BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P40160 (425 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 6FAI-l nrPDB 880 0.0 4GYG-A nrPDB 340 5e-94 6G18-v nrPDB 296 8e-81 6FDN-A nrPDB 291 5e-79 1TQM-A nrPDB 99 4e-21 1ZP9-A nrPDB 65 7e-11 6G5I-z nrPDB 59 4e-09 4OTP-A nrPDB 58 9e-09 2XS0-A nrPDB 35 0.086 1JNK-A nrPDB 33 0.17 3FI2-A nrPDB 33 0.19 3E7O-A nrPDB 33 0.19 5AWM-A nrPDB 33 0.20 5YK0-A nrPDB 32 0.36 2YCR-A nrPDB 31 1.1 3I6U-A nrPDB 30 1.7 3OMV-A nrPDB 30 2.8 5ZTN-A nrPDB 29 4.2 4UY9-A nrPDB 28 6.8 3DTC-A nrPDB 28 8.8 4CD4-A nrPDB 28 9.9 >6FAI-l nrPDB Length = 425 Score = 880 bits (2275), Expect = 0.0, Method: Compositional matrix adjust. Identities = 425/425 (100%), Positives = 425/425 (100%) Query: 1 MKLDTSHMRYLTTDDFRVLQAVEQGSRSHEVVPTPLIHQISGMRSQSGTNRAISDLAKLS 60 MKLDTSHMRYLTTDDFRVLQAVEQGSRSHEVVPTPLIHQISGMRSQSGTNRAISDLAKLS Sbjct: 1 MKLDTSHMRYLTTDDFRVLQAVEQGSRSHEVVPTPLIHQISGMRSQSGTNRAISDLAKLS 60 Query: 61 LISKMRNVKYDGYRLTYNGIDYLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPR 120 LISKMRNVKYDGYRLTYNGIDYLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPR Sbjct: 61 LISKMRNVKYDGYRLTYNGIDYLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPR 120 Query: 121 VMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEPF 180 VMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEPF Sbjct: 121 VMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEPF 180 Query: 181 DNSRHIVVMELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDK 240 DNSRHIVVMELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDK Sbjct: 181 DNSRHIVVMELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDK 240 Query: 241 LEDENDCGFVVIDFPQCISIQHQDADYYFQRDVDCIRRFFKKKLKYEPKPDSSMLDTEGF 300 LEDENDCGFVVIDFPQCISIQHQDADYYFQRDVDCIRRFFKKKLKYEPKPDSSMLDTEGF Sbjct: 241 LEDENDCGFVVIDFPQCISIQHQDADYYFQRDVDCIRRFFKKKLKYEPKPDSSMLDTEGF 300 Query: 301 GDGYKYAYPDFKRDVKRTDNLDELVQASGFSKKHPGDRGLETAVESMRNAVYNSDDDMSN 360 GDGYKYAYPDFKRDVKRTDNLDELVQASGFSKKHPGDRGLETAVESMRNAVYNSDDDMSN Sbjct: 301 GDGYKYAYPDFKRDVKRTDNLDELVQASGFSKKHPGDRGLETAVESMRNAVYNSDDDMSN 360 Query: 361 DEAEEENGEGDYSEEDEYYDSELDNESSEDDSEDAQEEENERIIEALSSGVENLKMDKLG 420 DEAEEENGEGDYSEEDEYYDSELDNESSEDDSEDAQEEENERIIEALSSGVENLKMDKLG Sbjct: 361 DEAEEENGEGDYSEEDEYYDSELDNESSEDDSEDAQEEENERIIEALSSGVENLKMDKLG 420 Query: 421 NYILE 425 NYILE Sbjct: 421 NYILE 425 >4GYG-A nrPDB Length = 397 Score = 340 bits (873), Expect = 5e-94, Method: Compositional matrix adjust. Identities = 173/354 (48%), Positives = 235/354 (66%), Gaps = 29/354 (8%) Query: 1 MKLDTSHMRYLTTDDFRVLQAVEQGSRSHEVVPTPLIHQISGMRS-QSGTNRAISDLAKL 59 MKLDT MR+LT +D+RVL AVE GS++HE+VPTPLI +I+ +R SG +++I+ LAK Sbjct: 2 MKLDTRAMRHLTAEDWRVLTAVEMGSKNHEIVPTPLIEKIARLRGGSSGVHKSIATLAKA 61 Query: 60 SLISKMRNVKYDGYRLTYNGIDYLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNP 119 LI++M+ KYDGYRLTY G+DYLAL T R VYSVG+ IGVGKESDI V+D+ G Sbjct: 62 GLIARMKEAKYDGYRLTYGGLDYLALHTHAARKDVYSVGSRIGVGKESDIMIVADEKGKQ 121 Query: 120 RVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEP 179 +V+KIHRLGR SF +V+ NRDYL+ + G +WM+LSRLAA KE+ FM LY +GF VPEP Sbjct: 122 KVLKIHRLGRISFRTVKANRDYLRNRSTG-SWMYLSRLAAIKEFAFMKALYEEGFPVPEP 180 Query: 180 FDNSRHIVVMELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKD 239 SRH +VM L++ PMR++ + LY+DL+ I+ LA GLIH DFNEFNI+I++ Sbjct: 181 IAQSRHTIVMSLVDALPMRQVSSVPDPASLYADLIALILRLAKHGLIHGDFNEFNILIRE 240 Query: 240 KLEDENDCGF----VVIDFPQCISIQHQDADYYFQRDVDCIRRFFKKKLKY---EPKPDS 292 + + E+ ++IDFPQ +S+ H +A+ YF RDV CI+RFF+++ + P P Sbjct: 241 EKDAEDPSSITLTPIIIDFPQMVSMDHPNAEMYFDRDVQCIKRFFERRFHFVSTTPGP-- 298 Query: 293 SMLDTEGFGDGYKYAYPDFKRDVKR--TDNLDELVQASGFSKKHPGDRGLETAV 344 Y D K+ V + LD ++ASGF+KK D LE A+ Sbjct: 299 --------------FYKDAKKTVGKDGAKRLDAALEASGFTKKMAKD--LEAAI 336 >6G18-v nrPDB Length = 552 Score = 296 bits (759), Expect = 8e-81, Method: Compositional matrix adjust. Identities = 165/396 (41%), Positives = 241/396 (60%), Gaps = 36/396 (9%) Query: 2 KLDTSHMRYLTTDDFRVLQAVEQGSRSHEVVPTPLIHQISGMRSQSGTNRAISDLAKLSL 61 K++ + +RY++ DDFRVL AVE G ++HE+VP LI I+ ++ G N+ + +L K L Sbjct: 3 KVNVAKLRYMSRDDFRVLTAVEMGMKNHEIVPGSLIASIASLK-HGGCNKVLRELVKHKL 61 Query: 62 ISKMRNVKYDGYRLTYNGIDYLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPRV 121 I+ R GYRLT G DYLALKT+ +R V SVGN +GVGKESDIY V+++ G Sbjct: 62 IAWERTKTVQGYRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESDIYIVANEEGQQFA 121 Query: 122 MKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEPFD 181 +K+HRLGRTSF +++N RDY K +W++LSRL+A KE+ +M LY + F VP+P D Sbjct: 122 LKLHRLGRTSFRNLKNKRDY-HKHRHNVSWLYLSRLSAMKEFAYMKALYERKFPVPKPID 180 Query: 182 NSRHIVVMELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKL 241 +RH VVMELI GYP+ ++ ++ +Y + M IV LAN GLIH DFNEFN+++ Sbjct: 181 YNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLANHGLIHGDFNEFNLIL---- 236 Query: 242 EDENDCGFVVIDFPQCISIQHQDADYYFQRDVDCIRRFFKKKLKYEPKPDSSMLDTEGFG 301 DE+D +IDFPQ +S H +A++YF RDV CI+ FF K+ YE + Sbjct: 237 -DESD-HITMIDFPQMVSTSHPNAEWYFDRDVKCIKDFFMKRFSYESE------------ 282 Query: 302 DGYKYAYPDFKRDVKRTDNLDELVQASGFSKKHPGDRGLETAVESMRNAVYNSDDDMSND 361 +P FK D++R D LD V ASG++K+ D + + + + D ++ Sbjct: 283 -----LFPTFK-DIRREDTLDVEVSASGYTKEMQAD-------DELLHPLGPDDKNIETK 329 Query: 362 EAEEEN-GEGDYSEEDEYYDSELDNESSEDDSEDAQ 396 E E + +G+ +E+ E Y SE NES + E+++ Sbjct: 330 EGSEFSFSDGEVAEKAEVYGSE--NESERNCLEESE 363 >6FDN-A nrPDB Length = 320 Score = 291 bits (744), Expect = 5e-79, Method: Compositional matrix adjust. Identities = 152/336 (45%), Positives = 213/336 (63%), Gaps = 26/336 (7%) Query: 2 KLDTSHMRYLTTDDFRVLQAVEQGSRSHEVVPTPLIHQISGMRSQSGTNRAISDLAKLSL 61 K++ + +RY++ DDFRVL AVE G ++HE+VP LI I+ ++ G N+ + +L K L Sbjct: 3 KVNVAKLRYMSRDDFRVLTAVEMGMKNHEIVPGSLIASIASLK-HGGCNKVLRELVKHKL 61 Query: 62 ISKMRNVKYDGYRLTYNGIDYLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPRV 121 I+ R GYRLT G DYLALKT+ +R V SVGN +GVGKESDIY V+++ G Sbjct: 62 IAWERTKTVQGYRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESDIYIVANEEGQQFA 121 Query: 122 MKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEPFD 181 +K+HRLGRTSF +++N RDY K +W++LSRL+A KE+ +M LY + F VP+P D Sbjct: 122 LKLHRLGRTSFRNLKNKRDY-HKHRHNVSWLYLSRLSAMKEFAYMKALYERKFPVPKPID 180 Query: 182 NSRHIVVMELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKL 241 +RH VVMELI GYP+ ++ ++ +Y + M IV LAN GLIH DFNEFN+++ Sbjct: 181 YNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLANHGLIHGDFNEFNLIL---- 236 Query: 242 EDENDCGFVVIDFPQCISIQHQDADYYFQRDVDCIRRFFKKKLKYEPKPDSSMLDTEGFG 301 DE+D +IDFPQ +S H +A++YF RDV CI+ FF K+ YE + Sbjct: 237 -DESD-HITMIDFPQMVSTSHPNAEWYFDRDVKCIKDFFMKRFSYESE------------ 282 Query: 302 DGYKYAYPDFKRDVKRTDNLDELVQASGFSKKHPGD 337 +P FK D++R D LD V ASG++K+ D Sbjct: 283 -----LFPTFK-DIRREDTLDVEVSASGYTKEMQAD 312 >1TQM-A nrPDB Length = 282 Score = 98.6 bits (244), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 71/284 (25%), Positives = 137/284 (48%), Gaps = 27/284 (9%) Query: 16 FRVLQAVEQGSRSHEVVPTPLI--HQISGMRSQSGTNRAISDLAKLSLISKMRNVKYDGY 73 +R++ A+ + +E VP LI H G + +SDL + + R Y+G Sbjct: 15 WRIMDAIFKNLWDYEYVPLQLISSHARIGEEKARNILKYLSDLR----VVQNRQKDYEGS 70 Query: 74 RLTYNGIDYLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPRVMKIHRLGRTSFH 133 T+ G+ +L ++ V ++G +G GKES ++ + V+K H++G TSF Sbjct: 71 TFTFIGLSLYSLHRLVRSGKVDAIGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSFK 130 Query: 134 SVRNNRDYLKKSNQGANWMHLSRLA---ANKEYQFMSMLYSKGFKVPEPFDNSRHIVVME 190 V+ RDY +H S LA A E++ + L +G VP+ + + V+ME Sbjct: 131 KVKEKRDYGD--------LHFSVLAIRSARNEFRALQKL--QGLAVPKVYAWEGNAVLME 180 Query: 191 LIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFV 250 LI+ + R+R +N ++ ++ + + G++H D +++N+++ ++ G Sbjct: 181 LIDAKELYRVRV-ENPDEVLDMILEEVAKFYHRGIVHGDLSQYNVLVSEE-------GIW 232 Query: 251 VIDFPQCISIQHQDADYYFQRDVDCIRRFFKKKLKYEPKPDSSM 294 +IDFPQ + + + +RDV I +F + + E +S++ Sbjct: 233 IIDFPQSVEVGEEGWREILERDVRNIITYFSRTYRTEKDINSAI 276 >1ZP9-A nrPDB Length = 258 Score = 64.7 bits (156), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 64/256 (25%), Positives = 120/256 (46%), Gaps = 41/256 (16%) Query: 53 ISDLAKL-SLISKMRNVKYDG--YRLTYNGIDYLALKTMLN---RDTVYSVGNTIGVGKE 106 + DL K+ S + K+R + DG ++ +D LKT+ + + ++G I GKE Sbjct: 1 MKDLKKIESYLDKLRIKEKDGEERKIYAEVLDGRTLKTLYKLSAKGYITAMGGVISTGKE 60 Query: 107 SDIYKVSDK-NGNPRVM--KIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLA----- 158 ++++ +G P M KI+R+ + F D + + G + R++ Sbjct: 61 ANVFYADGVFDGKPVAMAVKIYRIETSEF-------DKMDEYLYGDERFDMRRISPKEKV 113 Query: 159 ---ANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELI--EGYP------MRRLRKHKNIP 207 KE++ + G VP+P+ +++++ME I + P + R K ++ Sbjct: 114 FIWTEKEFRNLERAKEAGVSVPQPYTYMKNVLLMEFIGEDELPAPTLVELGRELKELDVE 173 Query: 208 KLYSDLMCFIVDLANSG-LIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQHQDAD 266 +++D++ + L L+H D +E+NIM DK+ ID Q ++++H A+ Sbjct: 174 GIFNDVVENVKRLYQEAELVHADLSEYNIMYIDKV--------YFIDMGQAVTLRHPMAE 225 Query: 267 YYFQRDVDCIRRFFKK 282 Y +RDV I RFF K Sbjct: 226 SYLERDVRNIIRFFSK 241 >6G5I-z nrPDB Length = 568 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 50/211 (23%), Positives = 91/211 (43%), Gaps = 23/211 (10%) Query: 83 LALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPRVMKIHRLGRTSFHSVRNNRDYL 142 + L ML R + + I GKE+++Y S NG R +KI+ +TS ++ Y+ Sbjct: 168 MILFKMLTRGIITEINGCISTGKEANVYHASTANGESRAIKIY---KTSILVFKDRDKYV 224 Query: 143 K---KSNQG---ANWMHLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELI--EG 194 + G N + + A KE + + L + PEP H++VM I + Sbjct: 225 SGEFRFRHGYCKGNPRKMVKTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDD 284 Query: 195 YPMRRLR----KHKNIPKLYSDLMCFIVDL-ANSGLIHCDFNEFNIMIKDKLEDENDCGF 249 P L+ +LY ++ ++ + ++ L+H D +EFN++ + G Sbjct: 285 MPAPLLKNVQLSESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLY-------HGGGV 337 Query: 250 VVIDFPQCISIQHQDADYYFQRDVDCIRRFF 280 +ID Q + H A + ++D + FF Sbjct: 338 YIIDVSQSVEHDHPHALEFLRKDCANVNDFF 368 >4OTP-A nrPDB Length = 352 Score = 57.8 bits (138), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 50/213 (23%), Positives = 92/213 (43%), Gaps = 23/213 (10%) Query: 83 LALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPRVMKIHRLGRTSFHSVRNNRDYL 142 + L ML R + + I GKE+++Y S NG R +KI+ +TS ++ Y+ Sbjct: 26 MILFKMLTRGIITEINGCISTGKEANVYHASTANGESRAIKIY---KTSILVFKDRDKYV 82 Query: 143 K---KSNQG---ANWMHLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELI--EG 194 + G N + + A KE + + L + PEP H++VM I + Sbjct: 83 SGEFRFRHGYCKGNPRKMVKTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDD 142 Query: 195 YPMRRLR----KHKNIPKLYSDLMCFIVDL-ANSGLIHCDFNEFNIMIKDKLEDENDCGF 249 P L+ +LY ++ ++ + ++ L+H D +EFN++ + G Sbjct: 143 MPAPLLKNVQLSESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLY-------HGGGV 195 Query: 250 VVIDFPQCISIQHQDADYYFQRDVDCIRRFFKK 282 +ID Q + H A + ++D + FF + Sbjct: 196 YIIDVSQSVEHDHPHALEFLRKDCANVNDFFMR 228 >2XS0-A nrPDB Length = 386 Score = 34.7 bits (78), Expect = 0.086, Method: Compositional matrix adjust. Identities = 20/71 (28%), Positives = 38/71 (53%), Gaps = 9/71 (12%) Query: 187 VVMELIEGYPMRRLRK---HKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLED 243 +VMEL++ + ++ H+ + L ++C I L ++G+IH D NI++K Sbjct: 108 IVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK----- 162 Query: 244 ENDCGFVVIDF 254 +DC ++DF Sbjct: 163 -SDCTLKILDF 172 >1JNK-A nrPDB Length = 423 Score = 33.5 bits (75), Expect = 0.17, Method: Compositional matrix adjust. Identities = 20/71 (28%), Positives = 38/71 (53%), Gaps = 9/71 (12%) Query: 187 VVMELIEGYPMRRLRK---HKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLED 243 +VMEL++ + ++ H+ + L ++C I L ++G+IH D NI++K Sbjct: 144 LVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK----- 198 Query: 244 ENDCGFVVIDF 254 +DC ++DF Sbjct: 199 -SDCTLKILDF 208 >3FI2-A nrPDB Length = 353 Score = 33.5 bits (75), Expect = 0.19, Method: Compositional matrix adjust. Identities = 20/71 (28%), Positives = 38/71 (53%), Gaps = 9/71 (12%) Query: 187 VVMELIEGYPMRRLRK---HKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLED 243 +VMEL++ + ++ H+ + L ++C I L ++G+IH D NI++K Sbjct: 106 LVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK----- 160 Query: 244 ENDCGFVVIDF 254 +DC ++DF Sbjct: 161 -SDCTLKILDF 170 >3E7O-A nrPDB Length = 360 Score = 33.5 bits (75), Expect = 0.19, Method: Compositional matrix adjust. Identities = 20/71 (28%), Positives = 37/71 (52%), Gaps = 9/71 (12%) Query: 187 VVMELIEGYPMRRLRK---HKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLED 243 +VMEL++ + + H+ + L ++C I L ++G+IH D NI++K Sbjct: 104 LVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK----- 158 Query: 