPITQVDWHPQETSKVICSGAAGKIYV 453 K I WHP+E +I +Y+ Sbjct: 417 KKILHTAWHPKEN--IIAVATTNNLYI 441 Score = 48.7 bits (114), Expect = 6e-06, Method: Composition-based stats. Identities = 37/262 (14%), Positives = 86/262 (32%), Gaps = 52/262 (19%) Query: 209 IKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLS 268 I + F + + V I+ E + K + H + ++ EF Sbjct: 31 ISTVEFNHSGELLATGDKGGRVVIFQQE-QENKIQSHSRGEYNVYSTFQSHEPEF----- 84 Query: 269 NSKILHYDDRVSENQGLVQTYDHHLSSILALKYFP--DGSKFISSSEDKTVRIWEN---- 322 +++ + I +++ P + ++F+ S+ DKT+++W+ Sbjct: 85 ---------------DYLKSLEI-EEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERD 128 Query: 323 --QINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGH 380 +K+ + + R+ F + + Sbjct: 129 KRPEGYNLKEEDGRYRDPTTVTTL--------------RVPVFRPMDLMVEASPRRIFAN 174 Query: 381 SSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRL---LNNIKIPGNKPITQVD---- 433 + + S++ + D S D R+ W + + +IK + +T+V Sbjct: 175 AHTYHINSISINSDYETYLSAD-DLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAE 233 Query: 434 WHPQETSKVICSGAAGKIYVCD 455 +HP + + S + G I +CD Sbjct: 234 FHPNSCNTFVYSSSKGTIRLCD 255 Score = 35.6 bits (80), Expect = 0.049, Method: Composition-based stats. Identities = 39/237 (16%), Positives = 69/237 (29%), Gaps = 55/237 (23%) Query: 162 PEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNK-------------- 207 E TA +F P + + + + TI++ D C R H+K Sbjct: 226 TEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDR----HSKLFEEPEDPSNRSFF 281 Query: 208 -----PIKALRFTEDCQSFLSSSFDR-SVKIWDTETGK--------------VKTRLHLN 247 I ++F+ + ++ D SVK+WD L+ N Sbjct: 282 SEIISSISDVKFSHSGRYMMT--RDYLSVKVWDLNMENRPVETYQVHEYLRSKLCSLYEN 339 Query: 248 STPADV-ESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGS 306 D E ++ S + DR ++ ++ + LK P Sbjct: 340 DCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLK--PR-K 396 Query: 307 KFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSF 363 S + I S + HP +N + +N +Y F Sbjct: 397 VCASG----------KRKKDEISVDSLDFNKKILHTAWHPKENIIAVATTNN-LYIF 442 >6CVZ-A nrPDB Length = 351 Score = 59.1 bits (141), Expect = 4e-09, Method: Composition-based stats. Identities = 47/295 (15%), Positives = 93/295 (31%), Gaps = 36/295 (12%) Query: 193 YHDYECLRDFQGHNKPIKALRFTEDCQ-SFLSSSFDRSVKIWDTETGKVKTRLHLNSTPA 251 + + + H K I+ L F+ + LS+S D ++K+ ET V + Sbjct: 61 TANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNAGRPVW 120 Query: 252 DVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKY--------FP 303 + GL+N IL YD R + + +++L Y FP Sbjct: 121 SCCWCLDEANYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSYMPRAASAAFP 180 Query: 304 DGSKFISSSEDKTVRIWENQINVP--------------IKQISDTAQHSMPFLNVHPSQN 349 G + ED + WE +++ Q ++++H + + Sbjct: 181 YGGVLAGTLEDAS--FWEQKMDFSHWPHVLPLEPGGCIDFQTENSSRHCLVTYRPDKNHT 238 Query: 350 YFCAQSMDNRIYSFSLKPKYKR-HPKKIFKGHSSA----GYGISLAFSGDGRYICSGDSK 404 + M+ P F G + I + DG + + Sbjct: 239 TIRSVLMEMSYRLDDTGNPICSCQPVHTFFGGPTCKLLTKNAIFQSPENDGNILVCTGDE 298 Query: 405 --SRLFTWDWNTSRLLNNIKIPGNKPITQ-VDWHPQETSKVIC-SGAAGKIYVCD 455 + WD + LL +++ +P+ + S + + IY + Sbjct: 299 AANSALLWDAASGSLLQDLQTD--QPVLDICPFEVNRNSYLATLTEKMVHIYKWE 351 Score = 38.3 bits (87), Expect = 0.007, Method: Composition-based stats. Identities = 56/357 (15%), Positives = 104/357 (29%), Gaps = 58/357 (16%) Query: 39 PSSNNIHKRKSHFTKSELKRRRKTRKGDGPWGSWSSSDD--ETSQASETQKEDQDIFVHA 96 PSS HK K HF K+ + G+ ++ + SQ S V Sbjct: 3 PSSQGQHKHKYHFQKTFTVSQ----AGNCRIMAYCDALSCLVISQPSPQASFLPGFGVKM 58 Query: 97 LAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIR 156 L+ N+ S Q G + Y RG L + I V++ Sbjct: 59 LSTANMKSSQYIPMHGKQIRGLAFSSYL-RGLLLSA------SLDNTIKLTSLETNTVVQ 111 Query: 157 NYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNK--PIKALRF 214 Y + + + I +G + +I ++D + +++ P+ +L + Sbjct: 112 TYNA-GRPVWSCCWCLDEANYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLSY 170 Query: 215 TED--------CQSFLSSSFDRSVKIWD-------------TETGKVKTRLHLNSTPAD- 252 + D S W+ E G NS+ Sbjct: 171 MPRAASAAFPYGGVLAGTLEDAS--FWEQKMDFSHWPHVLPLEPGGCIDFQTENSSRHCL 228 Query: 253 VESRPTNPHEFIVGLSNSKILHYDDRVSENQGL--VQTYDHHLSS----ILALKYFPDGS 306 V RP H I + DD + V T+ + A+ P+ Sbjct: 229 VTYRPDKNHTTIRSVLMEMSYRLDDTGNPICSCQPVHTFFGGPTCKLLTKNAIFQSPEND 288 Query: 307 -KFISSSED---KTVRIWENQINVPIKQISDTAQHSMPFLNVHP----SQNYFCAQS 355 + + D + +W+ ++ + P L++ P +Y + Sbjct: 289 GNILVCTGDEAANSALLWDAASGSLLQDLQTDQ----PVLDICPFEVNRNSYLATLT 341 >5TF2-A nrPDB Length = 407 Score = 58.7 bits (140), Expect = 5e-09, Method: Composition-based stats. Identities = 38/268 (14%), Positives = 85/268 (31%), Gaps = 32/268 (11%) Query: 102 LDSEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNYPGH 161 + Q + + K + Q +G + + E + R + V ++ Sbjct: 113 FQAHQQQGNKAEKAGSKEQGPRQRKGAAPAEKKCGAETQHEGLELRVENLQAVQTDFS-- 170 Query: 162 PEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSF 221 + + L+ +GG D +++W + L +F+ H I+ L D Sbjct: 171 SDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSLEKVL-EFKAHEGEIEDLALGPDG-KL 228 Query: 222 LSSSFDRSVKIWDTETGKVKTRLH-------LNSTPADVESR--------PTNPHEFIVG 266 ++ D +W + ++ T+LH +STP ++ P F V Sbjct: 229 VTVGRDLKASVW--QKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLFTVQ 286 Query: 267 LSNSKILH--------YDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVR 318 + + ++ +D S L H + L G+ + +V Sbjct: 287 IPHKRLRQPPPCYLTAWD--GSNFLPLRTKSCGHEV-VSCLDVSESGTFLGLGTVTGSVA 343 Query: 319 IWENQINVPIKQISDTAQHSMPFLNVHP 346 I+ + + + + + P Sbjct: 344 IYIAFSLQCLYYVREAHGIVVTDVAFLP 371 Score = 48.3 bits (113), Expect = 6e-06, Method: Composition-based stats. Identities = 28/226 (12%), Positives = 61/226 (26%), Gaps = 29/226 (12%) Query: 235 TETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLS 294 E + + V + G ++ + + E V + H Sbjct: 159 VENLQAVQTDFSSDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSLEK---VLEFKAHEG 215 Query: 295 SILALKYFPDGSKFISSSEDKTVRIWE---------NQINVPIKQIS--DTAQHSMPFLN 343 I L PDG ++ D +W+ Q N P + + Sbjct: 216 EIEDLALGPDGK-LVTVGRDLKASVWQKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVP 274 Query: 344 VHPSQNYFCAQSMDNR---------IYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGD 394 P+ + ++ + ++ K GH L S Sbjct: 275 DQPAGLRLFTVQIPHKRLRQPPPCYLTAWDGSNFLPLRTKSC--GHEV---VSCLDVSES 329 Query: 395 GRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETS 440 G ++ G + + + + L ++ +T V + P++ Sbjct: 330 GTFLGLGTVTGSVAIYIAFSLQCLYYVREAHGIVVTDVAFLPEKGR 375 Score = 41.7 bits (96), Expect = 6e-04, Method: Composition-based stats. Identities = 11/66 (16%), Positives = 23/66 (34%), Gaps = 3/66 (4%) Query: 389 LAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKVICSGAA 448 + F+ D + +G + + W + + K + I + P K++ G Sbjct: 178 VCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGE-IEDLALGPD--GKLVTVGRD 234 Query: 449 GKIYVC 454 K V Sbjct: 235 LKASVW 240 Score = 31.7 bits (70), Expect = 0.59, Method: Composition-based stats. Identities = 21/160 (13%), Positives = 47/160 (29%), Gaps = 28/160 (17%) Query: 99 EDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPPN--------DVDVDLREERISFRCYL 150 + + Q+ +E + + YQ + P+ V + + R CYL Sbjct: 241 QKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLFTVQIPHKRLRQPPPCYL 300 Query: 151 PK------KVIRNYP-GHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQ 203 +R GH + L ++G + G ++ I+ + + Sbjct: 301 TAWDGSNFLPLRTKSCGHE-VVSCLDVS-ESGTFLGLGTVTGSVAIYIAFSLQCLYYVRE 358 Query: 204 GHNKPIKALRFTEDCQS-----------FLSSSFDRSVKI 232 H + + F + S + D ++ Sbjct: 359 AHGIVVTDVAFLPEKGRGPELLGSHETALFSVAVDSRCQL 398 >4FHN-A nrPDB Length = 394 Score = 58.3 bits (139), Expect = 6e-09, Method: Composition-based stats. Identities = 48/295 (16%), Positives = 91/295 (30%), Gaps = 63/295 (21%) Query: 161 HPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDF-----QGHNKPIKALR-- 213 H + P + D+T+++ + + GH+ + + Sbjct: 89 HDGDGN-VNSSPVYSLFLACVCQDNTVRL-IITKNETIITQHVLGGKSGHHNFVNDIDIA 146 Query: 214 --FTEDCQS----FLSSSFDRSVKIWD-TETGKVKTRLHLNSTPADVESRPTNPHEFIVG 266 ++ D + S D ++ IW T+ G + L+S V+ RP+NP++ IVG Sbjct: 147 DVYSADNRLAEQVIASVGDDCTLIIWRLTDEGPILAGYPLSSPGISVQFRPSNPNQLIVG 206 Query: 267 LSNSKILHYDDRVSENQ------------------GLVQTYDHHLSSILA----LKYF-P 303 N I +D ++ + L H S I + +++ Sbjct: 207 ERNGNIRIFDWTLNLSAEENSQTELVKNPWLLTLNTLPLVNTCHSSGIASSLANVRWIGS 266 Query: 304 DGSKFISSSEDKTVRIWENQINVPIKQISDTAQH-----------------SMPFLNVHP 346 DGS ++ + W N +ISD+ S+ HP Sbjct: 267 DGSGILAMCKSGAWLRWNLFANNDYNEISDSTMKLGPKNLLPNVQGISLFPSLLGACPHP 326 Query: 347 S-QNYFCAQ-SMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYIC 399 +YF S I + K + + DG ++ Sbjct: 327 RYMDYFATAHSQHGLIQLINTYEKDSNSIPIQL-----GMPIVDFCWHQDGSHLA 376 Score = 46.0 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 19/131 (14%), Positives = 38/131 (29%), Gaps = 12/131 (9%) Query: 245 HLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSE--NQGLVQTYDHHLSSILALK-- 300 +L+ +V S P ++ + + Q ++ H + + + Sbjct: 87 NLHDGDGNVNSSPVYSLFLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIA 146 Query: 301 --YFPDGSK----FISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHP-SQNYFCA 353 Y D S +D T+ IW PI + + + P + N Sbjct: 147 DVYSADNRLAEQVIASVGDDCTLIIWRLTDEGPILAGYPLSSPGI-SVQFRPSNPNQLIV 205 Query: 354 QSMDNRIYSFS 364 + I F Sbjct: 206 GERNGNIRIFD 216 >5AMS-A nrPDB Length = 431 Score = 57.5 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 31/239 (12%), Positives = 70/239 (29%), Gaps = 21/239 (8%) Query: 202 FQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKT--RLHLNSTPADVESRPTN 259 F H + A+ + + D +W + + K L S + Sbjct: 61 FDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTSE 120 Query: 260 PHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPD-GSKFISSSEDKTVR 318 + + K+L + + Q + + + I+ LK P F + D +V Sbjct: 121 GGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSV- 179 Query: 319 IWENQINVPIKQISDTAQHSMPFLNVHP----------SQNYFCAQSMDNRIYSFSLKPK 368 W QIN + + + + S+D+ I +++ Sbjct: 180 -WCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTG 238 Query: 369 YKRHPKKIFKGHSSAGYGISLAFSG------DGRYICSGDSKSRLFTWDWNTSRLLNNI 421 + + ISL+ + + + G + L + N + ++ Sbjct: 239 QQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHL 297 Score = 50.6 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 12/124 (9%), Positives = 33/124 (26%), Gaps = 2/124 (1%) Query: 286 VQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIK-QISDTAQHSMPFLNV 344 + +D H S+ A+ + P+ + D +W + P S+ + Sbjct: 58 LTYFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSF 117 Query: 345 HPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSK 404 + M ++ + + + + R G + Sbjct: 118 TSEGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTI-ARTFAFGATD 176 Query: 405 SRLF 408 ++ Sbjct: 177 GSVW 180 Score = 39.0 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 28/189 (14%), Positives = 56/189 (29%), Gaps = 26/189 (13%) Query: 178 ILSGGNDHTIKIWDFYHDYECLRD----FQGHNKPIKALRFTE------DCQSFLSSSFD 227 +++ D TI W+ + + + +G P +L + S + Sbjct: 221 LVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNN 280 Query: 228 RSVKIWDTETGKVKTRLHL--------NSTPADVESRPTNP--HEFIVGLSNSKILHYDD 277 + + + G L + A +ES + +GL +IL YD Sbjct: 281 GLLAVINCNNGGAILHLSTVIELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYDT 340 Query: 278 RVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQH 337 + S+ L + D F S + V + + Sbjct: 341 SAWRVRHKFVL----EDSVTKLMFDND-DLFASC-INGKVYQFNARTGQEKFVCVGHNMG 394 Query: 338 SMPFLNVHP 346 + F+ +HP Sbjct: 395 VLDFILLHP 403 >6IYY-A nrPDB Length = 317 Score = 56.0 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 37/255 (14%), Positives = 88/255 (34%), Gaps = 19/255 (7%) Query: 205 HNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHL-NSTPADVESRPTNPHEF 263 H + F +D F + ++++T+ K K + VE + Sbjct: 6 HGNGLLYAGFNQDHGCFA-CGMENGFRVYNTDPLKEKEKQEFLEGGVGHVEMLFRCNYLA 64 Query: 264 IVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQ 323 +VG K++ +DD + ++ + + A+K D + D ++++ Sbjct: 65 LVGGGKKKVMIWDDLKKKTVIEIEF----STEVKAVKLRRDRIVVV---LDSMIKVFTFT 117 Query: 324 INVPIKQISDTAQHSMPFLNVHPSQN---YFCAQSMDNRIYSFSLKPKYKRHPKKIFKGH 380 N + +T + + P+ N + + L P H Sbjct: 118 HNPHQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDL--ASTEKPPVDIPAH 175 Query: 381 SSAGYGISLAFSGDGRYICSGDSKSR-LFTWDWNTSRLLNNI-KIPGNKPITQVDWHPQE 438 G +A + G I + K + +D ++ L+ + + I ++++ Q+ Sbjct: 176 --EGVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRGSQAANIYCINFN-QD 232 Query: 