244 ENDCGFVVIDF 254 +DC ++DF Sbjct: 159 -SDCTLKILDF 168 >5AWM-A nrPDB Length = 394 Score = 33.5 bits (75), Expect = 0.20, Method: Compositional matrix adjust. Identities = 31/123 (25%), Positives = 55/123 (44%), Gaps = 19/123 (15%) Query: 143 KKSNQGANWMHLSRLAANKEYQFMSMLYSKGF-KVPEPFDNSRHI-------VVMELIEG 194 K S N H R A +E++ M ++ K + F R++ +VMEL++ Sbjct: 76 KLSRPFQNVTHAKR--AYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA 133 Query: 195 YPMRRLRK---HKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVV 251 + ++ H + L ++C I L ++G+IH D NI++K DC + Sbjct: 134 NLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKA------DCTLKI 187 Query: 252 IDF 254 +DF Sbjct: 188 LDF 190 >5YK0-A nrPDB Length = 452 Score = 32.3 bits (72), Expect = 0.36, Method: Compositional matrix adjust. Identities = 20/68 (29%), Positives = 33/68 (48%), Gaps = 4/68 (5%) Query: 174 FKVPEPFDNSRHIVVMELIEGYPMRRLRKHKNIPK--LYSDLMCFIVDLANS--GLIHCD 229 F+VP ++ +V+ E IEG PM + +H + L L+ + A GL+H D Sbjct: 232 FQVPHVVASAPKVVIQEWIEGVPMAEIIRHGTTEQRDLIGTLLAELTFDAPRRLGLMHGD 291 Query: 230 FNEFNIMI 237 + N M+ Sbjct: 292 AHPGNFML 299 >2YCR-A nrPDB Length = 323 Score = 30.8 bits (68), Expect = 1.1, Method: Compositional matrix adjust. Identities = 26/89 (29%), Positives = 42/89 (47%), Gaps = 13/89 (14%) Query: 174 FKVPEPFDNSRHIVVMELIEGYPM-------RRLRKHKNIPKLYSDLMCFIVD-LANSGL 225 K+ FD + +V+EL+EG + +RL++ KLY M V L +G+ Sbjct: 78 IKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATC--KLYFYQMLLAVQYLHENGI 135 Query: 226 IHCDFNEFNIMIKDKLEDENDCGFVVIDF 254 IH D N+++ + E DC + DF Sbjct: 136 IHRDLKPENVLLSSQ---EEDCLIKITDF 161 >3I6U-A nrPDB Length = 419 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 26/89 (29%), Positives = 42/89 (47%), Gaps = 13/89 (14%) Query: 174 FKVPEPFDNSRHIVVMELIEGYPM-------RRLRKHKNIPKLYSDLMCFIVD-LANSGL 225 K+ FD + +V+EL+EG + +RL++ KLY M V L +G+ Sbjct: 203 IKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATC--KLYFYQMLLAVQYLHENGI 260 Query: 226 IHCDFNEFNIMIKDKLEDENDCGFVVIDF 254 IH D N+++ + E DC + DF Sbjct: 261 IHRDLKPENVLLSSQ---EEDCLIKITDF 286 >3OMV-A nrPDB Length = 307 Score = 29.6 bits (65), Expect = 2.8, Method: Compositional matrix adjust. Identities = 37/156 (23%), Positives = 62/156 (39%), Gaps = 27/156 (17%) Query: 71 DGYRLTYNGIDYLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPRVMKIHRLGRT 130 D R T G+DYL K +++RD K ++I+ +KI G Sbjct: 136 DIARQTAQGMDYLHAKNIIHRDM-----------KSNNIFLHEGLT-----VKIGDFGLA 179 Query: 131 SFHSVRNNRDYLKKSNQGANWM--HLSRLAANKEYQFMSMLYSKGF--------KVPEPF 180 + S + +++ WM + R+ N + F S +YS G ++P Sbjct: 180 TVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSH 239 Query: 181 DNSRHIVVMELIEGYPMRRLRK-HKNIPKLYSDLMC 215 N+R ++ + GY L K +KN PK L+ Sbjct: 240 INNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVA 275 >5ZTN-A nrPDB Length = 429 Score = 28.9 bits (63), Expect = 4.2, Method: Compositional matrix adjust. Identities = 42/183 (22%), Positives = 74/183 (40%), Gaps = 27/183 (14%) Query: 95 YSVGNTIGVGKESDIYKVSDKNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWM-H 153 Y V IG G + K D K+H+ + VRN + + +++ + + H Sbjct: 99 YEVLKVIGKGSFGQVVKAYDH-------KVHQ--HVALKMVRNEKRFHRQAAEEIRILEH 149 Query: 154 LSRLAANKEYQFMSMLYSKGFK--VPEPFD----NSRHIVVMELIEGYPMRRLRKHKNIP 207 L + + + ML + F+ + F+ N ++ +G+ + +RK Sbjct: 150 LRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFA--- 206 Query: 208 KLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQHQDADY 267 +S L C + L + +IHCD NI++K + G VIDF +HQ Sbjct: 207 --HSILQC-LDALHKNRIIHCDLKPENILLK----QQGRSGIKVIDFGSS-CYEHQRVYT 258 Query: 268 YFQ 270 Y Q Sbjct: 259 YIQ 261 >4UY9-A nrPDB Length = 323 Score = 28.1 bits (61), Expect = 6.8, Method: Compositional matrix adjust. Identities = 20/65 (30%), Positives = 30/65 (46%), Gaps = 8/65 (12%) Query: 187 VVMELIEGYPMRRLRKHKNIPK--------LYSDLMCFIVDLANSGLIHCDFNEFNIMIK 238 +VME G P+ R+ K IP + M ++ D A +IH D NI+I Sbjct: 85 LVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILIL 144 Query: 239 DKLED 243 K+E+ Sbjct: 145 QKVEN 149 >3DTC-A nrPDB Length = 271 Score = 27.7 bits (60), Expect = 8.8, Method: Compositional matrix adjust. Identities = 20/65 (30%), Positives = 30/65 (46%), Gaps = 8/65 (12%) Query: 187 VVMELIEGYPMRRLRKHKNIPK--------LYSDLMCFIVDLANSGLIHCDFNEFNIMIK 238 +VME G P+ R+ K IP + M ++ D A +IH D NI+I Sbjct: 83 LVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILIL 142 Query: 239 DKLED 243 K+E+ Sbjct: 143 QKVEN 147 >4CD4-A nrPDB Length = 419 Score = 27.7 bits (60), Expect = 9.9, Method: Compositional matrix adjust. Identities = 16/40 (40%), Positives = 19/40 (47%), Gaps = 1/40 (2%) Query: 282 KKLKYEPKPDSSMLDTEGFGDGYKYAYP-DFKRDVKRTDN 320 + L Y PD S +D F GY Y YP D D+ DN Sbjct: 257 RNLIYAYSPDRSRIDMANFEAGYLYGYPGDAYVDIIGLDN 296 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6FAI-l nrPDB 614 e-176 6G18-v nrPDB 497 e-141 6FDN-A nrPDB 452 e-127 4GYG-A nrPDB 428 e-120 1TQM-A nrPDB 306 1e-83 4OTP-A nrPDB 213 1e-55 1ZP9-A nrPDB 209 2e-54 6G5I-z nrPDB 206 1e-53 Sequences not found previously or not previously below threshold: 5AP3-A nrPDB 50 2e-06 6GVJ-A nrPDB 49 6e-06 3HMP-A nrPDB 46 2e-05 2ZMD-A nrPDB 46 3e-05 3ENH-A nrPDB 44 1e-04 4IDT-A nrPDB 44 2e-04 2JAM-A nrPDB 41 7e-04 5U6Y-A nrPDB 41 9e-04 2VZ6-A nrPDB 41 9e-04 4C0T-A nrPDB 41 0.001 3MA6-A nrPDB 41 0.001 2V7O-A nrPDB 40 0.002 5FG8-A nrPDB 40 0.002 3DFA-A nrPDB 39 0.003 3ORP-A nrPDB 39 0.003 3E7O-A nrPDB 39 0.004 5JN2-A nrPDB 39 0.005 3LM0-A nrPDB 39 0.006 4G3E-A nrPDB 38 0.006 3BHH-A nrPDB 38 0.007 3SOA-A nrPDB 38 0.007 3NCG-A nrPDB 38 0.007 2BDW-A nrPDB 38 0.007 5ZTN-A nrPDB 38 0.007 1JNK-A nrPDB 38 0.010 4JLC-A nrPDB 37 0.010 2XS0-A nrPDB 37 0.010 3FI2-A nrPDB 37 0.011 2A27-A nrPDB 37 0.013 3DXN-A nrPDB 37 0.014 2W4O-A nrPDB 37 0.014 1ZWS-A nrPDB 37 0.015 3GUB-A nrPDB 37 0.018 5D7A-A nrPDB 37 0.019 1PHK-A nrPDB 37 0.019 5AWM-A nrPDB 37 0.020 4D28-A nrPDB 36 0.024 4YZB-A nrPDB 36 0.026 3HZT-A nrPDB 36 0.029 3KN6-A nrPDB 36 0.031 1U5R-A nrPDB 36 0.033 5YK0-A nrPDB 36 0.033 2VN9-A nrPDB 36 0.038 6O8B-A nrPDB 36 0.039 3I6U-A nrPDB 35 0.060 2PZI-A nrPDB 35 0.064 4JG6-A nrPDB 35 0.065 2YAB-A nrPDB 35 0.066 2YCR-A nrPDB 35 0.068 4Y12-A nrPDB 35 0.082 4FG9-A nrPDB 34 0.086 3KK8-A nrPDB 34 0.090 2JC6-A nrPDB 34 0.11 3MN3-A nrPDB 34 0.11 5Y86-A nrPDB 34 0.14 4AZW-A nrPDB 34 0.14 2CMW-A nrPDB 34 0.14 4BVU-A nrPDB 34 0.15 4AZV-A nrPDB 34 0.17 2J90-A nrPDB 34 0.18 4WNO-A nrPDB 34 0.19 5TUR-A nrPDB 33 0.20 4RC3-A nrPDB 33 0.20 3BGP-A nrPDB 33 0.20 2Y7J-A nrPDB 33 0.22 4CZT-A nrPDB 33 0.24 3LIJ-A nrPDB 33 0.28 5CLR-A nrPDB 33 0.31 2OC2-A nrPDB 32 0.34 5YV8-A nrPDB 32 0.34 4NIF-A nrPDB 32 0.35 5XZW-A nrPDB 32 0.36 4PXI-A nrPDB 32 0.37 2GCD-A nrPDB 32 0.37 4UY9-A nrPDB 32 0.38 3DTC-A nrPDB 32 0.38 6CMJ-A nrPDB 32 0.40 5TQX-A nrPDB 32 0.41 4U41-A nrPDB 32 0.42 4JXF-A nrPDB 32 0.44 4RGJ-A nrPDB 32 0.47 3ZDU-A nrPDB 32 0.53 5IG1-A nrPDB 32 0.56 3DAK-A nrPDB 32 0.68 3VHK-A nrPDB 31 0.73 1UA2-A nrPDB 31 0.84 2W1Z-A nrPDB 31 0.87 5U0A-N nrPDB 31 1.0 4KIK-B nrPDB 31 1.2 3IS5-A nrPDB 31 1.2 4IVN-A nrPDB 31 1.3 4EPA-A nrPDB 31 1.3 1V0B-A nrPDB 30 1.8 3H4J-B nrPDB 30 2.1 2RIO-A nrPDB 30 2.5 3Q5I-A nrPDB 30 2.5 6QAU-A nrPDB 30 2.5 6HMD-A nrPDB 30 2.5 2BRG-A nrPDB 29 2.8 1U59-A nrPDB 29 2.9 6CCF-A nrPDB 29 3.1 1KOB-A nrPDB 29 3.3 3J6B-S nrPDB 29 3.4 5M07-A nrPDB 29 3.5 5WLC-LS nrPDB 29 3.7 6I9E-A nrPDB 29 4.4 5JZN-A nrPDB 29 5.4 4NEU-A nrPDB 28 6.2 5EW5-A nrPDB 28 6.6 4GVP-A nrPDB 28 9.8 >6FAI-l nrPDB Length = 425 Score = 614 bits (1583), Expect = e-176, Method: Composition-based stats. Identities = 425/425 (100%), Positives = 425/425 (100%) Query: 1 MKLDTSHMRYLTTDDFRVLQAVEQGSRSHEVVPTPLIHQISGMRSQSGTNRAISDLAKLS 60 MKLDTSHMRYLTTDDFRVLQAVEQGSRSHEVVPTPLIHQISGMRSQSGTNRAISDLAKLS Sbjct: 1 MKLDTSHMRYLTTDDFRVLQAVEQGSRSHEVVPTPLIHQISGMRSQSGTNRAISDLAKLS 60 Query: 61 LISKMRNVKYDGYRLTYNGIDYLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPR 120 LISKMRNVKYDGYRLTYNGIDYLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPR Sbjct: 61 LISKMRNVKYDGYRLTYNGIDYLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPR 120 Query: 121 VMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEPF 180 VMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEPF Sbjct: 121 VMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEPF 180 Query: 181 DNSRHIVVMELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDK 240 DNSRHIVVMELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDK Sbjct: 181 DNSRHIVVMELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDK 240 Query: 241 LEDENDCGFVVIDFPQCISIQHQDADYYFQRDVDCIRRFFKKKLKYEPKPDSSMLDTEGF 300 LEDENDCGFVVIDFPQCISIQHQDADYYFQRDVDCIRRFFKKKLKYEPKPDSSMLDTEGF Sbjct: 241 LEDENDCGFVVIDFPQCISIQHQDADYYFQRDVDCIRRFFKKKLKYEPKPDSSMLDTEGF 300 Query: 301 GDGYKYAYPDFKRDVKRTDNLDELVQASGFSKKHPGDRGLETAVESMRNAVYNSDDDMSN 360 GDGYKYAYPDFKRDVKRTDNLDELVQASGFSKKHPGDRGLETAVESMRNAVYNSDDDMSN Sbjct: 301 GDGYKYAYPDFKRDVKRTDNLDELVQASGFSKKHPGDRGLETAVESMRNAVYNSDDDMSN 360 Query: 361 DEAEEENGEGDYSEEDEYYDSELDNESSEDDSEDAQEEENERIIEALSSGVENLKMDKLG 420 DEAEEENGEGDYSEEDEYYDSELDNESSEDDSEDAQEEENERIIEALSSGVENLKMDKLG Sbjct: 361 DEAEEENGEGDYSEEDEYYDSELDNESSEDDSEDAQEEENERIIEALSSGVENLKMDKLG 420 Query: 421 NYILE 425 NYILE Sbjct: 421 NYILE 425 >6G18-v nrPDB Length = 552 Score = 497 bits (1278), Expect = e-141, Method: Composition-based stats. Identities = 162/396 (40%), Positives = 238/396 (60%), Gaps = 36/396 (9%) Query: 2 KLDTSHMRYLTTDDFRVLQAVEQGSRSHEVVPTPLIHQISGMRSQSGTNRAISDLAKLSL 61 K++ + +RY++ DDFRVL AVE G ++HE+VP LI I+ ++ G N+ + +L K L Sbjct: 3 KVNVAKLRYMSRDDFRVLTAVEMGMKNHEIVPGSLIASIASLK-HGGCNKVLRELVKHKL 61 Query: 62 ISKMRNVKYDGYRLTYNGIDYLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPRV 121 I+ R GYRLT G DYLALKT+ +R V SVGN +GVGKESDIY V+++ G Sbjct: 62 IAWERTKTVQGYRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESDIYIVANEEGQQFA 121 Query: 122 MKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEPFD 181 +K+HRLGRTSF +++N RDY K +W++LSRL+A KE+ +M LY + F VP+P D Sbjct: 122 LKLHRLGRTSFRNLKNKRDY-HKHRHNVSWLYLSRLSAMKEFAYMKALYERKFPVPKPID 180 Query: 182 NSRHIVVMELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKL 241 +RH VVMELI GYP+ ++ ++ +Y + M IV LAN GLIH DFNEFN+++ + Sbjct: 181 YNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLANHGLIHGDFNEFNLILDES- 239 Query: 242 EDENDCGFVVIDFPQCISIQHQDADYYFQRDVDCIRRFFKKKLKYEPKPDSSMLDTEGFG 301 +IDFPQ +S H +A++YF RDV CI+ FF K+ YE + Sbjct: 240 -----DHITMIDFPQMVSTSHPNAEWYFDRDVKCIKDFFMKRFSYESE------------ 282 Query: 302 DGYKYAYPDFKRDVKRTDNLDELVQASGFSKKHPGDRGLETAVESMRNAVYNSDDDMSND 361 +P FK D++R D LD V ASG++K+ D + + + + D ++ Sbjct: 283 -----LFPTFK-DIRREDTLDVEVSASGYTKEMQAD-------DELLHPLGPDDKNIETK 329 Query: 362 EAEEEN-GEGDYSEEDEYYDSELDNESSEDDSEDAQ 396 E E + +G+ +E+ E Y SE NES + E+++ Sbjct: 330 EGSEFSFSDGEVAEKAEVYGSE--NESERNCLEESE 363 >6FDN-A nrPDB Length = 320 Score = 452 bits (1163), Expect = e-127, Method: Composition-based stats. Identities = 149/351 (42%), Positives = 214/351 (60%), Gaps = 33/351 (9%) Query: 2 KLDTSHMRYLTTDDFRVLQAVEQGSRSHEVVPTPLIHQISGMRSQSGTNRAISDLAKLSL 61 K++ + +RY++ DDFRVL AVE G ++HE+VP LI I+ ++ G N+ + +L K L Sbjct: 3 KVNVAKLRYMSRDDFRVLTAVEMGMKNHEIVPGSLIASIASLK-HGGCNKVLRELVKHKL 61 Query: 62 ISKMRNVKYDGYRLTYNGIDYLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPRV 121 I+ R GYRLT G DYLALKT+ +R V SVGN +GVGKESDIY V+++ G Sbjct: 62 IAWERTKTVQGYRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESDIYIVANEEGQQFA 121 Query: 122 MKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEPFD 181 +K+HRLGRTSF +++N RDY K +W++LSRL+A KE+ +M LY + F VP+P D Sbjct: 122 LKLHRLGRTSFRNLKNKRDY-HKHRHNVSWLYLSRLSAMKEFAYMKALYERKFPVPKPID 180 Query: 182 NSRHIVVMELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKL 241 +RH VVMELI GYP+ ++ ++ +Y + M IV LAN GLIH DFNEFN+++ + Sbjct: 181 YNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLANHGLIHGDFNEFNLILDES- 239 Query: 242 EDENDCGFVVIDFPQCISIQHQDADYYFQRDVDCIRRFFKKKLKYEPKPDSSMLDTEGFG 301 +IDFPQ +S H +A++YF RDV CI+ FF K+ YE + Sbjct: 240 -----DHITMIDFPQMVSTSHPNAEWYFDRDVKCIKDFFMKRFSYESE------------ 282 Query: 302 DGYKYAYPDFKRDVKRTDNLDELVQASGFSKKHPGDRGLETAVESMRNAVY 352 +P FK D++R D LD V ASG++K+ D + + + + Sbjct: 283 -----LFPTFK-DIRREDTLDVEVSASGYTKEMQAD-------DELLHPLG 320 >4GYG-A nrPDB Length = 397 Score = 428 bits (1101), Expect = e-120, Method: Composition-based stats. Identities = 171/353 (48%), Positives = 232/353 (65%), Gaps = 23/353 (6%) Query: 1 MKLDTSHMRYLTTDDFRVLQAVEQGSRSHEVVPTPLIHQISGMRS-QSGTNRAISDLAKL 59 MKLDT MR+LT +D+RVL AVE GS++HE+VPTPLI +I+ +R SG +++I+ LAK Sbjct: 2 MKLDTRAMRHLTAEDWRVLTAVEMGSKNHEIVPTPLIEKIARLRGGSSGVHKSIATLAKA 