439 TSKVICSGAAGKIYV 453 S + S G +++ Sbjct: 233 ASLICVSSDHGTVHI 247 Score = 55.2 bits (131), Expect = 6e-08, Method: Composition-based stats. Identities = 23/198 (11%), Positives = 59/198 (29%), Gaps = 15/198 (7%) Query: 138 DLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYE 197 + + + CY PK + L L G + +++ D + Sbjct: 119 NPHQLHVFETCYNPKGL-----------CVLCPNSNNSLLAFPGTHTGHVQLVDLASTEK 167 Query: 198 CLRDFQGHNKPIKALRFTEDCQSFLSSSFDRS-VKIWDTETGKVKTRLHLNSTPADVESR 256 D H + + ++S + ++I+DT +G + L S A++ Sbjct: 168 PPVDIPAHEGVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRGSQAANIYCI 227 Query: 257 PTNP--HEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPD-GSKFISSSE 313 N V + + + +++ + S + + + ++ Sbjct: 228 NFNQDASLICVSSDHGTVHIFAAEDPKSKWSFSKFQVPSGSPCICAFGTEPNAVIAICAD 287 Query: 314 DKTVRIWENQINVPIKQI 331 + N I+ + Sbjct: 288 GSYYKFLFNPKGECIRDV 305 >5LTD-A nrPDB Length = 525 Score = 52.1 bits (123), Expect = 4e-07, Method: Composition-based stats. Identities = 36/241 (14%), Positives = 72/241 (29%), Gaps = 33/241 (13%) Query: 198 CLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRP 257 C F G I A++ + L + ++ I+D ++ + S P + + Sbjct: 113 CELTFPG---AILAVKLNRERLVVL---LEETIYIYDINNMRLLHTIETPSNPNGLIALS 166 Query: 258 TNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTV 317 S + L Y H + ++ +G Sbjct: 167 P--------SSENNYLAYPSPQKLAPNPQTEVTLHSNP-QTVR---NGDVI--------- 205 Query: 318 RIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRI-YSFSLKPKYKRHPKKI 376 I++ + P + + + S+ + + S I FS+ K + Sbjct: 206 -IFDAKTLQP-TSVIEAHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQ--- 260 Query: 377 FKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHP 436 F+ + SLAFS D R++ + + + + N IK K P Sbjct: 261 FRRGTYPTKIYSLAFSPDNRFVIASSATETVHIFRLGEEEAANTIKSANKKARLTKAQVP 320 Query: 437 Q 437 Sbjct: 321 N 321 Score = 46.0 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 24/142 (16%), Positives = 49/142 (34%), Gaps = 10/142 (7%) Query: 112 VSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRC-------YLPKKVIRNYPGHPEG 164 +S + Y L P +V L + R + H Sbjct: 165 LSPSSENNYLAYPSPQKLAPNPQTEVTLHSNPQTVRNGDVIIFDAKTLQPTSVIEAHRTS 224 Query: 165 TTALKFLPKTGHLILSGGNDHTI-KIWDFYHDYECLRDFQG-HNKPIKALRFTEDCQSFL 222 A+ L K G L+ + + TI +++ + + +G + I +L F+ D + + Sbjct: 225 LAAIA-LSKDGLLLATASDKGTIIRVFSVATGIKLYQFRRGTYPTKIYSLAFSPDNRFVI 283 Query: 223 SSSFDRSVKIWDTETGKVKTRL 244 +SS +V I+ + + Sbjct: 284 ASSATETVHIFRLGEEEAANTI 305 Score = 43.7 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 14/91 (15%), Positives = 39/91 (42%), Gaps = 3/91 (3%) Query: 187 IKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRS-VKIWDTETGKVKTRLH 245 + I+D + + H + A+ ++D ++S + ++++ TG + Sbjct: 204 VIIFDAKT-LQPTSVIEAHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQFR 262 Query: 246 LNSTPADVESRPTNP-HEFIVGLSNSKILHY 275 + P + S +P + F++ S ++ +H Sbjct: 263 RGTYPTKIYSLAFSPDNRFVIASSATETVHI 293 >2VDU-B nrPDB Length = 450 Score = 51.0 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 35/244 (14%), Positives = 77/244 (31%), Gaps = 16/244 (6%) Query: 18 DEGKSVHEKKNGNLHEDTSYEPSSNNIHKRKSHFTKSELKRRRKTRKGDGPWGSWSSS-- 75 D+ + E +N E + N +K+ +KR G S Sbjct: 46 DDFDKIQESRNTTAKEQQGQSSENENENKKLKSNKGDSIKRTAAKVPSPGLGAPPIYSYI 105 Query: 76 -----DDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLY 130 + S+ D+ + V + + + + ++ + + + Sbjct: 106 RNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDTTVI 165 Query: 131 PPNDVD--VDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTG--HLILSGGNDHT 186 + + I + + ++ GH T + + + I++ D Sbjct: 166 IADKFGDVYSIDINSIPEEKFTQEPIL----GHVSMLTDVHLIKDSDGHQFIITSDRDEH 221 Query: 187 IKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHL 246 IKI + + + GH + ++ +D LS+ D + WD +TGK + Sbjct: 222 IKISHYPQCFIVDKWLFGHKHFVSSICCGKD-YLLLSAGGDDKIFAWDWKTGKNLSTFDY 280 Query: 247 NSTP 250 NS Sbjct: 281 NSLI 284 Score = 43.7 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 30/182 (16%), Positives = 51/182 (28%), Gaps = 12/182 (6%) Query: 248 STPADVESRPTNPHEFIVGLSNSKILHYD-DRVSENQGLVQTYDHHLSSILALKYFPDGS 306 S ++ S+ +L +D D+ S+N ++ A+ D + Sbjct: 103 SYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKRPNAISIAEDDT 162 Query: 307 KFISSSEDKTVRIWE-NQINVPIKQISDTAQHSMPFLNVH----PSQ-NYFCAQSMDNRI 360 I + + V + N I H +VH + D I Sbjct: 163 TVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDRDEHI 222 Query: 361 YSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNN 420 K GH I G + S ++F WDW T + L+ Sbjct: 223 KIS--HYPQCFIVDKWLFGHKHFVSSICC---GKDYLLLSAGGDDKIFAWDWKTGKNLST 277 Query: 421 IK 422 Sbjct: 278 FD 279 Score = 41.7 bits (96), Expect = 6e-04, Method: Composition-based stats. Identities = 26/187 (13%), Positives = 56/187 (29%), Gaps = 25/187 (13%) Query: 165 TTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSS 224 L+ LI +D ++ ++D + + + K F++ + + Sbjct: 105 IRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLR------KRFCFSKRPNAISIA 158 Query: 225 SFDRSVKIWDT--------------ETGKVKTRLHLNSTPADVESRPT-NPHEFIVGLSN 269 D +V I D E + L S DV + H+FI+ Sbjct: 159 EDDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQFIITSDR 218 Query: 270 SKILHYDDRVSENQGLVQT-YDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPI 328 + H +V H + ++ D +S+ D + W+ + + Sbjct: 219 DE--HIKISHYPQCFIVDKWLFGHKHFVSSICCGKD-YLLLSAGGDDKIFAWDWKTGKNL 275 Query: 329 KQISDTA 335 + Sbjct: 276 STFDYNS 282 >5WLC-LH nrPDB Length = 896 Score = 51.0 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 36/172 (20%), Positives = 62/172 (36%), Gaps = 26/172 (15%) Query: 296 ILALKYFPDGSKFIS-----------SSEDKT--VRIW---ENQINVPIKQ-ISDTAQHS 338 I LK+ DG I+ SS+D T ++ W +N+ N +K + + S Sbjct: 495 ITDLKFTKDGQWMITYEIEYPPNDLLSSKDLTHILKFWTKNDNETNWNLKTKVINPHGIS 554 Query: 339 MPFLNVHPSQNYF----CAQSMDN----RIYSFSLKPKYKRHPKKIFKGHSSAGYGISLA 390 +P + PS + DN + +SF K + +SLA Sbjct: 555 VPITKILPSPRSVNNSQGCLTADNNGGLKFWSFDSHESNWCLKKISLPNFNHFSNSVSLA 614 Query: 391 FSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQETSKV 442 +S DG I G L D++T + +++ +D Q + Sbjct: 615 WSQDGSLIFHGFDDK-LQILDFDTFKKFESLENTKTVSEFTLDSEIQTVKLI 665 Score = 49.4 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 19/113 (16%), Positives = 41/113 (36%), Gaps = 5/113 (4%) Query: 238 GKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSIL 297 L N+ + + VG ++ I + ++ H+ S+L Sbjct: 246 SSQTQSLSYNTRYVSSMAIDNMGQQLAVGFASGVISIVSLADLQ----IRLLKWHIDSVL 301 Query: 298 ALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNY 350 +L + DGS +S +K + +W+ + N + + + + P NY Sbjct: 302 SLSFSHDGSYLLSGGWEKVMSLWQLETN-SQQFLPRLNGIIIDCQVLGPQGNY 353 Score = 49.0 bits (115), Expect = 5e-06, Method: Composition-based stats. Identities = 31/200 (15%), Positives = 63/200 (31%), Gaps = 21/200 (10%) Query: 84 ETQKEDQDIFVHALAEDNLD--SEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLRE 141 +QK + + L D +Q EV + ++ + G L DV ++ Sbjct: 160 PSQKAHNSLQSYRLYALTFDDAKKQFEVAHQAEWHNVILSNISSNGKLLAHMCKDVSTKD 219 Query: 142 ERI-----------SFRCYLPKKVI-----RNYPGHPEGTTALKFLPKTGHLILSGGNDH 185 S P I ++ + +++ G + G Sbjct: 220 HEHKSISVVSLFDDSVNLSFPLGSILSSQTQSLSYNTRYVSSMAID-NMGQQLAVGFASG 278 Query: 186 TIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLH 245 I I +R + H + +L F+ D LS +++ + +W ET + Sbjct: 279 VISIVSLADLQ--IRLLKWHIDSVLSLSFSHDGSYLLSGGWEKVMSLWQLETNSQQFLPR 336 Query: 246 LNSTPADVESRPTNPHEFIV 265 LN D + + + + Sbjct: 337 LNGIIIDCQVLGPQGNYYSL 356 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 31/163 (19%), Positives = 58/163 (35%), Gaps = 29/163 (17%) Query: 209 IKALRFTEDCQSFLS-----------SSFDRS--VKIW---DTETGKVKTRLHLNSTPAD 252 I L+FT+D Q ++ SS D + +K W D ET +N Sbjct: 495 ITDLKFTKDGQWMITYEIEYPPNDLLSSKDLTHILKFWTKNDNETNWNLKTKVINPHGIS 554 Query: 253 VESRPTNPHE--------FIVGLSNSKILHYDDRVSENQGLVQTYD----HHLSSILALK 300 V P + +N + + E+ ++ +H S+ ++L Sbjct: 555 VPITKILPSPRSVNNSQGCLTADNNGGLKFWSFDSHESNWCLKKISLPNFNHFSNSVSLA 614 Query: 301 YFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLN 343 + DGS +DK ++I + + + +T S L+ Sbjct: 615 WSQDGSLIFHGFDDK-LQILDFDTFKKFESLENTKTVSEFTLD 656 Score = 40.6 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 17/76 (22%), Positives = 27/76 (35%), Gaps = 6/76 (7%) Query: 339 MPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYI 398 + + + I SL R + K H + +SL+FS DG Y+ Sbjct: 259 VSSMAIDNMGQQLAVGFASGVISIVSLADLQIR----LLKWHIDSV--LSLSFSHDGSYL 312 Query: 399 CSGDSKSRLFTWDWNT 414 SG + + W T Sbjct: 313 LSGGWEKVMSLWQLET 328 Score = 33.6 bits (75), Expect = 0.18, Method: Composition-based stats. Identities = 28/140 (20%), Positives = 51/140 (36%), Gaps = 20/140 (14%) Query: 130 YPPNDVDVDLREERI--------SFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHL---I 178 YPPND+ I + + K + N G T + P++ + Sbjct: 514 YPPNDLLSSKDLTHILKFWTKNDNETNWNLKTKVINPHGISVPITKILPSPRSVNNSQGC 573 Query: 179 LSGGNDHTIKIWDFYHDYE--CLRD-----FQGHNKPIKALRFTEDCQSFLSSSFDRSVK 231 L+ N+ +K W F CL+ F + + +L +++D D+ ++ Sbjct: 574 LTADNNGGLKFWSFDSHESNWCLKKISLPNFNHFSNSV-SLAWSQDGSLIFHGFDDK-LQ 631 Query: 232 IWDTETGKVKTRLHLNSTPA 251 I D +T K L T + Sbjct: 632 ILDFDTFKKFESLENTKTVS 651 >6N8P-A nrPDB Length = 979 Score = 46.3 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 37/263 (14%), Positives = 81/263 (30%), Gaps = 35/263 (13%) Query: 159 PGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDC 218 G P +AL + P + ++ G IK++ E + Q N + + Sbjct: 18 HGFPHQPSALGYSP-SLRILAIGTRSGAIKLY-GAPGVEFMGLHQE-NNAVTQIHLLPGQ 74 Query: 219 QSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDR 278 ++ D S+ +W K + + D P + ++ Sbjct: 75 CQLVTLLDDNSLHLWSL-----KVKGGASELQEDESFTLRGPPGAAPSATQITVVL---- 125 Query: 279 VSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQH- 337 + Y S + + P ED+T+ + ++++ + A+H Sbjct: 126 --PHSSCELLYLGTESGNVFVVQLPAFRAL----EDRTI-----SSDAVLQRLPEEARHR 174 Query: 338 ----SMPFLNVHP-SQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFS 392 + L HP N + + L+ ++ S+ ++ + Sbjct: 175 RVFEMVEALQEHPRDPNQILIGYSRGLVVIWDLQ------GSRVLYHFLSSQQLENIWWQ 228 Query: 393 GDGRYICSGDSKSRLFTWDWNTS 415 DGR + S S W ++ Sbjct: 229 RDGRLLVSCHSDGSYCQWPVSSE 251 Score = 35.2 bits (79), Expect = 0.060, Method: Composition-based stats. Identities = 10/52 (19%), Positives = 22/52 (42%), Gaps = 1/52 (1%) Query: 303 PDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQ 354 P ++ ED TVR W+ V ++ + + + + P++N+ Sbjct: 422 PQRDLLLTGHEDGTVRFWD-ASGVCLRLLYKLSTVRVFLTDTDPNENFSAQG 472 Score = 31.7 bits (70), Expect = 0.74, Method: Composition-based stats. Identities = 14/40 (35%), Positives = 20/40 (50%), Gaps = 2/40 (5%) Query: 163 EGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDF 202 +G T+L P L+L+G D T++ WD CLR Sbjct: 412 DGGTSLTPAPPQRDLLLTGHEDGTVRFWDA--SGVCLRLL 449 Score = 30.6 bits (67), Expect = 1.7, Method: Composition-based stats. Identities = 13/55 (23%), Positives = 20/55 (36%), Gaps = 2/55 (3%) Query: 216 EDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNS 270 L+ D +V+ WD +G L+ ST V T+P+E Sbjct: 422 PQRDLLLTGHEDGTVRFWDA-SGVCLRLLYKLSTV-RVFLTDTDPNENFSAQGED 474 >4AV8-A nrPDB Length = 339 Score = 46.3 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 19/145 (13%), Positives = 48/145 (33%), Gaps = 13/145 (8%) Query: 290 DHHLSSILALKYFPDGSKFISSSEDKT-VRIWENQINVPIKQISDTA-QHSMPFLNVHPS 347 H + + ++ G + S+D T +R+++ V +++ + S+ + P Sbjct: 176 KAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWSPD 235 Query: 348 QNYFCAQSMDNRIYSFSLKP---------KYKRHPKKIFKGHSSAGYGISLAFSGDGRYI 398 + S ++ F + K + K S + + ++ + I Sbjct: 236 GSKLAVVSDKWTLHVFEVFNDAENKRHVLKDWINIKYFQSEWSICNFKLKVSKGSNDCKI 295 Query: 399 CSGDSKSRLFTWDWNTSRLLNNIKI 423 + W RL + K+ Sbjct: 296 AWISDTGLVIVW--PNRRLADTFKL 318 Score = 42.9 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 18/125 (14%), Positives = 39/125 (31%), Gaps = 11/125 (8%) Query: 159 PGHPEGTTALKFLPKTGHLILSGGNDHT-IKIWDFYHDY---ECLRDFQGHNKPIKALRF 214 H ++ L + G ++ + D T I+++ + E R I +R+ Sbjct: 176 KAHANPVKMVR-LNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLD--RTSIIDMRW 232 Query: 215 TEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTP----ADVESRPTNPHEFIVGLSNS 270 + D S ++ +++ R L E N + SN Sbjct: 233 SPDGSKLAVVSDKWTLHVFEVFNDAENKRHVLKDWINIKYFQSEWSICNFKLKVSKGSND 292 Query: 271 KILHY 275 + + Sbjct: 293 CKIAW 297 Score = 42.1 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 13/97 (13%), Positives = 34/97 (35%), Gaps = 6/97 (6%) Query: 202 FQGHNKPIKALRFTEDCQSFLSSSFDRS-VKIWDTETGKVKTRLHLN---STPADVESRP 257 + H P+K +R + S D + ++++ T+ G + ++ D+ P Sbjct: 175 VKAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTSIIDMRWSP 234 Query: 258 TNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLS 294 +V LH + ++ + ++ Sbjct: 235 DGSKLAVVSDKW--TLHVFEVFNDAENKRHVLKDWIN 269 Score = 34.8 bits (78), Expect = 0.080, Method: Composition-based stats. Identities = 12/93 (12%), Positives = 28/93 (30%), Gaps = 4/93 (4%) Query: 321 ENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNR-IYSFSLKPKYKRHPKKIFKG 379 + + V + + + + ++ + S D I F + F+ Sbjct: 164 DAEQVVGKGVLVKAHANPVKMVRLNRKGDMVATCSQDGTLIRVFQTDNGV---LVREFRR 220 Query: 380 HSSAGYGISLAFSGDGRYICSGDSKSRLFTWDW 412 I + +S DG + K L ++ Sbjct: 221 GLDRTSIIDMRWSPDGSKLAVVSDKWTLHVFEV 253 >5K1H-B nrPDB Length = 576 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 28/192 (14%), Positives = 54/192 (28%), Gaps = 20/192 (10%) Query: 215 TEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILH 274 D S + S DR+ W+ V T V P + + I Sbjct: 133 CRDQYSVIFESGDRTSIFWNDVKDPVSIEERARWTETYVRWSPKGTY--LATFHQRGIAL 190 Query: 275 YDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSS------ED-KTVRIWENQINVP 327 + E +Q + H + + + P ++ S +D + + IW+ Sbjct: 191 W---GGEKFKQIQRF-SHQG-VQLIDFSPCERYLVTFSPLMDTQDDPQAIIIWDILTGHK 245 Query: 328 IKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGI 387 + + P +F ++D + + P KK Sbjct: 246 KRGFHCESSAHWPIFKWSHDGKFFARMTLD-TLSIYE-TPSMGLLDKKSL----KISGIK 299 Query: 388 SLAFSGDGRYIC 399 ++S G I Sbjct: 300 DFSWSPGGNIIA 311 >5WLC-LV nrPDB Length = 707 Score = 42.9 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 36/270 (13%), Positives = 98/270 (36%), Gaps = 15/270 (5%) Query: 191 DFYHDYECLRDFQGHNKPIKALRFTEDCQS-FLSSSFDRSVKIWDTETGKVKTRLHLNST 249 ++ + E ++DF+ ++ ++ + D Q + ++ + ++D +K H ++ Sbjct: 42 EYQNRVELIQDFE-FSEASNKIKVSRDGQYCMATGTYKPQIHVYDFANLSLKFDRHTDAE 100 Query: 250 PADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFI 309 D + + + L N + + + ++ + + S + K D Sbjct: 101 NVDFTILSDDWTKSVH-LQNDRSIQFQNKGGLHYT-TRIPKFGRSLVYN-KVNCDLYVGA 157 Query: 310 SSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKY 369 S +E + + + + P K ++ H ++++ A + N + + + + Sbjct: 158 SGNELYRLNLEKGRFLNPFKLDTEGVNH----VSINEVNGLLAAGTETNVVEFWDPRSRS 213 Query: 370 KRHPKKIFKGHSSAGY-GISLAFSGDGRYICSGDSKSRLFTWDWNTSRLLNNIKIPG-NK 427 + + + + + +F DG G S + +D TS + IK G Sbjct: 214 RVSKLYLENNIDNRPFQVTTTSFRNDGLTFACGTSNGYSYIYDLRTSE-PSIIKDQGYGF 272 Query: 428 PITQVDWHPQETS--KVICSGAAGKIYVCD 455 I ++ W + K++ + D Sbjct: 273 DIKKIIWLDNVGTENKIVTC-DKRIAKIWD 301 >4YHC-A nrPDB Length = 468 Score = 41.0 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 20/92 (21%), Positives = 36/92 (39%), Gaps = 2/92 (2%) Query: 204 GHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEF 263 H I + +E+ ++F S DRS+ +WD K L P +++ +P Sbjct: 28 HHQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGN 87 Query: 264 IVGLSNSKILHYDDRVSENQGLVQTYDHHLSS 295 V L + L E+ L+ + +H Sbjct: 88 YVSLFSKDTL--FILNVESPSLMLQHSYHSKP 117 Score = 32.5 bits (72), Expect = 0.39, Method: Composition-based stats. Identities = 15/101 (14%), Positives = 34/101 (33%), Gaps = 3/101 (2%) Query: 161 HPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYH-DYECLRDFQGHNKPIKALRFTEDCQ 219 H + + S G D ++ +WD + + + + +KA+ Sbjct: 29 HQLDILKIAVS-ENYKTFASVGLDRSLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGN 87 Query: 220 SFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNP 260 S D ++ I + E+ + + +S P + P Sbjct: 88 YVSLFSKD-TLFILNVESPSLMLQHSYHSKPNSKLNVFWMP 127 >5WLC-LL nrPDB Length = 643 Score = 40.6 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 41/242 (16%), Positives = 85/242 (35%), Gaps = 20/242 (8%) Query: 165 TTALKFLPKTGH---LILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSF 221 T LK++ I+ G N+ I ++ + + G++ IK + Sbjct: 60 VTCLKWVNLASSDTVAIILGMNNGEIWLYSVLANEVTYKFTTGNSYEIKDIDLM--GNQL 117 Query: 222 LSSSFDRSVKIW--DTETGKVKTRLHLNSTPA--DVESRPTNPHEFIVGLSNSKILHYDD 277 D S + D K+ +N+ + P + +++ I D Sbjct: 118 W--CIDSSDAFYQFDLLQFKLLQHFRINNCVQLNKLTIVPAGDSVAQLLVASHSISLIDI 175 Query: 278 RVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSE-DKTVRIWENQINVPIKQISDTAQ 336 E + +V T+ H+S + L+ FIS +E D+ + +++ + + A+ Sbjct: 176 ---EEKKVVMTFPGHVSPVSTLQVI-TNEFFISGAEGDRFLNVYDIHSG--MTKCVLVAE 229 Query: 337 HSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGR 396 + L+ + + D + F + P KK + I + S DGR Sbjct: 230 SDIKELSHSGQADSIAVTTEDGSLEIF-VDPLVSSSTKKRGNKSKKSSKKIQI-VSKDGR 287 Query: 397 YI 398 + Sbjct: 288 KV 289 >5GRS-A nrPDB Length = 396 Score = 39.0 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 19/89 (21%), Positives = 35/89 (39%), Gaps = 2/89 (2%) Query: 204 GHNKPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEF 263 H I + +E+ ++F S DR + +WD K L P +++ +P Sbjct: 28 HHQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWCTKLVLSKEQMPRTLKAIALDPQGN 87 Query: 264 IVGLSNSKILHYDDRVSENQGLVQTYDHH 292 V L + L E+ L+ + +H Sbjct: 88 YVSLFSKDTL--FILNVESPSLMLQHSYH 114 >4NOX-A nrPDB Length = 746 Score = 38.6 bits (88), Expect = 0.006, Method: Composition-based stats. Identities = 22/197 (11%), Positives = 53/197 (26%), Gaps = 38/197 (19%) Query: 269 NSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPI 328 + + + + + H +++ P G+ S V++W Sbjct: 176 GDTVGVFWNNEKDQPENIVDRQHWTE--TFVQWSPLGTYLTSVHAQG-VQLW---GGASW 229 Query: 329 KQISDTAQHSMPFLNVHPSQNYFCAQSM-----------------DNRIY-SFSLKPKYK 370 ++ + + P + Y S D + Y + ++ Sbjct: 230 SRLRRFPHPFVNLVAFSPGEKYLVTWSNRPIQIPDSGHPVLTLDDDGKNYIIWDIETARP 289 Query: 371 RHPKKIFKGHSSAGYGIS---------LAFSGDGRYICSGDSKSRLFTWDWNTSRLL--N 419 H +S D +Y+ + + + ++ LL Sbjct: 290 LRSFAQQDIHPEEHGPKKGPPKFPWPVFKWSADDKYVARLNQGTSISIYELPKMNLLDKQ 349 Query: 420 NIKIPGNKPITQVDWHP 436 +KI G + +W P Sbjct: 350 AVKIEG---VMDFEWAP 363 >6NAU-A nrPDB Length = 334 Score = 38.3 bits (87), Expect = 0.007, Method: Composition-based stats. Identities = 25/168 (14%), Positives = 55/168 (32%), Gaps = 33/168 (19%) Query: 262 EFIVGLSNSKIL---HYDDRVSENQGLVQTYDH-HLSSILALKYFPDGSKF--------- 308 F + + +D E +V+ + H ++I PD Sbjct: 99 VFSASYNQGCVSVTPLHDGLPGETITVVEGLEGCHSANI-----SPDNRTLWVPALKQDR 153 Query: 309 ---ISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNY-FCAQSMDNRIYSFS 