61 Query: 60 SLISKMRNVKYDGYRLTYNGIDYLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNP 119 LI++M+ KYDGYRLTY G+DYLAL T R VYSVG+ IGVGKESDI V+D+ G Sbjct: 62 GLIARMKEAKYDGYRLTYGGLDYLALHTHAARKDVYSVGSRIGVGKESDIMIVADEKGKQ 121 Query: 120 RVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEP 179 +V+KIHRLGR SF +V+ NRDYL+ + G +WM+LSRLAA KE+ FM LY +GF VPEP Sbjct: 122 KVLKIHRLGRISFRTVKANRDYLRNRSTG-SWMYLSRLAAIKEFAFMKALYEEGFPVPEP 180 Query: 180 FDNSRHIVVMELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKD 239 SRH +VM L++ PMR++ + LY+DL+ I+ LA GLIH DFNEFNI+I++ Sbjct: 181 IAQSRHTIVMSLVDALPMRQVSSVPDPASLYADLIALILRLAKHGLIHGDFNEFNILIRE 240 Query: 240 KLEDENDCGFV----VIDFPQCISIQHQDADYYFQRDVDCIRRFFKKKLKYEPKPDSSML 295 + + E+ +IDFPQ +S+ H +A+ YF RDV CI+RFF+++ + Sbjct: 241 EKDAEDPSSITLTPIIIDFPQMVSMDHPNAEMYFDRDVQCIKRFFERRFHFVS------- 293 Query: 296 DTEGFGDGYKYAYPDFKRDVKR--TDNLDELVQASGFSKKHPGDRGLETAVES 346 Y D K+ V + LD ++ASGF+KK D LE A+ Sbjct: 294 ------TTPGPFYKDAKKTVGKDGAKRLDAALEASGFTKKMAKD--LEAAIRE 338 >1TQM-A nrPDB Length = 282 Score = 306 bits (784), Expect = 1e-83, Method: Composition-based stats. Identities = 71/289 (24%), Positives = 138/289 (47%), Gaps = 27/289 (9%) Query: 11 LTTDDFRVLQAVEQGSRSHEVVPTPLI--HQISGMRSQSGTNRAISDLAKLSLISKMRNV 68 + +R++ A+ + +E VP LI H G + +SDL + + R Sbjct: 10 MGKHSWRIMDAIFKNLWDYEYVPLQLISSHARIGEEKARNILKYLSDLR----VVQNRQK 65 Query: 69 KYDGYRLTYNGIDYLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPRVMKIHRLG 128 Y+G T+ G+ +L ++ V ++G +G GKES ++ + V+K H++G Sbjct: 66 DYEGSTFTFIGLSLYSLHRLVRSGKVDAIGKLMGEGKESAVFNCYSEKFGECVVKFHKVG 125 Query: 129 RTSFHSVRNNRDYLKKSNQGANWMHLSRLA---ANKEYQFMSMLYSKGFKVPEPFDNSRH 185 TSF V+ RDY +H S LA A E++ + L +G VP+ + + Sbjct: 126 HTSFKKVKEKRDYGD--------LHFSVLAIRSARNEFRALQKL--QGLAVPKVYAWEGN 175 Query: 186 IVVMELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDEN 245 V+MELI+ + R+R +N ++ ++ + + G++H D +++N+++ ++ Sbjct: 176 AVLMELIDAKELYRVR-VENPDEVLDMILEEVAKFYHRGIVHGDLSQYNVLVSEE----- 229 Query: 246 DCGFVVIDFPQCISIQHQDADYYFQRDVDCIRRFFKKKLKYEPKPDSSM 294 G +IDFPQ + + + +RDV I +F + + E +S++ Sbjct: 230 --GIWIIDFPQSVEVGEEGWREILERDVRNIITYFSRTYRTEKDINSAI 276 >4OTP-A nrPDB Length = 352 Score = 213 bits (541), Expect = 1e-55, Method: Composition-based stats. Identities = 63/327 (19%), Positives = 124/327 (37%), Gaps = 44/327 (13%) Query: 66 RNVKYDGYRLTYNGID---YLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPRVM 122 R +D + L ML R + + I GKE+++Y S NG R + Sbjct: 6 RIKDKADRATVEQVLDPRTRMILFKMLTRGIITEINGCISTGKEANVYHASTANGESRAI 65 Query: 123 KIHRLGRTSFHSVRNNRDYLK---KSNQG---ANWMHLSRLAANKEYQFMSMLYSKGFKV 176 KI++ TS ++ Y+ + G N + + A KE + + L + Sbjct: 66 KIYK---TSILVFKDRDKYVSGEFRFRHGYCKGNPRKMVKTWAEKEMRNLIRLNTAEIPC 122 Query: 177 PEPFDNSRHIVVMELI--EGYPMRRLR----KHKNIPKLYSDLMCFIVDLA-NSGLIHCD 229 PEP H++VM I + P L+ +LY ++ ++ + ++ L+H D Sbjct: 123 PEPIMLRSHVLVMSFIGKDDMPAPLLKNVQLSESKARELYLQVIQYMRRMYQDARLVHAD 182 Query: 230 FNEFNIMIKDKLEDENDCGFVVIDFPQCISIQHQDADYYFQRDVDCIRRFFKKK------ 283 +EFN++ + G +ID Q + H A + ++D + FF + Sbjct: 183 LSEFNMLY-------HGGGVYIIDVSQSVEHDHPHALEFLRKDCANVNDFFMRHSVAVMT 235 Query: 284 ----LKYEPKPDSSMLDTEGF-GDGYKYAYPDFKRDVKRTDNLDELVQASGF-------S 331 ++ P + + + + + A K + D++DE V + Sbjct: 236 VRELFEFVTDPSITHENMDAYLSKAMEIASQRTKEERSSQDHVDEEVFKRAYIPRTLNEV 295 Query: 332 KKHPGDRGLETAVESMRNAVYNSDDDM 358 K + D + ++ A+ D++ Sbjct: 296 KNYERDMDIIMKLKEEDMAMNAQQDNI 322 >1ZP9-A nrPDB Length = 258 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 64/256 (25%), Positives = 118/256 (46%), Gaps = 41/256 (16%) Query: 53 ISDLAKL-SLISKMRNVKYDG--YRLTYNGIDYLALKTMLN---RDTVYSVGNTIGVGKE 106 + DL K+ S + K+R + DG ++ +D LKT+ + + ++G I GKE Sbjct: 1 MKDLKKIESYLDKLRIKEKDGEERKIYAEVLDGRTLKTLYKLSAKGYITAMGGVISTGKE 60 Query: 107 SDIYKVSDK-NGNPRVM--KIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRL------ 157 ++++ +G P M KI+R+ + F D + + G + R+ Sbjct: 61 ANVFYADGVFDGKPVAMAVKIYRIETSEF-------DKMDEYLYGDERFDMRRISPKEKV 113 Query: 158 --AANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELI--EGYP------MRRLRKHKNIP 207 KE++ + G VP+P+ +++++ME I + P + R K ++ Sbjct: 114 FIWTEKEFRNLERAKEAGVSVPQPYTYMKNVLLMEFIGEDELPAPTLVELGRELKELDVE 173 Query: 208 KLYSDLMCFIVDLANSG-LIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQHQDAD 266 +++D++ + L L+H D +E+NIM DK ID Q ++++H A+ Sbjct: 174 GIFNDVVENVKRLYQEAELVHADLSEYNIMYIDK--------VYFIDMGQAVTLRHPMAE 225 Query: 267 YYFQRDVDCIRRFFKK 282 Y +RDV I RFF K Sbjct: 226 SYLERDVRNIIRFFSK 241 >6G5I-z nrPDB Length = 568 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 77/403 (19%), Positives = 153/403 (37%), Gaps = 63/403 (15%) Query: 53 ISDLAKLSLISKMRNVKYDGYRL--------TYNGID---YLALKTMLNRDTVYSVGNTI 101 ++D + K R + D YR+ +D + L ML R + + I Sbjct: 127 VTDSVINKVTEKSRQKEADMYRIKDKADRATVEQVLDPRTRMILFKMLTRGIITEINGCI 186 Query: 102 GVGKESDIYKVSDKNGNPRVMKIHRLGRTSFHSVRNNRDYLK---KSNQG---ANWMHLS 155 GKE+++Y S NG R +KI++ TS ++ Y+ + G N + Sbjct: 187 STGKEANVYHASTANGESRAIKIYK---TSILVFKDRDKYVSGEFRFRHGYCKGNPRKMV 243 Query: 156 RLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELI--EGYPMRRLR----KHKNIPKL 209 + A KE + + L + PEP H++VM I + P L+ +L Sbjct: 244 KTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQLSESKAREL 303 Query: 210 YSDLMCFIVDLA-NSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQHQDADYY 268 Y ++ ++ + ++ L+H D +EFN++ + G +ID Q + H A + Sbjct: 304 YLQVIQYMRRMYQDARLVHADLSEFNMLY-------HGGGVYIIDVSQSVEHDHPHALEF 356 Query: 269 FQRDVDCIRRFFKKK----------LKYEPKPDSSMLDTEGF-GDGYKYAYPDFKRDVKR 317 ++D + FF + ++ P + + + + + A K + Sbjct: 357 LRKDCANVNDFFMRHSVAVMTVRELFEFVTDPSITHENMDAYLSKAMEIASQRTKEERSS 416 Query: 318 TDNLDELVQASGF-------SKKHPGDRGLETAVESMRNAVYNSDDDM--SNDEAEEENG 368 D++DE V + K + D + ++ A+ D++ +++ Sbjct: 417 QDHVDEEVFKRAYIPRTLNEVKNYERDMDIIMKLKEEDMAMNAQQDNILYQTVTGLKKDL 476 Query: 369 EG---------DYSEEDEYYDSELDNESSEDDSEDAQEEENER 402 G + EE DSE S D++ ++ ++ R Sbjct: 477 SGVQKVPALLENQVEERTCSDSEDIGSSECSDTDSEEQGDHAR 519 >5AP3-A nrPDB Length = 313 Score = 49.8 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 30/180 (16%), Positives = 65/180 (36%), Gaps = 30/180 (16%) Query: 79 GIDYLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPRVMKIHRLGRTSFHSVRNN 138 G + L ++M + +YS+ IG G S +++V ++ +K L ++ + Sbjct: 14 GTENLYFQSMSVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSY 73 Query: 139 RDYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRH----IVVMEL--I 192 R E +++ L K+ +D +VME I Sbjct: 74 R---------------------NEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNI 112 Query: 193 EGYPMRRLRKHKNI---PKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGF 249 + + +K + + +++ + + G++H D N +I D + D G Sbjct: 113 DLNGWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGI 172 >6GVJ-A nrPDB Length = 429 Score = 48.6 bits (114), Expect = 6e-06, Method: Composition-based stats. Identities = 27/171 (15%), Positives = 60/171 (35%), Gaps = 30/171 (17%) Query: 88 MLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQ 147 + + +YS+ IG G S +++V ++ +K L ++ + R Sbjct: 139 ISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYR-------- 190 Query: 148 GANWMHLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRH----IVVMEL--IEGYPMRRLR 201 E +++ L K+ +D +VME I+ + + Sbjct: 191 -------------NEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKK 237 Query: 202 KHKNI---PKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGF 249 K + + +++ + + G++H D N +I D + D G Sbjct: 238 KSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGI 288 >3HMP-A nrPDB Length = 342 Score = 46.3 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 27/171 (15%), Positives = 60/171 (35%), Gaps = 30/171 (17%) Query: 88 MLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQ 147 + + +YS+ IG G S +++V ++ +K L ++ + R Sbjct: 51 ISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYR-------- 102 Query: 148 GANWMHLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRH----IVVMEL--IEGYPMRRLR 201 E +++ L K+ +D +VME I+ + + Sbjct: 103 -------------NEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKK 149 Query: 202 KHKNI---PKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGF 249 K + + +++ + + G++H D N +I D + D G Sbjct: 150 KSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGI 200 >2ZMD-A nrPDB Length = 390 Score = 45.9 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 27/171 (15%), Positives = 60/171 (35%), Gaps = 30/171 (17%) Query: 88 MLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQ 147 + + +YS+ IG G S +++V ++ +K L ++ + R Sbjct: 51 ISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYR-------- 102 Query: 148 GANWMHLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRH----IVVMEL--IEGYPMRRLR 201 E +++ L K+ +D +VME I+ + + Sbjct: 103 -------------NEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKK 149 Query: 202 KHKNI---PKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGF 249 K + + +++ + + G++H D N +I D + D G Sbjct: 150 KSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGI 200 >3ENH-A nrPDB Length = 540 Score = 44.4 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 24/153 (15%), Positives = 53/153 (34%), Gaps = 24/153 (15%) Query: 116 NGNPRVMKIHRLGRTSFHSVRNNRDYLK---------KSNQGANWMH--LSRLAANKEYQ 164 G R + H +G+ + ++ YL K + + + +E + Sbjct: 333 KGKKRKIPEHLIGKGAEADIK-RDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREAR 391 Query: 165 FMSMLYSKGFKVPEPFD--NSRHIVVMELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLAN 222 +++++ G P FD ++M I G + + ++ + + + L Sbjct: 392 YLALVKDFGIPAPYIFDVDLDNKRIMMSYINGKLAKDV--IEDNLDIAYKIGEIVGKLHK 449 Query: 223 SGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFP 255 + +IH D N + D +IDF Sbjct: 450 NDVIHNDLTTSNFIF--------DKDLYIIDFG 474 >4IDT-A nrPDB Length = 356 Score = 43.6 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 27/149 (18%), Positives = 49/149 (32%), Gaps = 24/149 (16%) Query: 126 RLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRH 185 RLGR SF V D + L ++ ++ G P Sbjct: 81 RLGRGSFGEVHRMEDKQTGFQCAVKKVRLEV------FRAEELMACAGLTSPRIVPLYGA 134 Query: 186 I-------VVMELIEGYPMRRLRKH----KNIPKLY--SDLMCFIVDLANSGLIHCDFNE 232 + + MEL+EG + +L K LY + + L + ++H D Sbjct: 135 VREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKA 194 Query: 233 FNIMIKDKLEDENDCGFVVIDFPQCISIQ 261 N+++ + + DF + +Q Sbjct: 195 DNVLLS-----SDGSHAALCDFGHAVCLQ 218 >2JAM-A nrPDB Length = 304 Score = 41.3 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 17/110 (15%), Positives = 41/110 (37%), Gaps = 11/110 (10%) Query: 154 LSRLAANKEYQFMSMLYSKGFKVPEPF--DNSRHIVVMELIEGYPM------RRLRKHKN 205 + E + + + E + + +VM+L+ G + R + K+ Sbjct: 48 FRDSSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKD 107 Query: 206 IPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFP 255 + ++ + L +G++H D N++ L E + ++ DF Sbjct: 108 ASLVIQQVLSAVKYLHENGIVHRDLKPENLLY---LTPEENSKIMITDFG 154 >5U6Y-A nrPDB Length = 461 Score = 41.3 bits (95), Expect = 9e-04, Method: Composition-based stats. Identities = 25/159 (15%), Positives = 56/159 (35%), Gaps = 17/159 (10%) Query: 124 IHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAA------NKEYQFMSMLYSKGF-KV 176 LG+ +F VR L A ++ +L+A +E + +L ++ Sbjct: 5 FEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRL 64 Query: 177 PEPFDNSRHIVVM-------ELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCD 229 + H ++ EL E R + ++ ++ G++H D Sbjct: 65 HDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRD 124 Query: 230 FNEFNIMIKDKLEDENDCGFVVIDFPQCISIQHQDADYY 268 N+++ KL+ + DF I ++ + ++ Sbjct: 125 LKPENLLLASKLK---GAAVKLADFGLAIEVEGEQQAWF 160 >2VZ6-A nrPDB Length = 313 Score = 41.3 bits (95), Expect = 9e-04, Method: Composition-based stats. Identities = 25/159 (15%), Positives = 56/159 (35%), Gaps = 17/159 (10%) Query: 124 IHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAA------NKEYQFMSMLYSKGF-KV 176 LG+ +F VR L A ++ +L+A +E + +L ++ Sbjct: 27 FEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRL 86 Query: 177 PEPFDNSRHIVVM-------ELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCD 229 + H ++ EL E R + ++ ++ G++H D Sbjct: 87 HDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRD 146 Query: 230 FNEFNIMIKDKLEDENDCGFVVIDFPQCISIQHQDADYY 268 N+++ KL+ + DF I ++ + ++ Sbjct: 147 LKPENLLLASKLK---GAAVKLADFGLAIEVEGEQQAWF 182 >4C0T-A nrPDB Length = 974 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 33/190 (17%), Positives = 73/190 (38%), Gaps = 26/190 (13%) Query: 85 LKTMLNRDTVYSVGNTIGVGKESDIYKVSDK-NGNPRVMKIHRLGRTSFHSVRNNR-DYL 142 +KT+ T + G +G G S + +DK G +K+ ++ + Y+ Sbjct: 258 MKTIRRNVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHI----IKEKKVKYV 313 Query: 143 KKSNQGANWM--HLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRL 200 N + L ++ +Q LY D + + ++ LI+ Y Sbjct: 314 NIEKHALNRLSNRLGVISLYFTFQDKDSLYF-------VLDYASNGELLTLIKRY---NT 363 Query: 201 RKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFP--QCI 258 + + ++ I + ++G+IH D NI++ DK+ + DF + + Sbjct: 364 LNEECTRHFGAQILDAIKYMHDNGVIHRDLKPENILLDDKMR------IQITDFGTARLL 417 Query: 259 SIQHQDADYY 268 ++ +++ Y Sbjct: 418 EKKNDESEEY 427 >3MA6-A nrPDB Length = 298 Score = 40.6 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 31/182 (17%), Positives = 60/182 (32%), Gaps = 16/182 (8%) Query: 75 LTYNGIDYLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDK-NGNPRVMKIHRLGRTSFH 133 L + G + Y +G G ++ DK G +K+ S Sbjct: 14 LYFQGPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKV-----ISKR 68 Query: 134 SVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIE 193 V+ D + L K Y+F + V E + EL + Sbjct: 69 QVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFED-KGYFYLVGEVYTGG------ELFD 121 Query: 194 GYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVID 253 R+ + ++ ++ I + + ++H D N++++ K +D N +ID Sbjct: 122 EIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDAN---IRIID 178 Query: 254 FP 255 F Sbjct: 179 FG 180 >2V7O-A nrPDB Length = 336 Score = 39.8 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 23/159 (14%), Positives = 55/159 (34%), Gaps = 17/159 (10%) Query: 124 IHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAA------NKEYQFMSMLYSKGF-KV 176 LG+ +F VR A ++ +L+A +E + +L ++ Sbjct: 36 FEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRL 95 Query: 177 PEPFDNSR-HIVVMELIEGYPM------RRLRKHKNIPKLYSDLMCFIVDLANSGLIHCD 229 + H +V +L+ G + R + ++ + + ++H D Sbjct: 96 HDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRD 155 Query: 230 FNEFNIMIKDKLEDENDCGFVVIDFPQCISIQHQDADYY 268 N+++ K + + DF I +Q + ++ Sbjct: 156 LKPENLLLASKCK---GAAVKLADFGLAIEVQGEQQAWF 191 >5FG8-A nrPDB Length = 285 Score = 39.8 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 23/157 (14%), Positives = 53/157 (33%), Gaps = 19/157 (12%) Query: 127 LGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMSMLYS--KGFKVPEPFDN-- 182 LG+ +F V+ A ++ +L A ++Q + + P Sbjct: 22 LGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTAR-DFQKLEREARICRKLHHPNIVRLHD 80 Query: 183 -----SRHIVVMELIEGYPM------RRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFN 231 + H +V +L+ G + R + ++ + +G++H D Sbjct: 81 SIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLK 140 Query: 232 EFNIMIKDKLEDENDCGFVVIDFPQCISIQHQDADYY 268 N+++ K + + DF I +Q ++ Sbjct: 141 PENLLLASKAK---GAAVKLADFGLAIEVQGDHQAWF 174 >3DFA-A nrPDB Length = 286 Score = 39.4 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 15/66 (22%), Positives = 28/66 (42%), Gaps = 3/66 (4%) Query: 190 ELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGF 249 EL + R+ + ++ + I + ++H D NI+++ K E DC Sbjct: 107 ELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHNIVHRDLKPENILLESK---EKDCDI 163 Query: 250 VVIDFP 255 +IDF Sbjct: 164 KIIDFG 169 >3ORP-A nrPDB Length = 311 Score = 39.4 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 32/151 (21%), Positives = 58/151 (38%), Gaps = 21/151 (13%) Query: 95 YSVGNTIGVGKESDIYKVSD-KNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMH 153 Y +G +G G S+++ D ++ +K+ R R+ YL+ + N Sbjct: 14 YELGEILGFGGMSEVHLARDLRDHRDVAVKVLRAD-----LARDPSFYLRFRREAQNAAA 68 Query: 154 LSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKHKNIP------ 207 L+ A Y G P P+ +VME ++G +R + + Sbjct: 69 LNHPAIVAVYDTGEAETPAG---PLPY------IVMEYVDGVTLRDIVHTEGPMTPKRAI 119 Query: 208 KLYSDLMCFIVDLANSGLIHCDFNEFNIMIK 238 ++ +D + +G+IH D NIMI Sbjct: 120 EVIADACQALNFSHQNGIIHRDVKPANIMIS 150 >3E7O-A nrPDB Length = 360 Score = 39.0 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 20/73 (27%), Positives = 38/73 (52%), Gaps = 11/73 (15%) Query: 187 VVMELIEGYPMRRLRK----HKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLE 242 +VMEL++ + ++ H+ + L ++C I L ++G+IH D NI++K Sbjct: 104 LVMELMDA-NLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK---- 158 Query: 243 DENDCGFVVIDFP 255 +DC ++DF Sbjct: 159 --SDCTLKILDFG 169 >5JN2-A nrPDB Length = 525 Score = 38.6 bits (88), Expect = 0.005, Method: Composition-based stats. Identities = 28/157 (17%), Positives = 55/157 (35%), Gaps = 16/157 (10%) Query: 100 TIGVGKESDIYKVSDK-NGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLA 158 +G G ++ DK G +K+ S V+ D + L Sbjct: 74 VLGKGSFGEVILCKDKITGQECAVKV-----ISKRQVKQKTDKESLLREVQLLKQLDHPN 128 Query: 159 ANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKHKNIPKLYSDLMCFIV 218 K Y+F + V E + EL + R+ + ++ ++ I Sbjct: 129 IMKLYEFFED-KGYFYLVGEVYTGG------ELFDEIISRKRFSEVDAARIIRQVLSGIT 181 Query: 219 DLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFP 255 + + ++H D N++++ K +D N +IDF Sbjct: 182 YMHKNKIVHRDLKPENLLLESKSKDAN---IRIIDFG 215 >3LM0-A nrPDB Length = 327 Score = 38.6 bits (88), Expect = 0.006, Method: Composition-based stats. Identities = 28/173 (16%), Positives = 55/173 (31%), Gaps = 21/173 (12%) Query: 108 DIYKVSDKNGNPR-VMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLA--ANKEYQ 164 ++Y S +N N ++ LGR F VR A ++ R E Sbjct: 17 NLYFQSMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEIL 76 Query: 165 FMSMLYSKGFKVPEPFDN-------SRHIVVMELIEG--------YPMRRLRKHKNIPKL 209 + P + S I+++E G + + ++ +L Sbjct: 77 HEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRL 136 Query: 210 YSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQH 262 ++ + L + ++H D NI++ ++DF I H Sbjct: 137 IKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPL---GDIKIVDFGMSRKIGH 186 >4G3E-A nrPDB Length = 352 Score = 38.2 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 26/149 (17%), Positives = 49/149 (32%), Gaps = 24/149 (16%) Query: 126 RLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRH 185 R+GR SF V +D + L ++ ++ G P Sbjct: 81 RVGRGSFGEVHRMKDKQTGFQCAVKKVRLEV------FRVEELVACAGLSSPRIVPLYGA 134 Query: 186 I-------VVMELIEGYPMRRLRKH----KNIPKLY--SDLMCFIVDLANSGLIHCDFNE 232 + + MEL+EG + +L K LY + + L ++H D Sbjct: 135 VREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVKA 194 Query: 233 FNIMIKDKLEDENDCGFVVIDFPQCISIQ 261 N+++ + + DF + +Q Sbjct: 195 DNVLLS-----SDGSRAALCDFGHALCLQ 218 >3BHH-A nrPDB Length = 295 Score = 38.2 bits (87), Expect = 0.007, Method: Composition-based stats. Identities = 23/156 (14%), Positives = 55/156 (35%), Gaps = 17/156 (10%) Query: 127 LGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAA------NKEYQFMSMLYSKGF-KVPEP 179 +G+ +F VR A ++ +L+A +E + +L ++ + Sbjct: 12 IGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDS 71 Query: 180 FDNSR-HIVVMELIEGYPM------RRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNE 232 H +V +L+ G + R + ++ ++ G++H D Sbjct: 72 ISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKP 131 Query: 233 FNIMIKDKLEDENDCGFVVIDFPQCISIQHQDADYY 268 N+++ K + + DF I +Q ++ Sbjct: 132 ENLLLASKCK---GAAVKLADFGLAIEVQGDQQAWF 164 >3SOA-A nrPDB Length = 444 Score = 38.2 bits (87), Expect = 0.007, Method: Composition-based stats. Identities = 24/159 (15%), Positives = 56/159 (35%), Gaps = 17/159 (10%) Query: 124 IHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAA------NKEYQFMSMLYSKGF-KV 176 LG+ +F VR L A ++ +L+A +E + +L ++ Sbjct: 16 FEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKHPNIVRL 75 Query: 177 PEPFDNSRHIVVM-------ELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCD 229 + H ++ EL E R + ++ ++ G++H + Sbjct: 76 HDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRN 135 Query: 230 FNEFNIMIKDKLEDENDCGFVVIDFPQCISIQHQDADYY 268 N+++ KL+ + DF I ++ + ++ Sbjct: 136 LKPENLLLASKLK---GAAVKLADFGLAIEVEGEQQAWF 171 >3NCG-A nrPDB Length = 486 Score = 38.2 bits (87), Expect = 0.007, Method: Composition-based stats. Identities = 15/66 (22%), Positives = 28/66 (42%), Gaps = 3/66 (4%) Query: 190 ELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGF 249 EL + R+ + ++ + I + ++H D NI+++ K E DC Sbjct: 107 ELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHNIVHRDLKPENILLESK---EKDCDI 163 Query: 250 VVIDFP 255 +IDF Sbjct: 164 KIIDFG 169 >2BDW-A nrPDB Length = 362 Score = 38.2 bits (87), Expect = 0.007, Method: Composition-based stats. Identities = 32/183 (17%), Positives = 66/183 (36%), Gaps = 21/183 (11%) Query: 98 GNTIGVGKESDIYKVSDKNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRL 157 G +G G E + S K + +K LG+ +F VR A ++ +L Sbjct: 10 GQQMGRGSEF-MMNASTKFSDNYDVK-EELGKGAFSVVRRCVHKTTGLEFAAKIINTKKL 67 Query: 158 AANKEYQFMSMLYS--KGFKVPEPFDN-------SRHIVVMELIEGYPM------RRLRK 202 +A ++Q + + + P S H +V +L+ G + R Sbjct: 68 SAR-DFQKLEREARICRKLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYS 126 Query: 203 HKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQH 262 + ++ I ++G++H + N+++ K + + DF I + Sbjct: 127 EADASHCIQQILESIAYCHSNGIVHRNLKPENLLLASKAK---GAAVKLADFGLAIEVND 183 Query: 263 QDA 265 +A Sbjct: 184 SEA 186 >5ZTN-A nrPDB Length = 429 Score = 38.2 bits (87), Expect = 0.007, Method: Composition-based stats. Identities = 40/185 (21%), Positives = 67/185 (36%), Gaps = 31/185 (16%) Query: 95 YSVGNTIGVGKESDIYKVSDKNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWM-H 153 Y V IG G + K D K+H+ + VRN + + +++ + + H Sbjct: 99 YEVLKVIGKGSFGQVVKAYDH-------KVHQ--HVALKMVRNEKRFHRQAAEEIRILEH 149 Query: 154 LSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKHKN-------- 205 L + + + ML E F HI + + + L K Sbjct: 150 LRKQDKDNTMNVIHML--------ENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPL 201 Query: 206 IPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQHQDA 265 + K ++ + L + +IHCD NI++K + G VIDF +HQ Sbjct: 202 VRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGR----SGIKVIDFGSSC-YEHQRV 256 Query: 266 DYYFQ 270 Y Q Sbjct: 257 YTYIQ 261 >1JNK-A nrPDB Length = 423 Score = 37.9 bits (86), Expect = 0.010, Method: Composition-based stats. Identities = 20/73 (27%), Positives = 38/73 (52%), Gaps = 11/73 (15%) Query: 187 VVMELIEGYPMRRL----RKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLE 242 +VMEL++ + ++ H+ + L ++C I L ++G+IH D NI++K Sbjct: 144 LVMELMDA-NLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK---- 198 Query: 243 DENDCGFVVIDFP 255 +DC ++DF Sbjct: 199 --SDCTLKILDFG 209 >4JLC-A nrPDB Length = 657 Score = 37.5 bits (85), Expect = 0.010, Method: Composition-based stats. Identities = 26/174 (14%), Positives = 57/174 (32%), Gaps = 27/174 (15%) Query: 160 NKEYQFMSMLYSKG----FKVPEPFDNSRHIVVMELIEGYPMRRLRKHKN-----IPK-- 208 +E++ + L K F + E +++ME + + + + Sbjct: 54 MREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEF 113 Query: 209 --LYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFV-VIDFPQCISIQHQ-- 263 + D++ + L +G++H D NIM ++ E+ + DF ++ Sbjct: 114 LIVLRDVVGGMNHLRENGIVHRDIKPGNIM---RVIGEDGQSVYKLTDFGAARELEDDEQ 170 Query: 264 -----DADYYFQRDV---DCIRRFFKKKLKYEPKPDSSMLDTEGFGDGYKYAYP 309 + Y D+ +R+ +KK S + G P Sbjct: 171 FVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRP 224 >2XS0-A nrPDB Length = 386 Score = 37.5 bits (85), Expect = 0.010, Method: Composition-based stats. Identities = 20/73 (27%), Positives = 38/73 (52%), Gaps = 11/73 (15%) Query: 187 VVMELIEGYPMRRL----RKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLE 242 +VMEL++ + ++ H+ + L ++C I L ++G+IH D NI++K Sbjct: 108 IVMELMDA-NLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK---- 162 Query: 243 DENDCGFVVIDFP 255 +DC ++DF Sbjct: 163 --SDCTLKILDFG 173 >3FI2-A nrPDB Length = 353 Score = 37.5 bits (85), Expect = 0.011, Method: Composition-based stats. Identities = 20/73 (27%), Positives = 38/73 (52%), Gaps = 11/73 (15%) Query: 187 VVMELIEGYPMRRL----RKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLE 242 +VMEL++ + ++ H+ + L ++C I L ++G+IH D NI++K Sbjct: 106 LVMELMDA-NLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK---- 160 Query: 243 DENDCGFVVIDFP 255 +DC ++DF Sbjct: 161 --SDCTLKILDFG 171 >2A27-A nrPDB Length = 321 Score = 37.1 bits (84), Expect = 0.013, Method: Composition-based stats. Identities = 25/160 (15%), Positives = 54/160 (33%), Gaps = 10/160 (6%) Query: 110 YKVSDKNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFM-SM 168 + + I + R + ++KK A+ +SR +E + + Sbjct: 13 FYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQV 72 Query: 169 LYSKGFKVPEPFDNSRHIVVM-------ELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLA 221 L+ + + ++N +V++ EL + + + ++ + L Sbjct: 73 LHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLH 132 Query: 222 NSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQ 261 + H D NIM+ DK +IDF I+ Sbjct: 133 TKKIAHFDLKPENIMLLDKNIPI--PHIKLIDFGLAHEIE 170 >3DXN-A nrPDB Length = 287 Score = 37.1 bits (84), Expect = 0.014, Method: Composition-based stats. Identities = 29/163 (17%), Positives = 57/163 (34%), Gaps = 26/163 (15%) Query: 99 NTIGVGKESDIYKVSDK-NGNPRVMKIHRLGRTSFHSVRNNRDYLK-----KSNQGANWM 152 +G G ++ DK G R +KI + ++S + N+ L K N M Sbjct: 27 KKLGSGAYGEVLLCKDKLTGAERAIKI--IKKSSVTTTSNSGALLDEVAVLKQLDHPNIM 84 Query: 153 HLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKHKNIPKLYSD 212 L +K ++ M +G EL + +R+ + + Sbjct: 85 KLYEFFEDKRNYYLVMEVYRG---------------GELFDEIILRQKFSEVDAAVIMKQ 129 Query: 213 LMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFP 255 ++ L ++H D N++++ K D ++DF Sbjct: 130 VLSGTTYLHKHNIVHRDLKPENLLLESKSRDAL---IKIVDFG 169 >2W4O-A nrPDB Length = 349 Score = 37.1 bits (84), Expect = 0.014, Method: Composition-based stats. Identities = 27/166 (16%), Positives = 59/166 (35%), Gaps = 22/166 (13%) Query: 107 SDIYKVSDKNGNPRVMKIHRL---GRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEY 163 SD ++V + G ++R G ++++ + + K L RL+ + Sbjct: 52 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLS----H 107 Query: 164 QFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRR------LRKHKNIPKLYSDLMCFI 217 + L F+ P +V+EL+ G + ++ ++ + Sbjct: 108 PNIIKLKEI-FETPTEIS-----LVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAV 161 Query: 218 VDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQHQ 263 L +G++H D N++ D + DF ++HQ Sbjct: 162 AYLHENGIVHRDLKPENLLYATPAPDAP---LKIADFGLSKIVEHQ 204 >1ZWS-A nrPDB Length = 288 Score = 37.1 bits (84), Expect = 0.015, Method: Composition-based stats. Identities = 25/160 (15%), Positives = 54/160 (33%), Gaps = 10/160 (6%) Query: 110 YKVSDKNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFM-SM 168 + + I + R + ++KK A+ +SR +E + + Sbjct: 13 FYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQV 72 Query: 169 LYSKGFKVPEPFDNSRHIVVM-------ELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLA 221 L+ + + ++N +V++ EL + + + ++ + L Sbjct: 73 LHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLH 132 Query: 222 NSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQ 261 + H D NIM+ DK +IDF I+ Sbjct: 133 TKKIAHFDLKPENIMLLDKNIPI--PHIKLIDFGLAHEIE 170 >3GUB-A nrPDB Length = 295 Score = 36.7 bits (83), Expect = 0.018, Method: Composition-based stats. Identities = 23/171 (13%), Positives = 62/171 (36%), Gaps = 12/171 (7%) Query: 101 IGVGKESDI--YKVSDKNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLA 158 + V ++ ++ Y + + + + R ++ ++KK ++ +SR Sbjct: 1 MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSRED 60 Query: 159 ANKEYQFMSMLYSKG-FKVPEPFDNSRHIVVM-------ELIEGYPMRRLRKHKNIPKLY 210 +E + + + E ++N ++++ EL + + + + Sbjct: 61 IEREVSILKEIQHPNVITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFL 120 Query: 211 SDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQ 261 ++ + L + + H D NIM+ D+ + +IDF I Sbjct: 121 KQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPK--PRIKIIDFGLAHKID 169 >5D7A-A nrPDB Length = 308 Score = 36.7 bits (83), Expect = 0.019, Method: Composition-based stats. Identities = 35/239 (14%), Positives = 74/239 (30%), Gaps = 39/239 (16%) Query: 79 GIDYLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKN-GNPRVMKIHRLGRTSFHSVRN 137 G D + L + + ++ + +G G +YK G +K+ + ++ Sbjct: 3 GADEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQ 62 Query: 138 NRDYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPM 197 + LKK + ++ ++ Y K P + + +VME + Sbjct: 63 EINMLKKYSH---------------HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSV 107 Query: 198 RRLRKHKNIPKLYSDLMCFIVD--------LANSGLIHCDFNEFNIMIKDKLEDENDCGF 249 L K+ L + + +I L +IH D N+++ + E Sbjct: 108 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAE------V 161 Query: 250 VVIDFPQCISIQHQDADYYFQRDVDCIRRFFKKKLKYEPKPDSSMLDTEGFGDGYKYAY 308 ++DF R V F P+ + + + D + Sbjct: 162 KLVDFGVSAQ---------LDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLW 211 >1PHK-A nrPDB Length = 298 Score = 36.7 bits (83), Expect = 0.019, Method: Composition-based stats. Identities = 36/199 (18%), Positives = 61/199 (30%), Gaps = 28/199 (14%) Query: 66 RNVKYDGYRLTYNGIDYLALKTMLNRDTVYSVGNTIG--VGKESDIYKVSDKNGNPR-VM 122 R+ G T+ + K +L R V I KE + + G Sbjct: 2 RDAALPGSHSTHGFYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAE 61 Query: 123 KIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEPFDN 182 ++ L + V D L+K + N + L + F+ FD Sbjct: 62 EVQELREATLKEV----DILRKVSGHPNIIQLKDTYETNTFFFL------------VFDL 105 Query: 183 SRHIVVMELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLE 242 + EL + + K K+ L+ I L ++H D NI++ D Sbjct: 106 MKKG---ELFDYLTEKVTLSEKETRKIMRALLEVICALHKLNIVHRDLKPENILLDD--- 159 Query: 243 DENDCGFVVIDFPQCISIQ 261 D + DF + Sbjct: 160 ---DMNIKLTDFGFSCQLD 175 >5AWM-A nrPDB Length = 394 Score = 36.7 bits (83), Expect = 0.020, Method: Composition-based stats. Identities = 26/109 (23%), Positives = 50/109 (45%), Gaps = 19/109 (17%) Query: 159 ANKEYQFMSMLYSKGF-KVPEPFDNSRHI-------VVMELIEGYPMRRL----RKHKNI 206 A +E++ M ++ K + F R++ +VMEL++ + ++ H + Sbjct: 90 AYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQMDLDHDRM 148 Query: 207 PKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFP 255 L ++C I L ++G+IH D NI++K DC ++DF Sbjct: 149 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK------ADCTLKILDFG 191 >4D28-A nrPDB Length = 446 Score = 36.3 bits (82), Expect = 0.024, Method: Composition-based stats. Identities = 25/153 (16%), Positives = 55/153 (35%), Gaps = 14/153 (9%) Query: 86 KTMLNRDTVYSVGNTIGVGKESDIYKVSDKN-GNPRVMKIHRLGRTSFHSVRNNRDYLKK 144 K M Y VG TIG G + + + + G+ +KI + +++ + + Sbjct: 3 KKMRRVGK-YEVGRTIGEGTFAKVKFARNTDTGDNVAIKI--MAKSTIL----KNRMVDQ 55 Query: 145 SNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKHK 204 + + M + R + + LY + + + EL + + K Sbjct: 56 IKREISIMKIVR------HPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKED 109 Query: 205 NIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMI 237 K + L+ + + G+ H D N+++ Sbjct: 110 ESRKYFQQLVDAVAHCHSKGVYHRDLKPENLLL 142 >4YZB-A nrPDB Length = 491 Score = 36.3 bits (82), Expect = 0.026, Method: Composition-based stats. Identities = 28/157 (17%), Positives = 56/157 (35%), Gaps = 16/157 (10%) Query: 100 TIGVGKESDIYKVSDK-NGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLA 158 +G G ++ DK G +K+ S V+ D + L Sbjct: 37 VLGKGSFGEVILCKDKVTGQEYAVKV-----ISKRQVKQKTDKELLLKEVELLKKLDHPN 91 Query: 159 ANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKHKNIPKLYSDLMCFIV 218 K Y+F + V E + EL + R+ + ++ ++ I Sbjct: 92 IMKLYEFFED-KGYFYLVTEVYTGG------ELFDEIISRKRFSEVDAARIIRQVLSGIT 144 Query: 219 DLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFP 255 + + ++H D N+++++K +D N +IDF Sbjct: 145 YMHKNKIVHRDLKPENLLLENKRKDAN---IRIIDFG 178 >3HZT-A nrPDB Length = 467 Score = 35.9 bits (81), Expect = 0.029, Method: Composition-based stats. Identities = 29/163 (17%), Positives = 57/163 (34%), Gaps = 26/163 (15%) Query: 99 NTIGVGKESDIYKVSDK-NGNPRVMKIHRLGRTSFHSVRNNRDYLK-----KSNQGANWM 152 +G G ++ DK G R +KI + ++S + N+ L K N M Sbjct: 10 KKLGSGAYGEVLLCKDKLTGAERAIKI--IKKSSVTTTSNSGALLDEVAVLKQLDHPNIM 67 Query: 153 HLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKHKNIPKLYSD 212 L +K ++ M +G EL + +R+ + + Sbjct: 68 KLYEFFEDKRNYYLVMEVYRG---------------GELFDEIILRQKFSEVDAAVIMKQ 112 Query: 213 LMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFP 255 ++ L ++H D N++++ K D ++DF Sbjct: 113 VLSGTTYLHKHNIVHRDLKPENLLLESKSRDAL---IKIVDFG 152 >3KN6-A nrPDB Length = 325 Score = 35.9 bits (81), Expect = 0.031, Method: Composition-based stats. Identities = 16/75 (21%), Positives = 34/75 (45%), Gaps = 9/75 (12%) Query: 187 VVMELIEGYPMR-RLRK-----HKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDK 240 +VMEL+ G + R++K + L+ + + + G++H D N++ D+ Sbjct: 83 LVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDE 142 Query: 241 LEDENDCGFVVIDFP 255 ++ +IDF Sbjct: 143 NDNLE---IKIIDFG 154 >1U5R-A nrPDB Length = 348 Score = 35.9 bits (81), Expect = 0.033, Method: Composition-based stats. Identities = 33/163 (20%), Positives = 55/163 (33%), Gaps = 26/163 (15%) Query: 98 GNTIGVGKESDIYKVSDKNGNPRVMK-IHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSR 156 G G K+ D+ ++ K+ ++ + +G SF +V RD M S Sbjct: 32 GGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSG 91 Query: 157 LAAN-------KEYQFMSMLYSKGFKVPEPFDNSR-----HI--VVMELIEGYPMRRLRK 202 +N KE +F+ L P H +VME G L Sbjct: 92 KQSNEKWQDIIKEVRFLQKLRH-----PNTIQYRGCYLREHTAWLVMEYCLGSASDLLEV 146 Query: 203 HKNI------PKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKD 239 HK + + + L + +IH D NI++ + Sbjct: 147 HKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSE 189 >5YK0-A nrPDB Length = 452 Score = 35.9 bits (81), Expect = 0.033, Method: Composition-based stats. Identities = 28/105 (26%), Positives = 43/105 (40%), Gaps = 11/105 (10%) Query: 156 RLAANKEYQFMSMLYSK-GFKVPEPFDNSRHIVVMELIEGYPMRRLRKH--KNIPKLYSD 212 RL A + F + F+VP ++ +V+ E IEG PM + +H L Sbjct: 213 RLEAANQRAFAKAYHDHPRFQVPHVVASAPKVVIQEWIEGVPMAEIIRHGTTEQRDLIGT 272 Query: 213 LMCFIVDLANS--GLIHCDFNEFNIMIKDKLEDENDCGFVVIDFP 255 L+ + A GL+H D + N M+ D +IDF Sbjct: 273 LLAELTFDAPRRLGLMHGDAHPGNFMLLP------DGRMGIIDFG 311 >2VN9-A nrPDB Length = 301 Score = 35.5 bits (80), Expect = 0.038, Method: Composition-based stats. Identities = 13/79 (16%), Positives = 27/79 (34%), Gaps = 3/79 (3%) Query: 190 ELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGF 249 EL E R + ++ + +G++H D N+++ K Sbjct: 89 ELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASK---SKGAAV 145 Query: 250 VVIDFPQCISIQHQDADYY 268 + DF I +Q ++ Sbjct: 146 KLADFGLAIEVQGDQQAWF 164 >6O8B-A nrPDB Length = 665 Score = 35.5 bits (80), Expect = 0.039, Method: Composition-based stats. Identities = 25/174 (14%), Positives = 57/174 (32%), Gaps = 27/174 (15%) Query: 160 NKEYQFMSMLYSKG----FKVPEPFDNSRHIVVMELIEGYPMRRLRKHKN-----IPK-- 208 +E++ + L K F + E +++ME + + + + Sbjct: 61 MREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEF 120 Query: 209 --LYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFV-VIDFPQCISIQHQ-- 263 + D++ + L +G++H + NIM ++ E+ + DF ++ Sbjct: 121 LIVLRDVVGGMNHLRENGIVHRNIKPGNIM---RVIGEDGQSVYKLTDFGAARELEDDEQ 177 Query: 264 -----DADYYFQRDV---DCIRRFFKKKLKYEPKPDSSMLDTEGFGDGYKYAYP 309 + Y D+ +R+ +KK S + G P Sbjct: 178 FVELYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRP 231 >3I6U-A nrPDB Length = 419 Score = 35.2 bits (79), Expect = 0.060, Method: Composition-based stats. Identities = 25/122 (20%), Positives = 47/122 (38%), Gaps = 10/122 (8%) Query: 143 KKSNQGANWMHLSRLAANKEYQFMSMLYSKGF-KVPEPFDNSRHIVVMELIEGYPMR--- 198 +K G+ L E + + L K+ FD + +V+EL+EG + Sbjct: 171 RKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKV 230 Query: 199 ---RLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFP 255 + K + ++ + L +G+IH D N+++ + E DC + DF Sbjct: 231 VGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQ---EEDCLIKITDFG 287 Query: 256 QC 257 Sbjct: 288 HS 289 >2PZI-A nrPDB Length = 681 Score = 35.2 bits (79), Expect = 0.064, Method: Composition-based stats. Identities = 32/162 (19%), Positives = 57/162 (35%), Gaps = 25/162 (15%) Query: 95 YSVGNTIGVGKESDIYKV--SDKNGNPRVMK--IHRLGRTSFHSVRNNRDYLKKSNQGAN 150 Y V I G IY + NG P V+K +H + R +L + Sbjct: 82 YEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVVHP-- 139 Query: 151 WMHLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKHKNIPK-- 208 + + + F+ G V +VME + G ++R + K Sbjct: 140 -------SIVQIFNFVEHTDRHGDPV--------GYIVMEYVGGQSLKRSKGQKLPVAEA 184 Query: 209 --LYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCG 248 +++ + L + GL++ D NIM+ ++ D G Sbjct: 185 IAYLLEILPALSYLHSIGLVYNDLKPENIMLTEEQLKLIDLG 226 >4JG6-A nrPDB Length = 355 Score = 34.8 bits (78), Expect = 0.065, Method: Composition-based stats. Identities = 12/75 (16%), Positives = 29/75 (38%), Gaps = 2/75 (2%) Query: 190 ELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGF 249 EL++ ++ + + + + L G++H D NI+ D+ N Sbjct: 115 ELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDE--SGNPESI 172 Query: 250 VVIDFPQCISIQHQD 264 + DF ++ ++ Sbjct: 173 RICDFGFAKQLRAEN 187 >2YAB-A nrPDB Length = 361 Score = 34.8 bits (78), Expect = 0.066, Method: Composition-based stats. Identities = 30/189 (15%), Positives = 63/189 (33%), Gaps = 28/189 (14%) Query: 82 YLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKN-GNPRVMKIHRLGRTSFHSVRNNRD 140 + + Y +G +G G+ + + K +K+ G K Sbjct: 1 GMETFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKF---------------- 