364 + S+D + +++ + HP+Q Y +C +++ I + Sbjct: 154 ICLFTLSDDGFL------SAQEPAEVTTVEGAGPRHMVFHPNQQYGYCVNELNSSIDVWE 207 Query: 365 LK-PKYKRHPKKIF----KGHSSAGYGISLAFSGDGRYICSGDSKSRL 407 LK PK + S + + + DGR++ + D + + Sbjct: 208 LKDPKGNIECVQTLDMMPPDFSGVRWAADIHITPDGRHLYACDRTASI 255 >6IGB-A nrPDB Length = 364 Score = 35.9 bits (81), Expect = 0.039, Method: Composition-based stats. Identities = 22/160 (13%), Positives = 51/160 (31%), Gaps = 28/160 (17%) Query: 266 GLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDK---------- 315 ++ +D +G ++ H S+ L + PD +E+ Sbjct: 15 SSEGIQVYRFDGADGSVKGPLRV--AHTSNPSYLTFAPDQRTLFVVNENGRGGKGDTVGR 72 Query: 316 -TVRIWENQIN--VPIKQISDTAQHSMPFLNVHPSQNYFCAQSM----DNRIYSFSLKPK 368 T ++ I Q+ A H + ++ Y + + + ++ Sbjct: 73 ATSYRFDPISGRLQQISQVQTLADHP-TYSSLSHDGRYLFVANYSVQPEGSVAVLPVRAD 131 Query: 369 YKRHPKKIFKGHSSA--------GYGISLAFSGDGRYICS 400 P + H ++ G+ S+ S DG+Y+ + Sbjct: 132 GSLAPVVQVESHQASKVHPRQVSGHVHSVVSSPDGQYLFA 171 >5CWW-B nrPDB Length = 595 Score = 35.2 bits (79), Expect = 0.058, Method: Composition-based stats. Identities = 19/147 (12%), Positives = 44/147 (29%), Gaps = 20/147 (13%) Query: 284 GLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLN 343 L Q + S P +K SS D + + I + L Sbjct: 68 DLAQLKESWESRPSRSSVGPTSTKKDSSDFD------DGAATAGYRIIKTPVADDIRQLV 121 Query: 344 VHPSQNYFCAQSM----------DNRIYSFSLKPKYKRHPKKIFKGH-SSAGYGISLAFS 392 + P+Q++ + + ++ P + H +S +S + Sbjct: 122 MSPNQDFLAVLTSHTVHICILPDSSHLHIQDTTPFKPKFWTLGPTTHVTSRSAVVSAVWH 181 Query: 393 G---DGRYICSGDSKSRLFTWDWNTSR 416 +G + + + + W+ +T+ Sbjct: 182 PLGVNGHALVTVTEDAIVRVWELSTAD 208 Score = 34.4 bits (77), Expect = 0.11, Method: Composition-based stats. Identities = 15/93 (16%), Positives = 32/93 (34%), Gaps = 10/93 (10%) Query: 235 TETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLS 294 + L S + P + H I + K + + + S Sbjct: 121 VMSPNQDFLAVLTSHTVHICILPDSSHLHIQDTTPFKPKFWTLGPTTHVTS-------RS 173 Query: 295 SILALKYFP---DGSKFISSSEDKTVRIWENQI 324 ++++ + P +G ++ +ED VR+WE Sbjct: 174 AVVSAVWHPLGVNGHALVTVTEDAIVRVWELST 206 Score = 33.3 bits (74), Expect = 0.23, Method: Composition-based stats. Identities = 23/148 (15%), Positives = 44/148 (29%), Gaps = 16/148 (10%) Query: 60 RKTRKGDGPW--GSWSSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYG 117 ++ R GD SW S +S + K+D F A + V + Sbjct: 62 KQIRWGDLAQLKESWESRPSRSSVGPTSTKKDSSDFDDGAATAGYRIIKTPVAD--DIRQ 119 Query: 118 KSEKDYQGRGYLYPPNDVDV-----DLREERISFRCYLPKKVIRNYPGH----PEGTTAL 168 Q + + V + + PK H +A+ Sbjct: 120 LVMSPNQDFLAVLTSHTVHICILPDSSHLHIQDTTPFKPKFWTLGPTTHVTSRSAVVSAV 179 Query: 169 KFLPK--TGHLILSGGNDHTIKIWDFYH 194 + P GH +++ D +++W+ Sbjct: 180 -WHPLGVNGHALVTVTEDAIVRVWELST 206 >2EEP-A nrPDB Length = 706 Score = 34.4 bits (77), Expect = 0.10, Method: Composition-based stats. Identities = 15/122 (12%), Positives = 43/122 (35%), Gaps = 16/122 (13%) Query: 337 HSMPFLNVHPSQ------NYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLA 390 P ++ HP + Y A + + + + + + G + +L+ Sbjct: 206 KPTPIVDYHPLEAESKPLYYPMAGTPSHHV-TVGIYHLATGKTVYLQTGEPKEKFLTNLS 264 Query: 391 FSGDGRYICSGD-----SKSRLFTWDWNTSRLLNNI----KIPGNKPITQVDWHPQETSK 441 +S D + + ++ ++ +D T R + + +P+ + + P ++ Sbjct: 265 WSPDENILYVAEVNRAQNECKVNAYDAETGRFVRTLFVETDKHYVEPLHPLTFLPGSNNQ 324 Query: 442 VI 443 I Sbjct: 325 FI 326 >5BPT-A nrPDB Length = 741 Score = 34.4 bits (77), Expect = 0.11, Method: Composition-based stats. Identities = 15/100 (15%), Positives = 35/100 (35%), Gaps = 5/100 (5%) Query: 336 QHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDG 395 H + FL P ++ + + L + + ++ LA+ DG Sbjct: 13 PHEIIFLAWSPKRDLIALVNKAGEVLLHRLANIQRV--WSLPPNENTGKEVTCLAWRPDG 70 Query: 396 RYICSGDSK-SRLFTWDWNTSRLLNNIKIPGNKPITQVDW 434 + + G + ++ D L++ + PI+ + W Sbjct: 71 KILAFGLADTKKVILCDVEKPESLHSFSL--ETPISCMQW 108 Score = 32.9 bits (73), Expect = 0.27, Method: Composition-based stats. Identities = 18/143 (12%), Positives = 40/143 (27%), Gaps = 22/143 (15%) Query: 129 LYPPNDVDVDLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIK 188 + P V I F + PK+ + H + + + Sbjct: 1 MPPFRQVGEKQLPHEIIFLAWSPKRDLIALVNKAGEVL--------LHRLA-----NIQR 47 Query: 189 IWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFD-RSVKIWDTETGKVKTRLHLN 247 +W + + K + L + D + D + V + D E + L Sbjct: 48 VWSLPPN-------ENTGKEVTCLAWRPDGKILAFGLADTKKVILCDVEKPESLHSFSLE 100 Query: 248 STPADVESRPTN-PHEFIVGLSN 269 + + ++ N + + N Sbjct: 101 TPISCMQWMEVNVENSVLTSFYN 123 >5OLJ-A nrPDB Length = 723 Score = 33.6 bits (75), Expect = 0.18, Method: Composition-based stats. Identities = 33/261 (12%), Positives = 87/261 (33%), Gaps = 22/261 (8%) Query: 189 IWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFDRSVKI----WDTE-----TGK 239 ++D+ ++ H + F+ D + D ++ I +DTE G+ Sbjct: 122 VYDYDVRRNLVKPLSEHVGKVMIPTFSPDGRMVAFV-RDNNIFIKKFDFDTEVQVTTDGQ 180 Query: 240 VKTRLHL-NSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILA 298 + + L+ + E TN ++ S R E+ + + Sbjct: 181 INSVLNGATDWVYEEEFGVTN----LMSWSADNAFLAFVRSDESAVPEYRMPMYEDKLYP 236 Query: 299 LKYFPDGSKFISSSEDKTVRIWEN-QINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMD 357 Y K + ++ ++ N + A +P + + + +++ Sbjct: 237 EDYTYKYPKAGEKNSTVSLHLYNVADRNTKSVSLPIDADGYIPRIAFTDNADELAVMTLN 296 Query: 358 ---NRIYSFSLKPKY---KRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWD 411 N + + PK K + + K + + + +L F+ G + + + Sbjct: 297 RLQNDFKMYYVHPKSLVPKLILQDMNKRYVDSDWIQALKFTAGGGFAYVSEKDGFAHIYL 356 Query: 412 WNTSRLLNNIKIPGNKPITQV 432 ++ +++ GN +T++ Sbjct: 357 YDNKGVMHRRITSGNWDVTKL 377 >6FYY-p nrPDB Length = 763 Score = 33.6 bits (75), Expect = 0.20, Method: Composition-based stats. Identities = 15/126 (11%), Positives = 32/126 (25%), Gaps = 27/126 (21%) Query: 315 KTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPK 374 KT W + N + S ++ P Y + + Sbjct: 209 KTSVFWNSMFNEEDSLVESRENWSTNYVRFSPKGTYLFSYHQQG----VTAWGGPNFDRL 264 Query: 375 KIFKGHSSAGYGISLAFSGDGRYICSGDSK-------------------SRLFTWDWNTS 415 + F H + S + +Y+ + ++ +L WD + Sbjct: 265 RRFY-HPDVRNS---SVSPNEKYLVTFSTEPIIVEEDNEFSPFTKKNEGHQLCIWDIASG 320 Query: 416 RLLNNI 421 L+ Sbjct: 321 LLMATF 326 >5BPW-A nrPDB Length = 843 Score = 32.9 bits (73), Expect = 0.29, Method: Composition-based stats. Identities = 8/69 (11%), Positives = 24/69 (34%), Gaps = 8/69 (11%) Query: 188 KIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSSSFD-RSVKIWDTETGKVKTRLHL 246 ++W F + + K + L + D + + D + + + D E + + Sbjct: 54 RVWSFPPN-------ENTGKEVTCLAWRPDGKLLAFALADTKKIVLCDVEKPESLHSFSV 106 Query: 247 NSTPADVES 255 + + + Sbjct: 107 EAPVSCMHW 115 >4U1F-A nrPDB Length = 497 Score = 32.9 bits (73), Expect = 0.33, Method: Composition-based stats. Identities = 15/126 (11%), Positives = 32/126 (25%), Gaps = 27/126 (21%) Query: 315 KTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLKPKYKRHPK 374 KT W + N + S ++ P Y + + Sbjct: 41 KTSVFWNSMFNEEDSLVESRENWSTNYVRFSPKGTYLFSYHQQG----VTAWGGPNFDRL 96 Query: 375 KIFKGHSSAGYGISLAFSGDGRYICSGDSK-------------------SRLFTWDWNTS 415 + F H + S + +Y+ + ++ +L WD + Sbjct: 97 RRFY-HPDVRNS---SVSPNEKYLVTFSTEPIIVEEDNEFSPFTKKNEGHQLCIWDIASG 152 Query: 416 RLLNNI 421 L+ Sbjct: 153 LLMATF 158 >5XJC-J nrPDB Length = 848 Score = 32.9 bits (73), Expect = 0.35, Method: Composition-based stats. Identities = 13/74 (17%), Positives = 25/74 (33%) Query: 38 EPSSNNIHKRKSHFTKSELKRRRKTRKGDGPWGSWSSSDDETSQASETQKEDQDIFVHAL 97 E + + +R ++K+RRK + DG W D + + + A Sbjct: 764 EFGTASDKERVDKLMPEKVKKRRKVQTDDGSDAGWEEYFDYIFPEDAANQPNLKLLAMAK 823 Query: 98 AEDNLDSEQIEVEE 111 E+ + E Sbjct: 824 LWKKQQQEKEDAEH 837 >6AHD-X nrPDB Length = 376 Score = 32.5 bits (72), Expect = 0.36, Method: Composition-based stats. Identities = 14/77 (18%), Positives = 24/77 (31%) Query: 27 KNGNLHEDTSYEPSSNNIHKRKSHFTKSELKRRRKTRKGDGPWGSWSSSDDETSQASETQ 86 K N + D +P + + + + + KT K P+G W E E Sbjct: 252 KEKNKNSDGGSDPETQKEKSIQKQNSLGSNEEKSKTLKKSNPYGEWQEIKQEVESHEEVD 311 Query: 87 KEDQDIFVHALAEDNLD 103 E ++ D Sbjct: 312 LELPSTENEYVSTSEAD 328 >3AZQ-A nrPDB Length = 662 Score = 32.5 bits (72), Expect = 0.39, Method: Composition-based stats. Identities = 12/103 (11%), Positives = 29/103 (28%), Gaps = 17/103 (16%) Query: 310 SSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIYSFSLK--- 366 S++ D++ ++++SD A + + P + D+ + Sbjct: 171 SAAADRSA----------VRELSDDAHRFVTGPRLSPDGRQAVWLAWDHPRMPWEGTELK 220 Query: 367 ----PKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDSKS 405 + R ++ DG I + D Sbjct: 221 TARVTEDGRFADTRTLLGGPEEAIAQAEWAPDGSLIVATDRTG 263 >6G18-v nrPDB Length = 552 Score = 31.3 bits (69), Expect = 0.89, Method: Composition-based stats. Identities = 18/110 (16%), Positives = 40/110 (36%), Gaps = 1/110 (0%) Query: 25 EKKNGNLHEDTSYEPSSNNIHKRKSHFTKSELKRRRKTRKGDGPWGSWSSSDDETSQASE 84 + KN E + + S + ++ + R + +G + S ++ + S Sbjct: 322 DDKNIETKEGSEFSFSDGEVAEKAEVYGSENESERNCLEESEGCYCRSSGDPEQIKEDSL 381 Query: 85 TQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPPND 134 ++ E D + E N E+I+ + V + + + R Y D Sbjct: 382 SE-ESADARSFEMTEFNQALEEIKGQVVENNSVTEFSEEKNRTENYNRQD 430 >5ZC2-B nrPDB Length = 315 Score = 30.9 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 21/117 (17%), Positives = 33/117 (28%), Gaps = 14/117 (11%) Query: 156 RNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNK---PIKAL 212 + G G TA F S D + +W R F+ I + Sbjct: 36 QTSSGERVGVTANSFN--------SVSLDPALVLWSIDKKSSSYRIFEEATHFGVNILSA 87 Query: 213 RFTEDCQSFLSSSFDRSVKI-WDTETGKVKTRLHLNSTPADVESRPT--NPHEFIVG 266 E F S D+ I +D G + + ++ H I+G Sbjct: 88 AQIELSNRFARRSEDKFANIEFDLGVGNIPLFKNCSAAFECERYNIVEGGDHWIIIG 144 >5SUM-A nrPDB Length = 468 Score = 30.9 bits (68), Expect = 1.2, Method: Composition-based stats. Identities = 8/35 (22%), Positives = 16/35 (45%) Query: 170 FLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQG 204 G +L GG D ++I+D + ++ + G Sbjct: 372 IHVHDGKYLLQGGLDRYVRIFDIKTNKMLVKVYVG 406 Score = 30.2 bits (66), Expect = 1.9, Method: Composition-based stats. Identities = 10/33 (30%), Positives = 19/33 (57%) Query: 216 EDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNS 248 D + L DR V+I+D +T K+ ++++ S Sbjct: 375 HDGKYLLQGGLDRYVRIFDIKTNKMLVKVYVGS 407 Score = 30.2 bits (66), Expect = 2.1, Method: Composition-based stats. Identities = 7/39 (17%), Positives = 19/39 (48%) Query: 304 DGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFL 342 DG + D+ VRI++ + N + ++ ++ + + Sbjct: 376 DGKYLLQGGLDRYVRIFDIKTNKMLVKVYVGSRINFIVM 414 >6IRA-D nrPDB Length = 853 Score = 30.9 bits (68), Expect = 1.2, Method: Composition-based stats. Identities = 19/85 (22%), Positives = 36/85 (42%), Gaps = 5/85 (5%) Query: 283 QGLVQTYDHHLSSILALKYFPDGSKFIS---SSEDKTVRIWENQINVPIKQISDTAQHSM 339 ++Q YD H+ S++ FP +FIS ++ D + W+ Q + + + A+ + Sbjct: 159 LKIMQDYDWHVFSLVT-TIFPGYREFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQV 217 Query: 340 PFLNVHPSQNYFCAQSMDNRIYSFS 364 +H S S D + S Sbjct: 218 QLKKIH-SSVILLYCSKDEAVLILS 241 >5TXC-A nrPDB Length = 705 Score = 30.6 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 8/56 (14%), Positives = 19/56 (33%) Query: 169 KFLPKTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFLSS 224 ++ P HL + +++W E I+ +++ +D S Sbjct: 133 RWSPSGTHLAYLRQDQGRVRVWRASVKGEGASPVIEDAYDIEDVQWLDDNTLIYSG 188 >2QT9-A nrPDB Length = 766 Score = 30.6 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 19/137 (13%), Positives = 40/137 (29%), Gaps = 34/137 (24%) Query: 201 DFQGHNKPIKALRFTEDCQSFL-------------SSSFDRSVKIWDTETGKVKTRLHLN 247 F I + D Q L ++S+D I+D ++ T + Sbjct: 94 TFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYD----IYDLNKRQLITEERIP 149 Query: 248 STPADVESRPTNPHEFIVGLSNSKILH------YDDRVSENQGLVQTYDHHLSSIL---- 297 + V P V ++ + Y + + ++ Y+ + Sbjct: 150 NNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDII--YNGITDWVYEEEV 207 Query: 298 -----ALKYFPDGSKFI 309 AL + P+G+ Sbjct: 208 FSAYSALWWSPNGTFLA 224 >1LL6-A nrPDB Length = 392 Score = 30.6 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 24/152 (15%), Positives = 53/152 (34%), Gaps = 16/152 (10%) Query: 257 PTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKT 316 P N ++ + + + ++ + G H+S++ P+ + F S DK Sbjct: 181 PQNYNKLKLAEMDKYLDFWNLMAYDFSGSWDKVSGHMSNVFPSTTKPESTPF---SSDKA 237 Query: 317 VRIWENQINVPIKQISDTAQHSMPFLNVHPSQ-----NYFCAQSMDNRIYSFSLKPKYKR 371 V+ + + VP +I N S +N ++ + K Sbjct: 238 VKDY-IKAGVPANKIVLGMPLYGRAFA-STDGIGTSFNGVGGGSWENGVWDY------KD 289 Query: 372 HPKKIFKGHSSAGYGISLAFSGDGRYICSGDS 403 P++ + S ++ + RY+ S D+ Sbjct: 290 