44 Query: 141 YLKKSNQGANWMHLSRLAANKEYQFM-SMLYSKGFKVPEPFDNSRHIVVM-------ELI 192 +KK A+ + R +E + +L+ + + ++N +V++ EL Sbjct: 45 -IKKRQSRASRRGVCREEIEREVSILRQVLHPNIITLHDVYENRTDVVLILELVSGGELF 103 Query: 193 EGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVI 252 + + + ++ + L + H D NIM+ DK +I Sbjct: 104 DFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPI--PHIKLI 161 Query: 253 DFPQCISIQ 261 DF I+ Sbjct: 162 DFGLAHEIE 170 >2YCR-A nrPDB Length = 323 Score = 34.8 bits (78), Expect = 0.068, Method: Composition-based stats. Identities = 25/122 (20%), Positives = 47/122 (38%), Gaps = 10/122 (8%) Query: 143 KKSNQGANWMHLSRLAANKEYQFMSMLYSKGF-KVPEPFDNSRHIVVMELIEGYPMR--- 198 +K G+ L E + + L K+ FD + +V+EL+EG + Sbjct: 46 RKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKV 105 Query: 199 ---RLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFP 255 + K + ++ + L +G+IH D N+++ + E DC + DF Sbjct: 106 VGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQ---EEDCLIKITDFG 162 Query: 256 QC 257 Sbjct: 163 HS 164 >4Y12-A nrPDB Length = 375 Score = 34.8 bits (78), Expect = 0.082, Method: Composition-based stats. Identities = 32/162 (19%), Positives = 57/162 (35%), Gaps = 25/162 (15%) Query: 95 YSVGNTIGVGKESDIYKV--SDKNGNPRVMK--IHRLGRTSFHSVRNNRDYLKKSNQGAN 150 Y V I G IY + NG P V+K +H + R +L + Sbjct: 121 YEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVVHP-- 178 Query: 151 WMHLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKHKNIPK-- 208 + + + F+ G V +VME + G ++R + K Sbjct: 179 -------SIVQIFNFVEHTDRHGDPV--------GYIVMEYVGGQSLKRSKGQKLPVAEA 223 Query: 209 --LYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCG 248 +++ + L + GL++ D NIM+ ++ D G Sbjct: 224 IAYLLEILPALSYLHSIGLVYNDLKPENIMLTEEQLKLIDLG 265 >4FG9-A nrPDB Length = 320 Score = 34.4 bits (77), Expect = 0.086, Method: Composition-based stats. Identities = 14/106 (13%), Positives = 42/106 (39%), Gaps = 11/106 (10%) Query: 158 AANKEYQFMSMLYSKGF-KVPEPFDNSRHI-VVMELIEGYPMRR------LRKHKNIPKL 209 + E + + + + +++ H+ ++M+L+ G + ++ +L Sbjct: 62 SMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRL 121 Query: 210 YSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFP 255 ++ + L + G++H D N++ + D ++ DF Sbjct: 122 IFQVLDAVKYLHDLGIVHRDLKPENLLY---YSLDEDSKIMISDFG 164 >3KK8-A nrPDB Length = 284 Score = 34.4 bits (77), Expect = 0.090, Method: Composition-based stats. Identities = 13/76 (17%), Positives = 28/76 (36%), Gaps = 3/76 (3%) Query: 190 ELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGF 249 EL E R + ++ I ++G++H + N+++ K + Sbjct: 91 ELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIVHRNLKPENLLLASKAK---GAAV 147 Query: 250 VVIDFPQCISIQHQDA 265 + DF I + +A Sbjct: 148 KLADFGLAIEVNDSEA 163 >2JC6-A nrPDB Length = 334 Score = 34.4 bits (77), Expect = 0.11, Method: Composition-based stats. Identities = 17/106 (16%), Positives = 38/106 (35%), Gaps = 11/106 (10%) Query: 158 AANKEYQFMSMLYSKGFKVPEPFDNSRH--IVVMELIEGYPMRR------LRKHKNIPKL 209 + E + + + E S + +VM+L+ G + K+ L Sbjct: 66 SIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTL 125 Query: 210 YSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFP 255 ++ + L G++H D N++ + E+ ++ DF Sbjct: 126 IRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEE---SKIMISDFG 168 >3MN3-A nrPDB Length = 271 Score = 34.0 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 19/149 (12%), Positives = 47/149 (31%), Gaps = 14/149 (9%) Query: 95 YSVGNTIGVGKESDIYKVS-DKNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMH 153 Y + T+G G + G +KI V D + + +++ Sbjct: 6 YQIVKTLGEGSFGKVKLAYHTTTGQKVALKIIN------KKVLAKSDMQGRIEREISYLR 59 Query: 154 LSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKHKNIPKLYSDL 213 L R + + + V + + + EL + R + + + + Sbjct: 60 LLRHPHIIKLYDVIKSKDEIIMV---IEYAGN----ELFDYIVQRDKMSEQEARRFFQQI 112 Query: 214 MCFIVDLANSGLIHCDFNEFNIMIKDKLE 242 + + ++H D N+++ + L Sbjct: 113 ISAVEYCHRHKIVHRDLKPENLLLDEHLN 141 >5Y86-A nrPDB Length = 588 Score = 34.0 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 37/159 (23%), Positives = 56/159 (35%), Gaps = 32/159 (20%) Query: 121 VMKIHRLGRTSFHSVRNNRDYLKKSNQGA------NWMHLSRLAANKEYQFMSMLYSKG- 173 V+KI +G+ SF V R Y K Q N R AA E + + L + Sbjct: 211 VLKI--IGKGSFGQVA--RVYDHKLRQYVALKMVRNEKRFHRQAAE-EIRILEHLKKQDK 265 Query: 174 ------FKVPEPFDNSRHIVVMEL----IEGYPM-----RRLRKHKNIPKLYSDLMCFIV 218 + E F H V M I+ Y + + + + K ++ + Sbjct: 266 TGSMNVIHMLESFTFRNH-VCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLD 324 Query: 219 DLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQC 257 L + +IHCD NI++K VIDF Sbjct: 325 ALHKNKIIHCDLKPENILLKHHGRSSTK----VIDFGSS 359 >4AZW-A nrPDB Length = 471 Score = 34.0 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 24/138 (17%), Positives = 47/138 (34%), Gaps = 24/138 (17%) Query: 139 RDYLKKSNQGANWMHLSRLAANKEYQFMSMLYS---------KGFKVPEPFDNSRHI--- 186 DY+ K + L A + + L++ GF P + + Sbjct: 260 EDYVCKFFYYDMPHGI--LTAEESQRNKHELHNEIKFLTQPPAGFDAPAVLAHGENAQSG 317 Query: 187 -VVMELIEGYPMRRLRK---HKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLE 242 +VME + G + + + K+ L+ + L G H D +N+M+ + Sbjct: 318 WLVMEKLPGRLLSDMLAAGEEIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMVDARQH 377 Query: 243 DENDCGFVVIDFPQCISI 260 +IDF ++ Sbjct: 378 AR------LIDFGSIVTT 389 >2CMW-A nrPDB Length = 310 Score = 34.0 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 37/202 (18%), Positives = 70/202 (34%), Gaps = 18/202 (8%) Query: 162 EYQFMSMLYSKGFKVPEPFDN----SRHIVVMELI-----EGYPMR-RLRKHKNIPKLYS 211 EY+F L S G +P+ + + +V+EL+ + + + R K + + Sbjct: 45 EYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAI 104 Query: 212 DLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQHQDADYYF-- 269 L+ + + + LI+ D N +I + + +IDF + + Sbjct: 105 QLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHV-IHIIDFGLAKEYIDPETKKHIPY 163 Query: 270 --QRDVDCIRRFFKKKLKYEPKPDSSMLDTEGFGDGYKYAYP-DFKRDVKRTDNLDELVQ 326 + + R+ + S D E G + Y + D L E Q Sbjct: 164 REHKSLTGTARYMSINTHLGKE-QSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQ 222 Query: 327 ASGFSKK-HPGDRGLETAVESM 347 G +K+ P + E E M Sbjct: 223 KIGDTKRNTPIEALCENFPEEM 244 >4BVU-A nrPDB Length = 211 Score = 33.6 bits (75), Expect = 0.15, Method: Composition-based stats. Identities = 28/140 (20%), Positives = 49/140 (35%), Gaps = 10/140 (7%) Query: 118 NPRVMKIHRLGRTS--FHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGFK 175 P + K+ G T+ F V ++ KK + N + A +E + + Y Sbjct: 41 EPILGKLIGQGSTAEIFEDVNDSSALYKKYDLIGNQYNEILEMAWQESELFNAFYGDEAS 100 Query: 176 VPEPFDNSRHIVV-MELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFN 234 V + + M + G P+ + + S + I L +IH D N N Sbjct: 101 V--VIQYGGDVYLRMLRVPGTPLSDIDTADIPDNIESLYLQLICKLNELSIIHYDLNTGN 158 Query: 235 IMIKDKLEDENDCGFVVIDF 254 ++ + E IDF Sbjct: 159 MLYDKESESLFP-----IDF 173 >4AZV-A nrPDB Length = 569 Score = 33.6 bits (75), Expect = 0.17, Method: Composition-based stats. Identities = 20/107 (18%), Positives = 40/107 (37%), Gaps = 14/107 (13%) Query: 161 KEYQFMSMLYSKGFKVPEPFDNSRHI----VVMELIEGYPMRRLRK---HKNIPKLYSDL 213 E +F++ GF P + + +VME + G + + + K+ L Sbjct: 290 NEIKFLTQ-PPAGFDAPAVLAHGENAQSGWLVMEKLPGRLLSDMLAAGEEIDREKILGSL 348 Query: 214 MCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISI 260 + + L G H D +N+M+ + +IDF ++ Sbjct: 349 LRSLAALEKQGFWHDDVRPWNVMVDARQHAR------LIDFGSIVTT 389 >2J90-A nrPDB Length = 304 Score = 33.6 bits (75), Expect = 0.18, Method: Composition-based stats. Identities = 28/170 (16%), Positives = 55/170 (32%), Gaps = 28/170 (16%) Query: 95 YSVGNTIGVGKESDIYKVSDK-NGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMH 153 Y +G +G G+ + + K K G K +KK ++ Sbjct: 28 YEMGEELGSGQFAIVRKCRQKGTGKEYAAKF-----------------IKKRRLSSSRRG 70 Query: 154 LSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVM--------ELIEGYPMRRLRKHKN 205 +SR +E + + ++ VV+ EL + + Sbjct: 71 VSREEIEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDE 130 Query: 206 IPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFP 255 + ++ + L + + H D NIM+ DK + + +IDF Sbjct: 131 ATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDK--NVPNPRIKLIDFG 178 >4WNO-A nrPDB Length = 287 Score = 33.6 bits (75), Expect = 0.19, Method: Composition-based stats. Identities = 21/106 (19%), Positives = 35/106 (33%), Gaps = 11/106 (10%) Query: 161 KEYQFMSMLYSKGFKVPEPFDNSRHIV--VMELIEG------YPMRRLRKHKNIPKLYSD 212 KE + + L + F + V VME G R I Sbjct: 66 KEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQ 125 Query: 213 LMCFIVDLANSGLIHCDFNEFNIMIKD---KLEDENDCGFVVIDFP 255 + + L + G+IH D NI++ + + + N + DF Sbjct: 126 IAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFG 171 >5TUR-A nrPDB Length = 404 Score = 33.2 bits (74), Expect = 0.20, Method: Composition-based stats. Identities = 34/165 (20%), Positives = 59/165 (35%), Gaps = 18/165 (10%) Query: 95 YSVGNTIGVGKESDIYK-VSDKNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMH 153 Y VG +G G +Y + + P +K R S D+ + N M Sbjct: 129 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRIS--------DWGELPNGTRVPME 180 Query: 154 LSRLAANKE-YQFMSMLYSKGFKVPEPFDN--SRHIVVMELIEGYPMRRLRKHKNIPKLY 210 + L + + L F+ P+ F R V +L + R + + + Sbjct: 181 VVLLKKVSSGFSGVIRLLDW-FERPDSFVLILERPEPVQDLFDFITERGALQEELARSFF 239 Query: 211 SDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFP 255 ++ + N G++H D + NI+I D N +IDF Sbjct: 240 WQVLEAVRHCHNCGVLHRDIKDENILI-----DLNRGELKLIDFG 279 >4RC3-A nrPDB Length = 289 Score = 33.2 bits (74), Expect = 0.20, Method: Composition-based stats. Identities = 34/165 (20%), Positives = 59/165 (35%), Gaps = 18/165 (10%) Query: 95 YSVGNTIGVGKESDIYK-VSDKNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMH 153 Y VG +G G +Y + + P +K R S D+ + N M Sbjct: 14 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRIS--------DWGELPNGTRVPME 65 Query: 154 LSRLAANKE-YQFMSMLYSKGFKVPEPFDN--SRHIVVMELIEGYPMRRLRKHKNIPKLY 210 + L + + L F+ P+ F R V +L + R + + + Sbjct: 66 VVLLKKVSSGFSGVIRLLDW-FERPDSFVLILERPEPVQDLFDFITERGALQEELARSFF 124 Query: 211 SDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFP 255 ++ + N G++H D + NI+I D N +IDF Sbjct: 125 WQVLEAVRHCHNCGVLHRDIKDENILI-----DLNRGELKLIDFG 164 >3BGP-A nrPDB Length = 333 Score = 33.2 bits (74), Expect = 0.20, Method: Composition-based stats. Identities = 34/165 (20%), Positives = 59/165 (35%), Gaps = 18/165 (10%) Query: 95 YSVGNTIGVGKESDIYK-VSDKNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMH 153 Y VG +G G +Y + + P +K R S D+ + N M Sbjct: 58 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRIS--------DWGELPNGTRVPME 109 Query: 154 LSRLAANKE-YQFMSMLYSKGFKVPEPFDN--SRHIVVMELIEGYPMRRLRKHKNIPKLY 210 + L + + L F+ P+ F R V +L + R + + + Sbjct: 110 VVLLKKVSSGFSGVIRLLDW-FERPDSFVLILERPEPVQDLFDFITERGALQEELARSFF 168 Query: 211 SDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFP 255 ++ + N G++H D + NI+I D N +IDF Sbjct: 169 WQVLEAVRHCHNCGVLHRDIKDENILI-----DLNRGELKLIDFG 208 >2Y7J-A nrPDB Length = 365 Score = 33.2 bits (74), Expect = 0.22, Method: Composition-based stats. Identities = 26/146 (17%), Positives = 52/146 (35%), Gaps = 11/146 (7%) Query: 100 TIGVGKESDIYKV-SDKNGNPRVMKIHRL--GRTSFHSVRNNRDYLKKSNQGANWMHLSR 156 IG G S + + G+ +KI + R S + R+ ++ L + Sbjct: 101 VIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETH-----ILRQ 155 Query: 157 LAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKHKNIPKLYSDLMCF 216 +A + + Y + FD R EL + + K + L+ Sbjct: 156 VAGHPHIITLIDSYESSSFMFLVFDLMRKG---ELFDYLTEKVALSEKETRSIMRSLLEA 212 Query: 217 IVDLANSGLIHCDFNEFNIMIKDKLE 242 + L + ++H D NI++ D ++ Sbjct: 213 VSFLHANNIVHRDLKPENILLDDNMQ 238 >4CZT-A nrPDB Length = 464 Score = 33.2 bits (74), Expect = 0.24, Method: Composition-based stats. Identities = 27/178 (15%), Positives = 57/178 (32%), Gaps = 14/178 (7%) Query: 85 LKTMLNRDTVYSVGNTIGVGKESDIYKVSD-KNGNPRVMKIHRLGRTSFHSVRNNRDYLK 143 + + R Y +G T+G G + + + +NG+ +K V + LK Sbjct: 3 IHSGRTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIK-----------VIDKEKVLK 51 Query: 144 KSNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKH 203 +S + K + ++ + + + EL + K Sbjct: 52 NKMIAQIKREISTMKLIKH-PNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKE 110 Query: 204 KNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQ 261 K + L+ + + G+ H D N+++ D F + PQ + Sbjct: 111 DEARKYFQQLINAVDYCHSRGVYHRDLKPENLLL-DANGALKVSDFGLSALPQQVRED 167 >3LIJ-A nrPDB Length = 494 Score = 32.9 bits (73), Expect = 0.28, Method: Composition-based stats. Identities = 12/66 (18%), Positives = 26/66 (39%), Gaps = 3/66 (4%) Query: 190 ELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGF 249 