MPQQGAQVTELEDIAASYSYDKNKRYLISYDT 321 >1K3I-A nrPDB Length = 656 Score = 30.2 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 20/102 (19%), Positives = 27/102 (26%), Gaps = 9/102 (8%) Query: 302 FPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFLNVHPSQNYFCAQSMDNRIY 361 P G SS W+ + + +H M + N + N Sbjct: 214 SPGGITLTSS--------WDPSTGIVSDRTVTVTKHDMFCPGISMDGNGQIVVTGGNDAK 265 Query: 362 SFSLKPKYKRHPKKIFKGHSSAGYGISLAFSGDGRYICSGDS 403 SL + GY S S DGR G S Sbjct: 266 KTSLYDSSSDSWIPGPDMQVARGYQSSATMS-DGRVFTIGGS 306 >3R3L-A nrPDB Length = 582 Score = 30.2 bits (66), Expect = 2.1, Method: Composition-based stats. Identities = 8/39 (20%), Positives = 13/39 (33%), Gaps = 2/39 (5%) Query: 401 GDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQET 439 + WD + LLNN G P + ++ Sbjct: 155 AGRDGVVRVWDVKNAELLNN--QFGTMPSLTLACLTKQG 191 >3MWP-A nrPDB Length = 577 Score = 30.2 bits (66), Expect = 2.1, Method: Composition-based stats. Identities = 8/39 (20%), Positives = 13/39 (33%), Gaps = 2/39 (5%) Query: 401 GDSKSRLFTWDWNTSRLLNNIKIPGNKPITQVDWHPQET 439 + WD + LLNN G P + ++ Sbjct: 163 AGRDGVVRVWDVKNAELLNN--QFGTMPSLTLACLTKQG 199 >5A31-O nrPDB Length = 755 Score = 30.2 bits (66), Expect = 2.2, Method: Composition-based stats. Identities = 25/157 (15%), Positives = 47/157 (29%), Gaps = 15/157 (9%) Query: 18 DEGKSVHEKKNGNLHEDTSYEPSSNNIHKRKSHFTKSELKRRRKTRKGDGPWGSWSSSDD 77 DE K+V ED E +S + +RK + ++ R + GP + Sbjct: 165 DENKTV---------EDADMELTSRDEGERKMEKEELDVSVREEEVSCSGPLSQKQAEFF 215 Query: 78 ETSQASETQKEDQDIFVHALAEDNLDSEQIEVEEVSHFYGKSEKDYQGRGYLYPPNDVDV 137 + QAS + ++ A + L++ + +E Y DV Sbjct: 216 LSQQASLLKNDETKALTPASLQKELNNL------LKFNPDFAEAHYLSYLNNLRVQDVFS 269 Query: 138 DLREERISFRCYLPKKVIRNYPGHPEGTTALKFLPKT 174 F + G +L++ Sbjct: 270 STHSLLHYFDRLILTGAESKSNGEEGYGRSLRYAALN 306 >4DYK-A nrPDB Length = 451 Score = 29.8 bits (65), Expect = 2.7, Method: Composition-based stats. Identities = 14/61 (22%), Positives = 23/61 (37%) Query: 47 RKSHFTKSELKRRRKTRKGDGPWGSWSSSDDETSQASETQKEDQDIFVHALAEDNLDSEQ 106 R+ +LK + R GP ++ SDD+ Q +E + E + EQ Sbjct: 172 RQGMALFDDLKHHPRIRIAFGPHAPYTVSDDKLEQILVLTEELDASIQMHVHETAFEVEQ 231 Query: 107 I 107 Sbjct: 232 A 232 >5JN2-A nrPDB Length = 525 Score = 29.8 bits (65), Expect = 2.8, Method: Composition-based stats. Identities = 19/142 (13%), Positives = 41/142 (28%), Gaps = 15/142 (10%) Query: 235 TETGKVKTRLHLNSTPADVESRPTNPHEFIVG------------LSNSKILHYDDRVSEN 282 ++ +L + E + ++VG +S + D Sbjct: 115 LREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIR 174 Query: 283 QGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFL 342 Q L H + I+ P+ S S+D +RI + ++ + Sbjct: 175 QVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAY 234 Query: 343 NVHPSQNYFCAQSMDNRIYSFS 364 + P + D + +S Sbjct: 235 YIAP---EVLHGTYDEKCDVWS 253 >3MA6-A nrPDB Length = 298 Score = 29.8 bits (65), Expect = 2.8, Method: Composition-based stats. Identities = 19/142 (13%), Positives = 41/142 (28%), Gaps = 15/142 (10%) Query: 235 TETGKVKTRLHLNSTPADVESRPTNPHEFIVG------------LSNSKILHYDDRVSEN 282 ++ +L + E + ++VG +S + D Sbjct: 80 LREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIR 139 Query: 283 QGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWENQINVPIKQISDTAQHSMPFL 342 Q L H + I+ P+ S S+D +RI + ++ + Sbjct: 140 QVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAY 199 Query: 343 NVHPSQNYFCAQSMDNRIYSFS 364 + P + D + +S Sbjct: 200 YIAP---EVLHGTYDEKCDVWS 218 >5HAX-A nrPDB Length = 742 Score = 29.4 bits (64), Expect = 3.1, Method: Composition-based stats. Identities = 7/42 (16%), Positives = 14/42 (33%) Query: 181 GGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFTEDCQSFL 222 D ++ +WD+ H L ++ I A+ Sbjct: 86 ASIDSSLFLWDYTHPNPELIGYEEATHTITAVALVPPKPGVF 127 >3OQJ-A nrPDB Length = 257 Score = 29.4 bits (64), Expect = 3.6, Method: Composition-based stats. Identities = 18/111 (16%), Positives = 36/111 (32%), Gaps = 1/111 (0%) Query: 49 SHFTKSELKRRRKTRKGDGPWGSWSSSDDETSQASETQKEDQDIFVHALAEDNLDSEQIE 108 + LKRRR G P+ S S D + +E Q + V ++ + + Sbjct: 19 TQNCNEILKRRRHVLVGISPFNSRFSEDYIHRLIAWAVREFQSVSVLLAGKEAANLLEAL 78 Query: 109 -VEEVSHFYGKSEKDYQGRGYLYPPNDVDVDLREERISFRCYLPKKVIRNY 158 ++ + R + + E+ +F + + RN Sbjct: 79 GTPHGKAERKVRKEVSRNRRFAEKALEAHGGNPEDIHTFSDFANQTAYRNL 129 >1Q0Y-L nrPDB Length = 212 Score = 28.6 bits (62), Expect = 6.2, Method: Composition-based stats. Identities = 7/36 (19%), Positives = 13/36 (36%) Query: 173 KTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKP 208 + S T + W+ + Y C +GH+ Sbjct: 171 SNNKYMASSYLTLTARAWERHSSYSCQVTHEGHSSN 206 >1ZXN-A nrPDB Length = 400 Score = 28.2 bits (61), Expect = 7.4, Method: Composition-based stats. Identities = 18/104 (17%), Positives = 32/104 (30%), Gaps = 9/104 (8%) Query: 210 KALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGL-S 268 + F D F S D+ D V+ + + DV+ + G S Sbjct: 187 TCITFQPDLSKFKMQSLDK-----DIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRS 241 Query: 269 NSKILHYD--DRVSENQGLVQTYDHHLSSILALKYFPDGSKFIS 310 + D D + ++ +H + L G + IS Sbjct: 242 YVDMYLKDKLDETGNSLKVIHEQVNHRWEV-CLTMSEKGFQQIS 284 >1JN6-A nrPDB Length = 210 Score = 28.2 bits (61), Expect = 8.0, Method: Composition-based stats. Identities = 7/34 (20%), Positives = 12/34 (35%) Query: 173 KTGHLILSGGNDHTIKIWDFYHDYECLRDFQGHN 206 + S T + W+ + Y C +GH Sbjct: 171 SNNKYMASSYLTLTARAWERHSSYSCQVTHEGHT 204 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.305 0.122 0.315 Lambda K H 0.267 0.0379 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,645,155 Number of Sequences: 36641 Number of extensions: 643442 Number of successful extensions: 5661 Number of sequences better than 10.0: 183 Number of HSP's better than 10.0 without gapping: 256 Number of HSP's successfully gapped in prelim test: 65 Number of HSP's that attempted gapping in prelim test: 1574 Number of HSP's gapped (non-prelim): 1160 length of query: 455 length of database: 10,336,785 effective HSP length: 100 effective length of query: 355 effective length of database: 6,672,685 effective search space: 2368803175 effective search space used: 2368803175 T: 11 A: 40 X1: 16 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.5 bits) S2: 60 (27.8 bits)