EL + R + + ++ + L ++H D N++++ K E D Sbjct: 122 ELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHKHNIVHRDLKPENLLLESK---EKDALI 178 Query: 250 VVIDFP 255 ++DF Sbjct: 179 KIVDFG 184 >5CLR-A nrPDB Length = 451 Score = 32.9 bits (73), Expect = 0.31, Method: Composition-based stats. Identities = 17/89 (19%), Positives = 31/89 (34%), Gaps = 16/89 (17%) Query: 185 HIVVMELIEGYPMRR----------LRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFN 234 H ++ I+G + R L+ + + + + GLIH D N Sbjct: 147 HYILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGN 206 Query: 235 IMIKDKLEDENDCGFVVIDFPQCISIQHQ 263 IM+ + D ++DF S + Sbjct: 207 IML------DADMQCHLVDFGSSSSDKEP 229 >2OC2-A nrPDB Length = 591 Score = 32.5 bits (72), Expect = 0.34, Method: Composition-based stats. Identities = 20/142 (14%), Positives = 45/142 (31%), Gaps = 15/142 (10%) Query: 213 LMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQHQDADYY-FQR 271 ++ + DL + L + E+N ++ D + ++ H + + Sbjct: 79 IIKKVQDLERAALPAQELEEYNKILLDMETTYS-----------VATVCHPNGSCLQLEP 127 Query: 272 DVDCIRRFFKKKLKYEPKPDSSMLDTEGFGDGYKYAYPDFKRDVKRTDNLDELVQASGFS 331 D+ + KYE + + G YP + + + L+ V A Sbjct: 128 DLTNV---MATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSW 184 Query: 332 KKHPGDRGLETAVESMRNAVYN 353 + LE +E + + Sbjct: 185 RSMYETPSLEQDLERLFQELQP 206 >5YV8-A nrPDB Length = 298 Score = 32.5 bits (72), Expect = 0.34, Method: Composition-based stats. Identities = 17/85 (20%), Positives = 30/85 (35%), Gaps = 11/85 (12%) Query: 187 VVMELIEGYPMRRL-----RKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKL 241 +V EL+ P+ + + DL+ I L +IH D N+++ + Sbjct: 115 MVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGE-- 172 Query: 242 EDENDCGFVVIDFPQCISIQHQDAD 266 D + DF + DA Sbjct: 173 ----DGHIKIADFGVSNEFKGSDAL 193 >4NIF-A nrPDB Length = 333 Score = 32.5 bits (72), Expect = 0.35, Method: Composition-based stats. Identities = 14/98 (14%), Positives = 40/98 (40%), Gaps = 9/98 (9%) Query: 174 FKVPEPFDNSRHIVVM-------ELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLI 226 + + +D+ +H+ ++ EL++ ++ + + + + L + G++ Sbjct: 65 ITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVV 124 Query: 227 HCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQHQD 264 H D NI+ D+ N + DF ++ ++ Sbjct: 125 HRDLKPSNILYVDE--SGNPECLRICDFGFAKQLRAEN 160 >5XZW-A nrPDB Length = 471 Score = 32.5 bits (72), Expect = 0.36, Method: Composition-based stats. Identities = 32/219 (14%), Positives = 71/219 (32%), Gaps = 36/219 (16%) Query: 49 TNRAISDLAKLSLISKMRNVKYDGYRLTYNGIDYLALKTMLNRD-----TVYSVGNTIGV 103 N + + + ++R+ + ++ G+ +M+ + +G Sbjct: 147 INDKFKQCLEQNKVDRIRSNLKNTSKIASPGLTSSTASSMVANKTGIFKDFSIIDEVVGQ 206 Query: 104 GKESDIYKV-SDKNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKE 162 G + + K G +KI S V N D + + + ++ R+ K Sbjct: 207 GAFATVKKAIERTTGKTFAVKI-----ISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKG 261 Query: 163 YQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRK------HKNIPKLYSDLMCF 216 + Y D + +VME + G + ++ ++ Sbjct: 262 F------YE---------DTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTA 306 Query: 217 IVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFP 255 I + + G+ H D NI+I E ++ + DF Sbjct: 307 IKYIHSMGISHRDLKPDNILI----EQDDPVLVKITDFG 341 >4PXI-A nrPDB Length = 215 Score = 32.5 bits (72), Expect = 0.37, Method: Composition-based stats. Identities = 23/138 (16%), Positives = 50/138 (36%), Gaps = 10/138 (7%) Query: 89 LNRDTVYSVGNTIGVGKESDIYK-VSDKNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQ 147 T+ + GV K + + + ++ +++I RTS ++ S + Sbjct: 27 YESTTLSEIVAHAGVTKGALYFHFAAKEDLAHAILEIQ--SRTSRRLAKDLDGRGYSSLE 84 Query: 148 GANWMH--LSRLAANKE-YQFMSMLYSKGFKV----PEPFDNSRHIVVMELIEGYPMRRL 200 + ++RL + L + G V P PF R I L++ + Sbjct: 85 ALMRLTFGMARLCVQGPVLRAGLRLATAGVPVRPPLPHPFTEWREIATSRLLDAVRQSDV 144 Query: 201 RKHKNIPKLYSDLMCFIV 218 + ++ + L+C +V Sbjct: 145 HQDIDVDSVAHTLVCSVV 162 >2GCD-A nrPDB Length = 309 Score = 32.5 bits (72), Expect = 0.37, Method: Composition-based stats. Identities = 28/136 (20%), Positives = 43/136 (31%), Gaps = 25/136 (18%) Query: 124 IHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAAN-------KEYQFMSMLYSKGFKV 176 + +G SF +V RD M S +N KE +F+ L Sbjct: 20 LREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRH----- 74 Query: 177 PEPFDNSR-----HI--VVMELIEGYPMRRLRKHKNI------PKLYSDLMCFIVDLANS 223 P H +VME G L HK + + + L + Sbjct: 75 PNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSH 134 Query: 224 GLIHCDFNEFNIMIKD 239 +IH D NI++ + Sbjct: 135 NMIHRDVKAGNILLSE 150 >4UY9-A nrPDB Length = 323 Score = 32.5 bits (72), Expect = 0.38, Method: Composition-based stats. Identities = 28/116 (24%), Positives = 47/116 (40%), Gaps = 16/116 (13%) Query: 150 NWMHLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKHKN-IPK 208 N ++L A ++ + L +G + EP +VME G P+ R+ K P Sbjct: 54 NVRQEAKLFAMLKHPNIIAL--RGVCLKEP----NLCLVMEFARGGPLNRVLSGKRIPPD 107 Query: 209 LYSDLMCFIVD----LANSGL---IHCDFNEFNIMIKDKLE--DENDCGFVVIDFP 255 + + I L + + IH D NI+I K+E D ++ + DF Sbjct: 108 ILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFG 163 >3DTC-A nrPDB Length = 271 Score = 32.5 bits (72), Expect = 0.38, Method: Composition-based stats. Identities = 28/116 (24%), Positives = 47/116 (40%), Gaps = 16/116 (13%) Query: 150 NWMHLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKHKN-IPK 208 N ++L A ++ + L +G + EP +VME G P+ R+ K P Sbjct: 52 NVRQEAKLFAMLKHPNIIAL--RGVCLKEP----NLCLVMEFARGGPLNRVLSGKRIPPD 105 Query: 209 LYSDLMCFIVD----LANSGL---IHCDFNEFNIMIKDKLE--DENDCGFVVIDFP 255 + + I L + + IH D NI+I K+E D ++ + DF Sbjct: 106 ILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFG 161 >6CMJ-A nrPDB Length = 321 Score = 32.5 bits (72), Expect = 0.40, Method: Composition-based stats. Identities = 17/85 (20%), Positives = 30/85 (35%), Gaps = 11/85 (12%) Query: 187 VVMELIEGYPMRRL-----RKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKL 241 +V EL+ P+ + + DL+ I L +IH D N+++ + Sbjct: 121 MVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGE-- 178 Query: 242 EDENDCGFVVIDFPQCISIQHQDAD 266 D + DF + DA Sbjct: 179 ----DGHIKIADFGVSNEFKGSDAL 199 >5TQX-A nrPDB Length = 655 Score = 32.5 bits (72), Expect = 0.41, Method: Composition-based stats. Identities = 26/94 (27%), Positives = 37/94 (39%), Gaps = 16/94 (17%) Query: 162 EYQFMSMLYSKGF----KVPEPFDNSRH---IVVMELIEGYPMRRLR---------KHKN 205 E Q M L VPE + H ++ ME G +R+L K Sbjct: 56 EIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ 115 Query: 206 IPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKD 239 I L SD+ I L + +IH D NI+++D Sbjct: 116 ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQD 149 >4U41-A nrPDB Length = 332 Score = 32.1 bits (71), Expect = 0.42, Method: Composition-based stats. Identities = 33/224 (14%), Positives = 68/224 (30%), Gaps = 39/224 (17%) Query: 94 VYSVGNTIGVGKESDIYKVSDKN-GNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWM 152 ++ + +G G +YK G +K+ + ++ + LKK + Sbjct: 25 IFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSH----- 79 Query: 153 HLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKHKNIPKLYSD 212 ++ ++ Y K P + + +VME + L K+ L D Sbjct: 80 ----------HRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKED 129 Query: 213 LMCFIVD--------LANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQHQD 264 + +I L +IH D N+++ + E ++DF Sbjct: 130 WIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAE------VKLVDFGVSAQ----- 178 Query: 265 ADYYFQRDVDCIRRFFKKKLKYEPKPDSSMLDTEGFGDGYKYAY 308 R V F P+ + + + D + Sbjct: 179 ----LDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLW 218 >4JXF-A nrPDB Length = 266 Score = 32.1 bits (71), Expect = 0.44, Method: Composition-based stats. Identities = 8/67 (11%), Positives = 23/67 (34%), Gaps = 6/67 (8%) Query: 202 KHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQ 261 ++ ++ L + G++H D N+++ + + DF ++ Sbjct: 106 SENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMN------IKIADFGLATQLK 159 Query: 262 HQDADYY 268 +Y Sbjct: 160 MPHEKHY 166 >4RGJ-A nrPDB Length = 520 Score = 32.1 bits (71), Expect = 0.47, Method: Composition-based stats. Identities = 12/66 (18%), Positives = 30/66 (45%), Gaps = 2/66 (3%) Query: 190 ELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGF 249 EL + R+ + ++ ++ I + + ++H D NI++ + +++ D Sbjct: 146 ELFDEIISRKRFYEIDAARIIKQILSGITYMHKNNVVHRDLKPENILL--ETKNKEDMII 203 Query: 250 VVIDFP 255 +IDF Sbjct: 204 KIIDFG 209 >3ZDU-A nrPDB Length = 325 Score = 32.1 bits (71), Expect = 0.53, Method: Composition-based stats. Identities = 30/155 (19%), Positives = 58/155 (37%), Gaps = 31/155 (20%) Query: 94 VYSVGNTIGVGKESDIYKVSDKN-GNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWM 152 +Y +G G + K KN G +KI + ++ Q N + Sbjct: 4 MYETLGKVGEGSYGTVMKCKHKNTGQIVAIKI----------------FYERPEQSVNKI 47 Query: 153 HLSRLAANKEYQ-----FMSMLYSKGFKVPEPFDNSRHIVVMEL---IEGYPMRRLRKHK 204 + + K++ + ++ + K+ F+ H V+ EL G +RLRK+ Sbjct: 48 AMREIKFLKQFHHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKY- 106 Query: 205 NIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKD 239 ++ I L ++ +IH D NI++ Sbjct: 107 -----LFQILRAIDYLHSNNIIHRDIKPENILVSQ 136 >5IG1-A nrPDB Length = 344 Score = 31.7 bits (70), Expect = 0.56, Method: Composition-based stats. Identities = 25/165 (15%), Positives = 61/165 (36%), Gaps = 17/165 (10%) Query: 99 NTIGVGKESDIYKVSDKN-GNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRL 157 + IG G S +++ +K G +K+ + S S N+ ++ ++ H + Sbjct: 23 SVIGKGAFSTVHRCVNKRTGEVCAVKV--IALKSLRSSEINKIK-REIGICSSLQHEHIV 79 Query: 158 AANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKHKNIPKLYSDLMCFI 217 + + ++ S Y F+ EL + R+ K+ ++ + Sbjct: 80 SMRRAFRDESHFYL-------VFEYVSGG---ELFDEIVTRKFYNEKDASACMHQILSAL 129 Query: 218 VDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQH 262 + +IH D N+++ K + + + DF + ++ Sbjct: 130 QHCHSKNIIHRDLKPENLLLASK---DPNAPVKITDFGLAVIMEQ 171 >3DAK-A nrPDB Length = 290 Score = 31.7 bits (70), Expect = 0.68, Method: Composition-based stats. Identities = 28/164 (17%), Positives = 53/164 (32%), Gaps = 17/164 (10%) Query: 95 YSVGNTIGVGKESDIYKVSDK-NGNPRVMKIHRLGR--TSFHSVRNNRDYLKKSNQGANW 151 Y + IG G + + +K L + TS + + + + Sbjct: 12 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIV 71 Query: 152 MHLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKHKNIPKLYS 211 + + E + L S G D +HIV +G + I + Sbjct: 72 SYYTSFVVKDELWLVMKLLSGG----SVLDIIKHIVA----KGEHKSGVLDESTIATILR 123 Query: 212 DLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFP 255 +++ + L +G IH D NI++ + D + DF Sbjct: 124 EVLEGLEYLHKNGQIHRDVKAGNILLGE------DGSVQIADFG 161 >3VHK-A nrPDB Length = 368 Score = 31.3 bits (69), Expect = 0.73, Method: Composition-based stats. Identities = 27/152 (17%), Positives = 46/152 (30%), Gaps = 26/152 (17%) Query: 191 LIEGYPMRRLRKHKNIPKLYSDLMCF-------------IVDLANSGLIHCDFNEFNIMI 237 +E + + + + LY D + + LA+ IH D NI++ Sbjct: 174 FVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILL 233 Query: 238 KDKLEDENDCGFVVIDFPQCISIQHQDADYYFQRDVD------CIRRFFKKKLKYEPKPD 291 +K + DF I ++D DY + D F + + Sbjct: 234 SEKNV------VKICDFGLARDI-YKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVW 286 Query: 292 SSMLDTEGFGDGYKYAYPDFKRDVKRTDNLDE 323 S + YP K D + L E Sbjct: 287 SFGVLLWEIFSLGASPYPGVKIDEEFCRRLKE 318 >1UA2-A nrPDB Length = 346 Score = 31.3 bits (69), Expect = 0.84, Method: Composition-based stats. Identities = 28/181 (15%), Positives = 60/181 (33%), Gaps = 27/181 (14%) Query: 90 NRDTVYSVGNTIGVGKESDIYKVSDKNGNP-RVMKIHRLGRTSFHSVRNNRDYLKKSNQG 148 +R Y + +G G+ + +YK DKN N +K +LG S ++ G Sbjct: 7 SRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRS------------EAKDG 54 Query: 149 ANWMHLSRLAANKEYQF-----MSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKH 203 N L + +E + + + FD + + + + + Sbjct: 55 INRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDN---SLVLTP 111 Query: 204 KNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQHQ 263 +I + + L ++H D N+++ + + + DF S Sbjct: 112 SHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDE------NGVLKLADFGLAKSFGSP 165 Query: 264 D 264 + Sbjct: 166 N 166 >2W1Z-A nrPDB Length = 368 Score = 31.3 bits (69), Expect = 0.87, Method: Composition-based stats. Identities = 12/51 (23%), Positives = 21/51 (41%), Gaps = 6/51 (11%) Query: 208 KLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCI 258 +L L+ L + GL+H DF NI++ + G + F + Sbjct: 195 QLTLQLIRLAASLQHYGLVHADFQVRNILLDQR------GGVFLTGFEHLV 239 >5U0A-N nrPDB Length = 254 Score = 30.9 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 13/42 (30%), Positives = 20/42 (47%), Gaps = 3/42 (7%) Query: 176 VPEPFDNSRHIV---VMELIEGYPMRRLRKHKNIPKLYSDLM 214 VP+P R V V EL+E P+ R ++ + DL+ Sbjct: 144 VPDPLLVLRRRVADPVRELVEAVPLPHRRVEEDAATVLVDLI 185 >4KIK-B nrPDB Length = 677 Score = 30.9 bits (68), Expect = 1.2, Method: Composition-based stats. Identities = 26/168 (15%), Positives = 56/168 (33%), Gaps = 9/168 (5%) Query: 96 SVGNTIGVGKESDIYKVSDKN-GNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHL 154 + +G G ++ + ++ G +K R S RN + + H Sbjct: 22 EMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQE----LSPRNRERWCLEIQIMRRLTHP 77 Query: 155 SRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKHKNIPKLYSDLM 214 + +AA + M L + + + + + + + + I L SD+ Sbjct: 78 NVVAARDVPEGMQNLAPNDLPL-LAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIA 136 Query: 215 CFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQH 262 + L + +IH D NI+++ E +ID + Sbjct: 137 SALRYLHENRIIHRDLKPENIVLQQ---GEQRLIHKIIDLGYAKELDQ 181 >3IS5-A nrPDB Length = 285 Score = 30.5 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 21/115 (18%), Positives = 35/115 (30%), Gaps = 25/115 (21%) Query: 181 DNSRHIVVMELIEGYPM----------RRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDF 230 D +VME EG + + + +L +M + + ++H D Sbjct: 91 DYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYFHSQHVVHKDL 150 Query: 231 NEFNIMIKDKLEDENDCGFVVIDFP------------QCISIQHQDADYYFQRDV 273 NI+ +D +IDF A F+RDV Sbjct: 151 KPENILFQDTSPH---SPIKIIDFGLAELFKSDEHSTNAAGTALYMAPEVFKRDV 202 >4IVN-A nrPDB Length = 278 Score = 30.5 bits (67), Expect = 1.3, Method: Composition-based stats. Identities = 25/113 (22%), Positives = 41/113 (36%), Gaps = 10/113 (8%) Query: 67 NVKYDGYRLTYNGIDYLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPRVMKIHR 126 D + T ID +L ++ R IGVG S + G ++ R Sbjct: 99 QSAVDSLQDTAKLIDRKSLARIVERVHQAEFIGCIGVGASSIV-------GRYLAYRLIR 151 Query: 127 LGRTS--FHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMSML-YSKGFKV 176 +G+ + F +S+QG W +S + KE + L Y + V Sbjct: 152 IGKKAIMFEDTHLAAMSASRSSQGDLWFAVSSSGSTKEVIHAAGLAYKRDIPV 204 >4EPA-A nrPDB Length = 655 Score = 30.5 bits (67), Expect = 1.3, Method: Composition-based stats. Identities = 12/27 (44%), Positives = 17/27 (62%), Gaps = 2/27 (7%) Query: 10 YLTTDDFRVLQAVEQGSR--SHEVVPT 34 Y+ TDD+RV V QG + + +VPT Sbjct: 421 YMLTDDWRVYTRVAQGYKPSGYNIVPT 447 >1V0B-A nrPDB Length = 288 Score = 30.2 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 26/150 (17%), Positives = 49/150 (32%), Gaps = 29/150 (19%) Query: 101 IGVGKESDIYKVSDKNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAAN 160 IG G +YK + G +K RL K ++G + ++ Sbjct: 10 IGEGTYGVVYKAQNNYGETFALKKIRLE---------------KEDEGIPSTTIREISIL 54 Query: 161 KEYQ--FMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKHK------NIPKLYSD 212 KE + + LY R ++V E ++ + L + Sbjct: 55 KELKHSNIVKLYDV------IHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQ 108 Query: 213 LMCFIVDLANSGLIHCDFNEFNIMIKDKLE 242 L+ I + ++H D N++I + E Sbjct: 109 LLNGIAYCHDRRVLHRDLKPQNLLINREGE 138 >3H4J-B nrPDB Length = 336 Score = 30.2 bits (66), Expect = 2.1, Method: Composition-based stats. Identities = 16/110 (14%), Positives = 41/110 (37%), Gaps = 10/110 (9%) Query: 140 DYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGF-KVPEPFDNSRHIVVM------ELI 192 ++ + + MH+ +E ++ +L K+ + IV++ EL Sbjct: 40 KFISRQLLKKSDMHMRV---EREISYLKLLRHPHIIKLYDVITTPTDIVMVIEYAGGELF 96 Query: 193 EGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLE 242 + ++ + + ++C I ++H D N+++ D L Sbjct: 97 DYIVEKKRMTEDEGRRFFQQIICAIEYCHRHKIVHRDLKPENLLLDDNLN 146 >2RIO-A nrPDB Length = 434 Score = 29.8 bits (65), Expect = 2.5, Method: Composition-based stats. Identities = 14/70 (20%), Positives = 27/70 (38%), Gaps = 7/70 (10%) Query: 199 RLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIK-------DKLEDENDCGFVV 251 +L+K N L + + L + +IH D NI++ D+ + ++ Sbjct: 110 KLQKEYNPISLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILI 169 Query: 252 IDFPQCISIQ 261 DF C + Sbjct: 170 SDFGLCKKLD 179 >3Q5I-A nrPDB Length = 504 Score = 29.8 bits (65), Expect = 2.5, Method: Composition-based stats. Identities = 26/162 (16%), Positives = 60/162 (37%), Gaps = 18/162 (11%) Query: 101 IGVGKESDIYKVSDKNG-NPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAA 159 +G G ++ +KNG + + +K+ + ++ F R + D + L Sbjct: 44 LGSGAYGEVLLCKEKNGHSEKAIKV--IKKSQFDKGRYSDDNKNIEKFHEEIYNEISLLK 101 Query: 160 NKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPM------RRLRKHKNIPKLYSDL 213 + ++ + L+ + + +V E EG + R + + + Sbjct: 102 SLDHPNIIKLFD--VFEDKKYFY----LVTEFYEGGELFEQIINRHKFDECDAANIMKQI 155 Query: 214 MCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFP 255 + I L ++H D NI++++K N ++DF Sbjct: 156 LSGICYLHKHNIVHRDIKPENILLENKNSLLN---IKIVDFG 194 >6QAU-A nrPDB Length = 280 Score = 29.8 bits (65), Expect = 2.5, Method: Composition-based stats. Identities = 14/78 (17%), Positives = 25/78 (32%), Gaps = 9/78 (11%) Query: 187 VVMELIEG------YPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIK-- 238 +VME G + I + + L + G+IH D NI++ Sbjct: 87 LVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYA 146 Query: 239 -DKLEDENDCGFVVIDFP 255 + + + DF Sbjct: 147 NRRKSSVSGIRIKIADFG 164 >6HMD-A nrPDB Length = 365 Score = 29.8 bits (65), Expect = 2.5, Method: Composition-based stats. Identities = 20/99 (20%), Positives = 37/99 (37%), Gaps = 13/99 (13%) Query: 186 IVVMELIEG---YPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLE 242 +V E I + ++ +I +L+ + + G++H D N+MI Sbjct: 126 ALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMI----- 180 Query: 243 DENDCGFVVIDFPQCISIQHQDADYYFQRDVDCIRRFFK 281 D +ID+ H +Y +V R+FK Sbjct: 181 DHQQKKLRLIDWG-LAEFYHPAQEY----NVRVASRYFK 214 >2BRG-A nrPDB Length = 297 Score = 29.4 bits (64), Expect = 2.8, Method: Composition-based stats. Identities = 12/84 (14%), Positives = 30/84 (35%), Gaps = 6/84 (7%) Query: 190 ELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGF 249 EL + + + + LM +V L G+ H D N+++ ++ + Sbjct: 91 ELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLK----- 145 Query: 250 VVIDFPQCISIQHQDADYYFQRDV 273 + DF ++ + + + Sbjct: 146 -ISDFGLATVFRYNNRERLLNKMC 168 >1U59-A nrPDB Length = 287 Score = 29.4 bits (64), Expect = 2.9, Method: Composition-based stats. Identities = 11/61 (18%), Positives = 25/61 (40%), Gaps = 7/61 (11%) Query: 187 VVMELIEGYPMRRLRK-------HKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKD 239 +VME+ G P+ + N+ +L + + L +H D N+++ + Sbjct: 86 LVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN 145 Query: 240 K 240 + Sbjct: 146 R 146 >6CCF-A nrPDB Length = 290 Score = 29.4 bits (64), Expect = 3.1, Method: Composition-based stats. Identities = 16/77 (20%), Positives = 27/77 (35%), Gaps = 10/77 (12%) Query: 179 PFDNSRHIVVMELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIK 238 FD R VME+ P + D++ + L ++H D N+++ Sbjct: 108 VFDLLRKGPVMEVPCDKPF----SEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLG 163 Query: 239 DKLEDENDCGFVVIDFP 255 D D + DF Sbjct: 164 D------DGHVKIADFG 174 >1KOB-A nrPDB Length = 387 Score = 29.4 bits (64), Expect = 3.3, Method: Composition-based stats. Identities = 11/83 (13%), Positives = 31/83 (37%), Gaps = 11/83 (13%) Query: 186 IVVMELIEGYPMRRLRKHKNIPKLYSDLMCFIVD-------LANSGLIHCDFNEFNIMIK 238 ++++E + G + ++ ++++ ++ + ++H D NIM + Sbjct: 124 VLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHEHSIVHLDIKPENIMCE 183 Query: 239 DKLEDENDCGFVVIDFPQCISIQ 261 K +IDF + Sbjct: 184 TKKA----SSVKIIDFGLATKLN 202 >3J6B-S nrPDB Length = 258 Score = 29.4 bits (64), Expect = 3.4, Method: Composition-based stats. Identities = 25/142 (17%), Positives = 55/142 (38%), Gaps = 11/142 (7%) Query: 4 DTSHMRYLTTDDFRVLQAVEQGSRSHEVVPTPLIHQISGMRSQSGTNRAISDLAKL-SLI 62 + S + T + + V++G S +++ ++ + + IS + + + Sbjct: 84 NISESKAKTRKKW-LPNVVKKGLWS------ETLNRKISIKMTAKVLKTISKEGGIDNYL 136 Query: 63 SKMRNVKYDGYRLTYNGIDYLALKT---MLNRDTVYSVGNTIGVGKESDIYKVSDKNGNP 119 +K ++ + T + Y LK + N + + GK++ IY NG+P Sbjct: 137 TKEKSARIKELGPTGWKLRYRVLKRKDEIENPPHKDAPIIEMAGGKKAKIYYDEIVNGSP 196 Query: 120 RVMKIHRLGRTSFHSVRNNRDY 141 R + + R SF +Y Sbjct: 197 RKISVGRRRLMSFLYPLEKLEY 218 >5M07-A nrPDB Length = 276 Score = 29.4 bits (64), Expect = 3.5, Method: Composition-based stats. Identities = 26/156 (16%), Positives = 52/156 (33%), Gaps = 24/156 (15%) Query: 141 YLKKSNQGANWMHLSRL----AANKEYQF-MSMLYSKGFKVPEPFDNSRHI--------- 186 YL + W L L AA+ E++ ++ P H Sbjct: 47 YLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPHILEVHDRGEFDGQLW 106 Query: 187 VVMELIEGYPMRRLRKHKNIPKL-YSDLMCFIVDLA-------NSGLIHCDFNEFNIMIK 238 + M+ ++G + + L +++ + +A GL+H D N N+++ Sbjct: 107 IAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYAHQRGLLHRDVNPANVVLT 166 Query: 239 DKLEDENDCGFVVIDFPQCISIQHQDADYYFQRDVD 274 + D ++ DF + + DVD Sbjct: 167 SQ--SAGDQRILLADFGIASQPSYPAPELSAGADVD 200 >5WLC-LS nrPDB Length = 594 Score = 29.0 bits (63), Expect = 3.7, Method: Composition-based stats. Identities = 16/54 (29%), Positives = 31/54 (57%), Gaps = 6/54 (11%) Query: 354 SDDDMSNDEAEEENGEGDYSEEDEYYDSELDNESS------EDDSEDAQEEENE 401 ++ +M ++ E+E E D SEEDE + ELD+ ++ +D + +++NE Sbjct: 47 NEQEMDVEDQEDEGSESDNSEEDEAQNGELDHVNNDQLFFVDDGGNEDSQDKNE 100 >6I9E-A nrPDB Length = 409 Score = 29.0 bits (63), Expect = 4.4, Method: Composition-based stats. Identities = 13/70 (18%), Positives = 28/70 (40%), Gaps = 4/70 (5%) Query: 106 ESDIYKVSDKNGNPRVMKI-HRLGRTSFHSVRNNRDYLKKSNQGANWMHL--SRLAANKE 162 E ++Y + ++ M H++G TS V + + + + SR+ KE Sbjct: 62 ELELYLLRTQDAEQTGMTFVHQVGSTS-LPVEARVAKVDLAKATWSPLAFKESRVWDEKE 120 Query: 163 YQFMSMLYSK 172 ++ L + Sbjct: 121 ILYLGRLADE 130 >5JZN-A nrPDB Length = 280 Score = 28.6 bits (62), Expect = 5.4, Method: Composition-based stats. Identities = 27/176 (15%), Positives = 59/176 (33%), Gaps = 29/176 (16%) Query: 95 YSVGNTIGVGKESDIYKVSDKN-GNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMH 153 Y VG TIG G + + + +++ +KI ++ ++ K+ Sbjct: 21 YKVGRTIGDGNFAVVKECVERSTAREYALKI----------IKKSKCRGKEHMIQNEVSI 70 Query: 154 LSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELI------EGYPMRRLRKHKNIP 207 L R+ +L + VP +VMEL+ + ++ Sbjct: 71 LRRVKHPN-----IVLLIEEMDVPTEL-----YLVMELVKGGDLFDAITSTNKYTERDAS 120 Query: 208 KLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQHQ 263 + +L I L + ++H D N+++ + + + DF + Sbjct: 121 GMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSK--SLKLGDFGLATIVDGP 174 >4NEU-A nrPDB Length = 333 Score = 28.2 bits (61), Expect = 6.2, Method: Composition-based stats. Identities = 15/82 (18%), Positives = 34/82 (41%), Gaps = 12/82 (14%) Query: 180 FDNSRHIVVMELIEGYPMRRLRKHKNIP------KLYSDLMCFIVDLANSGLIHCDFNEF 233 + ++ +VME +E + + K + ++ +++ + L G+IH D Sbjct: 92 IEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPE 151 Query: 234 NIMIKDKLEDENDCGFVVIDFP 255 NI++ +ND + D Sbjct: 152 NILV------DNDFHIKIADLG 167 >5EW5-A nrPDB Length = 582 Score = 28.2 bits (61), Expect = 6.6, Method: Composition-based stats. Identities = 18/89 (20%), Positives = 41/89 (46%), Gaps = 3/89 (3%) Query: 318 TDNLDELVQASGFSKK-HPGDRGLETAVESMRNAVYNSDDDMSNDEAEEENGEGDYSEED 376 T+N D+ V+ +GF++ + D + +S NAVY S D+ + + ++ + + + Sbjct: 250 TNNTDKDVRPAGFTQGGNTRDAVIRFPKDSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQ 309 Query: 377 EYYDSELDNESSEDDSEDAQE--EENERI 403 E+ + + + E + NE + Sbjct: 310 EWDATHPVEAAERNCERARAELNQANEDV 338 >4GVP-A nrPDB Length = 208 Score = 27.8 bits (60), Expect = 9.8, Method: Composition-based stats. Identities = 18/79 (22%), Positives = 35/79 (44%), Gaps = 7/79 (8%) Query: 27 RSHEVVPTP-----LIHQISGMRSQSGTNRAISDLAKLSLISKMRNVKYDGYRLTYNGID 81 ++HE+ P L+ + G+ + + + + + L L S + + + YR G+D Sbjct: 42 KAHELKPDLILMDLLMEDMDGVEATTQIKKDLPQIKVLMLTSFIEDKEV--YRALDAGVD 99 Query: 82 YLALKTMLNRDTVYSVGNT 100 LKT +D +V T Sbjct: 100 SYILKTTSAKDIADAVRKT 118 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.307 0.123 0.300 Lambda K H 0.267 0.0376 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 14,607,792 Number of Sequences: 36641 Number of extensions: 579080 Number of successful extensions: 3340 Number of sequences better than 10.0: 164 Number of HSP's better than 10.0 without gapping: 117 Number of HSP's successfully gapped in prelim test: 147 Number of HSP's that attempted gapping in prelim test: 2468 Number of HSP's gapped (non-prelim): 627 length of query: 425 length of database: 10,336,785 effective HSP length: 100 effective length of query: 325 effective length of database: 6,672,685 effective search space: 2168622625 effective search space used: 2168622625 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 60 (27.8 bits)